Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	Q	S	T	R	I	S	M	G	L	F	F	K	Y	F	L	S	L	T	K	I	D	P	G	Q	N	Y	I	S	L	P	S	I	K	S	S	T	H	I	A	L	L	F	M	V	S	M	G	T	Q	K	L	K	A	Q	S	F	F	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																								?				?	?	?												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	S	L	L	L	T	L	I	L	F	C	I	T	T	L	Y	N	E	N	T	N	V	K	L	I	P	Q	M	N	Y	L	M	V	V	V	A	L	F	F	L	N	A	V	I	F	L	F	M	L	M	K	Y	F	T	N	K	Q	I	L	P
Secondary structure
SS confidence
Disorder																					?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	L	I	L	S	L	A	F	L	S	G	L	I	Y	L	V	E	T	I	V	I	I	H	K	P	I	N	G	S	T	L	I	Q	T	K	S	N	D	V	S	I	F	Y	I	F	R	Q	L	S	F	I	C	L	T	S	L	A	L	F	C
Secondary structure
SS confidence
Disorder																												?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		Y	G	K	D	N	I	L	D	N	N	K	K	K	T	G	I	L	L	L	A	L	I	P	F	L	V	F	P	L	L	A	H	N	L	S	S	Y	N	A	D	Y	S	L	Y	V	V	D	Y	C	P	D	N	H	T	A	T	W	G	I	N
Secondary structure
SS confidence
Disorder			?	?	?	?	?		?	?	?																																										?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Y	T	K	I	L	V	C	L	W	A	F	L	L	F	F	I	I	M	R	T	R	L	A	S	E	L	W	P	L	I	A	L	L	C	L	A	S	L	C	C	N	L	L	L	L	T	L	D	E	Y	N	Y	T	I	W	Y	I	S	R	G
Secondary structure
SS confidence
Disorder																					?	?	?																										?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		I	E	V	S	S	K	L	F	V	V	S	F	L	I	Y	N	I	F	Q	E	L	Q	L	S	S	K	L	A	V	H	D	V	L	T	N	I	Y	N	R	R	Y	F	F	N	S	V	E	S	L	L	S	R	P	V	V	K	D	F	C	V
Secondary structure
SS confidence
Disorder																													?	?																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		M	L	V	D	I	N	Q	F	K	R	I	N	A	Q	W	G	H	R	V	G	D	K	V	L	V	S	I	V	D	I	I	Q	Q	S	I	R	P	D	D	I	L	A	R	L	E	G	E	V	F	G	L	L	F	T	E	L	N	S	A	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		A	K	I	I	A	E	R	M	R	K	N	V	E	L	L	T	G	F	S	N	R	Y	D	V	P	E	Q	M	T	I	S	I	G	T	V	F	S	T	G	D	T	R	N	I	S	L	V	M	T	E	A	D	K	A	L	R	E	A	K	S
Secondary structure
SS confidence
Disorder																			?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.
Sequence		E	G	G	N	K	V	I	I	H	H	I
Secondary structure
SS confidence
Disorder												?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1w25 chain B Region: 298 - 489 Aligned: 192 Modelled: 192 Confidence: 100.0% Identity: 29% PDB header:signaling protein Chain: B: PDB Molecule:stalked-cell differentiation controlling protein; PDBTitle: response regulator pled in complex with c-digmp Phyre2 PDB 3ezu chain A Region: 303 - 488 Aligned: 175 Modelled: 186 Confidence: 100.0% Identity: 25% PDB header:signaling protein Chain: A: PDB Molecule:ggdef domain protein; PDBTitle: crystal structure of multidomain protein of unknown function with2 ggdef-domain (np_951600.1) from geobacter sulfurreducens at 1.95 a3 resolution Phyre2 PDB 3bre chain A Region: 284 - 490 Aligned: 207 Modelled: 207 Confidence: 99.9% Identity: 24% PDB header:signaling protein Chain: A: PDB Molecule:probable two-component response regulator; PDBTitle: crystal structure of p.aeruginosa pa3702 Phyre2 PDB 3i5a chain A Region: 287 - 487 Aligned: 201 Modelled: 201 Confidence: 99.9% Identity: 24% PDB header:signaling protein Chain: A: PDB Molecule:response regulator/ggdef domain protein; PDBTitle: crystal structure of full-length wpsr from pseudomonas syringae Phyre2 PDB 3i5c chain A Region: 302 - 488 Aligned: 187 Modelled: 187 Confidence: 99.9% Identity: 28% PDB header:signaling protein Chain: A: PDB Molecule:fusion of general control protein gcn4 and wspr response PDBTitle: crystal structure of a fusion protein containing the leucine zipper of2 gcn4 and the ggdef domain of wspr from pseudomonas aeruginosa Phyre2 