Phyre 2 Results for Q06067

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Email | l.a.kelley@imperial.ac.uk
Description | Q06067
Date | Thu Jan 5 12:33:25 GMT 2012
Unique Job ID | e476e983d4dea314

Summary |

Top model
Image coloured by rainbow N → C terminus
| Close Jmol

Model (left) based on template c3a0rA_
Top template information
PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)
Confidence and coverage
Confidence: | 100.0% | Coverage: | 54%
328 residues ( 54% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
488 residues ( 80%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis |

Secondary structure and disorder prediction |

|  | 1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60
Sequence |  | M | H | Y | M | K | W | I | Y | P | R | R | L | R | N | Q | M | I | L | M | A | I | L | M | V | I | V | P | T | L | T | I | G | Y | I | V | E | T | E | G | R | S | A | V | L | S | E | K | E | K | K | L | S | A | V | V | N | L | L | N | Q
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? |  | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120
Sequence |  | A | L | G | D | R | Y | D | L | Y | I | D | L | P | R | E | E | R | I | R | A | L | N | A | E | L | A | P | I | T | E | N | I | T | H | A | F | P | G | I | G | A | G | Y | Y | N | K | M | L | D | A | I | I | T | Y | A | P | S | A | L | Y
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  | ? | ? | ? | ? |  |  |  |  |  |  | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180
Sequence |  | Q | N | N | V | G | V | T | I | A | A | D | H | P | G | R | E | V | M | R | T | N | T | P | L | V | Y | S | G | R | Q | V | R | G | D | I | L | N | S | M | L | P | I | E | R | N | G | E | I | L | G | Y | I | W | A | N | E | L | T | E | D
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? |  |  |  |  |  |  | ? | ? |  | ? | ? | ? | ? | ? |  |  | ? | ? | ? | ? |  |  | ? |  |  | ? |  |  | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240
Sequence |  | I | R | R | Q | A | W | K | M | D | V | R | I | I | I | V | L | T | A | G | L | L | I | S | L | L | L | I | V | L | F | S | R | R | L | S | A | N | I | D | I | I | T | D | G | L | S | T | L | A | Q | N | I | P | T | R | L | P | Q | L | P
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300
Sequence |  | G | E | M | G | Q | I | S | Q | S | V | N | N | L | A | Q | A | L | R | E | T | R | T | L | N | D | L | I | I | E | N | A | A | D | G | V | I | A | I | D | R | Q | G | D | V | T | T | M | N | P | A | A | E | V | I | T | G | Y | Q | R | H
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | 360
Sequence |  | E | L | V | G | Q | P | Y | S | M | L | F | D | N | T | Q | F | Y | S | P | V | L | D | T | L | E | H | G | T | E | H | V | A | L | E | I | S | F | P | G | R | D | R | T | I | E | L | S | V | T | T | S | R | I | H | N | T | H | G | E | M
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | . | . | . | . | . | . | . | . | 400 | . | . | . | . | . | . | . | . | . | 410 | . | . | . | . | . | . | . | . | . | 420
Sequence |  | I | G | A | L | V | I | F | S | D | L | T | A | R | K | E | T | Q | R | R | M | A | Q | A | E | R | L | A | T | L | G | E | L | M | A | G | V | A | H | E | V | R | N | P | L | T | A | I | R | G | Y | V | Q | I | L | R | Q | Q | T | S | D
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . | . | . | . | . | 460 | . | . | . | . | . | . | . | . | . | 470 | . | . | . | . | . | . | . | . | . | 480
Sequence |  | P | I | H | Q | E | Y | L | S | V | V | L | K | E | I | D | S | I | N | K | V | I | Q | Q | L | L | E | F | S | R | P | R | H | S | Q | W | Q | Q | V | S | L | N | A | L | V | E | E | T | L | V | L | V | Q | T | A | G | V | Q | A | R | V
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 490 | . | . | . | . | . | . | . | . | . | 500 | . | . | . | . | . | . | . | . | . | 510 | . | . | . | . | . | . | . | . | . | 520 | . | . | . | . | . | . | . | . | . | 530 | . | . | . | . | . | . | . | . | . | 540
Sequence |  | D | F | I | S | E | L | D | N | E | L | S | P | I | N | A | D | R | E | L | L | K | Q | V | L | L | N | I | L | I | N | A | V | Q | A | I | S | A | R | G | K | I | R | I | Q | T | W | Q | Y | S | D | S | Q | Q | A | I | S | I | E | D | N
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 550 | . | . | . | . | . | . | . | . | . | 560 | . | . | . | . | . | . | . | . | . | 570 | . | . | . | . | . | . | . | . | . | 580 | . | . | . | . | . | . | . | . | . | 590 | . | . | . | . | . | . | . | . | . | 600
Sequence |  | G | C | G | I | D | L | S | L | Q | K | K | I | F | D | P | F | F | T | T | K | A | S | G | T | G | L | G | L | A | L | S | Q | R | I | I | N | A | H | Q | G | D | I | R | V | A | S | L | P | G | Y | G | A | T | F | T | L | I | L | P | I
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | .
Sequence |  | N | P | Q | G | N | Q | T | V
Secondary structure |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |
Disorder |  |  | ? | ? | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |

Confidence Key
High(9) |  |  |  |  |  |  |  |  |  |  | Low (0)

? | Disordered
| Alpha helix
| Beta strand

Domain analysis |

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank | Aligned region
--- | ---
1 |
| c3a0rA_ |

### PDB 3a0r chain A

Region: 264 - 603
Aligned: 328
Modelled: 340
Confidence: 100.0%
Identity: 28%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)

Phyre2
2 |
| c3d36B_ |

### PDB 3d36 chain B

Region: 383 - 602
Aligned: 217
Modelled: 220
Confidence: 100.0%
Identity: 28%
PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:sporulation kinase b;
PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda

Phyre2
3 |
| c2q8fA_ |

### PDB 2q8f chain A

Region: 376 - 602
Aligned: 226
Modelled: 227
Confidence: 100.0%
Identity: 16%
PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1;
PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1

Phyre2
4 |
| c2bu8A_ |

### PDB 2bu8 chain A

Region: 377 - 605
Aligned: 228
Modelled: 229
Confidence: 100.0%
Identity: 17%
PDB header:transferase
Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2;
PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands

Phyre2
5 |
| c3d2rB_ |

### PDB 3d2r chain B

Region: 377 - 608
Aligned: 231
Modelled: 232
Confidence: 100.0%
Identity: 16%
PDB header:transferase
Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4;
PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp

Phyre2
6 |
| c2c2aA_ |

### PDB 2c2a chain A

Region: 367 - 602
Aligned: 229
Modelled: 236
Confidence: 100.0%
Identity: 29%
PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein

Phyre2
7 |
| c1gjvA_ |

### PDB 1gjv chain A

Region: 376 - 606
Aligned: 227
Modelled: 231
Confidence: 100.0%
Identity: 18%
PDB header:transferase
Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase
PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s

Phyre2
8 |
| c1y8oA_ |

### PDB 1y8o chain A

Region: 377 - 608
Aligned: 228
Modelled: 232
Confidence: 100.0%
Identity: 14%
PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3;
PDBTitle: crystal structure of the pdk3-l2 complex

Phyre2
9 |
| c3a0tA_ |

### PDB 3a0t chain A

Region: 453 - 604
Aligned: 151
Modelled: 152
Confidence: 100.0%
Identity: 35%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal)

Phyre2
10 |
| d2c2aa2 |

### PDB 2c2a chain A domain 2

Region: 452 - 601
Aligned: 146
Modelled: 150
Confidence: 100.0%
Identity: 29%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2
11 |
| d1gkza2 |

### PDB 1gkz chain A domain 2

Region: 458 - 606
Aligned: 147
Modelled: 149
Confidence: 100.0%
Identity: 21%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain

Phyre2
12 |
| d1jm6a2 |

### PDB 1jm6 chain A domain 2

Region: 458 - 607
Aligned: 149
Modelled: 150
Confidence: 100.0%
Identity: 19%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain

Phyre2
13 |
| d1id0a_ |

### PDB 1id0 chain A

Region: 455 - 601
Aligned: 143
Modelled: 147
Confidence: 100.0%
Identity: 24%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2
14 |
| c1b3qA_ |

### PDB 1b3q chain A

Region: 411 - 602
Aligned: 180
Modelled: 192
Confidence: 100.0%
Identity: 18%
PDB header:transferase
Chain: A: PDB Molecule:protein (chemotaxis protein chea);
PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase

Phyre2
15 |
| d1bxda_ |

### PDB 1bxd chain A

Region: 451 - 607
Aligned: 150
Modelled: 157
Confidence: 100.0%
Identity: 26%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2
16 |
| c2ch4A_ |

### PDB 2ch4 chain A

Region: 455 - 606
Aligned: 149
Modelled: 152
Confidence: 100.0%
Identity: 27%
PDB header:transferase/chemotaxis
Chain: A: PDB Molecule:chemotaxis protein chea;
PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew

Phyre2
17 |
| d1i58a_ |

### PDB 1i58 chain A

Region: 455 - 600
Aligned: 145
Modelled: 143
Confidence: 99.9%
Identity: 27%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2
18 |
| d1ysra1 |

### PDB 1ysr chain A domain 1

Region: 453 - 602
Aligned: 137
Modelled: 150
Confidence: 99.9%
Identity: 23%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2
19 |
| c3jz3B_ |

### PDB 3jz3 chain B

Region: 427 - 599
Aligned: 145
Modelled: 150
Confidence: 99.9%
Identity: 23%
PDB header:transferase
Chain: B: PDB Molecule:sensor protein qsec;
PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec

Phyre2
20 |
| d1r62a_ |

### PDB 1r62 chain A

Region: 455 - 602
Aligned: 135
Modelled: 141
Confidence: 99.9%
Identity: 28%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2
21 |
22 |
23 |
24 |
25 |
26 |
27 |
28 |
29 |
30 |
31 |
32 |
33 |
34 |
35 |
36 |
37 |
38 |
39 |
40 |
41 |
42 |
43 |
44 |
45 |
46 |
47 |
48 |
49 |
50 |
51 |
52 |
53 |
54 |
55 |
56 |
57 |
58 |
59 |
60 |
61 |
62 |
63 |
64 |
65 |
66 |
67 |
68 |
69 |
70 |
71 |
72 |
73 |
74 |
75 |
76 |
77 |
78 |
79 |
80 |
81 |
82 |
83 |
84 |
85 |
86 |
87 |
88 |
89 |
90 |
91 |
92 |
93 |
94 |
95 |
96 |
97 |
98 |
99 |
100 |
101 |
102 |
103 |
104 |
105 |
106 |
107 |
108 |
109 |
110 |
111 |
112 |
113 |
114 |
115 |
116 |
117 |
118 |
119 |
120 |
121 |
| c3by9A_ |

### PDB 3by9 chain A

Region: 37 - 183
Aligned: 146
Modelled: 145
Confidence: 96.4%
Identity: 14%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of the v. cholerae histidine kinase dctb2 sensor domain

Phyre2
122 |
| d2p7ja2 |

### PDB 2p7j chain A domain 2

Region: 41 - 185
Aligned: 145
Modelled: 143
Confidence: 96.1%
Identity: 10%
Fold: Profilin-like
Superfamily: Sensory domain-like
Family: YkuI C-terminal domain-like

Phyre2
123 |
124 |
| d1p0za_ |

### PDB 1p0z chain A

Region: 48 - 182
Aligned: 124
Modelled: 124
Confidence: 95.9%
Identity: 10%
Fold: Profilin-like
Superfamily: Sensory domain-like
Family: Sensory domain of two-component sensor kinase

Phyre2
125 |
126 |
| c3e4pB_ |

### PDB 3e4p chain B

Region: 43 - 186
Aligned: 143
Modelled: 143
Confidence: 95.6%
Identity: 16%
PDB header:transferase
Chain: B: PDB Molecule:c4-dicarboxylate transport sensor protein dctb;
PDBTitle: crystal structure of malonate occupied dctb

Phyre2
127 |
128 |
| d3by8a1 |

### PDB 3by8 chain A domain 1

Region: 46 - 186
Aligned: 130
Modelled: 130
Confidence: 94.4%
Identity: 13%
Fold: Profilin-like
Superfamily: Sensory domain-like
Family: Sensory domain of two-component sensor kinase

Phyre2
129 |
| c3fosA_ |

### PDB 3fos chain A

Region: 44 - 188
Aligned: 140
Modelled: 137
Confidence: 94.1%
Identity: 16%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of two-component sensor histidine kinase domain from2 bacillus subtilis subsp. subtilis str. 168

Phyre2
130 |
131 |
132 |
133 |
| c3lnrA_ |

### PDB 3lnr chain A

Region: 203 - 258
Aligned: 56
Modelled: 56
Confidence: 88.2%
Identity: 16%
PDB header:signaling protein
Chain: A: PDB Molecule:aerotaxis transducer aer2;
PDBTitle: crystal structure of poly-hamp domains from the p. aeruginosa soluble2 receptor aer2

Phyre2
134 |
135 |
| d2asxa1 |

### PDB 2asx chain A domain 1

Region: 213 - 259
Aligned: 47
Modelled: 47
Confidence: 86.2%
Identity: 17%
Fold: HAMP domain-like
Superfamily: HAMP domain-like
Family: HAMP domain

