BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (410 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_P43885 D-3-phosphoglycerate dehydrogenase n=399 Tax=Bac... 597 e-169 UniRef50_A1W4D0 D-3-phosphoglycerate dehydrogenase n=26 Tax=cell... 534 e-150 UniRef50_C6W4R7 HAD-superfamily hydrolase, subfamily IB (PSPase-... 452 e-125 UniRef50_Q11WE3 Phosphoserine phosphatase and phosphoglycerate d... 419 e-115 UniRef50_A3UGW9 D-3-phosphoglycerate dehydrogenase n=2 Tax=Alpha... 418 e-115 UniRef50_A9EWF7 Phosphoglycerate dehydrogenase n=17 Tax=cellular... 415 e-114 UniRef50_D2VJX3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Naegl... 402 e-110 UniRef50_Q1CYP3 D-3-phosphoglycerate dehydrogenase n=5 Tax=cellu... 401 e-110 UniRef50_P40054 D-3-phosphoglycerate dehydrogenase 1 n=76 Tax=ce... 393 e-108 UniRef50_D0NEX4 D-3-phosphoglycerate dehydrogenase n=1 Tax=Phyto... 390 e-107 UniRef50_Q6A895 D-3-phosphoglycerate dehydrogenase n=4 Tax=Actin... 385 e-105 UniRef50_C7R3H8 D-isomer specific 2-hydroxyacid dehydrogenase NA... 384 e-105 UniRef50_C5DTI9 ZYRO0C08932p n=1 Tax=Zygosaccharomyces rouxii Re... 382 e-104 UniRef50_A6G5P3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Plesi... 367 e-100 UniRef50_C2BW43 Phosphoglycerate dehydrogenase n=1 Tax=Mobiluncu... 340 7e-92 UniRef50_A9V4F4 Predicted protein n=1 Tax=Monosiga brevicollis R... 302 2e-80 UniRef50_A4R1I1 Putative uncharacterized protein n=1 Tax=Magnapo... 292 2e-77 UniRef50_A3DM01 D-isomer specific 2-hydroxyacid dehydrogenase, N... 225 2e-57 UniRef50_Q1V300 D-3-phosphoglycerate dehydrogenase (Fragment) n=... 214 5e-54 UniRef50_A5D6D4 Phosphoglycerate dehydrogenase and related dehyd... 207 8e-52 UniRef50_A9WCW3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chlor... 205 3e-51 UniRef50_D2RHI0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Archa... 204 4e-51 UniRef50_Q1AXS3 D-3-phosphoglycerate dehydrogenase n=2 Tax=Actin... 202 2e-50 UniRef50_B0TAQ8 D-3-phosphoglycerate dehydrogenase n=4 Tax=Clost... 199 1e-49 UniRef50_A2STQ1 D-3-phosphoglycerate dehydrogenase n=5 Tax=cellu... 197 4e-49 UniRef50_O27051 D-3-phosphoglycerate dehydrogenase n=16 Tax=Arch... 197 7e-49 UniRef50_C8WVY8 D-3-phosphoglycerate dehydrogenase n=2 Tax=Alicy... 197 7e-49 UniRef50_A5FRL7 D-3-phosphoglycerate dehydrogenase n=5 Tax=Dehal... 196 1e-48 UniRef50_A8A9G4 D-isomer specific 2-hydroxyacid dehydrogenase, N... 195 3e-48 UniRef50_A7IAB7 D-3-phosphoglycerate dehydrogenase n=11 Tax=cell... 195 3e-48 UniRef50_A6UQN3 D-3-phosphoglycerate dehydrogenase n=4 Tax=Eurya... 195 3e-48 UniRef50_UPI0001C430A3 D-3-phosphoglycerate dehydrogenase n=1 Ta... 193 9e-48 UniRef50_B9L167 Phosphoglycerate dehydrogenase SerA n=2 Tax=Ther... 190 7e-47 UniRef50_Q1IVI0 D-3-phosphoglycerate dehydrogenase n=3 Tax=Acido... 189 2e-46 UniRef50_Q2G4V7 D-3-phosphoglycerate dehydrogenase n=146 Tax=cel... 189 2e-46 UniRef50_B2IJN8 D-3-phosphoglycerate dehydrogenase n=6 Tax=Bacte... 188 3e-46 UniRef50_UPI0001C31769 D-3-phosphoglycerate dehydrogenase n=1 Ta... 187 4e-46 UniRef50_A5G1V9 D-3-phosphoglycerate dehydrogenase n=3 Tax=Prote... 187 4e-46 UniRef50_B7KZ64 D-3-phosphoglycerate dehydrogenase n=16 Tax=cell... 187 7e-46 UniRef50_C6HZG9 D-3-phosphoglycerate dehydrogenase n=1 Tax=Lepto... 187 9e-46 UniRef50_Q49YF7 D-3-phosphoglycerate dehydrogenase n=55 Tax=Baci... 186 1e-45 UniRef50_B4D991 D-3-phosphoglycerate dehydrogenase n=3 Tax=Verru... 185 3e-45 UniRef50_Q5WGX7 D-3-phosphoglycerate dehydrogenase n=8 Tax=Bacil... 184 5e-45 UniRef50_O29445 D-3-phosphoglycerate dehydrogenase n=8 Tax=cellu... 183 1e-44 UniRef50_B2V7I1 D-3-phosphoglycerate dehydrogenase n=8 Tax=Aquif... 182 1e-44 UniRef50_B8CX87 D-3-phosphoglycerate dehydrogenase n=1 Tax=Halot... 181 3e-44 UniRef50_D1VVP3 Phosphoglycerate dehydrogenase n=1 Tax=Peptoniph... 181 3e-44 UniRef50_Q4L766 D-3-phosphoglycerate dehydrogenase n=3 Tax=Staph... 180 1e-43 UniRef50_UPI0001C41AB7 phosphoglycerate dehydrogenase SerA n=1 T... 180 1e-43 UniRef50_B1KZ88 D-isomer specific 2-hydroxyacid dehydrogenase fa... 179 2e-43 UniRef50_A1HMI9 Phosphoglycerate dehydrogenase n=1 Tax=Thermosin... 179 2e-43 UniRef50_B3T9W6 Putative D-isomer specific 2-hydroxyacid dehydro... 178 3e-43 UniRef50_Q67TJ9 Phosphoglycerate dehydrogenase n=1 Tax=Symbiobac... 178 3e-43 UniRef50_P73821 D-3-phosphoglycerate dehydrogenase n=40 Tax=Cyan... 178 3e-43 UniRef50_B1HVJ4 Phosphoglycerate dehydrogenase n=5 Tax=Bacillale... 177 5e-43 UniRef50_O43175 D-3-phosphoglycerate dehydrogenase n=53 Tax=Bila... 177 8e-43 UniRef50_A7HDB1 D-3-phosphoglycerate dehydrogenase n=3 Tax=Prote... 176 1e-42 UniRef50_P35136 D-3-phosphoglycerate dehydrogenase n=12 Tax=Baci... 176 1e-42 UniRef50_Q3AQU0 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chlor... 176 1e-42 UniRef50_A0LMX1 D-3-phosphoglycerate dehydrogenase n=1 Tax=Syntr... 176 2e-42 UniRef50_B6KF90 D-3-phosphoglycerate dehydrogenase, putative n=3... 175 2e-42 UniRef50_A8ZXY9 D-3-phosphoglycerate dehydrogenase n=6 Tax=Delta... 175 3e-42 UniRef50_A7BQE7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Beggi... 175 3e-42 UniRef50_B8HPZ0 D-3-phosphoglycerate dehydrogenase n=26 Tax=cell... 175 3e-42 UniRef50_A5GES6 D-3-phosphoglycerate dehydrogenase n=12 Tax=Desu... 174 4e-42 UniRef50_C8WI96 D-3-phosphoglycerate dehydrogenase n=1 Tax=Egger... 174 5e-42 UniRef50_C0QYX0 D-3-phosphoglycerate dehydrogenase n=2 Tax=Brach... 173 9e-42 UniRef50_D1JIG3 D-3-phosphoglycerate dehydrogenase n=1 Tax=uncul... 173 1e-41 UniRef50_Q18DJ4 Phosphoglycerate dehydrogenase n=13 Tax=Halobact... 173 1e-41 UniRef50_UPI0001973600 D-3-phosphoglycerate dehydrogenase n=1 Ta... 172 2e-41 UniRef50_B9L1V2 Glyoxylate reductase n=2 Tax=Thermomicrobia (cla... 172 2e-41 UniRef50_Q5SZU1 Phosphoglycerate dehydrogenase n=11 Tax=Eutheria... 172 2e-41 UniRef50_C2D1B3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Lacto... 172 2e-41 UniRef50_Q1J0H2 D-3-phosphoglycerate dehydrogenase n=8 Tax=Deino... 171 4e-41 UniRef50_B3DVF6 Phosphoglycerate dehydrogenase and ACT domains n... 170 8e-41 UniRef50_Q5HNI1 D-3-phosphoglycerate dehydrogenase n=73 Tax=Stap... 170 8e-41 UniRef50_C9LMC8 Phosphoglycerate dehydrogenase n=1 Tax=Dialister... 170 9e-41 UniRef50_C0GLG9 D-isomer specific 2-hydroxyacid dehydrogenase NA... 170 1e-40 UniRef50_A9BJ57 D-isomer specific 2-hydroxyacid dehydrogenase NA... 169 1e-40 UniRef50_A9A1H5 D-isomer specific 2-hydroxyacid dehydrogenase NA... 169 2e-40 UniRef50_A5IMH3 D-isomer specific 2-hydroxyacid dehydrogenase, N... 169 2e-40 UniRef50_A6C2G1 Phosphoglycerate dehydrogenase (SerA) n=1 Tax=Pl... 169 2e-40 UniRef50_C4V410 Phosphoglycerate dehydrogenase n=4 Tax=Veillonel... 169 2e-40 UniRef50_A4YUP8 Putative D-3-phosphoglycerate dehydrogenase (PGD... 169 2e-40 UniRef50_Q3SK87 D-isomer specific 2-hydroxyacid dehydrogenase n=... 168 3e-40 UniRef50_D2C7W6 D-isomer specific 2-hydroxyacid dehydrogenase NA... 166 1e-39 UniRef50_C7MMC6 Phosphoglycerate dehydrogenase-like oxidoreducta... 166 1e-39 UniRef50_Q2S4S4 D-3-phosphoglycerate dehydrogenase n=2 Tax=Rhodo... 166 2e-39 UniRef50_Q01W77 D-isomer specific 2-hydroxyacid dehydrogenase, N... 166 2e-39 UniRef50_A4FIF2 D-3-phosphoglycerate dehydrogenase n=1 Tax=Sacch... 166 2e-39 UniRef50_Q1PZY1 Similar to D-3-phosphoglycerate dehydrogenase (P... 165 2e-39 UniRef50_UPI00016C495D phosphoglycerate dehydrogenase n=1 Tax=Ge... 165 4e-39 UniRef50_A6C9V4 Phosphoglycerate dehydrogenase n=1 Tax=Planctomy... 164 7e-39 UniRef50_C1ZMC1 D-3-phosphoglycerate dehydrogenase n=2 Tax=Planc... 162 1e-38 UniRef50_P0A545 D-3-phosphoglycerate dehydrogenase n=57 Tax=Acti... 162 2e-38 UniRef50_Q8XPB1 D-3-phosphoglycerate dehydrogenase n=9 Tax=Clost... 162 2e-38 UniRef50_A6ULR7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 162 2e-38 UniRef50_B8I0H1 D-3-phosphoglycerate dehydrogenase n=13 Tax=Clos... 162 2e-38 UniRef50_O04130 D-3-phosphoglycerate dehydrogenase, chloroplasti... 162 3e-38 UniRef50_D2R855 D-3-phosphoglycerate dehydrogenase n=1 Tax=Pirel... 162 3e-38 UniRef50_A5IK90 D-isomer specific 2-hydroxyacid dehydrogenase, N... 162 3e-38 UniRef50_C3XIZ9 D-3-phosphoglycerate dehydrogenase n=4 Tax=Campy... 160 5e-38 UniRef50_C5BMJ8 D-isomer specific 2-hydroxyacid dehydrogenase, c... 160 7e-38 UniRef50_Q7UQL2 Phosphoglycerate dehydrogenase n=1 Tax=Rhodopire... 160 1e-37 UniRef50_B6H0R3 Pc12g10550 protein n=23 Tax=Fungi/Metazoa group ... 160 1e-37 UniRef50_Q5ZYW9 D-3-phosphoglycerate dehydrogenase n=3 Tax=Legio... 159 1e-37 UniRef50_B7P3M8 D-3-phosphoglycerate dehydrogenase, putative (Fr... 159 1e-37 UniRef50_C0C1A5 Putative uncharacterized protein n=1 Tax=Clostri... 159 1e-37 UniRef50_A8IH65 D-isomer specific 2-hydroxyacid dehydrogenase n=... 159 2e-37 UniRef50_D2RMS7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acida... 159 2e-37 UniRef50_O33116 D-3-phosphoglycerate dehydrogenase n=22 Tax=Acti... 159 2e-37 UniRef50_B7CA05 Putative uncharacterized protein n=1 Tax=Eubacte... 159 2e-37 UniRef50_A5W066 D-isomer specific 2-hydroxyacid dehydrogenase, N... 159 2e-37 UniRef50_A7GQE1 D-isomer specific 2-hydroxyacid dehydrogenase NA... 159 2e-37 UniRef50_C5RAQ7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Weiss... 159 2e-37 UniRef50_D1C3Y3 D-isomer specific 2-hydroxyacid dehydrogenase NA... 158 3e-37 UniRef50_B5YAK7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Dicty... 157 8e-37 UniRef50_Q7WEA3 Phosphoglycerate dehydrogenase n=1 Tax=Bordetell... 157 9e-37 UniRef50_B5JEX5 D-3-phosphoglycerate dehydrogenase n=2 Tax=Verru... 156 1e-36 UniRef50_C1SGT4 D-3-phosphoglycerate dehydrogenase n=1 Tax=Denit... 156 1e-36 UniRef50_C1A4S7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Gemma... 156 1e-36 UniRef50_C6PIV3 D-isomer specific 2-hydroxyacid dehydrogenase NA... 156 1e-36 UniRef50_A9CLC8 D-isomer specific 2-hydroxyacid dehydrogenase, N... 156 2e-36 UniRef50_A1RYE4 Glyoxylate reductase n=18 Tax=cellular organisms... 156 2e-36 UniRef50_B3RTC6 Putative uncharacterized protein n=1 Tax=Trichop... 155 2e-36 UniRef50_B6G9P0 Putative uncharacterized protein n=3 Tax=Bacteri... 155 2e-36 UniRef50_C4TXE2 D-3-phosphoglycerate dehydrogenase n=3 Tax=Bacte... 155 3e-36 UniRef50_C0WBM0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acida... 155 4e-36 UniRef50_D1FX73 3-phosphoglycerate dehydrogenase-like protein n=... 155 4e-36 UniRef50_UPI0000DB72A4 PREDICTED: similar to 3-phosphoglycerate ... 154 4e-36 UniRef50_D1CGN8 D-isomer specific 2-hydroxyacid dehydrogenase NA... 154 5e-36 UniRef50_Q0B0Y6 D-3-phosphoglycerate dehydrogenase n=9 Tax=Bacte... 154 5e-36 UniRef50_D1YY17 Glycerate dehydrogenase n=1 Tax=Methanocella pal... 154 5e-36 UniRef50_B1R2D5 Glycerate dehydrogenase n=6 Tax=Clostridiales Re... 154 6e-36 UniRef50_A8LSC9 D-isomer specific 2-hydroxyacid dehydrogenase NA... 154 6e-36 UniRef50_B8KU15 D-3-phosphoglycerate dehydrogenase n=1 Tax=gamma... 154 7e-36 UniRef50_C6VJE2 Phosphoglycerate dehydrogenase n=12 Tax=Lactobac... 154 7e-36 UniRef50_Q1K3M3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Desul... 154 8e-36 UniRef50_A0M1E7 D-3-phosphoglycerate dehydrogenase n=27 Tax=Bact... 153 1e-35 UniRef50_A7SFV8 Predicted protein (Fragment) n=1 Tax=Nematostell... 153 1e-35 UniRef50_Q6MN05 Phosphoglycerate dehydrogenase n=1 Tax=Bdellovib... 152 2e-35 UniRef50_B3EF68 D-isomer specific 2-hydroxyacid dehydrogenase NA... 152 2e-35 UniRef50_A1R7L8 D-3-phosphoglycerate dehydrogenase n=35 Tax=Acti... 152 2e-35 UniRef50_B1L3A6 D-isomer specific 2-hydroxyacid dehydrogenase NA... 152 2e-35 UniRef50_A4EAR0 Putative uncharacterized protein n=3 Tax=Bacteri... 152 2e-35 UniRef50_A7NGZ0 D-isomer specific 2-hydroxyacid dehydrogenase NA... 151 4e-35 UniRef50_B2I1D3 Phosphoglycerate dehydrogenase n=2 Tax=Acinetoba... 151 5e-35 UniRef50_A3MTB6 D-isomer specific 2-hydroxyacid dehydrogenase, N... 151 5e-35 UniRef50_C0BYY9 Putative uncharacterized protein n=1 Tax=Clostri... 151 5e-35 UniRef50_B5XZV2 D-isomer specific 2-hydroxyacid dehydrogenase fa... 150 7e-35 UniRef50_A6Q7Q2 D-3-phosphoglycerate dehydrogenase n=49 Tax=Epsi... 150 8e-35 UniRef50_A5N5A9 SerA n=3 Tax=Clostridium RepID=A5N5A9_CLOK5 150 8e-35 UniRef50_Q4WHR3 D-3-phosphoglycerate dehydrogenase n=3 Tax=Eurot... 150 1e-34 UniRef50_B0PHF7 Putative uncharacterized protein n=1 Tax=Anaerot... 149 1e-34 UniRef50_B2KCL9 D-isomer specific 2-hydroxyacid dehydrogenase NA... 149 1e-34 UniRef50_Q2WB35 Phosphoglycerate dehydrogenase and related dehyd... 149 2e-34 UniRef50_C8WP48 D-isomer specific 2-hydroxyacid dehydrogenase NA... 149 2e-34 UniRef50_UPI000197AFFA hypothetical protein BACCOPRO_00987 n=1 T... 149 2e-34 UniRef50_B8FRV3 D-isomer specific 2-hydroxyacid dehydrogenase NA... 149 3e-34 UniRef50_A1RDF9 D-isomer specific 2-hydroxyacid dehydrogenase fa... 149 3e-34 UniRef50_Q7D366 Putative phosphoglycerate dehydrogenase n=1 Tax=... 148 3e-34 UniRef50_UPI0001972FE9 D-isomer specific 2-hydroxyacid dehydroge... 148 4e-34 UniRef50_Q0W672 Glycerate dehydrogenase n=2 Tax=Archaea RepID=Q0... 148 5e-34 UniRef50_UPI0001BC4ADC hypothetical protein FulcA4_06865 n=1 Tax... 147 5e-34 UniRef50_Q01ZI8 D-isomer specific 2-hydroxyacid dehydrogenase, N... 147 7e-34 UniRef50_Q5WLJ2 D-3-phosphoglycerate dehydrogenase n=7 Tax=Bacte... 147 7e-34 UniRef50_A4RX85 Predicted protein n=8 Tax=cellular organisms Rep... 147 9e-34 UniRef50_C5EHH3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Clost... 147 9e-34 UniRef50_C9MSC4 Glycerate dehydrogenase n=3 Tax=Prevotella RepID... 147 1e-33 UniRef50_D0MDQ9 D-isomer specific 2-hydroxyacid dehydrogenase NA... 147 1e-33 UniRef50_Q0AFR7 D-3-phosphoglycerate dehydrogenase n=22 Tax=Bact... 146 2e-33 UniRef50_B9KWQ6 D-isomer specific 2-hydroxyacid dehydrogenase, c... 146 2e-33 UniRef50_Q04DF1 D-3-phosphoglycerate dehydrogenase n=1 Tax=Oenoc... 145 2e-33 UniRef50_A1HSQ7 D-isomer specific 2-hydroxyacid dehydrogenase, N... 145 2e-33 UniRef50_C2HP35 Glyoxylate reductase n=10 Tax=Lactobacillus RepI... 145 2e-33 UniRef50_UPI00016C0F1F D-isomer specific 2-hydroxyacid dehydroge... 145 2e-33 UniRef50_A9BSM0 D-isomer specific 2-hydroxyacid dehydrogenase NA... 145 2e-33 UniRef50_Q03W66 D-3-phosphoglycerate dehydrogenase n=3 Tax=Leuco... 145 2e-33 UniRef50_Q4PK14 Predicted D-isomer specific 2-hydroxyacid dehydr... 145 3e-33 UniRef50_B0K2Z0 D-isomer specific 2-hydroxyacid dehydrogenase, N... 145 3e-33 UniRef50_Q2RH37 D-isomer specific 2-hydroxyacid dehydrogenase, N... 145 3e-33 UniRef50_A8MCX1 D-isomer specific 2-hydroxyacid dehydrogenase NA... 145 4e-33 UniRef50_C9RL30 D-isomer specific 2-hydroxyacid dehydrogenase NA... 144 4e-33 UniRef50_Q30V14 D-isomer specific 2-hydroxyacid dehydrogenase fa... 144 5e-33 UniRef50_A0Q365 D-isomer specific 2-hydroxyacid dehydrogenases n... 144 5e-33 UniRef50_B0KD78 D-isomer specific 2-hydroxyacid dehydrogenase, N... 144 5e-33 UniRef50_A0LN07 D-isomer specific 2-hydroxyacid dehydrogenase, N... 144 6e-33 UniRef50_C4DLZ3 Lactate dehydrogenase-like oxidoreductase n=1 Ta... 144 8e-33 UniRef50_A7VWU5 Putative uncharacterized protein n=1 Tax=Clostri... 144 8e-33 UniRef50_B0NG91 Putative uncharacterized protein n=1 Tax=Clostri... 144 8e-33 UniRef50_D1RHC1 D-3-phosphoglycerate dehydrogenase n=1 Tax=Legio... 144 8e-33 UniRef50_Q46AE6 Glycerate dehydrogenase n=2 Tax=Methanosarcina R... 144 8e-33 UniRef50_A4WXD4 Dimethylmenaquinone methyltransferase n=2 Tax=Al... 143 9e-33 UniRef50_C2HJZ3 Possible glyoxylate reductase n=2 Tax=Finegoldia... 143 1e-32 UniRef50_Q6AMI7 Related to D-3-phosphoglycerate dehydrogenase n=... 143 1e-32 UniRef50_B6YWH0 Glyoxylate reductase n=95 Tax=cellular organisms... 143 1e-32 UniRef50_UPI0001C42ACE D-isomer specific 2-hydroxyacid dehydroge... 142 2e-32 UniRef50_Q8EP33 Glycerate dehydrogenase n=2 Tax=Bacillaceae RepI... 142 2e-32 UniRef50_Q2NA55 D-isomer specific 2-hydroxyacid dehydrogenase fa... 142 2e-32 UniRef50_Q2YBY5 D-isomer specific 2-hydroxyacid dehydrogenase, N... 142 2e-32 UniRef50_A7VV70 Putative uncharacterized protein n=1 Tax=Clostri... 142 2e-32 UniRef50_B0MXJ8 Putative uncharacterized protein n=1 Tax=Alistip... 142 2e-32 UniRef50_B9KTQ4 D-isomer specific 2-hydroxyacid dehydrogenase, N... 142 2e-32 UniRef50_C4ZHF5 Phosphoglycerate dehydrogenase, putative n=3 Tax... 142 2e-32 UniRef50_A4FHH0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Sacch... 142 2e-32 UniRef50_A7HM61 Glyoxylate reductase n=6 Tax=cellular organisms ... 142 3e-32 UniRef50_C1XXK0 Phosphoglycerate dehydrogenase-like oxidoreducta... 142 3e-32 UniRef50_A4FIJ9 D-3-phosphoglycerate dehydrogenase n=1 Tax=Sacch... 142 3e-32 UniRef50_C0C032 Putative uncharacterized protein n=2 Tax=Firmicu... 142 3e-32 UniRef50_C0CRA6 Putative uncharacterized protein n=2 Tax=Clostri... 142 3e-32 UniRef50_A3PPC6 D-isomer specific 2-hydroxyacid dehydrogenase, N... 141 3e-32 UniRef50_C5EP42 D-3-phosphoglycerate dehydrogenase n=2 Tax=Clost... 141 4e-32 UniRef50_B0PD17 Putative uncharacterized protein n=1 Tax=Anaerot... 141 4e-32 UniRef50_A0M755 D-3-phosphoglycerate dehydrogenase n=24 Tax=Bact... 141 4e-32 UniRef50_B1HNB2 D-3-phosphoglycerate dehydrogenase n=7 Tax=Firmi... 141 5e-32 UniRef50_C7TNB9 D-isomer specific 2-hydroxyacid dehydrogenase, N... 141 5e-32 UniRef50_UPI0001973D95 D-3-phosphoglycerate dehydrogenase n=1 Ta... 141 5e-32 UniRef50_C7H045 D-isomer specific 2-hydroxyacid dehydrogenase fa... 141 5e-32 UniRef50_A6FZB7 Putative dehydrogenase n=1 Tax=Plesiocystis paci... 140 7e-32 UniRef50_A6CKS4 Putative uncharacterized protein n=2 Tax=Bacilla... 140 8e-32 UniRef50_Q1GAM7 D-isomer specific 2-hydroxyacid dehydrogenase n=... 140 8e-32 UniRef50_C6PW23 D-isomer specific 2-hydroxyacid dehydrogenase NA... 140 8e-32 UniRef50_B3T034 Putative D-isomer specific 2-hydroxyacid dehydro... 140 9e-32 UniRef50_Q65WI5 SerA protein n=1 Tax=Mannheimia succiniciproduce... 140 1e-31 UniRef50_Q031D4 D-3-phosphoglycerate dehydrogenase n=9 Tax=Strep... 139 1e-31 UniRef50_Q03YV3 Lactate dehydrogenase related enzyme n=2 Tax=Leu... 139 2e-31 UniRef50_C7RDP2 D-isomer specific 2-hydroxyacid dehydrogenase NA... 139 2e-31 UniRef50_B9Z038 D-isomer specific 2-hydroxyacid dehydrogenase NA... 139 3e-31 UniRef50_D1W6S1 4-phosphoerythronate dehydrogenase n=4 Tax=Prevo... 139 3e-31 UniRef50_UPI0001B416D9 D-3-phosphoglycerate dehydrogenase n=1 Ta... 138 4e-31 UniRef50_B1M476 D-isomer specific 2-hydroxyacid dehydrogenase NA... 138 4e-31 UniRef50_A1AQ02 D-isomer specific 2-hydroxyacid dehydrogenase, N... 137 8e-31 UniRef50_Q46NL3 D-isomer specific 2-hydroxyacid dehydrogenase, c... 137 9e-31 UniRef50_D1CI00 D-isomer specific 2-hydroxyacid dehydrogenase NA... 136 1e-30 UniRef50_A8HPR9 Predicted protein (Fragment) n=1 Tax=Chlamydomon... 136 1e-30 UniRef50_B2IKB7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 136 1e-30 UniRef50_Q0K073 D-3-Phosphoglycerate dehydrogenase n=5 Tax=cellu... 136 1e-30 UniRef50_D1Y1W8 Phosphoglycerate dehydrogenase n=1 Tax=Pyramidob... 136 1e-30 UniRef50_A1W7V5 D-isomer specific 2-hydroxyacid dehydrogenase, N... 136 2e-30 UniRef50_C2BTH2 D-3-phosphoglycerate dehydrogenase n=1 Tax=Mobil... 136 2e-30 UniRef50_Q71VT7 D-isomer specific 2-hydroxyacid dehydrogenase fa... 136 2e-30 UniRef50_Q1WVK4 D-3-phosphoglycerate dehydrogenase n=7 Tax=Lacto... 135 2e-30 UniRef50_B0NEH0 Putative uncharacterized protein n=1 Tax=Clostri... 135 2e-30 UniRef50_B2Q5T3 Putative uncharacterized protein n=2 Tax=cellula... 135 2e-30 UniRef50_B3V649 Glyoxylate reductase n=1 Tax=uncultured marine c... 135 2e-30 UniRef50_A9A5A9 Glyoxylate reductase n=2 Tax=Thaumarchaeota RepI... 135 2e-30 UniRef50_A8R8D3 Putative uncharacterized protein n=2 Tax=unclass... 135 2e-30 UniRef50_C0WBB3 D-isomer specific 2-hydroxyacid dehydrogenase n=... 135 2e-30 UniRef50_C6PA05 D-isomer specific 2-hydroxyacid dehydrogenase NA... 135 3e-30 UniRef50_D1NAT8 D-isomer specific 2-hydroxyacid dehydrogenase NA... 135 3e-30 >UniRef50_P43885 D-3-phosphoglycerate dehydrogenase n=399 Tax=Bacteria RepID=SERA_HAEIN Length = 410 Score = 597 bits (1540), Expect = e-169, Method: Compositional matrix adjust. Identities = 290/409 (70%), Positives = 341/409 (83%), Gaps = 3/409 (0%) Query: 3 KVSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSR 62 KVSL+K KIKF+L EGVHQ AL++L AAGYTNI+++K ALD ++LKE+I+D HFIGLRSR Sbjct: 4 KVSLDKSKIKFVLFEGVHQSALDTLHAAGYTNIDYYKKALDGDELKEAIKDVHFIGLRSR 63 Query: 63 THLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLL 122 THLT ++I AA KL+A+GCFCIGTNQVDL+AA RGIPVFNAPFSNTRSVAELV+GE+LL Sbjct: 64 THLTAEMIEAAPKLIAVGCFCIGTNQVDLNAAKARGIPVFNAPFSNTRSVAELVLGEILL 123 Query: 123 LLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI 182 L+R VP+ANA+ HRGVWNK A GS E RGKKLGIIGYGHIG+QL I+AESLGM VYFYDI Sbjct: 124 LMRNVPQANAEVHRGVWNKSATGSHEVRGKKLGIIGYGHIGSQLSIIAESLGMDVYFYDI 183 Query: 183 ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 ENKLPLGNA QV+ L +LL+ DVVSLHVPE PSTKN+M I+ +K G++LINA+RGT Sbjct: 184 ENKLPLGNAKQVRSLEELLSSCDVVSLHVPELPSTKNLMNVARIAQLKQGAILINAARGT 243 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 VVDI AL AL L GAAIDVFP EPA+ ++ F SPL EFDNV+LTPHIGGST EAQE Sbjct: 244 VVDIDALAQALKDGKLQGAAIDVFPVEPASINEEFISPLREFDNVILTPHIGGSTAEAQE 303 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLH-GGRRLMHIHENRPGVLTALNKIFAEQ 361 NIG EVAGK +KYSDNGSTLS+VNFPEVSLP H G +RL+HIHENRPG+L LN+IF E Sbjct: 304 NIGFEVAGKFVKYSDNGSTLSSVNFPEVSLPEHEGTKRLLHIHENRPGILNKLNQIFVEA 363 Query: 362 GVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY 410 +NIAAQYLQT ++GYVV+D+E ++ A L +K I GTIRAR+LY Sbjct: 364 NLNIAAQYLQTDPKIGYVVVDVETND--ASPLLTKLKEIDGTIRARVLY 410 >UniRef50_A1W4D0 D-3-phosphoglycerate dehydrogenase n=26 Tax=cellular organisms RepID=A1W4D0_ACISJ Length = 434 Score = 534 bits (1376), Expect = e-150, Method: Compositional matrix adjust. Identities = 260/411 (63%), Positives = 323/411 (78%), Gaps = 3/411 (0%) Query: 1 MAKVSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLR 60 MAK SL+K KIKFLL+EG+H A+E LR+AGYT +E GAL+ E+L+ I D HFIG+R Sbjct: 26 MAKTSLDKSKIKFLLLEGIHPSAVEVLRSAGYTQVEVLAGALEGEELRRKIADVHFIGIR 85 Query: 61 SRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGEL 120 SRT LT DV A KLVA+GCFCIGTNQVDL+AA +RGI VFNAP+SNTRSVAELV+ E Sbjct: 86 SRTQLTADVFAHAHKLVAVGCFCIGTNQVDLNAARERGIAVFNAPYSNTRSVAELVLAEA 145 Query: 121 LLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 +LLLRGVPE NA AHRG W K A ++E RGK LGI+GYG IGTQL +LAE+LGM+V F+ Sbjct: 146 ILLLRGVPEKNAAAHRGGWLKSATNAYEIRGKTLGIVGYGSIGTQLSVLAEALGMHVIFH 205 Query: 181 DIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 D+ +KLPLGNA QV L +LL +D+V+LHVPE PST+ M+GA EI+ MKPG +LINASR Sbjct: 206 DVVHKLPLGNARQVGSLHELLGQADIVTLHVPELPSTQWMIGAAEIAAMKPGGILINASR 265 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 GTVV+I L AL +L GAA+DVFP EP +N D F SPL DN LLTPHIGGST EA Sbjct: 266 GTVVEIDPLAQALKGGNLLGAAVDVFPVEPKSNKDEFVSPLRGLDNALLTPHIGGSTMEA 325 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGR-RLMHIHENRPGVLTALNKIFA 359 Q NIGLEVA KL++YSDNG++ S+VNFPEV+LP H G+ RL+H+H N PGVL+ +N I + Sbjct: 326 QANIGLEVAEKLVRYSDNGTSTSSVNFPEVALPEHAGKHRLLHVHHNVPGVLSQINSILS 385 Query: 360 EQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY 410 + +NIAAQYLQT+ ++GYVVID++A ++ AL+ + +PGTIR+R+LY Sbjct: 386 DNHINIAAQYLQTNEKIGYVVIDLDARS--SDLALEKLAQVPGTIRSRVLY 434 >UniRef50_C6W4R7 HAD-superfamily hydrolase, subfamily IB (PSPase-like) n=40 Tax=Bacteria RepID=C6W4R7_DYAFD Length = 635 Score = 452 bits (1163), Expect = e-125, Method: Compositional matrix adjust. Identities = 223/407 (54%), Positives = 292/407 (71%), Gaps = 4/407 (0%) Query: 5 SLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTH 64 S K +IK LL+E VH A ++ G+ N+EF KGALD+++L E I+D IG+RS+T Sbjct: 232 SYPKSRIKVLLLENVHPVARKAFEDEGF-NVEFVKGALDEDELCERIKDVSIIGIRSKTT 290 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 +T+ V+ A +L+AIG FCIGTNQ+DLD AAK+GI VFNAP+SNTRSV EL +GE++LL+ Sbjct: 291 ITKRVLEHANRLMAIGAFCIGTNQIDLDEAAKKGIAVFNAPYSNTRSVVELAVGEMILLI 350 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 R + + H+G+W+K A GSFE RGKKLG++GYG IGTQL ++AE+LGM VYFYD Sbjct: 351 RNIVGKSNSMHKGIWDKSANGSFEIRGKKLGMVGYGSIGTQLSVVAEALGMDVYFYDAVE 410 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 KL +GNA +V L +LL MSDV+SLHV NM+G +E LMK G + +N SRG VV Sbjct: 411 KLSIGNAKKVNTLEELLAMSDVLSLHVDGRKENTNMIGKREFDLMKDGVIFLNLSRGHVV 470 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 DI AL DA+ S +AGA +DVFP EP TN + F S L NV+LTPHIGGST+EAQENI Sbjct: 471 DIKALADAVKSGKVAGAGVDVFPKEPKTNDEMFESELLGLPNVILTPHIGGSTEEAQENI 530 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEVSLP-LHGGRRLMHIHENRPGVLTALNKIFAEQGV 363 G V KL+++ +NGS+ +VNFPEV LP L RL+HIH N PGVL LN+IFA+ + Sbjct: 531 GHFVPSKLLEFMNNGSSYGSVNFPEVQLPKLKDSHRLLHIHANVPGVLAKLNQIFAKNNI 590 Query: 364 NIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY 410 NI QYL+T+ +GYV++DI +D E+ +Q +K + GTIR R+LY Sbjct: 591 NITGQYLKTNEHIGYVIVDIA--KDYTEEFIQEVKEVEGTIRFRMLY 635 >UniRef50_Q11WE3 Phosphoserine phosphatase and phosphoglycerate dehydrogenase (D-3-phosphoglycerate dehydrogenase) fusion n=85 Tax=Bacteria RepID=Q11WE3_CYTH3 Length = 633 Score = 419 bits (1076), Expect = e-115, Method: Compositional matrix adjust. Identities = 207/408 (50%), Positives = 278/408 (68%), Gaps = 4/408 (0%) Query: 4 VSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRT 63 +S K++IK LL+E +H A + GYT +E AL++++L E I+D IG+RS+T Sbjct: 229 ISYPKNRIKVLLLENIHTDAFKLFSEEGYT-VEVIASALEEDELIEKIKDVSIIGIRSKT 287 Query: 64 HLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLL 123 +T V+ A KL+AIG FCIGTNQ+DL AA +G+ VFNAPFSNTRSV EL IGE+++L Sbjct: 288 TITAKVLEHAPKLIAIGAFCIGTNQIDLKAAQMKGVAVFNAPFSNTRSVVELAIGEIIML 347 Query: 124 LRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE 183 R E + + H G W+K A SFE RGKKLG++GYG+IG+QL ++AESLGM VY+YDI Sbjct: 348 YRRTLEKSMQMHAGKWDKSAKNSFEIRGKKLGLVGYGNIGSQLSVIAESLGMVVYYYDIV 407 Query: 184 NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 +L LGNA + L +LLN DVVSLHV S K M GAKE + M+ GS+ +N +RG V Sbjct: 408 ERLSLGNAKKCSSLKELLNTVDVVSLHVDGRASNKGMFGAKEFNEMRQGSIFLNLARGPV 467 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 D+ AL + L S + GA +DV+ EP N + F + + NV+LTPHIGGST+EAQ N Sbjct: 468 TDLKALSENLKSGKILGAGLDVYEYEPKNNDEEFINDVRGLPNVILTPHIGGSTEEAQSN 527 Query: 304 IGLEVAGKLIKYSDNGSTLSAVNFPEVSLP-LHGGRRLMHIHENRPGVLTALNKIFAEQG 362 IG V ++ Y +NG+TL +VNFP + LP L G R MH+HEN+PG+L +N +FA+ Sbjct: 528 IGNFVPNRITDYINNGTTLHSVNFPNIQLPELQEGHRFMHLHENQPGILAKINNLFAKHN 587 Query: 363 VNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY 410 +NI AQYL+T+ Q+GYV+ DI D ++ L +K IPGTIR R LY Sbjct: 588 INILAQYLKTNEQVGYVITDIAKIYD--KEVLDELKEIPGTIRFRTLY 633 >UniRef50_A3UGW9 D-3-phosphoglycerate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=A3UGW9_9RHOB Length = 407 Score = 418 bits (1075), Expect = e-115, Method: Compositional matrix adjust. Identities = 214/398 (53%), Positives = 276/398 (69%), Gaps = 4/398 (1%) Query: 14 LLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAA 73 LL+E VH A +L+ AG ++ G+ D QL+ I A +G+RSRTH+ +++AA Sbjct: 10 LLLENVHPDADNALQTAGPVTVKRLSGSPDRAQLESEIASASVLGIRSRTHVDAALLDAA 69 Query: 74 EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAK 133 ++L A+GCFCIGTNQVDL AAA+RG+PVFNAPF+NTRSVAEL + +++L+R +PE Sbjct: 70 KELQAVGCFCIGTNQVDLVAAAERGVPVFNAPFANTRSVAELTMASVIMLMRRIPEKMFA 129 Query: 134 AHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQ 193 RG W K A G+ E R KKLGIIGYG+IG QL ++A +LGM+VY+YDI KL GNA Sbjct: 130 IQRGEWLKTADGANEVRKKKLGIIGYGNIGAQLSVIASALGMHVYYYDIAPKLAHGNARP 189 Query: 194 VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDAL 253 + L D+L DVV+LHVP P TKNM+G +I+LMK G+ LIN +RG +VD+ AL DAL Sbjct: 190 MDTLDDILTECDVVTLHVPSTPRTKNMIGKDQIALMKHGAFLINQARGDLVDVDALADAL 249 Query: 254 ASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLI 313 S HLAGAA+DVFP EP + + F SPL NV+LTPHIGGST EAQ+ IGL+ AGKL Sbjct: 250 NSGHLAGAAVDVFPVEPKSKDEKFESPLTRCANVILTPHIGGSTLEAQQAIGLDAAGKLA 309 Query: 314 KYSDNGSTLSAVNFPEVSL-PLHGGR-RLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQ 371 +Y GST AVNFPEV P+ GR R++ H NRPG L LN + G N+AAQ+LQ Sbjct: 310 RYLHEGSTTFAVNFPEVEPGPIQPGRTRILAPHRNRPGFLRRLNDAAEQAGANVAAQFLQ 369 Query: 372 TSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 T +GY V D+E ++ E L ++AI GTIRARL+ Sbjct: 370 TKGDLGYAVADLEG--ELPEDFLDRVRAIDGTIRARLI 405 >UniRef50_A9EWF7 Phosphoglycerate dehydrogenase n=17 Tax=cellular organisms RepID=A9EWF7_SORC5 Length = 419 Score = 415 bits (1066), Expect = e-114, Method: Compositional matrix adjust. Identities = 203/404 (50%), Positives = 283/404 (70%), Gaps = 4/404 (0%) Query: 8 KDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 K+ +K LL+E +HQ A E R+ + IE A+ +++L ++ +G+RS+TH+T Sbjct: 19 KEPVKVLLLENIHQSAHELFRSRSF-EIETRSSAMKEDELIAALAGVDMLGIRSKTHVTA 77 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 V+ A+KL++IGCFCIGTNQVDLDAA +RG+PVFNAPFSNTRSVAE++I E ++L R + Sbjct: 78 RVLEKADKLLSIGCFCIGTNQVDLDAANRRGVPVFNAPFSNTRSVAEMIIAESIMLARQL 137 Query: 128 PEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP 187 + + + H G W K++ +E RGK +G+IGYGHIG QLG+LAE++GM V +YDI KLP Sbjct: 138 GDRSREVHAGTWKKVSKACYEIRGKTIGLIGYGHIGQQLGVLAEAMGMRVVYYDIAQKLP 197 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 +GN + L LL SD VSLHVP P T NM+GA E++ M+ G+ L+NASRG+VV IP Sbjct: 198 MGNNRALPTLEALLAESDFVSLHVPATPETHNMIGAAELAHMRKGAYLLNASRGSVVVIP 257 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL +AL S HLAGAAIDV+P EP +NSD F + L + NV+LTPHIGGST+EAQE IG E Sbjct: 258 ALAEALKSGHLAGAAIDVYPEEPESNSDGFLTELQKLPNVILTPHIGGSTEEAQEAIGRE 317 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVSL-PLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIA 366 V+ L + G+T AVNFP V L PL R++++H N PGVL +N+I ++ NI Sbjct: 318 VSRALTQLVTTGATTGAVNFPNVELPPLKATHRILNVHRNVPGVLRDVNRIVSDVNANID 377 Query: 367 AQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY 410 +Q L T A +GY+++D+ +DV+ + + + A+ +IR R+LY Sbjct: 378 SQVLSTDANIGYLIMDL--SQDVSAEVSRRIGALETSIRTRVLY 419 >UniRef50_D2VJX3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VJX3_NAEGR Length = 405 Score = 402 bits (1033), Expect = e-110, Method: Compositional matrix adjust. Identities = 204/409 (49%), Positives = 282/409 (68%), Gaps = 9/409 (2%) Query: 5 SLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTH 64 S K IK LL+E + Q A++ + G+ +E +L +E+L I D H +G+RS+T Sbjct: 3 SYPKHLIKVLLLENISQTAVDLFKKEGF-QVESVSKSLSEEELTVKIEDVHLVGIRSKTK 61 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 LTE V++ A+KL A+GC+CIGT+QVDL+ K+GIPVFN+P++NTRSVAEL + E+++L Sbjct: 62 LTEKVLSNAKKLKAVGCYCIGTDQVDLECCEKKGIPVFNSPYANTRSVAELAMSEIVMLS 121 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 R V E H+G W K+A +E RGK LGI+GYGH+G+QLG+LAE GM V +YDIE+ Sbjct: 122 RKVSEHVKSLHQGHWYKIAKDCYEIRGKILGIVGYGHVGSQLGLLAEGFGMSVIYYDIEH 181 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 KLPLGNA V + +L+ + VSLHVP+ T N++G +I+ M+ GS L+N SRG+VV Sbjct: 182 KLPLGNAKPVDSMEQVLSTAHFVSLHVPKTEQTNNLIGEAQIAQMQKGSYLLNLSRGSVV 241 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDP-FTSPLCEFDNVLLTPHIGGSTQEAQEN 303 D+ AL AL S HL G A+DVFPTEP + D F+SPL N +LTPHIGGST EAQ+ Sbjct: 242 DVNALASALKSGHLHGCAVDVFPTEPEKDGDNVFSSPLQNCPNTILTPHIGGSTIEAQDA 301 Query: 304 IGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLH--GGRRLMHIHENRPGVLTALNKIFAEQ 361 IG EVA KLI Y + G TL +VNFP+++ P+H G RL+HIH NR GVL ++N + Q Sbjct: 302 IGKEVAQKLISYMNEGITLGSVNFPQIN-PVHYAGCHRLLHIHVNRHGVLKSINALL--Q 358 Query: 362 GVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY 410 N+ +Q L T+ +GY+V IE D+ VAE+ + +K + TI+AR+L+ Sbjct: 359 DYNVVSQLLGTTKHIGYMV--IELDKSVAEEVFKQIKELESTIKARVLF 405 >UniRef50_Q1CYP3 D-3-phosphoglycerate dehydrogenase n=5 Tax=cellular organisms RepID=Q1CYP3_MYXXD Length = 417 Score = 401 bits (1031), Expect = e-110, Method: Compositional matrix adjust. Identities = 206/400 (51%), Positives = 276/400 (69%), Gaps = 4/400 (1%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + LL+E +H A E L A G+ +E AL ++L E ++ H +G+RS+T + + Sbjct: 20 FRALLLENIHPSAGEMLAAEGF-QVERVSSALKPDELAERLKGVHLLGIRSKTTVPLAAL 78 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AE L+AIG FCIGTNQVDL +A GIPVFNAPFSNTRSVAE+VI E+++L R + E Sbjct: 79 EHAENLLAIGAFCIGTNQVDLTSANTHGIPVFNAPFSNTRSVAEMVIAEVIVLTRQLFER 138 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + + H G W K+A GS E RGK LGIIGYGHIG+QLG++AE+LGM V ++D+ KLPLGN Sbjct: 139 SQEVHAGQWRKVATGSHEVRGKTLGIIGYGHIGSQLGVIAEALGMRVLYFDVMTKLPLGN 198 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 A L +LL SD V+LHVP P+T MMGA++I+ MK G+ LINASRGTVVDI AL Sbjct: 199 AQPAVTLEELLGASDFVTLHVPALPTTHMMMGAEQIAQMKKGACLINASRGTVVDIDALA 258 Query: 251 DALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAG 310 AL S+HL GAA+DV+P EP +NSD F + L NV+LTPHIGGST+EAQ +IG EVA Sbjct: 259 RALQSQHLGGAAVDVYPEEPESNSDGFVTALQGLPNVVLTPHIGGSTEEAQASIGKEVAT 318 Query: 311 KLIKYSDNGSTLSAVNFPEVSLPL-HGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQY 369 L+KY G++ AVNFP + PL G R++++H N PGVL +N+I ++ NI AQ Sbjct: 319 SLLKYFKAGASTGAVNFPNIEAPLIPGTHRILNVHRNIPGVLRDINRIVSDLNANIHAQV 378 Query: 370 LQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 L T A +GY+++D+ D+DV+ +A+ + I+ R+L Sbjct: 379 LSTDANIGYLLMDL--DQDVSTPVCEAIAGLETDIKTRIL 416 >UniRef50_P40054 D-3-phosphoglycerate dehydrogenase 1 n=76 Tax=cellular organisms RepID=SERA_YEAST Length = 469 Score = 393 bits (1010), Expect = e-108, Method: Compositional matrix adjust. Identities = 199/414 (48%), Positives = 277/414 (66%), Gaps = 17/414 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K LL+E V+Q A+ GY +EF+K +L +E+L E I+D H IG+RS+T LT +V+ Sbjct: 59 MKILLLENVNQTAITIFEEQGY-QVEFYKSSLPEEELIEKIKDVHAIGIRSKTRLTSNVL 117 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A+ LV IGCFCIGTNQVDLD A RGI VFN+PFSN+RSVAELVI E++ L R + + Sbjct: 118 QHAKNLVCIGCFCIGTNQVDLDYATSRGIAVFNSPFSNSRSVAELVIAEIISLARQLGDR 177 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + + H G WNK+AA +E RGK LGIIGYGHIG+QL +LAE++G++V +YDI + LG Sbjct: 178 SIELHTGTWNKVAARCWEVRGKTLGIIGYGHIGSQLSVLAEAMGLHVLYYDIVTIMALGT 237 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 A QV L +LLN SD V+LHVP P T+ M+ A + + MK G+ +INASRGTVVDIP+L Sbjct: 238 ARQVSTLDELLNKSDFVTLHVPATPETEKMLSAPQFAAMKDGAYVINASRGTVVDIPSLI 297 Query: 251 DALASKHLAGAAIDVFPTEPATNSD--------PFTSPLCEFDNVLLTPHIGGSTQEAQE 302 A+ + +AGAA+DV+P EPA N + +TS L N++LTPHIGGST+EAQ Sbjct: 298 QAVKANKIAGAALDVYPHEPAKNGEGSFNDELNSWTSELVSLPNIILTPHIGGSTEEAQS 357 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVNFPEVSLP-----LHGGRRLMHIHENRPGVLTALNKI 357 +IG+EVA L KY + G+++ +VNFPEV+L R+++IH+N PGVL +N I Sbjct: 358 SIGIEVATALSKYINEGNSVGSVNFPEVALKSLSYDQENTVRVLYIHQNVPGVLKTVNDI 417 Query: 358 FAEQGVNIAAQYLQTSAQMGYVVIDIEA-DEDVAEKALQAMKAIPGTIRARLLY 410 + NI Q+ ++ ++ Y++ DI + D+ + + + I RLLY Sbjct: 418 LSNH--NIEKQFSDSNGEIAYLMADISSVDQSDIKDIYEQLNQTSAKISIRLLY 469 >UniRef50_D0NEX4 D-3-phosphoglycerate dehydrogenase n=1 Tax=Phytophthora infestans T30-4 RepID=D0NEX4_PHYIN Length = 466 Score = 390 bits (1003), Expect = e-107, Method: Compositional matrix adjust. Identities = 192/387 (49%), Positives = 267/387 (68%), Gaps = 7/387 (1%) Query: 4 VSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRT 63 V+ DKIK +L+E +H +A E GYT +E HK A+ E+L DAH +G+RS+T Sbjct: 57 VTYPLDKIKVVLLENIHPRAKEVFEREGYT-VETHKRAMSGEELARVGGDAHILGIRSKT 115 Query: 64 HLTEDVINAA----EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGE 119 L D N +L A+GCFCIGTNQV L +AA GIPVFNAPFSNTRSVAE + E Sbjct: 116 QLDPDFFNTVGWHEHRLWAVGCFCIGTNQVALPSAAATGIPVFNAPFSNTRSVAEKTLSE 175 Query: 120 LLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYF 179 ++ L R + + + H+G+W K A G+ E RG LGI+GYG IG+Q+ +LAE LGM V F Sbjct: 176 IIALHRKLFLRSTELHQGIWTKSATGAHEVRGTTLGIVGYGRIGSQVSVLAELLGMKVVF 235 Query: 180 YDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINAS 239 YD LPLGNA QV L +LL M+D V+LHVP P+TK M+ + I+ MK G+LL+N + Sbjct: 236 YDPVKCLPLGNARQVDTLEELLGMADAVTLHVPATPTTKKMINRETIAQMKDGALLVNNA 295 Query: 240 RGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQE 299 RGTV+DI A +A+ S +AG A+DVFP EPA N +PF +PL NV+LTPHIGGST+E Sbjct: 296 RGTVIDIDAAKEAVESGKIAGMAVDVFPKEPAKNGEPFDTPLRGLPNVILTPHIGGSTEE 355 Query: 300 AQENIGLEVAGKLIKYSDNGSTLSAVNFPEVS-LPL-HGGRRLMHIHENRPGVLTALNKI 357 AQ NI +EVA KL++Y ++GST ++ N PE+ LP+ + R++H+H+N PGVL+ ++ + Sbjct: 356 AQGNIAVEVASKLVRYINDGSTTTSTNTPEIDMLPIRNNSMRILHMHQNVPGVLSKIHSV 415 Query: 358 FAEQGVNIAAQYLQTSAQMGYVVIDIE 384 ++ G+N+ +QYLQ+ + GY+ +++E Sbjct: 416 LSDYGINVTSQYLQSDPRHGYIALEVE 442 >UniRef50_Q6A895 D-3-phosphoglycerate dehydrogenase n=4 Tax=Actinomycetales RepID=Q6A895_PROAC Length = 417 Score = 385 bits (990), Expect = e-105, Method: Compositional matrix adjust. Identities = 200/401 (49%), Positives = 278/401 (69%), Gaps = 7/401 (1%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K LL+E +H +A+ +L+ AGY +E ALD++ L ++ +G+RSRT +T V+ Sbjct: 22 MKALLLENIHDEAVRTLKKAGY-EVERVSEALDEDDLISALDGVDLLGIRSRTRVTRRVV 80 Query: 71 NAA-EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 A +KL A+G FCIGTNQ+DLDA A+ G+P FNAP+SNTRSV ELV+ E++ L R + + Sbjct: 81 EACGDKLHAVGAFCIGTNQMDLDALAEAGVPAFNAPYSNTRSVVELVMAEIIALARRLGD 140 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 N + H GVW K A GS E RG++LGIIGYG+IG QL ++AE++GM V+FYDI + LP+G Sbjct: 141 RNTQMHNGVWRKSAIGSHEIRGRRLGIIGYGNIGQQLSVVAEAMGMQVFFYDIADVLPMG 200 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 NA + + +LL + VSLH+ PS +++G +E ++M+P SL +N SRG VVDI AL Sbjct: 201 NAHKCDSMEELLGSVETVSLHIDGRPSNTDLIGDREFAMMRPRSLFLNLSRGKVVDINAL 260 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 D L + H+AGA +DV+P EPA+ +PF SPL E DNV+LTPHIGGSTQEAQ +IG VA Sbjct: 261 VDNLRTGHIAGAGVDVYPEEPASGKEPFISPLREMDNVILTPHIGGSTQEAQVDIGRYVA 320 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQY 369 GKLI Y DNG+T +VN PE++ G R+ H+H N PGV+ LN++ A+QG N+ Q Sbjct: 321 GKLIDYVDNGATGMSVNIPEITPSPRTGARIGHLHRNVPGVMATLNRLVADQGGNVTYQA 380 Query: 370 LQTSAQMGYVVIDI-EADEDVAEKALQAMKAIPGTIRARLL 409 L T ++GY ++DI E D + L + + GTIRAR+L Sbjct: 381 LATKGELGYCILDIAETDSGL----LANVTVLEGTIRARIL 417 >UniRef50_C7R3H8 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=19 Tax=Bacteria RepID=C7R3H8_JONDD Length = 416 Score = 384 bits (986), Expect = e-105, Method: Compositional matrix adjust. Identities = 206/400 (51%), Positives = 261/400 (65%), Gaps = 4/400 (1%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K LL+E VH A+E L + GY I GALD+ +L E+++ H +G+RS+T +T VI Sbjct: 14 LKALLLENVHPTAVEILSSHGYEVIT-RSGALDEAELIEALQGVHLLGIRSKTQVTRQVI 72 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 + A L+AIG FCIGTNQ+DL AAA+RG+ VFNAPFSNTRSV E+ I E++ L R +PE Sbjct: 73 DHAPDLIAIGAFCIGTNQIDLGAAAERGVGVFNAPFSNTRSVVEMAISEMISLTRRLPER 132 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 N H GVW+K A GS E RGK LGIIGYG+IGTQL +LAE+LGM V FYD KL LGN Sbjct: 133 NKAMHDGVWDKTADGSHEIRGKTLGIIGYGNIGTQLSVLAENLGMSVIFYDTAEKLALGN 192 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 A + L +LL +DVV++HV P + GA++ + MK G++ +N SRG V+D AL Sbjct: 193 ARRATTLEELLGAADVVTIHVDGRPGNAGLFGAEQFAAMKRGAIFLNLSRGFVMDNEALR 252 Query: 251 DALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAG 310 DA+ S H+AGAA+DVFPTEP D F S L NV+LTPHIGGST EAQE+IG VA Sbjct: 253 DAIMSGHVAGAAVDVFPTEPKKRGDAFDSELRGLANVILTPHIGGSTLEAQESIGEFVAN 312 Query: 311 KLIKYSDNGSTLSAVNFPEVSLPLHGG-RRLMHIHENRPGVLTALNKIFAEQGVNIAAQY 369 KL Y GST +VN P ++L G R+ +H N PGVL A+N A VNI Q Sbjct: 313 KLRDYVRTGSTTLSVNLPNLALETTGSITRIAFLHRNTPGVLAAVNNALATHNVNIDGQL 372 Query: 370 LQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 L T + GYVV D A V + L A+K I IR R++ Sbjct: 373 LATRGEFGYVVTD--AGSSVDPEVLNALKDIDQYIRIRVM 410 >UniRef50_C5DTI9 ZYRO0C08932p n=1 Tax=Zygosaccharomyces rouxii RepID=C5DTI9_ZYGRO Length = 469 Score = 382 bits (980), Expect = e-104, Method: Compositional matrix adjust. Identities = 195/414 (47%), Positives = 266/414 (64%), Gaps = 17/414 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K LL+E V+ A+ GY +EFHK +L +E+L E I+D H IG+RS+T LT +V+ Sbjct: 59 MKILLLENVNATAVSIFEDQGY-QVEFHKSSLPEEELIEKIKDVHAIGIRSKTKLTANVL 117 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A+ LV+IGCFCIGTNQVDL A GI VFN+PFSN+RSVAEL+IGE++ L R + + Sbjct: 118 KHAKNLVSIGCFCIGTNQVDLKYATHAGIAVFNSPFSNSRSVAELIIGEIISLARQLGDR 177 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + + H G WNK++ +E RGK LGIIGYGHIG+QL +LAE++GM+V +YD + LG Sbjct: 178 SIELHTGAWNKVSNRCWEVRGKTLGIIGYGHIGSQLSVLAEAMGMHVLYYDTVTIMALGT 237 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 A QV L +LLN SD ++ HVP P TKNM+ A + + MK G+ ++NASRGTVVDIPAL Sbjct: 238 ARQVPTLDELLNNSDFITCHVPATPETKNMLSAPQFAAMKEGAYVLNASRGTVVDIPALI 297 Query: 251 DALASKHLAGAAIDVFPTEPATNS--------DPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 A +AGAA+DV+P+EP N +P+ S L N++LTPHIGGST+EAQ Sbjct: 298 QAFKVGKIAGAALDVYPSEPGKNGAGAFSDDLNPWASELISLPNIILTPHIGGSTEEAQS 357 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVNFPEVSL-----PLHGGRRLMHIHENRPGVLTALNKI 357 IG+EVA L KY + G+++ +VNFPEVSL R+++IH N PGVL +N I Sbjct: 358 AIGVEVAASLTKYINEGTSVGSVNFPEVSLRSLDYDQENTVRVLYIHHNVPGVLKTVNNI 417 Query: 358 FAEQGVNIAAQYLQTSAQMGYVVIDIE-ADEDVAEKALQAMKAIPGTIRARLLY 410 + NI Q+ + + Y++ DI D+ + + I RLLY Sbjct: 418 LSNH--NIEKQFSDSKGDIAYLMADISNVDQSDIKNVYDELNQTDAKISIRLLY 469 >UniRef50_A6G5P3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6G5P3_9DELT Length = 405 Score = 367 bits (941), Expect = e-100, Method: Compositional matrix adjust. Identities = 189/383 (49%), Positives = 258/383 (67%), Gaps = 12/383 (3%) Query: 15 LVEGVHQKALESLRAAGYTNIEFHK--GALDDEQLKESIRDAH-----FIGLRSRTHLTE 67 + E +H A ++ A +++ H+ L E++ E++ IG+RS+T + Sbjct: 1 MSESIHASASDAFERA---DVQVHRTSAGLGPEEIIEALNGLPGDGPVMIGVRSKTKVRA 57 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 + A +L A+G FCIGT+Q+DL+ AA+ G+ VFNAPFSNTRSVAELVI E++ L R + Sbjct: 58 PIFEAVPRLAAVGAFCIGTDQIDLEVAAQSGVAVFNAPFSNTRSVAELVIAEIVCLSRQL 117 Query: 128 PEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP 187 E + AH G W K A G+ E RGK LGIIGYGHIG+QL +LAE++G+ V ++DI NKLP Sbjct: 118 FERSWAAHEGRWRKDAKGAHEVRGKTLGIIGYGHIGSQLSVLAEAMGLRVRYHDIVNKLP 177 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 LGNA+ + L LL SD VSLHVP P T+NM GA E++ MKPG+ LINASRGTVVDI Sbjct: 178 LGNASASESLDALLAGSDFVSLHVPNTPQTRNMFGAAELAKMKPGAYLINASRGTVVDIE 237 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL +L S H+AGAA+DV+P EP + +DPF SPL V+LTPHIGGSTQEAQ NIG+E Sbjct: 238 ALRASLESGHVAGAALDVYPKEPKSTADPFESPLQGLRQVILTPHIGGSTQEAQANIGVE 297 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVSLP-LHGGR-RLMHIHENRPGVLTALNKIFAEQGVNI 365 V+ L Y+ G T + P + P + GR RL++IH + PGVLT+ N+ ++ G+NI Sbjct: 298 VSEALAAYTRFGRTTGCITLPAIDAPAISPGRSRLLNIHRDVPGVLTSANQRVSDAGLNI 357 Query: 366 AAQYLQTSAQMGYVVIDIEADED 388 Q L+T A +G +++D++A D Sbjct: 358 TGQRLETQAGVGLLLMDVDAKSD 380 >UniRef50_C2BW43 Phosphoglycerate dehydrogenase n=1 Tax=Mobiluncus curtisii ATCC 43063 RepID=C2BW43_9ACTO Length = 413 Score = 340 bits (871), Expect = 7e-92, Method: Compositional matrix adjust. Identities = 182/400 (45%), Positives = 252/400 (63%), Gaps = 5/400 (1%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K LL+E H+ A + A ++ G+LD+ L ++++ +G+RS+T+L++ V + Sbjct: 3 KILLLENPHEVANKVFSDAN-VQVDRIDGSLDENDLIKALQGYQMVGIRSKTNLSKRVFD 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 LV G F IGTNQ+DL AAK G+ VFNAP+SNTRSVAEL I E++ L R +P N Sbjct: 62 ECPDLVCAGTFTIGTNQIDLKEAAKHGVAVFNAPYSNTRSVAELAIAEIIALARQLPVRN 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 A W K A GS E RGK LGIIGY GTQL ILAE++GM V FYD+ KLP+GNA Sbjct: 122 AHLQNADWQKTAKGSHEVRGKTLGIIGYSSTGTQLSILAEAMGMKVQFYDLAKKLPIGNA 181 Query: 192 TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCD 251 Q L + L +D VSLHV S +NM +++ MKPG+ L+N SRG VV++ L + Sbjct: 182 KQCNSLEEALQGADFVSLHVDGRASNENMFTKVQMNQMKPGAKLLNLSRGFVVNLDDLAE 241 Query: 252 ALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGK 311 AL S + G AIDVFP EP N + F SP+ +N +LTPHIGGST EAQE+IG VAGK Sbjct: 242 ALDSGQIGGCAIDVFPDEPRKNGEEFHSPIMGKENTILTPHIGGSTLEAQEDIGWFVAGK 301 Query: 312 LIKYSDNGSTLSAVNFPEVSL-PLHGGR-RLMHIHENRPGVLTALNKIFAEQGVNIAAQY 369 + Y +G T+ +VN P +SL P + R+ IH+N PGV+ +N++F++ GVNI Q Sbjct: 302 ICTYLQSGETVMSVNMPNLSLEPTDNTKYRITLIHKNVPGVMAKINQLFSDAGVNIEGQV 361 Query: 370 LQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 L T+ ++GYV+ DI + ++ + AL + T+ R + Sbjct: 362 LGTNGEVGYVIGDISS--EMPKAALDEIAKFDSTLSVRCI 399 >UniRef50_A9V4F4 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V4F4_MONBE Length = 368 Score = 302 bits (773), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 174/405 (42%), Positives = 242/405 (59%), Gaps = 65/405 (16%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 I LL+E + +A+++ +A G+T + K +E+L E+I+D H IG+RS+T L V+ Sbjct: 12 INVLLMEKISTEAVKTFQAEGFTVRQAVK--YSEEELVEAIKDVHIIGVRSKTKLPARVL 69 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +AA KL AIGCFCIGT+Q DL AA +GIPVFNAP++NTRSV+ELVI E+++L R + Sbjct: 70 DAATKLTAIGCFCIGTDQTDLKHAASKGIPVFNAPYANTRSVSELVIAEIIMLARQAGDR 129 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + + H+G WNK + G +E RGK LGIIGYGH+G+QL +LAESLG+ + Sbjct: 130 SMEIHQGEWNKKSDGCYEVRGKTLGIIGYGHVGSQLSVLAESLGLKM------------- 176 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 K GS LINA+RG+ VDI + Sbjct: 177 ---------------------------------------KTGSYLINAARGSCVDIEHVA 197 Query: 251 DALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAG 310 AL S HLAGAAIDV+P EPA ++ + + L N +LTPHIGGST+EAQ +IG EVA Sbjct: 198 AALRSGHLAGAAIDVYPKEPAGHTKEWVNVLQGCPNTILTPHIGGSTEEAQASIGREVAT 257 Query: 311 KLIKYSDNGSTLSAVNFPEVSLPLH---GGRRLMHIHENRPGVLTALNKIFAEQGVNIAA 367 K+I Y D GSTL AVN PE+++ G R++ H+N PGVL + NI + Sbjct: 258 KIIAYMDRGSTLGAVNVPEINISARLDEGHSRVVSFHQNTPGVLR--DINNIISIANIKS 315 Query: 368 QYLQTSAQMGYVVIDIE--ADEDVAEKALQAMKAIPGTIRARLLY 410 Q L T+ ++GY+V+D+E + +V EK ++ +P IR RLL+ Sbjct: 316 QQLLTNDEVGYLVVDLETVSISEVKEK----LEQVPHNIRLRLLF 356 >UniRef50_A4R1I1 Putative uncharacterized protein n=1 Tax=Magnaporthe grisea RepID=A4R1I1_MAGGR Length = 421 Score = 292 bits (747), Expect = 2e-77, Method: Compositional matrix adjust. Identities = 155/329 (47%), Positives = 205/329 (62%), Gaps = 43/329 (13%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 IK LL+E V+Q + LR GY +E HK +L ++QL E IR H IG+RS+T L+E V+ Sbjct: 63 IKILLLENVNQSGQDILREQGY-QVEAHKTSLPEDQLIEKIRSVHVIGIRSKTRLSEKVL 121 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A+ L+ +GCFCIGTNQVDL+ AA+ GI VFN+PF+N+RSVAELVI E++ L R + + Sbjct: 122 REAKNLLVVGCFCIGTNQVDLEYAARHGIAVFNSPFANSRSVAELVIAEIITLARQLGDR 181 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + + HRG WNK S+ L + LG Sbjct: 182 SNEMHRGTWNK----SYTTTSSTL-------------------------------MALGK 206 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 A QV L DLL SD V+LHVP P TKNM+ +++ MK GS LINASRGTVVDIPAL Sbjct: 207 AVQVSKLEDLLRESDFVTLHVPATPETKNMISNAQLNQMKTGSYLINASRGTVVDIPALI 266 Query: 251 DALASKHLAGAAIDVFPTEPATNSDPFTSPLCEF-------DNVLLTPHIGGSTQEAQEN 303 +A+ + +AGAA+DV+P EPA N D F + L + +N++LTPHIGGST+EAQ Sbjct: 267 NAMRAGKIAGAALDVYPNEPAANGDYFNNQLNTWGEDLRTLNNIILTPHIGGSTEEAQRA 326 Query: 304 IGLEVAGKLIKYSDNGSTLSAVNFPEVSL 332 IG+EVA L++Y + G TL +VN PE +L Sbjct: 327 IGVEVADALVRYINQGVTLGSVNLPECNL 355 >UniRef50_A3DM01 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=5 Tax=Archaea RepID=A3DM01_STAMF Length = 311 Score = 225 bits (573), Expect = 2e-57, Method: Compositional matrix adjust. Identities = 132/315 (41%), Positives = 190/315 (60%), Gaps = 12/315 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ +H+KALE LR+AG+ + ++ +++L E I+D I +RS+ ++ VI Sbjct: 2 VKILVAAPLHEKALEKLRSAGFQIV--YEEYPSEDRLVELIKDVEAIIVRSKPKVSRRVI 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AAEKL I +G + +DLDAA ++GI VFNAP + T+SVAEL IG ++ +LR + A Sbjct: 60 EAAEKLKVIARAGVGLDNIDLDAANEKGIQVFNAPAAPTQSVAELAIGLMIDVLRKIAFA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILA-ESLGMYVYFYDIENKLPLG 189 + K GVW K E RG LGIIG G IGT + +A GM + +YD+ + P Sbjct: 120 DRKMREGVWAKKQCLGHELRGIVLGIIGMGRIGTAVARIAYHGFGMKIIYYDV-RRCPKD 178 Query: 190 NATQVQ----HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 ++ L LL +D+VS+HVP PSTK+++ +++ LMK ++LIN +RG VVD Sbjct: 179 VEKELDAKCVDLETLLKTADIVSIHVPLVPSTKHLINEEKLRLMKKSAILINTARGGVVD 238 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL AL +AGA +DVF EP P PL + DNV+LTPHIG +T EAQE G Sbjct: 239 TDALVKALKEGWIAGAGLDVFEEEPL----PPNHPLTKLDNVVLTPHIGANTVEAQERAG 294 Query: 306 LEVAGKLIKYSDNGS 320 +EV K+I++ S Sbjct: 295 IEVVEKIIEFFKGSS 309 >UniRef50_Q1V300 D-3-phosphoglycerate dehydrogenase (Fragment) n=3 Tax=Gammaproteobacteria RepID=Q1V300_VIBAL Length = 166 Score = 214 bits (545), Expect = 5e-54, Method: Compositional matrix adjust. Identities = 99/136 (72%), Positives = 123/136 (90%) Query: 1 MAKVSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLR 60 MAKVSLEK+KIK LL+EG+H ++E L+AAGYTNIE+HKG+L +E+L E+++D HFIG+R Sbjct: 1 MAKVSLEKEKIKILLLEGLHPSSVEVLQAAGYTNIEYHKGSLPEEELIEAVKDVHFIGIR 60 Query: 61 SRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGEL 120 SRT+L+E+VINAA KLVAIGCFCIGTNQV+LDAAAKRGIPVFNAPFSNTRSVAELV+G++ Sbjct: 61 SRTNLSEEVINAANKLVAIGCFCIGTNQVNLDAAAKRGIPVFNAPFSNTRSVAELVLGQI 120 Query: 121 LLLLRGVPEANAKAHR 136 LLL+RG+PE + R Sbjct: 121 LLLVRGIPERCSCTSR 136 >UniRef50_A5D6D4 Phosphoglycerate dehydrogenase and related dehydrogenases n=3 Tax=Firmicutes RepID=A5D6D4_PELTS Length = 526 Score = 207 bits (526), Expect = 8e-52, Method: Compositional matrix adjust. Identities = 127/324 (39%), Positives = 187/324 (57%), Gaps = 10/324 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+++GV ++ L++LR ++ K + +++L +I D I +RS T +T +I Sbjct: 1 MKVLVLDGVEEEGLKALRQEPGIQVDV-KDKMSEDELVAAIGDYDGIIVRSATKVTARII 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A +L +G +G + +D+ AA RGI V NAP NT +VAE I +L L R +P+A Sbjct: 60 EKAARLKVVGRAGVGVDNIDVPAATARGILVVNAPEGNTLAVAEHTIAMMLSLARNIPQA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI---ENKLP 187 NA G W+K + E RGK LG+IG G IG+ + A+ + M V YD E K Sbjct: 120 NASLRAGKWDKKSFMGVELRGKVLGVIGLGRIGSAVAKRAQGMEMKVVAYDPYINEEKAG 179 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 L T + L +LL +D +++H+P +K M+G K SLMK G +IN +RG VVD Sbjct: 180 LLGVTLLS-LEELLKQADFITVHLPLTRESKYMLGEKAFSLMKDGVRIINCARGGVVDEQ 238 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL +A+ S +AGAA+DVF EP T+ SPL EF N + TPH+G STQEAQ ++ + Sbjct: 239 ALYNAMKSGKVAGAALDVFEKEPNTD-----SPLFEFKNFIATPHLGASTQEAQLSVATD 293 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVS 331 VA +++ +AVN P VS Sbjct: 294 VAREVVAALKGELVKNAVNIPSVS 317 >UniRef50_A9WCW3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A9WCW3_CHLAA Length = 525 Score = 205 bits (521), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 130/324 (40%), Positives = 181/324 (55%), Gaps = 13/324 (4%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ E + + L LR AG ++ LD L I + + +RS T +T +VI Sbjct: 3 RILVTEKIAAEGLAVLRQAGTVDVRLD---LDKPTLISIIGEYDALVVRSATKVTAEVIA 59 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A E+L IG G + +D++AA +RGI V NAP SN +VAEL IG L+ L R +P+A+ Sbjct: 60 AGERLRVIGRAGTGVDNIDVEAATRRGIIVVNAPASNNVAVAELTIGLLISLARRIPQAH 119 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD----IENKLP 187 A G W + +E RGK LG++G G IG+++ A SL M V YD + Sbjct: 120 ASLQSGRWARNDFVGWEVRGKTLGLVGLGRIGSEVARRARSLEMEVLAYDPVVSFDRAEQ 179 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 LG + L +L+ SDV+SLHVP ST+N+ + I MK G+ LINASRG +VD Sbjct: 180 LG--VSLVTLDELVQRSDVISLHVPLIESTRNLFDQQRIMQMKRGAYLINASRGGIVDEV 237 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL +AL S HL GAA+DV+ EP P SPL ++ PHIG ST EAQ + G E Sbjct: 238 ALVEALNSGHLGGAALDVYNQEPL----PADSPLLGHPKIITVPHIGASTTEAQLSAGTE 293 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVS 331 +A ++ + G+ AVN P V+ Sbjct: 294 MAEGVVTALNGGTPRYAVNAPFVA 317 >UniRef50_D2RHI0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RHI0_ARCPR Length = 525 Score = 204 bits (520), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 117/324 (36%), Positives = 185/324 (57%), Gaps = 10/324 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFH-KGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 +K L+ + + ++A++ ++ G +E K + E+L E I+D + +RSRT +T DV Sbjct: 1 MKVLVADPIAEEAIDFMKKNG---LEVDVKTDISHEELLEVIQDYDALIVRSRTRVTRDV 57 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I+ A+KL IG +G + +D+D A ++GI V NAP N+ S AE IG +L + R +P+ Sbjct: 58 IDRAKKLKIIGRAGVGVDNIDVDYATEKGIVVVNAPGGNSVSAAEHTIGLILSIARKIPQ 117 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IENKLP 187 A+ G W + E RGK LGI+G G IG ++ M + YD + + Sbjct: 118 ADRSVKEGKWERKKFVGIELRGKTLGIVGLGRIGYEVAKRMRCFEMNILAYDPYVSEERA 177 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 ++ L +LL SD++++HVP+ T+ M+ KE +MK G +INA+RG +VD Sbjct: 178 KSVGAKLVSLEELLRNSDIITIHVPKTKETEKMISYKEFEIMKDGVYIINAARGGIVDEK 237 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL DAL S +AGAA+DV+ EP + PL + +NV+ TPHIG ST+EAQ +G+ Sbjct: 238 ALYDALVSGKVAGAALDVYEKEPPDKDN----PLLKLENVVTTPHIGASTREAQMMVGMT 293 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVS 331 VA ++ + +AVN P ++ Sbjct: 294 VAEDIVNFFKGLPVKNAVNLPSIA 317 >UniRef50_Q1AXS3 D-3-phosphoglycerate dehydrogenase n=2 Tax=Actinobacteria (class) RepID=Q1AXS3_RUBXD Length = 527 Score = 202 bits (514), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 122/321 (38%), Positives = 181/321 (56%), Gaps = 11/321 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 ++ L+ E + ++ +E LR ++ L +L E I + + +RS T +T +VI Sbjct: 1 MRVLVTEKLAERGVELLRREFEVDVLL---GLSPGELLERIGEYDGLIVRSATKVTAEVI 57 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA +L AIG IG + +D++AA KRGI V NAP SNT + AE +G +L + R +P A Sbjct: 58 EAAGRLKAIGRAGIGVDNIDIEAATKRGILVANAPESNTVAAAEHTLGLMLAVARRIPAA 117 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD---IENKLP 187 +A RG WN+ A E K LG++G GH+G+ + A +GM V YD E ++ Sbjct: 118 DASLRRGEWNRAAFKGVEVAEKTLGLVGLGHVGSIVARGALGMGMRVLAYDPYVSEERMR 177 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 N + L ++ +D VSLHVP P T M+G +E++ MKP + LIN +RG +VD Sbjct: 178 SMNVERAGSLEEIFEEADFVSLHVPRTPQTTGMVGEEELARMKPTAYLINVARGGIVDET 237 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL +AL +AGAA+DVF EP T+ SPL NV++TPH+G ST EAQ+ G+ Sbjct: 238 ALYNALKQGEIAGAALDVFAEEPTTD-----SPLFALPNVVVTPHLGASTAEAQDRAGVT 292 Query: 308 VAGKLIKYSDNGSTLSAVNFP 328 A ++ + A+N P Sbjct: 293 AAEQVAAALRGEVPIHAINAP 313 >UniRef50_B0TAQ8 D-3-phosphoglycerate dehydrogenase n=4 Tax=Clostridia RepID=B0TAQ8_HELMI Length = 526 Score = 199 bits (507), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 113/324 (34%), Positives = 183/324 (56%), Gaps = 12/324 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 ++ L+ + + QK ++ L +AG ++ K L ++Q+ E I + + +RS T +T+ +I Sbjct: 1 MRVLVCDPISQKGIDVLTSAGDVAVDV-KLKLTEDQIVEIIAEYDAVVVRSETKITKRII 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA++L AIG +G + +D++AA ++GI V NAP NT + AEL + +L + R V A Sbjct: 60 EAADRLKAIGRAGVGVDNIDVEAATRKGIVVVNAPEGNTIAAAELTVAHILAIARNVGSA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD----IENKL 186 N G W++ E +GK LGI+G G IG+++ A + M V YD +E Sbjct: 120 NLSLKGGKWDRSKYTGIELKGKTLGILGLGKIGSEVAKRARAFDMTVIAYDPYASVEKAK 179 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 LG V L + SD +++H+P+ T M+ A + ++MK G ++N +RG ++D Sbjct: 180 SLG--VTVTDLETVFRQSDFITVHMPKTKDTYRMISAAQFAIMKEGVRIVNCARGGIIDE 237 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL DA+ S +A A +DVF EP T+ SPL D V TPH+G ST+EAQ N+ + Sbjct: 238 QALYDAIQSGKVAAAGLDVFEKEPCTD-----SPLFALDQVTATPHLGASTKEAQVNVAI 292 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEV 330 +VA +++ + +AVN P V Sbjct: 293 DVAYDILRVLRGEAVSAAVNIPAV 316 >UniRef50_A2STQ1 D-3-phosphoglycerate dehydrogenase n=5 Tax=cellular organisms RepID=A2STQ1_METLZ Length = 527 Score = 197 bits (502), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 112/296 (37%), Positives = 174/296 (58%), Gaps = 7/296 (2%) Query: 38 HKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKR 97 K L +++L + I + + +RS T +T +I AA+K+ IG +G + +D +AA K+ Sbjct: 27 EKADLSEDELVKIIGEYDALIVRSGTQVTARIIEAADKMKYIGRAGVGVDNIDCEAATKK 86 Query: 98 GIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGII 157 GI V NAP NT + E I ++ + R +P+A+A +G W + E GK LG++ Sbjct: 87 GIIVSNAPEGNTLAATEHTIAMMMAMARNIPQASASLKKGEWKRSKFMGNEMNGKVLGVV 146 Query: 158 GYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLS--DLLNMSDVVSLHVPENP 215 G+G IG ++ A++L M V YD +G A V+ +S +L +DV+++H P P Sbjct: 147 GFGRIGREVAKRAQALQMTVIAYDPFIPAEVGAAMGVEMMSVAELFTKADVITVHTPLIP 206 Query: 216 STKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSD 275 ST +++ + I+ MK G +IN +RG ++D L DA+ S +AGAA+DVF TEP Sbjct: 207 STTHLVNKESIATMKTGVRMINCARGGIIDEKDLYDAIVSGKVAGAALDVFETEP----- 261 Query: 276 PFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVS 331 P SPL + D+V++TPH+G ST EAQ+N+ + VA + I GS SAVN P V+ Sbjct: 262 PTESPLLKLDSVIVTPHLGASTVEAQKNVAISVAHQCIDVLKGGSAKSAVNAPLVT 317 >UniRef50_O27051 D-3-phosphoglycerate dehydrogenase n=16 Tax=Archaea RepID=SERA_METTH Length = 525 Score = 197 bits (500), Expect = 7e-49, Method: Compositional matrix adjust. Identities = 114/286 (39%), Positives = 161/286 (56%), Gaps = 7/286 (2%) Query: 45 EQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNA 104 E+L ++I+D I +RSRT +T +VI AA +L I +G + VD+ AA RGI V NA Sbjct: 35 EELLDAIKDFDAIVVRSRTKVTREVIEAAPRLKIIARAGVGVDNVDVKAATDRGIMVINA 94 Query: 105 PFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGT 164 P S + +VAE IG +L L R + A+ G W K E GK LGIIG G IG+ Sbjct: 95 PESTSITVAEHSIGLMLALARKIAIADRSVKEGKWEKNRFMGIELNGKTLGIIGMGRIGS 154 Query: 165 QLGILAESLGMYVYFYD--IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMG 222 Q+ + ++ GM + YD I + V L LL SD+V++HVP P T++++ Sbjct: 155 QVVVRTKAFGMDIMVYDPYISKEAAEEMGVTVTDLETLLRESDIVTIHVPLTPETRHLIS 214 Query: 223 AKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLC 282 E LMK + ++N +RG ++D AL AL +AGAA+DVF EP P SPL Sbjct: 215 EDEFKLMKDTAFIVNCARGGIIDEDALYRALKDGEIAGAALDVFEEEP-----PEGSPLL 269 Query: 283 EFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFP 328 E +NV+LTPHIG ST EAQ + + VA ++ G+ + +N P Sbjct: 270 ELENVVLTPHIGASTSEAQRDAAIIVANEIKTVFQGGAPRNVLNMP 315 >UniRef50_C8WVY8 D-3-phosphoglycerate dehydrogenase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WVY8_ALIAD Length = 529 Score = 197 bits (500), Expect = 7e-49, Method: Compositional matrix adjust. Identities = 121/327 (37%), Positives = 180/327 (55%), Gaps = 17/327 (5%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + Q ++ L + DE LKE+I DA + +RS+T +T DVI Sbjct: 4 KILVTDDISQAGIDILSGLQGAEVVVRTNLAPDE-LKEAIADADALVVRSQTRVTRDVIE 62 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 +A+KL IG +G + +DL+AA +RGI V NAP NT + AE ++ L R +P A+ Sbjct: 63 SAKKLKVIGRAGVGVDNIDLEAATRRGILVINAPDGNTIAAAEHTFAMMISLARHIPAAH 122 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 +G WN+ E RGK L ++G G IGT++ A++ GM V YD P Sbjct: 123 RDLLQGNWNRKKWIGVELRGKTLAVLGMGRIGTEVAKRAKAFGMTVLGYD-----PFLTE 177 Query: 192 TQVQHL----SDL---LNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + Q L DL + +D +++H P T +M+ A I+ MK G +IN +RG ++ Sbjct: 178 ERAQSLGVKRCDLDTAIREADFITVHTPLTKETHHMIDAGRIAQMKEGVRIINCARGGII 237 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL +AL + +AGAAIDVF EP P PL NV+LTPH+G ST EAQEN+ Sbjct: 238 DEVALAEALEAGRVAGAAIDVFEQEPL----PMDHPLRRCPNVVLTPHLGASTVEAQENV 293 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEVS 331 ++VA ++++ + + AVN P +S Sbjct: 294 AIQVAEEIVQVLRDDTFEHAVNLPSLS 320 >UniRef50_A5FRL7 D-3-phosphoglycerate dehydrogenase n=5 Tax=Dehalococcoides RepID=A5FRL7_DEHSB Length = 526 Score = 196 bits (498), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 125/330 (37%), Positives = 177/330 (53%), Gaps = 13/330 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + L L+ ++ K L E+L I + + +RS+T +T D+IN Sbjct: 3 KVLVSDALSATGLAPLKEIAQVDV---KTGLKPEELISIIGEYDALLVRSQTQVTADIIN 59 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A +KL IG +G + +DL AA GI V NAP NT S E + +L + R +P AN Sbjct: 60 AGKKLQVIGRAGVGVDNIDLKAATGNGIIVVNAPTGNTISATEHTLALMLAMARHIPRAN 119 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 A G W + E +GK LGI+G G+IG+++ A +L M V YD + Sbjct: 120 ASLKSGQWKRNEFVGSELKGKTLGIVGLGNIGSEIAKRALALEMRVIGYDPFISMERAKK 179 Query: 192 TQVQHL--SDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 QV+ L DLL +D ++LHVP TK ++G KE+ +MKP LIN SRG ++D AL Sbjct: 180 LQVELLPFEDLLKQADFITLHVPMTGQTKGLIGPKELEMMKPTVRLINTSRGGIIDEEAL 239 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 A+ K + GAAIDVF EP T S F E DN+++TPH+G ST EAQE +V Sbjct: 240 AKAVKEKRIGGAAIDVFSKEPCTESCLF-----ECDNIIVTPHLGASTAEAQELATSDVV 294 Query: 310 GKLIKYSDNGSTLSAVNFPEV---SLPLHG 336 ++I + AVN P + SLP+ G Sbjct: 295 KQVIDVFEGRPARYAVNAPYISAESLPVVG 324 >UniRef50_A8A9G4 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=3 Tax=Archaea RepID=A8A9G4_IGNH4 Length = 308 Score = 195 bits (496), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 122/307 (39%), Positives = 171/307 (55%), Gaps = 10/307 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ + VH LE LR G +E + A E LKE I+ + +RSRT + +VI Sbjct: 3 RALVTDKVHPAGLELLREKGIEVVEDLE-AYKPEVLKERIKGFDVLIVRSRTKVRREVIE 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AA+KL I G + +DL+AA ++GI V NAP + +VAELVIG +++L R + Sbjct: 62 AADKLKVIARAGSGLDNIDLEAAKEKGIKVVNAPDALKNAVAELVIGMMVVLARRAHYSY 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI----ENKLP 187 K G W K+ FE GK LG++G+G IG ++ A++LGM V YD+ E Sbjct: 122 RKLLEGEWEKVMG--FELAGKTLGVVGFGRIGREVAKKAKALGMNVIAYDVVDLSETAKE 179 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 +G Q L +LL SDVVSLHVP T+NM+ I +MK G++LINA+RG V D Sbjct: 180 MG-VEFTQDLEELLRKSDVVSLHVPLTEQTRNMINRDRIKIMKDGAILINAARGEVADYS 238 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL +AL S L G +DV+P EP + + L T HIG T+EAQ LE Sbjct: 239 ALLEALESGKLWGVGLDVYPEEPPKSEELL--KLIRHPRTFATAHIGAQTEEAQRRTSLE 296 Query: 308 VAGKLIK 314 VA ++++ Sbjct: 297 VAQRILE 303 >UniRef50_A7IAB7 D-3-phosphoglycerate dehydrogenase n=11 Tax=cellular organisms RepID=A7IAB7_METB6 Length = 534 Score = 195 bits (495), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 111/294 (37%), Positives = 169/294 (57%), Gaps = 7/294 (2%) Query: 39 KGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRG 98 K L +++L I + + +RS T +T VI A +KL IG +G + VD+DAA ++G Sbjct: 29 KTDLKEDELCGVIGEYDALIVRSGTEVTAKVITAGKKLRFIGRAGVGVDNVDVDAATRQG 88 Query: 99 IPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIG 158 + V NAP NT + E + +L L R +P+ANA + W + E K LGI+G Sbjct: 89 VIVANAPEGNTLAATEHTMAMMLSLARNIPQANASLKKKEWKRSKFMGVELNEKTLGIVG 148 Query: 159 YGHIGTQLGILAESLGMYVYFYD--IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPS 216 +G IG ++ A ++ M YD I + +V L++L ++DV+++H P Sbjct: 149 FGRIGREVAKRANAMDMKCVAYDPFISKERAAQLGVRVMSLAELFTVADVITVHTPLIKE 208 Query: 217 TKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDP 276 TK+++ AK I+ MK G +IN +RG ++D AL DA+ S +AGAA+DVF TEP P Sbjct: 209 TKHVINAKSIATMKDGVRIINCARGGIIDEAALVDAIKSGKVAGAALDVFETEP-----P 263 Query: 277 FTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEV 330 SPL DNV++TPH+G ST EAQ+N+ ++VA + ++ + GS VN P V Sbjct: 264 LESPLLSLDNVIVTPHLGASTVEAQKNVAIQVAKQCVEVLNGGSAKYVVNAPIV 317 >UniRef50_A6UQN3 D-3-phosphoglycerate dehydrogenase n=4 Tax=Euryarchaeota RepID=A6UQN3_METVS Length = 523 Score = 195 bits (495), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 127/390 (32%), Positives = 214/390 (54%), Gaps = 28/390 (7%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ + +H+ A+E L+ AG +E G + E++K+ I+DA + +RS T +T+++I Sbjct: 2 LKILITDPLHESAIEILKEAG--EVEIATG-ISIEEIKQKIKDADALVVRSGTTVTKEII 58 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +A+E L I +G + VDLDAA ++G+ V NAP +++ SVAEL+ G +L R +P+A Sbjct: 59 DASENLKVIARAGVGVDNVDLDAATEKGVVVVNAPDASSISVAELMFGLMLSAARNIPQA 118 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IENKLPL 188 A +G W++ + E K LGI+G G IG Q+ A++ M + YD I + Sbjct: 119 TASLKKGEWDRKSFKGMEVYAKTLGIVGLGRIGQQVAKRAQAFEMNIVAYDPYIPENVAS 178 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 ++ + +L S+ ++LHVP TK+M+G + LMK +++IN +RG ++D A Sbjct: 179 ELGIKLLSVDELCAESEFITLHVPLTTKTKHMIGKTQFDLMKNNTIIINCARGGLIDENA 238 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L DA+ + A +DVF EP P +PL + ++ TPH G ST+EAQ + G V Sbjct: 239 LYDAINCGKVKAAGLDVFEEEP-----PTKNPLISLNGLIGTPHQGASTEEAQLSAGTIV 293 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 A + +K S + VN P V P ++LM P + + AE+ +++ Q Sbjct: 294 AEQTVKILKGESAENVVNLPMV--PTEKMKKLM------PYL------VLAEKMGSMSIQ 339 Query: 369 YLQTSAQMGYVVIDIEADEDVAEKALQAMK 398 YL S +++I D+A++ + +K Sbjct: 340 YLDNSID----IVEITYMGDLAKEKTEMLK 365 >UniRef50_UPI0001C430A3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Bacillus pseudofirmus OF4 RepID=UPI0001C430A3 Length = 540 Score = 193 bits (491), Expect = 9e-48, Method: Compositional matrix adjust. Identities = 106/284 (37%), Positives = 161/284 (56%), Gaps = 17/284 (5%) Query: 59 LRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIG 118 +RS T +TE+++ L + +G + +DLDAA K G+ V NAP NT S AE Sbjct: 62 VRSATKVTEELLQKMPNLKIVARAGVGVDNIDLDAATKHGVVVVNAPDGNTISTAEHTFA 121 Query: 119 ELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVY 178 + LLR +P+ANA G WN+ A E RGK LGI+G+G IGTQ+ A + M + Sbjct: 122 MISSLLRKIPQANASIKAGEWNRKAFQGSELRGKTLGIVGFGRIGTQIAKRARAFEMSLL 181 Query: 179 FYDIENKLPLGNATQVQH-------LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKP 231 +D P + + L D+L SD++++H P TK ++G + I+ K Sbjct: 182 VFD-----PFLTKARAEKIGVTPASLDDVLAQSDIITVHTPLTKETKGILGMENIAKTKQ 236 Query: 232 GSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTP 291 G LIN +RG ++D AL LA+ H+AGAA+DVF EPA + + L EFDNV+ TP Sbjct: 237 GVFLINCARGGIIDESALKHYLANGHIAGAALDVFEEEPAQDKE-----LLEFDNVIATP 291 Query: 292 HIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLH 335 HI ST+EAQ N+ +V+ ++I++ + +++N P +S ++ Sbjct: 292 HIAASTKEAQLNVASQVSEEVIRFLEGQPATNSINLPTLSKEIY 335 >UniRef50_B9L167 Phosphoglycerate dehydrogenase SerA n=2 Tax=Thermomicrobia (class) RepID=B9L167_THERP Length = 745 Score = 190 bits (483), Expect = 7e-47, Method: Compositional matrix adjust. Identities = 121/343 (35%), Positives = 184/343 (53%), Gaps = 14/343 (4%) Query: 7 EKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLT 66 + + + ++ + + Q+A E L A+ IE D L E++R+A + +RS T +T Sbjct: 198 QPRRRRIVVSDVIDQRARERL-ASEADVIEV--DGRDKPALYEALREADALIVRSETQVT 254 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 +++ A +L + G + +DL AA + GI V NAP +N S E + +L + R Sbjct: 255 RELLAHAPRLRVVARAGTGVDNIDLQAATEAGILVLNAPGANAVSAGEHTVALMLAIARN 314 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI---- 182 + +ANA H G W + F+ +GK +GI+G G +G+ + + + YD Sbjct: 315 LIDANATTHAGRWERKRFRPFDLKGKTIGIVGLGRVGSVVAQRLRAFECRLLGYDPYITR 374 Query: 183 ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 E LG + LL SD+V+ HVP P T++M+ A+ I+ MKPG+++IN +RG Sbjct: 375 ERFAQLG--VEPVDYETLLENSDIVTFHVPATPETRHMLDARAIARMKPGAIVINCARGE 432 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 VVD+ AL +AL S HLA A +DVFP EPA + SPL NV+LTPHIGGS++EA E Sbjct: 433 VVDVQALAEALKSGHLAAAGVDVFPEEPA-----YQSPLFGLPNVVLTPHIGGSSREALE 487 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHE 345 +G +A + +AVN P SL RRL + E Sbjct: 488 AVGEIIATTTLAALRGEIVPNAVNLPAASLHAPELRRLTRVAE 530 >UniRef50_Q1IVI0 D-3-phosphoglycerate dehydrogenase n=3 Tax=Acidobacteria RepID=Q1IVI0_ACIBL Length = 531 Score = 189 bits (480), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 111/324 (34%), Positives = 180/324 (55%), Gaps = 9/324 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K ++ E + + A++ + N+ EQL E ++ A + +RS + ++ Sbjct: 1 MKIVVAEKIAKAAIDLFKQDPTWNVVTPDQVAQKEQLLEQLKGADALIVRSAVFVDAAML 60 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A++L IG +G + ++L+AA ++GI V N P +N +VAE IG +L L R +P A Sbjct: 61 EHADQLRVIGRAGVGVDNIELEAATRKGIAVMNTPGANAIAVAEHTIGLMLALARFIPRA 120 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 H G W K + E RGK LGI+G G IG ++ A S GM + +D + + Sbjct: 121 TETMHAGKWEKKSLQGTELRGKTLGIVGLGRIGLEVARRAASFGMTLVAHDPYVSPAIAH 180 Query: 191 ATQVQHLSD---LLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 +++ L+D +L ++D ++LHV P T NM+ A ++ MK G ++N +RG ++D Sbjct: 181 DAKIR-LADRDEVLAVADYITLHVGLTPQTANMINATTLATMKKGVRIVNCARGELIDDA 239 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL +A+ S H+ GAA+DVF EP SP NV+LTPHIGGST EAQ+ +G++ Sbjct: 240 ALAEAVKSGHVGGAALDVFTEEPLK-----ASPYHGVPNVILTPHIGGSTAEAQDAVGVQ 294 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVS 331 +A ++ Y G +AVN P ++ Sbjct: 295 IAHQVRDYLQRGVVQNAVNMPSLT 318 >UniRef50_Q2G4V7 D-3-phosphoglycerate dehydrogenase n=146 Tax=cellular organisms RepID=Q2G4V7_NOVAD Length = 540 Score = 189 bits (480), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 113/291 (38%), Positives = 164/291 (56%), Gaps = 11/291 (3%) Query: 45 EQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNA 104 EQL I + + +RS T +T+ +++AA L IG IG + VD+ AA+ +G+ V N Sbjct: 48 EQLIARIGEYDGLAIRSSTKVTKAILDAATNLKVIGRAGIGVDNVDIPAASAQGVVVMNT 107 Query: 105 PFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGT 164 PF N+ + AE I + L R +PEANA+ G+W K E GK LG+IG G+IG+ Sbjct: 108 PFGNSITTAEHAIAMMFALARQIPEANAQTQAGLWPKNGFMGVEVTGKTLGLIGAGNIGS 167 Query: 165 QLGILAESLGMYVYFYD----IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNM 220 + A L M V +D E + +G + L LL +D ++LH P T+N+ Sbjct: 168 IVASRALGLKMKVVAFDPFLTPERAVEMG--VEKADLETLLAKADFITLHTPLTDQTRNI 225 Query: 221 MGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSP 280 + + I+ K G +IN +RG +VD AL DAL S H+AGAA+DVF TEPA S F +P Sbjct: 226 LSRENIAKCKKGVRIINCARGGLVDEAALKDALDSGHVAGAALDVFETEPAKESPLFGTP 285 Query: 281 LCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVS 331 N + TPH+G ST EAQ N+ L+VA ++ + G +A+N P +S Sbjct: 286 -----NFICTPHLGASTTEAQVNVALQVAEQMADFLVTGGVTNALNMPSLS 331 >UniRef50_B2IJN8 D-3-phosphoglycerate dehydrogenase n=6 Tax=Bacteria RepID=B2IJN8_BEII9 Length = 529 Score = 188 bits (478), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 114/293 (38%), Positives = 160/293 (54%), Gaps = 11/293 (3%) Query: 43 DDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVF 102 D ++L E I + +RS T +T+ ++ A L +G IG + VD+ AA +G+ V Sbjct: 35 DKDKLAEIIGQFDGLAIRSATKVTDKILEKATNLKVVGRAGIGVDNVDIPAATAKGVIVM 94 Query: 103 NAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHI 162 N PF N+ + AE I + L R +P A+A G W K E K LGIIG G+I Sbjct: 95 NTPFGNSITTAEHAIALMFALARQIPSADASTQAGKWEKNKFMGVEITAKVLGIIGCGNI 154 Query: 163 GTQLGILAESLGMYVYFYD----IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTK 218 G+ + L M V +D E L LG + L DLL +D ++LH P P TK Sbjct: 155 GSIVAERGVGLKMRVIAFDPFLTPERALDLG--VEKVELDDLLARADFITLHTPLTPQTK 212 Query: 219 NMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFT 278 N++ A+ ++ K G +IN +RG +VD AL L S H+AGAA DVF TEPA + F Sbjct: 213 NILSAENLAKTKKGVRVINCARGGLVDEEALRKLLDSGHVAGAAFDVFITEPAKENPLFG 272 Query: 279 SPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVS 331 P NV+ TPH+G ST EAQEN+ L+VA ++ Y G+ +AVNFP ++ Sbjct: 273 HP-----NVVCTPHLGASTSEAQENVALQVAEQMSDYLTRGAISNAVNFPSIT 320 >UniRef50_UPI0001C31769 D-3-phosphoglycerate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31769 Length = 541 Score = 187 bits (476), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 116/337 (34%), Positives = 182/337 (54%), Gaps = 22/337 (6%) Query: 4 VSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGA-LDDEQLKESIRDAHFIGLRSR 62 ++ E +++K L+ E + ++ LR + + GA DE+ + + + H I +RS Sbjct: 1 MTAETNRLKILVKEKLADSGVDLLR----EHFDVDLGADWSDEEFRSRLPEYHGILIRSA 56 Query: 63 THLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLL 122 T LTE+ I L IG +G N VD+ AA +RGI V NAP SN + AE + LL Sbjct: 57 TKLTEEYIALGTNLRVIGRAGVGVNNVDVPAATRRGIVVANAPQSNVVTAAEHTMALLLS 116 Query: 123 LLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI 182 L R VP+A+ W + G E K LG++G+G IG + A+ GM V +D Sbjct: 117 LARNVPQAHRSLTDHRWERSKFGGVEVYEKTLGVVGFGRIGQLVAERAKGFGMKVVAFD- 175 Query: 183 ENKLPLGNATQVQHL--------SDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSL 234 P A + + L +D+ ++D +++H+P P T+ + A+ + MK G Sbjct: 176 ----PFVGAERYRDLGVEKADTSADVYKVADFITIHLPVTPETQGWLNAEAFAQMKDGVR 231 Query: 235 LINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIG 294 ++N +RG +VD AL DAL S +AGAA+DVFP+EP T+ F + NV++TPH+G Sbjct: 232 IVNCARGELVDDAALKDALDSGKVAGAALDVFPSEPITDYPLFDG----YANVVVTPHLG 287 Query: 295 GSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVS 331 ST EAQ+ G++ A ++I G+ +AVN P ++ Sbjct: 288 ASTAEAQDRAGVQTAEQVIAALTGGTVTTAVNIPAIA 324 >UniRef50_A5G1V9 D-3-phosphoglycerate dehydrogenase n=3 Tax=Proteobacteria RepID=A5G1V9_ACICJ Length = 528 Score = 187 bits (476), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 115/297 (38%), Positives = 164/297 (55%), Gaps = 11/297 (3%) Query: 39 KGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRG 98 K L +L+E I + + +RS T +T ++++AA L IG IG + VD+ +A RG Sbjct: 28 KTGLAPAELREIIGEFDGLAIRSATKVTRELLDAATNLKVIGRAGIGVDNVDVKSATARG 87 Query: 99 IPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIG 158 + V N P+ N + AE IG + L R +PEA+A G W K E GK LG+IG Sbjct: 88 VVVMNTPYGNAITTAEHAIGLMFALARELPEASASTKAGKWEKNRFMGVELTGKTLGLIG 147 Query: 159 YGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQV----QHLSDLLNMSDVVSLHVPEN 214 G+IG+ + A L M V YD L AT + L +L +D ++LH P Sbjct: 148 AGNIGSIVADRALGLKMRVLAYD--PYLTEARATTLGVEKADLDTVLARADFITLHTPLT 205 Query: 215 PSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNS 274 T+N++ + I+ KPG +IN +RG +VD AL DAL S H+AGAA+DVF EPA Sbjct: 206 EQTRNILSRESIARTKPGVRIINCARGGLVDEAALYDALKSGHVAGAALDVFEVEPAKE- 264 Query: 275 DPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVS 331 SPL NV+ TPH+G +T EAQEN+ L+VA ++ + G+ +A+N VS Sbjct: 265 ----SPLFALPNVVCTPHLGAATTEAQENVALQVAEQISDFLLTGAVTNAINMASVS 317 Score = 46.2 bits (108), Expect = 0.002, Method: Compositional matrix adjust. Identities = 23/71 (32%), Positives = 44/71 (61%), Gaps = 1/71 (1%) Query: 337 GRRLMHI-HENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQ 395 GR ++++ + ++PG + + I AE+G+NIA +L + + G V I DE + + AL Sbjct: 453 GRHMLYVTNRDKPGFIAQCSAILAEKGINIATFHLGRTEKGGDAVCLISIDETLPDDALA 512 Query: 396 AMKAIPGTIRA 406 A++A+P ++A Sbjct: 513 AIRALPQVMQA 523 >UniRef50_B7KZ64 D-3-phosphoglycerate dehydrogenase n=16 Tax=cellular organisms RepID=B7KZ64_METC4 Length = 535 Score = 187 bits (475), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 116/331 (35%), Positives = 178/331 (53%), Gaps = 13/331 (3%) Query: 6 LEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKG-ALDDEQLKESIRDAHFIGLRSRTH 64 L + K K L+ + + A++ R G ++F G D E L I + +RS T Sbjct: 4 LTQTKPKVLITDALSDAAVQIFRDRGI-EVDFQPGLGKDKEALAAIIGQYDGLAIRSATK 62 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 +T+ ++ A +L IG IG + +D+ AA RG+ V N PF N+ + AE I + L Sbjct: 63 VTDKLLAQATRLKVIGRAGIGVDTIDVPAATARGVIVMNTPFGNSITTAEHAIALIFALA 122 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--- 181 R +P A+A G W K E K LG++G G+IG + A L + V YD Sbjct: 123 RQIPAADASTQAGKWEKNRFMGVELTAKTLGVVGCGNIGAVVADRAIGLKLKVIAYDPFL 182 Query: 182 -IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 E +G + L +LL +D+++LHVP T+N++ + ++ K G ++N +R Sbjct: 183 TPERAFEIG--VEKVELDELLARADIITLHVPLTDKTRNLLSEENLAKTKRGVRIVNCAR 240 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G +VD AL AL S H+AGAA+DVF TEPA + F P NV+ TPH+G +T EA Sbjct: 241 GGLVDEIALRAALESGHVAGAALDVFVTEPAIENPLFGHP-----NVICTPHLGAATSEA 295 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVNFPEVS 331 QEN+ L++A ++ Y +G+ +A+NFP +S Sbjct: 296 QENVALQIAEQMADYLLSGAITNAINFPSIS 326 >UniRef50_C6HZG9 D-3-phosphoglycerate dehydrogenase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HZG9_9BACT Length = 537 Score = 187 bits (474), Expect = 9e-46, Method: Compositional matrix adjust. Identities = 131/400 (32%), Positives = 202/400 (50%), Gaps = 37/400 (9%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGL--RSRTHLTE 67 KIK L+ + + ++ + + AG+ K L ++LK + AH+ GL RS T +T Sbjct: 6 KIKILVSDPISEEGINIFKNAGFEVTV--KAKLSPDELKAEL--AHYDGLVIRSGTKVTA 61 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 V+ A +L IG G + VDL AA RGI V N P NT + AE + ++ + R + Sbjct: 62 HVLEGATRLKVIGRAGAGLDNVDLPAATNRGIVVMNTPGGNTITTAEHTVSMMMSMARRI 121 Query: 128 PEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP 187 P+ANA G W K E K LGI+G G IG+ + +A+ L M V YD P Sbjct: 122 PQANASNRSGKWEKSKFMGIELAHKTLGILGMGKIGSHVAHVAQGLLMNVIAYD-----P 176 Query: 188 LGNATQVQH-------LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 A + +L +D++++H P P T N++ + I+ MK G ++N +R Sbjct: 177 FLTAESAARQGVTPVTVEELFAKADIITVHTPLTPETTNLISSASIAKMKKGVYIVNCAR 236 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G +V+ L AL S H+AGAA DVF EP + + PL + DN + TPHIG +T+EA Sbjct: 237 GGIVNEADLAKALESGHVAGAAFDVFAEEPPSPDN----PLLKLDNFISTPHIGAATKEA 292 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRL---MHIHENRPGVLT----- 352 QEN+ L VA +++ Y G A N P S+P R+ + E G+L+ Sbjct: 293 QENVALAVADQMVDYLAKGIIRYAANLP--SVPPEDAARVTPYQQLAEVMGGILSQIATE 350 Query: 353 ALNKI---FAEQGVNIAAQYLQTSAQMGYV--VIDIEADE 387 A +KI F+ + + Q + +A G + ++D+ +E Sbjct: 351 AFSKISVEFSGEAATLPTQIITIAALKGVLAPMLDVRVNE 390 >UniRef50_Q49YF7 D-3-phosphoglycerate dehydrogenase n=55 Tax=Bacillales RepID=Q49YF7_STAS1 Length = 538 Score = 186 bits (473), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 105/293 (35%), Positives = 163/293 (55%), Gaps = 9/293 (3%) Query: 42 LDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPV 101 LD+ +L I D + +RS+T +TE +I AA L I +G + +D+DAA K G+ V Sbjct: 32 LDEAELINQIADYQALIVRSQTQVTEAIIEAAPNLKVIARAGVGVDNIDVDAATKHGVIV 91 Query: 102 FNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGH 161 NAP NT S E + +L + R +P+A+ G W++ E K LG+IG G Sbjct: 92 INAPDGNTISATEHSMAMILSMARNIPQAHQSLKDGKWDRKTYRGTELYNKTLGVIGAGR 151 Query: 162 IGTQLGILAESLGMYVYFYD---IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTK 218 IG + A+S GM++ +D E+K N T+ + ++ SD V++H P P TK Sbjct: 152 IGLGVAKRAQSFGMHILAFDPYLSEDKAKELNVTRAT-VEEIAEQSDFVTVHTPLTPKTK 210 Query: 219 NMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFT 278 ++G KP +IN +RG ++D AL DAL + AAIDVF +EPAT Sbjct: 211 GIVGKAFFEKAKPNLQIINVARGGIIDEAALVDALNQNQIQSAAIDVFESEPATE----- 265 Query: 279 SPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVS 331 SPL + +++TPH+G ST EAQE + + VA +++ +NG+ +A+N P+++ Sbjct: 266 SPLVNHEKIIVTPHLGASTVEAQEKVAVSVANEIVDIFENGNVFNAINAPKMT 318 >UniRef50_B4D991 D-3-phosphoglycerate dehydrogenase n=3 Tax=Verrucomicrobia RepID=B4D991_9BACT Length = 530 Score = 185 bits (470), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 117/324 (36%), Positives = 172/324 (53%), Gaps = 8/324 (2%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K K L+ + + QK ++ L G ++ G DE L I + + + +RS T V Sbjct: 3 KPKVLVADPIAQKGIDELANGGSLDVTVKIGLKPDELLA-IIGEFNALVVRSETKANAKV 61 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I AA L IG +G + VD+DAA KRGI V N P NT S AE ++ R +P+ Sbjct: 62 IEAATNLKVIGRAGVGVDNVDVDAATKRGIIVMNTPGGNTISTAEHAFSLMVSTARNIPQ 121 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 A+A G W++ E K L I+G G IGT++ A + GM V YD Sbjct: 122 ADASVKSGKWDRKTFVGVELYNKTLAILGMGRIGTEIARRAIAFGMRVLAYDPYLSASRA 181 Query: 190 NATQVQHLSDL---LNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + QV+ + L + +D ++LH+P TK M+ A+ ++ K G ++N +RG ++D Sbjct: 182 RSLQVELVESLDLIIPQADFITLHMPLTAETKYMLNAERLAKTKKGVRIVNCARGGLIDE 241 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL +AL SK +A AA+DVF EP P SPL N++LTPH+G ST EAQE +G+ Sbjct: 242 AALVEALKSKQVAAAALDVFEAEPL----PAESPLRGLPNLILTPHLGASTAEAQEGVGI 297 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEV 330 EVA ++ +G +AVN P + Sbjct: 298 EVAEQIRAALLSGEIRNAVNMPSI 321 >UniRef50_Q5WGX7 D-3-phosphoglycerate dehydrogenase n=8 Tax=Bacillaceae RepID=Q5WGX7_BACSK Length = 533 Score = 184 bits (467), Expect = 5e-45, Method: Compositional matrix adjust. Identities = 103/274 (37%), Positives = 159/274 (58%), Gaps = 11/274 (4%) Query: 59 LRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIG 118 +RS T +TE++++ +L + +G + VD+ AA K G+ V NAP NT S AE Sbjct: 55 IRSATTVTEELLSRMPRLKIVARAGVGVDNVDIQAATKHGVVVINAPDGNTISTAEHTFA 114 Query: 119 ELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVY 178 + LLR +P+ANA G W++ A E RGK LGI+G+G IGTQL A++ M V Sbjct: 115 MMCALLRNIPQANASVKSGKWDRKAYQGTELRGKTLGIVGFGRIGTQLAKRAKAFEMGVL 174 Query: 179 FYD----IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSL 234 YD E LG A L +L+++D++++H P TK ++ + I+ KPG Sbjct: 175 VYDPFLTAERAEKLGIAQ--GELDHVLSVADIITVHTPLTKDTKGLLNMETIAKTKPGVF 232 Query: 235 LINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIG 294 LIN +RG ++D AL L + H+AGAA+DVF EPAT+ + P +V+ TPHI Sbjct: 233 LINCARGGIIDEQALKHYLNNGHVAGAALDVFTEEPATDKELIGHP-----SVVATPHIA 287 Query: 295 GSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFP 328 ST+EAQ N+ +V+ +++++ + L+++N P Sbjct: 288 ASTKEAQLNVAAQVSQEVLQFLNGEPALNSINLP 321 >UniRef50_O29445 D-3-phosphoglycerate dehydrogenase n=8 Tax=cellular organisms RepID=SERA_ARCFU Length = 527 Score = 183 bits (465), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 108/322 (33%), Positives = 176/322 (54%), Gaps = 8/322 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ E + ++A++ +R G +E G + E+L + I +RS+T + +VI Sbjct: 1 MKVLVAEPISEEAIDYMRKNGL-EVEVKTG-MSREELIREVPKYEAIVVRSQTKVDAEVI 58 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA+ L IG +G + +D++AA +RGI V NAP NT S AE I +L R +P+A Sbjct: 59 QAAKNLKIIGRAGVGVDNIDINAATQRGIVVVNAPGGNTISTAEHAIALMLAAARKIPQA 118 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IENKLPL 188 + G W + E RGK G+IG G +G ++ ++L M V YD + + Sbjct: 119 DRSVKEGKWERKKFMGIELRGKTAGVIGLGRVGFEVAKRCKALEMNVLAYDPFVSKERAE 178 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 ++ LL SDV+++HVP T ++G + MK G +++NA+RG +VD A Sbjct: 179 QIGVKLVDFDTLLASSDVITVHVPRTKETIGLIGKGQFEKMKDGVIVVNAARGGIVDEAA 238 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +A+ + +A AA+DV+ EP + + PL + DNV+ TPHI ST+EAQ N+G+ + Sbjct: 239 LYEAIKAGKVAAAALDVYEKEPPSPDN----PLLKLDNVVTTPHIAASTREAQLNVGMII 294 Query: 309 AGKLIKYSDNGSTLSAVNFPEV 330 A ++ + +AVN P + Sbjct: 295 AEDIVNMAKGLPVRNAVNLPSI 316 >UniRef50_B2V7I1 D-3-phosphoglycerate dehydrogenase n=8 Tax=Aquificales RepID=B2V7I1_SULSY Length = 529 Score = 182 bits (463), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 114/320 (35%), Positives = 173/320 (54%), Gaps = 7/320 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + K LE L ++++ + +L E I+D I RSRT +T++++ Sbjct: 3 KVLVTDDISPKGLEILSNDEEIDLDYQP-EIKFNELLEIIKDYDAIITRSRTPVTKELLE 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AEKL IG +G + VDL+ A++RGI V N P +NT AE+ + L +LR + A+ Sbjct: 62 RAEKLKVIGRAGVGVDNVDLEEASRRGILVVNTPGANTIGAAEITMAHLYAVLRKLHLAH 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 G W + E GK +GIIG G++G+Q+ I ++ G V YD G+ Sbjct: 122 DSVKAGEWKRSKFMGEELDGKVVGIIGLGNVGSQVAIRCKAAGAKVIAYDPYIPKEKGDR 181 Query: 192 TQVQHLSD---LLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 V+ + D L+ +SD+++LH P T+NM+G KE LMK G IN +RG +VD A Sbjct: 182 LGVEIIDDLHELIKISDIITLHCPLTEETRNMIGKKEFDLMKKGVYFINCARGGIVDEDA 241 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L DA+ +AG +DVF EP D L EF N+ L+PHIG +T E+Q+N+ +++ Sbjct: 242 LYDAIQEGKIAGLGLDVFSKEP---PDERIRRLFEFPNISLSPHIGANTYESQDNVAIKI 298 Query: 309 AGKLIKYSDNGSTLSAVNFP 328 A +I AVN P Sbjct: 299 AQYVIAALKGQFVEVAVNAP 318 >UniRef50_B8CX87 D-3-phosphoglycerate dehydrogenase n=1 Tax=Halothermothrix orenii H 168 RepID=B8CX87_HALOH Length = 527 Score = 181 bits (460), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 111/326 (34%), Positives = 178/326 (54%), Gaps = 14/326 (4%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + K +E L ++ F+ L E+ + I + + +RS T + ++ ++ Sbjct: 3 KVLVSDNISPKGIEILEQEA--DVTFNPD-LSREEFLDIIGEYDGLIVRSMTEVDKEALD 59 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A L IG G + +D++ A+KRGI VFN P NT S E IG +L L R +P+AN Sbjct: 60 KARNLKVIGRAGTGYDNIDIEEASKRGIIVFNTPTGNTISAVEHTIGMMLALSRNIPQAN 119 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 H G+W++ E +GK LGIIG G IG+++ + A++ GM V D LP A Sbjct: 120 QALHEGIWDRKKYMGVEVKGKTLGIIGLGRIGSRVAVRAQAFGMKVIAND--PYLPPEKA 177 Query: 192 TQVQ----HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 ++ ++L SD ++LH P T +++ KE ++MK +IN +RG VD Sbjct: 178 AKINVPLLGFKEVLKKSDYITLHTPLTDETYHILSHKEFAIMKDNVRIINCARGKNVDTQ 237 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEF-DNVLLTPHIGGSTQEAQENIGL 306 AL ALA +AGAAIDV EP P +PL ++ D V++T H+GG+T EA +N+ + Sbjct: 238 ALAKALAEHKVAGAAIDVHEVEPL----PEDNPLLKYQDRVIMTCHLGGTTTEAMDNVSI 293 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEVSL 332 A +++ +NG S +N P +++ Sbjct: 294 AAAEQVLDVLNNGLPESPLNIPSINI 319 >UniRef50_D1VVP3 Phosphoglycerate dehydrogenase n=1 Tax=Peptoniphilus lacrimalis 315-B RepID=D1VVP3_9FIRM Length = 315 Score = 181 bits (460), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 109/303 (35%), Positives = 171/303 (56%), Gaps = 11/303 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGAL-DDEQLKESIRDAHFIGLRSRTHLTEDV 69 +K L+++ + ++ + L+ G IEF K L ++L + I D + +R + +D+ Sbjct: 1 MKALIIDQMSEEIDKGLKERG---IEFKKVMLPKKDELIKLIPDVDVLIMRVDPFIDKDI 57 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 ++AA+ L I +GTN +DL+ KR IPV N+P N+ +VAELV + L L R + Sbjct: 58 LDAAKNLKLILVGSVGTNHIDLEECKKRNIPVMNSPGQNSNAVAELVFSKALDLYRNTVQ 117 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IENKLP 187 AN + G+WNK E R K +GI+GYG IG ++ +A M V YD + K Sbjct: 118 ANNEVKSGIWNKYRWIGRELRNKTMGILGYGSIGRRVAEIAHVFKMDVLAYDPYFDPKNN 177 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + ++ L + L SDV++LH+P TKNM+ +K++ M+ G++LINA+RG V+D Sbjct: 178 PYDYVKLVSLDEALKNSDVITLHLPLTKETKNMISSKQMEGMRDGTILINAARGGVIDED 237 Query: 248 ALCDALASKHLAGAAIDVFPTEPA-----TNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 AL + + + L GA +D E T P +S L E D V ++PHIGGST +AQ+ Sbjct: 238 ALYEYIKNGKLGGANLDTLADELGTGGLDTQDVPISSKLFELDRVYMSPHIGGSTIDAQD 297 Query: 303 NIG 305 +IG Sbjct: 298 DIG 300 >UniRef50_Q4L766 D-3-phosphoglycerate dehydrogenase n=3 Tax=Staphylococcus RepID=Q4L766_STAHJ Length = 532 Score = 180 bits (456), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 113/327 (34%), Positives = 176/327 (53%), Gaps = 12/327 (3%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K L+ + + L+SL N++ K LD++ L + I D + +RS+T +T+ V Sbjct: 2 KHNILVSDPISTDGLQSLLNHSDFNVDI-KTDLDEQSLLDIIGDYEGLIVRSQTQVTQQV 60 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I A L I +G + +D+DAA +GI V NAP NT S E + +L + R +P+ Sbjct: 61 IEKASNLKVIARAGVGVDNIDIDAATLQGILVINAPDGNTISATEHSVAMILAMARNIPQ 120 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD---IENKL 186 A+A WN+ A E K LG+IG G IG + +S GM V YD E+K Sbjct: 121 AHASLKNKEWNRKAFKGVELYQKTLGVIGAGRIGIGVAQRLQSFGMKVLAYDPYLTEDKA 180 Query: 187 -PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 LG ++ + ++ +D V++H P P T+ ++ A S KP +IN +RG +++ Sbjct: 181 QQLG--VKLATIDEIARQADFVTVHTPLTPKTRGIVNADFFSKAKPTLQIINVARGGIIN 238 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 L +AL + +A AA+DVF EP P SPL E D +++TPH+G ST EAQE + Sbjct: 239 EDDLLNALNNNQIARAALDVFEHEP-----PTDSPLIEHDKIIVTPHLGASTIEAQEKVA 293 Query: 306 LEVAGKLIKYSDNGSTLSAVNFPEVSL 332 + V+ ++I +NG+ AVN P++S Sbjct: 294 VSVSEEIIDILENGNVTHAVNAPKISF 320 >UniRef50_UPI0001C41AB7 phosphoglycerate dehydrogenase SerA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41AB7 Length = 524 Score = 180 bits (456), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 109/326 (33%), Positives = 181/326 (55%), Gaps = 15/326 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ + +++K +E+L+ ++ ++ E+L E+I + I +RSRT L +VI Sbjct: 1 MKALVADAINEKGIENLKEVCDVVVDT---SITPEELLETIGEYDAILIRSRTKLPAEVI 57 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A+ L I +G + VD++AA K+GI V NAP S + +VAE +G +L +R + A Sbjct: 58 EKADNLKIIARAGVGVDNVDVNAATKKGIMVVNAPESTSITVAEHTMGLILSTIRKIAIA 117 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + G W K A E R K LG+IG G IG+Q+ ++ M YD LP Sbjct: 118 DKSTKAGKWEKKAFMGMELRNKTLGVIGMGRIGSQVVNRCKAFEMDAIAYD--PYLPPEV 175 Query: 191 ATQV-----QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 A + + + D+L +D++++HVP P T++ + ++ +MK +L+ N +RG V+D Sbjct: 176 AKNMGVELYEDIEDVLTRADIITIHVPLTPETEHSISTEQFKMMKDTALIFNCARGGVID 235 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL +AL + + GA +DV+ EPATN+ F E DN++ TPHI ST+EAQ + Sbjct: 236 EDALYEALVNGEILGAGLDVYEKEPATNNKLF-----ELDNIVCTPHIAASTKEAQRDAA 290 Query: 306 LEVAGKLIKYSDNGSTLSAVNFPEVS 331 + VA ++I G + +N P ++ Sbjct: 291 IIVANEVITLFKGGMPKNIINMPRMN 316 >UniRef50_B1KZ88 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=29 Tax=Clostridiaceae RepID=B1KZ88_CLOBM Length = 314 Score = 179 bits (454), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 110/314 (35%), Positives = 171/314 (54%), Gaps = 16/314 (5%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 IK L+ +G+ + AL L G+ ++ H + E+LK+ I+D I +RS T + +++I Sbjct: 2 IKILVSDGMEKNALNKLNEQGFVVLDKH---FEKEELKDKIKDFDAIIIRSATKVDKEII 58 Query: 71 NAAEK-----LVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 +A K +V G +G + VDL+ A ++G+ VFN P +++ SVAEL +G +L + R Sbjct: 59 DAGIKGNLKLVVRAG---VGLDNVDLEYAKEKGVKVFNTPKASSVSVAELTLGHMLCISR 115 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 + AN +G W K E GK LG+IG+G I ++ A +LGM V +YDI K Sbjct: 116 FINTANVTMLQGKWEKKKYKGTEIYGKTLGLIGFGRIAREVAKRANALGMNVIYYDIAGK 175 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 + L LLN SD +S+H+P N ++ +E + MK G ++N +RG V++ Sbjct: 176 CEEYEEFKCCTLDYLLNNSDFISVHIPFNKDRGALLKEEEFNKMKDGVYIVNCARGGVIE 235 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL AL + + AA+DVF EP + L + V +TPHIG ST+EAQ IG Sbjct: 236 EEALLKALNNGKVTAAALDVFENEPEPKKE-----LINHERVSITPHIGASTKEAQMRIG 290 Query: 306 LEVAGKLIKYSDNG 319 E+ L + + G Sbjct: 291 EEIVDILDNFFNVG 304 >UniRef50_A1HMI9 Phosphoglycerate dehydrogenase n=1 Tax=Thermosinus carboxydivorans Nor1 RepID=A1HMI9_9FIRM Length = 326 Score = 179 bits (453), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 109/311 (35%), Positives = 173/311 (55%), Gaps = 21/311 (6%) Query: 24 LESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFC 83 +ES++ +G T ++ L+D++ ++++ A + L + +T+++I A KL I Sbjct: 18 IESIKPSGVTVTYWY--TLNDKEKEQALNSADYF-LVALYKITQELIQKAPKLKMIQKTG 74 Query: 84 IGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVW--NK 141 +G + +DL AA GIPV N P N SVAEL +G ++ L R + + + +G W + Sbjct: 75 VGVDNIDLAAAKTLGIPVANTPGGNATSVAELTLGMIINLYRKINILDRETKKGNWMSWE 134 Query: 142 LAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA---TQVQHLS 198 S+E +GK GIIG+G+IG ++ L+++ G V +YD+ P L+ Sbjct: 135 FRPSSYEVKGKTHGIIGFGNIGREVARLSQAFGTNVIYYDLRRLEPAEEKRLNVTYHELN 194 Query: 199 DLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHL 258 +LL SD++S+H+P P TKN++ +E++L+KP +LLIN +RG +VD AL AL L Sbjct: 195 ELLQKSDIISIHLPLTPDTKNLISERELALLKPTALLINVARGNIVDEVALYRALKENKL 254 Query: 259 AGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQE--------AQENIGLEVAG 310 GA IDV+ EP + +PL +NVL TPHIG T++ A ENI G Sbjct: 255 LGAGIDVWSKEPVED-----NPLLTLNNVLATPHIGAGTRDTLQTVLGLAFENIIATTRG 309 Query: 311 KLIKYSDNGST 321 K ++ NG T Sbjct: 310 KNPRFVVNGVT 320 >UniRef50_B3T9W6 Putative D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein n=1 Tax=uncultured marine microorganism HF4000_APKG7H23 RepID=B3T9W6_9ZZZZ Length = 491 Score = 178 bits (452), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 102/276 (36%), Positives = 156/276 (56%), Gaps = 11/276 (3%) Query: 59 LRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIG 118 +RS T +T +I A L IG +G + VDLDAA ++GIPV NAP NT + AE + Sbjct: 13 VRSETQVTAGLIEAGGHLQVIGRAGVGVDNVDLDAATRQGIPVVNAPTGNTVAAAEHTLA 72 Query: 119 ELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVY 178 +L ++R +P+A+A G W + A E RGK LGIIG G +G+++ +L M + Sbjct: 73 LMLAMVRHIPQADASVRMGEWRRSAFMGVEVRGKILGIIGLGKVGSEVARRTRALQMRIL 132 Query: 179 FYD----IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSL 234 +D E+ LG ++ L L+ +D +++H P +T+ ++G + +K G Sbjct: 133 AHDPFVPQESARSLG--VEMVSLDQLMAEADFITIHTPLTATTQQLLGPAQFQQLKHGVR 190 Query: 235 LINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIG 294 +INA+RG +V+ L +AL S +AGAA+DVF EP P SPL + V+LTPH+G Sbjct: 191 IINAARGGLVNEQLLLEALESGRVAGAALDVFVEEP-----PKQSPLLQHPRVVLTPHLG 245 Query: 295 GSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEV 330 ST+EAQ + LE+A +++ S VN P + Sbjct: 246 ASTEEAQTEVALEIADQVLAVLAGSSAQYTVNVPYI 281 >UniRef50_Q67TJ9 Phosphoglycerate dehydrogenase n=1 Tax=Symbiobacterium thermophilum RepID=Q67TJ9_SYMTH Length = 540 Score = 178 bits (452), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 112/326 (34%), Positives = 176/326 (53%), Gaps = 17/326 (5%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ E + + + LR ++ + E+L E I + + RS T +T +V+ Sbjct: 1 MKILVTEAISETGISLLRDEHEVDVR----KVTSEELLEIIPEYDALITRSETKVTAEVL 56 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +L +G +G + +D+ AA +RG+ V N P +NT S AE G L+ + R +P+A Sbjct: 57 ARGTRLKVVGRAGVGVDNIDVAAATERGVVVVNVPGANTYSTAEHAFGLLIAVARNIPQA 116 Query: 131 N-AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 + A A G W++++ E GK LGIIG G IG+++ + A + GM V YD +P Sbjct: 117 HHALAREGRWDRMSFVGTELHGKTLGIIGLGRIGSEVAVRARAFGMRVLAYD--PYVPHS 174 Query: 190 NA-----TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 A T V L LL D +++H + P + ++GA E++LMKP + ++N +RG +V Sbjct: 175 RAEHLGVTLVPSLRGLLPEVDFLTIHAAKTPESARLIGAAELALMKPTARIVNCARGGMV 234 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL AL LAGAA+DVF EP T+ SPL NV++TPH+ ST EAQ+ Sbjct: 235 DEEALYRALKEGRLAGAALDVFAAEPCTD-----SPLFGLPNVVVTPHLSASTAEAQDAN 289 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEV 330 G +A +++ AVN P++ Sbjct: 290 GRYIAQYVLRALRGELVPEAVNLPQI 315 >UniRef50_P73821 D-3-phosphoglycerate dehydrogenase n=40 Tax=Cyanobacteria RepID=SERA_SYNY3 Length = 554 Score = 178 bits (452), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 105/319 (32%), Positives = 174/319 (54%), Gaps = 10/319 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + Q ++ L+ ++ K L + ++ + + + I LRS T +TE +I Sbjct: 31 KVLVSDSIDQVGIDILKQVAQVDV---KTGLSEAEIIDIVPEYDAIMLRSATKVTEKIIQ 87 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A +L IG +G + +D+ AA ++GI V N+P NT + AE + ++ L R +P+AN Sbjct: 88 AGSQLKIIGRAGVGVDNIDVPAATRQGIVVVNSPEGNTIAAAEHALAMMMALARHIPDAN 147 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IENKLPLG 189 W + E K LG++G G IG+ + +A+++GM + YD I + Sbjct: 148 KSVKESKWERKQFIGTEVYKKTLGVVGLGKIGSHVAGVAKAMGMKLLAYDPFISQERADQ 207 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 + L L + +D ++LH+P+ P T N++ A+ ++ MKP + +IN SRG ++D AL Sbjct: 208 IGCTLVDLDLLFSEADFITLHIPKTPETANLINAETLAKMKPTARIINCSRGGIIDEEAL 267 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 A+ + + GAA+DVF EP S L EF NV+LTPH+G ST+EAQ N+ ++VA Sbjct: 268 VTAIETAQIGGAALDVFAQEPLGESR-----LREFSNVILTPHLGASTEEAQVNVAVDVA 322 Query: 310 GKLIKYSDNGSTLSAVNFP 328 ++ SAVN P Sbjct: 323 EQIRDVLLGLPARSAVNIP 341 >UniRef50_B1HVJ4 Phosphoglycerate dehydrogenase n=5 Tax=Bacillales RepID=B1HVJ4_LYSSC Length = 535 Score = 177 bits (450), Expect = 5e-43, Method: Compositional matrix adjust. Identities = 101/290 (34%), Positives = 162/290 (55%), Gaps = 11/290 (3%) Query: 45 EQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNA 104 E+L I D + +RS+T +T +VI AA+ L IG +G + +DL AA + GI V NA Sbjct: 43 EELMTKIADVDVLLVRSQTTVTREVIEAAKSLKLIGRAGVGVDNIDLTAATEHGIIVVNA 102 Query: 105 PFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGT 164 P NT S AE I + L R +P+A G W++ + E + K LG++G+G IG Sbjct: 103 PDGNTNSAAEHTIAMMTSLARHIPQAFNTLKNGKWDRKSYVGVELKNKTLGVVGFGRIGV 162 Query: 165 QLGILAESLGMYVYFYD----IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNM 220 ++ A+ M V YD E LG + ++ +D +++H P P T+N+ Sbjct: 163 EVAYRAKGQRMNVMAYDPFLTDERAKELG--VTKASVEEICEAADFITVHTPLLPETRNL 220 Query: 221 MGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSP 280 + ++ ++MK G +IN +RG +++ L DA+ + +AGAA+DVF +EPAT+ T P Sbjct: 221 INKEKFAMMKDGVRIINCARGGIINEDDLYDAIVAGKVAGAALDVFVSEPATDHKLLTLP 280 Query: 281 LCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEV 330 V+ TPH+G ST EAQE++ ++V+ +IK+ G+ + VN P + Sbjct: 281 -----QVIATPHLGASTIEAQESVAVDVSNDIIKFYKTGTVTNPVNMPSI 325 >UniRef50_O43175 D-3-phosphoglycerate dehydrogenase n=53 Tax=Bilateria RepID=SERA_HUMAN Length = 533 Score = 177 bits (448), Expect = 8e-43, Method: Compositional matrix adjust. Identities = 111/317 (35%), Positives = 162/317 (51%), Gaps = 9/317 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + + L+ G +E K L E+L ++D + +RS T +T DVIN Sbjct: 8 KVLISDSLDPCCRKILQDGGLQVVE--KQNLSKEELIAELQDCEGLIVRSATKVTADVIN 65 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AAEKL +G G + VDL+AA ++GI V N P N+ S AEL G ++ L R +P+A Sbjct: 66 AAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQAT 125 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IENKLPLG 189 A G W + E GK LGI+G G IG ++ +S GM YD I ++ Sbjct: 126 ASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSAS 185 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 Q L ++ + D +++H P PST ++ + K G ++N +RG +VD AL Sbjct: 186 FGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGAL 245 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 AL S AGAA+DVF EP P L + +NV+ PH+G ST+EAQ G E+A Sbjct: 246 LRALQSGQCAGAALDVFTEEP-----PRDRALVDHENVISCPHLGASTKEAQSRCGEEIA 300 Query: 310 GKLIKYSDNGSTLSAVN 326 + + S VN Sbjct: 301 VQFVDMVKGKSLTGVVN 317 >UniRef50_A7HDB1 D-3-phosphoglycerate dehydrogenase n=3 Tax=Proteobacteria RepID=A7HDB1_ANADF Length = 528 Score = 176 bits (447), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 119/321 (37%), Positives = 174/321 (54%), Gaps = 12/321 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ + + +A+ L+ AG ++ G L +QL+ + D + +RS T +T +++ Sbjct: 4 RVLVSDDLSPEAVRILQEAGL-EVDVKVG-LKPDQLERIVGDYDGLAVRSATKVTAQLLD 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A +L IG +G + VDL AA +RG+ V N P ++ +VAEL + +L L R V A Sbjct: 62 KAARLKVIGRAGVGVDNVDLAAATRRGVVVMNTPGGSSITVAELALSMILALSRHVAAAT 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD----IENKLP 187 G W K E G+ LG++G G+IG+ L A +LGM V +D E Sbjct: 122 GSVKAGKWEKKRFQGHELAGRTLGVVGIGNIGSVLVARAVALGMRVVAFDPFISAEAAAK 181 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 LG + L L +DVVS+HVP T++++ A + MK G+LL+N +RG +VD Sbjct: 182 LG--ASLVDLDTLWREADVVSIHVPLTDKTRHLVDATALGKMKKGALLVNCARGGIVDER 239 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL DAL S L GA +DVF EP P PL +NV+LTPHIG ST+EAQ + + Sbjct: 240 ALADALRSGQLGGAGLDVFEQEP----PPADHPLYGLENVILTPHIGASTEEAQSAVAVA 295 Query: 308 VAGKLIKYSDNGSTLSAVNFP 328 VA +L Y G +AVN P Sbjct: 296 VAEQLADYLVRGVVRNAVNAP 316 >UniRef50_P35136 D-3-phosphoglycerate dehydrogenase n=12 Tax=Bacillales RepID=SERA_BACSU Length = 525 Score = 176 bits (447), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 103/320 (32%), Positives = 172/320 (53%), Gaps = 9/320 (2%) Query: 59 LRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIG 118 +RS T +TED+ N L +G +G + +D+D A K G+ V NAP NT S AE Sbjct: 46 VRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEHTFA 105 Query: 119 ELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVY 178 + L+R +P+AN WN+ A E GK LGI+G G IG+++ A + GM V+ Sbjct: 106 MISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAFGMTVH 165 Query: 179 FYD--IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLI 236 +D + + + ++L +D++++H P TK ++ + I+ K G LI Sbjct: 166 VFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKTKKGVRLI 225 Query: 237 NASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGS 296 N +RG ++D AL +AL + H+AGAA+DVF EP ++ PL V+ TPH+G S Sbjct: 226 NCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPL-----VIATPHLGAS 280 Query: 297 TQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNK 356 T+EAQ N+ +V+ ++++++ +SA+N P ++ + H + G L +++ Sbjct: 281 TKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGSL--VSQ 338 Query: 357 IFAEQGVNIAAQYLQTSAQM 376 E ++A QY T A++ Sbjct: 339 CMKEPVQDVAIQYEGTIAKL 358 >UniRef50_Q3AQU0 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chlorobiaceae RepID=Q3AQU0_CHLCH Length = 538 Score = 176 bits (447), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 114/341 (33%), Positives = 183/341 (53%), Gaps = 9/341 (2%) Query: 8 KDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 ++ +K L+ + VH + L G+ E K +L ++L I D + + +RS T L Sbjct: 10 ENVMKVLITDSVHPQCGRLLLQHGFEVTE--KPSLSPKELHAIIADYNILIVRSATSLPA 67 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 +V+ A +L IG G + +DL+AA ++GI V + P N S AE LL R + Sbjct: 68 EVLAKATQLELIGRAGTGVDNIDLEAATRQGIVVMSTPGGNAVSAAEHTCAMLLAAARHI 127 Query: 128 PEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IENK 185 P+A A +G WNK E GK L +IG G +G ++ + ++ GM YD I ++ Sbjct: 128 PQAMADLKQGNWNKHLYAGIELEGKTLSLIGLGRVGREVAMRMQAFGMRTIAYDPAIADE 187 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 ++ L + L +DV+++H + ST N++G + +SL KPG +++N +RG +++ Sbjct: 188 DAALLDIELLPLHENLLRADVITIHSALDESTYNLLGKETLSLTKPGVIIVNCARGGIIN 247 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL +ALAS H+A AA+DVF EP T PL +F V+ TPHI ST E QE + Sbjct: 248 EVALAEALASGHVAAAALDVFTKEPIAA----THPLLQFPQVIATPHISASTAEGQEKVA 303 Query: 306 LEVAGKLIKYSDNGSTLSAVNFPEVSLP-LHGGRRLMHIHE 345 +++A ++I + +G A+N V L L G +H+ E Sbjct: 304 IQMAEQIIAWKRDGILEGAINGTIVELAQLPGAHAYLHLAE 344 >UniRef50_A0LMX1 D-3-phosphoglycerate dehydrogenase n=1 Tax=Syntrophobacter fumaroxidans MPOB RepID=A0LMX1_SYNFM Length = 525 Score = 176 bits (446), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 111/325 (34%), Positives = 175/325 (53%), Gaps = 14/325 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEF--HKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 +K L+ +G+H+ L LRAA +++ GA E++K + D + +RSRT +T + Sbjct: 1 MKVLICDGMHEVGLSILRAAEGIDVDVPDQPGA---EEIKAMLPDYDAVIVRSRTRITAE 57 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 +I A +L IG G + +D+ AA+ RG V N P +N + AE I +L L R +P Sbjct: 58 LIENAPRLKVIGRAGTGVDNIDVKAASARGALVMNTPGANATAAAEHTIAMMLALARHIP 117 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL 188 +A G W+K E + LGIIG G IG+ + A S+ M V +D +P Sbjct: 118 QATQSMREGRWDKKRFMGTELFHQTLGIIGLGKIGSIVADRALSMKMDVLGHD-PYIIPE 176 Query: 189 GNA---TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 A + L +LL SD ++LH P T ++ + ++ KPG ++N +RG ++D Sbjct: 177 AAAILGVEWVPLDELLARSDFLTLHTPSTSETVRILNRETLARTKPGVRILNCARGGLID 236 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL + L + H+ GAA+DVF EP P SPL + +NV+ TPH+G S+ +AQ N+ Sbjct: 237 EQALYEFLLNGHVGGAALDVFEQEP-----PVDSPLLKLENVIFTPHLGASSYQAQANVA 291 Query: 306 LEVAGKLIKYSDNGSTLSAVNFPEV 330 +A +++ Y G +AVNFP + Sbjct: 292 RAIATQIVDYLLYGIIRNAVNFPSI 316 >UniRef50_B6KF90 D-3-phosphoglycerate dehydrogenase, putative n=3 Tax=Toxoplasma gondii RepID=B6KF90_TOXGO Length = 604 Score = 175 bits (444), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 111/321 (34%), Positives = 177/321 (55%), Gaps = 6/321 (1%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 + + L+ + + Q ++ L + + +++ K L +E+L + + + +RS T +TE + Sbjct: 15 RFRVLVCDPIDQAGMDIL--SSFADVDT-KLKLSEEELCRVVGNYDGLMVRSGTTVTEKI 71 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I +KL IG +G + V +DAA +GI V N+P NT + AEL +G ++ L R +P+ Sbjct: 72 IKHGQKLKIIGRAGVGVDNVCVDAATAQGIFVVNSPNGNTMAAAELTLGLMMALARKIPQ 131 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IENKLP 187 A+A RG W + + K +GIIG G +GT + + +LGM V YD I + Sbjct: 132 ADASVSRGEWTRSKFMGRQLNQKTIGIIGLGQVGTHVARVCTALGMEVLAYDPFINEEKA 191 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + L LL SD ++LHVP T++++ A ++ L+K + +INASRG V+D Sbjct: 192 KAVGCRNVALETLLASSDFITLHVPLLDKTRHLINADKLKLIKKDACIINASRGGVIDEK 251 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSD-PFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 A+ +AL + LAGAA+DVF E + D P N++LTPHIG ST EAQ N+ + Sbjct: 252 AVAEALMANELAGAALDVFEEEKEFSKDNPLIQAKANGRNIILTPHIGASTLEAQHNVAV 311 Query: 307 EVAGKLIKYSDNGSTLSAVNF 327 +VA + + G SAVN Sbjct: 312 DVALQFREALLGGLPQSAVNL 332 >UniRef50_A8ZXY9 D-3-phosphoglycerate dehydrogenase n=6 Tax=Deltaproteobacteria RepID=A8ZXY9_DESOH Length = 532 Score = 175 bits (444), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 112/322 (34%), Positives = 166/322 (51%), Gaps = 25/322 (7%) Query: 25 ESLRAAGYTNIEFHKG-------ALDDEQLKESIRDAHFIGLRSRTHLTEDVINA-AEKL 76 +++ A+G + +E G L E+LK I + +RS T +T D++ A A KL Sbjct: 9 DTIDASGVSRLENESGFAVDVKTGLPPEELKSIIGQYDALIIRSATKVTADILEAGAPKL 68 Query: 77 VAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHR 136 A+ IG + VD+ AA K G+ V N P N + AE I ++ L R +P+ Sbjct: 69 KAVARAGIGLDNVDIPAATKHGVAVMNTPEGNVVTTAEHTIAMMMALTRNIPQGTLSLRS 128 Query: 137 GVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD-------IENKLPLG 189 G W K E K LG+IG+G IG+ + A L M V +D IEN+ Sbjct: 129 GQWEKKKLQGREVFNKTLGVIGFGKIGSIVADRARQLKMNVIVFDPNIARTTIENE---- 184 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 + L DL +D +++HVP+ T ++ MK G +++N +RG +VD L Sbjct: 185 -GFEYVSLDDLFARADYITVHVPKLKQTVGLLNKAAFEKMKTGVMVLNCARGGIVDEADL 243 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 DAL S +A AA+DVF TEP P PL + DNV+ TPH+G ST+EAQ N+ A Sbjct: 244 YDALMSGRVAAAALDVFVTEP-----PGEHPLLKLDNVIATPHLGASTKEAQVNVAEAAA 298 Query: 310 GKLIKYSDNGSTLSAVNFPEVS 331 ++I++ N + ++AVN P VS Sbjct: 299 HQIIEFLKNNTVINAVNLPAVS 320 >UniRef50_A7BQE7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Beggiatoa sp. PS RepID=A7BQE7_9GAMM Length = 302 Score = 175 bits (443), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 115/310 (37%), Positives = 168/310 (54%), Gaps = 15/310 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K LLVE ++ +A+ +LR+ +E + E+L E I D + L+SR L ++ I Sbjct: 1 MKILLVEPIYCEAIIALRSKFELFVEILP---NKERLLEVIEDKDVVILKSRIELDKEAI 57 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA+ L + IG + + LD KRGI FN P + R VAELV+G L L R + Sbjct: 58 FAAKHLKLVVMAGIGLDHICLDELKKRGIAWFNIPDLSARGVAELVLGLTLSLARKICLG 117 Query: 131 NAKAHRG---VWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGM--YVYFYDIENK 185 ++ +W + F + + GI+GYG IG ++ +A+ GM VY + ++K Sbjct: 118 DSLLRNNEFKLWKRPELMGFNLQDRLFGIVGYGKIGKEMASVAKCFGMKVQVYVRNSDHK 177 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 N T V +LL SDV+S+HVP TK M E LM+ +LLIN SRG VV+ Sbjct: 178 TFEQNITPVT-FQNLLKTSDVISIHVPLTDETKGMFSKPEFELMQETALLINTSRGGVVN 236 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 L AL SK + GAA+DVF + +S L E DN+++TPHIG TQE QE IG Sbjct: 237 EKDLYHALKSKIIGGAALDVFEQKKPDDS------LFELDNIVVTPHIGAMTQETQEQIG 290 Query: 306 LEVAGKLIKY 315 L++ K+ ++ Sbjct: 291 LQIVKKIFEF 300 >UniRef50_B8HPZ0 D-3-phosphoglycerate dehydrogenase n=26 Tax=cellular organisms RepID=B8HPZ0_CYAP4 Length = 652 Score = 175 bits (443), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 108/320 (33%), Positives = 177/320 (55%), Gaps = 11/320 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + Q ++ L ++ + L E+L + I D + +RS T +T+ VI Sbjct: 129 KVLVSDPIDQVGIDLLAQVAQVDV---RTDLSPEELIQIIPDYDALMIRSGTKVTQAVIE 185 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AA +L IG +G + VD+ AA ++GI V N+P NT + AE + +L L R +P A+ Sbjct: 186 AANQLKIIGRAGVGVDNVDVPAATRKGIVVVNSPEGNTIAAAEHTLAMMLSLSRHIPAAS 245 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IENKLPLG 189 G W++ + E K LG+IG G IG+ + +A ++GM + YD + N+ Sbjct: 246 QSVKSGKWDRKSFTGVEVYKKTLGVIGLGKIGSHVATVARAMGMNLLAYDPYLSNERAEQ 305 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 ++ +L L +D ++LH+P+ P T++++ A+ ++ MKP + +IN +RG ++D AL Sbjct: 306 IGCRLVNLDLLFAEADYITLHLPKTPETQHLIKAETLARMKPTARIINCARGGIIDEAAL 365 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEF-DNVLLTPHIGGSTQEAQENIGLEV 308 +AL +AGAA+DVF EP SPL V+LTPH+G ST+EAQ N+ ++V Sbjct: 366 VEALKEGKIAGAALDVFENEPLGE-----SPLLSLGKEVVLTPHLGASTEEAQTNVAIDV 420 Query: 309 AGKLIKYSDNGSTLSAVNFP 328 A ++ SAVN P Sbjct: 421 AEQIRDLFLGKPVRSAVNIP 440 >UniRef50_A5GES6 D-3-phosphoglycerate dehydrogenase n=12 Tax=Desulfuromonadales RepID=A5GES6_GEOUR Length = 541 Score = 174 bits (442), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 109/334 (32%), Positives = 179/334 (53%), Gaps = 11/334 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K ++ + V Q+ LE L+ ++ G L E+L I D I RS T + +D++ Sbjct: 1 MKVIVTDEVAQEGLELLKQDPRVELDIRLG-LKKEELLAIIGDYEVIITRSGTTVDKDLL 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +A +KL + +G + VD+D A+ +G+ V NAPF NT S AE + LL R + +A Sbjct: 60 DAGKKLKMVARAGVGIDNVDIDYASSKGVIVVNAPFGNTNSAAEHAMALLLSFCRNITKA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 NA G W + E +GK G+IG G +G ++ ++ V D + + Sbjct: 120 NASLKSGEWKRAPFTGVELKGKTAGVIGLGKVGGRVATRLKAFECDVLGCDPYIAVKRAH 179 Query: 191 ATQVQHLS--DLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 V+ +S ++ D+++ H P N T+NM+G KEI++MK G +LINA+RG +++ A Sbjct: 180 DLGVKLVSHEEIYKNCDIITFHTPLNEETRNMVGEKEIAMMKDGVILINAARGGIINEQA 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEF---DNVLLTPHIGGSTQEAQENIG 305 L +AL + GAA+DV+ EP P + L E D +++TPH+G +T EAQ N+ Sbjct: 240 LLNALKGGKVFGAAMDVWSEEP-----PKSETLKELISQDKLVVTPHLGANTFEAQINVA 294 Query: 306 LEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRR 339 ++V+ +++ Y D +AVN P + L R Sbjct: 295 VDVSKEILNYLDEQPLENAVNIPRFDMALMDQMR 328 >UniRef50_C8WI96 D-3-phosphoglycerate dehydrogenase n=1 Tax=Eggerthella lenta DSM 2243 RepID=C8WI96_EGGLE Length = 526 Score = 174 bits (441), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 113/302 (37%), Positives = 163/302 (53%), Gaps = 12/302 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ E + + L LR G ++ K + E+L E++ + +RS T +T +V+ Sbjct: 4 KVLVTERLAEAGLAVLRDKG-CEVDV-KLKMTPEELIETVPGYDALIVRSATKVTAEVVE 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AA++L IG +G + VD++AA + GI V NAP SN S AE IG +L R VP+AN Sbjct: 62 AADRLRIIGRAGVGVDNVDVEAATEHGIIVCNAPTSNIVSAAEHAIGLMLACARKVPQAN 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD----IENKLP 187 A H GVW + E K L I G G IG + A + GM + YD E Sbjct: 122 ASMHEGVWERGKYTGVELYEKTLAIFGLGRIGGLVAERARAFGMKLIGYDPYCSPERAEQ 181 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 LG T + L+ ++D +++H+P+ T M G + + MK G +L+NA+RG + D Sbjct: 182 LG-VTLYDDVDALVPLADFITVHLPKTKETIGMFGPDQYARMKDGVILVNAARGGIFDEK 240 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 +L D LA+ + IDV +EP T+ SPL EFDN +LTPHI STQEAQ G++ Sbjct: 241 SLADFLAAGKIGAVGIDVHESEPCTD-----SPLREFDNAILTPHIAASTQEAQLRAGVQ 295 Query: 308 VA 309 A Sbjct: 296 TA 297 >UniRef50_C0QYX0 D-3-phosphoglycerate dehydrogenase n=2 Tax=Brachyspira RepID=C0QYX0_BRAHW Length = 534 Score = 173 bits (439), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 114/349 (32%), Positives = 186/349 (53%), Gaps = 18/349 (5%) Query: 42 LDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPV 101 + +++L + I + + +RS+T +T +I A + L IG +G + +D++AA ++GI V Sbjct: 29 MSEDELVKVIGEYDALMVRSQTKVTRKIIEAGKNLKIIGRAGVGVDNIDVEAATEKGIIV 88 Query: 102 FNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGH 161 N+P NT + +E I +L + R + A WN+ E GK LG++G+G Sbjct: 89 VNSPDGNTIAASEHTIALMLAVSRNIVPAAVSTKEAKWNRDKFTGNELLGKTLGVMGFGR 148 Query: 162 IGTQLGILAESLGMYVYFYD---IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTK 218 IG ++ +A ++GM V YD E + A L + L D +SLH+P+ P T Sbjct: 149 IGRKVVHIALAIGMKVIVYDPFATEEIVQKAGAVYETSLDEFLPKLDYLSLHIPKTPETN 208 Query: 219 NMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFT 278 N++ + MK +++IN SRG +V+ L +AL + +A AA+DVF EP T Sbjct: 209 NIINKDNLCKMKNTAIIINCSRGGLVNEEDLKNALENGTIAAAAVDVFVNEPKIE----T 264 Query: 279 SPLCEF--DNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVS-LPLH 335 PL E+ DN++LTPH+G ST+EAQ N+ L+VA ++ + G T SAVN P ++ L Sbjct: 265 CPLVEYKKDNLILTPHLGASTKEAQINVALDVAKQIKQVLSGGYTESAVNIPSLNPEKLE 324 Query: 336 GGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIE 384 + M I EN ++ Q N + L+ +AQ + +DI+ Sbjct: 325 PVKDYMKISENAGEMIM--------QTANGKIKSLEITAQGDLINLDIQ 365 >UniRef50_D1JIG3 D-3-phosphoglycerate dehydrogenase n=1 Tax=uncultured archaeon RepID=D1JIG3_9ARCH Length = 542 Score = 173 bits (439), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 108/332 (32%), Positives = 177/332 (53%), Gaps = 21/332 (6%) Query: 4 VSLEKDKI-KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSR 62 V++EK K L+ + + ++ ++ LR G ++E L E L I + + +RS Sbjct: 3 VNMEKGTTSKVLVTDNISEEGIKKLREFGDVDVELD---LSKEDLAACIANYDALVIRSG 59 Query: 63 THLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLL 122 T +T+++I+A ++L IG +G + +D++ A ++GI V N+P +N+ S AE LL Sbjct: 60 TTVTKEIIDAGKRLKVIGRAGVGVDNIDVERATEKGILVVNSPEANSISAAEHTFAMLLS 119 Query: 123 LLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI 182 + R +P AN G W + E GK LG IG G +G+++ A+ GM V +D Sbjct: 120 ISRKIPAANVSLKSGKWERKKHMGVEVNGKVLGTIGLGRVGSEVAKRAKGFGMRVVAHD- 178 Query: 183 ENKLPLGNATQVQHL-------SDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLL 235 P +A + + L ++L +D ++LH P T +M+G E LMK G + Sbjct: 179 ----PFISAAKAKELGITLLGFKEVLATADFITLHTPLTKDTHHMIGKGEFELMKDGVRV 234 Query: 236 INASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGG 295 IN +RG ++D AL +A+ + +AGAA+DVF EP N D L E + V++TPH+G Sbjct: 235 INCARGGILDEDALKEAIKAGKVAGAALDVFEQEPPNNDD-----LLELEEVIVTPHLGA 289 Query: 296 STQEAQENIGLEVAGKLIKYSDNGSTLSAVNF 327 ST EAQ + +A ++I N +A+N Sbjct: 290 STTEAQRAAAVVIADEVIGALSNKPVKNALNM 321 >UniRef50_Q18DJ4 Phosphoglycerate dehydrogenase n=13 Tax=Halobacteriaceae RepID=Q18DJ4_HALWD Length = 534 Score = 173 bits (438), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 126/396 (31%), Positives = 190/396 (47%), Gaps = 30/396 (7%) Query: 11 IKFLLVEGVHQKALESLRAAGY-TNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 ++ L+ + + LE LRAAG+ + G DE L +I D + + +RS T + E V Sbjct: 3 MQVLVTDPIDDAGLERLRAAGHGVETAYDIG---DEALLNTITDVNALVVRSGTDVNEAV 59 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 AA L+ +G IG + +D+DAA + G+ V NAP N R+ AE + R +P+ Sbjct: 60 FEAASDLIIVGRAGIGVDNIDIDAATEHGVIVANAPEGNVRAAAEHTVAMTFAGARSIPQ 119 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IENKLP 187 A+A+ G W K E GK LG++G G +G ++ ESLGM + YD I Sbjct: 120 AHARLRTGEWAKSEYLGTEVNGKTLGVVGLGRVGQEVAKRLESLGMDLVAYDPYISEDRA 179 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 ++ L ++ +++H P T M+ E+ LM G LIN +RG VVD Sbjct: 180 ERLGAELVEFDTCLERAEFLTVHTPLTSETAGMISTTELELMD-GGYLINCARGGVVDED 238 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL A+ L GAA+DVF EP S L DN+++TPH+G ST+ AQEN+ Sbjct: 239 ALAAAVEDGVLDGAAVDVFADEPVAPD----SALLSVDNIVVTPHLGASTEAAQENVATS 294 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAA 367 +A ++ ++A+N P V + P + ++ AE IAA Sbjct: 295 IADQIDAAFAGAPVMNALNAPSVDESVF------------PRIRPYID--LAETAGKIAA 340 Query: 368 QYLQTSAQMGYVVIDIE---ADEDVAEKALQAMKAI 400 Q L ++ V + E ADEDV A+K + Sbjct: 341 QLLD--GRISSVSVSYEGDIADEDVELATASALKGV 374 >UniRef50_UPI0001973600 D-3-phosphoglycerate dehydrogenase n=1 Tax=Clostridium sp. M62/1 RepID=UPI0001973600 Length = 314 Score = 172 bits (437), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 100/280 (35%), Positives = 156/280 (55%), Gaps = 17/280 (6%) Query: 45 EQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNA 104 EQ+ I D + +R + +D++ AA+ L IG +G N +D++ A ++GI +FNA Sbjct: 34 EQVLAEIGDVDVLIMRVDPKIDKDILGAAKNLKIIGVCSVGLNHIDMEYAKEKGIQIFNA 93 Query: 105 PFSNTRSVAELVIGELLLLLRGVPEANAKAH-RGVWNKLAAGSFEARGKKLGIIGYGHIG 163 P N +VAEL I ++L + RG AN + W+K E RGK LG++G+G IG Sbjct: 94 PGLNANAVAELTISKMLDISRGTMTANYDVKVKHEWDKYKFVGRELRGKTLGVMGFGRIG 153 Query: 164 TQLGILAESLGMYVYFY-------DIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPS 216 ++G L + GM V Y D E + G + +LL +SD VS+HVP P Sbjct: 154 RRVGELGRAFGMTVVAYDPFLKPEDFEKEHATG-----MGIDELLKVSDFVSIHVPLTPE 208 Query: 217 TKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPA----T 272 TK++ AK I+ MK ++++N SRG +V+ + +AL + + G A DV E A T Sbjct: 209 TKDLFNAKSIAEMKDDAVVLNMSRGGIVNEKDMYEALKAGKIGGYATDVMENELAGSGLT 268 Query: 273 NSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKL 312 +D F SPL E DN +++PHIG + +A ++IG+ + K+ Sbjct: 269 GNDTFASPLFECDNFIVSPHIGAQSVDASKDIGIHIIAKV 308 >UniRef50_B9L1V2 Glyoxylate reductase n=2 Tax=Thermomicrobia (class) RepID=B9L1V2_THERP Length = 333 Score = 172 bits (436), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 104/266 (39%), Positives = 146/266 (54%), Gaps = 14/266 (5%) Query: 42 LDDEQLKESIRDAH--FIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGI 99 +D+EQL E +RD +GL +T V+ A +L I +G + +D+ A +RGI Sbjct: 48 VDEEQLCELVRDVDGLVVGLEP---ITARVLAHANRLKVISTSGVGFDNIDVAEATRRGI 104 Query: 100 PVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGY 159 V N +N SVAEL G +L L RG+ ++ G W E GK LG+IG Sbjct: 105 VVANCHGANEHSVAELAFGLMLALARGIHRSDRLMREGRWEPYFG--VELWGKTLGVIGL 162 Query: 160 GHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQH--LSDLLNMSDVVSLHVPENPST 217 G G + +L GM V +DI NA ++ + L LL SD VSLHVP P T Sbjct: 163 GRAGRAVALLGRGFGMRVLAHDIVWDTTFANAHEISYVPLEKLLRESDFVSLHVPLTPDT 222 Query: 218 KNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPF 277 + ++ + +SLMKP + LIN +RG VV AL +AL +AGA +DVF EP + Sbjct: 223 RYLIDERALSLMKPTAFLINLARGPVVKQSALVEALRRGQIAGAGLDVFEVEPIRD---- 278 Query: 278 TSPLCEFDNVLLTPHIGGSTQEAQEN 303 +P EF+NV++TPH+GGST+EA+E Sbjct: 279 -NPFVEFENVVMTPHLGGSTEEARER 303 >UniRef50_Q5SZU1 Phosphoglycerate dehydrogenase n=11 Tax=Eutheria RepID=Q5SZU1_HUMAN Length = 499 Score = 172 bits (436), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 102/278 (36%), Positives = 146/278 (52%), Gaps = 7/278 (2%) Query: 51 IRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTR 110 ++D + +RS T +T DVINAAEKL +G G + VDL+AA ++GI V N P N+ Sbjct: 11 LQDCEGLIVRSATKVTADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSL 70 Query: 111 SVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILA 170 S AEL G ++ L R +P+A A G W + E GK LGI+G G IG ++ Sbjct: 71 SAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRM 130 Query: 171 ESLGMYVYFYD--IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISL 228 +S GM YD I ++ Q L ++ + D +++H P PST ++ + Sbjct: 131 QSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQ 190 Query: 229 MKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVL 288 K G ++N +RG +VD AL AL S AGAA+DVF EP P L + +NV+ Sbjct: 191 CKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEP-----PRDRALVDHENVI 245 Query: 289 LTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVN 326 PH+G ST+EAQ G E+A + + S VN Sbjct: 246 SCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVN 283 >UniRef50_C2D1B3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Lactobacillus RepID=C2D1B3_LACBR Length = 327 Score = 172 bits (436), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 101/268 (37%), Positives = 156/268 (58%), Gaps = 9/268 (3%) Query: 64 HLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLL 123 H+ E V++ L I +G + +DLDA+A+ G+ V N P +N +VAE + E+ L Sbjct: 66 HVGEAVLSQMPNLKIIARHGVGYDSIDLDASAQHGVWVTNTPNANAATVAETTLAEIFDL 125 Query: 124 LRGVPEANAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI 182 + V +A+++ +G + LA F+ GK LGIIGYGHIG Q+ A +L M + Y+ Sbjct: 126 SKNVTKASSEMRKGNYTYALAHRGFDLAGKTLGIIGYGHIGQQVAKKASALDMPILIYNR 185 Query: 183 ENK-LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 K P G + L LL +D+V+LH+ NP+T +++G +++ MK S+LIN RG Sbjct: 186 SKKESPYG---KFVDLDTLLKTADIVTLHLASNPATHHIIGKDQLAEMKRSSVLINLGRG 242 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 ++D AL +AL + +AGAA+DVF EP P S L +FDNVLLTPHIG ST E+ Sbjct: 243 GLIDTSALINALKTHQIAGAALDVFEEEPL----PLDSDLFQFDNVLLTPHIGSSTVESF 298 Query: 302 ENIGLEVAGKLIKYSDNGSTLSAVNFPE 329 + ++ A ++++ + VN P+ Sbjct: 299 SRMAVDAASEVVRVLNGEKPQWPVNEPK 326 >UniRef50_Q1J0H2 D-3-phosphoglycerate dehydrogenase n=8 Tax=Deinococci RepID=Q1J0H2_DEIGD Length = 542 Score = 171 bits (433), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 107/285 (37%), Positives = 160/285 (56%), Gaps = 12/285 (4%) Query: 60 RSRTHLTEDVINAA-EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIG 118 RSRT + +++ AA ++L IG +G + +DL+A ++RGI V NAP SN S AEL I Sbjct: 61 RSRTKVDRELLEAAGDRLKVIGRGGVGVDNIDLEACSRRGILVLNAPESNNVSAAELAIM 120 Query: 119 ELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVY 178 LL RG+ ++ K G W++ G E + K LGI+G G IG+ + A+ L + V Sbjct: 121 HLLAAARGLTRSDRKTRAGEWDRKFLG-VELKDKTLGIVGLGRIGSIVADRAQGLRLKVV 179 Query: 179 FYDI---ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLL 235 YD ENK + L +LL D +++H P T M+GA+E++L+K G+++ Sbjct: 180 AYDPYVPENKFERLGVERAATLDELLTRVDFLTVHTPLTEETNGMIGARELALLKRGAIV 239 Query: 236 INASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGG 295 +NA+RG +V AL +AL S HL A +DVF EP PF S N+ +T H+G Sbjct: 240 VNAARGGIVQEAALVEALQSGHLFAAGVDVFVEEPPAPDHPFLSA----PNLGITAHLGA 295 Query: 296 STQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEV---SLPLHGG 337 +T EAQE +G E+ G+++ + AVN P + +L L GG Sbjct: 296 NTFEAQERVGAEIVGRVLAALHGDVSKGAVNAPALDAKTLELLGG 340 >UniRef50_B3DVF6 Phosphoglycerate dehydrogenase and ACT domains n=2 Tax=Verrucomicrobia RepID=B3DVF6_METI4 Length = 531 Score = 170 bits (431), Expect = 8e-41, Method: Compositional matrix adjust. Identities = 114/326 (34%), Positives = 170/326 (52%), Gaps = 18/326 (5%) Query: 13 FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINA 72 L+ + + +K + L+A+ ++ K L +++L I D + +RS+T +T VI A Sbjct: 7 ILIADPISKKGIAELQASAQLIVD-EKYGLKEDELARVIADYDGVIVRSQTKITRKVIEA 65 Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA 132 +KL IG +G + VD+DAA ++GI V N P NT + AE LL L R V +A+A Sbjct: 66 GKKLKVIGRAGVGIDNVDVDAATEKGIVVMNTPGGNTIATAEHTFSLLLALARNVAQAHA 125 Query: 133 KAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNAT 192 G W + E GK LGIIG G +G ++ A + GM V +D P + T Sbjct: 126 SMQLGEWKRKNFEGIELYGKILGIIGLGRVGMEVAKRALAFGMKVKCFD-----PYLSPT 180 Query: 193 QVQHLS--------DLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 +V++L +L D +SLHVP T+ ++ + K G +IN +RG ++ Sbjct: 181 KVKNLQVELVNSLDELFQDIDFLSLHVPLTQETEGIINKDNLKKCKRGIRIINCARGGLI 240 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 I L + L S +AGAA+DV+ EP P PL NV+LTPH+ ST EAQEN+ Sbjct: 241 RIADLEELLKSGWVAGAALDVYEPEPP----PADFPLRGLPNVVLTPHLAASTIEAQENV 296 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEV 330 G E+A +I + +AVN P V Sbjct: 297 GTEIAAMVIDVLCHNIIRNAVNVPSV 322 >UniRef50_Q5HNI1 D-3-phosphoglycerate dehydrogenase n=73 Tax=Staphylococcus RepID=Q5HNI1_STAEQ Length = 531 Score = 170 bits (431), Expect = 8e-41, Method: Compositional matrix adjust. Identities = 106/324 (32%), Positives = 173/324 (53%), Gaps = 10/324 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + + L+S+ +++ L + L I + +RS+T +TE +IN Sbjct: 4 KILVSDPISEDGLQSILKHPEFDVDIQTD-LSENDLVNMISTYDALIVRSQTQVTERIIN 62 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AA L I +G + ++++AA +GI V NAP NT S E + LL + R +P+A+ Sbjct: 63 AATNLKVIARAGVGVDNINIEAATLKGILVINAPDGNTISATEHSVAMLLAMARNIPQAH 122 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD---IENKLPL 188 WN+ A E GK LG+IG G IG + A+S GM + +D E+K Sbjct: 123 QSLRNKEWNRKAFRGVELYGKTLGVIGAGRIGLGVAKRAQSFGMKILAFDPYLTEDKAKS 182 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + Q+ + ++ SD V++H P P T+ ++G+ + K +IN +RG ++D A Sbjct: 183 LD-IQIATVDEIAEKSDFVTVHTPLTPKTRGIVGSSFFNKAKQNLQIINVARGGIIDETA 241 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +AL + + AAIDVF EP P SPL + D +++TPH+G ST EAQE + + V Sbjct: 242 LIEALDNNLIDRAAIDVFEHEP-----PTDSPLIQHDKIIVTPHLGASTVEAQEKVAVSV 296 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSL 332 + ++I+ G+ AVN P++ L Sbjct: 297 SEEIIEILTKGNVEHAVNAPKMDL 320 >UniRef50_C9LMC8 Phosphoglycerate dehydrogenase n=1 Tax=Dialister invisus DSM 15470 RepID=C9LMC8_9FIRM Length = 530 Score = 170 bits (430), Expect = 9e-41, Method: Compositional matrix adjust. Identities = 106/300 (35%), Positives = 159/300 (53%), Gaps = 8/300 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K + V ++A E L +I + +D+++L + I + + RS+T +T++VI+ Sbjct: 3 KIFITADVAKEAKEFLEKEFVVDI---RPNMDEDELCKVIGEYDAVITRSQTKITKNVIH 59 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AA L IG +G + +D+ A +GI V N P SNT + E + +L + R +P+A+ Sbjct: 60 AATNLKVIGRAGVGIDGIDIPEATAKGITVVNTPESNTIAACEHTLALMLSITRYIPQAH 119 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 G W++ + + K +GIIG G +G+ + ++ M YD L G Sbjct: 120 QSIMEGRWDRKSFTGIQLLNKTVGIIGVGRVGSNVAKRLQAFNMKTIGYDPYIPLERGQQ 179 Query: 192 TQVQ--HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 V L LL SD ++LH P TK M+GAKEI MK G ++NASRG V+DI AL Sbjct: 180 LGVDLVDLDTLLRESDYITLHTPLTEETKGMIGAKEIEKMKDGVRIVNASRGAVIDIDAL 239 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 +AL + +AGA IDV+ EP P +P NV LTPH+G ST EAQ + +VA Sbjct: 240 AEALKTGKVAGAGIDVWTNEPL---KPENNPFLGMKNVTLTPHLGASTVEAQTGVATDVA 296 >UniRef50_C0GLG9 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Desulfovibrionales RepID=C0GLG9_9DELT Length = 394 Score = 170 bits (430), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 123/380 (32%), Positives = 193/380 (50%), Gaps = 19/380 (5%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 ++ L +G+ +A+ LR G++ ++ K D E L + D + +RS T + ++I Sbjct: 1 MRILANDGLVDEAVNFLRREGFS-VDTEK--RDYEDLLGDLPDFDALLVRSATKVNRELI 57 Query: 71 NAAE----KLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 AA KL IG +GT+ +DL AA + G+ V AP N + AE VIG + + R Sbjct: 58 EAATTKRGKLKIIGRGGVGTDNIDLQAAKECGVVVKFAPHGNINATAEHVIGLMFAIARK 117 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL 186 VP A+ G+W+K E +GK LG+IG G IG + A+ L M V +D++ + Sbjct: 118 VPFAHHTLKSGIWHKARFKGVELQGKTLGLIGCGRIGQAVANKAKDLDMKVIGFDMQRWM 177 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + + ++L+ +D VS++ ++ E+ MK + LINASRG V+ Sbjct: 178 D-SEVDYMDSMEEVLDHADFVSINTG---GAHTLIREPELERMKSSAFLINASRGVNVEE 233 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL AL + +AGAA+D + EP +PFTS L E DN++L+ H+G ST A G+ Sbjct: 234 DALYYALKNGRIAGAALDCYEKEPKREGEPFTSKLAELDNIVLSAHLGASTANAARKTGM 293 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHI---HENRPGVLTALNKIFAEQGV 363 E+A + KY G +VN + + G L I HE++PG+ F + GV Sbjct: 294 EIADVVSKYLKYGDFRQSVNVGQTVID--EGIDLYTIFITHEDKPGMFGKFGTAFGDLGV 351 Query: 364 NIA---AQYLQTSAQMGYVV 380 NI ++ L AQ Y + Sbjct: 352 NIQENNSRRLDGLAQTIYTI 371 >UniRef50_A9BJ57 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=5 Tax=Thermotogaceae RepID=A9BJ57_PETMO Length = 310 Score = 169 bits (429), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 97/285 (34%), Positives = 154/285 (54%), Gaps = 7/285 (2%) Query: 34 NIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDA 93 ++E L+ + LK+ I++ + +RS T +T++++ A+KL + +G + +D+D Sbjct: 23 DLEITSEHLEKDVLKDKIKEIDVLIVRSATKVTKEILEHADKLKIVARAGMGLDNIDVDT 82 Query: 94 AAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKK 153 A +GI V N P N+ SVAELVIG +L + R + W K FE K Sbjct: 83 AKLKGITVLNTPGQNSLSVAELVIGMVLDIYRHITRGTIGLKNEQWEKKQLEGFELSQKT 142 Query: 154 LGIIGYGHIGTQLGILAESLGMYVYFYDI----ENKLPLGNATQVQHLSDLLNMSDVVSL 209 GIIG+G++G L L + YD+ + N QV L +LL SD++SL Sbjct: 143 FGIIGFGYVGKNLAQLLKGFQTNTLVYDVFEISAEEQKNYNVRQVS-LEELLQNSDIISL 201 Query: 210 HVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTE 269 H+P+N T + + +I +MK G+++INA+RG V+D + L + L G +DVF E Sbjct: 202 HIPKNEKTYHFISEPQIKMMKDGAVIINAARGGVLDENYVLKYLKNGKLLGVGLDVFEEE 261 Query: 270 PATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIK 314 P F L NV+LTPHIG ST+EAQE +G+ + ++++ Sbjct: 262 PPKGD--FYKELFALPNVVLTPHIGASTKEAQERVGINIVDRVVE 304 >UniRef50_A9A1H5 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=4 Tax=Archaea RepID=A9A1H5_NITMS Length = 310 Score = 169 bits (428), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 110/277 (39%), Positives = 156/277 (56%), Gaps = 16/277 (5%) Query: 45 EQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNA 104 EQ+ E I D + + +RSRT +T+++I+ A+ I +G + VD +AA + I V NA Sbjct: 37 EQILEKISDYNIVIVRSRTTITKEMIDKADNCKIIARVGVGLDNVDQEAAKAKNIRVINA 96 Query: 105 PFSNTRSVAELVIGELLLLLRGVPEANAKAHRGV----WNKLAAGSFEARGKKLGIIGYG 160 +VAELV+G +L L R A+ RG+ W K E GK LGI+G G Sbjct: 97 VEGAMNAVAELVLGLMLSLAR----QTARGDRGIRNEQWLKKELKGTELAGKYLGIVGLG 152 Query: 161 HIGTQLGILAESLGMYVYFYD---IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPST 217 +IG +LG LA +L M + YD I+ + L+ LL +D VS+HVP ST Sbjct: 153 NIGKRLGRLARALNMNIIGYDVVPIDEEFSKEVGLMKADLNTLLQSADYVSIHVPLLDST 212 Query: 218 KNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPF 277 +++ A+++S MK + +IN SRG VVD AL DAL + L GAA+DVF EPA Sbjct: 213 YHLLDAQKMSTMKKTAKIINTSRGGVVDEDALYDALKNGTLGGAALDVFEKEPA-----I 267 Query: 278 TSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIK 314 + L E DNV+LTPHIG T+EAQ +A K+++ Sbjct: 268 GTKLAELDNVILTPHIGAQTKEAQSLAANVIAEKIVQ 304 >UniRef50_A5IMH3 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=7 Tax=cellular organisms RepID=A5IMH3_THEP1 Length = 308 Score = 169 bits (428), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 101/277 (36%), Positives = 149/277 (53%), Gaps = 11/277 (3%) Query: 42 LDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPV 101 L+ ++L + I + + +RS T +T D+I A + L I IG + +D+ A ++GI + Sbjct: 35 LEKDELMKIIPEIDVLVVRSATKVTADIIEAGKNLKIIARAGIGLDNIDVQKAKEKGIKI 94 Query: 102 FNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGH 161 N P ++ SVAEL +G +L R + A G W K A E GK LG+IG+G+ Sbjct: 95 LNTPGASAPSVAELAMGLMLACARHIARATISLKEGKWEKKALNGKELLGKTLGLIGFGN 154 Query: 162 IGTQLGILAESLGMYVYFYDIENKLPLGNATQVQ----HLSDLLNMSDVVSLHVPENPST 217 IG ++ A + GM + YD P AT + L L SD +SLHVP ST Sbjct: 155 IGQEVAKRALAFGMKIIAYD-----PAKPATDLPVEYVDLDTLFRESDFISLHVPLTEST 209 Query: 218 KNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPF 277 ++++ + I+ MK G +++N +RG +D AL +AL S + A +DVF EP T D Sbjct: 210 RHIINRESIAKMKDGVIIVNTARGGTIDEEALYEALVSGKVYAAGLDVFEVEPPT--DEI 267 Query: 278 TSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIK 314 L DNV+ TPHIG ST EAQ +G E+ K+ K Sbjct: 268 RRKLLNLDNVVATPHIGASTDEAQNRVGTELVEKIFK 304 >UniRef50_A6C2G1 Phosphoglycerate dehydrogenase (SerA) n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C2G1_9PLAN Length = 316 Score = 169 bits (427), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 107/263 (40%), Positives = 145/263 (55%), Gaps = 11/263 (4%) Query: 47 LKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPF 106 LK+ I++ + +R++T + ++I+AA +L I G + VD + A ++GI V P Sbjct: 37 LKQKIQNTRALIVRNQTKVDRELIDAAPELKIIARAGAGLDNVDTEYAHEKGIVVCFTPD 96 Query: 107 SNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQL 166 +N+ SVAEL IG +L L+R +PEA G WN+L E GK G+IG G IG+ Sbjct: 97 ANSLSVAELTIGLMLALMRKIPEARQDTLTGGWNRLKFTGTELYGKSFGLIGLGRIGSFT 156 Query: 167 GILAESLGMYVYFYDIENK-----LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMM 221 A++ GM + D K L NAT + L DLL SDVVS H P P T+ M+ Sbjct: 157 ATRAKAFGMNILAADPFLKADAPQLKKLNATLLS-LDDLLAESDVVSCHSPLTPDTRKML 215 Query: 222 GAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPL 281 + MKP + IN SRG VVD L AL LAGAA+DV TEP P SPL Sbjct: 216 TYQHFRKMKPDAFFINTSRGEVVDERGLTQALLEHKLAGAALDVRETEP-----PKQSPL 270 Query: 282 CEFDNVLLTPHIGGSTQEAQENI 304 + +NV+LTPHI T EAQ+ + Sbjct: 271 NQMENVILTPHIAAFTVEAQDRV 293 >UniRef50_C4V410 Phosphoglycerate dehydrogenase n=4 Tax=Veillonellaceae RepID=C4V410_9FIRM Length = 565 Score = 169 bits (427), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 109/328 (33%), Positives = 170/328 (51%), Gaps = 12/328 (3%) Query: 7 EKDKIKFLLVEGVHQKALESLRAAGYTNIEFH-KGALDDEQLKESIRDAHFIGLRSRTHL 65 E ++K L +G+ + + L T+ E + + E+L + I D + +RS + + Sbjct: 36 EGIRMKILAADGISPEGIGLL-----TDYEVDVRDKISHEELLDVIGDYDALMVRSASKV 90 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 T DV+ A KL IG +G + +D+ AA +RGI V N+P NT + E + +L + R Sbjct: 91 TADVLERAGKLKIIGRAGVGVDNIDVKAATERGIIVINSPGGNTIAATEHTVAMMLAMAR 150 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IE 183 +P A+A H G WN+ A E RGK LG+IG G IG + A + M V YD I Sbjct: 151 NIPTADATMHAGQWNRKAYVGVELRGKTLGVIGMGRIGGGVAKRALAFDMNVIAYDPYIN 210 Query: 184 NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 + V L D++ +D +++H+P T+ M+ ++ MK G L+N +RG + Sbjct: 211 EERAKALGVTVGTLDDIIEQADFITVHMPLTKETRGMISMAQMRRMKQGVRLVNCARGGI 270 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 ++ L +A+ +AGAAIDVF +EP SPL ++LTPH+G ST EAQ Sbjct: 271 INEHDLAEAVREGIVAGAAIDVFESEPLAED----SPLRSVPGIVLTPHLGASTVEAQIG 326 Query: 304 IGLEVAGKLIKYSDNGSTLSAVNFPEVS 331 + ++VA + L+AVN VS Sbjct: 327 VSVDVAKGICAALRGEPVLAAVNMAPVS 354 Score = 41.6 bits (96), Expect = 0.058, Method: Compositional matrix adjust. Identities = 29/103 (28%), Positives = 52/103 (50%), Gaps = 4/103 (3%) Query: 307 EVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIA 366 EV G L + + G + +N V + H R L+ H NRPGV+ + I G+NI+ Sbjct: 462 EVQGAL--FGEEGRIVR-INRFRVDVDPHA-RILICPHINRPGVIGTIGSIMGAAGINIS 517 Query: 367 AQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 + + S + G ++ + D D+++ L + A+ G A+L+ Sbjct: 518 SMQVGKSDRKGMNIMVLTIDHDISDDVLARVLAVEGIFDAKLV 560 >UniRef50_A4YUP8 Putative D-3-phosphoglycerate dehydrogenase (PGDH) n=4 Tax=Proteobacteria RepID=A4YUP8_BRASO Length = 335 Score = 169 bits (427), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 93/244 (38%), Positives = 143/244 (58%), Gaps = 6/244 (2%) Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 + + VI A++KL AI +G + +D++AA +RGIPVF A +N++SVAEL + + Sbjct: 67 IDDQVIGASQKLKAIAKHGVGYDNIDVEAADRRGIPVFVARGANSQSVAELAFALMFAVA 126 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--I 182 R +P +A+ G W+K + G+ LG+IG+G IG L L + L M V +D + Sbjct: 127 REIPHLDARIKTGHWDKATTKGAQLLGRSLGVIGFGEIGRILVGLVQPLHMEVRIFDPYM 186 Query: 183 ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 + A + L ++L SDV+SLH P P T+NM+G +++ M+ ++LIN +RG Sbjct: 187 PADAEISGAERAGSLDEILTASDVISLHCPLMPQTRNMIGRDQLARMRRNAILINTARGG 246 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 ++D AL DAL +AGA +D F EPA PL NV++TPH G STQEA++ Sbjct: 247 LIDEAALYDALRDGVIAGAGLDSFAEEPAKPD----LPLLALSNVVVTPHAGASTQEARD 302 Query: 303 NIGL 306 +G+ Sbjct: 303 AMGV 306 >UniRef50_Q3SK87 D-isomer specific 2-hydroxyacid dehydrogenase n=13 Tax=Bacteria RepID=Q3SK87_THIDA Length = 391 Score = 168 bits (426), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 118/354 (33%), Positives = 182/354 (51%), Gaps = 35/354 (9%) Query: 75 KLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR--------- 125 + AIG GTN + + ++RG+PVFNAP +N +V ELVI +L+ R Sbjct: 52 SVCAIGRAGAGTNNIPVKKMSERGLPVFNAPGANANAVKELVIAGMLMGARNLVPALKFV 111 Query: 126 ----GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD 181 G EA KA + A E G+ LG+IG G IG+ + A LGM V YD Sbjct: 112 ESLDGTDEAMHKATEAGKKQFA--GMELPGRTLGVIGLGAIGSHIAEAAIRLGMNVVGYD 169 Query: 182 ------IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLL 235 +LP + +++ D+L +D V+LHVP +T+N++ A+ +SLM+ G++L Sbjct: 170 PAITVDAAWRLP-SQVKRAENVDDVLRTADFVTLHVPLLDATRNLINAQRLSLMRSGAVL 228 Query: 236 INASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGG 295 +N +R VVD A+ +AL + L D FP A P V+ PH+G Sbjct: 229 LNFAREGVVDNAAVIEALDAGKLHAYICD-FPAN-ALKGHP---------KVVALPHLGA 277 Query: 296 STQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALN 355 ST+EA+EN + VA +L Y +NG+ L++VNFP V++P RL + N P ++ ++ Sbjct: 278 STEEAEENCAVMVAEQLTDYLENGNILNSVNFPSVAMPRESAFRLAIANANVPNMVGQIS 337 Query: 356 KIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 + A G+NI ++ M Y ++D+ D VA + + AI G + R L Sbjct: 338 SVLAAAGLNIHNMVNKSKGDMAYTLVDV--DSAVAGSVIAQLNAIGGVLGVRYL 389 >UniRef50_D2C7W6 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Thermotoga naphthophila RKU-10 RepID=D2C7W6_THENR Length = 329 Score = 166 bits (421), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 112/299 (37%), Positives = 168/299 (56%), Gaps = 16/299 (5%) Query: 21 QKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIG 80 ++ ++ L G+ + K +E+L+E+I+DA + + + T +T ++I ++ L I Sbjct: 16 KEPIDYLERNGFVVLRVEK----EEELREAIKDAEALIVGTHT-VTREMIESS-NLKVIA 69 Query: 81 CFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKA-HRGVW 139 +G + +D++AA ++GIPV +N+ SVAEL I + L RG+ A+ K + W Sbjct: 70 KHGVGVDNIDVEAATEKGIPVTITLGANSLSVAELTIAFIFALSRGLIWAHNKLFYEKKW 129 Query: 140 NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD---IENKLPLGNATQVQH 196 E GK +G+IG+G IG ++ A LGM V YD ++ + L AT V Sbjct: 130 EGYVGQ--EVSGKVMGVIGFGSIGREVVKKAVCLGMNVLVYDPYVSKDSVRLLEATPVDD 187 Query: 197 LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASK 256 L LL SD VSLHVP N STKNM+G +E+SLMK + LIN SRG +VD AL AL Sbjct: 188 LEQLLKESDFVSLHVPLNESTKNMIGERELSLMKKSAFLINTSRGELVDEEALVKALKEG 247 Query: 257 HLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKY 315 +AGAA+DVF EP + SPL E N++ T HIG T+EA + + A ++ + Sbjct: 248 RIAGAALDVFSEEPPDAN----SPLFECPNLITTAHIGAHTKEAIFRMNMMAAQSIVDF 302 >UniRef50_C7MMC6 Phosphoglycerate dehydrogenase-like oxidoreductase n=1 Tax=Cryptobacterium curtum DSM 15641 RepID=C7MMC6_CRYCD Length = 387 Score = 166 bits (421), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 124/389 (31%), Positives = 187/389 (48%), Gaps = 44/389 (11%) Query: 43 DDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVF 102 D +L +SI DA + ++ T + N L+AIGC LD KRGI VF Sbjct: 20 DTYELVQSINDAEALLIQDALLDTTPLPNG---LLAIGCAGAKIAPALLDECTKRGIAVF 76 Query: 103 NAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGS---------------- 146 + P +N +V EL + +LL R + E A W + A S Sbjct: 77 DTPRANANAVKELALCAMLLSSRNILEGAA------WCREHAQSPTLTQDANAVKDCFMG 130 Query: 147 FEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNAT----QVQHLSDLLN 202 E G+ +G+IG G +G QL A +LGM