PDB 3i5b chain A Region: 327 - 490 Aligned: 164 Modelled: 164 Confidence: 99.9% Identity: 29% PDB header:signaling protein Chain: A: PDB Molecule:wspr response regulator; PDBTitle: crystal structure of the isolated ggdef domain of wpsr from2 pseudomonas aeruginosa Phyre2 PDB 3ign chain A Region: 326 - 488 Aligned: 161 Modelled: 159 Confidence: 99.9% Identity: 33% PDB header:transferase Chain: A: PDB Molecule:diguanylate cyclase; PDBTitle: crystal structure of the ggdef domain from marinobacter2 aquaeolei diguanylate cyclase complexed with c-di-gmp -3 northeast structural genomics consortium target mqr89a Phyre2 PDB 1w25 chain A domain 3 Region: 333 - 490 Aligned: 158 Modelled: 158 Confidence: 99.9% Identity: 31% Fold: Ferredoxin-like Superfamily: Nucleotide cyclase Family: GGDEF domain Phyre2 PDB 3icl chain A Region: 330 - 490 Aligned: 158 Modelled: 160 Confidence: 99.9% Identity: 25% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:eal/ggdef domain protein; PDBTitle: x-ray structure of protein (eal/ggdef domain protein) from2 m.capsulatus, northeast structural genomics consortium3 target mcr174c Phyre2 PDB 3hva chain A Region: 327 - 487 Aligned: 159 Modelled: 161 Confidence: 99.9% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:protein fimx; PDBTitle: crystal structure of fimx ggdef domain from pseudomonas2 aeruginosa Phyre2 PDB 3qyy chain B Region: 323 - 490 Aligned: 154 Modelled: 168 Confidence: 99.9% Identity: 23% PDB header:signaling protein/inhibitor Chain: B: PDB Molecule:response regulator; PDBTitle: a novel interaction mode between a microbial ggdef domain and the bis-2 (3, 5 )-cyclic di-gmp Phyre2 PDB 3mtk chain A Region: 323 - 490 Aligned: 158 Modelled: 168 Confidence: 99.9% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:diguanylate cyclase/phosphodiesterase; PDBTitle: x-ray structure of diguanylate cyclase/phosphodiesterase from2 caldicellulosiruptor saccharolyticus, northeast structural genomics3 consortium target clr27c Phyre2 PDB 3pjw chain A Region: 312 - 490 Aligned: 175 Modelled: 179 Confidence: 99.9% Identity: 19% PDB header:lyase Chain: A: PDB Molecule:cyclic dimeric gmp binding protein; PDBTitle: structure of pseudomonas fluorescence lapd ggdef-eal dual domain, i23 Phyre2 PDB 3hvw chain A Region: 337 - 488 Aligned: 148 Modelled: 152 Confidence: 99.8% Identity: 18% PDB header:lyase Chain: A: PDB Molecule:diguanylate-cyclase (dgc); PDBTitle: crystal structure of the ggdef domain of the pa2567 protein2 from pseudomonas aeruginosa, northeast structural genomics3 consortium target par365c Phyre2 PDB 3gfz chain B Region: 326 - 490 Aligned: 133 Modelled: 135 Confidence: 98.9% Identity: 14% PDB header:hydrolase, signaling protein Chain: B: PDB Molecule:klebsiella pneumoniae blrp1; PDBTitle: klebsiella pneumoniae blrp1 ph 6 manganese/cy-digmp complex Phyre2 PDB 3p7n chain B Region: 313 - 383 Aligned: 71 Modelled: 71 Confidence: 97.6% Identity: 10% PDB header:dna binding protein Chain: B: PDB Molecule:sensor histidine kinase; PDBTitle: crystal structure of light activated transcription factor el222 from2 erythrobacter litoralis Phyre2 PDB 2qv6 chain D Region: 354 - 490 Aligned: 119 Modelled: 137 Confidence: 97.3% Identity: 16% PDB header:hydrolase Chain: D: PDB Molecule:gtp cyclohydrolase iii; PDBTitle: gtp cyclohydrolase iii from m. jannaschii (mj0145)2 complexed with gtp and metal ions Phyre2 PDB 1cjk chain A Region: 357 - 457 Aligned: 100 Modelled: 101 Confidence: 95.3% Identity: 12% PDB header:lyase/lyase/signaling protein Chain: A: PDB Molecule:adenylate cyclase, type v; PDBTitle: complex of gs-alpha with the catalytic domains