Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	E	Q	I	T	F	A	T	S	D	F	A	S	N	P	E	P	R	C	P	C	I	L	L	L	D	V	S	G	S	M	N	G	R	P	I	N	E	L	N	A	G	L	V	T	F	R	D	E	L	L	A	D	P	L	A	L	K	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?					?	?																																								?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	E	L	G	I	V	T	F	G	P	V	H	V	E	Q	P	F	T	S	A	A	N	F	F	P	P	I	L	F	A	Q	G	D	T	P	M	G	A	A	I	T	K	A	L	D	M	V	E	E	R	K	R	E	Y	R	A	N	G	I	S
Secondary structure
SS confidence
Disorder																											?	?		?	?	?	?	?		?															?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Y	Y	R	P	W	I	F	L	I	T	D	G	A	P	T	D	E	W	Q	A	A	A	N	K	V	F	R	G	E	E	D	K	R	F	A	F	F	S	I	G	V	Q	G	A	D	M	K	T	L	A	Q	I	S	V	R	Q	P	L	P	L
Secondary structure
SS confidence
Disorder																																																								?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.
Sequence		Q	G	L	Q	F	R	E	L	F	S	W	L	S	S	S	L	R	S	V	S	R	S	T	P	G	T	E	V	V	L	E	A	P	K	G	W	T	S	V
Secondary structure
SS confidence
Disorder																				?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2i6s chain A Region: 10 - 192 Aligned: 182 Modelled: 182 Confidence: 99.9% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:complement c2a fragment; PDBTitle: complement component c2a Phyre2 PDB 2ok5 chain A Region: 13 - 218 Aligned: 197 Modelled: 203 Confidence: 99.9% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:complement factor b; PDBTitle: human complement factor b Phyre2 PDB 1rs0 chain A Region: 20 - 207 Aligned: 181 Modelled: 188 Confidence: 99.9% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:complement factor b; PDBTitle: crystal structure analysis of the bb segment of factor b2 complexed with di-isopropyl-phosphate (dip) Phyre2 PDB 2ok5 chain A domain 1 Region: 16 - 201 Aligned: 182 Modelled: 185 Confidence: 99.9% Identity: 13% Fold: vWA-like Superfamily: vWA-like Family: Integrin A (or I) domain Phyre2 PDB 1shu chain X Region: 17 - 200 Aligned: 176 Modelled: 184 Confidence: 99.9% Identity: 14% Fold: vWA-like Superfamily: vWA-like Family: Integrin A (or I) domain Phyre2 PDB 3n2n chain C Region: 17 - 200 Aligned: 178 Modelled: 184 Confidence: 99.9% Identity: 16% PDB header:toxin receptor Chain: C: PDB Molecule:anthrax toxin receptor 1; PDBTitle: the crystal structure of tumor endothelial marker 8 (tem8)2 extracellular domain Phyre2 PDB 1u0o chain C domain 1 Region: 17 - 205 Aligned: 188 Modelled: 188 Confidence: 99.8% Identity: 13% Fold: vWA-like Superfamily: vWA-like Family: Integrin A (or I) domain Phyre2 PDB 1atz chain A Region: 18 - 193 Aligned: 172 Modelled: 172 Confidence: 99.8% Identity: 15% Fold: vWA-like Superfamily: vWA-like Family: Integrin A (or I) domain Phyre2 PDB 1ijb chain A Region: 17 - 206 Aligned: 184 Modelled: 190 Confidence: 99.8% Identity: 12% Fold: vWA-like Superfamily: vWA-like Family: Integrin A (or I) domain Phyre2 PDB 2xgg chain B Region: 17 - 162 Aligned: 140 Modelled: 146 Confidence: 99.8% Identity: 14% PDB header:hydrolase Chain: B: PDB Molecule:microneme protein 2; PDBTitle: structure of toxoplasma gondii micronemal protein 2 a_i2 domain Phyre2 PDB 1n3y chain A Region: 18 - 201 Aligned: 179 Modelled: 184 Confidence: 99.8% Identity: 15% Fold: vWA-like Superfamily: vWA-like Family: Integrin A (or I) domain Phyre2 PDB 1q0p chain A Region: 20 - 185 Aligned: 165 Modelled: 166 Confidence: 99.8% Identity: 14% Fold: vWA-like Superfamily: vWA-like Family: Integrin A (or I) domain Phyre2 PDB 3gxb chain B Region: 19 - 202 Aligned: 174 Modelled: 179 Confidence: 99.8% Identity: 12% PDB header:cell adhesion Chain: B: PDB Molecule:von willebrand factor; PDBTitle: crystal structure of vwf a2 domain Phyre2 PDB 1v7p chain C Region: 20 - 199 Aligned: 172 Modelled: 180 Confidence: 99.8% Identity: 15% Fold: vWA-like Superfamily: vWA-like Family: Integrin A (or I) domain Phyre2 PDB 1ck4 chain A Region: 19 - 199 Aligned: 177 Modelled: 181 Confidence: 99.8% Identity: 13% Fold: vWA-like Superfamily: vWA-like Family: Integrin A (or I) domain Phyre2 PDB 3ibs chain A Region: 18 - 202 Aligned: 173 Modelled: 185 Confidence: 99.8% Identity: 17% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical protein batb; PDBTitle: crystal structure of conserved hypothetical protein batb from2 bacteroides thetaiotaomicron Phyre2 PDB 1mf7 chain A Region: 16 - 201 Aligned: 181 Modelled: 185 Confidence: 99.8% Identity: 17% Fold: vWA-like Superfamily: vWA-like Family: Integrin A (or I) domain Phyre2 PDB 1pt6 chain A Region: 19 - 199 Aligned: 177 Modelled: 181 Confidence: 99.7% Identity: 14% Fold: vWA-like Superfamily: vWA-like Family: Integrin A (or I) domain Phyre2 PDB 2b2x chain B Region: 20 - 199 Aligned: 168 Modelled: 172 Confidence: 99.7% Identity: 15% PDB header:immune system Chain: B: PDB Molecule:integrin alpha-1; PDBTitle: vla1 rdeltah i-domain complexed with a quadruple mutant of the aqc22 fab Phyre2 PDB 2x31 chain F Region: 15 - 194 Aligned: 171 Modelled: 180 Confidence: 99.7% Identity: 15% PDB header:ligase Chain: F: PDB Molecule:magnesium-chelatase 60 kda subunit; PDBTitle: modelling of the complex between subunits bchi and bchd of magnesium2 chelatase based on single-particle cryo-em reconstruction at 7.5 ang Phyre2 1 c2i6sA_ 2 c2ok5A_ 3 c1rs0A_ 4 d2ok5a1 5 d1shux_ 6 c3n2nC_ 7 d1u0oc1 8 d1atza_ 9 d1ijba_ 10 c2xggB_ 11 d1n3ya_ 12 d1q0pa_ 13 c3gxbB_ 14 d1v7pc_ 15 d1ck4a_ 16 c3ibsA_ 17 d1mf7a_ 18 d1pt6a_ 19 c2b2xB_ 20 c2x31F_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2i6sA_ 99.9 15 PDB header:hydrolase Chain: A: PDB Molecule:complement c2a fragment; PDBTitle: complement component c2a 2 c2ok5A_ 99.9 13 PDB header:hydrolase Chain: A: PDB Molecule:complement factor b; PDBTitle: human complement factor b 3 c1rs0A_ 99.9 15 PDB header:hydrolase Chain: A: PDB Molecule:complement factor b; PDBTitle: crystal structure analysis of the bb segment of factor b2 complexed with di-isopropyl-phosphate (dip) 4 d2ok5a1 99.9 13 Fold:vWA-like Superfamily:vWA-like Family:Integrin A (or I) domain 5 d1shux_ 99.9 14 Fold:vWA-like Superfamily:vWA-like Family:Integrin A (or I) domain 6 c3n2nC_ 99.9 16 PDB header:toxin receptor Chain: C: PDB Molecule:anthrax toxin receptor 1; PDBTitle: the crystal structure of tumor endothelial marker 8 (tem8)2 extracellular domain 7 d1u0oc1 99.8 13 Fold:vWA-like Superfamily:vWA-like Family:Integrin A (or I) domain 8 d1atza_ 99.8 15 Fold:vWA-like Superfamily:vWA-like Family:Integrin A (or I) domain 9 d1ijba_ 99.8 12 Fold:vWA-like Superfamily:vWA-like Family:Integrin A (or I) domain 10 c2xggB_ 99.8 14 PDB header:hydrolase Chain: B: PDB Molecule:microneme protein 2; PDBTitle: structure of toxoplasma gondii micronemal protein 2 a_i2 domain 11 d1n3ya_ 99.8 15 Fold:vWA-like Superfamily:vWA-like Family:Integrin A (or I) domain 12 d1q0pa_ 99.8 14 Fold:vWA-like Superfamily:vWA-like Family:Integrin A (or I) domain 13 