Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	K	L	T	V	A	A	L	A	V	T	T	L	L	S	G	S	A	F	A	H	E	A	G	E	F	F	M	R	A	G	S	A	T	V	R	P	T	E	G	A	G	G	T	L	G	S	L	G	G	F	S	V	T	N	N	T	Q	L
Secondary structure
SS confidence
Disorder		?	?														?				?	?																			?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	L	T	F	T	Y	M	A	T	D	N	I	G	V	E	L	L	A	A	T	P	F	R	H	K	I	G	T	R	A	T	G	D	I	A	T	V	H	H	L	P	P	T	L	M	A	Q	W	Y	F	G	D	A	S	S	K	F	R	P	Y
Secondary structure
SS confidence
Disorder																												?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	G	A	G	I	N	Y	T	T	F	F	D	N	G	F	N	D	H	G	K	E	A	G	L	S	D	L	S	L	K	D	S	W	G	A	A	G	Q	V	G	V	D	Y	L	I	N	R	D	W	L	V	N	M	S	V	W	Y	M	D	I
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.
Sequence		D	T	T	A	N	Y	K	L	G	G	A	Q	Q	H	D	S	V	R	L	D	P	W	V	F	M	F	S	A	G	Y	R	F
Secondary structure
SS confidence
Disorder				?						?		?	?	?	?	?																	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2f1t chain B Region: 23 - 212 Aligned: 182 Modelled: 190 Confidence: 100.0% Identity: 97% PDB header:membrane protein Chain: B: PDB Molecule:outer membrane protein w; PDBTitle: outer membrane protein ompw Phyre2 PDB 2x27 chain X Region: 19 - 212 Aligned: 194 Modelled: 194 Confidence: 100.0% Identity: 48% PDB header:membrane protein Chain: X: PDB Molecule:outer membrane protein oprg; PDBTitle: crystal structure of the outer membrane protein oprg from2 pseudomonas aeruginosa Phyre2 PDB 2k0l chain A Region: 8 - 212 Aligned: 190 Modelled: 205 Confidence: 99.9% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein a; PDBTitle: nmr structure of the transmembrane domain of the outer2 membrane protein a from klebsiella pneumoniae in dhpc3 micelles. Phyre2 PDB 1g90 chain A Region: 21 - 212 Aligned: 170 Modelled: 181 Confidence: 99.9% Identity: 13% Fold: Transmembrane beta-barrels Superfamily: OMPA-like Family: Outer membrane protein Phyre2 PDB 1p4t chain A Region: 22 - 212 Aligned: 155 Modelled: 171 Confidence: 99.9% Identity: 17% Fold: Transmembrane beta-barrels Superfamily: OMPA-like Family: Outer membrane protein Phyre2 PDB 1qjp chain A Region: 21 - 212 Aligned: 136 Modelled: 154 Confidence: 99.8% Identity: 16% Fold: Transmembrane beta-barrels Superfamily: OMPA-like Family: Outer membrane protein Phyre2 PDB 3nb3 chain C Region: 21 - 212 Aligned: 136 Modelled: 154 Confidence: 99.8% Identity: 15% PDB header:virus Chain: C: PDB Molecule:outer membrane protein a; PDBTitle: the host outer membrane proteins ompa and ompc are packed at specific2 sites in the shigella phage sf6 virion as structural components Phyre2 PDB 3qra chain A Region: 24 - 212 Aligned: 151 Modelled: 173 Confidence: 99.8% Identity: 21% PDB header:cell invasion Chain: A: PDB Molecule:attachment invasion locus protein; PDBTitle: the crystal structure of ail, the attachment invasion locus protein of2 yersinia pestis Phyre2 PDB 2lhf chain A Region: 26 - 212 Aligned: 171 Modelled: 180 Confidence: 99.8% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein h1; PDBTitle: solution structure of outer membrane protein h (oprh) from p.2 aeruginosa in dhpc micelles Phyre2 PDB 2jmm chain A Region: 20 - 212 Aligned: 150 Modelled: 162 Confidence: 99.8% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein a; PDBTitle: nmr solution structure of a minimal transmembrane beta-2 barrel platform protein Phyre2 PDB 1qj8 chain A Region: 29 - 212 Aligned: 143 Modelled: 154 Confidence: 99.7% Identity: 18% Fold: Transmembrane beta-barrels Superfamily: OMPA-like Family: Outer membrane protein Phyre2 PDB 1t16 chain A Region: 59 - 212 Aligned: 138 Modelled: 154 Confidence: 98.8% Identity: 14% Fold: Transmembrane beta-barrels Superfamily: Porins Family: Outer membrane protein transport protein Phyre2 PDB 3slj chain A Region: 24 - 212 Aligned: 173 Modelled: 174 Confidence: 98.7% Identity: 14% PDB header:protein transport Chain: A: PDB Molecule:serine protease espp; PDBTitle: pre-cleavage structure of the autotransporter espp - n1023a mutant Phyre2 PDB 1uyn chain X Region: 25 - 212 Aligned: 166 Modelled: 172 Confidence: 98.6% Identity: 17% Fold: Transmembrane beta-barrels Superfamily: Autotransporter Family: Autotransporter Phyre2 PDB 3aeh chain B Region: 27 - 212 Aligned: 165 Modelled: 171 Confidence: 98.5% Identity: 11% PDB header:hydrolase Chain: B: PDB Molecule:hemoglobin-binding protease hbp autotransporter; PDBTitle: integral membrane domain of autotransporter hbp Phyre2 PDB 2x4m chain D Region: 55 - 212 Aligned: 157 Modelled: 158 Confidence: 98.5% Identity: 10% PDB header:hydrolase Chain: D: PDB Molecule:coagulase/fibrinolysin; PDBTitle: yersinia pestis plasminogen activator pla Phyre2 PDB 3dwo chain X Region: 41 - 212 Aligned: 163 Modelled: 164 Confidence: 98.4% Identity: 13% PDB header:membrane protein Chain: X: PDB Molecule:probable outer membrane protein; PDBTitle: crystal structure of a pseudomonas aeruginosa fadl homologue Phyre2 PDB 2qom chain B Region: 24 - 212 Aligned: 172 Modelled: 174 Confidence: 98.1% Identity: 10% PDB header:hydrolase Chain: B: PDB Molecule:serine protease espp; PDBTitle: the crystal structure of the e.coli espp autotransporter beta-domain. Phyre2 PDB 1i78 chain A Region: 55 - 212 Aligned: 158 Modelled: 158 Confidence: 98.1% Identity: 11% Fold: Transmembrane beta-barrels Superfamily: OMPT-like Family: Outer membrane protease OMPT Phyre2 PDB 3qq2 chain C Region: 24 - 212 Aligned: 157 Modelled: 157 Confidence: 98.0% Identity: 21% PDB header:membrane protein/protein transport Chain: C: PDB Molecule:brka autotransporter; PDBTitle: crystal structure of the beta domain of the bordetella autotransporter2 brka Phyre2 PDB 2jna chain A domain 1 Region: 1 - 24 Aligned: 24 Modelled: 24 Confidence: 77.1% Identity: 42% Fold: Dodecin subunit-like Superfamily: YdgH-like Family: YdgH-like Phyre2 1 c2f1tB_ 2 c2x27X_ 3 c2k0lA_ 4 d1g90a_ 5 d1p4ta_ 6 d1qjpa_ 7 c3nb3C_ 8 c3qraA_ 9 c2lhfA_ 10 c2jmmA_ 11 d1qj8a_ 12 d1t16a_ 13 c3sljA_ 14 d1uynx_ 15 c3aehB_ 16 c2x4mD_ 17 c3dwoX_ 18 c2qomB_ 19 d1i78a_ 20 c3qq2C_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 d2jnaa1 42 43 44 45 46 47 48 49 50 51 52 53

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2f1tB_ 100.0 97 PDB header:membrane protein Chain: B: PDB Molecule:outer membrane protein w; PDBTitle: outer membrane protein ompw 2 c2x27X_ 100.0 48 PDB header:membrane protein Chain: X: PDB Molecule:outer membrane protein oprg; PDBTitle: crystal structure of the outer membrane protein oprg from2 pseudomonas aeruginosa 3 c2k0lA_ 99.9 13 PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein a; PDBTitle: nmr structure of the transmembrane domain of the outer2 membrane protein a from klebsiella pneumoniae in dhpc3 micelles. 4 d1g90a_ 99.9 13 Fold:Transmembrane beta-barrels Superfamily:OMPA-like Family:Outer membrane protein 5 d1p4ta_ 99.9 17 Fold:Transmembrane beta-barrels Superfamily:OMPA-like Family:Outer membrane protein 6 d1qjpa_ 99.8 16 Fold:Transmembrane beta-barrels Superfamily:OMPA-like Family:Outer membrane protein 7 c3nb3C_ 99.8 15 PDB header:virus Chain: C: PDB Molecule:outer membrane protein a; PDBTitle: the host outer membrane proteins ompa and ompc are packed at specific2 sites in the shigella phage sf6 virion as structural components 8 c3qraA_ 99.8 21 PDB header:cell invasion Chain: A: PDB Molecule:attachment invasion locus protein; PDBTitle: the