BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (523 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_A6T4L9 2-isopropylmalate synthase n=327 Tax=Bacteria Re... 1024 0.0 UniRef50_B2VDA7 2-isopropylmalate synthase n=4 Tax=Enterobacteri... 907 0.0 UniRef50_P48571 2-isopropylmalate synthase n=3 Tax=Buchnera aphi... 756 0.0 UniRef50_Q3AEQ5 2-isopropylmalate synthase n=42 Tax=Bacteria Rep... 511 e-143 UniRef50_B6YRN0 2-isopropylmalate synthase n=1 Tax=Candidatus Az... 477 e-133 UniRef50_Q7UI51 2-isopropylmalate synthase n=1 Tax=Rhodopirellul... 475 e-132 UniRef50_B8DM91 2-isopropylmalate synthase n=31 Tax=Bacteria Rep... 474 e-132 UniRef50_Q2YBW0 2-isopropylmalate synthase n=2 Tax=Bacteria RepI... 470 e-131 UniRef50_A6LDN1 2-isopropylmalate synthase n=6 Tax=Bacteria RepI... 466 e-130 UniRef50_B3DX88 2-isopropylmalate synthase n=12 Tax=Bacteria Rep... 459 e-127 UniRef50_B8J824 2-isopropylmalate synthase n=7 Tax=Bacteria RepI... 455 e-126 UniRef50_B8J4F8 2-isopropylmalate synthase n=3 Tax=Desulfovibrio... 451 e-125 UniRef50_Q2IUT4 2-isopropylmalate synthase n=119 Tax=Bacteria Re... 447 e-124 UniRef50_A6EER4 2-isopropylmalate synthase n=3 Tax=Sphingobacter... 445 e-123 UniRef50_A4YZ76 2-isopropylmalate synthase n=131 Tax=root RepID=... 445 e-123 UniRef50_A8FFW5 2-isopropylmalate synthase n=224 Tax=Bacilli Rep... 442 e-122 UniRef50_Q5F8D4 2-isopropylmalate synthase n=73 Tax=cellular org... 441 e-122 UniRef50_B7GH19 2-isopropylmalate synthase n=98 Tax=cellular org... 441 e-122 UniRef50_UPI0001C31767 2-isopropylmalate synthase n=1 Tax=Conexi... 439 e-121 UniRef50_A3PDH0 2-isopropylmalate synthase n=42 Tax=cellular org... 439 e-121 UniRef50_A8V4T9 2-isopropylmalate synthase (Fragment) n=2 Tax=ce... 439 e-121 UniRef50_D2M1E9 2-isopropylmalate synthase n=1 Tax=Bacillus cell... 435 e-120 UniRef50_A7Z7B8 2-isopropylmalate synthase n=11 Tax=Bacillales R... 431 e-119 UniRef50_Q2S0M7 2-isopropylmalate synthase n=3 Tax=Bacteria RepI... 430 e-119 UniRef50_Q72JC9 2-isopropylmalate synthase n=4 Tax=Thermaceae Re... 421 e-116 UniRef50_D0MYD7 2-isopropylmalate synthase n=2 Tax=Phytophthora ... 415 e-114 UniRef50_A2C859 2-isopropylmalate synthase n=16 Tax=Bacteria Rep... 415 e-114 UniRef50_A3DF94 2-isopropylmalate synthase n=3 Tax=Clostridium t... 410 e-113 UniRef50_C7JAV8 2-isopropylmalate synthase n=8 Tax=Acetobacter p... 407 e-112 UniRef50_Q9C550 2-isopropylmalate synthase 2, chloroplastic n=59... 402 e-110 UniRef50_B4SI67 2-isopropylmalate synthase n=45 Tax=Xanthomonada... 397 e-109 UniRef50_Q1ARE2 2-isopropylmalate synthase n=1 Tax=Rubrobacter x... 395 e-108 UniRef50_C0Z635 Probable 2-isopropylmalate synthase n=1 Tax=Brev... 393 e-108 UniRef50_A9KRN2 2-isopropylmalate synthase n=8 Tax=Bacteria RepI... 392 e-107 UniRef50_C6CVJ5 2-isopropylmalate synthase n=2 Tax=Bacillales Re... 379 e-103 UniRef50_Q9LPR4 2-isopropylmalate synthase 1, chloroplastic n=39... 368 e-100 UniRef50_Q0AT07 2-isopropylmalate synthase n=3 Tax=Alphaproteoba... 359 1e-97 UniRef50_D2MJY3 2-isopropylmalate synthase n=1 Tax=Candidatus Po... 353 1e-95 UniRef50_C5SF21 Pyruvate carboxyltransferase n=1 Tax=Asticcacaul... 349 2e-94 UniRef50_O27525 2-isopropylmalate synthase 2 n=22 Tax=Archaea Re... 347 6e-94 UniRef50_C6PDK4 Pyruvate carboxyltransferase n=1 Tax=Thermoanaer... 334 6e-90 UniRef50_Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic ... 325 2e-87 UniRef50_UPI0001C41E20 2-isopropylmalate synthase LeuA n=1 Tax=M... 308 3e-82 UniRef50_B1MVR2 2-isopropylmalate synthase n=1 Tax=Leuconostoc c... 308 3e-82 UniRef50_D2RHN2 Isopropylmalate/citramalate/homocitratesynthase ... 301 3e-80 UniRef50_P58968 2-isopropylmalate synthase 2 n=19 Tax=Archaea Re... 298 3e-79 UniRef50_Q58787 (R)-citramalate synthase n=5 Tax=Methanococcales... 298 3e-79 UniRef50_A8HXS9 Isopropylmalate synthase (Fragment) n=1 Tax=Chla... 298 3e-79 UniRef50_A8TGZ1 Isopropylmalate/citramalate/homocitrate synthase... 286 2e-75 UniRef50_Q6T1C1 2-isopropylmalate synthase (Fragment) n=1 Tax=Xe... 286 2e-75 UniRef50_O26819 (R)-citramalate synthase n=20 Tax=Archaea RepID=... 285 4e-75 UniRef50_A8AB61 2-isopropylmalate synthase n=25 Tax=Archaea RepI... 276 1e-72 UniRef50_Q8KTR5 Alpha-isopropylmalate synthase n=14 Tax=Candidat... 276 1e-72 UniRef50_UPI0001C42034 citramalate synthase CimA n=1 Tax=Methano... 270 1e-70 UniRef50_A6VFV4 Isopropylmalate/citramalate/homocitrate synthase... 270 1e-70 UniRef50_C1ZKW9 Isopropylmalate/homocitrate/citramalate synthase... 265 3e-69 UniRef50_Q18KM5 2-isopropylmalate synthase n=9 Tax=Euryarchaeota... 254 5e-66 UniRef50_A6C4F8 2-isopropylmalate synthase n=1 Tax=Planctomyces ... 254 5e-66 UniRef50_D2RXB9 Pyruvate carboxyltransferase n=3 Tax=Halobacteri... 250 1e-64 UniRef50_D2RVT7 Pyruvate carboxyltransferase n=1 Tax=Haloterrige... 249 2e-64 UniRef50_Q56216 2-isopropylmalate synthase (Fragment) n=1 Tax=Th... 248 4e-64 UniRef50_B9LUZ7 Pyruvate carboxyltransferase n=1 Tax=Halorubrum ... 248 5e-64 UniRef50_C9YAE2 Putative uncharacterized protein n=1 Tax=Curviba... 240 1e-61 UniRef50_Q57926 2-isopropylmalate synthase 1 n=16 Tax=Euryarchae... 239 2e-61 UniRef50_UPI000038E0F9 2-isopropylmalate synthase n=1 Tax=Ferrop... 234 8e-60 UniRef50_Q6L0K4 2-isopropylmalate synthase n=1 Tax=Picrophilus t... 231 3e-59 UniRef50_D2RHQ3 Isopropylmalate/citramalate/homocitratesynthase ... 230 1e-58 UniRef50_C4XS62 Pyruvate carboxyltransferase n=1 Tax=Desulfovibr... 229 1e-58 UniRef50_C9RKZ6 Pyruvate carboxyltransferase n=1 Tax=Fibrobacter... 229 2e-58 UniRef50_O66682 Uncharacterized AIPM/Hcit synthase family transf... 215 3e-54 UniRef50_P58967 2-isopropylmalate synthase 1 n=9 Tax=Euryarchaeo... 214 7e-54 UniRef50_B4B8D2 Pyruvate carboxyltransferase n=1 Tax=Cyanothece ... 212 3e-53 UniRef50_D2L197 Pyruvate carboxyltransferase n=1 Tax=Desulfovibr... 210 1e-52 UniRef50_A6FCI3 2-isopropylmalate synthase n=1 Tax=Moritella sp.... 207 6e-52 UniRef50_Q2FKU8 2-isopropylmalate synthase n=3 Tax=Methanomicrob... 204 6e-51 UniRef50_C3MPM7 2-isopropylmalate synthase n=19 Tax=Thermoprotei... 204 8e-51 UniRef50_C8WE03 Homocitrate synthase n=3 Tax=Zymomonas mobilis R... 200 1e-49 UniRef50_Q2RGA1 2-isopropylmalate synthase n=5 Tax=Clostridia Re... 196 2e-48 UniRef50_B1L4G2 Pyruvate carboxyltransferase n=1 Tax=Candidatus ... 195 3e-48 UniRef50_C5QA64 2-isopropylmalate synthase n=1 Tax=Staphylococcu... 192 3e-47 UniRef50_C7N750 Isopropylmalate/homocitrate/citramalate synthase... 192 4e-47 UniRef50_D1J0N9 Whole genome shotgun sequence of line PN40024, s... 191 4e-47 UniRef50_D1AJT6 2-isopropylmalate synthase/homocitrate synthase ... 190 9e-47 UniRef50_A6LPH9 Homocitrate synthase n=10 Tax=Clostridia RepID=A... 190 1e-46 UniRef50_A9HXK1 2-isopropylmalate synthase (Fragment) n=1 Tax=Ro... 189 3e-46 UniRef50_A0YSY8 2-isopropylmalate synthase n=1 Tax=Lyngbya sp. P... 183 1e-44 UniRef50_Q3A2Q7 Homocitrate synthase 1 n=18 Tax=Bacteria RepID=Q... 182 2e-44 UniRef50_Q2JTM1 Homocitrate synthase NifV n=7 Tax=Cyanobacteria ... 182 3e-44 UniRef50_Q6KZ01 2-isopropylmalate synthase n=1 Tax=Picrophilus t... 180 1e-43 UniRef50_A6TTX4 Pyruvate carboxyltransferase n=1 Tax=Alkaliphilu... 179 2e-43 UniRef50_B8FAB3 Pyruvate carboxyltransferase n=1 Tax=Desulfatiba... 179 3e-43 UniRef50_Q02CM5 2-isopropylmalate synthase n=1 Tax=Candidatus So... 178 4e-43 UniRef50_B3DXX9 Homocitrate/citramalate synthase n=1 Tax=Methyla... 177 7e-43 UniRef50_B4S9H2 Pyruvate carboxyltransferase n=13 Tax=Bacteria R... 177 9e-43 UniRef50_C6HVD7 2-isopropylmalate synthase n=1 Tax=Leptospirillu... 175 4e-42 UniRef50_C3NF24 2-isopropylmalate synthase/homocitrate synthase ... 174 9e-42 UniRef50_Q04QM8 Isopropylmalate/homocitrate/citramalatesynthase ... 174 9e-42 UniRef50_UPI000038E0D5 2-isopropylmalate synthase n=1 Tax=Ferrop... 173 1e-41 UniRef50_Q9V1J1 2-isopropylmalate synthase 2 n=5 Tax=Thermococca... 172 3e-41 UniRef50_Q44290 Homocitrate synthase 1 n=45 Tax=Bacteria RepID=N... 172 4e-41 UniRef50_A4A2P3 2-isopropylmalate synthase n=1 Tax=Blastopirellu... 171 4e-41 UniRef50_A8F3U8 2-isopropylmalate synthase n=1 Tax=Thermotoga le... 171 6e-41 UniRef50_A8ZTR1 2-isopropylmalate synthase/homocitrate synthase ... 171 6e-41 UniRef50_B9KY22 2-isopropylmalate synthase/homocitrate synthase ... 171 8e-41 UniRef50_B8I2I3 Pyruvate carboxyltransferase n=1 Tax=Clostridium... 170 1e-40 UniRef50_C1SID8 Isopropylmalate/homocitrate/citramalate synthase... 170 1e-40 UniRef50_B2UP78 2-isopropylmalate synthase/homocitrate synthase ... 169 2e-40 UniRef50_UPI0001B425AC 2-isopropylmalate synthase n=1 Tax=Lister... 169 2e-40 UniRef50_A7IBL6 Homocitrate synthase n=19 Tax=Proteobacteria Rep... 168 4e-40 UniRef50_D2LHQ1 Homocitrate synthase n=1 Tax=Rhodomicrobium vann... 168 5e-40 UniRef50_A5VPL4 2-isopropylmalate synthase/homocitrate synthase ... 167 7e-40 UniRef50_B0TW82 2-isopropylmalate synthase n=17 Tax=Francisella ... 167 1e-39 UniRef50_C6VV54 Pyruvate carboxyltransferase n=32 Tax=Bacteria R... 166 2e-39 UniRef50_C0AC93 Trans-homoaconitate synthase n=2 Tax=Opitutaceae... 163 1e-38 UniRef50_A9A1L0 Pyruvate carboxyltransferase n=6 Tax=Thaumarchae... 161 6e-38 UniRef50_C9RN88 2-isopropylmalate synthase/homocitrate synthase ... 160 8e-38 UniRef50_B5JMT2 HMGL-like domain protein n=1 Tax=Verrucomicrobia... 160 1e-37 UniRef50_B3TC58 Putative HMGL-like protein n=1 Tax=uncultured ma... 158 4e-37 UniRef50_Q3M862 2-isopropylmalate synthase n=4 Tax=Bacteria RepI... 158 4e-37 UniRef50_P74269 Uncharacterized AIPM/Hcit synthase family transf... 158 5e-37 UniRef50_D0LNR8 Pyruvate carboxyltransferase n=1 Tax=Haliangium ... 157 8e-37 UniRef50_D2QST1 Pyruvate carboxyltransferase n=1 Tax=Spirosoma l... 154 6e-36 UniRef50_P54610 Homocitrate synthase n=6 Tax=Frankia RepID=NIFV_... 153 2e-35 UniRef50_B6YRB4 Homocitrate synthase n=1 Tax=Candidatus Azobacte... 152 2e-35 UniRef50_Q0ZQ46 FrbC n=3 Tax=Bacteria RepID=Q0ZQ46_9ACTO 152 4e-35 UniRef50_B0TAQ1 Homocitrate synthase, nifv n=4 Tax=Clostridiales... 152 4e-35 UniRef50_Q0PQP5 2-isopropylmalate synthase (Fragment) n=2 Tax=En... 149 2e-34 UniRef50_Q2FZS6 2-isopropylmalate synthase, putative n=51 Tax=St... 149 2e-34 UniRef50_O86511 Uncharacterized AIPM/Hcit synthase family transf... 149 4e-34 UniRef50_A0LSS5 2-isopropylmalate synthase n=12 Tax=Bacteria Rep... 147 8e-34 UniRef50_Q3IV11 Isopropylmalate/homocitrate synthase n=1 Tax=Rho... 146 2e-33 UniRef50_A4MW39 2-isopropylmalate synthase n=3 Tax=Haemophilus i... 144 6e-33 UniRef50_Q01181 Homocitrate synthase n=27 Tax=Proteobacteria Rep... 144 7e-33 UniRef50_Q04TA5 2-isopropylmalate/homocitrate synthase n=14 Tax=... 144 1e-32 UniRef50_C6BX35 Pyruvate carboxyltransferase n=1 Tax=Desulfovibr... 144 1e-32 UniRef50_Q52070 Homocitrate synthase n=9 Tax=Gammaproteobacteria... 141 5e-32 UniRef50_A3JSY7 Putative uncharacterized protein n=2 Tax=Bacteri... 141 7e-32 UniRef50_A5KHS6 3-isopropylmalate dehydrogenase n=1 Tax=Campylob... 140 9e-32 UniRef50_B9YLN5 2-isopropylmalate synthase n=2 Tax=Nostocaceae R... 140 1e-31 UniRef50_C0W2B6 Alpha-isopropylmalate/homocitrate synthase famil... 139 2e-31 UniRef50_Q0EZI5 2-isopropylmalate synthase n=1 Tax=Mariprofundus... 139 3e-31 UniRef50_A6FZR1 Homocitrate synthase n=1 Tax=Plesiocystis pacifi... 139 3e-31 UniRef50_Q07179 Homocitrate synthase n=3 Tax=Rhodobacter RepID=N... 139 4e-31 UniRef50_P70728 Homocitrate synthase n=1 Tax=Azospirillum brasil... 137 1e-30 UniRef50_Q1DCT2 2-isopropylmalate synthase/homocitrate synthase ... 135 4e-30 UniRef50_Q12122 Homocitrate synthase, mitochondrial n=109 Tax=ce... 135 5e-30 UniRef50_C5AK37 Isopropylmalate/homocitrate/citramalate synthase... 134 1e-29 UniRef50_D1PA75 (R)-citramalate synthase n=1 Tax=Prevotella copr... 133 2e-29 UniRef50_Q97MC5 2-isopropylmalate synthase n=50 Tax=Bacteria Rep... 132 4e-29 UniRef50_Q10Y65 2-isopropylmalate synthase n=1 Tax=Trichodesmium... 132 4e-29 UniRef50_B7G5N8 2-isopropylmalate synthase n=2 Tax=Bacillariophy... 130 9e-29 UniRef50_C0Z7H0 Alpha-isopropylmalate/homocitrate synthase famil... 130 1e-28 UniRef50_C1XGU5 Isopropylmalate/homocitrate/citramalate synthase... 129 4e-28 UniRef50_A9VAW1 Predicted protein n=1 Tax=Monosiga brevicollis R... 128 4e-28 UniRef50_C7LNR6 Pyruvate carboxyltransferase n=1 Tax=Desulfomicr... 127 1e-27 UniRef50_A4QAP0 2-isopropylmalate synthase n=225 Tax=cellular or... 126 2e-27 UniRef50_Q0W3Q1 2-isopropylmalate synthase n=8 Tax=Archaea RepID... 126 2e-27 UniRef50_Q1IYY1 Homocitrate synthase n=1 Tax=Deinococcus geother... 126 2e-27 UniRef50_A6DIP7 2-isopropylmalate synthase n=1 Tax=Lentisphaera ... 126 2e-27 UniRef50_Q7M8U7 HOMOCITRATE SYTHASE 1 n=1 Tax=Wolinella succinog... 126 3e-27 UniRef50_C5S831 2-isopropylmalate synthase n=20 Tax=Bacteria Rep... 125 3e-27 UniRef50_C8WRC1 2-isopropylmalate synthase n=14 Tax=Bacteria Rep... 125 3e-27 UniRef50_B2KBD6 Pyruvate carboxyltransferase n=7 Tax=Bacteria Re... 125 4e-27 UniRef50_C6A4Y6 2-isopropylmalate synthase 1 n=1 Tax=Thermococcu... 125 5e-27 UniRef50_C8W3E1 Pyruvate carboxyltransferase n=1 Tax=Desulfotoma... 123 2e-26 UniRef50_Q12166 2-isopropylmalate synthase 2, mitochondrial n=8 ... 123 2e-26 UniRef50_B8FYI5 Pyruvate carboxyltransferase n=5 Tax=Bacteria Re... 122 3e-26 UniRef50_A8TLL5 Homocitrate synthase n=1 Tax=alpha proteobacteri... 122 3e-26 UniRef50_C0GSN3 Pyruvate carboxyltransferase n=1 Tax=Desulfonatr... 121 8e-26 UniRef50_P06208 2-isopropylmalate synthase n=109 Tax=cellular or... 120 1e-25 UniRef50_B3PEP5 2-isopropylmalate synthase n=90 Tax=Bacteria Rep... 119 2e-25 UniRef50_B8FRV4 2-isopropylmalate synthase n=2 Tax=Desulfitobact... 119 2e-25 UniRef50_A1KBD3 2-isopropylmalate synthase n=14 Tax=Bacteria Rep... 119 4e-25 UniRef50_Q7VH30 2-isopropylmalate synthase n=16 Tax=Bacteria Rep... 117 1e-24 UniRef50_Q7X1M2 Homocitrate synthase (Fragment) n=1 Tax=Leptospi... 117 1e-24 UniRef50_B1I1Z4 Pyruvate carboxyltransferase n=1 Tax=Candidatus ... 115 6e-24 UniRef50_A8L551 2-isopropylmalate synthase n=38 Tax=Bacteria Rep... 114 6e-24 UniRef50_C7IGD9 Homocitrate synthase n=1 Tax=Clostridium papyros... 114 9e-24 UniRef50_B2AHM5 2-isopropylmalate synthase n=69 Tax=cellular org... 112 4e-23 UniRef50_B0PEC7 Putative uncharacterized protein n=1 Tax=Anaerot... 112 5e-23 UniRef50_D1U2X4 Pyruvate carboxyltransferase n=1 Tax=Desulfovibr... 110 1e-22 UniRef50_Q00853 Homocitrate synthase subunit alpha n=8 Tax=Clost... 108 4e-22 UniRef50_D1WUS8 2-isopropylmalate synthase n=2 Tax=Streptomyces ... 108 4e-22 UniRef50_Q1NS12 Pyruvate carboxyltransferase n=2 Tax=delta prote... 108 4e-22 UniRef50_B1QUV5 Homocitrate synthase 1 n=2 Tax=Clostridium butyr... 108 4e-22 UniRef50_Q46A98 Homocitrate synthase n=2 Tax=Methanosarcina RepI... 107 1e-21 UniRef50_B0CSN8 Predicted protein (Fragment) n=11 Tax=cellular o... 107 1e-21 UniRef50_C9K7B8 Similar to 2-isopropylmalate synthase n=1 Tax=Al... 107 2e-21 UniRef50_D1N7Y9 Pyruvate carboxyltransferase n=2 Tax=Victivallis... 105 3e-21 UniRef50_B7GT76 2-isopropylmalate synthase n=19 Tax=Bifidobacter... 104 7e-21 UniRef50_C7YY11 Putative uncharacterized protein n=2 Tax=Nectria... 103 2e-20 UniRef50_B8J227 Pyruvate carboxyltransferase n=2 Tax=Desulfovibr... 102 5e-20 UniRef50_A2QSZ0 Contig An09c0020, complete genome n=1 Tax=Asperg... 101 6e-20 UniRef50_B8DR73 Pyruvate carboxyltransferase n=3 Tax=Desulfovibr... 100 1e-19 UniRef50_Q1QBL0 2-isopropylmalate synthase n=5 Tax=Bacteria RepI... 100 2e-19 UniRef50_C1FHL1 2-isopropylmalate synthase n=2 Tax=cellular orga... 99 3e-19 UniRef50_B1L5J0 2-isopropylmalate synthase n=1 Tax=Candidatus Ko... 98 7e-19 UniRef50_D2JWV4 Putative homocitrate synthase n=1 Tax=Filobasidi... 95 7e-18 UniRef50_D0LGL9 2-isopropylmalate synthase n=3 Tax=Nannocystinea... 95 8e-18 UniRef50_B2J8P8 Pyruvate carboxyltransferase n=2 Tax=Nostocaceae... 93 2e-17 UniRef50_C8QZK2 2-isopropylmalate synthase n=1 Tax=Desulfurivibr... 92 3e-17 UniRef50_A8MB07 2-isopropylmalate synthase n=1 Tax=Caldivirga ma... 92 4e-17 UniRef50_B4VB43 2-isopropylmalate synthase n=1 Tax=Streptomyces ... 92 4e-17 UniRef50_Q0PQP4 2-isopropylmalate synthase (Fragment) n=1 Tax=En... 91 8e-17 UniRef50_D2MHM3 2-isopropylmalate synthase (Fragment) n=1 Tax=Ca... 91 9e-17 UniRef50_C1MYB9 2-isopropylmalate synthase n=1 Tax=Micromonas pu... 91 1e-16 UniRef50_Q5KCL7 2-isopropylmalate synthase, putative n=1 Tax=Fil... 91 1e-16 UniRef50_Q72WS3 Homocitrate synthase n=2 Tax=Desulfovibrio vulga... 90 2e-16 UniRef50_B5HTY3 2-isopropylmalate synthase n=1 Tax=Streptomyces ... 89 4e-16 UniRef50_C7GH85 2-isopropylmalate synthase n=3 Tax=Roseburia Rep... 89 4e-16 UniRef50_A5N6T4 2-isopropylmalate synthase-related protein n=2 T... 89 5e-16 UniRef50_D1XS06 2-isopropylmalate synthase n=1 Tax=Streptomyces ... 88 7e-16 UniRef50_A8MBK1 Pyruvate carboxyltransferase n=1 Tax=Caldivirga ... 87 1e-15 UniRef50_Q2GMU3 Putative uncharacterized protein n=1 Tax=Chaetom... 86 2e-15 UniRef50_C1AUX2 2-isopropylmalate synthase n=8 Tax=Bacteria RepI... 86 3e-15 UniRef50_C8SJR8 Homocitrate synthase n=1 Tax=Mesorhizobium oppor... 85 6e-15 UniRef50_Q97A78 2-isopropylmalate/homocitrate synthetase n=1 Tax... 84 1e-14 UniRef50_A8A943 Pyruvate carboxyltransferase n=1 Tax=Ignicoccus ... 82 5e-14 UniRef50_Q05FR2 2-isopropylmalate synthase n=1 Tax=Candidatus Ca... 82 5e-14 UniRef50_B9K380 Isopropylmalate/homocitrate/citramalate synthase... 82 6e-14 UniRef50_A9A1R9 Pyruvate carboxyltransferase n=2 Tax=Archaea Rep... 82 7e-14 UniRef50_Q46A99 Homocitrate synthase n=2 Tax=Methanosarcina RepI... 81 1e-13 UniRef50_A9FUN7 Putative 2-isopropylmalate synthase n=1 Tax=Sora... 80 1e-13 UniRef50_A4J5K5 Isopropylmalate/homocitrate/citramalate synthase... 80 1e-13 UniRef50_B4WHZ2 HMGL-like domain protein n=1 Tax=Synechococcus s... 80 1e-13 UniRef50_B8H935 Pyruvate carboxyltransferase n=7 Tax=Actinomycet... 80 2e-13 UniRef50_B8G187 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Desulfi... 77 2e-12 UniRef50_A4QUQ8 Putative uncharacterized protein n=1 Tax=Magnapo... 77 2e-12 UniRef50_A7NPM1 Pyruvate carboxyltransferase n=2 Tax=Roseiflexus... 74 1e-11 UniRef50_Q2LTE1 Isopropylmalate/homocitrate/citramalate synthase... 74 2e-11 UniRef50_UPI000038E183 2-isopropylmalate synthase n=1 Tax=Ferrop... 73 2e-11 UniRef50_A5LD67 2-isopropylmalate synthase/homocitrate synthase ... 73 2e-11 UniRef50_C8WQC0 Pyruvate carboxyltransferase n=2 Tax=Alicyclobac... 72 4e-11 UniRef50_Q97MD8 Homocitrate syntase, omega subunit nifV (NivO) n... 72 7e-11 UniRef50_C0QM22 LeuA1 n=1 Tax=Desulfobacterium autotrophicum HRM... 72 7e-11 UniRef50_B1VRH5 4-hydroxy-2-oxovalerate aldolase n=14 Tax=cellul... 72 7e-11 UniRef50_C0GGI7 Pyruvate carboxyltransferase n=1 Tax=Dethiobacte... 71 9e-11 UniRef50_D2S7Y3 Pyruvate carboxyltransferase n=3 Tax=Actinomycet... 69 5e-10 UniRef50_A3P825 4-hydroxy-2-oxovalerate aldolase n=20 Tax=Burkho... 69 5e-10 UniRef50_B9LMV8 Pyruvate carboxyltransferase n=1 Tax=Halorubrum ... 69 5e-10 UniRef50_Q1IW44 HMGL-like domain protein n=4 Tax=Bacteria RepID=... 69 6e-10 UniRef50_C9P0G7 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Vibrio ... 67 1e-09 UniRef50_Q5WKL8 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillac... 67 1e-09 UniRef50_C5RN58 NifV2 n=1 Tax=Clostridium cellulovorans 743B Rep... 66 3e-09 UniRef50_A9F2G5 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacteria... 66 4e-09 UniRef50_D0Z8X0 Putative hydroxymethylglutaryl-CoA lyase n=1 Tax... 65 6e-09 UniRef50_D1PZE3 2-isopropylmalate synthase (Fragment) n=1 Tax=Pr... 65 6e-09 UniRef50_A3JC95 Pyruvate carboxyltransferase n=5 Tax=Gammaproteo... 65 8e-09 UniRef50_B1QUV6 Homocitrate synthase, omega subunit n=2 Tax=Clos... 64 1e-08 UniRef50_P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial n... 64 2e-08 >UniRef50_A6T4L9 2-isopropylmalate synthase n=327 Tax=Bacteria RepID=LEU1_KLEP7 Length = 523 Score = 1024 bits (2648), Expect = 0.0, Method: Compositional matrix adjust. Identities = 486/523 (92%), Positives = 512/523 (97%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT Sbjct: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 IAR +KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE Sbjct: 61 IARTIKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE+ Sbjct: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEY 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 A IISGLY+RVPNIDKAIISVHTHDDLG+AVGN+LAAVHAGARQVEGAMNGIGERAGNC+ Sbjct: 181 ANIISGLYDRVPNIDKAIISVHTHDDLGIAVGNALAAVHAGARQVEGAMNGIGERAGNCA 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEVIMAIKVRKDI+NVHT INH EIWRTSQ VSQICNMPIPANKAIVG+GAFAHSSGIH Sbjct: 241 LEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGTGAFAHSSGIH 300 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 QDGVLKNRENYEIMTPESIGLNQ+QLNLTSRSGRAAVKHRM+EMGY+ES+YNLD+LYDAF Sbjct: 301 QDGVLKNRENYEIMTPESIGLNQVQLNLTSRSGRAAVKHRMEEMGYQESDYNLDHLYDAF 360 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 LKLADKKGQVFDYDLEALAFI KQQEEPEHFRLDYF+VQSGS+DIATA++KL CG+E+K Sbjct: 361 LKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFNVQSGSSDIATASIKLVCGDEIKT 420 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 EAANGNGPVDA+YQAINR+T+YN+ELVKY L+AKGHGKDALGQVDIV +YNGRRFHGVGL Sbjct: 421 EAANGNGPVDAIYQAINRVTDYNIELVKYGLSAKGHGKDALGQVDIVVDYNGRRFHGVGL 480 Query: 481 ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV 523 ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQ+ ENNKETV Sbjct: 481 ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV 523 >UniRef50_B2VDA7 2-isopropylmalate synthase n=4 Tax=Enterobacteriaceae RepID=LEU1_ERWT9 Length = 522 Score = 907 bits (2345), Expect = 0.0, Method: Compositional matrix adjust. Identities = 431/523 (82%), Positives = 477/523 (91%), Gaps = 1/523 (0%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT Sbjct: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 IARQ+KNSRVC LARCVEKDID A E+L+VA+A+RIHTF+ATSPMHIATKLRSTL EVIE Sbjct: 61 IARQIKNSRVCGLARCVEKDIDAAYEALRVADAYRIHTFLATSPMHIATKLRSTLPEVIE 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 RA+ M++RARNYTDDVEFSCED GRTPI DL RVVEAAINAGATTINIPDTVGYT+P+E+ Sbjct: 121 RAVKMIRRARNYTDDVEFSCEDGGRTPIDDLCRVVEAAINAGATTINIPDTVGYTLPYEY 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 A I S L RVPNIDKAI+SVHTHDDLG+AVGN+LAAV+AGARQ+EGAMNG+GERAGNC+ Sbjct: 181 ANIFSALRARVPNIDKAILSVHTHDDLGMAVGNALAAVNAGARQIEGAMNGLGERAGNCA 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEE IMAIK R ++NVHT INHQEI+RT Q VS+ICNMPIPA+KAI+GS AFAHSSGIH Sbjct: 241 LEETIMAIKTRGQLMNVHTRINHQEIYRTCQTVSKICNMPIPAHKAIIGSNAFAHSSGIH 300 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 QDGVLKNRENYEI+TPESIGL Q+QLNLTSRSGRAAVKHRM+EMGY E+EYN+D LYDAF Sbjct: 301 QDGVLKNRENYEILTPESIGLKQVQLNLTSRSGRAAVKHRMEEMGYGETEYNMDRLYDAF 360 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 LADKKGQVFDYDLEALAFI +Q EEPE+FRLD F+VQSGS+ IATA V+L CG+E K Sbjct: 361 KALADKKGQVFDYDLEALAFINQQSEEPEYFRLDTFNVQSGSSVIATATVQLRCGDEQKT 420 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 EAA GNGPVDAVYQAINR+TE++ ELV Y LTAKGHGKDALGQVDIV YNGR+FHGVGL Sbjct: 421 EAATGNGPVDAVYQAINRLTEFDAELVSYQLTAKGHGKDALGQVDIVVQYNGRKFHGVGL 480 Query: 481 ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV 523 ATDIVESSAKAMV+ LN IWRA +VE+ELQRK+Q ++ KETV Sbjct: 481 ATDIVESSAKAMVNALNTIWRARQVEQELQRKSQ-VKDQKETV 522 >UniRef50_P48571 2-isopropylmalate synthase n=3 Tax=Buchnera aphidicola RepID=LEU1_BUCRP Length = 518 Score = 756 bits (1953), Expect = 0.0, Method: Compositional matrix adjust. Identities = 350/506 (69%), Positives = 430/506 (84%), Gaps = 1/506 (0%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+ QVIIFDTTLRDGEQALQASLSVK+KLQIAL+LE G+D++EVGFP+SSPGDF+SVQT Sbjct: 1 MNSQVIIFDTTLRDGEQALQASLSVKQKLQIALSLENTGIDIIEVGFPISSPGDFKSVQT 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I++ +KNSR+C+LARC++KDID AAE++ + AFRIH F+ATS +H+ +KL+ D++I+ Sbjct: 61 ISKNIKNSRICSLARCLDKDIDAAAEAMHSSNAFRIHIFLATSILHMESKLKKNFDQIID 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 AI VKRA YTDDVEFSCEDA RT + +L R+VE INAG TINIPDTVGYT+P E Sbjct: 121 MAITSVKRALRYTDDVEFSCEDASRTTMDNLCRIVEKLINAGVKTINIPDTVGYTVPNEL 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 + II L++RVPNIDK+IISVH H+DLG+AVGNS++A+ AGARQ+EG +NGIGERAGN + Sbjct: 181 SSIIHNLFQRVPNIDKSIISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTA 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEVI+AIKVR+D+L V T I H+EI+RTSQ++SQICN+PIP NKAIVGS AFAHSSGIH Sbjct: 241 LEEVIIAIKVREDVLGVSTKIKHKEIYRTSQIISQICNLPIPPNKAIVGSNAFAHSSGIH 300 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 QDGVLKNR+NYEIM P SIGL +++LNLTSRSGRAAVKH M EMGY+E +Y +D LY +F Sbjct: 301 QDGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKHYMTEMGYRECDYKIDELYASF 360 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 LKLADKKGQVFDYDLEALAFI +QQEE EHF L +FSVQS SN ++TA+VKL CG++ Sbjct: 361 LKLADKKGQVFDYDLEALAFINQQQEELEHFSLSFFSVQSISNGLSTASVKLLCGKKTFI 420 Query: 421 EAA-NGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVG 479 E+A NGP+DA+YQA+NRIT + + L KY L AKG GKDALGQVDI+ + R+FHG+G Sbjct: 421 ESATTSNGPIDAIYQALNRITHFPIILQKYQLIAKGKGKDALGQVDILVEHKKRKFHGMG 480 Query: 480 LATDIVESSAKAMVHVLNNIWRAAEV 505 LATDI+ESSA+AMV+VLNNIW+A +V Sbjct: 481 LATDIIESSAQAMVNVLNNIWKANQV 506 >UniRef50_Q3AEQ5 2-isopropylmalate synthase n=42 Tax=Bacteria RepID=LEU1_CARHZ Length = 509 Score = 511 bits (1316), Expect = e-143, Method: Compositional matrix adjust. Identities = 268/503 (53%), Positives = 352/503 (69%), Gaps = 10/503 (1%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 ++V IFDTTLRDGEQ+ SL+ EKLQIA L+++GVDV+E GFP++SPGD E+V IA Sbjct: 2 ERVRIFDTTLRDGEQSPGVSLNAMEKLQIARQLQKLGVDVIEAGFPITSPGDKEAVSLIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 R+VK V ALAR DI+ A +++K AE+ RIHTFIATS +H+ KL+ + V+ERA Sbjct: 62 REVKGVVVAALARASALDIETAWDAIKDAESPRIHTFIATSDIHLKYKLKMDRETVVERA 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + VK A+ +T DVEFS EDA R+ + L RVVEAA+ AGATTINIPDTVGY P EF Sbjct: 122 VAAVKLAKKFTADVEFSAEDASRSDLDFLCRVVEAAVKAGATTINIPDTVGYAEPEEFGE 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I + E+VP +D+A++SVH HDDLGLAV NSLAA+ GARQVE +NGIGERAGNCSLE Sbjct: 182 FICKILEKVPVMDRAVLSVHCHDDLGLAVANSLAAIKNGARQVECTINGIGERAGNCSLE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E++MA+ RKD+L +T I +EI+RTS+LVS + MP+ NKAIVG AF+H SGIHQD Sbjct: 242 EIVMALYTRKDVLPFYTGIKTEEIYRTSKLVSNLTGMPVQPNKAIVGKNAFSHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 GVLK R YEIM P +G+ + +L L SGR A+K R+ E+GY+ +E L+ + F Sbjct: 302 GVLKERTTYEIMNPRLVGIPESRLVLGKHSGRHALKERLLELGYELTEEQLNEAFVKFKA 361 Query: 363 LADKKGQVFDYDLEALAFIGKQQEE----PEHFRLDYFSVQSGSNDIATAAVKLACGEEV 418 LADKK +V D DLEA+ +EE PE + LDYF + +GS I TA V L E Sbjct: 362 LADKKKEVTDQDLEAM-----MEEEIRKVPETYTLDYFHISTGSTIIPTATVGLIKEGEK 416 Query: 419 KAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDI-VANYNGRRFHG 477 +AA G+GPVDA+Y+AIN+IT L +YS+ A G+DALG+V + + N G+ G Sbjct: 417 LEDAATGDGPVDAIYKAINKITGLTPVLEQYSINAVTSGEDALGEVVVKLKNGLGKIVTG 476 Query: 478 VGLATDIVESSAKAMVHVLNNIW 500 G++TDI+E+SAKA ++ +N + Sbjct: 477 RGVSTDILEASAKAYLNGINKLL 499 >UniRef50_B6YRN0 2-isopropylmalate synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YRN0_AZOPC Length = 504 Score = 477 bits (1228), Expect = e-133, Method: Compositional matrix adjust. Identities = 243/493 (49%), Positives = 331/493 (67%), Gaps = 3/493 (0%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V IFDTTLRDGEQ L+ EK+Q+A +LE +GVD++E GFP+SSPGDF SV I++ Sbjct: 11 VFIFDTTLRDGEQVPGCQLNTIEKIQVAQSLESLGVDIIEAGFPISSPGDFNSVIEISKS 70 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 V + +CAL R +EKDID+AAESL+ A+ RIHT I TSP HI K ST DE++ERA+ Sbjct: 71 VTWTIICALTRAIEKDIDIAAESLQYAKRKRIHTGIGTSPYHIKYKFNSTQDEILERAVA 130 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 VK A+ Y +D+EF CEDAGRT LAR+VEA I AGA +NIPDT GY +P E+ I Sbjct: 131 SVKYAKKYVEDIEFYCEDAGRTDNVYLARIVEAVIKAGAKVVNIPDTTGYCLPEEYGAKI 190 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 L + V I I+S H H+DLG+A N+++ + GARQVE +NGIGERAGN SLEEV Sbjct: 191 KFLMDNVKGIQNVILSTHCHNDLGMATANTISGIINGARQVEVTINGIGERAGNTSLEEV 250 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 +M IK K+ LN+ T IN + I+ S+++S + NMP+ NKAIVG AFAHSSGIHQDG+ Sbjct: 251 VMIIKSHKE-LNIGTNINTKHIYPISRMISSLMNMPVQPNKAIVGRNAFAHSSGIHQDGI 309 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 LKNRENYEI+ P+ IG++ + LT+RSGRAA+K+R++ +G + S+ LD++Y+ FLKLA Sbjct: 310 LKNRENYEIIDPKDIGIDNNIIALTARSGRAALKYRLNILGIELSQKKLDDIYEEFLKLA 369 Query: 365 DKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAAN 424 D K + D D+ LA GK + E RL+Y V SG + A++ L E AA+ Sbjct: 370 DYKKNINDDDILMLA--GKDRTESNRIRLEYLQVTSGVGILPVASICLNIAGEKFEAAAS 427 Query: 425 GNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDI 484 GNGPVDA +A+ +I + + ++ + A G + +G+V + YN ++G TDI Sbjct: 428 GNGPVDAAIRAVKQIIHRQMVIQEFLIQAINKGSNDVGKVHMQVKYNDVNYYGFAANTDI 487 Query: 485 VESSAKAMVHVLN 497 V +S +A + +N Sbjct: 488 VAASVEAFIDAIN 500 >UniRef50_Q7UI51 2-isopropylmalate synthase n=1 Tax=Rhodopirellula baltica RepID=LEU1_RHOBA Length = 527 Score = 475 bits (1223), Expect = e-132, Method: Compositional matrix adjust. Identities = 247/504 (49%), Positives = 339/504 (67%), Gaps = 11/504 (2%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 ++Q+ IFDTTLRDGEQ+ AS+++ EKL++A AL +GVD++E GFP++SPGDFESV+ I Sbjct: 15 TRQIRIFDTTLRDGEQSPGASMNLAEKLEVASALVDLGVDIIEAGFPIASPGDFESVRQI 74 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 A ++ + +C LARC EKDID A E+LK A RIH F+ATS +H KLR T DE++ER Sbjct: 75 ATTIRGATICGLARCAEKDIDRAWEALKTAPQARIHVFLATSAIHREFKLRMTPDEIVER 134 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 A+ V+RA ++ DDVEFS EDA RT L RVVEAAI+AGATTIN+PDTVGYT P E Sbjct: 135 AVAGVRRAASHCDDVEFSPEDACRTEHDFLCRVVEAAIDAGATTINVPDTVGYTTPGEIY 194 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 L +RVPN+DKA++S H HDDLG+AV NSLAAV AGA Q+E +NGIGERAGN +L Sbjct: 195 DRFKMLRDRVPNMDKAVLSTHCHDDLGMAVANSLAAVDAGAGQIECTINGIGERAGNAAL 254 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EE++MA+K R+D + T IN + + S+LVS+ + + NKAIVG AFAH SGIHQ Sbjct: 255 EELVMAMKTRQDFYHCQTNINSKRLVPVSRLVSKTTGINVQRNKAIVGRNAFAHESGIHQ 314 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 DG+LK R YEIM+PE +G + L L SGRAA+ R ++G + L +++AF Sbjct: 315 DGMLKERTTYEIMSPEEVGFTKTDLVLGKHSGRAALADRAKQLGMTLTGEQLQEVFEAFK 374 Query: 362 KLADKKGQVFDYDLEALAFIGKQQE-----EPEHFRLDYFSVQSGSNDIATAAVKLACGE 416 +LADKK +++D D+ AL QQ+ PE +DY V SG N V L E Sbjct: 375 ELADKKKEIYDGDIVALV----QQKISETVAPEWTLVDY-EVTSGKNQTPNVRVTLRRDE 429 Query: 417 E-VKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRF 475 + + + A G+GP+DA + A+ +IT V + + + G+DA+G+V++ + G+ + Sbjct: 430 QDITEQVAQGDGPIDAAFWAVEKITGIQVVCKDFRVRSATLGRDAIGEVNLEVEHEGKTY 489 Query: 476 HGVGLATDIVESSAKAMVHVLNNI 499 G G++TD VES+ AM++ +N I Sbjct: 490 RGTGVSTDSVESTILAMLNAINRI 513 >UniRef50_B8DM91 2-isopropylmalate synthase n=31 Tax=Bacteria RepID=LEU1_DESVM Length = 514 Score = 474 bits (1220), Expect = e-132, Method: Compositional matrix adjust. Identities = 252/499 (50%), Positives = 332/499 (66%), Gaps = 2/499 (0%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 S ++ IFDTTLRDGEQ+ A+++++EK+++A LE +GVD+ME GFP SS GDFE+VQ I Sbjct: 5 SGRIRIFDTTLRDGEQSPGATMNLQEKIRLARQLETLGVDIMEAGFPASSQGDFEAVQAI 64 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 AR VK V L R + DID A E++KVAE RIHTF+ATSP+H+ KLR D+V+E Sbjct: 65 ARAVKGVEVAGLCRAMPADIDRAWEAVKVAENPRIHTFLATSPVHMQYKLRKEPDQVVEM 124 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 A+ V+ A YT +VEFS EDA R+ L RV EA INAGATTIN+PDTVGY P EF Sbjct: 125 AVAAVRHAAKYTSNVEFSAEDASRSNPDFLVRVFEAVINAGATTINVPDTVGYAQPEEFG 184 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 +I + E PN KA+ SVH H+DLG+ V N+LAA+ AGARQ E ++GIGERAGN SL Sbjct: 185 RLIRYVIENTPNSHKAVFSVHCHNDLGMGVANTLAALKAGARQAEVTISGIGERAGNASL 244 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EE++MA+ R+D + + ++++ T +L+S I PIP NKAIVG+ AFAH SGIHQ Sbjct: 245 EEIVMALHTRRDFYQLDCGVVTEQLFPTCRLLSMIIGQPIPPNKAIVGANAFAHESGIHQ 304 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 DG+LKNRE YEIMTPESIG + L + SGR AVK+++DE+GY+ E L +++A Sbjct: 305 DGMLKNRETYEIMTPESIGKTKTDLVIGKHSGRNAVKNKLDELGYRLEEAQLVTVFEAVK 364 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDI-ATAAVKLACGEEVKA 420 KLADKK Q++D D+EAL + + P+ +RL SVQ + TAAV + EVK Sbjct: 365 KLADKKKQIYDEDIEAL-VLEEVYRLPDLYRLVNLSVQCSDTGMPPTAAVVMDVMGEVKR 423 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 A G GP+DAV+ I I L +YS+TA G DA G+V + NG G G Sbjct: 424 AAGFGVGPIDAVFNVIGEIVGRAPVLERYSVTAITGGTDAQGEVTVRLRQNGSSAVGRGS 483 Query: 481 ATDIVESSAKAMVHVLNNI 499 DI+ +SA+A V+ LN + Sbjct: 484 DPDIILASARAYVNALNRL 502 >UniRef50_Q2YBW0 2-isopropylmalate synthase n=2 Tax=Bacteria RepID=LEU1_NITMU Length = 510 Score = 470 bits (1209), Expect = e-131, Method: Compositional matrix adjust. Identities = 259/501 (51%), Positives = 339/501 (67%), Gaps = 4/501 (0%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M +IIFDTTLRDGEQ+ AS++ +EK++IA LERM VDV+E GFP +S GDFE+V+ Sbjct: 1 MKDHLIIFDTTLRDGEQSPGASMTREEKVRIARQLERMRVDVIEAGFPAASNGDFEAVKA 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 +A +K S +C LAR +E DI A E+L+ A + RIHTFIATSP+H+ KLR + D+V+E Sbjct: 61 VAAAIKGSTICGLARAIEGDIRRAGEALRGANSARIHTFIATSPIHMEKKLRMSPDQVVE 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 +A+ VK AR YTDDVEFS EDAGR+ I L RV+EA I+AGA T+NIPDTVGYTMP +F Sbjct: 121 QAVKAVKFARQYTDDVEFSPEDAGRSDITFLCRVLEAVIDAGAGTVNIPDTVGYTMPQQF 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 +I L ER+PN DK I SVH H+DLGLAV NSL+AV GARQVE +NG+GERAGN S Sbjct: 181 GELIRTLRERIPNSDKVIFSVHCHNDLGLAVANSLSAVMNGARQVECTVNGLGERAGNAS 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV+MA++ R+D T I+ I S+LVS I P+ NKAIVG+ AFAH SGIH Sbjct: 241 LEEVVMAVRTRQDFFPCDTRIDSVHIVPASKLVSGITGFPVQPNKAIVGANAFAHESGIH 300 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK-ESEYNLDNLYDA 359 QDGVLK+RE YEIM E +G +L L SGR A + R+ E+G + ESE L+ + Sbjct: 301 QDGVLKHRETYEIMRAEDVGWGANKLLLGKHSGRNAFRSRLAELGIELESEETLNATFMR 360 Query: 360 FLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLA-CGEEV 418 F +LADKK +FD DL AL + EH++L + S + + A++ + G E Sbjct: 361 FKELADKKHDIFDEDLHALVSDDAAALQ-EHYKLLSLTAHSETGETPHASIVIGEEGRES 419 Query: 419 KAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGV 478 +AE ++G+GPVDA ++AI +I VEL YS+ A G D+ G+V + +GR +G Sbjct: 420 RAE-SDGSGPVDATFRAIEKILNSGVELQLYSVNAITSGTDSQGEVTVRLQKSGRIVNGN 478 Query: 479 GLATDIVESSAKAMVHVLNNI 499 G TDIV +SAKA + LN + Sbjct: 479 GADTDIVVASAKAYLSALNKL 499 >UniRef50_A6LDN1 2-isopropylmalate synthase n=6 Tax=Bacteria RepID=A6LDN1_PARD8 Length = 500 Score = 466 bits (1199), Expect = e-130, Method: Compositional matrix adjust. Identities = 247/498 (49%), Positives = 327/498 (65%), Gaps = 4/498 (0%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 MS ++ IFDTTLRDGEQ L+ EK+Q+A ALE++GVDV+E GFPVSSPGDF+SV Sbjct: 1 MSDRLFIFDTTLRDGEQVPGCQLNTVEKIQVAKALEQLGVDVIEAGFPVSSPGDFKSVVE 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I++ V +CAL R VEKDIDVAAE+L+ A+ RIHT I TS HI K ST +E+IE Sbjct: 61 ISKAVTWPTICALTRAVEKDIDVAAEALRFAKRGRIHTGIGTSDSHIKYKFNSTREEIIE 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 RAI K A+ Y +DVEF CEDAGRT LARVVEA I AGAT +NIPDT GY +P E+ Sbjct: 121 RAIAATKYAKKYVEDVEFYCEDAGRTDNEYLARVVEAVIKAGATVVNIPDTTGYCLPDEY 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 I L E V + AI+S H H+DLG+A N++ V GARQVE +NGIGERAGN S Sbjct: 181 GAKIKYLMEHVDGVHNAILSTHCHNDLGMATANTVQGVLNGARQVEVTINGIGERAGNTS 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV M K K+ ++ T I +I+ TS++VS + NMP+ NKAIVG AFAHSSGIH Sbjct: 241 LEEVAMVFKSHKE-RDIITNITTNKIYSTSRMVSSLMNMPVQPNKAIVGRNAFAHSSGIH 299 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 QDGVLKN + YEI+ P+ +G++ + LT+RSGRAA+KHR+ +G + LD +YD F Sbjct: 300 QDGVLKNAQTYEIIDPKDVGIDDNAIVLTARSGRAALKHRLHVLGVDLEQEKLDKVYDEF 359 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 LKLAD+K + D D+ L +GK + +L+Y V SG + A++ L + Sbjct: 360 LKLADRKKDINDDDV--LMLVGKDRTATHRIKLEYLQVTSGVGVQSVASICLNLSGVRRY 417 Query: 421 EAANGNGPVDAVYQAINR-ITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVG 479 EAA GNGPVDA +A+ + I+ ++ + ++ + A G D G+V + YNG ++G Sbjct: 418 EAAAGNGPVDAGIKAVKKAISNSDMTIQEFLIQAINKGSDDTGKVHMQVEYNGATYYGFS 477 Query: 480 LATDIVESSAKAMVHVLN 497 TDI+ +S +A V +N Sbjct: 478 ANTDIIAASVEAFVDAIN 495 >UniRef50_B3DX88 2-isopropylmalate synthase n=12 Tax=Bacteria RepID=LEU1_METI4 Length = 506 Score = 459 bits (1180), Expect = e-127, Method: Compositional matrix adjust. Identities = 242/500 (48%), Positives = 343/500 (68%), Gaps = 4/500 (0%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 + ++I+FDTTLRDGEQ AS++ ++KL++A L R+GVDV+E GFPV S GDFESV I Sbjct: 5 ANRLIVFDTTLRDGEQCPGASMTSRQKLEVAKQLARLGVDVIEAGFPVISQGDFESVSEI 64 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAF-RIHTFIATSPMHIATKLRSTLDEVIE 120 A QVK ++C LARC+ KDI+ AAE+LK A RIH F+ATS +H KL +E++ Sbjct: 65 AAQVKGPKICGLARCLPKDIEAAAEALKAAADAARIHVFLATSQIHRRFKLAKDEEEIVR 124 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 A+ V+ A+ Y DVEFS EDA RT LA++++ I AGATT+NIPDTVGY +P EF Sbjct: 125 IAVEGVRLAKRYVQDVEFSAEDASRTEPEFLAKIIQKVIEAGATTVNIPDTVGYAVPEEF 184 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 A +I L++ V +IDK ++SVH H+DLGLAV NSLAA+ AGARQVEG +NGIGERAGN + Sbjct: 185 ASLIRYLFDHVQDIDKVVVSVHCHNDLGLAVSNSLAAIKAGARQVEGTINGIGERAGNAA 244 Query: 241 LEEVIMAIKVRKDIL-NVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 LEE+IMA+ R D + T I +EI RTS+LVS++ + + NKA+VG AFAH++GI Sbjct: 245 LEEIIMALHTRPDAFGKIETGIQLKEILRTSRLVSRMSGLAVQRNKAVVGENAFAHAAGI 304 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 HQDG+LK RE YEI+ P+ IG Q +L LT SGRAA+++R+ +G++ + +DN++ Sbjct: 305 HQDGILKKRETYEIIDPKIIGWEQSELPLTKHSGRAALENRLKILGFELEKEEIDNIFSQ 364 Query: 360 FLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVK 419 F ++ DKK ++D DL +L G+ E + L+Y +V S I A +KL GEEV Sbjct: 365 FKQIGDKKKFIYDDDLVSLVE-GQISRIKETYELEYVAVTVCSGGIPMATIKLRHGEEVL 423 Query: 420 AEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVG 479 +A+ G+G VDA +A++RIT + LV+Y + + GKDA+G+V + N++ ++ Sbjct: 424 VDASTGDGAVDAAMKAVDRITGQHGHLVEYEVKSVTEGKDAIGEVTVKVNFDSKKLVTAK 483 Query: 480 LA-TDIVESSAKAMVHVLNN 498 A TD++E+S KA ++ +N Sbjct: 484 AASTDVIEASIKAYLNAVNK 503 >UniRef50_B8J824 2-isopropylmalate synthase n=7 Tax=Bacteria RepID=B8J824_ANAD2 Length = 523 Score = 455 bits (1171), Expect = e-126, Method: Compositional matrix adjust. Identities = 241/500 (48%), Positives = 332/500 (66%), Gaps = 4/500 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 Q+V IFDTTLRDGEQ+ AS+++ +KLQ+A AL +GVDV+E GF +SPGD E++Q + Sbjct: 6 QRVTIFDTTLRDGEQSPGASMNLGQKLQVARALRDLGVDVIEAGFAAASPGDLEAIQAVG 65 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 RQV+ V +L+RC + DI+ + ++L A R H F+ATSP+H KL+ DE+I+R+ Sbjct: 66 RQVEGPIVASLSRCNKGDIEASWKALADAPRRRCHVFLATSPIHRDFKLKLAKDEIIKRS 125 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + VK AR DDVEFS ED+ RT + LA VVE I AG T+NIPDTVGY +P +A Sbjct: 126 VDGVKLAREKFDDVEFSAEDSARTELEFLAEVVERVIEAGVGTVNIPDTVGYALPSTYAE 185 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I L + V I+KA+ISVH H+DLG+AV NSLA V GARQVE +NGIGERAGN SLE Sbjct: 186 TIRYLRKHVRGIEKAVISVHCHNDLGMAVANSLAGVLEGARQVECTINGIGERAGNASLE 245 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E++MA K R D+L V T + + ++ TS+LVSQ+ + + NKAIVG AFAH +GIHQ Sbjct: 246 EIVMAFKTRHDVLGVTTGVQTERLFPTSRLVSQVTGLHVQRNKAIVGQNAFAHEAGIHQH 305 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G+L NRE YEIM PE +G + QL L SGR A+K R+ +GY+ E +D ++ F Sbjct: 306 GMLTNRETYEIMRPEEVGFARSQLVLGKHSGRHALKDRLLALGYQLDEAQIDKVFADFKV 365 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPE-HFRLDYFSVQSGSNDIATAAVKL--ACGEEVK 419 LADKK ++D D+EAL G+ + + L+ S SG+ + A+V L A GE ++ Sbjct: 366 LADKKKDIYDADIEALVVHGQILGKGSVAWELEALSTTSGTGTLPCASVALRSAAGERIQ 425 Query: 420 AEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVG 479 EAA G+GPVDAVY+AI ++T +++L Y + + G+DA G+V I + + G Sbjct: 426 -EAAAGDGPVDAVYRAIEKVTGISLKLRDYQIASVSRGEDAQGEVSIEVEHPTGVYRGRA 484 Query: 480 LATDIVESSAKAMVHVLNNI 499 L+TDI+E SA+A + V+N I Sbjct: 485 LSTDIIEGSARAFLDVVNRI 504 >UniRef50_B8J4F8 2-isopropylmalate synthase n=3 Tax=Desulfovibrionales RepID=B8J4F8_DESDA Length = 515 Score = 451 bits (1160), Expect = e-125, Method: Compositional matrix adjust. Identities = 248/522 (47%), Positives = 331/522 (63%), Gaps = 13/522 (2%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+ +V FDTTLRDGEQ+ A+++++EKL++A LE +GVD+ME GFP SSPGDFESVQ Sbjct: 1 MNNRVYFFDTTLRDGEQSPGATMNLQEKLRLAHQLEVLGVDIMEAGFPASSPGDFESVQR 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 IA Q + +V LARCV DID E++K A RIH F++TSP+H+ KLR D+V+ Sbjct: 61 IAAQAGDIQVAGLARCVAGDIDRCWEAIKNARNPRIHIFLSTSPLHMRHKLRKDPDDVLR 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 A+ VKR YTD+VEFSCED R+ L RVVEA I AGATT+N+PDTVGY P E+ Sbjct: 121 MAVEGVKRCAMYTDNVEFSCEDFSRSEPEFLCRVVEAVIKAGATTVNLPDTVGYAQPAEY 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 A I + PN DKA+ SVH H+DLGLAV N+LAA G RQ E +NGIGERAGN S Sbjct: 181 AARIEHVISNTPNSDKAVFSVHCHNDLGLAVANTLAAFRVGVRQAEVTLNGIGERAGNAS 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV+M ++VR+D + I ++++ + +L+S PIP NKAIVG+ AFAH SGIH Sbjct: 241 LEEVVMNLRVRQDYFGLEHNIVTEQLYPSCRLLSMTIGQPIPNNKAIVGANAFAHESGIH 300 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 QDG+LKNRE YEIMTP+S+G + L + SGR AV+++ + MGYK + L+ +++A Sbjct: 301 QDGMLKNRETYEIMTPQSVGRTESNLVIGKHSGRNAVRNKFEAMGYKLDDDQLNLIFEAV 360 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEE----PEHFRLDYFSVQSGSND--IATAAVKLAC 414 +LAD+K + D DL AL QEE P+ FRL + SVQS TAAV + Sbjct: 361 KQLADRKKNLHDDDLMALV-----QEEIYRAPDRFRLRHVSVQSSDTGGVPPTAAVIMDV 415 Query: 415 GEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRR 474 + + A G GPVDA++ I + EL +Y++ A G DALG+V + Sbjct: 416 DGKESSGAGFGVGPVDALFNVIADMVGREAELEQYAINAITGGTDALGEVTVRLRDGEYS 475 Query: 475 FHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHN 516 G G DI +SA+A V+ LN++ + E L QH+ Sbjct: 476 AVGRGTHPDIFVASARAYVNALNHLAKKEEEGPRLH--CQHD 515 >UniRef50_Q2IUT4 2-isopropylmalate synthase n=119 Tax=Bacteria RepID=LEU1_RHOP2 Length = 524 Score = 447 bits (1150), Expect = e-124, Method: Compositional matrix adjust. Identities = 234/500 (46%), Positives = 324/500 (64%), Gaps = 9/500 (1%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 +VIIFDTTLRDGEQ A+++ +EKL +A L+ MGVDV+E G+P +S GDFE+V IA+ Sbjct: 11 RVIIFDTTLRDGEQCPGATMTFEEKLNVARMLDDMGVDVIEAGYPFASDGDFEAVHEIAK 70 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 + KNS +C L+R KDID AE++K AE RIHTF++TSP+H+ KL+ +V E I Sbjct: 71 RSKNSVICGLSRASHKDIDRCAEAIKPAERGRIHTFLSTSPVHMKYKLQMEAAQVYEMVI 130 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 V RARN+TDDVE+S EDA RT L R +EAAI AGATTIN+PDTVGY +P E+ + Sbjct: 131 SSVTRARNHTDDVEWSAEDATRTEFDFLCRCIEAAIKAGATTINLPDTVGYAVPEEYREM 190 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 + E VPN DKA SVH H+DLG+AV NS+A V GARQ+E +NGIGERAGN +LEE Sbjct: 191 FRKVRETVPNSDKARFSVHCHNDLGMAVANSMAGVAGGARQIECTINGIGERAGNAALEE 250 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 ++MA++VR+D L I + S+ VS + P+ NKAIVG AFAH SGIHQDG Sbjct: 251 LVMAMRVRQDKLPYWNNIETTMLTHASKTVSAATSFPVQYNKAIVGRNAFAHESGIHQDG 310 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 ++KN + YEIMTPE++G+ L + SGRA + H+++E+GYK S +++++ F L Sbjct: 311 MIKNAQTYEIMTPETVGVKGTSLVMGKHSGRAGLIHKLEELGYKLSRNQIEDVFVRFKAL 370 Query: 364 ADKKGQVFDYDLEALA----FIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVK 419 AD+K V+D D+EAL G+ Q +L+ +V +G++ A +KL +++ Sbjct: 371 ADRKKDVYDEDIEALVDEQLLHGQDQ-----IKLNSLTVIAGTHGPQRATMKLDVDGQIR 425 Query: 420 AEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVG 479 E A GNGPVDAV+ I + ++ +L Y + A G DA +V + ++ GR Sbjct: 426 IEEAEGNGPVDAVFNCIKALVPHDAKLELYQVHAVTEGTDAQAEVSVRLSHEGRSMTARA 485 Query: 480 LATDIVESSAKAMVHVLNNI 499 D + +SAKA + LN I Sbjct: 486 ADPDTLVASAKAYLGALNKI 505 >UniRef50_A6EER4 2-isopropylmalate synthase n=3 Tax=Sphingobacteriales RepID=A6EER4_9SPHI Length = 502 Score = 445 bits (1145), Expect = e-123, Method: Compositional matrix adjust. Identities = 234/497 (47%), Positives = 323/497 (64%), Gaps = 1/497 (0%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 +V +FDTTLRDGEQ LS EK++IA ALE +GVDV+E GFP+SSPGDF+SV +++ Sbjct: 7 RVYVFDTTLRDGEQVPGCQLSTPEKIEIAKALEALGVDVIEAGFPISSPGDFQSVVEMSK 66 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 V+ +CAL R + DID A +L+ A+ RIHT I +S MHI K ST ++++ERA+ Sbjct: 67 AVQEPIICALTRANKGDIDSAVAALQYAKRPRIHTGIGSSDMHIKYKFNSTREKILERAV 126 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 VK A+ + +D+EF EDAGR LA++VEA I AGAT +NIPDT GY +P ++ Sbjct: 127 DAVKYAKQFVEDIEFYAEDAGRADNVFLAQMVEAVIAAGATVVNIPDTNGYCLPDQYGSK 186 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 I L E V NID+AIISVH H+DLGLA N+LA + GARQ+E +NGIGERAGN +LEE Sbjct: 187 ILYLKENVKNIDQAIISVHCHNDLGLATANTLAGIVNGARQIECTINGIGERAGNTALEE 246 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 V+M +K L ++T IN + S +VS++ MP+ NKAI+G AFAHSSGIHQDG Sbjct: 247 VVMILKTHH-ALGLNTNINAKHFSDISNMVSRMMRMPVQPNKAIIGQNAFAHSSGIHQDG 305 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 LK+RENYEIM PE +G+N + LT+RSGR A+KH ++ +GY+ NLD +Y+ FL L Sbjct: 306 FLKHRENYEIMNPEDVGINSADIILTARSGRHALKHHLERLGYEIERLNLDQVYERFLIL 365 Query: 364 ADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAA 423 AD+K + D D+ +L GK+ ++L V G TA++KL K A Sbjct: 366 ADEKKAISDDDIHSLMSDGKEDSYKNGYKLTLLQVLCGDPLSPTASIKLEHNGVEKEAMA 425 Query: 424 NGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATD 483 +GNGPV+A AI I ++EL ++++ A G D + +V+I G+ + G G +TD Sbjct: 426 SGNGPVNATINAIQSIVGADIELKEFTIQAVNGGSDDVSKVNIRIASEGKSYVGHGFSTD 485 Query: 484 IVESSAKAMVHVLNNIW 500 IV++SA A + +N Sbjct: 486 IVKASAYAYLDAMNKFM 502 >UniRef50_A4YZ76 2-isopropylmalate synthase n=131 Tax=root RepID=LEU1_BRASO Length = 525 Score = 445 bits (1144), Expect = e-123, Method: Compositional matrix adjust. Identities = 232/496 (46%), Positives = 321/496 (64%), Gaps = 1/496 (0%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 +V+IFDTTLRDGEQ A+++ +EKL IA L+ MGVD++E GFP++S GDFE+V IA+ Sbjct: 11 RVVIFDTTLRDGEQCPGATMTFEEKLNIAAMLDDMGVDIIEAGFPIASDGDFEAVNEIAK 70 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 + KN+ +C L+R KDID AE+++ A+ RIHTF++TSP+H+ KL+ +V E I Sbjct: 71 RSKNAVICGLSRAGAKDIDRCAEAIRPAKRGRIHTFLSTSPVHMKYKLQMDPQQVFELVI 130 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 V RARN+TDDVE+S ED RT L R VEAAI AGA+TINIPDTVGY +P E+ + Sbjct: 131 SSVTRARNHTDDVEWSSEDGTRTEFDFLCRCVEAAIKAGASTINIPDTVGYAVPEEYYDL 190 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 + E VPN DKA+ SVH H+DLG+AV NS+A V AGARQ+E +NGIGERAGN +LEE Sbjct: 191 FKRVRETVPNSDKAVFSVHCHNDLGMAVANSMAGVRAGARQIECTINGIGERAGNAALEE 250 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 V+MA++VR D L I+ ++ S++VS + P+ NKAIVG AFAH SGIHQDG Sbjct: 251 VVMAMRVRNDKLPFWNKIDTTQLTHASKVVSAATSFPVQYNKAIVGRNAFAHESGIHQDG 310 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 +LKN + YEIM PE++G+ Q L + SGR A H+++EMG+K S +++ + F L Sbjct: 311 MLKNAQTYEIMLPETVGVKQTSLVMGKHSGRHAFIHKLEEMGHKLSSNQVEDAFVRFKAL 370 Query: 364 ADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAA 423 AD+K Q++D D+EAL G + +L SV +G+ A +KL + E + Sbjct: 371 ADRKKQIYDEDIEALIDEGMVSAH-DRIKLLSLSVIAGTRGPQRATMKLDIDGVTRIEES 429 Query: 424 NGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATD 483 GNGPVDAV+ I + + +L Y + A G DA +V + + +GR D Sbjct: 430 EGNGPVDAVFNCIKSLVPHEAKLELYQVHAVTEGTDAQAEVSVRLSQDGRSMTARAADPD 489 Query: 484 IVESSAKAMVHVLNNI 499 + +SAKA + LN + Sbjct: 490 TLVASAKAYLGALNKL 505 >UniRef50_A8FFW5 2-isopropylmalate synthase n=224 Tax=Bacilli RepID=LEU1_BACP2 Length = 517 Score = 442 bits (1137), Expect = e-122, Method: Compositional matrix adjust. Identities = 231/497 (46%), Positives = 319/497 (64%), Gaps = 2/497 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ FDTTLRDGEQ+ +L+ +EKL IA LER+GV+++E GFP SS GDF VQ IA Sbjct: 2 RKINFFDTTLRDGEQSPGVNLNAQEKLIIAKQLERLGVNIIEAGFPASSRGDFLGVQEIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 R +KN V LARCV+ DID A E+LK R+H FIATS +H+ KL+ T +EV+E+A Sbjct: 62 RTIKNCSVAGLARCVKGDIDAAWEALKDGVEPRLHVFIATSDIHLKHKLKKTREEVVEQA 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + MVK A+ V++S EDA RT + LA +VE I+AGA+ IN+PDTVGY P E+ Sbjct: 122 VAMVKYAKERFPVVQWSAEDACRTDLDFLAEIVEKVIDAGASVINLPDTVGYLAPKEYGN 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I + E VPNID+ +S H HDDLG+AV NSLAA+ GA Q+E A+NGIGERAGN +LE Sbjct: 182 IFKYMKEHVPNIDRVNLSAHCHDDLGMAVANSLAAIENGADQIETAVNGIGERAGNAALE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E+ +A+ +RKD V + I EI RTS +VS+ M +P NKA+VG+ AFAH SGIHQD Sbjct: 242 EIAVALHIRKDFYQVESTIQLNEIKRTSDVVSKYSGMIVPRNKAVVGNNAFAHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G LK + YEI++PE +G+ L L SGR A K RM +G+K +E ++ ++ F Sbjct: 302 GFLKEKTTYEIISPELVGVTTDVLVLGKHSGRHAFKDRMKTLGFKLTEEEINKFFETFKN 361 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGE--EVKA 420 L +KK ++ D DL ++ K + + + V G+ + TA V L E EV Sbjct: 362 LTEKKKEITDDDLISIILEEKVADRKIGYEFESLQVHYGTEQMPTATVSLKNQETQEVIQ 421 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 EAA G G V+AVY + R E + L+ Y + + G G+DAL +V + + G+ G G+ Sbjct: 422 EAATGAGSVEAVYNTLERCMEERIHLLDYRIQSNGKGRDALAEVYVTVSIEGKETAGRGV 481 Query: 481 ATDIVESSAKAMVHVLN 497 A D++E+SAKA V+ +N Sbjct: 482 AQDVLEASAKAYVNAVN 498 >UniRef50_Q5F8D4 2-isopropylmalate synthase n=73 Tax=cellular organisms RepID=LEU1_NEIG1 Length = 517 Score = 441 bits (1135), Expect = e-122, Method: Compositional matrix adjust. Identities = 236/504 (46%), Positives = 331/504 (65%), Gaps = 7/504 (1%) Query: 1 MSQ--QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESV 58 M+Q +VIIFDTTLRDGEQ+ A+++ +EK+++A LE++G D++E GF +SPGDFE+V Sbjct: 1 MTQANRVIIFDTTLRDGEQSPGAAMTKEEKIRVARQLEKLGADIIEAGFAAASPGDFEAV 60 Query: 59 QTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEV 118 IA+ + S VC+L+R +E+DI A +++ A RIHTFIATSP+H+ KL+ +V Sbjct: 61 NAIAKTITKSTVCSLSRAIERDIRQAGKAVAPAPKKRIHTFIATSPIHMEYKLKMKPKQV 120 Query: 119 IERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 IE A+ VK AR YTDDVEFSCEDA R+ I LA + A I AGATTINIPDTVGY++P+ Sbjct: 121 IEAAVKAVKIAREYTDDVEFSCEDALRSQIDFLAEICGAVIEAGATTINIPDTVGYSIPY 180 Query: 179 EFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGN 238 + L + PN K + S H H+DLGLAV NSLAA+ GARQVE +NG+GERAGN Sbjct: 181 KTEEFFRELIAKTPNGGKVVWSAHCHNDLGLAVANSLAALKGGARQVECTVNGLGERAGN 240 Query: 239 CSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSG 298 S+EE++MA+KVR D+ + T I+ +I +S+LVS I P+ NKAIVG+ AF+H SG Sbjct: 241 ASVEEIVMALKVRHDLFGLETGIDTTQIVPSSKLVSTITGYPVQPNKAIVGANAFSHESG 300 Query: 299 IHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK-ESEYNLDNLY 357 IHQDGVLK+RE YEIM+ ES+G + +L+L SGR A K ++ ++G + ESE L+ + Sbjct: 301 IHQDGVLKHRETYEIMSAESVGWSANRLSLGKLSGRNAFKTKLADLGIELESEEALNAAF 360 Query: 358 DAFLKLADKKGQVFDYDLEALAF--IGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACG 415 F +LADKK ++FD DL AL +G E F S ++G A + G Sbjct: 361 ARFKELADKKREIFDEDLHALVSDEMGNMNAESYKFISQKISTETGEEPRADIVFGIK-G 419 Query: 416 EEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRF 475 EE +A +A G+GPVDA+++AI + + L YS+ A G ++ G+ + R Sbjct: 420 EEKRA-SATGSGPVDAIFKAIESVAQSGATLQIYSVNAVTQGTESQGETSVRLARGNRVV 478 Query: 476 HGVGLATDIVESSAKAMVHVLNNI 499 +G G TDI+ ++AKA + L+ + Sbjct: 479 NGQGADTDILAATAKAYLSALSKL 502 >UniRef50_B7GH19 2-isopropylmalate synthase n=98 Tax=cellular organisms RepID=LEU1_ANOFW Length = 514 Score = 441 bits (1134), Expect = e-122, Method: Compositional matrix adjust. Identities = 241/514 (46%), Positives = 337/514 (65%), Gaps = 3/514 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ IFDTTLRDGEQ+ +L++ EKL+IA LER+GVD++E GFP +S GDF++VQ IA Sbjct: 2 RKINIFDTTLRDGEQSAGVNLNLHEKLEIARQLERLGVDIIEAGFPAASKGDFQAVQAIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 + V+N V L+R V+ DID A E+LK R+H FIATSP+H+ KLR T ++V+E A Sbjct: 62 QTVRNCSVTGLSRSVQSDIDAAWEALKDGAEPRLHVFIATSPIHMQYKLRMTPEQVVETA 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + V+ A+ Y V++S EDA R+ + LA +VE I AGA INIPDTVGY P ++ Sbjct: 122 VESVRYAKKYFPIVQWSAEDACRSDLPFLATIVEKVIEAGANVINIPDTVGYITPKQYGD 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I S L + V NI+K +S H HDDLG+AV NSLAA+ AGA Q+EG +NGIGERAGN ++E Sbjct: 182 IFSFLKKNVRNIEKISLSAHCHDDLGMAVANSLAAIEAGATQIEGTINGIGERAGNAAIE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV +A+ +RKD T +N QEI RTS LVS++ M +PANKAIVG AFAH SGIHQD Sbjct: 242 EVAVALYIRKDYYQAETRLNLQEIKRTSSLVSKLTGMIVPANKAIVGKNAFAHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 GVLK + YEI++P+ +G+ + L SGR A + R+ E+GY +E ++ L+ F Sbjct: 302 GVLKEKTTYEIISPQLVGVQSNSMVLGKHSGRHAFRTRIQELGYSLTEEEVNRLFVRFKD 361 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGE--EVKA 420 LADKK + D DL AL K ++L VQ G+N I TA V L GE +++ Sbjct: 362 LADKKKDITDDDLIALILDEKLDTYKNFYQLCSIQVQYGTNQIPTAVVVLKDGEGNDIQ- 420 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 EAA G G V+A+Y A+ + + V L+ Y + + G G+DAL QV + + + + G G Sbjct: 421 EAATGAGSVEALYNALEKALQLPVTLLDYRIESVGSGRDALAQVYVKVSLDRKEASGRGT 480 Query: 481 ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQ 514 A D++E+SAKA +H +N ++ ++++E AQ Sbjct: 481 AQDVLEASAKAYIHAVNRMFVIEKMKEEQALAAQ 514 >UniRef50_UPI0001C31767 2-isopropylmalate synthase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31767 Length = 528 Score = 439 bits (1130), Expect = e-121, Method: Compositional matrix adjust. Identities = 238/499 (47%), Positives = 322/499 (64%), Gaps = 2/499 (0%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 QV+IFDTTLRDGEQ+ SL+ EKL+IA L R+GVD++E GFP++SPGDFE+V+TIAR Sbjct: 10 QVLIFDTTLRDGEQSPGISLNTSEKLEIAQQLARLGVDIVEAGFPIASPGDFEAVETIAR 69 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 QV+ + LAR DID A +L+ A RIHTF++TS +HI ++RST ++VI Sbjct: 70 QVEGPVIAGLARIHVGDIDAAWNALRDASRPRIHTFVSTSDIHIEHQMRSTREDVIGLTR 129 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 V A+ Y DDVEFS DA R+ + A VV+ AI+ GATTINIPDTVGYTMP E+ Sbjct: 130 AGVAHAKQYVDDVEFSPMDATRSDVEFTAEVVQIAIDEGATTINIPDTVGYTMPHEYTAF 189 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 + LYE P + ++SVH HDDLGLAV NS A V AGARQVE A+NG+GERAGN SLEE Sbjct: 190 LGRLYELAPGLRDVVLSVHCHDDLGLAVANSFAGVLAGARQVECAINGLGERAGNASLEE 249 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 ++M ++ R+ + + T QEI R S+LVS++ + NKAIVG AFAH SGIHQDG Sbjct: 250 IVMLLRTRQADIGLDTNAVSQEIARASRLVSRMTGYAVQPNKAIVGRNAFAHESGIHQDG 309 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 VLKNRE +EIM SIGL+ L L SGR A++ + ++G L+ + F ++ Sbjct: 310 VLKNRETFEIMDATSIGLDSNSLVLGKHSGRHALRDALAQLGIVVDGATLNTAFKRFKEI 369 Query: 364 ADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAA 423 ADKK QV DLEAL + +EE + L++F V++ S A V + + +A + Sbjct: 370 ADKKKQVTAMDLEAL-VTDELREEIPAYALEWFEVEASSRRPPHARVGVTLPDGSEATGS 428 Query: 424 -NGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLAT 482 G+GP+DAV+ AIN T +L + + A G+DALG+ +V +G G G++T Sbjct: 429 FTGDGPIDAVFHAINAATSVEAKLRDFRIDAVTSGQDALGETSVVLEVDGVSGAGQGVST 488 Query: 483 DIVESSAKAMVHVLNNIWR 501 DI+E++ +A V L+N R Sbjct: 489 DIIEAAGRAYVRALSNAVR 507 >UniRef50_A3PDH0 2-isopropylmalate synthase n=42 Tax=cellular organisms RepID=LEU1_PROM0 Length = 546 Score = 439 bits (1129), Expect = e-121, Method: Compositional matrix adjust. Identities = 239/513 (46%), Positives = 336/513 (65%), Gaps = 19/513 (3%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 +++IFDTTLRDGEQ+ ASL+++EKL IA L R+GVDV+E GFP +SPGDF++V IA Sbjct: 7 RILIFDTTLRDGEQSPGASLNLEEKLAIAHQLARLGVDVIEAGFPFASPGDFKAVNKIAS 66 Query: 64 QV---KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 V +C LAR + DI E++ A RIHTFIATS +H+ KL+ + +V++ Sbjct: 67 AVGKEHGPTICGLARASKGDIKACYEAVSPAPKKRIHTFIATSDIHLKHKLKKSRKDVLQ 126 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 MV A++ DD+EFSCEDA R+ L V++ AI+AGATTINIPDTVG+T P EF Sbjct: 127 IVPEMVNYAKSLVDDIEFSCEDASRSDPDFLYEVIQLAISAGATTINIPDTVGFTTPSEF 186 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 +I+ + + VPNID+A+ISVH H+DLGLAV N L AV GARQ+E +NGIGERAGN S Sbjct: 187 GNLIADINKNVPNIDEAVISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAS 246 Query: 241 LEEVIMAIKVRKDILNVH-----------TAINHQEIWRTSQLVSQICNMPIPANKAIVG 289 LEE++MA+ VRK N TAI +EI +TS+LVS + M + NKAIVG Sbjct: 247 LEELVMALHVRKSFFNSFFKRNPDSPTPLTAIRTEEITKTSRLVSNLTGMTVQPNKAIVG 306 Query: 290 SGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKES 349 + AFAH SGIHQDGVLKNR YEI+ +++GL+ +++L SGR+AV+ R++EMGY S Sbjct: 307 ANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNKISLGKLSGRSAVRARLEEMGYDLS 366 Query: 350 EYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPE-HFRLDYFSVQSGSNDIATA 408 +L++ + F LAD+K ++ D DLEA+ + +Q + PE F+L V G+ TA Sbjct: 367 REDLNDAFARFKDLADRKREITDRDLEAI--VSEQVQLPEAKFQLSLVQVSCGNASKPTA 424 Query: 409 AVKLACGEEVKAEAAN--GNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDI 466 + L E+ + A G GPVDAV +A+N++ + EL+++S+ + G DALG+V I Sbjct: 425 TISLLNTEDNTEDTAVSIGTGPVDAVCEALNKLAKVPNELIEFSVKSVTEGIDALGEVTI 484 Query: 467 VANYNGRRFHGVGLATDIVESSAKAMVHVLNNI 499 + + + G TD+V ++A A ++ LN + Sbjct: 485 RIRRDNKIYSGHSADTDVVVAAANAYINALNRL 517 >UniRef50_A8V4T9 2-isopropylmalate synthase (Fragment) n=2 Tax=cellular organisms RepID=A8V4T9_9AQUI Length = 432 Score = 439 bits (1129), Expect = e-121, Method: Compositional matrix adjust. Identities = 233/421 (55%), Positives = 301/421 (71%), Gaps = 8/421 (1%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++IIFDTTLRDGEQA S++V+EK+++A LE++GVDV+E GF +S GDFE+V +A Sbjct: 12 RKLIIFDTTLRDGEQAPGFSMTVEEKVRMAKQLEKLGVDVIEAGFAAASKGDFEAVNEVA 71 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 ++VKNS VC+LAR + DI+ A E+L AE RIHTFIATSP+H+ KLR T ++V+ERA Sbjct: 72 KEVKNSTVCSLARALHSDIERAGEALAPAERKRIHTFIATSPIHMEYKLRMTPEQVLERA 131 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + V+ ARN+TDDVEFS EDA R+ L R+ EA I AGA TIN+PDTVGY +P EF Sbjct: 132 VDAVQFARNFTDDVEFSAEDAVRSEREFLYRIFEAVIAAGAKTINVPDTVGYAVPEEFGQ 191 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 +IS + VPNIDKA+ISVH H+DLGLAV NSL AV GA QV +NGIGERAGN +LE Sbjct: 192 LISDILNNVPNIDKAVISVHCHNDLGLAVANSLTAVKNGAGQVHSTINGIGERAGNAALE 251 Query: 243 EVIMAIKVRKDIL-NVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EV+MAIKVRKD +V+T IN +EI+RTS+L+ ++ + NKAIVG AFAH +GIHQ Sbjct: 252 EVVMAIKVRKDYFKDVYTDINTKEIYRTSRLLCRLTGSFVQPNKAIVGDNAFAHEAGIHQ 311 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE-SEYNLDNLYDAF 360 G+L RE YEIM E +G+ ++ L SGR A K R++E+GYK SE +D L+ F Sbjct: 312 HGLLAKRETYEIMKAEDVGVPSSKIVLGKHSGRHAFKTRLEELGYKNLSEEEIDKLFAKF 371 Query: 361 LKLADKKGQVFDYDLEALAF--IGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLAC-GEE 417 +LADKK +VFD D+EAL F + K EE +L F + SG+ I TA VKL GEE Sbjct: 372 KELADKKKEVFDEDIEALLFDELFKSYEE---VKLLQFQIVSGNKAIPTATVKLKIDGEE 428 Query: 418 V 418 + Sbjct: 429 I 429 >UniRef50_D2M1E9 2-isopropylmalate synthase n=1 Tax=Bacillus cellulosilyticus DSM 2522 RepID=D2M1E9_BACS4 Length = 514 Score = 435 bits (1119), Expect = e-120, Method: Compositional matrix adjust. Identities = 231/499 (46%), Positives = 319/499 (63%), Gaps = 2/499 (0%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 ++ IFDTTLRDGEQ+ +L+ EKL+IA LER GVD+ME GFP SS GDFE V+ IA Sbjct: 3 KINIFDTTLRDGEQSPGVNLNQLEKLEIAKQLERFGVDIMEAGFPASSQGDFEGVRAIAN 62 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 +KN+ V LAR + DID A ++LK A R+H F+ATSP+H+ KL+ T ++VI+ A+ Sbjct: 63 TIKNASVTGLARAKKSDIDYAWDALKEAVEPRLHIFLATSPIHMTYKLKKTPEQVIQTAV 122 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 MV A VE+S EDA R+ I L +++E I+AGAT IN+PDTVGYT P E+ + Sbjct: 123 DMVSYASKNFPHVEWSAEDASRSDIHFLVKIIEKVIDAGATVINLPDTVGYTTPQEYGDL 182 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 + E V NIDK +S H HDDLG+AV N++AAV GA QVEG +NGIGERAGN SLEE Sbjct: 183 FKYVRENVRNIDKVTLSAHCHDDLGMAVANTIAAVENGATQVEGTINGIGERAGNASLEE 242 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 + +A+ +R D T + EI RTS LVS++ M +P NKA+VG AFAH SGIHQDG Sbjct: 243 IAVALNIRSDKYPYTTNLVLNEIKRTSDLVSKLTGMVVPPNKAVVGRNAFAHESGIHQDG 302 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 VLKN YEI+TPE +G+ L L SGR A K +++++GY+ +E L + +F L Sbjct: 303 VLKNASTYEIITPELVGIQSNNLVLGKHSGRHAFKDKIEQLGYELAEDKLLEAFQSFKLL 362 Query: 364 ADKKGQVFDYDL-EALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEA 422 D+K +V D DL L I + + + L+ F VQ GS+++ TA V L E + E Sbjct: 363 TDRKKEVTDDDLFTILTDIQTDTSDVKKYELEAFQVQYGSSNLPTATVALTTPEGERVET 422 Query: 423 A-NGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLA 481 A G+G V+A+Y + + + + L ++L++ G G+DAL V I N G G A Sbjct: 423 ACTGSGSVEALYNTLEALIKEKIHLTDFNLSSVGQGRDALADVHIKMTVNDTPVSGRGTA 482 Query: 482 TDIVESSAKAMVHVLNNIW 500 D++E+SAKA ++ +N ++ Sbjct: 483 QDVLEASAKAFLNAVNRVF 501 >UniRef50_A7Z7B8 2-isopropylmalate synthase n=11 Tax=Bacillales RepID=LEU1_BACA2 Length = 518 Score = 431 bits (1108), Expect = e-119, Method: Compositional matrix adjust. Identities = 227/497 (45%), Positives = 319/497 (64%), Gaps = 2/497 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ +FDTTLRDGEQ+ +L+ +EKL IA LER+GVD++E GFP SS GDF +VQ IA Sbjct: 2 RKINVFDTTLRDGEQSPGVNLNSREKLAIAKQLERLGVDIIEAGFPASSRGDFLAVQEIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 R +KN V LAR V+ DID A E+LK + RIH FIATS +H+ KL+ T +EV E+A Sbjct: 62 RTIKNCSVTGLARSVKGDIDAAWEALKDGVSPRIHIFIATSDIHLKHKLKMTREEVKEKA 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + MVK A+ V++S EDA RT + LA +VE I+AGA+ IN+PDTVGY P E+ Sbjct: 122 VEMVKYAKERFPIVQWSAEDACRTELPFLAEIVEEVIDAGASVINLPDTVGYLTPDEYGN 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I + E VPNI + +S H HDDLG+AV NSL+A+ GA Q+E A+NGIGERAGN +LE Sbjct: 182 IFKYMKEHVPNISRVKLSAHCHDDLGMAVANSLSAIENGADQIECAINGIGERAGNAALE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E+ +A+ VR D +++N E+ RTS LVS++ M +P NKAIVG AFAH SGIHQD Sbjct: 242 EIAVALHVRNDAHQADSSLNLHELKRTSDLVSKLTGMAVPRNKAIVGDNAFAHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G LK + YEI++PE +G+ L L SGR A K R++ +G++ ++ + F + Sbjct: 302 GFLKEKSTYEIISPELVGVTADALVLGKHSGRHAFKDRLNTLGFQFDSDEINKYFTMFKE 361 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLAC--GEEVKA 420 L +KK ++ D DL +L K ++ + V G++ + TA V L E++ Sbjct: 362 LTEKKKEITDDDLISLILEEKVTDKKIGYEFLSLQVHYGTSQVPTATVSLKNQENEQLMQ 421 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 EAA G G V+AVY + R + N+EL Y + + G+DAL QV + NG+ G G+ Sbjct: 422 EAATGAGSVEAVYNTLGRCIDKNIELTDYRIQSNRKGEDALAQVFVRVTVNGKESSGRGI 481 Query: 481 ATDIVESSAKAMVHVLN 497 A D++E+SAKA ++ +N Sbjct: 482 AQDVLEASAKAYLNAVN 498 >UniRef50_Q2S0M7 2-isopropylmalate synthase n=3 Tax=Bacteria RepID=Q2S0M7_SALRD Length = 546 Score = 430 bits (1105), Expect = e-119, Method: Compositional matrix adjust. Identities = 237/528 (44%), Positives = 321/528 (60%), Gaps = 24/528 (4%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 MS + IFDTTLRDGEQA AS++V EK+ IA L + VDV+E GFP+SSP E+V Sbjct: 1 MSDSITIFDTTLRDGEQAPGASMTVPEKVHIAHKLADLNVDVIEAGFPISSPAQTEAVTR 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATK---LRSTLDE 117 IA +V CALAR E DID A E+L R+HTFIATS +HI K L +T+ E Sbjct: 61 IATEVDGPVTCALARTKEDDIDAAGEALADGTDTRLHTFIATSDVHIEAKFDKLGNTMAE 120 Query: 118 ----VIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVG 173 +I+RA+ +++A YTD+VEFS EDAGRT L VV+AA AGATTINIPDT G Sbjct: 121 KREAIIQRAVRAIEQALTYTDNVEFSAEDAGRTDPEFLCEVVQAAAEAGATTINIPDTTG 180 Query: 174 YTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIG 233 Y P E+ ++ + + +P+ D +S H HDDLGLA N+LA + AGARQVE +NGIG Sbjct: 181 YCAPSEYTDLLETVVDCLPDPDAVTLSTHCHDDLGLATANTLAGIRAGARQVECTINGIG 240 Query: 234 ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAF 293 ERAGN +LEE++MA+ VR D +V ++ + + TSQ VS P+ NKAIVGS AF Sbjct: 241 ERAGNAALEEIVMALTVRADAFDVTADVHTEHLTPTSQTVSAATGFPVQPNKAIVGSNAF 300 Query: 294 AHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNL 353 +H +GIHQ GVL+ R YEIM+ +G + Q+ L SGR + +R++ MGY E + Sbjct: 301 SHEAGIHQHGVLEERTTYEIMSATDVGQDAEQIRLGRHSGRHGLFNRLEAMGYAVPEGHR 360 Query: 354 DNLYDAFLKLADKKGQVFDYDLEALA------FIGKQQEEPEH----------FRLDYFS 397 D LYD FL LAD+K +VF+ DLE + + P++ +RLD FS Sbjct: 361 DALYDRFLDLADRKKEVFEEDLEQMMNDFGGDAVAAATGLPDNGVALNGGTPAYRLDQFS 420 Query: 398 VQSGSNDIATAAVKLACGE-EVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGH 456 V S+D A +V+L + + E A G GPVDA+Y+A++ + LV YS+ + Sbjct: 421 VHLSSDDEAKVSVRLQRDDGSAREEQATGEGPVDALYRALDHAVDAPHTLVDYSIRSISE 480 Query: 457 GKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAE 504 G DA G+V++ Y +F G TD++ +SA+A V LN + A E Sbjct: 481 GADAQGEVEVTIRYGENQFAGTARNTDVIRASAEAYVDALNRLVAAQE 528 >UniRef50_Q72JC9 2-isopropylmalate synthase n=4 Tax=Thermaceae RepID=Q72JC9_THET2 Length = 520 Score = 421 bits (1083), Expect = e-116, Method: Compositional matrix adjust. Identities = 232/493 (47%), Positives = 314/493 (63%), Gaps = 4/493 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + + IFDTTLRDGEQ+ +LS+ +KL+IA AL ++ VD++E GFPVS P +FE+V+ IA Sbjct: 5 RHIRIFDTTLRDGEQSPGVALSLDQKLEIAQALAQLNVDIIEAGFPVSGPMEFEAVRRIA 64 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 +VK + ALAR DID AA++L+ AE RIH F + S +H+ LR T +EV+E A Sbjct: 65 TEVKGPIIAALARTHTLDIDQAAKALEKAEKPRIHVFTSASKVHLQYMLRKTEEEVLEMA 124 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 MV+ AR Y DDVEFS +D R + R+ E AI AGATTINIPDT GY P E+ Sbjct: 125 DRMVRYARRYVDDVEFSAQDVMRADWEFVKRLYEVAIEAGATTINIPDTTGYGTPQEYGA 184 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 +I + + V IIS HTHDDLG+A N+LA V GA Q+E +NGIGERAGNC+LE Sbjct: 185 LIRRIRDEVVRGRDVIISTHTHDDLGMATANALAGVENGAGQIECTINGIGERAGNCALE 244 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV+MA+ VR+D +T IN +EI+R S+LV + MP+P NKAIVG AFAH SGIHQD Sbjct: 245 EVVMALYVRRDWYKAYTRINTREIYRVSRLVERYTGMPVPPNKAIVGDNAFAHESGIHQD 304 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE-SEYNLDNLYDAFL 361 GV+K+R YEIM E IG L L SGRAA K ++++GYK+ SE + L+ F Sbjct: 305 GVIKHRATYEIMDAELIGRRPAVLVLGKHSGRAAFKKALEDLGYKDLSEEEVKKLFARFK 364 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPEH-FRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 ++A+KKG + +L+AL + ++E H F+L++ SGS + TA VK+ + + Sbjct: 365 EIAEKKGPLSAEELQAL--VESEREPTSHFFQLEHVQFFSGSGLLPTATVKVKTPDGERV 422 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 G+GPVDAVY+AI EL Y + A +ALGQV + + GVG+ Sbjct: 423 ATHTGDGPVDAVYKAIQEAIGLRPELELYRVEAITGSTEALGQVTVRLRLGELQAVGVGV 482 Query: 481 ATDIVESSAKAMV 493 + DI+E+SA A + Sbjct: 483 SPDIIEASALAFL 495 >UniRef50_D0MYD7 2-isopropylmalate synthase n=2 Tax=Phytophthora infestans T30-4 RepID=D0MYD7_PHYIN Length = 576 Score = 415 bits (1067), Expect = e-114, Method: Compositional matrix adjust. Identities = 243/534 (45%), Positives = 331/534 (61%), Gaps = 39/534 (7%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++++FDTTLRDGEQ+ A+L+ KEKL IA AL +GVDV E GFP+SSPGDF++V IA Sbjct: 32 ERLVLFDTTLRDGEQSPGATLNFKEKLDIARALSTLGVDVCEAGFPISSPGDFDAVSAIA 91 Query: 63 RQV----------KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLR 112 +++ + +C LAR +EKDI +++K A RIHTF+ATS +H+ KL+ Sbjct: 92 KEIGPITAGRPTGEPMTICGLARAMEKDIQRCYDAVKHAPKHRIHTFLATSDIHLQYKLK 151 Query: 113 STLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTV 172 + DE I RA+ VK A++ T DVEFS EDAGR+ L V+ I AGATT+NIPDTV Sbjct: 152 ISRDECIRRAVDAVKFAKSLTPDVEFSTEDAGRSDPDFLCDVLAEVIKAGATTLNIPDTV 211 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 GYT+P E+ + S L + DKAI S H H+DLGLA N+LAAV GARQ E +NGI Sbjct: 212 GYTVPGEYGSLFSYLIDNTEGSDKAIFSTHCHNDLGLATANTLAAVQGGARQAEVTINGI 271 Query: 233 GERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 GERAGN +LEE++MA+K R V+T+++ +I R S++VS M I NKAIVGS A Sbjct: 272 GERAGNTALEELVMALKTRPQHFPVYTSVDSTQITRCSRMVSHYTGMSIQPNKAIVGSNA 331 Query: 293 FAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE-SEY 351 FAH SGIHQDGVLK++ YEIM PES+GL++ ++ L SGR A R+ ++GY + Sbjct: 332 FAHESGIHQDGVLKHQATYEIMLPESVGLSENKMVLGKHSGRHAYSKRLQQLGYTNLTPE 391 Query: 352 NLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHF-RLDYFSVQSGSNDIATAAV 410 LD + F LAD+K V D D+EA+ + + +PE F L V +G+ TA V Sbjct: 392 ELDYYVEKFKVLADEKKTVTDADMEAI--VSDELFKPETFWTLQSVHVTAGNLVKPTATV 449 Query: 411 KLAC--GEEVKAEAANGNGPVDAVYQAINRITEY-NVELVKYSLTAKGHGKDALGQVDI- 466 LA G+EV +EAA G GP+DA+Y AI R T +++L +S+ + G ALG+V + Sbjct: 450 TLAHKDGQEV-SEAAMGTGPIDAIYVAIKRATGMESIKLNDFSVESVTDGTYALGEVTVR 508 Query: 467 ----------------VANYNG----RRFHGVGLATDIVESSAKAMVHVLNNIW 500 V G R+F G G TDI+ +SA A V+ +N + Sbjct: 509 VQEDKEEEEKTEGEKHVNAQTGVTRDRQFVGHGANTDILVASATAYVNAVNRMM 562 >UniRef50_A2C859 2-isopropylmalate synthase n=16 Tax=Bacteria RepID=LEU1_PROM3 Length = 540 Score = 415 bits (1066), Expect = e-114, Method: Compositional matrix adjust. Identities = 250/513 (48%), Positives = 336/513 (65%), Gaps = 20/513 (3%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 +V+IFDTTLRDGEQ+ ASL+++EKL IA L R+GVDV+E GFP +S GDF +VQ IA+ Sbjct: 7 RVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDVIEAGFPFASQGDFSAVQRIAQ 66 Query: 64 QVKNSR---VCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 QV +C LAR DI A+++ A RIHTFIATS +H+ KLR + EV+ Sbjct: 67 QVGGDEGPIICGLARASRADIKACADAVAPAPRRRIHTFIATSDIHLEHKLRKSRAEVLA 126 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 MV AR+ DDVEFSCEDA R+ L V+EAAI AGA TINIPDTVG+T P EF Sbjct: 127 IVPEMVAYARSLVDDVEFSCEDAARSDPEFLYEVIEAAIAAGAGTINIPDTVGFTTPSEF 186 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 +I+G+ VPN+++AI+SVH H+DLGLAV N L AV +GARQ E +NGIGERAGN + Sbjct: 187 GALIAGIDCHVPNMNEAILSVHGHNDLGLAVANFLEAVKSGARQFECTINGIGERAGNAA 246 Query: 241 LEEVIMAIKVRKDILNVH-----------TAINHQEIWRTSQLVSQICNMPIPANKAIVG 289 LEE++MA+ VR+ N TA+ +EI +TS+LVS + M + NKAIVG Sbjct: 247 LEELVMALYVRRRYFNPFFGRESDSPTPLTAVRTEEITKTSRLVSNLTGMVVQPNKAIVG 306 Query: 290 SGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKES 349 S AFAH SGIHQDGVLKNR YEI+ ++GL +++L SGR+AV+ R++E+GY + Sbjct: 307 SNAFAHESGIHQDGVLKNRLTYEIVDARTVGLTDNRISLGKLSGRSAVRARLEELGYDLT 366 Query: 350 EYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPE-HFRLDYFSVQSGSNDIATA 408 +LD + F LAD+K + D DLEA+ + +Q ++PE F+L V GS+ TA Sbjct: 367 REDLDEAFARFKDLADRKRDITDRDLEAI--VSEQVQQPEARFQLRLVQVSCGSSLRPTA 424 Query: 409 AVKLAC--GEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDI 466 V LA G+E A AA G GPVDAV +A+N + EL+++S+ + G DA+G+V I Sbjct: 425 TVILAQEDGQEQTA-AAVGTGPVDAVCRALNALAGEPNELIEFSVKSVTEGIDAMGEVTI 483 Query: 467 VANYNGRRFHGVGLATDIVESSAKAMVHVLNNI 499 +G+ F G TD+V ++A+A V+ LN + Sbjct: 484 RLRRDGQLFSGHSADTDVVVAAAQAFVNALNRL 516 >UniRef50_A3DF94 2-isopropylmalate synthase n=3 Tax=Clostridium thermocellum RepID=A3DF94_CLOTH Length = 511 Score = 410 bits (1053), Expect = e-113, Method: Compositional matrix adjust. Identities = 221/495 (44%), Positives = 315/495 (63%), Gaps = 5/495 (1%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ IFDTTLRDGEQ +L+++EK+ IA L R+GVDV+E GFP++SPGDFE+VQ IA Sbjct: 2 RRIRIFDTTLRDGEQTPGVNLNIQEKVDIAKQLARLGVDVIEPGFPLTSPGDFEAVQRIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 R+V+ +C +R + +DID +++K A+ H FI++S + I +L T +V+E Sbjct: 62 REVEGPYICGFSRAIIRDIDETWKAIKDAQKKCFHIFISSSDIQIKHQLGKTEKDVLEIV 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 V A+ YTD+VE+S DA RT + L V+EAAI+ GAT INIPDTVGY P EF Sbjct: 122 KSTVYHAKQYTDEVEYSPMDASRTRLEFLYEVIEAAIDNGATVINIPDTVGYATPIEFGE 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 +I + + V NIDKAIISVH H+DLG+AV NS+ A GA+Q+E +NG+GERAGN +LE Sbjct: 182 LIQKIRKNVRNIDKAIISVHCHNDLGMAVANSIVAAMNGAQQIECTINGVGERAGNAALE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV+ I RKD L T I+ ++++TS++VS+ +PIP NK IVG F H SGIHQD Sbjct: 242 EVVTHIAARKDYLGFETGIDLSQLYKTSKIVSRYMGIPIPVNKPIVGKNVFTHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 GVLK R YE++ P +G + + L SGR A+K +++GY E L+ L++ F K Sbjct: 302 GVLKERSTYEVIDPRLVGRDDSVILLGKHSGRHALKVEAEKLGYDLDEERLNKLFNDFKK 361 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAV--KLACGEEVKA 420 L D K V DLE+L + E + L+ V SG+ + +A V K + G ++A Sbjct: 362 LTDVKKNVTTADLESLIIESAAKAVEEAYVLEKIRVVSGNIETPSAKVVIKDSKGNLLEA 421 Query: 421 EAANGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGV 478 E GNGPVDAV++AIN + + N+ L KYS++A ++LG+V + + + G+ Sbjct: 422 E-QTGNGPVDAVFKAINSVIKETENLTLYKYSVSAVTEEMESLGEVSVTLREKEKLYTGI 480 Query: 479 GLATDIVESSAKAMV 493 G TDI+ SSA A + Sbjct: 481 GTHTDIITSSAIAYI 495 >UniRef50_C7JAV8 2-isopropylmalate synthase n=8 Tax=Acetobacter pasteurianus RepID=C7JAV8_ACEP3 Length = 547 Score = 407 bits (1046), Expect = e-112, Method: Compositional matrix adjust. Identities = 232/509 (45%), Positives = 316/509 (62%), Gaps = 7/509 (1%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 +VI+FDTTLRDGEQ+ S+++ EKL++A AL +GVDV+E GFPV+S GDFESV IA+ Sbjct: 38 RVIVFDTTLRDGEQSPGFSMNLAEKLRMAEALANLGVDVIEAGFPVASKGDFESVNEIAK 97 Query: 64 QVKNSRVCALARCVE-KDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 K S +CALAR KDI A E+L AE RIH FI+TSP+H+ KLR + V+E Sbjct: 98 NTKGSVICALARSGGVKDIAAAGEALAPAERKRIHNFISTSPLHMKYKLRMEPETVLELI 157 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 ARN TDDVE+S ED RT L R VEAAI AGATTINIPDTVGY P + Sbjct: 158 TSGNAAARNLTDDVEWSAEDGSRTEPDFLCRCVEAAIKAGATTINIPDTVGYATPEDMEK 217 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I S L +RVP D+ I S H H+DLGLAV N+LA++ GARQVE +NGIGERAGN +LE Sbjct: 218 IFSMLRQRVPGADQVIFSAHNHNDLGLAVANTLASIRGGARQVECTINGIGERAGNAALE 277 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E++MA++ R D T I+ + + + S++++ I + + NKAIVG AFAH SGIHQD Sbjct: 278 EIVMALRTRHDQYPFTTGIHTEGLLKVSRMLATITSFDVQPNKAIVGRNAFAHESGIHQD 337 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK-ESEYNLDNLYDAFL 361 GVLKN YEIMTPES+G + L + SGRAA + ++ +GY+ E L+ + F Sbjct: 338 GVLKNAATYEIMTPESVGWTRSSLVMGKHSGRAAFRDKLKVLGYEGMDETRLNEAFTRFK 397 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLAC-GEEVKA 420 LAD+K V+D D+ +A + + + + R S++S S + ++L+ G+ ++A Sbjct: 398 DLADRKKVVYDDDI--IALVDDEARDHDRIRFGALSLKSISGQPSEVDLELSVDGKAIEA 455 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 + A GNGPVDA + A+ + + L +S+ A G DA + + G+ G G Sbjct: 456 K-ATGNGPVDAAFNALRKAFPHEARLALFSVGAVTEGTDAQARTTVRLEEAGKMVDGQGA 514 Query: 481 ATDIVESSAKAMVHVLNNIW-RAAEVEKE 508 D V S+ +A VH LN + + A E E Sbjct: 515 DADTVVSAVRAYVHALNKLLVKRARTEPE 543 >UniRef50_Q9C550 2-isopropylmalate synthase 2, chloroplastic n=59 Tax=cellular organisms RepID=LEU12_ARATH Length = 631 Score = 402 bits (1032), Expect = e-110, Method: Compositional matrix adjust. Identities = 236/525 (44%), Positives = 327/525 (62%), Gaps = 32/525 (6%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V IFDTTLRDGEQ+ A+L+ KEKL IA L ++GVD++E GFP +S DFE+V+TIA Sbjct: 87 VRIFDTTLRDGEQSPGATLTSKEKLDIARQLAKLGVDIIEAGFPAASKDDFEAVKTIAET 146 Query: 65 VKNSR--------VCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 V N+ +C L+RC +KDI+ A E++K A+ RIHTFIATS +H+ KL+ + + Sbjct: 147 VGNTVDENGYVPVICGLSRCNKKDIETAWEAVKYAKRPRIHTFIATSDIHLKYKLKKSKE 206 Query: 117 EVIERAIYMVKRARNY-TDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYT 175 EVIE A MV+ AR+ +DVEFS EDAGR+ L ++ I AGATT+NIPDTVG T Sbjct: 207 EVIEIARNMVRFARSLGCEDVEFSPEDAGRSEREYLYEILGEVIKAGATTLNIPDTVGIT 266 Query: 176 MPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGER 235 +P EF +I+ + P I IIS H +DLGL+ N+L+ H+GARQVE +NGIGER Sbjct: 267 LPSEFGQLIADIKANTPGIQNVIISTHCQNDLGLSTANTLSGAHSGARQVEVTINGIGER 326 Query: 236 AGNCSLEEVIMAIKVRKD--ILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAF 293 AGN SLEEV+MAIK R D + + T I+ + I TS++V + M +KAIVG+ AF Sbjct: 327 AGNASLEEVVMAIKCRGDHVLGGLFTGIDTRHIVMTSKMVEEYTGMQTQPHKAIVGANAF 386 Query: 294 AHSSGIHQDGVLKNRENYEIMTPESIGL---NQIQLNLTSRSGRAAVKHRMDEMGYKESE 350 AH SGIHQDG+LK++ YEIM+PE IGL N + L SGR A+K R++E+GY + Sbjct: 387 AHESGIHQDGMLKHKGTYEIMSPEEIGLERSNDAGIVLGKLSGRHALKDRLNELGYVLDD 446 Query: 351 YNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEH-FRLDYFSVQSGSNDIATAA 409 L NL+ F +A++K +V D DL +A + + +PE ++L + G+ ++T+ Sbjct: 447 GQLSNLFWRFKAVAEQKKRVTDADL--IALVSDEVFQPEAVWKLLDMQITCGTLGLSTST 504 Query: 410 VKLACGEEVKAEAAN-GNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVA 468 VKLA + + A + G GPVDA Y+A++ I + L++YS+ A G DA+ ++ Sbjct: 505 VKLADSDGKEHVACSVGTGPVDAAYKAVDLIVKEPATLLEYSMNAVTEGIDAIATTRVLI 564 Query: 469 ----NYNG----------RRFHGVGLATDIVESSAKAMVHVLNNI 499 NY+ R F G G DIV SS KA V LN + Sbjct: 565 RGDNNYSSTNAVTGESVERTFSGTGAGMDIVVSSVKAYVGALNKM 609 >UniRef50_B4SI67 2-isopropylmalate synthase n=45 Tax=Xanthomonadaceae RepID=LEU1_STRM5 Length = 528 Score = 397 bits (1020), Expect = e-109, Method: Compositional matrix adjust. Identities = 222/507 (43%), Positives = 315/507 (62%), Gaps = 12/507 (2%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 + ++ IFDTTLRDGEQ+ S+S +KL +A AL+ +GVD++E GFP SS D +++ I Sbjct: 9 TPRIRIFDTTLRDGEQSPGCSMSPPQKLVMARALDELGVDIIETGFPASSQSDRDAMALI 68 Query: 62 ARQVKNSRV--CALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 R+++ + L+RC++ DI+ +A +L+ A R+H F++TSP+H KLR T ++V+ Sbjct: 69 GRELRRPSLSLAVLSRCLQADIETSARALEAAANPRLHVFLSTSPLHREHKLRMTREQVL 128 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE 179 E V AR+Y DDVEFS EDA RT + L V AAI+AGATTIN+PDTVG+T P E Sbjct: 129 ESVRKHVSLARSYIDDVEFSAEDATRTELDYLIEVSRAAISAGATTINLPDTVGFTTPEE 188 Query: 180 ----FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGER 235 F +I+G+ + VPN I S H H+DLGLAV NSLAA+ GARQVE +NGIGER Sbjct: 189 IREMFQQVIAGVAD-VPNAANVIFSAHCHNDLGLAVANSLAAIEGGARQVECTVNGIGER 247 Query: 236 AGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAH 295 AGNCSLEE+ M +KVR+ ++IN I TSQL+ ++ MP+ NKAIVG+ AFAH Sbjct: 248 AGNCSLEEIAMVLKVRQAFYEQDSSINTPRIVGTSQLLQRLVGMPVQRNKAIVGANAFAH 307 Query: 296 SSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDN 355 SGIHQ G+L++R YEIM PE +G Q+ L SGRAAV+ R+ +G+ E L Sbjct: 308 ESGIHQHGMLRHRGTYEIMRPEDVGWEDSQMVLGRHSGRAAVEARLRALGFWLEEDELKL 367 Query: 356 LYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQS-GSNDIATAAVKLAC 414 +++ F L +++ V D DL+ L G + +RL ++ GS A + Sbjct: 368 VFEQFKGLCEQQRVVTDADLQTLMQGGSNA---QGYRLASMTISDVGSRANALVELSDPD 424 Query: 415 GEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRR 474 G V AE A G+GPVDA++ A++ T + L Y + + G G DA G+ ++ + G Sbjct: 425 GNRV-AETAQGDGPVDALFGALSAATGVQLMLDSYHVHSVGIGADARGEANLSVRHEGVE 483 Query: 475 FHGVGLATDIVESSAKAMVHVLNNIWR 501 + G G + DI+E+SA A + V N + R Sbjct: 484 YDGTGTSKDIIEASALAWLDVANRLLR 510 >UniRef50_Q1ARE2 2-isopropylmalate synthase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1ARE2_RUBXD Length = 510 Score = 395 bits (1015), Expect = e-108, Method: Compositional matrix adjust. Identities = 229/491 (46%), Positives = 309/491 (62%), Gaps = 14/491 (2%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ IFDTTLRDGEQ+ SLSV+EK++IA L R+ VDV+E GFP++S GDFE+V IA Sbjct: 2 RRIQIFDTTLRDGEQSPGISLSVEEKVEIAHQLARLKVDVIEAGFPITSEGDFEAVSRIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 +V+ + LAR ++DI+ A E+++ + RIHTF+ TS +HI ++RST +E++ A Sbjct: 62 SEVEGPVIAGLARIHQEDIERAWEAVRWSRRPRIHTFVGTSDLHIEHQMRSTREEILSGA 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 V+ A++ ++VEFS DA RT I LA VV AA+ AGA INI DTVGYT P EFA Sbjct: 122 AEAVRLAKSLCENVEFSPMDATRTDIGYLAEVVAAAVEAGADVINIADTVGYTTPAEFAA 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + L ERVP + + ++SVH HDDLG+AV NSLA V AGA QVE A+NGIGERAGN SLE Sbjct: 182 FLRELKERVPGLAERVLSVHCHDDLGMAVANSLAGVEAGATQVEVAVNGIGERAGNASLE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV+MA+ RKD V + +++ TS++VS + +P NKA+VG AF H SGIHQD Sbjct: 242 EVVMALVTRKDYYGVEVGVETRQLANTSRMVSNMTGYDVPPNKAVVGRNAFLHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 GVLK+R +EIM P IGL + L SGR A+K + ++GY L + F + Sbjct: 302 GVLKDRRTFEIMKPADIGLEGTNIFLGKHSGRHALKEALADLGYTLEGETLKRAFKRFKE 361 Query: 363 LADKKGQVFDYDLEALA------FIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGE 416 LAD K V DLEA+A F GK F L+ F V + + + AAV++A + Sbjct: 362 LADHKKTVTAADLEAIAADEVGSFEGK-------FVLESFRVVAATGRQSRAAVRIAHAD 414 Query: 417 EVKAEA-ANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRF 475 EA A G GPVDAV++AI+ T L + + A GKDALG+V + + G Sbjct: 415 RGTFEAEAEGEGPVDAVFRAIDSATGIKGRLTDFRIDAVTGGKDALGEVRVTVEFEGTEC 474 Query: 476 HGVGLATDIVE 486 G GL+ D+VE Sbjct: 475 AGRGLSQDVVE 485 >UniRef50_C0Z635 Probable 2-isopropylmalate synthase n=1 Tax=Brevibacillus brevis NBRC 100599 RepID=C0Z635_BREBN Length = 514 Score = 393 bits (1010), Expect = e-108, Method: Compositional matrix adjust. Identities = 218/507 (42%), Positives = 312/507 (61%), Gaps = 11/507 (2%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M++++ IFDTTLRDGEQA ASLS ++K+ IA L +GVDV+E GFP+SSPGDF +VQ Sbjct: 1 MTKRIHIFDTTLRDGEQAPGASLSPEQKIVIAKHLADLGVDVIEPGFPISSPGDFMAVQR 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I+++V +C AR V++DID A + + AE R+H F+++S +H+ +LR + ++VI+ Sbjct: 61 ISQEVHGVEICGFARAVKEDIDAAVRATQAAERRRLHMFLSSSSIHLDFQLRKSREQVIK 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 A M+ + + D EFS DA RT L ++EAAI GAT INIPDTVGY +P E+ Sbjct: 121 IAREMIAYGKQFVDRFEFSPMDATRTGDEFLFEMIEAAIEEGATIINIPDTVGYALPEEY 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 + + + + V DK S H H+DLGLAV NSLAA+ AG QVE +NG+GERAGNCS Sbjct: 181 GAMFTRVMKNVRGSDKVEFSAHCHNDLGLAVANSLAAIRAGVTQVEVTVNGVGERAGNCS 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEE++MAI+ RK+ L+ T I + I+ TSQ VS+ + PI NK IVG AF H +GIH Sbjct: 241 LEELVMAIETRKEALDAETRIRPEHIYTTSQKVSRAMSFPIAFNKPIVGRNAFQHEAGIH 300 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 QDG+LK R YEIM PES+G+ + + L SGR A+KHR++E G + ++ ++ LY F Sbjct: 301 QDGLLKERSTYEIMDPESLGVPRNMIILGKHSGRHAIKHRVNEFGIQLTDEQMEALYVQF 360 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQE---EPEHFRLDYFSVQSGSNDIATAAVKL---AC 414 +LADK+ V D+ L L +G EP F L V +G++ A+ + Sbjct: 361 KELADKQKVVQDHQL--LELVGHTVNAVLEP--FTLVNAQVLTGTSGHRMASCTIMNNVT 416 Query: 415 GEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRR 474 GEE +A + G GPV+A+ I + ++VE L + G+ A G+ + + NG Sbjct: 417 GEE-QAYSGTGEGPVEALVAGIKQALPFDVEFTDMELYSLSSGEHATGEAIVTVSANGSH 475 Query: 475 FHGVGLATDIVESSAKAMVHVLNNIWR 501 F GV D++ + A+A + N R Sbjct: 476 FKGVAEHRDVLMAVAQAFMAASNQAVR 502 >UniRef50_A9KRN2 2-isopropylmalate synthase n=8 Tax=Bacteria RepID=A9KRN2_CLOPH Length = 505 Score = 392 bits (1008), Expect = e-107, Method: Compositional matrix adjust. Identities = 210/502 (41%), Positives = 320/502 (63%), Gaps = 7/502 (1%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ +FDTTLRDGEQ A L+ +EK+ IA LE++ VD ME GFP SS GDFE+V+ I+ Sbjct: 2 RKIYVFDTTLRDGEQVPGAKLNFEEKMYIAKQLEKLRVDYMEAGFPSSSQGDFEAVREIS 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 RQ+K+S V AL R V+ DID ESLK A IH + +S +HI K +++++ Sbjct: 62 RQIKDSSVVALGRAVKSDIDRMYESLKEAANPMIHIVLGSSNVHITKKFNKNPEDILQMG 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + V A+ YT VE+S EDA R+ + + R +EA + AGAT +NIPDTVG+ +P F G Sbjct: 122 VDAVTYAKRYTSQVEYSLEDASRSDLEYMWRTIEAVVKAGATCVNIPDTVGFAVPELFGG 181 Query: 183 IISGLYERVPNI-DKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 +I +Y+R+ N+ ++SVH H+D GLA N+LAAV GA +VE +NGIGERAGN SL Sbjct: 182 LIHQIYDRLQNVAPHVLLSVHCHNDSGLATANTLAAVRNGANKVECTINGIGERAGNTSL 241 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EEV+M IK+ + + +T INH I+ TS++VS+ + + NKA+VG AFAHSSGIHQ Sbjct: 242 EEVVMGIKLHPEYYDGYTDINHSAIYETSRIVSRTMGLDVQVNKALVGENAFAHSSGIHQ 301 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 DG+LK++E YEI P IG + + LT+RSG+ A ++ ++GY+ + L+ ++ FL Sbjct: 302 DGLLKSKEVYEIFEPSDIGAPPMDIVLTARSGKHAFEYISKKLGYEIAPEVLNEIHANFL 361 Query: 362 KLADKKGQVFDYDLEALAFIG----KQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEE 417 K+AD+K +V+D D+ L G ++ E + + L+ F + N + +A VKL ++ Sbjct: 362 KIADEKKEVYDNDVIDL-LDGDERVQKNGEKKLWMLEDFQINVNMN-LPSATVKLVRNKQ 419 Query: 418 VKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHG 477 + GNG + A+Y AI + + + L+ Y + G K++LG+V + YNG+ + G Sbjct: 420 EAVVSEAGNGAISALYAAILKAVDMPIHLIDYRIQNIGAEKESLGKVVVQIQYNGKFYFG 479 Query: 478 VGLATDIVESSAKAMVHVLNNI 499 + D++++SA A+V+ +N I Sbjct: 480 KAIERDVMKASALALVNSVNKI 501 >UniRef50_C6CVJ5 2-isopropylmalate synthase n=2 Tax=Bacillales RepID=C6CVJ5_PAESJ Length = 513 Score = 379 bits (973), Expect = e-103, Method: Compositional matrix adjust. Identities = 199/486 (40%), Positives = 306/486 (62%), Gaps = 5/486 (1%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ IFDTTLRDGEQ+ AS+ + K+ IA L ++GVD++E GF +SSPG+F ++Q I+ Sbjct: 2 KKIQIFDTTLRDGEQSPGASIEPERKIIIARQLAKLGVDIIEPGFAISSPGEFAAIQQIS 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 R+++N +C AR V+ DID A ++ + A R+H FI++S +H++ ++R T EV++ A Sbjct: 62 RELQNVEICGFARAVKVDIDAAVKATQDAAKRRLHLFISSSDIHLSHQIRKTRSEVVQIA 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 M+ A+ + D+++F+ D+ R+ + +VEAAI +GAT IN+PDT+GY +P E Sbjct: 122 RDMISYAKQFVDEIQFAAMDSTRSDRDFVIELVEAAIESGATIINLPDTLGYALPNEMVD 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + + + ++ DK S H H+DLG+AV NSLAAV AGA QVE +NG+GERAGNCSLE Sbjct: 182 LFTSVRQQARGGDKVRYSTHNHNDLGMAVANSLAAVQAGATQVEVTVNGVGERAGNCSLE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E+ M I+ RK L + T I EI+ TS +VS+ + PI NK IVG AF H SGIHQD Sbjct: 242 ELAMLIETRKSALEIETNIEQSEIYTTSHMVSRAMHYPIAYNKPIVGRNAFQHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G+LK+R YEIM PE++G+++ + L SGR A+KHR+ E G ++ L+++YD F + Sbjct: 302 GLLKDRSTYEIMDPEAMGISRSMIILGRHSGRHAIKHRLSEYGIAVADNELNDVYDKFKQ 361 Query: 363 LADKKGQVFDYDLEALAFIGKQQE-EPEHFRLDYFSVQSGSNDIATAAVKLACGEE--VK 419 +AD+K V D +L +A G+ E +P+ ++L V +GS A+V + GE+ + Sbjct: 362 VADEKKIVTDDELIRIA--GEATETQPDPYKLMDLQVLAGSQKSRIASVTIRDGEDGGER 419 Query: 420 AEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVG 479 + + G GP++AV I + + L + G+DA G+ + G RF G Sbjct: 420 SYSGMGEGPLEAVIHCIQQAIPVAAQFEDLELHSLSTGEDAHGEAVVSIVIEGERFRGTS 479 Query: 480 LATDIV 485 + DI+ Sbjct: 480 IHKDII 485 >UniRef50_Q9LPR4 2-isopropylmalate synthase 1, chloroplastic n=39 Tax=cellular organisms RepID=LEU11_ARATH Length = 675 Score = 368 bits (945), Expect = e-100, Method: Compositional matrix adjust. Identities = 231/569 (40%), Positives = 326/569 (57%), Gaps = 76/569 (13%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V +FDTTLRDGEQ+ A+L+ KEKL IA L ++GVD++E GFP +S DFE+V+TIA Sbjct: 89 VRVFDTTLRDGEQSPGATLTSKEKLDIARQLAKLGVDIIEAGFPAASKDDFEAVKTIAET 148 Query: 65 VKNSR--------VCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 V N+ +C L+RC +KDI+ A +++K A+ RIHTFIATS +H+ KL+ T Sbjct: 149 VGNTVDENGYVPVICGLSRCNKKDIERAWDAVKYAKRPRIHTFIATSDIHLEYKLKKTKA 208 Query: 117 EVIERAIYMVKRARNY-TDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYT 175 EVIE A MV+ AR+ +DVEFS EDAGR+ L ++ I AGATT+NIPDTVG T Sbjct: 209 EVIEIARSMVRFARSLGCEDVEFSPEDAGRSEREYLYEILGEVIKAGATTLNIPDTVGIT 268 Query: 176 MPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGER 235 +P EF +I+ L P I+ +IS H +DLGL+ N+L+ HAGARQ+E +NGIGER Sbjct: 269 LPSEFGQLITDLKANTPGIENVVISTHCQNDLGLSTANTLSGAHAGARQMEVTINGIGER 328 Query: 236 AGNCSLEEVIMAIKVRKD--ILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAF 293 AGN SLEEV+MAIK R D + + T I+ + I TS++V + M +KAIVG+ AF Sbjct: 329 AGNASLEEVVMAIKCRGDHVLGGLFTGIDTRHIVMTSKMVEEYTGMQTQPHKAIVGANAF 388 Query: 294 AHSSGIHQDGVLKNRENYEIMTPESIGL---NQIQLNLTSRSGRAAVKHRMDE------- 343 AH SGIHQDG+LK++ YEI+ PE IGL N + L SGR A+K R+ E Sbjct: 389 AHESGIHQDGMLKHKGTYEIICPEEIGLERSNDAGIVLGKLSGRHALKDRLTEVHSNLTH 448 Query: 344 ----------------------MGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFI 381 +GY+ + L ++ F +A++K +V D D+ +A + Sbjct: 449 TNTCIAIFVGDTNVLLSFVHFQLGYQLDDEQLSTIFWRFKTVAEQKKRVTDADI--IALV 506 Query: 382 GKQQEEPEH-FRLDYFSVQSGSNDIATAAVKLACGEEVKAEAAN-GNGPVDAVYQAIN-- 437 + +PE ++L + G+ ++TA VKLA + + A + G GPVD+ Y+A++ Sbjct: 507 SDEVFQPEAVWKLLDIQITCGTLGLSTATVKLADADGKEHVACSIGTGPVDSAYKAVDLI 566 Query: 438 --------RITEYN-----VELVKYSLTAKGHGKDALGQVDIVA----NYNG-------- 472 R++ N L++YS+ A G DA+ ++ Y+ Sbjct: 567 VKVLFIPLRLSSTNNSPEPATLLEYSMNAVTEGIDAIATTRVLIRGSNKYSSTNAITGEE 626 Query: 473 --RRFHGVGLATDIVESSAKAMVHVLNNI 499 R F G G DIV SS KA V LN + Sbjct: 627 VQRTFSGTGAGMDIVVSSVKAYVGALNKM 655 >UniRef50_Q0AT07 2-isopropylmalate synthase n=3 Tax=Alphaproteobacteria RepID=Q0AT07_MARMM Length = 529 Score = 359 bits (921), Expect = 1e-97, Method: Compositional matrix adjust. Identities = 202/508 (39%), Positives = 293/508 (57%), Gaps = 33/508 (6%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 IFDTTLRDGEQA S++ EKL+IA LE M VD +E GF +SPGD E+++ IA +++ Sbjct: 19 IFDTTLRDGEQAPGFSMNPAEKLEIARLLEAMRVDTIEAGFAAASPGDSEAIRLIASEIR 78 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 NS +C+LAR E DID AA++L+ A R+H F+ATSP+H KLR + EV++ + Sbjct: 79 NSTLCSLARATEGDIDAAAKALEPAHRKRLHIFLATSPIHREAKLRMSRREVLQTIERCL 138 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 K A D++EFS EDA RT L + A GA +N+PDTVGY+ P E + Sbjct: 139 KHAAGTFDEIEFSAEDALRTEPDFLVEAMSCAAVNGADVLNVPDTVGYSEPDEIRAVFER 198 Query: 187 LYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIM 246 L V D I S H H+DLGLAV NSLAAV GARQVE A+NGIGERAGNCSLEE++M Sbjct: 199 LAAHVERPDHVIFSAHCHNDLGLAVSNSLAAVKGGARQVECAINGIGERAGNCSLEEIVM 258 Query: 247 AIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLK 306 A++VR DI + ++ +IW SQ ++++ + NKAIVG AFAH +GIHQ G++ Sbjct: 259 ALQVRADIFPAISHVDATKIWSASQRLARVTGSAVAPNKAIVGKNAFAHEAGIHQHGMIS 318 Query: 307 NRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADK 366 +R YEIMTPES+G L L SG+ A+ R+ ++GY+ L+ ++ F LAD+ Sbjct: 319 DRRTYEIMTPESVGAPGSALVLGKHSGKHALVQRLAKLGYQPDPDKLNQVFKDFKHLADE 378 Query: 367 KGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVK------- 419 G+V D DL A+ ++ FS + ++ G + K Sbjct: 379 LGEVNDADLVAM--------------MEGFSASGSRWTVLRTELRTTAGRQPKQFARVEL 424 Query: 420 --------AEAANGNGPVDAVYQAINRI--TEYNVELVKYSLTAKGHGKDALGQVDIVAN 469 ++ A+G+GP+ A + A+ RI T+ V ++ + + G++ + DI + Sbjct: 425 EHPDRGRVSDIASGDGPIAAAFAAVQRITGTDATVTALETRMRSTATGREFVA--DISID 482 Query: 470 YNGRRFHGVGLATDIVESSAKAMVHVLN 497 +G F G DIV ++ +++ L+ Sbjct: 483 IDGTIFSGRARGPDIVTAAIDSLLFTLD 510 >UniRef50_D2MJY3 2-isopropylmalate synthase n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MJY3_9BACT Length = 405 Score = 353 bits (905), Expect = 1e-95, Method: Compositional matrix adjust. Identities = 186/394 (47%), Positives = 260/394 (65%), Gaps = 7/394 (1%) Query: 112 RSTLDEVIERAIYMVKRARNYTDD-----VEFSCEDAGRTPIADLARVVEAAINAGATTI 166 R+T ++ + A V A++ +D VEFS DAGRT +A L VVEA I AGAT + Sbjct: 6 RTTPEDTLRMATAAVAYAKSLCEDHPDANVEFSPMDAGRTELAFLYEVVEATIAAGATVV 65 Query: 167 NIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVE 226 NIP+TVG+T+P EF +I + E VPN+D AIISVH H+DLGLAV NSL A+ GARQVE Sbjct: 66 NIPETVGWTVPTEFGNLIKSIMENVPNVDDAIISVHCHNDLGLAVANSLIAIEQGARQVE 125 Query: 227 GAMNGIGERAGNCSLEEVIMAIKVRKDIL-NVHTAINHQEIWRTSQLVSQICNMPIPANK 285 +NG+GERAGN SLEEV+MAI+ R+D N +T IN +EI S+ VS+ + + NK Sbjct: 126 CTINGLGERAGNTSLEEVVMAIRTRRDYFKNYYTEINAKEIVPISRRVSRTMGIAVQPNK 185 Query: 286 AIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMG 345 AIVG+ AFAHSSGIHQDG++K+R +EI+ P+ IG + QL L+ RSGR A++HR+ E+G Sbjct: 186 AIVGANAFAHSSGIHQDGIIKSRVTFEIIDPQEIGWKESQLILSPRSGRNALRHRLSELG 245 Query: 346 YKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDI 405 Y+ LD +Y+ FLK+ADKK + D DLEA+ + + P F LDY V SG+ Sbjct: 246 YEVEGAQLDKVYERFLKVADKKKSIQDADLEAI-MSDEIRAIPAIFELDYIQVVSGTKIS 304 Query: 406 ATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVD 465 T V + + V +A+ G+GPVDA ++AI ++ + + LV Y + + G+DA+G+V Sbjct: 305 PTTTVGIRTEDGVVEKASTGDGPVDAAFKAIAQVVDIQLNLVDYQIRSVTEGEDAIGEVS 364 Query: 466 IVANYNGRRFHGVGLATDIVESSAKAMVHVLNNI 499 + NG G G +TDI+E+SA+A +H +N + Sbjct: 365 LKVQDNGHIITGHGASTDIIEASARAYIHAVNKL 398 >UniRef50_C5SF21 Pyruvate carboxyltransferase n=1 Tax=Asticcacaulis excentricus CB 48 RepID=C5SF21_9CAUL Length = 527 Score = 349 bits (895), Expect = 2e-94, Method: Compositional matrix adjust. Identities = 206/492 (41%), Positives = 289/492 (58%), Gaps = 8/492 (1%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 +VI+FDTTLRDGEQA SL VK+KL +A L+ +GVDV+E GF SSPGD E+++TIAR Sbjct: 11 RVIVFDTTLRDGEQAPGFSLGVKDKLMLAHTLKDLGVDVIEAGFAASSPGDEEAIRTIAR 70 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 +V C+L+R +E DID AA +L A+ R H F+ATSP+H A KL+ T ++V+E A Sbjct: 71 EVVGPTFCSLSRALESDIDAAARALLPAKRKRCHIFLATSPIHRAAKLKKTREQVVEIAH 130 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 V A D+VEFS EDA RT L V AA AGA T+NIPDTVGYT P E I Sbjct: 131 KAVSYASTIFDEVEFSPEDAIRTEQDFLHEVCIAAAEAGARTLNIPDTVGYTTPKEIYQI 190 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 S L + + + I+S H HDDLGL V N+LAA+ AGARQ+E +NGIGERAGN +LEE Sbjct: 191 FSDLKAALKDHPQVILSAHNHDDLGLGVANTLAALEAGARQIEVTINGIGERAGNAALEE 250 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 V+MA++ R ++ +HT IN + + S L+S+ + NKA+VG AFAH SGIHQ G Sbjct: 251 VVMALRTRPELFKLHTGINTPLLSKASHLLSRATGTIVMRNKAVVGRNAFAHESGIHQHG 310 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 +L + YEIM PE +G + L L SGR A+ + +G+ E +L +L+ AF + Sbjct: 311 MLTDARTYEIMRPEDVGAEKSNLVLGKHSGRHAIAKQAAALGFDLDELSLGDLFAAFKRR 370 Query: 364 ADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSG-SNDIATAAVKLA--CGEEVKA 420 AD+ G++ +++L ++ + + + + RL F V S + D T + L GE +K Sbjct: 371 ADEIGEIDEFEL--MSLLTRDNADKDDARL--FKVSSEVTKDFVTITLDLFRDNGEPLKV 426 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 A G +A ++A+ + + + G D +I G + G G Sbjct: 427 -TATGLNAFEAGFRALVDAYQIEARVNDCEIIQSGFTFDGGAFAEISLQIKGEAYRGRGR 485 Query: 481 ATDIVESSAKAM 492 D V + +AM Sbjct: 486 GPDPVWAGLRAM 497 >UniRef50_O27525 2-isopropylmalate synthase 2 n=22 Tax=Archaea RepID=LEU12_METTH Length = 505 Score = 347 bits (890), Expect = 6e-94, Method: Compositional matrix adjust. Identities = 209/506 (41%), Positives = 300/506 (59%), Gaps = 21/506 (4%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + + V IFDTTLRDGEQ +L+V+EK IA L+ +GVD +E GFP +SPG+ S++ Sbjct: 12 LPENVRIFDTTLRDGEQTPGVALTVEEKTGIARKLDALGVDTIEAGFPAASPGEMNSIRR 71 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I + +C LAR + +DID A + IHTFI TSP+H KL+ + DE+I+ Sbjct: 72 IVELGLEANICGLARVLREDIDAAID----CGVDYIHTFIGTSPLHREYKLKMSPDEIID 127 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 RA++ V+ A + VEFS EDA RT L V AA +AGA IN+PDTVG +P Sbjct: 128 RAVFGVEYAAEHGLKVEFSAEDATRTEFDYLVEVYRAAEDAGAEIINVPDTVGVMIPRAM 187 Query: 181 AGIISGLYE--RVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGN 238 ++S L E RVP ISVH H+D GLAV NSLAAV AGA QV +NG+GERAGN Sbjct: 188 NHLVSRLKEELRVP------ISVHCHNDFGLAVANSLAAVEAGASQVHATVNGLGERAGN 241 Query: 239 CSLEEVIMAIKVRKDI-LNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 +LEEV+MA+ R D+ +++ T E+ S+ VS+I + +P NKAIVG AFAH + Sbjct: 242 AALEEVVMALITRYDLPVDIRTV----ELVNISEFVSKITGVRMPPNKAIVGENAFAHEA 297 Query: 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 GIH GVL+ E YE +TPE +G ++ ++ L +G A++ ++ E G + E LY Sbjct: 298 GIHVHGVLEKAETYEPITPEMVG-HKRRIVLGKHTGANALRSKLQEYGIEMKEEQFCTLY 356 Query: 358 DAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEE 417 + +L DK ++ D DL A+A + E +L+ +V +G + + TA VKL G+E Sbjct: 357 EQVKRLGDKGKRITDADLRAMAVTILGKASREIVKLEGIAVMTGESVMPTATVKLRIGDE 416 Query: 418 VKAEAANGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKDALGQVDIV-ANYNGRR 474 VK + G GPVDA AI + ++EL +Y++ A G +AL +V +V ++ G + Sbjct: 417 VKTTSMTGVGPVDAAINAIQSLVSETADIELDEYNIEAITGGTNALAEVFVVMSDGEGNK 476 Query: 475 FHGVGLATDIVESSAKAMVHVLNNIW 500 G DIV +S +A++ +N I Sbjct: 477 ATGRSTREDIVMASVEAVLDAINKIL 502 >UniRef50_C6PDK4 Pyruvate carboxyltransferase n=1 Tax=Thermoanaerobacterium thermosaccharolyticum DSM 571 RepID=C6PDK4_CLOTS Length = 397 Score = 334 bits (856), Expect = 6e-90, Method: Compositional matrix adjust. Identities = 173/376 (46%), Positives = 245/376 (65%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 ++VI+FDTTLRDGEQ + K +IA L +GVDV+E GFP +S G+FE+V+ IA Sbjct: 4 RKVIVFDTTLRDGEQTPGVNFDKDSKYRIAKQLVSLGVDVIEAGFPAASNGNFEAVKHIA 63 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 + + V L+RCV+ DID E+LK A+ RIH FIATS +H+ KL+ + DE ++ A Sbjct: 64 ENIDDVVVAGLSRCVKSDIDKTYEALKNAKKSRIHLFIATSDIHLKYKLKISRDEALKMA 123 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + VK A D+++FS EDA RT L ++ ++AGA INIPDTVGY +P EF Sbjct: 124 VDSVKYASGKFDEIQFSAEDASRTDWDFLVKIFNEVVDAGAKIINIPDTVGYAVPKEFEK 183 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 ++ + + + + D ISVH H+DLG+AV NSL+A+ GA QVE + GIGERAGN SLE Sbjct: 184 LVEYVKKHIHDKDNVTISVHCHNDLGMAVVNSLSALENGADQVEVTVCGIGERAGNASLE 243 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EVIMAI RKD N+ +IN +EI+ T +LVS++ + + NKAIVGS AF H++GIHQ Sbjct: 244 EVIMAINTRKDYFNLLHSINTREIFSTCKLVSELSGIDLQPNKAIVGSNAFRHTAGIHQH 303 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 GV+ N+ YEIM PE IG+ +++ SGR A + ++ MGY+ S ++ + F Sbjct: 304 GVINNKATYEIMRPEDIGITTDHISMGKLSGRNAFELKLKNMGYELSRDEMNLAFKKFKD 363 Query: 363 LADKKGQVFDYDLEAL 378 +AD K V D +++A+ Sbjct: 364 VADNKKIVNDNEIKAI 379 >UniRef50_Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic n=19 Tax=Brassicaceae RepID=MAM3_ARATH Length = 503 Score = 325 bits (834), Expect = 2e-87, Method: Compositional matrix adjust. Identities = 168/395 (42%), Positives = 255/395 (64%), Gaps = 15/395 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V + DTTLRDGEQ+ A+L+ +KL+IA L ++ VD+MEVGFPVSS +FE+++TIA+ Sbjct: 85 VRVLDTTLRDGEQSPGAALTPPQKLEIARQLAKLRVDIMEVGFPVSSEEEFEAIKTIAKT 144 Query: 65 VKN---------SRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 V N +C +ARC ++DI+ E+LK A+ R+ F +TS +H+ KL+ T Sbjct: 145 VGNEVDEETGYVPVICGIARCKKRDIEATWEALKYAKRPRVMLFTSTSEIHMKYKLKKTK 204 Query: 116 DEVIERAIYMVKRARNYT-DDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGY 174 +EVIE A+ VK A++ D++F CED GRT + +++ +I AGATT+ DTVG Sbjct: 205 EEVIEMAVNSVKYAKSLGFKDIQFGCEDGGRTEKDFICKILGESIKAGATTVGFADTVGI 264 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 MP EF +++ + E P D + ++H H+DLG+A N+++ + AGARQVE +NGIGE Sbjct: 265 NMPQEFGELVAYVIENTPGADDIVFAIHCHNDLGVATANTISGICAGARQVEVTINGIGE 324 Query: 235 RAGNCSLEEVIMAIKVRKDIL--NVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 R+GN LEEV+MA+K R + L V+T I+ ++I TS++V + M + +K IVG Sbjct: 325 RSGNAPLEEVVMALKCRGESLMDGVYTKIDSRQIMATSKMVQEHTGMYVQPHKPIVGDNC 384 Query: 293 FAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQ---LNLTSRSGRAAVKHRMDEMGYKES 349 F H SGIHQDG+LKNR YEI++PE +G+ + + + L SGR AVK R+ E+GY+ S Sbjct: 385 FVHESGIHQDGILKNRSTYEILSPEDVGIVKSENSGIVLGKLSGRHAVKDRLKELGYEIS 444 Query: 350 EYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQ 384 + ++++ + +L K ++ D DL+AL G + Sbjct: 445 DEKFNDIFSRYRELTKDKKRITDADLKALVVNGAE 479 >UniRef50_UPI0001C41E20 2-isopropylmalate synthase LeuA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41E20 Length = 511 Score = 308 bits (790), Expect = 3e-82, Method: Compositional matrix adjust. Identities = 182/507 (35%), Positives = 289/507 (57%), Gaps = 15/507 (2%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + ++ IFDTTLRDGEQA +L+V EK++IA L+ +GV+V+E+GFP S G+ ++ + Sbjct: 15 IPDEIKIFDTTLRDGEQAPGIALTVDEKIKIAQRLDELGVNVIEMGFPTVSSGERKAARE 74 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 + +S +C LAR V+KDID +S + H FI TSP+H KL+ + E++ Sbjct: 75 MVSLGFSSELCGLARVVQKDIDALIDS----DLSYAHLFIGTSPLHRDYKLKKSKTEILS 130 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 +++ MV+ A+++ VEFS EDA RT + L + +AGA IN+PDTVG +P Sbjct: 131 QSMEMVEYAKDHGLKVEFSAEDATRTELNYLIEFYKGVESAGADIINVPDTVGILVPSTT 190 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 +I L +++ IS+H H+D GLAV NSL + GA Q +NGIGERAGN S Sbjct: 191 RTLIRTLRKKI----NLPISLHFHNDFGLAVSNSLIGIEEGANQAHCTINGIGERAGNTS 246 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEE+++++K+ + ++ +++ TS + I + +P K IVG AFAH SGIH Sbjct: 247 LEELVVSLKIA---YGANLTVDTTKLYDTSNFIGSITGIKMPPTKPIVGDNAFAHESGIH 303 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 DG+LKN YE + PE +G ++ ++ L +G AA+K +++E + ++ DN+Y+ Sbjct: 304 VDGILKNSSTYEPIAPEIVG-HKRRIALGKHTGHAAIKSKLEEFNIEVTQKQFDNIYNQV 362 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 L DK + D DL ++A E+ +L SV +G + ATA +KL+ ++ Sbjct: 363 KTLGDKGKCLTDDDLRSIAITEIGTSGKEYIKLLGLSVMTGESVSATATIKLSIDGKIME 422 Query: 421 EAANGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKDALGQVDIV-ANYNGRRFHG 477 + G GPVDA A+ + + N+ L +Y L A G DAL + +V ++ G + G Sbjct: 423 TSQIGVGPVDASVLALKTLVQDRVNISLDEYRLEAITGGTDALAETFVVISDDKGNKATG 482 Query: 478 VGLATDIVESSAKAMVHVLNNIWRAAE 504 D++ SS A+++ +N I E Sbjct: 483 RATREDVILSSVIAVINSINRILDIQE 509 >UniRef50_B1MVR2 2-isopropylmalate synthase n=1 Tax=Leuconostoc citreum KM20 RepID=B1MVR2_LEUCK Length = 398 Score = 308 bits (789), Expect = 3e-82, Method: Compositional matrix adjust. Identities = 158/378 (41%), Positives = 232/378 (61%), Gaps = 1/378 (0%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+ Q+ +D T+RDGEQ + + ++ EK+++A ALE+ GV +E GFP +S DF++V Sbjct: 7 MTNQITFYDPTMRDGEQTIGVNFTIDEKIKLAQALEKYGVSAIEAGFPAASKKDFDAVVE 66 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I++ V ++V LAR V +DID + + A+ IH FIATSP+H KL + E+IE Sbjct: 67 ISKVVHTAKVVGLARLVRQDIDAVVAATQQAKHPMIHVFIATSPVHRTYKLHMSPSEIIE 126 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 + I ++ + ++ FS EDA RT LARV++AAI +GAT INIPDTVGY P+E+ Sbjct: 127 KVISDIRYTKTMMSEIIFSPEDATRTEPEFLARVIQAAIESGATMINIPDTVGYATPYEY 186 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 + L E V + D+ + HTH+DLG+A N+LA + GA +++G +NGIGERAGN Sbjct: 187 GELFEYLREHVRDFDQVTWATHTHNDLGMANANALAGIMHGATEIQGTINGIGERAGNVD 246 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 + E AI VR+ TAI ++ S +V+Q +MP+ NK I+G AFAH SGIH Sbjct: 247 IIEAAAAIYVRRQTFAKQTAIILEQSKHISDIVAQATHMPVAKNKPIMGRNAFAHESGIH 306 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 QDG LKN E YEI+ PE +G Q L L SG AV +++ +GY S ++ + F Sbjct: 307 QDGYLKNPETYEILRPEMVG-TQASLPLGKLSGSHAVMNQLLSLGYHISRQDMVTILPIF 365 Query: 361 LKLADKKGQVFDYDLEAL 378 ++A+K V D ++ + Sbjct: 366 KRIAEKTSTVSDQQMQDM 383 >UniRef50_D2RHN2 Isopropylmalate/citramalate/homocitratesynthase n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RHN2_ARCPR Length = 498 Score = 301 bits (772), Expect = 3e-80, Method: Compositional matrix adjust. Identities = 185/501 (36%), Positives = 282/501 (56%), Gaps = 22/501 (4%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 +FDTTLRDGEQ SL V K+QIA L+++GVDV+E GFP +S G+FE+V+ IA Sbjct: 6 VFDTTLRDGEQMPGVSLPVNYKIQIAKQLDKLGVDVIEAGFPSASKGEFEAVKEIANLGL 65 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 N+++C LAR V+KDID A + A+ +H FI TS + + ++ T DE+++ ++ V Sbjct: 66 NAKICGLARVVKKDIDQAIK----ADVDIVHVFIPTSKIQVEHTIKKTPDEIVQLSVDAV 121 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 + +++ + FS DA RT + L R+ +A AG IN+PDTVG PF F +I Sbjct: 122 EYVKSHGVECMFSAMDATRTEMDFLKRIYKAVEEAGVDIINVPDTVGIATPFRFYDMIKK 181 Query: 187 LYER--VPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 L E VP I VH H+D GLA N+ AAV AGA +V+ +NG+GERAGN LEEV Sbjct: 182 LKEHLNVP------IDVHCHNDFGLATANTYAAVLAGADEVQVTVNGLGERAGNAPLEEV 235 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 + + T I + + TS+LV ++ + +P NK IVG AF+H SGIH GV Sbjct: 236 VALLYAE----GFKTNIRMEYLVETSRLVERLTGVKMPPNKPIVGENAFSHESGIHAHGV 291 Query: 305 LKNRENYE--IMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 LK+ +E I+TPE +G ++ ++ + +GR +K +++ GY + L + + Sbjct: 292 LKDARTFEPGIITPEMVG-HKRRIVVGKHAGRHQIKKILEDAGYVVDDEKLSIIVQKVKE 350 Query: 363 LADKKGQVFDYDLEALA--FIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 L DK +V D DL A+A +G+ E+ +D +V +G+ TA + E K Sbjct: 351 LGDKGKKVTDLDLFAIAESVLGEVSEKDRIINVDEVTVLTGNKITPTAVINAEVEGERKV 410 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDI-VANYNGRRFHGVG 479 +A G GPVDA ++A+ + +++ ++ L A G DAL V + V + +G F Sbjct: 411 TSAIGVGPVDATFKAVTELLGRKIKITEFRLDAITGGSDALANVYVTVEDEDGETFTARS 470 Query: 480 LATDIVESSAKAMVHVLNNIW 500 DIV +S A++ +N + Sbjct: 471 AGADIVMASFDAVIKAVNYLM 491 >UniRef50_P58968 2-isopropylmalate synthase 2 n=19 Tax=Archaea RepID=LEU12_METMA Length = 516 Score = 298 bits (764), Expect = 3e-79, Method: Compositional matrix adjust. Identities = 196/511 (38%), Positives = 288/511 (56%), Gaps = 27/511 (5%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 S++V +FDTTLRDGEQ SL+ +KL+IA L+++GVD++E GFP+SS GD ESV++I Sbjct: 17 SKKVTVFDTTLRDGEQTPGVSLTSTQKLEIAHQLDKLGVDIIEAGFPISSEGDKESVKSI 76 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 + ++ VC LAR ++KDID ES + +HTF+ TS + ++ + +EVI+ Sbjct: 77 SNAGLDTTVCGLARVLKKDIDACFES----DVGLVHTFVPTSDVQRIYTIKKSREEVIQL 132 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 A+ V+ +++ FS DA RT L V +A AG IN+PDTVG +P Sbjct: 133 AVEAVQYIKDHGLKCMFSAMDATRTDPEYLIEVFKAVQEAGCDIINVPDTVGVMVP---- 188 Query: 182 GIISGLYERVPNIDKAI---ISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGN 238 S +Y ++ I I I VH H+D GLAV NSL AV AGA QV+ +NGIGERAGN Sbjct: 189 ---SAMYRQIKGIAAEITIPIDVHCHNDFGLAVANSLMAVEAGASQVQVTINGIGERAGN 245 Query: 239 CSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSG 298 L + +M++ I T I + + TS++V + +P N +VG AF+H SG Sbjct: 246 ADLSQTVMSL---TSIYGAKTNIRTEYLVETSKMVENYTGIRLPPNTPVVGQNAFSHESG 302 Query: 299 IHQDGVLKNRENYE--IMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNL 356 IH GVL+ + +E IMTPE +G ++ ++ L +G+ AVK ++ G K ++ LD + Sbjct: 303 IHSQGVLEKSDTFEPGIMTPEMVG-HRRRIVLGKHTGKHAVKQSLESAGIKTNDNQLDEI 361 Query: 357 YDAFLKLADKKGQVFDYDLEAL--AFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLAC 414 ++A+K Q+ D DL A+ A +GK E E +L SV +G+ TA VK Sbjct: 362 VIRIKEIANKGKQITDADLYAVASAVLGKASSEEELIKLKEVSVMTGNILTPTAVVKADI 421 Query: 415 -GEEVKAEAANGNGPVDAVYQAINRIT-EYN-VELVKYSLTAKGHGKDALGQVDI-VANY 470 G+E+ A A G GPVDA A+ I E N L + + A G DAL V I + N Sbjct: 422 EGKEIIA-ARTGVGPVDAALHAVRDILGESNHFRLQDFRIDAITGGADALADVYIGLENE 480 Query: 471 NGRRFHGVGLATDIVESSAKAMVHVLNNIWR 501 GR DIV +S +A+V+ +N +++ Sbjct: 481 KGRIVTARSANPDIVMASVEALVNAMNLLYK 511 >UniRef50_Q58787 (R)-citramalate synthase n=5 Tax=Methanococcales RepID=CIMA_METJA Length = 491 Score = 298 bits (764), Expect = 3e-79, Method: Compositional matrix adjust. Identities = 189/501 (37%), Positives = 287/501 (57%), Gaps = 22/501 (4%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 IFDTTLRDGEQ SL+ +KL+IA L+ +GVDV+E G ++S G+ E ++ I ++ Sbjct: 5 IFDTTLRDGEQTPGVSLTPNDKLEIAKKLDELGVDVIEAGSAITSKGEREGIKLITKEGL 64 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 N+ +C+ R + DID A E + +H + TSP+H+ KLR T DEV+E A+ V Sbjct: 65 NAEICSFVRALPVDIDAALE----CDVDSVHLVVPTSPIHMKYKLRKTEDEVLETALKAV 120 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 + A+ + VE S EDA R+ + L ++ GA + + DTVG P + + Sbjct: 121 EYAKEHGLIVELSAEDATRSDVNFLIKLFNEGEKVGADRVCVCDTVGVLTPQKSQELFKK 180 Query: 187 LYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIM 246 + E V N+ +SVH H+D G+A N+ +AV GA Q +NGIGERAGN SLEEV+ Sbjct: 181 ITENV-NLP---VSVHCHNDFGMATANTCSAVLGGAVQCHVTVNGIGERAGNASLEEVVA 236 Query: 247 AIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLK 306 A+K+ + T I ++++ S++VS++ +P+P NKAIVG AFAH +GIH DG++K Sbjct: 237 ALKI---LYGYDTKIKMEKLYEVSRIVSRLMKLPVPPNKAIVGDNAFAHEAGIHVDGLIK 293 Query: 307 NRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADK 366 N E YE + PE +G N+ ++ L SGR A+K+++D MG S+ L+ +Y+ + D Sbjct: 294 NTETYEPIKPEMVG-NRRRIILGKHSGRKALKYKLDLMGINVSDEQLNKIYERVKEFGDL 352 Query: 367 KGQVFDYDLEALA--FIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLAC-GEEVKA-EA 422 + D DL A+ GK E E +LD +V SG+ A+VKL GE++ E Sbjct: 353 GKYISDADLLAIVREVTGKLVE--EKIKLDELTVVSGNKITPIASVKLHYKGEDITLIET 410 Query: 423 ANGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 A G GPVDA A+ + +++LV+Y + A G G DAL +V +V G V Sbjct: 411 AYGVGPVDAAINAVRKAISGVADIKLVEYRVEAIGGGTDALIEV-VVKLRKGTEIVEVRK 469 Query: 481 A-TDIVESSAKAMVHVLNNIW 500 + DI+ +S A++ +N + Sbjct: 470 SDADIIRASVDAVMEGINMLL 490 >UniRef50_A8HXS9 Isopropylmalate synthase (Fragment) n=1 Tax=Chlamydomonas reinhardtii RepID=A8HXS9_CHLRE Length = 444 Score = 298 bits (763), Expect = 3e-79, Method: Compositional matrix adjust. Identities = 176/449 (39%), Positives = 256/449 (57%), Gaps = 46/449 (10%) Query: 79 KDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNY-TDDVE 137 +D++ A ++++ A+ R+HTFIATS +H+ + + + A+ VK R+ D+E Sbjct: 1 QDLERAWDAVRHAKRPRVHTFIATSEIHMKVSQQGSATSGLHNAVAAVKHLRSLGCTDIE 60 Query: 138 FSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKA 197 FS EDAGR+ L R++ I AGATT+NIPDT G+ +P EF +I+ + + P D Sbjct: 61 FSSEDAGRSDPKFLYRILGEVIKAGATTLNIPDTTGWCLPHEFGELIAAIKKNTPGADNV 120 Query: 198 IISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNV 257 IIS H +DLGL+ NSLA AGARQ+E +NGIGERAGN SLEEV+MAIK+R Sbjct: 121 IISTHCQNDLGLSTANSLAGAQAGARQIECTINGIGERAGNASLEEVVMAIKLR------ 174 Query: 258 HTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPE 317 ++VS M + A+KAIVG+ AFAH SGIHQDG+LKNRE YEIM+PE Sbjct: 175 ------------GKMVSDYSGMVVQAHKAIVGANAFAHESGIHQDGMLKNRETYEIMSPE 222 Query: 318 SIGLNQIQLN----LTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDY 373 SIGL + + + L SGR A+ R+ +GY+ S+ LD+++ F LADKK + D Sbjct: 223 SIGLPRQEQDRGIVLGKHSGRNALNSRLRTLGYELSQSELDDVFKRFKALADKKKGITDE 282 Query: 374 DLEALAFIGKQQEEPEH-FRLDYFSVQSGSNDIATAAVKLACGEEV-KAEAANGNGPVDA 431 D+ LA + + +P+ + L V G+ + TA V++ + + + G GPVDA Sbjct: 283 DI--LALMSDELHQPKVIWELLDLQVVCGTMGMPTATVQMKGPDGIARIGVGVGTGPVDA 340 Query: 432 VYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNG-----------------RR 474 Y+A++ + EL YS+++ G +AL ++ +G R+ Sbjct: 341 AYKAVDSLVRVEAELSDYSVSSVTQGIEALAHTRVMIRPSGKMSDAGYSEHAALGTVQRQ 400 Query: 475 FHGVGLATDIVESSAKAMVHVLNNI--WR 501 F G G DIV +SA+A V LN + WR Sbjct: 401 FSGSGANEDIVVASARAYVSALNKMIGWR 429 >UniRef50_A8TGZ1 Isopropylmalate/citramalate/homocitrate synthase n=1 Tax=Methanococcus voltae A3 RepID=A8TGZ1_METVO Length = 574 Score = 286 bits (731), Expect = 2e-75, Method: Compositional matrix adjust. Identities = 182/522 (34%), Positives = 275/522 (52%), Gaps = 34/522 (6%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 IFDTTLRDGEQ + S +K KL+IA L+ +GV+ +E GFP++S G+FE+V+ I + Sbjct: 53 IFDTTLRDGEQTPEVSFPIKAKLEIASKLDELGVNTIEAGFPITSNGEFEAVKKIKQLDL 112 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 N+ +C L+RC KDID + + RIH FIATSP+H KL+ + ++++ + + Sbjct: 113 NATICGLSRCSNKDIDAVID----CDLDRIHLFIATSPLHREYKLKKSKEQILNKISESI 168 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 A+ + VEFS EDA RT + L RV + AI + I+IPDTVG P + +I Sbjct: 169 IYAKEHGLSVEFSAEDATRTELDYLIRVYKEAITSKVDYIDIPDTVGILTPKKMENLIKD 228 Query: 187 LYERV-------------------PNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEG 227 L + N+ ++SVH H+D GLAV NSL+A G Q+ Sbjct: 229 LKSGLETNKAINNSSTLTNQINIKSNMQMPVLSVHCHNDFGLAVANSLSAFEQGVSQIHC 288 Query: 228 AMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAI 287 +NGIGERAGN L E + ++K I I + + S+LV+ N+PI NK + Sbjct: 289 TVNGIGERAGNTDLAEFVSSLKFLCGIEPETLTIKTELLSDISKLVAHYTNIPIAPNKPL 348 Query: 288 VGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK 347 VG AFAH SGIH GV+ N YE ++P +G N+ +L L +G ++K ++ EMG Sbjct: 349 VGRNAFAHESGIHTHGVIANALTYEPISPFDVG-NKRRLVLGKHAGAHSIKLKLQEMGLN 407 Query: 348 E----SEYNLDNLYDAFLKLADKKGQVFDYDLEALA--FIGKQQEEPEHFRLDYFSVQSG 401 S + + D L DK V D DL A+ K + L+ +V +G Sbjct: 408 VGKNLSTEQFEEIVDKIKALGDKGKLVLDADLRAIIKDVTSKVIKSKRVVNLEQLAVITG 467 Query: 402 SNDIATAAVKL-ACGEEVKAEAANGNGPVDAVYQAINRITEYNV--ELVKYSLTAKGHGK 458 N I TA+V + G+ KA + G GPVDA +A+ + V +L++Y++ A G Sbjct: 468 INVIPTASVAVNIAGKRYKA-SEMGVGPVDASLKALESVVGETVKAKLIEYTINAATGGS 526 Query: 459 DALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIW 500 DA+ V + N + + D+V +S +A++ +N + Sbjct: 527 DAIADVVVKLENNKKIVTAKSTSEDVVHASVEAVIEGINRLL 568 >UniRef50_Q6T1C1 2-isopropylmalate synthase (Fragment) n=1 Tax=Xenorhabdus nematophila RepID=Q6T1C1_XENNE Length = 210 Score = 286 bits (731), Expect = 2e-75, Method: Compositional matrix adjust. Identities = 132/187 (70%), Positives = 159/187 (85%) Query: 330 SRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPE 389 SRSGRAAVKHRM EMGY+E++Y+LD LY AFLKLADKKGQVFDYDLEAL FI +QQ+E E Sbjct: 1 SRSGRAAVKHRMTEMGYQENDYDLDILYQAFLKLADKKGQVFDYDLEALVFINQQQQEYE 60 Query: 390 HFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKY 449 H+RLDYFS+QSG+N + TA V+LACG+E+ +EAA GNG VDA+YQAI RIT Y ++L+ Y Sbjct: 61 HYRLDYFSIQSGTNVVPTATVRLACGDEITSEAATGNGTVDAIYQAIGRITGYPLKLISY 120 Query: 450 SLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKEL 509 L+ KGHGKDALGQVDI+ GRRFHG+GL TDI+ESSA+AM+HVLNNIW+A +VEKE Sbjct: 121 QLSGKGHGKDALGQVDIIVECFGRRFHGMGLETDIIESSARAMIHVLNNIWQAEQVEKEK 180 Query: 510 QRKAQHN 516 QR + N Sbjct: 181 QRISHCN 187 >UniRef50_O26819 (R)-citramalate synthase n=20 Tax=Archaea RepID=CIMA_METTH Length = 496 Score = 285 bits (728), Expect = 4e-75, Method: Compositional matrix adjust. Identities = 185/499 (37%), Positives = 274/499 (54%), Gaps = 15/499 (3%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 QV + DTTLRDGEQ SL+ +EKL+IAL ++ +G D++E G ++S G+ E ++ I Sbjct: 2 QVRVLDTTLRDGEQTPGVSLTPEEKLRIALKIDALGADIIEAGSAITSEGEREGIRKITS 61 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 + + +C+ AR V +DID A + +H + TS +H+ KLR T +EV+E+A+ Sbjct: 62 EGLRAEICSFARAVREDIDAAIS----CDVDSVHLVVPTSDLHLEHKLRKTREEVLEQAV 117 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 + A ++ VE S ED+ R+ + L + I AGA I DTVG P Sbjct: 118 DCTEYAVDHGILVELSAEDSTRSDMDFLRTIFREGIEAGAERICACDTVGILTPERSYEF 177 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 GL E A +SVH H+D GLAV NSLA + AGA +V +NGIGERAGN +LEE Sbjct: 178 YRGLSEL-----GAPLSVHCHNDFGLAVANSLAGLRAGASEVHATINGIGERAGNAALEE 232 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 V++A+ K + +V T+IN + ++ TS++V+++ + + NKAIVG AFAH SGIH DG Sbjct: 233 VVVAL---KSLYDVDTSINIEMLYETSRMVARMTGVYLQPNKAIVGENAFAHESGIHADG 289 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 VLK E YE +TPE +G + + G A++ R+DE+G K ++ L ++ L Sbjct: 290 VLKKAETYEPITPEMVGHGR-GFVMGKHIGTHALRKRLDELGMKVADDKLMEIFRRVKTL 348 Query: 364 ADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAA 423 D V D DL+A+A E + L ++ SG+ TA+VKL + EA Sbjct: 349 GDMGKCVTDVDLQAIAEDVLGVMEDKVVDLQEVTIVSGNRVTPTASVKLRVDDREVLEAG 408 Query: 424 NGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLA 481 G GPVDA AI + E ++ L +Y + A G DAL V I + R Sbjct: 409 TGVGPVDAAIVAIKKSLEDFADITLEEYHVDAITGGTDALIDVVIKLRHGDRIISARSTQ 468 Query: 482 TDIVESSAKAMVHVLNNIW 500 DI+ +S +A + +N + Sbjct: 469 PDIIMASVEAFLSGVNRLL 487 >UniRef50_A8AB61 2-isopropylmalate synthase n=25 Tax=Archaea RepID=LEU1_IGNH4 Length = 399 Score = 276 bits (706), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 155/365 (42%), Positives = 221/365 (60%), Gaps = 11/365 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + ++V IFDTTLRDGEQ S + ++KL IA L ++GV +E GFP S G+FE+V+ Sbjct: 16 LPKEVRIFDTTLRDGEQTPGISFTKEQKLMIARQLAKLGVASIEAGFPAVSQGEFEAVKA 75 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 IAR+ + ALAR ++DID A + A+ IH FIA S +H+ KLR T +E + Sbjct: 76 IAREGLGPEIVALARANKRDIDKALD----ADVDAIHVFIAASDIHLKYKLRMTREEALR 131 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 RA+ V+ A+++ VEFS ED R + L +VEA ++AGA ++IPDTVG P Sbjct: 132 RAVEAVEYAKSHGVTVEFSPEDGTRADLNYLYTMVEAVVDAGADRVDIPDTVGVMTPTRM 191 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 +I + +P I+SVH H+D GLAV NS+A + AGARQ +NGIGERAGN + Sbjct: 192 KYLIKFI---LPAAKGRIVSVHCHNDFGLAVANSIAGIEAGARQAHVTVNGIGERAGNAA 248 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV+ A++ +LNV T +N + ++ TS LVS+I +PIP NK IVG F+H SGIH Sbjct: 249 LEEVVAALEF---LLNVRTGVNTKLLYETSLLVSKITGIPIPPNKPIVGENVFSHESGIH 305 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 GV+ N YE + PE +G + ++ L SGR V++ + +GY + + D Sbjct: 306 VHGVINNPFTYEPIQPEMVGQRR-RIVLGKHSGRHGVEYALKTLGYPTDPDVVLRVLDEV 364 Query: 361 LKLAD 365 +L D Sbjct: 365 KRLGD 369 >UniRef50_Q8KTR5 Alpha-isopropylmalate synthase n=14 Tax=Candidatus Tremblaya princeps RepID=Q8KTR5_TREPR Length = 390 Score = 276 bits (706), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 155/380 (40%), Positives = 222/380 (58%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + I DTTLRDGEQA + K ++A LE GVDV+E GF SS DFE+++ I+ Sbjct: 9 IAILDTTLRDGEQAPCIVMGPDAKAEMARRLEIAGVDVVEAGFAASSSSDFEAIRRISCC 68 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 V+ VC+LAR V D+ AA++L+ A RIH FI +S +HI KLR +V++RA Sbjct: 69 VRGCVVCSLARAVGHDVRKAAKALEFARHPRIHVFIGSSSLHIEEKLRMHPLDVVDRAAA 128 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 MV+ AR Y DDVEFS ED+ R + L + +AA+ AGAT +N+ DTVG+ +P + + + Sbjct: 129 MVRLARAYCDDVEFSPEDSSRADPSFLCSLAKAAVEAGATIVNVTDTVGHGIPEQLSDVA 188 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 L VP D+ +SVH H+D+GLA+ N++AA+ A Q E + GIGERAGN +LEEV Sbjct: 189 GMLCRSVPISDRVTLSVHCHNDVGLALANTMAAIACCAGQAECTVTGIGERAGNAALEEV 248 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 ++A + + ++ + + +QL S I +PA K +VG AFAH+SGIHQDGV Sbjct: 249 VVAAGLEYSGAGMDVRVDARHMRSIAQLASAIARRRLPATKPVVGCHAFAHASGIHQDGV 308 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 +KNR YE + E +G + L SG A+++R++ G + L LA Sbjct: 309 IKNRRTYEALRAEDVGGRGGSIVLGKLSGTHALRNRLEGGGVTIGAMGVPRLATMMKGLA 368 Query: 365 DKKGQVFDYDLEALAFIGKQ 384 V+D L AL I + Sbjct: 369 SHLPVVYDSALAALHAIASR 388 >UniRef50_UPI0001C42034 citramalate synthase CimA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C42034 Length = 497 Score = 270 bits (690), Expect = 1e-70, Method: Compositional matrix adjust. Identities = 175/506 (34%), Positives = 284/506 (56%), Gaps = 22/506 (4%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 ++ + DTTLRDGEQ SL+ +KL+IA L+ +GV+ +E G ++S G+ E+++ I Sbjct: 2 KIEVLDTTLRDGEQTPGISLNTIKKLRIATKLDEIGVNSIEAGSAITSEGEREAIKAITS 61 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 Q N+ + + +R + KD+D E + ++ + TS +H+ KL+ T DE++E A+ Sbjct: 62 QGLNAEIVSFSRTLIKDVDYCLE----CDVDAVNIVVPTSDLHLQYKLKKTQDEMLEDAV 117 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMP---FEF 180 + + A+++ VE + ED+ RT I L ++ +A I+AGA I DT+G P F F Sbjct: 118 KVTEYAKDHGVKVELAAEDSTRTDIQYLRKIFKATIDAGADRICPCDTLGILTPLKSFNF 177 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 + L VP +S H H+D GLAV N+L+A+ GA + +NG+GERAGN + Sbjct: 178 YKQFTDL--GVP------VSAHCHNDFGLAVANTLSAIDGGASRFHATINGLGERAGNAA 229 Query: 241 LEEVIMAI-KVRKDILN---VHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHS 296 LEEV++++ + KD N T I +I+ TS+LVS++ N + NK IVG AFAH Sbjct: 230 LEEVVVSLYTLYKDESNERKYETDIKIDQIYSTSKLVSRLSNAYLAPNKPIVGENAFAHE 289 Query: 297 SGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNL 356 SGIH DGV+KN YE + PE +G ++ + + G + +R++E+G + ++ L+++ Sbjct: 290 SGIHADGVIKNSATYEPIMPELVG-HRRKFVIGKHVGTKGLNNRLEELGLEVNKKQLNDI 348 Query: 357 YDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGE 416 + L DK V D DLEA+A E+ + LD ++ SG+ TA++KL Sbjct: 349 FYKVKDLGDKGKTVTDTDLEAIAEHVLNIEQEKKINLDELTIVSGNKIRPTASIKLNIEN 408 Query: 417 EVKAEAANGNGPVDAVYQAINR-ITEY-NVELVKYSLTAKGHGKDALGQVDIVANYNGRR 474 E EA G GPVDA A+N+ I + +++L +Y + A G DAL +V I + + Sbjct: 409 EEVIEADVGIGPVDAAINAVNKGIKSFADIQLEEYHVDAVTGGTDALIEVIIKLSSGDKI 468 Query: 475 FHGVGLATDIVESSAKAMVHVLNNIW 500 DI+ +S +A + +N + Sbjct: 469 ISARATEPDIINASVEAYIDGVNRLL 494 >UniRef50_A6VFV4 Isopropylmalate/citramalate/homocitrate synthase n=7 Tax=Methanococcales RepID=A6VFV4_METM7 Length = 492 Score = 270 bits (690), Expect = 1e-70, Method: Compositional matrix adjust. Identities = 180/504 (35%), Positives = 282/504 (55%), Gaps = 31/504 (6%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 IFDTTLRDGEQ SLS EKL+IA+ L+ +GV+++E G ++S G+ E+++ +A Q Sbjct: 4 IFDTTLRDGEQTPGVSLSPSEKLEIAIKLDELGVNIIEAGSAITSKGEREAIKLVAEQKL 63 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 N+ + + R + DID AA S V +H + TS +H+ KLR T +E ++ A++ V Sbjct: 64 NAEISSFVRALPVDID-AALSCNVDS---VHLVVPTSDLHMEYKLRKTREENLKDAMHAV 119 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 A+ + VE S EDA R+ + L + + A I + DTVG P + +I Sbjct: 120 DYAKEHGLIVELSAEDATRSDVEFLKELFKKGEELKADRICLCDTVGILTPVKSMELIKT 179 Query: 187 LYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIM 246 + V IS+H H+D G+A N+L+A+ AGA Q +NGIGERAGN SLEEV+M Sbjct: 180 MKAAVT----IPISIHCHNDFGMATANTLSAISAGADQCHVTINGIGERAGNASLEEVVM 235 Query: 247 AIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLK 306 ++ K + ++ T I +++++ S++VS+ + +PANKA+VG AFAH +GIH DG++K Sbjct: 236 SL---KSLYDMETNIQTEKLYKISRIVSKYMKLSVPANKALVGDNAFAHEAGIHVDGLMK 292 Query: 307 NRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADK 366 + E YE + PE +G N+ ++ L SG+AA+K++++ M S + +Y D Sbjct: 293 STETYEPIGPEVVG-NRRKIILGKHSGKAALKYKLELMNIGLSHEQFEEVYSKIKAFGDL 351 Query: 367 KGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGS--NDIATAAVKLACGEEVK---AE 421 + D DL+ + + E LD +V SG+ + +A+ +K A +K E Sbjct: 352 GKYISDVDLKTVISQVQGVELERKVILDEITVMSGNKVSPLASINLKFANDCNIKDNIRE 411 Query: 422 AANGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKDALGQVDIVANYNG------R 473 AA G GPVDA A+ + ++EL YS+ A G DAL +V +V G R Sbjct: 412 AAYGLGPVDAAINAVKKALTGVADIELEDYSVRAMTGGTDALIEV-VVHLRKGNEVVEVR 470 Query: 474 RFHGVGLATDIVESSAKAMVHVLN 497 + HG D+V +S +AM+ +N Sbjct: 471 KAHG-----DVVMASVEAMMDGIN 489 >UniRef50_C1ZKW9 Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZKW9_PLALI Length = 418 Score = 265 bits (678), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 149/351 (42%), Positives = 210/351 (59%), Gaps = 2/351 (0%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 S ++++ DTTLRDGEQ A+L +EK +IALALE G+ ++ GFP SS DF++++ + Sbjct: 26 SGRIMLSDTTLRDGEQMPGATLEPEEKREIALALEAAGIHSLDAGFPASSQQDFDAIRLM 85 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFR--IHTFIATSPMHIATKLRSTLDEVI 119 A+ +K + AL R VE D+D A E+L + + FI TSP+H KLR + EV+ Sbjct: 86 AQVIKRPVMTALCRTVEGDVDAADEALAGLAPHKRGVSLFIGTSPLHREYKLRKSRTEVL 145 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE 179 V+ A D V FS EDA RT L E AI AGATTI PDTVG P Sbjct: 146 SIIDRSVRYASKKFDIVAFSPEDASRTEADFLVECYETAIQAGATTIGYPDTVGVLTPER 205 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 I + E VP+I K +++VH H+DLGLAV NSLA + AGA V+ +NGIGERAGN Sbjct: 206 AYVAIRHVMEHVPSIRKVLVAVHMHNDLGLAVANSLAGLTAGAHIVQCTVNGIGERAGNA 265 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 +LEEV MA+ V ++ +N++ ++ QLV++ +P+ NK + G FA +GI Sbjct: 266 ALEEVAMALYVNQEQYGRAVKLNYESLFPLCQLVAKKTGVPMALNKPVAGRTIFATEAGI 325 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESE 350 HQDG+LK+ + Y PE +G I+L L SG+ AV H + +GY+ ++ Sbjct: 326 HQDGLLKHPDTYLPYRPEVVGGPAIELVLGRHSGKGAVAHHLQNLGYQATD 376 >UniRef50_Q18KM5 2-isopropylmalate synthase n=9 Tax=Euryarchaeota RepID=Q18KM5_HALWD Length = 531 Score = 254 bits (649), Expect = 5e-66, Method: Compositional matrix adjust. Identities = 175/497 (35%), Positives = 262/497 (52%), Gaps = 18/497 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V + DTTLRDGEQA SL EK +IA L+R G++ +E G + G+ E+++ + Sbjct: 23 VQLLDTTLRDGEQAPGISLDPDEKAEIARELDRSGIEFIEAGSACTGEGERETIRQVTGL 82 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 ++ V + AR V+ DI++A + + + S HI TK+ ST EV+ Sbjct: 83 DLDATVTSFARGVKSDIELAVD----CGVDGVTIVVPASDQHIETKVGSTRSEVVTTTAE 138 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 +V+ A+++ VE ED R I L R++ A++AGA DTVG+ P + Sbjct: 139 LVEYAKDHDLWVEVIGEDGSRADIEFLERLMREALDAGADRSCYADTVGHANPETTYEYV 198 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 S L P +S HTHDDLGLA+ N ++ AGA V G +NGIGERAGN +LEEV Sbjct: 199 SRLAALGP------VSTHTHDDLGLAMTNVWVSLAAGADLVHGTVNGIGERAGNVALEEV 252 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 +A+ DI TA Q ++ +Q VSQ N+P+P NKA++G AF H SGIH DG Sbjct: 253 AIALAHGYDI---ETATLDQ-LYSLAQTVSQATNIPLPPNKAVIGENAFTHESGIHTDGT 308 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 LK++ YE +P S+G + +L L +GRA V+ +DE SE + + D +L Sbjct: 309 LKDKTMYEPYSPSSVGRER-RLVLGKHAGRAGVQAALDEHRIDVSEDEVTAIVDRVKELG 367 Query: 365 DKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAAN 424 D+ +V D DL +A + +E H L + SG TA+++L GE + + Sbjct: 368 DRDKRVTDADLLTIAEEVQGRERDRHVELLDLTAASGGG-TPTASIRLRVGENERVASGT 426 Query: 425 GNGPVDAVYQAINRI--TEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLAT 482 G+GPVDA +A+ T+ + +L Y + A G DA+ V++ + R + Sbjct: 427 GSGPVDAAVEAVRAALGTDADAQLDSYHVDAITGGTDAVVTVEVEMSRGDRTVSVATSDS 486 Query: 483 DIVESSAKAMVHVLNNI 499 DI S +AMV L+ + Sbjct: 487 DITRCSVEAMVEALDRL 503 >UniRef50_A6C4F8 2-isopropylmalate synthase n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C4F8_9PLAN Length = 406 Score = 254 bits (649), Expect = 5e-66, Method: Compositional matrix adjust. Identities = 143/361 (39%), Positives = 210/361 (58%), Gaps = 2/361 (0%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V+ DTTLRDGEQ A+L EKLQIA ALE GV ++ GFP SS D +++Q++ Sbjct: 30 VLFSDTTLRDGEQMPGATLDPIEKLQIAKALEAAGVHSLDAGFPASSQADIDAIQSMVGV 89 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFR--IHTFIATSPMHIATKLRSTLDEVIERA 122 +K + AL R + D+D A E+L + + F TSP+H KL + EV++ Sbjct: 90 IKKPVLTALCRTLPGDVDAADEALAGNPPHKRGVSLFCGTSPLHRQFKLEKSKSEVLKLI 149 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + ++ A D V FS EDA RT + L V AI AGATTI PDTVG P++ Sbjct: 150 VDSIQYAAEKFDIVAFSPEDASRTEVDFLCEVYREAIAAGATTIGFPDTVGILTPWKAQD 209 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I + + VP I+ +++VH H+DLGLAV N+LA + AGA V+ +NGIGERAGN +LE Sbjct: 210 FICRIQDEVPGIENVLLAVHFHNDLGLAVANTLACIDAGANVVQCTVNGIGERAGNAALE 269 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV MA+ + ++ ++ ++ +LV+++ + + K + GS FA +GIHQD Sbjct: 270 EVAMALHLHQEEYQRPHQLDVSQLAPLCKLVAELTGIALSPMKPVAGSNIFATEAGIHQD 329 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G+LKN + Y PE++G I+L L SGR A+ HR+ E+G + +E + + A + Sbjct: 330 GLLKNPDTYLPYRPETVGETGIRLVLGRHSGRKAILHRLHELGKEPNEQVVQRVLQAIKE 389 Query: 363 L 363 L Sbjct: 390 L 390 >UniRef50_D2RXB9 Pyruvate carboxyltransferase n=3 Tax=Halobacteriaceae RepID=D2RXB9_9EURY Length = 438 Score = 250 bits (638), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 153/392 (39%), Positives = 218/392 (55%), Gaps = 18/392 (4%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 +FDTTLRDGEQ+ S S +K QIA L+ MG V+E GFPV+S +FE+V+ IA Sbjct: 60 VFDTTLRDGEQSPGTSFSYDDKRQIASILDEMGTHVIEAGFPVNSDAEFEAVRDIASSTS 119 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 + C LAR V+ DI+ A +S +HTF++TS + I + +T DEV+ERA+ V Sbjct: 120 TT-TCGLARVVDADIEAALDS----GVEMVHTFVSTSDVQIEDSMHATRDEVVERAVESV 174 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 +R FS DA RT L ++EA AG INIPDT G P F +I Sbjct: 175 ERVTETGTTCMFSPMDATRTDEQFLLEIIEAVSEAGVDWINIPDTCGVATPTRFRAMI-- 232 Query: 187 LYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIM 246 E+V A I VHTHDD GLA N+LA + AGA Q + ++N IGERAGN + EE +M Sbjct: 233 --EKVCAHTDARIDVHTHDDFGLATANALAGIEAGADQAQVSVNSIGERAGNAAYEEFVM 290 Query: 247 AIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLK 306 A+ + + T I+ I S +V + M P NK +VG AF+H SGIH GV++ Sbjct: 291 AV---ESLYQTDTGIDTTRITELSNVVEEKSGMATPGNKPVVGDNAFSHESGIHAAGVIE 347 Query: 307 NRENYE--IMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 N + +E +MTPE +G + +L L +G +V+ R+ E+G++ ++ + + Sbjct: 348 NSDTFEPGVMTPEMVGAER-RLILGKHTGTHSVRERLAELGFEPTDDQVRAVTRRVKDFG 406 Query: 365 DKKGQVFDYDLEAL---AFIGKQQEEPEHFRL 393 +K +V DLE A I +Q +E E R+ Sbjct: 407 AEKRRVTVDDLERFAEEAGIERQSKEEEEVRV 438 >UniRef50_D2RVT7 Pyruvate carboxyltransferase n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT7_9EURY Length = 508 Score = 249 bits (637), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 171/504 (33%), Positives = 266/504 (52%), Gaps = 22/504 (4%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + V + DTTLRDGEQA SL+ EK+ IA +LE+ GV V+E G + G+ +++ + Sbjct: 13 RTVRLLDTTLRDGEQAPGVSLTPDEKVDIARSLEQAGVSVIEAGSACTGAGERQAISRVT 72 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 ++RV + R +E DID+A + + +H + S HI K+ ++ ++ +E+ Sbjct: 73 DLELDARVTSFCRGMESDIDLALD----CDVDGVHIVVPASDRHIEDKVGTSHEDNLEKT 128 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 +V A+++ VE ED R + L ++ A++AGA I DTVG+T P A Sbjct: 129 AELVAYAKDHDLWVEVIGEDGSRADLDYLEELMATAVDAGADRICFADTVGHTGPERTAE 188 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + L + P +S HTHDDLGL V N+LAAV AGA V +NG+GERAGN +LE Sbjct: 189 AVGRLADVGP------VSAHTHDDLGLGVANALAAVSAGADLVHCTVNGLGERAGNVALE 242 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV +A+ + +V T + E++ +Q VS+ + +P NKA++G AF H SGIH D Sbjct: 243 EVAIAL---SHVYDVET-LELTELYDLAQTVSRATGIQLPPNKAVIGENAFTHESGIHTD 298 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G LK+ + YE PE++G + +L L +GRA V ++E G + + + + Sbjct: 299 GTLKDDKMYEPYAPETVGRER-RLALGKHTGRAGVTATLEEHGVEADSDEVAEIATRVTE 357 Query: 363 LADKKGQVFDYDLEALA--FIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 L D+ +V D DL A+A G +E LD + G+ + TA+V+L E + Sbjct: 358 LGDRGRRVTDADLLAIAEDVTGDDRERVVEL-LDLNATSGGA--VPTASVRLEVDGEERV 414 Query: 421 EAANGNGPVDAVYQAINRI--TEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGV 478 + G+GPVDA A+ + + EL Y + A G DA+ V++ N R Sbjct: 415 ASGTGSGPVDAAVSAVREALGSMADAELDSYHVDAVTGGTDAVVTVEVTMMRNDRSVTVA 474 Query: 479 GLATDIVESSAKAMVHVLNNIWRA 502 DI +S +AMV L+ + A Sbjct: 475 RSEADITRASVEAMVDALDRLLAA 498 >UniRef50_Q56216 2-isopropylmalate synthase (Fragment) n=1 Tax=Thermus thermophilus RepID=LEU1_THETH Length = 331 Score = 248 bits (633), Expect = 4e-64, Method: Compositional matrix adjust. Identities = 137/298 (45%), Positives = 188/298 (63%), Gaps = 4/298 (1%) Query: 198 IISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNV 257 +IS HTHDDLG+A N+LA V GA Q+E +NGIGERAGNC+LEEV+MA+ VR+D Sbjct: 11 VISTHTHDDLGMATANALAGVENGAGQIECTINGIGERAGNCALEEVVMALYVRRDWYKA 70 Query: 258 HTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPE 317 +T IN +EI+R S+LV + MP+P NKAIVG AFAH SGIHQDGV+K+R YEIM E Sbjct: 71 YTRINTREIYRVSRLVERYTGMPVPPNKAIVGDNAFAHESGIHQDGVIKHRATYEIMDAE 130 Query: 318 SIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE-SEYNLDNLYDAFLKLADKKGQVFDYDLE 376 IG L L SGRAA K ++++GYK+ SE + L+ F ++A+KKG + +L+ Sbjct: 131 LIGRRPAVLVLGKHSGRAAFKKALEDLGYKDLSEEEVKKLFARFKEIAEKKGPLSAEELQ 190 Query: 377 ALAFIGKQQEEPEH-FRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQA 435 AL + ++E H F+L++ SGS + TA VK+ + + G+GPVDAVY+A Sbjct: 191 AL--VESEREPTSHFFQLEHVQFFSGSGLLPTATVKVKTPDGERLATHTGDGPVDAVYKA 248 Query: 436 INRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMV 493 I EL Y + A +ALGQV + + GVG++ DI+E+SA A + Sbjct: 249 IQEAIGLRPELELYRVEAITGSTEALGQVTVRLRLGELQAVGVGVSPDIIEASALAFL 306 >UniRef50_B9LUZ7 Pyruvate carboxyltransferase n=1 Tax=Halorubrum lacusprofundi ATCC 49239 RepID=B9LUZ7_HALLT Length = 387 Score = 248 bits (632), Expect = 5e-64, Method: Compositional matrix adjust. Identities = 147/391 (37%), Positives = 217/391 (55%), Gaps = 15/391 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V IFDTTLRDGEQ+ + S S EK +IA L+ M V+E GFPV+S +FE+V IA Sbjct: 10 VRIFDTTLRDGEQSPRTSFSYDEKRRIAATLDDMNTHVIEAGFPVNSDAEFEAVSDIA-A 68 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 N+ VC LAR VE DID A +S +H F++TS + + + +T E +RA+ Sbjct: 69 ATNTTVCGLARVVEGDIDAAIDS----GVEMVHVFVSTSDVQLEDSMHATRQEAKQRAVA 124 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 V++ ++ + FS DA RT L +VEA +AG INIPDT G MP F + Sbjct: 125 AVEQVKDAGVECMFSPMDATRTDPDYLREIVEAVSDAGTDWINIPDTCGVAMPTSFGKTV 184 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 V N A + VHTHDD G+A N++ GA Q + ++NGIGERAGN + EEV Sbjct: 185 KA----VVNATDARVDVHTHDDFGMAAANAVMGFENGAEQAQVSVNGIGERAGNAAYEEV 240 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 +MA+ + + V T I+ +I + +++V + ++P+PANK + G AFAH SGIH GV Sbjct: 241 VMAV---ESVYGVDTGIDTTQITKLARIVEEASDIPVPANKPVTGRNAFAHESGIHAAGV 297 Query: 305 LKNRENYE--IMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 ++N + +E +MTPE +G + + L +G +V+ + E G+ ++ + + + Sbjct: 298 IENADTFETGVMTPEMVGAER-EFVLGKHTGTHSVRKHLVEAGFDPTDSEVRRITKRVKE 356 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRL 393 K QV D+E A E E R+ Sbjct: 357 YGSGKRQVTAGDVERFAEEADIDREEEEVRI 387 >UniRef50_C9YAE2 Putative uncharacterized protein n=1 Tax=Curvibacter putative symbiont of Hydra magnipapillata RepID=C9YAE2_9BURK Length = 285 Score = 240 bits (612), Expect = 1e-61, Method: Compositional matrix adjust. Identities = 124/222 (55%), Positives = 159/222 (71%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+ ++IIFDTTLRDGEQ+ AS++ EKL+IA LER+ VDV+E GF SS GDFE+VQ Sbjct: 1 MTDKLIIFDTTLRDGEQSPGASMTRDEKLRIARQLERLRVDVIEAGFAASSNGDFEAVQL 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 IA +K+S VC+L+R ++DI AAE+LK A + RIHTFIATS +H+ KLR T ++V+E Sbjct: 61 IANSIKDSTVCSLSRANDRDIARAAEALKGANSARIHTFIATSALHMEKKLRMTPEQVLE 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 +A V+ ARN D+EFS ED R+ L RV+EA I GA+TIN+PDTVGY +P + Sbjct: 121 QAKQSVRFARNLVADIEFSPEDGYRSDPDFLCRVLEAVIAEGASTINVPDTVGYAVPELY 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGA 222 I L ER+PN DKAI SVH H+DLG+AV NSLA V G Sbjct: 181 GNFIKNLRERIPNSDKAIWSVHCHNDLGMAVANSLAGVKIGG 222 >UniRef50_Q57926 2-isopropylmalate synthase 1 n=16 Tax=Euryarchaeota RepID=LEU11_METJA Length = 398 Score = 239 bits (609), Expect = 2e-61, Method: Compositional matrix adjust. Identities = 143/344 (41%), Positives = 202/344 (58%), Gaps = 12/344 (3%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + + I+DTTLRDGEQ + ++KL+IA L+ +G+ +E GFP+ S + + V+TIA Sbjct: 22 KDIYIYDTTLRDGEQTPGVCFTKEQKLEIARKLDELGLKQIEAGFPIVSEREADIVKTIA 81 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRS-TLDEVIER 121 + N+ + AL R ++KDID A E + I TFIATSP+H+ K + +LDE++E Sbjct: 82 NEGLNADILALCRALKKDIDKAIE----CDVDGIITFIATSPLHLKYKFNNKSLDEILEM 137 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 + V+ A+ + V FS EDA RTPI DL +V +AA AGA ++I DT G P Sbjct: 138 GVEAVEYAKEHGLFVAFSAEDATRTPIEDLIKVHKAAEEAGADRVHIADTTGCATPQSME 197 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 I L E N+ KA I VH H+D G AV NS+ + GA+ V +NGIGERAGN +L Sbjct: 198 FICKTLKE---NLKKAHIGVHCHNDFGFAVINSIYGLIGGAKAVSTTVNGIGERAGNAAL 254 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EE+IMA+ V D V +N + + ++V + + +P NK IVG FAH SGIH Sbjct: 255 EELIMALTVLYD---VDLGLNLEVLPELCRMVEEYSGIKMPKNKPIVGELVFAHESGIHV 311 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMG 345 D V++N YE PE IGL + + L SG AV +++ MG Sbjct: 312 DAVIENPLTYEPFLPEKIGLKR-NILLGKHSGCRAVAYKLKLMG 354 >UniRef50_UPI000038E0F9 2-isopropylmalate synthase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0F9 Length = 388 Score = 234 bits (596), Expect = 8e-60, Method: Compositional matrix adjust. Identities = 135/367 (36%), Positives = 212/367 (57%), Gaps = 21/367 (5%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + + IFDTTLRDGEQ S + +K +IA L GV+++E GFP S + +S++ I Sbjct: 28 ENISIFDTTLRDGEQTPGVSFNTDQKYKIAKMLYDAGVNIIEAGFPAVSNDEMKSIKKIN 87 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 ++N +C+LARC DID ES ++ IH FIATS +H+ KL+ T ++V + Sbjct: 88 HDMEN--ICSLARCNRNDIDKVIES----DSRIIHLFIATSDIHMKYKLKKTREQVFDSI 141 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + + AR+Y + FS EDA RT + L ++V + TIN PDT+G P Sbjct: 142 MESIDYARSYGMRIIFSPEDATRTSMDFLKQIVSSI---KVETINFPDTIGIMNPISMYY 198 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I+ ++ + IS+H H+D G+A N+LA + AGA + + +NGIGERAGN SLE Sbjct: 199 FIN----KIKSFTSTGISIHCHNDFGMATANTLAGLMAGANEAQVTVNGIGERAGNASLE 254 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV+ +I LN +T I ++++ S+ VS + NKAI G AF+H +GIH Sbjct: 255 EVVSSI---YGFLNSYTDIKMEKLYSISKYVSAASGIIPQKNKAITGENAFSHEAGIHVQ 311 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G++ N + YE + PE GLN+ ++ + SG+AA+K+ ++ G +++ +DN+ L+ Sbjct: 312 GIINNPKTYEAINPEIFGLNR-RIVIGKHSGKAAIKYILENNGMHKTDDEIDNI----LQ 366 Query: 363 LADKKGQ 369 + K+G Sbjct: 367 IVKKEGN 373 >UniRef50_Q6L0K4 2-isopropylmalate synthase n=1 Tax=Picrophilus torridus RepID=Q6L0K4_PICTO Length = 386 Score = 231 bits (590), Expect = 3e-59, Method: Compositional matrix adjust. Identities = 138/348 (39%), Positives = 205/348 (58%), Gaps = 14/348 (4%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ IFDTTLRDGEQ+ S ++ +K +IA L +GVD++E GF S + +++ I Sbjct: 27 KRIRIFDTTLRDGEQSPGVSFNINQKARIAGMLVDLGVDMIETGFAAVSSEESMAIRKIH 86 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 N +LARC DID ++ IH FIATS +HI KL+++ + ++E+ Sbjct: 87 EMDGN--FISLARCNRHDIDSVIDT----GIDNIHLFIATSDIHIKYKLKTSRENIMEKI 140 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + + AR++ +V FS EDA RT + L V+ AI++GA INIPDT+G P Sbjct: 141 VDSIDYARSHGLNVLFSPEDATRTDMNFLIDVINTAISSGAYEINIPDTIGIMNPISMYN 200 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I + N K+ ISVH H+D G+A N+LAA+ AGA + +NGIGERAGN +LE Sbjct: 201 FI----HEIKNRTKSCISVHCHNDFGMATANTLAAIMAGADGAQVTVNGIGERAGNAALE 256 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV++++ D T IN + I + S+ VS M I NKAIVG AF+H SGIH Sbjct: 257 EVVLSVHAFTD---CSTGINMRMIPKISKYVSMASKMYIQKNKAIVGENAFSHESGIHVH 313 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESE 350 G++ N E YE + P +GLN+ ++ L SG ++K+ ++ G K+S+ Sbjct: 314 GLINNPETYEPIDPGILGLNR-RIVLGKHSGTTSLKYILESHGIKKSD 360 >UniRef50_D2RHQ3 Isopropylmalate/citramalate/homocitratesynthase n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RHQ3_ARCPR Length = 529 Score = 230 bits (586), Expect = 1e-58, Method: Compositional matrix adjust. Identities = 172/540 (31%), Positives = 268/540 (49%), Gaps = 62/540 (11%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I DTTLRDGEQ SL+V++KL IA AL+ +GVDV+E G ++ +F +V+ IA Sbjct: 4 ILDTTLRDGEQTPGVSLTVEQKLIIAQALDDLGVDVIEAGTAIAGEEEFRAVKEIANAGL 63 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKL-RSTLDEVIERAIYM 125 + +C+ AR E DID A A+A + +S +HI TK + D++IE ++ Sbjct: 64 KAEICSFARIKEIDIDAVAN----ADADSVFMVAPSSDIHIKTKFPNKSGDDIIEMSVKA 119 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 V+ A+ VEF ED+ R + + + A ++AGA + DTVG P + I+ Sbjct: 120 VEYAKERGLIVEFGAEDSSRANLNFVKALFRAVLDAGADRLTFTDTVGVLTPEKAECIMR 179 Query: 186 GLYER--VPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 L VP I+ H H+D GLA N++ AV GAR++ +NG+GERAGN LEE Sbjct: 180 ELTSEFNVP------IAFHGHNDFGLATANTIFAVKGGAREIHVTINGLGERAGNAPLEE 233 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 V++A++ + T I ++I+ TS+LV + PI NK IVG AF H SGIH Sbjct: 234 VVLALET---FYGIKTKIRKEKIYDTSKLVEALTRFPIALNKPIVGYNAFMHESGIHTSA 290 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 +L+N + YE ++PE IG + ++ SG+A++ ++E+GY+ S + + ++ Sbjct: 291 LLRNAKAYEPISPEMIGRKRAIVH-GKHSGKASIMRLIEELGYEASGEQVKEIMKRIKEM 349 Query: 364 ADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLAC--GEEVKAE 421 + +V DL + + ++ + L +V G + + A C GE+++A Sbjct: 350 EGRGQKVMGSDLIKIIEEVLKVKKGKKIVLKGLNVVCGKSGTSPHASIKICLNGEDIEAT 409 Query: 422 AANGNGPVDAVYQAI-NRITEY-------------NVELVKYSLTA-------------- 453 A G GP DA +A+ N + EY NV+LV Y A Sbjct: 410 AL-GKGPFDASIRALKNALKEYANKSGDKAVGELVNVKLVNYKANAIIDDKVIEYIEKLV 468 Query: 454 ------KG--------HGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNI 499 G G DA V I + R +G +TDI+ +S +A + LN + Sbjct: 469 EKNPKLSGLVEKIRIMTGTDAPVDVIIQLEKDDRVVTAIGRSTDIIHASVEAYIECLNKL 528 >UniRef50_C4XS62 Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio magneticus RS-1 RepID=C4XS62_DESMR Length = 394 Score = 229 bits (585), Expect = 1e-58, Method: Compositional matrix adjust. Identities = 142/364 (39%), Positives = 195/364 (53%), Gaps = 4/364 (1%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 +II DTTLRDG Q S+ +K+ IA ALE GVDV+E GFP G+ E+V+ +A Sbjct: 10 LIISDTTLRDGAQMPGVHFSINDKVAIAQALEAAGVDVIEAGFPAGGAGEIEAVRQVAAA 69 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFR--IHTFIATSPMHIATKLRSTLDEVIERA 122 + AL R V+ D+D A ++L A A R + F+ATSP+H KL T + + Sbjct: 70 TARPLIMALCRAVDADVDAAWQALGDAPAERRGVGVFLATSPLHRRHKLGKTKAQCLAMI 129 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 V AR V F CED RT A L AA++AGAT I PDTVG P E A Sbjct: 130 ASSVAYARQRFARVTFGCEDGSRTEPAFLREAYTAAMDAGATAIGFPDTVGVLTP-ETAR 188 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + R+ + H H+DLGLA N+LAA+ AGA V + GIGERAGN +LE Sbjct: 189 RRIAMLVRLAQPRGVKVRAHFHNDLGLATANTLAAIAAGADIVHLTVGGIGERAGNAALE 248 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E +MA+ + ++ + +LV+Q +P NKA+ G+ FA ++G+HQD Sbjct: 249 ETVMALTLHPGQYRRAINVDTTRLTALCRLVAQRAGFTLPPNKAVTGANVFATAAGVHQD 308 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G+LK+ + Y PE +G I+L L+ SG+AA+ R E+G S L +K Sbjct: 309 GLLKHPDTYLPFRPELVGAEGIRLPLSPLSGKAALALRYTELGIALSADELSR-ASRLVK 367 Query: 363 LADK 366 ADK Sbjct: 368 DADK 371 >UniRef50_C9RKZ6 Pyruvate carboxyltransferase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RKZ6_FIBSS Length = 518 Score = 229 bits (585), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 171/527 (32%), Positives = 268/527 (50%), Gaps = 37/527 (7%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 +++ +D TLRDG QAL + +K + L L ++GV EVGFP SS DFESV + Sbjct: 4 TRKPFFYDVTLRDGNQALPKPWNNAQKKDVYLLLLKLGVQGAEVGFPASSEMDFESVMEL 63 Query: 62 ARQV-----------KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATK 110 A+ KN V LARC+E DI E+++ A RIHTF+ATSP+ + Sbjct: 64 AKLTAQMAEEGDEVAKNVVVSGLARCIESDIQRCWEAVQYAPHPRIHTFLATSPLSMENV 123 Query: 111 LRSTLDEVIERAIYMVKRARNYT---DDVEFSCEDAGRT--PIADLARVVEAAINAGATT 165 L T ++V E+A+ VK A++ DVEFS E G + + V++A + AGATT Sbjct: 124 LHMTPEQVKEKAVKCVKFAKSLVGDRGDVEFSAEHFGDCLENMDFVIDVLKAVVEAGATT 183 Query: 166 INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQV 225 IN+P+TV P + + +YE +P ISVH H+DLG+A ++ + GA Q+ Sbjct: 184 INLPNTVERYRPKLYVDQVKQVYEALPK--NITISVHCHNDLGMATAATVESFFVGATQL 241 Query: 226 EGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANK 285 E A+NG+GER GN + EV + + V T ++ + I+ T+ LVS +PI Sbjct: 242 EVALNGLGERCGNTNFYEVAIGLHNS----GVDTGLHLERIYETAILVSHWSGVPIYIRA 297 Query: 286 AIVGSGAFAHSSGIHQDGVLKNRE----NYEIMTPESIGLNQ-IQLNLTSRSGRAAVKHR 340 ++G+ A H SGIHQDG K ++ Y + IG NQ L+ TS+SGR AV Sbjct: 298 PLIGTEAIVHRSGIHQDGASKTKDMKKGAYRPIDYSIIGRNQNDTLSFTSQSGRTAVYEI 357 Query: 341 MDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQS 400 + + GYK + L +L++ +G++ E + + ++Q + RL + +++ Sbjct: 358 ITKFGYKMTLQEASKLQPVLKRLSEAEGEL---SAERVLDVFREQFVNVNGRLVFNNIEV 414 Query: 401 GSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDA 460 ++ E ++ GP++A + I VELVKY KD Sbjct: 415 IPDE-NRFIFHFKKDGEALVKSVTAEGPIEAALMLMREIG-MPVELVKYRQLVVPE-KDK 471 Query: 461 L----GQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAA 503 L G IV NG G G+++D ++++ +A+ +N I++ A Sbjct: 472 LWAGRGLSRIVLKANGEEVEGRGVSSDTLKANMRALFGGVNLIYKKA 518 >UniRef50_O66682 Uncharacterized AIPM/Hcit synthase family transferase aq_356 n=44 Tax=Bacteria RepID=LY41_AQUAE Length = 528 Score = 215 bits (548), Expect = 3e-54, Method: Compositional matrix adjust. Identities = 162/522 (31%), Positives = 270/522 (51%), Gaps = 41/522 (7%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+++V I+DTTLRDG Q S S+++K++IA L+ G+ +E G+P ++P D Q Sbjct: 1 MAEKVYIYDTTLRDGSQMEGVSFSLEDKIRIAEKLDDFGIHYIEGGWPYANPKDNLFFQK 60 Query: 61 IAR-QVKNSRVCALA--RCVEKDI--DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + KN+++ A R K + D ESL AE + F + +H+ L++TL Sbjct: 61 AKKMNFKNAKLTAFGSTRRPNKKVSEDPQVESLIKAETPVVTIFGKSWDLHVTDALKTTL 120 Query: 116 DEVIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTV 172 +E + V+ + Y D+V F E D ++ +V+EAA+ GA + + DT Sbjct: 121 EENLNMIYETVEYLKRYVDEVIFDAEHFFDGYKSNPEYALQVLEAALKGGADWVVLCDTN 180 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G T+P E I + ER + A + +H H+D AV NSL AV AGARQV G +NGI Sbjct: 181 GGTLPHEIYEITKKVKERFKD---ANVGIHAHNDSETAVANSLMAVLAGARQVHGTINGI 237 Query: 233 GERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 GER GN +L +I ++++ +V N +++ + V++I NMP+P N VG A Sbjct: 238 GERTGNANLCSIIPNLQLKLG-FDVIPQENLKKLTELANFVAEIINMPLPRNMPYVGESA 296 Query: 293 FAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK--ESE 350 FAH G+H VLKN + YE + PE +G N+ ++ ++ +GR+ + H++ E G + Sbjct: 297 FAHKGGVHASAVLKNAKTYEHINPELVG-NKRKITVSDLAGRSNLVHKLKEFGIEIDPKS 355 Query: 351 YNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRL--DYFSV---------- 398 L L D +L +K+G F+ +L + K+ HF L DYF Sbjct: 356 PELKKLIDKIKEL-EKEGYHFEAAEASLELLIKR-----HFGLVKDYFDFDAYRVLIAKR 409 Query: 399 QSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITE------YNVELVKYS-- 450 + S + A V+L+ + A+ GNGP+ A+ +A+ + E ++L+ Y Sbjct: 410 RDDSLPTSEATVRLSVEGVEEHTASLGNGPISALDRALRKALEEFYPNLKELQLIDYKVR 469 Query: 451 LTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAM 492 + + G A +V I + R++ VG++ +++E+S A+ Sbjct: 470 IINESAGTSAKVRVLIESTDGKRKWGTVGVSENVIEASWIAL 511 >UniRef50_P58967 2-isopropylmalate synthase 1 n=9 Tax=Euryarchaeota RepID=LEU11_METMA Length = 405 Score = 214 bits (545), Expect = 7e-54, Method: Compositional matrix adjust. Identities = 137/394 (34%), Positives = 214/394 (54%), Gaps = 15/394 (3%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I D TLRDGEQ S ++KL +A L+ MG++V+E GFPV S + E V+ IA Q Sbjct: 25 ICDVTLRDGEQTPGVVFSKEQKLAVASELDSMGIEVIEAGFPVVSADEKEIVKEIANQGF 84 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 NSR+C L+R V+ D+D A E + + FIA S MH+ K +L++++ A + Sbjct: 85 NSRICCLSRAVKGDVDAALE----CDVDIVSIFIAMSDMHLKYKYHRSLEDMLGCAKEAI 140 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINA-GATTINIPDTVGYTMPFEFAGIIS 185 + A ++ V F+ EDA RTP+ L + + N +++ DTVG P ++S Sbjct: 141 EYATDHGLKVRFAAEDASRTPVERLKQAFKEVENEYKVQYVSLADTVGILNPTTTNYLVS 200 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245 +++ V I +H HDDLG+A N+LAA AGA+Q+ +N IGERAGN SLEEV+ Sbjct: 201 EIFKSV----NTAICIHCHDDLGMATANTLAAAEAGAKQLHTTVNAIGERAGNASLEEVL 256 Query: 246 MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVL 305 +A++V+ I T ++ S++VS+ + NKA+VG AF H SGIH +L Sbjct: 257 VALRVQYGIERYDTT----KLNSLSEMVSEYSGITPSVNKAVVGKNAFTHESGIHVAAIL 312 Query: 306 KNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLAD 365 + YE+ PE +G + L + +G+ A+K ++ +G+ L L + + Sbjct: 313 EEPRTYELFLPEMVG-GKRNLVVGKHTGKKALKGIINSIGFCLEREELCALIEKVKVCTE 371 Query: 366 KKGQVFDYD-LEALAFIGKQQEEPEHFRLDYFSV 398 +K + D LE L KQ+++P + FS+ Sbjct: 372 EKHKSISRDQLERLITQVKQEQKPSGSEKEKFSI 405 >UniRef50_B4B8D2 Pyruvate carboxyltransferase n=1 Tax=Cyanothece sp. PCC 7822 RepID=B4B8D2_9CHRO Length = 277 Score = 212 bits (540), Expect = 3e-53, Method: Compositional matrix adjust. Identities = 116/276 (42%), Positives = 170/276 (61%), Gaps = 6/276 (2%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +S+Q++I DTT+RDGE +S EKL++A LE VD++EV +P S DF+ + Sbjct: 4 LSEQILILDTTMRDGELVPGIKMSQAEKLRLAQLLEEAKVDIIEVSYPAKSQQDFDEIVA 63 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 ++R++KNS VCAL+ ++I+ AA LK A RIH + S +++A K E + Sbjct: 64 VSREIKNSIVCALSNLSVQEIERAATGLKSASRGRIHLY---SNVNLAKKEPLKRQEALS 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 V ARNY DD+E+S DA R+ + L R +E AIN+GA TINIPD++G +P EF Sbjct: 121 MIQQGVTLARNYCDDIEWSAFDASRSDLDFLCRGIEMAINSGAKTINIPDSLGVLLPAEF 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 A ++ ++ RVPNIDK+I+SVH HDD A+ NSL A+ G RQ+E ++NG+G R GN + Sbjct: 181 AQLLEKIFTRVPNIDKSIVSVHCHDDCEQALLNSLIALEVGVRQIECSLNGLGARKGNAN 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQI 276 L+ VI I T++ ++I +LV QI Sbjct: 241 LKSVIKEIDQNP---TYKTSVILEKIPPAEELVKQI 273 >UniRef50_D2L197 Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio sp. FW1012B RepID=D2L197_9DELT Length = 400 Score = 210 bits (534), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 130/332 (39%), Positives = 187/332 (56%), Gaps = 3/332 (0%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 +I+ DTTLRDG Q SV +K+ IA AL GV V+E GFP S + E+V+ I + Sbjct: 17 LILSDTTLRDGAQMPGVRFSVDDKVAIAKALADAGVGVIEAGFPAGSEREIEAVRRICAE 76 Query: 65 VKNSRVCALARCVEKDIDVAAESLKV--AEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 V R+ L R V DID A E+L E + F+ATSP+H KL + + ++ Sbjct: 77 VPGPRIMVLCRAVAGDIDAAWEALADAAPEGRGVGIFLATSPLHRRHKLGKSKAQCLDMI 136 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 V AR V FSCED RT A L + A++AGAT I PDT+G P Sbjct: 137 GRAVAYARKRFLKVTFSCEDGSRTEPAFLRQAYGVAMDAGATGIGFPDTLGVLTPEAVRR 196 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + + + + + VH H+DLGLA N+LAAV AGA V + GIGERAGN +LE Sbjct: 197 RVR-MLAALAHPRGVRLRVHFHNDLGLATANTLAAVAAGADIVHLTVGGIGERAGNAALE 255 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E +MA+ + + ++ ++ +LVS++ +P+ ANKA+VG+ FA S+G+HQD Sbjct: 256 ETVMALILNQKQYRRSIGVDPAKLTGLCRLVSRLSGVPLAANKAVVGANIFATSAGVHQD 315 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGR 334 G+LK+ + Y PE++G + I+L L+ SG+ Sbjct: 316 GLLKHPDTYLPFRPEAVGADGIRLPLSPLSGK 347 >UniRef50_A6FCI3 2-isopropylmalate synthase n=1 Tax=Moritella sp. PE36 RepID=A6FCI3_9GAMM Length = 387 Score = 207 bits (528), Expect = 6e-52, Method: Compositional matrix adjust. Identities = 119/356 (33%), Positives = 193/356 (54%), Gaps = 4/356 (1%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ I DTTLRDGEQA + ++ ++KL++AL LE GVD +E GFP SS D+E+ + I+ Sbjct: 2 KKISILDTTLRDGEQAPENAMDPEKKLKMALMLEECGVDHIETGFPASSKFDYEATKLIS 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 ++V S + +R + D+ ++ ES + I S +H+ K + + IE Sbjct: 62 KEVTQSGIATFSRTLTSDVQLSLESGGREKNHTIQMVATGSDLHLKNKRNISRSQAIEEV 121 Query: 123 IYMVKRARNYTD-DVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 I VK A+ +D + EDA R + + EAA+ AGA I + DT GY P EF Sbjct: 122 INTVKFAKQNSDCRIAVGIEDASRADFDFMGEITEAAVFAGAHQIILADTTGYATPSEFK 181 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 +I + R D IS H H+DLGLA N+LA + GA +V+ + GIGERAGN SL Sbjct: 182 KLIQ--FIRSKTGDGISISTHCHNDLGLAHANTLAGIEGGADEVQVTLGGIGERAGNASL 239 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 E + + + + + T I ++++ Q + + IP N+ + G+ AF+ ++GIHQ Sbjct: 240 EMIASTLFFKPECYSSFTDIKLDKLYKVYQELCSEIGLDIPRNQPVFGTYAFSTAAGIHQ 299 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 GVL N + YE + P+ + + ++ SG++ +K+ + + L+ LY Sbjct: 300 QGVLANPDTYEFVKPDVFNRER-EFFVSRHSGKSIIKYILSNKAMDQDPKLLETLY 354 >UniRef50_Q2FKU8 2-isopropylmalate synthase n=3 Tax=Methanomicrobiales RepID=Q2FKU8_METHJ Length = 393 Score = 204 bits (519), Expect = 6e-51, Method: Compositional matrix adjust. Identities = 124/340 (36%), Positives = 185/340 (54%), Gaps = 13/340 (3%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I D TLRDGEQ S + EK IA L+ +G++V+E GFP+ S + E V+ I+R Sbjct: 8 ICDVTLRDGEQTPGVSFTADEKKDIASRLDAIGIEVIEAGFPIVSAHEKEMVRNISRLGL 67 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 ++++C L+R +D+D A + AE I FIA S +H+ K + D V+ A+ + Sbjct: 68 SAKICGLSRACREDVDAALD----AEVDMIGLFIAPSDLHLKYKHKKPRDVVVANALEQL 123 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 A ++ V F EDA RT L + A + AT + DT G P E A ++ Sbjct: 124 DYAVDHGLIVRFGAEDASRTDPDILVDIYRQAADHKATYVTYADTTGCLTPLEVATVMKD 183 Query: 187 LYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIM 246 L + P I++H H+DLG A N+L A GA Q+ +NG+GERAGN LEEV++ Sbjct: 184 LVPKTP----IPIAMHAHNDLGCATANTLIAAELGAYQLHTTVNGLGERAGNARLEEVLV 239 Query: 247 AIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLK 306 ++ ++ I T + EI S+ V Q + +PA K +VG+ AFAH SGIH +L+ Sbjct: 240 SLVLKGGI----TRYDLTEIPALSERVQQYTGIFMPATKPVVGANAFAHESGIHIAAILE 295 Query: 307 NRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGY 346 N E YE + PE +GL + + L +G+ A+ H + GY Sbjct: 296 NPETYEFIPPELLGLER-RFILGKHTGKRALVHILTSFGY 334 >UniRef50_C3MPM7 2-isopropylmalate synthase n=19 Tax=Thermoprotei RepID=LEU1_SULIL Length = 461 Score = 204 bits (519), Expect = 8e-51, Method: Compositional matrix adjust. Identities = 119/357 (33%), Positives = 191/357 (53%), Gaps = 16/357 (4%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 +V I D+TLR+GEQ +V ++++IA AL +GV ++E G P SP +E ++ I + Sbjct: 3 KVGILDSTLREGEQTPGVIFTVDQRVEIAKALSDLGVSMIEAGHPAVSPDIYEGIKRIVK 62 Query: 64 QVK----NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 K S + +R V++DI++AAE E RI F S +H+ K ++T +E + Sbjct: 63 LKKEGIITSEIVGHSRAVKRDIEIAAE----LEVNRIAIFYGVSDLHLKAKHKATREEAL 118 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE 179 + A+N+ V F+ ED RT L V + A +AGA ++I DTVG P + Sbjct: 119 RTIAETISYAKNHGVKVRFTAEDGSRTDFDFLVTVSKTARDAGADRVSIADTVGILYPSK 178 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 + S L VPN++ +H H+DLGLAV N+LAA+ GA + +NG+GER G Sbjct: 179 TKELFSALTREVPNLE---FDIHAHNDLGLAVANALAAIEGGATIIHATVNGLGERVGIV 235 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 L+++ AIK I + ++ S LV + +P+P N I G AF H +G+ Sbjct: 236 PLQQIAAAIKYHFGI----EVVKLDKLQYVSSLVEKYSGIPMPPNYPITGDYAFLHKAGV 291 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNL 356 H GVL + YE M PE+ G + + +G+ A++ + +++G K S+ +D + Sbjct: 292 HVAGVLNDPRTYEFMPPETFGRTR-DYTIDKYTGKHALRDKYEKLGVKISDAEMDQI 347 >UniRef50_C8WE03 Homocitrate synthase n=3 Tax=Zymomonas mobilis RepID=C8WE03_ZYMMN Length = 402 Score = 200 bits (509), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 135/358 (37%), Positives = 196/358 (54%), Gaps = 13/358 (3%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + +II DTTLRDGEQA + ++ EKL IA AL+ GVD +E G P + E+++ I Sbjct: 7 KHLIINDTTLRDGEQAPGVAFTLSEKLHIAKALDEAGVDEIEAGIPAMGASEIEAIRQIV 66 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRS-TLDEVIER 121 +Q + +RV R D+D A E+ A +H I++SP +A K + +++ Sbjct: 67 QQSQTARVIPWCRMKISDVDKALET----GAKTVHLSISSSPFQMAAKFPDLSAADILGL 122 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 ++ A++ DV EDA R I+ L ++ AGA I DT+G PF Sbjct: 123 CQKVISYAKDRGLDVSVGAEDASRAEISFLTDLLGVIEEAGAFRIRFADTLGILDPFATY 182 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 IIS L++ P +D I H HDDLGLA NSLAA+ AGA+ + G+GERAGN L Sbjct: 183 EIISQLHQISP-LD---IEFHGHDDLGLATANSLAAIKAGAKGASVTVLGLGERAGNAPL 238 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 E+V++A I T I ++++ +Q V+Q IP +KAIVG F H SGIH Sbjct: 239 EQVVIA---ASHIAGKETRILPEKLYNLAQYVAQAAGRTIPPDKAIVGEAVFQHESGIHV 295 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 G+L+N +YE + PE +G Q ++ L SGRAA++H + +G K E + NL A Sbjct: 296 AGLLRNPASYEALNPEKLG-RQREIVLGKHSGRAAIRHALSLLGIKAQEDMIQNLLAA 352 >UniRef50_Q2RGA1 2-isopropylmalate synthase n=5 Tax=Clostridia RepID=Q2RGA1_MOOTA Length = 533 Score = 196 bits (498), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 162/524 (30%), Positives = 266/524 (50%), Gaps = 47/524 (8%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+++++I+DTTLRDG Q SLSV++KL+IA L+R+GVD +E G+P ++P D E Sbjct: 1 MAEKILIYDTTLRDGSQGEGISLSVEDKLKIASRLDRLGVDYIEGGWPWANPKDMEFFLR 60 Query: 61 IARQV--KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIAT-----SPMHIATKLRS 113 AR+V + +R+ A R K AAE + R +AT +H+ L + Sbjct: 61 -AREVIWRQARLVAFGR-TRKPGQAAAEDANLLAIKRAGVKVATIFGKSWDLHVTAALGT 118 Query: 114 TLDE----VIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIP 169 TL E + + ++V + D E + P L ++AA AGA+ I + Sbjct: 119 TLAENLAMIGDSVAFLVDQGLEVIYDAEHFFDGFKANPDYAL-ETLKAAAKAGASWIVLC 177 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT G +P+E ++ RV + + +H H+D LAV N+LAAV AG RQV+G + Sbjct: 178 DTNGGCLPWEIEEAVA----RVRQEIQVPVGIHAHNDGDLAVANTLAAVTAGCRQVQGTI 233 Query: 230 NGIGERAGNCSLEEVI--MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAI 287 NG GER GN L V+ + +K+ L E+ S+ VS+I N+ N+ Sbjct: 234 