Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	K	N	N	T	A	I	I	F	G	S	L	F	F	S	C	S	V	M	A	A	N	G	T	L	A	P	T	V	V	P	M	V	N	G	G	Q	A	S	I	A	I	S	N	T	S	P	N	L	F	T	V	P	G	D	R	I	I	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?									?	?	?	?	?	?	?	?	?	?	?	?	?	?																?	?								?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	N	S	L	D	G	A	L	T	N	N	E	Q	T	A	S	G	G	V	V	V	A	T	V	N	K	K	P	F	T	F	I	L	E	T	E	R	G	L	N	L	S	I	Q	A	V	P	R	E	G	A	G	R	T	I	Q	L	V	S	D
Secondary structure
SS confidence
Disorder			?		?	?	?	?				?																																				?	?	?	?	?	?	?					?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	R	G	T	G	E	E	A	G	A	W	E	T	S	T	P	Y	E	S	L	L	V	T	I	S	Q	A	V	R	G	G	K	L	P	A	G	W	Y	Q	V	P	V	T	K	E	T	L	Q	A	P	A	G	L	S	S	V	A	D	A	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																		?	?				?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		W	T	G	N	H	L	K	M	V	R	F	A	V	E	N	K	T	L	S	A	L	N	I	R	E	S	D	F	W	Q	P	G	T	R	A	V	M	F	S	Q	P	A	S	Q	L	L	A	G	A	R	M	D	V	Y	V	I	R	D	G	E
Secondary structure
SS confidence
Disorder																			?	?																					?	?	?	?															?	?	?
Disorder confidence
		.	.
Sequence		G	N
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3cfu chain A Region: 182 - 238 Aligned: 57 Modelled: 57 Confidence: 82.1% Identity: 11% PDB header:lipoprotein Chain: A: PDB Molecule:uncharacterized lipoprotein yjha; PDBTitle: crystal structure of the yjha protein from bacillus2 subtilis. northeast structural genomics consortium target3 sr562 Phyre2 PDB 2qsv chain A Region: 189 - 235 Aligned: 44 Modelled: 47 Confidence: 61.5% Identity: 11% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of protein of unknown function from porphyromonas2 gingivalis w83 Phyre2 PDB 1l4i chain A domain 1 Region: 172 - 242 Aligned: 71 Modelled: 71 Confidence: 58.3% Identity: 18% Fold: Immunoglobulin-like beta-sandwich Superfamily: PapD-like Family: Pilus chaperone Phyre2 PDB 3bwu chain C domain 1 Region: 172 - 242 Aligned: 71 Modelled: 71 Confidence: 55.4% Identity: 13% Fold: Immunoglobulin-like beta-sandwich Superfamily: PapD-like Family: Pilus chaperone Phyre2 PDB 1p5v chain A domain 1 Region: 169 - 241 Aligned: 68 Modelled: 73 Confidence: 46.6% Identity: 15% Fold: Immunoglobulin-like beta-sandwich Superfamily: PapD-like Family: Pilus chaperone Phyre2 PDB 3jt0 chain B Region: 185 - 234 Aligned: 50 Modelled: 50 Confidence: 41.5% Identity: 10% PDB header:structural protein Chain: B: PDB Molecule:lamin-b1; PDBTitle: crystal structure of the c-terminal fragment (426-558)2 lamin-b1 from homo sapiens, northeast structural genomics3 consortium target hr5546a Phyre2 PDB 1so9 chain A Region: 184 - 236 Aligned: 53 Modelled: 53 Confidence: 39.6% Identity: 15% PDB header:metal transport Chain: A: PDB Molecule:cytochrome c oxidase assembly protein ctag; PDBTitle: solution structure of apocox11, 30 structures Phyre2 PDB 1so9 chain A Region: 184 - 236 Aligned: 53 Modelled: 53 Confidence: 39.6% Identity: 15% Fold: Ctag/Cox11 Superfamily: Ctag/Cox11 Family: Ctag/Cox11 Phyre2 PDB 1yew chain I Region: 189 - 239 Aligned: 48 Modelled: 51 Confidence: 27.5% Identity: 23% PDB header:oxidoreductase, membrane protein Chain: I: PDB Molecule:particulate methane monooxygenase, b subunit; PDBTitle: crystal structure of particulate methane monooxygenase Phyre2 PDB 3rgb chain A Region: 