of mammalian adenylyl2 cyclase: complex with adenosine 5'-(alpha thio)-triphosphate (rp),3 mg, and mn Phyre2 PDB 1wc1 chain A Region: 352 - 488 Aligned: 137 Modelled: 137 Confidence: 95.1% Identity: 16% Fold: Ferredoxin-like Superfamily: Nucleotide cyclase Family: Adenylyl and guanylyl cyclase catalytic domain Phyre2 PDB 1wc6 chain B Region: 352 - 488 Aligned: 134 Modelled: 136 Confidence: 95.1% Identity: 15% PDB header:lyase Chain: B: PDB Molecule:adenylate cyclase; PDBTitle: soluble adenylyl cyclase cyac from s. platensis in complex2 with rp-atpalphas in presence of bicarbonate Phyre2 1 c1w25B_ 2 c3ezuA_ 3 c3breA_ 4 c3i5aA_ 5 c3i5cA_ 6 c3i5bA_ 7 c3ignA_ 8 d1w25a3 9 c3iclA_ 10 c3hvaA_ 11 c3qyyB_ 12 c3mtkA_ 13 c3pjwA_ 14 c3hvwA_ 15 c3gfzB_ 16 c3p7nB_ 17 c2qv6D_ 18 c1cjkA_ 19 d1wc1a_ 20 c1wc6B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1w25B_ 100.0 29 PDB header:signaling protein Chain: B: PDB Molecule:stalked-cell differentiation controlling protein; PDBTitle: response regulator pled in complex with c-digmp 2 c3ezuA_ 100.0 25 PDB header:signaling protein Chain: A: PDB Molecule:ggdef domain protein; PDBTitle: crystal structure of multidomain protein of unknown function with2 ggdef-domain (np_951600.1) from geobacter sulfurreducens at 1.95 a3 resolution 3 c3breA_ 99.9 24 PDB header:signaling protein Chain: A: PDB Molecule:probable two-component response regulator; PDBTitle: crystal structure of p.aeruginosa pa3702 4 c3i5aA_ 99.9 24 PDB header:signaling protein Chain: A: PDB Molecule:response regulator/ggdef domain protein; PDBTitle: crystal structure of full-length wpsr from pseudomonas syringae 5 c3i5cA_ 99.9 28 PDB header:signaling protein Chain: A: PDB Molecule:fusion of general control protein gcn4 and wspr response PDBTitle: crystal structure of a fusion protein containing the leucine zipper of2 gcn4 and the ggdef domain of wspr from pseudomonas aeruginosa 6 c3i5bA_ 99.9 29 PDB header:signaling protein Chain: A: PDB Molecule:wspr response regulator; PDBTitle: crystal structure of the isolated ggdef domain of wpsr from2 pseudomonas aeruginosa 7 c3ignA_ 99.9 33 PDB header:transferase Chain: A: PDB Molecule:diguanylate cyclase; PDBTitle: crystal structure of the ggdef domain from marinobacter2 aquaeolei diguanylate cyclase complexed with c-di-gmp -3 northeast structural genomics consortium target mqr89a 8 d1w25a3 99.9 31 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:GGDEF domain 9 c3iclA_ 99.9 25 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:eal/ggdef domain protein; PDBTitle: x-ray structure of protein (eal/ggdef domain protein) from2 m.capsulatus, northeast structural genomics consortium3 target mcr174c 10 c3hvaA_ 99.9 23 PDB header:transferase Chain: A: PDB Molecule:protein fimx; PDBTitle: crystal structure of fimx ggdef domain from pseudomonas2 aeruginosa 11 c3qyyB_ 99.9 23 PDB header:signaling protein/inhibitor Chain: B: PDB Molecule:response regulator; PDBTitle: a novel interaction mode between a microbial ggdef domain and the bis-2 (3, 5 )-cyclic di-gmp 12 c3mtkA_ 99.9 18 PDB header:transferase Chain: A: PDB Molecule:diguanylate cyclase/phosphodiesterase; PDBTitle: x-ray structure of diguanylate cyclase/phosphodiesterase from2 caldicellulosiruptor saccharolyticus, northeast structural genomics3 consortium target clr27c 13 c3pjwA_ 99.9 19 PDB header:lyase Chain: A: PDB Molecule:cyclic dimeric gmp binding protein; PDBTitle: structure of pseudomonas fluorescence lapd ggdef-eal dual domain, i23 14 c3hvwA_ 99.8 18 PDB header:lyase Chain: A: PDB Molecule:diguanylate-cyclase (dgc); PDBTitle: crystal structure of the ggdef domain