Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	Y	S	S	I	F	S	M	L	S	F	F	I	L	F	A	C	N	E	T	A	V	Y	G	S	D	E	N	I	I	F	M	R	Y	V	E	K	L	H	L	D	K	Y	S	V	K	N	T	V	K	T	E	T	M	A	I	Q	L	A
Secondary structure
SS confidence
Disorder		?	?	?																					?														?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	I	Y	V	R	Y	R	Y	G	E	R	I	A	E	E	E	K	P	Y	L	I	T	E	L	P	D	S	W	V	V	E	G	A	K	L	P	Y	E	V	A	G	G	V	F	I	I	E	I	N	K	K	N	G	C	V	L	N	F	L	H
Secondary structure
SS confidence
Disorder																																			?	?	?	?	?	?	?																				?
Disorder confidence
		.	.
Sequence		S	K
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1f0c chain B Region: 104 - 121 Aligned: 18 Modelled: 18 Confidence: 12.4% Identity: 28% PDB header:viral protein Chain: B: PDB Molecule:ice inhibitor; PDBTitle: structure of the viral serpin crma Phyre2 PDB 3c0n chain A domain 1 Region: 79 - 93 Aligned: 15 Modelled: 15 Confidence: 11.2% Identity: 33% Fold: C-type lectin-like Superfamily: C-type lectin-like Family: Aerolysin/Pertussis toxin (APT) domain Phyre2 PDB 2vp7 chain B Region: 49 - 67 Aligned: 19 Modelled: 19 Confidence: 10.6% Identity: 26% PDB header:gene regulation Chain: B: PDB Molecule:b-cell cll/lymphoma 9 protein; PDBTitle: decoding of methylated histone h3 tail by the pygo-bcl9 wnt2 signaling complex Phyre2 PDB 2oai chain A domain 1 Region: 76 - 94 Aligned: 19 Modelled: 19 Confidence: 10.3% Identity: 21% Fold: FAD-binding/transporter-associated domain-like Superfamily: FAD-binding/transporter-associated domain-like Family: CorC/HlyC domain-like Phyre2 PDB 2yrm chain A Region: 16 - 21 Aligned: 6 Modelled: 6 Confidence: 10.1% Identity: 67% PDB header:gene regulation Chain: A: PDB Molecule:b-cell lymphoma 6 protein; PDBTitle: solution structure of the 1st zf-c2h2 domain from human b-2 cell lymphoma 6 protein Phyre2 PDB 2vpd chain B Region: 49 - 67 Aligned: 19 Modelled: 19 Confidence: 10.0% Identity: 26% PDB header:gene regulation Chain: B: PDB Molecule:b-cell cll/lymphoma 9 protein; PDBTitle: decoding of methylated histone h3 tail by the pygo-bcl9 wnt2 signaling complex Phyre2 PDB 1ept chain A Region: 69 - 99 Aligned: 31 Modelled: 31 Confidence: 9.2% Identity: 19% PDB header:hydrolase (serine protease) Chain: A: PDB Molecule:porcine e-trypsin; PDBTitle: refined 1.8 angstroms resolution crystal structure of2 porcine epsilon-trypsin Phyre2 PDB 2vpd chain D Region: 49 - 67 Aligned: 19 Modelled: 19 Confidence: 9.0% Identity: 26% PDB header:gene regulation Chain: D: PDB Molecule:b-cell cll/lymphoma 9 protein; PDBTitle: decoding of methylated histone h3 tail by the pygo-bcl9 wnt2 signaling complex Phyre2 PDB 2fa8 chain A domain 1 Region: 93 - 116 Aligned: 19 Modelled: 24 Confidence: 8.5% Identity: 32% Fold: Thioredoxin fold Superfamily: Thioredoxin-like Family: Selenoprotein W-related Phyre2 PDB 2obk chain E Region: 93 - 116 Aligned: 19 Modelled: 24 Confidence: 7.8% Identity: 32% PDB header:structural genomics, unknown function Chain: E: PDB Molecule:selt/selw/selh selenoprotein domain; PDBTitle: x-ray structure of the putative se binding protein from pseudomonas2 fluorescens. northeast structural genomics consortium