Phyre 2 Results for P26616

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Email | l.a.kelley@imperial.ac.uk
Description | P26616
Date | Thu Jan 5 11:43:01 GMT 2012
Unique Job ID | efb528c863f98b07

Summary |

Top model
Image coloured by rainbow N → C terminus
| Close Jmol

Model (left) based on template c1o0sB_
Top template information
PDB header:oxidoreductase Chain: B: PDB Molecule:nad-dependent malic enzyme; PDBTitle: crystal structure of ascaris suum malic enzyme complexed with nadh
Confidence and coverage
Confidence: | 100.0% | Coverage: | 97%
550 residues ( 97% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis |

Secondary structure and disorder prediction |

|  | 1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60
Sequence |  | M | E | P | K | T | K | K | Q | R | S | L | Y | I | P | Y | A | G | P | V | L | L | E | F | P | L | L | N | K | G | S | A | F | S | M | E | E | R | R | N | F | N | L | L | G | L | L | P | E | V | V | E | T | I | E | E | Q | A | E | R | A
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120
Sequence |  | W | I | Q | Y | Q | G | F | K | T | E | I | D | K | H | I | Y | L | R | N | I | Q | D | T | N | E | T | L | F | Y | R | L | V | N | N | H | L | D | E | M | M | P | V | I | Y | T | P | T | V | G | A | A | C | E | R | F | S | E | I | Y | R
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180
Sequence |  | R | S | R | G | V | F | I | S | Y | Q | N | R | H | N | M | D | D | I | L | Q | N | V | P | N | H | N | I | K | V | I | V | V | T | D | G | E | R | I | L | G | L | G | D | Q | G | I | G | G | M | G | I | P | I | G | K | L | S | L | Y | T
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240
Sequence |  | A | C | G | G | I | S | P | A | Y | T | L | P | V | V | L | D | V | G | T | N | N | Q | Q | L | L | N | D | P | L | Y | M | G | W | R | N | P | R | I | T | D | D | E | Y | Y | E | F | V | D | E | F | I | Q | A | V | K | Q | R | W | P | D
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300
Sequence |  | V | L | L | Q | F | E | D | F | A | Q | K | N | A | M | P | L | L | N | R | Y | R | N | E | I | C | S | F | N | D | D | I | Q | G | T | A | A | V | T | V | G | T | L | I | A | A | S | R | A | A | G | G | Q | L | S | E | K | K | I | V | F
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | 360
Sequence |  | L | G | A | G | S | A | G | C | G | I | A | E | M | I | I | S | Q | T | Q | R | E | G | L | S | E | E | A | A | R | Q | K | V | F | M | V | D | R | F | G | L | L | T | D | K | M | P | N | L | L | P | F | Q | T | K | L | V | Q | K | R | E
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  |  |  | ? |  |  |  |  |  |  |  |  |  |  | ? |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | . | . | . | . | . | . | . | . | 400 | . | . | . | . | . | . | . | . | . | 410 | . | . | . | . | . | . | . | . | . | 420
Sequence |  | N | L | S | D | W | D | T | D | S | D | V | L | S | L | L | D | V | V | R | N | V | K | P | D | I | L | I | G | V | S | G | Q | T | G | L | F | T | E | E | I | I | R | E | M | H | K | H | C | P | R | P | I | V | M | P | L | S | N | P | T
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . | . | . | . | . | 460 | . | . | . | . | . | . | . | . | . | 470 | . | . | . | . | . | . | . | . | . | 480
Sequence |  | S | R | V | E | A | T | P | Q | D | I | I | A | W | T | E | G | N | A | L | V | A | T | G | S | P | F | N | P | V | V | W | K | D | K | I | Y | P | I | A | Q | C | N | N | A | F | I | F | P | G | I | G | L | G | V | I | A | S | G | A | S
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 490 | . | . | . | . | . | . | . | . | . | 500 | . | . | . | . | . | . | . | . | . | 510 | . | . | . | . | . | . | . | . | . | 520 | . | . | . | . | . | . | . | . | . | 530 | . | . | . | . | . | . | . | . | . | 540
Sequence |  | R | I | T | D | E | M | L | M | S | A | S | E | T | L | A | Q | Y | S | P | L | V | L | N | G | E | G | M | V | L | P | E | L | K | D | I | Q | K | V | S | R | A | I | A | F | A | V | G | K | M | A | Q | Q | Q | G | V | A | V | K | T | S
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? |  | ? |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 550 | . | . | . | . | . | . | . | . | . | 560 | . | . | . | . | .
Sequence |  | A | E | A | L | Q | Q | A | I | D | D | N | F | W | Q | A | E | Y | R | D | Y | R | R | T | S | I
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

