Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionQ9VWX9
DateTue Jan 22 11:53:03 GMT 2013
Unique Job ID04ec191dfa45c549

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c1eboE_
Top template information
PDB header:viral protein
Chain: E: PDB Molecule:ebola virus envelope protein chimera consisting
PDBTitle: crystal structure of the ebola virus membrane-fusion2 subunit, gp2, from the envelope glycoprotein ectodomain
Confidence and coverage
Confidence: 40.9% Coverage: 19%
48 residues ( 19% of your sequence) have been modelled with 40.9% confidence by the single highest scoring template.
You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.
Please note: You must be registered and logged in to use Phyrealarm.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MNRYHELSMSWEMLRDLYETWLILAIGMLVRWNRWRPLIHGMVSPLDPSLKHIVGDNERW
Secondary structure 
SS confidence 
Disorder  ???????
???
???
??
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  AGVYFGCGTLMTIMQYRSLWVRRCRHRVHILMLLSEIMLLLQLVHWIDCQLWQSFLSLFE
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  ELFIALGRGQWGSWIFCCPAAVRNLFLRGDVFDVFRLLASFAIFAVALNSTAGEWRVSLD
Secondary structure 
SS confidence 
Disorder 
?
???
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  FLLIGYFPKTSLWRQSLYVEYRSKGFEPTGSYVLLPLPPPELLIYKRMCRLCLQQLETNP
Secondary structure 
SS confidence 
Disorder 
?
??
???
?
????
Disorder confidence 
 
   .........
Sequence  THQKIQMPC
Secondary structure 
SS confidence 
Disorder  ?
???????
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 1ebo chain E

3D model

Region: 139 - 186
Aligned: 48
Modelled: 48
Confidence: 40.9%
Identity: 23%
PDB header:viral protein
Chain: E: PDB Molecule:ebola virus envelope protein chimera consisting
PDBTitle: crystal structure of the ebola virus membrane-fusion2 subunit, gp2, from the envelope glycoprotein ectodomain

Phyre2

PDB 3cm8 chain A

3D model

Region: 28 - 62
Aligned: 35
Modelled: 35
Confidence: 30.5%
Identity: 11%
PDB header:rna binding protein/transferase
Chain: A: PDB Molecule:polymerase acidic protein;
PDBTitle: a rna polymerase subunit structure from virus

Phyre2

PDB 4g2k chain B

3D model

Region: 141 - 186
Aligned: 46
Modelled: 46
Confidence: 28.9%
Identity: 17%
PDB header:viral protein
Chain: B: PDB Molecule:general control protein gcn4, envelope glycoprotein gp2
PDBTitle: crystal structure of the marburg virus gp2 ectodomain in its post-2 fusion conformation

Phyre2

PDB 1rhy chain A domain 1

3D model

Region: 117 - 130
Aligned: 14
Modelled: 14
Confidence: 19.3%
Identity: 21%
Fold: Ribosomal protein S5 domain 2-like
Superfamily: Ribosomal protein S5 domain 2-like
Family: Imidazole glycerol phosphate dehydratase

Phyre2

PDB 1tw9 chain A domain 1

3D model

Region: 51 - 91
Aligned: 40
Modelled: 41
Confidence: 16.6%
Identity: 10%
Fold: GST C-terminal domain-like
Superfamily: GST C-terminal domain-like
Family: Glutathione S-transferase (GST), C-terminal domain

Phyre2

PDB 2f1d chain A domain 1

3D model

Region: 117 - 130
Aligned: 14
Modelled: 14
Confidence: 14.1%
Identity: 7%
Fold: Ribosomal protein S5 domain 2-like
Superfamily: Ribosomal protein S5 domain 2-like
Family: Imidazole glycerol phosphate dehydratase

Phyre2

PDB 2l3n chain A

3D model

Region: 164 - 183
Aligned: 20
Modelled: 20
Confidence: 13.8%
Identity: 40%
PDB header:dna binding protein
Chain: A: PDB Molecule:dna-binding protein rap1, telomere length regulator taz1;
PDBTitle: solution structure of rap1-taz1 fusion protein