target plr6. Phyre2 PDB 3thd chain D Region: 76 - 105 Aligned: 28 Modelled: 30 Confidence: 7.6% Identity: 21% PDB header:hydrolase Chain: D: PDB Molecule:beta-galactosidase; PDBTitle: crystal structure of human beta-galactosidase in complex with 1-2 deoxygalactonojirimycin Phyre2 PDB 2p13 chain A domain 1 Region: 76 - 93 Aligned: 18 Modelled: 18 Confidence: 7.2% Identity: 22% Fold: FAD-binding/transporter-associated domain-like Superfamily: FAD-binding/transporter-associated domain-like Family: CorC/HlyC domain-like Phyre2 PDB 2npb chain A Region: 85 - 117 Aligned: 28 Modelled: 33 Confidence: 6.4% Identity: 25% PDB header:oxidoreductase Chain: A: PDB Molecule:selenoprotein w; PDBTitle: nmr solution structure of mouse selw Phyre2 1 c1f0cB_ 2 d3c0na1 3 c2vp7B_ 4 d2oaia1 5 c2yrmA_ 6 c2vpdB_ 7 c1eptA_ 8 c2vpdD_ 9 d2fa8a1 10 c2obkE_ 11 c3thdD_ 12 d2p13a1 13 c2npbA_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1f0cB_ 12.4 28 PDB header:viral protein Chain: B: PDB Molecule:ice inhibitor; PDBTitle: structure of the viral serpin crma 2 d3c0na1 11.2 33 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:Aerolysin/Pertussis toxin (APT) domain 3 c2vp7B_ 10.6 26 PDB header:gene regulation Chain: B: PDB Molecule:b-cell cll/lymphoma 9 protein; PDBTitle: decoding of methylated histone h3 tail by the pygo-bcl9 wnt2 signaling complex 4 d2oaia1 10.3 21 Fold:FAD-binding/transporter-associated domain-like Superfamily:FAD-binding/transporter-associated domain-like Family:CorC/HlyC domain-like 5 c2yrmA_ 10.1 67 PDB header:gene regulation Chain: A: PDB Molecule:b-cell lymphoma 6 protein; PDBTitle: solution structure of the 1st zf-c2h2 domain from human b-2 cell lymphoma 6 protein 6 c2vpdB_ 10.0 26 PDB header:gene regulation Chain: B: PDB Molecule:b-cell cll/lymphoma 9 protein; PDBTitle: decoding of methylated histone h3 tail by the pygo-bcl9 wnt2 signaling complex 7 c1eptA_ 9.2 19 PDB header:hydrolase (serine protease) Chain: A: PDB Molecule:porcine e-trypsin; PDBTitle: refined 1.8 angstroms resolution crystal structure of2 porcine epsilon-trypsin 8 c2vpdD_ 9.0 26 PDB header:gene regulation Chain: D: PDB Molecule:b-cell cll/lymphoma 9 protein; PDBTitle: decoding of methylated histone h3 tail by the pygo-bcl9 wnt2 signaling complex 9 d2fa8a1 8.5 32 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Selenoprotein W-related 10 c2obkE_ 7.8 32 PDB header:structural genomics, unknown function Chain: E: PDB Molecule:selt/selw/selh selenoprotein domain; PDBTitle: x-ray structure of the putative se binding protein from pseudomonas2 fluorescens. northeast structural genomics consortium target plr6. 11 c3thdD_ 7.6 21 PDB header:hydrolase Chain: D: PDB Molecule:beta-galactosidase; PDBTitle: crystal structure of human beta-galactosidase in complex with 1-2 deoxygalactonojirimycin 12 d2p13a1 7.2 22 Fold:FAD-binding/transporter-associated domain-like Superfamily:FAD-binding/transporter-associated domain-like Family:CorC/HlyC domain-like 13 c2npbA_ 6.4 25 PDB header:oxidoreductase Chain: A: PDB Molecule:selenoprotein w; PDBTitle: nmr solution structure of mouse selw

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0