Confidence Key
High(9) |  |  |  |  |  |  |  |  |  |  | Low (0)

? | Disordered
| Alpha helix
| Beta strand

Domain analysis |

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank | Aligned region
--- | ---
1 |
| c1o0sB_ |

### PDB 1o0s chain B

Region: 6 - 564
Aligned: 550
Modelled: 559
Confidence: 100.0%
Identity: 40%
PDB header:oxidoreductase
Chain: B: PDB Molecule:nad-dependent malic enzyme;
PDBTitle: crystal structure of ascaris suum malic enzyme complexed with nadh

Phyre2
2 |
| c1gz3B_ |

### PDB 1gz3 chain B

Region: 12 - 564
Aligned: 546
Modelled: 553
Confidence: 100.0%
Identity: 41%
PDB header:oxidoreductase
Chain: B: PDB Molecule:nad-dependent malic enzyme;
PDBTitle: molecular mechanism for the regulation of human mitochondrial2 nad(p)+-dependent malic enzyme by atp and fumarate

Phyre2
3 |
| c1qr6A_ |

### PDB 1qr6 chain A

Region: 15 - 564
Aligned: 543
Modelled: 550
Confidence: 100.0%
Identity: 40%
PDB header:oxidoreductase
Chain: A: PDB Molecule:malic enzyme 2;
PDBTitle: human mitochondrial nad(p)-dependent malic enzyme

Phyre2
4 |
| c2aw5A_ |

### PDB 2aw5 chain A

Region: 17 - 558
Aligned: 527
Modelled: 542
Confidence: 100.0%
Identity: 43%
PDB header:oxidoreductase
Chain: A: PDB Molecule:nadp-dependent malic enzyme;
PDBTitle: crystal structure of a human malic enzyme

Phyre2
5 |
| c3nv9A_ |

### PDB 3nv9 chain A

Region: 45 - 554
Aligned: 442
Modelled: 499
Confidence: 100.0%
Identity: 27%
PDB header:oxidoreductase
Chain: A: PDB Molecule:malic enzyme;
PDBTitle: crystal structure of entamoeba histolytica malic enzyme

Phyre2
6 |
| c1ww8A_ |

### PDB 1ww8 chain A

Region: 98 - 562
Aligned: 386
Modelled: 419
Confidence: 100.0%
Identity: 30%
PDB header:oxidoreductase
Chain: A: PDB Molecule:malate oxidoreductase;
PDBTitle: crystal structure of malic enzyme from pyrococcus2 horikoshii ot3

Phyre2
7 |
| c1vl6C_ |

### PDB 1vl6 chain C

Region: 88 - 530
Aligned: 356
Modelled: 403
Confidence: 100.0%
Identity: 29%
PDB header:oxidoreductase
Chain: C: PDB Molecule:malate oxidoreductase;
PDBTitle: crystal structure of nad-dependent malic enzyme (tm0542) from2 thermotoga maritima at 2.61 a resolution

Phyre2
8 |
| c2a9fB_ |

### PDB 2a9f chain B

Region: 97 - 526
Aligned: 344
Modelled: 385
Confidence: 100.0%
Identity: 30%
PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:putative malic enzyme ((s)-malate:nad+
PDBTitle: crystal structure of a putative malic enzyme ((s)-2 malate:nad+ oxidoreductase (decarboxylating))

Phyre2
9 |
| d1o0sa2 |

### PDB 1o0s chain A domain 2

Region: 7 - 270
Aligned: 264
Modelled: 264
Confidence: 100.0%
Identity: 45%
Fold: Aminoacid dehydrogenase-like, N-terminal domain
Superfamily: Aminoacid dehydrogenase-like, N-terminal domain
Family: Malic enzyme N-domain

Phyre2
10 |
| d1pj3a2 |

### PDB 1pj3 chain A domain 2

Region: 13 - 270
Aligned: 258
Modelled: 258
Confidence: 100.0%
Identity: 46%
Fold: Aminoacid dehydrogenase-like, N-terminal domain
Superfamily: Aminoacid dehydrogenase-like, N-terminal domain
Family: Malic enzyme N-domain

Phyre2
11 |
| d1gq2a2 |

### PDB 1gq2 chain A domain 2

Region: 15 - 270
Aligned: 256
Modelled: 256
Confidence: 100.0%
Identity: 48%
Fold: Aminoacid dehydrogenase-like, N-terminal domain
Superfamily: Aminoacid dehydrogenase-like, N-terminal domain
Family: Malic enzyme N-domain