Phyre2

PDB 3csy chain J

3D model

Region: 176 - 183
Aligned: 8
Modelled: 8
Confidence: 13.7%
Identity: 63%
PDB header:immune system/viral protein
Chain: J: PDB Molecule:envelope glycoprotein gp2;
PDBTitle: crystal structure of the trimeric prefusion ebola virus glycoprotein2 in complex with a neutralizing antibody from a human survivor

Phyre2

PDB 2ae8 chain A domain 1

3D model

Region: 117 - 129
Aligned: 13
Modelled: 13
Confidence: 13.4%
Identity: 0%
Fold: Ribosomal protein S5 domain 2-like
Superfamily: Ribosomal protein S5 domain 2-like
Family: Imidazole glycerol phosphate dehydratase

Phyre2

PDB 1wr1 chain B

3D model

Region: 165 - 187
Aligned: 23
Modelled: 23
Confidence: 12.3%
Identity: 35%
PDB header:signaling protein
Chain: B: PDB Molecule:ubiquitin-like protein dsk2;
PDBTitle: the complex sturcture of dsk2p uba with ubiquitin

Phyre2

PDB 3s88 chain J

3D model

Region: 176 - 183
Aligned: 8
Modelled: 8
Confidence: 12.3%
Identity: 63%
PDB header:immune system/viral protein
Chain: J: PDB Molecule:envelope glycoprotein;
PDBTitle: crystal structure of sudan ebolavirus glycoprotein (strain gulu) bound2 to 16f6

Phyre2

PDB 2bwb chain A domain 1

3D model

Region: 165 - 185
Aligned: 21
Modelled: 21
Confidence: 11.8%
Identity: 38%
Fold: RuvA C-terminal domain-like
Superfamily: UBA-like
Family: UBA domain

Phyre2

PDB 2xsu chain A

3D model

Region: 151 - 182
Aligned: 32
Modelled: 32
Confidence: 10.4%
Identity: 25%
PDB header:oxidoreductase
Chain: A: PDB Molecule:catechol 1,2 dioxygenase;
PDBTitle: crystal structure of the a72g mutant of acinetobacter2 radioresistens catechol 1,2 dioxygenase

Phyre2

PDB 2dah chain A domain 1

3D model

Region: 165 - 183
Aligned: 19
Modelled: 19
Confidence: 10.3%
Identity: 26%
Fold: RuvA C-terminal domain-like
Superfamily: UBA-like
Family: UBA domain

Phyre2

PDB 2dbh chain A

3D model

Region: 118 - 126
Aligned: 9
Modelled: 9
Confidence: 10.3%
Identity: 22%
PDB header:signaling protein
Chain: A: PDB Molecule:tumor necrosis factor receptor superfamily
PDBTitle: solution structure of the carboxyl-terminal card-like2 domain in human tnfr-related death receptor-6

Phyre2

PDB 2cwb chain A

3D model

Region: 165 - 188
Aligned: 24
Modelled: 24
Confidence: 10.1%
Identity: 29%
PDB header:protein binding
Chain: A: PDB Molecule:chimera of immunoglobulin g binding protein g
PDBTitle: solution structure of the ubiquitin-associated domain of2 human bmsc-ubp and its complex with ubiquitin

Phyre2

PDB 1waz chain A

3D model

Region: 122 - 156
Aligned: 35
Modelled: 35
Confidence: 9.8%
Identity: 11%
PDB header:transport protein
Chain: A: PDB Molecule:merf;
PDBTitle: nmr structure determination of the bacterial mercury2 transporter, merf, in micelles

Phyre2

PDB 1k3y chain A domain 1

3D model

Region: 51 - 91
Aligned: 40
Modelled: 41
Confidence: 9.6%
Identity: 13%
Fold: GST C-terminal domain-like
Superfamily: GST C-terminal domain-like
Family: Glutathione S-transferase (GST), C-terminal domain

Phyre2

PDB 2h3o chain A

3D model

Region: 122 - 156
Aligned: 35
Modelled: 35
Confidence: 9.6%
Identity: 11%
PDB header:membrane protein
Chain: A: PDB Molecule:merf;
PDBTitle: structure of merft, a membrane protein with two trans-2 membrane helices

Phyre2

PDB 1z96 chain A domain 1

3D model

Region: 165 - 183
Aligned: 19
Modelled: 19
Confidence: 9.5%
Identity: 42%
Fold: RuvA C-terminal domain-like
Superfamily: UBA-like
Family: UBA domain

