Email l.a.kelley@imperial.ac.uk Description O74700 Date Mon Jul 2 19:10:23 BST 2012 Unique Job ID a02a9339a9a2848c

Summary

Top model

Image coloured by rainbow N → C terminus Close Jmol

Model (left) based on template c3dxrA_ Top template information PDB header:protein transport Chain: A: PDB Molecule:mitochondrial import inner membrane translocase PDBTitle: crystal structure of the yeast inter-membrane space2 chaperone assembly tim9.10 Confidence and coverage Confidence: 99.9% Coverage: 79% 69 residues ( 79% of your sequence) have been modelled with 99.9% confidence by the single highest scoring template. 3D viewing Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3dxr chain A Region: 12 - 80 Aligned: 69 Modelled: 69 Confidence: 99.9% Identity: 100% PDB header:protein transport Chain: A: PDB Molecule:mitochondrial import inner membrane translocase PDBTitle: crystal structure of the yeast inter-membrane space2 chaperone assembly tim9.10 Phyre2 PDB 2bsk chain D Region: 8 - 86 Aligned: 79 Modelled: 79 Confidence: 99.9% Identity: 22% PDB header:protein transport Chain: D: PDB Molecule:mitochondrial import inner membrane translocase PDBTitle: crystal structure of the tim9 tim10 hexameric complex Phyre2 PDB 2bsk chain A domain 1 Region: 20 - 87 Aligned: 68 Modelled: 68 Confidence: 99.9% Identity: 41% Fold: Tim10-like Superfamily: Tim10-like Family: Tim10/DDP Phyre2 PDB 3dxr chain B Region: 15 - 77 Aligned: 63 Modelled: 63 Confidence: 99.9% Identity: 21% PDB header:protein transport Chain: B: PDB Molecule:mitochondrial import inner membrane translocase PDBTitle: crystal structure of the yeast inter-membrane space2 chaperone assembly tim9.10 Phyre2 PDB 2bsk chain B domain 1 Region: 20 - 80 Aligned: 61 Modelled: 57 Confidence: 99.9% Identity: 23% Fold: Tim10-like Superfamily: Tim10-like Family: Tim10/DDP Phyre2 PDB 3cjh chain J Region: 21 - 75 Aligned: 55 Modelled: 55 Confidence: 99.8% Identity: 24% PDB header:protein transport Chain: J: PDB Molecule:mitochondrial import inner membrane translocase subunit PDBTitle: tim8-tim13 complex Phyre2 PDB 3cjh chain K Region: 25 - 75 Aligned: 47 Modelled: 51 Confidence: 99.6% Identity: 19% PDB header:protein transport Chain: K: PDB Molecule:mitochondrial import inner membrane translocase subunit PDBTitle: tim8-tim13 complex Phyre2 PDB 1ter chain A Region: 34 - 39 Aligned: 6 Modelled: 6 Confidence: 19.2% Identity: 33% PDB header:toxin Chain: A: PDB Molecule:tertiapin; PDBTitle: solution structure of tertiapin determined using nuclear2 magnetic resonance and distance geometry Phyre2 PDB 2axk chain A Region: 50 - 63 Aligned: 14 Modelled: 14 Confidence: 16.9% Identity: 14% PDB header:toxin Chain: A: PDB Molecule:discrepin; PDBTitle: solution structure of discrepin, a scorpion venom toxin2 blocking k+ channels. Phyre2 PDB 2p4f chain A Region: 44 - 63 Aligned: 20 Modelled: 20 Confidence: 13.1% Identity: 10% PDB header:chaperone Chain: A: PDB Molecule:similar to sp p32453 saccharomyces cerevisiae ynl315c Phyre2 PDB 1xg2 chain B Region: 40 - 79 Aligned: 40 Modelled: 40 Confidence: 10.8% Identity: 20% PDB header:hydrolase/hydrolase inhibitor Chain: B: PDB Molecule:pectinesterase inhibitor; PDBTitle: crystal structure of the complex between pectin2 methylesterase and its inhibitor protein Phyre2 PDB 1pvz chain A Region: 33 - 44 Aligned: 12 Modelled: 12 Confidence: 9.9% Identity: 17% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: Scorpion toxin-like Family: Short-chain scorpion toxins Phyre2 PDB 2plx chain B Region: 53 - 59 Aligned: 7 Modelled: 7 Confidence: 8.4% Identity: 29% PDB header:hydrolase Chain: B: PDB Molecule:peptide inhibitor; PDBTitle: trypsin complexed to a synthetic peptide from veronica hederifolia Phyre2 PDB 2cmy chain B Region: 53 - 60 Aligned: 8 Modelled: 7 Confidence: 7.1% Identity: 25% PDB header:hydrolase Chain: B: PDB Molecule:veronica hederifolia trypsin inhibitor; PDBTitle: crystal complex between bovine trypsin and veronica2 hederifolia trypsin inhibitor Phyre2 PDB 2cmy chain B domain 1 Region: 53 - 60 Aligned: 8 Modelled: 7 Confidence: 7.1% Identity: 25% Fold: Toxic hairpin Superfamily: VhTI-like Family: VhTI-like Phyre2 PDB 2k42 chain B Region: 65 - 85 Aligned: 21 Modelled: 21 Confidence: 6.2% Identity: 14% PDB header:signaling protein Chain: B: PDB Molecule:espfu; PDBTitle: solution structure of the gtpase binding domain of wasp in2 complex with espfu, an ehec effector Phyre2 PDB 1l0l chain H Region: 55 - 62 Aligned: 8 Modelled: 8 Confidence: 6.1% Identity: 13% Fold: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) Superfamily: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) Family: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) Phyre2 PDB 1ppj chain H Region: 55 - 62 Aligned: 8 Modelled: 8 Confidence: 5.9% Identity: 13% Fold: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) Superfamily: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) Family: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) Phyre2 PDB 3ab6 chain A Region: 51 - 65 Aligned: 15 Modelled: 15 Confidence: 5.4% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:lysozyme; PDBTitle: crystal structure of nag3 bound lysozyme from meretrix lusoria Phyre2 PDB 3cx5 chain F domain 1 Region: 55 - 62 Aligned: 8 Modelled: 8 Confidence: 5.2% Identity: 0% Fold: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) Superfamily: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) Family: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) Phyre2 1 c3dxrA_ 2 c2bskD_ 3 d2bska1 4 c3dxrB_ 5 d2bskb1 6 c3cjhJ_ 7 c3cjhK_ 8 c1terA_ 9 c2axkA_ 10 c2p4fA_ 11 c1xg2B_ 12 d1pvza_ 13 c2plxB_ 14 c2cmyB_ 15 d2cmyb1 16 c2k42B_ 17 d1l0lh_ 18 d1ppjh_ 19 c3ab6A_ 20 d3cx5f1 21

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0