Phyre2
12 |
| d1o0sa1 |

### PDB 1o0s chain A domain 1

Region: 271 - 564
Aligned: 285
Modelled: 294
Confidence: 100.0%
Identity: 35%
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Family: Aminoacid dehydrogenase-like, C-terminal domain

Phyre2
13 |
| d1pj3a1 |

### PDB 1pj3 chain A domain 1

Region: 271 - 564
Aligned: 287
Modelled: 294
Confidence: 100.0%
Identity: 34%
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Family: Aminoacid dehydrogenase-like, C-terminal domain

Phyre2
14 |
| d1gq2a1 |

### PDB 1gq2 chain A domain 1

Region: 271 - 564
Aligned: 285
Modelled: 294
Confidence: 100.0%
Identity: 36%
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Family: Aminoacid dehydrogenase-like, C-terminal domain

Phyre2
15 |
| d1vl6a1 |

### PDB 1vl6 chain A domain 1

Region: 270 - 530
Aligned: 220
Modelled: 251
Confidence: 100.0%
Identity: 31%
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Family: Aminoacid dehydrogenase-like, C-terminal domain

Phyre2
16 |
| d1vl6a2 |

### PDB 1vl6 chain A domain 2

Region: 86 - 269
Aligned: 137
Modelled: 146
Confidence: 100.0%
Identity: 24%
Fold: Aminoacid dehydrogenase-like, N-terminal domain
Superfamily: Aminoacid dehydrogenase-like, N-terminal domain
Family: Malic enzyme N-domain

Phyre2
17 |
| d1euza1 |

### PDB 1euz chain A domain 1

Region: 272 - 421
Aligned: 135
Modelled: 150
Confidence: 98.3%
Identity: 20%
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Family: Aminoacid dehydrogenase-like, C-terminal domain

Phyre2
18 |
| d1li4a1 |

### PDB 1li4 chain A domain 1

Region: 269 - 432
Aligned: 124
Modelled: 145
Confidence: 98.0%
Identity: 20%
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Family: Formate/glycerate dehydrogenases, NAD-domain

Phyre2
19 |
| c3n58D_ |

### PDB 3n58 chain D

Region: 215 - 525
Aligned: 260
Modelled: 292
Confidence: 97.7%
Identity: 19%
PDB header:hydrolase
Chain: D: PDB Molecule:adenosylhomocysteinase;
PDBTitle: crystal structure of s-adenosyl-l-homocysteine hydrolase from brucella2 melitensis in ternary complex with nad and adenosine, orthorhombic3 form

Phyre2
20 |
| d1v9la1 |

### PDB 1v9l chain A domain 1

Region: 272 - 421
Aligned: 136
Modelled: 140
Confidence: 97.6%
Identity: 14%
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Family: Aminoacid dehydrogenase-like, C-terminal domain

Phyre2
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Detailed template information |