of the pa2567 protein2 from pseudomonas aeruginosa, northeast structural genomics3 consortium target par365c 15 c3gfzB_ 98.9 14 PDB header:hydrolase, signaling protein Chain: B: PDB Molecule:klebsiella pneumoniae blrp1; PDBTitle: klebsiella pneumoniae blrp1 ph 6 manganese/cy-digmp complex 16 c3p7nB_ 97.6 10 PDB header:dna binding protein Chain: B: PDB Molecule:sensor histidine kinase; PDBTitle: crystal structure of light activated transcription factor el222 from2 erythrobacter litoralis 17 c2qv6D_ 97.3 16 PDB header:hydrolase Chain: D: PDB Molecule:gtp cyclohydrolase iii; PDBTitle: gtp cyclohydrolase iii from m. jannaschii (mj0145)2 complexed with gtp and metal ions 18 c1cjkA_ 95.3 12 PDB header:lyase/lyase/signaling protein Chain: A: PDB Molecule:adenylate cyclase, type v; PDBTitle: complex of gs-alpha with the catalytic domains of mammalian adenylyl2 cyclase: complex with adenosine 5'-(alpha thio)-triphosphate (rp),3 mg, and mn 19 d1wc1a_ 95.1 16 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 20 c1wc6B_ 95.1 15 PDB header:lyase Chain: B: PDB Molecule:adenylate cyclase; PDBTitle: soluble adenylyl cyclase cyac from s. platensis in complex2 with rp-atpalphas in presence of bicarbonate 21 c1ybuA_ not modelled 94.5 17 PDB header:hydrolase Chain: A: PDB Molecule:lipj; PDBTitle: mycobacterium tuberculosis adenylyl cyclase rv1900c chd, in complex2 with a substrate analog. 22 c3mr7B_ not modelled 94.1 11 PDB header:hydrolase Chain: B: PDB Molecule:adenylate/guanylate cyclase/hydrolase, alpha/beta fold PDBTitle: crystal structure of adenylate/guanylate cyclase/hydrolase from2 silicibacter pomeroyi 23 c3r5gB_ not modelled 94.0 14 PDB header:lyase Chain: B: PDB Molecule:cyab; PDBTitle: crystal structure of the adenylyl cyclase cyab from p. aeruginosa 24 d1azsa_ not modelled 94.0 10 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 25 d1fx2a_ not modelled 93.2 13 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 26 c2w01C_ not modelled 91.6 14 PDB header:lyase Chain: C: PDB Molecule:adenylate cyclase; PDBTitle: crystal structure of the guanylyl cyclase cya2 27 c3uvjC_ not modelled 91.0 15 PDB header:lyase Chain: C: PDB Molecule:guanylate cyclase soluble subunit alpha-3; PDBTitle: crystal structure of the catalytic domain of the heterodimeric human2 soluble guanylate cyclase 1. 28 d1fx4a_ not modelled 90.7 17 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 29 c3et6A_ not modelled 90.0 9 PDB header:lyase Chain: A: PDB Molecule:soluble guanylyl cyclase beta; PDBTitle: the crystal structure of the catalytic domain of a eukaryotic2 guanylate cyclase 30 c1yk9A_ not modelled 89.6 12 PDB header:lyase Chain: A: PDB Molecule:adenylate cyclase; PDBTitle: crystal structure of a mutant form of the mycobacterial2 adenylyl cyclase rv1625c 31 c1y10C_ not modelled 87.8 8 PDB header:lyase Chain: C: PDB Molecule:hypothetical protein rv1264/mt1302; PDBTitle: mycobacterial adenylyl cyclase rv1264, holoenzyme, inhibited state 32 c2aq4A_ not modelled 82.9 17 PDB header:transferase Chain: A: PDB Molecule:dna repair protein rev1; PDBTitle: ternary complex of the catalytic core of rev1 with dna and dctp. 33 c1k1qA_ not modelled 82.7 17 PDB header:transcription Chain: A: PDB Molecule:dbh protein; PDBTitle: crystal structure of a dinb family error prone dna2 polymerase from sulfolobus solfataricus 34 c3gqcB_ not modelled 81.9 18 PDB header:transferase/dna Chain: B: PDB Molecule:dna repair protein rev1; PDBTitle: structure of human rev1-dna-dntp ternary complex 35 d1azsb_ not modelled 80.6 14 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 36 c3onqB_ not modelled 77.9 