VY YD +A +V L +L Sbjct: 131 HEIAGRNVGVIGLGAVGGQLVRSAVALGMNVYGYDPYVARTSADAQAGIHRVTDLEELCA 190 Query: 203 MSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAA 262 + D + + VP + +T++++G EI+ MKPG+ LIN S V+D AL DAL ++H+ Sbjct: 191 VCDYLVVRVPASTATQSLIGEAEIAAMKPGATLINLSACEVIDTAALADALEAQHIKCYF 250 Query: 263 IDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTL 322 D FPT+ A + ++ PH+G ST EAQE+ +++ Y D GS Sbjct: 251 TD-FPTQEAL----------ALPHTIVLPHLGDSTVEAQESCACAAVREVVSYIDEGSIE 299 Query: 323 SAVNFPEVSLPL--HGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVV 380 +++NFP V P+ G R+ +H NRP ++ + AE G NI+ + + Y + Sbjct: 300 NSLNFPAVQAPVLPEGAGRIALLHTNRPNMVGQITAALAEAGANISHLMNASRNEAAYTL 359 Query: 381 IDIEADEDVAEKALQAMKAIPGTIRARLL 409 ID DE V + L ++AI G R R + Sbjct: 360 ID--TDESVGKVPLDQLRAIEGVWRLRTI 386 >UniRef50_Q2S4S4 D-3-phosphoglycerate dehydrogenase n=2 Tax=Rhodothermaceae RepID=Q2S4S4_SALRD Length = 512 Score = 166 bits (419), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 104/296 (35%), Positives = 155/296 (52%), Gaps = 18/296 (6%) Query: 45 EQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNA 104 E+L++ D I RS+ + E V+ A++ L A+ CIG + VD A A G+ V N Sbjct: 119 ERLRQGQHD--LIYKRSKFVVDEHVVQASDNLAAVMLCCIGDDTVDKQACADEGVLVLND 176 Query: 105 PFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGT 164 P SN RSV E+V+GE+++L R + AN R +W K + +E K L +IG G+IG Sbjct: 177 PVSNGRSVVEMVMGEMVVLARRLYTANETGRRHLWTKDSTRRYELMDKTLSVIGLGNIGK 236 Query: 165 QLGILAESLGMYVYFYD-----IENKLPLGNATQVQHLSDLLNMSDVVSLHVP-ENPSTK 218 QL LA++ GM + FYD E LG T L++ D V++HV E+P + Sbjct: 237 QLARLADAFGMNIRFYDEADVAREVGTTLG-WTSCSSLAEAFRKGDFVTVHVSAEDPQGQ 295 Query: 219 NMMGA------KEISLMKPGS---LLINASRGTVVDIPALCDALASKHLAGAAIDVFPTE 269 G +++ +P + INA+RG + D L A+ H+ AA+DVFP E Sbjct: 296 PNSGLLDYSHFRQLGADRPDNSPRAFINAARGFLYDPADLKRAIDEDHVRAAAVDVFPEE 355 Query: 270 PATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAV 325 P + + +T+P E DNV TPHIG +TQEAQ I ++ ++ G+ V Sbjct: 356 PGSADEDWTNPYAEMDNVFTTPHIGAATQEAQPRIASRMSTSTRLLNEQGTVRDTV 411 >UniRef50_Q01W77 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q01W77_SOLUE Length = 312 Score = 166 bits (419), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 101/268 (37%), Positives = 148/268 (55%), Gaps = 12/268 (4%) Query: 44 DEQLKESIRDAHF-IGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVF 102 ++ L E +R+A + +RS + TE V A KL + + GT+ VDL AAA+ G+ V Sbjct: 39 EDLLIERLREAEVALNIRSSSRFTERVFAACPKLRMVSIWGTGTDHVDLAAAARHGVTVA 98 Query: 103 NAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHI 162 N P RS+AE + L + R +P +A RG W + S E GK G+IGYG + Sbjct: 99 NTPGVAARSIAEHTLALLFAVARQIPHMDAATRRGAWER--GQSMELYGKTCGVIGYGAV 156 Query: 163 GTQLGILAESLGMYVYFYDIE-NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMM 221 G LA ++GM V + + + P + L DL SDV+S+H+ +P T++ + Sbjct: 157 GRHFARLATAIGMRVMQWTLHPSAYP---DVEFASLEDLYRASDVISVHLRLSPDTQDFI 213 Query: 222 GAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPL 281 A + +LMK ++L+N +RG +V PAL DAL + +LA A +DVF TEP P PL Sbjct: 214 AAPQFALMKSEAILLNTARGAIVSEPALLDALIAGNLAAAGLDVFTTEPL----PPNHPL 269 Query: 282 CEFDNVLLTPHIGGSTQEAQENIGLEVA 309 NV+LTPH G T EA + GL++A Sbjct: 270 TTLPNVVLTPHCAGITPEAL-HAGLQLA 296 >UniRef50_A4FIF2 D-3-phosphoglycerate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FIF2_SACEN Length = 316 Score = 166 bits (419), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 112/294 (38%), Positives = 157/294 (53%), Gaps = 15/294 (5%) Query: 21 QKALESLRAAGYTNIEFHKG---ALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLV 77 ++ E L AAG + H+ DD + DA +G+ +T +VI A +L Sbjct: 16 REPWEILEAAGSAAVRPHETRAMPADDLLARVPEADALIVGM---DLVTAEVIEAGPRLR 72 Query: 78 AIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRG 137 I +G + +DLDAA RGIPV AP SN+R+VAEL G ++ R + A+ G Sbjct: 73 VIAKHGVGVDNIDLDAARARGIPVVFAPGSNSRAVAELTFGLMIAAARRIAAAHTAVVAG 132 Query: 138 VWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IENKLPLGNATQVQ 195 W KL E G+ LG+IG+G IG L A++ GM V YD +++ + Sbjct: 133 DWPKLYGP--ELAGRTLGVIGFGRIGRLLAGYAQAFGMTVVGYDPFLDDGELTERGVRPV 190 Query: 196 HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALAS 255 S+ L MSD VSLH+P P ++ + + MKPG+ L+NA+RG +VD AL + L S Sbjct: 191 SFSECLAMSDFVSLHLPAEPGRPPLLDQRALRTMKPGACLVNAARGGLVDESALAELLHS 250 Query: 256 KHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 HL AA D F TEP +S T+P NVLLTPHIG + EA ++G+ VA Sbjct: 251 GHLGAAACDAFATEPLADSPLRTAP-----NVLLTPHIGACSHEANRDMGVMVA 299 >UniRef50_Q1PZY1 Similar to D-3-phosphoglycerate dehydrogenase (PGDH) n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PZY1_9BACT Length = 535 Score = 165 bits (418), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 106/279 (37%), Positives = 151/279 (54%), Gaps = 8/279 (2%) Query: 37 FHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAK 96 K L +L I+ + +RS T LT V+ +EKL AI +G + +D+ AA K Sbjct: 34 LKKTGLKPPELDAVIKMCDGVIVRSNTKLTAPVLEKSEKLKAICRAGVGVDNIDVPAATK 93 Query: 97 RGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGI 156 +GI V N P N S AE I L L R VP+A A G W K + GK GI Sbjct: 94 KGIVVMNTPAGNIISTAEHTIALLCSLSRFVPQACASVKEGKWEKKKFTGQQLTGKTFGI 153 Query: 157 IGYGHIGTQLGILAESLGMYVYFYD--IENKLPLG-NATQVQHLSDLLNMSDVVSLHVPE 213 IG G +G Q+ A +L M V YD I ++ N V++L DLL +D +++HV Sbjct: 154 IGLGRVGRQVAKRAAALEMKVIGYDPFITTEISSQYNIHIVKNLRDLLAQADYITIHVTL 213 Query: 214 NPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATN 273 N TKN++ +KE SLMK G +IN +RG V+ L +A+ + +AGAA+DVF EP Sbjct: 214 NKETKNLITSKEFSLMKKGVQIINCARGGVICEEDLYNAIKTGQVAGAALDVFEEEP--- 270 Query: 274 SDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKL 312 P + L + + V+ TPH+G ST+EAQ + +E A ++ Sbjct: 271 --PKDNKLLQLEEVIATPHLGASTEEAQYAVAIEAAEQM 307 >UniRef50_UPI00016C495D phosphoglycerate dehydrogenase n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C495D Length = 539 Score = 165 bits (417), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 111/324 (34%), Positives = 177/324 (54%), Gaps = 11/324 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEF-HKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + L+ + + +E L+AAG IE ++ L ++LK +I+ A + RS+ L+ + Sbjct: 3 RVLIADKLESSGIELLQAAG---IEVDNRPGLKGDELKAAIQAADAVICRSQPKLSAEYF 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 + K+ A+ +G + +D+ AA ++G+ V N P NT S AE I LL L R +P A Sbjct: 60 DNPGKMRAVARAGVGVDNIDVAAATRKGVVVMNTPGGNTVSAAEHTIALLLALSRRIPAA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD---IENKLP 187 +A G W++ E GK LG++G G IG ++ A+ L M V D K+ Sbjct: 120 DATMKAGGWDRNKFVGTEVAGKVLGVVGLGRIGREVARRAKGLDMKVIALDQFVTAAKVA 179 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 L +LL D ++LHVP TK+M+GA+E+ LMK + ++N +RG ++D Sbjct: 180 ELGYESAASLDELLPKVDYLTLHVPGGAETKSMVGARELGLMKKTARVLNVARGGIIDEK 239 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL +ALA+ +AGA +DVF EP + PL + N+++TPH+G ST EAQEN+ +E Sbjct: 240 ALAEALAAGTIAGAGVDVFSVEPIAADN----PLAKAPNIVITPHLGASTLEAQENVAVE 295 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVS 331 A + + +G +AVN V+ Sbjct: 296 AAQLIKDFLLSGQVANAVNMAAVN 319 >UniRef50_A6C9V4 Phosphoglycerate dehydrogenase n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C9V4_9PLAN Length = 541 Score = 164 bits (414), Expect = 7e-39, Method: Compositional matrix adjust. Identities = 103/301 (34%), Positives = 153/301 (50%), Gaps = 18/301 (5%) Query: 39 KGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRG 98 + L E+++E+++ A I +RS T LTE+V+ +L AI +G + +D AA + G Sbjct: 29 RSGLSPEEVREALKSADGIIIRSATKLTEEVLKGQPRLKAIVRAGVGVDNIDRAAATREG 88 Query: 99 IPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIG 158 I V N P NT S AE I ++ L R + A A G W + + GK L IIG Sbjct: 89 IVVMNTPAGNTTSTAEQTIALMMALARNIGPAYATMKEGKWERKKLTGTQVAGKTLAIIG 148 Query: 159 YGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQV--------QHLSDLLNMSDVVSLH 210 G IG + A+ L M V YD P +A + + + +L+ D +++H Sbjct: 149 LGRIGLSVAHRAQGLEMKVIGYD-----PFMSAERAAEYGIELYKEVDELVKHCDFLTVH 203 Query: 211 VPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEP 270 P T++++ A+ I+ M+PG +IN +RG +V+ L DAL S +AGAA DVF EP Sbjct: 204 TPLTDETRDLINAERIATMRPGVRIINCARGGIVNEDDLADALESGKVAGAACDVFTQEP 263 Query: 271 ATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEV 330 N +P N+L TPH+G ST EAQE + LE A + + A+N V Sbjct: 264 PENRRLIDAP-----NMLATPHLGASTDEAQEMVALEAAEIISDFLTKNEIRHAINMIPV 318 Query: 331 S 331 S Sbjct: 319 S 319 >UniRef50_C1ZMC1 D-3-phosphoglycerate dehydrogenase n=2 Tax=Planctomycetaceae RepID=C1ZMC1_PLALI Length = 546 Score = 162 bits (411), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 110/356 (30%), Positives = 186/356 (52%), Gaps = 20/356 (5%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ + + L+ L+ ++ KG DE ++ ++ DA I +RS T LT +++ Sbjct: 3 RVLITDNLSPAGLKILKETPGIEVDLRKGLTPDE-VRVALHDADGIIIRSETKLTPEILK 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 +L AI +GT+ ++L AA + GI V N P NT S AE I ++ L R + A Sbjct: 62 DQPRLKAIVRAGVGTDNINLPAATREGIVVMNTPAGNTTSTAEHTIAMMMALSRNIAPAA 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD----IENKLP 187 +K GVW++ + + GK + I+G G IG + A L M V +D +E Sbjct: 122 SKLRDGVWDRKSFTGTQLAGKSIAIVGLGRIGLAVARRAMGLEMKVLGFDPFMSVERAAE 181 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 G + + +++ D +++H P +P T N++GA+ ++ MK G +IN +RG +++ Sbjct: 182 QG-IELYRDIDEMITKCDYLTVHTPLSPETTNLIGAERLAKMKKGVRIINCARGGIINEA 240 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 L A+ S H+ GAA+DVF EP P +PL + VL TPH+ ST EAQE + +E Sbjct: 241 ELAQAIESGHIGGAALDVFVKEPT----PPDNPLLKLPQVLCTPHLAASTDEAQELVAVE 296 Query: 308 ----VAGKL----IKYSDNGSTLSAVNFPEVSLPLHGGRRLMHI--HENRPGVLTA 353 +AG L ++++ N + +S+ ++ + L G RL + N+ GV +A Sbjct: 297 AAEIMAGFLVRHEVRHAVNMAPISSAEMADMRIYLDLGLRLGVVLSQLNKSGVRSA 352 >UniRef50_P0A545 D-3-phosphoglycerate dehydrogenase n=57 Tax=Actinomycetales RepID=SERA_MYCBO Length = 528 Score = 162 bits (411), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 97/269 (36%), Positives = 149/269 (55%), Gaps = 7/269 (2%) Query: 43 DDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVF 102 D ++L ++ +A + +RS T + +V+ AA KL + +G + VD+DAA RG+ V Sbjct: 33 DRDKLLAAVPEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVV 92 Query: 103 NAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHI 162 NAP SN S AE + LL R +P A+A W + + E GK +G++G G I Sbjct: 93 NAPTSNIHSAAEHALALLLAASRQIPAADASLREHTWKRSSFSGTEIFGKTVGVVGLGRI 152 Query: 163 GTQLGILAESLGMYVYFYD--IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNM 220 G + + G YV YD + ++ L DLL +D +S+H+P+ P T + Sbjct: 153 GQLVAQRIAAFGAYVVAYDPYVSPARAAQLGIELLSLDDLLARADFISVHLPKTPETAGL 212 Query: 221 MGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSP 280 + + ++ KPG +++NA+RG +VD AL DA+ H+ A +DVF TEP T+ SP Sbjct: 213 IDKEALAKTKPGVIIVNAARGGLVDEAALADAITGGHVRAAGLDVFATEPCTD-----SP 267 Query: 281 LCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 L E V++TPH+G ST EAQ+ G +VA Sbjct: 268 LFELAQVVVTPHLGASTAEAQDRAGTDVA 296 >UniRef50_Q8XPB1 D-3-phosphoglycerate dehydrogenase n=9 Tax=Clostridium perfringens RepID=Q8XPB1_CLOPE Length = 301 Score = 162 bits (410), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 101/301 (33%), Positives = 162/301 (53%), Gaps = 14/301 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 ++ LL +G+ +KA+ +L G+ + D E LKE I+ I +RS T + ++I Sbjct: 2 LRILLNDGLDKKAISNLEFLGF---DVDTNHYDIEDLKEKIKKVDCIVIRSATKIRRELI 58 Query: 71 NAA---EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 + A KL I +G + +D+ A + GI V N P +++ SVAE+++ + L R + Sbjct: 59 DEAIKGGKLKLIIRGGVGVDNIDVQYAEQNGIKVRNTPNASSSSVAEIILAHMFSLARFL 118 Query: 128 PEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP 187 ++N G+W K E GK LGIIG G IG++L +LGM + ++D+ + Sbjct: 119 NQSNITMKAGLWKKKDYVGVELEGKTLGIIGMGRIGSELAKKCTALGMKIIYFDLMDIKN 178 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + N + +LL SD +S+++ TK+++G++E+ +K G +IN SRG +D Sbjct: 179 IDNNYRKVEFDELLRESDFISINI---SGTKSIIGSEELKKVKKGVFIINTSRGKALDEE 235 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 A+ +L L G +DVF EP+ N + P V LTPHIG ST+EAQ IG E Sbjct: 236 AIITSLNDGTLGGVGLDVFLEEPSKNLELINHP-----KVSLTPHIGASTKEAQMKIGEE 290 Query: 308 V 308 V Sbjct: 291 V 291 >UniRef50_A6ULR7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Sinorhizobium medicae WSM419 RepID=A6ULR7_SINMW Length = 328 Score = 162 bits (410), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 97/278 (34%), Positives = 151/278 (54%), Gaps = 7/278 (2%) Query: 44 DEQLKESIRDAHFIGLRSRT-HLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVF 102 + +L ES+R F + SRT L +I A L I +G N VD+++A +RG+PV Sbjct: 35 EAELAESLRSTPFDAVISRTLALPAMMIETAPALRVISRHGVGYNNVDIESATRRGVPVL 94 Query: 103 NAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHI 162 A +N +SVAEL +G L + R + +A WN+ A G + GK GI+ +G I Sbjct: 95 IADGANGKSVAELAVGLALSVARKITTQDASIRARQWNRSAYG-LQFAGKTAGIVAFGAI 153 Query: 163 GTQLGILAESLGMYVYFYDIENK-LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMM 221 G ++ + ++ M + +D + + L +LL SD+VSLH P P T+NM+ Sbjct: 154 GRRVAEILRAMDMRIIAFDPHARDRSTTGVDWTETLDELLQESDLVSLHCPLTPETRNMI 213 Query: 222 GAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPL 281 A ++ MKPG++LIN +RG ++D AL +A+ S HLAGA +D F EP PF S Sbjct: 214 TAPRLARMKPGAILINTARGGLIDEKALAEAVLSGHLAGAGLDTFADEPLPADHPFLS-- 271 Query: 282 CEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNG 319 +++TPH+GGST A + + + A ++ +G Sbjct: 272 --LPQIVMTPHMGGSTDVALDGVAISAARNVLDVLIDG 307 >UniRef50_B8I0H1 D-3-phosphoglycerate dehydrogenase n=13 Tax=Clostridia RepID=B8I0H1_CLOCE Length = 535 Score = 162 bits (409), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 108/327 (33%), Positives = 171/327 (52%), Gaps = 13/327 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K ++ E + + + L+ G+ ++ G + E+L E+I D I +RS T + E+++ Sbjct: 1 MKIIVTERIAEDGINYLKENGH-EVDTRYG-ISHEELLETIEDYDAIIVRSVTKVNEELL 58 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A KL G G + +++ A KRGI V N P SN + AEL +G + R +P+A Sbjct: 59 QRASKLKVAGRAGNGIDNIEVPACTKRGIIVVNTPESNIMAAAELAVGHAYAIFRNIPQA 118 Query: 131 N--AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD---IENK 185 + KA G+ E K GIIG G IG+ + + M V YD + K Sbjct: 119 HWAGKAQNDFRRSRFNGN-ELDEKTAGIIGLGRIGSIVATKLKGSNMKVIAYDPYITDEK 177 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 + L +LL SD++SLH P+ T M+G +++ L K ++NA+RG +V+ Sbjct: 178 FKKLGVERCDTLEELLKQSDLISLHTPKTSETYGMIGEEQLKLCKKDVRIVNAARGGLVN 237 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDP----FTSPLCEFDNVLLTPHIGGSTQEAQ 301 AL +A+ H+A AA+DV EP + P + + L E DNV++TPH+G ST EA Sbjct: 238 EEALYNAIKEGHVAAAALDVLDPEPNYDKKPEDQDYQNKLFELDNVIITPHLGASTAEAN 297 Query: 302 ENIGLEVAGKLIKYSDNGSTLSAVNFP 328 N+G V+ KL+ + G ++AVN P Sbjct: 298 YNVGTAVS-KLVSDALKGEMVAAVNMP 323 >UniRef50_O04130 D-3-phosphoglycerate dehydrogenase, chloroplastic n=43 Tax=Viridiplantae RepID=SERA_ARATH Length = 624 Score = 162 bits (409), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 113/330 (34%), Positives = 175/330 (53%), Gaps = 20/330 (6%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K + L+ E + + + LR G + + L E LK+ + ++ + +RS T +T +V Sbjct: 82 KPRILVTEKLGEAGVNLLREFGDVDCSYD---LSPEDLKKKVAESDALIVRSGTKVTREV 138 Query: 70 INAAE-KLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 AA+ +L +G +G + VDL AA + G V NAP +NT + AE I L + R V Sbjct: 139 FEAAKGRLKVVGRAGVGIDNVDLQAATEHGCLVVNAPTANTVAAAEHGIALLASMARNVA 198 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL 188 +A+A G W + GK L ++G+G +GT++ A+ LGM V +D P Sbjct: 199 QADASIKAGKWERSKYVGVSLVGKTLAVMGFGKVGTEVARRAKGLGMTVISHD-----PY 253 Query: 189 GNATQVQHLS-DLLNM------SDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 A + + L DL++ +D VSLH+P P+TK + + S MK G LIN +RG Sbjct: 254 APADRARALGVDLVSFDQAISTADFVSLHMPLTPATKKVFNDETFSKMKKGVRLINVARG 313 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 V+D AL AL + +A AA+DVF EP + S L + +NV +TPH+G ST+EAQ Sbjct: 314 GVIDEDALVRALDAGIVAQAALDVFCEEPPSKD----SRLIQHENVTVTPHLGASTKEAQ 369 Query: 302 ENIGLEVAGKLIKYSDNGSTLSAVNFPEVS 331 E + +E+A + + +AVN P V+ Sbjct: 370 EGVAIEIAEAVAGALKGELSATAVNAPMVA 399 >UniRef50_D2R855 D-3-phosphoglycerate dehydrogenase n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2R855_9PLAN Length = 542 Score = 162 bits (409), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 107/323 (33%), Positives = 164/323 (50%), Gaps = 11/323 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+++ + Q+ L+ L AA E G L E+LK+S+ + RS +T + + Sbjct: 3 RILILDPIAQEGLDMLAAAPGIEYEVRTG-LKGEELKKSLAEFDGAICRSGVTITAESLE 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 ++ AI +GT+ +D +AA + GI V N P NT S AE +L L R V EA Sbjct: 62 GNRRMRAIARAGVGTDNIDKNAATRLGIVVMNTPTGNTLSTAEHTFTLMLALSRRVAEAY 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD----IENKLP 187 K G W++ + K LGI+G G IG ++ A + M V +D E Sbjct: 122 HKLIGGKWDRKTFMGTQLADKTLGIVGLGRIGQEVAKRAIAFQMKVLGFDPFLSTEQAAK 181 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 LG +V+ + ++L D +++H P P T N++G E+ ++KPG LIN +RG + + Sbjct: 182 LG-IERVETVQEMLPRVDYLTVHTPLTPETTNLVGFPELEVLKPGVRLINCARGGIYNED 240 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL + L + + G A+DVF TEP P+ NVL TPH+G ST+EAQ+ + +E Sbjct: 241 ALVEGLKTGKIGGVALDVFVTEPCDK-----HPIYGMPNVLCTPHLGASTEEAQQQVAIE 295 Query: 308 VAGKLIKYSDNGSTLSAVNFPEV 330 LI + G AVN V Sbjct: 296 AVQLLINFFTTGEVRHAVNMASV 318 >UniRef50_A5IK90 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=6 Tax=Thermotogaceae RepID=A5IK90_THEP1 Length = 327 Score = 162 bits (409), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 116/299 (38%), Positives = 165/299 (55%), Gaps = 18/299 (6%) Query: 21 QKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIG 80 Q+ +E L+ G+ I +D + LKE DA +G T E + N++ K++A Sbjct: 16 QEPVEFLKKEGFEII--RSDTIDPDILKEV--DALIVGTHPVT--AEMIENSSLKVIA-- 67 Query: 81 CFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAH-RGVW 139 +G + +DL+AA K+GIPV +N+ SVAEL I + L+RG+ A+ K W Sbjct: 68 KHGVGVDNIDLEAATKKGIPVTITAGANSLSVAELTIAFIFALIRGLVWAHNKLFLERKW 127 Query: 140 NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD---IENKLPLGNATQVQH 196 E GK LG++G+G IG ++ A LGM V YD ++ + L AT V Sbjct: 128 EGTVGQ--EVSGKTLGVVGFGSIGREVVKKAVCLGMNVLVYDPYVSKDNVRLLEATPVDD 185 Query: 197 LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASK 256 L LL SD VSLHVP N STKNM+G +E+SLMK + LIN SRG +VD AL AL Sbjct: 186 LDQLLKESDFVSLHVPLNESTKNMIGERELSLMKKSAFLINTSRGGLVDEEALVKALKEG 245 Query: 257 HLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKY 315 +AGAA+DVF EP +P SPL + N++ T HIG T+E+ + + A ++ + Sbjct: 246 RIAGAALDVFSEEPP---NP-NSPLFKCPNLITTAHIGAHTKESILRMNMMAAQSVVDF 300 >UniRef50_C3XIZ9 D-3-phosphoglycerate dehydrogenase n=4 Tax=Campylobacterales RepID=C3XIZ9_9HELI Length = 535 Score = 160 bits (406), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 107/303 (35%), Positives = 169/303 (55%), Gaps = 19/303 (6%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K ++ + +H + L+ L ++E + L ++L + A + RS T + E + Sbjct: 2 KKHIIVCDHIHDEGLKILSTQDDISME-NLAHLPKDELLTHLHKADVLITRSSTGVNEKL 60 Query: 70 INAA----EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 + +A +KL AI +G + VD+DA + RG+ V N P +NT + EL + LL +R Sbjct: 61 LESAYKDSKKLKAIVRAGVGVDNVDIDACSYRGVVVMNVPTANTIAAVELTMTHLLSAIR 120 Query: 126 GVPEANA--KAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI- 182 P A+ K R W + E + KKLG+IG+G+IG+++GI A++ M V YD Sbjct: 121 RFPSAHTQLKVERK-WKREDWYGIELKDKKLGVIGFGNIGSRVGIRAKAFDMQVIAYDPY 179 Query: 183 --ENK-LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINAS 239 NK L LG + D+L D++++H P+N T NM+ +KEI+ MK G +LIN + Sbjct: 180 INPNKALDLG-IEYTTNFDDIL-ACDIITIHTPKNKQTTNMITSKEIAKMKDGVILINCA 237 Query: 240 RGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQE 299 RG + + L + L SK +A A +DVF +EPATN + L + DN+ +TPHIG +T E Sbjct: 238 RGGLYNENDLYEGLKSKKIAWAGLDVFDSEPATN-----NKLLDLDNIYVTPHIGANTLE 292 Query: 300 AQE 302 +QE Sbjct: 293 SQE 295 >UniRef50_C5BMJ8 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain protein n=10 Tax=Bacteria RepID=C5BMJ8_TERTT Length = 393 Score = 160 bits (405), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 120/357 (33%), Positives = 186/357 (52%), Gaps = 36/357 (10%) Query: 74 EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA- 132 E ++A+ GTN V +D K G+ VFN P +N +V ELV+ +LL RG+ + Sbjct: 49 ESVIAVARAGAGTNNVPVDEYTKSGVVVFNTPGANANAVKELVLAGMLLSSRGILQGRDY 108 Query: 133 ------KAHRGVWNKLA-------AGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYF 179 +G +KL AGS E GKKLGI+G G IG+ + A +LGM VY Sbjct: 109 VATLGDMTDKGEMSKLLEAEKKRFAGS-ELAGKKLGIVGLGAIGSMVANAALALGMDVYG 167 Query: 180 YD----IEN--KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGS 233 +D +E +LP + +++ L LL+ D ++LHVP +TKNM+ + MKP + Sbjct: 168 FDPALSVEAAWRLP-SDVHRMESLQALLSEIDYLTLHVPAIDATKNMINRDTLGFMKPSA 226 Query: 234 LLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHI 293 ++N +R +VD A+ +AL + L D FP EP L + V+ PHI Sbjct: 227 AIMNFARDAIVDSEAVVEALDAGKLRNYVCD-FP-EPC---------LIGHEKVIAVPHI 275 Query: 294 GGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSL-PLHGGRRLMHIHENRPGVLT 352 G ST EA+EN + +L Y +NG+ ++VNFPE S+ L G R+ ++N GVL Sbjct: 276 GASTAEAEENCAVMAVNQLRDYLENGNIKNSVNFPETSMGGLVSGCRITFTNQNVSGVLG 335 Query: 353 ALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 + +FAE VN+ ++ + Y ++DI D ++ L A+K++ I R++ Sbjct: 336 NVLSVFAENNVNVIDMMNKSRNDVAYNILDI--DTCPSDAVLAALKSVEHVISLRVI 390 >UniRef50_Q7UQL2 Phosphoglycerate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UQL2_RHOBA Length = 540 Score = 160 bits (404), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 99/319 (31%), Positives = 166/319 (52%), Gaps = 11/319 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFH-KGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + L+++ + Q+ ++ L A+ IE+ + L E+L++S+ + LRS +T + + Sbjct: 3 RILVLDDIAQEGIDLLEAS--EGIEYEVRTKLKGEELRQSLNEFDAAILRSGVTITPESL 60 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +L A+ +GT+ +D AA +RGI V N P NT S AE LL + R + A Sbjct: 61 EGNTRLRALVRAGVGTDNIDKPAATRRGIVVMNTPAGNTVSTAEHTFAMLLAMSRNIAAA 120 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD---IENKLP 187 N G W++ + GK LGI+G G IG ++ A++ M V +D +++ Sbjct: 121 NQSLVEGRWDRKKFMGTQVAGKTLGIVGMGRIGREVASRAQAFDMDVVAFDPFLTDDQAE 180 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 +V + D+L D +++H P P T+ ++G +++ +KPG +IN +RG + D Sbjct: 181 SLKVRRVATVDDMLPQIDYLTVHTPLTPETRGLIGMEQLEKVKPGLRIINVARGGIYDSE 240 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 A+ + L S L G A+DV+ EP T+S F P V+ TPH+G ST+EAQ + +E Sbjct: 241 AMVEGLKSGKLGGVALDVYENEPCTDSPLFGMP-----GVVCTPHLGASTEEAQTQVAVE 295 Query: 308 VAGKLIKYSDNGSTLSAVN 326 L+ Y G +VN Sbjct: 296 GIHLLLNYLRTGEIRHSVN 314 >UniRef50_B6H0R3 Pc12g10550 protein n=23 Tax=Fungi/Metazoa group RepID=B6H0R3_PENCW Length = 596 Score = 160 bits (404), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 110/326 (33%), Positives = 170/326 (52%), Gaps = 7/326 (2%) Query: 6 LEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 L + K L+ E + L LR++ ++ KG L ++L + I D + +RS T + Sbjct: 4 LRASRPKVLVPEKLSPDGLALLRSS--LDVHERKG-LSADELLQIIPDYDALLVRSETKV 60 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 T V+ AA+ L + +G + VD++ A K GI V N+P N + AE I ++ + R Sbjct: 61 TATVLRAAKNLKVVARAGVGVDNVDVEEATKLGIVVVNSPSGNIGAAAEHTIALMMSMAR 120 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYF---YDI 182 +PE+ A G W + E +GK L IIG G +G + LA+ LGM V Y Sbjct: 121 KIPESCASLKDGKWERSKFVGVEVKGKTLSIIGLGKVGLTVARLAKGLGMNVNALDPYAS 180 Query: 183 ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 + V L +LL +D +++H P ST+ M+ E++ +KPG+ ++N +RG Sbjct: 181 PAVAASASVALVSSLPELLASADFLTIHTPLIASTRGMIAEAELAQLKPGARVLNVARGG 240 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 D AL AL S HL+GAAIDVF +EP D + L ++TPH+G ST EAQE Sbjct: 241 TFDEDALLAALESGHLSGAAIDVFTSEPPA-PDSSAARLIAHPRAVVTPHLGASTVEAQE 299 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVNFP 328 N+ ++V ++++ SAVN P Sbjct: 300 NVSVDVCEQVLEILQGSLPRSAVNAP 325 >UniRef50_Q5ZYW9 D-3-phosphoglycerate dehydrogenase n=3 Tax=Legionella pneumophila RepID=Q5ZYW9_LEGPH Length = 295 Score = 159 bits (403), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 107/282 (37%), Positives = 157/282 (55%), Gaps = 22/282 (7%) Query: 23 ALESLRAA--GYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIG 80 A++ +R+ G+T IE DEQL + ++DA I L +R L+ VIN+A +L I Sbjct: 12 AMQEIRSELPGHTIIECDSRQWSDEQLIDFVKDADIIALTNR-RLSAAVINSALRLQLIA 70 Query: 81 CFCIGTNQVDLDAAAKRGIPVFNAP-FSNTRSVAELVIGELLLLLRGVPEANAKAH-RGV 138 G + +D DA +KR IPV NA ++NT +V+ELV G ++ L R +P+ N + +G+ Sbjct: 71 VAFAGIDHIDRDAVSKRNIPVKNAAGYANT-AVSELVFGLMISLARHIPDNNQRIREQGI 129 Query: 139 WNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLS 198 N E + K LGI+GYG IG ++ LA++ M YD ++++ L Sbjct: 130 TNT----GIELKNKVLGIVGYGAIGAEVARLAKAFQMTTIIYDRKSQVTL---------D 176 Query: 199 DLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHL 258 DL + SD V+LHVP TK M+ + +S MK + LIN +RG +V L AL + Sbjct: 177 DLFSQSDFVTLHVPLTNETKGMVNLRLLSQMKKSAYLINCARGPIVVNSDLKKALEQDMI 236 Query: 259 AGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 AGAA+DVF EP P L E N++ TPHIG +T+EA Sbjct: 237 AGAALDVFDVEPPL---PANYSLWEVPNLIATPHIGFNTREA 275 >UniRef50_B7P3M8 D-3-phosphoglycerate dehydrogenase, putative (Fragment) n=2 Tax=Coelomata RepID=B7P3M8_IXOSC Length = 473 Score = 159 bits (403), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 98/305 (32%), Positives = 152/305 (49%), Gaps = 15/305 (4%) Query: 46 QLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAP 105 +L ++I + +RS T +T DVI A + L IG G + +D DAA ++GI V NAP Sbjct: 39 ELLQAIEGYDALIVRSATKVTSDVIKAGQALKVIGRAGTGVDNIDCDAATRQGILVINAP 98 Query: 106 FSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQ 165 NT S AEL ++ L R +P A G W++ E GK L I+G G IG + Sbjct: 99 GGNTLSAAELTCAMIVTLSREIPAATMSLKAGKWDRKTFMGNELYGKTLAIVGLGRIGKE 158 Query: 166 LGILAESLGMYVYFYD--IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGA 223 + + +S GM +D + ++ + L ++ ++D +++H P P TK+++G Sbjct: 159 VALRMQSFGMKTIGFDPIVPKEVSREFGVESMSLDEIWPLADYITVHTPLIPQTKDLIGK 218 Query: 224 KEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCE 283 + K G +IN +RG +V+ L AL S H GA +DVF EP N+ P Sbjct: 219 ASLQKCKKGVKIINVARGGIVNEDDLLAALESGHCGGAGLDVFLEEPPKNTQLIAHP--- 275 Query: 284 FDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHI 343 V+ TPH+G +T+EAQ + E+A + + S S VN P +S + Sbjct: 276 --KVVCTPHLGANTKEAQLRVAQEIAEQFVDLSQGKSVPGVVNAPSLS--------QTQV 325 Query: 344 HENRP 348 EN+P Sbjct: 326 PENKP 330 >UniRef50_C0C1A5 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM 15053 RepID=C0C1A5_9CLOT Length = 345 Score = 159 bits (403), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 101/297 (34%), Positives = 149/297 (50%), Gaps = 45/297 (15%) Query: 42 LDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPV 101 + +E+L E RDA I + S +T VI AE L I C VD+ AA +RGIPV Sbjct: 35 MPEEELAEKTRDADMI-ITSYDDITRKVIENAEHLKLIACTRATPVNVDMAAAKERGIPV 93 Query: 102 FNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRG---------------------VWN 140 P N+ S AE+ IG +L R +P A KA +G +W+ Sbjct: 94 LYTPGRNSDSTAEMTIGLMLSAARKIPMAY-KALKGGEYTGDPSSRKETKEGLKADVIWD 152 Query: 141 KLAAGSF------EARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQV 194 A + + +GK LGI+GYG IG ++G +A + GM + +D P V Sbjct: 153 MKADAPYMVFKGTQLKGKTLGILGYGSIGRRVGRIARAFGMQLLIFD-----PFVGEVDV 207 Query: 195 QHL--------SDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + + +L+ SD ++ H+ P T ++ + I+LMKP + INASRG ++D Sbjct: 208 EEIGIKKAHSVEELMKESDFITCHMKVTPETTGIISRERIALMKPTAYFINASRGAILDE 267 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 AL +AL K +AGAA DV+ +EP P+ + E DNV++TPHI G+T + N Sbjct: 268 EALIEALKEKRIAGAAFDVYESEPIARDHPY---ITELDNVVVTPHIAGATDDVLVN 321 >UniRef50_A8IH65 D-isomer specific 2-hydroxyacid dehydrogenase n=3 Tax=Proteobacteria RepID=A8IH65_AZOC5 Length = 325 Score = 159 bits (403), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 99/250 (39%), Positives = 138/250 (55%), Gaps = 6/250 (2%) Query: 57 IGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELV 116 I +R + DV+ A+ +L I GTN +D++AAA G+PV A +N SVAE Sbjct: 51 IVVRVVEKIDADVMRASPRLKLIAKHGAGTNDIDVEAAAALGLPVIAAVGANAHSVAEHA 110 Query: 117 IGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMY 176 + LL L + + +A G W K FE RG+ LG++G G IG + + LGM Sbjct: 111 LALLLALAKDIRTQDAFVRGGGWEKRVYKGFELRGRTLGLVGLGMIGRSFAAMVQPLGMT 170 Query: 177 VYFYD-IENKLPLG-NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSL 234 V+ YD G + +V L D+L DV+SLH P P T+ ++ A+ + LMKPGSL Sbjct: 171 VFGYDPFAAPEAFGPHVERVADLDDMLGRCDVISLHCPLTPQTEGLINARALGLMKPGSL 230 Query: 235 LINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIG 294 LIN +RG VVD AL AL + L GA +D F EP + T PL NV+L+PHIG Sbjct: 231 LINTARGEVVDEEALVAALKNGPLGGAGLDSFAHEPPSP----THPLWSLPNVILSPHIG 286 Query: 295 GSTQEAQENI 304 G T++A+ + Sbjct: 287 GVTEDARRQV 296 >UniRef50_D2RMS7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RMS7_ACIFE Length = 529 Score = 159 bits (403), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 103/323 (31%), Positives = 162/323 (50%), Gaps = 9/323 (2%) Query: 9 DKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 DK K ++VE + K +E L+A + K + E+L + + D I +RS T + E+ Sbjct: 2 DKKKVIVVERISDKGVEMLKAQPDLEVTV-KFDIPREELLKIVGDYDAIIVRSVTKVNEE 60 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 AA L +G G + +D++ A KRGI V N P +N S AE IG +L R Sbjct: 61 FYQAARNLKVVGRAGNGVDNIDIEGATKRGIIVVNTPEANVISAAEHTIGLMLASCRNTV 120 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD---IENK 185 +A VW++ E K LGIIG G IGT + ++ M V YD +++ Sbjct: 121 KAQKMIESRVWDRKNLKGVELYHKTLGIIGLGRIGTLVTKRMQAFEMKVIAYDPYIPDSR 180 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 + + L DLL +DV+++H P+ T NM+G +E+ K G L+N +RG + + Sbjct: 181 FKRLGVEKCETLDDLLAKADVITIHTPKTEETINMIGKEELKKCKKGVRLVNCARGGLYN 240 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 A+ DA+ +A +DV EP SPL + +LTPH+G T EAQ+ +G Sbjct: 241 EQAVADAIKEGQVASIGLDVLVDEPKP-----ISPLIGLEQCVLTPHLGADTVEAQDKVG 295 Query: 306 LEVAGKLIKYSDNGSTLSAVNFP 328 + +A +++ + +AVN P Sbjct: 296 ISIAQEVVNVLNGQMVPNAVNLP 318 >UniRef50_O33116 D-3-phosphoglycerate dehydrogenase n=22 Tax=Actinomycetales RepID=SERA_MYCLE Length = 528 Score = 159 bits (402), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 96/269 (35%), Positives = 149/269 (55%), Gaps = 7/269 (2%) Query: 43 DDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVF 102 D +L ++ +A + +RS T + +V+ AA KL + +G + VD+DAA RG+ V Sbjct: 33 DRTKLLAAVPEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVV 92 Query: 103 NAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHI 162 NAP SN S AE + LL R + EA+A +W + + E GK +G++G G I Sbjct: 93 NAPTSNIHSAAEHALALLLAASRQIAEADASLRAHIWKRSSFSGTEIFGKTVGVVGLGRI 152 Query: 163 GTQLGILAESLGMYVYFYD--IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNM 220 G + + G +V YD + ++ DLL +D +S+H+P+ P T + Sbjct: 153 GQLVAARIAAFGAHVIAYDPYVAPARAAQLGIELMSFDDLLARADFISVHLPKTPETAGL 212 Query: 221 MGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSP 280 + + ++ KPG +++NA+RG +VD AL DA+ S H+ A +DVF TEP T+ SP Sbjct: 213 IDKEALAKTKPGVIIVNAARGGLVDEVALADAVRSGHVRAAGLDVFATEPCTD-----SP 267 Query: 281 LCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 L E V++TPH+G ST EAQ+ G +VA Sbjct: 268 LFELSQVVVTPHLGASTAEAQDRAGTDVA 296 >UniRef50_B7CA05 Putative uncharacterized protein n=1 Tax=Eubacterium biforme DSM 3989 RepID=B7CA05_9FIRM Length = 382 Score = 159 bits (402), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 110/362 (30%), Positives = 174/362 (48%), Gaps = 31/362 (8%) Query: 44 DEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFN 103 D ++ E++ D I +RS +L + I L AI G N +D+D K+GI VFN Sbjct: 21 DYEVNENMEDEDAILVRS-ANLHD--IEYGNNLKAIARAGAGVNNIDIDTCTKKGIAVFN 77 Query: 104 APFSNTRSVAELVIGELLLLLRGV---------PEANAKAHRGV-WNKLAAGSFEARGKK 153 P +N+ +V E V +LL R + + N + V K E GK Sbjct: 78 TPGANSNAVKEFVFAGMLLASRDIYHGIEWIQTQKENENIAKDVEKQKKKYAGHELTGKS 137 Query: 154 LGIIGYGHIGTQLGILAESLGMYVYFYD----IENKLPLGN-ATQVQHLSDLLNMSDVVS 208 LG+IG G IG Q+ LA GM VY YD ++ L V ++ DL D ++ Sbjct: 138 LGVIGCGAIGIQVANLALRFGMKVYGYDPYMSVDAAWNLSRYVNHVTNIDDLYRQCDFIT 197 Query: 209 LHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPT 268 +HVP N TKN + MK G L+N +RG +VD AL +AL +A D FP+ Sbjct: 198 IHVPLNDGTKNFINKDSFDKMKDGVKLLNFARGGLVDEDALLEALDENKVASYVTD-FPS 256 Query: 269 EPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFP 328 + SD V+ PH+G ST+E++EN ++ A +L+ Y G+ ++VN P Sbjct: 257 QKVLQSDK----------VIAIPHLGASTEESEENCAVKAARELMDYLTYGNISNSVNLP 306 Query: 329 EVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADED 388 + ++ R+ IH+N+P +++ + I + NI ++ + Y +ID++ D Sbjct: 307 NAKMDMNSPFRITCIHDNKPKMISQITDILKD--ANIENLMNKSKKDIAYTIIDLDTKVD 364 Query: 389 VA 390 + Sbjct: 365 IT 366 >UniRef50_A5W066 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=2 Tax=Pseudomonas RepID=A5W066_PSEP1 Length = 324 Score = 159 bits (402), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 107/293 (36%), Positives = 159/293 (54%), Gaps = 11/293 (3%) Query: 19 VHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVA 78 +H+ L L G + + A+ E+++ + DA F LR H++ ++I A+ KL Sbjct: 10 IHETILSRLSDLGEVRLGYGPNAVAYEEIRNQV-DAVF--LRG-GHISAEMIAASPKLRI 65 Query: 79 IGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGV 138 + G + VD AAA G+ V N P +N RSV E V LL L R +P A+ + V Sbjct: 66 VARHGAGYDNVDYKAAADHGVWVTNTPGANQRSVIEHVFALLLSLCRKLPLASEQTRNRV 125 Query: 139 W--NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQH 196 W ++L+ E G+ LG++G+G+IG+ + +AE+ GM V F D P ++ V Sbjct: 126 WAEDRLSLTGIELEGRTLGLVGFGNIGSSVAPVAEAFGMKVIFTDPAID-PSSDSRWVD- 183 Query: 197 LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASK 256 LL+ +DVVSLHVP +T+N++G E + MK G++LIN SRG VVD AL DAL S Sbjct: 184 FDTLLSTADVVSLHVPLLETTRNLIGVPEFAKMKDGAMLINTSRGGVVDEQALVDALKSG 243 Query: 257 HLAGAAIDVFPTEPATNSDPF---TSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 LAGA DV E PF T + N+++T H+ G T E+ +G+ Sbjct: 244 KLAGAGADVLAAENIDMIKPFDHDTPDIANTPNLIVTAHVAGQTDESLLRVGM 296 >UniRef50_A7GQE1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Firmicutes RepID=A7GQE1_BACCN Length = 390 Score = 159 bits (402), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 114/371 (30%), Positives = 185/371 (49%), Gaps = 34/371 (9%) Query: 57 IGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELV 116 I LRS + E++ ++ L AI G N + +D ++GI VFN P +N +V EL+ Sbjct: 35 ILLRSYSLHQEEL---SKNLKAIARAGAGVNNIPIDRCTEKGIVVFNTPGANANAVKELI 91 Query: 117 IGELLL----LLRGVPEANAKAHRGVWNKLAAGS-----FEARGKKLGIIGYGHIGTQLG 167 + +L ++ GV + + + AG E GK+LG+IG G IG + Sbjct: 92 LASFILSSRNIINGVSWTKGLEGKEIPQLVEAGKKQFVGSEIAGKRLGVIGLGAIGALVA 151 Query: 168 ILAESLGMYVYFYD----IENKLPLGNATQVQH---LSDLLNMSDVVSLHVPENPSTKNM 220 A SLGM V YD +E L +T VQ L ++ D ++LH+P T+ + Sbjct: 152 NDALSLGMDVVGYDPYISVETAWRL--STHVQRAFSLDEIFATCDYITLHIPLTEQTRGI 209 Query: 221 MGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSP 280 +G + +MK G L N SRG +VD AL AL + + D FP E Sbjct: 210 IGEHAVRMMKKGVRLFNFSRGELVDETALEKALEEETINHYMTD-FPNEN---------- 258 Query: 281 LCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRL 340 + + NV+ TPH+G ST E++EN + A +L Y + G+ ++VN+P V LP G +R+ Sbjct: 259 VIKMKNVVATPHLGASTYESEENCAVMAACQLRDYLETGNIRNSVNYPNVELPYVGKKRI 318 Query: 341 MHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIE--ADEDVAEKALQAMK 398 +H+N P ++ + AE +NIA ++ Y +IDI+ D+ + E ++ ++ Sbjct: 319 TIMHQNVPNMVGQITGCLAEHHINIADMINRSKNSWAYTMIDIDNGMDDRMKENIVENIR 378 Query: 399 AIPGTIRARLL 409 I G + R++ Sbjct: 379 RITGVVAVRMI 389 >UniRef50_C5RAQ7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Weissella paramesenteroides ATCC 33313 RepID=C5RAQ7_WEIPA Length = 329 Score = 159 bits (402), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 95/271 (35%), Positives = 150/271 (55%), Gaps = 19/271 (7%) Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 ++ D+ L + +G + +D+D AAK+G+ V N P +N SVAE+ + +L L Sbjct: 69 ISNDIYRQMPNLKILARRGVGYDNIDVDFAAKQGVWVTNTPGANAHSVAEMALMNMLQLR 128 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKL-----GIIGYGHIGTQLGILAESLGMYVYF 179 R + W AG+++ G+ L GI+GYGH+G +L L +LG+ V Sbjct: 129 RQFRLVDKLTRDDQW----AGAYQLLGQDLTAATIGIVGYGHVGQELARLLTALGVKVII 184 Query: 180 YDIENKL-PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINA 238 YD + K P G Q + +D++SLH+ P T++++G +E MKP S +IN Sbjct: 185 YDRKQKSSPYGKFVSWQKM---FETADIISLHLAAVPETRHIVGDREFQWMKPESAMINL 241 Query: 239 SRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQ 298 +RG ++D +L AL +K +AGAA+DVF EP T+PL + DNV++TPHIG +TQ Sbjct: 242 ARGQIIDEQSLIWALQNKQIAGAALDVFQQEPIDK----TNPLLKMDNVIVTPHIGANTQ 297 Query: 299 EAQENIGLEVAGKLIKYSDNGSTLS-AVNFP 328 +A + + + +A K+I G+ AVN P Sbjct: 298 QANQKMAM-IAAKMIDTVLRGAAPKYAVNNP 327 >UniRef50_D1C3Y3 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C3Y3_SPHTD Length = 316 Score = 158 bits (400), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 97/293 (33%), Positives = 156/293 (53%), Gaps = 10/293 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ + + AL+ LR ++ + +L ++L + + + +R T +T +VI Sbjct: 8 RILVCDPIDDGALDLLRRHARVDV---RTSLAPDELVDIVGGYDGLVVRGTTQITSEVIE 64 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AA L I + +D+DAA +RGI V ++P + T +VAE+ IG +L +LR +P A+ Sbjct: 65 AATALRGIARVGFAVDNIDIDAATERGIVVVHSPGARTYAVAEMTIGLILAVLRHIPAAD 124 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 G W + A + RG +G+IGYG IG ++ LA + G V Y + PL +A Sbjct: 125 RSVKAGRWERRAFRGRQLRGATVGVIGYGRIGREVARLAHAFGATVKAY-TQTPRPLEHA 183 Query: 192 TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCD 251 QV LL SD+++LH +T+ ++ + I M+ G +++N + G ++D AL + Sbjct: 184 KQVD-FQALLASSDIITLHATLTSATRQLINREAIEQMRDGVVIVNTASGGLIDEAALLE 242 Query: 252 ALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 AL +AGA +DVF EP P L E V+ TP IGGSTQEA + Sbjct: 243 ALDRGKVAGAGLDVFADEP-----PSLRALVEHPRVVTTPRIGGSTQEADRAV 290 >UniRef50_B5YAK7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Dictyoglomus thermophilum H-6-12 RepID=B5YAK7_DICT6 Length = 316 Score = 157 bits (396), Expect = 8e-37, Method: Compositional matrix adjust. Identities = 96/269 (35%), Positives = 147/269 (54%), Gaps = 14/269 (5%) Query: 41 ALDDEQLKESIRDAH--FIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRG 98 L +E+++E IRD +G+ +T V+ A KL I + +G + +D+ A KR Sbjct: 37 VLTEEEMRELIRDVDGLIVGI---DPVTSKVLKNANKLKVISKYGVGVDNIDILEAKKRN 93 Query: 99 IPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIG 158 I V N P +N+ +VAEL +G ++ +LR + ++ K G W++ E K LG+IG Sbjct: 94 IVVTNTPGANSNAVAELTVGLIINVLRKINLSDKKTREGRWDRFIGN--ELSEKTLGVIG 151 Query: 159 YGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQH--LSDLLNMSDVVSLHVPENPS 216 G IG ++ L + + V +D + +V + L +LL SDVVS+HVP Sbjct: 152 TGSIGRRVIELLKGFNLRVLCFDKYPDYEWASKEKVFYVTLDELLRSSDVVSIHVPLTEE 211 Query: 217 TKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDP 276 T +M+ KE+ +MK ++LIN SRG +VD AL L ++GA +DVF EP P Sbjct: 212 TYHMISEKELRMMKKNAVLINTSRGGIVDEDALYRFLKEGRISGAGLDVFEKEP-----P 266 Query: 277 FTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 SPL + DNV++T HIG T+EA N+ Sbjct: 267 QNSPLLQLDNVVVTSHIGAHTEEAVANMA 295 >UniRef50_Q7WEA3 Phosphoglycerate dehydrogenase n=1 Tax=Bordetella bronchiseptica RepID=Q7WEA3_BORBR Length = 329 Score = 157 bits (396), Expect = 9e-37, Method: Compositional matrix adjust. Identities = 112/307 (36%), Positives = 161/307 (52%), Gaps = 17/307 (5%) Query: 14 LLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAA 73 ++ + VH + LRAAG T IE LD L++ I A + +R + L ++I+ A Sbjct: 5 VIAQPVHPVGPQLLRAAGITVIEPAGPGLD--ALRQVIAGADAVLVRDQ--LPAELIDMA 60 Query: 74 EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAK 133 +L I GT+++ + A GIPV P +N RSVAE + +L+ R +A+A Sbjct: 61 PRLCVIANHGTGTDKIAVAHADALGIPVVYTPQANVRSVAEHALMLMLVTARQAVQADAA 120 Query: 134 AHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLG-ILAESLGMYVYFYDIENKLPLGNA 191 +G W K + GK LG+IG G G L + A +L M + LP G A Sbjct: 121 TRKGHWGFKYEQPMYSLYGKTLGVIGLGRTGRLLCEMAAPALNMQALVWS--PSLPAGEA 178 Query: 192 -----TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 +V L +LL +DVVSLH P P T++ + A ++ MKPG+++IN SRG ++D Sbjct: 179 LPPGARRVDTLQELLREADVVSLHRPLRPDTRHTLDAATLACMKPGAIVINTSRGGLIDE 238 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL DAL LAGA +DVF TEP P S + N +LTPH+ GSTQEA Sbjct: 239 AALADALREGRLAGAGLDVFETEPL----PAGSRVAGLPNAVLTPHVAGSTQEALHATAS 294 Query: 307 EVAGKLI 313 + A ++I Sbjct: 295 QCAEQII 301 >UniRef50_B5JEX5 D-3-phosphoglycerate dehydrogenase n=2 Tax=Verrucomicrobiales RepID=B5JEX5_9BACT Length = 545 Score = 156 bits (395), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 105/324 (32%), Positives = 164/324 (50%), Gaps = 11/324 (3%) Query: 11 IKFLLVEGVHQKALESLRAA-GYTNIEFHKGALDD-EQLKESIRDAHFIGLRSRTHLTED 68 +K L+ + + ++ L+ G+ +E + +D + E + A I +RS + +T + Sbjct: 14 MKILVADKISSTGVDFLKQQEGFEVVEAYGTFKEDYSKFLELAKGAAAIIVRSDSKVTRE 73 Query: 69 VIN-AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 V AA L A+G +G + +D +AA G+ V N P NT + AEL +L R V Sbjct: 74 VFEVAAPTLKAVGRAGVGVDNIDSEAATDFGVVVMNTPGGNTIATAELTFTHMLCGARPV 133 Query: 128 PEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD---IEN 184 P+A G W++ G E K LG+ G G IG ++ A++ GM V YD Sbjct: 134 PQAAQSMREGRWDRKIYGGSELFKKTLGVCGMGRIGAEVAKRAKAFGMKVLAYDPYLSGA 193 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 K QV+ L +L SD +++H+P +T+ M+ I+ MK G L N +RG ++ Sbjct: 194 KAETMGVEQVE-LDELFRESDYITVHMPLTDATRGMIDDAAIATMKDGVRLFNCARGGII 252 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL L S +A A +DV+ +EP PF S + LTPH+G ST+EAQE++ Sbjct: 253 DEDALLRGLESGKVAAAGLDVYTSEPPAEDHPFRSQ----KTLNLTPHLGASTEEAQESV 308 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFP 328 GLE+A + G +A+N P Sbjct: 309 GLEIAESVTSVLRGGGIRNAINMP 332 >UniRef50_C1SGT4 D-3-phosphoglycerate dehydrogenase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SGT4_9BACT Length = 544 Score = 156 bits (395), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 98/322 (30%), Positives = 165/322 (51%), Gaps = 9/322 (2%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K K L+ + + Q + L++ ++ G + + LK+ I + I RS T +T ++ Sbjct: 3 KYKVLITDHISQDGVNILKSDKDIEVDIQAG-IKNPDLKKIIGNYDAIITRSGTTVTAEL 61 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I KL IG +G + VD++AA+ +GI V NAP NT + EL +G +L ++R +P Sbjct: 62 IENPGKLKIIGRAGVGLDNVDIEAASMKGIIVMNAPTGNTLAACELTMGMMLSVVRKLPL 121 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 AN G W++ + K L ++G G IG + ++ M V YD K Sbjct: 122 ANQVTKSGEWDRKRFMGIQLYQKTLAVVGLGRIGGNVAKRCKAFDMKVVAYDPYIKKSRA 181 Query: 190 NATQVQ---HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + V+ L + ++ +D+++ H P TKN++ EI+ MK G ++IN +RG +V+ Sbjct: 182 ESLGVELCNSLEEAISQADIITFHTPLTDETKNLITKDEIAKMKDGVVIINCARGGIVNE 241 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 L DA S + A +DVF +EP P P + +N+ +TPHIG +T E Q + + Sbjct: 242 LDLVDACKSGKVTAAGLDVFMSEP-----PVNHPFFDVENIYVTPHIGANTAEGQYGVAV 296 Query: 307 EVAGKLIKYSDNGSTLSAVNFP 328 +A +++ S +AVN P Sbjct: 297 IIAEQVVNALHGRSYKNAVNIP 318 >UniRef50_C1A4S7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1A4S7_GEMAT Length = 534 Score = 156 bits (395), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 94/270 (34%), Positives = 147/270 (54%), Gaps = 7/270 (2%) Query: 42 LDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPV 101 L ++L I + I RS T ++ +++ A KL +G +G + ++LD A GI + Sbjct: 32 LPKDELLRRIGEYDAIVGRSATRISAELLKAGGKLKVVGRAGVGVDNIELDVATSLGIAI 91 Query: 102 FNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGH 161 NAP NT +VAEL G ++ LLR + A A G W++ E +GK LGI+G G Sbjct: 92 INAPAGNTVAVAELFFGTVIGLLRQLHTAAAAMGDGRWDRAKFMGRELKGKTLGIVGLGR 151 Query: 162 IGTQLGILAESLGMYVYFYD---IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTK 218 IG+++ A + GM V YD + + + L LL ++V++LHVP T+ Sbjct: 152 IGSEVAARAHAFGMTVVAYDPYIADERFAALRVRRAPSLDALLAETNVLTLHVPLTDETR 211 Query: 219 NMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFT 278 M+G +E++ + S+++N +RG V++ AL AL + L GA +DVF EP Sbjct: 212 GMIGKRELARLPARSVVVNLARGGVIEEAALQAALETDQLRGAVLDVFTVEPLAPD---- 267 Query: 279 SPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 SPL N++LTPH+G +T EAQ N+ +V Sbjct: 268 SPLRNIPNLVLTPHLGANTVEAQRNVSRDV 297 >UniRef50_C6PIV3 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Thermoanaerobacter italicus Ab9 RepID=C6PIV3_9THEO Length = 325 Score = 156 bits (395), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 106/308 (34%), Positives = 157/308 (50%), Gaps = 10/308 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K LL E +H + L G I + +E L +RD I +RS+ +T+ +I Sbjct: 3 KVLLSEEIHPDGRKILEEKGIEIIT--APDVKEETLISMVRDVEAIIVRSKAKITKGIIE 60 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A KL I G + +D++AA ++GI V N P N+ SVAE I +L L + + + Sbjct: 61 NAPKLKIISRTGAGVDNIDVNAATEKGILVCNLPAVNSLSVAEHTIAMILHLAKQLSLMD 120 Query: 132 AKAHRGVWNKLAAG-SFEARGKKLGIIGYGHIGTQLGILA-ESLGMYVYFYD--IENKLP 187 G W + S E GK LGI+G G+IG + + LGM + YD ++ K Sbjct: 121 QAVRNGNWEMRNSNISVEVEGKTLGIVGMGNIGILVAKKCHDGLGMKIVAYDPYVKEKFK 180 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + V L +L SD V+LH P+ P T+ M+ + I MKP + LIN +RGTV+D Sbjct: 181 DYDYRFVDSLEELFKESDFVTLHCPDIPETRGMITRELIYSMKPTAYLINVARGTVIDEQ 240 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL +AL K +AGA +DVF EP + + L +NV+L+PH T+EA + +E Sbjct: 241 ALIEALKEKRIAGAGLDVFQQEPPSRDN----ELLRLENVILSPHSAALTKEATVRMAVE 296 Query: 308 VAGKLIKY 315 +I Y Sbjct: 297 AVQAVIDY 304 >UniRef50_A9CLC8 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=4 Tax=Alphaproteobacteria RepID=A9CLC8_AGRT5 Length = 349 Score = 156 bits (394), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 85/247 (34%), Positives = 133/247 (53%), Gaps = 7/247 (2%) Query: 64 HLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLL 123 +E I AA L + +G + +D+DAA++R IPV A +N SVAE I L + Sbjct: 77 RFSEAAIKAAPSLRVLSKHGVGVDNIDVDAASRREIPVVVAAGANALSVAEHAITLLFAV 136 Query: 124 LRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI- 182 ++ + ++ G W K E G +G++G+G I Q + A G+ V YD Sbjct: 137 VKRIVPLDSGIRAGRWEKAGYSGKELAGMIIGLVGFGAIARQTAVFARGFGLKVQAYDPF 196 Query: 183 --ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 E +V + DL++ SD++SLH P P T+N++ + + +MKPGS +IN +R Sbjct: 197 TDETAFVEAGVHRVADVDDLISSSDILSLHCPLTPDTRNLLDDRRLGMMKPGSFIINTAR 256 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G ++D AL A+ S H+AGA +D F EP + PF + +++TPHIGG TQEA Sbjct: 257 GGLIDEDALLRAVESGHIAGAGLDTFQIEPPAANHPF----WQNQKIVVTPHIGGVTQEA 312 Query: 301 QENIGLE 307 +G++ Sbjct: 313 NVRVGVD 319 >UniRef50_A1RYE4 Glyoxylate reductase n=18 Tax=cellular organisms RepID=GYAR_THEPD Length = 339 Score = 156 bits (394), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 96/276 (34%), Positives = 143/276 (51%), Gaps = 11/276 (3%) Query: 45 EQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNA 104 E+L +IRD + + +V++AA L I + +G + +D+ A KRGI V + Sbjct: 39 EELLRNIRDKDALLCLLTDKIDAEVMDAAPNLKVISTYSVGFDHIDIPEATKRGIYVTHT 98 Query: 105 PFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSF----EARGKKLGIIGYG 160 P T +VAE +G +L + R + EA+ G W+K F E +GK +G++G G Sbjct: 99 PGVLTDAVAEFTVGLILAVTRRIVEADKIIRTGQWDKPWNPYFLTGPELKGKTIGLVGLG 158 Query: 161 HIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDL---LNMSDVVSLHVPENPST 217 IG S + + +YDIE + + +DL L SD+VS+HVP T Sbjct: 159 RIGVATAKRLSSFDVKILYYDIERRWDVETVIPNMEFTDLDTLLEKSDIVSIHVPLTKET 218 Query: 218 KNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPF 277 +++ + + MK + LIN +RG VVD AL AL +AGAA+DVF EP P Sbjct: 219 YHLINEERLRKMKKTAYLINTARGPVVDTEALVKALKEGWIAGAALDVFEQEPL----PP 274 Query: 278 TSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLI 313 PL +FDNV+L PHI +T EA++ + A LI Sbjct: 275 NHPLTKFDNVVLAPHIASATIEARQRMAELAARNLI 310 >UniRef50_B3RTC6 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RTC6_TRIAD Length = 520 Score = 155 bits (393), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 106/322 (32%), Positives = 159/322 (49%), Gaps = 13/322 (4%) Query: 9 DKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 D K L+ + V K L A G K L +L I + + +RS T +T + Sbjct: 3 DIRKVLISDSVDPKCKSVLEAKGIEVTLNTK--LSPAELVAEIPNYDGLIVRSATKVTAE 60 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 VI A + L IG G + +D+ AA + G+ V N P NT S AE ++ L R VP Sbjct: 61 VIKAGKNLKIIGRAGTGVDNIDIKAATECGVIVMNTPGGNTLSAAEHTCTLMVCLARQVP 120 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL 188 +A A G W++ E GK LGIIG G IG ++ +S G+ YD +P Sbjct: 121 QAAASMREGRWDRKKYMGIELMGKTLGIIGLGRIGREVATRMQSFGVRTVGYD--PIVPA 178 Query: 189 GNATQVQ----HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 A + L+DL D +++H P P T+ ++G + + K G +IN +RG ++ Sbjct: 179 EAAKEFDVEFFELNDLWPECDFITVHTPLIPQTRGLLGDETFAKCKKGVRVINCARGGII 238 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL AL S AGAA+DVF EP N++ L + NV+ H+G ST EAQ + Sbjct: 239 DEAALLRALQSGQCAGAALDVFEQEPPQNTE-----LVQHPNVIPVCHLGASTVEAQSRV 293 Query: 305 GLEVAGKLIKYSDNGSTLSAVN 326 +E+A + + +++ S A+N Sbjct: 294 AVEIAEQFVDFNEGKSLFGAIN 315 >UniRef50_B6G9P0 Putative uncharacterized protein n=3 Tax=Bacteria RepID=B6G9P0_9ACTN Length = 427 Score = 155 bits (392), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 112/383 (29%), Positives = 187/383 (48%), Gaps = 38/383 (9%) Query: 46 QLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAP 105 + E DA I +RS D+ E + AIG G N + ++ A+RG+ VFN+P Sbjct: 63 EFVERAEDADAILMRSTDLHGYDL---PEGIRAIGRCGAGVNNIPIEEYARRGVVVFNSP 119 Query: 106 FSNTRSVAELVIGELLLLLRGV-------------PEANAKAHRGVWNKLAAGSFEARGK 152 +N+ +V E+V+ +++ RG+ P+ A + K A E RGK Sbjct: 120 GANSNAVKEIVLAMMIMSSRGIVQAMQWVRANADDPDILTSAEKA---KKAFVGREIRGK 176 Query: 153 KLGIIGYGHIGTQLGILAESLGMYVYFYD----IENKLPLGNATQ-VQHLSDLLNMSDVV 207 ++G++G G++G+++ LGM VY YD +E+ L Q V L DL D + Sbjct: 177 RIGVVGLGNVGSKVANACVELGMDVYGYDPFISVEHAWALNREVQRVGTLEDLCRGCDYL 236 Query: 208 SLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFP 267 +LHVP T M+ ++++L+ PG++LIN +R T++D A+ AL + L+ A D F Sbjct: 237 TLHVPSKADTVGMISTEQLALLAPGAVLINFARETIIDEDAVAAALEAGKLSWFACD-FA 295 Query: 268 TEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNF 327 T P T P T +T H G T+EA+ N +L Y +NG+ +VN+ Sbjct: 296 T-PKTVRMPRT---------FITTHSGAGTEEAEANCADMAISELKDYLENGNIAHSVNY 345 Query: 328 PEVSL-PLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEAD 386 P S+ R+ +H N P ++ + I A+ N+ +++ + Y + D D Sbjct: 346 PACSMGKARAASRIACLHANVPNMIGQITAILAKDNANVQRMVNESAGENAYTMFD--TD 403 Query: 387 EDVAEKALQAMKAIPGTIRARLL 409 E + ++A+K IP R R++ Sbjct: 404 EHLDRATIEALKQIPSMYRVRVI 426 >UniRef50_C4TXE2 D-3-phosphoglycerate dehydrogenase n=3 Tax=Bacteria RepID=C4TXE2_YERKR Length = 317 Score = 155 bits (392), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 103/285 (36%), Positives = 146/285 (51%), Gaps = 34/285 (11%) Query: 42 LDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPV 101 L ++QL +DA F+ + S +T VI A +L I C +D+ AA +RGIPV Sbjct: 13 LSEDQLIALGQDADFL-VTSYDDITARVIKACPQLKLIACTRASPVNIDVKAATERGIPV 71 Query: 102 FNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRG----------------VWNKLAAG 145 P N+ + AEL I +L + R +P+A++ +G VW+ Sbjct: 72 IYTPGRNSDAAAELTIALMLNVARHIPQAHSALKQGQFTATEQSHFGLKTDVVWDVTKDS 131 Query: 146 SFEA------RGKKLGIIGYGHIGTQLGILAESLGMYV-----YFYDIENKLPLGNATQV 194 +E R K LGI+GYG IG ++G +A + GM + Y ++E P Sbjct: 132 PYEVFKGIELRNKTLGIVGYGSIGQRVGRIARAFGMQLLVADPYVSEVELDEP---GIHK 188 Query: 195 QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALA 254 L L + +D VSLH+ P T+ ++ A SLMKP + IN SR VV L DAL Sbjct: 189 STLEQLFSQADFVSLHLKVTPQTEGLIDAHLFSLMKPEAYFINTSRAAVVVEQHLIDALR 248 Query: 255 SKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQE 299 K LAGAA+DV+ EP S PF + EFDNV++TPHI G+T+E Sbjct: 249 HKQLAGAALDVYAHEPIHASHPF---IHEFDNVVITPHIAGATRE 290 >UniRef50_C0WBM0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acidaminococcus sp. D21 RepID=C0WBM0_9FIRM Length = 529 Score = 155 bits (391), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 108/328 (32%), Positives = 164/328 (50%), Gaps = 13/328 (3%) Query: 9 DKIKFLLVEGVHQKALESLRA--AGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLT 66 +K K L+ E + K + L+A A ++F + E L + I + + +RS T + Sbjct: 2 EKQKVLVAERISDKGVVCLKAEKALDVTVDFD---IKREDLLQVIGNYDALIVRSVTKVN 58 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 E++ +AA+KL IG G + +DLD A KRGI V N P +N S AE IG LL R Sbjct: 59 EELYDAAKKLKVIGRAGNGVDNIDLDGATKRGIIVVNTPEANIISAAEHTIGLLLASCRN 118 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD---IE 183 AN G+W + E K LGIIG G IG + + M V YD + Sbjct: 119 TVRANKMLEEGIWERKDLKGSELYHKTLGIIGLGRIGALVTKRMHAFDMRVIAYDPYIPD 178 Query: 184 NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 ++ + + L DLL +DV+++H P+ T NM+GA E K G ++N +RG + Sbjct: 179 SRFQRLGVEKCETLDDLLKEADVITIHTPKTEETVNMLGAAEWKKCKKGVRVVNCARGGL 238 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 + L +A+ +A +DV EP +P SPL ++TPH+G ST EAQ+ Sbjct: 239 YNEQDLAEAVKEGIVASVGLDVVVDEP----NPI-SPLIGMPQCVVTPHLGASTFEAQDK 293 Query: 304 IGLEVAGKLIKYSDNGSTLSAVNFPEVS 331 +GL +A ++I +AVN P ++ Sbjct: 294 VGLAIAEEVINVLGGKMVPNAVNLPAIA 321 >UniRef50_D1FX73 3-phosphoglycerate dehydrogenase-like protein n=1 Tax=Chironex fleckeri RepID=D1FX73_CHIFL Length = 520 Score = 155 bits (391), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 96/323 (29%), Positives = 159/323 (49%), Gaps = 6/323 (1%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 IK +L+ + +++ + N+++ G + E+L I+D + +RS T +T +V Sbjct: 6 IKRVLISDKVDEVCKTIFESNKINVDYRPG-ISKEELLAIIKDYDCLVVRSATKVTAEVF 64 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +AA L +G G + +DL AA G+ V N P NT S AE + L R +P+ Sbjct: 65 SAAPNLKLVGRAGTGVDNIDLKAATNNGVFVMNTPGGNTMSAAEHTCAMMFSLARHIPQG 124 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IENKLPL 188 G W + E +GK LGIIG G IG ++ + ++ M YD + + Sbjct: 125 YMSMQEGKWERSKFMGCELKGKTLGIIGLGRIGKEVALRMQACEMRTVGYDPIVPKEAAA 184 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + L ++ + D +++H P P TK ++ AK K +IN +RG ++D Sbjct: 185 EFGVEFMELEEMWPIVDFITVHTPLIPQTKGLVNAKTFDKCKKTIRVINVARGGIIDESD 244 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L DAL + AGA +DVF +EP + S L + V+ TPH+G ST EAQ + E+ Sbjct: 245 LLDALNAGKCAGAGLDVFSSEPPSG---VVSELVKHPRVVCTPHLGASTAEAQVRVAKEI 301 Query: 309 AGKLIKYSDNGSTLSAVNFPEVS 331 A +++ + + + VN P +S Sbjct: 302 AEQIVDACNGKTAVGLVNAPAIS 324 >UniRef50_UPI0000DB72A4 PREDICTED: similar to 3-phosphoglycerate dehydrogenase n=2 Tax=Apocrita RepID=UPI0000DB72A4 Length = 478 Score = 154 bits (390), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 94/277 (33%), Positives = 145/277 (52%), Gaps = 4/277 (1%) Query: 39 KGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRG 98 K L E+L + +++ + +RS T +T DV L +G G + +DL+AA ++G Sbjct: 32 KYKLSKEKLIKELQNHEGLIVRSETKVTADVFACCPNLRVVGRAGTGVDNIDLEAATRKG 91 Query: 99 IPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIG 158 + V N P N+ S EL + L R V +A G W++ FE GK L ++G Sbjct: 92 VIVLNTPGGNSISACELTCALISNLARNVTQAVQSLKDGRWDRKLYSGFELSGKTLAVLG 151 Query: 159 YGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLS--DLLNMSDVVSLHVPENPS 216 G IG ++ ++ GM V +D N V+ S ++ M+D +++H P P Sbjct: 152 MGRIGREVTRRMQAYGMRVIAFDPLLTSEDANYLNVEKFSLDEIWPMADYITVHTPLIPQ 211 Query: 217 TKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDP 276 TKN++ A ++ K G +IN +RG +VD AL +AL S H AGAA+DVF EP NS Sbjct: 212 TKNLINATTLAKCKKGVRIINVARGGIVDEEALLNALKSGHCAGAALDVFTEEPPKNS-- 269 Query: 277 FTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLI 313 L V+ TPH+G ST+EAQ+ + E+A + + Sbjct: 270 VILELIAHPKVISTPHLGASTEEAQQRVAEEIAQQFL 306 >UniRef50_D1CGN8 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CGN8_THET1 Length = 319 Score = 154 bits (390), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 97/244 (39%), Positives = 132/244 (54%), Gaps = 11/244 (4%) Query: 64 HLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLL 123 LT VI AA +L I +G + +DL+AA +RGI V P + SVA+L +G ++ + Sbjct: 64 ELTARVIEAAGRLRTIAKHGVGLDNIDLEAARRRGIVVTATPGAIHDSVADLTMGLIIAV 123 Query: 124 LRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI- 182 R + A+ G W E R K LGIIG G IG + + A GM V YD+ Sbjct: 124 ARQIVPAHNSTVAGEWRNFVG--LELRDKTLGIIGLGRIGKGVCLRALPFGMRVVAYDLY 181 Query: 183 -ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 + + + + L +LL SDVV+LH + ++G +EI LMKPG++ IN SRG Sbjct: 182 PDEEFARAHGVRFVGLEELLATSDVVTLHASAGNDGR-LLGRREIGLMKPGAIFINTSRG 240 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 +VD ALC+ALA LAGA +DVF EP PL E NV+LTPHI G T+E Sbjct: 241 KLVDEGALCEALAVGRLAGAGLDVFEEEPPRG------PLLELPNVVLTPHIAGQTREGM 294 Query: 302 ENIG 305 +G Sbjct: 295 IRMG 298 >UniRef50_Q0B0Y6 D-3-phosphoglycerate dehydrogenase n=9 Tax=Bacteria RepID=Q0B0Y6_SYNWW Length = 530 Score = 154 bits (390), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 97/324 (29%), Positives = 168/324 (51%), Gaps = 13/324 (4%) Query: 9 DKIKFLLVEGVHQKALESLRAAGYTNIEF-HKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 ++ K ++ E + + +E L+ T +E ++ + E+L E I + +RS T + E Sbjct: 2 ERKKVIVSERIADEGIELLK----TELEVDYRDGISREELLEIIDQYDALIVRSVTQVDE 57 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 ++I A++L +G G + +D+D + G+ V N P SNT S AE I LL +R Sbjct: 58 ELIRRAKRLKIVGRAGNGIDNIDVDVCTRYGVIVANTPDSNTISAAEQTISLLLSSIRNT 117 Query: 128 PEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD---IEN 184 A+ G W++ E GK +GI+G G IG+ + ++ M V YD + Sbjct: 118 AWASEYLKGGTWDRKPFRGVELYGKTVGIVGLGRIGSMVATRLKAFNMRVIAYDPYISDE 177 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + A +++ L +L+ +D +++H P N T +M+ + + L K G ++N +RG ++ Sbjct: 178 RFTRFGAEKMESLEELVKEADFITVHTPRNEETMHMIDERILGLAKEGVRVVNCARGGII 237 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 AL L SK + A +DVF EPA + +PL +F +V++TPH+G T EAQ+ + Sbjct: 238 KEEALLKGLESKKVLSAGLDVFEKEPAID-----NPLFQFKSVVVTPHLGADTFEAQKRV 292 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFP 328 G +A ++IK + VN P Sbjct: 293 GENIAEQVIKALKGEIVPNLVNLP 316 >UniRef50_D1YY17 Glycerate dehydrogenase n=1 Tax=Methanocella paludicola SANAE RepID=D1YY17_METPS Length = 326 Score = 154 bits (390), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 106/280 (37%), Positives = 146/280 (52%), Gaps = 19/280 (6%) Query: 44 DEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFN 103 DE I+DA + + R + + I A L I + G + VDL AA RG+ V N Sbjct: 35 DEDFVSRIKDAEIV-IAGRYGFSGESIRRAPGLKMIALWQTGYDNVDLAAATARGVVVSN 93 Query: 104 APFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIG 163 +VAE L LLR V +A+ RG+++ E GK LG+IG G IG Sbjct: 94 VHNYAFDTVAEFAFALALNLLRKVDKADLNLRRGLFDWRRYVGEELMGKTLGVIGLGSIG 153 Query: 164 TQLGILAESLGMYVYFY----DIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKN 219 ++ +A M V D E LG + L LL SDVVSLHVP P T++ Sbjct: 154 RRVVQIAHGFNMSVLSVTAHPDPERARALG--VKFVSLDTLLAESDVVSLHVPLTPETEH 211 Query: 220 MMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTS 279 M+GA +++ MKP ++LIN +RG +VD AL +AL K +AGA +DVF TEP P S Sbjct: 212 MIGAAQLARMKPTAILINTARGKIVDEKALVEALREKRIAGAGLDVFETEPL----PMDS 267 Query: 280 PLCEFDNVLLTPHIGGSTQEA--------QENIGLEVAGK 311 PL + DNV+LTPHI ++E+ EN+ + V G+ Sbjct: 268 PLLKLDNVVLTPHIAFLSKESIDECTRVTMENVEMFVKGR 307 >UniRef50_B1R2D5 Glycerate dehydrogenase n=6 Tax=Clostridiales RepID=B1R2D5_CLOBU Length = 314 Score = 154 bits (389), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 104/283 (36%), Positives = 148/283 (52%), Gaps = 8/283 (2%) Query: 43 DDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVF 102 D E L E +DA + L S +DVI L I G + VD+D RGI V Sbjct: 39 DSETLIERSKDAEIVVL-SNFQYRKDVIEKCPNLKMICVAFTGVDHVDIDYCKDRGITVC 97 Query: 103 NAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHI 162 N +T +VA+LV G L+ + R + E N +G K FE GKK G+IG G I Sbjct: 98 NCAGYSTVAVADLVFGLLINIYRNIVECNIVTRKG-GTKNGLVGFELEGKKFGVIGTGAI 156 Query: 163 GTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMG 222 G ++ +A++ G VY Y + G + L+ LL+ DV+SLHVP N +TK ++ Sbjct: 157 GMRVANIAKAFGCEVYAY--SRTVKEGKEIKYVDLNTLLSTCDVISLHVPLNENTKGLIN 214 Query: 223 AKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLC 282 + I LMK ++LIN +RG VVD AL DAL + +AGA IDVF EP P L Sbjct: 215 EENIKLMKKSAVLINTARGPVVDSKALSDALKNNIIAGAGIDVFEIEPPI---PVDHVLF 271 Query: 283 EFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAV 325 + N+++TPH+ +T+E+ V + KY NGS+ + + Sbjct: 272 DAPNLIVTPHVAFATKESMVKRAEIVFDNIDKYI-NGSSQNVI 313 >UniRef50_A8LSC9 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=4 Tax=Proteobacteria RepID=A8LSC9_DINSH Length = 316 Score = 154 bits (389), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 96/251 (38%), Positives = 138/251 (54%), Gaps = 9/251 (3%) Query: 59 LRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIG 118 +R+RT + ++AA +L IG G + +D+ A A RGI V A +NTRSVAE VI Sbjct: 50 VRNRTQVDRPFLDAASRLRVIGLLGTGLDNIDMAACAARGISVHPATGANTRSVAEYVIT 109 Query: 119 ELLLLLRGVPEANAKAHRGVWNKLAAGSF-EARGKKLGIIGYGHIGTQLGILAESLGMYV 177 L+L R + + G W + G E G+KLG+ G G + + LA+ L M + Sbjct: 110 AALMLTRRAFMSTPEMQEGAWPRGPLGEGGEIAGRKLGLYGCGAVAQAVARLAKPLSMTI 169 Query: 178 YFYD--IENKLPLGNATQVQHLSD--LLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGS 233 +D + PL T+V +SD LL +DV+SLH+P P T+ + A ++ MKPG+ Sbjct: 170 LGHDPHLGPGHPLW--TEVTRVSDAELLARADVLSLHLPLTPETRGRIDATALTAMKPGA 227 Query: 234 LLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHI 293 +LIN + G +VD A+CDAL HL GAA+DVF EP D + N++LTPH+ Sbjct: 228 ILINTAHGEIVDARAVCDALRRGHLGGAALDVFEPEPLGTQD--AARFRGVPNLILTPHV 285 Query: 294 GGSTQEAQENI 304 G T EA + Sbjct: 286 AGVTVEADRRV 296 >UniRef50_B8KU15 D-3-phosphoglycerate dehydrogenase n=1 Tax=gamma proteobacterium NOR51-B RepID=B8KU15_9GAMM Length = 317 Score = 154 bits (388), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 100/270 (37%), Positives = 149/270 (55%), Gaps = 19/270 (7%) Query: 43 DDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVF 102 +D+Q+ E IR + + + L+ +V++AA +L IG GT+ +DLDAA + GI V Sbjct: 34 EDDQVVERIRGSQLV-FTNAIELSAEVLSAAPELAFIGLTATGTDNIDLDAAGEAGIVVS 92 Query: 103 NAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVW------NKLAAGSFEARGKKLGI 156 N T+SV E VIG LL+L + ++ RG W N L E G LGI Sbjct: 93 NLRAYCTQSVVEHVIGTLLMLSHNLNHYSSHVRRGGWQQSQDGNDLVWPIREVSGLTLGI 152 Query: 157 IGYGHIGTQLGILAESLGMYVYFYDIENK--LPLGNATQVQHLSDLLNMSDVVSLHVPEN 214 IG+G +G + A LGM V +P G + L+++ DV+SLH P + Sbjct: 153 IGFGELGRGVAKAATGLGMDVVVAARPGSPTVPEGR----ESLAEIYRRCDVISLHCPLD 208 Query: 215 PSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNS 274 +T+ ++ A + MK +LLIN +RG ++D AL AL+SK +AGAAIDV P EP + Sbjct: 209 DNTRGLINADALDAMKDNALLINTARGALIDTAALATALSSKTIAGAAIDVLPQEPPVDG 268 Query: 275 DPFTSPLCEF--DNVLLTPHIGGSTQEAQE 302 D PL ++ DN++LTPHI ++EA++ Sbjct: 269 D----PLLDYTGDNLILTPHIAWGSREARQ 294 >UniRef50_C6VJE2 Phosphoglycerate dehydrogenase n=12 Tax=Lactobacillus RepID=C6VJE2_LACPJ Length = 392 Score = 154 bits (388), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 117/373 (31%), Positives = 177/373 (47%), Gaps = 33/373 (8%) Query: 53 DAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSV 112 DA+ I RS TE + ++ + +V G G N + +D A G VFN P SN +V Sbjct: 31 DAYLI--RSVNLHTETLPSSLKVIVRAGA---GVNNIPIDQATANGTAVFNTPGSNANAV 85 Query: 113 AELVIGELLLLLRGVPEANAKA---------HRGVWNKLAAGSFEARGKKLGIIGYGHIG 163 EL+IG L++ R + A + R +K E GK L +IG GH+G Sbjct: 86 KELIIGLLIMASRNLIAATTYSAQHTEADISQRTEHDKTQFNGIELTGKTLAVIGLGHVG 145 Query: 164 TQLGILAESLGMYVYFYD--IENKLPLGNATQVQH---LSDLLNMSDVVSLHVPENPSTK 218 + A SLGM V YD + A QVQ L D + +D V++HVP+N T Sbjct: 146 ALVANAALSLGMNVIGYDPYLSADAAWNIAKQVQRAATLPDAVKQADFVTVHVPKNADTL 205 Query: 219 NMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFT 278 +++ ++ M G L N SR +VD A+ +ALA+ +A D F Sbjct: 206 HLINKDALAAMPTGVQLFNYSRLGIVDNTAVMNALATGQVAHYYTD------------FG 253 Query: 279 SP-LCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGG 337 P L V +TPHIGGST EA+ N + A ++ Y + G+ +A+N P++++P + Sbjct: 254 EPQLANQSAVTVTPHIGGSTIEAEINGATQAARTIMTYLETGNVHAAINLPDLNVPFNAA 313 Query: 338 RRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQA- 396 R IHEN P +++ + A +NI Q+ Y +ID++ + + L A Sbjct: 314 YRFTVIHENVPNMVSQITAKLAAANLNITTMANAAKHQIAYTIIDVDDLQQPQQADLIAE 373 Query: 397 MKAIPGTIRARLL 409 + IP R RLL Sbjct: 374 LSKIPAVSRVRLL 386 >UniRef50_Q1K3M3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Desulfuromonas acetoxidans DSM 684 RepID=Q1K3M3_DESAC Length = 528 Score = 154 bits (388), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 98/300 (32%), Positives = 162/300 (54%), Gaps = 9/300 (3%) Query: 36 EFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAA 95 ++ G D LK I + + +R T ++E++I AA++L I IG + +DAA Sbjct: 26 DYQPGITHDNLLK-IINNYDALIVRGGTTVSEELIFAAKRLKIIARAGIGVENIAMDAAN 84 Query: 96 KRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLG 155 +GI V N P +T ++AE I ++ L R +P+A+ +G W + K LG Sbjct: 85 IKGIVVTNTPLGSTTTIAEHAIAMMMSLARLIPQAHESMSQGKWQSTEFLGSDINDKTLG 144 Query: 156 IIGYGHIGTQLGILAESLGMYVYFYD---IENKLPLGNATQVQHLSDLLNMSDVVSLHVP 212 +IG G IG ++ A L M+V YD E + A++V L DLL+ +D +SLH+P Sbjct: 145 VIGGGKIGRRVIEYARGLHMHVNLYDPYLSEEVITRLGASKVS-LEDLLSTADFISLHLP 203 Query: 213 ENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPAT 272 T+ ++ A+ +++KPG LIN + G +++ L +AL AGAA+D F TEP Sbjct: 204 LTLETEQILNAETFAMVKPGCRLINCALGGLINEDDLVNALTDGTFAGAALDTFATEPPA 263 Query: 273 NSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSL 332 + L DNV+ TPH+ +T +AQ N+ ++ A ++I + N + +A+N P +S+ Sbjct: 264 PDN----RLLHMDNVICTPHLRAATVDAQTNVTVQAAHQVIDFLTNKTVRNALNVPSISI 319 >UniRef50_A0M1E7 D-3-phosphoglycerate dehydrogenase n=27 Tax=Bacteroidetes RepID=A0M1E7_GRAFK Length = 322 Score = 153 bits (387), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 108/326 (33%), Positives = 177/326 (54%), Gaps = 37/326 (11%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRD--AHFIGLRSRTHLTED 68 +K L +G+ Q +E+L+ AG+ E + EQLK+ + + + +RS T + +D Sbjct: 1 MKVLANDGISQSGVETLKNAGF---EVIVKKVAQEQLKDYLNENAISVLLVRSATKVRKD 57 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 +I+ L IG +G + +D++ A +G+ V N P +++ SVAELV L +R + Sbjct: 58 IIDNCIHLKVIGRGGVGMDNIDVEYARSKGVSVINTPAASSSSVAELVFAHLFGGVRKLY 117 Query: 129 EAN------AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVY---- 178 ++N + K AG E RGK LGI+G+G IG ++ +A +GM V Sbjct: 118 DSNRNMPLEGDSKFKDLKKAYAGGVELRGKTLGIVGFGRIGREVAKIALGIGMKVIASDK 177 Query: 179 ----------FYDIEN-KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEIS 227 FYD ++ K+P+ + + + L+ SD ++LHVP K ++GA+EI+ Sbjct: 178 NVGESEITLKFYDDQSIKIPV----KTEPVETLITKSDFITLHVP--AQAKPVIGAREIA 231 Query: 228 LMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNV 287 MK G +INA+RG V+D AL A+ S ++ AA+D + EP P L +++ Sbjct: 232 KMKDGVGIINAARGGVLDEEALLAAIESGKVSFAALDTYENEPT----PAIKLLMN-ESI 286 Query: 288 LLTPHIGGSTQEAQENIGLEVAGKLI 313 L+PHIG +T EAQE IG+E+A ++I Sbjct: 287 SLSPHIGAATNEAQERIGIELAEQII 312 >UniRef50_A7SFV8 Predicted protein (Fragment) n=1 Tax=Nematostella vectensis RepID=A7SFV8_NEMVE Length = 487 Score = 153 bits (386), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 95/289 (32%), Positives = 146/289 (50%), Gaps = 5/289 (1%) Query: 42 LDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPV 101 L E+L I + +RS T ++EDVI A + L IG G + +D AA+ G+ V Sbjct: 36 LSKEELVSEIPKYDGLIVRSATKVSEDVIKAGKNLKIIGRAGTGVDNIDTVAASLHGVLV 95 Query: 102 FNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGH 161 N P NT S AE + L R +P+A+A G W + E GK L IIG G Sbjct: 96 MNTPGGNTLSAAEHTCALISSLARHIPQASASTKEGKWERKQFMGNELFGKTLAIIGLGR 155 Query: 162 IGTQLGILAESLGMYVYFYD--IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKN 219 IG ++ + +S G+ YD + + + + + ++D +++HVP P TK Sbjct: 156 IGREVALRMQSYGVKTIGYDPLVSPQDAAESNIEWMETEKIWPLADYITVHVPLIPPTKG 215 Query: 220 MMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTS 279 M+ K I + K G ++N +RG ++D AL L S H+ GA +DVF TEP T S ++ Sbjct: 216 MLNDKTIGMCKKGVYILNVARGGIIDEEALLRGLESGHVGGAGLDVFVTEPPTGS---SA 272 Query: 280 PLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFP 328 L + V+ PH+G ST+EAQ + E+A + + + + VN P Sbjct: 273 DLVKHPKVIACPHLGASTEEAQRRVAQEIADQFVDGMNGKPLIGLVNVP 321 >UniRef50_Q6MN05 Phosphoglycerate dehydrogenase n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MN05_BDEBA Length = 328 Score = 152 bits (385), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 89/275 (32%), Positives = 147/275 (53%), Gaps = 6/275 (2%) Query: 49 ESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSN 108 E + AH + +RSRT + E+++ A +L I G + +DL+A K G+ V + P +N Sbjct: 39 EHLVSAHALIIRSRTKIDEELLKKARQLQLIVTCTSGFDHIDLEATQKWGVTVMHTPTAN 98 Query: 109 TRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGI 168 S A+L G +L + + A+ G WN+ E G+ GI+G G IG+++ Sbjct: 99 IESAAQLTWGLVLSCVNNIQAAHKMVKAGEWNRDQITGIELAGRNYGIVGLGRIGSRVAE 158 Query: 169 LAESLGMYVYFYDIENKLPLGNATQVQHLS--DLLNMSDVVSLHVPENPSTKNMMGAKEI 226 LA++ GM V YD + + + LS ++L +DV+S HVP+ T++M+ + Sbjct: 159 LAQAFGMNVVAYDPYQEDEVFERLHIPRLSYEEVLKTADVISFHVPKTLETEHMLNRSQF 218 Query: 227 SLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDN 286 + G +LIN SRG+V++ LC+AL L +DV+ EP + S L ++ N Sbjct: 219 EYIHRGIVLINTSRGSVINENDLCEALEKGWLRSVGLDVYEKEPLNRN----SNLLKYPN 274 Query: 287 VLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGST 321 ++LTPHIG +T++A A KL+ + +GST Sbjct: 275 LVLTPHIGANTEDAFFKASQIAANKLMAFFVDGST 309 >UniRef50_B3EF68 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=4 Tax=Bacteria RepID=B3EF68_CHLL2 Length = 305 Score = 152 bits (384), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 107/301 (35%), Positives = 160/301 (53%), Gaps = 20/301 (6%) Query: 19 VHQKALESLRAAGY--TNIEFHKGALDDEQLKESIRDAHFIGLRSRTH-LTEDVINAAEK 75 + K + L+ GY N F + +DE ++ + +G+ + L + V++ Sbjct: 14 IDPKPFDILKENGYEVINNPFGRKLTEDEVIEIA---KECVGIVAGVEPLNQKVMDNLPN 70 Query: 76 LVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAH 135 L I +G + VDLD A ++GI V N P TRSVAEL I L LLR VP+A+ Sbjct: 71 LRCISRVGVGMDSVDLDYAKQKGIVVTNTPDGPTRSVAELTIAMTLALLRKVPQAHMNIK 130 Query: 136 RGVWNK-LAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--ENKLPLGNAT 192 +GVW K + +E KK+G+IG G IG ++ G V +D+ E N Sbjct: 131 QGVWKKEIGNLMYE---KKVGLIGLGKIGKLAASQFQAFGCSVMAFDLYPETAWAEANDV 187 Query: 193 QVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDA 252 ++ + LL SD++SLH+P+ P T+ ++GA E+ MK GS LIN +R +V+ AL +A Sbjct: 188 EIVDMEKLLAESDIISLHIPK-PDTE-LIGAAELESMKEGSFLINIARDGIVNEGALYEA 245 Query: 253 LASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKL 312 L S LAGAAIDVF E P+ L E DN++LTPHIG +E + + ++ L Sbjct: 246 LKSNKLAGAAIDVFSKE------PYDGSLKELDNIVLTPHIGSYAKEGKLQMEIDAVNNL 299 Query: 313 I 313 + Sbjct: 300 L 300 >UniRef50_A1R7L8 D-3-phosphoglycerate dehydrogenase n=35 Tax=Actinobacteria (class) RepID=A1R7L8_ARTAT Length = 539 Score = 152 bits (384), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 102/269 (37%), Positives = 145/269 (53%), Gaps = 7/269 (2%) Query: 43 DDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVF 102 D QL +I D I +RS T + + I AA+ L I +G + VD+ +A + G+ V Sbjct: 43 DRSQLLSAIADVDAILVRSATQVDAEAIAAAKNLKVIARAGVGLDNVDIKSATQAGVMVV 102 Query: 103 NAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHI 162 NAP SN S AEL +G +L L R +P+A++ G W + E KK+GIIG G I Sbjct: 103 NAPTSNIVSAAELTVGHILSLARHIPQASSALKNGEWKRSKYTGIELFEKKIGIIGLGRI 162 Query: 163 GTQLGILAESLGMYVYFYD--IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNM 220 G + + + YD I ++ L +LL SD +++H+P+ P T M Sbjct: 163 GALVAARLQGFETEILAYDPYITAARAAQLGVKLVTLDELLENSDFITIHMPKTPETVGM 222 Query: 221 MGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSP 280 +GA MK + +IN +RG +VD AL AL +AGA +DVF EP+T+ P Sbjct: 223 LGADAFRKMKESAYVINVARGGLVDEEALYTALKEGQIAGAGVDVFVKEPSTD-----LP 277 Query: 281 LCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 EFDNV++TPH+G ST EAQE G+ VA Sbjct: 278 FFEFDNVVVTPHLGASTDEAQEKAGVSVA 306 >UniRef50_B1L3A6 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3A6_KORCO Length = 301 Score = 152 bits (384), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 91/273 (33%), Positives = 147/273 (53%), Gaps = 9/273 (3%) Query: 51 IRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTR 110 + DA + +R+ L D + A L I G + +D++ A +R + V AP R Sbjct: 26 LEDATVLIIRTDRKLDADDFSRAPMLKLIITATHGLDHIDIEEAKRRAVIVERAPV-RAR 84 Query: 111 SVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILA 170 +VAEL +G +L L RG+ ++ K W K FE G+++G+I G +G ++ + Sbjct: 85 AVAELALGIILALARGIAYSDRKMRGLEWVKGRVRGFELAGRRVGVISMGIVGREVAEVL 144 Query: 171 ESLGMYVYFYDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMK 230 + +GM+V +YD T + L LL SD+V L P T+ ++G +EI++MK Sbjct: 145 KGIGMHVDYYDRYR-------TGGRSLERLLRESDIVVLTSPLTEETRGLIGRREIAMMK 197 Query: 231 PGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLT 290 G++L+N RG ++D+ +AL + L G +DV+P EP + F L DNV+LT Sbjct: 198 DGAILVNVGRGELLDLDVALEALETGKLGGLGLDVYPREPPFGDEAFER-LRNMDNVILT 256 Query: 291 PHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLS 323 PH+GGS++EA+ I EV G + K+ S +S Sbjct: 257 PHLGGSSEEAERRIVSEVLGIMGKWFGRRSEIS 289 >UniRef50_A4EAR0 Putative uncharacterized protein n=3 Tax=Bacteria RepID=A4EAR0_9ACTN Length = 387 Score = 152 bits (384), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 108/355 (30%), Positives = 174/355 (49%), Gaps = 35/355 (9%) Query: 74 EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV------ 127 E + AI G N + ++ AK+G+ VFN+P +N+ +V ELV+G L+L RGV Sbjct: 48 EGIRAIARCGAGVNNIPVEEYAKKGVVVFNSPGANSNAVKELVLGMLVLSSRGVVQSMNW 107 Query: 128 -------PEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 PE A + K A E +GK++G+IG G++G+++ LGM VY Y Sbjct: 108 VRDNADDPEIQVDAEKA---KKAFVGRELKGKRIGVIGLGNVGSKVANACVDLGMDVYGY 164 Query: 181 D----IENKLPLGNATQ-VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLL 235 D +E+ L Q V L DL D +++HVP T M+ ++I+L+ P ++L Sbjct: 165 DPFISVEHAWVLSREVQRVGTLEDLCRGCDYLTVHVPSKADTIGMISTEQINLLAPDAVL 224 Query: 236 INASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGG 295 IN +R T++D A+ AL L+ + D F T P T P N +T H G Sbjct: 225 INYARETIIDEDAVDAALREGKLSWFSCD-FAT-PKTVKMP---------NTFITTHSGA 273 Query: 296 STQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSL-PLHGGRRLMHIHENRPGVLTAL 354 T EA+ N +L Y +NG+ +VN+P S+ R+ +H N P ++ + Sbjct: 274 GTGEAEANCADMAISELKDYLENGNIAHSVNYPACSMGKARAASRIACLHANVPNMIGQI 333 Query: 355 NKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 I A+ N+ +++ + Y + D DE + ++A+K IP R R++ Sbjct: 334 TAILAKDNANVQRMTNESAGENAYTMFD--TDEHLDSSTIEALKQIPSMYRVRVI 386 >UniRef50_A7NGZ0 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Roseiflexus RepID=A7NGZ0_ROSCS Length = 345 Score = 151 bits (382), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 106/290 (36%), Positives = 148/290 (51%), Gaps = 23/290 (7%) Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A L+AI IG + +DL AA +RGI V N P T S AE + +L L + V A Sbjct: 65 RAGPTLMAIARPGIGVDNIDLAAATERGILVINTPDGPTESTAEHAVALVLALAKQVVAA 124 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLG-ILAESLGMYVYFYDIENKLPLG 189 + + W+ E RGK LG++G G IG ++ I + LGM V YD PL Sbjct: 125 DHRFRTAGWSAARLRGVEVRGKTLGVVGLGRIGRRVAQICRQGLGMRVAAYD-----PLA 179 Query: 190 NA--------TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 A V+ L +LL S+ ++LH PST+ ++GA+E++L+ G+ LIN SRG Sbjct: 180 PAEAFAALDVVHVETLDNLLPQSEFLTLHCALTPSTRGLIGARELALLPKGAFLINVSRG 239 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 V+D AL DAL + HLAGA +DVF EP N PL +F +V+LTPHI T + Sbjct: 240 AVIDQAALIDALTTGHLAGAGLDVFDPEPLPND----HPLLQFPHVILTPHIASFTDDGV 295 Query: 302 ENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVL 351 + ++++ VN PE +LP GRR H +P L Sbjct: 296 RVMHHGAVAQIVRLLRGEHPPHIVN-PE-ALP---GRRAKMNHGTQPDAL 340 >UniRef50_B2I1D3 Phosphoglycerate dehydrogenase n=2 Tax=Acinetobacter baumannii RepID=B2I1D3_ACIBC Length = 325 Score = 151 bits (381), Expect = 5e-35, Method: Compositional matrix adjust. Identities = 92/265 (34%), Positives = 141/265 (53%), Gaps = 7/265 (2%) Query: 45 EQLKESIRDAHFIGLRSRT-HLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFN 103 +++++ I D + RT L+ D+I A++ L I +G + +D AAA+R IPV Sbjct: 37 DKMEKLIHDEQPDAIIVRTGKLSRDMIFASDNLKVIAKHGVGFDTIDTQAAAERKIPVTI 96 Query: 104 APFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIG 163 A +N +SVAE + + R V + + G W+K +A E GK LG+IG G IG Sbjct: 97 AVGANAQSVAEHAFALMFNVARQVTWLDQRIREGHWDKASANGVELYGKTLGLIGLGAIG 156 Query: 164 TQLGILAESLGMYVYFYD--IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMM 221 + L L L M V YD ++N L Q L+ SD++SLH P K++ Sbjct: 157 SILMKLVAPLNMKVKVYDPFLQNLPELDYVEQEHDFEKLIETSDIISLHCPLTAENKHLF 216 Query: 222 GAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPL 281 + MK S+LIN +RG ++D AL DAL + +AGA +D F +EP + PL Sbjct: 217 SHSQFEKMKSSSILINTARGELIDQAALVDALKNNKIAGAGLDTFSSEPPEKDN----PL 272 Query: 282 CEFDNVLLTPHIGGSTQEAQENIGL 306 E N+++TPHIG +T +++ +GL Sbjct: 273 WELPNLVVTPHIGANTTDSRNRVGL 297 >UniRef50_A3MTB6 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=4 Tax=Archaea RepID=A3MTB6_PYRCJ Length = 334 Score = 151 bits (381), Expect = 5e-35, Method: Compositional matrix adjust. Identities = 86/223 (38%), Positives = 128/223 (57%), Gaps = 3/223 (1%) Query: 85 GTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNK--L 142 G + +D++A A+RGIPV N +N SVAE I L+LL+ A+ + G W + L Sbjct: 88 GYDHIDVEACARRGIPVANIGGANAISVAEHTIMLALMLLKRAVYAHRRLLEGQWTQGEL 147 Query: 143 AAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI-ENKLPLGNATQVQHLSDLL 201 E GK G++G G IG ++ + A +LG V +YD+ N+ + + + LL Sbjct: 148 MNVIGEVFGKTWGVLGMGRIGREVAVRAMALGAKVIYYDVVRNEEMEKRGAEYRPFNRLL 207 Query: 202 NMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGA 261 SD++S+HVP P+T+ M+G +E+ LMKP +++IN SRG +VD AL A+ +AGA Sbjct: 208 AESDILSIHVPLTPATRKMIGERELRLMKPTAVVINVSRGEIVDEEALAKAVREGWIAGA 267 Query: 262 AIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 +DVF EP P E NV++TPHI G+T EA+ I Sbjct: 268 GVDVFSVEPPPPDHPLIQAAREGYNVVVTPHIAGATNEARMRI 310 >UniRef50_C0BYY9 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM 15053 RepID=C0BYY9_9CLOT Length = 330 Score = 151 bits (381), Expect = 5e-35, Method: Compositional matrix adjust. Identities = 100/286 (34%), Positives = 147/286 (51%), Gaps = 13/286 (4%) Query: 45 EQLKESIR--DAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVF 102 +QL E + DA +GL TE+V A +L I F +GT+ +D D A + GI V Sbjct: 48 QQLAEVVGNIDAAVVGL---DEWTEEVFRMAPRLKVIAKFGVGTDNIDCDTAKEYGIKVI 104 Query: 103 NAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHI 162 NAP N+ +VAEL +G ++ LLR + +G W + G E +GK +G+ G+G + Sbjct: 105 NAPGQNSNAVAELTVGFMIQLLRNILPLYEGIRQGQWVRYIGG--ELKGKTVGLFGFGAV 162 Query: 163 GTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLS--DLLNMSDVVSLHVPENPSTKNM 220 + S V D+ V +S +++ SD++S+H+P +T ++ Sbjct: 163 AKLVAKKLSSFETEVIACDLHPDSEYAKKYNVGLVSAEEVVERSDILSVHLPATSATYHL 222 Query: 221 MGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSP 280 + IS MK G+ +IN +RG VVD AL +AL S +LAGAA+D F TEP P S Sbjct: 223 VDKAMISKMKRGACMINCARGAVVDTEALTEALKSGYLAGAALDAFETEPL----PADSL 278 Query: 281 LCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVN 326 L DNV+ TPH G T EA N+ L A ++ + L VN Sbjct: 279 LLTCDNVICTPHTGAETYEAYRNVSLCTAQGILDVLEGREPLYWVN 324 >UniRef50_B5XZV2 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=9 Tax=Enterobacteriaceae RepID=B5XZV2_KLEP3 Length = 342 Score = 150 bits (380), Expect = 7e-35, Method: Compositional matrix adjust. Identities = 105/310 (33%), Positives = 148/310 (47%), Gaps = 42/310 (13%) Query: 39 KGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRG 98 K L QL E DA + + S +T+ V+ A +L I C +D AA RG Sbjct: 31 KPKLSAGQLIELAHDAEVL-VTSYDEVTDAVMAACPRLQVIACTRANPVNIDTQAAQARG 89 Query: 99 IPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRG--------------------V 138 I V P N + AEL +G +L L R +P+++A RG V Sbjct: 90 IRVLYTPGRNADAAAELTLGLMLSLARHIPQSHAALKRGEFTQADNAAAATQQGLRRDVV 149 Query: 139 WNKLAAGSFEA------RGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNAT 192 W+ +E R K LG++GYG+IG ++ +A + GM V D P A Sbjct: 150 WDVSPESPYEVFKGSELRNKTLGLVGYGNIGRRVARIARAFGMAVLVVD-----PFVAAE 204 Query: 193 QVQH-------LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 + L L +D+VSLH+ P + ++ A ++ MKPG+LLIN SR VVD Sbjct: 205 DINEPGLQKTTLEALFREADIVSLHLSSGPHSDGLVNAALLNSMKPGALLINTSRAAVVD 264 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL DAL L GAA+DV+ EP PF + EFDNV++TPHI G+T+E+ Sbjct: 265 EAALIDALRHGPLGGAALDVYHREPLWRDHPFVT---EFDNVIITPHIAGATRESIAKHT 321 Query: 306 LEVAGKLIKY 315 +A L +Y Sbjct: 322 AMIAADLQRY 331 >UniRef50_A6Q7Q2 D-3-phosphoglycerate dehydrogenase n=49 Tax=Epsilonproteobacteria RepID=A6Q7Q2_SULNB Length = 529 Score = 150 bits (379), Expect = 8e-35, Method: Compositional matrix adjust. Identities = 104/304 (34%), Positives = 163/304 (53%), Gaps = 22/304 (7%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALD--DEQLKESIRDAHFIGLRSRTHLTE 67 K ++ + +HQ L+ L A + I+ A + D+ + E I A RS T + Sbjct: 3 KKTIVVCDHIHQSGLDIL--ANDSEIKLINAADEPKDKLIAEIIPLADVAITRSSTDVDA 60 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 + +A+K+ AI +G + VD+ ++K+GI V N P +NT + EL + +L +R Sbjct: 61 AFLESAKKITAIVRAGVGVDNVDIPGSSKQGIVVMNVPTANTIAAVELTLAHMLSCVRQF 120 Query: 128 PEA--NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD---- 181 P A N K R VW + E + KKLGIIG+G+IG+++G A++ M V YD Sbjct: 121 PYAHNNLKLDR-VWRRQDWYGTELKDKKLGIIGFGNIGSRVGKRAKAFEMDVLAYDPYID 179 Query: 182 --IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINAS 239 L +G ++ D+L D++++H P+ T M+ EI+ MK G +LIN + Sbjct: 180 PSKATDLDIG---YTKNFEDIL-ACDIITIHTPKTEETIGMINKDEIAKMKDGVILINCA 235 Query: 240 RGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQE 299 RG + + AL + L S +A A IDVF EPAT+ PL + DNV +TPH+G +T+E Sbjct: 236 RGGLYNEEALLEGLKSGKIAMAGIDVFNKEPATD-----HPLLDLDNVTVTPHLGANTKE 290 Query: 300 AQEN 303 +Q N Sbjct: 291 SQRN 294 >UniRef50_A5N5A9 SerA n=3 Tax=Clostridium RepID=A5N5A9_CLOK5 Length = 320 Score = 150 bits (379), Expect = 8e-35, Method: Compositional matrix adjust. Identities = 105/303 (34%), Positives = 161/303 (53%), Gaps = 13/303 (4%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ E + ++ +E L+ GY I+ + +D L E ++D I +R ++TE VI Sbjct: 4 KILITESIEEEGVEYLKKFGY-EIKMPRDTSED-VLIEEVKDCDAILVR-MANITEKVIR 60 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A +KL I F +G N VD+ A++ I + NAP SN +VAE +G ++ L + + Sbjct: 61 AGKKLKVISRFGVGVNNVDIKTASELSIQITNAPESNKNTVAEYTMGLIIALAKKFFLYD 120 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILA-ESLGMYVYFY----DIENKL 186 +G + + GK LGI+G G IG L + A + GM V + D E+K Sbjct: 121 RGLRKGNFKVRDILGIDLEGKVLGIVGLGSIGKLLALKASKGFGMKVIGFKRHIDEESK- 179 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 L L +L SD VSL+VP +T ++G +E+S MK + LIN +RG VVD Sbjct: 180 SLDYVELTDSLDYVLENSDFVSLNVPLTKATTKIIGKRELSFMKKDAFLINTARGEVVDN 239 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 ALC+AL +K +AGAA DVF E + + P+ + +NV++TPH T EA + + + Sbjct: 240 DALCNALLNKQIAGAATDVFDGEIPSKDN----PIFKMENVIVTPHSAAHTIEAMKRMSV 295 Query: 307 EVA 309 A Sbjct: 296 HAA 298 >UniRef50_Q4WHR3 D-3-phosphoglycerate dehydrogenase n=3 Tax=Eurotiomycetidae RepID=Q4WHR3_ASPFU Length = 635 Score = 150 bits (378), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 112/379 (29%), Positives = 182/379 (48%), Gaps = 58/379 (15%) Query: 4 VSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRT 63 +S ++ K L+ E + L LRA+ ++ +G LD ++L + I + + +RS T Sbjct: 2 LSAKQPPPKVLVPEKLSPDGLALLRAS--LEVDERRG-LDADELLQIIPEYEALVVRSET 58 Query: 64 HLTEDVINAAEKLVAI------------------------GCFCIGTNQVDLDAAAKRGI 99 +T +++ AA++L + G + + +++ D++ A K GI Sbjct: 59 KVTANLLRAAKQLKVVARAGVGVDNVGELAQPPLPPSPSLGSWPLTSHRTDVEEATKLGI 118 Query: 100 PVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGY 159 V N+P N + AE I L+ + R +PEA + G W + E +GK L IIG Sbjct: 119 VVVNSPSGNIGAAAEHTIALLMAMARNIPEACSSLKSGKWERSKFVGVEVKGKTLSIIGL 178 Query: 160 GH---------------------------IGTQLGILAESLGMYVYF---YDIENKLPLG 189 G +G + LA+ LGM+V Y Sbjct: 179 GKGELLAIWGRGIHFRYDGGSSGWADRQTVGLTVARLAKGLGMHVNALDPYASPAVAASA 238 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 + T V LS+LL +D +++H P STK M+ E++ MKPG+ ++N +RG +D AL Sbjct: 239 SVTLVSSLSELLPTADFLTIHTPLIASTKGMISTAELAQMKPGARILNVARGGTIDEAAL 298 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 ++L S HLA AAIDVF TEP + + L ++TPH+G ST EAQEN+ ++V Sbjct: 299 LESLESGHLAAAAIDVFTTEPP-QPESTAARLVAHPRAVVTPHLGASTVEAQENVSIDVC 357 Query: 310 GKLIKYSDNGSTLSAVNFP 328 ++++ + SAVN P Sbjct: 358 EQVLQILNGSLPRSAVNAP 376 >UniRef50_B0PHF7 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PHF7_9FIRM Length = 319 Score = 149 bits (377), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 92/265 (34%), Positives = 138/265 (52%), Gaps = 15/265 (5%) Query: 53 DAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSV 112 D IG+ E V A KL + F +G + +DL+AA + G+ V NA N +V Sbjct: 52 DGAIIGM---DQWNEQVFQIAPKLKILARFGVGVDNIDLEAAKRHGVQVVNAAGMNANAV 108 Query: 113 AELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAES 172 AEL + +L LRG+PE N K G W++ A + GK +G++G+G IG ++ Sbjct: 109 AELAVAMILNCLRGIPELNRKLTDGQWSR--AVGRDLLGKTVGLLGFGDIGGRVAKKLSG 166 Query: 173 LGMYVYFYDI----ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISL 228 + + YD E LG + L +L SD++S+H+P P+T+++M + + Sbjct: 167 FEVRLLAYDPYPNREKAAALG--VTLTDLDTVLTQSDILSIHMPSIPATRHVMNRETFAK 224 Query: 229 MKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVL 288 MKP S IN +RG +VD AL DA+A HLAGAA+DV+ EP P +P+ + Sbjct: 225 MKPDSYFINTARGALVDTQALVDAVAGGHLAGAAVDVYEQEPL----PMGAPILHTPGIQ 280 Query: 289 LTPHIGGSTQEAQENIGLEVAGKLI 313 PH G T+E NI + A +I Sbjct: 281 CIPHAGAETRETYSNISMMTAQAVI 305 >UniRef50_B2KCL9 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Elusimicrobium minutum Pei191 RepID=B2KCL9_ELUMP Length = 315 Score = 149 bits (377), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 107/321 (33%), Positives = 170/321 (52%), Gaps = 12/321 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIR--DAHFIGLRSRTHLTED 68 +K L+ + + +E L+ G+ I ALD+ L E+ + A I +RS T + Sbjct: 1 MKILIADKFPKHWVEVLKEKGHEII--LNPALDENTLPEAQKTEQAEIIIVRS-TKVNAS 57 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 I+AA L + G + +D++ A +G+ V N P +N+ +VAEL +G +L L R +P Sbjct: 58 AIDAAPSLKLVIRAGAGYDTIDINHAKTKGVAVCNCPGTNSIAVAELAMGLILSLDRRIP 117 Query: 129 EANAKAHRGVWNKLAAGSFEA-RGKKLGIIGYGHIGTQLGILAESLGMYVYFYD-IENKL 186 + G WNK + G+ LGIIG GHIG ++ A++ G+ + +D + Sbjct: 118 DNIIDLKAGKWNKTEYSKAKGLYGRTLGIIGLGHIGREVAKRAQAFGLKIIAFDPFVKES 177 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 PL A V + DL +D++++HVP TK+ K MKPG+ IN SRG +V Sbjct: 178 PL--AQMVSDVYDLAKKADIITIHVPNTAGTKHFYDEKFFEAMKPGAYFINTSRGGLVKE 235 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL A A K + AA+DV+ EP ++ F P+ N+ T HIG ST++AQ+ + Sbjct: 236 DALIKACAEKGIR-AALDVYEKEPKADAKEFVDPVTSAVNIYGTHHIGASTEQAQDAVA- 293 Query: 307 EVAGKLIK-YSDNGSTLSAVN 326 EVA ++++ +D G+ L VN Sbjct: 294 EVAVQIVQELADKGTFLHQVN 314 >UniRef50_Q2WB35 Phosphoglycerate dehydrogenase and related dehydrogenase n=5 Tax=Proteobacteria RepID=Q2WB35_MAGSA Length = 318 Score = 149 bits (377), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 94/243 (38%), Positives = 136/243 (55%), Gaps = 9/243 (3%) Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 L E V++ L +G + +G + +DL A ++ G + N RSV+ELVI + LL Sbjct: 63 LDEAVLSRLPDLKVVGKYGVGLDMIDLAAMSRLGKRLGWTGGVNRRSVSELVIAFAIALL 122 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 R +P+ NA G W +L R +GI+G GHIG L L ++ G V +DI + Sbjct: 123 RHIPQGNALIRDGGWRQLMGRQLSER--TVGIVGCGHIGKDLSRLLKAFGCRVLAHDIRD 180 Query: 185 KLPLGNATQVQH--LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 AT V+ L LL +D+V+LH+P + ST+N++ A+ ++LM+ ++LINA+RG Sbjct: 181 FPEFYAATGVEKMDLEPLLAEADIVTLHLPFDASTRNILSAERLALMRSDAILINAARGG 240 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 +VD AL LA+ LA AA DVF TEP P L E N L TPH+GGS +EA Sbjct: 241 LVDEAALRVMLATGRLAAAAFDVFATEP-----PEDRALIELPNFLCTPHVGGSAEEAVL 295 Query: 303 NIG 305 +G Sbjct: 296 AMG 298 >UniRef50_C8WP48 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=53 Tax=Bacteria RepID=C8WP48_EGGLE Length = 391 Score = 149 bits (376), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 113/387 (29%), Positives = 189/387 (48%), Gaps = 36/387 (9%) Query: 43 DDEQLKESIRDAHFIGLRSRT-HLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPV 101 DD +L +++ A + +RS H T + L+AI G N + LD A+ GI V Sbjct: 20 DDYELIDALDQAEGVLVRSAALHDTA----FPDSLLAIARAGAGVNNIPLDRCAEEGIVV 75 Query: 102 FNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNK----------LAAGSFEARG 151 FN P +N +V E+V+ L+L R + A ++ A E +G Sbjct: 76 FNTPGANANAVKEIVVCGLMLGSRDIAGGIAWCRHNADDENIAKAAEKAKKAFAGREVKG 135 Query: 152 KKLGIIGYGHIGTQLGILAESLGMYVYFYD----IENKLPLGNATQ-VQHLSDLLNMSDV 206 KKLG+IG G IG ++ +A LGM VY YD + + +A V +L D+ Sbjct: 136 KKLGVIGLGAIGAEVANIAIDLGMDVYGYDPYVSVGAAWRISSAVHHVTNLDDIFRTCGY 195 Query: 207 VSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVF 266 +++HVP T M+ + SLMK G++ +N SR T+VD A+ AL S + D Sbjct: 196 MTIHVPAMDGTIGMIDERACSLMKDGAVFLNFSRDTLVDNAAMAAALDSGKVHAYITD-- 253 Query: 267 PTEPATNSDPFTSP-LCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAV 325 F +P + + + ++ PH+G ST EA++N + +L+ Y +NG+ ++V Sbjct: 254 ----------FATPEVMKMERAIVLPHLGASTAEAEDNCAMMAVRELMDYLENGNIANSV 303 Query: 326 NFPEVSL-PLHGG-RRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDI 383 N+P + P+ G RR+ +H N P + + +F + GVNI + + Y ++D+ Sbjct: 304 NYPACDMGPVPDGLRRVAVLHANVPNAIARITNVFGDAGVNIENMMNKARGENAYTMLDL 363 Query: 384 EADE-DVAEKALQAMKAIPGTIRARLL 409 +A + A++ + AI G R R++ Sbjct: 364 DAGTPGHPDDAIERLSAIEGVRRVRVV 390 >UniRef50_UPI000197AFFA hypothetical protein BACCOPRO_00987 n=1 Tax=Bacteroides coprophilus DSM 18228 RepID=UPI000197AFFA Length = 315 Score = 149 bits (375), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 108/290 (37%), Positives = 156/290 (53%), Gaps = 10/290 (3%) Query: 30 AGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQV 89 AG+T + + LD + E R+A I + + L +VI A + L I G + V Sbjct: 26 AGHTFNAYPRD-LDIQVQIERAREADVI-IIANMPLRGEVIRACKHLKFIDVAFTGVDHV 83 Query: 90 DLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEA 149 DLDAA + G+ V NA +T++VAEL + +L LLR VP+ + +G G E Sbjct: 84 DLDAARECGVKVSNAAGYSTQAVAELALCMMLSLLRNVPQVAGRCRQGKTKDGLVGC-EL 142 Query: 150 RGKKLGIIGYGHIGTQLGILAESLGMYVY--FYDIENKLPLGNATQVQHLSDLLNMSDVV 207 RGK +GI+G G IGT+ L ++ G V + K P + + L +LL+ SD+V Sbjct: 143 RGKTVGIVGAGAIGTRTAELCKAFGCRVLGNKRHLTGKEP--SFIEFMPLEELLSQSDIV 200 Query: 208 SLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFP 267 SLH P T+ ++ A + +MK G+ LIN +RG VVD AL +AL + +LAGA IDVF Sbjct: 201 SLHCPLTAETRQLINADRLGMMKQGAYLINTARGGVVDSAALAEALKNGYLAGAGIDVFE 260 Query: 268 TEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSD 317 TEP DP PL + NVL TPH+ +++E+ E V L + D Sbjct: 261 TEPPL--DP-AHPLLQAPNVLATPHVAFASEESMEARAAIVFSNLSNWMD 307 >UniRef50_B8FRV3 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Desulfitobacterium hafniense RepID=B8FRV3_DESHD Length = 320 Score = 149 bits (375), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 99/289 (34%), Positives = 147/289 (50%), Gaps = 10/289 (3%) Query: 40 GALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGI 99 G + E K + +AH + ED + AA L I G + +DL AAA RGI Sbjct: 38 GLREREDFKAVLAEAHVWVVGINKVYAED-LEAAPNLKLIIKHGTGVDSIDLKAAAARGI 96 Query: 100 PVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGY 159 V NAP +N SVA+L G +L L R + A+ + G W + + GK LG++G Sbjct: 97 TVANAPGTNANSVADLAFGFMLSLARQIVSADKRTRDGFWGTVMGK--DVYGKTLGVLGL 154 Query: 160 GHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQ--HLSDLLNMSDVVSLHVPENPST 217 G IG + A M + YD+ + +V+ L ++++ +D +S+H+P ST Sbjct: 155 GQIGKGVIRRASGFDMNILGYDLVHHSQFEKEYRVRAATLEEIMSEADYISVHLPLLEST 214 Query: 218 KNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPF 277 KN++ + M+P + LIN SRG VVD AL D L K +AGAA+DVF TEP P Sbjct: 215 KNIIDRSLLEKMRPTAFLINTSRGGVVDETALYDLLKEKRIAGAALDVFATEP-----PR 269 Query: 278 TSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVN 326 SP E DNV++ PH+G T+ A + +A +++ LS + Sbjct: 270 QSPFFELDNVIVAPHMGAYTEGAMGAVSEILAESIVRVLAGKEPLSVIK 318 >UniRef50_A1RDF9 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=1 Tax=Arthrobacter aurescens TC1 RepID=A1RDF9_ARTAT Length = 329 Score = 149 bits (375), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 97/294 (32%), Positives = 154/294 (52%), Gaps = 11/294 (3%) Query: 19 VHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVA 78 +H+ L +R ++ + ++ + E+I + LR+ T T ++I A+ +L Sbjct: 10 IHEDVLADIRKNAIVHVGYGPDKVNYLDISENIDG---VILRAET-FTREMIEASPRLKI 65 Query: 79 IGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGV 138 I +GT+ VD+ AA++ + V + P SN+ +VAE V LL L R + A + G Sbjct: 66 IARHGVGTDNVDIPAASEHSVWVTSTPGSNSNAVAEHVFSLLLSLTRRIIPAANRVLAGT 125 Query: 139 WNKLAAG--SFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IENKLPLGNATQV 194 W + FE G+ LGI+G+G IG ++ +A GM V D + Sbjct: 126 WAEGRGDLVGFELSGRTLGIVGFGAIGKRVATIANGFGMRVLASDPIATAADAEAAGAVL 185 Query: 195 QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALA 254 L L + +D+++LH P T++M+ +E+++MKP +++IN SRG ++D AL AL Sbjct: 186 VELDTLYDGADIITLHAPLLSGTRHMISPRELAMMKPSAIIINTSRGGLIDEDALVTALT 245 Query: 255 SKHLAGAAIDVFPTEPATNSDPFTS---PLCEFDNVLLTPHIGGSTQEAQENIG 305 + LAGAA+DV E DP T PL E N+L+TPHI G TQEA + G Sbjct: 246 NGTLAGAALDVLEAESIDMKDPLTHNSVPLHEVPNLLVTPHIAGQTQEAFQEAG 299 >UniRef50_Q7D366 Putative phosphoglycerate dehydrogenase n=1 Tax=Agrobacterium tumefaciens str. C58 RepID=Q7D366_AGRT5 Length = 317 Score = 148 bits (374), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 92/255 (36%), Positives = 138/255 (54%), Gaps = 20/255 (7%) Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 E V N A +L AI F +G + +D+DAA + GI V NAP N +VAEL +G +L +R Sbjct: 63 ERVFNLAPRLKAIARFGVGVDNIDIDAAHRHGIAVTNAPGGNANAVAELTLGLILSAMRR 122 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL 186 +P + G W++ E G+++G++G+G+I ++ + V YD K Sbjct: 123 IPYLHDALRGGAWDRFVGQ--ELIGRRVGLLGFGNIARKIARKLCGFDVEVIAYD---KF 177 Query: 187 P-------LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINAS 239 P LG ++ + ++L+ SD++ + +P P T+ +M A + MKPGS+ IN + Sbjct: 178 PDQVAATKLG--VRMCEMDEVLSSSDILVMMMPSLPETRRLMDAGRFARMKPGSIFINTA 235 Query: 240 RGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDP-FTSPLCEFDNVLLTPHIGGSTQ 298 RG +VD AL DAL S HL AAIDV+ TEPA +P FT P ++ TPH T Sbjct: 236 RGALVDEKALYDALVSGHLQAAAIDVYETEPALPDNPLFTLP-----QIVTTPHTAAETY 290 Query: 299 EAQENIGLEVAGKLI 313 E +IG A +I Sbjct: 291 ETYTSIGRITAEAVI 305 >UniRef50_UPI0001972FE9 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=1 Tax=Clostridium sp. M62/1 RepID=UPI0001972FE9 Length = 338 Score = 148 bits (373), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 110/311 (35%), Positives = 160/311 (51%), Gaps = 17/311 (5%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + LL + + + + L GY ++ ++E + IR + +R+ +T+ ++ Sbjct: 3 FRILLPQPILESGRQYLLERGYELVD--GSGFEEEDIIRDIRGCDAMIVRT-AKITDRIL 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA++L I G + VDL+AA K+GI V AP +N++SVAEL + +L R Sbjct: 60 EAADRLKVIARHGAGFDGVDLEAARKKGILVLYAPKANSQSVAELAVFYILHCSRNFKLV 119 Query: 131 NAKAHRGVWN--KLAAGSFEARGKKLGIIGYGHIGTQLGILAE--SLG--MYVYFYDIEN 184 K +R + K E GK LG+IG G+IG G++A+ +LG M V +D Sbjct: 120 Q-KLYRDDYRFAKFNVEKHELNGKTLGLIGVGNIG---GLVAKKAALGFDMKVIAFDPYA 175 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 K + ++ +D VSLHVP P T N +G KE LMKP + LIN SRG+VV Sbjct: 176 KELPDYIEVAESREEVFEKADYVSLHVPATPETVNSVGEKEFRLMKPTAFLINTSRGSVV 235 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL AL K +AGAA+DV EP + PL E DNV+ PHIG +T+EA Sbjct: 236 DEEALIRALNEKEIAGAALDVLKQEPIDKDN----PLLEMDNVVTAPHIGAATKEASARA 291 Query: 305 GLEVAGKLIKY 315 L A + Y Sbjct: 292 SLICAQGIDDY 302 >UniRef50_Q0W672 Glycerate dehydrogenase n=2 Tax=Archaea RepID=Q0W672_UNCMA Length = 319 Score = 148 bits (373), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 89/235 (37%), Positives = 126/235 (53%), Gaps = 12/235 (5%) Query: 85 GTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAA 144 G + VDLDAA +G+ V NAP + +VAE V LL +R + EA+ ++ A Sbjct: 75 GYDDVDLDAATLKGVAVANAPGYSNEAVAEHVFAMLLSFIRRISEADFWIREEKFDCTAF 134 Query: 145 GSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLLNMS 204 E RGK +GIIG G IG ++ +A GM V YD+ + + L L S Sbjct: 135 EGRELRGKTMGIIGTGQIGLRVAEIARCFGMDVIAYDVRRNPAVAEKLRYVGLDRLCAES 194 Query: 205 DVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAID 264 D +++H+P T+ ++ + LMKPG+++IN +RG VVD AL AL +AGA +D Sbjct: 195 DFITVHLPLTSDTRGLIDEESFRLMKPGAVIINTARGPVVDQAALLRALDEGRIAGACLD 254 Query: 265 VFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ--------ENIGLEVAGK 311 VF EP P SPL N LLTPHI +T+EA+ EN+ L ++GK Sbjct: 255 VFDQEPL----PPDSPLLAMSNTLLTPHIAYNTREAKEQSIAIAAENVALYLSGK 305 >UniRef50_UPI0001BC4ADC hypothetical protein FulcA4_06865 n=1 Tax=Fusobacterium ulcerans ATCC 49185 RepID=UPI0001BC4ADC Length = 319 Score = 147 bits (372), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 106/320 (33%), Positives = 165/320 (51%), Gaps = 10/320 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + V ++ +E L++ G+ I+ GA +E L + + D I LR+ TE V+ Sbjct: 4 KVLIPQAVAKEGVELLKSYGF-EIKHGSGA-SEEDLIKDVADCDAILLRT-APCTEAVLK 60 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A + L + G N VDL+AAAK GI NAP S T +VAE V+G +L + + + N Sbjct: 61 AGKNLKIVARHGAGYNNVDLEAAAKLGIWATNAPDSTTNTVAEFVLGAILAVSKRIFLMN 120 Query: 132 AKAHRG-VWNKLAAGSFEARGKKLGIIGYGHIGTQLGILA-ESLGMYVYFYD-IENKLPL 188 K G + K + GKKLG++G+G IG ++ A LGM + YD K Sbjct: 121 KKIKEGDFFFKNNHKGMDLTGKKLGVVGFGRIGRKVAYKAFYGLGMEILAYDPFLTKENC 180 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + + + SD++SLH+P +G KE + MK + IN +RG VV+ Sbjct: 181 PDYVTICDWETIFKESDIISLHMPLIKENIGCVGKKEFTNMKKSAHFINCARGEVVNEKE 240 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +AL ++ +AGA +DVF EP +P S DNV++TPH+ +T+E + ++ Sbjct: 241 LIEALKTEEIAGAFLDVFEQEPPLEDNPLLS----MDNVIVTPHMASNTEECMILMAVQA 296 Query: 309 AGKLIKYSDNGSTLSAVNFP 328 A +++K N VN P Sbjct: 297 ASEIVKVLSNEKPCWPVNNP 316 >UniRef50_Q01ZI8 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=3 Tax=Bacteria RepID=Q01ZI8_SOLUE Length = 400 Score = 147 bits (371), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 119/389 (30%), Positives = 184/389 (47%), Gaps = 18/389 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 ++ L+ + Q E L A G + F L DE L + L R+ + + Sbjct: 1 MRILIADEFEQSGREQLNALG-CEVRFAP-KLKDEALVAEVDSFRPDVLVVRSTKVPEAV 58 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA L + G N +D+ AA++RGI V N P N+ +VAEL G +L L R + + Sbjct: 59 LAAGALKLVVRAGAGHNTIDVGAASRRGIYVSNCPGKNSVAVAELAFGLILALDRQIADN 118 Query: 131 NAKAHRGVWNKLAAGSFEARG---KKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP 187 G WNK +G +ARG + LG+IG G IG ++ A + G+ V + Sbjct: 119 VIALREGRWNK--SGFSKARGLFGRTLGLIGVGQIGREMIPRARAFGLPVVAWSRSLTPE 176 Query: 188 LGNATQVQHL---SDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 A V++ +++ +D+VS+HV NP TK M+ A+ I+ ++PG+ IN SR VV Sbjct: 177 SAKALGVEYKPSPAEVAAAADIVSVHVALNPQTKGMLNAEWIAALRPGAYFINTSRAEVV 236 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL A+ K + A +DVF EPA + F + + + V T HIG ST++AQE I Sbjct: 237 DQEALSRAVTEKGIR-AGLDVFAKEPAGGAGDFADEIVKLNGVYGTHHIGASTEQAQEAI 295 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVN 364 E + + G + VN + L+ H +RPGVL A+ G+N Sbjct: 296 AAETVRIIRTFLQTGKVPNVVNLARTTPATCA---LVVRHLDRPGVLAAVLDSVRAAGIN 352 Query: 365 IAAQ----YLQTSAQMGYVVIDIEADEDV 389 + + A + + ++ DEDV Sbjct: 353 VQEMENIIFEGAEAAVARIHLETVPDEDV 381 >UniRef50_Q5WLJ2 D-3-phosphoglycerate dehydrogenase n=7 Tax=Bacteria RepID=Q5WLJ2_BACSK Length = 316 Score = 147 bits (371), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 83/216 (38%), Positives = 118/216 (54%), Gaps = 9/216 (4%) Query: 84 IGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLA 143 +G + +D+DAA K G+ V N P +N +VA+ LL L R +P N K +G W L Sbjct: 76 VGVDNIDVDAAKKHGVTVTNVPNANKHAVADFAFSLLLSLARQIPTGNEKTKKGKWPSLF 135 Query: 144 AGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IENKLPLGNATQVQHLSDLL 201 + + LGIIG G IG ++ A M V YD I+ N + L LL Sbjct: 136 GA--DVYQQTLGIIGLGAIGKEVARRASGFSMTVLAYDPYIDRTYARKNGIEAVSLDALL 193 Query: 202 NMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGA 261 SD V++H+P P T++++G +E+ LMK + L+NASRG +VD AL +AL ++ LAGA Sbjct: 194 QQSDFVTIHIPLLPETRHLIGERELQLMKKSAYLVNASRGGIVDETALYEALQTQQLAGA 253 Query: 262 AIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGST 297 A+DVF EP SPL D+ + PH+ G T Sbjct: 254 ALDVFEEEPL-----HMSPLFSLDSFIAMPHVAGYT 284 >UniRef50_A4RX85 Predicted protein n=8 Tax=cellular organisms RepID=A4RX85_OSTLU Length = 454 Score = 147 bits (370), Expect = 9e-34, Method: Compositional matrix adjust. Identities = 122/407 (29%), Positives = 189/407 (46%), Gaps = 51/407 (12%) Query: 36 EFHKGAL----DDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDL 91 +F KG DD++L D + LRS +V + +V G GTN + + Sbjct: 44 KFPKGKYAVSGDDKELP---GDPMAMMLRSHKLQVSEVPSTVRGIVRCGA---GTNNIPV 97 Query: 92 DAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAH-------RGVWNKLAA 144 ++ GIPVFN P +N +V ELV+ LLL RG+ E N + G + K++ Sbjct: 98 KEMSELGIPVFNTPGANANAVKELVVCSLLLASRGIIEGNKHVNDVINVEENGDYAKISV 157 Query: 145 ---------GSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD------IENKLPLG 189 G E GK LG+IG G IG+++ A LGM V YD +LP Sbjct: 158 RIEKDKAMFGGTEIEGKTLGVIGLGAIGSRVVNAALGLGMNVIGYDPVLSLEAAWRLPGD 217 Query: 190 NATQVQHLSDLLNMSDVVSLHVPE-NPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 ++ L +L ++D +++HVP T +++ AK ++ KPG L+N +RG ++D A Sbjct: 218 KMSRADDLDELFALADYITIHVPYIKGVTHHLIDAKSLAKCKPGVNLLNFARGEIIDGSA 277 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 + + L G + F SDP L ++ PH+G ST+EA+EN Sbjct: 278 VRAGYDAGKLTGKYVSDF-------SDP---DLMGHPRHIVLPHLGASTEEAEENSAAMA 327 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLH---GGRRLMHIHENRPGVLTALNKIFAEQGVNI 365 A ++ + + G+ ++VNFP LP H G RL +++N G L + Q NI Sbjct: 328 ADTMMDFLETGTIRNSVNFPTTILPPHKNSSGARLCIVNKNESGALGEITTFLGTQNCNI 387 Query: 366 AAQYLQTSAQMGYVVIDIEA---DEDVAEKALQAMKAIPGTIRARLL 409 Q + + Y VID+E D + +L A A P I +R + Sbjct: 388 LQQINTSRDSVAYTVIDLETCPEDPGALQDSLAA--ACPMVISSRFI 432 >UniRef50_C5EHH3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EHH3_9FIRM Length = 331 Score = 147 bits (370), Expect = 9e-34, Method: Compositional matrix adjust. Identities = 95/290 (32%), Positives = 150/290 (51%), Gaps = 20/290 (6%) Query: 39 KGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRG 98 KG+ +L I +A + + T +T +++A + L I +G + VD+ A G Sbjct: 33 KGSFSQTELMGMIAEAEVLFSIAGTPVTRPIMDAGKCLKMIASLGVGFDHVDMGHADCLG 92 Query: 99 IPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEAR--GKKLGI 156 +PV N+P + AE + ++ + + A+ RGVW+ G+ + G LGI Sbjct: 93 LPVINSPTQVSDPTAEHTVALIMGIFHNLYRYTAQIKRGVWSTEPFGTTQTSVAGHVLGI 152 Query: 157 IGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQH--------LSDLLNMSDVVS 208 IG G IG +G A +LGM V +YD P+ +T+++ L +++ SD +S Sbjct: 153 IGMGRIGRCVGRKAAALGMDVSYYD-----PVRLSTEIEEKEGFRYGTLEEVIKESDCIS 207 Query: 209 LHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPT 268 LHVP ++M GA +LMK GS +NASRG +VD+ AL DAL + L GAA+DVF T Sbjct: 208 LHVPYTGENRHMFGASAFALMKTGSYFVNASRGALVDLKALADALKTGRLKGAALDVFET 267 Query: 269 EPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDN 318 EP + L + V+LTPH+ T +A+ ++ E + K S+ Sbjct: 268 EPYAGGE-----LEGMEQVILTPHVASETWDARIHMAGECLDGVKKLSEG 312 >UniRef50_C9MSC4 Glycerate dehydrogenase n=3 Tax=Prevotella RepID=C9MSC4_9BACT Length = 316 Score = 147 bits (370), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 92/266 (34%), Positives = 136/266 (51%), Gaps = 11/266 (4%) Query: 45 EQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNA 104 E + E +DA I L ++ ++TE+V+ KL IG G N +D+ AA RG+ V N Sbjct: 36 EDVVERAKDADGI-LINKVNITEEVLQQLPKLKYIGELATGYNNIDIAAARARGVVVCNI 94 Query: 105 PFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSF------EARGKKLGIIG 158 P +T SVA+ V LL V RG W K + E GK LGI+G Sbjct: 95 PAYSTDSVAQHVFALLLNAATRVDHYAEAVRRGEWCKQQDFCYWDTPLIELAGKTLGIVG 154 Query: 159 YGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTK 218 GHIG ++ +A ++GM + Y +N L + L L + SDV++LH P Sbjct: 155 LGHIGQKVAQIAHAMGMDISAYTSKNSTDLPECIRKTTLEGLFSTSDVITLHCPLTAENA 214 Query: 219 NMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFT 278 +M+ A+ + M+PG++LIN RG ++D A+ DAL S HL DV EP + Sbjct: 215 HMINAERLQKMRPGTILINTGRGGLIDEQAVADALESGHLKAYCADVMTDEPPRKDN--- 271 Query: 279 SPLCEFDNVLLTPHIGGSTQEAQENI 304 PL + N +TPH+ +T+EA+E + Sbjct: 272 -PLLQQPNAYITPHVAWATREARERL 296 >UniRef50_D0MDQ9 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MDQ9_RHOM4 Length = 406 Score = 147 bits (370), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 116/350 (33%), Positives = 173/350 (49%), Gaps = 13/350 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIR--DAHFIGLRSRTHLTED 68 ++ LL + + + LE+LR G T ++ L + L E++ + + +RS T +T + Sbjct: 1 MQVLLADKLEDRCLEALRGLGLTV--HNRPELKEAALSEALSALNPEILVVRS-TRVTAE 57 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 ++ AA L I G + +D+ AA+ RGI V N P N +VAEL G +L L R +P Sbjct: 58 MMAAAPALELIIRAGAGYDTIDVGAASDRGIFVANCPGKNAVAVAELTFGLILALDRFIP 117 Query: 129 EANAKAHRGVWNKLAAGSFEA-RGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP 187 E A G WNK A +G+ LG+IG GHIG ++ A + M V + Sbjct: 118 ENVLDAREGRWNKAAYSKGRGLKGRTLGVIGLGHIGREVVRRAHAFEMPVVAWSRSLTDE 177 Query: 188 LGNATQVQHLSDLLNM---SDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 L V + L + +D+V++H+ P T+++ MKPG+ IN SR ++V Sbjct: 178 LARELGVVRKNSPLEVAAEADIVTIHLAAAPETRHLANRAFFEAMKPGAYFINTSRSSLV 237 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL AL + + AA+DV EPA S F PL V T HIG ST++AQE I Sbjct: 238 DEEALAWALEHRGIR-AALDVMEGEPAAKSGSFAHPLAGHPQVYFTHHIGASTKQAQEAI 296 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTAL 354 EV + Y + G + VN E S H L H ++ GVL ++ Sbjct: 297 ADEVVRIIKTYLETGHAPNCVNLEEHSPATH---LLTVRHLDKVGVLASV 343 >UniRef50_Q0AFR7 D-3-phosphoglycerate dehydrogenase n=22 Tax=Bacteria RepID=Q0AFR7_NITEC Length = 405 Score = 146 bits (368), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 114/380 (30%), Positives = 183/380 (48%), Gaps = 32/380 (8%) Query: 46 QLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAP 105 Q+ I D I +RS D+ ++AIG GTN + ++ + RGIPVFN P Sbjct: 31 QISSDISDPDVILVRSHNMHDMDI---PVSVIAIGRAGAGTNNIPVNQMSARGIPVFNTP 87 Query: 106 FSNTRSVAELVIGELLLLLRG-VP-----EANAKAHRGVWNKLAAGS-----FEARGKKL 154 +N +V ELV+ +L+ R +P EA + ++ AG E G+ L Sbjct: 88 GANANAVKELVLAGMLMASRNLIPALRFVEALEGDDQSFHLQVEAGKKQFSGLELPGRTL 147 Query: 155 GIIGYGHIGTQLGILAESLGMYVYFYD----IENKLPLGNATQ-VQHLSDLLNMSDVVSL 209 G+IG G IG + A LGM V YD I++ L Q + DL+ S+ +SL Sbjct: 148 GVIGLGKIGRPVADAAIKLGMKVLGYDPKITIDSAWSLSAEVQRANQIEDLVRRSNFISL 207 Query: 210 HVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTE 269 HVP N ST++++ IS M+ ++L+N SR +VD A+ + S + D FP + Sbjct: 208 HVPLNESTRHLINGPLISHMQKNTILLNFSRNAIVDEDAVLAGIKSGIIKNYVCD-FPDQ 266 Query: 270 PATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPE 329 L + V+ PH+G ST EA+EN + +A +++ Y +G+ VNFP+ Sbjct: 267 K----------LKQQPAVITLPHLGASTHEAEENCAMMIADQIMDYIAHGNISYTVNFPD 316 Query: 330 VSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDV 389 V + R+ + N P +L ++ A+ G+NI ++ +M Y ++D D V Sbjct: 317 VVMERGTPFRVAVANANVPNLLGQISTRMADIGLNIHNMINKSRGEMAYTLVD--TDRAV 374 Query: 390 AEKALQAMKAIPGTIRARLL 409 + + A+ I G + R L Sbjct: 375 PPEIINAIAQITGVLMVRYL 394 >UniRef50_B9KWQ6 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Rhodobacter sphaeroides KD131 RepID=B9KWQ6_RHOSK Length = 349 Score = 146 bits (368), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 94/254 (37%), Positives = 129/254 (50%), Gaps = 26/254 (10%) Query: 63 THLTE---DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGE 119 THL D ++ A +L AIG G VD+ AA RGIPV N P N +VAE + Sbjct: 80 THLAPIIADSMDQAPQLKAIGVSRGGPVNVDMAAARARGIPVVNTPGRNASAVAEFTVAS 139 Query: 120 LLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKL-----GIIGYGHIGTQLGILAESLG 174 LL R + + G W + + + G +L GI+GYG IGT++ L + G Sbjct: 140 LLAETRNLIRGHNDVANGTWGR-SYYHCDHVGPELSELTIGIVGYGDIGTRVARLLQPFG 198 Query: 175 MYVYFYDIENKLPLGNATQVQH--------LSDLLNMSDVVSLHVPENPSTKNMMGAKEI 226 + YD P + T+ + L DL+ DVV+LH P TK M+ I Sbjct: 199 CRIVIYD-----PFKDLTEAEKAAGFEKADLDDLMRRCDVVTLHPRVTPETKGMISRDRI 253 Query: 227 SLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDN 286 +MKPG ++N +RG V+D AL DALAS HL GAA+D F EP P PL + N Sbjct: 254 GMMKPGGYIVNTTRGQVMDYAALYDALASGHLRGAALDTFEFEPP----PADWPLLKLRN 309 Query: 287 VLLTPHIGGSTQEA 300 V L+PHI G+++ + Sbjct: 310 VTLSPHIAGASRHS 323 >UniRef50_Q04DF1 D-3-phosphoglycerate dehydrogenase n=1 Tax=Oenococcus oeni PSU-1 RepID=Q04DF1_OENOB Length = 311 Score = 145 bits (367), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 89/247 (36%), Positives = 136/247 (55%), Gaps = 13/247 (5%) Query: 84 IGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVW-NKL 142 +G + VD A + G+ V P +N +VAE I E+L L + + + + + +G + KL Sbjct: 71 VGFDNVDEKFAGEHGVYVTITPMANASTVAETTIAEILDLSKNLTKISDEMRQGNFAYKL 130 Query: 143 AAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSD--- 199 F+ KK+G++GYG IG Q+ A +LGM V +D P T++ L D Sbjct: 131 DHMGFDLSHKKIGVMGYGRIGRQVAEKANALGMDVLIFD-----PFVKETKIGKLVDRDT 185 Query: 200 LLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLA 259 L++ SDV++LH+ T + G +E+ +MK + LIN RG +VD AL DAL +K + Sbjct: 186 LISQSDVITLHLAVTDQTIHGFGKRELEMMKKSASLINLGRGALVDEQALIDALKTKQIN 245 Query: 260 GAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNG 319 GAA+DVF EP P TS + DNVLLTPHI +T+E E + ++ A ++++ Sbjct: 246 GAALDVFDEEPL----PLTSEFYKLDNVLLTPHIASNTKECMERMAVDSASEVVRVLSGE 301 Query: 320 STLSAVN 326 AVN Sbjct: 302 KPKWAVN 308 >UniRef50_A1HSQ7 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Thermosinus carboxydivorans Nor1 RepID=A1HSQ7_9FIRM Length = 317 Score = 145 bits (367), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 102/278 (36%), Positives = 150/278 (53%), Gaps = 15/278 (5%) Query: 42 LDDEQLKESIR--DAHFIGLRSRTHLTEDVINAA-EKLVAIGCFCIGTNQVDLDAAAKRG 98 L +++L E I+ DA G+ + +T VI A L I +G N +D+ AAA G Sbjct: 37 LTEDELVELIKGMDALVAGMDA---VTAKVIAAGLPTLKIIAKHGVGYNTIDVAAAAAYG 93 Query: 99 IPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIG 158 IPV P +N SVAEL IG +L + R +P+ + RG W+++ GS E GK LGIIG Sbjct: 94 IPVTITPGANNISVAELAIGLMLAVARHIPQMDGIVRRGGWSRMT-GS-ELYGKVLGIIG 151 Query: 159 YGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHL--SDLLNMSDVVSLHVPENPS 216 G IG ++ A + GM + YDI + + V +L +D L +D +SLH P P Sbjct: 152 MGSIGCEVAKRAHAFGMKIIAYDIRPRQDMIENYGVTYLPMADCLAQADFLSLHAPALPE 211 Query: 217 TKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDP 276 T M+ + MK + LIN +RG ++ L DAL + +AGA +D F EP ++ Sbjct: 212 TIGMINKDTLKTMKRTAFLINTARGDLIVEEDLYDALKNGVIAGAGLDTFVHEPIRDARL 271 Query: 277 FTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIK 314 FT DNV+LTPH G +T EA +G+ A ++++ Sbjct: 272 FT-----LDNVVLTPHAGATTHEAVTRMGVMAAEEVVR 304 >UniRef50_C2HP35 Glyoxylate reductase n=10 Tax=Lactobacillus RepID=C2HP35_LACAC Length = 330 Score = 145 bits (367), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 98/327 (29%), Positives = 170/327 (51%), Gaps = 16/327 (4%) Query: 9 DKIKFLLVEGVHQKALESLRAAGYTNIE--FHKGALDDEQLKESIRDAHFIG-LRSRTHL 65 +K K L++ G+ AL+ LR+ + H+ D + + ++I A + G + ++ Sbjct: 11 NKAKVLVLGGLIDDALDDLRSTCEVTVGPVGHRPNDDRQWVLKNI--AKYDGVIVAKMIF 68 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 +++I+AA+ L I + +G + +D+D A ++GI V N P S R AEL + ++ R Sbjct: 69 DKEIIDAAKNLKVISTYGVGFDHIDIDYAREKGIVVTNCPNSVLRPTAELALTMIMASAR 128 Query: 126 GVPEANAKAHRGVW---NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI 182 + + GV+ ++ + + GK LGI+G G IG Q+ A++LGM + +++ Sbjct: 129 RIRYYDHALREGVFLNVDEYDSQGYTIEGKTLGILGMGRIGQQVARFAKALGMKIIYHNR 188 Query: 183 ENKLPLGNA---TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINAS 239 P A + + L+ SD +SLH P T +++ + MK S LIN + Sbjct: 189 HQLKPELEAELNARYVDFASLVKNSDFLSLHAPATDETYHIIDKDVFNNMKDTSFLINVA 248 Query: 240 RGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQE 299 RG++VD L AL +AGAA+DVF EP D L DNV++TPH+G +T + Sbjct: 249 RGSLVDSDDLVAALKEGKIAGAALDVFENEPYPKQD-----LVNMDNVIMTPHVGSATHK 303 Query: 300 AQENIGLEVAGKLIKYSDNGSTLSAVN 326 A+ N+ E A ++ + G +++VN Sbjct: 304 ARYNLTKEAANNILTFFKEGKVINSVN 330 >UniRef50_UPI00016C0F1F D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016C0F1F Length = 387 Score = 145 bits (367), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 111/353 (31%), Positives = 171/353 (48%), Gaps = 29/353 (8%) Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV----- 127 A L+AI GTN + ++ ++GI VFN P +N +V EL + LLL R + Sbjct: 48 APNLLAISRAGAGTNNIPIEKCTEQGIVVFNTPGANANAVKELTLAGLLLASREIIAGTT 107 Query: 128 ------PEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD 181 EA+ A K G E GK L + G G IG + A SLG+ V YD Sbjct: 108 WTQTLAAEADIAAVVEKGKKAFIGP-EISGKTLVVAGLGAIGVLVANAALSLGLKVIGYD 166 Query: 182 ----IENKLPLGNATQ-VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLI 236 + + L + N + V++L + +D ++LHVP STK M +KPG ++ Sbjct: 167 PYLSVTSALLINNGVKIVENLDKAIGQADYLTLHVPYQASTKYMFNQAMFEKIKPGCRIL 226 Query: 237 NASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGS 296 N SRG +VD AL AL +A D FPT + L NV+ PH+G S Sbjct: 227 NFSRGELVDNTALIAALDLGIVAKYVTD-FPT----------AELLNLQNVICIPHLGAS 275 Query: 297 TQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNK 356 T E++EN A +L + G ++VNFP P R+ IH+N P ++ + Sbjct: 276 TPESEENCAEMAATELAAFLKYGVIKNSVNFPTCESPYINKPRITLIHKNIPKMVGQVTN 335 Query: 357 IFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 I A++ +NI ++ ++ Y V+D+++ D A K + ++ IPG ++ RL+ Sbjct: 336 ILADENLNIDNMINKSRGEIAYTVVDLDSLND-APKIISLLEQIPGMVKVRLI 387 >UniRef50_A9BSM0 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=3 Tax=Proteobacteria RepID=A9BSM0_DELAS Length = 354 Score = 145 bits (366), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 82/221 (37%), Positives = 128/221 (57%), Gaps = 12/221 (5%) Query: 84 IGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLA 143 +G + +D+ AA++RGIPV+ P +N +SVAE+ +G + R + +A+ G W++ Sbjct: 103 VGVSNIDVAAASQRGIPVYVTPGANAQSVAEMTLGLMFAAARRIAWMDAELRAGRWSRAQ 162 Query: 144 AGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD-------IENKLPLGNATQVQH 196 G E G+ LG++G+G +G ++ +A +LGM V +D + + Sbjct: 163 DG-LELSGRTLGLLGFGQVGQRVARVALALGMQVVAFDPAFDPACAPGPGAVAGVRMLGS 221 Query: 197 LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASK 256 + +LL +SDV+SLH+P N T++++ A I+ + G+LL+N +RG VVD AL DAL S Sbjct: 222 VDELLPLSDVLSLHLPLNARTRHLLDAGRIAQLPRGALLVNTARGEVVDEAALIDALRSG 281 Query: 257 HLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGST 297 HLA A +D EP P L DNV+LTPH+GGST Sbjct: 282 HLAAAGLDTMAEEPL----PAGHALAALDNVVLTPHVGGST 318 >UniRef50_Q03W66 D-3-phosphoglycerate dehydrogenase n=3 Tax=Leuconostoc RepID=Q03W66_LEUMM Length = 392 Score = 145 bits (366), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 115/369 (31%), Positives = 181/369 (49%), Gaps = 39/369 (10%) Query: 59 LRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIG 118 LRS+ E + + +V G G N + ++ +KRGI +FN P N +V EL I Sbjct: 36 LRSQNLHDEPIDDNVRAIVRAGA---GFNNIPVEELSKRGIAIFNTPGGNANAVKELTIA 92 Query: 119 ELLLLLRGVPEANAKAH---------RGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGIL 169 L+L R V A A+ R NK E GKKLG+IG G++G+++ Sbjct: 93 SLVLAARPVVGAIQFANDTRGGDVSLRTESNKGGYRGTELAGKKLGVIGLGNVGSKVANT 152 Query: 170 AESLGMYVYFYDIENKLPLGNAT----------QVQHLSDLLNMSDVVSLHVPENPSTKN 219 A +L M V YD P NA + + ++L +D V++H+P + Sbjct: 153 ALALDMDVIGYD-----PGLNANTAWRVDRHIVHARSVEEVLEQADYVTVHIPLEEKNRY 207 Query: 220 MMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTS 279 + A ++ LMKP + L+N SRG +VD A +AL + L V+ T+ A +S F + Sbjct: 208 FIDADKLHLMKPTAALLNLSRGGIVDDEAAKEALDNDQLR-----VYITDFA-DSVLFDN 261 Query: 280 PLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRR 339 P V++TPHIGGST EA++ L A +L +Y G+ +++VN+P+++ P R Sbjct: 262 P-----KVIITPHIGGSTIEAEDTSALMAARQLDEYLTTGNIVNSVNYPDINEPFTTKYR 316 Query: 340 LMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDI-EADEDVAEKALQAMK 398 + IHEN P +L ++K F + +NI + Y ++ I + E+ E A+ Sbjct: 317 VGIIHENVPNMLGQISKFFGDHNINIEQLSNRAVGNYAYTMVAINDFTEEQQELVKTALD 376 Query: 399 AIPGTIRAR 407 IP I R Sbjct: 377 EIPHVILTR 385 >UniRef50_Q4PK14 Predicted D-isomer specific 2-hydroxyacid dehydrogenase family protein n=1 Tax=uncultured bacterium MedeBAC49C08 RepID=Q4PK14_9BACT Length = 395 Score = 145 bits (366), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 120/417 (28%), Positives = 199/417 (47%), Gaps = 50/417 (11%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K + + K L+ L+ GY A+ +E ES DA I LRS ++ + Sbjct: 4 KVKTINNISDKGLDILKNKGY--------AVGEE---ESEPDA--IILRSHKLQMSEIPS 50 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG----- 126 + + +V G G N + ++ +K GIPVFN P +N +V E+V+ LL+ RG Sbjct: 51 SVKAIVRAGA---GVNNIPVEECSKIGIPVFNTPGANANAVKEMVLAALLMSSRGIFDGV 107 Query: 127 --------VPEANAKAHRGVWNKLAAGSFEARGKK---LGIIGYGHIGTQLGILAESLGM 175 V + N KAH K SF+ R K LG++G G IG ++ + LGM Sbjct: 108 KFVHGIEDVSKENLKAHIESGKK----SFKGRELKDGCLGVVGMGAIGAKVAEMGVMLGM 163 Query: 176 YVYFYD----IENKLPLGNATQVQH-LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMK 230 V +D +E L N + + + ++ SD V+LHVP N T M+ + Sbjct: 164 RVIGFDPQITVEAAWALPNEVERKETIEEIFKESDYVTLHVPANEHTTGMINKDLLLHSN 223 Query: 231 PGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLT 290 G LIN +R +V+ A+ DAL + L D P ++++L Sbjct: 224 KGLRLINFARDEIVNSQAIIDALENDKLNKYVTDFADL-------PLIERSKSNEDIVLL 276 Query: 291 PHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGV 350 PHIG ST +A+EN + A ++I + ++G+ ++VN+P++ P+ RL ++N G+ Sbjct: 277 PHIGASTMQAEENCSVMAANQIINFLEHGNIKNSVNYPQIIEPMETSYRLTIANKNVSGM 336 Query: 351 LTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRAR 407 + + I AE+G+NI ++ + Y VID+ D + + K+++A+K I R Sbjct: 337 IGKITAIIAEEGLNIIDMKNRSRDDIAYNVIDL--DSEPSTKSIEAIKGEENIINVR 391 >UniRef50_B0K2Z0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=3 Tax=Thermoanaerobacter RepID=B0K2Z0_THEPX Length = 324 Score = 145 bits (366), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 95/269 (35%), Positives = 143/269 (53%), Gaps = 8/269 (2%) Query: 51 IRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTR 110 ++D I LR+R+ +T +VI A L I G + +D++AA ++GI V N P N Sbjct: 39 VKDVDAIILRTRSKITREVIENAPHLKIISRTGAGVDNIDVNAATEKGILVCNLPAVNNL 98 Query: 111 SVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAG-SFEARGKKLGIIGYGHIGTQLGIL 169 SVAE I +L L + + + G W + S E GK LGI+G G+IG+ + Sbjct: 99 SVAEHTIAMILNLSKQLSLMDKAVRSGNWGARNSNISVEIEGKVLGIVGMGNIGSLVAKK 158 Query: 170 A-ESLGMYVYFYD--IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEI 226 + LGM + YD ++ K + V +L SD V+LH P+ P T+ M+ + I Sbjct: 159 CHDGLGMKIVAYDPYVKEKFRGYDYKFVDTREELFKESDFVTLHCPDIPETRGMITRELI 218 Query: 227 SLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDN 286 MK + LINA+RGTV+D AL +AL K +AGA +DVF EP ++ + L +N Sbjct: 219 YSMKHTAYLINAARGTVIDEQALIEALKEKRIAGAGLDVFQQEPPSSDN----ELLRLEN 274 Query: 287 VLLTPHIGGSTQEAQENIGLEVAGKLIKY 315 V+L+PH T+EA + +E +I Y Sbjct: 275 VILSPHSAALTKEATVRMAVEAVQAVIDY 303 >UniRef50_Q2RH37 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=6 Tax=Bacteria RepID=Q2RH37_MOOTA Length = 329 Score = 145 bits (366), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 112/326 (34%), Positives = 155/326 (47%), Gaps = 17/326 (5%) Query: 19 VHQKALESLRAAGYTNIEFH--KGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKL 76 V Q AL+ L A Y ++E + L +L E +R I L ++V AA+ Sbjct: 12 VPQPALDLL--AEYCDLEINPEDRVLTRAELLEKVRGRDGILCLLTDILDDEVFTAAKGA 69 Query: 77 VAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN----A 132 +G N VDL+AA + GI + N P T + A++ L + R V E + A Sbjct: 70 KIFANLAVGFNNVDLEAATRHGIMITNTPGVLTEATADMAWALLFAVARRVVEGDKFTRA 129 Query: 133 KAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNAT 192 ++G W L E GK LG+IG G IGT A M V ++D++ AT Sbjct: 130 GKYKG-WGPLLMLGQEITGKTLGVIGAGRIGTAFARKARGFDMKVLYHDVQPSKAFEEAT 188 Query: 193 QVQHLSD--LLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 Q + LL +D VSLHVP PST +++ E+ LMK ++LIN SRG VVD AL Sbjct: 189 GGQFVDKETLLKEADFVSLHVPLMPSTTHLISTPELKLMKKTAILINTSRGPVVDEKALV 248 Query: 251 DALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAG 310 AL K + GA +DVF EP L + +NV+L PHI +T E + N+ L A Sbjct: 249 KALREKEIWGAGLDVFENEPE-----LAPGLADLENVVLCPHIASATWETRTNMALMAAN 303 Query: 311 KLIKYSDNGSTLSAVNFPEVSLPLHG 336 L+ +N PEV HG Sbjct: 304 NLLAALRGELPPQCLN-PEVYYRQHG 328 >UniRef50_A8MCX1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=6 Tax=Thermoproteaceae RepID=A8MCX1_CALMQ Length = 317 Score = 145 bits (365), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 88/269 (32%), Positives = 144/269 (53%), Gaps = 6/269 (2%) Query: 38 HKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKR 97 +K + E+L + + + + +RSRT +T +VI+ L I +G + +D+D A KR Sbjct: 34 YKPGIQHEELLKIVENYDILVVRSRTKVTREVIDRGASLKIIARAGVGLDNIDVDYALKR 93 Query: 98 GIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGII 157 G+ + N+P + T S AEL + +L++ R + G W+K E RGK LG++ Sbjct: 94 GLTIVNSPNAATYSAAELTLSLMLIISRNLHLHLIDVKNGKWSKGLYHGIELRGKTLGVV 153 Query: 158 GYGHIGTQLGILAESLGMYVYFYDIEN--KLPLGNATQVQHLSDLLNMSDVVSLHVPENP 215 G+G IG + A++LGM + D+ + + V L++LL+ SDVV+LHV N Sbjct: 154 GFGRIGRAVANYAKALGMRILATDVVDISRYAEELGASVVSLTELLSRSDVVTLHVALNK 213 Query: 216 STKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSD 275 T +M+ + L+K ++++N SRG V+D AL + L L G +DV EP + Sbjct: 214 ETYHMLNDDRLKLIKDNAIIVNTSRGEVIDTKALLNHL--DRLWGVGLDVLEHEPP--RE 269 Query: 276 PFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 + L + V++TPHIG T +AQ I Sbjct: 270 DWEIKLIQHPKVVVTPHIGAETIDAQGRI 298 >UniRef50_C9RL30 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RL30_FIBSS Length = 388 Score = 144 bits (364), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 109/383 (28%), Positives = 194/383 (50%), Gaps = 36/383 (9%) Query: 46 QLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAP 105 Q+ +SI + I +RS T++ + L+A+ G N + +D A+ +GI VFN P Sbjct: 23 QVSDSIENPDAILVRSAQVDTDNF----DGLLAVARAGAGVNNITIDKASAKGICVFNTP 78 Query: 106 FSNTRSVAELVIGELLLLLRGVPEANAK-----------AHRGVWNKLAAGSFEARGKKL 154 +N +VAELV+ L + +R +A A A K E GK L Sbjct: 79 GANANAVAELVMTVLGMAVRNADKAAAWVKGLDVNDPDLAKTVESGKKKFAGMELAGKTL 138 Query: 155 GIIGYGHIGTQLGILAESLGMYVYFYD----IENKLPLGNATQVQHLSDLLNMSDVVSLH 210 G++G G IG + A M V Y+ N L N ++ L ++ SD +++H Sbjct: 139 GVVGLGKIGVLVANYARWKNMRVIAYEPYPNANNMHELSNKVEIADLDTVIANSDFLTVH 198 Query: 211 VPE-NPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTE 269 VP T+N++ K ++ K GS ++N +RG +V++ + + LAS L G D FPT Sbjct: 199 VPFIKGVTENLLNRKNLAQFK-GSYIMNFARGGIVEMDPVNEMLASGSLQGYLCD-FPT- 255 Query: 270 PATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPE 329 + L + D V PH+G ST+EA+EN + +L Y + G ++VNFP Sbjct: 256 ---------AELIKNDKVTCFPHLGASTEEAEENCAVMAVEELKDYIEYGCVRNSVNFPA 306 Query: 330 VSLPLHGG--RRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADE 387 + H G R++ I+++ P +++ + K+F +G+NIA+ +++ ++GY ++D+E+ Sbjct: 307 LVDHPHAGIKSRVVVINQDVPNMISEITKVFGAEGINIASFSNKSNGKIGYNLVDVESKV 366 Query: 388 DVAEKALQAMKAIPGTIRARLLY 410 D + ++ + + I+ R+++ Sbjct: 367 D--DSIVEKLSKLDKVIKVRVIH 387 >UniRef50_Q30V14 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=2 Tax=Desulfovibrio RepID=Q30V14_DESDG Length = 305 Score = 144 bits (364), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 93/249 (37%), Positives = 131/249 (52%), Gaps = 11/249 (4%) Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 LT V++A L I G + VD++AA RGI V N P T++VAEL +G L L+ Sbjct: 59 LTARVMDALPGLKVISRCGTGMDNVDMEAARARGIAVRNTPDGPTQAVAELTLGLALDLM 118 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 R V + + GVW K GK+LGI+G G IG + + LG+ V F D Sbjct: 119 RQVSRMDRELRSGVWKKRMGNLLG--GKRLGIVGMGRIGRAVADIFTPLGVQVAFND--- 173 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + + +LL +D++SLH ++ A+ + MK GS +IN +RG ++ Sbjct: 174 PVSCCGDYPCMPVEELLGWADILSLHCSMTGGECSLFTAEHLRRMKRGSWVINVARGGLI 233 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL +ALA HLAGAA+DVF E P+T PL DNV+LTPHIG +EA+ + Sbjct: 234 DEQALYEALADGHLAGAAVDVFGNE------PYTGPLSSLDNVILTPHIGSYAKEARIRM 287 Query: 305 GLEVAGKLI 313 + LI Sbjct: 288 ETDTIANLI 296 >UniRef50_A0Q365 D-isomer specific 2-hydroxyacid dehydrogenases n=11 Tax=Bacteria RepID=A0Q365_CLONN Length = 317 Score = 144 bits (364), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 100/271 (36%), Positives = 144/271 (53%), Gaps = 6/271 (2%) Query: 31 GYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVD 90 G+ I F D + L E +DA + L + L +VI + +KL I G + VD Sbjct: 27 GHEVILFEDKVQDKKVLMERAKDAEVLVL-ANMPLEGEVIKSDDKLKMISVAFTGIDHVD 85 Query: 91 LDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEAR 150 A ++ + V NA +T SVAEL G + +LR + + KA R + E Sbjct: 86 TKACTEKQVMVCNAAGYSTSSVAELTYGLIFSVLRNIVPLD-KATREGKTRNGFSQNEIL 144 Query: 151 GKKLGIIGYGHIGTQLGILAESLGMYVYFYD-IENKLPLGNATQVQHLSDLLNMSDVVSL 209 GK +GI+G G IG ++G +A++ G V Y E K + + L +LL+ SD+VSL Sbjct: 145 GKTIGIVGTGAIGIRVGQIAKAFGCNVLAYSRSERKEAIDTGFKYVSLDELLSKSDIVSL 204 Query: 210 HVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTE 269 HVP N TK ++ ++I LMK S+LIN +RG VVD AL +AL + GA IDVF E Sbjct: 205 HVPLNDETKGLISKEKIELMKSSSILINTARGPVVDNSALAEALKKGKIKGAGIDVFEIE 264 Query: 270 PATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 P + + PL NV++TPHI +T+EA Sbjct: 265 PPISKE---HPLFNAPNVVVTPHIAFATEEA 292 >UniRef50_B0KD78 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=8 Tax=Bacteria RepID=B0KD78_THEP3 Length = 332 Score = 144 bits (363), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 94/271 (34%), Positives = 142/271 (52%), Gaps = 12/271 (4%) Query: 44 DEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFN 103 +E+L + +DA + + +T VI A +K I + IG + +D+ AA RGI V N Sbjct: 38 EEELILACKDADGL-INQYAKITRRVIEALDKCKVIARYGIGVDTIDIKAATARGICVVN 96 Query: 104 APFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHI 162 P V++ + LL R V N G W+ K++ + RGK LG++G+G I Sbjct: 97 VPDYCMDEVSDHALALLLGCARKVVLMNNAVKAGTWDFKISKPIYRLRGKVLGLVGFGRI 156 Query: 163 GTQLGILAESLGMYVYFYD----IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTK 218 L A G + YD E+ P G AT V L +L++ SD VS+H P T Sbjct: 157 PRTLAEKARPFGFDILVYDPYITQEDVEPYG-ATLV-GLEELMSKSDFVSVHAPLTEKTY 214 Query: 219 NMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFT 278 +++G EI LMKP + +IN +RG V+D AL AL K +AGA +DV EP P Sbjct: 215 HLIGETEIGLMKPSAFIINTARGPVIDEKALIKALQEKRIAGAGLDVLEQEPT----PSD 270 Query: 279 SPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 +PL + DNV++TPH+ ++E++ + + A Sbjct: 271 NPLLKMDNVIITPHVAWYSEESEAELRTKAA 301 >UniRef50_A0LN07 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=2 Tax=Bacteria RepID=A0LN07_SYNFM Length = 317 Score = 144 bits (363), Expect = 6e-33, Method: Compositional matrix adjust. Identities = 97/303 (32%), Positives = 152/303 (50%), Gaps = 15/303 (4%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K K LL E +H + E L + +LD++ L D I +R+ +T + Sbjct: 4 KFKILLYESMHARGTEVLAEKCEL---VYATSLDEKNLIAQAADVDGIIIRANGAVTRAL 60 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I +A +L IG +G + +DL A +RG+ V P +NT SVAE +G ++L + + Sbjct: 61 IESAPRLKVIGRHGVGLDAIDLRCAKERGVKVVFTPTANTESVAEHFVGMAIMLAKMIRT 120 Query: 130 ANAKAHRGVW---NKLAAGSFEARGKKLGIIGYGHIGTQLG-ILAESLGMYVYFYDIENK 185 + G W N+L E GK LG++G+G IG Q I M V +YD+ + Sbjct: 121 GDIALRTGDWAARNRLIGT--ELHGKALGVLGFGRIGRQTARICRNGFAMNVIYYDVCDY 178 Query: 186 LPLGNATQVQHLS--DLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 + Q + +S ++ SD +S+++P PST++ + AK I LMKP + LIN +RG V Sbjct: 179 PAVEKELQAKRVSGEEVFEQSDFISVNLPLLPSTRHFVNAKLIRLMKPTAFLINMARGPV 238 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 + + AL K +AG DV+ EP P PL + DN + TPH+ ++EA Sbjct: 239 WNEEDVAGALREKRIAGVGSDVYEVEPV----PADHPLLKMDNFVGTPHMSAHSEEAMIR 294 Query: 304 IGL 306 + L Sbjct: 295 MSL 297 >UniRef50_C4DLZ3 Lactate dehydrogenase-like oxidoreductase n=1 Tax=Stackebrandtia nassauensis DSM 44728 RepID=C4DLZ3_9ACTO Length = 324 Score = 144 bits (362), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 97/268 (36%), Positives = 143/268 (53%), Gaps = 9/268 (3%) Query: 64 HLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLL 123 + +VI AA++L G +G + +D+ AA +RGI V P N +SVAE LL + Sbjct: 61 RFSAEVIAAADRLKVFGRTGVGYDNIDVAAATERGIAVCPTPGVNRQSVAEHTFALLLSV 120 Query: 124 LRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD-- 181 RGVP G W +++ E G LG+IG G IG + +A GM V +D Sbjct: 121 ARGVPGNVTAVAAGDWPQVS--GRELSGATLGLIGLGAIGKAVARIALGFGMRVIAHDPY 178 Query: 182 IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 ++ + + + L +LL +D VSLH+ + +T++++ A+ I+ MKPG+ L+N SRG Sbjct: 179 LDAEAVAASGVERASLDELLATADFVSLHIFLDDATRHLIDAEAIATMKPGAYLVNTSRG 238 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 VVD AL AL L+GA +DV TEP P SPL DN+++T HIG +T E++ Sbjct: 239 GVVDETALAAALREGRLSGAGLDVLETEPL----PPDSPLRGLDNLIITAHIGAATVESR 294 Query: 302 ENIGLEVAGKLIKYSDNGSTLSAVNFPE 329 G A +I D + VN PE Sbjct: 295 ARSGRMAAQAVIDVLDGRTPEHVVN-PE 321 >UniRef50_A7VWU5 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753 RepID=A7VWU5_9CLOT Length = 321 Score = 144 bits (362), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 97/294 (32%), Positives = 145/294 (49%), Gaps = 18/294 (6%) Query: 21 QKALESLRAAGYTNIEFH-KGALDDEQLKESIRD--AHFIGLRSRTHLTEDVINAAEKLV 77 + A E L G+ IE+ + +++K +D IG E++ A L Sbjct: 17 KSAKELLEKEGFEVIEYQGDTVMTADEIKAVGKDICGAIIGC---DEWNEEIFQACPNLK 73 Query: 78 AIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRG 137 AIG F +G N +DL+AA + G+ V A N SVAE I +L LR + + RG Sbjct: 74 AIGRFGVGYNNIDLEAAKRHGVKVSIATGINADSVAENTILLVLASLRDLVNLDNAVRRG 133 Query: 138 VWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLG-----MYVYFYDIENKLPLGNAT 192 W + + G R K G++G+G I + L ++ G Y + + E LG Sbjct: 134 EWVRDSTGRI-IRNKVYGLVGFGAIARYVAKLVKAFGPARIIAYDKYPNYEEAEKLG--V 190 Query: 193 QVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDA 252 ++ ++ SD++S+HVP P T M G KE MK ++ +N +RG+VVD A+ A Sbjct: 191 EIVDFDTVVKESDIISVHVPATPETYKMFGEKEFKAMKDSAVFVNVARGSVVDEAAMYKA 250 Query: 253 LASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 L K +A AA DVF EP P +PL E DN+++ PH+ G T E E +GL Sbjct: 251 LKEKWIARAATDVFEEEPT----PKDNPLFELDNIVMMPHMCGDTWETFEAVGL 300 >UniRef50_B0NG91 Putative uncharacterized protein n=1 Tax=Clostridium scindens ATCC 35704 RepID=B0NG91_EUBSP Length = 319 Score = 144 bits (362), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 97/287 (33%), Positives = 148/287 (51%), Gaps = 14/287 (4%) Query: 44 DEQLKESIR--DAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPV 101 DEQ+KE I DA GL ++++I+ A KL I + +G ++VD++AA ++GI V Sbjct: 42 DEQIKEEIAAADAVIAGL---DEYSKELIDLAGKLKVISRYGVGYDKVDVEAADRKGILV 98 Query: 102 FNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGH 161 P +N SVA+L + +L R V +A A +G G E K LG+IG G Sbjct: 99 TITPGANGDSVADLAVTLMLDAARNVAAMDA-AMKGRAQARPQG-VEMWQKTLGVIGTGR 156 Query: 162 IGTQLGILAESLGMYVYFYDIENKLPLGNATQVQH--LSDLLNMSDVVSLHVPENPSTKN 219 IG + + M + YDI ++ LS LL SD +++H P P TK+ Sbjct: 157 IGQGVARRCKGFDMKILCYDIYENEAFKKECNAKYVDLSTLLRESDFITIHSPLTPETKD 216 Query: 220 MMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTS 279 M+GA+E +MK ++++N +RG +++ AL +AL S + GA +D EP P+ S Sbjct: 217 MIGAREFDMMKNDAVIVNTARGGIINEEALYEALKSGSIRGAGLDATVDEP-----PYDS 271 Query: 280 PLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVN 326 PL N +LTPH G +T+EA + L A ++ G VN Sbjct: 272 PLMTLPNCILTPHAGAATKEASSKMSLMAAQNVVDVLTTGDCKYKVN 318 >UniRef50_D1RHC1 D-3-phosphoglycerate dehydrogenase n=1 Tax=Legionella longbeachae D-4968 RepID=D1RHC1_LEGLO Length = 399 Score = 144 bits (362), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 102/357 (28%), Positives = 177/357 (49%), Gaps = 35/357 (9%) Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV----- 127 ++ L A+ GT+ + ++ K+GIPVF AP +NT ++ ELV+ +++ R + Sbjct: 48 SKNLKAVARAGTGTDNIPVEELTKKGIPVFYAPGANTNAIKELVMAAMIMGYRHLDQTRT 107 Query: 128 ------PEANAKAHRGVWNKLAAG-SFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 E N H+ + K E GK LG+IG G++G ++ A +LGM V + Sbjct: 108 FITNLTKENNQLFHQEIETKKKKFIGHEISGKILGVIGLGNVGVKVANAAFALGMKVLGF 167 Query: 181 DIENKLPLGNA-------TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGS 233 D + L NA +V ++ LL +D+++LH+P N TK+++ + I L+KP + Sbjct: 168 D--TNMTLNNALALMPGVEKVTDMNLLLTHADIITLHIPLNVETKHLINEQNIVLLKPNT 225 Query: 234 LLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHI 293 LL+N SR VV PA+ L + L G D FP T L NVL PH+ Sbjct: 226 LLLNFSREQVVSEPAILQQLNNNQLMGYITD-FP----------TINLANHPNVLCFPHL 274 Query: 294 GGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLP---LHGGRRLMHIHENRPGV 350 G STQEA+++ + + Y ++G +VNFP +SL + R++ I++N PGV Sbjct: 275 GASTQEAEQSASEMIIRNICNYLEHGGIEYSVNFPNISLSTAQIPNCHRMLTINQNTPGV 334 Query: 351 LTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRAR 407 + + + ++ N+ ++ + +ID+ ++ + + +K I + R Sbjct: 335 IGKITQKISKLKYNVEQMENKSRGPIAINLIDLSGPKESLPELCKQLKEISSLMHVR 391 >UniRef50_Q46AE6 Glycerate dehydrogenase n=2 Tax=Methanosarcina RepID=Q46AE6_METBF Length = 323 Score = 144 bits (362), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 96/262 (36%), Positives = 138/262 (52%), Gaps = 11/262 (4%) Query: 45 EQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNA 104 E+ +RDA + L R + NA+ L + + G + +DL AA ++G+ V N Sbjct: 36 EEFISRVRDADIV-LVGRYGFSGKAFNASRNLQMLSVWQTGYDHIDLKAATEKGVIVSNV 94 Query: 105 PFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGT 164 P SVAE+V L LLR V A+ + G ++ + GK +G+IG G IG+ Sbjct: 95 PDYAFDSVAEMVFALALNLLRKVHVADIRLREGNFDWRHYFGSQIMGKTMGVIGTGSIGS 154 Query: 165 QLGILAESLGMYVYFY----DIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNM 220 ++ +A M V E LG + L LL +D+V+LHVP PST+ M Sbjct: 155 RVIQIAHGFNMNVISVTGHPSEEKARSLG--VKFVDLDTLLAEADIVTLHVPLTPSTEKM 212 Query: 221 MGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSP 280 +GAKE++ MK ++LIN +RG VVD AL +AL K + GA +DVF EP P P Sbjct: 213 IGAKELAKMKKSAILINTARGKVVDEAALIEALKEKKIRGAGLDVFEKEPL----PANDP 268 Query: 281 LCEFDNVLLTPHIGGSTQEAQE 302 L +NV+LTPHI T+E+ E Sbjct: 269 LKALENVVLTPHIAFLTEESLE 290 >UniRef50_A4WXD4 Dimethylmenaquinone methyltransferase n=2 Tax=Alphaproteobacteria RepID=A4WXD4_RHOS5 Length = 334 Score = 143 bits (361), Expect = 9e-33, Method: Compositional matrix adjust. Identities = 87/252 (34%), Positives = 138/252 (54%), Gaps = 7/252 (2%) Query: 64 HLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLL 123 +T++VI A+ L I +G + +DL AA RGIPV + SN+R+VAE I L+L Sbjct: 66 RITDEVIGASPGLKVIVKHGVGVDNIDLAAAEARGIPVLRSMGSNSRAVAEHAIALALML 125 Query: 124 LRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD-- 181 ++ + NA G W K + +G LG++GYG IG + +AE+LGM V +D Sbjct: 126 VKEIQPLNAAVKGGAWPKPTFIGKDFQGAMLGLVGYGGIGRETARMAEALGMEVVVHDPY 185 Query: 182 IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 L +L D++SLH P +T++++ A+ +++MK ++++N +RG Sbjct: 186 APEAAEADGFAAAADLEAMLPALDILSLHCPLTSATRDLIDARRLAMMKRTAVIVNTARG 245 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 ++D AL DAL + +AGAA+D F TEP + PL E ++ TPHIGG T + Sbjct: 246 GIIDEAALADALRAGAIAGAALDSFATEPPAADN----PLWELPTLVATPHIGGVTAGSS 301 Query: 302 ENIGLEVAGKLI 313 + E+A + I Sbjct: 302 RAMA-EIAARHI 312 >UniRef50_C2HJZ3 Possible glyoxylate reductase n=2 Tax=Finegoldia magna RepID=C2HJZ3_PEPMA Length = 313 Score = 143 bits (361), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 100/293 (34%), Positives = 156/293 (53%), Gaps = 15/293 (5%) Query: 17 EGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKL 76 E + +K E+ + +++F L E+LK I+D + + ++I+AA+ L Sbjct: 11 EEIIKKYEENFEVDYHDSLDF----LSKEELKTRIKDVEGLVCPLSEKIDSEIIDAAKNL 66 Query: 77 VAIGCFCIGTNQVDLDAAAKRGIPVFNAPFS-NTRSVAELVIGELLLLLRGVPEANAKAH 135 I + G + VD+D A ++GI V NAP S +T+S AEL G ++ LLR + + N+ + Sbjct: 67 KIIANYGAGFDNVDIDYAKEKGIIVTNAPASASTKSTAELTFGLMIDLLRNITKMNSDCY 126 Query: 136 RGV---WNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNAT 192 W + GK LGIIG G IGT++ A++ M V FY+ +K + A Sbjct: 127 DNSFEGWKPVYGLGETLEGKTLGIIGLGRIGTEVMRKAKAFDMNVIFYN-RSKKEVDGAK 185 Query: 193 QVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDA 252 QV L+ LL SDV++LH + +++ AK S MK + LINASRG V+ L +A Sbjct: 186 QVD-LNYLLENSDVITLHTAYSEKLHHLIDAKAFSKMKKSAYLINASRGKVISEQDLINA 244 Query: 253 LASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 L +AG A+DV+ EP + D L N+LL PH+G +T+ A+ +G Sbjct: 245 LNDGEIAGCALDVYEFEPKISED-----LRNAKNILLAPHLGNATKLARVQMG 292 >UniRef50_Q6AMI7 Related to D-3-phosphoglycerate dehydrogenase n=1 Tax=Desulfotalea psychrophila RepID=Q6AMI7_DESPS Length = 393 Score = 143 bits (360), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 119/391 (30%), Positives = 192/391 (49%), Gaps = 54/391 (13%) Query: 47 LKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPF 106 + E D I LRS +D L+A+ GTN V+++ A K+GI VFN P Sbjct: 26 VNEDENDPQGIILRSSPVDVDDY----PSLLAVARAGAGTNNVNVERATKKGICVFNTPG 81 Query: 107 SNTRSVAELVIGELLLLLRG---------------------VPEANAKAHRGVWNKLAAG 145 +N +V +LV L + R V EA A++G Sbjct: 82 ANANAVVDLVFPMLGVWKRNIFNGINFCKSLTAVDPDKVDSVVEAQKSAYKGE------- 134 Query: 146 SFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD----IENKLPLGNATQV-QHLSDL 200 E GK L ++G G IG +L M V +D +EN L +V + L D Sbjct: 135 --EIAGKNLTVVGLGQIGVRLANGGIQRLMNVKGFDPAPALENIHQLSPQVRVCRALKDA 192 Query: 201 LNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAG 260 ++ +DV+SLH+P N T+N++ A+ ++ +K G++LIN SR +VD A+ DAL S L G Sbjct: 193 VSDADVISLHLPLNDRTRNLVNAEFLAKVKRGAILINYSRAPIVDEQAVLDALDSGQL-G 