189 - 239 Aligned: 48 Modelled: 51 Confidence: 27.5% Identity: 23% PDB header:oxidoreductase Chain: A: PDB Molecule:methane monooxygenase subunit b2; PDBTitle: crystal structure of particulate methane monooxygenase from2 methylococcus capsulatus (bath) Phyre2 PDB 2lll chain A Region: 185 - 234 Aligned: 50 Modelled: 50 Confidence: 25.9% Identity: 16% PDB header:structural protein Chain: A: PDB Molecule:lamin-b2; PDBTitle: solution nmr structure of c-terminal globular domain of human lamin-2 b2, northeast structural genomics consortium target hr8546a Phyre2 PDB 2vzs chain A domain 2 Region: 170 - 241 Aligned: 72 Modelled: 72 Confidence: 23.9% Identity: 13% Fold: Immunoglobulin-like beta-sandwich Superfamily: beta-Galactosidase/glucuronidase domain Family: beta-Galactosidase/glucuronidase domain Phyre2 PDB 1ifr chain A Region: 185 - 234 Aligned: 50 Modelled: 50 Confidence: 22.9% Identity: 16% Fold: Immunoglobulin-like beta-sandwich Superfamily: Lamin A/C globular tail domain Family: Lamin A/C globular tail domain Phyre2 PDB 1z9s chain A Region: 172 - 241 Aligned: 70 Modelled: 70 Confidence: 22.5% Identity: 13% PDB header:chaperone/immune system Chain: A: PDB Molecule:chaperone protein caf1m; PDBTitle: crystal structure of the native chaperone:subunit:subunit2 caf1m:caf1:caf1 complex Phyre2 PDB 2bsy chain A domain 2 Region: 152 - 205 Aligned: 49 Modelled: 54 Confidence: 21.5% Identity: 10% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 1l4i chain A Region: 172 - 242 Aligned: 71 Modelled: 71 Confidence: 18.8% Identity: 17% PDB header:chaperone Chain: A: PDB Molecule:sfae protein; PDBTitle: crystal structure of the periplasmic chaperone sfae Phyre2 PDB 2j2z chain A domain 1 Region: 181 - 241 Aligned: 60 Modelled: 61 Confidence: 16.7% Identity: 17% Fold: Immunoglobulin-like beta-sandwich Superfamily: PapD-like Family: Pilus chaperone Phyre2 PDB 2h6o chain A Region: 52 - 112 Aligned: 50 Modelled: 57 Confidence: 14.5% Identity: 28% PDB header:viral protein Chain: A: PDB Molecule:major outer envelope glycoprotein gp350; PDBTitle: epstein barr virus major envelope glycoprotein Phyre2 PDB 1ivt chain A Region: 191 - 234 Aligned: 44 Modelled: 44 Confidence: 13.6% Identity: 16% Fold: Immunoglobulin-like beta-sandwich Superfamily: Lamin A/C globular tail domain Family: Lamin A/C globular tail domain Phyre2 PDB 1vyq chain A domain 1 Region: 151 - 204 Aligned: 53 Modelled: 54 Confidence: 13.4% Identity: 8% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 1 c3cfuA_ 2 c2qsvA_ 3 d1l4ia1 4 d3bwuc1 5 d1p5va1 6 c3jt0B_ 7 c1so9A_ 8 d1so9a_ 9 c1yewI_ 10 c3rgbA_ 11 c2lllA_ 12 d2vzsa2 13 d1ifra_ 14 c1z9sA_ 15 d2bsya2 16 c1l4iA_ 17 d2j2za1 18 c2h6oA_ 19 d1ivta_ 20 d1vyqa1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3cfuA_ 82.1 11 PDB header:lipoprotein Chain: A: PDB Molecule:uncharacterized lipoprotein yjha; PDBTitle: crystal structure of the yjha protein from bacillus2 subtilis. northeast structural genomics consortium target3 sr562 2 c2qsvA_ 61.5 11 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of protein of unknown function from porphyromonas2 gingivalis w83 3 d1l4ia1 58.3 18 Fold:Immunoglobulin-like beta-sandwich Superfamily:PapD-like Family:Pilus chaperone 4 d3bwuc1 55.4 13 Fold:Immunoglobulin-like beta-sandwich Superfamily:PapD-like Family:Pilus chaperone 5 d1p5va1 46.6 