| ||Protein Homology/analogY Recognition Engine V 2.0|
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5218026 submissions since Feb 14 2011
Missense3D-DB: Database of missense variants or analyse the structural impact of missense variants in your own protein with Missense3D
PhyreRisk: A dynamic database to view human sequences and structures and map genetic variants
GWYRE: contains modeled and experimentally determined structures of human proteins and protein complexes, annotated by phenotypic effects of genetic mutations.
Cambridge 2019 Workshop | Older Workshops | Phyre2 paper
Half of the human population has a defective TMPRSS2 protein that significantly reduces the chance of developing severe COVID-19: see David et al. "A common TMPRSS2 variant has a protective effect against severe COVID-19" Curr Res Transl Med. 2022 May;70(2):103333, https://doi.org/10.1016/j.retram.2022.103333
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|Please cite: The Phyre2 web portal for protein modeling, prediction and analysis|
|Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]|