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 Protein Homology/analogY Recognition Engine V 2.0

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Expert Mode

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One-to-one threading

Submit both a sequence and a structure. Phyre will attempt to align the sequence and structure and construct a model of your sequence

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Batch processing

Submit a file containing up to 100 sequences for automated modelling by Phyre (to increase limit contact Harry Powell)

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Use Phyre in reverse. Submit a PDB structure and search that structure against a wide range of genomes

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Search your sequence against a wide range of genomes

5795696 submissions since Feb 14 2011

Other Resources

Missense3D Portal: a suite of resources for the analysis of amino acid substitutions in proteins

GWYRE: contains modeled and experimentally determined structures of human proteins and protein complexes, annotated by phenotypic effects of genetic mutations.

Cambridge 2019 Workshop | Older Workshops | Phyre2 paper

Phyre is now FREE for commercial users!

All images and data generated by Phyre2 are free to use in any publication with acknowledgement

Accessibility Statement
Please cite: The Phyre2 web portal for protein modeling, prediction and analysis
Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]
© Structural Bioinformatics Group, Imperial College, London
Michael Sternberg 
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Phyre2 is part of Genome3D