Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	Q	L	T	H	I	N	A	A	G	E	A	H	M	V	D	V	S	A	K	A	E	T	V	R	E	A	R	A	E	A	F	V	T	M	R	S	E	T	L	A	M	I	I	D	G	R	H	H	K	G	D	V	F	A	T	A	R	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																							?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	G	I	Q	A	A	K	R	T	W	D	L	I	P	L	C	H	P	L	M	L	S	K	V	E	V	N	L	Q	A	E	P	E	H	N	R	V	R	I	E	T	L	C	R	L	T	G	K	T	G	V	E	M	E	A	L	T	A	A	S
Secondary structure
SS confidence
Disorder																																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.
Sequence		V	A	A	L	T	I	Y	D	M	C	K	A	V	Q	K	D	M	V	I	G	P	V	R	L	L	A	K	S	G	G	K	S	G	D	F	K	V	E	A	D	D
Secondary structure
SS confidence
Disorder																?															?	?	?	?	?	?		?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2eey chain A Region: 2 - 159 Aligned: 158 Modelled: 158 Confidence: 100.0% Identity: 50% PDB header:biosynthetic protein Chain: A: PDB Molecule:molybdopterin biosynthesis; PDBTitle: structure of gk0241 protein from geobacillus kaustophilus Phyre2 PDB 2ide chain E Region: 11 - 157 Aligned: 147 Modelled: 147 Confidence: 100.0% Identity: 54% PDB header:biosynthetic protein Chain: E: PDB Molecule:molybdenum cofactor biosynthesis protein c; PDBTitle: crystal structure of the molybdenum cofactor biosynthesis protein c2 (ttha1789) from thermus theromophilus hb8 Phyre2 PDB 1ekr chain A Region: 11 - 156 Aligned: 143 Modelled: 146 Confidence: 100.0% Identity: 100% Fold: Ferredoxin-like Superfamily: Molybdenum cofactor biosynthesis protein C, MoaC Family: Molybdenum cofactor biosynthesis protein C, MoaC Phyre2 PDB 2ekn chain C Region: 13 - 152 Aligned: 138 Modelled: 140 Confidence: 100.0% Identity: 41% PDB header:biosynthetic protein Chain: C: PDB Molecule:probable molybdenum cofactor biosynthesis protein c; PDBTitle: structure of ph1811 protein from pyrococcus horikoshii Phyre2 PDB 2ohd chain B Region: 13 - 146 Aligned: 132 Modelled: 134 Confidence: 100.0% Identity: 45% PDB header:biosynthetic protein Chain: B: PDB Molecule:probable molybdenum cofactor biosynthesis protein c; PDBTitle: crystal structure of hypothetical molybdenum cofactor biosynthesis2 protein c from sulfolobus tokodaii Phyre2 PDB 1sfe chain A Region: 36 - 79 Aligned: 41 Modelled: 44 Confidence: 37.0% Identity: 15% PDB header:dna-binding protein Chain: A: PDB Molecule:ada o6-methylguanine-dna methyltransferase; PDBTitle: ada o6-methylguanine-dna methyltransferase from escherichia coli Phyre2 PDB 1oh4 chain A Region: 137 - 150 Aligned: 14 Modelled: 14 Confidence: 33.7% Identity: 43% Fold: Galactose-binding domain-like Superfamily: Galactose-binding domain-like Family: Family 27 carbohydrate binding module, CBM27 Phyre2 PDB 3ct5 chain A Region: 15 - 65 Aligned: 40 Modelled: 51 Confidence: 31.7% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:morphogenesis protein 1; PDBTitle: crystal and cryoem structural studies of a cell wall degrading enzyme2 in the bacteriophage phi29 tail Phyre2 PDB 2cqa chain A domain 1 Region: 23 - 55 Aligned: 33 Modelled: 33 Confidence: 22.5% Identity: 15% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: TIP49 domain Phyre2 PDB 1bu2 chain A domain 2 Region: 65 - 81 Aligned: 17 Modelled: 17 Confidence: 14.8% Identity: 47% Fold: Cyclin-like Superfamily: Cyclin-like Family: Cyclin Phyre2 PDB 2b5l chain C Region: 147 - 159 Aligned: 13 Modelled: 13 Confidence: 13.0% Identity: 31% PDB header:protein binding/viral protein Chain: C: PDB Molecule:nonstructural protein v; PDBTitle: crystal structure of ddb1 in complex with simian virus 5 v2 protein Phyre2 PDB 1vqo chain N domain 1 Region: 10 - 71 Aligned: 