251 Query: 261 AAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGS 320 A + FP T+ + +L TPH+G ST +++ N +L Y G+ Sbjct: 252 AFLSDFP----------TAKTIGHEKILTTPHLGASTSQSEGNCSTMAVKELSSYLKYGN 301 Query: 321 TLSAVNFPEV-SLPLHGGR-RLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGY 378 + +VNFP + S P + RL+ I+++ PG++ ++ IF+ VNI + Q++ +GY Sbjct: 302 VVHSVNFPNIESTPADTVKNRLIVINKDVPGMIANVSNIFSGFNVNIVSYLNQSNGAIGY 361 Query: 379 VVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 +ID+E E + E+ + + +P IR R++ Sbjct: 362 NIIDME--ETIPEELVAKIVELPDVIRTRVI 390 >UniRef50_B6YWH0 Glyoxylate reductase n=95 Tax=cellular organisms RepID=GYAR_THEON Length = 334 Score = 143 bits (360), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 97/329 (29%), Positives = 158/329 (48%), Gaps = 20/329 (6%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K K L+ + + ++ LR + + + E L E +RD + + +V Sbjct: 2 KPKVLITRKIPENGIKMLREHFEVEVWEDEHEISREVLLEKVRDVDALVTMLSERIDAEV 61 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 +AA +L + + +G + +D++ A K G+ + N P T + A++ LL R + E Sbjct: 62 FDAAPRLKIVANYAVGYDNIDIEEATKMGVYITNTPDVLTNATADMAWVLLLATARRLIE 121 Query: 130 ANAKAHRGVWNKLAAG-------SFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI 182 A+ G W K ++ G+ +GI+G+G IG + A+ GM + Y+ Sbjct: 122 ADKFVRSGEWKKRGVAWHPLMFLGYDVYGRTIGIVGFGRIGQAIARRAKGFGMRI-LYNS 180 Query: 183 ENKLP-----LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLIN 237 + P LG + L +LL SD V L VP T +M+ + + LMKP ++L+N Sbjct: 181 RTRKPEVEKELG--AEFMPLDELLKESDFVVLVVPLTKETYHMINEERLKLMKPTAILVN 238 Query: 238 ASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGST 297 +RG VVD AL AL +AGA +DVF EP + + F+ DNV+L PHIG +T Sbjct: 239 IARGKVVDTEALVKALREGWIAGAGLDVFEEEPYYHEELFS-----LDNVVLAPHIGSAT 293 Query: 298 QEAQENIGLEVAGKLIKYSDNGSTLSAVN 326 A+E + VA LI + + + VN Sbjct: 294 YGAREGMAELVARNLIAFKNGEVPPTLVN 322 >UniRef50_UPI0001C42ACE D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein n=1 Tax=Bacillus pseudofirmus OF4 RepID=UPI0001C42ACE Length = 314 Score = 142 bits (359), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 94/268 (35%), Positives = 140/268 (52%), Gaps = 12/268 (4%) Query: 34 NIEFHKGALDDEQLKESIRDAHFI-GLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLD 92 N+E + ++L IR+A I +R RTH T ++ L+ I GT +D Sbjct: 28 NVEIFYDQAEGDELVNRIRNAEIIIPIRERTHFTRELFLQLPNLMLIAQTGSGTAHIDKG 87 Query: 93 AAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGK 152 AA ++ I + P +++V ELV G ++ R + + N + + W+ A G+ A GK Sbjct: 88 AAEEQEIEILTTP-GGSQAVTELVFGLMIAHARQILQLNQETKQNKWSN-AMGTGLA-GK 144 Query: 153 KLGIIGYGHIGTQLGILAESLGMYVYFYD---IENKLPLGNATQVQHLSDLLNMSDVVSL 209 LG++G G IG ++ +A+ GM V + E + L + V+ L L + SD +S+ Sbjct: 145 TLGVVGLGKIGARVAGIAKVFGMRVIAWGPRLTEERAFLHDVEYVE-LEQLFSQSDFLSV 203 Query: 210 HVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTE 269 HV P TKN++ A+ +MK + +N SRG +VD AL AL K +AGA IDVF E Sbjct: 204 HVRLVPETKNLIKAEHFKMMKRSAFFMNTSRGEIVDEEALVQALEEKQIAGAGIDVFTQE 263 Query: 270 PATNSDPFTSPLCEFDNVLLTPHIGGST 297 P PL E DNV+LTPHIG T Sbjct: 264 PLKAK----HPLTELDNVILTPHIGWKT 287 >UniRef50_Q8EP33 Glycerate dehydrogenase n=2 Tax=Bacillaceae RepID=Q8EP33_OCEIH Length = 314 Score = 142 bits (359), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 95/284 (33%), Positives = 146/284 (51%), Gaps = 11/284 (3%) Query: 24 LESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFC 83 +E+L G I ++ E+LK+++R+ I + + + +++I+AA L I F Sbjct: 19 VENLNRLGNVTILDTDNGIEKEKLKQAVREVEVI-ITAVVQIDKEIIDAAPNLKYIMKFG 77 Query: 84 IGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLA 143 G + +D A ++GIPV N P N +VA+L IG +L R +P N + G W +L+ Sbjct: 78 AGYDNIDFKYAREKGIPVTNTPGQNADAVADLAIGLMLATARNIPAKNEELRNGNW-ELS 136 Query: 144 AGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQH--LSDLL 201 G E KKLGIIG+G IG + A M V Y + + V+ L+ LL Sbjct: 137 MG-IEIFQKKLGIIGFGAIGQAIAQRATGFQMEVLAYGTFQDQTIADRLNVEFVDLNKLL 195 Query: 202 NMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGA 261 N SD+V + ++ AK ++ +K +L IN SRG +VD AL +AL + + GA Sbjct: 196 NESDIVVVSTTLRKDNYQLINAKTLNEIKKDALFINVSRGALVDEDALYEALTNGKIKGA 255 Query: 262 AIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 +DVF EP+ + PL N +TPHIG +T EA + G Sbjct: 256 GLDVFVEEPSHH------PLLTLPNTTVTPHIGAATNEAIKRTG 293 >UniRef50_Q2NA55 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=4 Tax=Sphingomonadales RepID=Q2NA55_ERYLH Length = 338 Score = 142 bits (359), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 97/282 (34%), Positives = 142/282 (50%), Gaps = 15/282 (5%) Query: 45 EQLKESIRDAHFIGLRSRTHLTEDVI-NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFN 103 EQL ++ D + + D+I A E+L I F GT+ +DL AAAKR I V N Sbjct: 50 EQLAAAMADCDVLVPTVTDRIDADLIAGAGERLKLIANFGAGTDHIDLAAAAKRKIMVTN 109 Query: 104 APFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEAR---GKKLGIIGYG 160 P T A++ + ++ + R + E G W A R GK LGI+G G Sbjct: 110 TPSVFTDDTADIAMLGIIGVPRRIREGVELVRSGKWTGWAPSGMLGRKIGGKVLGIVGMG 169 Query: 161 HIGTQLGILAESLGMYVYFYDIENKLP-----LGNATQVQHLSDLLNMSDVVSLHVPENP 215 IG + A++ G+ + +++ +LP + A V L L+ +D++SLH P Sbjct: 170 RIGQAVAHRAKAFGLDIAYHN-RKRLPEAVERMLGARFVGDLDTLVAEADILSLHCPATQ 228 Query: 216 STKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSD 275 T M+ A+ I LMKPG+ LIN +RG +VD AL AL HLAGA +DV+P EP + Sbjct: 229 DTIGMLDARRIGLMKPGASLINTARGELVDQEALISALEQGHLAGAGLDVYPDEPNVDKR 288 Query: 276 PFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSD 317 P NV+ PHIG +T E +E G +V + ++D Sbjct: 289 LIRHP-----NVMTLPHIGSATAEGREASGEKVIANIRFWAD 325 >UniRef50_Q2YBY5 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=4 Tax=Nitrosomonadaceae RepID=Q2YBY5_NITMU Length = 315 Score = 142 bits (358), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 84/252 (33%), Positives = 138/252 (54%), Gaps = 10/252 (3%) Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 LTE V + A L + G + VDL AA + GI V N P + ++VAEL + ++ L Sbjct: 61 LTERVFSCARSLKVVSRCGSGLDSVDLGAAKRHGIKVLNTPEAPAQAVAELSLALIMAAL 120 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 R + + + + G W + G A +K+GI+G G +G+++ L + V +D Sbjct: 121 RKICQTDKQVRAGQWPRAQGGLLAA--QKVGIVGLGRVGSRVARLCRAFEAQVVAHDTYV 178 Query: 185 K-LPLG-NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 K +P G ++ L+ +D++SLH+ + T +++ K + MKPG+++IN +RG Sbjct: 179 KEMPPGMEGVKLVPFETLIAEADIISLHLTYDADTHHLLNEKTFARMKPGAIVINTARGG 238 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 ++D AL DAL S L GAA+DVF E P+ PL + DN +LT HIG +E+++ Sbjct: 239 LIDEAALADALNSGQLGGAAMDVFEQE------PYHGPLLQCDNAILTSHIGSLAKESRQ 292 Query: 303 NIGLEVAGKLIK 314 + LE A L++ Sbjct: 293 RMELEAAENLVR 304 >UniRef50_A7VV70 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753 RepID=A7VV70_9CLOT Length = 316 Score = 142 bits (358), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 95/267 (35%), Positives = 134/267 (50%), Gaps = 14/267 (5%) Query: 45 EQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNA 104 E+L E ++A + + ++T L+ +I + + L IG G N VD+ AA K GIPV N Sbjct: 36 EELYERAKEAELL-ITNKTVLSGKMIRSLKNLKYIGTLSTGFNVVDIHAARKLGIPVCNV 94 Query: 105 PFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNK------LAAGSFEARGKKLGIIG 158 P T +VA++ L L V N H+G W A E K G+ G Sbjct: 95 PSYCTNAVAQMTFSLLFALTNHVALHNHSVHQGDWENSTDFCYWKAPLVELESKNFGVYG 154 Query: 159 YGHIGTQLGILAESLGMYVYFYDIENK-LPLGNATQVQHLSDLLNMSDVVSLHVPENPST 217 +G IG + +A LGM V Y K +P G Q +L SDV+SLH P P T Sbjct: 155 FGSIGRTVAKIAADLGMNVLVYSRTKKDMPSGYRWVSQE--ELFRESDVLSLHCPLTPET 212 Query: 218 KNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPF 277 ++ K +SLMKP + LIN SRG V+ L +AL LAGAA+DV EP +P Sbjct: 213 TGLVNRKTLSLMKPTAYLINTSRGQVIREQDLAEALNGGRLAGAAMDVLCEEPPEKGNPL 272 Query: 278 TSPLCEFDNVLLTPHIGGSTQEAQENI 304 T CE ++TPHI + +E+++ + Sbjct: 273 TH--CE--KCVITPHISWAAKESRDRL 295 >UniRef50_B0MXJ8 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM 17216 RepID=B0MXJ8_9BACT Length = 312 Score = 142 bits (358), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 97/268 (36%), Positives = 142/268 (52%), Gaps = 15/268 (5%) Query: 46 QLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAP 105 ++ E DA + + ++ L + I +L I G N VDL+AAA+RGI V NA Sbjct: 35 EIAERCIDADIV-ITNKVPLRAEAIKVLPQLKLICIAATGMNNVDLEAAAERGIEVRNAV 93 Query: 106 FSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEAR------GKKLGIIGY 159 +T +V E IG + LLR + G + A R GK+ GIIG Sbjct: 94 GYSTHAVTETTIGAAIALLRQSIYYDRYVKSGEYAASDAPFHFGRPLHQLYGKRWGIIGL 153 Query: 160 GHIGTQLGILAESLGMYVYFYD---IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPS 216 G IG ++ +A +LG + + +E + P L +LL SD+VS+H P N Sbjct: 154 GAIGHKVAEVAAALGCQIAYTSTSGVERQEPY----PAMPLDELLRWSDIVSIHAPLNDR 209 Query: 217 TKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDP 276 T+ ++GA+E++LMKP +LLIN +RG +VD AL DAL +K LAGA IDVF EP + +P Sbjct: 210 TRGLVGARELALMKPSALLINVARGGIVDEQALADALDNKRLAGAGIDVFSREPMSPDNP 269 Query: 277 FTSPLCEFDNVLLTPHIGGSTQEAQENI 304 + + D +LL+PH + EA E + Sbjct: 270 LLR-VTDPDRLLLSPHTAWAPVEALETL 296 >UniRef50_B9KTQ4 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=4 Tax=Rhodobacteraceae RepID=B9KTQ4_RHOSK Length = 316 Score = 142 bits (358), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 99/294 (33%), Positives = 146/294 (49%), Gaps = 15/294 (5%) Query: 18 GVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLV 77 G H + + A G+T + A + L E+ D +GL +T +V+ +L Sbjct: 12 GRHGRVPARIEAEGWTFLRAADAAEMEAHLPEA--DYLVVGL---VPVTAEVLAKGPRLK 66 Query: 78 AIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRG 137 + +G + +D+ A G+PV N P +N +VAEL +G + + R +P+ +A G Sbjct: 67 GVLKHGVGVDNIDIPACTAAGLPVTNTPAANADAVAELAMGLMFAMARFIPQGHASVTSG 126 Query: 138 VWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHL 197 W++ GK LGI+G G+IG +L LA LGM V D V +L Sbjct: 127 GWDRRIGTQLG--GKVLGIVGLGNIGKRLARLARGLGMEVLATDRVEDPAFARDCGVTYL 184 Query: 198 --SDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALAS 255 +LL +D VSLHV ++ + ++ +KPG+ L+N +RG VVD+ A+ AL S Sbjct: 185 PLEELLARADYVSLHVFGGAGNAALIDDRALARLKPGARLVNLARGEVVDLDAVGRALES 244 Query: 256 KHLAGAAIDVFPTEPATNSDP-FTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L G AID + TEP S P F P N + TPH G T EA EN+GL V Sbjct: 245 GQLGGVAIDAYVTEPPDVSHPVFAHP-----NAVFTPHSGADTLEALENVGLMV 293 >UniRef50_C4ZHF5 Phosphoglycerate dehydrogenase, putative n=3 Tax=Clostridiales RepID=C4ZHF5_EUBR3 Length = 329 Score = 142 bits (358), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 94/294 (31%), Positives = 154/294 (52%), Gaps = 12/294 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +KF++ + V + ++ L + ++ D + +RDA + +R + I Sbjct: 1 MKFVMTQAVCPEGMQLLDGIADVYVADNQ---DPNNYLDEMRDAAALIVRI-AKCDANAI 56 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 + KL IG +G + VD+ A + GIPV P +N RSVAE + + L + + EA Sbjct: 57 ENSPKLKVIGRTGVGYDSVDVKKATELGIPVVITPGANNRSVAEHAVAMIFALSKNLIEA 116 Query: 131 NAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD---IENKL 186 + +G W + A +FE K +GI+G G IG + + + GM + YD + ++ Sbjct: 117 QNEMCKGNWEIRGAKKAFELERKTVGILGLGAIGRETAKICKGCGMRIAAYDPFMTKEQV 176 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 A + +LL SDVVS+HVP T+NM+ KE+S+MKP +L+IN SRG +++ Sbjct: 177 EGYGAKYYEDYVELLKDSDVVSIHVPLTDQTRNMISKKELSVMKPTALIINCSRGGIINE 236 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 L +AL + +AGA DVF +EP DP + C N++++PH T+EA Sbjct: 237 ADLVEALNNGVIAGAGTDVFCSEPPKTDDPLLN--CR--NLIVSPHSAAQTREA 286 >UniRef50_A4FHH0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FHH0_SACEN Length = 336 Score = 142 bits (358), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 99/296 (33%), Positives = 155/296 (52%), Gaps = 11/296 (3%) Query: 45 EQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNA 104 EQL + + + +RS T + VI AA+ L + GTN +D ++AA+RG+ V N Sbjct: 33 EQLPDRLTGREVLVVRS-TAVPSAVIEAADSLRLVIRAGSGTNTIDCESAAERGVHVCNV 91 Query: 105 PFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEA-RGKKLGIIGYGHIG 163 P N +VAEL +L L R V + G W+K G+++G++G G IG Sbjct: 92 PGRNAIAVAELAFALMLALDRSVCDNVDDLRAGRWDKKRYSRARGIHGRRVGVVGLGQIG 151 Query: 164 TQLGILAESLGMYVYFYDIENKLP----LGNATQVQHLSDLLNMS---DVVSLHVPENPS 216 A + G V+ + P +A ++ + DL ++ DV+SLHVP + Sbjct: 152 LAFAERAAAFGATVHAVAKPGRSPKTAERADAIGIRFVDDLTTLARTCDVLSLHVPATSA 211 Query: 217 TKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDP 276 T+N++ A ++ ++PG++++N SRG +VD AL A+ K + A IDVF EPAT + Sbjct: 212 TRNLVDADLLAHVQPGTIILNTSRGELVDEDALIAAMEEKDVR-AGIDVFTDEPATGTGH 270 Query: 277 FTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSL 332 S L NV T HIG ST++AQ + EV +++ ++GS L+ VN V L Sbjct: 271 IGSRLARHPNVYGTHHIGASTEQAQHAVAAEVV-RMVDAFESGSVLNCVNLDAVRL 325 >UniRef50_A7HM61 Glyoxylate reductase n=6 Tax=cellular organisms RepID=A7HM61_FERNB Length = 317 Score = 142 bits (357), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 94/293 (32%), Positives = 150/293 (51%), Gaps = 19/293 (6%) Query: 25 ESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCI 84 E YT EF L E++ + A I + R + ++ I + +K I + + Sbjct: 19 ERFEVDVYTGEEF----LSKEEMIKRAEYADAIVTQLRDPIDKEFIYSLKKAKIIANYAV 74 Query: 85 GTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGV---WNK 141 G N +D++AA +RGI V N P T + A++ +L + R + E++ G W Sbjct: 75 GYNNIDIEAAKERGIYVTNTPGVLTEATADIAFALILAVARRIVESDKFVREGKFVGWKP 134 Query: 142 LAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP-----LGNATQVQH 196 ++ GK LG+IG G IG + A GM + +Y+ N+LP NA V + Sbjct: 135 KLFLGYDLYGKTLGVIGMGRIGQAVARRALGFGMNIVYYN-RNRLPEEIEKQYNAKYV-N 192 Query: 197 LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASK 256 + +L+ +SD +SLH P T +++ + I+ MKP ++L+N +RG VVD AL +AL + Sbjct: 193 IDELVEISDYISLHTPLTKETYHLINKERIAKMKPNAILVNTARGPVVDEQALYEALKER 252 Query: 257 HLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 +AGA DV+ EP T L + DNV+L PHIG +T E ++ + VA Sbjct: 253 RIAGAGFDVYENEPV-----LTPGLEKLDNVVLLPHIGSATYETRDKMSEIVA 300 >UniRef50_C1XXK0 Phosphoglycerate dehydrogenase-like oxidoreductase n=2 Tax=Meiothermus RepID=C1XXK0_9DEIN Length = 313 Score = 142 bits (357), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 99/304 (32%), Positives = 153/304 (50%), Gaps = 16/304 (5%) Query: 14 LLVEGVHQKALESLRAAG---YTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 ++ E + + LE LR G Y + + K D LK + +A + +R++T + D++ Sbjct: 8 VVCEFISESGLERLRRGGVEVYYDPDLWK---DRGALKAKLAEATALIVRNQTQVDADLL 64 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +A L +G +G + + RG+ ++ A N VAE V+ +L L R + A Sbjct: 65 SAGPNLKVVGRLGVGLDNIHQPDLKARGVQLYFARGINAGGVAEYVLAAMLHLARNLAGA 124 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 G WN+ A G E RGK LG++G G +G ++ A + GM V D +LP + Sbjct: 125 ALHVAGGGWNRSAFGGCELRGKTLGLVGLGEVGLRVAKRARAFGMRVVASD-PGRLPWES 183 Query: 191 ATQ-----VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 A + + +++L S VSLH P P T++++ A+ I+ M G+ LIN +RG +V Sbjct: 184 AVEDLEVHLTSTAEVLCASLFVSLHAPLTPQTRHLIRAETIATMPRGAYLINTARGELVH 243 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 L AL L GA +DV EP P L DN+ +TPH+ G T EAQE +G Sbjct: 244 NEDLAAALRRGQLGGAVLDVVDPEPL----PAEHVLRGVDNLWITPHVAGLTAEAQEQVG 299 Query: 306 LEVA 309 L VA Sbjct: 300 LRVA 303 >UniRef50_A4FIJ9 D-3-phosphoglycerate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FIJ9_SACEN Length = 322 Score = 142 bits (357), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 91/258 (35%), Positives = 133/258 (51%), Gaps = 7/258 (2%) Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 +++A I +G + VD AAA+RGIPV N P N +VA+ +G +L LLR Sbjct: 67 LLDAMPNCRLIQSVAVGFDGVDHVAAAERGIPVANLPGFNADAVADWTVGAMLHLLRHYA 126 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL 188 + K +G W + + I+G+G+IG + + G + +D P Sbjct: 127 AGHRKVEQGGWGPEGLRGRDLSALTVAILGFGNIGRAVARRLDGFGAEIVVHD---PFPS 183 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 Q L + + +DV+SLH+P N +T+ ++G + ++ M G+ ++NA RG V+D PA Sbjct: 184 EPGRQYVALEEAVARADVLSLHMPLNDATRGLLGDELLATMPSGAYVVNAGRGGVIDEPA 243 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L AL S HLAGAA+DVF EP P SPL D+VLLTPH G T EA N+ + Sbjct: 244 LARALDSGHLAGAALDVFAEEPL----PADSPLRGRDDVLLTPHTAGVTWEAYHNLRNRL 299 Query: 309 AGKLIKYSDNGSTLSAVN 326 KL S + VN Sbjct: 300 FDKLAAVLAGKSPVDVVN 317 >UniRef50_C0C032 Putative uncharacterized protein n=2 Tax=Firmicutes RepID=C0C032_9CLOT Length = 319 Score = 142 bits (357), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 90/273 (32%), Positives = 141/273 (51%), Gaps = 13/273 (4%) Query: 45 EQLKESIRDAH--FIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVF 102 EQ+ + I D IGL TE++ A KL I F +GT+ +D A + GI V Sbjct: 42 EQIAQVIGDVDGAIIGLDD---WTEEIYKIAPKLKVIAKFGVGTDNIDKIKAREYGIKVI 98 Query: 103 NAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHI 162 NAP N+ +VAEL +G ++ +LRG+ + K G W + +E +GK +G++G+G I Sbjct: 99 NAPGQNSNAVAELTVGLMIGVLRGLIPLHKKMENGEWVRRVG--YEIKGKTIGLLGFGAI 156 Query: 163 GTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLS--DLLNMSDVVSLHVPENPSTKNM 220 + + G V D+ L + V +S +++ SD+VS+H+P T ++ Sbjct: 157 ARLVAEKLMNFGAEVIASDLYPDAELASRCNVTMVSQKEVMTKSDLVSIHIPATGETHHL 216 Query: 221 MGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSP 280 +MK G+ LIN +RG+++D ALC AL +AGAA+D F EP + Sbjct: 217 FDDAAFRMMKKGAYLINCARGSIIDTGALCRALKDGRIAGAALDAFEAEPLMKD----AE 272 Query: 281 LCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLI 313 + + NV+ TPH G T EA N+ + A +I Sbjct: 273 ILKCGNVICTPHTGAETYEAYTNVSMCTAQGVI 305 >UniRef50_C0CRA6 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=C0CRA6_9FIRM Length = 321 Score = 142 bits (357), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 86/238 (36%), Positives = 127/238 (53%), Gaps = 9/238 (3%) Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 +TE V+ AE L I + G +++D+ AA++ G+ V N P N ++V EL G LL + Sbjct: 62 ITERVLREAEDLKVISRYGTGYDRIDMAAASQYGVTVTNTPGVNAQAVGELAFGLLLSVA 121 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--I 182 R + + G W + A E +GK LGI+G G IG + A+ GM V D I Sbjct: 122 RQISYLDRTTRSGEWVR--AEGVELKGKTLGILGLGAIGKVVARCAKGFGMRVAASDPFI 179 Query: 183 ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 + + + + + DLL+ +D VSLH+P N T +++G + ++ MK G +LIN SRG Sbjct: 180 DREYCREHGIEAMDMEDLLSFADAVSLHLPLNKETTHLIGKEALARMKDGVILINTSRGG 239 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 ++D A L S + G +D F EP P S L EF NV+ TPH G T+EA Sbjct: 240 IIDEEAAYCGLKSGKIGGLGLDAFENEP-----PKGSSLFEFSNVVATPHTGAHTKEA 292 >UniRef50_A3PPC6 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=7 Tax=Alphaproteobacteria RepID=A3PPC6_RHOS1 Length = 331 Score = 141 bits (356), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 92/260 (35%), Positives = 145/260 (55%), Gaps = 14/260 (5%) Query: 75 KLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKA 134 +L A+ G + VD +AAA++G+ V N P +N RSVAEL +G L + R +P A+ Sbjct: 62 RLRAVVVHGAGHDPVDKEAAARKGVVVANTPGANARSVAELAVGLALAVARRIPAADRAL 121 Query: 135 HRGVWNKLAAGSF-EARGKKLGIIGYGHIGTQLG-ILAESLGMYVYFYDIENKLP-LGNA 191 G + F E RG+ ++G+G G + G +LA++ M + + ++P + Sbjct: 122 REGKTGFRESARFSELRGRTALVVGWGASGRETGRMLAQAFDMRLLVHS--PRVPRIEGG 179 Query: 192 TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCD 251 +V L++ L +D+VSLH P P T +MM A+ + M+PG++LIN +R +VD AL + Sbjct: 180 ERVASLAEGLAAADLVSLHTPLRPETHHMMDARAFAAMRPGAILINMARAGLVDEAALLE 239 Query: 252 ALASKHLAGAAIDVF-PTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAG 310 A+AS HL GA +DV P P + PL NV+ TPH+GG+T+EA + LE Sbjct: 240 AVASGHLGGAGLDVCSPGAP-------SGPLAAHGNVVFTPHLGGTTEEALRRVALEAVR 292 Query: 311 KLIKYSDNGSTLSAVNFPEV 330 +I + +A+N P+V Sbjct: 293 HVITALEGRLPETAIN-PDV 311 >UniRef50_C5EP42 D-3-phosphoglycerate dehydrogenase n=2 Tax=Clostridiales RepID=C5EP42_9FIRM Length = 307 Score = 141 bits (356), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 92/267 (34%), Positives = 141/267 (52%), Gaps = 12/267 (4%) Query: 49 ESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSN 108 + I+D I LR+ H+ D+++ A L IG +G N +DL AA + GIPV N PF+N Sbjct: 28 DRIQDVDGIILRT-VHIGRDIMSRAVNLKVIGKHGVGCNTIDLAAAKELGIPVINTPFAN 86 Query: 109 TRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLA---AGSFEARGKKLGIIGYGHIGTQ 165 T SVAEL++G +L + R + + K+ + +A E GK +G++G G+I + Sbjct: 87 TNSVAELIVGLMLDISRNISACDKKSRGEGFPCIAPPEMTGIELTGKTVGLVGMGNIARR 146 Query: 166 LG-ILAESLGMYVYFYDIENKLPLGNATQVQHLSDL---LNMSDVVSLHVPENPSTKNMM 221 +G IL + YD ++ ++ DL L +SD+V++ VP PST+NM+ Sbjct: 147 MGEILKNGFNARLVGYDPYCSNGQADSYGIEKFEDLDHMLEVSDIVNISVPLTPSTENMI 206 Query: 222 GAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPL 281 + + ++LINA+RG VV+ L AL L AA D F EP + + Sbjct: 207 SSANFEHFRKNAILINAARGGVVNEDDLYQALKEGRLRAAACDAFVEEPPNGRNKLMT-- 264 Query: 282 CEFDNVLLTPHIGGSTQEAQENIGLEV 308 DN TPHIG +T+EA +G+EV Sbjct: 265 --LDNFCATPHIGANTEEALYRMGMEV 289 >UniRef50_B0PD17 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PD17_9FIRM Length = 388 Score = 141 bits (356), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 103/352 (29%), Positives = 174/352 (49%), Gaps = 33/352 (9%) Query: 75 KLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN--A 132 +L AI G N + +D +++GI VFN P +N +V ELVI LL+ R V A Sbjct: 50 ELAAIARAGAGVNNIPVDRCSEQGIVVFNTPGANANAVKELVICALLMSARRVFPAMEWV 109 Query: 133 KAHRGVWNKL------AAGSF---EARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD-- 181 + +G +++ F E GK LG+IG G IG ++ A L M V+ YD Sbjct: 110 QTLKGQGDEVPKLVEKGKSQFVGPELAGKSLGVIGLGAIGARIANFARHLDMEVWGYDPY 169 Query: 182 --IENKLPLGNATQ-VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINA 238 +E + + + L ++ D ++LH+P P TK M+ ++ I +M+ G L+N Sbjct: 170 MSVETAWNVSRSIRRASSLKEIYENCDFITLHIPSTPETKGMINSQSIQMMRHGVRLLNF 229 Query: 239 SRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQ 298 +RG ++ L L K + D FP++ L V+ PH+G ST Sbjct: 230 ARGDLIVNEDLLAGLEEKQIRCYFTD-FPSDE----------LLGHPGVMAIPHLGASTP 278 Query: 299 EAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIF 358 E+++N A +L+ Y +NG+ ++VN P VS+P G R+ IH N P +LT ++ + Sbjct: 279 ESEDNCARMAAEELVDYLENGNIKNSVNMPSVSMPRSGDFRVALIHRNIPAMLTKISVLI 338 Query: 359 AEQGVNIAAQYLQTSAQMGYVVIDIEA--DEDVAEKALQAMKAIPGTIRARL 408 ++ G+NI ++ Y +ID++ +++A K ++A+ IR + Sbjct: 339 SDAGMNIENLTNKSRQNYAYTMIDLKGAPTDELAAK----LRAVEDVIRVTI 386 >UniRef50_A0M755 D-3-phosphoglycerate dehydrogenase n=24 Tax=Bacteroidetes RepID=A0M755_GRAFK Length = 326 Score = 141 bits (356), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 95/311 (30%), Positives = 150/311 (48%), Gaps = 20/311 (6%) Query: 20 HQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAI 79 H + L AG+ NIE ++ + D + + D I +RSR + + I+AA L I Sbjct: 10 HPALMRKLEEAGHHNIEGYEQSRADTLQNQHLYDG--IVIRSRYKIDREFIDAAPNLKFI 67 Query: 80 GCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVW 139 G +D++ A +RGI +F+AP N +V E +G LL L + +A+ + G+W Sbjct: 68 ARVGAGLESIDVEYAKERGIQLFSAPEGNRNAVGEHSLGMLLSLFNKLNKADKEVREGLW 127 Query: 140 NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSD 199 + E GK +G+IGYG++G + V FYD++ + NA QV + + Sbjct: 128 QREENRGVELDGKTVGLIGYGNMGKAFAKKLRGFEVDVIFYDLKEGIADDNARQVGY-EE 186 Query: 200 LLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLA 259 +DVVSLHVP T++M + IS K IN +RG V L +AL + + Sbjct: 187 FFEKADVVSLHVPLTEETEHMFNKEFISSFKKPFWFINTARGKSVVTADLVEALKEEKVL 246 Query: 260 GAAIDVFPTEPA--------------TNSDPFTSPLCEF---DNVLLTPHIGGSTQEAQE 302 GA +DV E A + +DP L E + LL+PH+ G T+E+ + Sbjct: 247 GAGLDVLEYEKASFESLFGNKKNVSMSAADPIPEALRELMFMPHTLLSPHVAGWTKESHK 306 Query: 303 NIGLEVAGKLI 313 + +A K+I Sbjct: 307 GLATVIADKII 317 >UniRef50_B1HNB2 D-3-phosphoglycerate dehydrogenase n=7 Tax=Firmicutes RepID=B1HNB2_LYSSC Length = 319 Score = 141 bits (355), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 97/288 (33%), Positives = 150/288 (52%), Gaps = 7/288 (2%) Query: 17 EGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKL 76 + + +K E ++ AG+ + ++K D +L + A I + + + TE VI+ L Sbjct: 13 DSIIEKLAEPIKQAGHEFVYYNKKTTDSAELAKRSEGADVIMIANNPYPTE-VIDQNANL 71 Query: 77 VAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHR 136 I G + V + A + + V NA ++VAEL IG +L + R + + N + H Sbjct: 72 KLINVAFTGVDHVGIGQARNQDVMVCNAAGYANQAVAELTIGLVLDVYRRISQGNKEIHA 131 Query: 137 GVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQH 196 + GS E +GK +G+IG G IG L ++ G + D + P A +++ Sbjct: 132 DHFPGAFQGS-EIKGKTVGLIGTGKIGMMTARLFKAFGAKIVASDQSRRNPEAEALGIEY 190 Query: 197 --LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALA 254 L +LL SD+VSLH+P STK ++ +++ LMK ++LIN +RG +VD AL DAL Sbjct: 191 MELDELLAQSDIVSLHIPLLSSTKGLISKEKLELMKESAILINCARGPIVDNDALADALN 250 Query: 255 SKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 +AGA IDVF EP P L + NV+LTPH+G T EA E Sbjct: 251 EGRIAGAGIDVFDMEPPI---PGDYKLLQAKNVILTPHVGFLTNEAME 295 >UniRef50_C7TNB9 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=74 Tax=Bacteria RepID=C7TNB9_LACRL Length = 325 Score = 141 bits (355), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 88/268 (32%), Positives = 135/268 (50%), Gaps = 11/268 (4%) Query: 43 DDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVF 102 D +++ I DA + L +T LT+ +I A L IG G + +D++AA+ RGIPV Sbjct: 37 DTQKILARIGDAEIV-LTHKTPLTKAIIGKAPNLRYIGVMGDGYDVIDVEAASARGIPVT 95 Query: 103 NAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEAR------GKKLGI 156 N P T +VA+ +L + V N H G W +F A+ GK LG+ Sbjct: 96 NVPIYATDAVAQFTFALILEITSHVGLHNRLVHEGRWEASPDFTFWAKKLTLLAGKTLGL 155 Query: 157 IGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPS 216 +GYG I ++ +A + M V FYD K +Q L +LL +D++SLHV + P Sbjct: 156 VGYGRIAQKVASIAHAFSMKVVFYDRRPKTHDNQMSQQVSLKELLTTADIISLHVRQAPE 215 Query: 217 TKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDP 276 T N++ + I M+PG ++IN +RG +++ L AL +A A +DV EP + Sbjct: 216 TLNLIRRETIEQMRPGVIIINTARGKLINENDLALALNQGKIAAAGLDVSQQEPIQPDN- 274 Query: 277 FTSPLCEFDNVLLTPHIGGSTQEAQENI 304 PL N +TPHI + E +E + Sbjct: 275 ---PLLTAKNCYITPHIAWAPYETREKL 299 >UniRef50_UPI0001973D95 D-3-phosphoglycerate dehydrogenase n=1 Tax=Clostridium sp. M62/1 RepID=UPI0001973D95 Length = 322 Score = 141 bits (355), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 102/295 (34%), Positives = 158/295 (53%), Gaps = 17/295 (5%) Query: 34 NIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDA 93 N++ ++ E+ + + DA + LR +DVI + L I + G + VD++A Sbjct: 24 NLDCTLTKVETEEEYQKMTDAEIMVLRI-FKARQDVIERNKGLKMIIRWGAGFDSVDIEA 82 Query: 94 AAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNK--LAAGSFEARG 151 A K G+ V N P +N +V+EL + +L + R + + +GVW+K S+ Sbjct: 83 AGKNGVVVANTPGANAPAVSELAVMLMLAVGRHLIDHMDSLRKGVWSKNTYINQSYTLNR 142 Query: 152 KKLGIIGYGHIGTQLGILAESLGMYVYFYDI-----ENKLPLGNATQVQHLSDLLNMSDV 206 K +GIIG G+IG Q A++ G + +YD E + LG + L LL SDV Sbjct: 143 KLVGIIGAGNIGRQTAKKAQAFGAEIQYYDPFRLSPEREQELG--LRYVPLETLLKTSDV 200 Query: 207 VSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVF 266 +SLHVP S ++M+GA+EIS MK G++L+N +RG +VD AL +A+ S LAGA +DV Sbjct: 201 ISLHVPLTDSNRHMIGAEEISQMKDGAILVNTARGGLVDDQALAEAVRSGKLAGAGLDVV 260 Query: 267 PTEPATNSDP-FTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGS 320 EP D T+P +++TPH+GG T + + I L + K I+ NG Sbjct: 261 ENEPLKEDDSLLTTP-----GIVVTPHVGGGTADIGDEI-LPMLAKEIERVINGQ 309 >UniRef50_C7H045 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7H045_9FIRM Length = 388 Score = 141 bits (355), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 109/356 (30%), Positives = 172/356 (48%), Gaps = 30/356 (8%) Query: 49 ESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSN 108 E +DA GL R++ D ++ + L I G N + +D K+GI VFNAP +N Sbjct: 27 EDAKDAE--GLIVRSYDLHD-MDFDDSLRCIARAGAGVNNIPVDECTKKGIVVFNAPGAN 83 Query: 109 TRSVAELVIGELLLLLRGVPEA-----NAKAHRGVWNKLAAGS-----FEARGKKLGIIG 158 +V ELVI +LL R +PEA + V K+ G E RGK LG+ G Sbjct: 84 ANAVKELVIAGMLLAARNIPEALKWVNTLEMTDDVAKKIEKGKGQFAGTELRGKTLGVFG 143 Query: 159 YGHIGTQLGILAESLGMYVYFYD----IENKLPLGNATQ-VQHLSDLLNMSDVVSLHVPE 213 G IG Q+ AE LGM V YD + + + L + V + L D +SLH+P Sbjct: 144 LGAIGVQVANAAEKLGMKVIGYDPYMTVNSAVKLTRKIKLVTSIEGALPECDYISLHIPA 203 Query: 214 NPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATN 273 TK M+ + +S +K G+ L+N +R ++D AL AL S L Sbjct: 204 IDETKGMVNQEFLSKVKEGATLLNFARDKLIDDDALIYALKSGKLKKYI----------- 252 Query: 274 SDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSL- 332 +D T+ L + V+ PH+G S+ EA+EN +++ Y +NG+ +++VNFP SL Sbjct: 253 TDFTTAKLFGKEGVISIPHLGASSAEAEENCATMAVVEMMDYLENGNIVNSVNFPNCSLG 312 Query: 333 PLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADED 388 R+ I+ N G+L+ + + G+N+ ++ Y +++++ D D Sbjct: 313 EKDEAARISIINSNVSGMLSKITGALGDVGINVENLINKSKGDYAYTLLEVKKDVD 368 >UniRef50_A6FZB7 Putative dehydrogenase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6FZB7_9DELT Length = 337 Score = 140 bits (354), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 93/263 (35%), Positives = 134/263 (50%), Gaps = 16/263 (6%) Query: 50 SIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNT 109 ++ DA I + SR L D + E+ I C +G VDL+AA RGIPV N P T Sbjct: 47 ALADADAIIVWSRFELDADALATLERCRGIVCASVGYEHVDLEAARARGIPVCNVPDYGT 106 Query: 110 RSVAELVIGELLLLLRGVPEANAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGI 168 VA+ LL L R + + G W+ +L RG+ LG++G+G IG Sbjct: 107 EEVADHATALLLGLARKLAVLDRSVREGQWDWQLGGMPTRLRGQSLGVVGFGRIGAAFTR 166 Query: 169 LAESLGMYVYFYDIENKLPLG-----NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGA 223 A++ G+ F+D +P G + + L +LL + V+S+H NP+ + ++GA Sbjct: 167 RAQAFGLEPAFFD--PHVPSGVEKVLGVRRCESLDELLEGAQVLSIHASANPANRGLIGA 224 Query: 224 KEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDP--FTSPL 281 + ++ + G+LLIN +RG++VD A+ DALAS L GA +DV EPA P SP Sbjct: 225 EALAKLPRGALLINTARGSLVDTQAVVDALASGQLGGAGLDVLAEEPAPELHPGLLASP- 283 Query: 282 CEFDNVLLTPHIG-GSTQEAQEN 303 VLLTPH S Q EN Sbjct: 284 ----KVLLTPHAAWASAQSFAEN 302 >UniRef50_A6CKS4 Putative uncharacterized protein n=2 Tax=Bacillaceae RepID=A6CKS4_9BACI Length = 322 Score = 140 bits (353), Expect = 8e-32, Method: Compositional matrix adjust. Identities = 108/308 (35%), Positives = 161/308 (52%), Gaps = 37/308 (12%) Query: 43 DDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVF 102 ++E L + D I +R+ L+ VI A KL I IG + +DL+AA+ RGI V Sbjct: 33 NEETLISHVSDVDAILIRT-AKLSRVVIEKASKLKVIARHGIGVDNIDLEAASDRGILVT 91 Query: 103 NAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEAR---------GKK 153 NAPF+N +VAE V L L+L G ++ V + L G FE R GK Sbjct: 92 NAPFANVNAVAEHV---LTLILSG-----SRQLIQVDSALRNGDFEVRNRKFGIELKGKT 143 Query: 154 LGIIGYGHIGTQLGILAES----LGMYVYFYDI----ENKLPLGNATQV-QHLSDLLNMS 204 LG++G+G+IG ++AE LGM V YD EN + + Q+ Q LS++L S Sbjct: 144 LGVVGFGNIGQ---LVAEKCHYGLGMDVLVYDPYVREEN---VSSYVQLNQSLSEVLASS 197 Query: 205 DVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAID 264 D+V++HVP PST +++ + + MK ++L+NA+RG ++D AL AL S + GA +D Sbjct: 198 DIVTIHVPYLPSTHHLINEEALQQMKKDAILVNAARGGIIDEIALEKALGSGEIRGACLD 257 Query: 265 VFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSA 324 F TEP L +NV++TPH+ T+EA + + A +I L Sbjct: 258 CFETEPPA----VDHSLWNLENVIVTPHLAAHTEEAMIEMAVTPAKDIIAIMKGEKPLYP 313 Query: 325 VNFPEVSL 332 VN E+ + Sbjct: 314 VNEKEIKV 321 >UniRef50_Q1GAM7 D-isomer specific 2-hydroxyacid dehydrogenase n=1 Tax=Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 RepID=Q1GAM7_LACDA Length = 322 Score = 140 bits (353), Expect = 8e-32, Method: Compositional matrix adjust. Identities = 91/269 (33%), Positives = 147/269 (54%), Gaps = 17/269 (6%) Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 +++++A +KL + +G + +D+D A+ +GI V N P S + AE+ LL L R Sbjct: 62 QELLDAGKKLKIVSATGVGYDHIDVDYASSQGIIVSNCPASVMQPTAEMAFTLLLALSRK 121 Query: 127 VPEANAKAHRGVWNKLAAGSFEARG-----KKLGIIGYGHIGTQLGILAESLGMYVYFYD 181 + N + + N L G E +G K LGI G G IG L A + GM + +++ Sbjct: 122 LALYNQEMRQ--ENFLDTGLLENQGQSPVGKTLGIFGMGRIGKTLASYARTFGMNILYHN 179 Query: 182 IENKLPLG--NATQVQH--LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLIN 237 ++LP A V + L+DLL+ +D VSL+ P T +++ +S+M+P + LIN Sbjct: 180 -RHQLPEDEERALGVSYVPLADLLSQADYVSLNAPATAETYHVIDEAALSMMQPTAFLIN 238 Query: 238 ASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGST 297 SRG+ VD AL AL K +AGA +DVF EP F C+ DNV+LTPH G +T Sbjct: 239 TSRGSQVDEAALLRALKGKRIAGAGLDVFEEEP-----DFNKEFCQLDNVILTPHAGSAT 293 Query: 298 QEAQENIGLEVAGKLIKYSDNGSTLSAVN 326 +E++ ++ E + ++ + +G ++ VN Sbjct: 294 RESRRSVLKEASHNIVSFLVDGVPVNRVN 322 >UniRef50_C6PW23 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Clostridium carboxidivorans P7 RepID=C6PW23_9CLOT Length = 346 Score = 140 bits (353), Expect = 8e-32, Method: Compositional matrix adjust. Identities = 87/246 (35%), Positives = 133/246 (54%), Gaps = 16/246 (6%) Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 +++ +I+ A+KL IG G + + AA +GI V N P N R+VAE +G +L + Sbjct: 81 ISKKIIDKAKKLKIIGVLRGGVENIAYEYAAIKGITVMNTPGRNARAVAEFAMGMILSEV 140 Query: 125 RGVPEANAKAHRGVWNKLAAGSF---EARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD 181 R + ++A +G W K + E K +GI+G+G IG + ++ G V YD Sbjct: 141 RNIARSHAALKKGEWRKKFPNTGDIPELCNKTVGIVGFGSIGQLVAGYLKAFGCNVIAYD 200 Query: 182 IENKLPLGNA----TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLIN 237 P N + L LL SDV+++H T +++G KEISLMKP ++L+N Sbjct: 201 -----PFFNGNFDGVNIVELPYLLKNSDVITVHARLTEDTYHLIGGKEISLMKPNAVLVN 255 Query: 238 ASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGST 297 +R +VD AL +AL ++GAA+DVF EP +D L + DNV +TPH+ GST Sbjct: 256 TARSGLVDEKALKEALEEGKISGAALDVFDVEPLEEND----ILMKLDNVTITPHVAGST 311 Query: 298 QEAQEN 303 ++A N Sbjct: 312 KDAFTN 317 >UniRef50_B3T034 Putative D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein n=1 Tax=uncultured marine microorganism HF4000_001L24 RepID=B3T034_9ZZZZ Length = 311 Score = 140 bits (353), Expect = 9e-32, Method: Compositional matrix adjust. Identities = 88/289 (30%), Positives = 150/289 (51%), Gaps = 7/289 (2%) Query: 39 KGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRG 98 K L +E++ + I D + +RS T +T+++I AA+KL I G + +D+ A + Sbjct: 28 KTGLSEEEIIKIIPDYDGMVVRSATKVTKNIILAAKKLKVIARAGAGVDNIDVPTAKENN 87 Query: 99 IPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIG 158 + V N P N + AE + ++ +LR +P AN H+G W K E K LGI+G Sbjct: 88 MLVMNTPGGNANATAEHALALIMSVLRKIPYANDTTHKGKWEKKNIKGAELSKKTLGIVG 147 Query: 159 YGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLS--DLLNMSDVVSLHVPENPS 216 +G++G +L L + + + + + V+++S +L++ SD++S H P Sbjct: 148 FGNVGARLSNLVKGFEVNILVSSKSLESRQKDFPHVKNVSFDELISASDIISFHCKSAPD 207 Query: 217 TKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDP 276 K ++ + MKP + +IN +RG +VD L AL +AGAA+DV+ EPA + Sbjct: 208 GKPIINKEHYKKMKPSTFIINTARGNIVDEKDLNAALNGNLIAGAALDVYSKEPAKENIL 267 Query: 277 FTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAV 325 F +P V+LTPH+ ST EA + A ++ + G+ ++AV Sbjct: 268 FNNP-----KVILTPHVAASTAEASIVVAEMAANQISNFLLKGNKINAV 311 >UniRef50_Q65WI5 SerA protein n=1 Tax=Mannheimia succiniciproducens MBEL55E RepID=Q65WI5_MANSM Length = 326 Score = 140 bits (352), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 87/261 (33%), Positives = 135/261 (51%), Gaps = 9/261 (3%) Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA 132 A+ L IG +G + VD+ A + GIPV AP SNTRSVAE + + + ++ Sbjct: 62 AKNLKVIGRPGVGVDDVDVKTATELGIPVVIAPGSNTRSVAEHAFALMFACAKDIVRSDN 121 Query: 133 KAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD---IENKLPL 188 + +G + + + ++E K L +IGYG IG+ L +++++GM V YD + + Sbjct: 122 EMRKGNFAIRSSYKAYELNHKTLALIGYGRIGSILAQMSKAIGMNVKVYDPFVKQGTIEQ 181 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 L D++ S V+S+HVP T+N++G E SLM ++LIN +RG V+D P Sbjct: 182 EGYIYCTELDDVIRDSHVISIHVPLTNETRNLIGEHEFSLMNEHTILINCARGEVIDEPV 241 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L L + A +DVF EP SPL + DNV+++PH+ G T+EA + Sbjct: 242 LTKVLQEGKIHSAGLDVFACEPVD----INSPLFQLDNVIVSPHMAGQTKEAASGVATMA 297 Query: 309 AGKLIKYSDNGSTLSAVNFPE 329 A ++ NG V PE Sbjct: 298 AEGVVAVI-NGEKWPYVCNPE 317 >UniRef50_Q031D4 D-3-phosphoglycerate dehydrogenase n=9 Tax=Streptococcaceae RepID=Q031D4_LACLS Length = 398 Score = 139 bits (351), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 108/354 (30%), Positives = 169/354 (47%), Gaps = 28/354 (7%) Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA 132 +++L+AIG G N + ++ A +GI VFNAP N +V ELV+ ++ R + AN Sbjct: 50 SKELLAIGRAGAGFNNIPIEKCASKGIVVFNAPGGNANAVKELVLSMMIFGTRNLKPANK 109 Query: 133 --KAHRG--------VWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD 181 +G V N K A E GK LG+IG G+IG+++ A+ LGM V YD Sbjct: 110 WLTGQKGNDKAIDVAVENGKKAFSGSEISGKTLGVIGLGNIGSKVANDAQRLGMKVIGYD 169 Query: 182 ----IENKLPLGN-ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLI 236 IE+ L + +V LS++ +D +++H P TK M+ K +S K G +L+ Sbjct: 170 PYLSIEHAWNLSHHVKRVNDLSEIFEKADYITVHTPATDETKGMLNWKNLSKCKNGVILL 229 Query: 237 NASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGS 296 N +R + D A+ A+ + F T D + V LTPH+GGS Sbjct: 230 NYARDEISDKEAILKAIDE-----GIVRFFGT------DFGSEKFYHHPQVFLTPHLGGS 278 Query: 297 TQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNK 356 T EA N + Y G +++VNFP V L+ R+ I++N P V+ ++ Sbjct: 279 TAEASLNCTRMALDSVQTYLKTGEIINSVNFPRVLQELNTPYRVTLINKNVPNVVAQISI 338 Query: 357 IFAEQGVNIAAQYLQTSAQMGYVVIDI-EADEDVAEKALQAMKAIPGTIRARLL 409 AE+ +NIA + Y ++D+ E DE + +A +R RL+ Sbjct: 339 AVAEENINIANIVNRGQGDFAYTLLDLDEKDERKLAALVSRFEASENIVRVRLI 392 >UniRef50_Q03YV3 Lactate dehydrogenase related enzyme n=2 Tax=Leuconostoc RepID=Q03YV3_LEUMM Length = 314 Score = 139 bits (351), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 89/263 (33%), Positives = 137/263 (52%), Gaps = 13/263 (4%) Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 D+++A L I +G + VD+DAA +RGI V N P + + SVAE + ELL + + + Sbjct: 57 DIMDAMPNLKVIARNGVGYDAVDVDAATQRGIYVVNTPKALSGSVAETAVSELLAISKNL 116 Query: 128 PEANAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL 186 + + H WN + A + GK +GI+G+G IG Q+ + V +D Sbjct: 117 YQDSKAIHDDNWNYRKAHPGRDIEGKTVGILGFGRIGQQVAKKLSGFDVKVIAFD----- 171 Query: 187 PLGNATQVQHLSD---LLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 P L D + +D V +H+P P T++ +GA E LMK + LIN +RG++ Sbjct: 172 PFAKDVPGVELVDRETIFKTADYVMVHLPALPETQHSIGADEFKLMKNDAFLINMARGSI 231 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 + L AL S +AGAA+DVF EP P T+PL +NVLLTPHI +T E + Sbjct: 232 LVESDLVLALKSGEIAGAALDVFEEEPL----PVTNPLVALENVLLTPHIASNTVETKAR 287 Query: 304 IGLEVAGKLIKYSDNGSTLSAVN 326 + ++ +++ + SAVN Sbjct: 288 MAVDATNDIVRVLSGKNPESAVN 310 >UniRef50_C7RDP2 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=3 Tax=Anaerococcus RepID=C7RDP2_ANAPD Length = 315 Score = 139 bits (350), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 105/284 (36%), Positives = 142/284 (50%), Gaps = 12/284 (4%) Query: 20 HQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAI 79 H++ +ESL G+ F + DE+ E ++D I + + LT VIN KL I Sbjct: 19 HKEKIESL---GHEFEYFEESTGSDEEKIERLKDTD-IAIITNKPLTSQVINNT-KLDLI 73 Query: 80 GCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVW 139 G + VDL+A ++GI V NA + SVAELVIG + +LR E G Sbjct: 74 DVAFTGVDHVDLEACKEKGIKVLNASGYSDDSVAELVIGLTISVLRKFNENRGNIFDGEN 133 Query: 140 NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL-GNATQVQHLS 198 N L +GK G+IG G+IG++L L G + Y K + + L Sbjct: 134 NYLLGELI--KGKTFGVIGTGNIGSKLIDLLSVFGCKIIAYSRTEKEEIKAKGVEYVDLP 191 Query: 199 DLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHL 258 LL SD+VSLH+P N TK +G++E+ LMK G++LIN +RG VVD L L L Sbjct: 192 TLLKESDIVSLHIPNNKETKGFLGSEELDLMKEGAVLINCARGAVVDNDYLAKLLNEDKL 251 Query: 259 AGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 A IDVF EP P PL NV+LT H+ T+EA E Sbjct: 252 R-AGIDVFDMEPPL---PEDYPLRNAKNVILTNHVAFYTKEAME 291 >UniRef50_B9Z038 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Lutiella nitroferrum 2002 RepID=B9Z038_9NEIS Length = 338 Score = 139 bits (349), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 121/307 (39%), Positives = 170/307 (55%), Gaps = 11/307 (3%) Query: 6 LEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 L + ++ L+ + + A+E +R G E+ L L+E I D + +RS T L Sbjct: 33 LPVEHVRVLVCDPIPSVAVERMREGGLLVDEWI--GLSPAMLEELIGDYDAVVVRSATRL 90 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 + AA++L I +GT+ +DL AAA +GI V N P ++T SVAEL +G LL L R Sbjct: 91 GAQQLAAAQRLRLIVRAGVGTDNIDLAAAASQGIAVLNTPKASTGSVAELALGMLLALAR 150 Query: 126 GVPEANAKAHRGVWNKLA-AGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 +P+A+A G W K + E GK LGIIG G IG LG A +LGM V D Sbjct: 151 RIPQADAAVKSGGWPKKEFSDGIELAGKTLGIIGVGRIGGALGRCAAALGMVVVGADKAA 210 Query: 185 KLPLGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 + P+G + L LL +D VS+H P + + + ++G KEI+ MK G LL+N +RG Sbjct: 211 E-PVGRFEGLALLSLEALLACADFVSIHTPPSKAGRAVIGKKEIARMKDGVLLVNCARGG 269 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 +VD AL AL S + GAA+DVF EP P L +V+ TPH+G ST+EAQ Sbjct: 270 LVDEEALLTALDSGKVRGAALDVFAGEP-----PSDLRLARHPHVICTPHLGASTREAQA 324 Query: 303 NIGLEVA 309 IG+E+A Sbjct: 325 RIGVEIA 331 >UniRef50_D1W6S1 4-phosphoerythronate dehydrogenase n=4 Tax=Prevotella RepID=D1W6S1_9BACT Length = 329 Score = 139 bits (349), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 84/266 (31%), Positives = 136/266 (51%), Gaps = 11/266 (4%) Query: 45 EQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNA 104 E++ E +DA + L ++ + D+I +L IG G N +D+ AA + G+ V N Sbjct: 47 EEVVERAKDAQIV-LVNKVSMKADIIAQLPQLKYIGVLATGFNHIDVKAAQEHGVTVCNI 105 Query: 105 PFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSF------EARGKKLGIIG 158 P +T SVA++V + + V + G W+K + + E GK +GI+G Sbjct: 106 PSYSTYSVAQMVFASIFTITNRVEHYAQQTREGQWSKRSDFCYWDTPLLELAGKTMGIVG 165 Query: 159 YGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTK 218 G+IG ++ +A GM VY Y +N + L + Q L L ++SD++SLH P + T+ Sbjct: 166 LGNIGMKVARIAREFGMEVYAYTSKNSVDLPSGIQKTTLDGLFSVSDILSLHCPLSERTR 225 Query: 219 NMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFT 278 ++ A + MK G++LIN RG +V+ + AL S LA DV +EP + Sbjct: 226 ELIKADNLRKMKHGAILINTGRGPLVNEADVAAALESGQLAAYGADVMCSEPPAADN--- 282 Query: 279 SPLCEFDNVLLTPHIGGSTQEAQENI 304 PL + N +TPHI +T EA+ + Sbjct: 283 -PLLKQPNAFITPHIAWATVEARSRL 307 >UniRef50_UPI0001B416D9 D-3-phosphoglycerate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI0001B416D9 Length = 300 Score = 138 bits (347), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 83/278 (29%), Positives = 147/278 (52%), Gaps = 9/278 (3%) Query: 38 HKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKR 97 +K + ++L E I+D + +RSRT +T+DVI+ +KL I IG + +D D A ++ Sbjct: 27 YKPKISSQELLEVIKDYDVVVVRSRTKITKDVISNGKKLKIIARAGIGVDNIDTDYAEEK 86 Query: 98 GIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGII 157 I V AP S+T SV E+ + +++ R + + + + KL E GK LGI+ Sbjct: 87 HIKVVYAPGSSTESVVEITLAMMVIGARSLYKGMENTRKNDFTKLKG--MELEGKTLGIL 144 Query: 158 GYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLS--DLLNMSDVVSLHVPENP 215 G+G IG + + + M YD +P+ V+ +S +L+ SDV+S++V Sbjct: 145 GFGRIGKAIVDASRTFKMKFIAYD---PMPVEYPEYVKKVSLDELMEQSDVISINVTMRK 201 Query: 216 STKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSD 275 + ++ E+S +K G +++N SR ++ + L + ++ DVF EPA + Sbjct: 202 DSPYILNDNELSKLKEGVIIVNTSRARAINGKDMLKYLKNGKISAFVSDVFWNEPA--KE 259 Query: 276 PFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLI 313 + + + DNV++TPH+G T+EAQ+ I + A +I Sbjct: 260 EYEMEMLKLDNVMITPHLGAQTKEAQKRIAIMTADNII 297 >UniRef50_B1M476 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=3 Tax=Proteobacteria RepID=B1M476_METRJ Length = 326 Score = 138 bits (347), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 104/295 (35%), Positives = 143/295 (48%), Gaps = 19/295 (6%) Query: 14 LLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAA 73 L+V+ +H L+ LRAAG D E L + D + R+ T I AA Sbjct: 7 LIVQPIHAAGLDRLRAAGLE--PRPASGTDSETLAREVADCVAVITRN-TGFPARAIAAA 63 Query: 74 EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAK 133 L IG GT+ V A GI V N P +N SVAE + + L + +PEA+ Sbjct: 64 PALRVIGVHGTGTDHVATAEATAAGIVVVNTPGANAVSVAEQTLALIFALAKALPEADRS 123 Query: 134 AHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY-------DIENK 185 G + K A E G LG++G+G IG LA +LG+ V Y D N Sbjct: 124 VRTGDDSFKFTARLIELAGLTLGLVGFGAIGQATARLAAALGLRVLAYGPSRPDADFANA 183 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 A + + LL +D+VSLHVP P T+ ++G +++ MK + LIN SRG ++D Sbjct: 184 ----GALRAASVDALLAEADIVSLHVPLTPGTRGLIGRDQLARMKREAFLINTSRGGLID 239 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 AL +AL + +AGA +DVF EP P PL +LTPH+GGST A Sbjct: 240 EAALVEALEAGTIAGAGLDVFAQEPL----PVDHPLARQPRAILTPHVGGSTGAA 290 >UniRef50_A1AQ02 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=10 Tax=Bacteria RepID=A1AQ02_PELPD Length = 318 Score = 137 bits (345), Expect = 8e-31, Method: Compositional matrix adjust. Identities = 86/230 (37%), Positives = 123/230 (53%), Gaps = 9/230 (3%) Query: 85 GTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRG----VWN 140 G N +D+ AA RGI V N P +T +VA+L I +L L + + RG Sbjct: 78 GYNNIDIAAARSRGIGVCNVPSYSTDAVAQLAITFMLNLSASLVQQQTMLRRGNLDNFQK 137 Query: 141 KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDL 200 L FE GK LG+IG+G IG ++ +A +LGM + + + L + L +L Sbjct: 138 SLQLPHFELNGKTLGVIGFGEIGRRVIAIARTLGMKIIVHSRTPRPELDPDLRFVSLEEL 197 Query: 201 LNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAG 260 L SD VSLH P N +T++++ A+ + +MKP + +IN SRG ++ PAL AL +AG Sbjct: 198 LATSDFVSLHCPLNDATRHVINAERLEMMKPTAFIINTSRGPLIHEPALSQALTRGTIAG 257 Query: 261 AAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN-IGLEVA 309 A +DV EP DP S +NV+LTPHIG E ++ IGL A Sbjct: 258 AGLDVQEQEPPEPGDPLYS----LENVILTPHIGWKRLETRQRLIGLTAA 303 >UniRef50_Q46NL3 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=2 Tax=Burkholderiales RepID=Q46NL3_RALEJ Length = 337 Score = 137 bits (344), Expect = 9e-31, Method: Compositional matrix adjust. Identities = 96/279 (34%), Positives = 144/279 (51%), Gaps = 13/279 (4%) Query: 40 GALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGI 99 GA D+ L++ I A GL R L D+ +L A+ +G + + +D A GI Sbjct: 42 GAASDQALRDRI--AKVDGLIVRRQLPGDLFEREHRLRAVVRHGVGVDFIPVDRATAHGI 99 Query: 100 PVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNK-LAAG--SFEARGKKLGI 156 PV N P +N+ +VAE I +L + R + + G WN+ + AG S E RG LGI Sbjct: 100 PVANTPDTNSNAVAEYAIAAMLAMTRRLATFDKAVRDGDWNRRMIAGEQSRELRGSTLGI 159 Query: 157 IGYGHIGTQLG-ILAESLGMYVYFY-DIENKLPLGNATQVQHLSDLLNMSDVVSLHVPEN 214 IG+G IG ++ I M + + +KLP + T + L+DL SD + L P Sbjct: 160 IGFGAIGRRVAEIAGAGFAMKLLAHTSTPSKLP-PHVTPAE-LADLFARSDYIVLACPLT 217 Query: 215 PSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNS 274 +T+ M+ ++ +P ++L+N +RG ++ L DAL+S + GA +DVF P Sbjct: 218 KATRGMVNKALLAHARPTTVLVNVARGPIIQQADLIDALSSGTIGGAVLDVFEQHPL--- 274 Query: 275 DPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLI 313 P SPL NVLLTPHI G TQ+A +GL A ++ Sbjct: 275 -PDDSPLRALQNVLLTPHIAGLTQDASMAMGLAAADTML 312 >UniRef50_D1CI00 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=14 Tax=Bacteria RepID=D1CI00_THET1 Length = 353 Score = 136 bits (343), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 100/283 (35%), Positives = 140/283 (49%), Gaps = 15/283 (5%) Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 LT V AA+ L + G V+L+AA + G+ V N P N ++ AE +G +L + Sbjct: 78 LTARVFAAADSLRLVVVTRGGPVNVNLEAATRHGVVVCNIPGRNAQAAAEYALGMILAAV 137 Query: 125 RGVPEANAKAHRGVWN----KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 R + EA++ G W FE G +G++G+G IG + +LG V + Sbjct: 138 RRIAEAHSSLVGGRWRGDLYAYEEAGFELGGSTVGLVGFGAIGRIVARALTALGAQVLVH 197 Query: 181 DI----ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLI 236 D E +G A L +LL S VVSLH T ++G EI LM GS L+ Sbjct: 198 DPYVTDEEVRAVGAART--SLEELLRSSRVVSLHARLTSETAGLIGRHEIQLMPRGSALV 255 Query: 237 NASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGS 296 N +RG ++D AL +AL S HL AA+DVFP EP P SPL V+++PHI G+ Sbjct: 256 NTARGGLLDYSALIEALESGHLWAAALDVFPEEPL----PPDSPLLTMPRVVVSPHIAGA 311 Query: 297 TQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRR 339 T+E + A ++ +Y G TL V PEV H RR Sbjct: 312 TRETAKRAARLAAVQVGRYL-RGETLQHVLNPEVMEIRHADRR 353 >UniRef50_A8HPR9 Predicted protein (Fragment) n=1 Tax=Chlamydomonas reinhardtii RepID=A8HPR9_CHLRE Length = 269 Score = 136 bits (343), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 91/235 (38%), Positives = 126/235 (53%), Gaps = 15/235 (6%) Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I A L I G N +D++AA +RG+PV AP N+ SVAE+ + +L+L R V E Sbjct: 26 IAAVRDLRLIAQPAAGYNNIDVEAAKRRGVPVTIAPGYNSHSVAEVALMMILMLSRKVDE 85 Query: 130 ANAK-AHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL 188 A A A R + G E GK LG++G G IG+ L A LGM V L + Sbjct: 86 ARAVFARRERIGEPVGG--ELHGKTLGVVGMGKIGSCLAEAARGLGMQV--------LGV 135 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + + L LL S VV+LH P +P+T+ ++G E++LM+PG+LL+N +RG+VVD A Sbjct: 136 TSRSSRAELEALLAASHVVALHCPLSPATRGLIGRAELALMRPGALLLNCARGSVVDREA 195 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 L +AL S L G +D EPA DP S VL PH+G + E + Sbjct: 196 LWEALQSGRLGGVGLDTHWVEPAPRDDPLYS----HPRVLALPHLGSISAEVYDR 246 >UniRef50_B2IKB7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=8 Tax=Proteobacteria RepID=B2IKB7_BEII9 Length = 331 Score = 136 bits (343), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 106/313 (33%), Positives = 156/313 (49%), Gaps = 24/313 (7%) Query: 14 LLVEG-VHQKALESLRAAGYTNIEFHKGALDDEQLKES----IRDAHFIGLRSRTHLTED 68 +LV G +H+ L+ LR A ++ L DE ES + A I +R++ L E Sbjct: 4 ILVAGRIHEAGLDILRNASGITLD-----LVDEVSTESYAPLVDRADAILIRTQP-LPES 57 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 VI+ A+KL + +G + VD++A +R IP+ N+RSVAE + +L + + V Sbjct: 58 VIDRAQKLKFVSRHGVGYDVVDVEALTRRNIPLAIVGDVNSRSVAEHAMMLMLAVAKRVC 117 Query: 129 EANAKAHRGVW---NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--- 182 +A G W N L A GK L +IG+G IG + +A M + YD Sbjct: 118 VYDAATRAGKWGIRNDLYATDIS--GKTLLLIGFGRIGRLVASMARGFDMTILAYDPFLD 175 Query: 183 ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 E + A + L L +D VSLH+P P ++G E++ MKPG++LIN +RG Sbjct: 176 EAAIKAAGAIPTRDLEGALRSADFVSLHMPP-PRNGALLGESELASMKPGAILINTARGG 234 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 VVD AL AL LAGA +DVF EP P PL + D V+LTPH T+E Sbjct: 235 VVDEKALAKALTDGRLAGAGLDVFTQEPP----PADHPLLQMDRVILTPHSAVMTRECAA 290 Query: 303 NIGLEVAGKLIKY 315 + + + ++ Y Sbjct: 291 RMAVSASRNILDY 303 >UniRef50_Q0K073 D-3-Phosphoglycerate dehydrogenase n=5 Tax=cellular organisms RepID=Q0K073_RALEH Length = 360 Score = 136 bits (343), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 88/259 (33%), Positives = 133/259 (51%), Gaps = 9/259 (3%) Query: 76 LVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA--K 133 L+A+ G + +D+DA + G+ V N N SVAE+ +G +L +LR + E++ + Sbjct: 85 LLAVSSSGSGCDTIDIDACTEAGVAVLNQAGGNADSVAEMTLGLMLAVLRRIAESDRSLR 144 Query: 134 AHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IENKLPLGNA 191 AH + G E RG+ LG++G GH G ++ L +LGM V D ++ Sbjct: 145 AHNCESREDLMG-HELRGRTLGLVGVGHAGRRVAALGRALGMRVIGCDPALDAAELSARG 203 Query: 192 TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCD 251 Q +LL +D+VSLH P + +T MM + M+PGS+ ++ +RG + D AL Sbjct: 204 AQAVSFEELLRSADIVSLHCPRDATTLRMMDGAAFAAMRPGSIFVSTARGGIHDEGALHA 263 Query: 252 ALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGK 311 ALAS HLAGA +DV+ EP P PL DNV+ T H G T EA+ A + Sbjct: 264 ALASGHLAGAGLDVWDQEP----PPRAHPLLALDNVVATFHTAGVTHEARRRNAELAATQ 319 Query: 312 LIKYSDNGSTLSAVNFPEV 330 ++ +G + PEV Sbjct: 320 IVTLLTSGERPERLVNPEV 338 >UniRef50_D1Y1W8 Phosphoglycerate dehydrogenase n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y1W8_9BACT Length = 343 Score = 136 bits (343), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 86/230 (37%), Positives = 131/230 (56%), Gaps = 13/230 (5%) Query: 82 FCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE--ANAKAHRGVW 139 + +G + VD++AA K+GI V N++ VAEL + +L LR +PE + AKA R Sbjct: 71 WGVGFDAVDIEAAGKKGIIVSICAGVNSQPVAELTVMLMLASLRHLPELMSRAKAGRKDK 130 Query: 140 NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI-----ENKLPLGNATQV 194 + A S+ GK++G++G G IG ++ +G V +YD E + LG + Sbjct: 131 EDIIARSWLISGKRVGLVGLGSIGRRVAAAVGGMGAEVTYYDPFRAAPETEKELG--VEF 188 Query: 195 QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALA 254 L +LL SD+VSLH+P ST++++ A ++ MKP +LL+N +RG +VD AL ALA Sbjct: 189 LPLDELLKSSDIVSLHMPLLDSTRHLIDAAALAKMKPSALLVNTARGGIVDTEALLKALA 248 Query: 255 SKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 K L GAA+D EP P P DN+++TPH GG+T++ N+ Sbjct: 249 GKCLFGAALDTIENEPL----PADHPAFSLDNLIITPHAGGNTEDNNRNM 294 >UniRef50_A1W7V5 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=3 Tax=Bacteria RepID=A1W7V5_ACISJ Length = 337 Score = 136 bits (342), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 92/277 (33%), Positives = 132/277 (47%), Gaps = 30/277 (10%) Query: 53 DAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSV 112 DA I + LT +V+ +L I G + +DLD GI V N P +V Sbjct: 42 DAEVITPFVHSRLTAEVLAQFPRLRLIATRSTGYDHIDLDYCRAHGIAVSNVPDYGDATV 101 Query: 113 AELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAES 172 AE LL + R + + RG +++ FE RGK LG++G G IG ++ + + Sbjct: 102 AEHAFALLLAVSRHIVTGAERTRRGDFSQHGLRGFELRGKTLGVLGTGRIGRRVIEIGKG 161 Query: 173 LGMYVYFYDIENKLPLGNATQVQHLSD-------LLNMSDVVSLHVPENPSTKNMMGAKE 225 GM + YD+ +A +HL LL+ +DVV+LHVP P T +++G E Sbjct: 162 FGMKIVAYDL-----FPDAAVAEHLGYEYLDLHVLLSQADVVTLHVPATPQTHHLLGDPE 216 Query: 226 ISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEP------------ATN 273 + MK G++LIN +RG VVD AL AL+++ L A +DV P EP N Sbjct: 217 FAAMKKGAVLINTARGGVVDTSALVRALSARKLRAAGLDVLPAEPLIREEAEIFRNDRRN 276 Query: 274 SDPFTSP------LCEFDNVLLTPHIGGSTQEAQENI 304 SD L F NV++TPH+ T EA I Sbjct: 277 SDTDLRALLADHVLLRFSNVIVTPHVAYDTDEALRRI 313 >UniRef50_C2BTH2 D-3-phosphoglycerate dehydrogenase n=1 Tax=Mobiluncus curtisii ATCC 43063 RepID=C2BTH2_9ACTO Length = 324 Score = 136 bits (342), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 91/276 (32%), Positives = 134/276 (48%), Gaps = 8/276 (2%) Query: 27 LRAAGYTNIEFHKGA-LDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIG 85 L +GY G LD +QL ++ RD + L + V+N L I + +G Sbjct: 27 LEESGYEVTYNQSGKPLDADQLVKAARDCVGV-LAGLDDFSTPVLNQLPDLRVISRYGVG 85 Query: 86 TNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAG 145 ++VDL A G+ V N P +N+ +VAE+ + + L R V + N RG W ++ Sbjct: 86 VDRVDLRTAGDNGVIVTNTPGANSTAVAEMALSSMFTLARHVSQLNETTRRGQWLRVVGT 145 Query: 146 SFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLLNMSD 205 E LGI+GYG IG L L L M V YD Q L++L+ S+ Sbjct: 146 --ELSQATLGIVGYGSIGRALRRLVTGLEMKVLVYDPFFDPDTDPTVQGVELAELVRESN 203 Query: 206 VVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDV 265 +SLH+P P+T+++ LM PG+ LIN SRG ++D A AL + LAG A+D Sbjct: 204 FISLHLPLTPATEHLFDDSMFRLMSPGTFLINTSRGGIIDESAAVVALEAGQLAGLALDA 263 Query: 266 FPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 + EP + L F NV+ TPH G T +++ Sbjct: 264 YEQEPPSPE----HELFRFSNVIATPHSGAQTVQSR 295 >UniRef50_Q71VT7 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=114 Tax=Bacilli RepID=Q71VT7_LISMF Length = 403 Score = 136 bits (342), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 101/341 (29%), Positives = 168/341 (49%), Gaps = 27/341 (7%) Query: 85 GTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA-----KAHRGVW 139 G N + ++ +++GI VFN P +N +V ELV+ L + R + E A V Sbjct: 67 GVNNIPVENCSEKGIVVFNTPGANANAVKELVLASLFVSARPILEGTEWVKELPAEDDVE 126 Query: 140 NKLAAGS-----FEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD----IENKLPLGN 190 K+ AG E GKKLGIIG G IG + A SLGM V YD ++ + Sbjct: 127 QKVEAGKKAFAGTELAGKKLGIIGLGAIGALVANDALSLGMDVVGYDPFVSVDTAWRISK 186 Query: 191 ATQ-VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 + + ++L D +++HVP T+ M A + L+K ++L+N SRG +VD ++ Sbjct: 187 EVERAMTIEEVLATCDYLTVHVPLTDKTRGMFNADTLQLVKDNAVLLNFSRGELVDSASV 246 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 +AL L ++ T+ AT L V + PH+G ST+EA+ N A Sbjct: 247 KEALDDGLLR-----LYITDFATKE------LLNHKKVHVFPHLGASTEEAETNCAKMAA 295 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQY 369 +L Y + GS ++VNFP V +P +G R+ H+N P ++ + + +NI Sbjct: 296 KELQSYLETGSIKNSVNFPNVEMPYNGHPRIGICHKNIPNMVGQITTELGKYSLNILDMI 355 Query: 370 LQTSAQMGYVVIDIEADEDVAEKALQA-MKAIPGTIRARLL 409 ++ + Y +IDI+ + + L++ + A+ G +R R++ Sbjct: 356 NRSKNEYAYTLIDIDKETQANLEQLKSDLLAVQGVLRVRVI 396 >UniRef50_Q1WVK4 D-3-phosphoglycerate dehydrogenase n=7 Tax=Lactobacillales RepID=Q1WVK4_LACS1 Length = 394 Score = 135 bits (341), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 113/356 (31%), Positives = 179/356 (50%), Gaps = 38/356 (10%) Query: 76 LVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAH 135 ++AI G N + L+ A +G VFN P SN +V EL+I LLL +R V A+ K Sbjct: 50 VLAIARAGAGVNNIPLEKATSQGTAVFNTPGSNANAVKELIITMLLLSVRPV-FASVK-- 106 Query: 136 RGVWNKLAAGS---------------FEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 W + AG+ E GKK+GIIG G+IG+++ LGM V Y Sbjct: 107 ---WAQKLAGADVSLQTEKGKNHFAGTELYGKKIGIIGLGNIGSRVAKACMDLGMKVIGY 163 Query: 181 D----IENKLPLGNAT-QVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLL 235 D +E L N + + L +LL SD +++H+P +N++G EI++MK ++L Sbjct: 164 DPYISVEKAWQLSNDIPRAESLEELLEQSDFITIHIPYTDKNRNIIGEDEINVMKDTAVL 223 Query: 236 INASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGG 295 +N SR +VD A+ AL +K L D F +E N +++TPH+GG Sbjct: 224 LNYSRWGIVDEDAVIKALDAKKLRLFITD-FSSEKILN----------HKQIIVTPHLGG 272 Query: 296 STQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALN 355 +T+EA+ N A L KY + G +++VN P V + RL IH+N P ++ + Sbjct: 273 TTEEAEINGAKMAANTLRKYLETGDIVNSVNLPNVEMAFDAPLRLTLIHQNVPNMVGRIT 332 Query: 356 KIFAEQGVNIAAQYLQTSAQMGYVVID-IEADEDVAEKALQAMKAIPGTIRARLLY 410 I A++ +NI ++ ++ Y +ID + E ++ + + IP IR R L+ Sbjct: 333 TILAKEEINIDNMINRSRGKIAYTMIDAADISEGKLKELKKELLEIPEVIRVRALH 388 >UniRef50_B0NEH0 Putative uncharacterized protein n=1 Tax=Clostridium scindens ATCC 35704 RepID=B0NEH0_EUBSP Length = 316 Score = 135 bits (341), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 87/264 (32%), Positives = 136/264 (51%), Gaps = 12/264 (4%) Query: 45 EQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNA 104 E LK+ DA L +TE V+N +KL+ IG +D++A K +PV Sbjct: 43 EVLKKEQPDALITEL---DRVTEKVLNGYDKLIFIGDCRANPANIDVEACKKANVPVLCT 99 Query: 105 PFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSF-----EARGKKLGIIGY 159 P N ++VAE++ G L+ +R + A G W + + E GKK+G +G+ Sbjct: 100 PARNAQAVAEMLSGLLVSYMRNLVPAVQWIKDGKWVEGTTPYYTWMGNELCGKKVGFVGF 159 Query: 160 GHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKN 219 G +G + E+ G + FYD + ++ + L ++ SD+VS+H+P STK Sbjct: 160 GAVGKHAAKILEAYGCEISFYDPFVDF-VKDSYKKCELEEIFENSDIVSIHLPVLDSTKG 218 Query: 220 MMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTS 279 M+ A+ + MK ++ +N +R VVD PAL +AL +K + GA +DV EP T Sbjct: 219 MINAELFARMKETAIFVNTARSAVVDKPALMEALKTKKIRGAILDVLEVEPPTEE---AL 275 Query: 280 PLCEFDNVLLTPHIGGSTQEAQEN 303 + DNVLLTPHI G+T E ++ Sbjct: 276 EIARLDNVLLTPHICGATYEVTDH 299 >UniRef50_B2Q5T3 Putative uncharacterized protein n=2 Tax=cellular organisms RepID=B2Q5T3_PROST Length = 331 Score = 135 bits (341), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 82/242 (33%), Positives = 123/242 (50%), Gaps = 16/242 (6%) Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 VI+ KL IG G ++ + A +GI V N P N RSVAE +G +L R + Sbjct: 85 VIDKLPKLKYIGVLRGGIENINKEYAENKGIKVMNTPGRNARSVAEFTVGMMLAETRNI- 143 Query: 129 EANAKAHRGVWNKLAAGSF-------EARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD 181 A+AH + +K F E GK +G++G+GHI + + V FYD Sbjct: 144 ---ARAHDALKDKYWRKDFVNADVIPEIGGKTIGLVGFGHIAQLVAKFLKGFDTNVIFYD 200 Query: 182 IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 + + T+V L DL+ ++D++SLH +P T+N++ K LMKP ++++N +R Sbjct: 201 -KYVDAVDGYTKVDSLEDLVKVADIISLHARLSPETQNLINEKHFKLMKPTAVIVNTARS 259 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 +++ L AL K + GAAID F EP F DNV +TPH+ GST +A Sbjct: 260 GLINERDLLQALKEKRIMGAAIDTFDDEPLKEESEFYL----LDNVTITPHMAGSTLDAF 315 Query: 302 EN 303 N Sbjct: 316 SN 317 >UniRef50_B3V649 Glyoxylate reductase n=1 Tax=uncultured marine crenarchaeote KM3-153-F8 RepID=B3V649_9ARCH Length = 336 Score = 135 bits (341), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 96/270 (35%), Positives = 139/270 (51%), Gaps = 15/270 (5%) Query: 45 EQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNA 104 +QL E D I ++ D I + L I F +G + +D+ A K+GI V N Sbjct: 42 KQLFEYSHDIDGIICSHSDNIDYDFIASCNNLKVISTFSVGYDHIDVKTATKQGIYVTNT 101 Query: 105 PFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSF----EARGKKLGIIGYG 160 P T + A+L + LL L R + E+ W A +F E K LGIIG+G Sbjct: 102 PDVLTDATADLTLALLLNLTRRINESQKIMENKEWLNAGAPNFLLGTELNNKTLGIIGFG 161 Query: 161 HIGTQLGILAESLGMYVYF-----YDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENP 215 IG + A+S GM + + +D+ +L A ++L +LL SDV+S+HV N Sbjct: 162 RIGMAVSKRAQSFGMNIVYNNRTRFDVAKELKYNIA--YKNLDELLKTSDVISVHVNLNK 219 Query: 216 STKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSD 275 ST N + +++SL+K S LIN SRG V+D +L L+ ++GAA+DVF EP Sbjct: 220 STLNFLNYEKLSLLKRDSYLINTSRGQVIDEKSLIKILSENKISGAALDVFENEPI---- 275 Query: 276 PFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 F L F NV+LTPHIG +T A+ +G Sbjct: 276 HFDHELFNFKNVILTPHIGSATVTARSKMG 305 >UniRef50_A9A5A9 Glyoxylate reductase n=2 Tax=Thaumarchaeota RepID=A9A5A9_NITMS Length = 322 Score = 135 bits (341), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 102/324 (31%), Positives = 152/324 (46%), Gaps = 27/324 (8%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALD--DEQLKESIRDAHFIGLRSRTHLTEDV 69 K L +H AL+ L+ IE HKG + +L+ I+D + + ++ Sbjct: 4 KVFLTRTLHDFALKELKKK--YQIEVHKGKIPVPQSKLRSKIKDVDGLICFPYDIINKET 61 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I+ AE L I + +G + +D A + I V P T + A+L LL LR V E Sbjct: 62 IDLAENLKVISTYSVGFDHIDTKYAKGKKIRVGYTPEVLTDATADLAFSLLLDSLRRVSE 121 Query: 130 ANAKAHRGVWNKLAAGS-----FEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 + G W K+ G+ + +GK +GI+G G IG L A++ M + +++ N Sbjct: 122 GDRIIRDGKW-KMIYGAHDYVGVDLQGKTIGILGLGRIGQTLAKRAKAFDMDIIYHN-RN 179 Query: 185 KLPLGNATQVQ----HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 +L + L++ SDV+S+HVP T M K MK + LIN SR Sbjct: 180 RLSKTKERTLDAKYVSFERLISQSDVISIHVPHTKETDKMFNMKIFKKMKNTAFLINTSR 239 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G VV+ L AL K +AGA +DVF EP + + PL + NV+L PHIG ST+E Sbjct: 240 GKVVNEKDLVTALKKKIIAGAGLDVFEQEPISKN----HPLTKLQNVVLAPHIGSSTKET 295 Query: 301 Q--------ENIGLEVAGKLIKYS 316 + N+ L + GK YS Sbjct: 296 RAKMAEITVRNLNLGMNGKKPIYS 319 >UniRef50_A8R8D3 Putative uncharacterized protein n=2 Tax=unclassified Erysipelotrichaceae RepID=A8R8D3_9FIRM Length = 310 Score = 135 bits (341), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 97/288 (33%), Positives = 141/288 (48%), Gaps = 17/288 (5%) Query: 21 QKALESLRAAGYTNIEFHKG----ALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKL 76 QK +E +R AG +E H A E+ K+ +DA I + L +++ L Sbjct: 15 QKEIERMRNAG---LEVHYNDTGLAYTHEEFKKLGKDADAI-IVGVDCLDAKMMSDCPNL 70 Query: 77 VAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHR 136 + F +GT+ ++LD A I + N+RSVAE V+ + + + A + Sbjct: 71 KVVCKFGVGTDNINLDYAKAHNIYIGRCVGGNSRSVAEHVVALMFAEAKNLYYAINEVKD 130 Query: 137 GVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD---IENKLPLGNATQ 193 W K E GK+LGIIG+G IG L A +GM +Y YD I + + + Sbjct: 131 HKWTK--PTGLEIYGKRLGIIGFGMIGKYLADYANGMGMDIYAYDAFPISKEEAQKHHVK 188 Query: 194 VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDAL 253 V L ++ D +SLHVP STKNM+ KE MK + +INA+RG VVD AL +AL Sbjct: 189 VASLDEIYAECDYISLHVPLLDSTKNMISTKEFKSMKNSACIINAARGGVVDEEALYEAL 248 Query: 254 ASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 + + A DV+ +EP +D L +N LTPH TQEA+ Sbjct: 249 TTGEIRSACFDVYSSEPPKEND----KLLALENFYLTPHTAARTQEAE 292 >UniRef50_C0WBB3 D-isomer specific 2-hydroxyacid dehydrogenase n=1 Tax=Acidaminococcus sp. D21 RepID=C0WBB3_9FIRM Length = 318 Score = 135 bits (340), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 104/322 (32%), Positives = 155/322 (48%), Gaps = 13/322 (4%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + + A L GY +E D+E +K++I D + R+ + T VI Sbjct: 3 KILIPKALKESARTFLTDKGYELVELQ--GTDEETMKKAISDVDAVIARTEKY-TPAVIK 59 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AA L I + IG ++L+A K+G+ V A NT SVAE I +L LR + + + Sbjct: 60 AARNLKIIARYGIGYENINLEACDKKGVTVTLARGCNTYSVAEHAITLMLAALRQISQLD 119 Query: 132 AKAHRGVW-NKLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDI---ENKL 186 + +G W ++ + EARGK G IG G IG + +A M + YD ++K Sbjct: 120 REVRKGDWKSRDRVETHEARGKVFGSIGIGPIGMEAVKIAHFGFQMKILVYDKFVDQSKF 179 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 P L DL+ SDVVS H+P N T +++ + IS MK G +L+N SRG + D Sbjct: 180 P-DWIEFTNTLDDLMERSDVVSPHLPLNKGTFHILNEESISHMKRGGILLNVSRGAIWDE 238 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 A+ AL + AA DVF TEP T + PL N + TPH ++EA + + Sbjct: 239 KAVYQALQEGRIGAAAGDVFETEPPTPDN----PLFALPNFIGTPHTAALSEEAVTAVAM 294 Query: 307 EVAGKLIKYSDNGSTLSAVNFP 328 A + L +N P Sbjct: 295 NCAHAIDDLFSGKEPLYIINHP 316 >UniRef50_C6PA05 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Thermoanaerobacterales RepID=C6PA05_CLOTS Length = 355 Score = 135 bits (340), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 99/295 (33%), Positives = 154/295 (52%), Gaps = 15/295 (5%) Query: 24 LESLRAAGYTNIEFHKGA-LDDEQLKESIRDAH--FIGLRSRTHLTEDVINAAEKLVAIG 80 E L+ Y I G ++++LKE I+D +GL +TEDV+ A+KL I Sbjct: 55 FEMLKKYDYEIIRNETGKPYEEDELKELIKDVDGVIVGL---DKITEDVLKNAKKLKVIT 111 Query: 81 CFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWN 140 + +G + +D++ A K GI V P +N SVA+L +L L R + + + WN Sbjct: 112 KYGVGLDNIDINYAEKLGIKVTYTPGANKESVADLAFTMMLGLSRDIIKLDKIVRNNQWN 171 Query: 141 KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSD- 199 K+ E GK +GIIG G IG + A M + YD + ++++ Sbjct: 172 KIIGC--EIYGKTIGIIGTGSIGKCVAKRATGFDMEILAYDKYPDYDFADKIGMKYVDKK 229 Query: 200 -LLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHL 258 LL SD ++LHVP + + +E+++MK + +IN SRG +++ AL AL SK + Sbjct: 230 TLLEKSDFITLHVPLTDEMYHFIDEEELNMMKDTAYIINTSRGGIINENALYSALKSKKI 289 Query: 259 AGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLI 313 AGAA+D F TEP P + L E DN++L+PH G ST++A + +G+ LI Sbjct: 290 AGAALDAFETEP-----PLNNKLLELDNIILSPHCGASTKDATDRMGIMAVEGLI 339 >UniRef50_D1NAT8 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1NAT8_9BACT Length = 316 Score = 135 bits (340), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 98/258 (37%), Positives = 135/258 (52%), Gaps = 8/258 (3%) Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 ++ +A K I F IG + ++L AA++GI N P + +SVAE IG +LL R Sbjct: 58 ELYDAVPKGGVIARFGIGCDNINLPRAAEKGIYCTNTPGALEQSVAECAIGMILLAARQF 117 Query: 128 PEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAES-LGMYVYFYDIENKL 186 A G+W E GK L +IG G IG+++ +A++ GM V Sbjct: 118 IAAADDCRNGLWQPQTG--CELAGKTLAVIGCGAIGSRVAAIAKNGFGMSVTGVIRSAPR 175 Query: 187 PLGNATQ-VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 P A + V++ SD + +D VSLH+P +P N + A + MKPGS LIN +RG+VVD Sbjct: 176 PDCPADRFVKNWSDAVADADFVSLHIPGSPENLNYVSAGRLKQMKPGSWLINTARGSVVD 235 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL DAL S + GA DVF EP P L N+++TPHIG ST+EA I Sbjct: 236 EAALYDALLSGRIGGAVSDVFRQEPYA---PSGKDLRTLPNMIMTPHIGSSTREACRRIA 292 Query: 306 LEVAGKLIKYSDNGSTLS 323 L A K I+ + G LS Sbjct: 293 L-AALKNIRLCELGDPLS 309 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_P43885 D-3-phosphoglycerate dehydrogenase n=399 Tax=Bac... 551 e-155 UniRef50_A1W4D0 D-3-phosphoglycerate dehydrogenase n=26 Tax=cell... 520 e-146 UniRef50_C6W4R7 HAD-superfamily hydrolase, subfamily IB (PSPase-... 502 e-140 UniRef50_P40054 D-3-phosphoglycerate dehydrogenase 1 n=76 Tax=ce... 494 e-138 UniRef50_A9EWF7 Phosphoglycerate dehydrogenase n=17 Tax=cellular... 492 e-137 UniRef50_D2VJX3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Naegl... 491 e-137 UniRef50_C5DTI9 ZYRO0C08932p n=1 Tax=Zygosaccharomyces rouxii Re... 490 e-137 UniRef50_Q11WE3 Phosphoserine phosphatase and phosphoglycerate d... 486 e-136 UniRef50_Q1CYP3 D-3-phosphoglycerate dehydrogenase n=5 Tax=cellu... 472 e-131 UniRef50_A3UGW9 D-3-phosphoglycerate dehydrogenase n=2 Tax=Alpha... 469 e-131 UniRef50_D0NEX4 D-3-phosphoglycerate dehydrogenase n=1 Tax=Phyto... 459 e-128 UniRef50_C7R3H8 D-isomer specific 2-hydroxyacid dehydrogenase NA... 459 e-128 UniRef50_D2RHI0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Archa... 450 e-125 UniRef50_C6HZG9 D-3-phosphoglycerate dehydrogenase n=1 Tax=Lepto... 445 e-123 UniRef50_C8WVY8 D-3-phosphoglycerate dehydrogenase n=2 Tax=Alicy... 443 e-123 UniRef50_A5D6D4 Phosphoglycerate dehydrogenase and related dehyd... 438 e-121 UniRef50_O29445 D-3-phosphoglycerate dehydrogenase n=8 Tax=cellu... 438 e-121 UniRef50_B8HPZ0 D-3-phosphoglycerate dehydrogenase n=26 Tax=cell... 438 e-121 UniRef50_C2BW43 Phosphoglycerate dehydrogenase n=1 Tax=Mobiluncu... 436 e-121 UniRef50_Q1AXS3 D-3-phosphoglycerate dehydrogenase n=2 Tax=Actin... 435 e-120 UniRef50_O27051 D-3-phosphoglycerate dehydrogenase n=16 Tax=Arch... 435 e-120 UniRef50_B4D991 D-3-phosphoglycerate dehydrogenase n=3 Tax=Verru... 431 e-119 UniRef50_A6UQN3 D-3-phosphoglycerate dehydrogenase n=4 Tax=Eurya... 427 e-118 UniRef50_A6G5P3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Plesi... 427 e-118 UniRef50_A0LMX1 D-3-phosphoglycerate dehydrogenase n=1 Tax=Syntr... 426 e-118 UniRef50_A3DM01 D-isomer specific 2-hydroxyacid dehydrogenase, N... 426 e-118 UniRef50_B0TAQ8 D-3-phosphoglycerate dehydrogenase n=4 Tax=Clost... 425 e-117 UniRef50_A5G1V9 D-3-phosphoglycerate dehydrogenase n=3 Tax=Prote... 424 e-117 UniRef50_Q2G4V7 D-3-phosphoglycerate dehydrogenase n=146 Tax=cel... 424 e-117 UniRef50_A9WCW3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chlor... 420 e-116 UniRef50_Q6A895 D-3-phosphoglycerate dehydrogenase n=4 Tax=Actin... 420 e-116 UniRef50_A1RYE4 Glyoxylate reductase n=18 Tax=cellular organisms... 419 e-116 UniRef50_P35136 D-3-phosphoglycerate dehydrogenase n=12 Tax=Baci... 418 e-115 UniRef50_A7IAB7 D-3-phosphoglycerate dehydrogenase n=11 Tax=cell... 418 e-115 UniRef50_A2STQ1 D-3-phosphoglycerate dehydrogenase n=5 Tax=cellu... 418 e-115 UniRef50_A5FRL7 D-3-phosphoglycerate dehydrogenase n=5 Tax=Dehal... 418 e-115 UniRef50_UPI0001C41AB7 phosphoglycerate dehydrogenase SerA n=1 T... 417 e-115 UniRef50_D1JIG3 D-3-phosphoglycerate dehydrogenase n=1 Tax=uncul... 416 e-115 UniRef50_B3DVF6 Phosphoglycerate dehydrogenase and ACT domains n... 416 e-115 UniRef50_B8CX87 D-3-phosphoglycerate dehydrogenase n=1 Tax=Halot... 416 e-115 UniRef50_Q1IVI0 D-3-phosphoglycerate dehydrogenase n=3 Tax=Acido... 414 e-114 UniRef50_B9L167 Phosphoglycerate dehydrogenase SerA n=2 Tax=Ther... 413 e-114 UniRef50_Q67TJ9 Phosphoglycerate dehydrogenase n=1 Tax=Symbiobac... 413 e-114 UniRef50_O43175 D-3-phosphoglycerate dehydrogenase n=53 Tax=Bila... 412 e-113 UniRef50_D1FX73 3-phosphoglycerate dehydrogenase-like protein n=... 412 e-113 UniRef50_P73821 D-3-phosphoglycerate dehydrogenase n=40 Tax=Cyan... 412 e-113 UniRef50_B2V7I1 D-3-phosphoglycerate dehydrogenase n=8 Tax=Aquif... 411 e-113 UniRef50_UPI0001C430A3 D-3-phosphoglycerate dehydrogenase n=1 Ta... 409 e-113 UniRef50_B7KZ64 D-3-phosphoglycerate dehydrogenase n=16 Tax=cell... 409 e-112 UniRef50_A8ZXY9 D-3-phosphoglycerate dehydrogenase n=6 Tax=Delta... 408 e-112 UniRef50_B3RTC6 Putative uncharacterized protein n=1 Tax=Trichop... 408 e-112 UniRef50_Q4L766 D-3-phosphoglycerate dehydrogenase n=3 Tax=Staph... 408 e-112 UniRef50_C4V410 Phosphoglycerate dehydrogenase n=4 Tax=Veillonel... 407 e-112 UniRef50_Q49YF7 D-3-phosphoglycerate dehydrogenase n=55 Tax=Baci... 407 e-112 UniRef50_C0QYX0 D-3-phosphoglycerate dehydrogenase n=2 Tax=Brach... 407 e-112 UniRef50_A7HDB1 D-3-phosphoglycerate dehydrogenase n=3 Tax=Prote... 406 e-112 UniRef50_C6PIV3 D-isomer specific 2-hydroxyacid dehydrogenase NA... 406 e-112 UniRef50_B5JEX5 D-3-phosphoglycerate dehydrogenase n=2 Tax=Verru... 406 e-112 UniRef50_A6C9V4 Phosphoglycerate dehydrogenase n=1 Tax=Planctomy... 405 e-111 UniRef50_B2IJN8 D-3-phosphoglycerate dehydrogenase n=6 Tax=Bacte... 405 e-111 UniRef50_B1HVJ4 Phosphoglycerate dehydrogenase n=5 Tax=Bacillale... 405 e-111 UniRef50_Q1PZY1 Similar to D-3-phosphoglycerate dehydrogenase (P... 404 e-111 UniRef50_UPI0001C31769 D-3-phosphoglycerate dehydrogenase n=1 Ta... 403 e-111 UniRef50_Q5WGX7 D-3-phosphoglycerate dehydrogenase n=8 Tax=Bacil... 401 e-110 UniRef50_A7HM61 Glyoxylate reductase n=6 Tax=cellular organisms ... 401 e-110 UniRef50_C1ZMC1 D-3-phosphoglycerate dehydrogenase n=2 Tax=Planc... 401 e-110 UniRef50_B6YWH0 Glyoxylate reductase n=95 Tax=cellular organisms... 400 e-110 UniRef50_A5IMH3 D-isomer specific 2-hydroxyacid dehydrogenase, N... 399 e-109 UniRef50_B7P3M8 D-3-phosphoglycerate dehydrogenase, putative (Fr... 398 e-109 UniRef50_A5GES6 D-3-phosphoglycerate dehydrogenase n=12 Tax=Desu... 398 e-109 UniRef50_B6KF90 D-3-phosphoglycerate dehydrogenase, putative n=3... 397 e-109 UniRef50_O04130 D-3-phosphoglycerate dehydrogenase, chloroplasti... 395 e-108 UniRef50_B0K2Z0 D-isomer specific 2-hydroxyacid dehydrogenase, N... 395 e-108 UniRef50_C9LMC8 Phosphoglycerate dehydrogenase n=1 Tax=Dialister... 394 e-108 UniRef50_B6H0R3 Pc12g10550 protein n=23 Tax=Fungi/Metazoa group ... 394 e-108 UniRef50_C1TPS0 Lactate dehydrogenase-like oxidoreductase n=1 Ta... 393 e-108 UniRef50_D2RMS7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acida... 393 e-108 UniRef50_Q5HNI1 D-3-phosphoglycerate dehydrogenase n=73 Tax=Stap... 393 e-108 UniRef50_C1SGT4 D-3-phosphoglycerate dehydrogenase n=1 Tax=Denit... 392 e-107 UniRef50_Q7UQL2 Phosphoglycerate dehydrogenase n=1 Tax=Rhodopire... 391 e-107 UniRef50_D2R855 D-3-phosphoglycerate dehydrogenase n=1 Tax=Pirel... 391 e-107 UniRef50_A8A9G4 D-isomer specific 2-hydroxyacid dehydrogenase, N... 390 e-107 UniRef50_B5YAK7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Dicty... 388 e-106 UniRef50_UPI0000DB72A4 PREDICTED: similar to 3-phosphoglycerate ... 387 e-106 UniRef50_Q0B0Y6 D-3-phosphoglycerate dehydrogenase n=9 Tax=Bacte... 387 e-106 UniRef50_Q3AQU0 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chlor... 387 e-106 UniRef50_Q5SZU1 Phosphoglycerate dehydrogenase n=11 Tax=Eutheria... 387 e-106 UniRef50_D0MG73 Glyoxylate reductase n=1 Tax=Rhodothermus marinu... 387 e-106 UniRef50_C0GLG9 D-isomer specific 2-hydroxyacid dehydrogenase NA... 384 e-105 UniRef50_D2C7W6 D-isomer specific 2-hydroxyacid dehydrogenase NA... 383 e-105 UniRef50_C8WI96 D-3-phosphoglycerate dehydrogenase n=1 Tax=Egger... 383 e-105 UniRef50_C0WBM0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acida... 383 e-105 UniRef50_B1KZ88 D-isomer specific 2-hydroxyacid dehydrogenase fa... 383 e-105 UniRef50_A7GQE1 D-isomer specific 2-hydroxyacid dehydrogenase NA... 382 e-104 UniRef50_B9L1V2 Glyoxylate reductase n=2 Tax=Thermomicrobia (cla... 382 e-104 UniRef50_B7CA05 Putative uncharacterized protein n=1 Tax=Eubacte... 381 e-104 UniRef50_Q2RH37 D-isomer specific 2-hydroxyacid dehydrogenase, N... 381 e-104 UniRef50_A6CKS4 Putative uncharacterized protein n=2 Tax=Bacilla... 381 e-104 UniRef50_A7SFV8 Predicted protein (Fragment) n=1 Tax=Nematostell... 380 e-104 UniRef50_Q18DJ4 Phosphoglycerate dehydrogenase n=13 Tax=Halobact... 380 e-104 UniRef50_UPI00016C495D phosphoglycerate dehydrogenase n=1 Tax=Ge... 380 e-104 UniRef50_Q4WHR3 D-3-phosphoglycerate dehydrogenase n=3 Tax=Eurot... 379 e-103 UniRef50_A5IK90 D-isomer specific 2-hydroxyacid dehydrogenase, N... 378 e-103 UniRef50_B3T9W6 Putative D-isomer specific 2-hydroxyacid dehydro... 378 e-103 UniRef50_C2HP35 Glyoxylate reductase n=10 Tax=Lactobacillus RepI... 377 e-103 UniRef50_A1HQU2 Glyoxylate reductase n=1 Tax=Thermosinus carboxy... 375 e-102 UniRef50_D0MDQ9 D-isomer specific 2-hydroxyacid dehydrogenase NA... 373 e-102 UniRef50_C2D1B3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Lacto... 372 e-101 UniRef50_B0TB58 Glyoxylate reductase n=7 Tax=cellular organisms ... 372 e-101 UniRef50_D1YY17 Glycerate dehydrogenase n=1 Tax=Methanocella pal... 371 e-101 UniRef50_Q1J0H2 D-3-phosphoglycerate dehydrogenase n=8 Tax=Deino... 370 e-101 UniRef50_C4DLZ3 Lactate dehydrogenase-like oxidoreductase n=1 Ta... 370 e-101 UniRef50_C9MSC4 Glycerate dehydrogenase n=3 Tax=Prevotella RepID... 370 e-101 UniRef50_B4AUS0 Glyoxylate reductase n=1 Tax=Cyanothece sp. PCC ... 370 e-101 UniRef50_Q46AE6 Glycerate dehydrogenase n=2 Tax=Methanosarcina R... 368 e-100 UniRef50_A1HSQ7 D-isomer specific 2-hydroxyacid dehydrogenase, N... 368 e-100 UniRef50_A6C2G1 Phosphoglycerate dehydrogenase (SerA) n=1 Tax=Pl... 368 e-100 UniRef50_B8I0H1 D-3-phosphoglycerate dehydrogenase n=13 Tax=Clos... 368 e-100 UniRef50_UPI0001BC4ADC hypothetical protein FulcA4_06865 n=1 Tax... 367 e-100 UniRef50_D1U9G1 D-isomer specific 2-hydroxyacid dehydrogenase NA... 367 e-100 UniRef50_A9KPU0 D-isomer specific 2-hydroxyacid dehydrogenase NA... 366 e-100 UniRef50_C5EL38 D-3-phosphoglycerate dehydrogenase n=1 Tax=Clost... 365 2e-99 UniRef50_Q1K3M3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Desul... 363 5e-99 UniRef50_UPI0001972FE9 D-isomer specific 2-hydroxyacid dehydroge... 362 2e-98 UniRef50_D1C3Y3 D-isomer specific 2-hydroxyacid dehydrogenase NA... 361 3e-98 UniRef50_Q3SK87 D-isomer specific 2-hydroxyacid dehydrogenase n=... 360 4e-98 UniRef50_B0KD78 D-isomer specific 2-hydroxyacid dehydrogenase, N... 360 4e-98 UniRef50_C0CRA6 Putative uncharacterized protein n=2 Tax=Clostri... 360 5e-98 UniRef50_A5W066 D-isomer specific 2-hydroxyacid dehydrogenase, N... 359 1e-97 UniRef50_A9A1H5 D-isomer specific 2-hydroxyacid dehydrogenase NA... 358 2e-97 UniRef50_A9BJ57 D-isomer specific 2-hydroxyacid dehydrogenase NA... 358 2e-97 UniRef50_D1VVP3 Phosphoglycerate dehydrogenase n=1 Tax=Peptoniph... 358 3e-97 UniRef50_B0NG91 Putative uncharacterized protein n=1 Tax=Clostri... 358 3e-97 UniRef50_C4XIX3 Putative D-isomer specific 2-hydroxyacid dehydro... 358 3e-97 UniRef50_Q71VT7 D-isomer specific 2-hydroxyacid dehydrogenase fa... 357 4e-97 UniRef50_A1HMI9 Phosphoglycerate dehydrogenase n=1 Tax=Thermosin... 357 5e-97 UniRef50_A9A5A9 Glyoxylate reductase n=2 Tax=Thaumarchaeota RepI... 357 5e-97 UniRef50_Q0W672 Glycerate dehydrogenase n=2 Tax=Archaea RepID=Q0... 357 7e-97 UniRef50_A7VV70 Putative uncharacterized protein n=1 Tax=Clostri... 356 9e-97 UniRef50_A7NS02 Glyoxylate reductase n=8 Tax=Bacteria RepID=A7NS... 355 1e-96 UniRef50_B8FRV3 D-isomer specific 2-hydroxyacid dehydrogenase NA... 354 3e-96 UniRef50_C4ZHF5 Phosphoglycerate dehydrogenase, putative n=3 Tax... 354 3e-96 UniRef50_O32264 Probable 2-ketogluconate reductase n=7 Tax=Bacil... 353 7e-96 UniRef50_B0PD17 Putative uncharacterized protein n=1 Tax=Anaerot... 353 8e-96 UniRef50_UPI000197AFFA hypothetical protein BACCOPRO_00987 n=1 T... 353 8e-96 UniRef50_C1A4S7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Gemma... 352 2e-95 UniRef50_Q7WEA3 Phosphoglycerate dehydrogenase n=1 Tax=Bordetell... 351 2e-95 UniRef50_A0Q365 D-isomer specific 2-hydroxyacid dehydrogenases n... 351 3e-95 UniRef50_A5N5A9 SerA n=3 Tax=Clostridium RepID=A5N5A9_CLOK5 351 3e-95 UniRef50_Q04AA8 Lactate dehydrogenase related enzyme n=3 Tax=Fir... 351 3e-95 UniRef50_A6Q7Q2 D-3-phosphoglycerate dehydrogenase n=49 Tax=Epsi... 350 5e-95 UniRef50_B2I1D3 Phosphoglycerate dehydrogenase n=2 Tax=Acinetoba... 350 5e-95 UniRef50_Q0AFR7 D-3-phosphoglycerate dehydrogenase n=22 Tax=Bact... 349 9e-95 UniRef50_C2HJZ3 Possible glyoxylate reductase n=2 Tax=Finegoldia... 349 9e-95 UniRef50_A1RDF9 D-isomer specific 2-hydroxyacid dehydrogenase fa... 349 1e-94 UniRef50_D2RN56 D-isomer specific 2-hydroxyacid dehydrogenase NA... 349 1e-94 UniRef50_C7H045 D-isomer specific 2-hydroxyacid dehydrogenase fa... 349 1e-94 UniRef50_C6PA05 D-isomer specific 2-hydroxyacid dehydrogenase NA... 348 2e-94 UniRef50_B6G9P0 Putative uncharacterized protein n=3 Tax=Bacteri... 348 2e-94 UniRef50_Q5WLJ2 D-3-phosphoglycerate dehydrogenase n=7 Tax=Bacte... 348 2e-94 UniRef50_Q031D4 D-3-phosphoglycerate dehydrogenase n=9 Tax=Strep... 347 4e-94 UniRef50_B1R2D5 Glycerate dehydrogenase n=6 Tax=Clostridiales Re... 347 4e-94 UniRef50_A0LN07 D-isomer specific 2-hydroxyacid dehydrogenase, N... 347 5e-94 UniRef50_C0BYY9 Putative uncharacterized protein n=1 Tax=Clostri... 346 7e-94 UniRef50_B2T8V2 D-isomer specific 2-hydroxyacid dehydrogenase NA... 346 8e-94 UniRef50_D1W6S1 4-phosphoerythronate dehydrogenase n=4 Tax=Prevo... 346 9e-94 UniRef50_C3XIZ9 D-3-phosphoglycerate dehydrogenase n=4 Tax=Campy... 346 9e-94 UniRef50_UPI00016C0F1F D-isomer specific 2-hydroxyacid dehydroge... 346 1e-93 UniRef50_UPI000038E3F5 glyoxylate reductase n=1 Tax=Ferroplasma ... 345 1e-93 UniRef50_Q6F7L0 Glycerate dehydrogenase n=3 Tax=Proteobacteria R... 345 2e-93 UniRef50_Q03YV3 Lactate dehydrogenase related enzyme n=2 Tax=Leu... 345 2e-93 UniRef50_P0A545 D-3-phosphoglycerate dehydrogenase n=57 Tax=Acti... 345 3e-93 UniRef50_B6YUM0 D-isomer specific 2-hydroxyacid dehydrogenase n=... 344 3e-93 UniRef50_B2KCL9 D-isomer specific 2-hydroxyacid dehydrogenase NA... 344 3e-93 UniRef50_O33116 D-3-phosphoglycerate dehydrogenase n=22 Tax=Acti... 344 4e-93 UniRef50_Q8ZXX8 D-3-phosphoglycerate dehydrogenase (SerA) n=1 Ta... 344 4e-93 UniRef50_C0WBB3 D-isomer specific 2-hydroxyacid dehydrogenase n=... 343 5e-93 UniRef50_A8MCX1 D-isomer specific 2-hydroxyacid dehydrogenase NA... 343 5e-93 UniRef50_A3MTB6 D-isomer specific 2-hydroxyacid dehydrogenase, N... 343 6e-93 UniRef50_A4RX85 Predicted protein n=8 Tax=cellular organisms Rep... 343 7e-93 UniRef50_D1CGN8 D-isomer specific 2-hydroxyacid dehydrogenase NA... 343 7e-93 UniRef50_UPI0001973600 D-3-phosphoglycerate dehydrogenase n=1 Ta... 342 1e-92 UniRef50_B3T034 Putative D-isomer specific 2-hydroxyacid dehydro... 342 1e-92 UniRef50_B9XQY4 D-isomer specific 2-hydroxyacid dehydrogenase NA... 342 2e-92 UniRef50_C5BMJ8 D-isomer specific 2-hydroxyacid dehydrogenase, c... 342 2e-92 UniRef50_A6ULR7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 341 2e-92 UniRef50_B0K1J9 D-isomer specific 2-hydroxyacid dehydrogenase, N... 341 3e-92 UniRef50_Q03W66 D-3-phosphoglycerate dehydrogenase n=3 Tax=Leuco... 341 3e-92 UniRef50_C6MGD3 D-isomer specific 2-hydroxyacid dehydrogenase NA... 341 4e-92 UniRef50_B0PHF7 Putative uncharacterized protein n=1 Tax=Anaerot... 340 5e-92 UniRef50_A8MD25 D-isomer specific 2-hydroxyacid dehydrogenase NA... 340 5e-92 UniRef50_Q214B1 D-isomer specific 2-hydroxyacid dehydrogenase, N... 340 5e-92 UniRef50_C0C1A5 Putative uncharacterized protein n=1 Tax=Clostri... 340 6e-92 UniRef50_Q6MN05 Phosphoglycerate dehydrogenase n=1 Tax=Bdellovib... 340 6e-92 UniRef50_A1R7L8 D-3-phosphoglycerate dehydrogenase n=35 Tax=Acti... 339 1e-91 UniRef50_C6VZ76 D-isomer specific 2-hydroxyacid dehydrogenase NA... 339 1e-91 UniRef50_B2RGZ9 D-isomer specific 2-hydroxyacid dehydrogenase fa... 339 1e-91 UniRef50_C7TNB9 D-isomer specific 2-hydroxyacid dehydrogenase, N... 338 2e-91 UniRef50_Q0ADX2 D-isomer specific 2-hydroxyacid dehydrogenase, N... 338 2e-91 UniRef50_C0C032 Putative uncharacterized protein n=2 Tax=Firmicu... 338 2e-91 UniRef50_A3CQK1 Glyoxylate reductase, NADH-dependent, putative n... 338 2e-91 UniRef50_Q3KHS7 2-ketogluconate reductase n=24 Tax=Proteobacteri... 338 2e-91 UniRef50_A4YUP8 Putative D-3-phosphoglycerate dehydrogenase (PGD... 338 2e-91 UniRef50_A1W7V5 D-isomer specific 2-hydroxyacid dehydrogenase, N... 338 3e-91 UniRef50_Q7D366 Putative phosphoglycerate dehydrogenase n=1 Tax=... 338 3e-91 UniRef50_A4YFM2 D-isomer specific 2-hydroxyacid dehydrogenase, N... 338 3e-91 UniRef50_A7VWU5 Putative uncharacterized protein n=1 Tax=Clostri... 338 3e-91 UniRef50_A4FIF2 D-3-phosphoglycerate dehydrogenase n=1 Tax=Sacch... 337 3e-91 UniRef50_A8R8D3 Putative uncharacterized protein n=2 Tax=unclass... 337 4e-91 UniRef50_Q1GAM7 D-isomer specific 2-hydroxyacid dehydrogenase n=... 337 5e-91 UniRef50_A1W9A3 D-isomer specific 2-hydroxyacid dehydrogenase, N... 337 5e-91 UniRef50_B2IKB7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 337 5e-91 UniRef50_B8J355 D-isomer specific 2-hydroxyacid dehydrogenase NA... 337 5e-91 UniRef50_Q8EMM3 Dehydrogenase n=5 Tax=Bacteria RepID=Q8EMM3_OCEIH 336 6e-91 UniRef50_C4TXE2 D-3-phosphoglycerate dehydrogenase n=3 Tax=Bacte... 336 7e-91 UniRef50_C5RAQ7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Weiss... 336 8e-91 UniRef50_A9CLC8 D-isomer specific 2-hydroxyacid dehydrogenase, N... 336 9e-91 UniRef50_B1M476 D-isomer specific 2-hydroxyacid dehydrogenase NA... 336 9e-91 UniRef50_Q160B1 Glyoxylate reductase n=24 Tax=Bacteria RepID=Q16... 336 9e-91 UniRef50_C7H518 Glycerate dehydrogenase n=3 Tax=cellular organis... 336 9e-91 UniRef50_A1AQ02 D-isomer specific 2-hydroxyacid dehydrogenase, N... 336 1e-90 UniRef50_Q04DF1 D-3-phosphoglycerate dehydrogenase n=1 Tax=Oenoc... 336 1e-90 UniRef50_B0PA81 Putative uncharacterized protein n=1 Tax=Anaerot... 336 1e-90 UniRef50_C8QAG5 D-isomer specific 2-hydroxyacid dehydrogenase NA... 335 1e-90 UniRef50_A1AR04 D-isomer specific 2-hydroxyacid dehydrogenase, N... 335 1e-90 UniRef50_A0Y9Y1 Glyoxylate reductase n=3 Tax=unclassified Gammap... 335 1e-90 UniRef50_UPI0001973D95 D-3-phosphoglycerate dehydrogenase n=1 Ta... 335 2e-90 UniRef50_D1CAH7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 335 2e-90 UniRef50_Q8EP33 Glycerate dehydrogenase n=2 Tax=Bacillaceae RepI... 335 2e-90 UniRef50_A8IH65 D-isomer specific 2-hydroxyacid dehydrogenase n=... 335 2e-90 UniRef50_Q8XPB1 D-3-phosphoglycerate dehydrogenase n=9 Tax=Clost... 335 2e-90 UniRef50_A7BQE7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Beggi... 335 2e-90 UniRef50_Q59516 Glycerate dehydrogenase n=35 Tax=Proteobacteria ... 335 2e-90 UniRef50_A4EAR0 Putative uncharacterized protein n=3 Tax=Bacteri... 335 3e-90 UniRef50_Q4PK14 Predicted D-isomer specific 2-hydroxyacid dehydr... 334 3e-90 UniRef50_C8WP48 D-isomer specific 2-hydroxyacid dehydrogenase NA... 334 4e-90 UniRef50_Q01ZI8 D-isomer specific 2-hydroxyacid dehydrogenase, N... 334 4e-90 UniRef50_C4V5E1 D-isomer specific 2-hydroxyacid dehydrogenase, N... 334 4e-90 UniRef50_C6PW23 D-isomer specific 2-hydroxyacid dehydrogenase NA... 334 4e-90 UniRef50_Q65WI5 SerA protein n=1 Tax=Mannheimia succiniciproduce... 334 5e-90 UniRef50_Q5WAF3 2-ketogluconate reductase n=2 Tax=Bacteria RepID... 334 5e-90 UniRef50_Q1MPI0 Lactate dehydrogenase and related dehydrogenases... 333 5e-90 UniRef50_C2BTH2 D-3-phosphoglycerate dehydrogenase n=1 Tax=Mobil... 333 6e-90 UniRef50_A7NGZ0 D-isomer specific 2-hydroxyacid dehydrogenase NA... 333 6e-90 UniRef50_Q03WU1 Lactate dehydrogenase related dehydrogenase n=3 ... 333 7e-90 UniRef50_C3WAJ0 D-isomer specific 2-hydroxyacid dehydrogenase n=... 333 8e-90 Sequences not found previously or not previously below threshold: UniRef50_B0P693 Putative uncharacterized protein n=2 Tax=Clostri... 344 4e-93 UniRef50_B1ZP48 D-isomer specific 2-hydroxyacid dehydrogenase NA... 341 2e-92 UniRef50_C5PUM3 Glyoxylate reductase n=2 Tax=Sphingobacterium sp... 336 1e-90 UniRef50_B8FRA5 D-isomer specific 2-hydroxyacid dehydrogenase NA... 335 2e-90 >UniRef50_P43885 D-3-phosphoglycerate dehydrogenase n=399 Tax=Bacteria RepID=SERA_HAEIN Length = 410 Score = 551 bits (1421), Expect = e-155, Method: Composition-based stats. Identities = 290/409 (70%), Positives = 341/409 (83%), Gaps = 3/409 (0%) Query: 3 KVSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSR 62 KVSL+K KIKF+L EGVHQ AL++L AAGYTNI+++K ALD ++LKE+I+D HFIGLRSR Sbjct: 4 KVSLDKSKIKFVLFEGVHQSALDTLHAAGYTNIDYYKKALDGDELKEAIKDVHFIGLRSR 63 Query: 63 THLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLL 122 THLT ++I AA KL+A+GCFCIGTNQVDL+AA RGIPVFNAPFSNTRSVAELV+GE+LL Sbjct: 64 THLTAEMIEAAPKLIAVGCFCIGTNQVDLNAAKARGIPVFNAPFSNTRSVAELVLGEILL 123 Query: 123 LLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI 182 L+R VP+ANA+ HRGVWNK A GS E RGKKLGIIGYGHIG+QL I+AESLGM VYFYDI Sbjct: 124 LMRNVPQANAEVHRGVWNKSATGSHEVRGKKLGIIGYGHIGSQLSIIAESLGMDVYFYDI 183 Query: 183 ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 ENKLPLGNA QV+ L +LL+ DVVSLHVPE PSTKN+M I+ +K G++LINA+RGT Sbjct: 184 ENKLPLGNAKQVRSLEELLSSCDVVSLHVPELPSTKNLMNVARIAQLKQGAILINAARGT 243 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 VVDI AL AL L GAAIDVFP EPA+ ++ F SPL EFDNV+LTPHIGGST EAQE Sbjct: 244 VVDIDALAQALKDGKLQGAAIDVFPVEPASINEEFISPLREFDNVILTPHIGGSTAEAQE 303 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLH-GGRRLMHIHENRPGVLTALNKIFAEQ 361 NIG EVAGK +KYSDNGSTLS+VNFPEVSLP H G +RL+HIHENRPG+L LN+IF E Sbjct: 304 NIGFEVAGKFVKYSDNGSTLSSVNFPEVSLPEHEGTKRLLHIHENRPGILNKLNQIFVEA 363 Query: 362 GVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY 410 +NIAAQYLQT ++GYVV+D+E ++ A L +K I GTIRAR+LY Sbjct: 364 NLNIAAQYLQTDPKIGYVVVDVETND--ASPLLTKLKEIDGTIRARVLY 410 >UniRef50_A1W4D0 D-3-phosphoglycerate dehydrogenase n=26 Tax=cellular organisms RepID=A1W4D0_ACISJ Length = 434 Score = 520 bits (1340), Expect = e-146, Method: Composition-based stats. Identities = 260/411 (63%), Positives = 320/411 (77%), Gaps = 3/411 (0%) Query: 1 MAKVSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLR 60 MAK SL+K KIKFLL+EG+H A+E LR+AGYT +E GAL+ E+L+ I D HFIG+R Sbjct: 26 MAKTSLDKSKIKFLLLEGIHPSAVEVLRSAGYTQVEVLAGALEGEELRRKIADVHFIGIR 85 Query: 61 SRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGEL 120 SRT LT DV A KLVA+GCFCIGTNQVDL+AA +RGI VFNAP+SNTRSVAELV+ E Sbjct: 86 SRTQLTADVFAHAHKLVAVGCFCIGTNQVDLNAARERGIAVFNAPYSNTRSVAELVLAEA 145 Query: 121 LLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 +LLLRGVPE NA AHRG W K A ++E RGK LGI+GYG IGTQL +LAE+LGM+V F+ Sbjct: 146 ILLLRGVPEKNAAAHRGGWLKSATNAYEIRGKTLGIVGYGSIGTQLSVLAEALGMHVIFH 205 Query: 181 DIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 D+ +KLPLGNA QV L +LL +D+V+LHVPE PST+ M+GA EI+ MKPG +LINASR Sbjct: 206 DVVHKLPLGNARQVGSLHELLGQADIVTLHVPELPSTQWMIGAAEIAAMKPGGILINASR 265 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 GTVV+I L AL +L GAA+DVFP EP +N D F SPL DN LLTPHIGGST EA Sbjct: 266 GTVVEIDPLAQALKGGNLLGAAVDVFPVEPKSNKDEFVSPLRGLDNALLTPHIGGSTMEA 325 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGG-RRLMHIHENRPGVLTALNKIFA 359 Q NIGLEVA KL++YSDNG++ S+VNFPEV+LP H G RL+H+H N PGVL+ +N I + Sbjct: 326 QANIGLEVAEKLVRYSDNGTSTSSVNFPEVALPEHAGKHRLLHVHHNVPGVLSQINSILS 385 Query: 360 EQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY 410 + +NIAAQYLQT+ ++GYVVID++A AL+ + +PGTIR+R+LY Sbjct: 386 DNHINIAAQYLQTNEKIGYVVIDLDARSSDL--ALEKLAQVPGTIRSRVLY 434 >UniRef50_C6W4R7 HAD-superfamily hydrolase, subfamily IB (PSPase-like) n=40 Tax=Bacteria RepID=C6W4R7_DYAFD Length = 635 Score = 502 bits (1293), Expect = e-140, Method: Composition-based stats. Identities = 223/407 (54%), Positives = 291/407 (71%), Gaps = 4/407 (0%) Query: 5 SLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTH 64 S K +IK LL+E VH A ++ G+ N+EF KGALD+++L E I+D IG+RS+T Sbjct: 232 SYPKSRIKVLLLENVHPVARKAFEDEGF-NVEFVKGALDEDELCERIKDVSIIGIRSKTT 290 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 +T+ V+ A +L+AIG FCIGTNQ+DLD AAK+GI VFNAP+SNTRSV EL +GE++LL+ Sbjct: 291 ITKRVLEHANRLMAIGAFCIGTNQIDLDEAAKKGIAVFNAPYSNTRSVVELAVGEMILLI 350 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 R + + H+G+W+K A GSFE RGKKLG++GYG IGTQL ++AE+LGM VYFYD Sbjct: 351 RNIVGKSNSMHKGIWDKSANGSFEIRGKKLGMVGYGSIGTQLSVVAEALGMDVYFYDAVE 410 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 KL +GNA +V L +LL MSDV+SLHV NM+G +E LMK G + +N SRG VV Sbjct: 411 KLSIGNAKKVNTLEELLAMSDVLSLHVDGRKENTNMIGKREFDLMKDGVIFLNLSRGHVV 470 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 DI AL DA+ S +AGA +DVFP EP TN + F S L NV+LTPHIGGST+EAQENI Sbjct: 471 DIKALADAVKSGKVAGAGVDVFPKEPKTNDEMFESELLGLPNVILTPHIGGSTEEAQENI 530 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEVSLP-LHGGRRLMHIHENRPGVLTALNKIFAEQGV 363 G V KL+++ +NGS+ +VNFPEV LP L RL+HIH N PGVL LN+IFA+ + Sbjct: 531 GHFVPSKLLEFMNNGSSYGSVNFPEVQLPKLKDSHRLLHIHANVPGVLAKLNQIFAKNNI 590 Query: 364 NIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY 410 NI QYL+T+ +GYV++DI D E+ +Q +K + GTIR R+LY Sbjct: 591 NITGQYLKTNEHIGYVIVDIAKDYT--EEFIQEVKEVEGTIRFRMLY 635 >UniRef50_P40054 D-3-phosphoglycerate dehydrogenase 1 n=76 Tax=cellular organisms RepID=SERA_YEAST Length = 469 Score = 494 bits (1273), Expect = e-138, Method: Composition-based stats. Identities = 199/414 (48%), Positives = 277/414 (66%), Gaps = 17/414 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K LL+E V+Q A+ GY +EF+K +L +E+L E I+D H IG+RS+T LT +V+ Sbjct: 59 MKILLLENVNQTAITIFEEQGYQ-VEFYKSSLPEEELIEKIKDVHAIGIRSKTRLTSNVL 117 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A+ LV IGCFCIGTNQVDLD A RGI VFN+PFSN+RSVAELVI E++ L R + + Sbjct: 118 QHAKNLVCIGCFCIGTNQVDLDYATSRGIAVFNSPFSNSRSVAELVIAEIISLARQLGDR 177 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + + H G WNK+AA +E RGK LGIIGYGHIG+QL +LAE++G++V +YDI + LG Sbjct: 178 SIELHTGTWNKVAARCWEVRGKTLGIIGYGHIGSQLSVLAEAMGLHVLYYDIVTIMALGT 237 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 A QV L +LLN SD V+LHVP P T+ M+ A + + MK G+ +INASRGTVVDIP+L Sbjct: 238 ARQVSTLDELLNKSDFVTLHVPATPETEKMLSAPQFAAMKDGAYVINASRGTVVDIPSLI 297 Query: 251 DALASKHLAGAAIDVFPTEPATNS--------DPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 A+ + +AGAA+DV+P EPA N + +TS L N++LTPHIGGST+EAQ Sbjct: 298 QAVKANKIAGAALDVYPHEPAKNGEGSFNDELNSWTSELVSLPNIILTPHIGGSTEEAQS 357 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVNFPEVSL-----PLHGGRRLMHIHENRPGVLTALNKI 357 +IG+EVA L KY + G+++ +VNFPEV+L R+++IH+N PGVL +N I Sbjct: 358 SIGIEVATALSKYINEGNSVGSVNFPEVALKSLSYDQENTVRVLYIHQNVPGVLKTVNDI 417 Query: 358 FAEQGVNIAAQYLQTSAQMGYVVIDIEA-DEDVAEKALQAMKAIPGTIRARLLY 410 + NI Q+ ++ ++ Y++ DI + D+ + + + I RLLY Sbjct: 418 LSNH--NIEKQFSDSNGEIAYLMADISSVDQSDIKDIYEQLNQTSAKISIRLLY 469 >UniRef50_A9EWF7 Phosphoglycerate dehydrogenase n=17 Tax=cellular organisms RepID=A9EWF7_SORC5 Length = 419 Score = 492 bits (1268), Expect = e-137, Method: Composition-based stats. Identities = 202/406 (49%), Positives = 283/406 (69%), Gaps = 4/406 (0%) Query: 6 LEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 + K+ +K LL+E +HQ A E R+ + IE A+ +++L ++ +G+RS+TH+ Sbjct: 17 VAKEPVKVLLLENIHQSAHELFRSRSFE-IETRSSAMKEDELIAALAGVDMLGIRSKTHV 75 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 T V+ A+KL++IGCFCIGTNQVDLDAA +RG+PVFNAPFSNTRSVAE++I E ++L R Sbjct: 76 TARVLEKADKLLSIGCFCIGTNQVDLDAANRRGVPVFNAPFSNTRSVAEMIIAESIMLAR 135 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 + + + + H G W K++ +E RGK +G+IGYGHIG QLG+LAE++GM V +YDI K Sbjct: 136 QLGDRSREVHAGTWKKVSKACYEIRGKTIGLIGYGHIGQQLGVLAEAMGMRVVYYDIAQK 195 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 LP+GN + L LL SD VSLHVP P T NM+GA E++ M+ G+ L+NASRG+VV Sbjct: 196 LPMGNNRALPTLEALLAESDFVSLHVPATPETHNMIGAAELAHMRKGAYLLNASRGSVVV 255 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 IPAL +AL S HLAGAAIDV+P EP +NSD F + L + NV+LTPHIGGST+EAQE IG Sbjct: 256 IPALAEALKSGHLAGAAIDVYPEEPESNSDGFLTELQKLPNVILTPHIGGSTEEAQEAIG 315 Query: 306 LEVAGKLIKYSDNGSTLSAVNFPEVSLPL-HGGRRLMHIHENRPGVLTALNKIFAEQGVN 364 EV+ L + G+T AVNFP V LP R++++H N PGVL +N+I ++ N Sbjct: 316 REVSRALTQLVTTGATTGAVNFPNVELPPLKATHRILNVHRNVPGVLRDVNRIVSDVNAN 375 Query: 365 IAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY 410 I +Q L T A +GY+++D+ +DV+ + + + A+ +IR R+LY Sbjct: 376 IDSQVLSTDANIGYLIMDLS--QDVSAEVSRRIGALETSIRTRVLY 419 >UniRef50_D2VJX3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VJX3_NAEGR Length = 405 Score = 491 bits (1266), Expect = e-137, Method: Composition-based stats. Identities = 200/409 (48%), Positives = 280/409 (68%), Gaps = 7/409 (1%) Query: 4 VSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRT 63 S K IK LL+E + Q A++ + G+ +E +L +E+L I D H +G+RS+T Sbjct: 2 TSYPKHLIKVLLLENISQTAVDLFKKEGFQ-VESVSKSLSEEELTVKIEDVHLVGIRSKT 60 Query: 64 HLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLL 123 LTE V++ A+KL A+GC+CIGT+QVDL+ K+GIPVFN+P++NTRSVAEL + E+++L Sbjct: 61 KLTEKVLSNAKKLKAVGCYCIGTDQVDLECCEKKGIPVFNSPYANTRSVAELAMSEIVML 120 Query: 124 LRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE 183 R V E H+G W K+A +E RGK LGI+GYGH+G+QLG+LAE GM V +YDIE Sbjct: 121 SRKVSEHVKSLHQGHWYKIAKDCYEIRGKILGIVGYGHVGSQLGLLAEGFGMSVIYYDIE 180 Query: 184 NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 +KLPLGNA V + +L+ + VSLHVP+ T N++G +I+ M+ GS L+N SRG+V Sbjct: 181 HKLPLGNAKPVDSMEQVLSTAHFVSLHVPKTEQTNNLIGEAQIAQMQKGSYLLNLSRGSV 240 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATN-SDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 VD+ AL AL S HL G A+DVFPTEP + + F+SPL N +LTPHIGGST EAQ+ Sbjct: 241 VDVNALASALKSGHLHGCAVDVFPTEPEKDGDNVFSSPLQNCPNTILTPHIGGSTIEAQD 300 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVNFPEVSL-PLHGGRRLMHIHENRPGVLTALNKIFAEQ 361 IG EVA KLI Y + G TL +VNFP+++ G RL+HIH NR GVL ++N + Q Sbjct: 301 AIGKEVAQKLISYMNEGITLGSVNFPQINPVHYAGCHRLLHIHVNRHGVLKSINALL--Q 358 Query: 362 GVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY 410 N+ +Q L T+ +GY+VI++ D+ VAE+ + +K + TI+AR+L+ Sbjct: 359 DYNVVSQLLGTTKHIGYMVIEL--DKSVAEEVFKQIKELESTIKARVLF 405 >UniRef50_C5DTI9 ZYRO0C08932p n=1 Tax=Zygosaccharomyces rouxii RepID=C5DTI9_ZYGRO Length = 469 Score = 490 bits (1262), Expect = e-137, Method: Composition-based stats. Identities = 195/414 (47%), Positives = 266/414 (64%), Gaps = 17/414 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K LL+E V+ A+ GY +EFHK +L +E+L E I+D H IG+RS+T LT +V+ Sbjct: 59 MKILLLENVNATAVSIFEDQGYQ-VEFHKSSLPEEELIEKIKDVHAIGIRSKTKLTANVL 117 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A+ LV+IGCFCIGTNQVDL A GI VFN+PFSN+RSVAEL+IGE++ L R + + Sbjct: 118 KHAKNLVSIGCFCIGTNQVDLKYATHAGIAVFNSPFSNSRSVAELIIGEIISLARQLGDR 177 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + + H G WNK++ +E RGK LGIIGYGHIG+QL +LAE++GM+V +YD + LG Sbjct: 178 SIELHTGAWNKVSNRCWEVRGKTLGIIGYGHIGSQLSVLAEAMGMHVLYYDTVTIMALGT 237 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 A QV L +LLN SD ++ HVP P TKNM+ A + + MK G+ ++NASRGTVVDIPAL Sbjct: 238 ARQVPTLDELLNNSDFITCHVPATPETKNMLSAPQFAAMKEGAYVLNASRGTVVDIPALI 297 Query: 251 DALASKHLAGAAIDVFPTEPATNS--------DPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 A +AGAA+DV+P+EP N +P+ S L N++LTPHIGGST+EAQ Sbjct: 298 QAFKVGKIAGAALDVYPSEPGKNGAGAFSDDLNPWASELISLPNIILTPHIGGSTEEAQS 357 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVNFPEVSL-----PLHGGRRLMHIHENRPGVLTALNKI 357 IG+EVA L KY + G+++ +VNFPEVSL R+++IH N PGVL +N I Sbjct: 358 AIGVEVAASLTKYINEGTSVGSVNFPEVSLRSLDYDQENTVRVLYIHHNVPGVLKTVNNI 417 Query: 358 FAEQGVNIAAQYLQTSAQMGYVVIDI-EADEDVAEKALQAMKAIPGTIRARLLY 410 + NI Q+ + + Y++ DI D+ + + I RLLY Sbjct: 418 LSNH--NIEKQFSDSKGDIAYLMADISNVDQSDIKNVYDELNQTDAKISIRLLY 469 >UniRef50_Q11WE3 Phosphoserine phosphatase and phosphoglycerate dehydrogenase (D-3-phosphoglycerate dehydrogenase) fusion n=85 Tax=Bacteria RepID=Q11WE3_CYTH3 Length = 633 Score = 486 bits (1253), Expect = e-136, Method: Composition-based stats. Identities = 207/408 (50%), Positives = 278/408 (68%), Gaps = 4/408 (0%) Query: 4 VSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRT 63 +S K++IK LL+E +H A + GYT +E AL++++L E I+D IG+RS+T Sbjct: 229 ISYPKNRIKVLLLENIHTDAFKLFSEEGYT-VEVIASALEEDELIEKIKDVSIIGIRSKT 287 Query: 64 HLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLL 123 +T V+ A KL+AIG FCIGTNQ+DL AA +G+ VFNAPFSNTRSV EL IGE+++L Sbjct: 288 TITAKVLEHAPKLIAIGAFCIGTNQIDLKAAQMKGVAVFNAPFSNTRSVVELAIGEIIML 347 Query: 124 LRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE 183 R E + + H G W+K A SFE RGKKLG++GYG+IG+QL ++AESLGM VY+YDI Sbjct: 348 YRRTLEKSMQMHAGKWDKSAKNSFEIRGKKLGLVGYGNIGSQLSVIAESLGMVVYYYDIV 407 Query: 184 NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 +L LGNA + L +LLN DVVSLHV S K M GAKE + M+ GS+ +N +RG V Sbjct: 408 ERLSLGNAKKCSSLKELLNTVDVVSLHVDGRASNKGMFGAKEFNEMRQGSIFLNLARGPV 467 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 D+ AL + L S + GA +DV+ EP N + F + + NV+LTPHIGGST+EAQ N Sbjct: 468 TDLKALSENLKSGKILGAGLDVYEYEPKNNDEEFINDVRGLPNVILTPHIGGSTEEAQSN 527 Query: 304 IGLEVAGKLIKYSDNGSTLSAVNFPEVSLP-LHGGRRLMHIHENRPGVLTALNKIFAEQG 362 IG V ++ Y +NG+TL +VNFP + LP L G R MH+HEN+PG+L +N +FA+ Sbjct: 528 IGNFVPNRITDYINNGTTLHSVNFPNIQLPELQEGHRFMHLHENQPGILAKINNLFAKHN 587 Query: 363 VNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY 410 +NI AQYL+T+ Q+GYV+ DI D ++ L +K IPGTIR R LY Sbjct: 588 INILAQYLKTNEQVGYVITDIAKIYD--KEVLDELKEIPGTIRFRTLY 633 >UniRef50_Q1CYP3 D-3-phosphoglycerate dehydrogenase n=5 Tax=cellular organisms RepID=Q1CYP3_MYXXD Length = 417 Score = 472 bits (1215), Expect = e-131, Method: Composition-based stats. Identities = 206/401 (51%), Positives = 276/401 (68%), Gaps = 4/401 (0%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 + LL+E +H A E L A G+ +E AL ++L E ++ H +G+RS+T + Sbjct: 19 PFRALLLENIHPSAGEMLAAEGFQ-VERVSSALKPDELAERLKGVHLLGIRSKTTVPLAA 77 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 + AE L+AIG FCIGTNQVDL +A GIPVFNAPFSNTRSVAE+VI E+++L R + E Sbjct: 78 LEHAENLLAIGAFCIGTNQVDLTSANTHGIPVFNAPFSNTRSVAEMVIAEVIVLTRQLFE 137 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 + + H G W K+A GS E RGK LGIIGYGHIG+QLG++AE+LGM V ++D+ KLPLG Sbjct: 138 RSQEVHAGQWRKVATGSHEVRGKTLGIIGYGHIGSQLGVIAEALGMRVLYFDVMTKLPLG 197 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 NA L +LL SD V+LHVP P+T MMGA++I+ MK G+ LINASRGTVVDI AL Sbjct: 198 NAQPAVTLEELLGASDFVTLHVPALPTTHMMMGAEQIAQMKKGACLINASRGTVVDIDAL 257 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 AL S+HL GAA+DV+P EP +NSD F + L NV+LTPHIGGST+EAQ +IG EVA Sbjct: 258 ARALQSQHLGGAAVDVYPEEPESNSDGFVTALQGLPNVVLTPHIGGSTEEAQASIGKEVA 317 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPL-HGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 L+KY G++ AVNFP + PL G R++++H N PGVL +N+I ++ NI AQ Sbjct: 318 TSLLKYFKAGASTGAVNFPNIEAPLIPGTHRILNVHRNIPGVLRDINRIVSDLNANIHAQ 377 Query: 369 YLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 L T A +GY+++D+ D+DV+ +A+ + I+ R+L Sbjct: 378 VLSTDANIGYLLMDL--DQDVSTPVCEAIAGLETDIKTRIL 416 >UniRef50_A3UGW9 D-3-phosphoglycerate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=A3UGW9_9RHOB Length = 407 Score = 469 bits (1209), Expect = e-131, Method: Composition-based stats. Identities = 212/398 (53%), Positives = 273/398 (68%), Gaps = 4/398 (1%) Query: 14 LLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAA 73 LL+E VH A +L+ AG ++ G+ D QL+ I A +G+RSRTH+ +++AA Sbjct: 10 LLLENVHPDADNALQTAGPVTVKRLSGSPDRAQLESEIASASVLGIRSRTHVDAALLDAA 69 Query: 74 EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAK 133 ++L A+GCFCIGTNQVDL AAA+RG+PVFNAPF+NTRSVAEL + +++L+R +PE Sbjct: 70 KELQAVGCFCIGTNQVDLVAAAERGVPVFNAPFANTRSVAELTMASVIMLMRRIPEKMFA 129 Query: 134 AHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQ 193 RG W K A G+ E R KKLGIIGYG+IG QL ++A +LGM+VY+YDI KL GNA Sbjct: 130 IQRGEWLKTADGANEVRKKKLGIIGYGNIGAQLSVIASALGMHVYYYDIAPKLAHGNARP 189 Query: 194 VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDAL 253 + L D+L DVV+LHVP P TKNM+G +I+LMK G+ LIN +RG +VD+ AL DAL Sbjct: 190 MDTLDDILTECDVVTLHVPSTPRTKNMIGKDQIALMKHGAFLINQARGDLVDVDALADAL 249 Query: 254 ASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLI 313 S HLAGAA+DVFP EP + + F SPL NV+LTPHIGGST EAQ+ IGL+ AGKL Sbjct: 250 NSGHLAGAAVDVFPVEPKSKDEKFESPLTRCANVILTPHIGGSTLEAQQAIGLDAAGKLA 309 Query: 314 KYSDNGSTLSAVNFPEVSLPL--HGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQ 371 +Y GST AVNFPEV G R++ H NRPG L LN + G N+AAQ+LQ Sbjct: 310 RYLHEGSTTFAVNFPEVEPGPIQPGRTRILAPHRNRPGFLRRLNDAAEQAGANVAAQFLQ 369 Query: 372 TSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 T +GY V D+E ++ E L ++AI GTIRARL+ Sbjct: 370 TKGDLGYAVADLEG--ELPEDFLDRVRAIDGTIRARLI 405 >UniRef50_D0NEX4 D-3-phosphoglycerate dehydrogenase n=1 Tax=Phytophthora infestans T30-4 RepID=D0NEX4_PHYIN Length = 466 Score = 459 bits (1183), Expect = e-128, Method: Composition-based stats. Identities = 195/412 (47%), Positives = 275/412 (66%), Gaps = 9/412 (2%) Query: 4 VSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRT 63 V+ DKIK +L+E +H +A E GYT +E HK A+ E+L DAH +G+RS+T Sbjct: 57 VTYPLDKIKVVLLENIHPRAKEVFEREGYT-VETHKRAMSGEELARVGGDAHILGIRSKT 115 Query: 64 HLTEDVINAA----EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGE 119 L D N +L A+GCFCIGTNQV L +AA GIPVFNAPFSNTRSVAE + E Sbjct: 116 QLDPDFFNTVGWHEHRLWAVGCFCIGTNQVALPSAAATGIPVFNAPFSNTRSVAEKTLSE 175 Query: 120 LLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYF 179 ++ L R + + + H+G+W K A G+ E RG LGI+GYG IG+Q+ +LAE LGM V F Sbjct: 176 IIALHRKLFLRSTELHQGIWTKSATGAHEVRGTTLGIVGYGRIGSQVSVLAELLGMKVVF 235 Query: 180 YDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINAS 239 YD LPLGNA QV L +LL M+D V+LHVP P+TK M+ + I+ MK G+LL+N + Sbjct: 236 YDPVKCLPLGNARQVDTLEELLGMADAVTLHVPATPTTKKMINRETIAQMKDGALLVNNA 295 Query: 240 RGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQE 299 RGTV+DI A +A+ S +AG A+DVFP EPA N +PF +PL NV+LTPHIGGST+E Sbjct: 296 RGTVIDIDAAKEAVESGKIAGMAVDVFPKEPAKNGEPFDTPLRGLPNVILTPHIGGSTEE 355 Query: 300 AQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSL--PLHGGRRLMHIHENRPGVLTALNKI 357 AQ NI +EVA KL++Y ++GST ++ N PE+ + + R++H+H+N PGVL+ ++ + Sbjct: 356 AQGNIAVEVASKLVRYINDGSTTTSTNTPEIDMLPIRNNSMRILHMHQNVPGVLSKIHSV 415 Query: 358 FAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 ++ G+N+ +QYLQ+ + GY+ +++E A+ + ++ I TI R + Sbjct: 416 LSDYGINVTSQYLQSDPRHGYIALEVEKF--HAKVVTRELEKIKETIFLRTI 465 >UniRef50_C7R3H8 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=19 Tax=Bacteria RepID=C7R3H8_JONDD Length = 416 Score = 459 bits (1183), Expect = e-128, Method: Composition-based stats. Identities = 206/400 (51%), Positives = 261/400 (65%), Gaps = 4/400 (1%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K LL+E VH A+E L + GY I GALD+ +L E+++ H +G+RS+T +T VI Sbjct: 14 LKALLLENVHPTAVEILSSHGYEVI-TRSGALDEAELIEALQGVHLLGIRSKTQVTRQVI 72 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 + A L+AIG FCIGTNQ+DL AAA+RG+ VFNAPFSNTRSV E+ I E++ L R +PE Sbjct: 73 DHAPDLIAIGAFCIGTNQIDLGAAAERGVGVFNAPFSNTRSVVEMAISEMISLTRRLPER 132 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 N H GVW+K A GS E RGK LGIIGYG+IGTQL +LAE+LGM V FYD KL LGN Sbjct: 133 NKAMHDGVWDKTADGSHEIRGKTLGIIGYGNIGTQLSVLAENLGMSVIFYDTAEKLALGN 192 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 A + L +LL +DVV++HV P + GA++ + MK G++ +N SRG V+D AL Sbjct: 193 ARRATTLEELLGAADVVTIHVDGRPGNAGLFGAEQFAAMKRGAIFLNLSRGFVMDNEALR 252 Query: 251 DALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAG 310 DA+ S H+AGAA+DVFPTEP D F S L NV+LTPHIGGST EAQE+IG VA Sbjct: 253 DAIMSGHVAGAAVDVFPTEPKKRGDAFDSELRGLANVILTPHIGGSTLEAQESIGEFVAN 312 Query: 311 KLIKYSDNGSTLSAVNFPEVSLPLHGGR-RLMHIHENRPGVLTALNKIFAEQGVNIAAQY 369 KL Y GST +VN P ++L G R+ +H N PGVL A+N A VNI Q Sbjct: 313 KLRDYVRTGSTTLSVNLPNLALETTGSITRIAFLHRNTPGVLAAVNNALATHNVNIDGQL 372 Query: 370 LQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 L T + GYVV D A V + L A+K I IR R++ Sbjct: 373 LATRGEFGYVVTD--AGSSVDPEVLNALKDIDQYIRIRVM 410 >UniRef50_D2RHI0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RHI0_ARCPR Length = 525 Score = 450 bits (1158), Expect = e-125, Method: Composition-based stats. Identities = 116/325 (35%), Positives = 182/325 (56%), Gaps = 8/325 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ + + ++A++ ++ G K + E+L E I+D + +RSRT +T DVI Sbjct: 1 MKVLVADPIAEEAIDFMKKNGLEV--DVKTDISHEELLEVIQDYDALIVRSRTRVTRDVI 58 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 + A+KL IG +G + +D+D A ++GI V NAP N+ S AE IG +L + R +P+A Sbjct: 59 DRAKKLKIIGRAGVGVDNIDVDYATEKGIVVVNAPGGNSVSAAEHTIGLILSIARKIPQA 118 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKLPL 188 + G W + E RGK LGI+G G IG ++ M + YD + Sbjct: 119 DRSVKEGKWERKKFVGIELRGKTLGIVGLGRIGYEVAKRMRCFEMNILAYDPYVSEERAK 178 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 ++ L +LL SD++++HVP+ T+ M+ KE +MK G +INA+RG +VD A Sbjct: 179 SVGAKLVSLEELLRNSDIITIHVPKTKETEKMISYKEFEIMKDGVYIINAARGGIVDEKA 238 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L DAL S +AGAA+DV+ EP + PL + +NV+ TPHIG ST+EAQ +G+ V Sbjct: 239 LYDALVSGKVAGAALDVYEKEPPDKDN----PLLKLENVVTTPHIGASTREAQMMVGMTV 294 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLP 333 A ++ + +AVN P ++ Sbjct: 295 AEDIVNFFKGLPVKNAVNLPSIAPE 319 Score = 41.1 bits (96), Expect = 0.067, Method: Composition-based stats. Identities = 18/79 (22%), Positives = 38/79 (48%), Gaps = 2/79 (2%) Query: 334 LHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQM--GYVVIDIEADEDVAE 391 + G ++ +HE++PGV+ + + + +NIA + G ++ + D+ E Sbjct: 446 VPKGHYVISLHEDKPGVIGRVGTLMGKYNINIAGMIVGRYGDKPGGIQLMLLLLDDPPTE 505 Query: 392 KALQAMKAIPGTIRARLLY 410 + L+ M + G I A +Y Sbjct: 506 EILKKMVELEGIIDATYVY 524 >UniRef50_C6HZG9 D-3-phosphoglycerate dehydrogenase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HZG9_9BACT Length = 537 Score = 445 bits (1147), Expect = e-123, Method: Composition-based stats. Identities = 124/410 (30%), Positives = 199/410 (48%), Gaps = 24/410 (5%) Query: 9 DKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 KIK L+ + + ++ + + AG+ K L ++LK + + +RS T +T Sbjct: 5 HKIKILVSDPISEEGINIFKNAGFEVT--VKAKLSPDELKAELAHYDGLVIRSGTKVTAH 62 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 V+ A +L IG G + VDL AA RGI V N P NT + AE + ++ + R +P Sbjct: 63 VLEGATRLKVIGRAGAGLDNVDLPAATNRGIVVMNTPGGNTITTAEHTVSMMMSMARRIP 122 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--ENKL 186 +ANA G W K E K LGI+G G IG+ + +A+ L M V YD + Sbjct: 123 QANASNRSGKWEKSKFMGIELAHKTLGILGMGKIGSHVAHVAQGLLMNVIAYDPFLTAES 182 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + +L +D++++H P P T N++ + I+ MK G ++N +RG +V+ Sbjct: 183 AARQGVTPVTVEELFAKADIITVHTPLTPETTNLISSASIAKMKKGVYIVNCARGGIVNE 242 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 L AL S H+AGAA DVF EP + + PL + DN + TPHIG +T+EAQEN+ L Sbjct: 243 ADLAKALESGHVAGAAFDVFAEEPPSPDN----PLLKLDNFISTPHIGAATKEAQENVAL 298 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLM---HIHENRPGVLTA--------LN 355 VA +++ Y G A N P V P R+ + E G+L+ ++ Sbjct: 299 AVADQMVDYLAKGIIRYAANLPSV--PPEDAARVTPYQQLAEVMGGILSQIATEAFSKIS 356 Query: 356 KIFAEQGVNIAAQYLQTSAQMGYV--VIDIEADEDVAEKALQAMKAIPGT 403 F+ + + Q + +A G + ++D+ +E V L + + Sbjct: 357 VEFSGEAATLPTQIITIAALKGVLAPMLDVRVNE-VNAPLLAKERGLEVV 405 >UniRef50_C8WVY8 D-3-phosphoglycerate dehydrogenase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WVY8_ALIAD Length = 529 Score = 443 bits (1140), Expect = e-123, Method: Composition-based stats. Identities = 116/322 (36%), Positives = 179/322 (55%), Gaps = 7/322 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + Q ++ L + + L ++LKE+I DA + +RS+T +T DVI Sbjct: 4 KILVTDDISQAGIDILSGLQGAEV-VVRTNLAPDELKEAIADADALVVRSQTRVTRDVIE 62 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 +A+KL IG +G + +DL+AA +RGI V NAP NT + AE ++ L R +P A+ Sbjct: 63 SAKKLKVIGRAGVGVDNIDLEAATRRGILVINAPDGNTIAAAEHTFAMMISLARHIPAAH 122 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--ENKLPLG 189 +G WN+ E RGK L ++G G IGT++ A++ GM V YD + Sbjct: 123 RDLLQGNWNRKKWIGVELRGKTLAVLGMGRIGTEVAKRAKAFGMTVLGYDPFLTEERAQS 182 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 + L + +D +++H P T +M+ A I+ MK G +IN +RG ++D AL Sbjct: 183 LGVKRCDLDTAIREADFITVHTPLTKETHHMIDAGRIAQMKEGVRIINCARGGIIDEVAL 242 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 +AL + +AGAAIDVF EP P PL NV+LTPH+G ST EAQEN+ ++VA Sbjct: 243 AEALEAGRVAGAAIDVFEQEPL----PMDHPLRRCPNVVLTPHLGASTVEAQENVAIQVA 298 Query: 310 GKLIKYSDNGSTLSAVNFPEVS 331 ++++ + + AVN P +S Sbjct: 299 EEIVQVLRDDTFEHAVNLPSLS 320 Score = 49.6 bits (118), Expect = 2e-04, Method: Composition-based stats. Identities = 15/70 (21%), Positives = 32/70 (45%) Query: 340 LMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKA 399 + HE+RPG++ + + ++ +NIA + G V+ + D+ V + + + Sbjct: 458 IYTRHEDRPGMIGRIGTLLGDRDINIAGMQVGRRETGGEAVMLLSVDKRVPQDVIDEIAK 517 Query: 400 IPGTIRARLL 409 PG R + Sbjct: 518 HPGIRLVRAI 527 >UniRef50_A5D6D4 Phosphoglycerate dehydrogenase and related dehydrogenases n=3 Tax=Firmicutes RepID=A5D6D4_PELTS Length = 526 Score = 438 bits (1128), Expect = e-121, Method: Composition-based stats. Identities = 131/366 (35%), Positives = 196/366 (53%), Gaps = 14/366 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+++GV ++ L++LR ++ K + +++L +I D I +RS T +T +I Sbjct: 1 MKVLVLDGVEEEGLKALRQEPGIQVDV-KDKMSEDELVAAIGDYDGIIVRSATKVTARII 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A +L +G +G + +D+ AA RGI V NAP NT +VAE I +L L R +P+A Sbjct: 60 EKAARLKVVGRAGVGVDNIDVPAATARGILVVNAPEGNTLAVAEHTIAMMLSLARNIPQA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 NA G W+K + E RGK LG+IG G IG+ + A+ + M V YD Sbjct: 120 NASLRAGKWDKKSFMGVELRGKVLGVIGLGRIGSAVAKRAQGMEMKVVAYDPYINEEKAG 179 Query: 191 ATQVQ--HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 V L +LL +D +++H+P +K M+G K SLMK G +IN +RG VVD A Sbjct: 180 LLGVTLLSLEELLKQADFITVHLPLTRESKYMLGEKAFSLMKDGVRIINCARGGVVDEQA 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +A+ S +AGAA+DVF EP T SPL EF N + TPH+G STQEAQ ++ +V Sbjct: 240 LYNAMKSGKVAGAALDVFEKEPNT-----DSPLFEFKNFIATPHLGASTQEAQLSVATDV 294 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPG------VLTALNKIFAEQG 362 A +++ +AVN P VS + + + G + +NKI A Sbjct: 295 AREVVAALKGELVKNAVNIPSVSPKVLAVIKPYLSLAEKMGKFAAQVICGRVNKIEATYS 354 Query: 363 VNIAAQ 368 ++A Q Sbjct: 355 GDLAGQ 360 Score = 42.3 bits (99), Expect = 0.031, Method: Composition-based stats. Identities = 13/75 (17%), Positives = 30/75 (40%) Query: 333 PLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEK 392 + G L H ++P ++ + + +NI+ + G V+ + D V E+ Sbjct: 448 AVPEGHMLYIPHIDKPRIIGPVGNLIGTHNINISGMQVGRKVIGGKAVMLLNIDSPVPEE 507 Query: 393 ALQAMKAIPGTIRAR 407 + + I G + + Sbjct: 508 TMAEIAKIDGVLGVK 522 >UniRef50_O29445 D-3-phosphoglycerate dehydrogenase n=8 Tax=cellular organisms RepID=SERA_ARCFU Length = 527 Score = 438 bits (1128), Expect = e-121, Method: Composition-based stats. Identities = 107/325 (32%), Positives = 173/325 (53%), Gaps = 8/325 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ E + ++A++ +R G K + E+L + I +RS+T + +VI Sbjct: 1 MKVLVAEPISEEAIDYMRKNGLEV--EVKTGMSREELIREVPKYEAIVVRSQTKVDAEVI 58 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA+ L IG +G + +D++AA +RGI V NAP NT S AE I +L R +P+A Sbjct: 59 QAAKNLKIIGRAGVGVDNIDINAATQRGIVVVNAPGGNTISTAEHAIALMLAAARKIPQA 118 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--ENKLPL 188 + G W + E RGK G+IG G +G ++ ++L M V YD + Sbjct: 119 DRSVKEGKWERKKFMGIELRGKTAGVIGLGRVGFEVAKRCKALEMNVLAYDPFVSKERAE 178 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 ++ LL SDV+++HVP T ++G + MK G +++NA+RG +VD A Sbjct: 179 QIGVKLVDFDTLLASSDVITVHVPRTKETIGLIGKGQFEKMKDGVIVVNAARGGIVDEAA 238 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +A+ + +A AA+DV+ EP + + PL + DNV+ TPHI ST+EAQ N+G+ + Sbjct: 239 LYEAIKAGKVAAAALDVYEKEPPSPDN----PLLKLDNVVTTPHIAASTREAQLNVGMII 294 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLP 333 A ++ + +AVN P + Sbjct: 295 AEDIVNMAKGLPVRNAVNLPSIEPS 319 Score = 43.8 bits (103), Expect = 0.011, Method: Composition-based stats. Identities = 21/87 (24%), Positives = 40/87 (45%), Gaps = 8/87 (9%) Query: 325 VNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQM--GYVVID 382 VNF + G ++ +HE++PGV+ + +F +NIA + S G ++ Sbjct: 445 VNF------VPKGHYIISLHEDKPGVIGRVGTLFGRNNINIAGMIVGRSGDKPGGIQLML 498 Query: 383 IEADEDVAEKALQAMKAIPGTIRARLL 409 + D+ + L+ M + G I A + Sbjct: 499 LLVDDPPTPEVLEEMTKLDGIIDATYV 525 >UniRef50_B8HPZ0 D-3-phosphoglycerate dehydrogenase n=26 Tax=cellular organisms RepID=B8HPZ0_CYAP4 Length = 652 Score = 438 bits (1127), Expect = e-121, Method: Composition-based stats. Identities = 118/390 (30%), Positives = 196/390 (50%), Gaps = 29/390 (7%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K L+ + + Q ++ L ++ L E+L + I D + +RS T +T+ VI Sbjct: 128 PKVLVSDPIDQVGIDLLAQVAQVDVRTD---LSPEELIQIIPDYDALMIRSGTKVTQAVI 184 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA +L IG +G + VD+ AA ++GI V N+P NT + AE + +L L R +P A Sbjct: 185 EAANQLKIIGRAGVGVDNVDVPAATRKGIVVVNSPEGNTIAAAEHTLAMMLSLSRHIPAA 244 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKLPL 188 + G W++ + E K LG+IG G IG+ + +A ++GM + YD N+ Sbjct: 245 SQSVKSGKWDRKSFTGVEVYKKTLGVIGLGKIGSHVATVARAMGMNLLAYDPYLSNERAE 304 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 ++ +L L +D ++LH+P+ P T++++ A+ ++ MKP + +IN +RG ++D A Sbjct: 305 QIGCRLVNLDLLFAEADYITLHLPKTPETQHLIKAETLARMKPTARIINCARGGIIDEAA 364 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDN-VLLTPHIGGSTQEAQENIGLE 307 L +AL +AGAA+DVF EP SPL V+LTPH+G ST+EAQ N+ ++ Sbjct: 365 LVEALKEGKIAGAALDVFENEPLGE-----SPLLSLGKEVVLTPHLGASTEEAQTNVAID 419 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAA 367 VA ++ SAVN P G R + + +P + AE N+ Sbjct: 420 VAEQIRDLFLGKPVRSAVNIP--------GLRPDVLEKLKPYL------QLAETLGNLVG 465 Query: 368 QYLQTSAQMGYVVIDIEADEDVAEKALQAM 397 Q + +D+ ++A Q + Sbjct: 466 QLAGGRIEA----LDVRLQGELASNDSQPI 491 >UniRef50_C2BW43 Phosphoglycerate dehydrogenase n=1 Tax=Mobiluncus curtisii ATCC 43063 RepID=C2BW43_9ACTO Length = 413 Score = 436 bits (1123), Expect = e-121, Method: Composition-based stats. Identities = 181/400 (45%), Positives = 251/400 (62%), Gaps = 5/400 (1%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K LL+E H+ A + A ++ G+LD+ L ++++ +G+RS+T+L++ V + Sbjct: 3 KILLLENPHEVANKVFSDAN-VQVDRIDGSLDENDLIKALQGYQMVGIRSKTNLSKRVFD 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 LV G F IGTNQ+DL AAK G+ VFNAP+SNTRSVAEL I E++ L R +P N Sbjct: 62 ECPDLVCAGTFTIGTNQIDLKEAAKHGVAVFNAPYSNTRSVAELAIAEIIALARQLPVRN 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 A W K A GS E RGK LGIIGY GTQL ILAE++GM V FYD+ KLP+GNA Sbjct: 122 AHLQNADWQKTAKGSHEVRGKTLGIIGYSSTGTQLSILAEAMGMKVQFYDLAKKLPIGNA 181 Query: 192 TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCD 251 Q L + L +D VSLHV S +NM +++ MKPG+ L+N SRG VV++ L + Sbjct: 182 KQCNSLEEALQGADFVSLHVDGRASNENMFTKVQMNQMKPGAKLLNLSRGFVVNLDDLAE 241 Query: 252 ALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGK 311 AL S + G AIDVFP EP N + F SP+ +N +LTPHIGGST EAQE+IG VAGK Sbjct: 242 ALDSGQIGGCAIDVFPDEPRKNGEEFHSPIMGKENTILTPHIGGSTLEAQEDIGWFVAGK 301 Query: 312 LIKYSDNGSTLSAVNFPEVSLPL--HGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQY 369 + Y +G T+ +VN P +SL + R+ IH+N PGV+ +N++F++ GVNI Q Sbjct: 302 ICTYLQSGETVMSVNMPNLSLEPTDNTKYRITLIHKNVPGVMAKINQLFSDAGVNIEGQV 361 Query: 370 LQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 L T+ ++GYV+ DI + ++ + AL + T+ R + Sbjct: 362 LGTNGEVGYVIGDISS--EMPKAALDEIAKFDSTLSVRCI 399 >UniRef50_Q1AXS3 D-3-phosphoglycerate dehydrogenase n=2 Tax=Actinobacteria (class) RepID=Q1AXS3_RUBXD Length = 527 Score = 435 bits (1119), Expect = e-120, Method: Composition-based stats. Identities = 129/390 (33%), Positives = 199/390 (51%), Gaps = 15/390 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 ++ L+ E + ++ +E LR ++ L +L E I + + +RS T +T +VI Sbjct: 1 MRVLVTEKLAERGVELLRREFEVDVLL---GLSPGELLERIGEYDGLIVRSATKVTAEVI 57 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA +L AIG IG + +D++AA KRGI V NAP SNT + AE +G +L + R +P A Sbjct: 58 EAAGRLKAIGRAGIGVDNIDIEAATKRGILVANAPESNTVAAAEHTLGLMLAVARRIPAA 117 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI---ENKLP 187 +A RG WN+ A E K LG++G GH+G+ + A +GM V YD E ++ Sbjct: 118 DASLRRGEWNRAAFKGVEVAEKTLGLVGLGHVGSIVARGALGMGMRVLAYDPYVSEERMR 177 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 N + L ++ +D VSLHVP P T M+G +E++ MKP + LIN +RG +VD Sbjct: 178 SMNVERAGSLEEIFEEADFVSLHVPRTPQTTGMVGEEELARMKPTAYLINVARGGIVDET 237 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL +AL +AGAA+DVF EP T SPL NV++TPH+G ST EAQ+ G+ Sbjct: 238 ALYNALKQGEIAGAALDVFAEEPTT-----DSPLFALPNVVVTPHLGASTAEAQDRAGVT 292 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAE-QGVNIA 366 A ++ + A+N P +P G + L L + G + Sbjct: 293 AAEQVAAALRGEVPIHAINAP---VPAGEGAEFVSQFAGLCETLGRLLYQLTDRPGSRLK 349 Query: 367 AQYLQTSAQMGYVVIDIEADEDVAEKALQA 396 +Y ++D+ + + + + Sbjct: 350 IEYRGEIGAYDTRLLDVSVQKGLLSRMVHE 379 Score = 42.3 bits (99), Expect = 0.035, Method: Composition-based stats. Identities = 17/68 (25%), Positives = 31/68 (45%) Query: 340 LMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKA 399 L +E+ PG++ + I E G+NI + + + DE V + ++++ Sbjct: 455 LFIRNEDVPGMIGKVGTILGEHGINIGNMAVGRGEPGSRAAMAVTVDEPVPPEVVESLLN 514 Query: 400 IPGTIRAR 407 IPG AR Sbjct: 515 IPGFNDAR 522 >UniRef50_O27051 D-3-phosphoglycerate dehydrogenase n=16 Tax=Archaea RepID=SERA_METTH Length = 525 Score = 435 bits (1119), Expect = e-120, Method: Composition-based stats. Identities = 121/378 (32%), Positives = 187/378 (49%), Gaps = 17/378 (4%) Query: 9 DKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 ++K L+ + +++K + + E+L ++I+D I +RSRT +T + Sbjct: 2 SRMKVLIADSINEKGI---SELEEVAEVVVNTTITPEELLDAIKDFDAIVVRSRTKVTRE 58 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 VI AA +L I +G + VD+ AA RGI V NAP S + +VAE IG +L L R + Sbjct: 59 VIEAAPRLKIIARAGVGVDNVDVKAATDRGIMVINAPESTSITVAEHSIGLMLALARKIA 118 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKL 186 A+ G W K E GK LGIIG G IG+Q+ + ++ GM + YD + Sbjct: 119 IADRSVKEGKWEKNRFMGIELNGKTLGIIGMGRIGSQVVVRTKAFGMDIMVYDPYISKEA 178 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 V L LL SD+V++HVP P T++++ E LMK + ++N +RG ++D Sbjct: 179 AEEMGVTVTDLETLLRESDIVTIHVPLTPETRHLISEDEFKLMKDTAFIVNCARGGIIDE 238 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL AL +AGAA+DVF EP P SPL E +NV+LTPHIG ST EAQ + + Sbjct: 239 DALYRALKDGEIAGAALDVFEEEP-----PEGSPLLELENVVLTPHIGASTSEAQRDAAI 293 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMH-IHENRPGVLTALNKIFAEQGVNI 365 VA ++ G+ + +N P + + + + E ++ NI Sbjct: 294 IVANEIKTVFQGGAPRNVLNMPVMDSETYKSLKPYIELAEKMGAIIAQALP------GNI 347 Query: 366 AAQYLQTSAQMGYVVIDI 383 + ++ + DI Sbjct: 348 EKLDVTYCGELAEMQFDI 365 >UniRef50_B4D991 D-3-phosphoglycerate dehydrogenase n=3 Tax=Verrucomicrobia RepID=B4D991_9BACT Length = 530 Score = 431 bits (1109), Expect = e-119, Method: Composition-based stats. Identities = 116/326 (35%), Positives = 173/326 (53%), Gaps = 8/326 (2%) Query: 9 DKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 K K L+ + + QK ++ L G ++ K L ++L I + + + +RS T Sbjct: 2 SKPKVLVADPIAQKGIDELANGGSLDVTV-KIGLKPDELLAIIGEFNALVVRSETKANAK 60 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 VI AA L IG +G + VD+DAA KRGI V N P NT S AE ++ R +P Sbjct: 61 VIEAATNLKVIGRAGVGVDNVDVDAATKRGIIVMNTPGGNTISTAEHAFSLMVSTARNIP 120 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL 188 +A+A G W++ E K L I+G G IGT++ A + GM V YD Sbjct: 121 QADASVKSGKWDRKTFVGVELYNKTLAILGMGRIGTEIARRAIAFGMRVLAYDPYLSASR 180 Query: 189 GNATQ---VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 + Q V+ L ++ +D ++LH+P TK M+ A+ ++ K G ++N +RG ++D Sbjct: 181 ARSLQVELVESLDLIIPQADFITLHMPLTAETKYMLNAERLAKTKKGVRIVNCARGGLID 240 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL +AL SK +A AA+DVF EP P SPL N++LTPH+G ST EAQE +G Sbjct: 241 EAALVEALKSKQVAAAALDVFEAEPL----PAESPLRGLPNLILTPHLGASTAEAQEGVG 296 Query: 306 LEVAGKLIKYSDNGSTLSAVNFPEVS 331 +EVA ++ +G +AVN P + Sbjct: 297 IEVAEQIRAALLSGEIRNAVNMPSID 322 >UniRef50_A6UQN3 D-3-phosphoglycerate dehydrogenase n=4 Tax=Euryarchaeota RepID=A6UQN3_METVS Length = 523 Score = 427 bits (1100), Expect = e-118, Method: Composition-based stats. Identities = 125/390 (32%), Positives = 211/390 (54%), Gaps = 28/390 (7%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ + +H+ A+E L+ AG I + E++K+ I+DA + +RS T +T+++I Sbjct: 2 LKILITDPLHESAIEILKEAGEVEI---ATGISIEEIKQKIKDADALVVRSGTTVTKEII 58 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +A+E L I +G + VDLDAA ++G+ V NAP +++ SVAEL+ G +L R +P+A Sbjct: 59 DASENLKVIARAGVGVDNVDLDAATEKGVVVVNAPDASSISVAELMFGLMLSAARNIPQA 118 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKLPL 188 A +G W++ + E K LGI+G G IG Q+ A++ M + YD + Sbjct: 119 TASLKKGEWDRKSFKGMEVYAKTLGIVGLGRIGQQVAKRAQAFEMNIVAYDPYIPENVAS 178 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 ++ + +L S+ ++LHVP TK+M+G + LMK +++IN +RG ++D A Sbjct: 179 ELGIKLLSVDELCAESEFITLHVPLTTKTKHMIGKTQFDLMKNNTIIINCARGGLIDENA 238 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L DA+ + A +DVF EP T +PL + ++ TPH G ST+EAQ + G V Sbjct: 239 LYDAINCGKVKAAGLDVFEEEPPTK-----NPLISLNGLIGTPHQGASTEEAQLSAGTIV 293 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 A + +K S + VN P V P ++LM P + + AE+ +++ Q Sbjct: 294 AEQTVKILKGESAENVVNLPMV--PTEKMKKLM------PYL------VLAEKMGSMSIQ 339 Query: 369 YLQTSAQMGYVVIDIEADEDVAEKALQAMK 398 YL S + ++I D+A++ + +K Sbjct: 340 YLDNSIDI----VEITYMGDLAKEKTEMLK 365 Score = 50.0 bits (119), Expect = 2e-04, Method: Composition-based stats. Identities = 16/66 (24%), Positives = 32/66 (48%) Query: 344 HENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGT 403 H +RPG++ + I E G+NIA + G+ ++ ++ D + E+ + +K I Sbjct: 456 HIDRPGMVGKVGLILGEHGINIAGMQVGRKEPGGHSIMFLDIDHMIPEEVMDEIKKIENV 515 Query: 404 IRARLL 409 R + Sbjct: 516 RAVRAI 521 >UniRef50_A6G5P3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6G5P3_9DELT Length = 405 Score = 427 bits (1098), Expect = e-118, Method: Composition-based stats. Identities = 192/406 (47%), Positives = 261/406 (64%), Gaps = 12/406 (2%) Query: 15 LVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESI-----RDAHFIGLRSRTHLTEDV 69 + E +H A ++ A + L E++ E++ IG+RS+T + + Sbjct: 1 MSESIHASASDAFERA-DVQVHRTSAGLGPEEIIEALNGLPGDGPVMIGVRSKTKVRAPI 59 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 A +L A+G FCIGT+Q+DL+ AA+ G+ VFNAPFSNTRSVAELVI E++ L R + E Sbjct: 60 FEAVPRLAAVGAFCIGTDQIDLEVAAQSGVAVFNAPFSNTRSVAELVIAEIVCLSRQLFE 119 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 + AH G W K A G+ E RGK LGIIGYGHIG+QL +LAE++G+ V ++DI NKLPLG Sbjct: 120 RSWAAHEGRWRKDAKGAHEVRGKTLGIIGYGHIGSQLSVLAEAMGLRVRYHDIVNKLPLG 179 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 NA+ + L LL SD VSLHVP P T+NM GA E++ MKPG+ LINASRGTVVDI AL Sbjct: 180 NASASESLDALLAGSDFVSLHVPNTPQTRNMFGAAELAKMKPGAYLINASRGTVVDIEAL 239 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 +L S H+AGAA+DV+P EP + +DPF SPL V+LTPHIGGSTQEAQ NIG+EV+ Sbjct: 240 RASLESGHVAGAALDVYPKEPKSTADPFESPLQGLRQVILTPHIGGSTQEAQANIGVEVS 299 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPL--HGGRRLMHIHENRPGVLTALNKIFAEQGVNIAA 367 L Y+ G T + P + P G RL++IH + PGVLT+ N+ ++ G+NI Sbjct: 300 EALAAYTRFGRTTGCITLPAIDAPAISPGRSRLLNIHRDVPGVLTSANQRVSDAGLNITG 359 Query: 368 QYLQTSAQMGYVVIDIEADEDVA--EKALQAMKAIPGTI--RARLL 409 Q L+T A +G +++D++A D E + + ++ R RLL Sbjct: 360 QRLETQAGVGLLLMDVDAKSDDPRVESLRADLAGLAQSLPRRTRLL 405 >UniRef50_A0LMX1 D-3-phosphoglycerate dehydrogenase n=1 Tax=Syntrophobacter fumaroxidans MPOB RepID=A0LMX1_SYNFM Length = 525 Score = 426 bits (1097), Expect = e-118, Method: Composition-based stats. Identities = 110/343 (32%), Positives = 177/343 (51%), Gaps = 8/343 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ +G+H+ L LRAA +++ E++K + D + +RSRT +T ++I Sbjct: 1 MKVLICDGMHEVGLSILRAAEGIDVDV-PDQPGAEEIKAMLPDYDAVIVRSRTRITAELI 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A +L IG G + +D+ AA+ RG V N P +N + AE I +L L R +P+A Sbjct: 60 ENAPRLKVIGRAGTGVDNIDVKAASARGALVMNTPGANATAAAEHTIAMMLALARHIPQA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKLPL 188 G W+K E + LGIIG G IG+ + A S+ M V +D + Sbjct: 120 TQSMREGRWDKKRFMGTELFHQTLGIIGLGKIGSIVADRALSMKMDVLGHDPYIIPEAAA 179 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + L +LL SD ++LH P T ++ + ++ KPG ++N +RG ++D A Sbjct: 180 ILGVEWVPLDELLARSDFLTLHTPSTSETVRILNRETLARTKPGVRILNCARGGLIDEQA 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L + L + H+ GAA+DVF EP P SPL + +NV+ TPH+G S+ +AQ N+ + Sbjct: 240 LYEFLLNGHVGGAALDVFEQEP-----PVDSPLLKLENVIFTPHLGASSYQAQANVARAI 294 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVL 351 A +++ Y G +AVNFP + + + + R G L Sbjct: 295 ATQIVDYLLYGIIRNAVNFPSIRPQDYEKIKPYLVLAERLGSL 337 >UniRef50_A3DM01 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=5 Tax=Archaea RepID=A3DM01_STAMF Length = 311 Score = 426 bits (1096), Expect = e-118, Method: Composition-based stats. Identities = 130/312 (41%), Positives = 185/312 (59%), Gaps = 10/312 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ +H+KALE LR+AG+ + +++L E I+D I +RS+ ++ VI Sbjct: 2 VKILVAAPLHEKALEKLRSAGFQIVYEEYP--SEDRLVELIKDVEAIIVRSKPKVSRRVI 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AAEKL I +G + +DLDAA ++GI VFNAP + T+SVAEL IG ++ +LR + A Sbjct: 60 EAAEKLKVIARAGVGLDNIDLDAANEKGIQVFNAPAAPTQSVAELAIGLMIDVLRKIAFA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILA-ESLGMYVYFYDIEN---KL 186 + K GVW K E RG LGIIG G IGT + +A GM + +YD+ + Sbjct: 120 DRKMREGVWAKKQCLGHELRGIVLGIIGMGRIGTAVARIAYHGFGMKIIYYDVRRCPKDV 179 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + L LL +D+VS+HVP PSTK+++ +++ LMK ++LIN +RG VVD Sbjct: 180 EKELDAKCVDLETLLKTADIVSIHVPLVPSTKHLINEEKLRLMKKSAILINTARGGVVDT 239 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL AL +AGA +DVF EP P PL + DNV+LTPHIG +T EAQE G+ Sbjct: 240 DALVKALKEGWIAGAGLDVFEEEPL----PPNHPLTKLDNVVLTPHIGANTVEAQERAGI 295 Query: 307 EVAGKLIKYSDN 318 EV K+I++ Sbjct: 296 EVVEKIIEFFKG 307 >UniRef50_B0TAQ8 D-3-phosphoglycerate dehydrogenase n=4 Tax=Clostridia RepID=B0TAQ8_HELMI Length = 526 Score = 425 bits (1095), Expect = e-117, Method: Composition-based stats. Identities = 112/370 (30%), Positives = 189/370 (51%), Gaps = 15/370 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 ++ L+ + + QK ++ L +AG ++ K L ++Q+ E I + + +RS T +T+ +I Sbjct: 1 MRVLVCDPISQKGIDVLTSAGDVAVDV-KLKLTEDQIVEIIAEYDAVVVRSETKITKRII 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA++L AIG +G + +D++AA ++GI V NAP NT + AEL + +L + R V A Sbjct: 60 EAADRLKAIGRAGVGVDNIDVEAATRKGIVVVNAPEGNTIAAAELTVAHILAIARNVGSA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 N G W++ E +GK LGI+G G IG+++ A + M V YD + Sbjct: 120 NLSLKGGKWDRSKYTGIELKGKTLGILGLGKIGSEVAKRARAFDMTVIAYDPYASVEKAK 179 Query: 191 --ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 V L + SD +++H+P+ T M+ A + ++MK G ++N +RG ++D A Sbjct: 180 SLGVTVTDLETVFRQSDFITVHMPKTKDTYRMISAAQFAIMKEGVRIVNCARGGIIDEQA 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L DA+ S +A A +DVF EP T SPL D V TPH+G ST+EAQ N+ ++V Sbjct: 240 LYDAIQSGKVAAAGLDVFEKEPCT-----DSPLFALDQVTATPHLGASTKEAQVNVAIDV 294 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVN-IAA 367 A +++ + +AVN P V + + ++ + + N I Sbjct: 295 AYDILRVLRGEAVSAAVNIPAVKQEMMTIFKPYL------NLVEKMGSYLGQTIGNRIEK 348 Query: 368 QYLQTSAQMG 377 + + Sbjct: 349 VAITFKGDVA 358 Score = 43.5 bits (102), Expect = 0.016, Method: Composition-based stats. Identities = 19/76 (25%), Positives = 29/76 (38%) Query: 334 LHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKA 393 G L+ H ++P ++ L I E VNIA +L G V + D V Sbjct: 448 APEGHMLVVPHTDKPRIIGQLGTIIGEHNVNIAGMHLGRKDFGGNAVAILTIDGPVPAAV 507 Query: 394 LQAMKAIPGTIRARLL 409 L + I G + + Sbjct: 508 LTDLAKIDGVADVKYV 523 >UniRef50_A5G1V9 D-3-phosphoglycerate dehydrogenase n=3 Tax=Proteobacteria RepID=A5G1V9_ACICJ Length = 528 Score = 424 bits (1092), Expect = e-117, Method: Composition-based stats. Identities = 116/323 (35%), Positives = 171/323 (52%), Gaps = 9/323 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K L+ + + A++ + G K L +L+E I + + +RS T +T +++ Sbjct: 2 PKVLISDKLSPAAIDIFKRRGIDVT--VKTGLAPAELREIIGEFDGLAIRSATKVTRELL 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +AA L IG IG + VD+ +A RG+ V N P+ N + AE IG + L R +PEA Sbjct: 60 DAATNLKVIGRAGIGVDNVDVKSATARGVVVMNTPYGNAITTAEHAIGLMFALARELPEA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKLPL 188 +A G W K E GK LG+IG G+IG+ + A L M V YD Sbjct: 120 SASTKAGKWEKNRFMGVELTGKTLGLIGAGNIGSIVADRALGLKMRVLAYDPYLTEARAT 179 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + L +L +D ++LH P T+N++ + I+ KPG +IN +RG +VD A Sbjct: 180 TLGVEKADLDTVLARADFITLHTPLTEQTRNILSRESIARTKPGVRIINCARGGLVDEAA 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L DAL S H+AGAA+DVF EPA SPL NV+ TPH+G +T EAQEN+ L+V Sbjct: 240 LYDALKSGHVAGAALDVFEVEPAKE-----SPLFALPNVVCTPHLGAATTEAQENVALQV 294 Query: 309 AGKLIKYSDNGSTLSAVNFPEVS 331 A ++ + G+ +A+N VS Sbjct: 295 AEQISDFLLTGAVTNAINMASVS 317 Score = 44.6 bits (105), Expect = 0.006, Method: Composition-based stats. Identities = 23/74 (31%), Positives = 41/74 (55%) Query: 336 GGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQ 395 G L + ++PG + + I AE+G+NIA +L + + G V I DE + + AL Sbjct: 453 GRHMLYVTNRDKPGFIAQCSAILAEKGINIATFHLGRTEKGGDAVCLISIDETLPDDALA 512 Query: 396 AMKAIPGTIRARLL 409 A++A+P ++A + Sbjct: 513 AIRALPQVMQATQI 526 >UniRef50_Q2G4V7 D-3-phosphoglycerate dehydrogenase n=146 Tax=cellular organisms RepID=Q2G4V7_NOVAD Length = 540 Score = 424 bits (1091), Expect = e-117, Method: Composition-based stats. Identities = 124/369 (33%), Positives = 188/369 (50%), Gaps = 11/369 (2%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K K L+ + + A G +++ G EQL I + + +RS T +T+ + Sbjct: 15 KPKVLISDKMDPNAARIFTEMG-CDVDVITGE-TPEQLIARIGEYDGLAIRSSTKVTKAI 72 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 ++AA L IG IG + VD+ AA+ +G+ V N PF N+ + AE I + L R +PE Sbjct: 73 LDAATNLKVIGRAGIGVDNVDIPAASAQGVVVMNTPFGNSITTAEHAIAMMFALARQIPE 132 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--ENKLP 187 ANA+ G+W K E GK LG+IG G+IG+ + A L M V +D + Sbjct: 133 ANAQTQAGLWPKNGFMGVEVTGKTLGLIGAGNIGSIVASRALGLKMKVVAFDPFLTPERA 192 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + + L LL +D ++LH P T+N++ + I+ K G +IN +RG +VD Sbjct: 193 VEMGVEKADLETLLAKADFITLHTPLTDQTRNILSRENIAKCKKGVRIINCARGGLVDEA 252 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL DAL S H+AGAA+DVF TEPA SPL N + TPH+G ST EAQ N+ L+ Sbjct: 253 ALKDALDSGHVAGAALDVFETEPAKE-----SPLFGTPNFICTPHLGASTTEAQVNVALQ 307 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAA 367 VA ++ + G +A+N P +S R + G L + ++ + IA Sbjct: 308 VAEQMADFLVTGGVTNALNMPSLSAEEAPKLRPYMALAEKLGSL--VGQLAHDNLTKIAI 365 Query: 368 QYLQTSAQM 376 + +AQ+ Sbjct: 366 EVEGAAAQL 374 >UniRef50_A9WCW3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A9WCW3_CHLAA Length = 525 Score = 420 bits (1082), Expect = e-116, Method: Composition-based stats. Identities = 131/352 (37%), Positives = 187/352 (53%), Gaps = 12/352 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ E + + L LR AG ++ LD L I + + +RS T +T +VI Sbjct: 3 RILVTEKIAAEGLAVLRQAGTVDVRLD---LDKPTLISIIGEYDALVVRSATKVTAEVIA 59 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A E+L IG G + +D++AA +RGI V NAP SN +VAEL IG L+ L R +P+A+ Sbjct: 60 AGERLRVIGRAGTGVDNIDVEAATRRGIIVVNAPASNNVAVAELTIGLLISLARRIPQAH 119 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN- 190 A G W + +E RGK LG++G G IG+++ A SL M V YD Sbjct: 120 ASLQSGRWARNDFVGWEVRGKTLGLVGLGRIGSEVARRARSLEMEVLAYDPVVSFDRAEQ 179 Query: 191 -ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 + L +L+ SDV+SLHVP ST+N+ + I MK G+ LINASRG +VD AL Sbjct: 180 LGVSLVTLDELVQRSDVISLHVPLIESTRNLFDQQRIMQMKRGAYLINASRGGIVDEVAL 239 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 +AL S HL GAA+DV+ EP P SPL ++ PHIG ST EAQ + G E+A Sbjct: 240 VEALNSGHLGGAALDVYNQEPL----PADSPLLGHPKIITVPHIGASTTEAQLSAGTEMA 295 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQ 361 ++ + G+ AVN P V+ ++ + N +L L ++ Sbjct: 296 EGVVTALNGGTPRYAVNAPFVAPEAWN---VLQPYLNLGRLLGTLVMQLVQE 344 Score = 43.1 bits (101), Expect = 0.019, Method: Composition-based stats. Identities = 16/70 (22%), Positives = 33/70 (47%) Query: 334 LHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKA 393 + G L+ H ++PG++ + ++ VNI+ Y+ A V+ + DE + Sbjct: 448 VPQGSLLITYHHDQPGMIGKVGQLLGAADVNISGMYVGRRAPRERAVMVLTLDEPAPPQV 507 Query: 394 LQAMKAIPGT 403 ++ + IPG Sbjct: 508 MEQIATIPGI 517 >UniRef50_Q6A895 D-3-phosphoglycerate dehydrogenase n=4 Tax=Actinomycetales RepID=Q6A895_PROAC Length = 417 Score = 420 bits (1080), Expect = e-116, Method: Composition-based stats. Identities = 198/400 (49%), Positives = 276/400 (69%), Gaps = 5/400 (1%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K LL+E +H +A+ +L+ AGY +E ALD++ L ++ +G+RSRT +T V+ Sbjct: 22 MKALLLENIHDEAVRTLKKAGYE-VERVSEALDEDDLISALDGVDLLGIRSRTRVTRRVV 80 Query: 71 NAA-EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 A +KL A+G FCIGTNQ+DLDA A+ G+P FNAP+SNTRSV ELV+ E++ L R + + Sbjct: 81 EACGDKLHAVGAFCIGTNQMDLDALAEAGVPAFNAPYSNTRSVVELVMAEIIALARRLGD 140 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 N + H GVW K A GS E RG++LGIIGYG+IG QL ++AE++GM V+FYDI + LP+G Sbjct: 141 RNTQMHNGVWRKSAIGSHEIRGRRLGIIGYGNIGQQLSVVAEAMGMQVFFYDIADVLPMG 200 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 NA + + +LL + VSLH+ PS +++G +E ++M+P SL +N SRG VVDI AL Sbjct: 201 NAHKCDSMEELLGSVETVSLHIDGRPSNTDLIGDREFAMMRPRSLFLNLSRGKVVDINAL 260 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 D L + H+AGA +DV+P EPA+ +PF SPL E DNV+LTPHIGGSTQEAQ +IG VA Sbjct: 261 VDNLRTGHIAGAGVDVYPEEPASGKEPFISPLREMDNVILTPHIGGSTQEAQVDIGRYVA 320 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQY 369 GKLI Y DNG+T +VN PE++ G R+ H+H N PGV+ LN++ A+QG N+ Q Sbjct: 321 GKLIDYVDNGATGMSVNIPEITPSPRTGARIGHLHRNVPGVMATLNRLVADQGGNVTYQA 380 Query: 370 LQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 L T ++GY ++DI + L + + GTIRAR+L Sbjct: 381 LATKGELGYCILDIA---ETDSGLLANVTVLEGTIRARIL 417 >UniRef50_A1RYE4 Glyoxylate reductase n=18 Tax=cellular organisms RepID=GYAR_THEPD Length = 339 Score = 419 bits (1079), Expect = e-116, Method: Composition-based stats. Identities = 101/325 (31%), Positives = 155/325 (47%), Gaps = 12/325 (3%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKG-ALDDEQLKESIRDAHFIGLRSRTHLTED 68 + K + + + L L+ + K