NGFGERCGNADLCSVMPNLELKMGYQCLPPGQLAFLTEV---SRYVSEIANVVPAGNQPF 290 Query: 288 VGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK 347 VG AFAH GIH VLK + YE + P+ +G N+ ++ ++ ++G + ++ + +EMG + Sbjct: 291 VGYSAFAHKGGIHVSAVLKAPDTYEHIRPQQVG-NERRVLMSDQAGASNLRCKAEEMGLE 349 Query: 348 ESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQ-EEPEHFRLDYFSV----QSGS 402 + + + +L + Q D F+ K E + F ++Y ++G Sbjct: 350 LNPERERGIIEGIKELERQGYQFEGADASLELFLRKTTGEYRQQFEVEYVKALVEKRAGQ 409 Query: 403 NDIATAAVKLACGEEVKAEAANGNGPVDA-----------VYQAIN--RITEYNVELVKY 449 I+ A VKL G++V AA GNGPV+A V+ AI R+T+Y V ++ Sbjct: 410 EAISEAIVKLRVGDQVVHTAAEGNGPVNAMDNALRKALEEVFPAIRHMRLTDYKVRVLD- 468 Query: 450 SLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMV 493 + A +V I + ++ VG++T+I+E+S +A++ Sbjct: 469 ----EKDATSARVRVLIESRDGSNSWNTVGVSTNIIEASWEALL 508 >UniRef50_B1L4G2 Pyruvate carboxyltransferase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L4G2_KORCO Length = 495 Score = 195 bits (496), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 152/507 (29%), Positives = 258/507 (50%), Gaps = 34/507 (6%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPG-------DFESVQ 59 IFD+TL GE S ++ KL+IA L+ +GVDV+E GFP SS G +V+ Sbjct: 4 IFDSTLTLGEMVPGVSFGLEGKLEIASHLDTLGVDVIEAGFPASSEGEKRVVREVVRNVK 63 Query: 60 TIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 ++R + VCALAR + +D+ A E+ ++ FI S + + +E Sbjct: 64 RLSRSGLSPEVCALARAIREDVKAAVET----GVDSVNIFIPASRLLLERAYGMREEEAR 119 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTP--IADLARVVEAAINAGATTINIPDTVGYTMP 177 ER V A+++ VEF+ EDAGR+ + DL R+ E +GA IN+ D VG +P Sbjct: 120 ERVREAVSLAKSHDLTVEFTAEDAGRSDDLLWDLCRIAE---ESGADRINLSDPVGAMLP 176 Query: 178 FEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 + I+ +R+ + ISV +DLG+A NSL+A AGA Q+ ++NG+G +AG Sbjct: 177 DDAKKIVLEAKKRI----RKPISVTFSNDLGMATANSLSAAIAGADQIHVSVNGLGPKAG 232 Query: 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 LE+V++ + K + + T + + + S+ V +I +PI IVG F + + Sbjct: 233 IAPLEQVVVGL---KKLAGLDTNVKMELLPSVSEAVERISGIPISEISPIVGPLVFTYEA 289 Query: 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 G+H + +YEI++P +G + + + + SGR AVK + EMGY S+ +++ + Sbjct: 290 GVHVSAISNELSSYEIVSPGEVGRVR-RFWVGTHSGRKAVKEVLKEMGYSASDSDVERIL 348 Query: 358 DAFLKLADKKGQVFDYDLEALA--FIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACG 415 +L+ + ++ + ++ +G E P F++ + +GS TA ++ G Sbjct: 349 ARVKELSQEGIRITEAIFRSVVEEVLG---ERPRLFKVKEWVAVTGSGITPTATIRALIG 405 Query: 416 EEVKAEAANGNGPVDAVYQAINR---ITEYNVELVKYSLTAKGHGKDALGQVDIVANYNG 472 +++G GPVDA+ +AI I +N L ++ L A G +A+ ++ I Sbjct: 406 GREVISSSSGVGPVDAITKAIRSIQGIPSFN--LRRFRLIAVSSGSEAIAELKIRVVGPK 463 Query: 473 RRFHGVGLATDIVESSAKAMVHVLNNI 499 G + DIV++S KA+ +N I Sbjct: 464 GEVEAAGTSRDIVDASLKAIEEAVNKI 490 >UniRef50_C5QA64 2-isopropylmalate synthase n=1 Tax=Staphylococcus epidermidis BCM-HMP0060 RepID=C5QA64_STAEP Length = 390 Score = 192 bits (487), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 118/367 (32%), Positives = 202/367 (55%), Gaps = 7/367 (1%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ DTTLRDGEQA SL EKL++AL LE+ G++ +E GFP SS DF S Q I+ Sbjct: 6 RKITFLDTTLRDGEQAPGNSLKHGEKLELALMLEKAGIETIETGFPASSKEDFISTQKIS 65 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 + +K S +R +DID++ ++ +E + S +H+ K + + + IE Sbjct: 66 KILKTSNFATFSRTKLEDIDLSIQAGGTSEKHILMLVATGSDLHLEKKRKMSRQDGIEEI 125 Query: 123 IYMVKRARNY-TDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 V AR +V EDA R + ++ A+ +GA I + DT GY MP + Sbjct: 126 KKSVVYAREKGIKNVAVGIEDASRADSKYVEELINVAVQSGANQIILADTTGYAMPNDIY 185 Query: 182 GIISGLYERVPNIDKAI-ISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 ++ L +R I K+I +SVH H+DLGLAV NS A+ AGA +++G + GIGERAGN S Sbjct: 186 DLVK-LSKRC--ISKSIKLSVHCHNDLGLAVINSYYAILAGADEIQGTIGGIGERAGNTS 242 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 +E+V+ I + +++ +N + ++ + +S+ ++ I G F+ ++GIH Sbjct: 243 IEQVLALIHYKGKNKKIYSDVNKKNLYPIYEKLSEYIDLEENRTLPIFGKYVFSTAAGIH 302 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE-SEYNLDNLYDA 359 Q G+L + + YE + PE G + + + SG++ +K +++ + + +D+LY+ Sbjct: 303 QQGILNDPKTYEFVLPEDWGRTR-EFYIDKHSGKSILKDVVEKQNATDIVKDKIDSLYNK 361 Query: 360 FLKLADK 366 ++ D+ Sbjct: 362 YIDNNDR 368 >UniRef50_C7N750 Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Slackia heliotrinireducens DSM 20476 RepID=C7N750_SLAHD Length = 471 Score = 192 bits (487), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 143/500 (28%), Positives = 241/500 (48%), Gaps = 39/500 (7%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + V + D T+R E + +L+ KEKL+ A L+ +GV +E+ S D +++IA Sbjct: 2 RDVRVSDVTMRQAEVSGSLALTFKEKLETAKLLDSLGVSSIEIEGVERSKADALRIKSIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 VKNS + + +++I V +LK A R+ A SP + D +++ Sbjct: 62 SIVKNSVLAVPVKMDDENIQVVWGALKNAAFPRLQVVAAVSPARMEYVYHKKADGMMKDV 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + + TDDVEF +DA R L V++ AI AGA TI + D G +P EFA Sbjct: 122 AATIAKCAALTDDVEFVADDATRADSVYLRSVIKEAIQAGAKTITVCDDAGTMLPEEFAQ 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGA---MNGIGERAGNC 239 I L + +P + + + +DL +A ++A + +G +++ MN I Sbjct: 182 FIDDLRKDLPELADVALGISCSNDLFMADACAIAGIMSGVDEIKATTYPMNVI------- 234 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 SLE+V + + +I T + E+ RT+ V++IC Sbjct: 235 SLEKVCKVLAAKPEICQAQTTVRVTELKRTAAQVARICE--------------------- 273 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 + R Y P G ++ LT AV + ++GY+ SE + N+Y+A Sbjct: 274 ------QGRSKYSAFNPNVTGSDE-SFVLTVNDDIDAVMECVAKLGYELSEEDATNVYEA 326 Query: 360 FLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVK 419 FL++A KK V + +L+A+ Q P + L+ + + SG+ ATA V++ G+EV Sbjct: 327 FLRIASKKDSVSNLELDAIVASAALQ-VPATYVLENYVINSGNAIKATANVRMRKGDEVL 385 Query: 420 AEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVG 479 G+GP+DA + AI +I+ EL + + + G++A+GQ + +G+ + G G Sbjct: 386 EAVCIGDGPIDASFLAIEKISGKRYELDDWQMQSVTEGQEAMGQAIVKLVADGKIYSGRG 445 Query: 480 LATDIVESSAKAMVHVLNNI 499 ++TDIV SS +A V+ LN I Sbjct: 446 ISTDIVGSSIRAYVNALNKI 465 >UniRef50_D1J0N9 Whole genome shotgun sequence of line PN40024, scaffold_124.assembly12x (Fragment) n=1 Tax=Vitis vinifera RepID=D1J0N9_VITVI Length = 974 Score = 191 bits (486), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 113/263 (42%), Positives = 154/263 (58%), Gaps = 37/263 (14%) Query: 23 LSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSR--------VCALA 74 ++ KEKL IA L ++GVD++E GFP +S D ++V+ IA++V N+ +C LA Sbjct: 1 MTSKEKLDIARQLAKLGVDIIEAGFPAASKDDLDAVKIIAKEVGNAVDENGHVPVICGLA 60 Query: 75 RCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNY-T 133 RC DI A E A KL+ + EVIE A MVK AR+ Sbjct: 61 RCNRNDISTAWE---------------------AYKLKKSEKEVIEIAREMVKYARSLGC 99 Query: 134 DDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPN 193 DDVEFS EDAGR+ L +++ I AGATT+NIPDTVGYT+P EF +I+ + P Sbjct: 100 DDVEFSPEDAGRSEREFLYKILGEVIKAGATTLNIPDTVGYTVPNEFGQLIADIKSNTPG 159 Query: 194 IDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKD 253 I+ IIS H +DLGL+ N++A AGARQVE +NGIGERAGN SLEEV + ++ Sbjct: 160 IENVIISTHCQNDLGLSTANTIAGACAGARQVEVTINGIGERAGNASLEEVCLIYRLAPG 219 Query: 254 I-----LN--VHTAINHQEIWRT 269 + LN ++ ++N IWR+ Sbjct: 220 LCTDTQLNGVINLSMNLSGIWRS 242 Score = 157 bits (398), Expect = 7e-37, Method: Compositional matrix adjust. Identities = 101/277 (36%), Positives = 160/277 (57%), Gaps = 23/277 (8%) Query: 244 VIMAIKVR--KDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 V+MA+K R K + ++T IN + I +TS++V++ + + +KAIVG+ AFAH SGIHQ Sbjct: 680 VVMALKCRGEKALGGLYTGINIRHIVKTSKMVAEYSGLQVQPHKAIVGANAFAHESGIHQ 739 Query: 302 DGVLKNRENYEIMTPESIGL---NQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYD 358 DG+LK++E YEI++PE IGL N+ + L SGR A+K R+ E+GY+ LD+++ Sbjct: 740 DGMLKHKETYEIISPEDIGLFRSNESGIVLGKLSGRHALKSRLLELGYEIEGMELDDIFW 799 Query: 359 AFLKLADKKGQVFDYDLEALAFIGKQQEEPEHF-RLDYFSVQSGSNDIATAAVKLACGEE 417 F ++A+KK + D D+ +A + + +P+ F +L V G+ ++TA VKL + Sbjct: 800 RFKEVAEKKKNLTDVDV--IALVSDEIFQPKVFWKLGDLQVTCGTLGLSTATVKLIDADG 857 Query: 418 VKAEAAN-GNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIV----ANYN- 471 K A + G GPVD+ Y+AI+ + + V L++Y L A G DA+ ++ N+ Sbjct: 858 QKHVACSVGTGPVDSAYKAIDLLVKEQVTLLEYGLNAVTEGIDAIATTRVLIRGEKNHTL 917 Query: 472 ---------GRRFHGVGLATDIVESSAKAMVHVLNNI 499 R F G G DIV SS +A + LN + Sbjct: 918 TNALTGETVHRSFSGTGAGMDIVVSSVRAYISALNKM 954 >UniRef50_D1AJT6 2-isopropylmalate synthase/homocitrate synthase family protein n=4 Tax=Bacteria RepID=D1AJT6_SEBTE Length = 529 Score = 190 bits (483), Expect = 9e-47, Method: Compositional matrix adjust. Identities = 153/522 (29%), Positives = 267/522 (51%), Gaps = 46/522 (8%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 +V +FDTTLRDG QA S SVK+K+ + AL+ G+D +E G P S+P D E + + Sbjct: 3 KVEVFDTTLRDGAQARGISFSVKDKIAVTQALDAFGIDYIEAGNPGSNPKDLEFFELVKS 62 Query: 64 -QVKNSRVCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD-- 116 ++K+S++ A KD+ D SL A + F + H+ +++TL+ Sbjct: 63 VELKHSKLVAFGSTRRKDVAPEEDQNLISLLQAGTEYVSIFGKSWDFHVTDIIKTTLENN 122 Query: 117 -EVIERAIYMVK-RARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGY 174 E+I+ + +K + + D E + P L ++AA + GA + + DT G Sbjct: 123 LEMIKDTLLFLKSKGKKVIFDAEHFFDGYKNNPEYAL-EALKAAKDGGAEILTLCDTNGG 181 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 P E + I + E++ +I I +H H+D+G V NS+AAV AGA QV+G G GE Sbjct: 182 CFPEEISRITKEVKEKLGDIK---IGIHAHNDMGFGVANSIAAVEAGALQVQGTFLGYGE 238 Query: 235 RAGNCSLEEVIMAIKVRKDILNVHTAINHQE---IWRTSQLVSQICNMPIPANKAIVGSG 291 R GN +L +I ++++KD + + ++ + T++++++I N+ I + +G Sbjct: 239 RCGNANLSTIIANLQLKKD----YELVPREKLGLLTSTARIIAEISNITIEDSMPYIGKN 294 Query: 292 AFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVK---HRMDEMGYKE 348 AFAH G+H DGV K ++E + PE +G N+ + L+ SGR+ + R+D+ ++ Sbjct: 295 AFAHKGGMHIDGVSKASHSFEHINPELVG-NEREFLLSEVSGRSTILEEIRRVDKDIQRD 353 Query: 349 SEYNLDNLYDAFLKLADKKGQVFD-----YDLEALAFIGKQQEEPEHFRLDYFSVQS--- 400 SE + LK + +G F+ ++L ++GK + F L YF V+ Sbjct: 354 SEATAGII--ERLKELEYQGYQFEGAKATFELVIRKYLGKYK---PFFDLVYFDVKGNYI 408 Query: 401 GSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEY------NVELVKYSL-TA 453 G +TA VK+ ++++ A G+GPV+A+ QA+ E + L+ Y + Sbjct: 409 GKKYYSTAVVKVKVKDQIELTVAEGDGPVNALDQALRIALERFYPELKEMHLIDYKVRVL 468 Query: 454 KGHGKDALGQVDIVANYNGRR--FHGVGLATDIVESSAKAMV 493 KG +V ++ + + +G++TDI+E+S A+V Sbjct: 469 KGEENATASKVRVLIESADAKNSWTTIGVSTDIIEASWIALV 510 >UniRef50_A6LPH9 Homocitrate synthase n=10 Tax=Clostridia RepID=A6LPH9_CLOB8 Length = 389 Score = 190 bits (482), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 123/347 (35%), Positives = 188/347 (54%), Gaps = 21/347 (6%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 +++V I DTTLRDGEQ + +EK+ IA L +GVD +EVG P + ++++ I Sbjct: 9 NKKVSIVDTTLRDGEQTAGVVFANEEKIVIAEMLSDLGVDQLEVGIPTMGGDEKKAIKEI 68 Query: 62 ARQVKNSRVCALARCV----EKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 ++ + A R V E+ ID +++ ++ I+ S +HI KL+++ + Sbjct: 69 VKRNLKPSIMAWNRAVVSDIEQSIDCGVDAVAIS--------ISVSDIHIQHKLKTSREW 120 Query: 118 VIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMP 177 V+E + V+ A+ V + EDA R L + AA AGA DTVG P Sbjct: 121 VLESMVKSVEFAKKNGLYVSVNGEDASRADKDFLVEYINAAKQAGADRFRYCDTVGIMEP 180 Query: 178 FEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 F+ I +Y++ D I +HTHDD G+A N++A + GA V +NG+GERAG Sbjct: 181 FKIRDDIKYIYDKT-GFD---IEMHTHDDFGMATANAVAGIKGGASHVGVTVNGLGERAG 236 Query: 238 NCSLEEVIMAIKVRKDILNVH-TAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHS 296 N +LEEVIMA+ + + + IN Q SQ VS+ +P KAIVG+ FAH Sbjct: 237 NAALEEVIMALML---VYGYNGDGINTQMFREVSQYVSRASGRELPIWKAIVGTNMFAHE 293 Query: 297 SGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDE 343 SGIH DG +K+ +NYE P+ +GL + Q+ + SGRA++ ++ E Sbjct: 294 SGIHADGAIKDPKNYEAFDPDIVGLER-QIVIGKHSGRASIINKFRE 339 >UniRef50_A9HXK1 2-isopropylmalate synthase (Fragment) n=1 Tax=Roseobacter litoralis Och 149 RepID=A9HXK1_9RHOB Length = 250 Score = 189 bits (479), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 101/243 (41%), Positives = 148/243 (60%) Query: 255 LNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIM 314 L ++T IN + S +VS++ MP+ NKAI+G AFAHSSGIHQDG LK+RENYEIM Sbjct: 5 LGLNTNINAKHFSDISNMVSRMMRMPVQPNKAIIGQNAFAHSSGIHQDGFLKHRENYEIM 64 Query: 315 TPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYD 374 PE +G+N + LT+RSGR A+KH ++ +GY+ NLD +Y+ FL LAD+K + D D Sbjct: 65 NPEDVGINSADIILTARSGRHALKHHLERLGYEIERLNLDQVYERFLILADEKKAISDDD 124 Query: 375 LEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQ 434 + +L GK+ ++L V G TA++KL K A+GNGPV+A Sbjct: 125 IHSLMSDGKEDSYKNGYKLTLLQVLCGDPLSPTASIKLEHNGVEKEAMASGNGPVNATIN 184 Query: 435 AINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVH 494 AI I ++EL ++++ A G D + +V+I G+ + G G +TDIV++SA A + Sbjct: 185 AIQSIVGADIELKEFTIQAVNGGSDDVSKVNIRIASEGKSYVGHGFSTDIVKASAYAYLD 244 Query: 495 VLN 497 +N Sbjct: 245 AMN 247 >UniRef50_A0YSY8 2-isopropylmalate synthase n=1 Tax=Lyngbya sp. PCC 8106 RepID=A0YSY8_9CYAN Length = 271 Score = 183 bits (465), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 100/271 (36%), Positives = 159/271 (58%), Gaps = 9/271 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 ++IFDTTLRDGE S +K+QIA LE +GVD +E+G+P D + + +++ Sbjct: 7 ILIFDTTLRDGELTPGVHFSTPDKVQIAQQLEEIGVDTIEIGYPGRYAKDIDEIIAVSQV 66 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE--VIERA 122 +K S +CALA E +I+ AA+SL+ AE I+ + + T TLD+ ++ Sbjct: 67 IKGSTLCALAGSQETEINKAAKSLEKAEKSSINIYTLVN----LTSSSKTLDKNSILSTL 122 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + +A+NY + V+++ DA R I L V+ AI +GA I+IPD++G +P +F Sbjct: 123 KKQISQAKNYCNIVQWTAFDATRGDINFLCEAVQTAIESGAKIISIPDSLGVALPEDFYN 182 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 ++ LY+ +P + +SVH H+DLG AV NSL + G RQ+E A+NG+G R GN +L Sbjct: 183 LLQKLYQNIPQLQHVTVSVHCHNDLGKAVENSLVGLEVGVRQIECAVNGLGARKGNANLT 242 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLV 273 +V+ I+ + +T INH I + S+L+ Sbjct: 243 KVVNLIQSHH---SYYTTINHNLIPKISELI 270 >UniRef50_Q3A2Q7 Homocitrate synthase 1 n=18 Tax=Bacteria RepID=Q3A2Q7_PELCD Length = 400 Score = 182 bits (463), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 132/388 (34%), Positives = 196/388 (50%), Gaps = 19/388 (4%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 +II DTTLRDGEQ S++EK IA L+ +GV +E G P + SV+ + Sbjct: 9 IIIDDTTLRDGEQTAGVVFSLEEKKTIARMLDDIGVQELECGIPAMGREEQRSVKALVDL 68 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRST---LDEVIER 121 ++R+ R + DI + + A + ++ S +HI KLR + E ++R Sbjct: 69 GLHARLITWNRALVDDIRASLQCGVNA----VDISLSVSDLHIRHKLRKDRHWVREQLKR 124 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 A+ K+ Y V EDA R + L ++E A + GA DT+G PF Sbjct: 125 ALGFAKQHDLY---VSIGGEDASRADLDFLVELMELARSMGADRFRFCDTLGLLDPFVTF 181 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 I L +RV ++D I VHTH+DLG+A N++A V AGAR + +NG+GERAGN +L Sbjct: 182 EKIRYLTQRV-DLD---IEVHTHNDLGMATANAIAGVRAGARFINTTVNGLGERAGNAAL 237 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EEV+M + K V I+ S+ V N P+PA K +VG FAH SG+H Sbjct: 238 EEVVMGL---KHACGVKCPIDTSRFVEISRYVGAASNRPVPAWKPVVGERVFAHESGLHV 294 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 DGVLK+ NYE P +G +++ L L +GR + R+ +G + L L Sbjct: 295 DGVLKDPRNYEPFEPHEVGSSRL-LVLGKHTGRHGLAARVKGLGLDPGDICLSTLLRRIR 353 Query: 362 KLADKKGQ-VFDYDLEALAFIGKQQEEP 388 ++ ++ + V D +LE L Q +P Sbjct: 354 AISQRRKRPVEDAELEGLYRSLAQASQP 381 >UniRef50_Q2JTM1 Homocitrate synthase NifV n=7 Tax=Cyanobacteria RepID=Q2JTM1_SYNJA Length = 395 Score = 182 bits (462), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 120/349 (34%), Positives = 180/349 (51%), Gaps = 20/349 (5%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+ + I DTTLRDGEQA + + EK+ IA L+ +GV +EVG P + E+++ Sbjct: 1 MNSSITINDTTLRDGEQAAGVAFQIPEKISIAALLDAIGVPEIEVGIPAMGAVETEAIRA 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAES-LKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + + + R V DI + LK RIH + S IA K + ++ Sbjct: 61 MLSLGLRAHLLGWNRAVPSDILASIRCGLK-----RIHISVPVSDRQIAAKFQGDRPRLL 115 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE 179 + V+ A V EDA RT + + + + A + G DTVG PF Sbjct: 116 RQLRQCVEMALEQGLWVSVGAEDASRTSLEQVIELAQMAQSWGCRRFRYCDTVGVLDPFS 175 Query: 180 FAGIISGLYERVPNIDKAI---ISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERA 236 Y+++ + +AI + +HTHDDLG+A N+LA + AGA+ V +NG+GERA Sbjct: 176 T-------YKQIRRLVRAIDIPVEMHTHDDLGMATANALAGIRAGAQSVNTTVNGLGERA 228 Query: 237 GNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHS 296 GN LEEV+MA++ L + ++ + + SQ V++ P+P KAIVG AFAH Sbjct: 229 GNAPLEEVVMALRC---TLGIDVGVDTRRLRELSQQVARASGAPLPPWKAIVGDNAFAHE 285 Query: 297 SGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMG 345 SGIH GVL++ + YE PE++G +Q +L L SGR + + E G Sbjct: 286 SGIHAAGVLRDPQTYEPFPPEAVG-SQRRLVLGKHSGRHLLLQILKEHG 333 >UniRef50_Q6KZ01 2-isopropylmalate synthase n=1 Tax=Picrophilus torridus RepID=Q6KZ01_PICTO Length = 375 Score = 180 bits (457), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 125/377 (33%), Positives = 196/377 (51%), Gaps = 19/377 (5%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI----A 62 + D+TLR+GEQ S S+ +++IA AL GV ++E G P S +S+++I + Sbjct: 4 LLDSTLREGEQTPGVSFSMDARVEIARALSDAGVSMIEAGHPAVSETVLKSIKSIMELKS 63 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 + S + A +R V DIDVAA SL + I F S +H+ K T ++ I Sbjct: 64 SGIIRSTIVAHSRAVRSDIDVAA-SLNID---MIAIFYGISDLHLKYKTLKTREDAIRII 119 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + + AR+Y +V F+ EDA RT L V AA +AGA I+I DTVG P Sbjct: 120 VDSIDYARSYGLNVRFTAEDATRTDYNYLLDVARAARDAGAKRISIADTVGILNPDTSYK 179 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + + + V N++ +H H+DLG+AV NS+AA AGA + +NG+GER+G + Sbjct: 180 LFKMIIKDVKNVE---FDIHAHNDLGMAVANSIAAYRAGATIIHSTVNGLGERSGITPTQ 236 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 + A+K + I+ + ++ S LV + + +P N + G AF H SG+H Sbjct: 237 IIGPALKYHYN----EAVIDLKRLYSLSNLVEKYSGVMVPYNYPVTGKNAFTHKSGVHIA 292 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G++ E YE M P G N+ ++S SGR AV R+ E+G ++ +L L Sbjct: 293 GIINKPETYEFMDPCLFG-NKRYYTISSYSGRHAVITRLQELGISLNDEHLKILMKM--- 348 Query: 363 LADKKGQVFDYDLEALA 379 + +K ++ D +L A+A Sbjct: 349 IKNKNRELNDDELYAMA 365 >UniRef50_A6TTX4 Pyruvate carboxyltransferase n=1 Tax=Alkaliphilus metalliredigens QYMF RepID=A6TTX4_ALKMQ Length = 379 Score = 179 bits (455), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 116/341 (34%), Positives = 173/341 (50%), Gaps = 12/341 (3%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I DTTLRDGEQ KEK++IA L+ +GVD +E G P+ + + ++ I Sbjct: 6 IVDTTLRDGEQTPGVVFLKKEKIKIARMLDELGVDYIEAGIPIMGEEEKDVIREIIAMNG 65 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 +++ R + D+D SL + IH + S +HI KLR VI++ +V Sbjct: 66 KAKILTWNRMKKMDVDA---SLACGAKY-IHIAVPASDIHIFQKLRKDRKWVIQQVQEVV 121 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 V EDA R L + +AAI GA + DT+G P I Sbjct: 122 SYGAEKGCIVSVGAEDASRAEEKFLIEIYQAAIKEGAVRLRYADTLGILTPITTYQAI-- 179 Query: 187 LYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIM 246 +R+ + A + H H+D G+A NSL+A AGA+ ++ ++NG+GERAGN +LEE++M Sbjct: 180 --KRICDYIDADLEFHGHNDFGMATANSLSAFQAGAKYIDCSVNGLGERAGNTALEEIVM 237 Query: 247 AIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLK 306 +K +L + + I S +V + + +K IVG F+H SGIH DG+LK Sbjct: 238 TLKY---LLKSNHPFEIKRILELSNIVQEASRKIVGESKPIVGKSVFSHESGIHVDGLLK 294 Query: 307 NRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK 347 N YE +P IG + ++ L SGR V +R+ EMG K Sbjct: 295 NPTVYESFSPGEIGRKR-KIVLGKHSGRTTVIYRLQEMGIK 334 >UniRef50_B8FAB3 Pyruvate carboxyltransferase n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FAB3_DESAA Length = 374 Score = 179 bits (454), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 117/367 (31%), Positives = 188/367 (51%), Gaps = 11/367 (2%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V I DTTLRDGEQA + +EK+ +A+ L++ VD +EVG P P + ++ IA Sbjct: 7 VHIIDTTLRDGEQAPGVAFDKREKIALAMMLDQAHVDELEVGIPAMGPAAQDEIKAIAGL 66 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 + + A R ++ DID +SL + +H S +H+ + T V+ + Sbjct: 67 NPDCLLTAWCRALKDDID---QSL-LCNVTGVHISFPVSDIHLEA-MGKTRSWVLNQLSV 121 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 ++ A V +DA R +A L + V +A GA + I DTVG P + ++ Sbjct: 122 LIPYALQRFSRVSVGAQDAFRADMAFLEQFVHSANLRGAHRVRIADTVGLARPSQVENMV 181 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 L + K + H H+DLG+A N++AA+ AGA+ V +NG+GERAGN LE+V Sbjct: 182 HVLSKAA---GKMALEFHGHNDLGMATANTIAAIEAGAQAVSVTVNGLGERAGNAPLEQV 238 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 ++A + + T ++ + + + V++ N PIPA++ I G F H SGIH G+ Sbjct: 239 VVAAGT---LDSRSTCVDARRLSEICRYVAEAVNRPIPADQPITGQAVFTHESGIHCAGI 295 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 LKN + Y+ PE++G + QL + SG ++H + + G + E ++L A A Sbjct: 296 LKNPDTYQPFNPETVGRERAQLVIGRHSGSGMIRHVLAKAGVRLEEGKTESLMAAVRMEA 355 Query: 365 DKKGQVF 371 KK V Sbjct: 356 LKKRSVL 362 >UniRef50_Q02CM5 2-isopropylmalate synthase n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q02CM5_SOLUE Length = 536 Score = 178 bits (452), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 151/524 (28%), Positives = 258/524 (49%), Gaps = 51/524 (9%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESV-QTIA 62 ++ FDTTLRDG Q S SV +KL IA L+ +G+D +E G+P S+P D + ++ Sbjct: 2 KIFTFDTTLRDGTQGESISFSVDDKLIIAQKLDDLGIDYIEGGWPGSNPKDKDFFARSGE 61 Query: 63 RQVKNSRVCALARC------VEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 +K+S++ A VE+D +V A L A + F + +H+ L +L+ Sbjct: 62 LNLKHSKLTAFGSTRFAKNPVEEDRNVKA--LVEAGTPVVSIFGKSWDLHVRRALGISLE 119 Query: 117 E----VIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLA-RVVEAAINAGATTINIPDT 171 E + + Y+ R D E + G T D A R +EAA AGA+ + + DT Sbjct: 120 ENLVLISDTVGYIHGHGREVVYDAEHFFD--GYTADPDYALRTLEAAHKAGASVLCLCDT 177 Query: 172 VGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNG 231 G T+ I++ + +R II +HTH+D LAV N++AAV AGA V+G MNG Sbjct: 178 NGGTVTGRLVEIVAEVRKRF----DGIIGIHTHNDGDLAVANTIAAVEAGATHVQGCMNG 233 Query: 232 IGERAGNCSLEEVIMAIKVRKDILNVHTAINHQE---IWRTSQLVSQICNMPIPANKAIV 288 GER GN +L VI ++++ HT + ++ + T + ++++ N+P+ ++ V Sbjct: 234 YGERCGNANLASVIANLELKLG----HTTVGPEKLAGLSSTCRFIAELANLPLRNDQPFV 289 Query: 289 GSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE 348 G AFAH G+H VLK+ YE + PE++G N+ ++ ++ SGR + +++ + G + Sbjct: 290 GKSAFAHKGGVHVSAVLKDSATYEHIKPEAVG-NRQRVLVSDLSGRGNIIYKLKQHGLAD 348 Query: 349 S-EYNLDNLYDAFLKLADKKGQVFDYDLEAL-AFIGKQQEEPEHFRLDYFSVQS------ 400 E + + +K + +G Y+LEA E H + +F V+S Sbjct: 349 RLEEDTRRVLLERIKQMEYEG----YELEAAEGTFELLVREALHPGMHFFDVESYEVSTR 404 Query: 401 ---GSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITE------YNVELVKYSL 451 + +TA V L + V + G+GP DA+ + + +V L Y + Sbjct: 405 AAGNAASHSTATVTLKSQDGVHSATETGHGPFDALQVCLRKCLSKLYPQIVDVRLTDYKV 464 Query: 452 TAKGHGKDALGQVDIVANYNGRR--FHGVGLATDIVESSAKAMV 493 K V ++ ++ R + VG++ +++E+S KA+V Sbjct: 465 RVLDTNKGTAANVRVLIEWSDHRRSWSTVGVSDNVIEASWKALV 508 >UniRef50_B3DXX9 Homocitrate/citramalate synthase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DXX9_METI4 Length = 380 Score = 177 bits (450), Expect = 7e-43, Method: Compositional matrix adjust. Identities = 114/350 (32%), Positives = 173/350 (49%), Gaps = 12/350 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+ ++++ DTTLRDGEQA S ++K+QI L + G+ +E G P S + E+ Sbjct: 1 MNGKILLADTTLRDGEQAPGVFFSPRQKVQIVKLLAQCGIKEIEAGTPSSCKTEMEAFHK 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I R+ A R +D+ +++K + ++ I S + I+TKLR+ +V+E Sbjct: 61 ILSLGLKVRIVAWGRMTNEDL----QAVKSSRVSTVNLSIPLSDIQISTKLRTNRKQVLE 116 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 + V +AR +V ED+ R L +E A GA DTVG P Sbjct: 117 KIKEYVGKAREMGLEVALGGEDSSRAEENFLVEAIEVAKQEGAFRFRYADTVGILDPLCT 176 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 +S R+ + H HDD G+A NS+AA AG + + G+GERAGN + Sbjct: 177 YQTLS----RLKKWTSFPLEFHGHDDFGMATANSIAAWRAGVASISATLCGLGERAGNGA 232 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEE+ + +R+ NV I+ + ++ L S++ IP K+I+G F H SGIH Sbjct: 233 LEEIAFFLALRE---NVDVGIDLKGLFSLCLLTSRLSKRKIPPWKSIIGEEIFLHESGIH 289 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESE 350 DG+LKN NYE P IG + L SGR +V +++G SE Sbjct: 290 VDGILKNPRNYEPFNPSIIGRKH-RFTLGKHSGRKSVLWTYEKLGITLSE 338 >UniRef50_B4S9H2 Pyruvate carboxyltransferase n=13 Tax=Bacteria RepID=B4S9H2_PROA2 Length = 390 Score = 177 bits (449), Expect = 9e-43, Method: Compositional matrix adjust. Identities = 113/338 (33%), Positives = 177/338 (52%), Gaps = 14/338 (4%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + V I DTTLRDGEQA + + +EK IA L GV+ +E+G+P S + + IA Sbjct: 13 RPVWIIDTTLRDGEQAPGVAFTPEEKKTIAGKLAECGVNELEIGYPAISSEEQAVITEIA 72 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 R R+ + AR +DID A + +H S +++ +L E +E Sbjct: 73 RMQLPLRLTSWARAKWEDIDAAIR----CKTQGVHISFPLSELYL--QLMDKPYEWVEEQ 126 Query: 123 IYM-VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 +++ V +A+ Y D V +DA RT L R + A+ GA I I DTVG P Sbjct: 127 LHLLVPKAKKYFDFVSVGGQDATRTGPDILERFIREAVECGADRIRIADTVGIATPLHLM 186 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 +IS + + VP A + H H+DLG+A N+ +A+ AG V ++ G+GERAGN +L Sbjct: 187 QLISRIKKAVP----ATLEFHAHNDLGMATANAFSAMEAGCDAVSVSVTGLGERAGNAAL 242 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EE+ +A+K+ H++I + + +V++ N I K ++G+ F H SGIH Sbjct: 243 EELAIALKLSG---RYHSSIKTERLQELCGIVAKASNRNIEDQKPVIGASVFRHESGIHC 299 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKH 339 + +LKN +Y+ P IG + +L + SG AA++H Sbjct: 300 NALLKNPLSYQPFLPGEIGRDNYELVIGKHSGSAAIQH 337 >UniRef50_C6HVD7 2-isopropylmalate synthase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HVD7_9BACT Length = 392 Score = 175 bits (443), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 117/352 (33%), Positives = 177/352 (50%), Gaps = 14/352 (3%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 + DTTLRDG Q+ K+ + L R+GV +EVG P + E ++ + Sbjct: 13 VFVDTTLRDGGQSPGVFFDRPTKMAVVTTLSRIGVKEIEVGSPCLGEREHEDLKVLLSLP 72 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 + + R VE+D D A L++ R+H TS +H+A R +E ++R Sbjct: 73 VPAEIFPWLRPVEEDFDAA---LRLGFR-RVHISFPTSDLHMAVLRRVGREETLDRVRRA 128 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 V R V EDA R + L +++ +AG + DTVG P E + IS Sbjct: 129 VCRMVEEGCRVSVGLEDASRAEMGFLRDIIKTVQDAGGIRVRYCDTVGRHHPLEMSERIS 188 Query: 186 GLYE-RVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 L +P I VH H+DLGLA N++AA HAGA + + G+GERAGN ++EEV Sbjct: 189 ALASCGLP------IEVHCHNDLGLATANTVAAFHAGAAFLSTTVTGVGERAGNAAMEEV 242 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 A+ + T I+ + S+ + + + IVGS F HSSGIH DGV Sbjct: 243 AFALAFSGE--GGETGIDFPGLAHISRWLYTAIGRTLSPFRPIVGSRIFHHSSGIHVDGV 300 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNL 356 +K NYE+ PE +GL + ++ +T ++GRA +K+ ++ MGY+ + LD L Sbjct: 301 IKEPSNYELFPPELVGLKR-KIIVTHQTGRAGIKNVLERMGYRPTSEVLDRL 351 >UniRef50_C3NF24 2-isopropylmalate synthase/homocitrate synthase family protein n=19 Tax=Thermoprotei RepID=C3NF24_SULIN Length = 553 Score = 174 bits (440), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 146/520 (28%), Positives = 257/520 (49%), Gaps = 40/520 (7%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + V + DTTLRDG Q S ++ +K++IAL L+ +GV+ +E G+P S+P D E + I Sbjct: 31 KSVEVLDTTLRDGSQGANISFTLNDKIKIALLLDELGVEYIEGGWPGSNPKDEEFFKEIK 90 Query: 63 R-QVKNSRVCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRST--- 114 + ++ +R+ A KD+ D++ S+ A+ F + +H L+ T Sbjct: 91 KYKLSKARIAAFGSTKRKDVSVKEDISLNSIIKADVDFAVIFGKSWSLHATEVLKVTKQD 150 Query: 115 -LDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVG 173 LD + + Y+ D E + P L VV+ A +AGA I + DT G Sbjct: 151 NLDIIYDSINYLRSHGLKVIFDAEHFYQGFKEDPKYAL-EVVKTAESAGADVIALADTNG 209 Query: 174 YTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIG 233 T PFE I ++V + + +H H+D+G AV NSL A+ AGAR V+G +NGIG Sbjct: 210 GTPPFEVYEIT----KKVREVLHVKLGIHAHNDIGCAVANSLMAIKAGARHVQGTINGIG 265 Query: 234 ERAGNCSLEEVI--MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSG 291 ER GN L ++I + +K+ ++L ++ +++ S++V +I +P + VG Sbjct: 266 ERTGNADLIQIIPTLVLKMGFNVLKGRDSL--RKLREVSRIVYEILGLPPNPYQPYVGDN 323 Query: 292 AFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEY 351 AFAH +G+H D V+K YE + P +G N + ++ SG A + + +G + Sbjct: 324 AFAHKAGVHVDAVMKVPRAYEHVDPLLVG-NDRKFVISELSGTANLVSYLQGIGIVVDKK 382 Query: 352 NLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEE----PEHFRLDYFSVQSGSNDIAT 407 + + L A K+ + + + + +D+ + I +E + L+Y+ V + +N ++ Sbjct: 383 D-ERLKKALNKIKELETKGYSFDVGPASAILITLKELNMYTNYINLEYWKVINENNGLSI 441 Query: 408 AAVKLACGEEVKAEAANGNGPVDAVYQAIN--------RITEYNVELVKYSLTAKGHGKD 459 VK+ + E A G GPV+A+ +A+ I+E V+L+ Y + K+ Sbjct: 442 GIVKVNS----QLEVAEGVGPVNAIDRALRMALQRVYPEISE--VKLIDYRVILPSEVKN 495 Query: 460 ALGQVDIVANY--NGRRFHGVGLATDIVESSAKAMVHVLN 497 V + + N + G++ +VE+S A+V L+ Sbjct: 496 TESVVRVTIEFTDNKMNWRTEGVSKSVVEASVMALVDGLD 535 >UniRef50_Q04QM8 Isopropylmalate/homocitrate/citramalatesynthase n=15 Tax=Leptospira RepID=Q04QM8_LEPBJ Length = 435 Score = 174 bits (440), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 117/344 (34%), Positives = 188/344 (54%), Gaps = 19/344 (5%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 D TLRDG QAL+ + +K I L ++GV +EVGF S+ +F++ ++ Sbjct: 42 FFMDVTLRDGNQALRKPWDLDQKETIFKQLIKLGVQGIEVGFASSNSQEFKTCSRLSSIA 101 Query: 66 K-NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 N + +L+R VEK+I ++ ++++ A RIH S I L+ + ++V+E+ Sbjct: 102 PDNVVISSLSRAVEKEIKISWKAIRHASKPRIHIVYPISAFTIQNVLKLSPEKVLEKISE 161 Query: 125 MVKRARNYTD---DVEFSCEDAGRTPIADLARVVEA---AINAGATTINIPDTVGYTMPF 178 V A++ +++FS E G + + +L VEA A+N GA IN+P+TV P+ Sbjct: 162 SVSFAKSLVGSKGEIQFSGEHFGDS-LENLDFAVEAFRTALNYGADIINLPNTVERYRPW 220 Query: 179 EFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGN 238 F ++ + +P + A ISVHTH+DLG+A ++ + +GA Q+E A+NG+GERAGN Sbjct: 221 LFVSMVKAVRNVLP--ENAKISVHTHNDLGMATATTVESYFSGAVQLETALNGLGERAGN 278 Query: 239 CSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSG 298 + EV +A+ V +N I+ TS+LVS + N+PI +VG +H SG Sbjct: 279 TNTYEVAIALHN----CGVDVPLNLSAIYETSRLVSYLSNVPIYEKAPLVGEDVISHRSG 334 Query: 299 IHQDGVLKNRE----NYEIMTPESIG-LNQIQLNLTSRSGRAAV 337 I+QDGV K R Y IG + ++ TS+SGR+A+ Sbjct: 335 IYQDGVAKTRHLSKGAYRAFNATLIGRPEEDRIEFTSQSGRSAI 378 >UniRef50_UPI000038E0D5 2-isopropylmalate synthase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0D5 Length = 377 Score = 173 bits (439), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 117/352 (33%), Positives = 180/352 (51%), Gaps = 23/352 (6%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M +V I D+TLR+GEQ + ++++IA L V ++E G P+ SP + +++ Sbjct: 1 MPLKVGILDSTLREGEQTPGVLFNKNQRIEIAQLLSDAHVAMIEAGHPLVSPDIYSAIKE 60 Query: 61 I----ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 I A + NS + A +R V DID AA SL V RI F S +H+ K + Sbjct: 61 IMDMKASGMINSEIIAHSRAVNSDIDSAA-SLGVD---RIAIFYGVSDIHLDNKTHRSRT 116 Query: 117 EVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTM 176 E ++ + A + V F+ EDA RT I L VV A++AGA ++I DT+G Sbjct: 117 EALDIIYDSISYASSTGIPVRFTAEDASRTDINFLRNVVRTAVDAGADRVSIADTLGILT 176 Query: 177 PFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERA 236 P + A I + L +I H H+D+G+A+ N LAA +GA + +NG+GER Sbjct: 177 PEKTAYIFNNL----SDIKGVEYDFHGHNDMGMALANGLAAAESGATIIHSTVNGLGERV 232 Query: 237 GNCSLEEVIMAIKVRKDILNVHT---AINHQEIWRTSQLVSQICNMPIPANKAIVGSGAF 293 G I+ + +LN H AIN + S+L+ + + +P N + GS AF Sbjct: 233 G-------IIPTQALGVLLNYHLGVDAINLLSLKPLSELIEKYSGITMPPNYPVTGSTAF 285 Query: 294 AHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMG 345 H SG+H DG+++N YE M P +GL Q + SG+ A++ ++ MG Sbjct: 286 THKSGVHVDGIIRNPGTYEFMDPSRLGL-QHSFTIDKYSGKHALREKLANMG 336 >UniRef50_Q9V1J1 2-isopropylmalate synthase 2 n=5 Tax=Thermococcaceae RepID=LEU12_PYRAB Length = 361 Score = 172 bits (436), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 106/346 (30%), Positives = 182/346 (52%), Gaps = 20/346 (5%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 ++ D+TLR+GEQ + + +++L+IA+AL+ +GVD +E+G P S F ++ IA Q Sbjct: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 N + A +R + +DID LK + + F S + + R TLD +E+ Sbjct: 61 LNVELLAHSRALIEDIDYV---LKTGVDW-VGIFFCLSEACLRKRFRITLDHALEKISRA 116 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 ++ A+++ V F+ ED RT A+L R + A I++ DT G T P F ++ Sbjct: 117 IEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLV- 175 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245 +++ N ++VH H+DLGLA+ N++ + AGA V+ +NG+GERAG L ++I Sbjct: 176 ---KKIVNFGIP-VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQII 231 Query: 246 MAIKVRKDILNVHTAINHQE---IWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 +L H I ++R S LVS+I + N IVG AF H +G+H Sbjct: 232 T-------VLYYHYGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVS 284 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE 348 VLK+ YE + E G + + + +G+ +++ +++ G ++ Sbjct: 285 AVLKDPRFYEFLPAEVFGRER-TIYVDRYAGKDTIRYYLEKFGIRD 329 >UniRef50_Q44290 Homocitrate synthase 1 n=45 Tax=Bacteria RepID=NIFV1_ANASP Length = 377 Score = 172 bits (435), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 126/367 (34%), Positives = 181/367 (49%), Gaps = 18/367 (4%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 +V+I DTTLRDGEQA +++EK+ IA L+ +GV +EVG P + ++ I+ Sbjct: 3 KVLINDTTLRDGEQAAGVVFTLEEKVAIAKFLDTIGVPELEVGIPAMGEEEMRAICAISN 62 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAF-RIHTFIATSPMHIATKLRSTLDEVIERA 122 + + A R V DI + VA R+H I S + IA K ++R Sbjct: 63 LGLKANLLAWNRAVISDIKAS-----VACGMERVHIAIPVSGIQIAAKFHGQWRVSLQRL 117 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + A + V ED+ R L V A GA+ DTVG PF G Sbjct: 118 KDCISFAVDQGLWVAVGGEDSSRADENFLLDVALYAQEWGASRFRFCDTVGVLDPFTTYG 177 Query: 183 IISGLYE--RVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 + L +P + VHTH+D G+A N+LA + AGA V + G+GERAGN + Sbjct: 178 KVKLLVSALTIP------VEVHTHNDFGMATANALAGIKAGASSVNTTVIGLGERAGNAA 231 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV+MAI K I V I+ + SQLV+ +P KAIVG FAH SGIH Sbjct: 232 LEEVVMAI---KRIYGVDMGIDTPRLLELSQLVAAASGANVPPWKAIVGENTFAHESGIH 288 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 GVL+N + YE PE +G + +L + SGR +V + +++ G + ++ DA Sbjct: 289 AHGVLQNPDTYEPFAPEEVGWER-RLVVGKHSGRHSVSNLLEQHGIFLNPEETQSVLDAV 347 Query: 361 LKLADKK 367 + + KK Sbjct: 348 RQQSIKK 354 >UniRef50_A4A2P3 2-isopropylmalate synthase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A4A2P3_9PLAN Length = 542 Score = 171 bits (434), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 151/527 (28%), Positives = 252/527 (47%), Gaps = 50/527 (9%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGD---FESVQ 59 +++ I+DTTLRDG Q S S+++KL I L+ +GVD +E G+P+S+ D F VQ Sbjct: 2 RKIEIYDTTLRDGAQGEGVSFSLQDKLSITERLDEIGVDFVEGGYPLSNEKDAEYFRRVQ 61 Query: 60 TIARQVKNSRVCALARCVEKDIDVA----AESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + +K+++VCA K I+ A ++L + A + T H+ LR TL Sbjct: 62 DL--NLKHTKVCAFGMTRRKGINAADDPGMQALVSSGAPVVTIVGKTHDFHVTDVLRVTL 119 Query: 116 DE----VIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDT 171 +E + + Y+V R D E + P A + AA AGA + + DT Sbjct: 120 EENLAMIADSVAYIVGAGREVIYDAEHFFDGWKANP-EYAAETIRAAAKAGARMVVMCDT 178 Query: 172 VGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNG 231 G ++P E A + + + + +HTH+D LAV NSLAAV AGA QV+G +NG Sbjct: 179 NGGSLPEEIAEYAAKAIAALTEFN-VPVGIHTHNDGDLAVANSLAAVDAGAVQVQGTING 237 Query: 232 IGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSG 291 GER GN L VI + +++ V +Q + S+ V N+ N+A VG Sbjct: 238 FGERCGNADLISVIANLGLKRKGYEVIGGAGYQHLTELSRFVYDTANVNRRNNQAFVGQS 297 Query: 292 AFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAV-----KHRMD---- 342 AFAH G+H + + +YE + P+S+G N+ ++ ++ SGR+ + KH + Sbjct: 298 AFAHKGGMHVHAINRAASSYEHIDPQSVG-NERRVLVSELSGRSNIVALTTKHNLQDDRE 356 Query: 343 -------EMGYKESE-YNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLD 394 E+ KE++ + + +F L + VF+ E L + + ++ EH +D Sbjct: 357 LMDKILAEVVAKENQGFQFEAAEASFDLLVKRVAGVFEPHFEILKYHVEVEDLVEHKMVD 416 Query: 395 YFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINR------ITEYNVELVK 448 + A VK++ E++ E G+GPV A+ A+ + T + LV Sbjct: 417 L---------VTEATVKVSVDGEIRYEVGEGDGPVQALDVALRKSLNGCFPTLEEMHLVD 467 Query: 449 YSLTAKGH--GKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMV 493 Y + G A +V I + + +G++ +I+++S A+V Sbjct: 468 YKVRVVNQEAGTAARIRVTIESADENDVWGTIGVSENIIQASWNALV 514 >UniRef50_A8F3U8 2-isopropylmalate synthase n=1 Tax=Thermotoga lettingae TMO RepID=A8F3U8_THELT Length = 415 Score = 171 bits (433), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 123/364 (33%), Positives = 184/364 (50%), Gaps = 19/364 (5%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + +QVII D TLRDGEQ + EK+ IA L+++GV ++EVGFP S D + Sbjct: 34 LPEQVIIHDVTLRDGEQMAGVVFTEDEKVFIAQELDKIGVPMIEVGFPAVSGEDQRVFKR 93 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 +++ ++ ALAR +++D+ +AAE A+ T I +P + L E I+ Sbjct: 94 LSKMNLKAKKIALARIMDEDVKLAAEC--GADGLFYETSI--NPYFVKYVLGLDSKEFID 149 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVV--EAAINAGATTINIPDTVGYTMPF 178 R I K A+ VEF D R + + V E N I I DT G PF Sbjct: 150 RIIKGAKLAKELGLFVEFCGWDTFRINNLEWIKTVYTELLKNVEVDQIGISDTFGQAHPF 209 Query: 179 EFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGN 238 ++ + E P+I +S+H H+D GLA +L A+ +GA VE + N +GER GN Sbjct: 210 TVNFLVRKMKEWFPSIP---LSIHVHNDYGLATATALMAIASGAEAVETSFNCLGERTGN 266 Query: 239 CSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSG 298 S EEVI I++ IL + T ++ QE++R S+++ ++ M + NK IVG F SG Sbjct: 267 ASTEEVIAGIEM---ILGIKTNVDCQELYRVSKMIQEVSKMHVAPNKPIVGDRIFDSESG 323 Query: 299 IHQDGVLKNRENYEI------MTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYN 352 I D K EI PE+ G ++ +SGRA VK +D+ G K +E Sbjct: 324 IVIDANEKINRATEIKYAMYPYNPENFG-RWLKYVGGKKSGRAFVKQYLDKRGLKANEAQ 382 Query: 353 LDNL 356 +D + Sbjct: 383 IDEI 386 >UniRef50_A8ZTR1 2-isopropylmalate synthase/homocitrate synthase family protein n=3 Tax=Bacteria RepID=A8ZTR1_DESOH Length = 542 Score = 171 bits (433), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 153/528 (28%), Positives = 257/528 (48%), Gaps = 45/528 (8%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +QV I+DTTLRDG Q + +V EK+++A L+ +GV +E G+P S+P D + + A Sbjct: 2 EQVRIYDTTLRDGMQGDTINFTVDEKIRVARQLDDLGVHYIEGGWPGSNPRDVQFFEKAA 61 Query: 63 R-QVKNSRVCALAR------CVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + KN+R+ A VEKD ++ L A + T +HI + +TL Sbjct: 62 KIDFKNARLTAFGSTRRAGLAVEKDDNI--RLLLECGAPAVALVGKTWDLHITEVMSNTL 119 Query: 116 DEVIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTV 172 + +E V +++ +V F E D + + A AGA + + DT Sbjct: 120 ESNLEMIHDSVAYVKSHGREVFFDAEHFFDGCTHNREYTFKAILTAAQAGADAVILCDTN 179 Query: 173 GYTMPFEF----AGIISGLYERVPNIDKAI---ISVHTHDDLGLAVGNSLAAVHAGARQV 225 G +P + A + + L +R P D + +HTH+D LAV NS+AA+ AGAR V Sbjct: 180 GGALPHDVEAITAEVCTTLADRFPGPDGGSTVQVGIHTHNDSNLAVANSIAAIRAGARIV 239 Query: 226 EGAMNGIGERAGNCSLEEV--IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 +G +NG GER GN L + I+A K+ D + T N +++ + S+ VS+ NM Sbjct: 240 QGTINGYGERCGNADLTSIIPILAAKMEYDCI---TPENLKKLRKVSRFVSETANMTPVN 296 Query: 284 NKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDE 343 ++ VG AF+H G+H ++KN YE M PE +G N+ ++ ++ SGR+ V ++ E Sbjct: 297 SRPFVGKSAFSHKGGLHVSAIMKNPRAYEHMDPELVG-NKRRVLISDLSGRSNVTYKARE 355 Query: 344 MGYKES--EYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQE--EPEHFRLDYFSV- 398 +G +++D + +K+ + +G FD + + ++ F L F V Sbjct: 356 LGINTDTEHFDVDRILSE-VKMLELEGFQFDAADGSFKIVMEKISGLYTPLFDLLSFRVT 414 Query: 399 ---QSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINR-ITEY--------NVEL 446 + A A ++L GE AA G+GPV A+ A+ I E+ ++L Sbjct: 415 VEKEKDRPCTAHATIRLGVGELETTTAAEGDGPVSALDTALRMAIAEFYPDSLGLDAMQL 474 Query: 447 VKYSLTAKG--HGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAM 492 V + + G A +V I + + +G++ DI+E+S +A+ Sbjct: 475 VDFKVRVLDGRDGTSAKVRVLIDSRDEDEVWGTIGVSEDIIEASWEAL 522 >UniRef50_B9KY22 2-isopropylmalate synthase/homocitrate synthase family protein n=4 Tax=Bacteria RepID=B9KY22_THERP Length = 562 Score = 171 bits (432), Expect = 8e-41, Method: Compositional matrix adjust. Identities = 157/523 (30%), Positives = 253/523 (48%), Gaps = 41/523 (7%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGD---FESVQ 59 ++V+I+DTTLRDG Q SL+ ++KL+IA AL+ +GV +E G+P S+P D FE + Sbjct: 30 RRVVIYDTTLRDGTQGSGVSLTTEDKLKIARALDELGVAYIEGGWPGSNPKDMAFFERAR 89 Query: 60 TIARQVKNSRVCALARC------VEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRS 113 +Q +++R+ A VE+D+++ L AE + SP + L + Sbjct: 90 H--QQWRHARITAFGSTRRAGGTVEEDVNL--RLLLEAETPAVTIVGKASPFQVRVILGT 145 Query: 114 TLDE----VIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIP 169 TLDE V E ++ R D E + P LA V+ AA +AGA + + Sbjct: 146 TLDENLRMVAESVAFLKAAGREVIFDAEHFFDGYAEDPDYALA-VLRAACDAGADAVVLC 204 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT G T+ + V + +HTH+D LAV N++AAV AGA V+G M Sbjct: 205 DTNGGTLTDPLVRAVRHALSSV----SCTVGIHTHNDCELAVANTIAAVLAGAMHVQGTM 260 Query: 230 NGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVG 289 NG+GER GN +L +I ++ + + N +++ TS+ V+++ N+ VG Sbjct: 261 NGLGERIGNANLCSIIPILEYKLGYRCLPPG-NLRKLTETSRYVAEVANLAHDPRLPFVG 319 Query: 290 SGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRA--AVKHRMDEMGYK 347 + AF H +G+H + + K+ YE + PE +G N + ++ SGR+ VK R + Sbjct: 320 AFAFTHKAGLHVNAIAKHPSAYEHIPPEVVG-NTRHVLVSELSGRSNIVVKARSFGIELG 378 Query: 348 ESEYNLDNLYDAFLKLADKKGQVF---DYDLEALAFIGKQQEEPEHFRLDYFSV---QSG 401 + + + + +L + G F D LE L P LDY + ++G Sbjct: 379 DKPEVVRRVLEQIKEL-EFHGYWFEDADASLELLIRRNLPDYRPPFEVLDYTVLTEYRNG 437 Query: 402 SNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINR--------ITEYNVELVKYSLTA 453 +A A VKL G+ V AA GNGPV+A+ +A + I ++E K + Sbjct: 438 RGMLAEAMVKLRIGQHVFHTAAEGNGPVNALDRATRKALQEFYPEIAAVDLEDYKVRVLD 497 Query: 454 KGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVL 496 HG A +V I + ++ VG + +I+E+S A+ L Sbjct: 498 DHHGTGAKVRVWIRSGDAHGSWNTVGSSENIIEASWLALADSL 540 >UniRef50_B8I2I3 Pyruvate carboxyltransferase n=1 Tax=Clostridium cellulolyticum H10 RepID=B8I2I3_CLOCE Length = 388 Score = 170 bits (431), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 110/353 (31%), Positives = 186/353 (52%), Gaps = 16/353 (4%) Query: 9 DTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNS 68 DTTLRDGEQ + ++K++IA L++ G++ ++ GF +S + S++ I Sbjct: 21 DTTLRDGEQVSGIRYTPEQKVEIAQMLDKAGIESIDAGFAATSEEERLSIRKICDLGLKM 80 Query: 69 RVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL----DEVIERAIY 124 R+ ++ R + +DID A+ S V FI S +H+ K + ++++A+ Sbjct: 81 RIMSMCRVIREDIDFAS-SCGVEGVI---LFIPGSDIHLKAKFGEDIPAVRKNIVQKAMD 136 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 +K A++ VEF ED+ RT L ++ A GA + DT+GY P I Sbjct: 137 AIKYAKDKGLFVEFGVEDSTRTDFNVLLEILSQAEQEGADILGTTDTIGYLTPERTYNFI 196 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 L V N+ K I VH H+D+GLA N++A + AG +NG+GERAGN SLEEV Sbjct: 197 KKL---VRNL-KLPIGVHCHNDMGLATANTIAGLLAGGGYCSPTVNGMGERAGNASLEEV 252 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 IM +KV + N + + + S+ V + + + K IVG A++H SGIH G+ Sbjct: 253 IMILKV---LYNQDLKYDTKILGELSKTVEKYSGISMDIFKPIVGQNAYSHESGIHVHGM 309 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 LK+ YE+ P+ +G ++ + + +G+ ++H + G++ SE +++ + Sbjct: 310 LKDINTYELFDPQLVGHSR-KYEMGKHAGKHTIQHILKTNGFELSEEEVEDFW 361 >UniRef50_C1SID8 Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SID8_9BACT Length = 376 Score = 170 bits (431), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 120/368 (32%), Positives = 182/368 (49%), Gaps = 12/368 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 +II DTTLRDGEQ + S KEKL I L+ +GV +E G PV + ++I Sbjct: 1 MIIDDTTLRDGEQTPGVAFSRKEKLTIVKHLDAIGVQEIEAGIPVMGLAESRMFESIMEL 60 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 ++R+ A R + D+ + A A I + S + I TKL T ++++ Sbjct: 61 GLDARIIAWNRALIGDVQASI----AAGANSIEISLPMSDVQINTKLNKTRGWILDQVKS 116 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 ++ N+ + EDA R LA + GA DTVG PF+ + Sbjct: 117 VLDFCANHDLYISVGGEDASRADFDFLAEYIRTIEAHGADRFRFCDTVGILDPFKTYELT 176 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + + E + ++D I +HTH+D G+A N+LAAV AGA V + G+GERAGN LEE+ Sbjct: 177 AKIRE-ITSMD---IEIHTHNDFGMATANALAAVRAGATHVNTTVIGLGERAGNAPLEEI 232 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 IMA + + + A + + + S+ V+Q + + ++G F H SGIH DGV Sbjct: 233 IMA---SRHVYGMDDAFDTKTMRSLSEYVAQAAGRNLDPQRPVIGEFMFTHESGIHTDGV 289 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 LKN +NYE P + + Q L ++SG A +K+ +++ G Y L L KLA Sbjct: 290 LKNPKNYEAFDPAELNM-QRNLVFGNQSGLAVLKYILEQEGIVLESYQLTGLLHEAKKLA 348 Query: 365 DKKGQVFD 372 K V + Sbjct: 349 RKNKAVLN 356 >UniRef50_B2UP78 2-isopropylmalate synthase/homocitrate synthase family protein n=2 Tax=Bacteria RepID=B2UP78_AKKM8 Length = 544 Score = 169 bits (429), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 142/477 (29%), Positives = 237/477 (49%), Gaps = 37/477 (7%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 MS ++ ++DTTLRDG Q+ +LS +K++IA L+ +G+D +E G+P ++P + E Sbjct: 1 MSTKIFLYDTTLRDGAQSEDVNLSATDKVRIARQLDYLGMDYIEGGWPGANPVETEFFNA 60 Query: 61 I-ARQVKNSRVCALARCVEK----DIDVAAESLKVAEAFRIHTFIATSPMHIATKL---R 112 + ++N+++ A + D +L + A F + P H+ L R Sbjct: 61 MRGVGLRNAKLAAFGSTHHPSHTPETDPTLTALISSGARVAAVFGKSCPRHVEVALGISR 120 Query: 113 STLDEVIERAI-YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDT 171 E+I +I ++ K D E + R LA V+ A GA + + DT Sbjct: 121 ERNLEIIGNSISFLKKNMEEAFFDAEHFFDGFKRDQEYALA-VLRTAWEHGADCLVLCDT 179 Query: 172 VGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNG 231 G TMP E + II + ER+P+ A++ +H H+D LAV NSLAAV++GA QV+G +NG Sbjct: 180 NGGTMPEEISSIIRTVRERLPH---ALLGIHAHNDCELAVANSLAAVNSGAIQVQGTVNG 236 Query: 232 IGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSG 291 IGER GN +L VI ++V+ + + + + T+ VS++ N+ + VG+ Sbjct: 237 IGERCGNANLCSVIPNLQVKMKGFSCLSGASLTRLKSTAAFVSEVSNLAPFRRQPFVGNA 296 Query: 292 AFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEY 351 AFAH G+H ++K YE + P +G N ++ +T + GR+ + +G++ + Sbjct: 297 AFAHKGGVHVSAIMKEAALYEHIDPSLVG-NAQRVLMTEQGGRSNILSLSRTLGFELEKG 355 Query: 352 NLDNLYDAFLKLADKKGQVFDYDLEA------LAFIGKQQEEPEHFRLDYFSV------- 398 D L D L A KK YD A L F+ + P++ YF++ Sbjct: 356 --DPLLDV-LSAAVKKNAALGYDYVAAPASAELLFL---RHMPDNALKPYFNILRTVVLT 409 Query: 399 ---QSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINR-ITEYNVELVKYSL 451 + + + A++KL V+ AA G GPV A+ +A+ R +T + EL + L Sbjct: 410 SRHEMDPDMMVEASLKLDVHGNVEHTAAGGFGPVHALDRALRRALTRWYPELEQMHL 466 >UniRef50_UPI0001B425AC 2-isopropylmalate synthase n=1 Tax=Listeria monocytogenes FSL J1-208 RepID=UPI0001B425AC Length = 258 Score = 169 bits (428), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 94/241 (39%), Positives = 145/241 (60%), Gaps = 9/241 (3%) Query: 259 TAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPES 318 T I + +S L+S++ MP+P NKA++G A+AH SGIHQDGVLKN + YEI+TP Sbjct: 4 TNIVLNQFKNSSDLISRLSGMPVPRNKAVIGGNAYAHESGIHQDGVLKNPDTYEIITPAL 63 Query: 319 IGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEAL 378 +G+++ L L SG+ A RM+E+GY SE L + + F +LAD K +V + DL AL Sbjct: 64 VGVDKNSLPLGKLSGKHAFLTRMEEIGYTLSEKELKDAFKRFKQLADAKKEVTEDDLHAL 123 Query: 379 AFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA----EAANGNGPVDAVYQ 434 +G+ E + F L + VQ + + A V++ EE +AA G+G ++A+Y Sbjct: 124 -ILGQSSESADDFELKHLQVQYVTGGVQGAIVRI---EERNGALIEDAATGSGSIEAIYN 179 Query: 435 AINRITEYNVELVKYSLTAKGHGKDALGQVDIV-ANYNGRRFHGVGLATDIVESSAKAMV 493 INR+ + ++EL Y + A G+DA +V +V + NG FHG+G+ D++ +SAKA + Sbjct: 180 TINRLMKQDIELTDYRIQAITAGQDAQAEVHVVIKDNNGTEFHGIGIDFDVLTASAKAYL 239 Query: 494 H 494 Sbjct: 240 Q 240 >UniRef50_A7IBL6 Homocitrate synthase n=19 Tax=Proteobacteria RepID=A7IBL6_XANP2 Length = 415 Score = 168 bits (426), Expect = 4e-40, Method: Compositional matrix adjust. Identities = 123/349 (35%), Positives = 174/349 (49%), Gaps = 12/349 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 ++ + DTTLRDGEQA + + +EK++IA AL GV +E G P + E++++I Sbjct: 30 ARTAFLNDTTLRDGEQAPGVAFTRREKIEIAEALAAAGVPEIEAGTPAMGDEEIETLRSI 89 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 RV A R E+D+ AA S V ++ I TS + KL D + Sbjct: 90 VSLKLPLRVAAWCRMSEEDL-FAAVSAGVTY---VNLSIPTSDRQLKGKLNRDRDWALGA 145 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 ++V A CEDA R L +V E A AGA + + DT+G PF Sbjct: 146 LRHVVTLATKLGFTAAVGCEDASRADPDFLCKVAEVAKEAGAFRLRLADTLGVLDPFSAY 205 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 ++ RV N I H HDDLGLA N+LAAV GAR + G+GERAGN +L Sbjct: 206 ALV----RRVANATDLEIEFHAHDDLGLATANTLAAVTGGARHASVTVAGLGERAGNAAL 261 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EEV +A+ + T I+ + +Q V + P+P KAIVG F H SGIH Sbjct: 262 EEVAIAL---RQTARSETGIDPHALRPLAQKVMEAAGRPMPRTKAIVGEDIFTHESGIHV 318 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESE 350 G+LK+R YE ++PE +G + ++ L SG AA+ + + G E Sbjct: 319 SGLLKDRGTYEALSPEMLGRSH-RVVLGKHSGLAAILKALSDQGLAVDE 366 >UniRef50_D2LHQ1 Homocitrate synthase n=1 Tax=Rhodomicrobium vannielii ATCC 17100 RepID=D2LHQ1_RHOVA Length = 427 Score = 168 bits (425), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 132/381 (34%), Positives = 188/381 (49%), Gaps = 15/381 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +S +V I DTTLRDGEQ + + EK+QIA AL +GVD +EVG P + E+++ Sbjct: 30 LSGRVAINDTTLRDGEQTPGVAFTAAEKMQIAAALADVGVDEIEVGTPAMGRDEQEAIRR 89 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIA-TSPMHIATKLRSTLDEVI 119 IA+ RV A R D+D A +A I A S IA K +L V+ Sbjct: 90 IAKAGLPLRVIAWCRMRRGDVDDA-----IASGVSIVNLSAPVSRFQIAAKFGGSLPRVV 144 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE 179 ++ AR +V F ED+ R L ++EAA AGA DT+G P Sbjct: 145 AAVTDVIGYARAKGLEVAFGGEDSSRATRDTLEPILEAAARAGAVRYRFADTLGVLDPIS 204 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 I E V I I H HDDLGLA N+LAA+ AGA +NG+GERAGN Sbjct: 205 IRAAI----EAVRRITDLPIEFHGHDDLGLATANTLAALEAGASAASVTVNGLGERAGNA 260 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 LE++ +A+ + T I+ + S+LV++ I + IVG F H SGI Sbjct: 261 PLEQIAVAL---DSLFAQATRIHLPALGHLSELVARCSGREIARSAPIVGKDVFTHESGI 317 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 H DG+LK+++ YE ++P +G N + + SG A ++H + +G + +E L A Sbjct: 318 HVDGILKSKDCYEALSPRRLGRNH-RFVVGKHSGLAGLRHELSYLGLQLTEDEERRLLAA 376 Query: 360 FLKLADK-KGQVFDYDLEALA 379 A+K K + + L LA Sbjct: 377 VRGYAEKHKACIPSFTLLRLA 397 >UniRef50_A5VPL4 2-isopropylmalate synthase/homocitrate synthase family protein n=151 Tax=Bacteria RepID=A5VPL4_BRUO2 Length = 640 Score = 167 bits (424), Expect = 7e-40, Method: Compositional matrix adjust. Identities = 153/529 (28%), Positives = 253/529 (47%), Gaps = 45/529 (8%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ I+DTTLRDG+Q SV++K I LE +GVD +E G+P ++P D + Sbjct: 107 ERIYIYDTTLRDGQQTPGVDFSVEDKKSIVTLLEELGVDYVEGGYPGANPTDTAFFKR-- 164 Query: 63 RQVKNSRVCALARCVEKDIDVAAE----SLKVAEAFRIHTFIATS-PMHIATKLRSTLDE 117 RQ ++ A + V+ + SL A A + F+A S H+ L T +E Sbjct: 165 RQTARAKFVAFGMTKRAGVSVSNDPGLSSLLQASADAV-CFVAKSWDYHVRLALGCTNEE 223 Query: 118 VIERAIYMVKRARNYTDDVEFSCE---DAGRT-PIADLARVVEAAINAGATTINIPDTVG 173 +E V AR + CE D + P LA +AA +AGA + + DT G Sbjct: 224 NLESITASVTAARMAGREALVDCEHFFDGYKANPEYALA-CAKAAYSAGARWVVLCDTNG 282 Query: 174 YTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIG 233 T P E A I+ + VP + +H H+D AV SLAA+ AG R V+G +NGIG Sbjct: 283 GTQPLEVAAIVEAVKAVVPGES---LGIHAHNDTEQAVAVSLAAIDAGVRHVQGTLNGIG 339 Query: 234 ERAGNCSLEEVIMAIKVRKDI-----LNVHTAINHQEIWRTSQLVSQICNMPIPANKAIV 288 ER GN +L +I + ++ L + A + + I R S+ I N P Sbjct: 340 ERCGNANLVSLIPTLVLKPYWAERFELGIKPA-SLKSITRISRAFDDILNRPATEQAPYT 398 Query: 289 GSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK- 347 G+ AFA +GIH ++K + YE + PES+G N ++ ++ + G++ ++ G + Sbjct: 399 GTSAFATKAGIHASALMKEPQTYEHIPPESVG-NSRRVMVSDQGGKSNFIAELERRGIRV 457 Query: 348 -ESEYNLDNLYDAFLKLADKKGQVF---DYDLEALAFIGKQQEEPEHFRLD--------Y 395 + + LD L A +K + +G + D E LA G +PE F+++ Sbjct: 458 AKDDVRLDTLI-ALVKEREAEGYAYEGADASFELLAR-GMLNPQPEFFKVESFRCLVERR 515 Query: 396 FSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEY------NVELVKY 449 F ++ A VK+ E+ A G+GPV+A+ A+ + ++ELV + Sbjct: 516 FDANGMLKTVSEAVVKVEVDGEMHMSVAEGHGPVNALDIALRKDLGCFQAEIEDLELVDF 575 Query: 450 SLTAKGHGKDALGQVDI-VANYNGRRFHGVGLATDIVESSAKAMVHVLN 497 + G A+ +V I + G R+ VG++ +I+++S +A++ +N Sbjct: 576 KVRILNGGTAAITRVLIESGDATGARWRTVGVSDNIIDASFQALMDSVN 624 >UniRef50_B0TW82 2-isopropylmalate synthase n=17 Tax=Francisella RepID=B0TW82_FRAP2 Length = 526 Score = 167 bits (422), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 127/370 (34%), Positives = 192/370 (51%), Gaps = 33/370 (8%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ IFDTTLRDG+Q+ A +S ++ + A ++ +DV+E GFP +S DFE V TI+ Sbjct: 4 KKIYIFDTTLRDGQQSPGAGMSFEDNIAYADLANKLNIDVLEAGFPSASNTDFEIVNTIS 63 Query: 63 RQV--KNSRVCALARC------VEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRST 114 +++ KNS + C VE +D SL + +A R+H ++ P L S Sbjct: 64 KRMAEKNSNMIIAGLCQLRKNQVEITMDALRPSLAIGKA-RVHMYLPVDPNLAQASLGSK 122 Query: 115 LD--EVIERAIYMVKRARNYTDDVEFSCEDAGRTPIAD----LARVVEAAINAGATTINI 168 D + I+ ++K A + +VEFS E G + + D + V AA++AG T IN Sbjct: 123 NDNEQNIKNVYELIKLASDQGFEVEFSAE--GYSRLGDTFDYVTDVFRAAVSAGVTVINC 180 Query: 169 PDTVGYTMPFE----FAGIISGLYERVPN--IDKAII-SVHTHDDLGLAVGNSLAAVHAG 221 PDT+G E F ++ E + DK II S H H+DLGLA+ NS+ AV G Sbjct: 181 PDTIGGACERENDNYFVKNMTKHAEIIKKEFPDKNIIWSAHCHNDLGLALENSMNAVFDG 240 Query: 222 -ARQVEGAMNGIGERAGNCSLEEVIMAIKV--RKDILNVHTAINHQEIWRTSQLVSQ--I 276 A QVEG +NG+GERAGN SLE+ +M I + ++ + + IN S + + + Sbjct: 241 PATQVEGCINGVGERAGNASLEQCVMFINLFGKQKDCHFYNDINIANFKTISDFIGKRML 300 Query: 277 CNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAA 336 P + I G + H+SG H + +L N Y+ PES+G N+I SG Sbjct: 301 SRQP---HHPITGLNSARHTSGGHTNAILNNPLAYQPFHPESVG-NEISFIFGPLSGGNH 356 Query: 337 VKHRMDEMGY 346 K ++E GY Sbjct: 357 AKKIIEENGY 366 >UniRef50_C6VV54 Pyruvate carboxyltransferase n=32 Tax=Bacteria RepID=C6VV54_DYAFD Length = 520 Score = 166 bits (421), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 147/510 (28%), Positives = 236/510 (46%), Gaps = 19/510 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQT 60 S+ + I DTTLRDGEQ S S EKL IA + L+ + VD +EV S G+F++V+ Sbjct: 3 SRYIEIMDTTLRDGEQTSGVSFSASEKLTIAQILLQEVKVDRIEVASARVSEGEFQAVKK 62 Query: 61 IARQV-KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 I N + + D D + + A A ++ S H+ +L+ + + Sbjct: 63 ITDWAGANGFLDKIEVLTFVDGDASINWMVQAGARVMNLLTKGSLNHLTHQLKKSPEAHF 122 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTVGYTM 176 E +V+ A ED R+ + + ++ I +PDT+G Sbjct: 123 EDIRNVVELAEKNGIQCNVYLEDWSNGMRSSKEYVFQSLDFLSTLPVKRILLPDTLGILT 182 Query: 177 PFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERA 236 PFE I + +R P+ H H+D L V N + A+ AG + + +NG+GER Sbjct: 183 PFESYTFIKEIVDRYPD---QHFEFHGHNDYDLGVANVMEALRAGVQGLHLTVNGMGERT 239 Query: 237 GNCSLEEVIMAIKVRKDIL-NVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAH 295 GN L I I D++ TA+N + ++ S+LV + IPANK IVG F Sbjct: 240 GNAPLASTIAVIN---DLMPECTTAVNEKSLYSISKLVETFSGIRIPANKPIVGESVFTQ 296 Query: 296 SSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDN 355 ++GIH DG KN + + PE G ++ L SG+A +++ + ++G S+ +L Sbjct: 297 TAGIHADGDKKNNLYFSKLMPERFGRQRL-YALGKTSGKANIENNLRDLGISLSDADLKK 355 Query: 356 LYDAFLKLADKKGQVFDYDLE-ALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLAC 414 + ++L D+K V DL ++ I E + + + N +A ++++ Sbjct: 356 VTQRIIELGDRKEVVTPEDLPYIISDILDSDAIEEKVVITNYVLTHSKNLKPSATLQISF 415 Query: 415 GEEVKAEAANGNGPVDAVYQAINRI-TEYNVE---LVKYSLTAKGHGK-DALGQVDIVAN 469 GEEV E A G+G DA A+ +I + +E L Y++ GK DAL + I Sbjct: 416 GEEVFEENAQGDGQYDAFMNALKKIYKKKGIELPMLSDYTVRIPPGGKTDALCETIITWE 475 Query: 470 YNGRRFHGVGLATDIVESSAKAMVHVLNNI 499 NG+ GL +D S+ KA +LN I Sbjct: 476 INGKEIKTRGLDSDQTFSAIKATQKMLNLI 505 >UniRef50_C0AC93 Trans-homoaconitate synthase n=2 Tax=Opitutaceae bacterium TAV2 RepID=C0AC93_9BACT Length = 397 Score = 163 bits (413), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 116/322 (36%), Positives = 163/322 (50%), Gaps = 26/322 (8%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 + DTTLRDGEQA S +KL IA AL V +EVG P + G + + +A V Sbjct: 11 LIDTTLRDGEQAAGVVFSQADKLAIARALVEARVPELEVGIPAAGAGAIDDINAVADAVA 70 Query: 67 N-SRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHI-------ATKLRSTLDEV 118 +R+ R + DI +A + +H S +H+ AT L ++LDE Sbjct: 71 GRARIITWCRALPGDIALA----RACRVTGVHLSFPVSNIHMRIWGATPATVL-ASLDE- 124 Query: 119 IERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 + AR + D V +DA R LA AA A + + DTVG+ P Sbjct: 125 ------LTAAAREHFDQVTVGAQDASRADPGFLAEFAAAAARTPAVRLRLADTVGFLTPD 178 Query: 179 EFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGN 238 + AG+ S L P + + +H H+DLGLA N+LAA AGA +NG+GERAGN Sbjct: 179 KTAGLTSHLRHAAPALP---VEIHAHNDLGLATANTLAAFSAGASAASLTVNGLGERAGN 235 Query: 239 CSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSG 298 +LEEV+MA+KV + I I+ S LV++ P+P K +VG+GAF H SG Sbjct: 236 AALEEVVMALKVAQGI---DCGIDTSRFVELSALVARASRRPVPVQKPVVGAGAFLHESG 292 Query: 299 IHQDGVLKNRENYEIMTPESIG 320 IH G+L++R +YE P +G Sbjct: 293 IHCAGLLRDRRSYEPFDPADVG 314 >UniRef50_A9A1L0 Pyruvate carboxyltransferase n=6 Tax=Thaumarchaeota RepID=A9A1L0_NITMS Length = 393 Score = 161 bits (407), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 102/351 (29%), Positives = 182/351 (51%), Gaps = 19/351 (5%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ + D+TLR+GEQ S + K+++QIA L+ GVD +E+ PV S E+ +TI Sbjct: 25 KKIRVLDSTLREGEQHPGVSFTNKQRIQIAWMLDYFGVDQIEIS-PVVSNDHKEATKTII 83 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 +Q + + + R +++DIDV+ + +A ++ S +H+ KLR + ++ +ERA Sbjct: 84 KQGLKADIVSHGRALKEDIDVSLD----CDAKWCAAYLGISDIHLKDKLRISREDAMERA 139 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + V+ A+++ + F+ ED R L +V +A AG I++PDTVG P Sbjct: 140 VETVEYAKSHGLKIRFTVEDGSRAEPEFLLKVCKAIEEAGVDRISLPDTVGILRPI---- 195 Query: 183 IISGLYERVPNIDKAI---ISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 G+Y V + +I + H H+D+G AV N+ +A AG Q+ ++GIGER G Sbjct: 196 ---GMYNFVKKVRDSIDVPLDAHVHNDIGFAVANAFSACDAGVDQIHTTIDGIGERTGIP 252 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 L EV +A+ + + S+L+ + + +K IVGS A+ H +G Sbjct: 253 PLAEVAVALTY---LYKSPNDFRLDMLLDLSRLIEEYTTIKPYDSKPIVGSSAYKHKAGT 309 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESE 350 H +L+N YE + P ++G N+ ++ +G+ + M +G + + Sbjct: 310 HLAAILRNPAAYEPIPPRAVG-NRRRIVFGELAGKTGAAYLMSLLGLDKDD 359 >UniRef50_C9RN88 2-isopropylmalate synthase/homocitrate synthase family protein n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RN88_FIBSS Length = 535 Score = 160 bits (406), Expect = 8e-38, Method: Compositional matrix adjust. Identities = 130/454 (28%), Positives = 227/454 (50%), Gaps = 28/454 (6%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFP-VSSPGDFESVQTIA 62 +V+++DTTLRDG Q + SLS+ +K+QIA L+ G D +E G+P S+P D E + I Sbjct: 2 KVLLYDTTLRDGNQDRKISLSLADKVQIARILDHFGFDYIEGGWPNPSNPTDEEFFKLIK 61 Query: 63 R-QVKNSRVCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 ++K++++ A I D ++L +EA F + +H+ +R+TL+E Sbjct: 62 DVKLKHAKIAAFGSTRRPGILPENDPLLQALIKSEAPVKTIFGKSWDLHVTDVIRTTLEE 121 Query: 118 VIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGY 174 ++ V + ++++V + E D + ++AA A I + DT G Sbjct: 122 NLDMIESSVAYLKEHSEEVIYDAEHFFDGYKANPEYALETLKAAELGHADCIVLCDTNGG 181 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 TMP+E I+ + R+ + +H H+D GLAV NS+ AV AG V+G +NG GE Sbjct: 182 TMPWEIEEIVKKVQTRI----STPLGIHVHNDSGLAVANSIYAVKAGCVMVQGVVNGYGE 237 Query: 235 RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFA 294 R GN +L + +K + D + A + + S + QI N+P + VG AFA Sbjct: 238 RCGNANLTTIAADLKFKMD-RDFAAAKKLSHLRQLSGNIDQIVNLPSDVHAPYVGDAAFA 296 Query: 295 HSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAV-KHRMDEMGYKESEYNL 353 H G H DGV+K ++E + P S+G +++ + G V K + + G + + + Sbjct: 297 HKGGAHIDGVMKVSRSFEHIDPHSVGNDRVFVTSDQAGGSLVVEKLKAIKPGIDKKDPVV 356 Query: 354 DNLYDAFLKLADKKGQVFD-----YDLEALAFIGKQQEEPEHFR-LDYFSVQSGSN---D 404 +L +K + G FD + L +G +E F+ L+Y ++ + Sbjct: 357 ASLLKE-IKERENAGWHFDSAEASFKLLVYRHLGMVKEP---FKVLNYRVIEDKTPQGVS 412 Query: 405 IATAAVKLACGEEVKAEAANGNGPVDAVYQAINR 438 ++ A VKL G+++ + + G+GPV+A+ A+ + Sbjct: 413 VSQATVKLQVGDKISHQVSEGDGPVNALDAALRK 446 >UniRef50_B5JMT2 HMGL-like domain protein n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JMT2_9BACT Length = 372 Score = 160 bits (405), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 113/368 (30%), Positives = 185/368 (50%), Gaps = 22/368 (5%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 + DTTLRDGEQA + S+ EK IA L + G+ +EVG P + + ++ I++ Sbjct: 8 LIDTTLRDGEQAAGVAFSLSEKKAIATLLSQTGIPEIEVGIPAMGECERQHIRAISQLDL 67 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY-- 124 + R+ R V +D+ A++S A+ F H + SP+H+ ++ ER + Sbjct: 68 DCRILTWGRAVREDLRAASKS--GADGF--HFSLPASPLHLRIWKKN------ERWVLRT 117 Query: 125 MVKRARNYTDDVEF---SCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 M + A+ D E+ +DA R L ++AA GA+ + I DT G P + Sbjct: 118 MSELAKEAADTFEYFSVGAQDASRADRDFLKLFIDAAQVLGASRVRIADTTGRLNPIDTL 177 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 + + + +ID + H H+DLG+AV N+++A GA +NG+GERAGN +L Sbjct: 178 DLFCDITKNA-SID---LEFHAHNDLGMAVANTVSAFIGGATCASVTVNGLGERAGNAAL 233 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EEV MA+K DI ++ ++ S V+ + NK + G GA +H SGIH Sbjct: 234 EEVSMALKHSTDI---DIPMDASHYYKLSDYVANASQRRLAWNKPVTGPGAHSHESGIHC 290 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 G+L + +YE ++PE IG ++ + + SG AAV ++G+ S L Sbjct: 291 KGLLTDSRSYETVSPEEIGQSRPEFAIGRHSGSAAVIAAAQKLGHTLSAKKATALLPLIR 350 Query: 362 KLADKKGQ 369 A+++G+ Sbjct: 351 TAAEQRGR 358 >UniRef50_B3TC58 Putative HMGL-like protein n=1 Tax=uncultured marine microorganism HF4000_APKG10H11 RepID=B3TC58_9ZZZZ Length = 530 Score = 158 bits (400), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 140/516 (27%), Positives = 258/516 (50%), Gaps = 38/516 (7%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR-QV 65 I DTTLRDG Q + +++EK+ IA L+ +GV+++E G+P S+P D E + I + ++ Sbjct: 13 ILDTTLRDGSQMRGVNFTLQEKIMIATKLDDLGVNIIEGGWPGSNPKDLEFFKLIKKHEL 72 Query: 66 KNSRVCALARCVEKDIDVAAES-LKV---AEAFRIHTFIATSPMHIATKLRSTLDEVIE- 120 +NS++ K+I ++ LKV +EA TS H+ L +L++ +E Sbjct: 73 RNSKIAVFGSTRRKNITAKNDNNLKVMVDSEALVSVIVGKTSSFHVEKILNCSLEDNLEM 132 Query: 121 ---RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMP 177 I++ + D E + P + + V+ A A TI + DT G +P Sbjct: 133 IYDSLIFLRESGLQTYFDAEHFFDGYNINPEYAI-QTVKTAEEAKVNTIVLCDTNGGMLP 191 Query: 178 FEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 + ++ +++ + I H H+D G AV N+++AV AGA ++G +NG+GER G Sbjct: 192 HQIERVV----KKIKKNSEVKIGFHGHNDTGCAVANTVSAVVAGATHIQGTINGLGERTG 247 Query: 238 NCSLEEVI--MAIKVRKDILNVHTA--INHQEIWRTSQLVSQICNMPIPANKAIVGSGAF 293 N L +VI + +K++K N+ IN ++ S ++++ N+ ++ G AF Sbjct: 248 NADLCQVIPNLEMKLKKKTRNIQKKQIINFGKLRDISNYINELVNINSFDHQPYFGKFAF 307 Query: 294 AHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRA---AVKHRMDEMGYKESE 350 +H +G+H DG+LK+ + YE + PE I ++ ++ SG+A A+ + + K+ + Sbjct: 308 SHKAGLHVDGMLKSSKAYEHINPE-IFKSERSFTISELSGKANIIALSKKFNFQIDKDDK 366 Query: 351 YNLDNLYDAFLKLADKKGQVFDYDLEA---LAFIGKQQEEPEHFRLDYFSVQS-GSNDI- 405 +D L + +K + G D + +A L F+ ++F +D + V + N I Sbjct: 367 RIIDILEE--IKKLEFSGFTLD-NADATTYLIFLRHLGLYKQYFHVDSWKVLTEKQNQIN 423 Query: 406 ATAAVKLACGEEVKAEAANGNGPVDAVYQAI-----NRITEYN-VELVKYSLTAKGHGKD 459 + + +K+ GE + A G GPV+++ A+ N+ E N +EL Y ++ G KD Sbjct: 424 SKSEIKILIGENIYTNNAYGVGPVNSLAIALRKSLQNKYPEINKIELTNYKVSIVGASKD 483 Query: 460 ALGQVDIVANYNGRRFHGVGLAT--DIVESSAKAMV 493 V + + AT +I+++S +A++ Sbjct: 484 TASLVRVFIEFKKDEVVWATTATSQNILDASLRALI 519 >UniRef50_Q3M862 2-isopropylmalate synthase n=4 Tax=Bacteria RepID=Q3M862_ANAVT Length = 577 Score = 158 bits (400), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 156/565 (27%), Positives = 266/565 (47%), Gaps = 81/565 (14%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 S + ++DTTLRDG Q S+S ++KL+IA L+++G+ +E G+P ++P D + + Sbjct: 6 SPHIWLYDTTLRDGTQREGLSISTEDKLRIAHRLDQLGIPFIEGGWPGANPKDVQFFWQL 65 Query: 62 ARQ-VKNSRVCALARCVEKDIDVAAESLK----VAEAFRIHTFIATSPMHIATKLRSTLD 116 +K S++ A A E + A + + F + +H+ T L++TL+ Sbjct: 66 QEDPLKLSQIVAFCSTRRPHTHAADEPMLQDILAAGSSWVTIFGKSWDLHVTTGLKTTLE 125 Query: 117 E---VIERAI-YMVKRARNYTDDVEFSCEDAGRTPIADLA-RVVEAAINAGATTINIPDT 171 E +I I + + R D E + G D A + ++AA+ AGA + + DT Sbjct: 126 ENLAMIRDTIEFFRSQGRRVIYDAEHWFD--GYKHNRDYALQTLKAAMAAGAEWLVLCDT 183 Query: 172 VGYTMPFEFAGIISGLYE-----------------------------------RVPNIDK 196 G T+P E + I+ + + +PN+ Sbjct: 184 NGGTLPHEVSQIVQDVVKVTRDWGRINSKLDQSGQVVSEEVEKSTNSLPNTQYPIPNLPF 243 Query: 197 AI--ISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDI 254 I I +HTH+D +AV N+LAAV AGA V+G +NG GER GN +L +I ++++ Sbjct: 244 PIPQIGIHTHNDSDMAVANALAAVMAGATMVQGTINGYGERCGNANLCSLIPNLQLK--- 300 Query: 255 LNVHTAINHQ--EIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYE 312 L HQ ++ S+ VS++ N+ + VG AFAH GIH V +N YE Sbjct: 301 LGYSCITEHQLGQLAEASRFVSEVVNLAPDEHAPFVGRSAFAHKGGIHVSAVERNPLTYE 360 Query: 313 IMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK------ESEYNLDNLYDAFLKLADK 366 + PE +G N+ ++ ++ +SG + V + G + E++ L LK + Sbjct: 361 HIQPEQVG-NRRRIVISEQSGISNVLAKARTFGIELDKQTPEAKQILQR-----LKELES 414 Query: 367 KGQVFDYDLEALAFI------GKQQ-EEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVK 419 +G F+ + A + G+QQ E + F++ V+ A A VK+A + Sbjct: 415 EGYQFEAAEASFALLMYEALGGRQQFFEVKGFQVHCDLVEGKEMTNALATVKVAVNGKNI 474 Query: 420 AEAANGNGPVDAVYQAINR-ITEYNVELVKYSLT------AKGHGKDALGQVDIVANYNG 472 EAA GNGPV A+ A+ + + + +L + LT GH + +V + NG Sbjct: 475 LEAAEGNGPVAALDAALRKALVNFYPQLATFELTDYKVRILDGHTGTSAKTRALVESGNG 534 Query: 473 -RRFHGVGLATDIVESSAKAMVHVL 496 +R+ VG++ +I+ +S +A+V L Sbjct: 535 YQRWTTVGVSPNILAASYQAVVEGL 559 >UniRef50_P74269 Uncharacterized AIPM/Hcit synthase family transferase sll1564 n=103 Tax=cellular organisms RepID=LY41_SYNY3 Length = 547 Score = 158 bits (399), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 145/529 (27%), Positives = 255/529 (48%), Gaps = 51/529 (9%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + ++DTTLRDG Q SLS+ +KL IA L+++G+ +E G+P ++P D + + + Sbjct: 8 LWLYDTTLRDGAQREGISLSLTDKLTIARRLDQLGIPFIEGGWPGANPKDVQFFWQLQEE 67 Query: 65 -VKNSRVCALARCVEKDIDVAAESLKVAEAF------RIHTFIATSPMHIATKLRSTLDE 117 ++ + + A C + A E+ K+ +A + F + +H+ L+++L E Sbjct: 68 PLEQAEIVAF--CSTRRPHKAVETDKMLQAILSAGTRWVTIFGKSWDLHVLEGLQTSLAE 125 Query: 118 ----VIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVG 173 + + Y+ + R D E + P LA + A AGA + + DT G Sbjct: 126 NLAMISDTIAYLRSQGRRVIYDAEHWFDGYRANPDYALATLATAQ-QAGAEWLVMCDTNG 184 Query: 174 YTMPFEFAGI---------ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 T+P + + I + G +R P + +H H+D G AV NSL AV AGA Sbjct: 185 GTLPGQISEITTKVRRSLGLDGQSDRQPQL-----GIHAHNDSGTAVANSLLAVEAGATM 239 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHT-AINHQEIWRTSQLVSQICNMPIPA 283 V+G +NG GER GN +L +I ++++ D + + H + TS+L+S+I N+ Sbjct: 240 VQGTINGYGERCGNANLCTLIPNLQLKLDYDCIEPEKLAH--LTSTSRLISEIVNLAPDD 297 Query: 284 NKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDE 343 + VG AFAH GIH V +N YE + P +G N+ ++ ++ ++G + V + + Sbjct: 298 HAPFVGRSAFAHKGGIHVSAVQRNPFTYEHIAPNLVG-NERRIVVSEQAGLSNVLSKAEL 356 Query: 344 MGYKESEYNLD-NLYDAFLKLADKKGQVFDYDLEALAFIGKQQ--EEPEHFRLDYFSV-- 398 G N A LK +++G F+ + + +Q + F + F V Sbjct: 357 FGIALDRQNPACRTILATLKDLEQQGYQFEAAEASFELLMRQAMGDRQPLFLVQGFQVHC 416 Query: 399 ------QSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINR-ITEYNVELVKYSL 451 ++ + A A VK+ + E A GNGPV A+ QA+ + +T + ++ + L Sbjct: 417 DLLTPAENPAYRNALATVKVTVNGQNILEVAEGNGPVSALDQALRKALTRFYPQIADFHL 476 Query: 452 T-------AKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMV 493 T G G A +V + ++ RR+ VG++ +I+E+S +A+V Sbjct: 477 TDYKVRILDGGAGTSAKTRVLVESSNGDRRWTTVGVSGNILEASYQAVV 525 >UniRef50_D0LNR8 Pyruvate carboxyltransferase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNR8_HALO1 Length = 429 Score = 157 bits (398), Expect = 8e-37, Method: Compositional matrix adjust. Identities = 126/374 (33%), Positives = 193/374 (51%), Gaps = 28/374 (7%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + V I D TLRDGEQA L+V+EKL +A L + GVDV++ GFP SSP D E++Q + Sbjct: 12 KPVEIIDCTLRDGEQAPGVWLTVQEKLALAKLLSQAGVDVLDAGFPASSPADMEAMQEMV 71 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 +R+ A AR + +DI VAAE +A A + F+ TS + + L T D+ I Sbjct: 72 AAGLRARIAATARPLARDI-VAAE---MANAHEVFMFLPTSALRMEQTLGITRDQAISLF 127 Query: 123 IYMVKR--ARNYTDDVEFSCEDAGRT-P--IADLARVVEAAINAGATTINIPDTVGYTMP 177 + +R T ++ F EDA R+ P + ++ R V A A + + DTVG +P Sbjct: 128 CSGAEEVCSRGMTLNLVF--EDATRSRPEMLTEIVRQVHA--QADVRRVILADTVGCAIP 183 Query: 178 FEFAGIISGLYERVPNIDKAI-ISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERA 236 + + ID I ++ H H+D GLAV N+LAAV GA V +NGIGERA Sbjct: 184 AAMEALTRTVRS---EIDADIVVTPHCHNDFGLAVANTLAAVSGGAGAVTCTVNGIGERA 240 Query: 237 GNCSLEEVIMAIKV---RKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAF 293 GN L E + + + R+ ++ H + QE ++ + I P K + G F Sbjct: 241 GNADLAETVAGLSLLLQREHGVDPHQLVALQE---AVEIATGIHQSP---TKPVTGINVF 294 Query: 294 AHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNL 353 H SGIH DG+LK+ +YE + +G + + L SG + ++ R+ M + + + Sbjct: 295 RHESGIHVDGMLKDPRSYEFLPASWVG-RRSEYILGKHSGTSLIR-RLAHMAGLDCDEHT 352 Query: 354 DNLYDAFLKLADKK 367 +L A +K A ++ Sbjct: 353 ASLLLAEVKAATQQ 366 >UniRef50_D2QST1 Pyruvate carboxyltransferase n=1 Tax=Spirosoma linguale DSM 74 RepID=D2QST1_9SPHI Length = 506 Score = 154 bits (390), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 145/521 (27%), Positives = 236/521 (45%), Gaps = 51/521 (9%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 I DTTLRDGEQ S S EKL +A L L + VD +E+ S G+ E+VQ I R Sbjct: 8 IMDTTLRDGEQTSGVSFSASEKLALAQLLLTEVKVDRVEIASARVSAGELEAVQQITRWA 67 Query: 66 KNSRVCALARCVEK----DIDVAAESLKVAEAFRIHTFIATSPMHIATKLRST------- 114 + L VE D + + L+ + A ++ S H+ +L+ T Sbjct: 68 DS---IGLIDKVEVLTFVDGQASLDWLQASGAKVMNLLTKGSLNHLTHQLKKTPGEHFTD 124 Query: 115 LDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGY 174 + +V+ A + +A Y +D + R + + ++ + +PDT+G Sbjct: 125 IGQVVCAAGKLGVKANVYLED----WSNGMRNSPDYVFQYLDFLNTQPILRVLLPDTLGV 180 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 P E + L R PN+ H H+D L++ N + A+ AGA + +NG+GE Sbjct: 181 LTPAESYSFVHQLVTRYPNLH---FDFHAHNDYDLSIANVMEAIRAGAHGIHLTVNGLGE 237 Query: 235 RAGNCSLEEVIMAIKVRKDIL-NVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAF 293 RAGN L AI V +D + V T + + +++ S++V + IP NK +VG F Sbjct: 238 RAGNAPLAS---AIAVLRDFMPEVRTGVVEKSLYQVSKIVETFSGLRIPDNKPVVGDNVF 294 Query: 294 AHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNL 353 ++GIH DG KN + + PE G + L SG+A +++ + E+G + SE +L Sbjct: 295 TQTAGIHADGDKKNNLYFNALLPERFGRKR-SYALGKMSGKANIENNLRELGIQLSEDDL 353 Query: 354 DNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHF--RLDYFS-VQSGSNDI-ATAA 409 + ++L D+K V D L ++ F R++ + V + S D+ +A Sbjct: 354 KKVTQRVIELGDQKEVVTRED---LPYVISDVLNTNSFASRVEVLNYVLTHSKDLKPSAT 410 Query: 410 VKLACGEEVKAEAANGNGPVDAVYQAINRI-----------TEYNVELVKYSLTAKGHGK 458 +++ EE E+A G+G DA A+ +I T+Y V + G Sbjct: 411 LRVRIDEEHFEESAQGDGQYDAFMNALKKIYVKKKLTLPLLTDYAVRI------PTGGRT 464 Query: 459 DALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNI 499 DAL + I + F GL +D S+ KA +LN + Sbjct: 465 DALCETIITWKHKNGEFKTRGLDSDQTVSAIKATQKMLNTL 505 >UniRef50_P54610 Homocitrate synthase n=6 Tax=Frankia RepID=NIFV_FRASP Length = 401 Score = 153 bits (387), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 122/391 (31%), Positives = 185/391 (47%), Gaps = 38/391 (9%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V DTTLRDGEQA + + EKL IA AL+ +GV +E G P + + ++ I Sbjct: 22 VRFCDTTLRDGEQAPGVAFTAAEKLAIAGALDAIGVHQIEAGIPGMGVTERDVLREILAT 81 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 + + R +D++ AA V H I S +H+ +KL +RA + Sbjct: 82 DPKAEIVGWCRADHRDVEAAASCGLVTA----HLTIPVSDLHLKSKLER------DRA-W 130 Query: 125 MVKRARNYTDD-------VEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMP 177 +R R+ D V EDA R A + + + G T + DTVG P Sbjct: 131 ARRRVRDCVVDGTDRGMRVSVGFEDASRADDAFVTDLAGELRDVGVTRLRWADTVGLLDP 190 Query: 178 FEFAGIISGLYERVPNIDKAI---ISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 Y+R+ + +A+ +H HDD GLA N++AAV AG V + G+GE Sbjct: 191 VS-------AYDRLGRLVRAVPGPWEIHAHDDFGLATANTIAAVQAGFTWVSTTVLGLGE 243 Query: 235 RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN-KAIVGSGAF 293 RAGN +EEV MA+ + +L + ++ +QLV P+PA KA+VG F Sbjct: 244 RAGNAPIEEVAMAL---RHLLKLPIDLDTTSFRTLAQLV---VGWPLPAGKKAVVGESVF 297 Query: 294 AHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNL 353 AH SGIH G+L++ YE PE G + +L + SGRA+++H +++ G E L Sbjct: 298 AHESGIHVHGILRHPATYEPFDPEVGG--RRRLTVGKHSGRASLRHALEQCGITAEESEL 355 Query: 354 DNLYDAFLKLADKKGQVFD-YDLEALAFIGK 383 + L + A + + D DL + G+ Sbjct: 356 EPLVEQVRLAATRHKRGLDSRDLPGTSRAGR 386 >UniRef50_B6YRB4 Homocitrate synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YRB4_AZOPC Length = 374 Score = 152 bits (385), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 97/331 (29%), Positives = 162/331 (48%), Gaps = 12/331 (3%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 + D+TLRDGEQA KEK+++A L +G+D +EVG P + ++Q I R Sbjct: 7 LIDSTLRDGEQAPNVVFLRKEKIRLAQMLSEIGIDEIEVGIPAMGEDECNTIQNIVRLKL 66 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 + +R ++KDI+ A+ A IH S + + + T V + + Sbjct: 67 RPIISVWSRAIKKDIEQAS----TLGATCIHIAFPLSDIQLQA-INKTYGWVEDTFSKTI 121 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 + A+N + V +DA R PI + + ++ A G + DTVG P + II Sbjct: 122 QCAKNLFERVSVGAQDASRCPIDRVIQFIDMAEKYGVFRVRFADTVGILTPIQTIEIIRT 181 Query: 187 LYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIM 246 + ++ N++ I H H+D G+A N+L A GA + +NG+GERAGN +LEE++M Sbjct: 182 IKKKKTNMN---IDFHAHNDFGMATANALTAYQVGANSLSVTINGLGERAGNAALEEILM 238 Query: 247 AIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLK 306 ++ +N T + ++ + VS I P+P KAI G A +H SGIH +L Sbjct: 239 GLRQ----INGKTKYDLSTLFDLCRYVSVISGRPLPDGKAICGKFAVSHESGIHTQAILS 294 Query: 307 NRENYEIMTPESIGLNQIQLNLTSRSGRAAV 337 + ++ + +G + + SG+ A+ Sbjct: 295 DILAFQPFNGDILGREKCSILFGKHSGKRAI 325 >UniRef50_Q0ZQ46 FrbC n=3 Tax=Bacteria RepID=Q0ZQ46_9ACTO Length = 373 Score = 152 bits (383), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 107/374 (28%), Positives = 181/374 (48%), Gaps = 12/374 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M +++ DTTLRDGEQ + S + K I AL GV +E+G P + + +++ Sbjct: 1 MRNDLVLEDTTLRDGEQTPGVAFSKETKTAILNALIEAGVTSIEIGIPAMGGEELDFIKS 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 + + +R+ R V +D++ SL + +H + TS H+ +R ++ Sbjct: 61 VVDRQDEARLVVWHRGVREDVE---RSLDLGFT-SVHVGLPTSAGHLKASVRKDRTWLLA 116 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 A MVK A++ V S ED RT I+ L AGA + + DTVG P + Sbjct: 117 TARDMVKMAKDRGAFVSISAEDIARTEISFLQEYAGVVAEAGADRLRLSDTVGLLGPEAY 176 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 ++ + +ID + H H+D GLA N+LA + AGAR +N IGERAG Sbjct: 177 GERVAAVLS-AADID---VQCHAHNDFGLATANTLAGLKAGARYFHVTVNAIGERAGMAD 232 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 L +V++A+ K + + I+ ++ + S+LV++ + + I G FAH SGIH Sbjct: 233 LAQVVVAL---KKLYDRDLGIDLTKLKKVSRLVAEAAGHQVLPWQPITGDNVFAHESGIH 289 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 +G+ ++ ++E PE +G + + L SGRA V +++ G E L + + Sbjct: 290 ANGMFRDTSSFEPFPPEHVG-GERRYVLGKHSGRALVAWALEQEGITPREELLPHCLEEV 348 Query: 361 LKLADKKGQVFDYD 374 L+ + G ++ Sbjct: 349 RALSIRIGGAVSHE 362 >UniRef50_B0TAQ1 Homocitrate synthase, nifv n=4 Tax=Clostridiales RepID=B0TAQ1_HELMI Length = 380 Score = 152 bits (383), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 111/359 (30%), Positives = 172/359 (47%), Gaps = 18/359 (5%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M Q+V + DTTLRDGEQ + +EK +A L GV +E G P + E++ Sbjct: 1 MRQRVWLMDTTLRDGEQTPGVAFCPQEKALLARRLAEAGVHEIETGVPAMGEDEQETIAR 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I + +RV R V D++ SL + + +S I KLR + V++ Sbjct: 61 IVKLNLPTRVTTWNRAVISDLEA---SLNCG-VRSVAICLPSSDQQITQKLRQSRQWVLD 116 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTIN---IPDTVGYTMP 177 + V+RA+ V EDA R AD +++ + A +N I DT+G P Sbjct: 117 QMGACVRRAKAEGLYVVIGLEDASR---ADPQFLIQLGLEAERLKVNRLRISDTLGILDP 173 Query: 178 FEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 L++R+ + + +H H+DLG+A N+++A+ AGA+ + G+GERAG Sbjct: 174 IR----TFNLFDRLTSSLSIPLEIHAHNDLGMATANTVSAIQAGAKAASVTVCGLGERAG 229 Query: 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 N LEEV +A+ + T IN + +LVS PIP +K +VG AF H+S Sbjct: 230 NAPLEEVALAL---RQCCAADTRINLALLPALCRLVSWSTRRPIPFSKPVVGRDAFTHAS 286 Query: 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNL 356 IH DG+ K+R NYE PE +G ++ SGR + + G+ + + L Sbjct: 287 SIHVDGLNKDRSNYEAYPPEYVGRRH-RIAFGKYSGRKLLAELLKAQGHDLDQEEMTQL 344 >UniRef50_Q0PQP5 2-isopropylmalate synthase (Fragment) n=2 Tax=Endoriftia persephone 'Hot96_1+Hot96_2' RepID=Q0PQP5_9GAMM Length = 156 Score = 149 bits (377), Expect = 2e-34, Method: Composition-based stats. Identities = 75/123 (60%), Positives = 94/123 (76%), Gaps = 1/123 (0%) Query: 71 CA-LARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRA 129 CA LAR ++KDI+ A E+LK A + RIHTFIATSP+H+ KLR + D+V+E+A+ VKRA Sbjct: 18 CAGLARALDKDIERAGEALKEANSGRIHTFIATSPIHMEQKLRMSPDQVVEQAVAAVKRA 77 Query: 130 RNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYE 189 RNYTDDVEFS EDAGR+ + L R+ EA I+AGATT+N+PDTVGY MP +F I L E Sbjct: 78 RNYTDDVEFSAEDAGRSELDFLCRIFEAVIDAGATTLNVPDTVGYAMPDQFGETIRALRE 137 Query: 190 RVP 192 R P Sbjct: 138 RSP 140 >UniRef50_Q2FZS6 2-isopropylmalate synthase, putative n=51 Tax=Staphylococcus aureus RepID=Q2FZS6_STAA8 Length = 381 Score = 149 bits (377), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 107/362 (29%), Positives = 173/362 (47%), Gaps = 17/362 (4%) Query: 9 DTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNS 68 D T+RDG Q S+ K ++ + ++ ++ +EVG + +F Q Sbjct: 6 DNTIRDGMQQSNVRKSLIIKKEVLKQINKLNINSVEVGMCTTIEDEFNIHQFRDILSPEK 65 Query: 69 RVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKR 128 + L R EK+I + LK+ + + S +HI KL + I++ + Sbjct: 66 ELVVLTRLNEKEIKKIVK-LKI-HNLVVKILLPISDLHIKEKLNFSNKYYIQKIKDCLDI 123 Query: 129 ARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLY 188 + V+ ED RT L +E T+ DTVG + P E+ I + Sbjct: 124 LKKDKKGVDICFEDGTRTSREKLKEYMEIISKYQVRTVTFADTVGCSTPLEYGDIFNYFV 183 Query: 189 ERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAI 248 ++ NI I S H H+DLGLA N+LAA+ GA+Q+E GIGERAGN +EE+I I Sbjct: 184 KKYSNI---IFSAHCHNDLGLATANTLAAILNGAKQIETTFLGIGERAGNAPIEEII-TI 239 Query: 249 KVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNR 308 +K I + T ++++TS +S+I + I NK I+G F H SGIHQDG KN Sbjct: 240 LTKKQIES--TEFTLPDVYKTSINISKILDFQISENKPIIGENIFKHESGIHQDGTKKNI 297 Query: 309 ENYEIMTPESIGLNQ---IQLNLTSRSGRAAVKHRMDEM-GYKESEYNLDNLYDAFLKLA 364 Y+ + P +GL +Q +++ S + + ++ + +E + N+ +F KL Sbjct: 298 NMYQYLVPSDLGLKNSQVVQFPISNISSKKILHNKFKSIVNTEEIDENI-----SFYKLV 352 Query: 365 DK 366 +K Sbjct: 353 NK 354 >UniRef50_O86511 Uncharacterized AIPM/Hcit synthase family transferase SCO5529 n=62 Tax=Bacteria RepID=LY41_STRCO Length = 534 Score = 149 bits (375), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 146/517 (28%), Positives = 253/517 (48%), Gaps = 43/517 (8%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV- 65 +FDTTLRDG Q +L+V +KL IA L+ GV +E G+P ++P D E +++ Sbjct: 13 VFDTTLRDGAQREGINLTVADKLAIARHLDDFGVGFIEGGWPGANPRDTEFFARARQEID 72 Query: 66 -KNSRVCALARCVEKDIDVAAESLKVAEAF----RIHTFIATS-PMHIATKLRSTLDEVI 119 K++++ A + AAE +V ++ T +A S H+ LR+TLDE + Sbjct: 73 FKHAQLVAFGSTRRAGAN-AAEDHQVKALLDSGAQVITLVAKSHDRHVELALRTTLDENL 131 Query: 120 ERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGYTM 176 V + V CE D R VV A AGA + + DT G + Sbjct: 132 AMVADTVSHLKAQGRRVFVDCEHFFDGYRANPEYAKSVVRTASEAGADVVVLCDTNGGML 191 Query: 177 PFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERA 236 P + +++ + A + +H DD G AV N+LAAV AGA V+ NG GER Sbjct: 192 PAQIQAVVATVLADT----GARLGIHAQDDTGCAVANTLAAVDAGATHVQCTANGYGERV 247 Query: 237 GNCSLEEVIMAIKVR--KDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFA 294 GN +L V+ A++++ K +L +E+ R S ++++ N+ ++ VG AFA Sbjct: 248 GNANLFPVVAALELKYGKQVL---PEGRLREMTRISHAIAEVVNLTPSTHQPYVGVSAFA 304 Query: 295 HSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLD 354 H +G+H + + + Y+ + PE +G N +++ ++ +GRA+++ + E+G + + Sbjct: 305 HKAGLHASAIKVDPDLYQHIDPELVG-NTMRMLVSDMAGRASIELKGKELGIDLGG-DRE 362 Query: 355 NLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQS----------GSND 404 + ++ +++ + Y+ +F + E E L YF V+S GS+ Sbjct: 363 LVGRVVERVKERELAGYTYEAADASFELLLRAEAEGRPLKYFEVESWRAITEDRPDGSH- 421 Query: 405 IATAAVKL-ACGEEVKAEAANGNGPVDAVYQAINRITEY------NVELVKYSL-TAKG- 455 A VKL A GE + A A GNGPV+A+ +++ E ++LV Y + +G Sbjct: 422 ANEATVKLWAKGERIVA-TAEGNGPVNALDRSLRVALEKIYPELAKLDLVDYKVRILEGV 480 Query: 456 HGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAM 492 HG + +V I + + VG+A +++ +S +A+ Sbjct: 481 HGTQSTTRVLISTSDGTGEWATVGVAENVIAASWQAL 517 >UniRef50_A0LSS5 2-isopropylmalate synthase n=12 Tax=Bacteria RepID=A0LSS5_ACIC1 Length = 554 Score = 147 bits (372), Expect = 8e-34, Method: Compositional matrix adjust. Identities = 139/521 (26%), Positives = 253/521 (48%), Gaps = 51/521 (9%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV- 65 ++DTTLRDG Q +L+V +KL IA L+ +GV +E G+P + P D E + ++ Sbjct: 19 VYDTTLRDGAQGEGMALTVADKLAIARHLDDLGVGFIEGGWPGALPKDTEFFRRARTELT 78 Query: 66 -KNSRVCALARCVEKDIDVAAE----SLKVAEAFRIHTFIATSPMHIATKLRSTLDE--- 117 +N+ + A + + V A+ +L AE + + H++ LR++LDE Sbjct: 79 LRNAVLVAFGATRKPESRVEADPQVLALLEAETPAVCLVAKSHVRHVSEALRTSLDENLA 138 Query: 118 -VIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTM 176 + + + + R D E + P + V A +GA + + DT G + Sbjct: 139 MIRDTVAFFRREGRRVFLDAEHFFDGYAADPQYAV-ECVRVAAESGAEVVVLCDTNGGML 197 Query: 177 PFEFAGIISGLYER--VPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 P A ++ + ER VP + +H HDD G AV N+LAAV AG QV+G +NG GE Sbjct: 198 PPRIADVVHEVAERTGVP------LGIHCHDDTGCAVANTLAAVDAGVVQVQGVVNGYGE 251 Query: 235 RAGNCSLEEVI--MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 R GN +L V+ + +K+ + +L E+ R S ++++ N P AN+ VG A Sbjct: 252 RCGNANLITVVANLELKMGRRVL---PPGRLAELGRVSHAIAEVANQPPRANQPYVGLSA 308 Query: 293 FAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYN 352 FAH +G+H + + + Y+ + P +G N +++ ++ +GRA+V+ + ++G ++ Sbjct: 309 FAHKAGLHASAIKVSPDLYQHIDPALVG-NDMRMLVSEMAGRASVELKSRQLG-----FD 362 Query: 353 LDNLYDAFLKLADK----KGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSG------- 401 L DA ++ ++ + + F ++ +F +EE + +F ++S Sbjct: 363 LSGQRDAVSRIVERVKNLEARGFMFEAADASFELLLREELDGVPTRFFDLESWRVIVERR 422 Query: 402 --SNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEY------NVELVKYS--L 451 ++ A VK+ E A GNGPV+A+ +A+ + E +ELV Y + Sbjct: 423 ADGEVVSEATVKVVVKGERIVATAEGNGPVNALDRALRQALERLYPQLAELELVDYKVRI 482 Query: 452 TAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAM 492 HG A+ +V I + + +G+ +++ +S +A+ Sbjct: 483 LDGSHGTGAVTRVLIETSDGETEWTTIGVDGNVISASWQAL 523 >UniRef50_Q3IV11 Isopropylmalate/homocitrate synthase n=1 Tax=Rhodobacter sphaeroides 2.4.1 RepID=Q3IV11_RHOS4 Length = 336 Score = 146 bits (368), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 101/302 (33%), Positives = 158/302 (52%), Gaps = 16/302 (5%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 ++ +I D TLR+G QA SV + + IA AL+ +GVD++E+G P++ P + + + +A Sbjct: 4 KRTLINDATLREGNQASGVRFSVHDSVAIATALDGIGVDMIEIGHPLAGPYEHQRTEAVA 63 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLR---STLDEVI 119 + +++ A AR DI E++ A + F+ + I TK R + E+I Sbjct: 64 KLGLGAKIIAHARAHRTDI----EAVSRTGATWVGIFLGVN--DITTKARVIGRSTTELI 117 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE 179 VK A++ ++ +SCEDA RT L V AAI+AGA I DT+G P E Sbjct: 118 RMVADAVKVAKDCGLNIRYSCEDASRTNTLFLVDVFGAAIDAGADRICYADTLGIAEPAE 177 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 A ++ + P+ A + VH HDD GLA+ NSLAA+ AG + ++N +GER G Sbjct: 178 VARKVTLMKSEFPD---AEVEVHLHDDRGLAMANSLAAIDAGVDSISVSVNALGERCGIT 234 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 L +++ + R + + E+ S+LV+ N P A + IVG AF H S + Sbjct: 235 DLATLLVNLGFRGE----RALPDISELRALSRLVAMSSNTPFDALRPIVGDNAFKHGSKL 290 Query: 300 HQ 301 HQ Sbjct: 291 HQ 292 >UniRef50_A4MW39 2-isopropylmalate synthase n=3 Tax=Haemophilus influenzae RepID=A4MW39_HAEIN Length = 146 Score = 144 bits (364), Expect = 6e-33, Method: Compositional matrix adjust. Identities = 76/137 (55%), Positives = 95/137 (69%), Gaps = 1/137 (0%) Query: 370 VFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLAC-GEEVKAEAANGNGP 428 +FDYDLEALAFI QQ + + LD S S ATA V+L GE++ + GNGP Sbjct: 1 MFDYDLEALAFIDMQQGDEDRLVLDKLSAHSTKEYPATAFVQLKLDGEKLSTSSIGGNGP 60 Query: 429 VDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESS 488 VDAVY AI +T +++ Y+LTAKG G +ALGQVDIV + GR+FHGVGLATDIVESS Sbjct: 61 VDAVYNAILNLTGLEIKMSHYNLTAKGEGAEALGQVDIVVEHKGRKFHGVGLATDIVESS 120 Query: 489 AKAMVHVLNNIWRAAEV 505 A A+VH +N I+RA +V Sbjct: 121 ALALVHAINAIYRAHKV 137 >UniRef50_Q01181 Homocitrate synthase n=27 Tax=Proteobacteria RepID=NIFV_RHOSH Length = 391 Score = 144 bits (364), Expect = 7e-33, Method: Compositional matrix adjust. Identities = 120/377 (31%), Positives = 172/377 (45%), Gaps = 16/377 (4%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V + DTTLRDGEQ + + EK IA AL+ GV +EVG P + ++ +A Sbjct: 19 VALCDTTLRDGEQTAGVAFTRAEKRAIAEALQAAGVAEVEVGVPAMGEEERADIRAVAAV 78 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 +K + R +D+ A + V R+H + S I+ KL V ++ Sbjct: 79 LKTAAPVVWCRLRAEDLAAAQRTGVV----RLHIGVPVSERQISAKLGKDAAWVRDKVEK 134 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 +V+ A V EDA R LA + A AGA I DT+G PF ++ Sbjct: 135 LVRAASWAGHKVSVGAEDASRADPFFLAEIAHVAAEAGAIRFRISDTLGVLDPFAAHELV 194 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + R P + H H+DLG+A NSLAA AGA + +NG+GERAGN +LEEV Sbjct: 195 GRVVTRCP----LPVEFHGHNDLGMATANSLAAARAGASHLSVTVNGLGERAGNAALEEV 250 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 A++ T + ++ S+LV++ P+ K IVG G F H GIH DG+ Sbjct: 251 AAALEA----AGRATGVALGQLCALSELVARASGRPLSPQKPIVGEGVFTHECGIHVDGL 306 Query: 305 LKNRENYEI--MTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 +K+R YE + PE G + ++ + S A + + E G L L A Sbjct: 307 MKDRATYESADLRPERFGRSH-RIAIGKHSSAAGLARALAEAGLPADAATLAALMPALRD 365 Query: 363 LAD-KKGQVFDYDLEAL 378 A K DL AL Sbjct: 366 WAAITKRAAAPEDLAAL 382 >UniRef50_Q04TA5 2-isopropylmalate/homocitrate synthase n=14 Tax=Bacteria RepID=Q04TA5_LEPBJ Length = 516 Score = 144 bits (362), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 143/513 (27%), Positives = 226/513 (44%), Gaps = 32/513 (6%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct: 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIIEWA 69 Query: 66 KNSRVCALARCVE-KDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE------- 117 + ++ + D + + +K + A ++ S H+ +L T E Sbjct: 70 ETEQLTERIEILGFVDGNKTVDWIKDSGARVLNLLTKGSLHHLEKQLNKTPKEFFADVSI 129 Query: 118 VIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMP 177 VIE AI + Y +D + R + +V+ I +PDT+G P Sbjct: 130 VIEYAIKNGLKINVYLED----WSNGFRNSPDYVEALVKHLSKERIERIFLPDTLGVLSP 185 Query: 178 FE-FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERA 236 E F G+ S L ++ PN+ H H+D L+V NSL A+ AG + + +MNG+GERA Sbjct: 186 EETFQGVDS-LVQKYPNLH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASMNGLGERA 241 Query: 237 GNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHS 296 GN LE ++ I D T IN I S+LV I AN+ IVG F + Sbjct: 242 GNTPLEALVTTI---HDKSQAKTNINELAITEASRLVEVFSGKRISANRPIVGEDVFTQT 298 Query: 297 SGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNL 356 +G+H DG K + PE G + L SG+A++ + ++G S+ L + Sbjct: 299 AGVHADGDKKGNLYANPILPERFGRKR-SYALGKLSGKASISENVKQLGMVLSDIVLQKV 357 Query: 357 YDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGE 416 + ++L D+ V DL + + + + ++ SG A ++L Sbjct: 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGVRPHAQIELEYQG 417 Query: 417 EVKAEAANGNGPVDAVYQAINRITEYN----VELVKYSLTAKGHGK-DALGQVDIVANYN 471 +V E + G+G DA A+ +IT +L+ Y + GK DAL + I N + Sbjct: 418 KVHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETMITWNKS 477 Query: 472 -----GRRFHGVGLATDIVESSAKAMVHVLNNI 499 + F +G+ D ++ A +LN I Sbjct: 478 LDLEEDQTFKTMGVHPDQTIAAVHATEKMLNQI 510 >UniRef50_C6BX35 Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio salexigens DSM 2638 RepID=C6BX35_DESAD Length = 368 Score = 144 bits (362), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 112/365 (30%), Positives = 190/365 (52%), Gaps = 25/365 (6%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 ++ DTTLR+G Q A +++ + +IA +L MGVD +E+G+ D AR + Sbjct: 1 MLIDTTLREGAQLFGAYFNLETRKRIASSLISMGVDEIEMGW--VGQDDLALFAGYARTL 58 Query: 66 K-NSRVCALARCVEKDIDVAAE-SLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 ++ + + C EKDI+VAAE LK RI+ + S +HI +L S ++ + Sbjct: 59 GGDTALSVWSPCREKDIEVAAELGLK-----RINIGVPVSDLHIEKRLDSDRQAILRKLA 113 Query: 124 YMVKRARNYT-DDVEFSCEDAGRTPIADLARVVEAAINA---GATTINIPDTVGYTMPFE 179 V+ A++ + V ED R AD + A++A GA+ + + D++G P Sbjct: 114 AAVRTAKDCGFEYVSVGLEDISR---ADGDFALSMALHAEICGASRVRLADSLGQLTPLA 170 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 ++ E++ +ID I+VH HDD G+A NS A+ AGA + ++ GIGER+G Sbjct: 171 MEKLVRKFREKL-HID---IAVHCHDDFGMATANSFTALEAGADYADCSVIGIGERSGIA 226 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 + EE++ + +R+ T + + +V + IP KA+VG+ FA SG+ Sbjct: 227 ATEELVARLALREGNTRYSTTV----LKDACMVVGAAAKVAIPRTKAVVGTDIFACESGL 282 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 H + K+ E +E P+S+G + +L + +SGRAAV++ +DE G +L L +A Sbjct: 283 HTHALSKSPELFEPYDPDSVGTVR-KLAVGGKSGRAAVRNALDEYGIDCGTDSLSTLTEA 341 Query: 360 FLKLA 364 +L+ Sbjct: 342 VRQLS 346 >UniRef50_Q52070 Homocitrate synthase n=9 Tax=Gammaproteobacteria RepID=NIFV_ENTAG Length = 400 Score = 141 bits (356), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 108/346 (31%), Positives = 163/346 (47%), Gaps = 12/346 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 VII DTTLRDGEQ+ + EKL+IA AL GV +E G P + + + RQ Sbjct: 18 VIINDTTLRDGEQSPGVAFRASEKLEIAQALVNAGVRELEAGTPALGEEECVRLAILRRQ 77 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 + ++ + + R +I +S +V + + + S + KL VI Sbjct: 78 LPDTVMMSWCRMNSAEIH---DSARVGMDW-VDISVPASDLLREQKLHRPWPAVIASLKP 133 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 +V+ A V CEDA R+ L + E A + G + DT+G PF I Sbjct: 134 LVQLAHRLGMRVCMGCEDASRSADETLHMLAEVAADLGIERMRFADTLGILDPFSTFTRI 193 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 S L + + +H H+DLG+A N+LAAV AGA V + G+GERAGN +LE V Sbjct: 194 SALRQHW----HGGLEIHAHNDLGMATANTLAAVRAGATHVNTTVLGLGERAGNAALESV 249 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 +++ L++ I+ E+ +LV+ I +VG F H SG+H + Sbjct: 250 TLSL---DRCLHLDCGIDFTELPALCRLVAAAAGRTIDVQHPLVGGQVFTHESGLHVAAL 306 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESE 350 L++ +Y+ + P +G + L L SGR AV +GY SE Sbjct: 307 LRDPRSYQGIDPSLVG-REFNLVLGKHSGRQAVSGICARLGYILSE 351 >UniRef50_A3JSY7 Putative uncharacterized protein n=2 Tax=Bacteria RepID=A3JSY7_9RHOB Length = 403 Score = 141 bits (355), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 101/346 (29%), Positives = 174/346 (50%), Gaps = 13/346 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + +V I D TLRDGEQ S+ +K+ IA L+ +GVD +E G P SP D ++ Sbjct: 28 LPAKVEIHDATLRDGEQTPGVVFSIDDKIAIASKLDELGVDRIEAGMPAVSPQDATAITE 87 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I++ S++ AR ++ DID+A + A+ I I + T+ T ++V++ Sbjct: 88 ISKLGLKSKIYTFARAMKADIDMALQC--GADGVIIEVPIGYP--KLKTQFGWTWEDVVK 143 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAIN-AGATTINIPDTVGYTMPFE 179 ++ ++ A+ F D R +DL + +A ++ + I + DT+G P Sbjct: 144 KSAPVINYAKENGLHAVFFPYDTTRARRSDLENMCKAIMDQSPPDAIGLVDTMGCATPEA 203 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 ++ L + + + + +HTH+D G+ V LAAV AGA+ V NG+GER GN Sbjct: 204 IKYMVRWLTK----MTELPVEIHTHNDFGMGVATELAAVTAGAQCVHSCANGLGERTGNA 259 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 +LEE++M + + + T +I L+++ N+ I NK ++G G F SGI Sbjct: 260 ALEELMMGLHL---LYGYDTQYKLGKIPELGALIAERSNISIARNKPVLGHGNFIRESGI 316 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMG 345 D V+ N T S+ ++ L +SG+A++ ++M E+G Sbjct: 317 GIDYVM-NDPLVMFGTHPSLTGKVGEVVLGKKSGKASIIYKMGELG 361 >UniRef50_A5KHS6 3-isopropylmalate dehydrogenase n=1 Tax=Campylobacter jejuni subsp. jejuni CG8486 RepID=A5KHS6_CAMJE Length = 156 Score = 140 bits (354), Expect = 9e-32, Method: Compositional matrix adjust. Identities = 73/148 (49%), Positives = 96/148 (64%), Gaps = 2/148 (1%) Query: 360 FLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVK 419 F L KKGQV+DYDLEAL F+ + EE F L+ SV SG +I TA V + EE+K Sbjct: 7 FYALRIKKGQVYDYDLEALMFLSYENEEENEFILEKLSVISG--NIPTACVCMRIKEELK 64 Query: 420 AEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVG 479 EA GNGPV+AV+ I RIT L YS+ AK G DA GQVD+ + GR+FHG G Sbjct: 65 TEACTGNGPVEAVFNCIARITNLKPALKAYSINAKSSGVDAQGQVDVDLEFKGRKFHGKG 124 Query: 480 LATDIVESSAKAMVHVLNNIWRAAEVEK 507 ++TD++E+SA+A V N I+R+ +VE+ Sbjct: 125 ISTDVIEASAQAFVSAYNAIYRSLKVEE 152 >UniRef50_B9YLN5 2-isopropylmalate synthase n=2 Tax=Nostocaceae RepID=B9YLN5_ANAAZ Length = 394 Score = 140 bits (354), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 115/388 (29%), Positives = 190/388 (48%), Gaps = 35/388 (9%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I D+TLR+GEQ S K KL IA L+R+G+D++EVG P ++ IA Sbjct: 4 ILDSTLREGEQTPGVYFSPKTKLVIAQFLDRIGIDIIEVGNPAVDTEIALAINQIANAGL 63 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 +++ A + C ID ++L F + F + SP + L+ I++ + ++ Sbjct: 64 KAKIGAHSLC---KIDSVQKALDCDVDF-LGIFFSVSPQRLYRDYNICLERAIDKIVEVI 119 Query: 127 KRARNYTDD--VEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 AR D + ++ ED R+PI ++ +AA+ AGA I+I DT GYT PF Sbjct: 120 SYARTQKSDLLIRYTPEDTVRSPIENVIAAAKAAVQAGANIISIADTTGYTNPFHPQ--- 176 Query: 185 SGLYERVPNIDKAI--------ISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERA 236 +Y V + + + I VH H+D GLA+ N L A AGA ++ A+ G+GERA Sbjct: 177 RSIYFYVKTVKEELGKEGLYPQIEVHCHNDKGLALANVLDAYRAGADIIDVAVMGLGERA 236 Query: 237 GNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQL------VSQICNMPIPANKAIVGS 290 G L E+ ++N+ W+ + L VS+ ++ IP ++A+ G Sbjct: 237 GIVDLAEL---------LINLIDMDEEGNFWQLNYLKDLYDFVSEQSHISIPPHQAVTGK 287 Query: 291 GAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESE 350 AF H +G+H V K+ Y+ + P+ +G+ + L +SG AAV+ + ++G ++ Sbjct: 288 YAFTHYAGVHVKAVAKDERLYQSLNPQILGIKS-SVALGMQSGCAAVELAIKQIGREDLA 346 Query: 351 YNLDNLYDAF--LKLADKKGQVFDYDLE 376 N D + +K K+G D + E Sbjct: 347 RNKDLITKILKEIKEISKRGTPIDIEKE 374 >UniRef50_C0W2B6 Alpha-isopropylmalate/homocitrate synthase family transferase n=1 Tax=Actinomyces urogenitalis DSM 15434 RepID=C0W2B6_9ACTO Length = 551 Score = 139 bits (351), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 152/545 (27%), Positives = 249/545 (45%), Gaps = 53/545 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFE---- 56 ++ +V +DTTLRDG Q S +V++KL +A L+ +GV +E G+P + P D E Sbjct: 3 LTPRVATYDTTLRDGAQQQSVSFTVEDKLAVARILDHLGVTYIEAGWPGAIPKDTEFFAR 62 Query: 57 -----SVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKL 111 S+ T AR V C EKD + L + A I + P H+ L Sbjct: 63 AASELSLAT-ARLVAFGSTCHPGTAAEKDPQL--RGLLDSGAPVITIVAKSDPAHVERAL 119 Query: 112 RSTLDE----VIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTIN 167 R++ +E V + +V R D+E + R P + + AA AGA+ + Sbjct: 120 RTSGEENLRMVADSVGLLVAAGREVMVDLEHYVDGVARDPRYGIELALTAA-RAGASAVI 178 Query: 168 IPDTVGYTMPFEFAGIISGLYERV--PNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQV 225 DT G ++P A IS L + + ++ +HTHDD GLAV ++AAV AGARQV Sbjct: 179 PCDTNGGSLPGTVAAEISRLRAALDAAGHEDCVVGIHTHDDSGLAVAAAMAAVEAGARQV 238 Query: 226 EGAMNGIGERAGNCSLEEVIMAIKVRKDILNV-----HTAINHQEIWRTSQLVSQICNMP 280 +G +NG GER GN +L +I ++++ + A E+ S+ V +I N Sbjct: 239 QGCVNGFGERTGNANLLTLIANLELKTGYQALAGDSQERARRLAELSAVSRTVGEIANRA 298 Query: 281 IPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHR 340 VGS AFAH +G+H + + Y+ + P +G N + + ++ +GRA+++ + Sbjct: 299 PSGRLPYVGSKAFAHKAGLHASAIKVDPNLYQHVDPARVG-NTMTMLVSEMAGRASIELK 357 Query: 341 MDEMGYKE-SEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQ--EEPEHFRLDYFS 397 E+G + + L +K + G +D + + +Q + P++FR++ + Sbjct: 358 ARELGIETGGDKELLARVTEVVKGREAAGYAYDAADGSFELLLRQALGQLPQYFRVESWR 417 Query: 398 VQSGSN----------DIAT-----AAVKLACGEEVKAEAANGNGPV--------DAVYQ 434 + D AT A V++ G A GNGPV DA+ Sbjct: 418 ASVTARPAAGQEILPEDGATVTDSEATVRMWVGGRRLAVLGEGNGPVNALDHALCDALAT 477 Query: 435 AINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMV- 493 A I + + K + G A+ +V I R + VG+ TDI+E+S +A+ Sbjct: 478 AYPEIRAFELTDFKVRILDSERGTHAIVRVLIDITDGERSWSTVGVGTDIIEASWEALTD 537 Query: 494 -HVLN 497 HV+ Sbjct: 538 GHVVG 542 >UniRef50_Q0EZI5 2-isopropylmalate synthase n=1 Tax=Mariprofundus ferrooxydans PV-1 RepID=Q0EZI5_9PROT Length = 543 Score = 139 bits (350), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 142/528 (26%), Positives = 266/528 (50%), Gaps = 56/528 (10%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGD---FESVQ 59 +++ ++DTTLRDG Q+ S ++K +IA L G+D +E G+P +SP D FE ++ Sbjct: 8 RRIQLYDTTLRDGAQSAGIHFSAEDKKRIARRLASFGMDWIEGGWPGASPTDDCFFELMR 67 Query: 60 TIARQVKNSRVCALARCVEK----DIDVAAESLKVAEAFRIHTFIATSPMHIAT----KL 111 R +SR+ A D L A + F + +H+ T L Sbjct: 68 D--RAWSHSRLVAFGSTARPGHPASEDPGLARLVACGADAVCIFGKSWDLHVTTGLGIDL 125 Query: 112 RSTLDEVIERAIYMVKRARNYTDDVEFSCEDA--GRTPIADLA-RVVEAAINAGATTINI 168 ++ LD V E ++ + + D V F E G D A +V+ AA +AGA ++ + Sbjct: 126 QTNLDLVRESVAWL----KLHVDTVLFDAEHFFDGYAANRDYAMQVLAAAADAGADSLVL 181 Query: 169 PDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGA 228 DT G ++P + + + R P++ I +H H+D +AV N+++AV AGA V+G Sbjct: 182 CDTNGGSLPEQIGACVRQVVARYPDL---TIGIHAHNDSEMAVANAVSAVSAGASHVQGT 238 Query: 229 MNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIV 288 +NG+GER GN +L VI +K++ + + + +++ R S V+++ N ++ V Sbjct: 239 INGLGERCGNTNLISVIPVLKLKMGVNCGVSTESLRKLRRLSTFVNEMANQLPWQHQPFV 298 Query: 289 GSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE 348 G AFAH GIH V K YE + P S+G N ++ +++++GR+ + ++ ++ E Sbjct: 299 GQNAFAHKGGIHVSAVRKASHLYEHIDPASVG-NAQRVLVSNQAGRSNILAKLQQL---E 354 Query: 349 SEYNLDN--LYDAF--LKLADKKGQVFDYDLEALAFIGKQQ--EEPEHFRLDYFSV---Q 399 + +D+ + A +K + G F+ + + ++ + HF L F V + Sbjct: 355 PDAIVDDAAVVRAVQRIKEMEATGYAFEGADASFQLLLRRATGQFRRHFELVSFRVYDEK 414 Query: 400 SGSNDI--ATAAVKLACGEEVKAEAANGNGPVDAVYQAIN-------------RITEYNV 444 G ++ + A V++ + AA G+GPV+A+ +A+ R+T++ V Sbjct: 415 RGHDEAPESEATVQVRVNGRLLHTAALGSGPVNAMDKALRAALTGAYPGLEDMRLTDFKV 474 Query: 445 ELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAM 492 + L+ K + A+ +V I ++ R+++ VG++TD++E++ +A+ Sbjct: 475 RV----LSTKDATEAAV-RVLIESSDGVRKWNTVGVSTDVLEATYRAL 517 >UniRef50_A6FZR1 Homocitrate synthase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6FZR1_9DELT Length = 382 Score = 139 bits (349), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 108/354 (30%), Positives = 179/354 (50%), Gaps = 13/354 (3%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSS-PGDFESVQTIARQV 65 + D+TLR+G Q+ + KL IA L GVD +EVG PVSS ++ + + Sbjct: 3 LVDSTLREGLQSDTRPVDSARKLDIAALLAAFGVDCIEVGNPVSSERARADARRLAGLDL 62 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 ++RV A RC +DI A ++ ++ FI SP+ L +LDE+IE A+ Sbjct: 63 GSTRVLAHVRCHPEDIRAAVDT----GVDGLNLFIPCSPLLRHASLGRSLDELIEIAVGA 118 Query: 126 VKRARNYTDDVEF--SCEDAGRTPIADLARVVEAAIN-AGATTINIPDTVGYTMPFEFAG 182 ++ AR ++E + ED+ RTP+ +L R A + + + DTVG P Sbjct: 119 LELARALRPELELRITPEDSFRTPVPELERFCGAVTSRVRVDRVGLADTVGVAHPRAVEA 178 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + L +R ++D + H H+D G AV N+L A AGA V+ + G+GER G +LE Sbjct: 179 RFARLRQRF-DLD---LEFHGHNDTGCAVANALLAREAGATHVDVTVLGLGERNGITALE 234 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 + A+ V D VH + + + ++ V+ + IP N +VG+ +FAH +G+H + Sbjct: 235 GFVAALLV-HDPDAVHGRLRLELLPLLTRAVADAFGVEIPRNSCLVGANSFAHKAGVHTN 293 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNL 356 +L++R +YE + P+ +G+ + L +G + + R +G S L L Sbjct: 294 AMLRDRRSYEFVDPQLMGVERRLLAGHEMTGASVLGARAQALGLDLSPEQLRRL 347 >UniRef50_Q07179 Homocitrate synthase n=3 Tax=Rhodobacter RepID=NIFV_RHOCA Length = 382 Score = 139 bits (349), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 110/357 (30%), Positives = 169/357 (47%), Gaps = 16/357 (4%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + + + DTTLRDGEQ + S+ EK IA AL+R GV +EVG + ++ + Sbjct: 5 RTLALCDTTLRDGEQTAGVAFSLAEKKAIARALDRAGVAEIEVGIAAMGWAEVAEIRAVV 64 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 ++ ++ R D+D+A ++ R+H + TS + KLR D ++ Sbjct: 65 AEIAHATPVVWCRLRMHDLDMAQKT----GVKRVHFAVPTSTAQLEGKLRVDRDWILRET 120 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 +V A + V EDA RT L R+ E A AGA I DT+G P Sbjct: 121 AALVFCASDRGLQVSVGAEDASRTDPDFLIRLAEVAAAAGAIRFRIADTLGLLDPLGAFR 180 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 +++ L R+ I +H H+D G+A N++ A HAGA + +NG+GERAGN + E Sbjct: 181 LVAELSARI----SLPIEMHAHNDFGMATANTIMAAHAGATHLSVTVNGLGERAGNAACE 236 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVG-SGAFAHSSGIHQ 301 EV A++ + T ++ + S +V++ A K I G FAH SGIH Sbjct: 237 EVGAALEAG----GIDTGLDLCALPELSAVVAKASGRAFRAQKPITGDDWLFAHESGIHV 292 Query: 302 DGVLKNRENYE--IMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNL 356 D +LK + YE P G + Q+ + SG A ++ + E G + LD L Sbjct: 293 DAILKRADTYEDPRCAPARFG-RERQIVIGKHSGSAGLRAALLEAGLPADDAVLDRL 348 >UniRef50_P70728 Homocitrate synthase n=1 Tax=Azospirillum brasilense RepID=NIFV_AZOBR Length = 376 Score = 137 bits (345), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 108/355 (30%), Positives = 164/355 (46%), Gaps = 22/355 (6%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+ II DT RDGEQ + ++ EK+ IA AL+ GV +E+G P + E ++ Sbjct: 1 MAGSTIINDTHARDGEQTAGVAFTLDEKIAIAQALDEAGVAELEIGIPAMGREERERIRA 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 +A +R+ + C D D+ A S VA + + S +HI KL + + Sbjct: 61 VASLGLKARL--MVWCRMHDTDLKARSTAVAPSLS----VPVSDIHITKKLNGSRAWALR 114 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 VK AR++ +V ED+ R AD+ ++ AA A DT+G PF+ Sbjct: 115 EIERKVKTARDHGLEVSLGGEDSSR---ADMDFLIAAATVAQRPRFRFADTLGVLDPFQH 171 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 A + P I HT +LAAV GA V +NG+GERAGN Sbjct: 172 ARLHLTAAATDPEIG---YHAHTPRLANATAWVTLAAVLGGATHVNTTVNGLGERAGNAP 228 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV++++KV + ++ + + S LV + N P+ NK+IV F H +GIH Sbjct: 229 LEEVVVSLKV---LYGQDCGVDTRALGAISDLVERASNRPVAVNKSIVRDAVFTHEAGIH 285 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDN 355 DG+L +R I TP G ++ S A++ R E G ++ D+ Sbjct: 286 VDGLLTDRAPTRISTPPRWG-------ASTASCWASIPARGGEDGLRQLGIACDD 333 >UniRef50_Q1DCT2 2-isopropylmalate synthase/homocitrate synthase family protein n=3 Tax=Myxococcales RepID=Q1DCT2_MYXXD Length = 421 Score = 135 bits (339), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 110/366 (30%), Positives = 179/366 (48%), Gaps = 31/366 (8%) Query: 5 VIIFDTTLRDGEQALQ-ASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 V I D TLRDG QA S +V+EK + ++ +GV + +G P + P E V T+AR Sbjct: 30 VEINDETLRDGMQATAVTSPTVEEKRGLLELMQHIGVSAVSLGMPAAGPWALEEVVTLAR 89 Query: 64 QVKNSRV-----CALARCVEKDIDVAAESLKVA-EAFRIHTFIATSPMHIATKLRSTLDE 117 ++ + CA AR + DI E+++ A + +HTFI +SP+ + LD Sbjct: 90 HIREEALRLEPNCA-ARTLHSDIVPIVEAVQRAGQPIVVHTFIGSSPLRQCAEAWD-LDF 147 Query: 118 VIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMP 177 ++ + + A +V F ED R+ L + AA+ GA+ + + DTVG+ P Sbjct: 148 ILRSSTAAIDFAVRQGLEVAFITEDTTRSTPETLELLFRAAVEHGASRLVLCDTVGHATP 207 Query: 178 FEFAGIISGLYERVPNIDKAI-ISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERA 236 ++ + V + + + H H+D GLA+ N+L A+ AGA +V G GIGER Sbjct: 208 AGTRALVRWTRDLVERLGSPVKVEWHGHNDRGLALINALVALEAGATRVHGCGLGIGERT 267 Query: 237 GNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLV---SQICNMPIPANKAIVGSGAF 293 GN +E +++ +K+ I Q++ R V +Q+C +PIP N +VG AF Sbjct: 268 GNAPVELLLLNLKLLGWI--------DQDLTRLVDYVLTLAQVCRVPIPRNYPLVGEDAF 319 Query: 294 AHSSGIHQDGVLKNREN---------YEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEM 344 ++G+H ++K E Y + G Q QL L SG + V++ + Sbjct: 320 RTATGVHSAAIIKALERGDDWLADHIYSSVPAGEFGRRQ-QLELGPMSGMSGVRYWLMVR 378 Query: 345 GYKESE 350 G +E+E Sbjct: 379 GLQENE 384 >UniRef50_Q12122 Homocitrate synthase, mitochondrial n=109 Tax=cellular organisms RepID=HOSM_YEAST Length = 440 Score = 135 bits (339), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 98/359 (27%), Positives = 165/359 (45%), Gaps = 9/359 (2%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 + D+TLR+GEQ A ++K++IA AL+ GVD +E+ PV+S + + I + Sbjct: 39 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL 98 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 +++ RC D VA E+ + I TS ++ + + A+ ++ Sbjct: 99 KAKILTHIRCHMDDARVAVET----GVDGVDVVIGTSKFLRQYSHGKDMNYIAKSAVEVI 154 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 + ++ ++ FS ED+ R+ + DL + + G + I DTVG P + +I Sbjct: 155 EFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRT 214 Query: 187 LYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIM 246 L V I H H+D G A+ N+ A+ GAR ++ ++ GIGER G L +M Sbjct: 215 LKSVV----SCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGG-LM 269 Query: 247 AIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLK 306 A + V + +I LV+ + IP N I G AF H +GIH +L Sbjct: 270 ARMIVAAPDYVRSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILA 329 Query: 307 NRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLAD 365 N YEI+ P G+ + +G A+K R+D++ ++ + + KL D Sbjct: 330 NPSTYEILDPHDFGMKRYIHFANRLTGWNAIKSRVDQLNLNLTDDQIKEVTAKIKKLGD 388 >UniRef50_C5AK37 Isopropylmalate/homocitrate/citramalate synthase n=7 Tax=Proteobacteria RepID=C5AK37_BURGB Length = 456 Score = 134 bits (336), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 100/323 (30%), Positives = 158/323 (48%), Gaps = 13/323 (4%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 Q I D +LR+G Q +Q + +++ +A + GVD++E G P SP + E V+ + R Sbjct: 2 QANIIDCSLREGCQTIQCNFDIEQSEILARKIAEFGVDMIECGHPKISPYELERVRAVVR 61 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRST-LDEVIERA 122 V V A ARC +DID AES A + F + +P+ +ATK D+V+ Sbjct: 62 -VSPLPVLAHARCRSEDIDAVAES----GAAWVGMFASFNPVSLATKFGGMGKDQVLALF 116 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 ++ A++ V + EDAGRT +DL R+ + A+ AGA I D+VG +P E Sbjct: 117 EASIRYAKSRGLSVRATIEDAGRTEQSDLFRIYQTAVAAGADRICFADSVGALLPSETYD 176 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I++ L + H H+D GLA+ +SL A+ AG + + NGIGERAG Sbjct: 177 ILALLRHEFRQVQ---FEYHVHNDRGLALASSLEALRAGVEWISTSCNGIGERAGVTDTF 233 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 ++ ++ R + Q S+LV + + IVG FAH+S +H+ Sbjct: 234 QLAALLESRFGDASRRLDKARQ----LSELVRVFSRIDGSPMQPIVGDNVFAHASRLHRI 289 Query: 303 GVLKNRENYEIMTPESIGLNQIQ 325 K+ Y I +P G +++ Sbjct: 290 ACEKDASAYNIHSPALAGDAEVR 312 >UniRef50_D1PA75 (R)-citramalate synthase n=1 Tax=Prevotella copri DSM 18205 RepID=D1PA75_9BACT Length = 532 Score = 133 bits (334), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 135/518 (26%), Positives = 226/518 (43%), Gaps = 41/518 (7%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTI 61 +++ I D TLRDGEQ S EKL IA + L + VD +EV S G+ ++V Sbjct: 13 KEIEIMDCTLRDGEQTNGVSFLPHEKLMIARMLLHDINVDRIEVASARVSEGEKDAV--- 69 Query: 62 ARQVKNSRVCALARCVEK----------DIDVAAESLKVAEAFRIHTFIATSPMHIATKL 111 +R+C A+ + K D + + + + I+ S H +L Sbjct: 70 ------ARICRYAKTIGKLDSVEVLGFVDNNKSVDWIAECGGHVINLLAKGSYKHCTQQL 123 Query: 112 RSTLDEVIERAIYMVKRARNYTDDVEFSCED--AGRTPIAD-LARVVEAAINAGATTINI 168 + + +E + + A + V ED +G D L +++ + + Sbjct: 124 KMSPEEHLAHIKQTIGYALSKGFTVNLYLEDWSSGMRDSRDYLFMMMDELVKQPIKRFLL 183 Query: 169 PDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGA 228 PDT+G P + + + R PN + H H+D LAV NSLAAV +GA+ + Sbjct: 184 PDTLGILNPLQCVEYMRQMVRRYPN---SHFDFHAHNDYDLAVSNSLAAVLSGAKGLHVT 240 Query: 229 MNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIV 288 +NG+GER GN L V + + KD+ T I + S+LV + + N +V Sbjct: 241 VNGLGERCGNAPLASVQVIL---KDMFEAKTNIKEDRLNDISRLVEGYSGIAVAPNTPVV 297 Query: 289 GSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE 348 G F +G+H DG K++ + PE G ++ + L SG+A + ++E+G + Sbjct: 298 GDNVFTQVAGVHADGDNKDKLYCNDLVPERFGRHR-EYALGKNSGKANIVQNLNELGLEL 356 Query: 349 SEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPE-HFRLDYFSVQSGSNDIAT 407 + + +L D+K V DL + + PE +L + V + Sbjct: 357 TPEQTKAVTKRITELGDRKELVTQDDLPYIVSDVLKHGAPEDKVKLVSYMVSTSYGLKPI 416 Query: 408 AAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVK-------YSLTAKGHGK-D 459 A+VK+ + + ++G+G DA +A+ I Y V+L K Y +T G+ D Sbjct: 417 ASVKVEIEGKEYEDQSSGDGQYDAFVKALRNI--YKVKLGKTFPKLDNYQVTIPPGGRTD 474 Query: 460 ALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLN 497 AL Q I R + GL D E++ KA + ++N Sbjct: 475 ALVQTVITWREGDRIWRTRGLDADQTEAAIKATLKMIN 512 >UniRef50_Q97MC5 2-isopropylmalate synthase n=50 Tax=Bacteria RepID=LEU1_CLOAB Length = 558 Score = 132 bits (332), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 136/533 (25%), Positives = 226/533 (42%), Gaps = 61/533 (11%) Query: 12 LRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ---VKNS 68 LRDG QAL ++V EK+++ L +G +E+GFP +S ++E + + ++ Sbjct: 35 LRDGNQALPKPMNVDEKIKMFKMLVDIGFKEIEIGFPSASETEYEFTRKLIEDKLIPEDV 94 Query: 69 RVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI---YM 125 + L + E + E+LK + +H + +TS + + DEV AI M Sbjct: 95 TIQVLTQAREHLVKKTFEALKGVKTAIVHVYNSTSELQRRVVFKKDKDEVKSLAIKGAQM 154 Query: 126 VKRARNYTDD------VEFSCEDAGRTPIADLARVVEAAINAGATT------INIPDTVG 173 VK+ YT+ E+S E T + V EA +N + IN+P TV Sbjct: 155 VKKYSEYTEYSESKFVFEYSPESFTGTELDYALEVCEAVLNVWKPSKENKAIINLPSTVE 214 Query: 174 YTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIG 233 P +A I +++ N + I+S+HTH+D G +S + AGA +VEG + G G Sbjct: 215 MATPNIYADQIEWFCKKLLNRESVILSLHTHNDRGTCTASSELGILAGADRVEGTLFGNG 274 Query: 234 ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAF 293 ER GN IM + + V + + + + M + G F Sbjct: 275 ERTGNLD----IMNMALNMYSQGVDPELEFSNLNDIVEAYEECTKMVVHERHPYAGKLVF 330 Query: 294 AHSSGIHQDGV------LKNREN------YEIMTPESIGLNQIQ-LNLTSRSGRAAVKHR 340 SG HQD + LK +N Y + P +G + + + S+SG+ + Sbjct: 331 TAFSGSHQDAIRKGLKSLKEGKNKHWEVPYLAVDPHDLGREYEEIIRINSQSGKGGTAYI 390 Query: 341 MDEMGYKESEYNL---DNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYF- 396 M ES++ ++ F K+ KK D +L +EE R Y+ Sbjct: 391 M------ESDFGFILPKAMHPEFGKVIKKKSDELDCELSPEQIFKFFKEEYLENRSPYYL 444 Query: 397 ---------SVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELV 447 +++ N + AV G++ E GNGPVDA + A+N + + Sbjct: 445 KNYKIHSIQNIEEEKNTVDIEAVISVNGKDTSIEGV-GNGPVDAFFNAMNNKKYNGCKFI 503 Query: 448 KY---SLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLN 497 Y +L H K A+ V I + +++ GVG++ +I +S A+V LN Sbjct: 504 SYDEHALNIGSHSK-AVAYVQIES--QDKKYFGVGISDNIDTASINAIVSALN 553 >UniRef50_Q10Y65 2-isopropylmalate synthase n=1 Tax=Trichodesmium erythraeum IMS101 RepID=Q10Y65_TRIEI Length = 462 Score = 132 bits (331), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 104/323 (32%), Positives = 160/323 (49%), Gaps = 25/323 (7%) Query: 5 VIIFDTTLRDGEQ-ALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 V I D+TLR+G Q A + S ++ L+IA L +G+D++EV PV S E Q I R Sbjct: 2 VQIVDSTLREGRQTAPGINFSWEQSLKIAKLLHSLGIDIIEVCHPVVS---IEQKQ-IVR 57 Query: 64 QVKNSRVC---ALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 ++ S +C A AR DI E++K A + F+ + T+ R T+ ++ Sbjct: 58 EIVASNLCPVIAHARANLADI----EAVKETSAQWVGIFLGINEETRLTRARWTISKIFN 113 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 V A+ V ++ EDA RT L V AI AGA I DTVG P E Sbjct: 114 CIKESVMYAKTLGLKVRYTAEDASRTDYCLLKSVYSVAIEAGADCICFSDTVGIMEPNEV 173 Query: 181 AGIISGL---YERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 I L + VP + VH H+D GLA+ N+LAA AGA ++ ++NG+GER G Sbjct: 174 TETIEKLKSDFSTVP------LEVHFHNDRGLAMANALAASDAGAERISSSVNGLGERCG 227 Query: 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 +++ + + + + + + I RTS+ V+ P+ N+ I G AF H++ Sbjct: 228 ITDTLGLLVNLYYK----GLRSLPSGEIIQRTSKYVAAFSRYPVNFNQPISGGNAFIHTA 283 Query: 298 GIHQDGVLKNRENYEIMTPESIG 320 +HQ V ++ +Y + PE +G Sbjct: 284 HLHQKAVKRDPSSYSWILPEYVG 306 >UniRef50_B7G5N8 2-isopropylmalate synthase n=2 Tax=Bacillariophyta RepID=B7G5N8_PHATR Length = 581 Score = 130 bits (328), Expect = 9e-29, Method: Compositional matrix adjust. Identities = 127/511 (24%), Positives = 216/511 (42%), Gaps = 77/511 (15%) Query: 12 LRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGD---FESVQTIARQVKNS 68 +RDG Q S SV +KL+I L GVD +E G+P S+P D F +T + Sbjct: 7 VRDGTQGESVSASVDDKLKITRRLVAFGVDFVEAGWPGSNPKDAAFFTRAKTDLTHAERD 66 Query: 69 RVCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE----VIE 120 ++ A K + D ++L ++A + + LR+TLDE + + Sbjct: 67 KLVAFGSTRRKRVRANEDPQVQALLESQAPTVCIVAKAHAWQVTEILRATLDENLDMIRD 126 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 +V R D+E + + P + AA++ GA+ + DT G TMP+ Sbjct: 127 TVACLVAHGRVVMVDLEHALDGYATDPDY-VHACCRAAVDGGASVLVACDTNGGTMPWRV 185 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 ++ L + I +H H+D G+AV NSL A GA ++G +NGIGER GN Sbjct: 186 GTVVRELVDTY-GPQGVTIGMHAHNDCGMAVANSLTAAQYGAGLIQGTVNGIGERTGNAD 244 Query: 241 LEEVI--MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSG 298 L ++ +A+ V+ + H + + S+ V ++ N VGS AFAH G Sbjct: 245 LCAIVPSLALHVQAQL---HCRASLATLTSLSRFVDEVLNQTPNHAAPFVGSSAFAHKGG 301 Query: 299 IHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK----------- 347 +H + ++ +Y+ + PE +G N+ ++ ++ SGR + +M + G Sbjct: 302 LHVAAMERSPLSYQHIEPELVG-NEQRILISELSGRQNILGKMQQAGVDLGTSGSDRAVA 360 Query: 348 ------------------ESEYNLDNL-----YDAFLKLADKKGQVFDYDLEALAFIGKQ 384 E+ +L L Y ++ D QV+D ++++ + + Sbjct: 361 ILNRVKTLEAQGYTFEGAEASVHLMILHATKGYCPPFQVLDYSAQVYDANIDSATRVLRH 420 Query: 385 QEEPEHFRLDYFSVQ--SGSNDIATAAVKLACGEEV----------------KAEAANGN 426 E P+ D + G A A V + + + E ++GN Sbjct: 421 TESPDTDPTDSKKPRKAPGFGPTARATVNVRTMRPIEDGLESYLANLSPYQDRLEVSDGN 480 Query: 427 GPVDAVYQAINRITE------YNVELVKYSL 451 GPVDA+ A+ R + +VELV Y + Sbjct: 481 GPVDALANALMRALQPVHPILQHVELVDYKV 511 >UniRef50_C0Z7H0 Alpha-isopropylmalate/homocitrate synthase family protein n=5 Tax=Bacillales RepID=C0Z7H0_BREBN Length = 472 Score = 130 bits (327), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 100/327 (30%), Positives = 162/327 (49%), Gaps = 29/327 (8%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I D TLR+GEQ + ++K++I LE ++++EVG P S D E + +A+ + Sbjct: 6 ILDATLREGEQQAGVRFTCEDKIRILHLLESYQINLIEVGHPGISALDEEICRKVAQSAR 65 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE-VIERAIYM 125 +++ AR +++ A K A+A + + + + + I TK R + ++E+ Sbjct: 66 RAQILMHARATVEEVHAA----KRAKADWVGIWASINDVSIQTKFRHHEESYILEKVQQA 121 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 V A+ V F+ EDA RT ++ + AA+ AGA I++ DTVG P I++ Sbjct: 122 VIEAKKLGLQVRFTIEDASRTEWEKISSLGYAALQAGADRISLADTVGIWEPDTCKKIVT 181 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245 E I VH H+D GLA N+LAA+ AGA ++ + GIGERAG L ++ Sbjct: 182 RAIEEF----GCEIEVHLHNDFGLAQANALAAIDAGASVIDATILGIGERAGITDLIQLT 237 Query: 246 MAI-KVRKD-------ILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 +A+ K+R D I + AI +R +L + I G AF H+S Sbjct: 238 VALQKLRNDHRYSLDRIPELVQAIRLTTGYRPDEL------------RPITGQNAFTHTS 285 Query: 298 GIHQDGVLKNRENYEIMTPESIGLNQI 324 H V +N + YE + PE+IG ++ Sbjct: 286 AYHVQAVKRNSKAYEPLPPETIGRTRL 312 >UniRef50_C1XGU5 Isopropylmalate/homocitrate/citramalate synthase n=2 Tax=Meiothermus RepID=C1XGU5_MEIRU Length = 422 Score = 129 bits (323), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 96/356 (26%), Positives = 174/356 (48%), Gaps = 24/356 (6%) Query: 2 SQQVIIFDTTLRDGEQAL------QASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDF 55 + ++ I DTT RDG+Q+ + +++EK + L +GV E PV + Sbjct: 17 AHRIEIVDTTFRDGQQSPLLFDTEKYRFTLEEKKVLMTGLLELGVTHFEFFSPVVGVAEA 76 Query: 56 ESVQTI-----ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATK 110 + V+ + A K R A RC +DI+ A E+ ++ ++ SP+ Sbjct: 77 QDVRELIAHASALTQKPLRFLAHCRCNLQDIEQALET----GCNGLNLYLGVSPLAQQHN 132 Query: 111 LRSTLDEVIERAIYMVKRARNYTDD--VEFSCEDAGRTPIADLARVVEAAINAGATTINI 168 + +L+E ++ ++ R D + FS EDA RTP+ D+ R+ +A I T+ + Sbjct: 133 AQKSLEESVQLVQEVIATTRAAHPDLYIRFSAEDAFRTPLEDIFRLYDA-IYPYVNTLGM 191 Query: 169 PDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGA 228 PDTVG P + + +++ L +R PN+ + H H+D GLA+ N +AAV AG R V+ + Sbjct: 192 PDTVGIAEPEDVSAVVAQLRQRYPNV---ALECHFHNDRGLALANVIAAVRAGVRYVDAS 248 Query: 229 MNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIV 288 + G+ ER+G S+ V+ + R + N + + + L++ I +P + + Sbjct: 249 IWGLAERSGIPSVTGVLFNLSKRYP--EIAQQYNLSQCYPLNVLMASILGTLVPYTEPVS 306 Query: 289 GSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEM 344 + H++G+HQ VL ++ YE G+++ QL L SG + + + E+ Sbjct: 307 LTNR-THTAGVHQKAVLNEKKVYEAHNLHDFGVDKNQLLLGPLSGWNLIYYYLKEV 361 >UniRef50_A9VAW1 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VAW1_MONBE Length = 564 Score = 128 bits (322), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 103/381 (27%), Positives = 169/381 (44%), Gaps = 48/381 (12%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I DTTLR+GEQ + +++ IA L+ GVD +E+ P +S E + IA Sbjct: 40 IIDTTLREGEQFSSTDFTSHDRVYIAKLLDTFGVDYIELVNPFASHQAREDCRAIANLGL 99 Query: 67 NSRVCALAR--------CVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEV 118 +++ A R CVE ID + + +EA R H+ ++ V Sbjct: 100 KAKIVAHTRCHMDDVRACVETGIDGVSMYMATSEALRRHSH------------GKSVQAV 147 Query: 119 IERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 I+ A +++ ++ +V FSCED R+ +L + A G + + DTVG PF Sbjct: 148 IDSAREVIEFVKDNGMEVRFSCEDTFRSDRTELLDIYAAIDELGVNRVGLADTVGIATPF 207 Query: 179 EFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGN 238 + A ++ + + + I HTH+D G + N+L A+ AGA + + G+GER G Sbjct: 208 QVAETVAAVRSIIK--PETGIEFHTHNDTGCCIANALVALQAGATHINTCVLGVGERNGI 265 Query: 239 CSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSG 298 L +A D +V + + + + V+ + IP N I GS AF H +G Sbjct: 266 TPLGG-FLARMYTLDRESVKNKYDLKLLRHLEKYVAAAAKVQIPFNNYITGSSAFTHKAG 324 Query: 299 IHQDGVLKNRENYEIMTPESIGLNQ------------------IQLNLT-----SRSGRA 335 +H V+ + YE++ P+ G+ + + LNLT ++ Sbjct: 325 VHSKAVMSDPGAYEVINPDDFGVGRNIEIAHHLTGWNALKARSMDLNLTIPDDQIKAATK 384 Query: 336 AVKHRMDEMGYKESEYNLDNL 356 VKH + G K S+ LD L Sbjct: 385 MVKHYAADKGIKPSQ--LDQL 403 >UniRef50_C7LNR6 Pyruvate carboxyltransferase n=1 Tax=Desulfomicrobium baculatum DSM 4028 RepID=C7LNR6_DESBD Length = 373 Score = 127 bits (318), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 107/385 (27%), Positives = 188/385 (48%), Gaps = 23/385 (5%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 ++ DTTLR+G Q S+ + K++IA + MGV+ +E+G+ + G E V+ + + Sbjct: 1 MLIDTTLREGAQMFGTSIPQEAKIRIAGRIADMGVEEIEIGW-MGQEGLDEVVKALRGRG 59 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 + + C D+ AA L + I+ + S +HIA +LR+ D + Sbjct: 60 VTCDLSVWSPCRTVDVYRAA-GLSIDT---INIGLPVSDLHIAERLRTDRDGLTRMLRET 115 Query: 126 VKRARNY-TDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 V A + + ED R + A GA I + DT+G P A ++ Sbjct: 116 VGLAHSCGIRRISIGLEDVTRADQDFALSMARMAKELGAARIRLADTLGVMTPTRIAELV 175 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + V I++H H+D G+A N++ A+ AGA + ++ GIGER+G +LEEV Sbjct: 176 RFFAQSV----DMEIAIHCHNDFGMATANAITALEAGAHWADVSVLGIGERSGISALEEV 231 Query: 245 IMAIKVRK--DILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 +++ + DI +++ + LV++ +P+ N+ + G FA SG+H D Sbjct: 232 AGHLRLVQGYDIYDMNL------VRALCDLVAEYARIPVARNRPMSGGDIFAAESGLHVD 285 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G+LKN +E P G +I L L +++GR AV+ + ++G K +++ N+ D + Sbjct: 286 GILKNPALFEPYDPAQTGAKRI-LALGAKAGRGAVRTMLRQVGLKGPLHSIGNMVDTIRE 344 Query: 363 LADKKGQVFDY-DLEALAFIGKQQE 386 A + G+ +++ALA K QE Sbjct: 345 RAHRTGRPLTQGEVQALA---KHQE 366 >UniRef50_A4QAP0 2-isopropylmalate synthase n=225 Tax=cellular organisms RepID=LEU1_CORGB Length = 616 Score = 126 bits (317), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 141/546 (25%), Positives = 245/546 (44%), Gaps = 59/546 (10%) Query: 12 LRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ---VKNS 68 LRDG QAL +S + K ++ L +MG +EVGFP +S DF+ V+ I + + Sbjct: 74 LRDGNQALIDPMSPERKRRMFELLVQMGFKEIEVGFPSASQTDFDFVREIIEKDMIPDDV 133 Query: 69 RVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI---YM 125 + L + E I E+ + A+ +H + +TS + R D+V + A + Sbjct: 134 TIQVLVQAREHLIRRTFEACEGAKNVIVHFYNSTSILQRNVVFRMDKDQVKKLATDAAEL 193 Query: 126 VKR-ARNYTDD---VEFSCEDAGRTPIADLARVVEAAINAGATT------INIPDTVGYT 175 +K A++Y D ++S E T + VV+A + T IN+P TV Sbjct: 194 IKTIAQDYPDTNWRWQYSPESFTGTEVEYAKEVVDAVVEVMDPTPENPMIINLPSTVEMI 253 Query: 176 MPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGER 235 P +A I ++ V D I+S+H H+D G VG + AGA ++EG + G GER Sbjct: 254 TPNVYADSIEWMHRNVNRRDSIILSLHPHNDRGTGVGAAELGYMAGADRIEGCLFGNGER 313 Query: 236 AGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAH 295 GN L V +A+ + V ++ +I + V + +P G F Sbjct: 314 TGNVCL--VTLALNMLTQ--GVDPQLDFTDIRQIRSTVEYCNQLRVPERHPYAGDLVFTA 369 Query: 296 SSGIHQDGV------------------------LKNRE---NYEIMTPESIGLN-QIQLN 327 SG HQD V L++ E Y + P+ +G + + + Sbjct: 370 FSGSHQDAVNKGLDAMAAKVKPGANSTDVSWEELRDTEWEVPYLPIDPKDVGRDYEAVIR 429 Query: 328 LTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK-LADKKGQVFD----YDLEALAFIG 382 + S+SG+ V + M + ++ + A ++ + D +G + +D+ A ++ Sbjct: 430 VNSQSGKGGVAYIMKTDHGLQIPRSMQVEFSAVVQNVTDAEGGEVNSKAMWDIFATEYL- 488 Query: 383 KQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEY 442 ++ E L + Q+ + D + A + G++V + +GNGP+ A A+ ++ Sbjct: 489 ERTAPVEQIALRVENAQTENEDASITAELIHNGKDVTVD-GHGNGPLAAYANALEKLG-I 546 Query: 443 NVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRA 502 +VE+ +Y+ A+ G DA ++A NGR+ GVG+A I +S KA+ +N RA Sbjct: 547 DVEIQEYNQHARTSGDDAEAAAYVLAEVNGRKVWGVGIAGSITYASLKAVTSAVN---RA 603 Query: 503 AEVEKE 508 +V E Sbjct: 604 LDVNHE 609 >UniRef50_Q0W3Q1 2-isopropylmalate synthase n=8 Tax=Archaea RepID=Q0W3Q1_UNCMA Length = 468 Score = 126 bits (317), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 105/348 (30%), Positives = 163/348 (46%), Gaps = 15/348 (4%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 S ++ I DTT+RDG Q + KLQI L MGV+ +E V + D ++ +++ Sbjct: 16 SAEIKISDTTIRDGCQMPGVVMKKSHKLQIFEYLHEMGVEKLETF--VYNDRDKDACKSM 73 Query: 62 ARQ-VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKL-RSTLDEVI 119 + V AR DID E LKV ++ S HI K+ + E Sbjct: 74 MDYGYEFPEVTGWARANPADID---EVLKVDGIRETGILMSVSDSHIFDKMGLKSYAEAE 130 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGA-TTINIPDTVGYTMPF 178 ++ + ++ A ++ ED R + V+ I T I I DT+GY +PF Sbjct: 131 QKYLKALQYAIDHGLKTRCHIEDTSRANYEFVYPFVQKLIEIDPDTIIRICDTLGYGIPF 190 Query: 179 EFAGIISGLYERVPNIDK---AIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGER 235 G+ V N+ + I +H HDD GL +GN+LA + GA GIGER Sbjct: 191 PGYEEPYGIPTVVKNLKEMGVKHIEMHVHDDFGLGIGNTLAGLWYGADWASLTFLGIGER 250 Query: 236 AGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAH 295 AGN LE+++ + R + + N Q+ ++ + Q + +P NKAIVG F+H Sbjct: 251 AGNTELEKIMAFLITRVEGFEKY---NLQKATEFAEYMEQEIGLRVPRNKAIVGKNIFSH 307 Query: 296 SSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDE 343 SGIH G++KN YE PE +G + L + SG ++ +++E Sbjct: 308 ESGIHTAGIIKNPFTYEPFPPELVG-GKRNLMIGDTSGTDVIRLKVEE 354 >UniRef50_Q1IYY1 Homocitrate synthase n=1 Tax=Deinococcus geothermalis DSM 11300 RepID=Q1IYY1_DEIGD Length = 389 Score = 126 bits (316), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 99/381 (25%), Positives = 174/381 (45%), Gaps = 28/381 (7%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I D+TLR+GEQ + + +K++IA L+ G + +EV P+ ++ + Sbjct: 17 IIDSTLREGEQFARGNFKTGDKIEIARLLDAFGAEFLEVTTPMVGAQTQADIRRLTSLGL 76 Query: 67 NSRVCALARC----VEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 N+++ RC V++ +D+ + L + TS ++ ++I+ A Sbjct: 77 NAKILTHVRCHLEDVQRAVDLGVDGLDL--------LFGTSSFLREFSHGKSIAQIIDTA 128 Query: 123 IYMVKRARNYTDDVE--FSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 ++ + D+E FS ED R+ ADL V A + G + + DTVG P + Sbjct: 129 SEVIGWIKQNHPDLEIRFSAEDTFRSEEADLMAVYRAVSDLGVHRVGLADTVGVATPRQ- 187 Query: 181 AGIISGLYERVPNIDKAI-----ISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGER 235 +Y V + K I I H H+D G AV N+ A+ AGA ++ + GIGER Sbjct: 188 ------VYTLVREVRKVIHAECGIEFHGHNDTGCAVSNAYEAIEAGATHIDTTILGIGER 241 Query: 236 AGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAH 295 G L +A D + N + + +L++++ ++PIP N + G A+ H Sbjct: 242 NGITPLGG-FLARMFTFDPQGLIDKYNLELLPELDRLIARLVDLPIPWNNYLTGEFAYNH 300 Query: 296 SSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDN 355 +G+H + N YE + P G+ + + +G+ A+ H+ E+G E L Sbjct: 301 KAGMHLKAIYLNPGAYEAIPPSVFGVGRRIQAASKVTGKHAIAHKARELGLHYGEDALRR 360 Query: 356 LYDAFLKLADKKGQVFDYDLE 376 + D LA+ +G++ D LE Sbjct: 361 VTDHIKALAE-EGELDDAHLE 380 >UniRef50_A6DIP7 2-isopropylmalate synthase n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DIP7_9BACT Length = 554 Score = 126 bits (316), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 129/521 (24%), Positives = 239/521 (45%), Gaps = 64/521 (12%) Query: 12 LRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA--RQVKNSR 69 LRDG QAL L++++K L ++G +E+GFP +S D++ + + + + + Sbjct: 33 LRDGNQALPDPLTLEQKKIYFDILVKIGFKEIEIGFPSASKDDYDFCRHLIDNKVIPDDV 92 Query: 70 VCALARCVEKDIDVAA-ESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVK- 127 + ++ D+ V ++L+ +H ++ATS +H L + EV E V+ Sbjct: 93 MISVLVPARPDLVVKTMDALRDVPKATVHFYVATSDLHREHVLGKSHQEVFEMCTATVQS 152 Query: 128 ------RARNYTDDVEFSCEDAGRTPIADLARVVEAAINAG------ATTINIPDTVGYT 175 + + T +EFS E+ T + V + I +N+P TV Sbjct: 153 IKEEASKLKESTFYLEFSPEEFTDTDLDFAVEVCDHVIEQWQPAADEKVILNLPATVERR 212 Query: 176 MPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGER 235 P +A +I L++R ++AIIS+H H+D+G AV ++ A+ AGA +VEG + G GER Sbjct: 213 PPTHYADMIE-LFQRKLKSEQAIISLHAHNDMGCAVASTQLAIQAGAHRVEGTLFGQGER 271 Query: 236 AGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAH 295 +GN L +++ ++ L + T ++ ++ ++ +S++ NMP VGS F+ Sbjct: 272 SGNVDLITLVLNLQY----LGIDTGLDFSDLMNITEQISELTNMPPHERHPYVGSLVFSA 327 Query: 296 SSGIHQDGVLKN--------------RENYEIMTPESIGL---NQIQLNLTSRSGRAAVK 338 SG HQD + K+ + Y + P +G N I++N S+SG+ + Sbjct: 328 FSGSHQDAIHKSTLRKDELMETFGRWKIPYLHIDPADVGREFENLIRIN--SQSGKGGIA 385 Query: 339 HRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQ-----EE----PE 389 H + E E+N+ F+++ D +V Y E + Q+ EE P+ Sbjct: 386 HII------EKEHNIK--LPRFVQV-DFAKRVQAYAEEVSREVSTQEVWKVFEEAYIAPK 436 Query: 390 HFRL---DYFSV-QSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINR--ITEYN 443 + +L +Y+ ++I A +++ E A GNGP+ A A+ + I ++ Sbjct: 437 NPKLVLNNYWPYPDEDQSEIVNAKIEVEFKGETFTHEATGNGPISAFVAALKKLDIPDFV 496 Query: 444 VELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDI 484 +E +A+ + + + NG G G ++I Sbjct: 497 LEHFGEDSIGDSAQAEAVSSISVKNSDNGSVHIGFGYHSNI 537 >UniRef50_Q7M8U7 HOMOCITRATE SYTHASE 1 n=1 Tax=Wolinella succinogenes RepID=Q7M8U7_WOLSU Length = 376 Score = 126 bits (316), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 96/341 (28%), Positives = 157/341 (46%), Gaps = 14/341 (4%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + I DTTLRDGEQA + + +EK +IA L G D +E+G P + E ++ I Sbjct: 2 ITINDTTLRDGEQAPTVAFTQEEKCEIAKLLYEAGADELEIGIPAMGEAEREDIRAILSL 61 Query: 65 VKNSRVCALARCVEKDIDVA-AESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 R+ + R + D++ + A +K + I S +A K R +V+ Sbjct: 62 GLPLRLMSWNRATQSDLEASLACGMKA-----VDLSIPVSTKMVAAKFRGKYAKVLSNLE 116 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 + A+ V ED R L V+ A+ GA + DTVG P + Sbjct: 117 ETLTIAKKEGLFVCVGMEDTSRANARFLKEVIALAMERGADRVRFCDTVGILTPLQTYRA 176 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 I L + +H H+D G+AV NS+A + AGA+ V + GIGERAGN E+ Sbjct: 177 IRSLRRHC----TLPVEMHCHNDYGMAVANSIAGIEAGAQSVNTTVIGIGERAGNAGFEQ 232 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 V++++ + + ++ + Q V++ + + +VGS F H SGIH DG Sbjct: 233 VLLSLIGQ---FGQNRTLDSTILKALVQKVAKAAGVALAPTAPVVGSRLFWHESGIHADG 289 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEM 344 K+ YE +PE +G ++ + + SG A + + + + Sbjct: 290 NQKSEGLYEPFSPELVGASR-EYPIGKHSGSANLIYHLKQF 329 >UniRef50_C5S831 2-isopropylmalate synthase n=20 Tax=Bacteria RepID=C5S831_CHRVI Length = 534 Score = 125 bits (315), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 145/508 (28%), Positives = 228/508 (44%), Gaps = 23/508 (4%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTI 61 ++V+I DTTLRDGEQ S + EKL +A + LE++ VD +EV S G+ +V I Sbjct: 21 RRVLIMDTTLRDGEQTQGVSFAPAEKLNLAKVLLEQVRVDRIEVASARVSSGEASAVAQI 80 Query: 62 ARQVKNSRVCALARCVEK----DIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + +R L VE D + + + A ++ S H +L TLDE Sbjct: 81 ---IDWARERGLVERVEVLGFVDGGASVDWICGAGGQVLNLLAKGSEKHCRGQLGKTLDE 137 Query: 118 VIERAIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTVGY 174 + A++ V ED R + +VE + G +PDT+G Sbjct: 138 HAADVRATIAAAQSRGLRVNLYLEDWSNGYRDNPDYVYGLVERLADVGIGHFMLPDTLGV 197 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 P + IS + R P++ H H+D GLA N LAAV AGA V +N +GE Sbjct: 198 MTPDQVFTAISDMVGRFPSLQ---FDFHPHNDYGLATANVLAAVQAGAAAVHCTVNCLGE 254 Query: 235 RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFA 294 RAGN SL EV A+ +R D L+ I+ + R S+LV I N IVG+ F Sbjct: 255 RAGNASLAEV--AVNLR-DQLDCALGIDETHLARVSELVESFSGKRISDNAPIVGADVFT 311 Query: 295 HSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLD 354 ++GIH DG K + ++PE + + L +G+A++ ++ + + SE N Sbjct: 312 QTAGIHADGDKKGSLYHSRLSPERFARRR-KYALGKLAGKASLAKNLERLDIELSEENQR 370 Query: 355 NLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLAC 414 + ++L D K + DL + + ++ +H L +V S + + A +++ Sbjct: 371 KVLQRIVELGDSKKTITTEDLPFIIAEVLESKDYDHAELLSCTVSSSLDLESMAGIRIRL 430 Query: 415 GEEVKAEAANGNGPVDAVYQAINRITEYN----VELVKYSL-TAKGHGKDALGQVDIVAN 469 GE+V GNG DA A+ RI + L+ Y + KG DAL + I Sbjct: 431 GEQVFTGTGTGNGGFDAFTNALGRILKRQGLTLPPLIDYEVRIPKGGRTDALTECSITWQ 490 Query: 470 YNGRRFHGVGLATDIVESSAKAMVHVLN 497 G+ + V ++ A + +LN Sbjct: 491 TERGELRTRGVHANQVFAAIGATMRMLN 518 >UniRef50_C8WRC1 2-isopropylmalate synthase n=14 Tax=Bacteria RepID=C8WRC1_ALIAD Length = 564 Score = 125 bits (315), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 131/521 (25%), Positives = 233/521 (44%), Gaps = 40/521 (7%) Query: 12 LRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT-IARQVKNSRV 70 LRDG QAL ++++EKL L +G +EVGFP +S +FE V+T I R + S V Sbjct: 38 LRDGNQALIVPMNLEEKLAYFQLLVEIGFKEIEVGFPAASDTEFEFVRTLIERDLVPSDV 97 Query: 71 C--ALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKR 128 L + + I+ E+++ A+ +H + +TS R+ DE++ A+ ++ Sbjct: 98 TIQVLTQSRDHIIERTFEAIRGAKRAIVHLYNSTSVAQREQVFRADKDEIVNIAVTGAEQ 157 Query: 129 ARNYTDDV------EFSCEDAGRTPIADLARVVEAAINAGATT------INIPDTVGYTM 176 R+ ++S E T + + A ++ T IN+P TV +M Sbjct: 158 IRDLARTTPGNFFFQYSPESFTGTELDFALEICNAVLDVWKPTPDRKVIINLPATVELSM 217 Query: 177 PFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERA 236 P +A I + +R+ D ++SVH H+D G V + A+ AGA ++EG + G GER Sbjct: 218 PHVYASQIEYMGKRLARRDAIVLSVHPHNDRGTGVAAAELAMLAGAERLEGTLFGNGERT 277 Query: 237 GNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHS 296 GN + V +A+ + + ++ + V + M + G F Sbjct: 278 GNVDI--VTLALNLYSH--GIDPGLDFSNLPAIQARVEALTKMQVSRRHPYAGELVFTAF 333 Query: 297 SGIHQDGVLKNRENYEIMTPESIGLNQIQLN--------------LTSRSGRAAVKHRMD 342 SG HQD + K + E +PE + + ++ + S+SG+ + + ++ Sbjct: 334 SGSHQDAIAKGMKWREEKSPEHWTVPYLPIDPKDIGREYEGDIIRINSQSGKGGIGYVLE 393 Query: 343 EM-GYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSG 401 + G+ + L A +++D++ + D A F+ + + L + Sbjct: 394 QSHGFDLPPKMREQLGYAVKRVSDREQKELSADEIAEIFMREFVNLGQPLDLVELTGTDA 453 Query: 402 SNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINR---ITEYNVELVKYSLTAKGHGK 458 A + GE V+ E A GNG +DA+ A+ I N+ +++L G G Sbjct: 454 RGSHRVRATVVWQGETVEIEGA-GNGRLDALCHALEEGLGIRVANLTYKEHALEV-GSGS 511 Query: 459 DALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNI 499 A+ + V + G G G+ TDI+E+SAKA+V +N + Sbjct: 512 RAVAYIS-VDDEEGNTHFGCGVDTDIMEASAKALVSAVNRM 551 >UniRef50_B2KBD6 Pyruvate carboxyltransferase n=7 Tax=Bacteria RepID=B2KBD6_ELUMP Length = 416 Score = 125 bits (314), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 108/350 (30%), Positives = 169/350 (48%), Gaps = 28/350 (8%) Query: 1 MSQQVI-IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP--GDFES 57 MS ++I I D T RDG Q + L+ +K + + L+ MG+ E GFP + + Sbjct: 1 MSDKLIYIVDVTNRDGVQTSRLGLAKLQKTLVNIYLDEMGITQSEFGFPTTQHEINYLNA 60 Query: 58 VQTIARQ--VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKL--RS 113 +A + +K + + R +E D+ +A ++ V + ++ I+TS I K R Sbjct: 61 NLDLAERGGIKKTVLSGWMRALESDVVLAFKN--VPKLKTVNLSISTSDQMIQGKFGGRK 118 Query: 114 TLDEVIERAIYMVKRARNYTDD-VEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTV 172 T ++I + VK+A + V + EDA RT L AA AGA + DT+ Sbjct: 119 TRKDIINQMTAAVKKAYECGAELVGVNSEDASRTDQEYLVEFALAAKAAGAKRLRYCDTL 178 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAI---ISVHTHDDLGLAVGNSL----AAVHAGAR-Q 224 GY P Y R+ ++ K + +H H+DLG+AV NS+ A+ G Sbjct: 179 GYDSP-------DVAYSRLNDLAKRTCLDLEMHFHNDLGMAVANSVRGAQGAIDGGVNAY 231 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDI---LNVHTAINHQEIWRTSQLVSQICNMPI 281 + A+NG+GER+GN L ++A+ + I+ +IW ++ S +PI Sbjct: 232 INTAVNGMGERSGNADLACCVLAVLKSSGFSGKYKIDPDIDMSKIWPLAKYTSYSFGVPI 291 Query: 282 PANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSR 331 P N VG AFAH SGIH DG LK+R NYE+ E +G + ++ T R Sbjct: 292 PINYPAVGGNAFAHESGIHADGALKDRRNYELYDYEELGRGEPEVIETGR 341 >UniRef50_C6A4Y6 2-isopropylmalate synthase 1 n=1 Tax=Thermococcus sibiricus MM 739 RepID=C6A4Y6_THESM Length = 418 Score = 125 bits (313), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 94/349 (26%), Positives = 175/349 (50%), Gaps = 17/349 (4%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 ++V++ D T+R+G+Q + E + IA AL+ +G+D +E+ P S D E+ + + Sbjct: 37 PERVVLHDATIREGQQMPGVAFKRDEIVMIAKALDELGIDRIEL-IPFLSKDDEEAAKEL 95 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 N+++ + ++D D+A LK+ + F+ +P +E+IER Sbjct: 96 VDMGLNAKLLSFVSWKKEDTDLA---LKLDLEGVVLDFVG-NPWQGKVFWNLKPEEIIER 151 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 + A+++ V D + P+ + + V+A A I I DT G +P+ Sbjct: 152 GVNAALYAKDHGLYVVAMPWDDFKAPLDFVEQNVKALTEAHVDRITICDTYGDALPWAME 211 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 ++ L + DK + +H H+D GLA +L AV +G + +NG+GER G SL Sbjct: 212 YVMKRLKKAA---DKTPLELHIHNDFGLATAGALVAVASGVEGLHVTVNGLGERVGLLSL 268 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EE+ +A++ +L V T IN ++++ S++V +I + + NK IVG+ F +++G Sbjct: 269 EEIAVALEF---LLGVKTNINLEKLYEISKIVEEISKVKVAVNKPIVGANQFKYTAGWIT 325 Query: 302 DGVLKNRENYEI-----MTPESIGLNQIQLNLTSRSGRAAVKHRMDEMG 345 K RE ++ PE++G Q+ ++ SG + V ++ E+G Sbjct: 326 WMHRKAREAGKLTGMLPFMPEAVG-RQLDYVVSKGSGASFVAEKLAELG 373 >UniRef50_C8W3E1 Pyruvate carboxyltransferase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8W3E1_DESAS Length = 287 Score = 123 bits (309), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 86/250 (34%), Positives = 137/250 (54%), Gaps = 14/250 (5%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 +V I DTTLRDGEQ+ + S KEK++IA L+ +GV+ +E+G P + +++ +IA Sbjct: 3 KVCIVDTTLRDGEQSPGVAFSAKEKIKIAQYLDLLGVEQIELGIPAMGGIEVDAISSIAS 62 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 +R+ R DI A+ S +V +H S + I KL + V++ Sbjct: 63 LDLKARLTTWNRLHLSDIR-ASLSCRVKN---LHICAPVSDIQIEYKLNKSRLWVLDCLK 118 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINA---GATTINIPDTVGYTMPFEF 180 ++ A++Y + EDA R AD ++E A+ A GA + DTVG PF Sbjct: 119 RAIRYAKDYGCWISVGAEDASR---ADPEFLLEYALLAQEMGAERLRYADTVGVLEPFST 175 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 +S L +++ K + H H+D GLA N++AAV+AG R ++ +NG+GERAGN + Sbjct: 176 YRELSWLKDKL----KIELEFHGHNDFGLATANTVAAVNAGVRFIDVTVNGLGERAGNAN 231 Query: 241 LEEVIMAIKV 250 +EEV+ AI++ Sbjct: 232 MEEVVAAIRM 241 >UniRef50_Q12166 2-isopropylmalate synthase 2, mitochondrial n=8 Tax=cellular organisms RepID=LEU9_YEAST Length = 604 Score = 123 bits (309), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 135/544 (24%), Positives = 222/544 (40%), Gaps = 52/544 (9%) Query: 8 FDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKN 67 T LRDG Q+L +SV +K + L +G +EV FP +S DF+ + + Sbjct: 63 LSTDLRDGNQSLPDPMSVAQKKEYFHKLINIGFKEIEVSFPSASQTDFDFTRYAVENAPD 122 Query: 68 S-RVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 + L + E I E+L A+ IHT++ATS M + +E I +A+ Sbjct: 123 DVGIQCLVQSREHLIKRTVEALTGAKRATIHTYLATSDMFREIVFNMSREEAISKAVEAT 182 Query: 127 KRARNYTDD----------VEFSCEDAGRTPIADLARVVEAAINAGATT------INIPD 170 K R T D EFS E TP + EA A T N+P Sbjct: 183 KLVRKLTKDDPSQQATRWSYEFSPECFSDTPGEFAVEICEAVKKAWEPTEENPIIFNLPA 242 Query: 171 TVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMN 230 TV P +A I + +K IS H H+D G V + + AGA +VEG + Sbjct: 243 TVEVASPNVYADQIEYFSTHITEREKVCISTHCHNDRGCGVAATELGMLAGADRVEGCLF 302 Query: 231 GIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGS 290 G GER GN L V M + + V ++ ++ S++V + +PIP G Sbjct: 303 GNGERTGNVDLVTVAMNMYTQ----GVSPNLDFSDLTSISEIVHRCNKIPIPPRAPYGGE 358 Query: 291 GAFAHSSGIHQDGVLKN---------------RENYEIMTPESIGLN-QIQLNLTSRSGR 334 + SG HQD + K R Y + P+ IG + + + + S+SG+ Sbjct: 359 LVVSAFSGSHQDAIKKGFAIQNKKQAQGETRWRIPYLPLDPKDIGRDYEAVIRVNSQSGK 418 Query: 335 -AAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQ-----QEEP 388 A M +G + + K AD G+ + E + + K+ E Sbjct: 419 GGAAWVIMRSLGLDVPRPMQVDFSNTLQKNADALGR--ELKSEEITKLFKETYNYNNNEH 476 Query: 389 EHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVK 448 + L + V+ + + ++ ++V GNGP+ ++ A++ + + + Sbjct: 477 IYVTLLNYEVKKLNPERRALVGQVEINDKVVNIEGYGNGPISSLVDALSNLLNVKLSVQN 536 Query: 449 YSLTAKGHGKDA-------LGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWR 501 YS + G G L + + N+ GVG++ D ++S KA+ +NNI Sbjct: 537 YSEHSLGSGSATQAASFINLSYIKDINNHATSNMWGVGVSEDTGDASIKAVFATVNNIIH 596 Query: 502 AAEV 505 + +V Sbjct: 597 SGDV 600 >UniRef50_B8FYI5 Pyruvate carboxyltransferase n=5 Tax=Bacteria RepID=B8FYI5_DESHD Length = 557 Score = 122 bits (307), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 128/534 (23%), Positives = 238/534 (44%), Gaps = 67/534 (12%) Query: 12 LRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ---VKNS 68 LRDG QAL +S++EKL+ L ++G +EVGFP +S ++ ++T+ Q ++ Sbjct: 38 LRDGNQALVVPMSLEEKLEYYHMLLKIGFKEIEVGFPAASETEYAFLRTLIEQNLIPEDV 97 Query: 69 RVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKR 128 + L + + I+ ++L + +H + +TS + + +E++E A+ + Sbjct: 98 TIQVLTQSRDHIIEKTFKALVGVKKAVVHLYNSTSVAQREQVFKMSREEIVEIAVSGARL 157 Query: 129 ARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATT------INIPDTVGYTM 176 + Y + E +S E T + + ++ T IN+P TV +M Sbjct: 158 LKKYAAETEGNFQFEYSPESFTGTEMEFALEICNQVLDVFEPTPENKVIINLPATVSLSM 217 Query: 177 PFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERA 236 P +A I + E + D I+S+H H+D G AV ++ + AG +++EG + G GER Sbjct: 218 PHVYASQIEYMSEHLKYRDNVILSLHPHNDRGTAVADAELGLLAGGQRIEGTLFGNGERT 277 Query: 237 GNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHS 296 GN + V +A+ + V +N + + + M + + G FA Sbjct: 278 GNVDI--VTLALNLFSH--GVDPGLNFASMLEITAKYEALTRMKVHDRQPYGGKLVFAAF 333 Query: 297 SGIHQDGV---LKNRENYE---------IMTPESIGL----NQIQLNLTSRSGRAAVKHR 340 SG HQD + +K RE +E ++ P+ IG + I++N S+SG+ + + Sbjct: 334 SGSHQDAITKGIKWREEHECHYWNVPYLLIDPQDIGREYEGDVIRIN--SQSGKGGIAYM 391 Query: 341 MDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEH----FRLDYF 396 + E Y LD L K + F Y ++ ++ ++ PE F +Y Sbjct: 392 L------EQHYALD--------LPAKMREAFGYKVKNVSDNLHKELMPEEIKDIFFKEYV 437 Query: 397 SVQSG---------SNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAIN-RI-TEYNVE 445 ++++ ++D V L E++ + G+G +DA+ A+ R+ Y+ Sbjct: 438 NIENPIKFLNFHFLNHDDFQTTVTLEFKGEIQELSGEGDGRLDAISNALQARLGLSYSNL 497 Query: 446 LVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNI 499 + K G A+ V + +G G G+ TDI SS KA++ +N + Sbjct: 498 IYKEHALELGSKSQAVSYVGVTGP-DGVIHWGCGIHTDIFTSSVKALISAINTM 550 >UniRef50_A8TLL5 Homocitrate synthase n=1 Tax=alpha proteobacterium BAL199 RepID=A8TLL5_9PROT Length = 385 Score = 122 bits (307), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 107/349 (30%), Positives = 169/349 (48%), Gaps = 14/349 (4%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 V+I D+TLR+GEQ + A S KL+IA AL GV+ +EV P +S TIA Sbjct: 4 SDVVIVDSTLREGEQFVHADFSRDAKLEIARALTSFGVNYLEVTSPAASRRSRTDAATIA 63 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 + V A RC + D +A ++ A +H +ATSP+ A + EV+ A Sbjct: 64 NAGLPAMVAAHIRCHKDDAAIAIDTGVGA----LHMVMATSPILRAASHGKAIAEVVRIA 119 Query: 123 IYMVKRARNYTDDVE--FSCEDAGRTPIADLARV-VEAAINAGATTINIPDTVGYTMPFE 179 + + RN ++E FS EDA R P+ DL V + + + DT G P Sbjct: 120 AEVGEFVRNRAPNIELRFSSEDAFRCPLNDLMNVYLPLSELRLFDRFGLADTTGAATPDR 179 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 A +++ L + I H H+D+G A+ N+ AA GA + + G+GER G Sbjct: 180 VAEVVNLLRR----LTTTPIEFHGHNDIGCAIANAHAAAMNGATHINTTVLGLGERNGIT 235 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 LE +I A+ D E+ + V+++ + +P N+ +VG AF+H +G+ Sbjct: 236 PLEGLI-AVMYAADRGRTMAQFQLSELPALCRRVAELAGVAVPFNQVLVGESAFSHKAGM 294 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSR-SGRAAVKHRMDEMGYK 347 H V + +YE M P GL + ++ ++ R +G AV+ R D +G + Sbjct: 295 HTKAVHNDPRSYEAMDPSDFGLTR-EIAISHRLTGWNAVRVRADALGLR 342 >UniRef50_C0GSN3 Pyruvate carboxyltransferase n=1 Tax=Desulfonatronospira thiodismutans ASO3-1 RepID=C0GSN3_9DELT Length = 399 Score = 121 bits (303), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 103/372 (27%), Positives = 178/372 (47%), Gaps = 23/372 (6%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 ++ DTTLR+G+Q LS+++K I L R+G+D +E G V + E++ ARQ Sbjct: 33 MLIDTTLREGDQRYGLYLSLEQKKVIVDGLHRLGLDELETG-SVGRDEELETLIKYARQH 91 Query: 66 KNS-RVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 S ++ + C ++++ A +SL + I + S +HI +L LD A+ Sbjct: 92 HGSTKISLWSPCRIQELEYA-DSL---DPDIISAALPVSDLHIEKRL--GLDRC--GALR 143 Query: 125 MVKRARNYTDDVE----FSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 +++R TD ++ ED R R A + G + + DT+G P E Sbjct: 144 LLERTLAGTDKLKAKLSLGLEDFSRADREFALRAALMARDLGVWRVRLSDTLGVMEPGEL 203 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 + E++ ++ H H+D G+A N+L A+ G V+ ++ GIGERAG Sbjct: 204 MEAVRPFREKL----DISLAFHGHNDFGMATANALTALSCGVDYVDVSLLGIGERAGIAR 259 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV+ + K H + Q + S V+ + + I ++A++G F SG+H Sbjct: 260 LEEVLTFLVYNKG----HAGYDVQSLPELSTCVAGLAGVHINPDRAVLGRQLFHCESGLH 315 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 D + K+ + +E P +G+ Q +++L +SG AV+ ++ EMG +L+ L Sbjct: 316 ADALYKSFDLFEPFEPHKMGM-QRRISLGRKSGAGAVRGKLMEMGVNPDFVDLEGLVRDV 374 Query: 361 LKLADKKGQVFD 372 + A KG D Sbjct: 375 RRAASIKGSPLD 386 >UniRef50_P06208 2-isopropylmalate synthase n=109 Tax=cellular organisms RepID=LEU1_YEAST Length = 619 Score = 120 bits (301), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 131/541 (24%), Positives = 220/541 (40%), Gaps = 47/541 (8%) Query: 8 FDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKN 67 T LRDG Q+L +SV++K + L +G +EV FP +S DF+ + + Sbjct: 64 LSTDLRDGNQSLPDPMSVEQKKEYFHKLVNIGFKEIEVSFPSASQTDFDFTRYAVENAPD 123 Query: 68 S-RVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 + L + E I E+L A+ IHT++ATS M + +E I +A+ Sbjct: 124 DVSIQCLVQSREHLIKRTVEALTGAKKATIHTYLATSDMFREIVFNMSREEAISKAVEAT 183 Query: 127 KRARNYTDD----------VEFSCEDAGRTPIADLARVVEAAINAGATT------INIPD 170 K R T D EFS E TP + EA A T N+P Sbjct: 184 KLVRKLTKDDPSQQATRWSYEFSPECFSDTPGEFAVEICEAVKKAWEPTEENPIIFNLPA 243 Query: 171 TVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMN 230 TV P +A I + +K IS H H+D G V + + AGA +VEG + Sbjct: 244 TVEVASPNVYADQIEYFATHITEREKVCISTHCHNDRGCGVAATELGMLAGADRVEGCLF 303 Query: 231 GIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGS 290 G GER GN L V M + + V ++ ++ +V + +P+ G Sbjct: 304 GNGERTGNVDLVTVAMNMYTQ----GVSPNLDFSDLTSVLDVVERCNKIPVSQRAPYGGD 359 Query: 291 GAFAHSSGIHQDGV-----LKNREN----------YEIMTPESIGLN-QIQLNLTSRSGR 334 SG HQD + L+N++ Y + P+ IG + + + + S+SG+ Sbjct: 360 LVVCAFSGSHQDAIKKGFNLQNKKRAQGETQWRIPYLPLDPKDIGRDYEAVIRVNSQSGK 419 Query: 335 -AAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAF---IGKQQEEPEH 390 A + +G A AD G+ D + F E+ + Sbjct: 420 GGAAWVILRSLGLDLPRNMQIEFSSAVQDHADSLGRELKSDEISKLFKEAYNYNDEQYQA 479 Query: 391 FRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYS 450 L ++V+ + ++ G+++ GNGP+ ++ A++ + + Y+ Sbjct: 480 ISLVNYNVEKFGTERRVFTGQVKVGDQIVDIEGTGNGPISSLVDALSNLLNVRFAVANYT 539 Query: 451 LTAKGHGKDALGQVDIVANY-----NGRRFH-GVGLATDIVESSAKAMVHVLNNIWRAAE 504 + G G I +Y N + + GVG++ D+ +SS +A+ +NNI + + Sbjct: 540 EHSLGSGSSTQAASYIHLSYRRNADNEKAYKWGVGVSEDVGDSSVRAIFATINNIIHSGD 599 Query: 505 V 505 V Sbjct: 600 V 600 >UniRef50_B3PEP5 2-isopropylmalate synthase n=90 Tax=Bacteria RepID=B3PEP5_CELJU Length = 673 Score = 119 bits (299), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 128/528 (24%), Positives = 233/528 (44%), Gaps = 46/528 (8%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ- 64 I T LRDG QAL +SV+ KL++ L +G +E+GFP +S D+ + + + Sbjct: 150 IWMSTDLRDGNQALIDPMSVQTKLRMFKELVAIGFKEIEIGFPSASEIDYNFTRMLIEEN 209 Query: 65 --VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 + + L + I+ +SL+ A +H + +P + + V + A Sbjct: 210 LIPDDVTIEVLVQARYDLIEKTVQSLRGARRAILHMYNPLAPAFRKIVYNTDKEGVKKIA 269 Query: 123 IYMVKRARNYTDD-------VEFSCEDAGRTPIADLARVVEAAINAGATT------INIP 169 + + + T ++S E T I + V +A + + +N+P Sbjct: 270 LQGTQWCKELTAQAPEVDWTFQYSPEVFSSTEIEFVKEVCDAVVEIWNPSPQKKIILNLP 329 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 TV P +A I ++ + D +ISVH H+D G AV + AV AGA +VEG + Sbjct: 330 ATVEMNTPNTYADQIEWIHRNIHRRDSIVISVHPHNDRGTAVAAAELAVMAGADRVEGCL 389 Query: 230 NGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVG 289 G GER GN L V +A+ + VH ++ +I + +L + +P+ G Sbjct: 390 FGNGERTGNVDL--VTLALNLYSQ--GVHPGLDFSDIDKVRKLHEECTQLPVHPRHPYAG 445 Query: 290 SGAFAHSSGIHQDGVLKN---RENYEIMTPESIGLNQIQLN--------LTSRSGRAAVK 338 F SG HQD + K ++ + + ++ LN + ++SG+ V Sbjct: 446 ELVFTAFSGSHQDAIKKGFAVQKKDTLWEVPYLPIDPADLNRSYDAVVRVNAQSGKGGVS 505 Query: 339 HRMDEMGYKESEYNLDNLYDAFL-KLADKKGQVFDYDLEALAFIGKQQ----EEPEHFRL 393 + + + L + + + K++D G+ + +A I ++ P ++ Sbjct: 506 FLLQQEAGLQLPRRLQIEFSSVVQKVSDSTGK--EVKASDIARIFNEEYFAVNSPITYQS 563 Query: 394 DYFSVQSGSN--DIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSL 451 F+ Q ++ DI A E+ + +GNGP+DA AI++ + V ++ Y Sbjct: 564 SKFTEQDDTHQVDIVIHAQHQNKTVEI---SGSGNGPIDAAAHAISQFIDTEVNVIDYHE 620 Query: 452 TAKGHGKD--ALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLN 497 + G G D A+ V+I NG+ +GVG +I+ S+ KA+++ +N Sbjct: 621 HSVGEGSDVVAVTYVEIKVK-NGKPVYGVGQDRNIITSAVKALINGVN 667 >UniRef50_B8FRV4 2-isopropylmalate synthase n=2 Tax=Desulfitobacterium hafniense RepID=B8FRV4_DESHD Length = 404 Score = 119 bits (299), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 89/355 (25%), Positives = 165/355 (46%), Gaps = 18/355 (5%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + Q++ I D TLRDGEQ S ++K++IA L +GV+ +E G P S D ++++ Sbjct: 27 LPQKIEIHDATLRDGEQTPGVVFSKEDKVRIAELLAEVGVERIEAGMPAVSKDDAQAIEE 86 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 IA++ ++ R + +D+D A + A+ + + + T + + E Sbjct: 87 IAKRNLGPKIMVFCRAMREDVDRAVDC--GADGIVLEAPSGYPKLKYQFASKWTEESLTE 144 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVV-EAAINAGATTINIPDTVGYTMPFE 179 + + A+ V + D R + L R++ A ++ + DT G P Sbjct: 145 AVVNTINYAKEKGLFVNYFPFDTTRAELPFLKRLLTNVTTQAKPDSVTVVDTTGSITPTA 204 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 ++ + E + + VHTH+D GL + AAV G + V +NG+GER GN Sbjct: 205 MRFLVRQVRETI----ALPLEVHTHNDFGLGTATTFAAVEEGVQVVHSCINGLGERTGNT 260 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 +LEE+ + +K+ I N Q++ SQ V ++ + NK +VG F G+ Sbjct: 261 ALEEIALGLKLLYGI--ELPKFNFQKLSELSQEVQRMSGKTLAQNKPVVGLLPFTREIGL 318 Query: 300 HQDGVLKNRENYEI----MTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESE 350 +K E+Y P+ +G ++++ + +SG+ +V +++ G K +E Sbjct: 319 G----MKVLEDYPTAVFPFMPDFVG-QKMKIVMGKKSGKESVLMKLEAAGLKANE 368 >UniRef50_A1KBD3 2-isopropylmalate synthase n=14 Tax=Bacteria RepID=LEU1_AZOSB Length = 572 Score = 119 bits (297), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 137/542 (25%), Positives = 232/542 (42%), Gaps = 65/542 (11%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +++ + T LRDG QAL ++ + K+++ L +G+ +EV FP +S DF+ V+ Sbjct: 35 ITRPPVWMSTDLRDGNQALFEPMNSERKMRMFKMLVEIGLKEIEVAFPAASQTDFDFVRE 94 Query: 61 I---ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMH---IATKLRST 114 + + + L + I+ ES++ A+ +H + A +P + R+ Sbjct: 95 LIEGGHIPDDVTIEVLTQARPHLIERTFESVRGAKRAIVHVYNAVAPNFRRIVFDTDRAG 154 Query: 115 LDEV-IERAIYMVKRA-RNYTDDVEF--SCEDAGRTPIADLARVVEAAINAGATT----- 165 + ++ ++ A Y V+ A R D F S E T + V A I T Sbjct: 155 VKQIAVDSARYFVEMAARQPGTDFTFQYSPEVFSGTELDFAVEVANAVIEVWQPTPQQKC 214 Query: 166 -INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 IN+P TV + P +A I ++ + D ++SVH H+D G AV + AV AGA + Sbjct: 215 IINLPATVEMSTPNVYADQIEWMHRHLARRDSVLLSVHPHNDRGTAVAAAELAVMAGADR 274 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 VEG + G GER GN L V +A+ + VH ++ I ++ V +PI Sbjct: 275 VEGCLFGNGERTGNVDL--VTLALNLYSQ--GVHPGLDFSRINEVARTVEHCTQLPIHPR 330 Query: 285 KAIVGSGAFAHSSGIHQDGVLKN----------RENYEIMTPESIGLN-QIQLNLTSRSG 333 VG F SG HQD + K Y + P +G + + + + S+SG Sbjct: 331 HPYVGDLVFTAFSGSHQDAIKKGFAVQQPDAVWEVPYLPVDPADLGRSYESIIRVNSQSG 390 Query: 334 RAAVKHRMDEMGYKESEYNL-------DNLYDAFLKLADKKGQVFD-------YDLEALA 379 + + + + E+EY L A ++ D++G ++ E LA Sbjct: 391 KGGIAYLL------EAEYGLVMPRRLQVEFSAAIQRITDERGTELSAGDIWRAFEEEYLA 444 Query: 380 FIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRI 439 + EH ++ Q S + A V+ + GNGP+DA A++ Sbjct: 445 -VAAPYAYVEHHLAEHGGQQGISLTVEEAGVR-------RVLRGVGNGPIDAALHALDA- 495 Query: 440 TEYNVELVKYSLTAKGHGKD--ALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLN 497 L+ Y A G G D A+ +++ G GVG+ +IV +S A+V L+ Sbjct: 496 ---GAVLLGYEERAIGQGGDARAVAYIELADGEGGGSTFGVGIHANIVTASVLAIVSALD 552 Query: 498 NI 499 + Sbjct: 553 RL 554 >UniRef50_Q7VH30 2-isopropylmalate synthase n=16 Tax=Bacteria RepID=LEU1_HELHP Length = 558 Score = 117 bits (293), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 129/532 (24%), Positives = 231/532 (43%), Gaps = 55/532 (10%) Query: 12 LRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ---VKNS 68 LRDG QAL +S++EK+ L ++G +EVGFP +S ++ ++T+ + + Sbjct: 37 LRDGNQALITPMSLEEKITFFKLLLKVGFKEIEVGFPAASETEYRFLRTLIEEDLIPDDV 96 Query: 69 RVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEV----IERAIY 124 V L + E I ESL+ + +H + +TS R + DE+ E AI Sbjct: 97 SVQVLTQAREHIIKKTFESLEGCKNAIVHVYNSTSYAQREQVFRKSKDEIKHIACEGAIC 156 Query: 125 MVKRARNYTDDV--EFSCEDAGRTPIADLARVVEAAINAGATT------INIPDTVGYTM 176 + + A + E+S E T + V A I+ T IN+P TV ++ Sbjct: 157 LKESAAATKGNFRFEYSPESFSGTEVDYALEVCNAVIDIFEPTLEKKLIINLPVTVEMSL 216 Query: 177 PFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERA 236 P +A + + + + N + +IS+H H+D G A+ ++ + AGA ++EG + G GER Sbjct: 217 PHIYASQVEYMSKHLKNRENVLISLHPHNDRGCAIADAELGLLAGADRIEGTLFGNGERT 276 Query: 237 GNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHS 296 GN + + +A+ + V ++ I + ++ M + + G FA Sbjct: 277 GNVDI--ITLAMNMHSH--GVDPKLDFSNIPSICDVYEKVTKMQVYERQPYSGKLVFAAF 332 Query: 297 SGIHQDGVLK----NREN--------YEIMTPESIG--LNQIQLNLTSRSGRAAVKH--- 339 SG HQD + K ++E+ Y + P+ +G + + S+SG+ + + Sbjct: 333 SGSHQDAIAKGMAYHKEHNLSTWSVPYLPIDPKDVGRVYESDVIRINSQSGKGGIAYILH 392 Query: 340 -----RMDEMGYKESEYNLDNLYDAFLK--LADKKGQVFDYDLEALAFIGKQQEEPEHFR 392 + + +E Y + N+ D K D+ ++F D L Q+ F Sbjct: 393 HHYGVNLPPLFREEFSYYVKNISDKAHKELSPDEICEIFQNDFVNLNNTLCVQD----FH 448 Query: 393 LDYFSVQSGSNDIATAAVKLACGEEVKAE---AANGNGPVDAVYQAINRITEYNVELVKY 449 + + S + L E K + GNG +D++ A+ + E++ Y Sbjct: 449 FTHIDSKP-SQEFNVKLHILYAKENSKTQQEITGKGNGRLDSIANALREHLNLDFEIIDY 507 Query: 450 SLTA--KGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNI 499 S + KG A+ V I + G++ GVG+ DI+ +S +V LN I Sbjct: 508 SEHSLKKGSTSQAVSYVQIES--KGKKCFGVGIDNDIITASIYGLVSALNRI 557 >UniRef50_Q7X1M2 Homocitrate synthase (Fragment) n=1 Tax=Leptospirillum ferrooxidans RepID=Q7X1M2_9BACT Length = 304 Score = 117 bits (292), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 88/298 (29%), Positives = 135/298 (45%), Gaps = 17/298 (5%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 + DTT+RDG Q+ K+ I L R+GV +EVG P + E ++ + Sbjct: 19 VFVDTTIRDGGQSPGVFFDRPTKMVIVTTLSRIGVQEIEVGTPCLGDHEIEDLRALLSLP 78 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAF-RIHTFIATSPMHIATKLRSTLDEVIERAIY 124 + R +E D + A + F R+H TS H A+ +++ER Sbjct: 79 VPVELFPWLRPLEADFESA-----LGLGFKRVHVSFPTSDAHRASVQNMGRPDIVERVRK 133 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 V R V EDA R P+ L + A +G + DTVG P E Sbjct: 134 TVLRMTGEGCRVSIGLEDASRAPMDFLKEFIAAVRESGGIRVRYCDTVGKHHPAE----- 188 Query: 185 SGLYERVPNIDKA--IISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + ER+ + K I +H H+DLG+A N+++A H+GAR + + G+GERAGN ++E Sbjct: 189 --IIERISELSKEGLPIEIHCHNDLGMATANTVSACHSGARYLSTTVTGVGERAGNAAME 246 Query: 243 EVIMAIKVRK--DILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSG 298 EV A+ + L +AI+ + S+ + + + IVGS F HSSG Sbjct: 247 EVAFALACERGDPSLPESSAIDLPGLAHISRWLYGAIRRTLSPYRPIVGSRIFHHSSG 304 >UniRef50_B1I1Z4 Pyruvate carboxyltransferase n=1 Tax=Candidatus Desulforudis audaxviator MP104C RepID=B1I1Z4_DESAP Length = 301 Score = 115 bits (287), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 83/246 (33%), Positives = 122/246 (49%), Gaps = 8/246 (3%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 QV + DTTLRDGEQ S +EK+ +A AL+R+GV+++E G P + ++V+ + Sbjct: 3 QVFLVDTTLRDGEQTPGLVFSTEEKVAVASALDRLGVELIEAGIPAMGVDEQKAVRAVLG 62 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 +RV A R DI E+ A + S +H+ KL T ++ R Sbjct: 63 AGLRARVLAWNRAHPSDI----EASLACGATCLQISFPVSDIHLQHKLGRTRSWLLARLE 118 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 ++ A +V EDA R A L + A AGA + DTVG PF Sbjct: 119 EVMALAVAPGREVAVGAEDASRADPAFLRLFAKKAEEAGACRLRYCDTVGVLDPFRSRDA 178 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 +S L ++ NI + H H+D G+A N+LAAV GA ++ +NG+GERAGN SL Sbjct: 179 VSDLTHKL-NIP---LEFHAHNDFGMATANTLAAVKGGAAYLDVTVNGLGERAGNASLSA 234 Query: 244 VIMAIK 249 V ++ Sbjct: 235 VARGLR 240 >UniRef50_A8L551 2-isopropylmalate synthase n=38 Tax=Bacteria RepID=LEU1_FRASN Length = 565 Score = 114 bits (286), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 133/529 (25%), Positives = 219/529 (41%), Gaps = 56/529 (10%) Query: 12 LRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ---VKNS 68 LRDG QAL ++ K+Q+ L MG +EVGFP +S DF+ V+ + + Sbjct: 44 LRDGNQALIDPMTPSRKMQLFELLVAMGYKEIEVGFPAASQTDFDFVRQLIEDDLIPDDV 103 Query: 69 RVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKR 128 + L + E+ I+ SL ++ IH + +TS + V + A+ + Sbjct: 104 TIQVLTQAREELIERTVTSLVGSDRALIHLYNSTSTLQRRVVFGLDRAGVTDIAVQGARW 163 Query: 129 ARNYTDDV--------EFSCEDAGRTPIADLARVVEAAINAGATT------INIPDTVGY 174 Y + + ++S E T + V EA ++ A T +N+P TV Sbjct: 164 CAQYAEKLLEGTDVRWQYSPESFTGTELDYALEVCEAVMDVWAPTPDNPVVLNLPATVEM 223 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 + P +A I + + D ++S+H H+D G AV + V AGA +VEG + G GE Sbjct: 224 STPNVYADQIEWMSRNLTRRDAVVLSLHPHNDRGCAVAAAELGVMAGADRVEGCLFGNGE 283 Query: 235 RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFA 294 R GN L + M + + + I+ +I + V +P+ G + Sbjct: 284 RTGNVCLVTLGMNLFSQ----GIDPMIDLSDIDGVRRTVEYCNQLPVHPRHPYGGDLVYT 339 Query: 295 HSSGIHQDGVLKNRE------------NYEIMTPESIGLN-QIQLNLTSRSGRAAVKHRM 341 SG HQD + K E Y + P+ +G + + + + S+SG+ V + M Sbjct: 340 AFSGSHQDAIKKGFEAMERTGQTLWEVPYLPIDPKDVGRSYEAVIRVNSQSGKGGVAYLM 399 Query: 342 DEMGYKESEYNLD---NLYDAFLKLADK----------KGQVFDYDLEALAFIGKQQEEP 388 +SEY LD L F + K GQ+++ G Sbjct: 400 ------KSEYALDLPRRLQIEFSGVVQKHTDDAGGEVTAGQLWEIFTREYRPEGGDPAAS 453 Query: 389 EHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVK 448 + SG+ D T +V+L E V +GNGP+DA A++ V ++ Sbjct: 454 LELLGSRTTAASGARDEVTVSVRLDGTETVI--TGSGNGPIDAFVAALSE-RGVPVRVLD 510 Query: 449 YSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLN 497 Y+ A G G DA + GVG+ +IV +S +A+V +N Sbjct: 511 YNEHALGSGADARAAAYLEVAVGETVLWGVGIDPNIVTASLRAVVSAVN 559 >UniRef50_C7IGD9 Homocitrate synthase n=1 Tax=Clostridium papyrosolvens DSM 2782 RepID=C7IGD9_9CLOT Length = 274 Score = 114 bits (285), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 79/250 (31%), Positives = 123/250 (49%), Gaps = 14/250 (5%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M ++ I DTTLRDGEQ + S +K+++A ++ G+ +E G P + E++ Sbjct: 1 MKEKKYIIDTTLRDGEQTPGYAFSKAQKVELAKVMDDAGIYQIEAGIPAMGNYEKETISE 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKL---RSTLDE 117 I Q KN+ + R DI+ + + IH S +HI +KL + L Sbjct: 61 IMSQRKNALISTWNRMSRDDINNSFD----CHPDIIHITAPISYIHIYSKLNKNKKWLRN 116 Query: 118 VIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMP 177 ++ ++M K + Y V F EDA R I + + + G ++ DTVG P Sbjct: 117 TLQECVFMAKD-KGYEVTVGF--EDASRADITFIISMANLLADMGVKSVRFADTVGVLTP 173 Query: 178 FEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 I + E N+D + +H H+DLG+A+ NSL A AGA ++ + GIGERAG Sbjct: 174 ARTYQCIREIKE---NVDIPV-GIHAHNDLGMALANSLIAAKAGALYIDTTIGGIGERAG 229 Query: 238 NCSLEEVIMA 247 NC L + I+A Sbjct: 230 NCDLYQFILA 239 >UniRef50_B2AHM5 2-isopropylmalate synthase n=69 Tax=cellular organisms RepID=LEU1_CUPTR Length = 569 Score = 112 bits (280), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 129/524 (24%), Positives = 230/524 (43%), Gaps = 51/524 (9%) Query: 10 TTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK--- 66 T LRDG QAL ++ KL++ L ++G+ +EV FP +S DF+ V+ + + + Sbjct: 36 TDLRDGNQALIEPMNPARKLRLFEQLVKIGLKEIEVAFPAASQTDFDFVRMLIEERRIPD 95 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 + + L + E I ES++ A +H + +P ++ DE+ A+ Sbjct: 96 DVTIVVLTQSREDLIRRTVESVRGAARATVHLYNPIAPAWRRIVFNASRDEIKAVAVSGT 155 Query: 127 KRARNYTDDV-------EFSCEDAGRTPI---ADLARVVEAAINAGA---TTINIPDTVG 173 + + TD + E+S E + +++ V AA AG +N+P TV Sbjct: 156 RLIKALTDAMPETAWTYEYSPETFSLAELDFSLEVSDAVSAAWQAGPGRPMILNLPTTVE 215 Query: 174 YTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIG 233 + P FA I ++ R+ ++SVH H+D G AV + A+ AGA +VEG + G G Sbjct: 216 CSTPNVFADQIEWMHRRLARRAHIVLSVHPHNDRGTAVAAAELALMAGADRVEGCLFGNG 275 Query: 234 ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAF 293 ER GN L V +A+ + V ++ +I Q V +P+ VG F Sbjct: 276 ERTGNVDL--VTLALNLYTQ--GVAPELDFSDIDAVRQCVEHCNQLPVHPRHPYVGDLVF 331 Query: 294 AHSSGIHQDGVLKNREN----------YEIMTPESIGLN-QIQLNLTSRSGRAAVKHRMD 342 SG HQD + K Y + P +G + + + S+SG+ + + ++ Sbjct: 332 TAFSGSHQDAIRKGFAQQQPDAIWEVPYLPIDPADLGRSYDAVIRVNSQSGKGGMAYLLE 391 Query: 343 EMG--YKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQS 400 ++ Y ++ A + D G + + L + +++ L Y S Q Sbjct: 392 QVHGLYLPRRLQIE-FSRAVQAMTDDTG--LEASADDLYGLFRREYLARETPLRYVSHQL 448 Query: 401 GSNDIATAAVKLACGEEVKAEA----ANGNGPVDAVYQAIN---RITEYNVELVKYSLTA 453 S+ AT A + E + GNGP+DA A++ R+ +Y+ ++++TA Sbjct: 449 ASD--ATGATAITVQMERDGQPCTVRGTGNGPIDAFIDALDLPVRVMDYH----EHAMTA 502 Query: 454 KGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLN 497 + A V++ + F G G+ +V +S +A+V +N Sbjct: 503 GADARAAC-YVEVRVGDSPTGF-GAGIDASLVTASLRAVVSGVN 544 >UniRef50_B0PEC7 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PEC7_9FIRM Length = 403 Score = 112 bits (279), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 97/372 (26%), Positives = 164/372 (44%), Gaps = 18/372 (4%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I D TLRDGEQ L+ +K+ +A + +G+ +E G P S D +V I ++ Sbjct: 32 IHDVTLRDGEQQAGLVLTCDQKIALAEKMAELGIHRIEAGMPAVSAEDARAVSEIVKRRL 91 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 + + ARC+ D+ AA+ I I ++ I +L++ +E ++ Sbjct: 92 PTEIFGFARCMVDDVKRAAD----CGVSGIVIEIPSNEEMIREAYGWSLEKAVELSVKAT 147 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVV-EAAINAGATTINIPDTVGYTMPFEFAGIIS 185 K A+ F D R I + +++ + A + + + DT+G P +I Sbjct: 148 KAAQGAGLYTVFFPIDMTRANIDWVLKLIGQVAADGHMDALAVVDTMGGLAPHTVPYLID 207 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245 + R IDK + VH HDD GL V NS+ + AGA V ++ GERAGN + E + Sbjct: 208 AIKSR---IDKP-LEVHFHDDFGLGVANSIMGLAAGADVVHTTISACGERAGNAAYEHLA 263 Query: 246 MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVL 305 +A+ + +++ +I+ S+L+ ++P+ N ++G F SGI G Sbjct: 264 LALLT---MYGYDLGLDYSKIYSLSKLLRSFIDLPVRGNMGVIGDRVFDIESGIVA-GWY 319 Query: 306 KNRENYEIM-----TPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 KN +N + PE G ++ L SG ++ D + K + +L Sbjct: 320 KNVKNTNPLLVTPYLPELTGHPGTEVVLGKHSGGPSIDCWADRLHIKLDKEQKSDLLGQI 379 Query: 361 LKLADKKGQVFD 372 A KKG D Sbjct: 380 KLAACKKGNTLD 391 >UniRef50_D1U2X4 Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio aespoeensis Aspo-2 RepID=D1U2X4_9DELT Length = 377 Score = 110 bits (276), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 101/364 (27%), Positives = 168/364 (46%), Gaps = 32/364 (8%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 ++ DTTLR+G Q A ++ + I L +GV+ +E+G+ V G V+T+ ++ Sbjct: 1 MLIDTTLREGAQLFGAYFTLDTREAIIAGLLDLGVEEIELGW-VGQEGLETLVRTMRKRA 59 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 +R+ + C E D+ AA L V ++ + S H+ +L V+ER Sbjct: 60 GATRLSVWSPCREADVRAAA-GLPVDC---VNIGVPVSDAHMEKRLGMDRQAVLERITST 115 Query: 126 VKRARNY-TDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 V AR V ED R+ + A AGA+ + + D++G P +I Sbjct: 116 VLAARLMDVSAVSVGLEDVSRSDLGFALTAALTAAEAGASRVRLSDSLGILTPVRMQALI 175 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 L+ +ID ++VH HDD G+A N++ A+ AGA + ++ GIGER+G + EE Sbjct: 176 D-LFRPALDID---LAVHCHDDFGMATANAVTALDAGADYADASVLGIGERSGIAATEE- 230 Query: 245 IMAIKVRKDILNVHTAINHQ----EIWRTSQL------VSQICNMPIPANKAIVGSGAFA 294 L H +N +RT L VS+ +PIP K+I G FA Sbjct: 231 ----------LAAHLCLNGNNSPCRPYRTDGLRALCRFVSKAAGVPIPRTKSIAGDDIFA 280 Query: 295 HSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLD 354 SG+H + K+ + +E P IG + ++ + +SGR AV + + + + + Sbjct: 281 CESGLHAHALSKSPDLFEPYDPARIGAGR-RIAVGGKSGRGAVVNALADFNLHCPDTAIP 339 Query: 355 NLYD 358 NL + Sbjct: 340 NLVN 343 >UniRef50_Q00853 Homocitrate synthase subunit alpha n=8 Tax=Clostridium RepID=NIFVA_CLOPA Length = 269 Score = 108 bits (271), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 84/243 (34%), Positives = 117/243 (48%), Gaps = 8/243 (3%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I DTTLRDGEQ +LSV++K++IA + MGV +E G P + SV IA Sbjct: 5 IVDTTLRDGEQKAGIALSVQDKVEIAKIISEMGVHQIEAGIPAMGGDEKISVSKIAALGL 64 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 S++ A R KDID + E +H S + I TKL V E V Sbjct: 65 PSKIAAWNRMSTKDIDTSIE----CGVDIVHISSPVSDLQIKTKLEKDRKWVAENLKRTV 120 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 A +V ED+ R + L ++ E G + DTVG P E I Sbjct: 121 IYALEKDCEVTVGLEDSSRADLNFLIQLCEMIFALGVKRVRYADTVGIMEPKELYSQIKK 180 Query: 187 LYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIM 246 + ++VP ID I +H H+D G+A+ NS AA AGA+ + + G+GERAGNC + + Sbjct: 181 IRDKVP-ID---IEIHVHNDFGMAISNSFAAFKAGAKFADCTITGMGERAGNCDFLKFVK 236 Query: 247 AIK 249 I+ Sbjct: 237 VIQ 239 >UniRef50_D1WUS8 2-isopropylmalate synthase n=2 Tax=Streptomyces RepID=D1WUS8_9ACTO Length = 359 Score = 108 bits (271), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 105/338 (31%), Positives = 155/338 (45%), Gaps = 30/338 (8%) Query: 37 RMGVDVMEVGFPVSSPG--DFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAF 94 R GV+++EVG VS P D E V V R L V +D A +L AE Sbjct: 20 RTGVELVEVGM-VSGPDSKDAELVLATHEAVTPERSMTL--VVVRDRRQVARALDEAERL 76 Query: 95 ---RIHTFIATSPMHIATKLRSTLDEVIER-AIYMVKRARNYTDDVEFSCEDAGRTPIAD 150 I I TS H KL S + ++ A +++A+ V FS ED RTP Sbjct: 77 GVRHIMYSIPTSEEHAQLKLDSASPKFLQALARSAIQQAKERGFHVTFSGEDGARTPRER 136 Query: 151 LARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLA 210 L V A AGA + +TV Y P++ +I+ L ID + I +H+H+ LGLA Sbjct: 137 LVPYVAAGFAAGADRFRLAETVAYLSPWQMEEVIADLT----AIDGSEIEIHSHNMLGLA 192 Query: 211 VGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTS 270 V NSLAAV AGAR + + GIGER GN L E++ +++V L+ T + + S Sbjct: 193 VANSLAAVRAGARWISATVGGIGERGGNAPLAELLTSLRV----LHGDTRFDLTHLTELS 248 Query: 271 QLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTS 330 ++ + + A H+ G L + + YE + E +G N +L + + Sbjct: 249 RIALRGAGL----GDAFQSGPTTPHAFAYELPGQLSHPQAYETLPAELVG-NSRELRVRT 303 Query: 331 RSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK-LADKK 367 R A V+ + + G LD DAF LA+++ Sbjct: 304 RLTTALVRWALTDSG-------LDVDVDAFTPWLAERQ 334 >UniRef50_Q1NS12 Pyruvate carboxyltransferase n=2 Tax=delta proteobacterium MLMS-1 RepID=Q1NS12_9DELT Length = 363 Score = 108 bits (271), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 104/341 (30%), Positives = 164/341 (48%), Gaps = 31/341 (9%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR--- 63 + D+TLR+G Q + LS + ++++A L MG++ +EVG P+ P D E Q + R Sbjct: 4 LIDSTLREGLQTVGLDLSQERQVELAGELAAMGIEELEVG-PLR-PDDDEVGQLLNRCRH 61 Query: 64 QVKNSRVCALARCVEKDIDVA----AESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 Q +R+ RC DI+ A E L ++ I S + + KL+ V Sbjct: 62 QAGVARLAIWCRCRAADIERALAWQPEVLALS--------IPISRLQMQVKLQRDEAAVK 113 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE 179 E ++R R + EDA R LA +V A GA I + DTVG P E Sbjct: 114 ELVTAALRRTRGRVGYLSLGLEDATRAEPRFLAEMVRLAKREGAHRIRLADTVGIATPAE 173 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 + ++ R + I VHTH+D G+A N++AA+ AGA + + G+GERAG Sbjct: 174 ISELVR--LVRDCGGRRLAIGVHTHNDFGMAGANAIAALAAGADWADVTLLGLGERAGLA 231 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQI---CNMPIPANKAIVGSGAFAHS 296 LEEV + +R+ T + QL +++ C PI + + +VGS FA Sbjct: 232 RLEEVAAYLALRRQRPYQLTGL--------PQLCARLAGFCGQPIASRQPVVGSDIFACE 283 Query: 297 SGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAV 337 +G+H + ++ YE P +G N+ QL +++GR A+ Sbjct: 284 TGLHLAALQQDPATYEPFEPALVG-NRRQLLYGTKTGRQAL 323 >UniRef50_B1QUV5 Homocitrate synthase 1 n=2 Tax=Clostridium butyricum RepID=B1QUV5_CLOBU Length = 265 Score = 108 bits (270), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 76/248 (30%), Positives = 121/248 (48%), Gaps = 14/248 (5%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M + V I DTTLRDGEQ+ + ++++KL+IA L+ G+ +E G P + E ++ Sbjct: 1 MKRNVNIVDTTLRDGEQSAGKAFTMEQKLKIAKYLDNNGIYQIECGIPAMGCMEQEIIKA 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKL---RSTLDE 117 I KN+ + R DI + + IH + S + I L + ++E Sbjct: 61 IKANTKNALISTWNRLNIDDIKASMN----CKPHIIHISVPVSDLQIYENLNKDKKWIEE 116 Query: 118 VIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMP 177 + + IY K + Y DV EDA R I + + G I DTVG Sbjct: 117 NLIKCIYYTKE-QGY--DVTVGLEDASRADIKYIIELSSLIEKLGVNRIRYSDTVGILSL 173 Query: 178 FEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 + +++ + R N+ + +H H+D G+A+G S+ AV GA V+ ++GIGER G Sbjct: 174 LKTKNVVNEI-RRNSNLK---VEIHAHNDFGMALGISVEAVKNGAEFVDCTLDGIGERTG 229 Query: 238 NCSLEEVI 245 NCSL+E + Sbjct: 230 NCSLQEFL 237 >UniRef50_Q46A98 Homocitrate synthase n=2 Tax=Methanosarcina RepID=Q46A98_METBF Length = 287 Score = 107 bits (267), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 85/291 (29%), Positives = 136/291 (46%), Gaps = 21/291 (7%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I DTTLRDGEQ+ SV+E++ I AL++ V +E G P + E ++ + Sbjct: 9 IIDTTLRDGEQSAGVVFSVEERMNIISALDKAKVKWIEAGIPAMGKQECEDLKLMLNLPI 68 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFR-IHTFIATSPMHIATKLRSTLDEVIERAIYM 125 S + A R +D+ + + F+ +H + S +HI KL+ + V+++ Sbjct: 69 KSNLIAWNRANLEDLKASIDC-----GFKFVHVSLPVSDLHIEHKLQKSRTWVLDQ---- 119 Query: 126 VKRARNYTDDVEFS----CEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 +K+ Y + + EDA R L + A + GA I DTVG F Sbjct: 120 LKKCMEYLQSCKVTIIVGAEDASRADPEFLLQYAGIAASYGAIRIRYSDTVGCLDHFTTY 179 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 I + + P + +H H+D GLAV N+LAA AGA+ + G+GERAGN S+ Sbjct: 180 RKIKEIADHSP----PPVEIHAHNDFGLAVANTLAAYKAGAKFASVTVTGLGERAGNASM 235 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 EE ++ K N I + + +++VS+ + K +VGS A Sbjct: 236 EETAFSL---KRFYNYDCGIELEALPFLAEMVSKASERTLFPYKPLVGSLA 283 >UniRef50_B0CSN8 Predicted protein (Fragment) n=11 Tax=cellular organisms RepID=B0CSN8_LACBS Length = 603 Score = 107 bits (267), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 91/328 (27%), Positives = 146/328 (44%), Gaps = 31/328 (9%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 I T LRDG QAL ++V++K L + GV +EV +P +S DF+ V+ + + Sbjct: 28 IWLSTDLRDGNQALANPMTVEQKTTFFRQLVKCGVKQIEVAYPAASETDFQFVRGL---I 84 Query: 66 KNSRVC------ALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 +N+ V L E I +S+ A+ +H + ATSP RS+ ++ I Sbjct: 85 ENNEVPDDVWIQVLTPAREDLIRRTIDSVAGAKHAILHMYNATSPTFREVVFRSSKEQTI 144 Query: 120 ERAIYMVKRARNYTDDV----------EFSCEDAGRTP---IADLARVVEAAINAGAT-- 164 + A+ K R T++ E+S E +T ++ V+AA T Sbjct: 145 KLAVEHTKIVRQLTEECTAKYGTVFKYEYSPETFTQTEPEYALEVCEAVKAAWGKAGTGD 204 Query: 165 ---TINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAG 221 N+P TV P +A I + +K IIS+H H+D G A+ ++ + AG Sbjct: 205 DRIIFNLPSTVEIAPPNHYADQIENFCRNISEREKIIISLHPHNDRGTAIASAELGMLAG 264 Query: 222 ARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPI 281 ++EG G GER GN L V +A+ +N ++ +I +V+Q ++P+ Sbjct: 265 GDRIEGCFFGNGERTGNVDL--VNLALNFYSQGIN--PGLDFSDIQSVIDVVTQCNDLPV 320 Query: 282 PANKAIVGSGAFAHSSGIHQDGVLKNRE 309 G F SG HQD + K E Sbjct: 321 HPRHPYAGELVFTAFSGSHQDAIKKGFE 348 >UniRef50_C9K7B8 Similar to 2-isopropylmalate synthase n=1 Tax=Alternaria alternata RepID=C9K7B8_ALTAL Length = 582 Score = 107 bits (266), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 88/323 (27%), Positives = 149/323 (46%), Gaps = 26/323 (8%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESV----QTI 61 ++F T LRDG Q+L ++ ++KL + L +G +EV +P ++ +F+ V +T Sbjct: 62 VLFSTDLRDGNQSLPNPMTFEQKLSLYKLLVSIGFKEIEVAYPCANQAEFDFVRHLIETP 121 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 ++ + + C E+ I A ES++ A+ + T++ +S + T L+ + D+ +ER Sbjct: 122 GLIPEDVLIQVITPCQEETIKRAVESVRGAKQAILFTYLPSSDNYRDTVLKISEDDWVER 181 Query: 122 AIYMVKRARNYTDDVE------------FSCEDAGRTPIADLARVVEAAINAGATT---- 165 A + AR+ T D E F ED I + R EA + Sbjct: 182 ARWGAAYARSITKDSEDPVVRSTRWTFNFGFEDFANARIGAIIRCTEAVRAEWNPSKDEK 241 Query: 166 --INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGAR 223 I + +V + P FA I L + N D ++VHTH+D G AV ++ A AGA Sbjct: 242 MIIGVASSVEASTPNVFADQIECLSGNISNRDTVRLTVHTHNDRGGAVASAELASLAGAD 301 Query: 224 QVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 ++EG + G GERAGN L V+ A+ + + I+ + ++ I +P+ Sbjct: 302 RIEGCLFGNGERAGNMDL--VVYALNLLTQ--GIEPGIDLSRLDEIRKVYEDITELPVHP 357 Query: 284 NKAIVGSGAFAHSSGIHQDGVLK 306 G+ SG HQD + K Sbjct: 358 RTPYSGAYYLKAFSGAHQDAISK 380 >UniRef50_D1N7Y9 Pyruvate carboxyltransferase n=2 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N7Y9_9BACT Length = 567 Score = 105 bits (263), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 118/474 (24%), Positives = 205/474 (43%), Gaps = 47/474 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 ++Q + LRDG QAL + + KL+ L +G +EV FP +S DF V+ Sbjct: 25 LTQPPVWASVDLRDGNQALPEPMGPEHKLEYFNMLVGIGFKEIEVAFPSASADDFNFVRM 84 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + + R+ L + ID ESL+ + H ++ TS +H +E Sbjct: 85 LIERNLIPDDVRISVLTQARRHLIDRTIESLRGVKHAIAHCYVPTSDLHGRFVFNHNREE 144 Query: 118 VIERAI---YMVKRARNYTD-----DVEFSCEDAGRTPIADLARVVEAAINA----GATT 165 V + A+ MVK A EFS E+ + DL VVE G +T Sbjct: 145 VKQMAVDGTRMVKEAIEREGLWGKVAYEFSPEEFTDS---DLDFVVEVCCAVKEVWGPST 201 Query: 166 -----INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHA 220 +N+P TV P ++A +I + P +++ +S+H H+D G AV + A+ A Sbjct: 202 PDMLILNLPATVERRPPNQYADMIELFCRKFPYLNEVGLSLHAHNDQGCAVAATELALLA 261 Query: 221 GARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMP 280 GA +VEG + G GER GN + + + ++ R V T +N + ++V + + Sbjct: 262 GATRVEGTVFGHGERTGNLDVSVLALNMESR----GVRTGLNFSNMPEIVRIVERNSGIE 317 Query: 281 IPANKAIVGSGAFAHSSGIHQDGVLKN-----------RENYEI----MTPESIGLNQIQ 325 + G F SG HQD + K R+ ++I + P +G + Sbjct: 318 VHPRHPYAGDLVFTAFSGSHQDAIRKGFEHRAEISEFFRQGWKIPYLHLDPADLGRQYEK 377 Query: 326 L-NLTSRSGRAAVKHRMD-EMGYKESEYNLDNLYDAFLKLADKK-GQVFDYDLEALAFIG 382 L + S+SG+ V + ++ E G + + K+ D + G++ DL+ + + Sbjct: 378 LIRINSQSGKGGVVYVLEKEFGVYPPKTMHPEIGAVVQKVVDAEGGEINSADLKRIFYDN 437 Query: 383 KQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAI 436 E +R++ + S + + GE+ + + GNGP+ AV A+ Sbjct: 438 FVNAEGP-YRMENYQRASVGDRSGSNFSWFINGEKHEL-SGQGNGPLSAVVHAL 489 >UniRef50_B7GT76 2-isopropylmalate synthase n=19 Tax=Bifidobacterium RepID=B7GT76_BIFLI Length = 638 Score = 104 bits (260), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 146/572 (25%), Positives = 235/572 (41%), Gaps = 104/572 (18%) Query: 12 LRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT-IARQV--KNS 68 LRDG QAL + + KL+ L MG +EVGFP +S DF+ ++ I R++ + Sbjct: 79 LRDGNQALVNPMDSERKLRFWNLLVSMGFKEIEVGFPSASETDFDFIRMLIERELIPDDV 138 Query: 69 RVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKR 128 + L +C E I E+LK A+ +H + + S + R +E+ + A + Sbjct: 139 TIVVLTQCREHLIRRTYEALKGAKRAIVHFYNSVSVLQREVVFRKNKEEIKKLATDAAEL 198 Query: 129 ARNYTDDV-------EFSCEDAGRTPIADLARVVEAAINAGATT------INIPDTVGYT 175 ++ ++ E+S E T V A I T IN+P TV T Sbjct: 199 CKDLENEAKGIDLYYEYSPESFTGTEPEYAVEVCNAVIGVIKPTPEHPMIINLPATVEMT 258 Query: 176 MPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGER 235 P FA + + + + D ++S+H H+D G+ V + AV AGA +VEG + G GER Sbjct: 259 TPNVFADEVEYVSTHLDDRDSVVLSLHPHNDEGMGVAATELAVLAGADRVEGCLLGNGER 318 Query: 236 AGNC-----SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGS 290 GN L + I + D+ NV EI +T + +QI I G+ Sbjct: 319 TGNVDLVTLGLNWLTQGIDPQLDLSNV------PEIRKTVEYCNQI---KISERHPYAGN 369 Query: 291 GAFAHSSGIHQDGVLKNRE--------------------NYEIMTPESIGLN-QIQLNLT 329 F SG HQD + K E Y + P+ IG + + + Sbjct: 370 FVFTAFSGSHQDAIKKGLEARQVAAERAGADLDSFVWLVPYLPIDPKDIGRTYEAIIRVN 429 Query: 330 SRSGRAAVKHRMDEMGYKESEYNLD---NLYDAFLKLADK-----KGQVFDYDLEAL--- 378 S+SG+ + + + ++ +NLD L F K+ K +V D D+ L Sbjct: 430 SQSGKGGMAYLL------KTNHNLDLPKRLQIEFDKIVQNYADTTKKEVKDGDIWRLFKD 483 Query: 379 --------------AFIGKQQE---EPE-HFRLDYFSVQSGSNDIATA--------AVKL 412 +G + EP +L +V SG + T V + Sbjct: 484 EYLPVEQSGMTAAGVVVGDTHDASLEPWGRLKLLKVAVSSGEDGSDTVLKARLLDRGVNV 543 Query: 413 ACGEEVKAEAAN-GNGPVDAVYQAINRITEYNVE--LVKYSLTAKGHGKDALG----QVD 465 E V+ EA+ GNGP+ A +N I+ + VE ++ Y G DA+ + Sbjct: 544 GDDEPVEREASGIGNGPIAAF---LNAISNFGVEASIMDYVEHTMSVGTDAMAASYVECQ 600 Query: 466 IVANYNGRRFHGVGLATDIVESSAKAMVHVLN 497 I + + GVG+ + I S+ KA++ +N Sbjct: 601 IGEADDAQIVWGVGIDSSITTSALKAIISAIN 632 >UniRef50_C7YY11 Putative uncharacterized protein n=2 Tax=Nectriaceae RepID=C7YY11_NECH7 Length = 398 Score = 103 bits (257), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 82/284 (28%), Positives = 141/284 (49%), Gaps = 13/284 (4%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I DTTLR+GEQ A + K++IA AL+ GV+ +E+ P +S Q I + Sbjct: 122 IIDTTLREGEQFATAHFDTETKIKIAQALDEFGVEYLELTSPAASEQSKLDCQAICKLGL 181 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 +++ RC D +A ++ I+ I TS + LD + ++A ++ Sbjct: 182 KAKILCHIRCNMDDARIAVQT----GVDGINMCIGTSAQLMKHSHGKDLDWIAKKATEVI 237 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 + A+++ +V FS ED+ R+ +++ ++ GA + I DTVG E IS Sbjct: 238 QFAQSHGVEVRFSGEDSFRSDFSEIIKLYSLVDRLGAQRVGIADTVGGATWREVDEKIST 297 Query: 187 LYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIM 246 L +V + D I H H+D G AV N+ A+ AGA ++ + GIGER G SL ++ Sbjct: 298 L-RQVISCD---IETHFHNDTGCAVSNAFTALEAGATHIDTTVLGIGERNGITSLGGLMA 353 Query: 247 AIKV--RKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIV 288 ++ K +LN + +++ +LV++ ++ IP N +V Sbjct: 354 SLMYSEHKSVLNKYKL---EKLAALEELVAKAVDVEIPWNNFVV 394 >UniRef50_B8J227 Pyruvate carboxyltransferase n=2 Tax=Desulfovibrio RepID=B8J227_DESDA Length = 611 Score = 102 bits (253), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 110/458 (24%), Positives = 200/458 (43%), Gaps = 41/458 (8%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVD---VMEVGFPVSSPGDFESV 58 ++Q+ I DTT RDG+QA + +VK+ ++ L R+G + F + S D + + Sbjct: 49 AEQMRITDTTFRDGQQA-RPPYTVKQVAKMFDFLHRLGGKTGLITASEFFLYSAKDRKCI 107 Query: 59 QTI-ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 AR + RV A R D+ +A + E + S HI KL T + Sbjct: 108 DVCRARGYRFPRVTAWIRATRDDLKLARD----MEFDETGMLTSVSDYHIFLKLGKTRQQ 163 Query: 118 VIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLA-----RVVEAAINAG-ATTINIPDT 171 ++ + M ++A + ED R I R++E + +G I + DT Sbjct: 164 AMDMYVGMAEQALEWGIIPRCHFEDITRADIYGFCLPLAQRLMELSRQSGMPVKIRLCDT 223 Query: 172 VGYTMPFEFAGI------ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQV 225 +GY +P+ A + I + + + H H+D + N + A G V Sbjct: 224 MGYGVPYPGAALPRSVQRIVRAFTDEAGVPGQWLEWHGHNDFHKVLVNGVTAWLNGCGAV 283 Query: 226 EGAMNGIGERAGNCSLEEVIMA-IKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 + G GER GN LE +++ I + D T + H+ +Q + + IP N Sbjct: 284 NSTLFGFGERTGNTPLEALLVEYISLTGDDAAADTTVLHE----VAQFFEKELDYRIPHN 339 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEM 344 VG A S+G+H DG+ KN E Y I + + + + +T ++GRA V + ++ Sbjct: 340 YPFVGRDFNATSAGVHADGLAKNEEIYNIFDTKHLLGRSVPIIITDKTGRAGVAYWINTN 399 Query: 345 GYKESEYNLD-------NLYDAFLKLADKKGQVFDY---DLEALAFIGKQQEEPEHFRLD 394 E E + +YDA + + ++ G+ ++ ++EAL Q+ PE F + Sbjct: 400 LNLEKERQISKKHPAVGKIYDAIMAVYEETGRTTNFSHVEMEALV----QRFMPELFVSE 455 Query: 395 YFSVQSGSNDI-ATAAVKLACGEEVKAEAANGNGPVDA 431 + +++ + ++ A V+LA +++ + +DA Sbjct: 456 FDNMKQLAGELAANLLVRLARDKDLLDFGEKAHAKIDA 493 >UniRef50_A2QSZ0 Contig An09c0020, complete genome n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2QSZ0_ASPNC Length = 566 Score = 101 bits (252), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 96/384 (25%), Positives = 161/384 (41%), Gaps = 45/384 (11%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFES--- 57 ++Q T LRDG QAL ++ KL+ L ++G +EV +P +S +F+ Sbjct: 29 LTQAPRWLSTDLRDGNQALVQPMNGDLKLRYFQTLIKLGYKEIEVSYPSASQTEFDFTRY 88 Query: 58 -VQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 + T ++ + +A C ++ I E+++ A +H ++TS + T Sbjct: 89 LISTPGIVPDDTWIQVMAPCRDELIQRTIEAVRGARKVVLHIHLSTSDLFREIVYLMTKK 148 Query: 117 EVIERAIYMVKRARNYTDD------------VEFSCEDAGRTPIADLARVVEAAINAGAT 164 E+I+ A+ ++ R T D +EF+ E+ T + + EA A Sbjct: 149 EMIDLAVRCMRMIRELTKDSLDAEMRKTEWTMEFTLENFQDTSVEFALEICEAVKAAWEP 208 Query: 165 T------INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAV 218 T N+P TV +MP FA I + +K +SVH H+D G V + A Sbjct: 209 TTENKIIFNLPSTVEISMPNVFADQIELFCRGISEREKVCVSVHPHNDRGCGVAAAEMAQ 268 Query: 219 HAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICN 278 AGA +VEG + G GER GN L V +A+ + + +N + +V Sbjct: 269 LAGADRVEGCLFGNGERTGNVDL--VTLALNLYTQ--GISPRVNLGNLNEVVAMVEDCTK 324 Query: 279 MPIPANKAIVGSGAFAHSSGIHQDGVLKN------------------RENYEIMTPESIG 320 +PI G F +G HQD + K R Y M P +G Sbjct: 325 IPIHPRAPYAGKYVFCTFTGTHQDAIRKGYNQLQESEKHDATQTPKWRMPYLPMDPADLG 384 Query: 321 L-NQIQLNLTSRSGRAAVKHRMDE 343 ++ + + S+SG++ V ++E Sbjct: 385 RQHEAIVRVNSQSGKSGVAWLLEE 408 >UniRef50_B8DR73 Pyruvate carboxyltransferase n=3 Tax=Desulfovibrio vulgaris RepID=B8DR73_DESVM Length = 455 Score = 100 bits (250), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 107/398 (26%), Positives = 174/398 (43%), Gaps = 30/398 (7%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI-ARQ 64 ++ DTTLR+GEQ+ LS+ ++ ++ L +GV EVG+ + D + + AR Sbjct: 1 MLLDTTLREGEQSFGTYLSMADRERVLRGLAAVGVPEAEVGW--AGREDLTDMLALSARV 58 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 A RC D+ A A R+ + S H+A +L +++ Sbjct: 59 APGLAAAAWCRCRPGDLRAAV----ACGASRVCVGVPVSDAHLARRLGLGRAALLDLLAA 114 Query: 125 MVKRARNY-TDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 + AR + V EDA R A + V A GA + + DTVG P E A + Sbjct: 115 TLAEARMLGIEHVTVGMEDASRADRAFVFAVACHAAAHGAHRVRLSDTVGLYTPLEVADV 174 Query: 184 ISGLY---------ERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 + L + P + I H H+D G+A N+L A+ GA + ++ G+GE Sbjct: 175 VRALRAELEGARQDDTAPRARRVSIGTHFHNDCGMATANALTALECGADCADVSVLGLGE 234 Query: 235 RAGNCSLEEVIMAIKVRKDI---LNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSG 291 RAG LEE+ A+ VR L A+ Q V+Q ++ +P + + G Sbjct: 235 RAGVARLEELAAALVVRGRARFELAPLRALCGQ--------VAQAASLSVPRHWPVAGRD 286 Query: 292 AFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEY 351 FA SG+H GV ++ +E PE +G + ++ + +SG AAV + E+ Sbjct: 287 IFAVESGLHAHGVRRDPSLFEPFPPELVG-DSRRMGVGRKSGVAAVAAALAELSILPPPD 345 Query: 352 NLDNLYDAFLKL-ADKKGQVFDYDLEALAFIGKQQEEP 388 L + +A L A + + +L +A +GK P Sbjct: 346 ELPAIVEAVRDLSATLRRPLTPAELAEVAGLGKHHAPP 383 >UniRef50_Q1QBL0 2-isopropylmalate synthase n=5 Tax=Bacteria RepID=Q1QBL0_PSYCK Length = 594 Score = 99.8 bits (247), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 110/472 (23%), Positives = 204/472 (43%), Gaps = 39/472 (8%) Query: 12 LRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ---VKNS 68 LRDG QAL +++++K++ L +G +E+GFP ++ +F+ + + + + Sbjct: 58 LRDGNQALIDPMTIEQKMRFFETLIDVGFKEIEIGFPSAAQVEFDFARKLIEENHVPDDV 117 Query: 69 RVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMH---IATKLRSTLDEV-IERAIY 124 + L + E I ESLK A+ +H + +T + + K ++ + E+ + A Sbjct: 118 TLQVLVQAREHLIARTFESLKGAKRAIVHVYNSTCRIQREKVYAKDKAEIKEIAVTGAKL 177 Query: 125 MVKRARNYTDD---VEFSCEDAGRTPIADLARVVEAAI------NAGATTINIPDTVGYT 175 +V+ A Y + ++S E +T V +A N +N+P TV + Sbjct: 178 LVEYAAKYPETEWVFQYSPESFSQTETEYAVEVCDAVCDVWRPENGQEVILNLPATVEAS 237 Query: 176 MPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGER 235 MP FA + + + IS+HTH+D G AV + V AGA ++EG + G GER Sbjct: 238 MPNVFADQVEYFCRNLAKREHVTISLHTHNDRGCAVAAAELGVLAGADRIEGTLLGNGER 297 Query: 236 AGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAH 295 GN + ++MA+ + + ++ + Q+VS+ N+P+ VG F Sbjct: 298 TGNMDI--MVMAMNLFSQ--GIDPELDFSNMSEIVQVVSECNNLPLHPRHPYVGELVFTA 353 Query: 296 SSGIHQDGVLK----------NREN-----YEIMTPESIGLN-QIQLNLTSRSGRAAVKH 339 SG HQD + K EN Y + P IG + Q + + S+SG+ V + Sbjct: 354 FSGSHQDAIKKCLDYNEKHVEKTENVWDVAYLPIDPAHIGRSYQDVVRINSQSGKGGVAY 413 Query: 340 RMDE-MGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSV 398 + G+ + + K A+ + D F ++ LDY Sbjct: 414 ILQRNYGFNLPRWMQIDFSGVVQKQAETTARELQNDEILQTFEDTYLQQGSFELLDYTVN 473 Query: 399 QSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYS 450 G V++ G+ + + +GNGP+ + + + T ++ ++ Y+ Sbjct: 474 NKGGEVYFNGQVQMN-GDTITID-GDGNGPLSSFIDGLAQHTGKSIHVINYA 523 >UniRef50_C1FHL1 2-isopropylmalate synthase n=2 Tax=cellular organisms RepID=C1FHL1_9CHLO Length = 662 Score = 99.4 bits (246), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 98/360 (27%), Positives = 159/360 (44%), Gaps = 41/360 (11%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V+ +DTTLRDG Q + SL+ +KL +A L +GV +E G+P S+P D E Sbjct: 64 VVCYDTTLRDGSQQVGISLTCDDKLAVAEHLVGLGVAYIEGGYPGSNPKDVEFFSRWTSS 123 Query: 65 VKNSRVCA----LA-------RCVEKDIDVAAESLK---------VAEAF--RIHTFIAT 102 R A LA R V D D ++L VA+A+ + + Sbjct: 124 GLADRAAAGGTKLAAFGMTRRRGVTADDDEGLKALTDCPAPCVCIVAKAWDEQCEKVLGV 183 Query: 103 SPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAG 162 SP + ++ ++ ++ +Y D GR + A AA Sbjct: 184 SPEENIAMIEESVAHLVAAGKEVLVDCEHYFD---------GRKANPEFAVKCAAAAAKS 234 Query: 163 ATT-INIPDTVGYTMPFEFAGIISGLYERVPNID-KAIISVHTHDDLGLAVGNSLAAVHA 220 + + DT G T+P++ + E V + +H H+D LAV NS+AAV Sbjct: 235 GAKFVVLCDTNGGTLPWDVEEFTREVKEAVDATGADCSVGIHCHNDTSLAVANSIAAVRG 294 Query: 221 GARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQL---VSQIC 277 GA V+G +NG GER GN L V ++++ TA+ + R +Q+ V+++C Sbjct: 295 GATMVQGCVNGYGERTGNADLLVVAANLELKMG----RTALPEGSLQRLTQVSAAVAKLC 350 Query: 278 NMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAV 337 + + +GS AFAH G+H + K +Y + P +G N+ + ++ SGR + Sbjct: 351 SQHQDPRQPYMGSSAFAHKGGLHVAALQKMPASYNHIVPTLVG-NEARSVISELSGRGNI 409 >UniRef50_B1L5J0 2-isopropylmalate synthase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5J0_KORCO Length = 426 Score = 98.2 bits (243), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 97/362 (26%), Positives = 154/362 (42%), Gaps = 40/362 (11%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERM----GVDVMEVGFPVSSPGDFES 57 S ++I DTTLRDG+Q S +E ++I L + GV FP +S D E Sbjct: 22 SHDLLITDTTLRDGQQG-SRPFSKEECIKIYSILSELDGGSGVIRDIELFPYTS-KDREV 79 Query: 58 VQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 ++ + R +D+ + E + S HI KLR + E Sbjct: 80 IKALRDFGTTPNPIGWIRARIEDLKLVKECGLDTTVL----LTSVSDYHIHYKLRMSRTE 135 Query: 118 VIERAIYMVKRARNYTDDVEFSCEDAGRTPI--------ADLARVVEAAINAGATTINIP 169 E+ + ++ ++ + ED R+ I D+ R+ E G + I Sbjct: 136 AREKFLSAIREGLRMGLKLKVAMEDITRSDIYGFVLPFIEDILRISER--EGGEVSFKIS 193 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIIS----------VHTHDDLGLAVGNSLAAVH 219 DT+G +PF + + G VP + +++I H H+D L V N LAA Sbjct: 194 DTLGLALPFPESPLPRG----VPRLIRSLIEEMGLRSEQIEFHGHNDFHLVVANHLAAWL 249 Query: 220 AGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNM 279 GA + GIGERAGNC LE A+ + L+ +N + + + + S++ Sbjct: 250 YGASISNCTLMGIGERAGNCPLE----AMAIMHSQLSGERKLNLKALSKIIDVFSEM-GF 304 Query: 280 PIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKH 339 IP I+G AF +GIH DG+LKN Y P IG + ++ SGR+ + + Sbjct: 305 RIPEFYPILGENAFKTKAGIHIDGLLKNPAIYLPFDPTIIG-RPYSIEISPYSGRSGIIY 363 Query: 340 RM 341 + Sbjct: 364 WL 365 >UniRef50_D2JWV4 Putative homocitrate synthase n=1 Tax=Filobasidiella depauperata RepID=D2JWV4_9TREE Length = 465 Score = 94.7 bits (234), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 92/384 (23%), Positives = 164/384 (42%), Gaps = 61/384 (15%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR-QV 65 I ++TLR+GEQ A +++ K++IA L+ GV+ +E+ P +SP + I + + Sbjct: 69 IIESTLREGEQFANAFFNLETKIKIAKMLDEFGVEYIELTSPAASPESRAHCEAICKLGL 128 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 K +++ RC D +A E+ +D VI + ++ Sbjct: 129 KKTKILTHIRCHMDDARLAVETGV-----------------------DGVDVVIGTSSFL 165 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINA-GATTINIPDTVGYTMPFEFAGII 184 + + D+A + + ++ G + + DTVG P + ++ Sbjct: 166 REHSHG-----------------KDMAWITKTTVDKIGVNRVGVADTVGCADPRQVYDLV 208 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLA-----------VGNSLAAVHAGARQVEGAMNGIG 233 L V I H H+D G + N+ AA+ AGA V+ ++ GIG Sbjct: 209 RTLRGVV----SCDIETHFHNDTGCGKASTLDESTAPIANAYAALEAGATHVDTSILGIG 264 Query: 234 ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAF 293 ER G L +I + V D V + N + V++ + +P N I G AF Sbjct: 265 ERNGITPLGGLIARMMV-ADPDYVKSKYNLTMLRELENTVAEAVEVQVPFNNYITGFCAF 323 Query: 294 AHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSR-SGRAAVKHRMDEMGYKESEYN 352 H +GIH +L N YEI+ P G+ + +++ R +G AVK R++++ ++ Sbjct: 324 THKAGIHAKAILANPSTYEILNPADFGMTRY-VSIGHRLTGWNAVKSRVEQLNLNLTDEQ 382 Query: 353 LDNLYDAFLKLADKKGQVF-DYDL 375 + + +LAD + Q D D+ Sbjct: 383 VKDATAKIKELADVRTQSMEDVDM 406 >UniRef50_D0LGL9 2-isopropylmalate synthase n=3 Tax=Nannocystineae RepID=D0LGL9_HALO1 Length = 424 Score = 94.7 bits (234), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 83/314 (26%), Positives = 152/314 (48%), Gaps = 17/314 (5%) Query: 3 QQVIIFDTTLRDGEQALQA-SLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 +QV TLRDG Q+ + +KL++ + +G+ +++G P + E TI Sbjct: 29 RQVSFLCETLRDGIQSPSVVDPDIGDKLRLVELADSLGIHHIDIGLPGAGNRAVEDCTTI 88 Query: 62 ARQVKNSRV-----CALARCVEKDIDVAAE-SLKVAEAFRIHTFIATSPMHIATKLRSTL 115 A ++++++ CA AR + D+ + S V + TFI +SP+ + L Sbjct: 89 ATFIRDNKLRIRPACA-ARTHKNDVGAIVDISQAVGIEIEVLTFIGSSPIRQYAE-SWDL 146 Query: 116 DEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYT 175 + ++ + + A + V F ED R+ L ++ AI GA + + DTVG++ Sbjct: 147 ERMLNFSSEAIDLAARHNLPVTFVTEDTTRSRPEVLDQMFRNAIEHGANRLCLCDTVGHS 206 Query: 176 MPFEFAGIIS---GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 P +I L E + D I H H+D GL V N++ A+ GA +V G G+ Sbjct: 207 TPDGIHNLIRFTRNLLEAMGRPDVGI-DWHGHNDRGLGVVNTIFAIEYGASRVHGTAMGL 265 Query: 233 GERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 GER GN +L++V++ +K+ ++ +W ++ ++ C++ IP + GS A Sbjct: 266 GERVGNAALDQVLLNLKLLG--ELPEQDLSKLLLW--CKVAAKACHVAIPPQYPLAGSDA 321 Query: 293 FAHSSGIHQDGVLK 306 F ++G+H ++K Sbjct: 322 FRTATGVHAAAIIK 335 >UniRef50_B2J8P8 Pyruvate carboxyltransferase n=2 Tax=Nostocaceae RepID=B2J8P8_NOSP7 Length = 392 Score = 93.2 bits (230), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 87/337 (25%), Positives = 147/337 (43%), Gaps = 35/337 (10%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 +II D TLRDGEQ S K ++A + + GVD + + P + E V+++ + Sbjct: 6 IIISDETLRDGEQQAGIFFSYPTKQKLAHLIAQTGVDRLSM-MPRVHEQEEELVKSLVSE 64 Query: 65 VKNSRVCALARCVEKDIDVAA----------------------ESLKVAEAFRIHTFIAT 102 +S + A ++ ID A +++ F+ T Sbjct: 65 GLDSLIAAATMTGKQYIDQAKMYGVKRIILFYGLSDRLLFLRDPQIRLLNEFKGKTIDDD 124 Query: 103 SPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAG 162 P + ++R ++I ++ T V+F+ EDA R L + + + + Sbjct: 125 IPKKVIERIRQNAIDLIVENLHYATTVAGLT--VDFAAEDASRADFDFLVQCIRS-FSPY 181 Query: 163 ATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGA 222 + DTVG P + I+ L +R + VH H+D+GLA+ N+L +V AGA Sbjct: 182 LDHFMLCDTVGVLTPEKSYIWINDLLQRTTGV---AFGVHYHNDMGLALENTLQSVIAGA 238 Query: 223 RQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIP 282 V G GIGERAGN ++E+V+ ++VR I IN+ I + + Q+ P P Sbjct: 239 TLVSGTFCGIGERAGNVAIEQVLNGLRVRFGI--EVKGINYDAIAAVTDYIEQLGIRPAP 296 Query: 283 ANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESI 319 A H SGIH + + + ++Y + +I Sbjct: 297 P----YSQTAQRHESGIHVNSLFSDPQSYAALPYNTI 329 >UniRef50_C8QZK2 2-isopropylmalate synthase n=1 Tax=Desulfurivibrio alkaliphilus AHT2 RepID=C8QZK2_9DELT Length = 399 Score = 92.4 bits (228), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 93/339 (27%), Positives = 160/339 (47%), Gaps = 30/339 (8%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVS------SPGDFES- 57 V + D+TLR+G Q + LS+ ++ +A +G++ +EVG PV PGD+ + Sbjct: 2 VGLIDSTLREGLQGVGVELSLDRQVAVAAGSVALGLEELEVG-PVGLAAATMEPGDYLAR 60 Query: 58 -VQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 + + + R+ RC+ DI+ SL + + I S + +KL T Sbjct: 61 LIPRLRHEAGVRRLALWCRCLPDDIE---RSLALNPDV-LALSIPASHRQMTSKLGKTAA 116 Query: 117 EVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTM 176 EV A ++ AR + ED R + ++ A++ G + + DTVG + Sbjct: 117 EVRTLAAAALELARGRVPYLALGLEDVTRAEPNFVRQMAVLAVDHGVDRLRLADTVGISA 176 Query: 177 PFEFAGIISGLYERVPNI------DKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMN 230 P E A ++ + E + ++ I VHTH+D GLA N++AA+ AGA + ++ Sbjct: 177 PDEIADLVGRVREYLREAGGDGRGNQVAIGVHTHNDFGLAGANAIAALAAGADWADVSLL 236 Query: 231 GIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQI---CNMPIPANKAI 287 G+GERAG LEEV + +R+ +H + R +L Q+ C IP+ + + Sbjct: 237 GLGERAGLARLEEVATYLALRRG--------HHYRLERLPELAQQLAGFCGREIPSWRPV 288 Query: 288 VGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQL 326 VG F+ +G+H + + +YE PE +G + L Sbjct: 289 VGRDVFSCETGLHLAAIQLDPASYEPFAPELVGQRRTLL 327 >UniRef50_A8MB07 2-isopropylmalate synthase n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8MB07_CALMQ Length = 355 Score = 92.0 bits (227), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 89/376 (23%), Positives = 162/376 (43%), Gaps = 44/376 (11%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 +I D TLR+G QA S +V+EK+++A + GVD V P + + E + I + Sbjct: 1 MIIDDTLREGLQAPGISFTVEEKIELAKLISNAGVDEAIVSHPSAHESEVEVTRIIVERN 60 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 V L R +++DID+ A + I T+I P + L +VI+ A+ Sbjct: 61 YFKYVFGLGRALKEDIDLIAST-----GANISTYIPFEPQLVNKSL-----DVIKYAVNT 110 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 + + +E + ++++ ++ + G I + D++G P I++ Sbjct: 111 YGKGKLI---IEVGITNITAYELSNIVKLAKTLEELGVDRIQLADSLGKATPKLMYNIVN 167 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245 + V K +SVH H+D+G AV NS+++V+AGA V+ + GIGER G L + Sbjct: 168 NVKHTV----KIPVSVHCHNDMGAAVANSISSVYAGADYVDATIYGIGERNGIADLATIA 223 Query: 246 MAI-----KVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 M + ++ D + A N + ++ +I N + G+ ++G H Sbjct: 224 MILRNDSYRINIDFEKLRDAYN----YLAKLIIDKIDIEFFRNNFPVFGNNISIQTAGTH 279 Query: 301 --QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYD 358 GV K ++ +L GR+ ++ + E+G ++ L L Sbjct: 280 AAYPGVFK----------------EVGYSLNVYVGRSTLRKVLSELGISLNDQELLMLMR 323 Query: 359 AFLKLADKKGQVFDYD 374 A + G+ YD Sbjct: 324 KIKDTAVRTGRAVTYD 339 >UniRef50_B4VB43 2-isopropylmalate synthase n=1 Tax=Streptomyces sp. Mg1 RepID=B4VB43_9ACTO Length = 474 Score = 92.0 bits (227), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 79/310 (25%), Positives = 154/310 (49%), Gaps = 18/310 (5%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERM-GVD-----VMEVGFPVSSPGDFES 57 +V++++ + RDG QA + ++ ++++A R+ G D V+ GFP +FE+ Sbjct: 53 RVVLWEESARDGAQA-KTLMTAGFRVRLARETGRIFGSDGPRHVVIAAGFPAVCGEEFEA 111 Query: 58 VQTIARQVKNS-RVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 V+ +A + + + V A+ R +D++ A S++ + R+ + S + Sbjct: 112 VRRVAGEAEGAVSVAAVCRGARRDLEQAVASVRGSRQARVMVVVPASEAMARVMVHRAAR 171 Query: 117 EVIERAIYMVKRARNYTDDV--EFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGY 174 E ++ + +VKRAR+ + V + DA R A +A A AGA + + DTVG Sbjct: 172 EALQAGVDLVKRARDLDEGVAVDVCLADASRADHALMAHYARAMTGAGAGLVVLADTVGA 231 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 +P A + + R + +++ H H+DLGL + N+L A+ AG R + GI E Sbjct: 232 QLPSGCAEMFRRV--RAEAGSEVVLASHLHNDLGLGLANTLEALAAGVRVASSSWLGIAE 289 Query: 235 RAGNCSLEEVIMAI-KVRKDILNVHTA--INHQEIWR---TSQLVSQICNMPIPANKAIV 288 RAG + E+++ + + +++L A + ++ R +++V+ +P+ IV Sbjct: 290 RAGMVATEQLLFLLARHARELLGAGAAPWWSPPDLTRLPVIAEMVAGETGVPLGVTTPIV 349 Query: 289 GSGAFAHSSG 298 G+G + S+G Sbjct: 350 GTGVGSLSTG 359 >UniRef50_Q0PQP4 2-isopropylmalate synthase (Fragment) n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2' RepID=Q0PQP4_9GAMM Length = 142 Score = 91.3 bits (225), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 41/68 (60%), Positives = 58/68 (85%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 ++IIFDTTLRDGEQ+ AS++ +EK++IA ALE++ VDV+E GFP++S GDFE+VQ +AR Sbjct: 6 RLIIFDTTLRDGEQSPGASMTKEEKVRIAKALEKLRVDVIEAGFPIASQGDFEAVQAVAR 65 Query: 64 QVKNSRVC 71 +K+S VC Sbjct: 66 AIKDSTVC 73 >UniRef50_D2MHM3 2-isopropylmalate synthase (Fragment) n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MHM3_9BACT Length = 157 Score = 91.3 bits (225), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 55/158 (34%), Positives = 87/158 (55%), Gaps = 7/158 (4%) Query: 360 FLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVK 419 F +LAD+K ++F+ DLE++ + PE + L + QSG+N + TA V+L V Sbjct: 2 FKRLADQKKELFEEDLESIVSEAVTKV-PERYSLQSLNTQSGTNQLPTATVELEMDGHVI 60 Query: 420 AEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVG 479 E G+GPVDAVY+ I IT+ +L+ Y + A G DA G+V + +G G G Sbjct: 61 KETGTGDGPVDAVYRTIAGITQTKSKLLAYVVKAITGGTDAQGEVSVRVEQDGEIVTGNG 120 Query: 480 LATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNE 517 TDI+ +SA+A ++ LN + +L+R+A + Sbjct: 121 ANTDIIVASAQAYLNALNKLA------SQLERRANQGD 152 >UniRef50_C1MYB9 2-isopropylmalate synthase n=1 Tax=Micromonas pusilla CCMP1545 RepID=C1MYB9_9CHLO Length = 757 Score = 90.9 bits (224), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 96/344 (27%), Positives = 153/344 (44%), Gaps = 42/344 (12%) Query: 22 SLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFE-------SVQTIARQVKNSRVCALA 74 SL+ +KL++A L +GV +E G+P S+P D E S A + + +++CA Sbjct: 152 SLTCDDKLEVASHLVSLGVSHIEGGYPGSNPKDVEFFNRWDSSGLAKAAEARGTKLCAFG 211 Query: 75 RCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI----------- 123 K ++ K E I K DE ER + Sbjct: 212 MTRRKGVEA-----KDDEGLNALVRCVAPCACIVAK---AWDEQCERVLGVSGEENLAMI 263 Query: 124 -----YMVKRARNYTDDVEFSCEDAGRTPIADLA-RVVEAAINAGATTINIPDTVGYTMP 177 Y+V+R + D E + G + A R AA AGAT + + DT G T+P Sbjct: 264 TDSVSYLVERGKEVLVDCEHFYD--GHAANGEFAMRCAVAAAEAGATHVVLCDTNGGTLP 321 Query: 178 F----EFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIG 233 + + ++ L + + + VHTH+D LAV NSLA V GA V+G +NG G Sbjct: 322 WVVEEKTRAVVDALKKS--SNPSCRVGVHTHNDTALAVANSLAGVRGGASMVQGCVNGYG 379 Query: 234 ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAF 293 ER GN + V ++++ + + ++ T+ V++ C P+ A + VGS AF Sbjct: 380 ERTGNADVLVVAANLELKMGVTALPPG-GVAKLTATAAAVAKACKQPLEARQPYVGSSAF 438 Query: 294 AHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAV 337 AH G+H + K +Y + P ++G N + ++ SGR V Sbjct: 439 AHKGGLHVAALAKMPSSYNHVVPGTVG-NAARSVVSELSGRGNV 481 >UniRef50_Q5KCL7 2-isopropylmalate synthase, putative n=1 Tax=Filobasidiella neoformans RepID=Q5KCL7_CRYNE Length = 639 Score = 90.9 bits (224), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 134/608 (22%), Positives = 231/608 (37%), Gaps = 128/608 (21%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 I T LRDG Q+L ++ ++KL+ L ++G +EV +P +S D+ V+ + + Sbjct: 34 IWLSTDLRDGNQSLANPMTNQQKLRFFRHLVQLGFKEIEVAYPAASETDYNFVRELIDRK 93 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFR---IHTFIATSPMHIATKLRSTLDEVIERA 122 + + D+ + + + +H + ATS + + DE I+ A Sbjct: 94 EVPDDVWIQVLTPARADLIKRTFEAVAGLKHVIVHMYNATSCLFREVVFNNDRDETIKLA 153 Query: 123 ----IYMVKRARNYTDD------VEFSCEDAGRT--PIA-DLARVVEAAINAGATTI--- 166 I + + A Y + E+S E +T P A ++ V+ A G ++ Sbjct: 154 MDHTILIRQLAEKYAESHGTSFRYEYSPETFSQTETPYAVEVCEAVKKAWLGGHGSVWAD 213 Query: 167 ---------NIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAA 217 N+P TV P FA + + +K IIS+HTH+D G AV + Sbjct: 214 GRKEERIIFNLPATVEVATPNCFADQVEIFCNSISEREKCIISLHTHNDRGCAVAAAELG 273 Query: 218 VHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQIC 277 V AGA ++EG + G GER GN L V +A+ + ++ +++ V++ Sbjct: 274 VLAGADRIEGTVLGNGERTGNVDL--VTLALNCYSQ--GISPNLDFSDMFSVIDTVTECT 329 Query: 278 NMPIPANKAIVGSGAFAHSSGIHQDGVLKNRE---------------NYEIMTPESIGLN 322 +P+ G F SG HQD + K E Y + P +G Sbjct: 330 GLPVHPRHPYAGELVFTAFSGSHQDAIKKGFEAQAKRDHAGDQVWSMPYLPIDPADVGCT 389 Query: 323 -QIQLNLTSRSGRAAVKH------------RMDEMGYK---------ESEYNLDNLYDAF 360 + + + S+SG+ + + RM YK E ++ AF Sbjct: 390 YEAVIRVNSQSGKGGIAYIVKSALSLDLPRRMQIAFYKVVQECSEATGREMTSKDITTAF 449 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQS----GSNDIA-------TAA 409 + G ++D L +F+ +D FS Q+ G+ D++ T Sbjct: 450 RQTYHLGGSIYDGRLVLKSFV----------TVDLFSSQTPSVAGTPDLSPIRSRSQTRM 499 Query: 410 VKLACGEEVKAEAAN------------------------------GNGPVDAVYQAINRI 439 L+ V + + GNGP+ + A+ Sbjct: 500 PPLSLSSSVAEPSPDRSLDRNLPSMSKRLTAKVLVDGKLHEIVGEGNGPLSSFLNALESD 559 Query: 440 TEYNVELVKYSLTAKGHGKD--ALGQVDIV-ANYNGRR-----FHGVGLATDIVESSAKA 491 + + +Y+ A G G D A V+++ AN + + F GVG+ DI S KA Sbjct: 560 LGIVLSVREYTEHAVGAGSDVKAATYVELIPANVDAKDKTQGGFWGVGVDADITASGLKA 619 Query: 492 MVHVLNNI 499 +V N Sbjct: 620 VVSAANGF 627 >UniRef50_Q72WS3 Homocitrate synthase n=2 Tax=Desulfovibrio vulgaris RepID=Q72WS3_DESVH Length = 384 Score = 90.1 bits (222), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 100/346 (28%), Positives = 158/346 (45%), Gaps = 32/346 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + + V++ D+TLR+G QA ++ I + GV E G+ + D + Sbjct: 18 LRRCVMLIDSTLREGAQAYGVYFDAADRESILQGVAASGVTEAEAGW--AGQDDLAATLR 75 Query: 61 IARQVKNS-RVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + +V S R+ RC D+D AAE A A R+H + +S H+ +L DEV+ Sbjct: 76 LGARVAPSLRLAVWCRCCTADLDKAAE----AGARRVHIGVPSSDAHMRLRLGMGRDEVL 131 Query: 120 ERAIYMVKRARNYTD-DVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 +R +++ A + V EDAGR L + A GA + DTVG P Sbjct: 132 QRVTTVLEHAAHLGFLHVTLGLEDAGRAAPDLLEALARTAARTGAHRLRCSDTVGLLTPD 191 Query: 179 EFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGN 238 ++ L R + ++VH H+DLGLA N+LAA+ AGA + ++ G+GERAG Sbjct: 192 GMVRLVL-LARRASALP---VAVHCHNDLGLATANALAALDAGADGADVSLLGLGERAGI 247 Query: 239 CSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICN-------MPIPANKAIVGSG 291 EE+ A+ V + E +R L +C M +P + A+ G Sbjct: 248 TRAEELAAALVVLRG-----------ESYRLDML-RGVCRRLAASLEMRLPPHWAVAGEN 295 Query: 292 AFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAV 337 FA SG+H GV ++ +E P +G + +L + + G A V Sbjct: 296 LFAVESGVHLHGVQRDPALFEPFPPALVGAER-RLGVGGKCGSAGV 340 >UniRef50_B5HTY3 2-isopropylmalate synthase n=1 Tax=Streptomyces sviceus ATCC 29083 RepID=B5HTY3_9ACTO Length = 593 Score = 89.4 bits (220), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 88/311 (28%), Positives = 139/311 (44%), Gaps = 21/311 (6%) Query: 12 LRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQ---TIARQVKNS 68 LRDG QAL + ++ K ++ L R+G +E+G+P +S +FE V+ T + Sbjct: 79 LRDGNQALANPMDLRRKRKMFDLLVRLGFKDIEIGYPSASETEFEFVRHLITGGHIPDDV 138 Query: 69 RVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI-------ER 121 V + + ID E+++ + +H AT+ + R T EV+ +R Sbjct: 139 TVTVFTPAIPELIDRTFEAVRGTDRAVVHLCHATACLWREVVFRKTPSEVMALAQESAQR 198 Query: 122 AIYMVKRARN-----YTDDVEFSCEDAGRTPIAD-LARVVEAAINAGATTINIPDTVGYT 175 + + RA Y+ + E IA+ +A +VEA T+N+P TV Sbjct: 199 LVRLADRADGAIRFEYSPETFNVTEPQFALEIANTVAEIVEATPER-PLTLNLPSTVEMH 257 Query: 176 MPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGER 235 P FA I + + D I+SVH H+D G AV + A+ AGA +VEG + G GER Sbjct: 258 APTVFADQIEWMSRNLDRRDGIILSVHPHNDRGTAVAAAEFALAAGADRVEGTLFGNGER 317 Query: 236 AGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAH 295 GN L + + + R V ++ +I + + MP+P G F Sbjct: 318 TGNVCLITLALNLFSR----GVDPQLDLSDIPSVRRAAEECNRMPVPDRHPYAGDLVFTA 373 Query: 296 SSGIHQDGVLK 306 SG HQD + K Sbjct: 374 FSGTHQDAIAK 384 >UniRef50_C7GH85 2-isopropylmalate synthase n=3 Tax=Roseburia RepID=C7GH85_9FIRM Length = 443 Score = 89.0 bits (219), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 91/367 (24%), Positives = 152/367 (41%), Gaps = 27/367 (7%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVD---VMEVGFPVSSPGDFES 57 M + + I DTT RDG+Q+ +A + ++ + I L R+G + + F + S D ++ Sbjct: 86 MPENIWITDTTFRDGQQS-RAPYTTEQIVTIYDYLHRLGGPKGLIRQSEFFLYSKKDRDA 144 Query: 58 V-QTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 V + + R K V + R ++D + + + + E ++ S HI K++ T Sbjct: 145 VYKCLERGYKFPEVTSWIRASKQDFQLVKD-IGLRET---GILVSCSDYHIFYKMKMTRR 200 Query: 117 EVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIP------D 170 EV+ + +++ ED R+ I + IP D Sbjct: 201 EVMNLYLSVIRECLETGISPRCHLEDITRSDIYGFVIPFCVELMKLMDEYKIPIKIRACD 260 Query: 171 TVGY-------TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGAR 223 T+GY +P GII GL + +I H H+D AV NS A GA Sbjct: 261 TMGYGVNFPGAVIPRSVPGIIYGLTTHA-GVPSELIEWHGHNDFYKAVNNSTTAWLYGAS 319 Query: 224 QVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 V ++ GIGER GN LE ++ K L+ ++ I ++ + P+ Sbjct: 320 GVNCSLFGIGERTGNTPLEAMVFEYAQLKGTLD---GMDTTVITELAEYFEKELGYVQPS 376 Query: 284 NKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDE 343 VGS +GIH DG+LKN E Y I Q +++ + R+ +D+ Sbjct: 377 RTPFVGSNFNVTRAGIHADGLLKNEEIYNIFDTGKF-FKQTTISICFQHIRSCRNRSLDQ 435 Query: 344 MGYKESE 350 + SE Sbjct: 436 LLLPSSE 442 >UniRef50_A5N6T4 2-isopropylmalate synthase-related protein n=2 Tax=Clostridium kluyveri RepID=A5N6T4_CLOK5 Length = 453 Score = 88.6 bits (218), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 89/358 (24%), Positives = 154/358 (43%), Gaps = 34/358 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVD---VMEVGFPVSSPGDFES 57 + + I DTT RDG+Q++ S +E ++I L + + + + F + + D ++ Sbjct: 42 LPDNIYITDTTFRDGQQSMPPYTS-REIVRIFDYLHELDNNSGIIKQTEFFLYTKKDRKA 100 Query: 58 VQT-IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 + + R + V + R ++D+ + + + + E ++ S HI KL+ T Sbjct: 101 AEVCMERGYEFPEVTSWIRADKEDLKLVKD-MGIKET---GMLMSCSDYHIFKKLKMTRK 156 Query: 117 EVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAIN---AGATTINIP---- 169 E ++ + + + A N ED R AD V +N + NIP Sbjct: 157 ETMDMYLDLAREALNNGIRPRCHLEDITR---ADFYGFVVPFVNELMKMSKEANIPIKIR 213 Query: 170 --DTVGYTMPF-------EFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHA 220 DT+G +P+ GII GL + + I H H+D V NS A Sbjct: 214 ACDTLGLGVPYNGVEIPRSVQGIIHGL-RNICEVPSESIEWHGHNDFYGVVTNSSTAWLY 272 Query: 221 GARQVEGAMNGIGERAGNCSLEEVIMAI-KVRKDILNVHTAINHQEIWRTSQLVSQICNM 279 GA + + GIGER GNC LE +I +++ + N+ + I +Q + Sbjct: 273 GASSINTSFLGIGERTGNCPLEAMIFEYAQIKGNTKNMKLHV----ITELAQYFEKEIKY 328 Query: 280 PIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAV 337 +P VG+ +GIH DG+LK+ E Y I + I + + ++ SGRA + Sbjct: 329 SVPVRTPFVGTDFNVTRAGIHADGILKDEEIYNIFDTDKILGRPVVVAVSQYSGRAGI 386 >UniRef50_D1XS06 2-isopropylmalate synthase n=1 Tax=Streptomyces sp. ACTE RepID=D1XS06_9ACTO Length = 612 Score = 88.2 bits (217), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 133/550 (24%), Positives = 219/550 (39%), Gaps = 71/550 (12%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +++ + LRDG QAL + K ++ L MG +EVG+P +S DF V+ Sbjct: 74 LTRAPLWVPVDLRDGNQALAEPMDAARKRRMFDLLVAMGFKEIEVGYPSASETDFGFVRH 133 Query: 61 IARQ--VKNSRVCALARCVEKD-IDVAAESLKVAEAFRIHTFIATSPMH---IATKLRST 114 +A V + ++ D ID S++ +H + AT+P+ + + R+ Sbjct: 134 LAESGAVPDDVTVSVFTAARSDLIDRTIASVEGLPRTLVHLYTATAPVWRDVVLGRSRAE 193 Query: 115 LDEVI-ERAIYMVKRA--RNYTD-DVEFSCEDAGRT-P-----IAD-LARVVEAAINAGA 163 L +I + A ++++RA R D EFS E T P + D L + EA+ + Sbjct: 194 LHAMITDAATHLLRRAGERPGADIRFEFSPEVFNLTEPDFVLEVCDSLTELWEASPDR-P 252 Query: 164 TTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGAR 223 N+P TV P +A I ++ + D I+SVH H+D G V + AV AGA+ Sbjct: 253 VVHNLPATVEIATPNVYADQIEYMHRHLARRDSVILSVHPHNDRGTGVACAELAVLAGAQ 312 Query: 224 QVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 +VEG + G GER GN L V +A+ + V ++ +I ++V +P+ Sbjct: 313 RVEGCLFGNGERTGNVDL--VTLALNLFAQ--GVDPMVDFSDIDAVREVVEHCNRLPVHP 368 Query: 284 NKAIVGSGAFAHSSGIHQDGVLKNREN--------------------YEIMTPESIGLNQ 323 G SG HQD + K Y + P IG Sbjct: 369 RHPYGGELVHTAFSGTHQDAIAKGMARHAKRAAEQGVPAAEAPWEVPYLPVDPGDIGRTY 428 Query: 324 IQ-LNLTSRSGRAAVKHRMD-EMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFI 381 + + + S+SG+ V H + G + + ++ D G+ +L A Sbjct: 429 EEVIRINSQSGKGGVAHLLRAHHGLDLPQAMRPDFSRTVQRVTDGTGR----ELTA---- 480 Query: 382 GKQQEEPEHFRLDYF---------SVQSGSNDIATAAVKLAC-----GEEVKAEAANGNG 427 E E FR Y +V + + A C G E GNG Sbjct: 481 ---GELGELFRTTYLAAAGQGSVEAVSWSTAETAPGVHTFTCVLRVDGREHSCR-GTGNG 536 Query: 428 PVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVES 487 P+ A+ A+ R V ++ Y A G D+ +G G G T ++ + Sbjct: 537 PLAALTDAL-RTAGVTVGVLGYWEHATTAGPDSPAAAYAECRVDGVTAWGAGWDTSVLTA 595 Query: 488 SAKAMVHVLN 497 S +++ +N Sbjct: 596 SVHSVLSAVN 605 >UniRef50_A8MBK1 Pyruvate carboxyltransferase n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8MBK1_CALMQ Length = 419 Score = 87.4 bits (215), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 96/386 (24%), Positives = 170/386 (44%), Gaps = 36/386 (9%) Query: 3 QQVIIFDTTLRDGEQALQA--SLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 ++ I DTT RDG+QA A VK ++ L+ + F + + D V Sbjct: 18 SELYITDTTFRDGQQAFYAYSPSDVKGLFKLLSELDNGSGRLSRSEFFLYTERDRRIVNA 77 Query: 61 I-ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + +K +V R +D+ + ES + ++ S +HI K +T V+ Sbjct: 78 VKGLGLKYPKVIGWGRARVEDVRLVKES----GLDEMVMLMSISDIHIKAKFNTTRARVV 133 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAIN---------AGATTINIPD 170 E+ + + A + S ED R AD+ V +N + I +PD Sbjct: 134 EKYLEAAEEAMRSGIALRCSLEDVTR---ADVLGFVVPFVNKLLRLRDKYGASLVIKLPD 190 Query: 171 TVGYTMPFEFAGI------ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 T G +P+ A + + + + I + H H D +AV N++AA GA Sbjct: 191 TTGVGVPYPTASLPYSIPKLIWVMRSLLKIPSNALEFHGHGDYHMAVANAVAAWVYGAGI 250 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNM--PIP 282 G + GIGERAGN +E +++ + + + E S++V M +P Sbjct: 251 NNGTLLGIGERAGNVPIEALVVWYS------RLKGSFDGMEPRVISRIVEYFKGMGYSVP 304 Query: 283 ANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMD 342 ++ IVGS A+A ++GIH D K+ E Y M P +G+ + L + +GR+ + H + Sbjct: 305 RHQPIVGSNAYATAAGIHIDAQSKDPETYLSMDPSLVGMRETIL-IGPYTGRSGIAHVLK 363 Query: 343 EMGYK--ESEYNLDNLYDAFLKLADK 366 +G +++ ++ +Y A ++L D+ Sbjct: 364 GIGVNAGKNDETVERVYRAVVRLYDE 389 >UniRef50_Q2GMU3 Putative uncharacterized protein n=1 Tax=Chaetomium globosum RepID=Q2GMU3_CHAGB Length = 828 Score = 86.3 bits (212), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 84/322 (26%), Positives = 141/322 (43%), Gaps = 33/322 (10%) Query: 8 FDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQ-TIARQVK 66 T LRDG QAL + + L +G +EVGFP SS DF+ Q + Sbjct: 59 LSTDLRDGNQALAS----------PMMLVDIGFKEIEVGFPASSEMDFQFAQRCVLDGPP 108 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 + + + C + I +++K A+ + +IATS I T +T + + A+ Sbjct: 109 DVWLEVMTPCRKDFIRRTVDAVKGAKKIIVSLYIATSDNFIDTIFSTTREAQLRTAVEHA 168 Query: 127 KRARNYTDD----------VEFSCE---DAGRTPIADLARVVEAAINAGATT---INIPD 170 + + T D + +S E D ++ R V+ A A +N+P Sbjct: 169 RYLKTVTKDDPAHKDTTWALMWSPEAFSDTDPDFAIEICRAVKEAWEPSAEVPIILNLPA 228 Query: 171 TVGYTMPFEFAGIISGLYERVPNIDKAI-ISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 TV + P FA + ++ R + D + +S+H H+D G AV + AGA +VEG + Sbjct: 229 TVEMSSPNIFADQVE-IFSRGFSGDPTVCVSLHNHNDRGCAVAAAELGQLAGATRVEGCL 287 Query: 230 NGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVG 289 G GER GN L V +A+ + + ++ ++ R ++V Q+ +P+ G Sbjct: 288 FGNGERTGNVDL--VTLALNLYTQ--GIDPGLDFSDLPRIRRIVEQLTQIPVHTRAPYAG 343 Query: 290 SGAFAHSSGIHQDGVLKNRENY 311 F SG HQD + K + + Sbjct: 344 DSVFVAYSGGHQDAINKGFKRW 365 >UniRef50_C1AUX2 2-isopropylmalate synthase n=8 Tax=Bacteria RepID=C1AUX2_RHOOB Length = 570 Score = 86.3 bits (212), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 98/379 (25%), Positives = 159/379 (41%), Gaps = 49/379 (12%) Query: 12 LRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR-QVKNSRV 70 LRDG QAL + + K + L +G +EVG+P +S DF+ V+ + R + V Sbjct: 50 LRDGNQALAEPMDPERKRRFFELLISIGYKEIEVGYPSASQTDFDFVRDLVRLDLVPDDV 109 Query: 71 CALARCVEKDIDVAAESLKVAEAFR---IHTFIATSPMH---IATKLRSTLDEVIERAIY 124 + +D D+ A + + E +H + AT+P + K R L +I A Sbjct: 110 TIVVFTAARD-DLIARTYESVEGLPNVVVHMYTATAPTWRSVVLGKDRKALHRLIFDAAQ 168 Query: 125 MVKRARNYTDDV--EFSCE-------DAGRTPIADLARVVEAAINAGATTINIPDTVGYT 175 V R + EFS E D L R+ +A+ + N+P TV + Sbjct: 169 EVARGAGDRPGLRFEFSPEVFNLTEPDFALEVCNSLTRLWDASPDR-PVIHNLPATVEVS 227 Query: 176 MPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGER 235 P +A I ++ + + + I+SVH H+D G V + AV AGA++VEG + G GER Sbjct: 228 TPNVYADQIEYMHRHLEDRESVILSVHPHNDRGTGVACAELAVLAGAQRVEGCLFGNGER 287 Query: 236 AGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAH 295 GN L V +A+ + V I+ +I + V +P+ G + Sbjct: 288 TGNVDL--VTLALNLHAQ--GVDPMIDLSDIDAVRRTVEYCNRIPVHERHPYGGDLVYTA 343 Query: 296 SSGIHQDGVLKNREN--------------------YEIMTPESIGLN-QIQLNLTSRSGR 334 SG HQD + K Y + P +G + Q + + S+SG+ Sbjct: 344 FSGTHQDAIKKGFAEHRASAEAAGLDPGSAPWAVPYLPIDPADVGRDYQAVIRINSQSGK 403 Query: 335 AAVKHRMDEMGYKESEYNL 353 + H + +SEY + Sbjct: 404 GGIAHLL------QSEYGI 416 >UniRef50_C8SJR8 Homocitrate synthase n=1 Tax=Mesorhizobium opportunistum WSM2075 RepID=C8SJR8_9RHIZ Length = 354 Score = 85.1 bits (209), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 98/305 (32%), Positives = 138/305 (45%), Gaps = 51/305 (16%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 MS QV + DTTLRDGEQA + +V EKL+IA +L GV +E+G P Sbjct: 1 MSSQVFLKDTTLRDGEQAPGVAFTVAEKLEIAESLAAAGVPEIEIGTPA------MGADE 54 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKL---RSTLDE 117 +AR + + R+ A R D++ A ES A ++ + S + +ATKL R+ + Sbjct: 55 VARSL-SVRLTAWCRMTSPDLEAAIESGVRA----VNLSFSASNIQLATKLGLDRAGALQ 109 Query: 118 VIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMP 177 +IE +MV RA V CEDA R L RV+ A AGA + + DT G P Sbjct: 110 LIE---HMVGRAAASGSSVAVGCEDASRADRDHLGRVIMTAARAGARRVRLADTAGVLDP 166 Query: 178 FEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 F +++ LAA+ AGAR + G+ ER G Sbjct: 167 FSTFELVA----------------------------QLAAIRAGARHASVTLLGLSERGG 198 Query: 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVG---SGAFA 294 N +LEEV A+ V + + H I+ + + V+Q P A K IVG S A Sbjct: 199 NAALEEVAAALAVLQ---HAHAGIDLTALPALAAKVAQASRRPTAATKPIVGAVPSKALR 255 Query: 295 HSSGI 299 S G+ Sbjct: 256 RSRGM 260 >UniRef50_Q97A78 2-isopropylmalate/homocitrate synthetase n=1 Tax=Thermoplasma volcanium RepID=Q97A78_THEVO Length = 344 Score = 84.0 bits (206), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 61/233 (26%), Positives = 111/233 (47%), Gaps = 23/233 (9%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 ++ D TLR+G QA + ++ EK++IA ++ + G+ V +P + + E+ + I Sbjct: 1 MLTDDTLREGMQAPGIAFTLDEKIRIAQSISKSGIKRALVSYPSAHESEVEAARKITDLH 60 Query: 66 KNSRVCALARCVEKDID-VAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 +L R +++D+D + + KV +H+ D I + Sbjct: 61 LFDDTYSLGRSIKEDVDSIISTGSKVT-------------LHLPFG-----DYDINKICD 102 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 +VK A +++D VE + D + + + + GA+ + IPDT G P ++ Sbjct: 103 VVKYASDHSDSVEIAIVDMVKYEKEKIFDLAKKLWECGASIVQIPDTTGRATPKRVHDVV 162 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 S + + + K + VH H+D GLA+ NS+A + AG V+ + GIGER G Sbjct: 163 SYIKQNL----KVKVEVHCHNDHGLAIANSIAGIEAGCDYVDTTIFGIGERNG 211 >UniRef50_A8A943 Pyruvate carboxyltransferase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=A8A943_IGNH4 Length = 488 Score = 82.0 bits (201), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 82/359 (22%), Positives = 158/359 (44%), Gaps = 24/359 (6%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVG---FPVSSPGDFES 57 + ++ I DTT RDG+QA + +V++ +++ L +G + ++ F + + D E+ Sbjct: 60 LPSEIWITDTTFRDGQQA-REPYTVEQIVRLYKYLHELGGPLGKIKTTEFFLYTEKDKEA 118 Query: 58 VQTIARQ-VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 V+ + K R ++++ + E A + S HI K +++ Sbjct: 119 VRRVKELGYKYPIPTGWIRAKKEELSLVKE----AGLEETGILASISDYHIYFKFKASRG 174 Query: 117 EVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLA-----RVVEAAINAG-ATTINIPD 170 +V+E+ + +V+ A ED R I ++ ++++ + G + PD Sbjct: 175 KVVEKYLSVVEEALKMDIIPRVHLEDITRANIFEVVVPFVRKLMKLSERYGLPVKVRYPD 234 Query: 171 TVGYTMPFEFAGI------ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 T+G +P A + ++ + V + + H H+D L V N+++A GA Sbjct: 235 TLGVGVPIVEAMLPRSIPKLTWVLRHVCGVPSEWLEFHGHNDFHLGVANAVSAWLYGAGL 294 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 G + GIGERAGN +E ++ A K + +N + I ++ +P Sbjct: 295 NNGTLLGIGERAGNVPIEALVFAYAQLKHGFD---GMNTKVITEIAKYYRDELGYEVPPY 351 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDE 343 IVG +GIH DG+LKN E Y E I + + +T +G A + + +++ Sbjct: 352 YPIVGRNFAVTRAGIHADGLLKNPETYLPFDTEGILGVKPGVAITPYAGLAGIVYWINK 410 >UniRef50_Q05FR2 2-isopropylmalate synthase n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FR2_CARRP Length = 447 Score = 82.0 bits (201), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 64/243 (26%), Positives = 115/243 (47%), Gaps = 17/243 (6%) Query: 12 LRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ---VKNS 68 LRDG Q+L ++K K+ I L +G + +GFP S+ DF + + + N Sbjct: 20 LRDGNQSLINGYNLKNKINIWEFLIEVGFKQIVLGFPSSNKHDFNFINYLKKNRLIPNNV 79 Query: 69 RVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEV----IERAIY 124 V L I++ +SLK E IH + + S + + +E+ I +Y Sbjct: 80 FVSVLTPAKTNSINLTIDSLKGIENSIIHLYNSISKIQRKLVFKMNKNEIKNFTINFFLY 139 Query: 125 MVKRARNYTDDVEFS------CEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 + + + ++S CE I + + IN + IN+P TV + Sbjct: 140 TISKIKKKNIIFQYSPESFSDCELIYSKKICYIFSYL-CYINNVKSIINLPITVENILSN 198 Query: 179 EFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGN 238 +F S LY + + +++SVHTH+D+G A+ +S+ ++ +G ++EG + G GER+GN Sbjct: 199 KFVN--SVLYIKKKKFN-SLLSVHTHNDMGGAITSSILSLLSGIDRIEGTLLGNGERSGN 255 Query: 239 CSL 241 ++ Sbjct: 256 SAI 258 >UniRef50_B9K380 Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Agrobacterium vitis S4 RepID=B9K380_AGRVS Length = 420 Score = 81.6 bits (200), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 82/317 (25%), Positives = 141/317 (44%), Gaps = 24/317 (7%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVD------VMEVGFPVSSPGD 54 +S +VI + RDG Q + L+ +++QIA + + V GFP + + Sbjct: 10 LSNRVIFHEEVARDGAQG-KTLLNGHQRVQIAKRHSSIFGEFAPYHLVFNAGFPSAGKDE 68 Query: 55 FESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRST 114 E+ + + V V A R +D+D+ +++ A RI + S + + T Sbjct: 69 LEATRQVVDCVDECYVGAAGRATRQDVDLLLQAVHGARHGRIFIAVPASNPMAYSMMHCT 128 Query: 115 LDEVIERAIYMVKRAR--NYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTV 172 ++ + A+ MV+ AR N V+ + DA R+ + LA AGA+ + + DTV Sbjct: 129 AEKAKQAALDMVRYARDKNPALMVDVALADASRSDVGFLAASAAEYAAAGASMVIVCDTV 188 Query: 173 GYTMPFEFAGIISGLYERV-PNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNG 231 G P E L R P++ H H+DLG + N+L A+ A + + Sbjct: 189 GQFFPSESRWFFDELARRSDPDLRYV---AHMHNDLGFGLVNTLEALSAKIYGLTSSWLS 245 Query: 232 IGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRT----------SQLVSQICNMPI 281 +GERAG + E+++ A+ + +L + EIWR+ ++ VSQ P+ Sbjct: 246 LGERAGMPATEQLLFALGYQSSLLPKKLGVV-DEIWRSPPDLRQLSPIARYVSQSTRRPL 304 Query: 282 PANKAIVGSGAFAHSSG 298 IVG+G S+G Sbjct: 305 MTTDPIVGTGVNTISTG 321 >UniRef50_A9A1R9 Pyruvate carboxyltransferase n=2 Tax=Archaea RepID=A9A1R9_NITMS Length = 352 Score = 81.6 bits (200), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 79/326 (24%), Positives = 143/326 (43%), Gaps = 39/326 (11%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 MS++V I DTTLRDG ++ S + + I LE+ G+ ++EVG Sbjct: 1 MSKKVQILDTTLRDGSYSVNFSFTSSDTSIICSKLEKSGIKLIEVG------------HG 48 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLK--VAEAFRIHTFIATSPMHIATK-----LRS 113 + NS + E+ + A ESL + F I S + +A K +R Sbjct: 49 LGFNASNSGYGKSTQSDEEYMIAAKESLSKSMYGMFCIPGIAKLSDLELAKKHGMGFIRV 108 Query: 114 TLDEV-IERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTV 172 D + ++ +K+A+N V + + P A +V+ + G + I D+ Sbjct: 109 GTDVTKVHQSEKFIKKAKNLGFFVASNFMKSYVMPPDKFASIVKQSEEFGTDMVYIVDSA 168 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G F+ + Y + N+ + + H HD+LG+A+ NSL A G ++ ++ GI Sbjct: 169 GGM----FSSDLLEYYNSIRNVSEIPLGFHGHDNLGMAISNSLYAADLGMEYIDSSLQGI 224 Query: 233 GERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQ-----LVSQICNMPIPANKAI 287 G +GN E ++MA+K + ++V + ++ Q L++ +P+ I Sbjct: 225 GRSSGNACTEVLVMALKKKGFKIDV----DFHSLFEAGQECVYPLINNSNKLPLD----I 276 Query: 288 VGSGAFAHSSGIHQDGVLKNRENYEI 313 V A HSS +H ++K +++ Sbjct: 277 VSGYADFHSSYMHH--IMKYSSKFKV 300 >UniRef50_Q46A99 Homocitrate synthase n=2 Tax=Methanosarcina RepID=Q46A99_METBF Length = 351 Score = 80.9 bits (198), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 55/170 (32%), Positives = 90/170 (52%), Gaps = 13/170 (7%) Query: 193 NIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIK--- 249 NI + + ++ G+A N+L+A+ AG V A++GIG G ++EEV+MA + Sbjct: 146 NITQCPVEYMGCNNYGMATANTLSALRAGVEYVATAVSGIG-IPGVAAMEEVLMAARHLW 204 Query: 250 VRKDILNVHT-AINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNR 308 + + N +T A + + I R + ++ +P KAI+G FAH SGIH DGV+KN Sbjct: 205 KNEQVPNGYTIAADCENILRRAGII-------LPGEKAIIGKNVFAHESGIHVDGVIKNP 257 Query: 309 ENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYD 358 YE + PE +GL++ L + SG A++ + ++ S L D Sbjct: 258 NLYEAIKPEEVGLSRF-LVIGKHSGTASLTQKFRQLDLSLSPQEAATLLD 306 >UniRef50_A9FUN7 Putative 2-isopropylmalate synthase n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9FUN7_SORC5 Length = 402 Score = 80.5 bits (197), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 74/260 (28%), Positives = 124/260 (47%), Gaps = 25/260 (9%) Query: 2 SQQVIIFDTTLRDGEQALQ-ASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 ++ V + D TLRDG Q + + S K+++ A+ +GVDV+ +G P + P F+ Sbjct: 106 ARPVEVLDETLRDGIQGVSIVNPSRARKIELLHAMASVGVDVVNLGMPATGPRQFDDACL 165 Query: 61 IARQVKNSRVC----ALARCVEKDID-VAAESLKVAEAFRIHTFIATSPM-HIATK---- 110 +AR++ SR+ A AR + D+D VA + + ++ FI +SP+ H Sbjct: 166 LAREIVASRLPLGLTAAARTLAADVDEVARVAERAGAPIMVYAFIGSSPIRHFVEGWGPD 225 Query: 111 -LRSTLDEVIERAIYMVKRARNYTDDVEFS--CEDAGRTPIADLARVVEAAINAGATTIN 167 L ++DE A + F EDA R+P L + AA++AGA + Sbjct: 226 FLARSVDEAGRAAAAAG---------LPFCLVAEDATRSPPDMLRTLFRAAVDAGAARLC 276 Query: 168 IPDTVGYTMPFEFAGIISGLYERVPNIDKAIISV--HTHDDLGLAVGNSLAAVHAGARQV 225 + DT G+ P +++ + + I + H H+D GL + +L AV +G +V Sbjct: 277 LCDTTGHVTPPGVEALVAFARRELGALGATGIELDWHGHNDRGLGLAAALWAVASGVERV 336 Query: 226 EGAMNGIGERAGNCSLEEVI 245 G+GER GN LE ++ Sbjct: 337 HATALGVGERTGNTCLELLV 356 >UniRef50_A4J5K5 Isopropylmalate/homocitrate/citramalate synthases-like protein n=1 Tax=Desulfotomaculum reducens MI-1 RepID=A4J5K5_DESRM Length = 125 Score = 80.5 bits (197), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 38/77 (49%), Positives = 54/77 (70%), Gaps = 1/77 (1%) Query: 151 LARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNI-DKAIISVHTHDDLGL 209 + +EA + AGAT IN+PDTVGY +P EF +I +++ + N+ DK ++SVH H+DLGL Sbjct: 1 MWNTIEAVVKAGATIINVPDTVGYAVPEEFGELIRNIHDCLKNLNDKVLLSVHCHNDLGL 60 Query: 210 AVGNSLAAVHAGARQVE 226 A N+L AV GA +VE Sbjct: 61 ATANTLIAVKNGADKVE 77 >UniRef50_B4WHZ2 HMGL-like domain protein n=1 Tax=Synechococcus sp. PCC 7335 RepID=B4WHZ2_9SYNE Length = 411 Score = 80.5 bits (197), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 92/334 (27%), Positives = 147/334 (44%), Gaps = 42/334 (12%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 ++I D TLRDGEQ Q L ++K +A + + GV + + P + + V ++ Sbjct: 6 LLISDETLRDGEQ--QVGLFFEDKTTLANLIAQTGVQQIAL-MPAIHTSEAKLVSSLVDS 62 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHT----FIATSPMHIATKLR---STLDE 117 ++ A I+ A++ V + H + + IA R T+D+ Sbjct: 63 GLKRQIVASTMMRRAAIE-HAKTCGVRQVILFHAVSDRLLFLRDLEIAKDPRFKGKTIDD 121 Query: 118 VIERAIYMVKRARNYTDDVE-------------FSCEDAGRTPIADLARVVEAAINAGAT 164 I+ + R R +E F+ EDA R AD +VE IN + Sbjct: 122 DIDLPVIQRSRQRMLIHALEHVRYAAEQGLRICFAAEDASR---ADNDFLVEC-INTLSP 177 Query: 165 TIN---IPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAG 221 I+ + DTVG P A I L + + +SVH H+D+GLA+ N++ AV AG Sbjct: 178 YIDEFLLCDTVGSLTPKRTALWIQNLLQHTRAVP---LSVHFHNDMGLALENTIQAVCAG 234 Query: 222 ARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTA-INHQEIWRTSQLVSQICNMP 280 AR + G GIGERAGN +E+V+ ++ R A I++ + + + + P Sbjct: 235 ARGISGTFGGIGERAGNAPIEQVLKGLRSR---FGWEVAGIDYDALDQVVDYLHAQGHRP 291 Query: 281 IPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIM 314 A A H SGIH +L++R +Y I Sbjct: 292 ----HAPYSRQAQRHESGIHVSALLRDRRSYSIF 321 >UniRef50_B8H935 Pyruvate carboxyltransferase n=7 Tax=Actinomycetales RepID=B8H935_ARTCA Length = 326 Score = 80.1 bits (196), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 79/271 (29%), Positives = 121/271 (44%), Gaps = 35/271 (12%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M + I+ D TLRDG Q LS + K++ L R+GV +E+G S + V T Sbjct: 8 MLAKTILRDVTLRDGLQLTGKVLSTERKVETVRELIRLGVPAIELG----SMARADLVPT 63 Query: 61 IARQVKNSRVCA---LARC---VEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRST 114 +A ++ + L +C V VA S A F+ + A+ + A R+T Sbjct: 64 MANTLEVVQALTPEELEKCWIWVATPGHVAKASAAGARNFQ-YCLSASDSHNKANIGRTT 122 Query: 115 LDEVIERAIYMVKRARNYTDDV----------EFSCEDAGRTPIADLARVVEAAINAGAT 164 E ++ + A YT V F+C G P + + G T Sbjct: 123 -----EESLAALPEAVTYTQSVNGQIQLCIATSFTCPFEGYVPEERILSIANDPRAEGTT 177 Query: 165 TINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 I + DT+G +P + AG+I+ + E P I H HD GL V N+LAA+ AGA Sbjct: 178 DIVLCDTLGQAIPTQVAGLINRVREESP---ARRIVYHGHDTWGLGVANTLAAIQAGAAM 234 Query: 225 VEGAMNGIG------ERAGNCSLEEVIMAIK 249 V+GA+ G+G +GN S E+++ A + Sbjct: 235 VDGALGGLGGCPFAPGASGNTSTEDILFATR 265 >UniRef50_B8G187 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Desulfitobacterium hafniense DCB-2 RepID=HOA_DESHD Length = 333 Score = 76.6 bits (187), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 76/266 (28%), Positives = 121/266 (45%), Gaps = 37/266 (13%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVG-----------FPVSS 51 ++V IFD TLRDG A + ++ +A ++ GV +E G + ++ Sbjct: 2 KKVKIFDLTLRDGSHAKSHQFTPEQMAVLAEQIDSTGVAAIEFGHGNGLGGSALQYGFAA 61 Query: 52 PGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKL 111 D E ++ +A VKN+ L+ + + E L +A+ F + T++ Sbjct: 62 ATDREYMEAVAPVVKNAD---LSIIILPGVGTRHE-LHLAKEF------GAKYARMCTQI 111 Query: 112 RSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDT 171 ++ E+ I M K+ V C AG P+ D R + A + GA I + D Sbjct: 112 TEV--DIAEQHIKMAKQLGMIPIAV-LPC--AGIIPVKDTVRYTQMAESYGAEVIYLLDG 166 Query: 172 VGYTMPFEFAGIISGLYERVPNIDKAI---ISVHTHDDLGLAVGNSLAAVHAGARQVEGA 228 GY +P + YER+ + KA+ I H H++L LAV NS AAV AGA ++ Sbjct: 167 GGYQLPEQ-------TYERIAAMKKAVDVPIGFHGHNNLQLAVANSKAAVEAGAEYIDCC 219 Query: 229 MNGIGERAGNCSLEEVIMAIKVRKDI 254 + G G AGNC E+ A+ R +I Sbjct: 220 LKGFGAGAGNCP-TEIFAAVMDRMEI 244 >UniRef50_A4QUQ8 Putative uncharacterized protein n=1 Tax=Magnaporthe grisea RepID=A4QUQ8_MAGGR Length = 633 Score = 76.6 bits (187), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 80/325 (24%), Positives = 138/325 (42%), Gaps = 24/325 (7%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFES--- 57 +++ I T LRDG Q+L A L+ +K + L +G +EV FP +S +FE Sbjct: 10 ITKAPIWLSTDLRDGNQSLTAPLNSDQKFEFFKLLVEIGYKEIEVSFPAASNVEFEFTRR 69 Query: 58 -VQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 V+T + R+ ALA + ++L+ A+ + T+I S + + S Sbjct: 70 LVETPGAVPDDVRLRALAPTRNDFLKRTVDALEGAKRATVCTYICVSDKMLKYQGFSRA- 128 Query: 117 EVIERAIYMVKRARNYTDD---------VEFSCEDAGRTPIADLARVVEAAINAGATTIN 167 IE+A+ V+ R+ T D + F E + + EA + A + + Sbjct: 129 RAIEQAVGAVRYLRSITKDNPDTKTRWDLAFGLESYNESDQDFALAMTEAVMGAWEASAD 188 Query: 168 ------IPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAG 221 + + P FA + + + +IS+HTH D G + + AG Sbjct: 189 DQMWVVLATSTEVATPNVFADQVETFIAGLSAPENVLISIHTHSDRGCGAAAAELGMLAG 248 Query: 222 ARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPI 281 A VEG + G GERAGN L V +A+ + ++ H ++ +++ Q+ + + Sbjct: 249 AHMVEGCLFGNGERAGNVDL--VTLALNLYTRGISPH--LDFSDLYAVRDRYEQLTGLQV 304 Query: 282 PANKAIVGSGAFAHSSGIHQDGVLK 306 A G A SG HQ+ + K Sbjct: 305 TARTPYAGEYALQAFSGHHQNIIRK 329 >UniRef50_A7NPM1 Pyruvate carboxyltransferase n=2 Tax=Roseiflexus RepID=A7NPM1_ROSCS Length = 707 Score = 73.9 bits (180), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 83/266 (31%), Positives = 123/266 (46%), Gaps = 38/266 (14%) Query: 13 RDGEQALQA-SLSVKEKLQIALALERMGVDVMEV-GFPVSSPGDFESVQTIARQVKN--- 67 RDG LQ L+V E + ++ +GV V+E+ FP + PG + + + R + Sbjct: 258 RDG--TLQGFHLTVDEAWEAVRGMDSLGVGVIELPSFPANPPGQAFNRRLLERAAAHGLT 315 Query: 68 SRVCALARCVEKDIDVAAESLKVAEAFR-IHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 + A ARCV DI AAE+ FR +H +I SP+ AT + + ++ ++A + Sbjct: 316 TTFAAHARCVAADIRTAAET-----GFRRLHLYIGVSPIKQATAHANAV-QLADKAFDAI 369 Query: 127 KRARNYT-DDVEFSCEDAGRTPIADLA----RVVEAAINAG--ATTINIPDTVGYTMPFE 179 AR+ D V S EDA RTP+ D R+ E + G I IPDTVG Sbjct: 370 HLARDLGFDCVRISTEDAYRTPLDDYCAFYERLQERLTSHGLHVDGIGIPDTVG------ 423 Query: 180 FAGIISGLYERVP-----NIDKAIISVHTHDDLG----LAVGNSLAAVHAGARQV-EGAM 229 G I L +R+ I + H H+D+G L V L + G + + ++ Sbjct: 424 -VGTIDDLGDRIAVLRQVGIRFVFLECHIHNDIGHSDRLYVDTLLLCMRLGIMMLPDFSI 482 Query: 230 NGIGERAGNCSLEEVIMAIKVRKDIL 255 GIGER G L +I AI R +L Sbjct: 483 LGIGERNGTIGLSSLIEAIYRRLLLL 508 >UniRef50_Q2LTE1 Isopropylmalate/homocitrate/citramalate synthases n=43 Tax=Bacteria RepID=Q2LTE1_SYNAS Length = 634 Score = 73.6 bits (179), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 84/369 (22%), Positives = 150/369 (40%), Gaps = 48/369 (13%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVD---VMEVGFPVSSPGDFESV 58 ++++ I DTT RDG+QA + + ++ + + + R+G + + F + S D E+V Sbjct: 61 AEEIFITDTTFRDGQQA-RPPYTTQQIVDLYQMMSRLGGYNGIIRQTEFFLYSNRDKEAV 119 Query: 59 QTIARQ-VKNSRVCALARCVEKDIDVAAES-LKVAEAFRIHTFIATSPMHIATKLRSTLD 116 + ++ + R +DI + E+ LK + S HI KL T Sbjct: 120 RMCQDLGLQYPEITGWIRAAREDIPLVKEAGLK-----ETGILTSVSDYHIFLKLNMTRS 174 Query: 117 EVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATT----------- 165 + +E + +VK + DAG P + A I Sbjct: 175 QALEEYLGIVK-----------AILDAGIVPRCHFEDITRADIYGFCIPFAIELMKLREE 223 Query: 166 ------INIPDTVGYTMPFEFAGIISGLYERV-PNIDKA-----IISVHTHDDLGLAVGN 213 I + DT+GY + + A + G+ + V ID A ++ H H+D A+ N Sbjct: 224 SGVDIKIRLCDTMGYGVTYPGASLPRGVDKLVRAFIDDADVPGRLLEWHGHNDFHKALIN 283 Query: 214 SLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLV 273 + A G + G+GER GN +E +I+ ++ I+ I + Sbjct: 284 ATTAWLYGCSAANSTLLGLGERTGNPPIEGLIIEYI---GLMGKTNGIDTTVITDIANYF 340 Query: 274 SQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSG 333 IP+N VG+ +G+H DG++K+ E Y I I I +T +SG Sbjct: 341 KNEIEYKIPSNYPFVGADFNVTRAGVHADGLIKSEEIYNIFNTTKILKRPIVPMITDKSG 400 Query: 334 RAAVKHRMD 342 +A + + ++ Sbjct: 401 KAGIAYWIN 409 >UniRef50_UPI000038E183 2-isopropylmalate synthase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E183 Length = 345 Score = 73.2 bits (178), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 65/263 (24%), Positives = 111/263 (42%), Gaps = 26/263 (9%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 ++ D TLR+G Q ++S EK+++A + G+ V +P + +FE I Sbjct: 1 MLTDDTLREGMQTPGFAMSYDEKIELAKLISSAGIKRALVAYPPAHKSEFEVTAAIVDGK 60 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 +V L R V++DID+ E+ A +H+ KL + +V E Sbjct: 61 YFQQVFGLGRTVKEDIDMINETG------------ANISLHLPFKL-DNMGQVYEN---- 103 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 +K A VE D + + + + +PDT G P I Sbjct: 104 IKYACTLGKIVEIGFVDIDMFSVEQITKFCHKMEELNVDVVQLPDTRGKMNP----AAIK 159 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG---NCSLE 242 ++E I H H+D G+AV N+++A+ AG ++ + G GER G + +L Sbjct: 160 NVFEAAKKATNIKIEAHCHNDYGMAVANTISAISAGVDYIDTTIFGTGERNGIADSITLA 219 Query: 243 EVIMAIKVRK--DILNVHTAINH 263 + +M + K DI + A N+ Sbjct: 220 DYLMKNNLEKSLDIKGIIKAYNY 242 >UniRef50_A5LD67 2-isopropylmalate synthase/homocitrate synthase family protein n=1 Tax=Streptococcus pneumoniae SP3-BS71 RepID=A5LD67_STRPN Length = 198 Score = 73.2 bits (178), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 56/204 (27%), Positives = 105/204 (51%), Gaps = 18/204 (8%) Query: 199 ISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVH 258 I H H+DLGLAV N+L+A+ +GA V GIGER GN S E++I+ + V + Sbjct: 5 IEWHGHNDLGLAVSNALSAIESGADIVHTCTLGIGERCGNTSTEQLIINLIVSE--CGRR 62 Query: 259 TAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV----LKNRENYEIM 314 + ++ ++++ PI G +F +G H + LKN N+ I+ Sbjct: 63 ATYKLRYLYDVAKILENKSQFPISPKTPCFGMDSFFTCAGTHASSLYKSYLKNDNNFSII 122 Query: 315 -TP--ESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVF 371 +P +I ++ + + S+SGR+++++ + G + S+ N+ ++ L L K+ +F Sbjct: 123 FSPYDSNIFGREVTVGINSQSGRSSIEYISRKYGLELSQENITSI----LGLV-KQNDLF 177 Query: 372 DYDLEALAFIGKQQEEPEHFRLDY 395 + E + ++ +++ E RLDY Sbjct: 178 FREEEFVDYVKQKRVE----RLDY 197 >UniRef50_C8WQC0 Pyruvate carboxyltransferase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WQC0_ALIAD Length = 301 Score = 72.4 bits (176), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 70/272 (25%), Positives = 119/272 (43%), Gaps = 45/272 (16%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVG---FPVSSPGDFES 57 M ++V + + RDG Q ++ + K+++ L GV +EV P P ++ Sbjct: 1 MGERVWLREVGPRDGLQNEPGVIATEIKVELVERLMDAGVRFIEVSSFVHPKWIPQLADA 60 Query: 58 VQTIAR-----------QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMH 106 + AR V N R LAR + +D +H F++ S H Sbjct: 61 DEVFARIRRRPGVELSALVPNER--GLARALAAKVDA------------VHVFMSASESH 106 Query: 107 IATKLRST-------LDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAI 159 + T L VIE A R Y V F C G+ P++ + VVE Sbjct: 107 NLKNINKTIADTYPVLRPVIEGAKAEGLVVRGYVSTV-FGCPYEGKVPVSQVLSVVERLF 165 Query: 160 NAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVH 219 G + + DT+G +P + A ++ + ER+ +D+ +S+H HD G+A+ N A Sbjct: 166 ELGVDEVALGDTIGVAVPTQVAEVVREV-ERIVPLDR--VSLHFHDTRGMAIANMYAGFA 222 Query: 220 AGARQVEGAMNGIG------ERAGNCSLEEVI 245 AG R+ +G++ G+G +GN ++E+V+ Sbjct: 223 AGVRRFDGSIGGLGGCPYAPGASGNVAMEDVL 254 >UniRef50_Q97MD8 Homocitrate syntase, omega subunit nifV (NivO) n=1 Tax=Clostridium acetobutylicum RepID=Q97MD8_CLOAB Length = 356 Score = 71.6 bits (174), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 54/175 (30%), Positives = 87/175 (49%), Gaps = 22/175 (12%) Query: 190 RVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIK 249 R+ N +++ + +A S+ A++ GA + A NG ER G S EEVI+A+K Sbjct: 157 RIKNTFCSLVDFCASNKYFMATAISMEALNDGADFITVAFNG--ERYGISSFEEVILALK 214 Query: 250 VRK--------DILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 V K D+LN + I +++++R + I K I+G F + SGIH Sbjct: 215 VMKKVKVTEKLDLLNDLSKI-YEKLFRKA----------ISPMKPIIGEDIFKYESGIHV 263 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNL 356 DG+ KN YE P IG ++ Q+ + SGR AV+ ++ E+ + N+D Sbjct: 264 DGIEKNPLTYEPYEPSIIGADR-QMFIGKHSGRKAVEIKLRELNIETMLCNMDKF 317 >UniRef50_C0QM22 LeuA1 n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QM22_DESAH Length = 369 Score = 71.6 bits (174), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 77/288 (26%), Positives = 121/288 (42%), Gaps = 44/288 (15%) Query: 36 ERMGVDVMEVGFPVSSPGDFESVQTIARQVKNS--------RVCALARCVEKDIDVAAES 87 ER+GVD+ + G+P + ES Q + + S RV A+ R +D+ +E+ Sbjct: 21 ERLGVDICQAGYPPAH----ESEQAKLKHLSASAVEKGYSIRVAAMGRACLEDVQTLSET 76 Query: 88 LKVAEAFRIHTFIA----TSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDA 143 + F +H ++ SPM A T E I RA + + D Sbjct: 77 GTLD--FHLHAHVSKEKWNSPMDQAFPDLGTTVETI--------RANCPGSQISLAFLDI 126 Query: 144 GRTPIADLARVVEAAINAGATTI-NIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVH 202 GRT L+R I A I ++PDT G P + I+ + R+ ++VH Sbjct: 127 GRTDPEFLSRAALYLIKELALDILSLPDTSGIMGPNQVHDAIAPI-ARLSRNSSTRLAVH 185 Query: 203 THDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDI-----LNV 257 H+DLG+A N++ V AGA VE ++ G+GER G L ++ +V KD L + Sbjct: 186 CHNDLGMASANTVMGVVAGATVVEASVFGLGERNG---LADLYTTARVLKDQGYALDLRL 242 Query: 258 HTAINHQEIWRTSQLVSQICNMP-----IPANKAIVGSGAFAHSSGIH 300 +E +R + +C + N G G H +G H Sbjct: 243 EDVDTFREYYR---YIDGVCRQQTGEPLLTYNTPFFGDGVKTHVAGTH 287 >UniRef50_B1VRH5 4-hydroxy-2-oxovalerate aldolase n=14 Tax=cellular organisms RepID=HOA_STRGG Length = 340 Score = 71.6 bits (174), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 79/310 (25%), Positives = 133/310 (42%), Gaps = 57/310 (18%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVG-----------FPVSS 51 +QV+I D TLRDG+ A+ L + E + A A + V V+EVG +++ Sbjct: 2 KQVVIHDPTLRDGQHAVHHRLGLTELRRYAEAADAARVPVVEVGHGNGLGASSLQVGLAA 61 Query: 52 PGDFESVQTIARQVKNSRVCA-----------LARCVEKDIDVAAESLKVAEAFRIHTFI 100 D + T+ +++SR+ L R + +DV FR+ Sbjct: 62 ATDDAMLSTVREALRHSRLGTFMLPGWGTSDDLRRAISHGVDV----------FRV---- 107 Query: 101 ATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAIN 160 + +T + E + ++ A V A +P +LA A+ Sbjct: 108 ---------GVHATEASLAEHHLGFLRDAGAEAHCVLMMSHMA--SP-GELAEQAARAVG 155 Query: 161 AGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHA 220 GA + I D+ G+ +P + I + E V + + H H++LG+AV NS+AA A Sbjct: 156 YGAQAVGIMDSAGHFLPPDVTARIGAIVEAVGTVP---VIFHGHNNLGMAVANSVAAAEA 212 Query: 221 GARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQ--ICN 278 GAR ++G G G AGN L EV++ + R T I+ + + L + + Sbjct: 213 GARIIDGCARGFGAGAGNTQL-EVLVPVLERSGFA---TGIDLYALLDAADLAERELMPA 268 Query: 279 MPIPANKAIV 288 P+PA+ +IV Sbjct: 269 PPVPASMSIV 278 >UniRef50_C0GGI7 Pyruvate carboxyltransferase n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GGI7_9FIRM Length = 307 Score = 71.2 bits (173), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 67/291 (23%), Positives = 134/291 (46%), Gaps = 25/291 (8%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEV-GF--PVSSPGDFES 57 +S V+I + LRDG Q + ++ ++K+++A AL G+ +E+ F P + P ++ Sbjct: 7 LSGDVLIREVGLRDGLQNEKQFVATEDKIRLARALTAAGLREIEITSFVSPKAVPQMRDA 66 Query: 58 VQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + +A + V A V + AE + + ++ S H +R ++DE Sbjct: 67 KEIVAALGQPEGVTYSALVVNRR---GAEDAIASGVKELQYVVSCSETHSQKNVRMSVDE 123 Query: 118 VIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIPDT 171 +++A + A+ + F C G+T + ++E + G +++ DT Sbjct: 124 ALQQAAIISDLAKENGLTIRTALSATFGCPFEGKTSYDRVYDLLEKLFSLGVERVSLSDT 183 Query: 172 VGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNG 231 G P + A + G+ R P D+ S+H HD GL + +LA V AG R +E ++ G Sbjct: 184 AGLGNPRQVAQLCQGIVARFPE-DR--FSLHLHDTRGLGLACTLAGVWAGIRVIESSIGG 240 Query: 232 IG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQI 276 +G GN + E+V+ ++ + + T ++ Q++ + + +I Sbjct: 241 LGGCPFVPNATGNIATEDVVYMMEE----MGISTGLDWQQLMNAAMMAEKI 287 >UniRef50_D2S7Y3 Pyruvate carboxyltransferase n=3 Tax=Actinomycetales RepID=D2S7Y3_9ACTO Length = 311 Score = 68.6 bits (166), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 42/153 (27%), Positives = 72/153 (47%), Gaps = 13/153 (8%) Query: 138 FSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKA 197 + C GRTPI V A + AGA + + DT+G T P ++ + P ++ Sbjct: 150 WDCPFDGRTPIPRTVDVARAVVTAGADRLCLGDTIGTTTPMRVVQLLDAVRRACPGVE-- 207 Query: 198 IISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIG------ERAGNCSLEEVIMAIKVR 251 + VH HD G N+LAAV AG Q++ ++ G+G +GN + EE++ ++ Sbjct: 208 -VGVHFHDTRGTGQANALAAVQAGVTQLDSSVGGLGGCPFAPGASGNIATEELVYMLEES 266 Query: 252 KDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 V T I+ + +++ Q P+P + Sbjct: 267 ----GVRTGIDLDAVLAAARVTEQAVGRPLPGS 295 >UniRef50_A3P825 4-hydroxy-2-oxovalerate aldolase n=20 Tax=Burkholderia RepID=HOA_BURP0 Length = 347 Score = 68.6 bits (166), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 72/261 (27%), Positives = 113/261 (43%), Gaps = 40/261 (15%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVG-----------FPVSSPG 53 ++I D TLRDG A++ LS + A A + G+DV+EVG + G Sbjct: 2 ILISDATLRDGNHAIRHQLSAAQIHAYARAADEAGIDVVEVGHGNGLGGSSCLLGQTPIG 61 Query: 54 DFESVQTIARQVKNSR-----VCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIA 108 D ++T ++ SR + L + DI +A E I + +A Sbjct: 62 DRLMLETARAALRTSRLGVHFIPGLGKAA--DISLALE-------------IGVDVVRVA 106 Query: 109 TKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINI 168 T T V R I + A V A + A+++E GA + + Sbjct: 107 TH--CTEANVSARFIEQTRTAGRTAFGVLMMSHMAPPDTLLAQAKLME---RYGAQAVVL 161 Query: 169 PDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGA 228 D+ GY+ P ++ ER+ + + H H++LGLAV NSL A+ AGAR V+ Sbjct: 162 MDSAGYSTP----SLVRAKVERLVDGLDIDVGFHAHNNLGLAVANSLVALEAGARIVDAC 217 Query: 229 MNGIGERAGNCSLEEVIMAIK 249 + G G AGN LE ++ A++ Sbjct: 218 VKGFGAGAGNTQLETLVAAME 238 >UniRef50_B9LMV8 Pyruvate carboxyltransferase n=1 Tax=Halorubrum lacusprofundi ATCC 49239 RepID=B9LMV8_HALLT Length = 314 Score = 68.6 bits (166), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 60/246 (24%), Positives = 107/246 (43%), Gaps = 27/246 (10%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEV-------GFPVSSPGDF 55 V + + RDG Q L + EK++I AL GVD +E+ P D Sbjct: 6 SDVTLVEMLPRDGFQRLDEFVPTDEKVEIIDALSETGVDEIEITSFTHPKAVPTLRDAD- 64 Query: 56 ESVQTIARQ--VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRS 113 E Q I R V + A +E+ ID + +++ + S + Sbjct: 65 EVAQRIERHDDVTYRALVPNAVGMERAIDAGVD--------KVNALVTVSETYSEHNQNM 116 Query: 114 TLDEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTIN 167 T++E++ +V+ A +VE F C GR P+ D VV+ ++AG + Sbjct: 117 TVEEILTGVEEIVEMAEGTGIEVEAGMGTSFYCPYEGRIPMEDTLSVVDRVVDAGVDEVT 176 Query: 168 IPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEG 227 + T+G P E + + +++R P++D + H HD G+++ N+L A+ G + + Sbjct: 177 LATTMGLADPVEIEEMYTTVFDRHPDLDAGL---HLHDTNGMSLANTLVAMQCGVDRFDA 233 Query: 228 AMNGIG 233 + G+G Sbjct: 234 SHCGLG 239 >UniRef50_Q1IW44 HMGL-like domain protein n=4 Tax=Bacteria RepID=Q1IW44_DEIGD Length = 436 Score = 68.6 bits (166), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 96/359 (26%), Positives = 148/359 (41%), Gaps = 50/359 (13%) Query: 9 DTTLRDGEQALQASLSVKEKLQIALALERMGVD---VMEVGFPVSSPGD---FESVQTIA 62 +TT RDG+Q L+ + L I + + D + + F V P D E Sbjct: 47 ETTHRDGQQG-GLPLTTADGLAIYDLMGKFTGDSGAIRQAEFFVYRPADRAMLEGALERW 105 Query: 63 RQVKNSRVCALARCVEKDIDVAAE-----SLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 R R +D ++ AE + +A A HTF +P A R+ LD Sbjct: 106 RGGHPVEPTTWIRATRRDAELVAELGVRETGMLASASDYHTFYKFTPGGRAQAARTYLDA 165 Query: 118 VIERAIYMVK-RARNYTDDVEFSCEDAGRTP-------IADLARVVEAAINAGATTINIP 169 V RA+ R R EDA R P +A + V A A + Sbjct: 166 V--RAVLDAGLRPR-------LHLEDATRAPREFILPFVAAVQEVSAPYGEAQAPKFRVC 216 Query: 170 DTVGYTMPFEFAGIISGLYER-VPNIDKAIIS---------VHTHDDLGLAVGNSLAAVH 219 DT+G +P E G+ + R VP + + +++ H H+D L V N LAAV Sbjct: 217 DTMGVGLPLE--GVA---WPRSVPGMIRELVAAGVPGEQLEFHPHNDTHLVVANCLAAVI 271 Query: 220 AGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNM 279 AG + G + G GER GN LE V++ + +L +++ + + L ++ Sbjct: 272 AGCAAINGTLLGKGERTGNAPLEGVLLHLIGLNLLLG---QPDYRALNELADLYERLGQG 328 Query: 280 PIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIM-TPESIGLNQIQLNLTSRSGRAAV 337 +PA + G A +GIH DG+ K Y P+ +G ++L+LT SG A + Sbjct: 329 -VPAKYPLYGRDAHRTRAGIHADGLNKFWPMYAPFDVPQLLG-RPLELSLTKDSGLAGL 385 >UniRef50_C9P0G7 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Vibrio coralliilyticus ATCC BAA-450 RepID=C9P0G7_9VIBR Length = 354 Score = 67.4 bits (163), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 64/253 (25%), Positives = 117/253 (46%), Gaps = 35/253 (13%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVG-----------FPVSSPGDF 55 I + TLRDG + S K IALAL+ G +++EVG V+ D Sbjct: 6 ILECTLRDGSYEIDFQFSKKNADDIALALDEAGFELIEVGHGVGLGATEKKIGVALESDE 65 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 +++ A V N + A + E L++A+ + + FI ++ ST+ Sbjct: 66 VYMKSAAESVTNGKWGMFAIPGIATL----EHLEMAKNYDM-DFI---------RIGSTI 111 Query: 116 DEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIA---DLARVVEAAINAGATTINIPDTV 172 ++ + + V A++ +C + ++ A DLA+ + A G + + D+ Sbjct: 112 EDFPKSEAF-VSSAKSQG---MMTCANFMKSYAAKPEDLAQASKLAFEMGVDAVYVVDSA 167 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G +P E + + + A+I H H++LGL +GN+LAA+ AGA ++ ++ G Sbjct: 168 GGMLPNEVKLYVEAILAEKSD---AVIGFHGHNNLGLGIGNALAAIEAGASIIDTSLQGF 224 Query: 233 GERAGNCSLEEVI 245 G AGN + E+++ Sbjct: 225 GRSAGNTTTEQML 237 >UniRef50_Q5WKL8 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillaceae RepID=Q5WKL8_BACSK Length = 309 Score = 67.4 bits (163), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 74/287 (25%), Positives = 122/287 (42%), Gaps = 40/287 (13%) Query: 13 RDGEQALQASLSVKEKLQIALALERMGVDVME-VGFP----VSSPGDFESVQTIARQVKN 67 RDG Q Q LSV++K+++ R G+ +E V F V + D E V + + Sbjct: 21 RDGLQNEQVRLSVEQKIEMMEHAARSGISKIEAVSFVNKKLVPAMADAEEVMAAWHRREG 80 Query: 68 SRVCALA-------RCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 R+ LA R ++ IDV ++ ++AF T +A L L V E Sbjct: 81 VRIAGLALSRSGITRALQTPIDVLHITISASDAFNKRNANKT----VAEGLSDLLPVVGE 136 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 + ++ T F C +G + + V E+ + AGAT + + DT G P + Sbjct: 137 ASTHLPVVTVISTS---FGCPFSGDVQMETVFSVCESFLKAGATEMVLADTTGMANPRQV 193 Query: 181 AGIISGLY----ERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIG--- 233 A + G Y E +P + +H H+ GL + N++A AG R+ + A+ G+G Sbjct: 194 AETVRGFYRTFGEDIP------LGLHFHNTRGLGLANAVAGYDAGVRRFDSAVGGLGGCP 247 Query: 234 ---ERAGNCSLEEVI-----MAIKVRKDILNVHTAINHQEIWRTSQL 272 + GN E+++ M I D+ + T E W +L Sbjct: 248 FAPKATGNICTEDLVHMFHEMGIDTGTDLDGLITLAQQVEKWMGKRL 294 >UniRef50_C5RN58 NifV2 n=1 Tax=Clostridium cellulovorans 743B RepID=C5RN58_CLOCL Length = 349 Score = 66.2 bits (160), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 52/162 (32%), Positives = 85/162 (52%), Gaps = 20/162 (12%) Query: 199 ISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKD--ILN 256 IS + L +A +L + G + G NG E G S+EEV++A+KV KD I+ Sbjct: 168 ISFCASNRLNMATAVTLEGLLDGNEMIIGTFNG--EVYGVASIEEVLLALKVIKDYKIIG 225 Query: 257 VHTAI-----NHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENY 311 + I N+QE+ TS+ +S+I K ++G F SGIH DG++K+ Y Sbjct: 226 DISGIKKLTQNYQEL--TSENISRI--------KPVIGEEIFNFESGIHADGIIKSPLTY 275 Query: 312 EIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNL 353 E PE +G N+ ++ + SG A+++R+ ++ S+ NL Sbjct: 276 EPYEPELVGTNR-RMIIGKHSGTKAIEYRLMQLNILSSDVNL 316 >UniRef50_A9F2G5 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacteria RepID=A9F2G5_SORC5 Length = 328 Score = 65.9 bits (159), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 68/305 (22%), Positives = 131/305 (42%), Gaps = 37/305 (12%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP-----GDF 55 ++ +V I++ + RDG Q A + ++ K ++ AL G+ +E+ VS D Sbjct: 24 VADEVSIYEVSPRDGLQNESAMIPIEGKRRLIAALVGAGLRRIEITSFVSPKWVPQLADA 83 Query: 56 ESV-QTIA--RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLR 112 E + +T+ R V S +C AR +E+ + V + V F++ S H + Sbjct: 84 EELARTLPAERGVTFSALCPNARGLERALAVGLREIAV--------FLSASEAHNRANIN 135 Query: 113 STLDEVIERAIYMVKRARN-------YTDDVEFSCEDAGRTPIADLARVVEAAINAGATT 165 ++D+ + +V AR Y V + C G A + R+ E I+ G Sbjct: 136 KSIDDTLSVFSEIVPPAREAGLAVRAYVSTV-WGCPYEGDVDPARVVRIAERLIDLGCYQ 194 Query: 166 INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQV 225 +++ DT+G P + I+ + +P ++H HD G A+ N L + G R Sbjct: 195 VSLGDTIGVGTPRQTHDIVRRFLDAMP---PERFALHLHDTRGTALANILVGLELGVRDF 251 Query: 226 EGAMNGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNM 279 + ++ G+G AGN + E+++ + + V T ++ ++ + Q+ Sbjct: 252 DASVAGVGGCPYAPGAAGNMATEDLVFMLHG----MGVRTGVDLDKVIEAGNVAEQVIGR 307 Query: 280 PIPAN 284 P+P Sbjct: 308 PLPGK 312 >UniRef50_D0Z8X0 Putative hydroxymethylglutaryl-CoA lyase n=1 Tax=Edwardsiella tarda EIB202 RepID=D0Z8X0_EDWTE Length = 312 Score = 65.1 bits (157), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 65/269 (24%), Positives = 121/269 (44%), Gaps = 38/269 (14%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + V + + + RDG Q ++ + + K+ I + R GV +EV F S + Sbjct: 11 LPASVTLTEVSPRDGFQNIEQWIPTETKINIVEGIFRSGVKNIEVT-------SFVSPKA 63 Query: 61 IARQVKNSRVCA---LARCVEKDIDVAAESLKVAEAFR--------IHTFIATSPMHIAT 109 I Q+K++ + A +A D+++ A V A R ++ I+ SP+H Sbjct: 64 IP-QMKDAAIVAEYAVAMAKNTDVNIMALIPNVKGAERALSCGIRKVNYIISASPLHNKK 122 Query: 110 KLRSTLDEVIERAIYMVKRARNYTD-DVE------FSCEDAGRTPIADLARVVEAAINAG 162 + T E E + + +N+ + DV F C G+ P+ D+ ++ AA + G Sbjct: 123 NMNRTPQESFEA---LCELKKNFPEADVTLGVATAFGCPFQGKVPVDDVITLMRAARDIG 179 Query: 163 ATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGA 222 + + DT+G P + + L+E N +++H H+ G+A+ N AA+ G Sbjct: 180 INSFTLCDTIGVANPRQVETL---LHEVKKNFSDIQLALHLHNTHGMALANIYAAMLQGV 236 Query: 223 RQVEGAMNGIG------ERAGNCSLEEVI 245 + E A+ G+G AGN + E+++ Sbjct: 237 DRFESAIGGLGGCPFAPGAAGNAATEDLV 265 >UniRef50_D1PZE3 2-isopropylmalate synthase (Fragment) n=1 Tax=Prevotella bergensis DSM 17361 RepID=D1PZE3_9BACT Length = 264 Score = 65.1 bits (157), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 63/251 (25%), Positives = 113/251 (45%), Gaps = 9/251 (3%) Query: 255 LNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIM 314 L+V T IN ++ S++V + + N+ IVG F +G+H DG K+ + Sbjct: 2 LHVRTNINESQLNMISRVVEDHSGIAVAPNQPIVGENVFTQVAGVHADGDNKDNLYCNEL 61 Query: 315 TPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYD 374 PE G + L SG+A ++ ++E+G + + + +L D+K V D Sbjct: 62 KPERFGRKR-AYALGKNSGKANIEKNLEELGMELTPEQTRMVTQRITELGDRKEFVTQAD 120 Query: 375 LEAL-AFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVY 433 L + + + K + + +L + V + A++K+ + + G+G DA Sbjct: 121 LPFIVSDVLKHNTQEDCVKLLSYMVSTSYGLKPIASIKVEINGKDYMGESTGDGQYDAFV 180 Query: 434 QAINRITEYNV-----ELVKYSLT-AKGHGKDALGQVDIVAN-YNGRRFHGVGLATDIVE 486 +A+ +I + N+ L Y+++ G DAL Q I + +GR GL D E Sbjct: 181 KALRKIYKENLNRTFPRLANYTVSIPPGGHTDALVQTVITWHEESGRMIRTQGLDVDQTE 240 Query: 487 SSAKAMVHVLN 497 S+ KA +LN Sbjct: 241 SAIKATFKMLN 251 >UniRef50_A3JC95 Pyruvate carboxyltransferase n=5 Tax=Gammaproteobacteria RepID=A3JC95_9ALTE Length = 308 Score = 64.7 bits (156), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 68/288 (23%), Positives = 130/288 (45%), Gaps = 33/288 (11%) Query: 13 RDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCA 72 RDG Q+ +LSV+++L + AL ++G+ +E G F S + + + + A Sbjct: 11 RDGLQSQGKTLSVEDRLSLIQALVKVGLKNVEAG-------SFVSPKAVPQMAGTDDLFA 63 Query: 73 L------ARCVEKDIDVAAESLKVAE-AFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 L R ++ L VA A ++ ++ + +R +L + +E + Sbjct: 64 LLPERSAVRYAGLVPNMKGYELAVAAGANVVNVVLSVTETMNQKNIRMSLPQTVEVCTAI 123 Query: 126 VKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE 179 ++R R +V+ F C G A +AR+ + AGA+ I I DT+G P Sbjct: 124 IERGRCEGVEVQAYLAVAFECPFEGLVEPAVVARLAKRLEQAGASKIIIADTIGAANPEH 183 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIG------ 233 +++G+ + + I+S H HD G+A+ N AA+ G R+ + ++ G+G Sbjct: 184 VRRLLNGV---ISEVGSDILSCHFHDTRGIALANITAALDHGIREFDTSIGGLGGCPFSP 240 Query: 234 ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPI 281 GN + E+V++ + + + T IN ++ L Q+ +P+ Sbjct: 241 GATGNVATEDVVLLL----NSMGHDTGINPFDLVPVVCLAEQLTGVPL 284 >UniRef50_B1QUV6 Homocitrate synthase, omega subunit n=2 Tax=Clostridium butyricum RepID=B1QUV6_CLOBU Length = 315 Score = 64.3 bits (155), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 46/175 (26%), Positives = 91/175 (52%), Gaps = 12/175 (6%) Query: 187 LYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIM 246 LYE + ++ + + D + G ++ + G +++ + GI AGN LEE++ Sbjct: 116 LYEVIEKLEDRV-ELSITDKYKCSTGIAVEWIRLGGKKIVTSFAGI---AGNTPLEELLG 171 Query: 247 AIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLK 306 A++ + N++ + + + S+L +I IP K ++G+ F SGIH +G++K Sbjct: 172 ALRY---VENINIRGDLRVFKKISKLYEEITCTSIPPTKPLIGTDIFNVESGIHVNGIIK 228 Query: 307 NRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 N + +E PE +G + ++ + SG ++K + +E+ + EYN + L DA L Sbjct: 229 NSKTFEPYNPEEVG-GERKIIIGKHSGIKSLKIKFEEL---KIEYNSECL-DAIL 278 >UniRef50_P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial n=241 Tax=cellular organisms RepID=HMGCL_HUMAN Length = 325 Score = 63.5 bits (153), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 66/297 (22%), Positives = 129/297 (43%), Gaps = 33/297 (11%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + ++V I + RDG Q + +S K+++ L G+ V+E F S + Sbjct: 29 LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETT-------SFVSPKW 81 Query: 61 IARQVKNSRVC-ALARCVEKDIDVAAESLK------VAEAFRIHTFIATSPMHIATKLRS 113 + + ++ V + + + V +LK A A + F A S + + Sbjct: 82 VPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINC 141 Query: 114 TLDEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTIN 167 +++E +R ++K A++ V C G+ A +A V + + G I+ Sbjct: 142 SIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEIS 201 Query: 168 IPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEG 227 + DT+G P ++S + + VP A ++VH HD G A+ N+L A+ G V+ Sbjct: 202 LGDTIGVGTPGIMKDMLSAVMQEVP---LAALAVHCHDTYGQALANTLMALQMGVSVVDS 258 Query: 228 AMNGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICN 278 ++ G+G +GN + E+++ + + L +HT +N Q++ + Q N Sbjct: 259 SVAGLGGCPYAQGASGNLATEDLVYML----EGLGIHTGVNLQKLLEAGNFICQALN 311 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_A6T4L9 2-isopropylmalate synthase n=327 Tax=Bacteria Re... 701 0.0 UniRef50_B2VDA7 2-isopropylmalate synthase n=4 Tax=Enterobacteri... 688 0.0 UniRef50_P48571 2-isopropylmalate synthase n=3 Tax=Buchnera aphi... 632 e-179 UniRef50_Q3AEQ5 2-isopropylmalate synthase n=42 Tax=Bacteria Rep... 608 e-172 UniRef50_B8DM91 2-isopropylmalate synthase n=31 Tax=Bacteria Rep... 594 e-168 UniRef50_B8J4F8 2-isopropylmalate synthase n=3 Tax=Desulfovibrio... 591 e-167 UniRef50_B7GH19 2-isopropylmalate synthase n=98 Tax=cellular org... 583 e-165 UniRef50_Q7UI51 2-isopropylmalate synthase n=1 Tax=Rhodopirellul... 583 e-165 UniRef50_A4YZ76 2-isopropylmalate synthase n=131 Tax=root RepID=... 582 e-164 UniRef50_Q2IUT4 2-isopropylmalate synthase n=119 Tax=Bacteria Re... 579 e-164 UniRef50_Q2YBW0 2-isopropylmalate synthase n=2 Tax=Bacteria RepI... 574 e-162 UniRef50_A7Z7B8 2-isopropylmalate synthase n=11 Tax=Bacillales R... 574 e-162 UniRef50_A8FFW5 2-isopropylmalate synthase n=224 Tax=Bacilli Rep... 574 e-162 UniRef50_D2M1E9 2-isopropylmalate synthase n=1 Tax=Bacillus cell... 571 e-161 UniRef50_A3PDH0 2-isopropylmalate synthase n=42 Tax=cellular org... 569 e-161 UniRef50_Q72JC9 2-isopropylmalate synthase n=4 Tax=Thermaceae Re... 559 e-157 UniRef50_A6EER4 2-isopropylmalate synthase n=3 Tax=Sphingobacter... 557 e-157 UniRef50_B6YRN0 2-isopropylmalate synthase n=1 Tax=Candidatus Az... 552 e-155 UniRef50_A3DF94 2-isopropylmalate synthase n=3 Tax=Clostridium t... 551 e-155 UniRef50_A6LDN1 2-isopropylmalate synthase n=6 Tax=Bacteria RepI... 549 e-154 UniRef50_B8J824 2-isopropylmalate synthase n=7 Tax=Bacteria RepI... 549 e-154 UniRef50_Q5F8D4 2-isopropylmalate synthase n=73 Tax=cellular org... 548 e-154 UniRef50_Q9C550 2-isopropylmalate synthase 2, chloroplastic n=59... 544 e-153 UniRef50_B3DX88 2-isopropylmalate synthase n=12 Tax=Bacteria Rep... 544 e-153 UniRef50_D0MYD7 2-isopropylmalate synthase n=2 Tax=Phytophthora ... 536 e-151 UniRef50_C7JAV8 2-isopropylmalate synthase n=8 Tax=Acetobacter p... 536 e-151 UniRef50_UPI0001C31767 2-isopropylmalate synthase n=1 Tax=Conexi... 536 e-150 UniRef50_O27525 2-isopropylmalate synthase 2 n=22 Tax=Archaea Re... 531 e-149 UniRef50_C0Z635 Probable 2-isopropylmalate synthase n=1 Tax=Brev... 525 e-147 UniRef50_A2C859 2-isopropylmalate synthase n=16 Tax=Bacteria Rep... 524 e-147 UniRef50_B4SI67 2-isopropylmalate synthase n=45 Tax=Xanthomonada... 524 e-147 UniRef50_Q58787 (R)-citramalate synthase n=5 Tax=Methanococcales... 522 e-146 UniRef50_Q9LPR4 2-isopropylmalate synthase 1, chloroplastic n=39... 520 e-146 UniRef50_Q2S0M7 2-isopropylmalate synthase n=3 Tax=Bacteria RepI... 519 e-145 UniRef50_A9KRN2 2-isopropylmalate synthase n=8 Tax=Bacteria RepI... 514 e-144 UniRef50_D2RHN2 Isopropylmalate/citramalate/homocitratesynthase ... 511 e-143 UniRef50_Q1ARE2 2-isopropylmalate synthase n=1 Tax=Rubrobacter x... 509 e-142 UniRef50_UPI0001C41E20 2-isopropylmalate synthase LeuA n=1 Tax=M... 504 e-141 UniRef50_O26819 (R)-citramalate synthase n=20 Tax=Archaea RepID=... 504 e-141 UniRef50_P58968 2-isopropylmalate synthase 2 n=19 Tax=Archaea Re... 504 e-141 UniRef50_UPI0001C42034 citramalate synthase CimA n=1 Tax=Methano... 500 e-140 UniRef50_C6CVJ5 2-isopropylmalate synthase n=2 Tax=Bacillales Re... 498 e-139 UniRef50_A6VFV4 Isopropylmalate/citramalate/homocitrate synthase... 491 e-137 UniRef50_A8TGZ1 Isopropylmalate/citramalate/homocitrate synthase... 487 e-136 UniRef50_A8V4T9 2-isopropylmalate synthase (Fragment) n=2 Tax=ce... 485 e-135 UniRef50_C5SF21 Pyruvate carboxyltransferase n=1 Tax=Asticcacaul... 473 e-132 UniRef50_Q0AT07 2-isopropylmalate synthase n=3 Tax=Alphaproteoba... 472 e-131 UniRef50_D2RVT7 Pyruvate carboxyltransferase n=1 Tax=Haloterrige... 452 e-125 UniRef50_Q18KM5 2-isopropylmalate synthase n=9 Tax=Euryarchaeota... 447 e-124 UniRef50_O66682 Uncharacterized AIPM/Hcit synthase family transf... 444 e-123 UniRef50_D2RHQ3 Isopropylmalate/citramalate/homocitratesynthase ... 444 e-123 UniRef50_C6PDK4 Pyruvate carboxyltransferase n=1 Tax=Thermoanaer... 436 e-120 UniRef50_Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic ... 436 e-120 UniRef50_Q2RGA1 2-isopropylmalate synthase n=5 Tax=Clostridia Re... 432 e-119 UniRef50_A8AB61 2-isopropylmalate synthase n=25 Tax=Archaea RepI... 425 e-117 UniRef50_D2MJY3 2-isopropylmalate synthase n=1 Tax=Candidatus Po... 423 e-116 UniRef50_C3NF24 2-isopropylmalate synthase/homocitrate synthase ... 413 e-114 UniRef50_A8HXS9 Isopropylmalate synthase (Fragment) n=1 Tax=Chla... 407 e-112 UniRef50_B1MVR2 2-isopropylmalate synthase n=1 Tax=Leuconostoc c... 406 e-112 UniRef50_Q57926 2-isopropylmalate synthase 1 n=16 Tax=Euryarchae... 405 e-111 UniRef50_D1PA75 (R)-citramalate synthase n=1 Tax=Prevotella copr... 404 e-111 UniRef50_P74269 Uncharacterized AIPM/Hcit synthase family transf... 402 e-110 UniRef50_C6VV54 Pyruvate carboxyltransferase n=32 Tax=Bacteria R... 400 e-110 UniRef50_B9KY22 2-isopropylmalate synthase/homocitrate synthase ... 395 e-108 UniRef50_Q02CM5 2-isopropylmalate synthase n=1 Tax=Candidatus So... 395 e-108 UniRef50_A6C4F8 2-isopropylmalate synthase n=1 Tax=Planctomyces ... 394 e-108 UniRef50_Q3M862 2-isopropylmalate synthase n=4 Tax=Bacteria RepI... 394 e-108 UniRef50_A8ZTR1 2-isopropylmalate synthase/homocitrate synthase ... 393 e-108 UniRef50_P06208 2-isopropylmalate synthase n=109 Tax=cellular or... 392 e-107 UniRef50_Q12166 2-isopropylmalate synthase 2, mitochondrial n=8 ... 390 e-107 UniRef50_D1AJT6 2-isopropylmalate synthase/homocitrate synthase ... 390 e-107 UniRef50_D2QST1 Pyruvate carboxyltransferase n=1 Tax=Spirosoma l... 390 e-107 UniRef50_B3TC58 Putative HMGL-like protein n=1 Tax=uncultured ma... 386 e-105 UniRef50_Q04TA5 2-isopropylmalate/homocitrate synthase n=14 Tax=... 385 e-105 UniRef50_C1ZKW9 Isopropylmalate/homocitrate/citramalate synthase... 385 e-105 UniRef50_A8L551 2-isopropylmalate synthase n=38 Tax=Bacteria Rep... 385 e-105 UniRef50_UPI000038E0F9 2-isopropylmalate synthase n=1 Tax=Ferrop... 384 e-105 UniRef50_Q6L0K4 2-isopropylmalate synthase n=1 Tax=Picrophilus t... 383 e-105 UniRef50_C8WRC1 2-isopropylmalate synthase n=14 Tax=Bacteria Rep... 383 e-104 UniRef50_A5VPL4 2-isopropylmalate synthase/homocitrate synthase ... 381 e-104 UniRef50_Q97MC5 2-isopropylmalate synthase n=50 Tax=Bacteria Rep... 378 e-103 UniRef50_A4A2P3 2-isopropylmalate synthase n=1 Tax=Blastopirellu... 378 e-103 UniRef50_Q3A2Q7 Homocitrate synthase 1 n=18 Tax=Bacteria RepID=Q... 375 e-102 UniRef50_C9RKZ6 Pyruvate carboxyltransferase n=1 Tax=Fibrobacter... 375 e-102 UniRef50_B3PEP5 2-isopropylmalate synthase n=90 Tax=Bacteria Rep... 375 e-102 UniRef50_B1L4G2 Pyruvate carboxyltransferase n=1 Tax=Candidatus ... 375 e-102 UniRef50_Q7VH30 2-isopropylmalate synthase n=16 Tax=Bacteria Rep... 373 e-101 UniRef50_P58967 2-isopropylmalate synthase 1 n=9 Tax=Euryarchaeo... 372 e-101 UniRef50_A6TTX4 Pyruvate carboxyltransferase n=1 Tax=Alkaliphilu... 371 e-101 UniRef50_B2UP78 2-isopropylmalate synthase/homocitrate synthase ... 370 e-101 UniRef50_Q2JTM1 Homocitrate synthase NifV n=7 Tax=Cyanobacteria ... 370 e-100 UniRef50_D2RXB9 Pyruvate carboxyltransferase n=3 Tax=Halobacteri... 369 e-100 UniRef50_A6LPH9 Homocitrate synthase n=10 Tax=Clostridia RepID=A... 369 e-100 UniRef50_O86511 Uncharacterized AIPM/Hcit synthase family transf... 369 e-100 UniRef50_C9RN88 2-isopropylmalate synthase/homocitrate synthase ... 368 e-100 UniRef50_A1KBD3 2-isopropylmalate synthase n=14 Tax=Bacteria Rep... 367 e-100 UniRef50_B3DXX9 Homocitrate/citramalate synthase n=1 Tax=Methyla... 367 e-100 UniRef50_B2AHM5 2-isopropylmalate synthase n=69 Tax=cellular org... 366 e-100 UniRef50_A0LSS5 2-isopropylmalate synthase n=12 Tax=Bacteria Rep... 365 2e-99 UniRef50_C4XS62 Pyruvate carboxyltransferase n=1 Tax=Desulfovibr... 365 2e-99 UniRef50_Q8KTR5 Alpha-isopropylmalate synthase n=14 Tax=Candidat... 364 5e-99 UniRef50_Q44290 Homocitrate synthase 1 n=45 Tax=Bacteria RepID=N... 363 1e-98 UniRef50_D2L197 Pyruvate carboxyltransferase n=1 Tax=Desulfovibr... 362 2e-98 UniRef50_Q2FKU8 2-isopropylmalate synthase n=3 Tax=Methanomicrob... 362 2e-98 UniRef50_C3MPM7 2-isopropylmalate synthase n=19 Tax=Thermoprotei... 361 5e-98 UniRef50_A4QAP0 2-isopropylmalate synthase n=225 Tax=cellular or... 360 6e-98 UniRef50_Q0EZI5 2-isopropylmalate synthase n=1 Tax=Mariprofundus... 360 7e-98 UniRef50_D1N7Y9 Pyruvate carboxyltransferase n=2 Tax=Victivallis... 358 4e-97 UniRef50_B8FYI5 Pyruvate carboxyltransferase n=5 Tax=Bacteria Re... 357 7e-97 UniRef50_C5S831 2-isopropylmalate synthase n=20 Tax=Bacteria Rep... 357 7e-97 UniRef50_Q6KZ01 2-isopropylmalate synthase n=1 Tax=Picrophilus t... 353 8e-96 UniRef50_C8WE03 Homocitrate synthase n=3 Tax=Zymomonas mobilis R... 353 1e-95 UniRef50_B7GT76 2-isopropylmalate synthase n=19 Tax=Bifidobacter... 351 4e-95 UniRef50_C1SID8 Isopropylmalate/homocitrate/citramalate synthase... 350 7e-95 UniRef50_B4S9H2 Pyruvate carboxyltransferase n=13 Tax=Bacteria R... 349 1e-94 UniRef50_B9LUZ7 Pyruvate carboxyltransferase n=1 Tax=Halorubrum ... 349 2e-94 UniRef50_B8FAB3 Pyruvate carboxyltransferase n=1 Tax=Desulfatiba... 349 2e-94 UniRef50_B0CSN8 Predicted protein (Fragment) n=11 Tax=cellular o... 348 3e-94 UniRef50_B0TAQ1 Homocitrate synthase, nifv n=4 Tax=Clostridiales... 347 6e-94 UniRef50_B8I2I3 Pyruvate carboxyltransferase n=1 Tax=Clostridium... 344 4e-93 UniRef50_Q5KCL7 2-isopropylmalate synthase, putative n=1 Tax=Fil... 343 1e-92 UniRef50_UPI000038E0D5 2-isopropylmalate synthase n=1 Tax=Ferrop... 339 2e-91 UniRef50_D1XS06 2-isopropylmalate synthase n=1 Tax=Streptomyces ... 339 2e-91 UniRef50_Q56216 2-isopropylmalate synthase (Fragment) n=1 Tax=Th... 336 9e-91 UniRef50_Q0ZQ46 FrbC n=3 Tax=Bacteria RepID=Q0ZQ46_9ACTO 336 2e-90 UniRef50_Q1QBL0 2-isopropylmalate synthase n=5 Tax=Bacteria RepI... 334 4e-90 UniRef50_A6FCI3 2-isopropylmalate synthase n=1 Tax=Moritella sp.... 333 1e-89 UniRef50_A6DIP7 2-isopropylmalate synthase n=1 Tax=Lentisphaera ... 333 1e-89 UniRef50_P54610 Homocitrate synthase n=6 Tax=Frankia RepID=NIFV_... 332 2e-89 UniRef50_Q9V1J1 2-isopropylmalate synthase 2 n=5 Tax=Thermococca... 330 6e-89 UniRef50_A9A1L0 Pyruvate carboxyltransferase n=6 Tax=Thaumarchae... 329 2e-88 UniRef50_C6HVD7 2-isopropylmalate synthase n=1 Tax=Leptospirillu... 328 2e-88 UniRef50_A7IBL6 Homocitrate synthase n=19 Tax=Proteobacteria Rep... 328 4e-88 UniRef50_D2LHQ1 Homocitrate synthase n=1 Tax=Rhodomicrobium vann... 326 1e-87 UniRef50_B6YRB4 Homocitrate synthase n=1 Tax=Candidatus Azobacte... 325 2e-87 UniRef50_Q52070 Homocitrate synthase n=9 Tax=Gammaproteobacteria... 325 2e-87 UniRef50_Q12122 Homocitrate synthase, mitochondrial n=109 Tax=ce... 324 5e-87 UniRef50_C5QA64 2-isopropylmalate synthase n=1 Tax=Staphylococcu... 321 3e-86 UniRef50_C7N750 Isopropylmalate/homocitrate/citramalate synthase... 321 4e-86 UniRef50_Q7M8U7 HOMOCITRATE SYTHASE 1 n=1 Tax=Wolinella succinog... 321 4e-86 UniRef50_B7G5N8 2-isopropylmalate synthase n=2 Tax=Bacillariophy... 320 8e-86 UniRef50_B5JMT2 HMGL-like domain protein n=1 Tax=Verrucomicrobia... 319 2e-85 UniRef50_C0W2B6 Alpha-isopropylmalate/homocitrate synthase famil... 318 4e-85 UniRef50_C1FHL1 2-isopropylmalate synthase n=2 Tax=cellular orga... 313 1e-83 UniRef50_Q01181 Homocitrate synthase n=27 Tax=Proteobacteria Rep... 311 3e-83 UniRef50_A8F3U8 2-isopropylmalate synthase n=1 Tax=Thermotoga le... 311 4e-83 UniRef50_D0LNR8 Pyruvate carboxyltransferase n=1 Tax=Haliangium ... 308 4e-82 UniRef50_A9VAW1 Predicted protein n=1 Tax=Monosiga brevicollis R... 308 5e-82 UniRef50_A3JSY7 Putative uncharacterized protein n=2 Tax=Bacteri... 307 8e-82 UniRef50_Q07179 Homocitrate synthase n=3 Tax=Rhodobacter RepID=N... 307 9e-82 UniRef50_C1AUX2 2-isopropylmalate synthase n=8 Tax=Bacteria RepI... 306 1e-81 UniRef50_B0TW82 2-isopropylmalate synthase n=17 Tax=Francisella ... 303 9e-81 UniRef50_B8FRV4 2-isopropylmalate synthase n=2 Tax=Desulfitobact... 299 2e-79 UniRef50_A2QSZ0 Contig An09c0020, complete genome n=1 Tax=Asperg... 296 1e-78 UniRef50_Q1IYY1 Homocitrate synthase n=1 Tax=Deinococcus geother... 296 2e-78 UniRef50_Q04QM8 Isopropylmalate/homocitrate/citramalatesynthase ... 292 2e-77 UniRef50_Q0W3Q1 2-isopropylmalate synthase n=8 Tax=Archaea RepID... 292 3e-77 UniRef50_C7LNR6 Pyruvate carboxyltransferase n=1 Tax=Desulfomicr... 291 6e-77 UniRef50_C9YAE2 Putative uncharacterized protein n=1 Tax=Curviba... 290 8e-77 UniRef50_C6BX35 Pyruvate carboxyltransferase n=1 Tax=Desulfovibr... 290 9e-77 UniRef50_Q10Y65 2-isopropylmalate synthase n=1 Tax=Trichodesmium... 288 3e-76 UniRef50_C0AC93 Trans-homoaconitate synthase n=2 Tax=Opitutaceae... 285 3e-75 UniRef50_D1U2X4 Pyruvate carboxyltransferase n=1 Tax=Desulfovibr... 283 1e-74 UniRef50_B0PEC7 Putative uncharacterized protein n=1 Tax=Anaerot... 282 2e-74 UniRef50_C6A4Y6 2-isopropylmalate synthase 1 n=1 Tax=Thermococcu... 278 4e-73 UniRef50_B9YLN5 2-isopropylmalate synthase n=2 Tax=Nostocaceae R... 277 5e-73 UniRef50_C8W3E1 Pyruvate carboxyltransferase n=1 Tax=Desulfotoma... 277 9e-73 UniRef50_Q2GMU3 Putative uncharacterized protein n=1 Tax=Chaetom... 276 2e-72 UniRef50_P70728 Homocitrate synthase n=1 Tax=Azospirillum brasil... 275 2e-72 UniRef50_C0Z7H0 Alpha-isopropylmalate/homocitrate synthase famil... 273 1e-71 UniRef50_Q46A98 Homocitrate synthase n=2 Tax=Methanosarcina RepI... 271 7e-71 UniRef50_C0GSN3 Pyruvate carboxyltransferase n=1 Tax=Desulfonatr... 270 1e-70 UniRef50_C1XGU5 Isopropylmalate/homocitrate/citramalate synthase... 269 1e-70 UniRef50_A8A943 Pyruvate carboxyltransferase n=1 Tax=Ignicoccus ... 268 3e-70 UniRef50_Q2FZS6 2-isopropylmalate synthase, putative n=51 Tax=St... 268 4e-70 UniRef50_B1L5J0 2-isopropylmalate synthase n=1 Tax=Candidatus Ko... 267 9e-70 UniRef50_C9K7B8 Similar to 2-isopropylmalate synthase n=1 Tax=Al... 267 1e-69 UniRef50_A6FZR1 Homocitrate synthase n=1 Tax=Plesiocystis pacifi... 266 2e-69 UniRef50_Q3IV11 Isopropylmalate/homocitrate synthase n=1 Tax=Rho... 266 2e-69 UniRef50_B8DR73 Pyruvate carboxyltransferase n=3 Tax=Desulfovibr... 266 2e-69 UniRef50_B8J227 Pyruvate carboxyltransferase n=2 Tax=Desulfovibr... 264 4e-69 UniRef50_D2JWV4 Putative homocitrate synthase n=1 Tax=Filobasidi... 264 5e-69 UniRef50_C5AK37 Isopropylmalate/homocitrate/citramalate synthase... 263 2e-68 UniRef50_A8TLL5 Homocitrate synthase n=1 Tax=alpha proteobacteri... 259 2e-67 UniRef50_A9HXK1 2-isopropylmalate synthase (Fragment) n=1 Tax=Ro... 258 4e-67 UniRef50_Q7X1M2 Homocitrate synthase (Fragment) n=1 Tax=Leptospi... 258 4e-67 UniRef50_Q1DCT2 2-isopropylmalate synthase/homocitrate synthase ... 254 4e-66 UniRef50_C7GH85 2-isopropylmalate synthase n=3 Tax=Roseburia Rep... 254 9e-66 UniRef50_D1J0N9 Whole genome shotgun sequence of line PN40024, s... 252 2e-65 UniRef50_B4B8D2 Pyruvate carboxyltransferase n=1 Tax=Cyanothece ... 252 2e-65 UniRef50_B1I1Z4 Pyruvate carboxyltransferase n=1 Tax=Candidatus ... 252 3e-65 UniRef50_B2KBD6 Pyruvate carboxyltransferase n=7 Tax=Bacteria Re... 250 7e-65 UniRef50_B5HTY3 2-isopropylmalate synthase n=1 Tax=Streptomyces ... 250 8e-65 UniRef50_C7IGD9 Homocitrate synthase n=1 Tax=Clostridium papyros... 249 2e-64 UniRef50_A4QUQ8 Putative uncharacterized protein n=1 Tax=Magnapo... 246 1e-63 UniRef50_A5N6T4 2-isopropylmalate synthase-related protein n=2 T... 246 1e-63 UniRef50_Q1NS12 Pyruvate carboxyltransferase n=2 Tax=delta prote... 246 1e-63 UniRef50_Q2LTE1 Isopropylmalate/homocitrate/citramalate synthase... 246 2e-63 UniRef50_A8MBK1 Pyruvate carboxyltransferase n=1 Tax=Caldivirga ... 243 1e-62 UniRef50_Q72WS3 Homocitrate synthase n=2 Tax=Desulfovibrio vulga... 240 1e-61 UniRef50_A0YSY8 2-isopropylmalate synthase n=1 Tax=Lyngbya sp. P... 240 1e-61 UniRef50_C7YY11 Putative uncharacterized protein n=2 Tax=Nectria... 240 1e-61 UniRef50_D0LGL9 2-isopropylmalate synthase n=3 Tax=Nannocystinea... 238 5e-61 UniRef50_B1QUV5 Homocitrate synthase 1 n=2 Tax=Clostridium butyr... 237 9e-61 UniRef50_UPI0001B425AC 2-isopropylmalate synthase n=1 Tax=Lister... 235 2e-60 UniRef50_C1MYB9 2-isopropylmalate synthase n=1 Tax=Micromonas pu... 230 8e-59 UniRef50_A8MB07 2-isopropylmalate synthase n=1 Tax=Caldivirga ma... 228 3e-58 UniRef50_Q6T1C1 2-isopropylmalate synthase (Fragment) n=1 Tax=Xe... 228 4e-58 UniRef50_Q00853 Homocitrate synthase subunit alpha n=8 Tax=Clost... 227 9e-58 UniRef50_B4WHZ2 HMGL-like domain protein n=1 Tax=Synechococcus s... 226 2e-57 UniRef50_Q97A78 2-isopropylmalate/homocitrate synthetase n=1 Tax... 225 2e-57 UniRef50_C8QZK2 2-isopropylmalate synthase n=1 Tax=Desulfurivibr... 219 2e-55 UniRef50_B2J8P8 Pyruvate carboxyltransferase n=2 Tax=Nostocaceae... 215 3e-54 UniRef50_Q1IW44 HMGL-like domain protein n=4 Tax=Bacteria RepID=... 207 1e-51 UniRef50_P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial n... 203 2e-50 UniRef50_D1PZE3 2-isopropylmalate synthase (Fragment) n=1 Tax=Pr... 202 2e-50 UniRef50_B4VB43 2-isopropylmalate synthase n=1 Tax=Streptomyces ... 202 4e-50 UniRef50_A6CMV0 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillus... 201 6e-50 UniRef50_B9K380 Isopropylmalate/homocitrate/citramalate synthase... 200 1e-49 UniRef50_C0GGI7 Pyruvate carboxyltransferase n=1 Tax=Dethiobacte... 198 3e-49 UniRef50_UPI000038E183 2-isopropylmalate synthase n=1 Tax=Ferrop... 196 2e-48 UniRef50_Q2RAU5 Hydroxymethylglutaryl-CoA lyase, mitochondrial, ... 194 7e-48 UniRef50_C0WB33 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria... 193 2e-47 UniRef50_B0SA13 2-isopropylmalate synthase n=5 Tax=Leptospira Re... 193 2e-47 UniRef50_O34873 Hydroxymethylglutaryl-CoA lyase yngG n=13 Tax=Ba... 192 2e-47 UniRef50_D0Z8X0 Putative hydroxymethylglutaryl-CoA lyase n=1 Tax... 192 3e-47 UniRef50_A8WG57 Probable 3-hydroxymethyl-3-methylglutaryl-CoA ly... 192 3e-47 UniRef50_Q8TB92 Probable 3-hydroxymethyl-3-methylglutaryl-CoA ly... 192 3e-47 UniRef50_P35915 Hydroxymethylglutaryl-CoA lyase n=108 Tax=cellul... 189 2e-46 UniRef50_C8WQC0 Pyruvate carboxyltransferase n=2 Tax=Alicyclobac... 189 2e-46 UniRef50_A8MEN7 Pyruvate carboxyltransferase n=1 Tax=Alkaliphilu... 189 2e-46 UniRef50_A8FDY7 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacillus... 187 9e-46 UniRef50_Q5WKL8 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillac... 187 1e-45 UniRef50_A9F2G5 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacteria... 186 2e-45 UniRef50_C6JJQ3 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria... 186 2e-45 UniRef50_C8SJR8 Homocitrate synthase n=1 Tax=Mesorhizobium oppor... 186 2e-45 UniRef50_D1WUS8 2-isopropylmalate synthase n=2 Tax=Streptomyces ... 185 2e-45 UniRef50_D2VQL9 Predicted protein n=1 Tax=Naegleria gruberi RepI... 185 4e-45 UniRef50_D1TMW3 Hydroxymethylglutaryl-CoA lyase n=1 Tax=Burkhold... 184 6e-45 UniRef50_A3JC95 Pyruvate carboxyltransferase n=5 Tax=Gammaproteo... 183 1e-44 UniRef50_C1BAX9 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Rhodococ... 183 1e-44 UniRef50_A9FUN7 Putative 2-isopropylmalate synthase n=1 Tax=Sora... 182 3e-44 UniRef50_B4BIN3 Pyruvate carboxyltransferase n=1 Tax=Geobacillus... 182 4e-44 UniRef50_C7MUV0 Hydroxymethylglutaryl-CoA lyase n=5 Tax=cellular... 182 4e-44 UniRef50_Q15RQ1 Hydroxymethylglutaryl-CoA lyase n=89 Tax=Bacteri... 181 5e-44 UniRef50_D0MGG7 Pyruvate carboxyltransferase n=1 Tax=Rhodothermu... 181 6e-44 Sequences not found previously or not previously below threshold: UniRef50_O81027 Hydroxymethylglutaryl-CoA lyase, mitochondrial n... 187 7e-46 UniRef50_UPI00015B4E2A PREDICTED: similar to hydroxymethylglutar... 185 4e-45 UniRef50_Q28KR2 Hydroxymethylglutaryl-CoA lyase n=5 Tax=Alphapro... 184 7e-45 UniRef50_A4X0W1 Pyruvate carboxyltransferase n=3 Tax=Actinomycet... 182 3e-44 >UniRef50_A6T4L9 2-isopropylmalate synthase n=327 Tax=Bacteria RepID=LEU1_KLEP7 Length = 523 Score = 701 bits (1810), Expect = 0.0, Method: Composition-based stats. Identities = 486/523 (92%), Positives = 512/523 (97%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT Sbjct: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 IAR +KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE Sbjct: 61 IARTIKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE+ Sbjct: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEY 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 A IISGLY+RVPNIDKAIISVHTHDDLG+AVGN+LAAVHAGARQVEGAMNGIGERAGNC+ Sbjct: 181 ANIISGLYDRVPNIDKAIISVHTHDDLGIAVGNALAAVHAGARQVEGAMNGIGERAGNCA 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEVIMAIKVRKDI+NVHT INH EIWRTSQ VSQICNMPIPANKAIVG+GAFAHSSGIH Sbjct: 241 LEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGTGAFAHSSGIH 300 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 QDGVLKNRENYEIMTPESIGLNQ+QLNLTSRSGRAAVKHRM+EMGY+ES+YNLD+LYDAF Sbjct: 301 QDGVLKNRENYEIMTPESIGLNQVQLNLTSRSGRAAVKHRMEEMGYQESDYNLDHLYDAF 360 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 LKLADKKGQVFDYDLEALAFI KQQEEPEHFRLDYF+VQSGS+DIATA++KL CG+E+K Sbjct: 361 LKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFNVQSGSSDIATASIKLVCGDEIKT 420 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 EAANGNGPVDA+YQAINR+T+YN+ELVKY L+AKGHGKDALGQVDIV +YNGRRFHGVGL Sbjct: 421 EAANGNGPVDAIYQAINRVTDYNIELVKYGLSAKGHGKDALGQVDIVVDYNGRRFHGVGL 480 Query: 481 ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV 523 ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQ+ ENNKETV Sbjct: 481 ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV 523 >UniRef50_B2VDA7 2-isopropylmalate synthase n=4 Tax=Enterobacteriaceae RepID=LEU1_ERWT9 Length = 522 Score = 688 bits (1777), Expect = 0.0, Method: Composition-based stats. Identities = 431/523 (82%), Positives = 477/523 (91%), Gaps = 1/523 (0%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT Sbjct: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 IARQ+KNSRVC LARCVEKDID A E+L+VA+A+RIHTF+ATSPMHIATKLRSTL EVIE Sbjct: 61 IARQIKNSRVCGLARCVEKDIDAAYEALRVADAYRIHTFLATSPMHIATKLRSTLPEVIE 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 RA+ M++RARNYTDDVEFSCED GRTPI DL RVVEAAINAGATTINIPDTVGYT+P+E+ Sbjct: 121 RAVKMIRRARNYTDDVEFSCEDGGRTPIDDLCRVVEAAINAGATTINIPDTVGYTLPYEY 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 A I S L RVPNIDKAI+SVHTHDDLG+AVGN+LAAV+AGARQ+EGAMNG+GERAGNC+ Sbjct: 181 ANIFSALRARVPNIDKAILSVHTHDDLGMAVGNALAAVNAGARQIEGAMNGLGERAGNCA 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEE IMAIK R ++NVHT INHQEI+RT Q VS+ICNMPIPA+KAI+GS AFAHSSGIH Sbjct: 241 LEETIMAIKTRGQLMNVHTRINHQEIYRTCQTVSKICNMPIPAHKAIIGSNAFAHSSGIH 300 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 QDGVLKNRENYEI+TPESIGL Q+QLNLTSRSGRAAVKHRM+EMGY E+EYN+D LYDAF Sbjct: 301 QDGVLKNRENYEILTPESIGLKQVQLNLTSRSGRAAVKHRMEEMGYGETEYNMDRLYDAF 360 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 LADKKGQVFDYDLEALAFI +Q EEPE+FRLD F+VQSGS+ IATA V+L CG+E K Sbjct: 361 KALADKKGQVFDYDLEALAFINQQSEEPEYFRLDTFNVQSGSSVIATATVQLRCGDEQKT 420 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 EAA GNGPVDAVYQAINR+TE++ ELV Y LTAKGHGKDALGQVDIV YNGR+FHGVGL Sbjct: 421 EAATGNGPVDAVYQAINRLTEFDAELVSYQLTAKGHGKDALGQVDIVVQYNGRKFHGVGL 480 Query: 481 ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV 523 ATDIVESSAKAMV+ LN IWRA +VE+ELQRK+Q ++ KETV Sbjct: 481 ATDIVESSAKAMVNALNTIWRARQVEQELQRKSQ-VKDQKETV 522 >UniRef50_P48571 2-isopropylmalate synthase n=3 Tax=Buchnera aphidicola RepID=LEU1_BUCRP Length = 518 Score = 632 bits (1631), Expect = e-179, Method: Composition-based stats. Identities = 350/508 (68%), Positives = 431/508 (84%), Gaps = 1/508 (0%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+ QVIIFDTTLRDGEQALQASLSVK+KLQIAL+LE G+D++EVGFP+SSPGDF+SVQT Sbjct: 1 MNSQVIIFDTTLRDGEQALQASLSVKQKLQIALSLENTGIDIIEVGFPISSPGDFKSVQT 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I++ +KNSR+C+LARC++KDID AAE++ + AFRIH F+ATS +H+ +KL+ D++I+ Sbjct: 61 ISKNIKNSRICSLARCLDKDIDAAAEAMHSSNAFRIHIFLATSILHMESKLKKNFDQIID 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 AI VKRA YTDDVEFSCEDA RT + +L R+VE INAG TINIPDTVGYT+P E Sbjct: 121 MAITSVKRALRYTDDVEFSCEDASRTTMDNLCRIVEKLINAGVKTINIPDTVGYTVPNEL 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 + II L++RVPNIDK+IISVH H+DLG+AVGNS++A+ AGARQ+EG +NGIGERAGN + Sbjct: 181 SSIIHNLFQRVPNIDKSIISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTA 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEVI+AIKVR+D+L V T I H+EI+RTSQ++SQICN+PIP NKAIVGS AFAHSSGIH Sbjct: 241 LEEVIIAIKVREDVLGVSTKIKHKEIYRTSQIISQICNLPIPPNKAIVGSNAFAHSSGIH 300 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 QDGVLKNR+NYEIM P SIGL +++LNLTSRSGRAAVKH M EMGY+E +Y +D LY +F Sbjct: 301 QDGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKHYMTEMGYRECDYKIDELYASF 360 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 LKLADKKGQVFDYDLEALAFI +QQEE EHF L +FSVQS SN ++TA+VKL CG++ Sbjct: 361 LKLADKKGQVFDYDLEALAFINQQQEELEHFSLSFFSVQSISNGLSTASVKLLCGKKTFI 420 Query: 421 EAA-NGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVG 479 E+A NGP+DA+YQA+NRIT + + L KY L AKG GKDALGQVDI+ + R+FHG+G Sbjct: 421 ESATTSNGPIDAIYQALNRITHFPIILQKYQLIAKGKGKDALGQVDILVEHKKRKFHGMG 480 Query: 480 LATDIVESSAKAMVHVLNNIWRAAEVEK 507 LATDI+ESSA+AMV+VLNNIW+A +V + Sbjct: 481 LATDIIESSAQAMVNVLNNIWKANQVNE 508 >UniRef50_Q3AEQ5 2-isopropylmalate synthase n=42 Tax=Bacteria RepID=LEU1_CARHZ Length = 509 Score = 608 bits (1567), Expect = e-172, Method: Composition-based stats. Identities = 267/509 (52%), Positives = 354/509 (69%), Gaps = 2/509 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 ++V IFDTTLRDGEQ+ SL+ EKLQIA L+++GVDV+E GFP++SPGD E+V IA Sbjct: 2 ERVRIFDTTLRDGEQSPGVSLNAMEKLQIARQLQKLGVDVIEAGFPITSPGDKEAVSLIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 R+VK V ALAR DI+ A +++K AE+ RIHTFIATS +H+ KL+ + V+ERA Sbjct: 62 REVKGVVVAALARASALDIETAWDAIKDAESPRIHTFIATSDIHLKYKLKMDRETVVERA 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + VK A+ +T DVEFS EDA R+ + L RVVEAA+ AGATTINIPDTVGY P EF Sbjct: 122 VAAVKLAKKFTADVEFSAEDASRSDLDFLCRVVEAAVKAGATTINIPDTVGYAEPEEFGE 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I + E+VP +D+A++SVH HDDLGLAV NSLAA+ GARQVE +NGIGERAGNCSLE Sbjct: 182 FICKILEKVPVMDRAVLSVHCHDDLGLAVANSLAAIKNGARQVECTINGIGERAGNCSLE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E++MA+ RKD+L +T I +EI+RTS+LVS + MP+ NKAIVG AF+H SGIHQD Sbjct: 242 EIVMALYTRKDVLPFYTGIKTEEIYRTSKLVSNLTGMPVQPNKAIVGKNAFSHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 GVLK R YEIM P +G+ + +L L SGR A+K R+ E+GY+ +E L+ + F Sbjct: 302 GVLKERTTYEIMNPRLVGIPESRLVLGKHSGRHALKERLLELGYELTEEQLNEAFVKFKA 361 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEA 422 LADKK +V D DLEA+ + ++ PE + LDYF + +GS I TA V L E +A Sbjct: 362 LADKKKEVTDQDLEAMM-EEEIRKVPETYTLDYFHISTGSTIIPTATVGLIKEGEKLEDA 420 Query: 423 ANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYN-GRRFHGVGLA 481 A G+GPVDA+Y+AIN+IT L +YS+ A G+DALG+V + G+ G G++ Sbjct: 421 ATGDGPVDAIYKAINKITGLTPVLEQYSINAVTSGEDALGEVVVKLKNGLGKIVTGRGVS 480 Query: 482 TDIVESSAKAMVHVLNNIWRAAEVEKELQ 510 TDI+E+SAKA ++ +N + + + E Q Sbjct: 481 TDILEASAKAYLNGINKLLFDYQAKGEKQ 509 >UniRef50_B8DM91 2-isopropylmalate synthase n=31 Tax=Bacteria RepID=LEU1_DESVM Length = 514 Score = 594 bits (1531), Expect = e-168, Method: Composition-based stats. Identities = 253/499 (50%), Positives = 332/499 (66%), Gaps = 2/499 (0%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 S ++ IFDTTLRDGEQ+ A+++++EK+++A LE +GVD+ME GFP SS GDFE+VQ I Sbjct: 5 SGRIRIFDTTLRDGEQSPGATMNLQEKIRLARQLETLGVDIMEAGFPASSQGDFEAVQAI 64 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 AR VK V L R + DID A E++KVAE RIHTF+ATSP+H+ KLR D+V+E Sbjct: 65 ARAVKGVEVAGLCRAMPADIDRAWEAVKVAENPRIHTFLATSPVHMQYKLRKEPDQVVEM 124 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 A+ V+ A YT +VEFS EDA R+ L RV EA INAGATTIN+PDTVGY P EF Sbjct: 125 AVAAVRHAAKYTSNVEFSAEDASRSNPDFLVRVFEAVINAGATTINVPDTVGYAQPEEFG 184 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 +I + E PN KA+ SVH H+DLG+ V N+LAA+ AGARQ E ++GIGERAGN SL Sbjct: 185 RLIRYVIENTPNSHKAVFSVHCHNDLGMGVANTLAALKAGARQAEVTISGIGERAGNASL 244 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EE++MA+ R+D + + ++++ T +L+S I PIP NKAIVG+ AFAH SGIHQ Sbjct: 245 EEIVMALHTRRDFYQLDCGVVTEQLFPTCRLLSMIIGQPIPPNKAIVGANAFAHESGIHQ 304 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 DG+LKNRE YEIMTPESIG + L + SGR AVK+++DE+GY+ E L +++A Sbjct: 305 DGMLKNRETYEIMTPESIGKTKTDLVIGKHSGRNAVKNKLDELGYRLEEAQLVTVFEAVK 364 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQ-SGSNDIATAAVKLACGEEVKA 420 KLADKK Q++D D+EAL + P+ +RL SVQ S + TAAV + EVK Sbjct: 365 KLADKKKQIYDEDIEALVLEEVYR-LPDLYRLVNLSVQCSDTGMPPTAAVVMDVMGEVKR 423 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 A G GP+DAV+ I I L +YS+TA G DA G+V + NG G G Sbjct: 424 AAGFGVGPIDAVFNVIGEIVGRAPVLERYSVTAITGGTDAQGEVTVRLRQNGSSAVGRGS 483 Query: 481 ATDIVESSAKAMVHVLNNI 499 DI+ +SA+A V+ LN + Sbjct: 484 DPDIILASARAYVNALNRL 502 >UniRef50_B8J4F8 2-isopropylmalate synthase n=3 Tax=Desulfovibrionales RepID=B8J4F8_DESDA Length = 515 Score = 591 bits (1524), Expect = e-167, Method: Composition-based stats. Identities = 245/518 (47%), Positives = 329/518 (63%), Gaps = 5/518 (0%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+ +V FDTTLRDGEQ+ A+++++EKL++A LE +GVD+ME GFP SSPGDFESVQ Sbjct: 1 MNNRVYFFDTTLRDGEQSPGATMNLQEKLRLAHQLEVLGVDIMEAGFPASSPGDFESVQR 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 IA Q + +V LARCV DID E++K A RIH F++TSP+H+ KLR D+V+ Sbjct: 61 IAAQAGDIQVAGLARCVAGDIDRCWEAIKNARNPRIHIFLSTSPLHMRHKLRKDPDDVLR 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 A+ VKR YTD+VEFSCED R+ L RVVEA I AGATT+N+PDTVGY P E+ Sbjct: 121 MAVEGVKRCAMYTDNVEFSCEDFSRSEPEFLCRVVEAVIKAGATTVNLPDTVGYAQPAEY 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 A I + PN DKA+ SVH H+DLGLAV N+LAA G RQ E +NGIGERAGN S Sbjct: 181 AARIEHVISNTPNSDKAVFSVHCHNDLGLAVANTLAAFRVGVRQAEVTLNGIGERAGNAS 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV+M ++VR+D + I ++++ + +L+S PIP NKAIVG+ AFAH SGIH Sbjct: 241 LEEVVMNLRVRQDYFGLEHNIVTEQLYPSCRLLSMTIGQPIPNNKAIVGANAFAHESGIH 300 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 QDG+LKNRE YEIMTP+S+G + L + SGR AV+++ + MGYK + L+ +++A Sbjct: 301 QDGMLKNRETYEIMTPQSVGRTESNLVIGKHSGRNAVRNKFEAMGYKLDDDQLNLIFEAV 360 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSG--SNDIATAAVKLACGEEV 418 +LAD+K + D DL AL + P+ FRL + SVQS TAAV + + Sbjct: 361 KQLADRKKNLHDDDLMALVQEEIYRA-PDRFRLRHVSVQSSDTGGVPPTAAVIMDVDGKE 419 Query: 419 KAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGV 478 + A G GPVDA++ I + EL +Y++ A G DALG+V + G Sbjct: 420 SSGAGFGVGPVDALFNVIADMVGREAELEQYAINAITGGTDALGEVTVRLRDGEYSAVGR 479 Query: 479 GLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHN 516 G DI +SA+A V+ LN++ + E L QH+ Sbjct: 480 GTHPDIFVASARAYVNALNHLAKKEEEGPRLH--CQHD 515 >UniRef50_B7GH19 2-isopropylmalate synthase n=98 Tax=cellular organisms RepID=LEU1_ANOFW Length = 514 Score = 583 bits (1504), Expect = e-165, Method: Composition-based stats. Identities = 241/513 (46%), Positives = 334/513 (65%), Gaps = 1/513 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ IFDTTLRDGEQ+ +L++ EKL+IA LER+GVD++E GFP +S GDF++VQ IA Sbjct: 2 RKINIFDTTLRDGEQSAGVNLNLHEKLEIARQLERLGVDIIEAGFPAASKGDFQAVQAIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 + V+N V L+R V+ DID A E+LK R+H FIATSP+H+ KLR T ++V+E A Sbjct: 62 QTVRNCSVTGLSRSVQSDIDAAWEALKDGAEPRLHVFIATSPIHMQYKLRMTPEQVVETA 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + V+ A+ Y V++S EDA R+ + LA +VE I AGA INIPDTVGY P ++ Sbjct: 122 VESVRYAKKYFPIVQWSAEDACRSDLPFLATIVEKVIEAGANVINIPDTVGYITPKQYGD 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I S L + V NI+K +S H HDDLG+AV NSLAA+ AGA Q+EG +NGIGERAGN ++E Sbjct: 182 IFSFLKKNVRNIEKISLSAHCHDDLGMAVANSLAAIEAGATQIEGTINGIGERAGNAAIE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV +A+ +RKD T +N QEI RTS LVS++ M +PANKAIVG AFAH SGIHQD Sbjct: 242 EVAVALYIRKDYYQAETRLNLQEIKRTSSLVSKLTGMIVPANKAIVGKNAFAHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 GVLK + YEI++P+ +G+ + L SGR A + R+ E+GY +E ++ L+ F Sbjct: 302 GVLKEKTTYEIISPQLVGVQSNSMVLGKHSGRHAFRTRIQELGYSLTEEEVNRLFVRFKD 361 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA-E 421 LADKK + D DL AL K ++L VQ G+N I TA V L GE E Sbjct: 362 LADKKKDITDDDLIALILDEKLDTYKNFYQLCSIQVQYGTNQIPTAVVVLKDGEGNDIQE 421 Query: 422 AANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLA 481 AA G G V+A+Y A+ + + V L+ Y + + G G+DAL QV + + + + G G A Sbjct: 422 AATGAGSVEALYNALEKALQLPVTLLDYRIESVGSGRDALAQVYVKVSLDRKEASGRGTA 481 Query: 482 TDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQ 514 D++E+SAKA +H +N ++ ++++E AQ Sbjct: 482 QDVLEASAKAYIHAVNRMFVIEKMKEEQALAAQ 514 >UniRef50_Q7UI51 2-isopropylmalate synthase n=1 Tax=Rhodopirellula baltica RepID=LEU1_RHOBA Length = 527 Score = 583 bits (1503), Expect = e-165, Method: Composition-based stats. Identities = 242/501 (48%), Positives = 335/501 (66%), Gaps = 1/501 (0%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 ++Q+ IFDTTLRDGEQ+ AS+++ EKL++A AL +GVD++E GFP++SPGDFESV+ I Sbjct: 15 TRQIRIFDTTLRDGEQSPGASMNLAEKLEVASALVDLGVDIIEAGFPIASPGDFESVRQI 74 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 A ++ + +C LARC EKDID A E+LK A RIH F+ATS +H KLR T DE++ER Sbjct: 75 ATTIRGATICGLARCAEKDIDRAWEALKTAPQARIHVFLATSAIHREFKLRMTPDEIVER 134 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 A+ V+RA ++ DDVEFS EDA RT L RVVEAAI+AGATTIN+PDTVGYT P E Sbjct: 135 AVAGVRRAASHCDDVEFSPEDACRTEHDFLCRVVEAAIDAGATTINVPDTVGYTTPGEIY 194 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 L +RVPN+DKA++S H HDDLG+AV NSLAAV AGA Q+E +NGIGERAGN +L Sbjct: 195 DRFKMLRDRVPNMDKAVLSTHCHDDLGMAVANSLAAVDAGAGQIECTINGIGERAGNAAL 254 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EE++MA+K R+D + T IN + + S+LVS+ + + NKAIVG AFAH SGIHQ Sbjct: 255 EELVMAMKTRQDFYHCQTNINSKRLVPVSRLVSKTTGINVQRNKAIVGRNAFAHESGIHQ 314 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 DG+LK R YEIM+PE +G + L L SGRAA+ R ++G + L +++AF Sbjct: 315 DGMLKERTTYEIMSPEEVGFTKTDLVLGKHSGRAALADRAKQLGMTLTGEQLQEVFEAFK 374 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGE-EVKA 420 +LADKK +++D D+ AL + + L + V SG N V L E ++ Sbjct: 375 ELADKKKEIYDGDIVALVQQKISETVAPEWTLVDYEVTSGKNQTPNVRVTLRRDEQDITE 434 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 + A G+GP+DA + A+ +IT V + + + G+DA+G+V++ + G+ + G G+ Sbjct: 435 QVAQGDGPIDAAFWAVEKITGIQVVCKDFRVRSATLGRDAIGEVNLEVEHEGKTYRGTGV 494 Query: 481 ATDIVESSAKAMVHVLNNIWR 501 +TD VES+ AM++ +N I Sbjct: 495 STDSVESTILAMLNAINRIVA 515 >UniRef50_A4YZ76 2-isopropylmalate synthase n=131 Tax=root RepID=LEU1_BRASO Length = 525 Score = 582 bits (1500), Expect = e-164, Method: Composition-based stats. Identities = 232/502 (46%), Positives = 322/502 (64%), Gaps = 1/502 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +V+IFDTTLRDGEQ A+++ +EKL IA L+ MGVD++E GFP++S GDFE+V IA Sbjct: 10 DRVVIFDTTLRDGEQCPGATMTFEEKLNIAAMLDDMGVDIIEAGFPIASDGDFEAVNEIA 69 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 ++ KN+ +C L+R KDID AE+++ A+ RIHTF++TSP+H+ KL+ +V E Sbjct: 70 KRSKNAVICGLSRAGAKDIDRCAEAIRPAKRGRIHTFLSTSPVHMKYKLQMDPQQVFELV 129 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 I V RARN+TDDVE+S ED RT L R VEAAI AGA+TINIPDTVGY +P E+ Sbjct: 130 ISSVTRARNHTDDVEWSSEDGTRTEFDFLCRCVEAAIKAGASTINIPDTVGYAVPEEYYD 189 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + + E VPN DKA+ SVH H+DLG+AV NS+A V AGARQ+E +NGIGERAGN +LE Sbjct: 190 LFKRVRETVPNSDKAVFSVHCHNDLGMAVANSMAGVRAGARQIECTINGIGERAGNAALE 249 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV+MA++VR D L I+ ++ S++VS + P+ NKAIVG AFAH SGIHQD Sbjct: 250 EVVMAMRVRNDKLPFWNKIDTTQLTHASKVVSAATSFPVQYNKAIVGRNAFAHESGIHQD 309 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G+LKN + YEIM PE++G+ Q L + SGR A H+++EMG+K S +++ + F Sbjct: 310 GMLKNAQTYEIMLPETVGVKQTSLVMGKHSGRHAFIHKLEEMGHKLSSNQVEDAFVRFKA 369 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEA 422 LAD+K Q++D D+EAL G + +L SV +G+ A +KL + E Sbjct: 370 LADRKKQIYDEDIEALIDEGMVSA-HDRIKLLSLSVIAGTRGPQRATMKLDIDGVTRIEE 428 Query: 423 ANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLAT 482 + GNGPVDAV+ I + + +L Y + A G DA +V + + +GR Sbjct: 429 SEGNGPVDAVFNCIKSLVPHEAKLELYQVHAVTEGTDAQAEVSVRLSQDGRSMTARAADP 488 Query: 483 DIVESSAKAMVHVLNNIWRAAE 504 D + +SAKA + LN + + Sbjct: 489 DTLVASAKAYLGALNKLVMKRQ 510 >UniRef50_Q2IUT4 2-isopropylmalate synthase n=119 Tax=Bacteria RepID=LEU1_RHOP2 Length = 524 Score = 579 bits (1493), Expect = e-164, Method: Composition-based stats. Identities = 232/502 (46%), Positives = 324/502 (64%), Gaps = 1/502 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +VIIFDTTLRDGEQ A+++ +EKL +A L+ MGVDV+E G+P +S GDFE+V IA Sbjct: 10 DRVIIFDTTLRDGEQCPGATMTFEEKLNVARMLDDMGVDVIEAGYPFASDGDFEAVHEIA 69 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 ++ KNS +C L+R KDID AE++K AE RIHTF++TSP+H+ KL+ +V E Sbjct: 70 KRSKNSVICGLSRASHKDIDRCAEAIKPAERGRIHTFLSTSPVHMKYKLQMEAAQVYEMV 129 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 I V RARN+TDDVE+S EDA RT L R +EAAI AGATTIN+PDTVGY +P E+ Sbjct: 130 ISSVTRARNHTDDVEWSAEDATRTEFDFLCRCIEAAIKAGATTINLPDTVGYAVPEEYRE 189 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + + E VPN DKA SVH H+DLG+AV NS+A V GARQ+E +NGIGERAGN +LE Sbjct: 190 MFRKVRETVPNSDKARFSVHCHNDLGMAVANSMAGVAGGARQIECTINGIGERAGNAALE 249 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E++MA++VR+D L I + S+ VS + P+ NKAIVG AFAH SGIHQD Sbjct: 250 ELVMAMRVRQDKLPYWNNIETTMLTHASKTVSAATSFPVQYNKAIVGRNAFAHESGIHQD 309 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G++KN + YEIMTPE++G+ L + SGRA + H+++E+GYK S +++++ F Sbjct: 310 GMIKNAQTYEIMTPETVGVKGTSLVMGKHSGRAGLIHKLEELGYKLSRNQIEDVFVRFKA 369 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEA 422 LAD+K V+D D+EAL + + +L+ +V +G++ A +KL +++ E Sbjct: 370 LADRKKDVYDEDIEALVDEQLLHGQ-DQIKLNSLTVIAGTHGPQRATMKLDVDGQIRIEE 428 Query: 423 ANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLAT 482 A GNGPVDAV+ I + ++ +L Y + A G DA +V + ++ GR Sbjct: 429 AEGNGPVDAVFNCIKALVPHDAKLELYQVHAVTEGTDAQAEVSVRLSHEGRSMTARAADP 488 Query: 483 DIVESSAKAMVHVLNNIWRAAE 504 D + +SAKA + LN I + Sbjct: 489 DTLVASAKAYLGALNKIVAKRQ 510 >UniRef50_Q2YBW0 2-isopropylmalate synthase n=2 Tax=Bacteria RepID=LEU1_NITMU Length = 510 Score = 574 bits (1481), Expect = e-162, Method: Composition-based stats. Identities = 255/508 (50%), Positives = 334/508 (65%), Gaps = 2/508 (0%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M +IIFDTTLRDGEQ+ AS++ +EK++IA LERM VDV+E GFP +S GDFE+V+ Sbjct: 1 MKDHLIIFDTTLRDGEQSPGASMTREEKVRIARQLERMRVDVIEAGFPAASNGDFEAVKA 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 +A +K S +C LAR +E DI A E+L+ A + RIHTFIATSP+H+ KLR + D+V+E Sbjct: 61 VAAAIKGSTICGLARAIEGDIRRAGEALRGANSARIHTFIATSPIHMEKKLRMSPDQVVE 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 +A+ VK AR YTDDVEFS EDAGR+ I L RV+EA I+AGA T+NIPDTVGYTMP +F Sbjct: 121 QAVKAVKFARQYTDDVEFSPEDAGRSDITFLCRVLEAVIDAGAGTVNIPDTVGYTMPQQF 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 +I L ER+PN DK I SVH H+DLGLAV NSL+AV GARQVE +NG+GERAGN S Sbjct: 181 GELIRTLRERIPNSDKVIFSVHCHNDLGLAVANSLSAVMNGARQVECTVNGLGERAGNAS 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV+MA++ R+D T I+ I S+LVS I P+ NKAIVG+ AFAH SGIH Sbjct: 241 LEEVVMAVRTRQDFFPCDTRIDSVHIVPASKLVSGITGFPVQPNKAIVGANAFAHESGIH 300 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE-SEYNLDNLYDA 359 QDGVLK+RE YEIM E +G +L L SGR A + R+ E+G + SE L+ + Sbjct: 301 QDGVLKHRETYEIMRAEDVGWGANKLLLGKHSGRNAFRSRLAELGIELESEETLNATFMR 360 Query: 360 FLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVK 419 F +LADKK +FD DL AL + EH++L + S + + A++ + Sbjct: 361 FKELADKKHDIFDEDLHALVSDDAAALQ-EHYKLLSLTAHSETGETPHASIVIGEEGRES 419 Query: 420 AEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVG 479 ++G+GPVDA ++AI +I VEL YS+ A G D+ G+V + +GR +G G Sbjct: 420 RAESDGSGPVDATFRAIEKILNSGVELQLYSVNAITSGTDSQGEVTVRLQKSGRIVNGNG 479 Query: 480 LATDIVESSAKAMVHVLNNIWRAAEVEK 507 TDIV +SAKA + LN + E Sbjct: 480 ADTDIVVASAKAYLSALNKLHSKLERAH 507 >UniRef50_A7Z7B8 2-isopropylmalate synthase n=11 Tax=Bacillales RepID=LEU1_BACA2 Length = 518 Score = 574 bits (1480), Expect = e-162, Method: Composition-based stats. Identities = 227/498 (45%), Positives = 318/498 (63%), Gaps = 2/498 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ +FDTTLRDGEQ+ +L+ +EKL IA LER+GVD++E GFP SS GDF +VQ IA Sbjct: 2 RKINVFDTTLRDGEQSPGVNLNSREKLAIAKQLERLGVDIIEAGFPASSRGDFLAVQEIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 R +KN V LAR V+ DID A E+LK + RIH FIATS +H+ KL+ T +EV E+A Sbjct: 62 RTIKNCSVTGLARSVKGDIDAAWEALKDGVSPRIHIFIATSDIHLKHKLKMTREEVKEKA 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + MVK A+ V++S EDA RT + LA +VE I+AGA+ IN+PDTVGY P E+ Sbjct: 122 VEMVKYAKERFPIVQWSAEDACRTELPFLAEIVEEVIDAGASVINLPDTVGYLTPDEYGN 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I + E VPNI + +S H HDDLG+AV NSL+A+ GA Q+E A+NGIGERAGN +LE Sbjct: 182 IFKYMKEHVPNISRVKLSAHCHDDLGMAVANSLSAIENGADQIECAINGIGERAGNAALE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E+ +A+ VR D +++N E+ RTS LVS++ M +P NKAIVG AFAH SGIHQD Sbjct: 242 EIAVALHVRNDAHQADSSLNLHELKRTSDLVSKLTGMAVPRNKAIVGDNAFAHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G LK + YEI++PE +G+ L L SGR A K R++ +G++ ++ + F + Sbjct: 302 GFLKEKSTYEIISPELVGVTADALVLGKHSGRHAFKDRLNTLGFQFDSDEINKYFTMFKE 361 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA-- 420 L +KK ++ D DL +L K ++ + V G++ + TA V L E + Sbjct: 362 LTEKKKEITDDDLISLILEEKVTDKKIGYEFLSLQVHYGTSQVPTATVSLKNQENEQLMQ 421 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 EAA G G V+AVY + R + N+EL Y + + G+DAL QV + NG+ G G+ Sbjct: 422 EAATGAGSVEAVYNTLGRCIDKNIELTDYRIQSNRKGEDALAQVFVRVTVNGKESSGRGI 481 Query: 481 ATDIVESSAKAMVHVLNN 498 A D++E+SAKA ++ +N Sbjct: 482 AQDVLEASAKAYLNAVNR 499 >UniRef50_A8FFW5 2-isopropylmalate synthase n=224 Tax=Bacilli RepID=LEU1_BACP2 Length = 517 Score = 574 bits (1479), Expect = e-162, Method: Composition-based stats. Identities = 234/512 (45%), Positives = 326/512 (63%), Gaps = 4/512 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ FDTTLRDGEQ+ +L+ +EKL IA LER+GV+++E GFP SS GDF VQ IA Sbjct: 2 RKINFFDTTLRDGEQSPGVNLNAQEKLIIAKQLERLGVNIIEAGFPASSRGDFLGVQEIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 R +KN V LARCV+ DID A E+LK R+H FIATS +H+ KL+ T +EV+E+A Sbjct: 62 RTIKNCSVAGLARCVKGDIDAAWEALKDGVEPRLHVFIATSDIHLKHKLKKTREEVVEQA 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + MVK A+ V++S EDA RT + LA +VE I+AGA+ IN+PDTVGY P E+ Sbjct: 122 VAMVKYAKERFPVVQWSAEDACRTDLDFLAEIVEKVIDAGASVINLPDTVGYLAPKEYGN 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I + E VPNID+ +S H HDDLG+AV NSLAA+ GA Q+E A+NGIGERAGN +LE Sbjct: 182 IFKYMKEHVPNIDRVNLSAHCHDDLGMAVANSLAAIENGADQIETAVNGIGERAGNAALE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E+ +A+ +RKD V + I EI RTS +VS+ M +P NKA+VG+ AFAH SGIHQD Sbjct: 242 EIAVALHIRKDFYQVESTIQLNEIKRTSDVVSKYSGMIVPRNKAVVGNNAFAHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G LK + YEI++PE +G+ L L SGR A K RM +G+K +E ++ ++ F Sbjct: 302 GFLKEKTTYEIISPELVGVTTDVLVLGKHSGRHAFKDRMKTLGFKLTEEEINKFFETFKN 361 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGE--EVKA 420 L +KK ++ D DL ++ K + + + V G+ + TA V L E EV Sbjct: 362 LTEKKKEITDDDLISIILEEKVADRKIGYEFESLQVHYGTEQMPTATVSLKNQETQEVIQ 421 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 EAA G G V+AVY + R E + L+ Y + + G G+DAL +V + + G+ G G+ Sbjct: 422 EAATGAGSVEAVYNTLERCMEERIHLLDYRIQSNGKGRDALAEVYVTVSIEGKETAGRGV 481 Query: 481 ATDIVESSAKAMVHVLNN--IWRAAEVEKELQ 510 A D++E+SAKA V+ +N I+++ +E E Sbjct: 482 AQDVLEASAKAYVNAVNRHLIFKSNLIEIEKH 513 >UniRef50_D2M1E9 2-isopropylmalate synthase n=1 Tax=Bacillus cellulosilyticus DSM 2522 RepID=D2M1E9_BACS4 Length = 514 Score = 571 bits (1471), Expect = e-161, Method: Composition-based stats. Identities = 231/500 (46%), Positives = 319/500 (63%), Gaps = 2/500 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 ++ IFDTTLRDGEQ+ +L+ EKL+IA LER GVD+ME GFP SS GDFE V+ IA Sbjct: 2 SKINIFDTTLRDGEQSPGVNLNQLEKLEIAKQLERFGVDIMEAGFPASSQGDFEGVRAIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 +KN+ V LAR + DID A ++LK A R+H F+ATSP+H+ KL+ T ++VI+ A Sbjct: 62 NTIKNASVTGLARAKKSDIDYAWDALKEAVEPRLHIFLATSPIHMTYKLKKTPEQVIQTA 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + MV A VE+S EDA R+ I L +++E I+AGAT IN+PDTVGYT P E+ Sbjct: 122 VDMVSYASKNFPHVEWSAEDASRSDIHFLVKIIEKVIDAGATVINLPDTVGYTTPQEYGD 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + + E V NIDK +S H HDDLG+AV N++AAV GA QVEG +NGIGERAGN SLE Sbjct: 182 LFKYVRENVRNIDKVTLSAHCHDDLGMAVANTIAAVENGATQVEGTINGIGERAGNASLE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E+ +A+ +R D T + EI RTS LVS++ M +P NKA+VG AFAH SGIHQD Sbjct: 242 EIAVALNIRSDKYPYTTNLVLNEIKRTSDLVSKLTGMVVPPNKAVVGRNAFAHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 GVLKN YEI+TPE +G+ L L SGR A K +++++GY+ +E L + +F Sbjct: 302 GVLKNASTYEIITPELVGIQSNNLVLGKHSGRHAFKDKIEQLGYELAEDKLLEAFQSFKL 361 Query: 363 LADKKGQVFDYDLE-ALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAE 421 L D+K +V D DL L I + + + L+ F VQ GS+++ TA V L E + E Sbjct: 362 LTDRKKEVTDDDLFTILTDIQTDTSDVKKYELEAFQVQYGSSNLPTATVALTTPEGERVE 421 Query: 422 AA-NGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 A G+G V+A+Y + + + + L ++L++ G G+DAL V I N G G Sbjct: 422 TACTGSGSVEALYNTLEALIKEKIHLTDFNLSSVGQGRDALADVHIKMTVNDTPVSGRGT 481 Query: 481 ATDIVESSAKAMVHVLNNIW 500 A D++E+SAKA ++ +N ++ Sbjct: 482 AQDVLEASAKAFLNAVNRVF 501 >UniRef50_A3PDH0 2-isopropylmalate synthase n=42 Tax=cellular organisms RepID=LEU1_PROM0 Length = 546 Score = 569 bits (1468), Expect = e-161, Method: Composition-based stats. Identities = 240/537 (44%), Positives = 341/537 (63%), Gaps = 18/537 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 +++IFDTTLRDGEQ+ ASL+++EKL IA L R+GVDV+E GFP +SPGDF++V I Sbjct: 5 PGRILIFDTTLRDGEQSPGASLNLEEKLAIAHQLARLGVDVIEAGFPFASPGDFKAVNKI 64 Query: 62 ARQVKN---SRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEV 118 A V +C LAR + DI E++ A RIHTFIATS +H+ KL+ + +V Sbjct: 65 ASAVGKEHGPTICGLARASKGDIKACYEAVSPAPKKRIHTFIATSDIHLKHKLKKSRKDV 124 Query: 119 IERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 ++ MV A++ DD+EFSCEDA R+ L V++ AI+AGATTINIPDTVG+T P Sbjct: 125 LQIVPEMVNYAKSLVDDIEFSCEDASRSDPDFLYEVIQLAISAGATTINIPDTVGFTTPS 184 Query: 179 EFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGN 238 EF +I+ + + VPNID+A+ISVH H+DLGLAV N L AV GARQ+E +NGIGERAGN Sbjct: 185 EFGNLIADINKNVPNIDEAVISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGN 244 Query: 239 CSLEEVIMAIKVRK-----------DILNVHTAINHQEIWRTSQLVSQICNMPIPANKAI 287 SLEE++MA+ VRK D TAI +EI +TS+LVS + M + NKAI Sbjct: 245 ASLEELVMALHVRKSFFNSFFKRNPDSPTPLTAIRTEEITKTSRLVSNLTGMTVQPNKAI 304 Query: 288 VGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK 347 VG+ AFAH SGIHQDGVLKNR YEI+ +++GL+ +++L SGR+AV+ R++EMGY Sbjct: 305 VGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNKISLGKLSGRSAVRARLEEMGYD 364 Query: 348 ESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIAT 407 S +L++ + F LAD+K ++ D DLEA+ + Q F+L V G+ T Sbjct: 365 LSREDLNDAFARFKDLADRKREITDRDLEAIVSE-QVQLPEAKFQLSLVQVSCGNASKPT 423 Query: 408 AAVKLACGEEVKAEAAN--GNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVD 465 A + L E+ + A G GPVDAV +A+N++ + EL+++S+ + G DALG+V Sbjct: 424 ATISLLNTEDNTEDTAVSIGTGPVDAVCEALNKLAKVPNELIEFSVKSVTEGIDALGEVT 483 Query: 466 IVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKET 522 I + + + G TD+V ++A A ++ LN + + + + + + EN+ T Sbjct: 484 IRIRRDNKIYSGHSADTDVVVAAANAYINALNRLVFSEKKNS-IHPQFDNLENSNNT 539 >UniRef50_Q72JC9 2-isopropylmalate synthase n=4 Tax=Thermaceae RepID=Q72JC9_THET2 Length = 520 Score = 559 bits (1441), Expect = e-157, Method: Composition-based stats. Identities = 230/498 (46%), Positives = 311/498 (62%), Gaps = 2/498 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + + IFDTTLRDGEQ+ +LS+ +KL+IA AL ++ VD++E GFPVS P +FE+V+ IA Sbjct: 5 RHIRIFDTTLRDGEQSPGVALSLDQKLEIAQALAQLNVDIIEAGFPVSGPMEFEAVRRIA 64 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 +VK + ALAR DID AA++L+ AE RIH F + S +H+ LR T +EV+E A Sbjct: 65 TEVKGPIIAALARTHTLDIDQAAKALEKAEKPRIHVFTSASKVHLQYMLRKTEEEVLEMA 124 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 MV+ AR Y DDVEFS +D R + R+ E AI AGATTINIPDT GY P E+ Sbjct: 125 DRMVRYARRYVDDVEFSAQDVMRADWEFVKRLYEVAIEAGATTINIPDTTGYGTPQEYGA 184 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 +I + + V IIS HTHDDLG+A N+LA V GA Q+E +NGIGERAGNC+LE Sbjct: 185 LIRRIRDEVVRGRDVIISTHTHDDLGMATANALAGVENGAGQIECTINGIGERAGNCALE 244 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV+MA+ VR+D +T IN +EI+R S+LV + MP+P NKAIVG AFAH SGIHQD Sbjct: 245 EVVMALYVRRDWYKAYTRINTREIYRVSRLVERYTGMPVPPNKAIVGDNAFAHESGIHQD 304 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK-ESEYNLDNLYDAFL 361 GV+K+R YEIM E IG L L SGRAA K ++++GYK SE + L+ F Sbjct: 305 GVIKHRATYEIMDAELIGRRPAVLVLGKHSGRAAFKKALEDLGYKDLSEEEVKKLFARFK 364 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAE 421 ++A+KKG + +L+AL ++ F+L++ SGS + TA VK+ + + Sbjct: 365 EIAEKKGPLSAEELQALVESEREPTSH-FFQLEHVQFFSGSGLLPTATVKVKTPDGERVA 423 Query: 422 AANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLA 481 G+GPVDAVY+AI EL Y + A +ALGQV + + GVG++ Sbjct: 424 THTGDGPVDAVYKAIQEAIGLRPELELYRVEAITGSTEALGQVTVRLRLGELQAVGVGVS 483 Query: 482 TDIVESSAKAMVHVLNNI 499 DI+E+SA A + + Sbjct: 484 PDIIEASALAFLDAAGKL 501 >UniRef50_A6EER4 2-isopropylmalate synthase n=3 Tax=Sphingobacteriales RepID=A6EER4_9SPHI Length = 502 Score = 557 bits (1437), Expect = e-157, Method: Composition-based stats. Identities = 233/499 (46%), Positives = 323/499 (64%), Gaps = 1/499 (0%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 +V +FDTTLRDGEQ LS EK++IA ALE +GVDV+E GFP+SSPGDF+SV + Sbjct: 5 PNRVYVFDTTLRDGEQVPGCQLSTPEKIEIAKALEALGVDVIEAGFPISSPGDFQSVVEM 64 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 ++ V+ +CAL R + DID A +L+ A+ RIHT I +S MHI K ST ++++ER Sbjct: 65 SKAVQEPIICALTRANKGDIDSAVAALQYAKRPRIHTGIGSSDMHIKYKFNSTREKILER 124 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 A+ VK A+ + +D+EF EDAGR LA++VEA I AGAT +NIPDT GY +P ++ Sbjct: 125 AVDAVKYAKQFVEDIEFYAEDAGRADNVFLAQMVEAVIAAGATVVNIPDTNGYCLPDQYG 184 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 I L E V NID+AIISVH H+DLGLA N+LA + GARQ+E +NGIGERAGN +L Sbjct: 185 SKILYLKENVKNIDQAIISVHCHNDLGLATANTLAGIVNGARQIECTINGIGERAGNTAL 244 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EEV+M +K + ++T IN + S +VS++ MP+ NKAI+G AFAHSSGIHQ Sbjct: 245 EEVVMILKTHHAL-GLNTNINAKHFSDISNMVSRMMRMPVQPNKAIIGQNAFAHSSGIHQ 303 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 DG LK+RENYEIM PE +G+N + LT+RSGR A+KH ++ +GY+ NLD +Y+ FL Sbjct: 304 DGFLKHRENYEIMNPEDVGINSADIILTARSGRHALKHHLERLGYEIERLNLDQVYERFL 363 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAE 421 LAD+K + D D+ +L GK+ ++L V G TA++KL K Sbjct: 364 ILADEKKAISDDDIHSLMSDGKEDSYKNGYKLTLLQVLCGDPLSPTASIKLEHNGVEKEA 423 Query: 422 AANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLA 481 A+GNGPV+A AI I ++EL ++++ A G D + +V+I G+ + G G + Sbjct: 424 MASGNGPVNATINAIQSIVGADIELKEFTIQAVNGGSDDVSKVNIRIASEGKSYVGHGFS 483 Query: 482 TDIVESSAKAMVHVLNNIW 500 TDIV++SA A + +N Sbjct: 484 TDIVKASAYAYLDAMNKFM 502 >UniRef50_B6YRN0 2-isopropylmalate synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YRN0_AZOPC Length = 504 Score = 552 bits (1423), Expect = e-155, Method: Composition-based stats. Identities = 242/497 (48%), Positives = 331/497 (66%), Gaps = 3/497 (0%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 V IFDTTLRDGEQ L+ EK+Q+A +LE +GVD++E GFP+SSPGDF SV I++ Sbjct: 10 SVFIFDTTLRDGEQVPGCQLNTIEKIQVAQSLESLGVDIIEAGFPISSPGDFNSVIEISK 69 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 V + +CAL R +EKDID+AAESL+ A+ RIHT I TSP HI K ST DE++ERA+ Sbjct: 70 SVTWTIICALTRAIEKDIDIAAESLQYAKRKRIHTGIGTSPYHIKYKFNSTQDEILERAV 129 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 VK A+ Y +D+EF CEDAGRT LAR+VEA I AGA +NIPDT GY +P E+ Sbjct: 130 ASVKYAKKYVEDIEFYCEDAGRTDNVYLARIVEAVIKAGAKVVNIPDTTGYCLPEEYGAK 189 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 I L + V I I+S H H+DLG+A N+++ + GARQVE +NGIGERAGN SLEE Sbjct: 190 IKFLMDNVKGIQNVILSTHCHNDLGMATANTISGIINGARQVEVTINGIGERAGNTSLEE 249 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 V+M IK K++ N+ T IN + I+ S+++S + NMP+ NKAIVG AFAHSSGIHQDG Sbjct: 250 VVMIIKSHKEL-NIGTNINTKHIYPISRMISSLMNMPVQPNKAIVGRNAFAHSSGIHQDG 308 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 +LKNRENYEI+ P+ IG++ + LT+RSGRAA+K+R++ +G + S+ LD++Y+ FLKL Sbjct: 309 ILKNRENYEIIDPKDIGIDNNIIALTARSGRAALKYRLNILGIELSQKKLDDIYEEFLKL 368 Query: 364 ADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAA 423 AD K + D D+ LA GK + E RL+Y V SG + A++ L E AA Sbjct: 369 ADYKKNINDDDILMLA--GKDRTESNRIRLEYLQVTSGVGILPVASICLNIAGEKFEAAA 426 Query: 424 NGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATD 483 +GNGPVDA +A+ +I + + ++ + A G + +G+V + YN ++G TD Sbjct: 427 SGNGPVDAAIRAVKQIIHRQMVIQEFLIQAINKGSNDVGKVHMQVKYNDVNYYGFAANTD 486 Query: 484 IVESSAKAMVHVLNNIW 500 IV +S +A + +N Sbjct: 487 IVAASVEAFIDAINKFV 503 >UniRef50_A3DF94 2-isopropylmalate synthase n=3 Tax=Clostridium thermocellum RepID=A3DF94_CLOTH Length = 511 Score = 551 bits (1421), Expect = e-155, Method: Composition-based stats. Identities = 219/495 (44%), Positives = 312/495 (63%), Gaps = 3/495 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ IFDTTLRDGEQ +L+++EK+ IA L R+GVDV+E GFP++SPGDFE+VQ IA Sbjct: 2 RRIRIFDTTLRDGEQTPGVNLNIQEKVDIAKQLARLGVDVIEPGFPLTSPGDFEAVQRIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 R+V+ +C +R + +DID +++K A+ H FI++S + I +L T +V+E Sbjct: 62 REVEGPYICGFSRAIIRDIDETWKAIKDAQKKCFHIFISSSDIQIKHQLGKTEKDVLEIV 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 V A+ YTD+VE+S DA RT + L V+EAAI+ GAT INIPDTVGY P EF Sbjct: 122 KSTVYHAKQYTDEVEYSPMDASRTRLEFLYEVIEAAIDNGATVINIPDTVGYATPIEFGE 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 +I + + V NIDKAIISVH H+DLG+AV NS+ A GA+Q+E +NG+GERAGN +LE Sbjct: 182 LIQKIRKNVRNIDKAIISVHCHNDLGMAVANSIVAAMNGAQQIECTINGVGERAGNAALE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV+ I RKD L T I+ ++++TS++VS+ +PIP NK IVG F H SGIHQD Sbjct: 242 EVVTHIAARKDYLGFETGIDLSQLYKTSKIVSRYMGIPIPVNKPIVGKNVFTHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 GVLK R YE++ P +G + + L SGR A+K +++GY E L+ L++ F K Sbjct: 302 GVLKERSTYEVIDPRLVGRDDSVILLGKHSGRHALKVEAEKLGYDLDEERLNKLFNDFKK 361 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEA 422 L D K V DLE+L + E + L+ V SG+ + +A V + + EA Sbjct: 362 LTDVKKNVTTADLESLIIESAAKAVEEAYVLEKIRVVSGNIETPSAKVVIKDSKGNLLEA 421 Query: 423 A-NGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVG 479 GNGPVDAV++AIN + + N+ L KYS++A ++LG+V + + + G+G Sbjct: 422 EQTGNGPVDAVFKAINSVIKETENLTLYKYSVSAVTEEMESLGEVSVTLREKEKLYTGIG 481 Query: 480 LATDIVESSAKAMVH 494 TDI+ SSA A + Sbjct: 482 THTDIITSSAIAYID 496 >UniRef50_A6LDN1 2-isopropylmalate synthase n=6 Tax=Bacteria RepID=A6LDN1_PARD8 Length = 500 Score = 549 bits (1414), Expect = e-154, Method: Composition-based stats. Identities = 247/501 (49%), Positives = 327/501 (65%), Gaps = 4/501 (0%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 MS ++ IFDTTLRDGEQ L+ EK+Q+A ALE++GVDV+E GFPVSSPGDF+SV Sbjct: 1 MSDRLFIFDTTLRDGEQVPGCQLNTVEKIQVAKALEQLGVDVIEAGFPVSSPGDFKSVVE 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I++ V +CAL R VEKDIDVAAE+L+ A+ RIHT I TS HI K ST +E+IE Sbjct: 61 ISKAVTWPTICALTRAVEKDIDVAAEALRFAKRGRIHTGIGTSDSHIKYKFNSTREEIIE 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 RAI K A+ Y +DVEF CEDAGRT LARVVEA I AGAT +NIPDT GY +P E+ Sbjct: 121 RAIAATKYAKKYVEDVEFYCEDAGRTDNEYLARVVEAVIKAGATVVNIPDTTGYCLPDEY 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 I L E V + AI+S H H+DLG+A N++ V GARQVE +NGIGERAGN S Sbjct: 181 GAKIKYLMEHVDGVHNAILSTHCHNDLGMATANTVQGVLNGARQVEVTINGIGERAGNTS 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV M K K+ ++ T I +I+ TS++VS + NMP+ NKAIVG AFAHSSGIH Sbjct: 241 LEEVAMVFKSHKE-RDIITNITTNKIYSTSRMVSSLMNMPVQPNKAIVGRNAFAHSSGIH 299 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 QDGVLKN + YEI+ P+ +G++ + LT+RSGRAA+KHR+ +G + LD +YD F Sbjct: 300 QDGVLKNAQTYEIIDPKDVGIDDNAIVLTARSGRAALKHRLHVLGVDLEQEKLDKVYDEF 359 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 LKLAD+K + D D+ L +GK + +L+Y V SG + A++ L + Sbjct: 360 LKLADRKKDINDDDV--LMLVGKDRTATHRIKLEYLQVTSGVGVQSVASICLNLSGVRRY 417 Query: 421 EAANGNGPVDAVYQAINR-ITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVG 479 EAA GNGPVDA +A+ + I+ ++ + ++ + A G D G+V + YNG ++G Sbjct: 418 EAAAGNGPVDAGIKAVKKAISNSDMTIQEFLIQAINKGSDDTGKVHMQVEYNGATYYGFS 477 Query: 480 LATDIVESSAKAMVHVLNNIW 500 TDI+ +S +A V +N Sbjct: 478 ANTDIIAASVEAFVDAINKFI 498 >UniRef50_B8J824 2-isopropylmalate synthase n=7 Tax=Bacteria RepID=B8J824_ANAD2 Length = 523 Score = 549 bits (1414), Expect = e-154, Method: Composition-based stats. Identities = 241/516 (46%), Positives = 333/516 (64%), Gaps = 2/516 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 Q+V IFDTTLRDGEQ+ AS+++ +KLQ+A AL +GVDV+E GF +SPGD E++Q + Sbjct: 6 QRVTIFDTTLRDGEQSPGASMNLGQKLQVARALRDLGVDVIEAGFAAASPGDLEAIQAVG 65 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 RQV+ V +L+RC + DI+ + ++L A R H F+ATSP+H KL+ DE+I+R+ Sbjct: 66 RQVEGPIVASLSRCNKGDIEASWKALADAPRRRCHVFLATSPIHRDFKLKLAKDEIIKRS 125 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + VK AR DDVEFS ED+ RT + LA VVE I AG T+NIPDTVGY +P +A Sbjct: 126 VDGVKLAREKFDDVEFSAEDSARTELEFLAEVVERVIEAGVGTVNIPDTVGYALPSTYAE 185 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I L + V I+KA+ISVH H+DLG+AV NSLA V GARQVE +NGIGERAGN SLE Sbjct: 186 TIRYLRKHVRGIEKAVISVHCHNDLGMAVANSLAGVLEGARQVECTINGIGERAGNASLE 245 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E++MA K R D+L V T + + ++ TS+LVSQ+ + + NKAIVG AFAH +GIHQ Sbjct: 246 EIVMAFKTRHDVLGVTTGVQTERLFPTSRLVSQVTGLHVQRNKAIVGQNAFAHEAGIHQH 305 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G+L NRE YEIM PE +G + QL L SGR A+K R+ +GY+ E +D ++ F Sbjct: 306 GMLTNRETYEIMRPEEVGFARSQLVLGKHSGRHALKDRLLALGYQLDEAQIDKVFADFKV 365 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPE-HFRLDYFSVQSGSNDIATAAVKLA-CGEEVKA 420 LADKK ++D D+EAL G+ + + L+ S SG+ + A+V L E Sbjct: 366 LADKKKDIYDADIEALVVHGQILGKGSVAWELEALSTTSGTGTLPCASVALRSAAGERIQ 425 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 EAA G+GPVDAVY+AI ++T +++L Y + + G+DA G+V I + + G L Sbjct: 426 EAAAGDGPVDAVYRAIEKVTGISLKLRDYQIASVSRGEDAQGEVSIEVEHPTGVYRGRAL 485 Query: 481 ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHN 516 +TDI+E SA+A + V+N I E + +A+ Sbjct: 486 STDIIEGSARAFLDVVNRIALKMPPPTESEARAEMG 521 >UniRef50_Q5F8D4 2-isopropylmalate synthase n=73 Tax=cellular organisms RepID=LEU1_NEIG1 Length = 517 Score = 548 bits (1413), Expect = e-154, Method: Composition-based stats. Identities = 227/499 (45%), Positives = 324/499 (64%), Gaps = 1/499 (0%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 + +VIIFDTTLRDGEQ+ A+++ +EK+++A LE++G D++E GF +SPGDFE+V I Sbjct: 4 ANRVIIFDTTLRDGEQSPGAAMTKEEKIRVARQLEKLGADIIEAGFAAASPGDFEAVNAI 63 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 A+ + S VC+L+R +E+DI A +++ A