62 Modelled: 62 Confidence: 11.1% Identity: 15% Fold: Ribonuclease H-like motif Superfamily: Translational machinery components Family: Ribosomal protein L18 and S11 Phyre2 PDB 3pn1 chain A Region: 31 - 67 Aligned: 37 Modelled: 37 Confidence: 10.3% Identity: 19% PDB header:ligase/ligase inhibitor Chain: A: PDB Molecule:dna ligase; PDBTitle: novel bacterial nad+-dependent dna ligase inhibitors with broad2 spectrum potency and antibacterial efficacy in vivo Phyre2 PDB 2p0x chain A Region: 124 - 131 Aligned: 8 Modelled: 8 Confidence: 9.2% Identity: 75% PDB header:de novo protein Chain: A: PDB Molecule:abiotic atp-binding, folding optimized protein; PDBTitle: solution structure of a non-biological atp-binding protein Phyre2 PDB 3bdq chain B Region: 6 - 64 Aligned: 59 Modelled: 59 Confidence: 9.0% Identity: 24% PDB header:lipid transport Chain: B: PDB Molecule:sterol carrier protein 2-like 2; PDBTitle: room tempreture crystal structure of sterol carrier protein-2 2 like-2 Phyre2 PDB 2xuv chain B Region: 36 - 81 Aligned: 41 Modelled: 46 Confidence: 8.8% Identity: 22% PDB header:unknown function Chain: B: PDB Molecule:hdeb; PDBTitle: the structure of hdeb Phyre2 PDB 1ikt chain A Region: 16 - 64 Aligned: 49 Modelled: 49 Confidence: 8.1% Identity: 14% Fold: SCP-like Superfamily: SCP-like Family: Sterol carrier protein, SCP Phyre2 PDB 2f1f chain A domain 2 Region: 12 - 59 Aligned: 41 Modelled: 48 Confidence: 7.9% Identity: 20% Fold: Ferredoxin-like Superfamily: ACT-like Family: IlvH-like Phyre2 PDB 2xsk chain A Region: 73 - 104 Aligned: 29 Modelled: 32 Confidence: 7.7% Identity: 28% PDB header:chaperone Chain: A: PDB Molecule:csgc; PDBTitle: e. coli curli protein csgc - secys Phyre2 PDB 2gp4 chain A domain 1 Region: 16 - 55 Aligned: 40 Modelled: 40 Confidence: 7.6% Identity: 25% Fold: The "swivelling" beta/beta/alpha domain Superfamily: LeuD/IlvD-like Family: IlvD/EDD C-terminal domain-like Phyre2 1 c2eeyA_ 2 c2ideE_ 3 d1ekra_ 4 c2eknC_ 5 c2ohdB_ 6 c1sfeA_ 7 d1oh4a_ 8 c3ct5A_ 9 d2cqaa1 10 d1bu2a2 11 c2b5lC_ 12 d1vqon1 13 c3pn1A_ 14 c2p0xA_ 15 c3bdqB_ 16 c2xuvB_ 17 d1ikta_ 18 d2f1fa2 19 c2xskA_ 20 d2gp4a1 21 22 23 24 25 26 27 28 29 30 31 32 33

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2eeyA_ 100.0 50 PDB header:biosynthetic protein Chain: A: PDB Molecule:molybdopterin biosynthesis; PDBTitle: structure of gk0241 protein from geobacillus kaustophilus 2 c2ideE_ 100.0 54 PDB header:biosynthetic protein Chain: E: PDB Molecule:molybdenum cofactor biosynthesis protein c; PDBTitle: crystal structure of the molybdenum cofactor biosynthesis protein c2 (ttha1789) from thermus theromophilus hb8 3 d1ekra_ 100.0 100 Fold:Ferredoxin-like Superfamily:Molybdenum cofactor biosynthesis protein C, MoaC Family:Molybdenum cofactor biosynthesis protein C, MoaC 4 c2eknC_ 100.0 41 PDB header:biosynthetic protein Chain: C: PDB Molecule:probable molybdenum cofactor biosynthesis protein c; PDBTitle: structure of ph1811 protein from pyrococcus horikoshii 5 c2ohdB_ 100.0 45 PDB header:biosynthetic protein Chain: B: PDB Molecule:probable molybdenum cofactor biosynthesis protein c; PDBTitle: crystal structure of hypothetical molybdenum cofactor biosynthesis2 protein c from sulfolobus tokodaii 6 c1sfeA_ 37.0 15 PDB header:dna-binding protein Chain: A: PDB Molecule:ada o6-methylguanine-dna methyltransferase; PDBTitle: ada o6-methylguanine-dna methyltransferase from escherichia coli 7 d1oh4a_ 33.7 43 Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:Family 27 carbohydrate binding module, CBM27 8 c3ct5A_ 31.7 30 PDB header:hydrolase Chain: A: PDB Molecule:morphogenesis protein 