Email l.a.kelley@imperial.ac.uk Description A6X992 Date Sun Jul 8 11:45:03 BST 2012 Unique Job ID bdf7516587b75a89

Summary

Top model

Image coloured by rainbow N → C terminus Close Jmol

Model (left) based on template c2e5qA_ Top template information PDB header:transcription Chain: A: PDB Molecule:phd finger protein 19; PDBTitle: solution structure of the tudor domain of phd finger2 protein 19, isoform b [homo sapiens] Confidence and coverage Confidence: 23.9% Coverage: 43% 35 residues ( 43% of your sequence) have been modelled with 23.9% confidence by the single highest scoring template. You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library. Please note: You must be registered and logged in to use Phyrealarm. 3D viewing Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2e5q chain A Region: 3 - 37 Aligned: 35 Modelled: 35 Confidence: 23.9% Identity: 31% PDB header:transcription Chain: A: PDB Molecule:phd finger protein 19; PDBTitle: solution structure of the tudor domain of phd finger2 protein 19, isoform b [homo sapiens] Phyre2 PDB 2e5p chain A Region: 3 - 33 Aligned: 31 Modelled: 31 Confidence: 13.9% Identity: 26% PDB header:transcription Chain: A: PDB Molecule:phd finger protein 1; PDBTitle: solution structure of the tudor domain of phd finger2 protein 1 (phf1 protein) Phyre2 PDB 2gyc chain M domain 1 Region: 17 - 54 Aligned: 37 Modelled: 38 Confidence: 9.7% Identity: 14% Fold: Ribonuclease H-like motif Superfamily: Translational machinery components Family: Ribosomal protein L18 and S11 Phyre2 PDB 1ovy chain A Region: 17 - 49 Aligned: 32 Modelled: 33 Confidence: 9.1% Identity: 22% Fold: Ribonuclease H-like motif Superfamily: Translational machinery components Family: Ribosomal protein L18 and S11 Phyre2 PDB 1y4o chain A domain 1 Region: 19 - 41 Aligned: 23 Modelled: 23 Confidence: 7.6% Identity: 22% Fold: Profilin-like Superfamily: Roadblock/LC7 domain Family: Roadblock/LC7 domain Phyre2 PDB 2eqj chain A Region: 3 - 33 Aligned: 31 Modelled: 31 Confidence: 6.8% Identity: 19% PDB header:transcription Chain: A: PDB Molecule:metal-response element-binding transcription PDBTitle: solution structure of the tudor domain of metal-response2 element-binding transcription factor 2 Phyre2 PDB 3lzn chain A Region: 4 - 33 Aligned: 30 Modelled: 30 Confidence: 6.1% Identity: 47% PDB header:transport protein Chain: A: PDB Molecule:p19 protein; PDBTitle: crystal structure analysis of the apo p19 protein from campylobacter2 jejuni at 1.59 a at ph 9 Phyre2 PDB 2i9w chain A Region: 1 - 17 Aligned: 17 Modelled: 17 Confidence: 5.7% Identity: 47% PDB header:metal binding protein Chain: A: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of a sec-c motif containing protein (psyc_2064) from2 psychrobacter arcticus at 1.75 a resolution Phyre2 PDB 2pi6 chain A domain 2 Region: 11 - 41 Aligned: 28 Modelled: 31 Confidence: 5.7% Identity: 25% Fold: FKBP-like Superfamily: Chitinase insertion domain Family: Chitinase insertion domain Phyre2 PDB 1zhv chain A domain 2 Region: 33 - 64 Aligned: 28 Modelled: 32 Confidence: 5.5% Identity: 25% Fold: Ferredoxin-like Superfamily: ACT-like Family: Atu0741-like Phyre2 1 c2e5qA_ 2 c2e5pA_ 3 d2gycm1 4 d1ovya_ 5 d1y4oa1 6 c2eqjA_ 7 c3lznA_ 8 c2i9wA_ 9 d2pi6a2 10 d1zhva2

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0