E+L +IRD + + + Sbjct: 3 RPKVYVTRIIPEPGLSMLKECCDVVVHESKDWPPSREELLRNIRDKDALLCLLTDKIDAE 62 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 V++AA L I + +G + +D+ A KRGI V + P T +VAE +G +L + R + Sbjct: 63 VMDAAPNLKVISTYSVGFDHIDIPEATKRGIYVTHTPGVLTDAVAEFTVGLILAVTRRIV 122 Query: 129 EANAKAHRGVWNKLAAG----SFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 EA+ G W+K E +GK +G++G G IG S + + +YDIE Sbjct: 123 EADKIIRTGQWDKPWNPYFLTGPELKGKTIGLVGLGRIGVATAKRLSSFDVKILYYDIER 182 Query: 185 KLPLGNAT---QVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 + + + L LL SD+VS+HVP T +++ + + MK + LIN +RG Sbjct: 183 RWDVETVIPNMEFTDLDTLLEKSDIVSIHVPLTKETYHLINEERLRKMKKTAYLINTARG 242 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 VVD AL AL +AGAA+DVF EP P PL +FDNV+L PHI +T EA+ Sbjct: 243 PVVDTEALVKALKEGWIAGAALDVFEQEPL----PPNHPLTKFDNVVLAPHIASATIEAR 298 Query: 302 ENIGLEVAGKLIKYSDNGSTLSAVN 326 + + A LI + VN Sbjct: 299 QRMAELAARNLIAVLKGEMPPALVN 323 >UniRef50_P35136 D-3-phosphoglycerate dehydrogenase n=12 Tax=Bacillales RepID=SERA_BACSU Length = 525 Score = 418 bits (1076), Expect = e-115, Method: Composition-based stats. Identities = 110/368 (29%), Positives = 188/368 (51%), Gaps = 13/368 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + L+ + + L+ L + + I A +++L + +RS T +TED+ Sbjct: 2 FRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDEL----HTFDALLVRSATKVTEDLF 57 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 N L +G +G + +D+D A K G+ V NAP NT S AE + L+R +P+A Sbjct: 58 NKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEHTFAMISSLMRHIPQA 117 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 N WN+ A E GK LGI+G G IG+++ A + GM V+ +D Sbjct: 118 NISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAFGMTVHVFDPFLTEERAK 177 Query: 191 ATQV--QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 V + ++L +D++++H P TK ++ + I+ K G LIN +RG ++D A Sbjct: 178 KIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKTKKGVRLINCARGGIIDEAA 237 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +AL + H+AGAA+DVF EP ++ PL V+ TPH+G ST+EAQ N+ +V Sbjct: 238 LLEALENGHVAGAALDVFEVEPPVDNKLVDHPL-----VIATPHLGASTKEAQLNVAAQV 292 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 + ++++++ +SA+N P ++ + H + G L +++ E ++A Q Sbjct: 293 SEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGSL--VSQCMKEPVQDVAIQ 350 Query: 369 YLQTSAQM 376 Y T A++ Sbjct: 351 YEGTIAKL 358 Score = 47.3 bits (112), Expect = 0.001, Method: Composition-based stats. Identities = 13/76 (17%), Positives = 35/76 (46%) Query: 334 LHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKA 393 G + H++ GV+ + +I + +NIA + + G ++ + D + +K Sbjct: 447 YPTGHLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKI 506 Query: 394 LQAMKAIPGTIRARLL 409 ++ + +P + +L+ Sbjct: 507 VKELTNVPDIVSVKLI 522 >UniRef50_A7IAB7 D-3-phosphoglycerate dehydrogenase n=11 Tax=cellular organisms RepID=A7IAB7_METB6 Length = 534 Score = 418 bits (1075), Expect = e-115, Method: Composition-based stats. Identities = 114/321 (35%), Positives = 181/321 (56%), Gaps = 10/321 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ + + ++ L L+ A ++ K L +++L I + + +RS T +T VI Sbjct: 5 RILVSDPLAEEGLVILKEAFTVDV---KTDLKEDELCGVIGEYDALIVRSGTEVTAKVIT 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A +KL IG +G + VD+DAA ++G+ V NAP NT + E + +L L R +P+AN Sbjct: 62 AGKKLRFIGRAGVGVDNVDVDAATRQGVIVANAPEGNTLAATEHTMAMMLSLARNIPQAN 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--ENKLPLG 189 A + W + E K LGI+G+G IG ++ A ++ M YD + Sbjct: 122 ASLKKKEWKRSKFMGVELNEKTLGIVGFGRIGREVAKRANAMDMKCVAYDPFISKERAAQ 181 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 +V L++L ++DV+++H P TK+++ AK I+ MK G +IN +RG ++D AL Sbjct: 182 LGVRVMSLAELFTVADVITVHTPLIKETKHVINAKSIATMKDGVRIINCARGGIIDEAAL 241 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 DA+ S +AGAA+DVF TEP P SPL DNV++TPH+G ST EAQ+N+ ++VA Sbjct: 242 VDAIKSGKVAGAALDVFETEP-----PLESPLLSLDNVIVTPHLGASTVEAQKNVAIQVA 296 Query: 310 GKLIKYSDNGSTLSAVNFPEV 330 + ++ + GS VN P V Sbjct: 297 KQCVEVLNGGSAKYVVNAPIV 317 Score = 41.9 bits (98), Expect = 0.049, Method: Composition-based stats. Identities = 15/73 (20%), Positives = 35/73 (47%) Query: 334 LHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKA 393 + G ++ H ++PGV+ + I + +NIA + ++ + D +V E Sbjct: 452 IPEGYVIVSRHLDKPGVIGRASTILGKCNINIAGMQVGRINAGEEALMVLNVDSEVPEDV 511 Query: 394 LQAMKAIPGTIRA 406 ++ ++++PG A Sbjct: 512 MKEIRSMPGIFSA 524 >UniRef50_A2STQ1 D-3-phosphoglycerate dehydrogenase n=5 Tax=cellular organisms RepID=A2STQ1_METLZ Length = 527 Score = 418 bits (1075), Expect = e-115, Method: Composition-based stats. Identities = 116/345 (33%), Positives = 190/345 (55%), Gaps = 10/345 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K L+ + + + + L+ + K L +++L + I + + +RS T +T +I Sbjct: 3 FKVLVSDPLAAEGIAILKDFCEVD---EKADLSEDELVKIIGEYDALIVRSGTQVTARII 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA+K+ IG +G + +D +AA K+GI V NAP NT + E I ++ + R +P+A Sbjct: 60 EAADKMKYIGRAGVGVDNIDCEAATKKGIIVSNAPEGNTLAATEHTIAMMMAMARNIPQA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 +A +G W + E GK LG++G+G IG ++ A++L M V YD +G Sbjct: 120 SASLKKGEWKRSKFMGNEMNGKVLGVVGFGRIGREVAKRAQALQMTVIAYDPFIPAEVGA 179 Query: 191 A--TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 A ++ +++L +DV+++H P PST +++ + I+ MK G +IN +RG ++D Sbjct: 180 AMGVEMMSVAELFTKADVITVHTPLIPSTTHLVNKESIATMKTGVRMINCARGGIIDEKD 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L DA+ S +AGAA+DVF TEP T SPL + D+V++TPH+G ST EAQ+N+ + V Sbjct: 240 LYDAIVSGKVAGAALDVFETEPPTE-----SPLLKLDSVIVTPHLGASTVEAQKNVAISV 294 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTA 353 A + I GS SAVN P V+ + + + G L A Sbjct: 295 AHQCIDVLKGGSAKSAVNAPLVTPEVKSKIDPYALLAEKMGSLAA 339 >UniRef50_A5FRL7 D-3-phosphoglycerate dehydrogenase n=5 Tax=Dehalococcoides RepID=A5FRL7_DEHSB Length = 526 Score = 418 bits (1075), Expect = e-115, Method: Composition-based stats. Identities = 128/363 (35%), Positives = 186/363 (51%), Gaps = 18/363 (4%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + L L+ ++ K L E+L I + + +RS+T +T D+IN Sbjct: 3 KVLVSDALSATGLAPLKEIAQVDV---KTGLKPEELISIIGEYDALLVRSQTQVTADIIN 59 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A +KL IG +G + +DL AA GI V NAP NT S E + +L + R +P AN Sbjct: 60 AGKKLQVIGRAGVGVDNIDLKAATGNGIIVVNAPTGNTISATEHTLALMLAMARHIPRAN 119 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 A G W + E +GK LGI+G G+IG+++ A +L M V YD + Sbjct: 120 ASLKSGQWKRNEFVGSELKGKTLGIVGLGNIGSEIAKRALALEMRVIGYDPFISMERAKK 179 Query: 192 TQVQ--HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 QV+ DLL +D ++LHVP TK ++G KE+ +MKP LIN SRG ++D AL Sbjct: 180 LQVELLPFEDLLKQADFITLHVPMTGQTKGLIGPKELEMMKPTVRLINTSRGGIIDEEAL 239 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 A+ K + GAAIDVF EP T S L E DN+++TPH+G ST EAQE +V Sbjct: 240 AKAVKEKRIGGAAIDVFSKEPCTE-----SCLFECDNIIVTPHLGASTAEAQELATSDVV 294 Query: 310 GKLIKYSDNGSTLSAVNFPEV---SLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIA 366 ++I + AVN P + SLP+ G M + +++ L N+ Sbjct: 295 KQVIDVFEGRPARYAVNAPYISAESLPVVGP--FMPVARTVGSLVSQLTD---GHMKNVT 349 Query: 367 AQY 369 +Y Sbjct: 350 IKY 352 >UniRef50_UPI0001C41AB7 phosphoglycerate dehydrogenase SerA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41AB7 Length = 524 Score = 417 bits (1074), Expect = e-115, Method: Composition-based stats. Identities = 107/324 (33%), Positives = 179/324 (55%), Gaps = 11/324 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ + +++K +E+L+ ++ ++ E+L E+I + I +RSRT L +VI Sbjct: 1 MKALVADAINEKGIENLKEVCDVVVD---TSITPEELLETIGEYDAILIRSRTKLPAEVI 57 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A+ L I +G + VD++AA K+GI V NAP S + +VAE +G +L +R + A Sbjct: 58 EKADNLKIIARAGVGVDNVDVNAATKKGIMVVNAPESTSITVAEHTMGLILSTIRKIAIA 117 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + G W K A E R K LG+IG G IG+Q+ ++ M YD + Sbjct: 118 DKSTKAGKWEKKAFMGMELRNKTLGVIGMGRIGSQVVNRCKAFEMDAIAYDPYLPPEVAK 177 Query: 191 ATQV---QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 V + + D+L +D++++HVP P T++ + ++ +MK +L+ N +RG V+D Sbjct: 178 NMGVELYEDIEDVLTRADIITIHVPLTPETEHSISTEQFKMMKDTALIFNCARGGVIDED 237 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL +AL + + GA +DV+ EPATN + L E DN++ TPHI ST+EAQ + + Sbjct: 238 ALYEALVNGEILGAGLDVYEKEPATN-----NKLFELDNIVCTPHIAASTKEAQRDAAII 292 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVS 331 VA ++I G + +N P ++ Sbjct: 293 VANEVITLFKGGMPKNIINMPRMN 316 >UniRef50_D1JIG3 D-3-phosphoglycerate dehydrogenase n=1 Tax=uncultured archaeon RepID=D1JIG3_9ARCH Length = 542 Score = 416 bits (1071), Expect = e-115, Method: Composition-based stats. Identities = 107/344 (31%), Positives = 178/344 (51%), Gaps = 10/344 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + ++ ++ LR G ++E L E L I + + +RS T +T+++I+ Sbjct: 12 KVLVTDNISEEGIKKLREFGDVDVELD---LSKEDLAACIANYDALVIRSGTTVTKEIID 68 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A ++L IG +G + +D++ A ++GI V N+P +N+ S AE LL + R +P AN Sbjct: 69 AGKRLKVIGRAGVGVDNIDVERATEKGILVVNSPEANSISAAEHTFAMLLSISRKIPAAN 128 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 G W + E GK LG IG G +G+++ A+ GM V +D Sbjct: 129 VSLKSGKWERKKHMGVEVNGKVLGTIGLGRVGSEVAKRAKGFGMRVVAHDPFISAAKAKE 188 Query: 192 TQVQHL--SDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 + L ++L +D ++LH P T +M+G E LMK G +IN +RG ++D AL Sbjct: 189 LGITLLGFKEVLATADFITLHTPLTKDTHHMIGKGEFELMKDGVRVINCARGGILDEDAL 248 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 +A+ + +AGAA+DVF EP N D L E + V++TPH+G ST EAQ + +A Sbjct: 249 KEAIKAGKVAGAALDVFEQEPPNNDD-----LLELEEVIVTPHLGASTTEAQRAAAVVIA 303 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTA 353 ++I N +A+N + L + + + G+L+A Sbjct: 304 DEVIGALSNKPVKNALNMLYLEEELMDSVKPYLVLAEKLGLLSA 347 >UniRef50_B3DVF6 Phosphoglycerate dehydrogenase and ACT domains n=2 Tax=Verrucomicrobia RepID=B3DVF6_METI4 Length = 531 Score = 416 bits (1071), Expect = e-115, Method: Composition-based stats. Identities = 115/345 (33%), Positives = 172/345 (49%), Gaps = 8/345 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 L+ + + +K + L+A+ ++ K L +++L I D + +RS+T +T VI Sbjct: 6 HILIADPISKKGIAELQASAQLIVD-EKYGLKEDELARVIADYDGVIVRSQTKITRKVIE 64 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A +KL IG +G + VD+DAA ++GI V N P NT + AE LL L R V +A+ Sbjct: 65 AGKKLKVIGRAGVGIDNVDVDAATEKGIVVMNTPGGNTIATAEHTFSLLLALARNVAQAH 124 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE---NKLPL 188 A G W + E GK LGIIG G +G ++ A + GM V +D K+ Sbjct: 125 ASMQLGEWKRKNFEGIELYGKILGIIGLGRVGMEVAKRALAFGMKVKCFDPYLSPTKVKN 184 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 V L +L D +SLHVP T+ ++ + K G +IN +RG ++ I Sbjct: 185 LQVELVNSLDELFQDIDFLSLHVPLTQETEGIINKDNLKKCKRGIRIINCARGGLIRIAD 244 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L + L S +AGAA+DV+ EP P PL NV+LTPH+ ST EAQEN+G E+ Sbjct: 245 LEELLKSGWVAGAALDVYEPEPP----PADFPLRGLPNVVLTPHLAASTIEAQENVGTEI 300 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTA 353 A +I + +AVN P V + R + G+ + Sbjct: 301 AAMVIDVLCHNIIRNAVNVPSVDPKILSILRPYMALGEKLGIFMS 345 >UniRef50_B8CX87 D-3-phosphoglycerate dehydrogenase n=1 Tax=Halothermothrix orenii H 168 RepID=B8CX87_HALOH Length = 527 Score = 416 bits (1071), Expect = e-115, Method: Composition-based stats. Identities = 110/340 (32%), Positives = 173/340 (50%), Gaps = 8/340 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + K +E L L E+ + I + + +RS T + ++ ++ Sbjct: 3 KVLVSDNISPKGIEILEQEADVTF---NPDLSREEFLDIIGEYDGLIVRSMTEVDKEALD 59 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A L IG G + +D++ A+KRGI VFN P NT S E IG +L L R +P+AN Sbjct: 60 KARNLKVIGRAGTGYDNIDIEEASKRGIIVFNTPTGNTISAVEHTIGMMLALSRNIPQAN 119 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 H G+W++ E +GK LGIIG G IG+++ + A++ GM V D Sbjct: 120 QALHEGIWDRKKYMGVEVKGKTLGIIGLGRIGSRVAVRAQAFGMKVIANDPYLPPEKAAK 179 Query: 192 TQVQHL--SDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 V L ++L SD ++LH P T +++ KE ++MK +IN +RG VD AL Sbjct: 180 INVPLLGFKEVLKKSDYITLHTPLTDETYHILSHKEFAIMKDNVRIINCARGKNVDTQAL 239 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 ALA +AGAAIDV EP +P L D V++T H+GG+T EA +N+ + A Sbjct: 240 AKALAEHKVAGAAIDVHEVEPLPEDNPL---LKYQDRVIMTCHLGGTTTEAMDNVSIAAA 296 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPG 349 +++ +NG S +N P +++ + + N+ G Sbjct: 297 EQVLDVLNNGLPESPLNIPSINIQEYNKAKPYLNLVNKLG 336 >UniRef50_Q1IVI0 D-3-phosphoglycerate dehydrogenase n=3 Tax=Acidobacteria RepID=Q1IVI0_ACIBL Length = 531 Score = 414 bits (1066), Expect = e-114, Method: Composition-based stats. Identities = 109/323 (33%), Positives = 176/323 (54%), Gaps = 7/323 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K ++ E + + A++ + N+ EQL E ++ A + +RS + ++ Sbjct: 1 MKIVVAEKIAKAAIDLFKQDPTWNVVTPDQVAQKEQLLEQLKGADALIVRSAVFVDAAML 60 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A++L IG +G + ++L+AA ++GI V N P +N +VAE IG +L L R +P A Sbjct: 61 EHADQLRVIGRAGVGVDNIELEAATRKGIAVMNTPGANAIAVAEHTIGLMLALARFIPRA 120 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKLPL 188 H G W K + E RGK LGI+G G IG ++ A S GM + +D + Sbjct: 121 TETMHAGKWEKKSLQGTELRGKTLGIVGLGRIGLEVARRAASFGMTLVAHDPYVSPAIAH 180 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 ++ ++L ++D ++LHV P T NM+ A ++ MK G ++N +RG ++D A Sbjct: 181 DAKIRLADRDEVLAVADYITLHVGLTPQTANMINATTLATMKKGVRIVNCARGELIDDAA 240 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +A+ S H+ GAA+DVF EP SP NV+LTPHIGGST EAQ+ +G+++ Sbjct: 241 LAEAVKSGHVGGAALDVFTEEPLKA-----SPYHGVPNVILTPHIGGSTAEAQDAVGVQI 295 Query: 309 AGKLIKYSDNGSTLSAVNFPEVS 331 A ++ Y G +AVN P ++ Sbjct: 296 AHQVRDYLQRGVVQNAVNMPSLT 318 >UniRef50_B9L167 Phosphoglycerate dehydrogenase SerA n=2 Tax=Thermomicrobia (class) RepID=B9L167_THERP Length = 745 Score = 413 bits (1062), Expect = e-114, Method: Composition-based stats. Identities = 116/349 (33%), Positives = 182/349 (52%), Gaps = 10/349 (2%) Query: 6 LEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 + + + ++ + + Q+A E L + D L E++R+A + +RS T + Sbjct: 197 AQPRRRRIVVSDVIDQRARERLASEADV---IEVDGRDKPALYEALREADALIVRSETQV 253 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 T +++ A +L + G + +DL AA + GI V NAP +N S E + +L + R Sbjct: 254 TRELLAHAPRLRVVARAGTGVDNIDLQAATEAGILVLNAPGANAVSAGEHTVALMLAIAR 313 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 + +ANA H G W + F+ +GK +GI+G G +G+ + + + YD Sbjct: 314 NLIDANATTHAGRWERKRFRPFDLKGKTIGIVGLGRVGSVVAQRLRAFECRLLGYDPYIT 373 Query: 186 LPLGNATQVQHLS--DLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 V+ + LL SD+V+ HVP P T++M+ A+ I+ MKPG+++IN +RG V Sbjct: 374 RERFAQLGVEPVDYETLLENSDIVTFHVPATPETRHMLDARAIARMKPGAIVINCARGEV 433 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 VD+ AL +AL S HLA A +DVFP EPA + SPL NV+LTPHIGGS++EA E Sbjct: 434 VDVQALAEALKSGHLAAAGVDVFPEEPA-----YQSPLFGLPNVVLTPHIGGSSREALEA 488 Query: 304 IGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLT 352 +G +A + +AVN P SL RRL + E ++ Sbjct: 489 VGEIIATTTLAALRGEIVPNAVNLPAASLHAPELRRLTRVAEAAGHLIA 537 Score = 45.0 bits (106), Expect = 0.005, Method: Composition-based stats. Identities = 22/81 (27%), Positives = 38/81 (46%), Gaps = 1/81 (1%) Query: 329 EVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADED 388 + PL G + H H +RPG++ + I VNIA + A+ G ++ + D+ Sbjct: 640 SLERPLAGHMLITH-HLDRPGIIGRIGTILGRYEVNIAGMQVGRRARGGEAIMVLNVDDP 698 Query: 389 VAEKALQAMKAIPGTIRARLL 409 + E AL + IP A ++ Sbjct: 699 IPEAALNEILQIPDVWTAYVV 719 >UniRef50_Q67TJ9 Phosphoglycerate dehydrogenase n=1 Tax=Symbiobacterium thermophilum RepID=Q67TJ9_SYMTH Length = 540 Score = 413 bits (1062), Expect = e-114, Method: Composition-based stats. Identities = 108/324 (33%), Positives = 172/324 (53%), Gaps = 13/324 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ E + + + LR ++ + E+L E I + + RS T +T +V+ Sbjct: 1 MKILVTEAISETGISLLRDEHEVDVR----KVTSEELLEIIPEYDALITRSETKVTAEVL 56 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +L +G +G + +D+ AA +RG+ V N P +NT S AE G L+ + R +P+A Sbjct: 57 ARGTRLKVVGRAGVGVDNIDVAAATERGVVVVNVPGANTYSTAEHAFGLLIAVARNIPQA 116 Query: 131 NAKA-HRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE---NKL 186 + G W++++ E GK LGIIG G IG+++ + A + GM V YD ++ Sbjct: 117 HHALAREGRWDRMSFVGTELHGKTLGIIGLGRIGSEVAVRARAFGMRVLAYDPYVPHSRA 176 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 T V L LL D +++H + P + ++GA E++LMKP + ++N +RG +VD Sbjct: 177 EHLGVTLVPSLRGLLPEVDFLTIHAAKTPESARLIGAAELALMKPTARIVNCARGGMVDE 236 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL AL LAGAA+DVF EP T SPL NV++TPH+ ST EAQ+ G Sbjct: 237 EALYRALKEGRLAGAALDVFAAEPCT-----DSPLFGLPNVVVTPHLSASTAEAQDANGR 291 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEV 330 +A +++ AVN P++ Sbjct: 292 YIAQYVLRALRGELVPEAVNLPQI 315 >UniRef50_O43175 D-3-phosphoglycerate dehydrogenase n=53 Tax=Bilateria RepID=SERA_HUMAN Length = 533 Score = 412 bits (1060), Expect = e-113, Method: Composition-based stats. Identities = 110/318 (34%), Positives = 161/318 (50%), Gaps = 9/318 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + + L+ G +E K L E+L ++D + +RS T +T DVIN Sbjct: 8 KVLISDSLDPCCRKILQDGGLQVVE--KQNLSKEELIAELQDCEGLIVRSATKVTADVIN 65 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AAEKL +G G + VDL+AA ++GI V N P N+ S AEL G ++ L R +P+A Sbjct: 66 AAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQAT 125 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--ENKLPLG 189 A G W + E GK LGI+G G IG ++ +S GM YD ++ Sbjct: 126 ASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSAS 185 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 Q L ++ + D +++H P PST ++ + K G ++N +RG +VD AL Sbjct: 186 FGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGAL 245 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 AL S AGAA+DVF EP P L + +NV+ PH+G ST+EAQ G E+A Sbjct: 246 LRALQSGQCAGAALDVFTEEP-----PRDRALVDHENVISCPHLGASTKEAQSRCGEEIA 300 Query: 310 GKLIKYSDNGSTLSAVNF 327 + + S VN Sbjct: 301 VQFVDMVKGKSLTGVVNA 318 >UniRef50_D1FX73 3-phosphoglycerate dehydrogenase-like protein n=1 Tax=Chironex fleckeri RepID=D1FX73_CHIFL Length = 520 Score = 412 bits (1059), Expect = e-113, Method: Composition-based stats. Identities = 97/335 (28%), Positives = 161/335 (48%), Gaps = 11/335 (3%) Query: 1 MAKVSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLR 60 MA ++++ + L+ + V + + N+++ G + E+L I+D + +R Sbjct: 1 MADLTIK----RVLISDKVDEVCKTIFESN-KINVDYRPG-ISKEELLAIIKDYDCLVVR 54 Query: 61 SRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGEL 120 S T +T +V +AA L +G G + +DL AA G+ V N P NT S AE + Sbjct: 55 SATKVTAEVFSAAPNLKLVGRAGTGVDNIDLKAATNNGVFVMNTPGGNTMSAAEHTCAMM 114 Query: 121 LLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 L R +P+ G W + E +GK LGIIG G IG ++ + ++ M Y Sbjct: 115 FSLARHIPQGYMSMQEGKWERSKFMGCELKGKTLGIIGLGRIGKEVALRMQACEMRTVGY 174 Query: 181 DI--ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINA 238 D + + L ++ + D +++H P P TK ++ AK K +IN Sbjct: 175 DPIVPKEAAAEFGVEFMELEEMWPIVDFITVHTPLIPQTKGLVNAKTFDKCKKTIRVINV 234 Query: 239 SRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQ 298 +RG ++D L DAL + AGA +DVF +EP + S L + V+ TPH+G ST Sbjct: 235 ARGGIIDESDLLDALNAGKCAGAGLDVFSSEPPSG---VVSELVKHPRVVCTPHLGASTA 291 Query: 299 EAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLP 333 EAQ + E+A +++ + + + VN P +S Sbjct: 292 EAQVRVAKEIAEQIVDACNGKTAVGLVNAPAISEA 326 >UniRef50_P73821 D-3-phosphoglycerate dehydrogenase n=40 Tax=Cyanobacteria RepID=SERA_SYNY3 Length = 554 Score = 412 bits (1059), Expect = e-113, Method: Composition-based stats. Identities = 105/330 (31%), Positives = 176/330 (53%), Gaps = 10/330 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + Q ++ L+ ++ K L + ++ + + + I LRS T +TE +I Sbjct: 31 KVLVSDSIDQVGIDILKQVAQVDV---KTGLSEAEIIDIVPEYDAIMLRSATKVTEKIIQ 87 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A +L IG +G + +D+ AA ++GI V N+P NT + AE + ++ L R +P+AN Sbjct: 88 AGSQLKIIGRAGVGVDNIDVPAATRQGIVVVNSPEGNTIAAAEHALAMMMALARHIPDAN 147 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 W + E K LG++G G IG+ + +A+++GM + YD + Sbjct: 148 KSVKESKWERKQFIGTEVYKKTLGVVGLGKIGSHVAGVAKAMGMKLLAYDPFISQERADQ 207 Query: 192 TQV--QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 L L + +D ++LH+P+ P T N++ A+ ++ MKP + +IN SRG ++D AL Sbjct: 208 IGCTLVDLDLLFSEADFITLHIPKTPETANLINAETLAKMKPTARIINCSRGGIIDEEAL 267 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 A+ + + GAA+DVF EP S L EF NV+LTPH+G ST+EAQ N+ ++VA Sbjct: 268 VTAIETAQIGGAALDVFAQEPLGE-----SRLREFSNVILTPHLGASTEEAQVNVAVDVA 322 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPLHGGRR 339 ++ SAVN P ++ + R Sbjct: 323 EQIRDVLLGLPARSAVNIPGLTPDVMEKLR 352 >UniRef50_B2V7I1 D-3-phosphoglycerate dehydrogenase n=8 Tax=Aquificales RepID=B2V7I1_SULSY Length = 529 Score = 411 bits (1057), Expect = e-113, Method: Composition-based stats. Identities = 114/320 (35%), Positives = 173/320 (54%), Gaps = 7/320 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + K LE L ++++ + +L E I+D I RSRT +T++++ Sbjct: 3 KVLVTDDISPKGLEILSNDEEIDLDYQP-EIKFNELLEIIKDYDAIITRSRTPVTKELLE 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AEKL IG +G + VDL+ A++RGI V N P +NT AE+ + L +LR + A+ Sbjct: 62 RAEKLKVIGRAGVGVDNVDLEEASRRGILVVNTPGANTIGAAEITMAHLYAVLRKLHLAH 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 G W + E GK +GIIG G++G+Q+ I ++ G V YD G+ Sbjct: 122 DSVKAGEWKRSKFMGEELDGKVVGIIGLGNVGSQVAIRCKAAGAKVIAYDPYIPKEKGDR 181 Query: 192 TQVQ---HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 V+ L +L+ +SD+++LH P T+NM+G KE LMK G IN +RG +VD A Sbjct: 182 LGVEIIDDLHELIKISDIITLHCPLTEETRNMIGKKEFDLMKKGVYFINCARGGIVDEDA 241 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L DA+ +AG +DVF EP D L EF N+ L+PHIG +T E+Q+N+ +++ Sbjct: 242 LYDAIQEGKIAGLGLDVFSKEPP---DERIRRLFEFPNISLSPHIGANTYESQDNVAIKI 298 Query: 309 AGKLIKYSDNGSTLSAVNFP 328 A +I AVN P Sbjct: 299 AQYVIAALKGQFVEVAVNAP 318 Score = 43.1 bits (101), Expect = 0.020, Method: Composition-based stats. Identities = 41/161 (25%), Positives = 68/161 (42%), Gaps = 23/161 (14%) Query: 269 EPATN--SDPFTSPLCEFD-NVLLTPHIGG--------STQEAQEN----IGLEVAGKLI 313 EP T F SP+ + N++ P I ST+EA N I + K Sbjct: 366 EPITAFFLKGFLSPILDTPVNIINAPFIAKERGVNIVKSTREAGLNFKEFIKVTARSKDK 425 Query: 314 KYSDNGSTLSAVNFPEVSL-------PLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIA 366 + S G+ L FP + + G LM +++ PGV+ L + A+ VNIA Sbjct: 426 EVSVGGTALYD-KFPRIMMVDNYWIDIEPQGVILMFENKDVPGVIGKLGTLLAKHNVNIA 484 Query: 367 AQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRAR 407 L + + ++ D+ + E+ L+ + IP I+A+ Sbjct: 485 GFRLGRLEKGKIALGALQLDDRLNEEVLEEIHQIPEIIKAK 525 >UniRef50_UPI0001C430A3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Bacillus pseudofirmus OF4 RepID=UPI0001C430A3 Length = 540 Score = 409 bits (1053), Expect = e-113, Method: Composition-based stats. Identities = 116/355 (32%), Positives = 187/355 (52%), Gaps = 13/355 (3%) Query: 3 KVSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSR 62 K + K L+ + + Q+ L L N+ + +D+ E + + +RS Sbjct: 11 KTTERTAKYHILVSDAMSQEGLLPLLENA--NVHCVEAYVDE---VEDLTQFDALLVRSA 65 Query: 63 THLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLL 122 T +TE+++ L + +G + +DLDAA K G+ V NAP NT S AE + Sbjct: 66 TKVTEELLQKMPNLKIVARAGVGVDNIDLDAATKHGVVVVNAPDGNTISTAEHTFAMISS 125 Query: 123 LLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI 182 LLR +P+ANA G WN+ A E RGK LGI+G+G IGTQ+ A + M + +D Sbjct: 126 LLRKIPQANASIKAGEWNRKAFQGSELRGKTLGIVGFGRIGTQIAKRARAFEMSLLVFDP 185 Query: 183 ENKLPLGNATQVQ--HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 V L D+L SD++++H P TK ++G + I+ K G LIN +R Sbjct: 186 FLTKARAEKIGVTPASLDDVLAQSDIITVHTPLTKETKGILGMENIAKTKQGVFLINCAR 245 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G ++D AL LA+ H+AGAA+DVF EPA + + L EFDNV+ TPHI ST+EA Sbjct: 246 GGIIDESALKHYLANGHIAGAALDVFEEEPAQDKE-----LLEFDNVIATPHIAASTKEA 300 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMH-IHENRPGVLTAL 354 Q N+ +V+ ++I++ + +++N P +S ++ + + + + +L+ + Sbjct: 301 QLNVASQVSEEVIRFLEGQPATNSINLPTLSKEIYEKIQPYYDLTKRMGNLLSQV 355 Score = 50.8 bits (121), Expect = 1e-04, Method: Composition-based stats. Identities = 23/87 (26%), Positives = 43/87 (49%), Gaps = 1/87 (1%) Query: 317 DNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQM 376 + G+ + ++N V + G L H ++PGV+ + ++ AE VNIA + + Sbjct: 447 EYGARIVSINGFNVDF-VPQGHLLYIQHNDKPGVIGRIGQLLAEHDVNIATMQVGRKQEG 505 Query: 377 GYVVIDIEADEDVAEKALQAMKAIPGT 403 G ++ I D+ V E L+A++ I Sbjct: 506 GEAIMMITVDKTVEEDVLKAVRKIEDI 532 >UniRef50_B7KZ64 D-3-phosphoglycerate dehydrogenase n=16 Tax=cellular organisms RepID=B7KZ64_METC4 Length = 535 Score = 409 bits (1051), Expect = e-112, Method: Composition-based stats. Identities = 114/329 (34%), Positives = 176/329 (53%), Gaps = 9/329 (2%) Query: 6 LEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKG-ALDDEQLKESIRDAHFIGLRSRTH 64 L + K K L+ + + A++ R G ++F G D E L I + +RS T Sbjct: 4 LTQTKPKVLITDALSDAAVQIFRDRGIE-VDFQPGLGKDKEALAAIIGQYDGLAIRSATK 62 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 +T+ ++ A +L IG IG + +D+ AA RG+ V N PF N+ + AE I + L Sbjct: 63 VTDKLLAQATRLKVIGRAGIGVDTIDVPAATARGVIVMNTPFGNSITTAEHAIALIFALA 122 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI-- 182 R +P A+A G W K E K LG++G G+IG + A L + V YD Sbjct: 123 RQIPAADASTQAGKWEKNRFMGVELTAKTLGVVGCGNIGAVVADRAIGLKLKVIAYDPFL 182 Query: 183 ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 + + L +LL +D+++LHVP T+N++ + ++ K G ++N +RG Sbjct: 183 TPERAFEIGVEKVELDELLARADIITLHVPLTDKTRNLLSEENLAKTKRGVRIVNCARGG 242 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 +VD AL AL S H+AGAA+DVF TEPA +PL NV+ TPH+G +T EAQE Sbjct: 243 LVDEIALRAALESGHVAGAALDVFVTEPAIE-----NPLFGHPNVICTPHLGAATSEAQE 297 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVNFPEVS 331 N+ L++A ++ Y +G+ +A+NFP +S Sbjct: 298 NVALQIAEQMADYLLSGAITNAINFPSIS 326 Score = 50.8 bits (121), Expect = 1e-04, Method: Composition-based stats. Identities = 26/120 (21%), Positives = 53/120 (44%), Gaps = 8/120 (6%) Query: 294 GGSTQEAQENIGLEVAGKLIK-----YSDNGSTLSAVNFPEVSLPLH-GGRRLMHIHENR 347 G S E+ I ++ A + + ++G + +++ L + +R Sbjct: 414 GASDYESVVRITVD-AEDMPRDAAGTVFNDGKPR-VIEIRGINIDAPFAPLMLYVRNHDR 471 Query: 348 PGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRAR 407 PG + + + E GVN+A + A+ G + + D +V+ + L+A++AIP R R Sbjct: 472 PGFVGSFGTVLGEAGVNLATFAMGREAEGGNAIAFVAVDAEVSPEVLKAIEAIPQVKRVR 531 >UniRef50_A8ZXY9 D-3-phosphoglycerate dehydrogenase n=6 Tax=Deltaproteobacteria RepID=A8ZXY9_DESOH Length = 532 Score = 408 bits (1050), Expect = e-112, Method: Composition-based stats. Identities = 114/370 (30%), Positives = 175/370 (47%), Gaps = 16/370 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ + + + L ++ K L E+LK I + +RS T +T D++ Sbjct: 3 MKVLVSDTIDASGVSRLENESGFAVDV-KTGLPPEELKSIIGQYDALIIRSATKVTADIL 61 Query: 71 NA-AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 A A KL A+ IG + VD+ AA K G+ V N P N + AE I ++ L R +P+ Sbjct: 62 EAGAPKLKAVARAGIGLDNVDIPAATKHGVAVMNTPEGNVVTTAEHTIAMMMALTRNIPQ 121 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--ENKLP 187 G W K E K LG+IG+G IG+ + A L M V +D Sbjct: 122 GTLSLRSGQWEKKKLQGREVFNKTLGVIGFGKIGSIVADRARQLKMNVIVFDPNIARTTI 181 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + L DL +D +++HVP+ T ++ MK G +++N +RG +VD Sbjct: 182 ENEGFEYVSLDDLFARADYITVHVPKLKQTVGLLNKAAFEKMKTGVMVLNCARGGIVDEA 241 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 L DAL S +A AA+DVF TEP P PL + DNV+ TPH+G ST+EAQ N+ Sbjct: 242 DLYDALMSGRVAAAALDVFVTEP-----PGEHPLLKLDNVIATPHLGASTKEAQVNVAEA 296 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRR-LMHIHENRPGVLTALNKIFAEQGVNIA 366 A ++I++ N + ++AVN P VS L + + +L + G NI Sbjct: 297 AAHQIIEFLKNNTVINAVNLPAVSGDLLEKLSPFTTLADRMGRLLAQFS------GANIT 350 Query: 367 AQYLQTSAQM 376 ++ + Sbjct: 351 EIKIEYNGDF 360 >UniRef50_B3RTC6 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RTC6_TRIAD Length = 520 Score = 408 bits (1050), Expect = e-112, Method: Composition-based stats. Identities = 104/321 (32%), Positives = 156/321 (48%), Gaps = 9/321 (2%) Query: 9 DKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 D K L+ + V K L A G L +L I + + +RS T +T + Sbjct: 3 DIRKVLISDSVDPKCKSVLEAKGIEVT--LNTKLSPAELVAEIPNYDGLIVRSATKVTAE 60 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 VI A + L IG G + +D+ AA + G+ V N P NT S AE ++ L R VP Sbjct: 61 VIKAGKNLKIIGRAGTGVDNIDIKAATECGVIVMNTPGGNTLSAAEHTCTLMVCLARQVP 120 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL 188 +A A G W++ E GK LGIIG G IG ++ +S G+ YD Sbjct: 121 QAAASMREGRWDRKKYMGIELMGKTLGIIGLGRIGREVATRMQSFGVRTVGYDPIVPAEA 180 Query: 189 GNATQVQ--HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 V+ L+DL D +++H P P T+ ++G + + K G +IN +RG ++D Sbjct: 181 AKEFDVEFFELNDLWPECDFITVHTPLIPQTRGLLGDETFAKCKKGVRVINCARGGIIDE 240 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL AL S AGAA+DVF EP N++ L + NV+ H+G ST EAQ + + Sbjct: 241 AALLRALQSGQCAGAALDVFEQEPPQNTE-----LVQHPNVIPVCHLGASTVEAQSRVAV 295 Query: 307 EVAGKLIKYSDNGSTLSAVNF 327 E+A + + +++ S A+N Sbjct: 296 EIAEQFVDFNEGKSLFGAINA 316 >UniRef50_Q4L766 D-3-phosphoglycerate dehydrogenase n=3 Tax=Staphylococcus RepID=Q4L766_STAHJ Length = 532 Score = 408 bits (1049), Expect = e-112, Method: Composition-based stats. Identities = 109/324 (33%), Positives = 171/324 (52%), Gaps = 8/324 (2%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K L+ + + L+SL N++ K LD++ L + I D + +RS+T +T+ V Sbjct: 2 KHNILVSDPISTDGLQSLLNHSDFNVDI-KTDLDEQSLLDIIGDYEGLIVRSQTQVTQQV 60 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I A L I +G + +D+DAA +GI V NAP NT S E + +L + R +P+ Sbjct: 61 IEKASNLKVIARAGVGVDNIDIDAATLQGILVINAPDGNTISATEHSVAMILAMARNIPQ 120 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKLP 187 A+A WN+ A E K LG+IG G IG + +S GM V YD Sbjct: 121 AHASLKNKEWNRKAFKGVELYQKTLGVIGAGRIGIGVAQRLQSFGMKVLAYDPYLTEDKA 180 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 ++ + ++ +D V++H P P T+ ++ A S KP +IN +RG +++ Sbjct: 181 QQLGVKLATIDEIARQADFVTVHTPLTPKTRGIVNADFFSKAKPTLQIINVARGGIINED 240 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 L +AL + +A AA+DVF EP P SPL E D +++TPH+G ST EAQE + + Sbjct: 241 DLLNALNNNQIARAALDVFEHEP-----PTDSPLIEHDKIIVTPHLGASTIEAQEKVAVS 295 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVS 331 V+ ++I +NG+ AVN P++S Sbjct: 296 VSEEIIDILENGNVTHAVNAPKIS 319 Score = 42.7 bits (100), Expect = 0.024, Method: Composition-based stats. Identities = 14/68 (20%), Positives = 32/68 (47%) Query: 335 HGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKAL 394 +L+ H ++PG++ ++ +NIA+ L + Q G ++ + D+ V E + Sbjct: 453 PNAYQLVSYHGDKPGMVGLTGQLLGRHNINIASMSLGRNIQGGQAMMVLSIDQPVTEDII 512 Query: 395 QAMKAIPG 402 + + G Sbjct: 513 NELYDVGG 520 >UniRef50_C4V410 Phosphoglycerate dehydrogenase n=4 Tax=Veillonellaceae RepID=C4V410_9FIRM Length = 565 Score = 407 bits (1048), Expect = e-112, Method: Composition-based stats. Identities = 106/335 (31%), Positives = 168/335 (50%), Gaps = 10/335 (2%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 ++K L +G+ + + L ++ + E+L + I D + +RS + +T DV Sbjct: 39 RMKILAADGISPEGIGLLT---DYEVDVRD-KISHEELLDVIGDYDALMVRSASKVTADV 94 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 + A KL IG +G + +D+ AA +RGI V N+P NT + E + +L + R +P Sbjct: 95 LERAGKLKIIGRAGVGVDNIDVKAATERGIIVINSPGGNTIAATEHTVAMMLAMARNIPT 154 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKLP 187 A+A H G WN+ A E RGK LG+IG G IG + A + M V YD + Sbjct: 155 ADATMHAGQWNRKAYVGVELRGKTLGVIGMGRIGGGVAKRALAFDMNVIAYDPYINEERA 214 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 V L D++ +D +++H+P T+ M+ ++ MK G L+N +RG +++ Sbjct: 215 KALGVTVGTLDDIIEQADFITVHMPLTKETRGMISMAQMRRMKQGVRLVNCARGGIINEH 274 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 L +A+ +AGAAIDVF +EP SPL ++LTPH+G ST EAQ + ++ Sbjct: 275 DLAEAVREGIVAGAAIDVFESEPLAED----SPLRSVPGIVLTPHLGASTVEAQIGVSVD 330 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMH 342 VA + L+AVN VS + R Sbjct: 331 VAKGICAALRGEPVLAAVNMAPVSKEVMRVIRPYI 365 Score = 45.0 bits (106), Expect = 0.005, Method: Composition-based stats. Identities = 20/79 (25%), Positives = 41/79 (51%), Gaps = 1/79 (1%) Query: 332 LPLHGGRRLMHI-HENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVA 390 + + R++ H NRPGV+ + I G+NI++ + S + G ++ + D D++ Sbjct: 482 VDVDPHARILICPHINRPGVIGTIGSIMGAAGINISSMQVGKSDRKGMNIMVLTIDHDIS 541 Query: 391 EKALQAMKAIPGTIRARLL 409 + L + A+ G A+L+ Sbjct: 542 DDVLARVLAVEGIFDAKLV 560 >UniRef50_Q49YF7 D-3-phosphoglycerate dehydrogenase n=55 Tax=Bacillales RepID=Q49YF7_STAS1 Length = 538 Score = 407 bits (1046), Expect = e-112, Method: Composition-based stats. Identities = 107/322 (33%), Positives = 169/322 (52%), Gaps = 8/322 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + + L+SL + LD+ +L I D + +RS+T +TE +I Sbjct: 3 KILVSDPISPEGLKSLIDHNDFEV-VIDTELDEAELINQIADYQALIVRSQTQVTEAIIE 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AA L I +G + +D+DAA K G+ V NAP NT S E + +L + R +P+A+ Sbjct: 62 AAPNLKVIARAGVGVDNIDVDAATKHGVIVINAPDGNTISATEHSMAMILSMARNIPQAH 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 G W++ E K LG+IG G IG + A+S GM++ +D Sbjct: 122 QSLKDGKWDRKTYRGTELYNKTLGVIGAGRIGLGVAKRAQSFGMHILAFDPYLSEDKAKE 181 Query: 192 TQVQ--HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 V + ++ SD V++H P P TK ++G KP +IN +RG ++D AL Sbjct: 182 LNVTRATVEEIAEQSDFVTVHTPLTPKTKGIVGKAFFEKAKPNLQIINVARGGIIDEAAL 241 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 DAL + AAIDVF +EPAT SPL + +++TPH+G ST EAQE + + VA Sbjct: 242 VDALNQNQIQSAAIDVFESEPATE-----SPLVNHEKIIVTPHLGASTVEAQEKVAVSVA 296 Query: 310 GKLIKYSDNGSTLSAVNFPEVS 331 +++ +NG+ +A+N P+++ Sbjct: 297 NEIVDIFENGNVFNAINAPKMT 318 Score = 43.5 bits (102), Expect = 0.013, Method: Composition-based stats. Identities = 19/70 (27%), Positives = 34/70 (48%) Query: 338 RRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAM 397 +L+ H +RPG++ +I E G+NIA+ +L Q G ++ + D V + + + Sbjct: 455 HQLVINHNDRPGIVGRTGQILGEYGINIASMHLGRINQGGNALMILSIDHPVTDDVIDGL 514 Query: 398 KAIPGTIRAR 407 I G R Sbjct: 515 YEIEGFNLIR 524 >UniRef50_C0QYX0 D-3-phosphoglycerate dehydrogenase n=2 Tax=Brachyspira RepID=C0QYX0_BRAHW Length = 534 Score = 407 bits (1046), Expect = e-112, Method: Composition-based stats. Identities = 115/381 (30%), Positives = 196/381 (51%), Gaps = 17/381 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ + V++ + + + + +++L + I + + +RS+T +T +I Sbjct: 1 MKVLITDKVNECVKDII---ADVSEAVFLPTMSEDELVKVIGEYDALMVRSQTKVTRKII 57 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A + L IG +G + +D++AA ++GI V N+P NT + +E I +L + R + A Sbjct: 58 EAGKNLKIIGRAGVGVDNIDVEAATEKGIIVVNSPDGNTIAASEHTIALMLAVSRNIVPA 117 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI---ENKLP 187 WN+ E GK LG++G+G IG ++ +A ++GM V YD E + Sbjct: 118 AVSTKEAKWNRDKFTGNELLGKTLGVMGFGRIGRKVVHIALAIGMKVIVYDPFATEEIVQ 177 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 A L + L D +SLH+P+ P T N++ + MK +++IN SRG +V+ Sbjct: 178 KAGAVYETSLDEFLPKLDYLSLHIPKTPETNNIINKDNLCKMKNTAIIINCSRGGLVNEE 237 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 L +AL + +A AA+DVF EP + P + DN++LTPH+G ST+EAQ N+ L+ Sbjct: 238 DLKNALENGTIAAAAVDVFVNEPKIETCPLVE--YKKDNLILTPHLGASTKEAQINVALD 295 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVSLP-LHGGRRLMHIHENRPGVLTALNKIFAEQGVNIA 366 VA ++ + G T SAVN P ++ L + M I EN ++ Q N Sbjct: 296 VAKQIKQVLSGGYTESAVNIPSLNPEKLEPVKDYMKISENAGEMIM--------QTANGK 347 Query: 367 AQYLQTSAQMGYVVIDIEADE 387 + L+ +AQ + +DI+ E Sbjct: 348 IKSLEITAQGDLINLDIQPLE 368 >UniRef50_A7HDB1 D-3-phosphoglycerate dehydrogenase n=3 Tax=Proteobacteria RepID=A7HDB1_ANADF Length = 528 Score = 406 bits (1045), Expect = e-112, Method: Composition-based stats. Identities = 121/357 (33%), Positives = 178/357 (49%), Gaps = 8/357 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ + + +A+ L+ AG K L +QL+ + D + +RS T +T +++ Sbjct: 4 RVLVSDDLSPEAVRILQEAGLEV--DVKVGLKPDQLERIVGDYDGLAVRSATKVTAQLLD 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A +L IG +G + VDL AA +RG+ V N P ++ +VAEL + +L L R V A Sbjct: 62 KAARLKVIGRAGVGVDNVDLAAATRRGVVVMNTPGGSSITVAELALSMILALSRHVAAAT 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--ENKLPLG 189 G W K E G+ LG++G G+IG+ L A +LGM V +D + Sbjct: 122 GSVKAGKWEKKRFQGHELAGRTLGVVGIGNIGSVLVARAVALGMRVVAFDPFISAEAAAK 181 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 + L L +DVVS+HVP T++++ A + MK G+LL+N +RG +VD AL Sbjct: 182 LGASLVDLDTLWREADVVSIHVPLTDKTRHLVDATALGKMKKGALLVNCARGGIVDERAL 241 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 DAL S L GA +DVF EP P PL +NV+LTPHIG ST+EAQ + + VA Sbjct: 242 ADALRSGQLGGAGLDVFEQEPP----PADHPLYGLENVILTPHIGASTEEAQSAVAVAVA 297 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIA 366 +L Y G +AVN P + + + G L A V I Sbjct: 298 EQLADYLVRGVVRNAVNAPGLPPEVMEQLAPYLPLAQKLGALAAQLAPQGPSEVTIE 354 >UniRef50_C6PIV3 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Thermoanaerobacter italicus Ab9 RepID=C6PIV3_9THEO Length = 325 Score = 406 bits (1045), Expect = e-112, Method: Composition-based stats. Identities = 107/320 (33%), Positives = 158/320 (49%), Gaps = 10/320 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K LL E +H + L G I + +E L +RD I +RS+ +T+ +I Sbjct: 3 KVLLSEEIHPDGRKILEEKGIEII--TAPDVKEETLISMVRDVEAIIVRSKAKITKGIIE 60 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A KL I G + +D++AA ++GI V N P N+ SVAE I +L L + + + Sbjct: 61 NAPKLKIISRTGAGVDNIDVNAATEKGILVCNLPAVNSLSVAEHTIAMILHLAKQLSLMD 120 Query: 132 AKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIENKLPLG 189 G W + + S E GK LGI+G G+IG + LGM + YD K Sbjct: 121 QAVRNGNWEMRNSNISVEVEGKTLGIVGMGNIGILVAKKCHDGLGMKIVAYDPYVKEKFK 180 Query: 190 NATQ--VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + V L +L SD V+LH P+ P T+ M+ + I MKP + LIN +RGTV+D Sbjct: 181 DYDYRFVDSLEELFKESDFVTLHCPDIPETRGMITRELIYSMKPTAYLINVARGTVIDEQ 240 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL +AL K +AGA +DVF EP + + L +NV+L+PH T+EA + +E Sbjct: 241 ALIEALKEKRIAGAGLDVFQQEPPSRDN----ELLRLENVILSPHSAALTKEATVRMAVE 296 Query: 308 VAGKLIKYSDNGSTLSAVNF 327 +I Y + N+ Sbjct: 297 AVQAVIDYFEGRQPKYIYNY 316 >UniRef50_B5JEX5 D-3-phosphoglycerate dehydrogenase n=2 Tax=Verrucomicrobiales RepID=B5JEX5_9BACT Length = 545 Score = 406 bits (1044), Expect = e-112, Method: Composition-based stats. Identities = 102/327 (31%), Positives = 161/327 (49%), Gaps = 9/327 (2%) Query: 10 KIKFLLVEGVHQKALESLRA-AGYTNIE-FHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 +K L+ + + ++ L+ G+ +E + D + E + A I +RS + +T Sbjct: 13 PMKILVADKISSTGVDFLKQQEGFEVVEAYGTFKEDYSKFLELAKGAAAIIVRSDSKVTR 72 Query: 68 DVIN-AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 +V AA L A+G +G + +D +AA G+ V N P NT + AEL +L R Sbjct: 73 EVFEVAAPTLKAVGRAGVGVDNIDSEAATDFGVVVMNTPGGNTIATAELTFTHMLCGARP 132 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--N 184 VP+A G W++ G E K LG+ G G IG ++ A++ GM V YD Sbjct: 133 VPQAAQSMREGRWDRKIYGGSELFKKTLGVCGMGRIGAEVAKRAKAFGMKVLAYDPYLSG 192 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + L +L SD +++H+P +T+ M+ I+ MK G L N +RG ++ Sbjct: 193 AKAETMGVEQVELDELFRESDYITVHMPLTDATRGMIDDAAIATMKDGVRLFNCARGGII 252 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL L S +A A +DV+ +EP PF S + LTPH+G ST+EAQE++ Sbjct: 253 DEDALLRGLESGKVAAAGLDVYTSEPPAEDHPFRSQ----KTLNLTPHLGASTEEAQESV 308 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEVS 331 GLE+A + G +A+N P + Sbjct: 309 GLEIAESVTSVLRGGGIRNAINMPSLD 335 >UniRef50_A6C9V4 Phosphoglycerate dehydrogenase n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C9V4_9PLAN Length = 541 Score = 405 bits (1043), Expect = e-111, Method: Composition-based stats. Identities = 111/374 (29%), Positives = 178/374 (47%), Gaps = 18/374 (4%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ + + L+ L ++ G L E+++E+++ A I +RS T LTE+V+ Sbjct: 3 RVLITDNLSPAGLKILEDNPEIEVDIRSG-LSPEEVREALKSADGIIIRSATKLTEEVLK 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 +L AI +G + +D AA + GI V N P NT S AE I ++ L R + A Sbjct: 62 GQPRLKAIVRAGVGVDNIDRAAATREGIVVMNTPAGNTTSTAEQTIALMMALARNIGPAY 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI---ENKLPL 188 A G W + + GK L IIG G IG + A+ L M V YD + Sbjct: 122 ATMKEGKWERKKLTGTQVAGKTLAIIGLGRIGLSVAHRAQGLEMKVIGYDPFMSAERAAE 181 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + + +L+ D +++H P T++++ A+ I+ M+PG +IN +RG +V+ Sbjct: 182 YGIELYKEVDELVKHCDFLTVHTPLTDETRDLINAERIATMRPGVRIINCARGGIVNEDD 241 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L DAL S +AGAA DVF EP P L + N+L TPH+G ST EAQE + LE Sbjct: 242 LADALESGKVAGAACDVFTQEP-----PENRRLIDAPNMLATPHLGASTDEAQEMVALEA 296 Query: 309 AGKLIKYSDNGSTLSAVNFPEVS--------LPLHGGRRL-MHIHENRPGVLTALNKIFA 359 A + + A+N VS + G RL + + + G L ++ + Sbjct: 297 AEIISDFLTKNEIRHAINMIPVSGAEMADLKPHIELGHRLGLFLSQQTKGSLKSVQIQYR 356 Query: 360 EQGVNIAAQYLQTS 373 + + + + +S Sbjct: 357 GEVADKQTKLITSS 370 >UniRef50_B2IJN8 D-3-phosphoglycerate dehydrogenase n=6 Tax=Bacteria RepID=B2IJN8_BEII9 Length = 529 Score = 405 bits (1042), Expect = e-111, Method: Composition-based stats. Identities = 127/399 (31%), Positives = 197/399 (49%), Gaps = 27/399 (6%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + L+ + + + A+ + G D ++L E I + +RS T +T+ ++ Sbjct: 3 PRVLISDALSEAAVAIFKERGIEVDFQPDLGKDKDKLAEIIGQFDGLAIRSATKVTDKIL 62 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A L +G IG + VD+ AA +G+ V N PF N+ + AE I + L R +P A Sbjct: 63 EKATNLKVVGRAGIGVDNVDIPAATAKGVIVMNTPFGNSITTAEHAIALMFALARQIPSA 122 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--ENKLPL 188 +A G W K E K LGIIG G+IG+ + L M V +D + L Sbjct: 123 DASTQAGKWEKNKFMGVEITAKVLGIIGCGNIGSIVAERGVGLKMRVIAFDPFLTPERAL 182 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + L DLL +D ++LH P P TKN++ A+ ++ K G +IN +RG +VD A Sbjct: 183 DLGVEKVELDDLLARADFITLHTPLTPQTKNILSAENLAKTKKGVRVINCARGGLVDEEA 242 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L L S H+AGAA DVF TEPA +PL NV+ TPH+G ST EAQEN+ L+V Sbjct: 243 LRKLLDSGHVAGAAFDVFITEPAKE-----NPLFGHPNVVCTPHLGASTSEAQENVALQV 297 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 A ++ Y G+ +AVNFP ++ E P + + AE+ + A Q Sbjct: 298 AEQMSDYLTRGAISNAVNFPSIT------------AEEAPKLKPFI--ALAEKLGSFAGQ 343 Query: 369 YLQTSAQMGYVVIDIEADEDVAEKALQAM--KAIPGTIR 405 + ++ + + I + +V + ++A+ AI G +R Sbjct: 344 VIDSAIKK----VTITYEGEVGQLKIKALTASAIAGILR 378 Score = 47.3 bits (112), Expect = 0.001, Method: Composition-based stats. Identities = 25/113 (22%), Positives = 47/113 (41%), Gaps = 4/113 (3%) Query: 297 TQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNK 356 T E + +AG + + D + A+N ++ + + +E++PG + Sbjct: 419 TVET-DKSSHSIAGTV--FHDGKPRIIAINDIKIDAAV-APVMIYVSNEDKPGFIGRFAS 474 Query: 357 IFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 + VNIA L + G + +E D V E +KA+PG + + L Sbjct: 475 LLGNASVNIATFALGRDREGGSAIALVEVDGAVPESVQNEVKALPGVKKVKAL 527 >UniRef50_B1HVJ4 Phosphoglycerate dehydrogenase n=5 Tax=Bacillales RepID=B1HVJ4_LYSSC Length = 535 Score = 405 bits (1041), Expect = e-111, Method: Composition-based stats. Identities = 101/323 (31%), Positives = 170/323 (52%), Gaps = 8/323 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFH-KGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 I + + + + + LR ++ L E+L I D + +RS+T +T +V Sbjct: 8 INVFIADPLSEDGIFPLRQEQDLDLNIIVDTGLAPEELMTKIADVDVLLVRSQTTVTREV 67 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I AA+ L IG +G + +DL AA + GI V NAP NT S AE I + L R +P+ Sbjct: 68 IEAAKSLKLIGRAGVGVDNIDLTAATEHGIIVVNAPDGNTNSAAEHTIAMMTSLARHIPQ 127 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--ENKLP 187 A G W++ + E + K LG++G+G IG ++ A+ M V YD ++ Sbjct: 128 AFNTLKNGKWDRKSYVGVELKNKTLGVVGFGRIGVEVAYRAKGQRMNVMAYDPFLTDERA 187 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + ++ +D +++H P P T+N++ ++ ++MK G +IN +RG +++ Sbjct: 188 KELGVTKASVEEICEAADFITVHTPLLPETRNLINKEKFAMMKDGVRIINCARGGIINED 247 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 L DA+ + +AGAA+DVF +EPAT L V+ TPH+G ST EAQE++ ++ Sbjct: 248 DLYDAIVAGKVAGAALDVFVSEPAT-----DHKLLTLPQVIATPHLGASTIEAQESVAVD 302 Query: 308 VAGKLIKYSDNGSTLSAVNFPEV 330 V+ +IK+ G+ + VN P + Sbjct: 303 VSNDIIKFYKTGTVTNPVNMPSI 325 >UniRef50_Q1PZY1 Similar to D-3-phosphoglycerate dehydrogenase (PGDH) n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PZY1_9BACT Length = 535 Score = 404 bits (1039), Expect = e-111, Method: Composition-based stats. Identities = 121/393 (30%), Positives = 187/393 (47%), Gaps = 17/393 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + L+ + + E L+ AG ++ K L +L I+ + +RS T LT V+ Sbjct: 10 MLVLIADDLPDVCNEILQNAGVEVLK--KTGLKPPELDAVIKMCDGVIVRSNTKLTAPVL 67 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +EKL AI +G + +D+ AA K+GI V N P N S AE I L L R VP+A Sbjct: 68 EKSEKLKAICRAGVGVDNIDVPAATKKGIVVMNTPAGNIISTAEHTIALLCSLSRFVPQA 127 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 A G W K + GK GIIG G +G Q+ A +L M V YD + + Sbjct: 128 CASVKEGKWEKKKFTGQQLTGKTFGIIGLGRVGRQVAKRAAALEMKVIGYDPFITTEISS 187 Query: 191 ATQ---VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 V++L DLL +D +++HV N TKN++ +KE SLMK G +IN +RG V+ Sbjct: 188 QYNIHIVKNLRDLLAQADYITIHVTLNKETKNLITSKEFSLMKKGVQIINCARGGVICEE 247 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 L +A+ + +AGAA+DVF EP P + L + + V+ TPH+G ST+EAQ + +E Sbjct: 248 DLYNAIKTGQVAGAALDVFEEEP-----PKDNKLLQLEEVIATPHLGASTEEAQYAVAIE 302 Query: 308 VAGKLIKYSDNGSTLSAVNF-PEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIA 366 A ++ +AVN P + + + E LT +N I Sbjct: 303 AAEQMAAALTGKGYKNAVNLSPYSPEEYASLKSYLALAEKMGSFLTQIN------NAGIQ 356 Query: 367 AQYLQTSAQMGYVVIDIEADEDVAEKALQAMKA 399 + + ++ + I I D + +++ Sbjct: 357 TLDIVYTGEISHKNIRIVTDSLIVGLLKPSLEE 389 >UniRef50_UPI0001C31769 D-3-phosphoglycerate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31769 Length = 541 Score = 403 bits (1036), Expect = e-111, Method: Composition-based stats. Identities = 112/331 (33%), Positives = 176/331 (53%), Gaps = 10/331 (3%) Query: 4 VSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRT 63 ++ E +++K L+ E + ++ LR ++ DE+ + + + H I +RS T Sbjct: 1 MTAETNRLKILVKEKLADSGVDLLREHFDVDL---GADWSDEEFRSRLPEYHGILIRSAT 57 Query: 64 HLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLL 123 LTE+ I L IG +G N VD+ AA +RGI V NAP SN + AE + LL L Sbjct: 58 KLTEEYIALGTNLRVIGRAGVGVNNVDVPAATRRGIVVANAPQSNVVTAAEHTMALLLSL 117 Query: 124 LRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE 183 R VP+A+ W + G E K LG++G+G IG + A+ GM V +D Sbjct: 118 ARNVPQAHRSLTDHRWERSKFGGVEVYEKTLGVVGFGRIGQLVAERAKGFGMKVVAFDPF 177 Query: 184 NKLPLGNATQVQHLS---DLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 V+ D+ ++D +++H+P P T+ + A+ + MK G ++N +R Sbjct: 178 VGAERYRDLGVEKADTSADVYKVADFITIHLPVTPETQGWLNAEAFAQMKDGVRIVNCAR 237 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G +VD AL DAL S +AGAA+DVFP+EP T+ F + NV++TPH+G ST EA Sbjct: 238 GELVDDAALKDALDSGKVAGAALDVFPSEPITDYPLFD----GYANVVVTPHLGASTAEA 293 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVNFPEVS 331 Q+ G++ A ++I G+ +AVN P ++ Sbjct: 294 QDRAGVQTAEQVIAALTGGTVTTAVNIPAIA 324 >UniRef50_Q5WGX7 D-3-phosphoglycerate dehydrogenase n=8 Tax=Bacillaceae RepID=Q5WGX7_BACSK Length = 533 Score = 401 bits (1032), Expect = e-110, Method: Composition-based stats. Identities = 115/378 (30%), Positives = 199/378 (52%), Gaps = 15/378 (3%) Query: 1 MAKVSLEKD-KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGL 59 M +V+ K + L+ + + ++ L L A + +E + ++D+ E + + Sbjct: 1 MNQVAEPKTAQFHILVADTMSEEGLLPLLEADH--VEVTQASVDNAGPLEQ---YDALLI 55 Query: 60 RSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGE 119 RS T +TE++++ +L + +G + VD+ AA K G+ V NAP NT S AE Sbjct: 56 RSATTVTEELLSRMPRLKIVARAGVGVDNVDIQAATKHGVVVINAPDGNTISTAEHTFAM 115 Query: 120 LLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYF 179 + LLR +P+ANA G W++ A E RGK LGI+G+G IGTQL A++ M V Sbjct: 116 MCALLRNIPQANASVKSGKWDRKAYQGTELRGKTLGIVGFGRIGTQLAKRAKAFEMGVLV 175 Query: 180 YDIENKLPLGNATQVQ--HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLIN 237 YD + L +L+++D++++H P TK ++ + I+ KPG LIN Sbjct: 176 YDPFLTAERAEKLGIAQGELDHVLSVADIITVHTPLTKDTKGLLNMETIAKTKPGVFLIN 235 Query: 238 ASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGST 297 +RG ++D AL L + H+AGAA+DVF EPAT+ + L +V+ TPHI ST Sbjct: 236 CARGGIIDEQALKHYLNNGHVAGAALDVFTEEPATDKE-----LIGHPSVVATPHIAAST 290 Query: 298 QEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKI 357 +EAQ N+ +V+ +++++ + L+++N P +P ++ ++ + + L+++ Sbjct: 291 KEAQLNVAAQVSQEVLQFLNGEPALNSINLPA--MPKDVYEKIKPYYDLARTMGSVLSQL 348 Query: 358 FAEQGVNIAAQYLQTSAQ 375 I Y T+A+ Sbjct: 349 MRIPVQEIEVFYSGTTAE 366 >UniRef50_A7HM61 Glyoxylate reductase n=6 Tax=cellular organisms RepID=A7HM61_FERNB Length = 317 Score = 401 bits (1032), Expect = e-110, Method: Composition-based stats. Identities = 86/321 (26%), Positives = 158/321 (49%), Gaps = 11/321 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 ++ + + +K + L+ ++ + L E++ + A I + R + ++ I Sbjct: 1 MRVFVTYAIPEKGINMLKERFEVDVYTGEEFLSKEEMIKRAEYADAIVTQLRDPIDKEFI 60 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 + +K I + +G N +D++AA +RGI V N P T + A++ +L + R + E+ Sbjct: 61 YSLKKAKIIANYAVGYNNIDIEAAKERGIYVTNTPGVLTEATADIAFALILAVARRIVES 120 Query: 131 NAKAHRGV---WNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI---EN 184 + G W ++ GK LG+IG G IG + A GM + +Y+ Sbjct: 121 DKFVREGKFVGWKPKLFLGYDLYGKTLGVIGMGRIGQAVARRALGFGMNIVYYNRNRLPE 180 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 ++ + ++ +L+ +SD +SLH P T +++ + I+ MKP ++L+N +RG VV Sbjct: 181 EIEKQYNAKYVNIDELVEISDYISLHTPLTKETYHLINKERIAKMKPNAILVNTARGPVV 240 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL +AL + +AGA DV+ EP L + DNV+L PHIG +T E ++ + Sbjct: 241 DEQALYEALKERRIAGAGFDVYENEPVLTPG-----LEKLDNVVLLPHIGSATYETRDKM 295 Query: 305 GLEVAGKLIKYSDNGSTLSAV 325 VA +++ D + V Sbjct: 296 SEIVAINVMEALDGKRPSNCV 316 >UniRef50_C1ZMC1 D-3-phosphoglycerate dehydrogenase n=2 Tax=Planctomycetaceae RepID=C1ZMC1_PLALI Length = 546 Score = 401 bits (1031), Expect = e-110, Method: Composition-based stats. Identities = 100/334 (29%), Positives = 168/334 (50%), Gaps = 8/334 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ + + L+ L+ ++ KG L ++++ ++ DA I +RS T LT +++ Sbjct: 3 RVLITDNLSPAGLKILKETPGIEVDLRKG-LTPDEVRVALHDADGIIIRSETKLTPEILK 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 +L AI +GT+ ++L AA + GI V N P NT S AE I ++ L R + A Sbjct: 62 DQPRLKAIVRAGVGTDNINLPAATREGIVVMNTPAGNTTSTAEHTIAMMMALSRNIAPAA 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE---NKLPL 188 +K GVW++ + + GK + I+G G IG + A L M V +D + Sbjct: 122 SKLRDGVWDRKSFTGTQLAGKSIAIVGLGRIGLAVARRAMGLEMKVLGFDPFMSVERAAE 181 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + + +++ D +++H P +P T N++GA+ ++ MK G +IN +RG +++ Sbjct: 182 QGIELYRDIDEMITKCDYLTVHTPLSPETTNLIGAERLAKMKKGVRIINCARGGIINEAE 241 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L A+ S H+ GAA+DVF EP P +PL + VL TPH+ ST EAQE + +E Sbjct: 242 LAQAIESGHIGGAALDVFVKEP----TPPDNPLLKLPQVLCTPHLAASTDEAQELVAVEA 297 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMH 342 A + + AVN +S R+ Sbjct: 298 AEIMAGFLVRHEVRHAVNMAPISSAEMADMRIYL 331 >UniRef50_B6YWH0 Glyoxylate reductase n=95 Tax=cellular organisms RepID=GYAR_THEON Length = 334 Score = 400 bits (1029), Expect = e-110, Method: Composition-based stats. Identities = 94/326 (28%), Positives = 154/326 (47%), Gaps = 14/326 (4%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K K L+ + + ++ LR + + + E L E +RD + + +V Sbjct: 2 KPKVLITRKIPENGIKMLREHFEVEVWEDEHEISREVLLEKVRDVDALVTMLSERIDAEV 61 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 +AA +L + + +G + +D++ A K G+ + N P T + A++ LL R + E Sbjct: 62 FDAAPRLKIVANYAVGYDNIDIEEATKMGVYITNTPDVLTNATADMAWVLLLATARRLIE 121 Query: 130 ANAKAHRGVWNKLA-------AGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI 182 A+ G W K ++ G+ +GI+G+G IG + A+ GM + + Sbjct: 122 ADKFVRSGEWKKRGVAWHPLMFLGYDVYGRTIGIVGFGRIGQAIARRAKGFGMRILYNSR 181 Query: 183 ENKLPLGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 K + + L +LL SD V L VP T +M+ + + LMKP ++L+N +R Sbjct: 182 TRKPEVEKELGAEFMPLDELLKESDFVVLVVPLTKETYHMINEERLKLMKPTAILVNIAR 241 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G VVD AL AL +AGA +DVF EP + + L DNV+L PHIG +T A Sbjct: 242 GKVVDTEALVKALREGWIAGAGLDVFEEEPYYHEE-----LFSLDNVVLAPHIGSATYGA 296 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVN 326 +E + VA LI + + + VN Sbjct: 297 REGMAELVARNLIAFKNGEVPPTLVN 322 >UniRef50_A5IMH3 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=7 Tax=cellular organisms RepID=A5IMH3_THEP1 Length = 308 Score = 399 bits (1026), Expect = e-109, Method: Composition-based stats. Identities = 101/307 (32%), Positives = 161/307 (52%), Gaps = 5/307 (1%) Query: 6 LEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 ++ + + + + + ++A + L + +E L+ ++L + I + + +RS T + Sbjct: 1 MKMARYRVHVNDPLDKEATQLLMSK--DELEVTSEHLEKDELMKIIPEIDVLVVRSATKV 58 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 T D+I A + L I IG + +D+ A ++GI + N P ++ SVAEL +G +L R Sbjct: 59 TADIIEAGKNLKIIARAGIGLDNIDVQKAKEKGIKILNTPGASAPSVAELAMGLMLACAR 118 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 + A G W K A E GK LG+IG+G+IG ++ A + GM + YD K Sbjct: 119 HIARATISLKEGKWEKKALNGKELLGKTLGLIGFGNIGQEVAKRALAFGMKIIAYDP-AK 177 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 + L L SD +SLHVP ST++++ + I+ MK G +++N +RG +D Sbjct: 178 PATDLPVEYVDLDTLFRESDFISLHVPLTESTRHIINRESIAKMKDGVIIVNTARGGTID 237 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL +AL S + A +DVF EP T D L DNV+ TPHIG ST EAQ +G Sbjct: 238 EEALYEALVSGKVYAAGLDVFEVEPPT--DEIRRKLLNLDNVVATPHIGASTDEAQNRVG 295 Query: 306 LEVAGKL 312 E+ K+ Sbjct: 296 TELVEKI 302 >UniRef50_B7P3M8 D-3-phosphoglycerate dehydrogenase, putative (Fragment) n=2 Tax=Coelomata RepID=B7P3M8_IXOSC Length = 473 Score = 398 bits (1025), Expect = e-109, Method: Composition-based stats. Identities = 104/345 (30%), Positives = 162/345 (46%), Gaps = 17/345 (4%) Query: 6 LEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 + K L+ + V ++ L G K +L ++I + +RS T + Sbjct: 1 MALAIKKVLISDAVDASCVKILENNGVQVT--LKTDFTKPELLQAIEGYDALIVRSATKV 58 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 T DVI A + L IG G + +D DAA ++GI V NAP NT S AEL ++ L R Sbjct: 59 TSDVIKAGQALKVIGRAGTGVDNIDCDAATRQGILVINAPGGNTLSAAELTCAMIVTLSR 118 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--E 183 +P A G W++ E GK L I+G G IG ++ + +S GM +D Sbjct: 119 EIPAATMSLKAGKWDRKTFMGNELYGKTLAIVGLGRIGKEVALRMQSFGMKTIGFDPIVP 178 Query: 184 NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 ++ + L ++ ++D +++H P P TK+++G + K G +IN +RG + Sbjct: 179 KEVSREFGVESMSLDEIWPLADYITVHTPLIPQTKDLIGKASLQKCKKGVKIINVARGGI 238 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 V+ L AL S H GA +DVF EP N+ L V+ TPH+G +T+EAQ Sbjct: 239 VNEDDLLAALESGHCGGAGLDVFLEEPPKNTQ-----LIAHPKVVCTPHLGANTKEAQLR 293 Query: 304 IGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRP 348 + E+A + + S S VN P +S + EN+P Sbjct: 294 VAQEIAEQFVDLSQGKSVPGVVNAPSLSQ--------TQVPENKP 330 >UniRef50_A5GES6 D-3-phosphoglycerate dehydrogenase n=12 Tax=Desulfuromonadales RepID=A5GES6_GEOUR Length = 541 Score = 398 bits (1023), Expect = e-109, Method: Composition-based stats. Identities = 105/331 (31%), Positives = 175/331 (52%), Gaps = 5/331 (1%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K ++ + V Q+ LE L+ ++ G L E+L I D I RS T + +D++ Sbjct: 1 MKVIVTDEVAQEGLELLKQDPRVELDIRLG-LKKEELLAIIGDYEVIITRSGTTVDKDLL 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +A +KL + +G + VD+D A+ +G+ V NAPF NT S AE + LL R + +A Sbjct: 60 DAGKKLKMVARAGVGIDNVDIDYASSKGVIVVNAPFGNTNSAAEHAMALLLSFCRNITKA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 NA G W + E +GK G+IG G +G ++ ++ V D + + Sbjct: 120 NASLKSGEWKRAPFTGVELKGKTAGVIGLGKVGGRVATRLKAFECDVLGCDPYIAVKRAH 179 Query: 191 --ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 ++ ++ D+++ H P N T+NM+G KEI++MK G +LINA+RG +++ A Sbjct: 180 DLGVKLVSHEEIYKNCDIITFHTPLNEETRNMVGEKEIAMMKDGVILINAARGGIINEQA 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +AL + GAA+DV+ EP + L D +++TPH+G +T EAQ N+ ++V Sbjct: 240 LLNALKGGKVFGAAMDVWSEEPPKSETL--KELISQDKLVVTPHLGANTFEAQINVAVDV 297 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRR 339 + +++ Y D +AVN P + L R Sbjct: 298 SKEILNYLDEQPLENAVNIPRFDMALMDQMR 328 Score = 45.8 bits (108), Expect = 0.003, Method: Composition-based stats. Identities = 14/77 (18%), Positives = 33/77 (42%) Query: 334 LHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKA 393 L+ +E+RPG++ + I +NIA+ L + G ++ + D V + Sbjct: 452 APAEHMLLLNYEDRPGMIGKIGTIMGAHSINIASMNLGRREEKGEAMVILSLDSAVPLEV 511 Query: 394 LQAMKAIPGTIRARLLY 410 ++ ++ R ++ Sbjct: 512 MEEVRIATEATFIRAIH 528 >UniRef50_B6KF90 D-3-phosphoglycerate dehydrogenase, putative n=3 Tax=Toxoplasma gondii RepID=B6KF90_TOXGO Length = 604 Score = 397 bits (1021), Expect = e-109, Method: Composition-based stats. Identities = 122/418 (29%), Positives = 204/418 (48%), Gaps = 30/418 (7%) Query: 1 MAKVSLEKD-----KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAH 55 MA+ + +K + + L+ + + Q ++ L + + + L +E+L + + Sbjct: 1 MAEATAQKRQKKHGRFRVLVCDPIDQAGMDILSSFADVDTKL---KLSEEELCRVVGNYD 57 Query: 56 FIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAEL 115 + +RS T +TE +I +KL IG +G + V +DAA +GI V N+P NT + AEL Sbjct: 58 GLMVRSGTTVTEKIIKHGQKLKIIGRAGVGVDNVCVDAATAQGIFVVNSPNGNTMAAAEL 117 Query: 116 VIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGM 175 +G ++ L R +P+A+A RG W + + K +GIIG G +GT + + +LGM Sbjct: 118 TLGLMMALARKIPQADASVSRGEWTRSKFMGRQLNQKTIGIIGLGQVGTHVARVCTALGM 177 Query: 176 YVYFYDIENKLPLGNATQVQH--LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGS 233 V YD A ++ L LL SD ++LHVP T++++ A ++ L+K + Sbjct: 178 EVLAYDPFINEEKAKAVGCRNVALETLLASSDFITLHVPLLDKTRHLINADKLKLIKKDA 237 Query: 234 LLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPA-TNSDPFTSPLCEFDNVLLTPH 292 +INASRG V+D A+ +AL + LAGAA+DVF E + +P N++LTPH Sbjct: 238 CIINASRGGVIDEKAVAEALMANELAGAALDVFEEEKEFSKDNPLIQAKANGRNIILTPH 297 Query: 293 IGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLT 352 IG ST EAQ N+ ++VA + + G SAVN V + + +H +L Sbjct: 298 IGASTLEAQHNVAVDVALQFREALLGGLPQSAVNLQCV----RSQQLVSLVHL--AEILG 351 Query: 353 ALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY 410 L ++ + +L+ + D+ + A G +R R + Sbjct: 352 RLCSKLVDEP--VETLHLKIRGSVDSANADVLL-----------LSAAQGVLRTRCDH 396 >UniRef50_O04130 D-3-phosphoglycerate dehydrogenase, chloroplastic n=43 Tax=Viridiplantae RepID=SERA_ARATH Length = 624 Score = 395 bits (1015), Expect = e-108, Method: Composition-based stats. Identities = 112/346 (32%), Positives = 175/346 (50%), Gaps = 10/346 (2%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K + L+ E + + + LR G + + L E LK+ + ++ + +RS T +T +V Sbjct: 82 KPRILVTEKLGEAGVNLLREFGDVDCSYD---LSPEDLKKKVAESDALIVRSGTKVTREV 138 Query: 70 INAAE-KLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 AA+ +L +G +G + VDL AA + G V NAP +NT + AE I L + R V Sbjct: 139 FEAAKGRLKVVGRAGVGIDNVDLQAATEHGCLVVNAPTANTVAAAEHGIALLASMARNVA 198 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL 188 +A+A G W + GK L ++G+G +GT++ A+ LGM V +D Sbjct: 199 QADASIKAGKWERSKYVGVSLVGKTLAVMGFGKVGTEVARRAKGLGMTVISHDPYAPADR 258 Query: 189 GNATQV--QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 A V ++ +D VSLH+P P+TK + + S MK G LIN +RG V+D Sbjct: 259 ARALGVDLVSFDQAISTADFVSLHMPLTPATKKVFNDETFSKMKKGVRLINVARGGVIDE 318 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL AL + +A AA+DVF EP + S L + +NV +TPH+G ST+EAQE + + Sbjct: 319 DALVRALDAGIVAQAALDVFCEEPPSKD----SRLIQHENVTVTPHLGASTKEAQEGVAI 374 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLT 352 E+A + + +AVN P V+ + + + G L Sbjct: 375 EIAEAVAGALKGELSATAVNAPMVAPEVLSELTPYIVLAEKLGRLA 420 >UniRef50_B0K2Z0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=3 Tax=Thermoanaerobacter RepID=B0K2Z0_THEPX Length = 324 Score = 395 bits (1015), Expect = e-108, Method: Composition-based stats. Identities = 103/323 (31%), Positives = 156/323 (48%), Gaps = 11/323 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K LL E +H + + L + L ++D I LR+R+ +T +VI Sbjct: 3 KVLLSEEIHPEGRKLLEGKFEIVT---APDTSQQTLISMVKDVDAIILRTRSKITREVIE 59 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A L I G + +D++AA ++GI V N P N SVAE I +L L + + + Sbjct: 60 NAPHLKIISRTGAGVDNIDVNAATEKGILVCNLPAVNNLSVAEHTIAMILNLSKQLSLMD 119 Query: 132 AKAHRGVW-NKLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIENKLPL- 188 G W + + S E GK LGI+G G+IG+ + LGM + YD K Sbjct: 120 KAVRSGNWGARNSNISVEIEGKVLGIVGMGNIGSLVAKKCHDGLGMKIVAYDPYVKEKFR 179 Query: 189 -GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + V +L SD V+LH P+ P T+ M+ + I MK + LINA+RGTV+D Sbjct: 180 GYDYKFVDTREELFKESDFVTLHCPDIPETRGMITRELIYSMKHTAYLINAARGTVIDEQ 239 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL +AL K +AGA +DVF EP ++ + L +NV+L+PH T+EA + +E Sbjct: 240 ALIEALKEKRIAGAGLDVFQQEPPSSDN----ELLRLENVILSPHSAALTKEATVRMAVE 295 Query: 308 VAGKLIKYSDNGSTLSAVNFPEV 330 +I Y + N+ + Sbjct: 296 AVQAVIDYFEGRQPKYIYNYKAL 318 >UniRef50_C9LMC8 Phosphoglycerate dehydrogenase n=1 Tax=Dialister invisus DSM 15470 RepID=C9LMC8_9FIRM Length = 530 Score = 394 bits (1014), Expect = e-108, Method: Composition-based stats. Identities = 108/319 (33%), Positives = 164/319 (51%), Gaps = 8/319 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K + V ++A E L +I + +D+++L + I + + RS+T +T++VI Sbjct: 2 FKIFITADVAKEAKEFLEKEFVVDI---RPNMDEDELCKVIGEYDAVITRSQTKITKNVI 58 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +AA L IG +G + +D+ A +GI V N P SNT + E + +L + R +P+A Sbjct: 59 HAATNLKVIGRAGVGIDGIDIPEATAKGITVVNTPESNTIAACEHTLALMLSITRYIPQA 118 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + G W++ + + K +GIIG G +G+ + ++ M YD L G Sbjct: 119 HQSIMEGRWDRKSFTGIQLLNKTVGIIGVGRVGSNVAKRLQAFNMKTIGYDPYIPLERGQ 178 Query: 191 --ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + L LL SD ++LH P TK M+GAKEI MK G ++NASRG V+DI A Sbjct: 179 QLGVDLVDLDTLLRESDYITLHTPLTEETKGMIGAKEIEKMKDGVRIVNASRGAVIDIDA 238 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +AL + +AGA IDV+ EP P +P NV LTPH+G ST EAQ + +V Sbjct: 239 LAEALKTGKVAGAGIDVWTNEPLK---PENNPFLGMKNVTLTPHLGASTVEAQTGVATDV 295 Query: 309 AGKLIKYSDNGSTLSAVNF 327 A + +AVN Sbjct: 296 ARGVADALHGEPVATAVNA 314 Score = 46.5 bits (110), Expect = 0.002, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 34/71 (47%) Query: 340 LMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKA 399 ++ HEN+PG++ ++ I + GVNI + S ++ + D+D+ L + Sbjct: 456 ILAPHENKPGMIGQMSGILGKAGVNINGMQVGASKDKNTNIMAVAIDKDIPSAILPVLAN 515 Query: 400 IPGTIRARLLY 410 I G +++ Sbjct: 516 IDGIHGITVIH 526 >UniRef50_B6H0R3 Pc12g10550 protein n=23 Tax=Fungi/Metazoa group RepID=B6H0R3_PENCW Length = 596 Score = 394 bits (1014), Expect = e-108, Method: Composition-based stats. Identities = 109/328 (33%), Positives = 170/328 (51%), Gaps = 7/328 (2%) Query: 6 LEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 L + K L+ E + L LR++ ++ KG L ++L + I D + +RS T + Sbjct: 4 LRASRPKVLVPEKLSPDGLALLRSS--LDVHERKG-LSADELLQIIPDYDALLVRSETKV 60 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 T V+ AA+ L + +G + VD++ A K GI V N+P N + AE I ++ + R Sbjct: 61 TATVLRAAKNLKVVARAGVGVDNVDVEEATKLGIVVVNSPSGNIGAAAEHTIALMMSMAR 120 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE-- 183 +PE+ A G W + E +GK L IIG G +G + LA+ LGM V D Sbjct: 121 KIPESCASLKDGKWERSKFVGVEVKGKTLSIIGLGKVGLTVARLAKGLGMNVNALDPYAS 180 Query: 184 -NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 + V L +LL +D +++H P ST+ M+ E++ +KPG+ ++N +RG Sbjct: 181 PAVAASASVALVSSLPELLASADFLTIHTPLIASTRGMIAEAELAQLKPGARVLNVARGG 240 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 D AL AL S HL+GAAIDVF +EP + L ++TPH+G ST EAQE Sbjct: 241 TFDEDALLAALESGHLSGAAIDVFTSEPPAPDS-SAARLIAHPRAVVTPHLGASTVEAQE 299 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVNFPEV 330 N+ ++V ++++ SAVN P + Sbjct: 300 NVSVDVCEQVLEILQGSLPRSAVNAPLI 327 >UniRef50_C1TPS0 Lactate dehydrogenase-like oxidoreductase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TPS0_9BACT Length = 318 Score = 393 bits (1010), Expect = e-108, Method: Composition-based stats. Identities = 86/320 (26%), Positives = 144/320 (45%), Gaps = 9/320 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K + + + L L G + + L + I D + + + + Sbjct: 3 KVYVCHKIPEAGLNLLNGKVEYRCWDGDGPVPRDLLLKEISDVDGVITMLTEKVDSEFFD 62 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A + + + +G N VD++ A RG+ + N P T + A++ G L+ R EA Sbjct: 63 NAPNVKVVSNYAVGYNNVDVEEATSRGVKITNTPGVLTEATADIAFGLLVAASRRFTEAE 122 Query: 132 AKAHRGVWNKLAAG---SFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKL 186 G W E GK LG+IG+G IG + A GM V ++ Sbjct: 123 RYLRSGKWTCWHPTMLLGREIFGKTLGLIGFGRIGKAVARRASGFGMKVIYHTPSGGPAT 182 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 G+ + ++L SD +SLH P N T+ ++G KE+ MKP ++L+N SRG VVD Sbjct: 183 DQGDGPRWVSFEEILEKSDYLSLHCPLNDRTRGLIGKKELERMKPDAVLVNTSRGPVVDQ 242 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 +L ++L + A +DV+ EP + D PL +NV++ PHIG +T+EA++ + Sbjct: 243 TSLYESLRDGVIGAAGLDVYDEEPISLED----PLLSLENVVMLPHIGSATREARDAMAT 298 Query: 307 EVAGKLIKYSDNGSTLSAVN 326 A ++ + + VN Sbjct: 299 MAASNMLDVLEGKEPRNPVN 318 >UniRef50_D2RMS7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RMS7_ACIFE Length = 529 Score = 393 bits (1010), Expect = e-108, Method: Composition-based stats. Identities = 103/325 (31%), Positives = 162/325 (49%), Gaps = 9/325 (2%) Query: 9 DKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 DK K ++VE + K +E L+A + K + E+L + + D I +RS T + E+ Sbjct: 2 DKKKVIVVERISDKGVEMLKAQPDLEVTV-KFDIPREELLKIVGDYDAIIVRSVTKVNEE 60 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 AA L +G G + +D++ A KRGI V N P +N S AE IG +L R Sbjct: 61 FYQAARNLKVVGRAGNGVDNIDIEGATKRGIIVVNTPEANVISAAEHTIGLMLASCRNTV 120 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE---NK 185 +A VW++ E K LGIIG G IGT + ++ M V YD ++ Sbjct: 121 KAQKMIESRVWDRKNLKGVELYHKTLGIIGLGRIGTLVTKRMQAFEMKVIAYDPYIPDSR 180 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 + + L DLL +DV+++H P+ T NM+G +E+ K G L+N +RG + + Sbjct: 181 FKRLGVEKCETLDDLLAKADVITIHTPKTEETINMIGKEELKKCKKGVRLVNCARGGLYN 240 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 A+ DA+ +A +DV EP SPL + +LTPH+G T EAQ+ +G Sbjct: 241 EQAVADAIKEGQVASIGLDVLVDEPKP-----ISPLIGLEQCVLTPHLGADTVEAQDKVG 295 Query: 306 LEVAGKLIKYSDNGSTLSAVNFPEV 330 + +A +++ + +AVN P + Sbjct: 296 ISIAQEVVNVLNGQMVPNAVNLPAL 320 Score = 40.8 bits (95), Expect = 0.099, Method: Composition-based stats. Identities = 12/70 (17%), Positives = 31/70 (44%) Query: 334 LHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKA 393 + ++ ++++PG++ + + VNIA + + G ++ + D V + Sbjct: 452 VPEHYMILAKNDDKPGMIGQMGTLLGAAHVNIANMQVARKPKTGNAMMIMTVDSPVEKAT 511 Query: 394 LQAMKAIPGT 403 LQ + + G Sbjct: 512 LQMIAGLDGI 521 >UniRef50_Q5HNI1 D-3-phosphoglycerate dehydrogenase n=73 Tax=Staphylococcus RepID=Q5HNI1_STAEQ Length = 531 Score = 393 bits (1010), Expect = e-108, Method: Composition-based stats. Identities = 104/325 (32%), Positives = 169/325 (52%), Gaps = 8/325 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K L+ + + + L+S+ +++ L + L I + +RS+T +TE +I Sbjct: 3 HKILVSDPISEDGLQSILKHPEFDVDIQTD-LSENDLVNMISTYDALIVRSQTQVTERII 61 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 NAA L I +G + ++++AA +GI V NAP NT S E + LL + R +P+A Sbjct: 62 NAATNLKVIARAGVGVDNINIEAATLKGILVINAPDGNTISATEHSVAMLLAMARNIPQA 121 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKLPL 188 + WN+ A E GK LG+IG G IG + A+S GM + +D Sbjct: 122 HQSLRNKEWNRKAFRGVELYGKTLGVIGAGRIGLGVAKRAQSFGMKILAFDPYLTEDKAK 181 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 Q+ + ++ SD V++H P P T+ ++G+ + K +IN +RG ++D A Sbjct: 182 SLDIQIATVDEIAEKSDFVTVHTPLTPKTRGIVGSSFFNKAKQNLQIINVARGGIIDETA 241 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +AL + + AAIDVF EP P SPL + D +++TPH+G ST EAQE + + V Sbjct: 242 LIEALDNNLIDRAAIDVFEHEP-----PTDSPLIQHDKIIVTPHLGASTVEAQEKVAVSV 296 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLP 333 + ++I+ G+ AVN P++ L Sbjct: 297 SEEIIEILTKGNVEHAVNAPKMDLS 321 Score = 43.8 bits (103), Expect = 0.011, Method: Composition-based stats. Identities = 13/68 (19%), Positives = 33/68 (48%) Query: 335 HGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKAL 394 +L+ H+++PG++ + G+NIA+ L + G ++ + D+ +E+ + Sbjct: 453 PNQYQLVTCHKDKPGIVGQTGNLLGSHGINIASMTLGRNDAGGDALMILSIDQQASEEVI 512 Query: 395 QAMKAIPG 402 + + G Sbjct: 513 KILNETSG 520 >UniRef50_C1SGT4 D-3-phosphoglycerate dehydrogenase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SGT4_9BACT Length = 544 Score = 392 bits (1007), Expect = e-107, Method: Composition-based stats. Identities = 103/351 (29%), Positives = 174/351 (49%), Gaps = 10/351 (2%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K K L+ + + Q + L++ ++ G + + LK+ I + I RS T +T ++ Sbjct: 3 KYKVLITDHISQDGVNILKSDKDIEVDIQAGIKNPD-LKKIIGNYDAIITRSGTTVTAEL 61 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I KL IG +G + VD++AA+ +GI V NAP NT + EL +G +L ++R +P Sbjct: 62 IENPGKLKIIGRAGVGLDNVDIEAASMKGIIVMNAPTGNTLAACELTMGMMLSVVRKLPL 121 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 AN G W++ + K L ++G G IG + ++ M V YD K Sbjct: 122 ANQVTKSGEWDRKRFMGIQLYQKTLAVVGLGRIGGNVAKRCKAFDMKVVAYDPYIKKSRA 181 Query: 190 NATQVQ---HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + V+ L + ++ +D+++ H P TKN++ EI+ MK G ++IN +RG +V+ Sbjct: 182 ESLGVELCNSLEEAISQADIITFHTPLTDETKNLITKDEIAKMKDGVVIINCARGGIVNE 241 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 L DA S + A +DVF +EP P P + +N+ +TPHIG +T E Q + + Sbjct: 242 LDLVDACKSGKVTAAGLDVFMSEP-----PVNHPFFDVENIYVTPHIGANTAEGQYGVAV 296 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGR-RLMHIHENRPGVLTALNK 356 +A +++ S +AVN P + L + + EN + L K Sbjct: 297 IIAEQVVNALHGRSYKNAVNIPFMKTQLPEDMQKYFELLENIGHMAAQLTK 347 >UniRef50_Q7UQL2 Phosphoglycerate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UQL2_RHOBA Length = 540 Score = 391 bits (1006), Expect = e-107, Method: Composition-based stats. Identities = 105/370 (28%), Positives = 173/370 (46%), Gaps = 14/370 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + L+++ + Q+ ++ L A+ E + L E+L++S+ + LRS +T + + Sbjct: 2 HRILVLDDIAQEGIDLLEASEGIEYEV-RTKLKGEELRQSLNEFDAAILRSGVTITPESL 60 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +L A+ +GT+ +D AA +RGI V N P NT S AE LL + R + A Sbjct: 61 EGNTRLRALVRAGVGTDNIDKPAATRRGIVVMNTPAGNTVSTAEHTFAMLLAMSRNIAAA 120 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI---ENKLP 187 N G W++ + GK LGI+G G IG ++ A++ M V +D +++ Sbjct: 121 NQSLVEGRWDRKKFMGTQVAGKTLGIVGMGRIGREVASRAQAFDMDVVAFDPFLTDDQAE 180 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 +V + D+L D +++H P P T+ ++G +++ +KPG +IN +RG + D Sbjct: 181 SLKVRRVATVDDMLPQIDYLTVHTPLTPETRGLIGMEQLEKVKPGLRIINVARGGIYDSE 240 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 A+ + L S L G A+DV+ EP T SPL V+ TPH+G ST+EAQ + +E Sbjct: 241 AMVEGLKSGKLGGVALDVYENEPCT-----DSPLFGMPGVVCTPHLGASTEEAQTQVAVE 295 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAA 367 L+ Y G +VN + R H N L G I Sbjct: 296 GIHLLLNYLRTGEIRHSVNVASLDPKTLAELR---GHLNVAHRLGLFLSQL--HGGGIDH 350 Query: 368 QYLQTSAQMG 377 L ++ Sbjct: 351 ARLTFRGEVS 360 >UniRef50_D2R855 D-3-phosphoglycerate dehydrogenase n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2R855_9PLAN Length = 542 Score = 391 bits (1005), Expect = e-107, Method: Composition-based stats. Identities = 104/331 (31%), Positives = 163/331 (49%), Gaps = 9/331 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+++ + Q+ L+ L AA E G L E+LK+S+ + RS +T + + Sbjct: 3 RILILDPIAQEGLDMLAAAPGIEYEVRTG-LKGEELKKSLAEFDGAICRSGVTITAESLE 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 ++ AI +GT+ +D +AA + GI V N P NT S AE +L L R V EA Sbjct: 62 GNRRMRAIARAGVGTDNIDKNAATRLGIVVMNTPTGNTLSTAEHTFTLMLALSRRVAEAY 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI---ENKLPL 188 K G W++ + K LGI+G G IG ++ A + M V +D + Sbjct: 122 HKLIGGKWDRKTFMGTQLADKTLGIVGLGRIGQEVAKRAIAFQMKVLGFDPFLSTEQAAK 181 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 +V+ + ++L D +++H P P T N++G E+ ++KPG LIN +RG + + A Sbjct: 182 LGIERVETVQEMLPRVDYLTVHTPLTPETTNLVGFPELEVLKPGVRLINCARGGIYNEDA 241 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L + L + + G A+DVF TEP P+ NVL TPH+G ST+EAQ+ + +E Sbjct: 242 LVEGLKTGKIGGVALDVFVTEPCDK-----HPIYGMPNVLCTPHLGASTEEAQQQVAIEA 296 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRR 339 LI + G AVN V + Sbjct: 297 VQLLINFFTTGEVRHAVNMASVDPKTLASIK 327 >UniRef50_A8A9G4 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=3 Tax=Archaea RepID=A8A9G4_IGNH4 Length = 308 Score = 390 bits (1003), Expect = e-107, Method: Composition-based stats. Identities = 120/308 (38%), Positives = 170/308 (55%), Gaps = 8/308 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ + VH LE LR G +E + A E LKE I+ + +RSRT + +VI Sbjct: 3 RALVTDKVHPAGLELLREKGIEVVEDLE-AYKPEVLKERIKGFDVLIVRSRTKVRREVIE 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AA+KL I G + +DL+AA ++GI V NAP + +VAELVIG +++L R + Sbjct: 62 AADKLKVIARAGSGLDNIDLEAAKEKGIKVVNAPDALKNAVAELVIGMMVVLARRAHYSY 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 K G W K+ FE GK LG++G+G IG ++ A++LGM V YD+ + Sbjct: 122 RKLLEGEWEKV--MGFELAGKTLGVVGFGRIGREVAKKAKALGMNVIAYDVVDLSETAKE 179 Query: 192 TQVQ---HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 V+ L +LL SDVVSLHVP T+NM+ I +MK G++LINA+RG V D A Sbjct: 180 MGVEFTQDLEELLRKSDVVSLHVPLTEQTRNMINRDRIKIMKDGAILINAARGEVADYSA 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +AL S L G +DV+P EP + + L T HIG T+EAQ LEV Sbjct: 240 LLEALESGKLWGVGLDVYPEEPPKSEELL--KLIRHPRTFATAHIGAQTEEAQRRTSLEV 297 Query: 309 AGKLIKYS 316 A ++++ Sbjct: 298 AQRILEAL 305 >UniRef50_B5YAK7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Dictyoglomus thermophilum H-6-12 RepID=B5YAK7_DICT6 Length = 316 Score = 388 bits (998), Expect = e-106, Method: Composition-based stats. Identities = 105/322 (32%), Positives = 160/322 (49%), Gaps = 15/322 (4%) Query: 11 IKFLLV----EGVHQKALESLRAAGYTN-IEFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 K L+ E + K E + G + L +E+++E IRD + + + Sbjct: 2 FKVLITPRSFEKIKDKFEEVFKEEGIEVMLNPFGRVLTEEEMRELIRDVDGLIV-GIDPV 60 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 T V+ A KL I + +G + +D+ A KR I V N P +N+ +VAEL +G ++ +LR Sbjct: 61 TSKVLKNANKLKVISKYGVGVDNIDILEAKKRNIVVTNTPGANSNAVAELTVGLIINVLR 120 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 + ++ K G W++ E K LG+IG G IG ++ L + + V +D Sbjct: 121 KINLSDKKTREGRWDR--FIGNELSEKTLGVIGTGSIGRRVIELLKGFNLRVLCFDKYPD 178 Query: 186 LPLGNATQV--QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 + +V L +LL SDVVS+HVP T +M+ KE+ +MK ++LIN SRG + Sbjct: 179 YEWASKEKVFYVTLDELLRSSDVVSIHVPLTEETYHMISEKELRMMKKNAVLINTSRGGI 238 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 VD AL L ++GA +DVF EP P SPL + DNV++T HIG T+EA N Sbjct: 239 VDEDALYRFLKEGRISGAGLDVFEKEP-----PQNSPLLQLDNVVVTSHIGAHTEEAVAN 293 Query: 304 IGLEVAGKLIKYSDNGSTLSAV 325 + L+ LS V Sbjct: 294 MAKLAVENLLLALKGREPLSRV 315 >UniRef50_UPI0000DB72A4 PREDICTED: similar to 3-phosphoglycerate dehydrogenase n=2 Tax=Apocrita RepID=UPI0000DB72A4 Length = 478 Score = 387 bits (996), Expect = e-106, Method: Composition-based stats. Identities = 109/361 (30%), Positives = 169/361 (46%), Gaps = 11/361 (3%) Query: 13 FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINA 72 L+ + V E L G K L E+L + +++ + +RS T +T DV Sbjct: 8 VLISDPVDACCGELLVRHGIPVT--TKYKLSKEKLIKELQNHEGLIVRSETKVTADVFAC 65 Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA 132 L +G G + +DL+AA ++G+ V N P N+ S EL + L R V +A Sbjct: 66 CPNLRVVGRAGTGVDNIDLEAATRKGVIVLNTPGGNSISACELTCALISNLARNVTQAVQ 125 Query: 133 KAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNAT 192 G W++ FE GK L ++G G IG ++ ++ GM V +D N Sbjct: 126 SLKDGRWDRKLYSGFELSGKTLAVLGMGRIGREVTRRMQAYGMRVIAFDPLLTSEDANYL 185 Query: 193 QVQ--HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 V+ L ++ M+D +++H P P TKN++ A ++ K G +IN +RG +VD AL Sbjct: 186 NVEKFSLDEIWPMADYITVHTPLIPQTKNLINATTLAKCKKGVRIINVARGGIVDEEALL 245 Query: 251 DALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAG 310 +AL S H AGAA+DVF EP NS L V+ TPH+G ST+EAQ+ + E+A Sbjct: 246 NALKSGHCAGAALDVFTEEPPKNS--VILELIAHPKVISTPHLGASTEEAQQRVAEEIAQ 303 Query: 311 KLIKYSDNGSTLSA----VNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIA 366 + + ST VN P +S + + VL + + G+N+ Sbjct: 304 QFL-VLAGRSTEYVITGIVNAPMLSAAISDENASWIELSKKLAVLVGILSGQTKNGLNLI 362 Query: 367 A 367 Sbjct: 363 N 363 >UniRef50_Q0B0Y6 D-3-phosphoglycerate dehydrogenase n=9 Tax=Bacteria RepID=Q0B0Y6_SYNWW Length = 530 Score = 387 bits (996), Expect = e-106, Method: Composition-based stats. Identities = 95/325 (29%), Positives = 165/325 (50%), Gaps = 11/325 (3%) Query: 9 DKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 ++ K ++ E + + +E L+ + ++ + E+L E I + +RS T + E+ Sbjct: 2 ERKKVIVSERIADEGIELLKTELEVD---YRDGISREELLEIIDQYDALIVRSVTQVDEE 58 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 +I A++L +G G + +D+D + G+ V N P SNT S AE I LL +R Sbjct: 59 LIRRAKRLKIVGRAGNGIDNIDVDVCTRYGVIVANTPDSNTISAAEQTISLLLSSIRNTA 118 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE---NK 185 A+ G W++ E GK +GI+G G IG+ + ++ M V YD + Sbjct: 119 WASEYLKGGTWDRKPFRGVELYGKTVGIVGLGRIGSMVATRLKAFNMRVIAYDPYISDER 178 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 A +++ L +L+ +D +++H P N T +M+ + + L K G ++N +RG ++ Sbjct: 179 FTRFGAEKMESLEELVKEADFITVHTPRNEETMHMIDERILGLAKEGVRVVNCARGGIIK 238 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL L SK + A +DVF EPA +PL +F +V++TPH+G T EAQ+ +G Sbjct: 239 EEALLKGLESKKVLSAGLDVFEKEPA-----IDNPLFQFKSVVVTPHLGADTFEAQKRVG 293 Query: 306 LEVAGKLIKYSDNGSTLSAVNFPEV 330 +A ++IK + VN P + Sbjct: 294 ENIAEQVIKALKGEIVPNLVNLPAM 318 Score = 41.5 bits (97), Expect = 0.050, Method: Composition-based stats. Identities = 17/71 (23%), Positives = 32/71 (45%), Gaps = 4/71 (5%) Query: 336 GGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ--YLQTSAQMGYVVIDIEADEDVAEKA 393 G L+ +E+RP V+ ++G+NIA +T + ++ I D V E Sbjct: 454 EGYLLVVENEDRPRVIGPFATALGDEGINIAGMKVARKTKGEKAIMI--INVDNKVEEPV 511 Query: 394 LQAMKAIPGTI 404 L+ + + G + Sbjct: 512 LEKLSQLDGIV 522 >UniRef50_Q3AQU0 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chlorobiaceae RepID=Q3AQU0_CHLCH Length = 538 Score = 387 bits (995), Expect = e-106, Method: Composition-based stats. Identities = 117/376 (31%), Positives = 191/376 (50%), Gaps = 15/376 (3%) Query: 7 EKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLT 66 ++ +K L+ + VH + L G+ E K +L ++L I D + + +RS T L Sbjct: 9 NENVMKVLITDSVHPQCGRLLLQHGFEVTE--KPSLSPKELHAIIADYNILIVRSATSLP 66 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 +V+ A +L IG G + +DL+AA ++GI V + P N S AE LL R Sbjct: 67 AEVLAKATQLELIGRAGTGVDNIDLEAATRQGIVVMSTPGGNAVSAAEHTCAMLLAAARH 126 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--EN 184 +P+A A +G WNK E GK L +IG G +G ++ + ++ GM YD + Sbjct: 127 IPQAMADLKQGNWNKHLYAGIELEGKTLSLIGLGRVGREVAMRMQAFGMRTIAYDPAIAD 186 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + ++ L + L +DV+++H + ST N++G + +SL KPG +++N +RG ++ Sbjct: 187 EDAALLDIELLPLHENLLRADVITIHSALDESTYNLLGKETLSLTKPGVIIVNCARGGII 246 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 + AL +ALAS H+A AA+DVF EP T PL +F V+ TPHI ST E QE + Sbjct: 247 NEVALAEALASGHVAAAALDVFTKEPIAA----THPLLQFPQVIATPHISASTAEGQEKV 302 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEVSLP-LHGGRRLMHIHENRPGVLTALNKIFAEQGV 363 +++A ++I + +G A+N V L L G +H+ E L + + Sbjct: 303 AIQMAEQIIAWKRDGILEGAINGTIVELAQLPGAHAYLHLAEKLGATLAQCTPLDGKH-- 360 Query: 364 NIAAQYLQTSAQMGYV 379 ++TS + Y Sbjct: 361 ----ITMKTSGEFLYT 372 >UniRef50_Q5SZU1 Phosphoglycerate dehydrogenase n=11 Tax=Eutheria RepID=Q5SZU1_HUMAN Length = 499 Score = 387 bits (995), Expect = e-106, Method: Composition-based stats. Identities = 101/279 (36%), Positives = 145/279 (51%), Gaps = 7/279 (2%) Query: 51 IRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTR 110 ++D + +RS T +T DVINAAEKL +G G + VDL+AA ++GI V N P N+ Sbjct: 11 LQDCEGLIVRSATKVTADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSL 70 Query: 111 SVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILA 170 S AEL G ++ L R +P+A A G W + E GK LGI+G G IG ++ Sbjct: 71 SAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRM 130 Query: 171 ESLGMYVYFYDI--ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISL 228 +S GM YD ++ Q L ++ + D +++H P PST ++ + Sbjct: 131 QSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQ 190 Query: 229 MKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVL 288 K G ++N +RG +VD AL AL S AGAA+DVF EP P L + +NV+ Sbjct: 191 CKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEP-----PRDRALVDHENVI 245 Query: 289 LTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNF 327 PH+G ST+EAQ G E+A + + S VN Sbjct: 246 SCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNA 284 >UniRef50_D0MG73 Glyoxylate reductase n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MG73_RHOM4 Length = 322 Score = 387 bits (994), Expect = e-106, Method: Composition-based stats. Identities = 92/318 (28%), Positives = 146/318 (45%), Gaps = 14/318 (4%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGA---LDDEQLKESIRDAHFIGLRSRTHLTED 68 + ++ V ++ L L G+ LD++ L E+ R+A + +T Sbjct: 3 RIVVTRPVMEEGLRPLFENGHQVEILDPDPEHPLDEDALIEAAREADALITMPSDPVTAR 62 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 V+ KL + +G +DL+AA RGI V + P T + A+ LL L+R V Sbjct: 63 VLENCPKLRIVAQHAVGYENIDLEAARARGIVVTHTPGVLTDATADFTFALLLALVRRVR 122 Query: 129 EANAKAHRG---VWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 EA+ G W + R K LGI+G G IG+ + A GM V +Y+ Sbjct: 123 EADRYVREGHFKRWETKLLLGHDLRDKVLGIVGLGRIGSAVARRALGFGMRVVYYNRRPA 182 Query: 186 LP---LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 P + + +LL SDV+S+H P N + ++ + MKP ++L+N +RG Sbjct: 183 NPTIERQSCARYVSFDELLRTSDVISIHCPLNKESYHLFDRAAFAKMKPTAVLVNTARGP 242 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 +VD AL +AL +AGAA+DVF EP + L D V+L PH+G +T EA+ Sbjct: 243 IVDEEALVEALEQGQIAGAALDVFEHEPRVHP-----ALLRSDRVVLAPHLGSATVEART 297 Query: 303 NIGLEVAGKLIKYSDNGS 320 + A ++ + Sbjct: 298 AMARACAEAVLAVLNGEE 315 >UniRef50_C0GLG9 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Desulfovibrionales RepID=C0GLG9_9DELT Length = 394 Score = 384 bits (988), Expect = e-105, Method: Composition-based stats. Identities = 121/401 (30%), Positives = 191/401 (47%), Gaps = 14/401 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 ++ L +G+ +A+ LR G++ D E L + D + +RS T + ++I Sbjct: 1 MRILANDGLVDEAVNFLRREGFSV---DTEKRDYEDLLGDLPDFDALLVRSATKVNRELI 57 Query: 71 NAAE----KLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 AA KL IG +GT+ +DL AA + G+ V AP N + AE VIG + + R Sbjct: 58 EAATTKRGKLKIIGRGGVGTDNIDLQAAKECGVVVKFAPHGNINATAEHVIGLMFAIARK 117 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL 186 VP A+ G+W+K E +GK LG+IG G IG + A+ L M V +D++ + Sbjct: 118 VPFAHHTLKSGIWHKARFKGVELQGKTLGLIGCGRIGQAVANKAKDLDMKVIGFDMQ-RW 176 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + + ++L+ +D VS++ ++ E+ MK + LINASRG V+ Sbjct: 177 MDSEVDYMDSMEEVLDHADFVSIN---TGGAHTLIREPELERMKSSAFLINASRGVNVEE 233 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL AL + +AGAA+D + EP +PFTS L E DN++L+ H+G ST A G+ Sbjct: 234 DALYYALKNGRIAGAALDCYEKEPKREGEPFTSKLAELDNIVLSAHLGASTANAARKTGM 293 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEVSLPLH-GGRRLMHIHENRPGVLTALNKIFAEQGVNI 365 E+A + KY G +VN + + + HE++PG+ F + GVNI Sbjct: 294 EIADVVSKYLKYGDFRQSVNVGQTVIDEGIDLYTIFITHEDKPGMFGKFGTAFGDLGVNI 353 Query: 366 AAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRA 406 Q + G E + + + I G R Sbjct: 354 --QENNSRRLDGLAQTIYTIQEKPTSEMQEKLLEIDGVRRV 392 >UniRef50_D2C7W6 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Thermotoga naphthophila RKU-10 RepID=D2C7W6_THENR Length = 329 Score = 383 bits (986), Expect = e-105, Method: Composition-based stats. Identities = 114/310 (36%), Positives = 169/310 (54%), Gaps = 16/310 (5%) Query: 21 QKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIG 80 ++ ++ L G+ + K +E+L+E+I+DA + + + T +T ++I ++ L I Sbjct: 16 KEPIDYLERNGFVVLRVEK----EEELREAIKDAEALIVGTHT-VTREMIESS-NLKVIA 69 Query: 81 CFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKA-HRGVW 139 +G + +D++AA ++GIPV +N+ SVAEL I + L RG+ A+ K + W Sbjct: 70 KHGVGVDNIDVEAATEKGIPVTITLGANSLSVAELTIAFIFALSRGLIWAHNKLFYEKKW 129 Query: 140 NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE---NKLPLGNATQVQH 196 E GK +G+IG+G IG ++ A LGM V YD + + L AT V Sbjct: 130 E--GYVGQEVSGKVMGVIGFGSIGREVVKKAVCLGMNVLVYDPYVSKDSVRLLEATPVDD 187 Query: 197 LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASK 256 L LL SD VSLHVP N STKNM+G +E+SLMK + LIN SRG +VD AL AL Sbjct: 188 LEQLLKESDFVSLHVPLNESTKNMIGERELSLMKKSAFLINTSRGELVDEEALVKALKEG 247 Query: 257 HLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYS 316 +AGAA+DVF EP + SPL E N++ T HIG T+EA + + A ++ + Sbjct: 248 RIAGAALDVFSEEPPDAN----SPLFECPNLITTAHIGAHTKEAIFRMNMMAAQSIVDFF 303 Query: 317 DNGSTLSAVN 326 VN Sbjct: 304 KGRIPRYVVN 313 >UniRef50_C8WI96 D-3-phosphoglycerate dehydrogenase n=1 Tax=Eggerthella lenta DSM 2243 RepID=C8WI96_EGGLE Length = 526 Score = 383 bits (986), Expect = e-105, Method: Composition-based stats. Identities = 115/327 (35%), Positives = 167/327 (51%), Gaps = 14/327 (4%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ E + + L LR G K + E+L E++ + +RS T +T +V+ Sbjct: 4 KVLVTERLAEAGLAVLRDKGCEV--DVKLKMTPEELIETVPGYDALIVRSATKVTAEVVE 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AA++L IG +G + VD++AA + GI V NAP SN S AE IG +L R VP+AN Sbjct: 62 AADRLRIIGRAGVGVDNVDVEAATEHGIIVCNAPTSNIVSAAEHAIGLMLACARKVPQAN 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE---NKLPL 188 A H GVW + E K L I G G IG + A + GM + YD + Sbjct: 122 ASMHEGVWERGKYTGVELYEKTLAIFGLGRIGGLVAERARAFGMKLIGYDPYCSPERAEQ 181 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 T + L+ ++D +++H+P+ T M G + + MK G +L+NA+RG + D + Sbjct: 182 LGVTLYDDVDALVPLADFITVHLPKTKETIGMFGPDQYARMKDGVILVNAARGGIFDEKS 241 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L D LA+ + IDV +EP T SPL EFDN +LTPHI STQEAQ G++ Sbjct: 242 LADFLAAGKIGAVGIDVHESEPCT-----DSPLREFDNAILTPHIAASTQEAQLRAGVQT 296 Query: 309 AGKLIKYSDNGSTLSAVNF----PEVS 331 A + + +A+N PEV Sbjct: 297 AEYVAAGLEGSIVPTALNMAPVPPEVM 323 >UniRef50_C0WBM0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acidaminococcus sp. D21 RepID=C0WBM0_9FIRM Length = 529 Score = 383 bits (985), Expect = e-105, Method: Composition-based stats. Identities = 106/334 (31%), Positives = 160/334 (47%), Gaps = 9/334 (2%) Query: 9 DKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 +K K L+ E + K + L+A ++ + E L + I + + +RS T + E+ Sbjct: 2 EKQKVLVAERISDKGVVCLKAEKALDVTV-DFDIKREDLLQVIGNYDALIVRSVTKVNEE 60 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 + +AA+KL IG G + +DLD A KRGI V N P +N S AE IG LL R Sbjct: 61 LYDAAKKLKVIGRAGNGVDNIDLDGATKRGIIVVNTPEANIISAAEHTIGLLLASCRNTV 120 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE---NK 185 AN G+W + E K LGIIG G IG + + M V YD ++ Sbjct: 121 RANKMLEEGIWERKDLKGSELYHKTLGIIGLGRIGALVTKRMHAFDMRVIAYDPYIPDSR 180 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 + + L DLL +DV+++H P+ T NM+GA E K G ++N +RG + + Sbjct: 181 FQRLGVEKCETLDDLLKEADVITIHTPKTEETVNMLGAAEWKKCKKGVRVVNCARGGLYN 240 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 L +A+ +A +DV EP SPL ++TPH+G ST EAQ+ +G Sbjct: 241 EQDLAEAVKEGIVASVGLDVVVDEPNP-----ISPLIGMPQCVVTPHLGASTFEAQDKVG 295 Query: 306 LEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRR 339 L +A ++I +AVN P ++ R Sbjct: 296 LAIAEEVINVLGGKMVPNAVNLPAIAATELEDLR 329 >UniRef50_B1KZ88 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=29 Tax=Clostridiaceae RepID=B1KZ88_CLOBM Length = 314 Score = 383 bits (984), Expect = e-105, Method: Composition-based stats. Identities = 108/311 (34%), Positives = 169/311 (54%), Gaps = 10/311 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 IK L+ +G+ + AL L G+ ++ H + E+LK+ I+D I +RS T + +++I Sbjct: 2 IKILVSDGMEKNALNKLNEQGFVVLDKH---FEKEELKDKIKDFDAIIIRSATKVDKEII 58 Query: 71 NAA--EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 +A L + +G + VDL+ A ++G+ VFN P +++ SVAEL +G +L + R + Sbjct: 59 DAGIKGNLKLVVRAGVGLDNVDLEYAKEKGVKVFNTPKASSVSVAELTLGHMLCISRFIN 118 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL 188 AN +G W K E GK LG+IG+G I ++ A +LGM V +YDI K Sbjct: 119 TANVTMLQGKWEKKKYKGTEIYGKTLGLIGFGRIAREVAKRANALGMNVIYYDIAGKCEE 178 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + L LLN SD +S+H+P N ++ +E + MK G ++N +RG V++ A Sbjct: 179 YEEFKCCTLDYLLNNSDFISVHIPFNKDRGALLKEEEFNKMKDGVYIVNCARGGVIEEEA 238 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L AL + + AA+DVF EP + L + V +TPHIG ST+EAQ IG E+ Sbjct: 239 LLKALNNGKVTAAALDVFENEPEPKKE-----LINHERVSITPHIGASTKEAQMRIGEEI 293 Query: 309 AGKLIKYSDNG 319 L + + G Sbjct: 294 VDILDNFFNVG 304 >UniRef50_A7GQE1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Firmicutes RepID=A7GQE1_BACCN Length = 390 Score = 382 bits (983), Expect = e-104, Method: Composition-based stats. Identities = 113/415 (27%), Positives = 188/415 (45%), Gaps = 43/415 (10%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + + +K L+ A Y + + I I LRS + E++ Sbjct: 2 FHIQTLNQIAEKGLQVFAAERYN-------------IGQRIEHPDGILLRSYSLHQEEL- 47 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 ++ L AI G N + +D ++GI VFN P +N +V EL++ +L R + Sbjct: 48 --SKNLKAIARAGAGVNNIPIDRCTEKGIVVFNTPGANANAVKELILASFILSSRNIING 105 Query: 131 NAKAH--RGVW-------NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD 181 + G K E GK+LG+IG G IG + A SLGM V YD Sbjct: 106 VSWTKGLEGKEIPQLVEAGKKQFVGSEIAGKRLGVIGLGAIGALVANDALSLGMDVVGYD 165 Query: 182 IENKLPLG-----NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLI 236 + + + L ++ D ++LH+P T+ ++G + +MK G L Sbjct: 166 PYISVETAWRLSTHVQRAFSLDEIFATCDYITLHIPLTEQTRGIIGEHAVRMMKKGVRLF 225 Query: 237 NASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGS 296 N SRG +VD AL AL + + D FP E + + NV+ TPH+G S Sbjct: 226 NFSRGELVDETALEKALEEETINHYMTD-FPNE----------NVIKMKNVVATPHLGAS 274 Query: 297 TQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNK 356 T E++EN + A +L Y + G+ ++VN+P V LP G +R+ +H+N P ++ + Sbjct: 275 TYESEENCAVMAACQLRDYLETGNIRNSVNYPNVELPYVGKKRITIMHQNVPNMVGQITG 334 Query: 357 IFAEQGVNIAAQYLQTSAQMGYVVIDIE--ADEDVAEKALQAMKAIPGTIRARLL 409 AE +NIA ++ Y +IDI+ D+ + E ++ ++ I G + R++ Sbjct: 335 CLAEHHINIADMINRSKNSWAYTMIDIDNGMDDRMKENIVENIRRITGVVAVRMI 389 >UniRef50_B9L1V2 Glyoxylate reductase n=2 Tax=Thermomicrobia (class) RepID=B9L1V2_THERP Length = 333 Score = 382 bits (982), Expect = e-104, Method: Composition-based stats. Identities = 107/309 (34%), Positives = 153/309 (49%), Gaps = 11/309 (3%) Query: 21 QKALESLRAAGYTNIEFH-KGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAI 79 ++ L G +E + +D+EQL E +RD + + +T V+ A +L I Sbjct: 26 EEIARFLEERGCRFVEKEIRYPVDEEQLCELVRDVDGLVV-GLEPITARVLAHANRLKVI 84 Query: 80 GCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVW 139 +G + +D+ A +RGI V N +N SVAEL G +L L RG+ ++ G W Sbjct: 85 STSGVGFDNIDVAEATRRGIVVANCHGANEHSVAELAFGLMLALARGIHRSDRLMREGRW 144 Query: 140 NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQ--VQHL 197 E GK LG+IG G G + +L GM V +DI NA + L Sbjct: 145 E--PYFGVELWGKTLGVIGLGRAGRAVALLGRGFGMRVLAHDIVWDTTFANAHEISYVPL 202 Query: 198 SDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKH 257 LL SD VSLHVP P T+ ++ + +SLMKP + LIN +RG VV AL +AL Sbjct: 203 EKLLRESDFVSLHVPLTPDTRYLIDERALSLMKPTAFLINLARGPVVKQSALVEALRRGQ 262 Query: 258 LAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSD 317 +AGA +DVF EP +P EF+NV++TPH+GGST+EA+E + + Sbjct: 263 IAGAGLDVFEVEPIR-----DNPFVEFENVVMTPHLGGSTEEARERTLYLALTNVCNVLN 317 Query: 318 NGSTLSAVN 326 VN Sbjct: 318 GRPPHHQVN 326 >UniRef50_B7CA05 Putative uncharacterized protein n=1 Tax=Eubacterium biforme DSM 3989 RepID=B7CA05_9FIRM Length = 382 Score = 381 bits (980), Expect = e-104, Method: Composition-based stats. Identities = 113/411 (27%), Positives = 178/411 (43%), Gaps = 50/411 (12%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K L + Q L+ D ++ E++ D I +RS I Sbjct: 2 PKIKLYNNIAQIGLDQF--------------TPDYEVNENMEDEDAILVRSANLHD---I 44 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 L AI G N +D+D K+GI VFN P +N+ +V E V +LL R + Sbjct: 45 EYGNNLKAIARAGAGVNNIDIDTCTKKGIAVFNTPGANSNAVKEFVFAGMLLASRDIYHG 104 Query: 131 NAKAHRGVWN----------KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 N K E GK LG+IG G IG Q+ LA GM VY Y Sbjct: 105 IEWIQTQKENENIAKDVEKQKKKYAGHELTGKSLGVIGCGAIGIQVANLALRFGMKVYGY 164 Query: 181 DIENKLPLG-----NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLL 235 D + V ++ DL D +++HVP N TKN + MK G L Sbjct: 165 DPYMSVDAAWNLSRYVNHVTNIDDLYRQCDFITIHVPLNDGTKNFINKDSFDKMKDGVKL 224 Query: 236 INASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGG 295 +N +RG +VD AL +AL +A D FP + + + D V+ PH+G Sbjct: 225 LNFARGGLVDEDALLEALDENKVASYVTD-FP----------SQKVLQSDKVIAIPHLGA 273 Query: 296 STQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALN 355 ST+E++EN ++ A +L+ Y G+ ++VN P + ++ R+ IH+N+P +++ + Sbjct: 274 STEESEENCAVKAARELMDYLTYGNISNSVNLPNAKMDMNSPFRITCIHDNKPKMISQIT 333 Query: 356 KIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRA 406 I + NI ++ + Y +ID++ D+ ++ I G I+ Sbjct: 334 DILKD--ANIENLMNKSKKDIAYTIIDLDTKVDITP-----IEKINGMIKV 377 >UniRef50_Q2RH37 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=6 Tax=Bacteria RepID=Q2RH37_MOOTA Length = 329 Score = 381 bits (979), Expect = e-104, Method: Composition-based stats. Identities = 110/333 (33%), Positives = 148/333 (44%), Gaps = 11/333 (3%) Query: 9 DKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 K + V Q AL+ L I L +L E +R I L ++ Sbjct: 2 SKWNVYVTRLVPQPALDLLAEYCDLEINPEDRVLTRAELLEKVRGRDGILCLLTDILDDE 61 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 V AA+ +G N VDL+AA + GI + N P T + A++ L + R V Sbjct: 62 VFTAAKGAKIFANLAVGFNNVDLEAATRHGIMITNTPGVLTEATADMAWALLFAVARRVV 121 Query: 129 EANAKAHRGV---WNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 E + G W L E GK LG+IG G IGT A M V ++D++ Sbjct: 122 EGDKFTRAGKYKGWGPLLMLGQEITGKTLGVIGAGRIGTAFARKARGFDMKVLYHDVQPS 181 Query: 186 LPLGNAT--QVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 AT Q LL +D VSLHVP PST +++ E+ LMK ++LIN SRG V Sbjct: 182 KAFEEATGGQFVDKETLLKEADFVSLHVPLMPSTTHLISTPELKLMKKTAILINTSRGPV 241 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 VD AL AL K + GA +DVF EP L + +NV+L PHI +T E + N Sbjct: 242 VDEKALVKALREKEIWGAGLDVFENEPELAPG-----LADLENVVLCPHIASATWETRTN 296 Query: 304 IGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHG 336 + L A L+ +N PEV HG Sbjct: 297 MALMAANNLLAALRGELPPQCLN-PEVYYRQHG 328 >UniRef50_A6CKS4 Putative uncharacterized protein n=2 Tax=Bacillaceae RepID=A6CKS4_9BACI Length = 322 Score = 381 bits (979), Expect = e-104, Method: Composition-based stats. Identities = 103/327 (31%), Positives = 168/327 (51%), Gaps = 11/327 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K L+ + + ++ ++ L G I ++E L + D I +R+ L+ VI Sbjct: 3 FKVLIPQPIAKEGIDLLEKEGAEVI--IPPDYNEETLISHVSDVDAILIRTA-KLSRVVI 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A KL I IG + +DL+AA+ RGI V NAPF+N +VAE V+ +L R + + Sbjct: 60 EKASKLKVIARHGIGVDNIDLEAASDRGILVTNAPFANVNAVAEHVLTLILSGSRQLIQV 119 Query: 131 NAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIENKLP- 187 ++ G + + E +GK LG++G+G+IG + LGM V YD + Sbjct: 120 DSALRNGDFEVRNRKFGIELKGKTLGVVGFGNIGQLVAEKCHYGLGMDVLVYDPYVREEN 179 Query: 188 LGNATQV-QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + + Q+ Q LS++L SD+V++HVP PST +++ + + MK ++L+NA+RG ++D Sbjct: 180 VSSYVQLNQSLSEVLASSDIVTIHVPYLPSTHHLINEEALQQMKKDAILVNAARGGIIDE 239 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL AL S + GA +D F TEP L +NV++TPH+ T+EA + + Sbjct: 240 IALEKALGSGEIRGACLDCFETEPPAVD----HSLWNLENVIVTPHLAAHTEEAMIEMAV 295 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEVSLP 333 A +I L VN E+ + Sbjct: 296 TPAKDIIAIMKGEKPLYPVNEKEIKVS 322 >UniRef50_A7SFV8 Predicted protein (Fragment) n=1 Tax=Nematostella vectensis RepID=A7SFV8_NEMVE Length = 487 Score = 380 bits (978), Expect = e-104, Method: Composition-based stats. Identities = 99/319 (31%), Positives = 155/319 (48%), Gaps = 7/319 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ + V L G ++ + L E+L I + +RS T ++EDVI Sbjct: 8 RVLISDSVDSCCKTILERNG-VTVDVNT-KLSKEELVSEIPKYDGLIVRSATKVSEDVIK 65 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A + L IG G + +D AA+ G+ V N P NT S AE + L R +P+A+ Sbjct: 66 AGKNLKIIGRAGTGVDNIDTVAASLHGVLVMNTPGGNTLSAAEHTCALISSLARHIPQAS 125 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--ENKLPLG 189 A G W + E GK L IIG G IG ++ + +S G+ YD + Sbjct: 126 ASTKEGKWERKQFMGNELFGKTLAIIGLGRIGREVALRMQSYGVKTIGYDPLVSPQDAAE 185 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 + + + ++D +++HVP P TK M+ K I + K G ++N +RG ++D AL Sbjct: 186 SNIEWMETEKIWPLADYITVHVPLIPPTKGMLNDKTIGMCKKGVYILNVARGGIIDEEAL 245 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 L S H+ GA +DVF TEP T S ++ L + V+ PH+G ST+EAQ + E+A Sbjct: 246 LRGLESGHVGGAGLDVFVTEPPTGS---SADLVKHPKVIACPHLGASTEEAQRRVAQEIA 302 Query: 310 GKLIKYSDNGSTLSAVNFP 328 + + + + VN P Sbjct: 303 DQFVDGMNGKPLIGLVNVP 321 >UniRef50_Q18DJ4 Phosphoglycerate dehydrogenase n=13 Tax=Halobacteriaceae RepID=Q18DJ4_HALWD Length = 534 Score = 380 bits (978), Expect = e-104, Method: Composition-based stats. Identities = 124/395 (31%), Positives = 189/395 (47%), Gaps = 28/395 (7%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 ++ L+ + + LE LRAAG+ + + DE L +I D + + +RS T + E V Sbjct: 3 MQVLVTDPIDDAGLERLRAAGHGVETAYD--IGDEALLNTITDVNALVVRSGTDVNEAVF 60 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA L+ +G IG + +D+DAA + G+ V NAP N R+ AE + R +P+A Sbjct: 61 EAASDLIIVGRAGIGVDNIDIDAATEHGVIVANAPEGNVRAAAEHTVAMTFAGARSIPQA 120 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 +A+ G W K E GK LG++G G +G ++ ESLGM + YD Sbjct: 121 HARLRTGEWAKSEYLGTEVNGKTLGVVGLGRVGQEVAKRLESLGMDLVAYDPYISEDRAE 180 Query: 191 --ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 ++ L ++ +++H P T M+ E+ LM G LIN +RG VVD A Sbjct: 181 RLGAELVEFDTCLERAEFLTVHTPLTSETAGMISTTELELM-DGGYLINCARGGVVDEDA 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L A+ L GAA+DVF EP S L DN+++TPH+G ST+ AQEN+ + Sbjct: 240 LAAAVEDGVLDGAAVDVFADEPVAPD----SALLSVDNIVVTPHLGASTEAAQENVATSI 295 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 A ++ ++A+N P V + P + ++ AE IAAQ Sbjct: 296 ADQIDAAFAGAPVMNALNAPSVDESVF------------PRIRPYID--LAETAGKIAAQ 341 Query: 369 YLQTSAQMGYVVIDIE---ADEDVAEKALQAMKAI 400 L ++ V + E ADEDV A+K + Sbjct: 342 LLD--GRISSVSVSYEGDIADEDVELATASALKGV 374 Score = 44.2 bits (104), Expect = 0.009, Method: Composition-based stats. Identities = 16/78 (20%), Positives = 33/78 (42%), Gaps = 1/78 (1%) Query: 333 PLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSA-QMGYVVIDIEADEDVAE 391 + G+ L+ + ++PGV+ + + E +NIA + + G + D+ V Sbjct: 448 AVPHGKMLVARNADKPGVIGFIGSVLGEHNINIAGMFNARRDIEGGEALTIYNLDDSVPT 507 Query: 392 KALQAMKAIPGTIRARLL 409 ++ + A I R L Sbjct: 508 DVVERLLADERMIDVRYL 525 >UniRef50_UPI00016C495D phosphoglycerate dehydrogenase n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C495D Length = 539 Score = 380 bits (976), Expect = e-104, Method: Composition-based stats. Identities = 113/343 (32%), Positives = 180/343 (52%), Gaps = 9/343 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ + + +E L+AAG ++ L ++LK +I+ A + RS+ L+ + + Sbjct: 3 RVLIADKLESSGIELLQAAGIEV--DNRPGLKGDELKAAIQAADAVICRSQPKLSAEYFD 60 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 K+ A+ +G + +D+ AA ++G+ V N P NT S AE I LL L R +P A+ Sbjct: 61 NPGKMRAVARAGVGVDNIDVAAATRKGVVVMNTPGGNTVSAAEHTIALLLALSRRIPAAD 120 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD---IENKLPL 188 A G W++ E GK LG++G G IG ++ A+ L M V D K+ Sbjct: 121 ATMKAGGWDRNKFVGTEVAGKVLGVVGLGRIGREVARRAKGLDMKVIALDQFVTAAKVAE 180 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 L +LL D ++LHVP TK+M+GA+E+ LMK + ++N +RG ++D A Sbjct: 181 LGYESAASLDELLPKVDYLTLHVPGGAETKSMVGARELGLMKKTARVLNVARGGIIDEKA 240 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +ALA+ +AGA +DVF EP + PL + N+++TPH+G ST EAQEN+ +E Sbjct: 241 LAEALAAGTIAGAGVDVFSVEPIAADN----PLAKAPNIVITPHLGASTLEAQENVAVEA 296 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVL 351 A + + +G +AVN V+ R R G+L Sbjct: 297 AQLIKDFLLSGQVANAVNMAAVNPAELAEVRPYVDLARRLGLL 339 >UniRef50_Q4WHR3 D-3-phosphoglycerate dehydrogenase n=3 Tax=Eurotiomycetidae RepID=Q4WHR3_ASPFU Length = 635 Score = 379 bits (974), Expect = e-103, Method: Composition-based stats. Identities = 112/381 (29%), Positives = 180/381 (47%), Gaps = 58/381 (15%) Query: 4 VSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRT 63 +S ++ K L+ E + L LRA+ + + LD ++L + I + + +RS T Sbjct: 2 LSAKQPPPKVLVPEKLSPDGLALLRASLEVD---ERRGLDADELLQIIPEYEALVVRSET 58 Query: 64 HLTEDVINAAEKLVAIGCFCIGTNQV------------------------DLDAAAKRGI 99 +T +++ AA++L + +G + V D++ A K GI Sbjct: 59 KVTANLLRAAKQLKVVARAGVGVDNVGELAQPPLPPSPSLGSWPLTSHRTDVEEATKLGI 118 Query: 100 PVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGY 159 V N+P N + AE I L+ + R +PEA + G W + E +GK L IIG Sbjct: 119 VVVNSPSGNIGAAAEHTIALLMAMARNIPEACSSLKSGKWERSKFVGVEVKGKTLSIIGL 178 Query: 160 GH---------------------------IGTQLGILAESLGMYVYFYDIENKLPLGNA- 191 G +G + LA+ LGM+V D + + Sbjct: 179 GKGELLAIWGRGIHFRYDGGSSGWADRQTVGLTVARLAKGLGMHVNALDPYASPAVAASA 238 Query: 192 --TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 T V LS+LL +D +++H P STK M+ E++ MKPG+ ++N +RG +D AL Sbjct: 239 SVTLVSSLSELLPTADFLTIHTPLIASTKGMISTAELAQMKPGARILNVARGGTIDEAAL 298 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 ++L S HLA AAIDVF TEP + + L ++TPH+G ST EAQEN+ ++V Sbjct: 299 LESLESGHLAAAAIDVFTTEPPQP-ESTAARLVAHPRAVVTPHLGASTVEAQENVSIDVC 357 Query: 310 GKLIKYSDNGSTLSAVNFPEV 330 ++++ + SAVN P + Sbjct: 358 EQVLQILNGSLPRSAVNAPLI 378 >UniRef50_A5IK90 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=6 Tax=Thermotogaceae RepID=A5IK90_THEP1 Length = 327 Score = 378 bits (973), Expect = e-103, Method: Composition-based stats. Identities = 116/323 (35%), Positives = 164/323 (50%), Gaps = 22/323 (6%) Query: 12 KFLLVE----GVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 K L+V Q+ +E L+ G+ I +D + LKE + + + +T Sbjct: 3 KVLIVTRTFGKYSQEPVEFLKKEGFEII--RSDTIDPDILKE----VDALIVGTH-PVTA 55 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 ++I + L I +G + +DL+AA K+GIPV +N+ SVAEL I + L+RG+ Sbjct: 56 EMIENS-SLKVIAKHGVGVDNIDLEAATKKGIPVTITAGANSLSVAELTIAFIFALIRGL 114 Query: 128 PEANAKA-HRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL 186 A+ K W E GK LG++G+G IG ++ A LGM V YD Sbjct: 115 VWAHNKLFLERKWE--GTVGQEVSGKTLGVVGFGSIGREVVKKAVCLGMNVLVYDPYVSK 172 Query: 187 P---LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 L AT V L LL SD VSLHVP N STKNM+G +E+SLMK + LIN SRG + Sbjct: 173 DNVRLLEATPVDDLDQLLKESDFVSLHVPLNESTKNMIGERELSLMKKSAFLINTSRGGL 232 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 VD AL AL +AGAA+DVF EP + SPL + N++ T HIG T+E+ Sbjct: 233 VDEEALVKALKEGRIAGAALDVFSEEPPNPN----SPLFKCPNLITTAHIGAHTKESILR 288 Query: 304 IGLEVAGKLIKYSDNGSTLSAVN 326 + + A ++ + VN Sbjct: 289 MNMMAAQSVVDFFKGNIPKYVVN 311 >UniRef50_B3T9W6 Putative D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein n=1 Tax=uncultured marine microorganism HF4000_APKG7H23 RepID=B3T9W6_9ZZZZ Length = 491 Score = 378 bits (971), Expect = e-103, Method: Composition-based stats. Identities = 100/291 (34%), Positives = 156/291 (53%), Gaps = 7/291 (2%) Query: 49 ESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSN 108 E I + +RS T +T +I A L IG +G + VDLDAA ++GIPV NAP N Sbjct: 3 EIIGGYEALIVRSETQVTAGLIEAGGHLQVIGRAGVGVDNVDLDAATRQGIPVVNAPTGN 62 Query: 109 TRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGI 168 T + AE + +L ++R +P+A+A G W + A E RGK LGIIG G +G+++ Sbjct: 63 TVAAAEHTLALMLAMVRHIPQADASVRMGEWRRSAFMGVEVRGKILGIIGLGKVGSEVAR 122 Query: 169 LAESLGMYVYFYDI--ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEI 226 +L M + +D + ++ L L+ +D +++H P +T+ ++G + Sbjct: 123 RTRALQMRILAHDPFVPQESARSLGVEMVSLDQLMAEADFITIHTPLTATTQQLLGPAQF 182 Query: 227 SLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDN 286 +K G +INA+RG +V+ L +AL S +AGAA+DVF EP SPL + Sbjct: 183 QQLKHGVRIINAARGGLVNEQLLLEALESGRVAGAALDVFVEEPPKQ-----SPLLQHPR 237 Query: 287 VLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGG 337 V+LTPH+G ST+EAQ + LE+A +++ S VN P + + Sbjct: 238 VVLTPHLGASTEEAQTEVALEIADQVLAVLAGSSAQYTVNVPYIPEEVREA 288 Score = 48.1 bits (114), Expect = 6e-04, Method: Composition-based stats. Identities = 25/87 (28%), Positives = 43/87 (49%), Gaps = 4/87 (4%) Query: 325 VNFPEVSLPLHGGRRLMHI--HENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVID 382 VN + SL L R M H +RPG++ + I E +NI+ + A G + Sbjct: 405 VN--DFSLDLQPTGRFMMFTEHTDRPGMIGRMGTIAGEHDINISFMEVGRRAPRGEATMI 462 Query: 383 IEADEDVAEKALQAMKAIPGTIRARLL 409 + D+ ++++AL +AIP R R++ Sbjct: 463 VGLDDPISDEALAEFRAIPHVSRVRVV 489 >UniRef50_C2HP35 Glyoxylate reductase n=10 Tax=Lactobacillus RepID=C2HP35_LACAC Length = 330 Score = 377 bits (968), Expect = e-103, Method: Composition-based stats. Identities = 95/326 (29%), Positives = 168/326 (51%), Gaps = 14/326 (4%) Query: 9 DKIKFLLVEGVHQKALESLRAAGYTNIEF--HKGALDDEQLKESIRDAHFIGLRSRTHLT 66 +K K L++ G+ AL+ LR+ + H+ D + + ++I + + ++ Sbjct: 11 NKAKVLVLGGLIDDALDDLRSTCEVTVGPVGHRPNDDRQWVLKNIAKYDGVIV-AKMIFD 69 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 +++I+AA+ L I + +G + +D+D A ++GI V N P S R AEL + ++ R Sbjct: 70 KEIIDAAKNLKVISTYGVGFDHIDIDYAREKGIVVTNCPNSVLRPTAELALTMIMASARR 129 Query: 127 VPEANAKAHRGVW---NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE 183 + + GV+ ++ + + GK LGI+G G IG Q+ A++LGM + +++ Sbjct: 130 IRYYDHALREGVFLNVDEYDSQGYTIEGKTLGILGMGRIGQQVARFAKALGMKIIYHNRH 189 Query: 184 ---NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 +L + + L+ SD +SLH P T +++ + MK S LIN +R Sbjct: 190 QLKPELEAELNARYVDFASLVKNSDFLSLHAPATDETYHIIDKDVFNNMKDTSFLINVAR 249 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G++VD L AL +AGAA+DVF EP D L DNV++TPH+G +T +A Sbjct: 250 GSLVDSDDLVAALKEGKIAGAALDVFENEPYPKQD-----LVNMDNVIMTPHVGSATHKA 304 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVN 326 + N+ E A ++ + G +++VN Sbjct: 305 RYNLTKEAANNILTFFKEGKVINSVN 330 >UniRef50_A1HQU2 Glyoxylate reductase n=1 Tax=Thermosinus carboxydivorans Nor1 RepID=A1HQU2_9FIRM Length = 324 Score = 375 bits (964), Expect = e-102, Method: Composition-based stats. Identities = 91/321 (28%), Positives = 146/321 (45%), Gaps = 7/321 (2%) Query: 9 DKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 K + ++ + AL + + + + L E + DA + + ++ Sbjct: 2 KKYQVVVAGKMRPCALAKISSECHVRQWDKIEPIPRNLLYEWLADAEGLVSTGDVRVDDE 61 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 ++ A +L I +G + VD+ A +RGIP N P + A+L G LL R + Sbjct: 62 LLAHAPRLRVIAQASVGYDNVDIAACTRRGIPFGNTPGVLVEATADLTFGLLLCAARRIH 121 Query: 129 EANAKAHRGVW--NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL 186 E + G W N + GK LGI+G G IG + A++ GM V +++ + Sbjct: 122 EGWNQVASGRWLNNHDVPFGIDLYGKTLGIVGMGRIGAAVARRAKACGMKVIYHNRSRRT 181 Query: 187 PLGN-ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 + DLL +D + + VP +P+++ M G E + MK + INA+RG +VD Sbjct: 182 DDEHLGATYVAFDDLLAQADCIVVLVPLSPASQGMFGRAEFAKMKRTAYFINAARGGLVD 241 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL DAL +A AA+DV EP P PL NVL+TPHIG +T E ++ + Sbjct: 242 TQALYDALKEGQIAYAALDVTDPEPL----PGDHPLLTLPNVLITPHIGSATHETRDRMA 297 Query: 306 LEVAGKLIKYSDNGSTLSAVN 326 + A L+ + VN Sbjct: 298 MLTADNLLAGLARRPLPACVN 318 >UniRef50_D0MDQ9 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MDQ9_RHOM4 Length = 406 Score = 373 bits (958), Expect = e-102, Method: Composition-based stats. Identities = 124/405 (30%), Positives = 188/405 (46%), Gaps = 13/405 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIR--DAHFIGLRSRTHLTED 68 ++ LL + + + LE+LR G T ++ L + L E++ + + +RS T +T + Sbjct: 1 MQVLLADKLEDRCLEALRGLGLTV--HNRPELKEAALSEALSALNPEILVVRS-TRVTAE 57 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 ++ AA L I G + +D+ AA+ RGI V N P N +VAEL G +L L R +P Sbjct: 58 MMAAAPALELIIRAGAGYDTIDVGAASDRGIFVANCPGKNAVAVAELTFGLILALDRFIP 117 Query: 129 EANAKAHRGVWNKLAAG-SFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP 187 E A G WNK A +G+ LG+IG GHIG ++ A + M V + Sbjct: 118 ENVLDAREGRWNKAAYSKGRGLKGRTLGVIGLGHIGREVVRRAHAFEMPVVAWSRSLTDE 177 Query: 188 LGNATQVQHLS---DLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 L V + ++ +D+V++H+ P T+++ MKPG+ IN SR ++V Sbjct: 178 LARELGVVRKNSPLEVAAEADIVTIHLAAAPETRHLANRAFFEAMKPGAYFINTSRSSLV 237 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL AL + + AA+DV EPA S F PL V T HIG ST++AQE I Sbjct: 238 DEEALAWALEHRGIR-AALDVMEGEPAAKSGSFAHPLAGHPQVYFTHHIGASTKQAQEAI 296 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVN 364 EV + Y + G + VN E S H L H ++ GVL ++ N Sbjct: 297 ADEVVRIIKTYLETGHAPNCVNLEEHSPATHL---LTVRHLDKVGVLASVLDEVRRANWN 353 Query: 365 IAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 + A I D E +Q + A+P + L+ Sbjct: 354 VQEMENLIFAGARAACARIRFDGRPDEAVVQRIAALPDVLAVSLI 398 >UniRef50_C2D1B3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Lactobacillus RepID=C2D1B3_LACBR Length = 327 Score = 372 bits (956), Expect = e-101, Method: Composition-based stats. Identities = 110/319 (34%), Positives = 173/319 (54%), Gaps = 10/319 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K ++ + + + + L G IE D L E RDA + + H+ E V++ Sbjct: 17 KVVVPKSLSEDGKKFLTDRGIDIIEVDGNFTDG--LLEHGRDADGMIIF-LDHVGEAVLS 73 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 L I +G + +DLDA+A+ G+ V N P +N +VAE + E+ L + V +A+ Sbjct: 74 QMPNLKIIARHGVGYDSIDLDASAQHGVWVTNTPNANAATVAETTLAEIFDLSKNVTKAS 133 Query: 132 AKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 ++ +G + LA F+ GK LGIIGYGHIG Q+ A +L M + Y+ K Sbjct: 134 SEMRKGNYTYALAHRGFDLAGKTLGIIGYGHIGQQVAKKASALDMPILIYNRSKKESPYG 193 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 + L LL +D+V+LH+ NP+T +++G +++ MK S+LIN RG ++D AL Sbjct: 194 --KFVDLDTLLKTADIVTLHLASNPATHHIIGKDQLAEMKRSSVLINLGRGGLIDTSALI 251 Query: 251 DALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAG 310 +AL + +AGAA+DVF EP P S L +FDNVLLTPHIG ST E+ + ++ A Sbjct: 252 NALKTHQIAGAALDVFEEEPL----PLDSDLFQFDNVLLTPHIGSSTVESFSRMAVDAAS 307 Query: 311 KLIKYSDNGSTLSAVNFPE 329 ++++ + VN P+ Sbjct: 308 EVVRVLNGEKPQWPVNEPK 326 >UniRef50_B0TB58 Glyoxylate reductase n=7 Tax=cellular organisms RepID=B0TB58_HELMI Length = 328 Score = 372 bits (956), Expect = e-101, Method: Composition-based stats. Identities = 97/322 (30%), Positives = 154/322 (47%), Gaps = 9/322 (2%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 + K L+ + Q AL+ ++ ++ + +L+ + DA + + +DV Sbjct: 6 RPKVLVTREIPQPALDRIKEFARLDLWPAFPPPEKGELQRMLADADALLCMITDPIDDDV 65 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I A +KL I + +G + +D+ AA +R I V N P + T + A+L LL R + Sbjct: 66 IEAGKKLRVIANYGVGYDNIDIAAATRRRIAVTNTPDALTEATADLAFALLLATARNLIA 125 Query: 130 ANAKAHRGVWNKLAAG---SFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--N 184 A+ G W + G LGI+G G IG + A M+V + Sbjct: 126 ADRFTRDGFWIAWHPQLLLGRDVFGSTLGIVGLGRIGEAVARRARGFNMHVLYTARRRNP 185 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 K + L +LL SD VSLH P T++++GAKE+++MKP ++LIN +RG VV Sbjct: 186 KAEAELGIEYCTLEELLRRSDFVSLHTPLTLETRHLIGAKELNMMKPTAILINTARGGVV 245 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL +AL + GA +DVF EP + L E NV+++PHIG +T EA+ + Sbjct: 246 DQEALTEALQQGVIGGAGLDVFAEEPVAPEE----ALLELPNVVVSPHIGSATVEARTRM 301 Query: 305 GLEVAGKLIKYSDNGSTLSAVN 326 GL + + + VN Sbjct: 302 GLMAVENIQAVLEGRRPPNLVN 323 >UniRef50_D1YY17 Glycerate dehydrogenase n=1 Tax=Methanocella paludicola SANAE RepID=D1YY17_METPS Length = 326 Score = 371 bits (953), Expect = e-101, Method: Composition-based stats. Identities = 107/321 (33%), Positives = 157/321 (48%), Gaps = 13/321 (4%) Query: 11 IKFLLVEGVH--QKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 +K ++ E ++ + L A G + DE I+DA I + R + + Sbjct: 1 MKIVISEPIYLTDEYRRRLEALGDLR-AYDSVPTSDEDFVSRIKDAE-IVIAGRYGFSGE 58 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 I A L I + G + VDL AA RG+ V N +VAE L LLR V Sbjct: 59 SIRRAPGLKMIALWQTGYDNVDLAAATARGVVVSNVHNYAFDTVAEFAFALALNLLRKVD 118 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVY---FYDIENK 185 +A+ RG+++ E GK LG+IG G IG ++ +A M V + + + Sbjct: 119 KADLNLRRGLFDWRRYVGEELMGKTLGVIGLGSIGRRVVQIAHGFNMSVLSVTAH-PDPE 177 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 + L LL SDVVSLHVP P T++M+GA +++ MKP ++LIN +RG +VD Sbjct: 178 RARALGVKFVSLDTLLAESDVVSLHVPLTPETEHMIGAAQLARMKPTAILINTARGKIVD 237 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL +AL K +AGA +DVF TEP P SPL + DNV+LTPHI ++E+ + Sbjct: 238 EKALVEALREKRIAGAGLDVFETEPL----PMDSPLLKLDNVVLTPHIAFLSKESIDECT 293 Query: 306 LEVAGKLIKYSDNGSTLSAVN 326 + + G + VN Sbjct: 294 RVTMENVEMFVK-GRPQNVVN 313 >UniRef50_Q1J0H2 D-3-phosphoglycerate dehydrogenase n=8 Tax=Deinococci RepID=Q1J0H2_DEIGD Length = 542 Score = 370 bits (951), Expect = e-101, Method: Composition-based stats. Identities = 108/326 (33%), Positives = 172/326 (52%), Gaps = 14/326 (4%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 ++ L+ + ++ L G+ ++G L E+ + + RSRT + ++ Sbjct: 16 PLRVLICDEMNPG---DLHHEGFEI--DYEGNLPREETLRRLPGYDALITRSRTKVDREL 70 Query: 70 INAA-EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 + AA ++L IG +G + +DL+A ++RGI V NAP SN S AEL I LL RG+ Sbjct: 71 LEAAGDRLKVIGRGGVGVDNIDLEACSRRGILVLNAPESNNVSAAELAIMHLLAAARGLT 130 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI---ENK 185 ++ K G W++ E + K LGI+G G IG+ + A+ L + V YD ENK Sbjct: 131 RSDRKTRAGEWDRK-FLGVELKDKTLGIVGLGRIGSIVADRAQGLRLKVVAYDPYVPENK 189 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 + L +LL D +++H P T M+GA+E++L+K G++++NA+RG +V Sbjct: 190 FERLGVERAATLDELLTRVDFLTVHTPLTEETNGMIGARELALLKRGAIVVNAARGGIVQ 249 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL +AL S HL A +DVF EP PF S N+ +T H+G +T EAQE +G Sbjct: 250 EAALVEALQSGHLFAAGVDVFVEEPPAPDHPFLSA----PNLGITAHLGANTFEAQERVG 305 Query: 306 LEVAGKLIKYSDNGSTLSAVNFPEVS 331 E+ G+++ + AVN P + Sbjct: 306 AEIVGRVLAALHGDVSKGAVNAPALD 331 >UniRef50_C4DLZ3 Lactate dehydrogenase-like oxidoreductase n=1 Tax=Stackebrandtia nassauensis DSM 44728 RepID=C4DLZ3_9ACTO Length = 324 Score = 370 bits (950), Expect = e-101, Method: Composition-based stats. Identities = 103/322 (31%), Positives = 152/322 (47%), Gaps = 14/322 (4%) Query: 12 KFLLVEGVHQKALE---SLRAAGYTNIE--FHKGALDDEQLKESIRDAHFIGLRSRTHLT 66 + L+ E L AG + F+ L + I + + Sbjct: 5 RVLVTTAWLSPGDEVHRLLTDAGCDVVHSSFNDRDSSPATLAALVTGFDGI-VAGTDRFS 63 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 +VI AA++L G +G + +D+ AA +RGI V P N +SVAE LL + RG Sbjct: 64 AEVIAAADRLKVFGRTGVGYDNIDVAAATERGIAVCPTPGVNRQSVAEHTFALLLSVARG 123 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL 186 VP G W +++ E G LG+IG G IG + +A GM V +D Sbjct: 124 VPGNVTAVAAGDWPQVS--GRELSGATLGLIGLGAIGKAVARIALGFGMRVIAHDPYLDA 181 Query: 187 PL--GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + + L +LL +D VSLH+ + +T++++ A+ I+ MKPG+ L+N SRG VV Sbjct: 182 EAVAASGVERASLDELLATADFVSLHIFLDDATRHLIDAEAIATMKPGAYLVNTSRGGVV 241 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL AL L+GA +DV TEP P SPL DN+++T HIG +T E++ Sbjct: 242 DETALAAALREGRLSGAGLDVLETEPL----PPDSPLRGLDNLIITAHIGAATVESRARS 297 Query: 305 GLEVAGKLIKYSDNGSTLSAVN 326 G A +I D + VN Sbjct: 298 GRMAAQAVIDVLDGRTPEHVVN 319 >UniRef50_C9MSC4 Glycerate dehydrogenase n=3 Tax=Prevotella RepID=C9MSC4_9BACT Length = 316 Score = 370 bits (950), Expect = e-101, Method: Composition-based stats. Identities = 97/325 (29%), Positives = 155/325 (47%), Gaps = 19/325 (5%) Query: 11 IKFLLVE----GVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLT 66 +K ++++ + E ++ I E + E +DA I + ++ ++T Sbjct: 1 MKIVILDCHAVNPGDLSWEPIKQLADCTIYERTR---QEDVVERAKDADGILI-NKVNIT 56 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 E+V+ KL IG G N +D+ AA RG+ V N P +T SVA+ V LL Sbjct: 57 EEVLQQLPKLKYIGELATGYNNIDIAAARARGVVVCNIPAYSTDSVAQHVFALLLNAATR 116 Query: 127 VPEANAKAHRGVWNKLAAGSF------EARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 V RG W K + E GK LGI+G GHIG ++ +A ++GM + Y Sbjct: 117 VDHYAEAVRRGEWCKQQDFCYWDTPLIELAGKTLGIVGLGHIGQKVAQIAHAMGMDISAY 176 Query: 181 DIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 +N L + L L + SDV++LH P +M+ A+ + M+PG++LIN R Sbjct: 177 TSKNSTDLPECIRKTTLEGLFSTSDVITLHCPLTAENAHMINAERLQKMRPGTILINTGR 236 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G ++D A+ DAL S HL DV EP + PL + N +TPH+ +T+EA Sbjct: 237 GGLIDEQAVADALESGHLKAYCADVMTDEPPRKDN----PLLQQPNAYITPHVAWATREA 292 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAV 325 +E + + K+ + G+ + V Sbjct: 293 RERLMAIAVENIRKFIE-GTPQNCV 316 >UniRef50_B4AUS0 Glyoxylate reductase n=1 Tax=Cyanothece sp. PCC 7822 RepID=B4AUS0_9CHRO Length = 326 Score = 370 bits (950), Expect = e-101, Method: Composition-based stats. Identities = 86/326 (26%), Positives = 142/326 (43%), Gaps = 11/326 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K + + ++ L L + I + E L E ++ + + E +I Sbjct: 4 PKIFVTRQLPERGLNPLLSHAEIEIWPERQPPAYEILLEKVQQIDGLLCLLTDRIDEQLI 63 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 N + L I +G + +D+ AA R IPV N P T + A+L L+ R + E+ Sbjct: 64 NTGKSLKVISQMAVGYDNIDIKAATNRKIPVGNTPGVLTDATADLTWALLMCAARRIIES 123 Query: 131 NAKAHRGVWNKLAAG---SFEARGKKLGIIGYGHIGTQLGILAESLGMYVYF---YDIEN 184 G W + G LGI+G G IG + A + V + + Sbjct: 124 EQYVRAGSWQTWEPTLLLGTDLSGATLGIVGLGRIGEAVARRASGFNLRVIYSSRHRRSK 183 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 ++ + + LL SD+++LH + T +++ + +LMK ++LIN +RG +V Sbjct: 184 EIEAALGVEYVEFNRLLQESDIITLHTALSKETHHLISYAQFALMKRSAILINTARGAIV 243 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL L S +AGAA+DV EP P SPL N+++TPHIG ++ + + + Sbjct: 244 DPQALYQTLKSGQIAGAALDVTEPEPI----PLDSPLLSLKNLIITPHIGSASYQTRLKM 299 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEV 330 A L+ N VN PE+ Sbjct: 300 ATMAANNLLAGLLNQPLPYCVN-PEI 324 >UniRef50_Q46AE6 Glycerate dehydrogenase n=2 Tax=Methanosarcina RepID=Q46AE6_METBF Length = 323 Score = 368 bits (947), Expect = e-100, Method: Composition-based stats. Identities = 103/325 (31%), Positives = 162/325 (49%), Gaps = 14/325 (4%) Query: 11 IKFLLVEGV--HQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 +K ++ + + ++ + L A G + F E+ +RDA + + R + Sbjct: 1 MKIVVSDSIFLPEEYRKKLDALGDLKV-FESMPSSIEEFISRVRDADIVLV-GRYGFSGK 58 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 NA+ L + + G + +DL AA ++G+ V N P SVAE+V L LLR V Sbjct: 59 AFNASRNLQMLSVWQTGYDHIDLKAATEKGVIVSNVPDYAFDSVAEMVFALALNLLRKVH 118 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVY---FYDIENK 185 A+ + G ++ + GK +G+IG G IG+++ +A M V + + Sbjct: 119 VADIRLREGNFDWRHYFGSQIMGKTMGVIGTGSIGSRVIQIAHGFNMNVISVTGH-PSEE 177 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 + L LL +D+V+LHVP PST+ M+GAKE++ MK ++LIN +RG VVD Sbjct: 178 KARSLGVKFVDLDTLLAEADIVTLHVPLTPSTEKMIGAKELAKMKKSAILINTARGKVVD 237 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL +AL K + GA +DVF EP P PL +NV+LTPHI T+E+ E Sbjct: 238 EAALIEALKEKKIRGAGLDVFEKEPL----PANDPLKALENVVLTPHIAFLTEESLEECT 293 Query: 306 LEVAGKLIKYSDNGSTLSAVNFPEV 330 + ++ + G + VN PEV Sbjct: 294 YVCVQNVERFIE-GKPQNIVN-PEV 316 >UniRef50_A1HSQ7 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Thermosinus carboxydivorans Nor1 RepID=A1HSQ7_9FIRM Length = 317 Score = 368 bits (946), Expect = e-100, Method: Composition-based stats. Identities = 104/321 (32%), Positives = 154/321 (47%), Gaps = 15/321 (4%) Query: 12 KFLLVE---GVHQKALESLRAAGYTNI-EFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 K L+ +A L AG I + L +++L E I+ + + +T Sbjct: 3 KVLVTARSFAKSPEARAVLEQAGCEVIFNPYDRPLTEDELVELIKGMDAL-VAGMDAVTA 61 Query: 68 DVINA-AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 VI A L I +G N +D+ AAA GIPV P +N SVAEL IG +L + R Sbjct: 62 KVIAAGLPTLKIIAKHGVGYNTIDVAAAAAYGIPVTITPGANNISVAELAIGLMLAVARH 121 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL 186 +P+ + RG W++ E GK LGIIG G IG ++ A + GM + YDI + Sbjct: 122 IPQMDGIVRRGGWSR--MTGSELYGKVLGIIGMGSIGCEVAKRAHAFGMKIIAYDIRPRQ 179 Query: 187 PLGNATQVQHL--SDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + V +L +D L +D +SLH P P T M+ + MK + LIN +RG ++ Sbjct: 180 DMIENYGVTYLPMADCLAQADFLSLHAPALPETIGMINKDTLKTMKRTAFLINTARGDLI 239 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 L DAL + +AGA +D F EP + L DNV+LTPH G +T EA + Sbjct: 240 VEEDLYDALKNGVIAGAGLDTFVHEPIR-----DARLFTLDNVVLTPHAGATTHEAVTRM 294 Query: 305 GLEVAGKLIKYSDNGSTLSAV 325 G+ A ++++ + V Sbjct: 295 GVMAAEEVVRVLSGQPPQNPV 315 >UniRef50_A6C2G1 Phosphoglycerate dehydrogenase (SerA) n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C2G1_9PLAN Length = 316 Score = 368 bits (945), Expect = e-100, Method: Composition-based stats. Identities = 106/316 (33%), Positives = 156/316 (49%), Gaps = 10/316 (3%) Query: 13 FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINA 72 L+ E + ++ L + + + + LK+ I++ + +R++T + ++I+A Sbjct: 4 VLVTENIQGVSMNRLIQEHDVEFDAYLWQ-NIDLLKQKIQNTRALIVRNQTKVDRELIDA 62 Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA 132 A +L I G + VD + A ++GI V P +N+ SVAEL IG +L L+R +PEA Sbjct: 63 APELKIIARAGAGLDNVDTEYAHEKGIVVCFTPDANSLSVAELTIGLMLALMRKIPEARQ 122 Query: 133 KAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNAT 192 G WN+L E GK G+IG G IG+ A++ GM + D K Sbjct: 123 DTLTGGWNRLKFTGTELYGKSFGLIGLGRIGSFTATRAKAFGMNILAADPFLKADAPQLK 182 Query: 193 QVQ----HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 ++ L DLL SDVVS H P P T+ M+ + MKP + IN SRG VVD Sbjct: 183 KLNATLLSLDDLLAESDVVSCHSPLTPDTRKMLTYQHFRKMKPDAFFINTSRGEVVDERG 242 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L AL LAGAA+DV TEP SPL + +NV+LTPHI T EAQ+ + V Sbjct: 243 LTQALLEHKLAGAALDVRETEPPKQ-----SPLNQMENVILTPHIAAFTVEAQDRVVDSV 297 Query: 309 AGKLIKYSDNGSTLSA 324 + ++ Sbjct: 298 CEDVRLVLSGKKAINV 313 >UniRef50_B8I0H1 D-3-phosphoglycerate dehydrogenase n=13 Tax=Clostridia RepID=B8I0H1_CLOCE Length = 535 Score = 368 bits (945), Expect = e-100, Method: Composition-based stats. Identities = 101/326 (30%), Positives = 160/326 (49%), Gaps = 11/326 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K ++ E + + + L+ G+ + + E+L E+I D I +RS T + E+++ Sbjct: 1 MKIIVTERIAEDGINYLKENGHEV--DTRYGISHEELLETIEDYDAIIVRSVTKVNEELL 58 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A KL G G + +++ A KRGI V N P SN + AEL +G + R +P+A Sbjct: 59 QRASKLKVAGRAGNGIDNIEVPACTKRGIIVVNTPESNIMAAAELAVGHAYAIFRNIPQA 118 Query: 131 NAKAH-RGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE---NKL 186 + + + + E K GIIG G IG+ + + M V YD K Sbjct: 119 HWAGKAQNDFRRSRFNGNELDEKTAGIIGLGRIGSIVATKLKGSNMKVIAYDPYITDEKF 178 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + L +LL SD++SLH P+ T M+G +++ L K ++NA+RG +V+ Sbjct: 179 KKLGVERCDTLEELLKQSDLISLHTPKTSETYGMIGEEQLKLCKKDVRIVNAARGGLVNE 238 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFT----SPLCEFDNVLLTPHIGGSTQEAQE 302 AL +A+ H+A AA+DV EP + P + L E DNV++TPH+G ST EA Sbjct: 239 EALYNAIKEGHVAAAALDVLDPEPNYDKKPEDQDYQNKLFELDNVIITPHLGASTAEANY 298 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVNFP 328 N+G V+ + AVN P Sbjct: 299 NVGTAVSKLVSDALKGEMVA-AVNMP 323 Score = 45.0 bits (106), Expect = 0.005, Method: Composition-based stats. Identities = 17/75 (22%), Positives = 31/75 (41%) Query: 335 HGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKAL 394 L + + PG++ + I +NIAA + + V + D +V L Sbjct: 459 PTPYVLAIQNVDVPGIIGQIGTILGASDINIAAMQWSRNHKGEKAVAFVSVDCEVPANVL 518 Query: 395 QAMKAIPGTIRARLL 409 + +K I G ++ LL Sbjct: 519 ELLKKINGVLKVTLL 533 >UniRef50_UPI0001BC4ADC hypothetical protein FulcA4_06865 n=1 Tax=Fusobacterium ulcerans ATCC 49185 RepID=UPI0001BC4ADC Length = 319 Score = 367 bits (942), Expect = e-100, Method: Composition-based stats. Identities = 104/321 (32%), Positives = 162/321 (50%), Gaps = 10/321 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K L+ + V ++ +E L++ G+ H +E L + + D I LR+ TE V+ Sbjct: 3 HKVLIPQAVAKEGVELLKSYGFEI--KHGSGASEEDLIKDVADCDAILLRTA-PCTEAVL 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A + L + G N VDL+AAAK GI NAP S T +VAE V+G +L + + + Sbjct: 60 KAGKNLKIVARHGAGYNNVDLEAAAKLGIWATNAPDSTTNTVAEFVLGAILAVSKRIFLM 119 Query: 131 NAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILA-ESLGMYVYFYDIE-NKLP 187 N K G + K + GKKLG++G+G IG ++ A LGM + YD K Sbjct: 120 NKKIKEGDFFFKNNHKGMDLTGKKLGVVGFGRIGRKVAYKAFYGLGMEILAYDPFLTKEN 179 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + + + SD++SLH+P +G KE + MK + IN +RG VV+ Sbjct: 180 CPDYVTICDWETIFKESDIISLHMPLIKENIGCVGKKEFTNMKKSAHFINCARGEVVNEK 239 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 L +AL ++ +AGA +DVF EP + PL DNV++TPH+ +T+E + ++ Sbjct: 240 ELIEALKTEEIAGAFLDVFEQEPPLEDN----PLLSMDNVIVTPHMASNTEECMILMAVQ 295 Query: 308 VAGKLIKYSDNGSTLSAVNFP 328 A +++K N VN P Sbjct: 296 AASEIVKVLSNEKPCWPVNNP 316 >UniRef50_D1U9G1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Desulfovibrio RepID=D1U9G1_9DELT Length = 343 Score = 367 bits (942), Expect = e-100, Method: Composition-based stats. Identities = 84/333 (25%), Positives = 140/333 (42%), Gaps = 13/333 (3%) Query: 9 DKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 K K + + ++ L + L +L S+ D + + + Sbjct: 2 SKPKIFITRRIPDAGIDMLAEVAEVVVNPEDRTLSRAELLASVADCQGVIGLLTEKIDAE 61 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 +AA KL + +G + +D+ A +R IPV N P T + AE + R V Sbjct: 62 FFDAAPKLKGYANYAVGYDNIDVAEATRRSIPVSNTPGVLTDATAECAWALIFATARRVA 121 Query: 129 EANAKAHRGVWNKLA---AGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 EA+ G W RGK LGI+G G IGT + +++ M V + + Sbjct: 122 EADRVMRSGAWQGWGPLQFIGQGVRGKTLGIVGAGRIGTAMALMSRGFDMRVLYTSSSGR 181 Query: 186 ----LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 L ++ LL +D +S+H P P T+++ A MK + ++N +RG Sbjct: 182 RNAVLEDTLKARLVPFDTLLAEADFISIHTPLTPDTRHLFDAAAFGRMKRTACIVNTARG 241 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 V+ L DAL + +AGA +DVF EPA L DN ++ PHIG +T E++ Sbjct: 242 PVIKEDDLVDALKNGVIAGAGLDVFEREPAMAPG-----LAGLDNAVVLPHIGSATVESR 296 Query: 302 ENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPL 334 ++ A ++ + +N P++ P Sbjct: 297 TDMATLAARNMLAMLAGQRPETCLN-PDIFGPA 328 >UniRef50_A9KPU0 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Clostridium phytofermentans ISDg RepID=A9KPU0_CLOPH Length = 316 Score = 366 bits (940), Expect = e-100, Method: Composition-based stats. Identities = 97/318 (30%), Positives = 156/318 (49%), Gaps = 10/318 (3%) Query: 13 FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINA 72 L+ + V + L+ GY ++ E + +I D + LR+ T++V +A Sbjct: 5 ILIPQDVDESGKNYLQEKGYELRILQDSSI--ENICNNIGDCSGLLLRT-VPCTKEVFDA 61 Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA 132 A L IG +G + +D+ A +GI V P +N SVAE I LL + + A+ Sbjct: 62 APHLKVIGRHGVGYDNIDIAEATAQGIKVCYTPLANANSVAEHTIMLLLACAKNIVIADK 121 Query: 133 KAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDI--ENKLPL 188 + +G + + + GK LGIIG+G IG + A LGM + Y E K Sbjct: 122 ELRQGNYEIRNQMPGIDVFGKTLGIIGFGRIGKSVAKKAALGLGMKILAYGRGLEIKEVP 181 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 T ++ + +L+ SD +SLH+P + + M + ++SLMKP ++LIN +RG +V+ Sbjct: 182 DYVTIIKEVDELIRQSDFISLHMPYSKEMQGFMDSTKLSLMKPEAVLINTARGGIVNEDD 241 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L AL + +AGA +DVF EP + S L + DNV++TPH T+EA + L+ Sbjct: 242 LYHALINHKIAGAGLDVFIDEPFKET---LSNLFQLDNVVVTPHSAALTKEAMARMSLDA 298 Query: 309 AGKLIKYSDNGSTLSAVN 326 A + + VN Sbjct: 299 AIGIDEVLSGKKPSWPVN 316 >UniRef50_C5EL38 D-3-phosphoglycerate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EL38_9FIRM Length = 311 Score = 365 bits (938), Expect = 2e-99, Method: Composition-based stats. Identities = 92/302 (30%), Positives = 139/302 (46%), Gaps = 10/302 (3%) Query: 25 ESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEK-LVAIGCFC 83 E L+AAG+ + + Q+ E + + + T++ + + L I F Sbjct: 14 ERLKAAGFQVVRTGERL--PAQIIECGKGCQAAVINAEDQWTKETMEGLKDTLGLIARFG 71 Query: 84 IGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLA 143 +G + VDLDAA GI V N+ +N SVAE + +L R + + K G W K Sbjct: 72 VGLDNVDLDAARGLGIKVANSAGANKESVAECAVTLMLECTRRISWLDGKLRDGQW-KGL 130 Query: 144 AGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA--TQVQHLSDLL 201 + + GK +G+IG+G I + +A+ G V D+ T + +LL Sbjct: 131 PRTHQFSGKTVGLIGFGAIAQCVAGMAKGFGCKVLACDVIKNETAAKRLDTVFCEMDELL 190 Query: 202 NMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGA 261 SD +SLHVP T++M+ + MKP ++LIN SRG VVD AL AL + A Sbjct: 191 EKSDFISLHVPLTEDTRHMVSEAFLKKMKPTAILINTSRGPVVDEKALYRALKEGWIQAA 250 Query: 262 AIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGST 321 +DVF EP + PL N+++TPH ST+EA NI + Y + G Sbjct: 251 GLDVFEQEPPGGDN----PLFGLHNIIVTPHAASSTEEAAGNIADLCMENICSYFETGIP 306 Query: 322 LS 323 Sbjct: 307 KY 308 >UniRef50_Q1K3M3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Desulfuromonas acetoxidans DSM 684 RepID=Q1K3M3_DESAC Length = 528 Score = 363 bits (934), Expect = 5e-99, Method: Composition-based stats. Identities = 101/358 (28%), Positives = 173/358 (48%), Gaps = 7/358 (1%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 ++ L+ + L+ A ++ G + + L + I + + +R T ++E++I Sbjct: 1 MQVLISDNFSSAGLKLFDEAEGITADYQPG-ITHDNLLKIINNYDALIVRGGTTVSEELI 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA++L I IG + +DAA +GI V N P +T ++AE I ++ L R +P+A Sbjct: 60 FAAKRLKIIARAGIGVENIAMDAANIKGIVVTNTPLGSTTTIAEHAIAMMMSLARLIPQA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + +G W + K LG+IG G IG ++ A L M+V YD + Sbjct: 120 HESMSQGKWQSTEFLGSDINDKTLGVIGGGKIGRRVIEYARGLHMHVNLYDPYLSEEVIT 179 Query: 191 ATQV--QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 L DLL+ +D +SLH+P T+ ++ A+ +++KPG LIN + G +++ Sbjct: 180 RLGASKVSLEDLLSTADFISLHLPLTLETEQILNAETFAMVKPGCRLINCALGGLINEDD 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +AL AGAA+D F TEP + L DNV+ TPH+ +T +AQ N+ ++ Sbjct: 240 LVNALTDGTFAGAALDTFATEPPAPDN----RLLHMDNVICTPHLRAATVDAQTNVTVQA 295 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIA 366 A ++I + N + +A+N P +S+ R R G+ A + I Sbjct: 296 AHQVIDFLTNKTVRNALNVPSISIDHLEAMRPYLDMAERMGLFLAQLLHMPFNAITIE 353 >UniRef50_UPI0001972FE9 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=1 Tax=Clostridium sp. M62/1 RepID=UPI0001972FE9 Length = 338 Score = 362 bits (930), Expect = 2e-98, Method: Composition-based stats. Identities = 106/317 (33%), Positives = 152/317 (47%), Gaps = 9/317 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + LL + + + + L GY ++ ++E + IR + +R+ +T+ ++ Sbjct: 3 FRILLPQPILESGRQYLLERGYELVD--GSGFEEEDIIRDIRGCDAMIVRTA-KITDRIL 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA++L I G + VDL+AA K+GI V AP +N++SVAEL + +L R Sbjct: 60 EAADRLKVIARHGAGFDGVDLEAARKKGILVLYAPKANSQSVAELAVFYILHCSRNFKLV 119 Query: 131 NAKAHRG-VWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIENKLPL 188 + K E GK LG+IG G+IG + A M V +D K Sbjct: 120 QKLYRDDYRFAKFNVEKHELNGKTLGLIGVGNIGGLVAKKAALGFDMKVIAFDPYAKELP 179 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + ++ +D VSLHVP P T N +G KE LMKP + LIN SRG+VVD A Sbjct: 180 DYIEVAESREEVFEKADYVSLHVPATPETVNSVGEKEFRLMKPTAFLINTSRGSVVDEEA 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L AL K +AGAA+DV EP + PL E DNV+ PHIG +T+EA L Sbjct: 240 LIRALNEKEIAGAALDVLKQEPIDKDN----PLLEMDNVVTAPHIGAATKEASARASLIC 295 Query: 309 AGKLIKYSDNGSTLSAV 325 A + Y V Sbjct: 296 AQGIDDYLSGRKPEFVV 312 >UniRef50_D1C3Y3 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C3Y3_SPHTD Length = 316 Score = 361 bits (927), Expect = 3e-98, Method: Composition-based stats. Identities = 101/316 (31%), Positives = 161/316 (50%), Gaps = 10/316 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + L+ + + AL+ LR ++ + +L ++L + + + +R T +T +VI Sbjct: 7 PRILVCDPIDDGALDLLRRHARVDV---RTSLAPDELVDIVGGYDGLVVRGTTQITSEVI 63 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA L I + +D+DAA +RGI V ++P + T +VAE+ IG +L +LR +P A Sbjct: 64 EAATALRGIARVGFAVDNIDIDAATERGIVVVHSPGARTYAVAEMTIGLILAVLRHIPAA 123 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + G W + A + RG +G+IGYG IG ++ LA + G V Y + PL + Sbjct: 124 DRSVKAGRWERRAFRGRQLRGATVGVIGYGRIGREVARLAHAFGATVKAY-TQTPRPLEH 182 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 A QV LL SD+++LH +T+ ++ + I M+ G +++N + G ++D AL Sbjct: 183 AKQV-DFQALLASSDIITLHATLTSATRQLINREAIEQMRDGVVIVNTASGGLIDEAALL 241 Query: 251 DALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAG 310 +AL +AGA +DVF EP P L E V+ TP IGGSTQEA + Sbjct: 242 EALDRGKVAGAGLDVFADEP-----PSLRALVEHPRVVTTPRIGGSTQEADRAVSELALQ 296 Query: 311 KLIKYSDNGSTLSAVN 326 L+ AVN Sbjct: 297 SLLAVLRGEQPAVAVN 312 >UniRef50_Q3SK87 D-isomer specific 2-hydroxyacid dehydrogenase n=13 Tax=Bacteria RepID=Q3SK87_THIDA Length = 391 Score = 360 bits (926), Expect = 4e-98, Method: Composition-based stats. Identities = 119/414 (28%), Positives = 193/414 (46%), Gaps = 46/414 (11%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L + + + L L + + + D I +RS ++ Sbjct: 6 KILTLNAISARGLARLPE--HYVVGGD------------LADPDAILVRSANMHEMEI-- 49 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 + AIG GTN + + ++RG+PVFNAP +N +V ELVI +L+ R + A Sbjct: 50 -PTSVCAIGRAGAGTNNIPVKKMSERGLPVFNAPGANANAVKELVIAGMLMGARNLVPAL 108 Query: 132 AKA-----------HRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 K E G+ LG+IG G IG+ + A LGM V Y Sbjct: 109 KFVESLDGTDEAMHKATEAGKKQFAGMELPGRTLGVIGLGAIGSHIAEAAIRLGMNVVGY 168 Query: 181 DIENKLPLG-----NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLL 235 D + + +++ D+L +D V+LHVP +T+N++ A+ +SLM+ G++L Sbjct: 169 DPAITVDAAWRLPSQVKRAENVDDVLRTADFVTLHVPLLDATRNLINAQRLSLMRSGAVL 228 Query: 236 INASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGG 295 +N +R VVD A+ +AL + L D FP + L V+ PH+G Sbjct: 229 LNFAREGVVDNAAVIEALDAGKLHAYICD-FP----------ANALKGHPKVVALPHLGA 277 Query: 296 STQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALN 355 ST+EA+EN + VA +L Y +NG+ L++VNFP V++P RL + N P ++ ++ Sbjct: 278 STEEAEENCAVMVAEQLTDYLENGNILNSVNFPSVAMPRESAFRLAIANANVPNMVGQIS 337 Query: 356 KIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 + A G+NI ++ M Y ++D+ D VA + + AI G + R L Sbjct: 338 SVLAAAGLNIHNMVNKSKGDMAYTLVDV--DSAVAGSVIAQLNAIGGVLGVRYL 389 >UniRef50_B0KD78 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=8 Tax=Bacteria RepID=B0KD78_THEP3 Length = 332 Score = 360 bits (926), Expect = 4e-98, Method: Composition-based stats. Identities = 96/324 (29%), Positives = 153/324 (47%), Gaps = 13/324 (4%) Query: 9 DKIKFLLVEGVHQKAL---ESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 ++K ++ + + E L AG T + +E+L + +DA + + + Sbjct: 2 SQLKVVVTDFEYANLKYEEEVLSKAGITLVPAQCK--TEEELILACKDADGL-INQYAKI 58 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 T VI A +K I + IG + +D+ AA RGI V N P V++ + LL R Sbjct: 59 TRRVIEALDKCKVIARYGIGVDTIDIKAATARGICVVNVPDYCMDEVSDHALALLLGCAR 118 Query: 126 GVPEANAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE- 183 V N G W+ K++ + RGK LG++G+G I L A G + YD Sbjct: 119 KVVLMNNAVKAGTWDFKISKPIYRLRGKVLGLVGFGRIPRTLAEKARPFGFDILVYDPYI 178 Query: 184 -NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 + + L +L++ SD VS+H P T +++G EI LMKP + +IN +RG Sbjct: 179 TQEDVEPYGATLVGLEELMSKSDFVSVHAPLTEKTYHLIGETEIGLMKPSAFIINTARGP 238 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 V+D AL AL K +AGA +DV EP P +PL + DNV++TPH+ ++E++ Sbjct: 239 VIDEKALIKALQEKRIAGAGLDVLEQEP----TPSDNPLLKMDNVIITPHVAWYSEESEA 294 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVN 326 + + A + VN Sbjct: 295 ELRTKAAQGVADVLLGYWPKYLVN 318 >UniRef50_C0CRA6 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=C0CRA6_9FIRM Length = 321 Score = 360 bits (926), Expect = 5e-98, Method: Composition-based stats. Identities = 100/323 (30%), Positives = 150/323 (46%), Gaps = 16/323 (4%) Query: 11 IKFLLV-EGVHQ----KALESLRAAGYTNIEFHKG-ALDDEQLKESIRDAHFIGLRSRTH 64 +K L+ + KALE LR + K L +E+L ++ L Sbjct: 3 MKILVTPTSLQPGRKSKALERLRDFSEELVFNDKSRPLTEEELIPLLKGCQG-YLAGLDF 61 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 +TE V+ AE L I + G +++D+ AA++ G+ V N P N ++V EL G LL + Sbjct: 62 ITERVLREAEDLKVISRYGTGYDRIDMAAASQYGVTVTNTPGVNAQAVGELAFGLLLSVA 121 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI-- 182 R + + G W + E +GK LGI+G G IG + A+ GM V D Sbjct: 122 RQISYLDRTTRSGEWVRAE--GVELKGKTLGILGLGAIGKVVARCAKGFGMRVAASDPFI 179 Query: 183 ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 + + + + + DLL+ +D VSLH+P N T +++G + ++ MK G +LIN SRG Sbjct: 180 DREYCREHGIEAMDMEDLLSFADAVSLHLPLNKETTHLIGKEALARMKDGVILINTSRGG 239 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 ++D A L S + G +D F EP P S L EF NV+ TPH G T+EA Sbjct: 240 IIDEEAAYCGLKSGKIGGLGLDAFENEP-----PKGSSLFEFSNVVATPHTGAHTKEAAS 294 Query: 303 NIGLEVAGKLIKYSDNGSTLSAV 325 + LI V Sbjct: 295 MMAERAVDNLISVLQGERCPYIV 317 >UniRef50_A5W066 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=2 Tax=Pseudomonas RepID=A5W066_PSEP1 Length = 324 Score = 359 bits (922), Expect = 1e-97, Method: Composition-based stats. Identities = 104/322 (32%), Positives = 162/322 (50%), Gaps = 11/322 (3%) Query: 13 FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINA 72 + +H+ L L G + + A+ E+++ + + LR H++ ++I A Sbjct: 4 IYVTSPIHETILSRLSDLGEVRLGYGPNAVAYEEIRNQV---DAVFLRGG-HISAEMIAA 