Email l.a.kelley@imperial.ac.uk Description P24178 Date Thu Jan 5 11:40:55 GMT 2012 Unique Job ID fe30482df065f3b7

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2kokA_ 100.0 53 PDB header:oxidoreductase Chain: A: PDB Molecule:arsenate reductase; PDBTitle: solution structure of an arsenate reductase (arsc) related protein2 from brucella melitensis. seattle structural genomics center for3 infectious disease target braba.00007.a. 2 d1rw1a_ 100.0 46 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:ArsC-like 3 c3fz4A_ 100.0 26 PDB header:oxidoreductase Chain: A: PDB Molecule:putative arsenate reductase; PDBTitle: the crystal structure of a possible arsenate reductase from2 streptococcus mutans ua159 4 c3gkxB_ 100.0 26 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative arsc family related protein; PDBTitle: crystal structure of putative arsc family related protein from2 bacteroides fragilis 5 c3l78A_ 100.0 26 PDB header:transcription Chain: A: PDB Molecule:regulatory protein spx; PDBTitle: the crystal structure of smu.1142c from streptococcus mutans ua159 6 d1z3ea1 100.0 25 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:ArsC-like 7 c3f0iA_ 100.0 19 PDB header:oxidoreductase Chain: A: PDB Molecule:arsenate reductase; PDBTitle: arsenate reductase from vibrio cholerae. 8 c3rdwB_ 100.0 18 PDB header:oxidoreductase Chain: B: PDB Molecule:putative arsenate reductase; PDBTitle: putative arsenate reductase from yersinia pestis 9 d1j9ba_ 100.0 16 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:ArsC-like 10 d1h75a_ 98.8 14 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Thioltransferase 11 c3nznA_ 98.7 19 PDB header:oxidoreductase Chain: A: PDB Molecule:glutaredoxin; PDBTitle: the crystal structure of the glutaredoxin from methanosarcina mazei2 go1 12 d1r7ha_ 98.7 34 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Thioltransferase 13 c3ic4A_ 98.7 14 PDB header:oxidoreductase Chain: A: PDB Molecule:glutaredoxin (grx-1); PDBTitle: the crystal structure of the glutaredoxin(grx-1) from archaeoglobus2 fulgidus 14 c3lgcA_ 98.3 21 PDB header:unknown function Chain: A: PDB Molecule:glutaredoxin 1; PDBTitle: crystal structure of glutaredoxin 1 from francisella2 tularensis 15 d1abaa_ 98.1 25 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Thioltransferase 16 c1nm3B_ 98.0 8 PDB header:electron transport Chain: B: PDB Molecule:protein hi0572; PDBTitle: crystal structure of heamophilus influenza hybrid-prx5 17 d1fova_ 97.9 14 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Thioltransferase 18 c2khpA_ 97.7 14 PDB header:electron transport Chain: A: PDB Molecule:glutaredoxin; PDBTitle: solution structure of glutaredoxin from brucella melitensis 19 d1nm3a1 97.7 12 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Thioltransferase 20 c2ht9A_ 97.7 16 PDB header:oxidoreductase Chain: A: PDB Molecule:glutaredoxin-2; PDBTitle: the structure of dimeric human glutaredoxin 2 21 c3fzaA_ not modelled 97.7 13 PDB header:oxidoreductase Chain: A: PDB Molecule:glutaredoxin; PDBTitle: crystal structure of poplar glutaredoxin s12 in complex with2 glutathione and beta-mercaptoethanol 22 d1t1va_ not modelled 97.4 16 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:SH3BGR (SH3-binding, glutamic acid-rich protein-like) 23 c2e7pC_ not modelled 97.4 14 PDB header:electron transport Chain: C: PDB Molecule:glutaredoxin; PDBTitle: crystal structure of the holo form of glutaredoxin c1 from populus2 tremula x tremuloides 24 c2klxA_ not modelled 97.4 32 PDB header:oxidoreductase Chain: A: PDB Molecule:glutaredoxin; PDBTitle: solution structure of glutaredoxin from bartonella henselae str.2 houston 25 c3h8qB_ not modelled 97.3 4 PDB header:oxidoreductase Chain: B: PDB Molecule:thioredoxin reductase 3; PDBTitle: crystal structure of glutaredoxin domain of human thioredoxin2 reductase 3 26 c3m3mA_ not modelled 97.1 16 PDB