c3gxbB_ 99.8 12 PDB header:cell adhesion Chain: B: PDB Molecule:von willebrand factor; PDBTitle: crystal structure of vwf a2 domain 14 d1v7pc_ 99.8 15 Fold:vWA-like Superfamily:vWA-like Family:Integrin A (or I) domain 15 d1ck4a_ 99.8 13 Fold:vWA-like Superfamily:vWA-like Family:Integrin A (or I) domain 16 c3ibsA_ 99.8 17 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical protein batb; PDBTitle: crystal structure of conserved hypothetical protein batb from2 bacteroides thetaiotaomicron 17 d1mf7a_ 99.8 17 Fold:vWA-like Superfamily:vWA-like Family:Integrin A (or I) domain 18 d1pt6a_ 99.7 14 Fold:vWA-like Superfamily:vWA-like Family:Integrin A (or I) domain 19 c2b2xB_ 99.7 15 PDB header:immune system Chain: B: PDB Molecule:integrin alpha-1; PDBTitle: vla1 rdeltah i-domain complexed with a quadruple mutant of the aqc22 fab 20 c2x31F_ 99.7 15 PDB header:ligase Chain: F: PDB Molecule:magnesium-chelatase 60 kda subunit; PDBTitle: modelling of the complex between subunits bchi and bchd of magnesium2 chelatase based on single-particle cryo-em reconstruction at 7.5 ang 21 c2x5nA_ not modelled 99.7 13 PDB header:nuclear protein Chain: A: PDB Molecule:26s proteasome regulatory subunit rpn10; PDBTitle: crystal structure of the sprpn10 vwa domain 22 d1mjna_ not modelled 99.7 14 Fold:vWA-like Superfamily:vWA-like Family:Integrin A (or I) domain 23 c2iueA_ not modelled 99.6 11 PDB header:membrane protein Chain: A: PDB Molecule:pactolus i-domain; PDBTitle: pactolus i-domain: functional switching of the rossmann2 fold 24 d1jeya2 not modelled 99.6 12 Fold:vWA-like Superfamily:vWA-like Family:Ku70 subunit N-terminal domain 25 d1jeyb2 not modelled 99.5 12 Fold:vWA-like Superfamily:vWA-like Family:Ku80 subunit N-terminal domain 26 d1tyeb2 not modelled 99.4 8 Fold:vWA-like Superfamily:vWA-like Family:Integrin A (or I) domain 27 c3fcuB_ not modelled 99.2 10 PDB header:cell adhesion/blood clotting Chain: B: PDB Molecule:integrin beta-3; PDBTitle: structure of headpiece of integrin aiibb3 in open conformation 28 d1pd0a3 not modelled 99.2 10 Fold:vWA-like Superfamily:vWA-like Family:Trunk domain of Sec23/24 29 d1yvra2 not modelled 99.1 15 Fold:vWA-like Superfamily:vWA-like Family:RoRNP C-terminal domain-like 30 c3v4pB_ not modelled 99.1 13 PDB header:cell adhesion Chain: B: PDB Molecule:integrin beta-7; PDBTitle: crystal structure of a4b7 headpiece complexed with fab act-1 31 c3ragA_ not modelled 99.1 22 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of uncharacterized protein aaci_0196 from2 alicyclobacillus acidocaldarius subsp. acidocaldarius dsm 446 32 c1jeyB_ not modelled 99.1 12 PDB header:dna binding protein/dna Chain: B: PDB Molecule:ku80; PDBTitle: crystal structure of the ku heterodimer bound to dna 33 c1u8cB_ not modelled 99.0 9 PDB header:cell adhesion Chain: B: PDB Molecule:integrin beta-3; PDBTitle: a novel adaptation of the integrin psi domain revealed from its2 crystal structure 34 c2nvoA_ not modelled 98.8 15 PDB header:rna binding protein Chain: A: PDB Molecule:ro sixty-related protein, rsr; PDBTitle: crystal structure of deinococcus radiodurans ro (rsr) protein 35 c3k6sB_ not modelled 98.5 15 PDB header:cell adhesion Chain: B: PDB Molecule:integrin beta-2; PDBTitle: structure of integrin alphaxbeta2 ectodomain 36 c1pd0A_ not modelled 98.0 13 PDB header:transport protein Chain: A: PDB Molecule:protein transport protein sec24; PDBTitle: crystal structure