# | Template | Alignment Coverage | 3D Model | Confidence | % i.d. | Template Information
--- | --- | --- | --- | --- | --- | ---
1 | c1o0sB_ |
|  | 100.0 | 40 | PDB header:oxidoreductase Chain: B: PDB Molecule:nad-dependent malic enzyme; PDBTitle: crystal structure of ascaris suum malic enzyme complexed with nadh
2 | c1gz3B_ |
|  | 100.0 | 41 | PDB header:oxidoreductase Chain: B: PDB Molecule:nad-dependent malic enzyme; PDBTitle: molecular mechanism for the regulation of human mitochondrial2 nad(p)+-dependent malic enzyme by atp and fumarate
3 | c1qr6A_ |
|  | 100.0 | 40 | PDB header:oxidoreductase Chain: A: PDB Molecule:malic enzyme 2; PDBTitle: human mitochondrial nad(p)-dependent malic enzyme
4 | c2aw5A_ |
|  | 100.0 | 43 | PDB header:oxidoreductase Chain: A: PDB Molecule:nadp-dependent malic enzyme; PDBTitle: crystal structure of a human malic enzyme
5 | c3nv9A_ |
|  | 100.0 | 27 | PDB header:oxidoreductase Chain: A: PDB Molecule:malic enzyme; PDBTitle: crystal structure of entamoeba histolytica malic enzyme
6 | c1ww8A_ |
|  | 100.0 | 30 | PDB header:oxidoreductase Chain: A: PDB Molecule:malate oxidoreductase; PDBTitle: crystal structure of malic enzyme from pyrococcus2 horikoshii ot3
7 | c1vl6C_ |
|  | 100.0 | 29 | PDB header:oxidoreductase Chain: C: PDB Molecule:malate oxidoreductase; PDBTitle: crystal structure of nad-dependent malic enzyme (tm0542) from2 thermotoga maritima at 2.61 a resolution
8 | c2a9fB_ |
|  | 100.0 | 30 | PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative malic enzyme ((s)-malate:nad+ PDBTitle: crystal structure of a putative malic enzyme ((s)-2 malate:nad+ oxidoreductase (decarboxylating))
9 | d1o0sa2 |
|  | 100.0 | 45 | Fold:Aminoacid dehydrogenase-like, N-terminal domain Superfamily:Aminoacid dehydrogenase-like, N-terminal domain Family:Malic enzyme N-domain
10 | d1pj3a2 |
|  | 100.0 | 46 | Fold:Aminoacid dehydrogenase-like, N-terminal domain Superfamily:Aminoacid dehydrogenase-like, N-terminal domain Family:Malic enzyme N-domain
11 | d1gq2a2 |
|  | 100.0 | 48 | Fold:Aminoacid dehydrogenase-like, N-terminal domain Superfamily:Aminoacid dehydrogenase-like, N-terminal domain Family:Malic enzyme N-domain
12 | d1o0sa1 |
|  | 100.0 | 35 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain
13 | d1pj3a1 |
|  | 100.0 | 34 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain
14 | d1gq2a1 |
|  | 100.0 | 36 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain
15 | d1vl6a1 |
|  | 100.0 | 31 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain
16 | d1vl6a2 |
|  | 100.0 | 24 | Fold:Aminoacid dehydrogenase-like, N-terminal domain Superfamily:Aminoacid dehydrogenase-like, N-terminal domain Family:Malic enzyme N-domain
17 | d1euza1 |
|  | 98.3 | 20 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain
18 | d1li4a1 |
|  | 98.0 | 20 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain
19 | c3n58D_ |
|  | 97.7 | 19 | PDB header:hydrolase Chain: D: PDB Molecule:adenosylhomocysteinase; PDBTitle: crystal structure of s-adenosyl-l-homocysteine hydrolase from brucella2 melitensis in ternary complex with nad and adenosine, orthorhombic3 form
20 | d1v9la1 |
|  | 97.6 | 14 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain
21 | d1v8ba1 |
| not modelled | 97.4 | 22 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain
22 | c3aogA_ |
| not modelled | 97.3 | 16 | PDB header:oxidoreductase Chain: A: PDB Molecule:glutamate dehydrogenase; PDBTitle: crystal structure of glutamate dehydrogenase (gdhb) from thermus2 thermophilus (glu bound form)
23 | c3dhyC_ |
| not modelled | 97.3 | 21 | PDB header:hydrolase Chain: C: PDB Molecule:adenosylhomocysteinase; PDBTitle: crystal structures of mycobacterium tuberculosis s-adenosyl-l-2 homocysteine hydrolase in ternary complex with substrate and3 inhibitors
24 | d1uxja1 |
| not modelled | 97.2 | 19 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
25 | c3gvpB_ |
| not modelled | 97.2 | 16 | PDB header:hydrolase Chain: B: PDB Molecule:adenosylhomocysteinase 3; PDBTitle: human sahh-like domain of human adenosylhomocysteinase 3
26 | c2rirA_ |