RIHTFIATSP+H+ KL+ +VIE Sbjct: 64 AKTITKSTVCSLSRAIERDIRQAGKAVAPAPKKRIHTFIATSPIHMEYKLKMKPKQVIEA 123 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 A+ VK AR YTDDVEFSCEDA R+ I LA + A I AGATTINIPDTVGY++P++ Sbjct: 124 AVKAVKIAREYTDDVEFSCEDALRSQIDFLAEICGAVIEAGATTINIPDTVGYSIPYKTE 183 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 L + PN K + S H H+DLGLAV NSLAA+ GARQVE +NG+GERAGN S+ Sbjct: 184 EFFRELIAKTPNGGKVVWSAHCHNDLGLAVANSLAALKGGARQVECTVNGLGERAGNASV 243 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EE++MA+KVR D+ + T I+ +I +S+LVS I P+ NKAIVG+ AF+H SGIHQ Sbjct: 244 EEIVMALKVRHDLFGLETGIDTTQIVPSSKLVSTITGYPVQPNKAIVGANAFSHESGIHQ 303 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE-SEYNLDNLYDAF 360 DGVLK+RE YEIM+ ES+G + +L+L SGR A K ++ ++G + SE L+ + F Sbjct: 304 DGVLKHRETYEIMSAESVGWSANRLSLGKLSGRNAFKTKLADLGIELESEEALNAAFARF 363 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 +LADKK ++FD DL AL E ++ + + + + A + E K Sbjct: 364 KELADKKREIFDEDLHALVSDEMGNMNAESYKFISQKISTETGEEPRADIVFGIKGEEKR 423 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 +A G+GPVDA+++AI + + L YS+ A G ++ G+ + R +G G Sbjct: 424 ASATGSGPVDAIFKAIESVAQSGATLQIYSVNAVTQGTESQGETSVRLARGNRVVNGQGA 483 Query: 481 ATDIVESSAKAMVHVLNNI 499 TDI+ ++AKA + L+ + Sbjct: 484 DTDILAATAKAYLSALSKL 502 >UniRef50_Q9C550 2-isopropylmalate synthase 2, chloroplastic n=59 Tax=cellular organisms RepID=LEU12_ARATH Length = 631 Score = 544 bits (1402), Expect = e-153, Method: Composition-based stats. Identities = 235/533 (44%), Positives = 325/533 (60%), Gaps = 32/533 (6%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 V IFDTTLRDGEQ+ A+L+ KEKL IA L ++GVD++E GFP +S DFE+V+TI Sbjct: 84 PNYVRIFDTTLRDGEQSPGATLTSKEKLDIARQLAKLGVDIIEAGFPAASKDDFEAVKTI 143 Query: 62 ARQVKN--------SRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRS 113 A V N +C L+RC +KDI+ A E++K A+ RIHTFIATS +H+ KL+ Sbjct: 144 AETVGNTVDENGYVPVICGLSRCNKKDIETAWEAVKYAKRPRIHTFIATSDIHLKYKLKK 203 Query: 114 TLDEVIERAIYMVKRARNYT-DDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTV 172 + +EVIE A MV+ AR+ +DVEFS EDAGR+ L ++ I AGATT+NIPDTV Sbjct: 204 SKEEVIEIARNMVRFARSLGCEDVEFSPEDAGRSEREYLYEILGEVIKAGATTLNIPDTV 263 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G T+P EF +I+ + P I IIS H +DLGL+ N+L+ H+GARQVE +NGI Sbjct: 264 GITLPSEFGQLIADIKANTPGIQNVIISTHCQNDLGLSTANTLSGAHSGARQVEVTINGI 323 Query: 233 GERAGNCSLEEVIMAIKVRKD--ILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGS 290 GERAGN SLEEV+MAIK R D + + T I+ + I TS++V + M +KAIVG+ Sbjct: 324 GERAGNASLEEVVMAIKCRGDHVLGGLFTGIDTRHIVMTSKMVEEYTGMQTQPHKAIVGA 383 Query: 291 GAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQ---IQLNLTSRSGRAAVKHRMDEMGYK 347 AFAH SGIHQDG+LK++ YEIM+PE IGL + + L SGR A+K R++E+GY Sbjct: 384 NAFAHESGIHQDGMLKHKGTYEIMSPEEIGLERSNDAGIVLGKLSGRHALKDRLNELGYV 443 Query: 348 ESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEH-FRLDYFSVQSGSNDIA 406 + L NL+ F +A++K +V D DL AL + + +PE ++L + G+ ++ Sbjct: 444 LDDGQLSNLFWRFKAVAEQKKRVTDADLIAL--VSDEVFQPEAVWKLLDMQITCGTLGLS 501 Query: 407 TAAVKLACGEEVKAEAAN-GNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVD 465 T+ VKLA + + A + G GPVDA Y+A++ I + L++YS+ A G DA+ Sbjct: 502 TSTVKLADSDGKEHVACSVGTGPVDAAYKAVDLIVKEPATLLEYSMNAVTEGIDAIATTR 561 Query: 466 IVANYN--------------GRRFHGVGLATDIVESSAKAMVHVLNNIWRAAE 504 ++ + R F G G DIV SS KA V LN + E Sbjct: 562 VLIRGDNNYSSTNAVTGESVERTFSGTGAGMDIVVSSVKAYVGALNKMLGFKE 614 >UniRef50_B3DX88 2-isopropylmalate synthase n=12 Tax=Bacteria RepID=LEU1_METI4 Length = 506 Score = 544 bits (1401), Expect = e-153, Method: Composition-based stats. Identities = 241/502 (48%), Positives = 343/502 (68%), Gaps = 4/502 (0%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 + ++I+FDTTLRDGEQ AS++ ++KL++A L R+GVDV+E GFPV S GDFESV I Sbjct: 5 ANRLIVFDTTLRDGEQCPGASMTSRQKLEVAKQLARLGVDVIEAGFPVISQGDFESVSEI 64 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAF-RIHTFIATSPMHIATKLRSTLDEVIE 120 A QVK ++C LARC+ KDI+ AAE+LK A RIH F+ATS +H KL +E++ Sbjct: 65 AAQVKGPKICGLARCLPKDIEAAAEALKAAADAARIHVFLATSQIHRRFKLAKDEEEIVR 124 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 A+ V+ A+ Y DVEFS EDA RT LA++++ I AGATT+NIPDTVGY +P EF Sbjct: 125 IAVEGVRLAKRYVQDVEFSAEDASRTEPEFLAKIIQKVIEAGATTVNIPDTVGYAVPEEF 184 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 A +I L++ V +IDK ++SVH H+DLGLAV NSLAA+ AGARQVEG +NGIGERAGN + Sbjct: 185 ASLIRYLFDHVQDIDKVVVSVHCHNDLGLAVSNSLAAIKAGARQVEGTINGIGERAGNAA 244 Query: 241 LEEVIMAIKVRKD-ILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 LEE+IMA+ R D + T I +EI RTS+LVS++ + + NKA+VG AFAH++GI Sbjct: 245 LEEIIMALHTRPDAFGKIETGIQLKEILRTSRLVSRMSGLAVQRNKAVVGENAFAHAAGI 304 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 HQDG+LK RE YEI+ P+ IG Q +L LT SGRAA+++R+ +G++ + +DN++ Sbjct: 305 HQDGILKKRETYEIIDPKIIGWEQSELPLTKHSGRAALENRLKILGFELEKEEIDNIFSQ 364 Query: 360 FLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVK 419 F ++ DKK ++D DL +L G+ E + L+Y +V S I A +KL GEEV Sbjct: 365 FKQIGDKKKFIYDDDLVSLV-EGQISRIKETYELEYVAVTVCSGGIPMATIKLRHGEEVL 423 Query: 420 AEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRR-FHGV 478 +A+ G+G VDA +A++RIT + LV+Y + + GKDA+G+V + N++ ++ Sbjct: 424 VDASTGDGAVDAAMKAVDRITGQHGHLVEYEVKSVTEGKDAIGEVTVKVNFDSKKLVTAK 483 Query: 479 GLATDIVESSAKAMVHVLNNIW 500 +TD++E+S KA ++ +N Sbjct: 484 AASTDVIEASIKAYLNAVNKAL 505 >UniRef50_D0MYD7 2-isopropylmalate synthase n=2 Tax=Phytophthora infestans T30-4 RepID=D0MYD7_PHYIN Length = 576 Score = 536 bits (1382), Expect = e-151, Method: Composition-based stats. Identities = 235/535 (43%), Positives = 323/535 (60%), Gaps = 35/535 (6%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++++FDTTLRDGEQ+ A+L+ KEKL IA AL +GVDV E GFP+SSPGDF++V IA Sbjct: 32 ERLVLFDTTLRDGEQSPGATLNFKEKLDIARALSTLGVDVCEAGFPISSPGDFDAVSAIA 91 Query: 63 RQV----------KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLR 112 +++ + +C LAR +EKDI +++K A RIHTF+ATS +H+ KL+ Sbjct: 92 KEIGPITAGRPTGEPMTICGLARAMEKDIQRCYDAVKHAPKHRIHTFLATSDIHLQYKLK 151 Query: 113 STLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTV 172 + DE I RA+ VK A++ T DVEFS EDAGR+ L V+ I AGATT+NIPDTV Sbjct: 152 ISRDECIRRAVDAVKFAKSLTPDVEFSTEDAGRSDPDFLCDVLAEVIKAGATTLNIPDTV 211 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 GYT+P E+ + S L + DKAI S H H+DLGLA N+LAAV GARQ E +NGI Sbjct: 212 GYTVPGEYGSLFSYLIDNTEGSDKAIFSTHCHNDLGLATANTLAAVQGGARQAEVTINGI 271 Query: 233 GERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 GERAGN +LEE++MA+K R V+T+++ +I R S++VS M I NKAIVGS A Sbjct: 272 GERAGNTALEELVMALKTRPQHFPVYTSVDSTQITRCSRMVSHYTGMSIQPNKAIVGSNA 331 Query: 293 FAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGY-KESEY 351 FAH SGIHQDGVLK++ YEIM PES+GL++ ++ L SGR A R+ ++GY + Sbjct: 332 FAHESGIHQDGVLKHQATYEIMLPESVGLSENKMVLGKHSGRHAYSKRLQQLGYTNLTPE 391 Query: 352 NLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVK 411 LD + F LAD+K V D D+EA+ + E + L V +G+ TA V Sbjct: 392 ELDYYVEKFKVLADEKKTVTDADMEAIVSDELFKPET-FWTLQSVHVTAGNLVKPTATVT 450 Query: 412 L-ACGEEVKAEAANGNGPVDAVYQAINRITEYN-VELVKYSLTAKGHGKDALGQVDIVAN 469 L + +EAA G GP+DA+Y AI R T ++L +S+ + G ALG+V + Sbjct: 451 LAHKDGQEVSEAAMGTGPIDAIYVAIKRATGMESIKLNDFSVESVTDGTYALGEVTVRVQ 510 Query: 470 YN---------------------GRRFHGVGLATDIVESSAKAMVHVLNNIWRAA 503 + R+F G G TDI+ +SA A V+ +N + + Sbjct: 511 EDKEEEEKTEGEKHVNAQTGVTRDRQFVGHGANTDILVASATAYVNAVNRMMASQ 565 >UniRef50_C7JAV8 2-isopropylmalate synthase n=8 Tax=Acetobacter pasteurianus RepID=C7JAV8_ACEP3 Length = 547 Score = 536 bits (1381), Expect = e-151, Method: Composition-based stats. Identities = 231/510 (45%), Positives = 311/510 (60%), Gaps = 5/510 (0%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 +VI+FDTTLRDGEQ+ S+++ EKL++A AL +GVDV+E GFPV+S GDFESV I Sbjct: 36 PDRVIVFDTTLRDGEQSPGFSMNLAEKLRMAEALANLGVDVIEAGFPVASKGDFESVNEI 95 Query: 62 ARQVKNSRVCALAR-CVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 A+ K S +CALAR KDI A E+L AE RIH FI+TSP+H+ KLR + V+E Sbjct: 96 AKNTKGSVICALARSGGVKDIAAAGEALAPAERKRIHNFISTSPLHMKYKLRMEPETVLE 155 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 ARN TDDVE+S ED RT L R VEAAI AGATTINIPDTVGY P + Sbjct: 156 LITSGNAAARNLTDDVEWSAEDGSRTEPDFLCRCVEAAIKAGATTINIPDTVGYATPEDM 215 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 I S L +RVP D+ I S H H+DLGLAV N+LA++ GARQVE +NGIGERAGN + Sbjct: 216 EKIFSMLRQRVPGADQVIFSAHNHNDLGLAVANTLASIRGGARQVECTINGIGERAGNAA 275 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEE++MA++ R D T I+ + + + S++++ I + + NKAIVG AFAH SGIH Sbjct: 276 LEEIVMALRTRHDQYPFTTGIHTEGLLKVSRMLATITSFDVQPNKAIVGRNAFAHESGIH 335 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK-ESEYNLDNLYDA 359 QDGVLKN YEIMTPES+G + L + SGRAA + ++ +GY+ E L+ + Sbjct: 336 QDGVLKNAATYEIMTPESVGWTRSSLVMGKHSGRAAFRDKLKVLGYEGMDETRLNEAFTR 395 Query: 360 FLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVK 419 F LAD+K V+D D+ AL + + + + R S++S S + ++L+ + Sbjct: 396 FKDLADRKKVVYDDDIIAL--VDDEARDHDRIRFGALSLKSISGQPSEVDLELSVDGKAI 453 Query: 420 AEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVG 479 A GNGPVDA + A+ + + L +S+ A G DA + + G+ G G Sbjct: 454 EAKATGNGPVDAAFNALRKAFPHEARLALFSVGAVTEGTDAQARTTVRLEEAGKMVDGQG 513 Query: 480 LATDIVESSAKAMVHVLNNIW-RAAEVEKE 508 D V S+ +A VH LN + + A E E Sbjct: 514 ADADTVVSAVRAYVHALNKLLVKRARTEPE 543 >UniRef50_UPI0001C31767 2-isopropylmalate synthase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31767 Length = 528 Score = 536 bits (1380), Expect = e-150, Method: Composition-based stats. Identities = 239/505 (47%), Positives = 323/505 (63%), Gaps = 2/505 (0%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 QV+IFDTTLRDGEQ+ SL+ EKL+IA L R+GVD++E GFP++SPGDFE+V+TI Sbjct: 8 PNQVLIFDTTLRDGEQSPGISLNTSEKLEIAQQLARLGVDIVEAGFPIASPGDFEAVETI 67 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 ARQV+ + LAR DID A +L+ A RIHTF++TS +HI ++RST ++VI Sbjct: 68 ARQVEGPVIAGLARIHVGDIDAAWNALRDASRPRIHTFVSTSDIHIEHQMRSTREDVIGL 127 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 V A+ Y DDVEFS DA R+ + A VV+ AI+ GATTINIPDTVGYTMP E+ Sbjct: 128 TRAGVAHAKQYVDDVEFSPMDATRSDVEFTAEVVQIAIDEGATTINIPDTVGYTMPHEYT 187 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 + LYE P + ++SVH HDDLGLAV NS A V AGARQVE A+NG+GERAGN SL Sbjct: 188 AFLGRLYELAPGLRDVVLSVHCHDDLGLAVANSFAGVLAGARQVECAINGLGERAGNASL 247 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EE++M ++ R+ + + T QEI R S+LVS++ + NKAIVG AFAH SGIHQ Sbjct: 248 EEIVMLLRTRQADIGLDTNAVSQEIARASRLVSRMTGYAVQPNKAIVGRNAFAHESGIHQ 307 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 DGVLKNRE +EIM SIGL+ L L SGR A++ + ++G L+ + F Sbjct: 308 DGVLKNRETFEIMDATSIGLDSNSLVLGKHSGRHALRDALAQLGIVVDGATLNTAFKRFK 367 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAE 421 ++ADKK QV DLEAL + +EE + L++F V++ S A V + + +A Sbjct: 368 EIADKKKQVTAMDLEALV-TDELREEIPAYALEWFEVEASSRRPPHARVGVTLPDGSEAT 426 Query: 422 AA-NGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 + G+GP+DAV+ AIN T +L + + A G+DALG+ +V +G G G+ Sbjct: 427 GSFTGDGPIDAVFHAINAATSVEAKLRDFRIDAVTSGQDALGETSVVLEVDGVSGAGQGV 486 Query: 481 ATDIVESSAKAMVHVLNNIWRAAEV 505 +TDI+E++ +A V L+N R V Sbjct: 487 STDIIEAAGRAYVRALSNAVRRRSV 511 >UniRef50_O27525 2-isopropylmalate synthase 2 n=22 Tax=Archaea RepID=LEU12_METTH Length = 505 Score = 531 bits (1368), Expect = e-149, Method: Composition-based stats. Identities = 206/503 (40%), Positives = 294/503 (58%), Gaps = 15/503 (2%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + + V IFDTTLRDGEQ +L+V+EK IA L+ +GVD +E GFP +SPG+ S++ Sbjct: 12 LPENVRIFDTTLRDGEQTPGVALTVEEKTGIARKLDALGVDTIEAGFPAASPGEMNSIRR 71 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I + +C LAR + +DID A + IHTFI TSP+H KL+ + DE+I+ Sbjct: 72 IVELGLEANICGLARVLREDIDAAID----CGVDYIHTFIGTSPLHREYKLKMSPDEIID 127 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 RA++ V+ A + VEFS EDA RT L V AA +AGA IN+PDTVG +P Sbjct: 128 RAVFGVEYAAEHGLKVEFSAEDATRTEFDYLVEVYRAAEDAGAEIINVPDTVGVMIPRAM 187 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 ++S L E + + ISVH H+D GLAV NSLAAV AGA QV +NG+GERAGN + Sbjct: 188 NHLVSRLKEEL----RVPISVHCHNDFGLAVANSLAAVEAGASQVHATVNGLGERAGNAA 243 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV+MA+ R D+ I E+ S+ VS+I + +P NKAIVG AFAH +GIH Sbjct: 244 LEEVVMALITRYDLP---VDIRTVELVNISEFVSKITGVRMPPNKAIVGENAFAHEAGIH 300 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 GVL+ E YE +TPE +G + ++ L +G A++ ++ E G + E LY+ Sbjct: 301 VHGVLEKAETYEPITPEMVGHKR-RIVLGKHTGANALRSKLQEYGIEMKEEQFCTLYEQV 359 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 +L DK ++ D DL A+A + E +L+ +V +G + + TA VKL G+EVK Sbjct: 360 KRLGDKGKRITDADLRAMAVTILGKASREIVKLEGIAVMTGESVMPTATVKLRIGDEVKT 419 Query: 421 EAANGNGPVDAVYQAINRITEY--NVELVKYSLTAKGHGKDALGQVDIVANYN-GRRFHG 477 + G GPVDA AI + ++EL +Y++ A G +AL +V +V + G + G Sbjct: 420 TSMTGVGPVDAAINAIQSLVSETADIELDEYNIEAITGGTNALAEVFVVMSDGEGNKATG 479 Query: 478 VGLATDIVESSAKAMVHVLNNIW 500 DIV +S +A++ +N I Sbjct: 480 RSTREDIVMASVEAVLDAINKIL 502 >UniRef50_C0Z635 Probable 2-isopropylmalate synthase n=1 Tax=Brevibacillus brevis NBRC 100599 RepID=C0Z635_BREBN Length = 514 Score = 525 bits (1352), Expect = e-147, Method: Composition-based stats. Identities = 214/508 (42%), Positives = 309/508 (60%), Gaps = 3/508 (0%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M++++ IFDTTLRDGEQA ASLS ++K+ IA L +GVDV+E GFP+SSPGDF +VQ Sbjct: 1 MTKRIHIFDTTLRDGEQAPGASLSPEQKIVIAKHLADLGVDVIEPGFPISSPGDFMAVQR 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I+++V +C AR V++DID A + + AE R+H F+++S +H+ +LR + ++VI+ Sbjct: 61 ISQEVHGVEICGFARAVKEDIDAAVRATQAAERRRLHMFLSSSSIHLDFQLRKSREQVIK 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 A M+ + + D EFS DA RT L ++EAAI GAT INIPDTVGY +P E+ Sbjct: 121 IAREMIAYGKQFVDRFEFSPMDATRTGDEFLFEMIEAAIEEGATIINIPDTVGYALPEEY 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 + + + + V DK S H H+DLGLAV NSLAA+ AG QVE +NG+GERAGNCS Sbjct: 181 GAMFTRVMKNVRGSDKVEFSAHCHNDLGLAVANSLAAIRAGVTQVEVTVNGVGERAGNCS 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEE++MAI+ RK+ L+ T I + I+ TSQ VS+ + PI NK IVG AF H +GIH Sbjct: 241 LEELVMAIETRKEALDAETRIRPEHIYTTSQKVSRAMSFPIAFNKPIVGRNAFQHEAGIH 300 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 QDG+LK R YEIM PES+G+ + + L SGR A+KHR++E G + ++ ++ LY F Sbjct: 301 QDGLLKERSTYEIMDPESLGVPRNMIILGKHSGRHAIKHRVNEFGIQLTDEQMEALYVQF 360 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKL--ACGEEV 418 +LADK+ V D+ L L E F L V +G++ A+ + E Sbjct: 361 KELADKQKVVQDHQLLELVGH-TVNAVLEPFTLVNAQVLTGTSGHRMASCTIMNNVTGEE 419 Query: 419 KAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGV 478 +A + G GPV+A+ I + ++VE L + G+ A G+ + + NG F GV Sbjct: 420 QAYSGTGEGPVEALVAGIKQALPFDVEFTDMELYSLSSGEHATGEAIVTVSANGSHFKGV 479 Query: 479 GLATDIVESSAKAMVHVLNNIWRAAEVE 506 D++ + A+A + N R + + Sbjct: 480 AEHRDVLMAVAQAFMAASNQAVRDHQAK 507 >UniRef50_A2C859 2-isopropylmalate synthase n=16 Tax=Bacteria RepID=LEU1_PROM3 Length = 540 Score = 524 bits (1351), Expect = e-147, Method: Composition-based stats. Identities = 245/515 (47%), Positives = 331/515 (64%), Gaps = 16/515 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 +V+IFDTTLRDGEQ+ ASL+++EKL IA L R+GVDV+E GFP +S GDF +VQ I Sbjct: 5 PGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDVIEAGFPFASQGDFSAVQRI 64 Query: 62 ARQV---KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEV 118 A+QV + +C LAR DI A+++ A RIHTFIATS +H+ KLR + EV Sbjct: 65 AQQVGGDEGPIICGLARASRADIKACADAVAPAPRRRIHTFIATSDIHLEHKLRKSRAEV 124 Query: 119 IERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 + MV AR+ DDVEFSCEDA R+ L V+EAAI AGA TINIPDTVG+T P Sbjct: 125 LAIVPEMVAYARSLVDDVEFSCEDAARSDPEFLYEVIEAAIAAGAGTINIPDTVGFTTPS 184 Query: 179 EFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGN 238 EF +I+G+ VPN+++AI+SVH H+DLGLAV N L AV +GARQ E +NGIGERAGN Sbjct: 185 EFGALIAGIDCHVPNMNEAILSVHGHNDLGLAVANFLEAVKSGARQFECTINGIGERAGN 244 Query: 239 CSLEEVIMAIKVRK-----------DILNVHTAINHQEIWRTSQLVSQICNMPIPANKAI 287 +LEE++MA+ VR+ D TA+ +EI +TS+LVS + M + NKAI Sbjct: 245 AALEELVMALYVRRRYFNPFFGRESDSPTPLTAVRTEEITKTSRLVSNLTGMVVQPNKAI 304 Query: 288 VGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK 347 VGS AFAH SGIHQDGVLKNR YEI+ ++GL +++L SGR+AV+ R++E+GY Sbjct: 305 VGSNAFAHESGIHQDGVLKNRLTYEIVDARTVGLTDNRISLGKLSGRSAVRARLEELGYD 364 Query: 348 ESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIAT 407 + +LD + F LAD+K + D DLEA+ + Q+ F+L V GS+ T Sbjct: 365 LTREDLDEAFARFKDLADRKRDITDRDLEAIVSE-QVQQPEARFQLRLVQVSCGSSLRPT 423 Query: 408 AAVKLAC-GEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDI 466 A V LA + + AA G GPVDAV +A+N + EL+++S+ + G DA+G+V I Sbjct: 424 ATVILAQEDGQEQTAAAVGTGPVDAVCRALNALAGEPNELIEFSVKSVTEGIDAMGEVTI 483 Query: 467 VANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWR 501 +G+ F G TD+V ++A+A V+ LN + Sbjct: 484 RLRRDGQLFSGHSADTDVVVAAAQAFVNALNRLVA 518 >UniRef50_B4SI67 2-isopropylmalate synthase n=45 Tax=Xanthomonadaceae RepID=LEU1_STRM5 Length = 528 Score = 524 bits (1349), Expect = e-147, Method: Composition-based stats. Identities = 219/511 (42%), Positives = 312/511 (61%), Gaps = 10/511 (1%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 + ++ IFDTTLRDGEQ+ S+S +KL +A AL+ +GVD++E GFP SS D +++ I Sbjct: 9 TPRIRIFDTTLRDGEQSPGCSMSPPQKLVMARALDELGVDIIETGFPASSQSDRDAMALI 68 Query: 62 ARQVKNSRVC--ALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 R+++ + L+RC++ DI+ +A +L+ A R+H F++TSP+H KLR T ++V+ Sbjct: 69 GRELRRPSLSLAVLSRCLQADIETSARALEAAANPRLHVFLSTSPLHREHKLRMTREQVL 128 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE 179 E V AR+Y DDVEFS EDA RT + L V AAI+AGATTIN+PDTVG+T P E Sbjct: 129 ESVRKHVSLARSYIDDVEFSAEDATRTELDYLIEVSRAAISAGATTINLPDTVGFTTPEE 188 Query: 180 FAGIISGL---YERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERA 236 + + VPN I S H H+DLGLAV NSLAA+ GARQVE +NGIGERA Sbjct: 189 IREMFQQVIAGVADVPNAANVIFSAHCHNDLGLAVANSLAAIEGGARQVECTVNGIGERA 248 Query: 237 GNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHS 296 GNCSLEE+ M +KVR+ ++IN I TSQL+ ++ MP+ NKAIVG+ AFAH Sbjct: 249 GNCSLEEIAMVLKVRQAFYEQDSSINTPRIVGTSQLLQRLVGMPVQRNKAIVGANAFAHE 308 Query: 297 SGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNL 356 SGIHQ G+L++R YEIM PE +G Q+ L SGRAAV+ R+ +G+ E L + Sbjct: 309 SGIHQHGMLRHRGTYEIMRPEDVGWEDSQMVLGRHSGRAAVEARLRALGFWLEEDELKLV 368 Query: 357 YDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLAC-G 415 ++ F L +++ V D DL+ L G + +RL ++ S A A V+L+ Sbjct: 369 FEQFKGLCEQQRVVTDADLQTLMQGGSNA---QGYRLASMTI-SDVGSRANALVELSDPD 424 Query: 416 EEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRF 475 AE A G+GPVDA++ A++ T + L Y + + G G DA G+ ++ + G + Sbjct: 425 GNRVAETAQGDGPVDALFGALSAATGVQLMLDSYHVHSVGIGADARGEANLSVRHEGVEY 484 Query: 476 HGVGLATDIVESSAKAMVHVLNNIWRAAEVE 506 G G + DI+E+SA A + V N + R + Sbjct: 485 DGTGTSKDIIEASALAWLDVANRLLRQRQAN 515 >UniRef50_Q58787 (R)-citramalate synthase n=5 Tax=Methanococcales RepID=CIMA_METJA Length = 491 Score = 522 bits (1345), Expect = e-146, Method: Composition-based stats. Identities = 182/500 (36%), Positives = 276/500 (55%), Gaps = 16/500 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V IFDTTLRDGEQ SL+ +KL+IA L+ +GVDV+E G ++S G+ E ++ I ++ Sbjct: 3 VRIFDTTLRDGEQTPGVSLTPNDKLEIAKKLDELGVDVIEAGSAITSKGEREGIKLITKE 62 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 N+ +C+ R + DID A E + +H + TSP+H+ KLR T DEV+E A+ Sbjct: 63 GLNAEICSFVRALPVDIDAALE----CDVDSVHLVVPTSPIHMKYKLRKTEDEVLETALK 118 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 V+ A+ + VE S EDA R+ + L ++ GA + + DTVG P + + Sbjct: 119 AVEYAKEHGLIVELSAEDATRSDVNFLIKLFNEGEKVGADRVCVCDTVGVLTPQKSQELF 178 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + E V +SVH H+D G+A N+ +AV GA Q +NGIGERAGN SLEEV Sbjct: 179 KKITENV----NLPVSVHCHNDFGMATANTCSAVLGGAVQCHVTVNGIGERAGNASLEEV 234 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 + A+K+ T I ++++ S++VS++ +P+P NKAIVG AFAH +GIH DG+ Sbjct: 235 VAALKILYG---YDTKIKMEKLYEVSRIVSRLMKLPVPPNKAIVGDNAFAHEAGIHVDGL 291 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 +KN E YE + PE +G N+ ++ L SGR A+K+++D MG S+ L+ +Y+ + Sbjct: 292 IKNTETYEPIKPEMVG-NRRRIILGKHSGRKALKYKLDLMGINVSDEQLNKIYERVKEFG 350 Query: 365 DKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEE--VKAEA 422 D + D DL A+ + E +LD +V SG+ A+VKL E E Sbjct: 351 DLGKYISDADLLAIVREVTGKLVEEKIKLDELTVVSGNKITPIASVKLHYKGEDITLIET 410 Query: 423 ANGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 A G GPVDA A+ + +++LV+Y + A G G DAL +V + Sbjct: 411 AYGVGPVDAAINAVRKAISGVADIKLVEYRVEAIGGGTDALIEVVVKLRKGTEIVEVRKS 470 Query: 481 ATDIVESSAKAMVHVLNNIW 500 DI+ +S A++ +N + Sbjct: 471 DADIIRASVDAVMEGINMLL 490 >UniRef50_Q9LPR4 2-isopropylmalate synthase 1, chloroplastic n=39 Tax=cellular organisms RepID=LEU11_ARATH Length = 675 Score = 520 bits (1340), Expect = e-146, Method: Composition-based stats. Identities = 230/577 (39%), Positives = 323/577 (55%), Gaps = 76/577 (13%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 V +FDTTLRDGEQ+ A+L+ KEKL IA L ++GVD++E GFP +S DFE+V+TI Sbjct: 86 PNYVRVFDTTLRDGEQSPGATLTSKEKLDIARQLAKLGVDIIEAGFPAASKDDFEAVKTI 145 Query: 62 ARQVKN--------SRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRS 113 A V N +C L+RC +KDI+ A +++K A+ RIHTFIATS +H+ KL+ Sbjct: 146 AETVGNTVDENGYVPVICGLSRCNKKDIERAWDAVKYAKRPRIHTFIATSDIHLEYKLKK 205 Query: 114 TLDEVIERAIYMVKRARNYT-DDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTV 172 T EVIE A MV+ AR+ +DVEFS EDAGR+ L ++ I AGATT+NIPDTV Sbjct: 206 TKAEVIEIARSMVRFARSLGCEDVEFSPEDAGRSEREYLYEILGEVIKAGATTLNIPDTV 265 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G T+P EF +I+ L P I+ +IS H +DLGL+ N+L+ HAGARQ+E +NGI Sbjct: 266 GITLPSEFGQLITDLKANTPGIENVVISTHCQNDLGLSTANTLSGAHAGARQMEVTINGI 325 Query: 233 GERAGNCSLEEVIMAIKVRKD--ILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGS 290 GERAGN SLEEV+MAIK R D + + T I+ + I TS++V + M +KAIVG+ Sbjct: 326 GERAGNASLEEVVMAIKCRGDHVLGGLFTGIDTRHIVMTSKMVEEYTGMQTQPHKAIVGA 385 Query: 291 GAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQ---IQLNLTSRSGRAAVKHRMDE---- 343 AFAH SGIHQDG+LK++ YEI+ PE IGL + + L SGR A+K R+ E Sbjct: 386 NAFAHESGIHQDGMLKHKGTYEIICPEEIGLERSNDAGIVLGKLSGRHALKDRLTEVHSN 445 Query: 344 -------------------------MGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEAL 378 +GY+ + L ++ F +A++K +V D D+ AL Sbjct: 446 LTHTNTCIAIFVGDTNVLLSFVHFQLGYQLDDEQLSTIFWRFKTVAEQKKRVTDADIIAL 505 Query: 379 AFIGKQQEEPEH-FRLDYFSVQSGSNDIATAAVKLACGEEVKAEAAN-GNGPVDAVYQAI 436 + + +PE ++L + G+ ++TA VKLA + + A + G GPVD+ Y+A+ Sbjct: 506 --VSDEVFQPEAVWKLLDIQITCGTLGLSTATVKLADADGKEHVACSIGTGPVDSAYKAV 563 Query: 437 NRITEY---------------NVELVKYSLTAKGHGKDALGQVDIVANYNG--------- 472 + I + L++YS+ A G DA+ ++ + Sbjct: 564 DLIVKVLFIPLRLSSTNNSPEPATLLEYSMNAVTEGIDAIATTRVLIRGSNKYSSTNAIT 623 Query: 473 -----RRFHGVGLATDIVESSAKAMVHVLNNIWRAAE 504 R F G G DIV SS KA V LN + E Sbjct: 624 GEEVQRTFSGTGAGMDIVVSSVKAYVGALNKMMDFKE 660 >UniRef50_Q2S0M7 2-isopropylmalate synthase n=3 Tax=Bacteria RepID=Q2S0M7_SALRD Length = 546 Score = 519 bits (1337), Expect = e-145, Method: Composition-based stats. Identities = 233/534 (43%), Positives = 315/534 (58%), Gaps = 24/534 (4%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 MS + IFDTTLRDGEQA AS++V EK+ IA L + VDV+E GFP+SSP E+V Sbjct: 1 MSDSITIFDTTLRDGEQAPGASMTVPEKVHIAHKLADLNVDVIEAGFPISSPAQTEAVTR 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRS------- 113 IA +V CALAR E DID A E+L R+HTFIATS +HI K Sbjct: 61 IATEVDGPVTCALARTKEDDIDAAGEALADGTDTRLHTFIATSDVHIEAKFDKLGNTMAE 120 Query: 114 TLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVG 173 + +I+RA+ +++A YTD+VEFS EDAGRT L VV+AA AGATTINIPDT G Sbjct: 121 KREAIIQRAVRAIEQALTYTDNVEFSAEDAGRTDPEFLCEVVQAAAEAGATTINIPDTTG 180 Query: 174 YTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIG 233 Y P E+ ++ + + +P+ D +S H HDDLGLA N+LA + AGARQVE +NGIG Sbjct: 181 YCAPSEYTDLLETVVDCLPDPDAVTLSTHCHDDLGLATANTLAGIRAGARQVECTINGIG 240 Query: 234 ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAF 293 ERAGN +LEE++MA+ VR D +V ++ + + TSQ VS P+ NKAIVGS AF Sbjct: 241 ERAGNAALEEIVMALTVRADAFDVTADVHTEHLTPTSQTVSAATGFPVQPNKAIVGSNAF 300 Query: 294 AHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNL 353 +H +GIHQ GVL+ R YEIM+ +G + Q+ L SGR + +R++ MGY E + Sbjct: 301 SHEAGIHQHGVLEERTTYEIMSATDVGQDAEQIRLGRHSGRHGLFNRLEAMGYAVPEGHR 360 Query: 354 DNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEE----------------PEHFRLDYFS 397 D LYD FL LAD+K +VF+ DLE + +RLD FS Sbjct: 361 DALYDRFLDLADRKKEVFEEDLEQMMNDFGGDAVAAATGLPDNGVALNGGTPAYRLDQFS 420 Query: 398 VQSGSNDIATAAVKL-ACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGH 456 V S+D A +V+L + E A G GPVDA+Y+A++ + LV YS+ + Sbjct: 421 VHLSSDDEAKVSVRLQRDDGSAREEQATGEGPVDALYRALDHAVDAPHTLVDYSIRSISE 480 Query: 457 GKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQ 510 G DA G+V++ Y +F G TD++ +SA+A V LN + A E + ++ Sbjct: 481 GADAQGEVEVTIRYGENQFAGTARNTDVIRASAEAYVDALNRLVAAQEHAESVE 534 >UniRef50_A9KRN2 2-isopropylmalate synthase n=8 Tax=Bacteria RepID=A9KRN2_CLOPH Length = 505 Score = 514 bits (1324), Expect = e-144, Method: Composition-based stats. Identities = 208/502 (41%), Positives = 321/502 (63%), Gaps = 5/502 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ +FDTTLRDGEQ A L+ +EK+ IA LE++ VD ME GFP SS GDFE+V+ I+ Sbjct: 2 RKIYVFDTTLRDGEQVPGAKLNFEEKMYIAKQLEKLRVDYMEAGFPSSSQGDFEAVREIS 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 RQ+K+S V AL R V+ DID ESLK A IH + +S +HI K +++++ Sbjct: 62 RQIKDSSVVALGRAVKSDIDRMYESLKEAANPMIHIVLGSSNVHITKKFNKNPEDILQMG 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + V A+ YT VE+S EDA R+ + + R +EA + AGAT +NIPDTVG+ +P F G Sbjct: 122 VDAVTYAKRYTSQVEYSLEDASRSDLEYMWRTIEAVVKAGATCVNIPDTVGFAVPELFGG 181 Query: 183 IISGLYERVPNI-DKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 +I +Y+R+ N+ ++SVH H+D GLA N+LAAV GA +VE +NGIGERAGN SL Sbjct: 182 LIHQIYDRLQNVAPHVLLSVHCHNDSGLATANTLAAVRNGANKVECTINGIGERAGNTSL 241 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EEV+M IK+ + + +T INH I+ TS++VS+ + + NKA+VG AFAHSSGIHQ Sbjct: 242 EEVVMGIKLHPEYYDGYTDINHSAIYETSRIVSRTMGLDVQVNKALVGENAFAHSSGIHQ 301 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 DG+LK++E YEI P IG + + LT+RSG+ A ++ ++GY+ + L+ ++ FL Sbjct: 302 DGLLKSKEVYEIFEPSDIGAPPMDIVLTARSGKHAFEYISKKLGYEIAPEVLNEIHANFL 361 Query: 362 KLADKKGQVFDYDLEALAFIGKQQE---EPEHFRLDYFSVQSGSNDIATAAVKLACGEEV 418 K+AD+K +V+D D+ L ++ + E + + L+ F + + ++ +A VKL ++ Sbjct: 362 KIADEKKEVYDNDVIDLLDGDERVQKNGEKKLWMLEDFQINV-NMNLPSATVKLVRNKQE 420 Query: 419 KAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGV 478 + GNG + A+Y AI + + + L+ Y + G K++LG+V + YNG+ + G Sbjct: 421 AVVSEAGNGAISALYAAILKAVDMPIHLIDYRIQNIGAEKESLGKVVVQIQYNGKFYFGK 480 Query: 479 GLATDIVESSAKAMVHVLNNIW 500 + D++++SA A+V+ +N I Sbjct: 481 AIERDVMKASALALVNSVNKIV 502 >UniRef50_D2RHN2 Isopropylmalate/citramalate/homocitratesynthase n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RHN2_ARCPR Length = 498 Score = 511 bits (1316), Expect = e-143, Method: Composition-based stats. Identities = 182/510 (35%), Positives = 282/510 (55%), Gaps = 18/510 (3%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + + +FDTTLRDGEQ SL V K+QIA L+++GVDV+E GFP +S G+FE+V+ IA Sbjct: 2 RTIKVFDTTLRDGEQMPGVSLPVNYKIQIAKQLDKLGVDVIEAGFPSASKGEFEAVKEIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 N+++C LAR V+KDID A + A+ +H FI TS + + ++ T DE+++ + Sbjct: 62 NLGLNAKICGLARVVKKDIDQAIK----ADVDIVHVFIPTSKIQVEHTIKKTPDEIVQLS 117 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + V+ +++ + FS DA RT + L R+ +A AG IN+PDTVG PF F Sbjct: 118 VDAVEYVKSHGVECMFSAMDATRTEMDFLKRIYKAVEEAGVDIINVPDTVGIATPFRFYD 177 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 +I L E + I VH H+D GLA N+ AAV AGA +V+ +NG+GERAGN LE Sbjct: 178 MIKKLKEHL----NVPIDVHCHNDFGLATANTYAAVLAGADEVQVTVNGLGERAGNAPLE 233 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV+ + T I + + TS+LV ++ + +P NK IVG AF+H SGIH Sbjct: 234 EVVALLYAEG----FKTNIRMEYLVETSRLVERLTGVKMPPNKPIVGENAFSHESGIHAH 289 Query: 303 GVLKNRENYEI--MTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 GVLK+ +E +TPE +G + ++ + +GR +K +++ GY + L + Sbjct: 290 GVLKDARTFEPGIITPEMVGHKR-RIVVGKHAGRHQIKKILEDAGYVVDDEKLSIIVQKV 348 Query: 361 LKLADKKGQVFDYDLEALA--FIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEV 418 +L DK +V D DL A+A +G+ E+ +D +V +G+ TA + E Sbjct: 349 KELGDKGKKVTDLDLFAIAESVLGEVSEKDRIINVDEVTVLTGNKITPTAVINAEVEGER 408 Query: 419 KAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANY-NGRRFHG 477 K +A G GPVDA ++A+ + +++ ++ L A G DAL V + +G F Sbjct: 409 KVTSAIGVGPVDATFKAVTELLGRKIKITEFRLDAITGGSDALANVYVTVEDEDGETFTA 468 Query: 478 VGLATDIVESSAKAMVHVLNNIWRAAEVEK 507 DIV +S A++ +N + + +K Sbjct: 469 RSAGADIVMASFDAVIKAVNYLMLKKKRKK 498 >UniRef50_Q1ARE2 2-isopropylmalate synthase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1ARE2_RUBXD Length = 510 Score = 509 bits (1310), Expect = e-142, Method: Composition-based stats. Identities = 225/485 (46%), Positives = 306/485 (63%), Gaps = 2/485 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ IFDTTLRDGEQ+ SLSV+EK++IA L R+ VDV+E GFP++S GDFE+V IA Sbjct: 2 RRIQIFDTTLRDGEQSPGISLSVEEKVEIAHQLARLKVDVIEAGFPITSEGDFEAVSRIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 +V+ + LAR ++DI+ A E+++ + RIHTF+ TS +HI ++RST +E++ A Sbjct: 62 SEVEGPVIAGLARIHQEDIERAWEAVRWSRRPRIHTFVGTSDLHIEHQMRSTREEILSGA 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 V+ A++ ++VEFS DA RT I LA VV AA+ AGA INI DTVGYT P EFA Sbjct: 122 AEAVRLAKSLCENVEFSPMDATRTDIGYLAEVVAAAVEAGADVINIADTVGYTTPAEFAA 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + L ERVP + + ++SVH HDDLG+AV NSLA V AGA QVE A+NGIGERAGN SLE Sbjct: 182 FLRELKERVPGLAERVLSVHCHDDLGMAVANSLAGVEAGATQVEVAVNGIGERAGNASLE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV+MA+ RKD V + +++ TS++VS + +P NKA+VG AF H SGIHQD Sbjct: 242 EVVMALVTRKDYYGVEVGVETRQLANTSRMVSNMTGYDVPPNKAVVGRNAFLHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 GVLK+R +EIM P IGL + L SGR A+K + ++GY L + F + Sbjct: 302 GVLKDRRTFEIMKPADIGLEGTNIFLGKHSGRHALKEALADLGYTLEGETLKRAFKRFKE 361 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEE-VKAE 421 LAD K V DLEA+A E + F L+ F V + + + AAV++A + Sbjct: 362 LADHKKTVTAADLEAIAADEVGSFEGK-FVLESFRVVAATGRQSRAAVRIAHADRGTFEA 420 Query: 422 AANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLA 481 A G GPVDAV++AI+ T L + + A GKDALG+V + + G G GL+ Sbjct: 421 EAEGEGPVDAVFRAIDSATGIKGRLTDFRIDAVTGGKDALGEVRVTVEFEGTECAGRGLS 480 Query: 482 TDIVE 486 D+VE Sbjct: 481 QDVVE 485 >UniRef50_UPI0001C41E20 2-isopropylmalate synthase LeuA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41E20 Length = 511 Score = 504 bits (1298), Expect = e-141, Method: Composition-based stats. Identities = 182/507 (35%), Positives = 288/507 (56%), Gaps = 15/507 (2%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + ++ IFDTTLRDGEQA +L+V EK++IA L+ +GV+V+E+GFP S G+ ++ + Sbjct: 15 IPDEIKIFDTTLRDGEQAPGIALTVDEKIKIAQRLDELGVNVIEMGFPTVSSGERKAARE 74 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 + +S +C LAR V+KDID +S + H FI TSP+H KL+ + E++ Sbjct: 75 MVSLGFSSELCGLARVVQKDIDALIDS----DLSYAHLFIGTSPLHRDYKLKKSKTEILS 130 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 +++ MV+ A+++ VEFS EDA RT + L + +AGA IN+PDTVG +P Sbjct: 131 QSMEMVEYAKDHGLKVEFSAEDATRTELNYLIEFYKGVESAGADIINVPDTVGILVPSTT 190 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 +I L +++ IS+H H+D GLAV NSL + GA Q +NGIGERAGN S Sbjct: 191 RTLIRTLRKKI----NLPISLHFHNDFGLAVSNSLIGIEEGANQAHCTINGIGERAGNTS 246 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEE+++++K+ + ++ +++ TS + I + +P K IVG AFAH SGIH Sbjct: 247 LEELVVSLKIAYG---ANLTVDTTKLYDTSNFIGSITGIKMPPTKPIVGDNAFAHESGIH 303 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 DG+LKN YE + PE +G + ++ L +G AA+K +++E + ++ DN+Y+ Sbjct: 304 VDGILKNSSTYEPIAPEIVGHKR-RIALGKHTGHAAIKSKLEEFNIEVTQKQFDNIYNQV 362 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 L DK + D DL ++A E+ +L SV +G + ATA +KL+ ++ Sbjct: 363 KTLGDKGKCLTDDDLRSIAITEIGTSGKEYIKLLGLSVMTGESVSATATIKLSIDGKIME 422 Query: 421 EAANGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKDALGQVDIVANYN-GRRFHG 477 + G GPVDA A+ + + N+ L +Y L A G DAL + +V + + G + G Sbjct: 423 TSQIGVGPVDASVLALKTLVQDRVNISLDEYRLEAITGGTDALAETFVVISDDKGNKATG 482 Query: 478 VGLATDIVESSAKAMVHVLNNIWRAAE 504 D++ SS A+++ +N I E Sbjct: 483 RATREDVILSSVIAVINSINRILDIQE 509 >UniRef50_O26819 (R)-citramalate synthase n=20 Tax=Archaea RepID=CIMA_METTH Length = 496 Score = 504 bits (1298), Expect = e-141, Method: Composition-based stats. Identities = 187/505 (37%), Positives = 275/505 (54%), Gaps = 15/505 (2%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 QV + DTTLRDGEQ SL+ +EKL+IAL ++ +G D++E G ++S G+ E ++ I Sbjct: 2 QVRVLDTTLRDGEQTPGVSLTPEEKLRIALKIDALGADIIEAGSAITSEGEREGIRKITS 61 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 + + +C+ AR V +DID A + +H + TS +H+ KLR T +EV+E+A+ Sbjct: 62 EGLRAEICSFARAVREDIDAAI----SCDVDSVHLVVPTSDLHLEHKLRKTREEVLEQAV 117 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 + A ++ VE S ED+ R+ + L + I AGA I DTVG P Sbjct: 118 DCTEYAVDHGILVELSAEDSTRSDMDFLRTIFREGIEAGAERICACDTVGILTPERSYEF 177 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 GL E A +SVH H+D GLAV NSLA + AGA +V +NGIGERAGN +LEE Sbjct: 178 YRGLSEL-----GAPLSVHCHNDFGLAVANSLAGLRAGASEVHATINGIGERAGNAALEE 232 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 V++A+K D V T+IN + ++ TS++V+++ + + NKAIVG AFAH SGIH DG Sbjct: 233 VVVALKSLYD---VDTSINIEMLYETSRMVARMTGVYLQPNKAIVGENAFAHESGIHADG 289 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 VLK E YE +TPE +G + + G A++ R+DE+G K ++ L ++ L Sbjct: 290 VLKKAETYEPITPEMVGHGR-GFVMGKHIGTHALRKRLDELGMKVADDKLMEIFRRVKTL 348 Query: 364 ADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAA 423 D V D DL+A+A E + L ++ SG+ TA+VKL + EA Sbjct: 349 GDMGKCVTDVDLQAIAEDVLGVMEDKVVDLQEVTIVSGNRVTPTASVKLRVDDREVLEAG 408 Query: 424 NGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLA 481 G GPVDA AI + E ++ L +Y + A G DAL V I + R Sbjct: 409 TGVGPVDAAIVAIKKSLEDFADITLEEYHVDAITGGTDALIDVVIKLRHGDRIISARSTQ 468 Query: 482 TDIVESSAKAMVHVLNNIWRAAEVE 506 DI+ +S +A + +N + + E Sbjct: 469 PDIIMASVEAFLSGVNRLLANEKSE 493 >UniRef50_P58968 2-isopropylmalate synthase 2 n=19 Tax=Archaea RepID=LEU12_METMA Length = 516 Score = 504 bits (1297), Expect = e-141, Method: Composition-based stats. Identities = 187/509 (36%), Positives = 276/509 (54%), Gaps = 19/509 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 S++V +FDTTLRDGEQ SL+ +KL+IA L+++GVD++E GFP+SS GD ESV++I Sbjct: 17 SKKVTVFDTTLRDGEQTPGVSLTSTQKLEIAHQLDKLGVDIIEAGFPISSEGDKESVKSI 76 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 + ++ VC LAR ++KDID ES + +HTF+ TS + ++ + +EVI+ Sbjct: 77 SNAGLDTTVCGLARVLKKDIDACFES----DVGLVHTFVPTSDVQRIYTIKKSREEVIQL 132 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 A+ V+ +++ FS DA RT L V +A AG IN+PDTVG +P Sbjct: 133 AVEAVQYIKDHGLKCMFSAMDATRTDPEYLIEVFKAVQEAGCDIINVPDTVGVMVPSAMY 192 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 I G+ + I VH H+D GLAV NSL AV AGA QV+ +NGIGERAGN L Sbjct: 193 RQIKGIAAEIT----IPIDVHCHNDFGLAVANSLMAVEAGASQVQVTINGIGERAGNADL 248 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 + +M++ I T I + + TS++V + +P N +VG AF+H SGIH Sbjct: 249 SQTVMSL---TSIYGAKTNIRTEYLVETSKMVENYTGIRLPPNTPVVGQNAFSHESGIHS 305 Query: 302 DGVLKNRENYEI--MTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 GVL+ + +E MTPE +G + ++ L +G+ AVK ++ G K ++ LD + Sbjct: 306 QGVLEKSDTFEPGIMTPEMVGHRR-RIVLGKHTGKHAVKQSLESAGIKTNDNQLDEIVIR 364 Query: 360 FLKLADKKGQVFDYDLEAL--AFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEE 417 ++A+K Q+ D DL A+ A +GK E E +L SV +G+ TA VK + Sbjct: 365 IKEIANKGKQITDADLYAVASAVLGKASSEEELIKLKEVSVMTGNILTPTAVVKADIEGK 424 Query: 418 VKAEAANGNGPVDAVYQAINRITEY--NVELVKYSLTAKGHGKDALGQVDIVAN-YNGRR 474 A G GPVDA A+ I + L + + A G DAL V I GR Sbjct: 425 EIIAARTGVGPVDAALHAVRDILGESNHFRLQDFRIDAITGGADALADVYIGLENEKGRI 484 Query: 475 FHGVGLATDIVESSAKAMVHVLNNIWRAA 503 DIV +S +A+V+ +N +++ Sbjct: 485 VTARSANPDIVMASVEALVNAMNLLYKKE 513 >UniRef50_UPI0001C42034 citramalate synthase CimA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C42034 Length = 497 Score = 500 bits (1288), Expect = e-140, Method: Composition-based stats. Identities = 166/503 (33%), Positives = 275/503 (54%), Gaps = 16/503 (3%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 ++ + DTTLRDGEQ SL+ +KL+IA L+ +GV+ +E G ++S G+ E+++ I Sbjct: 2 KIEVLDTTLRDGEQTPGISLNTIKKLRIATKLDEIGVNSIEAGSAITSEGEREAIKAITS 61 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 Q N+ + + +R + KD+D E + ++ + TS +H+ KL+ T DE++E A+ Sbjct: 62 QGLNAEIVSFSRTLIKDVDYCLE----CDVDAVNIVVPTSDLHLQYKLKKTQDEMLEDAV 117 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 + + A+++ VE + ED+ RT I L ++ +A I+AGA I DT+G P + Sbjct: 118 KVTEYAKDHGVKVELAAEDSTRTDIQYLRKIFKATIDAGADRICPCDTLGILTPLKSFNF 177 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 + +S H H+D GLAV N+L+A+ GA + +NG+GERAGN +LEE Sbjct: 178 YKQFTDL-----GVPVSAHCHNDFGLAVANTLSAIDGGASRFHATINGLGERAGNAALEE 232 Query: 244 VIMAIKV----RKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 V++++ + T I +I+ TS+LVS++ N + NK IVG AFAH SGI Sbjct: 233 VVVSLYTLYKDESNERKYETDIKIDQIYSTSKLVSRLSNAYLAPNKPIVGENAFAHESGI 292 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 H DGV+KN YE + PE +G + + + G + +R++E+G + ++ L++++ Sbjct: 293 HADGVIKNSATYEPIMPELVGHRR-KFVIGKHVGTKGLNNRLEELGLEVNKKQLNDIFYK 351 Query: 360 FLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVK 419 L DK V D DLEA+A E+ + LD ++ SG+ TA++KL E Sbjct: 352 VKDLGDKGKTVTDTDLEAIAEHVLNIEQEKKINLDELTIVSGNKIRPTASIKLNIENEEV 411 Query: 420 AEAANGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHG 477 EA G GPVDA A+N+ + +++L +Y + A G DAL +V I + + Sbjct: 412 IEADVGIGPVDAAINAVNKGIKSFADIQLEEYHVDAVTGGTDALIEVIIKLSSGDKIISA 471 Query: 478 VGLATDIVESSAKAMVHVLNNIW 500 DI+ +S +A + +N + Sbjct: 472 RATEPDIINASVEAYIDGVNRLL 494 >UniRef50_C6CVJ5 2-isopropylmalate synthase n=2 Tax=Bacillales RepID=C6CVJ5_PAESJ Length = 513 Score = 498 bits (1282), Expect = e-139, Method: Composition-based stats. Identities = 197/485 (40%), Positives = 304/485 (62%), Gaps = 3/485 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ IFDTTLRDGEQ+ AS+ + K+ IA L ++GVD++E GF +SSPG+F ++Q I+ Sbjct: 2 KKIQIFDTTLRDGEQSPGASIEPERKIIIARQLAKLGVDIIEPGFAISSPGEFAAIQQIS 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 R+++N +C AR V+ DID A ++ + A R+H FI++S +H++ ++R T EV++ A Sbjct: 62 RELQNVEICGFARAVKVDIDAAVKATQDAAKRRLHLFISSSDIHLSHQIRKTRSEVVQIA 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 M+ A+ + D+++F+ D+ R+ + +VEAAI +GAT IN+PDT+GY +P E Sbjct: 122 RDMISYAKQFVDEIQFAAMDSTRSDRDFVIELVEAAIESGATIINLPDTLGYALPNEMVD 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + + + ++ DK S H H+DLG+AV NSLAAV AGA QVE +NG+GERAGNCSLE Sbjct: 182 LFTSVRQQARGGDKVRYSTHNHNDLGMAVANSLAAVQAGATQVEVTVNGVGERAGNCSLE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E+ M I+ RK L + T I EI+ TS +VS+ + PI NK IVG AF H SGIHQD Sbjct: 242 ELAMLIETRKSALEIETNIEQSEIYTTSHMVSRAMHYPIAYNKPIVGRNAFQHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G+LK+R YEIM PE++G+++ + L SGR A+KHR+ E G ++ L+++YD F + Sbjct: 302 GLLKDRSTYEIMDPEAMGISRSMIILGRHSGRHAIKHRLSEYGIAVADNELNDVYDKFKQ 361 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEE--VKA 420 +AD+K V D +L +A + +P+ ++L V +GS A+V + GE+ ++ Sbjct: 362 VADEKKIVTDDELIRIAGEATET-QPDPYKLMDLQVLAGSQKSRIASVTIRDGEDGGERS 420 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 + G GP++AV I + + L + G+DA G+ + G RF G + Sbjct: 421 YSGMGEGPLEAVIHCIQQAIPVAAQFEDLELHSLSTGEDAHGEAVVSIVIEGERFRGTSI 480 Query: 481 ATDIV 485 DI+ Sbjct: 481 HKDII 485 >UniRef50_A6VFV4 Isopropylmalate/citramalate/homocitrate synthase n=7 Tax=Methanococcales RepID=A6VFV4_METM7 Length = 492 Score = 491 bits (1264), Expect = e-137, Method: Composition-based stats. Identities = 174/503 (34%), Positives = 272/503 (54%), Gaps = 19/503 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V IFDTTLRDGEQ SLS EKL+IA+ L+ +GV+++E G ++S G+ E+++ +A Q Sbjct: 2 VNIFDTTLRDGEQTPGVSLSPSEKLEIAIKLDELGVNIIEAGSAITSKGEREAIKLVAEQ 61 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 N+ + + R + DID A +H + TS +H+ KLR T +E ++ A++ Sbjct: 62 KLNAEISSFVRALPVDIDAAL----SCNVDSVHLVVPTSDLHMEYKLRKTREENLKDAMH 117 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 V A+ + VE S EDA R+ + L + + A I + DTVG P + +I Sbjct: 118 AVDYAKEHGLIVELSAEDATRSDVEFLKELFKKGEELKADRICLCDTVGILTPVKSMELI 177 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + V IS+H H+D G+A N+L+A+ AGA Q +NGIGERAGN SLEEV Sbjct: 178 KTMKAAVT----IPISIHCHNDFGMATANTLSAISAGADQCHVTINGIGERAGNASLEEV 233 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 +M++K D+ T I +++++ S++VS+ + +PANKA+VG AFAH +GIH DG+ Sbjct: 234 VMSLKSLYDM---ETNIQTEKLYKISRIVSKYMKLSVPANKALVGDNAFAHEAGIHVDGL 290 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 +K+ E YE + PE +G N+ ++ L SG+AA+K++++ M S + +Y Sbjct: 291 MKSTETYEPIGPEVVG-NRRKIILGKHSGKAALKYKLELMNIGLSHEQFEEVYSKIKAFG 349 Query: 365 DKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAV--KLACGEEVKA-- 420 D + D DL+ + + E LD +V SG+ A++ K A +K Sbjct: 350 DLGKYISDVDLKTVISQVQGVELERKVILDEITVMSGNKVSPLASINLKFANDCNIKDNI 409 Query: 421 -EAANGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHG 477 EAA G GPVDA A+ + ++EL YS+ A G DAL +V + Sbjct: 410 REAAYGLGPVDAAINAVKKALTGVADIELEDYSVRAMTGGTDALIEVVVHLRKGNEVVEV 469 Query: 478 VGLATDIVESSAKAMVHVLNNIW 500 D+V +S +AM+ +N + Sbjct: 470 RKAHGDVVMASVEAMMDGINLLI 492 >UniRef50_A8TGZ1 Isopropylmalate/citramalate/homocitrate synthase n=1 Tax=Methanococcus voltae A3 RepID=A8TGZ1_METVO Length = 574 Score = 487 bits (1253), Expect = e-136, Method: Composition-based stats. Identities = 178/527 (33%), Positives = 273/527 (51%), Gaps = 32/527 (6%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 IFDTTLRDGEQ + S +K KL+IA L+ +GV+ +E GFP++S G+FE+V+ I + Sbjct: 53 IFDTTLRDGEQTPEVSFPIKAKLEIASKLDELGVNTIEAGFPITSNGEFEAVKKIKQLDL 112 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 N+ +C L+RC KDID + + RIH FIATSP+H KL+ + ++++ + + Sbjct: 113 NATICGLSRCSNKDIDAVID----CDLDRIHLFIATSPLHREYKLKKSKEQILNKISESI 168 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 A+ + VEFS EDA RT + L RV + AI + I+IPDTVG P + +I Sbjct: 169 IYAKEHGLSVEFSAEDATRTELDYLIRVYKEAITSKVDYIDIPDTVGILTPKKMENLIKD 228 Query: 187 LYERV-------------------PNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEG 227 L + N+ ++SVH H+D GLAV NSL+A G Q+ Sbjct: 229 LKSGLETNKAINNSSTLTNQINIKSNMQMPVLSVHCHNDFGLAVANSLSAFEQGVSQIHC 288 Query: 228 AMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAI 287 +NGIGERAGN L E + ++K I I + + S+LV+ N+PI NK + Sbjct: 289 TVNGIGERAGNTDLAEFVSSLKFLCGIEPETLTIKTELLSDISKLVAHYTNIPIAPNKPL 348 Query: 288 VGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGY- 346 VG AFAH SGIH GV+ N YE ++P +G N+ +L L +G ++K ++ EMG Sbjct: 349 VGRNAFAHESGIHTHGVIANALTYEPISPFDVG-NKRRLVLGKHAGAHSIKLKLQEMGLN 407 Query: 347 ---KESEYNLDNLYDAFLKLADKKGQVFDYDLEALA--FIGKQQEEPEHFRLDYFSVQSG 401 S + + D L DK V D DL A+ K + L+ +V +G Sbjct: 408 VGKNLSTEQFEEIVDKIKALGDKGKLVLDADLRAIIKDVTSKVIKSKRVVNLEQLAVITG 467 Query: 402 SNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKD 459 N I TA+V + + + G GPVDA +A+ + +L++Y++ A G D Sbjct: 468 INVIPTASVAVNIAGKRYKASEMGVGPVDASLKALESVVGETVKAKLIEYTINAATGGSD 527 Query: 460 ALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVE 506 A+ V + N + + D+V +S +A++ +N + + + Sbjct: 528 AIADVVVKLENNKKIVTAKSTSEDVVHASVEAVIEGINRLLDESTIN 574 >UniRef50_A8V4T9 2-isopropylmalate synthase (Fragment) n=2 Tax=cellular organisms RepID=A8V4T9_9AQUI Length = 432 Score = 485 bits (1249), Expect = e-135, Method: Composition-based stats. Identities = 229/422 (54%), Positives = 296/422 (70%), Gaps = 3/422 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++IIFDTTLRDGEQA S++V+EK+++A LE++GVDV+E GF +S GDFE+V +A Sbjct: 12 RKLIIFDTTLRDGEQAPGFSMTVEEKVRMAKQLEKLGVDVIEAGFAAASKGDFEAVNEVA 71 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 ++VKNS VC+LAR + DI+ A E+L AE RIHTFIATSP+H+ KLR T ++V+ERA Sbjct: 72 KEVKNSTVCSLARALHSDIERAGEALAPAERKRIHTFIATSPIHMEYKLRMTPEQVLERA 131 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + V+ ARN+TDDVEFS EDA R+ L R+ EA I AGA TIN+PDTVGY +P EF Sbjct: 132 VDAVQFARNFTDDVEFSAEDAVRSEREFLYRIFEAVIAAGAKTINVPDTVGYAVPEEFGQ 191 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 +IS + VPNIDKA+ISVH H+DLGLAV NSL AV GA QV +NGIGERAGN +LE Sbjct: 192 LISDILNNVPNIDKAVISVHCHNDLGLAVANSLTAVKNGAGQVHSTINGIGERAGNAALE 251 Query: 243 EVIMAIKVRKDIL-NVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EV+MAIKVRKD +V+T IN +EI+RTS+L+ ++ + NKAIVG AFAH +GIHQ Sbjct: 252 EVVMAIKVRKDYFKDVYTDINTKEIYRTSRLLCRLTGSFVQPNKAIVGDNAFAHEAGIHQ 311 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK-ESEYNLDNLYDAF 360 G+L RE YEIM E +G+ ++ L SGR A K R++E+GYK SE +D L+ F Sbjct: 312 HGLLAKRETYEIMKAEDVGVPSSKIVLGKHSGRHAFKTRLEELGYKNLSEEEIDKLFAKF 371 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 +LADKK +VFD D+EAL F + E +L F + SG+ I TA VKL E Sbjct: 372 KELADKKKEVFDEDIEALLFDELFKSY-EEVKLLQFQIVSGNKAIPTATVKLKIDGEEIV 430 Query: 421 EA 422 Sbjct: 431 ST 432 >UniRef50_C5SF21 Pyruvate carboxyltransferase n=1 Tax=Asticcacaulis excentricus CB 48 RepID=C5SF21_9CAUL Length = 527 Score = 473 bits (1218), Expect = e-132, Method: Composition-based stats. Identities = 205/496 (41%), Positives = 286/496 (57%), Gaps = 6/496 (1%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 +VI+FDTTLRDGEQA SL VK+KL +A L+ +GVDV+E GF SSPGD E+++TI Sbjct: 9 PNRVIVFDTTLRDGEQAPGFSLGVKDKLMLAHTLKDLGVDVIEAGFAASSPGDEEAIRTI 68 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 AR+V C+L+R +E DID AA +L A+ R H F+ATSP+H A KL+ T ++V+E Sbjct: 69 AREVVGPTFCSLSRALESDIDAAARALLPAKRKRCHIFLATSPIHRAAKLKKTREQVVEI 128 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 A V A D+VEFS EDA RT L V AA AGA T+NIPDTVGYT P E Sbjct: 129 AHKAVSYASTIFDEVEFSPEDAIRTEQDFLHEVCIAAAEAGARTLNIPDTVGYTTPKEIY 188 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 I S L + + + I+S H HDDLGL V N+LAA+ AGARQ+E +NGIGERAGN +L Sbjct: 189 QIFSDLKAALKDHPQVILSAHNHDDLGLGVANTLAALEAGARQIEVTINGIGERAGNAAL 248 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EEV+MA++ R ++ +HT IN + + S L+S+ + NKA+VG AFAH SGIHQ Sbjct: 249 EEVVMALRTRPELFKLHTGINTPLLSKASHLLSRATGTIVMRNKAVVGRNAFAHESGIHQ 308 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 G+L + YEIM PE +G + L L SGR A+ + +G+ E +L +L+ AF Sbjct: 309 HGMLTDARTYEIMRPEDVGAEKSNLVLGKHSGRHAIAKQAAALGFDLDELSLGDLFAAFK 368 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSG-SNDIATAAVKL-ACGEEVK 419 + AD+ G++ +++L +L + + + + RL F V S + D T + L E Sbjct: 369 RRADEIGEIDEFELMSL--LTRDNADKDDARL--FKVSSEVTKDFVTITLDLFRDNGEPL 424 Query: 420 AEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVG 479 A G +A ++A+ + + + G D +I G + G G Sbjct: 425 KVTATGLNAFEAGFRALVDAYQIEARVNDCEIIQSGFTFDGGAFAEISLQIKGEAYRGRG 484 Query: 480 LATDIVESSAKAMVHV 495 D V + +AM Sbjct: 485 RGPDPVWAGLRAMCDA 500 >UniRef50_Q0AT07 2-isopropylmalate synthase n=3 Tax=Alphaproteobacteria RepID=Q0AT07_MARMM Length = 529 Score = 472 bits (1215), Expect = e-131, Method: Composition-based stats. Identities = 203/517 (39%), Positives = 299/517 (57%), Gaps = 7/517 (1%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 ++ IFDTTLRDGEQA S++ EKL+IA LE M VD +E GF +SPGD E+++ I Sbjct: 14 PDRLRIFDTTLRDGEQAPGFSMNPAEKLEIARLLEAMRVDTIEAGFAAASPGDSEAIRLI 73 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 A +++NS +C+LAR E DID AA++L+ A R+H F+ATSP+H KLR + EV++ Sbjct: 74 ASEIRNSTLCSLARATEGDIDAAAKALEPAHRKRLHIFLATSPIHREAKLRMSRREVLQT 133 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 +K A D++EFS EDA RT L + A GA +N+PDTVGY+ P E Sbjct: 134 IERCLKHAAGTFDEIEFSAEDALRTEPDFLVEAMSCAAVNGADVLNVPDTVGYSEPDEIR 193 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 + L V D I S H H+DLGLAV NSLAAV GARQVE A+NGIGERAGNCSL Sbjct: 194 AVFERLAAHVERPDHVIFSAHCHNDLGLAVSNSLAAVKGGARQVECAINGIGERAGNCSL 253 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EE++MA++VR DI + ++ +IW SQ ++++ + NKAIVG AFAH +GIHQ Sbjct: 254 EEIVMALQVRADIFPAISHVDATKIWSASQRLARVTGSAVAPNKAIVGKNAFAHEAGIHQ 313 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 G++ +R YEIMTPES+G L L SG+ A+ R+ ++GY+ L+ ++ F Sbjct: 314 HGMISDRRTYEIMTPESVGAPGSALVLGKHSGKHALVQRLAKLGYQPDPDKLNQVFKDFK 373 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA- 420 LAD+ G+V D DL A+ +G A V+L + + Sbjct: 374 HLADELGEVNDADLVAMMEGFSASGSRWTVLRTELRTTAGRQPKQFARVELEHPDRGRVS 433 Query: 421 EAANGNGPVDAVYQAINRITEYNVEL--VKYSLTAKGHGKDALGQVDIVANYNGRRFHGV 478 + A+G+GP+ A + A+ RIT + + ++ + + G++ + DI + +G F G Sbjct: 434 DIASGDGPIAAAFAAVQRITGTDATVTALETRMRSTATGREFVA--DISIDIDGTIFSGR 491 Query: 479 GLATDIVESSAKAMVHVLNN--IWRAAEVEKELQRKA 513 DIV ++ +++ L+ + A++ ++ A Sbjct: 492 ARGPDIVTAAIDSLLFTLDRGEAYGRADLTQQQPAAA 528 >UniRef50_D2RVT7 Pyruvate carboxyltransferase n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT7_9EURY Length = 508 Score = 452 bits (1164), Expect = e-125, Method: Composition-based stats. Identities = 168/504 (33%), Positives = 261/504 (51%), Gaps = 18/504 (3%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + V + DTTLRDGEQA SL+ EK+ IA +LE+ GV V+E G + G+ +++ + Sbjct: 13 RTVRLLDTTLRDGEQAPGVSLTPDEKVDIARSLEQAGVSVIEAGSACTGAGERQAISRVT 72 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 ++RV + R +E DID+A + + +H + S HI K+ ++ ++ +E+ Sbjct: 73 DLELDARVTSFCRGMESDIDLALD----CDVDGVHIVVPASDRHIEDKVGTSHEDNLEKT 128 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 +V A+++ VE ED R + L ++ A++AGA I DTVG+T P A Sbjct: 129 AELVAYAKDHDLWVEVIGEDGSRADLDYLEELMATAVDAGADRICFADTVGHTGPERTAE 188 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + L + P +S HTHDDLGL V N+LAAV AGA V +NG+GERAGN +LE Sbjct: 189 AVGRLADVGP------VSAHTHDDLGLGVANALAAVSAGADLVHCTVNGLGERAGNVALE 242 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV +A+ D+ + E++ +Q VS+ + +P NKA++G AF H SGIH D Sbjct: 243 EVAIALSHVYDVET----LELTELYDLAQTVSRATGIQLPPNKAVIGENAFTHESGIHTD 298 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G LK+ + YE PE++G + +L L +GRA V ++E G + + + + Sbjct: 299 GTLKDDKMYEPYAPETVGRER-RLALGKHTGRAGVTATLEEHGVEADSDEVAEIATRVTE 357 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEA 422 L D+ +V D DL A+A + L + SG + TA+V+L E + + Sbjct: 358 LGDRGRRVTDADLLAIAEDVTGDDRERVVELLDLNATSG-GAVPTASVRLEVDGEERVAS 416 Query: 423 ANGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 G+GPVDA A+ + EL Y + A G DA+ V++ N R Sbjct: 417 GTGSGPVDAAVSAVREALGSMADAELDSYHVDAVTGGTDAVVTVEVTMMRNDRSVTVARS 476 Query: 481 ATDIVESSAKAMVHVLNNIWRAAE 504 DI +S +AMV L+ + A + Sbjct: 477 EADITRASVEAMVDALDRLLAADQ 500 >UniRef50_Q18KM5 2-isopropylmalate synthase n=9 Tax=Euryarchaeota RepID=Q18KM5_HALWD Length = 531 Score = 447 bits (1150), Expect = e-124, Method: Composition-based stats. Identities = 172/498 (34%), Positives = 260/498 (52%), Gaps = 18/498 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V + DTTLRDGEQA SL EK +IA L+R G++ +E G + G+ E+++ + Sbjct: 23 VQLLDTTLRDGEQAPGISLDPDEKAEIARELDRSGIEFIEAGSACTGEGERETIRQVTGL 82 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 ++ V + AR V+ DI++A + + + S HI TK+ ST EV+ Sbjct: 83 DLDATVTSFARGVKSDIELAVD----CGVDGVTIVVPASDQHIETKVGSTRSEVVTTTAE 138 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 +V+ A+++ VE ED R I L R++ A++AGA DTVG+ P + Sbjct: 139 LVEYAKDHDLWVEVIGEDGSRADIEFLERLMREALDAGADRSCYADTVGHANPETTYEYV 198 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 S L P +S HTHDDLGLA+ N ++ AGA V G +NGIGERAGN +LEEV Sbjct: 199 SRLAALGP------VSTHTHDDLGLAMTNVWVSLAAGADLVHGTVNGIGERAGNVALEEV 252 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 +A+ DI +++ +Q VSQ N+P+P NKA++G AF H SGIH DG Sbjct: 253 AIALAHGYDIETAT----LDQLYSLAQTVSQATNIPLPPNKAVIGENAFTHESGIHTDGT 308 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 LK++ YE +P S+G + +L L +GRA V+ +DE SE + + D +L Sbjct: 309 LKDKTMYEPYSPSSVGRER-RLVLGKHAGRAGVQAALDEHRIDVSEDEVTAIVDRVKELG 367 Query: 365 DKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAAN 424 D+ +V D DL +A + +E H L + SG TA+++L GE + + Sbjct: 368 DRDKRVTDADLLTIAEEVQGRERDRHVELLDLTAASG-GGTPTASIRLRVGENERVASGT 426 Query: 425 GNGPVDAVYQAINRI--TEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLAT 482 G+GPVDA +A+ T+ + +L Y + A G DA+ V++ + R + Sbjct: 427 GSGPVDAAVEAVRAALGTDADAQLDSYHVDAITGGTDAVVTVEVEMSRGDRTVSVATSDS 486 Query: 483 DIVESSAKAMVHVLNNIW 500 DI S +AMV L+ + Sbjct: 487 DITRCSVEAMVEALDRLL 504 >UniRef50_O66682 Uncharacterized AIPM/Hcit synthase family transferase aq_356 n=44 Tax=Bacteria RepID=LY41_AQUAE Length = 528 Score = 444 bits (1143), Expect = e-123, Method: Composition-based stats. Identities = 159/533 (29%), Positives = 275/533 (51%), Gaps = 33/533 (6%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+++V I+DTTLRDG Q S S+++K++IA L+ G+ +E G+P ++P D Q Sbjct: 1 MAEKVYIYDTTLRDGSQMEGVSFSLEDKIRIAEKLDDFGIHYIEGGWPYANPKDNLFFQK 60 Query: 61 IARQ-VKNSRVCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + KN+++ A + D ESL AE + F + +H+ L++TL Sbjct: 61 AKKMNFKNAKLTAFGSTRRPNKKVSEDPQVESLIKAETPVVTIFGKSWDLHVTDALKTTL 120 Query: 116 DEVIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTV 172 +E + V+ + Y D+V F E D ++ +V+EAA+ GA + + DT Sbjct: 121 EENLNMIYETVEYLKRYVDEVIFDAEHFFDGYKSNPEYALQVLEAALKGGADWVVLCDTN 180 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G T+P E I + ER + A + +H H+D AV NSL AV AGARQV G +NGI Sbjct: 181 GGTLPHEIYEITKKVKERFKD---ANVGIHAHNDSETAVANSLMAVLAGARQVHGTINGI 237 Query: 233 GERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 GER GN +L +I ++++ +V N +++ + V++I NMP+P N VG A Sbjct: 238 GERTGNANLCSIIPNLQLKLGF-DVIPQENLKKLTELANFVAEIINMPLPRNMPYVGESA 296 Query: 293 FAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEY- 351 FAH G+H VLKN + YE + PE +G N+ ++ ++ +GR+ + H++ E G + Sbjct: 297 FAHKGGVHASAVLKNAKTYEHINPELVG-NKRKITVSDLAGRSNLVHKLKEFGIEIDPKS 355 Query: 352 -NLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQE--EPEHFRLDYFSV-----QSGSN 403 L L D +L +K+G F+ +L + K+ ++F D + V + S Sbjct: 356 PELKKLIDKIKEL-EKEGYHFEAAEASLELLIKRHFGLVKDYFDFDAYRVLIAKRRDDSL 414 Query: 404 DIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEY------NVELVKYSLTAKGH- 456 + A V+L+ + A+ GNGP+ A+ +A+ + E ++L+ Y + Sbjct: 415 PTSEATVRLSVEGVEEHTASLGNGPISALDRALRKALEEFYPNLKELQLIDYKVRIINES 474 Query: 457 -GKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKE 508 G A +V I + R++ VG++ +++E+S A+ + +++ + E+E Sbjct: 475 AGTSAKVRVLIESTDGKRKWGTVGVSENVIEASWIALRDSI--VYKLMKDEEE 525 >UniRef50_D2RHQ3 Isopropylmalate/citramalate/homocitratesynthase n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RHQ3_ARCPR Length = 529 Score = 444 bits (1142), Expect = e-123, Method: Composition-based stats. Identities = 166/540 (30%), Positives = 259/540 (47%), Gaps = 56/540 (10%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + I DTTLRDGEQ SL+V++KL IA AL+ +GVDV+E G ++ +F +V+ IA Sbjct: 2 LRILDTTLRDGEQTPGVSLTVEQKLIIAQALDDLGVDVIEAGTAIAGEEEFRAVKEIANA 61 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKL-RSTLDEVIERAI 123 + +C+ AR E DID A A+A + +S +HI TK + D++IE ++ Sbjct: 62 GLKAEICSFARIKEIDIDAVAN----ADADSVFMVAPSSDIHIKTKFPNKSGDDIIEMSV 117 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 V+ A+ VEF ED+ R + + + A ++AGA + DTVG P + I Sbjct: 118 KAVEYAKERGLIVEFGAEDSSRANLNFVKALFRAVLDAGADRLTFTDTVGVLTPEKAECI 177 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 + L I+ H H+D GLA N++ AV GAR++ +NG+GERAGN LEE Sbjct: 178 MRELTSEF----NVPIAFHGHNDFGLATANTIFAVKGGAREIHVTINGLGERAGNAPLEE 233 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 V++A++ I T I ++I+ TS+LV + PI NK IVG AF H SGIH Sbjct: 234 VVLALETFYGI---KTKIRKEKIYDTSKLVEALTRFPIALNKPIVGYNAFMHESGIHTSA 290 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 +L+N + YE ++PE IG + + SG+A++ ++E+GY+ S + + ++ Sbjct: 291 LLRNAKAYEPISPEMIGRKRA-IVHGKHSGKASIMRLIEELGYEASGEQVKEIMKRIKEM 349 Query: 364 ADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSG-SNDIATAAVKLACGEEVKAEA 422 + +V DL + + ++ + L +V G S A++K+ E Sbjct: 350 EGRGQKVMGSDLIKIIEEVLKVKKGKKIVLKGLNVVCGKSGTSPHASIKICLNGEDIEAT 409 Query: 423 ANGNGPVDAVYQAINRITE--------------YNVELVKYSLTA--------------- 453 A G GP DA +A+ + NV+LV Y A Sbjct: 410 ALGKGPFDASIRALKNALKEYANKSGDKAVGELVNVKLVNYKANAIIDDKVIEYIEKLVE 469 Query: 454 -------------KGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIW 500 G DA V I + R +G +TDI+ +S +A + LN + Sbjct: 470 KNPKLSGLVEKIRIMTGTDAPVDVIIQLEKDDRVVTAIGRSTDIIHASVEAYIECLNKLI 529 >UniRef50_C6PDK4 Pyruvate carboxyltransferase n=1 Tax=Thermoanaerobacterium thermosaccharolyticum DSM 571 RepID=C6PDK4_CLOTS Length = 397 Score = 436 bits (1121), Expect = e-120, Method: Composition-based stats. Identities = 173/380 (45%), Positives = 245/380 (64%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 ++VI+FDTTLRDGEQ + K +IA L +GVDV+E GFP +S G+FE+V+ IA Sbjct: 4 RKVIVFDTTLRDGEQTPGVNFDKDSKYRIAKQLVSLGVDVIEAGFPAASNGNFEAVKHIA 63 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 + + V L+RCV+ DID E+LK A+ RIH FIATS +H+ KL+ + DE ++ A Sbjct: 64 ENIDDVVVAGLSRCVKSDIDKTYEALKNAKKSRIHLFIATSDIHLKYKLKISRDEALKMA 123 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + VK A D+++FS EDA RT L ++ ++AGA INIPDTVGY +P EF Sbjct: 124 VDSVKYASGKFDEIQFSAEDASRTDWDFLVKIFNEVVDAGAKIINIPDTVGYAVPKEFEK 183 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 ++ + + + + D ISVH H+DLG+AV NSL+A+ GA QVE + GIGERAGN SLE Sbjct: 184 LVEYVKKHIHDKDNVTISVHCHNDLGMAVVNSLSALENGADQVEVTVCGIGERAGNASLE 243 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EVIMAI RKD N+ +IN +EI+ T +LVS++ + + NKAIVGS AF H++GIHQ Sbjct: 244 EVIMAINTRKDYFNLLHSINTREIFSTCKLVSELSGIDLQPNKAIVGSNAFRHTAGIHQH 303 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 GV+ N+ YEIM PE IG+ +++ SGR A + ++ MGY+ S ++ + F Sbjct: 304 GVINNKATYEIMRPEDIGITTDHISMGKLSGRNAFELKLKNMGYELSRDEMNLAFKKFKD 363 Query: 363 LADKKGQVFDYDLEALAFIG 382 +AD K V D +++A+ Sbjct: 364 VADNKKIVNDNEIKAIVDDV 383 >UniRef50_Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic n=19 Tax=Brassicaceae RepID=MAM3_ARATH Length = 503 Score = 436 bits (1121), Expect = e-120, Method: Composition-based stats. Identities = 167/406 (41%), Positives = 258/406 (63%), Gaps = 17/406 (4%) Query: 1 MSQQ--VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESV 58 + + V + DTTLRDGEQ+ A+L+ +KL+IA L ++ VD+MEVGFPVSS +FE++ Sbjct: 79 LPHKNYVRVLDTTLRDGEQSPGAALTPPQKLEIARQLAKLRVDIMEVGFPVSSEEEFEAI 138 Query: 59 QTIARQVKN---------SRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIAT 109 +TIA+ V N +C +ARC ++DI+ E+LK A+ R+ F +TS +H+ Sbjct: 139 KTIAKTVGNEVDEETGYVPVICGIARCKKRDIEATWEALKYAKRPRVMLFTSTSEIHMKY 198 Query: 110 KLRSTLDEVIERAIYMVKRARNYTD-DVEFSCEDAGRTPIADLARVVEAAINAGATTINI 168 KL+ T +EVIE A+ VK A++ D++F CED GRT + +++ +I AGATT+ Sbjct: 199 KLKKTKEEVIEMAVNSVKYAKSLGFKDIQFGCEDGGRTEKDFICKILGESIKAGATTVGF 258 Query: 169 PDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGA 228 DTVG MP EF +++ + E P D + ++H H+DLG+A N+++ + AGARQVE Sbjct: 259 ADTVGINMPQEFGELVAYVIENTPGADDIVFAIHCHNDLGVATANTISGICAGARQVEVT 318 Query: 229 MNGIGERAGNCSLEEVIMAIKVRKD--ILNVHTAINHQEIWRTSQLVSQICNMPIPANKA 286 +NGIGER+GN LEEV+MA+K R + + V+T I+ ++I TS++V + M + +K Sbjct: 319 INGIGERSGNAPLEEVVMALKCRGESLMDGVYTKIDSRQIMATSKMVQEHTGMYVQPHKP 378 Query: 287 IVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQ---LNLTSRSGRAAVKHRMDE 343 IVG F H SGIHQDG+LKNR YEI++PE +G+ + + + L SGR AVK R+ E Sbjct: 379 IVGDNCFVHESGIHQDGILKNRSTYEILSPEDVGIVKSENSGIVLGKLSGRHAVKDRLKE 438 Query: 344 MGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPE 389 +GY+ S+ ++++ + +L K ++ D DL+AL G + + Sbjct: 439 LGYEISDEKFNDIFSRYRELTKDKKRITDADLKALVVNGAEISSEK 484 >UniRef50_Q2RGA1 2-isopropylmalate synthase n=5 Tax=Clostridia RepID=Q2RGA1_MOOTA Length = 533 Score = 432 bits (1111), Expect = e-119, Method: Composition-based stats. Identities = 148/537 (27%), Positives = 267/537 (49%), Gaps = 29/537 (5%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+++++I+DTTLRDG Q SLSV++KL+IA L+R+GVD +E G+P ++P D E Sbjct: 1 MAEKILIYDTTLRDGSQGEGISLSVEDKLKIASRLDRLGVDYIEGGWPWANPKDMEFFLR 60 Query: 61 IARQV-KNSRVCALARCVEKDIDVAAE----SLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + + +R+ A R + A + ++K A F + +H+ L +TL Sbjct: 61 AREVIWRQARLVAFGRTRKPGQAAAEDANLLAIKRAGVKVATIFGKSWDLHVTAALGTTL 120 Query: 116 DEVIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTV 172 E + V + +V + E D + ++AA AGA+ I + DT Sbjct: 121 AENLAMIGDSVAFLVDQGLEVIYDAEHFFDGFKANPDYALETLKAAAKAGASWIVLCDTN 180 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G +P+E ++ + + + + + +H H+D LAV N+LAAV AG RQV+G +NG Sbjct: 181 GGCLPWEIEEAVARVRQEI----QVPVGIHAHNDGDLAVANTLAAVTAGCRQVQGTINGF 236 Query: 233 GERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 GER GN L V+ ++++ + + S+ VS+I N+ N+ VG A Sbjct: 237 GERCGNADLCSVMPNLELKMGYQCLPPG-QLAFLTEVSRYVSEIANVVPAGNQPFVGYSA 295 Query: 293 FAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYN 352 FAH GIH VLK + YE + P+ +G N+ ++ ++ ++G + ++ + +EMG + + Sbjct: 296 FAHKGGIHVSAVLKAPDTYEHIRPQQVG-NERRVLMSDQAGASNLRCKAEEMGLELNPER 354 Query: 353 LDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQ--EEPEHFRLDYFSV----QSGSNDIA 406 + + +L +++G F+ +L ++ E + F ++Y ++G I+ Sbjct: 355 ERGIIEGIKEL-ERQGYQFEGADASLELFLRKTTGEYRQQFEVEYVKALVEKRAGQEAIS 413 Query: 407 TAAVKLACGEEVKAEAANGNGPVDAVYQAINRITE------YNVELVKYSLTAKGH--GK 458 A VKL G++V AA GNGPV+A+ A+ + E ++ L Y + Sbjct: 414 EAIVKLRVGDQVVHTAAEGNGPVNAMDNALRKALEEVFPAIRHMRLTDYKVRVLDEKDAT 473 Query: 459 DALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQH 515 A +V I + ++ VG++T+I+E+S +A++ + + E + A Sbjct: 474 SARVRVLIESRDGSNSWNTVGVSTNIIEASWEALLDSMEYALLKQQQELNKRAAAPC 530 >UniRef50_A8AB61 2-isopropylmalate synthase n=25 Tax=Archaea RepID=LEU1_IGNH4 Length = 399 Score = 425 bits (1093), Expect = e-117, Method: Composition-based stats. Identities = 158/387 (40%), Positives = 229/387 (59%), Gaps = 11/387 (2%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + ++V IFDTTLRDGEQ S + ++KL IA L ++GV +E GFP S G+FE+V+ Sbjct: 16 LPKEVRIFDTTLRDGEQTPGISFTKEQKLMIARQLAKLGVASIEAGFPAVSQGEFEAVKA 75 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 IAR+ + ALAR ++DID A + A+ IH FIA S +H+ KLR T +E + Sbjct: 76 IAREGLGPEIVALARANKRDIDKALD----ADVDAIHVFIAASDIHLKYKLRMTREEALR 131 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 RA+ V+ A+++ VEFS ED R + L +VEA ++AGA ++IPDTVG P Sbjct: 132 RAVEAVEYAKSHGVTVEFSPEDGTRADLNYLYTMVEAVVDAGADRVDIPDTVGVMTPTRM 191 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 +I + +P I+SVH H+D GLAV NS+A + AGARQ +NGIGERAGN + Sbjct: 192 KYLIKFI---LPAAKGRIVSVHCHNDFGLAVANSIAGIEAGARQAHVTVNGIGERAGNAA 248 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV+ A++ +LNV T +N + ++ TS LVS+I +PIP NK IVG F+H SGIH Sbjct: 249 LEEVVAALEF---LLNVRTGVNTKLLYETSLLVSKITGIPIPPNKPIVGENVFSHESGIH 305 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 GV+ N YE + PE +G + ++ L SGR V++ + +GY + + D Sbjct: 306 VHGVINNPFTYEPIQPEMVG-QRRRIVLGKHSGRHGVEYALKTLGYPTDPDVVLRVLDEV 364 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEE 387 +L D +V + L + ++ E Sbjct: 365 KRLGDMGIRVTEDKLREIVEKVLEERE 391 >UniRef50_D2MJY3 2-isopropylmalate synthase n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MJY3_9BACT Length = 405 Score = 423 bits (1087), Expect = e-116, Method: Composition-based stats. Identities = 186/401 (46%), Positives = 261/401 (65%), Gaps = 7/401 (1%) Query: 112 RSTLDEVIERAIYMVKRARNYTDD-----VEFSCEDAGRTPIADLARVVEAAINAGATTI 166 R+T ++ + A V A++ +D VEFS DAGRT +A L VVEA I AGAT + Sbjct: 6 RTTPEDTLRMATAAVAYAKSLCEDHPDANVEFSPMDAGRTELAFLYEVVEATIAAGATVV 65 Query: 167 NIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVE 226 NIP+TVG+T+P EF +I + E VPN+D AIISVH H+DLGLAV NSL A+ GARQVE Sbjct: 66 NIPETVGWTVPTEFGNLIKSIMENVPNVDDAIISVHCHNDLGLAVANSLIAIEQGARQVE 125 Query: 227 GAMNGIGERAGNCSLEEVIMAIKVRKDIL-NVHTAINHQEIWRTSQLVSQICNMPIPANK 285 +NG+GERAGN SLEEV+MAI+ R+D N +T IN +EI S+ VS+ + + NK Sbjct: 126 CTINGLGERAGNTSLEEVVMAIRTRRDYFKNYYTEINAKEIVPISRRVSRTMGIAVQPNK 185 Query: 286 AIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMG 345 AIVG+ AFAHSSGIHQDG++K+R +EI+ P+ IG + QL L+ RSGR A++HR+ E+G Sbjct: 186 AIVGANAFAHSSGIHQDGIIKSRVTFEIIDPQEIGWKESQLILSPRSGRNALRHRLSELG 245 Query: 346 YKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDI 405 Y+ LD +Y+ FLK+ADKK + D DLEA+ + + P F LDY V SG+ Sbjct: 246 YEVEGAQLDKVYERFLKVADKKKSIQDADLEAIMS-DEIRAIPAIFELDYIQVVSGTKIS 304 Query: 406 ATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVD 465 T V + + V +A+ G+GPVDA ++AI ++ + + LV Y + + G+DA+G+V Sbjct: 305 PTTTVGIRTEDGVVEKASTGDGPVDAAFKAIAQVVDIQLNLVDYQIRSVTEGEDAIGEVS 364 Query: 466 IVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVE 506 + NG G G +TDI+E+SA+A +H +N + + Sbjct: 365 LKVQDNGHIITGHGASTDIIEASARAYIHAVNKLIQIRSEG 405 >UniRef50_C3NF24 2-isopropylmalate synthase/homocitrate synthase family protein n=19 Tax=Thermoprotei RepID=C3NF24_SULIN Length = 553 Score = 413 bits (1062), Expect = e-114, Method: Composition-based stats. Identities = 139/523 (26%), Positives = 250/523 (47%), Gaps = 30/523 (5%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + V + DTTLRDG Q S ++ +K++IAL L+ +GV+ +E G+P S+P D E + I Sbjct: 31 KSVEVLDTTLRDGSQGANISFTLNDKIKIALLLDELGVEYIEGGWPGSNPKDEEFFKEIK 90 Query: 63 R-QVKNSRVCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + ++ +R+ A KD+ D++ S+ A+ F + +H L+ T + Sbjct: 91 KYKLSKARIAAFGSTKRKDVSVKEDISLNSIIKADVDFAVIFGKSWSLHATEVLKVTKQD 150 Query: 118 VIERAIYMVKRARNYTDDVEFSCEDA---GRTPIADLARVVEAAINAGATTINIPDTVGY 174 ++ + R++ V F E + VV+ A +AGA I + DT G Sbjct: 151 NLDIIYDSINYLRSHGLKVIFDAEHFYQGFKEDPKYALEVVKTAESAGADVIALADTNGG 210 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 T PFE I + E + + +H H+D+G AV NSL A+ AGAR V+G +NGIGE Sbjct: 211 TPPFEVYEITKKVREVLH----VKLGIHAHNDIGCAVANSLMAIKAGARHVQGTINGIGE 266 Query: 235 RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFA 294 R GN L ++I + ++ + + +++ S++V +I +P + VG AFA Sbjct: 267 RTGNADLIQIIPTLVLKMGFNVLKGRDSLRKLREVSRIVYEILGLPPNPYQPYVGDNAFA 326 Query: 295 HSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGY--KESEYN 352 H +G+H D V+K YE + P +G ++ + ++ SG A + + +G + + Sbjct: 327 HKAGVHVDAVMKVPRAYEHVDPLLVGNDR-KFVISELSGTANLVSYLQGIGIVVDKKDER 385 Query: 353 LDNLYDAFLKLADKKGQVFDY--DLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAV 410 L + +L + KG FD L + + + L+Y+ V + +N ++ V Sbjct: 386 LKKALNKIKEL-ETKGYSFDVGPASAILITLKELNMYTNYINLEYWKVINENNGLSIGIV 444 Query: 411 KLACGEEVKAEAANGNGPVDAVYQAINRITEY------NVELVKYSLTAKGH--GKDALG 462 K+ + E A G GPV+A+ +A+ + V+L+ Y + +++ Sbjct: 445 KV----NSQLEVAEGVGPVNAIDRALRMALQRVYPEISEVKLIDYRVILPSEVKNTESVV 500 Query: 463 QVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 +V I N + G++ +VE+S A+V L+ + + Sbjct: 501 RVTIEFTDNKMNWRTEGVSKSVVEASVMALVDGLDYYLQLKKT 543 >UniRef50_A8HXS9 Isopropylmalate synthase (Fragment) n=1 Tax=Chlamydomonas reinhardtii RepID=A8HXS9_CHLRE Length = 444 Score = 407 bits (1047), Expect = e-112, Method: Composition-based stats. Identities = 174/459 (37%), Positives = 254/459 (55%), Gaps = 42/459 (9%) Query: 79 KDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTD-DVE 137 +D++ A ++++ A+ R+HTFIATS +H+ + + + A+ VK R+ D+E Sbjct: 1 QDLERAWDAVRHAKRPRVHTFIATSEIHMKVSQQGSATSGLHNAVAAVKHLRSLGCTDIE 60 Query: 138 FSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKA 197 FS EDAGR+ L R++ I AGATT+NIPDT G+ +P EF +I+ + + P D Sbjct: 61 FSSEDAGRSDPKFLYRILGEVIKAGATTLNIPDTTGWCLPHEFGELIAAIKKNTPGADNV 120 Query: 198 IISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNV 257 IIS H +DLGL+ NSLA AGARQ+E +NGIGERAGN SLEEV+MAIK+R Sbjct: 121 IISTHCQNDLGLSTANSLAGAQAGARQIECTINGIGERAGNASLEEVVMAIKLRG----- 175 Query: 258 HTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPE 317 ++VS M + A+KAIVG+ AFAH SGIHQDG+LKNRE YEIM+PE Sbjct: 176 -------------KMVSDYSGMVVQAHKAIVGANAFAHESGIHQDGMLKNRETYEIMSPE 222 Query: 318 SIGLNQ----IQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDY 373 SIGL + + L SGR A+ R+ +GY+ S+ LD+++ F LADKK + D Sbjct: 223 SIGLPRQEQDRGIVLGKHSGRNALNSRLRTLGYELSQSELDDVFKRFKALADKKKGITDE 282 Query: 374 DLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEV-KAEAANGNGPVDAV 432 D+ AL + + + L V G+ + TA V++ + + + G GPVDA Sbjct: 283 DILALMS-DELHQPKVIWELLDLQVVCGTMGMPTATVQMKGPDGIARIGVGVGTGPVDAA 341 Query: 433 YQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNG-----------------RRF 475 Y+A++ + EL YS+++ G +AL ++ +G R+F Sbjct: 342 YKAVDSLVRVEAELSDYSVSSVTQGIEALAHTRVMIRPSGKMSDAGYSEHAALGTVQRQF 401 Query: 476 HGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQ 514 G G DIV +SA+A V LN + V + + + Sbjct: 402 SGSGANEDIVVASARAYVSALNKMIGWRRVGRRREWASS 440 >UniRef50_B1MVR2 2-isopropylmalate synthase n=1 Tax=Leuconostoc citreum KM20 RepID=B1MVR2_LEUCK Length = 398 Score = 406 bits (1045), Expect = e-112, Method: Composition-based stats. Identities = 158/387 (40%), Positives = 235/387 (60%), Gaps = 1/387 (0%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+ Q+ +D T+RDGEQ + + ++ EK+++A ALE+ GV +E GFP +S DF++V Sbjct: 7 MTNQITFYDPTMRDGEQTIGVNFTIDEKIKLAQALEKYGVSAIEAGFPAASKKDFDAVVE 66 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I++ V ++V LAR V +DID + + A+ IH FIATSP+H KL + E+IE Sbjct: 67 ISKVVHTAKVVGLARLVRQDIDAVVAATQQAKHPMIHVFIATSPVHRTYKLHMSPSEIIE 126 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 + I ++ + ++ FS EDA RT LARV++AAI +GAT INIPDTVGY P+E+ Sbjct: 127 KVISDIRYTKTMMSEIIFSPEDATRTEPEFLARVIQAAIESGATMINIPDTVGYATPYEY 186 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 + L E V + D+ + HTH+DLG+A N+LA + GA +++G +NGIGERAGN Sbjct: 187 GELFEYLREHVRDFDQVTWATHTHNDLGMANANALAGIMHGATEIQGTINGIGERAGNVD 246 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 + E AI VR+ TAI ++ S +V+Q +MP+ NK I+G AFAH SGIH Sbjct: 247 IIEAAAAIYVRRQTFAKQTAIILEQSKHISDIVAQATHMPVAKNKPIMGRNAFAHESGIH 306 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 QDG LKN E YEI+ PE +G Q L L SG AV +++ +GY S ++ + F Sbjct: 307 QDGYLKNPETYEILRPEMVG-TQASLPLGKLSGSHAVMNQLLSLGYHISRQDMVTILPIF 365 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEE 387 ++A+K V D ++ + + + + Sbjct: 366 KRIAEKTSTVSDQQMQDMMTMIQTNKM 392 >UniRef50_Q57926 2-isopropylmalate synthase 1 n=16 Tax=Euryarchaeota RepID=LEU11_METJA Length = 398 Score = 405 bits (1042), Expect = e-111, Method: Composition-based stats. Identities = 145/388 (37%), Positives = 213/388 (54%), Gaps = 12/388 (3%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + + I+DTTLRDGEQ + ++KL+IA L+ +G+ +E GFP+ S + + V+TIA Sbjct: 22 KDIYIYDTTLRDGEQTPGVCFTKEQKLEIARKLDELGLKQIEAGFPIVSEREADIVKTIA 81 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKL-RSTLDEVIER 121 + N+ + AL R ++KDID A E + I TFIATSP+H+ K +LDE++E Sbjct: 82 NEGLNADILALCRALKKDIDKAIE----CDVDGIITFIATSPLHLKYKFNNKSLDEILEM 137 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 + V+ A+ + V FS EDA RTPI DL +V +AA AGA ++I DT G P Sbjct: 138 GVEAVEYAKEHGLFVAFSAEDATRTPIEDLIKVHKAAEEAGADRVHIADTTGCATPQSME 197 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 I L E N+ KA I VH H+D G AV NS+ + GA+ V +NGIGERAGN +L Sbjct: 198 FICKTLKE---NLKKAHIGVHCHNDFGFAVINSIYGLIGGAKAVSTTVNGIGERAGNAAL 254 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EE+IMA+ V D V +N + + ++V + + +P NK IVG FAH SGIH Sbjct: 255 EELIMALTVLYD---VDLGLNLEVLPELCRMVEEYSGIKMPKNKPIVGELVFAHESGIHV 311 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 D V++N YE PE IGL + + L SG AV +++ MG L + Sbjct: 312 DAVIENPLTYEPFLPEKIGLKRN-ILLGKHSGCRAVAYKLKLMGIDYDREMLCEIVKKVK 370 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPE 389 ++ ++ + D + + ++ Sbjct: 371 EIREEGKFITDEVFKEIVEEVLRKRNKN 398 >UniRef50_D1PA75 (R)-citramalate synthase n=1 Tax=Prevotella copri DSM 18205 RepID=D1PA75_9BACT Length = 532 Score = 404 bits (1038), Expect = e-111, Method: Composition-based stats. Identities = 130/518 (25%), Positives = 226/518 (43%), Gaps = 20/518 (3%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALAL-ERMGVDVMEVGFPVSSPGDFESVQTI 61 +++ I D TLRDGEQ S EKL IA L + VD +EV S G+ ++V I Sbjct: 13 KEIEIMDCTLRDGEQTNGVSFLPHEKLMIARMLLHDINVDRIEVASARVSEGEKDAVARI 72 Query: 62 ARQVKN-SRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 R K ++ ++ D + + + + I+ S H +L+ + +E + Sbjct: 73 CRYAKTIGKLDSVEVLGFVDNNKSVDWIAECGGHVINLLAKGSYKHCTQQLKMSPEEHLA 132 Query: 121 RAIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTVGYTMP 177 + A + V ED R L +++ + +PDT+G P Sbjct: 133 HIKQTIGYALSKGFTVNLYLEDWSSGMRDSRDYLFMMMDELVKQPIKRFLLPDTLGILNP 192 Query: 178 FEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 + + + R PN + H H+D LAV NSLAAV +GA+ + +NG+GER G Sbjct: 193 LQCVEYMRQMVRRYPN---SHFDFHAHNDYDLAVSNSLAAVLSGAKGLHVTVNGLGERCG 249 Query: 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 N L V + + KD+ T I + S+LV + + N +VG F + Sbjct: 250 NAPLASVQVIL---KDMFEAKTNIKEDRLNDISRLVEGYSGIAVAPNTPVVGDNVFTQVA 306 Query: 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 G+H DG K++ + PE G ++ + L SG+A + ++E+G + + + Sbjct: 307 GVHADGDNKDKLYCNDLVPERFGRHR-EYALGKNSGKANIVQNLNELGLELTPEQTKAVT 365 Query: 358 DAFLKLADKKGQVFDYDLEALA-FIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGE 416 +L D+K V DL + + K + +L + V + A+VK+ Sbjct: 366 KRITELGDRKELVTQDDLPYIVSDVLKHGAPEDKVKLVSYMVSTSYGLKPIASVKVEIEG 425 Query: 417 EVKAEAANGNGPVDAVYQAINRITEYNV-----ELVKYSLTAKGHG-KDALGQVDIVANY 470 + + ++G+G DA +A+ I + + +L Y +T G DAL Q I Sbjct: 426 KEYEDQSSGDGQYDAFVKALRNIYKVKLGKTFPKLDNYQVTIPPGGRTDALVQTVITWRE 485 Query: 471 NGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKE 508 R + GL D E++ KA + ++N ++ A + + + Sbjct: 486 GDRIWRTRGLDADQTEAAIKATLKMIN-MYEADKSDDQ 522 >UniRef50_P74269 Uncharacterized AIPM/Hcit synthase family transferase sll1564 n=103 Tax=cellular organisms RepID=LY41_SYNY3 Length = 547 Score = 402 bits (1033), Expect = e-110, Method: Composition-based stats. Identities = 135/524 (25%), Positives = 241/524 (45%), Gaps = 33/524 (6%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 + ++DTTLRDG Q SLS+ +KL IA L+++G+ +E G+P ++P D + + Sbjct: 7 SLWLYDTTLRDGAQREGISLSLTDKLTIARRLDQLGIPFIEGGWPGANPKDVQFFWQLQE 66 Query: 64 Q-VKNSRVCALARCVEK----DIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEV 118 + ++ + + A + D +++ A + F + +H+ L+++L E Sbjct: 67 EPLEQAEIVAFCSTRRPHKAVETDKMLQAILSAGTRWVTIFGKSWDLHVLEGLQTSLAEN 126 Query: 119 IERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGYT 175 + + R+ V + E D R + A AGA + + DT G T Sbjct: 127 LAMISDTIAYLRSQGRRVIYDAEHWFDGYRANPDYALATLATAQQAGAEWLVMCDTNGGT 186 Query: 176 MPFEFAGIISGLYERVP----NIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNG 231 +P + + I + + + + + + +H H+D G AV NSL AV AGA V+G +NG Sbjct: 187 LPGQISEITTKVRRSLGLDGQSDRQPQLGIHAHNDSGTAVANSLLAVEAGATMVQGTING 246 Query: 232 IGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSG 291 GER GN +L +I ++++ D + + TS+L+S+I N+ + VG Sbjct: 247 YGERCGNANLCTLIPNLQLKLDYDCIEPE-KLAHLTSTSRLISEIVNLAPDDHAPFVGRS 305 Query: 292 AFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEY 351 AFAH GIH V +N YE + P +G N+ ++ ++ ++G + V + + G Sbjct: 306 AFAHKGGIHVSAVQRNPFTYEHIAPNLVG-NERRIVVSEQAGLSNVLSKAELFGIALDRQ 364 Query: 352 N-LDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQ--EEPEHFRLDYFSVQSGSNDIAT- 407 N A LK +++G F+ + + +Q + F + F V A Sbjct: 365 NPACRTILATLKDLEQQGYQFEAAEASFELLMRQAMGDRQPLFLVQGFQVHCDLLTPAEN 424 Query: 408 -------AAVKLACGEEVKAEAANGNGPVDAVYQAINRITEY------NVELVKYSLTAK 454 A VK+ + E A GNGPV A+ QA+ + + L Y + Sbjct: 425 PAYRNALATVKVTVNGQNILEVAEGNGPVSALDQALRKALTRFYPQIADFHLTDYKVRIL 484 Query: 455 --GHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVL 496 G G A +V + ++ RR+ VG++ +I+E+S +A+V + Sbjct: 485 DGGAGTSAKTRVLVESSNGDRRWTTVGVSGNILEASYQAVVEGI 528 >UniRef50_C6VV54 Pyruvate carboxyltransferase n=32 Tax=Bacteria RepID=C6VV54_DYAFD Length = 520 Score = 400 bits (1029), Expect = e-110, Method: Composition-based stats. Identities = 144/509 (28%), Positives = 229/509 (44%), Gaps = 17/509 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIAL-ALERMGVDVMEVGFPVSSPGDFESVQT 60 S+ + I DTTLRDGEQ S S EKL IA L+ + VD +EV S G+F++V+ Sbjct: 3 SRYIEIMDTTLRDGEQTSGVSFSASEKLTIAQILLQEVKVDRIEVASARVSEGEFQAVKK 62 Query: 61 IARQVK-NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 I N + + D D + + A A ++ S H+ +L+ + + Sbjct: 63 ITDWAGANGFLDKIEVLTFVDGDASINWMVQAGARVMNLLTKGSLNHLTHQLKKSPEAHF 122 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTVGYTM 176 E +V+ A ED R+ + + ++ I +PDT+G Sbjct: 123 EDIRNVVELAEKNGIQCNVYLEDWSNGMRSSKEYVFQSLDFLSTLPVKRILLPDTLGILT 182 Query: 177 PFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERA 236 PFE I + +R P+ H H+D L V N + A+ AG + + +NG+GER Sbjct: 183 PFESYTFIKEIVDRYPD---QHFEFHGHNDYDLGVANVMEALRAGVQGLHLTVNGMGERT 239 Query: 237 GNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHS 296 GN L I I TA+N + ++ S+LV + IPANK IVG F + Sbjct: 240 GNAPLASTIAVINDLM--PECTTAVNEKSLYSISKLVETFSGIRIPANKPIVGESVFTQT 297 Query: 297 SGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNL 356 +GIH DG KN + + PE G ++ L SG+A +++ + ++G S+ +L + Sbjct: 298 AGIHADGDKKNNLYFSKLMPERFGRQRL-YALGKTSGKANIENNLRDLGISLSDADLKKV 356 Query: 357 YDAFLKLADKKGQVFDYDLE-ALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACG 415 ++L D+K V DL ++ I E + + + N +A ++++ G Sbjct: 357 TQRIIELGDRKEVVTPEDLPYIISDILDSDAIEEKVVITNYVLTHSKNLKPSATLQISFG 416 Query: 416 EEVKAEAANGNGPVDAVYQAINRITEYN----VELVKYSLTAKGHG-KDALGQVDIVANY 470 EEV E A G+G DA A+ +I + L Y++ G DAL + I Sbjct: 417 EEVFEENAQGDGQYDAFMNALKKIYKKKGIELPMLSDYTVRIPPGGKTDALCETIITWEI 476 Query: 471 NGRRFHGVGLATDIVESSAKAMVHVLNNI 499 NG+ GL +D S+ KA +LN I Sbjct: 477 NGKEIKTRGLDSDQTFSAIKATQKMLNLI 505 >UniRef50_B9KY22 2-isopropylmalate synthase/homocitrate synthase family protein n=4 Tax=Bacteria RepID=B9KY22_THERP Length = 562 Score = 395 bits (1015), Expect = e-108, Method: Composition-based stats. Identities = 148/518 (28%), Positives = 245/518 (47%), Gaps = 31/518 (5%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESV-QTI 61 ++V+I+DTTLRDG Q SL+ ++KL+IA AL+ +GV +E G+P S+P D + Sbjct: 30 RRVVIYDTTLRDGTQGSGVSLTTEDKLKIARALDELGVAYIEGGWPGSNPKDMAFFERAR 89 Query: 62 ARQVKNSRVCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 +Q +++R+ A DV L AE + SP + L +TLDE Sbjct: 90 HQQWRHARITAFGSTRRAGGTVEEDVNLRLLLEAETPAVTIVGKASPFQVRVILGTTLDE 149 Query: 118 VIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGY 174 + V + +V F E D V+ AA +AGA + + DT G Sbjct: 150 NLRMVAESVAFLKAAGREVIFDAEHFFDGYAEDPDYALAVLRAACDAGADAVVLCDTNGG 209 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 T+ ++ + + ++ + +HTH+D LAV N++AAV AGA V+G MNG+GE Sbjct: 210 TL---TDPLVRAVRHALSSV-SCTVGIHTHNDCELAVANTIAAVLAGAMHVQGTMNGLGE 265 Query: 235 RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFA 294 R GN +L +I ++ + + N +++ TS+ V+++ N+ VG+ AF Sbjct: 266 RIGNANLCSIIPILEYKLGYRCLPPG-NLRKLTETSRYVAEVANLAHDPRLPFVGAFAFT 324 Query: 295 HSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESE--YN 352 H +G+H + + K+ YE + PE +G + L + SGR+ + + G + + Sbjct: 325 HKAGLHVNAIAKHPSAYEHIPPEVVGNTRHVLV-SELSGRSNIVVKARSFGIELGDKPEV 383 Query: 353 LDNLYDAFLKLADKKGQVF---DYDLEALAFIGKQQEEPEHFRLDYFSVQ---SGSNDIA 406 + + + +L + G F D LE L P LDY + +G +A Sbjct: 384 VRRVLEQIKEL-EFHGYWFEDADASLELLIRRNLPDYRPPFEVLDYTVLTEYRNGRGMLA 442 Query: 407 TAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEY------NVELVKYSLTAKG--HGK 458 A VKL G+ V AA GNGPV+A+ +A + + V+L Y + HG Sbjct: 443 EAMVKLRIGQHVFHTAAEGNGPVNALDRATRKALQEFYPEIAAVDLEDYKVRVLDDHHGT 502 Query: 459 DALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVL 496 A +V I + ++ VG + +I+E+S A+ L Sbjct: 503 GAKVRVWIRSGDAHGSWNTVGSSENIIEASWLALADSL 540 >UniRef50_Q02CM5 2-isopropylmalate synthase n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q02CM5_SOLUE Length = 536 Score = 395 bits (1015), Expect = e-108, Method: Composition-based stats. Identities = 138/516 (26%), Positives = 245/516 (47%), Gaps = 29/516 (5%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 ++ FDTTLRDG Q S SV +KL IA L+ +G+D +E G+P S+P D + Sbjct: 2 KIFTFDTTLRDGTQGESISFSVDDKLIIAQKLDDLGIDYIEGGWPGSNPKDKDFFARSGE 61 Query: 64 Q-VKNSRVCALARCV----EKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEV 118 +K+S++ A + D ++L A + F + +H+ L +L+E Sbjct: 62 LNLKHSKLTAFGSTRFAKNPVEEDRNVKALVEAGTPVVSIFGKSWDLHVRRALGISLEEN 121 Query: 119 IERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGYT 175 + V + +V + E D R +EAA AGA+ + + DT G T Sbjct: 122 LVLISDTVGYIHGHGREVVYDAEHFFDGYTADPDYALRTLEAAHKAGASVLCLCDTNGGT 181 Query: 176 MPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGER 235 + I++ + +R I I +HTH+D LAV N++AAV AGA V+G MNG GER Sbjct: 182 VTGRLVEIVAEVRKRFDGI----IGIHTHNDGDLAVANTIAAVEAGATHVQGCMNGYGER 237 Query: 236 AGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAH 295 GN +L VI ++++ V + T + ++++ N+P+ ++ VG AFAH Sbjct: 238 CGNANLASVIANLELKLGHTTVGPE-KLAGLSSTCRFIAELANLPLRNDQPFVGKSAFAH 296 Query: 296 SSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKES-EYNLD 354 G+H VLK+ YE + PE++G N+ ++ ++ SGR + +++ + G + E + Sbjct: 297 KGGVHVSAVLKDSATYEHIKPEAVG-NRQRVLVSDLSGRGNIIYKLKQHGLADRLEEDTR 355 Query: 355 NLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEP--EHFRLDYFSVQS----GSNDIATA 408 + +K + +G + + ++ P F ++ + V + + +TA Sbjct: 356 RVLLERIKQMEYEGYELEAAEGTFELLVREALHPGMHFFDVESYEVSTRAAGNAASHSTA 415 Query: 409 AVKLACGEEVKAEAANGNGPVDAVYQAINRITE------YNVELVKYSLTAK--GHGKDA 460 V L + V + G+GP DA+ + + +V L Y + G A Sbjct: 416 TVTLKSQDGVHSATETGHGPFDALQVCLRKCLSKLYPQIVDVRLTDYKVRVLDTNKGTAA 475 Query: 461 LGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVL 496 +V I + + R + VG++ +++E+S KA+V + Sbjct: 476 NVRVLIEWSDHRRSWSTVGVSDNVIEASWKALVDAI 511 >UniRef50_A6C4F8 2-isopropylmalate synthase n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C4F8_9PLAN Length = 406 Score = 394 bits (1012), Expect = e-108, Method: Composition-based stats. Identities = 143/363 (39%), Positives = 209/363 (57%), Gaps = 2/363 (0%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V+ DTTLRDGEQ A+L EKLQIA ALE GV ++ GFP SS D +++Q++ Sbjct: 30 VLFSDTTLRDGEQMPGATLDPIEKLQIAKALEAAGVHSLDAGFPASSQADIDAIQSMVGV 89 Query: 65 VKNSRVCALARCVEKDIDVAAESLKV--AEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 +K + AL R + D+D A E+L + F TSP+H KL + EV++ Sbjct: 90 IKKPVLTALCRTLPGDVDAADEALAGNPPHKRGVSLFCGTSPLHRQFKLEKSKSEVLKLI 149 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + ++ A D V FS EDA RT + L V AI AGATTI PDTVG P++ Sbjct: 150 VDSIQYAAEKFDIVAFSPEDASRTEVDFLCEVYREAIAAGATTIGFPDTVGILTPWKAQD 209 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I + + VP I+ +++VH H+DLGLAV N+LA + AGA V+ +NGIGERAGN +LE Sbjct: 210 FICRIQDEVPGIENVLLAVHFHNDLGLAVANTLACIDAGANVVQCTVNGIGERAGNAALE 269 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV MA+ + ++ ++ ++ +LV+++ + + K + GS FA +GIHQD Sbjct: 270 EVAMALHLHQEEYQRPHQLDVSQLAPLCKLVAELTGIALSPMKPVAGSNIFATEAGIHQD 329 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G+LKN + Y PE++G I+L L SGR A+ HR+ E+G + +E + + A + Sbjct: 330 GLLKNPDTYLPYRPETVGETGIRLVLGRHSGRKAILHRLHELGKEPNEQVVQRVLQAIKE 389 Query: 363 LAD 365 L Sbjct: 390 LPK 392 >UniRef50_Q3M862 2-isopropylmalate synthase n=4 Tax=Bacteria RepID=Q3M862_ANAVT Length = 577 Score = 394 bits (1012), Expect = e-108, Method: Composition-based stats. Identities = 139/557 (24%), Positives = 247/557 (44%), Gaps = 65/557 (11%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 S + ++DTTLRDG Q S+S ++KL+IA L+++G+ +E G+P ++P D + + Sbjct: 6 SPHIWLYDTTLRDGTQREGLSISTEDKLRIAHRLDQLGIPFIEGGWPGANPKDVQFFWQL 65 Query: 62 ARQVKN-SRVCALARCVEKDIDVAAE----SLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 S++ A A E + A + + F + +H+ T L++TL+ Sbjct: 66 QEDPLKLSQIVAFCSTRRPHTHAADEPMLQDILAAGSSWVTIFGKSWDLHVTTGLKTTLE 125 Query: 117 EVIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVG 173 E + ++ R+ V + E D + + ++AA+ AGA + + DT G Sbjct: 126 ENLAMIRDTIEFFRSQGRRVIYDAEHWFDGYKHNRDYALQTLKAAMAAGAEWLVLCDTNG 185 Query: 174 YTMPFEFAGIISGLYER-----------------------------------VPNIDKAI 198 T+P E + I+ + + +PN+ I Sbjct: 186 GTLPHEVSQIVQDVVKVTRDWGRINSKLDQSGQVVSEEVEKSTNSLPNTQYPIPNLPFPI 245 Query: 199 --ISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILN 256 I +HTH+D +AV N+LAAV AGA V+G +NG GER GN +L +I ++++ Sbjct: 246 PQIGIHTHNDSDMAVANALAAVMAGATMVQGTINGYGERCGNANLCSLIPNLQLKLGYSC 305 Query: 257 VHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTP 316 + ++ S+ VS++ N+ + VG AFAH GIH V +N YE + P Sbjct: 306 ITEH-QLGQLAEASRFVSEVVNLAPDEHAPFVGRSAFAHKGGIHVSAVERNPLTYEHIQP 364 Query: 317 ESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEY--NLDNLYDAFLKLADKKGQVFDYD 374 E +G N+ ++ ++ +SG + V + G + + + +L + +G F+ Sbjct: 365 EQVG-NRRRIVISEQSGISNVLAKARTFGIELDKQTPEAKQILQRLKEL-ESEGYQFEAA 422 Query: 375 LEALAFIGKQQ--EEPEHFRLDYFSVQSG-----SNDIATAAVKLACGEEVKAEAANGNG 427 + A + + + F + F V A A VK+A + EAA GNG Sbjct: 423 EASFALLMYEALGGRQQFFEVKGFQVHCDLVEGKEMTNALATVKVAVNGKNILEAAEGNG 482 Query: 428 PVDAVYQAINRITE------YNVELVKYSLTAKGH--GKDALGQVDIVANYNGRRFHGVG 479 PV A+ A+ + EL Y + G A + + + +R+ VG Sbjct: 483 PVAALDAALRKALVNFYPQLATFELTDYKVRILDGHTGTSAKTRALVESGNGYQRWTTVG 542 Query: 480 LATDIVESSAKAMVHVL 496 ++ +I+ +S +A+V L Sbjct: 543 VSPNILAASYQAVVEGL 559 >UniRef50_A8ZTR1 2-isopropylmalate synthase/homocitrate synthase family protein n=3 Tax=Bacteria RepID=A8ZTR1_DESOH Length = 542 Score = 393 bits (1011), Expect = e-108, Method: Composition-based stats. Identities = 145/527 (27%), Positives = 246/527 (46%), Gaps = 37/527 (7%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +QV I+DTTLRDG Q + +V EK+++A L+ +GV +E G+P S+P D + + A Sbjct: 2 EQVRIYDTTLRDGMQGDTINFTVDEKIRVARQLDDLGVHYIEGGWPGSNPRDVQFFEKAA 61 Query: 63 R-QVKNSRVCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + KN+R+ A + D L A + T +HI + +TL+ Sbjct: 62 KIDFKNARLTAFGSTRRAGLAVEKDDNIRLLLECGAPAVALVGKTWDLHITEVMSNTLES 121 Query: 118 VIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGY 174 +E V +++ +V F E D + + A AGA + + DT G Sbjct: 122 NLEMIHDSVAYVKSHGREVFFDAEHFFDGCTHNREYTFKAILTAAQAGADAVILCDTNGG 181 Query: 175 TMPFEF----AGIISGLYERVPNIDK---AIISVHTHDDLGLAVGNSLAAVHAGARQVEG 227 +P + A + + L +R P D + +HTH+D LAV NS+AA+ AGAR V+G Sbjct: 182 ALPHDVEAITAEVCTTLADRFPGPDGGSTVQVGIHTHNDSNLAVANSIAAIRAGARIVQG 241 Query: 228 AMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAI 287 +NG GER GN L +I + + + + T N +++ + S+ VS+ NM ++ Sbjct: 242 TINGYGERCGNADLTSIIPILAAKMEYDCI-TPENLKKLRKVSRFVSETANMTPVNSRPF 300 Query: 288 VGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK 347 VG AF+H G+H ++KN YE M PE +G N+ ++ ++ SGR+ V ++ E+G Sbjct: 301 VGKSAFSHKGGLHVSAIMKNPRAYEHMDPELVG-NKRRVLISDLSGRSNVTYKARELGIN 359 Query: 348 ESEY--NLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQE--EPEHFRLDYFSV----Q 399 ++D + K+ + +G FD + + ++ F L F V + Sbjct: 360 TDTEHFDVDRILSEV-KMLELEGFQFDAADGSFKIVMEKISGLYTPLFDLLSFRVTVEKE 418 Query: 400 SGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEY---------NVELVKYS 450 A A ++L GE AA G+GPV A+ A+ ++LV + Sbjct: 419 KDRPCTAHATIRLGVGELETTTAAEGDGPVSALDTALRMAIAEFYPDSLGLDAMQLVDFK 478 Query: 451 LTAKGH--GKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHV 495 + G A +V I + + +G++ DI+E+S +A+ Sbjct: 479 VRVLDGRDGTSAKVRVLIDSRDEDEVWGTIGVSEDIIEASWEALADS 525 >UniRef50_P06208 2-isopropylmalate synthase n=109 Tax=cellular organisms RepID=LEU1_YEAST Length = 619 Score = 392 bits (1007), Expect = e-107, Method: Composition-based stats. Identities = 129/548 (23%), Positives = 219/548 (39%), Gaps = 47/548 (8%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQ- 59 +++ T LRDG Q+L +SV++K + L +G +EV FP +S DF+ + Sbjct: 57 ITRAPRWLSTDLRDGNQSLPDPMSVEQKKEYFHKLVNIGFKEIEVSFPSASQTDFDFTRY 116 Query: 60 TIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + + + L + E I E+L A+ IHT++ATS M + +E I Sbjct: 117 AVENAPDDVSIQCLVQSREHLIKRTVEALTGAKKATIHTYLATSDMFREIVFNMSREEAI 176 Query: 120 ERAIYMVKRARNYTDD----------VEFSCEDAGRTPIADLARVVEAAINAGATT---- 165 +A+ K R T D EFS E TP + EA A T Sbjct: 177 SKAVEATKLVRKLTKDDPSQQATRWSYEFSPECFSDTPGEFAVEICEAVKKAWEPTEENP 236 Query: 166 --INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGAR 223 N+P TV P +A I + +K IS H H+D G V + + AGA Sbjct: 237 IIFNLPATVEVASPNVYADQIEYFATHITEREKVCISTHCHNDRGCGVAATELGMLAGAD 296 Query: 224 QVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 +VEG + G GER GN L V M + + V ++ ++ +V + +P+ Sbjct: 297 RVEGCLFGNGERTGNVDLVTVAMNMYTQG----VSPNLDFSDLTSVLDVVERCNKIPVSQ 352 Query: 284 NKAIVGSGAFAHSSGIHQDGVLKN---------------RENYEIMTPESIGLN-QIQLN 327 G SG HQD + K R Y + P+ IG + + + Sbjct: 353 RAPYGGDLVVCAFSGSHQDAIKKGFNLQNKKRAQGETQWRIPYLPLDPKDIGRDYEAVIR 412 Query: 328 LTSRSGRAAVKH-RMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAF---IGK 383 + S+SG+ + +G A AD G+ D + F Sbjct: 413 VNSQSGKGGAAWVILRSLGLDLPRNMQIEFSSAVQDHADSLGRELKSDEISKLFKEAYNY 472 Query: 384 QQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYN 443 E+ + L ++V+ + ++ G+++ GNGP+ ++ A++ + Sbjct: 473 NDEQYQAISLVNYNVEKFGTERRVFTGQVKVGDQIVDIEGTGNGPISSLVDALSNLLNVR 532 Query: 444 VELVKYSLTAKGHGKDALGQVDIVAN-----YNGRRF-HGVGLATDIVESSAKAMVHVLN 497 + Y+ + G G I + N + + GVG++ D+ +SS +A+ +N Sbjct: 533 FAVANYTEHSLGSGSSTQAASYIHLSYRRNADNEKAYKWGVGVSEDVGDSSVRAIFATIN 592 Query: 498 NIWRAAEV 505 NI + +V Sbjct: 593 NIIHSGDV 600 >UniRef50_Q12166 2-isopropylmalate synthase 2, mitochondrial n=8 Tax=cellular organisms RepID=LEU9_YEAST Length = 604 Score = 390 bits (1002), Expect = e-107, Method: Composition-based stats. Identities = 133/547 (24%), Positives = 217/547 (39%), Gaps = 48/547 (8%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQ-TI 61 + T LRDG Q+L +SV +K + L +G +EV FP +S DF+ + + Sbjct: 58 KAPRWLSTDLRDGNQSLPDPMSVAQKKEYFHKLINIGFKEIEVSFPSASQTDFDFTRYAV 117 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 + + L + E I E+L A+ IHT++ATS M + +E I + Sbjct: 118 ENAPDDVGIQCLVQSREHLIKRTVEALTGAKRATIHTYLATSDMFREIVFNMSREEAISK 177 Query: 122 AIYMVKRARNYTDD----------VEFSCEDAGRTPIADLARVVEAAINAGATT------ 165 A+ K R T D EFS E TP + EA A T Sbjct: 178 AVEATKLVRKLTKDDPSQQATRWSYEFSPECFSDTPGEFAVEICEAVKKAWEPTEENPII 237 Query: 166 INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQV 225 N+P TV P +A I + +K IS H H+D G V + + AGA +V Sbjct: 238 FNLPATVEVASPNVYADQIEYFSTHITEREKVCISTHCHNDRGCGVAATELGMLAGADRV 297 Query: 226 EGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANK 285 EG + G GER GN L V M + + V ++ ++ S++V + +PIP Sbjct: 298 EGCLFGNGERTGNVDLVTVAMNMYTQG----VSPNLDFSDLTSISEIVHRCNKIPIPPRA 353 Query: 286 AIVGSGAFAHSSGIHQDGVLKN---------------RENYEIMTPESIGLN-QIQLNLT 329 G + SG HQD + K R Y + P+ IG + + + + Sbjct: 354 PYGGELVVSAFSGSHQDAIKKGFAIQNKKQAQGETRWRIPYLPLDPKDIGRDYEAVIRVN 413 Query: 330 SRSGRAAVKH-RMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAF---IGKQQ 385 S+SG+ M +G + + K AD G+ + F Sbjct: 414 SQSGKGGAAWVIMRSLGLDVPRPMQVDFSNTLQKNADALGRELKSEEITKLFKETYNYNN 473 Query: 386 EEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVE 445 E + L + V+ + + ++ ++V GNGP+ ++ A++ + + Sbjct: 474 NEHIYVTLLNYEVKKLNPERRALVGQVEINDKVVNIEGYGNGPISSLVDALSNLLNVKLS 533 Query: 446 LVKYSLTAKGHGKDALGQVDIVA-------NYNGRRFHGVGLATDIVESSAKAMVHVLNN 498 + YS + G G I N+ GVG++ D ++S KA+ +NN Sbjct: 534 VQNYSEHSLGSGSATQAASFINLSYIKDINNHATSNMWGVGVSEDTGDASIKAVFATVNN 593 Query: 499 IWRAAEV 505 I + +V Sbjct: 594 IIHSGDV 600 >UniRef50_D1AJT6 2-isopropylmalate synthase/homocitrate synthase family protein n=4 Tax=Bacteria RepID=D1AJT6_SEBTE Length = 529 Score = 390 bits (1002), Expect = e-107, Method: Composition-based stats. Identities = 143/517 (27%), Positives = 253/517 (48%), Gaps = 30/517 (5%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 +V +FDTTLRDG QA S SVK+K+ + AL+ G+D +E G P S+P D E + + Sbjct: 3 KVEVFDTTLRDGAQARGISFSVKDKIAVTQALDAFGIDYIEAGNPGSNPKDLEFFELVKS 62 Query: 64 -QVKNSRVCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEV 118 ++K+S++ A KD+ D SL A + F + H+ +++TL+ Sbjct: 63 VELKHSKLVAFGSTRRKDVAPEEDQNLISLLQAGTEYVSIFGKSWDFHVTDIIKTTLENN 122 Query: 119 IERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGYT 175 +E + ++ V F E D + ++AA + GA + + DT G Sbjct: 123 LEMIKDTLLFLKSKGKKVIFDAEHFFDGYKNNPEYALEALKAAKDGGAEILTLCDTNGGC 182 Query: 176 MPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGER 235 P E + I + E++ +I I +H H+D+G V NS+AAV AGA QV+G G GER Sbjct: 183 FPEEISRITKEVKEKLGDI---KIGIHAHNDMGFGVANSIAAVEAGALQVQGTFLGYGER 239 Query: 236 AGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAH 295 GN +L +I ++++KD + + T++++++I N+ I + +G AFAH Sbjct: 240 CGNANLSTIIANLQLKKD-YELVPREKLGLLTSTARIIAEISNITIEDSMPYIGKNAFAH 298 Query: 296 SSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMD--EMGYKESEYNL 353 G+H DGV K ++E + PE +G N+ + L+ SGR+ + + + + Sbjct: 299 KGGMHIDGVSKASHSFEHINPELVG-NEREFLLSEVSGRSTILEEIRRVDKDIQRDSEAT 357 Query: 354 DNLYDAFLKLADKKGQVFDYDLEALAFIGKQQ--EEPEHFRLDYFSVQS---GSNDIATA 408 + + +L + +G F+ + ++ + F L YF V+ G +TA Sbjct: 358 AGIIERLKEL-EYQGYQFEGAKATFELVIRKYLGKYKPFFDLVYFDVKGNYIGKKYYSTA 416 Query: 409 AVKLACGEEVKAEAANGNGPVDAVYQAINRITEY------NVELVKYSLTAKGHGKDALG 462 VK+ ++++ A G+GPV+A+ QA+ E + L+ Y + ++A Sbjct: 417 VVKVKVKDQIELTVAEGDGPVNALDQALRIALERFYPELKEMHLIDYKVRVLKGEENATA 476 Query: 463 ---QVDIVANYNGRRFHGVGLATDIVESSAKAMVHVL 496 +V I + + +G++TDI+E+S A+V + Sbjct: 477 SKVRVLIESADAKNSWTTIGVSTDIIEASWIALVDSI 513 >UniRef50_D2QST1 Pyruvate carboxyltransferase n=1 Tax=Spirosoma linguale DSM 74 RepID=D2QST1_9SPHI Length = 506 Score = 390 bits (1002), Expect = e-107, Method: Composition-based stats. Identities = 135/516 (26%), Positives = 223/516 (43%), Gaps = 28/516 (5%) Query: 1 MSQQ-VIIFDTTLRDGEQALQASLSVKEKLQIALAL-ERMGVDVMEVGFPVSSPGDFESV 58 M ++ + I DTTLRDGEQ S S EKL +A L + VD +E+ S G+ E+V Sbjct: 1 MKRRYIEIMDTTLRDGEQTSGVSFSASEKLALAQLLLTEVKVDRVEIASARVSAGELEAV 60 Query: 59 QTIAR------QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLR 112 Q I R + V D + + L+ + A ++ S H+ +L+ Sbjct: 61 QQITRWADSIGLIDKVEVLTFV-----DGQASLDWLQASGAKVMNLLTKGSLNHLTHQLK 115 Query: 113 STLDEVIERAIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIP 169 T E +V A ED R + + ++ + +P Sbjct: 116 KTPGEHFTDIGQVVCAAGKLGVKANVYLEDWSNGMRNSPDYVFQYLDFLNTQPILRVLLP 175 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G P E + L R PN+ H H+D L++ N + A+ AGA + + Sbjct: 176 DTLGVLTPAESYSFVHQLVTRYPNL---HFDFHAHNDYDLSIANVMEAIRAGAHGIHLTV 232 Query: 230 NGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVG 289 NG+GERAGN L I + R + V T + + +++ S++V + IP NK +VG Sbjct: 233 NGLGERAGNAPLASAIAVL--RDFMPEVRTGVVEKSLYQVSKIVETFSGLRIPDNKPVVG 290 Query: 290 SGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKES 349 F ++GIH DG KN + + PE G + L SG+A +++ + E+G + S Sbjct: 291 DNVFTQTAGIHADGDKKNNLYFNALLPERFGRKR-SYALGKMSGKANIENNLRELGIQLS 349 Query: 350 EYNLDNLYDAFLKLADKKGQVFDYDLE-ALAFIGKQQEEPEHFRLDYFSVQSGSNDIATA 408 E +L + ++L D+K V DL ++ + + + + + +A Sbjct: 350 EDDLKKVTQRVIELGDQKEVVTREDLPYVISDVLNTNSFASRVEVLNYVLTHSKDLKPSA 409 Query: 409 AVKLACGEEVKAEAANGNGPVDAVYQAINRITEYN----VELVKYSLTAKGHG-KDALGQ 463 +++ EE E+A G+G DA A+ +I L Y++ G DAL + Sbjct: 410 TLRVRIDEEHFEESAQGDGQYDAFMNALKKIYVKKKLTLPLLTDYAVRIPTGGRTDALCE 469 Query: 464 VDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNI 499 I + F GL +D S+ KA +LN + Sbjct: 470 TIITWKHKNGEFKTRGLDSDQTVSAIKATQKMLNTL 505 >UniRef50_B3TC58 Putative HMGL-like protein n=1 Tax=uncultured marine microorganism HF4000_APKG10H11 RepID=B3TC58_9ZZZZ Length = 530 Score = 386 bits (991), Expect = e-105, Method: Composition-based stats. Identities = 127/527 (24%), Positives = 244/527 (46%), Gaps = 32/527 (6%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + + I DTTLRDG Q + +++EK+ IA L+ +GV+++E G+P S+P D E + I Sbjct: 9 KTIEILDTTLRDGSQMRGVNFTLQEKIMIATKLDDLGVNIIEGGWPGSNPKDLEFFKLIK 68 Query: 63 R-QVKNSRVCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + +++NS++ K+I D + + +EA TS H+ L +L++ Sbjct: 69 KHELRNSKIAVFGSTRRKNITAKNDNNLKVMVDSEALVSVIVGKTSSFHVEKILNCSLED 128 Query: 118 VIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGY 174 +E + R F E D + V+ A A TI + DT G Sbjct: 129 NLEMIYDSLIFLRESGLQTYFDAEHFFDGYNINPEYAIQTVKTAEEAKVNTIVLCDTNGG 188 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 +P + ++ + + + I H H+D G AV N+++AV AGA ++G +NG+GE Sbjct: 189 MLPHQIERVVKKIKKN----SEVKIGFHGHNDTGCAVANTVSAVVAGATHIQGTINGLGE 244 Query: 235 RAGNCSLEEVI----MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGS 290 R GN L +VI M +K + + IN ++ S ++++ N+ ++ G Sbjct: 245 RTGNADLCQVIPNLEMKLKKKTRNIQKKQIINFGKLRDISNYINELVNINSFDHQPYFGK 304 Query: 291 GAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMG--YKE 348 AF+H +G+H DG+LK+ + YE + PE ++ ++ SG+A + + + Sbjct: 305 FAFSHKAGLHVDGMLKSSKAYEHINPEIF-KSERSFTISELSGKANIIALSKKFNFQIDK 363 Query: 349 SEYNLDNLYDAFLKLADKKGQVFD--YDLEALAFIGKQQEEPEHFRLDYFSVQSG--SND 404 + + ++ + KL + G D L F+ ++F +D + V + + Sbjct: 364 DDKRIIDILEEIKKL-EFSGFTLDNADATTYLIFLRHLGLYKQYFHVDSWKVLTEKQNQI 422 Query: 405 IATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITE------YNVELVKYSLTAKGHGK 458 + + +K+ GE + A G GPV+++ A+ + + +EL Y ++ G K Sbjct: 423 NSKSEIKILIGENIYTNNAYGVGPVNSLAIALRKSLQNKYPEINKIELTNYKVSIVGASK 482 Query: 459 DA--LGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAA 503 D L +V I + + + +I+++S +A++ + + Sbjct: 483 DTASLVRVFIEFKKDEVVWATTATSQNILDASLRALIDGHDYFLQKN 529 >UniRef50_Q04TA5 2-isopropylmalate/homocitrate synthase n=14 Tax=Bacteria RepID=Q04TA5_LEPBJ Length = 516 Score = 385 bits (988), Expect = e-105, Method: Composition-based stats. Identities = 136/519 (26%), Positives = 224/519 (43%), Gaps = 25/519 (4%) Query: 1 MSQ---QVIIFDTTLRDGEQALQASLSVKEKLQIAL-ALERMGVDVMEVGFPVSSPGDFE 56 M++ ++ I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E Sbjct: 1 MTKAETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 Query: 57 SVQTIARQVKNSRVCALARCVE-KDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 +VQ I + ++ + D + + +K + A ++ S H+ +L T Sbjct: 61 TVQKIIEWAETEQLTERIEILGFVDGNKTVDWIKDSGARVLNLLTKGSLHHLEKQLNKTP 120 Query: 116 DEVIERAIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTV 172 E +++ A + ED R + +V+ I +PDT+ Sbjct: 121 KEFFADVSIVIEYAIKNGLKINVYLEDWSNGFRNSPDYVEALVKHLSKERIERIFLPDTL 180 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G P E + L ++ PN+ H H+D L+V NSL A+ AG + + +MNG+ Sbjct: 181 GVLSPEETFQGVDSLVQKYPNL---HFEFHGHNDYDLSVANSLQAIRAGVKGLHASMNGL 237 Query: 233 GERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 GERAGN LE ++ I D T IN I S+LV I AN+ IVG Sbjct: 238 GERAGNTPLEALVTTIH---DKSQAKTNINELAITEASRLVEVFSGKRISANRPIVGEDV 294 Query: 293 FAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYN 352 F ++G+H DG K + PE G + L SG+A++ + ++G S+ Sbjct: 295 FTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLSGKASISENVKQLGMVLSDIV 353 Query: 353 LDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKL 412 L + + ++L D+ V DL + + + + ++ SG A ++L Sbjct: 354 LQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGVRPHAQIEL 413 Query: 413 ACGEEVKAEAANGNGPVDAVYQAINRITEYN----VELVKYSLTAKGHG-KDALGQVDIV 467 +V E + G+G DA A+ +IT +L+ Y + G DAL + I Sbjct: 414 EYQGKVHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETMIT 473 Query: 468 AN-----YNGRRFHGVGLATDIVESSAKAMVHVLNNIWR 501 N + F +G+ D ++ A +LN I + Sbjct: 474 WNKSLDLEEDQTFKTMGVHPDQTIAAVHATEKMLNQILQ 512 >UniRef50_C1ZKW9 Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZKW9_PLALI Length = 418 Score = 385 bits (988), Expect = e-105, Method: Composition-based stats. Identities = 149/365 (40%), Positives = 214/365 (58%), Gaps = 2/365 (0%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 S ++++ DTTLRDGEQ A+L +EK +IALALE G+ ++ GFP SS DF++++ + Sbjct: 26 SGRIMLSDTTLRDGEQMPGATLEPEEKREIALALEAAGIHSLDAGFPASSQQDFDAIRLM 85 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVA--EAFRIHTFIATSPMHIATKLRSTLDEVI 119 A+ +K + AL R VE D+D A E+L + FI TSP+H KLR + EV+ Sbjct: 86 AQVIKRPVMTALCRTVEGDVDAADEALAGLAPHKRGVSLFIGTSPLHREYKLRKSRTEVL 145 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE 179 V+ A D V FS EDA RT L E AI AGATTI PDTVG P Sbjct: 146 SIIDRSVRYASKKFDIVAFSPEDASRTEADFLVECYETAIQAGATTIGYPDTVGVLTPER 205 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 I + E VP+I K +++VH H+DLGLAV NSLA + AGA V+ +NGIGERAGN Sbjct: 206 AYVAIRHVMEHVPSIRKVLVAVHMHNDLGLAVANSLAGLTAGAHIVQCTVNGIGERAGNA 265 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 +LEEV MA+ V ++ +N++ ++ QLV++ +P+ NK + G FA +GI Sbjct: 266 ALEEVAMALYVNQEQYGRAVKLNYESLFPLCQLVAKKTGVPMALNKPVAGRTIFATEAGI 325 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 HQDG+LK+ + Y PE +G I+L L SG+ AV H + +GY+ ++ ++ + + Sbjct: 326 HQDGLLKHPDTYLPYRPEVVGGPAIELVLGRHSGKGAVAHHLQNLGYQATDAHVMFILNQ 385 Query: 360 FLKLA 364 + Sbjct: 386 IKGMP 390 >UniRef50_A8L551 2-isopropylmalate synthase n=38 Tax=Bacteria RepID=LEU1_FRASN Length = 565 Score = 385 bits (988), Expect = e-105, Method: Composition-based stats. Identities = 129/538 (23%), Positives = 213/538 (39%), Gaps = 44/538 (8%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +++ LRDG QAL ++ K+Q+ L MG +EVGFP +S DF+ V+ Sbjct: 33 ITEAPRWCSVDLRDGNQALIDPMTPSRKMQLFELLVAMGYKEIEVGFPAASQTDFDFVRQ 92 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + + L + E+ I+ SL ++ IH + +TS + Sbjct: 93 LIEDDLIPDDVTIQVLTQAREELIERTVTSLVGSDRALIHLYNSTSTLQRRVVFGLDRAG 152 Query: 118 VIERAIYMVKRARNY------TDDVE--FSCEDAGRTPIADLARVVEAAINAGATT---- 165 V + A+ + Y DV +S E T + V EA ++ A T Sbjct: 153 VTDIAVQGARWCAQYAEKLLEGTDVRWQYSPESFTGTELDYALEVCEAVMDVWAPTPDNP 212 Query: 166 --INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGAR 223 +N+P TV + P +A I + + D ++S+H H+D G AV + V AGA Sbjct: 213 VVLNLPATVEMSTPNVYADQIEWMSRNLTRRDAVVLSLHPHNDRGCAVAAAELGVMAGAD 272 Query: 224 QVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 +VEG + G GER GN L + M + + + I+ +I + V +P+ Sbjct: 273 RVEGCLFGNGERTGNVCLVTLGMNLFSQG----IDPMIDLSDIDGVRRTVEYCNQLPVHP 328 Query: 284 NKAIVGSGAFAHSSGIHQDGVLKNRENYE------------IMTPESIGLN-QIQLNLTS 330 G + SG HQD + K E E + P+ +G + + + + S Sbjct: 329 RHPYGGDLVYTAFSGSHQDAIKKGFEAMERTGQTLWEVPYLPIDPKDVGRSYEAVIRVNS 388 Query: 331 RSGRAAVKHRMD-EMGYKESEYNLDNLYDAFLKLADK------KGQVFDYDLEALAFIGK 383 +SG+ V + M E K D GQ+++ G Sbjct: 389 QSGKGGVAYLMKSEYALDLPRRLQIEFSGVVQKHTDDAGGEVTAGQLWEIFTREYRPEGG 448 Query: 384 QQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYN 443 + SG+ D T +V+L +GNGP+DA A++ Sbjct: 449 DPAASLELLGSRTTAASGARDEVTVSVRL--DGTETVITGSGNGPIDAFVAALSE-RGVP 505 Query: 444 VELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWR 501 V ++ Y+ A G G DA + GVG+ +IV +S +A+V +N R Sbjct: 506 VRVLDYNEHALGSGADARAAAYLEVAVGETVLWGVGIDPNIVTASLRAVVSAVNRASR 563 >UniRef50_UPI000038E0F9 2-isopropylmalate synthase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0F9 Length = 388 Score = 384 bits (987), Expect = e-105, Method: Composition-based stats. Identities = 134/365 (36%), Positives = 207/365 (56%), Gaps = 17/365 (4%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + + IFDTTLRDGEQ S + +K +IA L GV+++E GFP S + +S++ I Sbjct: 28 ENISIFDTTLRDGEQTPGVSFNTDQKYKIAKMLYDAGVNIIEAGFPAVSNDEMKSIKKIN 87 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 ++N +C+LARC DID ES ++ IH FIATS +H+ KL+ T ++V + Sbjct: 88 HDMEN--ICSLARCNRNDIDKVIES----DSRIIHLFIATSDIHMKYKLKKTREQVFDSI 141 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + + AR+Y + FS EDA RT + L ++V + TIN PDT+G P Sbjct: 142 MESIDYARSYGMRIIFSPEDATRTSMDFLKQIVSSIK---VETINFPDTIGIMNPISMYY 198 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I+ + IS+H H+D G+A N+LA + AGA + + +NGIGERAGN SLE Sbjct: 199 FINKIKS----FTSTGISIHCHNDFGMATANTLAGLMAGANEAQVTVNGIGERAGNASLE 254 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV+ +I LN +T I ++++ S+ VS + NKAI G AF+H +GIH Sbjct: 255 EVVSSI---YGFLNSYTDIKMEKLYSISKYVSAASGIIPQKNKAITGENAFSHEAGIHVQ 311 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G++ N + YE + PE GLN+ ++ + SG+AA+K+ ++ G +++ +DN+ K Sbjct: 312 GIINNPKTYEAINPEIFGLNR-RIVIGKHSGKAAIKYILENNGMHKTDDEIDNILQIVKK 370 Query: 363 LADKK 367 +K Sbjct: 371 EGNKT 375 >UniRef50_Q6L0K4 2-isopropylmalate synthase n=1 Tax=Picrophilus torridus RepID=Q6L0K4_PICTO Length = 386 Score = 383 bits (984), Expect = e-105, Method: Composition-based stats. Identities = 138/361 (38%), Positives = 208/361 (57%), Gaps = 14/361 (3%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ IFDTTLRDGEQ+ S ++ +K +IA L +GVD++E GF S + +++ I Sbjct: 27 KRIRIFDTTLRDGEQSPGVSFNINQKARIAGMLVDLGVDMIETGFAAVSSEESMAIRKIH 86 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 N +LARC DID ++ IH FIATS +HI KL+++ + ++E+ Sbjct: 87 EMDGN--FISLARCNRHDIDSVIDT----GIDNIHLFIATSDIHIKYKLKTSRENIMEKI 140 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + + AR++ +V FS EDA RT + L V+ AI++GA INIPDT+G P Sbjct: 141 VDSIDYARSHGLNVLFSPEDATRTDMNFLIDVINTAISSGAYEINIPDTIGIMNPISMYN 200 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I + R K+ ISVH H+D G+A N+LAA+ AGA + +NGIGERAGN +LE Sbjct: 201 FIHEIKNR----TKSCISVHCHNDFGMATANTLAAIMAGADGAQVTVNGIGERAGNAALE 256 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV++++ D T IN + I + S+ VS M I NKAIVG AF+H SGIH Sbjct: 257 EVVLSVHAFTD---CSTGINMRMIPKISKYVSMASKMYIQKNKAIVGENAFSHESGIHVH 313 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G++ N E YE + P +GLN+ ++ L SG ++K+ ++ G K+S+ + + Sbjct: 314 GLINNPETYEPIDPGILGLNR-RIVLGKHSGTTSLKYILESHGIKKSDDEISGILVRIKD 372 Query: 363 L 363 + Sbjct: 373 M 373 >UniRef50_C8WRC1 2-isopropylmalate synthase n=14 Tax=Bacteria RepID=C8WRC1_ALIAD Length = 564 Score = 383 bits (983), Expect = e-104, Method: Composition-based stats. Identities = 126/531 (23%), Positives = 228/531 (42%), Gaps = 38/531 (7%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + I LRDG QAL ++++EKL L +G +EVGFP +S +FE V+T+ Sbjct: 29 RPPIWCSVDLRDGNQALIVPMNLEEKLAYFQLLVEIGFKEIEVGFPAASDTEFEFVRTLI 88 Query: 63 RQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + + + L + + I+ E+++ A+ +H + +TS R+ DE++ Sbjct: 89 ERDLVPSDVTIQVLTQSRDHIIERTFEAIRGAKRAIVHLYNSTSVAQREQVFRADKDEIV 148 Query: 120 ERAIYMVKRARNYT------DDVEFSCEDAGRTPIADLARVVEAAINAGATT------IN 167 A+ ++ R+ ++S E T + + A ++ T IN Sbjct: 149 NIAVTGAEQIRDLARTTPGNFFFQYSPESFTGTELDFALEICNAVLDVWKPTPDRKVIIN 208 Query: 168 IPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEG 227 +P TV +MP +A I + +R+ D ++SVH H+D G V + A+ AGA ++EG Sbjct: 209 LPATVELSMPHVYASQIEYMGKRLARRDAIVLSVHPHNDRGTGVAAAELAMLAGAERLEG 268 Query: 228 AMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAI 287 + G GER GN + + + + + ++ + V + M + Sbjct: 269 TLFGNGERTGNVDIVTLALNLYSHG----IDPGLDFSNLPAIQARVEALTKMQVSRRHPY 324 Query: 288 VGSGAFAHSSGIHQDGVLKNRENYE------------IMTPESIGLNQIQ--LNLTSRSG 333 G F SG HQD + K + E + P+ IG + + S+SG Sbjct: 325 AGELVFTAFSGSHQDAIAKGMKWREEKSPEHWTVPYLPIDPKDIGREYEGDIIRINSQSG 384 Query: 334 RAAVKHRMDE-MGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFR 392 + + + +++ G+ + L A +++D++ + D A F+ + + Sbjct: 385 KGGIGYVLEQSHGFDLPPKMREQLGYAVKRVSDREQKELSADEIAEIFMREFVNLGQPLD 444 Query: 393 LDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLT 452 L + A + GE V+ E A GNG +DA+ A+ V + Y Sbjct: 445 LVELTGTDARGSHRVRATVVWQGETVEIEGA-GNGRLDALCHALEEGLGIRVANLTYKEH 503 Query: 453 A--KGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWR 501 A G G A+ + + + G G G+ TDI+E+SAKA+V +N + Sbjct: 504 ALEVGSGSRAVAYISVD-DEEGNTHFGCGVDTDIMEASAKALVSAVNRMLA 553 >UniRef50_A5VPL4 2-isopropylmalate synthase/homocitrate synthase family protein n=151 Tax=Bacteria RepID=A5VPL4_BRUO2 Length = 640 Score = 381 bits (978), Expect = e-104, Method: Composition-based stats. Identities = 138/529 (26%), Positives = 243/529 (45%), Gaps = 36/529 (6%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ I+DTTLRDG+Q SV++K I LE +GVD +E G+P ++P D + Sbjct: 107 ERIYIYDTTLRDGQQTPGVDFSVEDKKSIVTLLEELGVDYVEGGYPGANPTDTAFFKR-- 164 Query: 63 RQVKNSRVCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEV 118 RQ ++ A + D SL A A + + H+ L T +E Sbjct: 165 RQTARAKFVAFGMTKRAGVSVSNDPGLSSLLQASADAVCFVAKSWDYHVRLALGCTNEEN 224 Query: 119 IERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGYT 175 +E V AR + CE D + +AA +AGA + + DT G T Sbjct: 225 LESITASVTAARMAGREALVDCEHFFDGYKANPEYALACAKAAYSAGARWVVLCDTNGGT 284 Query: 176 MPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGER 235 P E A I+ + VP + +H H+D AV SLAA+ AG R V+G +NGIGER Sbjct: 285 QPLEVAAIVEAVKAVVPG---ESLGIHAHNDTEQAVAVSLAAIDAGVRHVQGTLNGIGER 341 Query: 236 AGNCSLEEVIMAIKVRKDILNV----HTAINHQEIWRTSQLVSQICNMPIPANKAIVGSG 291 GN +L +I + ++ + + I R S+ I N P G+ Sbjct: 342 CGNANLVSLIPTLVLKPYWAERFELGIKPASLKSITRISRAFDDILNRPATEQAPYTGTS 401 Query: 292 AFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEY 351 AFA +GIH ++K + YE + PES+G N ++ ++ + G++ ++ G + ++ Sbjct: 402 AFATKAGIHASALMKEPQTYEHIPPESVG-NSRRVMVSDQGGKSNFIAELERRGIRVAKD 460 Query: 352 NLD-NLYDAFLKLADKKGQVFDYDLEALAFI--GKQQEEPEHFRLDY--------FSVQS 400 ++ + A +K + +G ++ + + G +PE F+++ F Sbjct: 461 DVRLDTLIALVKEREAEGYAYEGADASFELLARGMLNPQPEFFKVESFRCLVERRFDANG 520 Query: 401 GSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITE------YNVELVKYSLTAK 454 ++ A VK+ E+ A G+GPV+A+ A+ + ++ELV + + Sbjct: 521 MLKTVSEAVVKVEVDGEMHMSVAEGHGPVNALDIALRKDLGCFQAEIEDLELVDFKVRIL 580 Query: 455 GHGKDALGQVDIVANYN-GRRFHGVGLATDIVESSAKAMVHVLN-NIWR 501 G A+ +V I + G R+ VG++ +I+++S +A++ +N + + Sbjct: 581 NGGTAAITRVLIESGDATGARWRTVGVSDNIIDASFQALMDSVNYKLMK 629 >UniRef50_Q97MC5 2-isopropylmalate synthase n=50 Tax=Bacteria RepID=LEU1_CLOAB Length = 558 Score = 378 bits (971), Expect = e-103, Method: Composition-based stats. Identities = 126/538 (23%), Positives = 219/538 (40%), Gaps = 51/538 (9%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + I LRDG QAL ++V EK+++ L +G +E+GFP +S ++E + + Sbjct: 26 KAPIWCSVDLRDGNQALPKPMNVDEKIKMFKMLVDIGFKEIEIGFPSASETEYEFTRKLI 85 Query: 63 RQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 ++ + L + E + E+LK + +H + +TS + + DEV Sbjct: 86 EDKLIPEDVTIQVLTQAREHLVKKTFEALKGVKTAIVHVYNSTSELQRRVVFKKDKDEVK 145 Query: 120 ERAIYMVKRARNYTDD---------VEFSCEDAGRTPIADLARVVEAAINAGAT------ 164 AI + + Y++ E+S E T + V EA +N Sbjct: 146 SLAIKGAQMVKKYSEYTEYSESKFVFEYSPESFTGTELDYALEVCEAVLNVWKPSKENKA 205 Query: 165 TINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 IN+P TV P +A I +++ N + I+S+HTH+D G +S + AGA + Sbjct: 206 IINLPSTVEMATPNIYADQIEWFCKKLLNRESVILSLHTHNDRGTCTASSELGILAGADR 265 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 VEG + G GER GN IM + + V + + + + M + Sbjct: 266 VEGTLFGNGERTGNLD----IMNMALNMYSQGVDPELEFSNLNDIVEAYEECTKMVVHER 321 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNREN------------YEIMTPESIGLNQIQLN-LTSR 331 G F SG HQD + K ++ Y + P +G ++ + S+ Sbjct: 322 HPYAGKLVFTAFSGSHQDAIRKGLKSLKEGKNKHWEVPYLAVDPHDLGREYEEIIRINSQ 381 Query: 332 SGRAAVKHRMD-EMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEH 390 SG+ + M+ + G+ ++ F K+ KK D +L +EE Sbjct: 382 SGKGGTAYIMESDFGFILP----KAMHPEFGKVIKKKSDELDCELSPEQIFKFFKEEYLE 437 Query: 391 FRLDYF----------SVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRIT 440 R Y+ +++ N + AV G++ E GNGPVDA + A+N Sbjct: 438 NRSPYYLKNYKIHSIQNIEEEKNTVDIEAVISVNGKDTSIE-GVGNGPVDAFFNAMNNKK 496 Query: 441 EYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNN 498 + + Y A G + + +++ GVG++ +I +S A+V LN Sbjct: 497 YNGCKFISYDEHALNIGSHSKAVAYVQIESQDKKYFGVGISDNIDTASINAIVSALNR 554 >UniRef50_A4A2P3 2-isopropylmalate synthase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A4A2P3_9PLAN Length = 542 Score = 378 bits (971), Expect = e-103, Method: Composition-based stats. Identities = 141/539 (26%), Positives = 248/539 (46%), Gaps = 28/539 (5%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ I+DTTLRDG Q S S+++KL I L+ +GVD +E G+P+S+ D E + + Sbjct: 2 RKIEIYDTTLRDGAQGEGVSFSLQDKLSITERLDEIGVDFVEGGYPLSNEKDAEYFRRVQ 61 Query: 63 RQ-VKNSRVCALARCVEKDIDVAAE----SLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 +K+++VCA K I+ A + +L + A + T H+ LR TL+E Sbjct: 62 DLNLKHTKVCAFGMTRRKGINAADDPGMQALVSSGAPVVTIVGKTHDFHVTDVLRVTLEE 121 Query: 118 VIERAIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTVGY 174 + V +V + E + A + AA AGA + + DT G Sbjct: 122 NLAMIADSVAYIVGAGREVIYDAEHFFDGWKANPEYAAETIRAAAKAGARMVVMCDTNGG 181 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 ++P E A + + + +HTH+D LAV NSLAAV AGA QV+G +NG GE Sbjct: 182 SLPEEIAEYAAKAIAALTEF-NVPVGIHTHNDGDLAVANSLAAVDAGAVQVQGTINGFGE 240 Query: 235 RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFA 294 R GN L VI + +++ V +Q + S+ V N+ N+A VG AFA Sbjct: 241 RCGNADLISVIANLGLKRKGYEVIGGAGYQHLTELSRFVYDTANVNRRNNQAFVGQSAFA 300 Query: 295 HSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLD 354 H G+H + + +YE + P+S+G N+ ++ ++ SGR+ + + ++ +D Sbjct: 301 HKGGMHVHAINRAASSYEHIDPQSVG-NERRVLVSELSGRSNIVALTTKHNLQDDRELMD 359 Query: 355 NLYDAFLKLADKKGQVFDYDLEALAFIGKQQE--EPEHFRLDYFSVQSGS-------NDI 405 + + + +G F+ + + K+ HF + + V+ + + Sbjct: 360 KILAEVV-AKENQGFQFEAAEASFDLLVKRVAGVFEPHFEILKYHVEVEDLVEHKMVDLV 418 Query: 406 ATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITE------YNVELVKYSLTAKG--HG 457 A VK++ E++ E G+GPV A+ A+ + + LV Y + G Sbjct: 419 TEATVKVSVDGEIRYEVGEGDGPVQALDVALRKSLNGCFPTLEEMHLVDYKVRVVNQEAG 478 Query: 458 KDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHN 516 A +V I + + +G++ +I+++S A+V + E +L +A + Sbjct: 479 TAARIRVTIESADENDVWGTIGVSENIIQASWNALVDAIEYKLYKDEQRGKLPARASAD 537 >UniRef50_Q3A2Q7 Homocitrate synthase 1 n=18 Tax=Bacteria RepID=Q3A2Q7_PELCD Length = 400 Score = 375 bits (963), Expect = e-102, Method: Composition-based stats. Identities = 128/386 (33%), Positives = 189/386 (48%), Gaps = 13/386 (3%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 +II DTTLRDGEQ S++EK IA L+ +GV +E G P + SV+ + Sbjct: 8 DIIIDDTTLRDGEQTAGVVFSLEEKKTIARMLDDIGVQELECGIPAMGREEQRSVKALVD 67 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 ++R+ R + DI + + + ++ S +HI KLR V E+ Sbjct: 68 LGLHARLITWNRALVDDIRASLQ----CGVNAVDISLSVSDLHIRHKLRKDRHWVREQLK 123 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 + A+ + V EDA R + L ++E A + GA DT+G PF Sbjct: 124 RALGFAKQHDLYVSIGGEDASRADLDFLVELMELARSMGADRFRFCDTLGLLDPFVTFEK 183 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 I L +RV I VHTH+DLG+A N++A V AGAR + +NG+GERAGN +LEE Sbjct: 184 IRYLTQRV----DLDIEVHTHNDLGMATANAIAGVRAGARFINTTVNGLGERAGNAALEE 239 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 V+M + K V I+ S+ V N P+PA K +VG FAH SG+H DG Sbjct: 240 VVMGL---KHACGVKCPIDTSRFVEISRYVGAASNRPVPAWKPVVGERVFAHESGLHVDG 296 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 VLK+ NYE P +G +++ L L +GR + R+ +G + L L + Sbjct: 297 VLKDPRNYEPFEPHEVGSSRL-LVLGKHTGRHGLAARVKGLGLDPGDICLSTLLRRIRAI 355 Query: 364 ADKKGQ-VFDYDLEALAFIGKQQEEP 388 + ++ + V D +LE L Q +P Sbjct: 356 SQRRKRPVEDAELEGLYRSLAQASQP 381 >UniRef50_C9RKZ6 Pyruvate carboxyltransferase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RKZ6_FIBSS Length = 518 Score = 375 bits (963), Expect = e-102, Method: Composition-based stats. Identities = 171/527 (32%), Positives = 268/527 (50%), Gaps = 37/527 (7%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 +++ +D TLRDG QAL + +K + L L ++GV EVGFP SS DFESV + Sbjct: 4 TRKPFFYDVTLRDGNQALPKPWNNAQKKDVYLLLLKLGVQGAEVGFPASSEMDFESVMEL 63 Query: 62 ARQ-----------VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATK 110 A+ KN V LARC+E DI E+++ A RIHTF+ATSP+ + Sbjct: 64 AKLTAQMAEEGDEVAKNVVVSGLARCIESDIQRCWEAVQYAPHPRIHTFLATSPLSMENV 123 Query: 111 LRSTLDEVIERAIYMVKRARNYT---DDVEFSCEDAGRT--PIADLARVVEAAINAGATT 165 L T ++V E+A+ VK A++ DVEFS E G + + V++A + AGATT Sbjct: 124 LHMTPEQVKEKAVKCVKFAKSLVGDRGDVEFSAEHFGDCLENMDFVIDVLKAVVEAGATT 183 Query: 166 INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQV 225 IN+P+TV P + + +YE +P ISVH H+DLG+A ++ + GA Q+ Sbjct: 184 INLPNTVERYRPKLYVDQVKQVYEALPK--NITISVHCHNDLGMATAATVESFFVGATQL 241 Query: 226 EGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANK 285 E A+NG+GER GN + EV + + V T ++ + I+ T+ LVS +PI Sbjct: 242 EVALNGLGERCGNTNFYEVAIGLHNSG----VDTGLHLERIYETAILVSHWSGVPIYIRA 297 Query: 286 AIVGSGAFAHSSGIHQDGVLKNRE----NYEIMTPESIGLNQIQ-LNLTSRSGRAAVKHR 340 ++G+ A H SGIHQDG K ++ Y + IG NQ L+ TS+SGR AV Sbjct: 298 PLIGTEAIVHRSGIHQDGASKTKDMKKGAYRPIDYSIIGRNQNDTLSFTSQSGRTAVYEI 357 Query: 341 MDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQS 400 + + GYK + L +L++ +G++ E + + ++Q + RL + +++ Sbjct: 358 ITKFGYKMTLQEASKLQPVLKRLSEAEGEL---SAERVLDVFREQFVNVNGRLVFNNIEV 414 Query: 401 GSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDA 460 ++ E ++ GP++A + I VELVKY KD Sbjct: 415 IPDE-NRFIFHFKKDGEALVKSVTAEGPIEAALMLMREI-GMPVELVKYRQLVVPE-KDK 471 Query: 461 L----GQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAA 503 L G IV NG G G+++D ++++ +A+ +N I++ A Sbjct: 472 LWAGRGLSRIVLKANGEEVEGRGVSSDTLKANMRALFGGVNLIYKKA 518 >UniRef50_B3PEP5 2-isopropylmalate synthase n=90 Tax=Bacteria RepID=B3PEP5_CELJU Length = 673 Score = 375 bits (963), Expect = e-102, Method: Composition-based stats. Identities = 124/528 (23%), Positives = 223/528 (42%), Gaps = 38/528 (7%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + I T LRDG QAL +SV+ KL++ L +G +E+GFP +S D+ + + Sbjct: 147 KPPIWMSTDLRDGNQALIDPMSVQTKLRMFKELVAIGFKEIEIGFPSASEIDYNFTRMLI 206 Query: 63 RQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + + + L + I+ +SL+ A +H + +P + + V Sbjct: 207 EENLIPDDVTIEVLVQARYDLIEKTVQSLRGARRAILHMYNPLAPAFRKIVYNTDKEGVK 266 Query: 120 ERAIYMVKRARNYTD-------DVEFSCEDAGRTPIADLARVVEAAINAGAT------TI 166 + A+ + + T ++S E T I + V +A + + Sbjct: 267 KIALQGTQWCKELTAQAPEVDWTFQYSPEVFSSTEIEFVKEVCDAVVEIWNPSPQKKIIL 326 Query: 167 NIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVE 226 N+P TV P +A I ++ + D +ISVH H+D G AV + AV AGA +VE Sbjct: 327 NLPATVEMNTPNTYADQIEWIHRNIHRRDSIVISVHPHNDRGTAVAAAELAVMAGADRVE 386 Query: 227 GAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKA 286 G + G GER GN L + + + + VH ++ +I + +L + +P+ Sbjct: 387 GCLFGNGERTGNVDLVTLALNLYSQG----VHPGLDFSDIDKVRKLHEECTQLPVHPRHP 442 Query: 287 IVGSGAFAHSSGIHQDGVLKNRE----------NYEIMTPESIGLNQIQLN-LTSRSGRA 335 G F SG HQD + K Y + P + + + + ++SG+ Sbjct: 443 YAGELVFTAFSGSHQDAIKKGFAVQKKDTLWEVPYLPIDPADLNRSYDAVVRVNAQSGKG 502 Query: 336 AVKHRM-DEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQ--QEEPEHFR 392 V + E G + K++D G+ A F + P ++ Sbjct: 503 GVSFLLQQEAGLQLPRRLQIEFSSVVQKVSDSTGKEVKASDIARIFNEEYFAVNSPITYQ 562 Query: 393 LDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLT 452 F+ Q ++ + + V+ + +GNGP+DA AI++ + V ++ Y Sbjct: 563 SSKFTEQDDTHQVDIVIHAQHQNKTVEI-SGSGNGPIDAAAHAISQFIDTEVNVIDYHEH 621 Query: 453 AKGHGKD--ALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNN 498 + G G D A+ V+I NG+ +GVG +I+ S+ KA+++ +N Sbjct: 622 SVGEGSDVVAVTYVEIKVK-NGKPVYGVGQDRNIITSAVKALINGVNR 668 >UniRef50_B1L4G2 Pyruvate carboxyltransferase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L4G2_KORCO Length = 495 Score = 375 bits (963), Expect = e-102, Method: Composition-based stats. Identities = 148/504 (29%), Positives = 250/504 (49%), Gaps = 22/504 (4%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPG-------DFES 57 + IFD+TL GE S ++ KL+IA L+ +GVDV+E GFP SS G + Sbjct: 2 IRIFDSTLTLGEMVPGVSFGLEGKLEIASHLDTLGVDVIEAGFPASSEGEKRVVREVVRN 61 Query: 58 VQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 V+ ++R + VCALAR + +D+ A E+ ++ FI S + + +E Sbjct: 62 VKRLSRSGLSPEVCALARAIREDVKAAVET----GVDSVNIFIPASRLLLERAYGMREEE 117 Query: 118 VIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMP 177 ER V A+++ VEF+ EDAGR+ L + A +GA IN+ D VG +P Sbjct: 118 ARERVREAVSLAKSHDLTVEFTAEDAGRSD-DLLWDLCRIAEESGADRINLSDPVGAMLP 176 Query: 178 FEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 + I+ +R+ ISV +DLG+A NSL+A AGA Q+ ++NG+G +AG Sbjct: 177 DDAKKIVLEAKKRIRK----PISVTFSNDLGMATANSLSAAIAGADQIHVSVNGLGPKAG 232 Query: 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 LE+V++ +K + T + + + S+ V +I +PI IVG F + + Sbjct: 233 IAPLEQVVVGLKKLAGL---DTNVKMELLPSVSEAVERISGIPISEISPIVGPLVFTYEA 289 Query: 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 G+H + +YEI++P +G + + + + SGR AVK + EMGY S+ +++ + Sbjct: 290 GVHVSAISNELSSYEIVSPGEVGRVR-RFWVGTHSGRKAVKEVLKEMGYSASDSDVERIL 348 Query: 358 DAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEE 417 +L+ + ++ + ++ E P F++ + +GS TA ++ G Sbjct: 349 ARVKELSQEGIRITEAIFRSVVEEVLG-ERPRLFKVKEWVAVTGSGITPTATIRALIGGR 407 Query: 418 VKAEAANGNGPVDAVYQAINRITEYN-VELVKYSLTAKGHGKDALGQVDIVANYNGRRFH 476 +++G GPVDA+ +AI I L ++ L A G +A+ ++ I Sbjct: 408 EVISSSSGVGPVDAITKAIRSIQGIPSFNLRRFRLIAVSSGSEAIAELKIRVVGPKGEVE 467 Query: 477 GVGLATDIVESSAKAMVHVLNNIW 500 G + DIV++S KA+ +N I Sbjct: 468 AAGTSRDIVDASLKAIEEAVNKII 491 >UniRef50_Q7VH30 2-isopropylmalate synthase n=16 Tax=Bacteria RepID=LEU1_HELHP Length = 558 Score = 373 bits (958), Expect = e-101, Method: Composition-based stats. Identities = 117/537 (21%), Positives = 211/537 (39%), Gaps = 41/537 (7%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +++ I LRDG QAL +S++EK+ L ++G +EVGFP +S ++ ++T Sbjct: 26 IAKAPIWCSVDLRDGNQALITPMSLEEKITFFKLLLKVGFKEIEVGFPAASETEYRFLRT 85 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + + V L + E I ESL+ + +H + +TS R + DE Sbjct: 86 LIEEDLIPDDVSVQVLTQAREHIIKKTFESLEGCKNAIVHVYNSTSYAQREQVFRKSKDE 145 Query: 118 VIERAIYMVKRARNYT------DDVEFSCEDAGRTPIADLARVVEAAINAGATT------ 165 + A + E+S E T + V A I+ T Sbjct: 146 IKHIACEGAICLKESAAATKGNFRFEYSPESFSGTEVDYALEVCNAVIDIFEPTLEKKLI 205 Query: 166 INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQV 225 IN+P TV ++P +A + + + + N + +IS+H H+D G A+ ++ + AGA ++ Sbjct: 206 INLPVTVEMSLPHIYASQVEYMSKHLKNRENVLISLHPHNDRGCAIADAELGLLAGADRI 265 Query: 226 EGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANK 285 EG + G GER GN + + M + V ++ I + ++ M + + Sbjct: 266 EGTLFGNGERTGNVDIITLAMNMHSHG----VDPKLDFSNIPSICDVYEKVTKMQVYERQ 321 Query: 286 AIVGSGAFAHSSGIHQDGVLK--------NRENYE----IMTPESIGL--NQIQLNLTSR 331 G FA SG HQD + K N + + P+ +G + + S+ Sbjct: 322 PYSGKLVFAAFSGSHQDAIAKGMAYHKEHNLSTWSVPYLPIDPKDVGRVYESDVIRINSQ 381 Query: 332 SGRAAVKHRMDEM-GYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEH 390 SG+ + + + G + ++DK + D F Sbjct: 382 SGKGGIAYILHHHYGVNLPPLFREEFSYYVKNISDKAHKELSPDEICEIFQNDFVNLNNT 441 Query: 391 FRLDYFSVQS-GSNDIATAAVKL------ACGEEVKAEAANGNGPVDAVYQAINRITEYN 443 + F S VKL + + GNG +D++ A+ + Sbjct: 442 LCVQDFHFTHIDSKPSQEFNVKLHILYAKENSKTQQEITGKGNGRLDSIANALREHLNLD 501 Query: 444 VELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIW 500 E++ YS + G + + G++ GVG+ DI+ +S +V LN I Sbjct: 502 FEIIDYSEHSLKKGSTSQAVSYVQIESKGKKCFGVGIDNDIITASIYGLVSALNRII 558 >UniRef50_P58967 2-isopropylmalate synthase 1 n=9 Tax=Euryarchaeota RepID=LEU11_METMA Length = 405 Score = 372 bits (956), Expect = e-101, Method: Composition-based stats. Identities = 135/399 (33%), Positives = 214/399 (53%), Gaps = 15/399 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 + I D TLRDGEQ S ++KL +A L+ MG++V+E GFPV S + E V+ I Sbjct: 20 PLDIEICDVTLRDGEQTPGVVFSKEQKLAVASELDSMGIEVIEAGFPVVSADEKEIVKEI 79 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 A Q NSR+C L+R V+ D+D A E + + FIA S MH+ K +L++++ Sbjct: 80 ANQGFNSRICCLSRAVKGDVDAALE----CDVDIVSIFIAMSDMHLKYKYHRSLEDMLGC 135 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAI-NAGATTINIPDTVGYTMPFEF 180 A ++ A ++ V F+ EDA RTP+ L + + +++ DTVG P Sbjct: 136 AKEAIEYATDHGLKVRFAAEDASRTPVERLKQAFKEVENEYKVQYVSLADTVGILNPTTT 195 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 ++S +++ V I +H HDDLG+A N+LAA AGA+Q+ +N IGERAGN S Sbjct: 196 NYLVSEIFKSV----NTAICIHCHDDLGMATANTLAAAEAGAKQLHTTVNAIGERAGNAS 251 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV++A++V+ I + ++ S++VS+ + NKA+VG AF H SGIH Sbjct: 252 LEEVLVALRVQYGIERY----DTTKLNSLSEMVSEYSGITPSVNKAVVGKNAFTHESGIH 307 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 +L+ YE+ PE +G + L + +G+ A+K ++ +G+ L L + Sbjct: 308 VAAILEEPRTYELFLPEMVGGKRN-LVVGKHTGKKALKGIINSIGFCLEREELCALIEKV 366 Query: 361 LKLADKKGQVFDYD-LEALAFIGKQQEEPEHFRLDYFSV 398 ++K + D LE L KQ+++P + FS+ Sbjct: 367 KVCTEEKHKSISRDQLERLITQVKQEQKPSGSEKEKFSI 405 >UniRef50_A6TTX4 Pyruvate carboxyltransferase n=1 Tax=Alkaliphilus metalliredigens QYMF RepID=A6TTX4_ALKMQ Length = 379 Score = 371 bits (954), Expect = e-101, Method: Composition-based stats. Identities = 115/368 (31%), Positives = 177/368 (48%), Gaps = 12/368 (3%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + I DTTLRDGEQ KEK++IA L+ +GVD +E G P+ + + ++ I Sbjct: 2 RDFYIVDTTLRDGEQTPGVVFLKKEKIKIARMLDELGVDYIEAGIPIMGEEEKDVIREII 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 +++ R + D+D + A IH + S +HI KLR VI++ Sbjct: 62 AMNGKAKILTWNRMKKMDVDASL----ACGAKYIHIAVPASDIHIFQKLRKDRKWVIQQV 117 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 +V V EDA R L + +AAI GA + DT+G P Sbjct: 118 QEVVSYGAEKGCIVSVGAEDASRAEEKFLIEIYQAAIKEGAVRLRYADTLGILTPITTYQ 177 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I + + + A + H H+D G+A NSL+A AGA+ ++ ++NG+GERAGN +LE Sbjct: 178 AIKRICDYI----DADLEFHGHNDFGMATANSLSAFQAGAKYIDCSVNGLGERAGNTALE 233 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E++M +K +L + + I S +V + + +K IVG F+H SGIH D Sbjct: 234 EIVMTLKY---LLKSNHPFEIKRILELSNIVQEASRKIVGESKPIVGKSVFSHESGIHVD 290 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G+LKN YE +P IG + ++ L SGR V +R+ EMG K + + + + K Sbjct: 291 GLLKNPTVYESFSPGEIGRKR-KIVLGKHSGRTTVIYRLQEMGIKVTPKEANEIIEMIHK 349 Query: 363 LADKKGQV 370 Sbjct: 350 KYTYDKNP 357 >UniRef50_B2UP78 2-isopropylmalate synthase/homocitrate synthase family protein n=2 Tax=Bacteria RepID=B2UP78_AKKM8 Length = 544 Score = 370 bits (951), Expect = e-101, Method: Composition-based stats. Identities = 140/541 (25%), Positives = 252/541 (46%), Gaps = 41/541 (7%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 MS ++ ++DTTLRDG Q+ +LS +K++IA L+ +G+D +E G+P ++P + E Sbjct: 1 MSTKIFLYDTTLRDGAQSEDVNLSATDKVRIARQLDYLGMDYIEGGWPGANPVETEFFNA 60 Query: 61 IAR-QVKNSRVCALARCVEK----DIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + ++N+++ A + D +L + A F + P H+ L + Sbjct: 61 MRGVGLRNAKLAAFGSTHHPSHTPETDPTLTALISSGARVAAVFGKSCPRHVEVALGISR 120 Query: 116 DEVIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTV 172 + +E + + ++ F E D + V+ A GA + + DT Sbjct: 121 ERNLEIIGNSISFLKKNMEEAFFDAEHFFDGFKRDQEYALAVLRTAWEHGADCLVLCDTN 180 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G TMP E + II + ER+P A++ +H H+D LAV NSLAAV++GA QV+G +NGI Sbjct: 181 GGTMPEEISSIIRTVRERLP---HALLGIHAHNDCELAVANSLAAVNSGAIQVQGTVNGI 237 Query: 233 GERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 GER GN +L VI ++V+ + + + + T+ VS++ N+ + VG+ A Sbjct: 238 GERCGNANLCSVIPNLQVKMKGFSCLSGASLTRLKSTAAFVSEVSNLAPFRRQPFVGNAA 297 Query: 293 FAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKES--E 350 FAH G+H ++K YE + P +G N ++ +T + GR+ + +G++ + Sbjct: 298 FAHKGGVHVSAIMKEAALYEHIDPSLVG-NAQRVLMTEQGGRSNILSLSRTLGFELEKGD 356 Query: 351 YNLDNLYDAFLKLA----DKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQS----GS 402 LD L A K A D +L L + +P L + S Sbjct: 357 PLLDVLSAAVKKNAALGYDYVAAPASAELLFLRHMPDNALKPYFNILRTVVLTSRHEMDP 416 Query: 403 NDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEY------NVELVKYSLTAKG- 455 + + A++KL V+ AA G GPV A+ +A+ R + L+ Y + Sbjct: 417 DMMVEASLKLDVHGNVEHTAAGGFGPVHALDRALRRALTRWYPELEQMHLIDYKVRVLSP 476 Query: 456 -----------HGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLN-NIWRAA 503 +G + +V I ++ + VG++ +I+E+S +A+ + +++ Sbjct: 477 TRTNIPEAEDENGTGSNVRVLIESSDGVATWTTVGVSYNIIEASLEALADAVTYKLYKTE 536 Query: 504 E 504 + Sbjct: 537 Q 537 >UniRef50_Q2JTM1 Homocitrate synthase NifV n=7 Tax=Cyanobacteria RepID=Q2JTM1_SYNJA Length = 395 Score = 370 bits (949), Expect = e-100, Method: Composition-based stats. Identities = 120/382 (31%), Positives = 180/382 (47%), Gaps = 16/382 (4%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+ + I DTTLRDGEQA + + EK+ IA L+ +GV +EVG P + E+++ Sbjct: 1 MNSSITINDTTLRDGEQAAGVAFQIPEKISIAALLDAIGVPEIEVGIPAMGAVETEAIRA 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 + + + R V DI + RIH + S IA K + ++ Sbjct: 61 MLSLGLRAHLLGWNRAVPSDILASIR----CGLKRIHISVPVSDRQIAAKFQGDRPRLLR 116 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 + V+ A V EDA RT + + + + A + G DTVG PF Sbjct: 117 QLRQCVEMALEQGLWVSVGAEDASRTSLEQVIELAQMAQSWGCRRFRYCDTVGVLDPFST 176 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 I L + + +HTHDDLG+A N+LA + AGA+ V +NG+GERAGN Sbjct: 177 YKQIRRLVRAI----DIPVEMHTHDDLGMATANALAGIRAGAQSVNTTVNGLGERAGNAP 232 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV+MA++ I ++ + + SQ V++ P+P KAIVG AFAH SGIH Sbjct: 233 LEEVVMALRCTLGI---DVGVDTRRLRELSQQVARASGAPLPPWKAIVGDNAFAHESGIH 289 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE---SEYNLDNLY 357 GVL++ + YE PE++G + +L L SGR + + E G L+ L Sbjct: 290 AAGVLRDPQTYEPFPPEAVGSQR-RLVLGKHSGRHLLLQILKEHGIPVEQIPPGQLEKLL 348 Query: 358 DAFLKLADK-KGQVFDYDLEAL 378 + + K + +L Sbjct: 349 EQVRQHVTHCKHPIPPAELARY 370 >UniRef50_D2RXB9 Pyruvate carboxyltransferase n=3 Tax=Halobacteriaceae RepID=D2RXB9_9EURY Length = 438 Score = 369 bits (948), Expect = e-100, Method: Composition-based stats. Identities = 150/396 (37%), Positives = 215/396 (54%), Gaps = 18/396 (4%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + +FDTTLRDGEQ+ S S +K QIA L+ MG V+E GFPV+S +FE+V+ IA Sbjct: 56 ESARVFDTTLRDGEQSPGTSFSYDDKRQIASILDEMGTHVIEAGFPVNSDAEFEAVRDIA 115 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 + C LAR V+ DI+ A +S +HTF++TS + I + +T DEV+ERA Sbjct: 116 SSTSTTT-CGLARVVDADIEAALDS----GVEMVHTFVSTSDVQIEDSMHATRDEVVERA 170 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + V+R FS DA RT L ++EA AG INIPDT G P F Sbjct: 171 VESVERVTETGTTCMFSPMDATRTDEQFLLEIIEAVSEAGVDWINIPDTCGVATPTRFRA 230 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 +I + A I VHTHDD GLA N+LA + AGA Q + ++N IGERAGN + E Sbjct: 231 MIEKVCAH----TDARIDVHTHDDFGLATANALAGIEAGADQAQVSVNSIGERAGNAAYE 286 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E +MA++ + T I+ I S +V + M P NK +VG AF+H SGIH Sbjct: 287 EFVMAVE---SLYQTDTGIDTTRITELSNVVEEKSGMATPGNKPVVGDNAFSHESGIHAA 343 Query: 303 GVLKNRENYEI--MTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 GV++N + +E MTPE +G + +L L +G +V+ R+ E+G++ ++ + + Sbjct: 344 GVIENSDTFEPGVMTPEMVGAER-RLILGKHTGTHSVRERLAELGFEPTDDQVRAVTRRV 402 Query: 361 LKLADKKGQVFDYDLEALAFI---GKQQEEPEHFRL 393 +K +V DLE A +Q +E E R+ Sbjct: 403 KDFGAEKRRVTVDDLERFAEEAGIERQSKEEEEVRV 438 >UniRef50_A6LPH9 Homocitrate synthase n=10 Tax=Clostridia RepID=A6LPH9_CLOB8 Length = 389 Score = 369 bits (947), Expect = e-100, Method: Composition-based stats. Identities = 127/390 (32%), Positives = 200/390 (51%), Gaps = 12/390 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 +++V I DTTLRDGEQ + +EK+ IA L +GVD +EVG P + ++++ I Sbjct: 9 NKKVSIVDTTLRDGEQTAGVVFANEEKIVIAEMLSDLGVDQLEVGIPTMGGDEKKAIKEI 68 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 ++ + A R V DI+ + + + I+ S +HI KL+++ + V+E Sbjct: 69 VKRNLKPSIMAWNRAVVSDIEQSID----CGVDAVAISISVSDIHIQHKLKTSREWVLES 124 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 + V+ A+ V + EDA R L + AA AGA DTVG PF+ Sbjct: 125 MVKSVEFAKKNGLYVSVNGEDASRADKDFLVEYINAAKQAGADRFRYCDTVGIMEPFKIR 184 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 I +Y++ I +HTHDD G+A N++A + GA V +NG+GERAGN +L Sbjct: 185 DDIKYIYDK----TGFDIEMHTHDDFGMATANAVAGIKGGASHVGVTVNGLGERAGNAAL 240 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EEVIMA+ + IN Q SQ VS+ +P KAIVG+ FAH SGIH Sbjct: 241 EEVIMALMLVYGYNG--DGINTQMFREVSQYVSRASGRELPIWKAIVGTNMFAHESGIHA 298 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 DG +K+ +NYE P+ +GL + Q+ + SGRA++ ++ E + +E + + Sbjct: 299 DGAIKDPKNYEAFDPDIVGLER-QIVIGKHSGRASIINKFREYNRELTEDEAKGILELVR 357 Query: 362 KLADK-KGQVFDYDLEALAFIGKQQEEPEH 390 + + K +FD ++ L ++ E + Sbjct: 358 ATSVRLKRTLFDKEVVQLYKEYHRRLEERN 387 >UniRef50_O86511 Uncharacterized AIPM/Hcit synthase family transferase SCO5529 n=62 Tax=Bacteria RepID=LY41_STRCO Length = 534 Score = 369 bits (947), Expect = e-100, Method: Composition-based stats. Identities = 137/515 (26%), Positives = 239/515 (46%), Gaps = 33/515 (6%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV- 65 +FDTTLRDG Q +L+V +KL IA L+ GV +E G+P ++P D E +++ Sbjct: 13 VFDTTLRDGAQREGINLTVADKLAIARHLDDFGVGFIEGGWPGANPRDTEFFARARQEID 72 Query: 66 -KNSRVCALARCVEKDIDVA----AESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 K++++ A + A ++L + A I + H+ LR+TLDE + Sbjct: 73 FKHAQLVAFGSTRRAGANAAEDHQVKALLDSGAQVITLVAKSHDRHVELALRTTLDENLA 132 Query: 121 RAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGYTMP 177 V + V CE D R VV A AGA + + DT G +P Sbjct: 133 MVADTVSHLKAQGRRVFVDCEHFFDGYRANPEYAKSVVRTASEAGADVVVLCDTNGGMLP 192 Query: 178 FEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 + +++ + A + +H DD G AV N+LAAV AGA V+ NG GER G Sbjct: 193 AQIQAVVATVLAD----TGARLGIHAQDDTGCAVANTLAAVDAGATHVQCTANGYGERVG 248 Query: 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 N +L V+ A++++ V +E+ R S ++++ N+ ++ VG AFAH + Sbjct: 249 NANLFPVVAALELKYG-KQVLPEGRLREMTRISHAIAEVVNLTPSTHQPYVGVSAFAHKA 307 Query: 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 G+H + + + Y+ + PE +G N +++ ++ +GRA+++ + E+G + + Sbjct: 308 GLHASAIKVDPDLYQHIDPELVG-NTMRMLVSDMAGRASIELKGKELGIDLGGDR-ELVG 365 Query: 358 DAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDI---------ATA 408 ++ +++ + Y+ +F + E E L YF V+S A Sbjct: 366 RVVERVKERELAGYTYEAADASFELLLRAEAEGRPLKYFEVESWRAITEDRPDGSHANEA 425 Query: 409 AVKLACGEEVKAEAANGNGPVDAVYQ----AINRITEY--NVELVKYSLTAKG--HGKDA 460 VKL E A GNGPV+A+ + A+ +I ++LV Y + HG + Sbjct: 426 TVKLWAKGERIVATAEGNGPVNALDRSLRVALEKIYPELAKLDLVDYKVRILEGVHGTQS 485 Query: 461 LGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHV 495 +V I + + VG+A +++ +S +A+ Sbjct: 486 TTRVLISTSDGTGEWATVGVAENVIAASWQALEDA 520 >UniRef50_C9RN88 2-isopropylmalate synthase/homocitrate synthase family protein n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RN88_FIBSS Length = 535 Score = 368 bits (944), Expect = e-100, Method: Composition-based stats. Identities = 139/518 (26%), Positives = 249/518 (48%), Gaps = 32/518 (6%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFP-VSSPGDFESVQTIA 62 +V+++DTTLRDG Q + SLS+ +K+QIA L+ G D +E G+P S+P D E + I Sbjct: 2 KVLLYDTTLRDGNQDRKISLSLADKVQIARILDHFGFDYIEGGWPNPSNPTDEEFFKLIK 61 Query: 63 R-QVKNSRVCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 ++K++++ A I D ++L +EA F + +H+ +R+TL+E Sbjct: 62 DVKLKHAKIAAFGSTRRPGILPENDPLLQALIKSEAPVKTIFGKSWDLHVTDVIRTTLEE 121 Query: 118 VIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGY 174 ++ V + ++++V + E D + ++AA A I + DT G Sbjct: 122 NLDMIESSVAYLKEHSEEVIYDAEHFFDGYKANPEYALETLKAAELGHADCIVLCDTNGG 181 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 TMP+E I+ + R+ + +H H+D GLAV NS+ AV AG V+G +NG GE Sbjct: 182 TMPWEIEEIVKKVQTRI----STPLGIHVHNDSGLAVANSIYAVKAGCVMVQGVVNGYGE 237 Query: 235 RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFA 294 R GN +L + +K + D + A + + S + QI N+P + VG AFA Sbjct: 238 RCGNANLTTIAADLKFKMD-RDFAAAKKLSHLRQLSGNIDQIVNLPSDVHAPYVGDAAFA 296 Query: 295 HSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMD--EMGYKESEYN 352 H G H DGV+K ++E + P S+G +++ + ++G + V ++ + G + + Sbjct: 297 HKGGAHIDGVMKVSRSFEHIDPHSVGNDRV-FVTSDQAGGSLVVEKLKAIKPGIDKKDPV 355 Query: 353 LDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQE--EPEHFRLDYFSVQSGSND----IA 406 + +L K + G FD + + + E F++ + V ++ Sbjct: 356 VASLLKEI-KERENAGWHFDSAEASFKLLVYRHLGMVKEPFKVLNYRVIEDKTPQGVSVS 414 Query: 407 TAAVKLACGEEVKAEAANGNGPVDAVYQAINRIT------EYNVELVKYSLTAKGH--GK 458 A VKL G+++ + + G+GPV+A+ A+ + +V L + + G Sbjct: 415 QATVKLQVGDKISHQVSEGDGPVNALDAALRKALLPFFPCMGSVRLDDFKVRVLGSNVAS 474 Query: 459 DALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVL 496 DA +V ++ VG++++I+E+ A V L Sbjct: 475 DATVRVWTTFGDEHGYWNMVGVSSNIIEACWTAFVDGL 512 >UniRef50_A1KBD3 2-isopropylmalate synthase n=14 Tax=Bacteria RepID=LEU1_AZOSB Length = 572 Score = 367 bits (943), Expect = e-100, Method: Composition-based stats. Identities = 131/540 (24%), Positives = 220/540 (40%), Gaps = 51/540 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +++ + T LRDG QAL ++ + K+++ L +G+ +EV FP +S DF+ V+ Sbjct: 35 ITRPPVWMSTDLRDGNQALFEPMNSERKMRMFKMLVEIGLKEIEVAFPAASQTDFDFVRE 94 Query: 61 IARQV---KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + + L + I+ ES++ A+ +H + A +P + Sbjct: 95 LIEGGHIPDDVTIEVLTQARPHLIERTFESVRGAKRAIVHVYNAVAPNFRRIVFDTDRAG 154 Query: 118 VIERAIYMVKR-----ARNYTDDVEF--SCEDAGRTPIADLARVVEAAINAGATT----- 165 V + A+ + AR D F S E T + V A I T Sbjct: 155 VKQIAVDSARYFVEMAARQPGTDFTFQYSPEVFSGTELDFAVEVANAVIEVWQPTPQQKC 214 Query: 166 -INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 IN+P TV + P +A I ++ + D ++SVH H+D G AV + AV AGA + Sbjct: 215 IINLPATVEMSTPNVYADQIEWMHRHLARRDSVLLSVHPHNDRGTAVAAAELAVMAGADR 274 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 VEG + G GER GN L + + + + VH ++ I ++ V +PI Sbjct: 275 VEGCLFGNGERTGNVDLVTLALNLYSQG----VHPGLDFSRINEVARTVEHCTQLPIHPR 330 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNRE----------NYEIMTPESIGLN-QIQLNLTSRSG 333 VG F SG HQD + K Y + P +G + + + + S+SG Sbjct: 331 HPYVGDLVFTAFSGSHQDAIKKGFAVQQPDAVWEVPYLPVDPADLGRSYESIIRVNSQSG 390 Query: 334 RAAVKHRMD-EMGYKESEYNLDNLYDAFLKLADKK------GQVFDYDLEALAFIGKQQE 386 + + + ++ E G A ++ D++ G ++ E + Sbjct: 391 KGGIAYLLEAEYGLVMPRRLQVEFSAAIQRITDERGTELSAGDIWRAFEEEYLAVAAPYA 450 Query: 387 EPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVEL 446 EH ++ Q S + A V+ + GNGP+DA A+ + L Sbjct: 451 YVEHHLAEHGGQQGISLTVEEAGVR-------RVLRGVGNGPIDAALHAL----DAGAVL 499 Query: 447 VKYSLTAKGHGKDALGQVDIVANY--NGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAE 504 + Y A G G DA I G GVG+ +IV +S A+V L+ + + E Sbjct: 500 LGYEERAIGQGGDARAVAYIELADGEGGGSTFGVGIHANIVTASVLAIVSALDRLAQRRE 559 >UniRef50_B3DXX9 Homocitrate/citramalate synthase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DXX9_METI4 Length = 380 Score = 367 bits (942), Expect = e-100, Method: Composition-based stats. Identities = 114/375 (30%), Positives = 176/375 (46%), Gaps = 12/375 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+ ++++ DTTLRDGEQA S ++K+QI L + G+ +E G P S + E+ Sbjct: 1 MNGKILLADTTLRDGEQAPGVFFSPRQKVQIVKLLAQCGIKEIEAGTPSSCKTEMEAFHK 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I R+ A R +D+ ++K + ++ I S + I+TKLR+ +V+E Sbjct: 61 ILSLGLKVRIVAWGRMTNEDLQ----AVKSSRVSTVNLSIPLSDIQISTKLRTNRKQVLE 116 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 + V +AR +V ED+ R L +E A GA DTVG P Sbjct: 117 KIKEYVGKAREMGLEVALGGEDSSRAEENFLVEAIEVAKQEGAFRFRYADTVGILDPLCT 176 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 +S L + + H HDD G+A NS+AA AG + + G+GERAGN + Sbjct: 177 YQTLSRLKKW----TSFPLEFHGHDDFGMATANSIAAWRAGVASISATLCGLGERAGNGA 232 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEE+ + +R++ V I+ + ++ L S++ IP K+I+G F H SGIH Sbjct: 233 LEEIAFFLALREN---VDVGIDLKGLFSLCLLTSRLSKRKIPPWKSIIGEEIFLHESGIH 289 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 DG+LKN NYE P IG + L SGR +V +++G SE + Sbjct: 290 VDGILKNPRNYEPFNPSIIGRKH-RFTLGKHSGRKSVLWTYEKLGITLSEQKATEILHKI 348 Query: 361 LKLADKKGQVFDYDL 375 K + + Sbjct: 349 KNFTATKKRPPSKEE 363 >UniRef50_B2AHM5 2-isopropylmalate synthase n=69 Tax=cellular organisms RepID=LEU1_CUPTR Length = 569 Score = 366 bits (941), Expect = e-100, Method: Composition-based stats. Identities = 127/534 (23%), Positives = 220/534 (41%), Gaps = 41/534 (7%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +++ T LRDG QAL ++ KL++ L ++G+ +EV FP +S DF+ V+ Sbjct: 27 ITRAPRWMSTDLRDGNQALIEPMNPARKLRLFEQLVKIGLKEIEVAFPAASQTDFDFVRM 86 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + + + L + E I ES++ A +H + +P ++ DE Sbjct: 87 LIEERRIPDDVTIVVLTQSREDLIRRTVESVRGAARATVHLYNPIAPAWRRIVFNASRDE 146 Query: 118 VIERAIYMVKRARNYTD-------DVEFSCEDAGRTPIAD---LARVVEAAINAGATT-- 165 + A+ + + TD E+S E + ++ V AA AG Sbjct: 147 IKAVAVSGTRLIKALTDAMPETAWTYEYSPETFSLAELDFSLEVSDAVSAAWQAGPGRPM 206 Query: 166 -INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 +N+P TV + P FA I ++ R+ ++SVH H+D G AV + A+ AGA + Sbjct: 207 ILNLPTTVECSTPNVFADQIEWMHRRLARRAHIVLSVHPHNDRGTAVAAAELALMAGADR 266 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 VEG + G GER GN L + + + + V ++ +I Q V +P+ Sbjct: 267 VEGCLFGNGERTGNVDLVTLALNLYTQG----VAPELDFSDIDAVRQCVEHCNQLPVHPR 322 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNRE----------NYEIMTPESIGLNQ-IQLNLTSRSG 333 VG F SG HQD + K Y + P +G + + + S+SG Sbjct: 323 HPYVGDLVFTAFSGSHQDAIRKGFAQQQPDAIWEVPYLPIDPADLGRSYDAVIRVNSQSG 382 Query: 334 RAAVKHRMDE-MGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFR 392 + + + +++ G A + D G + + L + +++ Sbjct: 383 KGGMAYLLEQVHGLYLPRRLQIEFSRAVQAMTDDTG--LEASADDLYGLFRREYLARETP 440 Query: 393 LDYFSVQSGSNDI-ATA-AVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYS 450 L Y S Q S+ ATA V++ + GNGP+DA A+ + V ++ Y Sbjct: 441 LRYVSHQLASDATGATAITVQMERDGQPCTVRGTGNGPIDAFIDAL----DLPVRVMDYH 496 Query: 451 LTAKGHGKDALGQVDIVANYNGR-RFHGVGLATDIVESSAKAMVHVLNNIWRAA 503 A G DA + G G+ +V +S +A+V +N +A Sbjct: 497 EHAMTAGADARAACYVEVRVGDSPTGFGAGIDASLVTASLRAVVSGVNRHLQAG 550 >UniRef50_A0LSS5 2-isopropylmalate synthase n=12 Tax=Bacteria RepID=A0LSS5_ACIC1 Length = 554 Score = 365 bits (938), Expect = 2e-99, Method: Composition-based stats. Identities = 138/520 (26%), Positives = 241/520 (46%), Gaps = 33/520 (6%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 ++DTTLRDG Q +L+V +KL IA L+ +GV +E G+P + P D E + Sbjct: 14 PAGFQVYDTTLRDGAQGEGMALTVADKLAIARHLDDLGVGFIEGGWPGALPKDTEFFRRA 73 Query: 62 ARQV--KNSRVCALARCVEKDIDVAAE----SLKVAEAFRIHTFIATSPMHIATKLRSTL 115 ++ +N+ + A + + V A+ +L AE + + H++ LR++L Sbjct: 74 RTELTLRNAVLVAFGATRKPESRVEADPQVLALLEAETPAVCLVAKSHVRHVSEALRTSL 133 Query: 116 DEVIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTV 172 DE + V R V E D V A +GA + + DT Sbjct: 134 DENLAMIRDTVAFFRREGRRVFLDAEHFFDGYAADPQYAVECVRVAAESGAEVVVLCDTN 193 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G +P A ++ + ER + +H HDD G AV N+LAAV AG QV+G +NG Sbjct: 194 GGMLPPRIADVVHEVAER----TGVPLGIHCHDDTGCAVANTLAAVDAGVVQVQGVVNGY 249 Query: 233 GERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 GER GN +L V+ ++++ V E+ R S ++++ N P AN+ VG A Sbjct: 250 GERCGNANLITVVANLELKMG-RRVLPPGRLAELGRVSHAIAEVANQPPRANQPYVGLSA 308 Query: 293 FAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKES--E 350 FAH +G+H + + + Y+ + P +G N +++ ++ +GRA+V+ + ++G+ S Sbjct: 309 FAHKAGLHASAIKVSPDLYQHIDPALVG-NDMRMLVSEMAGRASVELKSRQLGFDLSGQR 367 Query: 351 YNLDNLYDAFLKLADKKGQVF---DYDLEALAFIGKQQEEPEHFRLDYFSV----QSGSN 403 + + + L + +G +F D E L F L+ + V ++ Sbjct: 368 DAVSRIVERVKNL-EARGFMFEAADASFELLLREELDGVPTRFFDLESWRVIVERRADGE 426 Query: 404 DIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEY------NVELVKYSLTAK--G 455 ++ A VK+ E A GNGPV+A+ +A+ + E +ELV Y + Sbjct: 427 VVSEATVKVVVKGERIVATAEGNGPVNALDRALRQALERLYPQLAELELVDYKVRILDGS 486 Query: 456 HGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHV 495 HG A+ +V I + + +G+ +++ +S +A+ Sbjct: 487 HGTGAVTRVLIETSDGETEWTTIGVDGNVISASWQALDDA 526 >UniRef50_C4XS62 Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio magneticus RS-1 RepID=C4XS62_DESMR Length = 394 Score = 365 bits (937), Expect = 2e-99, Method: Composition-based stats. Identities = 142/364 (39%), Positives = 195/364 (53%), Gaps = 4/364 (1%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 +II DTTLRDG Q S+ +K+ IA ALE GVDV+E GFP G+ E+V+ +A Sbjct: 10 LIISDTTLRDGAQMPGVHFSINDKVAIAQALEAAGVDVIEAGFPAGGAGEIEAVRQVAAA 69 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFR--IHTFIATSPMHIATKLRSTLDEVIERA 122 + AL R V+ D+D A ++L A A R + F+ATSP+H KL T + + Sbjct: 70 TARPLIMALCRAVDADVDAAWQALGDAPAERRGVGVFLATSPLHRRHKLGKTKAQCLAMI 129 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 V AR V F CED RT A L AA++AGAT I PDTVG P Sbjct: 130 ASSVAYARQRFARVTFGCEDGSRTEPAFLREAYTAAMDAGATAIGFPDTVGVLTPETARR 189 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I+ L R+ + H H+DLGLA N+LAA+ AGA V + GIGERAGN +LE Sbjct: 190 RIAMLV-RLAQPRGVKVRAHFHNDLGLATANTLAAIAAGADIVHLTVGGIGERAGNAALE 248 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E +MA+ + ++ + +LV+Q +P NKA+ G+ FA ++G+HQD Sbjct: 249 ETVMALTLHPGQYRRAINVDTTRLTALCRLVAQRAGFTLPPNKAVTGANVFATAAGVHQD 308 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G+LK+ + Y PE +G I+L L+ SG+AA+ R E+G S L +K Sbjct: 309 GLLKHPDTYLPFRPELVGAEGIRLPLSPLSGKAALALRYTELGIALSADELSRA-SRLVK 367 Query: 363 LADK 366 ADK Sbjct: 368 DADK 371 >UniRef50_Q8KTR5 Alpha-isopropylmalate synthase n=14 Tax=Candidatus Tremblaya princeps RepID=Q8KTR5_TREPR Length = 390 Score = 364 bits (935), Expect = 5e-99, Method: Composition-based stats. Identities = 154/374 (41%), Positives = 220/374 (58%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + I DTTLRDGEQA + K ++A LE GVDV+E GF SS DFE+++ I+ Sbjct: 9 IAILDTTLRDGEQAPCIVMGPDAKAEMARRLEIAGVDVVEAGFAASSSSDFEAIRRISCC 68 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 V+ VC+LAR V D+ AA++L+ A RIH FI +S +HI KLR +V++RA Sbjct: 69 VRGCVVCSLARAVGHDVRKAAKALEFARHPRIHVFIGSSSLHIEEKLRMHPLDVVDRAAA 128 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 MV+ AR Y DDVEFS ED+ R + L + +AA+ AGAT +N+ DTVG+ +P + + + Sbjct: 129 MVRLARAYCDDVEFSPEDSSRADPSFLCSLAKAAVEAGATIVNVTDTVGHGIPEQLSDVA 188 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 L VP D+ +SVH H+D+GLA+ N++AA+ A Q E + GIGERAGN +LEEV Sbjct: 189 GMLCRSVPISDRVTLSVHCHNDVGLALANTMAAIACCAGQAECTVTGIGERAGNAALEEV 248 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 ++A + + ++ + + +QL S I +PA K +VG AFAH+SGIHQDGV Sbjct: 249 VVAAGLEYSGAGMDVRVDARHMRSIAQLASAIARRRLPATKPVVGCHAFAHASGIHQDGV 308 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 +KNR YE + E +G + L SG A+++R++ G + L LA Sbjct: 309 IKNRRTYEALRAEDVGGRGGSIVLGKLSGTHALRNRLEGGGVTIGAMGVPRLATMMKGLA 368 Query: 365 DKKGQVFDYDLEAL 378 V+D L AL Sbjct: 369 SHLPVVYDSALAAL 382 >UniRef50_Q44290 Homocitrate synthase 1 n=45 Tax=Bacteria RepID=NIFV1_ANASP Length = 377 Score = 363 bits (931), Expect = 1e-98, Method: Composition-based stats. Identities = 123/372 (33%), Positives = 180/372 (48%), Gaps = 12/372 (3%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 +V+I DTTLRDGEQA +++EK+ IA L+ +GV +EVG P + ++ I+ Sbjct: 3 KVLINDTTLRDGEQAAGVVFTLEEKVAIAKFLDTIGVPELEVGIPAMGEEEMRAICAISN 62 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 + + A R V DI + R+H I S + IA K ++R Sbjct: 63 LGLKANLLAWNRAVISDIKASV----ACGMERVHIAIPVSGIQIAAKFHGQWRVSLQRLK 118 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 + A + V ED+ R L V A GA+ DTVG PF G Sbjct: 119 DCISFAVDQGLWVAVGGEDSSRADENFLLDVALYAQEWGASRFRFCDTVGVLDPFTTYGK 178 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 + L + + VHTH+D G+A N+LA + AGA V + G+GERAGN +LEE Sbjct: 179 VKLLVSALT----IPVEVHTHNDFGMATANALAGIKAGASSVNTTVIGLGERAGNAALEE 234 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 V+MAI K I V I+ + SQLV+ +P KAIVG FAH SGIH G Sbjct: 235 VVMAI---KRIYGVDMGIDTPRLLELSQLVAAASGANVPPWKAIVGENTFAHESGIHAHG 291 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 VL+N + YE PE +G + +L + SGR +V + +++ G + ++ DA + Sbjct: 292 VLQNPDTYEPFAPEEVGWER-RLVVGKHSGRHSVSNLLEQHGIFLNPEETQSVLDAVRQQ 350 Query: 364 ADKKGQVFDYDL 375 + KK + + Sbjct: 351 SIKKKRSLTTEE 362 >UniRef50_D2L197 Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio sp. FW1012B RepID=D2L197_9DELT Length = 400 Score = 362 bits (929), Expect = 2e-98, Method: Composition-based stats. Identities = 141/371 (38%), Positives = 205/371 (55%), Gaps = 4/371 (1%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 +I+ DTTLRDG Q SV +K+ IA AL GV V+E GFP S + E+V+ I + Sbjct: 17 LILSDTTLRDGAQMPGVRFSVDDKVAIAKALADAGVGVIEAGFPAGSEREIEAVRRICAE 76 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVA--EAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 V R+ L R V DID A E+L A E + F+ATSP+H KL + + ++ Sbjct: 77 VPGPRIMVLCRAVAGDIDAAWEALADAAPEGRGVGIFLATSPLHRRHKLGKSKAQCLDMI 136 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 V AR V FSCED RT A L + A++AGAT I PDT+G P Sbjct: 137 GRAVAYARKRFLKVTFSCEDGSRTEPAFLRQAYGVAMDAGATGIGFPDTLGVLTPEAVRR 196 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + + + + + VH H+DLGLA N+LAAV AGA V + GIGERAGN +LE Sbjct: 197 RVR-MLAALAHPRGVRLRVHFHNDLGLATANTLAAVAAGADIVHLTVGGIGERAGNAALE 255 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E +MA+ + + ++ ++ +LVS++ +P+ ANKA+VG+ FA S+G+HQD Sbjct: 256 ETVMALILNQKQYRRSIGVDPAKLTGLCRLVSRLSGVPLAANKAVVGANIFATSAGVHQD 315 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G+LK+ + Y PE++G + I+L L+ SG+AA+ R+ E+G + S L +K Sbjct: 316 GLLKHPDTYLPFRPEAVGADGIRLPLSPLSGKAALALRLAELGIELSPDELGR-TSRIMK 374 Query: 363 LADKKGQVFDY 373 A K+ + Sbjct: 375 NAGKEAWADEE 385 >UniRef50_Q2FKU8 2-isopropylmalate synthase n=3 Tax=Methanomicrobiales RepID=Q2FKU8_METHJ Length = 393 Score = 362 bits (929), Expect = 2e-98, Method: Composition-based stats. Identities = 126/384 (32%), Positives = 200/384 (52%), Gaps = 13/384 (3%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 + I D TLRDGEQ S + EK IA L+ +G++V+E GFP+ S + E V+ I+R Sbjct: 5 HIEICDVTLRDGEQTPGVSFTADEKKDIASRLDAIGIEVIEAGFPIVSAHEKEMVRNISR 64 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 ++++C L+R +D+D A + AE I FIA S +H+ K + D V+ A+ Sbjct: 65 LGLSAKICGLSRACREDVDAALD----AEVDMIGLFIAPSDLHLKYKHKKPRDVVVANAL 120 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 + A ++ V F EDA RT L + A + AT + DT G P E A + Sbjct: 121 EQLDYAVDHGLIVRFGAEDASRTDPDILVDIYRQAADHKATYVTYADTTGCLTPLEVATV 180 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 + L + P I++H H+DLG A N+L A GA Q+ +NG+GERAGN LEE Sbjct: 181 MKDLVPKTP----IPIAMHAHNDLGCATANTLIAAELGAYQLHTTVNGLGERAGNARLEE 236 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 V++++ ++ I T + EI S+ V Q + +PA K +VG+ AFAH SGIH Sbjct: 237 VLVSLVLKGGI----TRYDLTEIPALSERVQQYTGIFMPATKPVVGANAFAHESGIHIAA 292 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 +L+N E YE + PE +GL + + L +G+ A+ H + GY ++ + + + Sbjct: 293 ILENPETYEFIPPELLGLER-RFILGKHTGKRALVHILTSFGYHITDEQVMQVLELIKDK 351 Query: 364 ADKKGQVFDYDLEALAFIGKQQEE 387 ++ K + L + +++ Sbjct: 352 SEDKCSINQRVLAEIISQVTGEDK 375 >UniRef50_C3MPM7 2-isopropylmalate synthase n=19 Tax=Thermoprotei RepID=LEU1_SULIL Length = 461 Score = 361 bits (926), Expect = 5e-98, Method: Composition-based stats. Identities = 132/416 (31%), Positives = 208/416 (50%), Gaps = 22/416 (5%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 +V I D+TLR+GEQ +V ++++IA AL +GV ++E G P SP +E ++ I + Sbjct: 3 KVGILDSTLREGEQTPGVIFTVDQRVEIAKALSDLGVSMIEAGHPAVSPDIYEGIKRIVK 62 Query: 64 QVK----NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 K S + +R V++DI++AAE E RI F S +H+ K ++T +E + Sbjct: 63 LKKEGIITSEIVGHSRAVKRDIEIAAE----LEVNRIAIFYGVSDLHLKAKHKATREEAL 118 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE 179 + A+N+ V F+ ED RT L V + A +AGA ++I DTVG P + Sbjct: 119 RTIAETISYAKNHGVKVRFTAEDGSRTDFDFLVTVSKTARDAGADRVSIADTVGILYPSK 178 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 + S L VPN++ +H H+DLGLAV N+LAA+ GA + +NG+GER G Sbjct: 179 TKELFSALTREVPNLE---FDIHAHNDLGLAVANALAAIEGGATIIHATVNGLGERVGIV 235 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 L+++ AIK I + ++ S LV + +P+P N I G AF H +G+ Sbjct: 236 PLQQIAAAIKYHFGIE----VVKLDKLQYVSSLVEKYSGIPMPPNYPITGDYAFLHKAGV 291 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 H GVL + YE M PE+ G + + +G+ A++ + +++G K S+ +D + Sbjct: 292 HVAGVLNDPRTYEFMPPETFGRTR-DYTIDKYTGKHALRDKYEKLGVKISDAEMDQILAK 350 Query: 360 FLKLADKKGQVFDYDLEALAFIGKQQ----EEPEHFRLDYFSVQSGSNDIATAAVK 411 K D DL LA + PE SV+ SN T+ + Sbjct: 351 I-KSNTTIRFYRDVDLLELAEEVTGRVLKPRPPEQIEAL-ISVKCDSNVYTTSVTR 404 >UniRef50_A4QAP0 2-isopropylmalate synthase n=225 Tax=cellular organisms RepID=LEU1_CORGB Length = 616 Score = 360 bits (925), Expect = 6e-98, Method: Composition-based stats. Identities = 135/548 (24%), Positives = 233/548 (42%), Gaps = 59/548 (10%) Query: 10 TTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ---VK 66 LRDG QAL +S + K ++ L +MG +EVGFP +S DF+ V+ I + Sbjct: 72 VDLRDGNQALIDPMSPERKRRMFELLVQMGFKEIEVGFPSASQTDFDFVREIIEKDMIPD 131 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 + + L + E I E+ + A+ +H + +TS + R D+V + A Sbjct: 132 DVTIQVLVQAREHLIRRTFEACEGAKNVIVHFYNSTSILQRNVVFRMDKDQVKKLATDAA 191 Query: 127 KRARNYTDDV-------EFSCEDAGRTPIADLARVVEAAINAGATT------INIPDTVG 173 + + D ++S E T + VV+A + T IN+P TV Sbjct: 192 ELIKTIAQDYPDTNWRWQYSPESFTGTEVEYAKEVVDAVVEVMDPTPENPMIINLPSTVE 251 Query: 174 YTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIG 233 P +A I ++ V D I+S+H H+D G VG + AGA ++EG + G G Sbjct: 252 MITPNVYADSIEWMHRNVNRRDSIILSLHPHNDRGTGVGAAELGYMAGADRIEGCLFGNG 311 Query: 234 ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAF 293 ER GN L + + + + V ++ +I + V + +P G F Sbjct: 312 ERTGNVCLVTLALNMLTQG----VDPQLDFTDIRQIRSTVEYCNQLRVPERHPYAGDLVF 367 Query: 294 AHSSGIHQDGVLKNREN---------------------------YEIMTPESIGLN-QIQ 325 SG HQD V K + Y + P+ +G + + Sbjct: 368 TAFSGSHQDAVNKGLDAMAAKVKPGANSTDVSWEELRDTEWEVPYLPIDPKDVGRDYEAV 427 Query: 326 LNLTSRSGRAAVKHRMD-EMGYKESEYNLDNLYDAFLKLADKKGQVFD----YDLEALAF 380 + + S+SG+ V + M + G + + D +G + +D+ A + Sbjct: 428 IRVNSQSGKGGVAYIMKTDHGLQIPRSMQVEFSAVVQNVTDAEGGEVNSKAMWDIFATEY 487 Query: 381 IGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRIT 440 + ++ E L + Q+ + D + A + G++V + +GNGP+ A A+ ++ Sbjct: 488 L-ERTAPVEQIALRVENAQTENEDASITAELIHNGKDVTVD-GHGNGPLAAYANALEKL- 544 Query: 441 EYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIW 500 +VE+ +Y+ A+ G DA ++A NGR+ GVG+A I +S KA+ +N Sbjct: 545 GIDVEIQEYNQHARTSGDDAEAAAYVLAEVNGRKVWGVGIAGSITYASLKAVTSAVN--- 601 Query: 501 RAAEVEKE 508 RA +V E Sbjct: 602 RALDVNHE 609 >UniRef50_Q0EZI5 2-isopropylmalate synthase n=1 Tax=Mariprofundus ferrooxydans PV-1 RepID=Q0EZI5_9PROT Length = 543 Score = 360 bits (925), Expect = 7e-98, Method: Composition-based stats. Identities = 129/531 (24%), Positives = 246/531 (46%), Gaps = 30/531 (5%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ ++DTTLRDG Q+ S ++K +IA L G+D +E G+P +SP D + + Sbjct: 8 RRIQLYDTTLRDGAQSAGIHFSAEDKKRIARRLASFGMDWIEGGWPGASPTDDCFFELMR 67 Query: 63 RQV-KNSRVCALARCVEKD----IDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + +SR+ A D L A + F + +H+ T L L Sbjct: 68 DRAWSHSRLVAFGSTARPGHPASEDPGLARLVACGADAVCIFGKSWDLHVTTGLGIDLQT 127 Query: 118 VIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGY 174 ++ V + + D V F E D +V+ AA +AGA ++ + DT G Sbjct: 128 NLDLVRESVAWLKLHVDTVLFDAEHFFDGYAANRDYAMQVLAAAADAGADSLVLCDTNGG 187 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 ++P + + + R P++ I +H H+D +AV N+++AV AGA V+G +NG+GE Sbjct: 188 SLPEQIGACVRQVVARYPDL---TIGIHAHNDSEMAVANAVSAVSAGASHVQGTINGLGE 244 Query: 235 RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFA 294 R GN +L VI +K++ + + + +++ R S V+++ N ++ VG AFA Sbjct: 245 RCGNTNLISVIPVLKLKMGVNCGVSTESLRKLRRLSTFVNEMANQLPWQHQPFVGQNAFA 304 Query: 295 HSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK--ESEYN 352 H GIH V K YE + P S+G N ++ +++++GR+ + ++ ++ + Sbjct: 305 HKGGIHVSAVRKASHLYEHIDPASVG-NAQRVLVSNQAGRSNILAKLQQLEPDAIVDDAA 363 Query: 