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Job DescriptionP04983
Confidence100.00%DateThu Jan 5 10:58:31 GMT 2012
Rank2Aligned Residues446
% Identity33%Templatec3g5uB_
PDB info PDB header:membrane proteinChain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding
Resolution3.80 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   5....10.... .....20.........30.........40.........50.........60.........70.........80.
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Query Sequence  LQLKGIDKAF. . . PGVKALSGAALNVYPGRVMALVGENGAGKSTMMKVLTGIYTRDAGTLLWLGKETTFTGPKSSQEAGI
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Template Sequence  LEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREI. I
Template Known Secondary structure 

SSTTS

S
TT


SSTTTTTSS

STTGGGS
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   388.390.........400.........410.........420.........430.........440.........450.........460..... .
 
   82.......90.........100.........110.........120.........130.........140. ........150
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Query Sequence  GIIHQELNLIPQLTIAENIFLGREFVNRFGKIDWKTMYAEADKLLAKLNLRFKSDKLVGD. . . . . . . . . . . LSIGDQQMV
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Template Sequence  GVVSQEPVLFAT. TIAENIRYGREDVT. . . . . . . . . . MDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRI
Template Known Secondary structure  SS



SS.

SS

..........TT
TTSTTGGG


SSSS
SS
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   467..470........ .480.........490.. .......500.........510.........520.........530.....
 
   151........160.........170.........180.........190.........200.........210.........220.........230
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Query Sequence  EIAKVLSFESKVIIMDEPTDALTDTETESLFRVIRELKSQGRGIVYISHRMKEIFEICDDVTVFRDGQFIAEREVASLTE
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Template Sequence  AIARALVRNPKILLLDEATSALDTESEAVVQAALDKARE. GRTTIVIAHRLSTVR. NADVIAGFDGGVIVEQGNHDELMR
Template Known Secondary structure 

SBTT
SS
TT.SS
S
T.T
S
SSS




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   536...540.........550.........560.........570.... .....580......... 590.........600.........610...
 
   231........240.........250....
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Query Sequence  DSLIEMMVGRKLEDQYPHLDKAPG. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Conservation                                               
                                  
Template Sequence  EKGIYFKLVMTQTLDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSNL
Template Known Secondary structure  TST









TTT



SS
STT
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   614.....620.........630.........640.........650.........660.........670.........680.........690...
 
  
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation               
                   
   
   
               
 
  
   
           
 
Template Sequence  FSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLA
Template Known Secondary structure 

S
S

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   751........760.........770.........780.........790.........800.........810.........820.........830
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation    
          
        
 

 
    
                               
 
 
   

      
Template Sequence  VIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQ
Template Known Secondary structure  SS
STTTT
TTTTT
SS
Template Predicted Secondary structure 
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   831........840.........850.........860.........870.........880.........890.........900.........910
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                                               
  
                           
   
Template Sequence  KFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAAAFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSF
Template Known Secondary structure 

TTTT
S
STTTSS
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   911........920.........930.........940.........950.........960.........970.........980.........990
 
   255....260.. .......270.........280.........
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . DIRLKVDN. LCGPGVNDVSFTLRKGEILGVSGLMGA
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Template Sequence  APDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGC
Template Known Secondary structure  SS
SS




SS
S




TTT





S
GGG

SS


SSS
SSST
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   991........1000.........1010.........1020.........1030.........1040.........1050.........1060.........1070
 
   290.........300.........310.........320.........330.........340.........350.........360.........
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Query Sequence  GRTELMKVLYGALPRTSGYVTLDGHEVVTRSPQDGLANGIVYISEDRKRDGLVLGMSVKENMSLTALRYFSRAGGSLKHA
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Template Sequence  GKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQW. LRAQLGIVSQEP. . . . ILFDCSIAENIA. . . . . . YGDNSRVVSYE
Template Known Secondary structure  TTTSS

SSSSS
BTSS
.TTS
SS
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SSBT......


SS



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   1071........1080.........1090.........1100.... .....1110...... ...1120........ .1130.........
 
   370.........380.........390.... .....400.........410.........420.........430........
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Query Sequence  DEQQAVSDFIRLFNVKTPSMEQAIG. . . . . . . . . . . LLSGGNQQKVAIARGLMTRPKVLILDEPTRGVDVGAKKEIYQLI
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Template Sequence  E. . . . IVRAAKEANI. HQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEAL
Template Known Secondary structure  ....T
.SSTTTGGG
B
STTS
SS


SSS
SSS

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   1140 .........1150 .........1160.........1170.........1180.........1190.........1200.........1210....
 
   439440.........450.........460.........470.........480..
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Query Sequence  NQFKADGLSIILVSSEMPEVLGMSDRIIVMHEGHLSGEFTREQA
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Template Sequence  DKAR. EGRTCIVIAHRLSTIQN. ADLIVVIQNGKVKEHGTHQQL
Template Known Secondary structure  S.SSS

S
TTGGGS.
STB
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   1215... .1220.........1230..... ....1240.........1250......
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
© Structural Bioinformatics Group, Imperial College, London
Lawrence Kelley, Benjamin Jefferys 
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