Standard Mode | Login for job manager, batch processing, Phyre alarm and other advanced options Retrieve Phyre Job Id   
Subscribe to Phyre at Google Groups
Visit Phyre at Google Groups
 Protein Homology/analogY Recognition Engine V 2.0


You must login to use expert mode

Expert Mode

o2o_small logo

One-to-one threading

Submit both a sequence and a structure. Phyre will attempt to align the sequence and structure and construct a model of your sequence

batch_small logo

Batch processing

Submit a file containing up to 100 sequences for automated modelling by Phyre (to increase limit contact Harry Powell)

small backphyre logo


Use Phyre in reverse. Submit a PDB structure and search that structure against a wide range of genomes

gen search icon


Search your sequence against a wide range of genomes

4760757 submissions since Feb 14 2011

Other Resources

Missense3D: Analyse structural impact of missense variants

PhyreRisk: A dynamic database to view human sequences and structures and map genetic variants

Cambridge 2019 Workshop | Older Workshops | Phyre2 paper

Covid-19 news

Half of the human population has a defective TMPRSS2 protein that significantly reduces the chance of developing severe COVID-19: read our preprint at

Position opening

If you are interested in joining the Phyre development team, please contact Prof. Michael Sternberg for further information.

Phyre is now FREE for commercial users!

All images and data generated by Phyre2 are free to use in any publication with acknowledgement

Accessibility Statement
Please cite: The Phyre2 web portal for protein modeling, prediction and analysis
Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]
© Structural Bioinformatics Group, Imperial College, London
Lawrence Kelley, Michael Sternberg 
Terms and Conditions
Structural Biology Group logo Imperial logo
BBSRC logo
Phyre2 is part of Genome3D