353 LDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQ--EEPEHFRLDYFSVQSGSNDI----- 405 + K + G F+ + + ++ + HF L F V Sbjct: 364 VVRAVQRI-KEMEATGYAFEGADASFQLLLRRATGQFRRHFELVSFRVYDEKRGHDEAPE 422 Query: 406 ATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITE------YNVELVKYSLTAKG--HG 457 + A V++ + AA G+GPV+A+ +A+ ++ L + + Sbjct: 423 SEATVQVRVNGRLLHTAALGSGPVNAMDKALRAALTGAYPGLEDMRLTDFKVRVLSTKDA 482 Query: 458 KDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKE 508 +A +V I ++ R+++ VG++TD++E++ +A+ + +V E Sbjct: 483 TEAAVRVLIESSDGVRKWNTVGVSTDVLEATYRALNDAIEYKLVMDQVASE 533 >UniRef50_D1N7Y9 Pyruvate carboxyltransferase n=2 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N7Y9_9BACT Length = 567 Score = 358 bits (918), Expect = 4e-97, Method: Composition-based stats. Identities = 119/542 (21%), Positives = 218/542 (40%), Gaps = 47/542 (8%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 ++Q + LRDG QAL + + KL+ L +G +EV FP +S DF V+ Sbjct: 25 LTQPPVWASVDLRDGNQALPEPMGPEHKLEYFNMLVGIGFKEIEVAFPSASADDFNFVRM 84 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + + R+ L + ID ESL+ + H ++ TS +H +E Sbjct: 85 LIERNLIPDDVRISVLTQARRHLIDRTIESLRGVKHAIAHCYVPTSDLHGRFVFNHNREE 144 Query: 118 VIERAIYMVKRARNYTDD--------VEFSCEDAGRTPIADLARVVEAAINAGAT----- 164 V + A+ + + + EFS E+ + + + V A Sbjct: 145 VKQMAVDGTRMVKEAIEREGLWGKVAYEFSPEEFTDSDLDFVVEVCCAVKEVWGPSTPDM 204 Query: 165 -TINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGAR 223 +N+P TV P ++A +I + P +++ +S+H H+D G AV + A+ AGA Sbjct: 205 LILNLPATVERRPPNQYADMIELFCRKFPYLNEVGLSLHAHNDQGCAVAATELALLAGAT 264 Query: 224 QVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 +VEG + G GER GN + + + ++ R V T +N + ++V + + + Sbjct: 265 RVEGTVFGHGERTGNLDVSVLALNMESRG----VRTGLNFSNMPEIVRIVERNSGIEVHP 320 Query: 284 NKAIVGSGAFAHSSGIHQDGVLKNRE---------------NYEIMTPESIGLNQIQ-LN 327 G F SG HQD + K E Y + P +G + + Sbjct: 321 RHPYAGDLVFTAFSGSHQDAIRKGFEHRAEISEFFRQGWKIPYLHLDPADLGRQYEKLIR 380 Query: 328 LTSRSGRAAVKHRMD-EMGYKESEYNLDNLYDAFLKLAD-KKGQVFDYDLEALAFIGKQQ 385 + S+SG+ V + ++ E G + + K+ D + G++ DL+ + + Sbjct: 381 INSQSGKGGVVYVLEKEFGVYPPKTMHPEIGAVVQKVVDAEGGEINSADLKRIFYDNFVN 440 Query: 386 EEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYN-V 444 E +R++ + S + + GE+ + + GNGP+ AV A+ Sbjct: 441 AEGP-YRMENYQRASVGDRSGSNFSWFINGEKHEL-SGQGNGPLSAVVHALKSSGLMPFF 498 Query: 445 ELVKYSLTAKGHGKDALGQVDIVANYNGRR-----FHGVGLATDIVESSAKAMVHVLNNI 499 +L +S G DA + +G G ++I ++ A+V +N Sbjct: 499 KLEDFSERTLGKDADAKALAFVGLRCGEDSEHTSLVYGAGEHSNIDRAAIAALVSAMNRA 558 Query: 500 WR 501 Sbjct: 559 VA 560 >UniRef50_B8FYI5 Pyruvate carboxyltransferase n=5 Tax=Bacteria RepID=B8FYI5_DESHD Length = 557 Score = 357 bits (916), Expect = 7e-97, Method: Composition-based stats. Identities = 112/533 (21%), Positives = 219/533 (41%), Gaps = 39/533 (7%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 ++ LRDG QAL +S++EKL+ L ++G +EVGFP +S ++ ++T Sbjct: 27 ITTPPTWCSVDLRDGNQALVVPMSLEEKLEYYHMLLKIGFKEIEVGFPAASETEYAFLRT 86 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + Q ++ + L + + I+ ++L + +H + +TS + + +E Sbjct: 87 LIEQNLIPEDVTIQVLTQSRDHIIEKTFKALVGVKKAVVHLYNSTSVAQREQVFKMSREE 146 Query: 118 VIERAIYMVKRARNYTDD------VEFSCEDAGRTPIADLARVVEAAINAGATT------ 165 ++E A+ + + Y + E+S E T + + ++ T Sbjct: 147 IVEIAVSGARLLKKYAAETEGNFQFEYSPESFTGTEMEFALEICNQVLDVFEPTPENKVI 206 Query: 166 INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQV 225 IN+P TV +MP +A I + E + D I+S+H H+D G AV ++ + AG +++ Sbjct: 207 INLPATVSLSMPHVYASQIEYMSEHLKYRDNVILSLHPHNDRGTAVADAELGLLAGGQRI 266 Query: 226 EGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANK 285 EG + G GER GN + + + + V +N + + + M + + Sbjct: 267 EGTLFGNGERTGNVDIVTLALNLFSHG----VDPGLNFASMLEITAKYEALTRMKVHDRQ 322 Query: 286 AIVGSGAFAHSSGIHQDGVLKNRENYE------------IMTPESIGLNQIQ--LNLTSR 331 G FA SG HQD + K + E ++ P+ IG + + S+ Sbjct: 323 PYGGKLVFAAFSGSHQDAITKGIKWREEHECHYWNVPYLLIDPQDIGREYEGDVIRINSQ 382 Query: 332 SGRAAVKHRMDEM-GYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEH 390 SG+ + + +++ + ++D + + F + Sbjct: 383 SGKGGIAYMLEQHYALDLPAKMREAFGYKVKNVSDNLHKELMPEEIKDIFFKEYVNIENP 442 Query: 391 FRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYS 450 + F ++D V L E++ + G+G +DA+ A+ + + Y Sbjct: 443 IKFLNFHFL--NHDDFQTTVTLEFKGEIQELSGEGDGRLDAISNALQARLGLSYSNLIYK 500 Query: 451 LTA--KGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWR 501 A G A+ V + +G G G+ TDI SS KA++ +N + + Sbjct: 501 EHALELGSKSQAVSYVGVT-GPDGVIHWGCGIHTDIFTSSVKALISAINTMIK 552 >UniRef50_C5S831 2-isopropylmalate synthase n=20 Tax=Bacteria RepID=C5S831_CHRVI Length = 534 Score = 357 bits (916), Expect = 7e-97, Method: Composition-based stats. Identities = 143/526 (27%), Positives = 226/526 (42%), Gaps = 27/526 (5%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIAL-ALERMGVDVMEVGFPVSSPGDFESVQTI 61 ++V+I DTTLRDGEQ S + EKL +A LE++ VD +EV S G+ +V I Sbjct: 21 RRVLIMDTTLRDGEQTQGVSFAPAEKLNLAKVLLEQVRVDRIEVASARVSSGEASAVAQI 80 Query: 62 AR------QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 V+ V D + + + A ++ S H +L TL Sbjct: 81 IDWARERGLVERVEVLGFV-----DGGASVDWICGAGGQVLNLLAKGSEKHCRGQLGKTL 135 Query: 116 DEVIERAIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTV 172 DE + A++ V ED R + +VE + G +PDT+ Sbjct: 136 DEHAADVRATIAAAQSRGLRVNLYLEDWSNGYRDNPDYVYGLVERLADVGIGHFMLPDTL 195 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G P + IS + R P++ H H+D GLA N LAAV AGA V +N + Sbjct: 196 GVMTPDQVFTAISDMVGRFPSLQ---FDFHPHNDYGLATANVLAAVQAGAAAVHCTVNCL 252 Query: 233 GERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 GERAGN SL EV + ++ D L+ I+ + R S+LV I N IVG+ Sbjct: 253 GERAGNASLAEVAVNLR---DQLDCALGIDETHLARVSELVESFSGKRISDNAPIVGADV 309 Query: 293 FAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYN 352 F ++GIH DG K + ++PE + + L +G+A++ ++ + + SE N Sbjct: 310 FTQTAGIHADGDKKGSLYHSRLSPERFARRR-KYALGKLAGKASLAKNLERLDIELSEEN 368 Query: 353 LDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKL 412 + ++L D K + DL + + ++ +H L +V S + + A +++ Sbjct: 369 QRKVLQRIVELGDSKKTITTEDLPFIIAEVLESKDYDHAELLSCTVSSSLDLESMAGIRI 428 Query: 413 ACGEEVKAEAANGNGPVDAVYQAINRITEYN----VELVKYSLTAKGHG-KDALGQVDIV 467 GE+V GNG DA A+ RI + L+ Y + G DAL + I Sbjct: 429 RLGEQVFTGTGTGNGGFDAFTNALGRILKRQGLTLPPLIDYEVRIPKGGRTDALTECSIT 488 Query: 468 ANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKA 513 G+ + V ++ A + +LN A E + A Sbjct: 489 WQTERGELRTRGVHANQVFAAIGATMRMLNIRMHRALAESRREGGA 534 >UniRef50_Q6KZ01 2-isopropylmalate synthase n=1 Tax=Picrophilus torridus RepID=Q6KZ01_PICTO Length = 375 Score = 353 bits (907), Expect = 8e-96, Method: Composition-based stats. Identities = 124/386 (32%), Positives = 194/386 (50%), Gaps = 19/386 (4%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + + D+TLR+GEQ S S+ +++IA AL GV ++E G P S +S+++I Sbjct: 2 IGLLDSTLREGEQTPGVSFSMDARVEIARALSDAGVSMIEAGHPAVSETVLKSIKSIMEL 61 Query: 65 ----VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 + S + A +R V DIDVAA I F S +H+ K T ++ I Sbjct: 62 KSSGIIRSTIVAHSRAVRSDIDVAA----SLNIDMIAIFYGISDLHLKYKTLKTREDAIR 117 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 + + AR+Y +V F+ EDA RT L V AA +AGA I+I DTVG P Sbjct: 118 IIVDSIDYARSYGLNVRFTAEDATRTDYNYLLDVARAARDAGAKRISIADTVGILNPDTS 177 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 + + + V N++ +H H+DLG+AV NS+AA AGA + +NG+GER+G Sbjct: 178 YKLFKMIIKDVKNVE---FDIHAHNDLGMAVANSIAAYRAGATIIHSTVNGLGERSGITP 234 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 + + A+K + I+ + ++ S LV + + +P N + G AF H SG+H Sbjct: 235 TQIIGPALKYHYN----EAVIDLKRLYSLSNLVEKYSGVMVPYNYPVTGKNAFTHKSGVH 290 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 G++ E YE M P G N+ ++S SGR AV R+ E+G ++ +L L Sbjct: 291 IAGIINKPETYEFMDPCLFG-NKRYYTISSYSGRHAVITRLQELGISLNDEHLKILMKMI 349 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQE 386 +K ++ D +L A+A K+ Sbjct: 350 K---NKNRELNDDELYAMAESIKRSA 372 >UniRef50_C8WE03 Homocitrate synthase n=3 Tax=Zymomonas mobilis RepID=C8WE03_ZYMMN Length = 402 Score = 353 bits (905), Expect = 1e-95, Method: Composition-based stats. Identities = 137/388 (35%), Positives = 201/388 (51%), Gaps = 13/388 (3%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + +II DTTLRDGEQA + ++ EKL IA AL+ GVD +E G P + E+++ I Sbjct: 7 KHLIINDTTLRDGEQAPGVAFTLSEKLHIAKALDEAGVDEIEAGIPAMGASEIEAIRQIV 66 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRS-TLDEVIER 121 +Q + +RV R D+D A E+ A +H I++SP +A K + +++ Sbjct: 67 QQSQTARVIPWCRMKISDVDKALET----GAKTVHLSISSSPFQMAAKFPDLSAADILGL 122 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 ++ A++ DV EDA R I+ L ++ AGA I DT+G PF Sbjct: 123 CQKVISYAKDRGLDVSVGAEDASRAEISFLTDLLGVIEEAGAFRIRFADTLGILDPFATY 182 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 IIS L++ I I H HDDLGLA NSLAA+ AGA+ + G+GERAGN L Sbjct: 183 EIISQLHQ----ISPLDIEFHGHDDLGLATANSLAAIKAGAKGASVTVLGLGERAGNAPL 238 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 E+V++A I T I ++++ +Q V+Q IP +KAIVG F H SGIH Sbjct: 239 EQVVIA---ASHIAGKETRILPEKLYNLAQYVAQAAGRTIPPDKAIVGEAVFQHESGIHV 295 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 G+L+N +YE + PE +G + ++ L SGRAA++H + +G K E + NL A Sbjct: 296 AGLLRNPASYEALNPEKLGRQR-EIVLGKHSGRAAIRHALSLLGIKAQEDMIQNLLAAVK 354 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPE 389 A + + AL +P Sbjct: 355 MQASHQKRAIGLSEIALIHQNFTHTQPN 382 >UniRef50_B7GT76 2-isopropylmalate synthase n=19 Tax=Bifidobacterium RepID=B7GT76_BIFLI Length = 638 Score = 351 bits (900), Expect = 4e-95, Method: Composition-based stats. Identities = 127/571 (22%), Positives = 216/571 (37%), Gaps = 78/571 (13%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + + LRDG QAL + + KL+ L MG +EVGFP +S DF+ ++ Sbjct: 68 LQRAPRWCSVDLRDGNQALVNPMDSERKLRFWNLLVSMGFKEIEVGFPSASETDFDFIRM 127 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + + + L +C E I E+LK A+ +H + + S + R +E Sbjct: 128 LIERELIPDDVTIVVLTQCREHLIRRTYEALKGAKRAIVHFYNSVSVLQREVVFRKNKEE 187 Query: 118 VIERAIYMVKRARNY-------TDDVEFSCEDAGRTPIADLARVVEAAINAGATT----- 165 + + A + ++ E+S E T V A I T Sbjct: 188 IKKLATDAAELCKDLENEAKGIDLYYEYSPESFTGTEPEYAVEVCNAVIGVIKPTPEHPM 247 Query: 166 -INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 IN+P TV T P FA + + + + D ++S+H H+D G+ V + AV AGA + Sbjct: 248 IINLPATVEMTTPNVFADEVEYVSTHLDDRDSVVLSLHPHNDEGMGVAATELAVLAGADR 307 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 VEG + G GER GN L V + + + ++ + + V + I Sbjct: 308 VEGCLLGNGERTGNVDL--VTLGLNWLTQ--GIDPQLDLSNVPEIRKTVEYCNQIKISER 363 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNRENYE--------------------IMTPESIGLN-Q 323 G+ F SG HQD + K E + + P+ IG + Sbjct: 364 HPYAGNFVFTAFSGSHQDAIKKGLEARQVAAERAGADLDSFVWLVPYLPIDPKDIGRTYE 423 Query: 324 IQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA--DKKGQVFDYDLEAL--- 378 + + S+SG+ + + + + L +D ++ K +V D D+ L Sbjct: 424 AIIRVNSQSGKGGMAYLLKTNHNLDLPKRLQIEFDKIVQNYADTTKKEVKDGDIWRLFKD 483 Query: 379 --------------AFIGKQQEEPEH----FRLDYFSVQSGSNDIATA--------AVKL 412 +G + +L +V SG + T V + Sbjct: 484 EYLPVEQSGMTAAGVVVGDTHDASLEPWGRLKLLKVAVSSGEDGSDTVLKARLLDRGVNV 543 Query: 413 ACGEEVKAEA-ANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVAN-- 469 E V+ EA GNGP+ A AI+ ++ Y G DA+ + Sbjct: 544 GDDEPVEREASGIGNGPIAAFLNAISNF-GVEASIMDYVEHTMSVGTDAMAASYVECQIG 602 Query: 470 --YNGRRFHGVGLATDIVESSAKAMVHVLNN 498 + + GVG+ + I S+ KA++ +N Sbjct: 603 EADDAQIVWGVGIDSSITTSALKAIISAINR 633 >UniRef50_C1SID8 Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SID8_9BACT Length = 376 Score = 350 bits (898), Expect = 7e-95, Method: Composition-based stats. Identities = 119/367 (32%), Positives = 178/367 (48%), Gaps = 12/367 (3%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 II DTTLRDGEQ + S KEKL I L+ +GV +E G PV + ++I Sbjct: 2 IIDDTTLRDGEQTPGVAFSRKEKLTIVKHLDAIGVQEIEAGIPVMGLAESRMFESIMELG 61 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 ++R+ A R + D+ + A A I + S + I TKL T ++++ + Sbjct: 62 LDARIIAWNRALIGDVQASI----AAGANSIEISLPMSDVQINTKLNKTRGWILDQVKSV 117 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 + N+ + EDA R LA + GA DTVG PF+ + + Sbjct: 118 LDFCANHDLYISVGGEDASRADFDFLAEYIRTIEAHGADRFRFCDTVGILDPFKTYELTA 177 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245 + E I I +HTH+D G+A N+LAAV AGA V + G+GERAGN LEE+I Sbjct: 178 KIRE----ITSMDIEIHTHNDFGMATANALAAVRAGATHVNTTVIGLGERAGNAPLEEII 233 Query: 246 MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVL 305 MA + + + A + + + S+ V+Q + + ++G F H SGIH DGVL Sbjct: 234 MA---SRHVYGMDDAFDTKTMRSLSEYVAQAAGRNLDPQRPVIGEFMFTHESGIHTDGVL 290 Query: 306 KNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLAD 365 KN +NYE P + + + L ++SG A +K+ +++ G Y L L KLA Sbjct: 291 KNPKNYEAFDPAELNMQRN-LVFGNQSGLAVLKYILEQEGIVLESYQLTGLLHEAKKLAR 349 Query: 366 KKGQVFD 372 K V + Sbjct: 350 KNKAVLN 356 >UniRef50_B4S9H2 Pyruvate carboxyltransferase n=13 Tax=Bacteria RepID=B4S9H2_PROA2 Length = 390 Score = 349 bits (896), Expect = 1e-94, Method: Composition-based stats. Identities = 117/373 (31%), Positives = 183/373 (49%), Gaps = 12/373 (3%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + V I DTTLRDGEQA + + +EK IA L GV+ +E+G+P S + + IA Sbjct: 13 RPVWIIDTTLRDGEQAPGVAFTPEEKKTIAGKLAECGVNELEIGYPAISSEEQAVITEIA 72 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 R R+ + AR +DID A + +H S +++ + + V E+ Sbjct: 73 RMQLPLRLTSWARAKWEDIDAAIR----CKTQGVHISFPLSELYLQL-MDKPYEWVEEQL 127 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 +V +A+ Y D V +DA RT L R + A+ GA I I DTVG P Sbjct: 128 HLLVPKAKKYFDFVSVGGQDATRTGPDILERFIREAVECGADRIRIADTVGIATPLHLMQ 187 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 +IS + + VP A + H H+DLG+A N+ +A+ AG V ++ G+GERAGN +LE Sbjct: 188 LISRIKKAVP----ATLEFHAHNDLGMATANAFSAMEAGCDAVSVSVTGLGERAGNAALE 243 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E+ +A+K+ H++I + + +V++ N I K ++G+ F H SGIH + Sbjct: 244 ELAIALKLSG---RYHSSIKTERLQELCGIVAKASNRNIEDQKPVIGASVFRHESGIHCN 300 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 +LKN +Y+ P IG + +L + SG AA++H + G L Sbjct: 301 ALLKNPLSYQPFLPGEIGRDNYELVIGKHSGSAAIQHVLAGNGIAIDRKEASRLLAPVRM 360 Query: 363 LADKKGQVFDYDL 375 AD+ + D Sbjct: 361 TADRNKRGISADE 373 >UniRef50_B9LUZ7 Pyruvate carboxyltransferase n=1 Tax=Halorubrum lacusprofundi ATCC 49239 RepID=B9LUZ7_HALLT Length = 387 Score = 349 bits (896), Expect = 2e-94, Method: Composition-based stats. Identities = 146/390 (37%), Positives = 216/390 (55%), Gaps = 15/390 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V IFDTTLRDGEQ+ + S S EK +IA L+ M V+E GFPV+S +FE+V IA Sbjct: 10 VRIFDTTLRDGEQSPRTSFSYDEKRRIAATLDDMNTHVIEAGFPVNSDAEFEAVSDIAA- 68 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 N+ VC LAR VE DID A +S +H F++TS + + + +T E +RA+ Sbjct: 69 ATNTTVCGLARVVEGDIDAAIDS----GVEMVHVFVSTSDVQLEDSMHATRQEAKQRAVA 124 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 V++ ++ + FS DA RT L +VEA +AG INIPDT G MP F + Sbjct: 125 AVEQVKDAGVECMFSPMDATRTDPDYLREIVEAVSDAGTDWINIPDTCGVAMPTSFGKTV 184 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + N A + VHTHDD G+A N++ GA Q + ++NGIGERAGN + EEV Sbjct: 185 KAVV----NATDARVDVHTHDDFGMAAANAVMGFENGAEQAQVSVNGIGERAGNAAYEEV 240 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 +MA++ + V T I+ +I + +++V + ++P+PANK + G AFAH SGIH GV Sbjct: 241 VMAVE---SVYGVDTGIDTTQITKLARIVEEASDIPVPANKPVTGRNAFAHESGIHAAGV 297 Query: 305 LKNRENYE--IMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 ++N + +E +MTPE +G + + L +G +V+ + E G+ ++ + + + Sbjct: 298 IENADTFETGVMTPEMVGAER-EFVLGKHTGTHSVRKHLVEAGFDPTDSEVRRITKRVKE 356 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFR 392 K QV D+E A E E R Sbjct: 357 YGSGKRQVTAGDVERFAEEADIDREEEEVR 386 >UniRef50_B8FAB3 Pyruvate carboxyltransferase n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FAB3_DESAA Length = 374 Score = 349 bits (895), Expect = 2e-94, Method: Composition-based stats. Identities = 114/368 (30%), Positives = 186/368 (50%), Gaps = 11/368 (2%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V I DTTLRDGEQA + +EK+ +A+ L++ VD +EVG P P + ++ IA Sbjct: 7 VHIIDTTLRDGEQAPGVAFDKREKIALAMMLDQAHVDELEVGIPAMGPAAQDEIKAIAGL 66 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 + + A R ++ DID + + +H S +H+ + T V+ + Sbjct: 67 NPDCLLTAWCRALKDDIDQSL----LCNVTGVHISFPVSDIHLEA-MGKTRSWVLNQLSV 121 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 ++ A V +DA R +A L + V +A GA + I DTVG P + ++ Sbjct: 122 LIPYALQRFSRVSVGAQDAFRADMAFLEQFVHSANLRGAHRVRIADTVGLARPSQVENMV 181 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 L + + + H H+DLG+A N++AA+ AGA+ V +NG+GERAGN LE+V Sbjct: 182 HVLSKAAGKM---ALEFHGHNDLGMATANTIAAIEAGAQAVSVTVNGLGERAGNAPLEQV 238 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 ++A + + T ++ + + + V++ N PIPA++ I G F H SGIH G+ Sbjct: 239 VVA---AGTLDSRSTCVDARRLSEICRYVAEAVNRPIPADQPITGQAVFTHESGIHCAGI 295 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 LKN + Y+ PE++G + QL + SG ++H + + G + E ++L A A Sbjct: 296 LKNPDTYQPFNPETVGRERAQLVIGRHSGSGMIRHVLAKAGVRLEEGKTESLMAAVRMEA 355 Query: 365 DKKGQVFD 372 KK V Sbjct: 356 LKKRSVLS 363 >UniRef50_B0CSN8 Predicted protein (Fragment) n=11 Tax=cellular organisms RepID=B0CSN8_LACBS Length = 603 Score = 348 bits (894), Expect = 3e-94, Method: Composition-based stats. Identities = 125/576 (21%), Positives = 218/576 (37%), Gaps = 84/576 (14%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 ++ I T LRDG QAL ++V++K L + GV +EV +P +S DF+ V+ Sbjct: 23 LTNVPIWLSTDLRDGNQALANPMTVEQKTTFFRQLVKCGVKQIEVAYPAASETDFQFVRG 82 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + + L E I +S+ A+ +H + ATSP RS+ ++ Sbjct: 83 LIENNEVPDDVWIQVLTPAREDLIRRTIDSVAGAKHAILHMYNATSPTFREVVFRSSKEQ 142 Query: 118 VIERAIYMVKRARNYTDDV----------EFSCEDAGRTPIADLARVVEAAINA------ 161 I+ A+ K R T++ E+S E +T V EA A Sbjct: 143 TIKLAVEHTKIVRQLTEECTAKYGTVFKYEYSPETFTQTEPEYALEVCEAVKAAWGKAGT 202 Query: 162 GATTI--NIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVH 219 G I N+P TV P +A I + +K IIS+H H+D G A+ ++ + Sbjct: 203 GDDRIIFNLPSTVEIAPPNHYADQIENFCRNISEREKIIISLHPHNDRGTAIASAELGML 262 Query: 220 AGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNM 279 AG ++EG G GER GN L + + + ++ ++ +I +V+Q ++ Sbjct: 263 AGGDRIEGCFFGNGERTGNVDLVNLALNFYSQG----INPGLDFSDIQSVIDVVTQCNDL 318 Query: 280 PIPANKAIVGSGAFAHSSGIHQDGVLKN----------------RENYE----IMTPESI 319 P+ G F SG HQD + K + + + P + Sbjct: 319 PVHPRHPYAGELVFTAFSGSHQDAIKKGFEVQKIRHAQAAAQGEPQYWNIPYLPIDPADL 378 Query: 320 GLN-QIQLNLTSRSGRAAVKHRMDE-MGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEA 377 G + + + + S+SG+ + + + + Y +ADK+ + D Sbjct: 379 GQDYEAVIRVNSQSGKGGIAFLIKQHLHLDLPRKMQVLFYQVVQAIADKEAREMTVDDIT 438 Query: 378 LAFIGKQQEEPEHF----RLDYFSVQSGSNDIA-------------TAAVKLACGEEVKA 420 AF + + L F + + D L+ + Sbjct: 439 TAFRRTYKFGGSKYAGRLVLRNFRISTERGDDPAEFSGDDAPDERRRFDGTLSVDGVYRV 498 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLT---------------AKGHGKD--ALGQ 463 +GNGP+ A+ A+ + + + Y A G G + A Sbjct: 499 IRGDGNGPLSALLDALRTHLDIDYTIRDYIEHSLSVGFNGQSGQADIAIGEGTEVVAASY 558 Query: 464 VDIVANYNG---RRFHGVGLATDIVESSAKAMVHVL 496 V+++ G R GV TDI S KA+++ + Sbjct: 559 VELLYEVEGSKKRSAWGVATDTDITASGIKAVLNAV 594 >UniRef50_B0TAQ1 Homocitrate synthase, nifv n=4 Tax=Clostridiales RepID=B0TAQ1_HELMI Length = 380 Score = 347 bits (891), Expect = 6e-94, Method: Composition-based stats. Identities = 110/381 (28%), Positives = 174/381 (45%), Gaps = 13/381 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M Q+V + DTTLRDGEQ + +EK +A L GV +E G P + E++ Sbjct: 1 MRQRVWLMDTTLRDGEQTPGVAFCPQEKALLARRLAEAGVHEIETGVPAMGEDEQETIAR 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I + +RV R V D++ + + + +S I KLR + V++ Sbjct: 61 IVKLNLPTRVTTWNRAVISDLEASLN----CGVRSVAICLPSSDQQITQKLRQSRQWVLD 116 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 + V+RA+ V EDA R L ++ A + I DT+G P Sbjct: 117 QMGACVRRAKAEGLYVVIGLEDASRADPQFLIQLGLEAERLKVNRLRISDTLGILDPIRT 176 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 + L + + +H H+DLG+A N+++A+ AGA+ + G+GERAGN Sbjct: 177 FNLFDRLTSSL----SIPLEIHAHNDLGMATANTVSAIQAGAKAASVTVCGLGERAGNAP 232 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV +A++ T IN + +LVS PIP +K +VG AF H+S IH Sbjct: 233 LEEVALALR---QCCAADTRINLALLPALCRLVSWSTRRPIPFSKPVVGRDAFTHASSIH 289 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 DG+ K+R NYE PE +G + ++ SGR + + G+ + + L Sbjct: 290 VDGLNKDRSNYEAYPPEYVGR-RHRIAFGKYSGRKLLAELLKAQGHDLDQEEMTQLLLNV 348 Query: 361 LKLADKKGQVF-DYDLEALAF 380 +L+ + +D+ L F Sbjct: 349 RQLSQVLKRPLRQHDIVDLIF 369 >UniRef50_B8I2I3 Pyruvate carboxyltransferase n=1 Tax=Clostridium cellulolyticum H10 RepID=B8I2I3_CLOCE Length = 388 Score = 344 bits (884), Expect = 4e-93, Method: Composition-based stats. Identities = 109/381 (28%), Positives = 190/381 (49%), Gaps = 17/381 (4%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 + DTTLRDGEQ + ++K++IA L++ G++ ++ GF +S + S++ I Sbjct: 16 KFFFCDTTLRDGEQVSGIRYTPEQKVEIAQMLDKAGIESIDAGFAATSEEERLSIRKICD 75 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRST----LDEVI 119 R+ ++ R + +DID A + FI S +H+ K ++ Sbjct: 76 LGLKMRIMSMCRVIREDIDFA----SSCGVEGVILFIPGSDIHLKAKFGEDIPAVRKNIV 131 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE 179 ++A+ +K A++ VEF ED+ RT L ++ A GA + DT+GY P Sbjct: 132 QKAMDAIKYAKDKGLFVEFGVEDSTRTDFNVLLEILSQAEQEGADILGTTDTIGYLTPER 191 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 I L + K I VH H+D+GLA N++A + AG +NG+GERAGN Sbjct: 192 TYNFIKKLVRNL----KLPIGVHCHNDMGLATANTIAGLLAGGGYCSPTVNGMGERAGNA 247 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 SLEEVIM +KV + N + + + S+ V + + + K IVG A++H SGI Sbjct: 248 SLEEVIMILKV---LYNQDLKYDTKILGELSKTVEKYSGISMDIFKPIVGQNAYSHESGI 304 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 H G+LK+ YE+ P+ +G ++ + + +G+ ++H + G++ SE +++ + Sbjct: 305 HVHGMLKDINTYELFDPQLVGHSR-KYEMGKHAGKHTIQHILKTNGFELSEEEVED-FWR 362 Query: 360 FLKLADKKGQVFDYDLEALAF 380 +K +K G + + + Sbjct: 363 HMKSNEKAGVYYSVEDVITEY 383 >UniRef50_Q5KCL7 2-isopropylmalate synthase, putative n=1 Tax=Filobasidiella neoformans RepID=Q5KCL7_CRYNE Length = 639 Score = 343 bits (880), Expect = 1e-92, Method: Composition-based stats. Identities = 120/610 (19%), Positives = 212/610 (34%), Gaps = 108/610 (17%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + I T LRDG Q+L ++ ++KL+ L ++G +EV +P +S D+ V+ + Sbjct: 31 KAPIWLSTDLRDGNQSLANPMTNQQKLRFFRHLVQLGFKEIEVAYPAASETDYNFVRELI 90 Query: 63 RQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + + + L I E++ + +H + ATS + + DE I Sbjct: 91 DRKEVPDDVWIQVLTPARADLIKRTFEAVAGLKHVIVHMYNATSCLFREVVFNNDRDETI 150 Query: 120 ERAIYMV--------KRARNYT--DDVEFSCEDAGRTPIADLARVVEAAINAG------- 162 + A+ K A ++ E+S E +T V EA A Sbjct: 151 KLAMDHTILIRQLAEKYAESHGTSFRYEYSPETFSQTETPYAVEVCEAVKKAWLGGHGSV 210 Query: 163 -AT-------TINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNS 214 A N+P TV P FA + + +K IIS+HTH+D G AV + Sbjct: 211 WADGRKEERIIFNLPATVEVATPNCFADQVEIFCNSISEREKCIISLHTHNDRGCAVAAA 270 Query: 215 LAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVS 274 V AGA ++EG + G GER GN L + + + + ++ +++ V+ Sbjct: 271 ELGVLAGADRIEGTVLGNGERTGNVDLVTLALNCYSQG----ISPNLDFSDMFSVIDTVT 326 Query: 275 QICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNREN---------------YEIMTPESI 319 + +P+ G F SG HQD + K E Y + P + Sbjct: 327 ECTGLPVHPRHPYAGELVFTAFSGSHQDAIKKGFEAQAKRDHAGDQVWSMPYLPIDPADV 386 Query: 320 GLN-QIQLNLTSRSGRAAVKHRMDE-MGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEA 377 G + + + S+SG+ + + + + Y + ++ G+ Sbjct: 387 GCTYEAVIRVNSQSGKGGIAYIVKSALSLDLPRRMQIAFYKVVQECSEATGREMTSKDIT 446 Query: 378 LAFIGKQQE----------EPEHFRLDYFSVQS----GSNDIATA--------------- 408 AF +D FS Q+ G+ D++ Sbjct: 447 TAFRQTYHLGGSIYDGRLVLKSFVTVDLFSSQTPSVAGTPDLSPIRSRSQTRMPPLSLSS 506 Query: 409 ----------------------AVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVEL 446 K+ ++ GNGP+ + A+ + + Sbjct: 507 SVAEPSPDRSLDRNLPSMSKRLTAKVLVDGKLHEIVGEGNGPLSSFLNALESDLGIVLSV 566 Query: 447 VKYSLTAKGHGKDALGQVDIV-----ANYNGRR---FHGVGLATDIVESSAKAMVHVLNN 498 +Y+ A G G D + + + F GVG+ DI S KA+V N Sbjct: 567 REYTEHAVGAGSDVKAATYVELIPANVDAKDKTQGGFWGVGVDADITASGLKAVVSAANG 626 Query: 499 IWRAAEVEKE 508 + + Sbjct: 627 FLGQGPIPSQ 636 >UniRef50_UPI000038E0D5 2-isopropylmalate synthase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0D5 Length = 377 Score = 339 bits (870), Expect = 2e-91, Method: Composition-based stats. Identities = 108/365 (29%), Positives = 179/365 (49%), Gaps = 17/365 (4%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M +V I D+TLR+GEQ + ++++IA L V ++E G P+ SP + +++ Sbjct: 1 MPLKVGILDSTLREGEQTPGVLFNKNQRIEIAQLLSDAHVAMIEAGHPLVSPDIYSAIKE 60 Query: 61 I----ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 I A + NS + A +R V DID AA RI F S +H+ K + Sbjct: 61 IMDMKASGMINSEIIAHSRAVNSDIDSAA----SLGVDRIAIFYGVSDIHLDNKTHRSRT 116 Query: 117 EVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTM 176 E ++ + A + V F+ EDA RT I L VV A++AGA ++I DT+G Sbjct: 117 EALDIIYDSISYASSTGIPVRFTAEDASRTDINFLRNVVRTAVDAGADRVSIADTLGILT 176 Query: 177 PFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERA 236 P + A ++ + +I H H+D+G+A+ N LAA +GA + +NG+GER Sbjct: 177 PEKTA----YIFNNLSDIKGVEYDFHGHNDMGMALANGLAAAESGATIIHSTVNGLGERV 232 Query: 237 GNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHS 296 G + + + + + AIN + S+L+ + + +P N + GS AF H Sbjct: 233 GIIPTQALGVLLNYHLGVD----AINLLSLKPLSELIEKYSGITMPPNYPVTGSTAFTHK 288 Query: 297 SGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNL 356 SG+H DG+++N YE M P +GL Q + SG+ A++ ++ MG + + + Sbjct: 289 SGVHVDGIIRNPGTYEFMDPSRLGL-QHSFTIDKYSGKHALREKLANMGINADDNKISYM 347 Query: 357 YDAFL 361 + Sbjct: 348 LEKIK 352 >UniRef50_D1XS06 2-isopropylmalate synthase n=1 Tax=Streptomyces sp. ACTE RepID=D1XS06_9ACTO Length = 612 Score = 339 bits (869), Expect = 2e-91, Method: Composition-based stats. Identities = 115/538 (21%), Positives = 199/538 (36%), Gaps = 45/538 (8%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +++ + LRDG QAL + K ++ L MG +EVG+P +S DF V+ Sbjct: 74 LTRAPLWVPVDLRDGNQALAEPMDAARKRRMFDLLVAMGFKEIEVGYPSASETDFGFVRH 133 Query: 61 IARQV---KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 +A + V ID S++ +H + AT+P+ L + E Sbjct: 134 LAESGAVPDDVTVSVFTAARSDLIDRTIASVEGLPRTLVHLYTATAPVWRDVVLGRSRAE 193 Query: 118 ----VIERAIYMVKRARNY---TDDVEFSCEDAGRTPIADLARVVEAAINAG------AT 164 + + A ++++RA EFS E T + V ++ Sbjct: 194 LHAMITDAATHLLRRAGERPGADIRFEFSPEVFNLTEPDFVLEVCDSLTELWEASPDRPV 253 Query: 165 TINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 N+P TV P +A I ++ + D I+SVH H+D G V + AV AGA++ Sbjct: 254 VHNLPATVEIATPNVYADQIEYMHRHLARRDSVILSVHPHNDRGTGVACAELAVLAGAQR 313 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 VEG + G GER GN L + + + + V ++ +I ++V +P+ Sbjct: 314 VEGCLFGNGERTGNVDLVTLALNLFAQG----VDPMVDFSDIDAVREVVEHCNRLPVHPR 369 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNRE--------------------NYEIMTPESIGLNQI 324 G SG HQD + K Y + P IG Sbjct: 370 HPYGGELVHTAFSGTHQDAIAKGMARHAKRAAEQGVPAAEAPWEVPYLPVDPGDIGRTYE 429 Query: 325 Q-LNLTSRSGRAAVKHRMD-EMGYKESEYNLDNLYDAFLKLADKKGQVFDY-DLEALAFI 381 + + + S+SG+ V H + G + + ++ D G+ +L L Sbjct: 430 EVIRINSQSGKGGVAHLLRAHHGLDLPQAMRPDFSRTVQRVTDGTGRELTAGELGELFRT 489 Query: 382 GKQQEEPEH-FRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRIT 440 + +S + + T L + GNGP+ A+ A+ Sbjct: 490 TYLAAAGQGSVEAVSWSTAETAPGVHTFTCVLRVDGREHSCRGTGNGPLAALTDALRTA- 548 Query: 441 EYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNN 498 V ++ Y A G D+ +G G G T ++ +S +++ +N Sbjct: 549 GVTVGVLGYWEHATTAGPDSPAAAYAECRVDGVTAWGAGWDTSVLTASVHSVLSAVNR 606 >UniRef50_Q56216 2-isopropylmalate synthase (Fragment) n=1 Tax=Thermus thermophilus RepID=LEU1_THETH Length = 331 Score = 336 bits (863), Expect = 9e-91, Method: Composition-based stats. Identities = 136/313 (43%), Positives = 187/313 (59%), Gaps = 2/313 (0%) Query: 188 YERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMA 247 + V +IS HTHDDLG+A N+LA V GA Q+E +NGIGERAGNC+LEEV+MA Sbjct: 1 RDEVVRGRDVVISTHTHDDLGMATANALAGVENGAGQIECTINGIGERAGNCALEEVVMA 60 Query: 248 IKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKN 307 + VR+D +T IN +EI+R S+LV + MP+P NKAIVG AFAH SGIHQDGV+K+ Sbjct: 61 LYVRRDWYKAYTRINTREIYRVSRLVERYTGMPVPPNKAIVGDNAFAHESGIHQDGVIKH 120 Query: 308 RENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK-ESEYNLDNLYDAFLKLADK 366 R YEIM E IG L L SGRAA K ++++GYK SE + L+ F ++A+K Sbjct: 121 RATYEIMDAELIGRRPAVLVLGKHSGRAAFKKALEDLGYKDLSEEEVKKLFARFKEIAEK 180 Query: 367 KGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGN 426 KG + +L+AL ++ F+L++ SGS + TA VK+ + + G+ Sbjct: 181 KGPLSAEELQALVESEREPTSH-FFQLEHVQFFSGSGLLPTATVKVKTPDGERLATHTGD 239 Query: 427 GPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVE 486 GPVDAVY+AI EL Y + A +ALGQV + + GVG++ DI+E Sbjct: 240 GPVDAVYKAIQEAIGLRPELELYRVEAITGSTEALGQVTVRLRLGELQAVGVGVSPDIIE 299 Query: 487 SSAKAMVHVLNNI 499 +SA A + + Sbjct: 300 ASALAFLDAAGKL 312 >UniRef50_Q0ZQ46 FrbC n=3 Tax=Bacteria RepID=Q0ZQ46_9ACTO Length = 373 Score = 336 bits (861), Expect = 2e-90, Method: Composition-based stats. Identities = 104/374 (27%), Positives = 176/374 (47%), Gaps = 12/374 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M +++ DTTLRDGEQ + S + K I AL GV +E+G P + + +++ Sbjct: 1 MRNDLVLEDTTLRDGEQTPGVAFSKETKTAILNALIEAGVTSIEIGIPAMGGEELDFIKS 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 + + +R+ R V +D++ + + +H + TS H+ +R ++ Sbjct: 61 VVDRQDEARLVVWHRGVREDVERSLD----LGFTSVHVGLPTSAGHLKASVRKDRTWLLA 116 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 A MVK A++ V S ED RT I+ L AGA + + DTVG P + Sbjct: 117 TARDMVKMAKDRGAFVSISAEDIARTEISFLQEYAGVVAEAGADRLRLSDTVGLLGPEAY 176 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 ++ + + H H+D GLA N+LA + AGAR +N IGERAG Sbjct: 177 GERVAAVLSAA----DIDVQCHAHNDFGLATANTLAGLKAGARYFHVTVNAIGERAGMAD 232 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 L +V++A+K D I+ ++ + S+LV++ + + I G FAH SGIH Sbjct: 233 LAQVVVALKKLYD---RDLGIDLTKLKKVSRLVAEAAGHQVLPWQPITGDNVFAHESGIH 289 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 +G+ ++ ++E PE +G + + L SGRA V +++ G E L + + Sbjct: 290 ANGMFRDTSSFEPFPPEHVGGER-RYVLGKHSGRALVAWALEQEGITPREELLPHCLEEV 348 Query: 361 LKLADKKGQVFDYD 374 L+ + G ++ Sbjct: 349 RALSIRIGGAVSHE 362 >UniRef50_Q1QBL0 2-isopropylmalate synthase n=5 Tax=Bacteria RepID=Q1QBL0_PSYCK Length = 594 Score = 334 bits (857), Expect = 4e-90, Method: Composition-based stats. Identities = 118/544 (21%), Positives = 218/544 (40%), Gaps = 55/544 (10%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + + I LRDG QAL +++++K++ L +G +E+GFP ++ +F+ + Sbjct: 47 LEKSPIWASVDLRDGNQALIDPMTIEQKMRFFETLIDVGFKEIEIGFPSAAQVEFDFARK 106 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + + + L + E I ESLK A+ +H + +T + E Sbjct: 107 LIEENHVPDDVTLQVLVQAREHLIARTFESLKGAKRAIVHVYNSTCRIQREKVYAKDKAE 166 Query: 118 VIERAIY----MVKRARNYTDD---VEFSCEDAGRTPIADLARVVEAAINAGATT----- 165 + E A+ +V+ A Y + ++S E +T V +A + Sbjct: 167 IKEIAVTGAKLLVEYAAKYPETEWVFQYSPESFSQTETEYAVEVCDAVCDVWRPENGQEV 226 Query: 166 -INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 +N+P TV +MP FA + + + IS+HTH+D G AV + V AGA + Sbjct: 227 ILNLPATVEASMPNVFADQVEYFCRNLAKREHVTISLHTHNDRGCAVAAAELGVLAGADR 286 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 +EG + G GER GN + + M + + + ++ + Q+VS+ N+P+ Sbjct: 287 IEGTLLGNGERTGNMDIMVMAMNLFSQG----IDPELDFSNMSEIVQVVSECNNLPLHPR 342 Query: 285 KAIVGSGAFAHSSGIHQDGVLK----NRE-----------NYEIMTPESIGLNQIQLN-L 328 VG F SG HQD + K N + Y + P IG + + + Sbjct: 343 HPYVGELVFTAFSGSHQDAIKKCLDYNEKHVEKTENVWDVAYLPIDPAHIGRSYQDVVRI 402 Query: 329 TSRSGRAAVKHRMDE-MGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEE 387 S+SG+ V + + G+ + + K A+ + D F ++ Sbjct: 403 NSQSGKGGVAYILQRNYGFNLPRWMQIDFSGVVQKQAETTARELQNDEILQTFEDTYLQQ 462 Query: 388 PEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELV 447 LDY G V++ G+ + + +GNGP+ + + + T ++ ++ Sbjct: 463 GSFELLDYTVNNKGGEVYFNGQVQM-NGDTITID-GDGNGPLSSFIDGLAQHTGKSIHVI 520 Query: 448 KYSLTAK------GHG----------KDALGQVDIVANYNGRRFHGVGLATDIVESSAKA 491 Y+ A G G +A I N +G + G+G + V + K Sbjct: 521 NYAEHAINPQHNSGDGINDDNNRDNKTNANAAAYIQLNVDGEVYSGIGTCSSTVSAMLKG 580 Query: 492 MVHV 495 + Sbjct: 581 ALSA 584 >UniRef50_A6FCI3 2-isopropylmalate synthase n=1 Tax=Moritella sp. PE36 RepID=A6FCI3_9GAMM Length = 387 Score = 333 bits (853), Expect = 1e-89, Method: Composition-based stats. Identities = 120/375 (32%), Positives = 199/375 (53%), Gaps = 4/375 (1%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ I DTTLRDGEQA + ++ ++KL++AL LE GVD +E GFP SS D+E+ + I+ Sbjct: 2 KKISILDTTLRDGEQAPENAMDPEKKLKMALMLEECGVDHIETGFPASSKFDYEATKLIS 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 ++V S + +R + D+ ++ ES + I S +H+ K + + IE Sbjct: 62 KEVTQSGIATFSRTLTSDVQLSLESGGREKNHTIQMVATGSDLHLKNKRNISRSQAIEEV 121 Query: 123 IYMVKRARNYTDD-VEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 I VK A+ +D + EDA R + + EAA+ AGA I + DT GY P EF Sbjct: 122 INTVKFAKQNSDCRIAVGIEDASRADFDFMGEITEAAVFAGAHQIILADTTGYATPSEFK 181 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 +I + + D IS H H+DLGLA N+LA + GA +V+ + GIGERAGN SL Sbjct: 182 KLIQFIRSKTG--DGISISTHCHNDLGLAHANTLAGIEGGADEVQVTLGGIGERAGNASL 239 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 E + + + + + T I ++++ Q + + IP N+ + G+ AF+ ++GIHQ Sbjct: 240 EMIASTLFFKPECYSSFTDIKLDKLYKVYQELCSEIGLDIPRNQPVFGTYAFSTAAGIHQ 299 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 GVL N + YE + P+ + + ++ SG++ +K+ + + L+ LY + Sbjct: 300 QGVLANPDTYEFVKPDVFNRER-EFFVSRHSGKSIIKYILSNKAMDQDPKLLETLYANCI 358 Query: 362 KLADKKGQVFDYDLE 376 + + +LE Sbjct: 359 SSRAENSCLSMIELE 373 >UniRef50_A6DIP7 2-isopropylmalate synthase n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DIP7_9BACT Length = 554 Score = 333 bits (853), Expect = 1e-89, Method: Composition-based stats. Identities = 118/522 (22%), Positives = 225/522 (43%), Gaps = 44/522 (8%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 ++Q LRDG QAL L++++K L ++G +E+GFP +S D++ + Sbjct: 22 ITQSPTWCAVDLRDGNQALPDPLTLEQKKIYFDILVKIGFKEIEIGFPSASKDDYDFCRH 81 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + + L + ++L+ +H ++ATS +H L + E Sbjct: 82 LIDNKVIPDDVMISVLVPARPDLVVKTMDALRDVPKATVHFYVATSDLHREHVLGKSHQE 141 Query: 118 VIERAIYMVK-------RARNYTDDVEFSCEDAGRTPIADLARVVEAAINAG---ATT-- 165 V E V+ + + T +EFS E+ T + V + I A Sbjct: 142 VFEMCTATVQSIKEEASKLKESTFYLEFSPEEFTDTDLDFAVEVCDHVIEQWQPAADEKV 201 Query: 166 -INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 +N+P TV P +A +I L++R ++AIIS+H H+D+G AV ++ A+ AGA + Sbjct: 202 ILNLPATVERRPPTHYADMIE-LFQRKLKSEQAIISLHAHNDMGCAVASTQLAIQAGAHR 260 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 VEG + G GER+GN L +++ ++ + T ++ ++ ++ +S++ NMP Sbjct: 261 VEGTLFGQGERSGNVDLITLVLNLQYLG----IDTGLDFSDLMNITEQISELTNMPPHER 316 Query: 285 KAIVGSGAFAHSSGIHQDGVLKN--------------RENYEIMTPESIGLN-QIQLNLT 329 VGS F+ SG HQD + K+ + Y + P +G + + + Sbjct: 317 HPYVGSLVFSAFSGSHQDAIHKSTLRKDELMETFGRWKIPYLHIDPADVGREFENLIRIN 376 Query: 330 SRSGRAAVKHRMD-EMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEP 388 S+SG+ + H ++ E K + + A++ + F P Sbjct: 377 SQSGKGGIAHIIEKEHNIKLPRFVQVDFAKRVQAYAEEVSREVSTQEVWKVFEEAYIA-P 435 Query: 389 EHFRLDYFSV----QSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNV 444 ++ +L + ++I A +++ E A GNGP+ A A+ ++ + Sbjct: 436 KNPKLVLNNYWPYPDEDQSEIVNAKIEVEFKGETFTHEATGNGPISAFVAALKKLDIPDF 495 Query: 445 ELVKYSLTAKGHG--KDALGQVDIVANYNGRRFHGVGLATDI 484 L + + G +A+ + + + NG G G ++I Sbjct: 496 VLEHFGEDSIGDSAQAEAVSSISVKNSDNGSVHIGFGYHSNI 537 >UniRef50_P54610 Homocitrate synthase n=6 Tax=Frankia RepID=NIFV_FRASP Length = 401 Score = 332 bits (852), Expect = 2e-89, Method: Composition-based stats. Identities = 115/369 (31%), Positives = 168/369 (45%), Gaps = 17/369 (4%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V DTTLRDGEQA + + EKL IA AL+ +GV +E G P + + ++ I Sbjct: 22 VRFCDTTLRDGEQAPGVAFTAAEKLAIAGALDAIGVHQIEAGIPGMGVTERDVLREILAT 81 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 + + R +D++ AA H I S +H+ +KL R Sbjct: 82 DPKAEIVGWCRADHRDVEAAA----SCGLVTAHLTIPVSDLHLKSKLERDRAWARRRVRD 137 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 V + V EDA R A + + + G T + DTVG P + Sbjct: 138 CVVDGTDRGMRVSVGFEDASRADDAFVTDLAGELRDVGVTRLRWADTVGLLDPVSAYDRL 197 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 L VP +H HDD GLA N++AAV AG V + G+GERAGN +EEV Sbjct: 198 GRLVRAVPG----PWEIHAHDDFGLATANTIAAVQAGFTWVSTTVLGLGERAGNAPIEEV 253 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA-NKAIVGSGAFAHSSGIHQDG 303 MA++ +L + ++ +QLV P+PA KA+VG FAH SGIH G Sbjct: 254 AMALR---HLLKLPIDLDTTSFRTLAQLV---VGWPLPAGKKAVVGESVFAHESGIHVHG 307 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 +L++ YE PE G + L + SGRA+++H +++ G E L+ L + Sbjct: 308 ILRHPATYEPFDPEVGGRRR--LTVGKHSGRASLRHALEQCGITAEESELEPLVEQVRLA 365 Query: 364 ADKKGQVFD 372 A + + D Sbjct: 366 ATRHKRGLD 374 >UniRef50_Q9V1J1 2-isopropylmalate synthase 2 n=5 Tax=Thermococcaceae RepID=LEU12_PYRAB Length = 361 Score = 330 bits (847), Expect = 6e-89, Method: Composition-based stats. Identities = 101/343 (29%), Positives = 176/343 (51%), Gaps = 14/343 (4%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 ++ D+TLR+GEQ + + +++L+IA+AL+ +GVD +E+G P S F ++ IA Q Sbjct: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 N + A +R + +DID ++ + F S + + R TLD +E+ Sbjct: 61 LNVELLAHSRALIEDIDYVLKT----GVDWVGIFFCLSEACLRKRFRITLDHALEKISRA 116 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 ++ A+++ V F+ ED RT A+L R + A I++ DT G T P F ++ Sbjct: 117 IEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVK 176 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245 + ++VH H+DLGLA+ N++ + AGA V+ +NG+GERAG L ++I Sbjct: 177 KIVN-----FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQII 231 Query: 246 MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVL 305 + I ++R S LVS+I + N IVG AF H +G+H VL Sbjct: 232 TVLYYHYGIKKY----RLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVL 287 Query: 306 KNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE 348 K+ YE + E G + + + +G+ +++ +++ G ++ Sbjct: 288 KDPRFYEFLPAEVFGRERT-IYVDRYAGKDTIRYYLEKFGIRD 329 >UniRef50_A9A1L0 Pyruvate carboxyltransferase n=6 Tax=Thaumarchaeota RepID=A9A1L0_NITMS Length = 393 Score = 329 bits (843), Expect = 2e-88, Method: Composition-based stats. Identities = 99/362 (27%), Positives = 182/362 (50%), Gaps = 13/362 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 +++ + D+TLR+GEQ S + K+++QIA L+ GVD +E+ PV S E+ +TI Sbjct: 24 PKKIRVLDSTLREGEQHPGVSFTNKQRIQIAWMLDYFGVDQIEI-SPVVSNDHKEATKTI 82 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 +Q + + + R +++DIDV+ + +A ++ S +H+ KLR + ++ +ER Sbjct: 83 IKQGLKADIVSHGRALKEDIDVSLD----CDAKWCAAYLGISDIHLKDKLRISREDAMER 138 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 A+ V+ A+++ + F+ ED R L +V +A AG I++PDTVG P Sbjct: 139 AVETVEYAKSHGLKIRFTVEDGSRAEPEFLLKVCKAIEEAGVDRISLPDTVGILRPIGMY 198 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 + + + + + H H+D+G AV N+ +A AG Q+ ++GIGER G L Sbjct: 199 NFVKKVRDSI----DVPLDAHVHNDIGFAVANAFSACDAGVDQIHTTIDGIGERTGIPPL 254 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EV +A+ + + S+L+ + + +K IVGS A+ H +G H Sbjct: 255 AEVAVALTY---LYKSPNDFRLDMLLDLSRLIEEYTTIKPYDSKPIVGSSAYKHKAGTHL 311 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 +L+N YE + P ++G N+ ++ +G+ + M +G + + + + Sbjct: 312 AAILRNPAAYEPIPPRAVG-NRRRIVFGELAGKTGAAYLMSLLGLDKDDESAKAVAAGLK 370 Query: 362 KL 363 L Sbjct: 371 GL 372 >UniRef50_C6HVD7 2-isopropylmalate synthase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HVD7_9BACT Length = 392 Score = 328 bits (842), Expect = 2e-88, Method: Composition-based stats. Identities = 115/359 (32%), Positives = 173/359 (48%), Gaps = 12/359 (3%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 + DTTLRDG Q+ K+ + L R+GV +EVG P + E ++ + Sbjct: 13 VFVDTTLRDGGQSPGVFFDRPTKMAVVTTLSRIGVKEIEVGSPCLGEREHEDLKVLLSLP 72 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 + + R VE+D D A R+H TS +H+A R +E ++R Sbjct: 73 VPAEIFPWLRPVEEDFDAALR----LGFRRVHISFPTSDLHMAVLRRVGREETLDRVRRA 128 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 V R V EDA R + L +++ +AG + DTVG P E + IS Sbjct: 129 VCRMVEEGCRVSVGLEDASRAEMGFLRDIIKTVQDAGGIRVRYCDTVGRHHPLEMSERIS 188 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245 L I VH H+DLGLA N++AA HAGA + + G+GERAGN ++EEV Sbjct: 189 ALASC-----GLPIEVHCHNDLGLATANTVAAFHAGAAFLSTTVTGVGERAGNAAMEEVA 243 Query: 246 MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVL 305 A+ + T I+ + S+ + + + IVGS F HSSGIH DGV+ Sbjct: 244 FALAFSGE--GGETGIDFPGLAHISRWLYTAIGRTLSPFRPIVGSRIFHHSSGIHVDGVI 301 Query: 306 KNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 K NYE+ PE +GL + ++ +T ++GRA +K+ ++ MGY+ + LD L + Sbjct: 302 KEPSNYELFPPELVGLKR-KIIVTHQTGRAGIKNVLERMGYRPTSEVLDRLVPVIREEG 359 >UniRef50_A7IBL6 Homocitrate synthase n=19 Tax=Proteobacteria RepID=A7IBL6_XANP2 Length = 415 Score = 328 bits (840), Expect = 4e-88, Method: Composition-based stats. Identities = 125/386 (32%), Positives = 180/386 (46%), Gaps = 12/386 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 ++ + DTTLRDGEQA + + +EK++IA AL GV +E G P + E++++I Sbjct: 30 ARTAFLNDTTLRDGEQAPGVAFTRREKIEIAEALAAAGVPEIEAGTPAMGDEEIETLRSI 89 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 RV A R E+D+ A A ++ I TS + KL D + Sbjct: 90 VSLKLPLRVAAWCRMSEEDLFAAV----SAGVTYVNLSIPTSDRQLKGKLNRDRDWALGA 145 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 ++V A CEDA R L +V E A AGA + + DT+G PF Sbjct: 146 LRHVVTLATKLGFTAAVGCEDASRADPDFLCKVAEVAKEAGAFRLRLADTLGVLDPFSAY 205 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 ++ RV N I H HDDLGLA N+LAAV GAR + G+GERAGN +L Sbjct: 206 ALVR----RVANATDLEIEFHAHDDLGLATANTLAAVTGGARHASVTVAGLGERAGNAAL 261 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EEV +A++ T I+ + +Q V + P+P KAIVG F H SGIH Sbjct: 262 EEVAIALR---QTARSETGIDPHALRPLAQKVMEAAGRPMPRTKAIVGEDIFTHESGIHV 318 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 G+LK+R YE ++PE +G + ++ L SG AA+ + + G E + Sbjct: 319 SGLLKDRGTYEALSPEMLGRSH-RVVLGKHSGLAAILKALSDQGLAVDEARGRAILARVR 377 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEE 387 A + D+ + EE Sbjct: 378 DFAIRSKNSVSPDVLRRFYEDSFTEE 403 >UniRef50_D2LHQ1 Homocitrate synthase n=1 Tax=Rhodomicrobium vannielii ATCC 17100 RepID=D2LHQ1_RHOVA Length = 427 Score = 326 bits (837), Expect = 1e-87, Method: Composition-based stats. Identities = 123/368 (33%), Positives = 180/368 (48%), Gaps = 12/368 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +S +V I DTTLRDGEQ + + EK+QIA AL +GVD +EVG P + E+++ Sbjct: 30 LSGRVAINDTTLRDGEQTPGVAFTAAEKMQIAAALADVGVDEIEVGTPAMGRDEQEAIRR 89 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 IA+ RV A R D+D A + ++ S IA K +L V+ Sbjct: 90 IAKAGLPLRVIAWCRMRRGDVDDAI----ASGVSIVNLSAPVSRFQIAAKFGGSLPRVVA 145 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 ++ AR +V F ED+ R L ++EAA AGA DT+G P Sbjct: 146 AVTDVIGYARAKGLEVAFGGEDSSRATRDTLEPILEAAARAGAVRYRFADTLGVLDPISI 205 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 I + I I H HDDLGLA N+LAA+ AGA +NG+GERAGN Sbjct: 206 RAAIEAVRR----ITDLPIEFHGHDDLGLATANTLAALEAGASAASVTVNGLGERAGNAP 261 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LE++ +A+ + T I+ + S+LV++ I + IVG F H SGIH Sbjct: 262 LEQIAVALD---SLFAQATRIHLPALGHLSELVARCSGREIARSAPIVGKDVFTHESGIH 318 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 DG+LK+++ YE ++P +G N + + SG A ++H + +G + +E L A Sbjct: 319 VDGILKSKDCYEALSPRRLGRNH-RFVVGKHSGLAGLRHELSYLGLQLTEDEERRLLAAV 377 Query: 361 LKLADKKG 368 A+K Sbjct: 378 RGYAEKHK 385 >UniRef50_B6YRB4 Homocitrate synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YRB4_AZOPC Length = 374 Score = 325 bits (834), Expect = 2e-87, Method: Composition-based stats. Identities = 99/370 (26%), Positives = 169/370 (45%), Gaps = 12/370 (3%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 + D+TLRDGEQA KEK+++A L +G+D +EVG P + ++Q I R Sbjct: 6 FLIDSTLRDGEQAPNVVFLRKEKIRLAQMLSEIGIDEIEVGIPAMGEDECNTIQNIVRLK 65 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 + +R ++KDI+ A A IH S + + + T V + Sbjct: 66 LRPIISVWSRAIKKDIEQA----STLGATCIHIAFPLSDIQLQA-INKTYGWVEDTFSKT 120 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 ++ A+N + V +DA R PI + + ++ A G + DTVG P + II Sbjct: 121 IQCAKNLFERVSVGAQDASRCPIDRVIQFIDMAEKYGVFRVRFADTVGILTPIQTIEIIR 180 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245 + ++ N++ I H H+D G+A N+L A GA + +NG+GERAGN +LEE++ Sbjct: 181 TIKKKKTNMN---IDFHAHNDFGMATANALTAYQVGANSLSVTINGLGERAGNAALEEIL 237 Query: 246 MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVL 305 M ++ T + ++ + VS I P+P KAI G A +H SGIH +L Sbjct: 238 MGLRQING----KTKYDLSTLFDLCRYVSVISGRPLPDGKAICGKFAVSHESGIHTQAIL 293 Query: 306 KNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLAD 365 + ++ + +G + + SG+ A+ + + E + L + A+ Sbjct: 294 SDILAFQPFNGDILGREKCSILFGKHSGKRAIIDLLKRQNIEVEESRISLLIEKIRNTAN 353 Query: 366 KKGQVFDYDL 375 + + Sbjct: 354 VIRRSLSSEE 363 >UniRef50_Q52070 Homocitrate synthase n=9 Tax=Gammaproteobacteria RepID=NIFV_ENTAG Length = 400 Score = 325 bits (834), Expect = 2e-87, Method: Composition-based stats. Identities = 112/391 (28%), Positives = 175/391 (44%), Gaps = 13/391 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 VII DTTLRDGEQ+ + EKL+IA AL GV +E G P + + + RQ Sbjct: 18 VIINDTTLRDGEQSPGVAFRASEKLEIAQALVNAGVRELEAGTPALGEEECVRLAILRRQ 77 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 + ++ + + R +I +A + + S + KL VI Sbjct: 78 LPDTVMMSWCRMNSAEIHDSAR----VGMDWVDISVPASDLLREQKLHRPWPAVIASLKP 133 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 +V+ A V CEDA R+ L + E A + G + DT+G PF I Sbjct: 134 LVQLAHRLGMRVCMGCEDASRSADETLHMLAEVAADLGIERMRFADTLGILDPFSTFTRI 193 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 S L + + +H H+DLG+A N+LAAV AGA V + G+GERAGN +LE V Sbjct: 194 SALRQHWHG----GLEIHAHNDLGMATANTLAAVRAGATHVNTTVLGLGERAGNAALESV 249 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 +++ L++ I+ E+ +LV+ I +VG F H SG+H + Sbjct: 250 TLSLD---RCLHLDCGIDFTELPALCRLVAAAAGRTIDVQHPLVGGQVFTHESGLHVAAL 306 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 L++ +Y+ + P +G + L L SGR AV +GY SE + + A Sbjct: 307 LRDPRSYQGIDPSLVGR-EFNLVLGKHSGRQAVSGICARLGYILSETQTLLMLQEVKRFA 365 Query: 365 DK-KGQVFDYDLEALAFIGKQQEEPEHFRLD 394 + K + ++ A+ + + P +L Sbjct: 366 EHFKRNPGEDEVIAMCQMRMDDQIPFEGQLQ 396 >UniRef50_Q12122 Homocitrate synthase, mitochondrial n=109 Tax=cellular organisms RepID=HOSM_YEAST Length = 440 Score = 324 bits (831), Expect = 5e-87, Method: Composition-based stats. Identities = 98/363 (26%), Positives = 166/363 (45%), Gaps = 9/363 (2%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + + D+TLR+GEQ A ++K++IA AL+ GVD +E+ PV+S + + I Sbjct: 35 KNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAIC 94 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 + +++ RC D VA E+ + I TS ++ + + A Sbjct: 95 KLGLKAKILTHIRCHMDDARVAVET----GVDGVDVVIGTSKFLRQYSHGKDMNYIAKSA 150 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + +++ ++ ++ FS ED+ R+ + DL + + G + I DTVG P + Sbjct: 151 VEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYE 210 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 +I L V I H H+D G A+ N+ A+ GAR ++ ++ GIGER G L Sbjct: 211 LIRTLKSVV----SCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLG 266 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 + MA + V + +I LV+ + IP N I G AF H +GIH Sbjct: 267 GL-MARMIVAAPDYVRSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAK 325 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 +L N YEI+ P G+ + +G A+K R+D++ ++ + + K Sbjct: 326 AILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKSRVDQLNLNLTDDQIKEVTAKIKK 385 Query: 363 LAD 365 L D Sbjct: 386 LGD 388 >UniRef50_C5QA64 2-isopropylmalate synthase n=1 Tax=Staphylococcus epidermidis BCM-HMP0060 RepID=C5QA64_STAEP Length = 390 Score = 321 bits (824), Expect = 3e-86, Method: Composition-based stats. Identities = 113/367 (30%), Positives = 195/367 (53%), Gaps = 5/367 (1%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ DTTLRDGEQA SL EKL++AL LE+ G++ +E GFP SS DF S Q I+ Sbjct: 6 RKITFLDTTLRDGEQAPGNSLKHGEKLELALMLEKAGIETIETGFPASSKEDFISTQKIS 65 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 + +K S +R +DID++ ++ +E + S +H+ K + + + IE Sbjct: 66 KILKTSNFATFSRTKLEDIDLSIQAGGTSEKHILMLVATGSDLHLEKKRKMSRQDGIEEI 125 Query: 123 IYMVKRARNYTD-DVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 V AR +V EDA R + ++ A+ +GA I + DT GY MP + Sbjct: 126 KKSVVYAREKGIKNVAVGIEDASRADSKYVEELINVAVQSGANQIILADTTGYAMPNDIY 185 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 ++ + +SVH H+DLGLAV NS A+ AGA +++G + GIGERAGN S+ Sbjct: 186 DLVKLSKRCISK--SIKLSVHCHNDLGLAVINSYYAILAGADEIQGTIGGIGERAGNTSI 243 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 E+V+ I + +++ +N + ++ + +S+ ++ I G F+ ++GIHQ Sbjct: 244 EQVLALIHYKGKNKKIYSDVNKKNLYPIYEKLSEYIDLEENRTLPIFGKYVFSTAAGIHQ 303 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMG-YKESEYNLDNLYDAF 360 G+L + + YE + PE G + + + SG++ +K +++ + +D+LY+ + Sbjct: 304 QGILNDPKTYEFVLPEDWGRTR-EFYIDKHSGKSILKDVVEKQNATDIVKDKIDSLYNKY 362 Query: 361 LKLADKK 367 + D+ Sbjct: 363 IDNNDRT 369 >UniRef50_C7N750 Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Slackia heliotrinireducens DSM 20476 RepID=C7N750_SLAHD Length = 471 Score = 321 bits (823), Expect = 4e-86, Method: Composition-based stats. Identities = 141/502 (28%), Positives = 240/502 (47%), Gaps = 33/502 (6%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + V + D T+R E + +L+ KEKL+ A L+ +GV +E+ S D +++IA Sbjct: 2 RDVRVSDVTMRQAEVSGSLALTFKEKLETAKLLDSLGVSSIEIEGVERSKADALRIKSIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 VKNS + + +++I V +LK A R+ A SP + D +++ Sbjct: 62 SIVKNSVLAVPVKMDDENIQVVWGALKNAAFPRLQVVAAVSPARMEYVYHKKADGMMKDV 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + + TDDVEF +DA R L V++ AI AGA TI + D G +P EFA Sbjct: 122 AATIAKCAALTDDVEFVADDATRADSVYLRSVIKEAIQAGAKTITVCDDAGTMLPEEFAQ 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I L + +P + + + +DL +A ++A + +G +++ + SLE Sbjct: 182 FIDDLRKDLPELADVALGISCSNDLFMADACAIAGIMSGVDEIKATTYPM----NVISLE 237 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 +V + + +I T + E+ RT+ V++IC Sbjct: 238 KVCKVLAAKPEICQAQTTVRVTELKRTAAQVARICE------------------------ 273 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 + R Y P G ++ LT AV + ++GY+ SE + N+Y+AFL+ Sbjct: 274 ---QGRSKYSAFNPNVTGSDE-SFVLTVNDDIDAVMECVAKLGYELSEEDATNVYEAFLR 329 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEA 422 +A KK V + +L+A+ Q P + L+ + + SG+ ATA V++ G+EV Sbjct: 330 IASKKDSVSNLELDAIVASAALQ-VPATYVLENYVINSGNAIKATANVRMRKGDEVLEAV 388 Query: 423 ANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLAT 482 G+GP+DA + AI +I+ EL + + + G++A+GQ + +G+ + G G++T Sbjct: 389 CIGDGPIDASFLAIEKISGKRYELDDWQMQSVTEGQEAMGQAIVKLVADGKIYSGRGIST 448 Query: 483 DIVESSAKAMVHVLNNIWRAAE 504 DIV SS +A V+ LN I E Sbjct: 449 DIVGSSIRAYVNALNKIVYEEE 470 >UniRef50_Q7M8U7 HOMOCITRATE SYTHASE 1 n=1 Tax=Wolinella succinogenes RepID=Q7M8U7_WOLSU Length = 376 Score = 321 bits (823), Expect = 4e-86, Method: Composition-based stats. Identities = 96/386 (24%), Positives = 165/386 (42%), Gaps = 12/386 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + I DTTLRDGEQA + + +EK +IA L G D +E+G P + E ++ I Sbjct: 2 ITINDTTLRDGEQAPTVAFTQEEKCEIAKLLYEAGADELEIGIPAMGEAEREDIRAILSL 61 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 R+ + R + D++ + + I S +A K R +V+ Sbjct: 62 GLPLRLMSWNRATQSDLEASL----ACGMKAVDLSIPVSTKMVAAKFRGKYAKVLSNLEE 117 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 + A+ V ED R L V+ A+ GA + DTVG P + I Sbjct: 118 TLTIAKKEGLFVCVGMEDTSRANARFLKEVIALAMERGADRVRFCDTVGILTPLQTYRAI 177 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 L + +H H+D G+AV NS+A + AGA+ V + GIGERAGN E+V Sbjct: 178 RSLRRHCT----LPVEMHCHNDYGMAVANSIAGIEAGAQSVNTTVIGIGERAGNAGFEQV 233 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 ++++ + ++ + Q V++ + + +VGS F H SGIH DG Sbjct: 234 LLSLIGQFGQNR---TLDSTILKALVQKVAKAAGVALAPTAPVVGSRLFWHESGIHADGN 290 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 K+ YE +PE +G ++ + + SG A + + + + + +L ++ Sbjct: 291 QKSEGLYEPFSPELVGASR-EYPIGKHSGSANLIYHLKQFVPLIEKGEASDLLPLVREIV 349 Query: 365 DKKGQVFDYDLEALAFIGKQQEEPEH 390 K + ++ ++ + Sbjct: 350 TKNKKPLSAKELFCLYLSHKRHSQKE 375 >UniRef50_B7G5N8 2-isopropylmalate synthase n=2 Tax=Bacillariophyta RepID=B7G5N8_PHATR Length = 581 Score = 320 bits (821), Expect = 8e-86, Method: Composition-based stats. Identities = 131/557 (23%), Positives = 225/557 (40%), Gaps = 77/557 (13%) Query: 13 RDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNS---R 69 RDG Q S SV +KL+I L GVD +E G+P S+P D + ++ + Sbjct: 8 RDGTQGESVSASVDDKLKITRRLVAFGVDFVEAGWPGSNPKDAAFFTRAKTDLTHAERDK 67 Query: 70 VCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 + A K + D ++L ++A + + LR+TLDE ++ Sbjct: 68 LVAFGSTRRKRVRANEDPQVQALLESQAPTVCIVAKAHAWQVTEILRATLDENLDMIRDT 127 Query: 126 VKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 V + V E D T + AA++ GA+ + DT G TMP+ Sbjct: 128 VACLVAHGRVVMVDLEHALDGYATDPDYVHACCRAAVDGGASVLVACDTNGGTMPWRVGT 187 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 ++ L + I +H H+D G+AV NSL A GA ++G +NGIGER GN L Sbjct: 188 VVRELVDTY-GPQGVTIGMHAHNDCGMAVANSLTAAQYGAGLIQGTVNGIGERTGNADLC 246 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 ++ ++ + +H + + S+ V ++ N VGS AFAH G+H Sbjct: 247 AIVPSLALHVQ-AQLHCRASLATLTSLSRFVDEVLNQTPNHAAPFVGSSAFAHKGGLHVA 305 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE----SEYNLDNL-- 356 + ++ +Y+ + PE +G N+ ++ ++ SGR + +M + G S+ + L Sbjct: 306 AMERSPLSYQHIEPELVG-NEQRILISELSGRQNILGKMQQAGVDLGTSGSDRAVAILNR 364 Query: 357 ----------------------------YDAFLKLADKKGQVFDYDLEALAFIGKQQEEP 388 Y ++ D QV+D ++++ + + E P Sbjct: 365 VKTLEAQGYTFEGAEASVHLMILHATKGYCPPFQVLDYSAQVYDANIDSATRVLRHTESP 424 Query: 389 EHFRLDYFSVQS--GSNDIATAAVKLACGEEVKA----------------EAANGNGPVD 430 + D + G A A V + ++ E ++GNGPVD Sbjct: 425 DTDPTDSKKPRKAPGFGPTARATVNVRTMRPIEDGLESYLANLSPYQDRLEVSDGNGPVD 484 Query: 431 AVYQAINRITE------YNVELVKYSLTAKGH--GKDALGQVDIVANYNG----RRFHGV 478 A+ A+ R + +VELV Y + A +V I N + V Sbjct: 485 ALANALMRALQPVHPILQHVELVDYKVRILDAENATGATTRVMIEFRNNSDGDQETWTTV 544 Query: 479 GLATDIVESSAKAMVHV 495 + T+++ +S A+V Sbjct: 545 SVDTNVISASLNALVDG 561 >UniRef50_B5JMT2 HMGL-like domain protein n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JMT2_9BACT Length = 372 Score = 319 bits (817), Expect = 2e-85, Method: Composition-based stats. Identities = 110/377 (29%), Positives = 180/377 (47%), Gaps = 13/377 (3%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 + DTTLRDGEQA + S+ EK IA L + G+ +EVG P + + ++ I++ Sbjct: 7 YLIDTTLRDGEQAAGVAFSLSEKKAIATLLSQTGIPEIEVGIPAMGECERQHIRAISQLD 66 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 + R+ R V +D+ A++S A H + SP+H+ + V+ + Sbjct: 67 LDCRILTWGRAVREDLRAASKS----GADGFHFSLPASPLHLRI-WKKNERWVLRTMSEL 121 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 K A + + +DA R L ++AA GA+ + I DT G P + + Sbjct: 122 AKEAADTFEYFSVGAQDASRADRDFLKLFIDAAQVLGASRVRIADTTGRLNPIDTLDLFC 181 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245 + + + H H+DLG+AV N+++A GA +NG+GERAGN +LEEV Sbjct: 182 DITKNA----SIDLEFHAHNDLGMAVANTVSAFIGGATCASVTVNGLGERAGNAALEEVS 237 Query: 246 MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVL 305 MA+K DI ++ ++ S V+ + NK + G GA +H SGIH G+L Sbjct: 238 MALKHSTDI---DIPMDASHYYKLSDYVANASQRRLAWNKPVTGPGAHSHESGIHCKGLL 294 Query: 306 KNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLAD 365 + +YE ++PE IG ++ + + SG AAV ++G+ S L A+ Sbjct: 295 TDSRSYETVSPEEIGQSRPEFAIGRHSGSAAVIAAAQKLGHTLSAKKATALLPLIRTAAE 354 Query: 366 KKGQVFDY-DLEALAFI 381 ++G+ +L L I Sbjct: 355 QRGRSLTASELSRLIEI 371 >UniRef50_C0W2B6 Alpha-isopropylmalate/homocitrate synthase family transferase n=1 Tax=Actinomyces urogenitalis DSM 15434 RepID=C0W2B6_9ACTO Length = 551 Score = 318 bits (814), Expect = 4e-85, Method: Composition-based stats. Identities = 138/537 (25%), Positives = 235/537 (43%), Gaps = 43/537 (8%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 ++ +V +DTTLRDG Q S +V++KL +A L+ +GV +E G+P + P D E Sbjct: 3 LTPRVATYDTTLRDGAQQQSVSFTVEDKLAVARILDHLGVTYIEAGWPGAIPKDTEFFAR 62 Query: 61 IARQVK--NSRVCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRST 114 A ++ +R+ A D L + A I + P H+ LR++ Sbjct: 63 AASELSLATARLVAFGSTCHPGTAAEKDPQLRGLLDSGAPVITIVAKSDPAHVERALRTS 122 Query: 115 LDEVIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDT 171 +E + V +V E D + A AGA+ + DT Sbjct: 123 GEENLRMVADSVGLLVAAGREVMVDLEHYVDGVARDPRYGIELALTAARAGASAVIPCDT 182 Query: 172 VGYTMPFEFAGIISGLYERV--PNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 G ++P A IS L + + ++ +HTHDD GLAV ++AAV AGARQV+G + Sbjct: 183 NGGSLPGTVAAEISRLRAALDAAGHEDCVVGIHTHDDSGLAVAAAMAAVEAGARQVQGCV 242 Query: 230 NGIGERAGNCSLEEVIMAIKVRKDIL-----NVHTAINHQEIWRTSQLVSQICNMPIPAN 284 NG GER GN +L +I ++++ + A E+ S+ V +I N Sbjct: 243 NGFGERTGNANLLTLIANLELKTGYQALAGDSQERARRLAELSAVSRTVGEIANRAPSGR 302 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEM 344 VGS AFAH +G+H + + Y+ + P +G N + + ++ +GRA+++ + E+ Sbjct: 303 LPYVGSKAFAHKAGLHASAIKVDPNLYQHVDPARVG-NTMTMLVSEMAGRASIELKAREL 361 Query: 345 GYKE-SEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQ--EEPEHFRLDYFSVQ-- 399 G + + L +K + G +D + + +Q + P++FR++ + Sbjct: 362 GIETGGDKELLARVTEVVKGREAAGYAYDAADGSFELLLRQALGQLPQYFRVESWRASVT 421 Query: 400 ----SGSNDIA---------TAAVKLACGEEVKAEAANGNGPVDAVYQAINRITE----- 441 +G + A V++ G A GNGPV+A+ A+ Sbjct: 422 ARPAAGQEILPEDGATVTDSEATVRMWVGGRRLAVLGEGNGPVNALDHALCDALATAYPE 481 Query: 442 -YNVELVKYSLTAKGH--GKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHV 495 EL + + G A+ +V I R + VG+ TDI+E+S +A+ Sbjct: 482 IRAFELTDFKVRILDSERGTHAIVRVLIDITDGERSWSTVGVGTDIIEASWEALTDG 538 >UniRef50_C1FHL1 2-isopropylmalate synthase n=2 Tax=cellular organisms RepID=C1FHL1_9CHLO Length = 662 Score = 313 bits (802), Expect = 1e-83, Method: Composition-based stats. Identities = 125/573 (21%), Positives = 219/573 (38%), Gaps = 84/573 (14%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 V+ +DTTLRDG Q + SL+ +KL +A L +GV +E G+P S+P D E Sbjct: 63 DVVCYDTTLRDGSQQVGISLTCDDKLAVAEHLVGLGVAYIEGGYPGSNPKDVEFFSRWTS 122 Query: 64 QVK-------NSRVCALARCVEK----DIDVAAESLKVAEAFRIHTFIATSPMHIATKLR 112 +++ A + D D ++L A + L Sbjct: 123 SGLADRAAAGGTKLAAFGMTRRRGVTADDDEGLKALTDCPAPCVCIVAKAWDEQCEKVLG 182 Query: 113 STLDEVIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIP 169 + +E I V +V CE D + + AA +GA + + Sbjct: 183 VSPEENIAMIEESVAHLVAAGKEVLVDCEHYFDGRKANPEFAVKCAAAAAKSGAKFVVLC 242 Query: 170 DTVGYTMPFEFAGIISGLYERVPNID-KAIISVHTHDDLGLAVGNSLAAVHAGARQVEGA 228 DT G T+P++ + E V + +H H+D LAV NS+AAV GA V+G Sbjct: 243 DTNGGTLPWDVEEFTREVKEAVDATGADCSVGIHCHNDTSLAVANSIAAVRGGATMVQGC 302 Query: 229 MNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIV 288 +NG GER GN L V ++++ + + Q + + S V+++C+ + + Sbjct: 303 VNGYGERTGNADLLVVAANLELKMGRTALPEG-SLQRLTQVSAAVAKLCSQHQDPRQPYM 361 Query: 289 GSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE 348 GS AFAH G+H + K +Y + P +G N+ + ++ SGR + G + Sbjct: 362 GSSAFAHKGGLHVAALQKMPASYNHIVPTLVG-NEARSVISELSGRGNILSAAMASGREV 420 Query: 349 SEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEH---FRLDYFSVQSGSNDI 405 S+ + L + +G V + D A I ++ +P + F + F+V + ++ Sbjct: 421 SKETAAQVLSQIKDL-ESRGFVLE-DAGASVDILFRRADPNYRAPFNVLEFNVTASNSSF 478 Query: 406 ATAAVK-LACGEEVKAE------------------------------------------- 421 L G + + + Sbjct: 479 GGFTPNDLLVGGDERLQDVLPEDELEAPFTHPQQAGYKKGSVAVNQVVVKVDVFDNDTTP 538 Query: 422 --------AANGNGPVDAVYQAIN-RITE-----YNVELVKYSLTAKGHGKDALGQVDIV 467 A GNGPV+A+ A+ +T+ + L Y + + + Sbjct: 539 ASRNTQLCVAEGNGPVNALANALRLSLTDKFPQLKQIHLQDYKVDLLSTAGTSAAVTRVT 598 Query: 468 ANYNGR----RFHGVGLATDIVESSAKAMVHVL 496 ++ R + VG I+E+S +A+V + Sbjct: 599 MDFADRDTDITWRTVGAHASIIEASFRALVDGM 631 >UniRef50_Q01181 Homocitrate synthase n=27 Tax=Proteobacteria RepID=NIFV_RHOSH Length = 391 Score = 311 bits (798), Expect = 3e-83, Method: Composition-based stats. Identities = 114/377 (30%), Positives = 167/377 (44%), Gaps = 16/377 (4%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V + DTTLRDGEQ + + EK IA AL+ GV +EVG P + ++ +A Sbjct: 19 VALCDTTLRDGEQTAGVAFTRAEKRAIAEALQAAGVAEVEVGVPAMGEEERADIRAVAAV 78 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 +K + R +D+ A + R+H + S I+ KL V ++ Sbjct: 79 LKTAAPVVWCRLRAEDLAAAQRT----GVVRLHIGVPVSERQISAKLGKDAAWVRDKVEK 134 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 +V+ A V EDA R LA + A AGA I DT+G PF ++ Sbjct: 135 LVRAASWAGHKVSVGAEDASRADPFFLAEIAHVAAEAGAIRFRISDTLGVLDPFAAHELV 194 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + R P + H H+DLG+A NSLAA AGA + +NG+GERAGN + Sbjct: 195 GRVVTRCP----LPVEFHGHNDLGMATANSLAAARAGASHLSVTVNGLGERAGNAA---- 246 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 + + + T + ++ S+LV++ P+ K IVG G F H GIH DG+ Sbjct: 247 LEEVAAALEAAGRATGVALGQLCALSELVARASGRPLSPQKPIVGEGVFTHECGIHVDGL 306 Query: 305 LKNRENYE--IMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 +K+R YE + PE G + ++ + S A + + E G L L A Sbjct: 307 MKDRATYESADLRPERFGRSH-RIAIGKHSSAAGLARALAEAGLPADAATLAALMPALRD 365 Query: 363 LAD-KKGQVFDYDLEAL 378 A K DL AL Sbjct: 366 WAAITKRAAAPEDLAAL 382 >UniRef50_A8F3U8 2-isopropylmalate synthase n=1 Tax=Thermotoga lettingae TMO RepID=A8F3U8_THELT Length = 415 Score = 311 bits (797), Expect = 4e-83, Method: Composition-based stats. Identities = 124/391 (31%), Positives = 192/391 (49%), Gaps = 20/391 (5%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + +QVII D TLRDGEQ + EK+ IA L+++GV ++EVGFP S D + Sbjct: 34 LPEQVIIHDVTLRDGEQMAGVVFTEDEKVFIAQELDKIGVPMIEVGFPAVSGEDQRVFKR 93 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 +++ ++ ALAR +++D+ +AAE A + + +P + L E I+ Sbjct: 94 LSKMNLKAKKIALARIMDEDVKLAAE----CGADGLFYETSINPYFVKYVLGLDSKEFID 149 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVV--EAAINAGATTINIPDTVGYTMPF 178 R I K A+ VEF D R + + V E N I I DT G PF Sbjct: 150 RIIKGAKLAKELGLFVEFCGWDTFRINNLEWIKTVYTELLKNVEVDQIGISDTFGQAHPF 209 Query: 179 EFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGN 238 ++ + E P+I +S+H H+D GLA +L A+ +GA VE + N +GER GN Sbjct: 210 TVNFLVRKMKEWFPSIP---LSIHVHNDYGLATATALMAIASGAEAVETSFNCLGERTGN 266 Query: 239 CSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSG 298 S EEVI I++ IL + T ++ QE++R S+++ ++ M + NK IVG F SG Sbjct: 267 ASTEEVIAGIEM---ILGIKTNVDCQELYRVSKMIQEVSKMHVAPNKPIVGDRIFDSESG 323 Query: 299 IHQDGVLKNRENYE------IMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYN 352 I D K E PE+ G ++ +SGRA VK +D+ G K +E Sbjct: 324 IVIDANEKINRATEIKYAMYPYNPENFGR-WLKYVGGKKSGRAFVKQYLDKRGLKANEAQ 382 Query: 353 LDNLYDAFLKLAD-KKGQVFDYDLEALAFIG 382 +D + K+ K + D D++ + + Sbjct: 383 IDEILVRIKKIGTVLKSALSDEDIDRIVELV 413 >UniRef50_D0LNR8 Pyruvate carboxyltransferase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNR8_HALO1 Length = 429 Score = 308 bits (789), Expect = 4e-82, Method: Composition-based stats. Identities = 108/366 (29%), Positives = 170/366 (46%), Gaps = 11/366 (3%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + V I D TLRDGEQA L+V+EKL +A L + GVDV++ GFP SSP D E++Q + Sbjct: 12 KPVEIIDCTLRDGEQAPGVWLTVQEKLALAKLLSQAGVDVLDAGFPASSPADMEAMQEMV 71 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 +R+ A AR + +DI A ++A A + F+ TS + + L T D+ I Sbjct: 72 AAGLRARIAATARPLARDIVAA----EMANAHEVFMFLPTSALRMEQTLGITRDQAISLF 127 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAA-INAGATTINIPDTVGYTMPFEFA 181 + + + EDA R+ L +V A + + DTVG +P Sbjct: 128 CSGAEEVCSRGMTLNLVFEDATRSRPEMLTEIVRQVHAQADVRRVILADTVGCAIPAAME 187 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 + + + +++ H H+D GLAV N+LAAV GA V +NGIGERAGN L Sbjct: 188 ALTRTVRSEIDA--DIVVTPHCHNDFGLAVANTLAAVSGGAGAVTCTVNGIGERAGNADL 245 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 E + + + +L ++ ++ + V + K + G F H SGIH Sbjct: 246 AETVAGLSL---LLQREHGVDPHQLVALQEAVEIATGIHQSPTKPVTGINVFRHESGIHV 302 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 DG+LK+ +YE + +G + + L SG + ++ G E+ L Sbjct: 303 DGMLKDPRSYEFLPASWVGR-RSEYILGKHSGTSLIRRLAHMAGLDCDEHTASLLLAEVK 361 Query: 362 KLADKK 367 ++ Sbjct: 362 AATQQR 367 >UniRef50_A9VAW1 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VAW1_MONBE Length = 564 Score = 308 bits (788), Expect = 5e-82, Method: Composition-based stats. Identities = 99/403 (24%), Positives = 173/403 (42%), Gaps = 7/403 (1%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I DTTLR+GEQ + +++ IA L+ GVD +E+ P +S E + IA Sbjct: 40 IIDTTLREGEQFSSTDFTSHDRVYIAKLLDTFGVDYIELVNPFASHQAREDCRAIANLGL 99 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 +++ A RC D+ E+ + ++ATS ++ VI+ A ++ Sbjct: 100 KAKIVAHTRCHMDDVRACVET----GIDGVSMYMATSEALRRHSHGKSVQAVIDSAREVI 155 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 + ++ +V FSCED R+ +L + A G + + DTVG PF+ A ++ Sbjct: 156 EFVKDNGMEVRFSCEDTFRSDRTELLDIYAAIDELGVNRVGLADTVGIATPFQVAETVAA 215 Query: 187 LYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIM 246 + + + I HTH+D G + N+L A+ AGA + + G+GER G L + Sbjct: 216 VRSIIK--PETGIEFHTHNDTGCCIANALVALQAGATHINTCVLGVGERNGITPLGGF-L 272 Query: 247 AIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLK 306 A D +V + + + + V+ + IP N I GS AF H +G+H V+ Sbjct: 273 ARMYTLDRESVKNKYDLKLLRHLEKYVAAAAKVQIPFNNYITGSSAFTHKAGVHSKAVMS 332 Query: 307 NRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADK 366 + YE++ P+ G+ + +G A+K R ++ + + A Sbjct: 333 DPGAYEVINPDDFGVGRNIEIAHHLTGWNALKARSMDLNLTIPDDQIKAATKMVKHYAAD 392 Query: 367 KGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAA 409 KG + L IG+ + + ++ TA Sbjct: 393 KGIKPSQLDQLLIGIGRVAASNSSSDFVKMAALQPTPELKTAM 435 >UniRef50_A3JSY7 Putative uncharacterized protein n=2 Tax=Bacteria RepID=A3JSY7_9RHOB Length = 403 Score = 307 bits (786), Expect = 8e-82, Method: Composition-based stats. Identities = 100/375 (26%), Positives = 179/375 (47%), Gaps = 14/375 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + +V I D TLRDGEQ S+ +K+ IA L+ +GVD +E G P SP D ++ Sbjct: 28 LPAKVEIHDATLRDGEQTPGVVFSIDDKIAIASKLDELGVDRIEAGMPAVSPQDATAITE 87 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I++ S++ AR ++ DID+A + A + + + T+ T ++V++ Sbjct: 88 ISKLGLKSKIYTFARAMKADIDMALQ----CGADGVIIEVPIGYPKLKTQFGWTWEDVVK 143 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAIN-AGATTINIPDTVGYTMPFE 179 ++ ++ A+ F D R +DL + +A ++ + I + DT+G P Sbjct: 144 KSAPVINYAKENGLHAVFFPYDTTRARRSDLENMCKAIMDQSPPDAIGLVDTMGCATPEA 203 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 ++ L + + + + +HTH+D G+ V LAAV AGA+ V NG+GER GN Sbjct: 204 IKYMVRWLTK----MTELPVEIHTHNDFGMGVATELAAVTAGAQCVHSCANGLGERTGNA 259 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 +LEE++M + + T +I L+++ N+ I NK ++G G F SGI Sbjct: 260 ALEELMMGLHLLYG---YDTQYKLGKIPELGALIAERSNISIARNKPVLGHGNFIRESGI 316 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGY-KESEYNLDNLYD 358 D V+ + T S+ ++ L +SG+A++ ++M E+G + + + + Sbjct: 317 GIDYVMNDP-LVMFGTHPSLTGKVGEVVLGKKSGKASIIYKMGELGMGVLEDDKIAMILE 375 Query: 359 AFLKLADKKGQVFDY 373 K V + Sbjct: 376 EVKNAGIAKRDVLSH 390 >UniRef50_Q07179 Homocitrate synthase n=3 Tax=Rhodobacter RepID=NIFV_RHOCA Length = 382 Score = 307 bits (786), Expect = 9e-82, Method: Composition-based stats. Identities = 113/381 (29%), Positives = 176/381 (46%), Gaps = 17/381 (4%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + + + DTTLRDGEQ + S+ EK IA AL+R GV +EVG + ++ + Sbjct: 5 RTLALCDTTLRDGEQTAGVAFSLAEKKAIARALDRAGVAEIEVGIAAMGWAEVAEIRAVV 64 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 ++ ++ R D+D+A ++ R+H + TS + KLR D ++ Sbjct: 65 AEIAHATPVVWCRLRMHDLDMAQKT----GVKRVHFAVPTSTAQLEGKLRVDRDWILRET 120 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 +V A + V EDA RT L R+ E A AGA I DT+G P Sbjct: 121 AALVFCASDRGLQVSVGAEDASRTDPDFLIRLAEVAAAAGAIRFRIADTLGLLDPLGAFR 180 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 +++ L R+ I +H H+D G+A N++ A HAGA + +NG+GERAGN + E Sbjct: 181 LVAELSARI----SLPIEMHAHNDFGMATANTIMAAHAGATHLSVTVNGLGERAGNAACE 236 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSG-AFAHSSGIHQ 301 EV A++ + T ++ + S +V++ A K I G FAH SGIH Sbjct: 237 EVGAALEA----GGIDTGLDLCALPELSAVVAKASGRAFRAQKPITGDDWLFAHESGIHV 292 Query: 302 DGVLKNRENYE--IMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 D +LK + YE P G + Q+ + SG A ++ + E G + LD L Sbjct: 293 DAILKRADTYEDPRCAPARFGRER-QIVIGKHSGSAGLRAALLEAGLPADDAVLDRLKPL 351 Query: 360 FLKLADKKGQVFDY-DLEALA 379 A + + + DL + Sbjct: 352 LRAHAVRVKRPVEAGDLRRMV 372 >UniRef50_C1AUX2 2-isopropylmalate synthase n=8 Tax=Bacteria RepID=C1AUX2_RHOOB Length = 570 Score = 306 bits (784), Expect = 1e-81, Method: Composition-based stats. Identities = 110/526 (20%), Positives = 196/526 (37%), Gaps = 45/526 (8%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ- 64 + LRDG QAL + + K + L +G +EVG+P +S DF+ V+ + R Sbjct: 44 LWVPVDLRDGNQALAEPMDPERKRRFFELLISIGYKEIEVGYPSASQTDFDFVRDLVRLD 103 Query: 65 --VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE----V 118 + + + I ES++ +H + AT+P + L + Sbjct: 104 LVPDDVTIVVFTAARDDLIARTYESVEGLPNVVVHMYTATAPTWRSVVLGKDRKALHRLI 163 Query: 119 IERAIYMVKRARNY-TDDVEFSCEDAGRTPIADLARVVE---AAINAGATT---INIPDT 171 + A + + A + EFS E T V +A N+P T Sbjct: 164 FDAAQEVARGAGDRPGLRFEFSPEVFNLTEPDFALEVCNSLTRLWDASPDRPVIHNLPAT 223 Query: 172 VGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNG 231 V + P +A I ++ + + + I+SVH H+D G V + AV AGA++VEG + G Sbjct: 224 VEVSTPNVYADQIEYMHRHLEDRESVILSVHPHNDRGTGVACAELAVLAGAQRVEGCLFG 283 Query: 232 IGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSG 291 GER GN L + + + + V I+ +I + V +P+ G Sbjct: 284 NGERTGNVDLVTLALNLHAQG----VDPMIDLSDIDAVRRTVEYCNRIPVHERHPYGGDL 339 Query: 292 AFAHSSGIHQDGVLKNRENYE--------------------IMTPESIGLN-QIQLNLTS 330 + SG HQD + K + + P +G + Q + + S Sbjct: 340 VYTAFSGTHQDAIKKGFAEHRASAEAAGLDPGSAPWAVPYLPIDPADVGRDYQAVIRINS 399 Query: 331 RSGRAAVKHRMD-EMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPE 389 +SG+ + H + E G + + AD G + F E Sbjct: 400 QSGKGGIAHLLQSEYGITLPRRLQIDFAAKVQEAADSSGLEITAEELWTLF---CAEYGY 456 Query: 390 HFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKY 449 L +SV+ G + V + A GPV+A+ + + +V+++ Sbjct: 457 RGGLGRWSVEHGPDGDRLFVV-FDVDGAEASGEAVAAGPVEAMTRVLTS-KGVDVDVLSL 514 Query: 450 SLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHV 495 + ++ G D+ + R G+G + S+ +A+ Sbjct: 515 TQHSQRSGSDSAAITLAECSVGERTVWGMGSHQSVTASAIRAVYAA 560 >UniRef50_B0TW82 2-isopropylmalate synthase n=17 Tax=Francisella RepID=B0TW82_FRAP2 Length = 526 Score = 303 bits (777), Expect = 9e-81, Method: Composition-based stats. Identities = 133/523 (25%), Positives = 235/523 (44%), Gaps = 32/523 (6%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ IFDTTLRDG+Q+ A +S ++ + A ++ +DV+E GFP +S DFE V TI+ Sbjct: 4 KKIYIFDTTLRDGQQSPGAGMSFEDNIAYADLANKLNIDVLEAGFPSASNTDFEIVNTIS 63 Query: 63 RQV----KNSRVCALARCVEKDIDVAAESLKVA---EAFRIHTFIATSPMHIATKL--RS 113 +++ N + L + + +++ ++L+ + R+H ++ P L ++ Sbjct: 64 KRMAEKNSNMIIAGLCQLRKNQVEITMDALRPSLAIGKARVHMYLPVDPNLAQASLGSKN 123 Query: 114 TLDEVIERAIYMVKRARNYTDDVEFSCEDAGR--TPIADLARVVEAAINAGATTINIPDT 171 ++ I+ ++K A + +VEFS E R + V AA++AG T IN PDT Sbjct: 124 DNEQNIKNVYELIKLASDQGFEVEFSAEGYSRLGDTFDYVTDVFRAAVSAGVTVINCPDT 183 Query: 172 VGYTMPFEFAGII--------SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAG-A 222 +G E + + P+ I S H H+DLGLA+ NS+ AV G A Sbjct: 184 IGGACERENDNYFVKNMTKHAEIIKKEFPD-KNIIWSAHCHNDLGLALENSMNAVFDGPA 242 Query: 223 RQVEGAMNGIGERAGNCSLEEVIMAIKV--RKDILNVHTAINHQEIWRTSQLVSQICNMP 280 QVEG +NG+GERAGN SLE+ +M I + ++ + + IN S + + + Sbjct: 243 TQVEGCINGVGERAGNASLEQCVMFINLFGKQKDCHFYNDINIANFKTISDFIGKRM-LS 301 Query: 281 IPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHR 340 + I G + H+SG H + +L N Y+ PES+G N+I SG K Sbjct: 302 RQPHHPITGLNSARHTSGGHTNAILNNPLAYQPFHPESVG-NEISFIFGPLSGGNHAKKI 360 Query: 341 MDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQS 400 ++E GY + + + ++ + + A+ KQ + P H + + Sbjct: 361 IEENGYICDDKEKAAIAQQIKDIYHERRKGITDEELIQAY--KQIKSPIHVSAIDYGKSN 418 Query: 401 GSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAK-GHGKD 459 G + + + N + A+ + I +V + Y + G + Sbjct: 419 GETYVELKGRFFGNTDYRITDRGE-NSALSALLKGIQEYIP-DVNISDYFSRSLKDAGIN 476 Query: 460 ALGQVDIVANYNGRR--FHGVGLATDIVESSAKAMVHVLNNIW 500 + + I+ G+ + DI SS KA++ N ++ Sbjct: 477 SKSETTIIIKTGENSPVVEGIAVDQDIEISSLKALITATNKLY 519 >UniRef50_B8FRV4 2-isopropylmalate synthase n=2 Tax=Desulfitobacterium hafniense RepID=B8FRV4_DESHD Length = 404 Score = 299 bits (765), Expect = 2e-79, Method: Composition-based stats. Identities = 88/382 (23%), Positives = 168/382 (43%), Gaps = 14/382 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + Q++ I D TLRDGEQ S ++K++IA L +GV+ +E G P S D ++++ Sbjct: 27 LPQKIEIHDATLRDGEQTPGVVFSKEDKVRIAELLAEVGVERIEAGMPAVSKDDAQAIEE 86 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKL--RSTLDEV 118 IA++ ++ R + +D+D A + A I + + + + T + + Sbjct: 87 IAKRNLGPKIMVFCRAMREDVDRAVD----CGADGIVLEAPSGYPKLKYQFASKWTEESL 142 Query: 119 IERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVV-EAAINAGATTINIPDTVGYTMP 177 E + + A+ V + D R + L R++ A ++ + DT G P Sbjct: 143 TEAVVNTINYAKEKGLFVNYFPFDTTRAELPFLKRLLTNVTTQAKPDSVTVVDTTGSITP 202 Query: 178 FEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 ++ + E + + VHTH+D GL + AAV G + V +NG+GER G Sbjct: 203 TAMRFLVRQVRETI----ALPLEVHTHNDFGLGTATTFAAVEEGVQVVHSCINGLGERTG 258 Query: 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 N +LEE+ + +K+ I N Q++ SQ V ++ + NK +VG F Sbjct: 259 NTALEEIALGLKLLYGIE--LPKFNFQKLSELSQEVQRMSGKTLAQNKPVVGLLPFTREI 316 Query: 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 G+ + P+ +G ++++ + +SG+ +V +++ G K +E + + Sbjct: 317 GLGMKVLEDYPTAVFPFMPDFVG-QKMKIVMGKKSGKESVLMKLEAAGLKANEEQVQEIV 375 Query: 358 DAFLKLADKKGQVFDYDLEALA 379 K + + + Sbjct: 376 ARTKAAGIAKRNWLEDEEFLVI 397 >UniRef50_A2QSZ0 Contig An09c0020, complete genome n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2QSZ0_ASPNC Length = 566 Score = 296 bits (758), Expect = 1e-78, Method: Composition-based stats. Identities = 115/537 (21%), Positives = 203/537 (37%), Gaps = 51/537 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 ++Q T LRDG QAL ++ KL+ L ++G +EV +P +S +F+ + Sbjct: 29 LTQAPRWLSTDLRDGNQALVQPMNGDLKLRYFQTLIKLGYKEIEVSYPSASQTEFDFTRY 88 Query: 61 IARQV----KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 + ++ + +A C ++ I E+++ A +H ++TS + T Sbjct: 89 LISTPGIVPDDTWIQVMAPCRDELIQRTIEAVRGARKVVLHIHLSTSDLFREIVYLMTKK 148 Query: 117 EVIERAIYMVKRARNYTDD------------VEFSCEDAGRTPIADLARVVEAAINAGAT 164 E+I+ A+ ++ R T D +EF+ E+ T + + EA A Sbjct: 149 EMIDLAVRCMRMIRELTKDSLDAEMRKTEWTMEFTLENFQDTSVEFALEICEAVKAAWEP 208 Query: 165 T------INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAV 218 T N+P TV +MP FA I + +K +SVH H+D G V + A Sbjct: 209 TTENKIIFNLPSTVEISMPNVFADQIELFCRGISEREKVCVSVHPHNDRGCGVAAAEMAQ 268 Query: 219 HAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICN 278 AGA +VEG + G GER GN L + + + + + +N + +V Sbjct: 269 LAGADRVEGCLFGNGERTGNVDLVTLALNLYTQG----ISPRVNLGNLNEVVAMVEDCTK 324 Query: 279 MPIPANKAIVGSGAFAHSSGIHQDGVLKN------------------RENYEIMTPESIG 320 +PI G F +G HQD + K R Y M P +G Sbjct: 325 IPIHPRAPYAGKYVFCTFTGTHQDAIRKGYNQLQESEKHDATQTPKWRMPYLPMDPADLG 384 Query: 321 LNQIQLN-LTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKG--QVFDYDLEA 377 + + S+SG++ V ++E + L+ + +K ++ + Sbjct: 385 RQHEAIVRVNSQSGKSGVAWLLEESFHIHMPRELEIEFTKIVKTYANMSGFEITQETIRR 444 Query: 378 LAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAV--KLACGEEVKAEAANGNGPVDAVYQA 435 L + E RL D V K+A A G+ + + A Sbjct: 445 LFREHYMHADSEKARLLDCRADETKGDRVVTQVQLKVAVEGSEHDLEATGSELLPTILDA 504 Query: 436 INRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAM 492 + + Y E + + + V + + N GVG+ D + + A+ Sbjct: 505 L-KPLGYGFEALDSQMQYTTNRDTITSFVRLGTSEN-FAAWGVGMHKDTAWAVSLAV 559 >UniRef50_Q1IYY1 Homocitrate synthase n=1 Tax=Deinococcus geothermalis DSM 11300 RepID=Q1IYY1_DEIGD Length = 389 Score = 296 bits (757), Expect = 2e-78, Method: Composition-based stats. Identities = 92/377 (24%), Positives = 171/377 (45%), Gaps = 10/377 (2%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I D+TLR+GEQ + + +K++IA L+ G + +EV P+ ++ + Sbjct: 17 IIDSTLREGEQFARGNFKTGDKIEIARLLDAFGAEFLEVTTPMVGAQTQADIRRLTSLGL 76 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 N+++ RC +D+ A + + TS ++ ++I+ A ++ Sbjct: 77 NAKILTHVRCHLEDVQRAVD----LGVDGLDLLFGTSSFLREFSHGKSIAQIIDTASEVI 132 Query: 127 KRARNY--TDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 + ++ FS ED R+ ADL V A + G + + DTVG P + ++ Sbjct: 133 GWIKQNHPDLEIRFSAEDTFRSEEADLMAVYRAVSDLGVHRVGLADTVGVATPRQVYTLV 192 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + + + + I H H+D G AV N+ A+ AGA ++ + GIGER G L Sbjct: 193 REVRKVIHA--ECGIEFHGHNDTGCAVSNAYEAIEAGATHIDTTILGIGERNGITPLGGF 250 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 +A D + N + + +L++++ ++PIP N + G A+ H +G+H + Sbjct: 251 -LARMFTFDPQGLIDKYNLELLPELDRLIARLVDLPIPWNNYLTGEFAYNHKAGMHLKAI 309 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 N YE + P G+ + + +G+ A+ H+ E+G E L + D LA Sbjct: 310 YLNPGAYEAIPPSVFGVGRRIQAASKVTGKHAIAHKARELGLHYGEDALRRVTDHIKALA 369 Query: 365 DKKGQVFDYDLEALAFI 381 ++ G++ D LE + Sbjct: 370 EE-GELDDAHLEQVLRE 385 >UniRef50_Q04QM8 Isopropylmalate/homocitrate/citramalatesynthase n=15 Tax=Leptospira RepID=Q04QM8_LEPBJ Length = 435 Score = 292 bits (749), Expect = 2e-77, Method: Composition-based stats. Identities = 117/381 (30%), Positives = 195/381 (51%), Gaps = 18/381 (4%) Query: 1 MSQQV-IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQ 59 + + D TLRDG QAL+ + +K I L ++GV +EVGF S+ +F++ Sbjct: 36 LPKHPPFFMDVTLRDGNQALRKPWDLDQKETIFKQLIKLGVQGIEVGFASSNSQEFKTCS 95 Query: 60 TIARQVK-NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEV 118 ++ N + +L+R VEK+I ++ ++++ A RIH S I L+ + ++V Sbjct: 96 RLSSIAPDNVVISSLSRAVEKEIKISWKAIRHASKPRIHIVYPISAFTIQNVLKLSPEKV 155 Query: 119 IERAIYMVKRARNYT---DDVEFSCEDAGRT--PIADLARVVEAAINAGATTINIPDTVG 173 +E+ V A++ +++FS E G + + A+N GA IN+P+TV Sbjct: 156 LEKISESVSFAKSLVGSKGEIQFSGEHFGDSLENLDFAVEAFRTALNYGADIINLPNTVE 215 Query: 174 YTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIG 233 P+ F ++ + +P A ISVHTH+DLG+A ++ + +GA Q+E A+NG+G Sbjct: 216 RYRPWLFVSMVKAVRNVLPE--NAKISVHTHNDLGMATATTVESYFSGAVQLETALNGLG 273 Query: 234 ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAF 293 ERAGN + EV +A+ V +N I+ TS+LVS + N+PI +VG Sbjct: 274 ERAGNTNTYEVAIALHN----CGVDVPLNLSAIYETSRLVSYLSNVPIYEKAPLVGEDVI 329 Query: 294 AHSSGIHQDGVLKNRE----NYEIMTPESIGL-NQIQLNLTSRSGRAAVKHRMDEMGYKE 348 +H SGI+QDGV K R Y IG + ++ TS+SGR+A+ + + G Sbjct: 330 SHRSGIYQDGVAKTRHLSKGAYRAFNATLIGRPEEDRIEFTSQSGRSAIFCILKDAGEDI 389 Query: 349 SEYNLDNLYDAFLKLADKKGQ 369 + L K+++ G+ Sbjct: 390 TLEQAGKLQPILKKISEDSGK 410 >UniRef50_Q0W3Q1 2-isopropylmalate synthase n=8 Tax=Archaea RepID=Q0W3Q1_UNCMA Length = 468 Score = 292 bits (747), Expect = 3e-77, Method: Composition-based stats. Identities = 109/398 (27%), Positives = 178/398 (44%), Gaps = 24/398 (6%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 S ++ I DTT+RDG Q + KLQI L MGV+ +E V + D ++ +++ Sbjct: 16 SAEIKISDTTIRDGCQMPGVVMKKSHKLQIFEYLHEMGVEKLET--FVYNDRDKDACKSM 73 Query: 62 AR-QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLR-STLDEVI 119 + V AR DID E LKV ++ S HI K+ + E Sbjct: 74 MDYGYEFPEVTGWARANPADID---EVLKVDGIRETGILMSVSDSHIFDKMGLKSYAEAE 130 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTI-NIPDTVGYTMPF 178 ++ + ++ A ++ ED R + V+ I TI I DT+GY +PF Sbjct: 131 QKYLKALQYAIDHGLKTRCHIEDTSRANYEFVYPFVQKLIEIDPDTIIRICDTLGYGIPF 190 Query: 179 EFAGI---ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGER 235 I + + + + I +H HDD GL +GN+LA + GA GIGER Sbjct: 191 PGYEEPYGIPTVVKNLKEMGVKHIEMHVHDDFGLGIGNTLAGLWYGADWASLTFLGIGER 250 Query: 236 AGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAH 295 AGN LE+++ + R + N Q+ ++ + Q + +P NKAIVG F+H Sbjct: 251 AGNTELEKIMAFLITRVEGFE---KYNLQKATEFAEYMEQEIGLRVPRNKAIVGKNIFSH 307 Query: 296 SSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDE-----MGYK--- 347 SGIH G++KN YE PE +G + L + SG ++ +++E +G K Sbjct: 308 ESGIHTAGIIKNPFTYEPFPPELVGGKRN-LMIGDTSGTDVIRLKVEEALSELLGIKAQV 366 Query: 348 -ESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQ 384 + + + ++ K+ D + + E L ++ Sbjct: 367 NKHDPRIKCIHKDIQKMYDAEDRRSSVSDEELHDFVRK 404 >UniRef50_C7LNR6 Pyruvate carboxyltransferase n=1 Tax=Desulfomicrobium baculatum DSM 4028 RepID=C7LNR6_DESBD Length = 373 Score = 291 bits (744), Expect = 6e-77, Method: Composition-based stats. Identities = 98/367 (26%), Positives = 173/367 (47%), Gaps = 15/367 (4%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 ++ DTTLR+G Q S+ + K++IA + MGV+ +E+G+ + G E V+ + + Sbjct: 1 MLIDTTLREGAQMFGTSIPQEAKIRIAGRIADMGVEEIEIGW-MGQEGLDEVVKALRGRG 59 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 + + C D+ AA I+ + S +HIA +LR+ D + Sbjct: 60 VTCDLSVWSPCRTVDVYRAA----GLSIDTINIGLPVSDLHIAERLRTDRDGLTRMLRET 115 Query: 126 VKRARNYTDD-VEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 V A + + ED R + A GA I + DT+G P A ++ Sbjct: 116 VGLAHSCGIRRISIGLEDVTRADQDFALSMARMAKELGAARIRLADTLGVMTPTRIAELV 175 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + V I++H H+D G+A N++ A+ AGA + ++ GIGER+G +LEEV Sbjct: 176 RFFAQSV----DMEIAIHCHNDFGMATANAITALEAGAHWADVSVLGIGERSGISALEEV 231 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 +++ + + + LV++ +P+ N+ + G FA SG+H DG+ Sbjct: 232 AGHLRLVQGYDIYDMNL----VRALCDLVAEYARIPVARNRPMSGGDIFAAESGLHVDGI 287 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 LKN +E P G +I L L +++GR AV+ + ++G K +++ N+ D + A Sbjct: 288 LKNPALFEPYDPAQTGAKRI-LALGAKAGRGAVRTMLRQVGLKGPLHSIGNMVDTIRERA 346 Query: 365 DKKGQVF 371 + G+ Sbjct: 347 HRTGRPL 353 >UniRef50_C9YAE2 Putative uncharacterized protein n=1 Tax=Curvibacter putative symbiont of Hydra magnipapillata RepID=C9YAE2_9BURK Length = 285 Score = 290 bits (743), Expect = 8e-77, Method: Composition-based stats. Identities = 124/223 (55%), Positives = 159/223 (71%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+ ++IIFDTTLRDGEQ+ AS++ EKL+IA LER+ VDV+E GF SS GDFE+VQ Sbjct: 1 MTDKLIIFDTTLRDGEQSPGASMTRDEKLRIARQLERLRVDVIEAGFAASSNGDFEAVQL 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 IA +K+S VC+L+R ++DI AAE+LK A + RIHTFIATS +H+ KLR T ++V+E Sbjct: 61 IANSIKDSTVCSLSRANDRDIARAAEALKGANSARIHTFIATSALHMEKKLRMTPEQVLE 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 +A V+ ARN D+EFS ED R+ L RV+EA I GA+TIN+PDTVGY +P + Sbjct: 121 QAKQSVRFARNLVADIEFSPEDGYRSDPDFLCRVLEAVIAEGASTINVPDTVGYAVPELY 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGAR 223 I L ER+PN DKAI SVH H+DLG+AV NSLA V G Sbjct: 181 GNFIKNLRERIPNSDKAIWSVHCHNDLGMAVANSLAGVKIGGG 223 >UniRef50_C6BX35 Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio salexigens DSM 2638 RepID=C6BX35_DESAD Length = 368 Score = 290 bits (743), Expect = 9e-77, Method: Composition-based stats. Identities = 105/368 (28%), Positives = 181/368 (49%), Gaps = 17/368 (4%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR-Q 64 ++ DTTLR+G Q A +++ + +IA +L MGVD +E+G+ D AR Sbjct: 1 MLIDTTLREGAQLFGAYFNLETRKRIASSLISMGVDEIEMGW--VGQDDLALFAGYARTL 58 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 ++ + + C EKDI+VAAE RI+ + S +HI +L S ++ + Sbjct: 59 GGDTALSVWSPCREKDIEVAAE----LGLKRINIGVPVSDLHIEKRLDSDRQAILRKLAA 114 Query: 125 MVKRARNYTDD-VEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 V+ A++ + V ED R + A GA+ + + D++G P + Sbjct: 115 AVRTAKDCGFEYVSVGLEDISRADGDFALSMALHAEICGASRVRLADSLGQLTPLAMEKL 174 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 + E++ I+VH HDD G+A NS A+ AGA + ++ GIGER+G + EE Sbjct: 175 VRKFREKLH----IDIAVHCHDDFGMATANSFTALEAGADYADCSVIGIGERSGIAATEE 230 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 ++ + +R+ T + + +V + IP KA+VG+ FA SG+H Sbjct: 231 LVARLALREGNTRYSTTV----LKDACMVVGAAAKVAIPRTKAVVGTDIFACESGLHTHA 286 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 + K+ E +E P+S+G + +L + +SGRAAV++ +DE G +L L +A +L Sbjct: 287 LSKSPELFEPYDPDSVGTVR-KLAVGGKSGRAAVRNALDEYGIDCGTDSLSTLTEAVRQL 345 Query: 364 ADKKGQVF 371 + + + Sbjct: 346 SLRLERPL 353 >UniRef50_Q10Y65 2-isopropylmalate synthase n=1 Tax=Trichodesmium erythraeum IMS101 RepID=Q10Y65_TRIEI Length = 462 Score = 288 bits (737), Expect = 3e-76, Method: Composition-based stats. Identities = 105/351 (29%), Positives = 162/351 (46%), Gaps = 23/351 (6%) Query: 5 VIIFDTTLRDGEQ-ALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 V I D+TLR+G Q A + S ++ L+IA L +G+D++EV PV S + V+ I Sbjct: 2 VQIVDSTLREGRQTAPGINFSWEQSLKIAKLLHSLGIDIIEVCHPVVSIEQKQIVREIVA 61 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 V A AR DI E++K A + F+ + T+ R T+ ++ Sbjct: 62 SNL-CPVIAHARANLADI----EAVKETSAQWVGIFLGINEETRLTRARWTISKIFNCIK 116 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 V A+ V ++ EDA RT L V AI AGA I DTVG P E Sbjct: 117 ESVMYAKTLGLKVRYTAEDASRTDYCLLKSVYSVAIEAGADCICFSDTVGIMEPNEVTET 176 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 I L + + VH H+D GLA+ N+LAA AGA ++ ++NG+GER G Sbjct: 177 IEKLKS---DFSTVPLEVHFHNDRGLAMANALAASDAGAERISSSVNGLGERCGITDTLG 233 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 +++ + + I I RTS+ V+ P+ N+ I G AF H++ +HQ Sbjct: 234 LLVNLYYKGLRSLPSGEI----IQRTSKYVAAFSRYPVNFNQPISGGNAFIHTAHLHQKA 289 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAA-------VKHRMDEMGYK 347 V ++ +Y + PE +G + L+ +S + + E+GY Sbjct: 290 VKRDPSSYSWILPEYVGKT---MELSGKSIPSVHSLFLTPIVKCASELGYH 337 >UniRef50_C0AC93 Trans-homoaconitate synthase n=2 Tax=Opitutaceae bacterium TAV2 RepID=C0AC93_9BACT Length = 397 Score = 285 bits (730), Expect = 3e-75, Method: Composition-based stats. Identities = 121/371 (32%), Positives = 177/371 (47%), Gaps = 12/371 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 ++ + DTTLRDGEQA S +KL IA AL V +EVG P + G + + + Sbjct: 6 PHRLHLIDTTLRDGEQAAGVVFSQADKLAIARALVEARVPELEVGIPAAGAGAIDDINAV 65 Query: 62 ARQV-KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 A V +R+ R + DI +A + +H S +H+ +T V+ Sbjct: 66 ADAVAGRARIITWCRALPGDIALA----RACRVTGVHLSFPVSNIHMRI-WGATPATVLA 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 + AR + D V +DA R LA AA A + + DTVG+ P + Sbjct: 121 SLDELTAAAREHFDQVTVGAQDASRADPGFLAEFAAAAARTPAVRLRLADTVGFLTPDKT 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 AG+ S L P + + +H H+DLGLA N+LAA AGA +NG+GERAGN + Sbjct: 181 AGLTSHLRHAAPALP---VEIHAHNDLGLATANTLAAFSAGASAASLTVNGLGERAGNAA 237 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV+MA+KV + I I+ S LV++ P+P K +VG+GAF H SGIH Sbjct: 238 LEEVVMALKVAQGI---DCGIDTSRFVELSALVARASRRPVPVQKPVVGAGAFLHESGIH 294 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 G+L++R +YE P +G L + +G AAV + G ++ +L + Sbjct: 295 CAGLLRDRRSYEPFDPADVGHAASDFVLGAHTGGAAVAAALATCGVTLAKTEARHLAEEV 354 Query: 361 LKLADKKGQVF 371 A G Sbjct: 355 RSRAQASGVPL 365 >UniRef50_D1U2X4 Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio aespoeensis Aspo-2 RepID=D1U2X4_9DELT Length = 377 Score = 283 bits (724), Expect = 1e-74, Method: Composition-based stats. Identities = 94/386 (24%), Positives = 168/386 (43%), Gaps = 12/386 (3%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 ++ DTTLR+G Q A ++ + I L +GV+ +E+G+ V G V+T+ ++ Sbjct: 1 MLIDTTLREGAQLFGAYFTLDTREAIIAGLLDLGVEEIELGW-VGQEGLETLVRTMRKRA 59 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 +R+ + C E D+ AA ++ + S H+ +L V+ER Sbjct: 60 GATRLSVWSPCREADVRAAA----GLPVDCVNIGVPVSDAHMEKRLGMDRQAVLERITST 115 Query: 126 VKRARNY-TDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 V AR V ED R+ + A AGA+ + + D++G P +I Sbjct: 116 VLAARLMDVSAVSVGLEDVSRSDLGFALTAALTAAEAGASRVRLSDSLGILTPVRMQALI 175 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + ++VH HDD G+A N++ A+ AGA + ++ GIGER+G + EE+ Sbjct: 176 DLFRPAL----DIDLAVHCHDDFGMATANAVTALDAGADYADASVLGIGERSGIAATEEL 231 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 + + + + + VS+ +PIP K+I G FA SG+H + Sbjct: 232 AAHLCLNGNNSPCRP-YRTDGLRALCRFVSKAAGVPIPRTKSIAGDDIFACESGLHAHAL 290 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 K+ + +E P IG + ++ + +SGR AV + + + + + NL + + A Sbjct: 291 SKSPDLFEPYDPARIGAGR-RIAVGGKSGRGAVVNALADFNLHCPDTAIPNLVNTVRQRA 349 Query: 365 DKKGQVFDYDLEALAFIGKQQEEPEH 390 + + A G + E Sbjct: 350 WELRRPLTRTEFARLTEGCRDSEKNR 375 >UniRef50_B0PEC7 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PEC7_9FIRM Length = 403 Score = 282 bits (722), Expect = 2e-74, Method: Composition-based stats. Identities = 95/382 (24%), Positives = 161/382 (42%), Gaps = 18/382 (4%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + I D TLRDGEQ L+ +K+ +A + +G+ +E G P S D +V I ++ Sbjct: 30 IKIHDVTLRDGEQQAGLVLTCDQKIALAEKMAELGIHRIEAGMPAVSAEDARAVSEIVKR 89 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 + + ARC+ D+ AA+ I I ++ I +L++ +E ++ Sbjct: 90 RLPTEIFGFARCMVDDVKRAAD----CGVSGIVIEIPSNEEMIREAYGWSLEKAVELSVK 145 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVV-EAAINAGATTINIPDTVGYTMPFEFAGI 183 K A+ F D R I + +++ + A + + + DT+G P + Sbjct: 146 ATKAAQGAGLYTVFFPIDMTRANIDWVLKLIGQVAADGHMDALAVVDTMGGLAPHTVPYL 205 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 I + R+ + VH HDD GL V NS+ + AGA V ++ GERAGN + E Sbjct: 206 IDAIKSRI----DKPLEVHFHDDFGLGVANSIMGLAAGADVVHTTISACGERAGNAAYEH 261 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 + +A+ +++ +I+ S+L+ ++P+ N ++G F SGI G Sbjct: 262 LALALLTMYG---YDLGLDYSKIYSLSKLLRSFIDLPVRGNMGVIGDRVFDIESGI-VAG 317 Query: 304 VLK-----NRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYD 358 K N PE G ++ L SG ++ D + K + +L Sbjct: 318 WYKNVKNTNPLLVTPYLPELTGHPGTEVVLGKHSGGPSIDCWADRLHIKLDKEQKSDLLG 377 Query: 359 AFLKLADKKGQVFDYDLEALAF 380 A KKG D L F Sbjct: 378 QIKLAACKKGNTLDEQEVRLLF 399 >UniRef50_C6A4Y6 2-isopropylmalate synthase 1 n=1 Tax=Thermococcus sibiricus MM 739 RepID=C6A4Y6_THESM Length = 418 Score = 278 bits (711), Expect = 4e-73, Method: Composition-based stats. Identities = 100/395 (25%), Positives = 185/395 (46%), Gaps = 20/395 (5%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 ++V++ D T+R+G+Q + E + IA AL+ +G+D +E+ P S D E+ + + Sbjct: 37 PERVVLHDATIREGQQMPGVAFKRDEIVMIAKALDELGIDRIEL-IPFLSKDDEEAAKEL 95 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 N+++ + ++D D+A LK+ + F+ +P +E+IER Sbjct: 96 VDMGLNAKLLSFVSWKKEDTDLA---LKLDLEGVVLDFVG-NPWQGKVFWNLKPEEIIER 151 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 + A+++ V D + P+ + + V+A A I I DT G +P+ Sbjct: 152 GVNAALYAKDHGLYVVAMPWDDFKAPLDFVEQNVKALTEAHVDRITICDTYGDALPWAME 211 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 ++ L + DK + +H H+D GLA +L AV +G + +NG+GER G SL Sbjct: 212 YVMKRLKKAA---DKTPLELHIHNDFGLATAGALVAVASGVEGLHVTVNGLGERVGLLSL 268 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EE+ +A++ V T IN ++++ S++V +I + + NK IVG+ F +++G Sbjct: 269 EEIAVALEFLLG---VKTNINLEKLYEISKIVEEISKVKVAVNKPIVGANQFKYTAGWIT 325 Query: 302 DGVLKNRENYE-----IMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK-ESEYNLDN 355 K RE + PE++G Q+ ++ SG + V ++ E+G E + Sbjct: 326 WMHRKAREAGKLTGMLPFMPEAVGR-QLDYVVSKGSGASFVAEKLAELGITVEDPEKMKI 384 Query: 356 LYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEH 390 + + A+ L L I ++ E E Sbjct: 385 IARKVKETANTLKSTVPDSL--LIKIAREVLEKEG 417 >UniRef50_B9YLN5 2-isopropylmalate synthase n=2 Tax=Nostocaceae RepID=B9YLN5_ANAAZ Length = 394 Score = 277 bits (710), Expect = 5e-73, Method: Composition-based stats. Identities = 106/379 (27%), Positives = 187/379 (49%), Gaps = 15/379 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + I D+TLR+GEQ S K KL IA L+R+G+D++EVG P ++ IA Sbjct: 2 IQILDSTLREGEQTPGVYFSPKTKLVIAQFLDRIGIDIIEVGNPAVDTEIALAINQIANA 61 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 +++ A + C + A + + + F + SP + L+ I++ + Sbjct: 62 GLKAKIGAHSLCKIDSVQKALD----CDVDFLGIFFSVSPQRLYRDYNICLERAIDKIVE 117 Query: 125 MVKRARNYTDD--VEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE--- 179 ++ AR D + ++ ED R+PI ++ +AA+ AGA I+I DT GYT PF Sbjct: 118 VISYARTQKSDLLIRYTPEDTVRSPIENVIAAAKAAVQAGANIISIADTTGYTNPFHPQR 177 Query: 180 -FAGIISGLYERV-PNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 + + E + I VH H+D GLA+ N L A AGA ++ A+ G+GERAG Sbjct: 178 SIYFYVKTVKEELGKEGLYPQIEVHCHNDKGLALANVLDAYRAGADIIDVAVMGLGERAG 237 Query: 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 L E+++ + + N ++++ VS+ ++ IP ++A+ G AF H + Sbjct: 238 IVDLAELLINLIDMDEEGNFWQLNYLKDLY---DFVSEQSHISIPPHQAVTGKYAFTHYA 294 Query: 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 G+H V K+ Y+ + P+ +G+ + L +SG AAV+ + ++G ++ N D + Sbjct: 295 GVHVKAVAKDERLYQSLNPQILGIK-SSVALGMQSGCAAVELAIKQIGREDLARNKDLIT 353 Query: 358 DAFLKLADKKGQVFDYDLE 376 ++ + + D+E Sbjct: 354 KILKEIKEISKRGTPIDIE 372 >UniRef50_C8W3E1 Pyruvate carboxyltransferase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8W3E1_DESAS Length = 287 Score = 277 bits (708), Expect = 9e-73, Method: Composition-based stats. Identities = 85/279 (30%), Positives = 138/279 (49%), Gaps = 11/279 (3%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 +V I DTTLRDGEQ+ + S KEK++IA L+ +GV+ +E+G P + +++ +IA Sbjct: 3 KVCIVDTTLRDGEQSPGVAFSAKEKIKIAQYLDLLGVEQIELGIPAMGGIEVDAISSIAS 62 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 +R+ R DI + +H S + I KL + V++ Sbjct: 63 LDLKARLTTWNRLHLSDIRASL----SCRVKNLHICAPVSDIQIEYKLNKSRLWVLDCLK 118 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 ++ A++Y + EDA R L A GA + DTVG PF Sbjct: 119 RAIRYAKDYGCWISVGAEDASRADPEFLLEYALLAQEMGAERLRYADTVGVLEPFSTYRE 178 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 +S L +++ K + H H+D GLA N++AAV+AG R ++ +NG+GERAGN ++EE Sbjct: 179 LSWLKDKL----KIELEFHGHNDFGLATANTVAAVNAGVRFIDVTVNGLGERAGNANMEE 234 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIP 282 V+ AI++ I + ++ S V++ N +P Sbjct: 235 VVAAIRMSCGIG---MNWANDKMKALSSYVARASNRKMP 270 >UniRef50_Q2GMU3 Putative uncharacterized protein n=1 Tax=Chaetomium globosum RepID=Q2GMU3_CHAGB Length = 828 Score = 276 bits (706), Expect = 2e-72, Method: Composition-based stats. Identities = 101/526 (19%), Positives = 194/526 (36%), Gaps = 63/526 (11%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESV-Q 59 +++ T LRDG QAL + + L +G +EVGFP SS DF+ + Sbjct: 52 ITKPPRWLSTDLRDGNQALASPM----------MLVDIGFKEIEVGFPASSEMDFQFAQR 101 Query: 60 TIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + + + + C + I +++K A+ + +IATS I T +T + + Sbjct: 102 CVLDGPPDVWLEVMTPCRKDFIRRTVDAVKGAKKIIVSLYIATSDNFIDTIFSTTREAQL 161 Query: 120 ERAIYMVKR----------ARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGAT----- 164 A+ + ++ T + +S E T + A A Sbjct: 162 RTAVEHARYLKTVTKDDPAHKDTTWALMWSPEAFSDTDPDFAIEICRAVKEAWEPSAEVP 221 Query: 165 -TINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGAR 223 +N+P TV + P FA + +S+H H+D G AV + AGA Sbjct: 222 IILNLPATVEMSSPNIFADQVEIFSRGFSGDPTVCVSLHNHNDRGCAVAAAELGQLAGAT 281 Query: 224 QVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 +VEG + G GER GN L + + + + + ++ ++ R ++V Q+ +P+ Sbjct: 282 RVEGCLFGNGERTGNVDLVTLALNLYTQG----IDPGLDFSDLPRIRRIVEQLTQIPVHT 337 Query: 284 NKAIVGSGAFAHSSGIHQDGVLKNRENYE-------------------IMTPESIGLN-Q 323 G F SG HQD + K + + M P IG + + Sbjct: 338 RAPYAGDSVFVAYSGGHQDAINKGFKRWNATANDDKHGRPRPWKVPYLAMDPHDIGASYE 397 Query: 324 IQLNLTSRSGRAAVKHRMDE-MGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIG 382 + + S+SG+ + + + + + + L A ++ KG+ + F+ Sbjct: 398 AVIRVNSQSGKGGIAWVLSQALQLEAPKAILGAFSLAVKSESELKGRTLLPNEVTNLFLR 457 Query: 383 KQQEEPEHFRLDYFS----VQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINR 438 + + + R+ S S + + + +G +DAV ++ Sbjct: 458 QYNVQSQDQRVLSLVKTALNSSDSGSLVRVETVILVNGLARQLVGHGASTLDAVRFGLSA 517 Query: 439 ITEYNVELVKYSLTAKGHGK------DALGQVDIVANYNGRRFHGV 478 + +E + G ++ ++ + GR GV Sbjct: 518 FADCRLEFT-CAFGTPSAGIVNSNLPESSVIAIVMCSGGGRTTWGV 562 >UniRef50_P70728 Homocitrate synthase n=1 Tax=Azospirillum brasilense RepID=NIFV_AZOBR Length = 376 Score = 275 bits (704), Expect = 2e-72, Method: Composition-based stats. Identities = 102/359 (28%), Positives = 159/359 (44%), Gaps = 22/359 (6%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+ II DT RDGEQ + ++ EK+ IA AL+ GV +E+G P + E ++ Sbjct: 1 MAGSTIINDTHARDGEQTAGVAFTLDEKIAIAQALDEAGVAELEIGIPAMGREERERIRA 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 +A +R+ R + D+ + ++ + + S +HI KL + + Sbjct: 61 VASLGLKARLMVWCRMHDTDLKARSTAVAPS------LSVPVSDIHITKKLNGSRAWALR 114 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 VK AR++ +V ED+ R + L + AA A DT+G PF+ Sbjct: 115 EIERKVKTARDHGLEVSLGGEDSSRADMDFL---IAAATVAQRPRFRFADTLGVLDPFQH 171 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 A + P I HT +LAAV GA V +NG+GERAGN Sbjct: 172 ARLHLTAAATDPEIG---YHAHTPRLANATAWVTLAAVLGGATHVNTTVNGLGERAGNAP 228 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV++++KV ++ + + S LV + N P+ NK+IV F H +GIH Sbjct: 229 LEEVVVSLKVLYG---QDCGVDTRALGAISDLVERASNRPVAVNKSIVRDAVFTHEAGIH 285 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 DG+L +R I TP G ++ S A++ R E G ++ D+ Sbjct: 286 VDGLLTDRAPTRISTPPRWGA-------STASCWASIPARGGEDGLRQLGIACDDATAQ 337 >UniRef50_C0Z7H0 Alpha-isopropylmalate/homocitrate synthase family protein n=5 Tax=Bacillales RepID=C0Z7H0_BREBN Length = 472 Score = 273 bits (698), Expect = 1e-71, Method: Composition-based stats. Identities = 93/323 (28%), Positives = 156/323 (48%), Gaps = 13/323 (4%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + I D TLR+GEQ + ++K++I LE ++++EVG P S D E + +A Sbjct: 2 KPFQILDATLREGEQQAGVRFTCEDKIRILHLLESYQINLIEVGHPGISALDEEICRKVA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD-EVIER 121 + + +++ AR +++ A K A+A + + + + + I TK R + ++E+ Sbjct: 62 QSARRAQILMHARATVEEVHAA----KRAKADWVGIWASINDVSIQTKFRHHEESYILEK 117 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 V A+ V F+ EDA RT ++ + AA+ AGA I++ DTVG P Sbjct: 118 VQQAVIEAKKLGLQVRFTIEDASRTEWEKISSLGYAALQAGADRISLADTVGIWEP---- 173 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 + R I VH H+D GLA N+LAA+ AGA ++ + GIGERAG L Sbjct: 174 DTCKKIVTRAIEEFGCEIEVHLHNDFGLAQANALAAIDAGASVIDATILGIGERAGITDL 233 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 ++ +A++ ++ + I Q + + I G AF H+S H Sbjct: 234 IQLTVALQKLRN----DHRYSLDRIPELVQAIRLTTGYRPDELRPITGQNAFTHTSAYHV 289 Query: 302 DGVLKNRENYEIMTPESIGLNQI 324 V +N + YE + PE+IG ++ Sbjct: 290 QAVKRNSKAYEPLPPETIGRTRL 312 >UniRef50_Q46A98 Homocitrate synthase n=2 Tax=Methanosarcina RepID=Q46A98_METBF Length = 287 Score = 271 bits (692), Expect = 7e-71, Method: Composition-based stats. Identities = 82/286 (28%), Positives = 133/286 (46%), Gaps = 11/286 (3%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I DTTLRDGEQ+ SV+E++ I AL++ V +E G P + E ++ + Sbjct: 9 IIDTTLRDGEQSAGVVFSVEERMNIISALDKAKVKWIEAGIPAMGKQECEDLKLMLNLPI 68 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 S + A R +D+ + + +H + S +HI KL+ + V+++ + Sbjct: 69 KSNLIAWNRANLEDLKASID----CGFKFVHVSLPVSDLHIEHKLQKSRTWVLDQLKKCM 124 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 + ++ + EDA R L + A + GA I DTVG F I Sbjct: 125 EYLQSCKVTIIVGAEDASRADPEFLLQYAGIAASYGAIRIRYSDTVGCLDHFTTYRKIKE 184 Query: 187 LYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIM 246 + + P + +H H+D GLAV N+LAA AGA+ + G+GERAGN S+EE Sbjct: 185 IADHSP----PPVEIHAHNDFGLAVANTLAAYKAGAKFASVTVTGLGERAGNASMEETAF 240 Query: 247 AIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 ++ K N I + + +++VS+ + K +VGS A Sbjct: 241 SL---KRFYNYDCGIELEALPFLAEMVSKASERTLFPYKPLVGSLA 283 >UniRef50_C0GSN3 Pyruvate carboxyltransferase n=1 Tax=Desulfonatronospira thiodismutans ASO3-1 RepID=C0GSN3_9DELT Length = 399 Score = 270 bits (690), Expect = 1e-70, Method: Composition-based stats. Identities = 91/375 (24%), Positives = 170/375 (45%), Gaps = 14/375 (3%) Query: 1 MSQQV-IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQ 59 + ++V ++ DTTLR+G+Q LS+++K I L R+G+D +E G ++ Sbjct: 27 LCKKVFMLIDTTLREGDQRYGLYLSLEQKKVIVDGLHRLGLDELETGSVGRDEELETLIK 86 Query: 60 TIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + ++++ + C ++++ A +SL + I + S +HI +L + Sbjct: 87 YARQHHGSTKISLWSPCRIQELEYA-DSL---DPDIISAALPVSDLHIEKRLGLDRCGAL 142 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE 179 + + ED R R A + G + + DT+G P E Sbjct: 143 RLLERTLAGTDKLKAKLSLGLEDFSRADREFALRAALMARDLGVWRVRLSDTLGVMEPGE 202 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 + E++ ++ H H+D G+A N+L A+ G V+ ++ GIGERAG Sbjct: 203 LMEAVRPFREKL----DISLAFHGHNDFGMATANALTALSCGVDYVDVSLLGIGERAGIA 258 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 LEEV+ + K H + Q + S V+ + + I ++A++G F SG+ Sbjct: 259 RLEEVLTFLVYNKG----HAGYDVQSLPELSTCVAGLAGVHINPDRAVLGRQLFHCESGL 314 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 H D + K+ + +E P +G+ + +++L +SG AV+ ++ EMG +L+ L Sbjct: 315 HADALYKSFDLFEPFEPHKMGMQR-RISLGRKSGAGAVRGKLMEMGVNPDFVDLEGLVRD 373 Query: 360 FLKLADKKGQVFDYD 374 + A KG D + Sbjct: 374 VRRAASIKGSPLDDE 388 >UniRef50_C1XGU5 Isopropylmalate/homocitrate/citramalate synthase n=2 Tax=Meiothermus RepID=C1XGU5_MEIRU Length = 422 Score = 269 bits (689), Expect = 1e-70, Method: Composition-based stats. Identities = 103/417 (24%), Positives = 188/417 (45%), Gaps = 32/417 (7%) Query: 2 SQQVIIFDTTLRDGEQAL------QASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDF 55 + ++ I DTT RDG+Q+ + +++EK + L +GV E PV + Sbjct: 17 AHRIEIVDTTFRDGQQSPLLFDTEKYRFTLEEKKVLMTGLLELGVTHFEFFSPVVGVAEA 76 Query: 56 ESVQTIARQV-----KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATK 110 + V+ + K R A RC +DI+ A E+ ++ ++ SP+ Sbjct: 77 QDVRELIAHASALTQKPLRFLAHCRCNLQDIEQALET----GCNGLNLYLGVSPLAQQHN 132 Query: 111 LRSTLDEVIERAIYMVK--RARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINI 168 + +L+E ++ ++ RA + + FS EDA RTP+ D+ R+ +A T+ + Sbjct: 133 AQKSLEESVQLVQEVIATTRAAHPDLYIRFSAEDAFRTPLEDIFRLYDAIYPY-VNTLGM 191 Query: 169 PDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGA 228 PDTVG P + + +++ L +R PN + H H+D GLA+ N +AAV AG R V+ + Sbjct: 192 PDTVGIAEPEDVSAVVAQLRQRYPN---VALECHFHNDRGLALANVIAAVRAGVRYVDAS 248 Query: 229 MNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIV 288 + G+ ER+G S+ V+ + R + N + + + L++ I +P + + Sbjct: 249 IWGLAERSGIPSVTGVLFNLSKRY--PEIAQQYNLSQCYPLNVLMASILGTLVPYTEPVS 306 Query: 289 GSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEM-GYK 347 + H++G+HQ VL ++ YE G+++ QL L SG + + + E+ G+ Sbjct: 307 LTNR-THTAGVHQKAVLNEKKVYEAHNLHDFGVDKNQLLLGPLSGWNLIYYYLKEVEGFV 365 Query: 348 ESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQ-------QEEPEHFRLDYFS 397 S+ + F + G+ + L EE RL+ Sbjct: 366 ISKEQAKQIAQEFKGRTSEIGRRKKPEELLLEIAEAHGLLRHTLPEEVPTARLENLD 422 >UniRef50_A8A943 Pyruvate carboxyltransferase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=A8A943_IGNH4 Length = 488 Score = 268 bits (686), Expect = 3e-70, Method: Composition-based stats. Identities = 91/412 (22%), Positives = 169/412 (41%), Gaps = 35/412 (8%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMG-----VDVMEVGFPVSSPGDF 55 + ++ I DTT RDG+QA + +V++ +++ L +G + E F + + D Sbjct: 60 LPSEIWITDTTFRDGQQA-REPYTVEQIVRLYKYLHELGGPLGKIKTTE--FFLYTEKDK 116 Query: 56 ESVQTIARQV-KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRST 114 E+V+ + K R ++++ + E A + S HI K +++ Sbjct: 117 EAVRRVKELGYKYPIPTGWIRAKKEELSLVKE----AGLEETGILASISDYHIYFKFKAS 172 Query: 115 LDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPI-----ADLARVVEAAINAGATT-INI 168 +V+E+ + +V+ A ED R I + ++++ + G + Sbjct: 173 RGKVVEKYLSVVEEALKMDIIPRVHLEDITRANIFEVVVPFVRKLMKLSERYGLPVKVRY 232 Query: 169 PDTVGYTMPFEFAGIIS------GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGA 222 PDT+G +P A + + V + + H H+D L V N+++A GA Sbjct: 233 PDTLGVGVPIVEAMLPRSIPKLTWVLRHVCGVPSEWLEFHGHNDFHLGVANAVSAWLYGA 292 Query: 223 RQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIP 282 G + GIGERAGN +E ++ A + + +N + I ++ +P Sbjct: 293 GLNNGTLLGIGERAGNVPIEALVFAYA---QLKHGFDGMNTKVITEIAKYYRDELGYEVP 349 Query: 283 ANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMD 342 IVG +GIH DG+LKN E Y E I + + +T +G A + + ++ Sbjct: 350 PYYPIVGRNFAVTRAGIHADGLLKNPETYLPFDTEGILGVKPGVAITPYAGLAGIVYWIN 409 Query: 343 EMGYKESEYNLDN-------LYDAFLKLADKKGQVFDYDLEALAFIGKQQEE 387 + + E + +Y +K + D E LA + K E Sbjct: 410 KTFDLKGEEQVSKKDPKVQAIYKDVMKQFEHGRLTALSDAEMLALVAKHAPE 461 >UniRef50_Q2FZS6 2-isopropylmalate synthase, putative n=51 Tax=Staphylococcus aureus RepID=Q2FZS6_STAA8 Length = 381 Score = 268 bits (685), Expect = 4e-70, Method: Composition-based stats. Identities = 106/391 (27%), Positives = 179/391 (45%), Gaps = 14/391 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + I D T+RDG Q S+ K ++ + ++ ++ +EVG + +F Q Sbjct: 2 IRIQDNTIRDGMQQSNVRKSLIIKKEVLKQINKLNINSVEVGMCTTIEDEFNIHQFRDIL 61 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 + L R EK+I + LK+ + + S +HI KL + I++ Sbjct: 62 SPEKELVVLTRLNEKEIKKIVK-LKI-HNLVVKILLPISDLHIKEKLNFSNKYYIQKIKD 119 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 + + V+ ED RT L +E T+ DTVG + P E+ I Sbjct: 120 CLDILKKDKKGVDICFEDGTRTSREKLKEYMEIISKYQVRTVTFADTVGCSTPLEYGDIF 179 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + ++ NI I S H H+DLGLA N+LAA+ GA+Q+E GIGERAGN +EE+ Sbjct: 180 NYFVKKYSNI---IFSAHCHNDLGLATANTLAAILNGAKQIETTFLGIGERAGNAPIEEI 236 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 I + ++ T ++++TS +S+I + I NK I+G F H SGIHQDG Sbjct: 237 ITILTKKQI---ESTEFTLPDVYKTSINISKILDFQISENKPIIGENIFKHESGIHQDGT 293 Query: 305 LKNRENYEIMTPESIGLNQIQLN---LTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 KN Y+ + P +GL Q+ +++ S + + ++ + + +D + Sbjct: 294 KKNINMYQYLVPSDLGLKNSQVVQFPISNISSKKILHNKFKSI---VNTEEIDENISFYK 350 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPEHFR 392 + +V D L I K++ + +F+ Sbjct: 351 LVNKFSPEVAPEDTVDLLQIIKRRSKDGNFK 381 >UniRef50_B1L5J0 2-isopropylmalate synthase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5J0_KORCO Length = 426 Score = 267 bits (682), Expect = 9e-70, Method: Composition-based stats. Identities = 106/409 (25%), Positives = 174/409 (42%), Gaps = 42/409 (10%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERM----GVDV-MEVGFPVSSPGDFE 56 S ++I DTTLRDG+Q + S +E ++I L + GV +E+ FP +S D E Sbjct: 22 SHDLLITDTTLRDGQQGSR-PFSKEECIKIYSILSELDGGSGVIRDIEL-FPYTSK-DRE 78 Query: 57 SVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 ++ + R +D+ + E + S HI KLR + Sbjct: 79 VIKALRDFGTTPNPIGWIRARIEDLKLVKE----CGLDTTVLLTSVSDYHIHYKLRMSRT 134 Query: 117 EVIERAIYMVKRARNYTDDVEFSCEDAGRTPI--------ADLARVVEAAINAGATTINI 168 E E+ + ++ ++ + ED R+ I D+ R+ E G + I Sbjct: 135 EAREKFLSAIREGLRMGLKLKVAMEDITRSDIYGFVLPFIEDILRISER--EGGEVSFKI 192 Query: 169 PDTVGYTMPFE-------FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAG 221 DT+G +PF +I L E + + I H H+D L V N LAA G Sbjct: 193 SDTLGLALPFPESPLPRGVPRLIRSLIEEM-GLRSEQIEFHGHNDFHLVVANHLAAWLYG 251 Query: 222 ARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPI 281 A + GIGERAGNC LE A+ + L+ +N + + + + S+ I Sbjct: 252 ASISNCTLMGIGERAGNCPLE----AMAIMHSQLSGERKLNLKALSKIIDVFSE-MGFRI 306 Query: 282 PANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRM 341 P I+G AF +GIH DG+LKN Y P IG + ++ SGR+ + + + Sbjct: 307 PEFYPILGENAFKTKAGIHIDGLLKNPAIYLPFDPTIIGRPY-SIEISPYSGRSGIIYWL 365 Query: 342 -DEMGYKE-----SEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQ 384 ++ +E + ++ Y LK+ ++ + EAL+ + K Sbjct: 366 ARKLNIEEWESLKEDPRVELAYREMLKIFEEGRTEPLSEEEALSLLKKY 414 >UniRef50_C9K7B8 Similar to 2-isopropylmalate synthase n=1 Tax=Alternaria alternata RepID=C9K7B8_ALTAL Length = 582 Score = 267 bits (682), Expect = 1e-69, Method: Composition-based stats. Identities = 118/542 (21%), Positives = 217/542 (40%), Gaps = 75/542 (13%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + ++F T LRDG Q+L ++ ++KL + L +G +EV +P ++ +F+ V+ Sbjct: 57 LKTAPVLFSTDLRDGNQSLPNPMTFEQKLSLYKLLVSIGFKEIEVAYPCANQAEFDFVRH 116 Query: 61 IARQV----KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 + ++ + + C E+ I A ES++ A+ + T++ +S + T L+ + D Sbjct: 117 LIETPGLIPEDVLIQVITPCQEETIKRAVESVRGAKQAILFTYLPSSDNYRDTVLKISED 176 Query: 117 EVIERAIYMVKRARNYTDDVE------------FSCEDAGRTPIADLARVVEAAINAGAT 164 + +ERA + AR+ T D E F ED I + R EA Sbjct: 177 DWVERARWGAAYARSITKDSEDPVVRSTRWTFNFGFEDFANARIGAIIRCTEAVRAEWNP 236 Query: 165 ------TINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAV 218 I + +V + P FA I L + N D ++VHTH+D G AV ++ A Sbjct: 237 SKDEKMIIGVASSVEASTPNVFADQIECLSGNISNRDTVRLTVHTHNDRGGAVASAELAS 296 Query: 219 HAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICN 278 AGA ++EG + G GERAGN L V+ A+ + + I+ + ++ I Sbjct: 297 LAGADRIEGCLFGNGERAGNMDL--VVYALNLLTQ--GIEPGIDLSRLDEIRKVYEDITE 352 Query: 279 MPIPANKAIVGSGAFAHSSGIHQDGVLKN--------------------RENYEIMTPES 318 +P+ G+ SG HQD + K R Y + P Sbjct: 353 LPVHPRTPYSGAYYLKAFSGAHQDAISKGLRLRTSATQEGKPCAVWPAWRVPYLPLDPAD 412 Query: 319 IGLNQIQLN-LTSRSGRAAVKHRMD-EMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLE 376 IG + + + S+SG+ V ++ +G A + + G+ D Sbjct: 413 IGRSLDDVVGINSQSGKGGVAWVVNLGLGLDLPPGLARTFSKAVKERSIHFGREMSSDEV 472 Query: 377 ALAFIGKQQEEPEHFRLDYFSVQSGSNDIA--TAAVKLACGEEVKAEAANGNGPVDAVYQ 434 +AF+ + Q + D +Q+ + AA+ G + ++ Sbjct: 473 CMAFLEEYQVLRAADKSDDDMIQAVLRTESPLVAALGQVVG-------------LSSLSA 519 Query: 435 AINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVH 494 +I T + +++ Y+ ++ + GVGL + ++ +A+V Sbjct: 520 SITSHTLAD-DVLSYA-----------AYANVTPEESKPSLWGVGLGVSLQQAKLRAVVS 567 Query: 495 VL 496 L Sbjct: 568 AL 569 >UniRef50_A6FZR1 Homocitrate synthase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6FZR1_9DELT Length = 382 Score = 266 bits (680), Expect = 2e-69, Method: Composition-based stats. Identities = 113/390 (28%), Positives = 181/390 (46%), Gaps = 13/390 (3%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 + D+TLR+G Q+ + KL IA L GVD +EVG PVSS + +A Sbjct: 2 RLVDSTLREGLQSDTRPVDSARKLDIAALLAAFGVDCIEVGNPVSSERARADARRLAGLD 61 Query: 66 KNS-RVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 S RV A RC +DI A ++ ++ FI SP+ L +LDE+IE A+ Sbjct: 62 LGSTRVLAHVRCHPEDIRAAVDT----GVDGLNLFIPCSPLLRHASLGRSLDELIEIAVG 117 Query: 125 MVKRARNYTDDVEF--SCEDAGRTPIADLARVVEAAIN-AGATTINIPDTVGYTMPFEFA 181 ++ AR ++E + ED+ RTP+ +L R A + + + DTVG P Sbjct: 118 ALELARALRPELELRITPEDSFRTPVPELERFCGAVTSRVRVDRVGLADTVGVAHPRAVE 177 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 + L +R + H H+D G AV N+L A AGA V+ + G+GER G +L Sbjct: 178 ARFARLRQRF----DLDLEFHGHNDTGCAVANALLAREAGATHVDVTVLGLGERNGITAL 233 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 E + A+ V D VH + + + ++ V+ + IP N +VG+ +FAH +G+H Sbjct: 234 EGFVAALLVH-DPDAVHGRLRLELLPLLTRAVADAFGVEIPRNSCLVGANSFAHKAGVHT 292 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 + +L++R +YE + P+ +G+ + L +G + + R +G S L L + Sbjct: 293 NAMLRDRRSYEFVDPQLMGVERRLLAGHEMTGASVLGARAQALGLDLSPEQLRRLAASVR 352 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPEHF 391 A + E L E + Sbjct: 353 TSASHGALASETIDELLLASVCAPERAQGL 382 >UniRef50_Q3IV11 Isopropylmalate/homocitrate synthase n=1 Tax=Rhodobacter sphaeroides 2.4.1 RepID=Q3IV11_RHOS4 Length = 336 Score = 266 bits (679), Expect = 2e-69, Method: Composition-based stats. Identities = 96/313 (30%), Positives = 159/313 (50%), Gaps = 12/313 (3%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 ++ +I D TLR+G QA SV + + IA AL+ +GVD++E+G P++ P + + + +A Sbjct: 4 KRTLINDATLREGNQASGVRFSVHDSVAIATALDGIGVDMIEIGHPLAGPYEHQRTEAVA 63 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIAT-KLRSTLDEVIER 121 + +++ A AR DI+ + + A + F+ + + + + E+I Sbjct: 64 KLGLGAKIIAHARAHRTDIEAVSRT----GATWVGIFLGVNDITTKARVIGRSTTELIRM 119 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 VK A++ ++ +SCEDA RT L V AAI+AGA I DT+G P E A Sbjct: 120 VADAVKVAKDCGLNIRYSCEDASRTNTLFLVDVFGAAIDAGADRICYADTLGIAEPAEVA 179 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 ++ + P+ + + VH HDD GLA+ NSLAA+ AG + ++N +GER G L Sbjct: 180 RKVTLMKSEFPDAE---VEVHLHDDRGLAMANSLAAIDAGVDSISVSVNALGERCGITDL 236 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 +++ + R + + E+ S+LV+ N P A + IVG AF H S +HQ Sbjct: 237 ATLLVNLGFRGERALP----DISELRALSRLVAMSSNTPFDALRPIVGDNAFKHGSKLHQ 292 Query: 302 DGVLKNRENYEIM 314 Y+ + Sbjct: 293 RATQYEPRAYDWI 305 >UniRef50_B8DR73 Pyruvate carboxyltransferase n=3 Tax=Desulfovibrio vulgaris RepID=B8DR73_DESVM Length = 455 Score = 266 bits (679), Expect = 2e-69, Method: Composition-based stats. Identities = 104/395 (26%), Positives = 172/395 (43%), Gaps = 24/395 (6%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI-ARQ 64 ++ DTTLR+GEQ+ LS+ ++ ++ L +GV EVG+ + D + + AR Sbjct: 1 MLLDTTLREGEQSFGTYLSMADRERVLRGLAAVGVPEAEVGW--AGREDLTDMLALSARV 58 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 A RC D+ A A R+ + S H+A +L +++ Sbjct: 59 APGLAAAAWCRCRPGDLRAAV----ACGASRVCVGVPVSDAHLARRLGLGRAALLDLLAA 114 Query: 125 MVKRARNYTDD-VEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 + AR + V EDA R A + V A GA + + DTVG P E A + Sbjct: 115 TLAEARMLGIEHVTVGMEDASRADRAFVFAVACHAAAHGAHRVRLSDTVGLYTPLEVADV 174 Query: 184 ISGLYERV---------PNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 + L + P + I H H+D G+A N+L A+ GA + ++ G+GE Sbjct: 175 VRALRAELEGARQDDTAPRARRVSIGTHFHNDCGMATANALTALECGADCADVSVLGLGE 234 Query: 235 RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFA 294 RAG LEE+ A+ VR + V+Q ++ +P + + G FA Sbjct: 235 RAGVARLEELAAALVVRG-----RARFELAPLRALCGQVAQAASLSVPRHWPVAGRDIFA 289 Query: 295 HSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLD 354 SG+H GV ++ +E PE +G ++ ++ + +SG AAV + E+ L Sbjct: 290 VESGLHAHGVRRDPSLFEPFPPELVGDSR-RMGVGRKSGVAAVAAALAELSILPPPDELP 348 Query: 355 NLYDAFLKL-ADKKGQVFDYDLEALAFIGKQQEEP 388 + +A L A + + +L +A +GK P Sbjct: 349 AIVEAVRDLSATLRRPLTPAELAEVAGLGKHHAPP 383 >UniRef50_B8J227 Pyruvate carboxyltransferase n=2 Tax=Desulfovibrio RepID=B8J227_DESDA Length = 611 Score = 264 bits (676), Expect = 4e-69, Method: Composition-based stats. Identities = 104/455 (22%), Positives = 193/455 (42%), Gaps = 33/455 (7%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDV--MEVG-FPVSSPGDFESV 58 ++Q+ I DTT RDG+QA + +VK+ ++ L R+G + F + S D + + Sbjct: 49 AEQMRITDTTFRDGQQA-RPPYTVKQVAKMFDFLHRLGGKTGLITASEFFLYSAKDRKCI 107 Query: 59 QTI-ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 AR + RV A R D+ +A + E + S HI KL T + Sbjct: 108 DVCRARGYRFPRVTAWIRATRDDLKLARD----MEFDETGMLTSVSDYHIFLKLGKTRQQ 163 Query: 118 VIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLA-----RVVEAAINAGATT-INIPDT 171 ++ + M ++A + ED R I R++E + +G I + DT Sbjct: 164 AMDMYVGMAEQALEWGIIPRCHFEDITRADIYGFCLPLAQRLMELSRQSGMPVKIRLCDT 223 Query: 172 VGYTMPFEFAGIISGLYERVP------NIDKAIISVHTHDDLGLAVGNSLAAVHAGARQV 225 +GY +P+ A + + V + + H H+D + N + A G V Sbjct: 224 MGYGVPYPGAALPRSVQRIVRAFTDEAGVPGQWLEWHGHNDFHKVLVNGVTAWLNGCGAV 283 Query: 226 EGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANK 285 + G GER GN LE + + + A + + +Q + + IP N Sbjct: 284 NSTLFGFGERTGNTPLEAL---LVEYISLTGDDAAADTTVLHEVAQFFEKELDYRIPHNY 340 Query: 286 AIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMG 345 VG A S+G+H DG+ KN E Y I + + + + +T ++GRA V + ++ Sbjct: 341 PFVGRDFNATSAGVHADGLAKNEEIYNIFDTKHLLGRSVPIIITDKTGRAGVAYWINTNL 400 Query: 346 YKESEYNLD-------NLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSV 398 E E + +YDA + + ++ G+ ++ + + Q+ PE F ++ ++ Sbjct: 401 NLEKERQISKKHPAVGKIYDAIMAVYEETGRTTNFSHVEMEALV-QRFMPELFVSEFDNM 459 Query: 399 QSGSNDI-ATAAVKLACGEEVKAEAANGNGPVDAV 432 + + ++ A V+LA +++ + +DA Sbjct: 460 KQLAGELAANLLVRLARDKDLLDFGEKAHAKIDAF 494 >UniRef50_D2JWV4 Putative homocitrate synthase n=1 Tax=Filobasidiella depauperata RepID=D2JWV4_9TREE Length = 465 Score = 264 bits (675), Expect = 5e-69, Method: Composition-based stats. Identities = 87/389 (22%), Positives = 152/389 (39%), Gaps = 57/389 (14%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 I ++TLR+GEQ A +++ K++IA L+ GV+ +E+ P +SP + I + Sbjct: 68 KIIESTLREGEQFANAFFNLETKIKIAKMLDEFGVEYIELTSPAASPESRAHCEAICKLG 127 Query: 66 -KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 K +++ RC D +A E+ + I TS + + + + Sbjct: 128 LKKTKILTHIRCHMDDARLAVET----GVDGVDVVIGTSSFLREHSHGKDMAWITKTTVD 183 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 G + + DTVG P + ++ Sbjct: 184 -----------------------------------KIGVNRVGVADTVGCADPRQVYDLV 208 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLA-----------VGNSLAAVHAGARQVEGAMNGIG 233 L + I H H+D G + N+ AA+ AGA V+ ++ GIG Sbjct: 209 RTLR----GVVSCDIETHFHNDTGCGKASTLDESTAPIANAYAALEAGATHVDTSILGIG 264 Query: 234 ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAF 293 ER G L +I + V D V + N + V++ + +P N I G AF Sbjct: 265 ERNGITPLGGLIARMMV-ADPDYVKSKYNLTMLRELENTVAEAVEVQVPFNNYITGFCAF 323 Query: 294 AHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNL 353 H +GIH +L N YEI+ P G+ + +G AVK R++++ ++ + Sbjct: 324 THKAGIHAKAILANPSTYEILNPADFGMTRYVSIGHRLTGWNAVKSRVEQLNLNLTDEQV 383 Query: 354 DNLYDAFLKLAD-KKGQVFDYDLEALAFI 381 + +LAD + + D D+ + Sbjct: 384 KDATAKIKELADVRTQSMEDVDMILRIYH 412 >UniRef50_C5AK37 Isopropylmalate/homocitrate/citramalate synthase n=7 Tax=Proteobacteria RepID=C5AK37_BURGB Length = 456 Score = 263 bits (672), Expect = 2e-68, Method: Composition-based stats. Identities = 98/320 (30%), Positives = 158/320 (49%), Gaps = 13/320 (4%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I D +LR+G Q +Q + +++ +A + GVD++E G P SP + E V+ + R V Sbjct: 5 IIDCSLREGCQTIQCNFDIEQSEILARKIAEFGVDMIECGHPKISPYELERVRAVVR-VS 63 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLR-STLDEVIERAIYM 125 V A ARC +DID AES A + F + +P+ +ATK D+V+ Sbjct: 64 PLPVLAHARCRSEDIDAVAES----GAAWVGMFASFNPVSLATKFGGMGKDQVLALFEAS 119 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 ++ A++ V + EDAGRT +DL R+ + A+ AGA I D+VG +P E I++ Sbjct: 120 IRYAKSRGLSVRATIEDAGRTEQSDLFRIYQTAVAAGADRICFADSVGALLPSETYDILA 179 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245 L + H H+D GLA+ +SL A+ AG + + NGIGERAG ++ Sbjct: 180 LLRH---EFRQVQFEYHVHNDRGLALASSLEALRAGVEWISTSCNGIGERAGVTDTFQLA 236 Query: 246 MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVL 305 ++ R + + + S+LV + + IVG FAH+S +H+ Sbjct: 237 ALLESRFG----DASRRLDKARQLSELVRVFSRIDGSPMQPIVGDNVFAHASRLHRIACE 292 Query: 306 KNRENYEIMTPESIGLNQIQ 325 K+ Y I +P G +++ Sbjct: 293 KDASAYNIHSPALAGDAEVR 312 >UniRef50_A8TLL5 Homocitrate synthase n=1 Tax=alpha proteobacterium BAL199 RepID=A8TLL5_9PROT Length = 385 Score = 259 bits (662), Expect = 2e-67, Method: Composition-based stats. Identities = 113/394 (28%), Positives = 173/394 (43%), Gaps = 13/394 (3%) Query: 1 MS-QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQ 59 M V+I D+TLR+GEQ + A S KL+IA AL GV+ +EV P +S Sbjct: 1 MPLSDVVIVDSTLREGEQFVHADFSRDAKLEIARALTSFGVNYLEVTSPAASRRSRTDAA 60 Query: 60 TIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 TIA + V A RC + D +A ++ A +H +ATSP+ A + EV+ Sbjct: 61 TIANAGLPAMVAAHIRCHKDDAAIAIDTGVGA----LHMVMATSPILRAASHGKAIAEVV 116 Query: 120 ERAIYMVKRARNYTDDVE--FSCEDAGRTPIADLARVVEAAINA-GATTINIPDTVGYTM 176 A + + RN ++E FS EDA R P+ DL V + DT G Sbjct: 117 RIAAEVGEFVRNRAPNIELRFSSEDAFRCPLNDLMNVYLPLSELRLFDRFGLADTTGAAT 176 Query: 177 PFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERA 236 P A +++ L + I H H+D+G A+ N+ AA GA + + G+GER Sbjct: 177 PDRVAEVVNLLRR----LTTTPIEFHGHNDIGCAIANAHAAAMNGATHINTTVLGLGERN 232 Query: 237 GNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHS 296 G LE +I A+ D E+ + V+++ + +P N+ +VG AF+H Sbjct: 233 GITPLEGLI-AVMYAADRGRTMAQFQLSELPALCRRVAELAGVAVPFNQVLVGESAFSHK 291 Query: 297 SGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNL 356 +G+H V + +YE M P GL + +G AV+ R D +G + + +L Sbjct: 292 AGMHTKAVHNDPRSYEAMDPSDFGLTREIAISHRLTGWNAVRVRADALGLRLALADLKEA 351 Query: 357 YDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEH 390 AD+ D L + H Sbjct: 352 TSRVKSAADEHTLSLDDVDRILTDVAALATARPH 385 >UniRef50_A9HXK1 2-isopropylmalate synthase (Fragment) n=1 Tax=Roseobacter litoralis Och 149 RepID=A9HXK1_9RHOB Length = 250 Score = 258 bits (659), Expect = 4e-67, Method: Composition-based stats. Identities = 100/244 (40%), Positives = 147/244 (60%) Query: 257 VHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTP 316 ++T IN + S +VS++ MP+ NKAI+G AFAHSSGIHQDG LK+RENYEIM P Sbjct: 7 LNTNINAKHFSDISNMVSRMMRMPVQPNKAIIGQNAFAHSSGIHQDGFLKHRENYEIMNP 66 Query: 317 ESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLE 376 E +G+N + LT+RSGR A+KH ++ +GY+ NLD +Y+ FL LAD+K + D D+ Sbjct: 67 EDVGINSADIILTARSGRHALKHHLERLGYEIERLNLDQVYERFLILADEKKAISDDDIH 126 Query: 377 ALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAI 436 +L GK+ ++L V G TA++KL K A+GNGPV+A AI Sbjct: 127 SLMSDGKEDSYKNGYKLTLLQVLCGDPLSPTASIKLEHNGVEKEAMASGNGPVNATINAI 186 Query: 437 NRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVL 496 I ++EL ++++ A G D + +V+I G+ + G G +TDIV++SA A + + Sbjct: 187 QSIVGADIELKEFTIQAVNGGSDDVSKVNIRIASEGKSYVGHGFSTDIVKASAYAYLDAM 246 Query: 497 NNIW 500 N Sbjct: 247 NKFM 250 >UniRef50_Q7X1M2 Homocitrate synthase (Fragment) n=1 Tax=Leptospirillum ferrooxidans RepID=Q7X1M2_9BACT Length = 304 Score = 258 bits (659), Expect = 4e-67, Method: Composition-based stats. Identities = 87/295 (29%), Positives = 133/295 (45%), Gaps = 11/295 (3%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 + DTT+RDG Q+ K+ I L R+GV +EVG P + E ++ + Sbjct: 19 VFVDTTIRDGGQSPGVFFDRPTKMVIVTTLSRIGVQEIEVGTPCLGDHEIEDLRALLSLP 78 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 + R +E D ES R+H TS H A+ +++ER Sbjct: 79 VPVELFPWLRPLEAD----FESALGLGFKRVHVSFPTSDAHRASVQNMGRPDIVERVRKT 134 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 V R V EDA R P+ L + A +G + DTVG P E IS Sbjct: 135 VLRMTGEGCRVSIGLEDASRAPMDFLKEFIAAVRESGGIRVRYCDTVGKHHPAEIIERIS 194 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245 L + + I +H H+DLG+A N+++A H+GAR + + G+GERAGN ++EEV Sbjct: 195 ELSK-----EGLPIEIHCHNDLGMATANTVSACHSGARYLSTTVTGVGERAGNAAMEEVA 249 Query: 246 MAIKVRKDILNV--HTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSG 298 A+ + ++ +AI+ + S+ + + + IVGS F HSSG Sbjct: 250 FALACERGDPSLPESSAIDLPGLAHISRWLYGAIRRTLSPYRPIVGSRIFHHSSG 304 >UniRef50_Q1DCT2 2-isopropylmalate synthase/homocitrate synthase family protein n=3 Tax=Myxococcales RepID=Q1DCT2_MYXXD Length = 421 Score = 254 bits (650), Expect = 4e-66, Method: Composition-based stats. Identities = 105/378 (27%), Positives = 172/378 (45%), Gaps = 27/378 (7%) Query: 5 VIIFDTTLRDGEQALQA-SLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 V I D TLRDG QA S +V+EK + ++ +GV + +G P + P E V T+AR Sbjct: 30 VEINDETLRDGMQATAVTSPTVEEKRGLLELMQHIGVSAVSLGMPAAGPWALEEVVTLAR 89 Query: 64 QVKNSRVC----ALARCVEKDIDVAAESLKVAEAF-RIHTFIATSPMHIATKLRSTLDEV 118 ++ + AR + DI E+++ A +HTFI +SP+ + LD + Sbjct: 90 HIREEALRLEPNCAARTLHSDIVPIVEAVQRAGQPIVVHTFIGSSPLRQCAEA-WDLDFI 148 Query: 119 IERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 + + + A +V F ED R+ L + AA+ GA+ + + DTVG+ P Sbjct: 149 LRSSTAAIDFAVRQGLEVAFITEDTTRSTPETLELLFRAAVEHGASRLVLCDTVGHATPA 208 Query: 179 EFAGIISGLYERVPNIDK-AIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 ++ + V + + H H+D GLA+ N+L A+ AGA +V G GIGER G Sbjct: 209 GTRALVRWTRDLVERLGSPVKVEWHGHNDRGLALINALVALEAGATRVHGCGLGIGERTG 268 Query: 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLV---SQICNMPIPANKAIVGSGAFA 294 N +E + Q++ R V +Q+C +PIP N +VG AF Sbjct: 269 NAPVEL--------LLLNLKLLGWIDQDLTRLVDYVLTLAQVCRVPIPRNYPLVGEDAFR 320 Query: 295 HSSGIHQDGVLKNRENYEIMTPESI--------GLNQIQLNLTSRSGRAAVKHRMDEMGY 346 ++G+H ++K E + + I + QL L SG + V++ + G Sbjct: 321 TATGVHSAAIIKALERGDDWLADHIYSSVPAGEFGRRQQLELGPMSGMSGVRYWLMVRGL 380 Query: 347 KESEYNLDNLYDAFLKLA 364 +E+E + + A Sbjct: 381 QENEQLCEEILRRAKSAA 398 >UniRef50_C7GH85 2-isopropylmalate synthase n=3 Tax=Roseburia RepID=C7GH85_9FIRM Length = 443 Score = 254 bits (648), Expect = 9e-66, Method: Composition-based stats. Identities = 90/368 (24%), Positives = 151/368 (41%), Gaps = 27/368 (7%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVD---VMEVGFPVSSPGDFES 57 M + + I DTT RDG+Q+ +A + ++ + I L R+G + + F + S D ++ Sbjct: 86 MPENIWITDTTFRDGQQS-RAPYTTEQIVTIYDYLHRLGGPKGLIRQSEFFLYSKKDRDA 144 Query: 58 V-QTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 V + + R K V + R ++D + +K ++ S HI K++ T Sbjct: 145 VYKCLERGYKFPEVTSWIRASKQDFQL----VKDIGLRETGILVSCSDYHIFYKMKMTRR 200 Query: 117 EVIERAIYMVKRARNYTDDVEFSCEDAGRTPIA-----DLARVVEAAINAGATT-INIPD 170 EV+ + +++ ED R+ I +++ I D Sbjct: 201 EVMNLYLSVIRECLETGISPRCHLEDITRSDIYGFVIPFCVELMKLMDEYKIPIKIRACD 260 Query: 171 TVGYTM-------PFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGAR 223 T+GY + P GII GL + +I H H+D AV NS A GA Sbjct: 261 TMGYGVNFPGAVIPRSVPGIIYGLTTHA-GVPSELIEWHGHNDFYKAVNNSTTAWLYGAS 319 Query: 224 QVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 V ++ GIGER GN LE ++ K L+ ++ I ++ + P+ Sbjct: 320 GVNCSLFGIGERTGNTPLEAMVFEYAQLKGTLD---GMDTTVITELAEYFEKELGYVQPS 376 Query: 284 NKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDE 343 VGS +GIH DG+LKN E Y I Q +++ + R+ +D+ Sbjct: 377 RTPFVGSNFNVTRAGIHADGLLKNEEIYNIFDTGKF-FKQTTISICFQHIRSCRNRSLDQ 435 Query: 344 MGYKESEY 351 + SE Sbjct: 436 LLLPSSER 443 >UniRef50_D1J0N9 Whole genome shotgun sequence of line PN40024, scaffold_124.assembly12x (Fragment) n=1 Tax=Vitis vinifera RepID=D1J0N9_VITVI Length = 974 Score = 252 bits (645), Expect = 2e-65, Method: Composition-based stats. Identities = 101/288 (35%), Positives = 160/288 (55%), Gaps = 23/288 (7%) Query: 241 LEEVIMAIKVRKD--ILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSG 298 V+MA+K R + + ++T IN + I +TS++V++ + + +KAIVG+ AFAH SG Sbjct: 677 TYMVVMALKCRGEKALGGLYTGINIRHIVKTSKMVAEYSGLQVQPHKAIVGANAFAHESG 736 Query: 299 IHQDGVLKNRENYEIMTPESIGL---NQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDN 355 IHQDG+LK++E YEI++PE IGL N+ + L SGR A+K R+ E+GY+ LD+ Sbjct: 737 IHQDGMLKHKETYEIISPEDIGLFRSNESGIVLGKLSGRHALKSRLLELGYEIEGMELDD 796 Query: 356 LYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHF-RLDYFSVQSGSNDIATAAVKLAC 414 ++ F ++A+KK + D D+ AL + + +P+ F +L V G+ ++TA VKL Sbjct: 797 IFWRFKEVAEKKKNLTDVDVIAL--VSDEIFQPKVFWKLGDLQVTCGTLGLSTATVKLID 854 Query: 415 GEEVKAEAAN-GNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNG- 472 + K A + G GPVD+ Y+AI+ + + V L++Y L A G DA+ ++ Sbjct: 855 ADGQKHVACSVGTGPVDSAYKAIDLLVKEQVTLLEYGLNAVTEGIDAIATTRVLIRGEKN 914 Query: 473 -------------RRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEK 507 R F G G DIV SS +A + LN + + K Sbjct: 915 HTLTNALTGETVHRSFSGTGAGMDIVVSSVRAYISALNKMLGFKDQSK 962 Score = 236 bits (602), Expect = 2e-60, Method: Composition-based stats. Identities = 110/262 (41%), Positives = 151/262 (57%), Gaps = 37/262 (14%) Query: 23 LSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSR--------VCALA 74 ++ KEKL IA L ++GVD++E GFP +S D ++V+ IA++V N+ +C LA Sbjct: 1 MTSKEKLDIARQLAKLGVDIIEAGFPAASKDDLDAVKIIAKEVGNAVDENGHVPVICGLA 60 Query: 75 RCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYT- 133 RC DI A E+ KL+ + EVIE A MVK AR+ Sbjct: 61 RCNRNDISTAWEA---------------------YKLKKSEKEVIEIAREMVKYARSLGC 99 Query: 134 DDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPN 193 DDVEFS EDAGR+ L +++ I AGATT+NIPDTVGYT+P EF +I+ + P Sbjct: 100 DDVEFSPEDAGRSEREFLYKILGEVIKAGATTLNIPDTVGYTVPNEFGQLIADIKSNTPG 159 Query: 194 IDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKD 253 I+ IIS H +DLGL+ N++A AGARQVE +NGIGERAGN SLEEV + ++ Sbjct: 160 IENVIISTHCQNDLGLSTANTIAGACAGARQVEVTINGIGERAGNASLEEVCLIYRLAPG 219 Query: 254 ILN-------VHTAINHQEIWR 268 + ++ ++N IWR Sbjct: 220 LCTDTQLNGVINLSMNLSGIWR 241 >UniRef50_B4B8D2 Pyruvate carboxyltransferase n=1 Tax=Cyanothece sp. PCC 7822 RepID=B4B8D2_9CHRO Length = 277 Score = 252 bits (645), Expect = 2e-65, Method: Composition-based stats. Identities = 116/277 (41%), Positives = 170/277 (61%), Gaps = 6/277 (2%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +S+Q++I DTT+RDGE +S EKL++A LE VD++EV +P S DF+ + Sbjct: 4 LSEQILILDTTMRDGELVPGIKMSQAEKLRLAQLLEEAKVDIIEVSYPAKSQQDFDEIVA 63 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 ++R++KNS VCAL+ ++I+ AA LK A RIH + S +++A K E + Sbjct: 64 VSREIKNSIVCALSNLSVQEIERAATGLKSASRGRIHLY---SNVNLAKKEPLKRQEALS 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 V ARNY DD+E+S DA R+ + L R +E AIN+GA TINIPD++G +P EF Sbjct: 121 MIQQGVTLARNYCDDIEWSAFDASRSDLDFLCRGIEMAINSGAKTINIPDSLGVLLPAEF 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 A ++ ++ RVPNIDK+I+SVH HDD A+ NSL A+ G RQ+E ++NG+G R GN + Sbjct: 181 AQLLEKIFTRVPNIDKSIVSVHCHDDCEQALLNSLIALEVGVRQIECSLNGLGARKGNAN 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQIC 277 L+ VI I T++ ++I +LV QI Sbjct: 241 LKSVIKEID---QNPTYKTSVILEKIPPAEELVKQIS 274 >UniRef50_B1I1Z4 Pyruvate carboxyltransferase n=1 Tax=Candidatus Desulforudis audaxviator MP104C RepID=B1I1Z4_DESAP Length = 301 Score = 252 bits (644), Expect = 3e-65, Method: Composition-based stats. Identities = 82/266 (30%), Positives = 124/266 (46%), Gaps = 9/266 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M QV + DTTLRDGEQ S +EK+ +A AL+R+GV+++E G P + ++V+ Sbjct: 1 MP-QVFLVDTTLRDGEQTPGLVFSTEEKVAVASALDRLGVELIEAGIPAMGVDEQKAVRA 59 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 + +RV A R DI+ + A + S +H+ KL T ++ Sbjct: 60 VLGAGLRARVLAWNRAHPSDIEASL----ACGATCLQISFPVSDIHLQHKLGRTRSWLLA 115 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 R ++ A +V EDA R A L + A AGA + DTVG PF Sbjct: 116 RLEEVMALAVAPGREVAVGAEDASRADPAFLRLFAKKAEEAGACRLRYCDTVGVLDPFRS 175 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 +S L ++ + H H+D G+A N+LAAV GA ++ +NG+GERAGN S Sbjct: 176 RDAVSDLTHKL----NIPLEFHAHNDFGMATANTLAAVKGGAAYLDVTVNGLGERAGNAS 231 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEI 266 L V ++ + V + Sbjct: 232 LSAVARGLRQFYGMEVVREETELAML 257 >UniRef50_B2KBD6 Pyruvate carboxyltransferase n=7 Tax=Bacteria RepID=B2KBD6_ELUMP Length = 416 Score = 250 bits (640), Expect = 7e-65, Method: Composition-based stats. Identities = 105/382 (27%), Positives = 172/382 (45%), Gaps = 30/382 (7%) Query: 1 MSQQ-VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPG--DFES 57 MS + + I D T RDG Q + L+ +K + + L+ MG+ E GFP + + Sbjct: 1 MSDKLIYIVDVTNRDGVQTSRLGLAKLQKTLVNIYLDEMGITQSEFGFPTTQHEINYLNA 60 Query: 58 VQTIARQ--VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKL--RS 113 +A + +K + + R +E D+ +A + V + ++ I+TS I K R Sbjct: 61 NLDLAERGGIKKTVLSGWMRALESDVVLAFK--NVPKLKTVNLSISTSDQMIQGKFGGRK 118 Query: 114 TLDEVIERAIYMVKRARNYTDD-VEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTV 172 T ++I + VK+A + V + EDA RT L AA AGA + DT+ Sbjct: 119 TRKDIINQMTAAVKKAYECGAELVGVNSEDASRTDQEYLVEFALAAKAAGAKRLRYCDTL 178 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGAR-----QVEG 227 GY P ++ L +R + +H H+DLG+AV NS+ + Sbjct: 179 GYDSPDVAYSRLNDLAKRTC----LDLEMHFHNDLGMAVANSVRGAQGAIDGGVNAYINT 234 Query: 228 AMNGIGERAGNCSLEEVIMAIKVRKDI---LNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 A+NG+GER+GN L ++A+ + I+ +IW ++ S +PIP N Sbjct: 235 AVNGMGERSGNADLACCVLAVLKSSGFSGKYKIDPDIDMSKIWPLAKYTSYSFGVPIPIN 294 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQ-------LNLTSRSGRAAV 337 VG AFAH SGIH DG LK+R NYE+ E +G + + + G Sbjct: 295 YPAVGGNAFAHESGIHADGALKDRRNYELYDYEELGRGEPEVIETGRMITTGEYGGIKGF 354 Query: 338 KHRMDEMGYK-ESEYNLDNLYD 358 + +++ + + E N+ + Sbjct: 355 RDVYEKLSIEFKDEKEARNILE 376 >UniRef50_B5HTY3 2-isopropylmalate synthase n=1 Tax=Streptomyces sviceus ATCC 29083 RepID=B5HTY3_9ACTO Length = 593 Score = 250 bits (639), Expect = 8e-65, Method: Composition-based stats. Identities = 114/530 (21%), Positives = 192/530 (36%), Gaps = 68/530 (12%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 + LRDG QAL + ++ K ++ L R+G +E+G+P +S +FE V+ + Sbjct: 73 LWSSVDLRDGNQALANPMDLRRKRKMFDLLVRLGFKDIEIGYPSASETEFEFVRHLITGG 132 Query: 66 ---KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 + V + + ID E+++ + +H AT+ + R T EV+ A Sbjct: 133 HIPDDVTVTVFTPAIPELIDRTFEAVRGTDRAVVHLCHATACLWREVVFRKTPSEVMALA 192 Query: 123 IYMVKRARNYTDD------VEFSCEDAGRTPIADLARVVEAAINAG------ATTINIPD 170 +R D E+S E T + T+N+P Sbjct: 193 QESAQRLVRLADRADGAIRFEYSPETFNVTEPQFALEIANTVAEIVEATPERPLTLNLPS 252 Query: 171 TVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMN 230 TV P FA I + + D I+SVH H+D G AV + A+ AGA +VEG + Sbjct: 253 TVEMHAPTVFADQIEWMSRNLDRRDGIILSVHPHNDRGTAVAAAEFALAAGADRVEGTLF 312 Query: 231 GIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGS 290 G GER GN L + + + R V ++ +I + + MP+P G Sbjct: 313 GNGERTGNVCLITLALNLFSRG----VDPQLDLSDIPSVRRAAEECNRMPVPDRHPYAGD 368 Query: 291 GAFAHSSGIHQDGVLKNRE--------------------NYEIMTPESIGLN-QIQLNLT 329 F SG HQD + K Y + P+ +G + + + + Sbjct: 369 LVFTAFSGTHQDAIAKGLLHLEDQAAAAGVPAAELPWDVPYLPVDPQDLGRSYEAVIRVN 428 Query: 330 SRSGRAAVKHRMDEM-GYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEP 388 S+SG+ + H + G + ++ D G D Sbjct: 429 SQSGKGGIAHVLRTRWGIELPVALRAEFARVVQRVTDLSGTEVDPGRIW----------- 477 Query: 389 EHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVK 448 + FR +Y + A A+ + A A G VDA + + R Sbjct: 478 DVFRAEYCDAGDWAGFTAPASGDDPAEALLAAARAYG---VDAHVEQLVRDEG------- 527 Query: 449 YSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNN 498 G G + + + G GL E++ +A++ L+ Sbjct: 528 ----GPGSGARHVCYAQLFVAHE--PVWGAGLGATAGEATVRAVLSALHR 571 >UniRef50_C7IGD9 Homocitrate synthase n=1 Tax=Clostridium papyrosolvens DSM 2782 RepID=C7IGD9_9CLOT Length = 274 Score = 249 bits (637), Expect = 2e-64, Method: Composition-based stats. Identities = 78/260 (30%), Positives = 120/260 (46%), Gaps = 8/260 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M ++ I DTTLRDGEQ + S +K+++A ++ G+ +E G P + E++ Sbjct: 1 MKEKKYIIDTTLRDGEQTPGYAFSKAQKVELAKVMDDAGIYQIEAGIPAMGNYEKETISE 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I Q KN+ + R DI+ + + IH S +HI +KL + Sbjct: 61 IMSQRKNALISTWNRMSRDDINNSFD----CHPDIIHITAPISYIHIYSKLNKNKKWLRN 116 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 V A++ +V EDA R I + + + G ++ DTVG P Sbjct: 117 TLQECVFMAKDKGYEVTVGFEDASRADITFIISMANLLADMGVKSVRFADTVGVLTPART 176 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 I + E V + +H H+DLG+A+ NSL A AGA ++ + GIGERAGNC Sbjct: 177 YQCIREIKENV----DIPVGIHAHNDLGMALANSLIAAKAGALYIDTTIGGIGERAGNCD 232 Query: 241 LEEVIMAIKVRKDILNVHTA 260 L + I+A +I HT Sbjct: 233 LYQFILAAGGIFNIKPEHTD 252 >UniRef50_A4QUQ8 Putative uncharacterized protein n=1 Tax=Magnaporthe grisea RepID=A4QUQ8_MAGGR Length = 633 Score = 246 bits (629), Expect = 1e-63, Method: Composition-based stats. Identities = 94/446 (21%), Positives = 169/446 (37%), Gaps = 46/446 (10%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +++ I T LRDG Q+L A L+ +K + L +G +EV FP +S +FE + Sbjct: 10 ITKAPIWLSTDLRDGNQSLTAPLNSDQKFEFFKLLVEIGYKEIEVSFPAASNVEFEFTRR 69 Query: 61 IARQV----KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 + + R+ ALA + ++L+ A+ + T+I S + + + Sbjct: 70 LVETPGAVPDDVRLRALAPTRNDFLKRTVDALEGAKRATVCTYICVSDKMLKYQ-GFSRA 128 Query: 117 EVIERAIYMVKRARNYTDD---------VEFSCEDAGRTPIADLARVVEA---AINAGAT 164 IE+A+ V+ R+ T D + F E + + EA A A A Sbjct: 129 RAIEQAVGAVRYLRSITKDNPDTKTRWDLAFGLESYNESDQDFALAMTEAVMGAWEASAD 188 Query: 165 ---TINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAG 221 + + + P FA + + + +IS+HTH D G + + AG Sbjct: 189 DQMWVVLATSTEVATPNVFADQVETFIAGLSAPENVLISIHTHSDRGCGAAAAELGMLAG 248 Query: 222 ARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPI 281 A VEG + G GERAGN L + + + R + ++ +++ Q+ + + Sbjct: 249 AHMVEGCLFGNGERAGNVDLVTLALNLYTRG----ISPHLDFSDLYAVRDRYEQLTGLQV 304 Query: 282 PANKAIVGSGAFAHSSGIHQDGVLKNREN-----------------YEIMTPESIGLN-Q 323 A G A SG HQ+ + K Y + P+ +G+ Sbjct: 305 TARTPYAGEYALQAFSGHHQNIIRKGMGLRLRAEAEGRPAPVWDIPYLPVDPQDLGIPID 364 Query: 324 IQLNLTSRSGRAAVKHRMDEM-GYKESEYNLDNLYDAFLKLADKKGQVFDYDLEA---LA 379 + + S+SG+AA + G + + L + + D + Sbjct: 365 HIIRVNSQSGKAAATWILSRRWGLDLPVDMQVHFGRRLMALCEALAREISQDELLGLFTS 424 Query: 380 FIGKQQEEPEHFRLDYFSVQSGSNDI 405 G + + L + +VQ SN Sbjct: 425 TYGLETPDRPSHHLGHLTVQRSSNGR 450 >UniRef50_A5N6T4 2-isopropylmalate synthase-related protein n=2 Tax=Clostridium kluyveri RepID=A5N6T4_CLOK5 Length = 453 Score = 246 bits (629), Expect = 1e-63, Method: Composition-based stats. Identities = 84/390 (21%), Positives = 155/390 (39%), Gaps = 29/390 (7%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERM----GVDVMEVGFPVSSPGDFE 56 + + I DTT RDG+Q++ + +E ++I L + G+ + + F + + D + Sbjct: 42 LPDNIYITDTTFRDGQQSMP-PYTSREIVRIFDYLHELDNNSGI-IKQTEFFLYTKKDRK 99 Query: 57 SVQ-TIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + + + R + V + R ++D+ + +K ++ S HI KL+ T Sbjct: 100 AAEVCMERGYEFPEVTSWIRADKEDLKL----VKDMGIKETGMLMSCSDYHIFKKLKMTR 155 Query: 116 DEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIA-----DLARVVEAAINAGATT-INIP 169 E ++ + + + A N ED R + +++ + A I Sbjct: 156 KETMDMYLDLAREALNNGIRPRCHLEDITRADFYGFVVPFVNELMKMSKEANIPIKIRAC 215 Query: 170 DTVGYTMPFEFAGIISGL------YERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGAR 223 DT+G +P+ I + + + I H H+D V NS A GA Sbjct: 216 DTLGLGVPYNGVEIPRSVQGIIHGLRNICEVPSESIEWHGHNDFYGVVTNSSTAWLYGAS 275 Query: 224 QVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 + + GIGER GNC LE +I K + I +Q + +P Sbjct: 276 SINTSFLGIGERTGNCPLEAMIFEYAQIKGNTK---NMKLHVITELAQYFEKEIKYSVPV 332 Query: 284 NKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDE 343 VG+ +GIH DG+LK+ E Y I + I + + ++ SGRA + ++ Sbjct: 333 RTPFVGTDFNVTRAGIHADGILKDEEIYNIFDTDKILGRPVVVAVSQYSGRAGIAAWVNT 392 Query: 344 MGYKESEYNL---DNLYDAFLKLADKKGQV 370 + E + D+ D D++ + Sbjct: 393 YYRLKDEDKVNKNDSRIDQIKMWVDEQYRA 422 >UniRef50_Q1NS12 Pyruvate carboxyltransferase n=2 Tax=delta proteobacterium MLMS-1 RepID=Q1NS12_9DELT Length = 363 Score = 246 bits (629), Expect = 1e-63, Method: Composition-based stats. Identities = 95/334 (28%), Positives = 158/334 (47%), Gaps = 15/334 (4%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDF--ESVQTIARQ 64 + D+TLR+G Q + LS + ++++A L MG++ +EVG P+ D + + Q Sbjct: 4 LIDSTLREGLQTVGLDLSQERQVELAGELAAMGIEELEVG-PLRPDDDEVGQLLNRCRHQ 62 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 +R+ RC DI+ A + + I S + + KL+ V E Sbjct: 63 AGVARLAIWCRCRAADIERALAW----QPEVLALSIPISRLQMQVKLQRDEAAVKELVTA 118 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 ++R R + EDA R LA +V A GA I + DTVG P E + ++ Sbjct: 119 ALRRTRGRVGYLSLGLEDATRAEPRFLAEMVRLAKREGAHRIRLADTVGIATPAEISELV 178 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + + + I VHTH+D G+A N++AA+ AGA + + G+GERAG LEEV Sbjct: 179 RLVRD--CGGRRLAIGVHTHNDFGMAGANAIAALAAGADWADVTLLGLGERAGLARLEEV 236 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 + +R+ T + + ++ C PI + + +VGS FA +G+H + Sbjct: 237 AAYLALRRQRPYQLTG-----LPQLCARLAGFCGQPIASRQPVVGSDIFACETGLHLAAL 291 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVK 338 ++ YE P +G N+ QL +++GR A+ Sbjct: 292 QQDPATYEPFEPALVG-NRRQLLYGTKTGRQALA 324 >UniRef50_Q2LTE1 Isopropylmalate/homocitrate/citramalate synthases n=43 Tax=Bacteria RepID=Q2LTE1_SYNAS Length = 634 Score = 246 bits (628), Expect = 2e-63, Method: Composition-based stats. Identities = 89/438 (20%), Positives = 171/438 (39%), Gaps = 33/438 (7%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVD---VMEVGFPVSSPGDFESV 58 ++++ I DTT RDG+QA + + ++ + + + R+G + + F + S D E+V Sbjct: 61 AEEIFITDTTFRDGQQA-RPPYTTQQIVDLYQMMSRLGGYNGIIRQTEFFLYSNRDKEAV 119 Query: 59 QTIARQVK-NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + R +DI + E A + S HI KL T + Sbjct: 120 RMCQDLGLQYPEITGWIRAAREDIPLVKE----AGLKETGILTSVSDYHIFLKLNMTRSQ 175 Query: 118 VIERAIYMVKRARNYTDDVEFSCEDAGRTPIA-----DLARVVEAAINAGATT-INIPDT 171 +E + +VK + ED R I +++ +G I + DT Sbjct: 176 ALEEYLGIVKAILDAGIVPRCHFEDITRADIYGFCIPFAIELMKLREESGVDIKIRLCDT 235 Query: 172 VGYT-------MPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 +GY +P ++ + ++ ++ H H+D A+ N+ A G Sbjct: 236 MGYGVTYPGASLPRGVDKLVRAFIDDA-DVPGRLLEWHGHNDFHKALINATTAWLYGCSA 294 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 + G+GER GN +E +I+ ++ I+ I + IP+N Sbjct: 295 ANSTLLGLGERTGNPPIEGLIIEYI---GLMGKTNGIDTTVITDIANYFKNEIEYKIPSN 351 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEM 344 VG+ +G+H DG++K+ E Y I I I +T +SG+A + + ++ Sbjct: 352 YPFVGADFNVTRAGVHADGLIKSEEIYNIFNTTKILKRPIVPMITDKSGKAGIAYWINSH 411 Query: 345 GYKESEYNLDNLYDAFLKLAD------KKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSV 398 + +D + K+ + G+V E L + + PE F D + Sbjct: 412 FGLSGDSTVDKRHPGISKINKWIADEYELGRVTTISTEELEAKVR-KYMPELFMSDLERI 470 Query: 399 QSGSNDIATAAVKLACGE 416 + + + A A ++ + Sbjct: 471 KFKAAEAAIAVLRKIIDD 488 >UniRef50_A8MBK1 Pyruvate carboxyltransferase n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8MBK1_CALMQ Length = 419 Score = 243 bits (621), Expect = 1e-62, Method: Composition-based stats. Identities = 96/414 (23%), Positives = 174/414 (42%), Gaps = 38/414 (9%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERM-----GVDVMEVGFPVSSPGDFE 56 ++ I DTT RDG+QA + S + + L + + E F + + D Sbjct: 17 PSELYITDTTFRDGQQAF-YAYSPSDVKGLFKLLSELDNGSGRLSRSE--FFLYTERDRR 73 Query: 57 SVQTIARQV-KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 V + K +V R +D+ + ES + ++ S +HI K +T Sbjct: 74 IVNAVKGLGLKYPKVIGWGRARVEDVRLVKES----GLDEMVMLMSISDIHIKAKFNTTR 129 Query: 116 DEVIERAIYMVKRARNYTDDVEFSCEDAGRTP-IADLARVVEAAI----NAGAT-TINIP 169 V+E+ + + A + S ED R + + V + GA+ I +P Sbjct: 130 ARVVEKYLEAAEEAMRSGIALRCSLEDVTRADVLGFVVPFVNKLLRLRDKYGASLVIKLP 189 Query: 170 DTVGYTMPFEFAGI------ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGAR 223 DT G +P+ A + + + + I + H H D +AV N++AA GA Sbjct: 190 DTTGVGVPYPTASLPYSIPKLIWVMRSLLKIPSNALEFHGHGDYHMAVANAVAAWVYGAG 249 Query: 224 QVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQI--CNMPI 281 G + GIGERAGN +E +++ K + + E S++V + Sbjct: 250 INNGTLLGIGERAGNVPIEALVVWYSRLKG------SFDGMEPRVISRIVEYFKGMGYSV 303 Query: 282 PANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRM 341 P ++ IVGS A+A ++GIH D K+ E Y M P +G+ + + + +GR+ + H + Sbjct: 304 PRHQPIVGSNAYATAAGIHIDAQSKDPETYLSMDPSLVGMRET-ILIGPYTGRSGIAHVL 362 Query: 342 DEMGYK--ESEYNLDNLYDAFLKLADKK--GQVFDYDLEALAFIGKQQEEPEHF 391 +G +++ ++ +Y A ++L D+ + + + G E F Sbjct: 363 KGIGVNAGKNDETVERVYRAVVRLYDEGRLREPMSEEEFIKSMSGLINGESVKF 416 >UniRef50_Q72WS3 Homocitrate synthase n=2 Tax=Desulfovibrio vulgaris RepID=Q72WS3_DESVH Length = 384 Score = 240 bits (612), Expect = 1e-61, Method: Composition-based stats. Identities = 99/375 (26%), Positives = 160/375 (42%), Gaps = 18/375 (4%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + + V++ D+TLR+G QA ++ I + GV E G+ + D + Sbjct: 18 LRRCVMLIDSTLREGAQAYGVYFDAADRESILQGVAASGVTEAEAGW--AGQDDLAATLR 75 Query: 61 I-ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + AR + R+ RC D+D AAE A A R+H + +S H+ +L DEV+ Sbjct: 76 LGARVAPSLRLAVWCRCCTADLDKAAE----AGARRVHIGVPSSDAHMRLRLGMGRDEVL 131 Query: 120 ERAIYMVKRARNYT-DDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 +R +++ A + V EDAGR L + A GA + DTVG P Sbjct: 132 QRVTTVLEHAAHLGFLHVTLGLEDAGRAAPDLLEALARTAARTGAHRLRCSDTVGLLTPD 191 Query: 179 EFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGN 238 ++ ++VH H+DLGLA N+LAA+ AGA + ++ G+GERAG Sbjct: 192 GMVRLVLLARRA----SALPVAVHCHNDLGLATANALAALDAGADGADVSLLGLGERAGI 247 Query: 239 CSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSG 298 EE+ A+ V + + + + ++ M +P + A+ G FA SG Sbjct: 248 TRAEELAAALVVLRG-----ESYRLDMLRGVCRRLAASLEMRLPPHWAVAGENLFAVESG 302 Query: 299 IHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYD 358 +H GV ++ +E P +G + +L + + G A V G L Sbjct: 303 VHLHGVQRDPALFEPFPPALVGAER-RLGVGGKCGSAGVAAMAHSHGLTLQGDALRRHVR 361 Query: 359 AFLKLADKKGQVFDY 373 A A G+ Sbjct: 362 AVRDKACSLGRPLTD 376 >UniRef50_A0YSY8 2-isopropylmalate synthase n=1 Tax=Lyngbya sp. PCC 8106 RepID=A0YSY8_9CYAN Length = 271 Score = 240 bits (612), Expect = 1e-61, Method: Composition-based stats. Identities = 97/269 (36%), Positives = 156/269 (57%), Gaps = 5/269 (1%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 ++IFDTTLRDGE S +K+QIA LE +GVD +E+G+P D + + +++ Sbjct: 7 ILIFDTTLRDGELTPGVHFSTPDKVQIAQQLEEIGVDTIEIGYPGRYAKDIDEIIAVSQV 66 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 +K S +CALA E +I+ AA+SL+ AE I+ + + + L ++ Sbjct: 67 IKGSTLCALAGSQETEINKAAKSLEKAEKSSINIYTLVNLTSSSKTLDKN--SILSTLKK 124 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 + +A+NY + V+++ DA R I L V+ AI +GA I+IPD++G +P +F ++ Sbjct: 125 QISQAKNYCNIVQWTAFDATRGDINFLCEAVQTAIESGAKIISIPDSLGVALPEDFYNLL 184 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 LY+ +P + +SVH H+DLG AV NSL + G RQ+E A+NG+G R GN +L +V Sbjct: 185 QKLYQNIPQLQHVTVSVHCHNDLGKAVENSLVGLEVGVRQIECAVNGLGARKGNANLTKV 244 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLV 273 + I+ + +T INH I + S+L+ Sbjct: 245 VNLIQSH---HSYYTTINHNLIPKISELI 270 >UniRef50_C7YY11 Putative uncharacterized protein n=2 Tax=Nectriaceae RepID=C7YY11_NECH7 Length = 398 Score = 240 bits (612), Expect = 1e-61, Method: Composition-based stats. Identities = 78/282 (27%), Positives = 137/282 (48%), Gaps = 9/282 (3%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I DTTLR+GEQ A + K++IA AL+ GV+ +E+ P +S Q I + Sbjct: 122 IIDTTLREGEQFATAHFDTETKIKIAQALDEFGVEYLELTSPAASEQSKLDCQAICKLGL 181 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 +++ RC D +A ++ I+ I TS + LD + ++A ++ Sbjct: 182 KAKILCHIRCNMDDARIAVQT----GVDGINMCIGTSAQLMKHSHGKDLDWIAKKATEVI 237 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 + A+++ +V FS ED+ R+ +++ ++ GA + I DTVG E IS Sbjct: 238 QFAQSHGVEVRFSGEDSFRSDFSEIIKLYSLVDRLGAQRVGIADTVGGATWREVDEKIST 297 Query: 187 LYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIM 246 L + + I H H+D G AV N+ A+ AGA ++ + GIGER G SL ++ Sbjct: 298 LRQVI----SCDIETHFHNDTGCAVSNAFTALEAGATHIDTTVLGIGERNGITSLGGLMA 353 Query: 247 AIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIV 288 ++ + +V +++ +LV++ ++ IP N +V Sbjct: 354 SLMYSEH-KSVLNKYKLEKLAALEELVAKAVDVEIPWNNFVV 394 >UniRef50_D0LGL9 2-isopropylmalate synthase n=3 Tax=Nannocystineae RepID=D0LGL9_HALO1 Length = 424 Score = 238 bits (607), Expect = 5e-61, Method: Composition-based stats. Identities = 83/376 (22%), Positives = 164/376 (43%), Gaps = 21/376 (5%) Query: 3 QQVIIFDTTLRDGEQALQA-SLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 +QV TLRDG Q+ + +KL++ + +G+ +++G P + E TI Sbjct: 29 RQVSFLCETLRDGIQSPSVVDPDIGDKLRLVELADSLGIHHIDIGLPGAGNRAVEDCTTI 88 Query: 62 ARQVKNSRVC----ALARCVEKDIDVAAE-SLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 A ++++++ AR + D+ + S V + TFI +SP+ L+ Sbjct: 89 ATFIRDNKLRIRPACAARTHKNDVGAIVDISQAVGIEIEVLTFIGSSPI-RQYAESWDLE 147 Query: 117 EVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTM 176 ++ + + A + V F ED R+ L ++ AI GA + + DTVG++ Sbjct: 148 RMLNFSSEAIDLAARHNLPVTFVTEDTTRSRPEVLDQMFRNAIEHGANRLCLCDTVGHST 207 Query: 177 PFEFAGIISGLYERVP--NIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 P +I + I H H+D GL V N++ A+ GA +V G G+GE Sbjct: 208 PDGIHNLIRFTRNLLEAMGRPDVGIDWHGHNDRGLGVVNTIFAIEYGASRVHGTAMGLGE 267 Query: 235 RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFA 294 R GN +L++V + +L + ++ ++ ++ C++ IP + GS AF Sbjct: 268 RVGNAALDQV----LLNLKLLGELPEQDLSKLLLWCKVAAKACHVAIPPQYPLAGSDAFR 323 Query: 295 HSSGIHQDGVLKNRENYEIM--------TPESIGLNQIQLNLTSRSGRAAVKHRMDEMGY 346 ++G+H ++K + P + + ++ + SG + V + + + G+ Sbjct: 324 TATGVHAAAIIKAEKKGHEWLADRIYSGVPAGMFGREQEIEIGHYSGESNVIYWLRKRGF 383 Query: 347 KESEYNLDNLYDAFLK 362 + + + A + Sbjct: 384 DPTPELVRTVLSAAKR 399 >UniRef50_B1QUV5 Homocitrate synthase 1 n=2 Tax=Clostridium butyricum RepID=B1QUV5_CLOBU Length = 265 Score = 237 bits (605), Expect = 9e-61, Method: Composition-based stats. Identities = 76/273 (27%), Positives = 123/273 (45%), Gaps = 13/273 (4%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M + V I DTTLRDGEQ+ + ++++KL+IA L+ G+ +E G P + E ++ Sbjct: 1 MKRNVNIVDTTLRDGEQSAGKAFTMEQKLKIAKYLDNNGIYQIECGIPAMGCMEQEIIKA 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I KN+ + R DI + + IH + S + I L + E Sbjct: 61 IKANTKNALISTWNRLNIDDIKAS----MNCKPHIIHISVPVSDLQIYENLNKDKKWIEE 116 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 I + + DV EDA R I + + G I DTVG + Sbjct: 117 NLIKCIYYTKEQGYDVTVGLEDASRADIKYIIELSSLIEKLGVNRIRYSDTVGILSLLKT 176 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 +++ + + +H H+D G+A+G S+ AV GA V+ ++GIGER GNCS Sbjct: 177 KNVVNEIRRN----SNLKVEIHAHNDFGMALGISVEAVKNGAEFVDCTLDGIGERTGNCS 232 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLV 273 L+E +K+ ++ + N I + +LV Sbjct: 233 LQEF---LKISRNFECDYEMNNDNVIKK--RLV 260 >UniRef50_UPI0001B425AC 2-isopropylmalate synthase n=1 Tax=Listeria monocytogenes FSL J1-208 RepID=UPI0001B425AC Length = 258 Score = 235 bits (601), Expect = 2e-60, Method: Composition-based stats. Identities = 92/242 (38%), Positives = 143/242 (59%), Gaps = 3/242 (1%) Query: 256 NVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMT 315 T I + +S L+S++ MP+P NKA++G A+AH SGIHQDGVLKN + YEI+T Sbjct: 1 QAETNIVLNQFKNSSDLISRLSGMPVPRNKAVIGGNAYAHESGIHQDGVLKNPDTYEIIT 60 Query: 316 PESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDL 375 P +G+++ L L SG+ A RM+E+GY SE L + + F +LAD K +V + DL Sbjct: 61 PALVGVDKNSLPLGKLSGKHAFLTRMEEIGYTLSEKELKDAFKRFKQLADAKKEVTEDDL 120 Query: 376 EALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKL-ACGEEVKAEAANGNGPVDAVYQ 434 AL +G+ E + F L + VQ + + A V++ + +AA G+G ++A+Y Sbjct: 121 HALI-LGQSSESADDFELKHLQVQYVTGGVQGAIVRIEERNGALIEDAATGSGSIEAIYN 179 Query: 435 AINRITEYNVELVKYSLTAKGHGKDALGQVDIVANY-NGRRFHGVGLATDIVESSAKAMV 493 INR+ + ++EL Y + A G+DA +V +V NG FHG+G+ D++ +SAKA + Sbjct: 180 TINRLMKQDIELTDYRIQAITAGQDAQAEVHVVIKDNNGTEFHGIGIDFDVLTASAKAYL 239 Query: 494 HV 495 Sbjct: 240 QA 241 >UniRef50_C1MYB9 2-isopropylmalate synthase n=1 Tax=Micromonas pusilla CCMP1545 RepID=C1MYB9_9CHLO Length = 757 Score = 230 bits (588), Expect = 8e-59, Method: Composition-based stats. Identities = 97/403 (24%), Positives = 166/403 (41%), Gaps = 21/403 (5%) Query: 19 LQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI-------ARQVKNSRVC 71 + SL+ +KL++A L +GV +E G+P S+P D E A + + +++C Sbjct: 149 VGISLTCDDKLEVASHLVSLGVSHIEGGYPGSNPKDVEFFNRWDSSGLAKAAEARGTKLC 208 Query: 72 ALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVK 127 A K + D +L A L + +E + V Sbjct: 209 AFGMTRRKGVEAKDDEGLNALVRCVAPCACIVAKAWDEQCERVLGVSGEENLAMITDSVS 268 Query: 128 RARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 +V CE D R AA AGAT + + DT G T+P+ Sbjct: 269 YLVERGKEVLVDCEHFYDGHAANGEFAMRCAVAAAEAGATHVVLCDTNGGTLPWVVEEKT 328 Query: 185 SGLYERVPNI--DKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + + + + VHTH+D LAV NSLA V GA V+G +NG GER GN + Sbjct: 329 RAVVDALKKSSNPSCRVGVHTHNDTALAVANSLAGVRGGASMVQGCVNGYGERTGNADVL 388 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 V ++++ + + + + + ++ C P+ A + VGS AFAH G+H Sbjct: 389 VVAANLELKMGVTALPPGGVAKLTATAAAV-AKACKQPLEARQPYVGSSAFAHKGGLHVA 447 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 + K +Y + P ++G N + ++ SGR V G + S+ + + Sbjct: 448 ALAKMPSSYNHVVPGTVG-NAARSVVSELSGRGNVLSAAVAAGREVSKDTAGIVLAQIKE 506 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEH--FRLDYFSVQSGSN 403 L + KG V + ++ + ++ F + F+V + +N Sbjct: 507 L-ESKGFVLEDAGASVDILFQRAAAGYRAPFNVLEFNVSASNN 548 Score = 50.7 bits (120), Expect = 1e-04, Method: Composition-based stats. Identities = 22/85 (25%), Positives = 36/85 (42%), Gaps = 10/85 (11%) Query: 422 AANGNGPVDAVYQAINRITEYN------VELVKYSLTAKG--HGKDALGQVDI--VANYN 471 A GNGPV+A+ A+ + LV Y + A+ +V + V Sbjct: 642 VAEGNGPVNALANALQLALNERFPQLKRIHLVDYQVDLLSSEGTSAAVTRVTMDFVDRGG 701 Query: 472 GRRFHGVGLATDIVESSAKAMVHVL 496 G + VG I+E+S +A+V + Sbjct: 702 GGTWRTVGAHASIIEASFRALVDGM 726 >UniRef50_A8MB07 2-isopropylmalate synthase n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8MB07_CALMQ Length = 355 Score = 228 bits (582), Expect = 3e-58, Method: Composition-based stats. Identities = 87/376 (23%), Positives = 162/376 (43%), Gaps = 44/376 (11%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 +I D TLR+G QA S +V+EK+++A + GVD V P + + E + I + Sbjct: 1 MIIDDTLREGLQAPGISFTVEEKIELAKLISNAGVDEAIVSHPSAHESEVEVTRIIVERN 60 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 V L R +++DID L + I T+I P + L +VI+ A+ Sbjct: 61 YFKYVFGLGRALKEDID-----LIASTGANISTYIPFEPQLVNKSL-----DVIKYAVNT 110 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 + + +E + ++++ ++ + G I + D++G P I++ Sbjct: 111 YGKGK---LIIEVGITNITAYELSNIVKLAKTLEELGVDRIQLADSLGKATPKLMYNIVN 167 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245 + V K +SVH H+D+G AV NS+++V+AGA V+ + GIGER G L + Sbjct: 168 NVKHTV----KIPVSVHCHNDMGAAVANSISSVYAGADYVDATIYGIGERNGIADLATIA 223 Query: 246 MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIP-----ANKAIVGSGAFAHSSGIH 300 M ++ + I+ +++ ++++ I N + G+ ++G H Sbjct: 224 MILRN----DSYRINIDFEKLRDAYNYLAKLIIDKIDIEFFRNNFPVFGNNISIQTAGTH 279 Query: 301 QD--GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYD 358 GV K ++ +L GR+ ++ + E+G ++ L L Sbjct: 280 AAYPGVFK----------------EVGYSLNVYVGRSTLRKVLSELGISLNDQELLMLMR 323 Query: 359 AFLKLADKKGQVFDYD 374 A + G+ YD Sbjct: 324 KIKDTAVRTGRAVTYD 339 >UniRef50_Q6T1C1 2-isopropylmalate synthase (Fragment) n=1 Tax=Xenorhabdus nematophila RepID=Q6T1C1_XENNE Length = 210 Score = 228 bits (582), Expect = 4e-58, Method: Composition-based stats. Identities = 132/187 (70%), Positives = 159/187 (85%) Query: 330 SRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPE 389 SRSGRAAVKHRM EMGY+E++Y+LD LY AFLKLADKKGQVFDYDLEAL FI +QQ+E E Sbjct: 1 SRSGRAAVKHRMTEMGYQENDYDLDILYQAFLKLADKKGQVFDYDLEALVFINQQQQEYE 60 Query: 390 HFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKY 449 H+RLDYFS+QSG+N + TA V+LACG+E+ +EAA GNG VDA+YQAI RIT Y ++L+ Y Sbjct: 61 HYRLDYFSIQSGTNVVPTATVRLACGDEITSEAATGNGTVDAIYQAIGRITGYPLKLISY 120 Query: 450 SLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKEL 509 L+ KGHGKDALGQVDI+ GRRFHG+GL TDI+ESSA+AM+HVLNNIW+A +VEKE Sbjct: 121 QLSGKGHGKDALGQVDIIVECFGRRFHGMGLETDIIESSARAMIHVLNNIWQAEQVEKEK 180 Query: 510 QRKAQHN 516 QR + N Sbjct: 181 QRISHCN 187 >UniRef50_Q00853 Homocitrate synthase subunit alpha n=8 Tax=Clostridium RepID=NIFVA_CLOPA Length = 269 Score = 227 bits (579), Expect = 9e-58, Method: Composition-based stats. Identities = 82/249 (32%), Positives = 116/249 (46%), Gaps = 8/249 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + I DTTLRDGEQ +LSV++K++IA + MGV +E G P + SV IA Sbjct: 3 INIVDTTLRDGEQKAGIALSVQDKVEIAKIISEMGVHQIEAGIPAMGGDEKISVSKIAAL 62 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 S++ A R KDID + E +H S + I TKL V E Sbjct: 63 GLPSKIAAWNRMSTKDIDTSIE----CGVDIVHISSPVSDLQIKTKLEKDRKWVAENLKR 118 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 V A +V ED+ R + L ++ E G + DTVG P E I Sbjct: 119 TVIYALEKDCEVTVGLEDSSRADLNFLIQLCEMIFALGVKRVRYADTVGIMEPKELYSQI 178 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + ++VP I +H H+D G+A+ NS AA AGA+ + + G+GERAGNC + Sbjct: 179 KKIRDKVP----IDIEIHVHNDFGMAISNSFAAFKAGAKFADCTITGMGERAGNCDFLKF 234 Query: 245 IMAIKVRKD 253 + I+ Sbjct: 235 