|   |
12 | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | |
. | |
|
|
|
|
. | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60 | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . |
Predicted Secondary structure |   |
|
|
|
|  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |
|
| . |
| . | . | . | . | . |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
| . |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
R | P | D | D | W | H | L | H | L | R | D | G | D | M | L | K | T | V | V | P | Y | T | S | E | I | Y | G | R | A | I | V | M | P | . |
N | . |
. |
. |
. |
. |
L | A | P | P | V | T | T | V | E | A | A | V | A | Y | R | Q | R | I | L | D | A | V | P | A | G | H | D | F | T | P | L | M | T | C | Y | L | T | D | S | L |
Query Conservation |   |
|   |
|
|   |
|
|
|   |
|
|
|
|   |   |
|
|
|   |
|
|
|
|
|
|
|
|
|
|   |   |
|
| . |
| . | . | . | . | . |
|   |
|
|
|   |
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
| . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . |
|
|
Template Conservation |   |
|   |
|
|   |
|
|
|   |   |   |
| . | . | . |   |   |   |   |   |
|
|
|
|
|
|
|
|
|   |   |
|   |   |
|   |
|
|
|   |   |   |   |   |
|
|   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |
|   |
|   |
|   |   |   |
|   |   | . | . | . | . | . |   |   |
Template Sequence |   |
G | G | I | D | T | H | V | H | F | I | N | P | . |
. |
. |
D | Q | V | D | V | A | L | A | N | G | I | T | T | L | F | G | G | G | T | G | P | A | E | G | S | K | A | T | T | V | T | P | G | P | W | N | I | E | K | M | L | K | S | T | E | G | L | P | I | N | V | G | I | L | G | K | G | H | . |
. |
. |
. |
. |
G | S |
Template Known Secondary structure |   |
|  |  |  |  |  |  |  |
|
|
| T | . | . | . | T |  |  |  |  |  |  |  | T | T |  |  |  |  |  |  |  |
|
| S | S |
|  |  |  |  |  | S | S |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  | T | T |
| S | S |  |  |  |  | B |
|
|
|
| . | . | . | . | . |
| S |
Template Predicted Secondary structure |   |
|
|  |  |  |  |  |
|
|
|
|  | . | . | . |  |  |  |  |  |  |  |  |
|
|
|
|  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |
|
|
|
|  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|
| . | . | . | . | . |
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
132 | . | . | . | . | . | . | . | 140 | . | . | . | |
|
|
. | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | |
|
|
|
|
. | . |
  |
  |   |
86 | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120 | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . |
Predicted Secondary structure |   |
|  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
D | P | N | E | L | E | R | G | F | N | E | G | V | F | T | A | A | K | L | Y | P | A | N | A | T | T | N | S | S | H | G | V | T | S | I | D | A | I | M | P | V | L | E | R | M | E | K | I | G | M | P | L | L | V | H | G | E | V | T | H | A | D | I | D | I | F | D | R | E | A | R | F | I | E | S | V | M | E | P | L |
Query Conservation |   |
  |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|   |   |   |   |   |   |   |
|   |   |
|
|   |
|   |   |   |
|   |   |   |
|   |   |   |   |   |   |
|   |   |
|   |
|
|
|
|
|   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
Template Conservation |   |
  |   |   |   |
|   |   |   |   |
|   |
|   |   |   |   |   |   |
|   |   | . | . | . | . | . | . | . | . | . | . |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |
|   |
|
|
|
|   |   |   |
|   |   |   |   | . | . | . | . | . | . | . | . | . |   |   |   |
|   |   |
Template Sequence |   |
S | I | A | P | I | M | E | Q | I | D | A | G | A | A | G | L | I | H | E | D | W | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
G | A | T | P | A | S | I | D | R | S | L | T | V | A | D | E | A | D | V | Q | V | A | I | H | S | D | T | L | N | E | A | G | F | L | . |
. |
. |
. |
. |
. |
. |
. |
. |
E | D | T | L | R | A |
Template Known Secondary structure |   |
S |  |  |  |  |  |  |  |  |  |  | T |
|
| B |
|
| B | G | G | G | . | . | . | . | . | . | . | . | . | . |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  | T |
| B |
|  |  | B |
|
| T | T |
| S | S |
|
|  | . | . | . | . | . | . | . | . | . |  |  |  |  |  |  |
Template Predicted Secondary structure |   |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | . | . | . | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  | . | . | . | . | . | . | . | . | . |  |  |  |  |  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
204 | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | |
|
|
|
|
|
|
|
|
|
. | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | |
|
|
|
|
|
|
|
|
. | 260 | . | . | . | . |
  |
  |   |
166 | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
. | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . |
Predicted Secondary structure |   |
 |  |  |
|
|
|
|
|  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |
|  |  |  |  |
|
|
|
|
|
|
|
|  |  |  |  |
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
R | Q | R | L | T | A | L | K | V | V | F | E | H | I | T | T | K | D | A | A | D | Y | V | R | D | G | N | E | R | L | A | A | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
T | I | T | P | Q | H | L | M | F | N | R | N | H | M | L | V | G | G | V | R | P | H | L | Y | C | L | P |
Query Conservation |   |
  |   |   |   |   |   |   |   |
|   |
|   |
|
|
|
|   |   |
|
|
|   |
|
|   |   |
|   |   |
|
|   | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|   |
|   |   |   |
|   |   |   |   |   |   |   |   |   |   |
|   |   |