of the copii coat subunit, sec24,2 complexed with a peptide from the snare protein sed53 (yeast syntaxin-5) 37 c1m2vB_ not modelled 97.7 12 PDB header:protein transport Chain: B: PDB Molecule:protein transport protein sec24; PDBTitle: crystal structure of the yeast sec23/24 heterodimer 38 c3egxB_ not modelled 97.6 20 PDB header:protein transport Chain: B: PDB Molecule:protein transport protein sec24a; PDBTitle: crystal structure of the mammalian copii-coat protein2 sec23a/24a complexed with the snare protein sec22b and3 bound to the transport signal sequence of the snare protein4 bet1 39 d2qtva3 not modelled 97.6 17 Fold:vWA-like Superfamily:vWA-like Family:Trunk domain of Sec23/24 40 c1yvrA_ not modelled 97.4 14 PDB header:rna binding protein Chain: A: PDB Molecule:60-kda ss-a/ro ribonucleoprotein; PDBTitle: ro autoantigen 41 c1jeqA_ not modelled 97.4 13 PDB header:dna binding protein Chain: A: PDB Molecule:ku70; PDBTitle: crystal structure of the ku heterodimer 42 c3eg9A_ not modelled 97.1 13 PDB header:protein transport Chain: A: PDB Molecule:protein transport protein sec23a; PDBTitle: crystal structure of the mammalian copii-coat protein2 sec23/24 bound to the transport signal sequence of membrin 43 c3eh2B_ not modelled 96.8 16 PDB header:protein transport Chain: B: PDB Molecule:protein transport protein sec24c; PDBTitle: crystal structure of the human copii-coat protein sec24c 44 c1m2oA_ not modelled 96.6 16 PDB header:protein transport/signaling protein Chain: A: PDB Molecule:protein transport protein sec23; PDBTitle: crystal structure of the sec23-sar1 complex 45 c3eg9B_ not modelled 95.0 15 PDB header:protein transport Chain: B: PDB Molecule:sec24 related gene family, member d; PDBTitle: crystal structure of the mammalian copii-coat protein2 sec23/24 bound to the transport signal sequence of membrin 46 d1cjya2 not modelled 37.4 15 Fold:FabD/lysophospholipase-like Superfamily:FabD/lysophospholipase-like Family:Lysophospholipase 47 c1sy7B_ not modelled 23.8 22 PDB header:oxidoreductase Chain: B: PDB Molecule:catalase 1; PDBTitle: crystal structure of the catalase-1 from neurospora crassa, native2 structure at 1.75a resolution. 48 c1j9zB_ not modelled 20.2 21 PDB header:oxidoreductase Chain: B: PDB Molecule:nadph-cytochrome p450 reductase; PDBTitle: cypor-w677g 49 d1qvwa_ not modelled 19.7 20 Fold:Flavodoxin-like Superfamily:Class I glutamine amidotransferase-like Family:DJ-1/PfpI 50 c1cjyB_ not modelled 17.6 15 PDB header:hydrolase Chain: B: PDB Molecule:protein (cytosolic phospholipase a2); PDBTitle: human cytosolic phospholipase a2 51 c2bpoA_ not modelled 14.6 13 PDB header:reductase Chain: A: PDB Molecule:nadph-cytochrom p450 reductase; PDBTitle: crystal structure of the yeast cpr triple mutant: d74g,2 y75f, k78a. 52 c1tllA_ not modelled 13.5 15 PDB header:oxidoreductase Chain: A: PDB Molecule:nitric-oxide synthase, brain; PDBTitle: crystal structure of rat neuronal nitric-oxide synthase2 reductase module at 2.3 a resolution. 