Sara Dobbins

I am a final year PhD student in the Structural Bioinformatics Group supervised by Professor Michael JE Sternberg at Imperial College London. I previously studied Physics (MSci) as part of the Natural Sciences Tripos at the University of Cambridge and also hold a Masters in Bioinformatics from Imperial College.

Email:	sara.dobbins04 AT imperial.ac.uk
Tel:	+44 (0) 20 7594 5737
Mailing Address:	Structural Bioinformatics Group
	Centre for Bioinformatics Division of Molecular Biosciences Faculty of Life Sciences Imperial College London SW7 2AZ UK

ACADEMIC INTERESTS

Knowledge of interactions between proteins provides broad implications including understanding the mechanism of interaction, protein design, and assigning putative functions to uncharacterised proteins. Understanding protein flexibility is a key challenge in the field of protein-protein docking. My PhD aims to assess the ability of normal modes, via the elastic network model, to model protein flexibility.

Normal modes of Actin produced by ElNemo

PUBLICATION LIST

• Sara E Dobbins, Victor I Lesk and Michael JE Sternberg (2008) Insights into protein flexibility: The relationship between normal modes and conformational change upon protein-protein docking, PNAS, 10390-10395

•Jonathan R Yates, Sara E Dobbins, Chris J Pickard, Francesco Mauri, Phuong Y Ghi and Robin K Harris (2005) A combined first principles computational and solid-state NMR study of a molecular crystal: flurbiprofen, Phys. Chem. Chem. Phys. 7, 1402-1407

LINKS

Protein Set Information Page (in development)
3d Garden - Docking server produced by Victor Lesk

With thanks to the

DOWNLOADS

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