15 Fold:Immunoglobulin-like beta-sandwich Superfamily:PapD-like Family:Pilus chaperone 6 c3jt0B_ 41.5 10 PDB header:structural protein Chain: B: PDB Molecule:lamin-b1; PDBTitle: crystal structure of the c-terminal fragment (426-558)2 lamin-b1 from homo sapiens, northeast structural genomics3 consortium target hr5546a 7 c1so9A_ 39.6 15 PDB header:metal transport Chain: A: PDB Molecule:cytochrome c oxidase assembly protein ctag; PDBTitle: solution structure of apocox11, 30 structures 8 d1so9a_ 39.6 15 Fold:Ctag/Cox11 Superfamily:Ctag/Cox11 Family:Ctag/Cox11 9 c1yewI_ 27.5 23 PDB header:oxidoreductase, membrane protein Chain: I: PDB Molecule:particulate methane monooxygenase, b subunit; PDBTitle: crystal structure of particulate methane monooxygenase 10 c3rgbA_ 27.5 23 PDB header:oxidoreductase Chain: A: PDB Molecule:methane monooxygenase subunit b2; PDBTitle: crystal structure of particulate methane monooxygenase from2 methylococcus capsulatus (bath) 11 c2lllA_ 25.9 16 PDB header:structural protein Chain: A: PDB Molecule:lamin-b2; PDBTitle: solution nmr structure of c-terminal globular domain of human lamin-2 b2, northeast structural genomics consortium target hr8546a 12 d2vzsa2 23.9 13 Fold:Immunoglobulin-like beta-sandwich Superfamily:beta-Galactosidase/glucuronidase domain Family:beta-Galactosidase/glucuronidase domain 13 d1ifra_ 22.9 16 Fold:Immunoglobulin-like beta-sandwich Superfamily:Lamin A/C globular tail domain Family:Lamin A/C globular tail domain 14 c1z9sA_ 22.5 13 PDB header:chaperone/immune system Chain: A: PDB Molecule:chaperone protein caf1m; PDBTitle: crystal structure of the native chaperone:subunit:subunit2 caf1m:caf1:caf1 complex 15 d2bsya2 21.5 10 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 16 c1l4iA_ 18.8 17 PDB header:chaperone Chain: A: PDB Molecule:sfae protein; PDBTitle: crystal structure of the periplasmic chaperone sfae 17 d2j2za1 16.7 17 Fold:Immunoglobulin-like beta-sandwich Superfamily:PapD-like Family:Pilus chaperone 18 c2h6oA_ 14.5 28 PDB header:viral protein Chain: A: PDB Molecule:major outer envelope glycoprotein gp350; PDBTitle: epstein barr virus major envelope glycoprotein 19 d1ivta_ 13.6 16 Fold:Immunoglobulin-like beta-sandwich Superfamily:Lamin A/C globular tail domain Family:Lamin A/C globular tail domain 20 d1vyqa1 13.4 8 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 21 d2co7b1 not modelled 13.2 13 Fold:Immunoglobulin-like beta-sandwich Superfamily:PapD-like Family:Pilus chaperone 22 c2qlpC_ not modelled 13.2 12 PDB header:hydrolase Chain: C: PDB Molecule:deoxycytidine triphosphate deaminase; PDBTitle: bifunctional dctp deaminase:dutpase from mycobacterium tuberculosis,2 apo form 23 c2l0dA_ not modelled 12.3 14 PDB header:cell adhesion Chain: A: PDB Molecule:cell surface protein; PDBTitle: solution nmr structure of putative cell surface protein ma_4588 (272-2 376 domain) from methanosarcina acetivorans, northeast structural3 genomics consortium target mvr254a 24 d1rwha2 not modelled 11.9 12 Fold:Hyaluronate lyase-like, C-terminal domain Superfamily:Hyaluronate lyase-like, C-terminal domain Family:Hyaluronate lyase-like, C-terminal domain 25 c2k9uA_ not modelled 10.8 9 PDB header:structural protein Chain: A: PDB Molecule:gamma filamin; PDBTitle: solution nmr structure of the filamin-migfilin complex 26 c2bt1A_ not