Secondary structure and disorder prediction

1

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10

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20

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30

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40

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50

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60

Sequence

M

K

M

T

K

L

A

T

L

F

L

T

A

T

L

S

L

A

S

G

A

A

L

A

A

D

S

G

A

Q

T

N

N

G

Q

A

N

A

A

A

D

A

G

Q

V

A

P

D

A

R

E

N

V

A

P

N

N

V

D

N

Secondary structure

SS confidence

Disorder

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Disorder confidence

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70

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80

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90

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100

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110

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120

Sequence

N

G

V

N

T

G

S

G

G

T

M

L

H

S

D

G

S

S

M

N

N

D

G

M

T

K

D

E

E

H

K

N

T

M

C

K

D

G

R

C

P

D

I

N

K

K

V

Q

T

G

D

G

I

N

N

D

V

D

T

K

Secondary structure

SS confidence

Disorder

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Disorder confidence

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Sequence

T

D

G

T

T

Q

Secondary structure

SS confidence

Disorder

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Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1yc5 chain A domain 1 Region: 1 - 28 Aligned: 28 Modelled: 28 Confidence: 25.3% Identity: 32% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Sir2 family of transcriptional regulators Phyre2 1 d1yc5a1

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1yc5a1 25.3 32 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0