Phyre2
136 |
137 |
138 |
139 |
140 |
141 |
142 |
143 |
144 |
145 |
146 |
147 |
148 |
149 |
150 |
151 |
152 |
153 |
154 |

Detailed template information |

# | Template | Alignment Coverage | 3D Model | Confidence | % i.d. | Template Information
--- | --- | --- | --- | --- | --- | ---
1 | c3a0rA_ |
|  | 100.0 | 28 | PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)
2 | c3d36B_ |
|  | 100.0 | 28 | PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:sporulation kinase b; PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda
3 | c2q8fA_ |
|  | 100.0 | 16 | PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1
4 | c2bu8A_ |
|  | 100.0 | 17 | PDB header:transferase Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2; PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands
5 | c3d2rB_ |
|  | 100.0 | 16 | PDB header:transferase Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4; PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp
6 | c2c2aA_ |
|  | 100.0 | 29 | PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase; PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein
7 | c1gjvA_ |
|  | 100.0 | 18 | PDB header:transferase Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s
8 | c1y8oA_ |
|  | 100.0 | 14 | PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3; PDBTitle: crystal structure of the pdk3-l2 complex
9 | c3a0tA_ |
|  | 100.0 | 35 | PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal)
10 | d2c2aa2 |
|  | 100.0 | 29 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase
11 | d1gkza2 |
|  | 100.0 | 21 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
12 | d1jm6a2 |
|  | 100.0 | 19 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
13 | d1id0a_ |
|  | 100.0 | 24 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase
14 | c1b3qA_ |
|  | 100.0 | 18 | PDB header:transferase Chain: A: PDB Molecule:protein (chemotaxis protein chea); PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase
15 | d1bxda_ |
|  | 100.0 | 26 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase
16 | c2ch4A_ |
|  | 100.0 | 27 | PDB header:transferase/chemotaxis Chain: A: PDB Molecule:chemotaxis protein chea; PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew
17 | d1i58a_ |
|  | 99.9 | 27 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase
18 | d1ysra1 |
|  | 99.9 | 23 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase
19 | c3jz3B_ |
|  | 99.9 | 23 | PDB header:transferase Chain: B: PDB Molecule:sensor protein qsec; PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec
20 | d1r62a_ |
|  | 99.9 | 28 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase
21 | d2hkja3 |
| not modelled | 99.8 | 24 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain
22 | c3ehgA_ |
| not modelled | 99.8 | 19 | PDB header:transferase Chain: A: PDB Molecule:sensor kinase (yocf protein); PDBTitle: crystal structure of the atp-binding domain of desk in complex with2 atp
23 | c3zxqA_ |
| not modelled | 99.8 | 20 | PDB header:transferase Chain: A: PDB Molecule:hypoxia sensor histidine kinase response regulator dost; PDBTitle: crystal structure of the atp-binding domain of mycobacterium2 tuberculosis dost
24 | c2zbkB_ |
| not modelled | 99.7 | 24 | PDB header:isomerase Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b; PDBTitle: crystal structure of an intact type ii dna topoisomerase:2 insights into dna transfer mechanisms
25 | c3gieA_ |
| not modelled | 99.7 | 16 | PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase desk; PDBTitle: crystal structure of deskc_h188e in complex with amp-pcp
26 | c1mx0D_ |
| not modelled | 99.7 | 20 | PDB header:isomerase Chain: D: PDB Molecule:type ii dna topoisomerase vi subunit b; PDBTitle: structure of topoisomerase subunit
27 | c3zxoB_ |
| not modelled | 99.7 | 21 | PDB header:transferase Chain: B: PDB Molecule:redox sensor histidine kinase response regulator devs; PDBTitle: crystal structure of the mutant atp-binding domain of2 mycobacterium tuberculosis doss
28 | c2q2eB_ |
| not modelled | 99.7 | 23 | PDB header:isomerase Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b; PDBTitle: crystal structure of the topoisomerase vi holoenzyme from2 methanosarcina mazei
29 | d1h7sa2 |