|
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . |
|
|
|
|
|
|
Template Conservation |   |
  |   |   |   |   |   |   |   |   |
|   |
|   |   |   |   |   |   |   |   |
|   |
|   |   |
|   |   |   |   |
|   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|   |   |   |   |   |   |   | . | . | . | . | . | . | . |   |   |   |   |   |   |
Template Sequence |   |
I | N | G | R | V | I | H | S | F | H | V | E | G | A | G | G | G | H | A | P | D | I | M | A | M | A | G | H | P | N | V | L | P | S | S | T | N | P | T | R | P | F | T | V | N | T | I | D | E | H | L | D | M | L | M | V | C | H | H | L | K | Q | N | I | P | E | D | . |
. |
. |
. |
. |
. |
. |
V | A | F | A | D | S |
Template Known Secondary structure |   |
 | T | T |
|
|  |  |  | T | T | T | T | S | T | T | S | S | S | T | T | T | G | G | G | G | G | G | S | T | T |  |  |  | B |
|
| S | T | T | S | S |
| B | T | T |  |  |  |  |  |  |  |  |  |  |  |  |  | T |
|
| T | T | S |  |  |  | . | . | . | . | . | . | . |  |  |  |  |  |  |
Template Predicted Secondary structure |   |
 |
|
|
|
|
|
|
|  |  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |
|
|
|
|
|
|
| . | . | . | . | . | . | . |
|
|
|
|
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
266 | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | |
|
|
|
|
|
|
. | . | . | . | . | . |
  |
  |   |
225 | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | |
|
. | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . |
Predicted Secondary structure |   |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  | . | . |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|  |  |  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
I | L | K | R | N | I | H | Q | Q | A | L | R | E | L | V | A | S | G | F | N | R | V | F | L | G | T | D | S | A | P | H | A | R | H | R | K | E | S | S | C | G | C | A | G | C | F | N | A | P | T | A | L | G | S | Y | A | T | . |
. |
V | F | E | E | M | N | A | L | Q | H | F | E | A | F | C | S | V | N | G | P | Q |
Query Conservation |   |
|
|
|   |   |   |
|
|   |
|
|   |   |   |
|   |   |
|   |
|
|   |   |
|
|
|
|
|
|
|
|   |   |
|
|
|   |   |   |   |   |   |   |
|
|   |
|   |
|   |   |
|
|
|
|   |   | . | . |   |   |   |   |   |   |   |
|   |   |   |
|   |   |   |
|   |
|
|
|
|
Alig confidence |   |
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
  |   |   | . |   |   |   |   |   |
|   |   |   |
|   |   |   |
|
|   |   |   | . |
|   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |
|
|   |   |   |
|
|
|
|
|
|
Template Sequence |   |
R | I | R | . |
P | E | T | I | A | A | E | D | I | L | H | D | L | G | I | I | S | M | . |
M | S | T | D | A | L | A | M | G | R | A | G | E | M | V | L | R | T | W | Q | T | A | D | K | M | K | K | Q | R | G | P | L | A | E | E | K | N | G | S | D | N | F | R | L | K | R | Y | V | S | K | Y | T | I | N | P | A | I |
Template Known Secondary structure |   |
 | S |
| . |  |  |  |  |  |  |  |  |  |  |  |  | T | T | S | S |
| B | . |
|
|
|
| B | T | T | S | S |
| T | T |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| S |
| T | T |
|
| S | S |
|
|  |  |  |  |  |  |  |  |  | T | T | T |  |  |  |  |  |
Template Predicted Secondary structure |   |
|
|
| . |
|
|
|
|
|
|  |  |  |  |  |  |
|
|
|  |  |  | . |  |  |
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |
|
|
|  |  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
339 | 340 | . | |
. | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | |
360 | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | . | . | . | . | . | . | . | . | 400 | . | . | . | . | . | . | . | . | . | 410 | . | . | . | . | . | . |
  |
  |   |
303 | . | . | . | . | . | |
|
|
|
|
|
|
|
|
|
. | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . |
Predicted Secondary structure |   |
 |
|
|
|
|
| . | . | . | . | . | . | . | . | . | . |
|
|  |  |  |  |  |
|
|
|
|  |  |  |
|  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |
|
|  |  |  |
|
Query SS confidence |   |
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
F | Y | G | L | P | V | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
N | D | T | F | I | E | L | V | R | E | E | Q | Q | V | A | E | S | I | A | L | T | D | D | T | L | V | P | F | L | A | G | E | T | V | R | W | S | V | K | Q |
Query Conservation |   |
|   |
|
|   |   | . | . | . | . | . | . | . | . | . | . |   |
|   |   |
|   |
|   |   |   |   |   |   |
|   |   |   |   |   |   |
|
|   |   |   |
|
|
|   |   |
|   |   |
|   |   |   |
|   |   |
Alig confidence |   |
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
  |
|
|
|   |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |
|   | . |   |   |   |   | . |   |   |   |   |   |   |   |   |   |   |   |
Template Sequence |   |
A | Q | G | I | A | H | E | V | G | S | I | E | E | G | K | F | A | D | G | D | L | I | H | D | T | N | I | T | F | M | S | K | S | S | I | Q | Q | G | V | . |
P | A | K | L | . |
G | L | K | R | R | I | G | T | V | K | N |
Template Known Secondary structure |   |
 |  | T |
| T | T | T | S | S | S |
|
| T | T | S |
|
|
|
| T |  |  |  |  | S |
|  |  |  |  |
|  |  |  |  |  | T | T |  | . |  |  |  |  | . | T |
|
| S |  |  |  |  |
|
|
|
Template Predicted Secondary structure |   |
 |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |
|
| . |
|
|
|
| . |
|
|
|  |  |  |  |  |  |
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
417 | . | . | 420 | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . | |
. | . | . | . | |
460 | . | . | . | . | . | . | . | . | . | 470 |
  |