header:transferase Chain: A: PDB Molecule:glutathione s-transferase; PDBTitle: crystal structure of glutathione s-transferase from pseudomonas2 fluorescens [pf-5] 27 c1yy7A_ not modelled 97.0 15 PDB header:transcription Chain: A: PDB Molecule:stringent starvation protein a; PDBTitle: crystal structure of stringent starvation protein a (sspa),2 an rna polymerase-associated transcription factor 28 d1egoa_ not modelled 97.0 23 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Thioltransferase 29 c3m8nA_ not modelled 96.9 22 PDB header:transferase Chain: A: PDB Molecule:possible glutathione s-transferase; PDBTitle: crystal structure of a possible gutathione s-tranferase from2 rhodopseudomonas palustris 30 c3touB_ not modelled 96.9 28 PDB header:transferase Chain: B: PDB Molecule:glutathione s-transferase protein; PDBTitle: crystal structure of glutathione transferase (target efi-501058) from2 ralstonia solanacearum gmi1000 with gsh bound 31 d1z9ha2 not modelled 96.9 26 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 32 d1ktea_ not modelled 96.8 13 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Thioltransferase 33 d1wika_ not modelled 96.8 23 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Thioltransferase 34 d1eema2 not modelled 96.6 15 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 35 c3gx0A_ not modelled 96.5 29 PDB header:transferase Chain: A: PDB Molecule:gst-like protein yfcg; PDBTitle: crystal structure of gsh-dependent disulfide bond2 oxidoreductase 36 d1jhba_ not modelled 96.5 13 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Thioltransferase 37 c1ykaA_ not modelled 96.5 18 PDB header:electron transport Chain: A: PDB Molecule:monothiol glutaredoxin ydhd; PDBTitle: solution structure of grx4, a monothiol glutaredoxin from2 e. coli. 38 c2hzfA_ not modelled 96.4 15 PDB header:electron transport, oxidoreductase Chain: A: PDB Molecule:glutaredoxin-1; PDBTitle: crystal structures of a poxviral glutaredoxin in the oxidized and2 reduced states show redox-correlated structural changes 39 c2jl4A_ not modelled 96.2 19 PDB header:isomerase Chain: A: PDB Molecule:maleylpyruvate isomerase; PDBTitle: holo structure of maleyl pyruvate isomerase, a bacterial2 glutathione-s-transferase in zeta class 40 c1oyjC_ not modelled 96.1 10 PDB header:transferase Chain: C: PDB Molecule:glutathione s-transferase; PDBTitle: crystal structure solution of rice gst1 (osgstu1) in complex with2 glutathione. 41 d1oyja2 not modelled 96.1 10 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 42 d1gnwa2 not modelled 96.1 13 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 43 c2ct6A_ not modelled 96.0 19 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:sh3 domain-binding glutamic acid-rich-like PDBTitle: solution structure of the sh3 domain-binding glutamic acid-2 rich-like protein 2 44 d1wjka_ not modelled 96.0 15 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Thioltransferase 45 c1z9hB_ not modelled 96.0 29 PDB header:isomerase Chain: B: PDB Molecule:membrane-associated prostaglandin e synthase-2; PDBTitle: microsomal prostaglandin e synthase type-2 46 c3cbuB_ not modelled 95.9 16 PDB header:transferase Chain: B: PDB Molecule:probable gst-related protein; PDBTitle: crystal structure of a putative glutathione s-transferase (reut_a1011)2 from ralstonia eutropha jmp134 at 2.05 a resolution 47 d1jlva2 not modelled 95.9 6 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 48 d1v2aa2 not modelled 95.8 9 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 49 d1gwca2 not modelled 95.8 14 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 50 c1g7oA_ not modelled 95.8 26 PDB header:oxidoreductase Chain: A: PDB Molecule:glutaredoxin 2; PDBTitle: nmr solution structure of reduced e. coli glutaredoxin 2 51 c3uarA_ not modelled 95.8 13 PDB header:transferase Chain: A: PDB Molecule:glutathione s-transferase; PDBTitle: crystal structure of glutathione transferase (target efi-501774) from2 methylococcus capsulatus str. bath with gsh bound 52 d1k0da2 not modelled 95.7 16 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 53 c1gwcC_ not modelled 95.7 14 PDB header:transferase Chain: C: PDB Molecule:glutathione s-transferase tsi-1; PDBTitle: the structure of a tau class glutathione s-transferase from2 wheat, active in herbicide detoxification 54 d1ttza_ not modelled 95.6 16 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Thioltransferase 55 c3lykA_ not modelled 95.6 16 PDB header:transport protein Chain: A: PDB Molecule:stringent starvation protein a homolog; PDBTitle: structure of stringent starvation protein a homolog from2 haemophilus influenzae 56 d1jlwa2 not modelled 95.6 6 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 57 c3l4nA_ not modelled 95.6 20 PDB header:oxidoreductase Chain: A: PDB Molecule:monothiol glutaredoxin-6; PDBTitle: crystal structure of yeast monothiol glutaredoxin grx6 58 d1g7oa2 not modelled 95.5 26 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 59 c3nivD_ not modelled 95.5 17 PDB header:isomerase Chain: D: PDB Molecule:glutathione s-transferase; PDBTitle: the crystal structure of glutathione s-transferase from legionella2 pneumophila 60 c1eemA_ not modelled 95.5 19 PDB header:transferase Chain: A: PDB Molecule:glutathione-s-transferase; PDBTitle: glutathione transferase from homo sapiens 61 d1pn9a2 not modelled 95.5 6 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 62 c1ljrB_ not modelled 95.5 10 PDB header:transferase Chain: B: PDB Molecule:glutathione s-transferase; PDBTitle: glutathione transferase (hgst t2-2) from human 63 c3ipzA_ not modelled 95.4 14 PDB header:electron transport, oxidoreductase Chain: A: PDB Molecule:monothiol glutaredoxin-s14, chloroplastic; PDBTitle: crystal structure of arabidopsis monothiol glutaredoxin atgrxcp 64 d1e6ba2 not modelled 95.4 19 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 65 c1k0dB_ not modelled 95.4 16 PDB header:gene regulation Chain: B: PDB Molecule:ure2 protein; PDBTitle: ure2p in complex with glutathione 66 c2c3nB_ not modelled 95.4 13 PDB header:transferase Chain: B: PDB Molecule:glutathione s-transferase theta 1; PDBTitle: human glutathione-s-transferase t1-1, apo form 67 d1aw9a2 not modelled 95.4 16 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 68 d1axda2 not modelled 95.4 22 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 69 c2wulB_ not modelled 95.4 16 PDB header:oxidoreductase Chain: B: PDB Molecule:glutaredoxin related protein 5; PDBTitle: crystal structure of the human glutaredoxin 5 with bound2 glutathione in an fes cluster 70 d1k0dd2 not modelled 95.3 16 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 71 c2jacA_ not modelled 95.3 11 PDB header:electron transport Chain: A: PDB Molecule:glutaredoxin-1; PDBTitle: glutaredoxin grx1p c30s mutant from yeast 72 d1ljra2 not modelled 95.2 10 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 73 c1v2aD_ not modelled 95.2 10 PDB header:transferase Chain: D: PDB Molecule:glutathione transferase gst1-6; PDBTitle: glutathione s-transferase 1-6 from anopheles dirus species b 74 c1e6bA_ not modelled 95.1 19 PDB header:transferase Chain: A: PDB Molecule:glutathione s-transferase; PDBTitle: crystal structure of a zeta class glutathione s-transferase2 from arabidopsis thaliana 75 c3lypA_ not modelled 95.1 9 PDB header:transcription Chain: A: PDB Molecule:stringent starvation protein a; PDBTitle: structure of stringent starvation protein a homolog from pseudomonas2 fluorescens 76 c3f6fA_ not modelled 95.0 6 PDB header:transferase Chain: A: PDB Molecule:cg18548-pa (ip02196p) (ip02193p); PDBTitle: crystal structure of glutathione transferase dmgstd10 from2 drosophila melanogaster 77 c3bbyA_ not modelled 95.0 11 PDB header:transferase Chain: A: PDB Molecule:uncharacterized