59 Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA 132 + KL + G + VD AAA G+ V N P +N RSV E V LL L R +P A+ Sbjct: 60 SPKLRIVARHGAGYDNVDYKAAADHGVWVTNTPGANQRSVIEHVFALLLSLCRKLPLASE 119 Query: 133 KAHRGVW--NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + VW ++L+ E G+ LG++G+G+IG+ + +AE+ GM V F D + + Sbjct: 120 QTRNRVWAEDRLSLTGIELEGRTLGLVGFGNIGSSVAPVAEAFGMKVIFTDP--AIDPSS 177 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 ++ LL+ +DVVSLHVP +T+N++G E + MK G++LIN SRG VVD AL Sbjct: 178 DSRWVDFDTLLSTADVVSLHVPLLETTRNLIGVPEFAKMKDGAMLINTSRGGVVDEQALV 237 Query: 251 DALASKHLAGAAIDVFPTEPATNSDPFTS---PLCEFDNVLLTPHIGGSTQEAQENIGLE 307 DAL S LAGA DV E PF + N+++T H+ G T E+ +G+ Sbjct: 238 DALKSGKLAGAGADVLAAENIDMIKPFDHDTPDIANTPNLIVTAHVAGQTDESLLRVGMS 297 Query: 308 VAGKLIKYSDNGSTLSAVNFPE 329 + + VN P Sbjct: 298 ALEAIAAVLKGQAPAHPVNQPA 319 >UniRef50_A9A1H5 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=4 Tax=Archaea RepID=A9A1H5_NITMS Length = 310 Score = 358 bits (920), Expect = 2e-97, Method: Composition-based stats. Identities = 110/309 (35%), Positives = 163/309 (52%), Gaps = 10/309 (3%) Query: 13 FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINA 72 L+ + V + L+ G ++ + EQ+ E I D + + +RSRT +T+++I+ Sbjct: 7 VLICDEVDPILNKILQDNGLKI--SYEPEITPEQILEKISDYNIVIVRSRTTITKEMIDK 64 Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA 132 A+ I +G + VD +AA + I V NA +VAELV+G +L L R + Sbjct: 65 ADNCKIIARVGVGLDNVDQEAAKAKNIRVINAVEGAMNAVAELVLGLMLSLARQTARGDR 124 Query: 133 KAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI---ENKLPLG 189 W K E GK LGI+G G+IG +LG LA +L M + YD+ + + Sbjct: 125 GIRNEQWLKKELKGTELAGKYLGIVGLGNIGKRLGRLARALNMNIIGYDVVPIDEEFSKE 184 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 L+ LL +D VS+HVP ST +++ A+++S MK + +IN SRG VVD AL Sbjct: 185 VGLMKADLNTLLQSADYVSIHVPLLDSTYHLLDAQKMSTMKKTAKIINTSRGGVVDEDAL 244 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 DAL + L GAA+DVF EPA + L E DNV+LTPHIG T+EAQ +A Sbjct: 245 YDALKNGTLGGAALDVFEKEPA-----IGTKLAELDNVILTPHIGAQTKEAQSLAANVIA 299 Query: 310 GKLIKYSDN 318 K+++ Sbjct: 300 EKIVQILRG 308 >UniRef50_A9BJ57 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=5 Tax=Thermotogaceae RepID=A9BJ57_PETMO Length = 310 Score = 358 bits (919), Expect = 2e-97, Method: Composition-based stats. Identities = 98/307 (31%), Positives = 162/307 (52%), Gaps = 6/307 (1%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K + + + + AL+ L+ ++E L+ + LK+ I++ + +RS T +T++++ Sbjct: 1 MKIHINDPLDENALKKLQNE-LPDLEITSEHLEKDVLKDKIKEIDVLIVRSATKVTKEIL 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A+KL + +G + +D+D A +GI V N P N+ SVAELVIG +L + R + Sbjct: 60 EHADKLKIVARAGMGLDNIDVDTAKLKGITVLNTPGQNSLSVAELVIGMVLDIYRHITRG 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 W K FE K GIIG+G++G L L + YD+ Sbjct: 120 TIGLKNEQWEKKQLEGFELSQKTFGIIGFGYVGKNLAQLLKGFQTNTLVYDVFEISAEEQ 179 Query: 191 A---TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + L +LL SD++SLH+P+N T + + +I +MK G+++INA+RG V+D Sbjct: 180 KNYNVRQVSLEELLQNSDIISLHIPKNEKTYHFISEPQIKMMKDGAVIINAARGGVLDEN 239 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 + L + L G +DVF EP F L NV+LTPHIG ST+EAQE +G+ Sbjct: 240 YVLKYLKNGKLLGVGLDVFEEEPPKGD--FYKELFALPNVVLTPHIGASTKEAQERVGIN 297 Query: 308 VAGKLIK 314 + ++++ Sbjct: 298 IVDRVVE 304 >UniRef50_D1VVP3 Phosphoglycerate dehydrogenase n=1 Tax=Peptoniphilus lacrimalis 315-B RepID=D1VVP3_9FIRM Length = 315 Score = 358 bits (919), Expect = 3e-97, Method: Composition-based stats. Identities = 111/315 (35%), Positives = 174/315 (55%), Gaps = 11/315 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDD-EQLKESIRDAHFIGLRSRTHLTEDV 69 +K L+++ + ++ + L+ G IEF K L ++L + I D + +R + +D+ Sbjct: 1 MKALIIDQMSEEIDKGLKERG---IEFKKVMLPKKDELIKLIPDVDVLIMRVDPFIDKDI 57 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 ++AA+ L I +GTN +DL+ KR IPV N+P N+ +VAELV + L L R + Sbjct: 58 LDAAKNLKLILVGSVGTNHIDLEECKKRNIPVMNSPGQNSNAVAELVFSKALDLYRNTVQ 117 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKLP 187 AN + G+WNK E R K +GI+GYG IG ++ +A M V YD K Sbjct: 118 ANNEVKSGIWNKYRWIGRELRNKTMGILGYGSIGRRVAEIAHVFKMDVLAYDPYFDPKNN 177 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + ++ L + L SDV++LH+P TKNM+ +K++ M+ G++LINA+RG V+D Sbjct: 178 PYDYVKLVSLDEALKNSDVITLHLPLTKETKNMISSKQMEGMRDGTILINAARGGVIDED 237 Query: 248 ALCDALASKHLAGAAIDVFPTE-----PATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 AL + + + L GA +D E T P +S L E D V ++PHIGGST +AQ+ Sbjct: 238 ALYEYIKNGKLGGANLDTLADELGTGGLDTQDVPISSKLFELDRVYMSPHIGGSTIDAQD 297 Query: 303 NIGLEVAGKLIKYSD 317 +IG V L ++ Sbjct: 298 DIGHLVLQHLDEFLK 312 >UniRef50_B0NG91 Putative uncharacterized protein n=1 Tax=Clostridium scindens ATCC 35704 RepID=B0NG91_EUBSP Length = 319 Score = 358 bits (919), Expect = 3e-97, Method: Composition-based stats. Identities = 97/324 (29%), Positives = 153/324 (47%), Gaps = 15/324 (4%) Query: 10 KIKFLLVE----GVHQKALESLRAAGYTNIEFHKGALD-DEQLKESIRDAHFIGLRSRTH 64 K K ++ +AL L + G DEQ+KE I A + + Sbjct: 3 KYKVIVTARSFAKADDQALRLLEEHDCDVVRLVAGVATFDEQIKEEIAAADAV-IAGLDE 61 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 ++++I+ A KL I + +G ++VD++AA ++GI V P +N SVA+L + +L Sbjct: 62 YSKELIDLAGKLKVISRYGVGYDKVDVEAADRKGILVTITPGANGDSVADLAVTLMLDAA 121 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 R V +A + E K LG+IG G IG + + M + YDI Sbjct: 122 RNVAAMDAAMK--GRAQARPQGVEMWQKTLGVIGTGRIGQGVARRCKGFDMKILCYDIYE 179 Query: 185 KLPLGNA--TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 + LS LL SD +++H P P TK+M+GA+E +MK ++++N +RG Sbjct: 180 NEAFKKECNAKYVDLSTLLRESDFITIHSPLTPETKDMIGAREFDMMKNDAVIVNTARGG 239 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 +++ AL +AL S + GA +D EP P+ SPL N +LTPH G +T+EA Sbjct: 240 IINEEALYEALKSGSIRGAGLDATVDEP-----PYDSPLMTLPNCILTPHAGAATKEASS 294 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVN 326 + L A ++ G VN Sbjct: 295 KMSLMAAQNVVDVLTTGDCKYKVN 318 >UniRef50_C4XIX3 Putative D-isomer specific 2-hydroxyacid dehydrogenase n=1 Tax=Desulfovibrio magneticus RS-1 RepID=C4XIX3_DESMR Length = 329 Score = 358 bits (919), Expect = 3e-97, Method: Composition-based stats. Identities = 88/331 (26%), Positives = 141/331 (42%), Gaps = 12/331 (3%) Query: 6 LEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 + K ++ + + L LR + L ++L +DA + + Sbjct: 1 MTKPLPHVVVTRAIPEAGLALLRERATVWVNPEDRPLTRDELLAQAKDADGVIGLLTDRI 60 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 +A KL + +G + +D+ A +RG+PV N P T++ AEL +L R Sbjct: 61 DAGFFDACPKLRGYANYAVGYDNIDVPEATRRGLPVSNTPDVLTQATAELAFALILATAR 120 Query: 126 GVPEANAKAHRGVWNKLA---AGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVY---F 179 + ++A G W+ + GK LGI G G IG + L+ M + Sbjct: 121 HIVASDAVLRSGQWSGWGPLQFIGTQLAGKTLGIYGPGRIGLAVARLSRGFDMKIITCGG 180 Query: 180 YDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINAS 239 L L +DVVS+ P +T++ A + MKP +LL+N Sbjct: 181 RKPNPALVAEFGAASLPFEAFLAAADVVSITAPLTDTTRHAFNAAAFARMKPTALLVNTG 240 Query: 240 RGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQE 299 RG ++D AL AL +AGA +DV+ EP L NV++TPHIG +T E Sbjct: 241 RGPIIDEAALVVALREGRIAGAGLDVYEFEPRLAEG-----LAALPNVVITPHIGSATTE 295 Query: 300 AQENIGLEVAGKLIKYSDNGSTLSAVNFPEV 330 A+E + + A LI + + + +N PEV Sbjct: 296 AREGMAVLAAQNLIAMLEGTTPPTCLN-PEV 325 >UniRef50_Q71VT7 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=114 Tax=Bacilli RepID=Q71VT7_LISMF Length = 403 Score = 357 bits (917), Expect = 4e-97, Method: Composition-based stats. Identities = 104/372 (27%), Positives = 166/372 (44%), Gaps = 30/372 (8%) Query: 54 AHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVA 113 A I LRS + E + A+ G N + ++ +++GI VFN P +N +V Sbjct: 39 ADGILLRSYNLHD---FDFPETVKAVARAGAGVNNIPVENCSEKGIVVFNTPGANANAVK 95 Query: 114 ELVIGELLLLLRGVPEANAKAHRG----------VWNKLAAGSFEARGKKLGIIGYGHIG 163 ELV+ L + R + E K A E GKKLGIIG G IG Sbjct: 96 ELVLASLFVSARPILEGTEWVKELPAEDDVEQKVEAGKKAFAGTELAGKKLGIIGLGAIG 155 Query: 164 TQLGILAESLGMYVYFYDIENKLPLG-----NATQVQHLSDLLNMSDVVSLHVPENPSTK 218 + A SLGM V YD + + + ++L D +++HVP T+ Sbjct: 156 ALVANDALSLGMDVVGYDPFVSVDTAWRISKEVERAMTIEEVLATCDYLTVHVPLTDKTR 215 Query: 219 NMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFT 278 M A + L+K ++L+N SRG +VD ++ +AL L D E Sbjct: 216 GMFNADTLQLVKDNAVLLNFSRGELVDSASVKEALDDGLLRLYITDFATKE--------- 266 Query: 279 SPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGR 338 L V + PH+G ST+EA+ N A +L Y + GS ++VNFP V +P +G Sbjct: 267 --LLNHKKVHVFPHLGASTEEAETNCAKMAAKELQSYLETGSIKNSVNFPNVEMPYNGHP 324 Query: 339 RLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDV-AEKALQAM 397 R+ H+N P ++ + + +NI ++ + Y +IDI+ + E+ + Sbjct: 325 RIGICHKNIPNMVGQITTELGKYSLNILDMINRSKNEYAYTLIDIDKETQANLEQLKSDL 384 Query: 398 KAIPGTIRARLL 409 A+ G +R R++ Sbjct: 385 LAVQGVLRVRVI 396 >UniRef50_A1HMI9 Phosphoglycerate dehydrogenase n=1 Tax=Thermosinus carboxydivorans Nor1 RepID=A1HMI9_9FIRM Length = 326 Score = 357 bits (917), Expect = 5e-97, Method: Composition-based stats. Identities = 105/324 (32%), Positives = 174/324 (53%), Gaps = 16/324 (4%) Query: 11 IKFLLVEGVHQ---KALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 IK + + V + +ES++ +G T ++ L+D++ ++++ A + + + +T+ Sbjct: 2 IKVIYFDKVFPDMVELIESIKPSGVTVTYWY--TLNDKEKEQALNSADYFLV-ALYKITQ 58 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 ++I A KL I +G + +DL AA GIPV N P N SVAEL +G ++ L R + Sbjct: 59 ELIQKAPKLKMIQKTGVGVDNIDLAAAKTLGIPVANTPGGNATSVAELTLGMIINLYRKI 118 Query: 128 PEANAKAHRGVWNKLAAG--SFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 + + +G W S+E +GK GIIG+G+IG ++ L+++ G V +YD+ Sbjct: 119 NILDRETKKGNWMSWEFRPSSYEVKGKTHGIIGFGNIGREVARLSQAFGTNVIYYDLRRL 178 Query: 186 LPLGNA---TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 P L++LL SD++S+H+P P TKN++ +E++L+KP +LLIN +RG Sbjct: 179 EPAEEKRLNVTYHELNELLQKSDIISIHLPLTPDTKNLISERELALLKPTALLINVARGN 238 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 +VD AL AL L GA IDV+ EP +PL +NVL TPHIG T++ + Sbjct: 239 IVDEVALYRALKENKLLGAGIDVWSKEPVE-----DNPLLTLNNVLATPHIGAGTRDTLQ 293 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVN 326 + +I + + VN Sbjct: 294 TVLGLAFENIIATTRGKNPRFVVN 317 >UniRef50_A9A5A9 Glyoxylate reductase n=2 Tax=Thaumarchaeota RepID=A9A5A9_NITMS Length = 322 Score = 357 bits (916), Expect = 5e-97, Method: Composition-based stats. Identities = 90/323 (27%), Positives = 141/323 (43%), Gaps = 11/323 (3%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 + K L +H AL+ L+ + K + +L+ I+D + + ++ Sbjct: 2 RKKVFLTRTLHDFALKELKKKYQIEVHKGKIPVPQSKLRSKIKDVDGLICFPYDIINKET 61 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I+ AE L I + +G + +D A + I V P T + A+L LL LR V E Sbjct: 62 IDLAENLKVISTYSVGFDHIDTKYAKGKKIRVGYTPEVLTDATADLAFSLLLDSLRRVSE 121 Query: 130 ANAKAHRGVWN----KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN- 184 + G W + +GK +GI+G G IG L A++ M + +++ Sbjct: 122 GDRIIRDGKWKMIYGAHDYVGVDLQGKTIGILGLGRIGQTLAKRAKAFDMDIIYHNRNRL 181 Query: 185 --KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 + L++ SDV+S+HVP T M K MK + LIN SRG Sbjct: 182 SKTKERTLDAKYVSFERLISQSDVISIHVPHTKETDKMFNMKIFKKMKNTAFLINTSRGK 241 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 VV+ L AL K +AGA +DVF EP + + PL + NV+L PHIG ST+E + Sbjct: 242 VVNEKDLVTALKKKIIAGAGLDVFEQEPISKN----HPLTKLQNVVLAPHIGSSTKETRA 297 Query: 303 NIGLEVAGKLIKYSDNGSTLSAV 325 + L + + +V Sbjct: 298 KMAEITVRNLNLGMNGKKPIYSV 320 >UniRef50_Q0W672 Glycerate dehydrogenase n=2 Tax=Archaea RepID=Q0W672_UNCMA Length = 319 Score = 357 bits (916), Expect = 7e-97, Method: Composition-based stats. Identities = 102/320 (31%), Positives = 151/320 (47%), Gaps = 11/320 (3%) Query: 13 FLLVEGVHQKAL--ESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 ++ + V + L G + + L E+ I +A + S L Sbjct: 4 IVIADAVSKHELYEHHFGKIGDLKV-YRGPPLSMEEYLCRIAEADVAVV-SHFKLPARSF 61 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +++ L + G + VDLDAA +G+ V NAP + +VAE V LL +R + EA Sbjct: 62 DSST-LKLVALTRTGYDDVDLDAATLKGVAVANAPGYSNEAVAEHVFAMLLSFIRRISEA 120 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + ++ A E RGK +GIIG G IG ++ +A GM V YD+ + Sbjct: 121 DFWIREEKFDCTAFEGRELRGKTMGIIGTGQIGLRVAEIARCFGMDVIAYDVRRNPAVAE 180 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 + L L SD +++H+P T+ ++ + LMKPG+++IN +RG VVD AL Sbjct: 181 KLRYVGLDRLCAESDFITVHLPLTSDTRGLIDEESFRLMKPGAVIINTARGPVVDQAALL 240 Query: 251 DALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAG 310 AL +AGA +DVF EP P SPL N LLTPHI +T+EA+E A Sbjct: 241 RALDEGRIAGACLDVFDQEPL----PPDSPLLAMSNTLLTPHIAYNTREAKEQSIAIAAE 296 Query: 311 KLIKYSDNGSTLSAVNFPEV 330 + Y G + VN P V Sbjct: 297 NVALYLS-GKPRNIVN-PAV 314 >UniRef50_A7VV70 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753 RepID=A7VV70_9CLOT Length = 316 Score = 356 bits (914), Expect = 9e-97, Method: Composition-based stats. Identities = 97/326 (29%), Positives = 151/326 (46%), Gaps = 20/326 (6%) Query: 11 IKFLLVE----GVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLT 66 +K ++++ + E L G + E+L E ++A + + ++T L+ Sbjct: 1 MKIVVLDGETTNPGDLSWERLEKLGELTVY---ARTKPEELYERAKEAE-LLITNKTVLS 56 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 +I + + L IG G N VD+ AA K GIPV N P T +VA++ L L Sbjct: 57 GKMIRSLKNLKYIGTLSTGFNVVDIHAARKLGIPVCNVPSYCTNAVAQMTFSLLFALTNH 116 Query: 127 VPEANAKAHRGVWNKLAAGSF------EARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 V N H+G W + E K G+ G+G IG + +A LGM V Y Sbjct: 117 VALHNHSVHQGDWENSTDFCYWKAPLVELESKNFGVYGFGSIGRTVAKIAADLGMNVLVY 176 Query: 181 DIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 K + + + +L SDV+SLH P P T ++ K +SLMKP + LIN SR Sbjct: 177 SRTKK-DMPSGYRWVSQEELFRESDVLSLHCPLTPETTGLVNRKTLSLMKPTAYLINTSR 235 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G V+ L +AL LAGAA+DV EP +P T + ++TPHI + +E+ Sbjct: 236 GQVIREQDLAEALNGGRLAGAAMDVLCEEPPEKGNPLTH----CEKCVITPHISWAAKES 291 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVN 326 ++ + V + + G+ + VN Sbjct: 292 RDRLLHTVCDNVEAFLK-GTPQNQVN 316 >UniRef50_A7NS02 Glyoxylate reductase n=8 Tax=Bacteria RepID=A7NS02_ROSCS Length = 341 Score = 355 bits (913), Expect = 1e-96, Method: Composition-based stats. Identities = 96/330 (29%), Positives = 148/330 (44%), Gaps = 17/330 (5%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKG-ALDDEQLKESIRDAHFIGLRSRTHLTED 68 + + L + Q A++ + AA T + + E L ++ + I + + Sbjct: 2 RPRVYLTRRLPQAAVDIVTAACETTFWDDEALPVPRETLLRAVAEVDGILTLLTDRVDVE 61 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 +++AA +L + +G + VDL A RG+ + N P T + A+LV +L R V Sbjct: 62 LLDAAPRLKVVANMAVGYDNVDLPALTARGVLLTNTPDVLTETTADLVWALILAASRRVV 121 Query: 129 EANAKAHRGVWNKLAAG---SFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 E + G W+ + + G LGI+G G IG + A GM + +++ Sbjct: 122 EGHRLIAAGGWSTWSPMFMVGQDVHGATLGIVGAGRIGAAVARRAVGFGMPILYHNRHPS 181 Query: 186 LPLGNATQ---------VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLI 236 L + V +L DLL SDVV + VP P T+ M GA+E +LMKP S+ + Sbjct: 182 PALEAQIRATPGAAIRYVPNLDDLLTESDVVVVMVPLTPETRGMFGAREFALMKPTSVFV 241 Query: 237 NASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGS 296 NASRG V+ L DAL A +DVF EP PL NV+LTPHIG + Sbjct: 242 NASRGPVIREAELIDALQRGRPWAAGLDVFEREPIGAD----HPLLTLPNVVLTPHIGSA 297 Query: 297 TQEAQENIGLEVAGKLIKYSDNGSTLSAVN 326 T + + + A L+ + VN Sbjct: 298 TVATRTRMAVVAATNLVAALTGQPVPNPVN 327 >UniRef50_B8FRV3 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Desulfitobacterium hafniense RepID=B8FRV3_DESHD Length = 320 Score = 354 bits (910), Expect = 3e-96, Method: Composition-based stats. Identities = 100/311 (32%), Positives = 151/311 (48%), Gaps = 11/311 (3%) Query: 18 GVHQKALESLRAAGYTNIEFHKGALDD-EQLKESIRDAHFIGLRSRTHLTEDVINAAEKL 76 +A L G + L + E K + +AH + + + + AA L Sbjct: 15 KYSPQAAGILEKKGCRLVMIPPNGLREREDFKAVLAEAHVWVV-GINKVYAEDLEAAPNL 73 Query: 77 VAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHR 136 I G + +DL AAA RGI V NAP +N SVA+L G +L L R + A+ + Sbjct: 74 KLIIKHGTGVDSIDLKAAAARGITVANAPGTNANSVADLAFGFMLSLARQIVSADKRTRD 133 Query: 137 GVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQ- 195 G W + GK LG++G G IG + A M + YD+ + +V+ Sbjct: 134 GFWG--TVMGKDVYGKTLGVLGLGQIGKGVIRRASGFDMNILGYDLVHHSQFEKEYRVRA 191 Query: 196 -HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALA 254 L ++++ +D +S+H+P STKN++ + M+P + LIN SRG VVD AL D L Sbjct: 192 ATLEEIMSEADYISVHLPLLESTKNIIDRSLLEKMRPTAFLINTSRGGVVDETALYDLLK 251 Query: 255 SKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIK 314 K +AGAA+DVF TEP P SP E DNV++ PH+G T+ A + +A +++ Sbjct: 252 EKRIAGAALDVFATEP-----PRQSPFFELDNVIVAPHMGAYTEGAMGAVSEILAESIVR 306 Query: 315 YSDNGSTLSAV 325 LS + Sbjct: 307 VLAGKEPLSVI 317 >UniRef50_C4ZHF5 Phosphoglycerate dehydrogenase, putative n=3 Tax=Clostridiales RepID=C4ZHF5_EUBR3 Length = 329 Score = 354 bits (910), Expect = 3e-96, Method: Composition-based stats. Identities = 95/318 (29%), Positives = 156/318 (49%), Gaps = 12/318 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +KF++ + V + ++ L G ++ D + +RDA + +R + I Sbjct: 1 MKFVMTQAVCPEGMQLLD--GIADVYVADNQ-DPNNYLDEMRDAAALIVRIA-KCDANAI 56 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 + KL IG +G + VD+ A + GIPV P +N RSVAE + + L + + EA Sbjct: 57 ENSPKLKVIGRTGVGYDSVDVKKATELGIPVVITPGANNRSVAEHAVAMIFALSKNLIEA 116 Query: 131 NAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI---ENKL 186 + +G W + A +FE K +GI+G G IG + + + GM + YD + ++ Sbjct: 117 QNEMCKGNWEIRGAKKAFELERKTVGILGLGAIGRETAKICKGCGMRIAAYDPFMTKEQV 176 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 A + +LL SDVVS+HVP T+NM+ KE+S+MKP +L+IN SRG +++ Sbjct: 177 EGYGAKYYEDYVELLKDSDVVSIHVPLTDQTRNMISKKELSVMKPTALIINCSRGGIINE 236 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 L +AL + +AGA DVF +EP D PL N++++PH T+EA + Sbjct: 237 ADLVEALNNGVIAGAGTDVFCSEPPKTDD----PLLNCRNLIVSPHSAAQTREAVIKMAQ 292 Query: 307 EVAGKLIKYSDNGSTLSA 324 + + Sbjct: 293 MCIKGCLAVVEGKKWPYV 310 >UniRef50_O32264 Probable 2-ketogluconate reductase n=7 Tax=Bacillales RepID=TKRA_BACSU Length = 325 Score = 353 bits (907), Expect = 7e-96, Method: Composition-based stats. Identities = 82/322 (25%), Positives = 144/322 (44%), Gaps = 13/322 (4%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGL--RSRTHLTE 67 K + + + ++ + + + + L + L E +++A + S + Sbjct: 3 KPFVFITKPIPEEIEAFIGEHCRYEV-WQEDTLPSDVLFEKLKEAEGLLTSGTSGPSINR 61 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 +++ A KL + +G + D++A +RG+ + P++ +VA+L +L R V Sbjct: 62 ELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTLDDTVADLAFSLILSSARRV 121 Query: 128 PEANAKAHRGVW---NKLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIE 183 E + G W + A + + LGIIG G IG Q A+ M V +++ Sbjct: 122 AELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIGEQAARRAKFGFDMEVLYHNRH 181 Query: 184 NKLPLGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 K + + L LL SD + L P T +M+G +E LMK ++ +N SRG Sbjct: 182 RKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETYHMIGEREFKLMKNSAIFVNISRG 241 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 VD AL AL + GA +DV+ EP T + PL + DNV L PHIG +T + + Sbjct: 242 KTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDN----PLLQLDNVTLLPHIGSATAKVR 297 Query: 302 ENIGLEVAGKLIKYSDNGSTLS 323 N+ + A ++ + + Sbjct: 298 FNMCKQAAENMLAAIQGQTPKN 319 >UniRef50_B0PD17 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PD17_9FIRM Length = 388 Score = 353 bits (907), Expect = 8e-96, Method: Composition-based stats. Identities = 104/413 (25%), Positives = 180/413 (43%), Gaps = 45/413 (10%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + + ++ + Y + + + I +RS ++ Sbjct: 3 HIKTLNKISPYGMDVFDRSKYICGDHVEAP-------------NGILVRSAAMHDMEL-- 47 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 +L AI G N + +D +++GI VFN P +N +V ELVI LL+ R V A Sbjct: 48 -GPELAAIARAGAGVNNIPVDRCSEQGIVVFNTPGANANAVKELVICALLMSARRVFPAM 106 Query: 132 AKAH--RGVWN---------KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 +G + K E GK LG+IG G IG ++ A L M V+ Y Sbjct: 107 EWVQTLKGQGDEVPKLVEKGKSQFVGPELAGKSLGVIGLGAIGARIANFARHLDMEVWGY 166 Query: 181 DIENKLPLG-----NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLL 235 D + + + L ++ D ++LH+P P TK M+ ++ I +M+ G L Sbjct: 167 DPYMSVETAWNVSRSIRRASSLKEIYENCDFITLHIPSTPETKGMINSQSIQMMRHGVRL 226 Query: 236 INASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGG 295 +N +RG ++ L L K + D FP + L V+ PH+G Sbjct: 227 LNFARGDLIVNEDLLAGLEEKQIRCYFTD-FP----------SDELLGHPGVMAIPHLGA 275 Query: 296 STQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALN 355 ST E+++N A +L+ Y +NG+ ++VN P VS+P G R+ IH N P +LT ++ Sbjct: 276 STPESEDNCARMAAEELVDYLENGNIKNSVNMPSVSMPRSGDFRVALIHRNIPAMLTKIS 335 Query: 356 KIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARL 408 + ++ G+NI ++ Y +ID++ ++ ++A+ IR + Sbjct: 336 VLISDAGMNIENLTNKSRQNYAYTMIDLKG--APTDELAAKLRAVEDVIRVTI 386 >UniRef50_UPI000197AFFA hypothetical protein BACCOPRO_00987 n=1 Tax=Bacteroides coprophilus DSM 18228 RepID=UPI000197AFFA Length = 315 Score = 353 bits (906), Expect = 8e-96, Method: Composition-based stats. Identities = 109/316 (34%), Positives = 161/316 (50%), Gaps = 12/316 (3%) Query: 11 IKFLLVE--GVHQKAL----ESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTH 64 + +L+E G+ + L L AG+T + LD + E R+A I + + Sbjct: 1 MNIVLLESLGISPERLSEYARPLVEAGHTF-NAYPRDLDIQVQIERAREADVIIIAN-MP 58 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 L +VI A + L I G + VDLDAA + G+ V NA +T++VAEL + +L LL Sbjct: 59 LRGEVIRACKHLKFIDVAFTGVDHVDLDAARECGVKVSNAAGYSTQAVAELALCMMLSLL 118 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 R VP+ + +G K E RGK +GI+G G IGT+ L ++ G V Sbjct: 119 RNVPQVAGRCRQGK-TKDGLVGCELRGKTVGIVGAGAIGTRTAELCKAFGCRVLGNKRHL 177 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + + L +LL+ SD+VSLH P T+ ++ A + +MK G+ LIN +RG VV Sbjct: 178 TGKEPSFIEFMPLEELLSQSDIVSLHCPLTAETRQLINADRLGMMKQGAYLINTARGGVV 237 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL +AL + +LAGA IDVF TEP + PL + NVL TPH+ +++E+ E Sbjct: 238 DSAALAEALKNGYLAGAGIDVFETEPPLDP---AHPLLQAPNVLATPHVAFASEESMEAR 294 Query: 305 GLEVAGKLIKYSDNGS 320 V L + D Sbjct: 295 AAIVFSNLSNWMDGKQ 310 >UniRef50_C1A4S7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1A4S7_GEMAT Length = 534 Score = 352 bits (904), Expect = 2e-95, Method: Composition-based stats. Identities = 100/320 (31%), Positives = 163/320 (50%), Gaps = 8/320 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + L+ + V Q+ + L A ++ L ++L I + I RS T ++ +++ Sbjct: 2 FRVLVTDEVDQEGVVLLTAEPALQVD-ELPTLPKDELLRRIGEYDAIVGRSATRISAELL 60 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A KL +G +G + ++LD A GI + NAP NT +VAEL G ++ LLR + A Sbjct: 61 KAGGKLKVVGRAGVGVDNIELDVATSLGIAIINAPAGNTVAVAELFFGTVIGLLRQLHTA 120 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE---NKLP 187 A G W++ E +GK LGI+G G IG+++ A + GM V YD + Sbjct: 121 AAAMGDGRWDRAKFMGRELKGKTLGIVGLGRIGSEVAARAHAFGMTVVAYDPYIADERFA 180 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + L LL ++V++LHVP T+ M+G +E++ + S+++N +RG V++ Sbjct: 181 ALRVRRAPSLDALLAETNVLTLHVPLTDETRGMIGKRELARLPARSVVVNLARGGVIEEA 240 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL AL + L GA +DVF EP SPL N++LTPH+G +T EAQ N+ + Sbjct: 241 ALQAALETDQLRGAVLDVFTVEPLAPD----SPLRNIPNLVLTPHLGANTVEAQRNVSRD 296 Query: 308 VAGKLIKYSDNGSTLSAVNF 327 V + + ++N Sbjct: 297 VCVAVRDALLHNDLSRSINV 316 >UniRef50_Q7WEA3 Phosphoglycerate dehydrogenase n=1 Tax=Bordetella bronchiseptica RepID=Q7WEA3_BORBR Length = 329 Score = 351 bits (903), Expect = 2e-95, Method: Composition-based stats. Identities = 110/317 (34%), Positives = 159/317 (50%), Gaps = 13/317 (4%) Query: 14 LLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAA 73 ++ + VH + LRAAG T IE LD L++ I A + +R L ++I+ A Sbjct: 5 VIAQPVHPVGPQLLRAAGITVIEPAGPGLD--ALRQVIAGADAVLVR--DQLPAELIDMA 60 Query: 74 EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAK 133 +L I GT+++ + A GIPV P +N RSVAE + +L+ R +A+A Sbjct: 61 PRLCVIANHGTGTDKIAVAHADALGIPVVYTPQANVRSVAEHALMLMLVTARQAVQADAA 120 Query: 134 AHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIE---NKLPL 188 +G W K + GK LG+IG G G L +A +L M + + Sbjct: 121 TRKGHWGFKYEQPMYSLYGKTLGVIGLGRTGRLLCEMAAPALNMQALVWSPSLPAGEALP 180 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 A +V L +LL +DVVSLH P P T++ + A ++ MKPG+++IN SRG ++D A Sbjct: 181 PGARRVDTLQELLREADVVSLHRPLRPDTRHTLDAATLACMKPGAIVINTSRGGLIDEAA 240 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L DAL LAGA +DVF TEP P S + N +LTPH+ GSTQEA + Sbjct: 241 LADALREGRLAGAGLDVFETEPL----PAGSRVAGLPNAVLTPHVAGSTQEALHATASQC 296 Query: 309 AGKLIKYSDNGSTLSAV 325 A ++I V Sbjct: 297 AEQIIAVLAGRRPPHLV 313 >UniRef50_A0Q365 D-isomer specific 2-hydroxyacid dehydrogenases n=11 Tax=Bacteria RepID=A0Q365_CLONN Length = 317 Score = 351 bits (902), Expect = 3e-95, Method: Composition-based stats. Identities = 105/321 (32%), Positives = 158/321 (49%), Gaps = 13/321 (4%) Query: 11 IKFLLVEGVHQKALES------LRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTH 64 ++ ++E + E + G+ I F D + L E +DA + L + Sbjct: 1 MRISVLEPLGLPKEEVYSIAKPIIDKGHEVILFEDKVQDKKVLMERAKDAEVLVLAN-MP 59 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 L +VI + +KL I G + VD A ++ + V NA +T SVAEL G + +L Sbjct: 60 LEGEVIKSDDKLKMISVAFTGIDHVDTKACTEKQVMVCNAAGYSTSSVAELTYGLIFSVL 119 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI-E 183 R + + G + E GK +GI+G G IG ++G +A++ G V Y E Sbjct: 120 RNIVPLDKATREGK-TRNGFSQNEILGKTIGIVGTGAIGIRVGQIAKAFGCNVLAYSRSE 178 Query: 184 NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 K + + L +LL+ SD+VSLHVP N TK ++ ++I LMK S+LIN +RG V Sbjct: 179 RKEAIDTGFKYVSLDELLSKSDIVSLHVPLNDETKGLISKEKIELMKSSSILINTARGPV 238 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 VD AL +AL + GA IDVF EP + + PL NV++TPHI +T+EA Sbjct: 239 VDNSALAEALKKGKIKGAGIDVFEIEPPISKE---HPLFNAPNVVVTPHIAFATEEAMYR 295 Query: 304 IGLEVAGKLIKYSDNGSTLSA 324 V + K+ D GS + Sbjct: 296 RCEIVFKNIEKWLD-GSPQNV 315 >UniRef50_A5N5A9 SerA n=3 Tax=Clostridium RepID=A5N5A9_CLOK5 Length = 320 Score = 351 bits (902), Expect = 3e-95, Method: Composition-based stats. Identities = 102/320 (31%), Positives = 160/320 (50%), Gaps = 11/320 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ E + ++ +E L+ GY ++ L E ++D I +R ++TE VI Sbjct: 4 KILITESIEEEGVEYLKKFGYEI--KMPRDTSEDVLIEEVKDCDAILVR-MANITEKVIR 60 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A +KL I F +G N VD+ A++ I + NAP SN +VAE +G ++ L + + Sbjct: 61 AGKKLKVISRFGVGVNNVDIKTASELSIQITNAPESNKNTVAEYTMGLIIALAKKFFLYD 120 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILA-ESLGMYVYFYDIENKLPLGN 190 +G + + GK LGI+G G IG L + A + GM V + + Sbjct: 121 RGLRKGNFKVRDILGIDLEGKVLGIVGLGSIGKLLALKASKGFGMKVIGFKRHIDEESKS 180 Query: 191 ATQVQ---HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 V+ L +L SD VSL+VP +T ++G +E+S MK + LIN +RG VVD Sbjct: 181 LDYVELTDSLDYVLENSDFVSLNVPLTKATTKIIGKRELSFMKKDAFLINTARGEVVDND 240 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 ALC+AL +K +AGAA DVF E + + P+ + +NV++TPH T EA + + + Sbjct: 241 ALCNALLNKQIAGAATDVFDGEIPSKDN----PIFKMENVIVTPHSAAHTIEAMKRMSVH 296 Query: 308 VAGKLIKYSDNGSTLSAVNF 327 A + + VN Sbjct: 297 AAIGIHEVLSGNKPSWPVNI 316 >UniRef50_Q04AA8 Lactate dehydrogenase related enzyme n=3 Tax=Firmicutes RepID=Q04AA8_LACDB Length = 316 Score = 351 bits (901), Expect = 3e-95, Method: Composition-based stats. Identities = 93/320 (29%), Positives = 152/320 (47%), Gaps = 13/320 (4%) Query: 11 IKFLLVEG--VHQKAL----ESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTH 64 +K +L+E + Q++L E L G+ + + D E+LK+ DA + + + Sbjct: 1 MKIVLLEPLGISQESLDKLAEKLTKQGHEFTAYDSFSTDTEELKKRSEDADALIIANH-L 59 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 L +VI A + L I +G + VDL+A ++ I + N +VAEL IG L L Sbjct: 60 LPGEVIRADKNLKFISVAFVGIDHVDLEACKEKKINISNTGGYCNDAVAELAIGLTLDCL 119 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 R + N G K E GK +GI+G G IG + + ++ G + Y Sbjct: 120 RKISAGNEAVQAGE-GKGGLQGHELAGKTVGIVGTGAIGCRTAEIFKAFGCKLIGYSRSQ 178 Query: 185 KLPLGN-ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 K + + + L +++ +D+VS+H P P TK ++G KEI MK G++LIN +RG V Sbjct: 179 KAAALDLGLEYKSLDEVMGEADIVSIHTPLTPETKGLIGKKEIGEMKEGAILINTARGPV 238 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 VD AL AL + A +DVF +P P PL N++ +PH+G T+E+ + Sbjct: 239 VDTEALAAALKEGRIK-AGLDVFDQDPPL---PADYPLLGVPNLVCSPHVGFDTKESIDR 294 Query: 304 IGLEVAGKLIKYSDNGSTLS 323 + + + + Sbjct: 295 RAEMAFENVTAWLNGQQIRT 314 >UniRef50_A6Q7Q2 D-3-phosphoglycerate dehydrogenase n=49 Tax=Epsilonproteobacteria RepID=A6Q7Q2_SULNB Length = 529 Score = 350 bits (900), Expect = 5e-95, Method: Composition-based stats. Identities = 109/364 (29%), Positives = 180/364 (49%), Gaps = 10/364 (2%) Query: 9 DKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 K ++ + +HQ L+ L + D+ + E I A RS T + Sbjct: 2 SKKTIVVCDHIHQSGLDILANDSEIKLINAADEPKDKLIAEIIPLADVAITRSSTDVDAA 61 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 + +A+K+ AI +G + VD+ ++K+GI V N P +NT + EL + +L +R P Sbjct: 62 FLESAKKITAIVRAGVGVDNVDIPGSSKQGIVVMNVPTANTIAAVELTLAHMLSCVRQFP 121 Query: 129 EANAKAH-RGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE---N 184 A+ VW + E + KKLGIIG+G+IG+++G A++ M V YD + Sbjct: 122 YAHNNLKLDRVWRRQDWYGTELKDKKLGIIGFGNIGSRVGKRAKAFEMDVLAYDPYIDPS 181 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 K + ++ D+L D++++H P+ T M+ EI+ MK G +LIN +RG + Sbjct: 182 KATDLDIGYTKNFEDILA-CDIITIHTPKTEETIGMINKDEIAKMKDGVILINCARGGLY 240 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 + AL + L S +A A IDVF EPAT PL + DNV +TPH+G +T+E+Q NI Sbjct: 241 NEEALLEGLKSGKIAMAGIDVFNKEPAT-----DHPLLDLDNVTVTPHLGANTKESQRNI 295 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVN 364 ++ A I + + +A+N P L R + G L++ A + + Sbjct: 296 AIQAAENAIAAAKGIAYPNALNLPIKENELPDFVRPYLELIQKMGHLSSQVTKSAVKSIK 355 Query: 365 IAAQ 368 + A+ Sbjct: 356 VTAK 359 >UniRef50_B2I1D3 Phosphoglycerate dehydrogenase n=2 Tax=Acinetobacter baumannii RepID=B2I1D3_ACIBC Length = 325 Score = 350 bits (899), Expect = 5e-95, Method: Composition-based stats. Identities = 101/320 (31%), Positives = 159/320 (49%), Gaps = 12/320 (3%) Query: 10 KIKFLLVEG-VHQKALESLRAAGYTNIEFHKGALDDEQLKESIRD--AHFIGLRSRTHLT 66 K K L+ + AL ++ I + +++++ I D I +R+ L+ Sbjct: 2 KRKVLITGPTLTSDALLYAQSHDIQLIPTEPY-MAKDKMEKLIHDEQPDAIIVRTG-KLS 59 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 D+I A++ L I +G + +D AAA+R IPV A +N +SVAE + + R Sbjct: 60 RDMIFASDNLKVIAKHGVGFDTIDTQAAAERKIPVTIAVGANAQSVAEHAFALMFNVARQ 119 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--EN 184 V + + G W+K +A E GK LG+IG G IG+ L L L M V YD +N Sbjct: 120 VTWLDQRIREGHWDKASANGVELYGKTLGLIGLGAIGSILMKLVAPLNMKVKVYDPFLQN 179 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 L Q L+ SD++SLH P K++ + MK S+LIN +RG ++ Sbjct: 180 LPELDYVEQEHDFEKLIETSDIISLHCPLTAENKHLFSHSQFEKMKSSSILINTARGELI 239 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL DAL + +AGA +D F +EP + PL E N+++TPHIG +T +++ + Sbjct: 240 DQAALVDALKNNKIAGAGLDTFSSEPPEKDN----PLWELPNLVVTPHIGANTTDSRNRV 295 Query: 305 GLEVAGKLIKYSDNGSTLSA 324 GL +++ NG L+ Sbjct: 296 GLLALEQIMSIW-NGQLLNP 314 >UniRef50_Q0AFR7 D-3-phosphoglycerate dehydrogenase n=22 Tax=Bacteria RepID=Q0AFR7_NITEC Length = 405 Score = 349 bits (897), Expect = 9e-95, Method: Composition-based stats. Identities = 115/423 (27%), Positives = 189/423 (44%), Gaps = 46/423 (10%) Query: 4 VSLEKDKI-KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSR 62 +S + KI K L + + L+ L A + Q+ I D I +RS Sbjct: 1 MSEDIQKICKVLTLNSIASVGLKRLPANIF-------------QISSDISDPDVILVRSH 47 Query: 63 THLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLL 122 ++ ++AIG GTN + ++ + RGIPVFN P +N +V ELV+ +L+ Sbjct: 48 NMHD---MDIPVSVIAIGRAGAGTNNIPVNQMSARGIPVFNTPGANANAVKELVLAGMLM 104 Query: 123 LLRGVPEANAKAHRGVWN-----------KLAAGSFEARGKKLGIIGYGHIGTQLGILAE 171 R + A + K E G+ LG+IG G IG + A Sbjct: 105 ASRNLIPALRFVEALEGDDQSFHLQVEAGKKQFSGLELPGRTLGVIGLGKIGRPVADAAI 164 Query: 172 SLGMYVYFYDIENKLPLG-----NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEI 226 LGM V YD + + + + DL+ S+ +SLHVP N ST++++ I Sbjct: 165 KLGMKVLGYDPKITIDSAWSLSAEVQRANQIEDLVRRSNFISLHVPLNESTRHLINGPLI 224 Query: 227 SLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDN 286 S M+ ++L+N SR +VD A+ + S + D FP L + Sbjct: 225 SHMQKNTILLNFSRNAIVDEDAVLAGIKSGIIKNYVCD-FP----------DQKLKQQPA 273 Query: 287 VLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHEN 346 V+ PH+G ST EA+EN + +A +++ Y +G+ VNFP+V + R+ + N Sbjct: 274 VITLPHLGASTHEAEENCAMMIADQIMDYIAHGNISYTVNFPDVVMERGTPFRVAVANAN 333 Query: 347 RPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRA 406 P +L ++ A+ G+NI ++ +M Y ++D D V + + A+ I G + Sbjct: 334 VPNLLGQISTRMADIGLNIHNMINKSRGEMAYTLVD--TDRAVPPEIINAIAQITGVLMV 391 Query: 407 RLL 409 R L Sbjct: 392 RYL 394 >UniRef50_C2HJZ3 Possible glyoxylate reductase n=2 Tax=Finegoldia magna RepID=C2HJZ3_PEPMA Length = 313 Score = 349 bits (897), Expect = 9e-95, Method: Composition-based stats. Identities = 96/320 (30%), Positives = 160/320 (50%), Gaps = 11/320 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ + ++ ++ + L E+LK I+D + + ++I Sbjct: 1 MKVLITNRIPEEIIKKYEENFEVDYHDSLDFLSKEELKTRIKDVEGLVCPLSEKIDSEII 60 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPF-SNTRSVAELVIGELLLLLRGVPE 129 +AA+ L I + G + VD+D A ++GI V NAP ++T+S AEL G ++ LLR + + Sbjct: 61 DAAKNLKIIANYGAGFDNVDIDYAKEKGIIVTNAPASASTKSTAELTFGLMIDLLRNITK 120 Query: 130 ANAKAHRG---VWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL 186 N+ + W + GK LGIIG G IGT++ A++ M V FY+ K Sbjct: 121 MNSDCYDNSFEGWKPVYGLGETLEGKTLGIIGLGRIGTEVMRKAKAFDMNVIFYNRSKKE 180 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + + L+ LL SDV++LH + +++ AK S MK + LINASRG V+ Sbjct: 181 --VDGAKQVDLNYLLENSDVITLHTAYSEKLHHLIDAKAFSKMKKSAYLINASRGKVISE 238 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 L +AL +AG A+DV+ EP + D L N+LL PH+G +T+ A+ +G Sbjct: 239 QDLINALNDGEIAGCALDVYEFEPKISED-----LRNAKNILLAPHLGNATKLARVQMGE 293 Query: 307 EVAGKLIKYSDNGSTLSAVN 326 ++++ + + VN Sbjct: 294 FTFDNIMQFKNGEIPKNKVN 313 >UniRef50_A1RDF9 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=1 Tax=Arthrobacter aurescens TC1 RepID=A1RDF9_ARTAT Length = 329 Score = 349 bits (897), Expect = 1e-94, Method: Composition-based stats. Identities = 100/322 (31%), Positives = 162/322 (50%), Gaps = 11/322 (3%) Query: 13 FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINA 72 + + +H+ L +R ++ + ++ + E+I + LR+ T T ++I A Sbjct: 4 IYISDVIHEDVLADIRKNAIVHVGYGPDKVNYLDISENI---DGVILRAET-FTREMIEA 59 Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA 132 + +L I +GT+ VD+ AA++ + V + P SN+ +VAE V LL L R + A Sbjct: 60 SPRLKIIARHGVGTDNVDIPAASEHSVWVTSTPGSNSNAVAEHVFSLLLSLTRRIIPAAN 119 Query: 133 KAHRGVWN--KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + G W + FE G+ LGI+G+G IG ++ +A GM V D Sbjct: 120 RVLAGTWAEGRGDLVGFELSGRTLGIVGFGAIGKRVATIANGFGMRVLASDPIATAADAE 179 Query: 191 ATQ--VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 A + L L + +D+++LH P T++M+ +E+++MKP +++IN SRG ++D A Sbjct: 180 AAGAVLVELDTLYDGADIITLHAPLLSGTRHMISPRELAMMKPSAIIINTSRGGLIDEDA 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTS---PLCEFDNVLLTPHIGGSTQEAQENIG 305 L AL + LAGAA+DV E DP T PL E N+L+TPHI G TQEA + G Sbjct: 240 LVTALTNGTLAGAALDVLEAESIDMKDPLTHNSVPLHEVPNLLVTPHIAGQTQEAFQEAG 299 Query: 306 LEVAGKLIKYSDNGSTLSAVNF 327 ++ + VN Sbjct: 300 TRSWSEVRAVLAGTTPAFPVNA 321 >UniRef50_D2RN56 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RN56_ACIFE Length = 319 Score = 349 bits (896), Expect = 1e-94, Method: Composition-based stats. Identities = 99/322 (30%), Positives = 150/322 (46%), Gaps = 11/322 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + A E L GY + A D+ L ++I D + R+ T+ V++ Sbjct: 3 KILVPKALKPVAREFLTKKGYELV--SPEATDEASLAKAIADVDAVIARTE-KYTKTVVD 59 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A + L I + IG +DL A + + V A NT SVAE I +L R +P+ N Sbjct: 60 AGKNLKIIARYGIGYENIDLAACDAKNVTVTLARGCNTYSVAEHAISLMLACFRQIPQLN 119 Query: 132 AKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYD--IENKLP 187 + +G W + A + EAR K G IG G IG + +A M + YD ++ Sbjct: 120 QEVRKGNWKSRDAIETHEARYKTFGSIGIGPIGLEAVKIAHFGFQMRILVYDKFVDRSQF 179 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 V L +L+ +DVVS H+P N T +++ + IS MKP ++L+N SRG + D Sbjct: 180 PDWVEFVDTLDELMEQADVVSPHLPLNKGTFHIIDEEAISHMKPTAVLLNVSRGAIWDEK 239 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 A+ AL +A A DVF TEP T PL N + PH T+EA + + + Sbjct: 240 AVYKALKEGRIAAAGADVFETEPPTPDM----PLFSLPNYIGCPHTAALTEEAVDAVAMN 295 Query: 308 VAGKLIKYSDNGSTLSAVNFPE 329 A + + +N PE Sbjct: 296 CAQAIDDLLNGREPKFIINHPE 317 >UniRef50_C7H045 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7H045_9FIRM Length = 388 Score = 349 bits (896), Expect = 1e-94, Method: Composition-based stats. Identities = 106/379 (27%), Positives = 171/379 (45%), Gaps = 32/379 (8%) Query: 47 LKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPF 106 + E +DA + +RS ++ + L I G N + +D K+GI VFNAP Sbjct: 25 VAEDAKDAEGLIVRSYDLHD---MDFDDSLRCIARAGAGVNNIPVDECTKKGIVVFNAPG 81 Query: 107 SNTRSVAELVIGELLLLLRGVPEANAKA----------HRGVWNKLAAGSFEARGKKLGI 156 +N +V ELVI +LL R +PEA + K E RGK LG+ Sbjct: 82 ANANAVKELVIAGMLLAARNIPEALKWVNTLEMTDDVAKKIEKGKGQFAGTELRGKTLGV 141 Query: 157 IGYGHIGTQLGILAESLGMYVYFYDIENKLPLG-----NATQVQHLSDLLNMSDVVSLHV 211 G G IG Q+ AE LGM V YD + V + L D +SLH+ Sbjct: 142 FGLGAIGVQVANAAEKLGMKVIGYDPYMTVNSAVKLTRKIKLVTSIEGALPECDYISLHI 201 Query: 212 PENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPA 271 P TK M+ + +S +K G+ L+N +R ++D AL AL S L D Sbjct: 202 PAIDETKGMVNQEFLSKVKEGATLLNFARDKLIDDDALIYALKSGKLKKYITD------- 254 Query: 272 TNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVS 331 T+ L + V+ PH+G S+ EA+EN +++ Y +NG+ +++VNFP S Sbjct: 255 ----FTTAKLFGKEGVISIPHLGASSAEAEENCATMAVVEMMDYLENGNIVNSVNFPNCS 310 Query: 332 L-PLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVA 390 L R+ I+ N G+L+ + + G+N+ ++ Y +++++ D D Sbjct: 311 LGEKDEAARISIINSNVSGMLSKITGALGDVGINVENLINKSKGDYAYTLLEVKKDVD-- 368 Query: 391 EKALQAMKAIPGTIRARLL 409 + +++ I R++ Sbjct: 369 PEIIKSSLNFDNIISVRVI 387 >UniRef50_C6PA05 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Thermoanaerobacterales RepID=C6PA05_CLOTS Length = 355 Score = 348 bits (895), Expect = 2e-94, Method: Composition-based stats. Identities = 100/324 (30%), Positives = 159/324 (49%), Gaps = 15/324 (4%) Query: 7 EKDKIKFLLV----EGVHQKALESLRAAGYTNIEFHKGA-LDDEQLKESIRDAHFIGLRS 61 K +K L+ E L+ Y I G ++++LKE I+D + + Sbjct: 34 AKMTMKVLITPRSFGKTSNIPFEMLKKYDYEIIRNETGKPYEEDELKELIKDVDGVIV-G 92 Query: 62 RTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELL 121 +TEDV+ A+KL I + +G + +D++ A K GI V P +N SVA+L +L Sbjct: 93 LDKITEDVLKNAKKLKVITKYGVGLDNIDINYAEKLGIKVTYTPGANKESVADLAFTMML 152 Query: 122 LLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD 181 L R + + + WNK+ E GK +GIIG G IG + A M + YD Sbjct: 153 GLSRDIIKLDKIVRNNQWNKII--GCEIYGKTIGIIGTGSIGKCVAKRATGFDMEILAYD 210 Query: 182 IENKLPLGNATQVQHLS--DLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINAS 239 + ++++ LL SD ++LHVP + + +E+++MK + +IN S Sbjct: 211 KYPDYDFADKIGMKYVDKKTLLEKSDFITLHVPLTDEMYHFIDEEELNMMKDTAYIINTS 270 Query: 240 RGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQE 299 RG +++ AL AL SK +AGAA+D F TEP P + L E DN++L+PH G ST++ Sbjct: 271 RGGIINENALYSALKSKKIAGAALDAFETEP-----PLNNKLLELDNIILSPHCGASTKD 325 Query: 300 AQENIGLEVAGKLIKYSDNGSTLS 323 A + +G+ LI + Sbjct: 326 ATDRMGIMAVEGLISVLEGMEPKY 349 >UniRef50_B6G9P0 Putative uncharacterized protein n=3 Tax=Bacteria RepID=B6G9P0_9ACTN Length = 427 Score = 348 bits (894), Expect = 2e-94, Method: Composition-based stats. Identities = 105/380 (27%), Positives = 179/380 (47%), Gaps = 32/380 (8%) Query: 46 QLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAP 105 + E DA I +RS D+ + AIG G N + ++ A+RG+ VFN+P Sbjct: 63 EFVERAEDADAILMRSTDLHGYDLPEG---IRAIGRCGAGVNNIPIEEYARRGVVVFNSP 119 Query: 106 FSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWN----------KLAAGSFEARGKKLG 155 +N+ +V E+V+ +++ RG+ +A + K A E RGK++G Sbjct: 120 GANSNAVKEIVLAMMIMSSRGIVQAMQWVRANADDPDILTSAEKAKKAFVGREIRGKRIG 179 Query: 156 IIGYGHIGTQLGILAESLGMYVYFYDI----ENKLPLGNATQ-VQHLSDLLNMSDVVSLH 210 ++G G++G+++ LGM VY YD E+ L Q V L DL D ++LH Sbjct: 180 VVGLGNVGSKVANACVELGMDVYGYDPFISVEHAWALNREVQRVGTLEDLCRGCDYLTLH 239 Query: 211 VPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEP 270 VP T M+ ++++L+ PG++LIN +R T++D A+ AL + L+ A D Sbjct: 240 VPSKADTVGMISTEQLALLAPGAVLINFARETIIDEDAVAAALEAGKLSWFACD------ 293 Query: 271 ATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEV 330 T +T H G T+EA+ N +L Y +NG+ +VN+P Sbjct: 294 -----FATPKTVRMPRTFITTHSGAGTEEAEANCADMAISELKDYLENGNIAHSVNYPAC 348 Query: 331 SL-PLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDV 389 S+ R+ +H N P ++ + I A+ N+ +++ + Y + D DE + Sbjct: 349 SMGKARAASRIACLHANVPNMIGQITAILAKDNANVQRMVNESAGENAYTMFD--TDEHL 406 Query: 390 AEKALQAMKAIPGTIRARLL 409 ++A+K IP R R++ Sbjct: 407 DRATIEALKQIPSMYRVRVI 426 >UniRef50_Q5WLJ2 D-3-phosphoglycerate dehydrogenase n=7 Tax=Bacteria RepID=Q5WLJ2_BACSK Length = 316 Score = 348 bits (894), Expect = 2e-94, Method: Composition-based stats. Identities = 94/310 (30%), Positives = 142/310 (45%), Gaps = 12/310 (3%) Query: 22 KALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGC 81 + + L+ G + + E+ R A + V+ L I Sbjct: 16 EPIIRLQQEGIELVRVPPDISQSAFVLEA-RGAQAAIVAFNEIHDA-VLAQLPDLKIIAK 73 Query: 82 FCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNK 141 +G + +D+DAA K G+ V N P +N +VA+ LL L R +P N K +G W Sbjct: 74 HGVGVDNIDVDAAKKHGVTVTNVPNANKHAVADFAFSLLLSLARQIPTGNEKTKKGKWP- 132 Query: 142 LAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKLPLGNATQVQHLSD 199 + + + LGIIG G IG ++ A M V YD N + L Sbjct: 133 -SLFGADVYQQTLGIIGLGAIGKEVARRASGFSMTVLAYDPYIDRTYARKNGIEAVSLDA 191 Query: 200 LLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLA 259 LL SD V++H+P P T++++G +E+ LMK + L+NASRG +VD AL +AL ++ LA Sbjct: 192 LLQQSDFVTIHIPLLPETRHLIGERELQLMKKSAYLVNASRGGIVDETALYEALQTQQLA 251 Query: 260 GAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDN- 318 GAA+DVF EP SPL D+ + PH+ G T A + ++I Sbjct: 252 GAALDVFEEEPLH-----MSPLFSLDSFIAMPHVAGYTPGAINTLSHTCVDQIIAVLKGK 306 Query: 319 GSTLSAVNFP 328 G + V+ P Sbjct: 307 GDLIHVVSGP 316 >UniRef50_Q031D4 D-3-phosphoglycerate dehydrogenase n=9 Tax=Streptococcaceae RepID=Q031D4_LACLS Length = 398 Score = 347 bits (892), Expect = 4e-94, Method: Composition-based stats. Identities = 105/373 (28%), Positives = 169/373 (45%), Gaps = 31/373 (8%) Query: 54 AHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVA 113 A R++ + +++L+AIG G N + ++ A +GI VFNAP N +V Sbjct: 34 ADAFICRAQPFHDYEF---SKELLAIGRAGAGFNNIPIEKCASKGIVVFNAPGGNANAVK 90 Query: 114 ELVIGELLLLLRGVPEANAKA--HRGVWN---------KLAAGSFEARGKKLGIIGYGHI 162 ELV+ ++ R + AN +G K A E GK LG+IG G+I Sbjct: 91 ELVLSMMIFGTRNLKPANKWLTGQKGNDKAIDVAVENGKKAFSGSEISGKTLGVIGLGNI 150 Query: 163 GTQLGILAESLGMYVYFYDIENKLPLG-----NATQVQHLSDLLNMSDVVSLHVPENPST 217 G+++ A+ LGM V YD + + +V LS++ +D +++H P T Sbjct: 151 GSKVANDAQRLGMKVIGYDPYLSIEHAWNLSHHVKRVNDLSEIFEKADYITVHTPATDET 210 Query: 218 KNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPF 277 K M+ K +S K G +L+N +R + D A+ A+ + D F +E Sbjct: 211 KGMLNWKNLSKCKNGVILLNYARDEISDKEAILKAIDEGIVRFFGTD-FGSE-------- 261 Query: 278 TSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGG 337 V LTPH+GGST EA N + Y G +++VNFP V L+ Sbjct: 262 --KFYHHPQVFLTPHLGGSTAEASLNCTRMALDSVQTYLKTGEIINSVNFPRVLQELNTP 319 Query: 338 RRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDI-EADEDVAEKALQA 396 R+ I++N P V+ ++ AE+ +NIA + Y ++D+ E DE + Sbjct: 320 YRVTLINKNVPNVVAQISIAVAEENINIANIVNRGQGDFAYTLLDLDEKDERKLAALVSR 379 Query: 397 MKAIPGTIRARLL 409 +A +R RL+ Sbjct: 380 FEASENIVRVRLI 392 >UniRef50_B1R2D5 Glycerate dehydrogenase n=6 Tax=Clostridiales RepID=B1R2D5_CLOBU Length = 314 Score = 347 bits (891), Expect = 4e-94, Method: Composition-based stats. Identities = 109/321 (33%), Positives = 159/321 (49%), Gaps = 14/321 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGY------TNIEFHKGALDDEQLKESIRDAHFIGLRSRTH 64 +K ++E + + + L A + D E L E +DA + L S Sbjct: 1 MKLSILEPLGVEKEKFLNMAEKVLGDRVEITYYDNRVEDSETLIERSKDAEIVVL-SNFQ 59 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 +DVI L I G + VD+D RGI V N +T +VA+LV G L+ + Sbjct: 60 YRKDVIEKCPNLKMICVAFTGVDHVDIDYCKDRGITVCNCAGYSTVAVADLVFGLLINIY 119 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 R + E N +G K FE GKK G+IG G IG ++ +A++ G VY Y Sbjct: 120 RNIVECNIVTRKGG-TKNGLVGFELEGKKFGVIGTGAIGMRVANIAKAFGCEVYAYSRTV 178 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 K G + L+ LL+ DV+SLHVP N +TK ++ + I LMK ++LIN +RG VV Sbjct: 179 KE--GKEIKYVDLNTLLSTCDVISLHVPLNENTKGLINEENIKLMKKSAVLINTARGPVV 236 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL DAL + +AGA IDVF EP P L + N+++TPH+ +T+E+ Sbjct: 237 DSKALSDALKNNIIAGAGIDVFEIEPPI---PVDHVLFDAPNLIVTPHVAFATKESMVKR 293 Query: 305 GLEVAGKLIKYSDNGSTLSAV 325 V + KY NGS+ + + Sbjct: 294 AEIVFDNIDKYI-NGSSQNVI 313 >UniRef50_A0LN07 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=2 Tax=Bacteria RepID=A0LN07_SYNFM Length = 317 Score = 347 bits (891), Expect = 5e-94, Method: Composition-based stats. Identities = 96/320 (30%), Positives = 155/320 (48%), Gaps = 12/320 (3%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K K LL E +H + E L + +LD++ L D I +R+ +T + Sbjct: 4 KFKILLYESMHARGTEVLAEKCELV---YATSLDEKNLIAQAADVDGIIIRANGAVTRAL 60 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I +A +L IG +G + +DL A +RG+ V P +NT SVAE +G ++L + + Sbjct: 61 IESAPRLKVIGRHGVGLDAIDLRCAKERGVKVVFTPTANTESVAEHFVGMAIMLAKMIRT 120 Query: 130 ANAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIENKLP 187 + G W + E GK LG++G+G IG Q + M V +YD+ + Sbjct: 121 GDIALRTGDWAARNRLIGTELHGKALGVLGFGRIGRQTARICRNGFAMNVIYYDVCDYPA 180 Query: 188 LGNATQVQHL--SDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 + Q + + ++ SD +S+++P PST++ + AK I LMKP + LIN +RG V + Sbjct: 181 VEKELQAKRVSGEEVFEQSDFISVNLPLLPSTRHFVNAKLIRLMKPTAFLINMARGPVWN 240 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 + AL K +AG DV+ EP P PL + DN + TPH+ ++EA + Sbjct: 241 EEDVAGALREKRIAGVGSDVYEVEPV----PADHPLLKMDNFVGTPHMSAHSEEAMIRMS 296 Query: 306 LEVAGKLIKYSDNGSTLSAV 325 L VA ++ + V Sbjct: 297 L-VASDVVAVLEGREPEYPV 315 >UniRef50_C0BYY9 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM 15053 RepID=C0BYY9_9CLOT Length = 330 Score = 346 bits (890), Expect = 7e-94, Method: Composition-based stats. Identities = 102/323 (31%), Positives = 154/323 (47%), Gaps = 15/323 (4%) Query: 12 KFLLVE----GVHQKALESLRAAGYTNI--EFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 K L+ + A E L + G+ + E +QL E + + + Sbjct: 9 KILITASHYHELCADARELLESRGHELMINESALPYYTFQQLAEVVGNIDAAVV-GLDEW 67 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 TE+V A +L I F +GT+ +D D A + GI V NAP N+ +VAEL +G ++ LLR Sbjct: 68 TEEVFRMAPRLKVIAKFGVGTDNIDCDTAKEYGIKVINAPGQNSNAVAELTVGFMIQLLR 127 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 + +G W + G E +GK +G+ G+G + + S V D+ Sbjct: 128 NILPLYEGIRQGQWVRYIGG--ELKGKTVGLFGFGAVAKLVAKKLSSFETEVIACDLHPD 185 Query: 186 LPLGNATQV--QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 V +++ SD++S+H+P +T +++ IS MK G+ +IN +RG V Sbjct: 186 SEYAKKYNVGLVSAEEVVERSDILSVHLPATSATYHLVDKAMISKMKRGACMINCARGAV 245 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 VD AL +AL S +LAGAA+D F TEP P S L DNV+ TPH G T EA N Sbjct: 246 VDTEALTEALKSGYLAGAALDAFETEPL----PADSLLLTCDNVICTPHTGAETYEAYRN 301 Query: 304 IGLEVAGKLIKYSDNGSTLSAVN 326 + L A ++ + L VN Sbjct: 302 VSLCTAQGILDVLEGREPLYWVN 324 >UniRef50_B2T8V2 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Burkholderia phytofirmans PsJN RepID=B2T8V2_BURPP Length = 327 Score = 346 bits (889), Expect = 8e-94, Method: Composition-based stats. Identities = 95/321 (29%), Positives = 152/321 (47%), Gaps = 11/321 (3%) Query: 8 KDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 +K + L +H AL L + + +E L++ + DA + +R L + Sbjct: 2 PEKFRVLATSPIHLSALPILEPSCELVVAPDD---SEETLRKFVADADALIVR--VRLPD 56 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 D+ + A +L A +G + + ++ A + I V N P SNT++VAE V+G +L + RG Sbjct: 57 DIFDHAPRLKACVRHGVGLDFIPVERATRADIAVANLPDSNTQAVAEHVVGAILAMARGF 116 Query: 128 PEANAKAHRGVW-NKLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIENK 185 W + E R + +GI+G G IG Q+ GM V D + Sbjct: 117 DRLPRAWRNDGWLVRQTFQGIELRDRTVGIVGLGRIGLQVAAALHHGFGMRVLGCDNGAR 176 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 L + + ++ + SD ++LH P ST++++ A+ +SL KPG+LL+NA+RG ++D Sbjct: 177 EGLPSYVDQTSIENVFSGSDFITLHAPLVKSTRHLVNAELLSLAKPGALLVNAARGGLID 236 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL AL S + AA+DVF EP P P DNVLLTPH+ T E + Sbjct: 237 DDALVAALRSGQIGCAALDVFEPEPL----PPDHPYWSIDNVLLTPHVAAFTSEGLVRMS 292 Query: 306 LEVAGKLIKYSDNGSTLSAVN 326 A +++ VN Sbjct: 293 TGAARAVVEILHGRRPEHLVN 313 >UniRef50_D1W6S1 4-phosphoerythronate dehydrogenase n=4 Tax=Prevotella RepID=D1W6S1_9BACT Length = 329 Score = 346 bits (889), Expect = 9e-94, Method: Composition-based stats. Identities = 88/330 (26%), Positives = 156/330 (47%), Gaps = 19/330 (5%) Query: 7 EKDKIKFLLVE----GVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSR 62 +K + ++++ + + + G + E++ E +DA + + ++ Sbjct: 8 KKQAVNIVVLDGHCANPGDLSWDGFKELGSLTVYER---TKPEEVVERAKDAQIVLV-NK 63 Query: 63 THLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLL 122 + D+I +L IG G N +D+ AA + G+ V N P +T SVA++V + Sbjct: 64 VSMKADIIAQLPQLKYIGVLATGFNHIDVKAAQEHGVTVCNIPSYSTYSVAQMVFASIFT 123 Query: 123 LLRGVPEANAKAHRGVWNKLAAGSF------EARGKKLGIIGYGHIGTQLGILAESLGMY 176 + V + G W+K + + E GK +GI+G G+IG ++ +A GM Sbjct: 124 ITNRVEHYAQQTREGQWSKRSDFCYWDTPLLELAGKTMGIVGLGNIGMKVARIAREFGME 183 Query: 177 VYFYDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLI 236 VY Y +N + L + Q L L ++SD++SLH P + T+ ++ A + MK G++LI Sbjct: 184 VYAYTSKNSVDLPSGIQKTTLDGLFSVSDILSLHCPLSERTRELIKADNLRKMKHGAILI 243 Query: 237 NASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGS 296 N RG +V+ + AL S LA DV +EP + PL + N +TPHI + Sbjct: 244 NTGRGPLVNEADVAAALESGQLAAYGADVMCSEPPAADN----PLLKQPNAFITPHIAWA 299 Query: 297 TQEAQENIGLEVAGKLIKYSDNGSTLSAVN 326 T EA+ + + + + G+ + VN Sbjct: 300 TVEARSRLMNIALNNVRCFLE-GAAQNVVN 328 >UniRef50_C3XIZ9 D-3-phosphoglycerate dehydrogenase n=4 Tax=Campylobacterales RepID=C3XIZ9_9HELI Length = 535 Score = 346 bits (889), Expect = 9e-94, Method: Composition-based stats. Identities = 109/327 (33%), Positives = 177/327 (54%), Gaps = 15/327 (4%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K ++ + +H + L+ L ++E + L ++L + A + RS T + E + Sbjct: 2 KKHIIVCDHIHDEGLKILSTQDDISME-NLAHLPKDELLTHLHKADVLITRSSTGVNEKL 60 Query: 70 INAA----EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 + +A +KL AI +G + VD+DA + RG+ V N P +NT + EL + LL +R Sbjct: 61 LESAYKDSKKLKAIVRAGVGVDNVDIDACSYRGVVVMNVPTANTIAAVELTMTHLLSAIR 120 Query: 126 GVPEANAKAH-RGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE- 183 P A+ + W + E + KKLG+IG+G+IG+++GI A++ M V YD Sbjct: 121 RFPSAHTQLKVERKWKREDWYGIELKDKKLGVIGFGNIGSRVGIRAKAFDMQVIAYDPYI 180 Query: 184 --NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 NK + D+L D++++H P+N T NM+ +KEI+ MK G +LIN +RG Sbjct: 181 NPNKALDLGIEYTTNFDDILA-CDIITIHTPKNKQTTNMITSKEIAKMKDGVILINCARG 239 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 + + L + L SK +A A +DVF +EPATN + L + DN+ +TPHIG +T E+Q Sbjct: 240 GLYNENDLYEGLKSKKIAWAGLDVFDSEPATN-----NKLLDLDNIYVTPHIGANTLESQ 294 Query: 302 ENIGLEVAGKLIKYSDNGSTLSAVNFP 328 E I +E A I + + +A+N P Sbjct: 295 EKIAIEAAHAAISAARGSAFPNALNLP 321 >UniRef50_UPI00016C0F1F D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016C0F1F Length = 387 Score = 346 bits (888), Expect = 1e-93, Method: Composition-based stats. Identities = 119/417 (28%), Positives = 186/417 (44%), Gaps = 49/417 (11%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 L + + K + L+ + AL E I +RS + ++ Sbjct: 2 FNILTLNEISNKGTDKLKNTDFVVT---PDALAPE----------AIMVRSASMHNMEL- 47 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV--- 127 A L+AI GTN + ++ ++GI VFN P +N +V EL + LLL R + Sbjct: 48 --APNLLAISRAGAGTNNIPIEKCTEQGIVVFNTPGANANAVKELTLAGLLLASREIIAG 105 Query: 128 --------PEAN--AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYV 177 EA+ A +G K A E GK L + G G IG + A SLG+ V Sbjct: 106 TTWTQTLAAEADIAAVVEKG---KKAFIGPEISGKTLVVAGLGAIGVLVANAALSLGLKV 162 Query: 178 YFYDIENKLPLG-----NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPG 232 YD + V++L + +D ++LHVP STK M +KPG Sbjct: 163 IGYDPYLSVTSALLINNGVKIVENLDKAIGQADYLTLHVPYQASTKYMFNQAMFEKIKPG 222 Query: 233 SLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPH 292 ++N SRG +VD AL AL +A D FPT + L NV+ PH Sbjct: 223 CRILNFSRGELVDNTALIAALDLGIVAKYVTD-FPT----------AELLNLQNVICIPH 271 Query: 293 IGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLT 352 +G ST E++EN A +L + G ++VNFP P R+ IH+N P ++ Sbjct: 272 LGASTPESEENCAEMAATELAAFLKYGVIKNSVNFPTCESPYINKPRITLIHKNIPKMVG 331 Query: 353 ALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 + I A++ +NI ++ ++ Y V+D+++ D A K + ++ IPG ++ RL+ Sbjct: 332 QVTNILADENLNIDNMINKSRGEIAYTVVDLDSLND-APKIISLLEQIPGMVKVRLI 387 >UniRef50_UPI000038E3F5 glyoxylate reductase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E3F5 Length = 311 Score = 345 bits (887), Expect = 1e-93, Method: Composition-based stats. Identities = 87/316 (27%), Positives = 142/316 (44%), Gaps = 13/316 (4%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + +E + F + L +I A I + + +++I+ Sbjct: 3 KILVTRNIPGNYIEKIENMEIEV--FSGNGNMRDWLLSNIGSADGILITLNEKIDKELID 60 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 +KL I + +G + +D++ A +GI V N P T + A+L+ G ++ R + N Sbjct: 61 HGKKLKVISTYSVGYDHIDVEYAKSKGIIVTNTPEVLTDATADLIFGLMIAAARNIVSGN 120 Query: 132 AKAHRGV----WNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP 187 H+ WN E GK LGIIG G IG + A M + +Y Sbjct: 121 DLIHKNDWKAGWNPTFMLGSEIHGKTLGIIGMGRIGKAIARRASGFDMKIIYYSRHRHDV 180 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + + +LL SD V + + N T + M ++IS MK + LIN +RG +V+ Sbjct: 181 DAD---FASIDELLQQSDFVIIALDLNADTFHFMDYQKISKMKKTAFLINGTRGKIVNEK 237 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 L AL K + GAA+DVF EP N T+P+ F NV++TPH+G +T E ++ + Sbjct: 238 DLVRALNEKIIEGAALDVFEDEPVDN----TNPILSFSNVVVTPHLGSATYETRDKMAET 293 Query: 308 VAGKLIKYSDNGSTLS 323 L+ + L Sbjct: 294 AVTNLVNVLNGKDPLY 309 >UniRef50_Q6F7L0 Glycerate dehydrogenase n=3 Tax=Proteobacteria RepID=Q6F7L0_ACIAD Length = 318 Score = 345 bits (886), Expect = 2e-93, Method: Composition-based stats. Identities = 84/305 (27%), Positives = 147/305 (48%), Gaps = 14/305 (4%) Query: 29 AAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQ 88 A + +++ + + +Q+ ++D + + ++ + + + KL I GTN Sbjct: 22 QACFNDLQLYSAS-TPDQVIPRLKDVQ-VAITNKVVINAEALTRLPKLKLILVSATGTNN 79 Query: 89 VDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSF- 147 VDL AA +GI V N T SVA+ + +L L + + +G W + + F Sbjct: 80 VDLRAAKAQGIVVCNCQGYGTASVAQHTLTLMLALATSLLRYDHAVAQGRWQQASQFCFL 139 Query: 148 -----EARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLLN 202 E GK LGI+GYG +G ++ LA++ GM + ++ + + + L LL Sbjct: 140 DYPIIELSGKTLGIVGYGELGKEVARLAQAFGMKILIANLPQRPKHEDRLE---LEALLP 196 Query: 203 MSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAA 262 D +SLH P T++++ A +LMKP + LIN +RG +V AL DAL +AGAA Sbjct: 197 QVDFLSLHCPLTEHTQHLIDAHAFALMKPSAFLINCARGGIVHEQALLDALKQGRIAGAA 256 Query: 263 IDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTL 322 DV EP N +P + N+++TPH + ++++ + ++A +S + Sbjct: 257 TDVLSIEPPKNGNPLLDE--KLPNLIITPHSAWGSVQSRQRMVEQLAENAKAFSIGQTIR 314 Query: 323 SAVNF 327 VN Sbjct: 315 Q-VNA 318 >UniRef50_Q03YV3 Lactate dehydrogenase related enzyme n=2 Tax=Leuconostoc RepID=Q03YV3_LEUMM Length = 314 Score = 345 bits (886), Expect = 2e-93, Method: Composition-based stats. Identities = 96/315 (30%), Positives = 157/315 (49%), Gaps = 10/315 (3%) Query: 13 FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINA 72 L + + + L AG + D E++K +A + + ++ D+++A Sbjct: 5 VFLPDDIPAVGKKILEEAGLEVV--VGSGRDHEKMKAEGVEASAVLIGTQ-KFDADIMDA 61 Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA 132 L I +G + VD+DAA +RGI V N P + + SVAE + ELL + + + + + Sbjct: 62 MPNLKVIARNGVGYDAVDVDAATQRGIYVVNTPKALSGSVAETAVSELLAISKNLYQDSK 121 Query: 133 KAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 H WN + A + GK +GI+G+G IG Q+ + V +D K G Sbjct: 122 AIHDDNWNYRKAHPGRDIEGKTVGILGFGRIGQQVAKKLSGFDVKVIAFDPFAKDVPG-- 179 Query: 192 TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCD 251 ++ + +D V +H+P P T++ +GA E LMK + LIN +RG+++ L Sbjct: 180 VELVDRETIFKTADYVMVHLPALPETQHSIGADEFKLMKNDAFLINMARGSILVESDLVL 239 Query: 252 ALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGK 311 AL S +AGAA+DVF EP P T+PL +NVLLTPHI +T E + + ++ Sbjct: 240 ALKSGEIAGAALDVFEEEPL----PVTNPLVALENVLLTPHIASNTVETKARMAVDATND 295 Query: 312 LIKYSDNGSTLSAVN 326 +++ + SAVN Sbjct: 296 IVRVLSGKNPESAVN 310 >UniRef50_P0A545 D-3-phosphoglycerate dehydrogenase n=57 Tax=Actinomycetales RepID=SERA_MYCBO Length = 528 Score = 345 bits (885), Expect = 3e-93, Method: Composition-based stats. Identities = 103/317 (32%), Positives = 159/317 (50%), Gaps = 10/317 (3%) Query: 13 FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINA 72 L+ + + + +L G D ++L ++ +A + +RS T + +V+ A Sbjct: 6 VLIADKLAPSTVAAL---GDQVEVRWVDGPDRDKLLAAVPEADALLVRSATTVDAEVLAA 62 Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA 132 A KL + +G + VD+DAA RG+ V NAP SN S AE + LL R +P A+A Sbjct: 63 APKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASRQIPAADA 122 Query: 133 KAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKLPLGN 190 W + + E GK +G++G G IG + + G YV YD Sbjct: 123 SLREHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAAQL 182 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 ++ L DLL +D +S+H+P+ P T ++ + ++ KPG +++NA+RG +VD AL Sbjct: 183 GIELLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALA 242 Query: 251 DALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAG 310 DA+ H+ A +DVF TEP T SPL E V++TPH+G ST EAQ+ G +VA Sbjct: 243 DAITGGHVRAAGLDVFATEPCT-----DSPLFELAQVVVTPHLGASTAEAQDRAGTDVAE 297 Query: 311 KLIKYSDNGSTLSAVNF 327 + AVN Sbjct: 298 SVRLALAGEFVPDAVNV 314 >UniRef50_B6YUM0 D-isomer specific 2-hydroxyacid dehydrogenase n=9 Tax=Thermococcaceae RepID=B6YUM0_THEON Length = 333 Score = 344 bits (884), Expect = 3e-93, Method: Composition-based stats. Identities = 94/326 (28%), Positives = 147/326 (45%), Gaps = 18/326 (5%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 + K L++ + K LE L+ + + E+LKE I + I + + +V Sbjct: 2 RPKVLVLFKIKSKPLEELKKHADVELLLYPSV---EELKEKIGEFDGIIVSPLNPIPREV 58 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I AEKL I C G + VD+ AA +RGI V + +VAE +G ++ LLR + Sbjct: 59 IERAEKLKVISCHSAGYDHVDVKAATERGIYVTKVSGVLSEAVAEFAVGLMIALLRRIVY 118 Query: 130 ANAKAHRGVWN--KLAAGSF----EARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE 183 + G W ++ F GK +GI+G G IG + ++LG V ++ Sbjct: 119 TDRFIRAGKWESHRVIWSGFKDIETVYGKTVGILGMGAIGKAIARRVKALGTEVVYWSRS 178 Query: 184 NKLPLGNAT--QVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 K + + L ++L +D+V L +P P T +++ + + LM G L+N RG Sbjct: 179 RKKDIEEEVNAKYLSLEEVLKSADIVVLALPATPETYHIINEERLKLM-EGKYLVNIGRG 237 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFD-NVLLTPHIGGSTQEA 300 ++VD AL AL L G A DVF EP T L + +LTPH G ++EA Sbjct: 238 SLVDEEALVKALKEGKLKGYATDVFEREPVTE-----HELFGMEWETVLTPHYAGLSREA 292 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVN 326 E++G L+ VN Sbjct: 293 MEDMGFRAVENLLTVLRGEVPGDLVN 318 >UniRef50_B2KCL9 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Elusimicrobium minutum Pei191 RepID=B2KCL9_ELUMP Length = 315 Score = 344 bits (884), Expect = 3e-93, Method: Composition-based stats. Identities = 103/319 (32%), Positives = 163/319 (51%), Gaps = 8/319 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIR--DAHFIGLRSRTHLTED 68 +K L+ + + +E L+ G+ I ALD+ L E+ + A I +RS T + Sbjct: 1 MKILIADKFPKHWVEVLKEKGHEII--LNPALDENTLPEAQKTEQAEIIIVRS-TKVNAS 57 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 I+AA L + G + +D++ A +G+ V N P +N+ +VAEL +G +L L R +P Sbjct: 58 AIDAAPSLKLVIRAGAGYDTIDINHAKTKGVAVCNCPGTNSIAVAELAMGLILSLDRRIP 117 Query: 129 EANAKAHRGVWNKLAAGSFE-ARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP 187 + G WNK + G+ LGIIG GHIG ++ A++ G+ + +D K Sbjct: 118 DNIIDLKAGKWNKTEYSKAKGLYGRTLGIIGLGHIGREVAKRAQAFGLKIIAFDPFVK-E 176 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 A V + DL +D++++HVP TK+ K MKPG+ IN SRG +V Sbjct: 177 SPLAQMVSDVYDLAKKADIITIHVPNTAGTKHFYDEKFFEAMKPGAYFINTSRGGLVKED 236 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL A A K + AA+DV+ EP ++ F P+ N+ T HIG ST++AQ+ + Sbjct: 237 ALIKACAEKGIR-AALDVYEKEPKADAKEFVDPVTSAVNIYGTHHIGASTEQAQDAVAEV 295 Query: 308 VAGKLIKYSDNGSTLSAVN 326 + + +D G+ L VN Sbjct: 296 AVQIVQELADKGTFLHQVN 314 >UniRef50_O33116 D-3-phosphoglycerate dehydrogenase n=22 Tax=Actinomycetales RepID=SERA_MYCLE Length = 528 Score = 344 bits (883), Expect = 4e-93, Method: Composition-based stats. Identities = 103/317 (32%), Positives = 160/317 (50%), Gaps = 10/317 (3%) Query: 13 FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINA 72 L+ + + Q + +L G D +L ++ +A + +RS T + +V+ A Sbjct: 6 VLIADKLAQSTVAAL---GDQVEVRWVDGPDRTKLLAAVPEADALLVRSATTVDAEVLAA 62 Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA 132 A KL + +G + VD+DAA RG+ V NAP SN S AE + LL R + EA+A Sbjct: 63 APKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASRQIAEADA 122 Query: 133 KAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKLPLGN 190 +W + + E GK +G++G G IG + + G +V YD Sbjct: 123 SLRAHIWKRSSFSGTEIFGKTVGVVGLGRIGQLVAARIAAFGAHVIAYDPYVAPARAAQL 182 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 ++ DLL +D +S+H+P+ P T ++ + ++ KPG +++NA+RG +VD AL Sbjct: 183 GIELMSFDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEVALA 242 Query: 251 DALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAG 310 DA+ S H+ A +DVF TEP T SPL E V++TPH+G ST EAQ+ G +VA Sbjct: 243 DAVRSGHVRAAGLDVFATEPCT-----DSPLFELSQVVVTPHLGASTAEAQDRAGTDVAE 297 Query: 311 KLIKYSDNGSTLSAVNF 327 + AVN Sbjct: 298 SVRLALAGEFVPDAVNV 314 >UniRef50_B0P693 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=B0P693_9FIRM Length = 322 Score = 344 bits (883), Expect = 4e-93, Method: Composition-based stats. Identities = 81/328 (24%), Positives = 152/328 (46%), Gaps = 13/328 (3%) Query: 9 DKIKFLLVEGVHQK---ALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 K K ++ + ++ E +R AG ++H ++++ + D + + + Sbjct: 2 KKPKVVISDYYYESIAQEREIIRQAGGELFDYHCA--TEDEVISAAADCDALICQ-FAPI 58 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 T VI A + I + IG + +DL AA ++G+ V N P + V+ I L+ ++ Sbjct: 59 TARVIRAMPRCKVIVRYAIGVDNIDLKAAEEQGVYVCNVPDYSIDEVSNHAIALLMDCVK 118 Query: 126 GVPEANAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI-- 182 + ++ G + + +G LG++G+G I + G+ + YD Sbjct: 119 KLTFLASQVKAGRSSYTVVKPLHRMQGSTLGLMGFGRIPRLVAQKMAGFGLKMIAYDPML 178 Query: 183 ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 + + LL SD +S+H P N ST+++ + LMKP ++L+N +RG Sbjct: 179 DQQAAQELGVTPVSFEQLLMDSDYLSIHCPLNESTRHIFNQEAFRLMKPTAVLVNTARGA 238 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 VVD AL AL+ +A A +DV EP + PL + DN ++TPH ++EA Sbjct: 239 VVDEQALIQALSDGQIAMAGLDVTEQEPVAADN----PLLKLDNAVVTPHAAWYSEEAVA 294 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVNFPEV 330 ++ +VA ++ + + + VN P++ Sbjct: 295 SLQRKVAEEVARVLRGETPQNPVNHPKL 322 >UniRef50_Q8ZXX8 D-3-phosphoglycerate dehydrogenase (SerA) n=1 Tax=Pyrobaculum aerophilum RepID=Q8ZXX8_PYRAE Length = 323 Score = 344 bits (883), Expect = 4e-93, Method: Composition-based stats. Identities = 86/319 (26%), Positives = 153/319 (47%), Gaps = 14/319 (4%) Query: 17 EGVHQKALESLRAAGYTNIEFHKGA------LDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 EG + + L G + H G+ + E L ++ R + + + ++V+ Sbjct: 9 EGFPESMYKKLEEVGRVEVYRHGGSPWSTRGVPKEVLIDAARRCEALVIFIGDVIDKEVL 68 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +A EKL + +G + +D++ A ++G+ V + P+ +VA+L +G L+ + R + Sbjct: 69 DAGEKLKIVSTASVGVDHIDVEYAKRKGVVVAHTPYVLVDAVADLAVGLLIAVTRKIALG 128 Query: 131 NAKAHRGVWNKL--AAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL 188 + G + + + RGK+ GI+G G+IG + ++ + V ++ K + Sbjct: 129 DRLIRSGAADAVWGSLMGVNLRGKRAGIVGLGNIGVAIARRLKAFDIEVAYWSRRRKPEV 188 Query: 189 GNA--TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 A + L LL+ SD + L + P T+ + + +K G+ IN +RG +VD Sbjct: 189 EFALGIEYMELDSLLSSSDFIFLTMALTPETRWFFNRERFAKVKRGAYFINVARGGLVDT 248 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL +AL + LAGAA+DVF EP P L DNV+LTPHIG +T E + + Sbjct: 249 DALIEALEAGVLAGAALDVFDVEPL----PARHKLASMDNVVLTPHIGSATVETRRRMAE 304 Query: 307 EVAGKLIKYSDNGSTLSAV 325 A ++ + G + AV Sbjct: 305 LAAENVVSFFRTGRPIYAV 323 >UniRef50_C0WBB3 D-isomer specific 2-hydroxyacid dehydrogenase n=1 Tax=Acidaminococcus sp. D21 RepID=C0WBB3_9FIRM Length = 318 Score = 343 bits (882), Expect = 5e-93, Method: Composition-based stats. Identities = 102/321 (31%), Positives = 153/321 (47%), Gaps = 11/321 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + + A L GY +E D+E +K++I D + R+ T VI Sbjct: 3 KILIPKALKESARTFLTDKGYELVELQ--GTDEETMKKAISDVDAVIARTE-KYTPAVIK 59 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AA L I + IG ++L+A K+G+ V A NT SVAE I +L LR + + + Sbjct: 60 AARNLKIIARYGIGYENINLEACDKKGVTVTLARGCNTYSVAEHAITLMLAALRQISQLD 119 Query: 132 AKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIE-NKLPL 188 + +G W + + EARGK G IG G IG + +A M + YD ++ Sbjct: 120 REVRKGDWKSRDRVETHEARGKVFGSIGIGPIGMEAVKIAHFGFQMKILVYDKFVDQSKF 179 Query: 189 GNATQVQ-HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + + L DL+ SDVVS H+P N T +++ + IS MK G +L+N SRG + D Sbjct: 180 PDWIEFTNTLDDLMERSDVVSPHLPLNKGTFHILNEESISHMKRGGILLNVSRGAIWDEK 239 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 A+ AL + AA DVF TEP T + PL N + TPH ++EA + + Sbjct: 240 AVYQALQEGRIGAAAGDVFETEPPTPDN----PLFALPNFIGTPHTAALSEEAVTAVAMN 295 Query: 308 VAGKLIKYSDNGSTLSAVNFP 328 A + L +N P Sbjct: 296 CAHAIDDLFSGKEPLYIINHP 316 >UniRef50_A8MCX1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=6 Tax=Thermoproteaceae RepID=A8MCX1_CALMQ Length = 317 Score = 343 bits (882), Expect = 5e-93, Method: Composition-based stats. Identities = 92/308 (29%), Positives = 158/308 (51%), Gaps = 8/308 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ + + ++ + L G +K + E+L + + + + +RSRT +T +VI+ Sbjct: 10 RALITDKIDERLINKLSEMGVAV--DYKPGIQHEELLKIVENYDILVVRSRTKVTREVID 67 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 L I +G + +D+D A KRG+ + N+P + T S AEL + +L++ R + Sbjct: 68 RGASLKIIARAGVGLDNIDVDYALKRGLTIVNSPNAATYSAAELTLSLMLIISRNLHLHL 127 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN--KLPLG 189 G W+K E RGK LG++G+G IG + A++LGM + D+ + + Sbjct: 128 IDVKNGKWSKGLYHGIELRGKTLGVVGFGRIGRAVANYAKALGMRILATDVVDISRYAEE 187 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 V L++LL+ SDVV+LHV N T +M+ + L+K ++++N SRG V+D AL Sbjct: 188 LGASVVSLTELLSRSDVVTLHVALNKETYHMLNDDRLKLIKDNAIIVNTSRGEVIDTKAL 247 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 + L L G +DV EP + L + V++TPHIG T +AQ I E+ Sbjct: 248 LNHLD--RLWGVGLDVLEHEPPRED--WEIKLIQHPKVVVTPHIGAETIDAQGRIVDELV 303 Query: 310 GKLIKYSD 317 + + + Sbjct: 304 FNIQEALE 311 >UniRef50_A3MTB6 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=4 Tax=Archaea RepID=A3MTB6_PYRCJ Length = 334 Score = 343 bits (882), Expect = 6e-93, Method: Composition-based stats. Identities = 99/332 (29%), Positives = 158/332 (47%), Gaps = 13/332 (3%) Query: 10 KIKFLLVEGVHQKALES-----LRAAGYTNIEFHKGALDD---EQLKESIRDAHFIG--L 59 K K +++ + L+ + G E + E++ + DA + Sbjct: 3 KYKIVVLSPAPEALLKMWATPIAQKYGIAIDEVEVVTFFEPNYEEIGRHVADADVVVGDY 62 Query: 60 RSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGE 119 R + + K+ I G + +D++A A+RGIPV N +N SVAE I Sbjct: 63 TFRIKIDASLCEKMSKVRLIQQPSTGYDHIDVEACARRGIPVANIGGANAISVAEHTIML 122 Query: 120 LLLLLRGVPEANAKAHRGVWNKLAAGSF--EARGKKLGIIGYGHIGTQLGILAESLGMYV 177 L+LL+ A+ + G W + + E GK G++G G IG ++ + A +LG V Sbjct: 123 ALMLLKRAVYAHRRLLEGQWTQGELMNVIGEVFGKTWGVLGMGRIGREVAVRAMALGAKV 182 Query: 178 YFYDIENKLPLG-NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLI 236 +YD+ + + + + LL SD++S+HVP P+T+ M+G +E+ LMKP +++I Sbjct: 183 IYYDVVRNEEMEKRGAEYRPFNRLLAESDILSIHVPLTPATRKMIGERELRLMKPTAVVI 242 Query: 237 NASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGS 296 N SRG +VD AL A+ +AGA +DVF EP P E NV++TPHI G+ Sbjct: 243 NVSRGEIVDEEALAKAVREGWIAGAGVDVFSVEPPPPDHPLIQAAREGYNVVVTPHIAGA 302 Query: 297 TQEAQENIGLEVAGKLIKYSDNGSTLSAVNFP 328 T EA+ I + K + VN P Sbjct: 303 TNEARMRIINVSLENVFKVLAGLKPDNVVNMP 334 >UniRef50_A4RX85 Predicted protein n=8 Tax=cellular organisms RepID=A4RX85_OSTLU Length = 454 Score = 343 bits (881), Expect = 7e-93, Method: Composition-based stats. Identities = 115/418 (27%), Positives = 181/418 (43%), Gaps = 49/418 (11%) Query: 19 VHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVA 78 + L Y + DD++L D + LRS +V + + Sbjct: 37 ISPVGLNKFPKGKYAV------SGDDKELP---GDPMAMMLRSHKLQVSEVPST---VRG 84 Query: 79 IGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKA---- 134 I GTN + + ++ GIPVFN P +N +V ELV+ LLL RG+ E N Sbjct: 85 IVRCGAGTNNIPVKEMSELGIPVFNTPGANANAVKELVVCSLLLASRGIIEGNKHVNDVI 144 Query: 135 ---HRGVW---------NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI 182 G + +K G E GK LG+IG G IG+++ A LGM V YD Sbjct: 145 NVEENGDYAKISVRIEKDKAMFGGTEIEGKTLGVIGLGAIGSRVVNAALGLGMNVIGYDP 204 Query: 183 ------ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPS-TKNMMGAKEISLMKPGSLL 235 +LP ++ L +L ++D +++HVP T +++ AK ++ KPG L Sbjct: 205 VLSLEAAWRLPGDKMSRADDLDELFALADYITIHVPYIKGVTHHLIDAKSLAKCKPGVNL 264 Query: 236 INASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGG 295 +N +RG ++D A+ + L G SD L ++ PH+G Sbjct: 265 LNFARGEIIDGSAVRAGYDAGKLTG----------KYVSDFSDPDLMGHPRHIVLPHLGA 314 Query: 296 STQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLH---GGRRLMHIHENRPGVLT 352 ST+EA+EN A ++ + + G+ ++VNFP LP H G RL +++N G L Sbjct: 315 STEEAEENSAAMAADTMMDFLETGTIRNSVNFPTTILPPHKNSSGARLCIVNKNESGALG 374 Query: 353 ALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAM-KAIPGTIRARLL 409 + Q NI Q + + Y VID+E + ++ A P I +R + Sbjct: 375 EITTFLGTQNCNILQQINTSRDSVAYTVIDLETCPEDPGALQDSLAAACPMVISSRFI 432 >UniRef50_D1CGN8 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CGN8_THET1 Length = 319 Score = 343 bits (881), Expect = 7e-93, Method: Composition-based stats. Identities = 108/309 (34%), Positives = 151/309 (48%), Gaps = 13/309 (4%) Query: 20 HQKALESLRAAGYTNIEFHKG-ALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVA 78 + L AG + G A +E+L E + + I + LT VI AA +L Sbjct: 20 DPSHIRQLEEAGCEVVPNSLGRAYREEELLELLPEMDAI-ITGTDELTARVIEAAGRLRT 78 Query: 79 IGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGV 138 I +G + +DL+AA +RGI V P + SVA+L +G ++ + R + A+ G Sbjct: 79 IAKHGVGLDNIDLEAARRRGIVVTATPGAIHDSVADLTMGLIIAVARQIVPAHNSTVAGE 138 Query: 139 WNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IENKLPLGNATQVQH 196 W E R K LGIIG G IG + + A GM V YD + + + + Sbjct: 139 WR--NFVGLELRDKTLGIIGLGRIGKGVCLRALPFGMRVVAYDLYPDEEFARAHGVRFVG 196 Query: 197 LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASK 256 L +LL SDVV+LH + ++G +EI LMKPG++ IN SRG +VD ALC+ALA Sbjct: 197 LEELLATSDVVTLHASAGNDGR-LLGRREIGLMKPGAIFINTSRGKLVDEGALCEALAVG 255 Query: 257 HLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYS 316 LAGA +DVF EP PL E NV+LTPHI G T+E +G ++ Sbjct: 256 RLAGAGLDVFEEEPPRG------PLLELPNVVLTPHIAGQTREGMIRMGEMTVQNCLRAL 309 Query: 317 DNGSTLSAV 325 L V Sbjct: 310 RGEEPLYRV 318 >UniRef50_UPI0001973600 D-3-phosphoglycerate dehydrogenase n=1 Tax=Clostridium sp. M62/1 RepID=UPI0001973600 Length = 314 Score = 342 bits (879), Expect = 1e-92, Method: Composition-based stats. Identities = 104/313 (33%), Positives = 166/313 (53%), Gaps = 8/313 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+++ V+ E L H + EQ+ I D + +R + +D++ Sbjct: 1 MKCLIIDKVYAGIAEELGKFMEVKTAEHLPS-SKEQVLAEIGDVDVLIMRVDPKIDKDIL 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA+ L IG +G N +D++ A ++GI +FNAP N +VAEL I ++L + RG A Sbjct: 60 GAAKNLKIIGVCSVGLNHIDMEYAKEKGIQIFNAPGLNANAVAELTISKMLDISRGTMTA 119 Query: 131 NAKAH-RGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 N + W+K E RGK LG++G+G IG ++G L + GM V YD K Sbjct: 120 NYDVKVKHEWDKYKFVGRELRGKTLGVMGFGRIGRRVGELGRAFGMTVVAYDPFLKPEDF 179 Query: 190 NATQVQHL--SDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + +LL +SD VS+HVP P TK++ AK I+ MK ++++N SRG +V+ Sbjct: 180 EKEHATGMGIDELLKVSDFVSIHVPLTPETKDLFNAKSIAEMKDDAVVLNMSRGGIVNEK 239 Query: 248 ALCDALASKHLAGAAIDVFPTEP----ATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 + +AL + + G A DV E T +D F SPL E DN +++PHIG + +A ++ Sbjct: 240 DMYEALKAGKIGGYATDVMENELAGSGLTGNDTFASPLFECDNFIVSPHIGAQSVDASKD 299 Query: 304 IGLEVAGKLIKYS 316 IG+ + K+ + Sbjct: 300 IGIHIIAKVKEAL 312 >UniRef50_B3T034 Putative D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein n=1 Tax=uncultured marine microorganism HF4000_001L24 RepID=B3T034_9ZZZZ Length = 311 Score = 342 bits (878), Expect = 1e-92, Method: Composition-based stats. Identities = 90/317 (28%), Positives = 157/317 (49%), Gaps = 9/317 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K L+ + + + A + + K L +E++ + I D + +RS T +T+++I Sbjct: 2 PKVLISDSMSKVAQKIFEKNKISV--DVKTGLSEEEIIKIIPDYDGMVVRSATKVTKNII 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA+KL I G + +D+ A + + V N P N + AE + ++ +LR +P A Sbjct: 60 LAAKKLKVIARAGAGVDNIDVPTAKENNMLVMNTPGGNANATAEHALALIMSVLRKIPYA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY--DIENKLPL 188 N H+G W K E K LGI+G+G++G +L L + + + +E++ Sbjct: 120 NDTTHKGKWEKKNIKGAELSKKTLGIVGFGNVGARLSNLVKGFEVNILVSSKSLESRQKD 179 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + +L++ SD++S H P K ++ + MKP + +IN +RG +VD Sbjct: 180 FPHVKNVSFDELISASDIISFHCKSAPDGKPIINKEHYKKMKPSTFIINTARGNIVDEKD 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L AL +AGAA+DV+ EPA + F +P V+LTPH+ ST EA + Sbjct: 240 LNAALNGNLIAGAALDVYSKEPAKENILFNNP-----KVILTPHVAASTAEASIVVAEMA 294 Query: 309 AGKLIKYSDNGSTLSAV 325 A ++ + G+ ++AV Sbjct: 295 ANQISNFLLKGNKINAV 311 >UniRef50_B9XQY4 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=bacterium Ellin514 RepID=B9XQY4_9BACT Length = 334 Score = 342 bits (878), Expect = 2e-92, Method: Composition-based stats. Identities = 96/323 (29%), Positives = 157/323 (48%), Gaps = 15/323 (4%) Query: 12 KFLLV----EGVHQKALESLRAAGYTNIEFH-KGALDDEQLKESIRDAHFIGLRSRTHLT 66 K ++ E V Q A+ L+AAG + G+ E + + I+DA + + + Sbjct: 4 KVVITAPPIEKVGQNAVALLKAAGCEVVNSAILGSPGSEDVLKIIKDADAV-IAGVEKYS 62 Query: 67 EDVIN--AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 DV + ++L I + +G + +D+ +A + GI + P SVA+ +G LL L+ Sbjct: 63 ADVFSVPETKRLKLISRWGVGFDAIDVTSATREGILITYTPGMTDESVADYTMGLLLALV 122 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 R + + +G+W A + GK LGI+GYG IG + A+ G+ + +D Sbjct: 123 RRIIDGYETMSKGLWQ--PAWGHDMNGKTLGILGYGRIGQAVARRAKGFGLELIAHDPHP 180 Query: 185 KLPLGN-ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 + TQ ++LL SD +SLH ST++++G ++ MKP + LINA+RG + Sbjct: 181 PMGTDQFGTQFVSFNELLERSDYLSLHATLTSSTRDLIGEAQLQKMKPSAYLINAARGPL 240 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 V+ AL AL +AGAA+D F EP P P N+LL+PH S++E+ E Sbjct: 241 VNEQALIRALNEGWIAGAALDAFTVEPL----PVDHPFRRTPNLLLSPHQASSSRESGEL 296 Query: 304 IGLEVAGKLIKYSDNGSTLSAVN 326 I L A ++ +N Sbjct: 297 ISLATAQAVLDLMAGKKPKMPLN 319 >UniRef50_C5BMJ8 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain protein n=10 Tax=Bacteria RepID=C5BMJ8_TERTT Length = 393 Score = 342 bits (878), Expect = 2e-92, Method: Composition-based stats. Identities = 118/382 (30%), Positives = 186/382 (48%), Gaps = 35/382 (9%) Query: 47 LKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPF 106 + E + I LRS E + + ++A+ GTN V +D K G+ VFN P Sbjct: 25 VAEDVSSPEAILLRSHKLHGETLPES---VIAVARAGAGTNNVPVDEYTKSGVVVFNTPG 81 Query: 107 SNTRSVAELVIGELLLLLRGVPEANAKA-------HRGV------WNKLAAGSFEARGKK 153 +N +V ELV+ +LL RG+ + +G K E GKK Sbjct: 82 ANANAVKELVLAGMLLSSRGILQGRDYVATLGDMTDKGEMSKLLEAEKKRFAGSELAGKK 141 Query: 154 LGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG-----NATQVQHLSDLLNMSDVVS 208 LGI+G G IG+ + A +LGM VY +D + + +++ L LL+ D ++ Sbjct: 142 LGIVGLGAIGSMVANAALALGMDVYGFDPALSVEAAWRLPSDVHRMESLQALLSEIDYLT 201 Query: 209 LHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPT 268 LHVP +TKNM+ + MKP + ++N +R +VD A+ +AL + L D FP Sbjct: 202 LHVPAIDATKNMINRDTLGFMKPSAAIMNFARDAIVDSEAVVEALDAGKLRNYVCD-FP- 259 Query: 269 EPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFP 328 EP L + V+ PHIG ST EA+EN + +L Y +NG+ ++VNFP Sbjct: 260 EPC---------LIGHEKVIAVPHIGASTAEAEENCAVMAVNQLRDYLENGNIKNSVNFP 310 Query: 329 EVSL-PLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADE 387 E S+ L G R+ ++N GVL + +FAE VN+ ++ + Y ++DI D Sbjct: 311 ETSMGGLVSGCRITFTNQNVSGVLGNVLSVFAENNVNVIDMMNKSRNDVAYNILDI--DT 368 Query: 388 DVAEKALQAMKAIPGTIRARLL 409 ++ L A+K++ I R++ Sbjct: 369 CPSDAVLAALKSVEHVISLRVI 390 >UniRef50_B1ZP48 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=4 Tax=Verrucomicrobia RepID=B1ZP48_OPITP Length = 326 Score = 341 bits (877), Expect = 2e-92, Method: Composition-based stats. Identities = 85/310 (27%), Positives = 133/310 (42%), Gaps = 13/310 (4%) Query: 25 ESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAA-EKLVAIGCFC 83 + L G+ I +G L++ + + +T V+ A +L + + Sbjct: 20 DLLAQTGWEVIR-ARGPLNEADTLALVGEVDGYIC-GDDAITRQVLEKARPRLKVLSKYG 77 Query: 84 IGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLA 143 IG +++D+ + + GIP+ P N +VAE LL L + G W + Sbjct: 78 IGVDKIDVKSCTEFGIPLLFTPGVNHTTVAEHTFLLLLALEKNFLFHTDSTRSGGWKRKT 137 Query: 144 AGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG---NATQVQHLSDL 200 E K +GI+G G IG ++ I A++ GM YD+ +V L ++ Sbjct: 138 --GHELLEKTIGIVGLGRIGKEVAIRAKAFGMTPIGYDVYWDDKFAAEHGVKRVNSLDEI 195 Query: 201 LNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAG 260 SD +SLH P T+ M+ A + MK G L++N +RG +V+ + AL S + G Sbjct: 196 FAASDYLSLHTNLTPQTRGMINAAAFAKMKKGVLILNCARGEIVNTADMVAALKSGQVGG 255 Query: 261 AAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGS 320 DV EP PL + NV+ TPHIG T E+ LI+ Sbjct: 256 YGTDVLDQEPPAAD----HPLLKLPNVVCTPHIGSRTYESVVRQATAAVTNLIRAMHGEK 311 Query: 321 TLSAVNFPEV 330 L+ VN PEV Sbjct: 312 PLAQVN-PEV 320 >UniRef50_A6ULR7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Sinorhizobium medicae WSM419 RepID=A6ULR7_SINMW Length = 328 Score = 341 bits (877), Expect = 2e-92, Method: Composition-based stats. Identities = 102/314 (32%), Positives = 159/314 (50%), Gaps = 10/314 (3%) Query: 11 IKFLLVEG-VHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTH-LTED 68 K L+ + L L AG +G + +L ES+R F + SRT L Sbjct: 3 PKVLMTAKTLATPGLALLEQAGCAVSFLKEG--TEAELAESLRSTPFDAVISRTLALPAM 60 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 +I A L I +G N VD+++A +RG+PV A +N +SVAEL +G L + R + Sbjct: 61 MIETAPALRVISRHGVGYNNVDIESATRRGVPVLIADGANGKSVAELAVGLALSVARKIT 120 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL 188 +A WN+ A + GK GI+ +G IG ++ + ++ M + +D + Sbjct: 121 TQDASIRARQWNRSAY-GLQFAGKTAGIVAFGAIGRRVAEILRAMDMRIIAFDPHARDRS 179 Query: 189 GNATQV-QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + L +LL SD+VSLH P P T+NM+ A ++ MKPG++LIN +RG ++D Sbjct: 180 TTGVDWTETLDELLQESDLVSLHCPLTPETRNMITAPRLARMKPGAILINTARGGLIDEK 239 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL +A+ S HLAGA +D F EP P P +++TPH+GGST A + + + Sbjct: 240 ALAEAVLSGHLAGAGLDTFADEPL----PADHPFLSLPQIVMTPHMGGSTDVALDGVAIS 295 Query: 308 VAGKLIKYSDNGST 321 A ++ +G Sbjct: 296 AARNVLDVLIDGKV 309 >UniRef50_B0K1J9 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=16 Tax=Bacteria RepID=B0K1J9_THEPX Length = 320 Score = 341 bits (875), Expect = 3e-92, Method: Composition-based stats. Identities = 96/321 (29%), Positives = 157/321 (48%), Gaps = 15/321 (4%) Query: 10 KIKFLLV----EGVHQKALESLRAAGYTNIEFHKG-ALDDEQLKESIRDAHFIGLRSRTH 64 + K L+ E L+ Y I+ G ++ QL + I+D I + Sbjct: 2 RKKILITPRSFGKSSNLPFEMLKKYDYEIIKNESGQPYEESQLIDLIKDVDGIIV-GLDK 60 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 +T +V+ A+KL I + +G + +D+D A + GI + P +N SVA+LV +L L Sbjct: 61 ITSNVLRNAKKLKVITKYGVGVDNIDVDEAERMGIKITYTPDANKESVADLVFALMLGLS 120 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 R + + + W K+ E K +GIIG G IG + A M + YD Sbjct: 121 REIIKLDNIVRNNRWEKII--GNEIYKKTIGIIGTGAIGRCVAKRATGFDMKILAYDKYP 178 Query: 185 KLPLGNATQVQHLS--DLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 N+ ++++ LL SD ++LH+P T + + +E+ +MK + +IN SRG Sbjct: 179 NYEFANSIGMKYVDKKALLEESDFITLHLPLTEETYHFIDEEELKIMKDTAYIINTSRGG 238 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 +++ AL +AL +K +AGAA+DVF EP P S L + DN++LTPH G ST++A + Sbjct: 239 IINENALYNALKNKKIAGAALDVFEIEP-----PIDSKLLKLDNIILTPHCGASTKDATD 293 Query: 303 NIGLEVAGKLIKYSDNGSTLS 323 +G+ LI + Sbjct: 294 RMGIMAVEGLISVLEGMEPKY 314 >UniRef50_Q03W66 D-3-phosphoglycerate dehydrogenase n=3 Tax=Leuconostoc RepID=Q03W66_LEUMM Length = 392 Score = 341 bits (875), Expect = 3e-92, Method: Composition-based stats. Identities = 112/404 (27%), Positives = 179/404 (44%), Gaps = 43/404 (10%) Query: 19 VHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVA 78 + K L+ L+ Y I LRS+ E + + + A Sbjct: 10 ISSKGLDYLKDHHYDINGNDAPK--------------GILLRSQNLHDEPIDD---NVRA 52 Query: 79 IGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP---EANAKAH 135 I G N + ++ +KRGI +FN P N +V EL I L+L R V + Sbjct: 53 IVRAGAGFNNIPVEELSKRGIAIFNTPGGNANAVKELTIASLVLAARPVVGAIQFANDTR 112 Query: 136 RG------VWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 G NK E GKKLG+IG G++G+++ A +L M V YD Sbjct: 113 GGDVSLRTESNKGGYRGTELAGKKLGVIGLGNVGSKVANTALALDMDVIGYDPGLNANTA 172 Query: 190 -----NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + + + ++L +D V++H+P + + A ++ LMKP + L+N SRG +V Sbjct: 173 WRVDRHIVHARSVEEVLEQADYVTVHIPLEEKNRYFIDADKLHLMKPTAALLNLSRGGIV 232 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D A +AL + L D S L + V++TPHIGGST EA++ Sbjct: 233 DDEAAKEALDNDQLRVYITD-----------FADSVLFDNPKVIITPHIGGSTIEAEDTS 281 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVN 364 L A +L +Y G+ +++VN+P+++ P R+ IHEN P +L ++K F + +N Sbjct: 282 ALMAARQLDEYLTTGNIVNSVNYPDINEPFTTKYRVGIIHENVPNMLGQISKFFGDHNIN 341 Query: 365 IAAQYLQTSAQMGYVVIDI-EADEDVAEKALQAMKAIPGTIRAR 407 I + Y ++ I + E+ E A+ IP I R Sbjct: 342 IEQLSNRAVGNYAYTMVAINDFTEEQQELVKTALDEIPHVILTR 385 >UniRef50_C6MGD3 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Nitrosomonas sp. AL212 RepID=C6MGD3_9PROT Length = 324 Score = 341 bits (875), Expect = 4e-92, Method: Composition-based stats. Identities = 90/285 (31%), Positives = 145/285 (50%), Gaps = 14/285 (4%) Query: 43 DDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVF 102 + ++ E IRDA I + ++ + I AA+ L I G N VDL AA++R IPV Sbjct: 35 SESEVPERIRDAEVI-VSNKVFIGRAAITAAKNLKLICVAATGYNNVDLAAASERSIPVC 93 Query: 103 NAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGS------FEARGKKLGI 156 N T SV + V +L L + A RG W E GK LGI Sbjct: 94 NVRGYATPSVVQHVFMLMLNLACHFVDYQALVKRGGWQTSQFFCPLDFGIRELCGKTLGI 153 Query: 157 IGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPS 216 IGYG +G + +A++ GM V + +NKLP +L +D ++LH P + Sbjct: 154 IGYGELGHAVANVAQAFGMQVQIAEHKNKLPRPGRVL---FDAVLQQADFITLHCPLSRE 210 Query: 217 TKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDP 276 T++++ KE LM+P + LIN +RG +V+ L ++L+ +AGAAIDV EP + +P Sbjct: 211 TQHLISRKEFELMQPSAYLINTARGGLVNEADLLESLSLGRIAGAAIDVIQEEPPSKDNP 270 Query: 277 FTSPLCEFD-NVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGS 320 L + N+++TPHI +++E+++ + +A + + + S Sbjct: 271 I---LRQQPANLIVTPHIAWASRESRQRLLELLADNIRNFFQHKS 312 >UniRef50_B0PHF7 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PHF7_9FIRM Length = 319 Score = 340 bits (874), Expect = 5e-92, Method: Composition-based stats. Identities = 98/322 (30%), Positives = 153/322 (47%), Gaps = 15/322 (4%) Query: 13 FLLV----EGVHQKALESLRAAGYTNI--EFHKGALDDEQLKESIRDAHFIGLRSRTHLT 66 L+ + QKA+ L + G+ I + E+L + + Sbjct: 4 ILITASHFRTLCQKAIHLLESNGHQVILNDHELPYYSFEELAVWAPEIDGAII-GMDQWN 62 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 E V A KL + F +G + +DL+AA + G+ V NA N +VAEL + +L LRG Sbjct: 63 EQVFQIAPKLKILARFGVGVDNIDLEAAKRHGVQVVNAAGMNANAVAELAVAMILNCLRG 122 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL 186 +PE N K G W++ A + GK +G++G+G IG ++ + + YD Sbjct: 123 IPELNRKLTDGQWSR--AVGRDLLGKTVGLLGFGDIGGRVAKKLSGFEVRLLAYDPYPNR 180 Query: 187 PLGNATQVQ--HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 A V L +L SD++S+H+P P+T+++M + + MKP S IN +RG +V Sbjct: 181 EKAAALGVTLTDLDTVLTQSDILSIHMPSIPATRHVMNRETFAKMKPDSYFINTARGALV 240 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL DA+A HLAGAA+DV+ EP P +P+ + PH G T+E NI Sbjct: 241 DTQALVDAVAGGHLAGAAVDVYEQEPL----PMGAPILHTPGIQCIPHAGAETRETYSNI 296 Query: 305 GLEVAGKLIKYSDNGSTLSAVN 326 + A +I + +N Sbjct: 297 SMMTAQAVIDSLSGKEPKNWLN 318 >UniRef50_A8MD25 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8MD25_CALMQ Length = 326 Score = 340 bits (874), Expect = 5e-92, Method: Composition-based stats. Identities = 95/317 (29%), Positives = 153/317 (48%), Gaps = 19/317 (5%) Query: 25 ESLRAAGY-TNIEFHKG--------ALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEK 75 ++LR AG+ + +KG A + L+++ + + + + V++ A K Sbjct: 14 DTLRNAGFDLEVWDNKGHGMWDRAAAPPRDVLRDAASRCDALVVTIGDRVDDYVLSNA-K 72 Query: 76 LVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAH 135 + I + +G + +DLDAA +RGIPV P +VA+L IG ++ L R V E + Sbjct: 73 VKVIATYSVGYDHIDLDAATRRGIPVGYTPEVLVEAVADLAIGLIITLARRVIEGDRLVR 132 Query: 136 RGVWNKL--AAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL--PLGNA 191 G K+ E GK LGI+G G+IG + A++ M V ++ K + Sbjct: 133 SGEAYKVWGEFLGTEVWGKTLGILGLGNIGAAVARRAKAFNMNVIYWSRTRKPWIEVALG 192 Query: 192 TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCD 251 + L++L SD + L V + T +++ + + LMK S L+N +RG VVD AL Sbjct: 193 LRYVDLNELFRQSDYLVLTVALSKETYHIVNEERLRLMKNTSYLVNVARGAVVDTNALVK 252 Query: 252 ALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGK 311 AL +AGAA+DV+ EP P T L + +NV+LTPHI +T E + + A Sbjct: 253 ALKEGWIAGAALDVYEEEPI----PNTHELIKLNNVILTPHIASATVETRNKMAEVTALN 308 Query: 312 LIKY-SDNGSTLSAVNF 327 +I N + N Sbjct: 309 VINVLLKNTKPVYQANM 325 >UniRef50_Q214B1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Rhodopseudomonas palustris BisB18 RepID=Q214B1_RHOPB Length = 336 Score = 340 bits (874), Expect = 5e-92, Method: Composition-based stats. Identities = 96/317 (30%), Positives = 150/317 (47%), Gaps = 10/317 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + LL + + + E L + GY + +D++ + I + I +R + ++ V + Sbjct: 24 RILLPQELMPEGREYLESRGYQLV--TGSGMDEDHVIHDIPECDGIIVR-LSPMSARVFD 80 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AA+KL + G + VDL AA K G+ V NAP +N+ SVAEL + +L R Sbjct: 81 AAKKLKVLVRHGSGYDTVDLAAAKKHGVTVLNAPLANSTSVAELALFYMLHCSRNFRLVQ 140 Query: 132 AKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP--L 188 + KL E KKLG+IG G+IG+++ +A M V +D Sbjct: 141 QTMLVDYYKAKLDTPKSEIACKKLGLIGVGNIGSRVAKMARGFDMQVIGFDPYKTQADMP 200 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 Q + D VSLH P P TK + A+++ LMK ++LIN +RGT+V+ Sbjct: 201 EGVELTQDFDRIFTDCDFVSLHCPSTPETKGFVNARQLGLMKGSAVLINTARGTIVNEDD 260 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L AL ++ +AGAA+DV EP + + DNV++ PHIG +T+EA L Sbjct: 261 LYGALTNRKIAGAALDVLAVEPFKPD----HRMLKLDNVVVAPHIGAATREATHRASLHS 316 Query: 309 AGKLIKYSDNGSTLSAV 325 A + + V Sbjct: 317 AIGIHEVLSGQKPSWPV 333 >UniRef50_C0C1A5 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM 15053 RepID=C0C1A5_9CLOT Length = 345 Score = 340 bits (873), Expect = 6e-92, Method: Composition-based stats. Identities = 103/345 (29%), Positives = 160/345 (46%), Gaps = 36/345 (10%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHK---GALDDEQLKESIRDAHFIGLRSRTHLTE 67 +K +++ L+ L G + + +E+L E RDA I + S +T Sbjct: 1 MKIFFTAEYNEEELKPLYEVGEVVKDGWALGLPKMPEEELAEKTRDADMI-ITSYDDITR 59 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 VI AE L I C VD+ AA +RGIPV P N+ S AE+ IG +L R + Sbjct: 60 KVIENAEHLKLIACTRATPVNVDMAAAKERGIPVLYTPGRNSDSTAEMTIGLMLSAARKI 119 Query: 128 PEANAKAHRGV--------------------WNKLA------AGSFEARGKKLGIIGYGH 161 P A G W+ A + +GK LGI+GYG Sbjct: 120 PMAYKALKGGEYTGDPSSRKETKEGLKADVIWDMKADAPYMVFKGTQLKGKTLGILGYGS 179 Query: 162 IGTQLGILAESLGMYVYFYDI---ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTK 218 IG ++G +A + GM + +D E + + + +L+ SD ++ H+ P T Sbjct: 180 IGRRVGRIARAFGMQLLIFDPFVGEVDVEEIGIKKAHSVEELMKESDFITCHMKVTPETT 239 Query: 219 NMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFT 278 ++ + I+LMKP + INASRG ++D AL +AL K +AGAA DV+ +EP P+ Sbjct: 240 GIISRERIALMKPTAYFINASRGAILDEEALIEALKEKRIAGAAFDVYESEPIARDHPYI 299 Query: 279 SPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLS 323 + L DNV++TPHI G+T + N ++ + ++ L Sbjct: 300 TEL---DNVVVTPHIAGATDDVLVNHTKQIVSDIKRFLKGEHLLY 341 >UniRef50_Q6MN05 Phosphoglycerate dehydrogenase n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MN05_BDEBA Length = 328 Score = 340 bits (873), Expect = 6e-92, Method: Composition-based stats. Identities = 94/314 (29%), Positives = 159/314 (50%), Gaps = 8/314 (2%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K K L+ + Q + L+ ++ E + E + AH + +RSRT + E++ Sbjct: 2 KKKILITDRFAQDSFLYLQQ--HSQFEVVRSDNPQHLPLEHLVSAHALIIRSRTKIDEEL 59 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 + A +L I G + +DL+A K G+ V + P +N S A+L G +L + + Sbjct: 60 LKKARQLQLIVTCTSGFDHIDLEATQKWGVTVMHTPTANIESAAQLTWGLVLSCVNNIQA 119 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 A+ G WN+ E G+ GI+G G IG+++ LA++ GM V YD + + Sbjct: 120 AHKMVKAGEWNRDQITGIELAGRNYGIVGLGRIGSRVAELAQAFGMNVVAYDPYQEDEVF 179 Query: 190 NATQVQHL--SDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + L ++L +DV+S HVP+ T++M+ + + G +LIN SRG+V++ Sbjct: 180 ERLHIPRLSYEEVLKTADVISFHVPKTLETEHMLNRSQFEYIHRGIVLINTSRGSVINEN 239 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 LC+AL L +DV+ EP + S L ++ N++LTPHIG +T++A Sbjct: 240 DLCEALEKGWLRSVGLDVYEKEPLNRN----SNLLKYPNLVLTPHIGANTEDAFFKASQI 295 Query: 308 VAGKLIKYSDNGST 321 A KL+ + +GST Sbjct: 296 AANKLMAFFVDGST 309 >UniRef50_A1R7L8 D-3-phosphoglycerate dehydrogenase n=35 Tax=Actinobacteria (class) RepID=A1R7L8_ARTAT Length = 539 Score = 339 bits (871), Expect = 1e-91, Method: Composition-based stats. Identities = 120/378 (31%), Positives = 176/378 (46%), Gaps = 17/378 (4%) Query: 9 DKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 K LL E + +E+L G D QL +I D I +RS T + + Sbjct: 12 SKPVVLLAEELSPATVEAL---GPDFEIRQTDGADRSQLLSAIADVDAILVRSATQVDAE 68 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 I AA+ L I +G + VD+ +A + G+ V NAP SN S AEL +G +L L R +P Sbjct: 69 AIAAAKNLKVIARAGVGLDNVDIKSATQAGVMVVNAPTSNIVSAAELTVGHILSLARHIP 128 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKL 186 +A++ G W + E KK+GIIG G IG + + + YD Sbjct: 129 QASSALKNGEWKRSKYTGIELFEKKIGIIGLGRIGALVAARLQGFETEILAYDPYITAAR 188 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 ++ L +LL SD +++H+P+ P T M+GA MK + +IN +RG +VD Sbjct: 189 AAQLGVKLVTLDELLENSDFITIHMPKTPETVGMLGADAFRKMKESAYVINVARGGLVDE 248 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL AL +AGA +DVF EP+T P EFDNV++TPH+G ST EAQE G+ Sbjct: 249 EALYTALKEGQIAGAGVDVFVKEPST-----DLPFFEFDNVVVTPHLGASTDEAQEKAGV 303 Query: 307 EVAGKLIKYSDNGSTLSAVN------FPEVSLPLHGGRRLM-HIHENRPGVLTALNKIFA 359 VA + AVN P+V + +L LT ++ A Sbjct: 304 SVAKSVRLALAGELVPDAVNVAGGVIAPDVRPGIPLIEKLGRIFTALTHASLTQIDVEVA 363 Query: 360 EQGVNIAAQYLQTSAQMG 377 + + + L+ +A G Sbjct: 364 GEIAALDVKVLELAALKG 381 Score = 43.1 bits (101), Expect = 0.018, Method: Composition-based stats. Identities = 21/83 (25%), Positives = 39/83 (46%), Gaps = 1/83 (1%) Query: 325 VNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIE 384 VN +V +P+ ++ + +RPGV+ + I +NI + + G V+ + Sbjct: 452 VNGYDVEIPI-SEHLVVVAYADRPGVIGTIGHILGMNNINIGGMQVARQTEGGQVLALLT 510 Query: 385 ADEDVAEKALQAMKAIPGTIRAR 407 D V ++ L+A+KA G R Sbjct: 511 IDSSVPQQVLEAIKAGIGAEMVR 533 >UniRef50_C6VZ76 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Dyadobacter fermentans DSM 18053 RepID=C6VZ76_DYAFD Length = 337 Score = 339 bits (870), Expect = 1e-91, Method: Composition-based stats. Identities = 87/318 (27%), Positives = 146/318 (45%), Gaps = 8/318 (2%) Query: 5 SLEKDK--IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSR 62 S +K + +K L+ + +H E L A + + ++H E +K ++ + +RS+ Sbjct: 22 SYKKSRATMKILIADSMHPSLFEMLEAQKW-DYDYHP-QYKREDIKNALPAYDGLMIRSK 79 Query: 63 THLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLL 122 T L +++ A+ L I G + +DL+ A + I VF+A N +VAE +G LL Sbjct: 80 TFLDREMLENAKNLRFIARAGAGLDLIDLNVARELNIEVFHAGTGNRDAVAEHALGMLLA 139 Query: 123 LLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI 182 L + A+ + G+W++ E GK +G+IGYG+ G+ G V YD Sbjct: 140 LFTNILRADQQVRNGIWDREGNRGVELMGKTVGLIGYGNNGSATAKRLSGFGCKVLAYDK 199 Query: 183 ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 + ++ +D++SLH+P T+ ++ + IS L+N SRG Sbjct: 200 YRDQYGDAFAAESSIEEIQREADIISLHIPLTDITRQLVNDEFISAFAKPFYLLNLSRGE 259 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSP----LCEFDNVLLTPHIGGSTQ 298 VV + A+ AL S + GA +DV E P L D V+LTPHI G T Sbjct: 260 VVQLKAVTSALESGKIKGACLDVLENEKIGKLTPEQQEVFDYLKSSDRVVLTPHIAGWTH 319 Query: 299 EAQENIGLEVAGKLIKYS 316 E+ I + ++ + Sbjct: 320 ESYVRINEVLVEQIRNWL 337 >UniRef50_B2RGZ9 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=8 Tax=Bacteroidales RepID=B2RGZ9_PORG3 Length = 319 Score = 339 bits (870), Expect = 1e-91, Method: Composition-based stats. Identities = 93/322 (28%), Positives = 145/322 (45%), Gaps = 12/322 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + L A E++ E I D + + D+I+ Sbjct: 3 KILVAFNTVSEGFDRLTARHKVVFPPKGRDFTQEEIAERIVDCDVLCSVFDIPIGRDLID 62 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 L I + +G N +D+ AA +GI V N P + A+L + LL R + E + Sbjct: 63 KGRSLKLIANYAVGYNNIDVTYAASKGIVVTNTPRAVIEPTADLALALLLSCTRRIAEWD 122 Query: 132 AKAHRG----VWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN--- 184 R +L GK LGIIG+G+IG + ++ GM V + Sbjct: 123 RLFRRDGEMVERGRLCRLGVNLYGKTLGIIGFGNIGAAVARRCKAFGMNVLYNKRTRLSE 182 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 DL+ +DV+SLH P P TK+++G E+S+MKP ++LIN +RG VV Sbjct: 183 AEEKAQGITFADKDDLIRRADVLSLHTPLTPETKHLIGTAELSMMKPTAILINTARGAVV 242 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL +AL K +A A +DVF +D + L DNV LTPH+G T +++ + Sbjct: 243 DERALVEALREKRIAAAGLDVFEN-----NDIPSPELFAMDNVSLTPHVGTQTYDSRVEM 297 Query: 305 GLEVAGKLIKYSDNGSTLSAVN 326 E+ ++ + +S VN Sbjct: 298 VHELCDNVLGFLHGDRPISRVN 319 >UniRef50_C7TNB9 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=74 Tax=Bacteria RepID=C7TNB9_LACRL Length = 325 Score = 338 bits (869), Expect = 2e-91, Method: Composition-based stats. Identities = 98/326 (30%), Positives = 152/326 (46%), Gaps = 15/326 (4%) Query: 11 IKFLLVEGVH---QKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 IK +L++G +L+ G + D +++ I DA I L +T LT+ Sbjct: 2 IKIVLLDGYALNRDLDWSALKKLGECHFYDRTPVNDTQKILARIGDAE-IVLTHKTPLTK 60 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 +I A L IG G + +D++AA+ RGIPV N P T +VA+ +L + V Sbjct: 61 AIIGKAPNLRYIGVMGDGYDVIDVEAASARGIPVTNVPIYATDAVAQFTFALILEITSHV 120 Query: 128 PEANAKAHRGVWNKLAAGSFE------ARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD 181 N H G W +F GK LG++GYG I ++ +A + M V FYD Sbjct: 121 GLHNRLVHEGRWEASPDFTFWAKKLTLLAGKTLGLVGYGRIAQKVASIAHAFSMKVVFYD 180 Query: 182 IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 K +Q L +LL +D++SLHV + P T N++ + I M+PG ++IN +RG Sbjct: 181 RRPKTHDNQMSQQVSLKELLTTADIISLHVRQAPETLNLIRRETIEQMRPGVIIINTARG 240 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 +++ L AL +A A +DV EP + PL N +TPHI + E + Sbjct: 241 KLINENDLALALNQGKIAAAGLDVSQQEPIQPDN----PLLTAKNCYITPHIAWAPYETR 296 Query: 302 ENIGLEVAGKLIKYSDNGSTLSAVNF 327 E + L + G+ + VN Sbjct: 297 EKLLALTIANLTAFLK-GTPQNVVNV 321 >UniRef50_Q0ADX2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=2 Tax=Nitrosomonas RepID=Q0ADX2_NITEC Length = 322 Score = 338 bits (869), Expect = 2e-91, Method: Composition-based stats. Identities = 88/296 (29%), Positives = 139/296 (46%), Gaps = 12/296 (4%) Query: 37 FHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAK 96 + EQ+ E I+ A I + ++ L I AA++L I G N VDL AAA+ Sbjct: 29 IYHDNTSREQVTERIKGAEII-ISNKVQLDRTAIFAADQLKLICVAATGYNNVDLAAAAE 87 Query: 97 RGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGS------FEAR 150 R IPV N T SVA+ + +L E +G W E Sbjct: 88 RNIPVCNVRNYATSSVAQHTLMFMLNFACRFVEYRQLIKKGGWQTSTYFCPLDFGVMELA 147 Query: 151 GKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLLNMSDVVSLH 210 GK LGIIG+G +G+ + +A++ GM + E K +D++ +D ++LH Sbjct: 148 GKTLGIIGHGELGSAVANIAKAFGMKLLI--AEYKSASSIRPGRMAFNDVIQQADFITLH 205 Query: 211 VPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEP 270 P + T++++G E LMKP LIN +R +++ L AL S +AGAAIDV EP Sbjct: 206 CPLSADTRHLIGKWEFDLMKPSVYLINTARSGLINEDDLLQALYSGRIAGAAIDVLQAEP 265 Query: 271 ATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVN 326 N +P N+L+TPH ++ E+++ + +A + + N + +N Sbjct: 266 PVNGNPLLD--YPHPNLLITPHSAWASVESRQRMINLLADNIRNFLQNK-PFNQIN 318 >UniRef50_C0C032 Putative uncharacterized protein n=2 Tax=Firmicutes RepID=C0C032_9CLOT Length = 319 Score = 338 bits (869), Expect = 2e-91, Method: Composition-based stats. Identities = 95/323 (29%), Positives = 155/323 (47%), Gaps = 15/323 (4%) Query: 12 KFLLV----EGVHQKALESLRAAGYTNI--EFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 K L+ E + + A + L +G+ I + EQ+ + I D + Sbjct: 3 KILITASHYEELCKGAKQLLEESGHELIINKSDMPYYTYEQIAQVIGDVDGAII-GLDDW 61 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 TE++ A KL I F +GT+ +D A + GI V NAP N+ +VAEL +G ++ +LR Sbjct: 62 TEEIYKIAPKLKVIAKFGVGTDNIDKIKAREYGIKVINAPGQNSNAVAELTVGLMIGVLR 121 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 G+ + K G W + +E +GK +G++G+G I + + G V D+ Sbjct: 122 GLIPLHKKMENGEWVRRV--GYEIKGKTIGLLGFGAIARLVAEKLMNFGAEVIASDLYPD 179 Query: 186 LPLGNATQVQHLS--DLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 L + V +S +++ SD+VS+H+P T ++ +MK G+ LIN +RG++ Sbjct: 180 AELASRCNVTMVSQKEVMTKSDLVSIHIPATGETHHLFDDAAFRMMKKGAYLINCARGSI 239 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 +D ALC AL +AGAA+D F EP + + + NV+ TPH G T EA N Sbjct: 240 IDTGALCRALKDGRIAGAALDAFEAEPLMKD----AEILKCGNVICTPHTGAETYEAYTN 295 Query: 304 IGLEVAGKLIKYSDNGSTLSAVN 326 + + A +I + N Sbjct: 296 VSMCTAQGVIDVLEGREPQFCTN 318 >UniRef50_A3CQK1 Glyoxylate reductase, NADH-dependent, putative n=10 Tax=Bacteria RepID=A3CQK1_STRSV Length = 318 Score = 338 bits (869), Expect = 2e-91, Method: Composition-based stats. Identities = 85/323 (26%), Positives = 146/323 (45%), Gaps = 14/323 (4%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K K L+ V ++ L L Y + + E + + L + +++ Sbjct: 3 KKKVLVTGIVPKEGLVKLMEK-YDVTYSDGEPFSRDYVLEHLPEYDAWLLMGQ-KGDKEM 60 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I+A + L I +G + VD++ A ++GI V N+P + AE+ LL + + Sbjct: 61 IDAGKNLQIISLNAVGFDHVDIEYAKQKGIVVSNSPQAVRVPTAEMTFALLLAATKRLAF 120 Query: 130 ANAKAHRGVW---NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN-- 184 + G W ++ G LGI G G IG+ + A++ GM V ++D+ Sbjct: 121 YDKIVRTGNWIDPSERRYQGLTLEGATLGIYGMGRIGSTVAGFAKAFGMKVLYHDLYRLP 180 Query: 185 -KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 + DL+ +DV+++H P PST + + MK S LINA+RG + Sbjct: 181 EEREKELGVSYVEFDDLVEKADVITIHAPSLPSTHHKFNKEVFKKMKNRSYLINAARGPI 240 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 V L +AL + +AGA +DVF EP + + L DNV++ PH G T E + Sbjct: 241 VSEEDLIEALKTGEIAGAGLDVFEFEPEVSEE-----LRALDNVIMAPHAGTGTIEGRRT 295 Query: 304 IGLEVAGKLIKYSDNGSTLSAVN 326 + E A ++ + + G+ ++ VN Sbjct: 296 LAAEAAANILSFFE-GNPVNVVN 317 >UniRef50_Q3KHS7 2-ketogluconate reductase n=24 Tax=Proteobacteria RepID=Q3KHS7_PSEPF Length = 326 Score = 338 bits (868), Expect = 2e-91, Method: Composition-based stats. Identities = 93/327 (28%), Positives = 144/327 (44%), Gaps = 13/327 (3%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K L + +E L+ + K + Q E++ AH + R L + Sbjct: 4 KKTVLAFSRITPPMIERLQQDFDVIVPNPKNGDINAQFNEALPHAHGLIGVGR-KLGKAQ 62 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 + A KL + +G + DL +RGI + N P T S A+L ++ R V E Sbjct: 63 LENAAKLEVVSSVSVGYDNYDLAYFNERGIMLTNTPDVLTESTADLAFALIMSSARRVAE 122 Query: 130 ANAKAHRGVWNKLAA---GSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYF--YDIE 183 +A G W + GK LGI+G G+IG + M + + + Sbjct: 123 LDAWTKAGQWQASVGAPLFGCDVHGKTLGIVGMGNIGAAVARRGRFGFNMPIIYSGNSRK 182 Query: 184 NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 +L Q + L LL +D V L VP + T++++ +E++LMKP ++L+N SRG V Sbjct: 183 TELEQELGAQFRSLDQLLAEADFVCLVVPLSDKTRHLISHRELALMKPDAILVNISRGPV 242 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 VD PAL +AL + + GA +DV+ EP SPL + N + PHIG +T E +E Sbjct: 243 VDEPALIEALQNNRIRGAGLDVYEKEPLAE-----SPLFQLKNAVTLPHIGSATNETREA 297 Query: 304 IGLEVAGKLIKYSDNGSTLSAVNFPEV 330 + L VN P+V Sbjct: 298 MANRALTNLRSALLGERPQDLVN-PQV 323 >UniRef50_A4YUP8 Putative D-3-phosphoglycerate dehydrogenase (PGDH) n=4 Tax=Proteobacteria RepID=A4YUP8_BRASO Length = 335 Score = 338 bits (868), Expect = 2e-91, Method: Composition-based stats. Identities = 102/316 (32%), Positives = 165/316 (52%), Gaps = 11/316 (3%) Query: 10 KIKFLLVEG-VHQKALESLRAAGYTNIEFHKGALDDEQLKESIR--DAHFIGLRSRTHLT 66 + K L+ + +A G ++ + A ++L E I +R + Sbjct: 11 RYKLLITGPALTAEATAIAARRGAALVDNPRYA-SPQELAEITAREQPDGIIVRQG-KID 68 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 + VI A++KL AI +G + +D++AA +RGIPVF A +N++SVAEL + + R Sbjct: 69 DQVIGASQKLKAIAKHGVGYDNIDVEAADRRGIPVFVARGANSQSVAELAFALMFAVARE 128 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--N 184 +P +A+ G W+K + G+ LG+IG+G IG L L + L M V +D Sbjct: 129 IPHLDARIKTGHWDKATTKGAQLLGRSLGVIGFGEIGRILVGLVQPLHMEVRIFDPYMPA 188 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + A + L ++L SDV+SLH P P T+NM+G +++ M+ ++LIN +RG ++ Sbjct: 189 DAEISGAERAGSLDEILTASDVISLHCPLMPQTRNMIGRDQLARMRRNAILINTARGGLI 248 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL DAL +AGA +D F EPA PL NV++TPH G STQEA++ + Sbjct: 249 DEAALYDALRDGVIAGAGLDSFAEEPAKPD----LPLLALSNVVVTPHAGASTQEARDAM 304 Query: 305 GLEVAGKLIKYSDNGS 320 G+ ++ + + Sbjct: 305 GVIAVNHVMDVLEGKT 320 >UniRef50_A1W7V5 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=3 Tax=Bacteria RepID=A1W7V5_ACISJ Length = 337 Score = 338 bits (867), Expect = 3e-91, Method: Composition-based stats. Identities = 97/337 (28%), Positives = 150/337 (44%), Gaps = 26/337 (7%) Query: 11 IKFLL--VEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 +K L+ E +A + L G+ + DE + DA I + LT + Sbjct: 1 MKILVVETEEWEHRACQRLLP-GHKLVCRSNALGPDEPTAD--NDAEVITPFVHSRLTAE 57 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 V+ +L I G + +DLD GI V N P +VAE LL + R + Sbjct: 58 VLAQFPRLRLIATRSTGYDHIDLDYCRAHGIAVSNVPDYGDATVAEHAFALLLAVSRHIV 117 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL 188 + RG +++ FE RGK LG++G G IG ++ + + GM + YD+ + Sbjct: 118 TGAERTRRGDFSQHGLRGFELRGKTLGVLGTGRIGRRVIEIGKGFGMKIVAYDLFPDAAV 177 Query: 189 GNATQVQHLS--DLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 ++L LL+ +DVV+LHVP P T +++G E + MK G++LIN +RG VVD Sbjct: 178 AEHLGYEYLDLHVLLSQADVVTLHVPATPQTHHLLGDPEFAAMKKGAVLINTARGGVVDT 237 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSD------------------PFTSPLCEFDNVL 288 AL AL+++ L A +DV P EP + L F NV+ Sbjct: 238 SALVRALSARKLRAAGLDVLPAEPLIREEAEIFRNDRRNSDTDLRALLADHVLLRFSNVI 297 Query: 289 LTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAV 325 +TPH+ T EA I + ++ G + V Sbjct: 298 VTPHVAYDTDEALRRILDTTIANIEAFAR-GQPRNLV 333 >UniRef50_Q7D366 Putative phosphoglycerate dehydrogenase n=1 Tax=Agrobacterium tumefaciens str. C58 RepID=Q7D366_AGRT5 Length = 317 Score = 338 bits (867), Expect = 3e-91, Method: Composition-based stats. Identities = 95/305 (31%), Positives = 149/305 (48%), Gaps = 10/305 (3%) Query: 22 KALESLRAAGYTNIEF-HKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIG 80 A L A G +E + ++L + D + T E V N A +L AI Sbjct: 18 DAKAMLAAEGIDVVENGFGRPMTFDELSARLGDVDAVIAGVDT-WNERVFNLAPRLKAIA 76 Query: 81 CFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWN 140 F +G + +D+DAA + GI V NAP N +VAEL +G +L +R +P + G W+ Sbjct: 77 RFGVGVDNIDIDAAHRHGIAVTNAPGGNANAVAELTLGLILSAMRRIPYLHDALRGGAWD 136 Query: 141 KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IENKLPLGNATQVQHLS 198 + E G+++G++G+G+I ++ + V YD + ++ + Sbjct: 137 R--FVGQELIGRRVGLLGFGNIARKIARKLCGFDVEVIAYDKFPDQVAATKLGVRMCEMD 194 Query: 199 DLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHL 258 ++L+ SD++ + +P P T+ +M A + MKPGS+ IN +RG +VD AL DAL S HL Sbjct: 195 EVLSSSDILVMMMPSLPETRRLMDAGRFARMKPGSIFINTARGALVDEKALYDALVSGHL 254 Query: 259 AGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDN 318 AAIDV+ TEPA + PL ++ TPH T E +IG A +I N Sbjct: 255 QAAAIDVYETEPALPDN----PLFTLPQIVTTPHTAAETYETYTSIGRITAEAVIDVLAN 310 Query: 319 GSTLS 323 + Sbjct: 311 RQPRN 315 >UniRef50_A4YFM2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Metallosphaera sedula DSM 5348 RepID=A4YFM2_METS5 Length = 324 Score = 338 bits (867), Expect = 3e-91, Method: Composition-based stats. Identities = 98/316 (31%), Positives = 161/316 (50%), Gaps = 14/316 (4%) Query: 14 LLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAA 73 ++VE + Q+ + L + + F+ A ++Q+ +RDA I R + ++ +I Sbjct: 11 VIVEELDQEKVRELNSLA-EIVYFNPYA-PEDQIVSLLRDAIAIVDR-KAKISSKIIREL 67 Query: 74 EKLVAIGCFCIGTN--QVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 L I G + +VDL AA +R I + P N+ +VAEL I + L R V Sbjct: 68 RNLKLIARTGAGVDETRVDLKAAKERDIIITYNPGGNSVAVAELTIMLAIALYRKVIPLA 127 Query: 132 AKAHRGVWNKLAA---GSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKL 186 G W++L E GK GI+G+G+IG ++ L SL V YD +++ Sbjct: 128 LSVKAGKWSELKPKDTMGHELEGKAWGILGFGNIGKRVAQLVTSLNCKVLGYDPYVSSEI 187 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + + L +LL+ SD++S+HVP ST++++ ++ + MK ++LIN SRG ++D Sbjct: 188 MEKHGVKSLSLEELLSKSDIISIHVPLTESTRHLINSERLKTMKKTAILINVSRGGIIDD 247 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL ++L + +AGAA+D EP + PL DNV++TPHIGGST EA Sbjct: 248 KALYESLRNGEIAGAALDTPEEEPVKVDN----PLLSLDNVIITPHIGGSTFEASIKNAN 303 Query: 307 EVAGKLIKYSDNGSTL 322 ++I++ L Sbjct: 304 SAVEEVIRFLKGLPPL 319 >UniRef50_A7VWU5 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753 RepID=A7VWU5_9CLOT Length = 321 Score = 338 bits (867), Expect = 3e-91, Method: Composition-based stats. Identities = 99/325 (30%), Positives = 153/325 (47%), Gaps = 14/325 (4%) Query: 10 KIKFLLVEGVH----QKALESLRAAGYTNIEFH-KGALDDEQLKESIRDAHFIGLRSRTH 64 K K L ++ + A E L G+ IE+ + +++K +D + Sbjct: 2 KKKVLSTVTLYSQRCKSAKELLEKEGFEVIEYQGDTVMTADEIKAVGKDICGAII-GCDE 60 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 E++ A L AIG F +G N +DL+AA + G+ V A N SVAE I +L L Sbjct: 61 WNEEIFQACPNLKAIGRFGVGYNNIDLEAAKRHGVKVSIATGINADSVAENTILLVLASL 120 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLG-MYVYFYDIE 183 R + + RG W + + G R K G++G+G I + L ++ G + YD Sbjct: 121 RDLVNLDNAVRRGEWVRDSTGRI-IRNKVYGLVGFGAIARYVAKLVKAFGPARIIAYDKY 179 Query: 184 NKLPLGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 ++ ++ SD++S+HVP P T M G KE MK ++ +N +RG Sbjct: 180 PNYEEAEKLGVEIVDFDTVVKESDIISVHVPATPETYKMFGEKEFKAMKDSAVFVNVARG 239 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 +VVD A+ AL K +A AA DVF EP P +PL E DN+++ PH+ G T E Sbjct: 240 SVVDEAAMYKALKEKWIARAATDVFEEEP----TPKDNPLFELDNIVMMPHMCGDTWETF 295 Query: 302 ENIGLEVAGKLIKYSDNGSTLSAVN 326 E +GL A +I + + +N Sbjct: 296 EAVGLFSAQVIIDVMNGKDPKNWIN 320 >UniRef50_A4FIF2 D-3-phosphoglycerate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FIF2_SACEN Length = 316 Score = 337 bits (866), Expect = 3e-91, Method: Composition-based stats. Identities = 110/307 (35%), Positives = 157/307 (51%), Gaps = 11/307 (3%) Query: 20 HQKALESLRAAGYTNIEFHKG-ALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVA 78 ++ E L AAG + H+ A+ + L + +A + + +T +VI A +L Sbjct: 15 SREPWEILEAAGSAAVRPHETRAMPADDLLARVPEADALIV-GMDLVTAEVIEAGPRLRV 73 Query: 79 IGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGV 138 I +G + +DLDAA RGIPV AP SN+R+VAEL G ++ R + A+ G Sbjct: 74 IAKHGVGVDNIDLDAARARGIPVVFAPGSNSRAVAELTFGLMIAAARRIAAAHTAVVAGD 133 Query: 139 WNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--ENKLPLGNATQVQH 196 W KL E G+ LG+IG+G IG L A++ GM V YD ++ + Sbjct: 134 WPKLY--GPELAGRTLGVIGFGRIGRLLAGYAQAFGMTVVGYDPFLDDGELTERGVRPVS 191 Query: 197 LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASK 256 S+ L MSD VSLH+P P ++ + + MKPG+ L+NA+RG +VD AL + L S Sbjct: 192 FSECLAMSDFVSLHLPAEPGRPPLLDQRALRTMKPGACLVNAARGGLVDESALAELLHSG 251 Query: 257 HLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYS 316 HL AA D F TEP SPL NVLLTPHIG + EA ++G+ VA + + Sbjct: 252 HLGAAACDAFATEPLA-----DSPLRTAPNVLLTPHIGACSHEANRDMGVMVAQDVARVL 306 Query: 317 DNGSTLS 323 Sbjct: 307 RGEQPHH 313 >UniRef50_A8R8D3 Putative uncharacterized protein n=2 Tax=unclassified Erysipelotrichaceae RepID=A8R8D3_9FIRM Length = 310 Score = 337 bits (865), Expect = 4e-91, Method: Composition-based stats. Identities = 99/317 (31%), Positives = 147/317 (46%), Gaps = 15/317 (4%) Query: 11 IKFLLV----EGVHQKALESLRAAGYTNIEFHKG-ALDDEQLKESIRDAHFIGLRSRTHL 65 +K L+ QK +E +R AG G A E+ K+ +DA I + L Sbjct: 1 MKVLITPRGFAKYGQKEIERMRNAGLEVHYNDTGLAYTHEEFKKLGKDADAIIV-GVDCL 59 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 +++ L + F +GT+ ++LD A I + N+RSVAE V+ + + Sbjct: 60 DAKMMSDCPNLKVVCKFGVGTDNINLDYAKAHNIYIGRCVGGNSRSVAEHVVALMFAEAK 119 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD---I 182 + A + W K E GK+LGIIG+G IG L A +GM +Y YD I Sbjct: 120 NLYYAINEVKDHKWTK--PTGLEIYGKRLGIIGFGMIGKYLADYANGMGMDIYAYDAFPI 177 Query: 183 ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 + + +V L ++ D +SLHVP STKNM+ KE MK + +INA+RG Sbjct: 178 SKEEAQKHHVKVASLDEIYAECDYISLHVPLLDSTKNMISTKEFKSMKNSACIINAARGG 237 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 VVD AL +AL + + A DV+ +EP +D L +N LTPH TQEA+ Sbjct: 238 VVDEEALYEALTTGEIRSACFDVYSSEPPKEND----KLLALENFYLTPHTAARTQEAET 293 Query: 303 NIGLEVAGKLIKYSDNG 319 A +++ Sbjct: 294 RTCEISANIVMEQLLGK 310 >UniRef50_Q1GAM7 D-isomer specific 2-hydroxyacid dehydrogenase n=1 Tax=Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 RepID=Q1GAM7_LACDA Length = 322 Score = 337 bits (865), Expect = 5e-91, Method: Composition-based stats. Identities = 91/327 (27%), Positives = 157/327 (48%), Gaps = 15/327 (4%) Query: 6 LEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 L+ + K L+ G+ + L L + F + ++ D + + + + Sbjct: 5 LKMENAKVLVA-GLAVRQLPELEKVC--EVTFAPAGAGKDWYLANLGDFDAL-ITGKLPV 60 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 +++++A +KL + +G + +D+D A+ +GI V N P S + AE+ LL L R Sbjct: 61 DQELLDAGKKLKIVSATGVGYDHIDVDYASSQGIIVSNCPASVMQPTAEMAFTLLLALSR 120 Query: 126 GVPEANAKAHRGVWNKLA---AGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI 182 + N + + + GK LGI G G IG L A + GM + +++ Sbjct: 121 KLALYNQEMRQENFLDTGLLENQGQSPVGKTLGIFGMGRIGKTLASYARTFGMNILYHNR 180 Query: 183 E---NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINAS 239 L+DLL+ +D VSL+ P T +++ +S+M+P + LIN S Sbjct: 181 HQLPEDEERALGVSYVPLADLLSQADYVSLNAPATAETYHVIDEAALSMMQPTAFLINTS 240 Query: 240 RGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQE 299 RG+ VD AL AL K +AGA +DVF EP F C+ DNV+LTPH G +T+E Sbjct: 241 RGSQVDEAALLRALKGKRIAGAGLDVFEEEP-----DFNKEFCQLDNVILTPHAGSATRE 295 Query: 300 AQENIGLEVAGKLIKYSDNGSTLSAVN 326 ++ ++ E + ++ + +G ++ VN Sbjct: 296 SRRSVLKEASHNIVSFLVDGVPVNRVN 322 >UniRef50_A1W9A3 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=2 Tax=Acidovorax RepID=A1W9A3_ACISJ Length = 339 Score = 337 bits (865), Expect = 5e-91, Method: Composition-based stats. Identities = 88/290 (30%), Positives = 137/290 (47%), Gaps = 17/290 (5%) Query: 55 HFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAE 114 + + RT + E V+ +L + G + +DL+A KRGI V + P + SVAE Sbjct: 51 EVLCVFVRTRVDESVLRMLPRLRLVATRSAGFDHIDLEACRKRGIAVCHVPDYGSASVAE 110 Query: 115 LVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLG 174 LL + R + +A+ +A +G + FE G+ LGI+G G IG + +A G Sbjct: 111 HAFALLLGVTRHLTQAHERARQGSFAYRGLTGFELEGRTLGIVGLGRIGRHVARIAVGFG 170 Query: 175 MYVYFYDI--ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPG 232 M V YD + +L SD++SLHVP +T++++ A+ + MKPG Sbjct: 171 MDVLAYDPAFAASAARPAGVSLVTWEQVLQGSDILSLHVPATEATRHLIDARAFARMKPG 230 Query: 233 SLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFT-------------- 278 ++IN +RG ++D AL AL +A A +DV E A + + T Sbjct: 231 VVVINTARGALIDEAALLRALDDGSVAAAGLDVLEQEGALSPEVPTGCGGLGCDTGWMAS 290 Query: 279 SPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFP 328 SPL VL+TPH+G +T EA I E + + G + V+ P Sbjct: 291 SPLLTHPRVLVTPHVGFNTTEAIARIFDETISNIAAW-HAGRLRNRVDEP 339 >UniRef50_B2IKB7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=8 Tax=Proteobacteria RepID=B2IKB7_BEII9 Length = 331 Score = 337 bits (865), Expect = 5e-91, Method: Composition-based stats. Identities = 102/331 (30%), Positives = 157/331 (47%), Gaps = 12/331 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 L+ +H+ L+ LR A ++ + E + A I +R++ L E VI+ Sbjct: 3 HILVAGRIHEAGLDILRNASGITLDLVD-EVSTESYAPLVDRADAILIRTQ-PLPESVID 60 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A+KL + +G + VD++A +R IP+ N+RSVAE + +L + + V + Sbjct: 61 RAQKLKFVSRHGVGYDVVDVEALTRRNIPLAIVGDVNSRSVAEHAMMLMLAVAKRVCVYD 120 Query: 132 AKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI---ENKLP 187 A G W + + + GK L +IG+G IG + +A M + YD E + Sbjct: 121 AATRAGKWGIRNDLYATDISGKTLLLIGFGRIGRLVASMARGFDMTILAYDPFLDEAAIK 180 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 A + L L +D VSLH+P P ++G E++ MKPG++LIN +RG VVD Sbjct: 181 AAGAIPTRDLEGALRSADFVSLHMPP-PRNGALLGESELASMKPGAILINTARGGVVDEK 239 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL AL LAGA +DVF EP P PL + D V+LTPH T+E + + Sbjct: 240 ALAKALTDGRLAGAGLDVFTQEPP----PADHPLLQMDRVILTPHSAVMTRECAARMAVS 295 Query: 308 VAGKLIKYSDNGSTLS-AVNFPEVSLPLHGG 337 + ++ Y S VN +S P Sbjct: 296 ASRNILDYFAGRLDPSLVVNGEVLSAPARES 326 >UniRef50_B8J355 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Desulfovibrio RepID=B8J355_DESDA Length = 309 Score = 337 bits (865), Expect = 5e-91, Method: Composition-based stats. Identities = 81/311 (26%), Positives = 144/311 (46%), Gaps = 15/311 (4%) Query: 11 IKFLLV----EGVHQKALESLRAAGYTNIEFHKGA-LDDEQLKESIRDAHFIGLRSRTHL 65 +K L+ + + + L AG + G L +Q++E + + L + Sbjct: 1 MKILVTPRSFGKTNPELFDRLTQAGLEVVRNDTGGILSADQMREKLAGCQGVIL-GVDPM 59 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 + DV+ AA +L AI + +G + +DL+A +RGI V +N+ +VA+ + +L++ R Sbjct: 60 SADVLAAAPELRAIAKYGVGLDNIDLEACKQRGIAVSRTVGANSNAVADYALTLMLMVAR 119 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--E 183 + + W K+ S + GK LGI+G G IG + A+ GM + +DI + Sbjct: 120 KAGLIDRRCREKDWGKIT--SIDLYGKTLGIVGLGAIGRCVVKRAQGFGMKILGHDIAWD 177 Query: 184 NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 + + + +D ++LH T+N + I++MK +++IN +RG + Sbjct: 178 EAWASAEGVERADMDRICREADFITLHTVLTDETRNCISTGRIAMMKKTAVIINTARGGL 237 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 +D AL AL + GA +DVF EP P DN+++ H ST A E Sbjct: 238 IDETALLTALQEGRIYGAGLDVFEQEP-----PADPAWYALDNLVMGSHCSSSTAGATET 292 Query: 304 IGLEVAGKLIK 314 +G L++ Sbjct: 293 MGRMAVDNLLR 303 >UniRef50_Q8EMM3 Dehydrogenase n=5 Tax=Bacteria RepID=Q8EMM3_OCEIH Length = 329 Score = 336 bits (864), Expect = 6e-91, Method: Composition-based stats. Identities = 90/327 (27%), Positives = 155/327 (47%), Gaps = 17/327 (5%) Query: 12 KFLLVEGVH---QKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 K L+ + H E+ + A + + +E L + + + +T Sbjct: 5 KVLITDCDHGNVDVESETFKKAEISF--DLEQCKTEEDLISKGKGFE-VFINQYAPVTRS 61 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 VI L + + +G + VD+ AA + G+ V N P VA+ + +L R + Sbjct: 62 VIENLPDLKLVVRYGVGVDNVDIAAATEHGVQVCNVPDYGMNEVADQALAMMLNFTRSIS 121 Query: 129 EANAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI----- 182 N+ +GVW+ + + + + +G+IG G IG+ +SLG V YD Sbjct: 122 RMNSFVRKGVWDYQKSMPLYRHSEQTVGVIGVGRIGSSFAKKVKSLGCRVVAYDPKYLDE 181 Query: 183 ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 + K + L++LL +DVVS+H P + + +N++ KE+ MKP + LIN SRG Sbjct: 182 KAKKSPDFIDEFLPLNELLEQADVVSIHCPLDKA-RNLIDEKELQKMKPTAYLINVSRGG 240 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 +++ AL AL ++ +AGAA+DV EP S L E DN + TPH+G +++A Sbjct: 241 IINEQALNKALTNQWIAGAAVDVAENEPLQPE----SALLEHDNFICTPHMGWYSEQAAL 296 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVNFPE 329 + +VA + I++ + +NF E Sbjct: 297 ELKRKVAEESIRHLNGDQVHYPINFKE 323 >UniRef50_C4TXE2 D-3-phosphoglycerate dehydrogenase n=3 Tax=Bacteria RepID=C4TXE2_YERKR Length = 317 Score = 336 bits (864), Expect = 7e-91, Method: Composition-based stats. Identities = 104/312 (33%), Positives = 148/312 (47%), Gaps = 28/312 (8%) Query: 39 KGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRG 98 + L ++QL +DA F+ + S +T VI A +L I C +D+ AA +RG Sbjct: 10 EPKLSEDQLIALGQDADFL-VTSYDDITARVIKACPQLKLIACTRASPVNIDVKAATERG 68 Query: 99 IPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGV----------------WNKL 142 IPV P N+ + AEL I +L + R +P+A++ +G W+ Sbjct: 69 IPVIYTPGRNSDAAAELTIALMLNVARHIPQAHSALKQGQFTATEQSHFGLKTDVVWDVT 128 Query: 143 A------AGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL--GNATQV 194 E R K LGI+GYG IG ++G +A + GM + D Sbjct: 129 KDSPYEVFKGIELRNKTLGIVGYGSIGQRVGRIARAFGMQLLVADPYVSEVELDEPGIHK 188 Query: 195 QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALA 254 L L + +D VSLH+ P T+ ++ A SLMKP + IN SR VV L DAL Sbjct: 189 STLEQLFSQADFVSLHLKVTPQTEGLIDAHLFSLMKPEAYFINTSRAAVVVEQHLIDALR 248 Query: 255 SKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIK 314 K LAGAA+DV+ EP S PF EFDNV++TPHI G+T+E +A + + Sbjct: 249 HKQLAGAALDVYAHEPIHASHPFIH---EFDNVVITPHIAGATRETLVKHTAMIAQDIER 305 Query: 315 YSDNGSTLSAVN 326 + N L N Sbjct: 306 FLRNEPLLYRYN 317 >UniRef50_C5RAQ7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Weissella paramesenteroides ATCC 33313 RepID=C5RAQ7_WEIPA Length = 329 Score = 336 bits (863), Expect = 8e-91, Method: Composition-based stats. Identities = 96/333 (28%), Positives = 161/333 (48%), Gaps = 16/333 (4%) Query: 4 VSLEKDKI----KFLLVEGVHQKALE-SLRAAGYTNIEFHKGALDDEQLKESIRDAHFIG 58 +S K + K ++ + + + L GY I D + DA + Sbjct: 7 ISYHKGAMIMADKVIIP-KISDELTDHYLSKKGYEVITIDNPGQKD--ILNLAPDAAAVM 63 Query: 59 LRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIG 118 + S+ ++ D+ L + +G + +D+D AAK+G+ V N P +N SVAE+ + Sbjct: 64 MVSK-KISNDIYRQMPNLKILARRGVGYDNIDVDFAAKQGVWVTNTPGANAHSVAEMALM 122 Query: 119 ELLLLLRGVPEANAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYV 177 +L L R + W + +GI+GYGH+G +L L +LG+ V Sbjct: 123 NMLQLRRQFRLVDKLTRDDQWAGAYQLLGQDLTAATIGIVGYGHVGQELARLLTALGVKV 182 Query: 178 YFYDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLIN 237 YD + K + + +D++SLH+ P T++++G +E MKP S +IN Sbjct: 183 IIYDRKQKSSPYG--KFVSWQKMFETADIISLHLAAVPETRHIVGDREFQWMKPESAMIN 240 Query: 238 ASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGST 297 +RG ++D +L AL +K +AGAA+DVF EP T+PL + DNV++TPHIG +T Sbjct: 241 LARGQIIDEQSLIWALQNKQIAGAALDVFQQEPIDK----TNPLLKMDNVIVTPHIGANT 296 Query: 298 QEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEV 330 Q+A + + + A + + AVN P + Sbjct: 297 QQANQKMAMIAAKMIDTVLRGAAPKYAVNNPII 329 >UniRef50_A9CLC8 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=4 Tax=Alphaproteobacteria RepID=A9CLC8_AGRT5 Length = 349 Score = 336 bits (863), Expect = 9e-91, Method: Composition-based stats. Identities = 92/312 (29%), Positives = 157/312 (50%), Gaps = 10/312 (3%) Query: 13 FLLVEG-VHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRT-HLTEDVI 70 L+ ++++A++ + GY + + + L + + +G+ R +E I Sbjct: 25 ILVTGPAINEQAVKLITDNGYQ-VSYVPPYTSEADLVRIVTELDPVGVVVRMGRFSEAAI 83 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA L + +G + +D+DAA++R IPV A +N SVAE I L +++ + Sbjct: 84 KAAPSLRVLSKHGVGVDNIDVDAASRREIPVVVAAGANALSVAEHAITLLFAVVKRIVPL 143 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI---ENKLP 187 ++ G W K E G +G++G+G I Q + A G+ V YD E Sbjct: 144 DSGIRAGRWEKAGYSGKELAGMIIGLVGFGAIARQTAVFARGFGLKVQAYDPFTDETAFV 203 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 +V + DL++ SD++SLH P P T+N++ + + +MKPGS +IN +RG ++D Sbjct: 204 EAGVHRVADVDDLISSSDILSLHCPLTPDTRNLLDDRRLGMMKPGSFIINTARGGLIDED 263 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL A+ S H+AGA +D F EP + PF + +++TPHIGG TQEA +G++ Sbjct: 264 ALLRAVESGHIAGAGLDTFQIEPPAANHPF----WQNQKIVVTPHIGGVTQEANVRVGVD 319 Query: 308 VAGKLIKYSDNG 319 + + Sbjct: 320 AVEGIFAIVEGR 331 >UniRef50_B1M476 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=3 Tax=Proteobacteria RepID=B1M476_METRJ Length = 326 Score = 336 bits (863), Expect = 9e-91, Method: Composition-based stats. Identities = 107/328 (32%), Positives = 150/328 (45%), Gaps = 12/328 (3%) Query: 14 LLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAA 73 L+V+ +H L+ LRAAG D E L + D + R+ T I AA Sbjct: 7 LIVQPIHAAGLDRLRAAGLE--PRPASGTDSETLAREVADCVAVITRN-TGFPARAIAAA 63 Query: 74 EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAK 133 L IG GT+ V A GI V N P +N SVAE + + L + +PEA+ Sbjct: 64 PALRVIGVHGTGTDHVATAEATAAGIVVVNTPGANAVSVAEQTLALIFALAKALPEADRS 123 Query: 134 AHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN---KLPLG 189 G + K A E G LG++G+G IG LA +LG+ V Y Sbjct: 124 VRTGDDSFKFTARLIELAGLTLGLVGFGAIGQATARLAAALGLRVLAYGPSRPDADFANA 183 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 A + + LL +D+VSLHVP P T+ ++G +++ MK + LIN SRG ++D AL Sbjct: 184 GALRAASVDALLAEADIVSLHVPLTPGTRGLIGRDQLARMKREAFLINTSRGGLIDEAAL 243 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 +AL + +AGA +DVF EP P PL +LTPH+GGST A A Sbjct: 244 VEALEAGTIAGAGLDVFAQEPL----PVDHPLARQPRAILTPHVGGSTGAALIRTAETAA 299 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPLHGG 337 +++ VN P+V Sbjct: 300 TRVVDVLAGRRPGGLVN-PDVWERRRAP 326 >UniRef50_Q160B1 Glyoxylate reductase n=24 Tax=Bacteria RepID=Q160B1_ROSDO Length = 330 Score = 336 bits (863), Expect = 9e-91, Method: Composition-based stats. Identities = 87/327 (26%), Positives = 145/327 (44%), Gaps = 14/327 (4%) Query: 8 KDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 K++ + L+ + L T + + ++++ I LT Sbjct: 8 KNRPRVLVTRRWPESVEAQLAERFDTVFNVDDTPMTPAEFRDALTRFDAILPTVTDRLTT 67 Query: 68 DVIN-AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 + + ++ K + + +G + +D+ AA GI V N P + A+L + LL++ R Sbjct: 68 EAFDISSPKTRLLANYGVGFSHIDIAAAKAHGIAVTNTPDVLSECTADLAMTLLLMVARR 127 Query: 127 VPEANAKAHRGVWNKLAAG---SFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDI 182 E + G W + GK LGI+G+G IG + A GM + + Sbjct: 128 AGEGERELRAGQWTGWRPTHLVGSKVSGKTLGIVGFGRIGQAMAQRAHFGFGMKILVQNR 187 Query: 183 ENK----LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINA 238 L A QV L DLL D VS+H P ++++ ++ + LMK + LIN Sbjct: 188 SRVAQEVLDRYQAVQVDTLDDLLPACDFVSMHCPGGAENRHLINSRRLDLMKSDAFLINT 247 Query: 239 SRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQ 298 +RG VVD AL +L + +AGA +DVF EP + L EFDN++L PH+G +T Sbjct: 248 ARGEVVDENALVQSLTYECIAGAGLDVFDGEPKVSP-----ALMEFDNLVLLPHLGSATA 302 Query: 299 EAQENIGLEVAGKLIKYSDNGSTLSAV 325 E + +G V +I + + + V Sbjct: 303 ETRTAMGERVLSNVIAFFEGSTPADRV 329 >UniRef50_C7H518 Glycerate dehydrogenase n=3 Tax=cellular organisms RepID=C7H518_9FIRM Length = 320 Score = 336 bits (863), Expect = 9e-91, Method: Composition-based stats. Identities = 93/327 (28%), Positives = 152/327 (46%), Gaps = 19/327 (5%) Query: 11 IKFLLVEG-VHQKALESLRAAGYTNIEFHKGAL---DDEQLKESIRDAHFIGLRSRTHLT 66 +K +++E V ++ L +G + + E++ I DA + L ++ + Sbjct: 1 MKAVILESYVMEEG--DLDWSGVKALVPDTVSYVRTAYEEIAPRIGDADIVLL-NKCRMN 57 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 E+++ L +G GT+ +DL+A + G+ V N P +T SVA++ LL + + Sbjct: 58 EEILQQCPNLKWVGIIATGTDNLDLEACRRHGVAVANVPGYSTYSVAQMTFSLLLAICQC 117 Query: 127 VPEANAKAHRGVWNKLAAGS------FEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 N +G W S E GK G+ GYG IG Q +A + GM V Sbjct: 118 AERYNRAVKQGCWQLDIPESIGLLPQMELCGKTYGVYGYGSIGRQSARIARAFGMEVLVC 177 Query: 181 DIENKLP-LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINAS 239 + + + LL D++SLH P P T+ ++ A+ ++ MKPG++L+N + Sbjct: 178 TRTVRPEYAADGVEFVDYDTLLRRCDILSLHCPATPQTRGLVNAEALAKMKPGAILLNTA 237 Query: 240 RGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQE 299 RG +VD A+ AL S L D F TEP P SPL + +LTPHI +T+E Sbjct: 238 RGALVDEEAVAAALHSGQLGFYGADAFVTEPL----PQESPLRAEPHAILTPHIAWTTRE 293 Query: 300 AQENIGLEVAGKLIKYSDNGSTLSAVN 326 A +N+ L + + G+ VN Sbjct: 294 ALQNLMDITTRNLRTWLE-GNGEHIVN 319 >UniRef50_A1AQ02 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=10 Tax=Bacteria RepID=A1AQ02_PELPD Length = 318 Score = 336 bits (862), Expect = 1e-90, Method: Composition-based stats. Identities = 92/289 (31%), Positives = 145/289 (50%), Gaps = 11/289 (3%) Query: 43 DDEQLKESIRDAHFIGLRSRTHLTEDVINAAE-KLVAIGCFCIGTNQVDLDAAAKRGIPV 101 DE++ + I + L ++I+ + I G N +D+ AA RGI V Sbjct: 36 SDEEIPSRVEG-QTIVITKELPLGRELIHCFPASVKLICEAGTGYNNIDIAAARSRGIGV 94 Query: 102 FNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGV---WNK-LAAGSFEARGKKLGII 157 N P +T +VA+L I +L L + + RG + K L FE GK LG+I Sbjct: 95 CNVPSYSTDAVAQLAITFMLNLSASLVQQQTMLRRGNLDNFQKSLQLPHFELNGKTLGVI 154 Query: 158 GYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPST 217 G+G IG ++ +A +LGM + + + L + L +LL SD VSLH P N +T Sbjct: 155 GFGEIGRRVIAIARTLGMKIIVHSRTPRPELDPDLRFVSLEELLATSDFVSLHCPLNDAT 214 Query: 218 KNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPF 277 ++++ A+ + +MKP + +IN SRG ++ PAL AL +AGA +DV EP D Sbjct: 215 RHVINAERLEMMKPTAFIINTSRGPLIHEPALSQALTRGTIAGAGLDVQEQEPPEPGD-- 272 Query: 278 TSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVN 326 PL +NV+LTPHIG E ++ + A + + + + ++ VN Sbjct: 273 --PLYSLENVILTPHIGWKRLETRQRLIGLTAANIDAFIKD-AAINIVN 318 >UniRef50_Q04DF1 D-3-phosphoglycerate dehydrogenase n=1 Tax=Oenococcus oeni PSU-1 RepID=Q04DF1_OENOB Length = 311 Score = 336 bits (862), Expect = 1e-90, Method: Composition-based stats. Identities = 97/317 (30%), Positives = 156/317 (49%), Gaps = 10/317 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K ++ + + + L + IE E + + +DA I L + + Sbjct: 1 MKVVVPKALSKAGKNYLSEHDFELIEAPDDK--QETILKVGKDADGIVLMT-DPFDNQTL 57 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 L I +G + VD A + G+ V P +N +VAE I E+L L + + + Sbjct: 58 TKFTNLKIIARHGVGFDNVDEKFAGEHGVYVTITPMANASTVAETTIAEILDLSKNLTKI 117 Query: 131 NAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 + + +G + KL F+ KK+G++GYG IG Q+ A +LGM V +D K Sbjct: 118 SDEMRQGNFAYKLDHMGFDLSHKKIGVMGYGRIGRQVAEKANALGMDVLIFDPFVKETKI 177 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 ++ L++ SDV++LH+ T + G +E+ +MK + LIN RG +VD AL Sbjct: 178 G--KLVDRDTLISQSDVITLHLAVTDQTIHGFGKRELEMMKKSASLINLGRGALVDEQAL 235 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 DAL +K + GAA+DVF EP P TS + DNVLLTPHI +T+E E + ++ A Sbjct: 236 IDALKTKQINGAALDVFDEEPL----PLTSEFYKLDNVLLTPHIASNTKECMERMAVDSA 291 Query: 310 GKLIKYSDNGSTLSAVN 326 ++++ AVN Sbjct: 292 SEVVRVLSGEKPKWAVN 308 >UniRef50_B0PA81 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PA81_9FIRM Length = 316 Score = 336 bits (862), Expect = 1e-90, Method: Composition-based stats. Identities = 94/322 (29%), Positives = 144/322 (44%), Gaps = 14/322 (4%) Query: 11 IKFLLVEG-VHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 +K ++++G + L L I+++ EQ E I A + + +R L V Sbjct: 1 MKVVVLDGFLAGYGLNGLPLPDTFKIKWYDNT-PPEQTIERIGTAEAVFV-NRLRLDARV 58 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 A L G F G N +DLDAA + G+ V N P +T +VA+ I LL + Sbjct: 59 FEACPSLRFAGTFGTGYNMIDLDAARRAGVTVCNVPAYSTAAVAQNTISLLLNIATMTHI 118 Query: 130 ANAKAHRGVWNK------LAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE 183 + G W ++ FE GK +G+IG G IG+ +G +A + GM V Y Sbjct: 119 HSRYVSTGHWTDPTDHALVSVPMFELAGKTIGLIGCGDIGSAVGRIAAAFGMRVLAYRRH 178 Query: 184 NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 G + L L SD+VSLH P P T+ M+ I MK G++L+N +RG + Sbjct: 179 PDPSAGAYIRFVALDALYAQSDIVSLHCPLTPQTRGMIDRAAIGRMKDGAVLLNTARGGL 238 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 + + DAL L A +DV EP SPL V+ TPHI +E + Sbjct: 239 LCERDVADALDCGKLYMAGLDVLCDEPPAPD----SPLARHPRVICTPHISWMPRETRAR 294 Query: 304 IGLEVAGKLIKYSDNGSTLSAV 325 + A L+ + + G+ + + Sbjct: 295 LLRAAADNLLCFLE-GNPQNVI 315 >UniRef50_C5PUM3 Glyoxylate reductase n=2 Tax=Sphingobacterium spiritivorum RepID=C5PUM3_9SPHI Length = 329 Score = 336 bits (862), Expect = 1e-90, Method: Composition-based stats. Identities = 92/327 (28%), Positives = 140/327 (42%), Gaps = 11/327 (3%) Query: 8 KDKIKFLLVEGVHQKALESLRAAGYT-NIEFHKGALDDEQLKESIRDAHFIGLRSRTHLT 66 KD +K + V Q+ L L G T + L E++ + A + L Sbjct: 2 KDIMKVYISRNVPQEGLNYLTEHGLTYTVNMENKKLTQEEVIIECQSADLLLNVGGVPLD 61 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 + + L I +G + VD+DAA+K GIPV N P + + A++ +L + R Sbjct: 62 QHFFDNCAHLKGIALASVGYDHVDMDAASKAGIPVSNTPDVLSGATADVAFLLMLAVSRK 121 Query: 127 VPEANAKAHRGVWNKLAAG---SFEARGKKLGIIGYGHIGTQLGILAES-LGMYVYFYDI 182 + G WN E GK LGI G G IG +L A++ GM V +++ Sbjct: 122 AFYRANEIREGKWNDFEFTKDLGIELNGKTLGIYGLGRIGLELARKAQAAYGMKVIYHNR 181 Query: 183 ENKLPLGNA--TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 + + +LL SDV+S+H +P T+ + + MK ++LIN R Sbjct: 182 HPNETAKRVLNAEYVNFDELLTRSDVLSVHANLSPETQYRFNKETFARMKNSAILINTGR 241 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G +V L AL + + GA +DV EP SPL +V + PHIG +T E Sbjct: 242 GKIVHEQDLYTALVNGDIWGAGLDVTDPEPMKAD----SPLLTLPSVCVLPHIGSATIET 297 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVNF 327 + N+ A LI S + VN Sbjct: 298 RTNMIKMAANNLIAASKSNHMPQIVNV 324 >UniRef50_C8QAG5 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Pantoea sp. At-9b RepID=C8QAG5_9ENTR Length = 317 Score = 335 bits (861), Expect = 1e-90, Method: Composition-based stats. Identities = 89/323 (27%), Positives = 147/323 (45%), Gaps = 16/323 (4%) Query: 11 IKFLLVEG----VHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLT 66 +K + + +L+ G+ I A L+ + D + + + T + Sbjct: 1 MKVICTSPSFAKYDATPITTLQQQGFELITLPADAPLSA-LEPHLADTVAMIV-AFTDVN 58 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 E++++ A +L + +G + ++LDA RGI V N P +N +VA+ +L R Sbjct: 59 EELLSKAPQLKIVCKHGVGVDNINLDATRARGIYVTNVPDANKHAVADFAFALILNSARQ 118 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IEN 184 + +A + G W ++ + + GK LGI+G G+IG Q+ + A+ M V +D + Sbjct: 119 LTQAAVETRAGHWPRI--FATDVYGKTLGIVGLGNIGKQVALRAKGFNMRVIAFDFYPDE 176 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 K + + + L SD ++LH P T+N+ A I MK + LIN SRG VV Sbjct: 177 KFAAEHGIEFVSMDQLTAASDFITLHTPLTNETRNLFDAARIKRMKKSAFLINVSRGGVV 236 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 + L AL +AGAA DVF EP PL N + T HI G T A I Sbjct: 237 NEQDLFQALQDNVIAGAAADVFEQEPLAE-----HPLFTLGNFIPTSHIAGYTDGAISAI 291 Query: 305 GLEVAGKLIKYSDNGS-TLSAVN 326 G ++++ G ++ +N Sbjct: 292 GERCVTQIVQCIQQGERPVNVMN 314 >UniRef50_A1AR04 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Pelobacter propionicus DSM 2379 RepID=A1AR04_PELPD Length = 357 Score = 335 bits (861), Expect = 1e-90, Method: Composition-based stats. Identities = 91/313 (29%), Positives = 153/313 (48%), Gaps = 12/313 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + L+ + +A+E L + I + +E L IRD + RS ++ D++ Sbjct: 23 MNVLIASSIDGEAIERLEQE-HQVIRAFPNS-SEESLHALIRDCEALVFRSGIRVSADLM 80 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A +L + G + +D++ A KRG+ + P + R+VAE+ +L L R + EA Sbjct: 81 GCAPRLKLLVRAGSGMDNLDVEYARKRGVQLVRIPQPSARAVAEMAFAFMLALSRRLLEA 140 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY----DIENKL 186 + G W K + R K LG++G G+ G+ + + + GM V E + Sbjct: 141 DRSMRNGRWEKHEFSGYLLRDKTLGVVGIGNTGSCVAQMGVAWGMRVIGCVQHPSREREE 200 Query: 187 PL-GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 Q+ ++ +D +S+HVP +T+ ++ A +S MKPG+ LIN +RG +VD Sbjct: 201 GFCEKGIQMLEFDQVIANADYLSIHVPLKDNTRRLLDADALSRMKPGAYLINLARGGIVD 260 Query: 246 IPALCDALA-SKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 AL ++L + L GAA+DV E SPL +NV+LTPHIG +AQ I Sbjct: 261 EQALYESLTHNGGLRGAALDVHEHE----GQGCMSPLAMLNNVILTPHIGAMAIDAQREI 316 Query: 305 GLEVAGKLIKYSD 317 G +V + +++ Sbjct: 317 GQKVVEIIDAFAN 329 >UniRef50_A0Y9Y1 Glyoxylate reductase n=3 Tax=unclassified Gammaproteobacteria RepID=A0Y9Y1_9GAMM Length = 326 Score = 335 bits (861), Expect = 1e-90, Method: Composition-based stats. Identities = 91/331 (27%), Positives = 143/331 (43%), Gaps = 12/331 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K + + + L L + KG++ ++L + I + ++IN Sbjct: 3 KVFVTYNMPAEQLSRLSEYCDVDAWQGKGSIPRDELMARVEGVDGIICLLTERIDGELIN 62 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 +++ L A+ C +G + VD+ RGIP+ + P + A+L G LL R +P+ + Sbjct: 63 SSKNLKAVSCVSVGVDHVDVGTLTARGIPLGHTPGVLVDATADLAFGLLLAAARRIPQGD 122 Query: 132 AKAHRGVWN-----KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL 186 G W A GK LGIIG G IG L A M V + + Sbjct: 123 RHVRTGGWQGASWSPKAFLGCSVAGKTLGIIGLGDIGQALARRAAGFDMPVIAWSRSGRE 182 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 G + L +L+ SD VS++V T+ ++ A +S MKPG++L+N +RG +VD Sbjct: 183 VAG--VRTLSLEQVLDQSDFVSINVALTEETRGLIDAAALSKMKPGAILVNTARGGIVDE 240 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL AL +AGA DVF EP + + L + N + TPHIG +T E + + Sbjct: 241 RALAQALKEGRIAGAGFDVFEKEPVSPGN----ALFDQPNFIATPHIGSATPETRLAMMD 296 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEVSLPLHGG 337 + + N PEV H Sbjct: 297 LAVANMCAAMWSEKMPCCFN-PEVYADHHDN 326 >UniRef50_UPI0001973D95 D-3-phosphoglycerate dehydrogenase n=1 Tax=Clostridium sp. M62/1 RepID=UPI0001973D95 Length = 322 Score = 335 bits (861), Expect = 2e-90, Method: Composition-based stats. Identities = 101/321 (31%), Positives = 161/321 (50%), Gaps = 11/321 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K +L E L+ N++ ++ E+ + + DA + LR +DVI Sbjct: 3 KVVLAGNYPAHTYERLKTM-LENLDCTLTKVETEEEYQKMTDAEIMVLRI-FKARQDVIE 60 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 + L I + G + VD++AA K G+ V N P +N +V+EL + +L + R + + Sbjct: 61 RNKGLKMIIRWGAGFDSVDIEAAGKNGVVVANTPGANAPAVSELAVMLMLAVGRHLIDHM 120 Query: 132 AKAHRGVWNKLAA--GSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI---ENKL 186 +GVW+K S+ K +GIIG G+IG Q A++ G + +YD + Sbjct: 121 DSLRKGVWSKNTYINQSYTLNRKLVGIIGAGNIGRQTAKKAQAFGAEIQYYDPFRLSPER 180 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + L LL SDV+SLHVP S ++M+GA+EIS MK G++L+N +RG +VD Sbjct: 181 EQELGLRYVPLETLLKTSDVISLHVPLTDSNRHMIGAEEISQMKDGAILVNTARGGLVDD 240 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL +A+ S LAGA +DV EP D L +++TPH+GG T + + I Sbjct: 241 QALAEAVRSGKLAGAGLDVVENEPLKEDDS----LLTTPGIVVTPHVGGGTADIGDEILP 296 Query: 307 EVAGKLIKYSDNGSTLSAVNF 327 +A ++ + + AVN Sbjct: 297 MLAKEIERVINGQMPEHAVNL 317 >UniRef50_D1CAH7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1CAH7_SPHTD Length = 348 Score = 335 bits (860), Expect = 2e-90, Method: Composition-based stats. Identities = 98/320 (30%), Positives = 146/320 (45%), Gaps = 20/320 (6%) Query: 28 RAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTN 87 A G FH LD++ +A + + + L + +L I G + Sbjct: 27 EALGPLAPVFHSEPLDEDS-THLAAEAEIVSVFIHSRLDRPTLERLPRLRLIATRSTGYD 85 Query: 88 QVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSF 147 +DL A A+RG+ V N P+ +VAE G +L L R + A + RG ++ F Sbjct: 86 HIDLAACAERGVVVTNVPYYGENTVAEHTFGLILALSRNIHRAYVRTQRGDFSLAGLEGF 145 Query: 148 EARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IENKLPLGNATQVQHLSDLLNMSD 205 + +GK LG+IG G IG + +A+ GM V +D LP + L +LL +SD Sbjct: 146 DLKGKTLGVIGTGSIGLHVIRIAKGFGMEVVAHDLRPSRILPEVLGFRYVPLDELLQVSD 205 Query: 206 VVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDV 265 + SLHVP P+T ++M + + MK GSLLIN +RG +VD +L AL LAGA +DV Sbjct: 206 IASLHVPYLPATHHLMNRETFARMKRGSLLINTARGGLVDTESLMWALDEGILAGAGLDV 265 Query: 266 FPTE------------PATNSDPFT----SPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 E PA L +NV++TPHI + EA I Sbjct: 266 LEGEELIQEESQLLTQPAVEDKLRAVLRQHLLARRENVVITPHIAFYSTEAVHRIMDVTI 325 Query: 310 GKLIKYSDNGSTLSAVNFPE 329 + + D G+ + V+ P Sbjct: 326 ENINAFLD-GNPQNVVSAPA 344 >UniRef50_Q8EP33 Glycerate dehydrogenase n=2 Tax=Bacillaceae RepID=Q8EP33_OCEIH Length = 314 Score = 335 bits (860), Expect = 2e-90, Method: Composition-based stats. Identities = 95/308 (30%), Positives = 147/308 (47%), Gaps = 11/308 (3%) Query: 21 QKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIG 80 +E+L G I ++ E+LK+++R+ I + + + +++I+AA L I Sbjct: 16 PDFVENLNRLGNVTILDTDNGIEKEKLKQAVREVEVI-ITAVVQIDKEIIDAAPNLKYIM 74 Query: 81 CFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWN 140 F G + +D A ++GIPV N P N +VA+L IG +L R +P N + G W Sbjct: 75 KFGAGYDNIDFKYAREKGIPVTNTPGQNADAVADLAIGLMLATARNIPAKNEELRNGNWE 134 Query: 141 KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA--TQVQHLS 198 + E KKLGIIG+G IG + A M V Y + + + L+ Sbjct: 135 --LSMGIEIFQKKLGIIGFGAIGQAIAQRATGFQMEVLAYGTFQDQTIADRLNVEFVDLN 192 Query: 199 DLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHL 258 LLN SD+V + ++ AK ++ +K +L IN SRG +VD AL +AL + + Sbjct: 193 KLLNESDIVVVSTTLRKDNYQLINAKTLNEIKKDALFINVSRGALVDEDALYEALTNGKI 252 Query: 259 AGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDN 318 GA +DVF EP PL N +TPHIG +T EA + G + + ++ Sbjct: 253 KGAGLDVFVEEP------SHHPLLTLPNTTVTPHIGAATNEAIKRTGSVALENVQRLKND 306 Query: 319 GSTLSAVN 326 L VN Sbjct: 307 LPLLYVVN 314 >UniRef50_A8IH65 D-isomer specific 2-hydroxyacid