crystal structure of ail, the attachment invasion locus protein of2 yersinia pestis 9 c2lhfA_ 99.8 11 PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein h1; PDBTitle: solution structure of outer membrane protein h (oprh) from p.2 aeruginosa in dhpc micelles 10 c2jmmA_ 99.8 12 PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein a; PDBTitle: nmr solution structure of a minimal transmembrane beta-2 barrel platform protein 11 d1qj8a_ 99.7 18 Fold:Transmembrane beta-barrels Superfamily:OMPA-like Family:Outer membrane protein 12 d1t16a_ 98.8 14 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Outer membrane protein transport protein 13 c3sljA_ 98.7 14 PDB header:protein transport Chain: A: PDB Molecule:serine protease espp; PDBTitle: pre-cleavage structure of the autotransporter espp - n1023a mutant 14 d1uynx_ 98.6 17 Fold:Transmembrane beta-barrels Superfamily:Autotransporter Family:Autotransporter 15 c3aehB_ 98.5 11 PDB header:hydrolase Chain: B: PDB Molecule:hemoglobin-binding protease hbp autotransporter; PDBTitle: integral membrane domain of autotransporter hbp 16 c2x4mD_ 98.5 10 PDB header:hydrolase Chain: D: PDB Molecule:coagulase/fibrinolysin; PDBTitle: yersinia pestis plasminogen activator pla 17 c3dwoX_ 98.4 13 PDB header:membrane protein Chain: X: PDB Molecule:probable outer membrane protein; PDBTitle: crystal structure of a pseudomonas aeruginosa fadl homologue 18 c2qomB_ 98.1 10 PDB header:hydrolase Chain: B: PDB Molecule:serine protease espp; PDBTitle: the crystal structure of the e.coli espp autotransporter beta-domain. 19 d1i78a_ 98.1 11 Fold:Transmembrane beta-barrels Superfamily:OMPT-like Family:Outer membrane protease OMPT 20 c3qq2C_ 98.0 21 PDB header:membrane protein/protein transport Chain: C: PDB Molecule:brka autotransporter; PDBTitle: crystal structure of the beta domain of the bordetella autotransporter2 brka 21 c2iwvD_ not modelled 97.9 8 PDB header:ion channel Chain: D: PDB Molecule:outer membrane protein g; PDBTitle: structure of the monomeric outer membrane porin ompg in the2 open and closed conformation 22 c3kvnA_ not modelled 97.8 8 PDB header:hydrolase Chain: A: PDB Molecule:esterase esta; PDBTitle: crystal structure of the full-length autotransporter esta from2 pseudomonas aeruginosa 23 c3brzA_ not modelled 97.6 14 PDB header:transport protein Chain: A: PDB Molecule:todx; PDBTitle: crystal structure of the pseudomonas putida toluene2 transporter todx 24 c3bryB_ not modelled 97.3 14 PDB header:transport protein Chain: B: PDB Molecule:tbux; PDBTitle: crystal structure of the ralstonia pickettii toluene2 transporter tbux 25 c2iahA_ not modelled 96.1 14 PDB header:membrane protein Chain: A: PDB Molecule:ferripyoverdine receptor; PDBTitle: crystal structure of the ferripyoverdine receptor of the outer2 membrane of pseudomonas aeruginosa bound to ferripyoverdine. 26 d2fgqx1 not modelled 95.8 11 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Porin 27 c2hdiA_ not modelled 95.6 11 PDB header:protein transport,antimicrobial protein Chain: A: PDB Molecule:colicin i receptor; PDBTitle: crystal structure of the colicin i receptor cir from e.coli in complex2 with receptor binding domain of colicin ia. 28 c3dzmB_ not modelled 95.6 16 PDB header:unknown function Chain: B: PDB Molecule:hypothetical conserved protein; PDBTitle: crystal structure of a major outer membrane protein from thermus2 thermophilus hb27 29 d1phoa_ not modelled 95.4 14 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Porin 30 c1xkhC_ not modelled 95.4 13 PDB header:membrane protein Chain: C: PDB Molecule:ferripyoverdine receptor; PDBTitle: pyoverdine outer membrane receptor fpva from