| not modelled | 99.6 | 16 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain
30 | d1th8a_ |
| not modelled | 99.5 | 19 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase
31 | d1bkna2 |
| not modelled | 99.4 | 18 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain
32 | d1ixma_ |
| not modelled | 99.4 | 17 | Fold:Sporulation response regulatory protein Spo0B Superfamily:Sporulation response regulatory protein Spo0B Family:Sporulation response regulatory protein Spo0B
33 | d1b63a2 |
| not modelled | 99.4 | 23 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain
34 | d1y8oa2 |
| not modelled | 99.4 | 15 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
35 | c3na3A_ |
| not modelled | 99.1 | 22 | PDB header:protein binding Chain: A: PDB Molecule:dna mismatch repair protein mlh1; PDBTitle: mutl protein homolog 1 isoform 1 from homo sapiens
36 | c3h4lB_ |
| not modelled | 98.8 | 27 | PDB header:dna binding protein, protein binding Chain: B: PDB Molecule:dna mismatch repair protein pms1; PDBTitle: crystal structure of n terminal domain of a dna repair protein
37 | c1bknA_ |
| not modelled | 98.5 | 27 | PDB header:dna repair Chain: A: PDB Molecule:mutl; PDBTitle: crystal structure of an n-terminal 40kd fragment of e. coli2 dna mismatch repair protein mutl
38 | c1kijB_ |
| not modelled | 98.5 | 22 | PDB header:isomerase Chain: B: PDB Molecule:dna gyrase subunit b; PDBTitle: crystal structure of the 43k atpase domain of thermus thermophilus2 gyrase b in complex with novobiocin
39 | c1ei1B_ |
| not modelled | 98.4 | 18 | PDB header:isomerase Chain: B: PDB Molecule:dna gyrase b; PDBTitle: dimerization of e. coli dna gyrase b provides a structural mechanism2 for activating the atpase catalytic center
40 | c2v1bA_ |
| not modelled | 98.4 | 14 | PDB header:transferase Chain: A: PDB Molecule:nph1-1; PDBTitle: n- and c-terminal helices of oat lov2 (404-546) are2 involved in light-induced signal transduction (room3 temperature (293k) light structure of lov2 (404-546))
41 | d1kija2 |
| not modelled | 98.4 | 23 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain
42 | d1pvga2 |
| not modelled | 98.3 | 20 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain
43 | c1ea6A_ |
| not modelled | 98.3 | 18 | PDB header:dna repair Chain: A: PDB Molecule:pms1 protein homolog 2; PDBTitle: n-terminal 40kda fragment of nhpms2 complexed with adp
44 | c2wkqA_ |
| not modelled | 98.3 | 13 | PDB header:transferase, cell adhesion Chain: A: PDB Molecule:nph1-1, ras-related c3 botulinum toxin substrate PDBTitle: structure of a photoactivatable rac1 containing the lov22 c450a mutant
45 | c3lyxA_ |
| not modelled | 98.3 | 24 | PDB header:transcription Chain: A: PDB Molecule:sensory box/ggdef domain protein; PDBTitle: crystal structure of the pas domain of the protein cps_12912 from colwellia psychrerythraea. northeast structural3 genomics consortium target id csr222b
46 | d1s16a2 |
| not modelled | 98.3 | 16 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain
47 | c2gj3A_ |
| not modelled | 98.3 | 20 | PDB header:transferase Chain: A: PDB Molecule:nitrogen fixation regulatory protein; PDBTitle: crystal structure of the fad-containing pas domain of the2 protein nifl from azotobacter vinelandii.
48 | d1ei1a2 |
| not modelled | 98.3 | 18 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain
49 | c3luqC_ |
| not modelled | 98.3 | 16 | PDB header:transferase Chain: C: PDB Molecule:sensor protein; PDBTitle: the crystal structure of a pas domain from a sensory box2 histidine kinase regulator from geobacter sulfurreducens to3 2.5a
50 | c1y4sA_ |
| not modelled | 98.2 | 24 | PDB header:chaperone Chain: A: PDB Molecule:chaperone protein htpg; PDBTitle: conformation rearrangement of heat shock protein 90 upon2 adp binding
51 | c3ke6A_ |
| not modelled | 98.2 | 25 | PDB header:unknown function Chain: A: PDB Molecule:protein rv1364c/mt1410; PDBTitle: the crystal structure of the rsbu and rsbw domains of rv1364c from2 mycobacterium tuberculosis
52 | d1bywa_ |
| not modelled | 98.1 | 16 | Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:Flavin-binding PAS domain
53 | c1s16B_ |
| not modelled | 98.1 | 15 | PDB header:isomerase Chain: B: PDB Molecule:topoisomerase iv subunit b; PDBTitle: crystal structure of e. coli topoisomerase iv pare 43kda subunit2 complexed with adpnp