| not modelled | 97.1 | 22 | PDB header:oxidoreductase Chain: A: PDB Molecule:dipicolinate synthase, a chain; PDBTitle: crystal structure of dipicolinate synthase, a chain, from bacillus2 subtilis
27 | c2bmaA_ |
| not modelled | 97.1 | 14 | PDB header:oxidoreductase Chain: A: PDB Molecule:glutamate dehydrogenase (nadp+); PDBTitle: the crystal structure of plasmodium falciparum glutamate2 dehydrogenase, a putative target for novel antimalarial3 drugs
28 | c3d4oA_ |
| not modelled | 97.1 | 21 | PDB header:oxidoreductase Chain: A: PDB Molecule:dipicolinate synthase subunit a; PDBTitle: crystal structure of dipicolinate synthase subunit a (np_243269.1)2 from bacillus halodurans at 2.10 a resolution
29 | c1d4fD_ |
| not modelled | 97.0 | 15 | PDB header:hydrolase Chain: D: PDB Molecule:s-adenosylhomocysteine hydrolase; PDBTitle: crystal structure of recombinant rat-liver d244e mutant s-2 adenosylhomocysteine hydrolase
30 | d1t2da1 |
| not modelled | 97.0 | 20 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
31 | c3aoeC_ |
| not modelled | 96.9 | 15 | PDB header:oxidoreductase Chain: C: PDB Molecule:glutamate dehydrogenase; PDBTitle: crystal structure of hetero-hexameric glutamate dehydrogenase from2 thermus thermophilus (leu bound form)
32 | d1pzga1 |
| not modelled | 96.8 | 20 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
33 | d1gpja2 |
| not modelled | 96.7 | 21 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain
34 | d1l7da1 |
| not modelled | 96.7 | 19 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain
35 | c1v9lA_ |
| not modelled | 96.6 | 15 | PDB header:oxidoreductase Chain: A: PDB Molecule:glutamate dehydrogenase; PDBTitle: l-glutamate dehydrogenase from pyrobaculum islandicum2 complexed with nad
36 | d1u8xx1 |
| not modelled | 96.6 | 20 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
37 | c1pzfD_ |
| not modelled | 96.6 | 19 | PDB header:oxidoreductase Chain: D: PDB Molecule:lactate dehydrogenase; PDBTitle: t.gondii ldh1 ternary complex with apad+ and oxalate
38 | c3d64A_ |
| not modelled | 96.6 | 17 | PDB header:hydrolase Chain: A: PDB Molecule:adenosylhomocysteinase; PDBTitle: crystal structure of s-adenosyl-l-homocysteine hydrolase from2 burkholderia pseudomallei
39 | d1bvua1 |
| not modelled | 96.5 | 21 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain
40 | c1gpjA_ |
| not modelled | 96.5 | 21 | PDB header:reductase Chain: A: PDB Molecule:glutamyl-trna reductase; PDBTitle: glutamyl-trna reductase from methanopyrus kandleri
41 | d1vi2a1 |
| not modelled | 96.5 | 18 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain
42 | c1bvuF_ |
| not modelled | 96.4 | 19 | PDB header:oxidoreductase Chain: F: PDB Molecule:protein (glutamate dehydrogenase); PDBTitle: glutamate dehydrogenase from thermococcus litoralis
43 | c1obbB_ |
| not modelled | 96.4 | 24 | PDB header:hydrolase Chain: B: PDB Molecule:alpha-glucosidase; PDBTitle: alpha-glucosidase a, agla, from thermotoga maritima in2 complex with maltose and nad+
44 | c1nr1A_ |
| not modelled | 96.3 | 16 | PDB header:oxidoreductase Chain: A: PDB Molecule:glutamate dehydrogenase 1; PDBTitle: crystal structure of the r463a mutant of human glutamate2 dehydrogenase
45 | c1pjcA_ |
| not modelled | 96.2 | 24 | PDB header:oxidoreductase Chain: A: PDB Molecule:protein (l-alanine dehydrogenase); PDBTitle: l-alanine dehydrogenase complexed with nad
46 | d1s6ya1 |
| not modelled | 96.2 | 21 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
47 | c3tozA_ |
| not modelled | 96.1 | 18 | PDB header:oxidoreductase Chain: A: PDB Molecule:shikimate dehydrogenase; PDBTitle: 2.2 angstrom crystal structure of shikimate 5-dehydrogenase from2 listeria monocytogenes in complex with nad.
48 | d1llda1 |
| not modelled | 96.0 | 21 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
49 | c1hrdA_ |
| not modelled | 96.0 | 16 | PDB header:oxidoreductase Chain: A: PDB Molecule:glutamate dehydrogenase; PDBTitle: glutamate dehydrogenase
50 | c2fnzA_ |
| not modelled | 96.0 | 18 | PDB header:oxidoreductase Chain: A: PDB Molecule:lactate dehydrogenase; PDBTitle: crystal structure of the lactate dehydrogenase from cryptosporidium2 parvum complexed with cofactor (b-nicotinamide adenine dinucleotide)3 and inhibitor (oxamic acid)
