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 Protein Homology/analogY Recognition Engine V 2.0


You must login to use expert mode

Expert Mode

One-to-one threading

Submit both a sequence and a structure. Phyre will attempt to align the sequence and structure and construct a model of your sequence

Batch processing

Submit a file containing up to 100 sequences for automated modelling by Phyre (to increase limit contact Lawrence Kelley)


Use Phyre in reverse. Submit a PDB structure and search that structure against a wide range of genomes


Search your sequence against a wide range of genomes

3770073 submissions since Feb 14 2011

Phyre is now FREE for commercial users!

All images and data generated by Phyre2 are free to use in any publication with acknowledgement

Please cite: The Phyre2 web portal for protein modeling, prediction and analysis
Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]
© Structural Bioinformatics Group, Imperial College, London
Lawrence Kelley, Michael Sternberg 
Terms and Conditions

Phyre2 is part of Genome3D