54 | d1n9la_ |
| not modelled | 98.1 | 14 | Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:Flavin-binding PAS domain
55 | c3caxA_ |
| not modelled | 98.0 | 15 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein pf0695; PDBTitle: crystal structure of uncharacterized protein pf0695
56 | c2cg9A_ |
| not modelled | 98.0 | 24 | PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: crystal structure of an hsp90-sba1 closed chaperone complex
57 | c2iopD_ |
| not modelled | 98.0 | 25 | PDB header:chaperone Chain: D: PDB Molecule:chaperone protein htpg; PDBTitle: crystal structure of full-length htpg, the escherichia coli2 hsp90, bound to adp
58 | c3b33A_ |
| not modelled | 98.0 | 23 | PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of the pas domain of nitrogen regulation protein2 nr(ii) from vibrio parahaemolyticus
59 | c2o1wB_ |
| not modelled | 98.0 | 22 | PDB header:chaperone Chain: B: PDB Molecule:endoplasmin; PDBTitle: structure of n-terminal plus middle domains (n+m) of grp94
60 | c3g7bB_ |
| not modelled | 98.0 | 21 | PDB header:isomerase Chain: B: PDB Molecule:dna gyrase subunit b; PDBTitle: staphylococcus aureus gyrase b co-complex with inhibitor
61 | c3mqoB_ |
| not modelled | 98.0 | 15 | PDB header:transcription regulator Chain: B: PDB Molecule:transcriptional regulator, luxr family; PDBTitle: the crystal structure of the pas domain in complex with isopropanol of2 a transcriptional regulator in the luxr family from burkholderia3 thailandensis to 1.7a
62 | c2l4rA_ |
| not modelled | 98.0 | 16 | PDB header:transport protein Chain: A: PDB Molecule:potassium voltage-gated channel subfamily h member 2; PDBTitle: nmr solution structure of the n-terminal pas domain of herg
63 | c1zxnB_ |
| not modelled | 97.9 | 31 | PDB header:isomerase Chain: B: PDB Molecule:dna topoisomerase ii, alpha isozyme; PDBTitle: human dna topoisomerase iia atpase/adp
64 | c3iedA_ |
| not modelled | 97.9 | 28 | PDB header:chaperone Chain: A: PDB Molecule:heat shock protein; PDBTitle: crystal structure of n-terminal domain of plasmodium falciparum hsp902 (pf14_0417) in complex with amppn
65 | d1jnua_ |
| not modelled | 97.9 | 10 | Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:Flavin-binding PAS domain
66 | c2fwyA_ |
| not modelled | 97.9 | 13 | PDB header:chaperone Chain: A: PDB Molecule:heat shock protein hsp 90-alpha; PDBTitle: structure of human hsp90-alpha bound to the potent water2 soluble inhibitor pu-h64
67 | c3pehB_ |
| not modelled | 97.9 | 22 | PDB header:chaperone Chain: B: PDB Molecule:endoplasmin homolog; PDBTitle: crystal structure of the n-terminal domain of an hsp90 from plasmodium2 falciparum, pfl1070c in the presence of a thienopyrimidine derivative
68 | d1uyla_ |
| not modelled | 97.9 | 16 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain
69 | c2vlgD_ |
| not modelled | 97.9 | 6 | PDB header:transferase Chain: D: PDB Molecule:sporulation kinase a; PDBTitle: kina pas-a domain, homodimer
70 | c2z6dB_ |
| not modelled | 97.9 | 14 | PDB header:transferase Chain: B: PDB Molecule:phototropin-2; PDBTitle: crystal structure of lov1 domain of phototropin2 from2 arabidopsis thaliana
71 | c3mxqC_ |
| not modelled | 97.9 | 13 | PDB header:transferase Chain: C: PDB Molecule:sensor protein; PDBTitle: crystal structure of sensory box sensor histidine kinase from vibrio2 cholerae
72 | c3mfxA_ |
| not modelled | 97.8 | 12 | PDB header:transcription Chain: A: PDB Molecule:sensory box/ggdef family protein; PDBTitle: crystal structure of the sensory box domain of the sensory-2 box/ggdef protein so_1695 from shewanella oneidensis,3 northeast structural genomics consortium target sor288b
73 | c2iorA_ |
| not modelled | 97.8 | 23 | PDB header:chaperone Chain: A: PDB Molecule:chaperone protein htpg; PDBTitle: crystal structure of the n-terminal domain of htpg, the2 escherichia coli hsp90, bound to adp
74 | c2akpA_ |
| not modelled | 97.8 | 16 | PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: hsp90 delta24-n210 mutant
75 | c3a0vA_ |
| not modelled | 97.8 | 17 | PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: pas domain of histidine kinase thka (tm1359) (semet,2 f486m/f489m)