modelled 10.0 8 PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: epstein barr virus dutpase in complex with a,b-imino dutp 27 d1bqka_ not modelled 9.4 12 Fold:Cupredoxin-like Superfamily:Cupredoxins Family:Plastocyanin/azurin-like 28 c3qbtH_ not modelled 8.8 10 PDB header:protein transport/hydrolase Chain: H: PDB Molecule:inositol polyphosphate 5-phosphatase ocrl-1; PDBTitle: crystal structure of ocrl1 540-678 in complex with rab8a:gppnhp 29 d1ufga_ not modelled 8.8 14 Fold:Immunoglobulin-like beta-sandwich Superfamily:Lamin A/C globular tail domain Family:Lamin A/C globular tail domain 30 c4a19Q_ not modelled 8.7 25 PDB header:ribosome Chain: Q: PDB Molecule:60s ribosomal protein l36; PDBTitle: t.thermophila 60s ribosomal subunit in complex with2 initiation factor 6. this file contains 26s rrna and3 proteins of molecule 2. 31 c3lnnB_ not modelled 7.9 17 PDB header:metal transport Chain: B: PDB Molecule:membrane fusion protein (mfp) heavy metal cation efflux PDBTitle: crystal structure of zneb from cupriavidus metallidurans 32 d1e42a1 not modelled 7.9 14 Fold:Immunoglobulin-like beta-sandwich Superfamily:Clathrin adaptor appendage domain Family:Alpha-adaptin ear subdomain-like 33 c2hjjA_ not modelled 7.7 19 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein ykff; PDBTitle: solution nmr structure of protein ykff from escherichia coli.2 northeast structural genomics target er397. 34 d2hjja1 not modelled 7.7 19 Fold:dsRBD-like Superfamily:YcfA/nrd intein domain Family:YkfF-like 35 d1euwa_ not modelled 7.7 9 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 36 c2qxxA_ not modelled 7.5 12 PDB header:hydrolase Chain: A: PDB Molecule:deoxycytidine triphosphate deaminase; PDBTitle: bifunctional dctp deaminase: dutpase from mycobacterium tuberculosis2 in complex with dttp 37 c3mbqC_ not modelled 7.5 12 PDB header:hydrolase Chain: C: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: crystal structure of deoxyuridine 5-triphosphate nucleotidohydrolase2 from brucella melitensis, orthorhombic crystal form 38 c3f6iB_ not modelled 7.4 7 PDB header:chaperone Chain: B: PDB Molecule:chaperone protein faee; PDBTitle: structure of the semet labeled f4 fibrial chaperone faee 39 d1t4wa_ not modelled 7.3 9 Fold:Common fold of diphtheria toxin/transcription factors/cytochrome f Superfamily:p53-like transcription factors Family:p53 DNA-binding domain-like 40 c3rfrI_ not modelled 7.2 25 PDB header:oxidoreductase Chain: I: PDB Molecule:pmob; PDBTitle: crystal structure of particulate methane monooxygenase (pmmo) from2 methylocystis sp. strain m 41 c1pzdA_ not modelled 7.1 16 PDB header:endocytosis/exocytosis Chain: A: PDB Molecule:coatomer gamma subunit; PDBTitle: structural identification of a conserved appendage domain2 in the carboxyl-terminus of the copi gamma-subunit. 42 c2oxgD_ not modelled 7.1 6 PDB header:transport protein Chain: D: PDB Molecule:soxy protein; PDBTitle: the soxyz complex of paracoccus pantotrophus 43 c2p9oB_ not modelled 7.0 16 PDB header:hydrolase Chain: B: PDB Molecule:dutp pyrophosphatase-like protein; PDBTitle: structure of dutpase from arabidopsis thaliana 44 d1rnja_ not modelled 7.0 9 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 45 d1w8oa1 not modelled 6.9 22 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:E-set domains of sugar-utilizing