pseudomonas aeruginosa2 pao1 bound to pyoverdine 31 d2zfga1 not modelled 95.2 15 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Porin 32 d1osma_ not modelled 94.6 16 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Porin 33 c2ervA_ not modelled 94.5 15 PDB header:membrane protein Chain: A: PDB Molecule:hypothetical protein paer03002360; PDBTitle: crystal structure of the outer membrane enzyme pagl 34 c1xkwA_ not modelled 94.0 13 PDB header:membrane protein Chain: A: PDB Molecule:fe(iii)-pyochelin receptor; PDBTitle: pyochelin outer membrane receptor fpta from pseudomonas2 aeruginosa 35 d2vdfa1 not modelled 93.3 12 Fold:Transmembrane beta-barrels Superfamily:OMPT-like Family:Outer membrane adhesin/invasin OpcA 36 c2wjqA_ not modelled 92.7 12 PDB header:transport protein Chain: A: PDB Molecule:probable n-acetylneuraminic acid outer membrane channel PDBTitle: nanc porin structure in hexagonal crystal form. 37 c3a2rX_ not modelled 91.5 12 PDB header:membrane protein Chain: X: PDB Molecule:outer membrane protein ii; PDBTitle: crystal structure of outer membrane protein porb from neisseria2 meningitidis 38 c3nsgA_ not modelled 89.4 15 PDB header:membrane protein Chain: A: PDB Molecule:outer membrane protein f; PDBTitle: crystal structure of ompf, an outer membrane protein from salmonella2 typhi 39 d2pora_ not modelled 86.0 15 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Porin 40 d1fepa_ not modelled 77.9 7 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Ligand-gated protein channel 41 d2jnaa1 77.1 42 Fold:Dodecin subunit-like Superfamily:YdgH-like Family:YdgH-like 42 c2grxB_ not modelled 75.7 9 PDB header:metal transport Chain: B: PDB Molecule:ferrichrome-iron receptor; PDBTitle: crystal structure of tonb in complex with fhua, e. coli2 outer membrane receptor for ferrichrome 43 d1by5a_ not modelled 70.3 9 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Ligand-gated protein channel 44 c3cslB_ not modelled 70.3 15 PDB header:membrane protein/heme binding protein Chain: B: PDB Molecule:hasr protein; PDBTitle: structure of the serratia marcescens hemophore receptor hasr in2 complex with its hemophore hasa and heme 45 d3prna_ not modelled 68.4 15 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Porin 46 c3qlbA_ not modelled 59.3 7 PDB header:metal transport Chain: A: PDB Molecule:enantio-pyochelin receptor; PDBTitle: enantiopyochelin outer membrane tonb-dependent transporter from2 pseudomonas fluorescens bound to the ferri-enantiopyochelin 47 c2qdzA_ not modelled 24.1 18 PDB header:protein transport Chain: A: PDB Molecule:tpsb transporter fhac; PDBTitle: structure of the membrane protein fhac: a member of the2 omp85/tpsb transporter family 48 d2gufa1 not modelled 20.5 11 Fold:Transmembrane beta-barrels Superfamily:Porins Family:Ligand-gated protein channel 49 d1tlya_ not modelled 17.8 10 Fold:Transmembrane beta-barrels Superfamily:Tsx-like channel Family:Tsx-like channel 50 c2o4vA_ not modelled 16.7 12 PDB header:membrane protein Chain: A: PDB Molecule:porin p; PDBTitle: an arginine ladder in oprp mediates phosphate specific transfer across2 the outer membrane 51 d2noca1 not modelled 16.3 21 Fold:Dodecin subunit-like Superfamily:YdgH-like Family:YdgH-like 52 c2vdaB_ not modelled 9.1 30 PDB header:protein transport Chain: B: PDB Molecule:maltoporin; PDBTitle: solution structure of the seca-signal peptide complex 53 c3efmA_ not modelled 6.3 11 PDB header:membrane protein Chain: A: PDB Molecule:ferric alcaligin siderophore receptor; PDBTitle: structure of the alcaligin outer membrane recepteur faua from2 bordetella pertussis

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0