gst-like protein yfcf; PDBTitle: crystal structure of glutathione s-transferase (np_416804.1) from2 escherichia coli k12 at 1.85 a resolution 78 c1gnwA_ not modelled 94.9 13 PDB header:transferase Chain: A: PDB Molecule:glutathione s-transferase; PDBTitle: structure of glutathione s-transferase 79 c1jlvA_ not modelled 94.9 6 PDB header:transferase Chain: A: PDB Molecule:glutathione transferase gst1-3; PDBTitle: anopheles dirus species b glutathione s-transferases 1-3 80 c1jlwA_ not modelled 94.8 6 PDB header:transferase Chain: A: PDB Molecule:glutathione transferase gst1-4; PDBTitle: anopheles dirus species b glutathione s-transferases 1-4 81 c3lxzD_ not modelled 94.8 13 PDB header:transferase Chain: D: PDB Molecule:glutathione s-transferase family protein; PDBTitle: structure of probable glutathione s-transferase(pp0183) from2 pseudomonas putida 82 c2vo4A_ not modelled 94.8 19 PDB header:transferase Chain: A: PDB Molecule:2,4-d inducible glutathione s-transferase; PDBTitle: glutathione transferase from glycine max 83 c1u6tA_ not modelled 94.8 16 PDB header:protein binding, signaling protein Chain: A: PDB Molecule:sh3 domain-binding glutamic acid-rich-like PDBTitle: crystal structure of the human sh3 binding glutamic-rich2 protein like 84 c3d5jB_ not modelled 94.7 14 PDB header:oxidoreductase Chain: B: PDB Molecule:glutaredoxin-2, mitochondrial; PDBTitle: structure of yeast grx2-c30s mutant with glutathionyl mixed2 disulfide 85 c3rbtD_ not modelled 94.7 19 PDB header:transferase Chain: D: PDB Molecule:glutathione transferase o1; PDBTitle: crystal structure of glutathione s-transferase omega 3 from the2 silkworm bombyx mori 86 c3ay8A_ not modelled 94.6 16 PDB header:transferase Chain: A: PDB Molecule:glutathione s-transferase; PDBTitle: glutathione s-transferase unclassified 2 from bombyx mori 87 c2imiA_ not modelled 94.6 10 PDB header:transferase Chain: A: PDB Molecule:epsilon-class glutathione s-transferase; PDBTitle: structures of an insect epsilon-class glutathione s-2 transferase from the malaria vector anopheles gambiae:3 evidence for high ddt-detoxifying activity 88 c1byeA_ not modelled 94.5 23 PDB header:transferase Chain: A: PDB Molecule:protein (glutathione s-transferase); PDBTitle: glutathione s-transferase i from mais in complex with2 atrazine glutathione conjugate 89 d1fw1a2 not modelled 94.4 23 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 90 c1aw9A_ not modelled 94.3 16 PDB header:transferase Chain: A: PDB Molecule:glutathione s-transferase iii; PDBTitle: structure of glutathione s-transferase iii in apo form 91 c3c1sA_ not modelled 94.3 8 PDB header:oxidoreductase Chain: A: PDB Molecule:glutaredoxin-1; PDBTitle: crystal structure of grx1 in glutathionylated form 92 c1k0nB_ not modelled 94.2 14 PDB header:metal transport Chain: B: PDB Molecule:chloride intracellular channel protein 1; PDBTitle: chloride intracellular channel 1 (clic1) complexed with glutathione 93 d1r5aa2 not modelled 94.1 6 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 94 c2cz2A_ not modelled 94.1 23 PDB header:isomerase, transferase Chain: A: PDB Molecule:maleylacetoacetate isomerase; PDBTitle: crystal structure of glutathione transferase zeta 1-12 (maleylacetoacetate isomerase) from mus musculus (form-1 crystal) 95 c3lg6B_ not modelled 94.1 23 PDB header:transferase Chain: B: PDB Molecule:putative glutathione transferase; PDBTitle: crystal structure of putative glutathione transferase from2 coccidioides immitis 96 c3ergA_ not modelled 94.0 12 PDB header:transferase Chain: A: PDB Molecule:glutathione s-transferase 2; PDBTitle: crystal structure of gtt2 from saccharomyces cerevisiae in complex2 with glutathione sulfnate 97 c1oktA_ not modelled 93.6 16 PDB header:transferase Chain: A: PDB Molecule:glutathione s-transferase; PDBTitle: x-ray structure of glutathione s-transferase from the2 malarial parasite plasmodium