VKVIQELTG 243 >UniRef50_B4WHZ2 HMGL-like domain protein n=1 Tax=Synechococcus sp. PCC 7335 RepID=B4WHZ2_9SYNE Length = 411 Score = 226 bits (576), Expect = 2e-57, Method: Composition-based stats. Identities = 86/394 (21%), Positives = 156/394 (39%), Gaps = 46/394 (11%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 ++I D TLRDGEQ + ++K +A + + GV + P + + V ++ Sbjct: 6 LLISDETLRDGEQQVGLFF--EDKTTLANLIAQTGVQQI-ALMPAIHTSEAKLVSSLVDS 62 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSP-------MHIAT-------- 109 ++ A A E K ++ F A S + IA Sbjct: 63 GLKRQIVASTMMRR----AAIEHAKTCGVRQVILFHAVSDRLLFLRDLEIAKDPRFKGKT 118 Query: 110 --------KLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINA 161 ++ + ++ A+ V+ A + F+ EDA R L + Sbjct: 119 IDDDIDLPVIQRSRQRMLIHALEHVRYAAEQGLRICFAAEDASRADNDFLVECINTLSPY 178 Query: 162 GATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAG 221 + DTVG P A I L + + +SVH H+D+GLA+ N++ AV AG Sbjct: 179 -IDEFLLCDTVGSLTPKRTALWIQNLLQHTRAVP---LSVHFHNDMGLALENTIQAVCAG 234 Query: 222 ARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPI 281 AR + G GIGERAGN +E+V+ ++ R I++ + + + + P Sbjct: 235 ARGISGTFGGIGERAGNAPIEQVLKGLRSRFGWE--VAGIDYDALDQVVDYLHAQGHRP- 291 Query: 282 PANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRM 341 + A H SGIH +L++R +Y I Q ++ SG + ++ Sbjct: 292 --HAPY-SRQAQRHESGIHVSALLRDRRSYSIFPH-----QQPEIWFGKGSGSSNFQYLF 343 Query: 342 DE-MGYKESEYNLDNLYDAFLKLADKKGQVFDYD 374 ++ + + + + L +A ++ + F + Sbjct: 344 EQYLNWPLPQCEYERLRAIVKAIAIREKRSFSVE 377 >UniRef50_Q97A78 2-isopropylmalate/homocitrate synthetase n=1 Tax=Thermoplasma volcanium RepID=Q97A78_THEVO Length = 344 Score = 225 bits (575), Expect = 2e-57, Method: Composition-based stats. Identities = 78/382 (20%), Positives = 154/382 (40%), Gaps = 45/382 (11%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 ++ D TLR+G QA + ++ EK++IA ++ + G+ V +P + + E+ + I Sbjct: 1 MLTDDTLREGMQAPGIAFTLDEKIRIAQSISKSGIKRALVSYPSAHESEVEAARKITDLH 60 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 +L R +++D+D + ++ + I + + Sbjct: 61 LFDDTYSLGRSIKEDVDSIIST-----GSKVTLHLPFGDY------------DINKICDV 103 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 VK A +++D VE + D + + + + GA+ + IPDT G P ++S Sbjct: 104 VKYASDHSDSVEIAIVDMVKYEKEKIFDLAKKLWECGASIVQIPDTTGRATPKRVHDVVS 163 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245 + + + K + VH H+D GLA+ NS+A + AG V+ + GIGER G + Sbjct: 164 YIKQNL----KVKVEVHCHNDHGLAIANSIAGIEAGCDYVDTTIFGIGERNGIADTASIA 219 Query: 246 MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMP-----IPANKAIVGSGAFAHSSGIH 300 ++ IN + + +T L+S++ N I G + ++G H Sbjct: 220 SYLE----KAGYEDKINFEMLRKTYDLMSELILRKAGYRFFADNMPIFGRNVLSITAGTH 275 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 ++ +++L +G V + + G + E + L Sbjct: 276 --------STSKVFP-------NSRVSLNVYAGSRLVASILRKNGIEPDERKVKLLVSKI 320 Query: 361 LKLADKKGQVFDYDLEALAFIG 382 L+ +G+V D + G Sbjct: 321 KDLSSNEGRVVGEDEVLKIYGG 342 >UniRef50_C8QZK2 2-isopropylmalate synthase n=1 Tax=Desulfurivibrio alkaliphilus AHT2 RepID=C8QZK2_9DELT Length = 399 Score = 219 bits (558), Expect = 2e-55, Method: Composition-based stats. Identities = 90/349 (25%), Positives = 161/349 (46%), Gaps = 25/349 (7%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPV------SSPGDFES- 57 V + D+TLR+G Q + LS+ ++ +A +G++ +EVG PV PGD+ + Sbjct: 2 VGLIDSTLREGLQGVGVELSLDRQVAVAAGSVALGLEELEVG-PVGLAAATMEPGDYLAR 60 Query: 58 -VQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 + + + R+ RC+ DI+ + + I S + +KL T Sbjct: 61 LIPRLRHEAGVRRLALWCRCLPDDIERSL----ALNPDVLALSIPASHRQMTSKLGKTAA 116 Query: 117 EVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTM 176 EV A ++ AR + ED R + ++ A++ G + + DTVG + Sbjct: 117 EVRTLAAAALELARGRVPYLALGLEDVTRAEPNFVRQMAVLAVDHGVDRLRLADTVGISA 176 Query: 177 PFEFAGIISGLYERVPNI------DKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMN 230 P E A ++ + E + ++ I VHTH+D GLA N++AA+ AGA + ++ Sbjct: 177 PDEIADLVGRVREYLREAGGDGRGNQVAIGVHTHNDFGLAGANAIAALAAGADWADVSLL 236 Query: 231 GIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGS 290 G+GERAG LEEV + +R+ + + +Q ++ C IP+ + +VG Sbjct: 237 GLGERAGLARLEEVATYLALRRG-----HHYRLERLPELAQQLAGFCGREIPSWRPVVGR 291 Query: 291 GAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKH 339 F+ +G+H + + +YE PE +G + L ++G A+ Sbjct: 292 DVFSCETGLHLAAIQLDPASYEPFAPELVGQRRT-LLYGVKAGHRAIAR 339 >UniRef50_B2J8P8 Pyruvate carboxyltransferase n=2 Tax=Nostocaceae RepID=B2J8P8_NOSP7 Length = 392 Score = 215 bits (549), Expect = 3e-54, Method: Composition-based stats. Identities = 93/400 (23%), Positives = 160/400 (40%), Gaps = 46/400 (11%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 +II D TLRDGEQ S K ++A + + GVD + + P + E V+++ + Sbjct: 6 IIISDETLRDGEQQAGIFFSYPTKQKLAHLIAQTGVDRLSM-MPRVHEQEEELVKSLVSE 64 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHI----------------- 107 +S + A ++ ID A K+ RI F S + Sbjct: 65 GLDSLIAAATMTGKQYIDQA----KMYGVKRIILFYGLSDRLLFLRDPQIRLLNEFKGKT 120 Query: 108 ------ATKLRSTLDEVIERAIYMVKRARNY-TDDVEFSCEDAGRTPIADLARVVEAAIN 160 + I+ + + A V+F+ EDA R L + + + Sbjct: 121 IDDDIPKKVIERIRQNAIDLIVENLHYATTVAGLTVDFAAEDASRADFDFLVQCIRSFSP 180 Query: 161 AGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHA 220 + DTVG P + I+ L +R VH H+D+GLA+ N+L +V A Sbjct: 181 Y-LDHFMLCDTVGVLTPEKSYIWINDLLQRTTG---VAFGVHYHNDMGLALENTLQSVIA 236 Query: 221 GARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMP 280 GA V G GIGERAGN ++E+V+ ++VR I IN+ I + + Q+ P Sbjct: 237 GATLVSGTFCGIGERAGNVAIEQVLNGLRVRFGIE--VKGINYDAIAAVTDYIEQLGIRP 294 Query: 281 IPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHR 340 P A H SGIH + + + ++Y + +I ++ SG + ++ Sbjct: 295 APP----YSQTAQRHESGIHVNSLFSDPQSYAALPYNTI-----EVLFGKWSGISNFQYL 345 Query: 341 MDEMGYKESEYNLDNLYDAFLK--LADKKGQVFDYDLEAL 378 ++ N + +K +++ ++ L Sbjct: 346 FEKQLQNPQPRNQYEKMRSVIKSLAVEQERYFTAKEVLEL 385 >UniRef50_Q1IW44 HMGL-like domain protein n=4 Tax=Bacteria RepID=Q1IW44_DEIGD Length = 436 Score = 207 bits (526), Expect = 1e-51, Method: Composition-based stats. Identities = 86/393 (21%), Positives = 139/393 (35%), Gaps = 35/393 (8%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVD---VMEVGFPVSSPGDF-- 55 + + +TT RDG+Q L+ + L I + + D + + F V P D Sbjct: 39 LPRVAWTTETTHRDGQQG-GLPLTTADGLAIYDLMGKFTGDSGAIRQAEFFVYRPADRAM 97 Query: 56 -ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLR-S 113 E R R +D ++ AE + S H K Sbjct: 98 LEGALERWRGGHPVEPTTWIRATRRDAELVAE----LGVRETGMLASASDYHTFYKFTPG 153 Query: 114 TLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAIN-------AGATTI 166 + + V+ + EDA R P + V A A A Sbjct: 154 GRAQAARTYLDAVRAVLDAGLRPRLHLEDATRAPREFILPFVAAVQEVSAPYGEAQAPKF 213 Query: 167 NIPDTVGYTMPFE-------FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVH 219 + DT+G +P E G+I L + + H H+D L V N LAAV Sbjct: 214 RVCDTMGVGLPLEGVAWPRSVPGMIRELVAA--GVPGEQLEFHPHNDTHLVVANCLAAVI 271 Query: 220 AGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNM 279 AG + G + G GER GN LE V++ + + +++ + + L ++ Sbjct: 272 AGCAAINGTLLGKGERTGNAPLEGVLL---HLIGLNLLLGQPDYRALNELADLYERL-GQ 327 Query: 280 PIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKH 339 +PA + G A +GIH DG+ K Y + ++L+LT SG A + Sbjct: 328 GVPAKYPLYGRDAHRTRAGIHADGLNKFWPMYAPFDVPQLLGRPLELSLTKDSGLAGLIF 387 Query: 340 RMDEM-GYKESEYN--LDNLYDAFLKLADKKGQ 369 + + G + + + L L D Q Sbjct: 388 LIKQHAGVELDKAHPGLRALQAELTAEFDAGRQ 420 >UniRef50_P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial n=241 Tax=cellular organisms RepID=HMGCL_HUMAN Length = 325 Score = 203 bits (516), Expect = 2e-50, Method: Composition-based stats. Identities = 67/296 (22%), Positives = 126/296 (42%), Gaps = 29/296 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP-----GDF 55 + ++V I + RDG Q + +S K+++ L G+ V+E VS GD Sbjct: 29 LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDH 88 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 V ++ L ++ E+ A A + F A S + + ++ Sbjct: 89 TEVLKGIQKFPGINYPVLTPNLK-----GFEAAVAAGAKEVVIFGAASELFTKKNINCSI 143 Query: 116 DEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIP 169 +E +R ++K A++ V C G+ A +A V + + G I++ Sbjct: 144 EESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLG 203 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G P ++S + + VP A ++VH HD G A+ N+L A+ G V+ ++ Sbjct: 204 DTIGVGTPGIMKDMLSAVMQEVP---LAALAVHCHDTYGQALANTLMALQMGVSVVDSSV 260 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNM 279 G+G +GN + E+++ ++ L +HT +N Q++ + Q N Sbjct: 261 AGLGGCPYAQGASGNLATEDLVYMLE----GLGIHTGVNLQKLLEAGNFICQALNR 312 >UniRef50_D1PZE3 2-isopropylmalate synthase (Fragment) n=1 Tax=Prevotella bergensis DSM 17361 RepID=D1PZE3_9BACT Length = 264 Score = 202 bits (514), Expect = 2e-50, Method: Composition-based stats. Identities = 62/250 (24%), Positives = 110/250 (44%), Gaps = 9/250 (3%) Query: 256 NVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMT 315 +V T IN ++ S++V + + N+ IVG F +G+H DG K+ + Sbjct: 3 HVRTNINESQLNMISRVVEDHSGIAVAPNQPIVGENVFTQVAGVHADGDNKDNLYCNELK 62 Query: 316 PESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDL 375 PE G + L SG+A ++ ++E+G + + + +L D+K V DL Sbjct: 63 PERFGRKRA-YALGKNSGKANIEKNLEELGMELTPEQTRMVTQRITELGDRKEFVTQADL 121 Query: 376 EALA-FIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQ 434 + + K + + +L + V + A++K+ + + G+G DA + Sbjct: 122 PFIVSDVLKHNTQEDCVKLLSYMVSTSYGLKPIASIKVEINGKDYMGESTGDGQYDAFVK 181 Query: 435 AINRITEYNV-----ELVKYSLTAKGHG-KDALGQVDIVA-NYNGRRFHGVGLATDIVES 487 A+ +I + N+ L Y+++ G DAL Q I +GR GL D ES Sbjct: 182 ALRKIYKENLNRTFPRLANYTVSIPPGGHTDALVQTVITWHEESGRMIRTQGLDVDQTES 241 Query: 488 SAKAMVHVLN 497 + KA +LN Sbjct: 242 AIKATFKMLN 251 >UniRef50_B4VB43 2-isopropylmalate synthase n=1 Tax=Streptomyces sp. Mg1 RepID=B4VB43_9ACTO Length = 474 Score = 202 bits (513), Expect = 4e-50, Method: Composition-based stats. Identities = 83/398 (20%), Positives = 169/398 (42%), Gaps = 22/398 (5%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERM-GVD-----VMEVGFPVSSPGDFES 57 +V++++ + RDG QA + ++ ++++A R+ G D V+ GFP +FE+ Sbjct: 53 RVVLWEESARDGAQA-KTLMTAGFRVRLARETGRIFGSDGPRHVVIAAGFPAVCGEEFEA 111 Query: 58 VQTIARQVKNSR-VCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 V+ +A + + + V A+ R +D++ A S++ + R+ + S + Sbjct: 112 VRRVAGEAEGAVSVAAVCRGARRDLEQAVASVRGSRQARVMVVVPASEAMARVMVHRAAR 171 Query: 117 EVIERAIYMVKRARNY--TDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGY 174 E ++ + +VKRAR+ V+ DA R A +A A AGA + + DTVG Sbjct: 172 EALQAGVDLVKRARDLDEGVAVDVCLADASRADHALMAHYARAMTGAGAGLVVLADTVGA 231 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 +P A + + + +++ H H+DLGL + N+L A+ AG R + GI E Sbjct: 232 QLPSGCAEMFRRVRAEAG--SEVVLASHLHNDLGLGLANTLEALAAGVRVASSSWLGIAE 289 Query: 235 RAGNCSLEEVIMAIK------VRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIV 288 RAG + E+++ + + + + + +++V+ +P+ IV Sbjct: 290 RAGMVATEQLLFLLARHARELLGAGAAPWWSPPDLTRLPVIAEMVAGETGVPLGVTTPIV 349 Query: 289 GSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE 348 G+G + S+G + ++ P+ + ++ LT + V +G+ Sbjct: 350 GTGVGSLSTGT----PFVHPRLFQPYDPQELLGITPRVVLTHLASARVVAAVATRLGHTL 405 Query: 349 SEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQE 386 A + G+ D ++ + Sbjct: 406 DGERTRTAMAWVKGRAYRTGRAVVEDDAFADYLDGLTQ 443 >UniRef50_A6CMV0 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillus RepID=A6CMV0_9BACI Length = 311 Score = 201 bits (511), Expect = 6e-50, Method: Composition-based stats. Identities = 59/296 (19%), Positives = 121/296 (40%), Gaps = 27/296 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVG---FPVSSPGDFES 57 + ++V + + RDG Q + + K+Q AL+ G+ ME+ P P ++ Sbjct: 16 LPKKVTMIEVGPRDGLQNEKNFVPTDIKIQFIRALKEAGLKEMELTSFVSPKWVPQMKDA 75 Query: 58 VQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + + + R LA K +D E+ + + F+ S + T E Sbjct: 76 SEIVESCLNSERDIVLAP-NRKGVDRVLET----KGKAVAVFVGVSNSFNKKNINKTTAE 130 Query: 118 VIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIPDT 171 +E +V + V F C G+ P + ++ ++ G +++ DT Sbjct: 131 SLEELKPIVGELKEKGYFVRACISTSFYCPYEGKIPPQETLQLCREFVDMGVDELSVADT 190 Query: 172 VGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNG 231 +G P E + S L + +P +++ H HD +A+ N LA++ AG + + + G Sbjct: 191 IGMANPKESFELFSLLKKTLPE---VLMTAHFHDTRKMALANILASLQAGVDRFDTSAGG 247 Query: 232 IG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPI 281 +G +GN + E+V+ + + + T ++ + LV+ + I Sbjct: 248 LGGCPFAPGASGNAATEDVVFMLHQ----MGIETGVDLDSLTAAVNLVAPHLSRTI 299 >UniRef50_B9K380 Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Agrobacterium vitis S4 RepID=B9K380_AGRVS Length = 420 Score = 200 bits (509), Expect = 1e-49, Method: Composition-based stats. Identities = 83/381 (21%), Positives = 157/381 (41%), Gaps = 24/381 (6%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVD------VMEVGFPVSSPGD 54 +S +VI + RDG Q + L+ +++QIA + + V GFP + + Sbjct: 10 LSNRVIFHEEVARDGAQG-KTLLNGHQRVQIAKRHSSIFGEFAPYHLVFNAGFPSAGKDE 68 Query: 55 FESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRST 114 E+ + + V V A R +D+D+ +++ A RI + S + + T Sbjct: 69 LEATRQVVDCVDECYVGAAGRATRQDVDLLLQAVHGARHGRIFIAVPASNPMAYSMMHCT 128 Query: 115 LDEVIERAIYMVKRARNY--TDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTV 172 ++ + A+ MV+ AR+ V+ + DA R+ + LA AGA+ + + DTV Sbjct: 129 AEKAKQAALDMVRYARDKNPALMVDVALADASRSDVGFLAASAAEYAAAGASMVIVCDTV 188 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G P E L R + H H+DLG + N+L A+ A + + + Sbjct: 189 GQFFPSESRWFFDELARR--SDPDLRYVAHMHNDLGFGLVNTLEALSAKIYGLTSSWLSL 246 Query: 233 GERAGNCSLEEVIMAIKVRKDILNVHTAI---------NHQEIWRTSQLVSQICNMPIPA 283 GERAG + E+++ A+ + +L + + +++ ++ VSQ P+ Sbjct: 247 GERAGMPATEQLLFALGYQSSLLPKKLGVVDEIWRSPPDLRQLSPIARYVSQSTRRPLMT 306 Query: 284 NKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDE 343 IVG+G S+G N ++ P I + ++ L+S + + Sbjct: 307 TDPIVGTGVNTISTGT----PFTNPALFQPFDPLEILGVEPKVLLSSLASHRIIHAVAAR 362 Query: 344 MGYKESEYNLDNLYDAFLKLA 364 +G+ + + A Sbjct: 363 LGWALDQSQASAALEWVKAEA 383 >UniRef50_C0GGI7 Pyruvate carboxyltransferase n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GGI7_9FIRM Length = 307 Score = 198 bits (505), Expect = 3e-49, Method: Composition-based stats. Identities = 65/302 (21%), Positives = 130/302 (43%), Gaps = 29/302 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPG-----DF 55 +S V+I + LRDG Q + ++ ++K+++A AL G+ +E+ VS D Sbjct: 7 LSGDVLIREVGLRDGLQNEKQFVATEDKIRLARALTAAGLREIEITSFVSPKAVPQMRDA 66 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + + Q + AL AE + + ++ S H +R ++ Sbjct: 67 KEIVAALGQPEGVTYSALVVNRR-----GAEDAIASGVKELQYVVSCSETHSQKNVRMSV 121 Query: 116 DEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIP 169 DE +++A + A+ + F C G+T + ++E + G +++ Sbjct: 122 DEALQQAAIISDLAKENGLTIRTALSATFGCPFEGKTSYDRVYDLLEKLFSLGVERVSLS 181 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT G P + A + G+ R P S+H HD GL + +LA V AG R +E ++ Sbjct: 182 DTAGLGNPRQVAQLCQGIVARFPE---DRFSLHLHDTRGLGLACTLAGVWAGIRVIESSI 238 Query: 230 NGIGE------RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 G+G GN + E+V+ ++ + + T ++ Q++ + + +I + + Sbjct: 239 GGLGGCPFVPNATGNIATEDVVYMMEE----MGISTGLDWQQLMNAAMMAEKILGRDLNS 294 Query: 284 NK 285 + Sbjct: 295 KQ 296 >UniRef50_UPI000038E183 2-isopropylmalate synthase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E183 Length = 345 Score = 196 bits (499), Expect = 2e-48, Method: Composition-based stats. Identities = 66/368 (17%), Positives = 130/368 (35%), Gaps = 36/368 (9%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 ++ D TLR+G Q ++S EK+++A + G+ V +P + +FE I Sbjct: 1 MLTDDTLREGMQTPGFAMSYDEKIELAKLISSAGIKRALVAYPPAHKSEFEVTAAIVDGK 60 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 +V L R V++DID+ E+ A +H+ KL + + + Sbjct: 61 YFQQVFGLGRTVKEDIDMINET------------GANISLHLPFKL-----DNMGQVYEN 103 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 +K A VE D + + + + +PDT G P I Sbjct: 104 IKYACTLGKIVEIGFVDIDMFSVEQITKFCHKMEELNVDVVQLPDTRGKMNP----AAIK 159 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245 ++E I H H+D G+AV N+++A+ AG ++ + G GER G + Sbjct: 160 NVFEAAKKATNIKIEAHCHNDYGMAVANTISAISAGVDYIDTTIFGTGERNGIADSITLA 219 Query: 246 MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMP-IPANKAIVGSGAFAHSSGIHQDGV 304 + ++ + L+ + M N + G+ + ++G H Sbjct: 220 DYLMKNNLEKSLDIKGIIKAYNYVYGLILKKIGMNFFTDNLPVYGNNSGIQTAGTHV--- 276 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 T + ++ +G+ + +D + + + Sbjct: 277 ----AYGNAFT-------EKNYSVNVYTGKKMIMEILDNNNVTYDREKIGKIVSMIKDES 325 Query: 365 DKKGQVFD 372 +G+ Sbjct: 326 AIRGEALP 333 >UniRef50_Q2RAU5 Hydroxymethylglutaryl-CoA lyase, mitochondrial, putative, expressed n=8 Tax=cellular organisms RepID=Q2RAU5_ORYSJ Length = 387 Score = 194 bits (493), Expect = 7e-48, Method: Composition-based stats. Identities = 61/297 (20%), Positives = 118/297 (39%), Gaps = 29/297 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP-----GDF 55 + + V I + RDG Q ++++ K+++ L G+ V+E VS D Sbjct: 89 LPRFVKIVEVGPRDGLQNEKSTVPASVKIELIHKLVASGLSVVEATSFVSPKWVPQLADA 148 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + V R V + R L + E+ A A + F + S + L T+ Sbjct: 149 KDVLQGIRHVPDVRFPVLTPNLR-----GFEAALAAGAKEVAVFASASESFSKSNLNCTI 203 Query: 116 DEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIP 169 E + R +V A+ + + C G + +A V + + G + I++ Sbjct: 204 KESLVRYRDVVTSAKKHGMRIRGYVSCVVGCPVEGTIHPSKVAYVAKELYDMGCSEISLG 263 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G P ++ + VP ++VH HD G A+ N L ++ G V+ ++ Sbjct: 264 DTIGVGTPGSILAMLEAVMSFVP---VDKLAVHFHDTYGQALANILVSLQLGINIVDSSV 320 Query: 230 NGIGE------RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMP 280 +G+G GN + E+V+ + L + T ++ ++ +S+ Sbjct: 321 SGLGGCPYAKGATGNVATEDVVYMLH----GLGIETNVDLNKLMDAGDYISKHLGRQ 373 >UniRef50_C0WB33 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria RepID=C0WB33_9FIRM Length = 315 Score = 193 bits (490), Expect = 2e-47, Method: Composition-based stats. Identities = 66/297 (22%), Positives = 122/297 (41%), Gaps = 29/297 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVG---FPVSSPGDF-- 55 + +++ I + LRDG Q + + +EKL++ + + G V+EVG P + P Sbjct: 2 LPKKIRICEVGLRDGLQNEKRMFTTEEKLELLDGMGKAGFSVIEVGSFMSPKAVPQMANT 61 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + V +V AL + ++ A ++ ++ S H L T Sbjct: 62 DEVYEKLEKVPGVEYRALI-ANLRGVERAI----ACGCKKVKLNVSASRAHNLANLNRTP 116 Query: 116 DEVIERAIYMVKRARNYTDDV------EFSCEDAGRTPIADLARVVEAAINAGATTINIP 169 +E + R V A+ ++ F PI +A +VEA + G I++ Sbjct: 117 EESVARFGDCVTCAKEAGLEISGSISMAFGSPWDKEIPIGAVASIVEAYMAVGINEISLS 176 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 D G P + I + + + P K + +H H+ GL + N LA + +G Q + + Sbjct: 177 DASGMAFPPQVQEICAYMKKHYP---KNMWWLHFHNTRGLGMANILAGMQSGFTQFDSSF 233 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMP 280 G+G AGN + E+V+ + + T I+ + S+ V+Q+ P Sbjct: 234 AGVGGCPFVPGAAGNVATEDVL----NLCEESGIDTGIDFDKALEVSRRVAQLVAHP 286 >UniRef50_B0SA13 2-isopropylmalate synthase n=5 Tax=Leptospira RepID=B0SA13_LEPBA Length = 299 Score = 193 bits (490), Expect = 2e-47, Method: Composition-based stats. Identities = 67/311 (21%), Positives = 120/311 (38%), Gaps = 35/311 (11%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 ++V I + RDG Q + LS ++K + L G +E+ V I Sbjct: 2 EKVKITEVGPRDGLQNEKTILSTQDKFEFIKRLVESGAKHIELTSFV-------RKDRIP 54 Query: 63 RQVKNSRVCALARCV-EKDID--------VAAESLKVAEAFRIHTFIATSPMHIATKLRS 113 + + AL + KD+ E K+A + F ATS + Sbjct: 55 QMADAMELSALVLPLYAKDVQFSCLTPNTKGYEGAKLAGFNEVAVFTATSESFTKKNINM 114 Query: 114 TLDEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTIN 167 T+ E E + A+ V +C G+ P V E ++AGA I+ Sbjct: 115 TVKESFESFQPIFGLAKQDGIKVRGYISTVVACPYEGKIPPEKTLEVAERLLDAGAYEIS 174 Query: 168 IPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEG 227 + +T+G +P E ++S L +++P + ++ H HD G+A+ N+ A+ G R + Sbjct: 175 LGETIGVAVPNEIESLLSVLLKKIP---ISYLNCHFHDTYGMAIANTKQALSMGIRSFDS 231 Query: 228 AMNGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPI 281 + G+G AGN + E+++ + T IN + + SQ + + Sbjct: 232 SAGGLGGCPYAKGAAGNVATEDLVYFLSREG----YDTGINLDSLIQVSQFMEAKLDRSF 287 Query: 282 PANKAIVGSGA 292 + I Sbjct: 288 NSRTYIAKKNV 298 >UniRef50_O34873 Hydroxymethylglutaryl-CoA lyase yngG n=13 Tax=Bacteria RepID=HMGCL_BACSU Length = 299 Score = 192 bits (489), Expect = 2e-47, Method: Composition-based stats. Identities = 55/300 (18%), Positives = 116/300 (38%), Gaps = 29/300 (9%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVG---FPVSSPGDFESV 58 ++V I + RDG Q ++ ++K+ L R G+ +E+ P P +++ Sbjct: 4 PKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSYIEITSFVHPKWIPALRDAI 63 Query: 59 QTI--ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 + K AL E+ F++ S H + + Sbjct: 64 DVAKGIDREKGVTYAALVPN-----QRGLENALEGGINEACVFMSASETHNRKNINKSTS 118 Query: 117 EVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIPD 170 E + + A+ F C PI + R+ EA G + +++ D Sbjct: 119 ESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVIRLSEALFEFGISELSLGD 178 Query: 171 TVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMN 230 T+G P + ++ L R P I++H HD G A+ N + A+ G +G+ Sbjct: 179 TIGAANPAQVETVLEALLARFPA---NQIALHFHDTRGTALANMVTALQMGITVFDGSAG 235 Query: 231 GIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 G+G +GN + E+++ ++ +++ T + +++ ++ + + P+P+ Sbjct: 236 GLGGCPYAPGSSGNAATEDIVYMLEQ----MDIKTNVKLEKLLSAAKWIEEKMGKPLPSR 291 >UniRef50_D0Z8X0 Putative hydroxymethylglutaryl-CoA lyase n=1 Tax=Edwardsiella tarda EIB202 RepID=D0Z8X0_EDWTE Length = 312 Score = 192 bits (488), Expect = 3e-47, Method: Composition-based stats. Identities = 60/304 (19%), Positives = 126/304 (41%), Gaps = 34/304 (11%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + V + + + RDG Q ++ + + K+ I + R GV +EV VS + Sbjct: 11 LPASVTLTEVSPRDGFQNIEQWIPTETKINIVEGIFRSGVKNIEVTSFVSP-------KA 63 Query: 61 IARQVKNSRV--CALARCVEKDIDV--------AAESLKVAEAFRIHTFIATSPMHIATK 110 I + + V A+A D+++ AE +++ I+ SP+H Sbjct: 64 IPQMKDAAIVAEYAVAMAKNTDVNIMALIPNVKGAERALSCGIRKVNYIISASPLHNKKN 123 Query: 111 LRSTLDEVIERAIYMVKRARN----YTDDVEFSCEDAGRTPIADLARVVEAAINAGATTI 166 + T E E + K F C G+ P+ D+ ++ AA + G + Sbjct: 124 MNRTPQESFEALCELKKNFPEADVTLGVATAFGCPFQGKVPVDDVITLMRAARDIGINSF 183 Query: 167 NIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVE 226 + DT+G P + ++ + + +I +++H H+ G+A+ N AA+ G + E Sbjct: 184 TLCDTIGVANPRQVETLLHEVKKNFSDIQ---LALHLHNTHGMALANIYAAMLQGVDRFE 240 Query: 227 GAMNGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMP 280 A+ G+G AGN + E+++ + + +++ I+ ++ + + ++ Sbjct: 241 SAIGGLGGCPFAPGAAGNAATEDLVNMLN----RMEINSNIDLAKLLDVANQIRELVPCS 296 Query: 281 IPAN 284 I Sbjct: 297 ISGM 300 >UniRef50_A8WG57 Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2 n=47 Tax=root RepID=HMGC2_DANRE Length = 335 Score = 192 bits (488), Expect = 3e-47, Method: Composition-based stats. Identities = 59/296 (19%), Positives = 119/296 (40%), Gaps = 29/296 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP-----GDF 55 + V I + RDG Q + + + K+Q+ L + G+ V+E VSS D Sbjct: 39 LPVYVKIVEVGPRDGLQNEKEIVPTEVKIQLIDLLSQTGLPVIEATSFVSSKWVAQMADH 98 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 +V ++ + R L ++ ++ A A + F + S + ++ Sbjct: 99 TAVLKGIKRSPDVRYPVLTPNIQ-----GFQAAVAAGANEVAVFGSASETFSRKNINCSI 153 Query: 116 DEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIP 169 +E ++R +V A+ V C G+ + + +V + G +++ Sbjct: 154 EESLQRFEQVVSAAKQEGIPVRGYVSCALGCPYEGQVKPSQVTKVAKRLFELGCYEVSLG 213 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G A ++S + VP ++VH HD G A+ N L A+ G V+ ++ Sbjct: 214 DTIGVGTAGSMAEMLSDVLTEVPA---GALAVHCHDTYGQALPNILIALQMGVSVVDASV 270 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNM 279 G+G +GN S E+++ + L + T ++ ++ + + N Sbjct: 271 AGLGGCPFAKGASGNVSTEDLLYMLH----GLGIETGVDLLKVMEAGDFICKALNR 322 >UniRef50_Q8TB92 Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2 n=26 Tax=cellular organisms RepID=HMGC2_HUMAN Length = 370 Score = 192 bits (488), Expect = 3e-47, Method: Composition-based stats. Identities = 64/295 (21%), Positives = 114/295 (38%), Gaps = 29/295 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP-----GDF 55 + + V I + RDG Q + + K++ L + G+ V+EV VSS D Sbjct: 74 LPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQMADH 133 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 V Q R L ++ A A A I F A S + ++ Sbjct: 134 TEVMKGIHQYPGVRYPVLTPNLQGFHHAVA-----AGATEISVFGAASESFSKKNINCSI 188 Query: 116 DEVIERAIYMVKRARNYTD------DVEFSCEDAGRTPIADLARVVEAAINAGATTINIP 169 +E + + +VK AR+ C G + V + G I++ Sbjct: 189 EESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLG 248 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G P ++ + + +P ++VH HD G A+ N L A+ G V+ A+ Sbjct: 249 DTIGVGTPGSMKRMLESVMKEIP---PGALAVHCHDTYGQALANILTALQMGINVVDSAV 305 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICN 278 +G+G +GN + E++I + L ++T +N ++ + + N Sbjct: 306 SGLGGCPYAKGASGNVATEDLIYMLN----GLGLNTGVNLYKVMEAGDFICKAVN 356 >UniRef50_P35915 Hydroxymethylglutaryl-CoA lyase n=108 Tax=cellular organisms RepID=HMGCL_CHICK Length = 298 Score = 189 bits (481), Expect = 2e-46, Method: Composition-based stats. Identities = 61/296 (20%), Positives = 119/296 (40%), Gaps = 29/296 (9%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP-----GDFE 56 Q+V + + RDG Q ++ + K+++ L G+ V+E VS D Sbjct: 3 PQRVKVVEVGPRDGLQNEKSVVPTPVKIRLIDMLSETGLPVIEATSFVSPRWVPQMADHA 62 Query: 57 SVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 V ++ L ++ ++ A A + F A S + + +++ Sbjct: 63 EVMQGINKLPGVSYPVLTPNLK-----GFQAAVAAGAKEVSIFGAASELFTKKNINCSIE 117 Query: 117 EVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIPD 170 E +ER ++ AR + V C G A +A V + + G I++ D Sbjct: 118 ESLERFSEVMNAARAASIPVRGYVSCVLGCPYEGNISAAKVAEVSKKMYSMGCYEISLGD 177 Query: 171 TVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMN 230 +G P +++ + + VP ++VH HD G A+ N L A+ G V+ ++ Sbjct: 178 RIGIGTPGSMKEMLAAVMKEVP---VGALAVHCHDTYGQALANILVALQMGVSVVDASVA 234 Query: 231 GIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMP 280 G+G +GN + E+++ + L +HT ++ Q++ T + N Sbjct: 235 GLGGCPYAQGASGNVATEDLVYMLN----GLGIHTGVDLQKLMDTGTFICNALNRR 286 >UniRef50_C8WQC0 Pyruvate carboxyltransferase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WQC0_ALIAD Length = 301 Score = 189 bits (481), Expect = 2e-46, Method: Composition-based stats. Identities = 66/301 (21%), Positives = 125/301 (41%), Gaps = 29/301 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVG---FPVSSPG--DF 55 M ++V + + RDG Q ++ + K+++ L GV +EV P P D Sbjct: 1 MGERVWLREVGPRDGLQNEPGVIATEIKVELVERLMDAGVRFIEVSSFVHPKWIPQLADA 60 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + V R+ + AL A A+ +H F++ S H + T+ Sbjct: 61 DEVFARIRRRPGVELSALVPNERGLARALA-----AKVDAVHVFMSASESHNLKNINKTI 115 Query: 116 DEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIP 169 + +++ A+ V F C G+ P++ + VVE G + + Sbjct: 116 ADTYPVLRPVIEGAKAEGLVVRGYVSTVFGCPYEGKVPVSQVLSVVERLFELGVDEVALG 175 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G +P + A ++ + VP +S+H HD G+A+ N A AG R+ +G++ Sbjct: 176 DTIGVAVPTQVAEVVREVERIVP---LDRVSLHFHDTRGMAIANMYAGFAAGVRRFDGSI 232 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 G+G +GN ++E+V+ + ++V T I + + N P+ + Sbjct: 233 GGLGGCPYAPGASGNVAMEDVL----YLFNGMDVETGIEAERYLDVVAWLESKLNKPLAS 288 Query: 284 N 284 + Sbjct: 289 H 289 >UniRef50_A8MEN7 Pyruvate carboxyltransferase n=1 Tax=Alkaliphilus oremlandii OhILAs RepID=A8MEN7_ALKOO Length = 306 Score = 189 bits (481), Expect = 2e-46, Method: Composition-based stats. Identities = 69/307 (22%), Positives = 124/307 (40%), Gaps = 35/307 (11%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + + V I + RDG Q ++ ++ ++K+ I L +E+G VS + Sbjct: 3 IPKSVEILEVCPRDGFQNVKDFIATEDKIAIVERLIDANFKRIELGSFVSP-------KA 55 Query: 61 IARQVKNSRVCALAR--CVEKDID--------VAAESLKVAEAFRIHTFIATSPMHIATK 110 I + V A A+ V++DI ES A +I I+ S H Sbjct: 56 IPQMADTKEVVAAAKQYAVDQDIKFVALVPNARGVESAIAAGVDQITYVISASESHNKAN 115 Query: 111 LRSTLDEVIERAIYMVKRARN-----YTDDVEFSCEDAGRTPIADLARVVEAAINAGATT 165 + T+ E +E+ ++K + F C I + + + A + G Sbjct: 116 VNRTVAESMEQYEALIKEYKGDIDFRLGLATTFGCPFGDEVKIERIQEMCKWAFDLGTVE 175 Query: 166 INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQV 225 I + DTVG P + + ++ L V +H HD GLA+ N+LAA+ G + Sbjct: 176 ILMADTVGLGNPKKVSEVMRTL---VNEFGPEKFVMHLHDTRGLALANTLAAMQYGITKF 232 Query: 226 EGAMNGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNM 279 E A G+G +GN + E++ + + + T I ++++ QL+ N Sbjct: 233 ESATGGLGGCPFAPGASGNAATEDLYYMLSE----MGIETNIEIEKVYEAIQLIKDKVNT 288 Query: 280 PIPANKA 286 I ++ A Sbjct: 289 TIVSHLA 295 >UniRef50_O81027 Hydroxymethylglutaryl-CoA lyase, mitochondrial n=76 Tax=cellular organisms RepID=HMGCL_ARATH Length = 468 Score = 187 bits (476), Expect = 7e-46, Method: Composition-based stats. Identities = 61/297 (20%), Positives = 120/297 (40%), Gaps = 29/297 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP-----GDF 55 + + V I + RDG Q + + K+++ L G+ V+E VS D Sbjct: 164 IPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIQRLVSSGLPVVEATSFVSPKWVPQLADA 223 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + V + +R+ L ++ ++ A A + F + S + + T+ Sbjct: 224 KDVMDAVNTLDGARLPVLTPNLK-----GFQAAVSAGAKEVAIFASASESFSLSNINCTI 278 Query: 116 DEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIP 169 +E + R + A+ ++ V C G + +A VV+ + G I++ Sbjct: 279 EESLLRYRVVATAAKEHSVPVRGYVSCVVGCPVEGPVLPSKVAYVVKELYDMGCFEISLG 338 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G P ++ + VP ++VH HD G A+ N L ++ G V+ ++ Sbjct: 339 DTIGIGTPGSVVPMLEAVMAVVPA---DKLAVHFHDTYGQALANILVSLQMGISIVDSSI 395 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMP 280 G+G +GN + E+V+ + L VHT ++ ++ +S+ P Sbjct: 396 AGLGGCPYAKGASGNVATEDVVYMLN----GLGVHTNVDLGKLIAAGDFISKHLGRP 448 >UniRef50_A8FDY7 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacillus pumilus RepID=A8FDY7_BACP2 Length = 302 Score = 187 bits (475), Expect = 9e-46, Method: Composition-based stats. Identities = 64/301 (21%), Positives = 119/301 (39%), Gaps = 29/301 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVG---FPVSSPGDFES 57 + ++V+I + RDG Q L EK + L + +EV P P ++ Sbjct: 3 LPKRVLIREVGPRDGLQNESTWLDTSEKQRWIELLTAARLPYIEVTSFVHPKWVPALKDA 62 Query: 58 VQTIARQVKNSRV-CALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 + K + A EK + E+ A FI++S H + ++ Sbjct: 63 KELAQSLHKKGDITYAALIPNEKGLAHFFEANLDTGA----MFISSSETHNKKNMNQSIQ 118 Query: 117 EVIERAIYMV-------KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIP 169 E + M K R Y V F C + P+ + R+ E ++ G I++ Sbjct: 119 ETLPVIKQMTADLKAAGKHTRAYISTV-FGCPYEHQVPMDQVLRLTEMLLSYGIDEISLG 177 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G P + + L ER P I++H HD G+ + N A+ AG + + Sbjct: 178 DTIGEAHPLQVERRLDILLERFPA---DKIALHFHDTKGMGLANIYTALKAGITIFDASS 234 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 G+G +GN + E+V+ ++ + T IN + + ++ + + +P+ Sbjct: 235 GGLGGCPYAPGSSGNVATEDVVHMLQKLG----IDTNINFPALIKAAEWIETKVDRTLPS 290 Query: 284 N 284 + Sbjct: 291 H 291 >UniRef50_Q5WKL8 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillaceae RepID=Q5WKL8_BACSK Length = 309 Score = 187 bits (475), Expect = 1e-45, Method: Composition-based stats. Identities = 64/293 (21%), Positives = 114/293 (38%), Gaps = 27/293 (9%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP-----GDFESVQ 59 V I + RDG Q Q LSV++K+++ R G+ +E V+ D E V Sbjct: 13 VEICEVGPRDGLQNEQVRLSVEQKIEMMEHAARSGISKIEAVSFVNKKLVPAMADAEEVM 72 Query: 60 TIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + + R+ LA I A ++ +H I+ S T+ E + Sbjct: 73 AAWHRREGVRIAGLA-LSRSGITRALQT----PIDVLHITISASDAFNKRNANKTVAEGL 127 Query: 120 ERAIYMVKRARNY-----TDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGY 174 + +V A + F C +G + + V E+ + AGAT + + DT G Sbjct: 128 SDLLPVVGEASTHLPVVTVISTSFGCPFSGDVQMETVFSVCESFLKAGATEMVLADTTGM 187 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 P + A + G Y + +H H+ GL + N++A AG R+ + A+ G+G Sbjct: 188 ANPRQVAETVRGFYRTFGE--DIPLGLHFHNTRGLGLANAVAGYDAGVRRFDSAVGGLGG 245 Query: 235 ------RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPI 281 GN E+++ + + T + + +Q V + + Sbjct: 246 CPFAPKATGNICTEDLVHMFHE----MGIDTGTDLDGLITLAQQVEKWMGKRL 294 >UniRef50_A9F2G5 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacteria RepID=A9F2G5_SORC5 Length = 328 Score = 186 bits (473), Expect = 2e-45, Method: Composition-based stats. Identities = 61/298 (20%), Positives = 117/298 (39%), Gaps = 29/298 (9%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP-----GDFE 56 + +V I++ + RDG Q A + ++ K ++ AL G+ +E+ VS D E Sbjct: 25 ADEVSIYEVSPRDGLQNESAMIPIEGKRRLIAALVGAGLRRIEITSFVSPKWVPQLADAE 84 Query: 57 SVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 + + AL E I F++ S H + ++D Sbjct: 85 ELARTLPAERGVTFSALCPNAR-----GLERALAVGLREIAVFLSASEAHNRANINKSID 139 Query: 117 EVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIPD 170 + + +V AR V + C G A + R+ E I+ G +++ D Sbjct: 140 DTLSVFSEIVPPAREAGLAVRAYVSTVWGCPYEGDVDPARVVRIAERLIDLGCYQVSLGD 199 Query: 171 TVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMN 230 T+G P + I+ + +P ++H HD G A+ N L + G R + ++ Sbjct: 200 TIGVGTPRQTHDIVRRFLDAMP---PERFALHLHDTRGTALANILVGLELGVRDFDASVA 256 Query: 231 GIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIP 282 G+G AGN + E+++ + + V T ++ ++ + Q+ P+P Sbjct: 257 GVGGCPYAPGAAGNMATEDLVFMLH----GMGVRTGVDLDKVIEAGNVAEQVIGRPLP 310 >UniRef50_C6JJQ3 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria RepID=C6JJQ3_FUSVA Length = 303 Score = 186 bits (473), Expect = 2e-45, Method: Composition-based stats. Identities = 69/304 (22%), Positives = 124/304 (40%), Gaps = 29/304 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGF---PVSSPGDFES 57 + ++V I + RDG Q ++ + K KL+I +LE G + +E+ P P +S Sbjct: 3 LPEKVQIVEVGPRDGFQNIKTFIETKHKLEIIDSLEEAGCNKIEITSFVNPKWIPQMVDS 62 Query: 58 VQTIARQVKNS----RVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRS 113 + VK + V L +K I+ A S A I I+ S H + Sbjct: 63 KEICETCVKKNERKYEVIVLCP-NKKGIENAISS----GAEVISVVISVSEAHNKANVNR 117 Query: 114 TLDEVIERAIYMVKRARN----YTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIP 169 T++E + MV + N F C ++ ++E A G I + Sbjct: 118 TVEESFKELEEMVYKYPNMKFRLDLATVFGCPFGEEIKPERVSELIEKAKKIGVKEIMLA 177 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DTVG P I+ + E+V I +H HD G+ + N L A+ G E ++ Sbjct: 178 DTVGLGNPVLVEKILKQVKEQV---GTENIILHIHDTRGMGLANMLVALQLGYSIFETSI 234 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 G+G AGN + E+ + + + ++ I+ ++++ T L+ Q ++ + Sbjct: 235 GGLGGCPFAPGAAGNVATEDFVNMLN----GMGINHNIHLEKLYHTLDLIDQYVDVNLNN 290 Query: 284 NKAI 287 + Sbjct: 291 SHMY 294 >UniRef50_C8SJR8 Homocitrate synthase n=1 Tax=Mesorhizobium opportunistum WSM2075 RepID=C8SJR8_9RHIZ Length = 354 Score = 186 bits (473), Expect = 2e-45, Method: Composition-based stats. Identities = 84/290 (28%), Positives = 122/290 (42%), Gaps = 42/290 (14%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 MS QV + DTTLRDGEQA + +V EKL+IA +L GV +E+G P + Sbjct: 1 MSSQVFLKDTTLRDGEQAPGVAFTVAEKLEIAESLAAAGVPEIEIGTPAMGADE------ 54 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 + + R+ A R D++ A ES A ++ + S + +ATKL ++ Sbjct: 55 -VARSLSVRLTAWCRMTSPDLEAAIESGVRA----VNLSFSASNIQLATKLGLDRAGALQ 109 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 +MV RA V CEDA R L RV+ A AGA + + DT G PF Sbjct: 110 LIEHMVGRAAASGSSVAVGCEDASRADRDHLGRVIMTAARAGARRVRLADTAGVLDPFST 169 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 +++ LAA+ AGAR + G+ ER GN + Sbjct: 170 FELVAQ----------------------------LAAIRAGARHASVTLLGLSERGGNAA 201 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGS 290 L + + H I+ + + V+Q P A K IVG+ Sbjct: 202 L---EEVAAALAVLQHAHAGIDLTALPALAAKVAQASRRPTAATKPIVGA 248 >UniRef50_D1WUS8 2-isopropylmalate synthase n=2 Tax=Streptomyces RepID=D1WUS8_9ACTO Length = 359 Score = 185 bits (471), Expect = 2e-45, Method: Composition-based stats. Identities = 101/372 (27%), Positives = 158/372 (42%), Gaps = 22/372 (5%) Query: 18 ALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP--GDFESVQTIARQVKNSRVCALAR 75 S + IA L R GV+++EVG VS P D E V V R L Sbjct: 1 MAGVEFSPADAAAIADLLVRTGVELVEVGM-VSGPDSKDAELVLATHEAVTPERSMTLVV 59 Query: 76 CV-EKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLR-STLDEVIERAIYMVKRARNYT 133 + + A + + I I TS H KL ++ + A +++A+ Sbjct: 60 VRDRRQVARALDEAERLGVRHIMYSIPTSEEHAQLKLDSASPKFLQALARSAIQQAKERG 119 Query: 134 DDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPN 193 V FS ED RTP L V A AGA + +TV Y P++ +I+ L Sbjct: 120 FHVTFSGEDGARTPRERLVPYVAAGFAAGADRFRLAETVAYLSPWQMEEVIADL----TA 175 Query: 194 IDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKD 253 ID + I +H+H+ LGLAV NSLAAV AGAR + + GIGER GN L E++ +++V Sbjct: 176 IDGSEIEIHSHNMLGLAVANSLAAVRAGARWISATVGGIGERGGNAPLAELLTSLRVLHG 235 Query: 254 ILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEI 313 T + + S++ + + AFA+ G L + + YE Sbjct: 236 ----DTRFDLTHLTELSRIALRGAGLGDAFQSGPTTPHAFAYE----LPGQLSHPQAYET 287 Query: 314 MTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQ-VFD 372 + E +G N +L + +R A V+ + + G +D + ++ G+ + D Sbjct: 288 LPAELVG-NSRELRVRTRLTTALVRWALTDSGLDVD---VDAFTPWLAERQERDGRPLLD 343 Query: 373 YDLEALAFIGKQ 384 D A + + Sbjct: 344 RDTIRKAAVDFR 355 >UniRef50_UPI00015B4E2A PREDICTED: similar to hydroxymethylglutaryl-coa lyase n=1 Tax=Nasonia vitripennis RepID=UPI00015B4E2A Length = 327 Score = 185 bits (469), Expect = 4e-45, Method: Composition-based stats. Identities = 58/288 (20%), Positives = 109/288 (37%), Gaps = 27/288 (9%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP-----GDFESVQ 59 V I + RDG Q ++ L + K+++ L + G+ +EV VS D V Sbjct: 27 VRIVEVGPRDGLQNIRKVLPTETKIELINRLSQTGLRSVEVTSFVSPKWVPQMADSAEVY 86 Query: 60 TIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + N L + K +D A + + F A S + ++ E + Sbjct: 87 QGVEKNPNVEYSVLVPNL-KGLDKALK----LGVKEVVLFTAASETFNQKNINCSIAESL 141 Query: 120 ERAIYMVKRARNY------TDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVG 173 + + K + C G ++A V EA ++ G + + DT+G Sbjct: 142 KNCKEITKICKEKKIKARAVISCIAGCPYEGEIKPVNVANVAEALLDMGCYEVGLGDTIG 201 Query: 174 YTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIG 233 P + A + L + D +VH HD G A+ N + G R + ++ G+G Sbjct: 202 VATPKKMAHLFEELKKMTGG-DVWRFAVHCHDTYGQAIANIYECLRQGIRVFDSSVAGLG 260 Query: 234 ------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQ 275 +GN S E+++ + T ++ ++ + Q +S+ Sbjct: 261 GCPYAPGASGNVSTEDLVYLLH----GEGFETGVDLDKLIQVGQFISE 304 >UniRef50_D2VQL9 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2VQL9_NAEGR Length = 422 Score = 185 bits (469), Expect = 4e-45, Method: Composition-based stats. Identities = 64/297 (21%), Positives = 119/297 (40%), Gaps = 31/297 (10%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP-----GDF 55 M V I + RDG Q + + K+ + L G+ +EV VS GD Sbjct: 75 MPSFVKIVEVGPRDGLQNEKKLVPTNVKISLIDKLTEAGLPSVEVTSFVSPKWVPQMGDN 134 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 V T ++ + + L V+ E A + F+A S + T+ Sbjct: 135 FDVFTGIKRREGTAYPVLTPNVK-----GLEQALEAGVKEVAIFLAASDAFSMKNINCTV 189 Query: 116 DE-------VIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINI 168 +E V+E AI + R Y V C +G +A+V + G +++ Sbjct: 190 EESFKRYDQVMELAIKNDLKIRGYVSCVA-GCPYSGYVSPETVAQVSYRLLKMGCYEVSL 248 Query: 169 PDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGA 228 DT+G P + ++ + +++P I+VH H+ G A+ N L ++ G V+ + Sbjct: 249 GDTIGVGTPGSVSMLLHQVCKKIPT---GQIAVHFHNTYGQALSNILTSLQFGVETVDSS 305 Query: 229 MNGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNM 279 + G+G +GN S E+V+ + + ++T ++ ++ +S N Sbjct: 306 VAGLGGCPYAKGASGNISTEDVVYMLH----GMGINTGVDLDKLIDAGDYISTYLNR 358 >UniRef50_D1TMW3 Hydroxymethylglutaryl-CoA lyase n=1 Tax=Burkholderia sp. CCGE1002 RepID=D1TMW3_9BURK Length = 338 Score = 184 bits (468), Expect = 6e-45, Method: Composition-based stats. Identities = 59/309 (19%), Positives = 118/309 (38%), Gaps = 30/309 (9%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPG-----DFES 57 + V I D +RDG Q + EK+ + + G++ +E S+ D E+ Sbjct: 10 ESVWINDVVMRDGLQMEPVFVPTSEKVALIDEIGHCGLNRIEATSFTSAKAIPALSDAEA 69 Query: 58 VQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 V +V R AL AE ++ ++ S H R T + Sbjct: 70 VMHEIERVPGVRYAALVLNRR-----GAERALECGVDELNLGVSASETHNLANTRMTRAQ 124 Query: 118 VIERAIYMVKRARNY-----TDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTV 172 + + + R+ + F C G I + + + AG I + DT Sbjct: 125 AVRALLDITAFCRDRLAIGVSIATAFGCPMEGAIDIDSVLDIGNQFVAAGVRGITLCDTT 184 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G P + + L R I+ +++H H+ G+ + N +A + AG R + ++ G+ Sbjct: 185 GMANPRQVKAVCGALAARWRGIE---LTLHLHNTRGMGLANVVAGLDAGIRHFDASLGGL 241 Query: 233 G------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKA 286 G +GN E+++ + D + T ++ + + ++ + + +P Sbjct: 242 GGCPFAPGASGNICTEDLVHML----DAMGYATGVDLERLIACARRMPGLVGHGVPGQ-- 295 Query: 287 IVGSGAFAH 295 + +GA+ H Sbjct: 296 VQHAGAWDH 304 >UniRef50_Q28KR2 Hydroxymethylglutaryl-CoA lyase n=5 Tax=Alphaproteobacteria RepID=Q28KR2_JANSC Length = 319 Score = 184 bits (468), Expect = 7e-45, Method: Composition-based stats. Identities = 58/303 (19%), Positives = 117/303 (38%), Gaps = 31/303 (10%) Query: 1 MSQ--QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGF---PVSSPGDF 55 M + V + + RDG Q+ + + K++IA A+ G+ ++V P + P Sbjct: 8 MPEGSHVTVCEVGPRDGFQSEKTFIPTARKIEIANAMFAAGLRHIQVTSFVSPRAVPQLA 67 Query: 56 ESVQTIA--RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRS 113 ++ + IA + + V AL ++ AE A +HT ++ S H + Sbjct: 68 DAAKLIAGLDRPDGAVVSALIPNLK-----GAERAAAAGVDAVHTVVSASETHNLKNVNR 122 Query: 114 TLDEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTIN 167 +D+ + + K VE F C G P +AR+ + GA ++ Sbjct: 123 PIDQSLADFEDVAKLMHREGIVVEGGMATAFGCPFEGVVPPEQVARIARRYQDLGAKRVS 182 Query: 168 IPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEG 227 + DT G P + + P ++ I +H H+ G+ + +A + G + Sbjct: 183 LGDTTGMATPTTVRAAVRAIRAEAPGVE---ICLHFHNTRGVGLACVMAGLAEGVSYFDA 239 Query: 228 AMNGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPI 281 A+ G+G GN E+++ ++ T ++ + + + L + + Sbjct: 240 AIGGLGGCPFAAGATGNICTEDLVYLLEESG----YRTGVDLEALISVAGLAQETIGRDL 295 Query: 282 PAN 284 P Sbjct: 296 PGQ 298 >UniRef50_A3JC95 Pyruvate carboxyltransferase n=5 Tax=Gammaproteobacteria RepID=A3JC95_9ALTE Length = 308 Score = 183 bits (466), Expect = 1e-44, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 131/298 (43%), Gaps = 35/298 (11%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 ++ I + RDG Q+ +LSV+++L + AL ++G+ +E G VS + + + Sbjct: 2 KIRINEVGPRDGLQSQGKTLSVEDRLSLIQALVKVGLKNVEAGSFVSP-------KAVPQ 54 Query: 64 QVKNSRVCALARCVEKDIDVAA--------ESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + AL + A E A A ++ ++ + +R +L Sbjct: 55 MAGTDDLFALLP-ERSAVRYAGLVPNMKGYELAVAAGANVVNVVLSVTETMNQKNIRMSL 113 Query: 116 DEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIP 169 + +E +++R R +V+ F C G A +AR+ + AGA+ I I Sbjct: 114 PQTVEVCTAIIERGRCEGVEVQAYLAVAFECPFEGLVEPAVVARLAKRLEQAGASKIIIA 173 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G P +++G+ + + I+S H HD G+A+ N AA+ G R+ + ++ Sbjct: 174 DTIGAANPEHVRRLLNGV---ISEVGSDILSCHFHDTRGIALANITAALDHGIREFDTSI 230 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPI 281 G+G GN + E+V++ + + T IN ++ L Q+ +P+ Sbjct: 231 GGLGGCPFSPGATGNVATEDVVLLLNS----MGHDTGINPFDLVPVVCLAEQLTGVPL 284 >UniRef50_C1BAX9 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Rhodococcus RepID=C1BAX9_RHOOB Length = 307 Score = 183 bits (465), Expect = 1e-44, Method: Composition-based stats. Identities = 63/305 (20%), Positives = 120/305 (39%), Gaps = 27/305 (8%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPV---SSPGDFESV 58 Q+V I + RDG Q + +K+++ AL R G +EV V P + V Sbjct: 4 PQRVQIREVGPRDGFQNEPEHIPTDDKVRLINALGRAGFTRIEVASFVRPDVIPQLADGV 63 Query: 59 QTIAR--QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 + ++R +++ L K +D A + + + F++ S H + T+D Sbjct: 64 EVLSRIEVPDETKLMVLVP-NSKGLDNALK--VRDKFHEVAIFVSASETHNKKNVNRTVD 120 Query: 117 EVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIPD 170 E + M KR D F C G+ + + + E AGAT I D Sbjct: 121 ETMADNDVMAKRIVAEGLDCAAVIATSFGCPFEGKVDLTRVLDLAERFAEAGATEIGFGD 180 Query: 171 TVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMN 230 T G P + + +R+P ++ ++ H H+ G + N+ AA+ AG E + Sbjct: 181 TTGMCNPAYASEFFAAALDRLPGVE---VTAHFHNTRGQGLANAYAALEAGCASFESSFG 237 Query: 231 GIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 +G GN + E+++ + V T ++ + ++ + + ++ Sbjct: 238 ELGGCPVPAGSTGNIATEDLVSMFHE----MGVETGLDLPRVIEAAREAQAVLGRKLTSH 293 Query: 285 KAIVG 289 + G Sbjct: 294 SIVAG 298 >UniRef50_A9FUN7 Putative 2-isopropylmalate synthase n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9FUN7_SORC5 Length = 402 Score = 182 bits (463), Expect = 3e-44, Method: Composition-based stats. Identities = 76/297 (25%), Positives = 131/297 (44%), Gaps = 13/297 (4%) Query: 2 SQQVIIFDTTLRDGEQALQ-ASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 ++ V + D TLRDG Q + + S K+++ A+ +GVDV+ +G P + P F+ Sbjct: 106 ARPVEVLDETLRDGIQGVSIVNPSRARKIELLHAMASVGVDVVNLGMPATGPRQFDDACL 165 Query: 61 IARQVKNSRVC----ALARCVEKDIDVAAESLKVAEAFR-IHTFIATSPMHIATKLRSTL 115 +AR++ SR+ A AR + D+D A + A A ++ FI +SP+ Sbjct: 166 LAREIVASRLPLGLTAAARTLAADVDEVARVAERAGAPIMVYAFIGSSPI-RHFVEGWGP 224 Query: 116 DEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYT 175 D + + A EDA R+P L + AA++AGA + + DT G+ Sbjct: 225 DFLARSVDEAGRAAAAAGLPFCLVAEDATRSPPDMLRTLFRAAVDAGAARLCLCDTTGHV 284 Query: 176 MPFEFAGIISGLYERVPNIDKAIIS--VHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIG 233 P +++ + + I H H+D GL + +L AV +G +V G+G Sbjct: 285 TPPGVEALVAFARRELGALGATGIELDWHGHNDRGLGLAAALWAVASGVERVHATALGVG 344 Query: 234 ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGS 290 ER GN LE ++ + L + + + S+ P+ + I G+ Sbjct: 345 ERTGNTCLELLVDNL----GRLGARPPVPRERLVAYCAAASRALAWPVTPDHPIAGA 397 >UniRef50_A4X0W1 Pyruvate carboxyltransferase n=3 Tax=Actinomycetales RepID=A4X0W1_SALTO Length = 303 Score = 182 bits (462), Expect = 3e-44, Method: Composition-based stats. Identities = 63/299 (21%), Positives = 118/299 (39%), Gaps = 30/299 (10%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVG---FPVSSPG--DF 55 M V I + RDG Q + + K+++ AL R GV +E P + P D Sbjct: 1 MPGFVSIREVGPRDGLQNE-EPIPTEAKVRLLDALSRTGVGRIEAVSFVHPKAIPQMADA 59 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + V A Q + R AL A +L A I ++ S H + + Sbjct: 60 DEVWRRAEQTEGVRYSALVPNTRG----AHRAL-AAGFTEIEVVVSASDTHNRRNVNRST 114 Query: 116 DEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIP 169 +E ++ +V+ + E F C G +A +V+ + GA + Sbjct: 115 EESLDDIAELVELLHHAGARAEVIIATSFGCPYEGDIDPVRVAGIVDRVVRDGADRVAFG 174 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT G P +++ + +R ++ + +H H+ G A+ N L A+ G + + ++ Sbjct: 175 DTTGMATPRRVRELVTAVRDRDAHLP---LLLHFHNTRGAALANLLTAIELGVTEFDASV 231 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIP 282 G+G +GN + EE + + + V T I+ + ++L ++ +P Sbjct: 232 GGLGGCPYAPGASGNLATEEAVHLLH----DMGVDTGIDLAALIEVAELAEELVGRSLP 286 >UniRef50_B4BIN3 Pyruvate carboxyltransferase n=1 Tax=Geobacillus sp. G11MC16 RepID=B4BIN3_9BACI Length = 300 Score = 182 bits (461), Expect = 4e-44, Method: Composition-based stats. Identities = 63/294 (21%), Positives = 122/294 (41%), Gaps = 30/294 (10%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSS-----PGDF 55 M V I D + RDG Q Q +S ++K + L + + +E V D Sbjct: 1 MP-DVQIIDVSPRDGLQNEQVIVSSEKKRMLIEMLVKSNIRKIEATSFVHPLKVPQMADA 59 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 E V + ++ + AL ++ + K + I+ A + + ++ Sbjct: 60 EQVLKLCEELSEIELVALIPNLK-----GFQRAKQTKISEINWVTAATETFNYKNIGMSI 114 Query: 116 DEVIERAIYMVKRARNYTDD------VEFSCEDAGRTPIADLARVVEAAINAGATTINIP 169 ++ + +V+ +R V F C G+ + +VE AI AGA I I Sbjct: 115 EDNFAQFKQLVQESRTLNITICFSIAVSFGCPYEGKVSPVKVISLVERAIEAGANRIGIA 174 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G P + +++ + +I I++H HD G+ + N+ AA+ AG + E + Sbjct: 175 DTIGIATPKQVKELLTEVLHIAKSIP---IAIHLHDTRGMGLANAYAALEAGVKIFETSA 231 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQIC 277 +GIG AGN + E+++ + + V T I+ +++ + + + Sbjct: 232 SGIGGCPFAPGAAGNLATEDLVYMFE----RMGVKTGIDFEKLLDAADFAASLT 281 >UniRef50_C7MUV0 Hydroxymethylglutaryl-CoA lyase n=5 Tax=cellular organisms RepID=C7MUV0_SACVD Length = 314 Score = 182 bits (461), Expect = 4e-44, Method: Composition-based stats. Identities = 69/301 (22%), Positives = 119/301 (39%), Gaps = 28/301 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVG---FPVSSPG--DF 55 + ++V I++ RDG Q + ++ V KL+ L G+ +E P P D Sbjct: 18 LPERVTIWEVGPRDGLQNERTTVPVDVKLEFLDRLADAGLTTVEATSFVHPKWVPQLADA 77 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 E + R+ R L E+ +D A A + F + + L S L Sbjct: 78 EELLARLRRRDGVRYPVLVP-NERGLDRAL----AAGVTHVAVFASATESFARRNLNSGL 132 Query: 116 DEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIP 169 D ++ RAR DV F G P + V ++AG T +++ Sbjct: 133 DAQFAMFEPVIARAREAGLDVRGYVSMCFGDPWEGIVPTEQVVTVGRRLLDAGCTQLSLG 192 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G ++ E + A ++VH HD G A+ N+LAA+ G V+ + Sbjct: 193 DTIGVATAAAVERLLDAFIE--GGVAIADLAVHFHDTYGQALANTLAALRKGVTTVDASA 250 Query: 230 NGIGE------RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 G+G GN + E+++ + D L V ++ + TS+ +S+ P+ Sbjct: 251 GGLGGCPYAESATGNLATEDLVWLL----DGLGVEHGVDLDALVETSRWMSRQLGRSSPS 306 Query: 284 N 284 Sbjct: 307 R 307 >UniRef50_Q15RQ1 Hydroxymethylglutaryl-CoA lyase n=89 Tax=Bacteria RepID=Q15RQ1_PSEA6 Length = 305 Score = 181 bits (460), Expect = 5e-44, Method: Composition-based stats. Identities = 68/312 (21%), Positives = 124/312 (39%), Gaps = 36/312 (11%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVG---FPVSSPGDFES 57 + +V I + RDG Q +AS+ + K+ + AL + G+ ++E G P P +S Sbjct: 5 LPSKVKIVEVGPRDGLQNEKASIDLVTKVTLIEALAKSGLSMIETGSFVSPKWVPQMADS 64 Query: 58 VQ--TIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 Q + AL + E+ A A + F + S + ++ Sbjct: 65 AQVFAAINRQDTVIYSALTPNL-----TGFEAALEAGADEVAIFGSASESFSQKNINCSI 119 Query: 116 DEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIP 169 E + R ++ A+ V C G A++A V + G I++ Sbjct: 120 AESLARFEPVIAAAKAKNIKVRGYVSCVLGCPYEGEIAPANVASVAKTLFEMGCYEISLG 179 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G P +++ + + VP ++VH HD G A+ N L A+ G V+ A+ Sbjct: 180 DTIGVGTPIATQIMLNAVLDVVP---LCAVAVHFHDTYGQALANILVALQLGINVVDSAV 236 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNM---- 279 G+G +GN + E+V+ + + + T I+ + + Q V + Sbjct: 237 AGLGGCPYAKGASGNVATEDVVYMLH----GMGIATGIDLSMLAKAGQDVCTKLGINSVS 292 Query: 280 ---PIPANKAIV 288 + ANKA+ Sbjct: 293 KVANVYANKALT 304 >UniRef50_D0MGG7 Pyruvate carboxyltransferase n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MGG7_RHOM4 Length = 311 Score = 181 bits (459), Expect = 6e-44, Method: Composition-based stats. Identities = 59/302 (19%), Positives = 113/302 (37%), Gaps = 29/302 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVG---FPVSSPG--DF 55 + + I + RDG Q + + K+ + L GV ++V P P D Sbjct: 3 LPESASICEVGPRDGFQYETTFIPTERKVAVIERLVEAGVRRIQVTSFVHPKWVPQMADA 62 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 E V + LA V+ E A + IAT H T+ Sbjct: 63 EEVCRRLPDRDDVIFSGLALNVK-----GVERAHAAGLRYVDLSIATHDEHSLANANMTV 117 Query: 116 DEVIERAIYMVKRARNY------TDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIP 169 E + +A M++ A +Y F + G TP+ + + ++ G + ++ Sbjct: 118 AEAVRQAEAMIRLAHHYDMQPQLGLQTVFGYKQPGDTPLQRIRELARRFVDLGLESFSLA 177 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT G P + + + E I + +H HD G+ + N LAA+ G + + ++ Sbjct: 178 DTTGMAHPVQIQEYVEAVRE---EIGDTPLVLHLHDTRGMGLANVLAALQCGVTRFDTSL 234 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 G+G GN + E+ + ++ + V T I+++ + + + +P Sbjct: 235 GGLGGCPFIPGATGNIATEDTVYMLEA----MGVRTGIDYRRVAELALELEAFLGKELPG 290 Query: 284 NK 285 + Sbjct: 291 RQ 292 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_B2VDA7 2-isopropylmalate synthase n=4 Tax=Enterobacteri... 578 e-163 UniRef50_A6T4L9 2-isopropylmalate synthase n=327 Tax=Bacteria Re... 575 e-162 UniRef50_Q3AEQ5 2-isopropylmalate synthase n=42 Tax=Bacteria Rep... 556 e-157 UniRef50_B8DM91 2-isopropylmalate synthase n=31 Tax=Bacteria Rep... 538 e-151 UniRef50_B7GH19 2-isopropylmalate synthase n=98 Tax=cellular org... 537 e-151 UniRef50_B8J4F8 2-isopropylmalate synthase n=3 Tax=Desulfovibrio... 536 e-150 UniRef50_Q7UI51 2-isopropylmalate synthase n=1 Tax=Rhodopirellul... 535 e-150 UniRef50_A4YZ76 2-isopropylmalate synthase n=131 Tax=root RepID=... 533 e-150 UniRef50_A7Z7B8 2-isopropylmalate synthase n=11 Tax=Bacillales R... 531 e-149 UniRef50_Q2YBW0 2-isopropylmalate synthase n=2 Tax=Bacteria RepI... 530 e-149 UniRef50_P48571 2-isopropylmalate synthase n=3 Tax=Buchnera aphi... 530 e-149 UniRef50_A3PDH0 2-isopropylmalate synthase n=42 Tax=cellular org... 529 e-148 UniRef50_A8FFW5 2-isopropylmalate synthase n=224 Tax=Bacilli Rep... 528 e-148 UniRef50_D2M1E9 2-isopropylmalate synthase n=1 Tax=Bacillus cell... 527 e-148 UniRef50_Q2IUT4 2-isopropylmalate synthase n=119 Tax=Bacteria Re... 527 e-148 UniRef50_Q72JC9 2-isopropylmalate synthase n=4 Tax=Thermaceae Re... 522 e-146 UniRef50_A3DF94 2-isopropylmalate synthase n=3 Tax=Clostridium t... 515 e-144 UniRef50_Q9C550 2-isopropylmalate synthase 2, chloroplastic n=59... 512 e-143 UniRef50_A6EER4 2-isopropylmalate synthase n=3 Tax=Sphingobacter... 511 e-143 UniRef50_Q5F8D4 2-isopropylmalate synthase n=73 Tax=cellular org... 507 e-142 UniRef50_B8J824 2-isopropylmalate synthase n=7 Tax=Bacteria RepI... 506 e-142 UniRef50_B6YRN0 2-isopropylmalate synthase n=1 Tax=Candidatus Az... 506 e-142 UniRef50_A6LDN1 2-isopropylmalate synthase n=6 Tax=Bacteria RepI... 502 e-141 UniRef50_C7JAV8 2-isopropylmalate synthase n=8 Tax=Acetobacter p... 498 e-139 UniRef50_B3DX88 2-isopropylmalate synthase n=12 Tax=Bacteria Rep... 496 e-139 UniRef50_Q58787 (R)-citramalate synthase n=5 Tax=Methanococcales... 491 e-137 UniRef50_O27525 2-isopropylmalate synthase 2 n=22 Tax=Archaea Re... 491 e-137 UniRef50_D0MYD7 2-isopropylmalate synthase n=2 Tax=Phytophthora ... 490 e-137 UniRef50_B4SI67 2-isopropylmalate synthase n=45 Tax=Xanthomonada... 487 e-136 UniRef50_D2RHN2 Isopropylmalate/citramalate/homocitratesynthase ... 487 e-136 UniRef50_C0Z635 Probable 2-isopropylmalate synthase n=1 Tax=Brev... 486 e-135 UniRef50_Q9LPR4 2-isopropylmalate synthase 1, chloroplastic n=39... 485 e-135 UniRef50_A2C859 2-isopropylmalate synthase n=16 Tax=Bacteria Rep... 484 e-135 UniRef50_UPI0001C31767 2-isopropylmalate synthase n=1 Tax=Conexi... 480 e-134 UniRef50_P58968 2-isopropylmalate synthase 2 n=19 Tax=Archaea Re... 474 e-132 UniRef50_O26819 (R)-citramalate synthase n=20 Tax=Archaea RepID=... 472 e-131 UniRef50_UPI0001C42034 citramalate synthase CimA n=1 Tax=Methano... 472 e-131 UniRef50_A9KRN2 2-isopropylmalate synthase n=8 Tax=Bacteria RepI... 470 e-131 UniRef50_UPI0001C41E20 2-isopropylmalate synthase LeuA n=1 Tax=M... 469 e-130 UniRef50_Q2S0M7 2-isopropylmalate synthase n=3 Tax=Bacteria RepI... 467 e-130 UniRef50_Q1ARE2 2-isopropylmalate synthase n=1 Tax=Rubrobacter x... 466 e-129 UniRef50_A6VFV4 Isopropylmalate/citramalate/homocitrate synthase... 466 e-129 UniRef50_C6CVJ5 2-isopropylmalate synthase n=2 Tax=Bacillales Re... 464 e-129 UniRef50_A8TGZ1 Isopropylmalate/citramalate/homocitrate synthase... 460 e-128 UniRef50_C5SF21 Pyruvate carboxyltransferase n=1 Tax=Asticcacaul... 447 e-124 UniRef50_Q0AT07 2-isopropylmalate synthase n=3 Tax=Alphaproteoba... 445 e-123 UniRef50_A8V4T9 2-isopropylmalate synthase (Fragment) n=2 Tax=ce... 443 e-123 UniRef50_D2RVT7 Pyruvate carboxyltransferase n=1 Tax=Haloterrige... 437 e-121 UniRef50_Q18KM5 2-isopropylmalate synthase n=9 Tax=Euryarchaeota... 430 e-119 UniRef50_O66682 Uncharacterized AIPM/Hcit synthase family transf... 429 e-118 UniRef50_Q2RGA1 2-isopropylmalate synthase n=5 Tax=Clostridia Re... 425 e-117 UniRef50_D2RHQ3 Isopropylmalate/citramalate/homocitratesynthase ... 422 e-116 UniRef50_Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic ... 407 e-112 UniRef50_C6PDK4 Pyruvate carboxyltransferase n=1 Tax=Thermoanaer... 406 e-111 UniRef50_A8AB61 2-isopropylmalate synthase n=25 Tax=Archaea RepI... 404 e-111 UniRef50_C3NF24 2-isopropylmalate synthase/homocitrate synthase ... 402 e-110 UniRef50_Q12166 2-isopropylmalate synthase 2, mitochondrial n=8 ... 389 e-106 UniRef50_P74269 Uncharacterized AIPM/Hcit synthase family transf... 388 e-106 UniRef50_Q57926 2-isopropylmalate synthase 1 n=16 Tax=Euryarchae... 388 e-106 UniRef50_P06208 2-isopropylmalate synthase n=109 Tax=cellular or... 387 e-106 UniRef50_A8L551 2-isopropylmalate synthase n=38 Tax=Bacteria Rep... 387 e-106 UniRef50_B9KY22 2-isopropylmalate synthase/homocitrate synthase ... 387 e-106 UniRef50_D1PA75 (R)-citramalate synthase n=1 Tax=Prevotella copr... 385 e-105 UniRef50_Q7VH30 2-isopropylmalate synthase n=16 Tax=Bacteria Rep... 384 e-105 UniRef50_Q02CM5 2-isopropylmalate synthase n=1 Tax=Candidatus So... 384 e-105 UniRef50_A4A2P3 2-isopropylmalate synthase n=1 Tax=Blastopirellu... 383 e-105 UniRef50_D2MJY3 2-isopropylmalate synthase n=1 Tax=Candidatus Po... 383 e-104 UniRef50_A8HXS9 Isopropylmalate synthase (Fragment) n=1 Tax=Chla... 382 e-104 UniRef50_A8ZTR1 2-isopropylmalate synthase/homocitrate synthase ... 382 e-104 UniRef50_B3TC58 Putative HMGL-like protein n=1 Tax=uncultured ma... 380 e-104 UniRef50_Q97MC5 2-isopropylmalate synthase n=50 Tax=Bacteria Rep... 378 e-103 UniRef50_Q3M862 2-isopropylmalate synthase n=4 Tax=Bacteria RepI... 378 e-103 UniRef50_C8WRC1 2-isopropylmalate synthase n=14 Tax=Bacteria Rep... 377 e-103 UniRef50_B3PEP5 2-isopropylmalate synthase n=90 Tax=Bacteria Rep... 376 e-102 UniRef50_C6VV54 Pyruvate carboxyltransferase n=32 Tax=Bacteria R... 373 e-102 UniRef50_A6C4F8 2-isopropylmalate synthase n=1 Tax=Planctomyces ... 373 e-101 UniRef50_D1AJT6 2-isopropylmalate synthase/homocitrate synthase ... 372 e-101 UniRef50_A1KBD3 2-isopropylmalate synthase n=14 Tax=Bacteria Rep... 371 e-101 UniRef50_B1MVR2 2-isopropylmalate synthase n=1 Tax=Leuconostoc c... 370 e-101 UniRef50_B1L4G2 Pyruvate carboxyltransferase n=1 Tax=Candidatus ... 370 e-100 UniRef50_C9RN88 2-isopropylmalate synthase/homocitrate synthase ... 367 e-100 UniRef50_Q04TA5 2-isopropylmalate/homocitrate synthase n=14 Tax=... 367 e-100 UniRef50_B2AHM5 2-isopropylmalate synthase n=69 Tax=cellular org... 366 1e-99 UniRef50_B2UP78 2-isopropylmalate synthase/homocitrate synthase ... 366 1e-99 UniRef50_D2QST1 Pyruvate carboxyltransferase n=1 Tax=Spirosoma l... 365 2e-99 UniRef50_UPI000038E0F9 2-isopropylmalate synthase n=1 Tax=Ferrop... 364 4e-99 UniRef50_Q0EZI5 2-isopropylmalate synthase n=1 Tax=Mariprofundus... 364 6e-99 UniRef50_Q6L0K4 2-isopropylmalate synthase n=1 Tax=Picrophilus t... 363 6e-99 UniRef50_B8FYI5 Pyruvate carboxyltransferase n=5 Tax=Bacteria Re... 362 1e-98 UniRef50_A5VPL4 2-isopropylmalate synthase/homocitrate synthase ... 362 2e-98 UniRef50_D1N7Y9 Pyruvate carboxyltransferase n=2 Tax=Victivallis... 362 3e-98 UniRef50_C1ZKW9 Isopropylmalate/homocitrate/citramalate synthase... 361 3e-98 UniRef50_A4QAP0 2-isopropylmalate synthase n=225 Tax=cellular or... 360 1e-97 UniRef50_P58967 2-isopropylmalate synthase 1 n=9 Tax=Euryarchaeo... 358 4e-97 UniRef50_B0CSN8 Predicted protein (Fragment) n=11 Tax=cellular o... 357 5e-97 UniRef50_A6LPH9 Homocitrate synthase n=10 Tax=Clostridia RepID=A... 356 1e-96 UniRef50_Q5KCL7 2-isopropylmalate synthase, putative n=1 Tax=Fil... 355 2e-96 UniRef50_Q2JTM1 Homocitrate synthase NifV n=7 Tax=Cyanobacteria ... 355 3e-96 UniRef50_B7GT76 2-isopropylmalate synthase n=19 Tax=Bifidobacter... 354 5e-96 UniRef50_Q3A2Q7 Homocitrate synthase 1 n=18 Tax=Bacteria RepID=Q... 353 8e-96 UniRef50_C9RKZ6 Pyruvate carboxyltransferase n=1 Tax=Fibrobacter... 353 1e-95 UniRef50_A6TTX4 Pyruvate carboxyltransferase n=1 Tax=Alkaliphilu... 353 1e-95 UniRef50_B3DXX9 Homocitrate/citramalate synthase n=1 Tax=Methyla... 349 1e-94 UniRef50_O86511 Uncharacterized AIPM/Hcit synthase family transf... 348 4e-94 UniRef50_Q44290 Homocitrate synthase 1 n=45 Tax=Bacteria RepID=N... 348 4e-94 UniRef50_D2RXB9 Pyruvate carboxyltransferase n=3 Tax=Halobacteri... 348 4e-94 UniRef50_A0LSS5 2-isopropylmalate synthase n=12 Tax=Bacteria Rep... 346 8e-94 UniRef50_B0TAQ1 Homocitrate synthase, nifv n=4 Tax=Clostridiales... 346 1e-93 UniRef50_D1XS06 2-isopropylmalate synthase n=1 Tax=Streptomyces ... 346 1e-93 UniRef50_C4XS62 Pyruvate carboxyltransferase n=1 Tax=Desulfovibr... 346 2e-93 UniRef50_D2L197 Pyruvate carboxyltransferase n=1 Tax=Desulfovibr... 345 4e-93 UniRef50_A6DIP7 2-isopropylmalate synthase n=1 Tax=Lentisphaera ... 343 7e-93 UniRef50_Q2FKU8 2-isopropylmalate synthase n=3 Tax=Methanomicrob... 343 1e-92 UniRef50_Q1QBL0 2-isopropylmalate synthase n=5 Tax=Bacteria RepI... 342 2e-92 UniRef50_C5S831 2-isopropylmalate synthase n=20 Tax=Bacteria Rep... 342 2e-92 UniRef50_C3MPM7 2-isopropylmalate synthase n=19 Tax=Thermoprotei... 341 5e-92 UniRef50_B8I2I3 Pyruvate carboxyltransferase n=1 Tax=Clostridium... 340 8e-92 UniRef50_Q8KTR5 Alpha-isopropylmalate synthase n=14 Tax=Candidat... 334 5e-90 UniRef50_B4S9H2 Pyruvate carboxyltransferase n=13 Tax=Bacteria R... 332 2e-89 UniRef50_A2QSZ0 Contig An09c0020, complete genome n=1 Tax=Asperg... 331 3e-89 UniRef50_B8FAB3 Pyruvate carboxyltransferase n=1 Tax=Desulfatiba... 331 4e-89 UniRef50_C1AUX2 2-isopropylmalate synthase n=8 Tax=Bacteria RepI... 330 6e-89 UniRef50_Q56216 2-isopropylmalate synthase (Fragment) n=1 Tax=Th... 330 8e-89 UniRef50_B9LUZ7 Pyruvate carboxyltransferase n=1 Tax=Halorubrum ... 330 8e-89 UniRef50_C8WE03 Homocitrate synthase n=3 Tax=Zymomonas mobilis R... 325 2e-87 UniRef50_C1SID8 Isopropylmalate/homocitrate/citramalate synthase... 325 2e-87 UniRef50_Q0ZQ46 FrbC n=3 Tax=Bacteria RepID=Q0ZQ46_9ACTO 324 5e-87 UniRef50_Q6KZ01 2-isopropylmalate synthase n=1 Tax=Picrophilus t... 323 8e-87 UniRef50_A6FCI3 2-isopropylmalate synthase n=1 Tax=Moritella sp.... 322 2e-86 UniRef50_C6HVD7 2-isopropylmalate synthase n=1 Tax=Leptospirillu... 322 2e-86 UniRef50_A9A1L0 Pyruvate carboxyltransferase n=6 Tax=Thaumarchae... 321 3e-86 UniRef50_P54610 Homocitrate synthase n=6 Tax=Frankia RepID=NIFV_... 320 8e-86 UniRef50_Q52070 Homocitrate synthase n=9 Tax=Gammaproteobacteria... 320 8e-86 UniRef50_Q9V1J1 2-isopropylmalate synthase 2 n=5 Tax=Thermococca... 318 3e-85 UniRef50_A7IBL6 Homocitrate synthase n=19 Tax=Proteobacteria Rep... 318 4e-85 UniRef50_B6YRB4 Homocitrate synthase n=1 Tax=Candidatus Azobacte... 317 6e-85 UniRef50_C1FHL1 2-isopropylmalate synthase n=2 Tax=cellular orga... 317 6e-85 UniRef50_UPI000038E0D5 2-isopropylmalate synthase n=1 Tax=Ferrop... 315 2e-84 UniRef50_Q12122 Homocitrate synthase, mitochondrial n=109 Tax=ce... 315 2e-84 UniRef50_C0W2B6 Alpha-isopropylmalate/homocitrate synthase famil... 314 7e-84 UniRef50_Q7M8U7 HOMOCITRATE SYTHASE 1 n=1 Tax=Wolinella succinog... 313 9e-84 UniRef50_B0TW82 2-isopropylmalate synthase n=17 Tax=Francisella ... 312 2e-83 UniRef50_C5QA64 2-isopropylmalate synthase n=1 Tax=Staphylococcu... 309 2e-82 UniRef50_B5JMT2 HMGL-like domain protein n=1 Tax=Verrucomicrobia... 306 9e-82 UniRef50_Q2GMU3 Putative uncharacterized protein n=1 Tax=Chaetom... 304 4e-81 UniRef50_A9VAW1 Predicted protein n=1 Tax=Monosiga brevicollis R... 304 7e-81 UniRef50_D2LHQ1 Homocitrate synthase n=1 Tax=Rhodomicrobium vann... 302 2e-80 UniRef50_A8F3U8 2-isopropylmalate synthase n=1 Tax=Thermotoga le... 301 6e-80 UniRef50_B7G5N8 2-isopropylmalate synthase n=2 Tax=Bacillariophy... 299 2e-79 UniRef50_D0LNR8 Pyruvate carboxyltransferase n=1 Tax=Haliangium ... 296 1e-78 UniRef50_Q01181 Homocitrate synthase n=27 Tax=Proteobacteria Rep... 296 1e-78 UniRef50_Q07179 Homocitrate synthase n=3 Tax=Rhodobacter RepID=N... 294 5e-78 UniRef50_Q04QM8 Isopropylmalate/homocitrate/citramalatesynthase ... 293 1e-77 UniRef50_C9K7B8 Similar to 2-isopropylmalate synthase n=1 Tax=Al... 293 1e-77 UniRef50_B8FRV4 2-isopropylmalate synthase n=2 Tax=Desulfitobact... 291 4e-77 UniRef50_A3JSY7 Putative uncharacterized protein n=2 Tax=Bacteri... 289 1e-76 UniRef50_C7N750 Isopropylmalate/homocitrate/citramalate synthase... 289 2e-76 UniRef50_Q0W3Q1 2-isopropylmalate synthase n=8 Tax=Archaea RepID... 284 4e-75 UniRef50_C6BX35 Pyruvate carboxyltransferase n=1 Tax=Desulfovibr... 282 2e-74 UniRef50_D1U2X4 Pyruvate carboxyltransferase n=1 Tax=Desulfovibr... 282 3e-74 UniRef50_B5HTY3 2-isopropylmalate synthase n=1 Tax=Streptomyces ... 279 2e-73 UniRef50_Q1IYY1 Homocitrate synthase n=1 Tax=Deinococcus geother... 278 3e-73 UniRef50_B0PEC7 Putative uncharacterized protein n=1 Tax=Anaerot... 276 1e-72 UniRef50_C0AC93 Trans-homoaconitate synthase n=2 Tax=Opitutaceae... 276 2e-72 UniRef50_C7LNR6 Pyruvate carboxyltransferase n=1 Tax=Desulfomicr... 274 6e-72 UniRef50_Q2FZS6 2-isopropylmalate synthase, putative n=51 Tax=St... 271 4e-71 UniRef50_B9YLN5 2-isopropylmalate synthase n=2 Tax=Nostocaceae R... 269 1e-70 UniRef50_C6A4Y6 2-isopropylmalate synthase 1 n=1 Tax=Thermococcu... 265 3e-69 UniRef50_Q10Y65 2-isopropylmalate synthase n=1 Tax=Trichodesmium... 264 5e-69 UniRef50_C0GSN3 Pyruvate carboxyltransferase n=1 Tax=Desulfonatr... 264 7e-69 UniRef50_C8W3E1 Pyruvate carboxyltransferase n=1 Tax=Desulfotoma... 259 2e-67 UniRef50_C1XGU5 Isopropylmalate/homocitrate/citramalate synthase... 258 3e-67 UniRef50_D2JWV4 Putative homocitrate synthase n=1 Tax=Filobasidi... 257 6e-67 UniRef50_A4QUQ8 Putative uncharacterized protein n=1 Tax=Magnapo... 257 6e-67 UniRef50_P70728 Homocitrate synthase n=1 Tax=Azospirillum brasil... 257 8e-67 UniRef50_C0Z7H0 Alpha-isopropylmalate/homocitrate synthase famil... 256 2e-66 UniRef50_A8A943 Pyruvate carboxyltransferase n=1 Tax=Ignicoccus ... 254 4e-66 UniRef50_Q46A98 Homocitrate synthase n=2 Tax=Methanosarcina RepI... 253 1e-65 UniRef50_A6FZR1 Homocitrate synthase n=1 Tax=Plesiocystis pacifi... 253 1e-65 UniRef50_B8DR73 Pyruvate carboxyltransferase n=3 Tax=Desulfovibr... 252 2e-65 UniRef50_B1L5J0 2-isopropylmalate synthase n=1 Tax=Candidatus Ko... 251 7e-65 UniRef50_D1J0N9 Whole genome shotgun sequence of line PN40024, s... 250 9e-65 UniRef50_Q3IV11 Isopropylmalate/homocitrate synthase n=1 Tax=Rho... 250 1e-64 UniRef50_B2KBD6 Pyruvate carboxyltransferase n=7 Tax=Bacteria Re... 249 2e-64 UniRef50_Q7X1M2 Homocitrate synthase (Fragment) n=1 Tax=Leptospi... 249 3e-64 UniRef50_C9YAE2 Putative uncharacterized protein n=1 Tax=Curviba... 248 4e-64 UniRef50_A8TLL5 Homocitrate synthase n=1 Tax=alpha proteobacteri... 248 4e-64 UniRef50_C5AK37 Isopropylmalate/homocitrate/citramalate synthase... 247 8e-64 UniRef50_A9HXK1 2-isopropylmalate synthase (Fragment) n=1 Tax=Ro... 246 2e-63 UniRef50_B8J227 Pyruvate carboxyltransferase n=2 Tax=Desulfovibr... 241 5e-62 UniRef50_C7GH85 2-isopropylmalate synthase n=3 Tax=Roseburia Rep... 239 2e-61 UniRef50_A5N6T4 2-isopropylmalate synthase-related protein n=2 T... 237 6e-61 UniRef50_Q2LTE1 Isopropylmalate/homocitrate/citramalate synthase... 237 7e-61 UniRef50_B1I1Z4 Pyruvate carboxyltransferase n=1 Tax=Candidatus ... 236 2e-60 UniRef50_Q1NS12 Pyruvate carboxyltransferase n=2 Tax=delta prote... 236 2e-60 UniRef50_B4WHZ2 HMGL-like domain protein n=1 Tax=Synechococcus s... 235 3e-60 UniRef50_Q1DCT2 2-isopropylmalate synthase/homocitrate synthase ... 234 8e-60 UniRef50_C7IGD9 Homocitrate synthase n=1 Tax=Clostridium papyros... 230 1e-58 UniRef50_C1MYB9 2-isopropylmalate synthase n=1 Tax=Micromonas pu... 230 1e-58 UniRef50_Q72WS3 Homocitrate synthase n=2 Tax=Desulfovibrio vulga... 229 2e-58 UniRef50_B4B8D2 Pyruvate carboxyltransferase n=1 Tax=Cyanothece ... 227 6e-58 UniRef50_A8MBK1 Pyruvate carboxyltransferase n=1 Tax=Caldivirga ... 226 2e-57 UniRef50_P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial n... 225 4e-57 UniRef50_UPI0001B425AC 2-isopropylmalate synthase n=1 Tax=Lister... 225 4e-57 UniRef50_B1QUV5 Homocitrate synthase 1 n=2 Tax=Clostridium butyr... 222 2e-56 UniRef50_B2J8P8 Pyruvate carboxyltransferase n=2 Tax=Nostocaceae... 222 2e-56 UniRef50_D0LGL9 2-isopropylmalate synthase n=3 Tax=Nannocystinea... 222 4e-56 UniRef50_Q2RAU5 Hydroxymethylglutaryl-CoA lyase, mitochondrial, ... 221 6e-56 UniRef50_A6CMV0 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillus... 220 1e-55 UniRef50_A0YSY8 2-isopropylmalate synthase n=1 Tax=Lyngbya sp. P... 219 2e-55 UniRef50_C7YY11 Putative uncharacterized protein n=2 Tax=Nectria... 219 2e-55 UniRef50_B0SA13 2-isopropylmalate synthase n=5 Tax=Leptospira Re... 218 4e-55 UniRef50_A8WG57 Probable 3-hydroxymethyl-3-methylglutaryl-CoA ly... 217 7e-55 UniRef50_Q8TB92 Probable 3-hydroxymethyl-3-methylglutaryl-CoA ly... 217 1e-54 UniRef50_C0GGI7 Pyruvate carboxyltransferase n=1 Tax=Dethiobacte... 216 2e-54 UniRef50_P35915 Hydroxymethylglutaryl-CoA lyase n=108 Tax=cellul... 215 3e-54 UniRef50_O34873 Hydroxymethylglutaryl-CoA lyase yngG n=13 Tax=Ba... 214 5e-54 UniRef50_Q97A78 2-isopropylmalate/homocitrate synthetase n=1 Tax... 214 7e-54 UniRef50_C5T2M7 Pyruvate carboxyltransferase n=1 Tax=Acidovorax ... 214 1e-53 UniRef50_UPI00015B4E2A PREDICTED: similar to hydroxymethylglutar... 213 1e-53 UniRef50_C8QZK2 2-isopropylmalate synthase n=1 Tax=Desulfurivibr... 213 1e-53 UniRef50_D2VQL9 Predicted protein n=1 Tax=Naegleria gruberi RepI... 212 2e-53 UniRef50_C0WB33 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria... 212 3e-53 UniRef50_Q00853 Homocitrate synthase subunit alpha n=8 Tax=Clost... 212 4e-53 UniRef50_A8MB07 2-isopropylmalate synthase n=1 Tax=Caldivirga ma... 211 5e-53 UniRef50_O81027 Hydroxymethylglutaryl-CoA lyase, mitochondrial n... 211 7e-53 UniRef50_D0MGG7 Pyruvate carboxyltransferase n=1 Tax=Rhodothermu... 211 8e-53 UniRef50_Q28KR2 Hydroxymethylglutaryl-CoA lyase n=5 Tax=Alphapro... 209 3e-52 UniRef50_Q15RQ1 Hydroxymethylglutaryl-CoA lyase n=89 Tax=Bacteri... 209 3e-52 UniRef50_C8WQC0 Pyruvate carboxyltransferase n=2 Tax=Alicyclobac... 208 4e-52 UniRef50_D0Z8X0 Putative hydroxymethylglutaryl-CoA lyase n=1 Tax... 207 1e-51 UniRef50_A9F2G5 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacteria... 206 1e-51 UniRef50_Q6MHG9 Hydroxymethylglutaryl-CoA lyase n=1 Tax=Bdellovi... 205 5e-51 UniRef50_A4X0W1 Pyruvate carboxyltransferase n=3 Tax=Actinomycet... 204 7e-51 UniRef50_C6JJQ3 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria... 202 2e-50 UniRef50_A8FDY7 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacillus... 202 2e-50 UniRef50_C7MUV0 Hydroxymethylglutaryl-CoA lyase n=5 Tax=cellular... 202 3e-50 UniRef50_A4VK95 Hydroxymethylglutaryl-CoA lyase n=63 Tax=cellula... 201 4e-50 UniRef50_C6PWR8 Pyruvate carboxyltransferase n=1 Tax=Clostridium... 201 5e-50 UniRef50_B4BIN3 Pyruvate carboxyltransferase n=1 Tax=Geobacillus... 201 6e-50 UniRef50_Q2C751 Putative hydroxymethylglutaryl-CoA lyase n=3 Tax... 200 8e-50 UniRef50_C1D9E0 Hydroxymethylglutaryl-CoA lyase n=9 Tax=cellular... 200 9e-50 UniRef50_A8MEN7 Pyruvate carboxyltransferase n=1 Tax=Alkaliphilu... 199 3e-49 UniRef50_B6QTB6 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyas... 199 3e-49 UniRef50_D1TMW3 Hydroxymethylglutaryl-CoA lyase n=1 Tax=Burkhold... 198 4e-49 UniRef50_B4VB43 2-isopropylmalate synthase n=1 Tax=Streptomyces ... 198 4e-49 UniRef50_Q146L0 Hydroxymethylglutaryl-CoA lyase n=18 Tax=cellula... 198 4e-49 UniRef50_Q5WKL8 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillac... 198 4e-49 UniRef50_A3JC95 Pyruvate carboxyltransferase n=5 Tax=Gammaproteo... 198 5e-49 UniRef50_B4RE97 3-hydroxy-3-methylglutarate-CoA lyase n=4 Tax=Ba... 198 5e-49 Sequences not found previously or not previously below threshold: >UniRef50_B2VDA7 2-isopropylmalate synthase n=4 Tax=Enterobacteriaceae RepID=LEU1_ERWT9 Length = 522 Score = 578 bits (1489), Expect = e-163, Method: Composition-based stats. Identities = 431/523 (82%), Positives = 477/523 (91%), Gaps = 1/523 (0%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT Sbjct: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 IARQ+KNSRVC LARCVEKDID A E+L+VA+A+RIHTF+ATSPMHIATKLRSTL EVIE Sbjct: 61 IARQIKNSRVCGLARCVEKDIDAAYEALRVADAYRIHTFLATSPMHIATKLRSTLPEVIE 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 RA+ M++RARNYTDDVEFSCED GRTPI DL RVVEAAINAGATTINIPDTVGYT+P+E+ Sbjct: 121 RAVKMIRRARNYTDDVEFSCEDGGRTPIDDLCRVVEAAINAGATTINIPDTVGYTLPYEY 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 A I S L RVPNIDKAI+SVHTHDDLG+AVGN+LAAV+AGARQ+EGAMNG+GERAGNC+ Sbjct: 181 ANIFSALRARVPNIDKAILSVHTHDDLGMAVGNALAAVNAGARQIEGAMNGLGERAGNCA 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEE IMAIK R ++NVHT INHQEI+RT Q VS+ICNMPIPA+KAI+GS AFAHSSGIH Sbjct: 241 LEETIMAIKTRGQLMNVHTRINHQEIYRTCQTVSKICNMPIPAHKAIIGSNAFAHSSGIH 300 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 QDGVLKNRENYEI+TPESIGL Q+QLNLTSRSGRAAVKHRM+EMGY E+EYN+D LYDAF Sbjct: 301 QDGVLKNRENYEILTPESIGLKQVQLNLTSRSGRAAVKHRMEEMGYGETEYNMDRLYDAF 360 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 LADKKGQVFDYDLEALAFI +Q EEPE+FRLD F+VQSGS+ IATA V+L CG+E K Sbjct: 361 KALADKKGQVFDYDLEALAFINQQSEEPEYFRLDTFNVQSGSSVIATATVQLRCGDEQKT 420 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 EAA GNGPVDAVYQAINR+TE++ ELV Y LTAKGHGKDALGQVDIV YNGR+FHGVGL Sbjct: 421 EAATGNGPVDAVYQAINRLTEFDAELVSYQLTAKGHGKDALGQVDIVVQYNGRKFHGVGL 480 Query: 481 ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV 523 ATDIVESSAKAMV+ LN IWRA +VE+ELQRK+Q ++ KETV Sbjct: 481 ATDIVESSAKAMVNALNTIWRARQVEQELQRKSQ-VKDQKETV 522 >UniRef50_A6T4L9 2-isopropylmalate synthase n=327 Tax=Bacteria RepID=LEU1_KLEP7 Length = 523 Score = 575 bits (1481), Expect = e-162, Method: Composition-based stats. Identities = 486/523 (92%), Positives = 512/523 (97%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT Sbjct: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 IAR +KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE Sbjct: 61 IARTIKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE+ Sbjct: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEY 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 A IISGLY+RVPNIDKAIISVHTHDDLG+AVGN+LAAVHAGARQVEGAMNGIGERAGNC+ Sbjct: 181 ANIISGLYDRVPNIDKAIISVHTHDDLGIAVGNALAAVHAGARQVEGAMNGIGERAGNCA 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEVIMAIKVRKDI+NVHT INH EIWRTSQ VSQICNMPIPANKAIVG+GAFAHSSGIH Sbjct: 241 LEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGTGAFAHSSGIH 300 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 QDGVLKNRENYEIMTPESIGLNQ+QLNLTSRSGRAAVKHRM+EMGY+ES+YNLD+LYDAF Sbjct: 301 QDGVLKNRENYEIMTPESIGLNQVQLNLTSRSGRAAVKHRMEEMGYQESDYNLDHLYDAF 360 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 LKLADKKGQVFDYDLEALAFI KQQEEPEHFRLDYF+VQSGS+DIATA++KL CG+E+K Sbjct: 361 LKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFNVQSGSSDIATASIKLVCGDEIKT 420 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 EAANGNGPVDA+YQAINR+T+YN+ELVKY L+AKGHGKDALGQVDIV +YNGRRFHGVGL Sbjct: 421 EAANGNGPVDAIYQAINRVTDYNIELVKYGLSAKGHGKDALGQVDIVVDYNGRRFHGVGL 480 Query: 481 ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV 523 ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQ+ ENNKETV Sbjct: 481 ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV 523 >UniRef50_Q3AEQ5 2-isopropylmalate synthase n=42 Tax=Bacteria RepID=LEU1_CARHZ Length = 509 Score = 556 bits (1432), Expect = e-157, Method: Composition-based stats. Identities = 267/509 (52%), Positives = 354/509 (69%), Gaps = 2/509 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 ++V IFDTTLRDGEQ+ SL+ EKLQIA L+++GVDV+E GFP++SPGD E+V IA Sbjct: 2 ERVRIFDTTLRDGEQSPGVSLNAMEKLQIARQLQKLGVDVIEAGFPITSPGDKEAVSLIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 R+VK V ALAR DI+ A +++K AE+ RIHTFIATS +H+ KL+ + V+ERA Sbjct: 62 REVKGVVVAALARASALDIETAWDAIKDAESPRIHTFIATSDIHLKYKLKMDRETVVERA 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + VK A+ +T DVEFS EDA R+ + L RVVEAA+ AGATTINIPDTVGY P EF Sbjct: 122 VAAVKLAKKFTADVEFSAEDASRSDLDFLCRVVEAAVKAGATTINIPDTVGYAEPEEFGE 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I + E+VP +D+A++SVH HDDLGLAV NSLAA+ GARQVE +NGIGERAGNCSLE Sbjct: 182 FICKILEKVPVMDRAVLSVHCHDDLGLAVANSLAAIKNGARQVECTINGIGERAGNCSLE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E++MA+ RKD+L +T I +EI+RTS+LVS + MP+ NKAIVG AF+H SGIHQD Sbjct: 242 EIVMALYTRKDVLPFYTGIKTEEIYRTSKLVSNLTGMPVQPNKAIVGKNAFSHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 GVLK R YEIM P +G+ + +L L SGR A+K R+ E+GY+ +E L+ + F Sbjct: 302 GVLKERTTYEIMNPRLVGIPESRLVLGKHSGRHALKERLLELGYELTEEQLNEAFVKFKA 361 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEA 422 LADKK +V D DLEA+ + ++ PE + LDYF + +GS I TA V L E +A Sbjct: 362 LADKKKEVTDQDLEAMM-EEEIRKVPETYTLDYFHISTGSTIIPTATVGLIKEGEKLEDA 420 Query: 423 ANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYN-GRRFHGVGLA 481 A G+GPVDA+Y+AIN+IT L +YS+ A G+DALG+V + G+ G G++ Sbjct: 421 ATGDGPVDAIYKAINKITGLTPVLEQYSINAVTSGEDALGEVVVKLKNGLGKIVTGRGVS 480 Query: 482 TDIVESSAKAMVHVLNNIWRAAEVEKELQ 510 TDI+E+SAKA ++ +N + + + E Q Sbjct: 481 TDILEASAKAYLNGINKLLFDYQAKGEKQ 509 >UniRef50_B8DM91 2-isopropylmalate synthase n=31 Tax=Bacteria RepID=LEU1_DESVM Length = 514 Score = 538 bits (1386), Expect = e-151, Method: Composition-based stats. Identities = 252/499 (50%), Positives = 331/499 (66%), Gaps = 2/499 (0%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 S ++ IFDTTLRDGEQ+ A+++++EK+++A LE +GVD+ME GFP SS GDFE+VQ I Sbjct: 5 SGRIRIFDTTLRDGEQSPGATMNLQEKIRLARQLETLGVDIMEAGFPASSQGDFEAVQAI 64 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 AR VK V L R + DID A E++KVAE RIHTF+ATSP+H+ KLR D+V+E Sbjct: 65 ARAVKGVEVAGLCRAMPADIDRAWEAVKVAENPRIHTFLATSPVHMQYKLRKEPDQVVEM 124 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 A+ V+ A YT +VEFS EDA R+ L RV EA INAGATTIN+PDTVGY P EF Sbjct: 125 AVAAVRHAAKYTSNVEFSAEDASRSNPDFLVRVFEAVINAGATTINVPDTVGYAQPEEFG 184 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 +I + E PN KA+ SVH H+DLG+ V N+LAA+ AGARQ E ++GIGERAGN SL Sbjct: 185 RLIRYVIENTPNSHKAVFSVHCHNDLGMGVANTLAALKAGARQAEVTISGIGERAGNASL 244 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EE++MA+ R+D + + ++++ T +L+S I PIP NKAIVG+ AFAH SGIHQ Sbjct: 245 EEIVMALHTRRDFYQLDCGVVTEQLFPTCRLLSMIIGQPIPPNKAIVGANAFAHESGIHQ 304 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 DG+LKNRE YEIMTPESIG + L + SGR AVK+++DE+GY+ E L +++A Sbjct: 305 DGMLKNRETYEIMTPESIGKTKTDLVIGKHSGRNAVKNKLDELGYRLEEAQLVTVFEAVK 364 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQS-GSNDIATAAVKLACGEEVKA 420 KLADKK Q++D D+EAL + P+ +RL SVQ + TAAV + EVK Sbjct: 365 KLADKKKQIYDEDIEALVLEEVYRL-PDLYRLVNLSVQCSDTGMPPTAAVVMDVMGEVKR 423 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 A G GP+DAV+ I I L +YS+TA G DA G+V + NG G G Sbjct: 424 AAGFGVGPIDAVFNVIGEIVGRAPVLERYSVTAITGGTDAQGEVTVRLRQNGSSAVGRGS 483 Query: 481 ATDIVESSAKAMVHVLNNI 499 DI+ +SA+A V+ LN + Sbjct: 484 DPDIILASARAYVNALNRL 502 >UniRef50_B7GH19 2-isopropylmalate synthase n=98 Tax=cellular organisms RepID=LEU1_ANOFW Length = 514 Score = 537 bits (1383), Expect = e-151, Method: Composition-based stats. Identities = 240/513 (46%), Positives = 333/513 (64%), Gaps = 1/513 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ IFDTTLRDGEQ+ +L++ EKL+IA LER+GVD++E GFP +S GDF++VQ IA Sbjct: 2 RKINIFDTTLRDGEQSAGVNLNLHEKLEIARQLERLGVDIIEAGFPAASKGDFQAVQAIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 + V+N V L+R V+ DID A E+LK R+H FIATSP+H+ KLR T ++V+E A Sbjct: 62 QTVRNCSVTGLSRSVQSDIDAAWEALKDGAEPRLHVFIATSPIHMQYKLRMTPEQVVETA 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + V+ A+ Y V++S EDA R+ + LA +VE I AGA INIPDTVGY P ++ Sbjct: 122 VESVRYAKKYFPIVQWSAEDACRSDLPFLATIVEKVIEAGANVINIPDTVGYITPKQYGD 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I S L + V NI+K +S H HDDLG+AV NSLAA+ AGA Q+EG +NGIGERAGN ++E Sbjct: 182 IFSFLKKNVRNIEKISLSAHCHDDLGMAVANSLAAIEAGATQIEGTINGIGERAGNAAIE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV +A+ +RKD T +N QEI RTS LVS++ M +PANKAIVG AFAH SGIHQD Sbjct: 242 EVAVALYIRKDYYQAETRLNLQEIKRTSSLVSKLTGMIVPANKAIVGKNAFAHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 GVLK + YEI++P+ +G+ + L SGR A + R+ E+GY +E ++ L+ F Sbjct: 302 GVLKEKTTYEIISPQLVGVQSNSMVLGKHSGRHAFRTRIQELGYSLTEEEVNRLFVRFKD 361 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACG-EEVKAE 421 LADKK + D DL AL K ++L VQ G+N I TA V L G E Sbjct: 362 LADKKKDITDDDLIALILDEKLDTYKNFYQLCSIQVQYGTNQIPTAVVVLKDGEGNDIQE 421 Query: 422 AANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLA 481 AA G G V+A+Y A+ + + V L+ Y + + G G+DAL QV + + + + G G A Sbjct: 422 AATGAGSVEALYNALEKALQLPVTLLDYRIESVGSGRDALAQVYVKVSLDRKEASGRGTA 481 Query: 482 TDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQ 514 D++E+SAKA +H +N ++ ++++E AQ Sbjct: 482 QDVLEASAKAYIHAVNRMFVIEKMKEEQALAAQ 514 >UniRef50_B8J4F8 2-isopropylmalate synthase n=3 Tax=Desulfovibrionales RepID=B8J4F8_DESDA Length = 515 Score = 536 bits (1380), Expect = e-150, Method: Composition-based stats. Identities = 245/518 (47%), Positives = 329/518 (63%), Gaps = 5/518 (0%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+ +V FDTTLRDGEQ+ A+++++EKL++A LE +GVD+ME GFP SSPGDFESVQ Sbjct: 1 MNNRVYFFDTTLRDGEQSPGATMNLQEKLRLAHQLEVLGVDIMEAGFPASSPGDFESVQR 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 IA Q + +V LARCV DID E++K A RIH F++TSP+H+ KLR D+V+ Sbjct: 61 IAAQAGDIQVAGLARCVAGDIDRCWEAIKNARNPRIHIFLSTSPLHMRHKLRKDPDDVLR 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 A+ VKR YTD+VEFSCED R+ L RVVEA I AGATT+N+PDTVGY P E+ Sbjct: 121 MAVEGVKRCAMYTDNVEFSCEDFSRSEPEFLCRVVEAVIKAGATTVNLPDTVGYAQPAEY 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 A I + PN DKA+ SVH H+DLGLAV N+LAA G RQ E +NGIGERAGN S Sbjct: 181 AARIEHVISNTPNSDKAVFSVHCHNDLGLAVANTLAAFRVGVRQAEVTLNGIGERAGNAS 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV+M ++VR+D + I ++++ + +L+S PIP NKAIVG+ AFAH SGIH Sbjct: 241 LEEVVMNLRVRQDYFGLEHNIVTEQLYPSCRLLSMTIGQPIPNNKAIVGANAFAHESGIH 300 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 QDG+LKNRE YEIMTP+S+G + L + SGR AV+++ + MGYK + L+ +++A Sbjct: 301 QDGMLKNRETYEIMTPQSVGRTESNLVIGKHSGRNAVRNKFEAMGYKLDDDQLNLIFEAV 360 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSG--SNDIATAAVKLACGEEV 418 +LAD+K + D DL AL + P+ FRL + SVQS TAAV + + Sbjct: 361 KQLADRKKNLHDDDLMALVQEEIYRA-PDRFRLRHVSVQSSDTGGVPPTAAVIMDVDGKE 419 Query: 419 KAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGV 478 + A G GPVDA++ I + EL +Y++ A G DALG+V + G Sbjct: 420 SSGAGFGVGPVDALFNVIADMVGREAELEQYAINAITGGTDALGEVTVRLRDGEYSAVGR 479 Query: 479 GLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHN 516 G DI +SA+A V+ LN++ + E L QH+ Sbjct: 480 GTHPDIFVASARAYVNALNHLAKKEEEGPRLH--CQHD 515 >UniRef50_Q7UI51 2-isopropylmalate synthase n=1 Tax=Rhodopirellula baltica RepID=LEU1_RHOBA Length = 527 Score = 535 bits (1379), Expect = e-150, Method: Composition-based stats. Identities = 243/501 (48%), Positives = 334/501 (66%), Gaps = 1/501 (0%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 ++Q+ IFDTTLRDGEQ+ AS+++ EKL++A AL +GVD++E GFP++SPGDFESV+ I Sbjct: 15 TRQIRIFDTTLRDGEQSPGASMNLAEKLEVASALVDLGVDIIEAGFPIASPGDFESVRQI 74 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 A ++ + +C LARC EKDID A E+LK A RIH F+ATS +H KLR T DE++ER Sbjct: 75 ATTIRGATICGLARCAEKDIDRAWEALKTAPQARIHVFLATSAIHREFKLRMTPDEIVER 134 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 A+ V+RA ++ DDVEFS EDA RT L RVVEAAI+AGATTIN+PDTVGYT P E Sbjct: 135 AVAGVRRAASHCDDVEFSPEDACRTEHDFLCRVVEAAIDAGATTINVPDTVGYTTPGEIY 194 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 L +RVPN+DKA++S H HDDLG+AV NSLAAV AGA Q+E +NGIGERAGN +L Sbjct: 195 DRFKMLRDRVPNMDKAVLSTHCHDDLGMAVANSLAAVDAGAGQIECTINGIGERAGNAAL 254 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EE++MA+K R+D + T IN + + S+LVS+ + + NKAIVG AFAH SGIHQ Sbjct: 255 EELVMAMKTRQDFYHCQTNINSKRLVPVSRLVSKTTGINVQRNKAIVGRNAFAHESGIHQ 314 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 DG+LK R YEIM+PE +G + L L SGRAA+ R ++G + L +++AF Sbjct: 315 DGMLKERTTYEIMSPEEVGFTKTDLVLGKHSGRAALADRAKQLGMTLTGEQLQEVFEAFK 374 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAE 421 +LADKK +++D D+ AL + + L + V SG N V L E+ E Sbjct: 375 ELADKKKEIYDGDIVALVQQKISETVAPEWTLVDYEVTSGKNQTPNVRVTLRRDEQDITE 434 Query: 422 A-ANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 A G+GP+DA + A+ +IT V + + + G+DA+G+V++ + G+ + G G+ Sbjct: 435 QVAQGDGPIDAAFWAVEKITGIQVVCKDFRVRSATLGRDAIGEVNLEVEHEGKTYRGTGV 494 Query: 481 ATDIVESSAKAMVHVLNNIWR 501 +TD VES+ AM++ +N I Sbjct: 495 STDSVESTILAMLNAINRIVA 515 >UniRef50_A4YZ76 2-isopropylmalate synthase n=131 Tax=root RepID=LEU1_BRASO Length = 525 Score = 533 bits (1373), Expect = e-150, Method: Composition-based stats. Identities = 232/502 (46%), Positives = 322/502 (64%), Gaps = 1/502 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +V+IFDTTLRDGEQ A+++ +EKL IA L+ MGVD++E GFP++S GDFE+V IA Sbjct: 10 DRVVIFDTTLRDGEQCPGATMTFEEKLNIAAMLDDMGVDIIEAGFPIASDGDFEAVNEIA 69 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 ++ KN+ +C L+R KDID AE+++ A+ RIHTF++TSP+H+ KL+ +V E Sbjct: 70 KRSKNAVICGLSRAGAKDIDRCAEAIRPAKRGRIHTFLSTSPVHMKYKLQMDPQQVFELV 129 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 I V RARN+TDDVE+S ED RT L R VEAAI AGA+TINIPDTVGY +P E+ Sbjct: 130 ISSVTRARNHTDDVEWSSEDGTRTEFDFLCRCVEAAIKAGASTINIPDTVGYAVPEEYYD 189 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + + E VPN DKA+ SVH H+DLG+AV NS+A V AGARQ+E +NGIGERAGN +LE Sbjct: 190 LFKRVRETVPNSDKAVFSVHCHNDLGMAVANSMAGVRAGARQIECTINGIGERAGNAALE 249 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV+MA++VR D L I+ ++ S++VS + P+ NKAIVG AFAH SGIHQD Sbjct: 250 EVVMAMRVRNDKLPFWNKIDTTQLTHASKVVSAATSFPVQYNKAIVGRNAFAHESGIHQD 309 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G+LKN + YEIM PE++G+ Q L + SGR A H+++EMG+K S +++ + F Sbjct: 310 GMLKNAQTYEIMLPETVGVKQTSLVMGKHSGRHAFIHKLEEMGHKLSSNQVEDAFVRFKA 369 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEA 422 LAD+K Q++D D+EAL G + +L SV +G+ A +KL + E Sbjct: 370 LADRKKQIYDEDIEALIDEGMVSA-HDRIKLLSLSVIAGTRGPQRATMKLDIDGVTRIEE 428 Query: 423 ANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLAT 482 + GNGPVDAV+ I + + +L Y + A G DA +V + + +GR Sbjct: 429 SEGNGPVDAVFNCIKSLVPHEAKLELYQVHAVTEGTDAQAEVSVRLSQDGRSMTARAADP 488 Query: 483 DIVESSAKAMVHVLNNIWRAAE 504 D + +SAKA + LN + + Sbjct: 489 DTLVASAKAYLGALNKLVMKRQ 510 >UniRef50_A7Z7B8 2-isopropylmalate synthase n=11 Tax=Bacillales RepID=LEU1_BACA2 Length = 518 Score = 531 bits (1367), Expect = e-149, Method: Composition-based stats. Identities = 227/498 (45%), Positives = 318/498 (63%), Gaps = 2/498 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ +FDTTLRDGEQ+ +L+ +EKL IA LER+GVD++E GFP SS GDF +VQ IA Sbjct: 2 RKINVFDTTLRDGEQSPGVNLNSREKLAIAKQLERLGVDIIEAGFPASSRGDFLAVQEIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 R +KN V LAR V+ DID A E+LK + RIH FIATS +H+ KL+ T +EV E+A Sbjct: 62 RTIKNCSVTGLARSVKGDIDAAWEALKDGVSPRIHIFIATSDIHLKHKLKMTREEVKEKA 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + MVK A+ V++S EDA RT + LA +VE I+AGA+ IN+PDTVGY P E+ Sbjct: 122 VEMVKYAKERFPIVQWSAEDACRTELPFLAEIVEEVIDAGASVINLPDTVGYLTPDEYGN 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I + E VPNI + +S H HDDLG+AV NSL+A+ GA Q+E A+NGIGERAGN +LE Sbjct: 182 IFKYMKEHVPNISRVKLSAHCHDDLGMAVANSLSAIENGADQIECAINGIGERAGNAALE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E+ +A+ VR D +++N E+ RTS LVS++ M +P NKAIVG AFAH SGIHQD Sbjct: 242 EIAVALHVRNDAHQADSSLNLHELKRTSDLVSKLTGMAVPRNKAIVGDNAFAHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G LK + YEI++PE +G+ L L SGR A K R++ +G++ ++ + F + Sbjct: 302 GFLKEKSTYEIISPELVGVTADALVLGKHSGRHAFKDRLNTLGFQFDSDEINKYFTMFKE 361 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA-- 420 L +KK ++ D DL +L K ++ + V G++ + TA V L E + Sbjct: 362 LTEKKKEITDDDLISLILEEKVTDKKIGYEFLSLQVHYGTSQVPTATVSLKNQENEQLMQ 421 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 EAA G G V+AVY + R + N+EL Y + + G+DAL QV + NG+ G G+ Sbjct: 422 EAATGAGSVEAVYNTLGRCIDKNIELTDYRIQSNRKGEDALAQVFVRVTVNGKESSGRGI 481 Query: 481 ATDIVESSAKAMVHVLNN 498 A D++E+SAKA ++ +N Sbjct: 482 AQDVLEASAKAYLNAVNR 499 >UniRef50_Q2YBW0 2-isopropylmalate synthase n=2 Tax=Bacteria RepID=LEU1_NITMU Length = 510 Score = 530 bits (1365), Expect = e-149, Method: Composition-based stats. Identities = 255/510 (50%), Positives = 333/510 (65%), Gaps = 2/510 (0%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M +IIFDTTLRDGEQ+ AS++ +EK++IA LERM VDV+E GFP +S GDFE+V+ Sbjct: 1 MKDHLIIFDTTLRDGEQSPGASMTREEKVRIARQLERMRVDVIEAGFPAASNGDFEAVKA 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 +A +K S +C LAR +E DI A E+L+ A + RIHTFIATSP+H+ KLR + D+V+E Sbjct: 61 VAAAIKGSTICGLARAIEGDIRRAGEALRGANSARIHTFIATSPIHMEKKLRMSPDQVVE 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 +A+ VK AR YTDDVEFS EDAGR+ I L RV+EA I+AGA T+NIPDTVGYTMP +F Sbjct: 121 QAVKAVKFARQYTDDVEFSPEDAGRSDITFLCRVLEAVIDAGAGTVNIPDTVGYTMPQQF 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 +I L ER+PN DK I SVH H+DLGLAV NSL+AV GARQVE +NG+GERAGN S Sbjct: 181 GELIRTLRERIPNSDKVIFSVHCHNDLGLAVANSLSAVMNGARQVECTVNGLGERAGNAS 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV+MA++ R+D T I+ I S+LVS I P+ NKAIVG+ AFAH SGIH Sbjct: 241 LEEVVMAVRTRQDFFPCDTRIDSVHIVPASKLVSGITGFPVQPNKAIVGANAFAHESGIH 300 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE-SEYNLDNLYDA 359 QDGVLK+RE YEIM E +G +L L SGR A + R+ E+G + SE L+ + Sbjct: 301 QDGVLKHRETYEIMRAEDVGWGANKLLLGKHSGRNAFRSRLAELGIELESEETLNATFMR 360 Query: 360 FLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVK 419 F +LADKK +FD DL AL EH++L + S + + A++ + Sbjct: 361 FKELADKKHDIFDEDLHALVSDDA-AALQEHYKLLSLTAHSETGETPHASIVIGEEGRES 419 Query: 420 AEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVG 479 ++G+GPVDA ++AI +I VEL YS+ A G D+ G+V + +GR +G G Sbjct: 420 RAESDGSGPVDATFRAIEKILNSGVELQLYSVNAITSGTDSQGEVTVRLQKSGRIVNGNG 479 Query: 480 LATDIVESSAKAMVHVLNNIWRAAEVEKEL 509 TDIV +SAKA + LN + E Sbjct: 480 ADTDIVVASAKAYLSALNKLHSKLERAHPQ 509 >UniRef50_P48571 2-isopropylmalate synthase n=3 Tax=Buchnera aphidicola RepID=LEU1_BUCRP Length = 518 Score = 530 bits (1365), Expect = e-149, Method: Composition-based stats. Identities = 349/508 (68%), Positives = 430/508 (84%), Gaps = 1/508 (0%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+ QVIIFDTTLRDGEQALQASLSVK+KLQIAL+LE G+D++EVGFP+SSPGDF+SVQT Sbjct: 1 MNSQVIIFDTTLRDGEQALQASLSVKQKLQIALSLENTGIDIIEVGFPISSPGDFKSVQT 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I++ +KNSR+C+LARC++KDID AAE++ + AFRIH F+ATS +H+ +KL+ D++I+ Sbjct: 61 ISKNIKNSRICSLARCLDKDIDAAAEAMHSSNAFRIHIFLATSILHMESKLKKNFDQIID 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 AI VKRA YTDDVEFSCEDA RT + +L R+VE INAG TINIPDTVGYT+P E Sbjct: 121 MAITSVKRALRYTDDVEFSCEDASRTTMDNLCRIVEKLINAGVKTINIPDTVGYTVPNEL 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 + II L++RVPNIDK+IISVH H+DLG+AVGNS++A+ AGARQ+EG +NGIGERAGN + Sbjct: 181 SSIIHNLFQRVPNIDKSIISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTA 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEVI+AIKVR+D+L V T I H+EI+RTSQ++SQICN+PIP NKAIVGS AFAHSSGIH Sbjct: 241 LEEVIIAIKVREDVLGVSTKIKHKEIYRTSQIISQICNLPIPPNKAIVGSNAFAHSSGIH 300 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 QDGVLKNR+NYEIM P SIGL +++LNLTSRSGRAAVKH M EMGY+E +Y +D LY +F Sbjct: 301 QDGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKHYMTEMGYRECDYKIDELYASF 360 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 LKLADKKGQVFDYDLEALAFI +QQEE EHF L +FSVQS SN ++TA+VKL CG++ Sbjct: 361 LKLADKKGQVFDYDLEALAFINQQQEELEHFSLSFFSVQSISNGLSTASVKLLCGKKTFI 420 Query: 421 EA-ANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVG 479 E+ NGP+DA+YQA+NRIT + + L KY L AKG GKDALGQVDI+ + R+FHG+G Sbjct: 421 ESATTSNGPIDAIYQALNRITHFPIILQKYQLIAKGKGKDALGQVDILVEHKKRKFHGMG 480 Query: 480 LATDIVESSAKAMVHVLNNIWRAAEVEK 507 LATDI+ESSA+AMV+VLNNIW+A +V + Sbjct: 481 LATDIIESSAQAMVNVLNNIWKANQVNE 508 >UniRef50_A3PDH0 2-isopropylmalate synthase n=42 Tax=cellular organisms RepID=LEU1_PROM0 Length = 546 Score = 529 bits (1363), Expect = e-148, Method: Composition-based stats. Identities = 239/537 (44%), Positives = 340/537 (63%), Gaps = 18/537 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 +++IFDTTLRDGEQ+ ASL+++EKL IA L R+GVDV+E GFP +SPGDF++V I Sbjct: 5 PGRILIFDTTLRDGEQSPGASLNLEEKLAIAHQLARLGVDVIEAGFPFASPGDFKAVNKI 64 Query: 62 ARQVK---NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEV 118 A V +C LAR + DI E++ A RIHTFIATS +H+ KL+ + +V Sbjct: 65 ASAVGKEHGPTICGLARASKGDIKACYEAVSPAPKKRIHTFIATSDIHLKHKLKKSRKDV 124 Query: 119 IERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 ++ MV A++ DD+EFSCEDA R+ L V++ AI+AGATTINIPDTVG+T P Sbjct: 125 LQIVPEMVNYAKSLVDDIEFSCEDASRSDPDFLYEVIQLAISAGATTINIPDTVGFTTPS 184 Query: 179 EFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGN 238 EF +I+ + + VPNID+A+ISVH H+DLGLAV N L AV GARQ+E +NGIGERAGN Sbjct: 185 EFGNLIADINKNVPNIDEAVISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGN 244 Query: 239 CSLEEVIMAIKVRK-----------DILNVHTAINHQEIWRTSQLVSQICNMPIPANKAI 287 SLEE++MA+ VRK D TAI +EI +TS+LVS + M + NKAI Sbjct: 245 ASLEELVMALHVRKSFFNSFFKRNPDSPTPLTAIRTEEITKTSRLVSNLTGMTVQPNKAI 304 Query: 288 VGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK 347 VG+ AFAH SGIHQDGVLKNR YEI+ +++GL+ +++L SGR+AV+ R++EMGY Sbjct: 305 VGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNKISLGKLSGRSAVRARLEEMGYD 364 Query: 348 ESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIAT 407 S +L++ + F LAD+K ++ D DLEA+ + Q F+L V G+ T Sbjct: 365 LSREDLNDAFARFKDLADRKREITDRDLEAIVSE-QVQLPEAKFQLSLVQVSCGNASKPT 423 Query: 408 AAVKLACGEE--VKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVD 465 A + L E+ + G GPVDAV +A+N++ + EL+++S+ + G DALG+V Sbjct: 424 ATISLLNTEDNTEDTAVSIGTGPVDAVCEALNKLAKVPNELIEFSVKSVTEGIDALGEVT 483 Query: 466 IVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKET 522 I + + + G TD+V ++A A ++ LN + + + + + + EN+ T Sbjct: 484 IRIRRDNKIYSGHSADTDVVVAAANAYINALNRLVFSEKKNS-IHPQFDNLENSNNT 539 >UniRef50_A8FFW5 2-isopropylmalate synthase n=224 Tax=Bacilli RepID=LEU1_BACP2 Length = 517 Score = 528 bits (1359), Expect = e-148, Method: Composition-based stats. Identities = 234/514 (45%), Positives = 326/514 (63%), Gaps = 4/514 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ FDTTLRDGEQ+ +L+ +EKL IA LER+GV+++E GFP SS GDF VQ IA Sbjct: 2 RKINFFDTTLRDGEQSPGVNLNAQEKLIIAKQLERLGVNIIEAGFPASSRGDFLGVQEIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 R +KN V LARCV+ DID A E+LK R+H FIATS +H+ KL+ T +EV+E+A Sbjct: 62 RTIKNCSVAGLARCVKGDIDAAWEALKDGVEPRLHVFIATSDIHLKHKLKKTREEVVEQA 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + MVK A+ V++S EDA RT + LA +VE I+AGA+ IN+PDTVGY P E+ Sbjct: 122 VAMVKYAKERFPVVQWSAEDACRTDLDFLAEIVEKVIDAGASVINLPDTVGYLAPKEYGN 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I + E VPNID+ +S H HDDLG+AV NSLAA+ GA Q+E A+NGIGERAGN +LE Sbjct: 182 IFKYMKEHVPNIDRVNLSAHCHDDLGMAVANSLAAIENGADQIETAVNGIGERAGNAALE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E+ +A+ +RKD V + I EI RTS +VS+ M +P NKA+VG+ AFAH SGIHQD Sbjct: 242 EIAVALHIRKDFYQVESTIQLNEIKRTSDVVSKYSGMIVPRNKAVVGNNAFAHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G LK + YEI++PE +G+ L L SGR A K RM +G+K +E ++ ++ F Sbjct: 302 GFLKEKTTYEIISPELVGVTTDVLVLGKHSGRHAFKDRMKTLGFKLTEEEINKFFETFKN 361 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGE--EVKA 420 L +KK ++ D DL ++ K + + + V G+ + TA V L E EV Sbjct: 362 LTEKKKEITDDDLISIILEEKVADRKIGYEFESLQVHYGTEQMPTATVSLKNQETQEVIQ 421 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 EAA G G V+AVY + R E + L+ Y + + G G+DAL +V + + G+ G G+ Sbjct: 422 EAATGAGSVEAVYNTLERCMEERIHLLDYRIQSNGKGRDALAEVYVTVSIEGKETAGRGV 481 Query: 481 ATDIVESSAKAMVHVLNN--IWRAAEVEKELQRK 512 A D++E+SAKA V+ +N I+++ +E E Sbjct: 482 AQDVLEASAKAYVNAVNRHLIFKSNLIEIEKHHA 515 >UniRef50_D2M1E9 2-isopropylmalate synthase n=1 Tax=Bacillus cellulosilyticus DSM 2522 RepID=D2M1E9_BACS4 Length = 514 Score = 527 bits (1358), Expect = e-148, Method: Composition-based stats. Identities = 229/500 (45%), Positives = 316/500 (63%), Gaps = 2/500 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 ++ IFDTTLRDGEQ+ +L+ EKL+IA LER GVD+ME GFP SS GDFE V+ IA Sbjct: 2 SKINIFDTTLRDGEQSPGVNLNQLEKLEIAKQLERFGVDIMEAGFPASSQGDFEGVRAIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 +KN+ V LAR + DID A ++LK A R+H F+ATSP+H+ KL+ T ++VI+ A Sbjct: 62 NTIKNASVTGLARAKKSDIDYAWDALKEAVEPRLHIFLATSPIHMTYKLKKTPEQVIQTA 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + MV A VE+S EDA R+ I L +++E I+AGAT IN+PDTVGYT P E+ Sbjct: 122 VDMVSYASKNFPHVEWSAEDASRSDIHFLVKIIEKVIDAGATVINLPDTVGYTTPQEYGD 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + + E V NIDK +S H HDDLG+AV N++AAV GA QVEG +NGIGERAGN SLE Sbjct: 182 LFKYVRENVRNIDKVTLSAHCHDDLGMAVANTIAAVENGATQVEGTINGIGERAGNASLE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E+ +A+ +R D T + EI RTS LVS++ M +P NKA+VG AFAH SGIHQD Sbjct: 242 EIAVALNIRSDKYPYTTNLVLNEIKRTSDLVSKLTGMVVPPNKAVVGRNAFAHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 GVLKN YEI+TPE +G+ L L SGR A K +++++GY+ +E L + +F Sbjct: 302 GVLKNASTYEIITPELVGIQSNNLVLGKHSGRHAFKDKIEQLGYELAEDKLLEAFQSFKL 361 Query: 363 LADKKGQVFDYD-LEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLAC-GEEVKA 420 L D+K +V D D L I + + + L+ F VQ GS+++ TA V L E Sbjct: 362 LTDRKKEVTDDDLFTILTDIQTDTSDVKKYELEAFQVQYGSSNLPTATVALTTPEGERVE 421 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 A G+G V+A+Y + + + + L ++L++ G G+DAL V I N G G Sbjct: 422 TACTGSGSVEALYNTLEALIKEKIHLTDFNLSSVGQGRDALADVHIKMTVNDTPVSGRGT 481 Query: 481 ATDIVESSAKAMVHVLNNIW 500 A D++E+SAKA ++ +N ++ Sbjct: 482 AQDVLEASAKAFLNAVNRVF 501 >UniRef50_Q2IUT4 2-isopropylmalate synthase n=119 Tax=Bacteria RepID=LEU1_RHOP2 Length = 524 Score = 527 bits (1358), Expect = e-148, Method: Composition-based stats. Identities = 232/502 (46%), Positives = 324/502 (64%), Gaps = 1/502 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +VIIFDTTLRDGEQ A+++ +EKL +A L+ MGVDV+E G+P +S GDFE+V IA Sbjct: 10 DRVIIFDTTLRDGEQCPGATMTFEEKLNVARMLDDMGVDVIEAGYPFASDGDFEAVHEIA 69 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 ++ KNS +C L+R KDID AE++K AE RIHTF++TSP+H+ KL+ +V E Sbjct: 70 KRSKNSVICGLSRASHKDIDRCAEAIKPAERGRIHTFLSTSPVHMKYKLQMEAAQVYEMV 129 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 I V RARN+TDDVE+S EDA RT L R +EAAI AGATTIN+PDTVGY +P E+ Sbjct: 130 ISSVTRARNHTDDVEWSAEDATRTEFDFLCRCIEAAIKAGATTINLPDTVGYAVPEEYRE 189 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + + E VPN DKA SVH H+DLG+AV NS+A V GARQ+E +NGIGERAGN +LE Sbjct: 190 MFRKVRETVPNSDKARFSVHCHNDLGMAVANSMAGVAGGARQIECTINGIGERAGNAALE 249 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E++MA++VR+D L I + S+ VS + P+ NKAIVG AFAH SGIHQD Sbjct: 250 ELVMAMRVRQDKLPYWNNIETTMLTHASKTVSAATSFPVQYNKAIVGRNAFAHESGIHQD 309 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G++KN + YEIMTPE++G+ L + SGRA + H+++E+GYK S +++++ F Sbjct: 310 GMIKNAQTYEIMTPETVGVKGTSLVMGKHSGRAGLIHKLEELGYKLSRNQIEDVFVRFKA 369 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEA 422 LAD+K V+D D+EAL + + +L+ +V +G++ A +KL +++ E Sbjct: 370 LADRKKDVYDEDIEALVDEQLLHGQ-DQIKLNSLTVIAGTHGPQRATMKLDVDGQIRIEE 428 Query: 423 ANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLAT 482 A GNGPVDAV+ I + ++ +L Y + A G DA +V + ++ GR Sbjct: 429 AEGNGPVDAVFNCIKALVPHDAKLELYQVHAVTEGTDAQAEVSVRLSHEGRSMTARAADP 488 Query: 483 DIVESSAKAMVHVLNNIWRAAE 504 D + +SAKA + LN I + Sbjct: 489 DTLVASAKAYLGALNKIVAKRQ 510 >UniRef50_Q72JC9 2-isopropylmalate synthase n=4 Tax=Thermaceae RepID=Q72JC9_THET2 Length = 520 Score = 522 bits (1344), Expect = e-146, Method: Composition-based stats. Identities = 229/498 (45%), Positives = 310/498 (62%), Gaps = 2/498 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + + IFDTTLRDGEQ+ +LS+ +KL+IA AL ++ VD++E GFPVS P +FE+V+ IA Sbjct: 5 RHIRIFDTTLRDGEQSPGVALSLDQKLEIAQALAQLNVDIIEAGFPVSGPMEFEAVRRIA 64 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 +VK + ALAR DID AA++L+ AE RIH F + S +H+ LR T +EV+E A Sbjct: 65 TEVKGPIIAALARTHTLDIDQAAKALEKAEKPRIHVFTSASKVHLQYMLRKTEEEVLEMA 124 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 MV+ AR Y DDVEFS +D R + R+ E AI AGATTINIPDT GY P E+ Sbjct: 125 DRMVRYARRYVDDVEFSAQDVMRADWEFVKRLYEVAIEAGATTINIPDTTGYGTPQEYGA 184 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 +I + + V IIS HTHDDLG+A N+LA V GA Q+E +NGIGERAGNC+LE Sbjct: 185 LIRRIRDEVVRGRDVIISTHTHDDLGMATANALAGVENGAGQIECTINGIGERAGNCALE 244 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV+MA+ VR+D +T IN +EI+R S+LV + MP+P NKAIVG AFAH SGIHQD Sbjct: 245 EVVMALYVRRDWYKAYTRINTREIYRVSRLVERYTGMPVPPNKAIVGDNAFAHESGIHQD 304 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGY-KESEYNLDNLYDAFL 361 GV+K+R YEIM E IG L L SGRAA K ++++GY SE + L+ F Sbjct: 305 GVIKHRATYEIMDAELIGRRPAVLVLGKHSGRAAFKKALEDLGYKDLSEEEVKKLFARFK 364 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAE 421 ++A+KKG + +L+AL ++ F+L++ SGS + TA VK+ + + Sbjct: 365 EIAEKKGPLSAEELQALVESEREPTSH-FFQLEHVQFFSGSGLLPTATVKVKTPDGERVA 423 Query: 422 AANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLA 481 G+GPVDAVY+AI EL Y + A +ALGQV + + GVG++ Sbjct: 424 THTGDGPVDAVYKAIQEAIGLRPELELYRVEAITGSTEALGQVTVRLRLGELQAVGVGVS 483 Query: 482 TDIVESSAKAMVHVLNNI 499 DI+E+SA A + + Sbjct: 484 PDIIEASALAFLDAAGKL 501 >UniRef50_A3DF94 2-isopropylmalate synthase n=3 Tax=Clostridium thermocellum RepID=A3DF94_CLOTH Length = 511 Score = 515 bits (1327), Expect = e-144, Method: Composition-based stats. Identities = 217/495 (43%), Positives = 310/495 (62%), Gaps = 3/495 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ IFDTTLRDGEQ +L+++EK+ IA L R+GVDV+E GFP++SPGDFE+VQ IA Sbjct: 2 RRIRIFDTTLRDGEQTPGVNLNIQEKVDIAKQLARLGVDVIEPGFPLTSPGDFEAVQRIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 R+V+ +C +R + +DID +++K A+ H FI++S + I +L T +V+E Sbjct: 62 REVEGPYICGFSRAIIRDIDETWKAIKDAQKKCFHIFISSSDIQIKHQLGKTEKDVLEIV 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 V A+ YTD+VE+S DA RT + L V+EAAI+ GAT INIPDTVGY P EF Sbjct: 122 KSTVYHAKQYTDEVEYSPMDASRTRLEFLYEVIEAAIDNGATVINIPDTVGYATPIEFGE 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 +I + + V NIDKAIISVH H+DLG+AV NS+ A GA+Q+E +NG+GERAGN +LE Sbjct: 182 LIQKIRKNVRNIDKAIISVHCHNDLGMAVANSIVAAMNGAQQIECTINGVGERAGNAALE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV+ I RKD L T I+ ++++TS++VS+ +PIP NK IVG F H SGIHQD Sbjct: 242 EVVTHIAARKDYLGFETGIDLSQLYKTSKIVSRYMGIPIPVNKPIVGKNVFTHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 GVLK R YE++ P +G + + L SGR A+K +++GY E L+ L++ F K Sbjct: 302 GVLKERSTYEVIDPRLVGRDDSVILLGKHSGRHALKVEAEKLGYDLDEERLNKLFNDFKK 361 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLAC-GEEVKAE 421 L D K V DLE+L + E + L+ V SG+ + +A V + + Sbjct: 362 LTDVKKNVTTADLESLIIESAAKAVEEAYVLEKIRVVSGNIETPSAKVVIKDSKGNLLEA 421 Query: 422 AANGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVG 479 GNGPVDAV++AIN + + N+ L KYS++A ++LG+V + + + G+G Sbjct: 422 EQTGNGPVDAVFKAINSVIKETENLTLYKYSVSAVTEEMESLGEVSVTLREKEKLYTGIG 481 Query: 480 LATDIVESSAKAMVH 494 TDI+ SSA A + Sbjct: 482 THTDIITSSAIAYID 496 >UniRef50_Q9C550 2-isopropylmalate synthase 2, chloroplastic n=59 Tax=cellular organisms RepID=LEU12_ARATH Length = 631 Score = 512 bits (1319), Expect = e-143, Method: Composition-based stats. Identities = 235/537 (43%), Positives = 321/537 (59%), Gaps = 30/537 (5%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 V IFDTTLRDGEQ+ A+L+ KEKL IA L ++GVD++E GFP +S DFE+V+TI Sbjct: 84 PNYVRIFDTTLRDGEQSPGATLTSKEKLDIARQLAKLGVDIIEAGFPAASKDDFEAVKTI 143 Query: 62 ARQVKNSR--------VCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRS 113 A V N+ +C L+RC +KDI+ A E++K A+ RIHTFIATS +H+ KL+ Sbjct: 144 AETVGNTVDENGYVPVICGLSRCNKKDIETAWEAVKYAKRPRIHTFIATSDIHLKYKLKK 203 Query: 114 TLDEVIERAIYMVKRARNYTD-DVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTV 172 + +EVIE A MV+ AR+ DVEFS EDAGR+ L ++ I AGATT+NIPDTV Sbjct: 204 SKEEVIEIARNMVRFARSLGCEDVEFSPEDAGRSEREYLYEILGEVIKAGATTLNIPDTV 263 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G T+P EF +I+ + P I IIS H +DLGL+ N+L+ H+GARQVE +NGI Sbjct: 264 GITLPSEFGQLIADIKANTPGIQNVIISTHCQNDLGLSTANTLSGAHSGARQVEVTINGI 323 Query: 233 GERAGNCSLEEVIMAIKVRKD--ILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGS 290 GERAGN SLEEV+MAIK R D + + T I+ + I TS++V + M +KAIVG+ Sbjct: 324 GERAGNASLEEVVMAIKCRGDHVLGGLFTGIDTRHIVMTSKMVEEYTGMQTQPHKAIVGA 383 Query: 291 GAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQ---LNLTSRSGRAAVKHRMDEMGYK 347 AFAH SGIHQDG+LK++ YEIM+PE IGL + + L SGR A+K R++E+GY Sbjct: 384 NAFAHESGIHQDGMLKHKGTYEIMSPEEIGLERSNDAGIVLGKLSGRHALKDRLNELGYV 443 Query: 348 ESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIAT 407 + L NL+ F +A++K +V D DL AL Q E ++L + G+ ++T Sbjct: 444 LDDGQLSNLFWRFKAVAEQKKRVTDADLIALVSDEVFQPEA-VWKLLDMQITCGTLGLST 502 Query: 408 AAVKLAC-GEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDI 466 + VKLA + + G GPVDA Y+A++ I + L++YS+ A G DA+ + Sbjct: 503 STVKLADSDGKEHVACSVGTGPVDAAYKAVDLIVKEPATLLEYSMNAVTEGIDAIATTRV 562 Query: 467 VANYN--------------GRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKEL 509 + + R F G G DIV SS KA V LN + E L Sbjct: 563 LIRGDNNYSSTNAVTGESVERTFSGTGAGMDIVVSSVKAYVGALNKMLGFKEHTSTL 619 >UniRef50_A6EER4 2-isopropylmalate synthase n=3 Tax=Sphingobacteriales RepID=A6EER4_9SPHI Length = 502 Score = 511 bits (1315), Expect = e-143, Method: Composition-based stats. Identities = 233/499 (46%), Positives = 323/499 (64%), Gaps = 1/499 (0%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 +V +FDTTLRDGEQ LS EK++IA ALE +GVDV+E GFP+SSPGDF+SV + Sbjct: 5 PNRVYVFDTTLRDGEQVPGCQLSTPEKIEIAKALEALGVDVIEAGFPISSPGDFQSVVEM 64 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 ++ V+ +CAL R + DID A +L+ A+ RIHT I +S MHI K ST ++++ER Sbjct: 65 SKAVQEPIICALTRANKGDIDSAVAALQYAKRPRIHTGIGSSDMHIKYKFNSTREKILER 124 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 A+ VK A+ + +D+EF EDAGR LA++VEA I AGAT +NIPDT GY +P ++ Sbjct: 125 AVDAVKYAKQFVEDIEFYAEDAGRADNVFLAQMVEAVIAAGATVVNIPDTNGYCLPDQYG 184 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 I L E V NID+AIISVH H+DLGLA N+LA + GARQ+E +NGIGERAGN +L Sbjct: 185 SKILYLKENVKNIDQAIISVHCHNDLGLATANTLAGIVNGARQIECTINGIGERAGNTAL 244 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EEV+M +K + ++T IN + S +VS++ MP+ NKAI+G AFAHSSGIHQ Sbjct: 245 EEVVMILKTHHAL-GLNTNINAKHFSDISNMVSRMMRMPVQPNKAIIGQNAFAHSSGIHQ 303 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 DG LK+RENYEIM PE +G+N + LT+RSGR A+KH ++ +GY+ NLD +Y+ FL Sbjct: 304 DGFLKHRENYEIMNPEDVGINSADIILTARSGRHALKHHLERLGYEIERLNLDQVYERFL 363 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAE 421 LAD+K + D D+ +L GK+ ++L V G TA++KL K Sbjct: 364 ILADEKKAISDDDIHSLMSDGKEDSYKNGYKLTLLQVLCGDPLSPTASIKLEHNGVEKEA 423 Query: 422 AANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLA 481 A+GNGPV+A AI I ++EL ++++ A G D + +V+I G+ + G G + Sbjct: 424 MASGNGPVNATINAIQSIVGADIELKEFTIQAVNGGSDDVSKVNIRIASEGKSYVGHGFS 483 Query: 482 TDIVESSAKAMVHVLNNIW 500 TDIV++SA A + +N Sbjct: 484 TDIVKASAYAYLDAMNKFM 502 >UniRef50_Q5F8D4 2-isopropylmalate synthase n=73 Tax=cellular organisms RepID=LEU1_NEIG1 Length = 517 Score = 507 bits (1306), Expect = e-142, Method: Composition-based stats. Identities = 227/499 (45%), Positives = 324/499 (64%), Gaps = 1/499 (0%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 + +VIIFDTTLRDGEQ+ A+++ +EK+++A LE++G D++E GF +SPGDFE+V I Sbjct: 4 ANRVIIFDTTLRDGEQSPGAAMTKEEKIRVARQLEKLGADIIEAGFAAASPGDFEAVNAI 63 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 A+ + S VC+L+R +E+DI A +++ A RIHTFIATSP+H+ KL+ +VIE Sbjct: 64 AKTITKSTVCSLSRAIERDIRQAGKAVAPAPKKRIHTFIATSPIHMEYKLKMKPKQVIEA 123 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 A+ VK AR YTDDVEFSCEDA R+ I LA + A I AGATTINIPDTVGY++P++ Sbjct: 124 AVKAVKIAREYTDDVEFSCEDALRSQIDFLAEICGAVIEAGATTINIPDTVGYSIPYKTE 183 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 L + PN K + S H H+DLGLAV NSLAA+ GARQVE +NG+GERAGN S+ Sbjct: 184 EFFRELIAKTPNGGKVVWSAHCHNDLGLAVANSLAALKGGARQVECTVNGLGERAGNASV 243 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EE++MA+KVR D+ + T I+ +I +S+LVS I P+ NKAIVG+ AF+H SGIHQ Sbjct: 244 EEIVMALKVRHDLFGLETGIDTTQIVPSSKLVSTITGYPVQPNKAIVGANAFSHESGIHQ 303 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE-SEYNLDNLYDAF 360 DGVLK+RE YEIM+ ES+G + +L+L SGR A K ++ ++G + SE L+ + F Sbjct: 304 DGVLKHRETYEIMSAESVGWSANRLSLGKLSGRNAFKTKLADLGIELESEEALNAAFARF 363 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 +LADKK ++FD DL AL E ++ + + + + A + E K Sbjct: 364 KELADKKREIFDEDLHALVSDEMGNMNAESYKFISQKISTETGEEPRADIVFGIKGEEKR 423 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 +A G+GPVDA+++AI + + L YS+ A G ++ G+ + R +G G Sbjct: 424 ASATGSGPVDAIFKAIESVAQSGATLQIYSVNAVTQGTESQGETSVRLARGNRVVNGQGA 483 Query: 481 ATDIVESSAKAMVHVLNNI 499 TDI+ ++AKA + L+ + Sbjct: 484 DTDILAATAKAYLSALSKL 502 >UniRef50_B8J824 2-isopropylmalate synthase n=7 Tax=Bacteria RepID=B8J824_ANAD2 Length = 523 Score = 506 bits (1304), Expect = e-142, Method: Composition-based stats. Identities = 241/516 (46%), Positives = 333/516 (64%), Gaps = 2/516 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 Q+V IFDTTLRDGEQ+ AS+++ +KLQ+A AL +GVDV+E GF +SPGD E++Q + Sbjct: 6 QRVTIFDTTLRDGEQSPGASMNLGQKLQVARALRDLGVDVIEAGFAAASPGDLEAIQAVG 65 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 RQV+ V +L+RC + DI+ + ++L A R H F+ATSP+H KL+ DE+I+R+ Sbjct: 66 RQVEGPIVASLSRCNKGDIEASWKALADAPRRRCHVFLATSPIHRDFKLKLAKDEIIKRS 125 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + VK AR DDVEFS ED+ RT + LA VVE I AG T+NIPDTVGY +P +A Sbjct: 126 VDGVKLAREKFDDVEFSAEDSARTELEFLAEVVERVIEAGVGTVNIPDTVGYALPSTYAE 185 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I L + V I+KA+ISVH H+DLG+AV NSLA V GARQVE +NGIGERAGN SLE Sbjct: 186 TIRYLRKHVRGIEKAVISVHCHNDLGMAVANSLAGVLEGARQVECTINGIGERAGNASLE 245 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E++MA K R D+L V T + + ++ TS+LVSQ+ + + NKAIVG AFAH +GIHQ Sbjct: 246 EIVMAFKTRHDVLGVTTGVQTERLFPTSRLVSQVTGLHVQRNKAIVGQNAFAHEAGIHQH 305 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G+L NRE YEIM PE +G + QL L SGR A+K R+ +GY+ E +D ++ F Sbjct: 306 GMLTNRETYEIMRPEEVGFARSQLVLGKHSGRHALKDRLLALGYQLDEAQIDKVFADFKV 365 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPE-HFRLDYFSVQSGSNDIATAAVKLA-CGEEVKA 420 LADKK ++D D+EAL G+ + + L+ S SG+ + A+V L E Sbjct: 366 LADKKKDIYDADIEALVVHGQILGKGSVAWELEALSTTSGTGTLPCASVALRSAAGERIQ 425 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 EAA G+GPVDAVY+AI ++T +++L Y + + G+DA G+V I + + G L Sbjct: 426 EAAAGDGPVDAVYRAIEKVTGISLKLRDYQIASVSRGEDAQGEVSIEVEHPTGVYRGRAL 485 Query: 481 ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHN 516 +TDI+E SA+A + V+N I E + +A+ Sbjct: 486 STDIIEGSARAFLDVVNRIALKMPPPTESEARAEMG 521 >UniRef50_B6YRN0 2-isopropylmalate synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YRN0_AZOPC Length = 504 Score = 506 bits (1303), Expect = e-142, Method: Composition-based stats. Identities = 241/498 (48%), Positives = 330/498 (66%), Gaps = 3/498 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 V IFDTTLRDGEQ L+ EK+Q+A +LE +GVD++E GFP+SSPGDF SV I+ Sbjct: 9 NSVFIFDTTLRDGEQVPGCQLNTIEKIQVAQSLESLGVDIIEAGFPISSPGDFNSVIEIS 68 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 + V + +CAL R +EKDID+AAESL+ A+ RIHT I TSP HI K ST DE++ERA Sbjct: 69 KSVTWTIICALTRAIEKDIDIAAESLQYAKRKRIHTGIGTSPYHIKYKFNSTQDEILERA 128 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + VK A+ Y +D+EF CEDAGRT LAR+VEA I AGA +NIPDT GY +P E+ Sbjct: 129 VASVKYAKKYVEDIEFYCEDAGRTDNVYLARIVEAVIKAGAKVVNIPDTTGYCLPEEYGA 188 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I L + V I I+S H H+DLG+A N+++ + GARQVE +NGIGERAGN SLE Sbjct: 189 KIKFLMDNVKGIQNVILSTHCHNDLGMATANTISGIINGARQVEVTINGIGERAGNTSLE 248 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV+M IK K++ + T IN + I+ S+++S + NMP+ NKAIVG AFAHSSGIHQD Sbjct: 249 EVVMIIKSHKELN-IGTNINTKHIYPISRMISSLMNMPVQPNKAIVGRNAFAHSSGIHQD 307 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G+LKNRENYEI+ P+ IG++ + LT+RSGRAA+K+R++ +G + S+ LD++Y+ FLK Sbjct: 308 GILKNRENYEIIDPKDIGIDNNIIALTARSGRAALKYRLNILGIELSQKKLDDIYEEFLK 367 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEA 422 LAD K + D D+ LA GK + E RL+Y V SG + A++ L E A Sbjct: 368 LADYKKNINDDDILMLA--GKDRTESNRIRLEYLQVTSGVGILPVASICLNIAGEKFEAA 425 Query: 423 ANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLAT 482 A+GNGPVDA +A+ +I + + ++ + A G + +G+V + YN ++G T Sbjct: 426 ASGNGPVDAAIRAVKQIIHRQMVIQEFLIQAINKGSNDVGKVHMQVKYNDVNYYGFAANT 485 Query: 483 DIVESSAKAMVHVLNNIW 500 DIV +S +A + +N Sbjct: 486 DIVAASVEAFIDAINKFV 503 >UniRef50_A6LDN1 2-isopropylmalate synthase n=6 Tax=Bacteria RepID=A6LDN1_PARD8 Length = 500 Score = 502 bits (1294), Expect = e-141, Method: Composition-based stats. Identities = 246/501 (49%), Positives = 324/501 (64%), Gaps = 4/501 (0%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 MS ++ IFDTTLRDGEQ L+ EK+Q+A ALE++GVDV+E GFPVSSPGDF+SV Sbjct: 1 MSDRLFIFDTTLRDGEQVPGCQLNTVEKIQVAKALEQLGVDVIEAGFPVSSPGDFKSVVE 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I++ V +CAL R VEKDIDVAAE+L+ A+ RIHT I TS HI K ST +E+IE Sbjct: 61 ISKAVTWPTICALTRAVEKDIDVAAEALRFAKRGRIHTGIGTSDSHIKYKFNSTREEIIE 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 RAI K A+ Y +DVEF CEDAGRT LARVVEA I AGAT +NIPDT GY +P E+ Sbjct: 121 RAIAATKYAKKYVEDVEFYCEDAGRTDNEYLARVVEAVIKAGATVVNIPDTTGYCLPDEY 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 I L E V + AI+S H H+DLG+A N++ V GARQVE +NGIGERAGN S Sbjct: 181 GAKIKYLMEHVDGVHNAILSTHCHNDLGMATANTVQGVLNGARQVEVTINGIGERAGNTS 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV M K K+ + T I +I+ TS++VS + NMP+ NKAIVG AFAHSSGIH Sbjct: 241 LEEVAMVFKSHKERD-IITNITTNKIYSTSRMVSSLMNMPVQPNKAIVGRNAFAHSSGIH 299 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 QDGVLKN + YEI+ P+ +G++ + LT+RSGRAA+KHR+ +G + LD +YD F Sbjct: 300 QDGVLKNAQTYEIIDPKDVGIDDNAIVLTARSGRAALKHRLHVLGVDLEQEKLDKVYDEF 359 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 LKLAD+K + D D+ L +GK + +L+Y V SG + A++ L + Sbjct: 360 LKLADRKKDINDDDV--LMLVGKDRTATHRIKLEYLQVTSGVGVQSVASICLNLSGVRRY 417 Query: 421 EAANGNGPVDAVYQAINRIT-EYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVG 479 EAA GNGPVDA +A+ + ++ + ++ + A G D G+V + YNG ++G Sbjct: 418 EAAAGNGPVDAGIKAVKKAISNSDMTIQEFLIQAINKGSDDTGKVHMQVEYNGATYYGFS 477 Query: 480 LATDIVESSAKAMVHVLNNIW 500 TDI+ +S +A V +N Sbjct: 478 ANTDIIAASVEAFVDAINKFI 498 >UniRef50_C7JAV8 2-isopropylmalate synthase n=8 Tax=Acetobacter pasteurianus RepID=C7JAV8_ACEP3 Length = 547 Score = 498 bits (1282), Expect = e-139, Method: Composition-based stats. Identities = 231/510 (45%), Positives = 310/510 (60%), Gaps = 5/510 (0%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 +VI+FDTTLRDGEQ+ S+++ EKL++A AL +GVDV+E GFPV+S GDFESV I Sbjct: 36 PDRVIVFDTTLRDGEQSPGFSMNLAEKLRMAEALANLGVDVIEAGFPVASKGDFESVNEI 95 Query: 62 ARQVKNSRVCALAR-CVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 A+ K S +CALAR KDI A E+L AE RIH FI+TSP+H+ KLR + V+E Sbjct: 96 AKNTKGSVICALARSGGVKDIAAAGEALAPAERKRIHNFISTSPLHMKYKLRMEPETVLE 155 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 ARN TDDVE+S ED RT L R VEAAI AGATTINIPDTVGY P + Sbjct: 156 LITSGNAAARNLTDDVEWSAEDGSRTEPDFLCRCVEAAIKAGATTINIPDTVGYATPEDM 215 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 I S L +RVP D+ I S H H+DLGLAV N+LA++ GARQVE +NGIGERAGN + Sbjct: 216 EKIFSMLRQRVPGADQVIFSAHNHNDLGLAVANTLASIRGGARQVECTINGIGERAGNAA 275 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEE++MA++ R D T I+ + + + S++++ I + + NKAIVG AFAH SGIH Sbjct: 276 LEEIVMALRTRHDQYPFTTGIHTEGLLKVSRMLATITSFDVQPNKAIVGRNAFAHESGIH 335 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK-ESEYNLDNLYDA 359 QDGVLKN YEIMTPES+G + L + SGRAA + ++ +GY+ E L+ + Sbjct: 336 QDGVLKNAATYEIMTPESVGWTRSSLVMGKHSGRAAFRDKLKVLGYEGMDETRLNEAFTR 395 Query: 360 FLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVK 419 F LAD+K V+D D+ AL + + + R S++S S + ++L+ + Sbjct: 396 FKDLADRKKVVYDDDIIALVDDEAR--DHDRIRFGALSLKSISGQPSEVDLELSVDGKAI 453 Query: 420 AEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVG 479 A GNGPVDA + A+ + + L +S+ A G DA + + G+ G G Sbjct: 454 EAKATGNGPVDAAFNALRKAFPHEARLALFSVGAVTEGTDAQARTTVRLEEAGKMVDGQG 513 Query: 480 LATDIVESSAKAMVHVLNNIW-RAAEVEKE 508 D V S+ +A VH LN + + A E E Sbjct: 514 ADADTVVSAVRAYVHALNKLLVKRARTEPE 543 >UniRef50_B3DX88 2-isopropylmalate synthase n=12 Tax=Bacteria RepID=LEU1_METI4 Length = 506 Score = 496 bits (1277), Expect = e-139, Method: Composition-based stats. Identities = 241/502 (48%), Positives = 343/502 (68%), Gaps = 4/502 (0%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 + ++I+FDTTLRDGEQ AS++ ++KL++A L R+GVDV+E GFPV S GDFESV I Sbjct: 5 ANRLIVFDTTLRDGEQCPGASMTSRQKLEVAKQLARLGVDVIEAGFPVISQGDFESVSEI 64 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAF-RIHTFIATSPMHIATKLRSTLDEVIE 120 A QVK ++C LARC+ KDI+ AAE+LK A RIH F+ATS +H KL +E++ Sbjct: 65 AAQVKGPKICGLARCLPKDIEAAAEALKAAADAARIHVFLATSQIHRRFKLAKDEEEIVR 124 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 A+ V+ A+ Y DVEFS EDA RT LA++++ I AGATT+NIPDTVGY +P EF Sbjct: 125 IAVEGVRLAKRYVQDVEFSAEDASRTEPEFLAKIIQKVIEAGATTVNIPDTVGYAVPEEF 184 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 A +I L++ V +IDK ++SVH H+DLGLAV NSLAA+ AGARQVEG +NGIGERAGN + Sbjct: 185 ASLIRYLFDHVQDIDKVVVSVHCHNDLGLAVSNSLAAIKAGARQVEGTINGIGERAGNAA 244 Query: 241 LEEVIMAIKVRKDIL-NVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 LEE+IMA+ R D + T I +EI RTS+LVS++ + + NKA+VG AFAH++GI Sbjct: 245 LEEIIMALHTRPDAFGKIETGIQLKEILRTSRLVSRMSGLAVQRNKAVVGENAFAHAAGI 304 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 HQDG+LK RE YEI+ P+ IG Q +L LT SGRAA+++R+ +G++ + +DN++ Sbjct: 305 HQDGILKKRETYEIIDPKIIGWEQSELPLTKHSGRAALENRLKILGFELEKEEIDNIFSQ 364 Query: 360 FLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVK 419 F ++ DKK ++D DL +L G+ E + L+Y +V S I A +KL GEEV Sbjct: 365 FKQIGDKKKFIYDDDLVSLV-EGQISRIKETYELEYVAVTVCSGGIPMATIKLRHGEEVL 423 Query: 420 AEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRR-FHGV 478 +A+ G+G VDA +A++RIT + LV+Y + + GKDA+G+V + N++ ++ Sbjct: 424 VDASTGDGAVDAAMKAVDRITGQHGHLVEYEVKSVTEGKDAIGEVTVKVNFDSKKLVTAK 483 Query: 479 GLATDIVESSAKAMVHVLNNIW 500 +TD++E+S KA ++ +N Sbjct: 484 AASTDVIEASIKAYLNAVNKAL 505 >UniRef50_Q58787 (R)-citramalate synthase n=5 Tax=Methanococcales RepID=CIMA_METJA Length = 491 Score = 491 bits (1265), Expect = e-137, Method: Composition-based stats. Identities = 182/500 (36%), Positives = 276/500 (55%), Gaps = 16/500 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V IFDTTLRDGEQ SL+ +KL+IA L+ +GVDV+E G ++S G+ E ++ I ++ Sbjct: 3 VRIFDTTLRDGEQTPGVSLTPNDKLEIAKKLDELGVDVIEAGSAITSKGEREGIKLITKE 62 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 N+ +C+ R + DID A E + +H + TSP+H+ KLR T DEV+E A+ Sbjct: 63 GLNAEICSFVRALPVDIDAALE----CDVDSVHLVVPTSPIHMKYKLRKTEDEVLETALK 118 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 V+ A+ + VE S EDA R+ + L ++ GA + + DTVG P + + Sbjct: 119 AVEYAKEHGLIVELSAEDATRSDVNFLIKLFNEGEKVGADRVCVCDTVGVLTPQKSQELF 178 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + E V +SVH H+D G+A N+ +AV GA Q +NGIGERAGN SLEEV Sbjct: 179 KKITENV----NLPVSVHCHNDFGMATANTCSAVLGGAVQCHVTVNGIGERAGNASLEEV 234 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 + A+K+ T I ++++ S++VS++ +P+P NKAIVG AFAH +GIH DG+ Sbjct: 235 VAALKILYG---YDTKIKMEKLYEVSRIVSRLMKLPVPPNKAIVGDNAFAHEAGIHVDGL 291 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 +KN E YE + PE +G N+ ++ L SGR A+K+++D MG S+ L+ +Y+ + Sbjct: 292 IKNTETYEPIKPEMVG-NRRRIILGKHSGRKALKYKLDLMGINVSDEQLNKIYERVKEFG 350 Query: 365 DKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVK--AEA 422 D + D DL A+ + E +LD +V SG+ A+VKL E E Sbjct: 351 DLGKYISDADLLAIVREVTGKLVEEKIKLDELTVVSGNKITPIASVKLHYKGEDITLIET 410 Query: 423 ANGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 A G GPVDA A+ + +++LV+Y + A G G DAL +V + Sbjct: 411 AYGVGPVDAAINAVRKAISGVADIKLVEYRVEAIGGGTDALIEVVVKLRKGTEIVEVRKS 470 Query: 481 ATDIVESSAKAMVHVLNNIW 500 DI+ +S A++ +N + Sbjct: 471 DADIIRASVDAVMEGINMLL 490 >UniRef50_O27525 2-isopropylmalate synthase 2 n=22 Tax=Archaea RepID=LEU12_METTH Length = 505 Score = 491 bits (1265), Expect = e-137, Method: Composition-based stats. Identities = 206/503 (40%), Positives = 294/503 (58%), Gaps = 15/503 (2%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + + V IFDTTLRDGEQ +L+V+EK IA L+ +GVD +E GFP +SPG+ S++ Sbjct: 12 LPENVRIFDTTLRDGEQTPGVALTVEEKTGIARKLDALGVDTIEAGFPAASPGEMNSIRR 71 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I + +C LAR + +DID A + IHTFI TSP+H KL+ + DE+I+ Sbjct: 72 IVELGLEANICGLARVLREDIDAAID----CGVDYIHTFIGTSPLHREYKLKMSPDEIID 127 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 RA++ V+ A + VEFS EDA RT L V AA +AGA IN+PDTVG +P Sbjct: 128 RAVFGVEYAAEHGLKVEFSAEDATRTEFDYLVEVYRAAEDAGAEIINVPDTVGVMIPRAM 187 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 ++S L E + + ISVH H+D GLAV NSLAAV AGA QV +NG+GERAGN + Sbjct: 188 NHLVSRLKEEL----RVPISVHCHNDFGLAVANSLAAVEAGASQVHATVNGLGERAGNAA 243 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV+MA+ R D+ I E+ S+ VS+I + +P NKAIVG AFAH +GIH Sbjct: 244 LEEVVMALITRYDLPV---DIRTVELVNISEFVSKITGVRMPPNKAIVGENAFAHEAGIH 300 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 GVL+ E YE +TPE +G + ++ L +G A++ ++ E G + E LY+ Sbjct: 301 VHGVLEKAETYEPITPEMVGHKR-RIVLGKHTGANALRSKLQEYGIEMKEEQFCTLYEQV 359 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 +L DK ++ D DL A+A + E +L+ +V +G + + TA VKL G+EVK Sbjct: 360 KRLGDKGKRITDADLRAMAVTILGKASREIVKLEGIAVMTGESVMPTATVKLRIGDEVKT 419 Query: 421 EAANGNGPVDAVYQAINRITEY--NVELVKYSLTAKGHGKDALGQVDIVANYN-GRRFHG 477 + G GPVDA AI + ++EL +Y++ A G +AL +V +V + G + G Sbjct: 420 TSMTGVGPVDAAINAIQSLVSETADIELDEYNIEAITGGTNALAEVFVVMSDGEGNKATG 479 Query: 478 VGLATDIVESSAKAMVHVLNNIW 500 DIV +S +A++ +N I Sbjct: 480 RSTREDIVMASVEAVLDAINKIL 502 >UniRef50_D0MYD7 2-isopropylmalate synthase n=2 Tax=Phytophthora infestans T30-4 RepID=D0MYD7_PHYIN Length = 576 Score = 490 bits (1261), Expect = e-137, Method: Composition-based stats. Identities = 235/535 (43%), Positives = 323/535 (60%), Gaps = 35/535 (6%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++++FDTTLRDGEQ+ A+L+ KEKL IA AL +GVDV E GFP+SSPGDF++V IA Sbjct: 32 ERLVLFDTTLRDGEQSPGATLNFKEKLDIARALSTLGVDVCEAGFPISSPGDFDAVSAIA 91 Query: 63 RQV----------KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLR 112 +++ + +C LAR +EKDI +++K A RIHTF+ATS +H+ KL+ Sbjct: 92 KEIGPITAGRPTGEPMTICGLARAMEKDIQRCYDAVKHAPKHRIHTFLATSDIHLQYKLK 151 Query: 113 STLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTV 172 + DE I RA+ VK A++ T DVEFS EDAGR+ L V+ I AGATT+NIPDTV Sbjct: 152 ISRDECIRRAVDAVKFAKSLTPDVEFSTEDAGRSDPDFLCDVLAEVIKAGATTLNIPDTV 211 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 GYT+P E+ + S L + DKAI S H H+DLGLA N+LAAV GARQ E +NGI Sbjct: 212 GYTVPGEYGSLFSYLIDNTEGSDKAIFSTHCHNDLGLATANTLAAVQGGARQAEVTINGI 271 Query: 233 GERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 GERAGN +LEE++MA+K R V+T+++ +I R S++VS M I NKAIVGS A Sbjct: 272 GERAGNTALEELVMALKTRPQHFPVYTSVDSTQITRCSRMVSHYTGMSIQPNKAIVGSNA 331 Query: 293 FAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGY-KESEY 351 FAH SGIHQDGVLK++ YEIM PES+GL++ ++ L SGR A R+ ++GY + Sbjct: 332 FAHESGIHQDGVLKHQATYEIMLPESVGLSENKMVLGKHSGRHAYSKRLQQLGYTNLTPE 391 Query: 352 NLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVK 411 LD + F LAD+K V D D+EA+ + E + L V +G+ TA V Sbjct: 392 ELDYYVEKFKVLADEKKTVTDADMEAIVSDELFKPET-FWTLQSVHVTAGNLVKPTATVT 450 Query: 412 L-ACGEEVKAEAANGNGPVDAVYQAINRITEYN-VELVKYSLTAKGHGKDALGQVDIVAN 469 L + +EAA G GP+DA+Y AI R T ++L +S+ + G ALG+V + Sbjct: 451 LAHKDGQEVSEAAMGTGPIDAIYVAIKRATGMESIKLNDFSVESVTDGTYALGEVTVRVQ 510 Query: 470 YN---------------------GRRFHGVGLATDIVESSAKAMVHVLNNIWRAA 503 + R+F G G TDI+ +SA A V+ +N + + Sbjct: 511 EDKEEEEKTEGEKHVNAQTGVTRDRQFVGHGANTDILVASATAYVNAVNRMMASQ 565 >UniRef50_B4SI67 2-isopropylmalate synthase n=45 Tax=Xanthomonadaceae RepID=LEU1_STRM5 Length = 528 Score = 487 bits (1254), Expect = e-136, Method: Composition-based stats. Identities = 220/520 (42%), Positives = 314/520 (60%), Gaps = 10/520 (1%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 + ++ IFDTTLRDGEQ+ S+S +KL +A AL+ +GVD++E GFP SS D +++ I Sbjct: 9 TPRIRIFDTTLRDGEQSPGCSMSPPQKLVMARALDELGVDIIETGFPASSQSDRDAMALI 68 Query: 62 ARQVKNSRVC--ALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 R+++ + L+RC++ DI+ +A +L+ A R+H F++TSP+H KLR T ++V+ Sbjct: 69 GRELRRPSLSLAVLSRCLQADIETSARALEAAANPRLHVFLSTSPLHREHKLRMTREQVL 128 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE 179 E V AR+Y DDVEFS EDA RT + L V AAI+AGATTIN+PDTVG+T P E Sbjct: 129 ESVRKHVSLARSYIDDVEFSAEDATRTELDYLIEVSRAAISAGATTINLPDTVGFTTPEE 188 Query: 180 FAGIISGL---YERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERA 236 + + VPN I S H H+DLGLAV NSLAA+ GARQVE +NGIGERA Sbjct: 189 IREMFQQVIAGVADVPNAANVIFSAHCHNDLGLAVANSLAAIEGGARQVECTVNGIGERA 248 Query: 237 GNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHS 296 GNCSLEE+ M +KVR+ ++IN I TSQL+ ++ MP+ NKAIVG+ AFAH Sbjct: 249 GNCSLEEIAMVLKVRQAFYEQDSSINTPRIVGTSQLLQRLVGMPVQRNKAIVGANAFAHE 308 Query: 297 SGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNL 356 SGIHQ G+L++R YEIM PE +G Q+ L SGRAAV+ R+ +G+ E L + Sbjct: 309 SGIHQHGMLRHRGTYEIMRPEDVGWEDSQMVLGRHSGRAAVEARLRALGFWLEEDELKLV 368 Query: 357 YDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLAC-G 415 ++ F L +++ V D DL+ L G + +RL ++ S A A V+L+ Sbjct: 369 FEQFKGLCEQQRVVTDADLQTLMQGGSNA---QGYRLASMTI-SDVGSRANALVELSDPD 424 Query: 416 EEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRF 475 AE A G+GPVDA++ A++ T + L Y + + G G DA G+ ++ + G + Sbjct: 425 GNRVAETAQGDGPVDALFGALSAATGVQLMLDSYHVHSVGIGADARGEANLSVRHEGVEY 484 Query: 476 HGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQH 515 G G + DI+E+SA A + V N + R + +A Sbjct: 485 DGTGTSKDIIEASALAWLDVANRLLRQRQANAASTTEAPA 524 >UniRef50_D2RHN2 Isopropylmalate/citramalate/homocitratesynthase n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RHN2_ARCPR Length = 498 Score = 487 bits (1253), Expect = e-136, Method: Composition-based stats. Identities = 182/510 (35%), Positives = 282/510 (55%), Gaps = 18/510 (3%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + + +FDTTLRDGEQ SL V K+QIA L+++GVDV+E GFP +S G+FE+V+ IA Sbjct: 2 RTIKVFDTTLRDGEQMPGVSLPVNYKIQIAKQLDKLGVDVIEAGFPSASKGEFEAVKEIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 N+++C LAR V+KDID A + A+ +H FI TS + + ++ T DE+++ + Sbjct: 62 NLGLNAKICGLARVVKKDIDQAIK----ADVDIVHVFIPTSKIQVEHTIKKTPDEIVQLS 117 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + V+ +++ + FS DA RT + L R+ +A AG IN+PDTVG PF F Sbjct: 118 VDAVEYVKSHGVECMFSAMDATRTEMDFLKRIYKAVEEAGVDIINVPDTVGIATPFRFYD 177 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 +I L E + I VH H+D GLA N+ AAV AGA +V+ +NG+GERAGN LE Sbjct: 178 MIKKLKEHL----NVPIDVHCHNDFGLATANTYAAVLAGADEVQVTVNGLGERAGNAPLE 233 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV+ + T I + + TS+LV ++ + +P NK IVG AF+H SGIH Sbjct: 234 EVVALLYAEG----FKTNIRMEYLVETSRLVERLTGVKMPPNKPIVGENAFSHESGIHAH 289 Query: 303 GVLKNRENYEI--MTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 GVLK+ +E +TPE +G + ++ + +GR +K +++ GY + L + Sbjct: 290 GVLKDARTFEPGIITPEMVGHKR-RIVVGKHAGRHQIKKILEDAGYVVDDEKLSIIVQKV 348 Query: 361 LKLADKKGQVFDYDLEALAF--IGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEV 418 +L DK +V D DL A+A +G+ E+ +D +V +G+ TA + E Sbjct: 349 KELGDKGKKVTDLDLFAIAESVLGEVSEKDRIINVDEVTVLTGNKITPTAVINAEVEGER 408 Query: 419 KAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANY-NGRRFHG 477 K +A G GPVDA ++A+ + +++ ++ L A G DAL V + +G F Sbjct: 409 KVTSAIGVGPVDATFKAVTELLGRKIKITEFRLDAITGGSDALANVYVTVEDEDGETFTA 468 Query: 478 VGLATDIVESSAKAMVHVLNNIWRAAEVEK 507 DIV +S A++ +N + + +K Sbjct: 469 RSAGADIVMASFDAVIKAVNYLMLKKKRKK 498 >UniRef50_C0Z635 Probable 2-isopropylmalate synthase n=1 Tax=Brevibacillus brevis NBRC 100599 RepID=C0Z635_BREBN Length = 514 Score = 486 bits (1250), Expect = e-135, Method: Composition-based stats. Identities = 214/508 (42%), Positives = 309/508 (60%), Gaps = 3/508 (0%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M++++ IFDTTLRDGEQA ASLS ++K+ IA L +GVDV+E GFP+SSPGDF +VQ Sbjct: 1 MTKRIHIFDTTLRDGEQAPGASLSPEQKIVIAKHLADLGVDVIEPGFPISSPGDFMAVQR 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I+++V +C AR V++DID A + + AE R+H F+++S +H+ +LR + ++VI+ Sbjct: 61 ISQEVHGVEICGFARAVKEDIDAAVRATQAAERRRLHMFLSSSSIHLDFQLRKSREQVIK 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 A M+ + + D EFS DA RT L ++EAAI GAT INIPDTVGY +P E+ Sbjct: 121 IAREMIAYGKQFVDRFEFSPMDATRTGDEFLFEMIEAAIEEGATIINIPDTVGYALPEEY 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 + + + + V DK S H H+DLGLAV NSLAA+ AG QVE +NG+GERAGNCS Sbjct: 181 GAMFTRVMKNVRGSDKVEFSAHCHNDLGLAVANSLAAIRAGVTQVEVTVNGVGERAGNCS 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEE++MAI+ RK+ L+ T I + I+ TSQ VS+ + PI NK IVG AF H +GIH Sbjct: 241 LEELVMAIETRKEALDAETRIRPEHIYTTSQKVSRAMSFPIAFNKPIVGRNAFQHEAGIH 300 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 QDG+LK R YEIM PES+G+ + + L SGR A+KHR++E G + ++ ++ LY F Sbjct: 301 QDGLLKERSTYEIMDPESLGVPRNMIILGKHSGRHAIKHRVNEFGIQLTDEQMEALYVQF 360 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKL--ACGEEV 418 +LADK+ V D+ L L E F L V +G++ A+ + E Sbjct: 361 KELADKQKVVQDHQLLELVGH-TVNAVLEPFTLVNAQVLTGTSGHRMASCTIMNNVTGEE 419 Query: 419 KAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGV 478 +A + G GPV+A+ I + ++VE L + G+ A G+ + + NG F GV Sbjct: 420 QAYSGTGEGPVEALVAGIKQALPFDVEFTDMELYSLSSGEHATGEAIVTVSANGSHFKGV 479 Query: 479 GLATDIVESSAKAMVHVLNNIWRAAEVE 506 D++ + A+A + N R + + Sbjct: 480 AEHRDVLMAVAQAFMAASNQAVRDHQAK 507 >UniRef50_Q9LPR4 2-isopropylmalate synthase 1, chloroplastic n=39 Tax=cellular organisms RepID=LEU11_ARATH Length = 675 Score = 485 bits (1248), Expect = e-135, Method: Composition-based stats. Identities = 228/581 (39%), Positives = 317/581 (54%), Gaps = 74/581 (12%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 V +FDTTLRDGEQ+ A+L+ KEKL IA L ++GVD++E GFP +S DFE+V+TI Sbjct: 86 PNYVRVFDTTLRDGEQSPGATLTSKEKLDIARQLAKLGVDIIEAGFPAASKDDFEAVKTI 145 Query: 62 ARQVKNSR--------VCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRS 113 A V N+ +C L+RC +KDI+ A +++K A+ RIHTFIATS +H+ KL+ Sbjct: 146 AETVGNTVDENGYVPVICGLSRCNKKDIERAWDAVKYAKRPRIHTFIATSDIHLEYKLKK 205 Query: 114 TLDEVIERAIYMVKRARNYTD-DVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTV 172 T EVIE A MV+ AR+ DVEFS EDAGR+ L ++ I AGATT+NIPDTV Sbjct: 206 TKAEVIEIARSMVRFARSLGCEDVEFSPEDAGRSEREYLYEILGEVIKAGATTLNIPDTV 265 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G T+P EF +I+ L P I+ +IS H +DLGL+ N+L+ HAGARQ+E +NGI Sbjct: 266 GITLPSEFGQLITDLKANTPGIENVVISTHCQNDLGLSTANTLSGAHAGARQMEVTINGI 325 Query: 233 GERAGNCSLEEVIMAIKVRKD--ILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGS 290 GERAGN SLEEV+MAIK R D + + T I+ + I TS++V + M +KAIVG+ Sbjct: 326 GERAGNASLEEVVMAIKCRGDHVLGGLFTGIDTRHIVMTSKMVEEYTGMQTQPHKAIVGA 385 Query: 291 GAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQ---LNLTSRSGRAAVKHRMDE---- 343 AFAH SGIHQDG+LK++ YEI+ PE IGL + + L SGR A+K R+ E Sbjct: 386 NAFAHESGIHQDGMLKHKGTYEIICPEEIGLERSNDAGIVLGKLSGRHALKDRLTEVHSN 445 Query: 344 -------------------------MGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEAL 378 +GY+ + L ++ F +A++K +V D D+ AL Sbjct: 446 LTHTNTCIAIFVGDTNVLLSFVHFQLGYQLDDEQLSTIFWRFKTVAEQKKRVTDADIIAL 505 Query: 379 AFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKL-ACGEEVKAEAANGNGPVDAVYQAIN 437 Q E ++L + G+ ++TA VKL + + G GPVD+ Y+A++ Sbjct: 506 VSDEVFQPEA-VWKLLDIQITCGTLGLSTATVKLADADGKEHVACSIGTGPVDSAYKAVD 564 Query: 438 RITEY---------------NVELVKYSLTAKGHGKDALGQVDIVANYNG---------- 472 I + L++YS+ A G DA+ ++ + Sbjct: 565 LIVKVLFIPLRLSSTNNSPEPATLLEYSMNAVTEGIDAIATTRVLIRGSNKYSSTNAITG 624 Query: 473 ----RRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKEL 509 R F G G DIV SS KA V LN + E Sbjct: 625 EEVQRTFSGTGAGMDIVVSSVKAYVGALNKMMDFKENSATK 665 >UniRef50_A2C859 2-isopropylmalate synthase n=16 Tax=Bacteria RepID=LEU1_PROM3 Length = 540 Score = 484 bits (1247), Expect = e-135, Method: Composition-based stats. Identities = 245/515 (47%), Positives = 331/515 (64%), Gaps = 16/515 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 +V+IFDTTLRDGEQ+ ASL+++EKL IA L R+GVDV+E GFP +S GDF +VQ I Sbjct: 5 PGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDVIEAGFPFASQGDFSAVQRI 64 Query: 62 ARQV---KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEV 118 A+QV + +C LAR DI A+++ A RIHTFIATS +H+ KLR + EV Sbjct: 65 AQQVGGDEGPIICGLARASRADIKACADAVAPAPRRRIHTFIATSDIHLEHKLRKSRAEV 124 Query: 119 IERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 + MV AR+ DDVEFSCEDA R+ L V+EAAI AGA TINIPDTVG+T P Sbjct: 125 LAIVPEMVAYARSLVDDVEFSCEDAARSDPEFLYEVIEAAIAAGAGTINIPDTVGFTTPS 184 Query: 179 EFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGN 238 EF +I+G+ VPN+++AI+SVH H+DLGLAV N L AV +GARQ E +NGIGERAGN Sbjct: 185 EFGALIAGIDCHVPNMNEAILSVHGHNDLGLAVANFLEAVKSGARQFECTINGIGERAGN 244 Query: 239 CSLEEVIMAIKVRK-----------DILNVHTAINHQEIWRTSQLVSQICNMPIPANKAI 287 +LEE++MA+ VR+ D TA+ +EI +TS+LVS + M + NKAI Sbjct: 245 AALEELVMALYVRRRYFNPFFGRESDSPTPLTAVRTEEITKTSRLVSNLTGMVVQPNKAI 304 Query: 288 VGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK 347 VGS AFAH SGIHQDGVLKNR YEI+ ++GL +++L SGR+AV+ R++E+GY Sbjct: 305 VGSNAFAHESGIHQDGVLKNRLTYEIVDARTVGLTDNRISLGKLSGRSAVRARLEELGYD 364 Query: 348 ESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIAT 407 + +LD + F LAD+K + D DLEA+ + Q+ F+L V GS+ T Sbjct: 365 LTREDLDEAFARFKDLADRKRDITDRDLEAIVSE-QVQQPEARFQLRLVQVSCGSSLRPT 423 Query: 408 AAVKLAC-GEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDI 466 A V LA + + AA G GPVDAV +A+N + EL+++S+ + G DA+G+V I Sbjct: 424 ATVILAQEDGQEQTAAAVGTGPVDAVCRALNALAGEPNELIEFSVKSVTEGIDAMGEVTI 483 Query: 467 VANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWR 501 +G+ F G TD+V ++A+A V+ LN + Sbjct: 484 RLRRDGQLFSGHSADTDVVVAAAQAFVNALNRLVA 518 >UniRef50_UPI0001C31767 2-isopropylmalate synthase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31767 Length = 528 Score = 480 bits (1235), Expect = e-134, Method: Composition-based stats. Identities = 238/505 (47%), Positives = 320/505 (63%), Gaps = 2/505 (0%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 QV+IFDTTLRDGEQ+ SL+ EKL+IA L R+GVD++E GFP++SPGDFE+V+TI Sbjct: 8 PNQVLIFDTTLRDGEQSPGISLNTSEKLEIAQQLARLGVDIVEAGFPIASPGDFEAVETI 67 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 ARQV+ + LAR DID A +L+ A RIHTF++TS +HI ++RST ++VI Sbjct: 68 ARQVEGPVIAGLARIHVGDIDAAWNALRDASRPRIHTFVSTSDIHIEHQMRSTREDVIGL 127 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 V A+ Y DDVEFS DA R+ + A VV+ AI+ GATTINIPDTVGYTMP E+ Sbjct: 128 TRAGVAHAKQYVDDVEFSPMDATRSDVEFTAEVVQIAIDEGATTINIPDTVGYTMPHEYT 187 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 + LYE P + ++SVH HDDLGLAV NS A V AGARQVE A+NG+GERAGN SL Sbjct: 188 AFLGRLYELAPGLRDVVLSVHCHDDLGLAVANSFAGVLAGARQVECAINGLGERAGNASL 247 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EE++M ++ R+ + + T QEI R S+LVS++ + NKAIVG AFAH SGIHQ Sbjct: 248 EEIVMLLRTRQADIGLDTNAVSQEIARASRLVSRMTGYAVQPNKAIVGRNAFAHESGIHQ 307 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 DGVLKNRE +EIM SIGL+ L L SGR A++ + ++G L+ + F Sbjct: 308 DGVLKNRETFEIMDATSIGLDSNSLVLGKHSGRHALRDALAQLGIVVDGATLNTAFKRFK 367 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLAC-GEEVKA 420 ++ADKK QV DLEAL ++E P + L++F V++ S A V + Sbjct: 368 EIADKKKQVTAMDLEALVTDELREEIP-AYALEWFEVEASSRRPPHARVGVTLPDGSEAT 426 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 + G+GP+DAV+ AIN T +L + + A G+DALG+ +V +G G G+ Sbjct: 427 GSFTGDGPIDAVFHAINAATSVEAKLRDFRIDAVTSGQDALGETSVVLEVDGVSGAGQGV 486 Query: 481 ATDIVESSAKAMVHVLNNIWRAAEV 505 +TDI+E++ +A V L+N R V Sbjct: 487 STDIIEAAGRAYVRALSNAVRRRSV 511 >UniRef50_P58968 2-isopropylmalate synthase 2 n=19 Tax=Archaea RepID=LEU12_METMA Length = 516 Score = 474 bits (1219), Expect = e-132, Method: Composition-based stats. Identities = 186/509 (36%), Positives = 275/509 (54%), Gaps = 19/509 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 S++V +FDTTLRDGEQ SL+ +KL+IA L+++GVD++E GFP+SS GD ESV++I Sbjct: 17 SKKVTVFDTTLRDGEQTPGVSLTSTQKLEIAHQLDKLGVDIIEAGFPISSEGDKESVKSI 76 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 + ++ VC LAR ++KDID ES + +HTF+ TS + ++ + +EVI+ Sbjct: 77 SNAGLDTTVCGLARVLKKDIDACFES----DVGLVHTFVPTSDVQRIYTIKKSREEVIQL 132 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 A+ V+ +++ FS DA RT L V +A AG IN+PDTVG +P Sbjct: 133 AVEAVQYIKDHGLKCMFSAMDATRTDPEYLIEVFKAVQEAGCDIINVPDTVGVMVPSAMY 192 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 I G+ + I VH H+D GLAV NSL AV AGA QV+ +NGIGERAGN L Sbjct: 193 RQIKGIAAEIT----IPIDVHCHNDFGLAVANSLMAVEAGASQVQVTINGIGERAGNADL 248 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 + +M++ T I + + TS++V + +P N +VG AF+H SGIH Sbjct: 249 SQTVMSLTSIYGA---KTNIRTEYLVETSKMVENYTGIRLPPNTPVVGQNAFSHESGIHS 305 Query: 302 DGVLKNRENYEI--MTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 GVL+ + +E MTPE +G + ++ L +G+ AVK ++ G K ++ LD + Sbjct: 306 QGVLEKSDTFEPGIMTPEMVGHRR-RIVLGKHTGKHAVKQSLESAGIKTNDNQLDEIVIR 364 Query: 360 FLKLADKKGQVFDYDLEAL--AFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEE 417 ++A+K Q+ D DL A+ A +GK E E +L SV +G+ TA VK + Sbjct: 365 IKEIANKGKQITDADLYAVASAVLGKASSEEELIKLKEVSVMTGNILTPTAVVKADIEGK 424 Query: 418 VKAEAANGNGPVDAVYQAINRITEY--NVELVKYSLTAKGHGKDALGQVDIVANYN-GRR 474 A G GPVDA A+ I + L + + A G DAL V I GR Sbjct: 425 EIIAARTGVGPVDAALHAVRDILGESNHFRLQDFRIDAITGGADALADVYIGLENEKGRI 484 Query: 475 FHGVGLATDIVESSAKAMVHVLNNIWRAA 503 DIV +S +A+V+ +N +++ Sbjct: 485 VTARSANPDIVMASVEALVNAMNLLYKKE 513 >UniRef50_O26819 (R)-citramalate synthase n=20 Tax=Archaea RepID=CIMA_METTH Length = 496 Score = 472 bits (1215), Expect = e-131, Method: Composition-based stats. Identities = 187/505 (37%), Positives = 275/505 (54%), Gaps = 15/505 (2%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 QV + DTTLRDGEQ SL+ +EKL+IAL ++ +G D++E G ++S G+ E ++ I Sbjct: 2 QVRVLDTTLRDGEQTPGVSLTPEEKLRIALKIDALGADIIEAGSAITSEGEREGIRKITS 61 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 + + +C+ AR V +DID A + +H + TS +H+ KLR T +EV+E+A+ Sbjct: 62 EGLRAEICSFARAVREDIDAAI----SCDVDSVHLVVPTSDLHLEHKLRKTREEVLEQAV 117 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 + A ++ VE S ED+ R+ + L + I AGA I DTVG P Sbjct: 118 DCTEYAVDHGILVELSAEDSTRSDMDFLRTIFREGIEAGAERICACDTVGILTPERSYEF 177 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 GL E A +SVH H+D GLAV NSLA + AGA +V +NGIGERAGN +LEE Sbjct: 178 YRGLSEL-----GAPLSVHCHNDFGLAVANSLAGLRAGASEVHATINGIGERAGNAALEE 232 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 V++A+K D V T+IN + ++ TS++V+++ + + NKAIVG AFAH SGIH DG Sbjct: 233 VVVALKSLYD---VDTSINIEMLYETSRMVARMTGVYLQPNKAIVGENAFAHESGIHADG 289 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 VLK E YE +TPE +G + + G A++ R+DE+G K ++ L ++ L Sbjct: 290 VLKKAETYEPITPEMVGHGRG-FVMGKHIGTHALRKRLDELGMKVADDKLMEIFRRVKTL 348 Query: 364 ADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAA 423 D V D DL+A+A E + L ++ SG+ TA+VKL + EA Sbjct: 349 GDMGKCVTDVDLQAIAEDVLGVMEDKVVDLQEVTIVSGNRVTPTASVKLRVDDREVLEAG 408 Query: 424 NGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLA 481 G GPVDA AI + E ++ L +Y + A G DAL V I + R Sbjct: 409 TGVGPVDAAIVAIKKSLEDFADITLEEYHVDAITGGTDALIDVVIKLRHGDRIISARSTQ 468 Query: 482 TDIVESSAKAMVHVLNNIWRAAEVE 506 DI+ +S +A + +N + + E Sbjct: 469 PDIIMASVEAFLSGVNRLLANEKSE 493 >UniRef50_UPI0001C42034 citramalate synthase CimA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C42034 Length = 497 Score = 472 bits (1215), Expect = e-131, Method: Composition-based stats. Identities = 166/503 (33%), Positives = 275/503 (54%), Gaps = 16/503 (3%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 ++ + DTTLRDGEQ SL+ +KL+IA L+ +GV+ +E G ++S G+ E+++ I Sbjct: 2 KIEVLDTTLRDGEQTPGISLNTIKKLRIATKLDEIGVNSIEAGSAITSEGEREAIKAITS 61 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 Q N+ + + +R + KD+D E + ++ + TS +H+ KL+ T DE++E A+ Sbjct: 62 QGLNAEIVSFSRTLIKDVDYCLE----CDVDAVNIVVPTSDLHLQYKLKKTQDEMLEDAV 117 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 + + A+++ VE + ED+ RT I L ++ +A I+AGA I DT+G P + Sbjct: 118 KVTEYAKDHGVKVELAAEDSTRTDIQYLRKIFKATIDAGADRICPCDTLGILTPLKSFNF 177 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 + +S H H+D GLAV N+L+A+ GA + +NG+GERAGN +LEE Sbjct: 178 YKQFTDL-----GVPVSAHCHNDFGLAVANTLSAIDGGASRFHATINGLGERAGNAALEE 232 Query: 244 VIMAIKVRK----DILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 V++++ + T I +I+ TS+LVS++ N + NK IVG AFAH SGI Sbjct: 233 VVVSLYTLYKDESNERKYETDIKIDQIYSTSKLVSRLSNAYLAPNKPIVGENAFAHESGI 292 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 H DGV+KN YE + PE +G + + + G + +R++E+G + ++ L++++ Sbjct: 293 HADGVIKNSATYEPIMPELVGHRR-KFVIGKHVGTKGLNNRLEELGLEVNKKQLNDIFYK 351 Query: 360 FLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVK 419 L DK V D DLEA+A E+ + LD ++ SG+ TA++KL E Sbjct: 352 VKDLGDKGKTVTDTDLEAIAEHVLNIEQEKKINLDELTIVSGNKIRPTASIKLNIENEEV 411 Query: 420 AEAANGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHG 477 EA G GPVDA A+N+ + +++L +Y + A G DAL +V I + + Sbjct: 412 IEADVGIGPVDAAINAVNKGIKSFADIQLEEYHVDAVTGGTDALIEVIIKLSSGDKIISA 471 Query: 478 VGLATDIVESSAKAMVHVLNNIW 500 DI+ +S +A + +N + Sbjct: 472 RATEPDIINASVEAYIDGVNRLL 494 >UniRef50_A9KRN2 2-isopropylmalate synthase n=8 Tax=Bacteria RepID=A9KRN2_CLOPH Length = 505 Score = 470 bits (1210), Expect = e-131, Method: Composition-based stats. Identities = 208/502 (41%), Positives = 321/502 (63%), Gaps = 5/502 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ +FDTTLRDGEQ A L+ +EK+ IA LE++ VD ME GFP SS GDFE+V+ I+ Sbjct: 2 RKIYVFDTTLRDGEQVPGAKLNFEEKMYIAKQLEKLRVDYMEAGFPSSSQGDFEAVREIS 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 RQ+K+S V AL R V+ DID ESLK A IH + +S +HI K +++++ Sbjct: 62 RQIKDSSVVALGRAVKSDIDRMYESLKEAANPMIHIVLGSSNVHITKKFNKNPEDILQMG 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + V A+ YT VE+S EDA R+ + + R +EA + AGAT +NIPDTVG+ +P F G Sbjct: 122 VDAVTYAKRYTSQVEYSLEDASRSDLEYMWRTIEAVVKAGATCVNIPDTVGFAVPELFGG 181 Query: 183 IISGLYERVPNI-DKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 +I +Y+R+ N+ ++SVH H+D GLA N+LAAV GA +VE +NGIGERAGN SL Sbjct: 182 LIHQIYDRLQNVAPHVLLSVHCHNDSGLATANTLAAVRNGANKVECTINGIGERAGNTSL 241 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EEV+M IK+ + + +T INH I+ TS++VS+ + + NKA+VG AFAHSSGIHQ Sbjct: 242 EEVVMGIKLHPEYYDGYTDINHSAIYETSRIVSRTMGLDVQVNKALVGENAFAHSSGIHQ 301 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 DG+LK++E YEI P IG + + LT+RSG+ A ++ ++GY+ + L+ ++ FL Sbjct: 302 DGLLKSKEVYEIFEPSDIGAPPMDIVLTARSGKHAFEYISKKLGYEIAPEVLNEIHANFL 361 Query: 362 KLADKKGQVFDYDLEALAFIGKQQE---EPEHFRLDYFSVQSGSNDIATAAVKLACGEEV 418 K+AD+K +V+D D+ L ++ + E + + L+ F + + ++ +A VKL ++ Sbjct: 362 KIADEKKEVYDNDVIDLLDGDERVQKNGEKKLWMLEDFQINV-NMNLPSATVKLVRNKQE 420 Query: 419 KAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGV 478 + GNG + A+Y AI + + + L+ Y + G K++LG+V + YNG+ + G Sbjct: 421 AVVSEAGNGAISALYAAILKAVDMPIHLIDYRIQNIGAEKESLGKVVVQIQYNGKFYFGK 480 Query: 479 GLATDIVESSAKAMVHVLNNIW 500 + D++++SA A+V+ +N I Sbjct: 481 AIERDVMKASALALVNSVNKIV 502 >UniRef50_UPI0001C41E20 2-isopropylmalate synthase LeuA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41E20 Length = 511 Score = 469 bits (1207), Expect = e-130, Method: Composition-based stats. Identities = 182/507 (35%), Positives = 288/507 (56%), Gaps = 15/507 (2%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + ++ IFDTTLRDGEQA +L+V EK++IA L+ +GV+V+E+GFP S G+ ++ + Sbjct: 15 IPDEIKIFDTTLRDGEQAPGIALTVDEKIKIAQRLDELGVNVIEMGFPTVSSGERKAARE 74 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 + +S +C LAR V+KDID +L ++ H FI TSP+H KL+ + E++ Sbjct: 75 MVSLGFSSELCGLARVVQKDID----ALIDSDLSYAHLFIGTSPLHRDYKLKKSKTEILS 130 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 +++ MV+ A+++ VEFS EDA RT + L + +AGA IN+PDTVG +P Sbjct: 131 QSMEMVEYAKDHGLKVEFSAEDATRTELNYLIEFYKGVESAGADIINVPDTVGILVPSTT 190 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 +I L +++ IS+H H+D GLAV NSL + GA Q +NGIGERAGN S Sbjct: 191 RTLIRTLRKKI----NLPISLHFHNDFGLAVSNSLIGIEEGANQAHCTINGIGERAGNTS 246 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEE+++++K+ ++ +++ TS + I + +P K IVG AFAH SGIH Sbjct: 247 LEELVVSLKIAYGANLT---VDTTKLYDTSNFIGSITGIKMPPTKPIVGDNAFAHESGIH 303 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 DG+LKN YE + PE +G + ++ L +G AA+K +++E + ++ DN+Y+ Sbjct: 304 VDGILKNSSTYEPIAPEIVGHKR-RIALGKHTGHAAIKSKLEEFNIEVTQKQFDNIYNQV 362 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 L DK + D DL ++A E+ +L SV +G + ATA +KL+ ++ Sbjct: 363 KTLGDKGKCLTDDDLRSIAITEIGTSGKEYIKLLGLSVMTGESVSATATIKLSIDGKIME 422 Query: 421 EAANGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKDALGQVDIVANYN-GRRFHG 477 + G GPVDA A+ + + N+ L +Y L A G DAL + +V + + G + G Sbjct: 423 TSQIGVGPVDASVLALKTLVQDRVNISLDEYRLEAITGGTDALAETFVVISDDKGNKATG 482 Query: 478 VGLATDIVESSAKAMVHVLNNIWRAAE 504 D++ SS A+++ +N I E Sbjct: 483 RATREDVILSSVIAVINSINRILDIQE 509 >UniRef50_Q2S0M7 2-isopropylmalate synthase n=3 Tax=Bacteria RepID=Q2S0M7_SALRD Length = 546 Score = 467 bits (1203), Expect = e-130, Method: Composition-based stats. Identities = 233/534 (43%), Positives = 315/534 (58%), Gaps = 24/534 (4%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 MS + IFDTTLRDGEQA AS++V EK+ IA L + VDV+E GFP+SSP E+V Sbjct: 1 MSDSITIFDTTLRDGEQAPGASMTVPEKVHIAHKLADLNVDVIEAGFPISSPAQTEAVTR 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRS------- 113 IA +V CALAR E DID A E+L R+HTFIATS +HI K Sbjct: 61 IATEVDGPVTCALARTKEDDIDAAGEALADGTDTRLHTFIATSDVHIEAKFDKLGNTMAE 120 Query: 114 TLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVG 173 + +I+RA+ +++A YTD+VEFS EDAGRT L VV+AA AGATTINIPDT G Sbjct: 121 KREAIIQRAVRAIEQALTYTDNVEFSAEDAGRTDPEFLCEVVQAAAEAGATTINIPDTTG 180 Query: 174 YTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIG 233 Y P E+ ++ + + +P+ D +S H HDDLGLA N+LA + AGARQVE +NGIG Sbjct: 181 YCAPSEYTDLLETVVDCLPDPDAVTLSTHCHDDLGLATANTLAGIRAGARQVECTINGIG 240 Query: 234 ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAF 293 ERAGN +LEE++MA+ VR D +V ++ + + TSQ VS P+ NKAIVGS AF Sbjct: 241 ERAGNAALEEIVMALTVRADAFDVTADVHTEHLTPTSQTVSAATGFPVQPNKAIVGSNAF 300 Query: 294 AHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNL 353 +H +GIHQ GVL+ R YEIM+ +G + Q+ L SGR + +R++ MGY E + Sbjct: 301 SHEAGIHQHGVLEERTTYEIMSATDVGQDAEQIRLGRHSGRHGLFNRLEAMGYAVPEGHR 360 Query: 354 DNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEE----------------PEHFRLDYFS 397 D LYD FL LAD+K +VF+ DLE + +RLD FS Sbjct: 361 DALYDRFLDLADRKKEVFEEDLEQMMNDFGGDAVAAATGLPDNGVALNGGTPAYRLDQFS 420 Query: 398 VQSGSNDIATAAVKL-ACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGH 456 V S+D A +V+L + E A G GPVDA+Y+A++ + LV YS+ + Sbjct: 421 VHLSSDDEAKVSVRLQRDDGSAREEQATGEGPVDALYRALDHAVDAPHTLVDYSIRSISE 480 Query: 457 GKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQ 510 G DA G+V++ Y +F G TD++ +SA+A V LN + A E + ++ Sbjct: 481 GADAQGEVEVTIRYGENQFAGTARNTDVIRASAEAYVDALNRLVAAQEHAESVE 534 >UniRef50_Q1ARE2 2-isopropylmalate synthase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1ARE2_RUBXD Length = 510 Score = 466 bits (1199), Expect = e-129, Method: Composition-based stats. Identities = 224/485 (46%), Positives = 304/485 (62%), Gaps = 2/485 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ IFDTTLRDGEQ+ SLSV+EK++IA L R+ VDV+E GFP++S GDFE+V IA Sbjct: 2 RRIQIFDTTLRDGEQSPGISLSVEEKVEIAHQLARLKVDVIEAGFPITSEGDFEAVSRIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 +V+ + LAR ++DI+ A E+++ + RIHTF+ TS +HI ++RST +E++ A Sbjct: 62 SEVEGPVIAGLARIHQEDIERAWEAVRWSRRPRIHTFVGTSDLHIEHQMRSTREEILSGA 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 V+ A++ ++VEFS DA RT I LA VV AA+ AGA INI DTVGYT P EFA Sbjct: 122 AEAVRLAKSLCENVEFSPMDATRTDIGYLAEVVAAAVEAGADVINIADTVGYTTPAEFAA 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + L ERVP + + ++SVH HDDLG+AV NSLA V AGA QVE A+NGIGERAGN SLE Sbjct: 182 FLRELKERVPGLAERVLSVHCHDDLGMAVANSLAGVEAGATQVEVAVNGIGERAGNASLE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV+MA+ RKD V + +++ TS++VS + +P NKA+VG AF H SGIHQD Sbjct: 242 EVVMALVTRKDYYGVEVGVETRQLANTSRMVSNMTGYDVPPNKAVVGRNAFLHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 GVLK+R +EIM P IGL + L SGR A+K + ++GY L + F + Sbjct: 302 GVLKDRRTFEIMKPADIGLEGTNIFLGKHSGRHALKEALADLGYTLEGETLKRAFKRFKE 361 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKL-ACGEEVKAE 421 LAD K V DLEA+A E + F L+ F V + + + AAV++ Sbjct: 362 LADHKKTVTAADLEAIAADEVGSFEGK-FVLESFRVVAATGRQSRAAVRIAHADRGTFEA 420 Query: 422 AANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLA 481 A G GPVDAV++AI+ T L + + A GKDALG+V + + G G GL+ Sbjct: 421 EAEGEGPVDAVFRAIDSATGIKGRLTDFRIDAVTGGKDALGEVRVTVEFEGTECAGRGLS 480 Query: 482 TDIVE 486 D+VE Sbjct: 481 QDVVE 485 >UniRef50_A6VFV4 Isopropylmalate/citramalate/homocitrate synthase n=7 Tax=Methanococcales RepID=A6VFV4_METM7 Length = 492 Score = 466 bits (1199), Expect = e-129, Method: Composition-based stats. Identities = 172/503 (34%), Positives = 271/503 (53%), Gaps = 19/503 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V IFDTTLRDGEQ SLS EKL+IA+ L+ +GV+++E G ++S G+ E+++ +A Q Sbjct: 2 VNIFDTTLRDGEQTPGVSLSPSEKLEIAIKLDELGVNIIEAGSAITSKGEREAIKLVAEQ 61 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 N+ + + R + DID A +H + TS +H+ KLR T +E ++ A++ Sbjct: 62 KLNAEISSFVRALPVDIDAAL----SCNVDSVHLVVPTSDLHMEYKLRKTREENLKDAMH 117 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 V A+ + VE S EDA R+ + L + + A I + DTVG P + +I Sbjct: 118 AVDYAKEHGLIVELSAEDATRSDVEFLKELFKKGEELKADRICLCDTVGILTPVKSMELI 177 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + V IS+H H+D G+A N+L+A+ AGA Q +NGIGERAGN SLEEV Sbjct: 178 KTMKAAVT----IPISIHCHNDFGMATANTLSAISAGADQCHVTINGIGERAGNASLEEV 233 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 +M++K D + T I +++++ S++VS+ + +PANKA+VG AFAH +GIH DG+ Sbjct: 234 VMSLKSLYD---METNIQTEKLYKISRIVSKYMKLSVPANKALVGDNAFAHEAGIHVDGL 290 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 +K+ E YE + PE +G N+ ++ L SG+AA+K++++ M S + +Y Sbjct: 291 MKSTETYEPIGPEVVG-NRRKIILGKHSGKAALKYKLELMNIGLSHEQFEEVYSKIKAFG 349 Query: 365 DKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLA-----CGEEVK 419 D + D DL+ + + E LD +V SG+ A++ L ++ Sbjct: 350 DLGKYISDVDLKTVISQVQGVELERKVILDEITVMSGNKVSPLASINLKFANDCNIKDNI 409 Query: 420 AEAANGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHG 477 EAA G GPVDA A+ + ++EL YS+ A G DAL +V + Sbjct: 410 REAAYGLGPVDAAINAVKKALTGVADIELEDYSVRAMTGGTDALIEVVVHLRKGNEVVEV 469 Query: 478 VGLATDIVESSAKAMVHVLNNIW 500 D+V +S +AM+ +N + Sbjct: 470 RKAHGDVVMASVEAMMDGINLLI 492 >UniRef50_C6CVJ5 2-isopropylmalate synthase n=2 Tax=Bacillales RepID=C6CVJ5_PAESJ Length = 513 Score = 464 bits (1193), Expect = e-129, Method: Composition-based stats. Identities = 195/485 (40%), Positives = 301/485 (62%), Gaps = 3/485 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ IFDTTLRDGEQ+ AS+ + K+ IA L ++GVD++E GF +SSPG+F ++Q I+ Sbjct: 2 KKIQIFDTTLRDGEQSPGASIEPERKIIIARQLAKLGVDIIEPGFAISSPGEFAAIQQIS 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 R+++N +C AR V+ DID A ++ + A R+H FI++S +H++ ++R T EV++ A Sbjct: 62 RELQNVEICGFARAVKVDIDAAVKATQDAAKRRLHLFISSSDIHLSHQIRKTRSEVVQIA 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 M+ A+ + D+++F+ D+ R+ + +VEAAI +GAT IN+PDT+GY +P E Sbjct: 122 RDMISYAKQFVDEIQFAAMDSTRSDRDFVIELVEAAIESGATIINLPDTLGYALPNEMVD 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + + + ++ DK S H H+DLG+AV NSLAAV AGA QVE +NG+GERAGNCSLE Sbjct: 182 LFTSVRQQARGGDKVRYSTHNHNDLGMAVANSLAAVQAGATQVEVTVNGVGERAGNCSLE 241 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E+ M I+ RK L + T I EI+ TS +VS+ + PI NK IVG AF H SGIHQD Sbjct: 242 ELAMLIETRKSALEIETNIEQSEIYTTSHMVSRAMHYPIAYNKPIVGRNAFQHESGIHQD 301 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G+LK+R YEIM PE++G+++ + L SGR A+KHR+ E G ++ L+++YD F + Sbjct: 302 GLLKDRSTYEIMDPEAMGISRSMIILGRHSGRHAIKHRLSEYGIAVADNELNDVYDKFKQ 361 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLAC--GEEVKA 420 +AD+K V D +L +A + +P+ ++L V +GS A+V + ++ Sbjct: 362 VADEKKIVTDDELIRIAGEATET-QPDPYKLMDLQVLAGSQKSRIASVTIRDGEDGGERS 420 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 + G GP++AV I + + L + G+DA G+ + G RF G + Sbjct: 421 YSGMGEGPLEAVIHCIQQAIPVAAQFEDLELHSLSTGEDAHGEAVVSIVIEGERFRGTSI 480 Query: 481 ATDIV 485 DI+ Sbjct: 481 HKDII 485 >UniRef50_A8TGZ1 Isopropylmalate/citramalate/homocitrate synthase n=1 Tax=Methanococcus voltae A3 RepID=A8TGZ1_METVO Length = 574 Score = 460 bits (1184), Expect = e-128, Method: Composition-based stats. Identities = 177/527 (33%), Positives = 272/527 (51%), Gaps = 32/527 (6%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 IFDTTLRDGEQ + S +K KL+IA L+ +GV+ +E GFP++S G+FE+V+ I + Sbjct: 53 IFDTTLRDGEQTPEVSFPIKAKLEIASKLDELGVNTIEAGFPITSNGEFEAVKKIKQLDL 112 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 N+ +C L+RC KDID + + RIH FIATSP+H KL+ + ++++ + + Sbjct: 113 NATICGLSRCSNKDIDAVID----CDLDRIHLFIATSPLHREYKLKKSKEQILNKISESI 168 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 A+ + VEFS EDA RT + L RV + AI + I+IPDTVG P + +I Sbjct: 169 IYAKEHGLSVEFSAEDATRTELDYLIRVYKEAITSKVDYIDIPDTVGILTPKKMENLIKD 228 Query: 187 LYERV-------------------PNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEG 227 L + N+ ++SVH H+D GLAV NSL+A G Q+ Sbjct: 229 LKSGLETNKAINNSSTLTNQINIKSNMQMPVLSVHCHNDFGLAVANSLSAFEQGVSQIHC 288 Query: 228 AMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAI 287 +NGIGERAGN L E + ++K I I + + S+LV+ N+PI NK + Sbjct: 289 TVNGIGERAGNTDLAEFVSSLKFLCGIEPETLTIKTELLSDISKLVAHYTNIPIAPNKPL 348 Query: 288 VGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGY- 346 VG AFAH SGIH GV+ N YE ++P +G + +L L +G ++K ++ EMG Sbjct: 349 VGRNAFAHESGIHTHGVIANALTYEPISPFDVGNKR-RLVLGKHAGAHSIKLKLQEMGLN 407 Query: 347 ---KESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIG--KQQEEPEHFRLDYFSVQSG 401 S + + D L DK V D DL A+ K + L+ +V +G Sbjct: 408 VGKNLSTEQFEEIVDKIKALGDKGKLVLDADLRAIIKDVTSKVIKSKRVVNLEQLAVITG 467 Query: 402 SNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKD 459 N I TA+V + + + G GPVDA +A+ + +L++Y++ A G D Sbjct: 468 INVIPTASVAVNIAGKRYKASEMGVGPVDASLKALESVVGETVKAKLIEYTINAATGGSD 527 Query: 460 ALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVE 506 A+ V + N + + D+V +S +A++ +N + + + Sbjct: 528 