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Job DescriptionP33916
Confidence100.00%DateThu Jan 5 11:52:44 GMT 2012
Rank2Aligned Residues474
% Identity36%Templatec3g5uB_
PDB info PDB header:membrane proteinChain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding
Resolution3.80 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   6...10.........20.........30.........40.........50.........60.........70.........80.....
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Query Sequence  LAIENLSVGFRHQQTVRTVVNDVSLQIEAGETLALVGESGSGKSVTALSILRLLPSPPVEYLSGDIRFHGESLLHASDQT
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Template Sequence  LEFKNIHFSYPSRKE. VQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLY. . . . . DPLDGMVSIDGQDIRTINVRY
Template Known Secondary structure 

SSTTS.

S
TT


SSTTTTTSS.....

STTGGGS
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   388.390.........400.. .......410.........420.........430.........440 .........450.........460.
 
   86...90.........100.........110.........120.........130.........140.........150 .......
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Query Sequence  LRGVRGNKIAMIFQEPMVSLNPLHTLEKQLYEVLSLHRGMRREAARGEILNCLDRVGIRQAAKRL. . . . . . . . TDYPHQL
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Template Sequence  LREI. . . . IGVVSQEPV. . LFATTIAENIRYGREDVTM. . . . . . . . DEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQL
Template Known Secondary structure  ....SS

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SS

SS

........TT
TTSTTGGG


SSSS
SS
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   462... ....470.... .....480.........490... ......500.........510.........520.......
 
   158.160.........170.........180.........190.........200.........210.........220.........230.......
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Query Sequence  SGGERQRVMIAMALLTRPELLIADEPTTALDVSVQAQILQLLRELQGELNMGMLFITHNLSIVRKLAHRVAVMQNGRCVE
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Template Sequence  SGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKARE. . GRTTIVIAHRLSTVR. NADVIAGFDGGVIVE
Template Known Secondary structure 


SBTT
SS
TT..SS
S
T.T
S
SSS



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   528.530.........540.........550.........560.........570.... .....580......... 590.........600....
 
   238.240.........250.........260.........270.....
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Query Sequence  QNYAATLFASPTHPYTQKLLNSEPSGDPVPLPEPASTL. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Conservation   
    
                                               
                         
Template Sequence  QGNHDELMREKGIYFKLVMTQTLDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPP
Template Known Secondary structure 
TST









TTT



SS
ST
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   605....610.........620.........630.........640.........650.........660.........670.........680....
 
  
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                        
                   
   
   
               
 
  
   
    
Template Sequence  ETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQV
Template Known Secondary structure  T

S
S

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   742.......750.........760.........770.........780.........790.........800.........810.........820.
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation         
   
          
        
 

 
    
                               
 
 
  
Template Sequence  KGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFR
Template Known Secondary structure  SS
STTTT
T
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   822.......830.........840.........850.........860.........870.........880.........890.........900.
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation   

                                                   
  
                      
Template Sequence  TVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAAAFRFGAYLVTQQLMTFENVLLVFSAIVFGA
Template Known Secondary structure  TTTT
SS

TTTT
S
STT
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   902.......910.........920.........930.........940.........950.........960.........970.........980.
 
   276...280.........290.........300......
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . LDVEQLQVAFPIRKGILKRIVDHNVVVKNIS
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Template Sequence  MAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTR. . . . . . . . PSIPVLQGLS
Template Known Secondary structure  TSSSS
SS




SS
S




TTT





S
G........GG

SS

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   982.......990.........1000.........1010.........1020.........1030.........1040... ......1050...
 
   307..310.........320.........330...... ...340.........350.........360.........370.........380.....
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Query Sequence  FTLRAGETLGLVGESGSGKSTTGLALLRLI. NSQGSIIFDGQPLQNLNRRQLLPIRHRIQVVFQDPNSSLNPRLNVLQII
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Template Sequence  LEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWL. . . RAQLGIVSQEP. . ILFDC. SIAENI
Template Known Secondary structure 
SSS
SSSTTTTSS

SSSSS
BTSS
...TTS
SS
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SS.B
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   1054.....1060.........1070.........1080.........1090.........1100..... ....1110...... ...1120. ......
 
   386...390.........400.........410.........420.... .....430.........440.........450....
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Query Sequence  EEGLRVHQPTLSAAQREQQVIAVMHEVGLDPETRHRYPA. . . . . . . . . . . EFSGGQRQRIAIARALILKPSLIILDEPTS
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Template Sequence  AYGDNSRVVS. . . . . . YEEIVRAAKEANIH. QFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATS
Template Known Secondary structure  T


SS



......T
.SSTTTGGG
B
STTS
SS


SSS
SS
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   1128.1130....... ..1140.........1150. ........1160.........1170.........1180.........1190.........1200
 
   455....460.........470.........480.........490.........500.........510.........520........
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Query Sequence  SLDKTVQAQILTLLKSLQQKHQLAYLFISHDLHVVRALCHQVIILRQGEVVEQGPCARVFATPQQEYTRQLLAL
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Template Sequence  ALDTESEKVVQEALDKARE. . GRTCIVIAHRLSTIQ. NADLIVVIQNGKVKEHGTHQQLLAQKGIYF. . SMVSV
Template Known Secondary structure  S

SS..SS

S
TTGGG.S
STB
S
S..
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   1201........1210......... 1220.........1230.... .....1240.........1250.........1260.... .....
 
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Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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