falciparum 98 c1jzdA_ not modelled 93.6 16 PDB header:oxidoreductase Chain: A: PDB Molecule:thiol:disulfide interchange protein dsbc; PDBTitle: dsbc-dsbdalpha complex 99 c3m0fA_ not modelled 93.3 13 PDB header:transferase Chain: A: PDB Molecule:uncharacterized protein gst_n; PDBTitle: crystal structure of glutathione s transferase in complex2 with glutathione from pseudomonas fluorescens 100 c3gv1A_ not modelled 93.1 12 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:disulfide interchange protein; PDBTitle: crystal structure of disulfide interchange protein from neisseria2 gonorrhoeae 101 c3ic8D_ not modelled 93.0 16 PDB header:structural genomics, unknown function Chain: D: PDB Molecule:uncharacterized gst-like proteinprotein; PDBTitle: the crystal structure of a gst-like protein from pseudomonas syringae2 to 2.4a 102 d1n2aa2 not modelled 92.9 10 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 103 c1t3bA_ not modelled 92.8 10 PDB header:isomerase Chain: A: PDB Molecule:thiol:disulfide interchange protein dsbc; PDBTitle: x-ray structure of dsbc from haemophilus influenzae 104 c1r5aA_ not modelled 92.8 6 PDB header:transferase Chain: A: PDB Molecule:glutathione transferase; PDBTitle: glutathione s-transferase 105 c3gx8A_ not modelled 92.8 16 PDB header:electron transport Chain: A: PDB Molecule:monothiol glutaredoxin-5, mitochondrial; PDBTitle: structural and biochemical characterization of yeast2 monothiol glutaredoxin grx5 106 c1c72A_ not modelled 92.7 21 PDB header:transferase Chain: A: PDB Molecule:protein (glutathione s-transferase); PDBTitle: tyr115, gln165 and trp209 contribute to the 1,2-epoxy-3-(p-2 nitrophenoxy)propane conjugating activities of glutathione3 s-transferase cgstm1-1 107 c3fy7B_ not modelled 92.6 9 PDB header:transport protein Chain: B: PDB Molecule:chloride intracellular channel protein 3; PDBTitle: crystal structure of homo sapiens clic3 108 d1iloa_ not modelled 92.6 19 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Thioltransferase 109 d1v58a1 not modelled 92.3 10 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:DsbC/DsbG C-terminal domain-like 110 c2x64A_ not modelled 92.3 7 PDB header:transferase Chain: A: PDB Molecule:glutathione-s-transferase; PDBTitle: glutathione-s-transferase from xylella fastidiosa 111 c3c8eB_ not modelled 91.5 23 PDB header:transferase Chain: B: PDB Molecule:yghu, glutathione s-transferase homologue; PDBTitle: crystal structure analysis of yghu from e. coli 112 c2r4vA_ not modelled 91.5 11 PDB header:transport protein Chain: A: PDB Molecule:chloride intracellular channel protein 2; PDBTitle: structure of human clic2, crystal form a 113 d1f2ea2 not modelled 91.5 10 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 114 c3lq7B_ not modelled 91.2 14 PDB header:transferase Chain: B: PDB Molecule:glutathione s-transferase; PDBTitle: crystal structure of glutathione s-transferase from2 agrobacterium tumefaciens str. c58 115 c2fgxA_ not modelled 91.0 11 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative thioredoxin; PDBTitle: solution nmr structure of protein ne2328 from nitrosomonas2 europaea. northeast structural genomics consortium target3 net3. 116 d1t3ba1 not modelled 90.7 10 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:DsbC/DsbG C-terminal domain-like 117 c1yq1A_ not modelled 90.3 8 PDB header:transferase Chain: A: PDB Molecule:glutathione s-transferase; PDBTitle: structural genomics of caenorhabditis elegans: glutathione2 s-transferase 118 d1okta2 not modelled 90.1 18 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain 119 c2gdrA_ not modelled 90.0 10 PDB header:transferase Chain: A: PDB Molecule:glutathione s-transferase; PDBTitle: crystal structure of a bacterial glutathione transferase 120 d1k0ma2 not modelled 89.8 12 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Glutathione S-transferase (GST), N-terminal domain