Phyre2
1
c1eboE_
2
c3cm8A_
3
c4g2kB_
4
d1rhya1
5
d1tw9a1
6
d2f1da1
7
c2l3nA_
8
c3csyJ_
9
d2ae8a1
10
c1wr1B_
11
c3s88J_
12
d2bwba1
13
c2xsuA_
14
d2daha1
15
c2dbhA_
16
c2cwbA_
17
c1wazA_
18
d1k3ya1
19
c2h3oA_
20
d1z96a1
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60



Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c1eboE_
40.9 23 PDB header:viral protein
Chain: E: PDB Molecule:ebola virus envelope protein chimera consisting
PDBTitle: crystal structure of the ebola virus membrane-fusion2 subunit, gp2, from the envelope glycoprotein ectodomain
2c3cm8A_
30.5 11 PDB header:rna binding protein/transferase
Chain: A: PDB Molecule:polymerase acidic protein;
PDBTitle: a rna polymerase subunit structure from virus
3c4g2kB_
28.9 17 PDB header:viral protein
Chain: B: PDB Molecule:general control protein gcn4, envelope glycoprotein gp2
PDBTitle: crystal structure of the marburg virus gp2 ectodomain in its post-2 fusion conformation
4d1rhya1
19.3 21 Fold:Ribosomal protein S5 domain 2-like
Superfamily:Ribosomal protein S5 domain 2-like
Family:Imidazole glycerol phosphate dehydratase
5d1tw9a1
16.6 10 Fold:GST C-terminal domain-like
Superfamily:GST C-terminal domain-like
Family:Glutathione S-transferase (GST), C-terminal domain
6d2f1da1
14.1 7 Fold:Ribosomal protein S5 domain 2-like
Superfamily:Ribosomal protein S5 domain 2-like
Family:Imidazole glycerol phosphate dehydratase
7c2l3nA_
13.8 40 PDB header:dna binding protein
Chain: A: PDB Molecule:dna-binding protein rap1, telomere length regulator taz1;
PDBTitle: solution structure of rap1-taz1 fusion protein
8c3csyJ_
13.7 63 PDB header:immune system/viral protein
Chain: J: PDB Molecule:envelope glycoprotein gp2;
PDBTitle: crystal structure of the trimeric prefusion ebola virus glycoprotein2 in complex with a neutralizing antibody from a human survivor
9d2ae8a1
13.4 0 Fold:Ribosomal protein S5 domain 2-like
Superfamily:Ribosomal protein S5 domain 2-like
Family:Imidazole glycerol phosphate dehydratase
10c1wr1B_
12.3 35 PDB header:signaling protein
Chain: B: PDB Molecule:ubiquitin-like protein dsk2;
PDBTitle: the complex sturcture of dsk2p uba with ubiquitin
11c3s88J_
12.3 63 PDB header:immune system/viral protein
Chain: J: PDB Molecule:envelope glycoprotein;
PDBTitle: crystal structure of sudan ebolavirus glycoprotein (strain gulu) bound2 to 16f6
12d2bwba1
11.8 38 Fold:RuvA C-terminal domain-like
Superfamily:UBA-like
Family:UBA domain
13c2xsuA_
10.4 25 PDB header:oxidoreductase
Chain: A: PDB Molecule:catechol 1,2 dioxygenase;
PDBTitle: crystal structure of the a72g mutant of acinetobacter2 radioresistens catechol 1,2 dioxygenase
14d2daha1
10.3 26 Fold:RuvA C-terminal domain-like
Superfamily:UBA-like
Family:UBA domain
15c2dbhA_
10.3 22 PDB header:signaling protein
Chain: A: PDB Molecule:tumor necrosis factor receptor superfamily
PDBTitle: solution structure of the carboxyl-terminal card-like2 domain in human tnfr-related death receptor-6
16c2cwbA_
10.1 29 PDB header:protein binding
Chain: A: PDB Molecule:chimera of immunoglobulin g binding protein g
PDBTitle: solution structure of the ubiquitin-associated domain of2 human bmsc-ubp and its complex with ubiquitin
17c1wazA_
9.8 11 PDB header:transport protein
Chain: A: PDB Molecule:merf;
PDBTitle: nmr structure determination of the bacterial mercury2 transporter, merf, in micelles
18d1k3ya1
9.6 13 Fold:GST C-terminal domain-like
Superfamily:GST C-terminal domain-like
Family:Glutathione S-transferase (GST), C-terminal domain
19c2h3oA_
9.6 11 PDB header:membrane protein
Chain: A: PDB Molecule:merf;