10 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:regulator of polyketide synthase expression; PDBTitle: crystal structure of regulator of polyketide synthase expression2 bad_0249 from bifidobacterium adolescentis 37 c1s97D_ not modelled 77.0 16 PDB header:transferase/dna Chain: D: PDB Molecule:dna polymerase iv; PDBTitle: dpo4 with gt mismatch 38 d1im4a_ not modelled 74.4 16 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 39 c3mr2A_ not modelled 63.5 26 PDB header:transferase/dna Chain: A: PDB Molecule:dna polymerase eta; PDBTitle: human dna polymerase eta in complex with normal dna and incoming2 nucleotide (nrm) 40 c2wz1B_ not modelled 62.7 12 PDB header:lyase Chain: B: PDB Molecule:guanylate cyclase soluble subunit beta-1; PDBTitle: structure of the catalytic domain of human soluble2 guanylate cyclase 1 beta 3. 41 c2oh2B_ not modelled 62.1 18 PDB header:transferase/dna Chain: B: PDB Molecule:dna polymerase kappa; PDBTitle: ternary complex of human dna polymerase 42 c2r8kB_ not modelled 57.5 13 PDB header:replication, transferase/dna Chain: B: PDB Molecule:dna polymerase eta; PDBTitle: structure of the eukaryotic dna polymerase eta in complex with 1,2-2 d(gpg)-cisplatin containing dna 43 d1xxaa_ not modelled 57.0 14 Fold:DCoH-like Superfamily:C-terminal domain of arginine repressor Family:C-terminal domain of arginine repressor 44 d2o5aa1 not modelled 54.1 17 Fold:Nucleotidyltransferase Superfamily:Nucleotidyltransferase Family:Iojap/YbeB-like 45 c3nrdB_ not modelled 53.8 11 PDB header:nucleotide binding protein Chain: B: PDB Molecule:histidine triad (hit) protein; PDBTitle: crystal structure of a histidine triad (hit) protein (smc02904) from2 sinorhizobium meliloti 1021 at 2.06 a resolution 46 c3oheA_ not modelled 53.4 10 PDB header:hydrolase Chain: A: PDB Molecule:histidine triad (hit) protein; PDBTitle: crystal structure of a histidine triad protein (maqu_1709) from2 marinobacter aquaeolei vt8 at 1.20 a resolution 47 c3imiB_ not modelled 51.7 15 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hit family protein; PDBTitle: 2.01 angstrom resolution crystal structure of a hit family protein2 from bacillus anthracis str. 'ames ancestor' 48 c1jihA_ not modelled 49.5 18 PDB header:translation Chain: A: PDB Molecule:dna polymerase eta; PDBTitle: yeast dna polymerase eta 49 d1k1sa2 not modelled 43.9 15 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 50 d1t94a2 not modelled 43.7 18 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 51 d1jiha2 not modelled 43.0 20 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 52 d1jx4a2 not modelled 42.1 17 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 53 c3af5A_ not modelled 41.6 17 PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein ph1404; PDBTitle: the crystal structure of an archaeal cpsf subunit, ph1404 from2 pyrococcus horikoshii 54 c3i24B_ not modelled 40.7 13 PDB header:hydrolase Chain: B: PDB Molecule:hit family hydrolase; PDBTitle: crystal structure of a hit family hydrolase protein from2 vibrio fischeri. northeast structural genomics consortium3 target id vfr176 55 c1xaxA_ not modelled 40.6 10 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical upf0054 protein hi0004; PDBTitle: nmr structure of hi0004, a putative essential gene product2 from haemophilus influenzae 56 d1gx1a_ not modelled 39.4 17 Fold:Bacillus chorismate mutase-like Superfamily:IpsF-like Family:IpsF-like 57 c3upsA_ not modelled 39.3 15 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:iojap-like protein; PDBTitle: crystal structure of iojap-like protein from zymomonas mobilis 58 c3hf3A_ not