51 | c3fefB_ |
| not modelled | 96.0 | 28 | PDB header:hydrolase Chain: B: PDB Molecule:putative glucosidase lpld; PDBTitle: crystal structure of putative glucosidase lpld from2 bacillus subtilis
52 | c2eezG_ |
| not modelled | 96.0 | 17 | PDB header:oxidoreductase Chain: G: PDB Molecule:alanine dehydrogenase; PDBTitle: crystal structure of alanine dehydrogenase from themus thermophilus
53 | d1a4ia1 |
| not modelled | 95.8 | 22 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain
54 | d1i10a1 |
| not modelled | 95.8 | 23 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
55 | c3p2yA_ |
| not modelled | 95.7 | 18 | PDB header:oxidoreductase Chain: A: PDB Molecule:alanine dehydrogenase/pyridine nucleotide transhydrogenase; PDBTitle: crystal structure of alanine dehydrogenase/pyridine nucleotide2 transhydrogenase from mycobacterium smegmatis
56 | c1u8xX_ |
| not modelled | 95.7 | 17 | PDB header:hydrolase Chain: X: PDB Molecule:maltose-6'-phosphate glucosidase; PDBTitle: crystal structure of glva from bacillus subtilis, a metal-requiring,2 nad-dependent 6-phospho-alpha-glucosidase
57 | d9ldta1 |
| not modelled | 95.6 | 22 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
58 | d1obba1 |
| not modelled | 95.6 | 25 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
59 | d1vjta1 |
| not modelled | 95.6 | 25 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
60 | c2ep9A_ |
| not modelled | 95.6 | 17 | PDB header:oxidoreductase Chain: A: PDB Molecule:l-gulonate 3-dehydrogenase; PDBTitle: crystal structure of the rabbit l-gulonate 3-dehydrogenase2 (nadh form)
61 | d1b0aa1 |
| not modelled | 95.6 | 21 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain
62 | d1ldna1 |
| not modelled | 95.5 | 15 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
63 | c1v8bA_ |
| not modelled | 95.5 | 17 | PDB header:hydrolase Chain: A: PDB Molecule:adenosylhomocysteinase; PDBTitle: crystal structure of a hydrolase
64 | c3l07B_ |
| not modelled | 95.4 | 22 | PDB header:oxidoreductase,hydrolase Chain: B: PDB Molecule:bifunctional protein fold; PDBTitle: methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate2 cyclohydrolase, putative bifunctional protein fold from francisella3 tularensis.
65 | d1gtma1 |
| not modelled | 95.4 | 21 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain
66 | d1ojua1 |
| not modelled | 95.4 | 17 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
67 | c1a4iB_ |
| not modelled | 95.4 | 22 | PDB header:oxidoreductase Chain: B: PDB Molecule:methylenetetrahydrofolate dehydrogenase / PDBTitle: human tetrahydrofolate dehydrogenase / cyclohydrolase
68 | d1guza1 |
| not modelled | 95.3 | 25 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
69 | c1ur5C_ |
| not modelled | 95.3 | 19 | PDB header:oxidoreductase Chain: C: PDB Molecule:malate dehydrogenase; PDBTitle: stabilization of a tetrameric malate dehydrogenase by2 introduction of a disulfide bridge at the dimer/dimer3 interface
70 | c2hjrK_ |
| not modelled | 95.3 | 21 | PDB header:oxidoreductase Chain: K: PDB Molecule:malate dehydrogenase; PDBTitle: crystal structure of cryptosporidium parvum malate2 dehydrogenase
71 | d1pjca1 |
| not modelled | 95.3 | 20 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain
72 | d1ez4a1 |
| not modelled | 95.3 | 15 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
73 | c3oneA_ |
| not modelled | 95.2 | 20 | PDB header:hydrolase/hydrolase substrate Chain: A: PDB Molecule:adenosylhomocysteinase; PDBTitle: crystal structure of lupinus luteus s-adenosyl-l-homocysteine2 hydrolase in complex with adenine
74 | d1b26a1 |
| not modelled | 95.2 | 13 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain
75 | c1u4sA_ |
| not modelled | 95.2 | 25 | PDB header:oxidoreductase Chain: A: PDB Molecule:l-lactate dehydrogenase; PDBTitle: plasmodium falciparum lactate dehydrogenase complexed with 2,6-2 naphthalenedisulphonic acid
76 | c1wwkA_ |
| not modelled | 95.1 | 26 | PDB header:oxidoreductase Chain: A: PDB Molecule:phosphoglycerate dehydrogenase; PDBTitle: crystal structure of phosphoglycerate dehydrogenase from pyrococcus2 horikoshii ot3