76 | c3f1oB_ |
| not modelled | 97.8 | 10 | PDB header:transcription Chain: B: PDB Molecule:aryl hydrocarbon receptor nuclear translocator; PDBTitle: crystal structure of the high affinity heterodimer of hif22 alpha and arnt c-terminal pas domains, with an internally-3 bound artificial ligand
77 | c1qzrA_ |
| not modelled | 97.8 | 21 | PDB header:isomerase Chain: A: PDB Molecule:dna topoisomerase ii; PDBTitle: crystal structure of the atpase region of saccharomyces cerevisiae2 topoisomerase ii bound to icrf-187 (dexrazoxane)
78 | d2iwxa1 |
| not modelled | 97.8 | 16 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain
79 | d2gqpa1 |
| not modelled | 97.8 | 14 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain
80 | c1zwhA_ |
| not modelled | 97.7 | 16 | PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: yeast hsp82 in complex with the novel hsp90 inhibitor radester amine
81 | d1v9ya_ |
| not modelled | 97.7 | 20 | Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:Heme-binding PAS domain
82 | c1v9yA_ |
| not modelled | 97.7 | 20 | PDB header:signaling protein Chain: A: PDB Molecule:heme pas sensor protein; PDBTitle: crystal structure of the heme pas sensor domain of ec dos (ferric2 form)
83 | c3fg8B_ |
| not modelled | 97.7 | 17 | PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein rha05790; PDBTitle: crystal structure of pas domain of rha05790
84 | d1s14a_ |
| not modelled | 97.7 | 22 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain
85 | d1p97a_ |
| not modelled | 97.7 | 10 | Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:Hypoxia-inducible factor Hif2a, C-terminal domain
86 | c2pr6A_ |
| not modelled | 97.7 | 13 | PDB header:flavoprotein, signaling protein Chain: A: PDB Molecule:blue-light photoreceptor; PDBTitle: structural basis for light-dependent signaling in the dimeric lov2 photosensor ytva (light structure)
87 | c2qkpD_ |
| not modelled | 97.7 | 10 | PDB header:structural genomics, unknown function Chain: D: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of c-terminal domain of smu_1151c from streptococcus2 mutans
88 | c3k3dA_ |
| not modelled | 97.6 | 9 | PDB header:signaling protein Chain: A: PDB Molecule:protein rv1364c/mt1410; PDBTitle: the n-terminal pas domain crystal structure of rv1364c from2 mycobacterium tuberculosis at 2.3 angstrom
89 | c3mjqB_ |
| not modelled | 97.6 | 17 | PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of the pas domain of q24qt8_deshy protein from2 desulfitobacterium hafniense. northeast structural genomics3 consortium target dhr85c.
90 | c3eehA_ |
| not modelled | 97.6 | 17 | PDB header:transferase Chain: A: PDB Molecule:putative light and redox sensing histidine kinase; PDBTitle: the crystal structure of the domain of the putative light and redox2 sensing histidine kinase from haloarcula marismortui
91 | c2kdkA_ |
| not modelled | 97.6 | 15 | PDB header:transcription regulator Chain: A: PDB Molecule:aryl hydrocarbon receptor nuclear translocator-like protein PDBTitle: structure of human circadian clock protein bmal2 c-terminal pas domain
92 | c3kx0X_ |
| not modelled | 97.6 | 12 | PDB header:signaling protein Chain: X: PDB Molecule:uncharacterized protein rv1364c/mt1410; PDBTitle: crystal structure of the pas domain of rv1364c
93 | c3h9wA_ |
| not modelled | 97.5 | 11 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:diguanylate cyclase with pas/pac sensor; PDBTitle: crystal structure of the n-terminal domain of diguanylate cyclase with2 pas/pac sensor (maqu_2914) from marinobacter aquaeolei, northeast3 structural genomics consortium target mqr66c
94 | c3mr0B_ |
| not modelled | 97.5 | 16 | PDB header:transcription regulator Chain: B: PDB Molecule:sensory box histidine kinase/response regulator; PDBTitle: crystal structure of sensory box histidine kinase/response regulator2 from burkholderia thailandensis e264
95 | d1uyma_ |
| not modelled | 97.5 | 16 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain
96 | c1wa9A_ |
| not modelled | 97.4 | 10 | PDB header:circadian rhythm Chain: A: PDB Molecule:period circadian protein; PDBTitle: crystal structure of the pas repeat region of the2 drosophila clock protein period
97 | c3oloB_ |
