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Job DescriptionALS_intensive
Confidence100.00%DateTue Feb 21 10:39:47 GMT 2012
Rank6Aligned Residues498
% Identity22%Templatec1ziwA_
PDB info PDB header:immune systemChain: A: PDB Molecule:toll-like receptor 3; PDBTitle: human toll-like receptor 3 extracellular domain structure
Resolution2.10 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   57..60.........70.........80.........90.........100.........110.........120.........130......
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Query Sequence  SVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRS
Query Conservation   
 
    

 

  
   
  
 

 
 
  
    
  
  
  
 

 
 
  
 
  
  
  
  
 

 
 
  
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Template Conservation     
    
  

  
   
  
 

 
 
  
    
  
  
  
 

 
 
  
       
  
  
 

 
 
  
Template Sequence  VADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQ
Template Known Secondary structure 

SS

SS

S
S
TT
S

SS





GGGGGGGTT
S

SS





TT
TT



SS



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   34.....40.........50.........60.........70.........80.........90.........100.........110...
 
   137..140.........150.........160.........170.........180.........190.........200.........210......
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Query Sequence  LALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSG
Query Conservation 
    
  
  
  
 

 
 
             
  
                                         
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Template Conservation       
  
  
  
 

 
 
          
  
  
 

 
               
       
            
Template Sequence  LSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDI
Template Known Secondary structure 

TTTTTT
TT
S

SS





S
TTTT
TT



SS

S




SSS

TT



SS



B
GG
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   114.....120.........130.........140.........150.........160.........170.........180.........190...
 
   217..220.........230.........240.........250.........260.........270.........280.........290......
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Query Sequence  LAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLR
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Template Conservation                                                                                  
Template Sequence  FANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKW
Template Known Secondary structure  GTT
S
TT




B
TTGGGGSS

TT


TTS



TTS



TTTTGGGGG
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   194.....200.........210.........220.........230.........240.........250.........260.........270...
 
   297..300.
Predicted Secondary structure 




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Query Sequence  LSHNA. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation       ...........................................................................
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Template Conservation                                                                                  
Template Sequence  TNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQLPKIDDFSFQWLKCLEH
Template Known Secondary structure  S



TTS



TTTTTT
TT



S

BS
TTTTTT
TT


TT
B





TTTTTT
TT

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   274.....280.........290.........300.........310.........320.........330.........340.........350...
 
   302.......310.........320.........330.........340...
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . IASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVL
Query Conservation  ......................................                                          
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Template Conservation                                                                                  
Template Sequence  LNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLG
Template Known Secondary structure 

S

B



TTTTTT
TT


TT
BS



TTTTGGGTTS



TTS



TTTTTT
TT



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   360.........370.........380.........390.........400.........410.........420.........430.........
 
   344.....350.........360.........370.........380.........390.........400.........410.........420...
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Query Sequence  TLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLV
Query Conservation                                                                                  
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Template Conservation                                                                                  
Template Sequence  LNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIA
Template Known Secondary structure  SS



SGGGTT
TT



S
S

TTTTTT
TT


TTS

B
TT
SS
TTTT
TT



SS


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   440.........450.........460.........470.........480.........490.........500.........510.........
 
   424.....430.........440.........450... ......460.........470.........480.........490.....
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Query Sequence  GIEEQSLWGLAELLELDLTSNQLTHLPHRL. . . . . . . . FQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLE
Query Conservation                                ........      
  
 
                  
  
 

 
 
 
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Template Conservation           
  
  
 
  
 
  
               
  
  
 

 
 
       
  
  
  
 

 
 
 
Template Sequence  NINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLN
Template Known Secondary structure 


TTTTTT
TT



SS

GGGGSTTSTTS


TTTT
TT



SS





TTTTTT
TT



SS


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   520.........530.........540.........550.........560.........570.........580.........590.........
 
   496...500.........510.........520.... .....530.........540... ......550....
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Query Sequence  ALPNSLLAPLGRLRYLSLRNNSLRTFTPQ. . . . . PPGLERLWLEGNPWDCGCP. LKALRDFALQN
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Template Conservation           
  
  
 

 
 
           
  
  
 
  

  
 
  
     
    
Template Sequence  TLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINET
Template Known Secondary structure 


TTTTTT
TT


TTS


B

TT
S
TT



B




SS

SS

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   600.........610.........620.........630.........640.........650.........660....
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
© Structural Bioinformatics Group, Imperial College, London
Lawrence Kelley, Benjamin Jefferys 
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