Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	D	F	T	L	S	K	S	L	F	S	G	K	Y	R	N	A	S	S	T	P	G	N	I	A	Y	A	L	F	V	L	F	C	F	W	A	G	A	Q	L	L	N	L	L	V	H	A	P	G	V	Y	E	R	L	M	Q	V	Q	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?					?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.
Sequence		T	G	R	P	R	V	E	I	G	L	G	V	G	T	I	F	G	L	I	P	F	L	V	G	C	L	I	F	A	V	V	A	L	W	L	H	W	R	H	R	R	Q
Secondary structure
SS confidence
Disorder		?	?	?	?																																				?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1b9u chain A Region: 17 - 34 Aligned: 18 Modelled: 18 Confidence: 40.2% Identity: 56% PDB header:hydrolase Chain: A: PDB Molecule:protein (atp synthase); PDBTitle: membrane domain of the subunit b of the e.coli atp synthase Phyre2 PDB 1q90 chain N Region: 1 - 10 Aligned: 10 Modelled: 10 Confidence: 13.3% Identity: 40% Fold: Single transmembrane helix Superfamily: PetN subunit of the cytochrome b6f complex Family: PetN subunit of the cytochrome b6f complex Phyre2 PDB 3mq1 chain A Region: 42 - 60 Aligned: 19 Modelled: 19 Confidence: 10.5% Identity: 32% PDB header:allergen Chain: A: PDB Molecule:mite allergen der p 5; PDBTitle: crystal structure of dust mite allergen der p 5 Phyre2 PDB 2jmh chain A Region: 42 - 60 Aligned: 19 Modelled: 19 Confidence: 9.5% Identity: 21% PDB header:allergen Chain: A: PDB Molecule:mite allergen blo t 5; PDBTitle: nmr solution structure of blo t 5, a major mite allergen2 from blomia tropicalis Phyre2 PDB 2i7n chain A domain 2 Region: 69 - 85 Aligned: 17 Modelled: 17 Confidence: 7.7% Identity: 53% Fold: Ribonuclease H-like motif Superfamily: Actin-like ATPase domain Family: Fumble-like Phyre2 PDB 2axt chain M domain 1 Region: 23 - 63 Aligned: 26 Modelled: 26 Confidence: 5.6% Identity: 50% Fold: Single transmembrane helix Superfamily: Photosystem II reaction center protein M, PsbM Family: PsbM-like Phyre2 PDB 2roc chain B Region: 38 - 56 Aligned: 19 Modelled: 19 Confidence: 5.4% Identity: 42% PDB header:apoptosis Chain: B: PDB Molecule:bcl-2-binding component 3; PDBTitle: solution structure of mcl-1 complexed with puma Phyre2 1 c1b9uA_ 2 d1q90n_ 3 c3mq1A_ 4 c2jmhA_ 5 d2i7na2 6 d2axtm1 7 c2rocB_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1b9uA_ 40.2 56 PDB header:hydrolase Chain: A: PDB Molecule:protein (atp synthase); PDBTitle: membrane domain of the subunit b of the e.coli atp synthase 2 d1q90n_ 13.3 40 Fold:Single transmembrane helix Superfamily:PetN subunit of the cytochrome b6f complex Family:PetN subunit of the cytochrome b6f complex 3 c3mq1A_ 10.5 32 PDB header:allergen Chain: A: PDB Molecule:mite allergen der p 5; PDBTitle: crystal structure of dust mite allergen der p 5 4 c2jmhA_ 9.5 21 PDB header:allergen Chain: A: PDB Molecule:mite allergen blo t 5; PDBTitle: nmr solution structure of blo t 5, a major mite allergen2 from blomia tropicalis 5 d2i7na2 7.7 53 Fold:Ribonuclease H-like motif Superfamily:Actin-like ATPase domain Family:Fumble-like 6 d2axtm1 5.6 50 Fold:Single transmembrane helix Superfamily:Photosystem II reaction center protein M, PsbM Family:PsbM-like 7 c2rocB_ 5.4 42 PDB header:apoptosis Chain: B: PDB Molecule:bcl-2-binding component 3; PDBTitle: solution structure of mcl-1 complexed with puma

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0