AIADVVVKLENNKKIVTAKSTSEDVVHASVEAVIEGINRLLDESTIN 574 >UniRef50_C5SF21 Pyruvate carboxyltransferase n=1 Tax=Asticcacaulis excentricus CB 48 RepID=C5SF21_9CAUL Length = 527 Score = 447 bits (1151), Expect = e-124, Method: Composition-based stats. Identities = 202/521 (38%), Positives = 287/521 (55%), Gaps = 4/521 (0%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 +VI+FDTTLRDGEQA SL VK+KL +A L+ +GVDV+E GF SSPGD E+++TI Sbjct: 9 PNRVIVFDTTLRDGEQAPGFSLGVKDKLMLAHTLKDLGVDVIEAGFAASSPGDEEAIRTI 68 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 AR+V C+L+R +E DID AA +L A+ R H F+ATSP+H A KL+ T ++V+E Sbjct: 69 AREVVGPTFCSLSRALESDIDAAARALLPAKRKRCHIFLATSPIHRAAKLKKTREQVVEI 128 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 A V A D+VEFS EDA RT L V AA AGA T+NIPDTVGYT P E Sbjct: 129 AHKAVSYASTIFDEVEFSPEDAIRTEQDFLHEVCIAAAEAGARTLNIPDTVGYTTPKEIY 188 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 I S L + + + I+S H HDDLGL V N+LAA+ AGARQ+E +NGIGERAGN +L Sbjct: 189 QIFSDLKAALKDHPQVILSAHNHDDLGLGVANTLAALEAGARQIEVTINGIGERAGNAAL 248 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EEV+MA++ R ++ +HT IN + + S L+S+ + NKA+VG AFAH SGIHQ Sbjct: 249 EEVVMALRTRPELFKLHTGINTPLLSKASHLLSRATGTIVMRNKAVVGRNAFAHESGIHQ 308 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 G+L + YEIM PE +G + L L SGR A+ + +G+ E +L +L+ AF Sbjct: 309 HGMLTDARTYEIMRPEDVGAEKSNLVLGKHSGRHAIAKQAAALGFDLDELSLGDLFAAFK 368 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAE 421 + AD+ G++ + E ++ + + + + RL S + + + E Sbjct: 369 RRADEIGEI--DEFELMSLLTRDNADKDDARLFKVSSEVTKDFVTITLDLFRDNGEPLKV 426 Query: 422 AANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLA 481 A G +A ++A+ + + + G D +I G + G G Sbjct: 427 TATGLNAFEAGFRALVDAYQIEARVNDCEIIQSGFTFDGGAFAEISLQIKGEAYRGRGRG 486 Query: 482 TDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKET 522 D V + +AM + + ++E ET Sbjct: 487 PDPVWAGLRAMCDAFEKYVFLHDRKT--HASNLNSEKQHET 525 >UniRef50_Q0AT07 2-isopropylmalate synthase n=3 Tax=Alphaproteobacteria RepID=Q0AT07_MARMM Length = 529 Score = 445 bits (1145), Expect = e-123, Method: Composition-based stats. Identities = 203/517 (39%), Positives = 299/517 (57%), Gaps = 7/517 (1%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 ++ IFDTTLRDGEQA S++ EKL+IA LE M VD +E GF +SPGD E+++ I Sbjct: 14 PDRLRIFDTTLRDGEQAPGFSMNPAEKLEIARLLEAMRVDTIEAGFAAASPGDSEAIRLI 73 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 A +++NS +C+LAR E DID AA++L+ A R+H F+ATSP+H KLR + EV++ Sbjct: 74 ASEIRNSTLCSLARATEGDIDAAAKALEPAHRKRLHIFLATSPIHREAKLRMSRREVLQT 133 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 +K A D++EFS EDA RT L + A GA +N+PDTVGY+ P E Sbjct: 134 IERCLKHAAGTFDEIEFSAEDALRTEPDFLVEAMSCAAVNGADVLNVPDTVGYSEPDEIR 193 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 + L V D I S H H+DLGLAV NSLAAV GARQVE A+NGIGERAGNCSL Sbjct: 194 AVFERLAAHVERPDHVIFSAHCHNDLGLAVSNSLAAVKGGARQVECAINGIGERAGNCSL 253 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EE++MA++VR DI + ++ +IW SQ ++++ + NKAIVG AFAH +GIHQ Sbjct: 254 EEIVMALQVRADIFPAISHVDATKIWSASQRLARVTGSAVAPNKAIVGKNAFAHEAGIHQ 313 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 G++ +R YEIMTPES+G L L SG+ A+ R+ ++GY+ L+ ++ F Sbjct: 314 HGMISDRRTYEIMTPESVGAPGSALVLGKHSGKHALVQRLAKLGYQPDPDKLNQVFKDFK 373 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA- 420 LAD+ G+V D DL A+ +G A V+L + + Sbjct: 374 HLADELGEVNDADLVAMMEGFSASGSRWTVLRTELRTTAGRQPKQFARVELEHPDRGRVS 433 Query: 421 EAANGNGPVDAVYQAINRITEYNVEL--VKYSLTAKGHGKDALGQVDIVANYNGRRFHGV 478 + A+G+GP+ A + A+ RIT + + ++ + + G++ + DI + +G F G Sbjct: 434 DIASGDGPIAAAFAAVQRITGTDATVTALETRMRSTATGREFVA--DISIDIDGTIFSGR 491 Query: 479 GLATDIVESSAKAMVHVLNN--IWRAAEVEKELQRKA 513 DIV ++ +++ L+ + A++ ++ A Sbjct: 492 ARGPDIVTAAIDSLLFTLDRGEAYGRADLTQQQPAAA 528 >UniRef50_A8V4T9 2-isopropylmalate synthase (Fragment) n=2 Tax=cellular organisms RepID=A8V4T9_9AQUI Length = 432 Score = 443 bits (1140), Expect = e-123, Method: Composition-based stats. Identities = 228/420 (54%), Positives = 295/420 (70%), Gaps = 3/420 (0%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++IIFDTTLRDGEQA S++V+EK+++A LE++GVDV+E GF +S GDFE+V +A Sbjct: 12 RKLIIFDTTLRDGEQAPGFSMTVEEKVRMAKQLEKLGVDVIEAGFAAASKGDFEAVNEVA 71 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 ++VKNS VC+LAR + DI+ A E+L AE RIHTFIATSP+H+ KLR T ++V+ERA Sbjct: 72 KEVKNSTVCSLARALHSDIERAGEALAPAERKRIHTFIATSPIHMEYKLRMTPEQVLERA 131 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + V+ ARN+TDDVEFS EDA R+ L R+ EA I AGA TIN+PDTVGY +P EF Sbjct: 132 VDAVQFARNFTDDVEFSAEDAVRSEREFLYRIFEAVIAAGAKTINVPDTVGYAVPEEFGQ 191 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 +IS + VPNIDKA+ISVH H+DLGLAV NSL AV GA QV +NGIGERAGN +LE Sbjct: 192 LISDILNNVPNIDKAVISVHCHNDLGLAVANSLTAVKNGAGQVHSTINGIGERAGNAALE 251 Query: 243 EVIMAIKVRKDIL-NVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EV+MAIKVRKD +V+T IN +EI+RTS+L+ ++ + NKAIVG AFAH +GIHQ Sbjct: 252 EVVMAIKVRKDYFKDVYTDINTKEIYRTSRLLCRLTGSFVQPNKAIVGDNAFAHEAGIHQ 311 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGY-KESEYNLDNLYDAF 360 G+L RE YEIM E +G+ ++ L SGR A K R++E+GY SE +D L+ F Sbjct: 312 HGLLAKRETYEIMKAEDVGVPSSKIVLGKHSGRHAFKTRLEELGYKNLSEEEIDKLFAKF 371 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA 420 +LADKK +VFD D+EAL F + E +L F + SG+ I TA VKL E Sbjct: 372 KELADKKKEVFDEDIEALLFDELFKSYEE-VKLLQFQIVSGNKAIPTATVKLKIDGEEIV 430 >UniRef50_D2RVT7 Pyruvate carboxyltransferase n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT7_9EURY Length = 508 Score = 437 bits (1123), Expect = e-121, Method: Composition-based stats. Identities = 168/506 (33%), Positives = 260/506 (51%), Gaps = 18/506 (3%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + V + DTTLRDGEQA SL+ EK+ IA +LE+ GV V+E G + G+ +++ + Sbjct: 13 RTVRLLDTTLRDGEQAPGVSLTPDEKVDIARSLEQAGVSVIEAGSACTGAGERQAISRVT 72 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 ++RV + R +E DID+A + + +H + S HI K+ ++ ++ +E+ Sbjct: 73 DLELDARVTSFCRGMESDIDLALD----CDVDGVHIVVPASDRHIEDKVGTSHEDNLEKT 128 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 +V A+++ VE ED R + L ++ A++AGA I DTVG+T P A Sbjct: 129 AELVAYAKDHDLWVEVIGEDGSRADLDYLEELMATAVDAGADRICFADTVGHTGPERTAE 188 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + L D +S HTHDDLGL V N+LAAV AGA V +NG+GERAGN +LE Sbjct: 189 AVGRL------ADVGPVSAHTHDDLGLGVANALAAVSAGADLVHCTVNGLGERAGNVALE 242 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV +A+ D+ + E++ +Q VS+ + +P NKA++G AF H SGIH D Sbjct: 243 EVAIALSHVYDVET----LELTELYDLAQTVSRATGIQLPPNKAVIGENAFTHESGIHTD 298 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G LK+ + YE PE++G + +L L +GRA V ++E G + + + + Sbjct: 299 GTLKDDKMYEPYAPETVGRER-RLALGKHTGRAGVTATLEEHGVEADSDEVAEIATRVTE 357 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEA 422 L D+ +V D DL A+A + L + SG + TA+V+L E + + Sbjct: 358 LGDRGRRVTDADLLAIAEDVTGDDRERVVELLDLNATSG-GAVPTASVRLEVDGEERVAS 416 Query: 423 ANGNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL 480 G+GPVDA A+ + EL Y + A G DA+ V++ N R Sbjct: 417 GTGSGPVDAAVSAVREALGSMADAELDSYHVDAVTGGTDAVVTVEVTMMRNDRSVTVARS 476 Query: 481 ATDIVESSAKAMVHVLNNIWRAAEVE 506 DI +S +AMV L+ + A + Sbjct: 477 EADITRASVEAMVDALDRLLAADQQP 502 >UniRef50_Q18KM5 2-isopropylmalate synthase n=9 Tax=Euryarchaeota RepID=Q18KM5_HALWD Length = 531 Score = 430 bits (1106), Expect = e-119, Method: Composition-based stats. Identities = 171/498 (34%), Positives = 258/498 (51%), Gaps = 18/498 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V + DTTLRDGEQA SL EK +IA L+R G++ +E G + G+ E+++ + Sbjct: 23 VQLLDTTLRDGEQAPGISLDPDEKAEIARELDRSGIEFIEAGSACTGEGERETIRQVTGL 82 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 ++ V + AR V+ DI++A + + + S HI TK+ ST EV+ Sbjct: 83 DLDATVTSFARGVKSDIELAVD----CGVDGVTIVVPASDQHIETKVGSTRSEVVTTTAE 138 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 +V+ A+++ VE ED R I L R++ A++AGA DTVG+ P + Sbjct: 139 LVEYAKDHDLWVEVIGEDGSRADIEFLERLMREALDAGADRSCYADTVGHANPETTYEYV 198 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 S L P +S HTHDDLGLA+ N ++ AGA V G +NGIGERAGN +LEEV Sbjct: 199 SRLAALGP------VSTHTHDDLGLAMTNVWVSLAAGADLVHGTVNGIGERAGNVALEEV 252 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 +A+ DI +++ +Q VSQ N+P+P NKA++G AF H SGIH DG Sbjct: 253 AIALAHGYDIETAT----LDQLYSLAQTVSQATNIPLPPNKAVIGENAFTHESGIHTDGT 308 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 LK++ YE +P S+G + +L L +GRA V+ +DE SE + + D +L Sbjct: 309 LKDKTMYEPYSPSSVGRER-RLVLGKHAGRAGVQAALDEHRIDVSEDEVTAIVDRVKELG 367 Query: 365 DKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAAN 424 D+ +V D DL +A + +E H L + SG TA+++L GE + + Sbjct: 368 DRDKRVTDADLLTIAEEVQGRERDRHVELLDLTAASG-GGTPTASIRLRVGENERVASGT 426 Query: 425 GNGPVDAVYQAINRITE--YNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLAT 482 G+GPVDA +A+ + +L Y + A G DA+ V++ + R + Sbjct: 427 GSGPVDAAVEAVRAALGTDADAQLDSYHVDAITGGTDAVVTVEVEMSRGDRTVSVATSDS 486 Query: 483 DIVESSAKAMVHVLNNIW 500 DI S +AMV L+ + Sbjct: 487 DITRCSVEAMVEALDRLL 504 >UniRef50_O66682 Uncharacterized AIPM/Hcit synthase family transferase aq_356 n=44 Tax=Bacteria RepID=LY41_AQUAE Length = 528 Score = 429 bits (1103), Expect = e-118, Method: Composition-based stats. Identities = 158/531 (29%), Positives = 269/531 (50%), Gaps = 31/531 (5%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+++V I+DTTLRDG Q S S+++K++IA L+ G+ +E G+P ++P D Q Sbjct: 1 MAEKVYIYDTTLRDGSQMEGVSFSLEDKIRIAEKLDDFGIHYIEGGWPYANPKDNLFFQK 60 Query: 61 IARQV-KNSRVCALARCVEKDIDVA----AESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + KN+++ A + V+ ESL AE + F + +H+ L++TL Sbjct: 61 AKKMNFKNAKLTAFGSTRRPNKKVSEDPQVESLIKAETPVVTIFGKSWDLHVTDALKTTL 120 Query: 116 DEVIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTV 172 +E + V+ + Y D+V F E D ++ +V+EAA+ GA + + DT Sbjct: 121 EENLNMIYETVEYLKRYVDEVIFDAEHFFDGYKSNPEYALQVLEAALKGGADWVVLCDTN 180 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G T+P E I + ER + A + +H H+D AV NSL AV AGARQV G +NGI Sbjct: 181 GGTLPHEIYEITKKVKERFKD---ANVGIHAHNDSETAVANSLMAVLAGARQVHGTINGI 237 Query: 233 GERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 GER GN +L +I ++++ V N +++ + V++I NMP+P N VG A Sbjct: 238 GERTGNANLCSIIPNLQLKLGFD-VIPQENLKKLTELANFVAEIINMPLPRNMPYVGESA 296 Query: 293 FAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEY- 351 FAH G+H VLKN + YE + PE +G + ++ ++ +GR+ + H++ E G + Sbjct: 297 FAHKGGVHASAVLKNAKTYEHINPELVGNKR-KITVSDLAGRSNLVHKLKEFGIEIDPKS 355 Query: 352 -NLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQE--EPEHFRLDYFSV-----QSGSN 403 L L D +L +K+G F+ +L + K+ ++F D + V + S Sbjct: 356 PELKKLIDKIKEL-EKEGYHFEAAEASLELLIKRHFGLVKDYFDFDAYRVLIAKRRDDSL 414 Query: 404 DIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEY------NVELVKYSLTAKGH- 456 + A V+L+ + A+ GNGP+ A+ +A+ + E ++L+ Y + Sbjct: 415 PTSEATVRLSVEGVEEHTASLGNGPISALDRALRKALEEFYPNLKELQLIDYKVRIINES 474 Query: 457 -GKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVE 506 G A +V I + R++ VG++ +++E+S A+ + E E Sbjct: 475 AGTSAKVRVLIESTDGKRKWGTVGVSENVIEASWIALRDSIVYKLMKDEEE 525 >UniRef50_Q2RGA1 2-isopropylmalate synthase n=5 Tax=Clostridia RepID=Q2RGA1_MOOTA Length = 533 Score = 425 bits (1093), Expect = e-117, Method: Composition-based stats. Identities = 147/537 (27%), Positives = 266/537 (49%), Gaps = 29/537 (5%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+++++I+DTTLRDG Q SLSV++KL+IA L+R+GVD +E G+P ++P D E Sbjct: 1 MAEKILIYDTTLRDGSQGEGISLSVEDKLKIASRLDRLGVDYIEGGWPWANPKDMEFFLR 60 Query: 61 IARQV-KNSRVCALARCVEKDIDVAAES----LKVAEAFRIHTFIATSPMHIATKLRSTL 115 + + +R+ A R + A ++ +K A F + +H+ L +TL Sbjct: 61 AREVIWRQARLVAFGRTRKPGQAAAEDANLLAIKRAGVKVATIFGKSWDLHVTAALGTTL 120 Query: 116 DEVIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTV 172 E + V + +V + E D + ++AA AGA+ I + DT Sbjct: 121 AENLAMIGDSVAFLVDQGLEVIYDAEHFFDGFKANPDYALETLKAAAKAGASWIVLCDTN 180 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G +P+E ++ + + + + + +H H+D LAV N+LAAV AG RQV+G +NG Sbjct: 181 GGCLPWEIEEAVARVRQEI----QVPVGIHAHNDGDLAVANTLAAVTAGCRQVQGTINGF 236 Query: 233 GERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 GER GN L V+ ++++ + + S+ VS+I N+ N+ VG A Sbjct: 237 GERCGNADLCSVMPNLELKMGYQCLPPG-QLAFLTEVSRYVSEIANVVPAGNQPFVGYSA 295 Query: 293 FAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYN 352 FAH GIH VLK + YE + P+ +G + ++ ++ ++G + ++ + +EMG + + Sbjct: 296 FAHKGGIHVSAVLKAPDTYEHIRPQQVGNER-RVLMSDQAGASNLRCKAEEMGLELNPER 354 Query: 353 LDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQ--EEPEHFRLDYFSV----QSGSNDIA 406 + + +L +++G F+ +L ++ E + F ++Y ++G I+ Sbjct: 355 ERGIIEGIKEL-ERQGYQFEGADASLELFLRKTTGEYRQQFEVEYVKALVEKRAGQEAIS 413 Query: 407 TAAVKLACGEEVKAEAANGNGPVDAVYQAINRITE------YNVELVKYSLTAKGH--GK 458 A VKL G++V AA GNGPV+A+ A+ + E ++ L Y + Sbjct: 414 EAIVKLRVGDQVVHTAAEGNGPVNAMDNALRKALEEVFPAIRHMRLTDYKVRVLDEKDAT 473 Query: 459 DALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQH 515 A +V I + ++ VG++T+I+E+S +A++ + + E + A Sbjct: 474 SARVRVLIESRDGSNSWNTVGVSTNIIEASWEALLDSMEYALLKQQQELNKRAAAPC 530 >UniRef50_D2RHQ3 Isopropylmalate/citramalate/homocitratesynthase n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RHQ3_ARCPR Length = 529 Score = 422 bits (1086), Expect = e-116, Method: Composition-based stats. Identities = 164/540 (30%), Positives = 260/540 (48%), Gaps = 56/540 (10%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + I DTTLRDGEQ SL+V++KL IA AL+ +GVDV+E G ++ +F +V+ IA Sbjct: 2 LRILDTTLRDGEQTPGVSLTVEQKLIIAQALDDLGVDVIEAGTAIAGEEEFRAVKEIANA 61 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKL-RSTLDEVIERAI 123 + +C+ AR E DID ++ A+A + +S +HI TK + D++IE ++ Sbjct: 62 GLKAEICSFARIKEIDID----AVANADADSVFMVAPSSDIHIKTKFPNKSGDDIIEMSV 117 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 V+ A+ VEF ED+ R + + + A ++AGA + DTVG P + I Sbjct: 118 KAVEYAKERGLIVEFGAEDSSRANLNFVKALFRAVLDAGADRLTFTDTVGVLTPEKAECI 177 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 + L I+ H H+D GLA N++ AV GAR++ +NG+GERAGN LEE Sbjct: 178 MRELTSEF----NVPIAFHGHNDFGLATANTIFAVKGGAREIHVTINGLGERAGNAPLEE 233 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 V++A++ + T I ++I+ TS+LV + PI NK IVG AF H SGIH Sbjct: 234 VVLALETFYG---IKTKIRKEKIYDTSKLVEALTRFPIALNKPIVGYNAFMHESGIHTSA 290 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 +L+N + YE ++PE IG + + SG+A++ ++E+GY+ S + + ++ Sbjct: 291 LLRNAKAYEPISPEMIGRKRA-IVHGKHSGKASIMRLIEELGYEASGEQVKEIMKRIKEM 349 Query: 364 ADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSG-SNDIATAAVKLACGEEVKAEA 422 + +V DL + + ++ + L +V G S A++K+ E Sbjct: 350 EGRGQKVMGSDLIKIIEEVLKVKKGKKIVLKGLNVVCGKSGTSPHASIKICLNGEDIEAT 409 Query: 423 ANGNGPVDAVYQAINRITE--------------YNVELVKYSLTA--------------- 453 A G GP DA +A+ + NV+LV Y A Sbjct: 410 ALGKGPFDASIRALKNALKEYANKSGDKAVGELVNVKLVNYKANAIIDDKVIEYIEKLVE 469 Query: 454 -------------KGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIW 500 G DA V I + R +G +TDI+ +S +A + LN + Sbjct: 470 KNPKLSGLVEKIRIMTGTDAPVDVIIQLEKDDRVVTAIGRSTDIIHASVEAYIECLNKLI 529 >UniRef50_Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic n=19 Tax=Brassicaceae RepID=MAM3_ARATH Length = 503 Score = 407 bits (1046), Expect = e-112, Method: Composition-based stats. Identities = 167/406 (41%), Positives = 258/406 (63%), Gaps = 17/406 (4%) Query: 1 MSQQ--VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESV 58 + + V + DTTLRDGEQ+ A+L+ +KL+IA L ++ VD+MEVGFPVSS +FE++ Sbjct: 79 LPHKNYVRVLDTTLRDGEQSPGAALTPPQKLEIARQLAKLRVDIMEVGFPVSSEEEFEAI 138 Query: 59 QTIARQVKN---------SRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIAT 109 +TIA+ V N +C +ARC ++DI+ E+LK A+ R+ F +TS +H+ Sbjct: 139 KTIAKTVGNEVDEETGYVPVICGIARCKKRDIEATWEALKYAKRPRVMLFTSTSEIHMKY 198 Query: 110 KLRSTLDEVIERAIYMVKRARNYTD-DVEFSCEDAGRTPIADLARVVEAAINAGATTINI 168 KL+ T +EVIE A+ VK A++ D++F CED GRT + +++ +I AGATT+ Sbjct: 199 KLKKTKEEVIEMAVNSVKYAKSLGFKDIQFGCEDGGRTEKDFICKILGESIKAGATTVGF 258 Query: 169 PDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGA 228 DTVG MP EF +++ + E P D + ++H H+DLG+A N+++ + AGARQVE Sbjct: 259 ADTVGINMPQEFGELVAYVIENTPGADDIVFAIHCHNDLGVATANTISGICAGARQVEVT 318 Query: 229 MNGIGERAGNCSLEEVIMAIKVRKD--ILNVHTAINHQEIWRTSQLVSQICNMPIPANKA 286 +NGIGER+GN LEEV+MA+K R + + V+T I+ ++I TS++V + M + +K Sbjct: 319 INGIGERSGNAPLEEVVMALKCRGESLMDGVYTKIDSRQIMATSKMVQEHTGMYVQPHKP 378 Query: 287 IVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQ---LNLTSRSGRAAVKHRMDE 343 IVG F H SGIHQDG+LKNR YEI++PE +G+ + + + L SGR AVK R+ E Sbjct: 379 IVGDNCFVHESGIHQDGILKNRSTYEILSPEDVGIVKSENSGIVLGKLSGRHAVKDRLKE 438 Query: 344 MGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPE 389 +GY+ S+ ++++ + +L K ++ D DL+AL G + + Sbjct: 439 LGYEISDEKFNDIFSRYRELTKDKKRITDADLKALVVNGAEISSEK 484 >UniRef50_C6PDK4 Pyruvate carboxyltransferase n=1 Tax=Thermoanaerobacterium thermosaccharolyticum DSM 571 RepID=C6PDK4_CLOTS Length = 397 Score = 406 bits (1043), Expect = e-111, Method: Composition-based stats. Identities = 173/386 (44%), Positives = 246/386 (63%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 ++VI+FDTTLRDGEQ + K +IA L +GVDV+E GFP +S G+FE+V+ IA Sbjct: 4 RKVIVFDTTLRDGEQTPGVNFDKDSKYRIAKQLVSLGVDVIEAGFPAASNGNFEAVKHIA 63 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 + + V L+RCV+ DID E+LK A+ RIH FIATS +H+ KL+ + DE ++ A Sbjct: 64 ENIDDVVVAGLSRCVKSDIDKTYEALKNAKKSRIHLFIATSDIHLKYKLKISRDEALKMA 123 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + VK A D+++FS EDA RT L ++ ++AGA INIPDTVGY +P EF Sbjct: 124 VDSVKYASGKFDEIQFSAEDASRTDWDFLVKIFNEVVDAGAKIINIPDTVGYAVPKEFEK 183 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 ++ + + + + D ISVH H+DLG+AV NSL+A+ GA QVE + GIGERAGN SLE Sbjct: 184 LVEYVKKHIHDKDNVTISVHCHNDLGMAVVNSLSALENGADQVEVTVCGIGERAGNASLE 243 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EVIMAI RKD N+ +IN +EI+ T +LVS++ + + NKAIVGS AF H++GIHQ Sbjct: 244 EVIMAINTRKDYFNLLHSINTREIFSTCKLVSELSGIDLQPNKAIVGSNAFRHTAGIHQH 303 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 GV+ N+ YEIM PE IG+ +++ SGR A + ++ MGY+ S ++ + F Sbjct: 304 GVINNKATYEIMRPEDIGITTDHISMGKLSGRNAFELKLKNMGYELSRDEMNLAFKKFKD 363 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEP 388 +AD K V D +++A+ + Sbjct: 364 VADNKKIVNDNEIKAIVDDVISNSKS 389 >UniRef50_A8AB61 2-isopropylmalate synthase n=25 Tax=Archaea RepID=LEU1_IGNH4 Length = 399 Score = 404 bits (1038), Expect = e-111, Method: Composition-based stats. Identities = 156/388 (40%), Positives = 227/388 (58%), Gaps = 11/388 (2%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + ++V IFDTTLRDGEQ S + ++KL IA L ++GV +E GFP S G+FE+V+ Sbjct: 16 LPKEVRIFDTTLRDGEQTPGISFTKEQKLMIARQLAKLGVASIEAGFPAVSQGEFEAVKA 75 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 IAR+ + ALAR ++DID A + A+ IH FIA S +H+ KLR T +E + Sbjct: 76 IAREGLGPEIVALARANKRDIDKALD----ADVDAIHVFIAASDIHLKYKLRMTREEALR 131 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 RA+ V+ A+++ VEFS ED R + L +VEA ++AGA ++IPDTVG P Sbjct: 132 RAVEAVEYAKSHGVTVEFSPEDGTRADLNYLYTMVEAVVDAGADRVDIPDTVGVMTPTRM 191 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 +I + +P I+SVH H+D GLAV NS+A + AGARQ +NGIGERAGN + Sbjct: 192 KYLIKFI---LPAAKGRIVSVHCHNDFGLAVANSIAGIEAGARQAHVTVNGIGERAGNAA 248 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV+ A++ + V T +N + ++ TS LVS+I +PIP NK IVG F+H SGIH Sbjct: 249 LEEVVAALEFLLN---VRTGVNTKLLYETSLLVSKITGIPIPPNKPIVGENVFSHESGIH 305 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 GV+ N YE + PE +G + ++ L SGR V++ + +GY + + D Sbjct: 306 VHGVINNPFTYEPIQPEMVG-QRRRIVLGKHSGRHGVEYALKTLGYPTDPDVVLRVLDEV 364 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEP 388 +L D +V + L + ++ E Sbjct: 365 KRLGDMGIRVTEDKLREIVEKVLEERER 392 >UniRef50_C3NF24 2-isopropylmalate synthase/homocitrate synthase family protein n=19 Tax=Thermoprotei RepID=C3NF24_SULIN Length = 553 Score = 402 bits (1033), Expect = e-110, Method: Composition-based stats. Identities = 139/523 (26%), Positives = 249/523 (47%), Gaps = 30/523 (5%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + V + DTTLRDG Q S ++ +K++IAL L+ +GV+ +E G+P S+P D E + I Sbjct: 31 KSVEVLDTTLRDGSQGANISFTLNDKIKIALLLDELGVEYIEGGWPGSNPKDEEFFKEIK 90 Query: 63 R-QVKNSRVCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + ++ +R+ A KD+ D++ S+ A+ F + +H L+ T + Sbjct: 91 KYKLSKARIAAFGSTKRKDVSVKEDISLNSIIKADVDFAVIFGKSWSLHATEVLKVTKQD 150 Query: 118 VIERAIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTVGY 174 ++ + R++ V F E + VV+ A +AGA I + DT G Sbjct: 151 NLDIIYDSINYLRSHGLKVIFDAEHFYQGFKEDPKYALEVVKTAESAGADVIALADTNGG 210 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 T PFE I + E + + +H H+D+G AV NSL A+ AGAR V+G +NGIGE Sbjct: 211 TPPFEVYEITKKVREVLH----VKLGIHAHNDIGCAVANSLMAIKAGARHVQGTINGIGE 266 Query: 235 RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFA 294 R GN L ++I + ++ + + +++ S++V +I +P + VG AFA Sbjct: 267 RTGNADLIQIIPTLVLKMGFNVLKGRDSLRKLREVSRIVYEILGLPPNPYQPYVGDNAFA 326 Query: 295 HSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKES--EYN 352 H +G+H D V+K YE + P +G ++ + ++ SG A + + +G + Sbjct: 327 HKAGVHVDAVMKVPRAYEHVDPLLVGNDR-KFVISELSGTANLVSYLQGIGIVVDKKDER 385 Query: 353 LDNLYDAFLKLADKKGQVFD--YDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAV 410 L + +L + KG FD L + + + L+Y+ V + +N ++ V Sbjct: 386 LKKALNKIKEL-ETKGYSFDVGPASAILITLKELNMYTNYINLEYWKVINENNGLSIGIV 444 Query: 411 KLACGEEVKAEAANGNGPVDAVYQAINRITEY------NVELVKYSLTAKGH--GKDALG 462 K+ + E A G GPV+A+ +A+ + V+L+ Y + +++ Sbjct: 445 KV----NSQLEVAEGVGPVNAIDRALRMALQRVYPEISEVKLIDYRVILPSEVKNTESVV 500 Query: 463 QVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 +V I N + G++ +VE+S A+V L+ + + Sbjct: 501 RVTIEFTDNKMNWRTEGVSKSVVEASVMALVDGLDYYLQLKKT 543 >UniRef50_Q12166 2-isopropylmalate synthase 2, mitochondrial n=8 Tax=cellular organisms RepID=LEU9_YEAST Length = 604 Score = 389 bits (999), Expect = e-106, Method: Composition-based stats. Identities = 131/549 (23%), Positives = 216/549 (39%), Gaps = 48/549 (8%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + + T LRDG Q+L +SV +K + L +G +EV FP +S DF+ + Sbjct: 56 IQKAPRWLSTDLRDGNQSLPDPMSVAQKKEYFHKLINIGFKEIEVSFPSASQTDFDFTRY 115 Query: 61 IARQVKN-SRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + + L + E I E+L A+ IHT++ATS M + +E I Sbjct: 116 AVENAPDDVGIQCLVQSREHLIKRTVEALTGAKRATIHTYLATSDMFREIVFNMSREEAI 175 Query: 120 ERAIYMVKRARNYT----------DDVEFSCEDAGRTPIADLARVVEAAINAGATT---- 165 +A+ K R T EFS E TP + EA A T Sbjct: 176 SKAVEATKLVRKLTKDDPSQQATRWSYEFSPECFSDTPGEFAVEICEAVKKAWEPTEENP 235 Query: 166 --INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGAR 223 N+P TV P +A I + +K IS H H+D G V + + AGA Sbjct: 236 IIFNLPATVEVASPNVYADQIEYFSTHITEREKVCISTHCHNDRGCGVAATELGMLAGAD 295 Query: 224 QVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 +VEG + G GER GN L V M + + V ++ ++ S++V + +PIP Sbjct: 296 RVEGCLFGNGERTGNVDLVTVAMNMYTQG----VSPNLDFSDLTSISEIVHRCNKIPIPP 351 Query: 284 NKAIVGSGAFAHSSGIHQDGVLKN---------------RENYEIMTPESIGLN-QIQLN 327 G + SG HQD + K R Y + P+ IG + + + Sbjct: 352 RAPYGGELVVSAFSGSHQDAIKKGFAIQNKKQAQGETRWRIPYLPLDPKDIGRDYEAVIR 411 Query: 328 LTSRSGRAAVKH-RMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQ-- 384 + S+SG+ M +G + + K AD G+ + F Sbjct: 412 VNSQSGKGGAAWVIMRSLGLDVPRPMQVDFSNTLQKNADALGRELKSEEITKLFKETYNY 471 Query: 385 -QEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYN 443 E + L + V+ + + ++ ++V GNGP+ ++ A++ + Sbjct: 472 NNNEHIYVTLLNYEVKKLNPERRALVGQVEINDKVVNIEGYGNGPISSLVDALSNLLNVK 531 Query: 444 VELVKYSLTAKGHGKDALGQVDIVAN-------YNGRRFHGVGLATDIVESSAKAMVHVL 496 + + YS + G G I + + GVG++ D ++S KA+ + Sbjct: 532 LSVQNYSEHSLGSGSATQAASFINLSYIKDINNHATSNMWGVGVSEDTGDASIKAVFATV 591 Query: 497 NNIWRAAEV 505 NNI + +V Sbjct: 592 NNIIHSGDV 600 >UniRef50_P74269 Uncharacterized AIPM/Hcit synthase family transferase sll1564 n=103 Tax=cellular organisms RepID=LY41_SYNY3 Length = 547 Score = 388 bits (996), Expect = e-106, Method: Composition-based stats. Identities = 135/529 (25%), Positives = 239/529 (45%), Gaps = 33/529 (6%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 + ++DTTLRDG Q SLS+ +KL IA L+++G+ +E G+P ++P D + + Sbjct: 7 SLWLYDTTLRDGAQREGISLSLTDKLTIARRLDQLGIPFIEGGWPGANPKDVQFFWQLQE 66 Query: 64 QVKN-SRVCALARCVEK----DIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEV 118 + + + A + D +++ A + F + +H+ L+++L E Sbjct: 67 EPLEQAEIVAFCSTRRPHKAVETDKMLQAILSAGTRWVTIFGKSWDLHVLEGLQTSLAEN 126 Query: 119 IERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGYT 175 + + R+ V + E D R + A AGA + + DT G T Sbjct: 127 LAMISDTIAYLRSQGRRVIYDAEHWFDGYRANPDYALATLATAQQAGAEWLVMCDTNGGT 186 Query: 176 MPFEFAGIISGLYERVP----NIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNG 231 +P + + I + + + + + + +H H+D G AV NSL AV AGA V+G +NG Sbjct: 187 LPGQISEITTKVRRSLGLDGQSDRQPQLGIHAHNDSGTAVANSLLAVEAGATMVQGTING 246 Query: 232 IGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSG 291 GER GN +L +I ++++ D + + TS+L+S+I N+ + VG Sbjct: 247 YGERCGNANLCTLIPNLQLKLDYDCIEPE-KLAHLTSTSRLISEIVNLAPDDHAPFVGRS 305 Query: 292 AFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEY 351 AFAH GIH V +N YE + P +G + ++ ++ ++G + V + + G Sbjct: 306 AFAHKGGIHVSAVQRNPFTYEHIAPNLVGNER-RIVVSEQAGLSNVLSKAELFGIALDRQ 364 Query: 352 N-LDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQ--EEPEHFRLDYFSVQSGSNDIAT- 407 N A LK +++G F+ + + +Q + F + F V A Sbjct: 365 NPACRTILATLKDLEQQGYQFEAAEASFELLMRQAMGDRQPLFLVQGFQVHCDLLTPAEN 424 Query: 408 -------AAVKLACGEEVKAEAANGNGPVDAVYQAINRITEY------NVELVKYSLTAK 454 A VK+ + E A GNGPV A+ QA+ + + L Y + Sbjct: 425 PAYRNALATVKVTVNGQNILEVAEGNGPVSALDQALRKALTRFYPQIADFHLTDYKVRIL 484 Query: 455 --GHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWR 501 G G A +V + ++ RR+ VG++ +I+E+S +A+V + R Sbjct: 485 DGGAGTSAKTRVLVESSNGDRRWTTVGVSGNILEASYQAVVEGIEYGLR 533 >UniRef50_Q57926 2-isopropylmalate synthase 1 n=16 Tax=Euryarchaeota RepID=LEU11_METJA Length = 398 Score = 388 bits (996), Expect = e-106, Method: Composition-based stats. Identities = 144/388 (37%), Positives = 212/388 (54%), Gaps = 12/388 (3%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + + I+DTTLRDGEQ + ++KL+IA L+ +G+ +E GFP+ S + + V+TIA Sbjct: 22 KDIYIYDTTLRDGEQTPGVCFTKEQKLEIARKLDELGLKQIEAGFPIVSEREADIVKTIA 81 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKL-RSTLDEVIER 121 + N+ + AL R ++KDID A E + I TFIATSP+H+ K +LDE++E Sbjct: 82 NEGLNADILALCRALKKDIDKAIE----CDVDGIITFIATSPLHLKYKFNNKSLDEILEM 137 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 + V+ A+ + V FS EDA RTPI DL +V +AA AGA ++I DT G P Sbjct: 138 GVEAVEYAKEHGLFVAFSAEDATRTPIEDLIKVHKAAEEAGADRVHIADTTGCATPQSME 197 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 I L E + KA I VH H+D G AV NS+ + GA+ V +NGIGERAGN +L Sbjct: 198 FICKTLKENLK---KAHIGVHCHNDFGFAVINSIYGLIGGAKAVSTTVNGIGERAGNAAL 254 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EE+IMA+ V D V +N + + ++V + + +P NK IVG FAH SGIH Sbjct: 255 EELIMALTVLYD---VDLGLNLEVLPELCRMVEEYSGIKMPKNKPIVGELVFAHESGIHV 311 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 D V++N YE PE IGL + + L SG AV +++ MG L + Sbjct: 312 DAVIENPLTYEPFLPEKIGLKRN-ILLGKHSGCRAVAYKLKLMGIDYDREMLCEIVKKVK 370 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPE 389 ++ ++ + D + + ++ Sbjct: 371 EIREEGKFITDEVFKEIVEEVLRKRNKN 398 >UniRef50_P06208 2-isopropylmalate synthase n=109 Tax=cellular organisms RepID=LEU1_YEAST Length = 619 Score = 387 bits (995), Expect = e-106, Method: Composition-based stats. Identities = 128/549 (23%), Positives = 217/549 (39%), Gaps = 47/549 (8%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +++ T LRDG Q+L +SV++K + L +G +EV FP +S DF+ + Sbjct: 57 ITRAPRWLSTDLRDGNQSLPDPMSVEQKKEYFHKLVNIGFKEIEVSFPSASQTDFDFTRY 116 Query: 61 IARQVKN-SRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + + L + E I E+L A+ IHT++ATS M + +E I Sbjct: 117 AVENAPDDVSIQCLVQSREHLIKRTVEALTGAKKATIHTYLATSDMFREIVFNMSREEAI 176 Query: 120 ERAIYMVKRARNYT----------DDVEFSCEDAGRTPIADLARVVEAAINAGATT---- 165 +A+ K R T EFS E TP + EA A T Sbjct: 177 SKAVEATKLVRKLTKDDPSQQATRWSYEFSPECFSDTPGEFAVEICEAVKKAWEPTEENP 236 Query: 166 --INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGAR 223 N+P TV P +A I + +K IS H H+D G V + + AGA Sbjct: 237 IIFNLPATVEVASPNVYADQIEYFATHITEREKVCISTHCHNDRGCGVAATELGMLAGAD 296 Query: 224 QVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 +VEG + G GER GN L V M + + V ++ ++ +V + +P+ Sbjct: 297 RVEGCLFGNGERTGNVDLVTVAMNMYTQG----VSPNLDFSDLTSVLDVVERCNKIPVSQ 352 Query: 284 NKAIVGSGAFAHSSGIHQDGVLKN---------------RENYEIMTPESIGLN-QIQLN 327 G SG HQD + K R Y + P+ IG + + + Sbjct: 353 RAPYGGDLVVCAFSGSHQDAIKKGFNLQNKKRAQGETQWRIPYLPLDPKDIGRDYEAVIR 412 Query: 328 LTSRSGRAAVKH-RMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQE 386 + S+SG+ + +G A AD G+ D + F Sbjct: 413 VNSQSGKGGAAWVILRSLGLDLPRNMQIEFSSAVQDHADSLGRELKSDEISKLFKEAYNY 472 Query: 387 EPEHFR---LDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYN 443 E ++ L ++V+ + ++ G+++ GNGP+ ++ A++ + Sbjct: 473 NDEQYQAISLVNYNVEKFGTERRVFTGQVKVGDQIVDIEGTGNGPISSLVDALSNLLNVR 532 Query: 444 VELVKYSLTAKGHGKDALGQVDIVAN-----YNGRRF-HGVGLATDIVESSAKAMVHVLN 497 + Y+ + G G I + N + + GVG++ D+ +SS +A+ +N Sbjct: 533 FAVANYTEHSLGSGSSTQAASYIHLSYRRNADNEKAYKWGVGVSEDVGDSSVRAIFATIN 592 Query: 498 NIWRAAEVE 506 NI + +V Sbjct: 593 NIIHSGDVS 601 >UniRef50_A8L551 2-isopropylmalate synthase n=38 Tax=Bacteria RepID=LEU1_FRASN Length = 565 Score = 387 bits (995), Expect = e-106, Method: Composition-based stats. Identities = 126/536 (23%), Positives = 207/536 (38%), Gaps = 40/536 (7%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +++ LRDG QAL ++ K+Q+ L MG +EVGFP +S DF+ V+ Sbjct: 33 ITEAPRWCSVDLRDGNQALIDPMTPSRKMQLFELLVAMGYKEIEVGFPAASQTDFDFVRQ 92 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + + L + E+ I+ SL ++ IH + +TS + Sbjct: 93 LIEDDLIPDDVTIQVLTQAREELIERTVTSLVGSDRALIHLYNSTSTLQRRVVFGLDRAG 152 Query: 118 VIERAIYMVKRARNY------TDDVEF--SCEDAGRTPIADLARVVEAAINAGATT---- 165 V + A+ + Y DV + S E T + V EA ++ A T Sbjct: 153 VTDIAVQGARWCAQYAEKLLEGTDVRWQYSPESFTGTELDYALEVCEAVMDVWAPTPDNP 212 Query: 166 --INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGAR 223 +N+P TV + P +A I + + D ++S+H H+D G AV + V AGA Sbjct: 213 VVLNLPATVEMSTPNVYADQIEWMSRNLTRRDAVVLSLHPHNDRGCAVAAAELGVMAGAD 272 Query: 224 QVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 +VEG + G GER GN L + M + + + I+ +I + V +P+ Sbjct: 273 RVEGCLFGNGERTGNVCLVTLGMNLFSQG----IDPMIDLSDIDGVRRTVEYCNQLPVHP 328 Query: 284 NKAIVGSGAFAHSSGIHQDGVLKNREN------------YEIMTPESIGLN-QIQLNLTS 330 G + SG HQD + K E Y + P+ +G + + + + S Sbjct: 329 RHPYGGDLVYTAFSGSHQDAIKKGFEAMERTGQTLWEVPYLPIDPKDVGRSYEAVIRVNS 388 Query: 331 RSGRAAVKHRMD-EMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPE 389 +SG+ V + M E K D G F + + E Sbjct: 389 QSGKGGVAYLMKSEYALDLPRRLQIEFSGVVQKHTDDAGGEVTAGQLWEIFTREYRPEGG 448 Query: 390 H----FRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVE 445 L + S V + +GNGP+DA A++ V Sbjct: 449 DPAASLELLGSRTTAASGARDEVTVSVRLDGTETVITGSGNGPIDAFVAALSE-RGVPVR 507 Query: 446 LVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWR 501 ++ Y+ A G G DA + GVG+ +IV +S +A+V +N R Sbjct: 508 VLDYNEHALGSGADARAAAYLEVAVGETVLWGVGIDPNIVTASLRAVVSAVNRASR 563 >UniRef50_B9KY22 2-isopropylmalate synthase/homocitrate synthase family protein n=4 Tax=Bacteria RepID=B9KY22_THERP Length = 562 Score = 387 bits (993), Expect = e-106, Method: Composition-based stats. Identities = 143/518 (27%), Positives = 248/518 (47%), Gaps = 31/518 (5%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 ++V+I+DTTLRDG Q SL+ ++KL+IA AL+ +GV +E G+P S+P D + Sbjct: 30 RRVVIYDTTLRDGTQGSGVSLTTEDKLKIARALDELGVAYIEGGWPGSNPKDMAFFERAR 89 Query: 63 -RQVKNSRVCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 +Q +++R+ A DV L AE + SP + L +TLDE Sbjct: 90 HQQWRHARITAFGSTRRAGGTVEEDVNLRLLLEAETPAVTIVGKASPFQVRVILGTTLDE 149 Query: 118 VIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGY 174 + V + +V F E D V+ AA +AGA + + DT G Sbjct: 150 NLRMVAESVAFLKAAGREVIFDAEHFFDGYAEDPDYALAVLRAACDAGADAVVLCDTNGG 209 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 T+ ++ + + ++ + +HTH+D LAV N++AAV AGA V+G MNG+GE Sbjct: 210 TL---TDPLVRAVRHALSSV-SCTVGIHTHNDCELAVANTIAAVLAGAMHVQGTMNGLGE 265 Query: 235 RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFA 294 R GN +L +I ++ + + N +++ TS+ V+++ N+ VG+ AF Sbjct: 266 RIGNANLCSIIPILEYKLGYRCLPPG-NLRKLTETSRYVAEVANLAHDPRLPFVGAFAFT 324 Query: 295 HSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESE--YN 352 H +G+H + + K+ YE + PE +G + L + SGR+ + + G + + Sbjct: 325 HKAGLHVNAIAKHPSAYEHIPPEVVGNTRHVLV-SELSGRSNIVVKARSFGIELGDKPEV 383 Query: 353 LDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQ--EEPEHFRLDYFSVQS----GSNDIA 406 + + + +L + G F+ +L + ++ + F + ++V + G +A Sbjct: 384 VRRVLEQIKEL-EFHGYWFEDADASLELLIRRNLPDYRPPFEVLDYTVLTEYRNGRGMLA 442 Query: 407 TAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEY------NVELVKYSLTAKG--HGK 458 A VKL G+ V AA GNGPV+A+ +A + + V+L Y + HG Sbjct: 443 EAMVKLRIGQHVFHTAAEGNGPVNALDRATRKALQEFYPEIAAVDLEDYKVRVLDDHHGT 502 Query: 459 DALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVL 496 A +V I + ++ VG + +I+E+S A+ L Sbjct: 503 GAKVRVWIRSGDAHGSWNTVGSSENIIEASWLALADSL 540 >UniRef50_D1PA75 (R)-citramalate synthase n=1 Tax=Prevotella copri DSM 18205 RepID=D1PA75_9BACT Length = 532 Score = 385 bits (989), Expect = e-105, Method: Composition-based stats. Identities = 131/523 (25%), Positives = 222/523 (42%), Gaps = 30/523 (5%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALAL-ERMGVDVMEVGFPVSSPGDFESVQTI 61 +++ I D TLRDGEQ S EKL IA L + VD +EV S G+ ++V I Sbjct: 13 KEIEIMDCTLRDGEQTNGVSFLPHEKLMIARMLLHDINVDRIEVASARVSEGEKDAVARI 72 Query: 62 ARQVKN------SRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 R K V D + + + + I+ S H +L+ + Sbjct: 73 CRYAKTIGKLDSVEVLGFV-----DNNKSVDWIAECGGHVINLLAKGSYKHCTQQLKMSP 127 Query: 116 DEVIERAIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTV 172 +E + + A + V ED R L +++ + +PDT+ Sbjct: 128 EEHLAHIKQTIGYALSKGFTVNLYLEDWSSGMRDSRDYLFMMMDELVKQPIKRFLLPDTL 187 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G P + + + R PN H H+D LAV NSLAAV +GA+ + +NG+ Sbjct: 188 GILNPLQCVEYMRQMVRRYPNS---HFDFHAHNDYDLAVSNSLAAVLSGAKGLHVTVNGL 244 Query: 233 GERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 GER GN L V + +K D+ T I + S+LV + + N +VG Sbjct: 245 GERCGNAPLASVQVILK---DMFEAKTNIKEDRLNDISRLVEGYSGIAVAPNTPVVGDNV 301 Query: 293 FAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYN 352 F +G+H DG K++ + PE G ++ + L SG+A + ++E+G + + Sbjct: 302 FTQVAGVHADGDNKDKLYCNDLVPERFGRHR-EYALGKNSGKANIVQNLNELGLELTPEQ 360 Query: 353 LDNLYDAFLKLADKKGQVFDYDLEALA-FIGKQQEEPEHFRLDYFSVQSGSNDIATAAVK 411 + +L D+K V DL + + K + +L + V + A+VK Sbjct: 361 TKAVTKRITELGDRKELVTQDDLPYIVSDVLKHGAPEDKVKLVSYMVSTSYGLKPIASVK 420 Query: 412 LACGEEVKAEAANGNGPVDAVYQAINRITEYNV-----ELVKYSLTAKGHG-KDALGQVD 465 + + + ++G+G DA +A+ I + + +L Y +T G DAL Q Sbjct: 421 VEIEGKEYEDQSSGDGQYDAFVKALRNIYKVKLGKTFPKLDNYQVTIPPGGRTDALVQTV 480 Query: 466 IVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKE 508 I R + GL D E++ KA + ++N ++ A + + + Sbjct: 481 ITWREGDRIWRTRGLDADQTEAAIKATLKMIN-MYEADKSDDQ 522 >UniRef50_Q7VH30 2-isopropylmalate synthase n=16 Tax=Bacteria RepID=LEU1_HELHP Length = 558 Score = 384 bits (987), Expect = e-105, Method: Composition-based stats. Identities = 118/537 (21%), Positives = 210/537 (39%), Gaps = 41/537 (7%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +++ I LRDG QAL +S++EK+ L ++G +EVGFP +S ++ ++T Sbjct: 26 IAKAPIWCSVDLRDGNQALITPMSLEEKITFFKLLLKVGFKEIEVGFPAASETEYRFLRT 85 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + + V L + E I ESL+ + +H + +TS R + DE Sbjct: 86 LIEEDLIPDDVSVQVLTQAREHIIKKTFESLEGCKNAIVHVYNSTSYAQREQVFRKSKDE 145 Query: 118 VIERAIYMV------KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATT------ 165 + A A E+S E T + V A I+ T Sbjct: 146 IKHIACEGAICLKESAAATKGNFRFEYSPESFSGTEVDYALEVCNAVIDIFEPTLEKKLI 205 Query: 166 INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQV 225 IN+P TV ++P +A + + + + N + +IS+H H+D G A+ ++ + AGA ++ Sbjct: 206 INLPVTVEMSLPHIYASQVEYMSKHLKNRENVLISLHPHNDRGCAIADAELGLLAGADRI 265 Query: 226 EGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANK 285 EG + G GER GN + + M + V ++ I + ++ M + + Sbjct: 266 EGTLFGNGERTGNVDIITLAMNMHSHG----VDPKLDFSNIPSICDVYEKVTKMQVYERQ 321 Query: 286 AIVGSGAFAHSSGIHQDGVLKNRE------------NYEIMTPESIGL--NQIQLNLTSR 331 G FA SG HQD + K Y + P+ +G + + S+ Sbjct: 322 PYSGKLVFAAFSGSHQDAIAKGMAYHKEHNLSTWSVPYLPIDPKDVGRVYESDVIRINSQ 381 Query: 332 SGRAAVKHRMDEM-GYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEH 390 SG+ + + + G + ++DK + D F Sbjct: 382 SGKGGIAYILHHHYGVNLPPLFREEFSYYVKNISDKAHKELSPDEICEIFQNDFVNLNNT 441 Query: 391 FRLDYFSVQS-GSNDIATAAVKLA------CGEEVKAEAANGNGPVDAVYQAINRITEYN 443 + F S VKL + + GNG +D++ A+ + Sbjct: 442 LCVQDFHFTHIDSKPSQEFNVKLHILYAKENSKTQQEITGKGNGRLDSIANALREHLNLD 501 Query: 444 VELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIW 500 E++ YS + G + + G++ GVG+ DI+ +S +V LN I Sbjct: 502 FEIIDYSEHSLKKGSTSQAVSYVQIESKGKKCFGVGIDNDIITASIYGLVSALNRII 558 >UniRef50_Q02CM5 2-isopropylmalate synthase n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q02CM5_SOLUE Length = 536 Score = 384 bits (986), Expect = e-105, Method: Composition-based stats. Identities = 138/516 (26%), Positives = 244/516 (47%), Gaps = 29/516 (5%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 ++ FDTTLRDG Q S SV +KL IA L+ +G+D +E G+P S+P D + Sbjct: 2 KIFTFDTTLRDGTQGESISFSVDDKLIIAQKLDDLGIDYIEGGWPGSNPKDKDFFARSGE 61 Query: 64 Q-VKNSRVCALARCV----EKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEV 118 +K+S++ A + D ++L A + F + +H+ L +L+E Sbjct: 62 LNLKHSKLTAFGSTRFAKNPVEEDRNVKALVEAGTPVVSIFGKSWDLHVRRALGISLEEN 121 Query: 119 IERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGYT 175 + V + +V + E D R +EAA AGA+ + + DT G T Sbjct: 122 LVLISDTVGYIHGHGREVVYDAEHFFDGYTADPDYALRTLEAAHKAGASVLCLCDTNGGT 181 Query: 176 MPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGER 235 + I++ + +R I I +HTH+D LAV N++AAV AGA V+G MNG GER Sbjct: 182 VTGRLVEIVAEVRKRFDGI----IGIHTHNDGDLAVANTIAAVEAGATHVQGCMNGYGER 237 Query: 236 AGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAH 295 GN +L VI ++++ V + T + ++++ N+P+ ++ VG AFAH Sbjct: 238 CGNANLASVIANLELKLGHTTVGPE-KLAGLSSTCRFIAELANLPLRNDQPFVGKSAFAH 296 Query: 296 SSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGY-KESEYNLD 354 G+H VLK+ YE + PE++G N+ ++ ++ SGR + +++ + G E + Sbjct: 297 KGGVHVSAVLKDSATYEHIKPEAVG-NRQRVLVSDLSGRGNIIYKLKQHGLADRLEEDTR 355 Query: 355 NLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEP--EHFRLDYFSVQSGSND----IATA 408 + +K + +G + + ++ P F ++ + V + + +TA Sbjct: 356 RVLLERIKQMEYEGYELEAAEGTFELLVREALHPGMHFFDVESYEVSTRAAGNAASHSTA 415 Query: 409 AVKLACGEEVKAEAANGNGPVDAVYQAINRITE------YNVELVKYSLTAK--GHGKDA 460 V L + V + G+GP DA+ + + +V L Y + G A Sbjct: 416 TVTLKSQDGVHSATETGHGPFDALQVCLRKCLSKLYPQIVDVRLTDYKVRVLDTNKGTAA 475 Query: 461 LGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVL 496 +V I + + R + VG++ +++E+S KA+V + Sbjct: 476 NVRVLIEWSDHRRSWSTVGVSDNVIEASWKALVDAI 511 >UniRef50_A4A2P3 2-isopropylmalate synthase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A4A2P3_9PLAN Length = 542 Score = 383 bits (984), Expect = e-105, Method: Composition-based stats. Identities = 141/539 (26%), Positives = 245/539 (45%), Gaps = 28/539 (5%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ I+DTTLRDG Q S S+++KL I L+ +GVD +E G+P+S+ D E + + Sbjct: 2 RKIEIYDTTLRDGAQGEGVSFSLQDKLSITERLDEIGVDFVEGGYPLSNEKDAEYFRRVQ 61 Query: 63 RQ-VKNSRVCALARCVEKDIDVA----AESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 +K+++VCA K I+ A ++L + A + T H+ LR TL+E Sbjct: 62 DLNLKHTKVCAFGMTRRKGINAADDPGMQALVSSGAPVVTIVGKTHDFHVTDVLRVTLEE 121 Query: 118 VIERAIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTVGY 174 + V +V + E + A + AA AGA + + DT G Sbjct: 122 NLAMIADSVAYIVGAGREVIYDAEHFFDGWKANPEYAAETIRAAAKAGARMVVMCDTNGG 181 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 ++P E A + + + +HTH+D LAV NSLAAV AGA QV+G +NG GE Sbjct: 182 SLPEEIAEYAAKAIAALTEF-NVPVGIHTHNDGDLAVANSLAAVDAGAVQVQGTINGFGE 240 Query: 235 RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFA 294 R GN L VI + +++ V +Q + S+ V N+ N+A VG AFA Sbjct: 241 RCGNADLISVIANLGLKRKGYEVIGGAGYQHLTELSRFVYDTANVNRRNNQAFVGQSAFA 300 Query: 295 HSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLD 354 H G+H + + +YE + P+S+G + L + SGR+ + + ++ +D Sbjct: 301 HKGGMHVHAINRAASSYEHIDPQSVGNERRVLV-SELSGRSNIVALTTKHNLQDDRELMD 359 Query: 355 NLYDAFLKLADKKGQVFDYDLEALAFIGKQQE--EPEHFRLDYFSVQSGS-------NDI 405 + + + +G F+ + + K+ HF + + V+ + + Sbjct: 360 KILAEVVA-KENQGFQFEAAEASFDLLVKRVAGVFEPHFEILKYHVEVEDLVEHKMVDLV 418 Query: 406 ATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITE------YNVELVKYSLTAKG--HG 457 A VK++ E++ E G+GPV A+ A+ + + LV Y + G Sbjct: 419 TEATVKVSVDGEIRYEVGEGDGPVQALDVALRKSLNGCFPTLEEMHLVDYKVRVVNQEAG 478 Query: 458 KDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHN 516 A +V I + + +G++ +I+++S A+V + E +L +A + Sbjct: 479 TAARIRVTIESADENDVWGTIGVSENIIQASWNALVDAIEYKLYKDEQRGKLPARASAD 537 >UniRef50_D2MJY3 2-isopropylmalate synthase n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MJY3_9BACT Length = 405 Score = 383 bits (983), Expect = e-104, Method: Composition-based stats. Identities = 186/398 (46%), Positives = 261/398 (65%), Gaps = 7/398 (1%) Query: 112 RSTLDEVIERAIYMVKRARNYTDD-----VEFSCEDAGRTPIADLARVVEAAINAGATTI 166 R+T ++ + A V A++ +D VEFS DAGRT +A L VVEA I AGAT + Sbjct: 6 RTTPEDTLRMATAAVAYAKSLCEDHPDANVEFSPMDAGRTELAFLYEVVEATIAAGATVV 65 Query: 167 NIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVE 226 NIP+TVG+T+P EF +I + E VPN+D AIISVH H+DLGLAV NSL A+ GARQVE Sbjct: 66 NIPETVGWTVPTEFGNLIKSIMENVPNVDDAIISVHCHNDLGLAVANSLIAIEQGARQVE 125 Query: 227 GAMNGIGERAGNCSLEEVIMAIKVRKDIL-NVHTAINHQEIWRTSQLVSQICNMPIPANK 285 +NG+GERAGN SLEEV+MAI+ R+D N +T IN +EI S+ VS+ + + NK Sbjct: 126 CTINGLGERAGNTSLEEVVMAIRTRRDYFKNYYTEINAKEIVPISRRVSRTMGIAVQPNK 185 Query: 286 AIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMG 345 AIVG+ AFAHSSGIHQDG++K+R +EI+ P+ IG + QL L+ RSGR A++HR+ E+G Sbjct: 186 AIVGANAFAHSSGIHQDGIIKSRVTFEIIDPQEIGWKESQLILSPRSGRNALRHRLSELG 245 Query: 346 YKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDI 405 Y+ LD +Y+ FLK+ADKK + D DLEA+ + + P F LDY V SG+ Sbjct: 246 YEVEGAQLDKVYERFLKVADKKKSIQDADLEAIM-SDEIRAIPAIFELDYIQVVSGTKIS 304 Query: 406 ATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVD 465 T V + + V +A+ G+GPVDA ++AI ++ + + LV Y + + G+DA+G+V Sbjct: 305 PTTTVGIRTEDGVVEKASTGDGPVDAAFKAIAQVVDIQLNLVDYQIRSVTEGEDAIGEVS 364 Query: 466 IVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAA 503 + NG G G +TDI+E+SA+A +H +N + + Sbjct: 365 LKVQDNGHIITGHGASTDIIEASARAYIHAVNKLIQIR 402 >UniRef50_A8HXS9 Isopropylmalate synthase (Fragment) n=1 Tax=Chlamydomonas reinhardtii RepID=A8HXS9_CHLRE Length = 444 Score = 382 bits (981), Expect = e-104, Method: Composition-based stats. Identities = 174/459 (37%), Positives = 255/459 (55%), Gaps = 42/459 (9%) Query: 79 KDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTD-DVE 137 +D++ A ++++ A+ R+HTFIATS +H+ + + + A+ VK R+ D+E Sbjct: 1 QDLERAWDAVRHAKRPRVHTFIATSEIHMKVSQQGSATSGLHNAVAAVKHLRSLGCTDIE 60 Query: 138 FSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKA 197 FS EDAGR+ L R++ I AGATT+NIPDT G+ +P EF +I+ + + P D Sbjct: 61 FSSEDAGRSDPKFLYRILGEVIKAGATTLNIPDTTGWCLPHEFGELIAAIKKNTPGADNV 120 Query: 198 IISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNV 257 IIS H +DLGL+ NSLA AGARQ+E +NGIGERAGN SLEEV+MAIK+R Sbjct: 121 IISTHCQNDLGLSTANSLAGAQAGARQIECTINGIGERAGNASLEEVVMAIKLRG----- 175 Query: 258 HTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPE 317 ++VS M + A+KAIVG+ AFAH SGIHQDG+LKNRE YEIM+PE Sbjct: 176 -------------KMVSDYSGMVVQAHKAIVGANAFAHESGIHQDGMLKNRETYEIMSPE 222 Query: 318 SIGLNQIQ----LNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDY 373 SIGL + + + L SGR A+ R+ +GY+ S+ LD+++ F LADKK + D Sbjct: 223 SIGLPRQEQDRGIVLGKHSGRNALNSRLRTLGYELSQSELDDVFKRFKALADKKKGITDE 282 Query: 374 DLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEV-KAEAANGNGPVDAV 432 D+ AL + + + L V G+ + TA V++ + + + G GPVDA Sbjct: 283 DILALM-SDELHQPKVIWELLDLQVVCGTMGMPTATVQMKGPDGIARIGVGVGTGPVDAA 341 Query: 433 YQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNG-----------------RRF 475 Y+A++ + EL YS+++ G +AL ++ +G R+F Sbjct: 342 YKAVDSLVRVEAELSDYSVSSVTQGIEALAHTRVMIRPSGKMSDAGYSEHAALGTVQRQF 401 Query: 476 HGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQ 514 G G DIV +SA+A V LN + V + + + Sbjct: 402 SGSGANEDIVVASARAYVSALNKMIGWRRVGRRREWASS 440 >UniRef50_A8ZTR1 2-isopropylmalate synthase/homocitrate synthase family protein n=3 Tax=Bacteria RepID=A8ZTR1_DESOH Length = 542 Score = 382 bits (980), Expect = e-104, Method: Composition-based stats. Identities = 139/527 (26%), Positives = 239/527 (45%), Gaps = 37/527 (7%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +QV I+DTTLRDG Q + +V EK+++A L+ +GV +E G+P S+P D + + A Sbjct: 2 EQVRIYDTTLRDGMQGDTINFTVDEKIRVARQLDDLGVHYIEGGWPGSNPRDVQFFEKAA 61 Query: 63 R-QVKNSRVCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + KN+R+ A + D L A + T +HI + +TL+ Sbjct: 62 KIDFKNARLTAFGSTRRAGLAVEKDDNIRLLLECGAPAVALVGKTWDLHITEVMSNTLES 121 Query: 118 VIERAIYMVKRARNYTDDVEFSCEDAGR---TPIADLARVVEAAINAGATTINIPDTVGY 174 +E V +++ +V F E + + A AGA + + DT G Sbjct: 122 NLEMIHDSVAYVKSHGREVFFDAEHFFDGCTHNREYTFKAILTAAQAGADAVILCDTNGG 181 Query: 175 TMPFEFAGIISGLYERVPNIDK-------AIISVHTHDDLGLAVGNSLAAVHAGARQVEG 227 +P + I + + + + + +HTH+D LAV NS+AA+ AGAR V+G Sbjct: 182 ALPHDVEAITAEVCTTLADRFPGPDGGSTVQVGIHTHNDSNLAVANSIAAIRAGARIVQG 241 Query: 228 AMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAI 287 +NG GER GN L +I + + + + T N +++ + S+ VS+ NM ++ Sbjct: 242 TINGYGERCGNADLTSIIPILAAKMEYDCI-TPENLKKLRKVSRFVSETANMTPVNSRPF 300 Query: 288 VGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK 347 VG AF+H G+H ++KN YE M PE +G + ++ ++ SGR+ V ++ E+G Sbjct: 301 VGKSAFSHKGGLHVSAIMKNPRAYEHMDPELVGNKR-RVLISDLSGRSNVTYKARELGIN 359 Query: 348 ESEY--NLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQE--EPEHFRLDYFSVQ---- 399 ++D + L + +G FD + + ++ F L F V Sbjct: 360 TDTEHFDVDRILSEVKML-ELEGFQFDAADGSFKIVMEKISGLYTPLFDLLSFRVTVEKE 418 Query: 400 SGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEY---------NVELVKYS 450 A A ++L GE AA G+GPV A+ A+ ++LV + Sbjct: 419 KDRPCTAHATIRLGVGELETTTAAEGDGPVSALDTALRMAIAEFYPDSLGLDAMQLVDFK 478 Query: 451 LTAKGH--GKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHV 495 + G A +V I + + +G++ DI+E+S +A+ Sbjct: 479 VRVLDGRDGTSAKVRVLIDSRDEDEVWGTIGVSEDIIEASWEALADS 525 >UniRef50_B3TC58 Putative HMGL-like protein n=1 Tax=uncultured marine microorganism HF4000_APKG10H11 RepID=B3TC58_9ZZZZ Length = 530 Score = 380 bits (976), Expect = e-104, Method: Composition-based stats. Identities = 126/527 (23%), Positives = 246/527 (46%), Gaps = 32/527 (6%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + + I DTTLRDG Q + +++EK+ IA L+ +GV+++E G+P S+P D E + I Sbjct: 9 KTIEILDTTLRDGSQMRGVNFTLQEKIMIATKLDDLGVNIIEGGWPGSNPKDLEFFKLIK 68 Query: 63 R-QVKNSRVCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + +++NS++ K+I D + + +EA TS H+ L +L++ Sbjct: 69 KHELRNSKIAVFGSTRRKNITAKNDNNLKVMVDSEALVSVIVGKTSSFHVEKILNCSLED 128 Query: 118 VIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGY 174 +E + R F E D + V+ A A TI + DT G Sbjct: 129 NLEMIYDSLIFLRESGLQTYFDAEHFFDGYNINPEYAIQTVKTAEEAKVNTIVLCDTNGG 188 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 +P + ++ + + + I H H+D G AV N+++AV AGA ++G +NG+GE Sbjct: 189 MLPHQIERVVKKIKKN----SEVKIGFHGHNDTGCAVANTVSAVVAGATHIQGTINGLGE 244 Query: 235 RAGNCSLEEVIMAIKVRKDILNVHTA----INHQEIWRTSQLVSQICNMPIPANKAIVGS 290 R GN L +VI ++++ + IN ++ S ++++ N+ ++ G Sbjct: 245 RTGNADLCQVIPNLEMKLKKKTRNIQKKQIINFGKLRDISNYINELVNINSFDHQPYFGK 304 Query: 291 GAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMG--YKE 348 AF+H +G+H DG+LK+ + YE + PE I ++ ++ SG+A + + + Sbjct: 305 FAFSHKAGLHVDGMLKSSKAYEHINPE-IFKSERSFTISELSGKANIIALSKKFNFQIDK 363 Query: 349 SEYNLDNLYDAFLKLADKKGQVFD--YDLEALAFIGKQQEEPEHFRLDYFSVQSG--SND 404 + + ++ + KL + G D L F+ ++F +D + V + + Sbjct: 364 DDKRIIDILEEIKKL-EFSGFTLDNADATTYLIFLRHLGLYKQYFHVDSWKVLTEKQNQI 422 Query: 405 IATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITE------YNVELVKYSLTAKGHGK 458 + + +K+ GE + A G GPV+++ A+ + + +EL Y ++ G K Sbjct: 423 NSKSEIKILIGENIYTNNAYGVGPVNSLAIALRKSLQNKYPEINKIELTNYKVSIVGASK 482 Query: 459 D--ALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAA 503 D +L +V I + + + +I+++S +A++ + + Sbjct: 483 DTASLVRVFIEFKKDEVVWATTATSQNILDASLRALIDGHDYFLQKN 529 >UniRef50_Q97MC5 2-isopropylmalate synthase n=50 Tax=Bacteria RepID=LEU1_CLOAB Length = 558 Score = 378 bits (971), Expect = e-103, Method: Composition-based stats. Identities = 118/533 (22%), Positives = 211/533 (39%), Gaps = 41/533 (7%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + I LRDG QAL ++V EK+++ L +G +E+GFP +S ++E + + Sbjct: 26 KAPIWCSVDLRDGNQALPKPMNVDEKIKMFKMLVDIGFKEIEIGFPSASETEYEFTRKLI 85 Query: 63 RQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 ++ + L + E + E+LK + +H + +TS + + DEV Sbjct: 86 EDKLIPEDVTIQVLTQAREHLVKKTFEALKGVKTAIVHVYNSTSELQRRVVFKKDKDEVK 145 Query: 120 ERAIYMVKRARNYTDDVEFS---------CEDAGRTPIADLARVVEAAINAGAT------ 164 AI + + Y++ E+S E T + V EA +N Sbjct: 146 SLAIKGAQMVKKYSEYTEYSESKFVFEYSPESFTGTELDYALEVCEAVLNVWKPSKENKA 205 Query: 165 TINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 IN+P TV P +A I +++ N + I+S+HTH+D G +S + AGA + Sbjct: 206 IINLPSTVEMATPNIYADQIEWFCKKLLNRESVILSLHTHNDRGTCTASSELGILAGADR 265 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 VEG + G GER GN IM + + V + + + + M + Sbjct: 266 VEGTLFGNGERTGNLD----IMNMALNMYSQGVDPELEFSNLNDIVEAYEECTKMVVHER 321 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNREN------------YEIMTPESIGLNQIQLN-LTSR 331 G F SG HQD + K ++ Y + P +G ++ + S+ Sbjct: 322 HPYAGKLVFTAFSGSHQDAIRKGLKSLKEGKNKHWEVPYLAVDPHDLGREYEEIIRINSQ 381 Query: 332 SGRAAVKHRMD-EMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEH 390 SG+ + M+ + G+ + K +D+ + F + E Sbjct: 382 SGKGGTAYIMESDFGFILPKAMHPEFGKVIKKKSDELDCELSPEQIFKFFKEEYLENRSP 441 Query: 391 FRLDYFSVQSGSND-----IATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVE 445 + L + + S N ++ + + GNGPVDA + A+N + Sbjct: 442 YYLKNYKIHSIQNIEEEKNTVDIEAVISVNGKDTSIEGVGNGPVDAFFNAMNNKKYNGCK 501 Query: 446 LVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNN 498 + Y A G + + +++ GVG++ +I +S A+V LN Sbjct: 502 FISYDEHALNIGSHSKAVAYVQIESQDKKYFGVGISDNIDTASINAIVSALNR 554 >UniRef50_Q3M862 2-isopropylmalate synthase n=4 Tax=Bacteria RepID=Q3M862_ANAVT Length = 577 Score = 378 bits (970), Expect = e-103, Method: Composition-based stats. Identities = 136/578 (23%), Positives = 252/578 (43%), Gaps = 70/578 (12%) Query: 1 MSQQ----VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFE 56 M++ + ++DTTLRDG Q S+S ++KL+IA L+++G+ +E G+P ++P D + Sbjct: 1 MTKNPSPHIWLYDTTLRDGTQREGLSISTEDKLRIAHRLDQLGIPFIEGGWPGANPKDVQ 60 Query: 57 SVQTIARQVKN-SRVCALARCVE----KDIDVAAESLKVAEAFRIHTFIATSPMHIATKL 111 + S++ A + + + A + + F + +H+ T L Sbjct: 61 FFWQLQEDPLKLSQIVAFCSTRRPHTHAADEPMLQDILAAGSSWVTIFGKSWDLHVTTGL 120 Query: 112 RSTLDEVIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINI 168 ++TL+E + ++ R+ V + E D + + ++AA+ AGA + + Sbjct: 121 KTTLEENLAMIRDTIEFFRSQGRRVIYDAEHWFDGYKHNRDYALQTLKAAMAAGAEWLVL 180 Query: 169 PDTVGYTMPFEFAGIISGLYERVPNIDKAI------------------------------ 198 DT G T+P E + I+ + + + + Sbjct: 181 CDTNGGTLPHEVSQIVQDVVKVTRDWGRINSKLDQSGQVVSEEVEKSTNSLPNTQYPIPN 240 Query: 199 -------ISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVR 251 I +HTH+D +AV N+LAAV AGA V+G +NG GER GN +L +I ++++ Sbjct: 241 LPFPIPQIGIHTHNDSDMAVANALAAVMAGATMVQGTINGYGERCGNANLCSLIPNLQLK 300 Query: 252 KDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENY 311 + ++ S+ VS++ N+ + VG AFAH GIH V +N Y Sbjct: 301 LGYSCITEH-QLGQLAEASRFVSEVVNLAPDEHAPFVGRSAFAHKGGIHVSAVERNPLTY 359 Query: 312 EIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEY--NLDNLYDAFLKLADKKGQ 369 E + PE +G N+ ++ ++ +SG + V + G + + + +L + +G Sbjct: 360 EHIQPEQVG-NRRRIVISEQSGISNVLAKARTFGIELDKQTPEAKQILQRLKEL-ESEGY 417 Query: 370 VFDYDLEALAFIGKQQE--EPEHFRLDYFSVQSG-----SNDIATAAVKLACGEEVKAEA 422 F+ + A + + + F + F V A A VK+A + EA Sbjct: 418 QFEAAEASFALLMYEALGGRQQFFEVKGFQVHCDLVEGKEMTNALATVKVAVNGKNILEA 477 Query: 423 ANGNGPVDAVYQAINRIT------EYNVELVKYSLTAKGH--GKDALGQVDIVANYNGRR 474 A GNGPV A+ A+ + EL Y + G A + + + +R Sbjct: 478 AEGNGPVAALDAALRKALVNFYPQLATFELTDYKVRILDGHTGTSAKTRALVESGNGYQR 537 Query: 475 FHGVGLATDIVESSAKAMVHVLNN-IWRAAEVEKELQR 511 + VG++ +I+ +S +A+V L + A+ E ++ Sbjct: 538 WTTVGVSPNILAASYQAVVEGLEYGLLLHAQAEAAVKA 575 >UniRef50_C8WRC1 2-isopropylmalate synthase n=14 Tax=Bacteria RepID=C8WRC1_ALIAD Length = 564 Score = 377 bits (967), Expect = e-103, Method: Composition-based stats. Identities = 125/532 (23%), Positives = 225/532 (42%), Gaps = 36/532 (6%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + I LRDG QAL ++++EKL L +G +EVGFP +S +FE V+T+ Sbjct: 29 RPPIWCSVDLRDGNQALIVPMNLEEKLAYFQLLVEIGFKEIEVGFPAASDTEFEFVRTLI 88 Query: 63 RQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + + + L + + I+ E+++ A+ +H + +TS R+ DE++ Sbjct: 89 ERDLVPSDVTIQVLTQSRDHIIERTFEAIRGAKRAIVHLYNSTSVAQREQVFRADKDEIV 148 Query: 120 ERAIYMVKRARNY------TDDVEFSCEDAGRTPIADLARVVEAAINAGATT------IN 167 A+ ++ R+ ++S E T + + A ++ T IN Sbjct: 149 NIAVTGAEQIRDLARTTPGNFFFQYSPESFTGTELDFALEICNAVLDVWKPTPDRKVIIN 208 Query: 168 IPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEG 227 +P TV +MP +A I + +R+ D ++SVH H+D G V + A+ AGA ++EG Sbjct: 209 LPATVELSMPHVYASQIEYMGKRLARRDAIVLSVHPHNDRGTGVAAAELAMLAGAERLEG 268 Query: 228 AMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAI 287 + G GER GN + + + + + ++ + V + M + Sbjct: 269 TLFGNGERTGNVDIVTLALNLYSHG----IDPGLDFSNLPAIQARVEALTKMQVSRRHPY 324 Query: 288 VGSGAFAHSSGIHQDGVLKNRE------------NYEIMTPESIGLNQI--QLNLTSRSG 333 G F SG HQD + K + Y + P+ IG + + S+SG Sbjct: 325 AGELVFTAFSGSHQDAIAKGMKWREEKSPEHWTVPYLPIDPKDIGREYEGDIIRINSQSG 384 Query: 334 RAAVKHRMDE-MGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFR 392 + + + +++ G+ + L A +++D++ + D A F+ + + Sbjct: 385 KGGIGYVLEQSHGFDLPPKMREQLGYAVKRVSDREQKELSADEIAEIFMREFVNLGQPLD 444 Query: 393 LDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLT 452 L + A + GE V+ E A GNG +DA+ A+ V + Y Sbjct: 445 LVELTGTDARGSHRVRATVVWQGETVEIEGA-GNGRLDALCHALEEGLGIRVANLTYKEH 503 Query: 453 AKGHGKDALGQVDIVANY-NGRRFHGVGLATDIVESSAKAMVHVLNNIWRAA 503 A G + I + G G G+ TDI+E+SAKA+V +N + Sbjct: 504 ALEVGSGSRAVAYISVDDEEGNTHFGCGVDTDIMEASAKALVSAVNRMLAHR 555 >UniRef50_B3PEP5 2-isopropylmalate synthase n=90 Tax=Bacteria RepID=B3PEP5_CELJU Length = 673 Score = 376 bits (965), Expect = e-102, Method: Composition-based stats. Identities = 121/527 (22%), Positives = 220/527 (41%), Gaps = 36/527 (6%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + I T LRDG QAL +SV+ KL++ L +G +E+GFP +S D+ + + Sbjct: 147 KPPIWMSTDLRDGNQALIDPMSVQTKLRMFKELVAIGFKEIEIGFPSASEIDYNFTRMLI 206 Query: 63 RQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + + + L + I+ +SL+ A +H + +P + + V Sbjct: 207 EENLIPDDVTIEVLVQARYDLIEKTVQSLRGARRAILHMYNPLAPAFRKIVYNTDKEGVK 266 Query: 120 ERAIYMVKRARNYT-------DDVEFSCEDAGRTPIADLARVVEAAINAGAT------TI 166 + A+ + + T ++S E T I + V +A + + Sbjct: 267 KIALQGTQWCKELTAQAPEVDWTFQYSPEVFSSTEIEFVKEVCDAVVEIWNPSPQKKIIL 326 Query: 167 NIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVE 226 N+P TV P +A I ++ + D +ISVH H+D G AV + AV AGA +VE Sbjct: 327 NLPATVEMNTPNTYADQIEWIHRNIHRRDSIVISVHPHNDRGTAVAAAELAVMAGADRVE 386 Query: 227 GAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKA 286 G + G GER GN L + + + + VH ++ +I + +L + +P+ Sbjct: 387 GCLFGNGERTGNVDLVTLALNLYSQG----VHPGLDFSDIDKVRKLHEECTQLPVHPRHP 442 Query: 287 IVGSGAFAHSSGIHQDGVLKNRE----------NYEIMTPESIGLNQIQLN-LTSRSGRA 335 G F SG HQD + K Y + P + + + + ++SG+ Sbjct: 443 YAGELVFTAFSGSHQDAIKKGFAVQKKDTLWEVPYLPIDPADLNRSYDAVVRVNAQSGKG 502 Query: 336 AVKHRM-DEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQ--QEEPEHFR 392 V + E G + K++D G+ A F + P ++ Sbjct: 503 GVSFLLQQEAGLQLPRRLQIEFSSVVQKVSDSTGKEVKASDIARIFNEEYFAVNSPITYQ 562 Query: 393 LDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLT 452 F+ Q ++ + + V+ + +GNGP+DA AI++ + V ++ Y Sbjct: 563 SSKFTEQDDTHQVDIVIHAQHQNKTVEI-SGSGNGPIDAAAHAISQFIDTEVNVIDYHEH 621 Query: 453 AKGHGKDALGQVDIVANY-NGRRFHGVGLATDIVESSAKAMVHVLNN 498 + G G D + + NG+ +GVG +I+ S+ KA+++ +N Sbjct: 622 SVGEGSDVVAVTYVEIKVKNGKPVYGVGQDRNIITSAVKALINGVNR 668 >UniRef50_C6VV54 Pyruvate carboxyltransferase n=32 Tax=Bacteria RepID=C6VV54_DYAFD Length = 520 Score = 373 bits (959), Expect = e-102, Method: Composition-based stats. Identities = 144/509 (28%), Positives = 228/509 (44%), Gaps = 17/509 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIAL-ALERMGVDVMEVGFPVSSPGDFESVQT 60 S+ + I DTTLRDGEQ S S EKL IA L+ + VD +EV S G+F++V+ Sbjct: 3 SRYIEIMDTTLRDGEQTSGVSFSASEKLTIAQILLQEVKVDRIEVASARVSEGEFQAVKK 62 Query: 61 IARQVK-NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 I N + + D D + + A A ++ S H+ +L+ + + Sbjct: 63 ITDWAGANGFLDKIEVLTFVDGDASINWMVQAGARVMNLLTKGSLNHLTHQLKKSPEAHF 122 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTVGYTM 176 E +V+ A ED R+ + + ++ I +PDT+G Sbjct: 123 EDIRNVVELAEKNGIQCNVYLEDWSNGMRSSKEYVFQSLDFLSTLPVKRILLPDTLGILT 182 Query: 177 PFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERA 236 PFE I + +R P+ H H+D L V N + A+ AG + + +NG+GER Sbjct: 183 PFESYTFIKEIVDRYPDQ---HFEFHGHNDYDLGVANVMEALRAGVQGLHLTVNGMGERT 239 Query: 237 GNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHS 296 GN L I I TA+N + ++ S+LV + IPANK IVG F + Sbjct: 240 GNAPLASTIAVINDLM--PECTTAVNEKSLYSISKLVETFSGIRIPANKPIVGESVFTQT 297 Query: 297 SGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNL 356 +GIH DG KN + + PE G ++ L SG+A +++ + ++G S+ +L + Sbjct: 298 AGIHADGDKKNNLYFSKLMPERFGRQRL-YALGKTSGKANIENNLRDLGISLSDADLKKV 356 Query: 357 YDAFLKLADKKGQVFDYDLEALA-FIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACG 415 ++L D+K V DL + I E + + + N +A ++++ G Sbjct: 357 TQRIIELGDRKEVVTPEDLPYIISDILDSDAIEEKVVITNYVLTHSKNLKPSATLQISFG 416 Query: 416 EEVKAEAANGNGPVDAVYQAINRITEYN----VELVKYSLTAKGHG-KDALGQVDIVANY 470 EEV E A G+G DA A+ +I + L Y++ G DAL + I Sbjct: 417 EEVFEENAQGDGQYDAFMNALKKIYKKKGIELPMLSDYTVRIPPGGKTDALCETIITWEI 476 Query: 471 NGRRFHGVGLATDIVESSAKAMVHVLNNI 499 NG+ GL +D S+ KA +LN I Sbjct: 477 NGKEIKTRGLDSDQTFSAIKATQKMLNLI 505 >UniRef50_A6C4F8 2-isopropylmalate synthase n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C4F8_9PLAN Length = 406 Score = 373 bits (958), Expect = e-101, Method: Composition-based stats. Identities = 143/364 (39%), Positives = 210/364 (57%), Gaps = 2/364 (0%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 + V+ DTTLRDGEQ A+L EKLQIA ALE GV ++ GFP SS D +++Q++ Sbjct: 27 TGAVLFSDTTLRDGEQMPGATLDPIEKLQIAKALEAAGVHSLDAGFPASSQADIDAIQSM 86 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVA--EAFRIHTFIATSPMHIATKLRSTLDEVI 119 +K + AL R + D+D A E+L + F TSP+H KL + EV+ Sbjct: 87 VGVIKKPVLTALCRTLPGDVDAADEALAGNPPHKRGVSLFCGTSPLHRQFKLEKSKSEVL 146 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE 179 + + ++ A D V FS EDA RT + L V AI AGATTI PDTVG P++ Sbjct: 147 KLIVDSIQYAAEKFDIVAFSPEDASRTEVDFLCEVYREAIAAGATTIGFPDTVGILTPWK 206 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 I + + VP I+ +++VH H+DLGLAV N+LA + AGA V+ +NGIGERAGN Sbjct: 207 AQDFICRIQDEVPGIENVLLAVHFHNDLGLAVANTLACIDAGANVVQCTVNGIGERAGNA 266 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 +LEEV MA+ + ++ ++ ++ +LV+++ + + K + GS FA +GI Sbjct: 267 ALEEVAMALHLHQEEYQRPHQLDVSQLAPLCKLVAELTGIALSPMKPVAGSNIFATEAGI 326 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 HQDG+LKN + Y PE++G I+L L SGR A+ HR+ E+G + +E + + A Sbjct: 327 HQDGLLKNPDTYLPYRPETVGETGIRLVLGRHSGRKAILHRLHELGKEPNEQVVQRVLQA 386 Query: 360 FLKL 363 +L Sbjct: 387 IKEL 390 >UniRef50_D1AJT6 2-isopropylmalate synthase/homocitrate synthase family protein n=4 Tax=Bacteria RepID=D1AJT6_SEBTE Length = 529 Score = 372 bits (955), Expect = e-101, Method: Composition-based stats. Identities = 141/527 (26%), Positives = 249/527 (47%), Gaps = 30/527 (5%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 +V +FDTTLRDG QA S SVK+K+ + AL+ G+D +E G P S+P D E + + Sbjct: 3 KVEVFDTTLRDGAQARGISFSVKDKIAVTQALDAFGIDYIEAGNPGSNPKDLEFFELVKS 62 Query: 64 -QVKNSRVCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEV 118 ++K+S++ A KD+ D SL A + F + H+ +++TL+ Sbjct: 63 VELKHSKLVAFGSTRRKDVAPEEDQNLISLLQAGTEYVSIFGKSWDFHVTDIIKTTLENN 122 Query: 119 IERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGYT 175 +E + ++ V F E D + ++AA + GA + + DT G Sbjct: 123 LEMIKDTLLFLKSKGKKVIFDAEHFFDGYKNNPEYALEALKAAKDGGAEILTLCDTNGGC 182 Query: 176 MPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGER 235 P E + I + E++ I +H H+D+G V NS+AAV AGA QV+G G GER Sbjct: 183 FPEEISRITKEVKEKL---GDIKIGIHAHNDMGFGVANSIAAVEAGALQVQGTFLGYGER 239 Query: 236 AGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAH 295 GN +L +I ++++KD V + T++++++I N+ I + +G AFAH Sbjct: 240 CGNANLSTIIANLQLKKDYELV-PREKLGLLTSTARIIAEISNITIEDSMPYIGKNAFAH 298 Query: 296 SSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE--SEYNL 353 G+H DGV K ++E + PE +G + + L+ SGR+ + + + Sbjct: 299 KGGMHIDGVSKASHSFEHINPELVGNER-EFLLSEVSGRSTILEEIRRVDKDIQRDSEAT 357 Query: 354 DNLYDAFLKLADKKGQVFDYDLEALAFIGKQQ--EEPEHFRLDYFSVQS---GSNDIATA 408 + + +L + +G F+ + ++ + F L YF V+ G +TA Sbjct: 358 AGIIERLKEL-EYQGYQFEGAKATFELVIRKYLGKYKPFFDLVYFDVKGNYIGKKYYSTA 416 Query: 409 AVKLACGEEVKAEAANGNGPVDAVYQAINRITEY------NVELVKYSLTAKGH---GKD 459 VK+ ++++ A G+GPV+A+ QA+ E + L+ Y + Sbjct: 417 VVKVKVKDQIELTVAEGDGPVNALDQALRIALERFYPELKEMHLIDYKVRVLKGEENATA 476 Query: 460 ALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVE 506 + +V I + + +G++TDI+E+S A+V + ++ Sbjct: 477 SKVRVLIESADAKNSWTTIGVSTDIIEASWIALVDSIEYKLIQETLK 523 >UniRef50_A1KBD3 2-isopropylmalate synthase n=14 Tax=Bacteria RepID=LEU1_AZOSB Length = 572 Score = 371 bits (952), Expect = e-101, Method: Composition-based stats. Identities = 126/534 (23%), Positives = 214/534 (40%), Gaps = 39/534 (7%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +++ + T LRDG QAL ++ + K+++ L +G+ +EV FP +S DF+ V+ Sbjct: 35 ITRPPVWMSTDLRDGNQALFEPMNSERKMRMFKMLVEIGLKEIEVAFPAASQTDFDFVRE 94 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + + L + I+ ES++ A+ +H + A +P + Sbjct: 95 LIEGGHIPDDVTIEVLTQARPHLIERTFESVRGAKRAIVHVYNAVAPNFRRIVFDTDRAG 154 Query: 118 VIERAIYMVKR-----ARNYTDDVEF--SCEDAGRTPIADLARVVEAAINAGATT----- 165 V + A+ + AR D F S E T + V A I T Sbjct: 155 VKQIAVDSARYFVEMAARQPGTDFTFQYSPEVFSGTELDFAVEVANAVIEVWQPTPQQKC 214 Query: 166 -INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 IN+P TV + P +A I ++ + D ++SVH H+D G AV + AV AGA + Sbjct: 215 IINLPATVEMSTPNVYADQIEWMHRHLARRDSVLLSVHPHNDRGTAVAAAELAVMAGADR 274 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 VEG + G GER GN L + + + + VH ++ I ++ V +PI Sbjct: 275 VEGCLFGNGERTGNVDLVTLALNLYSQG----VHPGLDFSRINEVARTVEHCTQLPIHPR 330 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNRE----------NYEIMTPESIGLN-QIQLNLTSRSG 333 VG F SG HQD + K Y + P +G + + + + S+SG Sbjct: 331 HPYVGDLVFTAFSGSHQDAIKKGFAVQQPDAVWEVPYLPVDPADLGRSYESIIRVNSQSG 390 Query: 334 RAAVKHRMD-EMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFR 392 + + + ++ E G A ++ D++G AF + + Sbjct: 391 KGGIAYLLEAEYGLVMPRRLQVEFSAAIQRITDERGTELSAGDIWRAFEEEYLAVAAPYA 450 Query: 393 LDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLT 452 + ++ + + GNGP+DA A+ + L+ Y Sbjct: 451 YVE-HHLAEHGGQQGISLTVEEAGVRRVLRGVGNGPIDAALHAL----DAGAVLLGYEER 505 Query: 453 AKGHGKDALGQVDIVANY--NGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAE 504 A G G DA I G GVG+ +IV +S A+V L+ + + E Sbjct: 506 AIGQGGDARAVAYIELADGEGGGSTFGVGIHANIVTASVLAIVSALDRLAQRRE 559 >UniRef50_B1MVR2 2-isopropylmalate synthase n=1 Tax=Leuconostoc citreum KM20 RepID=B1MVR2_LEUCK Length = 398 Score = 370 bits (951), Expect = e-101, Method: Composition-based stats. Identities = 158/387 (40%), Positives = 235/387 (60%), Gaps = 1/387 (0%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+ Q+ +D T+RDGEQ + + ++ EK+++A ALE+ GV +E GFP +S DF++V Sbjct: 7 MTNQITFYDPTMRDGEQTIGVNFTIDEKIKLAQALEKYGVSAIEAGFPAASKKDFDAVVE 66 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I++ V ++V LAR V +DID + + A+ IH FIATSP+H KL + E+IE Sbjct: 67 ISKVVHTAKVVGLARLVRQDIDAVVAATQQAKHPMIHVFIATSPVHRTYKLHMSPSEIIE 126 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 + I ++ + ++ FS EDA RT LARV++AAI +GAT INIPDTVGY P+E+ Sbjct: 127 KVISDIRYTKTMMSEIIFSPEDATRTEPEFLARVIQAAIESGATMINIPDTVGYATPYEY 186 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 + L E V + D+ + HTH+DLG+A N+LA + GA +++G +NGIGERAGN Sbjct: 187 GELFEYLREHVRDFDQVTWATHTHNDLGMANANALAGIMHGATEIQGTINGIGERAGNVD 246 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 + E AI VR+ TAI ++ S +V+Q +MP+ NK I+G AFAH SGIH Sbjct: 247 IIEAAAAIYVRRQTFAKQTAIILEQSKHISDIVAQATHMPVAKNKPIMGRNAFAHESGIH 306 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 QDG LKN E YEI+ PE +G Q L L SG AV +++ +GY S ++ + F Sbjct: 307 QDGYLKNPETYEILRPEMVG-TQASLPLGKLSGSHAVMNQLLSLGYHISRQDMVTILPIF 365 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEE 387 ++A+K V D ++ + + + + Sbjct: 366 KRIAEKTSTVSDQQMQDMMTMIQTNKM 392 >UniRef50_B1L4G2 Pyruvate carboxyltransferase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L4G2_KORCO Length = 495 Score = 370 bits (949), Expect = e-100, Method: Composition-based stats. Identities = 148/507 (29%), Positives = 250/507 (49%), Gaps = 22/507 (4%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPG-------DFES 57 + IFD+TL GE S ++ KL+IA L+ +GVDV+E GFP SS G + Sbjct: 2 IRIFDSTLTLGEMVPGVSFGLEGKLEIASHLDTLGVDVIEAGFPASSEGEKRVVREVVRN 61 Query: 58 VQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 V+ ++R + VCALAR + +D+ A E+ ++ FI S + + +E Sbjct: 62 VKRLSRSGLSPEVCALARAIREDVKAAVET----GVDSVNIFIPASRLLLERAYGMREEE 117 Query: 118 VIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMP 177 ER V A+++ VEF+ EDAGR+ L + A +GA IN+ D VG +P Sbjct: 118 ARERVREAVSLAKSHDLTVEFTAEDAGRSD-DLLWDLCRIAEESGADRINLSDPVGAMLP 176 Query: 178 FEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 + I+ +R+ ISV +DLG+A NSL+A AGA Q+ ++NG+G +AG Sbjct: 177 DDAKKIVLEAKKRIRK----PISVTFSNDLGMATANSLSAAIAGADQIHVSVNGLGPKAG 232 Query: 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 LE+V++ +K + T + + + S+ V +I +PI IVG F + + Sbjct: 233 IAPLEQVVVGLKKLAGL---DTNVKMELLPSVSEAVERISGIPISEISPIVGPLVFTYEA 289 Query: 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 G+H + +YEI++P +G + + + + SGR AVK + EMGY S+ +++ + Sbjct: 290 GVHVSAISNELSSYEIVSPGEVGRVR-RFWVGTHSGRKAVKEVLKEMGYSASDSDVERIL 348 Query: 358 DAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEE 417 +L+ + ++ + ++ E P F++ + +GS TA ++ G Sbjct: 349 ARVKELSQEGIRITEAIFRSVVEEVLG-ERPRLFKVKEWVAVTGSGITPTATIRALIGGR 407 Query: 418 VKAEAANGNGPVDAVYQAINRITEYN-VELVKYSLTAKGHGKDALGQVDIVANYNGRRFH 476 +++G GPVDA+ +AI I L ++ L A G +A+ ++ I Sbjct: 408 EVISSSSGVGPVDAITKAIRSIQGIPSFNLRRFRLIAVSSGSEAIAELKIRVVGPKGEVE 467 Query: 477 GVGLATDIVESSAKAMVHVLNNIWRAA 503 G + DIV++S KA+ +N I Sbjct: 468 AAGTSRDIVDASLKAIEEAVNKIIPRE 494 >UniRef50_C9RN88 2-isopropylmalate synthase/homocitrate synthase family protein n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RN88_FIBSS Length = 535 Score = 367 bits (942), Expect = e-100, Method: Composition-based stats. Identities = 137/526 (26%), Positives = 247/526 (46%), Gaps = 32/526 (6%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPV-SSPGDFESVQTIA 62 +V+++DTTLRDG Q + SLS+ +K+QIA L+ G D +E G+P S+P D E + I Sbjct: 2 KVLLYDTTLRDGNQDRKISLSLADKVQIARILDHFGFDYIEGGWPNPSNPTDEEFFKLIK 61 Query: 63 R-QVKNSRVCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 ++K++++ A I D ++L +EA F + +H+ +R+TL+E Sbjct: 62 DVKLKHAKIAAFGSTRRPGILPENDPLLQALIKSEAPVKTIFGKSWDLHVTDVIRTTLEE 121 Query: 118 VIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGY 174 ++ V + ++++V + E D + ++AA A I + DT G Sbjct: 122 NLDMIESSVAYLKEHSEEVIYDAEHFFDGYKANPEYALETLKAAELGHADCIVLCDTNGG 181 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 TMP+E I+ + R+ + +H H+D GLAV NS+ AV AG V+G +NG GE Sbjct: 182 TMPWEIEEIVKKVQTRI----STPLGIHVHNDSGLAVANSIYAVKAGCVMVQGVVNGYGE 237 Query: 235 RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFA 294 R GN +L + +K + D + + S + QI N+P + VG AFA Sbjct: 238 RCGNANLTTIAADLKFKMDRDFAAAK-KLSHLRQLSGNIDQIVNLPSDVHAPYVGDAAFA 296 Query: 295 HSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEM--GYKESEYN 352 H G H DGV+K ++E + P S+G ++ + ++G + V ++ + G + + Sbjct: 297 HKGGAHIDGVMKVSRSFEHIDPHSVGNDR-VFVTSDQAGGSLVVEKLKAIKPGIDKKDPV 355 Query: 353 LDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQ--EEPEHFRLDYFSVQSGSND----IA 406 + +L + + G FD + + + E F++ + V ++ Sbjct: 356 VASLLKEIKE-RENAGWHFDSAEASFKLLVYRHLGMVKEPFKVLNYRVIEDKTPQGVSVS 414 Query: 407 TAAVKLACGEEVKAEAANGNGPVDAVYQAINRIT------EYNVELVKYSLTAKGH--GK 458 A VKL G+++ + + G+GPV+A+ A+ + +V L + + G Sbjct: 415 QATVKLQVGDKISHQVSEGDGPVNALDAALRKALLPFFPCMGSVRLDDFKVRVLGSNVAS 474 Query: 459 DALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAE 504 DA +V ++ VG++++I+E+ A V L + Sbjct: 475 DATVRVWTTFGDEHGYWNMVGVSSNIIEACWTAFVDGLTYKILLED 520 >UniRef50_Q04TA5 2-isopropylmalate/homocitrate synthase n=14 Tax=Bacteria RepID=Q04TA5_LEPBJ Length = 516 Score = 367 bits (941), Expect = e-100, Method: Composition-based stats. Identities = 136/528 (25%), Positives = 224/528 (42%), Gaps = 35/528 (6%) Query: 1 MSQ---QVIIFDTTLRDGEQALQASLSVKEKLQIAL-ALERMGVDVMEVGFPVSSPGDFE 56 M++ ++ I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E Sbjct: 1 MTKAETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 Query: 57 SVQTIA------RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATK 110 +VQ I + + + D + + +K + A ++ S H+ + Sbjct: 61 TVQKIIEWAETEQLTERIEILGFV-----DGNKTVDWIKDSGARVLNLLTKGSLHHLEKQ 115 Query: 111 LRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTIN 167 L T E +++ A + ED R + +V+ I Sbjct: 116 LNKTPKEFFADVSIVIEYAIKNGLKINVYLEDWSNGFRNSPDYVEALVKHLSKERIERIF 175 Query: 168 IPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEG 227 +PDT+G P E + L ++ PN+ H H+D L+V NSL A+ AG + + Sbjct: 176 LPDTLGVLSPEETFQGVDSLVQKYPNL---HFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 Query: 228 AMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAI 287 +MNG+GERAGN LE ++ I D T IN I S+LV I AN+ I Sbjct: 233 SMNGLGERAGNTPLEALVTTIH---DKSQAKTNINELAITEASRLVEVFSGKRISANRPI 289 Query: 288 VGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK 347 VG F ++G+H DG K + PE G + L SG+A++ + ++G Sbjct: 290 VGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLSGKASISENVKQLGMV 348 Query: 348 ESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIAT 407 S+ L + + ++L D+ V DL + + + + ++ SG Sbjct: 349 LSDIVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGVRPH 408 Query: 408 AAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYN----VELVKYSLTAKGHG-KDALG 462 A ++L +V E + G+G DA A+ +IT +L+ Y + G DAL Sbjct: 409 AQIELEYQGKVHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALV 468 Query: 463 QVDIVAN-----YNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 + I N + F +G+ D ++ A +LN I + + Sbjct: 469 ETMITWNKSLDLEEDQTFKTMGVHPDQTIAAVHATEKMLNQILQPWQT 516 >UniRef50_B2AHM5 2-isopropylmalate synthase n=69 Tax=cellular organisms RepID=LEU1_CUPTR Length = 569 Score = 366 bits (940), Expect = 1e-99, Method: Composition-based stats. Identities = 119/532 (22%), Positives = 207/532 (38%), Gaps = 37/532 (6%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +++ T LRDG QAL ++ KL++ L ++G+ +EV FP +S DF+ V+ Sbjct: 27 ITRAPRWMSTDLRDGNQALIEPMNPARKLRLFEQLVKIGLKEIEVAFPAASQTDFDFVRM 86 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + + + L + E I ES++ A +H + +P ++ DE Sbjct: 87 LIEERRIPDDVTIVVLTQSREDLIRRTVESVRGAARATVHLYNPIAPAWRRIVFNASRDE 146 Query: 118 VIERAIYMVKRARNYT-------DDVEFSCEDAGRTPIADLARVVEAAINAG------AT 164 + A+ + + T E+S E + V +A A Sbjct: 147 IKAVAVSGTRLIKALTDAMPETAWTYEYSPETFSLAELDFSLEVSDAVSAAWQAGPGRPM 206 Query: 165 TINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 +N+P TV + P FA I ++ R+ ++SVH H+D G AV + A+ AGA + Sbjct: 207 ILNLPTTVECSTPNVFADQIEWMHRRLARRAHIVLSVHPHNDRGTAVAAAELALMAGADR 266 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 VEG + G GER GN L + + + + V ++ +I Q V +P+ Sbjct: 267 VEGCLFGNGERTGNVDLVTLALNLYTQG----VAPELDFSDIDAVRQCVEHCNQLPVHPR 322 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNRE----------NYEIMTPESIGLNQ-IQLNLTSRSG 333 VG F SG HQD + K Y + P +G + + + S+SG Sbjct: 323 HPYVGDLVFTAFSGSHQDAIRKGFAQQQPDAIWEVPYLPIDPADLGRSYDAVIRVNSQSG 382 Query: 334 RAAVKHRMDE-MGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFR 392 + + + +++ G A + D G D F + R Sbjct: 383 KGGMAYLLEQVHGLYLPRRLQIEFSRAVQAMTDDTGLEASADDLYGLFRREYLARETPLR 442 Query: 393 LDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLT 452 + S + V++ + GNGP+DA A+ + V ++ Y Sbjct: 443 YVSHQLASDATGATAITVQMERDGQPCTVRGTGNGPIDAFIDAL----DLPVRVMDYHEH 498 Query: 453 AKGHGKDALGQVDIVANYNGR-RFHGVGLATDIVESSAKAMVHVLNNIWRAA 503 A G DA + G G+ +V +S +A+V +N +A Sbjct: 499 AMTAGADARAACYVEVRVGDSPTGFGAGIDASLVTASLRAVVSGVNRHLQAG 550 >UniRef50_B2UP78 2-isopropylmalate synthase/homocitrate synthase family protein n=2 Tax=Bacteria RepID=B2UP78_AKKM8 Length = 544 Score = 366 bits (939), Expect = 1e-99, Method: Composition-based stats. Identities = 141/551 (25%), Positives = 254/551 (46%), Gaps = 43/551 (7%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 MS ++ ++DTTLRDG Q+ +LS +K++IA L+ +G+D +E G+P ++P + E Sbjct: 1 MSTKIFLYDTTLRDGAQSEDVNLSATDKVRIARQLDYLGMDYIEGGWPGANPVETEFFNA 60 Query: 61 IARQV-KNSRVCALA----RCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + +N+++ A + D +L + A F + P H+ L + Sbjct: 61 MRGVGLRNAKLAAFGSTHHPSHTPETDPTLTALISSGARVAAVFGKSCPRHVEVALGISR 120 Query: 116 DEVIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTV 172 + +E + + ++ F E D + V+ A GA + + DT Sbjct: 121 ERNLEIIGNSISFLKKNMEEAFFDAEHFFDGFKRDQEYALAVLRTAWEHGADCLVLCDTN 180 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G TMP E + II + ER+P+ A++ +H H+D LAV NSLAAV++GA QV+G +NGI Sbjct: 181 GGTMPEEISSIIRTVRERLPH---ALLGIHAHNDCELAVANSLAAVNSGAIQVQGTVNGI 237 Query: 233 GERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 GER GN +L VI ++V+ + + + + T+ VS++ N+ + VG+ A Sbjct: 238 GERCGNANLCSVIPNLQVKMKGFSCLSGASLTRLKSTAAFVSEVSNLAPFRRQPFVGNAA 297 Query: 293 FAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKES--E 350 FAH G+H ++K YE + P +G N ++ +T + GR+ + +G++ + Sbjct: 298 FAHKGGVHVSAIMKEAALYEHIDPSLVG-NAQRVLMTEQGGRSNILSLSRTLGFELEKGD 356 Query: 351 YNLDNLYDAFLKLA----DKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQS----GS 402 LD L A K A D +L L + +P L + S Sbjct: 357 PLLDVLSAAVKKNAALGYDYVAAPASAELLFLRHMPDNALKPYFNILRTVVLTSRHEMDP 416 Query: 403 NDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEY------NVELVKYSLTAKG- 455 + + A++KL V+ AA G GPV A+ +A+ R + L+ Y + Sbjct: 417 DMMVEASLKLDVHGNVEHTAAGGFGPVHALDRALRRALTRWYPELEQMHLIDYKVRVLSP 476 Query: 456 -----------HGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAE 504 +G + +V I ++ + VG++ +I+E+S +A+ + Sbjct: 477 TRTNIPEAEDENGTGSNVRVLIESSDGVATWTTVGVSYNIIEASLEALADAVTYKLYK-- 534 Query: 505 VEKELQRKAQH 515 ++ + +A+ Sbjct: 535 -TEQARWRAEC 544 >UniRef50_D2QST1 Pyruvate carboxyltransferase n=1 Tax=Spirosoma linguale DSM 74 RepID=D2QST1_9SPHI Length = 506 Score = 365 bits (938), Expect = 2e-99, Method: Composition-based stats. Identities = 134/516 (25%), Positives = 221/516 (42%), Gaps = 28/516 (5%) Query: 1 MSQQ-VIIFDTTLRDGEQALQASLSVKEKLQIALAL-ERMGVDVMEVGFPVSSPGDFESV 58 M ++ + I DTTLRDGEQ S S EKL +A L + VD +E+ S G+ E+V Sbjct: 1 MKRRYIEIMDTTLRDGEQTSGVSFSASEKLALAQLLLTEVKVDRVEIASARVSAGELEAV 60 Query: 59 QTIAR------QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLR 112 Q I R + V D + + L+ + A ++ S H+ +L+ Sbjct: 61 QQITRWADSIGLIDKVEVLTFV-----DGQASLDWLQASGAKVMNLLTKGSLNHLTHQLK 115 Query: 113 STLDEVIERAIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIP 169 T E +V A ED R + + ++ + +P Sbjct: 116 KTPGEHFTDIGQVVCAAGKLGVKANVYLEDWSNGMRNSPDYVFQYLDFLNTQPILRVLLP 175 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G P E + L R PN+ H H+D L++ N + A+ AGA + + Sbjct: 176 DTLGVLTPAESYSFVHQLVTRYPNL---HFDFHAHNDYDLSIANVMEAIRAGAHGIHLTV 232 Query: 230 NGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVG 289 NG+GERAGN L I ++ V T + + +++ S++V + IP NK +VG Sbjct: 233 NGLGERAGNAPLASAIAVLRDFM--PEVRTGVVEKSLYQVSKIVETFSGLRIPDNKPVVG 290 Query: 290 SGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKES 349 F ++GIH DG KN + + PE G + L SG+A +++ + E+G + S Sbjct: 291 DNVFTQTAGIHADGDKKNNLYFNALLPERFGRKRS-YALGKMSGKANIENNLRELGIQLS 349 Query: 350 EYNLDNLYDAFLKLADKKGQVFDYDLEALA-FIGKQQEEPEHFRLDYFSVQSGSNDIATA 408 E +L + ++L D+K V DL + + + + + + +A Sbjct: 350 EDDLKKVTQRVIELGDQKEVVTREDLPYVISDVLNTNSFASRVEVLNYVLTHSKDLKPSA 409 Query: 409 AVKLACGEEVKAEAANGNGPVDAVYQAINRITEYN----VELVKYSLTAKGHG-KDALGQ 463 +++ EE E+A G+G DA A+ +I L Y++ G DAL + Sbjct: 410 TLRVRIDEEHFEESAQGDGQYDAFMNALKKIYVKKKLTLPLLTDYAVRIPTGGRTDALCE 469 Query: 464 VDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNI 499 I + F GL +D S+ KA +LN + Sbjct: 470 TIITWKHKNGEFKTRGLDSDQTVSAIKATQKMLNTL 505 >UniRef50_UPI000038E0F9 2-isopropylmalate synthase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0F9 Length = 388 Score = 364 bits (935), Expect = 4e-99, Method: Composition-based stats. Identities = 132/360 (36%), Positives = 205/360 (56%), Gaps = 17/360 (4%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + + IFDTTLRDGEQ S + +K +IA L GV+++E GFP S + +S++ I Sbjct: 28 ENISIFDTTLRDGEQTPGVSFNTDQKYKIAKMLYDAGVNIIEAGFPAVSNDEMKSIKKIN 87 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 ++N +C+LARC DID ES ++ IH FIATS +H+ KL+ T ++V + Sbjct: 88 HDMEN--ICSLARCNRNDIDKVIES----DSRIIHLFIATSDIHMKYKLKKTREQVFDSI 141 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + + AR+Y + FS EDA RT + L ++ + TIN PDT+G P Sbjct: 142 MESIDYARSYGMRIIFSPEDATRTSMDFLKQI---VSSIKVETINFPDTIGIMNPISMYY 198 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I+ + + IS+H H+D G+A N+LA + AGA + + +NGIGERAGN SLE Sbjct: 199 FINKIK----SFTSTGISIHCHNDFGMATANTLAGLMAGANEAQVTVNGIGERAGNASLE 254 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV+ +I LN +T I ++++ S+ VS + NKAI G AF+H +GIH Sbjct: 255 EVVSSI---YGFLNSYTDIKMEKLYSISKYVSAASGIIPQKNKAITGENAFSHEAGIHVQ 311 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G++ N + YE + PE GLN+ ++ + SG+AA+K+ ++ G +++ +DN+ K Sbjct: 312 GIINNPKTYEAINPEIFGLNR-RIVIGKHSGKAAIKYILENNGMHKTDDEIDNILQIVKK 370 >UniRef50_Q0EZI5 2-isopropylmalate synthase n=1 Tax=Mariprofundus ferrooxydans PV-1 RepID=Q0EZI5_9PROT Length = 543 Score = 364 bits (934), Expect = 6e-99, Method: Composition-based stats. Identities = 128/533 (24%), Positives = 248/533 (46%), Gaps = 30/533 (5%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ ++DTTLRDG Q+ S ++K +IA L G+D +E G+P +SP D + + Sbjct: 8 RRIQLYDTTLRDGAQSAGIHFSAEDKKRIARRLASFGMDWIEGGWPGASPTDDCFFELMR 67 Query: 63 RQV-KNSRVCALA----RCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + +SR+ A D L A + F + +H+ T L L Sbjct: 68 DRAWSHSRLVAFGSTARPGHPASEDPGLARLVACGADAVCIFGKSWDLHVTTGLGIDLQT 127 Query: 118 VIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGY 174 ++ V + + D V F E D +V+ AA +AGA ++ + DT G Sbjct: 128 NLDLVRESVAWLKLHVDTVLFDAEHFFDGYAANRDYAMQVLAAAADAGADSLVLCDTNGG 187 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 ++P + + + R P++ I +H H+D +AV N+++AV AGA V+G +NG+GE Sbjct: 188 SLPEQIGACVRQVVARYPDLT---IGIHAHNDSEMAVANAVSAVSAGASHVQGTINGLGE 244 Query: 235 RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFA 294 R GN +L VI +K++ + + + +++ R S V+++ N ++ VG AFA Sbjct: 245 RCGNTNLISVIPVLKLKMGVNCGVSTESLRKLRRLSTFVNEMANQLPWQHQPFVGQNAFA 304 Query: 295 HSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYK--ESEYN 352 H GIH V K YE + P S+G N ++ +++++GR+ + ++ ++ + Sbjct: 305 HKGGIHVSAVRKASHLYEHIDPASVG-NAQRVLVSNQAGRSNILAKLQQLEPDAIVDDAA 363 Query: 353 LDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQ--EEPEHFRLDYFSVQSGSNDI----- 405 + ++ + G F+ + + ++ + HF L F V Sbjct: 364 VVRAVQRIKEM-EATGYAFEGADASFQLLLRRATGQFRRHFELVSFRVYDEKRGHDEAPE 422 Query: 406 ATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITE------YNVELVKYSLTAKGH--G 457 + A V++ + AA G+GPV+A+ +A+ ++ L + + Sbjct: 423 SEATVQVRVNGRLLHTAALGSGPVNAMDKALRAALTGAYPGLEDMRLTDFKVRVLSTKDA 482 Query: 458 KDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQ 510 +A +V I ++ R+++ VG++TD++E++ +A+ + +V E + Sbjct: 483 TEAAVRVLIESSDGVRKWNTVGVSTDVLEATYRALNDAIEYKLVMDQVASEGE 535 >UniRef50_Q6L0K4 2-isopropylmalate synthase n=1 Tax=Picrophilus torridus RepID=Q6L0K4_PICTO Length = 386 Score = 363 bits (933), Expect = 6e-99, Method: Composition-based stats. Identities = 138/364 (37%), Positives = 208/364 (57%), Gaps = 14/364 (3%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ IFDTTLRDGEQ+ S ++ +K +IA L +GVD++E GF S + +++ I Sbjct: 27 KRIRIFDTTLRDGEQSPGVSFNINQKARIAGMLVDLGVDMIETGFAAVSSEESMAIRKIH 86 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 N +LARC DID ++ IH FIATS +HI KL+++ + ++E+ Sbjct: 87 EMDGN--FISLARCNRHDIDSVIDT----GIDNIHLFIATSDIHIKYKLKTSRENIMEKI 140 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + + AR++ +V FS EDA RT + L V+ AI++GA INIPDT+G P Sbjct: 141 VDSIDYARSHGLNVLFSPEDATRTDMNFLIDVINTAISSGAYEINIPDTIGIMNPISMYN 200 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I + R K+ ISVH H+D G+A N+LAA+ AGA + +NGIGERAGN +LE Sbjct: 201 FIHEIKNR----TKSCISVHCHNDFGMATANTLAAIMAGADGAQVTVNGIGERAGNAALE 256 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV++++ D T IN + I + S+ VS M I NKAIVG AF+H SGIH Sbjct: 257 EVVLSVHAFTD---CSTGINMRMIPKISKYVSMASKMYIQKNKAIVGENAFSHESGIHVH 313 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G++ N E YE + P +GLN+ ++ L SG ++K+ ++ G K+S+ + + Sbjct: 314 GLINNPETYEPIDPGILGLNR-RIVLGKHSGTTSLKYILESHGIKKSDDEISGILVRIKD 372 Query: 363 LADK 366 + Sbjct: 373 MNIY 376 >UniRef50_B8FYI5 Pyruvate carboxyltransferase n=5 Tax=Bacteria RepID=B8FYI5_DESHD Length = 557 Score = 362 bits (930), Expect = 1e-98, Method: Composition-based stats. Identities = 110/532 (20%), Positives = 217/532 (40%), Gaps = 37/532 (6%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 ++ LRDG QAL +S++EKL+ L ++G +EVGFP +S ++ ++T Sbjct: 27 ITTPPTWCSVDLRDGNQALVVPMSLEEKLEYYHMLLKIGFKEIEVGFPAASETEYAFLRT 86 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + Q ++ + L + + I+ ++L + +H + +TS + + +E Sbjct: 87 LIEQNLIPEDVTIQVLTQSRDHIIEKTFKALVGVKKAVVHLYNSTSVAQREQVFKMSREE 146 Query: 118 VIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATT------ 165 ++E A+ + + Y + E +S E T + + ++ T Sbjct: 147 IVEIAVSGARLLKKYAAETEGNFQFEYSPESFTGTEMEFALEICNQVLDVFEPTPENKVI 206 Query: 166 INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQV 225 IN+P TV +MP +A I + E + D I+S+H H+D G AV ++ + AG +++ Sbjct: 207 INLPATVSLSMPHVYASQIEYMSEHLKYRDNVILSLHPHNDRGTAVADAELGLLAGGQRI 266 Query: 226 EGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANK 285 EG + G GER GN + + + + V +N + + + M + + Sbjct: 267 EGTLFGNGERTGNVDIVTLALNLFSHG----VDPGLNFASMLEITAKYEALTRMKVHDRQ 322 Query: 286 AIVGSGAFAHSSGIHQDGVLKNRE------------NYEIMTPESIGLNQI--QLNLTSR 331 G FA SG HQD + K + Y ++ P+ IG + + S+ Sbjct: 323 PYGGKLVFAAFSGSHQDAITKGIKWREEHECHYWNVPYLLIDPQDIGREYEGDVIRINSQ 382 Query: 332 SGRAAVKHRMDEMG-YKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEH 390 SG+ + + +++ + ++D + + F + Sbjct: 383 SGKGGIAYMLEQHYALDLPAKMREAFGYKVKNVSDNLHKELMPEEIKDIFFKEYVNIENP 442 Query: 391 FRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYS 450 + F ++D V L E++ + G+G +DA+ A+ + + Y Sbjct: 443 IKFLNFHFL--NHDDFQTTVTLEFKGEIQELSGEGDGRLDAISNALQARLGLSYSNLIYK 500 Query: 451 LTAKGHGKDALGQVDIVA-NYNGRRFHGVGLATDIVESSAKAMVHVLNNIWR 501 A G + + +G G G+ TDI SS KA++ +N + + Sbjct: 501 EHALELGSKSQAVSYVGVTGPDGVIHWGCGIHTDIFTSSVKALISAINTMIK 552 >UniRef50_A5VPL4 2-isopropylmalate synthase/homocitrate synthase family protein n=151 Tax=Bacteria RepID=A5VPL4_BRUO2 Length = 640 Score = 362 bits (930), Expect = 2e-98, Method: Composition-based stats. Identities = 140/532 (26%), Positives = 233/532 (43%), Gaps = 35/532 (6%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ I+DTTLRDG+Q SV++K I LE +GVD +E G+P ++P D + Sbjct: 107 ERIYIYDTTLRDGQQTPGVDFSVEDKKSIVTLLEELGVDYVEGGYPGANPTDTAFFKR-- 164 Query: 63 RQVKNSRVCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEV 118 RQ ++ A + D SL A A + + H+ L T +E Sbjct: 165 RQTARAKFVAFGMTKRAGVSVSNDPGLSSLLQASADAVCFVAKSWDYHVRLALGCTNEEN 224 Query: 119 IERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGYT 175 +E V AR + CE D + +AA +AGA + + DT G T Sbjct: 225 LESITASVTAARMAGREALVDCEHFFDGYKANPEYALACAKAAYSAGARWVVLCDTNGGT 284 Query: 176 MPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGER 235 P E A I+ + VP + +H H+D AV SLAA+ AG R V+G +NGIGER Sbjct: 285 QPLEVAAIVEAVKAVVPGES---LGIHAHNDTEQAVAVSLAAIDAGVRHVQGTLNGIGER 341 Query: 236 AGNCSLEEVIMAIKVRKDI-LNVHTAIN---HQEIWRTSQLVSQICNMPIPANKAIVGSG 291 GN +L +I + ++ I + I R S+ I N P G+ Sbjct: 342 CGNANLVSLIPTLVLKPYWAERFELGIKPASLKSITRISRAFDDILNRPATEQAPYTGTS 401 Query: 292 AFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE--S 349 AFA +GIH ++K + YE + PES+G ++ + + + G++ ++ G + Sbjct: 402 AFATKAGIHASALMKEPQTYEHIPPESVGNSRRVMV-SDQGGKSNFIAELERRGIRVAKD 460 Query: 350 EYNLDNLYDAFLKL-ADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGS------ 402 + LD L + A+ L G +PE F+++ F Sbjct: 461 DVRLDTLIALVKEREAEGYAYEGADASFELLARGMLNPQPEFFKVESFRCLVERRFDANG 520 Query: 403 --NDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITE------YNVELVKYSLTAK 454 ++ A VK+ E+ A G+GPV+A+ A+ + ++ELV + + Sbjct: 521 MLKTVSEAVVKVEVDGEMHMSVAEGHGPVNALDIALRKDLGCFQAEIEDLELVDFKVRIL 580 Query: 455 GHGKDALGQVDIVANYN-GRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 G A+ +V I + G R+ VG++ +I+++S +A++ +N Sbjct: 581 NGGTAAITRVLIESGDATGARWRTVGVSDNIIDASFQALMDSVNYKLMKNRA 632 >UniRef50_D1N7Y9 Pyruvate carboxyltransferase n=2 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N7Y9_9BACT Length = 567 Score = 362 bits (928), Expect = 3e-98, Method: Composition-based stats. Identities = 116/541 (21%), Positives = 209/541 (38%), Gaps = 45/541 (8%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 ++Q + LRDG QAL + + KL+ L +G +EV FP +S DF V+ Sbjct: 25 LTQPPVWASVDLRDGNQALPEPMGPEHKLEYFNMLVGIGFKEIEVAFPSASADDFNFVRM 84 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + + R+ L + ID ESL+ + H ++ TS +H +E Sbjct: 85 LIERNLIPDDVRISVLTQARRHLIDRTIESLRGVKHAIAHCYVPTSDLHGRFVFNHNREE 144 Query: 118 VIERAIYMVKRARNYTDD--------VEFSCEDAGRTPIADLARVVEAAINAGAT----- 164 V + A+ + + + EFS E+ + + + V A Sbjct: 145 VKQMAVDGTRMVKEAIEREGLWGKVAYEFSPEEFTDSDLDFVVEVCCAVKEVWGPSTPDM 204 Query: 165 -TINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGAR 223 +N+P TV P ++A +I + P +++ +S+H H+D G AV + A+ AGA Sbjct: 205 LILNLPATVERRPPNQYADMIELFCRKFPYLNEVGLSLHAHNDQGCAVAATELALLAGAT 264 Query: 224 QVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 +VEG + G GER GN + + + ++ R V T +N + ++V + + + Sbjct: 265 RVEGTVFGHGERTGNLDVSVLALNMESRG----VRTGLNFSNMPEIVRIVERNSGIEVHP 320 Query: 284 NKAIVGSGAFAHSSGIHQDGVLKNRE---------------NYEIMTPESIGLNQIQ-LN 327 G F SG HQD + K E Y + P +G + + Sbjct: 321 RHPYAGDLVFTAFSGSHQDAIRKGFEHRAEISEFFRQGWKIPYLHLDPADLGRQYEKLIR 380 Query: 328 LTSRSGRAAVKHRMD-EMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQE 386 + S+SG+ V + ++ E G + + K+ D +G + F Sbjct: 381 INSQSGKGGVVYVLEKEFGVYPPKTMHPEIGAVVQKVVDAEGGEINSADLKRIFYDNFVN 440 Query: 387 EPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYN-VE 445 +R++ + S + + E + GNGP+ AV A+ + Sbjct: 441 AEGPYRMENYQRASVGDRSGSNFSWF-INGEKHELSGQGNGPLSAVVHALKSSGLMPFFK 499 Query: 446 LVKYSLTAKGHGKDALGQVDIVANYNGRR-----FHGVGLATDIVESSAKAMVHVLNNIW 500 L +S G DA + +G G ++I ++ A+V +N Sbjct: 500 LEDFSERTLGKDADAKALAFVGLRCGEDSEHTSLVYGAGEHSNIDRAAIAALVSAMNRAV 559 Query: 501 R 501 Sbjct: 560 A 560 >UniRef50_C1ZKW9 Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZKW9_PLALI Length = 418 Score = 361 bits (927), Expect = 3e-98, Method: Composition-based stats. Identities = 149/362 (41%), Positives = 213/362 (58%), Gaps = 2/362 (0%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 S ++++ DTTLRDGEQ A+L +EK +IALALE G+ ++ GFP SS DF++++ + Sbjct: 26 SGRIMLSDTTLRDGEQMPGATLEPEEKREIALALEAAGIHSLDAGFPASSQQDFDAIRLM 85 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVA--EAFRIHTFIATSPMHIATKLRSTLDEVI 119 A+ +K + AL R VE D+D A E+L + FI TSP+H KLR + EV+ Sbjct: 86 AQVIKRPVMTALCRTVEGDVDAADEALAGLAPHKRGVSLFIGTSPLHREYKLRKSRTEVL 145 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE 179 V+ A D V FS EDA RT L E AI AGATTI PDTVG P Sbjct: 146 SIIDRSVRYASKKFDIVAFSPEDASRTEADFLVECYETAIQAGATTIGYPDTVGVLTPER 205 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 I + E VP+I K +++VH H+DLGLAV NSLA + AGA V+ +NGIGERAGN Sbjct: 206 AYVAIRHVMEHVPSIRKVLVAVHMHNDLGLAVANSLAGLTAGAHIVQCTVNGIGERAGNA 265 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 +LEEV MA+ V ++ +N++ ++ QLV++ +P+ NK + G FA +GI Sbjct: 266 ALEEVAMALYVNQEQYGRAVKLNYESLFPLCQLVAKKTGVPMALNKPVAGRTIFATEAGI 325 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 HQDG+LK+ + Y PE +G I+L L SG+ AV H + +GY+ ++ ++ + + Sbjct: 326 HQDGLLKHPDTYLPYRPEVVGGPAIELVLGRHSGKGAVAHHLQNLGYQATDAHVMFILNQ 385 Query: 360 FL 361 Sbjct: 386 IK 387 >UniRef50_A4QAP0 2-isopropylmalate synthase n=225 Tax=cellular organisms RepID=LEU1_CORGB Length = 616 Score = 360 bits (923), Expect = 1e-97, Method: Composition-based stats. Identities = 129/548 (23%), Positives = 223/548 (40%), Gaps = 54/548 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 ++ LRDG QAL +S + K ++ L +MG +EVGFP +S DF+ V+ Sbjct: 63 ITVAPQWCAVDLRDGNQALIDPMSPERKRRMFELLVQMGFKEIEVGFPSASQTDFDFVRE 122 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 I + + + L + E I E+ + A+ +H + +TS + R D+ Sbjct: 123 IIEKDMIPDDVTIQVLVQAREHLIRRTFEACEGAKNVIVHFYNSTSILQRNVVFRMDKDQ 182 Query: 118 VIERAIYMVKRAR-------NYTDDVEFSCEDAGRTPIADLARVVEAAINAGATT----- 165 V + A + + + ++S E T + VV+A + T Sbjct: 183 VKKLATDAAELIKTIAQDYPDTNWRWQYSPESFTGTEVEYAKEVVDAVVEVMDPTPENPM 242 Query: 166 -INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 IN+P TV P +A I ++ V D I+S+H H+D G VG + AGA + Sbjct: 243 IINLPSTVEMITPNVYADSIEWMHRNVNRRDSIILSLHPHNDRGTGVGAAELGYMAGADR 302 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 +EG + G GER GN L + + + + V ++ +I + V + +P Sbjct: 303 IEGCLFGNGERTGNVCLVTLALNMLTQG----VDPQLDFTDIRQIRSTVEYCNQLRVPER 358 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNREN---------------------------YEIMTPE 317 G F SG HQD V K + Y + P+ Sbjct: 359 HPYAGDLVFTAFSGSHQDAVNKGLDAMAAKVKPGANSTDVSWEELRDTEWEVPYLPIDPK 418 Query: 318 SIGLN-QIQLNLTSRSGRAAVKHRMD-EMGYKESEYNLDNLYDAFLKLADKKGQVFDYDL 375 +G + + + + S+SG+ V + M + G + + D +G + Sbjct: 419 DVGRDYEAVIRVNSQSGKGGVAYIMKTDHGLQIPRSMQVEFSAVVQNVTDAEGGEVNSKA 478 Query: 376 EALAF---IGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAV 432 F ++ E L + Q+ + D + A + G++V + GNGP+ A Sbjct: 479 MWDIFATEYLERTAPVEQIALRVENAQTENEDASITAELIHNGKDVTVDGH-GNGPLAAY 537 Query: 433 YQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAM 492 A+ + +VE+ +Y+ A+ G DA ++A NGR+ GVG+A I +S KA+ Sbjct: 538 ANALEK-LGIDVEIQEYNQHARTSGDDAEAAAYVLAEVNGRKVWGVGIAGSITYASLKAV 596 Query: 493 VHVLNNIW 500 +N Sbjct: 597 TSAVNRAL 604 >UniRef50_P58967 2-isopropylmalate synthase 1 n=9 Tax=Euryarchaeota RepID=LEU11_METMA Length = 405 Score = 358 bits (918), Expect = 4e-97, Method: Composition-based stats. Identities = 135/399 (33%), Positives = 214/399 (53%), Gaps = 15/399 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 + I D TLRDGEQ S ++KL +A L+ MG++V+E GFPV S + E V+ I Sbjct: 20 PLDIEICDVTLRDGEQTPGVVFSKEQKLAVASELDSMGIEVIEAGFPVVSADEKEIVKEI 79 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 A Q NSR+C L+R V+ D+D A E + + FIA S MH+ K +L++++ Sbjct: 80 ANQGFNSRICCLSRAVKGDVDAALE----CDVDIVSIFIAMSDMHLKYKYHRSLEDMLGC 135 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAI-NAGATTINIPDTVGYTMPFEF 180 A ++ A ++ V F+ EDA RTP+ L + + +++ DTVG P Sbjct: 136 AKEAIEYATDHGLKVRFAAEDASRTPVERLKQAFKEVENEYKVQYVSLADTVGILNPTTT 195 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 ++S +++ V I +H HDDLG+A N+LAA AGA+Q+ +N IGERAGN S Sbjct: 196 NYLVSEIFKSV----NTAICIHCHDDLGMATANTLAAAEAGAKQLHTTVNAIGERAGNAS 251 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV++A++V+ I + ++ S++VS+ + NKA+VG AF H SGIH Sbjct: 252 LEEVLVALRVQYGIER----YDTTKLNSLSEMVSEYSGITPSVNKAVVGKNAFTHESGIH 307 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 +L+ YE+ PE +G + L + +G+ A+K ++ +G+ L L + Sbjct: 308 VAAILEEPRTYELFLPEMVGGKRN-LVVGKHTGKKALKGIINSIGFCLEREELCALIEKV 366 Query: 361 LKLADKKGQVFDYD-LEALAFIGKQQEEPEHFRLDYFSV 398 ++K + D LE L KQ+++P + FS+ Sbjct: 367 KVCTEEKHKSISRDQLERLITQVKQEQKPSGSEKEKFSI 405 >UniRef50_B0CSN8 Predicted protein (Fragment) n=11 Tax=cellular organisms RepID=B0CSN8_LACBS Length = 603 Score = 357 bits (917), Expect = 5e-97, Method: Composition-based stats. Identities = 122/576 (21%), Positives = 212/576 (36%), Gaps = 84/576 (14%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 ++ I T LRDG QAL ++V++K L + GV +EV +P +S DF+ V+ Sbjct: 23 LTNVPIWLSTDLRDGNQALANPMTVEQKTTFFRQLVKCGVKQIEVAYPAASETDFQFVRG 82 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + + L E I +S+ A+ +H + ATSP RS+ ++ Sbjct: 83 LIENNEVPDDVWIQVLTPAREDLIRRTIDSVAGAKHAILHMYNATSPTFREVVFRSSKEQ 142 Query: 118 VIERAIYMVKRARNYTDDV----------EFSCEDAGRTPIADLARVVEAAINAGAT--- 164 I+ A+ K R T++ E+S E +T V EA A Sbjct: 143 TIKLAVEHTKIVRQLTEECTAKYGTVFKYEYSPETFTQTEPEYALEVCEAVKAAWGKAGT 202 Query: 165 -----TINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVH 219 N+P TV P +A I + +K IIS+H H+D G A+ ++ + Sbjct: 203 GDDRIIFNLPSTVEIAPPNHYADQIENFCRNISEREKIIISLHPHNDRGTAIASAELGML 262 Query: 220 AGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNM 279 AG ++EG G GER GN L + + + ++ ++ +I +V+Q ++ Sbjct: 263 AGGDRIEGCFFGNGERTGNVDLVNLALNFYSQG----INPGLDFSDIQSVIDVVTQCNDL 318 Query: 280 PIPANKAIVGSGAFAHSSGIHQDGVLKNRE--------------------NYEIMTPESI 319 P+ G F SG HQD + K E Y + P + Sbjct: 319 PVHPRHPYAGELVFTAFSGSHQDAIKKGFEVQKIRHAQAAAQGEPQYWNIPYLPIDPADL 378 Query: 320 GLN-QIQLNLTSRSGRAAVKHRMDE-MGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEA 377 G + + + + S+SG+ + + + + Y +ADK+ + D Sbjct: 379 GQDYEAVIRVNSQSGKGGIAFLIKQHLHLDLPRKMQVLFYQVVQAIADKEAREMTVDDIT 438 Query: 378 LAFIGKQQEEPEHF----RLDYFSVQSGSNDIA-------------TAAVKLACGEEVKA 420 AF + + L F + + D L+ + Sbjct: 439 TAFRRTYKFGGSKYAGRLVLRNFRISTERGDDPAEFSGDDAPDERRRFDGTLSVDGVYRV 498 Query: 421 EAANGNGPVDAVYQAINRITEYNVELVKYSLT---------------AKGHGKDALGQVD 465 +GNGP+ A+ A+ + + + Y A G G + + Sbjct: 499 IRGDGNGPLSALLDALRTHLDIDYTIRDYIEHSLSVGFNGQSGQADIAIGEGTEVVAASY 558 Query: 466 IVA-----NYNGRRFHGVGLATDIVESSAKAMVHVL 496 + R GV TDI S KA+++ + Sbjct: 559 VELLYEVEGSKKRSAWGVATDTDITASGIKAVLNAV 594 >UniRef50_A6LPH9 Homocitrate synthase n=10 Tax=Clostridia RepID=A6LPH9_CLOB8 Length = 389 Score = 356 bits (913), Expect = 1e-96, Method: Composition-based stats. Identities = 126/390 (32%), Positives = 199/390 (51%), Gaps = 12/390 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 +++V I DTTLRDGEQ + +EK+ IA L +GVD +EVG P + ++++ I Sbjct: 9 NKKVSIVDTTLRDGEQTAGVVFANEEKIVIAEMLSDLGVDQLEVGIPTMGGDEKKAIKEI 68 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 ++ + A R V DI+ + + + I+ S +HI KL+++ + V+E Sbjct: 69 VKRNLKPSIMAWNRAVVSDIEQSID----CGVDAVAISISVSDIHIQHKLKTSREWVLES 124 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 + V+ A+ V + EDA R L + AA AGA DTVG PF+ Sbjct: 125 MVKSVEFAKKNGLYVSVNGEDASRADKDFLVEYINAAKQAGADRFRYCDTVGIMEPFKIR 184 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 I +Y++ I +HTHDD G+A N++A + GA V +NG+GERAGN +L Sbjct: 185 DDIKYIYDK----TGFDIEMHTHDDFGMATANAVAGIKGGASHVGVTVNGLGERAGNAAL 240 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EEVIMA+ + IN Q SQ VS+ +P KAIVG+ FAH SGIH Sbjct: 241 EEVIMALMLVYGYNG--DGINTQMFREVSQYVSRASGRELPIWKAIVGTNMFAHESGIHA 298 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 DG +K+ +NYE P+ +GL + Q+ + SGRA++ ++ E + +E + + Sbjct: 299 DGAIKDPKNYEAFDPDIVGLER-QIVIGKHSGRASIINKFREYNRELTEDEAKGILELVR 357 Query: 362 KLADKKGQV-FDYDLEALAFIGKQQEEPEH 390 + + + FD ++ L ++ E + Sbjct: 358 ATSVRLKRTLFDKEVVQLYKEYHRRLEERN 387 >UniRef50_Q5KCL7 2-isopropylmalate synthase, putative n=1 Tax=Filobasidiella neoformans RepID=Q5KCL7_CRYNE Length = 639 Score = 355 bits (912), Expect = 2e-96, Method: Composition-based stats. Identities = 119/610 (19%), Positives = 211/610 (34%), Gaps = 108/610 (17%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + I T LRDG Q+L ++ ++KL+ L ++G +EV +P +S D+ V+ + Sbjct: 31 KAPIWLSTDLRDGNQSLANPMTNQQKLRFFRHLVQLGFKEIEVAYPAASETDYNFVRELI 90 Query: 63 RQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + + + L I E++ + +H + ATS + + DE I Sbjct: 91 DRKEVPDDVWIQVLTPARADLIKRTFEAVAGLKHVIVHMYNATSCLFREVVFNNDRDETI 150 Query: 120 ERAIYMV--------KRARNYTDDV--EFSCEDAGRTPIADLARVVEAAINAGA------ 163 + A+ K A ++ E+S E +T V EA A Sbjct: 151 KLAMDHTILIRQLAEKYAESHGTSFRYEYSPETFSQTETPYAVEVCEAVKKAWLGGHGSV 210 Query: 164 ---------TTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNS 214 N+P TV P FA + + +K IIS+HTH+D G AV + Sbjct: 211 WADGRKEERIIFNLPATVEVATPNCFADQVEIFCNSISEREKCIISLHTHNDRGCAVAAA 270 Query: 215 LAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVS 274 V AGA ++EG + G GER GN L + + + + ++ +++ V+ Sbjct: 271 ELGVLAGADRIEGTVLGNGERTGNVDLVTLALNCYSQG----ISPNLDFSDMFSVIDTVT 326 Query: 275 QICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNREN---------------YEIMTPESI 319 + +P+ G F SG HQD + K E Y + P + Sbjct: 327 ECTGLPVHPRHPYAGELVFTAFSGSHQDAIKKGFEAQAKRDHAGDQVWSMPYLPIDPADV 386 Query: 320 GLN-QIQLNLTSRSGRAAVKHRMDE-MGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEA 377 G + + + S+SG+ + + + + Y + ++ G+ Sbjct: 387 GCTYEAVIRVNSQSGKGGIAYIVKSALSLDLPRRMQIAFYKVVQECSEATGREMTSKDIT 446 Query: 378 LAFIGKQQE----------EPEHFRLDYFSVQS----GSNDIA----------------- 406 AF +D FS Q+ G+ D++ Sbjct: 447 TAFRQTYHLGGSIYDGRLVLKSFVTVDLFSSQTPSVAGTPDLSPIRSRSQTRMPPLSLSS 506 Query: 407 --------------------TAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVEL 446 K+ ++ GNGP+ + A+ + + Sbjct: 507 SVAEPSPDRSLDRNLPSMSKRLTAKVLVDGKLHEIVGEGNGPLSSFLNALESDLGIVLSV 566 Query: 447 VKYSLTAKGHGKDALGQVDIV-----ANYNGRR---FHGVGLATDIVESSAKAMVHVLNN 498 +Y+ A G G D + + + F GVG+ DI S KA+V N Sbjct: 567 REYTEHAVGAGSDVKAATYVELIPANVDAKDKTQGGFWGVGVDADITASGLKAVVSAANG 626 Query: 499 IWRAAEVEKE 508 + + Sbjct: 627 FLGQGPIPSQ 636 >UniRef50_Q2JTM1 Homocitrate synthase NifV n=7 Tax=Cyanobacteria RepID=Q2JTM1_SYNJA Length = 395 Score = 355 bits (911), Expect = 3e-96, Method: Composition-based stats. Identities = 117/365 (32%), Positives = 177/365 (48%), Gaps = 15/365 (4%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+ + I DTTLRDGEQA + + EK+ IA L+ +GV +EVG P + E+++ Sbjct: 1 MNSSITINDTTLRDGEQAAGVAFQIPEKISIAALLDAIGVPEIEVGIPAMGAVETEAIRA 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 + + + R V DI + RIH + S IA K + ++ Sbjct: 61 MLSLGLRAHLLGWNRAVPSDILASIR----CGLKRIHISVPVSDRQIAAKFQGDRPRLLR 116 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 + V+ A V EDA RT + + + + A + G DTVG PF Sbjct: 117 QLRQCVEMALEQGLWVSVGAEDASRTSLEQVIELAQMAQSWGCRRFRYCDTVGVLDPFST 176 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 I L + + +HTHDDLG+A N+LA + AGA+ V +NG+GERAGN Sbjct: 177 YKQIRRLVRAI----DIPVEMHTHDDLGMATANALAGIRAGAQSVNTTVNGLGERAGNAP 232 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV+MA++ + ++ + + SQ V++ P+P KAIVG AFAH SGIH Sbjct: 233 LEEVVMALRCTLG---IDVGVDTRRLRELSQQVARASGAPLPPWKAIVGDNAFAHESGIH 289 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGY---KESEYNLDNLY 357 GVL++ + YE PE++G + +L L SGR + + E G + L+ L Sbjct: 290 AAGVLRDPQTYEPFPPEAVGSQR-RLVLGKHSGRHLLLQILKEHGIPVEQIPPGQLEKLL 348 Query: 358 DAFLK 362 + + Sbjct: 349 EQVRQ 353 >UniRef50_B7GT76 2-isopropylmalate synthase n=19 Tax=Bifidobacterium RepID=B7GT76_BIFLI Length = 638 Score = 354 bits (908), Expect = 5e-96, Method: Composition-based stats. Identities = 118/571 (20%), Positives = 207/571 (36%), Gaps = 78/571 (13%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + + LRDG QAL + + KL+ L MG +EVGFP +S DF+ ++ Sbjct: 68 LQRAPRWCSVDLRDGNQALVNPMDSERKLRFWNLLVSMGFKEIEVGFPSASETDFDFIRM 127 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + + + L +C E I E+LK A+ +H + + S + R +E Sbjct: 128 LIERELIPDDVTIVVLTQCREHLIRRTYEALKGAKRAIVHFYNSVSVLQREVVFRKNKEE 187 Query: 118 VIERAIYMVKRARNYTDD-------VEFSCEDAGRTPIADLARVVEAAINA------GAT 164 + + A + ++ ++ E+S E T V A I Sbjct: 188 IKKLATDAAELCKDLENEAKGIDLYYEYSPESFTGTEPEYAVEVCNAVIGVIKPTPEHPM 247 Query: 165 TINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 IN+P TV T P FA + + + + D ++S+H H+D G+ V + AV AGA + Sbjct: 248 IINLPATVEMTTPNVFADEVEYVSTHLDDRDSVVLSLHPHNDEGMGVAATELAVLAGADR 307 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 VEG + G GER GN L V + + + ++ + + V + I Sbjct: 308 VEGCLLGNGERTGNVDL--VTLGLNWLTQG--IDPQLDLSNVPEIRKTVEYCNQIKISER 363 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNREN--------------------YEIMTPESIGLN-Q 323 G+ F SG HQD + K E Y + P+ IG + Sbjct: 364 HPYAGNFVFTAFSGSHQDAIKKGLEARQVAAERAGADLDSFVWLVPYLPIDPKDIGRTYE 423 Query: 324 IQLNLTSRSGRAAVKHRMDE-MGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIG 382 + + S+SG+ + + + + AD + F Sbjct: 424 AIIRVNSQSGKGGMAYLLKTNHNLDLPKRLQIEFDKIVQNYADTTKKEVKDGDIWRLFKD 483 Query: 383 KQQEEPE----------------------HFRLDYFSVQSGSNDIATA------AVKLAC 414 + + +L +V SG + T + Sbjct: 484 EYLPVEQSGMTAAGVVVGDTHDASLEPWGRLKLLKVAVSSGEDGSDTVLKARLLDRGVNV 543 Query: 415 GEE---VKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVAN-- 469 G++ + + GNGP+ A AI+ ++ Y G DA+ + Sbjct: 544 GDDEPVEREASGIGNGPIAAFLNAISNF-GVEASIMDYVEHTMSVGTDAMAASYVECQIG 602 Query: 470 --YNGRRFHGVGLATDIVESSAKAMVHVLNN 498 + + GVG+ + I S+ KA++ +N Sbjct: 603 EADDAQIVWGVGIDSSITTSALKAIISAINR 633 >UniRef50_Q3A2Q7 Homocitrate synthase 1 n=18 Tax=Bacteria RepID=Q3A2Q7_PELCD Length = 400 Score = 353 bits (907), Expect = 8e-96, Method: Composition-based stats. Identities = 127/386 (32%), Positives = 188/386 (48%), Gaps = 13/386 (3%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 +II DTTLRDGEQ S++EK IA L+ +GV +E G P + SV+ + Sbjct: 8 DIIIDDTTLRDGEQTAGVVFSLEEKKTIARMLDDIGVQELECGIPAMGREEQRSVKALVD 67 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 ++R+ R + DI + + + ++ S +HI KLR V E+ Sbjct: 68 LGLHARLITWNRALVDDIRASLQ----CGVNAVDISLSVSDLHIRHKLRKDRHWVREQLK 123 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 + A+ + V EDA R + L ++E A + GA DT+G PF Sbjct: 124 RALGFAKQHDLYVSIGGEDASRADLDFLVELMELARSMGADRFRFCDTLGLLDPFVTFEK 183 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 I L +RV I VHTH+DLG+A N++A V AGAR + +NG+GERAGN +LEE Sbjct: 184 IRYLTQRV----DLDIEVHTHNDLGMATANAIAGVRAGARFINTTVNGLGERAGNAALEE 239 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 V+M +K V I+ S+ V N P+PA K +VG FAH SG+H DG Sbjct: 240 VVMGLK---HACGVKCPIDTSRFVEISRYVGAASNRPVPAWKPVVGERVFAHESGLHVDG 296 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 VLK+ NYE P +G +++ L L +GR + R+ +G + L L + Sbjct: 297 VLKDPRNYEPFEPHEVGSSRL-LVLGKHTGRHGLAARVKGLGLDPGDICLSTLLRRIRAI 355 Query: 364 ADKKGQVF-DYDLEALAFIGKQQEEP 388 + ++ + D +LE L Q +P Sbjct: 356 SQRRKRPVEDAELEGLYRSLAQASQP 381 >UniRef50_C9RKZ6 Pyruvate carboxyltransferase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RKZ6_FIBSS Length = 518 Score = 353 bits (906), Expect = 1e-95, Method: Composition-based stats. Identities = 168/526 (31%), Positives = 265/526 (50%), Gaps = 35/526 (6%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 +++ +D TLRDG QAL + +K + L L ++GV EVGFP SS DFESV + Sbjct: 4 TRKPFFYDVTLRDGNQALPKPWNNAQKKDVYLLLLKLGVQGAEVGFPASSEMDFESVMEL 63 Query: 62 ARQ-----------VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATK 110 A+ KN V LARC+E DI E+++ A RIHTF+ATSP+ + Sbjct: 64 AKLTAQMAEEGDEVAKNVVVSGLARCIESDIQRCWEAVQYAPHPRIHTFLATSPLSMENV 123 Query: 111 LRSTLDEVIERAIYMVKRARNYT---DDVEFSCEDAGRT--PIADLARVVEAAINAGATT 165 L T ++V E+A+ VK A++ DVEFS E G + + V++A + AGATT Sbjct: 124 LHMTPEQVKEKAVKCVKFAKSLVGDRGDVEFSAEHFGDCLENMDFVIDVLKAVVEAGATT 183 Query: 166 INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQV 225 IN+P+TV P + + +YE +P ISVH H+DLG+A ++ + GA Q+ Sbjct: 184 INLPNTVERYRPKLYVDQVKQVYEALPK--NITISVHCHNDLGMATAATVESFFVGATQL 241 Query: 226 EGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANK 285 E A+NG+GER GN + EV + + V T ++ + I+ T+ LVS +PI Sbjct: 242 EVALNGLGERCGNTNFYEVAIGLHNSG----VDTGLHLERIYETAILVSHWSGVPIYIRA 297 Query: 286 AIVGSGAFAHSSGIHQDGVLKNRE----NYEIMTPESIGLNQIQ-LNLTSRSGRAAVKHR 340 ++G+ A H SGIHQDG K ++ Y + IG NQ L+ TS+SGR AV Sbjct: 298 PLIGTEAIVHRSGIHQDGASKTKDMKKGAYRPIDYSIIGRNQNDTLSFTSQSGRTAVYEI 357 Query: 341 MDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQS 400 + + GYK + L +L++ +G++ E + + ++Q + RL + +++ Sbjct: 358 ITKFGYKMTLQEASKLQPVLKRLSEAEGEL---SAERVLDVFREQFVNVNGRLVFNNIEV 414 Query: 401 GSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGK-- 458 ++ E ++ GP++A + I VELVKY Sbjct: 415 IPDENR-FIFHFKKDGEALVKSVTAEGPIEAALMLMREI-GMPVELVKYRQLVVPEKDKL 472 Query: 459 -DALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAA 503 G IV NG G G+++D ++++ +A+ +N I++ A Sbjct: 473 WAGRGLSRIVLKANGEEVEGRGVSSDTLKANMRALFGGVNLIYKKA 518 >UniRef50_A6TTX4 Pyruvate carboxyltransferase n=1 Tax=Alkaliphilus metalliredigens QYMF RepID=A6TTX4_ALKMQ Length = 379 Score = 353 bits (905), Expect = 1e-95, Method: Composition-based stats. Identities = 115/385 (29%), Positives = 178/385 (46%), Gaps = 12/385 (3%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + I DTTLRDGEQ KEK++IA L+ +GVD +E G P+ + + ++ I Sbjct: 2 RDFYIVDTTLRDGEQTPGVVFLKKEKIKIARMLDELGVDYIEAGIPIMGEEEKDVIREII 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 +++ R + D+D + A IH + S +HI KLR VI++ Sbjct: 62 AMNGKAKILTWNRMKKMDVDASL----ACGAKYIHIAVPASDIHIFQKLRKDRKWVIQQV 117 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 +V V EDA R L + +AAI GA + DT+G P Sbjct: 118 QEVVSYGAEKGCIVSVGAEDASRAEEKFLIEIYQAAIKEGAVRLRYADTLGILTPITTYQ 177 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I + + + A + H H+D G+A NSL+A AGA+ ++ ++NG+GERAGN +LE Sbjct: 178 AIKRICDYI----DADLEFHGHNDFGMATANSLSAFQAGAKYIDCSVNGLGERAGNTALE 233 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E++M +K + + I S +V + + +K IVG F+H SGIH D Sbjct: 234 EIVMTLKYLLKSNH---PFEIKRILELSNIVQEASRKIVGESKPIVGKSVFSHESGIHVD 290 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G+LKN YE +P IG + ++ L SGR V +R+ EMG K + + + + K Sbjct: 291 GLLKNPTVYESFSPGEIGRKR-KIVLGKHSGRTTVIYRLQEMGIKVTPKEANEIIEMIHK 349 Query: 363 LADKKGQVFDYDLEALAFIGKQQEE 387 + K+ Sbjct: 350 KYTYDKNPNIDHMLQQWVELKRDTY 374 >UniRef50_B3DXX9 Homocitrate/citramalate synthase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DXX9_METI4 Length = 380 Score = 349 bits (896), Expect = 1e-94, Method: Composition-based stats. Identities = 115/377 (30%), Positives = 175/377 (46%), Gaps = 12/377 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+ ++++ DTTLRDGEQA S ++K+QI L + G+ +E G P S + E+ Sbjct: 1 MNGKILLADTTLRDGEQAPGVFFSPRQKVQIVKLLAQCGIKEIEAGTPSSCKTEMEAFHK 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I R+ A R +D +++K + ++ I S + I+TKLR+ +V+E Sbjct: 61 ILSLGLKVRIVAWGRMTNED----LQAVKSSRVSTVNLSIPLSDIQISTKLRTNRKQVLE 116 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 + V +AR +V ED+ R L +E A GA DTVG P Sbjct: 117 KIKEYVGKAREMGLEVALGGEDSSRAEENFLVEAIEVAKQEGAFRFRYADTVGILDPLCT 176 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 +S L + + H HDD G+A NS+AA AG + + G+GERAGN + Sbjct: 177 YQTLSRLKKW----TSFPLEFHGHDDFGMATANSIAAWRAGVASISATLCGLGERAGNGA 232 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEE+ + +R NV I+ + ++ L S++ IP K+I+G F H SGIH Sbjct: 233 LEEIAFFLALR---ENVDVGIDLKGLFSLCLLTSRLSKRKIPPWKSIIGEEIFLHESGIH 289 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 DG+LKN NYE P IG + L SGR +V +++G SE + Sbjct: 290 VDGILKNPRNYEPFNPSIIGRK-HRFTLGKHSGRKSVLWTYEKLGITLSEQKATEILHKI 348 Query: 361 LKLADKKGQVFDYDLEA 377 K + + Sbjct: 349 KNFTATKKRPPSKEELF 365 >UniRef50_O86511 Uncharacterized AIPM/Hcit synthase family transferase SCO5529 n=62 Tax=Bacteria RepID=LY41_STRCO Length = 534 Score = 348 bits (892), Expect = 4e-94, Method: Composition-based stats. Identities = 140/533 (26%), Positives = 241/533 (45%), Gaps = 33/533 (6%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + +FDTTLRDG Q +L+V +KL IA L+ GV +E G+P ++P D E Sbjct: 7 LDDSFHVFDTTLRDGAQREGINLTVADKLAIARHLDDFGVGFIEGGWPGANPRDTEFFAR 66 Query: 61 IARQV--KNSRVCALARCVEKDIDVA----AESLKVAEAFRIHTFIATSPMHIATKLRST 114 +++ K++++ A + A ++L + A I + H+ LR+T Sbjct: 67 ARQEIDFKHAQLVAFGSTRRAGANAAEDHQVKALLDSGAQVITLVAKSHDRHVELALRTT 126 Query: 115 LDEVIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDT 171 LDE + V + V CE D R VV A AGA + + DT Sbjct: 127 LDENLAMVADTVSHLKAQGRRVFVDCEHFFDGYRANPEYAKSVVRTASEAGADVVVLCDT 186 Query: 172 VGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNG 231 G +P + I + V A + +H DD G AV N+LAAV AGA V+ NG Sbjct: 187 NGGMLPAQ----IQAVVATVLADTGARLGIHAQDDTGCAVANTLAAVDAGATHVQCTANG 242 Query: 232 IGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSG 291 GER GN +L V+ A++++ + +E+ R S ++++ N+ ++ VG Sbjct: 243 YGERVGNANLFPVVAALELKYGKQVLPEG-RLREMTRISHAIAEVVNLTPSTHQPYVGVS 301 Query: 292 AFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEY 351 AFAH +G+H + + + Y+ + PE +G N +++ ++ +GRA+++ + E+G Sbjct: 302 AFAHKAGLHASAIKVDPDLYQHIDPELVG-NTMRMLVSDMAGRASIELKGKELGIDLGGD 360 Query: 352 NLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIA----- 406 + + ++ +++ + Y+ +F + E E L YF V+S Sbjct: 361 R-ELVGRVVERVKERELAGYTYEAADASFELLLRAEAEGRPLKYFEVESWRAITEDRPDG 419 Query: 407 ----TAAVKLACGEEVKAEAANGNGPVDAVYQ----AINRITEY--NVELVKYSLTAKG- 455 A VKL E A GNGPV+A+ + A+ +I ++LV Y + Sbjct: 420 SHANEATVKLWAKGERIVATAEGNGPVNALDRSLRVALEKIYPELAKLDLVDYKVRILEG 479 Query: 456 -HGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEK 507 HG + +V I + + VG+A +++ +S +A+ A V Sbjct: 480 VHGTQSTTRVLISTSDGTGEWATVGVAENVIAASWQALEDAYTYGLLRAGVAP 532 >UniRef50_Q44290 Homocitrate synthase 1 n=45 Tax=Bacteria RepID=NIFV1_ANASP Length = 377 Score = 348 bits (892), Expect = 4e-94, Method: Composition-based stats. Identities = 122/373 (32%), Positives = 179/373 (47%), Gaps = 12/373 (3%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +V+I DTTLRDGEQA +++EK+ IA L+ +GV +EVG P + ++ I+ Sbjct: 2 NKVLINDTTLRDGEQAAGVVFTLEEKVAIAKFLDTIGVPELEVGIPAMGEEEMRAICAIS 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 + + A R V DI + R+H I S + IA K ++R Sbjct: 62 NLGLKANLLAWNRAVISDIKASV----ACGMERVHIAIPVSGIQIAAKFHGQWRVSLQRL 117 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + A + V ED+ R L V A GA+ DTVG PF G Sbjct: 118 KDCISFAVDQGLWVAVGGEDSSRADENFLLDVALYAQEWGASRFRFCDTVGVLDPFTTYG 177 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + L + + VHTH+D G+A N+LA + AGA V + G+GERAGN +LE Sbjct: 178 KVKLLVSALT----IPVEVHTHNDFGMATANALAGIKAGASSVNTTVIGLGERAGNAALE 233 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 EV+MAIK V I+ + SQLV+ +P KAIVG FAH SGIH Sbjct: 234 EVVMAIKRIYG---VDMGIDTPRLLELSQLVAAASGANVPPWKAIVGENTFAHESGIHAH 290 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 GVL+N + YE PE +G + +L + SGR +V + +++ G + ++ DA + Sbjct: 291 GVLQNPDTYEPFAPEEVGWER-RLVVGKHSGRHSVSNLLEQHGIFLNPEETQSVLDAVRQ 349 Query: 363 LADKKGQVFDYDL 375 + KK + + Sbjct: 350 QSIKKKRSLTTEE 362 >UniRef50_D2RXB9 Pyruvate carboxyltransferase n=3 Tax=Halobacteriaceae RepID=D2RXB9_9EURY Length = 438 Score = 348 bits (892), Expect = 4e-94, Method: Composition-based stats. Identities = 150/393 (38%), Positives = 214/393 (54%), Gaps = 18/393 (4%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 +FDTTLRDGEQ+ S S +K QIA L+ MG V+E GFPV+S +FE+V+ IA Sbjct: 59 RVFDTTLRDGEQSPGTSFSYDDKRQIASILDEMGTHVIEAGFPVNSDAEFEAVRDIASST 118 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 + C LAR V+ DI+ A +S +HTF++TS + I + +T DEV+ERA+ Sbjct: 119 STTT-CGLARVVDADIEAALDS----GVEMVHTFVSTSDVQIEDSMHATRDEVVERAVES 173 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 V+R FS DA RT L ++EA AG INIPDT G P F +I Sbjct: 174 VERVTETGTTCMFSPMDATRTDEQFLLEIIEAVSEAGVDWINIPDTCGVATPTRFRAMIE 233 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245 + A I VHTHDD GLA N+LA + AGA Q + ++N IGERAGN + EE + Sbjct: 234 KVCAH----TDARIDVHTHDDFGLATANALAGIEAGADQAQVSVNSIGERAGNAAYEEFV 289 Query: 246 MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVL 305 MA++ + T I+ I S +V + M P NK +VG AF+H SGIH GV+ Sbjct: 290 MAVES---LYQTDTGIDTTRITELSNVVEEKSGMATPGNKPVVGDNAFSHESGIHAAGVI 346 Query: 306 KNRENYEI--MTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 +N + +E MTPE +G + +L L +G +V+ R+ E+G++ ++ + + Sbjct: 347 ENSDTFEPGVMTPEMVGAER-RLILGKHTGTHSVRERLAELGFEPTDDQVRAVTRRVKDF 405 Query: 364 ADKKGQVFDYDLEALAFI---GKQQEEPEHFRL 393 +K +V DLE A +Q +E E R+ Sbjct: 406 GAEKRRVTVDDLERFAEEAGIERQSKEEEEVRV 438 >UniRef50_A0LSS5 2-isopropylmalate synthase n=12 Tax=Bacteria RepID=A0LSS5_ACIC1 Length = 554 Score = 346 bits (889), Expect = 8e-94, Method: Composition-based stats. Identities = 133/520 (25%), Positives = 243/520 (46%), Gaps = 33/520 (6%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 ++DTTLRDG Q +L+V +KL IA L+ +GV +E G+P + P D E + Sbjct: 14 PAGFQVYDTTLRDGAQGEGMALTVADKLAIARHLDDLGVGFIEGGWPGALPKDTEFFRRA 73 Query: 62 ARQV--KNSRVCALARCVEKDIDVAAE----SLKVAEAFRIHTFIATSPMHIATKLRSTL 115 ++ +N+ + A + + V A+ +L AE + + H++ LR++L Sbjct: 74 RTELTLRNAVLVAFGATRKPESRVEADPQVLALLEAETPAVCLVAKSHVRHVSEALRTSL 133 Query: 116 DEVIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTV 172 DE + V R V E D V A +GA + + DT Sbjct: 134 DENLAMIRDTVAFFRREGRRVFLDAEHFFDGYAADPQYAVECVRVAAESGAEVVVLCDTN 193 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G +P A ++ V + +H HDD G AV N+LAAV AG QV+G +NG Sbjct: 194 GGMLPPRIADVV----HEVAERTGVPLGIHCHDDTGCAVANTLAAVDAGVVQVQGVVNGY 249 Query: 233 GERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 GER GN +L V+ ++++ + E+ R S ++++ N P AN+ VG A Sbjct: 250 GERCGNANLITVVANLELKMGRRVLPPG-RLAELGRVSHAIAEVANQPPRANQPYVGLSA 308 Query: 293 FAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKES--E 350 FAH +G+H + + + Y+ + P +G N +++ ++ +GRA+V+ + ++G+ S Sbjct: 309 FAHKAGLHASAIKVSPDLYQHIDPALVG-NDMRMLVSEMAGRASVELKSRQLGFDLSGQR 367 Query: 351 YNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEP---EHFRLDYFSV----QSGSN 403 + + + L + +G +F+ + + +++ + F L+ + V ++ Sbjct: 368 DAVSRIVERVKNL-EARGFMFEAADASFELLLREELDGVPTRFFDLESWRVIVERRADGE 426 Query: 404 DIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEY------NVELVKYSLTAK--G 455 ++ A VK+ E A GNGPV+A+ +A+ + E +ELV Y + Sbjct: 427 VVSEATVKVVVKGERIVATAEGNGPVNALDRALRQALERLYPQLAELELVDYKVRILDGS 486 Query: 456 HGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHV 495 HG A+ +V I + + +G+ +++ +S +A+ Sbjct: 487 HGTGAVTRVLIETSDGETEWTTIGVDGNVISASWQALDDA 526 >UniRef50_B0TAQ1 Homocitrate synthase, nifv n=4 Tax=Clostridiales RepID=B0TAQ1_HELMI Length = 380 Score = 346 bits (889), Expect = 1e-93, Method: Composition-based stats. Identities = 109/389 (28%), Positives = 172/389 (44%), Gaps = 12/389 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M Q+V + DTTLRDGEQ + +EK +A L GV +E G P + E++ Sbjct: 1 MRQRVWLMDTTLRDGEQTPGVAFCPQEKALLARRLAEAGVHEIETGVPAMGEDEQETIAR 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I + +RV R V D E+ + + +S I KLR + V++ Sbjct: 61 IVKLNLPTRVTTWNRAVISD----LEASLNCGVRSVAICLPSSDQQITQKLRQSRQWVLD 116 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 + V+RA+ V EDA R L ++ A + I DT+G P Sbjct: 117 QMGACVRRAKAEGLYVVIGLEDASRADPQFLIQLGLEAERLKVNRLRISDTLGILDPIRT 176 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 + L + + +H H+DLG+A N+++A+ AGA+ + G+GERAGN Sbjct: 177 FNLFDRLTSSL----SIPLEIHAHNDLGMATANTVSAIQAGAKAASVTVCGLGERAGNAP 232 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV +A++ T IN + +LVS PIP +K +VG AF H+S IH Sbjct: 233 LEEVALALR---QCCAADTRINLALLPALCRLVSWSTRRPIPFSKPVVGRDAFTHASSIH 289 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 DG+ K+R NYE PE +G + ++ SGR + + G+ + + L Sbjct: 290 VDGLNKDRSNYEAYPPEYVGR-RHRIAFGKYSGRKLLAELLKAQGHDLDQEEMTQLLLNV 348 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEPE 389 +L+ + G+ + + Sbjct: 349 RQLSQVLKRPLRQHDIVDLIFGETSAQRD 377 >UniRef50_D1XS06 2-isopropylmalate synthase n=1 Tax=Streptomyces sp. ACTE RepID=D1XS06_9ACTO Length = 612 Score = 346 bits (889), Expect = 1e-93, Method: Composition-based stats. Identities = 111/539 (20%), Positives = 188/539 (34%), Gaps = 45/539 (8%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +++ + LRDG QAL + K ++ L MG +EVG+P +S DF V+ Sbjct: 74 LTRAPLWVPVDLRDGNQALAEPMDAARKRRMFDLLVAMGFKEIEVGYPSASETDFGFVRH 133 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 +A + V ID S++ +H + AT+P+ L + E Sbjct: 134 LAESGAVPDDVTVSVFTAARSDLIDRTIASVEGLPRTLVHLYTATAPVWRDVVLGRSRAE 193 Query: 118 VIERAIYMVKRAR-------NYTDDVEFSCEDAGRTPIADLARVVEAAINAG------AT 164 + EFS E T + V ++ Sbjct: 194 LHAMITDAATHLLRRAGERPGADIRFEFSPEVFNLTEPDFVLEVCDSLTELWEASPDRPV 253 Query: 165 TINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 N+P TV P +A I ++ + D I+SVH H+D G V + AV AGA++ Sbjct: 254 VHNLPATVEIATPNVYADQIEYMHRHLARRDSVILSVHPHNDRGTGVACAELAVLAGAQR 313 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 VEG + G GER GN L + + + + V ++ +I ++V +P+ Sbjct: 314 VEGCLFGNGERTGNVDLVTLALNLFAQG----VDPMVDFSDIDAVREVVEHCNRLPVHPR 369 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNRE--------------------NYEIMTPESIGLN-Q 323 G SG HQD + K Y + P IG + Sbjct: 370 HPYGGELVHTAFSGTHQDAIAKGMARHAKRAAEQGVPAAEAPWEVPYLPVDPGDIGRTYE 429 Query: 324 IQLNLTSRSGRAAVKHRMD-EMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIG 382 + + S+SG+ V H + G + + ++ D G+ F Sbjct: 430 EVIRINSQSGKGGVAHLLRAHHGLDLPQAMRPDFSRTVQRVTDGTGRELTAGELGELFRT 489 Query: 383 KQ--QEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRIT 440 +S + + T L + GNGP+ A+ A+ Sbjct: 490 TYLAAAGQGSVEAVSWSTAETAPGVHTFTCVLRVDGREHSCRGTGNGPLAALTDALRTA- 548 Query: 441 EYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNI 499 V ++ Y A G D+ +G G G T ++ +S +++ +N Sbjct: 549 GVTVGVLGYWEHATTAGPDSPAAAYAECRVDGVTAWGAGWDTSVLTASVHSVLSAVNRA 607 >UniRef50_C4XS62 Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio magneticus RS-1 RepID=C4XS62_DESMR Length = 394 Score = 346 bits (887), Expect = 2e-93, Method: Composition-based stats. Identities = 137/360 (38%), Positives = 189/360 (52%), Gaps = 3/360 (0%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 +II DTTLRDG Q S+ +K+ IA ALE GVDV+E GFP G+ E+V+ +A Sbjct: 10 LIISDTTLRDGAQMPGVHFSINDKVAIAQALEAAGVDVIEAGFPAGGAGEIEAVRQVAAA 69 Query: 65 VKNSRVCALARCVEKDIDVAAESL--KVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 + AL R V+ D+D A ++L AE + F+ATSP+H KL T + + Sbjct: 70 TARPLIMALCRAVDADVDAAWQALGDAPAERRGVGVFLATSPLHRRHKLGKTKAQCLAMI 129 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 V AR V F CED RT A L AA++AGAT I PDTVG P Sbjct: 130 ASSVAYARQRFARVTFGCEDGSRTEPAFLREAYTAAMDAGATAIGFPDTVGVLTPETARR 189 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I+ L R+ + H H+DLGLA N+LAA+ AGA V + GIGERAGN +LE Sbjct: 190 RIAMLV-RLAQPRGVKVRAHFHNDLGLATANTLAAIAAGADIVHLTVGGIGERAGNAALE 248 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E +MA+ + ++ + +LV+Q +P NKA+ G+ FA ++G+HQD Sbjct: 249 ETVMALTLHPGQYRRAINVDTTRLTALCRLVAQRAGFTLPPNKAVTGANVFATAAGVHQD 308 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G+LK+ + Y PE +G I+L L+ SG+AA+ R E+G S L Sbjct: 309 GLLKHPDTYLPFRPELVGAEGIRLPLSPLSGKAALALRYTELGIALSADELSRASRLVKD 368 >UniRef50_D2L197 Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio sp. FW1012B RepID=D2L197_9DELT Length = 400 Score = 345 bits (884), Expect = 4e-93, Method: Composition-based stats. Identities = 139/364 (38%), Positives = 200/364 (54%), Gaps = 3/364 (0%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 +I+ DTTLRDG Q SV +K+ IA AL GV V+E GFP S + E+V+ I + Sbjct: 17 LILSDTTLRDGAQMPGVRFSVDDKVAIAKALADAGVGVIEAGFPAGSEREIEAVRRICAE 76 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVA--EAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 V R+ L R V DID A E+L A E + F+ATSP+H KL + + ++ Sbjct: 77 VPGPRIMVLCRAVAGDIDAAWEALADAAPEGRGVGIFLATSPLHRRHKLGKSKAQCLDMI 136 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 V AR V FSCED RT A L + A++AGAT I PDT+G P Sbjct: 137 GRAVAYARKRFLKVTFSCEDGSRTEPAFLRQAYGVAMDAGATGIGFPDTLGVLTPEAVRR 196 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + L + + + VH H+DLGLA N+LAAV AGA V + GIGERAGN +LE Sbjct: 197 RVRML-AALAHPRGVRLRVHFHNDLGLATANTLAAVAAGADIVHLTVGGIGERAGNAALE 255 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E +MA+ + + ++ ++ +LVS++ +P+ ANKA+VG+ FA S+G+HQD Sbjct: 256 ETVMALILNQKQYRRSIGVDPAKLTGLCRLVSRLSGVPLAANKAVVGANIFATSAGVHQD 315 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 G+LK+ + Y PE++G + I+L L+ SG+AA+ R+ E+G + S L Sbjct: 316 GLLKHPDTYLPFRPEAVGADGIRLPLSPLSGKAALALRLAELGIELSPDELGRTSRIMKN 375 Query: 363 LADK 366 + Sbjct: 376 AGKE 379 >UniRef50_A6DIP7 2-isopropylmalate synthase n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DIP7_9BACT Length = 554 Score = 343 bits (881), Expect = 7e-93, Method: Composition-based stats. Identities = 115/522 (22%), Positives = 217/522 (41%), Gaps = 44/522 (8%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 ++Q LRDG QAL L++++K L ++G +E+GFP +S D++ + Sbjct: 22 ITQSPTWCAVDLRDGNQALPDPLTLEQKKIYFDILVKIGFKEIEIGFPSASKDDYDFCRH 81 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + + L + ++L+ +H ++ATS +H L + E Sbjct: 82 LIDNKVIPDDVMISVLVPARPDLVVKTMDALRDVPKATVHFYVATSDLHREHVLGKSHQE 141 Query: 118 VIERAIYMVK-------RARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGAT------ 164 V E V+ + + T +EFS E+ T + V + I Sbjct: 142 VFEMCTATVQSIKEEASKLKESTFYLEFSPEEFTDTDLDFAVEVCDHVIEQWQPAADEKV 201 Query: 165 TINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 +N+P TV P +A +I ++ + ++AIIS+H H+D+G AV ++ A+ AGA + Sbjct: 202 ILNLPATVERRPPTHYADMIELFQRKLKS-EQAIISLHAHNDMGCAVASTQLAIQAGAHR 260 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 VEG + G GER+GN L +++ ++ + T ++ ++ ++ +S++ NMP Sbjct: 261 VEGTLFGQGERSGNVDLITLVLNLQYLG----IDTGLDFSDLMNITEQISELTNMPPHER 316 Query: 285 KAIVGSGAFAHSSGIHQDGVLKN--------------RENYEIMTPESIGLN-QIQLNLT 329 VGS F+ SG HQD + K+ + Y + P +G + + + Sbjct: 317 HPYVGSLVFSAFSGSHQDAIHKSTLRKDELMETFGRWKIPYLHIDPADVGREFENLIRIN 376 Query: 330 SRSGRAAVKHRMD-EMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEP 388 S+SG+ + H ++ E K + + A++ + F Sbjct: 377 SQSGKGGIAHIIEKEHNIKLPRFVQVDFAKRVQAYAEEVSREVSTQEVWKVFEEAYIAPK 436 Query: 389 EHFRLDYFSV----QSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNV 444 +L + ++I A +++ E A GNGP+ A A+ ++ + Sbjct: 437 NP-KLVLNNYWPYPDEDQSEIVNAKIEVEFKGETFTHEATGNGPISAFVAALKKLDIPDF 495 Query: 445 ELVKYSLTAKGHGKDALGQVDIVA--NYNGRRFHGVGLATDI 484 L + + G A I + NG G G ++I Sbjct: 496 VLEHFGEDSIGDSAQAEAVSSISVKNSDNGSVHIGFGYHSNI 537 >UniRef50_Q2FKU8 2-isopropylmalate synthase n=3 Tax=Methanomicrobiales RepID=Q2FKU8_METHJ Length = 393 Score = 343 bits (880), Expect = 1e-92, Method: Composition-based stats. Identities = 126/378 (33%), Positives = 197/378 (52%), Gaps = 13/378 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 + I D TLRDGEQ S + EK IA L+ +G++V+E GFP+ S + E V+ I Sbjct: 3 PWHIEICDVTLRDGEQTPGVSFTADEKKDIASRLDAIGIEVIEAGFPIVSAHEKEMVRNI 62 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 +R ++++C L+R +D+D A + AE I FIA S +H+ K + D V+ Sbjct: 63 SRLGLSAKICGLSRACREDVDAALD----AEVDMIGLFIAPSDLHLKYKHKKPRDVVVAN 118 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 A+ + A ++ V F EDA RT L + A + AT + DT G P E A Sbjct: 119 ALEQLDYAVDHGLIVRFGAEDASRTDPDILVDIYRQAADHKATYVTYADTTGCLTPLEVA 178 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 ++ L + P I++H H+DLG A N+L A GA Q+ +NG+GERAGN L Sbjct: 179 TVMKDLVPKTP----IPIAMHAHNDLGCATANTLIAAELGAYQLHTTVNGLGERAGNARL 234 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EEV++++ ++ I T + EI S+ V Q + +PA K +VG+ AFAH SGIH Sbjct: 235 EEVLVSLVLKGGI----TRYDLTEIPALSERVQQYTGIFMPATKPVVGANAFAHESGIHI 290 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 +L+N E YE + PE +GL + + L +G+ A+ H + GY ++ + + + Sbjct: 291 AAILENPETYEFIPPELLGLER-RFILGKHTGKRALVHILTSFGYHITDEQVMQVLELIK 349 Query: 362 KLADKKGQVFDYDLEALA 379 ++ K + L + Sbjct: 350 DKSEDKCSINQRVLAEII 367 >UniRef50_Q1QBL0 2-isopropylmalate synthase n=5 Tax=Bacteria RepID=Q1QBL0_PSYCK Length = 594 Score = 342 bits (877), Expect = 2e-92, Method: Composition-based stats. Identities = 114/544 (20%), Positives = 214/544 (39%), Gaps = 55/544 (10%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + + I LRDG QAL +++++K++ L +G +E+GFP ++ +F+ + Sbjct: 47 LEKSPIWASVDLRDGNQALIDPMTIEQKMRFFETLIDVGFKEIEIGFPSAAQVEFDFARK 106 Query: 61 IARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + + + L + E I ESLK A+ +H + +T + E Sbjct: 107 LIEENHVPDDVTLQVLVQAREHLIARTFESLKGAKRAIVHVYNSTCRIQREKVYAKDKAE 166 Query: 118 VIERAIY----MVKRARNY---TDDVEFSCEDAGRTPIADLARVVEAAINAGAT------ 164 + E A+ +V+ A Y ++S E +T V +A + Sbjct: 167 IKEIAVTGAKLLVEYAAKYPETEWVFQYSPESFSQTETEYAVEVCDAVCDVWRPENGQEV 226 Query: 165 TINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 +N+P TV +MP FA + + + IS+HTH+D G AV + V AGA + Sbjct: 227 ILNLPATVEASMPNVFADQVEYFCRNLAKREHVTISLHTHNDRGCAVAAAELGVLAGADR 286 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 +EG + G GER GN + + M + + + ++ + Q+VS+ N+P+ Sbjct: 287 IEGTLLGNGERTGNMDIMVMAMNLFSQG----IDPELDFSNMSEIVQVVSECNNLPLHPR 342 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNRE---------------NYEIMTPESIGLNQIQLN-L 328 VG F SG HQD + K + Y + P IG + + + Sbjct: 343 HPYVGELVFTAFSGSHQDAIKKCLDYNEKHVEKTENVWDVAYLPIDPAHIGRSYQDVVRI 402 Query: 329 TSRSGRAAVKHRMDE-MGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEE 387 S+SG+ V + + G+ + + K A+ + D F ++ Sbjct: 403 NSQSGKGGVAYILQRNYGFNLPRWMQIDFSGVVQKQAETTARELQNDEILQTFEDTYLQQ 462 Query: 388 PEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELV 447 F L ++V + ++ + +GNGP+ + + + T ++ ++ Sbjct: 463 GS-FELLDYTVNN-KGGEVYFNGQVQMNGDTITIDGDGNGPLSSFIDGLAQHTGKSIHVI 520 Query: 448 KYSLTAK------GHG----------KDALGQVDIVANYNGRRFHGVGLATDIVESSAKA 491 Y+ A G G +A I N +G + G+G + V + K Sbjct: 521 NYAEHAINPQHNSGDGINDDNNRDNKTNANAAAYIQLNVDGEVYSGIGTCSSTVSAMLKG 580 Query: 492 MVHV 495 + Sbjct: 581 ALSA 584 >UniRef50_C5S831 2-isopropylmalate synthase n=20 Tax=Bacteria RepID=C5S831_CHRVI Length = 534 Score = 342 bits (877), Expect = 2e-92, Method: Composition-based stats. Identities = 142/526 (26%), Positives = 225/526 (42%), Gaps = 27/526 (5%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIAL-ALERMGVDVMEVGFPVSSPGDFESVQTI 61 ++V+I DTTLRDGEQ S + EKL +A LE++ VD +EV S G+ +V I Sbjct: 21 RRVLIMDTTLRDGEQTQGVSFAPAEKLNLAKVLLEQVRVDRIEVASARVSSGEASAVAQI 80 Query: 62 AR------QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 V+ V D + + + A ++ S H +L TL Sbjct: 81 IDWARERGLVERVEVLGFV-----DGGASVDWICGAGGQVLNLLAKGSEKHCRGQLGKTL 135 Query: 116 DEVIERAIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTV 172 DE + A++ V ED R + +VE + G +PDT+ Sbjct: 136 DEHAADVRATIAAAQSRGLRVNLYLEDWSNGYRDNPDYVYGLVERLADVGIGHFMLPDTL 195 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G P + IS + R P++ H H+D GLA N LAAV AGA V +N + Sbjct: 196 GVMTPDQVFTAISDMVGRFPSL---QFDFHPHNDYGLATANVLAAVQAGAAAVHCTVNCL 252 Query: 233 GERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 GERAGN SL EV + ++ + D I+ + R S+LV I N IVG+ Sbjct: 253 GERAGNASLAEVAVNLRDQLD---CALGIDETHLARVSELVESFSGKRISDNAPIVGADV 309 Query: 293 FAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYN 352 F ++GIH DG K + ++PE + + L +G+A++ ++ + + SE N Sbjct: 310 FTQTAGIHADGDKKGSLYHSRLSPERFARRR-KYALGKLAGKASLAKNLERLDIELSEEN 368 Query: 353 LDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKL 412 + ++L D K + DL + + ++ +H L +V S + + A +++ Sbjct: 369 QRKVLQRIVELGDSKKTITTEDLPFIIAEVLESKDYDHAELLSCTVSSSLDLESMAGIRI 428 Query: 413 ACGEEVKAEAANGNGPVDAVYQAINRITEYN----VELVKYSLTAKGHG-KDALGQVDIV 467 GE+V GNG DA A+ RI + L+ Y + G DAL + I Sbjct: 429 RLGEQVFTGTGTGNGGFDAFTNALGRILKRQGLTLPPLIDYEVRIPKGGRTDALTECSIT 488 Query: 468 ANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKA 513 G+ + V ++ A + +LN A E + A Sbjct: 489 WQTERGELRTRGVHANQVFAAIGATMRMLNIRMHRALAESRREGGA 534 >UniRef50_C3MPM7 2-isopropylmalate synthase n=19 Tax=Thermoprotei RepID=LEU1_SULIL Length = 461 Score = 341 bits (874), Expect = 5e-92, Method: Composition-based stats. Identities = 124/391 (31%), Positives = 197/391 (50%), Gaps = 17/391 (4%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 +V I D+TLR+GEQ +V ++++IA AL +GV ++E G P SP +E ++ I + Sbjct: 3 KVGILDSTLREGEQTPGVIFTVDQRVEIAKALSDLGVSMIEAGHPAVSPDIYEGIKRIVK 62 Query: 64 QVK----NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 K S + +R V++DI++AAE E RI F S +H+ K ++T +E + Sbjct: 63 LKKEGIITSEIVGHSRAVKRDIEIAAE----LEVNRIAIFYGVSDLHLKAKHKATREEAL 118 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE 179 + A+N+ V F+ ED RT L V + A +AGA ++I DTVG P + Sbjct: 119 RTIAETISYAKNHGVKVRFTAEDGSRTDFDFLVTVSKTARDAGADRVSIADTVGILYPSK 178 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 + S L VPN++ +H H+DLGLAV N+LAA+ GA + +NG+GER G Sbjct: 179 TKELFSALTREVPNLE---FDIHAHNDLGLAVANALAAIEGGATIIHATVNGLGERVGIV 235 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 L+++ AIK I + ++ S LV + +P+P N I G AF H +G+ Sbjct: 236 PLQQIAAAIKYHFGIEV----VKLDKLQYVSSLVEKYSGIPMPPNYPITGDYAFLHKAGV 291 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 H GVL + YE M PE+ G + + +G+ A++ + +++G K S+ +D + Sbjct: 292 HVAGVLNDPRTYEFMPPETFGRTR-DYTIDKYTGKHALRDKYEKLGVKISDAEMDQILAK 350 Query: 360 FLKLADKKGQVFDYDLEALAFIGKQQEEPEH 390 D DL LA + Sbjct: 351 IKS-NTTIRFYRDVDLLELAEEVTGRVLKPR 380 >UniRef50_B8I2I3 Pyruvate carboxyltransferase n=1 Tax=Clostridium cellulolyticum H10 RepID=B8I2I3_CLOCE Length = 388 Score = 340 bits (872), Expect = 8e-92, Method: Composition-based stats. Identities = 107/386 (27%), Positives = 190/386 (49%), Gaps = 17/386 (4%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 + DTTLRDGEQ + ++K++IA L++ G++ ++ GF +S + S++ I Sbjct: 16 KFFFCDTTLRDGEQVSGIRYTPEQKVEIAQMLDKAGIESIDAGFAATSEEERLSIRKICD 75 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRST----LDEVI 119 R+ ++ R + +DID + FI S +H+ K ++ Sbjct: 76 LGLKMRIMSMCRVIREDID----FASSCGVEGVILFIPGSDIHLKAKFGEDIPAVRKNIV 131 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE 179 ++A+ +K A++ VEF ED+ RT L ++ A GA + DT+GY P Sbjct: 132 QKAMDAIKYAKDKGLFVEFGVEDSTRTDFNVLLEILSQAEQEGADILGTTDTIGYLTPER 191 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 I L + K I VH H+D+GLA N++A + AG +NG+GERAGN Sbjct: 192 TYNFIKKLVRNL----KLPIGVHCHNDMGLATANTIAGLLAGGGYCSPTVNGMGERAGNA 247 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 SLEEVIM +KV + + + + S+ V + + + K IVG A++H SGI Sbjct: 248 SLEEVIMILKVLYNQ---DLKYDTKILGELSKTVEKYSGISMDIFKPIVGQNAYSHESGI 304 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 H G+LK+ YE+ P+ +G ++ + + +G+ ++H + G++ SE +++ + Sbjct: 305 HVHGMLKDINTYELFDPQLVGHSR-KYEMGKHAGKHTIQHILKTNGFELSEEEVED-FWR 362 Query: 360 FLKLADKKGQVFDYDLEALAFIGKQQ 385 +K +K G + + + ++ Sbjct: 363 HMKSNEKAGVYYSVEDVITEYKKLRR 388 >UniRef50_Q8KTR5 Alpha-isopropylmalate synthase n=14 Tax=Candidatus Tremblaya princeps RepID=Q8KTR5_TREPR Length = 390 Score = 334 bits (857), Expect = 5e-90, Method: Composition-based stats. Identities = 154/374 (41%), Positives = 220/374 (58%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + I DTTLRDGEQA + K ++A LE GVDV+E GF SS DFE+++ I+ Sbjct: 9 IAILDTTLRDGEQAPCIVMGPDAKAEMARRLEIAGVDVVEAGFAASSSSDFEAIRRISCC 68 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 V+ VC+LAR V D+ AA++L+ A RIH FI +S +HI KLR +V++RA Sbjct: 69 VRGCVVCSLARAVGHDVRKAAKALEFARHPRIHVFIGSSSLHIEEKLRMHPLDVVDRAAA 128 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 MV+ AR Y DDVEFS ED+ R + L + +AA+ AGAT +N+ DTVG+ +P + + + Sbjct: 129 MVRLARAYCDDVEFSPEDSSRADPSFLCSLAKAAVEAGATIVNVTDTVGHGIPEQLSDVA 188 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 L VP D+ +SVH H+D+GLA+ N++AA+ A Q E + GIGERAGN +LEEV Sbjct: 189 GMLCRSVPISDRVTLSVHCHNDVGLALANTMAAIACCAGQAECTVTGIGERAGNAALEEV 248 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 ++A + + ++ + + +QL S I +PA K +VG AFAH+SGIHQDGV Sbjct: 249 VVAAGLEYSGAGMDVRVDARHMRSIAQLASAIARRRLPATKPVVGCHAFAHASGIHQDGV 308 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 +KNR YE + E +G + L SG A+++R++ G + L LA Sbjct: 309 IKNRRTYEALRAEDVGGRGGSIVLGKLSGTHALRNRLEGGGVTIGAMGVPRLATMMKGLA 368 Query: 365 DKKGQVFDYDLEAL 378 V+D L AL Sbjct: 369 SHLPVVYDSALAAL 382 >UniRef50_B4S9H2 Pyruvate carboxyltransferase n=13 Tax=Bacteria RepID=B4S9H2_PROA2 Length = 390 Score = 332 bits (851), Expect = 2e-89, Method: Composition-based stats. Identities = 117/387 (30%), Positives = 185/387 (47%), Gaps = 12/387 (3%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + V I DTTLRDGEQA + + +EK IA L GV+ +E+G+P S + + IA Sbjct: 13 RPVWIIDTTLRDGEQAPGVAFTPEEKKTIAGKLAECGVNELEIGYPAISSEEQAVITEIA 72 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 R R+ + AR +DID A + +H S +++ + + V E+ Sbjct: 73 RMQLPLRLTSWARAKWEDIDAAIR----CKTQGVHISFPLSELYLQL-MDKPYEWVEEQL 127 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 +V +A+ Y D V +DA RT L R + A+ GA I I DTVG P Sbjct: 128 HLLVPKAKKYFDFVSVGGQDATRTGPDILERFIREAVECGADRIRIADTVGIATPLHLMQ 187 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 +IS + + VP A + H H+DLG+A N+ +A+ AG V ++ G+GERAGN +LE Sbjct: 188 LISRIKKAVP----ATLEFHAHNDLGMATANAFSAMEAGCDAVSVSVTGLGERAGNAALE 243 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 E+ +A+K+ H++I + + +V++ N I K ++G+ F H SGIH + Sbjct: 244 ELAIALKLSG---RYHSSIKTERLQELCGIVAKASNRNIEDQKPVIGASVFRHESGIHCN 300 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 +LKN +Y+ P IG + +L + SG AA++H + G L Sbjct: 301 ALLKNPLSYQPFLPGEIGRDNYELVIGKHSGSAAIQHVLAGNGIAIDRKEASRLLAPVRM 360 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPE 389 AD+ + D + + Sbjct: 361 TADRNKRGISADELTRIYQQYIVNPQD 387 >UniRef50_A2QSZ0 Contig An09c0020, complete genome n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2QSZ0_ASPNC Length = 566 Score = 331 bits (850), Expect = 3e-89, Method: Composition-based stats. Identities = 113/537 (21%), Positives = 196/537 (36%), Gaps = 51/537 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 ++Q T LRDG QAL ++ KL+ L ++G +EV +P +S +F+ + Sbjct: 29 LTQAPRWLSTDLRDGNQALVQPMNGDLKLRYFQTLIKLGYKEIEVSYPSASQTEFDFTRY 88 Query: 61 IARQV----KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 + ++ + +A C ++ I E+++ A +H ++TS + T Sbjct: 89 LISTPGIVPDDTWIQVMAPCRDELIQRTIEAVRGARKVVLHIHLSTSDLFREIVYLMTKK 148 Query: 117 EVIERAIYMVKRARNYT------------DDVEFSCEDAGRTPIADLARVVEAAINAGAT 164 E+I+ A+ ++ R T +EF+ E+ T + + EA A Sbjct: 149 EMIDLAVRCMRMIRELTKDSLDAEMRKTEWTMEFTLENFQDTSVEFALEICEAVKAAWEP 208 Query: 165 T------INIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAV 218 T N+P TV +MP FA I + +K +SVH H+D G V + A Sbjct: 209 TTENKIIFNLPSTVEISMPNVFADQIELFCRGISEREKVCVSVHPHNDRGCGVAAAEMAQ 268 Query: 219 HAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICN 278 AGA +VEG + G GER GN L + + + + + +N + +V Sbjct: 269 LAGADRVEGCLFGNGERTGNVDLVTLALNLYTQG----ISPRVNLGNLNEVVAMVEDCTK 324 Query: 279 MPIPANKAIVGSGAFAHSSGIHQDGVLKN------------------RENYEIMTPESIG 320 +PI G F +G HQD + K R Y M P +G Sbjct: 325 IPIHPRAPYAGKYVFCTFTGTHQDAIRKGYNQLQESEKHDATQTPKWRMPYLPMDPADLG 384 Query: 321 LNQIQLN-LTSRSGRAAVKHRMDE-MGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEAL 378 + + S+SG++ V ++E A+ G + Sbjct: 385 RQHEAIVRVNSQSGKSGVAWLLEESFHIHMPRELEIEFTKIVKTYANMSGFEITQETIRR 444 Query: 379 AFIGKQ-QEEPEHFRLDYFSVQSGSNDIATAAVKLA--CGEEVKAEAANGNGPVDAVYQA 435 F + E RL D V+L A G+ + + A Sbjct: 445 LFREHYMHADSEKARLLDCRADETKGDRVVTQVQLKVAVEGSEHDLEATGSELLPTILDA 504 Query: 436 INRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAM 492 + + Y E + + + V + + N GVG+ D + + A+ Sbjct: 505 L-KPLGYGFEALDSQMQYTTNRDTITSFVRLGTSEN-FAAWGVGMHKDTAWAVSLAV 559 >UniRef50_B8FAB3 Pyruvate carboxyltransferase n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FAB3_DESAA Length = 374 Score = 331 bits (849), Expect = 4e-89, Method: Composition-based stats. Identities = 114/369 (30%), Positives = 186/369 (50%), Gaps = 11/369 (2%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V I DTTLRDGEQA + +EK+ +A+ L++ VD +EVG P P + ++ IA Sbjct: 7 VHIIDTTLRDGEQAPGVAFDKREKIALAMMLDQAHVDELEVGIPAMGPAAQDEIKAIAGL 66 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 + + A R ++ DID + + +H S +H+ + T V+ + Sbjct: 67 NPDCLLTAWCRALKDDIDQSL----LCNVTGVHISFPVSDIHLEA-MGKTRSWVLNQLSV 121 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 ++ A V +DA R +A L + V +A GA + I DTVG P + ++ Sbjct: 122 LIPYALQRFSRVSVGAQDAFRADMAFLEQFVHSANLRGAHRVRIADTVGLARPSQVENMV 181 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 L + + + H H+DLG+A N++AA+ AGA+ V +NG+GERAGN LE+V Sbjct: 182 HVLSKAAGKM---ALEFHGHNDLGMATANTIAAIEAGAQAVSVTVNGLGERAGNAPLEQV 238 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 ++A + + T ++ + + + V++ N PIPA++ I G F H SGIH G+ Sbjct: 239 VVA---AGTLDSRSTCVDARRLSEICRYVAEAVNRPIPADQPITGQAVFTHESGIHCAGI 295 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 LKN + Y+ PE++G + QL + SG ++H + + G + E ++L A A Sbjct: 296 LKNPDTYQPFNPETVGRERAQLVIGRHSGSGMIRHVLAKAGVRLEEGKTESLMAAVRMEA 355 Query: 365 DKKGQVFDY 373 KK V Sbjct: 356 LKKRSVLSP 364 >UniRef50_C1AUX2 2-isopropylmalate synthase n=8 Tax=Bacteria RepID=C1AUX2_RHOOB Length = 570 Score = 330 bits (847), Expect = 6e-89, Method: Composition-based stats. Identities = 109/530 (20%), Positives = 195/530 (36%), Gaps = 45/530 (8%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 + + LRDG QAL + + K + L +G +EVG+P +S DF+ V+ + Sbjct: 40 TTAPLWVPVDLRDGNQALAEPMDPERKRRFFELLISIGYKEIEVGYPSASQTDFDFVRDL 99 Query: 62 ARQ---VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE- 117 R + + + I ES++ +H + AT+P + L Sbjct: 100 VRLDLVPDDVTIVVFTAARDDLIARTYESVEGLPNVVVHMYTATAPTWRSVVLGKDRKAL 159 Query: 118 ---VIERAIYMVKRARNY-TDDVEFSCEDAGRTPIADLARVVEAAINAG------ATTIN 167 + + A + + A + EFS E T V + N Sbjct: 160 HRLIFDAAQEVARGAGDRPGLRFEFSPEVFNLTEPDFALEVCNSLTRLWDASPDRPVIHN 219 Query: 168 IPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEG 227 +P TV + P +A I ++ + + + I+SVH H+D G V + AV AGA++VEG Sbjct: 220 LPATVEVSTPNVYADQIEYMHRHLEDRESVILSVHPHNDRGTGVACAELAVLAGAQRVEG 279 Query: 228 AMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAI 287 + G GER GN L + + + + V I+ +I + V +P+ Sbjct: 280 CLFGNGERTGNVDLVTLALNLHAQG----VDPMIDLSDIDAVRRTVEYCNRIPVHERHPY 335 Query: 288 VGSGAFAHSSGIHQDGVLKNRE--------------------NYEIMTPESIGLNQI-QL 326 G + SG HQD + K Y + P +G + + Sbjct: 336 GGDLVYTAFSGTHQDAIKKGFAEHRASAEAAGLDPGSAPWAVPYLPIDPADVGRDYQAVI 395 Query: 327 NLTSRSGRAAVKHRMD-EMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQ 385 + S+SG+ + H + E G + + AD G + F Sbjct: 396 RINSQSGKGGIAHLLQSEYGITLPRRLQIDFAAKVQEAADSSGLEITAEELWTLF---CA 452 Query: 386 EEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVE 445 E L +SV+ G + V + A GPV+A+ + + +V+ Sbjct: 453 EYGYRGGLGRWSVEHGPDGDRLFVV-FDVDGAEASGEAVAAGPVEAMTRVLTS-KGVDVD 510 Query: 446 LVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHV 495 ++ + ++ G D+ + R G+G + S+ +A+ Sbjct: 511 VLSLTQHSQRSGSDSAAITLAECSVGERTVWGMGSHQSVTASAIRAVYAA 560 >UniRef50_Q56216 2-isopropylmalate synthase (Fragment) n=1 Tax=Thermus thermophilus RepID=LEU1_THETH Length = 331 Score = 330 bits (846), Expect = 8e-89, Method: Composition-based stats. Identities = 135/313 (43%), Positives = 186/313 (59%), Gaps = 2/313 (0%) Query: 188 YERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMA 247 + V +IS HTHDDLG+A N+LA V GA Q+E +NGIGERAGNC+LEEV+MA Sbjct: 1 RDEVVRGRDVVISTHTHDDLGMATANALAGVENGAGQIECTINGIGERAGNCALEEVVMA 60 Query: 248 IKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKN 307 + VR+D +T IN +EI+R S+LV + MP+P NKAIVG AFAH SGIHQDGV+K+ Sbjct: 61 LYVRRDWYKAYTRINTREIYRVSRLVERYTGMPVPPNKAIVGDNAFAHESGIHQDGVIKH 120 Query: 308 RENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGY-KESEYNLDNLYDAFLKLADK 366 R YEIM E IG L L SGRAA K ++++GY SE + L+ F ++A+K Sbjct: 121 RATYEIMDAELIGRRPAVLVLGKHSGRAAFKKALEDLGYKDLSEEEVKKLFARFKEIAEK 180 Query: 367 KGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGN 426 KG + +L+AL ++ F+L++ SGS + TA VK+ + + G+ Sbjct: 181 KGPLSAEELQALVESEREPTSH-FFQLEHVQFFSGSGLLPTATVKVKTPDGERLATHTGD 239 Query: 427 GPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVE 486 GPVDAVY+AI EL Y + A +ALGQV + + GVG++ DI+E Sbjct: 240 GPVDAVYKAIQEAIGLRPELELYRVEAITGSTEALGQVTVRLRLGELQAVGVGVSPDIIE 299 Query: 487 SSAKAMVHVLNNI 499 +SA A + + Sbjct: 300 ASALAFLDAAGKL 312 >UniRef50_B9LUZ7 Pyruvate carboxyltransferase n=1 Tax=Halorubrum lacusprofundi ATCC 49239 RepID=B9LUZ7_HALLT Length = 387 Score = 330 bits (846), Expect = 8e-89, Method: Composition-based stats. Identities = 146/391 (37%), Positives = 216/391 (55%), Gaps = 15/391 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V IFDTTLRDGEQ+ + S S EK +IA L+ M V+E GFPV+S +FE+V IA Sbjct: 10 VRIFDTTLRDGEQSPRTSFSYDEKRRIAATLDDMNTHVIEAGFPVNSDAEFEAVSDIA-A 68 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 N+ VC LAR VE DID A +S +H F++TS + + + +T E +RA+ Sbjct: 69 ATNTTVCGLARVVEGDIDAAIDS----GVEMVHVFVSTSDVQLEDSMHATRQEAKQRAVA 124 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 V++ ++ + FS DA RT L +VEA +AG INIPDT G MP F + Sbjct: 125 AVEQVKDAGVECMFSPMDATRTDPDYLREIVEAVSDAGTDWINIPDTCGVAMPTSFGKTV 184 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + N A + VHTHDD G+A N++ GA Q + ++NGIGERAGN + EEV Sbjct: 185 KAVV----NATDARVDVHTHDDFGMAAANAVMGFENGAEQAQVSVNGIGERAGNAAYEEV 240 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 +MA++ V T I+ +I + +++V + ++P+PANK + G AFAH SGIH GV Sbjct: 241 VMAVESVYG---VDTGIDTTQITKLARIVEEASDIPVPANKPVTGRNAFAHESGIHAAGV 297 Query: 305 LKNRENYE--IMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 ++N + +E +MTPE +G + + L +G +V+ + E G+ ++ + + + Sbjct: 298 IENADTFETGVMTPEMVGAER-EFVLGKHTGTHSVRKHLVEAGFDPTDSEVRRITKRVKE 356 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRL 393 K QV D+E A E E R+ Sbjct: 357 YGSGKRQVTAGDVERFAEEADIDREEEEVRI 387 >UniRef50_C8WE03 Homocitrate synthase n=3 Tax=Zymomonas mobilis RepID=C8WE03_ZYMMN Length = 402 Score = 325 bits (834), Expect = 2e-87, Method: Composition-based stats. Identities = 137/388 (35%), Positives = 201/388 (51%), Gaps = 13/388 (3%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + +II DTTLRDGEQA + ++ EKL IA AL+ GVD +E G P + E+++ I Sbjct: 7 KHLIINDTTLRDGEQAPGVAFTLSEKLHIAKALDEAGVDEIEAGIPAMGASEIEAIRQIV 66 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKL-RSTLDEVIER 121 +Q + +RV R D+D A E+ A +H I++SP +A K + +++ Sbjct: 67 QQSQTARVIPWCRMKISDVDKALET----GAKTVHLSISSSPFQMAAKFPDLSAADILGL 122 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 ++ A++ DV EDA R I+ L ++ AGA I DT+G PF Sbjct: 123 CQKVISYAKDRGLDVSVGAEDASRAEISFLTDLLGVIEEAGAFRIRFADTLGILDPFATY 182 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 IIS L++ I I H HDDLGLA NSLAA+ AGA+ + G+GERAGN L Sbjct: 183 EIISQLHQ----ISPLDIEFHGHDDLGLATANSLAAIKAGAKGASVTVLGLGERAGNAPL 238 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 E+V++A I T I ++++ +Q V+Q IP +KAIVG F H SGIH Sbjct: 239 EQVVIA---ASHIAGKETRILPEKLYNLAQYVAQAAGRTIPPDKAIVGEAVFQHESGIHV 295 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 G+L+N +YE + PE +G + ++ L SGRAA++H + +G K E + NL A Sbjct: 296 AGLLRNPASYEALNPEKLGRQR-EIVLGKHSGRAAIRHALSLLGIKAQEDMIQNLLAAVK 354 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPE 389 A + + AL +P Sbjct: 355 MQASHQKRAIGLSEIALIHQNFTHTQPN 382 >UniRef50_C1SID8 Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SID8_9BACT Length = 376 Score = 325 bits (834), Expect = 2e-87, Method: Composition-based stats. Identities = 118/366 (32%), Positives = 176/366 (48%), Gaps = 12/366 (3%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 II DTTLRDGEQ + S KEKL I L+ +GV +E G PV + ++I Sbjct: 2 IIDDTTLRDGEQTPGVAFSRKEKLTIVKHLDAIGVQEIEAGIPVMGLAESRMFESIMELG 61 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 ++R+ A R + D+ + A A I + S + I TKL T ++++ + Sbjct: 62 LDARIIAWNRALIGDVQASI----AAGANSIEISLPMSDVQINTKLNKTRGWILDQVKSV 117 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 + N+ + EDA R LA + GA DTVG PF+ + + Sbjct: 118 LDFCANHDLYISVGGEDASRADFDFLAEYIRTIEAHGADRFRFCDTVGILDPFKTYELTA 177 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245 + I I +HTH+D G+A N+LAAV AGA V + G+GERAGN LEE+I Sbjct: 178 KIR----EITSMDIEIHTHNDFGMATANALAAVRAGATHVNTTVIGLGERAGNAPLEEII 233 Query: 246 MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVL 305 MA + + + A + + + S+ V+Q + + ++G F H SGIH DGVL Sbjct: 234 MA---SRHVYGMDDAFDTKTMRSLSEYVAQAAGRNLDPQRPVIGEFMFTHESGIHTDGVL 290 Query: 306 KNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLAD 365 KN +NYE P + + + L ++SG A +K+ +++ G Y L L KLA Sbjct: 291 KNPKNYEAFDPAELNMQRN-LVFGNQSGLAVLKYILEQEGIVLESYQLTGLLHEAKKLAR 349 Query: 366 KKGQVF 371 K V Sbjct: 350 KNKAVL 355 >UniRef50_Q0ZQ46 FrbC n=3 Tax=Bacteria RepID=Q0ZQ46_9ACTO Length = 373 Score = 324 bits (831), Expect = 5e-87, Method: Composition-based stats. Identities = 104/380 (27%), Positives = 177/380 (46%), Gaps = 12/380 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M +++ DTTLRDGEQ + S + K I AL GV +E+G P + + +++ Sbjct: 1 MRNDLVLEDTTLRDGEQTPGVAFSKETKTAILNALIEAGVTSIEIGIPAMGGEELDFIKS 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 + + +R+ R V +D++ + + +H + TS H+ +R ++ Sbjct: 61 VVDRQDEARLVVWHRGVREDVERSLD----LGFTSVHVGLPTSAGHLKASVRKDRTWLLA 116 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 A MVK A++ V S ED RT I+ L AGA + + DTVG P + Sbjct: 117 TARDMVKMAKDRGAFVSISAEDIARTEISFLQEYAGVVAEAGADRLRLSDTVGLLGPEAY 176 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 ++ + + H H+D GLA N+LA + AGAR +N IGERAG Sbjct: 177 GERVAAVLSAA----DIDVQCHAHNDFGLATANTLAGLKAGARYFHVTVNAIGERAGMAD 232 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 L +V++A+K D I+ ++ + S+LV++ + + I G FAH SGIH Sbjct: 233 LAQVVVALKKLYDR---DLGIDLTKLKKVSRLVAEAAGHQVLPWQPITGDNVFAHESGIH 289 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 +G+ ++ ++E PE +G + + L SGRA V +++ G E L + + Sbjct: 290 ANGMFRDTSSFEPFPPEHVGGER-RYVLGKHSGRALVAWALEQEGITPREELLPHCLEEV 348 Query: 361 LKLADKKGQVFDYDLEALAF 380 L+ + G ++ + Sbjct: 349 RALSIRIGGAVSHEQLVEIY 368 >UniRef50_Q6KZ01 2-isopropylmalate synthase n=1 Tax=Picrophilus torridus RepID=Q6KZ01_PICTO Length = 375 Score = 323 bits (829), Expect = 8e-87, Method: Composition-based stats. Identities = 121/388 (31%), Positives = 190/388 (48%), Gaps = 19/388 (4%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + + D+TLR+GEQ S S+ +++IA AL GV ++E G P S +S+++I Sbjct: 2 IGLLDSTLREGEQTPGVSFSMDARVEIARALSDAGVSMIEAGHPAVSETVLKSIKSIMEL 61 Query: 65 ----VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 + S + A +R V DIDVAA I F S +H+ K T ++ I Sbjct: 62 KSSGIIRSTIVAHSRAVRSDIDVAA----SLNIDMIAIFYGISDLHLKYKTLKTREDAIR 117 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 + + AR+Y +V F+ EDA RT L V AA +AGA I+I DTVG P Sbjct: 118 IIVDSIDYARSYGLNVRFTAEDATRTDYNYLLDVARAARDAGAKRISIADTVGILNPDTS 177 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 + + + ++ +H H+DLG+AV NS+AA AGA + +NG+GER+G Sbjct: 178 YKLFKMI---IKDVKNVEFDIHAHNDLGMAVANSIAAYRAGATIIHSTVNGLGERSGITP 234 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 + + A+K + I+ + ++ S LV + + +P N + G AF H SG+H Sbjct: 235 TQIIGPALKYHYN----EAVIDLKRLYSLSNLVEKYSGVMVPYNYPVTGKNAFTHKSGVH 290 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 G++ E YE M P G + ++S SGR AV R+ E+G ++ +L L Sbjct: 291 IAGIINKPETYEFMDPCLFGNKRY-YTISSYSGRHAVITRLQELGISLNDEHLKILMKMI 349 Query: 361 LKLADKKGQVFDYDLEALAFIGKQQEEP 388 K ++ D +L A+A K+ Sbjct: 350 KN---KNRELNDDELYAMAESIKRSAVS 374 >UniRef50_A6FCI3 2-isopropylmalate synthase n=1 Tax=Moritella sp. PE36 RepID=A6FCI3_9GAMM Length = 387 Score = 322 bits (826), Expect = 2e-86, Method: Composition-based stats. Identities = 119/384 (30%), Positives = 198/384 (51%), Gaps = 4/384 (1%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ I DTTLRDGEQA + ++ ++KL++AL LE GVD +E GFP SS D+E+ + I+ Sbjct: 2 KKISILDTTLRDGEQAPENAMDPEKKLKMALMLEECGVDHIETGFPASSKFDYEATKLIS 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 ++V S + +R + D+ ++ ES + I S +H+ K + + IE Sbjct: 62 KEVTQSGIATFSRTLTSDVQLSLESGGREKNHTIQMVATGSDLHLKNKRNISRSQAIEEV 121 Query: 123 IYMVKRARNY-TDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 I VK A+ + EDA R + + EAA+ AGA I + DT GY P EF Sbjct: 122 INTVKFAKQNSDCRIAVGIEDASRADFDFMGEITEAAVFAGAHQIILADTTGYATPSEFK 181 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 +I + + D IS H H+DLGLA N+LA + GA +V+ + GIGERAGN SL Sbjct: 182 KLIQFIRSKTG--DGISISTHCHNDLGLAHANTLAGIEGGADEVQVTLGGIGERAGNASL 239 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 E + + + + + T I ++++ Q + + IP N+ + G+ AF+ ++GIHQ Sbjct: 240 EMIASTLFFKPECYSSFTDIKLDKLYKVYQELCSEIGLDIPRNQPVFGTYAFSTAAGIHQ 299 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 GVL N + YE + P+ + + ++ SG++ +K+ + + L+ LY + Sbjct: 300 QGVLANPDTYEFVKPDVFNRER-EFFVSRHSGKSIIKYILSNKAMDQDPKLLETLYANCI 358 Query: 362 KLADKKGQVFDYDLEALAFIGKQQ 385 + + +LE + Sbjct: 359 SSRAENSCLSMIELEFEIDKFMKT 382 >UniRef50_C6HVD7 2-isopropylmalate synthase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HVD7_9BACT Length = 392 Score = 322 bits (826), Expect = 2e-86, Method: Composition-based stats. Identities = 116/378 (30%), Positives = 176/378 (46%), Gaps = 12/378 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + DTTLRDG Q+ K+ + L R+GV +EVG P + E ++ + Sbjct: 12 PVFVDTTLRDGGQSPGVFFDRPTKMAVVTTLSRIGVKEIEVGSPCLGEREHEDLKVLLSL 71 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 + + R VE+D D A R+H TS +H+A R +E ++R Sbjct: 72 PVPAEIFPWLRPVEEDFDAALR----LGFRRVHISFPTSDLHMAVLRRVGREETLDRVRR 127 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 V R V EDA R + L +++ +AG + DTVG P E + I Sbjct: 128 AVCRMVEEGCRVSVGLEDASRAEMGFLRDIIKTVQDAGGIRVRYCDTVGRHHPLEMSERI 187 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 S L I VH H+DLGLA N++AA HAGA + + G+GERAGN ++EEV Sbjct: 188 SALASC-----GLPIEVHCHNDLGLATANTVAAFHAGAAFLSTTVTGVGERAGNAAMEEV 242 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 A+ + T I+ + S+ + + + IVGS F HSSGIH DGV Sbjct: 243 AFALAFSGEGG--ETGIDFPGLAHISRWLYTAIGRTLSPFRPIVGSRIFHHSSGIHVDGV 300 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 +K NYE+ PE +GL + ++ +T ++GRA +K+ ++ MGY+ + LD L + Sbjct: 301 IKEPSNYELFPPELVGLKR-KIIVTHQTGRAGIKNVLERMGYRPTSEVLDRLVPVIREEG 359 Query: 365 DKKGQVFDYDLEALAFIG 382 + F+ Sbjct: 360 WSMKGIVPAQTILRHFME 377 >UniRef50_A9A1L0 Pyruvate carboxyltransferase n=6 Tax=Thaumarchaeota RepID=A9A1L0_NITMS Length = 393 Score = 321 bits (824), Expect = 3e-86, Method: Composition-based stats. Identities = 100/363 (27%), Positives = 182/363 (50%), Gaps = 13/363 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 +++ + D+TLR+GEQ S + K+++QIA L+ GVD +E+ PV S E+ +TI Sbjct: 24 PKKIRVLDSTLREGEQHPGVSFTNKQRIQIAWMLDYFGVDQIEI-SPVVSNDHKEATKTI 82 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 +Q + + + R +++DIDV+ + +A ++ S +H+ KLR + ++ +ER Sbjct: 83 IKQGLKADIVSHGRALKEDIDVSLD----CDAKWCAAYLGISDIHLKDKLRISREDAMER 138 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 A+ V+ A+++ + F+ ED R L +V +A AG I++PDTVG P Sbjct: 139 AVETVEYAKSHGLKIRFTVEDGSRAEPEFLLKVCKAIEEAGVDRISLPDTVGILRPIGMY 198 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 + + + + + H H+D+G AV N+ +A AG Q+ ++GIGER G L Sbjct: 199 NFVKKVRDSI----DVPLDAHVHNDIGFAVANAFSACDAGVDQIHTTIDGIGERTGIPPL 254 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EV +A+ N + S+L+ + + +K IVGS A+ H +G H Sbjct: 255 AEVAVALTYLYKSPN---DFRLDMLLDLSRLIEEYTTIKPYDSKPIVGSSAYKHKAGTHL 311 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 +L+N YE + P ++G N+ ++ +G+ + M +G + + + + Sbjct: 312 AAILRNPAAYEPIPPRAVG-NRRRIVFGELAGKTGAAYLMSLLGLDKDDESAKAVAAGLK 370 Query: 362 KLA 364 L Sbjct: 371 GLR 373 >UniRef50_P54610 Homocitrate synthase n=6 Tax=Frankia RepID=NIFV_FRASP Length = 401 Score = 320 bits (820), Expect = 8e-86, Method: Composition-based stats. Identities = 113/370 (30%), Positives = 165/370 (44%), Gaps = 17/370 (4%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V DTTLRDGEQA + + EKL IA AL+ +GV +E G P + + ++ I Sbjct: 22 VRFCDTTLRDGEQAPGVAFTAAEKLAIAGALDAIGVHQIEAGIPGMGVTERDVLREILAT 81 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 + + R +D+ E+ H I S +H+ +KL R Sbjct: 82 DPKAEIVGWCRADHRDV----EAAASCGLVTAHLTIPVSDLHLKSKLERDRAWARRRVRD 137 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 V + V EDA R A + + + G T + DTVG P + Sbjct: 138 CVVDGTDRGMRVSVGFEDASRADDAFVTDLAGELRDVGVTRLRWADTVGLLDPVSAYDRL 197 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 L VP +H HDD GLA N++AAV AG V + G+GERAGN +EEV Sbjct: 198 GRLVRAVPG----PWEIHAHDDFGLATANTIAAVQAGFTWVSTTVLGLGERAGNAPIEEV 253 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA-NKAIVGSGAFAHSSGIHQDG 303 MA++ + ++ +QLV P+PA KA+VG FAH SGIH G Sbjct: 254 AMALRHLLKLPI---DLDTTSFRTLAQLV---VGWPLPAGKKAVVGESVFAHESGIHVHG 307 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 +L++ YE PE G + L + SGRA+++H +++ G E L+ L + Sbjct: 308 ILRHPATYEPFDPEVGGRRR--LTVGKHSGRASLRHALEQCGITAEESELEPLVEQVRLA 365 Query: 364 ADKKGQVFDY 373 A + + D Sbjct: 366 ATRHKRGLDS 375 >UniRef50_Q52070 Homocitrate synthase n=9 Tax=Gammaproteobacteria RepID=NIFV_ENTAG Length = 400 Score = 320 bits (820), Expect = 8e-86, Method: Composition-based stats. Identities = 111/394 (28%), Positives = 175/394 (44%), Gaps = 13/394 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 VII DTTLRDGEQ+ + EKL+IA AL GV +E G P + + + Sbjct: 15 PMAVIINDTTLRDGEQSPGVAFRASEKLEIAQALVNAGVRELEAGTPALGEEECVRLAIL 74 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 RQ+ ++ + + R +I +A + + S + KL VI Sbjct: 75 RRQLPDTVMMSWCRMNSAEIHDSAR----VGMDWVDISVPASDLLREQKLHRPWPAVIAS 130 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 +V+ A V CEDA R+ L + E A + G + DT+G PF Sbjct: 131 LKPLVQLAHRLGMRVCMGCEDASRSADETLHMLAEVAADLGIERMRFADTLGILDPFSTF 190 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 IS L + + +H H+DLG+A N+LAAV AGA V + G+GERAGN +L Sbjct: 191 TRISALRQHWHGG----LEIHAHNDLGMATANTLAAVRAGATHVNTTVLGLGERAGNAAL 246 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 E V +++ L++ I+ E+ +LV+ I +VG F H SG+H Sbjct: 247 ESVTLSLDR---CLHLDCGIDFTELPALCRLVAAAAGRTIDVQHPLVGGQVFTHESGLHV 303 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 +L++ +Y+ + P +G + L L SGR AV +GY SE + Sbjct: 304 AALLRDPRSYQGIDPSLVGR-EFNLVLGKHSGRQAVSGICARLGYILSETQTLLMLQEVK 362 Query: 362 KLADKKGQ-VFDYDLEALAFIGKQQEEPEHFRLD 394 + A+ + + ++ A+ + + P +L Sbjct: 363 RFAEHFKRNPGEDEVIAMCQMRMDDQIPFEGQLQ 396 >UniRef50_Q9V1J1 2-isopropylmalate