1; PDBTitle: crystal and cryoem structural studies of a cell wall degrading enzyme2 in the bacteriophage phi29 tail 9 d2cqaa1 22.5 15 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:TIP49 domain 10 d1bu2a2 14.8 47 Fold:Cyclin-like Superfamily:Cyclin-like Family:Cyclin 11 c2b5lC_ 13.0 31 PDB header:protein binding/viral protein Chain: C: PDB Molecule:nonstructural protein v; PDBTitle: crystal structure of ddb1 in complex with simian virus 5 v2 protein 12 d1vqon1 11.1 15 Fold:Ribonuclease H-like motif Superfamily:Translational machinery components Family:Ribosomal protein L18 and S11 13 c3pn1A_ 10.3 19 PDB header:ligase/ligase inhibitor Chain: A: PDB Molecule:dna ligase; PDBTitle: novel bacterial nad+-dependent dna ligase inhibitors with broad2 spectrum potency and antibacterial efficacy in vivo 14 c2p0xA_ 9.2 75 PDB header:de novo protein Chain: A: PDB Molecule:abiotic atp-binding, folding optimized protein; PDBTitle: solution structure of a non-biological atp-binding protein 15 c3bdqB_ 9.0 24 PDB header:lipid transport Chain: B: PDB Molecule:sterol carrier protein 2-like 2; PDBTitle: room tempreture crystal structure of sterol carrier protein-2 2 like-2 16 c2xuvB_ 8.8 22 PDB header:unknown function Chain: B: PDB Molecule:hdeb; PDBTitle: the structure of hdeb 17 d1ikta_ 8.1 14 Fold:SCP-like Superfamily:SCP-like Family:Sterol carrier protein, SCP 18 d2f1fa2 7.9 20 Fold:Ferredoxin-like Superfamily:ACT-like Family:IlvH-like 19 c2xskA_ 7.7 28 PDB header:chaperone Chain: A: PDB Molecule:csgc; PDBTitle: e. coli curli protein csgc - secys 20 d2gp4a1 7.6 25 Fold:The "swivelling" beta/beta/alpha domain Superfamily:LeuD/IlvD-like Family:IlvD/EDD C-terminal domain-like 21 d2bbya_ not modelled 7.1 4 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:DNA-binding domain from rap30 22 c2ketA_ not modelled 7.1 45 PDB header:antibiotic Chain: A: PDB Molecule:cathelicidin-6; PDBTitle: solution structure of bmap-27 23 c2kc5A_ not modelled 7.0 13 PDB header:chaperone Chain: A: PDB Molecule:hydrogenase-2 operon protein hybe; PDBTitle: solution structure of hybe from escherichia coli 24 d1pz4a_ not modelled 6.9 23 Fold:SCP-like Superfamily:SCP-like Family:Sterol carrier protein, SCP 25 c1z4hA_ not modelled 6.9 32 PDB header:protein binding, dna binding protein Chain: A: PDB Molecule:tor inhibition protein; PDBTitle: the response regulator tori belongs to a new family of2 atypical excisionase 26 d1vlfn1 not modelled 6.8 29 Fold:Prealbumin-like Superfamily:Cna protein B-type domain Family:Cna protein B-type domain 27 c2p09A_ not modelled 6.7 75 PDB header:de novo protein Chain: A: PDB Molecule:a non-biological atp binding protein with two mutations PDBTitle: structural insights into the evolution of a non-biological protein 28 d1wzua1 not modelled 6.4 38 Fold:NadA-like Superfamily:NadA-like Family:NadA-like 29 d1uufa2 not modelled 6.1 20 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 30 d4bcla_ not modelled 5.9 23 Fold:Bacteriochlorophyll A protein Superfamily:Bacteriochlorophyll A protein Family:Bacteriochlorophyll A protein 31 c2gp4A_ not modelled 5.8 25 PDB header:lyase Chain: A: PDB Molecule:6-phosphogluconate dehydratase; PDBTitle: structure of [fes]cluster-free apo form of 6-phosphogluconate2 dehydratase from shewanella oneidensis 32 d1juva_ not modelled 5.7 9 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 33 d1cq3a_ not modelled 5.2 83 Fold:Soluble secreted chemokine inhibitor, VCCI Superfamily:Soluble secreted chemokine inhibitor, VCCI Family:Soluble secreted chemokine inhibitor, VCCI

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0