PDBTitle: structure of merft, a membrane protein with two trans-2 membrane helices
20d1z96a1
9.5 42 Fold:RuvA C-terminal domain-like
Superfamily:UBA-like
Family:UBA domain
21d1glqa1
not modelled 9.5 26 Fold:GST C-terminal domain-like
Superfamily:GST C-terminal domain-like
Family:Glutathione S-transferase (GST), C-terminal domain
22c3fybA_
not modelled 9.3 43 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:protein of unknown function (duf1244);
PDBTitle: crystal structure of a protein of unknown function (duf1244) from2 alcanivorax borkumensis
23d1ifya_
not modelled 8.7 27 Fold:RuvA C-terminal domain-like
Superfamily:UBA-like
Family:UBA domain
24c2lj2A_
not modelled 8.3 12 PDB header:membrane protein
Chain: A: PDB Molecule:merf;
PDBTitle: integral membrane core domain of the mercury transporter merf in lipid2 bilayer membranes
25c2jy5A_
not modelled 8.2 27 PDB header:signaling protein
Chain: A: PDB Molecule:ubiquilin-1;
PDBTitle: nmr structure of ubiquilin 1 uba domain
26c2lifA_
not modelled 7.9 60 PDB header:viral protein, membrane protein
Chain: A: PDB Molecule:core protein p21;
PDBTitle: solution structure of kkgf
27c3q5xA_
not modelled 7.7 14 PDB header:cell cycle
Chain: A: PDB Molecule:protein cut8;
PDBTitle: structure of proteasome tether
28d1s9aa_
not modelled 7.6 13 Fold:Prealbumin-like
Superfamily:Aromatic compound dioxygenase
Family:Aromatic compound dioxygenase
29d2o35a1
not modelled 7.5 33 Fold:SMc04008-like
Superfamily:SMc04008-like
Family:SMc04008-like
30c2o35A_
not modelled 7.5 33 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:hypothetical protein duf1244;
PDBTitle: protein of unknown function (duf1244) from sinorhizobium meliloti
31c3th1C_
not modelled 7.5 16 PDB header:oxidoreductase
Chain: C: PDB Molecule:chlorocatechol 1,2-dioxygenase;
PDBTitle: crystal structure of chlorocatechol 1,2-dioxygenase from pseudomonas2 putida
32c2f5uA_
not modelled 7.3 50 PDB header:viral protein
Chain: A: PDB Molecule:virion protein ul25;
PDBTitle: structural characterization of the ul25 dna packaging2 protein from herpes simplex virus type 1
33c3n9tA_
not modelled 7.0 22 PDB header:oxidoreductase
Chain: A: PDB Molecule:pnpc;
PDBTitle: cryatal structure of hydroxyquinol 1,2-dioxygenase from pseudomonas2 putida dll-e4
34c2boyC_
not modelled 6.9 16 PDB header:oxidoreductase
Chain: C: PDB Molecule:3-chlorocatechol 1,2-dioxygenase;
PDBTitle: crystal structure of 3-chlorocatechol 1,2-dioxygenase from2 rhodococcus opacus 1cp
35d2dnaa1
not modelled 6.7 26 Fold:RuvA C-terminal domain-like
Superfamily:UBA-like
Family:UBA domain
36d1d2ta_
not modelled 6.6 14 Fold:Acid phosphatase/Vanadium-dependent haloperoxidase
Superfamily:Acid phosphatase/Vanadium-dependent haloperoxidase
Family:Type 2 phosphatidic acid phosphatase, PAP2
37d1p94a_
not modelled 6.5 27 Fold:Ribbon-helix-helix
Superfamily:Ribbon-helix-helix
Family:CopG-like
38d1mlwa_
not modelled 6.5 18 Fold:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
Superfamily:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
Family:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
39d1fqva1
not modelled 6.5 35 Fold:F-box domain
Superfamily:F-box domain
Family:F-box domain
40c3hj8A_
not modelled 6.5 19 PDB header:oxidoreductase
Chain: A: PDB Molecule:catechol 1,2-dioxygenase;
PDBTitle: crystal structure determination of catechol 1,2-dioxygenase from2 rhodococcus opacus 1cp in complex with 4-chlorocatechol
41d1em8a_
not modelled 6.4 22 Fold:DNA polymerase III chi subunit
Superfamily:DNA polymerase III chi subunit
Family:DNA polymerase III chi subunit
42d1toha_