77 | d1a5za1 |
| not modelled | 95.1 | 20 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
78 | c2tmgD_ |
| not modelled | 95.1 | 13 | PDB header:oxidoreductase Chain: D: PDB Molecule:protein (glutamate dehydrogenase); PDBTitle: thermotoga maritima glutamate dehydrogenase mutant s128r,2 t158e, n117r, s160e
79 | c2v6bB_ |
| not modelled | 95.1 | 16 | PDB header:oxidoreductase Chain: B: PDB Molecule:l-lactate dehydrogenase; PDBTitle: crystal structure of lactate dehydrogenase from deinococcus2 radiodurans (apo form)
80 | d1gv0a1 |
| not modelled | 95.0 | 23 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
81 | d1y6ja1 |
| not modelled | 95.0 | 21 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
82 | c2j6iC_ |
| not modelled | 95.0 | 18 | PDB header:oxidoreductase Chain: C: PDB Molecule:formate dehydrogenase; PDBTitle: candida boidinii formate dehydrogenase (fdh) c-terminal2 mutant
83 | c3evtA_ |
| not modelled | 95.0 | 16 | PDB header:oxidoreductase Chain: A: PDB Molecule:phosphoglycerate dehydrogenase; PDBTitle: crystal structure of phosphoglycerate dehydrogenase from2 lactobacillus plantarum
84 | c4a5oB_ |
| not modelled | 95.0 | 26 | PDB header:oxidoreductase Chain: B: PDB Molecule:bifunctional protein fold; PDBTitle: crystal structure of pseudomonas aeruginosa n5, n10-2 methylenetetrahydrofolate dehydrogenase-cyclohydrolase (fold)
85 | c1s6yA_ |
| not modelled | 94.9 | 17 | PDB header:hydrolase Chain: A: PDB Molecule:6-phospho-beta-glucosidase; PDBTitle: 2.3a crystal structure of phospho-beta-glucosidase
86 | c3d0oA_ |
| not modelled | 94.7 | 19 | PDB header:oxidoreductase Chain: A: PDB Molecule:l-lactate dehydrogenase 1; PDBTitle: crystal structure of lactate dehydrogenase from2 staphylococcus aureus
87 | c3p2oA_ |
| not modelled | 94.7 | 24 | PDB header:oxidoreductase, hydrolase Chain: A: PDB Molecule:bifunctional protein fold; PDBTitle: crystal structure of fold bifunctional protein from campylobacter2 jejuni
88 | c3p2oB_ |
| not modelled | 94.5 | 23 | PDB header:oxidoreductase, hydrolase Chain: B: PDB Molecule:bifunctional protein fold; PDBTitle: crystal structure of fold bifunctional protein from campylobacter2 jejuni
89 | c4a26B_ |
| not modelled | 94.5 | 27 | PDB header:oxidoreductase Chain: B: PDB Molecule:putative c-1-tetrahydrofolate synthase, cytoplasmic; PDBTitle: the crystal structure of leishmania major n5,n10-2 methylenetetrahydrofolate dehydrogenase/cyclohydrolase
90 | c2cukC_ |
| not modelled | 94.5 | 27 | PDB header:oxidoreductase Chain: C: PDB Molecule:glycerate dehydrogenase/glyoxylate reductase; PDBTitle: crystal structure of tt0316 protein from thermus thermophilus hb8
91 | c1ez4B_ |
| not modelled | 94.5 | 18 | PDB header:oxidoreductase Chain: B: PDB Molecule:lactate dehydrogenase; PDBTitle: crystal structure of non-allosteric l-lactate dehydrogenase2 from lactobacillus pentosus at 2.3 angstrom resolution
92 | c3gviB_ |
| not modelled | 94.5 | 20 | PDB header:oxidoreductase Chain: B: PDB Molecule:malate dehydrogenase; PDBTitle: crystal structure of lactate/malate dehydrogenase from2 brucella melitensis in complex with adp
93 | c3nepX_ |
| not modelled | 94.4 | 24 | PDB header:oxidoreductase Chain: X: PDB Molecule:malate dehydrogenase; PDBTitle: 1.55a resolution structure of malate dehydrogenase from salinibacter2 ruber
94 | c3k8zD_ |
| not modelled | 94.4 | 20 | PDB header:oxidoreductase Chain: D: PDB Molecule:nad-specific glutamate dehydrogenase; PDBTitle: crystal structure of gudb1 a decryptified secondary glutamate2 dehydrogenase from b. subtilis
95 | d1hwxa1 |
| not modelled | 94.4 | 13 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain
96 | d1llca1 |
| not modelled | 94.3 | 19 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
97 | d1i0za1 |
| not modelled | 94.3 | 26 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
98 | d1hyha1 |
| not modelled | 94.2 | 21 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
99 | c3donA_ |
| not modelled | 94.0 | 18 | PDB header:oxidoreductase Chain: A: PDB Molecule:shikimate dehydrogenase; PDBTitle: crystal structure of shikimate dehydrogenase from staphylococcus2 epidermidis
