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Job DescriptionP37631
Confidence99.62%DateThu Jan 5 11:56:04 GMT 2012
Rank78Aligned Residues336
% Identity16%Templatec2v1dA_
PDB info PDB header:oxidoreductase/repressorChain: A: PDB Molecule:lysine-specific histone demethylase 1; PDBTitle: structural basis of lsd1-corest selectivity in histone h32 recognition
Resolution3.10 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   2.......10.........20.........30.........40.........50.........60.........70.........80.
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Query Sequence  ERFDAIIIGAGAAGMFCSALAGQAGRRVLLIDNGKKPGRKILMSGGGRCNFTNLYVEPGAYLSQNPHFCKSALARFTQWD
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Template Conservation    
 






 


 

  
   
  
 



  
 


  
    
   
 
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Template Sequence  KTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVV. . . . . . . . . . . . . . . TGLGGNP
Template Known Secondary structure 

S

STT

SSSSS
TT

TTSS

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SBT
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   277..280.........290.........300.........310.........320.........330.... .....340.
 
   82.......90.........100.........110.........120...
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Query Sequence  FIDLVNKHGIAWHEKTLGQLFCDDSAQQIVDMLVDECEKGNV. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Sequence  MAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEK
Template Known Secondary structure  TT








B
TTSSB

TS


TT
B
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   342.......350.........360.........370.........380.........390.........400.........410.........420.
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                                                                                  
Template Sequence  HVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQ
Template Known Secondary structure  S
SS

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   422.......430.........440.........450.........460.........470.........480.........490.........500.
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                             
                                
    
  
       
   
Template Sequence  GKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEG
Template Known Secondary structure  TTS


S
SS
TTS
TTTBBTTTTTTTGGG

BS

TT
TTTT
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   502.......510.........520.........530.........540.........550.........560.........570.........580.
 
   124.....130.........140.........150.........160.........170.........180.........190.........200..
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Query Sequence  . TFRLRSEVLSVAKDETGFTLDLNGMTVGCEKLVIATGGLSMPGLGASPFGYKIAEQFGLNVLPTRAGLVPFTLHKPLLE
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Template Conservation    
     
  
                         
 

 
 
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Template Sequence  LDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGV. . . . . . . . . . . . LKQQPPAVQFVPPLPEWKTS
Template Known Secondary structure 


STTSSSTT
S


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SS
SSS


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   582.......590.........600.........610.........620......... 630.........640.........
 
   203......210.........220.........230.........240.........250.........260.........270.........280..
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Query Sequence  ELQVLAGVAVPSVITAENGTVFRENLLFTHRGLSGPAVLQISSYWQPGEFVSINLLPDVDLETFLNEQRNAHPNQSLKNT
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Template Conservation 

     
    
 
 
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Template Sequence  AVQRMGFGNLNKVVLCFD. . . . . . . . . . . . . . . . . . . . . . . RVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLAL
Template Known Secondary structure  S



S.......................S

S
TT




SSSTTTTTT

SSSS
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   650.........660....... ..670.........680.........690.........700......
 
   283......290.........300.........310.........320.........330.........340.....
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Query Sequence  LAVHLPKRLVERLQQLGQIPDVSLKQLNVRDQQALISTLTDWRVQPNGTEGYRTAEVTLGGVD. . . . . . . . . . . . . . . . .
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Template Conservation    
  
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Template Sequence  VAGEAAGIM. . . . . . . ENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQP
Template Known Secondary structure 
.......TTS

TTTS


S

TTT
TTTSSS

BTT

S
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   707..710..... ....720.........730.........740.........750.........760.........770.........
 
   346...350.........360.........370.........380.........390.......
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Query Sequence  TNELSSRTMEARKVPGLYFIGEVMDVTGWLGGYNFQWAWSSAWACAQDLIAA
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Template Conservation             
 
  
 



 
    

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Template Sequence  ITPGPSIPGAPQPIPRLFFAGEHTIRNYPA. . . TVHGALLSGLREAGRIADQ
Template Known Secondary structure  B



SSTTS






SGGG
TTSTT...S
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   780.........790.........800......... 810.........820........
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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