not modelled 6.3 24 Fold:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
Superfamily:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
Family:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
43d1ltza_
not modelled 6.3 29 Fold:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
Superfamily:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
Family:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
44d1phza2
not modelled 6.2 18 Fold:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
Superfamily:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
Family:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
45d1j8ua_
not modelled 6.1 18 Fold:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
Superfamily:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
Family:Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
46c3e2tA_
not modelled 6.0 24 PDB header:oxidoreductase
Chain: A: PDB Molecule:tryptophan 5-hydroxylase 1;
PDBTitle: the catalytic domain of chicken tryptophan hydroxylase 12 with bound tryptophan
47d1dmha_
not modelled 5.9 22 Fold:Prealbumin-like
Superfamily:Aromatic compound dioxygenase
Family:Aromatic compound dioxygenase
48c2azqA_
not modelled 5.8 25 PDB header:oxidoreductase
Chain: A: PDB Molecule:catechol 1,2-dioxygenase;
PDBTitle: crystal structure of catechol 1,2-dioxygenase from pseudomonas arvilla2 c-1
49d2cvda1
not modelled 5.7 21 Fold:GST C-terminal domain-like
Superfamily:GST C-terminal domain-like
Family:Glutathione S-transferase (GST), C-terminal domain
50c2kdrX_
not modelled 5.7 19 PDB header:viral protein, membrane protein
Chain: X: PDB Molecule:non-structural protein 4b;
PDBTitle: solution structure of hcv ns4b(227-254)
51c1rhyB_
not modelled 5.7 23 PDB header:lyase
Chain: B: PDB Molecule:imidazole glycerol phosphate dehydratase;
PDBTitle: crystal structure of imidazole glycerol phosphate dehydratase
52d1veja1
not modelled 5.6 32 Fold:RuvA C-terminal domain-like
Superfamily:UBA-like
Family:UBA domain
53d2gsra1
not modelled 5.5 16 Fold:GST C-terminal domain-like
Superfamily:GST C-terminal domain-like
Family:Glutathione S-transferase (GST), C-terminal domain
54c2x6vB_
not modelled 5.5 36 PDB header:transcription/dna
Chain: B: PDB Molecule:t-box transcription factor tbx5;
PDBTitle: crystal structure of human tbx5 in the dna-bound and dna-2 free form
55d1txna_
not modelled 5.5 33 Fold:Coproporphyrinogen III oxidase
Superfamily:Coproporphyrinogen III oxidase
Family:Coproporphyrinogen III oxidase
56c1tmxA_
not modelled 5.4 22 PDB header:oxidoreductase
Chain: A: PDB Molecule:hydroxyquinol 1,2-dioxygenase;
PDBTitle: crystal structure of hydroxyquinol 1,2-dioxygenase from2 nocardioides simplex 3e
57c2v27A_
not modelled 5.4 12 PDB header:oxidoreductase
Chain: A: PDB Molecule:phenylalanine hydroxylase;
PDBTitle: structure of the cold active phenylalanine hydroxylase from2 colwellia psychrerythraea 34h
58c3tcyA_
not modelled 5.3 29 PDB header:oxidoreductase
Chain: A: PDB Molecule:phenylalanine-4-hydroxylase;
PDBTitle: crystallographic structure of phenylalanine hydroxylase from2 chromobacterium violaceum (cpah) bound to phenylalanine in a site3 distal to the active site
59d1z0xa2
not modelled 5.2 27 Fold:Tetracyclin repressor-like, C-terminal domain
Superfamily:Tetracyclin repressor-like, C-terminal domain
Family:Tetracyclin repressor-like, C-terminal domain
60d1b4pa1
not modelled 5.1 5 Fold:GST C-terminal domain-like
Superfamily:GST C-terminal domain-like
Family:Glutathione S-transferase (GST), C-terminal domain

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite