Secondary structure and disorder prediction

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Sequence		M	C	R	H	S	L	R	S	D	G	A	G	F	Y	Q	L	A	G	C	E	Y	S	F	S	A	I	K	I	A	A	G	G	Q	F	L	P	V	I	C	A	M	A	M	K	S	H	F	F	L	I	S	V	L	N	R	R	L	T	L	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?			?																		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.
Sequence		A	V	Q	G	I	L	G	R	F	S	L	F
Secondary structure
SS confidence
Disorder					?		?	?		?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1bts chain A Region: 52 - 67 Aligned: 16 Modelled: 16 Confidence: 32.3% Identity: 50% PDB header:transmembrane protein Chain: A: PDB Molecule:band 3 anion transport protein; PDBTitle: the solution structures of the first and second2 transmembrane-spanning segments of band 3 Phyre2 PDB 1btt chain A Region: 52 - 67 Aligned: 16 Modelled: 16 Confidence: 32.3% Identity: 50% PDB header:transmembrane protein Chain: A: PDB Molecule:band 3 anion transport protein; PDBTitle: the solution structures of the first and second2 transmembrane-spanning segments of band 3 Phyre2 PDB 3etb chain J Region: 5 - 13 Aligned: 9 Modelled: 9 Confidence: 25.5% Identity: 67% PDB header:immune system/toxin Chain: J: PDB Molecule:anthrax protective antigen; PDBTitle: crystal structure of the engineered neutralizing antibody2 m18 complexed with anthrax protective antigen domain 4 Phyre2 PDB 2zme chain D Region: 42 - 66 Aligned: 25 Modelled: 25 Confidence: 9.7% Identity: 32% PDB header:protein transport Chain: D: PDB Molecule:vacuolar protein-sorting-associated protein 25; PDBTitle: integrated structural and functional model of the human escrt-ii2 complex Phyre2 PDB 3qte chain A Region: 62 - 69 Aligned: 8 Modelled: 8 Confidence: 7.8% Identity: 63% PDB header:antimicrobial protein Chain: A: PDB Molecule:defensin-6; PDBTitle: crystal structure of human alpha-defensin 6 (h27w mutant) Phyre2 PDB 3cuq chain D Region: 42 - 66 Aligned: 25 Modelled: 25 Confidence: 7.0% Identity: 32% PDB header:protein transport Chain: D: PDB Molecule:vacuolar protein-sorting-associated protein 25; PDBTitle: integrated structural and functional model of the human escrt-ii2 complex Phyre2 PDB 2fhd chain A Region: 15 - 27 Aligned: 13 Modelled: 13 Confidence: 6.4% Identity: 38% PDB header:cell cycle Chain: A: PDB Molecule:dna repair protein rhp9/crb2; PDBTitle: crystal structure of crb2 tandem tudor domains Phyre2 PDB 1xb4 chain A domain 1 Region: 53 - 66 Aligned: 14 Modelled: 14 Confidence: 6.2% Identity: 14% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Vacuolar sorting protein domain Phyre2 PDB 2a06 chain V Region: 1 - 12 Aligned: 12 Modelled: 12 Confidence: 6.0% Identity: 58% PDB header:oxidoreductase Chain: V: PDB Molecule:ubiquinol-cytochrome c reductase iron-sulfur subunit, PDBTitle: bovine cytochrome bc1 complex with stigmatellin bound Phyre2 PDB 1rpu chain A Region: 18 - 45 Aligned: 28 Modelled: 28 Confidence: 5.7% Identity: 43% Fold: Tombusvirus P19 core protein, VP19 Superfamily: Tombusvirus P19 core protein, VP19 Family: Tombusvirus P19 core protein, VP19 Phyre2 PDB 1rpu chain A Region: 18 - 45 Aligned: 28 Modelled: 28 Confidence: 5.7% Identity: 43% PDB header:rna binding protein/rna Chain: A: PDB Molecule:19 kda protein; PDBTitle: crystal