dehydrogenase n=3 Tax=Proteobacteria RepID=A8IH65_AZOC5 Length = 325 Score = 335 bits (860), Expect = 2e-90, Method: Composition-based stats. Identities = 102/313 (32%), Positives = 149/313 (47%), Gaps = 9/313 (2%) Query: 13 FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRD--AHFIGLRSRTHLTEDVI 70 + + + + AG + L + I +R + DV+ Sbjct: 6 VSVGGPLAPEGEALIVKAGGRVVSTAPYPA-RADLIALLASEQPDAIVVRVVEKIDADVM 64 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A+ +L I GTN +D++AAA G+PV A +N SVAE + LL L + + Sbjct: 65 RASPRLKLIAKHGAGTNDIDVEAAAALGLPVIAAVGANAHSVAEHALALLLALAKDIRTQ 124 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL-- 188 +A G W K FE RG+ LG++G G IG + + LGM V+ YD Sbjct: 125 DAFVRGGGWEKRVYKGFELRGRTLGLVGLGMIGRSFAAMVQPLGMTVFGYDPFAAPEAFG 184 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + +V L D+L DV+SLH P P T+ ++ A+ + LMKPGSLLIN +RG VVD A Sbjct: 185 PHVERVADLDDMLGRCDVISLHCPLTPQTEGLINARALGLMKPGSLLINTARGEVVDEEA 244 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L AL + L GA +D F EP + T PL NV+L+PHIGG T++A+ + Sbjct: 245 LVAALKNGPLGGAGLDSFAHEPPSP----THPLWSLPNVILSPHIGGVTEDARRQVSTMT 300 Query: 309 AGKLIKYSDNGST 321 A + + Sbjct: 301 ATNVAALMTGETI 313 >UniRef50_B8FRA5 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=78 Tax=Firmicutes RepID=B8FRA5_DESHD Length = 337 Score = 335 bits (860), Expect = 2e-90, Method: Composition-based stats. Identities = 86/325 (26%), Positives = 139/325 (42%), Gaps = 11/325 (3%) Query: 7 EKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLT 66 + K K L+ V Q+ E + + G + +L + + D + + +R + Sbjct: 10 DGSKPKVLIARQVPQEVEEWIGRHCEYSKWEGSGDIPRSELLKQLGDVDGLLI-NREKID 68 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 ++++AA KL + +G N D+ R + + P +VA+LV G +L R Sbjct: 69 GELLDAAPKLKIVANISVGYNNFDIGEMQARKVLGTHTPNVLDDTVADLVFGLMLSTARR 128 Query: 127 VPEANAKAHRGVWNKLAAG---SFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDI 182 + E + G WN+ + + LGIIG G IG L + M + +++ Sbjct: 129 LCELDRYVKAGRWNETVTPDLFGMDVHHQTLGIIGMGRIGRALAQRGKWGFDMNILYHNR 188 Query: 183 ENKLPLGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 + L +LL SD V L P +P T N+M +E LMK ++ I+ASR Sbjct: 189 SRHPEAEQRFDARYCTLEELLQRSDFVVLLAPLSPQTVNLMSGREFGLMKRSAVFISASR 248 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G VD AL +AL + GA +DV+ EP P PL F NV+ PH+G +T Sbjct: 249 GETVDEEALVEALREGRILGAGLDVYRKEPI----PPDHPLLRFKNVVTLPHLGSATTRT 304 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAV 325 + + A L+ V Sbjct: 305 RLAMARMAAENLLIGLKREIPPQCV 329 >UniRef50_Q8XPB1 D-3-phosphoglycerate dehydrogenase n=9 Tax=Clostridium perfringens RepID=Q8XPB1_CLOPE Length = 301 Score = 335 bits (859), Expect = 2e-90, Method: Composition-based stats. Identities = 101/305 (33%), Positives = 163/305 (53%), Gaps = 14/305 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 ++ LL +G+ +KA+ +L G+ + D E LKE I+ I +RS T + ++I Sbjct: 2 LRILLNDGLDKKAISNLEFLGF---DVDTNHYDIEDLKEKIKKVDCIVIRSATKIRRELI 58 Query: 71 NAA---EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 + A KL I +G + +D+ A + GI V N P +++ SVAE+++ + L R + Sbjct: 59 DEAIKGGKLKLIIRGGVGVDNIDVQYAEQNGIKVRNTPNASSSSVAEIILAHMFSLARFL 118 Query: 128 PEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP 187 ++N G+W K E GK LGIIG G IG++L +LGM + ++D+ + Sbjct: 119 NQSNITMKAGLWKKKDYVGVELEGKTLGIIGMGRIGSELAKKCTALGMKIIYFDLMDIKN 178 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + N + +LL SD +S+++ TK+++G++E+ +K G +IN SRG +D Sbjct: 179 IDNNYRKVEFDELLRESDFISINI---SGTKSIIGSEELKKVKKGVFIINTSRGKALDEE 235 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 A+ +L L G +DVF EP+ N + L V LTPHIG ST+EAQ IG E Sbjct: 236 AIITSLNDGTLGGVGLDVFLEEPSKNLE-----LINHPKVSLTPHIGASTKEAQMKIGEE 290 Query: 308 VAGKL 312 V + Sbjct: 291 VINII 295 >UniRef50_A7BQE7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Beggiatoa sp. PS RepID=A7BQE7_9GAMM Length = 302 Score = 335 bits (859), Expect = 2e-90, Method: Composition-based stats. Identities = 111/311 (35%), Positives = 160/311 (51%), Gaps = 13/311 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K LLVE ++ +A+ +LR+ +E E+L E I D + L+SR L ++ I Sbjct: 1 MKILLVEPIYCEAIIALRSKFELFVEILPN---KERLLEVIEDKDVVILKSRIELDKEAI 57 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA+ L + IG + + LD KRGI FN P + R VAELV+G L L R + Sbjct: 58 FAAKHLKLVVMAGIGLDHICLDELKKRGIAWFNIPDLSARGVAELVLGLTLSLARKICLG 117 Query: 131 NAKAHRGV---WNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI-ENKL 186 ++ W + F + + GI+GYG IG ++ +A+ GM V Y + Sbjct: 118 DSLLRNNEFKLWKRPELMGFNLQDRLFGIVGYGKIGKEMASVAKCFGMKVQVYVRNSDHK 177 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 +LL SDV+S+HVP TK M E LM+ +LLIN SRG VV+ Sbjct: 178 TFEQNITPVTFQNLLKTSDVISIHVPLTDETKGMFSKPEFELMQETALLINTSRGGVVNE 237 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 L AL SK + GAA+DVF + +S L E DN+++TPHIG TQE QE IGL Sbjct: 238 KDLYHALKSKIIGGAALDVFEQKKPDDS------LFELDNIVVTPHIGAMTQETQEQIGL 291 Query: 307 EVAGKLIKYSD 317 ++ K+ ++ Sbjct: 292 QIVKKIFEFFK 302 >UniRef50_Q59516 Glycerate dehydrogenase n=35 Tax=Proteobacteria RepID=DHGY_METEA Length = 314 Score = 335 bits (859), Expect = 2e-90, Method: Composition-based stats. Identities = 86/298 (28%), Positives = 142/298 (47%), Gaps = 16/298 (5%) Query: 34 NIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDA 93 + ++ E++ E ++ A + ++ + D + L I GT+ VD A Sbjct: 25 EYKEYESTWTPEEIVERLQGAEIAMI-NKVPMRADTLKQLPDLKLIAVAATGTDVVDKAA 83 Query: 94 AAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSF------ 147 A +GI V N +V E V+G + L R + RG WNK + Sbjct: 84 AKAQGITVVNIRNYAFNTVPEHVVGLMFALRRAIVPYANSVRRGDWNKSKQFCYFDYPIY 143 Query: 148 EARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLLNMSDVV 207 + G LGIIGYG +G + AE+LGM V +D+ + + L +L SDV+ Sbjct: 144 DIAGSTLGIIGYGALGKSIAKRAEALGMKVLAFDVFPQD------GLVDLETILTQSDVI 197 Query: 208 SLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFP 267 +LHVP P TKNM+GA+++ MK ++LIN +RG +VD AL AL + GA DV Sbjct: 198 TLHVPLTPDTKNMIGAEQLKKMKRSAILINTARGGLVDEAALLQALKDGTIGGAGFDVVA 257 Query: 268 TEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAV 325 EP + + + N+++TPH+ +++EA + + ++ + + G + V Sbjct: 258 QEPPKDGNILCD--ADLPNLIVTPHVAWASKEAMQILADQLVDNVEAFVA-GKPQNVV 312 >UniRef50_A4EAR0 Putative uncharacterized protein n=3 Tax=Bacteria RepID=A4EAR0_9ACTN Length = 387 Score = 335 bits (859), Expect = 3e-90, Method: Composition-based stats. Identities = 107/380 (28%), Positives = 181/380 (47%), Gaps = 32/380 (8%) Query: 46 QLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAP 105 + + +A I +RS ++ + AI G N + ++ AK+G+ VFN+P Sbjct: 23 EFVSTAEEADAILMRSTDLHGYELPEG---IRAIARCGAGVNNIPVEEYAKKGVVVFNSP 79 Query: 106 FSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWN----------KLAAGSFEARGKKLG 155 +N+ +V ELV+G L+L RGV ++ + K A E +GK++G Sbjct: 80 GANSNAVKELVLGMLVLSSRGVVQSMNWVRDNADDPEIQVDAEKAKKAFVGRELKGKRIG 139 Query: 156 IIGYGHIGTQLGILAESLGMYVYFYDI----ENKLPLGNATQ-VQHLSDLLNMSDVVSLH 210 +IG G++G+++ LGM VY YD E+ L Q V L DL D +++H Sbjct: 140 VIGLGNVGSKVANACVDLGMDVYGYDPFISVEHAWVLSREVQRVGTLEDLCRGCDYLTVH 199 Query: 211 VPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEP 270 VP T M+ ++I+L+ P ++LIN +R T++D A+ AL L+ + D F T P Sbjct: 200 VPSKADTIGMISTEQINLLAPDAVLINYARETIIDEDAVDAALREGKLSWFSCD-FAT-P 257 Query: 271 ATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEV 330 T + N +T H G T EA+ N +L Y +NG+ +VN+P Sbjct: 258 KT---------VKMPNTFITTHSGAGTGEAEANCADMAISELKDYLENGNIAHSVNYPAC 308 Query: 331 SL-PLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDV 389 S+ R+ +H N P ++ + I A+ N+ +++ + Y + D DE + Sbjct: 309 SMGKARAASRIACLHANVPNMIGQITAILAKDNANVQRMTNESAGENAYTMFD--TDEHL 366 Query: 390 AEKALQAMKAIPGTIRARLL 409 ++A+K IP R R++ Sbjct: 367 DSSTIEALKQIPSMYRVRVI 386 >UniRef50_Q4PK14 Predicted D-isomer specific 2-hydroxyacid dehydrogenase family protein n=1 Tax=uncultured bacterium MedeBAC49C08 RepID=Q4PK14_9BACT Length = 395 Score = 334 bits (858), Expect = 3e-90, Method: Composition-based stats. Identities = 110/416 (26%), Positives = 194/416 (46%), Gaps = 44/416 (10%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K + + K L+ L+ GY A+ +E+ + I LRS ++ + Sbjct: 4 KVKTINNISDKGLDILKNKGY--------AVGEEE-----SEPDAIILRSHKLQMSEIPS 50 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 + + AI G N + ++ +K GIPVFN P +N +V E+V+ LL+ RG+ + Sbjct: 51 S---VKAIVRAGAGVNNIPVEECSKIGIPVFNTPGANANAVKEMVLAALLMSSRGIFDGV 107 Query: 132 AKAHRGVWN-------------KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVY 178 H G+ + K + E + LG++G G IG ++ + LGM V Sbjct: 108 KFVH-GIEDVSKENLKAHIESGKKSFKGRELKDGCLGVVGMGAIGAKVAEMGVMLGMRVI 166 Query: 179 FYDI----ENKLPLGNAT-QVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGS 233 +D E L N + + + ++ SD V+LHVP N T M+ + G Sbjct: 167 GFDPQITVEAAWALPNEVERKETIEEIFKESDYVTLHVPANEHTTGMINKDLLLHSNKGL 226 Query: 234 LLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHI 293 LIN +R +V+ A+ DAL + L D P ++++L PHI Sbjct: 227 RLINFARDEIVNSQAIIDALENDKLNKYVTD-------FADLPLIERSKSNEDIVLLPHI 279 Query: 294 GGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTA 353 G ST +A+EN + A ++I + ++G+ ++VN+P++ P+ RL ++N G++ Sbjct: 280 GASTMQAEENCSVMAANQIINFLEHGNIKNSVNYPQIIEPMETSYRLTIANKNVSGMIGK 339 Query: 354 LNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 + I AE+G+NI ++ + Y VID+ D + + K+++A+K I R + Sbjct: 340 ITAIIAEEGLNIIDMKNRSRDDIAYNVIDL--DSEPSTKSIEAIKGEENIINVRQI 393 >UniRef50_C8WP48 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=53 Tax=Bacteria RepID=C8WP48_EGGLE Length = 391 Score = 334 bits (858), Expect = 4e-90, Method: Composition-based stats. Identities = 108/386 (27%), Positives = 181/386 (46%), Gaps = 32/386 (8%) Query: 42 LDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPV 101 DD +L +++ A + +RS ++ L+AI G N + LD A+ GI V Sbjct: 19 TDDYELIDALDQAEGVLVRSAALHDTAFPDS---LLAIARAGAGVNNIPLDRCAEEGIVV 75 Query: 102 FNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNK----------LAAGSFEARG 151 FN P +N +V E+V+ L+L R + A ++ A E +G Sbjct: 76 FNTPGANANAVKEIVVCGLMLGSRDIAGGIAWCRHNADDENIAKAAEKAKKAFAGREVKG 135 Query: 152 KKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG-----NATQVQHLSDLLNMSDV 206 KKLG+IG G IG ++ +A LGM VY YD + V +L D+ Sbjct: 136 KKLGVIGLGAIGAEVANIAIDLGMDVYGYDPYVSVGAAWRISSAVHHVTNLDDIFRTCGY 195 Query: 207 VSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVF 266 +++HVP T M+ + SLMK G++ +N SR T+VD A+ AL S + D Sbjct: 196 MTIHVPAMDGTIGMIDERACSLMKDGAVFLNFSRDTLVDNAAMAAALDSGKVHAYITDFA 255 Query: 267 PTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVN 326 E + + + ++ PH+G ST EA++N + +L+ Y +NG+ ++VN Sbjct: 256 TPE-----------VMKMERAIVLPHLGASTAEAEDNCAMMAVRELMDYLENGNIANSVN 304 Query: 327 FPEVSLP--LHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIE 384 +P + G RR+ +H N P + + +F + GVNI + + Y ++D++ Sbjct: 305 YPACDMGPVPDGLRRVAVLHANVPNAIARITNVFGDAGVNIENMMNKARGENAYTMLDLD 364 Query: 385 A-DEDVAEKALQAMKAIPGTIRARLL 409 A + A++ + AI G R R++ Sbjct: 365 AGTPGHPDDAIERLSAIEGVRRVRVV 390 >UniRef50_Q01ZI8 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=3 Tax=Bacteria RepID=Q01ZI8_SOLUE Length = 400 Score = 334 bits (858), Expect = 4e-90, Method: Composition-based stats. Identities = 118/390 (30%), Positives = 180/390 (46%), Gaps = 18/390 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDA--HFIGLRSRTHLTED 68 ++ L+ + Q E L A G L DE L + + +RS T + E Sbjct: 1 MRILIADEFEQSGREQLNALGCEV--RFAPKLKDEALVAEVDSFRPDVLVVRS-TKVPEA 57 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 V+ AA L + G N +D+ AA++RGI V N P N+ +VAEL G +L L R + Sbjct: 58 VL-AAGALKLVVRAGAGHNTIDVGAASRRGIYVSNCPGKNSVAVAELAFGLILALDRQIA 116 Query: 129 EANAKAHRGVWNKLAAG-SFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP 187 + G WNK + G+ LG+IG G IG ++ A + G+ V + Sbjct: 117 DNVIALREGRWNKSGFSKARGLFGRTLGLIGVGQIGREMIPRARAFGLPVVAWSRSLTPE 176 Query: 188 LGNATQVQ---HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 A V+ +++ +D+VS+HV NP TK M+ A+ I+ ++PG+ IN SR VV Sbjct: 177 SAKALGVEYKPSPAEVAAAADIVSVHVALNPQTKGMLNAEWIAALRPGAYFINTSRAEVV 236 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL A+ K + A +DVF EPA + F + + + V T HIG ST++AQE I Sbjct: 237 DQEALSRAVTEKGIR-AGLDVFAKEPAGGAGDFADEIVKLNGVYGTHHIGASTEQAQEAI 295 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVN 364 E + + G + VN + L+ H +RPGVL A+ G+N Sbjct: 296 AAETVRIIRTFLQTGKVPNVVNLARTTPATCA---LVVRHLDRPGVLAAVLDSVRAAGIN 352 Query: 365 IAAQYL----QTSAQMGYVVIDIEADEDVA 390 + A + + ++ DEDV Sbjct: 353 VQEMENIIFEGAEAAVARIHLETVPDEDVL 382 >UniRef50_C4V5E1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Selenomonas flueggei ATCC 43531 RepID=C4V5E1_9FIRM Length = 334 Score = 334 bits (857), Expect = 4e-90, Method: Composition-based stats. Identities = 85/322 (26%), Positives = 144/322 (44%), Gaps = 15/322 (4%) Query: 12 KFLLVE----GVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 K + + + + E L AG T I ++ + + DA + L +T Sbjct: 3 KIYVTDYEYDSLAPEEHE-LARAGLTLIPQQCH--TEDDVIRTCADASGL-LNQYAPITR 58 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 VI A L I + +G N VDL+AA + G+ V N P V+ L+ R + Sbjct: 59 RVIEALPHLKVIARYGVGVNTVDLEAATEHGVCVLNVPDYCADEVSNHAFALLMACHRKL 118 Query: 128 PEANAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--EN 184 + + + G W+ + G+ LG++G+G I L A + G+ YD Sbjct: 119 APLHTQVNGGGWDYNICKPIHRLAGQTLGLLGFGRIPRLLAEKARAFGLKFAVYDPFVTP 178 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + ++ L ++L SD++S+HVP T++++ +E +MKP ++LIN SRG ++ Sbjct: 179 AIVASYGGKLLTLGEVLQASDMISVHVPLTKETEHLLSHREFDMMKPSTILINTSRGPLI 238 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL AL +A A +DV EP SPL N+++TPH ++EA+ + Sbjct: 239 DEEALYAALTQGKIAAAGLDVTEQEPLAQD----SPLRSLPNIIITPHAAWYSEEAECEL 294 Query: 305 GLEVAGKLIKYSDNGSTLSAVN 326 + A + + VN Sbjct: 295 KTKAARGIADILSGHDLPNIVN 316 >UniRef50_C6PW23 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Clostridium carboxidivorans P7 RepID=C6PW23_9CLOT Length = 346 Score = 334 bits (857), Expect = 4e-90, Method: Composition-based stats. Identities = 99/313 (31%), Positives = 159/313 (50%), Gaps = 12/313 (3%) Query: 24 LESLRAAGYTNIEFHKGALD-DEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCF 82 LE L+ + A++ ++L E I + + ++ +++ +I+ A+KL IG Sbjct: 40 LEMLQKDNLLVEQNGPDAVEFSQELIEDISEYDILIVQ-FAPISKKIIDKAKKLKIIGVL 98 Query: 83 CIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKL 142 G + + AA +GI V N P N R+VAE +G +L +R + ++A +G W K Sbjct: 99 RGGVENIAYEYAAIKGITVMNTPGRNARAVAEFAMGMILSEVRNIARSHAALKKGEWRKK 158 Query: 143 AAGS---FEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSD 199 + E K +GI+G+G IG + ++ G V YD + + L Sbjct: 159 FPNTGDIPELCNKTVGIVGFGSIGQLVAGYLKAFGCNVIAYDPFFNGNF-DGVNIVELPY 217 Query: 200 LLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLA 259 LL SDV+++H T +++G KEISLMKP ++L+N +R +VD AL +AL ++ Sbjct: 218 LLKNSDVITVHARLTEDTYHLIGGKEISLMKPNAVLVNTARSGLVDEKALKEALEEGKIS 277 Query: 260 GAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNG 319 GAA+DVF EP +D L + DNV +TPH+ GST++A N + LI+ Sbjct: 278 GAALDVFDVEPLEENDI----LMKLDNVTITPHVAGSTKDAFTNSPKLMRDILIRTIKGE 333 Query: 320 STLSAVNF--PEV 330 L VN PE+ Sbjct: 334 KRLPIVNGIKPEI 346 >UniRef50_Q65WI5 SerA protein n=1 Tax=Mannheimia succiniciproducens MBEL55E RepID=Q65WI5_MANSM Length = 326 Score = 334 bits (857), Expect = 5e-90, Method: Composition-based stats. Identities = 93/328 (28%), Positives = 159/328 (48%), Gaps = 11/328 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K ++ +H ++ L A + G + + + + DA + +R + + + + Sbjct: 3 MKVVISHRLHDNGMKVLEDANAQVAITNDG--NPKIMLPELLDAEGLIIRIGS-IDRETM 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A+ L IG +G + VD+ A + GIPV AP SNTRSVAE + + + + Sbjct: 60 LQAKNLKVIGRPGVGVDDVDVKTATELGIPVVIAPGSNTRSVAEHAFALMFACAKDIVRS 119 Query: 131 NAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK---L 186 + + +G + + + ++E K L +IGYG IG+ L +++++GM V YD K + Sbjct: 120 DNEMRKGNFAIRSSYKAYELNHKTLALIGYGRIGSILAQMSKAIGMNVKVYDPFVKQGTI 179 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 L D++ S V+S+HVP T+N++G E SLM ++LIN +RG V+D Sbjct: 180 EQEGYIYCTELDDVIRDSHVISIHVPLTNETRNLIGEHEFSLMNEHTILINCARGEVIDE 239 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 P L L + A +DVF EP SPL + DNV+++PH+ G T+EA + Sbjct: 240 PVLTKVLQEGKIHSAGLDVFACEPVD----INSPLFQLDNVIVSPHMAGQTKEAASGVAT 295 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEVSLPL 334 A ++ + N + P Sbjct: 296 MAAEGVVAVINGEKWPYVCNPEAYNHPR 323 >UniRef50_Q5WAF3 2-ketogluconate reductase n=2 Tax=Bacteria RepID=Q5WAF3_BACSK Length = 321 Score = 334 bits (857), Expect = 5e-90, Method: Composition-based stats. Identities = 94/323 (29%), Positives = 151/323 (46%), Gaps = 12/323 (3%) Query: 9 DKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 K L + AL + + I L E L + D L T + Sbjct: 2 SKPTVFLARSLPDAALNHISQFCHLRIWDESKPLTREALAHELADVDGAMLTGIGADT-E 60 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 ++ A KL I +G + D+ A++ I V N P+ +VA+L+ G +L R + Sbjct: 61 LVKHASKLKVISTATVGYDGFDVAGLAEQNIYVTNTPYVLDETVADLLFGLILSGARRIA 120 Query: 129 EANAKAHRGVWNKL----AAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIE 183 + + G W K + + + LGI+G G IG ++ A+ GM + +++ Sbjct: 121 PLHEQVKAGNWTKQTTAQSLYGQDVYNQTLGIVGMGRIGEKIVHRAKEGFGMKILYHNRS 180 Query: 184 NKLPLGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 ++ + + L +LL +DVV + VP +TK+++G +E+S MK ++L+N +RG Sbjct: 181 SRPEVEKKYGAKKVELHELLEQADVVVIMVPLTEATKHLIGKEELSKMKETAILVNGARG 240 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 V+D AL +AL K + GAA+DVF EP P PL E DNV LTPHIG +T + Sbjct: 241 AVIDEAALIEALKQKTIFGAALDVFEVEPL----PPGHPLLELDNVTLTPHIGSATAATR 296 Query: 302 ENIGLEVAGKLIKYSDNGSTLSA 324 E + L A L+ + A Sbjct: 297 EAMALRAAENLVAGALGQKPRDA 319 >UniRef50_Q1MPI0 Lactate dehydrogenase and related dehydrogenases n=2 Tax=Desulfovibrionaceae RepID=Q1MPI0_LAWIP Length = 323 Score = 333 bits (856), Expect = 5e-90, Method: Composition-based stats. Identities = 99/312 (31%), Positives = 134/312 (42%), Gaps = 15/312 (4%) Query: 21 QKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIG 80 L A G + EQ E +DA + + R LT + I KL IG Sbjct: 15 DNPWTPLEALGKLTVY---DLTKPEQTVERAKDADILLV-GRDILTTEHIEELPKLKCIG 70 Query: 81 CFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRG--- 137 G NQ+D++ A KRGIPV N +VA+ LL L R + G Sbjct: 71 VLGTGYNQIDIETAGKRGIPVINVTAYGVDAVAQHAFALLLELCRHTAALDQAIRNGAWS 130 Query: 138 --VWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN-KLPLGNATQV 194 W E K GIIGYG+IG + G +A M V YD + P Sbjct: 131 SPDWAPWKYPQVELTYKCFGIIGYGNIGQKAGYIAHGFDMSVLAYDERPVQPPSYTPFSF 190 Query: 195 QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALA 254 L ++ +DV+SLH P +++ K I MK G+++IN +RG ++D A+ DAL Sbjct: 191 ADLDEVFKNADVLSLHCPLTEDNFHLVNKKRIETMKDGAIIINVARGALLDEQAVADALI 250 Query: 255 SKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIK 314 S L G D F EP +PL N + TPHI + EA+ NI +A L Sbjct: 251 SGKLGGLGSDAFVDEPIN----LNNPLLSAPNTVFTPHIAWESVEARRNIVRILAENLKA 306 Query: 315 YSDNGSTLSAVN 326 + D G S VN Sbjct: 307 WMD-GKPQSVVN 317 >UniRef50_C2BTH2 D-3-phosphoglycerate dehydrogenase n=1 Tax=Mobiluncus curtisii ATCC 43063 RepID=C2BTH2_9ACTO Length = 324 Score = 333 bits (856), Expect = 6e-90, Method: Composition-based stats. Identities = 94/302 (31%), Positives = 142/302 (47%), Gaps = 8/302 (2%) Query: 23 ALESLRAAGYTNIEFHKGA-LDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGC 81 A + L +GY G LD +QL ++ RD + L + V+N L I Sbjct: 23 ARKLLEESGYEVTYNQSGKPLDADQLVKAARDCVGV-LAGLDDFSTPVLNQLPDLRVISR 81 Query: 82 FCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNK 141 + +G ++VDL A G+ V N P +N+ +VAE+ + + L R V + N RG W + Sbjct: 82 YGVGVDRVDLRTAGDNGVIVTNTPGANSTAVAEMALSSMFTLARHVSQLNETTRRGQWLR 141 Query: 142 LAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLL 201 + E LGI+GYG IG L L L M V YD Q L++L+ Sbjct: 142 VV--GTELSQATLGIVGYGSIGRALRRLVTGLEMKVLVYDPFFDPDTDPTVQGVELAELV 199 Query: 202 NMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGA 261 S+ +SLH+P P+T+++ LM PG+ LIN SRG ++D A AL + LAG Sbjct: 200 RESNFISLHLPLTPATEHLFDDSMFRLMSPGTFLINTSRGGIIDESAAVVALEAGQLAGL 259 Query: 262 AIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGST 321 A+D + EP + L F NV+ TPH G T +++ + L++ S Sbjct: 260 ALDAYEQEPPSPE----HELFRFSNVIATPHSGAQTVQSRIRMARGAVDNLLRALAGESV 315 Query: 322 LS 323 + Sbjct: 316 TN 317 >UniRef50_A7NGZ0 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Roseiflexus RepID=A7NGZ0_ROSCS Length = 345 Score = 333 bits (856), Expect = 6e-90, Method: Composition-based stats. Identities = 98/287 (34%), Positives = 140/287 (48%), Gaps = 13/287 (4%) Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A L+AI IG + +DL AA +RGI V N P T S AE + +L L + V A Sbjct: 65 RAGPTLMAIARPGIGVDNIDLAAATERGILVINTPDGPTESTAEHAVALVLALAKQVVAA 124 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYD---IENKL 186 + + W+ E RGK LG++G G IG ++ + LGM V YD Sbjct: 125 DHRFRTAGWSAARLRGVEVRGKTLGVVGLGRIGRRVAQICRQGLGMRVAAYDPLAPAEAF 184 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + V+ L +LL S+ ++LH PST+ ++GA+E++L+ G+ LIN SRG V+D Sbjct: 185 AALDVVHVETLDNLLPQSEFLTLHCALTPSTRGLIGARELALLPKGAFLINVSRGAVIDQ 244 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL DAL + HLAGA +DVF EP P PL +F +V+LTPHI T + + Sbjct: 245 AALIDALTTGHLAGAGLDVFDPEPL----PNDHPLLQFPHVILTPHIASFTDDGVRVMHH 300 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTA 353 ++++ VN GRR H +P L Sbjct: 301 GAVAQIVRLLRGEHPPHIVN-----PEALPGRRAKMNHGTQPDALPT 342 >UniRef50_Q03WU1 Lactate dehydrogenase related dehydrogenase n=3 Tax=Leuconostoc mesenteroides RepID=Q03WU1_LEUMM Length = 312 Score = 333 bits (855), Expect = 7e-90, Method: Composition-based stats. Identities = 88/317 (27%), Positives = 150/317 (47%), Gaps = 11/317 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + +V +H+ A++ +AGY H D+++L DA I + ++ + Sbjct: 5 RIHIVGDLHEVAIQKFTSAGYDV--SHSPNYDEKKLLSLASDAAVIIMT-DMAFDKNWFD 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A L I +G + + +++A K G+ V N P +N +VAEL + +L +LR V +A Sbjct: 62 ALPNLKLIARRGVGYDNIPVESATKHGVWVTNTPGANAIAVAELAVTLILTVLRKVNQAT 121 Query: 132 AKAHRGVW--NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 +G + GK +G+IGYG I L + G +V Y + L Sbjct: 122 NSVQKGEALTYPASLMGHNLSGKIIGLIGYGQIAQNLEKILHGFGAHVLVYSRTKRETLY 181 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 Q LL SD++SLH+P P T ++ + S MK ++LIN +R +VD AL Sbjct: 182 G--QFVSYDTLLAQSDIISLHIPATPETSGILNHEAFSKMKTNAILINTARAALVDEEAL 239 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 +A+ + +AGA +D E SPL D +++TPHIG +T E++ +V Sbjct: 240 VEAINTGKIAGAGLDTTSYETIKT----ASPLLNHDQIVITPHIGANTVESEYLTAEKVV 295 Query: 310 GKLIKYSDNGSTLSAVN 326 ++ + +N + +N Sbjct: 296 ASVLDFFNNQKPIYRLN 312 >UniRef50_C3WAJ0 D-isomer specific 2-hydroxyacid dehydrogenase n=1 Tax=Fusobacterium mortiferum ATCC 9817 RepID=C3WAJ0_FUSMR Length = 313 Score = 333 bits (855), Expect = 8e-90, Method: Composition-based stats. Identities = 91/325 (28%), Positives = 150/325 (46%), Gaps = 23/325 (7%) Query: 11 IKFLLVEGVHQKA----LESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLT 66 +K ++++G + E L+ G I +E + E +DA I + ++ Sbjct: 1 MKIVVLDGYTENPGDLSWEWLKKYGEVEIYDRTP---EELVYERSKDAEVI-ITNKVPFN 56 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 + + KL IG G N +D++A ++ I V N P ++ VA++V LL + Sbjct: 57 RERVERLPKLKYIGITAAGYNIIDIEAVKEKNIIVTNTPNYGSKVVAQMVFAHLLEITNN 116 Query: 127 VPEANAKAHRGVWNKLAAGSF------EARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 V + G W++ + GK +GI+GYG+IG ++ +A GM + Y Sbjct: 117 VGLHSKSVKDGEWSEKLDFCYWKKPIISLEGKTIGILGYGNIGKEVEKIALVFGMKILIY 176 Query: 181 DIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 D +N N L ++L SDV+SLH+P T ++ + I MK +LIN SR Sbjct: 177 DRKN----LNIDNQVTLEEILKRSDVISLHLPLTEETYRLVNKETIKKMKKDVILINTSR 232 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G +VD L +A+ S + G DV EP S L + D + +TPHI + EA Sbjct: 233 GPLVDETDLLEAIKSGKIYGVGFDVLKNEPPQKD----SELLKNDRINITPHIAWAAIEA 288 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAV 325 ++NI L Y NG ++++ Sbjct: 289 RQNIMKIAEENLKNYL-NGKVINSI 312 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_P43885 D-3-phosphoglycerate dehydrogenase n=399 Tax=Bac... 485 e-135 UniRef50_D2RHI0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Archa... 479 e-133 UniRef50_O27051 D-3-phosphoglycerate dehydrogenase n=16 Tax=Arch... 468 e-130 UniRef50_C6W4R7 HAD-superfamily hydrolase, subfamily IB (PSPase-... 466 e-130 UniRef50_A1W4D0 D-3-phosphoglycerate dehydrogenase n=26 Tax=cell... 465 e-129 UniRef50_O29445 D-3-phosphoglycerate dehydrogenase n=8 Tax=cellu... 462 e-129 UniRef50_Q1AXS3 D-3-phosphoglycerate dehydrogenase n=2 Tax=Actin... 462 e-128 UniRef50_A5D6D4 Phosphoglycerate dehydrogenase and related dehyd... 462 e-128 UniRef50_B8HPZ0 D-3-phosphoglycerate dehydrogenase n=26 Tax=cell... 458 e-127 UniRef50_C8WVY8 D-3-phosphoglycerate dehydrogenase n=2 Tax=Alicy... 458 e-127 UniRef50_C6HZG9 D-3-phosphoglycerate dehydrogenase n=1 Tax=Lepto... 457 e-127 UniRef50_P40054 D-3-phosphoglycerate dehydrogenase 1 n=76 Tax=ce... 455 e-126 UniRef50_A9EWF7 Phosphoglycerate dehydrogenase n=17 Tax=cellular... 454 e-126 UniRef50_C5DTI9 ZYRO0C08932p n=1 Tax=Zygosaccharomyces rouxii Re... 454 e-126 UniRef50_Q11WE3 Phosphoserine phosphatase and phosphoglycerate d... 451 e-125 UniRef50_D2VJX3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Naegl... 449 e-124 UniRef50_B4D991 D-3-phosphoglycerate dehydrogenase n=3 Tax=Verru... 448 e-124 UniRef50_B0TAQ8 D-3-phosphoglycerate dehydrogenase n=4 Tax=Clost... 446 e-124 UniRef50_A0LMX1 D-3-phosphoglycerate dehydrogenase n=1 Tax=Syntr... 445 e-124 UniRef50_A1RYE4 Glyoxylate reductase n=18 Tax=cellular organisms... 444 e-123 UniRef50_A3UGW9 D-3-phosphoglycerate dehydrogenase n=2 Tax=Alpha... 442 e-122 UniRef50_A5G1V9 D-3-phosphoglycerate dehydrogenase n=3 Tax=Prote... 442 e-122 UniRef50_Q2G4V7 D-3-phosphoglycerate dehydrogenase n=146 Tax=cel... 441 e-122 UniRef50_D1JIG3 D-3-phosphoglycerate dehydrogenase n=1 Tax=uncul... 439 e-121 UniRef50_A2STQ1 D-3-phosphoglycerate dehydrogenase n=5 Tax=cellu... 437 e-121 UniRef50_A5FRL7 D-3-phosphoglycerate dehydrogenase n=5 Tax=Dehal... 436 e-121 UniRef50_A9WCW3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chlor... 435 e-120 UniRef50_B8CX87 D-3-phosphoglycerate dehydrogenase n=1 Tax=Halot... 435 e-120 UniRef50_A7IAB7 D-3-phosphoglycerate dehydrogenase n=11 Tax=cell... 435 e-120 UniRef50_A6UQN3 D-3-phosphoglycerate dehydrogenase n=4 Tax=Eurya... 435 e-120 UniRef50_UPI0001C41AB7 phosphoglycerate dehydrogenase SerA n=1 T... 434 e-120 UniRef50_Q1PZY1 Similar to D-3-phosphoglycerate dehydrogenase (P... 434 e-120 UniRef50_B3DVF6 Phosphoglycerate dehydrogenase and ACT domains n... 434 e-120 UniRef50_C4V410 Phosphoglycerate dehydrogenase n=4 Tax=Veillonel... 432 e-120 UniRef50_P35136 D-3-phosphoglycerate dehydrogenase n=12 Tax=Baci... 432 e-119 UniRef50_Q1CYP3 D-3-phosphoglycerate dehydrogenase n=5 Tax=cellu... 431 e-119 UniRef50_UPI0001C430A3 D-3-phosphoglycerate dehydrogenase n=1 Ta... 431 e-119 UniRef50_P73821 D-3-phosphoglycerate dehydrogenase n=40 Tax=Cyan... 431 e-119 UniRef50_A7HM61 Glyoxylate reductase n=6 Tax=cellular organisms ... 430 e-119 UniRef50_B2V7I1 D-3-phosphoglycerate dehydrogenase n=8 Tax=Aquif... 430 e-119 UniRef50_Q1IVI0 D-3-phosphoglycerate dehydrogenase n=3 Tax=Acido... 430 e-119 UniRef50_D1FX73 3-phosphoglycerate dehydrogenase-like protein n=... 429 e-119 UniRef50_Q67TJ9 Phosphoglycerate dehydrogenase n=1 Tax=Symbiobac... 429 e-119 UniRef50_A3DM01 D-isomer specific 2-hydroxyacid dehydrogenase, N... 429 e-118 UniRef50_A7HDB1 D-3-phosphoglycerate dehydrogenase n=3 Tax=Prote... 429 e-118 UniRef50_Q5WGX7 D-3-phosphoglycerate dehydrogenase n=8 Tax=Bacil... 429 e-118 UniRef50_C7R3H8 D-isomer specific 2-hydroxyacid dehydrogenase NA... 429 e-118 UniRef50_O43175 D-3-phosphoglycerate dehydrogenase n=53 Tax=Bila... 429 e-118 UniRef50_B7KZ64 D-3-phosphoglycerate dehydrogenase n=16 Tax=cell... 428 e-118 UniRef50_B6YWH0 Glyoxylate reductase n=95 Tax=cellular organisms... 427 e-118 UniRef50_A6C9V4 Phosphoglycerate dehydrogenase n=1 Tax=Planctomy... 427 e-118 UniRef50_A8ZXY9 D-3-phosphoglycerate dehydrogenase n=6 Tax=Delta... 426 e-118 UniRef50_B5JEX5 D-3-phosphoglycerate dehydrogenase n=2 Tax=Verru... 424 e-117 UniRef50_B9L167 Phosphoglycerate dehydrogenase SerA n=2 Tax=Ther... 424 e-117 UniRef50_D0NEX4 D-3-phosphoglycerate dehydrogenase n=1 Tax=Phyto... 424 e-117 UniRef50_B2IJN8 D-3-phosphoglycerate dehydrogenase n=6 Tax=Bacte... 424 e-117 UniRef50_B3RTC6 Putative uncharacterized protein n=1 Tax=Trichop... 422 e-117 UniRef50_C1TPS0 Lactate dehydrogenase-like oxidoreductase n=1 Ta... 422 e-117 UniRef50_B1HVJ4 Phosphoglycerate dehydrogenase n=5 Tax=Bacillale... 422 e-116 UniRef50_C0QYX0 D-3-phosphoglycerate dehydrogenase n=2 Tax=Brach... 421 e-116 UniRef50_O04130 D-3-phosphoglycerate dehydrogenase, chloroplasti... 420 e-116 UniRef50_Q49YF7 D-3-phosphoglycerate dehydrogenase n=55 Tax=Baci... 419 e-115 UniRef50_Q4L766 D-3-phosphoglycerate dehydrogenase n=3 Tax=Staph... 417 e-115 UniRef50_C1ZMC1 D-3-phosphoglycerate dehydrogenase n=2 Tax=Planc... 416 e-115 UniRef50_C6PIV3 D-isomer specific 2-hydroxyacid dehydrogenase NA... 416 e-115 UniRef50_B6KF90 D-3-phosphoglycerate dehydrogenase, putative n=3... 416 e-115 UniRef50_C1SGT4 D-3-phosphoglycerate dehydrogenase n=1 Tax=Denit... 415 e-114 UniRef50_UPI0001C31769 D-3-phosphoglycerate dehydrogenase n=1 Ta... 415 e-114 UniRef50_A5IMH3 D-isomer specific 2-hydroxyacid dehydrogenase, N... 413 e-114 UniRef50_A5GES6 D-3-phosphoglycerate dehydrogenase n=12 Tax=Desu... 413 e-114 UniRef50_UPI0000DB72A4 PREDICTED: similar to 3-phosphoglycerate ... 412 e-113 UniRef50_C9LMC8 Phosphoglycerate dehydrogenase n=1 Tax=Dialister... 411 e-113 UniRef50_B5YAK7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Dicty... 410 e-113 UniRef50_B7P3M8 D-3-phosphoglycerate dehydrogenase, putative (Fr... 409 e-112 UniRef50_C2BW43 Phosphoglycerate dehydrogenase n=1 Tax=Mobiluncu... 409 e-112 UniRef50_D2RMS7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acida... 408 e-112 UniRef50_C8WI96 D-3-phosphoglycerate dehydrogenase n=1 Tax=Egger... 408 e-112 UniRef50_B0K2Z0 D-isomer specific 2-hydroxyacid dehydrogenase, N... 407 e-112 UniRef50_B6H0R3 Pc12g10550 protein n=23 Tax=Fungi/Metazoa group ... 407 e-112 UniRef50_Q0B0Y6 D-3-phosphoglycerate dehydrogenase n=9 Tax=Bacte... 407 e-112 UniRef50_B4AUS0 Glyoxylate reductase n=1 Tax=Cyanothece sp. PCC ... 406 e-112 UniRef50_Q7UQL2 Phosphoglycerate dehydrogenase n=1 Tax=Rhodopire... 406 e-111 UniRef50_Q2RH37 D-isomer specific 2-hydroxyacid dehydrogenase, N... 405 e-111 UniRef50_D0MG73 Glyoxylate reductase n=1 Tax=Rhodothermus marinu... 405 e-111 UniRef50_D2R855 D-3-phosphoglycerate dehydrogenase n=1 Tax=Pirel... 404 e-111 UniRef50_A1HQU2 Glyoxylate reductase n=1 Tax=Thermosinus carboxy... 403 e-111 UniRef50_Q5SZU1 Phosphoglycerate dehydrogenase n=11 Tax=Eutheria... 402 e-110 UniRef50_Q5HNI1 D-3-phosphoglycerate dehydrogenase n=73 Tax=Stap... 402 e-110 UniRef50_B0TB58 Glyoxylate reductase n=7 Tax=cellular organisms ... 400 e-110 UniRef50_C0WBM0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acida... 399 e-110 UniRef50_Q3AQU0 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chlor... 399 e-109 UniRef50_D1U9G1 D-isomer specific 2-hydroxyacid dehydrogenase NA... 397 e-109 UniRef50_A6G5P3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Plesi... 396 e-109 UniRef50_D2C7W6 D-isomer specific 2-hydroxyacid dehydrogenase NA... 396 e-109 UniRef50_B3T9W6 Putative D-isomer specific 2-hydroxyacid dehydro... 396 e-109 UniRef50_C0GLG9 D-isomer specific 2-hydroxyacid dehydrogenase NA... 396 e-109 UniRef50_B9L1V2 Glyoxylate reductase n=2 Tax=Thermomicrobia (cla... 395 e-108 UniRef50_B8I0H1 D-3-phosphoglycerate dehydrogenase n=13 Tax=Clos... 394 e-108 UniRef50_UPI00016C495D phosphoglycerate dehydrogenase n=1 Tax=Ge... 394 e-108 UniRef50_A7SFV8 Predicted protein (Fragment) n=1 Tax=Nematostell... 393 e-108 UniRef50_A6CKS4 Putative uncharacterized protein n=2 Tax=Bacilla... 393 e-108 UniRef50_Q18DJ4 Phosphoglycerate dehydrogenase n=13 Tax=Halobact... 392 e-107 UniRef50_A5IK90 D-isomer specific 2-hydroxyacid dehydrogenase, N... 392 e-107 UniRef50_C4DLZ3 Lactate dehydrogenase-like oxidoreductase n=1 Ta... 392 e-107 UniRef50_A8A9G4 D-isomer specific 2-hydroxyacid dehydrogenase, N... 391 e-107 UniRef50_Q1K3M3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Desul... 391 e-107 UniRef50_A1HSQ7 D-isomer specific 2-hydroxyacid dehydrogenase, N... 388 e-106 UniRef50_B0KD78 D-isomer specific 2-hydroxyacid dehydrogenase, N... 387 e-106 UniRef50_D0MDQ9 D-isomer specific 2-hydroxyacid dehydrogenase NA... 387 e-106 UniRef50_Q4WHR3 D-3-phosphoglycerate dehydrogenase n=3 Tax=Eurot... 387 e-106 UniRef50_C2HP35 Glyoxylate reductase n=10 Tax=Lactobacillus RepI... 387 e-106 UniRef50_A7GQE1 D-isomer specific 2-hydroxyacid dehydrogenase NA... 387 e-106 UniRef50_C4XIX3 Putative D-isomer specific 2-hydroxyacid dehydro... 386 e-106 UniRef50_C2D1B3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Lacto... 386 e-106 UniRef50_A6C2G1 Phosphoglycerate dehydrogenase (SerA) n=1 Tax=Pl... 386 e-105 UniRef50_B7CA05 Putative uncharacterized protein n=1 Tax=Eubacte... 386 e-105 UniRef50_Q6A895 D-3-phosphoglycerate dehydrogenase n=4 Tax=Actin... 385 e-105 UniRef50_Q1J0H2 D-3-phosphoglycerate dehydrogenase n=8 Tax=Deino... 385 e-105 UniRef50_A9A5A9 Glyoxylate reductase n=2 Tax=Thaumarchaeota RepI... 385 e-105 UniRef50_B1KZ88 D-isomer specific 2-hydroxyacid dehydrogenase fa... 385 e-105 UniRef50_C9MSC4 Glycerate dehydrogenase n=3 Tax=Prevotella RepID... 384 e-105 UniRef50_D1YY17 Glycerate dehydrogenase n=1 Tax=Methanocella pal... 384 e-105 UniRef50_C0CRA6 Putative uncharacterized protein n=2 Tax=Clostri... 383 e-105 UniRef50_A7NS02 Glyoxylate reductase n=8 Tax=Bacteria RepID=A7NS... 382 e-104 UniRef50_O32264 Probable 2-ketogluconate reductase n=7 Tax=Bacil... 382 e-104 UniRef50_Q46AE6 Glycerate dehydrogenase n=2 Tax=Methanosarcina R... 382 e-104 UniRef50_A9KPU0 D-isomer specific 2-hydroxyacid dehydrogenase NA... 380 e-104 UniRef50_UPI0001BC4ADC hypothetical protein FulcA4_06865 n=1 Tax... 379 e-103 UniRef50_B0NG91 Putative uncharacterized protein n=1 Tax=Clostri... 375 e-102 UniRef50_D1C3Y3 D-isomer specific 2-hydroxyacid dehydrogenase NA... 375 e-102 UniRef50_A5W066 D-isomer specific 2-hydroxyacid dehydrogenase, N... 373 e-102 UniRef50_C2HJZ3 Possible glyoxylate reductase n=2 Tax=Finegoldia... 373 e-102 UniRef50_Q5WLJ2 D-3-phosphoglycerate dehydrogenase n=7 Tax=Bacte... 373 e-102 UniRef50_Q0W672 Glycerate dehydrogenase n=2 Tax=Archaea RepID=Q0... 372 e-101 UniRef50_A6Q7Q2 D-3-phosphoglycerate dehydrogenase n=49 Tax=Epsi... 372 e-101 UniRef50_C5EL38 D-3-phosphoglycerate dehydrogenase n=1 Tax=Clost... 372 e-101 UniRef50_B0P693 Putative uncharacterized protein n=2 Tax=Clostri... 372 e-101 UniRef50_A7VV70 Putative uncharacterized protein n=1 Tax=Clostri... 372 e-101 UniRef50_D1VVP3 Phosphoglycerate dehydrogenase n=1 Tax=Peptoniph... 371 e-101 UniRef50_Q7UQC8 Probable 2-hydroxyacid dehydrogenase n=3 Tax=Bac... 370 e-101 UniRef50_UPI000038E3F5 glyoxylate reductase n=1 Tax=Ferroplasma ... 369 e-100 UniRef50_B8FRA5 D-isomer specific 2-hydroxyacid dehydrogenase NA... 368 e-100 UniRef50_C4ZHF5 Phosphoglycerate dehydrogenase, putative n=3 Tax... 367 e-100 UniRef50_UPI0001972FE9 D-isomer specific 2-hydroxyacid dehydroge... 367 e-100 UniRef50_A0Y9Y1 Glyoxylate reductase n=3 Tax=unclassified Gammap... 367 e-100 UniRef50_A1HMI9 Phosphoglycerate dehydrogenase n=1 Tax=Thermosin... 366 e-100 UniRef50_A9BJ57 D-isomer specific 2-hydroxyacid dehydrogenase NA... 366 e-100 UniRef50_A5N5A9 SerA n=3 Tax=Clostridium RepID=A5N5A9_CLOK5 366 1e-99 UniRef50_B8FRV3 D-isomer specific 2-hydroxyacid dehydrogenase NA... 366 1e-99 UniRef50_B2I1D3 Phosphoglycerate dehydrogenase n=2 Tax=Acinetoba... 366 1e-99 UniRef50_Q71VT7 D-isomer specific 2-hydroxyacid dehydrogenase fa... 365 2e-99 UniRef50_A9A1H5 D-isomer specific 2-hydroxyacid dehydrogenase NA... 365 2e-99 UniRef50_C6PA05 D-isomer specific 2-hydroxyacid dehydrogenase NA... 365 2e-99 UniRef50_A0Q365 D-isomer specific 2-hydroxyacid dehydrogenases n... 364 3e-99 UniRef50_Q04AA8 Lactate dehydrogenase related enzyme n=3 Tax=Fir... 364 4e-99 UniRef50_P0A545 D-3-phosphoglycerate dehydrogenase n=57 Tax=Acti... 364 4e-99 UniRef50_A8MD25 D-isomer specific 2-hydroxyacid dehydrogenase NA... 363 5e-99 UniRef50_Q160B1 Glyoxylate reductase n=24 Tax=Bacteria RepID=Q16... 363 6e-99 UniRef50_B0PD17 Putative uncharacterized protein n=1 Tax=Anaerot... 363 6e-99 UniRef50_C5PUM3 Glyoxylate reductase n=2 Tax=Sphingobacterium sp... 363 7e-99 UniRef50_Q3SK87 D-isomer specific 2-hydroxyacid dehydrogenase n=... 363 7e-99 UniRef50_UPI000197AFFA hypothetical protein BACCOPRO_00987 n=1 T... 362 1e-98 UniRef50_B3SAF7 Putative uncharacterized protein n=1 Tax=Trichop... 362 1e-98 UniRef50_B1ZP48 D-isomer specific 2-hydroxyacid dehydrogenase NA... 362 2e-98 UniRef50_A0LN07 D-isomer specific 2-hydroxyacid dehydrogenase, N... 361 2e-98 UniRef50_Q3KHS7 2-ketogluconate reductase n=24 Tax=Proteobacteri... 361 2e-98 UniRef50_O33116 D-3-phosphoglycerate dehydrogenase n=22 Tax=Acti... 361 2e-98 UniRef50_A1RDF9 D-isomer specific 2-hydroxyacid dehydrogenase fa... 361 3e-98 UniRef50_C0BYY9 Putative uncharacterized protein n=1 Tax=Clostri... 361 4e-98 UniRef50_C3XIZ9 D-3-phosphoglycerate dehydrogenase n=4 Tax=Campy... 360 4e-98 UniRef50_D1CGN8 D-isomer specific 2-hydroxyacid dehydrogenase NA... 360 6e-98 UniRef50_B1R2D5 Glycerate dehydrogenase n=6 Tax=Clostridiales Re... 360 7e-98 UniRef50_A1R7L8 D-3-phosphoglycerate dehydrogenase n=35 Tax=Acti... 360 8e-98 UniRef50_C7H045 D-isomer specific 2-hydroxyacid dehydrogenase fa... 359 9e-98 UniRef50_D2RN56 D-isomer specific 2-hydroxyacid dehydrogenase NA... 359 9e-98 UniRef50_B0K1J9 D-isomer specific 2-hydroxyacid dehydrogenase, N... 359 9e-98 UniRef50_A3MTB6 D-isomer specific 2-hydroxyacid dehydrogenase, N... 359 1e-97 UniRef50_C1A4S7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Gemma... 359 1e-97 UniRef50_A3CQK1 Glyoxylate reductase, NADH-dependent, putative n... 358 1e-97 UniRef50_Q7WEA3 Phosphoglycerate dehydrogenase n=1 Tax=Bordetell... 358 2e-97 UniRef50_Q8ZXX8 D-3-phosphoglycerate dehydrogenase (SerA) n=1 Ta... 358 2e-97 UniRef50_Q0AFR7 D-3-phosphoglycerate dehydrogenase n=22 Tax=Bact... 358 2e-97 UniRef50_Q03YV3 Lactate dehydrogenase related enzyme n=2 Tax=Leu... 358 2e-97 UniRef50_D1W6S1 4-phosphoerythronate dehydrogenase n=4 Tax=Prevo... 358 2e-97 UniRef50_D2LZ49 D-isomer specific 2-hydroxyacid dehydrogenase NA... 358 3e-97 UniRef50_B9XQY4 D-isomer specific 2-hydroxyacid dehydrogenase NA... 358 3e-97 UniRef50_B0PHF7 Putative uncharacterized protein n=1 Tax=Anaerot... 357 4e-97 UniRef50_Q5WAF3 2-ketogluconate reductase n=2 Tax=Bacteria RepID... 357 4e-97 UniRef50_B6YUM0 D-isomer specific 2-hydroxyacid dehydrogenase n=... 357 5e-97 UniRef50_C0C1A5 Putative uncharacterized protein n=1 Tax=Clostri... 356 7e-97 UniRef50_C0QCQ5 GyaR n=2 Tax=Bacteria RepID=C0QCQ5_DESAH 356 8e-97 UniRef50_Q7D366 Putative phosphoglycerate dehydrogenase n=1 Tax=... 356 9e-97 UniRef50_C8QAG5 D-isomer specific 2-hydroxyacid dehydrogenase NA... 355 1e-96 UniRef50_Q04DF1 D-3-phosphoglycerate dehydrogenase n=1 Tax=Oenoc... 355 1e-96 UniRef50_C4V5E1 D-isomer specific 2-hydroxyacid dehydrogenase, N... 355 1e-96 UniRef50_Q6KZ29 Gluconate 2-dehydrogenase n=1 Tax=Picrophilus to... 355 2e-96 UniRef50_C7TNB9 D-isomer specific 2-hydroxyacid dehydrogenase, N... 355 2e-96 UniRef50_A8MCX1 D-isomer specific 2-hydroxyacid dehydrogenase NA... 355 2e-96 UniRef50_B2RGZ9 D-isomer specific 2-hydroxyacid dehydrogenase fa... 355 2e-96 UniRef50_Q8CPW2 Glycerate dehydrogenase n=6 Tax=Staphylococcus R... 355 2e-96 UniRef50_Q65WI5 SerA protein n=1 Tax=Mannheimia succiniciproduce... 354 3e-96 UniRef50_B2T8V2 D-isomer specific 2-hydroxyacid dehydrogenase NA... 354 3e-96 UniRef50_A4YUP8 Putative D-3-phosphoglycerate dehydrogenase (PGD... 354 3e-96 UniRef50_C1SG57 Lactate dehydrogenase-like oxidoreductase n=1 Ta... 354 4e-96 UniRef50_Q8EMM3 Dehydrogenase n=5 Tax=Bacteria RepID=Q8EMM3_OCEIH 354 4e-96 UniRef50_C0DAP4 Putative uncharacterized protein n=3 Tax=Clostri... 353 5e-96 UniRef50_Q031D4 D-3-phosphoglycerate dehydrogenase n=9 Tax=Strep... 353 6e-96 UniRef50_A5VTC2 D-isomer specific 2-hydroxyacid dehydrogenases f... 353 7e-96 UniRef50_A7VWU5 Putative uncharacterized protein n=1 Tax=Clostri... 353 7e-96 UniRef50_UPI0001973600 D-3-phosphoglycerate dehydrogenase n=1 Ta... 353 8e-96 UniRef50_B2KCL9 D-isomer specific 2-hydroxyacid dehydrogenase NA... 353 9e-96 UniRef50_UPI0001B4E409 glyoxylate reductase n=2 Tax=Streptomyces... 353 1e-95 UniRef50_A8R8D3 Putative uncharacterized protein n=2 Tax=unclass... 352 1e-95 UniRef50_UPI00016C0F1F D-isomer specific 2-hydroxyacid dehydroge... 351 2e-95 UniRef50_A6ULR7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 351 2e-95 UniRef50_Q6F7L0 Glycerate dehydrogenase n=3 Tax=Proteobacteria R... 351 2e-95 UniRef50_B2IKB7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 351 2e-95 UniRef50_A6TL35 D-isomer specific 2-hydroxyacid dehydrogenase, N... 351 3e-95 UniRef50_Q59516 Glycerate dehydrogenase n=35 Tax=Proteobacteria ... 351 3e-95 UniRef50_C6VZ76 D-isomer specific 2-hydroxyacid dehydrogenase NA... 351 3e-95 UniRef50_C0C032 Putative uncharacterized protein n=2 Tax=Firmicu... 351 3e-95 UniRef50_Q214B1 D-isomer specific 2-hydroxyacid dehydrogenase, N... 351 4e-95 UniRef50_A4YFM2 D-isomer specific 2-hydroxyacid dehydrogenase, N... 350 4e-95 UniRef50_A4FIF2 D-3-phosphoglycerate dehydrogenase n=1 Tax=Sacch... 350 4e-95 UniRef50_B6G9P0 Putative uncharacterized protein n=3 Tax=Bacteri... 350 4e-95 UniRef50_B8J355 D-isomer specific 2-hydroxyacid dehydrogenase NA... 350 4e-95 UniRef50_C0WBB3 D-isomer specific 2-hydroxyacid dehydrogenase n=... 350 4e-95 UniRef50_A8IH65 D-isomer specific 2-hydroxyacid dehydrogenase n=... 350 4e-95 UniRef50_C7H518 Glycerate dehydrogenase n=3 Tax=cellular organis... 350 4e-95 UniRef50_Q8EP33 Glycerate dehydrogenase n=2 Tax=Bacillaceae RepI... 350 5e-95 UniRef50_Q6MN05 Phosphoglycerate dehydrogenase n=1 Tax=Bdellovib... 350 5e-95 UniRef50_A1W9A3 D-isomer specific 2-hydroxyacid dehydrogenase, N... 350 6e-95 UniRef50_A7ZTA0 Glyoxylate/hydroxypyruvate reductase B n=224 Tax... 350 6e-95 UniRef50_C4TXE2 D-3-phosphoglycerate dehydrogenase n=3 Tax=Bacte... 350 6e-95 UniRef50_B2A705 D-isomer specific 2-hydroxyacid dehydrogenase NA... 350 7e-95 UniRef50_A1W7V5 D-isomer specific 2-hydroxyacid dehydrogenase, N... 350 7e-95 UniRef50_UPI0001C36DF4 D-isomer specific 2-hydroxyacid dehydroge... 349 1e-94 UniRef50_C0YQP9 Possible glyoxylate reductase n=1 Tax=Chryseobac... 349 1e-94 UniRef50_B7ALT2 Putative uncharacterized protein n=1 Tax=Bactero... 349 1e-94 UniRef50_UPI0001973D95 D-3-phosphoglycerate dehydrogenase n=1 Ta... 349 1e-94 UniRef50_B3T034 Putative D-isomer specific 2-hydroxyacid dehydro... 349 1e-94 UniRef50_D1CAH7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 348 2e-94 UniRef50_A1AQ02 D-isomer specific 2-hydroxyacid dehydrogenase, N... 348 2e-94 UniRef50_A8FRW0 D-isomer specific 2-hydroxyacid dehydrogenase, N... 348 2e-94 UniRef50_Q49ZM5 Putative 2-hydroxyacid dehydrogenase SSP0606 n=2... 348 3e-94 UniRef50_B0JPW3 McyI protein n=6 Tax=Cyanobacteria RepID=B0JPW3_... 348 3e-94 UniRef50_C3BRQ1 D-isomer specific 2-hydroxyacid dehydrogenase, N... 348 3e-94 UniRef50_Q1GAM7 D-isomer specific 2-hydroxyacid dehydrogenase n=... 347 4e-94 UniRef50_Q03WU1 Lactate dehydrogenase related dehydrogenase n=3 ... 347 5e-94 UniRef50_Q46NL3 D-isomer specific 2-hydroxyacid dehydrogenase, c... 347 5e-94 Sequences not found previously or not previously below threshold: >UniRef50_P43885 D-3-phosphoglycerate dehydrogenase n=399 Tax=Bacteria RepID=SERA_HAEIN Length = 410 Score = 485 bits (1249), Expect = e-135, Method: Composition-based stats. Identities = 290/410 (70%), Positives = 341/410 (83%), Gaps = 3/410 (0%) Query: 2 AKVSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRS 61 KVSL+K KIKF+L EGVHQ AL++L AAGYTNI+++K ALD ++LKE+I+D HFIGLRS Sbjct: 3 NKVSLDKSKIKFVLFEGVHQSALDTLHAAGYTNIDYYKKALDGDELKEAIKDVHFIGLRS 62 Query: 62 RTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELL 121 RTHLT ++I AA KL+A+GCFCIGTNQVDL+AA RGIPVFNAPFSNTRSVAELV+GE+L Sbjct: 63 RTHLTAEMIEAAPKLIAVGCFCIGTNQVDLNAAKARGIPVFNAPFSNTRSVAELVLGEIL 122 Query: 122 LLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD 181 LL+R VP+ANA+ HRGVWNK A GS E RGKKLGIIGYGHIG+QL I+AESLGM VYFYD Sbjct: 123 LLMRNVPQANAEVHRGVWNKSATGSHEVRGKKLGIIGYGHIGSQLSIIAESLGMDVYFYD 182 Query: 182 IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 IENKLPLGNA QV+ L +LL+ DVVSLHVPE PSTKN+M I+ +K G++LINA+RG Sbjct: 183 IENKLPLGNAKQVRSLEELLSSCDVVSLHVPELPSTKNLMNVARIAQLKQGAILINAARG 242 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 TVVDI AL AL L GAAIDVFP EPA+ ++ F SPL EFDNV+LTPHIGGST EAQ Sbjct: 243 TVVDIDALAQALKDGKLQGAAIDVFPVEPASINEEFISPLREFDNVILTPHIGGSTAEAQ 302 Query: 302 ENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGG-RRLMHIHENRPGVLTALNKIFAE 360 ENIG EVAGK +KYSDNGSTLS+VNFPEVSLP H G +RL+HIHENRPG+L LN+IF E Sbjct: 303 ENIGFEVAGKFVKYSDNGSTLSSVNFPEVSLPEHEGTKRLLHIHENRPGILNKLNQIFVE 362 Query: 361 QGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY 410 +NIAAQYLQT ++GYVV+D+E ++ A L +K I GTIRAR+LY Sbjct: 363 ANLNIAAQYLQTDPKIGYVVVDVETND--ASPLLTKLKEIDGTIRARVLY 410 >UniRef50_D2RHI0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RHI0_ARCPR Length = 525 Score = 479 bits (1233), Expect = e-133, Method: Composition-based stats. Identities = 120/395 (30%), Positives = 195/395 (49%), Gaps = 13/395 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ + + ++A++ ++ G K + E+L E I+D + +RSRT +T DVI Sbjct: 1 MKVLVADPIAEEAIDFMKKNGLEV--DVKTDISHEELLEVIQDYDALIVRSRTRVTRDVI 58 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 + A+KL IG +G + +D+D A ++GI V NAP N+ S AE IG +L + R +P+A Sbjct: 59 DRAKKLKIIGRAGVGVDNIDVDYATEKGIVVVNAPGGNSVSAAEHTIGLILSIARKIPQA 118 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + G W + E RGK LGI+G G IG ++ M + YD Sbjct: 119 DRSVKEGKWERKKFVGIELRGKTLGIVGLGRIGYEVAKRMRCFEMNILAYDPYVSEERAK 178 Query: 191 --ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 ++ L +LL SD++++HVP+ T+ M+ KE +MK G +INA+RG +VD A Sbjct: 179 SVGAKLVSLEELLRNSDIITIHVPKTKETEKMISYKEFEIMKDGVYIINAARGGIVDEKA 238 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L DAL S +AGAA+DV+ EP + PL + +NV+ TPHIG ST+EAQ +G+ V Sbjct: 239 LYDALVSGKVAGAALDVYEKEPPDKDN----PLLKLENVVTTPHIGASTREAQMMVGMTV 294 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 A ++ + +AVN P ++ + + G + A Sbjct: 295 AEDIVNFFKGLPVKNAVNLPSIAPEDYNFLMPFVELAEKIGKIA-----CARLNGVFNKV 349 Query: 369 YLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGT 403 + ++ +I + Q + + Sbjct: 350 KITFRGEIAKRNTEIVTRALLKGLLSQILSGVNIV 384 Score = 45.4 bits (107), Expect = 0.004, Method: Composition-based stats. Identities = 18/79 (22%), Positives = 38/79 (48%), Gaps = 2/79 (2%) Query: 334 LHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQM--GYVVIDIEADEDVAE 391 + G ++ +HE++PGV+ + + + +NIA + G ++ + D+ E Sbjct: 446 VPKGHYVISLHEDKPGVIGRVGTLMGKYNINIAGMIVGRYGDKPGGIQLMLLLLDDPPTE 505 Query: 392 KALQAMKAIPGTIRARLLY 410 + L+ M + G I A +Y Sbjct: 506 EILKKMVELEGIIDATYVY 524 >UniRef50_O27051 D-3-phosphoglycerate dehydrogenase n=16 Tax=Archaea RepID=SERA_METTH Length = 525 Score = 468 bits (1206), Expect = e-130, Method: Composition-based stats. Identities = 121/378 (32%), Positives = 187/378 (49%), Gaps = 15/378 (3%) Query: 8 KDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 ++K L+ + +++K + + E+L ++I+D I +RSRT +T Sbjct: 1 MSRMKVLIADSINEKGISE---LEEVAEVVVNTTITPEELLDAIKDFDAIVVRSRTKVTR 57 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 +VI AA +L I +G + VD+ AA RGI V NAP S + +VAE IG +L L R + Sbjct: 58 EVIEAAPRLKIIARAGVGVDNVDVKAATDRGIMVINAPESTSITVAEHSIGLMLALARKI 117 Query: 128 PEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP 187 A+ G W K E GK LGIIG G IG+Q+ + ++ GM + YD Sbjct: 118 AIADRSVKEGKWEKNRFMGIELNGKTLGIIGMGRIGSQVVVRTKAFGMDIMVYDPYISKE 177 Query: 188 LGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 V L LL SD+V++HVP P T++++ E LMK + ++N +RG ++D Sbjct: 178 AAEEMGVTVTDLETLLRESDIVTIHVPLTPETRHLISEDEFKLMKDTAFIVNCARGGIID 237 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL AL +AGAA+DVF EP P SPL E +NV+LTPHIG ST EAQ + Sbjct: 238 EDALYRALKDGEIAGAALDVFEEEP-----PEGSPLLELENVVLTPHIGASTSEAQRDAA 292 Query: 306 LEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNI 365 + VA ++ G+ + +N P + + + + G + + + NI Sbjct: 293 IIVANEIKTVFQGGAPRNVLNMPVMDSETYKSLKPYIELAEKMGAI--IAQALP---GNI 347 Query: 366 AAQYLQTSAQMGYVVIDI 383 + ++ + DI Sbjct: 348 EKLDVTYCGELAEMQFDI 365 Score = 48.8 bits (116), Expect = 3e-04, Method: Composition-based stats. Identities = 15/79 (18%), Positives = 35/79 (44%), Gaps = 1/79 (1%) Query: 325 VNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIE 384 +N V + G ++ + + PG + A+ + G+NIA + G V+ ++ Sbjct: 440 INGYRVDVKPEGTM-IIARYRDLPGTIGAIGTKLGQHGINIATMQVGRKEIGGEAVMVLK 498 Query: 385 ADEDVAEKALQAMKAIPGT 403 D+ V + ++ +K + Sbjct: 499 VDQSVPAEVIEEVKKLDNV 517 >UniRef50_C6W4R7 HAD-superfamily hydrolase, subfamily IB (PSPase-like) n=40 Tax=Bacteria RepID=C6W4R7_DYAFD Length = 635 Score = 466 bits (1200), Expect = e-130, Method: Composition-based stats. Identities = 223/407 (54%), Positives = 291/407 (71%), Gaps = 4/407 (0%) Query: 5 SLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTH 64 S K +IK LL+E VH A ++ G+ N+EF KGALD+++L E I+D IG+RS+T Sbjct: 232 SYPKSRIKVLLLENVHPVARKAFEDEGF-NVEFVKGALDEDELCERIKDVSIIGIRSKTT 290 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 +T+ V+ A +L+AIG FCIGTNQ+DLD AAK+GI VFNAP+SNTRSV EL +GE++LL+ Sbjct: 291 ITKRVLEHANRLMAIGAFCIGTNQIDLDEAAKKGIAVFNAPYSNTRSVVELAVGEMILLI 350 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 R + + H+G+W+K A GSFE RGKKLG++GYG IGTQL ++AE+LGM VYFYD Sbjct: 351 RNIVGKSNSMHKGIWDKSANGSFEIRGKKLGMVGYGSIGTQLSVVAEALGMDVYFYDAVE 410 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 KL +GNA +V L +LL MSDV+SLHV NM+G +E LMK G + +N SRG VV Sbjct: 411 KLSIGNAKKVNTLEELLAMSDVLSLHVDGRKENTNMIGKREFDLMKDGVIFLNLSRGHVV 470 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 DI AL DA+ S +AGA +DVFP EP TN + F S L NV+LTPHIGGST+EAQENI Sbjct: 471 DIKALADAVKSGKVAGAGVDVFPKEPKTNDEMFESELLGLPNVILTPHIGGSTEEAQENI 530 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEVSLP-LHGGRRLMHIHENRPGVLTALNKIFAEQGV 363 G V KL+++ +NGS+ +VNFPEV LP L RL+HIH N PGVL LN+IFA+ + Sbjct: 531 GHFVPSKLLEFMNNGSSYGSVNFPEVQLPKLKDSHRLLHIHANVPGVLAKLNQIFAKNNI 590 Query: 364 NIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY 410 NI QYL+T+ +GYV++DI D E+ +Q +K + GTIR R+LY Sbjct: 591 NITGQYLKTNEHIGYVIVDIAKDYT--EEFIQEVKEVEGTIRFRMLY 635 >UniRef50_A1W4D0 D-3-phosphoglycerate dehydrogenase n=26 Tax=cellular organisms RepID=A1W4D0_ACISJ Length = 434 Score = 465 bits (1197), Expect = e-129, Method: Composition-based stats. Identities = 260/411 (63%), Positives = 321/411 (78%), Gaps = 3/411 (0%) Query: 1 MAKVSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLR 60 MAK SL+K KIKFLL+EG+H A+E LR+AGYT +E GAL+ E+L+ I D HFIG+R Sbjct: 26 MAKTSLDKSKIKFLLLEGIHPSAVEVLRSAGYTQVEVLAGALEGEELRRKIADVHFIGIR 85 Query: 61 SRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGEL 120 SRT LT DV A KLVA+GCFCIGTNQVDL+AA +RGI VFNAP+SNTRSVAELV+ E Sbjct: 86 SRTQLTADVFAHAHKLVAVGCFCIGTNQVDLNAARERGIAVFNAPYSNTRSVAELVLAEA 145 Query: 121 LLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 +LLLRGVPE NA AHRG W K A ++E RGK LGI+GYG IGTQL +LAE+LGM+V F+ Sbjct: 146 ILLLRGVPEKNAAAHRGGWLKSATNAYEIRGKTLGIVGYGSIGTQLSVLAEALGMHVIFH 205 Query: 181 DIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 D+ +KLPLGNA QV L +LL +D+V+LHVPE PST+ M+GA EI+ MKPG +LINASR Sbjct: 206 DVVHKLPLGNARQVGSLHELLGQADIVTLHVPELPSTQWMIGAAEIAAMKPGGILINASR 265 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 GTVV+I L AL +L GAA+DVFP EP +N D F SPL DN LLTPHIGGST EA Sbjct: 266 GTVVEIDPLAQALKGGNLLGAAVDVFPVEPKSNKDEFVSPLRGLDNALLTPHIGGSTMEA 325 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLH-GGRRLMHIHENRPGVLTALNKIFA 359 Q NIGLEVA KL++YSDNG++ S+VNFPEV+LP H G RL+H+H N PGVL+ +N I + Sbjct: 326 QANIGLEVAEKLVRYSDNGTSTSSVNFPEVALPEHAGKHRLLHVHHNVPGVLSQINSILS 385 Query: 360 EQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY 410 + +NIAAQYLQT+ ++GYVVID+ D ++ AL+ + +PGTIR+R+LY Sbjct: 386 DNHINIAAQYLQTNEKIGYVVIDL--DARSSDLALEKLAQVPGTIRSRVLY 434 >UniRef50_O29445 D-3-phosphoglycerate dehydrogenase n=8 Tax=cellular organisms RepID=SERA_ARCFU Length = 527 Score = 462 bits (1191), Expect = e-129, Method: Composition-based stats. Identities = 111/377 (29%), Positives = 184/377 (48%), Gaps = 13/377 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ E + ++A++ +R G K + E+L + I +RS+T + +VI Sbjct: 1 MKVLVAEPISEEAIDYMRKNGLEV--EVKTGMSREELIREVPKYEAIVVRSQTKVDAEVI 58 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA+ L IG +G + +D++AA +RGI V NAP NT S AE I +L R +P+A Sbjct: 59 QAAKNLKIIGRAGVGVDNIDINAATQRGIVVVNAPGGNTISTAEHAIALMLAAARKIPQA 118 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + G W + E RGK G+IG G +G ++ ++L M V YD Sbjct: 119 DRSVKEGKWERKKFMGIELRGKTAGVIGLGRVGFEVAKRCKALEMNVLAYDPFVSKERAE 178 Query: 191 --ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 ++ LL SDV+++HVP T ++G + MK G +++NA+RG +VD A Sbjct: 179 QIGVKLVDFDTLLASSDVITVHVPRTKETIGLIGKGQFEKMKDGVIVVNAARGGIVDEAA 238 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +A+ + +A AA+DV+ EP + + PL + DNV+ TPHI ST+EAQ N+G+ + Sbjct: 239 LYEAIKAGKVAAAALDVYEKEPPSPDN----PLLKLDNVVTTPHIAASTREAQLNVGMII 294 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 A ++ + +AVN P + + G + ++ G I Sbjct: 295 AEDIVNMAKGLPVRNAVNLPSIEPSDFEFMMPFLTLAEKMGKIASV-----RLGGAIRKV 349 Query: 369 YLQTSAQMGYVVIDIEA 385 + S ++ + Sbjct: 350 KVTCSGKLATKNTEFVT 366 Score = 49.6 bits (118), Expect = 2e-04, Method: Composition-based stats. Identities = 20/82 (24%), Positives = 38/82 (46%), Gaps = 8/82 (9%) Query: 325 VNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQM--GYVVID 382 VNF + G ++ +HE++PGV+ + +F +NIA + S G ++ Sbjct: 445 VNF------VPKGHYIISLHEDKPGVIGRVGTLFGRNNINIAGMIVGRSGDKPGGIQLML 498 Query: 383 IEADEDVAEKALQAMKAIPGTI 404 + D+ + L+ M + G I Sbjct: 499 LLVDDPPTPEVLEEMTKLDGII 520 >UniRef50_Q1AXS3 D-3-phosphoglycerate dehydrogenase n=2 Tax=Actinobacteria (class) RepID=Q1AXS3_RUBXD Length = 527 Score = 462 bits (1190), Expect = e-128, Method: Composition-based stats. Identities = 128/390 (32%), Positives = 196/390 (50%), Gaps = 15/390 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 ++ L+ E + ++ +E LR ++ L +L E I + + +RS T +T +VI Sbjct: 1 MRVLVTEKLAERGVELLRREFEVDVLL---GLSPGELLERIGEYDGLIVRSATKVTAEVI 57 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA +L AIG IG + +D++AA KRGI V NAP SNT + AE +G +L + R +P A Sbjct: 58 EAAGRLKAIGRAGIGVDNIDIEAATKRGILVANAPESNTVAAAEHTLGLMLAVARRIPAA 117 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL-- 188 +A RG WN+ A E K LG++G GH+G+ + A +GM V YD Sbjct: 118 DASLRRGEWNRAAFKGVEVAEKTLGLVGLGHVGSIVARGALGMGMRVLAYDPYVSEERMR 177 Query: 189 -GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 N + L ++ +D VSLHVP P T M+G +E++ MKP + LIN +RG +VD Sbjct: 178 SMNVERAGSLEEIFEEADFVSLHVPRTPQTTGMVGEEELARMKPTAYLINVARGGIVDET 237 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL +AL +AGAA+DVF EP T SPL NV++TPH+G ST EAQ+ G+ Sbjct: 238 ALYNALKQGEIAGAALDVFAEEPTT-----DSPLFALPNVVVTPHLGASTAEAQDRAGVT 292 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAE-QGVNIA 366 A ++ + A+N P +P G + L L + G + Sbjct: 293 AAEQVAAALRGEVPIHAINAP---VPAGEGAEFVSQFAGLCETLGRLLYQLTDRPGSRLK 349 Query: 367 AQYLQTSAQMGYVVIDIEADEDVAEKALQA 396 +Y ++D+ + + + + Sbjct: 350 IEYRGEIGAYDTRLLDVSVQKGLLSRMVHE 379 Score = 50.7 bits (121), Expect = 9e-05, Method: Composition-based stats. Identities = 17/76 (22%), Positives = 33/76 (43%) Query: 334 LHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKA 393 + L +E+ PG++ + I E G+NI + + + DE V + Sbjct: 449 VPERHMLFIRNEDVPGMIGKVGTILGEHGINIGNMAVGRGEPGSRAAMAVTVDEPVPPEV 508 Query: 394 LQAMKAIPGTIRARLL 409 ++++ IPG AR + Sbjct: 509 VESLLNIPGFNDARAV 524 >UniRef50_A5D6D4 Phosphoglycerate dehydrogenase and related dehydrogenases n=3 Tax=Firmicutes RepID=A5D6D4_PELTS Length = 526 Score = 462 bits (1189), Expect = e-128, Method: Composition-based stats. Identities = 130/368 (35%), Positives = 197/368 (53%), Gaps = 14/368 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+++GV ++ L++LR ++ K + +++L +I D I +RS T +T +I Sbjct: 1 MKVLVLDGVEEEGLKALRQEPGIQVDV-KDKMSEDELVAAIGDYDGIIVRSATKVTARII 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A +L +G +G + +D+ AA RGI V NAP NT +VAE I +L L R +P+A Sbjct: 60 EKAARLKVVGRAGVGVDNIDVPAATARGILVVNAPEGNTLAVAEHTIAMMLSLARNIPQA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 NA G W+K + E RGK LG+IG G IG+ + A+ + M V YD Sbjct: 120 NASLRAGKWDKKSFMGVELRGKVLGVIGLGRIGSAVAKRAQGMEMKVVAYDPYINEEKAG 179 Query: 191 --ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + L +LL +D +++H+P +K M+G K SLMK G +IN +RG VVD A Sbjct: 180 LLGVTLLSLEELLKQADFITVHLPLTRESKYMLGEKAFSLMKDGVRIINCARGGVVDEQA 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +A+ S +AGAA+DVF EP T SPL EF N + TPH+G STQEAQ ++ +V Sbjct: 240 LYNAMKSGKVAGAALDVFEKEPNT-----DSPLFEFKNFIATPHLGASTQEAQLSVATDV 294 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPG------VLTALNKIFAEQG 362 A +++ +AVN P VS + + + G + +NKI A Sbjct: 295 AREVVAALKGELVKNAVNIPSVSPKVLAVIKPYLSLAEKMGKFAAQVICGRVNKIEATYS 354 Query: 363 VNIAAQYL 370 ++A Q + Sbjct: 355 GDLAGQEV 362 Score = 51.1 bits (122), Expect = 6e-05, Method: Composition-based stats. Identities = 13/75 (17%), Positives = 30/75 (40%) Query: 333 PLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEK 392 + G L H ++P ++ + + +NI+ + G V+ + D V E+ Sbjct: 448 AVPEGHMLYIPHIDKPRIIGPVGNLIGTHNINISGMQVGRKVIGGKAVMLLNIDSPVPEE 507 Query: 393 ALQAMKAIPGTIRAR 407 + + I G + + Sbjct: 508 TMAEIAKIDGVLGVK 522 >UniRef50_B8HPZ0 D-3-phosphoglycerate dehydrogenase n=26 Tax=cellular organisms RepID=B8HPZ0_CYAP4 Length = 652 Score = 458 bits (1179), Expect = e-127, Method: Composition-based stats. Identities = 114/390 (29%), Positives = 190/390 (48%), Gaps = 29/390 (7%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K L+ + + Q ++ L ++ L E+L + I D + +RS T +T+ VI Sbjct: 128 PKVLVSDPIDQVGIDLLAQVAQVDVRTD---LSPEELIQIIPDYDALMIRSGTKVTQAVI 184 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA +L IG +G + VD+ AA ++GI V N+P NT + AE + +L L R +P A Sbjct: 185 EAANQLKIIGRAGVGVDNVDVPAATRKGIVVVNSPEGNTIAAAEHTLAMMLSLSRHIPAA 244 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + G W++ + E K LG+IG G IG+ + +A ++GM + YD Sbjct: 245 SQSVKSGKWDRKSFTGVEVYKKTLGVIGLGKIGSHVATVARAMGMNLLAYDPYLSNERAE 304 Query: 191 --ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 ++ +L L +D ++LH+P+ P T++++ A+ ++ MKP + +IN +RG ++D A Sbjct: 305 QIGCRLVNLDLLFAEADYITLHLPKTPETQHLIKAETLARMKPTARIINCARGGIIDEAA 364 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDN-VLLTPHIGGSTQEAQENIGLE 307 L +AL +AGAA+DVF EP SPL V+LTPH+G ST+EAQ N+ ++ Sbjct: 365 LVEALKEGKIAGAALDVFENEPLGE-----SPLLSLGKEVVLTPHLGASTEEAQTNVAID 419 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAA 367 VA ++ SAVN P + + + AE N+ Sbjct: 420 VAEQIRDLFLGKPVRSAVNIPGLRPDVLEKLKPYL--------------QLAETLGNLVG 465 Query: 368 QYLQTSAQMGYVVIDIEADEDVAEKALQAM 397 Q + +D+ ++A Q + Sbjct: 466 QLAGGRIEA----LDVRLQGELASNDSQPI 491 Score = 48.4 bits (115), Expect = 5e-04, Method: Composition-based stats. Identities = 16/81 (19%), Positives = 32/81 (39%), Gaps = 6/81 (7%) Query: 324 AVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDI 383 +N P L+ +H + PG++ + + VNIA+ + G V+ + Sbjct: 571 PINVP------PTRHMLLTLHRDMPGIIGKIGSLLGSFNVNIASMQVGRKMVRGNAVMVL 624 Query: 384 EADEDVAEKALQAMKAIPGTI 404 D+ + E L + + G Sbjct: 625 SLDDPLPEGLLTEITKVSGIR 645 >UniRef50_C8WVY8 D-3-phosphoglycerate dehydrogenase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WVY8_ALIAD Length = 529 Score = 458 bits (1179), Expect = e-127, Method: Composition-based stats. Identities = 122/371 (32%), Positives = 189/371 (50%), Gaps = 9/371 (2%) Query: 12 KFLLVEGVHQKALESLRA-AGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K L+ + + Q ++ L G + + L ++LKE+I DA + +RS+T +T DVI Sbjct: 4 KILVTDDISQAGIDILSGLQGAEVV--VRTNLAPDELKEAIADADALVVRSQTRVTRDVI 61 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +A+KL IG +G + +DL+AA +RGI V NAP NT + AE ++ L R +P A Sbjct: 62 ESAKKLKVIGRAGVGVDNIDLEAATRRGILVINAPDGNTIAAAEHTFAMMISLARHIPAA 121 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + +G WN+ E RGK L ++G G IGT++ A++ GM V YD Sbjct: 122 HRDLLQGNWNRKKWIGVELRGKTLAVLGMGRIGTEVAKRAKAFGMTVLGYDPFLTEERAQ 181 Query: 191 --ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + L + +D +++H P T +M+ A I+ MK G +IN +RG ++D A Sbjct: 182 SLGVKRCDLDTAIREADFITVHTPLTKETHHMIDAGRIAQMKEGVRIINCARGGIIDEVA 241 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +AL + +AGAAIDVF EP P PL NV+LTPH+G ST EAQEN+ ++V Sbjct: 242 LAEALEAGRVAGAAIDVFEQEPL----PMDHPLRRCPNVVLTPHLGASTVEAQENVAIQV 297 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 A ++++ + + AVN P +S + G+ A A + + Sbjct: 298 AEEIVQVLRDDTFEHAVNLPSLSQRQKERLAPYLALAEQLGLFAAQLAQGAPSSMTVRYA 357 Query: 369 YLQTSAQMGYV 379 GY+ Sbjct: 358 GDAADPDGGYL 368 Score = 62.3 bits (151), Expect = 3e-08, Method: Composition-based stats. Identities = 15/70 (21%), Positives = 32/70 (45%) Query: 340 LMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKA 399 + HE+RPG++ + + ++ +NIA + G V+ + D+ V + + + Sbjct: 458 IYTRHEDRPGMIGRIGTLLGDRDINIAGMQVGRRETGGEAVMLLSVDKRVPQDVIDEIAK 517 Query: 400 IPGTIRARLL 409 PG R + Sbjct: 518 HPGIRLVRAI 527 >UniRef50_C6HZG9 D-3-phosphoglycerate dehydrogenase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HZG9_9BACT Length = 537 Score = 457 bits (1176), Expect = e-127, Method: Composition-based stats. Identities = 119/408 (29%), Positives = 191/408 (46%), Gaps = 20/408 (4%) Query: 9 DKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 KIK L+ + + ++ + + AG+ K L ++LK + + +RS T +T Sbjct: 5 HKIKILVSDPISEEGINIFKNAGFEVT--VKAKLSPDELKAELAHYDGLVIRSGTKVTAH 62 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 V+ A +L IG G + VDL AA RGI V N P NT + AE + ++ + R +P Sbjct: 63 VLEGATRLKVIGRAGAGLDNVDLPAATNRGIVVMNTPGGNTITTAEHTVSMMMSMARRIP 122 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL 188 +ANA G W K E K LGI+G G IG+ + +A+ L M V YD Sbjct: 123 QANASNRSGKWEKSKFMGIELAHKTLGILGMGKIGSHVAHVAQGLLMNVIAYDPFLTAES 182 Query: 189 G--NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + +L +D++++H P P T N++ + I+ MK G ++N +RG +V+ Sbjct: 183 AARQGVTPVTVEELFAKADIITVHTPLTPETTNLISSASIAKMKKGVYIVNCARGGIVNE 242 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 L AL S H+AGAA DVF EP + + PL + DN + TPHIG +T+EAQEN+ L Sbjct: 243 ADLAKALESGHVAGAAFDVFAEEPPSPDN----PLLKLDNFISTPHIGAATKEAQENVAL 298 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPG---------VLTALNKI 357 VA +++ Y G A N P V G + ++ Sbjct: 299 AVADQMVDYLAKGIIRYAANLPSVPPEDAARVTPYQQLAEVMGGILSQIATEAFSKISVE 358 Query: 358 FAEQGVNIAAQYLQTSAQMGYV--VIDIEADEDVAEKALQAMKAIPGT 403 F+ + + Q + +A G + ++D+ + +V L + + Sbjct: 359 FSGEAATLPTQIITIAALKGVLAPMLDVRVN-EVNAPLLAKERGLEVV 405 Score = 47.3 bits (112), Expect = 0.001, Method: Composition-based stats. Identities = 16/76 (21%), Positives = 31/76 (40%) Query: 334 LHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKA 393 + L ++++PGV+ + + G+NI+ G V I D + Sbjct: 455 VPDPIMLYLTNQDQPGVVGLVGSLLGSHGINISRMQFGRDFPGGKAVSMIGVDSEPPAAV 514 Query: 394 LQAMKAIPGTIRARLL 409 L+ ++ P I +LL Sbjct: 515 LEEIRKNPKIIALKLL 530 >UniRef50_P40054 D-3-phosphoglycerate dehydrogenase 1 n=76 Tax=cellular organisms RepID=SERA_YEAST Length = 469 Score = 455 bits (1173), Expect = e-126, Method: Composition-based stats. Identities = 199/414 (48%), Positives = 276/414 (66%), Gaps = 17/414 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K LL+E V+Q A+ GY +EF+K +L +E+L E I+D H IG+RS+T LT +V+ Sbjct: 59 MKILLLENVNQTAITIFEEQGYQ-VEFYKSSLPEEELIEKIKDVHAIGIRSKTRLTSNVL 117 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A+ LV IGCFCIGTNQVDLD A RGI VFN+PFSN+RSVAELVI E++ L R + + Sbjct: 118 QHAKNLVCIGCFCIGTNQVDLDYATSRGIAVFNSPFSNSRSVAELVIAEIISLARQLGDR 177 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + + H G WNK+AA +E RGK LGIIGYGHIG+QL +LAE++G++V +YDI + LG Sbjct: 178 SIELHTGTWNKVAARCWEVRGKTLGIIGYGHIGSQLSVLAEAMGLHVLYYDIVTIMALGT 237 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 A QV L +LLN SD V+LHVP P T+ M+ A + + MK G+ +INASRGTVVDIP+L Sbjct: 238 ARQVSTLDELLNKSDFVTLHVPATPETEKMLSAPQFAAMKDGAYVINASRGTVVDIPSLI 297 Query: 251 DALASKHLAGAAIDVFPTEPATNS--------DPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 A+ + +AGAA+DV+P EPA N + +TS L N++LTPHIGGST+EAQ Sbjct: 298 QAVKANKIAGAALDVYPHEPAKNGEGSFNDELNSWTSELVSLPNIILTPHIGGSTEEAQS 357 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVNFPEVSL-----PLHGGRRLMHIHENRPGVLTALNKI 357 +IG+EVA L KY + G+++ +VNFPEV+L R+++IH+N PGVL +N I Sbjct: 358 SIGIEVATALSKYINEGNSVGSVNFPEVALKSLSYDQENTVRVLYIHQNVPGVLKTVNDI 417 Query: 358 FAEQGVNIAAQYLQTSAQMGYVVIDI-EADEDVAEKALQAMKAIPGTIRARLLY 410 + NI Q+ ++ ++ Y++ DI D+ + + + I RLLY Sbjct: 418 LSNH--NIEKQFSDSNGEIAYLMADISSVDQSDIKDIYEQLNQTSAKISIRLLY 469 >UniRef50_A9EWF7 Phosphoglycerate dehydrogenase n=17 Tax=cellular organisms RepID=A9EWF7_SORC5 Length = 419 Score = 454 bits (1169), Expect = e-126, Method: Composition-based stats. Identities = 202/405 (49%), Positives = 282/405 (69%), Gaps = 4/405 (0%) Query: 7 EKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLT 66 K+ +K LL+E +HQ A E R+ + IE A+ +++L ++ +G+RS+TH+T Sbjct: 18 AKEPVKVLLLENIHQSAHELFRSRSFE-IETRSSAMKEDELIAALAGVDMLGIRSKTHVT 76 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 V+ A+KL++IGCFCIGTNQVDLDAA +RG+PVFNAPFSNTRSVAE++I E ++L R Sbjct: 77 ARVLEKADKLLSIGCFCIGTNQVDLDAANRRGVPVFNAPFSNTRSVAEMIIAESIMLARQ 136 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL 186 + + + + H G W K++ +E RGK +G+IGYGHIG QLG+LAE++GM V +YDI KL Sbjct: 137 LGDRSREVHAGTWKKVSKACYEIRGKTIGLIGYGHIGQQLGVLAEAMGMRVVYYDIAQKL 196 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 P+GN + L LL SD VSLHVP P T NM+GA E++ M+ G+ L+NASRG+VV I Sbjct: 197 PMGNNRALPTLEALLAESDFVSLHVPATPETHNMIGAAELAHMRKGAYLLNASRGSVVVI 256 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 PAL +AL S HLAGAAIDV+P EP +NSD F + L + NV+LTPHIGGST+EAQE IG Sbjct: 257 PALAEALKSGHLAGAAIDVYPEEPESNSDGFLTELQKLPNVILTPHIGGSTEEAQEAIGR 316 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEVSLPL-HGGRRLMHIHENRPGVLTALNKIFAEQGVNI 365 EV+ L + G+T AVNFP V LP R++++H N PGVL +N+I ++ NI Sbjct: 317 EVSRALTQLVTTGATTGAVNFPNVELPPLKATHRILNVHRNVPGVLRDVNRIVSDVNANI 376 Query: 366 AAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY 410 +Q L T A +GY+++D+ +DV+ + + + A+ +IR R+LY Sbjct: 377 DSQVLSTDANIGYLIMDLS--QDVSAEVSRRIGALETSIRTRVLY 419 >UniRef50_C5DTI9 ZYRO0C08932p n=1 Tax=Zygosaccharomyces rouxii RepID=C5DTI9_ZYGRO Length = 469 Score = 454 bits (1168), Expect = e-126, Method: Composition-based stats. Identities = 195/414 (47%), Positives = 266/414 (64%), Gaps = 17/414 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K LL+E V+ A+ GY +EFHK +L +E+L E I+D H IG+RS+T LT +V+ Sbjct: 59 MKILLLENVNATAVSIFEDQGYQ-VEFHKSSLPEEELIEKIKDVHAIGIRSKTKLTANVL 117 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A+ LV+IGCFCIGTNQVDL A GI VFN+PFSN+RSVAEL+IGE++ L R + + Sbjct: 118 KHAKNLVSIGCFCIGTNQVDLKYATHAGIAVFNSPFSNSRSVAELIIGEIISLARQLGDR 177 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + + H G WNK++ +E RGK LGIIGYGHIG+QL +LAE++GM+V +YD + LG Sbjct: 178 SIELHTGAWNKVSNRCWEVRGKTLGIIGYGHIGSQLSVLAEAMGMHVLYYDTVTIMALGT 237 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 A QV L +LLN SD ++ HVP P TKNM+ A + + MK G+ ++NASRGTVVDIPAL Sbjct: 238 ARQVPTLDELLNNSDFITCHVPATPETKNMLSAPQFAAMKEGAYVLNASRGTVVDIPALI 297 Query: 251 DALASKHLAGAAIDVFPTEPATNS--------DPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 A +AGAA+DV+P+EP N +P+ S L N++LTPHIGGST+EAQ Sbjct: 298 QAFKVGKIAGAALDVYPSEPGKNGAGAFSDDLNPWASELISLPNIILTPHIGGSTEEAQS 357 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVNFPEVSL-----PLHGGRRLMHIHENRPGVLTALNKI 357 IG+EVA L KY + G+++ +VNFPEVSL R+++IH N PGVL +N I Sbjct: 358 AIGVEVAASLTKYINEGTSVGSVNFPEVSLRSLDYDQENTVRVLYIHHNVPGVLKTVNNI 417 Query: 358 FAEQGVNIAAQYLQTSAQMGYVVIDIE-ADEDVAEKALQAMKAIPGTIRARLLY 410 + NI Q+ + + Y++ DI D+ + + I RLLY Sbjct: 418 LSNH--NIEKQFSDSKGDIAYLMADISNVDQSDIKNVYDELNQTDAKISIRLLY 469 >UniRef50_Q11WE3 Phosphoserine phosphatase and phosphoglycerate dehydrogenase (D-3-phosphoglycerate dehydrogenase) fusion n=85 Tax=Bacteria RepID=Q11WE3_CYTH3 Length = 633 Score = 451 bits (1161), Expect = e-125, Method: Composition-based stats. Identities = 205/408 (50%), Positives = 276/408 (67%), Gaps = 4/408 (0%) Query: 4 VSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRT 63 +S K++IK LL+E +H A + GY +E AL++++L E I+D IG+RS+T Sbjct: 229 ISYPKNRIKVLLLENIHTDAFKLFSEEGY-TVEVIASALEEDELIEKIKDVSIIGIRSKT 287 Query: 64 HLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLL 123 +T V+ A KL+AIG FCIGTNQ+DL AA +G+ VFNAPFSNTRSV EL IGE+++L Sbjct: 288 TITAKVLEHAPKLIAIGAFCIGTNQIDLKAAQMKGVAVFNAPFSNTRSVVELAIGEIIML 347 Query: 124 LRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE 183 R E + + H G W+K A SFE RGKKLG++GYG+IG+QL ++AESLGM VY+YDI Sbjct: 348 YRRTLEKSMQMHAGKWDKSAKNSFEIRGKKLGLVGYGNIGSQLSVIAESLGMVVYYYDIV 407 Query: 184 NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 +L LGNA + L +LLN DVVSLHV S K M GAKE + M+ GS+ +N +RG V Sbjct: 408 ERLSLGNAKKCSSLKELLNTVDVVSLHVDGRASNKGMFGAKEFNEMRQGSIFLNLARGPV 467 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 D+ AL + L S + GA +DV+ EP N + F + + NV+LTPHIGGST+EAQ N Sbjct: 468 TDLKALSENLKSGKILGAGLDVYEYEPKNNDEEFINDVRGLPNVILTPHIGGSTEEAQSN 527 Query: 304 IGLEVAGKLIKYSDNGSTLSAVNFPEVSLPL-HGGRRLMHIHENRPGVLTALNKIFAEQG 362 IG V ++ Y +NG+TL +VNFP + LP G R MH+HEN+PG+L +N +FA+ Sbjct: 528 IGNFVPNRITDYINNGTTLHSVNFPNIQLPELQEGHRFMHLHENQPGILAKINNLFAKHN 587 Query: 363 VNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY 410 +NI AQYL+T+ Q+GYV+ DI D ++ L +K IPGTIR R LY Sbjct: 588 INILAQYLKTNEQVGYVITDIAKIYD--KEVLDELKEIPGTIRFRTLY 633 >UniRef50_D2VJX3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VJX3_NAEGR Length = 405 Score = 449 bits (1155), Expect = e-124, Method: Composition-based stats. Identities = 199/409 (48%), Positives = 280/409 (68%), Gaps = 7/409 (1%) Query: 4 VSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRT 63 S K IK LL+E + Q A++ + G+ +E +L +E+L I D H +G+RS+T Sbjct: 2 TSYPKHLIKVLLLENISQTAVDLFKKEGFQ-VESVSKSLSEEELTVKIEDVHLVGIRSKT 60 Query: 64 HLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLL 123 LTE V++ A+KL A+GC+CIGT+QVDL+ K+GIPVFN+P++NTRSVAEL + E+++L Sbjct: 61 KLTEKVLSNAKKLKAVGCYCIGTDQVDLECCEKKGIPVFNSPYANTRSVAELAMSEIVML 120 Query: 124 LRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE 183 R V E H+G W K+A +E RGK LGI+GYGH+G+QLG+LAE GM V +YDIE Sbjct: 121 SRKVSEHVKSLHQGHWYKIAKDCYEIRGKILGIVGYGHVGSQLGLLAEGFGMSVIYYDIE 180 Query: 184 NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 +KLPLGNA V + +L+ + VSLHVP+ T N++G +I+ M+ GS L+N SRG+V Sbjct: 181 HKLPLGNAKPVDSMEQVLSTAHFVSLHVPKTEQTNNLIGEAQIAQMQKGSYLLNLSRGSV 240 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATN-SDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 VD+ AL AL S HL G A+DVFPTEP + + F+SPL N +LTPHIGGST EAQ+ Sbjct: 241 VDVNALASALKSGHLHGCAVDVFPTEPEKDGDNVFSSPLQNCPNTILTPHIGGSTIEAQD 300 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVNFPEVSL-PLHGGRRLMHIHENRPGVLTALNKIFAEQ 361 IG EVA KLI Y + G TL +VNFP+++ G RL+HIH NR GVL ++N + + Sbjct: 301 AIGKEVAQKLISYMNEGITLGSVNFPQINPVHYAGCHRLLHIHVNRHGVLKSINALLQDY 360 Query: 362 GVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY 410 N+ +Q L T+ +GY+VI++ D+ VAE+ + +K + TI+AR+L+ Sbjct: 361 --NVVSQLLGTTKHIGYMVIEL--DKSVAEEVFKQIKELESTIKARVLF 405 >UniRef50_B4D991 D-3-phosphoglycerate dehydrogenase n=3 Tax=Verrucomicrobia RepID=B4D991_9BACT Length = 530 Score = 448 bits (1153), Expect = e-124, Method: Composition-based stats. Identities = 119/361 (32%), Positives = 180/361 (49%), Gaps = 8/361 (2%) Query: 8 KDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 K K L+ + + QK ++ L G ++ K L ++L I + + + +RS T Sbjct: 1 MSKPKVLVADPIAQKGIDELANGGSLDVTV-KIGLKPDELLAIIGEFNALVVRSETKANA 59 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 VI AA L IG +G + VD+DAA KRGI V N P NT S AE ++ R + Sbjct: 60 KVIEAATNLKVIGRAGVGVDNVDVDAATKRGIIVMNTPGGNTISTAEHAFSLMVSTARNI 119 Query: 128 PEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP 187 P+A+A G W++ E K L I+G G IGT++ A + GM V YD Sbjct: 120 PQADASVKSGKWDRKTFVGVELYNKTLAILGMGRIGTEIARRAIAFGMRVLAYDPYLSAS 179 Query: 188 LGNATQ---VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + Q V+ L ++ +D ++LH+P TK M+ A+ ++ K G ++N +RG ++ Sbjct: 180 RARSLQVELVESLDLIIPQADFITLHMPLTAETKYMLNAERLAKTKKGVRIVNCARGGLI 239 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL +AL SK +A AA+DVF EP P SPL N++LTPH+G ST EAQE + Sbjct: 240 DEAALVEALKSKQVAAAALDVFEAEPL----PAESPLRGLPNLILTPHLGASTAEAQEGV 295 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVN 364 G+EVA ++ +G +AVN P + + G + + +N Sbjct: 296 GIEVAEQIRAALLSGEIRNAVNMPSIDAKTLAVVGPHIALGEKLGHFLSQIAAKRVESLN 355 Query: 365 I 365 I Sbjct: 356 I 356 Score = 49.6 bits (118), Expect = 2e-04, Method: Composition-based stats. Identities = 17/85 (20%), Positives = 35/85 (41%), Gaps = 1/85 (1%) Query: 325 VNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIE 384 VN V G + + +RPGV+ + + + VNIA L + + G + + Sbjct: 445 VNGRHVEAKPEGVL-FLFENRDRPGVVGHVGTLLGKHKVNIAGMSLSRNEEGGEALTLLN 503 Query: 385 ADEDVAEKALQAMKAIPGTIRARLL 409 D +E ++ + A +++ Sbjct: 504 LDSVPSEAIIKELTAGGDIHSVQVV 528 >UniRef50_B0TAQ8 D-3-phosphoglycerate dehydrogenase n=4 Tax=Clostridia RepID=B0TAQ8_HELMI Length = 526 Score = 446 bits (1148), Expect = e-124, Method: Composition-based stats. Identities = 113/370 (30%), Positives = 188/370 (50%), Gaps = 15/370 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 ++ L+ + + QK ++ L +AG ++ K L ++Q+ E I + + +RS T +T+ +I Sbjct: 1 MRVLVCDPISQKGIDVLTSAGDVAVDV-KLKLTEDQIVEIIAEYDAVVVRSETKITKRII 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA++L AIG +G + +D++AA ++GI V NAP NT + AEL + +L + R V A Sbjct: 60 EAADRLKAIGRAGVGVDNIDVEAATRKGIVVVNAPEGNTIAAAELTVAHILAIARNVGSA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 N G W++ E +GK LGI+G G IG+++ A + M V YD + Sbjct: 120 NLSLKGGKWDRSKYTGIELKGKTLGILGLGKIGSEVAKRARAFDMTVIAYDPYASVEKAK 179 Query: 191 --ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 V L + SD +++H+P+ T M+ A + ++MK G ++N +RG ++D A Sbjct: 180 SLGVTVTDLETVFRQSDFITVHMPKTKDTYRMISAAQFAIMKEGVRIVNCARGGIIDEQA 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L DA+ S +A A +DVF EP T SPL D V TPH+G ST+EAQ N+ ++V Sbjct: 240 LYDAIQSGKVAAAGLDVFEKEPCT-----DSPLFALDQVTATPHLGASTKEAQVNVAIDV 294 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVN-IAA 367 A +++ + +AVN P V + + + G + N I Sbjct: 295 AYDILRVLRGEAVSAAVNIPAVKQEMMTIFKPYLNLVEKMG------SYLGQTIGNRIEK 348 Query: 368 QYLQTSAQMG 377 + + Sbjct: 349 VAITFKGDVA 358 Score = 51.5 bits (123), Expect = 5e-05, Method: Composition-based stats. Identities = 19/76 (25%), Positives = 29/76 (38%) Query: 334 LHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKA 393 G L+ H ++P ++ L I E VNIA +L G V + D V Sbjct: 448 APEGHMLVVPHTDKPRIIGQLGTIIGEHNVNIAGMHLGRKDFGGNAVAILTIDGPVPAAV 507 Query: 394 LQAMKAIPGTIRARLL 409 L + I G + + Sbjct: 508 LTDLAKIDGVADVKYV 523 >UniRef50_A0LMX1 D-3-phosphoglycerate dehydrogenase n=1 Tax=Syntrophobacter fumaroxidans MPOB RepID=A0LMX1_SYNFM Length = 525 Score = 445 bits (1147), Expect = e-124, Method: Composition-based stats. Identities = 111/364 (30%), Positives = 182/364 (50%), Gaps = 11/364 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ +G+H+ L LRAA +++ E++K + D + +RSRT +T ++I Sbjct: 1 MKVLICDGMHEVGLSILRAAEGIDVDVPDQP-GAEEIKAMLPDYDAVIVRSRTRITAELI 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A +L IG G + +D+ AA+ RG V N P +N + AE I +L L R +P+A Sbjct: 60 ENAPRLKVIGRAGTGVDNIDVKAASARGALVMNTPGANATAAAEHTIAMMLALARHIPQA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKLPL 188 G W+K E + LGIIG G IG+ + A S+ M V +D + Sbjct: 120 TQSMREGRWDKKRFMGTELFHQTLGIIGLGKIGSIVADRALSMKMDVLGHDPYIIPEAAA 179 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + L +LL SD ++LH P T ++ + ++ KPG ++N +RG ++D A Sbjct: 180 ILGVEWVPLDELLARSDFLTLHTPSTSETVRILNRETLARTKPGVRILNCARGGLIDEQA 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L + L + H+ GAA+DVF EP P SPL + +NV+ TPH+G S+ +AQ N+ + Sbjct: 240 LYEFLLNGHVGGAALDVFEQEP-----PVDSPLLKLENVIFTPHLGASSYQAQANVARAI 294 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 A +++ Y G +AVNFP + + + + R L +L + + Sbjct: 295 ATQIVDYLLYGIIRNAVNFPSIRPQDYEKIKPYLVLAER---LGSLQGQVSTPIQRLEIT 351 Query: 369 YLQT 372 Y + Sbjct: 352 YSGS 355 Score = 43.8 bits (103), Expect = 0.011, Method: Composition-based stats. Identities = 14/75 (18%), Positives = 29/75 (38%), Gaps = 1/75 (1%) Query: 332 LPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAE 391 G L+ + ++PG + + VNIA +L + + I D + Sbjct: 447 EAELEGINLLIQNYDKPGTIGLIGTTLGSHQVNIANMHL-SRTPRDKAIAIIRLDNEAPP 505 Query: 392 KALQAMKAIPGTIRA 406 +A++ ++ P I Sbjct: 506 EAIETLRRHPSIISV 520 >UniRef50_A1RYE4 Glyoxylate reductase n=18 Tax=cellular organisms RepID=GYAR_THEPD Length = 339 Score = 444 bits (1144), Expect = e-123, Method: Composition-based stats. Identities = 101/341 (29%), Positives = 159/341 (46%), Gaps = 12/341 (3%) Query: 8 KDKIKFLLVEGVHQKALESLRAAGYTNIEFHKG-ALDDEQLKESIRDAHFIGLRSRTHLT 66 + K + + + L L+ + K E+L +IRD + + Sbjct: 1 MARPKVYVTRIIPEPGLSMLKECCDVVVHESKDWPPSREELLRNIRDKDALLCLLTDKID 60 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 +V++AA L I + +G + +D+ A KRGI V + P T +VAE +G +L + R Sbjct: 61 AEVMDAAPNLKVISTYSVGFDHIDIPEATKRGIYVTHTPGVLTDAVAEFTVGLILAVTRR 120 Query: 127 VPEANAKAHRGVWNK----LAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI 182 + EA+ G W+K E +GK +G++G G IG S + + +YDI Sbjct: 121 IVEADKIIRTGQWDKPWNPYFLTGPELKGKTIGLVGLGRIGVATAKRLSSFDVKILYYDI 180 Query: 183 ENKLPLGNAT---QVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINAS 239 E + + + L LL SD+VS+HVP T +++ + + MK + LIN + Sbjct: 181 ERRWDVETVIPNMEFTDLDTLLEKSDIVSIHVPLTKETYHLINEERLRKMKKTAYLINTA 240 Query: 240 RGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQE 299 RG VVD AL AL +AGAA+DVF EP P PL +FDNV+L PHI +T E Sbjct: 241 RGPVVDTEALVKALKEGWIAGAALDVFEQEPL----PPNHPLTKFDNVVLAPHIASATIE 296 Query: 300 AQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRL 340 A++ + A LI + VN + + ++ Sbjct: 297 ARQRMAELAARNLIAVLKGEMPPALVNKEVLKVRPLEKVKM 337 >UniRef50_A3UGW9 D-3-phosphoglycerate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=A3UGW9_9RHOB Length = 407 Score = 442 bits (1138), Expect = e-122, Method: Composition-based stats. Identities = 212/398 (53%), Positives = 273/398 (68%), Gaps = 4/398 (1%) Query: 14 LLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAA 73 LL+E VH A +L+ AG ++ G+ D QL+ I A +G+RSRTH+ +++AA Sbjct: 10 LLLENVHPDADNALQTAGPVTVKRLSGSPDRAQLESEIASASVLGIRSRTHVDAALLDAA 69 Query: 74 EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAK 133 ++L A+GCFCIGTNQVDL AAA+RG+PVFNAPF+NTRSVAEL + +++L+R +PE Sbjct: 70 KELQAVGCFCIGTNQVDLVAAAERGVPVFNAPFANTRSVAELTMASVIMLMRRIPEKMFA 129 Query: 134 AHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQ 193 RG W K A G+ E R KKLGIIGYG+IG QL ++A +LGM+VY+YDI KL GNA Sbjct: 130 IQRGEWLKTADGANEVRKKKLGIIGYGNIGAQLSVIASALGMHVYYYDIAPKLAHGNARP 189 Query: 194 VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDAL 253 + L D+L DVV+LHVP P TKNM+G +I+LMK G+ LIN +RG +VD+ AL DAL Sbjct: 190 MDTLDDILTECDVVTLHVPSTPRTKNMIGKDQIALMKHGAFLINQARGDLVDVDALADAL 249 Query: 254 ASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLI 313 S HLAGAA+DVFP EP + + F SPL NV+LTPHIGGST EAQ+ IGL+ AGKL Sbjct: 250 NSGHLAGAAVDVFPVEPKSKDEKFESPLTRCANVILTPHIGGSTLEAQQAIGLDAAGKLA 309 Query: 314 KYSDNGSTLSAVNFPEVSLPL--HGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQ 371 +Y GST AVNFPEV G R++ H NRPG L LN + G N+AAQ+LQ Sbjct: 310 RYLHEGSTTFAVNFPEVEPGPIQPGRTRILAPHRNRPGFLRRLNDAAEQAGANVAAQFLQ 369 Query: 372 TSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 T +GY V D+E ++ E L ++AI GTIRARL+ Sbjct: 370 TKGDLGYAVADLE--GELPEDFLDRVRAIDGTIRARLI 405 >UniRef50_A5G1V9 D-3-phosphoglycerate dehydrogenase n=3 Tax=Proteobacteria RepID=A5G1V9_ACICJ Length = 528 Score = 442 bits (1137), Expect = e-122, Method: Composition-based stats. Identities = 121/400 (30%), Positives = 190/400 (47%), Gaps = 10/400 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K L+ + + A++ + G K L +L+E I + + +RS T +T +++ Sbjct: 2 PKVLISDKLSPAAIDIFKRRGIDVT--VKTGLAPAELREIIGEFDGLAIRSATKVTRELL 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +AA L IG IG + VD+ +A RG+ V N P+ N + AE IG + L R +PEA Sbjct: 60 DAATNLKVIGRAGIGVDNVDVKSATARGVVVMNTPYGNAITTAEHAIGLMFALARELPEA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG- 189 +A G W K E GK LG+IG G+IG+ + A L M V YD Sbjct: 120 SASTKAGKWEKNRFMGVELTGKTLGLIGAGNIGSIVADRALGLKMRVLAYDPYLTEARAT 179 Query: 190 -NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + L +L +D ++LH P T+N++ + I+ KPG +IN +RG +VD A Sbjct: 180 TLGVEKADLDTVLARADFITLHTPLTEQTRNILSRESIARTKPGVRIINCARGGLVDEAA 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L DAL S H+AGAA+DVF EPA SPL NV+ TPH+G +T EAQEN+ L+V Sbjct: 240 LYDALKSGHVAGAALDVFEVEPAKE-----SPLFALPNVVCTPHLGAATTEAQENVALQV 294 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGV-NIAA 367 A ++ + G+ +A+N VS + G + + + Sbjct: 295 AEQISDFLLTGAVTNAINMASVSAEDAPRLKPYMELCQLLGSFAGQLTEARQGVIRKVGI 354 Query: 368 QYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRAR 407 +Y +A + + + ++ + + + AR Sbjct: 355 EYEGAAAHVNQRPLSAALFAGLLAPMMEGVNMVNAPVFAR 394 Score = 51.1 bits (122), Expect = 8e-05, Method: Composition-based stats. Identities = 23/74 (31%), Positives = 41/74 (55%) Query: 336 GGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQ 395 G L + ++PG + + I AE+G+NIA +L + + G V I DE + + AL Sbjct: 453 GRHMLYVTNRDKPGFIAQCSAILAEKGINIATFHLGRTEKGGDAVCLISIDETLPDDALA 512 Query: 396 AMKAIPGTIRARLL 409 A++A+P ++A + Sbjct: 513 AIRALPQVMQATQI 526 >UniRef50_Q2G4V7 D-3-phosphoglycerate dehydrogenase n=146 Tax=cellular organisms RepID=Q2G4V7_NOVAD Length = 540 Score = 441 bits (1136), Expect = e-122, Method: Composition-based stats. Identities = 125/396 (31%), Positives = 191/396 (48%), Gaps = 11/396 (2%) Query: 7 EKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLT 66 K K L+ + + A G EQL I + + +RS T +T Sbjct: 12 NMTKPKVLISDKMDPNAARIFTEMGCDV--DVITGETPEQLIARIGEYDGLAIRSSTKVT 69 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 + +++AA L IG IG + VD+ AA+ +G+ V N PF N+ + AE I + L R Sbjct: 70 KAILDAATNLKVIGRAGIGVDNVDIPAASAQGVVVMNTPFGNSITTAEHAIAMMFALARQ 129 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--N 184 +PEANA+ G+W K E GK LG+IG G+IG+ + A L M V +D Sbjct: 130 IPEANAQTQAGLWPKNGFMGVEVTGKTLGLIGAGNIGSIVASRALGLKMKVVAFDPFLTP 189 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + + + L LL +D ++LH P T+N++ + I+ K G +IN +RG +V Sbjct: 190 ERAVEMGVEKADLETLLAKADFITLHTPLTDQTRNILSRENIAKCKKGVRIINCARGGLV 249 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL DAL S H+AGAA+DVF TEPA SPL N + TPH+G ST EAQ N+ Sbjct: 250 DEAALKDALDSGHVAGAALDVFETEPAKE-----SPLFGTPNFICTPHLGASTTEAQVNV 304 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVN 364 L+VA ++ + G +A+N P +S R + G L + ++ + Sbjct: 305 ALQVAEQMADFLVTGGVTNALNMPSLSAEEAPKLRPYMALAEKLGSL--VGQLAHDNLTK 362 Query: 365 IAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAI 400 IA + +AQ+ I + ++ Q + + Sbjct: 363 IAIEVEGAAAQLNQKPITAAVLAGLMKQYSQTVNMV 398 Score = 49.6 bits (118), Expect = 2e-04, Method: Composition-based stats. Identities = 15/70 (21%), Positives = 30/70 (42%) Query: 340 LMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKA 399 L ++ + PG + + + + +NI +L G V+ + D V+E L+ + Sbjct: 468 LYIVNSDAPGFIGRIGTLLGQNTINIGTFHLGRREAGGEAVLLLSLDNPVSEDVLKEARE 527 Query: 400 IPGTIRARLL 409 I G + L Sbjct: 528 IQGVRVVKAL 537 >UniRef50_D1JIG3 D-3-phosphoglycerate dehydrogenase n=1 Tax=uncultured archaeon RepID=D1JIG3_9ARCH Length = 542 Score = 439 bits (1130), Expect = e-121, Method: Composition-based stats. Identities = 107/368 (29%), Positives = 182/368 (49%), Gaps = 13/368 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + ++ ++ LR G ++E L E L I + + +RS T +T+++I+ Sbjct: 12 KVLVTDNISEEGIKKLREFGDVDVELD---LSKEDLAACIANYDALVIRSGTTVTKEIID 68 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A ++L IG +G + +D++ A ++GI V N+P +N+ S AE LL + R +P AN Sbjct: 69 AGKRLKVIGRAGVGVDNIDVERATEKGILVVNSPEANSISAAEHTFAMLLSISRKIPAAN 128 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN- 190 G W + E GK LG IG G +G+++ A+ GM V +D Sbjct: 129 VSLKSGKWERKKHMGVEVNGKVLGTIGLGRVGSEVAKRAKGFGMRVVAHDPFISAAKAKE 188 Query: 191 -ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 + ++L +D ++LH P T +M+G E LMK G +IN +RG ++D AL Sbjct: 189 LGITLLGFKEVLATADFITLHTPLTKDTHHMIGKGEFELMKDGVRVINCARGGILDEDAL 248 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 +A+ + +AGAA+DVF EP N D L E + V++TPH+G ST EAQ + +A Sbjct: 249 KEAIKAGKVAGAALDVFEQEPPNNDD-----LLELEEVIVTPHLGASTTEAQRAAAVVIA 303 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQY 369 ++I N +A+N + L + + + G+L+ + I Sbjct: 304 DEVIGALSNKPVKNALNMLYLEEELMDSVKPYLVLAEKLGLLS---AQLIPKSRRIEQFN 360 Query: 370 LQTSAQMG 377 + ++G Sbjct: 361 VSYEGELG 368 Score = 45.0 bits (106), Expect = 0.005, Method: Composition-based stats. Identities = 14/75 (18%), Positives = 31/75 (41%) Query: 335 HGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKAL 394 G L+ ++P V+ + I + +NI + + G V+ + D VA + Sbjct: 466 PSGHMLICSFIDKPRVIGPVCTILGDHSINITGMRVGREKKEGEAVMVLNVDNPVAGDII 525 Query: 395 QAMKAIPGTIRARLL 409 + + + I +L+ Sbjct: 526 EDIMKVENLIDIKLV 540 >UniRef50_A2STQ1 D-3-phosphoglycerate dehydrogenase n=5 Tax=cellular organisms RepID=A2STQ1_METLZ Length = 527 Score = 437 bits (1125), Expect = e-121, Method: Composition-based stats. Identities = 118/372 (31%), Positives = 195/372 (52%), Gaps = 12/372 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K L+ + + + + L+ + K L +++L + I + + +RS T +T +I Sbjct: 3 FKVLVSDPLAAEGIAILKDFCEVD---EKADLSEDELVKIIGEYDALIVRSGTQVTARII 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA+K+ IG +G + +D +AA K+GI V NAP NT + E I ++ + R +P+A Sbjct: 60 EAADKMKYIGRAGVGVDNIDCEAATKKGIIVSNAPEGNTLAATEHTIAMMMAMARNIPQA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP--L 188 +A +G W + E GK LG++G+G IG ++ A++L M V YD Sbjct: 120 SASLKKGEWKRSKFMGNEMNGKVLGVVGFGRIGREVAKRAQALQMTVIAYDPFIPAEVGA 179 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 ++ +++L +DV+++H P PST +++ + I+ MK G +IN +RG ++D Sbjct: 180 AMGVEMMSVAELFTKADVITVHTPLIPSTTHLVNKESIATMKTGVRMINCARGGIIDEKD 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L DA+ S +AGAA+DVF TEP T SPL + D+V++TPH+G ST EAQ+N+ + V Sbjct: 240 LYDAIVSGKVAGAALDVFETEPPTE-----SPLLKLDSVIVTPHLGASTVEAQKNVAISV 294 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 A + I GS SAVN P V+ + + + G L A +I + Sbjct: 295 AHQCIDVLKGGSAKSAVNAPLVTPEVKSKIDPYALLAEKMGSLAA--QIADGAITEVEFA 352 Query: 369 YLQTSAQMGYVV 380 YL A + + Sbjct: 353 YLGEIADLKQNL 364 Score = 46.5 bits (110), Expect = 0.002, Method: Composition-based stats. Identities = 16/76 (21%), Positives = 36/76 (47%) Query: 334 LHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKA 393 + G ++ H NRPGV+ + I + VNI++ + ++ + D+ V+ + Sbjct: 450 VPSGYVILADHVNRPGVVGPVGMILGKHNVNISSMQVGGRNVGSESLMILAVDDIVSPEV 509 Query: 394 LQAMKAIPGTIRARLL 409 +Q + + G A+ + Sbjct: 510 MQEVASSDGITAAKFV 525 >UniRef50_A5FRL7 D-3-phosphoglycerate dehydrogenase n=5 Tax=Dehalococcoides RepID=A5FRL7_DEHSB Length = 526 Score = 436 bits (1123), Expect = e-121, Method: Composition-based stats. Identities = 127/388 (32%), Positives = 187/388 (48%), Gaps = 12/388 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K L+ + + L L+ ++ K L E+L I + + +RS+T +T D+I Sbjct: 2 KKVLVSDALSATGLAPLKEIAQVDV---KTGLKPEELISIIGEYDALLVRSQTQVTADII 58 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 NA +KL IG +G + +DL AA GI V NAP NT S E + +L + R +P A Sbjct: 59 NAGKKLQVIGRAGVGVDNIDLKAATGNGIIVVNAPTGNTISATEHTLALMLAMARHIPRA 118 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 NA G W + E +GK LGI+G G+IG+++ A +L M V YD + Sbjct: 119 NASLKSGQWKRNEFVGSELKGKTLGIVGLGNIGSEIAKRALALEMRVIGYDPFISMERAK 178 Query: 191 ATQVQ--HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 QV+ DLL +D ++LHVP TK ++G KE+ +MKP LIN SRG ++D A Sbjct: 179 KLQVELLPFEDLLKQADFITLHVPMTGQTKGLIGPKELEMMKPTVRLINTSRGGIIDEEA 238 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L A+ K + GAAIDVF EP T S L E DN+++TPH+G ST EAQE +V Sbjct: 239 LAKAVKEKRIGGAAIDVFSKEPCTE-----SCLFECDNIIVTPHLGASTAEAQELATSDV 293 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 ++I + AVN P +S G L ++++ N+ + Sbjct: 294 VKQVIDVFEGRPARYAVNAPYISAESLPVVGPFMPVARTVGSL--VSQLTDGHMKNVTIK 351 Query: 369 YLQTSAQMGYVVIDIEADEDVAEKALQA 396 Y A + + E + Sbjct: 352 YCGELAAYDTTALKALVLGGILEHISEE 379 Score = 42.7 bits (100), Expect = 0.024, Method: Composition-based stats. Identities = 19/80 (23%), Positives = 39/80 (48%) Query: 330 VSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDV 389 + + GG L H +RPG++ + KI + +NI+ +L G ++ + DE + Sbjct: 445 IDIVPTGGYFLFADHIDRPGLIGSAGKITGDADINISYMHLSRQKARGQALMILALDEPL 504 Query: 390 AEKALQAMKAIPGTIRARLL 409 EK Q + ++P +++ Sbjct: 505 PEKQRQQLLSLPDVQMVQVV 524 >UniRef50_A9WCW3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A9WCW3_CHLAA Length = 525 Score = 435 bits (1121), Expect = e-120, Method: Composition-based stats. Identities = 134/390 (34%), Positives = 193/390 (49%), Gaps = 18/390 (4%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ E + + L LR AG ++ LD L I + + +RS T +T +VI Sbjct: 3 RILVTEKIAAEGLAVLRQAGTVDVRLD---LDKPTLISIIGEYDALVVRSATKVTAEVIA 59 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A E+L IG G + +D++AA +RGI V NAP SN +VAEL IG L+ L R +P+A+ Sbjct: 60 AGERLRVIGRAGTGVDNIDVEAATRRGIIVVNAPASNNVAVAELTIGLLISLARRIPQAH 119 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN- 190 A G W + +E RGK LG++G G IG+++ A SL M V YD Sbjct: 120 ASLQSGRWARNDFVGWEVRGKTLGLVGLGRIGSEVARRARSLEMEVLAYDPVVSFDRAEQ 179 Query: 191 -ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 + L +L+ SDV+SLHVP ST+N+ + I MK G+ LINASRG +VD AL Sbjct: 180 LGVSLVTLDELVQRSDVISLHVPLIESTRNLFDQQRIMQMKRGAYLINASRGGIVDEVAL 239 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 +AL S HL GAA+DV+ EP P SPL ++ PHIG ST EAQ + G E+A Sbjct: 240 VEALNSGHLGGAALDVYNQEPL----PADSPLLGHPKIITVPHIGASTTEAQLSAGTEMA 295 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQY 369 ++ + G+ AVN P V+ + N +L L + Sbjct: 296 EGVVTALNGGTPRYAVNAPFVAPEAWNVLQPYL---NLGRLLGTLVMQL------VQEPV 346 Query: 370 LQTSAQMGYVVIDIEADEDVAEKALQAMKA 399 ++G + D++ + A Sbjct: 347 RSYDLELGGELADMDTQPVRLAVLQGLLAA 376 Score = 48.1 bits (114), Expect = 6e-04, Method: Composition-based stats. Identities = 15/64 (23%), Positives = 31/64 (48%) Query: 340 LMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKA 399 L+ H ++PG++ + ++ VNI+ Y+ A V+ + DE + ++ + Sbjct: 454 LITYHHDQPGMIGKVGQLLGAADVNISGMYVGRRAPRERAVMVLTLDEPAPPQVMEQIAT 513 Query: 400 IPGT 403 IPG Sbjct: 514 IPGI 517 >UniRef50_B8CX87 D-3-phosphoglycerate dehydrogenase n=1 Tax=Halothermothrix orenii H 168 RepID=B8CX87_HALOH Length = 527 Score = 435 bits (1120), Expect = e-120, Method: Composition-based stats. Identities = 109/340 (32%), Positives = 172/340 (50%), Gaps = 8/340 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + K +E L L E+ + I + + +RS T + ++ ++ Sbjct: 3 KVLVSDNISPKGIEILEQEADVTFN---PDLSREEFLDIIGEYDGLIVRSMTEVDKEALD 59 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A L IG G + +D++ A+KRGI VFN P NT S E IG +L L R +P+AN Sbjct: 60 KARNLKVIGRAGTGYDNIDIEEASKRGIIVFNTPTGNTISAVEHTIGMMLALSRNIPQAN 119 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 H G+W++ E +GK LGIIG G IG+++ + A++ GM V D Sbjct: 120 QALHEGIWDRKKYMGVEVKGKTLGIIGLGRIGSRVAVRAQAFGMKVIANDPYLPPEKAAK 179 Query: 192 TQVQ--HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 V ++L SD ++LH P T +++ KE ++MK +IN +RG VD AL Sbjct: 180 INVPLLGFKEVLKKSDYITLHTPLTDETYHILSHKEFAIMKDNVRIINCARGKNVDTQAL 239 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 ALA +AGAAIDV EP +P L D V++T H+GG+T EA +N+ + A Sbjct: 240 AKALAEHKVAGAAIDVHEVEPLPEDNPL---LKYQDRVIMTCHLGGTTTEAMDNVSIAAA 296 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPG 349 +++ +NG S +N P +++ + + N+ G Sbjct: 297 EQVLDVLNNGLPESPLNIPSINIQEYNKAKPYLNLVNKLG 336 Score = 43.0 bits (101), Expect = 0.021, Method: Composition-based stats. Identities = 12/60 (20%), Positives = 31/60 (51%) Query: 340 LMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKA 399 L+ ++++PGV+ + I + VNIA+ + + G ++ I+ D ++ ++ + Sbjct: 456 LVISYQDKPGVIGKVGSILGQDNVNIASMQVGRKSYGGQAIMIIQTDNKPSKATMEKINK 515 >UniRef50_A7IAB7 D-3-phosphoglycerate dehydrogenase n=11 Tax=cellular organisms RepID=A7IAB7_METB6 Length = 534 Score = 435 bits (1120), Expect = e-120, Method: Composition-based stats. Identities = 115/343 (33%), Positives = 182/343 (53%), Gaps = 10/343 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ + + ++ L L+ A ++ K L +++L I + + +RS T +T VI Sbjct: 5 RILVSDPLAEEGLVILKEAFTVDV---KTDLKEDELCGVIGEYDALIVRSGTEVTAKVIT 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A +KL IG +G + VD+DAA ++G+ V NAP NT + E + +L L R +P+AN Sbjct: 62 AGKKLRFIGRAGVGVDNVDVDAATRQGVIVANAPEGNTLAATEHTMAMMLSLARNIPQAN 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN- 190 A + W + E K LGI+G+G IG ++ A ++ M YD Sbjct: 122 ASLKKKEWKRSKFMGVELNEKTLGIVGFGRIGREVAKRANAMDMKCVAYDPFISKERAAQ 181 Query: 191 -ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 +V L++L ++DV+++H P TK+++ AK I+ MK G +IN +RG ++D AL Sbjct: 182 LGVRVMSLAELFTVADVITVHTPLIKETKHVINAKSIATMKDGVRIINCARGGIIDEAAL 241 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 DA+ S +AGAA+DVF TEP P SPL DNV++TPH+G ST EAQ+N+ ++VA Sbjct: 242 VDAIKSGKVAGAALDVFETEP-----PLESPLLSLDNVIVTPHLGASTVEAQKNVAIQVA 296 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLT 352 + ++ + GS VN P V + G Sbjct: 297 KQCVEVLNGGSAKYVVNAPIVPTEHAEVLEPFAELAEKMGRFA 339 Score = 48.8 bits (116), Expect = 4e-04, Method: Composition-based stats. Identities = 15/74 (20%), Positives = 34/74 (45%) Query: 335 HGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKAL 394 G ++ H ++PGV+ + I + +NIA + ++ + D +V E + Sbjct: 453 PEGYVIVSRHLDKPGVIGRASTILGKCNINIAGMQVGRINAGEEALMVLNVDSEVPEDVM 512 Query: 395 QAMKAIPGTIRARL 408 + ++++PG A Sbjct: 513 KEIRSMPGIFSATF 526 >UniRef50_A6UQN3 D-3-phosphoglycerate dehydrogenase n=4 Tax=Euryarchaeota RepID=A6UQN3_METVS Length = 523 Score = 435 bits (1120), Expect = e-120, Method: Composition-based stats. Identities = 120/389 (30%), Positives = 200/389 (51%), Gaps = 28/389 (7%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + +H+ A+E L+ AG I + E++K+ I+DA + +RS T +T+++I+ Sbjct: 3 KILITDPLHESAIEILKEAGEVEI---ATGISIEEIKQKIKDADALVVRSGTTVTKEIID 59 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A+E L I +G + VDLDAA ++G+ V NAP +++ SVAEL+ G +L R +P+A Sbjct: 60 ASENLKVIARAGVGVDNVDLDAATEKGVVVVNAPDASSISVAELMFGLMLSAARNIPQAT 119 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL--PLG 189 A +G W++ + E K LGI+G G IG Q+ A++ M + YD Sbjct: 120 ASLKKGEWDRKSFKGMEVYAKTLGIVGLGRIGQQVAKRAQAFEMNIVAYDPYIPENVASE 179 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 ++ + +L S+ ++LHVP TK+M+G + LMK +++IN +RG ++D AL Sbjct: 180 LGIKLLSVDELCAESEFITLHVPLTTKTKHMIGKTQFDLMKNNTIIINCARGGLIDENAL 239 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 DA+ + A +DVF EP T +PL + ++ TPH G ST+EAQ + G VA Sbjct: 240 YDAINCGKVKAAGLDVFEEEPPTK-----NPLISLNGLIGTPHQGASTEEAQLSAGTIVA 294 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQY 369 + +K S + VN P V + + G ++ QY Sbjct: 295 EQTVKILKGESAENVVNLPMVPTEKMKKLMPYLVLAEKMGSMS--------------IQY 340 Query: 370 LQTSAQMGYVVIDIEADEDVAEKALQAMK 398 L S + ++I D+A++ + +K Sbjct: 341 LDNSIDI----VEITYMGDLAKEKTEMLK 365 Score = 60.0 bits (145), Expect = 1e-07, Method: Composition-based stats. Identities = 16/68 (23%), Positives = 32/68 (47%) Query: 342 HIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIP 401 H +RPG++ + I E G+NIA + G+ ++ ++ D + E+ + +K I Sbjct: 454 IKHIDRPGMVGKVGLILGEHGINIAGMQVGRKEPGGHSIMFLDIDHMIPEEVMDEIKKIE 513 Query: 402 GTIRARLL 409 R + Sbjct: 514 NVRAVRAI 521 >UniRef50_UPI0001C41AB7 phosphoglycerate dehydrogenase SerA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41AB7 Length = 524 Score = 434 bits (1118), Expect = e-120, Method: Composition-based stats. Identities = 107/369 (28%), Positives = 186/369 (50%), Gaps = 16/369 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ + +++K +E+L+ ++ ++ E+L E+I + I +RSRT L +VI Sbjct: 1 MKALVADAINEKGIENLKEVCDVVVD---TSITPEELLETIGEYDAILIRSRTKLPAEVI 57 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A+ L I +G + VD++AA K+GI V NAP S + +VAE +G +L +R + A Sbjct: 58 EKADNLKIIARAGVGVDNVDVNAATKKGIMVVNAPESTSITVAEHTMGLILSTIRKIAIA 117 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + G W K A E R K LG+IG G IG+Q+ ++ M YD + Sbjct: 118 DKSTKAGKWEKKAFMGMELRNKTLGVIGMGRIGSQVVNRCKAFEMDAIAYDPYLPPEVAK 177 Query: 191 ATQ---VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + + D+L +D++++HVP P T++ + ++ +MK +L+ N +RG V+D Sbjct: 178 NMGVELYEDIEDVLTRADIITIHVPLTPETEHSISTEQFKMMKDTALIFNCARGGVIDED 237 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL +AL + + GA +DV+ EPAT + L E DN++ TPHI ST+EAQ + + Sbjct: 238 ALYEALVNGEILGAGLDVYEKEPAT-----NNKLFELDNIVCTPHIAASTKEAQRDAAII 292 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAA 367 VA ++I G + +N P ++ + G + + + I Sbjct: 293 VANEVITLFKGGMPKNIINMPRMNNSEFEETNDYLELCEKLGSF--ITQATSSP---INK 347 Query: 368 QYLQTSAQM 376 + ++ Sbjct: 348 LEITYKGEI 356 Score = 48.1 bits (114), Expect = 6e-04, Method: Composition-based stats. Identities = 23/117 (19%), Positives = 47/117 (40%), Gaps = 9/117 (7%) Query: 293 IGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLT 352 + T+E G A Y + VN V + G + +++ PG + Sbjct: 415 VAAKTKE-----GQMSAEG--TYLHEAKII-KVNGYWVDVKPEGNM-FIAKYKDIPGSIG 465 Query: 353 ALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 A+ F E+ +NI + + G ++ + DE +++A++ +K + A L Sbjct: 466 AIGTKFGEENINIGIMQVGRDSTGGEAIMILTLDERPSKEAVKKIKDLDNVSDATCL 522 >UniRef50_Q1PZY1 Similar to D-3-phosphoglycerate dehydrogenase (PGDH) n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PZY1_9BACT Length = 535 Score = 434 bits (1117), Expect = e-120, Method: Composition-based stats. Identities = 122/393 (31%), Positives = 186/393 (47%), Gaps = 17/393 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + L+ + + E L+ AG ++ K L +L I+ + +RS T LT V+ Sbjct: 10 MLVLIADDLPDVCNEILQNAGVEVLK--KTGLKPPELDAVIKMCDGVIVRSNTKLTAPVL 67 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +EKL AI +G + +D+ AA K+GI V N P N S AE I L L R VP+A Sbjct: 68 EKSEKLKAICRAGVGVDNIDVPAATKKGIVVMNTPAGNIISTAEHTIALLCSLSRFVPQA 127 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP--- 187 A G W K + GK GIIG G +G Q+ A +L M V YD Sbjct: 128 CASVKEGKWEKKKFTGQQLTGKTFGIIGLGRVGRQVAKRAAALEMKVIGYDPFITTEISS 187 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 N V++L DLL +D +++HV N TKN++ +KE SLMK G +IN +RG V+ Sbjct: 188 QYNIHIVKNLRDLLAQADYITIHVTLNKETKNLITSKEFSLMKKGVQIINCARGGVICEE 247 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 L +A+ + +AGAA+DVF EP P + L + + V+ TPH+G ST+EAQ + +E Sbjct: 248 DLYNAIKTGQVAGAALDVFEEEP-----PKDNKLLQLEEVIATPHLGASTEEAQYAVAIE 302 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGV-LTALNKIFAEQGVNIA 366 A ++ +AVN S + + + G LT +N I Sbjct: 303 AAEQMAAALTGKGYKNAVNLSPYSPEEYASLKSYLALAEKMGSFLTQIN------NAGIQ 356 Query: 367 AQYLQTSAQMGYVVIDIEADEDVAEKALQAMKA 399 + + ++ + I I D + +++ Sbjct: 357 TLDIVYTGEISHKNIRIVTDSLIVGLLKPSLEE 389 Score = 41.1 bits (96), Expect = 0.082, Method: Composition-based stats. Identities = 9/59 (15%), Positives = 21/59 (35%) Query: 345 ENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGT 403 ++PG + + + + +NIA G + + D + L +K + Sbjct: 469 RDKPGFIGQVGSLLGNKNINIAHMTFGRKEVGGNTISILNIDAVPPQDCLNEIKQLNHI 527 >UniRef50_B3DVF6 Phosphoglycerate dehydrogenase and ACT domains n=2 Tax=Verrucomicrobia RepID=B3DVF6_METI4 Length = 531 Score = 434 bits (1116), Expect = e-120, Method: Composition-based stats. Identities = 116/357 (32%), Positives = 175/357 (49%), Gaps = 8/357 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 L+ + + +K + L+A+ ++ K L +++L I D + +RS+T +T VI Sbjct: 6 HILIADPISKKGIAELQASAQLIVD-EKYGLKEDELARVIADYDGVIVRSQTKITRKVIE 64 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A +KL IG +G + VD+DAA ++GI V N P NT + AE LL L R V +A+ Sbjct: 65 AGKKLKVIGRAGVGIDNVDVDAATEKGIVVMNTPGGNTIATAEHTFSLLLALARNVAQAH 124 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 A G W + E GK LGIIG G +G ++ A + GM V +D Sbjct: 125 ASMQLGEWKRKNFEGIELYGKILGIIGLGRVGMEVAKRALAFGMKVKCFDPYLSPTKVKN 184 Query: 192 TQVQ---HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 QV+ L +L D +SLHVP T+ ++ + K G +IN +RG ++ I Sbjct: 185 LQVELVNSLDELFQDIDFLSLHVPLTQETEGIINKDNLKKCKRGIRIINCARGGLIRIAD 244 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L + L S +AGAA+DV+ EP P PL NV+LTPH+ ST EAQEN+G E+ Sbjct: 245 LEELLKSGWVAGAALDVYEPEPP----PADFPLRGLPNVVLTPHLAASTIEAQENVGTEI 300 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNI 365 A +I + +AVN P V + R + G+ + + + I Sbjct: 301 AAMVIDVLCHNIIRNAVNVPSVDPKILSILRPYMALGEKLGIFMSQWVVNRIDSLTI 357 Score = 46.9 bits (111), Expect = 0.001, Method: Composition-based stats. Identities = 18/84 (21%), Positives = 36/84 (42%), Gaps = 1/84 (1%) Query: 326 NFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEA 385 NF + + G L+ +++RPG++ + I E +NIAA L + + + Sbjct: 447 NFNPIEASMEGIL-LLLENKDRPGIVGKVGTILGEHSINIAAMSLARAKAGEKAISILNL 505 Query: 386 DEDVAEKALQAMKAIPGTIRARLL 409 D + L ++ I +L+ Sbjct: 506 DNIPSPDILVKIRNIEDIYNVQLI 529 >UniRef50_C4V410 Phosphoglycerate dehydrogenase n=4 Tax=Veillonellaceae RepID=C4V410_9FIRM Length = 565 Score = 432 bits (1113), Expect = e-120, Method: Composition-based stats. Identities = 109/389 (28%), Positives = 179/389 (46%), Gaps = 12/389 (3%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 ++K L +G+ + + L + + E+L + I D + +RS + +T DV Sbjct: 39 RMKILAADGISPEGIGLLTDYEVDV----RDKISHEELLDVIGDYDALMVRSASKVTADV 94 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 + A KL IG +G + +D+ AA +RGI V N+P NT + E + +L + R +P Sbjct: 95 LERAGKLKIIGRAGVGVDNIDVKAATERGIIVINSPGGNTIAATEHTVAMMLAMARNIPT 154 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 A+A H G WN+ A E RGK LG+IG G IG + A + M V YD Sbjct: 155 ADATMHAGQWNRKAYVGVELRGKTLGVIGMGRIGGGVAKRALAFDMNVIAYDPYINEERA 214 Query: 190 N--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 V L D++ +D +++H+P T+ M+ ++ MK G L+N +RG +++ Sbjct: 215 KALGVTVGTLDDIIEQADFITVHMPLTKETRGMISMAQMRRMKQGVRLVNCARGGIINEH 274 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 L +A+ +AGAAIDVF +EP SPL ++LTPH+G ST EAQ + ++ Sbjct: 275 DLAEAVREGIVAGAAIDVFESEPLAED----SPLRSVPGIVLTPHLGASTVEAQIGVSVD 330 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAA 367 VA + L+AVN VS + R + G + + Sbjct: 331 VAKGICAALRGEPVLAAVNMAPVSKEVMRVIRPYIALAEQLGCTA--CSLAEGPISQVEV 388 Query: 368 QYLQTSAQMGYVVIDIEADEDVAEKALQA 396 Y ++ + + + L++ Sbjct: 389 VYNGEITEVNTSFLTTAILKGMLNPILES 417 Score = 47.7 bits (113), Expect = 7e-04, Method: Composition-based stats. Identities = 23/93 (24%), Positives = 44/93 (47%), Gaps = 3/93 (3%) Query: 317 DNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQM 376 + +N V + H L+ H NRPGV+ + I G+NI++ + S + Sbjct: 471 EGRIVR--INRFRVDVDPHARI-LICPHINRPGVIGTIGSIMGAAGINISSMQVGKSDRK 527 Query: 377 GYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 G ++ + D D+++ L + A+ G A+L+ Sbjct: 528 GMNIMVLTIDHDISDDVLARVLAVEGIFDAKLV 560 >UniRef50_P35136 D-3-phosphoglycerate dehydrogenase n=12 Tax=Bacillales RepID=SERA_BACSU Length = 525 Score = 432 bits (1111), Expect = e-119, Method: Composition-based stats. Identities = 110/368 (29%), Positives = 187/368 (50%), Gaps = 13/368 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + L+ + + L+ L + + I A +++L + +RS T +TED+ Sbjct: 2 FRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDEL----HTFDALLVRSATKVTEDLF 57 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 N L +G +G + +D+D A K G+ V NAP NT S AE + L+R +P+A Sbjct: 58 NKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEHTFAMISSLMRHIPQA 117 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 N WN+ A E GK LGI+G G IG+++ A + GM V+ +D Sbjct: 118 NISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAFGMTVHVFDPFLTEERAK 177 Query: 191 ATQVQH--LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 V ++L +D++++H P TK ++ + I+ K G LIN +RG ++D A Sbjct: 178 KIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKTKKGVRLINCARGGIIDEAA 237 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +AL + H+AGAA+DVF EP ++ PL V+ TPH+G ST+EAQ N+ +V Sbjct: 238 LLEALENGHVAGAALDVFEVEPPVDNKLVDHPL-----VIATPHLGASTKEAQLNVAAQV 292 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 + ++++++ +SA+N P ++ + H + G L +++ E ++A Q Sbjct: 293 SEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGSL--VSQCMKEPVQDVAIQ 350 Query: 369 YLQTSAQM 376 Y T A++ Sbjct: 351 YEGTIAKL 358 Score = 61.1 bits (148), Expect = 8e-08, Method: Composition-based stats. Identities = 13/76 (17%), Positives = 35/76 (46%) Query: 334 LHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKA 393 G + H++ GV+ + +I + +NIA + + G ++ + D + +K Sbjct: 447 YPTGHLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKI 506 Query: 394 LQAMKAIPGTIRARLL 409 ++ + +P + +L+ Sbjct: 507 VKELTNVPDIVSVKLI 522 >UniRef50_Q1CYP3 D-3-phosphoglycerate dehydrogenase n=5 Tax=cellular organisms RepID=Q1CYP3_MYXXD Length = 417 Score = 431 bits (1110), Expect = e-119, Method: Composition-based stats. Identities = 206/401 (51%), Positives = 276/401 (68%), Gaps = 4/401 (0%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 + LL+E +H A E L A G+ +E AL ++L E ++ H +G+RS+T + Sbjct: 19 PFRALLLENIHPSAGEMLAAEGFQ-VERVSSALKPDELAERLKGVHLLGIRSKTTVPLAA 77 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 + AE L+AIG FCIGTNQVDL +A GIPVFNAPFSNTRSVAE+VI E+++L R + E Sbjct: 78 LEHAENLLAIGAFCIGTNQVDLTSANTHGIPVFNAPFSNTRSVAEMVIAEVIVLTRQLFE 137 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 + + H G W K+A GS E RGK LGIIGYGHIG+QLG++AE+LGM V ++D+ KLPLG Sbjct: 138 RSQEVHAGQWRKVATGSHEVRGKTLGIIGYGHIGSQLGVIAEALGMRVLYFDVMTKLPLG 197 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 NA L +LL SD V+LHVP P+T MMGA++I+ MK G+ LINASRGTVVDI AL Sbjct: 198 NAQPAVTLEELLGASDFVTLHVPALPTTHMMMGAEQIAQMKKGACLINASRGTVVDIDAL 257 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 AL S+HL GAA+DV+P EP +NSD F + L NV+LTPHIGGST+EAQ +IG EVA Sbjct: 258 ARALQSQHLGGAAVDVYPEEPESNSDGFVTALQGLPNVVLTPHIGGSTEEAQASIGKEVA 317 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPL-HGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 L+KY G++ AVNFP + PL G R++++H N PGVL +N+I ++ NI AQ Sbjct: 318 TSLLKYFKAGASTGAVNFPNIEAPLIPGTHRILNVHRNIPGVLRDINRIVSDLNANIHAQ 377 Query: 369 YLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 L T A +GY+++D+ D+DV+ +A+ + I+ R+L Sbjct: 378 VLSTDANIGYLLMDL--DQDVSTPVCEAIAGLETDIKTRIL 416 >UniRef50_UPI0001C430A3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Bacillus pseudofirmus OF4 RepID=UPI0001C430A3 Length = 540 Score = 431 bits (1109), Expect = e-119, Method: Composition-based stats. Identities = 121/382 (31%), Positives = 190/382 (49%), Gaps = 14/382 (3%) Query: 3 KVSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSR 62 K + K L+ + + Q+ L L N+ + +D+ E + + +RS Sbjct: 11 KTTERTAKYHILVSDAMSQEGLLPLLENA--NVHCVEAYVDE---VEDLTQFDALLVRSA 65 Query: 63 THLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLL 122 T +TE+++ L + +G + +DLDAA K G+ V NAP NT S AE + Sbjct: 66 TKVTEELLQKMPNLKIVARAGVGVDNIDLDAATKHGVVVVNAPDGNTISTAEHTFAMISS 125 Query: 123 LLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI 182 LLR +P+ANA G WN+ A E RGK LGI+G+G IGTQ+ A + M + +D Sbjct: 126 LLRKIPQANASIKAGEWNRKAFQGSELRGKTLGIVGFGRIGTQIAKRARAFEMSLLVFDP 185 Query: 183 ENKLPLGNATQVQ--HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 V L D+L SD++++H P TK ++G + I+ K G LIN +R Sbjct: 186 FLTKARAEKIGVTPASLDDVLAQSDIITVHTPLTKETKGILGMENIAKTKQGVFLINCAR 245 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G ++D AL LA+ H+AGAA+DVF EPA L EFDNV+ TPHI ST+EA Sbjct: 246 GGIIDESALKHYLANGHIAGAALDVFEEEPAQ-----DKELLEFDNVIATPHIAASTKEA 300 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAE 360 Q N+ +V+ ++I++ + +++N P +S ++ + + R G L L+++ Sbjct: 301 QLNVASQVSEEVIRFLEGQPATNSINLPTLSKEIYEKIQPYYDLTKRMGNL--LSQVMKT 358 Query: 361 QGVNIAAQYLQTSAQMGYVVID 382 I Y + + Sbjct: 359 PVQEIEVYYGGNITDLETSITT 380 Score = 60.8 bits (147), Expect = 9e-08, Method: Composition-based stats. Identities = 20/70 (28%), Positives = 35/70 (50%) Query: 334 LHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKA 393 + G L H ++PGV+ + ++ AE VNIA + + G ++ I D+ V E Sbjct: 463 VPQGHLLYIQHNDKPGVIGRIGQLLAEHDVNIATMQVGRKQEGGEAIMMITVDKTVEEDV 522 Query: 394 LQAMKAIPGT 403 L+A++ I Sbjct: 523 LKAVRKIEDI 532 >UniRef50_P73821 D-3-phosphoglycerate dehydrogenase n=40 Tax=Cyanobacteria RepID=SERA_SYNY3 Length = 554 Score = 431 bits (1109), Expect = e-119, Method: Composition-based stats. Identities = 109/369 (29%), Positives = 183/369 (49%), Gaps = 15/369 (4%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + Q ++ L+ ++ K L + ++ + + + I LRS T +TE +I Sbjct: 31 KVLVSDSIDQVGIDILKQVAQVDV---KTGLSEAEIIDIVPEYDAIMLRSATKVTEKIIQ 87 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A +L IG +G + +D+ AA ++GI V N+P NT + AE + ++ L R +P+AN Sbjct: 88 AGSQLKIIGRAGVGVDNIDVPAATRQGIVVVNSPEGNTIAAAEHALAMMMALARHIPDAN 147 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN- 190 W + E K LG++G G IG+ + +A+++GM + YD + Sbjct: 148 KSVKESKWERKQFIGTEVYKKTLGVVGLGKIGSHVAGVAKAMGMKLLAYDPFISQERADQ 207 Query: 191 -ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 + L L + +D ++LH+P+ P T N++ A+ ++ MKP + +IN SRG ++D AL Sbjct: 208 IGCTLVDLDLLFSEADFITLHIPKTPETANLINAETLAKMKPTARIINCSRGGIIDEEAL 267 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 A+ + + GAA+DVF EP S L EF NV+LTPH+G ST+EAQ N+ ++VA Sbjct: 268 VTAIETAQIGGAALDVFAQEPLGE-----SRLREFSNVILTPHLGASTEEAQVNVAVDVA 322 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQY 369 ++ SAVN P ++ + R G L G I Sbjct: 323 EQIRDVLLGLPARSAVNIPGLTPDVMEKLRPYLKLAETLGTLVGQL-----AGGRIDRLT 377 Query: 370 LQTSAQMGY 378 + + Sbjct: 378 VCLQGDLAE 386 Score = 49.2 bits (117), Expect = 3e-04, Method: Composition-based stats. Identities = 16/97 (16%), Positives = 33/97 (34%), Gaps = 12/97 (12%) Query: 314 KYSDNGSTL------SAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAA 367 NG +N P L +H + PG++ + + VNIA+ Sbjct: 457 ALLSNGEIRITDVDEFPINVP------PNNYMLFTLHRDMPGIIGKIGSLLGSFNVNIAS 510 Query: 368 QYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTI 404 + G ++ + D+ + + L + + G Sbjct: 511 MQVGRKIVRGDAIMALSLDDPLPDGLLSEITKVAGIR 547 >UniRef50_A7HM61 Glyoxylate reductase n=6 Tax=cellular organisms RepID=A7HM61_FERNB Length = 317 Score = 430 bits (1108), Expect = e-119, Method: Composition-based stats. Identities = 86/321 (26%), Positives = 158/321 (49%), Gaps = 11/321 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 ++ + + +K + L+ ++ + L E++ + A I + R + ++ I Sbjct: 1 MRVFVTYAIPEKGINMLKERFEVDVYTGEEFLSKEEMIKRAEYADAIVTQLRDPIDKEFI 60 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 + +K I + +G N +D++AA +RGI V N P T + A++ +L + R + E+ Sbjct: 61 YSLKKAKIIANYAVGYNNIDIEAAKERGIYVTNTPGVLTEATADIAFALILAVARRIVES 120 Query: 131 NAKAHRGV---WNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN--- 184 + G W ++ GK LG+IG G IG + A GM + +Y+ Sbjct: 121 DKFVREGKFVGWKPKLFLGYDLYGKTLGVIGMGRIGQAVARRALGFGMNIVYYNRNRLPE 180 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 ++ + ++ +L+ +SD +SLH P T +++ + I+ MKP ++L+N +RG VV Sbjct: 181 EIEKQYNAKYVNIDELVEISDYISLHTPLTKETYHLINKERIAKMKPNAILVNTARGPVV 240 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL +AL + +AGA DV+ EP L + DNV+L PHIG +T E ++ + Sbjct: 241 DEQALYEALKERRIAGAGFDVYENEPVLTPG-----LEKLDNVVLLPHIGSATYETRDKM 295 Query: 305 GLEVAGKLIKYSDNGSTLSAV 325 VA +++ D + V Sbjct: 296 SEIVAINVMEALDGKRPSNCV 316 >UniRef50_B2V7I1 D-3-phosphoglycerate dehydrogenase n=8 Tax=Aquificales RepID=B2V7I1_SULSY Length = 529 Score = 430 bits (1107), Expect = e-119, Method: Composition-based stats. Identities = 118/368 (32%), Positives = 182/368 (49%), Gaps = 9/368 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + K LE L ++++ + +L E I+D I RSRT +T++++ Sbjct: 3 KVLVTDDISPKGLEILSNDEEIDLDYQ-PEIKFNELLEIIKDYDAIITRSRTPVTKELLE 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AEKL IG +G + VDL+ A++RGI V N P +NT AE+ + L +LR + A+ Sbjct: 62 RAEKLKVIGRAGVGVDNVDLEEASRRGILVVNTPGANTIGAAEITMAHLYAVLRKLHLAH 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 G W + E GK +GIIG G++G+Q+ I ++ G V YD G+ Sbjct: 122 DSVKAGEWKRSKFMGEELDGKVVGIIGLGNVGSQVAIRCKAAGAKVIAYDPYIPKEKGDR 181 Query: 192 TQVQ---HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 V+ L +L+ +SD+++LH P T+NM+G KE LMK G IN +RG +VD A Sbjct: 182 LGVEIIDDLHELIKISDIITLHCPLTEETRNMIGKKEFDLMKKGVYFINCARGGIVDEDA 241 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L DA+ +AG +DVF EP D L EF N+ L+PHIG +T E+Q+N+ +++ Sbjct: 242 LYDAIQEGKIAGLGLDVFSKEPP---DERIRRLFEFPNISLSPHIGANTYESQDNVAIKI 298 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 A +I AVN P + + G L + I + Sbjct: 299 AQYVIAALKGQFVEVAVNAPFTITEGFENIKAYLELAEKLGSF--LTQYAGGHFTEINIE 356 Query: 369 YLQTSAQM 376 + Q Sbjct: 357 VRGSIKQH 364 Score = 48.4 bits (115), Expect = 5e-04, Method: Composition-based stats. Identities = 19/68 (27%), Positives = 36/68 (52%) Query: 340 LMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKA 399 LM +++ PGV+ L + A+ VNIA L + + ++ D+ + E+ L+ + Sbjct: 458 LMFENKDVPGVIGKLGTLLAKHNVNIAGFRLGRLEKGKIALGALQLDDRLNEEVLEEIHQ 517 Query: 400 IPGTIRAR 407 IP I+A+ Sbjct: 518 IPEIIKAK 525 >UniRef50_Q1IVI0 D-3-phosphoglycerate dehydrogenase n=3 Tax=Acidobacteria RepID=Q1IVI0_ACIBL Length = 531 Score = 430 bits (1107), Expect = e-119, Method: Composition-based stats. Identities = 114/357 (31%), Positives = 185/357 (51%), Gaps = 7/357 (1%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K ++ E + + A++ + N+ EQL E ++ A + +RS + ++ Sbjct: 1 MKIVVAEKIAKAAIDLFKQDPTWNVVTPDQVAQKEQLLEQLKGADALIVRSAVFVDAAML 60 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A++L IG +G + ++L+AA ++GI V N P +N +VAE IG +L L R +P A Sbjct: 61 EHADQLRVIGRAGVGVDNIELEAATRKGIAVMNTPGANAIAVAEHTIGLMLALARFIPRA 120 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 H G W K + E RGK LGI+G G IG ++ A S GM + +D + + Sbjct: 121 TETMHAGKWEKKSLQGTELRGKTLGIVGLGRIGLEVARRAASFGMTLVAHDPYVSPAIAH 180 Query: 191 A--TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 ++ ++L ++D ++LHV P T NM+ A ++ MK G ++N +RG ++D A Sbjct: 181 DAKIRLADRDEVLAVADYITLHVGLTPQTANMINATTLATMKKGVRIVNCARGELIDDAA 240 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +A+ S H+ GAA+DVF EP SP NV+LTPHIGGST EAQ+ +G+++ Sbjct: 241 LAEAVKSGHVGGAALDVFTEEPLKA-----SPYHGVPNVILTPHIGGSTAEAQDAVGVQI 295 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNI 365 A ++ Y G +AVN P ++ + R G L A + + I Sbjct: 296 AHQVRDYLQRGVVQNAVNMPSLTEQEYVALEPFITLGERLGSLLAQLAESRFEEIGI 352 >UniRef50_D1FX73 3-phosphoglycerate dehydrogenase-like protein n=1 Tax=Chironex fleckeri RepID=D1FX73_CHIFL Length = 520 Score = 429 bits (1105), Expect = e-119, Method: Composition-based stats. Identities = 101/377 (26%), Positives = 170/377 (45%), Gaps = 13/377 (3%) Query: 1 MAKVSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLR 60 MA ++++ + L+ + V + + ++ + E+L I+D + +R Sbjct: 1 MADLTIK----RVLISDKVDEVCKTIFESNKINV--DYRPGISKEELLAIIKDYDCLVVR 54 Query: 61 SRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGEL 120 S T +T +V +AA L +G G + +DL AA G+ V N P NT S AE + Sbjct: 55 SATKVTAEVFSAAPNLKLVGRAGTGVDNIDLKAATNNGVFVMNTPGGNTMSAAEHTCAMM 114 Query: 121 LLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 L R +P+ G W + E +GK LGIIG G IG ++ + ++ M Y Sbjct: 115 FSLARHIPQGYMSMQEGKWERSKFMGCELKGKTLGIIGLGRIGKEVALRMQACEMRTVGY 174 Query: 181 DI--ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINA 238 D + + L ++ + D +++H P P TK ++ AK K +IN Sbjct: 175 DPIVPKEAAAEFGVEFMELEEMWPIVDFITVHTPLIPQTKGLVNAKTFDKCKKTIRVINV 234 Query: 239 SRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQ 298 +RG ++D L DAL + AGA +DVF +EP + S L + V+ TPH+G ST Sbjct: 235 ARGGIIDESDLLDALNAGKCAGAGLDVFSSEPPSG---VVSELVKHPRVVCTPHLGASTA 291 Query: 299 EAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPG-VLTALNKI 357 EAQ + E+A +++ + + + VN P +S + G VL ++ Sbjct: 292 EAQVRVAKEIAEQIVDACNGKTAVGLVNAPAISEAGKEDVKPWMALGQALGAVLCKISPT 351 Query: 358 FAEQGVNIAAQYLQTSA 374 + VNI + + Sbjct: 352 LPK-LVNIKTRGEKPKG 367 >UniRef50_Q67TJ9 Phosphoglycerate dehydrogenase n=1 Tax=Symbiobacterium thermophilum RepID=Q67TJ9_SYMTH Length = 540 Score = 429 bits (1104), Expect = e-119, Method: Composition-based stats. Identities = 114/377 (30%), Positives = 184/377 (48%), Gaps = 17/377 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ E + + + LR ++ + E+L E I + + RS T +T +V+ Sbjct: 1 MKILVTEAISETGISLLRDEHEVDV----RKVTSEELLEIIPEYDALITRSETKVTAEVL 56 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +L +G +G + +D+ AA +RG+ V N P +NT S AE G L+ + R +P+A Sbjct: 57 ARGTRLKVVGRAGVGVDNIDVAAATERGVVVVNVPGANTYSTAEHAFGLLIAVARNIPQA 116 Query: 131 NAKA-HRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 + G W++++ E GK LGIIG G IG+++ + A + GM V YD Sbjct: 117 HHALAREGRWDRMSFVGTELHGKTLGIIGLGRIGSEVAVRARAFGMRVLAYDPYVPHSRA 176 Query: 190 NATQVQ---HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 V L LL D +++H + P + ++GA E++LMKP + ++N +RG +VD Sbjct: 177 EHLGVTLVPSLRGLLPEVDFLTIHAAKTPESARLIGAAELALMKPTARIVNCARGGMVDE 236 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL AL LAGAA+DVF EP T SPL NV++TPH+ ST EAQ+ G Sbjct: 237 EALYRALKEGRLAGAALDVFAAEPCT-----DSPLFGLPNVVVTPHLSASTAEAQDANGR 291 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALN-KIFAEQGVNI 365 +A +++ AVN P++ G +++ H L + + F I Sbjct: 292 YIAQYVLRALRGELVPEAVNLPQI---PRDGVQVVTDHLPLAETLGSFLAQAFPGHADRI 348 Query: 366 AAQYLQTSAQMGYVVID 382 Y A+ ++ Sbjct: 349 TVAYSGELAKHPTALLT 365 Score = 40.7 bits (95), Expect = 0.093, Method: Composition-based stats. Identities = 12/70 (17%), Positives = 27/70 (38%) Query: 334 LHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKA 393 L+ H ++PG++ A + +NIA +L G ++ ++ DE Sbjct: 457 APSRHMLVSQHRDQPGMVGRFGMALAARDINIAGLHLGRHQPRGMALMLLQIDEPAPPDL 516 Query: 394 LQAMKAIPGT 403 + ++ Sbjct: 517 VAELREAMAV 526 >UniRef50_A3DM01 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=5 Tax=Archaea RepID=A3DM01_STAMF Length = 311 Score = 429 bits (1104), Expect = e-118, Method: Composition-based stats. Identities = 130/311 (41%), Positives = 184/311 (59%), Gaps = 10/311 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ +H+KALE LR+AG+ + +++L E I+D I +RS+ ++ VI Sbjct: 3 KILVAAPLHEKALEKLRSAGFQIVYEEYP--SEDRLVELIKDVEAIIVRSKPKVSRRVIE 60 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AAEKL I +G + +DLDAA ++GI VFNAP + T+SVAEL IG ++ +LR + A+ Sbjct: 61 AAEKLKVIARAGVGLDNIDLDAANEKGIQVFNAPAAPTQSVAELAIGLMIDVLRKIAFAD 120 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILA-ESLGMYVYFYDIEN---KLP 187 K GVW K E RG LGIIG G IGT + +A GM + +YD+ + Sbjct: 121 RKMREGVWAKKQCLGHELRGIVLGIIGMGRIGTAVARIAYHGFGMKIIYYDVRRCPKDVE 180 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + L LL +D+VS+HVP PSTK+++ +++ LMK ++LIN +RG VVD Sbjct: 181 KELDAKCVDLETLLKTADIVSIHVPLVPSTKHLINEEKLRLMKKSAILINTARGGVVDTD 240 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL AL +AGA +DVF EP P PL + DNV+LTPHIG +T EAQE G+E Sbjct: 241 ALVKALKEGWIAGAGLDVFEEEPL----PPNHPLTKLDNVVLTPHIGANTVEAQERAGIE 296 Query: 308 VAGKLIKYSDN 318 V K+I++ Sbjct: 297 VVEKIIEFFKG 307 >UniRef50_A7HDB1 D-3-phosphoglycerate dehydrogenase n=3 Tax=Proteobacteria RepID=A7HDB1_ANADF Length = 528 Score = 429 bits (1103), Expect = e-118, Method: Composition-based stats. Identities = 121/357 (33%), Positives = 177/357 (49%), Gaps = 8/357 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ + + +A+ L+ AG K L +QL+ + D + +RS T +T +++ Sbjct: 4 RVLVSDDLSPEAVRILQEAGLEV--DVKVGLKPDQLERIVGDYDGLAVRSATKVTAQLLD 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A +L IG +G + VDL AA +RG+ V N P ++ +VAEL + +L L R V A Sbjct: 62 KAARLKVIGRAGVGVDNVDLAAATRRGVVVMNTPGGSSITVAELALSMILALSRHVAAAT 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN- 190 G W K E G+ LG++G G+IG+ L A +LGM V +D Sbjct: 122 GSVKAGKWEKKRFQGHELAGRTLGVVGIGNIGSVLVARAVALGMRVVAFDPFISAEAAAK 181 Query: 191 -ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 + L L +DVVS+HVP T++++ A + MK G+LL+N +RG +VD AL Sbjct: 182 LGASLVDLDTLWREADVVSIHVPLTDKTRHLVDATALGKMKKGALLVNCARGGIVDERAL 241 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 DAL S L GA +DVF EP P PL +NV+LTPHIG ST+EAQ + + VA Sbjct: 242 ADALRSGQLGGAGLDVFEQEPP----PADHPLYGLENVILTPHIGASTEEAQSAVAVAVA 297 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIA 366 +L Y G +AVN P + + + G L A V I Sbjct: 298 EQLADYLVRGVVRNAVNAPGLPPEVMEQLAPYLPLAQKLGALAAQLAPQGPSEVTIE 354 Score = 45.7 bits (108), Expect = 0.003, Method: Composition-based stats. Identities = 21/86 (24%), Positives = 34/86 (39%), Gaps = 1/86 (1%) Query: 324 AVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDI 383 VN V G L+ +++ PGV+ L A GVNIA L + Sbjct: 442 RVNAFRVEAVPDGNV-LLCENDDAPGVVGNLGTTLAAAGVNIAQISLSRLEDRSGAFAFL 500 Query: 384 EADEDVAEKALQAMKAIPGTIRARLL 409 D + + L+ ++ +P AR + Sbjct: 501 NVDSPPSAELLEKVRKLPHVRSARAI 526 >UniRef50_Q5WGX7 D-3-phosphoglycerate dehydrogenase n=8 Tax=Bacillaceae RepID=Q5WGX7_BACSK Length = 533 Score = 429 bits (1103), Expect = e-118, Method: Composition-based stats. Identities = 113/385 (29%), Positives = 192/385 (49%), Gaps = 15/385 (3%) Query: 1 MAKVSLEKD-KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGL 59 M +V+ K + L+ + + ++ L L A + + + + + Sbjct: 1 MNQVAEPKTAQFHILVADTMSEEGLLPLLEADHVEVTQASVDNAGP-----LEQYDALLI 55 Query: 60 RSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGE 119 RS T +TE++++ +L + +G + VD+ AA K G+ V NAP NT S AE Sbjct: 56 RSATTVTEELLSRMPRLKIVARAGVGVDNVDIQAATKHGVVVINAPDGNTISTAEHTFAM 115 Query: 120 LLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYF 179 + LLR +P+ANA G W++ A E RGK LGI+G+G IGTQL A++ M V Sbjct: 116 MCALLRNIPQANASVKSGKWDRKAYQGTELRGKTLGIVGFGRIGTQLAKRAKAFEMGVLV 175 Query: 180 YDIENKLPLGNATQVQ--HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLIN 237 YD + L +L+++D++++H P TK ++ + I+ KPG LIN Sbjct: 176 YDPFLTAERAEKLGIAQGELDHVLSVADIITVHTPLTKDTKGLLNMETIAKTKPGVFLIN 235 Query: 238 ASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGST 297 +RG ++D AL L + H+AGAA+DVF EPAT L +V+ TPHI ST Sbjct: 236 CARGGIIDEQALKHYLNNGHVAGAALDVFTEEPAT-----DKELIGHPSVVATPHIAAST 290 Query: 298 QEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKI 357 +EAQ N+ +V+ +++++ + L+++N P + ++ + + G + L+++ Sbjct: 291 KEAQLNVAAQVSQEVLQFLNGEPALNSINLPAMPKDVYEKIKPYYDLARTMGSV--LSQL 348 Query: 358 FAEQGVNIAAQYLQTSAQMGYVVID 382 I Y T+A+ V+ Sbjct: 349 MRIPVQEIEVFYSGTTAEQNTSVLT 373 Score = 47.7 bits (113), Expect = 8e-04, Method: Composition-based stats. Identities = 15/68 (22%), Positives = 31/68 (45%) Query: 336 GGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQ 395 G L H +RPGV+ + ++ A+ VNIA + + G ++ ++ D+ V + + Sbjct: 458 EGHILYIQHFDRPGVIGKMGQLLAKHDVNIATMQVGRKSAGGEAIMIVQVDKHVDQTVID 517 Query: 396 AMKAIPGT 403 + Sbjct: 518 GLLTFDEI 525 >UniRef50_C7R3H8 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=19 Tax=Bacteria RepID=C7R3H8_JONDD Length = 416 Score = 429 bits (1103), Expect = e-118, Method: Composition-based stats. Identities = 206/399 (51%), Positives = 260/399 (65%), Gaps = 4/399 (1%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K LL+E VH A+E L + GY I GALD+ +L E+++ H +G+RS+T +T VI+ Sbjct: 15 KALLLENVHPTAVEILSSHGYEVI-TRSGALDEAELIEALQGVHLLGIRSKTQVTRQVID 73 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A L+AIG FCIGTNQ+DL AAA+RG+ VFNAPFSNTRSV E+ I E++ L R +PE N Sbjct: 74 HAPDLIAIGAFCIGTNQIDLGAAAERGVGVFNAPFSNTRSVVEMAISEMISLTRRLPERN 133 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 H GVW+K A GS E RGK LGIIGYG+IGTQL +LAE+LGM V FYD KL LGNA Sbjct: 134 KAMHDGVWDKTADGSHEIRGKTLGIIGYGNIGTQLSVLAENLGMSVIFYDTAEKLALGNA 193 Query: 192 TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCD 251 + L +LL +DVV++HV P + GA++ + MK G++ +N SRG V+D AL D Sbjct: 194 RRATTLEELLGAADVVTIHVDGRPGNAGLFGAEQFAAMKRGAIFLNLSRGFVMDNEALRD 253 Query: 252 ALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGK 311 A+ S H+AGAA+DVFPTEP D F S L NV+LTPHIGGST EAQE+IG VA K Sbjct: 254 AIMSGHVAGAAVDVFPTEPKKRGDAFDSELRGLANVILTPHIGGSTLEAQESIGEFVANK 313 Query: 312 LIKYSDNGSTLSAVNFPEVSLPLHGGR-RLMHIHENRPGVLTALNKIFAEQGVNIAAQYL 370 L Y GST +VN P ++L G R+ +H N PGVL A+N A VNI Q L Sbjct: 314 LRDYVRTGSTTLSVNLPNLALETTGSITRIAFLHRNTPGVLAAVNNALATHNVNIDGQLL 373 Query: 371 QTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 T + GYVV D A V + L A+K I IR R++ Sbjct: 374 ATRGEFGYVVTD--AGSSVDPEVLNALKDIDQYIRIRVM 410 >UniRef50_O43175 D-3-phosphoglycerate dehydrogenase n=53 Tax=Bilateria RepID=SERA_HUMAN Length = 533 Score = 429 bits (1103), Expect = e-118, Method: Composition-based stats. Identities = 116/387 (29%), Positives = 176/387 (45%), Gaps = 11/387 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + + L+ G +E K L E+L ++D + +RS T +T DVIN Sbjct: 8 KVLISDSLDPCCRKILQDGGLQVVE--KQNLSKEELIAELQDCEGLIVRSATKVTADVIN 65 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AAEKL +G G + VDL+AA ++GI V N P N+ S AEL G ++ L R +P+A Sbjct: 66 AAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQAT 125 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--ENKLPLG 189 A G W + E GK LGI+G G IG ++ +S GM YD ++ Sbjct: 126 ASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSAS 185 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 Q L ++ + D +++H P PST ++ + K G ++N +RG +VD AL Sbjct: 186 FGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGAL 245 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 AL S AGAA+DVF EP P L + +NV+ PH+G ST+EAQ G E+A Sbjct: 246 LRALQSGQCAGAALDVFTEEP-----PRDRALVDHENVISCPHLGASTKEAQSRCGEEIA 300 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQY 369 + + S VN ++ + G L I Sbjct: 301 VQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMR--AWAGSPKGTIQVIT 358 Query: 370 LQTSAQMGYVVIDIEADEDVAEKALQA 396 TS + + + ++A + Sbjct: 359 QGTSLKNAGNCLSPAVIVGLLKEASKQ 385 >UniRef50_B7KZ64 D-3-phosphoglycerate dehydrogenase n=16 Tax=cellular organisms RepID=B7KZ64_METC4 Length = 535 Score = 428 bits (1102), Expect = e-118, Method: Composition-based stats. Identities = 124/404 (30%), Positives = 193/404 (47%), Gaps = 9/404 (2%) Query: 6 LEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 L + K K L+ + + A++ R G D E L I + +RS T + Sbjct: 4 LTQTKPKVLITDALSDAAVQIFRDRGIEVDFQPGLGKDKEALAAIIGQYDGLAIRSATKV 63 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 T+ ++ A +L IG IG + +D+ AA RG+ V N PF N+ + AE I + L R Sbjct: 64 TDKLLAQATRLKVIGRAGIGVDTIDVPAATARGVIVMNTPFGNSITTAEHAIALIFALAR 123 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE-- 183 +P A+A G W K E K LG++G G+IG + A L + V YD Sbjct: 124 QIPAADASTQAGKWEKNRFMGVELTAKTLGVVGCGNIGAVVADRAIGLKLKVIAYDPFLT 183 Query: 184 NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 + + L +LL +D+++LHVP T+N++ + ++ K G ++N +RG + Sbjct: 184 PERAFEIGVEKVELDELLARADIITLHVPLTDKTRNLLSEENLAKTKRGVRIVNCARGGL 243 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 VD AL AL S H+AGAA+DVF TEPA +PL NV+ TPH+G +T EAQEN Sbjct: 244 VDEIALRAALESGHVAGAALDVFVTEPAIE-----NPLFGHPNVICTPHLGAATSEAQEN 298 Query: 304 IGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGV 363 + L++A ++ Y +G+ +A+NFP +S + + G+ +G+ Sbjct: 299 VALQIAEQMADYLLSGAITNAINFPSISAEEAPRLKPFVALCEKLGLFLGQLTEAPIKGI 358 Query: 364 NIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRAR 407 I Y A M + A V LQ + + + AR Sbjct: 359 RIT--YEGAVAGMNTRALTSAAVTGVLRPILQEVNMVSAPVIAR 400 Score = 56.9 bits (137), Expect = 1e-06, Method: Composition-based stats. Identities = 26/122 (21%), Positives = 48/122 (39%), Gaps = 12/122 (9%) Query: 294 GGSTQEAQENIGLEVAGKLIK----YSDNGSTLSA----VNFPEVSLPLHGGRRLMHIHE 345 G S E+ I ++ ++G +N L + Sbjct: 414 GASDYESVVRITVDAEDMPRDAAGTVFNDGKPRVIEIRGINI----DAPFAPLMLYVRNH 469 Query: 346 NRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIR 405 +RPG + + + E GVN+A + A+ G + + D +V+ + L+A++AIP R Sbjct: 470 DRPGFVGSFGTVLGEAGVNLATFAMGREAEGGNAIAFVAVDAEVSPEVLKAIEAIPQVKR 529 Query: 406 AR 407 R Sbjct: 530 VR 531 >UniRef50_B6YWH0 Glyoxylate reductase n=95 Tax=cellular organisms RepID=GYAR_THEON Length = 334 Score = 427 bits (1100), Expect = e-118, Method: Composition-based stats. Identities = 94/326 (28%), Positives = 153/326 (46%), Gaps = 14/326 (4%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K K L+ + + ++ LR + + + E L E +RD + + +V Sbjct: 2 KPKVLITRKIPENGIKMLREHFEVEVWEDEHEISREVLLEKVRDVDALVTMLSERIDAEV 61 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 +AA +L + + +G + +D++ A K G+ + N P T + A++ LL R + E Sbjct: 62 FDAAPRLKIVANYAVGYDNIDIEEATKMGVYITNTPDVLTNATADMAWVLLLATARRLIE 121 Query: 130 ANAKAHRGVWNKLA-------AGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI 182 A+ G W K ++ G+ +GI+G+G IG + A+ GM + + Sbjct: 122 ADKFVRSGEWKKRGVAWHPLMFLGYDVYGRTIGIVGFGRIGQAIARRAKGFGMRILYNSR 181 Query: 183 ENKLPLGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 K + + L +LL SD V L VP T +M+ + + LMKP ++L+N +R Sbjct: 182 TRKPEVEKELGAEFMPLDELLKESDFVVLVVPLTKETYHMINEERLKLMKPTAILVNIAR 241 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G VVD AL AL +AGA +DVF EP + L DNV+L PHIG +T A Sbjct: 242 GKVVDTEALVKALREGWIAGAGLDVFEEEPYYHE-----ELFSLDNVVLAPHIGSATYGA 296 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVN 326 +E + VA LI + + + VN Sbjct: 297 REGMAELVARNLIAFKNGEVPPTLVN 322 >UniRef50_A6C9V4 Phosphoglycerate dehydrogenase n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C9V4_9PLAN Length = 541 Score = 427 bits (1098), Expect = e-118, Method: Composition-based stats. Identities = 115/392 (29%), Positives = 179/392 (45%), Gaps = 11/392 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ + + L+ L ++ G L E+++E+++ A I +RS T LTE+V+ Sbjct: 3 RVLITDNLSPAGLKILEDNPEIEVDIRSG-LSPEEVREALKSADGIIIRSATKLTEEVLK 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 +L AI +G + +D AA + GI V N P NT S AE I ++ L R + A Sbjct: 62 GQPRLKAIVRAGVGVDNIDRAAATREGIVVMNTPAGNTTSTAEQTIALMMALARNIGPAY 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 A G W + + GK L IIG G IG + A+ L M V YD Sbjct: 122 ATMKEGKWERKKLTGTQVAGKTLAIIGLGRIGLSVAHRAQGLEMKVIGYDPFMSAERAAE 181 Query: 192 TQ---VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + + +L+ D +++H P T++++ A+ I+ M+PG +IN +RG +V+ Sbjct: 182 YGIELYKEVDELVKHCDFLTVHTPLTDETRDLINAERIATMRPGVRIINCARGGIVNEDD 241 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L DAL S +AGAA DVF EP P L + N+L TPH+G ST EAQE + LE Sbjct: 242 LADALESGKVAGAACDVFTQEP-----PENRRLIDAPNMLATPHLGASTDEAQEMVALEA 296 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 A + + A+N VS + +R G+ L++ ++ Q Sbjct: 297 AEIISDFLTKNEIRHAINMIPVSGAEMADLKPHIELGHRLGLF--LSQQTKGSLKSVQIQ 354 Query: 369 YLQTSAQMGYVVIDIEADEDVAEKALQAMKAI 400 Y A +I + A +A I Sbjct: 355 YRGEVADKQTKLITSSFAAGLLSNAFEAEINI 386 Score = 45.7 bits (108), Expect = 0.003, Method: Composition-based stats. Identities = 15/72 (20%), Positives = 31/72 (43%), Gaps = 2/72 (2%) Query: 340 LMHIHENRPGVLTALNKIFAEQGVNIAAQYLQT--SAQMGYVVIDIEADEDVAEKALQAM 397 L++ H + PG++ + + VNIA L + G + + D +V E A+ + Sbjct: 457 LIYRHNDVPGLIGYIGTVLGNHNVNIAHMALGRLQNQPGGEAIAVLNVDGEVPEAAIAEV 516 Query: 398 KAIPGTIRARLL 409 + +L+ Sbjct: 517 SSHKDVSCVKLI 528 >UniRef50_A8ZXY9 D-3-phosphoglycerate dehydrogenase n=6 Tax=Deltaproteobacteria RepID=A8ZXY9_DESOH Length = 532 Score = 426 bits (1097), Expect = e-118, Method: Composition-based stats. Identities = 117/369 (31%), Positives = 175/369 (47%), Gaps = 14/369 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ + + + L ++ K L E+LK I + +RS T +T D++ Sbjct: 3 MKVLVSDTIDASGVSRLENESGFAVDV-KTGLPPEELKSIIGQYDALIIRSATKVTADIL 61 Query: 71 NA-AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 A A KL A+ IG + VD+ AA K G+ V N P N + AE I ++ L R +P+ Sbjct: 62 EAGAPKLKAVARAGIGLDNVDIPAATKHGVAVMNTPEGNVVTTAEHTIAMMMALTRNIPQ 121 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP-- 187 G W K E K LG+IG+G IG+ + A L M V +D Sbjct: 122 GTLSLRSGQWEKKKLQGREVFNKTLGVIGFGKIGSIVADRARQLKMNVIVFDPNIARTTI 181 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + L DL +D +++HVP+ T ++ MK G +++N +RG +VD Sbjct: 182 ENEGFEYVSLDDLFARADYITVHVPKLKQTVGLLNKAAFEKMKTGVMVLNCARGGIVDEA 241 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 L DAL S +A AA+DVF TEP P PL + DNV+ TPH+G ST+EAQ N+ Sbjct: 242 DLYDALMSGRVAAAALDVFVTEP-----PGEHPLLKLDNVIATPHLGASTKEAQVNVAEA 296 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAA 367 A ++I++ N + ++AVN P VS L +R G L A G NI Sbjct: 297 AAHQIIEFLKNNTVINAVNLPAVSGDLLEKLSPFTTLADRMGRLLAQFS-----GANITE 351 Query: 368 QYLQTSAQM 376 ++ + Sbjct: 352 IKIEYNGDF 360 Score = 41.5 bits (97), Expect = 0.064, Method: Composition-based stats. Identities = 14/85 (16%), Positives = 32/85 (37%) Query: 324 AVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDI 383 +N + + G + + ++PG + ++ GVNI + +I + Sbjct: 443 RINDFRLEMIPTKGHFAIIHNLDKPGAIGSIGTTLGTFGVNIERMQVGQQGDTLRNIIFL 502 Query: 384 EADEDVAEKALQAMKAIPGTIRARL 408 + + AL A+K +P + Sbjct: 503 RTGSRIPDDALAAVKELPLVKDVTV 527 >UniRef50_B5JEX5 D-3-phosphoglycerate dehydrogenase n=2 Tax=Verrucomicrobiales RepID=B5JEX5_9BACT Length = 545 Score = 424 bits (1092), Expect = e-117, Method: Composition-based stats. Identities = 104/362 (28%), Positives = 165/362 (45%), Gaps = 9/362 (2%) Query: 10 KIKFLLVEGVHQKALESLRA-AGYTNIEFHKG-ALDDEQLKESIRDAHFIGLRSRTHLTE 67 +K L+ + + ++ L+ G+ +E + D + E + A I +RS + +T Sbjct: 13 PMKILVADKISSTGVDFLKQQEGFEVVEAYGTFKEDYSKFLELAKGAAAIIVRSDSKVTR 72 Query: 68 DVIN-AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 +V AA L A+G +G + +D +AA G+ V N P NT + AEL +L R Sbjct: 73 EVFEVAAPTLKAVGRAGVGVDNIDSEAATDFGVVVMNTPGGNTIATAELTFTHMLCGARP 132 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL 186 VP+A G W++ G E K LG+ G G IG ++ A++ GM V YD Sbjct: 133 VPQAAQSMREGRWDRKIYGGSELFKKTLGVCGMGRIGAEVAKRAKAFGMKVLAYDPYLSG 192 Query: 187 PLGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + L +L SD +++H+P +T+ M+ I+ MK G L N +RG ++ Sbjct: 193 AKAETMGVEQVELDELFRESDYITVHMPLTDATRGMIDDAAIATMKDGVRLFNCARGGII 252 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL L S +A A +DV+ +EP P + LTPH+G ST+EAQE++ Sbjct: 253 DEDALLRGLESGKVAAAGLDVYTSEPPAED----HPFRSQKTLNLTPHLGASTEEAQESV 308 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVN 364 GLE+A + G +A+N P + + G L + V Sbjct: 309 GLEIAESVTSVLRGGGIRNAINMPSLDEQTLKTVGPYLELCSALGSLVQQLANEKVEKVK 368 Query: 365 IA 366 I Sbjct: 369 IT 370 Score = 49.2 bits (117), Expect = 3e-04, Method: Composition-based stats. Identities = 23/87 (26%), Positives = 46/87 (52%), Gaps = 1/87 (1%) Query: 324 AVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDI 383 ++N EV + HG L+ + + G++ + +I + GVNIAA L + G + Sbjct: 459 SINGREVEVEPHGSM-LVIANSDELGIVGKIGEIIGKDGVNIAAMSLSRNEVGGVALNIA 517 Query: 384 EADEDVAEKALQAMKAIPGTIRARLLY 410 D D+++ A+ +KAI +A++++ Sbjct: 518 SLDSDLSDAAMAEIKAIEAIKQAKVVH 544 >UniRef50_B9L167 Phosphoglycerate dehydrogenase SerA n=2 Tax=Thermomicrobia (class) RepID=B9L167_THERP Length = 745 Score = 424 bits (1092), Expect = e-117, Method: Composition-based stats. Identities = 116/352 (32%), Positives = 181/352 (51%), Gaps = 10/352 (2%) Query: 5 SLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTH 64 + + + ++ + + Q+A E L + D L E++R+A + +RS T Sbjct: 196 GAQPRRRRIVVSDVIDQRARERLASEADVI---EVDGRDKPALYEALREADALIVRSETQ 252 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 +T +++ A +L + G + +DL AA + GI V NAP +N S E + +L + Sbjct: 253 VTRELLAHAPRLRVVARAGTGVDNIDLQAATEAGILVLNAPGANAVSAGEHTVALMLAIA 312 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 R + +ANA H G W + F+ +GK +GI+G G +G+ + + + YD Sbjct: 313 RNLIDANATTHAGRWERKRFRPFDLKGKTIGIVGLGRVGSVVAQRLRAFECRLLGYDPYI 372 Query: 185 KLP--LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 + LL SD+V+ HVP P T++M+ A+ I+ MKPG+++IN +RG Sbjct: 373 TRERFAQLGVEPVDYETLLENSDIVTFHVPATPETRHMLDARAIARMKPGAIVINCARGE 432 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 VVD+ AL +AL S HLA A +DVFP EPA + SPL NV+LTPHIGGS++EA E Sbjct: 433 VVDVQALAEALKSGHLAAAGVDVFPEEPA-----YQSPLFGLPNVVLTPHIGGSSREALE 487 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTAL 354 +G +A + +AVN P SL RRL + E ++ L Sbjct: 488 AVGEIIATTTLAALRGEIVPNAVNLPAASLHAPELRRLTRVAEAAGHLIAVL 539 Score = 51.5 bits (123), Expect = 5e-05, Method: Composition-based stats. Identities = 19/72 (26%), Positives = 32/72 (44%) Query: 332 LPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAE 391 G L+ H +RPG++ + I VNIA + A+ G ++ + D+ + E Sbjct: 642 ERPLAGHMLITHHLDRPGIIGRIGTILGRYEVNIAGMQVGRRARGGEAIMVLNVDDPIPE 701 Query: 392 KALQAMKAIPGT 403 AL + IP Sbjct: 702 AALNEILQIPDV 713 >UniRef50_D0NEX4 D-3-phosphoglycerate dehydrogenase n=1 Tax=Phytophthora infestans T30-4 RepID=D0NEX4_PHYIN Length = 466 Score = 424 bits (1091), Expect = e-117, Method: Composition-based stats. Identities = 195/412 (47%), Positives = 274/412 (66%), Gaps = 9/412 (2%) Query: 4 VSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRT 63 V+ DKIK +L+E +H +A E GY +E HK A+ E+L DAH +G+RS+T Sbjct: 57 VTYPLDKIKVVLLENIHPRAKEVFEREGY-TVETHKRAMSGEELARVGGDAHILGIRSKT 115 Query: 64 HLTEDVIN----AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGE 119 L D N +L A+GCFCIGTNQV L +AA GIPVFNAPFSNTRSVAE + E Sbjct: 116 QLDPDFFNTVGWHEHRLWAVGCFCIGTNQVALPSAAATGIPVFNAPFSNTRSVAEKTLSE 175 Query: 120 LLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYF 179 ++ L R + + + H+G+W K A G+ E RG LGI+GYG IG+Q+ +LAE LGM V F Sbjct: 176 IIALHRKLFLRSTELHQGIWTKSATGAHEVRGTTLGIVGYGRIGSQVSVLAELLGMKVVF 235 Query: 180 YDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINAS 239 YD LPLGNA QV L +LL M+D V+LHVP P+TK M+ + I+ MK G+LL+N + Sbjct: 236 YDPVKCLPLGNARQVDTLEELLGMADAVTLHVPATPTTKKMINRETIAQMKDGALLVNNA 295 Query: 240 RGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQE 299 RGTV+DI A +A+ S +AG A+DVFP EPA N +PF +PL NV+LTPHIGGST+E Sbjct: 296 RGTVIDIDAAKEAVESGKIAGMAVDVFPKEPAKNGEPFDTPLRGLPNVILTPHIGGSTEE 355 Query: 300 AQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPL--HGGRRLMHIHENRPGVLTALNKI 357 AQ NI +EVA KL++Y ++GST ++ N PE+ + + R++H+H+N PGVL+ ++ + Sbjct: 356 AQGNIAVEVASKLVRYINDGSTTTSTNTPEIDMLPIRNNSMRILHMHQNVPGVLSKIHSV 415 Query: 358 FAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 ++ G+N+ +QYLQ+ + GY I +E ++ A+ + ++ I TI R + Sbjct: 416 LSDYGINVTSQYLQSDPRHGY--IALEVEKFHAKVVTRELEKIKETIFLRTI 465 >UniRef50_B2IJN8 D-3-phosphoglycerate dehydrogenase n=6 Tax=Bacteria RepID=B2IJN8_BEII9 Length = 529 Score = 424 bits (1091), Expect = e-117, Method: Composition-based stats. Identities = 120/395 (30%), Positives = 183/395 (46%), Gaps = 12/395 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + L+ + + + A+ + G D ++L E I + +RS T +T+ ++ Sbjct: 3 PRVLISDALSEAAVAIFKERGIEVDFQPDLGKDKDKLAEIIGQFDGLAIRSATKVTDKIL 62 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A L +G IG + VD+ AA +G+ V N PF N+ + AE I + L R +P A Sbjct: 63 EKATNLKVVGRAGIGVDNVDIPAATAKGVIVMNTPFGNSITTAEHAIALMFALARQIPSA 122 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKLPL 188 +A G W K E K LGIIG G+IG+ + L M V +D + L Sbjct: 123 DASTQAGKWEKNKFMGVEITAKVLGIIGCGNIGSIVAERGVGLKMRVIAFDPFLTPERAL 182 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + L DLL +D ++LH P P TKN++ A+ ++ K G +IN +RG +VD A Sbjct: 183 DLGVEKVELDDLLARADFITLHTPLTPQTKNILSAENLAKTKKGVRVINCARGGLVDEEA 242 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L L S H+AGAA DVF TEPA +PL NV+ TPH+G ST EAQEN+ L+V Sbjct: 243 LRKLLDSGHVAGAAFDVFITEPAKE-----NPLFGHPNVVCTPHLGASTSEAQENVALQV 297 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 A ++ Y G+ +AVNFP ++ + + G A I Sbjct: 298 AEQMSDYLTRGAISNAVNFPSITAEEAPKLKPFIALAEKLGSFAGQVIDSA-----IKKV 352 Query: 369 YLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGT 403 + ++G + I +A + + Sbjct: 353 TITYEGEVGQLKIKALTASAIAGILRPLLADVNVV 387 Score = 54.2 bits (130), Expect = 8e-06, Method: Composition-based stats. Identities = 21/95 (22%), Positives = 40/95 (42%), Gaps = 1/95 (1%) Query: 315 YSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSA 374 + D + A+N ++ + + +E++PG + + VNIA L Sbjct: 434 FHDGKPRIIAINDIKIDAAV-APVMIYVSNEDKPGFIGRFASLLGNASVNIATFALGRDR 492 Query: 375 QMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 + G + +E D V E +KA+PG + + L Sbjct: 493 EGGSAIALVEVDGAVPESVQNEVKALPGVKKVKAL 527 >UniRef50_B3RTC6 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RTC6_TRIAD Length = 520 Score = 422 bits (1087), Expect = e-117, Method: Composition-based stats. Identities = 106/349 (30%), Positives = 161/349 (46%), Gaps = 9/349 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + V K L A G L +L I + + +RS T +T +VI Sbjct: 6 KVLISDSVDPKCKSVLEAKGIEVT--LNTKLSPAELVAEIPNYDGLIVRSATKVTAEVIK 63 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A + L IG G + +D+ AA + G+ V N P NT S AE ++ L R VP+A Sbjct: 64 AGKNLKIIGRAGTGVDNIDIKAATECGVIVMNTPGGNTLSAAEHTCTLMVCLARQVPQAA 123 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN- 190 A G W++ E GK LGIIG G IG ++ +S G+ YD Sbjct: 124 ASMREGRWDRKKYMGIELMGKTLGIIGLGRIGREVATRMQSFGVRTVGYDPIVPAEAAKE 183 Query: 191 -ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 + L+DL D +++H P P T+ ++G + + K G +IN +RG ++D AL Sbjct: 184 FDVEFFELNDLWPECDFITVHTPLIPQTRGLLGDETFAKCKKGVRVINCARGGIIDEAAL 243 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 AL S AGAA+DVF EP P + L + NV+ H+G ST EAQ + +E+A Sbjct: 244 LRALQSGQCAGAALDVFEQEP-----PQNTELVQHPNVIPVCHLGASTVEAQSRVAVEIA 298 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIF 358 + + +++ S A+N + L + + R G L + Sbjct: 299 EQFVDFNEGKSLFGAINANAMVKALSPSAKSLVKLGERLGRLVEVLYGL 347 >UniRef50_C1TPS0 Lactate dehydrogenase-like oxidoreductase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TPS0_9BACT Length = 318 Score = 422 bits (1087), Expect = e-117, Method: Composition-based stats. Identities = 86/320 (26%), Positives = 144/320 (45%), Gaps = 9/320 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K + + + L L G + + L + I D + + + + Sbjct: 3 KVYVCHKIPEAGLNLLNGKVEYRCWDGDGPVPRDLLLKEISDVDGVITMLTEKVDSEFFD 62 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A + + + +G N VD++ A RG+ + N P T + A++ G L+ R EA Sbjct: 63 NAPNVKVVSNYAVGYNNVDVEEATSRGVKITNTPGVLTEATADIAFGLLVAASRRFTEAE 122 Query: 132 AKAHRGVWNKLAAG---SFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKL 186 G W E GK LG+IG+G IG + A GM V ++ Sbjct: 123 RYLRSGKWTCWHPTMLLGREIFGKTLGLIGFGRIGKAVARRASGFGMKVIYHTPSGGPAT 182 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 G+ + ++L SD +SLH P N T+ ++G KE+ MKP ++L+N SRG VVD Sbjct: 183 DQGDGPRWVSFEEILEKSDYLSLHCPLNDRTRGLIGKKELERMKPDAVLVNTSRGPVVDQ 242 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 +L ++L + A +DV+ EP + D PL +NV++ PHIG +T+EA++ + Sbjct: 243 TSLYESLRDGVIGAAGLDVYDEEPISLED----PLLSLENVVMLPHIGSATREARDAMAT 298 Query: 307 EVAGKLIKYSDNGSTLSAVN 326 A ++ + + VN Sbjct: 299 MAASNMLDVLEGKEPRNPVN 318 >UniRef50_B1HVJ4 Phosphoglycerate dehydrogenase n=5 Tax=Bacillales RepID=B1HVJ4_LYSSC Length = 535 Score = 422 bits (1086), Expect = e-116, Method: Composition-based stats. Identities = 104/366 (28%), Positives = 178/366 (48%), Gaps = 8/366 (2%) Query: 4 VSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEF-HKGALDDEQLKESIRDAHFIGLRSR 62 + I + + + + + LR ++ L E+L I D + +RS+ Sbjct: 1 MITATKTINVFIADPLSEDGIFPLRQEQDLDLNIIVDTGLAPEELMTKIADVDVLLVRSQ 60 Query: 63 THLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLL 122 T +T +VI AA+ L IG +G + +DL AA + GI V NAP NT S AE I + Sbjct: 61 TTVTREVIEAAKSLKLIGRAGVGVDNIDLTAATEHGIIVVNAPDGNTNSAAEHTIAMMTS 120 Query: 123 LLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI 182 L R +P+A G W++ + E + K LG++G+G IG ++ A+ M V YD Sbjct: 121 LARHIPQAFNTLKNGKWDRKSYVGVELKNKTLGVVGFGRIGVEVAYRAKGQRMNVMAYDP 180 Query: 183 ENKLPLGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 + ++ +D +++H P P T+N++ ++ ++MK G +IN +R Sbjct: 181 FLTDERAKELGVTKASVEEICEAADFITVHTPLLPETRNLINKEKFAMMKDGVRIINCAR 240 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G +++ L DA+ + +AGAA+DVF +EPAT L V+ TPH+G ST EA Sbjct: 241 GGIINEDDLYDAIVAGKVAGAALDVFVSEPAT-----DHKLLTLPQVIATPHLGASTIEA 295 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAE 360 QE++ ++V+ +IK+ G+ + VN P + L + G + Sbjct: 296 QESVAVDVSNDIIKFYKTGTVTNPVNMPSIPKELLAQVEPFFELAEKLGSFLSQVTTEPV 355 Query: 361 QGVNIA 366 + +N++ Sbjct: 356 KEINLS 361 Score = 42.7 bits (100), Expect = 0.026, Method: Composition-based stats. Identities = 14/75 (18%), Positives = 30/75 (40%) Query: 335 HGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKAL 394 G L + ++PG + + AE+ +NIA + + G V+ + D V + L Sbjct: 459 PQGHLLYIKNTDKPGAIGRVATKLAEKDINIATMQVGRAQVGGTAVMMLTIDNVVTNEDL 518 Query: 395 QAMKAIPGTIRARLL 409 + + + + Sbjct: 519 AFVAQLENIDEVKAI 533 >UniRef50_C0QYX0 D-3-phosphoglycerate dehydrogenase n=2 Tax=Brachyspira RepID=C0QYX0_BRAHW Length = 534 Score = 421 bits (1084), Expect = e-116, Method: Composition-based stats. Identities = 112/381 (29%), Positives = 191/381 (50%), Gaps = 17/381 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ + V++ + + + +++L + I + + +RS+T +T +I Sbjct: 1 MKVLITDKVNECVKDIIADVSEAVFL---PTMSEDELVKVIGEYDALMVRSQTKVTRKII 57 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A + L IG +G + +D++AA ++GI V N+P NT + +E I +L + R + A Sbjct: 58 EAGKNLKIIGRAGVGVDNIDVEAATEKGIIVVNSPDGNTIAASEHTIALMLAVSRNIVPA 117 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP--- 187 WN+ E GK LG++G+G IG ++ +A ++GM V YD Sbjct: 118 AVSTKEAKWNRDKFTGNELLGKTLGVMGFGRIGRKVVHIALAIGMKVIVYDPFATEEIVQ 177 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 A L + L D +SLH+P+ P T N++ + MK +++IN SRG +V+ Sbjct: 178 KAGAVYETSLDEFLPKLDYLSLHIPKTPETNNIINKDNLCKMKNTAIIINCSRGGLVNEE 237 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 L +AL + +A AA+DVF EP + P + DN++LTPH+G ST+EAQ N+ L+ Sbjct: 238 DLKNALENGTIAAAAVDVFVNEPKIETCPLVE--YKKDNLILTPHLGASTKEAQINVALD 295 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRR-LMHIHENRPGVLTALNKIFAEQGVNIA 366 VA ++ + G T SAVN P ++ + M I EN ++ N Sbjct: 296 VAKQIKQVLSGGYTESAVNIPSLNPEKLEPVKDYMKISENAGEMIMQ--------TANGK 347 Query: 367 AQYLQTSAQMGYVVIDIEADE 387 + L+ +AQ + +DI+ E Sbjct: 348 IKSLEITAQGDLINLDIQPLE 368 >UniRef50_O04130 D-3-phosphoglycerate dehydrogenase, chloroplastic n=43 Tax=Viridiplantae RepID=SERA_ARATH Length = 624 Score = 420 bits (1082), Expect = e-116, Method: Composition-based stats. Identities = 114/367 (31%), Positives = 179/367 (48%), Gaps = 10/367 (2%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K + L+ E + + + LR G + + L E LK+ + ++ + +RS T +T +V Sbjct: 82 KPRILVTEKLGEAGVNLLREFGDVDCSYD---LSPEDLKKKVAESDALIVRSGTKVTREV 138 Query: 70 INAAE-KLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 AA+ +L +G +G + VDL AA + G V NAP +NT + AE I L + R V Sbjct: 139 FEAAKGRLKVVGRAGVGIDNVDLQAATEHGCLVVNAPTANTVAAAEHGIALLASMARNVA 198 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL 188 +A+A G W + GK L ++G+G +GT++ A+ LGM V +D Sbjct: 199 QADASIKAGKWERSKYVGVSLVGKTLAVMGFGKVGTEVARRAKGLGMTVISHDPYAPADR 258 Query: 189 GNATQV--QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 A V ++ +D VSLH+P P+TK + + S MK G LIN +RG V+D Sbjct: 259 ARALGVDLVSFDQAISTADFVSLHMPLTPATKKVFNDETFSKMKKGVRLINVARGGVIDE 318 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL AL + +A AA+DVF EP + S L + +NV +TPH+G ST+EAQE + + Sbjct: 319 DALVRALDAGIVAQAALDVFCEEPPSKD----SRLIQHENVTVTPHLGASTKEAQEGVAI 374 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIA 366 E+A + + +AVN P V+ + + + G L + +I Sbjct: 375 EIAEAVAGALKGELSATAVNAPMVAPEVLSELTPYIVLAEKLGRLAVQLASGGKGVQSIR 434 Query: 367 AQYLQTS 373 Y Sbjct: 435 VVYRSAR 441 >UniRef50_Q49YF7 D-3-phosphoglycerate dehydrogenase n=55 Tax=Bacillales RepID=Q49YF7_STAS1 Length = 538 Score = 419 bits (1078), Expect = e-115, Method: Composition-based stats. Identities = 111/388 (28%), Positives = 186/388 (47%), Gaps = 11/388 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + + L+SL + LD+ +L I D + +RS+T +TE +I Sbjct: 3 KILVSDPISPEGLKSLIDHNDFEV-VIDTELDEAELINQIADYQALIVRSQTQVTEAIIE 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AA L I +G + +D+DAA K G+ V NAP NT S E + +L + R +P+A+ Sbjct: 62 AAPNLKVIARAGVGVDNIDVDAATKHGVIVINAPDGNTISATEHSMAMILSMARNIPQAH 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKLPLG 189 G W++ E K LG+IG G IG + A+S GM++ +D Sbjct: 122 QSLKDGKWDRKTYRGTELYNKTLGVIGAGRIGLGVAKRAQSFGMHILAFDPYLSEDKAKE 181 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 + ++ SD V++H P P TK ++G KP +IN +RG ++D AL Sbjct: 182 LNVTRATVEEIAEQSDFVTVHTPLTPKTKGIVGKAFFEKAKPNLQIINVARGGIIDEAAL 241 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 DAL + AAIDVF +EPAT SPL + +++TPH+G ST EAQE + + VA Sbjct: 242 VDALNQNQIQSAAIDVFESEPATE-----SPLVNHEKIIVTPHLGASTVEAQEKVAVSVA 296 Query: 310 GKLIKYSDNGSTLSAVNFPEVS-LPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 +++ +NG+ +A+N P+++ ++ + G + ++ + + + Sbjct: 297 NEIVDIFENGNVFNAINAPKMTYSEINDELKPYIELSQLTGEVG--IQLLEKAPRELHIK 354 Query: 369 YLQTSAQMGYVVIDIEADEDVAEKALQA 396 Y A ++ V ++ L Sbjct: 355 YEGDIALDDTSLLTRTLVSGVLKQDLAE 382 Score = 48.8 bits (116), Expect = 3e-04, Method: Composition-based stats. Identities = 19/73 (26%), Positives = 34/73 (46%) Query: 335 HGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKAL 394 +L+ H +RPG++ +I E G+NIA+ +L Q G ++ + D V + + Sbjct: 452 PERHQLVINHNDRPGIVGRTGQILGEYGINIASMHLGRINQGGNALMILSIDHPVTDDVI 511 Query: 395 QAMKAIPGTIRAR 407 + I G R Sbjct: 512 DGLYEIEGFNLIR 524 >UniRef50_Q4L766 D-3-phosphoglycerate dehydrogenase n=3 Tax=Staphylococcus RepID=Q4L766_STAHJ Length = 532 Score = 417 bits (1074), Expect = e-115, Method: Composition-based stats. Identities = 116/398 (29%), Positives = 188/398 (47%), Gaps = 14/398 (3%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K L+ + + L+SL N++ K LD++ L + I D + +RS+T +T+ V Sbjct: 2 KHNILVSDPISTDGLQSLLNHSDFNVDI-KTDLDEQSLLDIIGDYEGLIVRSQTQVTQQV 60 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I A L I +G + +D+DAA +GI V NAP NT S E + +L + R +P+ Sbjct: 61 IEKASNLKVIARAGVGVDNIDIDAATLQGILVINAPDGNTISATEHSVAMILAMARNIPQ 120 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 A+A WN+ A E K LG+IG G IG + +S GM V YD Sbjct: 121 AHASLKNKEWNRKAFKGVELYQKTLGVIGAGRIGIGVAQRLQSFGMKVLAYDPYLTEDKA 180 Query: 190 N--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 ++ + ++ +D V++H P P T+ ++ A S KP +IN +RG +++ Sbjct: 181 QQLGVKLATIDEIARQADFVTVHTPLTPKTRGIVNADFFSKAKPTLQIINVARGGIINED 240 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 L +AL + +A AA+DVF EP P SPL E D +++TPH+G ST EAQE + + Sbjct: 241 DLLNALNNNQIARAALDVFEHEP-----PTDSPLIEHDKIIVTPHLGASTIEAQEKVAVS 295 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVS-LPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIA 366 V+ ++I +NG+ AVN P++S + + G L A + + + Sbjct: 296 VSEEIIDILENGNVTHAVNAPKISFNDIDEITQQWIEIGELSGELAIQLIEGAPREIKV- 354 Query: 367 AQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTI 404 + + D+ V + Q + I Sbjct: 355 ----TFNGDVAKQETDLITRSIVKQILQQDLGDRVNII 388 Score = 48.1 bits (114), Expect = 7e-04, Method: Composition-based stats. Identities = 14/68 (20%), Positives = 32/68 (47%) Query: 335 HGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKAL 394 +L+ H ++PG++ ++ +NIA+ L + Q G ++ + D+ V E + Sbjct: 453 PNAYQLVSYHGDKPGMVGLTGQLLGRHNINIASMSLGRNIQGGQAMMVLSIDQPVTEDII 512 Query: 395 QAMKAIPG 402 + + G Sbjct: 513 NELYDVGG 520 >UniRef50_C1ZMC1 D-3-phosphoglycerate dehydrogenase n=2 Tax=Planctomycetaceae RepID=C1ZMC1_PLALI Length = 546 Score = 416 bits (1071), Expect = e-115, Method: Composition-based stats. Identities = 108/401 (26%), Positives = 186/401 (46%), Gaps = 13/401 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ + + L+ L+ ++ KG L ++++ ++ DA I +RS T LT +++ Sbjct: 3 RVLITDNLSPAGLKILKETPGIEVDLRKG-LTPDEVRVALHDADGIIIRSETKLTPEILK 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 +L AI +GT+ ++L AA + GI V N P NT S AE I ++ L R + A Sbjct: 62 DQPRLKAIVRAGVGTDNINLPAATREGIVVMNTPAGNTTSTAEHTIAMMMALSRNIAPAA 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE---NKLPL 188 +K GVW++ + + GK + I+G G IG + A L M V +D + Sbjct: 122 SKLRDGVWDRKSFTGTQLAGKSIAIVGLGRIGLAVARRAMGLEMKVLGFDPFMSVERAAE 181 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + + +++ D +++H P +P T N++GA+ ++ MK G +IN +RG +++ Sbjct: 182 QGIELYRDIDEMITKCDYLTVHTPLSPETTNLIGAERLAKMKKGVRIINCARGGIINEAE 241 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L A+ S H+ GAA+DVF EP P +PL + VL TPH+ ST EAQE + +E Sbjct: 242 LAQAIESGHIGGAALDVFVKEP----TPPDNPLLKLPQVLCTPHLAASTDEAQELVAVEA 297 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 A + + AVN +S R+ R GV+ + + Sbjct: 298 AEIMAGFLVRHEVRHAVNMAPISSAEMADMRIYLDLGLRLGVVLSQLNKSGVRSAK---- 353 Query: 369 YLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 L + + ++ A A+ + A +L Sbjct: 354 -LTFRGEAATKKTKLISNAFAAGLLSSALAENVNIVNAEML 393 Score = 43.0 bits (101), Expect = 0.018, Method: Composition-based stats. Identities = 20/79 (25%), Positives = 36/79 (45%), Gaps = 2/79 (2%) Query: 333 PLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQ--TSAQMGYVVIDIEADEDVA 390 G L++ H +RPGV+ + + VNIA + + G + + D + + Sbjct: 451 AYLDGTLLLYRHIDRPGVIGTIGTACGQHNVNIAHMAVGRERNEPGGEALAILNLDNEPS 510 Query: 391 EKALQAMKAIPGTIRARLL 409 +AL A++A P +LL Sbjct: 511 AEALAAVQANPAVTSVQLL 529 >UniRef50_C6PIV3 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Thermoanaerobacter italicus Ab9 RepID=C6PIV3_9THEO Length = 325 Score = 416 bits (1070), Expect = e-115, Method: Composition-based stats. Identities = 107/321 (33%), Positives = 158/321 (49%), Gaps = 10/321 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K LL E +H + L G I + +E L +RD I +RS+ +T+ +I Sbjct: 2 KKVLLSEEIHPDGRKILEEKGIEIITAPD--VKEETLISMVRDVEAIIVRSKAKITKGII 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A KL I G + +D++AA ++GI V N P N+ SVAE I +L L + + Sbjct: 60 ENAPKLKIISRTGAGVDNIDVNAATEKGILVCNLPAVNSLSVAEHTIAMILHLAKQLSLM 119 Query: 131 NAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIENKLPL 188 + G W + + S E GK LGI+G G+IG + LGM + YD K Sbjct: 120 DQAVRNGNWEMRNSNISVEVEGKTLGIVGMGNIGILVAKKCHDGLGMKIVAYDPYVKEKF 179 Query: 189 GNATQ--VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + V L +L SD V+LH P+ P T+ M+ + I MKP + LIN +RGTV+D Sbjct: 180 KDYDYRFVDSLEELFKESDFVTLHCPDIPETRGMITRELIYSMKPTAYLINVARGTVIDE 239 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL +AL K +AGA +DVF EP + + L +NV+L+PH T+EA + + Sbjct: 240 QALIEALKEKRIAGAGLDVFQQEPPSRDN----ELLRLENVILSPHSAALTKEATVRMAV 295 Query: 307 EVAGKLIKYSDNGSTLSAVNF 327 E +I Y + N+ Sbjct: 296 EAVQAVIDYFEGRQPKYIYNY 316 >UniRef50_B6KF90 D-3-phosphoglycerate dehydrogenase, putative n=3 Tax=Toxoplasma gondii RepID=B6KF90_TOXGO Length = 604 Score = 416 bits (1070), Expect = e-115, Method: Composition-based stats. Identities = 122/421 (28%), Positives = 201/421 (47%), Gaps = 36/421 (8%) Query: 1 MAKVSLEKD-----KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAH 55 MA+ + +K + + L+ + + Q ++ L + + + L +E+L + + Sbjct: 1 MAEATAQKRQKKHGRFRVLVCDPIDQAGMDILSSFADVDTKL---KLSEEELCRVVGNYD 57 Query: 56 FIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAEL 115 + +RS T +TE +I +KL IG +G + V +DAA +GI V N+P NT + AEL Sbjct: 58 GLMVRSGTTVTEKIIKHGQKLKIIGRAGVGVDNVCVDAATAQGIFVVNSPNGNTMAAAEL 117 Query: 116 VIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGM 175 +G ++ L R +P+A+A RG W + + K +GIIG G +GT + + +LGM Sbjct: 118 TLGLMMALARKIPQADASVSRGEWTRSKFMGRQLNQKTIGIIGLGQVGTHVARVCTALGM 177 Query: 176 YVYFYDIENKLPLGNATQV--QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGS 233 V YD A L LL SD ++LHVP T++++ A ++ L+K + Sbjct: 178 EVLAYDPFINEEKAKAVGCRNVALETLLASSDFITLHVPLLDKTRHLINADKLKLIKKDA 237 Query: 234 LLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFD----NVLL 289 +INASRG V+D A+ +AL + LAGAA+DVF E +PL + N++L Sbjct: 238 CIINASRGGVIDEKAVAEALMANELAGAALDVFEEE---KEFSKDNPLIQAKANGRNIIL 294 Query: 290 TPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPG 349 TPHIG ST EAQ N+ ++VA + + G SAVN V + + Sbjct: 295 TPHIGASTLEAQHNVAVDVALQFREALLGGLPQSAVNLQCVRSQQ------LVSLVHLAE 348 Query: 350 VLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 +L L ++ + +L+ + D+ + A G +R R Sbjct: 349 ILGRLCSKLVDEP--VETLHLKIRGSVDSANADVLL-----------LSAAQGVLRTRCD 395 Query: 410 Y 410 + Sbjct: 396 H 396 >UniRef50_C1SGT4 D-3-phosphoglycerate dehydrogenase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SGT4_9BACT Length = 544 Score = 415 bits (1069), Expect = e-114, Method: Composition-based stats. Identities = 108/386 (27%), Positives = 181/386 (46%), Gaps = 15/386 (3%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K K L+ + + Q + L++ ++ G + + LK+ I + I RS T +T ++ Sbjct: 3 KYKVLITDHISQDGVNILKSDKDIEVDIQAGIKNPD-LKKIIGNYDAIITRSGTTVTAEL 61 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I KL IG +G + VD++AA+ +GI V NAP NT + EL +G +L ++R +P Sbjct: 62 IENPGKLKIIGRAGVGLDNVDIEAASMKGIIVMNAPTGNTLAACELTMGMMLSVVRKLPL 121 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 AN G W++ + K L ++G G IG + ++ M V YD K Sbjct: 122 ANQVTKSGEWDRKRFMGIQLYQKTLAVVGLGRIGGNVAKRCKAFDMKVVAYDPYIKKSRA 181 Query: 190 NATQVQ---HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + V+ L + ++ +D+++ H P TKN++ EI+ MK G ++IN +RG +V+ Sbjct: 182 ESLGVELCNSLEEAISQADIITFHTPLTDETKNLITKDEIAKMKDGVVIINCARGGIVNE 241 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 L DA S + A +DVF +EP P P + +N+ +TPHIG +T E Q + + Sbjct: 242 LDLVDACKSGKVTAAGLDVFMSEP-----PVNHPFFDVENIYVTPHIGANTAEGQYGVAV 296 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGR-RLMHIHENRPGVLTALNKIFAEQGVNI 365 +A +++ S +AVN P + L + + EN + L K E I Sbjct: 297 IIAEQVVNALHGRSYKNAVNIPFMKTQLPEDMQKYFELLENIGHMAAQLTKGRPE---RI 353 Query: 366 AAQYLQTS--AQMGYVVIDIEADEDV 389 Q + G D + Sbjct: 354 EIQMVGHKFEEDFGERTFDTPFNFQP 379 Score = 42.3 bits (99), Expect = 0.036, Method: Composition-based stats. Identities = 16/73 (21%), Positives = 31/73 (42%), Gaps = 3/73 (4%) Query: 340 LMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTS---AQMGYVVIDIEADEDVAEKALQA 396 L + +RPG++ + I + +NIA L + V + D V L Sbjct: 470 LYFNNLDRPGIIGKVGTILGKHSINIADFDLARNVKEDGEADAVAFVRVDSKVPAGVLDE 529 Query: 397 MKAIPGTIRARLL 409 + A+ G + A+++ Sbjct: 530 ILALDGMLEAKVI 542 >UniRef50_UPI0001C31769 D-3-phosphoglycerate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31769 Length = 541 Score = 415 bits (1068), Expect = e-114, Method: Composition-based stats. Identities = 121/379 (31%), Positives = 190/379 (50%), Gaps = 16/379 (4%) Query: 4 VSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRT 63 ++ E +++K L+ E + ++ LR ++ DE+ + + + H I +RS T Sbjct: 1 MTAETNRLKILVKEKLADSGVDLLREHFDVDL---GADWSDEEFRSRLPEYHGILIRSAT 57 Query: 64 HLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLL 123 LTE+ I L IG +G N VD+ AA +RGI V NAP SN + AE + LL L Sbjct: 58 KLTEEYIALGTNLRVIGRAGVGVNNVDVPAATRRGIVVANAPQSNVVTAAEHTMALLLSL 117 Query: 124 LRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE 183 R VP+A+ W + G E K LG++G+G IG + A+ GM V +D Sbjct: 118 ARNVPQAHRSLTDHRWERSKFGGVEVYEKTLGVVGFGRIGQLVAERAKGFGMKVVAFDPF 177 Query: 184 NKLPLGNATQVQHLS---DLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 V+ D+ ++D +++H+P P T+ + A+ + MK G ++N +R Sbjct: 178 VGAERYRDLGVEKADTSADVYKVADFITIHLPVTPETQGWLNAEAFAQMKDGVRIVNCAR 237 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCE-FDNVLLTPHIGGSTQE 299 G +VD AL DAL S +AGAA+DVFP+EP T PL + + NV++TPH+G ST E Sbjct: 238 GELVDDAALKDALDSGKVAGAALDVFPSEPIT-----DYPLFDGYANVVVTPHLGASTAE 292 Query: 300 AQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFA 359 AQ+ G++ A ++I G+ +AVN P ++ VL L A Sbjct: 293 AQDRAGVQTAEQVIAALTGGTVTTAVNIPAIAAEDMEVLGPFVPL---CQVLGKLAVSLA 349 Query: 360 EQGVNIAAQYLQTSAQMGY 378 + G +I L+ ++G Sbjct: 350 D-GSSIDRLELEFFGRIGE 367 >UniRef50_A5IMH3 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=7 Tax=cellular organisms RepID=A5IMH3_THEP1 Length = 308 Score = 413 bits (1062), Expect = e-114, Method: Composition-based stats. Identities = 101/311 (32%), Positives = 161/311 (51%), Gaps = 5/311 (1%) Query: 6 LEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 ++ + + + + + ++A + L + + L+ ++L + I + + +RS T + Sbjct: 1 MKMARYRVHVNDPLDKEATQLLMSKDELEVT--SEHLEKDELMKIIPEIDVLVVRSATKV 58 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 T D+I A + L I IG + +D+ A ++GI + N P ++ SVAEL +G +L R Sbjct: 59 TADIIEAGKNLKIIARAGIGLDNIDVQKAKEKGIKILNTPGASAPSVAELAMGLMLACAR 118 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 + A G W K A E GK LG+IG+G+IG ++ A + GM + YD K Sbjct: 119 HIARATISLKEGKWEKKALNGKELLGKTLGLIGFGNIGQEVAKRALAFGMKIIAYDP-AK 177 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 + L L SD +SLHVP ST++++ + I+ MK G +++N +RG +D Sbjct: 178 PATDLPVEYVDLDTLFRESDFISLHVPLTESTRHIINRESIAKMKDGVIIVNTARGGTID 237 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL +AL S + A +DVF EP T D L DNV+ TPHIG ST EAQ +G Sbjct: 238 EEALYEALVSGKVYAAGLDVFEVEPPT--DEIRRKLLNLDNVVATPHIGASTDEAQNRVG 295 Query: 306 LEVAGKLIKYS 316 E+ K+ K Sbjct: 296 TELVEKIFKEL 306 >UniRef50_A5GES6 D-3-phosphoglycerate dehydrogenase n=12 Tax=Desulfuromonadales RepID=A5GES6_GEOUR Length = 541 Score = 413 bits (1062), Expect = e-114, Method: Composition-based stats. Identities = 112/370 (30%), Positives = 183/370 (49%), Gaps = 10/370 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K ++ + V Q+ LE L+ ++ G L E+L I D I RS T + +D++ Sbjct: 1 MKVIVTDEVAQEGLELLKQDPRVELDIRLG-LKKEELLAIIGDYEVIITRSGTTVDKDLL 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +A +KL + +G + VD+D A+ +G+ V NAPF NT S AE + LL R + +A Sbjct: 60 DAGKKLKMVARAGVGIDNVDIDYASSKGVIVVNAPFGNTNSAAEHAMALLLSFCRNITKA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKLPL 188 NA G W + E +GK G+IG G +G ++ ++ V D K Sbjct: 120 NASLKSGEWKRAPFTGVELKGKTAGVIGLGKVGGRVATRLKAFECDVLGCDPYIAVKRAH 179 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 ++ ++ D+++ H P N T+NM+G KEI++MK G +LINA+RG +++ A Sbjct: 180 DLGVKLVSHEEIYKNCDIITFHTPLNEETRNMVGEKEIAMMKDGVILINAARGGIINEQA 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +AL + GAA+DV+ EP + L D +++TPH+G +T EAQ N+ ++V Sbjct: 240 LLNALKGGKVFGAAMDVWSEEPPKSET--LKELISQDKLVVTPHLGANTFEAQINVAVDV 297 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 + +++ Y D +AVN P + L R N VL E N+ Sbjct: 298 SKEILNYLDEQPLENAVNIPRFDMALMDQMRPFL---NLMSVLCDFGVQLVE--SNLEKV 352 Query: 369 YLQTSAQMGY 378 S + + Sbjct: 353 TFSYSGNIAH 362 Score = 55.0 bits (132), Expect = 5e-06, Method: Composition-based stats. Identities = 14/77 (18%), Positives = 33/77 (42%) Query: 334 LHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKA 393 L+ +E+RPG++ + I +NIA+ L + G ++ + D V + Sbjct: 452 APAEHMLLLNYEDRPGMIGKIGTIMGAHSINIASMNLGRREEKGEAMVILSLDSAVPLEV 511 Query: 394 LQAMKAIPGTIRARLLY 410 ++ ++ R ++ Sbjct: 512 MEEVRIATEATFIRAIH 528 >UniRef50_UPI0000DB72A4 PREDICTED: similar to 3-phosphoglycerate dehydrogenase n=2 Tax=Apocrita RepID=UPI0000DB72A4 Length = 478 Score = 412 bits (1060), Expect = e-113, Method: Composition-based stats. Identities = 109/377 (28%), Positives = 173/377 (45%), Gaps = 16/377 (4%) Query: 13 FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINA 72 L+ + V E L G +K L E+L + +++ + +RS T +T DV Sbjct: 8 VLISDPVDACCGELLVRHGIPVTTKYK--LSKEKLIKELQNHEGLIVRSETKVTADVFAC 65 Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA 132 L +G G + +DL+AA ++G+ V N P N+ S EL + L R V +A Sbjct: 66 CPNLRVVGRAGTGVDNIDLEAATRKGVIVLNTPGGNSISACELTCALISNLARNVTQAVQ 125 Query: 133 KAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNAT 192 G W++ FE GK L ++G G IG ++ ++ GM V +D N Sbjct: 126 SLKDGRWDRKLYSGFELSGKTLAVLGMGRIGREVTRRMQAYGMRVIAFDPLLTSEDANYL 185 Query: 193 QVQ--HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 V+ L ++ M+D +++H P P TKN++ A ++ K G +IN +RG +VD AL Sbjct: 186 NVEKFSLDEIWPMADYITVHTPLIPQTKNLINATTLAKCKKGVRIINVARGGIVDEEALL 245 Query: 251 DALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAG 310 +AL S H AGAA+DVF EP + L V+ TPH+G ST+EAQ+ + E+A Sbjct: 246 NALKSGHCAGAALDVFTEEPPK--NSVILELIAHPKVISTPHLGASTEEAQQRVAEEIAQ 303 Query: 311 KLIKYSDNGSTLSA----VNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIA 366 + + ST VN P +S + + VL + + G+N+ Sbjct: 304 QFL-VLAGRSTEYVITGIVNAPMLSAAISDENASWIELSKKLAVLVGILSGQTKNGLNLI 362 Query: 367 A-----QYLQTSAQMGY 378 Q + + Y Sbjct: 363 NAPTLAQEIGIDIKRSY 379 >UniRef50_C9LMC8 Phosphoglycerate dehydrogenase n=1 Tax=Dialister invisus DSM 15470 RepID=C9LMC8_9FIRM Length = 530 Score = 411 bits (1057), Expect = e-113, Method: Composition-based stats. Identities = 110/352 (31%), Positives = 172/352 (48%), Gaps = 11/352 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K + V ++A E L +I +D+++L + I + + RS+T +T++VI Sbjct: 2 FKIFITADVAKEAKEFLEKEFVVDIR---PNMDEDELCKVIGEYDAVITRSQTKITKNVI 58 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +AA L IG +G + +D+ A +GI V N P SNT + E + +L + R +P+A Sbjct: 59 HAATNLKVIGRAGVGIDGIDIPEATAKGITVVNTPESNTIAACEHTLALMLSITRYIPQA 118 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + G W++ + + K +GIIG G +G+ + ++ M YD L G Sbjct: 119 HQSIMEGRWDRKSFTGIQLLNKTVGIIGVGRVGSNVAKRLQAFNMKTIGYDPYIPLERGQ 178 Query: 191 --ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + L LL SD ++LH P TK M+GAKEI MK G ++NASRG V+DI A Sbjct: 179 QLGVDLVDLDTLLRESDYITLHTPLTEETKGMIGAKEIEKMKDGVRIVNASRGAVIDIDA 238 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +AL + +AGA IDV+ EP + +P NV LTPH+G ST EAQ + +V Sbjct: 239 LAEALKTGKVAGAGIDVWTNEPLKPEN---NPFLGMKNVTLTPHLGASTVEAQTGVATDV 295 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAE 360 A + +AVN S ++ + N + + A+ Sbjct: 296 ARGVADALHGEPVATAVNA---SPITRATLAVIQPYFNLCERMGNIGIDLAD 344 Score = 58.8 bits (142), Expect = 3e-07, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 34/71 (47%) Query: 340 LMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKA 399 ++ HEN+PG++ ++ I + GVNI + S ++ + D+D+ L + Sbjct: 456 ILAPHENKPGMIGQMSGILGKAGVNINGMQVGASKDKNTNIMAVAIDKDIPSAILPVLAN 515 Query: 400 IPGTIRARLLY 410 I G +++ Sbjct: 516 IDGIHGITVIH 526 >UniRef50_B5YAK7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Dictyoglomus thermophilum H-6-12 RepID=B5YAK7_DICT6 Length = 316 Score = 410 bits (1055), Expect = e-113, Method: Composition-based stats. Identities = 104/322 (32%), Positives = 157/322 (48%), Gaps = 15/322 (4%) Query: 11 IKFLLV----EGVHQKALESLRAAGYTN-IEFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 K L+ E + K E + G + L +E+++E IRD + + + Sbjct: 2 FKVLITPRSFEKIKDKFEEVFKEEGIEVMLNPFGRVLTEEEMRELIRDVDGLIV-GIDPV 60 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 T V+ A KL I + +G + +D+ A KR I V N P +N+ +VAEL +G ++ +LR Sbjct: 61 TSKVLKNANKLKVISKYGVGVDNIDILEAKKRNIVVTNTPGANSNAVAELTVGLIINVLR 120 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 + ++ K G W++ E K LG+IG G IG ++ L + + V +D Sbjct: 121 KINLSDKKTREGRWDR--FIGNELSEKTLGVIGTGSIGRRVIELLKGFNLRVLCFDKYPD 178 Query: 186 LPLG--NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 L +LL SDVVS+HVP T +M+ KE+ +MK ++LIN SRG + Sbjct: 179 YEWASKEKVFYVTLDELLRSSDVVSIHVPLTEETYHMISEKELRMMKKNAVLINTSRGGI 238 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 VD AL L ++GA +DVF EP P SPL + DNV++T HIG T+EA N Sbjct: 239 VDEDALYRFLKEGRISGAGLDVFEKEP-----PQNSPLLQLDNVVVTSHIGAHTEEAVAN 293 Query: 304 IGLEVAGKLIKYSDNGSTLSAV 325 + L+ LS V Sbjct: 294 MAKLAVENLLLALKGREPLSRV 315 >UniRef50_B7P3M8 D-3-phosphoglycerate dehydrogenase, putative (Fragment) n=2 Tax=Coelomata RepID=B7P3M8_IXOSC Length = 473 Score = 409 bits (1052), Expect = e-112, Method: Composition-based stats. Identities = 101/338 (29%), Positives = 156/338 (46%), Gaps = 9/338 (2%) Query: 6 LEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 + K L+ + V ++ L G K +L ++I + +RS T + Sbjct: 1 MALAIKKVLISDAVDASCVKILENNGVQVT--LKTDFTKPELLQAIEGYDALIVRSATKV 58 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 T DVI A + L IG G + +D DAA ++GI V NAP NT S AEL ++ L R Sbjct: 59 TSDVIKAGQALKVIGRAGTGVDNIDCDAATRQGILVINAPGGNTLSAAELTCAMIVTLSR 118 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 +P A G W++ E GK L I+G G IG ++ + +S GM +D Sbjct: 119 EIPAATMSLKAGKWDRKTFMGNELYGKTLAIVGLGRIGKEVALRMQSFGMKTIGFDPIVP 178 Query: 186 LP--LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 + L ++ ++D +++H P P TK+++G + K G +IN +RG + Sbjct: 179 KEVSREFGVESMSLDEIWPLADYITVHTPLIPQTKDLIGKASLQKCKKGVKIINVARGGI 238 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 V+ L AL S H GA +DVF EP N+ L V+ TPH+G +T+EAQ Sbjct: 239 VNEDDLLAALESGHCGGAGLDVFLEEPPKNTQ-----LIAHPKVVCTPHLGANTKEAQLR 293 Query: 304 IGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLM 341 + E+A + + S S VN P +S + Sbjct: 294 VAQEIAEQFVDLSQGKSVPGVVNAPSLSQTQVPENKPW 331 >UniRef50_C2BW43 Phosphoglycerate dehydrogenase n=1 Tax=Mobiluncus curtisii ATCC 43063 RepID=C2BW43_9ACTO Length = 413 Score = 409 bits (1052), Expect = e-112, Method: Composition-based stats. Identities = 181/400 (45%), Positives = 250/400 (62%), Gaps = 5/400 (1%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K LL+E H+ A + A ++ G+LD+ L ++++ +G+RS+T+L++ V + Sbjct: 3 KILLLENPHEVANKVFSDAN-VQVDRIDGSLDENDLIKALQGYQMVGIRSKTNLSKRVFD 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 LV G F IGTNQ+DL AAK G+ VFNAP+SNTRSVAEL I E++ L R +P N Sbjct: 62 ECPDLVCAGTFTIGTNQIDLKEAAKHGVAVFNAPYSNTRSVAELAIAEIIALARQLPVRN 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 A W K A GS E RGK LGIIGY GTQL ILAE++GM V FYD+ KLP+GNA Sbjct: 122 AHLQNADWQKTAKGSHEVRGKTLGIIGYSSTGTQLSILAEAMGMKVQFYDLAKKLPIGNA 181 Query: 192 TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCD 251 Q L + L +D VSLHV S +NM +++ MKPG+ L+N SRG VV++ L + Sbjct: 182 KQCNSLEEALQGADFVSLHVDGRASNENMFTKVQMNQMKPGAKLLNLSRGFVVNLDDLAE 241 Query: 252 ALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGK 311 AL S + G AIDVFP EP N + F SP+ +N +LTPHIGGST EAQE+IG VAGK Sbjct: 242 ALDSGQIGGCAIDVFPDEPRKNGEEFHSPIMGKENTILTPHIGGSTLEAQEDIGWFVAGK 301 Query: 312 LIKYSDNGSTLSAVNFPEVSLPL--HGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQY 369 + Y +G T+ +VN P +SL + R+ IH+N PGV+ +N++F++ GVNI Q Sbjct: 302 ICTYLQSGETVMSVNMPNLSLEPTDNTKYRITLIHKNVPGVMAKINQLFSDAGVNIEGQV 361 Query: 370 LQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 L T+ ++GYV+ DI ++ + AL + T+ R + Sbjct: 362 LGTNGEVGYVIGDIS--SEMPKAALDEIAKFDSTLSVRCI 399 >UniRef50_D2RMS7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RMS7_ACIFE Length = 529 Score = 408 bits (1051), Expect = e-112, Method: Composition-based stats. Identities = 111/393 (28%), Positives = 178/393 (45%), Gaps = 13/393 (3%) Query: 8 KDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 DK K ++VE + K +E L+A + K + E+L + + D I +RS T + E Sbjct: 1 MDKKKVIVVERISDKGVEMLKAQPDLEVTV-KFDIPREELLKIVGDYDAIIVRSVTKVNE 59 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 + AA L +G G + +D++ A KRGI V N P +N S AE IG +L R Sbjct: 60 EFYQAARNLKVVGRAGNGVDNIDIEGATKRGIIVVNTPEANVISAAEHTIGLMLASCRNT 119 Query: 128 PEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL- 186 +A VW++ E K LGIIG G IGT + ++ M V YD Sbjct: 120 VKAQKMIESRVWDRKNLKGVELYHKTLGIIGLGRIGTLVTKRMQAFEMKVIAYDPYIPDS 179 Query: 187 --PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + + L DLL +DV+++H P+ T NM+G +E+ K G L+N +RG + Sbjct: 180 RFKRLGVEKCETLDDLLAKADVITIHTPKTEETINMIGKEELKKCKKGVRLVNCARGGLY 239 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 + A+ DA+ +A +DV EP SPL + +LTPH+G T EAQ+ + Sbjct: 240 NEQAVADAIKEGQVASIGLDVLVDEPKP-----ISPLIGLEQCVLTPHLGADTVEAQDKV 294 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIF-AEQGV 363 G+ +A +++ + +AVN P + G M + L L + Sbjct: 295 GISIAQEVVNVLNGQMVPNAVNLPALHPQELEG---MMGYLQLGECLGKLYYQMEKDPVD 351 Query: 364 NIAAQYLQTSAQMGYVVIDIEADEDVAEKALQA 396 + Y +A + +I + + + L+ Sbjct: 352 KVEVVYEGPAANLETTLITRSILKGLFDPILKE 384 Score = 46.5 bits (110), Expect = 0.002, Method: Composition-based stats. Identities = 12/70 (17%), Positives = 31/70 (44%) Query: 334 LHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKA 393 + ++ ++++PG++ + + VNIA + + G ++ + D V + Sbjct: 452 VPEHYMILAKNDDKPGMIGQMGTLLGAAHVNIANMQVARKPKTGNAMMIMTVDSPVEKAT 511 Query: 394 LQAMKAIPGT 403 LQ + + G Sbjct: 512 LQMIAGLDGI 521 >UniRef50_C8WI96 D-3-phosphoglycerate dehydrogenase n=1 Tax=Eggerthella lenta DSM 2243 RepID=C8WI96_EGGLE Length = 526 Score = 408 bits (1050), Expect = e-112, Method: Composition-based stats. Identities = 118/383 (30%), Positives = 177/383 (46%), Gaps = 17/383 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K L+ E + + L LR G K + E+L E++ + +RS T +T +V+ Sbjct: 3 KKVLVTERLAEAGLAVLRDKGCEV--DVKLKMTPEELIETVPGYDALIVRSATKVTAEVV 60 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA++L IG +G + VD++AA + GI V NAP SN S AE IG +L R VP+A Sbjct: 61 EAADRLRIIGRAGVGVDNVDVEAATEHGIIVCNAPTSNIVSAAEHAIGLMLACARKVPQA 120 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 NA H GVW + E K L I G G IG + A + GM + YD Sbjct: 121 NASMHEGVWERGKYTGVELYEKTLAIFGLGRIGGLVAERARAFGMKLIGYDPYCSPERAE 180 Query: 191 ATQVQ---HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 V + L+ ++D +++H+P+ T M G + + MK G +L+NA+RG + D Sbjct: 181 QLGVTLYDDVDALVPLADFITVHLPKTKETIGMFGPDQYARMKDGVILVNAARGGIFDEK 240 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 +L D LA+ + IDV +EP T SPL EFDN +LTPHI STQEAQ G++ Sbjct: 241 SLADFLAAGKIGAVGIDVHESEPCT-----DSPLREFDNAILTPHIAASTQEAQLRAGVQ 295 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPG-VLTALNKIFAEQGVNIA 366 A + + +A+N V + G +L ++ Sbjct: 296 TAEYVAAGLEGSIVPTALNMAPVPPEVMDAVGPYVPACQMMGSMLAQIDGEIP------Q 349 Query: 367 AQYLQTSAQMGYVVIDIEADEDV 389 L T+ + + I + Sbjct: 350 FLKLTTAGALAHADASILVAGTL 372 >UniRef50_B0K2Z0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=3 Tax=Thermoanaerobacter RepID=B0K2Z0_THEPX Length = 324 Score = 407 bits (1048), Expect = e-112, Method: Composition-based stats. Identities = 103/327 (31%), Positives = 155/327 (47%), Gaps = 11/327 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K LL E +H + + L + L ++D I LR+R+ +T +VI Sbjct: 2 KKVLLSEEIHPEGRKLLEGKFEIVT---APDTSQQTLISMVKDVDAIILRTRSKITREVI 58 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A L I G + +D++AA ++GI V N P N SVAE I +L L + + Sbjct: 59 ENAPHLKIISRTGAGVDNIDVNAATEKGILVCNLPAVNNLSVAEHTIAMILNLSKQLSLM 118 Query: 131 NAKAHRGVW-NKLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIENKLPL 188 + G W + + S E GK LGI+G G+IG+ + LGM + YD K Sbjct: 119 DKAVRSGNWGARNSNISVEIEGKVLGIVGMGNIGSLVAKKCHDGLGMKIVAYDPYVKEKF 178 Query: 189 GNATQ--VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 V +L SD V+LH P+ P T+ M+ + I MK + LINA+RGTV+D Sbjct: 179 RGYDYKFVDTREELFKESDFVTLHCPDIPETRGMITRELIYSMKHTAYLINAARGTVIDE 238 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL +AL K +AGA +DVF EP ++ + L +NV+L+PH T+EA + + Sbjct: 239 QALIEALKEKRIAGAGLDVFQQEPPSSDN----ELLRLENVILSPHSAALTKEATVRMAV 294 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEVSLP 333 E +I Y + N+ + Sbjct: 295 EAVQAVIDYFEGRQPKYIYNYKALKEK 321 >UniRef50_B6H0R3 Pc12g10550 protein n=23 Tax=Fungi/Metazoa group RepID=B6H0R3_PENCW Length = 596 Score = 407 bits (1048), Expect = e-112, Method: Composition-based stats. Identities = 109/349 (31%), Positives = 172/349 (49%), Gaps = 7/349 (2%) Query: 6 LEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 L + K L+ E + L LR++ + L ++L + I D + +RS T + Sbjct: 4 LRASRPKVLVPEKLSPDGLALLRSSLDV---HERKGLSADELLQIIPDYDALLVRSETKV 60 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 T V+ AA+ L + +G + VD++ A K GI V N+P N + AE I ++ + R Sbjct: 61 TATVLRAAKNLKVVARAGVGVDNVDVEEATKLGIVVVNSPSGNIGAAAEHTIALMMSMAR 120 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE-- 183 +PE+ A G W + E +GK L IIG G +G + LA+ LGM V D Sbjct: 121 KIPESCASLKDGKWERSKFVGVEVKGKTLSIIGLGKVGLTVARLAKGLGMNVNALDPYAS 180 Query: 184 -NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 + V L +LL +D +++H P ST+ M+ E++ +KPG+ ++N +RG Sbjct: 181 PAVAASASVALVSSLPELLASADFLTIHTPLIASTRGMIAEAELAQLKPGARVLNVARGG 240 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 D AL AL S HL+GAAIDVF +EP + L ++TPH+G ST EAQE Sbjct: 241 TFDEDALLAALESGHLSGAAIDVFTSEPPAPDS-SAARLIAHPRAVVTPHLGASTVEAQE 299 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVL 351 N+ ++V ++++ SAVN P + + + + G L Sbjct: 300 NVSVDVCEQVLEILQGSLPRSAVNAPLILPEEYKKLQPFVRLVEKLGSL 348 >UniRef50_Q0B0Y6 D-3-phosphoglycerate dehydrogenase n=9 Tax=Bacteria RepID=Q0B0Y6_SYNWW Length = 530 Score = 407 bits (1046), Expect = e-112, Method: Composition-based stats. Identities = 99/379 (26%), Positives = 176/379 (46%), Gaps = 16/379 (4%) Query: 8 KDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 ++ K ++ E + + +E L+ + ++ + E+L E I + +RS T + E Sbjct: 1 MERKKVIVSERIADEGIELLKTELEVD---YRDGISREELLEIIDQYDALIVRSVTQVDE 57 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 ++I A++L +G G + +D+D + G+ V N P SNT S AE I LL +R Sbjct: 58 ELIRRAKRLKIVGRAGNGIDNIDVDVCTRYGVIVANTPDSNTISAAEQTISLLLSSIRNT 117 Query: 128 PEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP 187 A+ G W++ E GK +GI+G G IG+ + ++ M V YD Sbjct: 118 AWASEYLKGGTWDRKPFRGVELYGKTVGIVGLGRIGSMVATRLKAFNMRVIAYDPYISDE 177 Query: 188 ---LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 A +++ L +L+ +D +++H P N T +M+ + + L K G ++N +RG ++ Sbjct: 178 RFTRFGAEKMESLEELVKEADFITVHTPRNEETMHMIDERILGLAKEGVRVVNCARGGII 237 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 AL L SK + A +DVF EPA +PL +F +V++TPH+G T EAQ+ + Sbjct: 238 KEEALLKGLESKKVLSAGLDVFEKEPA-----IDNPLFQFKSVVVTPHLGADTFEAQKRV 292 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVN 364 G +A ++IK + VN P + + + L + + Sbjct: 293 GENIAEQVIKALKGEIVPNLVNLPAMLKDELEYLKPYITLAEK---LGNIYYQMEKSA-- 347 Query: 365 IAAQYLQTSAQMGYVVIDI 383 ++ L S + +I Sbjct: 348 VSRVELTYSGPISSNETEI 366 Score = 45.0 bits (106), Expect = 0.006, Method: Composition-based stats. Identities = 16/69 (23%), Positives = 31/69 (44%) Query: 336 GGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQ 395 G L+ +E+RP V+ ++G+NIA + + ++ I D V E L+ Sbjct: 454 EGYLLVVENEDRPRVIGPFATALGDEGINIAGMKVARKTKGEKAIMIINVDNKVEEPVLE 513 Query: 396 AMKAIPGTI 404 + + G + Sbjct: 514 KLSQLDGIV 522 >UniRef50_B4AUS0 Glyoxylate reductase n=1 Tax=Cyanothece sp. PCC 7822 RepID=B4AUS0_9CHRO Length = 326 Score = 406 bits (1044), Expect = e-112, Method: Composition-based stats. Identities = 86/326 (26%), Positives = 140/326 (42%), Gaps = 11/326 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K + + ++ L L + I + E L E ++ + + E +I Sbjct: 4 PKIFVTRQLPERGLNPLLSHAEIEIWPERQPPAYEILLEKVQQIDGLLCLLTDRIDEQLI 63 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 N + L I +G + +D+ AA R IPV N P T + A+L L+ R + E+ Sbjct: 64 NTGKSLKVISQMAVGYDNIDIKAATNRKIPVGNTPGVLTDATADLTWALLMCAARRIIES 123 Query: 131 NAKAHRGVWNKLAAG---SFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL- 186 G W + G LGI+G G IG + A + V + + Sbjct: 124 EQYVRAGSWQTWEPTLLLGTDLSGATLGIVGLGRIGEAVARRASGFNLRVIYSSRHRRSK 183 Query: 187 --PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + + LL SD+++LH + T +++ + +LMK ++LIN +RG +V Sbjct: 184 EIEAALGVEYVEFNRLLQESDIITLHTALSKETHHLISYAQFALMKRSAILINTARGAIV 243 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL L S +AGAA+DV EP P SPL N+++TPHIG ++ + + + Sbjct: 244 DPQALYQTLKSGQIAGAALDVTEPEPI----PLDSPLLSLKNLIITPHIGSASYQTRLKM 299 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEV 330 A L+ N VN PE+ Sbjct: 300 ATMAANNLLAGLLNQPLPYCVN-PEI 324 >UniRef50_Q7UQL2 Phosphoglycerate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UQL2_RHOBA Length = 540 Score = 406 bits (1044), Expect = e-111, Method: Composition-based stats. Identities = 104/370 (28%), Positives = 169/370 (45%), Gaps = 14/370 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + L+++ + Q+ ++ L A+ + L E+L++S+ + LRS +T + + Sbjct: 2 HRILVLDDIAQEGIDLLEAS-EGIEYEVRTKLKGEELRQSLNEFDAAILRSGVTITPESL 60 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +L A+ +GT+ +D AA +RGI V N P NT S AE LL + R + A Sbjct: 61 EGNTRLRALVRAGVGTDNIDKPAATRRGIVVMNTPAGNTVSTAEHTFAMLLAMSRNIAAA 120 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 N G W++ + GK LGI+G G IG ++ A++ M V +D Sbjct: 121 NQSLVEGRWDRKKFMGTQVAGKTLGIVGMGRIGREVASRAQAFDMDVVAFDPFLTDDQAE 180 Query: 191 ---ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 +V + D+L D +++H P P T+ ++G +++ +KPG +IN +RG + D Sbjct: 181 SLKVRRVATVDDMLPQIDYLTVHTPLTPETRGLIGMEQLEKVKPGLRIINVARGGIYDSE 240 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 A+ + L S L G A+DV+ EP T SPL V+ TPH+G ST+EAQ + +E Sbjct: 241 AMVEGLKSGKLGGVALDVYENEPCT-----DSPLFGMPGVVCTPHLGASTEEAQTQVAVE 295 Query: 308 VAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAA 367 L+ Y G +VN + R H N L G I Sbjct: 296 GIHLLLNYLRTGEIRHSVNVASLDPKTLAELR---GHLNVAHRLGLFLSQL--HGGGIDH 350 Query: 368 QYLQTSAQMG 377 L ++ Sbjct: 351 ARLTFRGEVS 360 Score = 44.2 bits (104), Expect = 0.008, Method: Composition-based stats. Identities = 18/80 (22%), Positives = 34/80 (42%), Gaps = 2/80 (2%) Query: 332 LPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQM--GYVVIDIEADEDV 389 G+ L+ +H++ PG++ + F GVNIA + G + + D +V Sbjct: 448 ESFLDGKLLVFVHKDVPGIIGRVGTTFGSHGVNIAQMAVGREGDAPGGAAIGVLSLDGEV 507 Query: 390 AEKALQAMKAIPGTIRARLL 409 AL + AI +++ Sbjct: 508 PTAALDDLLAIDAITECQVI 527 >UniRef50_Q2RH37 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=6 Tax=Bacteria RepID=Q2RH37_MOOTA Length = 329 Score = 405 bits (1042), Expect = e-111, Method: Composition-based stats. Identities = 108/335 (32%), Positives = 144/335 (42%), Gaps = 11/335 (3%) Query: 8 KDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 K + V Q AL+ L I L +L E +R I L + Sbjct: 1 MSKWNVYVTRLVPQPALDLLAEYCDLEINPEDRVLTRAELLEKVRGRDGILCLLTDILDD 60 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 +V AA+ +G N VDL+AA + GI + N P T + A++ L + R V Sbjct: 61 EVFTAAKGAKIFANLAVGFNNVDLEAATRHGIMITNTPGVLTEATADMAWALLFAVARRV 120 Query: 128 PEANAKAHRGV---WNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--I 182 E + G W L E GK LG+IG G IGT A M V ++D Sbjct: 121 VEGDKFTRAGKYKGWGPLLMLGQEITGKTLGVIGAGRIGTAFARKARGFDMKVLYHDVQP 180 Query: 183 ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 Q LL +D VSLHVP PST +++ E+ LMK ++LIN SRG Sbjct: 181 SKAFEEATGGQFVDKETLLKEADFVSLHVPLMPSTTHLISTPELKLMKKTAILINTSRGP 240 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 VVD AL AL K + GA +DVF EP L + +NV+L PHI +T E + Sbjct: 241 VVDEKALVKALREKEIWGAGLDVFENEPELAPG-----LADLENVVLCPHIASATWETRT 295 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGG 337 N+ L A L+ +N PEV HG Sbjct: 296 NMALMAANNLLAALRGELPPQCLN-PEVYYRQHGK 329 >UniRef50_D0MG73 Glyoxylate reductase n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MG73_RHOM4 Length = 322 Score = 405 bits (1041), Expect = e-111, Method: Composition-based stats. Identities = 92/318 (28%), Positives = 146/318 (45%), Gaps = 14/318 (4%) Query: 12 KFLLVEGVHQKALESLRAAGYTNI---EFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 + ++ V ++ L L G+ + LD++ L E+ R+A + +T Sbjct: 3 RIVVTRPVMEEGLRPLFENGHQVEILDPDPEHPLDEDALIEAAREADALITMPSDPVTAR 62 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 V+ KL + +G +DL+AA RGI V + P T + A+ LL L+R V Sbjct: 63 VLENCPKLRIVAQHAVGYENIDLEAARARGIVVTHTPGVLTDATADFTFALLLALVRRVR 122 Query: 129 EANAKAHRG---VWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 EA+ G W + R K LGI+G G IG+ + A GM V +Y+ Sbjct: 123 EADRYVREGHFKRWETKLLLGHDLRDKVLGIVGLGRIGSAVARRALGFGMRVVYYNRRPA 182 Query: 186 LPLGNA---TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 P + +LL SDV+S+H P N + ++ + MKP ++L+N +RG Sbjct: 183 NPTIERQSCARYVSFDELLRTSDVISIHCPLNKESYHLFDRAAFAKMKPTAVLVNTARGP 242 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 +VD AL +AL +AGAA+DVF EP + L D V+L PH+G +T EA+ Sbjct: 243 IVDEEALVEALEQGQIAGAALDVFEHEPRVHP-----ALLRSDRVVLAPHLGSATVEART 297 Query: 303 NIGLEVAGKLIKYSDNGS 320 + A ++ + Sbjct: 298 AMARACAEAVLAVLNGEE 315 >UniRef50_D2R855 D-3-phosphoglycerate dehydrogenase n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2R855_9PLAN Length = 542 Score = 404 bits (1040), Expect = e-111, Method: Composition-based stats. Identities = 109/348 (31%), Positives = 168/348 (48%), Gaps = 9/348 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+++ + Q+ L+ L AA E G L E+LK+S+ + RS +T + + Sbjct: 3 RILILDPIAQEGLDMLAAAPGIEYEVRTG-LKGEELKKSLAEFDGAICRSGVTITAESLE 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 ++ AI +GT+ +D +AA + GI V N P NT S AE +L L R V EA Sbjct: 62 GNRRMRAIARAGVGTDNIDKNAATRLGIVVMNTPTGNTLSTAEHTFTLMLALSRRVAEAY 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG-- 189 K G W++ + K LGI+G G IG ++ A + M V +D Sbjct: 122 HKLIGGKWDRKTFMGTQLADKTLGIVGLGRIGQEVAKRAIAFQMKVLGFDPFLSTEQAAK 181 Query: 190 -NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 +V+ + ++L D +++H P P T N++G E+ ++KPG LIN +RG + + A Sbjct: 182 LGIERVETVQEMLPRVDYLTVHTPLTPETTNLVGFPELEVLKPGVRLINCARGGIYNEDA 241 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L + L + + G A+DVF TEP P+ NVL TPH+G ST+EAQ+ + +E Sbjct: 242 LVEGLKTGKIGGVALDVFVTEPCDK-----HPIYGMPNVLCTPHLGASTEEAQQQVAIEA 296 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNK 356 LI + G AVN V + R GVL A + Sbjct: 297 VQLLINFFTTGEVRHAVNMASVDPKTLASIKGYLDLAYRLGVLLAQCQ 344 Score = 42.3 bits (99), Expect = 0.031, Method: Composition-based stats. Identities = 24/133 (18%), Positives = 49/133 (36%), Gaps = 25/133 (18%) Query: 297 TQEAQENIGL----EVAG-------KLIKYSDNGSTLSAVNFPEVS-------LPLHGGR 338 TQE++ ++G A ++ + G+ N P + G Sbjct: 401 TQESRSDMGAFSSSMTAEVHGSSGSQVAAATLFGN-----NMPRLIRLGDYRLEAYLDGN 455 Query: 339 RLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQM--GYVVIDIEADEDVAEKALQA 396 L+ H + PG++ A+ IF VNI + + + G V + D + A+ Sbjct: 456 LLIFTHHDVPGIIGAVGTIFGNHKVNIGQMSVGRAGIIPGGGAVGVLNLDNVPPQAAIDE 515 Query: 397 MKAIPGTIRARLL 409 ++ P +++ Sbjct: 516 VQQHPDIQSVKII 528 >UniRef50_A1HQU2 Glyoxylate reductase n=1 Tax=Thermosinus carboxydivorans Nor1 RepID=A1HQU2_9FIRM Length = 324 Score = 403 bits (1038), Expect = e-111, Method: Composition-based stats. Identities = 91/322 (28%), Positives = 146/322 (45%), Gaps = 7/322 (2%) Query: 8 KDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 K + ++ + AL + + + + L E + DA + + + Sbjct: 1 MKKYQVVVAGKMRPCALAKISSECHVRQWDKIEPIPRNLLYEWLADAEGLVSTGDVRVDD 60 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 +++ A +L I +G + VD+ A +RGIP N P + A+L G LL R + Sbjct: 61 ELLAHAPRLRVIAQASVGYDNVDIAACTRRGIPFGNTPGVLVEATADLTFGLLLCAARRI 120 Query: 128 PEANAKAHRGVW--NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 E + G W N + GK LGI+G G IG + A++ GM V +++ + Sbjct: 121 HEGWNQVASGRWLNNHDVPFGIDLYGKTLGIVGMGRIGAAVARRAKACGMKVIYHNRSRR 180 Query: 186 LPLGN-ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + DLL +D + + VP +P+++ M G E + MK + INA+RG +V Sbjct: 181 TDDEHLGATYVAFDDLLAQADCIVVLVPLSPASQGMFGRAEFAKMKRTAYFINAARGGLV 240 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL DAL +A AA+DV EP P PL NVL+TPHIG +T E ++ + Sbjct: 241 DTQALYDALKEGQIAYAALDVTDPEPL----PGDHPLLTLPNVLITPHIGSATHETRDRM 296 Query: 305 GLEVAGKLIKYSDNGSTLSAVN 326 + A L+ + VN Sbjct: 297 AMLTADNLLAGLARRPLPACVN 318 >UniRef50_Q5SZU1 Phosphoglycerate dehydrogenase n=11 Tax=Eutheria RepID=Q5SZU1_HUMAN Length = 499 Score = 402 bits (1034), Expect = e-110, Method: Composition-based stats. Identities = 107/349 (30%), Positives = 160/349 (45%), Gaps = 9/349 (2%) Query: 50 SIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNT 109 ++D + +RS T +T DVINAAEKL +G G + VDL+AA ++GI V N P N+ Sbjct: 10 LLQDCEGLIVRSATKVTADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNS 69 Query: 110 RSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGIL 169 S AEL G ++ L R +P+A A G W + E GK LGI+G G IG ++ Sbjct: 70 LSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATR 129 Query: 170 AESLGMYVYFYDI--ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEIS 227 +S GM YD ++ Q L ++ + D +++H P PST ++ + Sbjct: 130 MQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFA 189 Query: 228 LMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNV 287 K G ++N +RG +VD AL AL S AGAA+DVF EP P L + +NV Sbjct: 190 QCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEP-----PRDRALVDHENV 244 Query: 288 LLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENR 347 + PH+G ST+EAQ G E+A + + S VN ++ + Sbjct: 245 ISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEA 304 Query: 348 PGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQA 396 G L I TS + + + ++A + Sbjct: 305 LGTLMR--AWAGSPKGTIQVITQGTSLKNAGNCLSPAVIVGLLKEASKQ 351 >UniRef50_Q5HNI1 D-3-phosphoglycerate dehydrogenase n=73 Tax=Staphylococcus RepID=Q5HNI1_STAEQ Length = 531 Score = 402 bits (1033), Expect = e-110, Method: Composition-based stats. Identities = 110/387 (28%), Positives = 185/387 (47%), Gaps = 11/387 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K L+ + + + L+S+ +++ L + L I + +RS+T +TE +I Sbjct: 3 HKILVSDPISEDGLQSILKHPEFDVDIQTD-LSENDLVNMISTYDALIVRSQTQVTERII 61 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 NAA L I +G + ++++AA +GI V NAP NT S E + LL + R +P+A Sbjct: 62 NAATNLKVIARAGVGVDNINIEAATLKGILVINAPDGNTISATEHSVAMLLAMARNIPQA 121 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + WN+ A E GK LG+IG G IG + A+S GM + +D Sbjct: 122 HQSLRNKEWNRKAFRGVELYGKTLGVIGAGRIGLGVAKRAQSFGMKILAFDPYLTEDKAK 181 Query: 191 --ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 Q+ + ++ SD V++H P P T+ ++G+ + K +IN +RG ++D A Sbjct: 182 SLDIQIATVDEIAEKSDFVTVHTPLTPKTRGIVGSSFFNKAKQNLQIINVARGGIIDETA 241 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +AL + + AAIDVF EP P SPL + D +++TPH+G ST EAQE + + V Sbjct: 242 LIEALDNNLIDRAAIDVFEHEP-----PTDSPLIQHDKIIVTPHLGASTVEAQEKVAVSV 296 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTAL-NKIFAEQGVNIAA 367 + ++I+ G+ AVN P++ L + + ++ I Sbjct: 297 SEEIIEILTKGNVEHAVNAPKMDLSKVD--KTTQSFIGLSTTIGEFAIQLLDGAPSEIKV 354 Query: 368 QYLQTSAQMGYVVIDIEADEDVAEKAL 394 +Y AQ +I ++ ++ L Sbjct: 355 KYAGDLAQNDTSLITRTIITNILKEDL 381 Score = 48.1 bits (114), Expect = 7e-04, Method: Composition-based stats. Identities = 15/77 (19%), Positives = 36/77 (46%), Gaps = 3/77 (3%) Query: 335 HGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKAL 394 +L+ H+++PG++ + G+NIA+ L + G ++ + D+ +E+ + Sbjct: 453 PNQYQLVTCHKDKPGIVGQTGNLLGSHGINIASMTLGRNDAGGDALMILSIDQQASEEVI 512 Query: 395 QAMKAIPG---TIRARL 408 + + G I +L Sbjct: 513 KILNETSGFNKIISTKL 529 >UniRef50_B0TB58 Glyoxylate reductase n=7 Tax=cellular organisms RepID=B0TB58_HELMI Length = 328 Score = 400 bits (1029), Expect = e-110, Method: Composition-based stats. Identities = 97/322 (30%), Positives = 155/322 (48%), Gaps = 9/322 (2%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 + K L+ + Q AL+ ++ ++ + +L+ + DA + + +DV Sbjct: 6 RPKVLVTREIPQPALDRIKEFARLDLWPAFPPPEKGELQRMLADADALLCMITDPIDDDV 65 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I A +KL I + +G + +D+ AA +R I V N P + T + A+L LL R + Sbjct: 66 IEAGKKLRVIANYGVGYDNIDIAAATRRRIAVTNTPDALTEATADLAFALLLATARNLIA 125 Query: 130 ANAKAHRG---VWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--N 184 A+ G W+ + G LGI+G G IG + A M+V + Sbjct: 126 ADRFTRDGFWIAWHPQLLLGRDVFGSTLGIVGLGRIGEAVARRARGFNMHVLYTARRRNP 185 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 K + L +LL SD VSLH P T++++GAKE+++MKP ++LIN +RG VV Sbjct: 186 KAEAELGIEYCTLEELLRRSDFVSLHTPLTLETRHLIGAKELNMMKPTAILINTARGGVV 245 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL +AL + GA +DVF EP + L E NV+++PHIG +T EA+ + Sbjct: 246 DQEALTEALQQGVIGGAGLDVFAEEPVAPEE----ALLELPNVVVSPHIGSATVEARTRM 301 Query: 305 GLEVAGKLIKYSDNGSTLSAVN 326 GL + + + VN Sbjct: 302 GLMAVENIQAVLEGRRPPNLVN 323 >UniRef50_C0WBM0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acidaminococcus sp. D21 RepID=C0WBM0_9FIRM Length = 529 Score = 399 bits (1027), Expect = e-110, Method: Composition-based stats. Identities = 113/393 (28%), Positives = 175/393 (44%), Gaps = 13/393 (3%) Query: 8 KDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 +K K L+ E + K + L+A ++ + E L + I + + +RS T + E Sbjct: 1 MEKQKVLVAERISDKGVVCLKAEKALDVTV-DFDIKREDLLQVIGNYDALIVRSVTKVNE 59 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 ++ +AA+KL IG G + +DLD A KRGI V N P +N S AE IG LL R Sbjct: 60 ELYDAAKKLKVIGRAGNGVDNIDLDGATKRGIIVVNTPEANIISAAEHTIGLLLASCRNT 119 Query: 128 PEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL- 186 AN G+W + E K LGIIG G IG + + M V YD Sbjct: 120 VRANKMLEEGIWERKDLKGSELYHKTLGIIGLGRIGALVTKRMHAFDMRVIAYDPYIPDS 179 Query: 187 --PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + + L DLL +DV+++H P+ T NM+GA E K G ++N +RG + Sbjct: 180 RFQRLGVEKCETLDDLLKEADVITIHTPKTEETVNMLGAAEWKKCKKGVRVVNCARGGLY 239 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 + L +A+ +A +DV EP SPL ++TPH+G ST EAQ+ + Sbjct: 240 NEQDLAEAVKEGIVASVGLDVVVDEP-----NPISPLIGMPQCVVTPHLGASTFEAQDKV 294 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVN 364 GL +A ++I +AVN P ++ R + L L + V+ Sbjct: 295 GLAIAEEVINVLGGKMVPNAVNLPAIAATELEDLRGYLALGDA---LGKLYYQLKKAPVD 351 Query: 365 -IAAQYLQTSAQMGYVVIDIEADEDVAEKALQA 396 + Y +AQ ++ + + L+ Sbjct: 352 RLEIVYEGAAAQQETQMVTRSILQGLLSPVLRE 384 Score = 45.7 bits (108), Expect = 0.003, Method: Composition-based stats. Identities = 13/85 (15%), Positives = 34/85 (40%), Gaps = 7/85 (8%) Query: 326 NFPEVSL-------PLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGY 378 N P ++ + + ++++PG++ + + VNIA + + G Sbjct: 437 NQPHITEVEGYQFDTIPAPYMIFARNDDKPGMIGQIGTLLGAGHVNIATMQVSRKKKEGT 496 Query: 379 VVIDIEADEDVAEKALQAMKAIPGT 403 ++ + D V L+ ++ + G Sbjct: 497 AMMVLTVDSAVDGATLEIVRNLDGI 521 >UniRef50_Q3AQU0 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chlorobiaceae RepID=Q3AQU0_CHLCH Length = 538 Score = 399 bits (1026), Expect = e-109, Method: Composition-based stats. Identities = 116/372 (31%), Positives = 186/372 (50%), Gaps = 15/372 (4%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ + VH + L G+ E K +L ++L I D + + +RS T L +V+ Sbjct: 13 MKVLITDSVHPQCGRLLLQHGFEVTE--KPSLSPKELHAIIADYNILIVRSATSLPAEVL 70 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A +L IG G + +DL+AA ++GI V + P N S AE LL R +P+A Sbjct: 71 AKATQLELIGRAGTGVDNIDLEAATRQGIVVMSTPGGNAVSAAEHTCAMLLAAARHIPQA 130 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 A +G WNK E GK L +IG G +G ++ + ++ GM YD Sbjct: 131 MADLKQGNWNKHLYAGIELEGKTLSLIGLGRVGREVAMRMQAFGMRTIAYDPAIADEDAA 190 Query: 191 --ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 ++ L + L +DV+++H + ST N++G + +SL KPG +++N +RG +++ A Sbjct: 191 LLDIELLPLHENLLRADVITIHSALDESTYNLLGKETLSLTKPGVIIVNCARGGIINEVA 250 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +ALAS H+A AA+DVF EP T PL +F V+ TPHI ST E QE + +++ Sbjct: 251 LAEALASGHVAAAALDVFTKEPIA----ATHPLLQFPQVIATPHISASTAEGQEKVAIQM 306 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPL-HGGRRLMHIHENRPGVLTALNKIFAEQGVNIAA 367 A ++I + +G A+N V L G +H+ E L + + Sbjct: 307 AEQIIAWKRDGILEGAINGTIVELAQLPGAHAYLHLAEKLGATLAQCTPLDGKH------ 360 Query: 368 QYLQTSAQMGYV 379 ++TS + Y Sbjct: 361 ITMKTSGEFLYT 372 >UniRef50_D1U9G1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Desulfovibrio RepID=D1U9G1_9DELT Length = 343 Score = 397 bits (1021), Expect = e-109, Method: Composition-based stats. Identities = 83/339 (24%), Positives = 136/339 (40%), Gaps = 12/339 (3%) Query: 8 KDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 K K + + ++ L + L +L S+ D + + Sbjct: 1 MSKPKIFITRRIPDAGIDMLAEVAEVVVNPEDRTLSRAELLASVADCQGVIGLLTEKIDA 60 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 + +AA KL + +G + +D+ A +R IPV N P T + AE + R V Sbjct: 61 EFFDAAPKLKGYANYAVGYDNIDVAEATRRSIPVSNTPGVLTDATAECAWALIFATARRV 120 Query: 128 PEANAKAHRGVWNKL---AAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--- 181 EA+ G W RGK LGI+G G IGT + +++ M V + Sbjct: 121 AEADRVMRSGAWQGWGPLQFIGQGVRGKTLGIVGAGRIGTAMALMSRGFDMRVLYTSSSG 180 Query: 182 -IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 L ++ LL +D +S+H P P T+++ A MK + ++N +R Sbjct: 181 RRNAVLEDTLKARLVPFDTLLAEADFISIHTPLTPDTRHLFDAAAFGRMKRTACIVNTAR 240 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G V+ L DAL + +AGA +DVF EPA L DN ++ PHIG +T E+ Sbjct: 241 GPVIKEDDLVDALKNGVIAGAGLDVFEREPAMAPG-----LAGLDNAVVLPHIGSATVES 295 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRR 339 + ++ A ++ + +N R Sbjct: 296 RTDMATLAARNMLAMLAGQRPETCLNPDIFGPAFFDAER 334 >UniRef50_A6G5P3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6G5P3_9DELT Length = 405 Score = 396 bits (1019), Expect = e-109, Method: Composition-based stats. Identities = 192/405 (47%), Positives = 260/405 (64%), Gaps = 12/405 (2%) Query: 16 VEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESI-----RDAHFIGLRSRTHLTEDVI 70 E +H A ++ A + L E++ E++ IG+RS+T + + Sbjct: 2 SESIHASASDAFERA-DVQVHRTSAGLGPEEIIEALNGLPGDGPVMIGVRSKTKVRAPIF 60 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A +L A+G FCIGT+Q+DL+ AA+ G+ VFNAPFSNTRSVAELVI E++ L R + E Sbjct: 61 EAVPRLAAVGAFCIGTDQIDLEVAAQSGVAVFNAPFSNTRSVAELVIAEIVCLSRQLFER 120 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + AH G W K A G+ E RGK LGIIGYGHIG+QL +LAE++G+ V ++DI NKLPLGN Sbjct: 121 SWAAHEGRWRKDAKGAHEVRGKTLGIIGYGHIGSQLSVLAEAMGLRVRYHDIVNKLPLGN 180 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 A+ + L LL SD VSLHVP P T+NM GA E++ MKPG+ LINASRGTVVDI AL Sbjct: 181 ASASESLDALLAGSDFVSLHVPNTPQTRNMFGAAELAKMKPGAYLINASRGTVVDIEALR 240 Query: 251 DALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAG 310 +L S H+AGAA+DV+P EP + +DPF SPL V+LTPHIGGSTQEAQ NIG+EV+ Sbjct: 241 ASLESGHVAGAALDVYPKEPKSTADPFESPLQGLRQVILTPHIGGSTQEAQANIGVEVSE 300 Query: 311 KLIKYSDNGSTLSAVNFPEVSLPL--HGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 L Y+ G T + P + P G RL++IH + PGVLT+ N+ ++ G+NI Q Sbjct: 301 ALAAYTRFGRTTGCITLPAIDAPAISPGRSRLLNIHRDVPGVLTSANQRVSDAGLNITGQ 360 Query: 369 YLQTSAQMGYVVIDIEADEDVA--EKALQAMKAIPGTI--RARLL 409 L+T A +G +++D++A D E + + ++ R RLL Sbjct: 361 RLETQAGVGLLLMDVDAKSDDPRVESLRADLAGLAQSLPRRTRLL 405 >UniRef50_D2C7W6 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Thermotoga naphthophila RKU-10 RepID=D2C7W6_THENR Length = 329 Score = 396 bits (1018), Expect = e-109, Method: Composition-based stats. Identities = 115/323 (35%), Positives = 169/323 (52%), Gaps = 20/323 (6%) Query: 12 KFLLV----EGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 K ++ ++ ++ L G+ + K +E+L+E+I+DA + + + T +T Sbjct: 3 KVVVATRTFGRYTKEPIDYLERNGFVVLRVEK----EEELREAIKDAEALIVGTHT-VTR 57 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 ++I ++ L I +G + +D++AA ++GIPV +N+ SVAEL I + L RG+ Sbjct: 58 EMIESS-NLKVIAKHGVGVDNIDVEAATEKGIPVTITLGANSLSVAELTIAFIFALSRGL 116 Query: 128 PEANAKA-HRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL 186 A+ K + W E GK +G+IG+G IG ++ A LGM V YD Sbjct: 117 IWAHNKLFYEKKWE--GYVGQEVSGKVMGVIGFGSIGREVVKKAVCLGMNVLVYDPYVSK 174 Query: 187 P---LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 L AT V L LL SD VSLHVP N STKNM+G +E+SLMK + LIN SRG + Sbjct: 175 DSVRLLEATPVDDLEQLLKESDFVSLHVPLNESTKNMIGERELSLMKKSAFLINTSRGEL 234 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 VD AL AL +AGAA+DVF EP SPL E N++ T HIG T+EA Sbjct: 235 VDEEALVKALKEGRIAGAALDVFSEEPPDA----NSPLFECPNLITTAHIGAHTKEAIFR 290 Query: 304 IGLEVAGKLIKYSDNGSTLSAVN 326 + + A ++ + VN Sbjct: 291 MNMMAAQSIVDFFKGRIPRYVVN 313 >UniRef50_B3T9W6 Putative D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein n=1 Tax=uncultured marine microorganism HF4000_APKG7H23 RepID=B3T9W6_9ZZZZ Length = 491 Score = 396 bits (1018), Expect = e-109, Method: Composition-based stats. Identities = 105/332 (31%), Positives = 165/332 (49%), Gaps = 12/332 (3%) Query: 49 ESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSN 108 E I + +RS T +T +I A L IG +G + VDLDAA ++GIPV NAP N Sbjct: 3 EIIGGYEALIVRSETQVTAGLIEAGGHLQVIGRAGVGVDNVDLDAATRQGIPVVNAPTGN 62 Query: 109 TRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGI 168 T + AE + +L ++R +P+A+A G W + A E RGK LGIIG G +G+++ Sbjct: 63 TVAAAEHTLALMLAMVRHIPQADASVRMGEWRRSAFMGVEVRGKILGIIGLGKVGSEVAR 122 Query: 169 LAESLGMYVYFYDIENKLPLGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEI 226 +L M + +D ++ L L+ +D +++H P +T+ ++G + Sbjct: 123 RTRALQMRILAHDPFVPQESARSLGVEMVSLDQLMAEADFITIHTPLTATTQQLLGPAQF 182 Query: 227 SLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDN 286 +K G +INA+RG +V+ L +AL S +AGAA+DVF EP SPL + Sbjct: 183 QQLKHGVRIINAARGGLVNEQLLLEALESGRVAGAALDVFVEEPPKQ-----SPLLQHPR 237 Query: 287 VLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHEN 346 V+LTPH+G ST+EAQ + LE+A +++ S VN P + + Sbjct: 238 VVLTPHLGASTEEAQTEVALEIADQVLAVLAGSSAQYTVNVPYIPEEVREALAPFIP--- 294 Query: 347 RPGVLTALNKIFAEQGVNIAAQYLQTSAQMGY 378 L + AE + L S ++ + Sbjct: 295 VATFLGKVAIQLAE--GQFESLTLSYSGEIAH 324 Score = 61.5 bits (149), Expect = 6e-08, Method: Composition-based stats. Identities = 22/86 (25%), Positives = 41/86 (47%) Query: 324 AVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDI 383 VN + L G + H +RPG++ + I E +NI+ + A G + + Sbjct: 404 RVNDFSLDLQPTGRFMMFTEHTDRPGMIGRMGTIAGEHDINISFMEVGRRAPRGEATMIV 463 Query: 384 EADEDVAEKALQAMKAIPGTIRARLL 409 D+ ++++AL +AIP R R++ Sbjct: 464 GLDDPISDEALAEFRAIPHVSRVRVV 489 >UniRef50_C0GLG9 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Desulfovibrionales RepID=C0GLG9_9DELT Length = 394 Score = 396 bits (1018), Expect = e-109, Method: Composition-based stats. Identities = 121/401 (30%), Positives = 189/401 (47%), Gaps = 14/401 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 ++ L +G+ +A+ LR G++ D E L + D + +RS T + ++I Sbjct: 1 MRILANDGLVDEAVNFLRREGFSV---DTEKRDYEDLLGDLPDFDALLVRSATKVNRELI 57 Query: 71 NAAE----KLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 AA KL IG +GT+ +DL AA + G+ V AP N + AE VIG + + R Sbjct: 58 EAATTKRGKLKIIGRGGVGTDNIDLQAAKECGVVVKFAPHGNINATAEHVIGLMFAIARK 117 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL 186 VP A+ G+W+K E +GK LG+IG G IG + A+ L M V +D + Sbjct: 118 VPFAHHTLKSGIWHKARFKGVELQGKTLGLIGCGRIGQAVANKAKDLDMKVIGFD-MQRW 176 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + + ++L+ +D VS++ ++ E+ MK + LINASRG V+ Sbjct: 177 MDSEVDYMDSMEEVLDHADFVSIN---TGGAHTLIREPELERMKSSAFLINASRGVNVEE 233 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL AL + +AGAA+D + EP +PFTS L E DN++L+ H+G ST A G+ Sbjct: 234 DALYYALKNGRIAGAALDCYEKEPKREGEPFTSKLAELDNIVLSAHLGASTANAARKTGM 293 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEVSLPLH-GGRRLMHIHENRPGVLTALNKIFAEQGVNI 365 E+A + KY G +VN + + + HE++PG+ F + GVNI Sbjct: 294 EIADVVSKYLKYGDFRQSVNVGQTVIDEGIDLYTIFITHEDKPGMFGKFGTAFGDLGVNI 353 Query: 366 AAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRA 406 Q + G E + + + I G R Sbjct: 354 --QENNSRRLDGLAQTIYTIQEKPTSEMQEKLLEIDGVRRV 392 >UniRef50_B9L1V2 Glyoxylate reductase n=2 Tax=Thermomicrobia (class) RepID=B9L1V2_THERP Length = 333 Score = 395 bits (1017), Expect = e-108, Method: Composition-based stats. Identities = 107/309 (34%), Positives = 153/309 (49%), Gaps = 11/309 (3%) Query: 21 QKALESLRAAGYTNIEFH-KGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAI 79 ++ L G +E + +D+EQL E +RD + + +T V+ A +L I Sbjct: 26 EEIARFLEERGCRFVEKEIRYPVDEEQLCELVRDVDGLVV-GLEPITARVLAHANRLKVI 84 Query: 80 GCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVW 139 +G + +D+ A +RGI V N +N SVAEL G +L L RG+ ++ G W Sbjct: 85 STSGVGFDNIDVAEATRRGIVVANCHGANEHSVAELAFGLMLALARGIHRSDRLMREGRW 144 Query: 140 NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQ--VQHL 197 E GK LG+IG G G + +L GM V +DI NA + L Sbjct: 145 E--PYFGVELWGKTLGVIGLGRAGRAVALLGRGFGMRVLAHDIVWDTTFANAHEISYVPL 202 Query: 198 SDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKH 257 LL SD VSLHVP P T+ ++ + +SLMKP + LIN +RG VV AL +AL Sbjct: 203 EKLLRESDFVSLHVPLTPDTRYLIDERALSLMKPTAFLINLARGPVVKQSALVEALRRGQ 262 Query: 258 LAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSD 317 +AGA +DVF EP +P EF+NV++TPH+GGST+EA+E + + Sbjct: 263 IAGAGLDVFEVEPIR-----DNPFVEFENVVMTPHLGGSTEEARERTLYLALTNVCNVLN 317 Query: 318 NGSTLSAVN 326 VN Sbjct: 318 GRPPHHQVN 326 >UniRef50_B8I0H1 D-3-phosphoglycerate dehydrogenase n=13 Tax=Clostridia RepID=B8I0H1_CLOCE Length = 535 Score = 394 bits (1014), Expect = e-108, Method: Composition-based stats. Identities = 106/395 (26%), Positives = 178/395 (45%), Gaps = 15/395 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K ++ E + + + L+ G+ + + E+L E+I D I +RS T + E+++ Sbjct: 1 MKIIVTERIAEDGINYLKENGHEV--DTRYGISHEELLETIEDYDAIIVRSVTKVNEELL 58 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A KL G G + +++ A KRGI V N P SN + AEL +G + R +P+A Sbjct: 59 QRASKLKVAGRAGNGIDNIEVPACTKRGIIVVNTPESNIMAAAELAVGHAYAIFRNIPQA 118 Query: 131 NAKAHR-GVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL- 188 + + + E K GIIG G IG+ + + M V YD Sbjct: 119 HWAGKAQNDFRRSRFNGNELDEKTAGIIGLGRIGSIVATKLKGSNMKVIAYDPYITDEKF 178 Query: 189 --GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + L +LL SD++SLH P+ T M+G +++ L K ++NA+RG +V+ Sbjct: 179 KKLGVERCDTLEELLKQSDLISLHTPKTSETYGMIGEEQLKLCKKDVRIVNAARGGLVNE 238 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFT----SPLCEFDNVLLTPHIGGSTQEAQE 302 AL +A+ H+A AA+DV EP + P + L E DNV++TPH+G ST EA Sbjct: 239 EALYNAIKEGHVAAAALDVLDPEPNYDKKPEDQDYQNKLFELDNVIITPHLGASTAEANY 298 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQG 362 N+G V+ + AVN P + + +L + ++ Sbjct: 299 NVGTAVSKLVSDALKGEMVA-AVNMPPMKNKDLNEMKPYLDLAE---ILGKIYYQAEKET 354 Query: 363 VN-IAAQYLQTSAQMGYVVIDIEADEDVAEKALQA 396 VN I Y A+ ++ + + + ++ Sbjct: 355 VNKIEIVYSGELAEQETKILSLSVLKGFLDIVIKE 389 Score = 50.0 bits (119), Expect = 1e-04, Method: Composition-based stats. Identities = 17/76 (22%), Positives = 31/76 (40%) Query: 334 LHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKA 393 L + + PG++ + I +NIAA + + V + D +V Sbjct: 458 EPTPYVLAIQNVDVPGIIGQIGTILGASDINIAAMQWSRNHKGEKAVAFVSVDCEVPANV 517 Query: 394 LQAMKAIPGTIRARLL 409 L+ +K I G ++ LL Sbjct: 518 LELLKKINGVLKVTLL 533 >UniRef50_UPI00016C495D phosphoglycerate dehydrogenase n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C495D Length = 539 Score = 394 bits (1013), Expect = e-108, Method: Composition-based stats. Identities = 116/369 (31%), Positives = 185/369 (50%), Gaps = 14/369 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ + + +E L+AAG ++ L ++LK +I+ A + RS+ L+ + + Sbjct: 3 RVLIADKLESSGIELLQAAGIEV--DNRPGLKGDELKAAIQAADAVICRSQPKLSAEYFD 60 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 K+ A+ +G + +D+ AA ++G+ V N P NT S AE I LL L R +P A+ Sbjct: 61 NPGKMRAVARAGVGVDNIDVAAATRKGVVVMNTPGGNTVSAAEHTIALLLALSRRIPAAD 120 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE---NKLPL 188 A G W++ E GK LG++G G IG ++ A+ L M V D K+ Sbjct: 121 ATMKAGGWDRNKFVGTEVAGKVLGVVGLGRIGREVARRAKGLDMKVIALDQFVTAAKVAE 180 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 L +LL D ++LHVP TK+M+GA+E+ LMK + ++N +RG ++D A Sbjct: 181 LGYESAASLDELLPKVDYLTLHVPGGAETKSMVGARELGLMKKTARVLNVARGGIIDEKA 240 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +ALA+ +AGA +DVF EP + PL + N+++TPH+G ST EAQEN+ +E Sbjct: 241 LAEALAAGTIAGAGVDVFSVEPIAADN----PLAKAPNIVITPHLGASTLEAQENVAVEA 296 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 A + + +G +AVN V+ R R G+L A I Sbjct: 297 AQLIKDFLLSGQVANAVNMAAVNPAELAEVRPYVDLARRLGLLQAQVAQ-----GAIRKA 351 Query: 369 YLQTSAQMG 377 L ++ Sbjct: 352 SLTYRGELA 360 Score = 46.1 bits (109), Expect = 0.003, Method: Composition-based stats. Identities = 18/82 (21%), Positives = 36/82 (43%) Query: 328 PEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADE 387 P G L+ H + PG++ + IF + VNIA + ++ G + + D Sbjct: 445 PFRMEGYLDGVLLVFRHHDVPGLIGFVGTIFGKHKVNIAQMTVGRTSPGGEAIGILNLDN 504 Query: 388 DVAEKALQAMKAIPGTIRARLL 409 +++A+ +KA P ++ Sbjct: 505 WPSDEAVAEVKAHPQISSVTVV 526 >UniRef50_A7SFV8 Predicted protein (Fragment) n=1 Tax=Nematostella vectensis RepID=A7SFV8_NEMVE Length = 487 Score = 393 bits (1011), Expect = e-108, Method: Composition-based stats. Identities = 105/368 (28%), Positives = 165/368 (44%), Gaps = 13/368 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + L+ + V L G T L E+L I + +RS T ++EDVI Sbjct: 7 KRVLISDSVDSCCKTILERNGVTV--DVNTKLSKEELVSEIPKYDGLIVRSATKVSEDVI 64 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A + L IG G + +D AA+ G+ V N P NT S AE + L R +P+A Sbjct: 65 KAGKNLKIIGRAGTGVDNIDTVAASLHGVLVMNTPGGNTLSAAEHTCALISSLARHIPQA 124 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--ENKLPL 188 +A G W + E GK L IIG G IG ++ + +S G+ YD + Sbjct: 125 SASTKEGKWERKQFMGNELFGKTLAIIGLGRIGREVALRMQSYGVKTIGYDPLVSPQDAA 184 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + + + ++D +++HVP P TK M+ K I + K G ++N +RG ++D A Sbjct: 185 ESNIEWMETEKIWPLADYITVHVPLIPPTKGMLNDKTIGMCKKGVYILNVARGGIIDEEA 244 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L L S H+ GA +DVF TEP T S ++ L + V+ PH+G ST+EAQ + E+ Sbjct: 245 LLRGLESGHVGGAGLDVFVTEPPTGS---SADLVKHPKVIACPHLGASTEEAQRRVAQEI 301 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 A + + + + VN P +L + + R G + G + Sbjct: 302 ADQFVDGMNGKPLIGLVNVPF-NLSEALNSKPLVTLGERLGKVARTL-----AGGTVTKA 355 Query: 369 YLQTSAQM 376 + T + Sbjct: 356 IVTTHGAL 363 >UniRef50_A6CKS4 Putative uncharacterized protein n=2 Tax=Bacillaceae RepID=A6CKS4_9BACI Length = 322 Score = 393 bits (1011), Expect = e-108, Method: Composition-based stats. Identities = 103/325 (31%), Positives = 166/325 (51%), Gaps = 11/325 (3%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K L+ + + ++ ++ L G I ++E L + D I +R L+ V Sbjct: 2 NFKVLIPQPIAKEGIDLLEKEGAEVI--IPPDYNEETLISHVSDVDAILIR-TAKLSRVV 58 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I A KL I IG + +DL+AA+ RGI V NAPF+N +VAE V+ +L R + + Sbjct: 59 IEKASKLKVIARHGIGVDNIDLEAASDRGILVTNAPFANVNAVAEHVLTLILSGSRQLIQ 118 Query: 130 ANAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIENKLP 187 ++ G + + E +GK LG++G+G+IG + LGM V YD + Sbjct: 119 VDSALRNGDFEVRNRKFGIELKGKTLGVVGFGNIGQLVAEKCHYGLGMDVLVYDPYVREE 178 Query: 188 -LGNATQV-QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 + + Q+ Q LS++L SD+V++HVP PST +++ + + MK ++L+NA+RG ++D Sbjct: 179 NVSSYVQLNQSLSEVLASSDIVTIHVPYLPSTHHLINEEALQQMKKDAILVNAARGGIID 238 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL AL S + GA +D F TEP L +NV++TPH+ T+EA + Sbjct: 239 EIALEKALGSGEIRGACLDCFETEPPA----VDHSLWNLENVIVTPHLAAHTEEAMIEMA 294 Query: 306 LEVAGKLIKYSDNGSTLSAVNFPEV 330 + A +I L VN E+ Sbjct: 295 VTPAKDIIAIMKGEKPLYPVNEKEI 319 >UniRef50_Q18DJ4 Phosphoglycerate dehydrogenase n=13 Tax=Halobacteriaceae RepID=Q18DJ4_HALWD Length = 534 Score = 392 bits (1009), Expect = e-107, Method: Composition-based stats. Identities = 117/392 (29%), Positives = 181/392 (46%), Gaps = 22/392 (5%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 ++ L+ + + LE LRAAG+ + + DE L +I D + + +RS T + E V Sbjct: 3 MQVLVTDPIDDAGLERLRAAGHGVETAYD--IGDEALLNTITDVNALVVRSGTDVNEAVF 60 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA L+ +G IG + +D+DAA + G+ V NAP N R+ AE + R +P+A Sbjct: 61 EAASDLIIVGRAGIGVDNIDIDAATEHGVIVANAPEGNVRAAAEHTVAMTFAGARSIPQA 120 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 +A+ G W K E GK LG++G G +G ++ ESLGM + YD Sbjct: 121 HARLRTGEWAKSEYLGTEVNGKTLGVVGLGRVGQEVAKRLESLGMDLVAYDPYISEDRAE 180 Query: 191 --ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 ++ L ++ +++H P T M+ E+ LM G LIN +RG VVD A Sbjct: 181 RLGAELVEFDTCLERAEFLTVHTPLTSETAGMISTTELELM-DGGYLINCARGGVVDEDA 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L A+ L GAA+DVF EP S L DN+++TPH+G ST+ AQEN+ + Sbjct: 240 LAAAVEDGVLDGAAVDVFADEPVAPD----SALLSVDNIVVTPHLGASTEAAQENVATSI 295 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQ 368 A ++ ++A+N P V + R G + A I++ Sbjct: 296 ADQIDAAFAGAPVMNALNAPSVDESVFPRIRPYIDLAETAGKIAAQLL-----DGRISSV 350 Query: 369 YLQTSAQMGYVVIDIEADEDVAEKALQAMKAI 400 + + DEDV A+K + Sbjct: 351 SVSYEGDIA--------DEDVELATASALKGV 374 Score = 49.2 bits (117), Expect = 3e-04, Method: Composition-based stats. Identities = 18/81 (22%), Positives = 33/81 (40%), Gaps = 2/81 (2%) Query: 330 VSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTS-AQMGYVVIDIEADED 388 V HG L+ + ++PGV+ + + E +NIA + + G + D+ Sbjct: 446 VDAVPHGKM-LVARNADKPGVIGFIGSVLGEHNINIAGMFNARRDIEGGEALTIYNLDDS 504 Query: 389 VAEKALQAMKAIPGTIRARLL 409 V ++ + A I R L Sbjct: 505 VPTDVVERLLADERMIDVRYL 525 >UniRef50_A5IK90 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=6 Tax=Thermotogaceae RepID=A5IK90_THEP1 Length = 327 Score = 392 bits (1007), Expect = e-107, Method: Composition-based stats. Identities = 113/324 (34%), Positives = 161/324 (49%), Gaps = 22/324 (6%) Query: 11 IKFLLV----EGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLT 66 K L+V Q+ +E L+ G+ I D +++ + + + +T Sbjct: 2 KKVLIVTRTFGKYSQEPVEFLKKEGFEIIRSDTIDPD------ILKEVDALIVGTH-PVT 54 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 ++I + L I +G + +DL+AA K+GIPV +N+ SVAEL I + L+RG Sbjct: 55 AEMIENS-SLKVIAKHGVGVDNIDLEAATKKGIPVTITAGANSLSVAELTIAFIFALIRG 113 Query: 127 VPEANAKA-HRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 + A+ K W E GK LG++G+G IG ++ A LGM V YD Sbjct: 114 LVWAHNKLFLERKWE--GTVGQEVSGKTLGVVGFGSIGREVVKKAVCLGMNVLVYDPYVS 171 Query: 186 LP---LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 L AT V L LL SD VSLHVP N STKNM+G +E+SLMK + LIN SRG Sbjct: 172 KDNVRLLEATPVDDLDQLLKESDFVSLHVPLNESTKNMIGERELSLMKKSAFLINTSRGG 231 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 +VD AL AL +AGAA+DVF EP SPL + N++ T HIG T+E+ Sbjct: 232 LVDEEALVKALKEGRIAGAALDVFSEEPPNP----NSPLFKCPNLITTAHIGAHTKESIL 287 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVN 326 + + A ++ + VN Sbjct: 288 RMNMMAAQSVVDFFKGNIPKYVVN 311 >UniRef50_C4DLZ3 Lactate dehydrogenase-like oxidoreductase n=1 Tax=Stackebrandtia nassauensis DSM 44728 RepID=C4DLZ3_9ACTO Length = 324 Score = 392 bits (1007), Expect = e-107, Method: Composition-based stats. Identities = 102/326 (31%), Positives = 152/326 (46%), Gaps = 14/326 (4%) Query: 8 KDKIKFLLVEGV---HQKALESLRAAGYTNIE--FHKGALDDEQLKESIRDAHFIGLRSR 62 + L+ + L AG + F+ L + I + Sbjct: 1 MANKRVLVTTAWLSPGDEVHRLLTDAGCDVVHSSFNDRDSSPATLAALVTGFDGI-VAGT 59 Query: 63 THLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLL 122 + +VI AA++L G +G + +D+ AA +RGI V P N +SVAE LL Sbjct: 60 DRFSAEVIAAADRLKVFGRTGVGYDNIDVAAATERGIAVCPTPGVNRQSVAEHTFALLLS 119 Query: 123 LLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI 182 + RGVP G W +++ E G LG+IG G IG + +A GM V +D Sbjct: 120 VARGVPGNVTAVAAGDWPQVS--GRELSGATLGLIGLGAIGKAVARIALGFGMRVIAHDP 177 Query: 183 ENKLPL--GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 + + L +LL +D VSLH+ + +T++++ A+ I+ MKPG+ L+N SR Sbjct: 178 YLDAEAVAASGVERASLDELLATADFVSLHIFLDDATRHLIDAEAIATMKPGAYLVNTSR 237 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G VVD AL AL L+GA +DV TEP P SPL DN+++T HIG +T E+ Sbjct: 238 GGVVDETALAAALREGRLSGAGLDVLETEPL----PPDSPLRGLDNLIITAHIGAATVES 293 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVN 326 + G A +I D + VN Sbjct: 294 RARSGRMAAQAVIDVLDGRTPEHVVN 319 >UniRef50_A8A9G4 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=3 Tax=Archaea RepID=A8A9G4_IGNH4 Length = 308 Score = 391 bits (1006), Expect = e-107, Method: Composition-based stats. Identities = 120/308 (38%), Positives = 170/308 (55%), Gaps = 8/308 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ + VH LE LR G +E + A E LKE I+ + +RSRT + +VI Sbjct: 3 RALVTDKVHPAGLELLREKGIEVVEDLE-AYKPEVLKERIKGFDVLIVRSRTKVRREVIE 61 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AA+KL I G + +DL+AA ++GI V NAP + +VAELVIG +++L R + Sbjct: 62 AADKLKVIARAGSGLDNIDLEAAKEKGIKVVNAPDALKNAVAELVIGMMVVLARRAHYSY 121 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 K G W K+ FE GK LG++G+G IG ++ A++LGM V YD+ + Sbjct: 122 RKLLEGEWEKV--MGFELAGKTLGVVGFGRIGREVAKKAKALGMNVIAYDVVDLSETAKE 179 Query: 192 TQVQ---HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 V+ L +LL SDVVSLHVP T+NM+ I +MK G++LINA+RG V D A Sbjct: 180 MGVEFTQDLEELLRKSDVVSLHVPLTEQTRNMINRDRIKIMKDGAILINAARGEVADYSA 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +AL S L G +DV+P EP + + L T HIG T+EAQ LEV Sbjct: 240 LLEALESGKLWGVGLDVYPEEPPKSEELL--KLIRHPRTFATAHIGAQTEEAQRRTSLEV 297 Query: 309 AGKLIKYS 316 A ++++ Sbjct: 298 AQRILEAL 305 >UniRef50_Q1K3M3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Desulfuromonas acetoxidans DSM 684 RepID=Q1K3M3_DESAC Length = 528 Score = 391 bits (1005), Expect = e-107, Method: Composition-based stats. Identities = 100/358 (27%), Positives = 172/358 (48%), Gaps = 7/358 (1%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 ++ L+ + L+ A ++ + + L + I + + +R T ++E++I Sbjct: 1 MQVLISDNFSSAGLKLFDEA-EGITADYQPGITHDNLLKIINNYDALIVRGGTTVSEELI 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA++L I IG + +DAA +GI V N P +T ++AE I ++ L R +P+A Sbjct: 60 FAAKRLKIIARAGIGVENIAMDAANIKGIVVTNTPLGSTTTIAEHAIAMMMSLARLIPQA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG- 189 + +G W + K LG+IG G IG ++ A L M+V YD + Sbjct: 120 HESMSQGKWQSTEFLGSDINDKTLGVIGGGKIGRRVIEYARGLHMHVNLYDPYLSEEVIT 179 Query: 190 -NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 L DLL+ +D +SLH+P T+ ++ A+ +++KPG LIN + G +++ Sbjct: 180 RLGASKVSLEDLLSTADFISLHLPLTLETEQILNAETFAMVKPGCRLINCALGGLINEDD 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L +AL AGAA+D F TEP + L DNV+ TPH+ +T +AQ N+ ++ Sbjct: 240 LVNALTDGTFAGAALDTFATEPPAPDN----RLLHMDNVICTPHLRAATVDAQTNVTVQA 295 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIA 366 A ++I + N + +A+N P +S+ R R G+ A + I Sbjct: 296 AHQVIDFLTNKTVRNALNVPSISIDHLEAMRPYLDMAERMGLFLAQLLHMPFNAITIE 353 Score = 42.7 bits (100), Expect = 0.026, Method: Composition-based stats. Identities = 21/122 (17%), Positives = 44/122 (36%), Gaps = 14/122 (11%) Query: 299 EAQENIGLEVAGKLIKYSDNGSTLSAV-----NFPEVS---------LPLHGGRRLMHIH 344 E + N+ + + +V N E + G L+ + Sbjct: 401 ETRRNVADGFSNMIELIVSGEQGSQSVRGAIFNNRECRIIGVDDYAIETIPSGHLLVVRN 460 Query: 345 ENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTI 404 +RPGV+ L ++ AE +N+A L G + + D + E+ ++ ++ + Sbjct: 461 LDRPGVIALLGRLLAEAEINVAMMNLSRQKSTGDAMSLVTVDHKIPEQVMEELRRHDSIL 520 Query: 405 RA 406 A Sbjct: 521 SA 522 >UniRef50_A1HSQ7 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Thermosinus carboxydivorans Nor1 RepID=A1HSQ7_9FIRM Length = 317 Score = 388 bits (997), Expect = e-106, Method: Composition-based stats. Identities = 102/321 (31%), Positives = 152/321 (47%), Gaps = 15/321 (4%) Query: 12 KFLLVEGV---HQKALESLRAAGYTNI-EFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 K L+ +A L AG I + L +++L E I+ + + +T Sbjct: 3 KVLVTARSFAKSPEARAVLEQAGCEVIFNPYDRPLTEDELVELIKGMDAL-VAGMDAVTA 61 Query: 68 DVINA-AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 VI A L I +G N +D+ AAA GIPV P +N SVAEL IG +L + R Sbjct: 62 KVIAAGLPTLKIIAKHGVGYNTIDVAAAAAYGIPVTITPGANNISVAELAIGLMLAVARH 121 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL 186 +P+ + RG W++ E GK LGIIG G IG ++ A + GM + YDI + Sbjct: 122 IPQMDGIVRRGGWSR--MTGSELYGKVLGIIGMGSIGCEVAKRAHAFGMKIIAYDIRPRQ 179 Query: 187 PLGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + ++D L +D +SLH P P T M+ + MK + LIN +RG ++ Sbjct: 180 DMIENYGVTYLPMADCLAQADFLSLHAPALPETIGMINKDTLKTMKRTAFLINTARGDLI 239 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 L DAL + +AGA +D F EP + L DNV+LTPH G +T EA + Sbjct: 240 VEEDLYDALKNGVIAGAGLDTFVHEPIR-----DARLFTLDNVVLTPHAGATTHEAVTRM 294 Query: 305 GLEVAGKLIKYSDNGSTLSAV 325 G+ A ++++ + V Sbjct: 295 GVMAAEEVVRVLSGQPPQNPV 315 >UniRef50_B0KD78 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=8 Tax=Bacteria RepID=B0KD78_THEP3 Length = 332 Score = 387 bits (996), Expect = e-106, Method: Composition-based stats. Identities = 100/338 (29%), Positives = 155/338 (45%), Gaps = 14/338 (4%) Query: 8 KDKIKFLLVEGVHQKAL---ESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTH 64 ++K ++ + + E L AG T + +E+L + +DA + Sbjct: 1 MSQLKVVVTDFEYANLKYEEEVLSKAGITLVPAQCK--TEEELILACKDADGLI-NQYAK 57 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 +T VI A +K I + IG + +D+ AA RGI V N P V++ + LL Sbjct: 58 ITRRVIEALDKCKVIARYGIGVDTIDIKAATARGICVVNVPDYCMDEVSDHALALLLGCA 117 Query: 125 RGVPEANAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE 183 R V N G W+ K++ + RGK LG++G+G I L A G + YD Sbjct: 118 RKVVLMNNAVKAGTWDFKISKPIYRLRGKVLGLVGFGRIPRTLAEKARPFGFDILVYDPY 177 Query: 184 NKLP--LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 + L +L++ SD VS+H P T +++G EI LMKP + +IN +RG Sbjct: 178 ITQEDVEPYGATLVGLEELMSKSDFVSVHAPLTEKTYHLIGETEIGLMKPSAFIINTARG 237 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 V+D AL AL K +AGA +DV EP P +PL + DNV++TPH+ ++E++ Sbjct: 238 PVIDEKALIKALQEKRIAGAGLDVLEQEP----TPSDNPLLKMDNVIITPHVAWYSEESE 293 Query: 302 ENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRR 339 + + A + VN EV L R Sbjct: 294 AELRTKAAQGVADVLLGYWPKYLVN-KEVKEKLQLKER 330 >UniRef50_D0MDQ9 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MDQ9_RHOM4 Length = 406 Score = 387 bits (996), Expect = e-106, Method: Composition-based stats. Identities = 124/405 (30%), Positives = 188/405 (46%), Gaps = 13/405 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIR--DAHFIGLRSRTHLTED 68 ++ LL + + + LE+LR G T ++ L + L E++ + + +RS T +T + Sbjct: 1 MQVLLADKLEDRCLEALRGLGLTV--HNRPELKEAALSEALSALNPEILVVRS-TRVTAE 57 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 ++ AA L I G + +D+ AA+ RGI V N P N +VAEL G +L L R +P Sbjct: 58 MMAAAPALELIIRAGAGYDTIDVGAASDRGIFVANCPGKNAVAVAELTFGLILALDRFIP 117 Query: 129 EANAKAHRGVWNKLAA-GSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP 187 E A G WNK A +G+ LG+IG GHIG ++ A + M V + Sbjct: 118 ENVLDAREGRWNKAAYSKGRGLKGRTLGVIGLGHIGREVVRRAHAFEMPVVAWSRSLTDE 177 Query: 188 LGNATQVQHLS---DLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 L V + ++ +D+V++H+ P T+++ MKPG+ IN SR ++V Sbjct: 178 LARELGVVRKNSPLEVAAEADIVTIHLAAAPETRHLANRAFFEAMKPGAYFINTSRSSLV 237 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL AL + + AA+DV EPA S F PL V T HIG ST++AQE I Sbjct: 238 DEEALAWALEHRGIR-AALDVMEGEPAAKSGSFAHPLAGHPQVYFTHHIGASTKQAQEAI 296 Query: 305 GLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVN 364 EV + Y + G + VN E S H L H ++ GVL ++ N Sbjct: 297 ADEVVRIIKTYLETGHAPNCVNLEEHSPATHL---LTVRHLDKVGVLASVLDEVRRANWN 353 Query: 365 IAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 + A I D E +Q + A+P + L+ Sbjct: 354 VQEMENLIFAGARAACARIRFDGRPDEAVVQRIAALPDVLAVSLI 398 >UniRef50_Q4WHR3 D-3-phosphoglycerate dehydrogenase n=3 Tax=Eurotiomycetidae RepID=Q4WHR3_ASPFU Length = 635 Score = 387 bits (996), Expect = e-106, Method: Composition-based stats. Identities = 113/402 (28%), Positives = 183/402 (45%), Gaps = 58/402 (14%) Query: 4 VSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRT 63 +S ++ K L+ E + L LRA+ + + LD ++L + I + + +RS T Sbjct: 2 LSAKQPPPKVLVPEKLSPDGLALLRASLEVD---ERRGLDADELLQIIPEYEALVVRSET 58 Query: 64 HLTEDVINAAEKLVAIGCFCIGTNQV------------------------DLDAAAKRGI 99 +T +++ AA++L + +G + V D++ A K GI Sbjct: 59 KVTANLLRAAKQLKVVARAGVGVDNVGELAQPPLPPSPSLGSWPLTSHRTDVEEATKLGI 118 Query: 100 PVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGY 159 V N+P N + AE I L+ + R +PEA + G W + E +GK L IIG Sbjct: 119 VVVNSPSGNIGAAAEHTIALLMAMARNIPEACSSLKSGKWERSKFVGVEVKGKTLSIIGL 178 Query: 160 GH---------------------------IGTQLGILAESLGMYVYFYDIENKLPLGNAT 192 G +G + LA+ LGM+V D + + Sbjct: 179 GKGELLAIWGRGIHFRYDGGSSGWADRQTVGLTVARLAKGLGMHVNALDPYASPAVAASA 238 Query: 193 Q---VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 V LS+LL +D +++H P STK M+ E++ MKPG+ ++N +RG +D AL Sbjct: 239 SVTLVSSLSELLPTADFLTIHTPLIASTKGMISTAELAQMKPGARILNVARGGTIDEAAL 298 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 ++L S HLA AAIDVF TEP + L ++TPH+G ST EAQEN+ ++V Sbjct: 299 LESLESGHLAAAAIDVFTTEPPQPES-TAARLVAHPRAVVTPHLGASTVEAQENVSIDVC 357 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVL 351 ++++ + SAVN P + + + + G L Sbjct: 358 EQVLQILNGSLPRSAVNAPLILPDEYRKLQPFVRLVEKMGSL 399 >UniRef50_C2HP35 Glyoxylate reductase n=10 Tax=Lactobacillus RepID=C2HP35_LACAC Length = 330 Score = 387 bits (994), Expect = e-106, Method: Composition-based stats. Identities = 95/328 (28%), Positives = 168/328 (51%), Gaps = 14/328 (4%) Query: 7 EKDKIKFLLVEGVHQKALESLRAAGYTNIEF--HKGALDDEQLKESIRDAHFIGLRSRTH 64 +K K L++ G+ AL+ LR+ + H+ D + + ++I + + ++ Sbjct: 9 NMNKAKVLVLGGLIDDALDDLRSTCEVTVGPVGHRPNDDRQWVLKNIAKYDGVIV-AKMI 67 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 +++I+AA+ L I + +G + +D+D A ++GI V N P S R AEL + ++ Sbjct: 68 FDKEIIDAAKNLKVISTYGVGFDHIDIDYAREKGIVVTNCPNSVLRPTAELALTMIMASA 127 Query: 125 RGVPEANAKAHRGVW---NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD 181 R + + GV+ ++ + + GK LGI+G G IG Q+ A++LGM + +++ Sbjct: 128 RRIRYYDHALREGVFLNVDEYDSQGYTIEGKTLGILGMGRIGQQVARFAKALGMKIIYHN 187 Query: 182 IE---NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINA 238 +L + + L+ SD +SLH P T +++ + MK S LIN Sbjct: 188 RHQLKPELEAELNARYVDFASLVKNSDFLSLHAPATDETYHIIDKDVFNNMKDTSFLINV 247 Query: 239 SRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQ 298 +RG++VD L AL +AGAA+DVF EP D L DNV++TPH+G +T Sbjct: 248 ARGSLVDSDDLVAALKEGKIAGAALDVFENEPYPKQD-----LVNMDNVIMTPHVGSATH 302 Query: 299 EAQENIGLEVAGKLIKYSDNGSTLSAVN 326 +A+ N+ E A ++ + G +++VN Sbjct: 303 KARYNLTKEAANNILTFFKEGKVINSVN 330 >UniRef50_A7GQE1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Firmicutes RepID=A7GQE1_BACCN Length = 390 Score = 387 bits (994), Expect = e-106, Method: Composition-based stats. Identities = 113/415 (27%), Positives = 188/415 (45%), Gaps = 43/415 (10%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + + +K L+ A Y + + I I LRS + E++ Sbjct: 2 FHIQTLNQIAEKGLQVFAAERY-------------NIGQRIEHPDGILLRSYSLHQEEL- 47 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 ++ L AI G N + +D ++GI VFN P +N +V EL++ +L R + Sbjct: 48 --SKNLKAIARAGAGVNNIPIDRCTEKGIVVFNTPGANANAVKELILASFILSSRNIING 105 Query: 131 NAKAH--RGVW-------NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD 181 + G K E GK+LG+IG G IG + A SLGM V YD Sbjct: 106 VSWTKGLEGKEIPQLVEAGKKQFVGSEIAGKRLGVIGLGAIGALVANDALSLGMDVVGYD 165 Query: 182 IENKLPLG-----NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLI 236 + + + L ++ D ++LH+P T+ ++G + +MK G L Sbjct: 166 PYISVETAWRLSTHVQRAFSLDEIFATCDYITLHIPLTEQTRGIIGEHAVRMMKKGVRLF 225 Query: 237 NASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGS 296 N SRG +VD AL AL + + D FP E + + NV+ TPH+G S Sbjct: 226 NFSRGELVDETALEKALEEETINHYMTD-FPNE----------NVIKMKNVVATPHLGAS 274 Query: 297 TQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNK 356 T E++EN + A +L Y + G+ ++VN+P V LP G +R+ +H+N P ++ + Sbjct: 275 TYESEENCAVMAACQLRDYLETGNIRNSVNYPNVELPYVGKKRITIMHQNVPNMVGQITG 334 Query: 357 IFAEQGVNIAAQYLQTSAQMGYVVIDIE--ADEDVAEKALQAMKAIPGTIRARLL 409 AE +NIA ++ Y +IDI+ D+ + E ++ ++ I G + R++ Sbjct: 335 CLAEHHINIADMINRSKNSWAYTMIDIDNGMDDRMKENIVENIRRITGVVAVRMI 389 >UniRef50_C4XIX3 Putative D-isomer specific 2-hydroxyacid dehydrogenase n=1 Tax=Desulfovibrio magneticus RS-1 RepID=C4XIX3_DESMR Length = 329 Score = 386 bits (993), Expect = e-106, Method: Composition-based stats. Identities = 88/335 (26%), Positives = 141/335 (42%), Gaps = 12/335 (3%) Query: 6 LEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 + K ++ + + L LR + L ++L +DA + + Sbjct: 1 MTKPLPHVVVTRAIPEAGLALLRERATVWVNPEDRPLTRDELLAQAKDADGVIGLLTDRI 60 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 +A KL + +G + +D+ A +RG+PV N P T++ AEL +L R Sbjct: 61 DAGFFDACPKLRGYANYAVGYDNIDVPEATRRGLPVSNTPDVLTQATAELAFALILATAR 120 Query: 126 GVPEANAKAHRGVWNKL---AAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD- 181 + ++A G W+ + GK LGI G G IG + L+ M + Sbjct: 121 HIVASDAVLRSGQWSGWGPLQFIGTQLAGKTLGIYGPGRIGLAVARLSRGFDMKIITCGG 180 Query: 182 --IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINAS 239 L L +DVVS+ P +T++ A + MKP +LL+N Sbjct: 181 RKPNPALVAEFGAASLPFEAFLAAADVVSITAPLTDTTRHAFNAAAFARMKPTALLVNTG 240 Query: 240 RGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQE 299 RG ++D AL AL +AGA +DV+ EP L NV++TPHIG +T E Sbjct: 241 RGPIIDEAALVVALREGRIAGAGLDVYEFEPRLAEG-----LAALPNVVITPHIGSATTE 295 Query: 300 AQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPL 334 A+E + + A LI + + + +N PEV Sbjct: 296 AREGMAVLAAQNLIAMLEGTTPPTCLN-PEVLARP 329 >UniRef50_C2D1B3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Lactobacillus RepID=C2D1B3_LACBR Length = 327 Score = 386 bits (992), Expect = e-106, Method: Composition-based stats. Identities = 109/319 (34%), Positives = 171/319 (53%), Gaps = 10/319 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K ++ + + + + L G IE D L E RDA + + H+ E V+ Sbjct: 16 KKVVVPKSLSEDGKKFLTDRGIDIIEVDGNFTDG--LLEHGRDADGMIIFL-DHVGEAVL 72 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 + L I +G + +DLDA+A+ G+ V N P +N +VAE + E+ L + V +A Sbjct: 73 SQMPNLKIIARHGVGYDSIDLDASAQHGVWVTNTPNANAATVAETTLAEIFDLSKNVTKA 132 Query: 131 NAKAHRGVWNKL-AAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 +++ +G + A F+ GK LGIIGYGHIG Q+ A +L M + Y+ K Sbjct: 133 SSEMRKGNYTYALAHRGFDLAGKTLGIIGYGHIGQQVAKKASALDMPILIYNRSKKESPY 192 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 + L LL +D+V+LH+ NP+T +++G +++ MK S+LIN RG ++D AL Sbjct: 193 G--KFVDLDTLLKTADIVTLHLASNPATHHIIGKDQLAEMKRSSVLINLGRGGLIDTSAL 250 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 +AL + +AGAA+DVF EP P S L +FDNVLLTPHIG ST E+ + ++ A Sbjct: 251 INALKTHQIAGAALDVFEEEPL----PLDSDLFQFDNVLLTPHIGSSTVESFSRMAVDAA 306 Query: 310 GKLIKYSDNGSTLSAVNFP 328 ++++ + VN P Sbjct: 307 SEVVRVLNGEKPQWPVNEP 325 >UniRef50_A6C2G1 Phosphoglycerate dehydrogenase (SerA) n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C2G1_9PLAN Length = 316 Score = 386 bits (992), Expect = e-105, Method: Composition-based stats. Identities = 106/316 (33%), Positives = 155/316 (49%), Gaps = 10/316 (3%) Query: 13 FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINA 72 L+ E + ++ L + + + + LK+ I++ + +R++T + ++I+A Sbjct: 4 VLVTENIQGVSMNRLIQEHDVEFDAYLWQ-NIDLLKQKIQNTRALIVRNQTKVDRELIDA 62 Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA 132 A +L I G + VD + A ++GI V P +N+ SVAEL IG +L L+R +PEA Sbjct: 63 APELKIIARAGAGLDNVDTEYAHEKGIVVCFTPDANSLSVAELTIGLMLALMRKIPEARQ 122 Query: 133 KAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN-- 190 G WN+L E GK G+IG G IG+ A++ GM + D K Sbjct: 123 DTLTGGWNRLKFTGTELYGKSFGLIGLGRIGSFTATRAKAFGMNILAADPFLKADAPQLK 182 Query: 191 --ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + L DLL SDVVS H P P T+ M+ + MKP + IN SRG VVD Sbjct: 183 KLNATLLSLDDLLAESDVVSCHSPLTPDTRKMLTYQHFRKMKPDAFFINTSRGEVVDERG 242 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L AL LAGAA+DV TEP SPL + +NV+LTPHI T EAQ+ + V Sbjct: 243 LTQALLEHKLAGAALDVRETEPPKQ-----SPLNQMENVILTPHIAAFTVEAQDRVVDSV 297 Query: 309 AGKLIKYSDNGSTLSA 324 + ++ Sbjct: 298 CEDVRLVLSGKKAINV 313 >UniRef50_B7CA05 Putative uncharacterized protein n=1 Tax=Eubacterium biforme DSM 3989 RepID=B7CA05_9FIRM Length = 382 Score = 386 bits (992), Expect = e-105, Method: Composition-based stats. Identities = 110/411 (26%), Positives = 175/411 (42%), Gaps = 50/411 (12%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K L + Q L+ D ++ E++ D I +RS I Sbjct: 2 PKIKLYNNIAQIGLDQF--------------TPDYEVNENMEDEDAILVRSANLHD---I 44 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 L AI G N +D+D K+GI VFN P +N+ +V E V +LL R + Sbjct: 45 EYGNNLKAIARAGAGVNNIDIDTCTKKGIAVFNTPGANSNAVKEFVFAGMLLASRDIYHG 104 Query: 131 NAKA----------HRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 K E GK LG+IG G IG Q+ LA GM VY Y Sbjct: 105 IEWIQTQKENENIAKDVEKQKKKYAGHELTGKSLGVIGCGAIGIQVANLALRFGMKVYGY 164 Query: 181 DIENKLPLG-----NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLL 235 D + V ++ DL D +++HVP N TKN + MK G L Sbjct: 165 DPYMSVDAAWNLSRYVNHVTNIDDLYRQCDFITIHVPLNDGTKNFINKDSFDKMKDGVKL 224 Query: 236 INASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGG 295 +N +RG +VD AL +AL +A D + + + D V+ PH+G Sbjct: 225 LNFARGGLVDEDALLEALDENKVASYVTD-----------FPSQKVLQSDKVIAIPHLGA 273 Query: 296 STQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALN 355 ST+E++EN ++ A +L+ Y G+ ++VN P + ++ R+ IH+N+P +++ + Sbjct: 274 STEESEENCAVKAARELMDYLTYGNISNSVNLPNAKMDMNSPFRITCIHDNKPKMISQIT 333 Query: 356 KIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRA 406 I + NI ++ + Y +ID++ D+ ++ I G I+ Sbjct: 334 DILKD--ANIENLMNKSKKDIAYTIIDLDTKVDITP-----IEKINGMIKV 377 >UniRef50_Q6A895 D-3-phosphoglycerate dehydrogenase n=4 Tax=Actinomycetales RepID=Q6A895_PROAC Length = 417 Score = 385 bits (991), Expect = e-105, Method: Composition-based stats. Identities = 198/400 (49%), Positives = 276/400 (69%), Gaps = 5/400 (1%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K LL+E +H +A+ +L+ AGY +E ALD++ L ++ +G+RSRT +T V+ Sbjct: 22 MKALLLENIHDEAVRTLKKAGYE-VERVSEALDEDDLISALDGVDLLGIRSRTRVTRRVV 80 Query: 71 NAA-EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 A +KL A+G FCIGTNQ+DLDA A+ G+P FNAP+SNTRSV ELV+ E++ L R + + Sbjct: 81 EACGDKLHAVGAFCIGTNQMDLDALAEAGVPAFNAPYSNTRSVVELVMAEIIALARRLGD 140 Query: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 N + H GVW K A GS E RG++LGIIGYG+IG QL ++AE++GM V+FYDI + LP+G Sbjct: 141 RNTQMHNGVWRKSAIGSHEIRGRRLGIIGYGNIGQQLSVVAEAMGMQVFFYDIADVLPMG 200 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 NA + + +LL + VSLH+ PS +++G +E ++M+P SL +N SRG VVDI AL Sbjct: 201 NAHKCDSMEELLGSVETVSLHIDGRPSNTDLIGDREFAMMRPRSLFLNLSRGKVVDINAL 260 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 D L + H+AGA +DV+P EPA+ +PF SPL E DNV+LTPHIGGSTQEAQ +IG VA Sbjct: 261 VDNLRTGHIAGAGVDVYPEEPASGKEPFISPLREMDNVILTPHIGGSTQEAQVDIGRYVA 320 Query: 310 GKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQY 369 GKLI Y DNG+T +VN PE++ G R+ H+H N PGV+ LN++ A+QG N+ Q Sbjct: 321 GKLIDYVDNGATGMSVNIPEITPSPRTGARIGHLHRNVPGVMATLNRLVADQGGNVTYQA 380 Query: 370 LQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 L T ++GY ++DI + L + + GTIRAR+L Sbjct: 381 LATKGELGYCILDIA---ETDSGLLANVTVLEGTIRARIL 417 >UniRef50_Q1J0H2 D-3-phosphoglycerate dehydrogenase n=8 Tax=Deinococci RepID=Q1J0H2_DEIGD Length = 542 Score = 385 bits (990), Expect = e-105, Method: Composition-based stats. Identities = 106/360 (29%), Positives = 173/360 (48%), Gaps = 15/360 (4%) Query: 6 LEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 ++ L+ + ++ L G+ ++G L E+ + + RSRT + Sbjct: 12 ARTAPLRVLICDEMNPGD---LHHEGFEI--DYEGNLPREETLRRLPGYDALITRSRTKV 66 Query: 66 TEDVINAA-EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 +++ AA ++L IG +G + +DL+A ++RGI V NAP SN S AEL I LL Sbjct: 67 DRELLEAAGDRLKVIGRGGVGVDNIDLEACSRRGILVLNAPESNNVSAAELAIMHLLAAA 126 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 RG+ ++ K G W++ E + K LGI+G G IG+ + A+ L + V YD Sbjct: 127 RGLTRSDRKTRAGEWDRK-FLGVELKDKTLGIVGLGRIGSIVADRAQGLRLKVVAYDPYV 185 Query: 185 KL---PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 + L +LL D +++H P T M+GA+E++L+K G++++NA+RG Sbjct: 186 PENKFERLGVERAATLDELLTRVDFLTVHTPLTEETNGMIGARELALLKRGAIVVNAARG 245 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 +V AL +AL S HL A +DVF EP P N+ +T H+G +T EAQ Sbjct: 246 GIVQEAALVEALQSGHLFAAGVDVFVEEPPAPD----HPFLSAPNLGITAHLGANTFEAQ 301 Query: 302 ENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPG-VLTALNKIFAE 360 E +G E+ G+++ + AVN P + + G +L L + Sbjct: 302 ERVGAEIVGRVLAALHGDVSKGAVNAPALDAKTLELLGGYLDLGEKLGRILAQLLPGAHD 361 >UniRef50_A9A5A9 Glyoxylate reductase n=2 Tax=Thaumarchaeota RepID=A9A5A9_NITMS Length = 322 Score = 385 bits (990), Expect = e-105, Method: Composition-based stats. Identities = 90/323 (27%), Positives = 140/323 (43%), Gaps = 11/323 (3%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 + K L +H AL+ L+ + K + +L+ I+D + + ++ Sbjct: 2 RKKVFLTRTLHDFALKELKKKYQIEVHKGKIPVPQSKLRSKIKDVDGLICFPYDIINKET 61 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I+ AE L I + +G + +D A + I V P T + A+L LL LR V E Sbjct: 62 IDLAENLKVISTYSVGFDHIDTKYAKGKKIRVGYTPEVLTDATADLAFSLLLDSLRRVSE 121 Query: 130 ANAKAHRGVWN----KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI--- 182 + G W + +GK +GI+G G IG L A++ M + +++ Sbjct: 122 GDRIIRDGKWKMIYGAHDYVGVDLQGKTIGILGLGRIGQTLAKRAKAFDMDIIYHNRNRL 181 Query: 183 ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 + L++ SDV+S+HVP T M K MK + LIN SRG Sbjct: 182 SKTKERTLDAKYVSFERLISQSDVISIHVPHTKETDKMFNMKIFKKMKNTAFLINTSRGK 241 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 VV+ L AL K +AGA +DVF EP + PL + NV+L PHIG ST+E + Sbjct: 242 VVNEKDLVTALKKKIIAGAGLDVFEQEPISK----NHPLTKLQNVVLAPHIGSSTKETRA 297 Query: 303 NIGLEVAGKLIKYSDNGSTLSAV 325 + L + + +V Sbjct: 298 KMAEITVRNLNLGMNGKKPIYSV 320 >UniRef50_B1KZ88 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=29 Tax=Clostridiaceae RepID=B1KZ88_CLOBM Length = 314 Score = 385 bits (990), Expect = e-105, Method: Composition-based stats. Identities = 107/309 (34%), Positives = 167/309 (54%), Gaps = 10/309 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 IK L+ +G+ + AL L G+ ++ H + E+LK+ I+D I +RS T + +++I Sbjct: 2 IKILVSDGMEKNALNKLNEQGFVVLDKH---FEKEELKDKIKDFDAIIIRSATKVDKEII 58 Query: 71 NAA--EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 +A L + +G + VDL+ A ++G+ VFN P +++ SVAEL +G +L + R + Sbjct: 59 DAGIKGNLKLVVRAGVGLDNVDLEYAKEKGVKVFNTPKASSVSVAELTLGHMLCISRFIN 118 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL 188 AN +G W K E GK LG+IG+G I ++ A +LGM V +YDI K Sbjct: 119 TANVTMLQGKWEKKKYKGTEIYGKTLGLIGFGRIAREVAKRANALGMNVIYYDIAGKCEE 178 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + L LLN SD +S+H+P N ++ +E + MK G ++N +RG V++ A Sbjct: 179 YEEFKCCTLDYLLNNSDFISVHIPFNKDRGALLKEEEFNKMKDGVYIVNCARGGVIEEEA 238 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L AL + + AA+DVF EP L + V +TPHIG ST+EAQ IG E+ Sbjct: 239 LLKALNNGKVTAAALDVFENEPEPKK-----ELINHERVSITPHIGASTKEAQMRIGEEI 293 Query: 309 AGKLIKYSD 317 L + + Sbjct: 294 VDILDNFFN 302 >UniRef50_C9MSC4 Glycerate dehydrogenase n=3 Tax=Prevotella RepID=C9MSC4_9BACT Length = 316 Score = 384 bits (988), Expect = e-105, Method: Composition-based stats. Identities = 96/325 (29%), Positives = 154/325 (47%), Gaps = 19/325 (5%) Query: 11 IKFLLVE----GVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLT 66 +K ++++ + E ++ I E + E +DA I + ++ ++T Sbjct: 1 MKIVILDCHAVNPGDLSWEPIKQLADCTIYERTR---QEDVVERAKDADGILI-NKVNIT 56 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 E+V+ KL IG G N +D+ AA RG+ V N P +T SVA+ V LL Sbjct: 57 EEVLQQLPKLKYIGELATGYNNIDIAAARARGVVVCNIPAYSTDSVAQHVFALLLNAATR 116 Query: 127 VPEANAKAHRGVWNKLAAGSF------EARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 V RG W K + E GK LGI+G GHIG ++ +A ++GM + Y Sbjct: 117 VDHYAEAVRRGEWCKQQDFCYWDTPLIELAGKTLGIVGLGHIGQKVAQIAHAMGMDISAY 176 Query: 181 DIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 +N L + L L + SDV++LH P +M+ A+ + M+PG++LIN R Sbjct: 177 TSKNSTDLPECIRKTTLEGLFSTSDVITLHCPLTAENAHMINAERLQKMRPGTILINTGR 236 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G ++D A+ DAL S HL DV EP + PL + N +TPH+ +T+EA Sbjct: 237 GGLIDEQAVADALESGHLKAYCADVMTDEPPRKDN----PLLQQPNAYITPHVAWATREA 292 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAV 325 +E + + K+ + + + V Sbjct: 293 RERLMAIAVENIRKFIEG-TPQNCV 316 >UniRef50_D1YY17 Glycerate dehydrogenase n=1 Tax=Methanocella paludicola SANAE RepID=D1YY17_METPS Length = 326 Score = 384 bits (987), Expect = e-105, Method: Composition-based stats. Identities = 106/321 (33%), Positives = 155/321 (48%), Gaps = 13/321 (4%) Query: 11 IKFLLVEGVH--QKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 +K ++ E ++ + L A G DE I+DA I + R + + Sbjct: 1 MKIVISEPIYLTDEYRRRLEALGDLRAY-DSVPTSDEDFVSRIKDAE-IVIAGRYGFSGE 58 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 I A L I + G + VDL AA RG+ V N +VAE L LLR V Sbjct: 59 SIRRAPGLKMIALWQTGYDNVDLAAATARGVVVSNVHNYAFDTVAEFAFALALNLLRKVD 118 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVY---FYDIENK 185 +A+ RG+++ E GK LG+IG G IG ++ +A M V + + + Sbjct: 119 KADLNLRRGLFDWRRYVGEELMGKTLGVIGLGSIGRRVVQIAHGFNMSVLSVTAH-PDPE 177 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 + L LL SDVVSLHVP P T++M+GA +++ MKP ++LIN +RG +VD Sbjct: 178 RARALGVKFVSLDTLLAESDVVSLHVPLTPETEHMIGAAQLARMKPTAILINTARGKIVD 237 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL +AL K +AGA +DVF TEP P SPL + DNV+LTPHI ++E+ + Sbjct: 238 EKALVEALREKRIAGAGLDVFETEPL----PMDSPLLKLDNVVLTPHIAFLSKESIDECT 293 Query: 306 LEVAGKLIKYSDNGSTLSAVN 326 + + + VN Sbjct: 294 RVTMENVEMFVKGR-PQNVVN 313 >UniRef50_C0CRA6 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=C0CRA6_9FIRM Length = 321 Score = 383 bits (985), Expect = e-105, Method: Composition-based stats. Identities = 99/323 (30%), Positives = 147/323 (45%), Gaps = 16/323 (4%) Query: 11 IKFLLV-EGVHQ----KALESLRAAGYTNIEFHK-GALDDEQLKESIRDAHFIGLRSRTH 64 +K L+ + KALE LR + K L +E+L ++ Sbjct: 3 MKILVTPTSLQPGRKSKALERLRDFSEELVFNDKSRPLTEEELIPLLKGCQGYL-AGLDF 61 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 +TE V+ AE L I + G +++D+ AA++ G+ V N P N ++V EL G LL + Sbjct: 62 ITERVLREAEDLKVISRYGTGYDRIDMAAASQYGVTVTNTPGVNAQAVGELAFGLLLSVA 121 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 R + + G W + E +GK LGI+G G IG + A+ GM V D Sbjct: 122 RQISYLDRTTRSGEWVRAE--GVELKGKTLGILGLGAIGKVVARCAKGFGMRVAASDPFI 179 Query: 185 KLP--LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 + + + DLL+ +D VSLH+P N T +++G + ++ MK G +LIN SRG Sbjct: 180 DREYCREHGIEAMDMEDLLSFADAVSLHLPLNKETTHLIGKEALARMKDGVILINTSRGG 239 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 ++D A L S + G +D F EP P S L EF NV+ TPH G T+EA Sbjct: 240 IIDEEAAYCGLKSGKIGGLGLDAFENEP-----PKGSSLFEFSNVVATPHTGAHTKEAAS 294 Query: 303 NIGLEVAGKLIKYSDNGSTLSAV 325 + LI V Sbjct: 295 MMAERAVDNLISVLQGERCPYIV 317 >UniRef50_A7NS02 Glyoxylate reductase n=8 Tax=Bacteria RepID=A7NS02_ROSCS Length = 341 Score = 382 bits (983), Expect = e-104, Method: Composition-based stats. Identities = 95/330 (28%), Positives = 146/330 (44%), Gaps = 17/330 (5%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKG-ALDDEQLKESIRDAHFIGLRSRTHLTED 68 + + L + Q A++ + AA T + + E L ++ + I + + Sbjct: 2 RPRVYLTRRLPQAAVDIVTAACETTFWDDEALPVPRETLLRAVAEVDGILTLLTDRVDVE 61 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 +++AA +L + +G + VDL A RG+ + N P T + A+LV +L R V Sbjct: 62 LLDAAPRLKVVANMAVGYDNVDLPALTARGVLLTNTPDVLTETTADLVWALILAASRRVV 121 Query: 129 EANAKAHRGVWNKLAAG---SFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 E + G W+ + + G LGI+G G IG + A GM + +++ Sbjct: 122 EGHRLIAAGGWSTWSPMFMVGQDVHGATLGIVGAGRIGAAVARRAVGFGMPILYHNRHPS 181 Query: 186 LPLGNATQVQH---------LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLI 236 L + L DLL SDVV + VP P T+ M GA+E +LMKP S+ + Sbjct: 182 PALEAQIRATPGAAIRYVPNLDDLLTESDVVVVMVPLTPETRGMFGAREFALMKPTSVFV 241 Query: 237 NASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGS 296 NASRG V+ L DAL A +DVF EP PL NV+LTPHIG + Sbjct: 242 NASRGPVIREAELIDALQRGRPWAAGLDVFEREPIGAD----HPLLTLPNVVLTPHIGSA 297 Query: 297 TQEAQENIGLEVAGKLIKYSDNGSTLSAVN 326 T + + + A L+ + VN Sbjct: 298 TVATRTRMAVVAATNLVAALTGQPVPNPVN 327 >UniRef50_O32264 Probable 2-ketogluconate reductase n=7 Tax=Bacillales RepID=TKRA_BACSU Length = 325 Score = 382 bits (983), Expect = e-104, Method: Composition-based stats. Identities = 82/322 (25%), Positives = 142/322 (44%), Gaps = 13/322 (4%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGL--RSRTHLTE 67 K + + + ++ + + L + L E +++A + S + Sbjct: 3 KPFVFITKPIPEEIEAFIGEHCRYEVWQEDT-LPSDVLFEKLKEAEGLLTSGTSGPSINR 61 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 +++ A KL + +G + D++A +RG+ + P++ +VA+L +L R V Sbjct: 62 ELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTLDDTVADLAFSLILSSARRV 121 Query: 128 PEANAKAHRGVW---NKLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIE 183 E + G W + A + + LGIIG G IG Q A+ M V +++ Sbjct: 122 AELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIGEQAARRAKFGFDMEVLYHNRH 181 Query: 184 NKLPLGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 K + + L LL SD + L P T +M+G +E LMK ++ +N SRG Sbjct: 182 RKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETYHMIGEREFKLMKNSAIFVNISRG 241 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 VD AL AL + GA +DV+ EP T + PL + DNV L PHIG +T + + Sbjct: 242 KTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDN----PLLQLDNVTLLPHIGSATAKVR 297 Query: 302 ENIGLEVAGKLIKYSDNGSTLS 323 N+ + A ++ + + Sbjct: 298 FNMCKQAAENMLAAIQGQTPKN 319 >UniRef50_Q46AE6 Glycerate dehydrogenase n=2 Tax=Methanosarcina RepID=Q46AE6_METBF Length = 323 Score = 382 bits (981), Expect = e-104, Method: Composition-based stats. Identities = 102/325 (31%), Positives = 161/325 (49%), Gaps = 14/325 (4%) Query: 11 IKFLLVEGV--HQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 +K ++ + + ++ + L A G + F E+ +RDA + + R + Sbjct: 1 MKIVVSDSIFLPEEYRKKLDALGDLKV-FESMPSSIEEFISRVRDADIVLV-GRYGFSGK 58 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 NA+ L + + G + +DL AA ++G+ V N P SVAE+V L LLR V Sbjct: 59 AFNASRNLQMLSVWQTGYDHIDLKAATEKGVIVSNVPDYAFDSVAEMVFALALNLLRKVH 118 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVY---FYDIENK 185 A+ + G ++ + GK +G+IG G IG+++ +A M V + + Sbjct: 119 VADIRLREGNFDWRHYFGSQIMGKTMGVIGTGSIGSRVIQIAHGFNMNVISVTGH-PSEE 177 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 + L LL +D+V+LHVP PST+ M+GAKE++ MK ++LIN +RG VVD Sbjct: 178 KARSLGVKFVDLDTLLAEADIVTLHVPLTPSTEKMIGAKELAKMKKSAILINTARGKVVD 237 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL +AL K + GA +DVF EP P PL +NV+LTPHI T+E+ E Sbjct: 238 EAALIEALKEKKIRGAGLDVFEKEPL----PANDPLKALENVVLTPHIAFLTEESLEECT 293 Query: 306 LEVAGKLIKYSDNGSTLSAVNFPEV 330 + ++ + + VN PEV Sbjct: 294 YVCVQNVERFIEGK-PQNIVN-PEV 316 >UniRef50_A9KPU0 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Clostridium phytofermentans ISDg RepID=A9KPU0_CLOPH Length = 316 Score = 380 bits (978), Expect = e-104, Method: Composition-based stats. Identities = 98/322 (30%), Positives = 156/322 (48%), Gaps = 12/322 (3%) Query: 11 IK--FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 +K L+ + V + L+ GY ++ E + +I D + LR T++ Sbjct: 1 MKQIILIPQDVDESGKNYLQEKGYELRILQDSSI--ENICNNIGDCSGLLLR-TVPCTKE 57 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 V +AA L IG +G + +D+ A +GI V P +N SVAE I LL + + Sbjct: 58 VFDAAPHLKVIGRHGVGYDNIDIAEATAQGIKVCYTPLANANSVAEHTIMLLLACAKNIV 117 Query: 129 EANAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDI--EN 184 A+ + +G + + + GK LGIIG+G IG + A LGM + Y E Sbjct: 118 IADKELRQGNYEIRNQMPGIDVFGKTLGIIGFGRIGKSVAKKAALGLGMKILAYGRGLEI 177 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 K T ++ + +L+ SD +SLH+P + + M + ++SLMKP ++LIN +RG +V Sbjct: 178 KEVPDYVTIIKEVDELIRQSDFISLHMPYSKEMQGFMDSTKLSLMKPEAVLINTARGGIV 237 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 + L AL + +AGA +DVF EP S L + DNV++TPH T+EA + Sbjct: 238 NEDDLYHALINHKIAGAGLDVFIDEPFKE---TLSNLFQLDNVVVTPHSAALTKEAMARM 294 Query: 305 GLEVAGKLIKYSDNGSTLSAVN 326 L+ A + + VN Sbjct: 295 SLDAAIGIDEVLSGKKPSWPVN 316 >UniRef50_UPI0001BC4ADC hypothetical protein FulcA4_06865 n=1 Tax=Fusobacterium ulcerans ATCC 49185 RepID=UPI0001BC4ADC Length = 319 Score = 379 bits (974), Expect = e-103, Method: Composition-based stats. Identities = 103/321 (32%), Positives = 160/321 (49%), Gaps = 10/321 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K L+ + V ++ +E L++ G+ H +E L + + D I LR TE V+ Sbjct: 3 HKVLIPQAVAKEGVELLKSYGFEI--KHGSGASEEDLIKDVADCDAILLR-TAPCTEAVL 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A + L + G N VDL+AAAK GI NAP S T +VAE V+G +L + + + Sbjct: 60 KAGKNLKIVARHGAGYNNVDLEAAAKLGIWATNAPDSTTNTVAEFVLGAILAVSKRIFLM 119 Query: 131 NAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILA-ESLGMYVYFYDIENKLPL 188 N K G + K + GKKLG++G+G IG ++ A LGM + YD Sbjct: 120 NKKIKEGDFFFKNNHKGMDLTGKKLGVVGFGRIGRKVAYKAFYGLGMEILAYDPFLTKEN 179 Query: 189 -GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + + + SD++SLH+P +G KE + MK + IN +RG VV+ Sbjct: 180 CPDYVTICDWETIFKESDIISLHMPLIKENIGCVGKKEFTNMKKSAHFINCARGEVVNEK 239 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 L +AL ++ +AGA +DVF EP + PL DNV++TPH+ +T+E + ++ Sbjct: 240 ELIEALKTEEIAGAFLDVFEQEPPLEDN----PLLSMDNVIVTPHMASNTEECMILMAVQ 295 Query: 308 VAGKLIKYSDNGSTLSAVNFP 328 A +++K N VN P Sbjct: 296 AASEIVKVLSNEKPCWPVNNP 316 >UniRef50_B0NG91 Putative uncharacterized protein n=1 Tax=Clostridium scindens ATCC 35704 RepID=B0NG91_EUBSP Length = 319 Score = 375 bits (965), Expect = e-102, Method: Composition-based stats. Identities = 98/324 (30%), Positives = 153/324 (47%), Gaps = 15/324 (4%) Query: 10 KIKFLLVE----GVHQKALESLRAAGYTNIEFHKGALD-DEQLKESIRDAHFIGLRSRTH 64 K K ++ +AL L + G DEQ+KE I A + Sbjct: 3 KYKVIVTARSFAKADDQALRLLEEHDCDVVRLVAGVATFDEQIKEEIAAADAVI-AGLDE 61 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 ++++I+ A KL I + +G ++VD++AA ++GI V P +N SVA+L + +L Sbjct: 62 YSKELIDLAGKLKVISRYGVGYDKVDVEAADRKGILVTITPGANGDSVADLAVTLMLDAA 121 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 R V +A G + E K LG+IG G IG + + M + YDI Sbjct: 122 RNVAAMDAAMK-GR-AQARPQGVEMWQKTLGVIGTGRIGQGVARRCKGFDMKILCYDIYE 179 Query: 185 KLPL--GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 + LS LL SD +++H P P TK+M+GA+E +MK ++++N +RG Sbjct: 180 NEAFKKECNAKYVDLSTLLRESDFITIHSPLTPETKDMIGAREFDMMKNDAVIVNTARGG 239 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 +++ AL +AL S + GA +D EP P+ SPL N +LTPH G +T+EA Sbjct: 240 IINEEALYEALKSGSIRGAGLDATVDEP-----PYDSPLMTLPNCILTPHAGAATKEASS 294 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVN 326 + L A ++ G VN Sbjct: 295 KMSLMAAQNVVDVLTTGDCKYKVN 318 >UniRef50_D1C3Y3 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C3Y3_SPHTD Length = 316 Score = 375 bits (963), Expect = e-102, Method: Composition-based stats. Identities = 96/316 (30%), Positives = 155/316 (49%), Gaps = 10/316 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + L+ + + AL+ LR ++ +L ++L + + + +R T +T +VI Sbjct: 7 PRILVCDPIDDGALDLLRRHARVDVR---TSLAPDELVDIVGGYDGLVVRGTTQITSEVI 63 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA L I + +D+DAA +RGI V ++P + T +VAE+ IG +L +LR +P A Sbjct: 64 EAATALRGIARVGFAVDNIDIDAATERGIVVVHSPGARTYAVAEMTIGLILAVLRHIPAA 123 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + G W + A + RG +G+IGYG IG ++ LA + G V Y + Sbjct: 124 DRSVKAGRWERRAFRGRQLRGATVGVIGYGRIGREVARLAHAFGATVKAYTQTPRP--LE 181 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 + LL SD+++LH +T+ ++ + I M+ G +++N + G ++D AL Sbjct: 182 HAKQVDFQALLASSDIITLHATLTSATRQLINREAIEQMRDGVVIVNTASGGLIDEAALL 241 Query: 251 DALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAG 310 +AL +AGA +DVF EP P L E V+ TP IGGSTQEA + Sbjct: 242 EALDRGKVAGAGLDVFADEP-----PSLRALVEHPRVVTTPRIGGSTQEADRAVSELALQ 296 Query: 311 KLIKYSDNGSTLSAVN 326 L+ AVN Sbjct: 297 SLLAVLRGEQPAVAVN 312 >UniRef50_A5W066 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=2 Tax=Pseudomonas RepID=A5W066_PSEP1 Length = 324 Score = 373 bits (960), Expect = e-102, Method: Composition-based stats. Identities = 104/322 (32%), Positives = 160/322 (49%), Gaps = 11/322 (3%) Query: 13 FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINA 72 + +H+ L L G + + A+ E+++ + + LR H++ ++I A Sbjct: 4 IYVTSPIHETILSRLSDLGEVRLGYGPNAVAYEEIRNQV---DAVFLRGG-HISAEMIAA 59 Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA 132 + KL + G + VD AAA G+ V N P +N RSV E V LL L R +P A+ Sbjct: 60 SPKLRIVARHGAGYDNVDYKAAADHGVWVTNTPGANQRSVIEHVFALLLSLCRKLPLASE 119 Query: 133 KAHRGVW--NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + VW ++L+ E G+ LG++G+G+IG+ + +AE+ GM V F D + Sbjct: 120 QTRNRVWAEDRLSLTGIELEGRTLGLVGFGNIGSSVAPVAEAFGMKVIFTDPAIDPSSDS 179 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 + LL+ +DVVSLHVP +T+N++G E + MK G++LIN SRG VVD AL Sbjct: 180 --RWVDFDTLLSTADVVSLHVPLLETTRNLIGVPEFAKMKDGAMLINTSRGGVVDEQALV 237 Query: 251 DALASKHLAGAAIDVFPTEPATNSDPFTS---PLCEFDNVLLTPHIGGSTQEAQENIGLE 307 DAL S LAGA DV E PF + N+++T H+ G T E+ +G+ Sbjct: 238 DALKSGKLAGAGADVLAAENIDMIKPFDHDTPDIANTPNLIVTAHVAGQTDESLLRVGMS 297 Query: 308 VAGKLIKYSDNGSTLSAVNFPE 329 + + VN P Sbjct: 298 ALEAIAAVLKGQAPAHPVNQPA 319 >UniRef50_C2HJZ3 Possible glyoxylate reductase n=2 Tax=Finegoldia magna RepID=C2HJZ3_PEPMA Length = 313 Score = 373 bits (959), Expect = e-102, Method: Composition-based stats. Identities = 96/320 (30%), Positives = 160/320 (50%), Gaps = 11/320 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ + ++ ++ + L E+LK I+D + + ++I Sbjct: 1 MKVLITNRIPEEIIKKYEENFEVDYHDSLDFLSKEELKTRIKDVEGLVCPLSEKIDSEII 60 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPF-SNTRSVAELVIGELLLLLRGVPE 129 +AA+ L I + G + VD+D A ++GI V NAP ++T+S AEL G ++ LLR + + Sbjct: 61 DAAKNLKIIANYGAGFDNVDIDYAKEKGIIVTNAPASASTKSTAELTFGLMIDLLRNITK 120 Query: 130 ANAKAHRG---VWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL 186 N+ + W + GK LGIIG G IGT++ A++ M V FY+ K Sbjct: 121 MNSDCYDNSFEGWKPVYGLGETLEGKTLGIIGLGRIGTEVMRKAKAFDMNVIFYNRSKKE 180 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + + L+ LL SDV++LH + +++ AK S MK + LINASRG V+ Sbjct: 181 --VDGAKQVDLNYLLENSDVITLHTAYSEKLHHLIDAKAFSKMKKSAYLINASRGKVISE 238 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 L +AL +AG A+DV+ EP + D L N+LL PH+G +T+ A+ +G Sbjct: 239 QDLINALNDGEIAGCALDVYEFEPKISED-----LRNAKNILLAPHLGNATKLARVQMGE 293 Query: 307 EVAGKLIKYSDNGSTLSAVN 326 ++++ + + VN Sbjct: 294 FTFDNIMQFKNGEIPKNKVN 313 >UniRef50_Q5WLJ2 D-3-phosphoglycerate dehydrogenase n=7 Tax=Bacteria RepID=Q5WLJ2_BACSK Length = 316 Score = 373 bits (958), Expect = e-102, Method: Composition-based stats. Identities = 94/325 (28%), Positives = 143/325 (44%), Gaps = 16/325 (4%) Query: 11 IKFLLVEGV----HQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLT 66 +K + + + L+ G + + R A + Sbjct: 1 MKVICTSPSFAKHSNEPIIRLQQEGIELVRV-PPDISQSAFVLEARGAQAAIVAFNEIHD 59 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 V+ L I +G + +D+DAA K G+ V N P +N +VA+ LL L R Sbjct: 60 A-VLAQLPDLKIIAKHGVGVDNIDVDAAKKHGVTVTNVPNANKHAVADFAFSLLLSLARQ 118 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--N 184 +P N K +G W + + + LGIIG G IG ++ A M V YD Sbjct: 119 IPTGNEKTKKGKWP--SLFGADVYQQTLGIIGLGAIGKEVARRASGFSMTVLAYDPYIDR 176 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 N + L LL SD V++H+P P T++++G +E+ LMK + L+NASRG +V Sbjct: 177 TYARKNGIEAVSLDALLQQSDFVTIHIPLLPETRHLIGERELQLMKKSAYLVNASRGGIV 236 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL +AL ++ LAGAA+DVF EP SPL D+ + PH+ G T A + Sbjct: 237 DETALYEALQTQQLAGAALDVFEEEPL-----HMSPLFSLDSFIAMPHVAGYTPGAINTL 291 Query: 305 GLEVAGKLIKYSDN-GSTLSAVNFP 328 ++I G + V+ P Sbjct: 292 SHTCVDQIIAVLKGKGDLIHVVSGP 316 >UniRef50_Q0W672 Glycerate dehydrogenase n=2 Tax=Archaea RepID=Q0W672_UNCMA Length = 319 Score = 372 bits (957), Expect = e-101, Method: Composition-based stats. Identities = 101/320 (31%), Positives = 149/320 (46%), Gaps = 11/320 (3%) Query: 13 FLLVEGVHQKAL--ESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 ++ + V + L G + L E+ I +A + S L Sbjct: 4 IVIADAVSKHELYEHHFGKIGDLKVY-RGPPLSMEEYLCRIAEADVAVV-SHFKLPARSF 61 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +++ L + G + VDLDAA +G+ V NAP + +VAE V LL +R + EA Sbjct: 62 DSST-LKLVALTRTGYDDVDLDAATLKGVAVANAPGYSNEAVAEHVFAMLLSFIRRISEA 120 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + ++ A E RGK +GIIG G IG ++ +A GM V YD+ + Sbjct: 121 DFWIREEKFDCTAFEGRELRGKTMGIIGTGQIGLRVAEIARCFGMDVIAYDVRRNPAVAE 180 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 + L L SD +++H+P T+ ++ + LMKPG+++IN +RG VVD AL Sbjct: 181 KLRYVGLDRLCAESDFITVHLPLTSDTRGLIDEESFRLMKPGAVIINTARGPVVDQAALL 240 Query: 251 DALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAG 310 AL +AGA +DVF EP P SPL N LLTPHI +T+EA+E A Sbjct: 241 RALDEGRIAGACLDVFDQEPL----PPDSPLLAMSNTLLTPHIAYNTREAKEQSIAIAAE 296 Query: 311 KLIKYSDNGSTLSAVNFPEV 330 + Y + VN P V Sbjct: 297 NVALYLSGK-PRNIVN-PAV 314 >UniRef50_A6Q7Q2 D-3-phosphoglycerate dehydrogenase n=49 Tax=Epsilonproteobacteria RepID=A6Q7Q2_SULNB Length = 529 Score = 372 bits (957), Expect = e-101, Method: Composition-based stats. Identities = 108/365 (29%), Positives = 176/365 (48%), Gaps = 10/365 (2%) Query: 8 KDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 K ++ + +HQ L+ L + D+ + E I A RS T + Sbjct: 1 MSKKTIVVCDHIHQSGLDILANDSEIKLINAADEPKDKLIAEIIPLADVAITRSSTDVDA 60 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 + +A+K+ AI +G + VD+ ++K+GI V N P +NT + EL + +L +R Sbjct: 61 AFLESAKKITAIVRAGVGVDNVDIPGSSKQGIVVMNVPTANTIAAVELTLAHMLSCVRQF 120 Query: 128 PEANAKAH-RGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--N 184 P A+ VW + E + KKLGIIG+G+IG+++G A++ M V YD Sbjct: 121 PYAHNNLKLDRVWRRQDWYGTELKDKKLGIIGFGNIGSRVGKRAKAFEMDVLAYDPYIDP 180 Query: 185 KLPLGNATQVQ-HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 + D+L D++++H P+ T M+ EI+ MK G +LIN +RG + Sbjct: 181 SKATDLDIGYTKNFEDILA-CDIITIHTPKTEETIGMINKDEIAKMKDGVILINCARGGL 239 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 + AL + L S +A A IDVF EPAT PL + DNV +TPH+G +T+E+Q N Sbjct: 240 YNEEALLEGLKSGKIAMAGIDVFNKEPAT-----DHPLLDLDNVTVTPHLGANTKESQRN 294 Query: 304 IGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGV 363 I ++ A I + + +A+N P L R + G L++ A + + Sbjct: 295 IAIQAAENAIAAAKGIAYPNALNLPIKENELPDFVRPYLELIQKMGHLSSQVTKSAVKSI 354 Query: 364 NIAAQ 368 + A+ Sbjct: 355 KVTAK 359 >UniRef50_C5EL38 D-3-phosphoglycerate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EL38_9FIRM Length = 311 Score = 372 bits (957), Expect = e-101, Method: Composition-based stats. Identities = 91/306 (29%), Positives = 138/306 (45%), Gaps = 10/306 (3%) Query: 21 QKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEK-LVAI 79 E L+AAG+ + + Q+ E + + + T++ + + L I Sbjct: 10 DAFEERLKAAGFQVVRTGERL--PAQIIECGKGCQAAVINAEDQWTKETMEGLKDTLGLI 67 Query: 80 GCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVW 139 F +G + VDLDAA GI V N+ +N SVAE + +L R + + K G W Sbjct: 68 ARFGVGLDNVDLDAARGLGIKVANSAGANKESVAECAVTLMLECTRRISWLDGKLRDGQW 127 Query: 140 NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQ--HL 197 K + + GK +G+IG+G I + +A+ G V D+ + Sbjct: 128 -KGLPRTHQFSGKTVGLIGFGAIAQCVAGMAKGFGCKVLACDVIKNETAAKRLDTVFCEM 186 Query: 198 SDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKH 257 +LL SD +SLHVP T++M+ + MKP ++LIN SRG VVD AL AL Sbjct: 187 DELLEKSDFISLHVPLTEDTRHMVSEAFLKKMKPTAILINTSRGPVVDEKALYRALKEGW 246 Query: 258 LAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSD 317 + A +DVF EP + PL N+++TPH ST+EA NI + Y + Sbjct: 247 IQAAGLDVFEQEPPGGDN----PLFGLHNIIVTPHAASSTEEAAGNIADLCMENICSYFE 302 Query: 318 NGSTLS 323 G Sbjct: 303 TGIPKY 308 >UniRef50_B0P693 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=B0P693_9FIRM Length = 322 Score = 372 bits (955), Expect = e-101, Method: Composition-based stats. Identities = 81/329 (24%), Positives = 148/329 (44%), Gaps = 13/329 (3%) Query: 8 KDKIKFLLVEGVHQK---ALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTH 64 K K ++ + ++ E +R AG ++H ++++ + D + Sbjct: 1 MKKPKVVISDYYYESIAQEREIIRQAGGELFDYHCA--TEDEVISAAADCDALIC-QFAP 57 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 +T VI A + I + IG + +DL AA ++G+ V N P + V+ I L+ + Sbjct: 58 ITARVIRAMPRCKVIVRYAIGVDNIDLKAAEEQGVYVCNVPDYSIDEVSNHAIALLMDCV 117 Query: 125 RGVPEANAKAHRGVWNKLAA-GSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE 183 + + ++ G + +G LG++G+G I + G+ + YD Sbjct: 118 KKLTFLASQVKAGRSSYTVVKPLHRMQGSTLGLMGFGRIPRLVAQKMAGFGLKMIAYDPM 177 Query: 184 NK--LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 LL SD +S+H P N ST+++ + LMKP ++L+N +RG Sbjct: 178 LDQQAAQELGVTPVSFEQLLMDSDYLSIHCPLNESTRHIFNQEAFRLMKPTAVLVNTARG 237 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 VVD AL AL+ +A A +DV EP + PL + DN ++TPH ++EA Sbjct: 238 AVVDEQALIQALSDGQIAMAGLDVTEQEPVAADN----PLLKLDNAVVTPHAAWYSEEAV 293 Query: 302 ENIGLEVAGKLIKYSDNGSTLSAVNFPEV 330 ++ +VA ++ + + + VN P++ Sbjct: 294 ASLQRKVAEEVARVLRGETPQNPVNHPKL 322 >UniRef50_A7VV70 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753 RepID=A7VV70_9CLOT Length = 316 Score = 372 bits (955), Expect = e-101, Method: Composition-based stats. Identities = 96/326 (29%), Positives = 150/326 (46%), Gaps = 20/326 (6%) Query: 11 IKFLLVE----GVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLT 66 +K ++++ + E L G + E+L E ++A + + ++T L+ Sbjct: 1 MKIVVLDGETTNPGDLSWERLEKLGELTVY---ARTKPEELYERAKEAE-LLITNKTVLS 56 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 +I + + L IG G N VD+ AA K GIPV N P T +VA++ L L Sbjct: 57 GKMIRSLKNLKYIGTLSTGFNVVDIHAARKLGIPVCNVPSYCTNAVAQMTFSLLFALTNH 116 Query: 127 VPEANAKAHRGVWNKLAAGSF------EARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 V N H+G W + E K G+ G+G IG + +A LGM V Y Sbjct: 117 VALHNHSVHQGDWENSTDFCYWKAPLVELESKNFGVYGFGSIGRTVAKIAADLGMNVLVY 176 Query: 181 DIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 K + + + +L SDV+SLH P P T ++ K +SLMKP + LIN SR Sbjct: 177 SRTKK-DMPSGYRWVSQEELFRESDVLSLHCPLTPETTGLVNRKTLSLMKPTAYLINTSR 235 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G V+ L +AL LAGAA+DV EP +P T + ++TPHI + +E+ Sbjct: 236 GQVIREQDLAEALNGGRLAGAAMDVLCEEPPEKGNPLTH----CEKCVITPHISWAAKES 291 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVN 326 ++ + V + + + + VN Sbjct: 292 RDRLLHTVCDNVEAFLKG-TPQNQVN 316 >UniRef50_D1VVP3 Phosphoglycerate dehydrogenase n=1 Tax=Peptoniphilus lacrimalis 315-B RepID=D1VVP3_9FIRM Length = 315 Score = 371 bits (953), Expect = e-101, Method: Composition-based stats. Identities = 106/314 (33%), Positives = 170/314 (54%), Gaps = 9/314 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+++ + ++ + L+ G + ++L + I D + +R + +D++ Sbjct: 1 MKALIIDQMSEEIDKGLKERGIEFKKVMLPK--KDELIKLIPDVDVLIMRVDPFIDKDIL 58 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +AA+ L I +GTN +DL+ KR IPV N+P N+ +VAELV + L L R +A Sbjct: 59 DAAKNLKLILVGSVGTNHIDLEECKKRNIPVMNSPGQNSNAVAELVFSKALDLYRNTVQA 118 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKLPL 188 N + G+WNK E R K +GI+GYG IG ++ +A M V YD K Sbjct: 119 NNEVKSGIWNKYRWIGRELRNKTMGILGYGSIGRRVAEIAHVFKMDVLAYDPYFDPKNNP 178 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + ++ L + L SDV++LH+P TKNM+ +K++ M+ G++LINA+RG V+D A Sbjct: 179 YDYVKLVSLDEALKNSDVITLHLPLTKETKNMISSKQMEGMRDGTILINAARGGVIDEDA 238 Query: 249 LCDALASKHLAGAAIDVFPTE-----PATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 L + + + L GA +D E T P +S L E D V ++PHIGGST +AQ++ Sbjct: 239 LYEYIKNGKLGGANLDTLADELGTGGLDTQDVPISSKLFELDRVYMSPHIGGSTIDAQDD 298 Query: 304 IGLEVAGKLIKYSD 317 IG V L ++ Sbjct: 299 IGHLVLQHLDEFLK 312 >UniRef50_Q7UQC8 Probable 2-hydroxyacid dehydrogenase n=3 Tax=Bacteria RepID=Q7UQC8_RHOBA Length = 406 Score = 370 bits (951), Expect = e-101, Method: Composition-based stats. Identities = 85/331 (25%), Positives = 141/331 (42%), Gaps = 11/331 (3%) Query: 2 AKVSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRS 61 +++ +E K L+ + ++L+ LR + E+L ++ H + Sbjct: 79 SRLGMETMKHSVLVTRQIPGESLKRLREVCEVEVWPEAIPPSREELCRLVKGRHGLLTML 138 Query: 62 RTHLTEDVIN-AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGEL 120 + ++++ A E+L + + +G N +D+DAA RG+ V N P T + A+L + L Sbjct: 139 SDRIDGELMDVAGEQLCVVSNYAVGFNNIDVDAAKTRGVVVGNTPDVLTDATADLAVSLL 198 Query: 121 LLLLRGVPEANAKAHRGVWNKLAAGS---FEARGKKLGIIGYGHIGTQLGILAES-LGMY 176 R V A + G W E K LGI+G G IG GM Sbjct: 199 FAASRHVLPAGNQVREGEWKTWEPTGWLGVEPSDKTLGIVGMGRIGKATAKRLVGGWGMN 258 Query: 177 VYFYDIEN--KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSL 234 + + + + + L LL SD VS+HV T+N++ A I MK S+ Sbjct: 259 LLYTSRSDQGDVEKELGGRRVELDTLLAESDFVSVHVALTDETRNLIDADAIGKMKSTSV 318 Query: 235 LINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIG 294 L+N +RG +VD AL DAL + + A +DV EP P L + + ++ PHIG Sbjct: 319 LVNTARGEIVDQDALVDALNRRAIFAAGLDVTTPEPL----PADHALVKSPHCVILPHIG 374 Query: 295 GSTQEAQENIGLEVAGKLIKYSDNGSTLSAV 325 +T ++ + LI +V Sbjct: 375 SATHTSRNAMSEIAVDNLIAGLAGKPLRCSV 405 >UniRef50_UPI000038E3F5 glyoxylate reductase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E3F5 Length = 311 Score = 369 bits (948), Expect = e-100, Method: Composition-based stats. Identities = 85/316 (26%), Positives = 142/316 (44%), Gaps = 13/316 (4%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + +E + + + L +I A I + + +++I+ Sbjct: 3 KILVTRNIPGNYIEKIENMEIEVFSGNGNM--RDWLLSNIGSADGILITLNEKIDKELID 60 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 +KL I + +G + +D++ A +GI V N P T + A+L+ G ++ R + N Sbjct: 61 HGKKLKVISTYSVGYDHIDVEYAKSKGIIVTNTPEVLTDATADLIFGLMIAAARNIVSGN 120 Query: 132 AKAHRGV----WNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP 187 H+ WN E GK LGIIG G IG + A M + +Y Sbjct: 121 DLIHKNDWKAGWNPTFMLGSEIHGKTLGIIGMGRIGKAIARRASGFDMKIIYYSRHRHDV 180 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + + +LL SD V + + N T + M ++IS MK + LIN +RG +V+ Sbjct: 181 DAD---FASIDELLQQSDFVIIALDLNADTFHFMDYQKISKMKKTAFLINGTRGKIVNEK 237 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 L AL K + GAA+DVF EP N++ P+ F NV++TPH+G +T E ++ + Sbjct: 238 DLVRALNEKIIEGAALDVFEDEPVDNTN----PILSFSNVVVTPHLGSATYETRDKMAET 293 Query: 308 VAGKLIKYSDNGSTLS 323 L+ + L Sbjct: 294 AVTNLVNVLNGKDPLY 309 >UniRef50_B8FRA5 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=78 Tax=Firmicutes RepID=B8FRA5_DESHD Length = 337 Score = 368 bits (947), Expect = e-100, Method: Composition-based stats. Identities = 88/330 (26%), Positives = 142/330 (43%), Gaps = 13/330 (3%) Query: 7 EKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLT 66 + K K L+ V Q+ E + + G + +L + + D + + +R + Sbjct: 10 DGSKPKVLIARQVPQEVEEWIGRHCEYSKWEGSGDIPRSELLKQLGDVDGLLI-NREKID 68 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 ++++AA KL + +G N D+ R + + P +VA+LV G +L R Sbjct: 69 GELLDAAPKLKIVANISVGYNNFDIGEMQARKVLGTHTPNVLDDTVADLVFGLMLSTARR 128 Query: 127 VPEANAKAHRGVWNKL---AAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDI 182 + E + G WN+ + + LGIIG G IG L + M + +++ Sbjct: 129 LCELDRYVKAGRWNETVTPDLFGMDVHHQTLGIIGMGRIGRALAQRGKWGFDMNILYHNR 188 Query: 183 ENKLPLGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 + L +LL SD V L P +P T N+M +E LMK ++ I+ASR Sbjct: 189 SRHPEAEQRFDARYCTLEELLQRSDFVVLLAPLSPQTVNLMSGREFGLMKRSAVFISASR 248 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G VD AL +AL + GA +DV+ EP P PL F NV+ PH+G +T Sbjct: 249 GETVDEEALVEALREGRILGAGLDVYRKEPI----PPDHPLLRFKNVVTLPHLGSATTRT 304 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVNFPEV 330 + + A L+ V PE+ Sbjct: 305 RLAMARMAAENLLIGLKREIPPQCV--PEL 332 >UniRef50_C4ZHF5 Phosphoglycerate dehydrogenase, putative n=3 Tax=Clostridiales RepID=C4ZHF5_EUBR3 Length = 329 Score = 367 bits (944), Expect = e-100, Method: Composition-based stats. Identities = 95/318 (29%), Positives = 155/318 (48%), Gaps = 12/318 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +KF++ + V + ++ L G ++ D + +RDA + +R + I Sbjct: 1 MKFVMTQAVCPEGMQLLD--GIADVYVADNQ-DPNNYLDEMRDAAALIVRIA-KCDANAI 56 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 + KL IG +G + VD+ A + GIPV P +N RSVAE + + L + + EA Sbjct: 57 ENSPKLKVIGRTGVGYDSVDVKKATELGIPVVITPGANNRSVAEHAVAMIFALSKNLIEA 116 Query: 131 NAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE---NKL 186 + +G W + A +FE K +GI+G G IG + + + GM + YD ++ Sbjct: 117 QNEMCKGNWEIRGAKKAFELERKTVGILGLGAIGRETAKICKGCGMRIAAYDPFMTKEQV 176 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 A + +LL SDVVS+HVP T+NM+ KE+S+MKP +L+IN SRG +++ Sbjct: 177 EGYGAKYYEDYVELLKDSDVVSIHVPLTDQTRNMISKKELSVMKPTALIINCSRGGIINE 236 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 L +AL + +AGA DVF +EP D PL N++++PH T+EA + Sbjct: 237 ADLVEALNNGVIAGAGTDVFCSEPPKTDD----PLLNCRNLIVSPHSAAQTREAVIKMAQ 292 Query: 307 EVAGKLIKYSDNGSTLSA 324 + + Sbjct: 293 MCIKGCLAVVEGKKWPYV 310 >UniRef50_UPI0001972FE9 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=1 Tax=Clostridium sp. M62/1 RepID=UPI0001972FE9 Length = 338 Score = 367 bits (944), Expect = e-100, Method: Composition-based stats. Identities = 106/317 (33%), Positives = 151/317 (47%), Gaps = 9/317 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + LL + + + + L GY ++ ++E + IR + +R +T+ ++ Sbjct: 3 FRILLPQPILESGRQYLLERGYELVD--GSGFEEEDIIRDIRGCDAMIVR-TAKITDRIL 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA++L I G + VDL+AA K+GI V AP +N++SVAEL + +L R Sbjct: 60 EAADRLKVIARHGAGFDGVDLEAARKKGILVLYAPKANSQSVAELAVFYILHCSRNFKLV 119 Query: 131 NAKAHRG-VWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIENKLPL 188 + K E GK LG+IG G+IG + A M V +D K Sbjct: 120 QKLYRDDYRFAKFNVEKHELNGKTLGLIGVGNIGGLVAKKAALGFDMKVIAFDPYAKELP 179 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + ++ +D VSLHVP P T N +G KE LMKP + LIN SRG+VVD A Sbjct: 180 DYIEVAESREEVFEKADYVSLHVPATPETVNSVGEKEFRLMKPTAFLINTSRGSVVDEEA 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L AL K +AGAA+DV EP + PL E DNV+ PHIG +T+EA L Sbjct: 240 LIRALNEKEIAGAALDVLKQEPIDKDN----PLLEMDNVVTAPHIGAATKEASARASLIC 295 Query: 309 AGKLIKYSDNGSTLSAV 325 A + Y V Sbjct: 296 AQGIDDYLSGRKPEFVV 312 >UniRef50_A0Y9Y1 Glyoxylate reductase n=3 Tax=unclassified Gammaproteobacteria RepID=A0Y9Y1_9GAMM Length = 326 Score = 367 bits (944), Expect = e-100, Method: Composition-based stats. Identities = 90/331 (27%), Positives = 142/331 (42%), Gaps = 12/331 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K + + + L L + KG++ ++L + I + ++IN Sbjct: 3 KVFVTYNMPAEQLSRLSEYCDVDAWQGKGSIPRDELMARVEGVDGIICLLTERIDGELIN 62 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 +++ L A+ C +G + VD+ RGIP+ + P + A+L G LL R +P+ + Sbjct: 63 SSKNLKAVSCVSVGVDHVDVGTLTARGIPLGHTPGVLVDATADLAFGLLLAAARRIPQGD 122 Query: 132 AKAHRGVWN-----KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL 186 G W A GK LGIIG G IG L A M V + + Sbjct: 123 RHVRTGGWQGASWSPKAFLGCSVAGKTLGIIGLGDIGQALARRAAGFDMPVIAWSRSGRE 182 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + L +L+ SD VS++V T+ ++ A +S MKPG++L+N +RG +VD Sbjct: 183 VA--GVRTLSLEQVLDQSDFVSINVALTEETRGLIDAAALSKMKPGAILVNTARGGIVDE 240 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL AL +AGA DVF EP + + L + N + TPHIG +T E + + Sbjct: 241 RALAQALKEGRIAGAGFDVFEKEPVSPGN----ALFDQPNFIATPHIGSATPETRLAMMD 296 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEVSLPLHGG 337 + + N PEV H Sbjct: 297 LAVANMCAAMWSEKMPCCFN-PEVYADHHDN 326 >UniRef50_A1HMI9 Phosphoglycerate dehydrogenase n=1 Tax=Thermosinus carboxydivorans Nor1 RepID=A1HMI9_9FIRM Length = 326 Score = 366 bits (941), Expect = e-100, Method: Composition-based stats. Identities = 102/324 (31%), Positives = 168/324 (51%), Gaps = 16/324 (4%) Query: 11 IKFLLVEGVHQKALESLRA---AGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 IK + + V +E + + +G T ++ +++ +++ A + + +T+ Sbjct: 2 IKVIYFDKVFPDMVELIESIKPSGVTVTYWYTLNDKEKE--QALNSADYFLVALY-KITQ 58 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 ++I A KL I +G + +DL AA GIPV N P N SVAEL +G ++ L R + Sbjct: 59 ELIQKAPKLKMIQKTGVGVDNIDLAAAKTLGIPVANTPGGNATSVAELTLGMIINLYRKI 118 Query: 128 PEANAKAHRGVWNKLAAG--SFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 + + +G W S+E +GK GIIG+G+IG ++ L+++ G V +YD+ Sbjct: 119 NILDRETKKGNWMSWEFRPSSYEVKGKTHGIIGFGNIGREVARLSQAFGTNVIYYDLRRL 178 Query: 186 LPLGNA---TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 P L++LL SD++S+H+P P TKN++ +E++L+KP +LLIN +RG Sbjct: 179 EPAEEKRLNVTYHELNELLQKSDIISIHLPLTPDTKNLISERELALLKPTALLINVARGN 238 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 +VD AL AL L GA IDV+ EP +PL +NVL TPHIG T++ + Sbjct: 239 IVDEVALYRALKENKLLGAGIDVWSKEPVE-----DNPLLTLNNVLATPHIGAGTRDTLQ 293 Query: 303 NIGLEVAGKLIKYSDNGSTLSAVN 326 + +I + + VN Sbjct: 294 TVLGLAFENIIATTRGKNPRFVVN 317 >UniRef50_A9BJ57 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=5 Tax=Thermotogaceae RepID=A9BJ57_PETMO Length = 310 Score = 366 bits (941), Expect = e-100, Method: Composition-based stats. Identities = 98/307 (31%), Positives = 162/307 (52%), Gaps = 6/307 (1%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K + + + + AL+ L+ ++E L+ + LK+ I++ + +RS T +T++++ Sbjct: 1 MKIHINDPLDENALKKLQNE-LPDLEITSEHLEKDVLKDKIKEIDVLIVRSATKVTKEIL 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A+KL + +G + +D+D A +GI V N P N+ SVAELVIG +L + R + Sbjct: 60 EHADKLKIVARAGMGLDNIDVDTAKLKGITVLNTPGQNSLSVAELVIGMVLDIYRHITRG 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 W K FE K GIIG+G++G L L + YD+ Sbjct: 120 TIGLKNEQWEKKQLEGFELSQKTFGIIGFGYVGKNLAQLLKGFQTNTLVYDVFEISAEEQ 179 Query: 191 A---TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + L +LL SD++SLH+P+N T + + +I +MK G+++INA+RG V+D Sbjct: 180 KNYNVRQVSLEELLQNSDIISLHIPKNEKTYHFISEPQIKMMKDGAVIINAARGGVLDEN 239 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 + L + L G +DVF EP F L NV+LTPHIG ST+EAQE +G+ Sbjct: 240 YVLKYLKNGKLLGVGLDVFEEEPPKGD--FYKELFALPNVVLTPHIGASTKEAQERVGIN 297 Query: 308 VAGKLIK 314 + ++++ Sbjct: 298 IVDRVVE 304 >UniRef50_A5N5A9 SerA n=3 Tax=Clostridium RepID=A5N5A9_CLOK5 Length = 320 Score = 366 bits (940), Expect = 1e-99, Method: Composition-based stats. Identities = 102/320 (31%), Positives = 160/320 (50%), Gaps = 11/320 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ E + ++ +E L+ GY ++ L E ++D I +R ++TE VI Sbjct: 4 KILITESIEEEGVEYLKKFGYEI--KMPRDTSEDVLIEEVKDCDAILVR-MANITEKVIR 60 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A +KL I F +G N VD+ A++ I + NAP SN +VAE +G ++ L + + Sbjct: 61 AGKKLKVISRFGVGVNNVDIKTASELSIQITNAPESNKNTVAEYTMGLIIALAKKFFLYD 120 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILA-ESLGMYVYFYDIENKLPLGN 190 +G + + GK LGI+G G IG L + A + GM V + + Sbjct: 121 RGLRKGNFKVRDILGIDLEGKVLGIVGLGSIGKLLALKASKGFGMKVIGFKRHIDEESKS 180 Query: 191 ATQVQ---HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 V+ L +L SD VSL+VP +T ++G +E+S MK + LIN +RG VVD Sbjct: 181 LDYVELTDSLDYVLENSDFVSLNVPLTKATTKIIGKRELSFMKKDAFLINTARGEVVDND 240 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 ALC+AL +K +AGAA DVF E + + P+ + +NV++TPH T EA + + + Sbjct: 241 ALCNALLNKQIAGAATDVFDGEIPSKDN----PIFKMENVIVTPHSAAHTIEAMKRMSVH 296 Query: 308 VAGKLIKYSDNGSTLSAVNF 327 A + + VN Sbjct: 297 AAIGIHEVLSGNKPSWPVNI 316 >UniRef50_B8FRV3 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Desulfitobacterium hafniense RepID=B8FRV3_DESHD Length = 320 Score = 366 bits (940), Expect = 1e-99, Method: Composition-based stats. Identities = 99/311 (31%), Positives = 149/311 (47%), Gaps = 11/311 (3%) Query: 18 GVHQKALESLRAAGYTNIEFHKGAL-DDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKL 76 +A L G + L + E K + +AH + + + + AA L Sbjct: 15 KYSPQAAGILEKKGCRLVMIPPNGLREREDFKAVLAEAHVWVV-GINKVYAEDLEAAPNL 73 Query: 77 VAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHR 136 I G + +DL AAA RGI V NAP +N SVA+L G +L L R + A+ + Sbjct: 74 KLIIKHGTGVDSIDLKAAAARGITVANAPGTNANSVADLAFGFMLSLARQIVSADKRTRD 133 Query: 137 GVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IENKLPLGNATQV 194 G W + GK LG++G G IG + A M + YD ++ + Sbjct: 134 GFW--GTVMGKDVYGKTLGVLGLGQIGKGVIRRASGFDMNILGYDLVHHSQFEKEYRVRA 191 Query: 195 QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALA 254 L ++++ +D +S+H+P STKN++ + M+P + LIN SRG VVD AL D L Sbjct: 192 ATLEEIMSEADYISVHLPLLESTKNIIDRSLLEKMRPTAFLINTSRGGVVDETALYDLLK 251 Query: 255 SKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIK 314 K +AGAA+DVF TEP P SP E DNV++ PH+G T+ A + +A +++ Sbjct: 252 EKRIAGAALDVFATEP-----PRQSPFFELDNVIVAPHMGAYTEGAMGAVSEILAESIVR 306 Query: 315 YSDNGSTLSAV 325 LS + Sbjct: 307 VLAGKEPLSVI 317 >UniRef50_B2I1D3 Phosphoglycerate dehydrogenase n=2 Tax=Acinetobacter baumannii RepID=B2I1D3_ACIBC Length = 325 Score = 366 bits (940), Expect = 1e-99, Method: Composition-based stats. Identities = 95/323 (29%), Positives = 155/323 (47%), Gaps = 11/323 (3%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRD--AHFIGLRSRTHLTE 67 K K L+ + + + + +++++ I D I +R+ L+ Sbjct: 2 KRKVLITGPTLTSDALLYAQSHDIQLIPTEPYMAKDKMEKLIHDEQPDAIIVRTG-KLSR 60 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 D+I A++ L I +G + +D AAA+R IPV A +N +SVAE + + R V Sbjct: 61 DMIFASDNLKVIAKHGVGFDTIDTQAAAERKIPVTIAVGANAQSVAEHAFALMFNVARQV 120 Query: 128 PEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK-- 185 + + G W+K +A E GK LG+IG G IG+ L L L M V YD + Sbjct: 121 TWLDQRIREGHWDKASANGVELYGKTLGLIGLGAIGSILMKLVAPLNMKVKVYDPFLQNL 180 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 L Q L+ SD++SLH P K++ + MK S+LIN +RG ++D Sbjct: 181 PELDYVEQEHDFEKLIETSDIISLHCPLTAENKHLFSHSQFEKMKSSSILINTARGELID 240 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL DAL + +AGA +D F +EP + PL E N+++TPHIG +T +++ +G Sbjct: 241 QAALVDALKNNKIAGAGLDTFSSEPPEKDN----PLWELPNLVVTPHIGANTTDSRNRVG 296 Query: 306 LEVAGKLIKYSDNG--STLSAVN 326 L +++ + + + N Sbjct: 297 LLALEQIMSIWNGQLLNPRAIAN 319 >UniRef50_Q71VT7 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=114 Tax=Bacilli RepID=Q71VT7_LISMF Length = 403 Score = 365 bits (938), Expect = 2e-99, Method: Composition-based stats. Identities = 104/372 (27%), Positives = 165/372 (44%), Gaps = 30/372 (8%) Query: 54 AHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVA 113 A I LRS D + A+ G N + ++ +++GI VFN P +N +V Sbjct: 39 ADGILLRSYNLHDFDFPET---VKAVARAGAGVNNIPVENCSEKGIVVFNTPGANANAVK 95 Query: 114 ELVIGELLLLLRGVPEANAKAHRG----------VWNKLAAGSFEARGKKLGIIGYGHIG 163 ELV+ L + R + E K A E GKKLGIIG G IG Sbjct: 96 ELVLASLFVSARPILEGTEWVKELPAEDDVEQKVEAGKKAFAGTELAGKKLGIIGLGAIG 155 Query: 164 TQLGILAESLGMYVYFYDIENKLPLG-----NATQVQHLSDLLNMSDVVSLHVPENPSTK 218 + A SLGM V YD + + + ++L D +++HVP T+ Sbjct: 156 ALVANDALSLGMDVVGYDPFVSVDTAWRISKEVERAMTIEEVLATCDYLTVHVPLTDKTR 215 Query: 219 NMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFT 278 M A + L+K ++L+N SRG +VD ++ +AL L D E Sbjct: 216 GMFNADTLQLVKDNAVLLNFSRGELVDSASVKEALDDGLLRLYITDFATKE--------- 266 Query: 279 SPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGR 338 L V + PH+G ST+EA+ N A +L Y + GS ++VNFP V +P +G Sbjct: 267 --LLNHKKVHVFPHLGASTEEAETNCAKMAAKELQSYLETGSIKNSVNFPNVEMPYNGHP 324 Query: 339 RLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDV-AEKALQAM 397 R+ H+N P ++ + + +NI ++ + Y +IDI+ + E+ + Sbjct: 325 RIGICHKNIPNMVGQITTELGKYSLNILDMINRSKNEYAYTLIDIDKETQANLEQLKSDL 384 Query: 398 KAIPGTIRARLL 409 A+ G +R R++ Sbjct: 385 LAVQGVLRVRVI 396 >UniRef50_A9A1H5 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=4 Tax=Archaea RepID=A9A1H5_NITMS Length = 310 Score = 365 bits (938), Expect = 2e-99, Method: Composition-based stats. Identities = 110/309 (35%), Positives = 161/309 (52%), Gaps = 10/309 (3%) Query: 13 FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINA 72 L+ + V + L+ G ++ + EQ+ E I D + + +RSRT +T+++I+ Sbjct: 7 VLICDEVDPILNKILQDNGLKI--SYEPEITPEQILEKISDYNIVIVRSRTTITKEMIDK 64 Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA 132 A+ I +G + VD +AA + I V NA +VAELV+G +L L R + Sbjct: 65 ADNCKIIARVGVGLDNVDQEAAKAKNIRVINAVEGAMNAVAELVLGLMLSLARQTARGDR 124 Query: 133 KAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL---G 189 W K E GK LGI+G G+IG +LG LA +L M + YD+ Sbjct: 125 GIRNEQWLKKELKGTELAGKYLGIVGLGNIGKRLGRLARALNMNIIGYDVVPIDEEFSKE 184 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 L+ LL +D VS+HVP ST +++ A+++S MK + +IN SRG VVD AL Sbjct: 185 VGLMKADLNTLLQSADYVSIHVPLLDSTYHLLDAQKMSTMKKTAKIINTSRGGVVDEDAL 244 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 DAL + L GAA+DVF EPA + L E DNV+LTPHIG T+EAQ +A Sbjct: 245 YDALKNGTLGGAALDVFEKEPA-----IGTKLAELDNVILTPHIGAQTKEAQSLAANVIA 299 Query: 310 GKLIKYSDN 318 K+++ Sbjct: 300 EKIVQILRG 308 >UniRef50_C6PA05 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Thermoanaerobacterales RepID=C6PA05_CLOTS Length = 355 Score = 365 bits (937), Expect = 2e-99, Method: Composition-based stats. Identities = 100/324 (30%), Positives = 155/324 (47%), Gaps = 15/324 (4%) Query: 7 EKDKIKFLLV----EGVHQKALESLRAAGYTNIEFHKG-ALDDEQLKESIRDAHFIGLRS 61 K +K L+ E L+ Y I G ++++LKE I+D + + Sbjct: 34 AKMTMKVLITPRSFGKTSNIPFEMLKKYDYEIIRNETGKPYEEDELKELIKDVDGVIV-G 92 Query: 62 RTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELL 121 +TEDV+ A+KL I + +G + +D++ A K GI V P +N SVA+L +L Sbjct: 93 LDKITEDVLKNAKKLKVITKYGVGLDNIDINYAEKLGIKVTYTPGANKESVADLAFTMML 152 Query: 122 LLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD 181 L R + + + WNK E GK +GIIG G IG + A M + YD Sbjct: 153 GLSRDIIKLDKIVRNNQWNK--IIGCEIYGKTIGIIGTGSIGKCVAKRATGFDMEILAYD 210 Query: 182 IENKLPLGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINAS 239 + + LL SD ++LHVP + + +E+++MK + +IN S Sbjct: 211 KYPDYDFADKIGMKYVDKKTLLEKSDFITLHVPLTDEMYHFIDEEELNMMKDTAYIINTS 270 Query: 240 RGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQE 299 RG +++ AL AL SK +AGAA+D F TEP P + L E DN++L+PH G ST++ Sbjct: 271 RGGIINENALYSALKSKKIAGAALDAFETEP-----PLNNKLLELDNIILSPHCGASTKD 325 Query: 300 AQENIGLEVAGKLIKYSDNGSTLS 323 A + +G+ LI + Sbjct: 326 ATDRMGIMAVEGLISVLEGMEPKY 349 >UniRef50_A0Q365 D-isomer specific 2-hydroxyacid dehydrogenases n=11 Tax=Bacteria RepID=A0Q365_CLONN Length = 317 Score = 364 bits (936), Expect = 3e-99, Method: Composition-based stats. Identities = 103/321 (32%), Positives = 156/321 (48%), Gaps = 13/321 (4%) Query: 11 IKFLLVEGVHQKALES------LRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTH 64 ++ ++E + E + G+ I F D + L E +DA + L + Sbjct: 1 MRISVLEPLGLPKEEVYSIAKPIIDKGHEVILFEDKVQDKKVLMERAKDAEVLVLAN-MP 59 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 L +VI + +KL I G + VD A ++ + V NA +T SVAEL G + +L Sbjct: 60 LEGEVIKSDDKLKMISVAFTGIDHVDTKACTEKQVMVCNAAGYSTSSVAELTYGLIFSVL 119 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE- 183 R + + G + E GK +GI+G G IG ++G +A++ G V Y Sbjct: 120 RNIVPLDKATREGK-TRNGFSQNEILGKTIGIVGTGAIGIRVGQIAKAFGCNVLAYSRSE 178 Query: 184 NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 K + + L +LL+ SD+VSLHVP N TK ++ ++I LMK S+LIN +RG V Sbjct: 179 RKEAIDTGFKYVSLDELLSKSDIVSLHVPLNDETKGLISKEKIELMKSSSILINTARGPV 238 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 VD AL +AL + GA IDVF EP + + PL NV++TPHI +T+EA Sbjct: 239 VDNSALAEALKKGKIKGAGIDVFEIEPPISKE---HPLFNAPNVVVTPHIAFATEEAMYR 295 Query: 304 IGLEVAGKLIKYSDNGSTLSA 324 V + K+ D S + Sbjct: 296 RCEIVFKNIEKWLDG-SPQNV 315 >UniRef50_Q04AA8 Lactate dehydrogenase related enzyme n=3 Tax=Firmicutes RepID=Q04AA8_LACDB Length = 316 Score = 364 bits (935), Expect = 4e-99, Method: Composition-based stats. Identities = 92/320 (28%), Positives = 151/320 (47%), Gaps = 13/320 (4%) Query: 11 IKFLLVEG--VHQKALESLRAA----GYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTH 64 +K +L+E + Q++L+ L G+ + + D E+LK+ DA + + + Sbjct: 1 MKIVLLEPLGISQESLDKLAEKLTKQGHEFTAYDSFSTDTEELKKRSEDADALIIANH-L 59 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 L +VI A + L I +G + VDL+A ++ I + N +VAEL IG L L Sbjct: 60 LPGEVIRADKNLKFISVAFVGIDHVDLEACKEKKINISNTGGYCNDAVAELAIGLTLDCL 119 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 R + N G K E GK +GI+G G IG + + ++ G + Y Sbjct: 120 RKISAGNEAVQAGE-GKGGLQGHELAGKTVGIVGTGAIGCRTAEIFKAFGCKLIGYSRSQ 178 Query: 185 KLPL-GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 K + + L +++ +D+VS+H P P TK ++G KEI MK G++LIN +RG V Sbjct: 179 KAAALDLGLEYKSLDEVMGEADIVSIHTPLTPETKGLIGKKEIGEMKEGAILINTARGPV 238 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 VD AL AL + A +DVF +P P PL N++ +PH+G T+E+ + Sbjct: 239 VDTEALAAALKEGRIK-AGLDVFDQDPPL---PADYPLLGVPNLVCSPHVGFDTKESIDR 294 Query: 304 IGLEVAGKLIKYSDNGSTLS 323 + + + + Sbjct: 295 RAEMAFENVTAWLNGQQIRT 314 >UniRef50_P0A545 D-3-phosphoglycerate dehydrogenase n=57 Tax=Actinomycetales RepID=SERA_MYCBO Length = 528 Score = 364 bits (935), Expect = 4e-99, Method: Composition-based stats. Identities = 112/385 (29%), Positives = 180/385 (46%), Gaps = 14/385 (3%) Query: 13 FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINA 72 L+ + + + +L G D ++L ++ +A + +RS T + +V+ A Sbjct: 6 VLIADKLAPSTVAAL---GDQVEVRWVDGPDRDKLLAAVPEADALLVRSATTVDAEVLAA 62 Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA 132 A KL + +G + VD+DAA RG+ V NAP SN S AE + LL R +P A+A Sbjct: 63 APKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASRQIPAADA 122 Query: 133 KAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN-- 190 W + + E GK +G++G G IG + + G YV YD Sbjct: 123 SLREHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAAQL 182 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 ++ L DLL +D +S+H+P+ P T ++ + ++ KPG +++NA+RG +VD AL Sbjct: 183 GIELLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALA 242 Query: 251 DALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAG 310 DA+ H+ A +DVF TEP T SPL E V++TPH+G ST EAQ+ G +VA Sbjct: 243 DAITGGHVRAAGLDVFATEPCT-----DSPLFELAQVVVTPHLGASTAEAQDRAGTDVAE 297 Query: 311 KLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYL 370 + AVN ++ + GVL + E V+++ Q Sbjct: 298 SVRLALAGEFVPDAVNVG--GGVVNEEVAPWLDLVRKLGVLAGVLS--DELPVSLSVQVR 353 Query: 371 QTSAQMGYVVIDIEADEDVAEKALQ 395 A V+ + A + ++ Sbjct: 354 GELAAEEVEVLRLSALRGLFSAVIE 378 >UniRef50_A8MD25 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8MD25_CALMQ Length = 326 Score = 363 bits (934), Expect = 5e-99, Method: Composition-based stats. Identities = 96/329 (29%), Positives = 152/329 (46%), Gaps = 20/329 (6%) Query: 14 LLVEGVHQKAL-ESLRAAGYTN---------IEFHKGALDDEQLKESIRDAHFIGLRSRT 63 L K L ++LR AG+ + A + L+++ + + Sbjct: 2 YLTRSTFPKLLYDTLRNAGFDLEVWDNKGHGMWDRAAAPPRDVLRDAASRCDALVVTIGD 61 Query: 64 HLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLL 123 + + V++ A K+ I + +G + +DLDAA +RGIPV P +VA+L IG ++ L Sbjct: 62 RVDDYVLSNA-KVKVIATYSVGYDHIDLDAATRRGIPVGYTPEVLVEAVADLAIGLIITL 120 Query: 124 LRGVPEANAKAHRGVWNK--LAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD 181 R V E + G K E GK LGI+G G+IG + A++ M V ++ Sbjct: 121 ARRVIEGDRLVRSGEAYKVWGEFLGTEVWGKTLGILGLGNIGAAVARRAKAFNMNVIYWS 180 Query: 182 IENKL--PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINAS 239 K + + L++L SD + L V + T +++ + + LMK S L+N + Sbjct: 181 RTRKPWIEVALGLRYVDLNELFRQSDYLVLTVALSKETYHIVNEERLRLMKNTSYLVNVA 240 Query: 240 RGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQE 299 RG VVD AL AL +AGAA+DV+ EP P T L + +NV+LTPHI +T E Sbjct: 241 RGAVVDTNALVKALKEGWIAGAALDVYEEEPI----PNTHELIKLNNVILTPHIASATVE 296 Query: 300 AQENIGLEVAGKLIKY-SDNGSTLSAVNF 327 + + A +I N + N Sbjct: 297 TRNKMAEVTALNVINVLLKNTKPVYQANM 325 >UniRef50_Q160B1 Glyoxylate reductase n=24 Tax=Bacteria RepID=Q160B1_ROSDO Length = 330 Score = 363 bits (934), Expect = 6e-99, Method: Composition-based stats. Identities = 87/334 (26%), Positives = 147/334 (44%), Gaps = 14/334 (4%) Query: 1 MAKVSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLR 60 M ++ K++ + L+ + L T + + ++++ I Sbjct: 1 MNAPAILKNRPRVLVTRRWPESVEAQLAERFDTVFNVDDTPMTPAEFRDALTRFDAILPT 60 Query: 61 SRTHLTEDVIN-AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGE 119 LT + + ++ K + + +G + +D+ AA GI V N P + A+L + Sbjct: 61 VTDRLTTEAFDISSPKTRLLANYGVGFSHIDIAAAKAHGIAVTNTPDVLSECTADLAMTL 120 Query: 120 LLLLLRGVPEANAKAHRGVWNKLAAG---SFEARGKKLGIIGYGHIGTQLGILAE-SLGM 175 LL++ R E + G W + GK LGI+G+G IG + A GM Sbjct: 121 LLMVARRAGEGERELRAGQWTGWRPTHLVGSKVSGKTLGIVGFGRIGQAMAQRAHFGFGM 180 Query: 176 YVYFYDIENKL----PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKP 231 + + A QV L DLL D VS+H P ++++ ++ + LMK Sbjct: 181 KILVQNRSRVAQEVLDRYQAVQVDTLDDLLPACDFVSMHCPGGAENRHLINSRRLDLMKS 240 Query: 232 GSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTP 291 + LIN +RG VVD AL +L + +AGA +DVF EP + L EFDN++L P Sbjct: 241 DAFLINTARGEVVDENALVQSLTYECIAGAGLDVFDGEPKVSP-----ALMEFDNLVLLP 295 Query: 292 HIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAV 325 H+G +T E + +G V +I + + + V Sbjct: 296 HLGSATAETRTAMGERVLSNVIAFFEGSTPADRV 329 >UniRef50_B0PD17 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PD17_9FIRM Length = 388 Score = 363 bits (933), Expect = 6e-99, Method: Composition-based stats. Identities = 103/413 (24%), Positives = 177/413 (42%), Gaps = 45/413 (10%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + + ++ + Y + + + I +RS ++ Sbjct: 3 HIKTLNKISPYGMDVFDRSKYICGDHVEAP-------------NGILVRSAAMHDMEL-- 47 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 +L AI G N + +D +++GI VFN P +N +V ELVI LL+ R V A Sbjct: 48 -GPELAAIARAGAGVNNIPVDRCSEQGIVVFNTPGANANAVKELVICALLMSARRVFPAM 106 Query: 132 AKAH--RGVWN---------KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 +G + K E GK LG+IG G IG ++ A L M V+ Y Sbjct: 107 EWVQTLKGQGDEVPKLVEKGKSQFVGPELAGKSLGVIGLGAIGARIANFARHLDMEVWGY 166 Query: 181 DIENKLPLGNAT-----QVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLL 235 D + + L ++ D ++LH+P P TK M+ ++ I +M+ G L Sbjct: 167 DPYMSVETAWNVSRSIRRASSLKEIYENCDFITLHIPSTPETKGMINSQSIQMMRHGVRL 226 Query: 236 INASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGG 295 +N +RG ++ L L K + D E L V+ PH+G Sbjct: 227 LNFARGDLIVNEDLLAGLEEKQIRCYFTDFPSDE-----------LLGHPGVMAIPHLGA 275 Query: 296 STQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALN 355 ST E+++N A +L+ Y +NG+ ++VN P VS+P G R+ IH N P +LT ++ Sbjct: 276 STPESEDNCARMAAEELVDYLENGNIKNSVNMPSVSMPRSGDFRVALIHRNIPAMLTKIS 335 Query: 356 KIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARL 408 + ++ G+NI ++ Y +ID++ ++ ++A+ IR + Sbjct: 336 VLISDAGMNIENLTNKSRQNYAYTMIDLK--GAPTDELAAKLRAVEDVIRVTI 386 >UniRef50_C5PUM3 Glyoxylate reductase n=2 Tax=Sphingobacterium spiritivorum RepID=C5PUM3_9SPHI Length = 329 Score = 363 bits (933), Expect = 7e-99, Method: Composition-based stats. Identities = 92/327 (28%), Positives = 140/327 (42%), Gaps = 11/327 (3%) Query: 8 KDKIKFLLVEGVHQKALESLRAAGYT-NIEFHKGALDDEQLKESIRDAHFIGLRSRTHLT 66 KD +K + V Q+ L L G T + L E++ + A + L Sbjct: 2 KDIMKVYISRNVPQEGLNYLTEHGLTYTVNMENKKLTQEEVIIECQSADLLLNVGGVPLD 61 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 + + L I +G + VD+DAA+K GIPV N P + + A++ +L + R Sbjct: 62 QHFFDNCAHLKGIALASVGYDHVDMDAASKAGIPVSNTPDVLSGATADVAFLLMLAVSRK 121 Query: 127 VPEANAKAHRGVWNKLAAG---SFEARGKKLGIIGYGHIGTQLGILAES-LGMYVYFYDI 182 + G WN E GK LGI G G IG +L A++ GM V +++ Sbjct: 122 AFYRANEIREGKWNDFEFTKDLGIELNGKTLGIYGLGRIGLELARKAQAAYGMKVIYHNR 181 Query: 183 ENKLPLGNA--TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 + + +LL SDV+S+H +P T+ + + MK ++LIN R Sbjct: 182 HPNETAKRVLNAEYVNFDELLTRSDVLSVHANLSPETQYRFNKETFARMKNSAILINTGR 241 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G +V L AL + + GA +DV EP SPL +V + PHIG +T E Sbjct: 242 GKIVHEQDLYTALVNGDIWGAGLDVTDPEPMKAD----SPLLTLPSVCVLPHIGSATIET 297 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVNF 327 + N+ A LI S + VN Sbjct: 298 RTNMIKMAANNLIAASKSNHMPQIVNV 324 >UniRef50_Q3SK87 D-isomer specific 2-hydroxyacid dehydrogenase n=13 Tax=Bacteria RepID=Q3SK87_THIDA Length = 391 Score = 363 bits (933), Expect = 7e-99, Method: Composition-based stats. Identities = 117/414 (28%), Positives = 190/414 (45%), Gaps = 46/414 (11%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L + + + L L + + D I +RS ++ Sbjct: 6 KILTLNAISARGLARLPEHYVVGGD--------------LADPDAILVRSANMHEMEIP- 50 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 + AIG GTN + + ++RG+PVFNAP +N +V ELVI +L+ R + A Sbjct: 51 --TSVCAIGRAGAGTNNIPVKKMSERGLPVFNAPGANANAVKELVIAGMLMGARNLVPAL 108 Query: 132 AKA-----------HRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 K E G+ LG+IG G IG+ + A LGM V Y Sbjct: 109 KFVESLDGTDEAMHKATEAGKKQFAGMELPGRTLGVIGLGAIGSHIAEAAIRLGMNVVGY 168 Query: 181 DIENKLPLG-----NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLL 235 D + + +++ D+L +D V+LHVP +T+N++ A+ +SLM+ G++L Sbjct: 169 DPAITVDAAWRLPSQVKRAENVDDVLRTADFVTLHVPLLDATRNLINAQRLSLMRSGAVL 228 Query: 236 INASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGG 295 +N +R VVD A+ +AL + L D + L V+ PH+G Sbjct: 229 LNFAREGVVDNAAVIEALDAGKLHAYICD-----------FPANALKGHPKVVALPHLGA 277 Query: 296 STQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALN 355 ST+EA+EN + VA +L Y +NG+ L++VNFP V++P RL + N P ++ ++ Sbjct: 278 STEEAEENCAVMVAEQLTDYLENGNILNSVNFPSVAMPRESAFRLAIANANVPNMVGQIS 337 Query: 356 KIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 + A G+NI ++ M Y ++D+ D VA + + AI G + R L Sbjct: 338 SVLAAAGLNIHNMVNKSKGDMAYTLVDV--DSAVAGSVIAQLNAIGGVLGVRYL 389 >UniRef50_UPI000197AFFA hypothetical protein BACCOPRO_00987 n=1 Tax=Bacteroides coprophilus DSM 18228 RepID=UPI000197AFFA Length = 315 Score = 362 bits (931), Expect = 1e-98, Method: Composition-based stats. Identities = 107/316 (33%), Positives = 159/316 (50%), Gaps = 12/316 (3%) Query: 11 IKFLLVEG--VHQKAL----ESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTH 64 + +L+E + + L L AG+ + LD + E R+A I + + Sbjct: 1 MNIVLLESLGISPERLSEYARPLVEAGH-TFNAYPRDLDIQVQIERAREADVIIIAN-MP 58 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 L +VI A + L I G + VDLDAA + G+ V NA +T++VAEL + +L LL Sbjct: 59 LRGEVIRACKHLKFIDVAFTGVDHVDLDAARECGVKVSNAAGYSTQAVAELALCMMLSLL 118 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 R VP+ + +G K E RGK +GI+G G IGT+ L ++ G V Sbjct: 119 RNVPQVAGRCRQGK-TKDGLVGCELRGKTVGIVGAGAIGTRTAELCKAFGCRVLGNKRHL 177 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + + L +LL+ SD+VSLH P T+ ++ A + +MK G+ LIN +RG VV Sbjct: 178 TGKEPSFIEFMPLEELLSQSDIVSLHCPLTAETRQLINADRLGMMKQGAYLINTARGGVV 237 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL +AL + +LAGA IDVF TEP + PL + NVL TPH+ +++E+ E Sbjct: 238 DSAALAEALKNGYLAGAGIDVFETEPPLDP---AHPLLQAPNVLATPHVAFASEESMEAR 294 Query: 305 GLEVAGKLIKYSDNGS 320 V L + D Sbjct: 295 AAIVFSNLSNWMDGKQ 310 >UniRef50_B3SAF7 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3SAF7_TRIAD Length = 324 Score = 362 bits (931), Expect = 1e-98, Method: Composition-based stats. Identities = 81/330 (24%), Positives = 133/330 (40%), Gaps = 26/330 (7%) Query: 12 KFLLVEGVHQKALESLRAAGY-TNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + + + + + L+ G + A+ ++L ++I + + +DV+ Sbjct: 3 RVYVTRCLPEDSARLLQKDGINVVMRSTDDAIPRQELLDNIPGCDALICMLTDKVDKDVL 62 Query: 71 NAA------------EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIG 118 +AA L I +G + +DLD KR I V N P +T +VAEL + Sbjct: 63 DAAGKHDTKLNHLTSPSLKVIATVSVGFDHIDLDECKKRNIVVSNTPRVSTDAVAELTVA 122 Query: 119 ELLLLLRGVPEANAKAHRGVWNKLAAG---SFEARGKKLGIIGYGHIGTQLGILAESLGM 175 LL R + E G W E RG +GI G G IG + + G+ Sbjct: 123 LLLATSRRLMECANAVKNGDWKSWGLLWMCGTELRGSTVGIFGLGRIGIAIATRLQCFGV 182 Query: 176 YVYFYDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLL 235 ++Y + DLL D + ++ P T + K + MK +L Sbjct: 183 KQFYY------TDIVEVPQVEIEDLLKSCDFIIINCALTPETAGLFNEKAFAKMKNNCVL 236 Query: 236 INASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGG 295 +NA+RG V++ L AL S + GA +DV EP D PL +N ++ PHIG Sbjct: 237 VNAARGGVINQKDLYQALVSGAIKGAGLDVTDPEPMAKDD----PLLTLNNCVVLPHIGS 292 Query: 296 STQEAQENIGLEVAGKLIKYSDNGSTLSAV 325 +T E + + ++ D L+ V Sbjct: 293 NTMETRTEMASLAVNNVLAVLDGKPLLTPV 322 >UniRef50_B1ZP48 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=4 Tax=Verrucomicrobia RepID=B1ZP48_OPITP Length = 326 Score = 362 bits (930), Expect = 2e-98, Method: Composition-based stats. Identities = 87/327 (26%), Positives = 138/327 (42%), Gaps = 17/327 (5%) Query: 12 KFLLV----EGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 + LL + + L G+ I G L++ + + +T Sbjct: 3 RILLTTTSFQDTPGGHHDLLAQTGWEVIRAR-GPLNEADTLALVGEVDGYIC-GDDAITR 60 Query: 68 DVINAA-EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 V+ A +L + + IG +++D+ + + GIP+ P N +VAE LL L + Sbjct: 61 QVLEKARPRLKVLSKYGIGVDKIDVKSCTEFGIPLLFTPGVNHTTVAEHTFLLLLALEKN 120 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--N 184 G W + E K +GI+G G IG ++ I A++ GM YD+ + Sbjct: 121 FLFHTDSTRSGGWKRK--TGHELLEKTIGIVGLGRIGKEVAIRAKAFGMTPIGYDVYWDD 178 Query: 185 KLPLGNATQVQ-HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 K + + L ++ SD +SLH P T+ M+ A + MK G L++N +RG + Sbjct: 179 KFAAEHGVKRVNSLDEIFAASDYLSLHTNLTPQTRGMINAAAFAKMKKGVLILNCARGEI 238 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 V+ + AL S + G DV EP PL + NV+ TPHIG T E+ Sbjct: 239 VNTADMVAALKSGQVGGYGTDVLDQEPPAAD----HPLLKLPNVVCTPHIGSRTYESVVR 294 Query: 304 IGLEVAGKLIKYSDNGSTLSAVNFPEV 330 LI+ L+ VN PEV Sbjct: 295 QATAAVTNLIRAMHGEKPLAQVN-PEV 320 >UniRef50_A0LN07 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=2 Tax=Bacteria RepID=A0LN07_SYNFM Length = 317 Score = 361 bits (929), Expect = 2e-98, Method: Composition-based stats. Identities = 94/320 (29%), Positives = 151/320 (47%), Gaps = 12/320 (3%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K K LL E +H + E L + +LD++ L D I +R+ +T + Sbjct: 4 KFKILLYESMHARGTEVLAEKCELV---YATSLDEKNLIAQAADVDGIIIRANGAVTRAL 60 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I +A +L IG +G + +DL A +RG+ V P +NT SVAE +G ++L + + Sbjct: 61 IESAPRLKVIGRHGVGLDAIDLRCAKERGVKVVFTPTANTESVAEHFVGMAIMLAKMIRT 120 Query: 130 ANAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDI--ENK 185 + G W + E GK LG++G+G IG Q + M V +YD+ Sbjct: 121 GDIALRTGDWAARNRLIGTELHGKALGVLGFGRIGRQTARICRNGFAMNVIYYDVCDYPA 180 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 + + ++ SD +S+++P PST++ + AK I LMKP + LIN +RG V + Sbjct: 181 VEKELQAKRVSGEEVFEQSDFISVNLPLLPSTRHFVNAKLIRLMKPTAFLINMARGPVWN 240 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 + AL K +AG DV+ EP P PL + DN + TPH+ ++EA + Sbjct: 241 EEDVAGALREKRIAGVGSDVYEVEPV----PADHPLLKMDNFVGTPHMSAHSEEAMIRMS 296 Query: 306 LEVAGKLIKYSDNGSTLSAV 325 VA ++ + V Sbjct: 297 -LVASDVVAVLEGREPEYPV 315 >UniRef50_Q3KHS7 2-ketogluconate reductase n=24 Tax=Proteobacteria RepID=Q3KHS7_PSEPF Length = 326 Score = 361 bits (928), Expect = 2e-98, Method: Composition-based stats. Identities = 93/330 (28%), Positives = 144/330 (43%), Gaps = 13/330 (3%) Query: 8 KDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 K L + +E L+ + K + Q E++ AH + R L + Sbjct: 2 PMKKTVLAFSRITPPMIERLQQDFDVIVPNPKNGDINAQFNEALPHAHGLIGVGR-KLGK 60 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 + A KL + +G + DL +RGI + N P T S A+L ++ R V Sbjct: 61 AQLENAAKLEVVSSVSVGYDNYDLAYFNERGIMLTNTPDVLTESTADLAFALIMSSARRV 120 Query: 128 PEANAKAHRGVWNKL---AAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYF--YD 181 E +A G W + GK LGI+G G+IG + M + + Sbjct: 121 AELDAWTKAGQWQASVGAPLFGCDVHGKTLGIVGMGNIGAAVARRGRFGFNMPIIYSGNS 180 Query: 182 IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 + +L Q + L LL +D V L VP + T++++ +E++LMKP ++L+N SRG Sbjct: 181 RKTELEQELGAQFRSLDQLLAEADFVCLVVPLSDKTRHLISHRELALMKPDAILVNISRG 240 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 VVD PAL +AL + + GA +DV+ EP SPL + N + PHIG +T E + Sbjct: 241 PVVDEPALIEALQNNRIRGAGLDVYEKEPLAE-----SPLFQLKNAVTLPHIGSATNETR 295 Query: 302 ENIGLEVAGKLIKYSDNGSTLSAVNFPEVS 331 E + L VN P+V Sbjct: 296 EAMANRALTNLRSALLGERPQDLVN-PQVW 324 >UniRef50_O33116 D-3-phosphoglycerate dehydrogenase n=22 Tax=Actinomycetales RepID=SERA_MYCLE Length = 528 Score = 361 bits (928), Expect = 2e-98, Method: Composition-based stats. Identities = 103/317 (32%), Positives = 160/317 (50%), Gaps = 10/317 (3%) Query: 13 FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINA 72 L+ + + Q + +L G D +L ++ +A + +RS T + +V+ A Sbjct: 6 VLIADKLAQSTVAAL---GDQVEVRWVDGPDRTKLLAAVPEADALLVRSATTVDAEVLAA 62 Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA 132 A KL + +G + VD+DAA RG+ V NAP SN S AE + LL R + EA+A Sbjct: 63 APKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASRQIAEADA 122 Query: 133 KAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN-- 190 +W + + E GK +G++G G IG + + G +V YD Sbjct: 123 SLRAHIWKRSSFSGTEIFGKTVGVVGLGRIGQLVAARIAAFGAHVIAYDPYVAPARAAQL 182 Query: 191 ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALC 250 ++ DLL +D +S+H+P+ P T ++ + ++ KPG +++NA+RG +VD AL Sbjct: 183 GIELMSFDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEVALA 242 Query: 251 DALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAG 310 DA+ S H+ A +DVF TEP T SPL E V++TPH+G ST EAQ+ G +VA Sbjct: 243 DAVRSGHVRAAGLDVFATEPCT-----DSPLFELSQVVVTPHLGASTAEAQDRAGTDVAE 297 Query: 311 KLIKYSDNGSTLSAVNF 327 + AVN Sbjct: 298 SVRLALAGEFVPDAVNV 314 >UniRef50_A1RDF9 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=1 Tax=Arthrobacter aurescens TC1 RepID=A1RDF9_ARTAT Length = 329 Score = 361 bits (928), Expect = 3e-98, Method: Composition-based stats. Identities = 100/322 (31%), Positives = 162/322 (50%), Gaps = 11/322 (3%) Query: 13 FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINA 72 + + +H+ L +R ++ + ++ + E+I + LR+ T T ++I A Sbjct: 4 IYISDVIHEDVLADIRKNAIVHVGYGPDKVNYLDISENI---DGVILRAET-FTREMIEA 59 Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA 132 + +L I +GT+ VD+ AA++ + V + P SN+ +VAE V LL L R + A Sbjct: 60 SPRLKIIARHGVGTDNVDIPAASEHSVWVTSTPGSNSNAVAEHVFSLLLSLTRRIIPAAN 119 Query: 133 KAHRGVWN--KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 + G W + FE G+ LGI+G+G IG ++ +A GM V D Sbjct: 120 RVLAGTWAEGRGDLVGFELSGRTLGIVGFGAIGKRVATIANGFGMRVLASDPIATAADAE 179 Query: 191 ATQ--VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 A + L L + +D+++LH P T++M+ +E+++MKP +++IN SRG ++D A Sbjct: 180 AAGAVLVELDTLYDGADIITLHAPLLSGTRHMISPRELAMMKPSAIIINTSRGGLIDEDA 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTS---PLCEFDNVLLTPHIGGSTQEAQENIG 305 L AL + LAGAA+DV E DP T PL E N+L+TPHI G TQEA + G Sbjct: 240 LVTALTNGTLAGAALDVLEAESIDMKDPLTHNSVPLHEVPNLLVTPHIAGQTQEAFQEAG 299 Query: 306 LEVAGKLIKYSDNGSTLSAVNF 327 ++ + VN Sbjct: 300 TRSWSEVRAVLAGTTPAFPVNA 321 >UniRef50_C0BYY9 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM 15053 RepID=C0BYY9_9CLOT Length = 330 Score = 361 bits (927), Expect = 4e-98, Method: Composition-based stats. Identities = 100/326 (30%), Positives = 154/326 (47%), Gaps = 16/326 (4%) Query: 10 KI-KFLLVE----GVHQKALESLRAAGYTNIEFHK--GALDDEQLKESIRDAHFIGLRSR 62 K+ K L+ + A E L + G+ + +QL E + + + Sbjct: 6 KMGKILITASHYHELCADARELLESRGHELMINESALPYYTFQQLAEVVGNIDAAVV-GL 64 Query: 63 THLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLL 122 TE+V A +L I F +GT+ +D D A + GI V NAP N+ +VAEL +G ++ Sbjct: 65 DEWTEEVFRMAPRLKVIAKFGVGTDNIDCDTAKEYGIKVINAPGQNSNAVAELTVGFMIQ 124 Query: 123 LLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI 182 LLR + +G W + E +GK +G+ G+G + + S V D+ Sbjct: 125 LLRNILPLYEGIRQGQWVR--YIGGELKGKTVGLFGFGAVAKLVAKKLSSFETEVIACDL 182 Query: 183 ENKLPLGNA--TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 + +++ SD++S+H+P +T +++ IS MK G+ +IN +R Sbjct: 183 HPDSEYAKKYNVGLVSAEEVVERSDILSVHLPATSATYHLVDKAMISKMKRGACMINCAR 242 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G VVD AL +AL S +LAGAA+D F TEP P S L DNV+ TPH G T EA Sbjct: 243 GAVVDTEALTEALKSGYLAGAALDAFETEPL----PADSLLLTCDNVICTPHTGAETYEA 298 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVN 326 N+ L A ++ + L VN Sbjct: 299 YRNVSLCTAQGILDVLEGREPLYWVN 324 >UniRef50_C3XIZ9 D-3-phosphoglycerate dehydrogenase n=4 Tax=Campylobacterales RepID=C3XIZ9_9HELI Length = 535 Score = 360 bits (926), Expect = 4e-98, Method: Composition-based stats. Identities = 107/351 (30%), Positives = 177/351 (50%), Gaps = 15/351 (4%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K ++ + +H + L+ L ++E L ++L + A + RS T + E + Sbjct: 2 KKHIIVCDHIHDEGLKILSTQDDISMENL-AHLPKDELLTHLHKADVLITRSSTGVNEKL 60 Query: 70 INAA----EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 + +A +KL AI +G + VD+DA + RG+ V N P +NT + EL + LL +R Sbjct: 61 LESAYKDSKKLKAIVRAGVGVDNVDIDACSYRGVVVMNVPTANTIAAVELTMTHLLSAIR 120 Query: 126 GVPEANAKAH-RGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE- 183 P A+ + W + E + KKLG+IG+G+IG+++GI A++ M V YD Sbjct: 121 RFPSAHTQLKVERKWKREDWYGIELKDKKLGVIGFGNIGSRVGIRAKAFDMQVIAYDPYI 180 Query: 184 -NKLPLGNATQVQH-LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 L + D+L D++++H P+N T NM+ +KEI+ MK G +LIN +RG Sbjct: 181 NPNKALDLGIEYTTNFDDILA-CDIITIHTPKNKQTTNMITSKEIAKMKDGVILINCARG 239 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 + + L + L SK +A A +DVF +EPAT + L + DN+ +TPHIG +T E+Q Sbjct: 240 GLYNENDLYEGLKSKKIAWAGLDVFDSEPAT-----NNKLLDLDNIYVTPHIGANTLESQ 294 Query: 302 ENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLT 352 E I +E A I + + +A+N P + + + Sbjct: 295 EKIAIEAAHAAISAARGSAFPNALNLPTKTQDMPDSIIAYLELTQKLAYFA 345 Score = 45.0 bits (106), Expect = 0.005, Method: Composition-based stats. Identities = 21/87 (24%), Positives = 38/87 (43%), Gaps = 3/87 (3%) Query: 323 SAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGY--VV 380 + +N + L +G ++ + + PGV+ ++ A+ VNIA L + Sbjct: 446 NNINGFGMDLEPNGNM-ILVRNTDVPGVIGSIGHTIAKHKVNIADFRLGRKTDSSERNAL 504 Query: 381 IDIEADEDVAEKALQAMKAIPGTIRAR 407 I D V+ + L +KAIP + R Sbjct: 505 ALILVDSAVSTQLLDDLKAIPECLSVR 531 >UniRef50_D1CGN8 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CGN8_THET1 Length = 319 Score = 360 bits (925), Expect = 6e-98, Method: Composition-based stats. Identities = 108/326 (33%), Positives = 153/326 (46%), Gaps = 17/326 (5%) Query: 7 EKDKIKFLL----VEGVHQKALESLRAAGYTNIEFH-KGALDDEQLKESIRDAHFIGLRS 61 + + + L+ + L AG + A +E+L E + + I Sbjct: 3 AERRWRVLIGSRSFGQADPSHIRQLEEAGCEVVPNSLGRAYREEELLELLPEMDAII-TG 61 Query: 62 RTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELL 121 LT VI AA +L I +G + +DL+AA +RGI V P + SVA+L +G ++ Sbjct: 62 TDELTARVIEAAGRLRTIAKHGVGLDNIDLEAARRRGIVVTATPGAIHDSVADLTMGLII 121 Query: 122 LLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD 181 + R + A+ G W E R K LGIIG G IG + + A GM V YD Sbjct: 122 AVARQIVPAHNSTVAGEWR--NFVGLELRDKTLGIIGLGRIGKGVCLRALPFGMRVVAYD 179 Query: 182 IENKLP--LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINAS 239 + + + L +LL SDVV+LH + ++G +EI LMKPG++ IN S Sbjct: 180 LYPDEEFARAHGVRFVGLEELLATSDVVTLHASAGNDGR-LLGRREIGLMKPGAIFINTS 238 Query: 240 RGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQE 299 RG +VD ALC+ALA LAGA +DVF EP PL E NV+LTPHI G T+E Sbjct: 239 RGKLVDEGALCEALAVGRLAGAGLDVFEEEPPRG------PLLELPNVVLTPHIAGQTRE 292 Query: 300 AQENIGLEVAGKLIKYSDNGSTLSAV 325 +G ++ L V Sbjct: 293 GMIRMGEMTVQNCLRALRGEEPLYRV 318 >UniRef50_B1R2D5 Glycerate dehydrogenase n=6 Tax=Clostridiales RepID=B1R2D5_CLOBU Length = 314 Score = 360 bits (924), Expect = 7e-98, Method: Composition-based stats. Identities = 105/314 (33%), Positives = 154/314 (49%), Gaps = 13/314 (4%) Query: 11 IKFLLVEGVHQKALESL----RAAGY--TNIEFHKGALDDEQLKESIRDAHFIGLRSRTH 64 +K ++E + + + L + G + D E L E +DA I + S Sbjct: 1 MKLSILEPLGVEKEKFLNMAEKVLGDRVEITYYDNRVEDSETLIERSKDAE-IVVLSNFQ 59 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 +DVI L I G + VD+D RGI V N +T +VA+LV G L+ + Sbjct: 60 YRKDVIEKCPNLKMICVAFTGVDHVDIDYCKDRGITVCNCAGYSTVAVADLVFGLLINIY 119 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 R + E N +G K FE GKK G+IG G IG ++ +A++ G VY Y Sbjct: 120 RNIVECNIVTRKGG-TKNGLVGFELEGKKFGVIGTGAIGMRVANIAKAFGCEVYAYSRTV 178 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 K + L+ LL+ DV+SLHVP N +TK ++ + I LMK ++LIN +RG VV Sbjct: 179 KEGKE--IKYVDLNTLLSTCDVISLHVPLNENTKGLINEENIKLMKKSAVLINTARGPVV 236 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL DAL + +AGA IDVF EP P L + N+++TPH+ +T+E+ Sbjct: 237 DSKALSDALKNNIIAGAGIDVFEIEPPI---PVDHVLFDAPNLIVTPHVAFATKESMVKR 293 Query: 305 GLEVAGKLIKYSDN 318 V + KY + Sbjct: 294 AEIVFDNIDKYING 307 >UniRef50_A1R7L8 D-3-phosphoglycerate dehydrogenase n=35 Tax=Actinobacteria (class) RepID=A1R7L8_ARTAT Length = 539 Score = 360 bits (924), Expect = 8e-98, Method: Composition-based stats. Identities = 118/378 (31%), Positives = 173/378 (45%), Gaps = 17/378 (4%) Query: 9 DKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 K LL E + +E+L D QL +I D I +RS T + + Sbjct: 12 SKPVVLLAEELSPATVEALGPDFEI---RQTDGADRSQLLSAIADVDAILVRSATQVDAE 68 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 I AA+ L I +G + VD+ +A + G+ V NAP SN S AEL +G +L L R +P Sbjct: 69 AIAAAKNLKVIARAGVGLDNVDIKSATQAGVMVVNAPTSNIVSAAELTVGHILSLARHIP 128 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL 188 +A++ G W + E KK+GIIG G IG + + + YD Sbjct: 129 QASSALKNGEWKRSKYTGIELFEKKIGIIGLGRIGALVAARLQGFETEILAYDPYITAAR 188 Query: 189 GN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 ++ L +LL SD +++H+P+ P T M+GA MK + +IN +RG +VD Sbjct: 189 AAQLGVKLVTLDELLENSDFITIHMPKTPETVGMLGADAFRKMKESAYVINVARGGLVDE 248 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL AL +AGA +DVF EP P EFDNV++TPH+G ST EAQE G+ Sbjct: 249 EALYTALKEGQIAGAGVDVFVKEP-----STDLPFFEFDNVVVTPHLGASTDEAQEKAGV 303 Query: 307 EVAGKLIKYSDNGSTLSAVN------FPEVSLPLHGGRRLM-HIHENRPGVLTALNKIFA 359 VA + AVN P+V + +L LT ++ A Sbjct: 304 SVAKSVRLALAGELVPDAVNVAGGVIAPDVRPGIPLIEKLGRIFTALTHASLTQIDVEVA 363 Query: 360 EQGVNIAAQYLQTSAQMG 377 + + + L+ +A G Sbjct: 364 GEIAALDVKVLELAALKG 381 Score = 43.4 bits (102), Expect = 0.015, Method: Composition-based stats. Identities = 21/83 (25%), Positives = 39/83 (46%), Gaps = 1/83 (1%) Query: 325 VNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIE 384 VN +V +P+ ++ + +RPGV+ + I +NI + + G V+ + Sbjct: 452 VNGYDVEIPI-SEHLVVVAYADRPGVIGTIGHILGMNNINIGGMQVARQTEGGQVLALLT 510 Query: 385 ADEDVAEKALQAMKAIPGTIRAR 407 D V ++ L+A+KA G R Sbjct: 511 IDSSVPQQVLEAIKAGIGAEMVR 533 >UniRef50_C7H045 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7H045_9FIRM Length = 388 Score = 359 bits (923), Expect = 9e-98, Method: Composition-based stats. Identities = 108/415 (26%), Positives = 173/415 (41%), Gaps = 45/415 (10%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K + L E +DA + +RS + Sbjct: 2 HKVSTFNKISSVGLSRFTDDYTIV-------------AEDAKDAEGLIVRSYDLHD---M 45 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 + + L I G N + +D K+GI VFNAP +N +V ELVI +LL R +PEA Sbjct: 46 DFDDSLRCIARAGAGVNNIPVDECTKKGIVVFNAPGANANAVKELVIAGMLLAARNIPEA 105 Query: 131 NAKA----------HRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 + K E RGK LG+ G G IG Q+ AE LGM V Y Sbjct: 106 LKWVNTLEMTDDVAKKIEKGKGQFAGTELRGKTLGVFGLGAIGVQVANAAEKLGMKVIGY 165 Query: 181 DIENKLPLGNATQ-----VQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLL 235 D + V + L D +SLH+P TK M+ + +S +K G+ L Sbjct: 166 DPYMTVNSAVKLTRKIKLVTSIEGALPECDYISLHIPAIDETKGMVNQEFLSKVKEGATL 225 Query: 236 INASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGG 295 +N +R ++D AL AL S L D T+ L + V+ PH+G Sbjct: 226 LNFARDKLIDDDALIYALKSGKLKKYITD-----------FTTAKLFGKEGVISIPHLGA 274 Query: 296 STQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSL-PLHGGRRLMHIHENRPGVLTAL 354 S+ EA+EN +++ Y +NG+ +++VNFP SL R+ I+ N G+L+ + Sbjct: 275 SSAEAEENCATMAVVEMMDYLENGNIVNSVNFPNCSLGEKDEAARISIINSNVSGMLSKI 334 Query: 355 NKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 + G+N+ ++ Y +++++ D V + +++ I R++ Sbjct: 335 TGALGDVGINVENLINKSKGDYAYTLLEVKKD--VDPEIIKSSLNFDNIISVRVI 387 >UniRef50_D2RN56 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RN56_ACIFE Length = 319 Score = 359 bits (923), Expect = 9e-98, Method: Composition-based stats. Identities = 98/322 (30%), Positives = 150/322 (46%), Gaps = 11/322 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + A E L GY + A D+ L ++I D + R T+ V++ Sbjct: 3 KILVPKALKPVAREFLTKKGYELV--SPEATDEASLAKAIADVDAVIAR-TEKYTKTVVD 59 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A + L I + IG +DL A + + V A NT SVAE I +L R +P+ N Sbjct: 60 AGKNLKIIARYGIGYENIDLAACDAKNVTVTLARGCNTYSVAEHAISLMLACFRQIPQLN 119 Query: 132 AKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIE-NKLPL 188 + +G W + A + EAR K G IG G IG + +A M + YD ++ Sbjct: 120 QEVRKGNWKSRDAIETHEARYKTFGSIGIGPIGLEAVKIAHFGFQMRILVYDKFVDRSQF 179 Query: 189 GNATQVQH-LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + + L +L+ +DVVS H+P N T +++ + IS MKP ++L+N SRG + D Sbjct: 180 PDWVEFVDTLDELMEQADVVSPHLPLNKGTFHIIDEEAISHMKPTAVLLNVSRGAIWDEK 239 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 A+ AL +A A DVF TEP T PL N + PH T+EA + + + Sbjct: 240 AVYKALKEGRIAAAGADVFETEPPTPDM----PLFSLPNYIGCPHTAALTEEAVDAVAMN 295 Query: 308 VAGKLIKYSDNGSTLSAVNFPE 329 A + + +N PE Sbjct: 296 CAQAIDDLLNGREPKFIINHPE 317 >UniRef50_B0K1J9 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=16 Tax=Bacteria RepID=B0K1J9_THEPX Length = 320 Score = 359 bits (923), Expect = 9e-98, Method: Composition-based stats. Identities = 96/321 (29%), Positives = 152/321 (47%), Gaps = 15/321 (4%) Query: 10 KIKFLLV----EGVHQKALESLRAAGYTNIEFHKG-ALDDEQLKESIRDAHFIGLRSRTH 64 + K L+ E L+ Y I+ G ++ QL + I+D I + Sbjct: 2 RKKILITPRSFGKSSNLPFEMLKKYDYEIIKNESGQPYEESQLIDLIKDVDGIIV-GLDK 60 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 +T +V+ A+KL I + +G + +D+D A + GI + P +N SVA+LV +L L Sbjct: 61 ITSNVLRNAKKLKVITKYGVGVDNIDVDEAERMGIKITYTPDANKESVADLVFALMLGLS 120 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 R + + + W K E K +GIIG G IG + A M + YD Sbjct: 121 REIIKLDNIVRNNRWEK--IIGNEIYKKTIGIIGTGAIGRCVAKRATGFDMKILAYDKYP 178 Query: 185 KLPLGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 N + LL SD ++LH+P T + + +E+ +MK + +IN SRG Sbjct: 179 NYEFANSIGMKYVDKKALLEESDFITLHLPLTEETYHFIDEEELKIMKDTAYIINTSRGG 238 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 +++ AL +AL +K +AGAA+DVF EP P S L + DN++LTPH G ST++A + Sbjct: 239 IINENALYNALKNKKIAGAALDVFEIEP-----PIDSKLLKLDNIILTPHCGASTKDATD 293 Query: 303 NIGLEVAGKLIKYSDNGSTLS 323 +G+ LI + Sbjct: 294 RMGIMAVEGLISVLEGMEPKY 314 >UniRef50_A3MTB6 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=4 Tax=Archaea RepID=A3MTB6_PYRCJ Length = 334 Score = 359 bits (923), Expect = 1e-97, Method: Composition-based stats. Identities = 98/334 (29%), Positives = 157/334 (47%), Gaps = 13/334 (3%) Query: 8 KDKIKFLLVEGVHQKALE-----SLRAAG---YTNIEFHKGALDDEQLKESIRDAHFIGL 59 K K +++ + L+ + G + E++ + DA + Sbjct: 1 MAKYKIVVLSPAPEALLKMWATPIAQKYGIAIDEVEVVTFFEPNYEEIGRHVADADVVVG 60 Query: 60 --RSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVI 117 R + + K+ I G + +D++A A+RGIPV N +N SVAE I Sbjct: 61 DYTFRIKIDASLCEKMSKVRLIQQPSTGYDHIDVEACARRGIPVANIGGANAISVAEHTI 120 Query: 118 GELLLLLRGVPEANAKAHRGVWNKLAAGSF--EARGKKLGIIGYGHIGTQLGILAESLGM 175 L+LL+ A+ + G W + + E GK G++G G IG ++ + A +LG Sbjct: 121 MLALMLLKRAVYAHRRLLEGQWTQGELMNVIGEVFGKTWGVLGMGRIGREVAVRAMALGA 180 Query: 176 YVYFYDIENKLPLG-NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSL 234 V +YD+ + + + + LL SD++S+HVP P+T+ M+G +E+ LMKP ++ Sbjct: 181 KVIYYDVVRNEEMEKRGAEYRPFNRLLAESDILSIHVPLTPATRKMIGERELRLMKPTAV 240 Query: 235 LINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIG 294 +IN SRG +VD AL A+ +AGA +DVF EP P E NV++TPHI Sbjct: 241 VINVSRGEIVDEEALAKAVREGWIAGAGVDVFSVEPPPPDHPLIQAAREGYNVVVTPHIA 300 Query: 295 GSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFP 328 G+T EA+ I + K + VN P Sbjct: 301 GATNEARMRIINVSLENVFKVLAGLKPDNVVNMP 334 >UniRef50_C1A4S7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1A4S7_GEMAT Length = 534 Score = 359 bits (923), Expect = 1e-97, Method: Composition-based stats. Identities = 102/320 (31%), Positives = 165/320 (51%), Gaps = 8/320 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + L+ + V Q+ + L A ++ L ++L I + I RS T ++ +++ Sbjct: 2 FRVLVTDEVDQEGVVLLTAEPALQVD-ELPTLPKDELLRRIGEYDAIVGRSATRISAELL 60 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A KL +G +G + ++LD A GI + NAP NT +VAEL G ++ LLR + A Sbjct: 61 KAGGKLKVVGRAGVGVDNIELDVATSLGIAIINAPAGNTVAVAELFFGTVIGLLRQLHTA 120 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 A G W++ E +GK LGI+G G IG+++ A + GM V YD Sbjct: 121 AAAMGDGRWDRAKFMGRELKGKTLGIVGLGRIGSEVAARAHAFGMTVVAYDPYIADERFA 180 Query: 191 ATQVQ---HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 A +V+ L LL ++V++LHVP T+ M+G +E++ + S+++N +RG V++ Sbjct: 181 ALRVRRAPSLDALLAETNVLTLHVPLTDETRGMIGKRELARLPARSVVVNLARGGVIEEA 240 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL AL + L GA +DVF EP SPL N++LTPH+G +T EAQ N+ + Sbjct: 241 ALQAALETDQLRGAVLDVFTVEPLAPD----SPLRNIPNLVLTPHLGANTVEAQRNVSRD 296 Query: 308 VAGKLIKYSDNGSTLSAVNF 327 V + + ++N Sbjct: 297 VCVAVRDALLHNDLSRSINV 316 Score = 44.6 bits (105), Expect = 0.006, Method: Composition-based stats. Identities = 18/71 (25%), Positives = 36/71 (50%) Query: 340 LMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKA 399 L+ + + PGV+ + + E+GVNIA + AQ G + + D V+E+ +A+ Sbjct: 460 LVLTNHDVPGVIGRVGTLLGERGVNIAEYHQARLAQGGDALAAVSVDGTVSEETRKALLE 519 Query: 400 IPGTIRARLLY 410 + A +++ Sbjct: 520 LSDVRSASIVH 530 >UniRef50_A3CQK1 Glyoxylate reductase, NADH-dependent, putative n=10 Tax=Bacteria RepID=A3CQK1_STRSV Length = 318 Score = 358 bits (921), Expect = 1e-97, Method: Composition-based stats. Identities = 84/323 (26%), Positives = 144/323 (44%), Gaps = 14/323 (4%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K K L+ V ++ L L Y + + E + + L + +++ Sbjct: 3 KKKVLVTGIVPKEGLVKLMEK-YDVTYSDGEPFSRDYVLEHLPEYDAWLLMGQ-KGDKEM 60 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I+A + L I +G + VD++ A ++GI V N+P + AE+ LL + + Sbjct: 61 IDAGKNLQIISLNAVGFDHVDIEYAKQKGIVVSNSPQAVRVPTAEMTFALLLAATKRLAF 120 Query: 130 ANAKAHRGVW---NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN-- 184 + G W ++ G LGI G G IG+ + A++ GM V ++D+ Sbjct: 121 YDKIVRTGNWIDPSERRYQGLTLEGATLGIYGMGRIGSTVAGFAKAFGMKVLYHDLYRLP 180 Query: 185 -KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 + DL+ +DV+++H P PST + + MK S LINA+RG + Sbjct: 181 EEREKELGVSYVEFDDLVEKADVITIHAPSLPSTHHKFNKEVFKKMKNRSYLINAARGPI 240 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 V L +AL + +AGA +DVF EP + L DNV++ PH G T E + Sbjct: 241 VSEEDLIEALKTGEIAGAGLDVFEFEP-----EVSEELRALDNVIMAPHAGTGTIEGRRT 295 Query: 304 IGLEVAGKLIKYSDNGSTLSAVN 326 + E A ++ + + + ++ VN Sbjct: 296 LAAEAAANILSFFEG-NPVNVVN 317 >UniRef50_Q7WEA3 Phosphoglycerate dehydrogenase n=1 Tax=Bordetella bronchiseptica RepID=Q7WEA3_BORBR Length = 329 Score = 358 bits (921), Expect = 2e-97, Method: Composition-based stats. Identities = 112/332 (33%), Positives = 160/332 (48%), Gaps = 14/332 (4%) Query: 14 LLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAA 73 ++ + VH + LRAAG T IE LD L++ I A + +R L ++I+ A Sbjct: 5 VIAQPVHPVGPQLLRAAGITVIEPAGPGLDA--LRQVIAGADAVLVR--DQLPAELIDMA 60 Query: 74 EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAK 133 +L I GT+++ + A GIPV P +N RSVAE + +L+ R +A+A Sbjct: 61 PRLCVIANHGTGTDKIAVAHADALGIPVVYTPQANVRSVAEHALMLMLVTARQAVQADAA 120 Query: 134 AHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIENKLPL--- 188 +G W K + GK LG+IG G G L +A +L M + Sbjct: 121 TRKGHWGFKYEQPMYSLYGKTLGVIGLGRTGRLLCEMAAPALNMQALVWSPSLPAGEALP 180 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 A +V L +LL +DVVSLH P P T++ + A ++ MKPG+++IN SRG ++D A Sbjct: 181 PGARRVDTLQELLREADVVSLHRPLRPDTRHTLDAATLACMKPGAIVINTSRGGLIDEAA 240 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L DAL LAGA +DVF TEP P S + N +LTPH+ GSTQEA + Sbjct: 241 LADALREGRLAGAGLDVFETEPL----PAGSRVAGLPNAVLTPHVAGSTQEALHATASQC 296 Query: 309 AGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRL 340 A ++I V P V Sbjct: 297 AEQIIAVLAGRRPPHLV-KPSVWERRRAPVTP 327 >UniRef50_Q8ZXX8 D-3-phosphoglycerate dehydrogenase (SerA) n=1 Tax=Pyrobaculum aerophilum RepID=Q8ZXX8_PYRAE Length = 323 Score = 358 bits (921), Expect = 2e-97, Method: Composition-based stats. Identities = 83/324 (25%), Positives = 148/324 (45%), Gaps = 15/324 (4%) Query: 13 FLLVEG-VHQKALESLRAAGYTNIEFHKGAL------DDEQLKESIRDAHFIGLRSRTHL 65 + + + L G + H G+ E L ++ R + + + Sbjct: 4 IFVSREGFPESMYKKLEEVGRVEVYRHGGSPWSTRGVPKEVLIDAARRCEALVIFIGDVI 63 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 ++V++A EKL + +G + +D++ A ++G+ V + P+ +VA+L +G L+ + R Sbjct: 64 DKEVLDAGEKLKIVSTASVGVDHIDVEYAKRKGVVVAHTPYVLVDAVADLAVGLLIAVTR 123 Query: 126 GVPEANAKAHRGVWNK--LAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE 183 + + G + + RGK+ GI+G G+IG + ++ + V ++ Sbjct: 124 KIALGDRLIRSGAADAVWGSLMGVNLRGKRAGIVGLGNIGVAIARRLKAFDIEVAYWSRR 183 Query: 184 NKLP--LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 K + L LL+ SD + L + P T+ + + +K G+ IN +RG Sbjct: 184 RKPEVEFALGIEYMELDSLLSSSDFIFLTMALTPETRWFFNRERFAKVKRGAYFINVARG 243 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 +VD AL +AL + LAGAA+DVF EP P L DNV+LTPHIG +T E + Sbjct: 244 GLVDTDALIEALEAGVLAGAALDVFDVEPL----PARHKLASMDNVVLTPHIGSATVETR 299 Query: 302 ENIGLEVAGKLIKYSDNGSTLSAV 325 + A ++ + G + AV Sbjct: 300 RRMAELAAENVVSFFRTGRPIYAV 323 >UniRef50_Q0AFR7 D-3-phosphoglycerate dehydrogenase n=22 Tax=Bacteria RepID=Q0AFR7_NITEC Length = 405 Score = 358 bits (920), Expect = 2e-97, Method: Composition-based stats. Identities = 113/423 (26%), Positives = 187/423 (44%), Gaps = 46/423 (10%) Query: 4 VSLEKDKI-KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSR 62 +S + KI K L + + L+ L A + Q+ I D I +RS Sbjct: 1 MSEDIQKICKVLTLNSIASVGLKRLPANIF-------------QISSDISDPDVILVRSH 47 Query: 63 THLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLL 122 ++ ++AIG GTN + ++ + RGIPVFN P +N +V ELV+ +L+ Sbjct: 48 NMHD---MDIPVSVIAIGRAGAGTNNIPVNQMSARGIPVFNTPGANANAVKELVLAGMLM 104 Query: 123 LLRGVPEANAKAHRGVWN-----------KLAAGSFEARGKKLGIIGYGHIGTQLGILAE 171 R + A + K E G+ LG+IG G IG + A Sbjct: 105 ASRNLIPALRFVEALEGDDQSFHLQVEAGKKQFSGLELPGRTLGVIGLGKIGRPVADAAI 164 Query: 172 SLGMYVYFYDIENKLPLG-----NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEI 226 LGM V YD + + + + DL+ S+ +SLHVP N ST++++ I Sbjct: 165 KLGMKVLGYDPKITIDSAWSLSAEVQRANQIEDLVRRSNFISLHVPLNESTRHLINGPLI 224 Query: 227 SLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDN 286 S M+ ++L+N SR +VD A+ + S + D L + Sbjct: 225 SHMQKNTILLNFSRNAIVDEDAVLAGIKSGIIKNYVCD-----------FPDQKLKQQPA 273 Query: 287 VLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHEN 346 V+ PH+G ST EA+EN + +A +++ Y +G+ VNFP+V + R+ + N Sbjct: 274 VITLPHLGASTHEAEENCAMMIADQIMDYIAHGNISYTVNFPDVVMERGTPFRVAVANAN 333 Query: 347 RPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRA 406 P +L ++ A+ G+NI ++ +M Y ++D D V + + A+ I G + Sbjct: 334 VPNLLGQISTRMADIGLNIHNMINKSRGEMAYTLVD--TDRAVPPEIINAIAQITGVLMV 391 Query: 407 RLL 409 R L Sbjct: 392 RYL 394 >UniRef50_Q03YV3 Lactate dehydrogenase related enzyme n=2 Tax=Leuconostoc RepID=Q03YV3_LEUMM Length = 314 Score = 358 bits (920), Expect = 2e-97, Method: Composition-based stats. Identities = 95/315 (30%), Positives = 154/315 (48%), Gaps = 10/315 (3%) Query: 13 FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINA 72 L + + + L AG + D E++K +A + + D+++A Sbjct: 5 VFLPDDIPAVGKKILEEAGLEVV--VGSGRDHEKMKAEGVEASAVLI-GTQKFDADIMDA 61 Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA 132 L I +G + VD+DAA +RGI V N P + + SVAE + ELL + + + + + Sbjct: 62 MPNLKVIARNGVGYDAVDVDAATQRGIYVVNTPKALSGSVAETAVSELLAISKNLYQDSK 121 Query: 133 KAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA 191 H WN + A + GK +GI+G+G IG Q+ + V +D K Sbjct: 122 AIHDDNWNYRKAHPGRDIEGKTVGILGFGRIGQQVAKKLSGFDVKVIAFDPFAKDVP--G 179 Query: 192 TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCD 251 ++ + +D V +H+P P T++ +GA E LMK + LIN +RG+++ L Sbjct: 180 VELVDRETIFKTADYVMVHLPALPETQHSIGADEFKLMKNDAFLINMARGSILVESDLVL 239 Query: 252 ALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGK 311 AL S +AGAA+DVF EP P T+PL +NVLLTPHI +T E + + ++ Sbjct: 240 ALKSGEIAGAALDVFEEEPL----PVTNPLVALENVLLTPHIASNTVETKARMAVDATND 295 Query: 312 LIKYSDNGSTLSAVN 326 +++ + SAVN Sbjct: 296 IVRVLSGKNPESAVN 310 >UniRef50_D1W6S1 4-phosphoerythronate dehydrogenase n=4 Tax=Prevotella RepID=D1W6S1_9BACT Length = 329 Score = 358 bits (919), Expect = 2e-97, Method: Composition-based stats. Identities = 87/330 (26%), Positives = 155/330 (46%), Gaps = 19/330 (5%) Query: 7 EKDKIKFLLVE----GVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSR 62 +K + ++++ + + + G + E++ E +DA + + ++ Sbjct: 8 KKQAVNIVVLDGHCANPGDLSWDGFKELGSLTVYER---TKPEEVVERAKDAQIVLV-NK 63 Query: 63 THLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLL 122 + D+I +L IG G N +D+ AA + G+ V N P +T SVA++V + Sbjct: 64 VSMKADIIAQLPQLKYIGVLATGFNHIDVKAAQEHGVTVCNIPSYSTYSVAQMVFASIFT 123 Query: 123 LLRGVPEANAKAHRGVWNKLAAGSF------EARGKKLGIIGYGHIGTQLGILAESLGMY 176 + V + G W+K + + E GK +GI+G G+IG ++ +A GM Sbjct: 124 ITNRVEHYAQQTREGQWSKRSDFCYWDTPLLELAGKTMGIVGLGNIGMKVARIAREFGME 183 Query: 177 VYFYDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLI 236 VY Y +N + L + Q L L ++SD++SLH P + T+ ++ A + MK G++LI Sbjct: 184 VYAYTSKNSVDLPSGIQKTTLDGLFSVSDILSLHCPLSERTRELIKADNLRKMKHGAILI 243 Query: 237 NASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGS 296 N RG +V+ + AL S LA DV +EP + PL + N +TPHI + Sbjct: 244 NTGRGPLVNEADVAAALESGQLAAYGADVMCSEPPAADN----PLLKQPNAFITPHIAWA 299 Query: 297 TQEAQENIGLEVAGKLIKYSDNGSTLSAVN 326 T EA+ + + + + + + VN Sbjct: 300 TVEARSRLMNIALNNVRCFLEG-AAQNVVN 328 >UniRef50_D2LZ49 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Bacillus cellulosilyticus DSM 2522 RepID=D2LZ49_BACS4 Length = 326 Score = 358 bits (919), Expect = 3e-97, Method: Composition-based stats. Identities = 88/323 (27%), Positives = 141/323 (43%), Gaps = 11/323 (3%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K K + V + +E L+ ++ L D ++++A I + + + Sbjct: 3 KKKIISYMRVDDRVVEQLKQDFDVTCFYNHEYLGDAAFDHALQEADGII-GLALKVNKQL 61 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 + A KL + +G + +D++ KR I N P + A+ + G L+ R +PE Sbjct: 62 LQHAPKLKVVSNVSVGYDNLDIEEMTKRNIMATNTPGVLDDTTADAIFGLLIATARRIPE 121 Query: 130 ANAKAHRGVWN---KLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIENK 185 ++ G WN + + K LGIIG G IG+ + A GM + +++ Sbjct: 122 LDSFVKEGNWNISLQPEQYGLDVHHKTLGIIGLGSIGSAIAKRAHFGFGMNILYHNRSRN 181 Query: 186 LPLGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 N + L++LL SD V L VP TKNM+ A + MK ++ IN SRG Sbjct: 182 KEAENTYSATYCELNELLENSDFVCLMVPATDKTKNMISASQFKSMKSTAIFINGSRGKN 241 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 VD AL DAL + A +DV+ EP + PL N++ PHIG ST E + N Sbjct: 242 VDEAALYDALVDGEIHAAGVDVYKEEPTNKDN----PLLRLHNIVTLPHIGSSTIECEYN 297 Query: 304 IGLEVAGKLIKYSDNGSTLSAVN 326 + A + K + +N Sbjct: 298 MSKLAAENIKKALTGCKPPTLIN 320 >UniRef50_B9XQY4 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=bacterium Ellin514 RepID=B9XQY4_9BACT Length = 334 Score = 358 bits (919), Expect = 3e-97, Method: Composition-based stats. Identities = 95/323 (29%), Positives = 155/323 (47%), Gaps = 15/323 (4%) Query: 12 KFLLV----EGVHQKALESLRAAGYTNIEFH-KGALDDEQLKESIRDAHFIGLRSRTHLT 66 K ++ E V Q A+ L+AAG + G+ E + + I+DA + + Sbjct: 4 KVVITAPPIEKVGQNAVALLKAAGCEVVNSAILGSPGSEDVLKIIKDADAVI-AGVEKYS 62 Query: 67 EDVIN--AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 DV + ++L I + +G + +D+ +A + GI + P SVA+ +G LL L+ Sbjct: 63 ADVFSVPETKRLKLISRWGVGFDAIDVTSATREGILITYTPGMTDESVADYTMGLLLALV 122 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 R + + +G+W + GK LGI+GYG IG + A+ G+ + +D Sbjct: 123 RRIIDGYETMSKGLWQPAW--GHDMNGKTLGILGYGRIGQAVARRAKGFGLELIAHDPHP 180 Query: 185 KLPLGN-ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 + TQ ++LL SD +SLH ST++++G ++ MKP + LINA+RG + Sbjct: 181 PMGTDQFGTQFVSFNELLERSDYLSLHATLTSSTRDLIGEAQLQKMKPSAYLINAARGPL 240 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 V+ AL AL +AGAA+D F EP P P N+LL+PH S++E+ E Sbjct: 241 VNEQALIRALNEGWIAGAALDAFTVEPL----PVDHPFRRTPNLLLSPHQASSSRESGEL 296 Query: 304 IGLEVAGKLIKYSDNGSTLSAVN 326 I L A ++ +N Sbjct: 297 ISLATAQAVLDLMAGKKPKMPLN 319 >UniRef50_B0PHF7 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PHF7_9FIRM Length = 319 Score = 357 bits (918), Expect = 4e-97, Method: Composition-based stats. Identities = 95/323 (29%), Positives = 152/323 (47%), Gaps = 15/323 (4%) Query: 12 KFLLV----EGVHQKALESLRAAGYTNI--EFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 L+ + QKA+ L + G+ I + E+L + + Sbjct: 3 NILITASHFRTLCQKAIHLLESNGHQVILNDHELPYYSFEELAVWAPEIDGAII-GMDQW 61 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 E V A KL + F +G + +DL+AA + G+ V NA N +VAEL + +L LR Sbjct: 62 NEQVFQIAPKLKILARFGVGVDNIDLEAAKRHGVQVVNAAGMNANAVAELAVAMILNCLR 121 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN- 184 G+PE N K G W++ + GK +G++G+G IG ++ + + YD Sbjct: 122 GIPELNRKLTDGQWSRA--VGRDLLGKTVGLLGFGDIGGRVAKKLSGFEVRLLAYDPYPN 179 Query: 185 -KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 + + L +L SD++S+H+P P+T+++M + + MKP S IN +RG + Sbjct: 180 REKAAALGVTLTDLDTVLTQSDILSIHMPSIPATRHVMNRETFAKMKPDSYFINTARGAL 239 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 VD AL DA+A HLAGAA+DV+ EP P +P+ + PH G T+E N Sbjct: 240 VDTQALVDAVAGGHLAGAAVDVYEQEPL----PMGAPILHTPGIQCIPHAGAETRETYSN 295 Query: 304 IGLEVAGKLIKYSDNGSTLSAVN 326 I + A +I + +N Sbjct: 296 ISMMTAQAVIDSLSGKEPKNWLN 318 >UniRef50_Q5WAF3 2-ketogluconate reductase n=2 Tax=Bacteria RepID=Q5WAF3_BACSK Length = 321 Score = 357 bits (917), Expect = 4e-97, Method: Composition-based stats. Identities = 93/324 (28%), Positives = 150/324 (46%), Gaps = 12/324 (3%) Query: 8 KDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 K L + AL + + I L E L + D L Sbjct: 1 MSKPTVFLARSLPDAALNHISQFCHLRIWDESKPLTREALAHELADVDGAMLTGIGA-DT 59 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 +++ A KL I +G + D+ A++ I V N P+ +VA+L+ G +L R + Sbjct: 60 ELVKHASKLKVISTATVGYDGFDVAGLAEQNIYVTNTPYVLDETVADLLFGLILSGARRI 119 Query: 128 PEANAKAHRGVWNKL----AAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDI 182 + + G W K + + + LGI+G G IG ++ A+ GM + +++ Sbjct: 120 APLHEQVKAGNWTKQTTAQSLYGQDVYNQTLGIVGMGRIGEKIVHRAKEGFGMKILYHNR 179 Query: 183 ENKLPLGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 ++ + + L +LL +DVV + VP +TK+++G +E+S MK ++L+N +R Sbjct: 180 SSRPEVEKKYGAKKVELHELLEQADVVVIMVPLTEATKHLIGKEELSKMKETAILVNGAR 239 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G V+D AL +AL K + GAA+DVF EP P PL E DNV LTPHIG +T Sbjct: 240 GAVIDEAALIEALKQKTIFGAALDVFEVEPL----PPGHPLLELDNVTLTPHIGSATAAT 295 Query: 301 QENIGLEVAGKLIKYSDNGSTLSA 324 +E + L A L+ + A Sbjct: 296 REAMALRAAENLVAGALGQKPRDA 319 >UniRef50_B6YUM0 D-isomer specific 2-hydroxyacid dehydrogenase n=9 Tax=Thermococcaceae RepID=B6YUM0_THEON Length = 333 Score = 357 bits (917), Expect = 5e-97, Method: Composition-based stats. Identities = 94/341 (27%), Positives = 152/341 (44%), Gaps = 18/341 (5%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 + K L++ + K LE L+ + + E+LKE I + I + + +V Sbjct: 2 RPKVLVLFKIKSKPLEELKKHADVELLLYP---SVEELKEKIGEFDGIIVSPLNPIPREV 58 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I AEKL I C G + VD+ AA +RGI V + +VAE +G ++ LLR + Sbjct: 59 IERAEKLKVISCHSAGYDHVDVKAATERGIYVTKVSGVLSEAVAEFAVGLMIALLRRIVY 118 Query: 130 ANAKAHRGVWN--KLAAGSF----EARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE 183 + G W ++ F GK +GI+G G IG + ++LG V ++ Sbjct: 119 TDRFIRAGKWESHRVIWSGFKDIETVYGKTVGILGMGAIGKAIARRVKALGTEVVYWSRS 178 Query: 184 NKLPLGNAT--QVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 K + + L ++L +D+V L +P P T +++ + + LM G L+N RG Sbjct: 179 RKKDIEEEVNAKYLSLEEVLKSADIVVLALPATPETYHIINEERLKLM-EGKYLVNIGRG 237 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFD-NVLLTPHIGGSTQEA 300 ++VD AL AL L G A DVF EP T L + +LTPH G ++EA Sbjct: 238 SLVDEEALVKALKEGKLKGYATDVFEREPVTE-----HELFGMEWETVLTPHYAGLSREA 292 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLM 341 E++G L+ VN + + +++ Sbjct: 293 MEDMGFRAVENLLTVLRGEVPGDLVNREVLKVRPIEEVKML 333 >UniRef50_C0C1A5 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM 15053 RepID=C0C1A5_9CLOT Length = 345 Score = 356 bits (916), Expect = 7e-97, Method: Composition-based stats. Identities = 101/345 (29%), Positives = 159/345 (46%), Gaps = 36/345 (10%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHK---GALDDEQLKESIRDAHFIGLRSRTHLTE 67 +K +++ L+ L G + + +E+L E RDA + + S +T Sbjct: 1 MKIFFTAEYNEEELKPLYEVGEVVKDGWALGLPKMPEEELAEKTRDAD-MIITSYDDITR 59 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 VI AE L I C VD+ AA +RGIPV P N+ S AE+ IG +L R + Sbjct: 60 KVIENAEHLKLIACTRATPVNVDMAAAKERGIPVLYTPGRNSDSTAEMTIGLMLSAARKI 119 Query: 128 PEANAKAHRGV--------------------WNKLA------AGSFEARGKKLGIIGYGH 161 P A G W+ A + +GK LGI+GYG Sbjct: 120 PMAYKALKGGEYTGDPSSRKETKEGLKADVIWDMKADAPYMVFKGTQLKGKTLGILGYGS 179 Query: 162 IGTQLGILAESLGMYVYFYDIEN---KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTK 218 IG ++G +A + GM + +D + + + +L+ SD ++ H+ P T Sbjct: 180 IGRRVGRIARAFGMQLLIFDPFVGEVDVEEIGIKKAHSVEELMKESDFITCHMKVTPETT 239 Query: 219 NMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFT 278 ++ + I+LMKP + INASRG ++D AL +AL K +AGAA DV+ +EP P+ Sbjct: 240 GIISRERIALMKPTAYFINASRGAILDEEALIEALKEKRIAGAAFDVYESEPIARDHPYI 299 Query: 279 SPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLS 323 + L DNV++TPHI G+T + N ++ + ++ L Sbjct: 300 TEL---DNVVVTPHIAGATDDVLVNHTKQIVSDIKRFLKGEHLLY 341 >UniRef50_C0QCQ5 GyaR n=2 Tax=Bacteria RepID=C0QCQ5_DESAH Length = 333 Score = 356 bits (915), Expect = 8e-97, Method: Composition-based stats. Identities = 80/320 (25%), Positives = 133/320 (41%), Gaps = 11/320 (3%) Query: 14 LLVEGVHQKALESLRAAG-YTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINA 72 L+ + L+ L AG + + +L E I + + Sbjct: 13 LVTRKFPEVGLKLLELAGFDLTLRSSDRPMAFTELVERSTGHQVILCTVGDGINRAFLEH 72 Query: 73 AEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANA 132 L I F +G + +D+D A + GIPV N P + + A++ G ++ R + + Sbjct: 73 CRHLELISQFAVGFDNIDVDTATRLGIPVANTPDVMSEATADIAFGLMIATARKMFFLHK 132 Query: 133 KAHRGVW---NKLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIENKLPL 188 +G W A E GK LGI G G IG ++ + + GM V ++ Sbjct: 133 TILKGEWGYFEPKANLGMELTGKTLGIFGLGRIGEKMAQRCKNAYGMSVIYHSRNRNRTA 192 Query: 189 GN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 +LL SDV+S+H + T+++ MK ++ IN +RG + Sbjct: 193 EKQLGAVWVSFDELLAQSDVLSVHSVLSDDTRHLFDRTAFERMKSTAIFINTARGAIHQE 252 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 L +AL +K + GA +DV EP + PL D V + PH+G +T EA++ + Sbjct: 253 LDLIEALVAKEIWGAGLDVTDPEPMAADN----PLLSMDTVCVLPHVGSATMEARDAMSR 308 Query: 307 EVAGKLIKYSDNGSTLSAVN 326 A +I++ GS VN Sbjct: 309 LAAENIIEFYTKGSVTHLVN 328 >UniRef50_Q7D366 Putative phosphoglycerate dehydrogenase n=1 Tax=Agrobacterium tumefaciens str. C58 RepID=Q7D366_AGRT5 Length = 317 Score = 356 bits (914), Expect = 9e-97, Method: Composition-based stats. Identities = 95/318 (29%), Positives = 149/318 (46%), Gaps = 14/318 (4%) Query: 13 FLLVE----GVHQKALESLRAAGYTNIEF-HKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 L+ A L A G +E + ++L + D + E Sbjct: 5 VLVTATNYSRYCADAKAMLAAEGIDVVENGFGRPMTFDELSARLGDVDAVI-AGVDTWNE 63 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 V N A +L AI F +G + +D+DAA + GI V NAP N +VAEL +G +L +R + Sbjct: 64 RVFNLAPRLKAIARFGVGVDNIDIDAAHRHGIAVTNAPGGNANAVAELTLGLILSAMRRI 123 Query: 128 PEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK-- 185 P + G W++ E G+++G++G+G+I ++ + V YD Sbjct: 124 PYLHDALRGGAWDR--FVGQELIGRRVGLLGFGNIARKIARKLCGFDVEVIAYDKFPDQV 181 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 ++ + ++L+ SD++ + +P P T+ +M A + MKPGS+ IN +RG +VD Sbjct: 182 AATKLGVRMCEMDEVLSSSDILVMMMPSLPETRRLMDAGRFARMKPGSIFINTARGALVD 241 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL DAL S HL AAIDV+ TEPA + PL ++ TPH T E +IG Sbjct: 242 EKALYDALVSGHLQAAAIDVYETEPALPDN----PLFTLPQIVTTPHTAAETYETYTSIG 297 Query: 306 LEVAGKLIKYSDNGSTLS 323 A +I N + Sbjct: 298 RITAEAVIDVLANRQPRN 315 >UniRef50_C8QAG5 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Pantoea sp. At-9b RepID=C8QAG5_9ENTR Length = 317 Score = 355 bits (913), Expect = 1e-96, Method: Composition-based stats. Identities = 88/323 (27%), Positives = 145/323 (44%), Gaps = 16/323 (4%) Query: 11 IKFLLVEG----VHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLT 66 +K + + +L+ G+ I A L+ + D + + + T + Sbjct: 1 MKVICTSPSFAKYDATPITTLQQQGFELITLPADAPLSA-LEPHLADTVAMIV-AFTDVN 58 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 E++++ A +L + +G + ++LDA RGI V N P +N +VA+ +L R Sbjct: 59 EELLSKAPQLKIVCKHGVGVDNINLDATRARGIYVTNVPDANKHAVADFAFALILNSARQ 118 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IEN 184 + +A + G W + + + GK LGI+G G+IG Q+ + A+ M V +D + Sbjct: 119 LTQAAVETRAGHWPR--IFATDVYGKTLGIVGLGNIGKQVALRAKGFNMRVIAFDFYPDE 176 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 K + + + L SD ++LH P T+N+ A I MK + LIN SRG VV Sbjct: 177 KFAAEHGIEFVSMDQLTAASDFITLHTPLTNETRNLFDAARIKRMKKSAFLINVSRGGVV 236 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 + L AL +AGAA DVF EP PL N + T HI G T A I Sbjct: 237 NEQDLFQALQDNVIAGAAADVFEQEPLAE-----HPLFTLGNFIPTSHIAGYTDGAISAI 291 Query: 305 GLEVAGKLIKYS-DNGSTLSAVN 326 G ++++ ++ +N Sbjct: 292 GERCVTQIVQCIQQGERPVNVMN 314 >UniRef50_Q04DF1 D-3-phosphoglycerate dehydrogenase n=1 Tax=Oenococcus oeni PSU-1 RepID=Q04DF1_OENOB Length = 311 Score = 355 bits (913), Expect = 1e-96, Method: Composition-based stats. Identities = 97/317 (30%), Positives = 155/317 (48%), Gaps = 10/317 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K ++ + + + L + IE E + + +DA I L + Sbjct: 1 MKVVVPKALSKAGKNYLSEHDFELIEAPDDK--QETILKVGKDADGIVLM-TDPFDNQTL 57 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 L I +G + VD A + G+ V P +N +VAE I E+L L + + + Sbjct: 58 TKFTNLKIIARHGVGFDNVDEKFAGEHGVYVTITPMANASTVAETTIAEILDLSKNLTKI 117 Query: 131 NAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 + + +G + KL F+ KK+G++GYG IG Q+ A +LGM V +D K Sbjct: 118 SDEMRQGNFAYKLDHMGFDLSHKKIGVMGYGRIGRQVAEKANALGMDVLIFDPFVKETKI 177 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 ++ L++ SDV++LH+ T + G +E+ +MK + LIN RG +VD AL Sbjct: 178 G--KLVDRDTLISQSDVITLHLAVTDQTIHGFGKRELEMMKKSASLINLGRGALVDEQAL 235 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 DAL +K + GAA+DVF EP P TS + DNVLLTPHI +T+E E + ++ A Sbjct: 236 IDALKTKQINGAALDVFDEEPL----PLTSEFYKLDNVLLTPHIASNTKECMERMAVDSA 291 Query: 310 GKLIKYSDNGSTLSAVN 326 ++++ AVN Sbjct: 292 SEVVRVLSGEKPKWAVN 308 >UniRef50_C4V5E1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Selenomonas flueggei ATCC 43531 RepID=C4V5E1_9FIRM Length = 334 Score = 355 bits (913), Expect = 1e-96, Method: Composition-based stats. Identities = 84/322 (26%), Positives = 141/322 (43%), Gaps = 15/322 (4%) Query: 12 KFLLVE----GVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 K + + + + E L AG T I ++ + + DA + +T Sbjct: 3 KIYVTDYEYDSLAPEEHE-LARAGLTLIPQQCH--TEDDVIRTCADASGLL-NQYAPITR 58 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 VI A L I + +G N VDL+AA + G+ V N P V+ L+ R + Sbjct: 59 RVIEALPHLKVIARYGVGVNTVDLEAATEHGVCVLNVPDYCADEVSNHAFALLMACHRKL 118 Query: 128 PEANAKAHRGVWNKLA-AGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL 186 + + + G W+ G+ LG++G+G I L A + G+ YD Sbjct: 119 APLHTQVNGGGWDYNICKPIHRLAGQTLGLLGFGRIPRLLAEKARAFGLKFAVYDPFVTP 178 Query: 187 P--LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 ++ L ++L SD++S+HVP T++++ +E +MKP ++LIN SRG ++ Sbjct: 179 AIVASYGGKLLTLGEVLQASDMISVHVPLTKETEHLLSHREFDMMKPSTILINTSRGPLI 238 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL AL +A A +DV EP SPL N+++TPH ++EA+ + Sbjct: 239 DEEALYAALTQGKIAAAGLDVTEQEPLAQD----SPLRSLPNIIITPHAAWYSEEAECEL 294 Query: 305 GLEVAGKLIKYSDNGSTLSAVN 326 + A + + VN Sbjct: 295 KTKAARGIADILSGHDLPNIVN 316 >UniRef50_Q6KZ29 Gluconate 2-dehydrogenase n=1 Tax=Picrophilus torridus RepID=Q6KZ29_PICTO Length = 310 Score = 355 bits (913), Expect = 2e-96, Method: Composition-based stats. Identities = 86/320 (26%), Positives = 146/320 (45%), Gaps = 16/320 (5%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ E + + + + I K + L ESI DA I + + ++I+ Sbjct: 3 RVLVTEKIP--FTDYYKDIDF--IYKPKNMDSHQWLMESINDADGILITLSDRIDSEIID 58 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AA+KL I + +G + +D+ A R I + P T S A+ + G ++ + R + Sbjct: 59 AAKKLKVISTYSVGYDHIDVKYALSRNIKIGYTPDVLTESTADFIFGLIICIARRICSGY 118 Query: 132 AKAHRGVWN-KLAA---GSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP 187 W + + GK LGI+G G IG + A M V +Y+ + Sbjct: 119 ETIISNKWEYRWKPDFMLGHDVYGKTLGILGLGRIGHAVMRRASGFDMNVIYYNRTERDV 178 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 G+ L++L + SD + + +P N T+N++ IS MK + +INASRG +V+ Sbjct: 179 NGH----VGLNELFSRSDFIVITLPLNDETRNIVNKDLISKMKKTAYIINASRGHIVNED 234 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 L +AL ++ +AGAA+DVF EP + + DNVLLTPH+ ++ E + ++ Sbjct: 235 DLYNALLNRDIAGAALDVFDNEPVRADN----RFVKLDNVLLTPHMASASYETRRDMANL 290 Query: 308 VAGKLIKYSDNGSTLSAVNF 327 L + VN Sbjct: 291 ALKNLELGLHGLNPEKYVNI 310 >UniRef50_C7TNB9 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=74 Tax=Bacteria RepID=C7TNB9_LACRL Length = 325 Score = 355 bits (912), Expect = 2e-96, Method: Composition-based stats. Identities = 97/326 (29%), Positives = 151/326 (46%), Gaps = 15/326 (4%) Query: 11 IKFLLVEGVH---QKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 IK +L++G +L+ G + D +++ I DA I L +T LT+ Sbjct: 2 IKIVLLDGYALNRDLDWSALKKLGECHFYDRTPVNDTQKILARIGDAE-IVLTHKTPLTK 60 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 +I A L IG G + +D++AA+ RGIPV N P T +VA+ +L + V Sbjct: 61 AIIGKAPNLRYIGVMGDGYDVIDVEAASARGIPVTNVPIYATDAVAQFTFALILEITSHV 120 Query: 128 PEANAKAHRGVWNKLAAGSFE------ARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD 181 N H G W +F GK LG++GYG I ++ +A + M V FYD Sbjct: 121 GLHNRLVHEGRWEASPDFTFWAKKLTLLAGKTLGLVGYGRIAQKVASIAHAFSMKVVFYD 180 Query: 182 IENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 K +Q L +LL +D++SLHV + P T N++ + I M+PG ++IN +RG Sbjct: 181 RRPKTHDNQMSQQVSLKELLTTADIISLHVRQAPETLNLIRRETIEQMRPGVIIINTARG 240 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 +++ L AL +A A +DV EP + PL N +TPHI + E + Sbjct: 241 KLINENDLALALNQGKIAAAGLDVSQQEPIQPDN----PLLTAKNCYITPHIAWAPYETR 296 Query: 302 ENIGLEVAGKLIKYSDNGSTLSAVNF 327 E + L + + + VN Sbjct: 297 EKLLALTIANLTAFLKG-TPQNVVNV 321 >UniRef50_A8MCX1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=6 Tax=Thermoproteaceae RepID=A8MCX1_CALMQ Length = 317 Score = 355 bits (912), Expect = 2e-96, Method: Composition-based stats. Identities = 92/308 (29%), Positives = 158/308 (51%), Gaps = 8/308 (2%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 + L+ + + ++ + L G +K + E+L + + + + +RSRT +T +VI+ Sbjct: 10 RALITDKIDERLINKLSEMGVAV--DYKPGIQHEELLKIVENYDILVVRSRTKVTREVID 67 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 L I +G + +D+D A KRG+ + N+P + T S AEL + +L++ R + Sbjct: 68 RGASLKIIARAGVGLDNIDVDYALKRGLTIVNSPNAATYSAAELTLSLMLIISRNLHLHL 127 Query: 132 AKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN--KLPLG 189 G W+K E RGK LG++G+G IG + A++LGM + D+ + + Sbjct: 128 IDVKNGKWSKGLYHGIELRGKTLGVVGFGRIGRAVANYAKALGMRILATDVVDISRYAEE 187 Query: 190 NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPAL 249 V L++LL+ SDVV+LHV N T +M+ + L+K ++++N SRG V+D AL Sbjct: 188 LGASVVSLTELLSRSDVVTLHVALNKETYHMLNDDRLKLIKDNAIIVNTSRGEVIDTKAL 247 Query: 250 CDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 + L L G +DV EP + L + V++TPHIG T +AQ I E+ Sbjct: 248 LNHLD--RLWGVGLDVLEHEPPRED--WEIKLIQHPKVVVTPHIGAETIDAQGRIVDELV 303 Query: 310 GKLIKYSD 317 + + + Sbjct: 304 FNIQEALE 311 >UniRef50_B2RGZ9 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=8 Tax=Bacteroidales RepID=B2RGZ9_PORG3 Length = 319 Score = 355 bits (912), Expect = 2e-96, Method: Composition-based stats. Identities = 93/322 (28%), Positives = 145/322 (45%), Gaps = 12/322 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + L A E++ E I D + + D+I+ Sbjct: 3 KILVAFNTVSEGFDRLTARHKVVFPPKGRDFTQEEIAERIVDCDVLCSVFDIPIGRDLID 62 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 L I + +G N +D+ AA +GI V N P + A+L + LL R + E + Sbjct: 63 KGRSLKLIANYAVGYNNIDVTYAASKGIVVTNTPRAVIEPTADLALALLLSCTRRIAEWD 122 Query: 132 AKAHRG----VWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN--- 184 R +L GK LGIIG+G+IG + ++ GM V + Sbjct: 123 RLFRRDGEMVERGRLCRLGVNLYGKTLGIIGFGNIGAAVARRCKAFGMNVLYNKRTRLSE 182 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 DL+ +DV+SLH P P TK+++G E+S+MKP ++LIN +RG VV Sbjct: 183 AEEKAQGITFADKDDLIRRADVLSLHTPLTPETKHLIGTAELSMMKPTAILINTARGAVV 242 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL +AL K +A A +DVF +D + L DNV LTPH+G T +++ + Sbjct: 243 DERALVEALREKRIAAAGLDVFEN-----NDIPSPELFAMDNVSLTPHVGTQTYDSRVEM 297 Query: 305 GLEVAGKLIKYSDNGSTLSAVN 326 E+ ++ + +S VN Sbjct: 298 VHELCDNVLGFLHGDRPISRVN 319 >UniRef50_Q8CPW2 Glycerate dehydrogenase n=6 Tax=Staphylococcus RepID=Q8CPW2_STAES Length = 323 Score = 355 bits (911), Expect = 2e-96, Method: Composition-based stats. Identities = 74/320 (23%), Positives = 129/320 (40%), Gaps = 10/320 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHK-GALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K L+ + Q +E L+ G + H + E ++ DA + H+ E+V Sbjct: 3 KILVTRQIPQHYVEQLKKIGQVVMWEHDLTPMSRESFLANVEDATACVITLSEHIDEEVF 62 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A++L I +G + +D+ A K G+ V N P T + AEL +L + R + EA Sbjct: 63 LRAQQLKVIANMAVGFDNIDISLAKKHGVVVTNTPHVLTETTAELGFTLMLTVARRIIEA 122 Query: 131 NAKAHRGVWNKLAAG---SFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK-- 185 + G W + G +GI G G IG + + +++ + Sbjct: 123 TSYIQEGKWKSWGPYLLSGKDVYGATVGIFGMGDIGKAFARRLQGFDARIIYHNRKRDLN 182 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 LL SD + P T+N A+ + MK ++ IN RG +VD Sbjct: 183 AERDLNATYVTFKSLLEQSDFIICTAPLTKETENQFDARAFNKMKNDAVFINIGRGAIVD 242 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL +AL + + +DV EP P+ + N ++ PHIG ++Q + + Sbjct: 243 EEALLEALKNHEIQACGLDVMRQEPIQP----NHPILKLPNAVVLPHIGSASQVTRNRMV 298 Query: 306 LEVAGKLIKYSDNGSTLSAV 325 + +N + ++ V Sbjct: 299 QLCIDNIKAVLNNDAPITPV 318 >UniRef50_Q65WI5 SerA protein n=1 Tax=Mannheimia succiniciproducens MBEL55E RepID=Q65WI5_MANSM Length = 326 Score = 354 bits (910), Expect = 3e-96, Method: Composition-based stats. Identities = 93/331 (28%), Positives = 158/331 (47%), Gaps = 11/331 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K ++ +H ++ L A + G + + + + DA + +R + + + + Sbjct: 3 MKVVISHRLHDNGMKVLEDANAQVAITNDG--NPKIMLPELLDAEGLIIRIGS-IDRETM 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A+ L IG +G + VD+ A + GIPV AP SNTRSVAE + + + + Sbjct: 60 LQAKNLKVIGRPGVGVDDVDVKTATELGIPVVIAPGSNTRSVAEHAFALMFACAKDIVRS 119 Query: 131 NAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL--- 186 + + +G + + + ++E K L +IGYG IG+ L +++++GM V YD K Sbjct: 120 DNEMRKGNFAIRSSYKAYELNHKTLALIGYGRIGSILAQMSKAIGMNVKVYDPFVKQGTI 179 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 L D++ S V+S+HVP T+N++G E SLM ++LIN +RG V+D Sbjct: 180 EQEGYIYCTELDDVIRDSHVISIHVPLTNETRNLIGEHEFSLMNEHTILINCARGEVIDE 239 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 P L L + A +DVF EP SPL + DNV+++PH+ G T+EA + Sbjct: 240 PVLTKVLQEGKIHSAGLDVFACEPVD----INSPLFQLDNVIVSPHMAGQTKEAASGVAT 295 Query: 307 EVAGKLIKYSDNGSTLSAVNFPEVSLPLHGG 337 A ++ + N + P Sbjct: 296 MAAEGVVAVINGEKWPYVCNPEAYNHPRWNK 326 >UniRef50_B2T8V2 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Burkholderia phytofirmans PsJN RepID=B2T8V2_BURPP Length = 327 Score = 354 bits (910), Expect = 3e-96, Method: Composition-based stats. Identities = 98/333 (29%), Positives = 155/333 (46%), Gaps = 12/333 (3%) Query: 8 KDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 +K + L +H AL L + + +E L++ + DA + +R L + Sbjct: 2 PEKFRVLATSPIHLSALPILEPSCELVVAPDD---SEETLRKFVADADALIVR--VRLPD 56 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 D+ + A +L A +G + + ++ A + I V N P SNT++VAE V+G +L + RG Sbjct: 57 DIFDHAPRLKACVRHGVGLDFIPVERATRADIAVANLPDSNTQAVAEHVVGAILAMARGF 116 Query: 128 PEANAKAHRGVW-NKLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIENK 185 W + E R + +GI+G G IG Q+ GM V D + Sbjct: 117 DRLPRAWRNDGWLVRQTFQGIELRDRTVGIVGLGRIGLQVAAALHHGFGMRVLGCDNGAR 176 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 L + + ++ + SD ++LH P ST++++ A+ +SL KPG+LL+NA+RG ++D Sbjct: 177 EGLPSYVDQTSIENVFSGSDFITLHAPLVKSTRHLVNAELLSLAKPGALLVNAARGGLID 236 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL AL S + AA+DVF EP P P DNVLLTPH+ T E + Sbjct: 237 DDALVAALRSGQIGCAALDVFEPEPL----PPDHPYWSIDNVLLTPHVAAFTSEGLVRMS 292 Query: 306 LEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGR 338 A +++ VN EV R Sbjct: 293 TGAARAVVEILHGRRPEHLVNE-EVWPRYLERR 324 >UniRef50_A4YUP8 Putative D-3-phosphoglycerate dehydrogenase (PGDH) n=4 Tax=Proteobacteria RepID=A4YUP8_BRASO Length = 335 Score = 354 bits (910), Expect = 3e-96, Method: Composition-based stats. Identities = 104/324 (32%), Positives = 167/324 (51%), Gaps = 13/324 (4%) Query: 10 KIKFLLVEG-VHQKALESLRAAGYTNIEFHKGALDDEQLKESIR--DAHFIGLRSRTHLT 66 + K L+ + +A G ++ + A ++L E I +R + Sbjct: 11 RYKLLITGPALTAEATAIAARRGAALVDNPRYA-SPQELAEITAREQPDGIIVRQG-KID 68 Query: 67 EDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 + VI A++KL AI +G + +D++AA +RGIPVF A +N++SVAEL + + R Sbjct: 69 DQVIGASQKLKAIAKHGVGYDNIDVEAADRRGIPVFVARGANSQSVAELAFALMFAVARE 128 Query: 127 VPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL 186 +P +A+ G W+K + G+ LG+IG+G IG L L + L M V +D Sbjct: 129 IPHLDARIKTGHWDKATTKGAQLLGRSLGVIGFGEIGRILVGLVQPLHMEVRIFDPYMPA 188 Query: 187 PLG--NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 A + L ++L SDV+SLH P P T+NM+G +++ M+ ++LIN +RG ++ Sbjct: 189 DAEISGAERAGSLDEILTASDVISLHCPLMPQTRNMIGRDQLARMRRNAILINTARGGLI 248 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL DAL +AGA +D F EPA PL NV++TPH G STQEA++ + Sbjct: 249 DEAALYDALRDGVIAGAGLDSFAEEPAKPDL----PLLALSNVVVTPHAGASTQEARDAM 304 Query: 305 GLEVAGKLIKYSDNGST--LSAVN 326 G+ ++ + + + VN Sbjct: 305 GVIAVNHVMDVLEGKTFDRRALVN 328 >UniRef50_C1SG57 Lactate dehydrogenase-like oxidoreductase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SG57_9BACT Length = 314 Score = 354 bits (909), Expect = 4e-96, Method: Composition-based stats. Identities = 72/321 (22%), Positives = 128/321 (39%), Gaps = 12/321 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+ + L+ G+ L ++L + DA I + +++ Sbjct: 1 MKILITAELPFDIEGYLK--GHELDYNKGKQLSAKELAKRAEDADGIISMLSDKIDRELM 58 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 + + L + + +G N +D+ AA++ GI V N P T++ AEL ++ R V E Sbjct: 59 ESCKNLKVVANYAVGYNNIDVQAASELGITVCNTPDVLTQTTAELGFALMITAARRVSEG 118 Query: 131 NAKAHRGV---WNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP 187 +A W + GK LG+ G+G IG + +A M + + K Sbjct: 119 DAFTRNKKFKGWEADLFLGMDMHGKTLGVFGFGRIGQAVAQMASGFNMDIIYSSRTKKHQ 178 Query: 188 LGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 DL+ SD + + P P T + + MK ++L+N RG ++ Sbjct: 179 AELLTGASRVSFDDLVRQSDFLIITAPSTPETHHKFTLETFVQMKSSAVLVNIGRGDIIK 238 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 L AL +K + A +DV+ EP + L + N +L PHIG + +E + Sbjct: 239 ERDLVKALENKLIFAAGLDVYEDEPK-----IDAGLFKLSNAVLAPHIGSGSFATREAMA 293 Query: 306 LEVAGKLIKYSDNGSTLSAVN 326 + + A+N Sbjct: 294 KMCCDAVTSVFKDEKPACALN 314 >UniRef50_Q8EMM3 Dehydrogenase n=5 Tax=Bacteria RepID=Q8EMM3_OCEIH Length = 329 Score = 354 bits (909), Expect = 4e-96, Method: Composition-based stats. Identities = 90/328 (27%), Positives = 154/328 (46%), Gaps = 17/328 (5%) Query: 11 IKFLLVEGVH---QKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 K L+ + H E+ + A + +E L + + + +T Sbjct: 4 KKVLITDCDHGNVDVESETFKKA--EISFDLEQCKTEEDLISKGKGFE-VFINQYAPVTR 60 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 VI L + + +G + VD+ AA + G+ V N P VA+ + +L R + Sbjct: 61 SVIENLPDLKLVVRYGVGVDNVDIAAATEHGVQVCNVPDYGMNEVADQALAMMLNFTRSI 120 Query: 128 PEANAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI---- 182 N+ +GVW+ + + + + +G+IG G IG+ +SLG V YD Sbjct: 121 SRMNSFVRKGVWDYQKSMPLYRHSEQTVGVIGVGRIGSSFAKKVKSLGCRVVAYDPKYLD 180 Query: 183 -ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 + K + L++LL +DVVS+H P + + +N++ KE+ MKP + LIN SRG Sbjct: 181 EKAKKSPDFIDEFLPLNELLEQADVVSIHCPLDKA-RNLIDEKELQKMKPTAYLINVSRG 239 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 +++ AL AL ++ +AGAA+DV EP S L E DN + TPH+G +++A Sbjct: 240 GIINEQALNKALTNQWIAGAAVDVAENEPLQPE----SALLEHDNFICTPHMGWYSEQAA 295 Query: 302 ENIGLEVAGKLIKYSDNGSTLSAVNFPE 329 + +VA + I++ + +NF E Sbjct: 296 LELKRKVAEESIRHLNGDQVHYPINFKE 323 >UniRef50_C0DAP4 Putative uncharacterized protein n=3 Tax=Clostridium RepID=C0DAP4_9CLOT Length = 320 Score = 353 bits (908), Expect = 5e-96, Method: Composition-based stats. Identities = 79/322 (24%), Positives = 138/322 (42%), Gaps = 13/322 (4%) Query: 11 IKFLLVE---GVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 ++ ++ + + AG+ +++ L ++DA I + Sbjct: 1 MRVVITDYQYDNVDAERRLVEGAGFELLDYQVK--TPGALIPLVKDADAII-TQYADIDR 57 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 VI + E I + IG N +D AA ++GI V N P V++ + +L L + + Sbjct: 58 QVIESLEHCKMIIKYGIGVNNIDCRAAGEKGIYVCNVPDYGVHEVSDQAVTMILCLGKKL 117 Query: 128 PEANAKAHRGVWNKLAAGSF-EARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKL 186 RG W K G+IG+G I + ++ GM + YD Sbjct: 118 EPLQEDLRRGKWGYGGIVPVKRFTECKAGLIGFGRIPQMVCRKLQAFGMEILVYDPFVDD 177 Query: 187 PLGNATQVQ--HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + A + ++ +D +S+H P T++M+G KE ++MKP ++N +RG VV Sbjct: 178 AVIEAAGAVRASVEEICRNADFISVHCPLTEETRHMIGEKEFAMMKPECCIVNTARGGVV 237 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL AL +AGA +DVF EP + PL +NV+ TPH ++ A + Sbjct: 238 DEQALIGALNEGRIAGAGVDVFEEEPVS----VYHPLLHMENVIATPHSAWYSETAITTL 293 Query: 305 GLEVAGKLIKYSDNGSTLSAVN 326 + A +++ ++ VN Sbjct: 294 QRKAAEEVVNVLQGNEPMNCVN 315 >UniRef50_Q031D4 D-3-phosphoglycerate dehydrogenase n=9 Tax=Streptococcaceae RepID=Q031D4_LACLS Length = 398 Score = 353 bits (908), Expect = 6e-96, Method: Composition-based stats. Identities = 104/373 (27%), Positives = 169/373 (45%), Gaps = 31/373 (8%) Query: 54 AHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVA 113 A R++ + +++L+AIG G N + ++ A +GI VFNAP N +V Sbjct: 34 ADAFICRAQPFHDYEF---SKELLAIGRAGAGFNNIPIEKCASKGIVVFNAPGGNANAVK 90 Query: 114 ELVIGELLLLLRGVPEANAKA--HRGVWN---------KLAAGSFEARGKKLGIIGYGHI 162 ELV+ ++ R + AN +G K A E GK LG+IG G+I Sbjct: 91 ELVLSMMIFGTRNLKPANKWLTGQKGNDKAIDVAVENGKKAFSGSEISGKTLGVIGLGNI 150 Query: 163 GTQLGILAESLGMYVYFYDIENKLPLG-----NATQVQHLSDLLNMSDVVSLHVPENPST 217 G+++ A+ LGM V YD + + +V LS++ +D +++H P T Sbjct: 151 GSKVANDAQRLGMKVIGYDPYLSIEHAWNLSHHVKRVNDLSEIFEKADYITVHTPATDET 210 Query: 218 KNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPF 277 K M+ K +S K G +L+N +R + D A+ A+ + D F +E Sbjct: 211 KGMLNWKNLSKCKNGVILLNYARDEISDKEAILKAIDEGIVRFFGTD-FGSE-------- 261 Query: 278 TSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGG 337 V LTPH+GGST EA N + Y G +++VNFP V L+ Sbjct: 262 --KFYHHPQVFLTPHLGGSTAEASLNCTRMALDSVQTYLKTGEIINSVNFPRVLQELNTP 319 Query: 338 RRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIE-ADEDVAEKALQA 396 R+ I++N P V+ ++ AE+ +NIA + Y ++D++ DE + Sbjct: 320 YRVTLINKNVPNVVAQISIAVAEENINIANIVNRGQGDFAYTLLDLDEKDERKLAALVSR 379 Query: 397 MKAIPGTIRARLL 409 +A +R RL+ Sbjct: 380 FEASENIVRVRLI 392 >UniRef50_A5VTC2 D-isomer specific 2-hydroxyacid dehydrogenases family protein n=153 Tax=cellular organisms RepID=A5VTC2_BRUO2 Length = 360 Score = 353 bits (907), Expect = 7e-96, Method: Composition-based stats. Identities = 88/329 (26%), Positives = 153/329 (46%), Gaps = 12/329 (3%) Query: 7 EKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLT 66 K K +L + +R + + ++ ++++A + + Sbjct: 29 NKKKPMVVLTRKLPDPVETRMRELFDARLNIDDHRMSQPEIIAALKEADVLVPCITDVID 88 Query: 67 EDVINAA-EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 VI A L I F G + +D+ AAA+RGI V N P T A++ + LL + R Sbjct: 89 AAVIEQAGPNLKLIANFGNGVDNIDVAAAARRGITVTNTPNVLTEDTADMTLALLLSVPR 148 Query: 126 GVPEANAKA--HRGVWNKLAAG---SFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 + E G W + GK+LGI+G G IGT + A++ G+ ++++ Sbjct: 149 RLVEGANVINERHGQWPGWSPTWMLGRRIWGKRLGIVGMGRIGTAVARRAKAFGLSIHYH 208 Query: 181 DIENK----LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLI 236 + + AT L +L D++S++ P P+T +++ A+ I+LM+P + L+ Sbjct: 209 NRKRVSPQVEEELEATYWDSLDQMLARMDIISVNCPSTPATFHLLSARHIALMQPTAYLV 268 Query: 237 NASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGS 296 N +RG ++D AL D + LAGA +DVF EPA +P L E V+L PH+G + Sbjct: 269 NTARGQIIDENALIDLIEEGRLAGAGLDVFEHEPAV--NPRLLALAEKGKVVLLPHMGSA 326 Query: 297 TQEAQENIGLEVAGKLIKYSDNGSTLSAV 325 T E + ++G +V + + D + V Sbjct: 327 TIEGRIDMGDKVIINIRAFVDGHRSPDRV 355 >UniRef50_A7VWU5 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753 RepID=A7VWU5_9CLOT Length = 321 Score = 353 bits (907), Expect = 7e-96, Method: Composition-based stats. Identities = 98/325 (30%), Positives = 152/325 (46%), Gaps = 14/325 (4%) Query: 10 KIKFLLVEGVH----QKALESLRAAGYTNIEFH-KGALDDEQLKESIRDAHFIGLRSRTH 64 K K L ++ + A E L G+ IE+ + +++K +D + Sbjct: 2 KKKVLSTVTLYSQRCKSAKELLEKEGFEVIEYQGDTVMTADEIKAVGKDICGAII-GCDE 60 Query: 65 LTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 E++ A L AIG F +G N +DL+AA + G+ V A N SVAE I +L L Sbjct: 61 WNEEIFQACPNLKAIGRFGVGYNNIDLEAAKRHGVKVSIATGINADSVAENTILLVLASL 120 Query: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLG-MYVYFYDIE 183 R + + RG W + + R K G++G+G I + L ++ G + YD Sbjct: 121 RDLVNLDNAVRRGEWVRDS-TGRIIRNKVYGLVGFGAIARYVAKLVKAFGPARIIAYDKY 179 Query: 184 NKLPLGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 ++ ++ SD++S+HVP P T M G KE MK ++ +N +RG Sbjct: 180 PNYEEAEKLGVEIVDFDTVVKESDIISVHVPATPETYKMFGEKEFKAMKDSAVFVNVARG 239 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQ 301 +VVD A+ AL K +A AA DVF EP P +PL E DN+++ PH+ G T E Sbjct: 240 SVVDEAAMYKALKEKWIARAATDVFEEEP----TPKDNPLFELDNIVMMPHMCGDTWETF 295 Query: 302 ENIGLEVAGKLIKYSDNGSTLSAVN 326 E +GL A +I + + +N Sbjct: 296 EAVGLFSAQVIIDVMNGKDPKNWIN 320 >UniRef50_UPI0001973600 D-3-phosphoglycerate dehydrogenase n=1 Tax=Clostridium sp. M62/1 RepID=UPI0001973600 Length = 314 Score = 353 bits (906), Expect = 8e-96, Method: Composition-based stats. Identities = 104/313 (33%), Positives = 166/313 (53%), Gaps = 8/313 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 +K L+++ V+ E L H + EQ+ I D + +R + +D++ Sbjct: 1 MKCLIIDKVYAGIAEELGKFMEVKTAEHLPS-SKEQVLAEIGDVDVLIMRVDPKIDKDIL 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA+ L IG +G N +D++ A ++GI +FNAP N +VAEL I ++L + RG A Sbjct: 60 GAAKNLKIIGVCSVGLNHIDMEYAKEKGIQIFNAPGLNANAVAELTISKMLDISRGTMTA 119 Query: 131 NAKAH-RGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189 N + W+K E RGK LG++G+G IG ++G L + GM V YD K Sbjct: 120 NYDVKVKHEWDKYKFVGRELRGKTLGVMGFGRIGRRVGELGRAFGMTVVAYDPFLKPEDF 179 Query: 190 NATQVQHL--SDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + +LL +SD VS+HVP P TK++ AK I+ MK ++++N SRG +V+ Sbjct: 180 EKEHATGMGIDELLKVSDFVSIHVPLTPETKDLFNAKSIAEMKDDAVVLNMSRGGIVNEK 239 Query: 248 ALCDALASKHLAGAAIDVFPTE----PATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 + +AL + + G A DV E T +D F SPL E DN +++PHIG + +A ++ Sbjct: 240 DMYEALKAGKIGGYATDVMENELAGSGLTGNDTFASPLFECDNFIVSPHIGAQSVDASKD 299 Query: 304 IGLEVAGKLIKYS 316 IG+ + K+ + Sbjct: 300 IGIHIIAKVKEAL 312 >UniRef50_B2KCL9 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Elusimicrobium minutum Pei191 RepID=B2KCL9_ELUMP Length = 315 Score = 353 bits (906), Expect = 9e-96, Method: Composition-based stats. Identities = 103/319 (32%), Positives = 163/319 (51%), Gaps = 8/319 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIR--DAHFIGLRSRTHLTED 68 +K L+ + + +E L+ G+ I ALD+ L E+ + A I +RS T + Sbjct: 1 MKILIADKFPKHWVEVLKEKGHEII--LNPALDENTLPEAQKTEQAEIIIVRS-TKVNAS 57 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 I+AA L + G + +D++ A +G+ V N P +N+ +VAEL +G +L L R +P Sbjct: 58 AIDAAPSLKLVIRAGAGYDTIDINHAKTKGVAVCNCPGTNSIAVAELAMGLILSLDRRIP 117 Query: 129 EANAKAHRGVWNKLAA-GSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP 187 + G WNK + G+ LGIIG GHIG ++ A++ G+ + +D K Sbjct: 118 DNIIDLKAGKWNKTEYSKAKGLYGRTLGIIGLGHIGREVAKRAQAFGLKIIAFDPFVK-E 176 Query: 188 LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 A V + DL +D++++HVP TK+ K MKPG+ IN SRG +V Sbjct: 177 SPLAQMVSDVYDLAKKADIITIHVPNTAGTKHFYDEKFFEAMKPGAYFINTSRGGLVKED 236 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL A A K + AA+DV+ EP ++ F P+ N+ T HIG ST++AQ+ + Sbjct: 237 ALIKACAEKGIR-AALDVYEKEPKADAKEFVDPVTSAVNIYGTHHIGASTEQAQDAVAEV 295 Query: 308 VAGKLIKYSDNGSTLSAVN 326 + + +D G+ L VN Sbjct: 296 AVQIVQELADKGTFLHQVN 314 >UniRef50_UPI0001B4E409 glyoxylate reductase n=2 Tax=Streptomyces RepID=UPI0001B4E409 Length = 333 Score = 353 bits (906), Expect = 1e-95, Method: Composition-based stats. Identities = 82/319 (25%), Positives = 137/319 (42%), Gaps = 9/319 (2%) Query: 12 KFLLVEG-VHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 + L + L+ L A G + +L A I + ++ Sbjct: 4 RVLTTRPDLPGGGLDRLAAQSELVRWDGDGKPEPAELHALAAGASGILCLGNDRVDAALL 63 Query: 71 NAA-EKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 +AA L +G +G + VD +AAA+RG+ V + P + A+L +L+ R + Sbjct: 64 DAAGPSLKVVGLASMGFDGVDREAAAERGVVVTHTPGVLAETTADLTFSLILMARRRLGA 123 Query: 130 ANAKAHRGVWN---KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE-NK 185 A G W+ + G LG++G+G IG + A+ GM V +D Sbjct: 124 ARDSLAAGRWDLFRMDDYLGLDIHGATLGLVGFGQIGRAVARRAQGFGMRVLHHDPFAPD 183 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 ++ L LL +DVVSLHVP P T++++GA E++ MK + L++ SRG V+D Sbjct: 184 DTQDPPSKAVDLPTLLAEADVVSLHVPLTPGTRHLIGAAELAAMKSTATLVSTSRGGVID 243 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL A+ + A +DV+ EP SPL V PHIG +T+ + + Sbjct: 244 ENALLHAVREGGIHSAGLDVYEREPMGTD---LSPLVGEPRVATLPHIGSATEATRAAMV 300 Query: 306 LEVAGKLIKYSDNGSTLSA 324 +++ + + Sbjct: 301 DLAVDNILEVLEGRPATTP 319 >UniRef50_A8R8D3 Putative uncharacterized protein n=2 Tax=unclassified Erysipelotrichaceae RepID=A8R8D3_9FIRM Length = 310 Score = 352 bits (904), Expect = 1e-95, Method: Composition-based stats. Identities = 98/317 (30%), Positives = 146/317 (46%), Gaps = 15/317 (4%) Query: 11 IKFLLV----EGVHQKALESLRAAGYTNIEFHKG-ALDDEQLKESIRDAHFIGLRSRTHL 65 +K L+ QK +E +R AG G A E+ K+ +DA I + L Sbjct: 1 MKVLITPRGFAKYGQKEIERMRNAGLEVHYNDTGLAYTHEEFKKLGKDADAIIV-GVDCL 59 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 +++ L + F +GT+ ++LD A I + N+RSVAE V+ + + Sbjct: 60 DAKMMSDCPNLKVVCKFGVGTDNINLDYAKAHNIYIGRCVGGNSRSVAEHVVALMFAEAK 119 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN- 184 + A + W K E GK+LGIIG+G IG L A +GM +Y YD Sbjct: 120 NLYYAINEVKDHKWTK--PTGLEIYGKRLGIIGFGMIGKYLADYANGMGMDIYAYDAFPI 177 Query: 185 --KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 + + +V L ++ D +SLHVP STKNM+ KE MK + +INA+RG Sbjct: 178 SKEEAQKHHVKVASLDEIYAECDYISLHVPLLDSTKNMISTKEFKSMKNSACIINAARGG 237 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 VVD AL +AL + + A DV+ +EP +D L +N LTPH TQEA+ Sbjct: 238 VVDEEALYEALTTGEIRSACFDVYSSEPPKEND----KLLALENFYLTPHTAARTQEAET 293 Query: 303 NIGLEVAGKLIKYSDNG 319 A +++ Sbjct: 294 RTCEISANIVMEQLLGK 310 >UniRef50_UPI00016C0F1F D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016C0F1F Length = 387 Score = 351 bits (903), Expect = 2e-95, Method: Composition-based stats. Identities = 111/414 (26%), Positives = 178/414 (42%), Gaps = 43/414 (10%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 L + + K + L+ + + L I +RS + ++ Sbjct: 2 FNILTLNEISNKGTDKLKNTDFVV--------TPDALA-----PEAIMVRSASMHNMEL- 47 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A L+AI GTN + ++ ++GI VFN P +N +V EL + LLL R + Sbjct: 48 --APNLLAISRAGAGTNNIPIEKCTEQGIVVFNTPGANANAVKELTLAGLLLASREIIAG 105 Query: 131 NAKAHRG----------VWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY 180 K A E GK L + G G IG + A SLG+ V Y Sbjct: 106 TTWTQTLAAEADIAAVVEKGKKAFIGPEISGKTLVVAGLGAIGVLVANAALSLGLKVIGY 165 Query: 181 DIENKLPLG-----NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLL 235 D + V++L + +D ++LHVP STK M +KPG + Sbjct: 166 DPYLSVTSALLINNGVKIVENLDKAIGQADYLTLHVPYQASTKYMFNQAMFEKIKPGCRI 225 Query: 236 INASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGG 295 +N SRG +VD AL AL +A D FPT + L NV+ PH+G Sbjct: 226 LNFSRGELVDNTALIAALDLGIVAKYVTD-FPT----------AELLNLQNVICIPHLGA 274 Query: 296 STQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALN 355 ST E++EN A +L + G ++VNFP P R+ IH+N P ++ + Sbjct: 275 STPESEENCAEMAATELAAFLKYGVIKNSVNFPTCESPYINKPRITLIHKNIPKMVGQVT 334 Query: 356 KIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLL 409 I A++ +NI ++ ++ Y V+D+++ D + + ++ IPG ++ RL+ Sbjct: 335 NILADENLNIDNMINKSRGEIAYTVVDLDSLNDAPK-IISLLEQIPGMVKVRLI 387 >UniRef50_A6ULR7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Sinorhizobium medicae WSM419 RepID=A6ULR7_SINMW Length = 328 Score = 351 bits (903), Expect = 2e-95, Method: Composition-based stats. Identities = 103/330 (31%), Positives = 160/330 (48%), Gaps = 15/330 (4%) Query: 11 IKFLLVEG-VHQKALESLRAAGYTNIEFHKGALDDEQLKESIRD--AHFIGLRSRTHLTE 67 K L+ + L L AG +G + +L ES+R + R+ L Sbjct: 3 PKVLMTAKTLATPGLALLEQAGCAVSFLKEG--TEAELAESLRSTPFDAVISRTLA-LPA 59 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 +I A L I +G N VD+++A +RG+PV A +N +SVAEL +G L + R + Sbjct: 60 MMIETAPALRVISRHGVGYNNVDIESATRRGVPVLIADGANGKSVAELAVGLALSVARKI 119 Query: 128 PEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP 187 +A WN+ A + GK GI+ +G IG ++ + ++ M + +D + Sbjct: 120 TTQDASIRARQWNRSAY-GLQFAGKTAGIVAFGAIGRRVAEILRAMDMRIIAFDPHARDR 178 Query: 188 LGNATQVQ-HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 L +LL SD+VSLH P P T+NM+ A ++ MKPG++LIN +RG ++D Sbjct: 179 STTGVDWTETLDELLQESDLVSLHCPLTPETRNMITAPRLARMKPGAILINTARGGLIDE 238 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL +A+ S HLAGA +D F EP P P +++TPH+GGST A + + + Sbjct: 239 KALAEAVLSGHLAGAGLDTFADEPL----PADHPFLSLPQIVMTPHMGGSTDVALDGVAI 294 Query: 307 EVAGKLIKYSDNGST--LSAVNFPEVSLPL 334 A ++ +G VN P V Sbjct: 295 SAARNVLDVLIDGKVDRRLLVN-PAVLEHR 323 >UniRef50_Q6F7L0 Glycerate dehydrogenase n=3 Tax=Proteobacteria RepID=Q6F7L0_ACIAD Length = 318 Score = 351 bits (903), Expect = 2e-95, Method: Composition-based stats. Identities = 83/291 (28%), Positives = 138/291 (47%), Gaps = 13/291 (4%) Query: 43 DDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVF 102 +Q+ ++D ++ + + + KL I GTN VDL AA +GI V Sbjct: 35 TPDQVIPRLKDVQVAI-TNKVVINAEALTRLPKLKLILVSATGTNNVDLRAAKAQGIVVC 93 Query: 103 NAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSF------EARGKKLGI 156 N T SVA+ + +L L + + +G W + + F E GK LGI Sbjct: 94 NCQGYGTASVAQHTLTLMLALATSLLRYDHAVAQGRWQQASQFCFLDYPIIELSGKTLGI 153 Query: 157 IGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPS 216 +GYG +G ++ LA++ GM + ++ + + + L LL D +SLH P Sbjct: 154 VGYGELGKEVARLAQAFGMKILIANLPQRPKHEDRLE---LEALLPQVDFLSLHCPLTEH 210 Query: 217 TKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDP 276 T++++ A +LMKP + LIN +RG +V AL DAL +AGAA DV EP N +P Sbjct: 211 TQHLIDAHAFALMKPSAFLINCARGGIVHEQALLDALKQGRIAGAATDVLSIEPPKNGNP 270 Query: 277 FTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNF 327 + N+++TPH + ++++ + ++A +S + VN Sbjct: 271 LLDE--KLPNLIITPHSAWGSVQSRQRMVEQLAENAKAFSIGQTIR-QVNA 318 >UniRef50_B2IKB7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=8 Tax=Proteobacteria RepID=B2IKB7_BEII9 Length = 331 Score = 351 bits (903), Expect = 2e-95, Method: Composition-based stats. Identities = 100/331 (30%), Positives = 154/331 (46%), Gaps = 12/331 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 L+ +H+ L+ LR A ++ + E + A I +R++ L E VI+ Sbjct: 3 HILVAGRIHEAGLDILRNASGITLDLVDE-VSTESYAPLVDRADAILIRTQ-PLPESVID 60 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 A+KL + +G + VD++A +R IP+ N+RSVAE + +L + + V + Sbjct: 61 RAQKLKFVSRHGVGYDVVDVEALTRRNIPLAIVGDVNSRSVAEHAMMLMLAVAKRVCVYD 120 Query: 132 AKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 A G W + + + GK L +IG+G IG + +A M + YD Sbjct: 121 AATRAGKWGIRNDLYATDISGKTLLLIGFGRIGRLVASMARGFDMTILAYDPFLDEAAIK 180 Query: 191 ATQV---QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 A + L L +D VSLH+P P ++G E++ MKPG++LIN +RG VVD Sbjct: 181 AAGAIPTRDLEGALRSADFVSLHMPP-PRNGALLGESELASMKPGAILINTARGGVVDEK 239 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 AL AL LAGA +DVF EP P PL + D V+LTPH T+E + + Sbjct: 240 ALAKALTDGRLAGAGLDVFTQEPP----PADHPLLQMDRVILTPHSAVMTRECAARMAVS 295 Query: 308 VAGKLIKYSDNG-STLSAVNFPEVSLPLHGG 337 + ++ Y VN +S P Sbjct: 296 ASRNILDYFAGRLDPSLVVNGEVLSAPARES 326 >UniRef50_A6TL35 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=27 Tax=Bacteria RepID=A6TL35_ALKMQ Length = 743 Score = 351 bits (902), Expect = 3e-95, Method: Composition-based stats. Identities = 98/323 (30%), Positives = 157/323 (48%), Gaps = 11/323 (3%) Query: 8 KDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 K K + + +AL L+ ++ L ++L E ++ I + S T + E Sbjct: 1 MTKPKVYVTRPLPTEALRLLKERCDVEMKRDSENLSKKELLEKLKKYDAILV-SGTKIDE 59 Query: 68 DVINAAE-KLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRG 126 ++ A + K + + +G + +D+DAA K GI V N P + T + A+L G +L R Sbjct: 60 EICEAIQFKCKILANYGVGYDNIDVDAATKYGIYVSNNPNAVTEATADLAWGLILATARR 119 Query: 127 VPEANAKAHRGV--WNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 + E + G W + + GK +GIIG G IGT +G A+ M + + + Sbjct: 120 IVECDQYIRSGQKNWGPINLLGSQVSGKTIGIIGGGRIGTAVGQRAKGFNMNIIYTGPKP 179 Query: 185 KLPLGNAT--QVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 K AT + LL +D VS+HVP STK+++G E+ LMK ++LIN SRG+ Sbjct: 180 KATFEEATGGKYVDKETLLREADFVSIHVPLLSSTKHLIGTDELKLMKDTAILINTSRGS 239 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302 ++D AL AL + + GA +DVF EP D L + V+LTPH+G ST + + Sbjct: 240 LIDEKALVKALHNNEIGGAGLDVFEQEPVVERD-----LLDIKKVVLTPHVGTSTLDTRI 294 Query: 303 NIGLEVAGKLIKYSDNGSTLSAV 325 +G A + D + + V Sbjct: 295 EMGETCARNIFSVLDGKAPPNCV 317 >UniRef50_Q59516 Glycerate dehydrogenase n=35 Tax=Proteobacteria RepID=DHGY_METEA Length = 314 Score = 351 bits (901), Expect = 3e-95, Method: Composition-based stats. Identities = 87/321 (27%), Positives = 146/321 (45%), Gaps = 17/321 (5%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K + ++ A + ++ E++ E ++ A + ++ + D + Sbjct: 3 KKVVFLDRESLDATVR-EFNFPHEYKEYESTWTPEEIVERLQGAEIAMI-NKVPMRADTL 60 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 L I GT+ VD AA +GI V N +V E V+G + L R + Sbjct: 61 KQLPDLKLIAVAATGTDVVDKAAAKAQGITVVNIRNYAFNTVPEHVVGLMFALRRAIVPY 120 Query: 131 NAKAHRGVWNKLAAGSF------EARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 RG WNK + + G LGIIGYG +G + AE+LGM V +D+ Sbjct: 121 ANSVRRGDWNKSKQFCYFDYPIYDIAGSTLGIIGYGALGKSIAKRAEALGMKVLAFDVFP 180 Query: 185 KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVV 244 + + L +L SDV++LHVP P TKNM+GA+++ MK ++LIN +RG +V Sbjct: 181 QD------GLVDLETILTQSDVITLHVPLTPDTKNMIGAEQLKKMKRSAILINTARGGLV 234 Query: 245 DIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENI 304 D AL AL + GA DV EP + + + N+++TPH+ +++EA + + Sbjct: 235 DEAALLQALKDGTIGGAGFDVVAQEPPKDGNILCDA--DLPNLIVTPHVAWASKEAMQIL 292 Query: 305 GLEVAGKLIKYSDNGSTLSAV 325 ++ + + + V Sbjct: 293 ADQLVDNVEAFVAGK-PQNVV 312 >UniRef50_C6VZ76 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Dyadobacter fermentans DSM 18053 RepID=C6VZ76_DYAFD Length = 337 Score = 351 bits (901), Expect = 3e-95, Method: Composition-based stats. Identities = 86/318 (27%), Positives = 143/318 (44%), Gaps = 8/318 (2%) Query: 5 SLEKDK--IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSR 62 S +K + +K L+ + +H E L A + + E +K ++ + +RS+ Sbjct: 22 SYKKSRATMKILIADSMHPSLFEMLEAQKWD--YDYHPQYKREDIKNALPAYDGLMIRSK 79 Query: 63 THLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLL 122 T L +++ A+ L I G + +DL+ A + I VF+A N +VAE +G LL Sbjct: 80 TFLDREMLENAKNLRFIARAGAGLDLIDLNVARELNIEVFHAGTGNRDAVAEHALGMLLA 139 Query: 123 LLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI 182 L + A+ + G+W++ E GK +G+IGYG+ G+ G V YD Sbjct: 140 LFTNILRADQQVRNGIWDREGNRGVELMGKTVGLIGYGNNGSATAKRLSGFGCKVLAYDK 199 Query: 183 ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242 + ++ +D++SLH+P T+ ++ + IS L+N SRG Sbjct: 200 YRDQYGDAFAAESSIEEIQREADIISLHIPLTDITRQLVNDEFISAFAKPFYLLNLSRGE 259 Query: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSP----LCEFDNVLLTPHIGGSTQ 298 VV + A+ AL S + GA +DV E P L D V+LTPHI G T Sbjct: 260 VVQLKAVTSALESGKIKGACLDVLENEKIGKLTPEQQEVFDYLKSSDRVVLTPHIAGWTH 319 Query: 299 EAQENIGLEVAGKLIKYS 316 E+ I + ++ + Sbjct: 320 ESYVRINEVLVEQIRNWL 337 >UniRef50_C0C032 Putative uncharacterized protein n=2 Tax=Firmicutes RepID=C0C032_9CLOT Length = 319 Score = 351 bits (901), Expect = 3e-95, Method: Composition-based stats. Identities = 93/323 (28%), Positives = 152/323 (47%), Gaps = 15/323 (4%) Query: 12 KFLLV----EGVHQKALESLRAAGYTNIEFHK--GALDDEQLKESIRDAHFIGLRSRTHL 65 K L+ E + + A + L +G+ I EQ+ + I D + Sbjct: 3 KILITASHYEELCKGAKQLLEESGHELIINKSDMPYYTYEQIAQVIGDVDGAII-GLDDW 61 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 TE++ A KL I F +GT+ +D A + GI V NAP N+ +VAEL +G ++ +LR Sbjct: 62 TEEIYKIAPKLKVIAKFGVGTDNIDKIKAREYGIKVINAPGQNSNAVAELTVGLMIGVLR 121 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 G+ + K G W + +E +GK +G++G+G I + + G V D+ Sbjct: 122 GLIPLHKKMENGEWVRR--VGYEIKGKTIGLLGFGAIARLVAEKLMNFGAEVIASDLYPD 179 Query: 186 LPLGNA--TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 L + + +++ SD+VS+H+P T ++ +MK G+ LIN +RG++ Sbjct: 180 AELASRCNVTMVSQKEVMTKSDLVSIHIPATGETHHLFDDAAFRMMKKGAYLINCARGSI 239 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 +D ALC AL +AGAA+D F EP + + + NV+ TPH G T EA N Sbjct: 240 IDTGALCRALKDGRIAGAALDAFEAEPLMKD----AEILKCGNVICTPHTGAETYEAYTN 295 Query: 304 IGLEVAGKLIKYSDNGSTLSAVN 326 + + A +I + N Sbjct: 296 VSMCTAQGVIDVLEGREPQFCTN 318 >UniRef50_Q214B1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Rhodopseudomonas palustris BisB18 RepID=Q214B1_RHOPB Length = 336 Score = 351 bits (901), Expect = 4e-95, Method: Composition-based stats. Identities = 96/329 (29%), Positives = 155/329 (47%), Gaps = 12/329 (3%) Query: 2 AKVSLEKDKI--KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGL 59 A + + + + LL + + + E L + GY + +D++ + I + I + Sbjct: 12 AAFQMNGNAMSKRILLPQELMPEGREYLESRGYQLVT--GSGMDEDHVIHDIPECDGIIV 69 Query: 60 RSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGE 119 R + ++ V +AA+KL + G + VDL AA K G+ V NAP +N+ SVAEL + Sbjct: 70 RL-SPMSARVFDAAKKLKVLVRHGSGYDTVDLAAAKKHGVTVLNAPLANSTSVAELALFY 128 Query: 120 LLLLLRGVPEANAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVY 178 +L R + KL E KKLG+IG G+IG+++ +A M V Sbjct: 129 MLHCSRNFRLVQQTMLVDYYKAKLDTPKSEIACKKLGLIGVGNIGSRVAKMARGFDMQVI 188 Query: 179 FYDIENKLPL-GNATQVQ-HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLI 236 +D ++ + D VSLH P P TK + A+++ LMK ++LI Sbjct: 189 GFDPYKTQADMPEGVELTQDFDRIFTDCDFVSLHCPSTPETKGFVNARQLGLMKGSAVLI 248 Query: 237 NASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGS 296 N +RGT+V+ L AL ++ +AGAA+DV EP + + DNV++ PHIG + Sbjct: 249 NTARGTIVNEDDLYGALTNRKIAGAALDVLAVEPFKPD----HRMLKLDNVVVAPHIGAA 304 Query: 297 TQEAQENIGLEVAGKLIKYSDNGSTLSAV 325 T+EA L A + + V Sbjct: 305 TREATHRASLHSAIGIHEVLSGQKPSWPV 333 >UniRef50_A4YFM2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Metallosphaera sedula DSM 5348 RepID=A4YFM2_METS5 Length = 324 Score = 350 bits (900), Expect = 4e-95, Method: Composition-based stats. Identities = 95/316 (30%), Positives = 152/316 (48%), Gaps = 14/316 (4%) Query: 14 LLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAA 73 ++VE + Q+ + L + + ++Q+ +RDA I R + ++ +I Sbjct: 11 VIVEELDQEKVRELNSLAEIV--YFNPYAPEDQIVSLLRDAIAIVDR-KAKISSKIIREL 67 Query: 74 EKLVAIGCFCIGTN--QVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 L I G + +VDL AA +R I + P N+ +VAEL I + L R V Sbjct: 68 RNLKLIARTGAGVDETRVDLKAAKERDIIITYNPGGNSVAVAELTIMLAIALYRKVIPLA 127 Query: 132 AKAHRGVW---NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP- 187 G W E GK GI+G+G+IG ++ L SL V YD Sbjct: 128 LSVKAGKWSELKPKDTMGHELEGKAWGILGFGNIGKRVAQLVTSLNCKVLGYDPYVSSEI 187 Query: 188 -LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + + L +LL+ SD++S+HVP ST++++ ++ + MK ++LIN SRG ++D Sbjct: 188 MEKHGVKSLSLEELLSKSDIISIHVPLTESTRHLINSERLKTMKKTAILINVSRGGIIDD 247 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL ++L + +AGAA+D EP + PL DNV++TPHIGGST EA Sbjct: 248 KALYESLRNGEIAGAALDTPEEEPVKVDN----PLLSLDNVIITPHIGGSTFEASIKNAN 303 Query: 307 EVAGKLIKYSDNGSTL 322 ++I++ L Sbjct: 304 SAVEEVIRFLKGLPPL 319 >UniRef50_A4FIF2 D-3-phosphoglycerate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FIF2_SACEN Length = 316 Score = 350 bits (900), Expect = 4e-95, Method: Composition-based stats. Identities = 109/309 (35%), Positives = 154/309 (49%), Gaps = 11/309 (3%) Query: 18 GVHQKALESLRAAGYTNIEFHK-GALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKL 76 ++ E L AAG + H+ A+ + L + +A + + +T +VI A +L Sbjct: 13 RFSREPWEILEAAGSAAVRPHETRAMPADDLLARVPEADALIV-GMDLVTAEVIEAGPRL 71 Query: 77 VAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHR 136 I +G + +DLDAA RGIPV AP SN+R+VAEL G ++ R + A+ Sbjct: 72 RVIAKHGVGVDNIDLDAARARGIPVVFAPGSNSRAVAELTFGLMIAAARRIAAAHTAVVA 131 Query: 137 GVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL--GNATQV 194 G W K E G+ LG+IG+G IG L A++ GM V YD + Sbjct: 132 GDWPK--LYGPELAGRTLGVIGFGRIGRLLAGYAQAFGMTVVGYDPFLDDGELTERGVRP 189 Query: 195 QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALA 254 S+ L MSD VSLH+P P ++ + + MKPG+ L+NA+RG +VD AL + L Sbjct: 190 VSFSECLAMSDFVSLHLPAEPGRPPLLDQRALRTMKPGACLVNAARGGLVDESALAELLH 249 Query: 255 SKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIK 314 S HL AA D F TEP SPL NVLLTPHIG + EA ++G+ VA + + Sbjct: 250 SGHLGAAACDAFATEPL-----ADSPLRTAPNVLLTPHIGACSHEANRDMGVMVAQDVAR 304 Query: 315 YSDNGSTLS 323 Sbjct: 305 VLRGEQPHH 313 >UniRef50_B6G9P0 Putative uncharacterized protein n=3 Tax=Bacteria RepID=B6G9P0_9ACTN Length = 427 Score = 350 bits (900), Expect = 4e-95, Method: Composition-based stats. Identities = 102/380 (26%), Positives = 177/380 (46%), Gaps = 32/380 (8%) Query: 46 QLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAP 105 + E DA I +RS D+ + AIG G N + ++ A+RG+ VFN+P Sbjct: 63 EFVERAEDADAILMRSTDLHGYDLPEG---IRAIGRCGAGVNNIPIEEYARRGVVVFNSP 119 Query: 106 FSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWN----------KLAAGSFEARGKKLG 155 +N+ +V E+V+ +++ RG+ +A + K A E RGK++G Sbjct: 120 GANSNAVKEIVLAMMIMSSRGIVQAMQWVRANADDPDILTSAEKAKKAFVGREIRGKRIG 179 Query: 156 IIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG-----NATQVQHLSDLLNMSDVVSLH 210 ++G G++G+++ LGM VY YD + +V L DL D ++LH Sbjct: 180 VVGLGNVGSKVANACVELGMDVYGYDPFISVEHAWALNREVQRVGTLEDLCRGCDYLTLH 239 Query: 211 VPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEP 270 VP T M+ ++++L+ PG++LIN +R T++D A+ AL + L+ A D Sbjct: 240 VPSKADTVGMISTEQLALLAPGAVLINFARETIIDEDAVAAALEAGKLSWFACD------ 293 Query: 271 ATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEV 330 T +T H G T+EA+ N +L Y +NG+ +VN+P Sbjct: 294 -----FATPKTVRMPRTFITTHSGAGTEEAEANCADMAISELKDYLENGNIAHSVNYPAC 348 Query: 331 SL-PLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDV 389 S+ R+ +H N P ++ + I A+ N+ +++ + Y + D DE + Sbjct: 349 SMGKARAASRIACLHANVPNMIGQITAILAKDNANVQRMVNESAGENAYTMFD--TDEHL 406 Query: 390 AEKALQAMKAIPGTIRARLL 409 ++A+K IP R R++ Sbjct: 407 DRATIEALKQIPSMYRVRVI 426 >UniRef50_B8J355 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Desulfovibrio RepID=B8J355_DESDA Length = 309 Score = 350 bits (900), Expect = 4e-95, Method: Composition-based stats. Identities = 81/311 (26%), Positives = 142/311 (45%), Gaps = 15/311 (4%) Query: 11 IKFLLV----EGVHQKALESLRAAGYTNIEFHKGA-LDDEQLKESIRDAHFIGLRSRTHL 65 +K L+ + + + L AG + G L +Q++E + + L + Sbjct: 1 MKILVTPRSFGKTNPELFDRLTQAGLEVVRNDTGGILSADQMREKLAGCQGVIL-GVDPM 59 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 + DV+ AA +L AI + +G + +DL+A +RGI V +N+ +VA+ + +L++ R Sbjct: 60 SADVLAAAPELRAIAKYGVGLDNIDLEACKQRGIAVSRTVGANSNAVADYALTLMLMVAR 119 Query: 126 GVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE-- 183 + + W K S + GK LGI+G G IG + A+ GM + +DI Sbjct: 120 KAGLIDRRCREKDWGK--ITSIDLYGKTLGIVGLGAIGRCVVKRAQGFGMKILGHDIAWD 177 Query: 184 NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 + + + +D ++LH T+N + I++MK +++IN +RG + Sbjct: 178 EAWASAEGVERADMDRICREADFITLHTVLTDETRNCISTGRIAMMKKTAVIINTARGGL 237 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 +D AL AL + GA +DVF EP P DN+++ H ST A E Sbjct: 238 IDETALLTALQEGRIYGAGLDVFEQEP-----PADPAWYALDNLVMGSHCSSSTAGATET 292 Query: 304 IGLEVAGKLIK 314 +G L++ Sbjct: 293 MGRMAVDNLLR 303 >UniRef50_C0WBB3 D-isomer specific 2-hydroxyacid dehydrogenase n=1 Tax=Acidaminococcus sp. D21 RepID=C0WBB3_9FIRM Length = 318 Score = 350 bits (900), Expect = 4e-95, Method: Composition-based stats. Identities = 102/321 (31%), Positives = 150/321 (46%), Gaps = 11/321 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K L+ + + + A L GY +E D+E +K++I D + R T VI Sbjct: 3 KILIPKALKESARTFLTDKGYELVELQ--GTDEETMKKAISDVDAVIAR-TEKYTPAVIK 59 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 AA L I + IG ++L+A K+G+ V A NT SVAE I +L LR + + + Sbjct: 60 AARNLKIIARYGIGYENINLEACDKKGVTVTLARGCNTYSVAEHAITLMLAALRQISQLD 119 Query: 132 AKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIENKL-PL 188 + +G W + + EARGK G IG G IG + +A M + YD Sbjct: 120 REVRKGDWKSRDRVETHEARGKVFGSIGIGPIGMEAVKIAHFGFQMKILVYDKFVDQSKF 179 Query: 189 GNATQVQ-HLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIP 247 + + L DL+ SDVVS H+P N T +++ + IS MK G +L+N SRG + D Sbjct: 180 PDWIEFTNTLDDLMERSDVVSPHLPLNKGTFHILNEESISHMKRGGILLNVSRGAIWDEK 239 Query: 248 ALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLE 307 A+ AL + AA DVF TEP T + PL N + TPH ++EA + + Sbjct: 240 AVYQALQEGRIGAAAGDVFETEPPTPDN----PLFALPNFIGTPHTAALSEEAVTAVAMN 295 Query: 308 VAGKLIKYSDNGSTLSAVNFP 328 A + L +N P Sbjct: 296 CAHAIDDLFSGKEPLYIINHP 316 >UniRef50_A8IH65 D-isomer specific 2-hydroxyacid dehydrogenase n=3 Tax=Proteobacteria RepID=A8IH65_AZOC5 Length = 325 Score = 350 bits (900), Expect = 4e-95, Method: Composition-based stats. Identities = 102/313 (32%), Positives = 149/313 (47%), Gaps = 9/313 (2%) Query: 13 FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIR--DAHFIGLRSRTHLTEDVI 70 + + + + AG + L + I +R + DV+ Sbjct: 6 VSVGGPLAPEGEALIVKAGGRVVST-APYPARADLIALLASEQPDAIVVRVVEKIDADVM 64 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 A+ +L I GTN +D++AAA G+PV A +N SVAE + LL L + + Sbjct: 65 RASPRLKLIAKHGAGTNDIDVEAAAALGLPVIAAVGANAHSVAEHALALLLALAKDIRTQ 124 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL-- 188 +A G W K FE RG+ LG++G G IG + + LGM V+ YD Sbjct: 125 DAFVRGGGWEKRVYKGFELRGRTLGLVGLGMIGRSFAAMVQPLGMTVFGYDPFAAPEAFG 184 Query: 189 GNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 + +V L D+L DV+SLH P P T+ ++ A+ + LMKPGSLLIN +RG VVD A Sbjct: 185 PHVERVADLDDMLGRCDVISLHCPLTPQTEGLINARALGLMKPGSLLINTARGEVVDEEA 244 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L AL + L GA +D F EP + T PL NV+L+PHIGG T++A+ + Sbjct: 245 LVAALKNGPLGGAGLDSFAHEPPSP----THPLWSLPNVILSPHIGGVTEDARRQVSTMT 300 Query: 309 AGKLIKYSDNGST 321 A + + Sbjct: 301 ATNVAALMTGETI 313 >UniRef50_C7H518 Glycerate dehydrogenase n=3 Tax=cellular organisms RepID=C7H518_9FIRM Length = 320 Score = 350 bits (900), Expect = 4e-95, Method: Composition-based stats. Identities = 91/326 (27%), Positives = 149/326 (45%), Gaps = 17/326 (5%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGA---LDDEQLKESIRDAHFIGLRSRTHLTE 67 +K +++E + + L +G + + E++ I DA + L ++ + E Sbjct: 1 MKAVILESYVMEEGD-LDWSGVKALVPDTVSYVRTAYEEIAPRIGDADIVLL-NKCRMNE 58 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 +++ L +G GT+ +DL+A + G+ V N P +T SVA++ LL + + Sbjct: 59 EILQQCPNLKWVGIIATGTDNLDLEACRRHGVAVANVPGYSTYSVAQMTFSLLLAICQCA 118 Query: 128 PEANAKAHRGVWNKLAAGS------FEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD 181 N +G W S E GK G+ GYG IG Q +A + GM V Sbjct: 119 ERYNRAVKQGCWQLDIPESIGLLPQMELCGKTYGVYGYGSIGRQSARIARAFGMEVLVCT 178 Query: 182 IENKLP-LGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASR 240 + + + LL D++SLH P P T+ ++ A+ ++ MKPG++L+N +R Sbjct: 179 RTVRPEYAADGVEFVDYDTLLRRCDILSLHCPATPQTRGLVNAEALAKMKPGAILLNTAR 238 Query: 241 GTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEA 300 G +VD A+ AL S L D F TEP P SPL + +LTPHI +T+EA Sbjct: 239 GALVDEEAVAAALHSGQLGFYGADAFVTEPL----PQESPLRAEPHAILTPHIAWTTREA 294 Query: 301 QENIGLEVAGKLIKYSDNGSTLSAVN 326 +N+ L + + VN Sbjct: 295 LQNLMDITTRNLRTWLEGNG-EHIVN 319 >UniRef50_Q8EP33 Glycerate dehydrogenase n=2 Tax=Bacillaceae RepID=Q8EP33_OCEIH Length = 314 Score = 350 bits (900), Expect = 5e-95, Method: Composition-based stats. Identities = 95/308 (30%), Positives = 145/308 (47%), Gaps = 11/308 (3%) Query: 21 QKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIG 80 +E+L G I ++ E+LK+++R+ I + + +++I+AA L I Sbjct: 16 PDFVENLNRLGNVTILDTDNGIEKEKLKQAVREVEVII-TAVVQIDKEIIDAAPNLKYIM 74 Query: 81 CFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWN 140 F G + +D A ++GIPV N P N +VA+L IG +L R +P N + G W Sbjct: 75 KFGAGYDNIDFKYAREKGIPVTNTPGQNADAVADLAIGLMLATARNIPAKNEELRNGNWE 134 Query: 141 KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNA--TQVQHLS 198 E KKLGIIG+G IG + A M V Y + + + L+ Sbjct: 135 LS--MGIEIFQKKLGIIGFGAIGQAIAQRATGFQMEVLAYGTFQDQTIADRLNVEFVDLN 192 Query: 199 DLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHL 258 LLN SD+V + ++ AK ++ +K +L IN SRG +VD AL +AL + + Sbjct: 193 KLLNESDIVVVSTTLRKDNYQLINAKTLNEIKKDALFINVSRGALVDEDALYEALTNGKI 252 Query: 259 AGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDN 318 GA +DVF EP PL N +TPHIG +T EA + G + + ++ Sbjct: 253 KGAGLDVFVEEP------SHHPLLTLPNTTVTPHIGAATNEAIKRTGSVALENVQRLKND 306 Query: 319 GSTLSAVN 326 L VN Sbjct: 307 LPLLYVVN 314 >UniRef50_Q6MN05 Phosphoglycerate dehydrogenase n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MN05_BDEBA Length = 328 Score = 350 bits (899), Expect = 5e-95, Method: Composition-based stats. Identities = 93/315 (29%), Positives = 155/315 (49%), Gaps = 12/315 (3%) Query: 10 KIKFLLVEGVHQKALESLRAA--GYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 K K L+ + Q + L+ + L E + AH + +RSRT + E Sbjct: 2 KKKILITDRFAQDSFLYLQQHSQFEVVRSDNPQHLP----LEHLVSAHALIIRSRTKIDE 57 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 +++ A +L I G + +DL+A K G+ V + P +N S A+L G +L + + Sbjct: 58 ELLKKARQLQLIVTCTSGFDHIDLEATQKWGVTVMHTPTANIESAAQLTWGLVLSCVNNI 117 Query: 128 PEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLP 187 A+ G WN+ E G+ GI+G G IG+++ LA++ GM V YD + Sbjct: 118 QAAHKMVKAGEWNRDQITGIELAGRNYGIVGLGRIGSRVAELAQAFGMNVVAYDPYQEDE 177 Query: 188 LGNATQVQHL--SDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 + + L ++L +DV+S HVP+ T++M+ + + G +LIN SRG+V++ Sbjct: 178 VFERLHIPRLSYEEVLKTADVISFHVPKTLETEHMLNRSQFEYIHRGIVLINTSRGSVIN 237 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 LC+AL L +DV+ EP S L ++ N++LTPHIG +T++A Sbjct: 238 ENDLCEALEKGWLRSVGLDVYEKEPLNR----NSNLLKYPNLVLTPHIGANTEDAFFKAS 293 Query: 306 LEVAGKLIKYSDNGS 320 A KL+ + +GS Sbjct: 294 QIAANKLMAFFVDGS 308 >UniRef50_A1W9A3 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=2 Tax=Acidovorax RepID=A1W9A3_ACISJ Length = 339 Score = 350 bits (899), Expect = 6e-95, Method: Composition-based stats. Identities = 93/341 (27%), Positives = 153/341 (44%), Gaps = 23/341 (6%) Query: 7 EKDKIKFLLVE--GVHQKALE-SLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRT 63 E ++ L + Q A++ L A + + + + + +I + + RT Sbjct: 3 EDHRLTVLFTDFAPTDQAAMQQRLPAHWHAHFVQREHLVASDTEDGAI---EVLCVFVRT 59 Query: 64 HLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLL 123 + E V+ +L + G + +DL+A KRGI V + P + SVAE LL + Sbjct: 60 RVDESVLRMLPRLRLVATRSAGFDHIDLEACRKRGIAVCHVPDYGSASVAEHAFALLLGV 119 Query: 124 LRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI- 182 R + +A+ +A +G + FE G+ LGI+G G IG + +A GM V YD Sbjct: 120 TRHLTQAHERARQGSFAYRGLTGFELEGRTLGIVGLGRIGRHVARIAVGFGMDVLAYDPA 179 Query: 183 -ENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRG 241 + +L SD++SLHVP +T++++ A+ + MKPG ++IN +RG Sbjct: 180 FAASAARPAGVSLVTWEQVLQGSDILSLHVPATEATRHLIDARAFARMKPGVVVINTARG 239 Query: 242 TVVDIPALCDALASKHLAGAAIDVFPTE----PATNSD----------PFTSPLCEFDNV 287 ++D AL AL +A A +DV E P + +SPL V Sbjct: 240 ALIDEAALLRALDDGSVAAAGLDVLEQEGALSPEVPTGCGGLGCDTGWMASSPLLTHPRV 299 Query: 288 LLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFP 328 L+TPH+G +T EA I E + + + V+ P Sbjct: 300 LVTPHVGFNTTEAIARIFDETISNIAAWHAGR-LRNRVDEP 339 >UniRef50_A7ZTA0 Glyoxylate/hydroxypyruvate reductase B n=224 Tax=Proteobacteria RepID=GHRB_ECO24 Length = 324 Score = 350 bits (899), Expect = 6e-95, Method: Composition-based stats. Identities = 86/328 (26%), Positives = 133/328 (40%), Gaps = 12/328 (3%) Query: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 K +L + + L+ L+ + + EQ +A + S ++ + Sbjct: 2 KPSVILYKALPDDLLQRLQEHFTVHQVANLSPQTVEQNAAIFAEAEGLL-GSNENVDAAL 60 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 + KL A +G + D+DA R I + + P T +VA+ ++ +L R V E Sbjct: 61 LEKMPKLRATSTISVGYDNFDVDALTARKILLMHTPTVLTETVADTLMALVLSTARRVVE 120 Query: 130 ANAKAHRGVWNKL---AAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIENK 185 + G W + K LGI+G G IG L A M + + + Sbjct: 121 VAERVKAGEWTASIGPDWYGTDVHHKTLGIVGMGRIGMALAQRAHFGFNMPILYNARRHH 180 Query: 186 LPLGNA--TQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 + L LL SD V L +P T ++ GA++ + MK ++ INA RG V Sbjct: 181 KEAEERFNARYCDLDTLLQESDFVCLILPLTDETHHLFGAEQFAKMKSSAIFINAGRGPV 240 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 VD AL AL + A +DVF EP + SPL NV+ PHIG +T E + Sbjct: 241 VDENALIAALQKGEIHAAGLDVFEQEPLS----VDSPLLSMANVVAVPHIGSATHETRYG 296 Query: 304 IGLEVAGKLIKYSDNGSTLSAVNFPEVS 331 + LI + VN P V+ Sbjct: 297 MAACAVDNLIDALQGKVEKNCVN-PHVA 323 >UniRef50_C4TXE2 D-3-phosphoglycerate dehydrogenase n=3 Tax=Bacteria RepID=C4TXE2_YERKR Length = 317 Score = 350 bits (899), Expect = 6e-95, Method: Composition-based stats. Identities = 103/312 (33%), Positives = 147/312 (47%), Gaps = 28/312 (8%) Query: 39 KGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRG 98 + L ++QL +DA F+ + S +T VI A +L I C +D+ AA +RG Sbjct: 10 EPKLSEDQLIALGQDADFL-VTSYDDITARVIKACPQLKLIACTRASPVNIDVKAATERG 68 Query: 99 IPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGV----------------WNKL 142 IPV P N+ + AEL I +L + R +P+A++ +G W+ Sbjct: 69 IPVIYTPGRNSDAAAELTIALMLNVARHIPQAHSALKQGQFTATEQSHFGLKTDVVWDVT 128 Query: 143 A------AGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL--GNATQV 194 E R K LGI+GYG IG ++G +A + GM + D Sbjct: 129 KDSPYEVFKGIELRNKTLGIVGYGSIGQRVGRIARAFGMQLLVADPYVSEVELDEPGIHK 188 Query: 195 QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALA 254 L L + +D VSLH+ P T+ ++ A SLMKP + IN SR VV L DAL Sbjct: 189 STLEQLFSQADFVSLHLKVTPQTEGLIDAHLFSLMKPEAYFINTSRAAVVVEQHLIDALR 248 Query: 255 SKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIK 314 K LAGAA+DV+ EP S PF FDNV++TPHI G+T+E +A + + Sbjct: 249 HKQLAGAALDVYAHEPIHASHPFIHE---FDNVVITPHIAGATRETLVKHTAMIAQDIER 305 Query: 315 YSDNGSTLSAVN 326 + N L N Sbjct: 306 FLRNEPLLYRYN 317 >UniRef50_B2A705 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A705_NATTJ Length = 331 Score = 350 bits (899), Expect = 7e-95, Method: Composition-based stats. Identities = 89/327 (27%), Positives = 143/327 (43%), Gaps = 15/327 (4%) Query: 9 DKIKFLLVEGVHQKALESLRAAGYTNIEFHKGA-LDDEQLKESIRDAHFIGLRSRTHLTE 67 D K + + + L L+ N G + +++L E+ + + +TE Sbjct: 3 DHPKVYVTSNIPEAGLTLLKEKFKLNFHQPLGQQITEDELIEAAKSHDALITTLTDPVTE 62 Query: 68 DVINAAEK---LVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLL 124 V A + L + + G + + +DA + I V N P + A+L ++ + Sbjct: 63 RVAAAGQNGGKLKVVANYGAGYDNIAVDAFSNADIRVTNTPGVLHETTADLTFALIMGIA 122 Query: 125 RGVPEANAKAHRGV---WNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD 181 R + EA G W + + +GIIG G IG + A M V +Y+ Sbjct: 123 RRINEAEKFLRSGQFQGWKPDLLLGEDVHDRTIGIIGMGEIGQAVAKRALGFNMEVIYYN 182 Query: 182 IE---NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINA 238 + Q + L +LL+ SD VS+HVP +T++M+ AKE S MK + LIN Sbjct: 183 RSYLSQEREQELQAQYKSLEELLSESDFVSIHVPLTNNTQHMITAKEFSQMKNSAFLINT 242 Query: 239 SRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQ 298 SRG V+D AL DAL + + GAA+DVF EP + L + + LL PHIG +T Sbjct: 243 SRGPVIDEQALVDALKTGEIQGAALDVFEKEPEVHP-----ELLDRQDCLLVPHIGSATH 297 Query: 299 EAQENIGLEVAGKLIKYSDNGSTLSAV 325 + + N+ + D + V Sbjct: 298 KCRNNMSEMACKNVEAVLDGQEPPTPV 324 >UniRef50_A1W7V5 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=3 Tax=Bacteria RepID=A1W7V5_ACISJ Length = 337 Score = 350 bits (898), Expect = 7e-95, Method: Composition-based stats. Identities = 96/337 (28%), Positives = 149/337 (44%), Gaps = 26/337 (7%) Query: 11 IKFLL--VEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTED 68 +K L+ E +A + L G+ + DE ++ DA I + LT + Sbjct: 1 MKILVVETEEWEHRACQRLLP-GHKLVCRSNALGPDEPTADN--DAEVITPFVHSRLTAE 57 Query: 69 VINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVP 128 V+ +L I G + +DLD GI V N P +VAE LL + R + Sbjct: 58 VLAQFPRLRLIATRSTGYDHIDLDYCRAHGIAVSNVPDYGDATVAEHAFALLLAVSRHIV 117 Query: 129 EANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPL 188 + RG +++ FE RGK LG++G G IG ++ + + GM + YD+ + Sbjct: 118 TGAERTRRGDFSQHGLRGFELRGKTLGVLGTGRIGRRVIEIGKGFGMKIVAYDLFPDAAV 177 Query: 189 GN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + L LL+ +DVV+LHVP P T +++G E + MK G++LIN +RG VVD Sbjct: 178 AEHLGYEYLDLHVLLSQADVVTLHVPATPQTHHLLGDPEFAAMKKGAVLINTARGGVVDT 237 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSD------------------PFTSPLCEFDNVL 288 AL AL+++ L A +DV P EP + L F NV+ Sbjct: 238 SALVRALSARKLRAAGLDVLPAEPLIREEAEIFRNDRRNSDTDLRALLADHVLLRFSNVI 297 Query: 289 LTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAV 325 +TPH+ T EA I + ++ + V Sbjct: 298 VTPHVAYDTDEALRRILDTTIANIEAFARGQ-PRNLV 333 >UniRef50_UPI0001C36DF4 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein n=1 Tax=Ruminococcus flavefaciens FD-1 RepID=UPI0001C36DF4 Length = 316 Score = 349 bits (896), Expect = 1e-94, Method: Composition-based stats. Identities = 80/327 (24%), Positives = 144/327 (44%), Gaps = 22/327 (6%) Query: 11 IKFLLVEGV-----HQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 +K +++ + L G + + +I DA + ++ + Sbjct: 1 MKIAVLDWYTVNNSGDIPVSQLEELGDVRVF---SLTSPGETAANIGDAEIVLC-NKVLI 56 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 T +V++A + IG F G N VD++ AA++GI V NA +T +VA+ +L Sbjct: 57 TREVMDACPDIKYIGLFATGFNNVDIEYAAEKGITVCNAGQYSTNAVAQQTFAYILDHFS 116 Query: 126 GVPEANAKAHRGVWNKLAAGSF------EARGKKLGIIGYGHIGTQLGILAESLGMYVYF 179 + E + G W + A S+ E GK L I+GYG IG ++ + + GM + Sbjct: 117 RIREYDKAVRNGEWERSPAFSYFPVPTSELAGKTLSIVGYGSIGRKVAEIGRAFGMDIVI 176 Query: 180 YDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINAS 239 +V + +DV++ H P T ++ + +S MKP ++L+N + Sbjct: 177 STRTKPADCP--YEVTDMMSAAEKADVLTFHCPLTDKTAGIINKELLSHMKPSAMLVNTA 234 Query: 240 RGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQE 299 RG VV+ L +AL + +A A +DV EP + PL N ++TPH + E Sbjct: 235 RGGVVNEAELAEALKNGTIAAAYLDVLEKEPMSPDT----PLKGLQNCIITPHTAWAPLE 290 Query: 300 AQENIGLEVAGKLIKYSDNGSTLSAVN 326 ++ + V + + +G+ + VN Sbjct: 291 TRQRLVDIVCDNIRAW-QSGAPKNKVN 316 >UniRef50_C0YQP9 Possible glyoxylate reductase n=1 Tax=Chryseobacterium gleum ATCC 35910 RepID=C0YQP9_9FLAO Length = 328 Score = 349 bits (896), Expect = 1e-94, Method: Composition-based stats. Identities = 82/327 (25%), Positives = 142/327 (43%), Gaps = 12/327 (3%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIG-LRSRTHLTEDV 69 +K + + + + ++ L AG I K L E+ ++ I + + ++ Sbjct: 1 MKVFINKRIPEAGIKMLEEAGLEIIFPEKENLSYEEWLNYCKNTDTILSIGTEFTYDKNF 60 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 A + AI + +G + VD A + IP+ N P +R+ +++ + + R Sbjct: 61 FEACPDVKAIALYSVGFDHVDTKEATLKNIPIGNTPDVLSRATSDVAFLLMQSVARRASY 120 Query: 130 ANAKAHRGVW---NKLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMYVYFYDIENK 185 K G W + L A E GK LGI G G IG ++ ++ + GM + +++ + Sbjct: 121 NFGKVKEGSWGAFDPLHALGQELYGKTLGIFGLGRIGYEMAEKSKKAFGMNIIYHNRHHN 180 Query: 186 LPLGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 DL+ SDV+S+H P K + MK ++ IN +RG Sbjct: 181 EEAEKELGATYVSFEDLIRNSDVLSVHANFTPEHKELFNKSLFEQMKSNAIFINTARGGF 240 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 + L AL + + GA +DV EP D P+ + +V + PHIG +T EA+ Sbjct: 241 HNQKDLYQALVDQKIWGAGLDVTNPEPMAADD----PILQLSSVCILPHIGSATVEARNG 296 Query: 304 IGLEVAGKLIKYSDNGSTLSAVNFPEV 330 + AG +I +S+N + N PEV Sbjct: 297 MARLAAGNIIAFSENKKMPNCAN-PEV 322 >UniRef50_B7ALT2 Putative uncharacterized protein n=1 Tax=Bacteroides eggerthii DSM 20697 RepID=B7ALT2_9BACE Length = 318 Score = 349 bits (896), Expect = 1e-94, Method: Composition-based stats. Identities = 92/322 (28%), Positives = 145/322 (45%), Gaps = 13/322 (4%) Query: 11 IK-FLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69 +K L+ + + A E++ Y I KG + L I + +T+++ Sbjct: 1 MKTILVTHQLPKVAFETI-VNDYKIIMPDKGLISSCMLDRWIGRCDALLPTYAFKVTKEI 59 Query: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129 I+ A L I F G + +D++ A +GI V N+P AEL LL + R + E Sbjct: 60 IDRATNLEIIANFGAGYDNIDVNYAITKGILVTNSPKPVIEPTAELAFSLLLNVARRISE 119 Query: 130 ANAKAHRGVW---NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN-- 184 + K + + GK LGI+G G IG L A + GM + +Y+ + Sbjct: 120 CDRKLRSSRGIEIDVMENLGISLYGKTLGIVGMGAIGQALARRASACGMRIIYYNRKRLS 179 Query: 185 -KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTV 243 ++ L++LL SD +SLH P T +M+ ++ LMKP +LIN +RG + Sbjct: 180 QEIENAYEADWVSLNELLATSDFISLHAPATSETYHMIDIQQFKLMKPSVVLINTARGNL 239 Query: 244 VDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQEN 303 ++ L L K + GA +DVF EP S L + DNVLL+PH G T + + Sbjct: 240 INERVLIHFLQKKRIFGAGLDVFENEPEIP-----SELLQLDNVLLSPHNGTGTIDTRVE 294 Query: 304 IGLEVAGKLIKYSDNGSTLSAV 325 +I Y + + LS V Sbjct: 295 STRYALQNIINYFEGKTLLSPV 316 >UniRef50_UPI0001973D95 D-3-phosphoglycerate dehydrogenase n=1 Tax=Clostridium sp. M62/1 RepID=UPI0001973D95 Length = 322 Score = 349 bits (896), Expect = 1e-94, Method: Composition-based stats. Identities = 101/321 (31%), Positives = 161/321 (50%), Gaps = 11/321 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN 71 K +L E L+ N++ ++ E+ + + DA + LR +DVI Sbjct: 3 KVVLAGNYPAHTYERLKTM-LENLDCTLTKVETEEEYQKMTDAEIMVLRI-FKARQDVIE 60 Query: 72 AAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEAN 131 + L I + G + VD++AA K G+ V N P +N +V+EL + +L + R + + Sbjct: 61 RNKGLKMIIRWGAGFDSVDIEAAGKNGVVVANTPGANAPAVSELAVMLMLAVGRHLIDHM 120 Query: 132 AKAHRGVWNKLAA--GSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE---NKL 186 +GVW+K S+ K +GIIG G+IG Q A++ G + +YD + Sbjct: 121 DSLRKGVWSKNTYINQSYTLNRKLVGIIGAGNIGRQTAKKAQAFGAEIQYYDPFRLSPER 180 Query: 187 PLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDI 246 + L LL SDV+SLHVP S ++M+GA+EIS MK G++L+N +RG +VD Sbjct: 181 EQELGLRYVPLETLLKTSDVISLHVPLTDSNRHMIGAEEISQMKDGAILVNTARGGLVDD 240 Query: 247 PALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGL 306 AL +A+ S LAGA +DV EP D L +++TPH+GG T + + I Sbjct: 241 QALAEAVRSGKLAGAGLDVVENEPLKEDDS----LLTTPGIVVTPHVGGGTADIGDEILP 296 Query: 307 EVAGKLIKYSDNGSTLSAVNF 327 +A ++ + + AVN Sbjct: 297 MLAKEIERVINGQMPEHAVNL 317 >UniRef50_B3T034 Putative D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein n=1 Tax=uncultured marine microorganism HF4000_001L24 RepID=B3T034_9ZZZZ Length = 311 Score = 349 bits (896), Expect = 1e-94, Method: Composition-based stats. Identities = 89/317 (28%), Positives = 153/317 (48%), Gaps = 9/317 (2%) Query: 11 IKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K L+ + + + A + + K L +E++ + I D + +RS T +T+++I Sbjct: 2 PKVLISDSMSKVAQKIFEKNKISV--DVKTGLSEEEIIKIIPDYDGMVVRSATKVTKNII 59 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 AA+KL I G + +D+ A + + V N P N + AE + ++ +LR +P A Sbjct: 60 LAAKKLKVIARAGAGVDNIDVPTAKENNMLVMNTPGGNANATAEHALALIMSVLRKIPYA 119 Query: 131 NAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN 190 N H+G W K E K LGI+G+G++G +L L + + + + + Sbjct: 120 NDTTHKGKWEKKNIKGAELSKKTLGIVGFGNVGARLSNLVKGFEVNILVSSKSLESRQKD 179 Query: 191 ATQV--QHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPA 248 V +L++ SD++S H P K ++ + MKP + +IN +RG +VD Sbjct: 180 FPHVKNVSFDELISASDIISFHCKSAPDGKPIINKEHYKKMKPSTFIINTARGNIVDEKD 239 Query: 249 LCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEV 308 L AL +AGAA+DV+ EPA + L V+LTPH+ ST EA + Sbjct: 240 LNAALNGNLIAGAALDVYSKEPAKENI-----LFNNPKVILTPHVAASTAEASIVVAEMA 294 Query: 309 AGKLIKYSDNGSTLSAV 325 A ++ + G+ ++AV Sbjct: 295 ANQISNFLLKGNKINAV 311 >UniRef50_D1CAH7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1CAH7_SPHTD Length = 348 Score = 348 bits (895), Expect = 2e-94, Method: Composition-based stats. Identities = 97/320 (30%), Positives = 145/320 (45%), Gaps = 20/320 (6%) Query: 28 RAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTN 87 A G FH LD++ +A + + + L + +L I G + Sbjct: 27 EALGPLAPVFHSEPLDEDSTH-LAAEAEIVSVFIHSRLDRPTLERLPRLRLIATRSTGYD 85 Query: 88 QVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSF 147 +DL A A+RG+ V N P+ +VAE G +L L R + A + RG ++ F Sbjct: 86 HIDLAACAERGVVVTNVPYYGENTVAEHTFGLILALSRNIHRAYVRTQRGDFSLAGLEGF 145 Query: 148 EARGKKLGIIGYGHIGTQLGILAESLGMYVYFYD--IENKLPLGNATQVQHLSDLLNMSD 205 + +GK LG+IG G IG + +A+ GM V +D LP + L +LL +SD Sbjct: 146 DLKGKTLGVIGTGSIGLHVIRIAKGFGMEVVAHDLRPSRILPEVLGFRYVPLDELLQVSD 205 Query: 206 VVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDV 265 + SLHVP P+T ++M + + MK GSLLIN +RG +VD +L AL LAGA +DV Sbjct: 206 IASLHVPYLPATHHLMNRETFARMKRGSLLINTARGGLVDTESLMWALDEGILAGAGLDV 265 Query: 266 FPTE------------PATNSDPFT----SPLCEFDNVLLTPHIGGSTQEAQENIGLEVA 309 E PA L +NV++TPHI + EA I Sbjct: 266 LEGEELIQEESQLLTQPAVEDKLRAVLRQHLLARRENVVITPHIAFYSTEAVHRIMDVTI 325 Query: 310 GKLIKYSDNGSTLSAVNFPE 329 + + D + + V+ P Sbjct: 326 ENINAFLDG-NPQNVVSAPA 344 >UniRef50_A1AQ02 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=10 Tax=Bacteria RepID=A1AQ02_PELPD Length = 318 Score = 348 bits (894), Expect = 2e-94, Method: Composition-based stats. Identities = 91/305 (29%), Positives = 143/305 (46%), Gaps = 11/305 (3%) Query: 27 LRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAE-KLVAIGCFCIG 85 DE++ + I + L ++I+ + I G Sbjct: 20 FSPLSDLTAFTRYDNSSDEEIPSRVEG-QTIVITKELPLGRELIHCFPASVKLICEAGTG 78 Query: 86 TNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGV---WNKL 142 N +D+ AA RGI V N P +T +VA+L I +L L + + RG + K Sbjct: 79 YNNIDIAAARSRGIGVCNVPSYSTDAVAQLAITFMLNLSASLVQQQTMLRRGNLDNFQKS 138 Query: 143 -AAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLL 201 FE GK LG+IG+G IG ++ +A +LGM + + + L + L +LL Sbjct: 139 LQLPHFELNGKTLGVIGFGEIGRRVIAIARTLGMKIIVHSRTPRPELDPDLRFVSLEELL 198 Query: 202 NMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGA 261 SD VSLH P N +T++++ A+ + +MKP + +IN SRG ++ PAL AL +AGA Sbjct: 199 ATSDFVSLHCPLNDATRHVINAERLEMMKPTAFIINTSRGPLIHEPALSQALTRGTIAGA 258 Query: 262 AIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGST 321 +DV EP D PL +NV+LTPHIG E ++ + A + + + + Sbjct: 259 GLDVQEQEPPEPGD----PLYSLENVILTPHIGWKRLETRQRLIGLTAANIDAFIKDAAI 314 Query: 322 LSAVN 326 + VN Sbjct: 315 -NIVN 318 >UniRef50_A8FRW0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=20 Tax=Bacteria RepID=A8FRW0_SHESH Length = 323 Score = 348 bits (894), Expect = 2e-94, Method: Composition-based stats. Identities = 83/329 (25%), Positives = 142/329 (43%), Gaps = 19/329 (5%) Query: 11 IKFLLVE-------GVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRT 63 + ++++ + + L + G + +L A I ++T Sbjct: 1 MNIVVLDGYTLNPGDLDWQPLVKIAKQGREGQFHCYDRTSEAELISRASGAD-IIFTNKT 59 Query: 64 HLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLL 123 +T + ++ L IG GTN VDL+ A +RG+ V N P +VA++V +L Sbjct: 60 PITAETLSQLPNLKYIGVLATGTNVVDLNCARERGVAVTNVPGYGPDAVAQMVFAHILHH 119 Query: 124 LRGVPEANAKAHRGVWNKLAAGSFEAR------GKKLGIIGYGHIGTQLGILAESLGMYV 177 + V ++ G W F GK LG++GYG IG Q+ +A + GM V Sbjct: 120 TQRVSIHHSAVSEGKWTDCEDFCFTLAPLQSLQGKTLGLMGYGAIGRQVANIALAFGMKV 179 Query: 178 YFYDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLIN 237 L L + ++ D++SLH P +T ++ + M+ ++LIN Sbjct: 180 LVNTRTEPLDLPPGVKWAAFDSMIPRVDILSLHCPLTEATDKIINRTVLEKMRSSAILIN 239 Query: 238 ASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGST 297 +RG ++D AL AL +A A +DV TEP + PL N+ ++PH +T Sbjct: 240 TARGGLIDEAALKQALDEGEIAAAGVDVLSTEPPQADN----PLLNAVNISISPHNSWAT 295 Query: 298 QEAQENIGLEVAGKLIKYSDNGSTLSAVN 326 +EA++N+ G L + + VN Sbjct: 296 REARQNLLNIAIGNLQAFLS-EKPRNRVN 323 >UniRef50_Q49ZM5 Putative 2-hydroxyacid dehydrogenase SSP0606 n=25 Tax=Bacilli RepID=Y606_STAS1 Length = 318 Score = 348 bits (893), Expect = 3e-94, Method: Composition-based stats. Identities = 103/321 (32%), Positives = 155/321 (48%), Gaps = 11/321 (3%) Query: 12 KFLLVEGVHQKALESLRAAGYTN-IEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI 70 K + + + L L+ G+ + G +D E LK+ ++DA + T + ++VI Sbjct: 3 KVYIAGPIPEVGLNLLKDQGFEVDMYEGTGIIDKETLKQGVKDADALISLLSTSVDKEVI 62 Query: 71 NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEA 130 +AA L I + G N VD+D A ++ I V N P ++T S AEL +L + R +PE Sbjct: 63 DAANNLKIITNYGAGFNNVDIDYARQQNIDVTNTPKASTNSTAELTFALVLAVARRIPEG 122 Query: 131 NAKAHR---GVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK-- 185 + W L E GK +GIIG G IG+ + A++ M + + K Sbjct: 123 DKLCRTTGFDGWAPLFFRGREVSGKTIGIIGLGEIGSAVARRAKAFDMNILYTGPHQKVD 182 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 + L LL +D V+++ NPS + + + +MKP S LINASRG +V Sbjct: 183 KEREIGAKYVDLETLLKNADFVTINAAYNPSLHHQIDKAQFEMMKPTSYLINASRGPIVH 242 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL AL K + GAA+DVF EP N L DNV++TPHIG +T E+++ + Sbjct: 243 EKALVQALKDKEIEGAALDVFEFEPEIND-----ELKTLDNVVITPHIGNATFESRDMMS 297 Query: 306 LEVAGKLIKYSDNGSTLSAVN 326 VA I +N VN Sbjct: 298 KIVANDTISKLNNDQPKFIVN 318 >UniRef50_B0JPW3 McyI protein n=6 Tax=Cyanobacteria RepID=B0JPW3_MICAN Length = 337 Score = 348 bits (893), Expect = 3e-94, Method: Composition-based stats. Identities = 102/333 (30%), Positives = 157/333 (47%), Gaps = 12/333 (3%) Query: 4 VSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRT 63 ++++ K + LL+ ++ +A + L LD + E+I++ + +R Sbjct: 9 LTMDIQKHRVLLIGKMYDEAGQKLLEESTNTEILSNPTLDK--INEAIQEVSGVFVRYPN 66 Query: 64 HLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLL 123 L I A++L I GT+ +D+ AA ++G+ V N P +T +VAE + +L L Sbjct: 67 KLEASSIRLAKQLKVISTSGFGTDSIDIMAATEQGVIVVNNPGMSTTAVAEHTLSMILAL 126 Query: 124 LRGVPEANAKAHRGVWN-KLAAGSFEARGKKLGIIGYGHIGTQLGILA-ESLGMYVYFYD 181 + +P + +G + + + K LGI+G G IGT + +LGM V YD Sbjct: 127 AKKLPFLDHCVKKGNYLIRNQMQPIQLENKTLGIVGLGRIGTLVAHKCNLALGMRVLAYD 186 Query: 182 IEN---KLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINA 238 K AT V+ L LL SD VSLH T+ M + MKP + LIN Sbjct: 187 PYVPASKAETVGATWVKDLDVLLAESDFVSLHTELTSETREMFNISVLKKMKPTAFLINT 246 Query: 239 SRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQ 298 SRG VV L AL K +AG A+DVF EP +PL F+NV+L+PH+ G T Sbjct: 247 SRGKVVCEKDLGIALNQKLIAGCALDVFEPEPPA----LDNPLYNFENVILSPHLAGVTP 302 Query: 299 EAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVS 331 EA + A ++++ +N PEV Sbjct: 303 EASLAAAVSAANQILQVLQGEKPPYMIN-PEVW 334 >UniRef50_C3BRQ1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=4 Tax=Bacillales RepID=C3BRQ1_9BACI Length = 341 Score = 348 bits (893), Expect = 3e-94, Method: Composition-based stats. Identities = 97/331 (29%), Positives = 139/331 (41%), Gaps = 11/331 (3%) Query: 1 MAKVSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLR 60 M K E K K + E V + L + E L E I+D H + Sbjct: 14 MKKKGAETVKPKVYIAERVPKFVETYLSEHCEYEKWDSSEKIPREVLLEKIKDKHGLL-N 72 Query: 61 SRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGEL 120 T + E+++ AA L + +G + DL+A R + N P+ +VA+LV + Sbjct: 73 FGTKIDEELLRAAPHLKVVSNISVGYDNFDLEAMQGRNVIGTNTPYVLDDTVADLVFALM 132 Query: 121 LLLLRGVPEANAKAHRGVWN---KLAAGSFEARGKKLGIIGYGHIGTQLGILAE-SLGMY 176 L R V E ++ G WN + +GIIG G IG + A+ M Sbjct: 133 LSAGRRVCELDSYVKDGNWNAEITKKHFGLDVHHSTIGIIGMGRIGEAVAKRAKFGFDMN 192 Query: 177 VYFYDIENKLPLGN--ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSL 234 V +Y+ K L LL SD + L P T ++G KE SLMK ++ Sbjct: 193 VLYYNRRRKEEAEQKFDAAYCDLHTLLKQSDFIVLLTPLTEETYQLIGEKEFSLMKETAI 252 Query: 235 LINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIG 294 INASRG VD PAL DAL K + A ID F EP + PL NV+ PHIG Sbjct: 253 FINASRGKTVDEPALIDALKQKKIFAAGIDTFTQEPVEKDN----PLLSLTNVVTLPHIG 308 Query: 295 GSTQEAQENIGLEVAGKLIKYSDNGSTLSAV 325 +T + + + + A L+ + + V Sbjct: 309 SATLKTRHQMAMTAAENLVAGLQGKTPPNIV 339 >UniRef50_Q1GAM7 D-isomer specific 2-hydroxyacid dehydrogenase n=1 Tax=Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 RepID=Q1GAM7_LACDA Length = 322 Score = 347 bits (892), Expect = 4e-94, Method: Composition-based stats. Identities = 90/327 (27%), Positives = 155/327 (47%), Gaps = 15/327 (4%) Query: 6 LEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHL 65 L+ + K L+ + + L L + F + ++ D + + + Sbjct: 5 LKMENAKVLVAG-LAVRQLPELEKVCE--VTFAPAGAGKDWYLANLGDFDALI-TGKLPV 60 Query: 66 TEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLR 125 +++++A +KL + +G + +D+D A+ +GI V N P S + AE+ LL L R Sbjct: 61 DQELLDAGKKLKIVSATGVGYDHIDVDYASSQGIIVSNCPASVMQPTAEMAFTLLLALSR 120 Query: 126 GVPEANAKAHRGVWNKLAAG---SFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDI 182 + N + + + GK LGI G G IG L A + GM + +++ Sbjct: 121 KLALYNQEMRQENFLDTGLLENQGQSPVGKTLGIFGMGRIGKTLASYARTFGMNILYHNR 180 Query: 183 E---NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINAS 239 L+DLL+ +D VSL+ P T +++ +S+M+P + LIN S Sbjct: 181 HQLPEDEERALGVSYVPLADLLSQADYVSLNAPATAETYHVIDEAALSMMQPTAFLINTS 240 Query: 240 RGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQE 299 RG+ VD AL AL K +AGA +DVF EP F C+ DNV+LTPH G +T+E Sbjct: 241 RGSQVDEAALLRALKGKRIAGAGLDVFEEEP-----DFNKEFCQLDNVILTPHAGSATRE 295 Query: 300 AQENIGLEVAGKLIKYSDNGSTLSAVN 326 ++ ++ E + ++ + +G ++ VN Sbjct: 296 SRRSVLKEASHNIVSFLVDGVPVNRVN 322 >UniRef50_Q03WU1 Lactate dehydrogenase related dehydrogenase n=3 Tax=Leuconostoc mesenteroides RepID=Q03WU1_LEUMM Length = 312 Score = 347 bits (891), Expect = 5e-94, Method: Composition-based stats. Identities = 87/321 (27%), Positives = 153/321 (47%), Gaps = 11/321 (3%) Query: 8 KDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTE 67 + + +V +H+ A++ +AGY H D+++L DA + + + + Sbjct: 1 MSEKRIHIVGDLHEVAIQKFTSAGYDV--SHSPNYDEKKLLSLASDA-AVIIMTDMAFDK 57 Query: 68 DVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGV 127 + +A L I +G + + +++A K G+ V N P +N +VAEL + +L +LR V Sbjct: 58 NWFDALPNLKLIARRGVGYDNIPVESATKHGVWVTNTPGANAIAVAELAVTLILTVLRKV 117 Query: 128 PEANAKAHRGVW--NKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENK 185 +A +G + GK +G+IGYG I L + G +V Y + Sbjct: 118 NQATNSVQKGEALTYPASLMGHNLSGKIIGLIGYGQIAQNLEKILHGFGAHVLVYSRTKR 177 Query: 186 LPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVD 245 L Q LL SD++SLH+P P T ++ + S MK ++LIN +R +VD Sbjct: 178 ETLYG--QFVSYDTLLAQSDIISLHIPATPETSGILNHEAFSKMKTNAILINTARAALVD 235 Query: 246 IPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIG 305 AL +A+ + +AGA +D E + SPL D +++TPHIG +T E++ Sbjct: 236 EEALVEAINTGKIAGAGLDTTSYE----TIKTASPLLNHDQIVITPHIGANTVESEYLTA 291 Query: 306 LEVAGKLIKYSDNGSTLSAVN 326 +V ++ + +N + +N Sbjct: 292 EKVVASVLDFFNNQKPIYRLN 312 >UniRef50_Q46NL3 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=2 Tax=Burkholderiales RepID=Q46NL3_RALEJ Length = 337 Score = 347 bits (891), Expect = 5e-94, Method: Composition-based stats. Identities = 95/332 (28%), Positives = 150/332 (45%), Gaps = 13/332 (3%) Query: 1 MAKVSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFH--KGALDDEQLKESIRDAHFIG 58 M + S + LL + + +A L A + GA D+ L++ I + Sbjct: 1 MTQASRAGSRALVLLTDPIVPEAHARLAANADVELLPPGLTGAASDQALRDRIAKVDGLI 60 Query: 59 LRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIG 118 +R L D+ +L A+ +G + + +D A GIPV N P +N+ +VAE I Sbjct: 61 VRR--QLPGDLFEREHRLRAVVRHGVGVDFIPVDRATAHGIPVANTPDTNSNAVAEYAIA 118 Query: 119 ELLLLLRGVPEANAKAHRGVWNKLAAGS---FEARGKKLGIIGYGHIGTQLGILA-ESLG 174 +L + R + + G WN+ E RG LGIIG+G IG ++ +A Sbjct: 119 AMLAMTRRLATFDKAVRDGDWNRRMIAGEQSRELRGSTLGIIGFGAIGRRVAEIAGAGFA 178 Query: 175 MYVYFYDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSL 234 M + + + L+DL SD + L P +T+ M+ ++ +P ++ Sbjct: 179 MKLLAHTSTPSKLPPH-VTPAELADLFARSDYIVLACPLTKATRGMVNKALLAHARPTTV 237 Query: 235 LINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIG 294 L+N +RG ++ L DAL+S + GA +DVF P P SPL NVLLTPHI Sbjct: 238 LVNVARGPIIQQADLIDALSSGTIGGAVLDVFEQHPL----PDDSPLRALQNVLLTPHIA 293 Query: 295 GSTQEAQENIGLEVAGKLIKYSDNGSTLSAVN 326 G TQ+A +GL A ++ + VN Sbjct: 294 GLTQDASMAMGLAAADTMLALLQGERPRNIVN 325 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.313 0.186 0.605 Lambda K H 0.267 0.0568 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 3,385,454,081 Number of Sequences: 3077464 Number of extensions: 235522418 Number of successful extensions: 535764 Number of sequences better than 1.0e-01: 250 Number of HSP's better than 0.1 without gapping: 4322 Number of HSP's successfully gapped in prelim test: 658 Number of HSP's that attempted gapping in prelim test: 517117 Number of HSP's gapped (non-prelim): 5686 length of query: 410 length of database: 1,040,396,356 effective HSP length: 131 effective length of query: 279 effective length of database: 637,248,572 effective search space: 177792351588 effective search space used: 177792351588 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.0 bits) S2: 95 (40.7 bits)