Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.
Sequence		M	S	K	R	M	H	S	H	S	I	A	W	R	K	R	V	I	D	K	A	I	I	V	L	G	A	L	I	A	L	L	E	L	I	R	F	L	L	Q	L	L	N
Secondary structure
SS confidence
Disorder		?	?	?	?																																					?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2b2a chain A Region: 14 - 25 Aligned: 12 Modelled: 12 Confidence: 18.5% Identity: 67% PDB header:transferase Chain: A: PDB Molecule:telomerase reverse transcriptase; PDBTitle: crystal structure of the ten domain of the telomerase2 reverse transcriptase Phyre2 PDB 2afv chain B Region: 1 - 35 Aligned: 35 Modelled: 35 Confidence: 9.9% Identity: 31% PDB header:isomerase Chain: B: PDB Molecule:cobalamin biosynthesis precorrin isomerase; PDBTitle: the crystal structure of putative precorrin isomerase cbic2 in cobalamin biosynthesis Phyre2 PDB 1v9c chain A Region: 1 - 35 Aligned: 35 Modelled: 35 Confidence: 9.8% Identity: 37% Fold: Flavodoxin-like Superfamily: Precorrin-8X methylmutase CbiC/CobH Family: Precorrin-8X methylmutase CbiC/CobH Phyre2 PDB 2klu chain A Region: 20 - 38 Aligned: 19 Modelled: 19 Confidence: 8.5% Identity: 42% PDB header:immune system, membrane protein Chain: A: PDB Molecule:t-cell surface glycoprotein cd4; PDBTitle: nmr structure of the transmembrane and cytoplasmic domains2 of human cd4 Phyre2 PDB 2auh chain B Region: 11 - 15 Aligned: 5 Modelled: 5 Confidence: 6.5% Identity: 80% PDB header:transferase/signaling protein Chain: B: PDB Molecule:growth factor receptor-bound protein 14; PDBTitle: crystal structure of the grb14 bps region in complex with2 the insulin receptor tyrosine kinase Phyre2 1 c2b2aA_ 2 c2afvB_ 3 d1v9ca_ 4 c2kluA_ 5 c2auhB_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2b2aA_ 18.5 67 PDB header:transferase Chain: A: PDB Molecule:telomerase reverse transcriptase; PDBTitle: crystal structure of the ten domain of the telomerase2 reverse transcriptase 2 c2afvB_ 9.9 31 PDB header:isomerase Chain: B: PDB Molecule:cobalamin biosynthesis precorrin isomerase; PDBTitle: the crystal structure of putative precorrin isomerase cbic2 in cobalamin biosynthesis 3 d1v9ca_ 9.8 37 Fold:Flavodoxin-like Superfamily:Precorrin-8X methylmutase CbiC/CobH Family:Precorrin-8X methylmutase CbiC/CobH 4 c2kluA_ 8.5 42 PDB header:immune system, membrane protein Chain: A: PDB Molecule:t-cell surface glycoprotein cd4; PDBTitle: nmr structure of the transmembrane and cytoplasmic domains2 of human cd4 5 c2auhB_ 6.5 80 PDB header:transferase/signaling protein Chain: B: PDB Molecule:growth factor receptor-bound protein 14; PDBTitle: crystal structure of the grb14 bps region in complex with2 the insulin receptor tyrosine kinase

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0