structure of cirv p19 bound to sirna Phyre2 PDB 1ppj chain I Region: 1 - 12 Aligned: 12 Modelled: 12 Confidence: 5.5% Identity: 58% Fold: Non-globular alpha+beta subunits of globular proteins Superfamily: Non-globular alpha+beta subunits of globular proteins Family: Ubiquinol-cytochrome c reductase 8 kDa protein Phyre2 PDB 1zej chain A Region: 7 - 21 Aligned: 15 Modelled: 15 Confidence: 5.4% Identity: 27% PDB header:oxidoreductase Chain: A: PDB Molecule:3-hydroxyacyl-coa dehydrogenase; PDBTitle: crystal structure of the 3-hydroxyacyl-coa dehydrogenase (hbd-9,2 af2017) from archaeoglobus fulgidus dsm 4304 at 2.00 a resolution Phyre2 1 c1btsA_ 2 c1bttA_ 3 c3etbJ_ 4 c2zmeD_ 5 c3qteA_ 6 c3cuqD_ 7 c2fhdA_ 8 d1xb4a1 9 c2a06V_ 10 d1rpua_ 11 c1rpuA_ 12 d1ppji_ 13 c1zejA_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1btsA_ 32.3 50 PDB header:transmembrane protein Chain: A: PDB Molecule:band 3 anion transport protein; PDBTitle: the solution structures of the first and second2 transmembrane-spanning segments of band 3 2 c1bttA_ 32.3 50 PDB header:transmembrane protein Chain: A: PDB Molecule:band 3 anion transport protein; PDBTitle: the solution structures of the first and second2 transmembrane-spanning segments of band 3 3 c3etbJ_ 25.5 67 PDB header:immune system/toxin Chain: J: PDB Molecule:anthrax protective antigen; PDBTitle: crystal structure of the engineered neutralizing antibody2 m18 complexed with anthrax protective antigen domain 4 4 c2zmeD_ 9.7 32 PDB header:protein transport Chain: D: PDB Molecule:vacuolar protein-sorting-associated protein 25; PDBTitle: integrated structural and functional model of the human escrt-ii2 complex 5 c3qteA_ 7.8 63 PDB header:antimicrobial protein Chain: A: PDB Molecule:defensin-6; PDBTitle: crystal structure of human alpha-defensin 6 (h27w mutant) 6 c3cuqD_ 7.0 32 PDB header:protein transport Chain: D: PDB Molecule:vacuolar protein-sorting-associated protein 25; PDBTitle: integrated structural and functional model of the human escrt-ii2 complex 7 c2fhdA_ 6.4 38 PDB header:cell cycle Chain: A: PDB Molecule:dna repair protein rhp9/crb2; PDBTitle: crystal structure of crb2 tandem tudor domains 8 d1xb4a1 6.2 14 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Vacuolar sorting protein domain 9 c2a06V_ 6.0 58 PDB header:oxidoreductase Chain: V: PDB Molecule:ubiquinol-cytochrome c reductase iron-sulfur subunit, PDBTitle: bovine cytochrome bc1 complex with stigmatellin bound 10 d1rpua_ 5.7 43 Fold:Tombusvirus P19 core protein, VP19 Superfamily:Tombusvirus P19 core protein, VP19 Family:Tombusvirus P19 core protein, VP19 11 c1rpuA_ 5.7 43 PDB header:rna binding protein/rna Chain: A: PDB Molecule:19 kda protein; PDBTitle: crystal structure of cirv p19 bound to sirna 12 d1ppji_ 5.5 58 Fold:Non-globular alpha+beta subunits of globular proteins Superfamily:Non-globular alpha+beta subunits of globular proteins Family:Ubiquinol-cytochrome c reductase 8 kDa protein 13 c1zejA_ 5.4 27 PDB header:oxidoreductase Chain: A: PDB Molecule:3-hydroxyacyl-coa dehydrogenase; PDBTitle: crystal structure of the 3-hydroxyacyl-coa dehydrogenase (hbd-9,2 af2017) from archaeoglobus fulgidus dsm 4304 at 2.00 a resolution

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0