| not modelled | 97.4 | 12 | PDB header:transferase Chain: B: PDB Molecule:two-component sensor histidine kinase; PDBTitle: crystal structure of a pas domain from two-component sensor histidine2 kinase
98 | d1y28a_ |
| not modelled | 97.4 | 20 | Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:Heme-binding PAS domain
99 | c2r78D_ |
| not modelled | 97.4 | 18 | PDB header:transferase Chain: D: PDB Molecule:sensor protein; PDBTitle: crystal structure of a domain of the sensory box sensor2 histidine kinase/response regulator from geobacter3 sulfurreducens
100 | d1xj3a1 |
| not modelled | 97.4 | 19 | Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:Heme-binding PAS domain
101 | c2o1uA_ |
| not modelled | 97.4 | 21 | PDB header:chaperone Chain: A: PDB Molecule:endoplasmin; PDBTitle: structure of full length grp94 with amp-pnp bound
102 | d1ew0a_ |
| not modelled | 97.4 | 14 | Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:Heme-binding PAS domain
103 | d1qy5a_ |
| not modelled | 97.4 | 18 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain
104 | c3fc7B_ |
| not modelled | 97.4 | 16 | PDB header:transferase Chain: B: PDB Molecule:htr-like protein; PDBTitle: the crystal structure of a domain of htr-like protein from haloarcula2 marismortui atcc 43049
105 | c3lnuA_ |
| not modelled | 97.3 | 17 | PDB header:isomerase Chain: A: PDB Molecule:topoisomerase iv subunit b; PDBTitle: crystal structure of pare subunit
106 | d1nwza_ |
| not modelled | 97.3 | 21 | Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:PYP-like
107 | d1mzua_ |
| not modelled | 97.3 | 13 | Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:PYP-like
108 | d1otda_ |
| not modelled | 97.2 | 20 | Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:PYP-like
109 | c2pdtD_ |
| not modelled | 97.2 | 14 | PDB header:circadian clock protein Chain: D: PDB Molecule:vivid pas protein vvd; PDBTitle: 2.3 angstrom structure of phosphodiesterase treated vivid
110 | c3p7nB_ |
| not modelled | 97.2 | 12 | PDB header:dna binding protein Chain: B: PDB Molecule:sensor histidine kinase; PDBTitle: crystal structure of light activated transcription factor el222 from2 erythrobacter litoralis
111 | c3bwlA_ |
| not modelled | 97.2 | 16 | PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of pas domain of htr-like protein from haloarcula2 marismortui
112 | c3rtyA_ |
| not modelled | 97.1 | 13 | PDB header:circadian clock protein Chain: A: PDB Molecule:period circadian protein; PDBTitle: structure of an enclosed dimer formed by the drosophila period protein
113 | c2jheB_ |
| not modelled | 96.9 | 14 | PDB header:transcription Chain: B: PDB Molecule:transcription regulator tyrr; PDBTitle: n-terminal domain of tyrr transcription factor (residues 1 -2 190)
114 | c3njaC_ |
| not modelled | 96.9 | 12 | PDB header:structural genomics, unknown function Chain: C: PDB Molecule:probable ggdef family protein; PDBTitle: the crystal structure of the pas domain of a ggdef family protein from2 chromobacterium violaceum atcc 12472.
115 | c3ewkA_ |
| not modelled | 96.8 | 21 | PDB header:flavoprotein Chain: A: PDB Molecule:sensor protein; PDBTitle: structure of the redox sensor domain of methylococcus capsulatus2 (bath) mmos
116 | c2w0nA_ |
| not modelled | 96.7 | 19 | PDB header:transferase Chain: A: PDB Molecule:sensor protein dcus; PDBTitle: plasticity of pas domain and potential role for signal2 transduction in the histidine-kinase dcus
117 | d1xfna1 |
| not modelled | 96.7 | 20 | Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:PYP-like
118 | c3icyB_ |
| not modelled | 96.7 | 9 | PDB header:structural genomics, unknown function Chain: B: PDB Molecule:sensor protein; PDBTitle: the crystal structure of sensory box histidine2 kinase/response regulator domain from chlorobium tepidum3 tls
119 | d1oj5a_ |
| not modelled | 96.6 | 9 | Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:PAS domain of steroid receptor coactivator 1A, NCo-A1
120 | c3gecA_ |
| not modelled | 96.6 | 11 | PDB header:circadian clock protein Chain: A: PDB Molecule:period circadian protein; PDBTitle: crystal structure of a tandem pas domain fragment of2 drosophila period

Binding site prediction |

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0