modelled 37.8 8 PDB header:oxidoreductase Chain: A: PDB Molecule:chromate reductase; PDBTitle: old yellow enzyme from thermus scotoductus sa-01 59 d1w55a2 not modelled 35.4 19 Fold:Bacillus chorismate mutase-like Superfamily:IpsF-like Family:IpsF-like 60 d1t0aa_ not modelled 35.1 19 Fold:Bacillus chorismate mutase-like Superfamily:IpsF-like Family:IpsF-like 61 c3v4gA_ not modelled 34.3 10 PDB header:dna binding protein Chain: A: PDB Molecule:arginine repressor; PDBTitle: 1.60 angstrom resolution crystal structure of an arginine repressor2 from vibrio vulnificus cmcp6 62 d1b4ba_ not modelled 33.5 15 Fold:DCoH-like Superfamily:C-terminal domain of arginine repressor Family:C-terminal domain of arginine repressor 63 c3f0gA_ not modelled 33.4 18 PDB header:lyase Chain: A: PDB Molecule:2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase; PDBTitle: co-crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate2 synthase with cmp 64 c1t3nB_ not modelled 33.1 22 PDB header:replication/dna Chain: B: PDB Molecule:polymerase (dna directed) iota; PDBTitle: structure of the catalytic core of dna polymerase iota in2 complex with dna and dttp 65 c2pmpA_ not modelled 32.5 15 PDB header:lyase Chain: A: PDB Molecule:2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase; PDBTitle: structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from2 the isoprenoid biosynthetic pathway of arabidopsis thaliana 66 d2id1a1 not modelled 31.6 9 Fold:Nucleotidyltransferase Superfamily:Nucleotidyltransferase Family:Iojap/YbeB-like 67 d1y23a_ not modelled 31.2 15 Fold:HIT-like Superfamily:HIT-like Family:HIT (HINT, histidine triad) family of protein kinase-interacting proteins 68 c3l7xA_ not modelled 30.9 12 PDB header:cell cycle Chain: A: PDB Molecule:putative hit-like protein involved in cell-cycle PDBTitle: the crystal structure of smu.412c from streptococcus mutans ua159 69 d1iv3a_ not modelled 30.8 17 Fold:Bacillus chorismate mutase-like Superfamily:IpsF-like Family:IpsF-like 70 c3l0oB_ not modelled 30.4 22 PDB header:hydrolase Chain: B: PDB Molecule:transcription termination factor rho; PDBTitle: structure of rna-free rho transcription termination factor from2 thermotoga maritima 71 c3k30B_ not modelled 30.2 9 PDB header:oxidoreductase Chain: B: PDB Molecule:histamine dehydrogenase; PDBTitle: histamine dehydrogenase from nocardiodes simplex 72 d1ps9a1 not modelled 30.1 17 Fold:TIM beta/alpha-barrel Superfamily:FMN-linked oxidoreductases Family:FMN-linked oxidoreductases 73 c2h90A_ not modelled 29.9 14 PDB header:oxidoreductase Chain: A: PDB Molecule:xenobiotic reductase a; PDBTitle: xenobiotic reductase a in complex with coumarin 74 d1x6va1 not modelled 28.6 15 Fold:PUA domain-like Superfamily:PUA domain-like Family:ATP sulfurylase N-terminal domain 75 d2ox6a1 not modelled 24.1 19 Fold:lambda repressor-like DNA-binding domains Superfamily:lambda repressor-like DNA-binding domains Family:YdiL-like 76 c1ps9A_ not modelled 23.4 19 PDB header:oxidoreductase Chain: A: PDB Molecule:2,4-dienoyl-coa reductase; PDBTitle: the crystal structure and reaction mechanism of e. coli 2,4-2 dienoyl coa reductase 77 c2fllA_ not modelled 23.1 23 PDB header:replication/dna Chain: A: PDB Molecule:dna polymerase iota; PDBTitle: ternary complex of human dna polymerase iota with dna and dttp 78 d1wdia_ not modelled 22.8 16 Fold:QueA-like Superfamily:QueA-like Family:QueA-like 79 c1qgeE_ not modelled 22.2 23 PDB header:hydrolase Chain: E: PDB Molecule:protein (triacylglycerol hydrolase); PDBTitle: new crystal form of pseudomonas glumae (formerly chromobacterium2 viscosum atcc 6918) lipase 80 c3l5aA_ not modelled 22.0 10 PDB header:oxidoreductase Chain: A: PDB Molecule:nadh/flavin oxidoreductase/nadh oxidase; PDBTitle: crystal structure of a probable nadh-dependent flavin oxidoreductase2 from staphylococcus aureus 81 c3p0tB_ not modelled 21.9 7 PDB header:unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of an hit-like protein from mycobacterium2 paratuberculosis 82 d2p5ma1 not modelled 21.9 9 Fold:DCoH-like Superfamily:C-terminal domain of arginine repressor Family:C-terminal domain of arginine repressor 83 d2btoa1 not modelled 21.8 12 Fold:Tubulin nucleotide-binding domain-like Superfamily:Tubulin nucleotide-binding domain-like Family:Tubulin, GTPase domain 84 c2kloA_ not modelled 21.0 8 PDB header:cell cycle Chain: A: PDB Molecule:dna replication factor cdt1; PDBTitle: structure of the cdt1 c-terminal domain 85 c3qkbB_ not modelled 21.0 21 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a protein with unknown function which belongs to2 pfam duf74 family (pepe_0654) from pediococcus pentosaceus atcc 257453 at 2.73 a resolution 86 c2zztA_ not modelled 20.3 17 PDB header:transport protein Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of the cytosolic domain of the cation2 diffusion facilitator family protein 87 c3cagF_ not modelled 19.8 9 PDB header:dna binding protein Chain: F: PDB Molecule:arginine repressor; PDBTitle: crystal structure of the oligomerization domain hexamer of the2 arginine repressor protein from mycobacterium tuberculosis in complex3 with 9 arginines. 88 d1cm3a_ not modelled 19.7 14 Fold:HPr-like Superfamily:HPr-like Family:HPr-like 89 c2btoA_ not modelled 19.5 12 PDB header:cytoskeletal protein Chain: A: PDB Molecule:tubulin btuba; PDBTitle: structure of btuba from prosthecobacter dejongeii 90 c3nx3A_ not modelled 19.5 21 PDB header:transferase Chain: A: PDB Molecule:acetylornithine aminotransferase; PDBTitle: crystal structure of acetylornithine aminotransferase (argd) from2 campylobacter jejuni 91 c2hl2A_ not modelled 19.4 11 PDB header:ligase Chain: A: PDB Molecule:threonyl-trna synthetase; PDBTitle: crystal structure of the editing domain of threonyl-trna2 synthetase from pyrococcus abyssi in complex with an3 analog of seryladenylate 92 c3nuiA_ not modelled 19.4 17 PDB header:transferase Chain: A: PDB Molecule:pyruvate transaminase; PDBTitle: crystal structure of omega-transferase from vibrio fluvialis js17 93 d3bypa1 not modelled 19.3 19 Fold:Alpha-lytic protease prodomain-like Superfamily:Cation efflux protein cytoplasmic domain-like Family:Cation efflux protein cytoplasmic domain-like 94 c3anoA_ not modelled 18.7 11 PDB header:transferase Chain: A: PDB Molecule:ap-4-a phosphorylase; PDBTitle: crystal structure of a novel diadenosine 5',5'''-p1,p4-tetraphosphate2 phosphorylase from mycobacterium tuberculosis h37rv 95 c2uzhB_ not modelled 18.4 12 PDB header:lyase Chain: B: PDB Molecule:2c-methyl-d-erythritol 2,4-cyclodiphosphate PDBTitle: mycobacterium smegmatis 2c-methyl-d-erythritol-2,4-2 cyclodiphosphate synthase (ispf) 96 d1xm5a_ not modelled 18.3 10 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Predicted metal-dependent hydrolase 97 d1vr6a1 not modelled 18.2 7 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I DAHP synthetase 98 c3l0mA_ not modelled 18.1 15 PDB header:protein binding Chain: A: PDB Molecule:drra; PDBTitle: crystal structure of rab1-activation domain and p4m domain of2 sidm/drra from legionella 99 c3ksvA_ not modelled 18.0 9 PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: hypothetical protein from leishmania major

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0