100 | d1bgva1 |
| not modelled | 94.0 | 15 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain
101 | d1jw9b_ |
| not modelled | 94.0 | 16 | Fold:Activating enzymes of the ubiquitin-like proteins Superfamily:Activating enzymes of the ubiquitin-like proteins Family:Molybdenum cofactor biosynthesis protein MoeB
102 | c3u62A_ |
| not modelled | 93.9 | 16 | PDB header:oxidoreductase Chain: A: PDB Molecule:shikimate dehydrogenase; PDBTitle: crystal structure of shikimate dehydrogenase from thermotoga maritima
103 | c2gcgB_ |
| not modelled | 93.9 | 17 | PDB header:oxidoreductase Chain: B: PDB Molecule:glyoxylate reductase/hydroxypyruvate reductase; PDBTitle: ternary crystal structure of human glyoxylate2 reductase/hydroxypyruvate reductase
104 | c1zfnA_ |
| not modelled | 93.9 | 16 | PDB header:transferase Chain: A: PDB Molecule:adenylyltransferase thif; PDBTitle: structural analysis of escherichia coli thif
105 | c2hk8B_ |
| not modelled | 93.9 | 24 | PDB header:oxidoreductase Chain: B: PDB Molecule:shikimate dehydrogenase; PDBTitle: crystal structure of shikimate dehydrogenase from aquifex2 aeolicus at 2.35 angstrom resolution
106 | d5ldha1 |
| not modelled | 93.8 | 24 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
107 | c2d4aC_ |
| not modelled | 93.6 | 19 | PDB header:oxidoreductase Chain: C: PDB Molecule:malate dehydrogenase; PDBTitle: structure of the malate dehydrogenase from aeropyrum pernix
108 | c1up6F_ |
| not modelled | 93.6 | 25 | PDB header:hydrolase Chain: F: PDB Molecule:6-phospho-beta-glucosidase; PDBTitle: structure of the 6-phospho-beta glucosidase from thermotoga2 maritima at 2.55 angstrom resolution in the tetragonal form3 with manganese, nad+ and glucose-6-phosphate
109 | c1vjtA_ |
| not modelled | 93.6 | 24 | PDB header:hydrolase Chain: A: PDB Molecule:alpha-glucosidase; PDBTitle: crystal structure of alpha-glucosidase (tm0752) from thermotoga2 maritima at 2.50 a resolution
110 | c1ojuA_ |
| not modelled | 93.6 | 17 | PDB header:oxidoreductase Chain: A: PDB Molecule:malate dehydrogenase; PDBTitle: 2.8 a resolution structure of malate dehydrogenase from2 archaeoglobus fulgidus in complex with etheno-nad.
111 | c1b0aA_ |
| not modelled | 93.4 | 22 | PDB header:oxidoreductase,hydrolase Chain: A: PDB Molecule:protein (fold bifunctional protein); PDBTitle: 5,10, methylene-tetrahydropholate2 dehydrogenase/cyclohydrolase from e coli.
112 | c3h9gA_ |
| not modelled | 93.4 | 14 | PDB header:transferase/antibiotic Chain: A: PDB Molecule:mccb protein; PDBTitle: crystal structure of e. coli mccb + mcca-n7isoasn
113 | c3gucB_ |
| not modelled | 93.3 | 24 | PDB header:transferase Chain: B: PDB Molecule:ubiquitin-like modifier-activating enzyme 5; PDBTitle: human ubiquitin-activating enzyme 5 in complex with amppnp
114 | c8ldhA_ |
| not modelled | 93.3 | 24 | PDB header:oxidoreductase(choh(d)-nad(a)) Chain: A: PDB Molecule:m4 apo-lactate dehydrogenase; PDBTitle: refined crystal structure of dogfish m4 apo-lactate2 dehydrogenase
115 | c1luaA_ |
| not modelled | 93.2 | 20 | PDB header:oxidoreductase Chain: A: PDB Molecule:methylene tetrahydromethanopterin dehydrogenase; PDBTitle: structure of methylene-tetrahydromethanopterin dehydrogenase from2 methylobacterium extorquens am1 complexed with nadp
116 | c1ldbA_ |
| not modelled | 93.2 | 17 | PDB header:oxidoreductase(choh(d)-nad(a)) Chain: A: PDB Molecule:apo-l-lactate dehydrogenase; PDBTitle: structure determination and refinement of bacillus2 stearothermophilus lactate dehydrogenase
117 | d1ldma1 |
| not modelled | 93.1 | 25 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
118 | d1luaa1 |
| not modelled | 93.1 | 16 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain
119 | d1mlda1 |
| not modelled | 93.0 | 19 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
120 | c3vh1A_ |
| not modelled | 93.0 | 20 | PDB header:metal binding protein Chain: A: PDB Molecule:ubiquitin-like modifier-activating enzyme atg7; PDBTitle: crystal structure of saccharomyces cerevisiae atg7 (1-595)

Binding site prediction |

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0