Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	V	S	A	L	Y	A	V	L	S	A	L	L	L	M	K	F	S	F	D	V	V	R	L	R	M	Q	Y	R	V	A	Y	G	D	G	G	F	S	E	L	Q	S	A	I	R	I	H	G	N	A	V	E	Y	I	P	I	A	I	V	L
Secondary structure
SS confidence
Disorder		?																														?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		M	L	F	M	E	M	N	G	A	E	T	W	M	V	H	I	C	G	I	V	L	L	A	G	R	L	M	H	Y	Y	G	F	H	H	R	L	F	R	W	R	R	S	G	M	S	A	T	W	C	A	L	L	L	M	V	L	A	N	L	W
Secondary structure
SS confidence
Disorder																																					?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.
Sequence		Y	M	P	W	E	L	V	F	S	L	R
Secondary structure
SS confidence
Disorder									?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2pno chain L Region: 2 - 125 Aligned: 122 Modelled: 124 Confidence: 100.0% Identity: 25% PDB header:lyase Chain: L: PDB Molecule:leukotriene c4 synthase; PDBTitle: crystal structure of human leukotriene c4 synthase Phyre2 PDB 2uui chain A domain 1 Region: 2 - 125 Aligned: 122 Modelled: 124 Confidence: 100.0% Identity: 25% Fold: MAPEG domain-like Superfamily: MAPEG domain-like Family: MAPEG domain Phyre2 PDB 2q7r chain A domain 1 Region: 3 - 120 Aligned: 116 Modelled: 114 Confidence: 100.0% Identity: 13% Fold: MAPEG domain-like Superfamily: MAPEG domain-like Family: MAPEG domain Phyre2 PDB 2h8a chain A domain 1 Region: 2 - 116 Aligned: 113 Modelled: 115 Confidence: 100.0% Identity: 18% Fold: MAPEG domain-like Superfamily: MAPEG domain-like Family: MAPEG domain Phyre2 PDB 3dww chain A Region: 2 - 126 Aligned: 125 Modelled: 125 Confidence: 100.0% Identity: 18% PDB header:isomerase Chain: A: PDB Molecule:prostaglandin e synthase; PDBTitle: electron crystallographic structure of human microsomal2 prostaglandin e synthase 1 Phyre2 PDB 2knc chain A Region: 2 - 39 Aligned: 38 Modelled: 38 Confidence: 11.4% Identity: 13% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 1znf chain A Region: 36 - 49 Aligned: 14 Modelled: 14 Confidence: 6.5% Identity: 36% PDB header:zinc finger dna binding domain Chain: A: PDB Molecule:31st zinc finger from xfin; PDBTitle: three-dimensional solution structure of a single zinc2 finger dna-binding domain Phyre2 PDB 1znf chain A Region: 36 - 49 Aligned: 14 Modelled: 14 Confidence: 6.5% Identity: 36% Fold: beta-beta-alpha zinc fingers Superfamily: beta-beta-alpha zinc fingers Family: Classic zinc finger, C2H2 Phyre2 PDB 3pmd chain A Region: 17 - 34 Aligned: 18 Modelled: 18 Confidence: 6.2% Identity: 28% PDB header:lipid binding protein Chain: A: PDB Molecule:conserved domain protein; PDBTitle: crystal structure of the sporulation inhibitor pxo1-118 from bacillus2 anthracis Phyre2 PDB 1yku chain B Region: 17 - 34 Aligned: 18 Modelled: 18 Confidence: 6.0% Identity: 22% PDB header:unknown function Chain: B: PDB Molecule:hypothetical protein pxo2-61; PDBTitle: crystal structure of a sensor domain homolog Phyre2 1 c2pnoL_ 2 d2uuia1 3 d2q7ra1 4 d2h8aa1 5 c3dwwA_ 6 c2kncA_ 7 c1znfA_ 8 d1znfa_ 9 c3pmdA_ 10 c1ykuB_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2pnoL_ 100.0 25 PDB header:lyase Chain: L: PDB Molecule:leukotriene c4 synthase; PDBTitle: crystal structure of human leukotriene c4 synthase 2 d2uuia1 100.0 25 Fold:MAPEG domain-like Superfamily:MAPEG domain-like Family:MAPEG domain 3 d2q7ra1 100.0 13 Fold:MAPEG domain-like Superfamily:MAPEG domain-like Family:MAPEG domain 4 d2h8aa1 100.0 18 Fold:MAPEG domain-like Superfamily:MAPEG domain-like Family:MAPEG domain 5 c3dwwA_ 100.0 18 PDB header:isomerase Chain: A: PDB Molecule:prostaglandin e synthase; PDBTitle: electron crystallographic structure of human microsomal2 prostaglandin e synthase 1 6 c2kncA_ 11.4 13 PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex 7 c1znfA_ 6.5 36 PDB header:zinc finger dna binding domain Chain: A: PDB Molecule:31st zinc finger from xfin; PDBTitle: three-dimensional solution structure of a single zinc2 finger dna-binding domain 8 d1znfa_ 6.5 36 Fold:beta-beta-alpha zinc fingers Superfamily:beta-beta-alpha zinc fingers Family:Classic zinc finger, C2H2 9 c3pmdA_ 6.2 28 PDB header:lipid binding protein Chain: A: PDB Molecule:conserved domain protein; PDBTitle: crystal structure of the sporulation inhibitor pxo1-118 from bacillus2 anthracis 10 c1ykuB_ 6.0 22 PDB header:unknown function Chain: B: PDB Molecule:hypothetical protein pxo2-61; PDBTitle: crystal structure of a sensor domain homolog

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0