53 c3dxvA_ not modelled 10.8 14 PDB header:isomerase Chain: A: PDB Molecule:alpha-amino-epsilon-caprolactam racemase; PDBTitle: the crystal structure of alpha-amino-epsilon-caprolactam racemase from2 achromobacter obae 54 d2nx2a1 not modelled 10.1 11 Fold:MCP/YpsA-like Superfamily:MCP/YpsA-like Family:YpsA-like 55 d2vgna3 not modelled 9.1 15 Fold:Bacillus chorismate mutase-like Superfamily:L30e-like Family:ERF1/Dom34 C-terminal domain-like 56 d1r9ja2 not modelled 9.0 13 Fold:Thiamin diphosphate-binding fold (THDP-binding) Superfamily:Thiamin diphosphate-binding fold (THDP-binding) Family:TK-like PP module 57 c3cneD_ not modelled 8.7 8 PDB header:hydrolase Chain: D: PDB Molecule:putative protease i; PDBTitle: crystal structure of the putative protease i from bacteroides2 thetaiotaomicron 58 c3fseB_ not modelled 8.4 17 PDB header:hydrolase Chain: B: PDB Molecule:two-domain protein containing dj-1/thij/pfpi-like and PDBTitle: crystal structure of a two-domain protein containing dj-1/thij/pfpi-2 like and ferritin-like domains (ava_4496) from anabaena variabilis3 atcc 29413 at 1.90 a resolution 59 d1x6va3 not modelled 8.4 7 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Adenosine-5'phosphosulfate kinase (APS kinase) 60 c1p81A_ not modelled 8.3 14 PDB header:oxidoreductase Chain: A: PDB Molecule:catalase hpii; PDBTitle: crystal structure of the d181e variant of catalase hpii2 from e. coli 61 d1tlla2 not modelled 8.0 13 Fold:Flavodoxin-like Superfamily:Flavoproteins Family:Cytochrome p450 reductase N-terminal domain-like 62 d1b1ca_ not modelled 7.5 22 Fold:Flavodoxin-like Superfamily:Flavoproteins Family:Cytochrome p450 reductase N-terminal domain-like 63 c3l82B_ not modelled 6.8 7 PDB header:cell cycle Chain: B: PDB Molecule:f-box only protein 4; PDBTitle: x-ray crystal structure of trf1 and fbx4 complex 64 d1we3a2 not modelled 6.7 15 Fold:The "swivelling" beta/beta/alpha domain Superfamily:GroEL apical domain-like Family:GroEL-like chaperone, apical domain 65 d1p80a1 not modelled 6.7 14 Fold:Flavodoxin-like Superfamily:Class I glutamine amidotransferase-like Family:Catalase, C-terminal domain 66 d2nlya1 not modelled 6.5 13 Fold:7-stranded beta/alpha barrel Superfamily:Glycoside hydrolase/deacetylase Family:Divergent polysaccharide deacetylase 67 c2o1sC_ not modelled 6.4 13 PDB header:transferase Chain: C: PDB Molecule:1-deoxy-d-xylulose-5-phosphate synthase; PDBTitle: 1-deoxy-d-xylulose 5-phosphate synthase (dxs) from2 escherichia coli 68 d2c42a3 not modelled 6.1 15 Fold:TK C-terminal domain-like Superfamily:TK C-terminal domain-like Family:Pyruvate-ferredoxin oxidoreductase, PFOR, domain II 69 c3kklA_ not modelled 5.8 22 PDB header:hydrolase Chain: A: PDB Molecule:probable chaperone protein hsp33; PDBTitle: crystal structure of functionally unknown hsp33 from2 saccharomyces cerevisiae 70 d1bvyf_ not modelled 5.4 14 Fold:Flavodoxin-like Superfamily:Flavoproteins Family:Flavodoxin-related 71 c1bvyF_ not modelled 5.4 14 PDB header:oxidoreductase Chain: F: PDB Molecule:protein (cytochrome p450 bm-3); PDBTitle: complex of the heme and fmn-binding domains of the2 cytochrome p450(bm-3) 72 d1nn5a_ not modelled 5.3 14 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Nucleotide and nucleoside kinases 73 d1fs0g_ not modelled 5.3 12 Fold:Pyruvate kinase C-terminal domain-like Superfamily:ATP synthase (F1-ATPase), gamma subunit Family:ATP synthase (F1-ATPase), gamma subunit 74 c3n39D_ not modelled 5.2 10 PDB header:oxidoreductase Chain: D: PDB Molecule:protein nrdi; PDBTitle: ribonucleotide reductase dimanganese(ii)-nrdf from escherichia coli in2 complex with nrdi 75 d1itza1 not modelled 5.2 14 Fold:Thiamin diphosphate-binding fold (THDP-binding) Superfamily:Thiamin diphosphate-binding fold (THDP-binding) Family:TK-like PP module

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0