enzymes 46 c3q48B_ not modelled 6.9 5 PDB header:chaperone Chain: B: PDB Molecule:chaperone cupb2; PDBTitle: crystal structure of pseudomonas aeruginosa cupb2 chaperone 47 d1v05a_ not modelled 6.9 9 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Filamin repeat (rod domain) 48 c3ca9A_ not modelled 6.6 22 PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine triphosphatase; PDBTitle: evolution of chlorella virus dutpase 49 d1hn0a3 not modelled 6.4 14 Fold:Hyaluronate lyase-like, C-terminal domain Superfamily:Hyaluronate lyase-like, C-terminal domain Family:Hyaluronate lyase-like, C-terminal domain 50 c3tqzA_ not modelled 6.3 9 PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: structure of a deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)2 from coxiella burnetii 51 c2brqA_ not modelled 6.3 11 PDB header:structural protein Chain: A: PDB Molecule:filamin a; PDBTitle: crystal structure of the filamin a repeat 21 complexed with2 the integrin beta7 cytoplasmic tail peptide 52 c2w0pB_ not modelled 6.3 11 PDB header:cell adhesion Chain: B: PDB Molecule:filamin-a; PDBTitle: crystal structure of the filamin a repeat 21 complexed with2 the migfilin peptide 53 c3iswB_ not modelled 6.3 11 PDB header:structural protein Chain: B: PDB Molecule:filamin-a; PDBTitle: crystal structure of filamin-a immunoglobulin-like repeat 21 bound to2 an n-terminal peptide of cftr 54 c2e6jA_ not modelled 6.1 11 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hydin protein; PDBTitle: solution structure of the c-terminal papd-like domain from2 human hydin protein 55 d1xs1a_ not modelled 6.0 19 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 56 d1sjna_ not modelled 5.9 17 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 57 c2brqB_ not modelled 5.9 11 PDB header:structural protein Chain: B: PDB Molecule:filamin a; PDBTitle: crystal structure of the filamin a repeat 21 complexed with2 the integrin beta7 cytoplasmic tail peptide 58 d1q5uz_ not modelled 5.8 20 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 59 c3ef4A_ not modelled 5.6 18 PDB header:electron transport Chain: A: PDB Molecule:blue copper protein; PDBTitle: crystal structure of native pseudoazurin from2 hyphomicrobium denitrificans 60 c1qunA_ not modelled 5.5 14 PDB header:chaperone/structural protein Chain: A: PDB Molecule:papd-like chaperone fimc; PDBTitle: x-ray structure of the fimc-fimh chaperone adhesin complex2 from uropathogenic e.coli 61 c1pyuD_ not modelled 5.5 18 PDB header:lyase Chain: D: PDB Molecule:aspartate 1-decarboxylase alfa chain; PDBTitle: processed aspartate decarboxylase mutant with ser25 mutated to cys 62 c3sojA_ not modelled 5.3 38 PDB header:cell adhesion Chain: A: PDB Molecule:pile; PDBTitle: francisella tularensis pilin pile 63 c3fppB_ not modelled 5.3 15 PDB header:membrane protein Chain: B: PDB Molecule:macrolide-specific efflux protein maca; PDBTitle: crystal structure of e.coli maca 64 d1x1ia2 not modelled 5.2 15 Fold:Hyaluronate lyase-like, C-terminal domain Superfamily:Hyaluronate lyase-like, C-terminal domain Family:Hyaluronate lyase-like, C-terminal domain 65 c1x1jA_ not modelled 5.2 15 PDB header:lyase Chain: A: PDB Molecule:xanthan lyase; PDBTitle: crystal structure of xanthan lyase (n194a) with a substrate.

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0