Structural Bioinformatics Group
Division of Molecular Biosciences
Faculty of Natural Sciences

ConFunc - Conserved residue Function Prediction Server

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ConFunc Example Results

view the full results page for this example:
or work through the explanation of the results page below.


The Top of The Results Page 

  • As your job runs the results page will continue to be updated. At the top of the page the status is shown.
  • The submission details are also printed for information as shown in the figure below.


Results Data Files 

  • The first set of results contain the data files that ConFunc has generated during the prediction process. They consist of:
    • PSI-BLAST output
    • MUSLCE alignment of annotated sequences
    • MUSCLE alignment of annotated sequences (with gaps in the query sequence removed)
  • The number of annotated homolouges identified is also displayed.

    As shown below, each of these can be clicked on to download the relevant file.

  • If a job has not been successful then a message should be displayed informing you and the option to download files
    will not be displayed.

ConFunc data files


GO Predictions 

  • Finally on the results page the predicted and rejected GO terms are displayed. The predicted terms are shown first.
  • For each GO term the following are displayed:
    • a description of its function
    • its level (with Molecular function considered to be level 0)
    • a GO term c-value generated by ConFunc
    • the count - absolute number of time GO term present in set of homologues
    • frequency - percentage presence of GO term in set of annotated homologues

Some of the results for the example are shown below:


GO term sub-alignments 

A sub-alignment is associated with each GO term. Simply click on a term is display its sub-alignment. So you would click on GO:0003924 in the above example to view its sub-alignment.

A portion of this sub-alignment is shown below.

  • Functional residues identified by ConFunc are coloured.
  • The key at the top describes the colouring scheme. The darker the colour the more conserved it is.


view the full results page for this example:



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Mark Wass