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 Protein Homology/analogY Recognition Engine V 2.0


 

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Expert Mode

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One-to-one threading

Submit both a sequence and a structure. Phyre will attempt to align the sequence and structure and construct a model of your sequence

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Batch processing

Submit a file containing up to 100 sequences for automated modelling by Phyre (to increase limit contact Harry Powell)

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BackPhyre

Use Phyre in reverse. Submit a PDB structure and search that structure against a wide range of genomes

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GenSearch

Search your sequence against a wide range of genomes


5117407 submissions since Feb 14 2011


Other Resources

Missense3D-DB: Database of missense variants or analyse the structural impact of missense variants in your own protein with Missense3D

PhyreRisk: A dynamic database to view human sequences and structures and map genetic variants

GWYRE: contains modeled and experimentally determined structures of human proteins and protein complexes, annotated by phenotypic effects of genetic mutations.

Cambridge 2019 Workshop | Older Workshops | Phyre2 paper


Covid-19 news

Half of the human population has a defective TMPRSS2 protein that significantly reduces the chance of developing severe COVID-19: see David et al. "A common TMPRSS2 variant has a protective effect against severe COVID-19" Curr Res Transl Med. 2022 May;70(2):103333, https://doi.org/10.1016/j.retram.2022.103333



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All images and data generated by Phyre2 are free to use in any publication with acknowledgement

Accessibility Statement
Please cite: The Phyre2 web portal for protein modeling, prediction and analysis
Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]
 
© Structural Bioinformatics Group, Imperial College, London
Lawrence Kelley, Michael Sternberg 
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