synthase 2 n=5 Tax=Thermococcaceae RepID=LEU12_PYRAB Length = 361 Score = 318 bits (815), Expect = 3e-85, Method: Composition-based stats. Identities = 102/360 (28%), Positives = 177/360 (49%), Gaps = 15/360 (4%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 ++ D+TLR+GEQ + + +++L+IA+AL+ +GVD +E+G P S F ++ IA Q Sbjct: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 N + A +R + +DID ++ + F S + + R TLD +E+ Sbjct: 61 LNVELLAHSRALIEDIDYVLKT----GVDWVGIFFCLSEACLRKRFRITLDHALEKISRA 116 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 ++ A+++ V F+ ED RT A+L R + A I++ DT G T P F ++ Sbjct: 117 IEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVK 176 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245 + ++VH H+DLGLA+ N++ + AGA V+ +NG+GERAG L ++I Sbjct: 177 KIVN-----FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQII 231 Query: 246 MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVL 305 + I ++R S LVS+I + N IVG AF H +G+H VL Sbjct: 232 TVLYYHYGIK----KYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVL 287 Query: 306 KNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLAD 365 K+ YE + E G + +G+ +++ +++ G + + +L + Sbjct: 288 KDPRFYEFLPAEVFGRERTIYV-DRYAGKDTIRYYLEKFGIR-DHGIVTSLLRKVKSSRE 345 >UniRef50_A7IBL6 Homocitrate synthase n=19 Tax=Proteobacteria RepID=A7IBL6_XANP2 Length = 415 Score = 318 bits (814), Expect = 4e-85, Method: Composition-based stats. Identities = 124/386 (32%), Positives = 179/386 (46%), Gaps = 12/386 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 ++ + DTTLRDGEQA + + +EK++IA AL GV +E G P + E++++I Sbjct: 30 ARTAFLNDTTLRDGEQAPGVAFTRREKIEIAEALAAAGVPEIEAGTPAMGDEEIETLRSI 89 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 RV A R E+D + A ++ I TS + KL D + Sbjct: 90 VSLKLPLRVAAWCRMSEED----LFAAVSAGVTYVNLSIPTSDRQLKGKLNRDRDWALGA 145 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 ++V A CEDA R L +V E A AGA + + DT+G PF Sbjct: 146 LRHVVTLATKLGFTAAVGCEDASRADPDFLCKVAEVAKEAGAFRLRLADTLGVLDPFSAY 205 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 ++ RV N I H HDDLGLA N+LAAV GAR + G+GERAGN +L Sbjct: 206 ALVR----RVANATDLEIEFHAHDDLGLATANTLAAVTGGARHASVTVAGLGERAGNAAL 261 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EEV +A++ T I+ + +Q V + P+P KAIVG F H SGIH Sbjct: 262 EEVAIALRQTA---RSETGIDPHALRPLAQKVMEAAGRPMPRTKAIVGEDIFTHESGIHV 318 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 G+LK+R YE ++PE +G + ++ L SG AA+ + + G E + Sbjct: 319 SGLLKDRGTYEALSPEMLGRS-HRVVLGKHSGLAAILKALSDQGLAVDEARGRAILARVR 377 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEE 387 A + D+ + EE Sbjct: 378 DFAIRSKNSVSPDVLRRFYEDSFTEE 403 >UniRef50_B6YRB4 Homocitrate synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YRB4_AZOPC Length = 374 Score = 317 bits (813), Expect = 6e-85, Method: Composition-based stats. Identities = 99/378 (26%), Positives = 169/378 (44%), Gaps = 12/378 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + D+TLRDGEQA KEK+++A L +G+D +EVG P + ++Q I R Sbjct: 5 PFLIDSTLRDGEQAPNVVFLRKEKIRLAQMLSEIGIDEIEVGIPAMGEDECNTIQNIVRL 64 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 + +R ++KDI E A IH S + + + T V + Sbjct: 65 KLRPIISVWSRAIKKDI----EQASTLGATCIHIAFPLSDIQLQA-INKTYGWVEDTFSK 119 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 ++ A+N + V +DA R PI + + ++ A G + DTVG P + II Sbjct: 120 TIQCAKNLFERVSVGAQDASRCPIDRVIQFIDMAEKYGVFRVRFADTVGILTPIQTIEII 179 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + ++ N+ I H H+D G+A N+L A GA + +NG+GERAGN +LEE+ Sbjct: 180 RTIKKKKTNM---NIDFHAHNDFGMATANALTAYQVGANSLSVTINGLGERAGNAALEEI 236 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 +M ++ T + ++ + VS I P+P KAI G A +H SGIH + Sbjct: 237 LMGLRQING----KTKYDLSTLFDLCRYVSVISGRPLPDGKAICGKFAVSHESGIHTQAI 292 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 L + ++ + +G + + SG+ A+ + + E + L + A Sbjct: 293 LSDILAFQPFNGDILGREKCSILFGKHSGKRAIIDLLKRQNIEVEESRISLLIEKIRNTA 352 Query: 365 DKKGQVFDYDLEALAFIG 382 + + + ++ Sbjct: 353 NVIRRSLSSEEVVDLYLE 370 >UniRef50_C1FHL1 2-isopropylmalate synthase n=2 Tax=cellular organisms RepID=C1FHL1_9CHLO Length = 662 Score = 317 bits (813), Expect = 6e-85, Method: Composition-based stats. Identities = 121/574 (21%), Positives = 214/574 (37%), Gaps = 82/574 (14%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 V+ +DTTLRDG Q + SL+ +KL +A L +GV +E G+P S+P D E Sbjct: 63 DVVCYDTTLRDGSQQVGISLTCDDKLAVAEHLVGLGVAYIEGGYPGSNPKDVEFFSRWTS 122 Query: 64 QVK-------NSRVCALA----RCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLR 112 +++ A R V D D ++L A + L Sbjct: 123 SGLADRAAAGGTKLAAFGMTRRRGVTADDDEGLKALTDCPAPCVCIVAKAWDEQCEKVLG 182 Query: 113 STLDEVIERAIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIP 169 + +E I V +V CE + + AA +GA + + Sbjct: 183 VSPEENIAMIEESVAHLVAAGKEVLVDCEHYFDGRKANPEFAVKCAAAAAKSGAKFVVLC 242 Query: 170 DTVGYTMPFEFAGIISGLYERVPNID-KAIISVHTHDDLGLAVGNSLAAVHAGARQVEGA 228 DT G T+P++ + E V + +H H+D LAV NS+AAV GA V+G Sbjct: 243 DTNGGTLPWDVEEFTREVKEAVDATGADCSVGIHCHNDTSLAVANSIAAVRGGATMVQGC 302 Query: 229 MNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIV 288 +NG GER GN L V ++++ + + Q + + S V+++C+ + + Sbjct: 303 VNGYGERTGNADLLVVAANLELKMGRTALPEG-SLQRLTQVSAAVAKLCSQHQDPRQPYM 361 Query: 289 GSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE 348 GS AFAH G+H + K +Y + P +G N+ + ++ SGR + G + Sbjct: 362 GSSAFAHKGGLHVAALQKMPASYNHIVPTLVG-NEARSVISELSGRGNILSAAMASGREV 420 Query: 349 SEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQE--EPEHFRLDYFSVQSGSNDIA 406 S+ + L + +G V + ++ + ++ + F + F+V + ++ Sbjct: 421 SKETAAQVLSQIKDL-ESRGFVLEDAGASVDILFRRADPNYRAPFNVLEFNVTASNSSFG 479 Query: 407 TAAVK-LACGEEVKAE-------------------------------------------- 421 L G + + + Sbjct: 480 GFTPNDLLVGGDERLQDVLPEDELEAPFTHPQQAGYKKGSVAVNQVVVKVDVFDNDTTPA 539 Query: 422 -------AANGNGPVDAVYQAINRITE------YNVELVKYSLTAKGHGKDALGQVDIVA 468 A GNGPV+A+ A+ + L Y + + + Sbjct: 540 SRNTQLCVAEGNGPVNALANALRLSLTDKFPQLKQIHLQDYKVDLLSTAGTSAAVTRVTM 599 Query: 469 NYNGR----RFHGVGLATDIVESSAKAMVHVLNN 498 ++ R + VG I+E+S +A+V + Sbjct: 600 DFADRDTDITWRTVGAHASIIEASFRALVDGMEY 633 >UniRef50_UPI000038E0D5 2-isopropylmalate synthase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0D5 Length = 377 Score = 315 bits (808), Expect = 2e-84, Method: Composition-based stats. Identities = 107/366 (29%), Positives = 178/366 (48%), Gaps = 17/366 (4%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M +V I D+TLR+GEQ + ++++IA L V ++E G P+ SP + +++ Sbjct: 1 MPLKVGILDSTLREGEQTPGVLFNKNQRIEIAQLLSDAHVAMIEAGHPLVSPDIYSAIKE 60 Query: 61 I----ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 I A + NS + A +R V DID AA RI F S +H+ K + Sbjct: 61 IMDMKASGMINSEIIAHSRAVNSDIDSAA----SLGVDRIAIFYGVSDIHLDNKTHRSRT 116 Query: 117 EVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTM 176 E ++ + A + V F+ EDA RT I L VV A++AGA ++I DT+G Sbjct: 117 EALDIIYDSISYASSTGIPVRFTAEDASRTDINFLRNVVRTAVDAGADRVSIADTLGILT 176 Query: 177 PFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERA 236 P + A ++ + +I H H+D+G+A+ N LAA +GA + +NG+GER Sbjct: 177 PEKTA----YIFNNLSDIKGVEYDFHGHNDMGMALANGLAAAESGATIIHSTVNGLGERV 232 Query: 237 GNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHS 296 G + + + + + AIN + S+L+ + + +P N + GS AF H Sbjct: 233 GIIPTQALGVLLNYHLGVD----AINLLSLKPLSELIEKYSGITMPPNYPVTGSTAFTHK 288 Query: 297 SGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNL 356 SG+H DG+++N YE M P +GL + SG+ A++ ++ MG + + + Sbjct: 289 SGVHVDGIIRNPGTYEFMDPSRLGLQHS-FTIDKYSGKHALREKLANMGINADDNKISYM 347 Query: 357 YDAFLK 362 + Sbjct: 348 LEKIKN 353 >UniRef50_Q12122 Homocitrate synthase, mitochondrial n=109 Tax=cellular organisms RepID=HOSM_YEAST Length = 440 Score = 315 bits (808), Expect = 2e-84, Method: Composition-based stats. Identities = 100/386 (25%), Positives = 171/386 (44%), Gaps = 9/386 (2%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + + D+TLR+GEQ A ++K++IA AL+ GVD +E+ PV+S + + I Sbjct: 35 KNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAIC 94 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 + +++ RC D VA E+ + I TS ++ + + A Sbjct: 95 KLGLKAKILTHIRCHMDDARVAVET----GVDGVDVVIGTSKFLRQYSHGKDMNYIAKSA 150 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + +++ ++ ++ FS ED+ R+ + DL + + G + I DTVG P + Sbjct: 151 VEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYE 210 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 +I L V I H H+D G A+ N+ A+ GAR ++ ++ GIGER G L Sbjct: 211 LIRTLKSVV----SCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLG 266 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 + MA + V + +I LV+ + IP N I G AF H +GIH Sbjct: 267 GL-MARMIVAAPDYVRSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAK 325 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 +L N YEI+ P G+ + +G A+K R+D++ ++ + + K Sbjct: 326 AILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKSRVDQLNLNLTDDQIKEVTAKIKK 385 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEP 388 L D + D + + P Sbjct: 386 LGDVRPLNIDDVDSIIKDFHAELSTP 411 >UniRef50_C0W2B6 Alpha-isopropylmalate/homocitrate synthase family transferase n=1 Tax=Actinomyces urogenitalis DSM 15434 RepID=C0W2B6_9ACTO Length = 551 Score = 314 bits (804), Expect = 7e-84, Method: Composition-based stats. Identities = 137/537 (25%), Positives = 234/537 (43%), Gaps = 43/537 (8%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 ++ +V +DTTLRDG Q S +V++KL +A L+ +GV +E G+P + P D E Sbjct: 3 LTPRVATYDTTLRDGAQQQSVSFTVEDKLAVARILDHLGVTYIEAGWPGAIPKDTEFFAR 62 Query: 61 IARQVK--NSRVCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRST 114 A ++ +R+ A D L + A I + P H+ LR++ Sbjct: 63 AASELSLATARLVAFGSTCHPGTAAEKDPQLRGLLDSGAPVITIVAKSDPAHVERALRTS 122 Query: 115 LDEVIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDT 171 +E + V +V E D + A AGA+ + DT Sbjct: 123 GEENLRMVADSVGLLVAAGREVMVDLEHYVDGVARDPRYGIELALTAARAGASAVIPCDT 182 Query: 172 VGYTMPFEFAGIISGLYERV--PNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 G ++P A IS L + + ++ +HTHDD GLAV ++AAV AGARQV+G + Sbjct: 183 NGGSLPGTVAAEISRLRAALDAAGHEDCVVGIHTHDDSGLAVAAAMAAVEAGARQVQGCV 242 Query: 230 NGIGERAGNCSLEEVIMAIKVRKD-----ILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 NG GER GN +L +I ++++ + A E+ S+ V +I N Sbjct: 243 NGFGERTGNANLLTLIANLELKTGYQALAGDSQERARRLAELSAVSRTVGEIANRAPSGR 302 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEM 344 VGS AFAH +G+H + + Y+ + P +G N + + ++ +GRA+++ + E+ Sbjct: 303 LPYVGSKAFAHKAGLHASAIKVDPNLYQHVDPARVG-NTMTMLVSEMAGRASIELKAREL 361 Query: 345 GYKE-SEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQ--EEPEHFRLDYFSVQSG 401 G + + L +K + G +D + + +Q + P++FR++ + Sbjct: 362 GIETGGDKELLARVTEVVKGREAAGYAYDAADGSFELLLRQALGQLPQYFRVESWRASVT 421 Query: 402 SNDI---------------ATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITE----- 441 + + A V++ G A GNGPV+A+ A+ Sbjct: 422 ARPAAGQEILPEDGATVTDSEATVRMWVGGRRLAVLGEGNGPVNALDHALCDALATAYPE 481 Query: 442 -YNVELVKYSLTAKGH--GKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHV 495 EL + + G A+ +V I R + VG+ TDI+E+S +A+ Sbjct: 482 IRAFELTDFKVRILDSERGTHAIVRVLIDITDGERSWSTVGVGTDIIEASWEALTDG 538 >UniRef50_Q7M8U7 HOMOCITRATE SYTHASE 1 n=1 Tax=Wolinella succinogenes RepID=Q7M8U7_WOLSU Length = 376 Score = 313 bits (803), Expect = 9e-84, Method: Composition-based stats. Identities = 97/386 (25%), Positives = 164/386 (42%), Gaps = 12/386 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + I DTTLRDGEQA + + +EK +IA L G D +E+G P + E ++ I Sbjct: 2 ITINDTTLRDGEQAPTVAFTQEEKCEIAKLLYEAGADELEIGIPAMGEAEREDIRAILSL 61 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 R+ + R + D E+ + I S +A K R +V+ Sbjct: 62 GLPLRLMSWNRATQSD----LEASLACGMKAVDLSIPVSTKMVAAKFRGKYAKVLSNLEE 117 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 + A+ V ED R L V+ A+ GA + DTVG P + I Sbjct: 118 TLTIAKKEGLFVCVGMEDTSRANARFLKEVIALAMERGADRVRFCDTVGILTPLQTYRAI 177 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 L + +H H+D G+AV NS+A + AGA+ V + GIGERAGN E+V Sbjct: 178 RSLRRHCT----LPVEMHCHNDYGMAVANSIAGIEAGAQSVNTTVIGIGERAGNAGFEQV 233 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 ++++ + ++ + Q V++ + + +VGS F H SGIH DG Sbjct: 234 LLSLIGQFGQNRT---LDSTILKALVQKVAKAAGVALAPTAPVVGSRLFWHESGIHADGN 290 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 K+ YE +PE +G ++ + + SG A + + + + + +L ++ Sbjct: 291 QKSEGLYEPFSPELVGASR-EYPIGKHSGSANLIYHLKQFVPLIEKGEASDLLPLVREIV 349 Query: 365 DKKGQVFDYDLEALAFIGKQQEEPEH 390 K + ++ ++ + Sbjct: 350 TKNKKPLSAKELFCLYLSHKRHSQKE 375 >UniRef50_B0TW82 2-isopropylmalate synthase n=17 Tax=Francisella RepID=B0TW82_FRAP2 Length = 526 Score = 312 bits (799), Expect = 2e-83, Method: Composition-based stats. Identities = 131/523 (25%), Positives = 229/523 (43%), Gaps = 32/523 (6%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFE----SV 58 +++ IFDTTLRDG+Q+ A +S ++ + A ++ +DV+E GFP +S DFE Sbjct: 4 KKIYIFDTTLRDGQQSPGAGMSFEDNIAYADLANKLNIDVLEAGFPSASNTDFEIVNTIS 63 Query: 59 QTIARQVKNSRVCALARCVEKDIDVAAESLKVA---EAFRIHTFIATSPMHIATKLRS-- 113 + +A + N + L + + +++ ++L+ + R+H ++ P L S Sbjct: 64 KRMAEKNSNMIIAGLCQLRKNQVEITMDALRPSLAIGKARVHMYLPVDPNLAQASLGSKN 123 Query: 114 TLDEVIERAIYMVKRARNYTDDVEFSCEDAGRT--PIADLARVVEAAINAGATTINIPDT 171 ++ I+ ++K A + +VEFS E R + V AA++AG T IN PDT Sbjct: 124 DNEQNIKNVYELIKLASDQGFEVEFSAEGYSRLGDTFDYVTDVFRAAVSAGVTVINCPDT 183 Query: 172 VGYTMPFEFAGII--------SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAG-A 222 +G E + + P+ I S H H+DLGLA+ NS+ AV G A Sbjct: 184 IGGACERENDNYFVKNMTKHAEIIKKEFPD-KNIIWSAHCHNDLGLALENSMNAVFDGPA 242 Query: 223 RQVEGAMNGIGERAGNCSLEEVIM--AIKVRKDILNVHTAINHQEIWRTSQLVSQICNMP 280 QVEG +NG+GERAGN SLE+ +M + ++ + + IN S + + + Sbjct: 243 TQVEGCINGVGERAGNASLEQCVMFINLFGKQKDCHFYNDINIANFKTISDFIGKRM-LS 301 Query: 281 IPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHR 340 + I G + H+SG H + +L N Y+ PES+G N+I SG K Sbjct: 302 RQPHHPITGLNSARHTSGGHTNAILNNPLAYQPFHPESVG-NEISFIFGPLSGGNHAKKI 360 Query: 341 MDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQS 400 ++E GY + + + ++ + + L KQ + P H + + Sbjct: 361 IEENGYICDDKEKAAIAQQIKDIYHERRKGITDE--ELIQAYKQIKSPIHVSAIDYGKSN 418 Query: 401 GSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAK-GHGKD 459 G + + + N + A+ + I +V + Y + G + Sbjct: 419 GETYVELKGRFFGNTDYRITDRGE-NSALSALLKGIQEYIP-DVNISDYFSRSLKDAGIN 476 Query: 460 ALGQVDIVANYNGRR--FHGVGLATDIVESSAKAMVHVLNNIW 500 + + I+ G+ + DI SS KA++ N ++ Sbjct: 477 SKSETTIIIKTGENSPVVEGIAVDQDIEISSLKALITATNKLY 519 >UniRef50_C5QA64 2-isopropylmalate synthase n=1 Tax=Staphylococcus epidermidis BCM-HMP0060 RepID=C5QA64_STAEP Length = 390 Score = 309 bits (791), Expect = 2e-82, Method: Composition-based stats. Identities = 114/372 (30%), Positives = 195/372 (52%), Gaps = 5/372 (1%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 +++ DTTLRDGEQA SL EKL++AL LE+ G++ +E GFP SS DF S Q I+ Sbjct: 6 RKITFLDTTLRDGEQAPGNSLKHGEKLELALMLEKAGIETIETGFPASSKEDFISTQKIS 65 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 + +K S +R +DID++ ++ +E + S +H+ K + + + IE Sbjct: 66 KILKTSNFATFSRTKLEDIDLSIQAGGTSEKHILMLVATGSDLHLEKKRKMSRQDGIEEI 125 Query: 123 IYMVKRARNYTDD-VEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 V AR V EDA R + ++ A+ +GA I + DT GY MP + Sbjct: 126 KKSVVYAREKGIKNVAVGIEDASRADSKYVEELINVAVQSGANQIILADTTGYAMPNDIY 185 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 ++ + +SVH H+DLGLAV NS A+ AGA +++G + GIGERAGN S+ Sbjct: 186 DLVKLSKRCISK--SIKLSVHCHNDLGLAVINSYYAILAGADEIQGTIGGIGERAGNTSI 243 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 E+V+ I + +++ +N + ++ + +S+ ++ I G F+ ++GIHQ Sbjct: 244 EQVLALIHYKGKNKKIYSDVNKKNLYPIYEKLSEYIDLEENRTLPIFGKYVFSTAAGIHQ 303 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMG-YKESEYNLDNLYDAF 360 G+L + + YE + PE G + + + SG++ +K +++ + +D+LY+ + Sbjct: 304 QGILNDPKTYEFVLPEDWGRTR-EFYIDKHSGKSILKDVVEKQNATDIVKDKIDSLYNKY 362 Query: 361 LKLADKKGQVFD 372 + D+ D Sbjct: 363 IDNNDRTITYQD 374 >UniRef50_B5JMT2 HMGL-like domain protein n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JMT2_9BACT Length = 372 Score = 306 bits (785), Expect = 9e-82, Method: Composition-based stats. Identities = 106/382 (27%), Positives = 177/382 (46%), Gaps = 12/382 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 + DTTLRDGEQA + S+ EK IA L + G+ +EVG P + + ++ I Sbjct: 3 PDNRYLIDTTLRDGEQAAGVAFSLSEKKAIATLLSQTGIPEIEVGIPAMGECERQHIRAI 62 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 ++ + R+ R V +D+ A++S A H + SP+H+ + V+ Sbjct: 63 SQLDLDCRILTWGRAVREDLRAASKS----GADGFHFSLPASPLHLRI-WKKNERWVLRT 117 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 + K A + + +DA R L ++AA GA+ + I DT G P + Sbjct: 118 MSELAKEAADTFEYFSVGAQDASRADRDFLKLFIDAAQVLGASRVRIADTTGRLNPIDTL 177 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 + + + + H H+DLG+AV N+++A GA +NG+GERAGN +L Sbjct: 178 DLFCDITKNA----SIDLEFHAHNDLGMAVANTVSAFIGGATCASVTVNGLGERAGNAAL 233 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 EEV MA+K D + ++ ++ S V+ + NK + G GA +H SGIH Sbjct: 234 EEVSMALKHSTD---IDIPMDASHYYKLSDYVANASQRRLAWNKPVTGPGAHSHESGIHC 290 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 G+L + +YE ++PE IG ++ + + SG AAV ++G+ S L Sbjct: 291 KGLLTDSRSYETVSPEEIGQSRPEFAIGRHSGSAAVIAAAQKLGHTLSAKKATALLPLIR 350 Query: 362 KLADKKGQVFDYDLEALAFIGK 383 A+++G+ + Sbjct: 351 TAAEQRGRSLTASELSRLIEIH 372 >UniRef50_Q2GMU3 Putative uncharacterized protein n=1 Tax=Chaetomium globosum RepID=Q2GMU3_CHAGB Length = 828 Score = 304 bits (780), Expect = 4e-81, Method: Composition-based stats. Identities = 103/526 (19%), Positives = 193/526 (36%), Gaps = 63/526 (11%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +++ T LRDG QAL + + L +G +EVGFP SS DF+ Q Sbjct: 52 ITKPPRWLSTDLRDGNQALASPM----------MLVDIGFKEIEVGFPASSEMDFQFAQR 101 Query: 61 IA-RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + + + C + I +++K A+ + +IATS I T +T + + Sbjct: 102 CVLDGPPDVWLEVMTPCRKDFIRRTVDAVKGAKKIIVSLYIATSDNFIDTIFSTTREAQL 161 Query: 120 ERAIYMVKR----------ARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGAT----- 164 A+ + ++ T + +S E T + A A Sbjct: 162 RTAVEHARYLKTVTKDDPAHKDTTWALMWSPEAFSDTDPDFAIEICRAVKEAWEPSAEVP 221 Query: 165 -TINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGAR 223 +N+P TV + P FA + +S+H H+D G AV + AGA Sbjct: 222 IILNLPATVEMSSPNIFADQVEIFSRGFSGDPTVCVSLHNHNDRGCAVAAAELGQLAGAT 281 Query: 224 QVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 +VEG + G GER GN L + + + + + ++ ++ R ++V Q+ +P+ Sbjct: 282 RVEGCLFGNGERTGNVDLVTLALNLYTQG----IDPGLDFSDLPRIRRIVEQLTQIPVHT 337 Query: 284 NKAIVGSGAFAHSSGIHQDGVLKNRE-------------------NYEIMTPESIGLN-Q 323 G F SG HQD + K + Y M P IG + + Sbjct: 338 RAPYAGDSVFVAYSGGHQDAINKGFKRWNATANDDKHGRPRPWKVPYLAMDPHDIGASYE 397 Query: 324 IQLNLTSRSGRAAVKHRMDE-MGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIG 382 + + S+SG+ + + + + + + L A ++ KG+ + F+ Sbjct: 398 AVIRVNSQSGKGGIAWVLSQALQLEAPKAILGAFSLAVKSESELKGRTLLPNEVTNLFLR 457 Query: 383 KQQEEPEHFRLDYFSVQ----SGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINR 438 + + + R+ S S + + + +G +DAV ++ Sbjct: 458 QYNVQSQDQRVLSLVKTALNSSDSGSLVRVETVILVNGLARQLVGHGASTLDAVRFGLSA 517 Query: 439 ITEYNVELVKYSLTAKGHGK------DALGQVDIVANYNGRRFHGV 478 + +E + G ++ ++ + GR GV Sbjct: 518 FADCRLEFT-CAFGTPSAGIVNSNLPESSVIAIVMCSGGGRTTWGV 562 >UniRef50_A9VAW1 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VAW1_MONBE Length = 564 Score = 304 bits (778), Expect = 7e-81, Method: Composition-based stats. Identities = 98/402 (24%), Positives = 173/402 (43%), Gaps = 7/402 (1%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I DTTLR+GEQ + +++ IA L+ GVD +E+ P +S E + IA Sbjct: 40 IIDTTLREGEQFSSTDFTSHDRVYIAKLLDTFGVDYIELVNPFASHQAREDCRAIANLGL 99 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 +++ A RC D+ E+ + ++ATS ++ VI+ A ++ Sbjct: 100 KAKIVAHTRCHMDDVRACVET----GIDGVSMYMATSEALRRHSHGKSVQAVIDSAREVI 155 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 + ++ +V FSCED R+ +L + A G + + DTVG PF+ A ++ Sbjct: 156 EFVKDNGMEVRFSCEDTFRSDRTELLDIYAAIDELGVNRVGLADTVGIATPFQVAETVAA 215 Query: 187 LYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIM 246 + + + I HTH+D G + N+L A+ AGA + + G+GER G L + Sbjct: 216 VRSIIK--PETGIEFHTHNDTGCCIANALVALQAGATHINTCVLGVGERNGITPLGGFLA 273 Query: 247 AIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLK 306 + D +V + + + + V+ + IP N I GS AF H +G+H V+ Sbjct: 274 RMYTL-DRESVKNKYDLKLLRHLEKYVAAAAKVQIPFNNYITGSSAFTHKAGVHSKAVMS 332 Query: 307 NRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADK 366 + YE++ P+ G+ + +G A+K R ++ + + A Sbjct: 333 DPGAYEVINPDDFGVGRNIEIAHHLTGWNALKARSMDLNLTIPDDQIKAATKMVKHYAAD 392 Query: 367 KGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATA 408 KG + L IG+ + + ++ TA Sbjct: 393 KGIKPSQLDQLLIGIGRVAASNSSSDFVKMAALQPTPELKTA 434 >UniRef50_D2LHQ1 Homocitrate synthase n=1 Tax=Rhodomicrobium vannielii ATCC 17100 RepID=D2LHQ1_RHOVA Length = 427 Score = 302 bits (774), Expect = 2e-80, Method: Composition-based stats. Identities = 123/368 (33%), Positives = 179/368 (48%), Gaps = 12/368 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +S +V I DTTLRDGEQ + + EK+QIA AL +GVD +EVG P + E+++ Sbjct: 30 LSGRVAINDTTLRDGEQTPGVAFTAAEKMQIAAALADVGVDEIEVGTPAMGRDEQEAIRR 89 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 IA+ RV A R D+D A + ++ S IA K +L V+ Sbjct: 90 IAKAGLPLRVIAWCRMRRGDVDDAI----ASGVSIVNLSAPVSRFQIAAKFGGSLPRVVA 145 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 ++ AR +V F ED+ R L ++EAA AGA DT+G P Sbjct: 146 AVTDVIGYARAKGLEVAFGGEDSSRATRDTLEPILEAAARAGAVRYRFADTLGVLDPISI 205 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 I + I I H HDDLGLA N+LAA+ AGA +NG+GERAGN Sbjct: 206 RAAIEAVRR----ITDLPIEFHGHDDLGLATANTLAALEAGASAASVTVNGLGERAGNAP 261 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LE++ +A+ T I+ + S+LV++ I + IVG F H SGIH Sbjct: 262 LEQIAVALDSLF---AQATRIHLPALGHLSELVARCSGREIARSAPIVGKDVFTHESGIH 318 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 DG+LK+++ YE ++P +G N + + SG A ++H + +G + +E L A Sbjct: 319 VDGILKSKDCYEALSPRRLGRN-HRFVVGKHSGLAGLRHELSYLGLQLTEDEERRLLAAV 377 Query: 361 LKLADKKG 368 A+K Sbjct: 378 RGYAEKHK 385 >UniRef50_A8F3U8 2-isopropylmalate synthase n=1 Tax=Thermotoga lettingae TMO RepID=A8F3U8_THELT Length = 415 Score = 301 bits (770), Expect = 6e-80, Method: Composition-based stats. Identities = 118/389 (30%), Positives = 181/389 (46%), Gaps = 19/389 (4%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + +QVII D TLRDGEQ + EK+ IA L+++GV ++EVGFP S D + Sbjct: 34 LPEQVIIHDVTLRDGEQMAGVVFTEDEKVFIAQELDKIGVPMIEVGFPAVSGEDQRVFKR 93 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 +++ ++ ALAR +++D+ +AAE A + + +P + L E I+ Sbjct: 94 LSKMNLKAKKIALARIMDEDVKLAAE----CGADGLFYETSINPYFVKYVLGLDSKEFID 149 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRT-PIADLARVV-EAAINAGATTINIPDTVGYTMPF 178 R I K A+ VEF D R + + V E N I I DT G PF Sbjct: 150 RIIKGAKLAKELGLFVEFCGWDTFRINNLEWIKTVYTELLKNVEVDQIGISDTFGQAHPF 209 Query: 179 EFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGN 238 ++ + E P +S+H H+D GLA +L A+ +GA VE + N +GER GN Sbjct: 210 TVNFLVRKMKEWFP---SIPLSIHVHNDYGLATATALMAIASGAEAVETSFNCLGERTGN 266 Query: 239 CSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSG 298 S EEVI I++ + T ++ QE++R S+++ ++ M + NK IVG F SG Sbjct: 267 ASTEEVIAGIEMILG---IKTNVDCQELYRVSKMIQEVSKMHVAPNKPIVGDRIFDSESG 323 Query: 299 IHQDGVLKNRENYE------IMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYN 352 I D K E PE+ G ++ +SGRA VK +D+ G K +E Sbjct: 324 IVIDANEKINRATEIKYAMYPYNPENFGR-WLKYVGGKKSGRAFVKQYLDKRGLKANEAQ 382 Query: 353 LDNLYDAFLKLADKKGQVFDYDLEALAFI 381 +D + K+ + Sbjct: 383 IDEILVRIKKIGTVLKSALSDEDIDRIVE 411 >UniRef50_B7G5N8 2-isopropylmalate synthase n=2 Tax=Bacillariophyta RepID=B7G5N8_PHATR Length = 581 Score = 299 bits (765), Expect = 2e-79, Method: Composition-based stats. Identities = 127/563 (22%), Positives = 220/563 (39%), Gaps = 79/563 (14%) Query: 13 RDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNS---R 69 RDG Q S SV +KL+I L GVD +E G+P S+P D + ++ + Sbjct: 8 RDGTQGESVSASVDDKLKITRRLVAFGVDFVEAGWPGSNPKDAAFFTRAKTDLTHAERDK 67 Query: 70 VCALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 + A K + D ++L ++A + + LR+TLDE ++ Sbjct: 68 LVAFGSTRRKRVRANEDPQVQALLESQAPTVCIVAKAHAWQVTEILRATLDENLDMIRDT 127 Query: 126 VKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 V + V E D T + AA++ GA+ + DT G TMP+ Sbjct: 128 VACLVAHGRVVMVDLEHALDGYATDPDYVHACCRAAVDGGASVLVACDTNGGTMPWRVGT 187 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 ++ L + I +H H+D G+AV NSL A GA ++G +NGIGER GN L Sbjct: 188 VVRELVDTY-GPQGVTIGMHAHNDCGMAVANSLTAAQYGAGLIQGTVNGIGERTGNADLC 246 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 ++ ++ + +H + + S+ V ++ N VGS AFAH G+H Sbjct: 247 AIVPSLALHVQA-QLHCRASLATLTSLSRFVDEVLNQTPNHAAPFVGSSAFAHKGGLHVA 305 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKES---EYNLDNLYDA 359 + ++ +Y+ + PE +G N+ ++ ++ SGR + +M + G + + Sbjct: 306 AMERSPLSYQHIEPELVG-NEQRILISELSGRQNILGKMQQAGVDLGTSGSDRAVAILNR 364 Query: 360 FLKLADKKGQVFDYDLEALAFIGKQQEEP--EHFRLDYFSVQS----------------- 400 L + +G F+ ++ + + F++ +S Q Sbjct: 365 VKTL-EAQGYTFEGAEASVHLMILHATKGYCPPFQVLDYSAQVYDANIDSATRVLRHTES 423 Query: 401 ---------------GSNDIATAAVKLACGEEV----------------KAEAANGNGPV 429 G A A V + + + E ++GNGPV Sbjct: 424 PDTDPTDSKKPRKAPGFGPTARATVNVRTMRPIEDGLESYLANLSPYQDRLEVSDGNGPV 483 Query: 430 DAVYQAINRITE------YNVELVKYSLTAKGH--GKDALGQVDIVANYNG----RRFHG 477 DA+ A+ R + +VELV Y + A +V I N + Sbjct: 484 DALANALMRALQPVHPILQHVELVDYKVRILDAENATGATTRVMIEFRNNSDGDQETWTT 543 Query: 478 VGLATDIVESSAKAMVHVLNNIW 500 V + T+++ +S A+V Sbjct: 544 VSVDTNVISASLNALVDGFEYAL 566 >UniRef50_D0LNR8 Pyruvate carboxyltransferase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNR8_HALO1 Length = 429 Score = 296 bits (759), Expect = 1e-78, Method: Composition-based stats. Identities = 107/368 (29%), Positives = 169/368 (45%), Gaps = 11/368 (2%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + + V I D TLRDGEQA L+V+EKL +A L + GVDV++ GFP SSP D E++Q Sbjct: 10 LIKPVEIIDCTLRDGEQAPGVWLTVQEKLALAKLLSQAGVDVLDAGFPASSPADMEAMQE 69 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 + +R+ A AR + +DI A ++A A + F+ TS + + L T D+ I Sbjct: 70 MVAAGLRARIAATARPLARDIVAA----EMANAHEVFMFLPTSALRMEQTLGITRDQAIS 125 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAA-INAGATTINIPDTVGYTMPFE 179 + + + EDA R+ L +V A + + DTVG +P Sbjct: 126 LFCSGAEEVCSRGMTLNLVFEDATRSRPEMLTEIVRQVHAQADVRRVILADTVGCAIPAA 185 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 + + + +++ H H+D GLAV N+LAAV GA V +NGIGERAGN Sbjct: 186 MEALTRTVRSEIDA--DIVVTPHCHNDFGLAVANTLAAVSGGAGAVTCTVNGIGERAGNA 243 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 L E + + + ++ ++ + V + K + G F H SGI Sbjct: 244 DLAETVAGLSLLLQR---EHGVDPHQLVALQEAVEIATGIHQSPTKPVTGINVFRHESGI 300 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 H DG+LK+ +YE + +G + + L SG + ++ G E+ L Sbjct: 301 HVDGMLKDPRSYEFLPASWVGR-RSEYILGKHSGTSLIRRLAHMAGLDCDEHTASLLLAE 359 Query: 360 FLKLADKK 367 ++ Sbjct: 360 VKAATQQR 367 >UniRef50_Q01181 Homocitrate synthase n=27 Tax=Proteobacteria RepID=NIFV_RHOSH Length = 391 Score = 296 bits (758), Expect = 1e-78, Method: Composition-based stats. Identities = 109/375 (29%), Positives = 164/375 (43%), Gaps = 15/375 (4%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V + DTTLRDGEQ + + EK IA AL+ GV +EVG P + ++ +A Sbjct: 19 VALCDTTLRDGEQTAGVAFTRAEKRAIAEALQAAGVAEVEVGVPAMGEEERADIRAVAAV 78 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 +K + R +D + + R+H + S I+ KL V ++ Sbjct: 79 LKTAAPVVWCRLRAED----LAAAQRTGVVRLHIGVPVSERQISAKLGKDAAWVRDKVEK 134 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 +V+ A V EDA R LA + A AGA I DT+G PF ++ Sbjct: 135 LVRAASWAGHKVSVGAEDASRADPFFLAEIAHVAAEAGAIRFRISDTLGVLDPFAAHELV 194 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + R P + H H+DLG+A NSLAA AGA + +NG+GERAGN + Sbjct: 195 GRVVTRCP----LPVEFHGHNDLGMATANSLAAARAGASHLSVTVNGLGERAGNAA---- 246 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 + + + T + ++ S+LV++ P+ K IVG G F H GIH DG+ Sbjct: 247 LEEVAAALEAAGRATGVALGQLCALSELVARASGRPLSPQKPIVGEGVFTHECGIHVDGL 306 Query: 305 LKNRENYE--IMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 +K+R YE + PE G + ++ + S A + + E G L L A Sbjct: 307 MKDRATYESADLRPERFGRS-HRIAIGKHSSAAGLARALAEAGLPADAATLAALMPALRD 365 Query: 363 LADKKGQVFDYDLEA 377 A + + A Sbjct: 366 WAAITKRAAAPEDLA 380 >UniRef50_Q07179 Homocitrate synthase n=3 Tax=Rhodobacter RepID=NIFV_RHOCA Length = 382 Score = 294 bits (753), Expect = 5e-78, Method: Composition-based stats. Identities = 112/390 (28%), Positives = 175/390 (44%), Gaps = 16/390 (4%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + + + DTTLRDGEQ + S+ EK IA AL+R GV +EVG + ++ + Sbjct: 5 RTLALCDTTLRDGEQTAGVAFSLAEKKAIARALDRAGVAEIEVGIAAMGWAEVAEIRAVV 64 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 ++ ++ R D+D+A ++ R+H + TS + KLR D ++ Sbjct: 65 AEIAHATPVVWCRLRMHDLDMAQKT----GVKRVHFAVPTSTAQLEGKLRVDRDWILRET 120 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 +V A + V EDA RT L R+ E A AGA I DT+G P Sbjct: 121 AALVFCASDRGLQVSVGAEDASRTDPDFLIRLAEVAAAAGAIRFRIADTLGLLDPLGAFR 180 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 +++ L R+ I +H H+D G+A N++ A HAGA + +NG+GERAGN + E Sbjct: 181 LVAELSARI----SLPIEMHAHNDFGMATANTIMAAHAGATHLSVTVNGLGERAGNAACE 236 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSG-AFAHSSGIHQ 301 EV A++ + T ++ + S +V++ A K I G FAH SGIH Sbjct: 237 EVGAALEAGG----IDTGLDLCALPELSAVVAKASGRAFRAQKPITGDDWLFAHESGIHV 292 Query: 302 DGVLKNRENYEI--MTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 D +LK + YE P G + Q+ + SG A ++ + E G + LD L Sbjct: 293 DAILKRADTYEDPRCAPARFGRER-QIVIGKHSGSAGLRAALLEAGLPADDAVLDRLKPL 351 Query: 360 FLKLADKKGQVFDYDLEALAFIGKQQEEPE 389 A + + + + P Sbjct: 352 LRAHAVRVKRPVEAGDLRRMVARLARPSPR 381 >UniRef50_Q04QM8 Isopropylmalate/homocitrate/citramalatesynthase n=15 Tax=Leptospira RepID=Q04QM8_LEPBJ Length = 435 Score = 293 bits (750), Expect = 1e-77, Method: Composition-based stats. Identities = 117/381 (30%), Positives = 195/381 (51%), Gaps = 18/381 (4%) Query: 1 MSQQV-IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQ 59 + + D TLRDG QAL+ + +K I L ++GV +EVGF S+ +F++ Sbjct: 36 LPKHPPFFMDVTLRDGNQALRKPWDLDQKETIFKQLIKLGVQGIEVGFASSNSQEFKTCS 95 Query: 60 TIARQVK-NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEV 118 ++ N + +L+R VEK+I ++ ++++ A RIH S I L+ + ++V Sbjct: 96 RLSSIAPDNVVISSLSRAVEKEIKISWKAIRHASKPRIHIVYPISAFTIQNVLKLSPEKV 155 Query: 119 IERAIYMVKRARNYTD---DVEFSCEDAGRT--PIADLARVVEAAINAGATTINIPDTVG 173 +E+ V A++ +++FS E G + + A+N GA IN+P+TV Sbjct: 156 LEKISESVSFAKSLVGSKGEIQFSGEHFGDSLENLDFAVEAFRTALNYGADIINLPNTVE 215 Query: 174 YTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIG 233 P+ F ++ + +P A ISVHTH+DLG+A ++ + +GA Q+E A+NG+G Sbjct: 216 RYRPWLFVSMVKAVRNVLPE--NAKISVHTHNDLGMATATTVESYFSGAVQLETALNGLG 273 Query: 234 ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAF 293 ERAGN + EV +A+ V +N I+ TS+LVS + N+PI +VG Sbjct: 274 ERAGNTNTYEVAIALHN----CGVDVPLNLSAIYETSRLVSYLSNVPIYEKAPLVGEDVI 329 Query: 294 AHSSGIHQDGVLKNRE----NYEIMTPESIGL-NQIQLNLTSRSGRAAVKHRMDEMGYKE 348 +H SGI+QDGV K R Y IG + ++ TS+SGR+A+ + + G Sbjct: 330 SHRSGIYQDGVAKTRHLSKGAYRAFNATLIGRPEEDRIEFTSQSGRSAIFCILKDAGEDI 389 Query: 349 SEYNLDNLYDAFLKLADKKGQ 369 + L K+++ G+ Sbjct: 390 TLEQAGKLQPILKKISEDSGK 410 >UniRef50_C9K7B8 Similar to 2-isopropylmalate synthase n=1 Tax=Alternaria alternata RepID=C9K7B8_ALTAL Length = 582 Score = 293 bits (749), Expect = 1e-77, Method: Composition-based stats. Identities = 116/540 (21%), Positives = 214/540 (39%), Gaps = 71/540 (13%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + ++F T LRDG Q+L ++ ++KL + L +G +EV +P ++ +F+ V+ Sbjct: 57 LKTAPVLFSTDLRDGNQSLPNPMTFEQKLSLYKLLVSIGFKEIEVAYPCANQAEFDFVRH 116 Query: 61 IARQV----KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 + ++ + + C E+ I A ES++ A+ + T++ +S + T L+ + D Sbjct: 117 LIETPGLIPEDVLIQVITPCQEETIKRAVESVRGAKQAILFTYLPSSDNYRDTVLKISED 176 Query: 117 EVIERAIYMVKRARNYT------------DDVEFSCEDAGRTPIADLARVVEAAINAGAT 164 + +ERA + AR+ T F ED I + R EA Sbjct: 177 DWVERARWGAAYARSITKDSEDPVVRSTRWTFNFGFEDFANARIGAIIRCTEAVRAEWNP 236 Query: 165 ------TINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAV 218 I + +V + P FA I L + N D ++VHTH+D G AV ++ A Sbjct: 237 SKDEKMIIGVASSVEASTPNVFADQIECLSGNISNRDTVRLTVHTHNDRGGAVASAELAS 296 Query: 219 HAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICN 278 AGA ++EG + G GERAGN L V+ A+ + + I+ + ++ I Sbjct: 297 LAGADRIEGCLFGNGERAGNMDL--VVYALNLLTQG--IEPGIDLSRLDEIRKVYEDITE 352 Query: 279 MPIPANKAIVGSGAFAHSSGIHQDGVLKN--------------------RENYEIMTPES 318 +P+ G+ SG HQD + K R Y + P Sbjct: 353 LPVHPRTPYSGAYYLKAFSGAHQDAISKGLRLRTSATQEGKPCAVWPAWRVPYLPLDPAD 412 Query: 319 IGLNQIQLN-LTSRSGRAAVKHRMD-EMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLE 376 IG + + + S+SG+ V ++ +G A + + G+ D Sbjct: 413 IGRSLDDVVGINSQSGKGGVAWVVNLGLGLDLPPGLARTFSKAVKERSIHFGREMSSDEV 472 Query: 377 ALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAI 436 +AF+ + Q + D +Q+ L + A G + ++ +I Sbjct: 473 CMAFLEEYQVLRAADKSDDDMIQA----------VLRTESPLVAALGQVVG-LSSLSASI 521 Query: 437 NRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVL 496 T + +++ Y+ ++ + GVGL + ++ +A+V L Sbjct: 522 TSHTLAD-DVLSYA-----------AYANVTPEESKPSLWGVGLGVSLQQAKLRAVVSAL 569 >UniRef50_B8FRV4 2-isopropylmalate synthase n=2 Tax=Desulfitobacterium hafniense RepID=B8FRV4_DESHD Length = 404 Score = 291 bits (745), Expect = 4e-77, Method: Composition-based stats. Identities = 88/382 (23%), Positives = 168/382 (43%), Gaps = 14/382 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + Q++ I D TLRDGEQ S ++K++IA L +GV+ +E G P S D ++++ Sbjct: 27 LPQKIEIHDATLRDGEQTPGVVFSKEDKVRIAELLAEVGVERIEAGMPAVSKDDAQAIEE 86 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKL--RSTLDEV 118 IA++ ++ R + +D+D A + A I + + + + T + + Sbjct: 87 IAKRNLGPKIMVFCRAMREDVDRAVD----CGADGIVLEAPSGYPKLKYQFASKWTEESL 142 Query: 119 IERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAA-INAGATTINIPDTVGYTMP 177 E + + A+ V + D R + L R++ A ++ + DT G P Sbjct: 143 TEAVVNTINYAKEKGLFVNYFPFDTTRAELPFLKRLLTNVTTQAKPDSVTVVDTTGSITP 202 Query: 178 FEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 ++ + E + + VHTH+D GL + AAV G + V +NG+GER G Sbjct: 203 TAMRFLVRQVRETIA----LPLEVHTHNDFGLGTATTFAAVEEGVQVVHSCINGLGERTG 258 Query: 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 N +LEE+ + +K+ I N Q++ SQ V ++ + NK +VG F Sbjct: 259 NTALEEIALGLKLLYGIE--LPKFNFQKLSELSQEVQRMSGKTLAQNKPVVGLLPFTREI 316 Query: 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 G+ + P+ +G ++++ + +SG+ +V +++ G K +E + + Sbjct: 317 GLGMKVLEDYPTAVFPFMPDFVG-QKMKIVMGKKSGKESVLMKLEAAGLKANEEQVQEIV 375 Query: 358 DAFLKLADKKGQVFDYDLEALA 379 K + + + Sbjct: 376 ARTKAAGIAKRNWLEDEEFLVI 397 >UniRef50_A3JSY7 Putative uncharacterized protein n=2 Tax=Bacteria RepID=A3JSY7_9RHOB Length = 403 Score = 289 bits (740), Expect = 1e-76, Method: Composition-based stats. Identities = 101/381 (26%), Positives = 179/381 (46%), Gaps = 14/381 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + +V I D TLRDGEQ S+ +K+ IA L+ +GVD +E G P SP D ++ Sbjct: 28 LPAKVEIHDATLRDGEQTPGVVFSIDDKIAIASKLDELGVDRIEAGMPAVSPQDATAITE 87 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I++ S++ AR ++ DID+A + A + + + T+ T ++V++ Sbjct: 88 ISKLGLKSKIYTFARAMKADIDMALQ----CGADGVIIEVPIGYPKLKTQFGWTWEDVVK 143 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAIN-AGATTINIPDTVGYTMPFE 179 ++ ++ A+ F D R +DL + +A ++ + I + DT+G P Sbjct: 144 KSAPVINYAKENGLHAVFFPYDTTRARRSDLENMCKAIMDQSPPDAIGLVDTMGCATPEA 203 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 ++ L + + + +HTH+D G+ V LAAV AGA+ V NG+GER GN Sbjct: 204 IKYMVRWL----TKMTELPVEIHTHNDFGMGVATELAAVTAGAQCVHSCANGLGERTGNA 259 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 +LEE++M + + T +I L+++ N+ I NK ++G G F SGI Sbjct: 260 ALEELMMGLHLLYG---YDTQYKLGKIPELGALIAERSNISIARNKPVLGHGNFIRESGI 316 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGY-KESEYNLDNLYD 358 D V+ + T S+ ++ L +SG+A++ ++M E+G + + + + Sbjct: 317 GIDYVMNDP-LVMFGTHPSLTGKVGEVVLGKKSGKASIIYKMGELGMGVLEDDKIAMILE 375 Query: 359 AFLKLADKKGQVFDYDLEALA 379 K V + A Sbjct: 376 EVKNAGIAKRDVLSHGEFANI 396 >UniRef50_C7N750 Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Slackia heliotrinireducens DSM 20476 RepID=C7N750_SLAHD Length = 471 Score = 289 bits (739), Expect = 2e-76, Method: Composition-based stats. Identities = 140/502 (27%), Positives = 240/502 (47%), Gaps = 33/502 (6%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + V + D T+R E + +L+ KEKL+ A L+ +GV +E+ S D +++IA Sbjct: 2 RDVRVSDVTMRQAEVSGSLALTFKEKLETAKLLDSLGVSSIEIEGVERSKADALRIKSIA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERA 122 VKNS + + +++I V +LK A R+ A SP + D +++ Sbjct: 62 SIVKNSVLAVPVKMDDENIQVVWGALKNAAFPRLQVVAAVSPARMEYVYHKKADGMMKDV 121 Query: 123 IYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAG 182 + + TDDVEF +DA R L V++ AI AGA TI + D G +P EFA Sbjct: 122 AATIAKCAALTDDVEFVADDATRADSVYLRSVIKEAIQAGAKTITVCDDAGTMLPEEFAQ 181 Query: 183 IISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 I L + +P + + + +DL +A ++A + +G +++ + SLE Sbjct: 182 FIDDLRKDLPELADVALGISCSNDLFMADACAIAGIMSGVDEIKATTYPM----NVISLE 237 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 +V + + +I T + E+ RT+ V++IC Sbjct: 238 KVCKVLAAKPEICQAQTTVRVTELKRTAAQVARIC------------------------- 272 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 + R Y P G ++ LT AV + ++GY+ SE + N+Y+AFL+ Sbjct: 273 --EQGRSKYSAFNPNVTGSDES-FVLTVNDDIDAVMECVAKLGYELSEEDATNVYEAFLR 329 Query: 363 LADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEA 422 +A KK V + +L+A+ + P + L+ + + SG+ ATA V++ G+EV Sbjct: 330 IASKKDSVSNLELDAIVASAAL-QVPATYVLENYVINSGNAIKATANVRMRKGDEVLEAV 388 Query: 423 ANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLAT 482 G+GP+DA + AI +I+ EL + + + G++A+GQ + +G+ + G G++T Sbjct: 389 CIGDGPIDASFLAIEKISGKRYELDDWQMQSVTEGQEAMGQAIVKLVADGKIYSGRGIST 448 Query: 483 DIVESSAKAMVHVLNNIWRAAE 504 DIV SS +A V+ LN I E Sbjct: 449 DIVGSSIRAYVNALNKIVYEEE 470 >UniRef50_Q0W3Q1 2-isopropylmalate synthase n=8 Tax=Archaea RepID=Q0W3Q1_UNCMA Length = 468 Score = 284 bits (728), Expect = 4e-75, Method: Composition-based stats. Identities = 108/406 (26%), Positives = 178/406 (43%), Gaps = 31/406 (7%) Query: 1 MSQ-------QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPG 53 M + ++ I DTT+RDG Q + KLQI L MGV+ +E V + Sbjct: 8 MPKIRLPHSAEIKISDTTIRDGCQMPGVVMKKSHKLQIFEYLHEMGVEKLET--FVYNDR 65 Query: 54 DFESVQTIARQV-KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLR 112 D ++ +++ + V AR DID E LKV ++ S HI K+ Sbjct: 66 DKDACKSMMDYGYEFPEVTGWARANPADID---EVLKVDGIRETGILMSVSDSHIFDKMG 122 Query: 113 -STLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTI-NIPD 170 + E ++ + ++ A ++ ED R + V+ I TI I D Sbjct: 123 LKSYAEAEQKYLKALQYAIDHGLKTRCHIEDTSRANYEFVYPFVQKLIEIDPDTIIRICD 182 Query: 171 TVGYTMPFEFAGI---ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEG 227 T+GY +PF I + + + + I +H HDD GL +GN+LA + GA Sbjct: 183 TLGYGIPFPGYEEPYGIPTVVKNLKEMGVKHIEMHVHDDFGLGIGNTLAGLWYGADWASL 242 Query: 228 AMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAI 287 GIGERAGN LE+++ + R + N Q+ ++ + Q + +P NKAI Sbjct: 243 TFLGIGERAGNTELEKIMAFLITRVEGFE---KYNLQKATEFAEYMEQEIGLRVPRNKAI 299 Query: 288 VGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDE---- 343 VG F+H SGIH G++KN YE PE +G + L + SG ++ +++E Sbjct: 300 VGKNIFSHESGIHTAGIIKNPFTYEPFPPELVGGKRN-LMIGDTSGTDVIRLKVEEALSE 358 Query: 344 -MGY----KESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQ 384 +G + + + ++ K+ D + + E L ++ Sbjct: 359 LLGIKAQVNKHDPRIKCIHKDIQKMYDAEDRRSSVSDEELHDFVRK 404 >UniRef50_C6BX35 Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio salexigens DSM 2638 RepID=C6BX35_DESAD Length = 368 Score = 282 bits (721), Expect = 2e-74, Method: Composition-based stats. Identities = 105/372 (28%), Positives = 181/372 (48%), Gaps = 17/372 (4%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR-Q 64 ++ DTTLR+G Q A +++ + +IA +L MGVD +E+G+ D AR Sbjct: 1 MLIDTTLREGAQLFGAYFNLETRKRIASSLISMGVDEIEMGW--VGQDDLALFAGYARTL 58 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 ++ + + C EKDI+VAAE RI+ + S +HI +L S ++ + Sbjct: 59 GGDTALSVWSPCREKDIEVAAE----LGLKRINIGVPVSDLHIEKRLDSDRQAILRKLAA 114 Query: 125 MVKRARNYTDD-VEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 V+ A++ + V ED R + A GA+ + + D++G P + Sbjct: 115 AVRTAKDCGFEYVSVGLEDISRADGDFALSMALHAEICGASRVRLADSLGQLTPLAMEKL 174 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 + E++ I+VH HDD G+A NS A+ AGA + ++ GIGER+G + EE Sbjct: 175 VRKFREKLH----IDIAVHCHDDFGMATANSFTALEAGADYADCSVIGIGERSGIAATEE 230 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 ++ + +R+ T + + +V + IP KA+VG+ FA SG+H Sbjct: 231 LVARLALREGNTRYSTTV----LKDACMVVGAAAKVAIPRTKAVVGTDIFACESGLHTHA 286 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKL 363 + K+ E +E P+S+G + +L + +SGRAAV++ +DE G +L L +A +L Sbjct: 287 LSKSPELFEPYDPDSVGTVR-KLAVGGKSGRAAVRNALDEYGIDCGTDSLSTLTEAVRQL 345 Query: 364 ADKKGQVFDYDL 375 + + + Sbjct: 346 SLRLERPLTRSE 357 >UniRef50_D1U2X4 Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio aespoeensis Aspo-2 RepID=D1U2X4_9DELT Length = 377 Score = 282 bits (721), Expect = 3e-74, Method: Composition-based stats. Identities = 94/386 (24%), Positives = 168/386 (43%), Gaps = 12/386 (3%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 ++ DTTLR+G Q A ++ + I L +GV+ +E+G+ V G V+T+ ++ Sbjct: 1 MLIDTTLREGAQLFGAYFTLDTREAIIAGLLDLGVEEIELGW-VGQEGLETLVRTMRKRA 59 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 +R+ + C E D+ AA ++ + S H+ +L V+ER Sbjct: 60 GATRLSVWSPCREADVRAAA----GLPVDCVNIGVPVSDAHMEKRLGMDRQAVLERITST 115 Query: 126 VKRARNY-TDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 V AR V ED R+ + A AGA+ + + D++G P +I Sbjct: 116 VLAARLMDVSAVSVGLEDVSRSDLGFALTAALTAAEAGASRVRLSDSLGILTPVRMQALI 175 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + ++VH HDD G+A N++ A+ AGA + ++ GIGER+G + EE+ Sbjct: 176 DLFRPAL----DIDLAVHCHDDFGMATANAVTALDAGADYADASVLGIGERSGIAATEEL 231 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 + + + + + VS+ +PIP K+I G FA SG+H + Sbjct: 232 AAHLCLNGNNSPCRP-YRTDGLRALCRFVSKAAGVPIPRTKSIAGDDIFACESGLHAHAL 290 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 K+ + +E P IG + ++ + +SGR AV + + + + + NL + + A Sbjct: 291 SKSPDLFEPYDPARIGAGR-RIAVGGKSGRGAVVNALADFNLHCPDTAIPNLVNTVRQRA 349 Query: 365 DKKGQVFDYDLEALAFIGKQQEEPEH 390 + + A G + E Sbjct: 350 WELRRPLTRTEFARLTEGCRDSEKNR 375 >UniRef50_B5HTY3 2-isopropylmalate synthase n=1 Tax=Streptomyces sviceus ATCC 29083 RepID=B5HTY3_9ACTO Length = 593 Score = 279 bits (713), Expect = 2e-73, Method: Composition-based stats. Identities = 114/534 (21%), Positives = 193/534 (36%), Gaps = 68/534 (12%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 + + LRDG QAL + ++ K ++ L R+G +E+G+P +S +FE V+ + Sbjct: 69 AHAPLWSSVDLRDGNQALANPMDLRRKRKMFDLLVRLGFKDIEIGYPSASETEFEFVRHL 128 Query: 62 A---RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEV 118 + V + + ID E+++ + +H AT+ + R T EV Sbjct: 129 ITGGHIPDDVTVTVFTPAIPELIDRTFEAVRGTDRAVVHLCHATACLWREVVFRKTPSEV 188 Query: 119 IERAIYMVKRARNYTDD------VEFSCEDAGRTPIADLARVVEAAINA------GATTI 166 + A +R D E+S E T + T+ Sbjct: 189 MALAQESAQRLVRLADRADGAIRFEYSPETFNVTEPQFALEIANTVAEIVEATPERPLTL 248 Query: 167 NIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVE 226 N+P TV P FA I + + D I+SVH H+D G AV + A+ AGA +VE Sbjct: 249 NLPSTVEMHAPTVFADQIEWMSRNLDRRDGIILSVHPHNDRGTAVAAAEFALAAGADRVE 308 Query: 227 GAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKA 286 G + G GER GN L + + + R V ++ +I + + MP+P Sbjct: 309 GTLFGNGERTGNVCLITLALNLFSRG----VDPQLDLSDIPSVRRAAEECNRMPVPDRHP 364 Query: 287 IVGSGAFAHSSGIHQDGVLKNRE--------------------NYEIMTPESIGLN-QIQ 325 G F SG HQD + K Y + P+ +G + + Sbjct: 365 YAGDLVFTAFSGTHQDAIAKGLLHLEDQAAAAGVPAAELPWDVPYLPVDPQDLGRSYEAV 424 Query: 326 LNLTSRSGRAAVKHRMDEM-GYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQ 384 + + S+SG+ + H + G + ++ D G D Sbjct: 425 IRVNSQSGKGGIAHVLRTRWGIELPVALRAEFARVVQRVTDLSGTEVDPGRIW------- 477 Query: 385 QEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNV 444 + FR +Y + A A+ + A A G VDA + + R Sbjct: 478 ----DVFRAEYCDAGDWAGFTAPASGDDPAEALLAAARAYG---VDAHVEQLVRDEG--- 527 Query: 445 ELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNN 498 G G + + + G GL E++ +A++ L+ Sbjct: 528 --------GPGSGARHVCYAQLFVAHE--PVWGAGLGATAGEATVRAVLSALHR 571 >UniRef50_Q1IYY1 Homocitrate synthase n=1 Tax=Deinococcus geothermalis DSM 11300 RepID=Q1IYY1_DEIGD Length = 389 Score = 278 bits (712), Expect = 3e-73, Method: Composition-based stats. Identities = 88/363 (24%), Positives = 164/363 (45%), Gaps = 9/363 (2%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I D+TLR+GEQ + + +K++IA L+ G + +EV P+ ++ + Sbjct: 17 IIDSTLREGEQFARGNFKTGDKIEIARLLDAFGAEFLEVTTPMVGAQTQADIRRLTSLGL 76 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 N+++ RC +D+ A + + TS ++ ++I+ A ++ Sbjct: 77 NAKILTHVRCHLEDVQRAVD----LGVDGLDLLFGTSSFLREFSHGKSIAQIIDTASEVI 132 Query: 127 KRARNYTDD--VEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 + D + FS ED R+ ADL V A + G + + DTVG P + ++ Sbjct: 133 GWIKQNHPDLEIRFSAEDTFRSEEADLMAVYRAVSDLGVHRVGLADTVGVATPRQVYTLV 192 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + + + + I H H+D G AV N+ A+ AGA ++ + GIGER G L Sbjct: 193 REVRKVIHA--ECGIEFHGHNDTGCAVSNAYEAIEAGATHIDTTILGIGERNGITPLGGF 250 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 + + D + N + + +L++++ ++PIP N + G A+ H +G+H + Sbjct: 251 LARM-FTFDPQGLIDKYNLELLPELDRLIARLVDLPIPWNNYLTGEFAYNHKAGMHLKAI 309 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 N YE + P G+ + + +G+ A+ H+ E+G E L + D LA Sbjct: 310 YLNPGAYEAIPPSVFGVGRRIQAASKVTGKHAIAHKARELGLHYGEDALRRVTDHIKALA 369 Query: 365 DKK 367 ++ Sbjct: 370 EEG 372 >UniRef50_B0PEC7 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PEC7_9FIRM Length = 403 Score = 276 bits (707), Expect = 1e-72, Method: Composition-based stats. Identities = 95/382 (24%), Positives = 161/382 (42%), Gaps = 18/382 (4%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + I D TLRDGEQ L+ +K+ +A + +G+ +E G P S D +V I ++ Sbjct: 30 IKIHDVTLRDGEQQAGLVLTCDQKIALAEKMAELGIHRIEAGMPAVSAEDARAVSEIVKR 89 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 + + ARC+ D+ AA+ I I ++ I +L++ +E ++ Sbjct: 90 RLPTEIFGFARCMVDDVKRAAD----CGVSGIVIEIPSNEEMIREAYGWSLEKAVELSVK 145 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVV-EAAINAGATTINIPDTVGYTMPFEFAGI 183 K A+ F D R I + +++ + A + + + DT+G P + Sbjct: 146 ATKAAQGAGLYTVFFPIDMTRANIDWVLKLIGQVAADGHMDALAVVDTMGGLAPHTVPYL 205 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 I + R+ + VH HDD GL V NS+ + AGA V ++ GERAGN + E Sbjct: 206 IDAIKSRI----DKPLEVHFHDDFGLGVANSIMGLAAGADVVHTTISACGERAGNAAYEH 261 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 + +A+ +++ +I+ S+L+ ++P+ N ++G F SGI G Sbjct: 262 LALALLTMYG---YDLGLDYSKIYSLSKLLRSFIDLPVRGNMGVIGDRVFDIESGI-VAG 317 Query: 304 VLK-----NRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYD 358 K N PE G ++ L SG ++ D + K + +L Sbjct: 318 WYKNVKNTNPLLVTPYLPELTGHPGTEVVLGKHSGGPSIDCWADRLHIKLDKEQKSDLLG 377 Query: 359 AFLKLADKKGQVFDYDLEALAF 380 A KKG D L F Sbjct: 378 QIKLAACKKGNTLDEQEVRLLF 399 >UniRef50_C0AC93 Trans-homoaconitate synthase n=2 Tax=Opitutaceae bacterium TAV2 RepID=C0AC93_9BACT Length = 397 Score = 276 bits (706), Expect = 2e-72, Method: Composition-based stats. Identities = 120/372 (32%), Positives = 177/372 (47%), Gaps = 12/372 (3%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 ++ + DTTLRDGEQA S +KL IA AL V +EVG P + G + + + Sbjct: 6 PHRLHLIDTTLRDGEQAAGVVFSQADKLAIARALVEARVPELEVGIPAAGAGAIDDINAV 65 Query: 62 ARQV-KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 A V +R+ R + DI +A + +H S +H+ +T V+ Sbjct: 66 ADAVAGRARIITWCRALPGDIALA----RACRVTGVHLSFPVSNIHMRI-WGATPATVLA 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 + AR + D V +DA R LA AA A + + DTVG+ P + Sbjct: 121 SLDELTAAAREHFDQVTVGAQDASRADPGFLAEFAAAAARTPAVRLRLADTVGFLTPDKT 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 AG+ S L P + + +H H+DLGLA N+LAA AGA +NG+GERAGN + Sbjct: 181 AGLTSHLRHAAPAL---PVEIHAHNDLGLATANTLAAFSAGASAASLTVNGLGERAGNAA 237 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH 300 LEEV+MA+KV + + I+ S LV++ P+P K +VG+GAF H SGIH Sbjct: 238 LEEVVMALKVAQG---IDCGIDTSRFVELSALVARASRRPVPVQKPVVGAGAFLHESGIH 294 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 G+L++R +YE P +G L + +G AAV + G ++ +L + Sbjct: 295 CAGLLRDRRSYEPFDPADVGHAASDFVLGAHTGGAAVAAALATCGVTLAKTEARHLAEEV 354 Query: 361 LKLADKKGQVFD 372 A G Sbjct: 355 RSRAQASGVPLT 366 >UniRef50_C7LNR6 Pyruvate carboxyltransferase n=1 Tax=Desulfomicrobium baculatum DSM 4028 RepID=C7LNR6_DESBD Length = 373 Score = 274 bits (701), Expect = 6e-72, Method: Composition-based stats. Identities = 97/368 (26%), Positives = 171/368 (46%), Gaps = 15/368 (4%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 ++ DTTLR+G Q S+ + K++IA + MGV+ +E+G+ G E V+ + + Sbjct: 1 MLIDTTLREGAQMFGTSIPQEAKIRIAGRIADMGVEEIEIGWMGQ-EGLDEVVKALRGRG 59 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 + + C D+ AA I+ + S +HIA +LR+ D + Sbjct: 60 VTCDLSVWSPCRTVDVYRAA----GLSIDTINIGLPVSDLHIAERLRTDRDGLTRMLRET 115 Query: 126 VKRARNYT-DDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 V A + + ED R + A GA I + DT+G P A ++ Sbjct: 116 VGLAHSCGIRRISIGLEDVTRADQDFALSMARMAKELGAARIRLADTLGVMTPTRIAELV 175 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + V I++H H+D G+A N++ A+ AGA + ++ GIGER+G +LEEV Sbjct: 176 RFFAQSV----DMEIAIHCHNDFGMATANAITALEAGAHWADVSVLGIGERSGISALEEV 231 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 +++ + + + LV++ +P+ N+ + G FA SG+H DG+ Sbjct: 232 AGHLRLVQGYDI----YDMNLVRALCDLVAEYARIPVARNRPMSGGDIFAAESGLHVDGI 287 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLA 364 LKN +E P G + L L +++GR AV+ + ++G K +++ N+ D + A Sbjct: 288 LKNPALFEPYDPAQTGAKR-ILALGAKAGRGAVRTMLRQVGLKGPLHSIGNMVDTIRERA 346 Query: 365 DKKGQVFD 372 + G+ Sbjct: 347 HRTGRPLT 354 >UniRef50_Q2FZS6 2-isopropylmalate synthase, putative n=51 Tax=Staphylococcus aureus RepID=Q2FZS6_STAA8 Length = 381 Score = 271 bits (694), Expect = 4e-71, Method: Composition-based stats. Identities = 103/391 (26%), Positives = 175/391 (44%), Gaps = 14/391 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + I D T+RDG Q S+ K ++ + ++ ++ +EVG + +F Q Sbjct: 2 IRIQDNTIRDGMQQSNVRKSLIIKKEVLKQINKLNINSVEVGMCTTIEDEFNIHQFRDIL 61 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 + L R EK+I + + + S +HI KL + I++ Sbjct: 62 SPEKELVVLTRLNEKEIKKIVK--LKIHNLVVKILLPISDLHIKEKLNFSNKYYIQKIKD 119 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 + + V+ ED RT L +E T+ DTVG + P E+ I Sbjct: 120 CLDILKKDKKGVDICFEDGTRTSREKLKEYMEIISKYQVRTVTFADTVGCSTPLEYGDIF 179 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + ++ N I S H H+DLGLA N+LAA+ GA+Q+E GIGERAGN +EE+ Sbjct: 180 NYFVKKYSN---IIFSAHCHNDLGLATANTLAAILNGAKQIETTFLGIGERAGNAPIEEI 236 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 I + ++ T ++++TS +S+I + I NK I+G F H SGIHQDG Sbjct: 237 ITILTKKQ---IESTEFTLPDVYKTSINISKILDFQISENKPIIGENIFKHESGIHQDGT 293 Query: 305 LKNRENYEIMTPESIGLNQIQLN---LTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 KN Y+ + P +GL Q+ +++ S + + ++ + + +D + Sbjct: 294 KKNINMYQYLVPSDLGLKNSQVVQFPISNISSKKILHNKFKSI---VNTEEIDENISFYK 350 Query: 362 KLADKKGQVFDYDLEALAFIGKQQEEPEHFR 392 + +V D L I K++ + +F+ Sbjct: 351 LVNKFSPEVAPEDTVDLLQIIKRRSKDGNFK 381 >UniRef50_B9YLN5 2-isopropylmalate synthase n=2 Tax=Nostocaceae RepID=B9YLN5_ANAAZ Length = 394 Score = 269 bits (689), Expect = 1e-70, Method: Composition-based stats. Identities = 106/388 (27%), Positives = 186/388 (47%), Gaps = 15/388 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + I D+TLR+GEQ S K KL IA L+R+G+D++EVG P ++ IA Sbjct: 2 IQILDSTLREGEQTPGVYFSPKTKLVIAQFLDRIGIDIIEVGNPAVDTEIALAINQIANA 61 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 +++ A + C + A + + + F + SP + L+ I++ + Sbjct: 62 GLKAKIGAHSLCKIDSVQKALD----CDVDFLGIFFSVSPQRLYRDYNICLERAIDKIVE 117 Query: 125 MVKRARNYTDD--VEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE--- 179 ++ AR D + ++ ED R+PI ++ +AA+ AGA I+I DT GYT PF Sbjct: 118 VISYARTQKSDLLIRYTPEDTVRSPIENVIAAAKAAVQAGANIISIADTTGYTNPFHPQR 177 Query: 180 -FAGIISGLYERVPNIDKAI-ISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 + + E + I VH H+D GLA+ N L A AGA ++ A+ G+GERAG Sbjct: 178 SIYFYVKTVKEELGKEGLYPQIEVHCHNDKGLALANVLDAYRAGADIIDVAVMGLGERAG 237 Query: 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 L E+++ + + N + VS+ ++ IP ++A+ G AF H + Sbjct: 238 IVDLAELLINLIDMDEEGNFWQ---LNYLKDLYDFVSEQSHISIPPHQAVTGKYAFTHYA 294 Query: 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 G+H V K+ Y+ + P+ +G+ + L +SG AAV+ + ++G ++ N D + Sbjct: 295 GVHVKAVAKDERLYQSLNPQILGIK-SSVALGMQSGCAAVELAIKQIGREDLARNKDLIT 353 Query: 358 DAFLKLADKKGQVFDYDLEALAFIGKQQ 385 ++ + + D+E ++ Sbjct: 354 KILKEIKEISKRGTPIDIEKELPEIIER 381 >UniRef50_C6A4Y6 2-isopropylmalate synthase 1 n=1 Tax=Thermococcus sibiricus MM 739 RepID=C6A4Y6_THESM Length = 418 Score = 265 bits (678), Expect = 3e-69, Method: Composition-based stats. Identities = 93/394 (23%), Positives = 180/394 (45%), Gaps = 20/394 (5%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 ++V++ D T+R+G+Q + E + IA AL+ +G+D +E+ P S D E+ + + Sbjct: 37 PERVVLHDATIREGQQMPGVAFKRDEIVMIAKALDELGIDRIEL-IPFLSKDDEEAAKEL 95 Query: 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 N+++ + ++D D+A + + + +P +E+IER Sbjct: 96 VDMGLNAKLLSFVSWKKEDTDLALK----LDLEGVVLDFVGNPWQGKVFWNLKPEEIIER 151 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 + A+++ V D + P+ + + V+A A I I DT G +P+ Sbjct: 152 GVNAALYAKDHGLYVVAMPWDDFKAPLDFVEQNVKALTEAHVDRITICDTYGDALPWAME 211 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 ++ L + DK + +H H+D GLA +L AV +G + +NG+GER G SL Sbjct: 212 YVMKRLKKA---ADKTPLELHIHNDFGLATAGALVAVASGVEGLHVTVNGLGERVGLLSL 268 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSG--- 298 EE+ +A++ V T IN ++++ S++V +I + + NK IVG+ F +++G Sbjct: 269 EEIAVALEFLLG---VKTNINLEKLYEISKIVEEISKVKVAVNKPIVGANQFKYTAGWIT 325 Query: 299 -IHQDGVLKNRENYE-IMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE-SEYNLDN 355 +H+ + PE++G + ++ SG + V ++ E+G + Sbjct: 326 WMHRKAREAGKLTGMLPFMPEAVGRQ-LDYVVSKGSGASFVAEKLAELGITVEDPEKMKI 384 Query: 356 LYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPE 389 + + A+ L L I ++ E E Sbjct: 385 IARKVKETANTLKSTVPDSL--LIKIAREVLEKE 416 >UniRef50_Q10Y65 2-isopropylmalate synthase n=1 Tax=Trichodesmium erythraeum IMS101 RepID=Q10Y65_TRIEI Length = 462 Score = 264 bits (676), Expect = 5e-69, Method: Composition-based stats. Identities = 105/351 (29%), Positives = 162/351 (46%), Gaps = 23/351 (6%) Query: 5 VIIFDTTLRDGEQ-ALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 V I D+TLR+G Q A + S ++ L+IA L +G+D++EV PV S + V+ I Sbjct: 2 VQIVDSTLREGRQTAPGINFSWEQSLKIAKLLHSLGIDIIEVCHPVVSIEQKQIVREIVA 61 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 V A AR DI E++K A + F+ + T+ R T+ ++ Sbjct: 62 SNL-CPVIAHARANLADI----EAVKETSAQWVGIFLGINEETRLTRARWTISKIFNCIK 116 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 V A+ V ++ EDA RT L V AI AGA I DTVG P E Sbjct: 117 ESVMYAKTLGLKVRYTAEDASRTDYCLLKSVYSVAIEAGADCICFSDTVGIMEPNEVTET 176 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 I L + + VH H+D GLA+ N+LAA AGA ++ ++NG+GER G Sbjct: 177 IEKLKS---DFSTVPLEVHFHNDRGLAMANALAASDAGAERISSSVNGLGERCGITDTLG 233 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDG 303 +++ + + I I RTS+ V+ P+ N+ I G AF H++ +HQ Sbjct: 234 LLVNLYYKGLRSLPSGEI----IQRTSKYVAAFSRYPVNFNQPISGGNAFIHTAHLHQKA 289 Query: 304 VLKNRENYEIMTPESIGLNQIQLNLTSRSGRAA-------VKHRMDEMGYK 347 V ++ +Y + PE +G + L+ +S + + E+GY Sbjct: 290 VKRDPSSYSWILPEYVGKT---MELSGKSIPSVHSLFLTPIVKCASELGYH 337 >UniRef50_C0GSN3 Pyruvate carboxyltransferase n=1 Tax=Desulfonatronospira thiodismutans ASO3-1 RepID=C0GSN3_9DELT Length = 399 Score = 264 bits (674), Expect = 7e-69, Method: Composition-based stats. Identities = 90/384 (23%), Positives = 169/384 (44%), Gaps = 14/384 (3%) Query: 1 MSQQV-IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQ 59 + ++V ++ DTTLR+G+Q LS+++K I L R+G+D +E G ++ Sbjct: 27 LCKKVFMLIDTTLREGDQRYGLYLSLEQKKVIVDGLHRLGLDELETGSVGRDEELETLIK 86 Query: 60 TIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + ++++ + C ++++ A + I + S +HI +L + Sbjct: 87 YARQHHGSTKISLWSPCRIQELEYA----DSLDPDIISAALPVSDLHIEKRLGLDRCGAL 142 Query: 120 ERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFE 179 + + ED R R A + G + + DT+G P E Sbjct: 143 RLLERTLAGTDKLKAKLSLGLEDFSRADREFALRAALMARDLGVWRVRLSDTLGVMEPGE 202 Query: 180 FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNC 239 + E++ ++ H H+D G+A N+L A+ G V+ ++ GIGERAG Sbjct: 203 LMEAVRPFREKL----DISLAFHGHNDFGMATANALTALSCGVDYVDVSLLGIGERAGIA 258 Query: 240 SLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGI 299 LEEV+ + K H + Q + S V+ + + I ++A++G F SG+ Sbjct: 259 RLEEVLTFLVYNKG----HAGYDVQSLPELSTCVAGLAGVHINPDRAVLGRQLFHCESGL 314 Query: 300 HQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDA 359 H D + K+ + +E P +G+ + +++L +SG AV+ ++ EMG +L+ L Sbjct: 315 HADALYKSFDLFEPFEPHKMGMQR-RISLGRKSGAGAVRGKLMEMGVNPDFVDLEGLVRD 373 Query: 360 FLKLADKKGQVFDYDLEALAFIGK 383 + A KG D + G+ Sbjct: 374 VRRAASIKGSPLDDEQVVSMLQGQ 397 >UniRef50_C8W3E1 Pyruvate carboxyltransferase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8W3E1_DESAS Length = 287 Score = 259 bits (663), Expect = 2e-67, Method: Composition-based stats. Identities = 85/279 (30%), Positives = 137/279 (49%), Gaps = 11/279 (3%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 +V I DTTLRDGEQ+ + S KEK++IA L+ +GV+ +E+G P + +++ +IA Sbjct: 3 KVCIVDTTLRDGEQSPGVAFSAKEKIKIAQYLDLLGVEQIELGIPAMGGIEVDAISSIAS 62 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAI 123 +R+ R DI + +H S + I KL + V++ Sbjct: 63 LDLKARLTTWNRLHLSDIRASL----SCRVKNLHICAPVSDIQIEYKLNKSRLWVLDCLK 118 Query: 124 YMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGI 183 ++ A++Y + EDA R L A GA + DTVG PF Sbjct: 119 RAIRYAKDYGCWISVGAEDASRADPEFLLEYALLAQEMGAERLRYADTVGVLEPFSTYRE 178 Query: 184 ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEE 243 +S L +++ K + H H+D GLA N++AAV+AG R ++ +NG+GERAGN ++EE Sbjct: 179 LSWLKDKL----KIELEFHGHNDFGLATANTVAAVNAGVRFIDVTVNGLGERAGNANMEE 234 Query: 244 VIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIP 282 V+ AI++ I ++ S V++ N +P Sbjct: 235 VVAAIRMSCGIGMNWAN---DKMKALSSYVARASNRKMP 270 >UniRef50_C1XGU5 Isopropylmalate/homocitrate/citramalate synthase n=2 Tax=Meiothermus RepID=C1XGU5_MEIRU Length = 422 Score = 258 bits (660), Expect = 3e-67, Method: Composition-based stats. Identities = 99/392 (25%), Positives = 182/392 (46%), Gaps = 25/392 (6%) Query: 2 SQQVIIFDTTLRDGEQAL------QASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDF 55 + ++ I DTT RDG+Q+ + +++EK + L +GV E PV + Sbjct: 17 AHRIEIVDTTFRDGQQSPLLFDTEKYRFTLEEKKVLMTGLLELGVTHFEFFSPVVGVAEA 76 Query: 56 ESVQTIARQV-----KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATK 110 + V+ + K R A RC +DI+ A E+ ++ ++ SP+ Sbjct: 77 QDVRELIAHASALTQKPLRFLAHCRCNLQDIEQALET----GCNGLNLYLGVSPLAQQHN 132 Query: 111 LRSTLDEVIERAIYMVKRARNYTDD--VEFSCEDAGRTPIADLARVVEAAINAGATTINI 168 + +L+E ++ ++ R D + FS EDA RTP+ D+ R+ +A T+ + Sbjct: 133 AQKSLEESVQLVQEVIATTRAAHPDLYIRFSAEDAFRTPLEDIFRLYDAIYPY-VNTLGM 191 Query: 169 PDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGA 228 PDTVG P + + +++ L +R PN + H H+D GLA+ N +AAV AG R V+ + Sbjct: 192 PDTVGIAEPEDVSAVVAQLRQRYPN---VALECHFHNDRGLALANVIAAVRAGVRYVDAS 248 Query: 229 MNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIV 288 + G+ ER+G S+ V+ + R + N + + + L++ I +P + + Sbjct: 249 IWGLAERSGIPSVTGVLFNLSKRY--PEIAQQYNLSQCYPLNVLMASILGTLVPYTEPVS 306 Query: 289 GSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEM-GYK 347 + H++G+HQ VL ++ YE G+++ QL L SG + + + E+ G+ Sbjct: 307 LTNR-THTAGVHQKAVLNEKKVYEAHNLHDFGVDKNQLLLGPLSGWNLIYYYLKEVEGFV 365 Query: 348 ESEYNLDNLYDAFLKLADKKGQVFDYDLEALA 379 S+ + F + G+ + L Sbjct: 366 ISKEQAKQIAQEFKGRTSEIGRRKKPEELLLE 397 >UniRef50_D2JWV4 Putative homocitrate synthase n=1 Tax=Filobasidiella depauperata RepID=D2JWV4_9TREE Length = 465 Score = 257 bits (658), Expect = 6e-67, Method: Composition-based stats. Identities = 89/396 (22%), Positives = 153/396 (38%), Gaps = 56/396 (14%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 I ++TLR+GEQ A +++ K++IA L+ GV+ +E+ P +SP + I + Sbjct: 68 KIIESTLREGEQFANAFFNLETKIKIAKMLDEFGVEYIELTSPAASPESRAHCEAICKLG 127 Query: 66 -KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 K +++ RC D +A E+ + I TS + + Sbjct: 128 LKKTKILTHIRCHMDDARLAVET----GVDGVDVVIGTSSFLREHSHGKDMAWI------ 177 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 +T + + G + + DTVG P + ++ Sbjct: 178 -------------------TKTTVDKI----------GVNRVGVADTVGCADPRQVYDLV 208 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLA-----------VGNSLAAVHAGARQVEGAMNGIG 233 L V I H H+D G + N+ AA+ AGA V+ ++ GIG Sbjct: 209 RTLRGVV----SCDIETHFHNDTGCGKASTLDESTAPIANAYAALEAGATHVDTSILGIG 264 Query: 234 ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAF 293 ER G L +I + V D V + N + V++ + +P N I G AF Sbjct: 265 ERNGITPLGGLIARMMV-ADPDYVKSKYNLTMLRELENTVAEAVEVQVPFNNYITGFCAF 323 Query: 294 AHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNL 353 H +GIH +L N YEI+ P G+ + +G AVK R++++ ++ + Sbjct: 324 THKAGIHAKAILANPSTYEILNPADFGMTRYVSIGHRLTGWNAVKSRVEQLNLNLTDEQV 383 Query: 354 DNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPE 389 + +LAD + Q + L + Sbjct: 384 KDATAKIKELADVRTQSMEDVDMILRIYHTGIHSGD 419 >UniRef50_A4QUQ8 Putative uncharacterized protein n=1 Tax=Magnaporthe grisea RepID=A4QUQ8_MAGGR Length = 633 Score = 257 bits (657), Expect = 6e-67, Method: Composition-based stats. Identities = 103/529 (19%), Positives = 188/529 (35%), Gaps = 52/529 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +++ I T LRDG Q+L A L+ +K + L +G +EV FP +S +FE + Sbjct: 10 ITKAPIWLSTDLRDGNQSLTAPLNSDQKFEFFKLLVEIGYKEIEVSFPAASNVEFEFTRR 69 Query: 61 IARQV----KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 + + R+ ALA + ++L+ A+ + T+I S + + + Sbjct: 70 LVETPGAVPDDVRLRALAPTRNDFLKRTVDALEGAKRATVCTYICVSDKMLKYQ-GFSRA 128 Query: 117 EVIERAIYMVKRARNYT---------DDVEFSCEDAGRTPIADLARVVEAAINAGA---- 163 IE+A+ V+ R+ T D+ F E + + EA + A Sbjct: 129 RAIEQAVGAVRYLRSITKDNPDTKTRWDLAFGLESYNESDQDFALAMTEAVMGAWEASAD 188 Query: 164 --TTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAG 221 + + + P FA + + + +IS+HTH D G + + AG Sbjct: 189 DQMWVVLATSTEVATPNVFADQVETFIAGLSAPENVLISIHTHSDRGCGAAAAELGMLAG 248 Query: 222 ARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPI 281 A VEG + G GERAGN L + + + R + ++ +++ Q+ + + Sbjct: 249 AHMVEGCLFGNGERAGNVDLVTLALNLYTRG----ISPHLDFSDLYAVRDRYEQLTGLQV 304 Query: 282 PANKAIVGSGAFAHSSGIHQDGVLKNREN-----------------YEIMTPESIGLN-Q 323 A G A SG HQ+ + K Y + P+ +G+ Sbjct: 305 TARTPYAGEYALQAFSGHHQNIIRKGMGLRLRAEAEGRPAPVWDIPYLPVDPQDLGIPID 364 Query: 324 IQLNLTSRSGRAAVKHRMDEM-GYKESEYNLDNLYDAFLKLADKKGQVFDYDL---EALA 379 + + S+SG+AA + G + + L + + D + Sbjct: 365 HIIRVNSQSGKAAATWILSRRWGLDLPVDMQVHFGRRLMALCEALAREISQDELLGLFTS 424 Query: 380 FIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKL--ACGEEVKAEAANGNGPVDAVYQAIN 437 G + + L + +VQ SN L A G+ A Q++N Sbjct: 425 TYGLETPDRPSHHLGHLTVQRSSNGRGYVVDGLISPIDGVKLVLAGLGSDLATAALQSLN 484 Query: 438 RITE---YNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATD 483 TE V++ G+ + G + + Sbjct: 485 IDTEGKAVAVKIQDTQQLNNDFGRGRYC-ALATCEVASQVQWGYFIDEN 532 >UniRef50_P70728 Homocitrate synthase n=1 Tax=Azospirillum brasilense RepID=NIFV_AZOBR Length = 376 Score = 257 bits (656), Expect = 8e-67, Method: Composition-based stats. Identities = 101/364 (27%), Positives = 159/364 (43%), Gaps = 33/364 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+ II DT RDGEQ + ++ EK+ IA AL+ GV +E+G P + E ++ Sbjct: 1 MAGSTIINDTHARDGEQTAGVAFTLDEKIAIAQALDEAGVAELEIGIPAMGREERERIRA 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 +A +R+ R + D+ + ++ + + S +HI KL + + Sbjct: 61 VASLGLKARLMVWCRMHDTDLKARSTAVAPS------LSVPVSDIHITKKLNGSRAWALR 114 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 VK AR++ +V ED+ R + L + AA A DT+G PF+ Sbjct: 115 EIERKVKTARDHGLEVSLGGEDSSRADMDFL---IAAATVAQRPRFRFADTLGVLDPFQH 171 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGN---SLAAVHAGARQVEGAMNGIGERAG 237 A + I H H LA +LAAV GA V +NG+GERAG Sbjct: 172 ARL-----HLTAAATDPEIGYHAH-TPRLANATAWVTLAAVLGGATHVNTTVNGLGERAG 225 Query: 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 N LEEV++++KV ++ + + S LV + N P+ NK+IV F H + Sbjct: 226 NAPLEEVVVSLKVLYGQ---DCGVDTRALGAISDLVERASNRPVAVNKSIVRDAVFTHEA 282 Query: 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHR-----MDEMGYKESEYN 352 GIH DG+L +R I TP G ++ S A++ R + ++G + Sbjct: 283 GIHVDGLLTDRAPTRISTPPRWG-------ASTASCWASIPARGGEDGLRQLGIACDDAT 335 Query: 353 LDNL 356 Sbjct: 336 AQAC 339 >UniRef50_C0Z7H0 Alpha-isopropylmalate/homocitrate synthase family protein n=5 Tax=Bacillales RepID=C0Z7H0_BREBN Length = 472 Score = 256 bits (654), Expect = 2e-66, Method: Composition-based stats. Identities = 93/322 (28%), Positives = 155/322 (48%), Gaps = 13/322 (4%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 + I D TLR+GEQ + ++K++I LE ++++EVG P S D E + +A Sbjct: 2 KPFQILDATLREGEQQAGVRFTCEDKIRILHLLESYQINLIEVGHPGISALDEEICRKVA 61 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD-EVIER 121 + + +++ AR +++ A K A+A + + + + + I TK R + ++E+ Sbjct: 62 QSARRAQILMHARATVEEVHAA----KRAKADWVGIWASINDVSIQTKFRHHEESYILEK 117 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 V A+ V F+ EDA RT ++ + AA+ AGA I++ DTVG P Sbjct: 118 VQQAVIEAKKLGLQVRFTIEDASRTEWEKISSLGYAALQAGADRISLADTVGIWEP---- 173 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 + R I VH H+D GLA N+LAA+ AGA ++ + GIGERAG L Sbjct: 174 DTCKKIVTRAIEEFGCEIEVHLHNDFGLAQANALAAIDAGASVIDATILGIGERAGITDL 233 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 ++ +A++ ++ + I Q + + I G AF H+S H Sbjct: 234 IQLTVALQKLRN----DHRYSLDRIPELVQAIRLTTGYRPDELRPITGQNAFTHTSAYHV 289 Query: 302 DGVLKNRENYEIMTPESIGLNQ 323 V +N + YE + PE+IG + Sbjct: 290 QAVKRNSKAYEPLPPETIGRTR 311 >UniRef50_A8A943 Pyruvate carboxyltransferase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=A8A943_IGNH4 Length = 488 Score = 254 bits (650), Expect = 4e-66, Method: Composition-based stats. Identities = 92/412 (22%), Positives = 172/412 (41%), Gaps = 35/412 (8%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMG-----VDVMEVGFPVSSPGDF 55 + ++ I DTT RDG+QA + +V++ +++ L +G + E F + + D Sbjct: 60 LPSEIWITDTTFRDGQQA-REPYTVEQIVRLYKYLHELGGPLGKIKTTE--FFLYTEKDK 116 Query: 56 ESVQTIARQV-KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRST 114 E+V+ + K R ++++ + +K A + S HI K +++ Sbjct: 117 EAVRRVKELGYKYPIPTGWIRAKKEELSL----VKEAGLEETGILASISDYHIYFKFKAS 172 Query: 115 LDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPI-----ADLARVVEAAINAGATT-INI 168 +V+E+ + +V+ A ED R I + ++++ + G + Sbjct: 173 RGKVVEKYLSVVEEALKMDIIPRVHLEDITRANIFEVVVPFVRKLMKLSERYGLPVKVRY 232 Query: 169 PDTVGYTMPFEFAGI------ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGA 222 PDT+G +P A + ++ + V + + H H+D L V N+++A GA Sbjct: 233 PDTLGVGVPIVEAMLPRSIPKLTWVLRHVCGVPSEWLEFHGHNDFHLGVANAVSAWLYGA 292 Query: 223 RQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIP 282 G + GIGERAGN +E ++ A K + +N + I ++ +P Sbjct: 293 GLNNGTLLGIGERAGNVPIEALVFAYAQLKHGFD---GMNTKVITEIAKYYRDELGYEVP 349 Query: 283 ANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMD 342 IVG +GIH DG+LKN E Y E I + + +T +G A + + ++ Sbjct: 350 PYYPIVGRNFAVTRAGIHADGLLKNPETYLPFDTEGILGVKPGVAITPYAGLAGIVYWIN 409 Query: 343 EMGYKESEYNLDN-------LYDAFLKLADKKGQVFDYDLEALAFIGKQQEE 387 + + E + +Y +K + D E LA + K E Sbjct: 410 KTFDLKGEEQVSKKDPKVQAIYKDVMKQFEHGRLTALSDAEMLALVAKHAPE 461 >UniRef50_Q46A98 Homocitrate synthase n=2 Tax=Methanosarcina RepID=Q46A98_METBF Length = 287 Score = 253 bits (647), Expect = 1e-65, Method: Composition-based stats. Identities = 82/286 (28%), Positives = 133/286 (46%), Gaps = 11/286 (3%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I DTTLRDGEQ+ SV+E++ I AL++ V +E G P + E ++ + Sbjct: 9 IIDTTLRDGEQSAGVVFSVEERMNIISALDKAKVKWIEAGIPAMGKQECEDLKLMLNLPI 68 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 S + A R +D+ + + +H + S +HI KL+ + V+++ + Sbjct: 69 KSNLIAWNRANLEDLKASID----CGFKFVHVSLPVSDLHIEHKLQKSRTWVLDQLKKCM 124 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 + ++ + EDA R L + A + GA I DTVG F I Sbjct: 125 EYLQSCKVTIIVGAEDASRADPEFLLQYAGIAASYGAIRIRYSDTVGCLDHFTTYRKIKE 184 Query: 187 LYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIM 246 + + P + +H H+D GLAV N+LAA AGA+ + G+GERAGN S+EE Sbjct: 185 IADHSP----PPVEIHAHNDFGLAVANTLAAYKAGAKFASVTVTGLGERAGNASMEETAF 240 Query: 247 AIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292 ++K N I + + +++VS+ + K +VGS A Sbjct: 241 SLKR---FYNYDCGIELEALPFLAEMVSKASERTLFPYKPLVGSLA 283 >UniRef50_A6FZR1 Homocitrate synthase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6FZR1_9DELT Length = 382 Score = 253 bits (647), Expect = 1e-65, Method: Composition-based stats. Identities = 108/366 (29%), Positives = 175/366 (47%), Gaps = 13/366 (3%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 + D+TLR+G Q+ + KL IA L GVD +EVG PVSS + +A Sbjct: 2 RLVDSTLREGLQSDTRPVDSARKLDIAALLAAFGVDCIEVGNPVSSERARADARRLAGLD 61 Query: 66 KN-SRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 +RV A RC +DI A ++ ++ FI SP+ L +LDE+IE A+ Sbjct: 62 LGSTRVLAHVRCHPEDIRAAVDT----GVDGLNLFIPCSPLLRHASLGRSLDELIEIAVG 117 Query: 125 MVKRARNYTDDVE--FSCEDAGRTPIADLARVVEAA-INAGATTINIPDTVGYTMPFEFA 181 ++ AR ++E + ED+ RTP+ +L R A + + DTVG P Sbjct: 118 ALELARALRPELELRITPEDSFRTPVPELERFCGAVTSRVRVDRVGLADTVGVAHPRAVE 177 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 + L +R + H H+D G AV N+L A AGA V+ + G+GER G +L Sbjct: 178 ARFARLRQRF----DLDLEFHGHNDTGCAVANALLAREAGATHVDVTVLGLGERNGITAL 233 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 E + A+ + D VH + + + ++ V+ + IP N +VG+ +FAH +G+H Sbjct: 234 EGFVAAL-LVHDPDAVHGRLRLELLPLLTRAVADAFGVEIPRNSCLVGANSFAHKAGVHT 292 Query: 302 DGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFL 361 + +L++R +YE + P+ +G+ + L +G + + R +G S L L + Sbjct: 293 NAMLRDRRSYEFVDPQLMGVERRLLAGHEMTGASVLGARAQALGLDLSPEQLRRLAASVR 352 Query: 362 KLADKK 367 A Sbjct: 353 TSASHG 358 >UniRef50_B8DR73 Pyruvate carboxyltransferase n=3 Tax=Desulfovibrio vulgaris RepID=B8DR73_DESVM Length = 455 Score = 252 bits (644), Expect = 2e-65, Method: Composition-based stats. Identities = 102/394 (25%), Positives = 169/394 (42%), Gaps = 22/394 (5%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 ++ DTTLR+GEQ+ LS+ ++ ++ L +GV EVG+ + + AR Sbjct: 1 MLLDTTLREGEQSFGTYLSMADRERVLRGLAAVGVPEAEVGW-AGREDLTDMLALSARVA 59 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 A RC D+ A A R+ + S H+A +L +++ Sbjct: 60 PGLAAAAWCRCRPGDLRAAV----ACGASRVCVGVPVSDAHLARRLGLGRAALLDLLAAT 115 Query: 126 VKRARNYTDD-VEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 + AR + V EDA R A + V A GA + + DTVG P E A ++ Sbjct: 116 LAEARMLGIEHVTVGMEDASRADRAFVFAVACHAAAHGAHRVRLSDTVGLYTPLEVADVV 175 Query: 185 SGLYERV---------PNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGER 235 L + P + I H H+D G+A N+L A+ GA + ++ G+GER Sbjct: 176 RALRAELEGARQDDTAPRARRVSIGTHFHNDCGMATANALTALECGADCADVSVLGLGER 235 Query: 236 AGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAH 295 AG LEE+ A+ VR + V+Q ++ +P + + G FA Sbjct: 236 AGVARLEELAAALVVRGRAR-----FELAPLRALCGQVAQAASLSVPRHWPVAGRDIFAV 290 Query: 296 SSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDN 355 SG+H GV ++ +E PE +G ++ ++ + +SG AAV + E+ L Sbjct: 291 ESGLHAHGVRRDPSLFEPFPPELVGDSR-RMGVGRKSGVAAVAAALAELSILPPPDELPA 349 Query: 356 LYDAFLKLADKKGQVF-DYDLEALAFIGKQQEEP 388 + +A L+ + +L +A +GK P Sbjct: 350 IVEAVRDLSATLRRPLTPAELAEVAGLGKHHAPP 383 >UniRef50_B1L5J0 2-isopropylmalate synthase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5J0_KORCO Length = 426 Score = 251 bits (640), Expect = 7e-65, Method: Composition-based stats. Identities = 101/407 (24%), Positives = 170/407 (41%), Gaps = 38/407 (9%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERM----GV-DVMEVGFPVSSPGDFE 56 S ++I DTTLRDG+Q + S +E ++I L + GV +E+ FP +S D E Sbjct: 22 SHDLLITDTTLRDGQQGSR-PFSKEECIKIYSILSELDGGSGVIRDIEL-FPYTSK-DRE 78 Query: 57 SVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 ++ + R +D+ + +K + S HI KLR + Sbjct: 79 VIKALRDFGTTPNPIGWIRARIEDLKL----VKECGLDTTVLLTSVSDYHIHYKLRMSRT 134 Query: 117 EVIERAIYMVKRARNYTDDVEFSCEDAGRTPIA-DLARVVEAA-----INAGATTINIPD 170 E E+ + ++ ++ + ED R+ I + +E G + I D Sbjct: 135 EAREKFLSAIREGLRMGLKLKVAMEDITRSDIYGFVLPFIEDILRISEREGGEVSFKISD 194 Query: 171 TVGYTMPFE-------FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGAR 223 T+G +PF +I L E + + I H H+D L V N LAA GA Sbjct: 195 TLGLALPFPESPLPRGVPRLIRSLIEEM-GLRSEQIEFHGHNDFHLVVANHLAAWLYGAS 253 Query: 224 QVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 + GIGERAGNC LE + + +N + + + + S+ IP Sbjct: 254 ISNCTLMGIGERAGNCPLEAMAIMHSQLSGER----KLNLKALSKIIDVFSE-MGFRIPE 308 Query: 284 NKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRM-D 342 I+G AF +GIH DG+LKN Y P IG + ++ SGR+ + + + Sbjct: 309 FYPILGENAFKTKAGIHIDGLLKNPAIYLPFDPTIIGRPYS-IEISPYSGRSGIIYWLAR 367 Query: 343 EMGYK-----ESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQ 384 ++ + + + ++ Y LK+ ++ + EAL+ + K Sbjct: 368 KLNIEEWESLKEDPRVELAYREMLKIFEEGRTEPLSEEEALSLLKKY 414 >UniRef50_D1J0N9 Whole genome shotgun sequence of line PN40024, scaffold_124.assembly12x (Fragment) n=1 Tax=Vitis vinifera RepID=D1J0N9_VITVI Length = 974 Score = 250 bits (639), Expect = 9e-65, Method: Composition-based stats. Identities = 96/297 (32%), Positives = 157/297 (52%), Gaps = 22/297 (7%) Query: 241 LEEVIMAIKVRKD--ILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSG 298 V+MA+K R + + ++T IN + I +TS++V++ + + +KAIVG+ AFAH SG Sbjct: 677 TYMVVMALKCRGEKALGGLYTGINIRHIVKTSKMVAEYSGLQVQPHKAIVGANAFAHESG 736 Query: 299 IHQDGVLKNRENYEIMTPESIGL---NQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDN 355 IHQDG+LK++E YEI++PE IGL N+ + L SGR A+K R+ E+GY+ LD+ Sbjct: 737 IHQDGMLKHKETYEIISPEDIGLFRSNESGIVLGKLSGRHALKSRLLELGYEIEGMELDD 796 Query: 356 LYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKL-AC 414 ++ F ++A+KK + D D+ AL + ++L V G+ ++TA VKL Sbjct: 797 IFWRFKEVAEKKKNLTDVDVIALVSDEIF-QPKVFWKLGDLQVTCGTLGLSTATVKLIDA 855 Query: 415 GEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNG-- 472 + + G GPVD+ Y+AI+ + + V L++Y L A G DA+ ++ Sbjct: 856 DGQKHVACSVGTGPVDSAYKAIDLLVKEQVTLLEYGLNAVTEGIDAIATTRVLIRGEKNH 915 Query: 473 ------------RRFHGVGLATDIVESSAKAMVHVLNNIWR-AAEVEKELQRKAQHN 516 R F G G DIV SS +A + LN + + + ++ + Sbjct: 916 TLTNALTGETVHRSFSGTGAGMDIVVSSVRAYISALNKMLGFKDQSKPKVSADRSQD 972 Score = 211 bits (537), Expect = 5e-53, Method: Composition-based stats. Identities = 109/265 (41%), Positives = 148/265 (55%), Gaps = 33/265 (12%) Query: 23 LSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSR--------VCALA 74 ++ KEKL IA L ++GVD++E GFP +S D ++V+ IA++V N+ +C LA Sbjct: 1 MTSKEKLDIARQLAKLGVDIIEAGFPAASKDDLDAVKIIAKEVGNAVDENGHVPVICGLA 60 Query: 75 RCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTD 134 RC DI A E+ KL+ + EVIE A MVK AR+ Sbjct: 61 RCNRNDISTAWEA---------------------YKLKKSEKEVIEIAREMVKYARSLGC 99 Query: 135 D-VEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPN 193 D VEFS EDAGR+ L +++ I AGATT+NIPDTVGYT+P EF +I+ + P Sbjct: 100 DDVEFSPEDAGRSEREFLYKILGEVIKAGATTLNIPDTVGYTVPNEFGQLIADIKSNTPG 159 Query: 194 IDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKD 253 I+ IIS H +DLGL+ N++A AGARQVE +NGIGERAGN SLEEV + ++ Sbjct: 160 IENVIISTHCQNDLGLSTANTIAGACAGARQVEVTINGIGERAGNASLEEVCLIYRLAPG 219 Query: 254 ILNVHTAINHQEIWRTSQLVSQICN 278 + T + S +S I Sbjct: 220 LC---TDTQLNGVINLSMNLSGIWR 241 >UniRef50_Q3IV11 Isopropylmalate/homocitrate synthase n=1 Tax=Rhodobacter sphaeroides 2.4.1 RepID=Q3IV11_RHOS4 Length = 336 Score = 250 bits (638), Expect = 1e-64, Method: Composition-based stats. Identities = 97/313 (30%), Positives = 159/313 (50%), Gaps = 12/313 (3%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIA 62 ++ +I D TLR+G QA SV + + IA AL+ +GVD++E+G P++ P + + + +A Sbjct: 4 KRTLINDATLREGNQASGVRFSVHDSVAIATALDGIGVDMIEIGHPLAGPYEHQRTEAVA 63 Query: 63 RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIA-TKLRSTLDEVIER 121 + +++ A AR DI E++ A + F+ + + + + E+I Sbjct: 64 KLGLGAKIIAHARAHRTDI----EAVSRTGATWVGIFLGVNDITTKARVIGRSTTELIRM 119 Query: 122 AIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFA 181 VK A++ ++ +SCEDA RT L V AAI+AGA I DT+G P E A Sbjct: 120 VADAVKVAKDCGLNIRYSCEDASRTNTLFLVDVFGAAIDAGADRICYADTLGIAEPAEVA 179 Query: 182 GIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSL 241 ++ + P+ + + VH HDD GLA+ NSLAA+ AG + ++N +GER G L Sbjct: 180 RKVTLMKSEFPDAE---VEVHLHDDRGLAMANSLAAIDAGVDSISVSVNALGERCGITDL 236 Query: 242 EEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQ 301 +++ + R + + E+ S+LV+ N P A + IVG AF H S +HQ Sbjct: 237 ATLLVNLGFRGERALP----DISELRALSRLVAMSSNTPFDALRPIVGDNAFKHGSKLHQ 292 Query: 302 DGVLKNRENYEIM 314 Y+ + Sbjct: 293 RATQYEPRAYDWI 305 >UniRef50_B2KBD6 Pyruvate carboxyltransferase n=7 Tax=Bacteria RepID=B2KBD6_ELUMP Length = 416 Score = 249 bits (635), Expect = 2e-64, Method: Composition-based stats. Identities = 107/404 (26%), Positives = 176/404 (43%), Gaps = 30/404 (7%) Query: 1 MSQQ-VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPG--DFES 57 MS + + I D T RDG Q + L+ +K + + L+ MG+ E GFP + + Sbjct: 1 MSDKLIYIVDVTNRDGVQTSRLGLAKLQKTLVNIYLDEMGITQSEFGFPTTQHEINYLNA 60 Query: 58 VQTIARQV--KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKL--RS 113 +A + K + + R +E D+ +A +++ + ++ I+TS I K R Sbjct: 61 NLDLAERGGIKKTVLSGWMRALESDVVLAFKNV--PKLKTVNLSISTSDQMIQGKFGGRK 118 Query: 114 TLDEVIERAIYMVKRARNYTDD-VEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTV 172 T ++I + VK+A + V + EDA RT L AA AGA + DT+ Sbjct: 119 TRKDIINQMTAAVKKAYECGAELVGVNSEDASRTDQEYLVEFALAAKAAGAKRLRYCDTL 178 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLA----AVHAGAR-QVEG 227 GY P ++ L +R + +H H+DLG+AV NS+ A+ G + Sbjct: 179 GYDSPDVAYSRLNDLAKRTC----LDLEMHFHNDLGMAVANSVRGAQGAIDGGVNAYINT 234 Query: 228 AMNGIGERAGNCSL-EEVIMAIKVRK--DILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 A+NG+GER+GN L V+ +K + I+ +IW ++ S +PIP N Sbjct: 235 AVNGMGERSGNADLACCVLAVLKSSGFSGKYKIDPDIDMSKIWPLAKYTSYSFGVPIPIN 294 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQ-------LNLTSRSGRAAV 337 VG AFAH SGIH DG LK+R NYE+ E +G + + + G Sbjct: 295 YPAVGGNAFAHESGIHADGALKDRRNYELYDYEELGRGEPEVIETGRMITTGEYGGIKGF 354 Query: 338 KHRMDEMGYK-ESEYNLDNLYDAFLKLADKKGQVFDYDLEALAF 380 + +++ + + E N+ + + Sbjct: 355 RDVYEKLSIEFKDEKEARNILELVRYANVHTQLPLMDSELRFIY 398 >UniRef50_Q7X1M2 Homocitrate synthase (Fragment) n=1 Tax=Leptospirillum ferrooxidans RepID=Q7X1M2_9BACT Length = 304 Score = 249 bits (635), Expect = 3e-64, Method: Composition-based stats. Identities = 87/296 (29%), Positives = 132/296 (44%), Gaps = 11/296 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + DTT+RDG Q+ K+ I L R+GV +EVG P + E ++ + Sbjct: 18 PVFVDTTIRDGGQSPGVFFDRPTKMVIVTTLSRIGVQEIEVGTPCLGDHEIEDLRALLSL 77 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 + R +E D ES R+H TS H A+ +++ER Sbjct: 78 PVPVELFPWLRPLEAD----FESALGLGFKRVHVSFPTSDAHRASVQNMGRPDIVERVRK 133 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 V R V EDA R P+ L + A +G + DTVG P E I Sbjct: 134 TVLRMTGEGCRVSIGLEDASRAPMDFLKEFIAAVRESGGIRVRYCDTVGKHHPAEIIERI 193 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 S L + I +H H+DLG+A N+++A H+GAR + + G+GERAGN ++EEV Sbjct: 194 SELSKE-----GLPIEIHCHNDLGMATANTVSACHSGARYLSTTVTGVGERAGNAAMEEV 248 Query: 245 IMAIKVRKDILNV--HTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSG 298 A+ + ++ +AI+ + S+ + + + IVGS F HSSG Sbjct: 249 AFALACERGDPSLPESSAIDLPGLAHISRWLYGAIRRTLSPYRPIVGSRIFHHSSG 304 >UniRef50_C9YAE2 Putative uncharacterized protein n=1 Tax=Curvibacter putative symbiont of Hydra magnipapillata RepID=C9YAE2_9BURK Length = 285 Score = 248 bits (633), Expect = 4e-64, Method: Composition-based stats. Identities = 124/221 (56%), Positives = 159/221 (71%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M+ ++IIFDTTLRDGEQ+ AS++ EKL+IA LER+ VDV+E GF SS GDFE+VQ Sbjct: 1 MTDKLIIFDTTLRDGEQSPGASMTRDEKLRIARQLERLRVDVIEAGFAASSNGDFEAVQL 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 IA +K+S VC+L+R ++DI AAE+LK A + RIHTFIATS +H+ KLR T ++V+E Sbjct: 61 IANSIKDSTVCSLSRANDRDIARAAEALKGANSARIHTFIATSALHMEKKLRMTPEQVLE 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 +A V+ ARN D+EFS ED R+ L RV+EA I GA+TIN+PDTVGY +P + Sbjct: 121 QAKQSVRFARNLVADIEFSPEDGYRSDPDFLCRVLEAVIAEGASTINVPDTVGYAVPELY 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAG 221 I L ER+PN DKAI SVH H+DLG+AV NSLA V G Sbjct: 181 GNFIKNLRERIPNSDKAIWSVHCHNDLGMAVANSLAGVKIG 221 >UniRef50_A8TLL5 Homocitrate synthase n=1 Tax=alpha proteobacterium BAL199 RepID=A8TLL5_9PROT Length = 385 Score = 248 bits (633), Expect = 4e-64, Method: Composition-based stats. Identities = 111/394 (28%), Positives = 171/394 (43%), Gaps = 13/394 (3%) Query: 1 MS-QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQ 59 M V+I D+TLR+GEQ + A S KL+IA AL GV+ +EV P +S Sbjct: 1 MPLSDVVIVDSTLREGEQFVHADFSRDAKLEIARALTSFGVNYLEVTSPAASRRSRTDAA 60 Query: 60 TIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 TIA + V A RC + D +A ++ A +H +ATSP+ A + EV+ Sbjct: 61 TIANAGLPAMVAAHIRCHKDDAAIAIDTGVGA----LHMVMATSPILRAASHGKAIAEVV 116 Query: 120 ERAIYMVKRARNY--TDDVEFSCEDAGRTPIADLARVVEAAINAG-ATTINIPDTVGYTM 176 A + + RN ++ FS EDA R P+ DL V + DT G Sbjct: 117 RIAAEVGEFVRNRAPNIELRFSSEDAFRCPLNDLMNVYLPLSELRLFDRFGLADTTGAAT 176 Query: 177 PFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERA 236 P A +++ L + I H H+D+G A+ N+ AA GA + + G+GER Sbjct: 177 PDRVAEVVNLLRR----LTTTPIEFHGHNDIGCAIANAHAAAMNGATHINTTVLGLGERN 232 Query: 237 GNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHS 296 G LE +I + D E+ + V+++ + +P N+ +VG AF+H Sbjct: 233 GITPLEGLIAVMYA-ADRGRTMAQFQLSELPALCRRVAELAGVAVPFNQVLVGESAFSHK 291 Query: 297 SGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNL 356 +G+H V + +YE M P GL + +G AV+ R D +G + + +L Sbjct: 292 AGMHTKAVHNDPRSYEAMDPSDFGLTREIAISHRLTGWNAVRVRADALGLRLALADLKEA 351 Query: 357 YDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEH 390 AD+ D L + H Sbjct: 352 TSRVKSAADEHTLSLDDVDRILTDVAALATARPH 385 >UniRef50_C5AK37 Isopropylmalate/homocitrate/citramalate synthase n=7 Tax=Proteobacteria RepID=C5AK37_BURGB Length = 456 Score = 247 bits (630), Expect = 8e-64, Method: Composition-based stats. Identities = 109/446 (24%), Positives = 183/446 (41%), Gaps = 35/446 (7%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I D +LR+G Q +Q + +++ +A + GVD++E G P SP + E V+ + R Sbjct: 5 IIDCSLREGCQTIQCNFDIEQSEILARKIAEFGVDMIECGHPKISPYELERVRAVVRVSP 64 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLR-STLDEVIERAIYM 125 + A ARC +DID AES A + F + +P+ +ATK D+V+ Sbjct: 65 LPVL-AHARCRSEDIDAVAES----GAAWVGMFASFNPVSLATKFGGMGKDQVLALFEAS 119 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 ++ A++ V + EDAGRT +DL R+ + A+ AGA I D+VG +P E I++ Sbjct: 120 IRYAKSRGLSVRATIEDAGRTEQSDLFRIYQTAVAAGADRICFADSVGALLPSETYDILA 179 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245 L + H H+D GLA+ +SL A+ AG + + NGIGERAG ++ Sbjct: 180 LLRHEF---RQVQFEYHVHNDRGLALASSLEALRAGVEWISTSCNGIGERAGVTDTFQLA 236 Query: 246 MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVL 305 ++ R + + + S+LV + + IVG FAH+S +H+ Sbjct: 237 ALLESRFG----DASRRLDKARQLSELVRVFSRIDGSPMQPIVGDNVFAHASRLHRIACE 292 Query: 306 KNRENYEIMTPESIGLNQIQLNLTSRS---------GRAAVKHRMDEMG-----YKESEY 351 K+ Y I +P G +++ +++ + R G Sbjct: 293 KDASAYNIHSPALAGDAEVREKHPPMHEQDLFLVPFEKSSTELRYHRHGPGKRFVMLDHR 352 Query: 352 NLDN-----LYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQ---SGSN 403 L + +A+ + D + + E +R V Sbjct: 353 LLSASPFYFIARKVEVIAENEEGHVDTHRHNCDSVFMFLGDDEDYRGLTVEVSIAGVSRT 412 Query: 404 DIATAAVKLACGEEVKAEAANGNGPV 429 + A + G E G G Sbjct: 413 LTSPATAFVPAGAEHSYRFVAGKGSF 438 >UniRef50_A9HXK1 2-isopropylmalate synthase (Fragment) n=1 Tax=Roseobacter litoralis Och 149 RepID=A9HXK1_9RHOB Length = 250 Score = 246 bits (627), Expect = 2e-63, Method: Composition-based stats. Identities = 100/242 (41%), Positives = 145/242 (59%) Query: 259 TAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPES 318 T IN + S +VS++ MP+ NKAI+G AFAHSSGIHQDG LK+RENYEIM PE Sbjct: 9 TNINAKHFSDISNMVSRMMRMPVQPNKAIIGQNAFAHSSGIHQDGFLKHRENYEIMNPED 68 Query: 319 IGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEAL 378 +G+N + LT+RSGR A+KH ++ +GY+ NLD +Y+ FL LAD+K + D D+ +L Sbjct: 69 VGINSADIILTARSGRHALKHHLERLGYEIERLNLDQVYERFLILADEKKAISDDDIHSL 128 Query: 379 AFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINR 438 GK+ ++L V G TA++KL K A+GNGPV+A AI Sbjct: 129 MSDGKEDSYKNGYKLTLLQVLCGDPLSPTASIKLEHNGVEKEAMASGNGPVNATINAIQS 188 Query: 439 ITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNN 498 I ++EL ++++ A G D + +V+I G+ + G G +TDIV++SA A + +N Sbjct: 189 IVGADIELKEFTIQAVNGGSDDVSKVNIRIASEGKSYVGHGFSTDIVKASAYAYLDAMNK 248 Query: 499 IW 500 Sbjct: 249 FM 250 >UniRef50_B8J227 Pyruvate carboxyltransferase n=2 Tax=Desulfovibrio RepID=B8J227_DESDA Length = 611 Score = 241 bits (615), Expect = 5e-62, Method: Composition-based stats. Identities = 100/456 (21%), Positives = 189/456 (41%), Gaps = 35/456 (7%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDV--MEVG-FPVSSPGDFESV 58 ++Q+ I DTT RDG+QA +VK+ ++ L R+G + F + S D + + Sbjct: 49 AEQMRITDTTFRDGQQARP-PYTVKQVAKMFDFLHRLGGKTGLITASEFFLYSAKDRKCI 107 Query: 59 QTIARQV-KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + RV A R D+ +A + E + S HI KL T + Sbjct: 108 DVCRARGYRFPRVTAWIRATRDDLKLA----RDMEFDETGMLTSVSDYHIFLKLGKTRQQ 163 Query: 118 VIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLA-----RVVEAAINAGATT-INIPDT 171 ++ + M ++A + ED R I R++E + +G I + DT Sbjct: 164 AMDMYVGMAEQALEWGIIPRCHFEDITRADIYGFCLPLAQRLMELSRQSGMPVKIRLCDT 223 Query: 172 VGY-------TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 +GY +P I+ + + + H H+D + N + A G Sbjct: 224 MGYGVPYPGAALPRSVQRIVRAFTDEA-GVPGQWLEWHGHNDFHKVLVNGVTAWLNGCGA 282 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 V + G GER GN LE + + + A + + +Q + + IP N Sbjct: 283 VNSTLFGFGERTGNTPLEAL---LVEYISLTGDDAAADTTVLHEVAQFFEKELDYRIPHN 339 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEM 344 VG A S+G+H DG+ KN E Y I + + + + +T ++GRA V + ++ Sbjct: 340 YPFVGRDFNATSAGVHADGLAKNEEIYNIFDTKHLLGRSVPIIITDKTGRAGVAYWINTN 399 Query: 345 GYKESEYNLD-------NLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFS 397 E E + +YDA + + ++ G+ ++ + + + + PE F ++ + Sbjct: 400 LNLEKERQISKKHPAVGKIYDAIMAVYEETGRTTNFSHVEMEALVQ-RFMPELFVSEFDN 458 Query: 398 VQSGSNDI-ATAAVKLACGEEVKAEAANGNGPVDAV 432 ++ + ++ A V+LA +++ + +DA Sbjct: 459 MKQLAGELAANLLVRLARDKDLLDFGEKAHAKIDAF 494 >UniRef50_C7GH85 2-isopropylmalate synthase n=3 Tax=Roseburia RepID=C7GH85_9FIRM Length = 443 Score = 239 bits (610), Expect = 2e-61, Method: Composition-based stats. Identities = 89/368 (24%), Positives = 149/368 (40%), Gaps = 27/368 (7%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVD---VMEVGFPVSSPGDFES 57 M + + I DTT RDG+Q+ +A + ++ + I L R+G + + F + S D ++ Sbjct: 86 MPENIWITDTTFRDGQQS-RAPYTTEQIVTIYDYLHRLGGPKGLIRQSEFFLYSKKDRDA 144 Query: 58 VQTIARQV-KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 V + K V + R ++D + +K ++ S HI K++ T Sbjct: 145 VYKCLERGYKFPEVTSWIRASKQD----FQLVKDIGLRETGILVSCSDYHIFYKMKMTRR 200 Query: 117 EVIERAIYMVKRARNYTDDVEFSCEDAGRTPIA-----DLARVVEAAINAGATT-INIPD 170 EV+ + +++ ED R+ I +++ I D Sbjct: 201 EVMNLYLSVIRECLETGISPRCHLEDITRSDIYGFVIPFCVELMKLMDEYKIPIKIRACD 260 Query: 171 TVGYTM-------PFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGAR 223 T+GY + P GII GL + +I H H+D AV NS A GA Sbjct: 261 TMGYGVNFPGAVIPRSVPGIIYGLTTHA-GVPSELIEWHGHNDFYKAVNNSTTAWLYGAS 319 Query: 224 QVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 V ++ GIGER GN LE ++ K L+ ++ I ++ + P+ Sbjct: 320 GVNCSLFGIGERTGNTPLEAMVFEYAQLKGTLD---GMDTTVITELAEYFEKELGYVQPS 376 Query: 284 NKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDE 343 VGS +GIH DG+LKN E Y I Q +++ + R+ +D+ Sbjct: 377 RTPFVGSNFNVTRAGIHADGLLKNEEIYNIFDTGKFF-KQTTISICFQHIRSCRNRSLDQ 435 Query: 344 MGYKESEY 351 + SE Sbjct: 436 LLLPSSER 443 >UniRef50_A5N6T4 2-isopropylmalate synthase-related protein n=2 Tax=Clostridium kluyveri RepID=A5N6T4_CLOK5 Length = 453 Score = 237 bits (606), Expect = 6e-61, Method: Composition-based stats. Identities = 87/390 (22%), Positives = 156/390 (40%), Gaps = 31/390 (7%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERM----GVDVMEVGFPVSSPGDFE 56 + + I DTT RDG+Q++ + +E ++I L + G+ + + F + + D + Sbjct: 42 LPDNIYITDTTFRDGQQSMP-PYTSREIVRIFDYLHELDNNSGI-IKQTEFFLYTKKDRK 99 Query: 57 SVQTIARQV-KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + + + + V + R ++D+ + +K ++ S HI KL+ T Sbjct: 100 AAEVCMERGYEFPEVTSWIRADKEDLKL----VKDMGIKETGMLMSCSDYHIFKKLKMTR 155 Query: 116 DEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIA-----DLARVVEAAINAGATT-INIP 169 E ++ + + + A N ED R + +++ + A I Sbjct: 156 KETMDMYLDLAREALNNGIRPRCHLEDITRADFYGFVVPFVNELMKMSKEANIPIKIRAC 215 Query: 170 DTVGYTMP-------FEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGA 222 DT+G +P GII GL + + I H H+D V NS A GA Sbjct: 216 DTLGLGVPYNGVEIPRSVQGIIHGLR-NICEVPSESIEWHGHNDFYGVVTNSSTAWLYGA 274 Query: 223 RQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIP 282 + + GIGER GNC LE +I K + I +Q + +P Sbjct: 275 SSINTSFLGIGERTGNCPLEAMIFEYAQIKGNTK---NMKLHVITELAQYFEKEIKYSVP 331 Query: 283 ANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMD 342 VG+ +GIH DG+LK+ E Y I + I + + ++ SGRA + ++ Sbjct: 332 VRTPFVGTDFNVTRAGIHADGILKDEEIYNIFDTDKILGRPVVVAVSQYSGRAGIAAWVN 391 Query: 343 EMGYKESEYNL---DNLYDAFLKLADKKGQ 369 + E + D+ D D++ + Sbjct: 392 TYYRLKDEDKVNKNDSRIDQIKMWVDEQYR 421 >UniRef50_Q2LTE1 Isopropylmalate/homocitrate/citramalate synthases n=43 Tax=Bacteria RepID=Q2LTE1_SYNAS Length = 634 Score = 237 bits (605), Expect = 7e-61, Method: Composition-based stats. Identities = 89/445 (20%), Positives = 170/445 (38%), Gaps = 33/445 (7%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVD---VMEVGFPVSSPGDFESV 58 ++++ I DTT RDG+QA + ++ + + + R+G + + F + S D E+V Sbjct: 61 AEEIFITDTTFRDGQQARP-PYTTQQIVDLYQMMSRLGGYNGIIRQTEFFLYSNRDKEAV 119 Query: 59 QTIARQVK-NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + R +DI +K A + S HI KL T + Sbjct: 120 RMCQDLGLQYPEITGWIRAAREDI----PLVKEAGLKETGILTSVSDYHIFLKLNMTRSQ 175 Query: 118 VIERAIYMVKRARNYTDDVEFSCEDAGRTPIA-----DLARVVEAAINAGATT-INIPDT 171 +E + +VK + ED R I +++ +G I + DT Sbjct: 176 ALEEYLGIVKAILDAGIVPRCHFEDITRADIYGFCIPFAIELMKLREESGVDIKIRLCDT 235 Query: 172 VGYT-------MPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 +GY +P ++ + ++ ++ H H+D A+ N+ A G Sbjct: 236 MGYGVTYPGASLPRGVDKLVRAFIDDA-DVPGRLLEWHGHNDFHKALINATTAWLYGCSA 294 Query: 225 VEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 + G+GER GN +E +I+ ++ I+ I + IP+N Sbjct: 295 ANSTLLGLGERTGNPPIEGLII---EYIGLMGKTNGIDTTVITDIANYFKNEIEYKIPSN 351 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEM 344 VG+ +G+H DG++K+ E Y I I I +T +SG+A + + ++ Sbjct: 352 YPFVGADFNVTRAGVHADGLIKSEEIYNIFNTTKILKRPIVPMITDKSGKAGIAYWINSH 411 Query: 345 GYKESEYNLDNLYDAFLKLAD------KKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSV 398 + +D + K+ + G+V E L ++ PE F D + Sbjct: 412 FGLSGDSTVDKRHPGISKINKWIADEYELGRVTTISTEELEAKVRK-YMPELFMSDLERI 470 Query: 399 QSGSNDIATAAVKLACGEEVKAEAA 423 + + + A A ++ + Sbjct: 471 KFKAAEAAIAVLRKIIDDPAMKTMQ 495 >UniRef50_B1I1Z4 Pyruvate carboxyltransferase n=1 Tax=Candidatus Desulforudis audaxviator MP104C RepID=B1I1Z4_DESAP Length = 301 Score = 236 bits (602), Expect = 2e-60, Method: Composition-based stats. Identities = 84/275 (30%), Positives = 126/275 (45%), Gaps = 9/275 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M QV + DTTLRDGEQ S +EK+ +A AL+R+GV+++E G P + ++V+ Sbjct: 1 MP-QVFLVDTTLRDGEQTPGLVFSTEEKVAVASALDRLGVELIEAGIPAMGVDEQKAVRA 59 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 + +RV A R DI E+ A + S +H+ KL T ++ Sbjct: 60 VLGAGLRARVLAWNRAHPSDI----EASLACGATCLQISFPVSDIHLQHKLGRTRSWLLA 115 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 R ++ A +V EDA R A L + A AGA + DTVG PF Sbjct: 116 RLEEVMALAVAPGREVAVGAEDASRADPAFLRLFAKKAEEAGACRLRYCDTVGVLDPFRS 175 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 +S L ++ + H H+D G+A N+LAAV GA ++ +NG+GERAGN S Sbjct: 176 RDAVSDLTHKL----NIPLEFHAHNDFGMATANTLAAVKGGAAYLDVTVNGLGERAGNAS 231 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQ 275 L V ++ + V + V + Sbjct: 232 LSAVARGLRQFYGMEVVREETELAMLEGWVNSVRK 266 >UniRef50_Q1NS12 Pyruvate carboxyltransferase n=2 Tax=delta proteobacterium MLMS-1 RepID=Q1NS12_9DELT Length = 363 Score = 236 bits (601), Expect = 2e-60, Method: Composition-based stats. Identities = 95/334 (28%), Positives = 158/334 (47%), Gaps = 15/334 (4%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDF--ESVQTIARQ 64 + D+TLR+G Q + LS + ++++A L MG++ +EVG P+ D + + Q Sbjct: 4 LIDSTLREGLQTVGLDLSQERQVELAGELAAMGIEELEVG-PLRPDDDEVGQLLNRCRHQ 62 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 +R+ RC DI+ A + + I S + + KL+ V E Sbjct: 63 AGVARLAIWCRCRAADIERALAW----QPEVLALSIPISRLQMQVKLQRDEAAVKELVTA 118 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 ++R R + EDA R LA +V A GA I + DTVG P E + ++ Sbjct: 119 ALRRTRGRVGYLSLGLEDATRAEPRFLAEMVRLAKREGAHRIRLADTVGIATPAEISELV 178 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + + + I VHTH+D G+A N++AA+ AGA + + G+GERAG LEEV Sbjct: 179 RLVRDC--GGRRLAIGVHTHNDFGMAGANAIAALAAGADWADVTLLGLGERAGLARLEEV 236 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGV 304 + +R+ T + + ++ C PI + + +VGS FA +G+H + Sbjct: 237 AAYLALRRQRPYQLTG-----LPQLCARLAGFCGQPIASRQPVVGSDIFACETGLHLAAL 291 Query: 305 LKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVK 338 ++ YE P +G N+ QL +++GR A+ Sbjct: 292 QQDPATYEPFEPALVG-NRRQLLYGTKTGRQALA 324 >UniRef50_B4WHZ2 HMGL-like domain protein n=1 Tax=Synechococcus sp. PCC 7335 RepID=B4WHZ2_9SYNE Length = 411 Score = 235 bits (600), Expect = 3e-60, Method: Composition-based stats. Identities = 88/417 (21%), Positives = 157/417 (37%), Gaps = 47/417 (11%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIAR 63 ++I D TLRDGEQ + ++K +A + + GV + P + + V ++ Sbjct: 5 NLLISDETLRDGEQQVGLFF--EDKTTLANLIAQTGVQQI-ALMPAIHTSEAKLVSSLVD 61 Query: 64 QVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIAT-------------- 109 ++ A A E K ++ F A S + Sbjct: 62 SGLKRQIVASTMMRR----AAIEHAKTCGVRQVILFHAVSDRLLFLRDLEIAKDPRFKGK 117 Query: 110 ---------KLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAIN 160 ++ + ++ A+ V+ A + F+ EDA R L + Sbjct: 118 TIDDDIDLPVIQRSRQRMLIHALEHVRYAAEQGLRICFAAEDASRADNDFLVECINTLSP 177 Query: 161 AGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHA 220 + DTVG P A I L + +SVH H+D+GLA+ N++ AV A Sbjct: 178 Y-IDEFLLCDTVGSLTPKRTALWIQNLLQH---TRAVPLSVHFHNDMGLALENTIQAVCA 233 Query: 221 GARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMP 280 GAR + G GIGERAGN +E+V+ ++ R I++ + + + + P Sbjct: 234 GARGISGTFGGIGERAGNAPIEQVLKGLRSRFGWEV--AGIDYDALDQVVDYLHAQGHRP 291 Query: 281 IPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHR 340 + A H SGIH +L++R +Y I Q ++ SG + ++ Sbjct: 292 ---HAPYS-RQAQRHESGIHVSALLRDRRSYSIFPH-----QQPEIWFGKGSGSSNFQYL 342 Query: 341 MDE-MGYKESEYNLDNLYDAFLKLADKKGQVFD-YDLEALAFIGKQQEEPEHFRLDY 395 ++ + + + + L +A ++ + F D+ L LD Sbjct: 343 FEQYLNWPLPQCEYERLRAIVKAIAIREKRSFSVEDMLKLIQERNLIPLLNPLTLDS 399 >UniRef50_Q1DCT2 2-isopropylmalate synthase/homocitrate synthase family protein n=3 Tax=Myxococcales RepID=Q1DCT2_MYXXD Length = 421 Score = 234 bits (596), Expect = 8e-60, Method: Composition-based stats. Identities = 100/375 (26%), Positives = 166/375 (44%), Gaps = 21/375 (5%) Query: 5 VIIFDTTLRDGEQALQA-SLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFES----VQ 59 V I D TLRDG QA S +V+EK + ++ +GV + +G P + P E + Sbjct: 30 VEINDETLRDGMQATAVTSPTVEEKRGLLELMQHIGVSAVSLGMPAAGPWALEEVVTLAR 89 Query: 60 TIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRI-HTFIATSPMHIATKLRSTLDEV 118 I + AR + DI E+++ A + HTFI +SP+ + LD + Sbjct: 90 HIREEALRLEPNCAARTLHSDIVPIVEAVQRAGQPIVVHTFIGSSPLRQCAEA-WDLDFI 148 Query: 119 IERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 + + + A +V F ED R+ L + AA+ GA+ + + DTVG+ P Sbjct: 149 LRSSTAAIDFAVRQGLEVAFITEDTTRSTPETLELLFRAAVEHGASRLVLCDTVGHATPA 208 Query: 179 EFAGIISGLYERVPNIDK-AIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 ++ + V + + H H+D GLA+ N+L A+ AGA +V G GIGER G Sbjct: 209 GTRALVRWTRDLVERLGSPVKVEWHGHNDRGLALINALVALEAGATRVHGCGLGIGERTG 268 Query: 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 N +E + L + + ++Q+C +PIP N +VG AF ++ Sbjct: 269 NAPVEL-----LLLNLKLLGWIDQDLTRLVDYVLTLAQVCRVPIPRNYPLVGEDAFRTAT 323 Query: 298 GIHQDGVLKNRENYEIMTPESI--------GLNQIQLNLTSRSGRAAVKHRMDEMGYKES 349 G+H ++K E + + I + QL L SG + V++ + G +E+ Sbjct: 324 GVHSAAIIKALERGDDWLADHIYSSVPAGEFGRRQQLELGPMSGMSGVRYWLMVRGLQEN 383 Query: 350 EYNLDNLYDAFLKLA 364 E + + A Sbjct: 384 EQLCEEILRRAKSAA 398 >UniRef50_C7IGD9 Homocitrate synthase n=1 Tax=Clostridium papyrosolvens DSM 2782 RepID=C7IGD9_9CLOT Length = 274 Score = 230 bits (586), Expect = 1e-58, Method: Composition-based stats. Identities = 78/260 (30%), Positives = 120/260 (46%), Gaps = 8/260 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M ++ I DTTLRDGEQ + S +K+++A ++ G+ +E G P + E++ Sbjct: 1 MKEKKYIIDTTLRDGEQTPGYAFSKAQKVELAKVMDDAGIYQIEAGIPAMGNYEKETISE 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I Q KN+ + R DI+ + + IH S +HI +KL + Sbjct: 61 IMSQRKNALISTWNRMSRDDINNSFD----CHPDIIHITAPISYIHIYSKLNKNKKWLRN 116 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 V A++ +V EDA R I + + + G ++ DTVG P Sbjct: 117 TLQECVFMAKDKGYEVTVGFEDASRADITFIISMANLLADMGVKSVRFADTVGVLTPART 176 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 I + E V + +H H+DLG+A+ NSL A AGA ++ + GIGERAGNC Sbjct: 177 YQCIREIKENV----DIPVGIHAHNDLGMALANSLIAAKAGALYIDTTIGGIGERAGNCD 232 Query: 241 LEEVIMAIKVRKDILNVHTA 260 L + I+A +I HT Sbjct: 233 LYQFILAAGGIFNIKPEHTD 252 >UniRef50_C1MYB9 2-isopropylmalate synthase n=1 Tax=Micromonas pusilla CCMP1545 RepID=C1MYB9_9CHLO Length = 757 Score = 230 bits (586), Expect = 1e-58, Method: Composition-based stats. Identities = 99/403 (24%), Positives = 167/403 (41%), Gaps = 21/403 (5%) Query: 19 LQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI-------ARQVKNSRVC 71 + SL+ +KL++A L +GV +E G+P S+P D E A + + +++C Sbjct: 149 VGISLTCDDKLEVASHLVSLGVSHIEGGYPGSNPKDVEFFNRWDSSGLAKAAEARGTKLC 208 Query: 72 ALARCVEKDI----DVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVK 127 A K + D +L A L + +E + V Sbjct: 209 AFGMTRRKGVEAKDDEGLNALVRCVAPCACIVAKAWDEQCERVLGVSGEENLAMITDSVS 268 Query: 128 RARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 +V CE D R AA AGAT + + DT G T+P+ Sbjct: 269 YLVERGKEVLVDCEHFYDGHAANGEFAMRCAVAAAEAGATHVVLCDTNGGTLPWVVEEKT 328 Query: 185 SGLYERVPNI--DKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLE 242 + + + + VHTH+D LAV NSLA V GA V+G +NG GER GN + Sbjct: 329 RAVVDALKKSSNPSCRVGVHTHNDTALAVANSLAGVRGGASMVQGCVNGYGERTGNADVL 388 Query: 243 EVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQD 302 V ++++ + + + T+ V++ C P+ A + VGS AFAH G+H Sbjct: 389 VVAANLELKMGVTALPPGGVAKL-TATAAAVAKACKQPLEARQPYVGSSAFAHKGGLHVA 447 Query: 303 GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLK 362 + K +Y + P ++G N + ++ SGR V G + S+ + + Sbjct: 448 ALAKMPSSYNHVVPGTVG-NAARSVVSELSGRGNVLSAAVAAGREVSKDTAGIVLAQIKE 506 Query: 363 LADKKGQVFDYDLEALAFIGKQQE--EPEHFRLDYFSVQSGSN 403 L + KG V + ++ + ++ F + F+V + +N Sbjct: 507 L-ESKGFVLEDAGASVDILFQRAAAGYRAPFNVLEFNVSASNN 548 Score = 55.4 bits (132), Expect = 5e-06, Method: Composition-based stats. Identities = 20/92 (21%), Positives = 33/92 (35%), Gaps = 10/92 (10%) Query: 417 EVKAEAANGNGPVDAVYQAINRITEYN------VELVKYSLTAKGHGKDALGQVDIVA-- 468 K A GNGPV+A+ A+ + LV Y + + + Sbjct: 637 RTKLCVAEGNGPVNALANALQLALNERFPQLKRIHLVDYQVDLLSSEGTSAAVTRVTMDF 696 Query: 469 --NYNGRRFHGVGLATDIVESSAKAMVHVLNN 498 G + VG I+E+S +A+V + Sbjct: 697 VDRGGGGTWRTVGAHASIIEASFRALVDGMEY 728 >UniRef50_Q72WS3 Homocitrate synthase n=2 Tax=Desulfovibrio vulgaris RepID=Q72WS3_DESVH Length = 384 Score = 229 bits (585), Expect = 2e-58, Method: Composition-based stats. Identities = 99/375 (26%), Positives = 159/375 (42%), Gaps = 18/375 (4%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 + + V++ D+TLR+G QA ++ I + GV E G+ + D + Sbjct: 18 LRRCVMLIDSTLREGAQAYGVYFDAADRESILQGVAASGVTEAEAGW--AGQDDLAATLR 75 Query: 61 I-ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + AR + R+ RC D+D AAE A A R+H + +S H+ +L DEV+ Sbjct: 76 LGARVAPSLRLAVWCRCCTADLDKAAE----AGARRVHIGVPSSDAHMRLRLGMGRDEVL 131 Query: 120 ERAIYMVKRARNYTD-DVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 +R +++ A + V EDAGR L + A GA + DTVG P Sbjct: 132 QRVTTVLEHAAHLGFLHVTLGLEDAGRAAPDLLEALARTAARTGAHRLRCSDTVGLLTPD 191 Query: 179 EFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGN 238 ++ ++VH H+DLGLA N+LAA+ AGA + ++ G+GERAG Sbjct: 192 GMVRLVLLARRA----SALPVAVHCHNDLGLATANALAALDAGADGADVSLLGLGERAGI 247 Query: 239 CSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSG 298 EE+ A+ V + + + ++ M +P + A+ G FA SG Sbjct: 248 TRAEELAAALVVLRGES-----YRLDMLRGVCRRLAASLEMRLPPHWAVAGENLFAVESG 302 Query: 299 IHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYD 358 +H GV ++ +E P +G + +L + + G A V G L Sbjct: 303 VHLHGVQRDPALFEPFPPALVGAER-RLGVGGKCGSAGVAAMAHSHGLTLQGDALRRHVR 361 Query: 359 AFLKLADKKGQVFDY 373 A A G+ Sbjct: 362 AVRDKACSLGRPLTD 376 >UniRef50_B4B8D2 Pyruvate carboxyltransferase n=1 Tax=Cyanothece sp. PCC 7822 RepID=B4B8D2_9CHRO Length = 277 Score = 227 bits (580), Expect = 6e-58, Method: Composition-based stats. Identities = 116/277 (41%), Positives = 170/277 (61%), Gaps = 6/277 (2%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 +S+Q++I DTT+RDGE +S EKL++A LE VD++EV +P S DF+ + Sbjct: 4 LSEQILILDTTMRDGELVPGIKMSQAEKLRLAQLLEEAKVDIIEVSYPAKSQQDFDEIVA 63 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 ++R++KNS VCAL+ ++I+ AA LK A RIH + S +++A K E + Sbjct: 64 VSREIKNSIVCALSNLSVQEIERAATGLKSASRGRIHLY---SNVNLAKKEPLKRQEALS 120 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 V ARNY DD+E+S DA R+ + L R +E AIN+GA TINIPD++G +P EF Sbjct: 121 MIQQGVTLARNYCDDIEWSAFDASRSDLDFLCRGIEMAINSGAKTINIPDSLGVLLPAEF 180 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 A ++ ++ RVPNIDK+I+SVH HDD A+ NSL A+ G RQ+E ++NG+G R GN + Sbjct: 181 AQLLEKIFTRVPNIDKSIVSVHCHDDCEQALLNSLIALEVGVRQIECSLNGLGARKGNAN 240 Query: 241 LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQIC 277 L+ VI K T++ ++I +LV QI Sbjct: 241 LKSVI---KEIDQNPTYKTSVILEKIPPAEELVKQIS 274 >UniRef50_A8MBK1 Pyruvate carboxyltransferase n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8MBK1_CALMQ Length = 419 Score = 226 bits (576), Expect = 2e-57, Method: Composition-based stats. Identities = 92/397 (23%), Positives = 167/397 (42%), Gaps = 30/397 (7%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEK--LQIALALERMGVDVMEVGFPVSSPGDFESVQ 59 ++ I DTT RDG+QA A K ++ L+ + F + + D V Sbjct: 17 PSELYITDTTFRDGQQAFYAYSPSDVKGLFKLLSELDNGSGRLSRSEFFLYTERDRRIVN 76 Query: 60 TIARQV-KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEV 118 + K +V R +D+ + ES + ++ S +HI K +T V Sbjct: 77 AVKGLGLKYPKVIGWGRARVEDVRLVKES----GLDEMVMLMSISDIHIKAKFNTTRARV 132 Query: 119 IERAIYMVKRARNYTDDVEFSCEDAGRTPI-----ADLARVVEAAINAGAT-TINIPDTV 172 +E+ + + A + S ED R + + +++ GA+ I +PDT Sbjct: 133 VEKYLEAAEEAMRSGIALRCSLEDVTRADVLGFVVPFVNKLLRLRDKYGASLVIKLPDTT 192 Query: 173 GYTMPFEFAGI------ISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVE 226 G +P+ A + + + + I + H H D +AV N++AA GA Sbjct: 193 GVGVPYPTASLPYSIPKLIWVMRSLLKIPSNALEFHGHGDYHMAVANAVAAWVYGAGINN 252 Query: 227 GAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQI--CNMPIPAN 284 G + GIGERAGN +E +++ K + S++V +P + Sbjct: 253 GTLLGIGERAGNVPIEALVVWYSRLKGSFDGMEP------RVISRIVEYFKGMGYSVPRH 306 Query: 285 KAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEM 344 + IVGS A+A ++GIH D K+ E Y M P +G+ + + + +GR+ + H + + Sbjct: 307 QPIVGSNAYATAAGIHIDAQSKDPETYLSMDPSLVGMRET-ILIGPYTGRSGIAHVLKGI 365 Query: 345 GYK--ESEYNLDNLYDAFLKLADKKGQVFDYDLEALA 379 G +++ ++ +Y A ++L D+ E Sbjct: 366 GVNAGKNDETVERVYRAVVRLYDEGRLREPMSEEEFI 402 >UniRef50_P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial n=241 Tax=cellular organisms RepID=HMGCL_HUMAN Length = 325 Score = 225 bits (573), Expect = 4e-57, Method: Composition-based stats. Identities = 66/296 (22%), Positives = 125/296 (42%), Gaps = 29/296 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP-----GDF 55 + ++V I + RDG Q + +S K+++ L G+ V+E VS GD Sbjct: 29 LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDH 88 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 V ++ L ++ E+ A A + F A S + + ++ Sbjct: 89 TEVLKGIQKFPGINYPVLTPNLK-----GFEAAVAAGAKEVVIFGAASELFTKKNINCSI 143 Query: 116 DEVIERAIYMVKRARNYTDDV------EFSCEDAGRTPIADLARVVEAAINAGATTINIP 169 +E +R ++K A++ V C G+ A +A V + + G I++ Sbjct: 144 EESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLG 203 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G P ++S + + VP A ++VH HD G A+ N+L A+ G V+ ++ Sbjct: 204 DTIGVGTPGIMKDMLSAVMQEVP---LAALAVHCHDTYGQALANTLMALQMGVSVVDSSV 260 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNM 279 G+G +GN + E+++ ++ +HT +N Q++ + Q N Sbjct: 261 AGLGGCPYAQGASGNLATEDLVYMLEGLG----IHTGVNLQKLLEAGNFICQALNR 312 >UniRef50_UPI0001B425AC 2-isopropylmalate synthase n=1 Tax=Listeria monocytogenes FSL J1-208 RepID=UPI0001B425AC Length = 258 Score = 225 bits (573), Expect = 4e-57, Method: Composition-based stats. Identities = 92/240 (38%), Positives = 143/240 (59%), Gaps = 3/240 (1%) Query: 258 HTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPE 317 T I + +S L+S++ MP+P NKA++G A+AH SGIHQDGVLKN + YEI+TP Sbjct: 3 ETNIVLNQFKNSSDLISRLSGMPVPRNKAVIGGNAYAHESGIHQDGVLKNPDTYEIITPA 62 Query: 318 SIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEA 377 +G+++ L L SG+ A RM+E+GY SE L + + F +LAD K +V + DL A Sbjct: 63 LVGVDKNSLPLGKLSGKHAFLTRMEEIGYTLSEKELKDAFKRFKQLADAKKEVTEDDLHA 122 Query: 378 LAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKL-ACGEEVKAEAANGNGPVDAVYQAI 436 L +G+ E + F L + VQ + + A V++ + +AA G+G ++A+Y I Sbjct: 123 LI-LGQSSESADDFELKHLQVQYVTGGVQGAIVRIEERNGALIEDAATGSGSIEAIYNTI 181 Query: 437 NRITEYNVELVKYSLTAKGHGKDALGQVDIVANY-NGRRFHGVGLATDIVESSAKAMVHV 495 NR+ + ++EL Y + A G+DA +V +V NG FHG+G+ D++ +SAKA + Sbjct: 182 NRLMKQDIELTDYRIQAITAGQDAQAEVHVVIKDNNGTEFHGIGIDFDVLTASAKAYLQA 241 >UniRef50_B1QUV5 Homocitrate synthase 1 n=2 Tax=Clostridium butyricum RepID=B1QUV5_CLOBU Length = 265 Score = 222 bits (567), Expect = 2e-56, Method: Composition-based stats. Identities = 71/245 (28%), Positives = 112/245 (45%), Gaps = 8/245 (3%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60 M + V I DTTLRDGEQ+ + ++++KL+IA L+ G+ +E G P + E ++ Sbjct: 1 MKRNVNIVDTTLRDGEQSAGKAFTMEQKLKIAKYLDNNGIYQIECGIPAMGCMEQEIIKA 60 Query: 61 IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE 120 I KN+ + R DI + + IH + S + I L + E Sbjct: 61 IKANTKNALISTWNRLNIDDIKAS----MNCKPHIIHISVPVSDLQIYENLNKDKKWIEE 116 Query: 121 RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF 180 I + + DV EDA R I + + G I DTVG + Sbjct: 117 NLIKCIYYTKEQGYDVTVGLEDASRADIKYIIELSSLIEKLGVNRIRYSDTVGILSLLKT 176 Query: 181 AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS 240 +++ + + +H H+D G+A+G S+ AV GA V+ ++GIGER GNCS Sbjct: 177 KNVVNEIRRN----SNLKVEIHAHNDFGMALGISVEAVKNGAEFVDCTLDGIGERTGNCS 232 Query: 241 LEEVI 245 L+E + Sbjct: 233 LQEFL 237 >UniRef50_B2J8P8 Pyruvate carboxyltransferase n=2 Tax=Nostocaceae RepID=B2J8P8_NOSP7 Length = 392 Score = 222 bits (567), Expect = 2e-56, Method: Composition-based stats. Identities = 93/394 (23%), Positives = 160/394 (40%), Gaps = 45/394 (11%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 +II D TLRDGEQ S K ++A + + GVD + + P + E V+++ + Sbjct: 6 IIISDETLRDGEQQAGIFFSYPTKQKLAHLIAQTGVDRLSM-MPRVHEQEEELVKSLVSE 64 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHI----------------- 107 +S + A ++ ID A K+ RI F S + Sbjct: 65 GLDSLIAAATMTGKQYIDQA----KMYGVKRIILFYGLSDRLLFLRDPQIRLLNEFKGKT 120 Query: 108 ------ATKLRSTLDEVIERAIYMVKRARN-YTDDVEFSCEDAGRTPIADLARVVEAAIN 160 + I+ + + A V+F+ EDA R L + + + Sbjct: 121 IDDDIPKKVIERIRQNAIDLIVENLHYATTVAGLTVDFAAEDASRADFDFLVQCIRSFSP 180 Query: 161 AGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHA 220 + DTVG P + I+ L +R VH H+D+GLA+ N+L +V A Sbjct: 181 Y-LDHFMLCDTVGVLTPEKSYIWINDLLQR---TTGVAFGVHYHNDMGLALENTLQSVIA 236 Query: 221 GARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMP 280 GA V G GIGERAGN ++E+V+ ++VR I IN+ I + + Q+ P Sbjct: 237 GATLVSGTFCGIGERAGNVAIEQVLNGLRVRFGIEVK--GINYDAIAAVTDYIEQLGIRP 294 Query: 281 IPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHR 340 P A H SGIH + + + ++Y + +I ++ SG + ++ Sbjct: 295 APP----YSQTAQRHESGIHVNSLFSDPQSYAALPYNTI-----EVLFGKWSGISNFQYL 345 Query: 341 MD-EMGYKESEYNLDNLYDAFLKLADKKGQVFDY 373 + ++ + + + LA ++ + F Sbjct: 346 FEKQLQNPQPRNQYEKMRSVIKSLAVEQERYFTA 379 >UniRef50_D0LGL9 2-isopropylmalate synthase n=3 Tax=Nannocystineae RepID=D0LGL9_HALO1 Length = 424 Score = 222 bits (565), Expect = 4e-56, Method: Composition-based stats. Identities = 84/402 (20%), Positives = 166/402 (41%), Gaps = 25/402 (6%) Query: 3 QQVIIFDTTLRDGEQALQA-SLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTI 61 +QV TLRDG Q+ + +KL++ + +G+ +++G P + E TI Sbjct: 29 RQVSFLCETLRDGIQSPSVVDPDIGDKLRLVELADSLGIHHIDIGLPGAGNRAVEDCTTI 88 Query: 62 ARQVKNSRV----CALARCVEKDIDVAAESLKVAEAF-RIHTFIATSPMHIATKLRSTLD 116 A ++++++ AR + D+ + + + TFI +SP+ L+ Sbjct: 89 ATFIRDNKLRIRPACAARTHKNDVGAIVDISQAVGIEIEVLTFIGSSPI-RQYAESWDLE 147 Query: 117 EVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTM 176 ++ + + A + V F ED R+ L ++ AI GA + + DTVG++ Sbjct: 148 RMLNFSSEAIDLAARHNLPVTFVTEDTTRSRPEVLDQMFRNAIEHGANRLCLCDTVGHST 207 Query: 177 PFEFAGIISGLYERVP--NIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 P +I + I H H+D GL V N++ A+ GA +V G G+GE Sbjct: 208 PDGIHNLIRFTRNLLEAMGRPDVGIDWHGHNDRGLGVVNTIFAIEYGASRVHGTAMGLGE 267 Query: 235 RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFA 294 R GN +L++V + +L + ++ ++ ++ C++ IP + GS AF Sbjct: 268 RVGNAALDQV----LLNLKLLGELPEQDLSKLLLWCKVAAKACHVAIPPQYPLAGSDAFR 323 Query: 295 HSSGIHQDGVLKNRENYEIMT--------PESIGLNQIQLNLTSRSGRAAVKHRMDEMGY 346 ++G+H ++K + P + + ++ + SG + V + + + G+ Sbjct: 324 TATGVHAAAIIKAEKKGHEWLADRIYSGVPAGMFGREQEIEIGHYSGESNVIYWLRKRGF 383 Query: 347 KESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEP 388 + L L A + +V + Sbjct: 384 DPTPE----LVRTVLSAAKRGHRVLSTEEILQVIKEHNHASG 421 >UniRef50_Q2RAU5 Hydroxymethylglutaryl-CoA lyase, mitochondrial, putative, expressed n=8 Tax=cellular organisms RepID=Q2RAU5_ORYSJ Length = 387 Score = 221 bits (562), Expect = 6e-56, Method: Composition-based stats. Identities = 60/296 (20%), Positives = 117/296 (39%), Gaps = 29/296 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP-----GDF 55 + + V I + RDG Q ++++ K+++ L G+ V+E VS D Sbjct: 89 LPRFVKIVEVGPRDGLQNEKSTVPASVKIELIHKLVASGLSVVEATSFVSPKWVPQLADA 148 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + V R V + R L + E+ A A + F + S + L T+ Sbjct: 149 KDVLQGIRHVPDVRFPVLTPNL-----RGFEAALAAGAKEVAVFASASESFSKSNLNCTI 203 Query: 116 DEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIP 169 E + R +V A+ + + C G + +A V + + G + I++ Sbjct: 204 KESLVRYRDVVTSAKKHGMRIRGYVSCVVGCPVEGTIHPSKVAYVAKELYDMGCSEISLG 263 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G P ++ + VP ++VH HD G A+ N L ++ G V+ ++ Sbjct: 264 DTIGVGTPGSILAMLEAVMSFVP---VDKLAVHFHDTYGQALANILVSLQLGINIVDSSV 320 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNM 279 +G+G GN + E+V+ + + T ++ ++ +S+ Sbjct: 321 SGLGGCPYAKGATGNVATEDVVYMLHGLG----IETNVDLNKLMDAGDYISKHLGR 372 >UniRef50_A6CMV0 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillus RepID=A6CMV0_9BACI Length = 311 Score = 220 bits (560), Expect = 1e-55, Method: Composition-based stats. Identities = 61/297 (20%), Positives = 121/297 (40%), Gaps = 27/297 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSS---PGDFES 57 + ++V + + RDG Q + + K+Q AL+ G+ ME+ VS P ++ Sbjct: 16 LPKKVTMIEVGPRDGLQNEKNFVPTDIKIQFIRALKEAGLKEMELTSFVSPKWVPQMKDA 75 Query: 58 VQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + + + + R LA K +D E+ A + F+ S + T E Sbjct: 76 SEIVESCLNSERDIVLAPN-RKGVDRVLETKGKA----VAVFVGVSNSFNKKNINKTTAE 130 Query: 118 VIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIPDT 171 +E +V + V F C G+ P + ++ ++ G +++ DT Sbjct: 131 SLEELKPIVGELKEKGYFVRACISTSFYCPYEGKIPPQETLQLCREFVDMGVDELSVADT 190 Query: 172 VGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNG 231 +G P E + S L + +P +++ H HD +A+ N LA++ AG + + + G Sbjct: 191 IGMANPKESFELFSLLKKTLPE---VLMTAHFHDTRKMALANILASLQAGVDRFDTSAGG 247 Query: 232 IG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIP 282 +G +GN + E+V+ + + T ++ + LV+ + I Sbjct: 248 LGGCPFAPGASGNAATEDVVFMLHQMG----IETGVDLDSLTAAVNLVAPHLSRTID 300 >UniRef50_A0YSY8 2-isopropylmalate synthase n=1 Tax=Lyngbya sp. PCC 8106 RepID=A0YSY8_9CYAN Length = 271 Score = 219 bits (559), Expect = 2e-55, Method: Composition-based stats. Identities = 97/269 (36%), Positives = 156/269 (57%), Gaps = 5/269 (1%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 ++IFDTTLRDGE S +K+QIA LE +GVD +E+G+P D + + +++ Sbjct: 7 ILIFDTTLRDGELTPGVHFSTPDKVQIAQQLEEIGVDTIEIGYPGRYAKDIDEIIAVSQV 66 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 +K S +CALA E +I+ AA+SL+ AE I+ + + + L ++ Sbjct: 67 IKGSTLCALAGSQETEINKAAKSLEKAEKSSINIYTLVNLTSSSKTLDKN--SILSTLKK 124 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 + +A+NY + V+++ DA R I L V+ AI +GA I+IPD++G +P +F ++ Sbjct: 125 QISQAKNYCNIVQWTAFDATRGDINFLCEAVQTAIESGAKIISIPDSLGVALPEDFYNLL 184 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 LY+ +P + +SVH H+DLG AV NSL + G RQ+E A+NG+G R GN +L +V Sbjct: 185 QKLYQNIPQLQHVTVSVHCHNDLGKAVENSLVGLEVGVRQIECAVNGLGARKGNANLTKV 244 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLV 273 + I+ + +T INH I + S+L+ Sbjct: 245 VNLIQSH---HSYYTTINHNLIPKISELI 270 >UniRef50_C7YY11 Putative uncharacterized protein n=2 Tax=Nectriaceae RepID=C7YY11_NECH7 Length = 398 Score = 219 bits (558), Expect = 2e-55, Method: Composition-based stats. Identities = 78/282 (27%), Positives = 137/282 (48%), Gaps = 9/282 (3%) Query: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 I DTTLR+GEQ A + K++IA AL+ GV+ +E+ P +S Q I + Sbjct: 122 IIDTTLREGEQFATAHFDTETKIKIAQALDEFGVEYLELTSPAASEQSKLDCQAICKLGL 181 Query: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 +++ RC D +A ++ I+ I TS + LD + ++A ++ Sbjct: 182 KAKILCHIRCNMDDARIAVQT----GVDGINMCIGTSAQLMKHSHGKDLDWIAKKATEVI 237 Query: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 + A+++ +V FS ED+ R+ +++ ++ GA + I DTVG E IS Sbjct: 238 QFAQSHGVEVRFSGEDSFRSDFSEIIKLYSLVDRLGAQRVGIADTVGGATWREVDEKIST 297 Query: 187 LYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIM 246 L + + I H H+D G AV N+ A+ AGA ++ + GIGER G SL ++ Sbjct: 298 LRQVI----SCDIETHFHNDTGCAVSNAFTALEAGATHIDTTVLGIGERNGITSLGGLMA 353 Query: 247 AIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIV 288 ++ + +V +++ +LV++ ++ IP N +V Sbjct: 354 SLMYSEHK-SVLNKYKLEKLAALEELVAKAVDVEIPWNNFVV 394 >UniRef50_B0SA13 2-isopropylmalate synthase n=5 Tax=Leptospira RepID=B0SA13_LEPBA Length = 299 Score = 218 bits (556), Expect = 4e-55, Method: Composition-based stats. Identities = 65/309 (21%), Positives = 121/309 (39%), Gaps = 31/309 (10%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSS---PGDFESVQ 59 ++V I + RDG Q + LS ++K + L G +E+ V P ++++ Sbjct: 2 EKVKITEVGPRDGLQNEKTILSTQDKFEFIKRLVESGAKHIELTSFVRKDRIPQMADAME 61 Query: 60 T----IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + K+ + L + E K+A + F ATS + T+ Sbjct: 62 LSALVLPLYAKDVQFSCLTPNTK-----GYEGAKLAGFNEVAVFTATSESFTKKNINMTV 116 Query: 116 DEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIP 169 E E + A+ V +C G+ P V E ++AGA I++ Sbjct: 117 KESFESFQPIFGLAKQDGIKVRGYISTVVACPYEGKIPPEKTLEVAERLLDAGAYEISLG 176 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 +T+G +P E ++S L +++P ++ H HD G+A+ N+ A+ G R + + Sbjct: 177 ETIGVAVPNEIESLLSVLLKKIPISY---LNCHFHDTYGMAIANTKQALSMGIRSFDSSA 233 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 G+G AGN + E+++ + T IN + + SQ + + + Sbjct: 234 GGLGGCPYAKGAAGNVATEDLVYFLSREG----YDTGINLDSLIQVSQFMEAKLDRSFNS 289 Query: 284 NKAIVGSGA 292 I Sbjct: 290 RTYIAKKNV 298 >UniRef50_A8WG57 Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2 n=47 Tax=root RepID=HMGC2_DANRE Length = 335 Score = 217 bits (553), Expect = 7e-55, Method: Composition-based stats. Identities = 58/296 (19%), Positives = 117/296 (39%), Gaps = 29/296 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP-----GDF 55 + V I + RDG Q + + + K+Q+ L + G+ V+E VSS D Sbjct: 39 LPVYVKIVEVGPRDGLQNEKEIVPTEVKIQLIDLLSQTGLPVIEATSFVSSKWVAQMADH 98 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 +V ++ + R L + ++ A A + F + S + ++ Sbjct: 99 TAVLKGIKRSPDVRYPVLTPNI-----QGFQAAVAAGANEVAVFGSASETFSRKNINCSI 153 Query: 116 DEVIERAIYMVKRARNYTDDV------EFSCEDAGRTPIADLARVVEAAINAGATTINIP 169 +E ++R +V A+ V C G+ + + +V + G +++ Sbjct: 154 EESLQRFEQVVSAAKQEGIPVRGYVSCALGCPYEGQVKPSQVTKVAKRLFELGCYEVSLG 213 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G A ++S + VP ++VH HD G A+ N L A+ G V+ ++ Sbjct: 214 DTIGVGTAGSMAEMLSDVLTEVPAG---ALAVHCHDTYGQALPNILIALQMGVSVVDASV 270 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNM 279 G+G +GN S E+++ + + T ++ ++ + + N Sbjct: 271 AGLGGCPFAKGASGNVSTEDLLYMLHGLG----IETGVDLLKVMEAGDFICKALNR 322 >UniRef50_Q8TB92 Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2 n=26 Tax=cellular organisms RepID=HMGC2_HUMAN Length = 370 Score = 217 bits (552), Expect = 1e-54, Method: Composition-based stats. Identities = 61/295 (20%), Positives = 113/295 (38%), Gaps = 29/295 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSS---PGDFES 57 + + V I + RDG Q + + K++ L + G+ V+EV VSS P + Sbjct: 74 LPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQMADH 133 Query: 58 VQTI--ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + + Q R L + A A I F A S + ++ Sbjct: 134 TEVMKGIHQYPGVRYPVLTPNL-----QGFHHAVAAGATEISVFGAASESFSKKNINCSI 188 Query: 116 DEVIERAIYMVKRARNYTD------DVEFSCEDAGRTPIADLARVVEAAINAGATTINIP 169 +E + + +VK AR+ C G + V + G I++ Sbjct: 189 EESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLG 248 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G P ++ + + +P ++VH HD G A+ N L A+ G V+ A+ Sbjct: 249 DTIGVGTPGSMKRMLESVMKEIP---PGALAVHCHDTYGQALANILTALQMGINVVDSAV 305 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICN 278 +G+G +GN + E++I + ++T +N ++ + + N Sbjct: 306 SGLGGCPYAKGASGNVATEDLIYMLNGLG----LNTGVNLYKVMEAGDFICKAVN 356 >UniRef50_C0GGI7 Pyruvate carboxyltransferase n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GGI7_9FIRM Length = 307 Score = 216 bits (549), Expect = 2e-54, Method: Composition-based stats. Identities = 65/302 (21%), Positives = 131/302 (43%), Gaps = 29/302 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSS---PGDFES 57 +S V+I + LRDG Q + ++ ++K+++A AL G+ +E+ VS P ++ Sbjct: 7 LSGDVLIREVGLRDGLQNEKQFVATEDKIRLARALTAAGLREIEITSFVSPKAVPQMRDA 66 Query: 58 VQTIARQ--VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + +A + AL AE + + ++ S H +R ++ Sbjct: 67 KEIVAALGQPEGVTYSALVVNR-----RGAEDAIASGVKELQYVVSCSETHSQKNVRMSV 121 Query: 116 DEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIP 169 DE +++A + A+ + F C G+T + ++E + G +++ Sbjct: 122 DEALQQAAIISDLAKENGLTIRTALSATFGCPFEGKTSYDRVYDLLEKLFSLGVERVSLS 181 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT G P + A + G+ R P S+H HD GL + +LA V AG R +E ++ Sbjct: 182 DTAGLGNPRQVAQLCQGIVARFPED---RFSLHLHDTRGLGLACTLAGVWAGIRVIESSI 238 Query: 230 NGIGE------RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 G+G GN + E+V+ ++ + T ++ Q++ + + +I + + Sbjct: 239 GGLGGCPFVPNATGNIATEDVVYMMEEMG----ISTGLDWQQLMNAAMMAEKILGRDLNS 294 Query: 284 NK 285 + Sbjct: 295 KQ 296 >UniRef50_P35915 Hydroxymethylglutaryl-CoA lyase n=108 Tax=cellular organisms RepID=HMGCL_CHICK Length = 298 Score = 215 bits (548), Expect = 3e-54, Method: Composition-based stats. Identities = 59/296 (19%), Positives = 120/296 (40%), Gaps = 29/296 (9%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSS---PGDFESV 58 Q+V + + RDG Q ++ + K+++ L G+ V+E VS P + Sbjct: 3 PQRVKVVEVGPRDGLQNEKSVVPTPVKIRLIDMLSETGLPVIEATSFVSPRWVPQMADHA 62 Query: 59 QTI--ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 + + ++ L ++ ++ A A + F A S + + +++ Sbjct: 63 EVMQGINKLPGVSYPVLTPNLK-----GFQAAVAAGAKEVSIFGAASELFTKKNINCSIE 117 Query: 117 EVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIPD 170 E +ER ++ AR + V C G A +A V + + G I++ D Sbjct: 118 ESLERFSEVMNAARAASIPVRGYVSCVLGCPYEGNISAAKVAEVSKKMYSMGCYEISLGD 177 Query: 171 TVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMN 230 +G P +++ + + VP ++VH HD G A+ N L A+ G V+ ++ Sbjct: 178 RIGIGTPGSMKEMLAAVMKEVP---VGALAVHCHDTYGQALANILVALQMGVSVVDASVA 234 Query: 231 GIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMP 280 G+G +GN + E+++ + +HT ++ Q++ T + N Sbjct: 235 GLGGCPYAQGASGNVATEDLVYMLNGLG----IHTGVDLQKLMDTGTFICNALNRR 286 >UniRef50_O34873 Hydroxymethylglutaryl-CoA lyase yngG n=13 Tax=Bacteria RepID=HMGCL_BACSU Length = 299 Score = 214 bits (546), Expect = 5e-54, Method: Composition-based stats. Identities = 56/300 (18%), Positives = 114/300 (38%), Gaps = 29/300 (9%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPG-----DFE 56 ++V I + RDG Q ++ ++K+ L R G+ +E+ V D Sbjct: 4 PKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSYIEITSFVHPKWIPALRDAI 63 Query: 57 SVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 V + K AL E+ F++ S H + + Sbjct: 64 DVAKGIDREKGVTYAALVPN-----QRGLENALEGGINEACVFMSASETHNRKNINKSTS 118 Query: 117 EVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIPD 170 E + + A+ F C PI + R+ EA G + +++ D Sbjct: 119 ESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVIRLSEALFEFGISELSLGD 178 Query: 171 TVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMN 230 T+G P + ++ L R P I++H HD G A+ N + A+ G +G+ Sbjct: 179 TIGAANPAQVETVLEALLARFPA---NQIALHFHDTRGTALANMVTALQMGITVFDGSAG 235 Query: 231 GIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 G+G +GN + E+++ ++ +++ T + +++ ++ + + P+P+ Sbjct: 236 GLGGCPYAPGSSGNAATEDIVYMLEQ----MDIKTNVKLEKLLSAAKWIEEKMGKPLPSR 291 >UniRef50_Q97A78 2-isopropylmalate/homocitrate synthetase n=1 Tax=Thermoplasma volcanium RepID=Q97A78_THEVO Length = 344 Score = 214 bits (545), Expect = 7e-54, Method: Composition-based stats. Identities = 77/380 (20%), Positives = 152/380 (40%), Gaps = 45/380 (11%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 ++ D TLR+G QA + ++ EK++IA ++ + G+ V +P + + E+ + I Sbjct: 1 MLTDDTLREGMQAPGIAFTLDEKIRIAQSISKSGIKRALVSYPSAHESEVEAARKITDLH 60 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 +L R +++D+D + + + I + + Sbjct: 61 LFDDTYSLGRSIKEDVDSIISTGSK-----VTLHLPFGDY------------DINKICDV 103 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 VK A +++D VE + D + + + + GA+ + IPDT G P ++S Sbjct: 104 VKYASDHSDSVEIAIVDMVKYEKEKIFDLAKKLWECGASIVQIPDTTGRATPKRVHDVVS 163 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245 + + + K + VH H+D GLA+ NS+A + AG V+ + GIGER G + Sbjct: 164 YIKQNL----KVKVEVHCHNDHGLAIANSIAGIEAGCDYVDTTIFGIGERNGIADTASIA 219 Query: 246 MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMP-----IPANKAIVGSGAFAHSSGIH 300 ++ IN + + +T L+S++ N I G + ++G H Sbjct: 220 SYLEKAG----YEDKINFEMLRKTYDLMSELILRKAGYRFFADNMPIFGRNVLSITAGTH 275 Query: 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF 360 ++ +++L +G V + + G + E + L Sbjct: 276 --------STSKVFP-------NSRVSLNVYAGSRLVASILRKNGIEPDERKVKLLVSKI 320 Query: 361 LKLADKKGQVFDYDLEALAF 380 L+ +G+V D + Sbjct: 321 KDLSSNEGRVVGEDEVLKIY 340 >UniRef50_C5T2M7 Pyruvate carboxyltransferase n=1 Tax=Acidovorax delafieldii 2AN RepID=C5T2M7_ACIDE Length = 358 Score = 214 bits (544), Expect = 1e-53, Method: Composition-based stats. Identities = 58/303 (19%), Positives = 110/303 (36%), Gaps = 29/303 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVG---FPVSSPGDFES 57 + +V + D RDG Q ++ + + K+ + L+ G+ +EV P P ++ Sbjct: 59 IPSRVKLIDVGPRDGLQNEKSPVPAEVKIGLVHRLQDAGLKNIEVTSYVSPKWVPQMADN 118 Query: 58 VQTI--ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + + + L ++ E+ + I F + S + ++ Sbjct: 119 HEVMSGIARQSGVVYSVLTPNLK-----GFEAAVLDRPDEIVVFGSASEAFSQKNINCSI 173 Query: 116 DEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIP 169 E IER +V+ AR V C G +A + G I + Sbjct: 174 AESIERFAPVVEAARAAGIHVRGAMSCTVGCPYEGEIAPERVAYLAGLMKQIGVQHIGVA 233 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G P + + + D IS H HD G A+ N+LA + G Q + ++ Sbjct: 234 DTIGVGTPRKVQRAVEATLQHY---DLNDISGHFHDTYGQALANTLATLEMGVWQYDTSV 290 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 G+G GN + E+V+ + + + T I+ ++ +S + Sbjct: 291 AGLGGCPYAKGATGNVATEDVVYMLH----GMGIETGIDLDKLIDAGAYISGFLGRKPNS 346 Query: 284 NKA 286 A Sbjct: 347 RAA 349 >UniRef50_UPI00015B4E2A PREDICTED: similar to hydroxymethylglutaryl-coa lyase n=1 Tax=Nasonia vitripennis RepID=UPI00015B4E2A Length = 327 Score = 213 bits (542), Expect = 1e-53, Method: Composition-based stats. Identities = 59/307 (19%), Positives = 114/307 (37%), Gaps = 30/307 (9%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSS---PGDFESVQTI 61 V I + RDG Q ++ L + K+++ L + G+ +EV VS P +S + Sbjct: 27 VRIVEVGPRDGLQNIRKVLPTETKIELINRLSQTGLRSVEVTSFVSPKWVPQMADSAEVY 86 Query: 62 --ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + N L ++ + + F A S + ++ E + Sbjct: 87 QGVEKNPNVEYSVLVPNLK-----GLDKALKLGVKEVVLFTAASETFNQKNINCSIAESL 141 Query: 120 ERAIYMVKRARN------YTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVG 173 + + K + C G ++A V EA ++ G + + DT+G Sbjct: 142 KNCKEITKICKEKKIKARAVISCIAGCPYEGEIKPVNVANVAEALLDMGCYEVGLGDTIG 201 Query: 174 YTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIG 233 P + A + L ++ D +VH HD G A+ N + G R + ++ G+G Sbjct: 202 VATPKKMAHLFEELK-KMTGGDVWRFAVHCHDTYGQAIANIYECLRQGIRVFDSSVAGLG 260 Query: 234 ------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAI 287 +GN S E+++ + T ++ ++ + Q +S+ N + Sbjct: 261 GCPYAPGASGNVSTEDLVYLLHGEG----FETGVDLDKLIQVGQFISEQI---PSTNHSK 313 Query: 288 VGSGAFA 294 GS A Sbjct: 314 AGSAVLA 320 >UniRef50_C8QZK2 2-isopropylmalate synthase n=1 Tax=Desulfurivibrio alkaliphilus AHT2 RepID=C8QZK2_9DELT Length = 399 Score = 213 bits (542), Expect = 1e-53, Method: Composition-based stats. Identities = 88/348 (25%), Positives = 155/348 (44%), Gaps = 23/348 (6%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 V + D+TLR+G Q + LS+ ++ +A +G++ +EVG + E +AR Sbjct: 2 VGLIDSTLREGLQGVGVELSLDRQVAVAAGSVALGLEELEVGPVGLAAATMEPGDYLARL 61 Query: 65 VKNSR-------VCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 + R + RC+ DI+ + + I S + +KL T E Sbjct: 62 IPRLRHEAGVRRLALWCRCLPDDIERSL----ALNPDVLALSIPASHRQMTSKLGKTAAE 117 Query: 118 VIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMP 177 V A ++ AR + ED R + ++ A++ G + + DTVG + P Sbjct: 118 VRTLAAAALELARGRVPYLALGLEDVTRAEPNFVRQMAVLAVDHGVDRLRLADTVGISAP 177 Query: 178 FEFAGIISGLYERVPNIDK------AIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNG 231 E A ++ + E + I VHTH+D GLA N++AA+ AGA + ++ G Sbjct: 178 DEIADLVGRVREYLREAGGDGRGNQVAIGVHTHNDFGLAGANAIAALAAGADWADVSLLG 237 Query: 232 IGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSG 291 +GERAG LEEV + +R+ + + +Q ++ C IP+ + +VG Sbjct: 238 LGERAGLARLEEVATYLALRRG-----HHYRLERLPELAQQLAGFCGREIPSWRPVVGRD 292 Query: 292 AFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKH 339 F+ +G+H + + +YE PE +G + L ++G A+ Sbjct: 293 VFSCETGLHLAAIQLDPASYEPFAPELVGQRRT-LLYGVKAGHRAIAR 339 >UniRef50_D2VQL9 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2VQL9_NAEGR Length = 422 Score = 212 bits (541), Expect = 2e-53, Method: Composition-based stats. Identities = 62/297 (20%), Positives = 119/297 (40%), Gaps = 31/297 (10%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP-----GDF 55 M V I + RDG Q + + K+ + L G+ +EV VS GD Sbjct: 75 MPSFVKIVEVGPRDGLQNEKKLVPTNVKISLIDKLTEAGLPSVEVTSFVSPKWVPQMGDN 134 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 V T ++ + + L V+ E A + F+A S + T+ Sbjct: 135 FDVFTGIKRREGTAYPVLTPNVK-----GLEQALEAGVKEVAIFLAASDAFSMKNINCTV 189 Query: 116 DEVIERAIYMVKRA-------RNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINI 168 +E +R +++ A R Y V C +G +A+V + G +++ Sbjct: 190 EESFKRYDQVMELAIKNDLKIRGYVSCVA-GCPYSGYVSPETVAQVSYRLLKMGCYEVSL 248 Query: 169 PDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGA 228 DT+G P + ++ + +++P I+VH H+ G A+ N L ++ G V+ + Sbjct: 249 GDTIGVGTPGSVSMLLHQVCKKIPTG---QIAVHFHNTYGQALSNILTSLQFGVETVDSS 305 Query: 229 MNGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNM 279 + G+G +GN S E+V+ + + ++T ++ ++ +S N Sbjct: 306 VAGLGGCPYAKGASGNISTEDVVYMLH----GMGINTGVDLDKLIDAGDYISTYLNR 358 >UniRef50_C0WB33 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria RepID=C0WB33_9FIRM Length = 315 Score = 212 bits (540), Expect = 3e-53, Method: Composition-based stats. Identities = 65/297 (21%), Positives = 120/297 (40%), Gaps = 29/297 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVG---FPVSSPGDFES 57 + +++ I + LRDG Q + + +EKL++ + + G V+EVG P + P + Sbjct: 2 LPKKIRICEVGLRDGLQNEKRMFTTEEKLELLDGMGKAGFSVIEVGSFMSPKAVPQMANT 61 Query: 58 VQTIARQ--VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + + V AL + E ++ ++ S H L T Sbjct: 62 DEVYEKLEKVPGVEYRALIANL-----RGVERAIACGCKKVKLNVSASRAHNLANLNRTP 116 Query: 116 DEVIERAIYMVKRARNYTDDV------EFSCEDAGRTPIADLARVVEAAINAGATTINIP 169 +E + R V A+ ++ F PI +A +VEA + G I++ Sbjct: 117 EESVARFGDCVTCAKEAGLEISGSISMAFGSPWDKEIPIGAVASIVEAYMAVGINEISLS 176 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 D G P + I + + + P K + +H H+ GL + N LA + +G Q + + Sbjct: 177 DASGMAFPPQVQEICAYMKKHYP---KNMWWLHFHNTRGLGMANILAGMQSGFTQFDSSF 233 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMP 280 G+G AGN + E+V+ + + T I+ + S+ V+Q+ P Sbjct: 234 AGVGGCPFVPGAAGNVATEDVLNLCEESG----IDTGIDFDKALEVSRRVAQLVAHP 286 >UniRef50_Q00853 Homocitrate synthase subunit alpha n=8 Tax=Clostridium RepID=NIFVA_CLOPA Length = 269 Score = 212 bits (539), Expect = 4e-53, Method: Composition-based stats. Identities = 84/276 (30%), Positives = 124/276 (44%), Gaps = 10/276 (3%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQ 64 + I DTTLRDGEQ +LSV++K++IA + MGV +E G P + SV IA Sbjct: 3 INIVDTTLRDGEQKAGIALSVQDKVEIAKIISEMGVHQIEAGIPAMGGDEKISVSKIAAL 62 Query: 65 VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 S++ A R KDID + E +H S + I TKL V E Sbjct: 63 GLPSKIAAWNRMSTKDIDTSIE----CGVDIVHISSPVSDLQIKTKLEKDRKWVAENLKR 118 Query: 125 MVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGII 184 V A +V ED+ R + L ++ E G + DTVG P E I Sbjct: 119 TVIYALEKDCEVTVGLEDSSRADLNFLIQLCEMIFALGVKRVRYADTVGIMEPKELYSQI 178 Query: 185 SGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEV 244 + ++VP I +H H+D G+A+ NS AA AGA+ + + G+GERAGNC + Sbjct: 179 KKIRDKVP----IDIEIHVHNDFGMAISNSFAAFKAGAKFADCTITGMGERAGNCDFLKF 234 Query: 245 IMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMP 280 + I+ + ++I + +I + Sbjct: 235 VKVIQELTGEKIYTG--DFEDIIEKENEIKKILRLN 268 >UniRef50_A8MB07 2-isopropylmalate synthase n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8MB07_CALMQ Length = 355 Score = 211 bits (537), Expect = 5e-53, Method: Composition-based stats. Identities = 85/376 (22%), Positives = 158/376 (42%), Gaps = 44/376 (11%) Query: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65 +I D TLR+G QA S +V+EK+++A + GVD V P + + E + I + Sbjct: 1 MIIDDTLREGLQAPGISFTVEEKIELAKLISNAGVDEAIVSHPSAHESEVEVTRIIVERN 60 Query: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125 V L R +++DID+ A + I T+I P + ++ Y Sbjct: 61 YFKYVFGLGRALKEDIDLIASTGAN-----ISTYIPFEPQLVNK--------SLDVIKYA 107 Query: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185 V +E + ++++ ++ + G I + D++G P I++ Sbjct: 108 VNTYGKGKLIIEVGITNITAYELSNIVKLAKTLEELGVDRIQLADSLGKATPKLMYNIVN 167 Query: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245 + V K +SVH H+D+G AV NS+++V+AGA V+ + GIGER G L + Sbjct: 168 NVKHTV----KIPVSVHCHNDMGAAVANSISSVYAGADYVDATIYGIGERNGIADLATIA 223 Query: 246 MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIP-----ANKAIVGSGAFAHSSGIH 300 M ++ + I+ +++ ++++ I N + G+ ++G H Sbjct: 224 MILRN----DSYRINIDFEKLRDAYNYLAKLIIDKIDIEFFRNNFPVFGNNISIQTAGTH 279 Query: 301 QD--GVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYD 358 GV K ++ +L GR+ ++ + E+G ++ L L Sbjct: 280 AAYPGVFK----------------EVGYSLNVYVGRSTLRKVLSELGISLNDQELLMLMR 323 Query: 359 AFLKLADKKGQVFDYD 374 A + G+ YD Sbjct: 324 KIKDTAVRTGRAVTYD 339 >UniRef50_O81027 Hydroxymethylglutaryl-CoA lyase, mitochondrial n=76 Tax=cellular organisms RepID=HMGCL_ARATH Length = 468 Score = 211 bits (537), Expect = 7e-53, Method: Composition-based stats. Identities = 61/305 (20%), Positives = 122/305 (40%), Gaps = 29/305 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP-----GDF 55 + + V I + RDG Q + + K+++ L G+ V+E VS D Sbjct: 164 IPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIQRLVSSGLPVVEATSFVSPKWVPQLADA 223 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + V + +R+ L ++ ++ A A + F + S + + T+ Sbjct: 224 KDVMDAVNTLDGARLPVLTPNLK-----GFQAAVSAGAKEVAIFASASESFSLSNINCTI 278 Query: 116 DEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIP 169 +E + R + A+ ++ V C G + +A VV+ + G I++ Sbjct: 279 EESLLRYRVVATAAKEHSVPVRGYVSCVVGCPVEGPVLPSKVAYVVKELYDMGCFEISLG 338 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G P ++ + VP ++VH HD G A+ N L ++ G V+ ++ Sbjct: 339 DTIGIGTPGSVVPMLEAVMAVVPAD---KLAVHFHDTYGQALANILVSLQMGISIVDSSI 395 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 G+G +GN + E+V+ + VHT ++ ++ +S+ P + Sbjct: 396 AGLGGCPYAKGASGNVATEDVVYMLNGLG----VHTNVDLGKLIAAGDFISKHLGRPNGS 451 Query: 284 NKAIV 288 A+ Sbjct: 452 KAAVA 456 >UniRef50_D0MGG7 Pyruvate carboxyltransferase n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MGG7_RHOM4 Length = 311 Score = 211 bits (536), Expect = 8e-53, Method: Composition-based stats. Identities = 56/302 (18%), Positives = 113/302 (37%), Gaps = 29/302 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVG---FPVSSPGDFES 57 + + I + RDG Q + + K+ + L GV ++V P P ++ Sbjct: 3 LPESASICEVGPRDGFQYETTFIPTERKVAVIERLVEAGVRRIQVTSFVHPKWVPQMADA 62 Query: 58 VQTIARQVK--NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + R + LA V+ E A + IAT H T+ Sbjct: 63 EEVCRRLPDRDDVIFSGLALNVK-----GVERAHAAGLRYVDLSIATHDEHSLANANMTV 117 Query: 116 DEVIERAIYMVKRARNY------TDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIP 169 E + +A M++ A +Y F + G TP+ + + ++ G + ++ Sbjct: 118 AEAVRQAEAMIRLAHHYDMQPQLGLQTVFGYKQPGDTPLQRIRELARRFVDLGLESFSLA 177 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT G P + + + E + + +H HD G+ + N LAA+ G + + ++ Sbjct: 178 DTTGMAHPVQIQEYVEAVREEI---GDTPLVLHLHDTRGMGLANVLAALQCGVTRFDTSL 234 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 G+G GN + E+ + ++ V T I+++ + + + +P Sbjct: 235 GGLGGCPFIPGATGNIATEDTVYMLEAMG----VRTGIDYRRVAELALELEAFLGKELPG 290 Query: 284 NK 285 + Sbjct: 291 RQ 292 >UniRef50_Q28KR2 Hydroxymethylglutaryl-CoA lyase n=5 Tax=Alphaproteobacteria RepID=Q28KR2_JANSC Length = 319 Score = 209 bits (531), Expect = 3e-52, Method: Composition-based stats. Identities = 57/303 (18%), Positives = 113/303 (37%), Gaps = 31/303 (10%) Query: 1 MSQ--QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSS---PGDF 55 M + V + + RDG Q+ + + K++IA A+ G+ ++V VS P Sbjct: 8 MPEGSHVTVCEVGPRDGFQSEKTFIPTARKIEIANAMFAAGLRHIQVTSFVSPRAVPQLA 67 Query: 56 ESVQTIA--RQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRS 113 ++ + IA + + V AL ++ AE A +HT ++ S H + Sbjct: 68 DAAKLIAGLDRPDGAVVSALIPNLK-----GAERAAAAGVDAVHTVVSASETHNLKNVNR 122 Query: 114 TLDEVIERAIYMVKRARNYT------DDVEFSCEDAGRTPIADLARVVEAAINAGATTIN 167 +D+ + + K F C G P +AR+ + GA ++ Sbjct: 123 PIDQSLADFEDVAKLMHREGIVVEGGMATAFGCPFEGVVPPEQVARIARRYQDLGAKRVS 182 Query: 168 IPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEG 227 + DT G P + + P I +H H+ G+ + +A + G + Sbjct: 183 LGDTTGMATPTTVRAAVRAIRAEAPG---VEICLHFHNTRGVGLACVMAGLAEGVSYFDA 239 Query: 228 AMNGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPI 281 A+ G+G GN E+++ ++ T ++ + + + L + + Sbjct: 240 AIGGLGGCPFAAGATGNICTEDLVYLLEESG----YRTGVDLEALISVAGLAQETIGRDL 295 Query: 282 PAN 284 P Sbjct: 296 PGQ 298 >UniRef50_Q15RQ1 Hydroxymethylglutaryl-CoA lyase n=89 Tax=Bacteria RepID=Q15RQ1_PSEA6 Length = 305 Score = 209 bits (531), Expect = 3e-52, Method: Composition-based stats. Identities = 69/312 (22%), Positives = 125/312 (40%), Gaps = 36/312 (11%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSS---PGDFES 57 + +V I + RDG Q +AS+ + K+ + AL + G+ ++E G VS P +S Sbjct: 5 LPSKVKIVEVGPRDGLQNEKASIDLVTKVTLIEALAKSGLSMIETGSFVSPKWVPQMADS 64 Query: 58 VQ--TIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 Q + AL + E+ A A + F + S + ++ Sbjct: 65 AQVFAAINRQDTVIYSALTPNL-----TGFEAALEAGADEVAIFGSASESFSQKNINCSI 119 Query: 116 DEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIP 169 E + R ++ A+ V C G A++A V + G I++ Sbjct: 120 AESLARFEPVIAAAKAKNIKVRGYVSCVLGCPYEGEIAPANVASVAKTLFEMGCYEISLG 179 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G P +++ + + VP ++VH HD G A+ N L A+ G V+ A+ Sbjct: 180 DTIGVGTPIATQIMLNAVLDVVP---LCAVAVHFHDTYGQALANILVALQLGINVVDSAV 236 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNM---- 279 G+G +GN + E+V+ + + + T I+ + + Q V + Sbjct: 237 AGLGGCPYAKGASGNVATEDVVYMLH----GMGIATGIDLSMLAKAGQDVCTKLGINSVS 292 Query: 280 ---PIPANKAIV 288 + ANKA+ Sbjct: 293 KVANVYANKALT 304 >UniRef50_C8WQC0 Pyruvate carboxyltransferase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WQC0_ALIAD Length = 301 Score = 208 bits (530), Expect = 4e-52, Method: Composition-based stats. Identities = 64/301 (21%), Positives = 123/301 (40%), Gaps = 29/301 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP-----GDF 55 M ++V + + RDG Q ++ + K+++ L GV +EV V D Sbjct: 1 MGERVWLREVGPRDGLQNEPGVIATEIKVELVERLMDAGVRFIEVSSFVHPKWIPQLADA 60 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + V R+ + AL + A+ +H F++ S H + T+ Sbjct: 61 DEVFARIRRRPGVELSALVPN-----ERGLARALAAKVDAVHVFMSASESHNLKNINKTI 115 Query: 116 DEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIP 169 + +++ A+ V F C G+ P++ + VVE G + + Sbjct: 116 ADTYPVLRPVIEGAKAEGLVVRGYVSTVFGCPYEGKVPVSQVLSVVERLFELGVDEVALG 175 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G +P + A ++ + VP +S+H HD G+A+ N A AG R+ +G++ Sbjct: 176 DTIGVAVPTQVAEVVREVERIVP---LDRVSLHFHDTRGMAIANMYAGFAAGVRRFDGSI 232 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 G+G +GN ++E+V+ ++V T I + + N P+ + Sbjct: 233 GGLGGCPYAPGASGNVAMEDVLYLFN----GMDVETGIEAERYLDVVAWLESKLNKPLAS 288 Query: 284 N 284 + Sbjct: 289 H 289 >UniRef50_D0Z8X0 Putative hydroxymethylglutaryl-CoA lyase n=1 Tax=Edwardsiella tarda EIB202 RepID=D0Z8X0_EDWTE Length = 312 Score = 207 bits (526), Expect = 1e-51, Method: Composition-based stats. Identities = 58/295 (19%), Positives = 122/295 (41%), Gaps = 30/295 (10%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSS---PGDFES 57 + V + + + RDG Q ++ + + K+ I + R GV +EV VS P ++ Sbjct: 11 LPASVTLTEVSPRDGFQNIEQWIPTETKINIVEGIFRSGVKNIEVTSFVSPKAIPQMKDA 70 Query: 58 V-----QTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLR 112 + + + AL V+ AE +++ I+ SP+H + Sbjct: 71 AIVAEYAVAMAKNTDVNIMALIPNVK-----GAERALSCGIRKVNYIISASPLHNKKNMN 125 Query: 113 STLDEVIERAIYMVKRARN----YTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINI 168 T E E + K F C G+ P+ D+ ++ AA + G + + Sbjct: 126 RTPQESFEALCELKKNFPEADVTLGVATAFGCPFQGKVPVDDVITLMRAARDIGINSFTL 185 Query: 169 PDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGA 228 DT+G P + ++ + + N +++H H+ G+A+ N AA+ G + E A Sbjct: 186 CDTIGVANPRQVETLLHEVKK---NFSDIQLALHLHNTHGMALANIYAAMLQGVDRFESA 242 Query: 229 MNGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQIC 277 + G+G AGN + E+++ + + +++ I+ ++ + + ++ Sbjct: 243 IGGLGGCPFAPGAAGNAATEDLVNMLN----RMEINSNIDLAKLLDVANQIRELV 293 >UniRef50_A9F2G5 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacteria RepID=A9F2G5_SORC5 Length = 328 Score = 206 bits (525), Expect = 1e-51, Method: Composition-based stats. Identities = 61/299 (20%), Positives = 117/299 (39%), Gaps = 29/299 (9%) Query: 2 SQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP-----GDFE 56 + +V I++ + RDG Q A + ++ K ++ AL G+ +E+ VS D E Sbjct: 25 ADEVSIYEVSPRDGLQNESAMIPIEGKRRLIAALVGAGLRRIEITSFVSPKWVPQLADAE 84 Query: 57 SVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 + + AL E I F++ S H + ++D Sbjct: 85 ELARTLPAERGVTFSALCPNA-----RGLERALAVGLREIAVFLSASEAHNRANINKSID 139 Query: 117 EVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIPD 170 + + +V AR V + C G A + R+ E I+ G +++ D Sbjct: 140 DTLSVFSEIVPPAREAGLAVRAYVSTVWGCPYEGDVDPARVVRIAERLIDLGCYQVSLGD 199 Query: 171 TVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMN 230 T+G P + I+ + +P ++H HD G A+ N L + G R + ++ Sbjct: 200 TIGVGTPRQTHDIVRRFLDAMP---PERFALHLHDTRGTALANILVGLELGVRDFDASVA 256 Query: 231 GIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 G+G AGN + E+++ + + V T ++ ++ + Q+ P+P Sbjct: 257 GVGGCPYAPGAAGNMATEDLVFMLH----GMGVRTGVDLDKVIEAGNVAEQVIGRPLPG 311 >UniRef50_Q6MHG9 Hydroxymethylglutaryl-CoA lyase n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MHG9_BDEBA Length = 311 Score = 205 bits (521), Expect = 5e-51, Method: Composition-based stats. Identities = 59/314 (18%), Positives = 115/314 (36%), Gaps = 36/314 (11%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVG---FPVSSPGDFES 57 M + V+I + LRDG Q + L +++ A L G +E+G P P + Sbjct: 1 MKKSVVIVEMGLRDGLQNEKTVLDADTRVEFARRLILAGTKRVEIGAFVSPTWVPQMAGT 60 Query: 58 VQTIARQ---------VKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIA 108 + + + K + L + + + F A S Sbjct: 61 AEVVQKTFALVKSGSIPKKTEFSVLVPN-----ERGMMDAIASGVKEVAIFAACSESFSL 115 Query: 109 TKLRSTLDEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAG 162 + ++DE +R ++ A+ + V F C GR A + ++ + G Sbjct: 116 KNINCSIDESFKRFEPVMALAKKHKIKVRGYLSTCFGCPFEGRVSEAKVVKLAQRMHKLG 175 Query: 163 ATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGA 222 ++I DT+G + + + + ++ H HD G A+ N LAA G Sbjct: 176 VYELSIGDTIGVADVGQVESLFR---KLKKVVPVKKLAGHFHDTRGQALANILAAYKLGI 232 Query: 223 RQVEGAMNGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQI 276 + ++ G+G GN + E+V+ + V T +N ++ + +++ Sbjct: 233 NVFDTSLGGLGGCPYAPGATGNVATEDVVYMFH----GMGVKTGLNLDKLIEINPWMAEK 288 Query: 277 CNMPIPANKAIVGS 290 P+P+ VG Sbjct: 289 IQHPLPSKVGKVGR 302 >UniRef50_A4X0W1 Pyruvate carboxyltransferase n=3 Tax=Actinomycetales RepID=A4X0W1_SALTO Length = 303 Score = 204 bits (519), Expect = 7e-51, Method: Composition-based stats. Identities = 60/300 (20%), Positives = 113/300 (37%), Gaps = 30/300 (10%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPG-----DF 55 M V I + RDG Q + + K+++ AL R GV +E V D Sbjct: 1 MPGFVSIREVGPRDGLQNE-EPIPTEAKVRLLDALSRTGVGRIEAVSFVHPKAIPQMADA 59 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 + V A Q + R AL A A I ++ S H + + Sbjct: 60 DEVWRRAEQTEGVRYSALVPNT-----RGAHRALAAGFTEIEVVVSASDTHNRRNVNRST 114 Query: 116 DEVIERAIYMVKRARNYTDD------VEFSCEDAGRTPIADLARVVEAAINAGATTINIP 169 +E ++ +V+ + F C G +A +V+ + GA + Sbjct: 115 EESLDDIAELVELLHHAGARAEVIIATSFGCPYEGDIDPVRVAGIVDRVVRDGADRVAFG 174 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT G P +++ + +R ++ + +H H+ G A+ N L A+ G + + ++ Sbjct: 175 DTTGMATPRRVRELVTAVRDRDAHL---PLLLHFHNTRGAALANLLTAIELGVTEFDASV 231 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 G+G +GN + EE + + V T I+ + ++L ++ +P+ Sbjct: 232 GGLGGCPYAPGASGNLATEEAVHLLHDMG----VDTGIDLAALIEVAELAEELVGRSLPS 287 >UniRef50_C6JJQ3 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria RepID=C6JJQ3_FUSVA Length = 303 Score = 202 bits (515), Expect = 2e-50, Method: Composition-based stats. Identities = 66/304 (21%), Positives = 121/304 (39%), Gaps = 29/304 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGF---PVSSPGDFES 57 + ++V I + RDG Q ++ + K KL+I +LE G + +E+ P P +S Sbjct: 3 LPEKVQIVEVGPRDGFQNIKTFIETKHKLEIIDSLEEAGCNKIEITSFVNPKWIPQMVDS 62 Query: 58 VQTIARQVKNS----RVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRS 113 + VK + V L E+ + A I I+ S H + Sbjct: 63 KEICETCVKKNERKYEVIVLCPN-----KKGIENAISSGAEVISVVISVSEAHNKANVNR 117 Query: 114 TLDEVIERAIYMVKRARNYTDD----VEFSCEDAGRTPIADLARVVEAAINAGATTINIP 169 T++E + MV + N F C ++ ++E A G I + Sbjct: 118 TVEESFKELEEMVYKYPNMKFRLDLATVFGCPFGEEIKPERVSELIEKAKKIGVKEIMLA 177 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DTVG P I+ + E+V I +H HD G+ + N L A+ G E ++ Sbjct: 178 DTVGLGNPVLVEKILKQVKEQV---GTENIILHIHDTRGMGLANMLVALQLGYSIFETSI 234 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 G+G AGN + E+ + + + ++ I+ ++++ T L+ Q ++ + Sbjct: 235 GGLGGCPFAPGAAGNVATEDFVNMLN----GMGINHNIHLEKLYHTLDLIDQYVDVNLNN 290 Query: 284 NKAI 287 + Sbjct: 291 SHMY 294 >UniRef50_A8FDY7 Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacillus pumilus RepID=A8FDY7_BACP2 Length = 302 Score = 202 bits (514), Expect = 2e-50, Method: Composition-based stats. Identities = 60/300 (20%), Positives = 116/300 (38%), Gaps = 27/300 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVG---FPVSSPGDFES 57 + ++V+I + RDG Q L EK + L + +EV P P ++ Sbjct: 3 LPKRVLIREVGPRDGLQNESTWLDTSEKQRWIELLTAARLPYIEVTSFVHPKWVPALKDA 62 Query: 58 VQTIARQVKNSRVC-ALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 + K + A EK + E+ A FI++S H + ++ Sbjct: 63 KELAQSLHKKGDITYAALIPNEKGLAHFFEANLDTGA----MFISSSETHNKKNMNQSIQ 118 Query: 117 EVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIPD 170 E + M + F C + P+ + R+ E ++ G I++ D Sbjct: 119 ETLPVIKQMTADLKAAGKHTRAYISTVFGCPYEHQVPMDQVLRLTEMLLSYGIDEISLGD 178 Query: 171 TVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMN 230 T+G P + + L ER P I++H HD G+ + N A+ AG + + Sbjct: 179 TIGEAHPLQVERRLDILLERFPAD---KIALHFHDTKGMGLANIYTALKAGITIFDASSG 235 Query: 231 GIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 G+G +GN + E+V+ ++ + T IN + + ++ + + +P++ Sbjct: 236 GLGGCPYAPGSSGNVATEDVVHMLQKLG----IDTNINFPALIKAAEWIETKVDRTLPSH 291 >UniRef50_C7MUV0 Hydroxymethylglutaryl-CoA lyase n=5 Tax=cellular organisms RepID=C7MUV0_SACVD Length = 314 Score = 202 bits (514), Expect = 3e-50, Method: Composition-based stats. Identities = 65/301 (21%), Positives = 115/301 (38%), Gaps = 28/301 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP-----GDF 55 + ++V I++ RDG Q + ++ V KL+ L G+ +E V D Sbjct: 18 LPERVTIWEVGPRDGLQNERTTVPVDVKLEFLDRLADAGLTTVEATSFVHPKWVPQLADA 77 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 E + R+ R L + + A + F + + L S L Sbjct: 78 EELLARLRRRDGVRYPVLVPN-----ERGLDRALAAGVTHVAVFASATESFARRNLNSGL 132 Query: 116 DEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINIP 169 D ++ RAR DV F G P + V ++AG T +++ Sbjct: 133 DAQFAMFEPVIARAREAGLDVRGYVSMCFGDPWEGIVPTEQVVTVGRRLLDAGCTQLSLG 192 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G ++ E + A ++VH HD G A+ N+LAA+ G V+ + Sbjct: 193 DTIGVATAAAVERLLDAFIE--GGVAIADLAVHFHDTYGQALANTLAALRKGVTTVDASA 250 Query: 230 NGIGE------RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 G+G GN + E+++ + D L V ++ + TS+ +S+ P+ Sbjct: 251 GGLGGCPYAESATGNLATEDLVWLL----DGLGVEHGVDLDALVETSRWMSRQLGRSSPS 306 Query: 284 N 284 Sbjct: 307 R 307 >UniRef50_A4VK95 Hydroxymethylglutaryl-CoA lyase n=63 Tax=cellular organisms RepID=A4VK95_PSEU5 Length = 338 Score = 201 bits (512), Expect = 4e-50, Method: Composition-based stats. Identities = 58/300 (19%), Positives = 117/300 (39%), Gaps = 29/300 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPG-----DF 55 MS+++ I + RDG Q + + K+ + L + G+ +EV S D Sbjct: 31 MSKRLHIQEVATRDGFQIEANFVPTEAKIALIDRLSQTGLAKIEVTSFTSPKAIPNLRDA 90 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 E V R+ + L E E I+ ++ S H LR T Sbjct: 91 EDVMRGIRRAEGVEYTVLVPNA-----RGCERALACEVDEINLVMSASDTHGLANLRMTP 145 Query: 116 DEVIERAIYMVKRARNYTD------DVEFSCEDAGRTPIADLARVVEAAINAGATTINIP 169 ++ + + +++ R F C G P + +V+ + G I + Sbjct: 146 EQSLVQFREIIEVTRGSGVFINASLSTTFGCPFEGDVPERRIYELVQRLLEIGVQGITLC 205 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT G P + I + R P+ A+ + H H+ G+ + N+LAA++AG + + ++ Sbjct: 206 DTTGMADPAQVERICREVLSRWPD---AVFTAHFHNTRGMGLANALAALNAGIDRFDASL 262 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPA 283 G+G +GN E+++ + + T ++ + ++ + + +P+ Sbjct: 263 GGLGGCPYAPGASGNICTEDLVHMFQRMG----LETGVDLDRLLEAAERLPMLVGHDVPS 318 >UniRef50_C6PWR8 Pyruvate carboxyltransferase n=1 Tax=Clostridium carboxidivorans P7 RepID=C6PWR8_9CLOT Length = 303 Score = 201 bits (511), Expect = 5e-50, Method: Composition-based stats. Identities = 59/305 (19%), Positives = 115/305 (37%), Gaps = 26/305 (8%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPG-----DFES 57 ++ + + RDG Q L+ + + K+++ L G+ ME+ V D E+ Sbjct: 5 DRIKVVEVGPRDGLQNLKNWIPTEVKIKLIKDLIDAGIKEMEMTSFVHPKAIPQMKDAEA 64 Query: 58 -VQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 + + ++ + A V A+ I I+ S H + T+ Sbjct: 65 VTKAVIDELNEKEIRTFALVPNL---VGAKKAYGCGLREITYVISASEKHNLANINRTVQ 121 Query: 117 EVIERAIYMVKRA----RNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTV 172 + +E + F C G+ + ++ +A G TI + DT+ Sbjct: 122 QSLEGLADIRAELPDIQIRLDVATAFGCPFMGQVGEDLVINLIRSAEKIGINTITLCDTI 181 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G P + + + + N + +H HD G+ + N LAA+ AG E ++ G+ Sbjct: 182 GIANPKQVYELSQKVSKEFQN---IPVGLHLHDTRGMGIANYLAAIEAGISVFETSIGGL 238 Query: 233 G------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKA 286 G AGN + E+++ + K V T I+ + S+ + + +M + Sbjct: 239 GGCPFAPGAAGNTATEDLVNMLNEIK----VETNIDLNALVSISKELEEKLDMNFTGHMV 294 Query: 287 IVGSG 291 V S Sbjct: 295 HVKSN 299 >UniRef50_B4BIN3 Pyruvate carboxyltransferase n=1 Tax=Geobacillus sp. G11MC16 RepID=B4BIN3_9BACI Length = 300 Score = 201 bits (511), Expect = 6e-50, Method: Composition-based stats. Identities = 61/294 (20%), Positives = 121/294 (41%), Gaps = 30/294 (10%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSS---PGDFES 57 M V I D + RDG Q Q +S ++K + L + + +E V P ++ Sbjct: 1 MP-DVQIIDVSPRDGLQNEQVIVSSEKKRMLIEMLVKSNIRKIEATSFVHPLKVPQMADA 59 Query: 58 VQ--TIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 Q + ++ + AL ++ + K + I+ A + + ++ Sbjct: 60 EQVLKLCEELSEIELVALIPNLK-----GFQRAKQTKISEINWVTAATETFNYKNIGMSI 114 Query: 116 DEVIERAIYMVKRARNYTDD------VEFSCEDAGRTPIADLARVVEAAINAGATTINIP 169 ++ + +V+ +R V F C G+ + +VE AI AGA I I Sbjct: 115 EDNFAQFKQLVQESRTLNITICFSIAVSFGCPYEGKVSPVKVISLVERAIEAGANRIGIA 174 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G P + +++ + + I++H HD G+ + N+ AA+ AG + E + Sbjct: 175 DTIGIATPKQVKELLTEV---LHIAKSIPIAIHLHDTRGMGLANAYAALEAGVKIFETSA 231 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQIC 277 +GIG AGN + E+++ + V T I+ +++ + + + Sbjct: 232 SGIGGCPFAPGAAGNLATEDLVYMFERMG----VKTGIDFEKLLDAADFAASLT 281 >UniRef50_Q2C751 Putative hydroxymethylglutaryl-CoA lyase n=3 Tax=cellular organisms RepID=Q2C751_9GAMM Length = 313 Score = 200 bits (510), Expect = 8e-50, Method: Composition-based stats. Identities = 62/310 (20%), Positives = 122/310 (39%), Gaps = 34/310 (10%) Query: 1 MSQQVIIFDTTLRDGEQALQASLS-----VKEKLQIALALERMGVDVMEVGFPVSSP--- 52 + + +F+ RDG Q + K+ + L + G+ +E G VS Sbjct: 11 LPDAITVFEVGPRDGLQNEPHLSTLGGKATALKIALINELGQTGLTHIESGAFVSPKMIP 70 Query: 53 --GDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATK 110 D + V + ++ N AL + E+ A + F + S Sbjct: 71 TMADSDIVFSHIQRHPNIFYSALTPNL-----QGLEAAINVNANEVAIFTSCSETFTQKN 125 Query: 111 LRSTLDEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGAT 164 + +++DE ++R ++ A + V C G+T +A + + I+ G Sbjct: 126 IHASIDESLQRFESVIAIAHQHLIPVRAYLSCVIDCPYEGKTLPQQVAEIAKTLIDMGCY 185 Query: 165 TINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQ 224 +++ DT+G P A ++ + + + I+VH HD G A+ N A+ G Sbjct: 186 QVSLGDTIGTGTPLRVANMLEYVNKHI---QSKAIAVHFHDSYGQALANIYQAIQMGITT 242 Query: 225 VEGAMNGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICN 278 ++ ++ G+G +GN + E+VI LN+ T I+ +++ SQ Q Sbjct: 243 IDSSIAGLGGCPYAPGSSGNVATEDVIY----LCQGLNIKTGIDLEKLTLISQKFCQQLG 298 Query: 279 MPIPANKAIV 288 + + A+ Sbjct: 299 IRPQSKVALA 308 >UniRef50_C1D9E0 Hydroxymethylglutaryl-CoA lyase n=9 Tax=cellular organisms RepID=C1D9E0_LARHH Length = 306 Score = 200 bits (509), Expect = 9e-50, Method: Composition-based stats. Identities = 64/304 (21%), Positives = 112/304 (36%), Gaps = 30/304 (9%) Query: 1 MSQQ-VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSS---PGDFE 56 MS+ V + + RDG Q SL V ++++ L G+ V+E G VS P Sbjct: 1 MSKHHVTLVEVGPRDGLQNESRSLPVGLRVELVERLVAAGLSVIEAGSFVSPKWVPQMAG 60 Query: 57 SVQTIARQVK--NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRST 114 + + +A R+ L ++ A I F A S L + Sbjct: 61 TAEVLAGIAPAPGLRLPVLVPNR-----QGLQAAMDAGVREIAVFTAASETFAFKNLNCS 115 Query: 115 LDEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAGATTINI 168 + + + R ++ AR V C G + V + + G I++ Sbjct: 116 IGDSLVRFAPVIDEARLAGLRVRGYVSCVLGCPYEGSVAPERVVDVSASLLKLGCDEISL 175 Query: 169 PDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGA 228 DT+G P +I L VP ++ H HD G+A N AA G R + + Sbjct: 176 GDTIGAGTPDTTRRLIRELAREVP---VERLAGHFHDTWGMAAANVYAAWLEGMRTFDCS 232 Query: 229 MNGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIP 282 + G+G GN + E+++ D + + T ++ + T+ +S+ Sbjct: 233 VGGLGGCPYAPGATGNVATEDLVH----LFDGMGITTGVSLAAVVETAHWISRQLGRQPA 288 Query: 283 ANKA 286 + A Sbjct: 289 SRAA 292 >UniRef50_A8MEN7 Pyruvate carboxyltransferase n=1 Tax=Alkaliphilus oremlandii OhILAs RepID=A8MEN7_ALKOO Length = 306 Score = 199 bits (505), Expect = 3e-49, Method: Composition-based stats. Identities = 66/305 (21%), Positives = 122/305 (40%), Gaps = 31/305 (10%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSS---PGDFES 57 + + V I + RDG Q ++ ++ ++K+ I L +E+G VS P ++ Sbjct: 3 IPKSVEILEVCPRDGFQNVKDFIATEDKIAIVERLIDANFKRIELGSFVSPKAIPQMADT 62 Query: 58 VQTIARQVKNS-----RVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLR 112 + +A + + + AL ES A +I I+ S H + Sbjct: 63 KEVVAAAKQYAVDQDIKFVALVPNA-----RGVESAIAAGVDQITYVISASESHNKANVN 117 Query: 113 STLDEVIERAIYMVKRARN-----YTDDVEFSCEDAGRTPIADLARVVEAAINAGATTIN 167 T+ E +E+ ++K + F C I + + + A + G I Sbjct: 118 RTVAESMEQYEALIKEYKGDIDFRLGLATTFGCPFGDEVKIERIQEMCKWAFDLGTVEIL 177 Query: 168 IPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEG 227 + DTVG P + + ++ L V +H HD GLA+ N+LAA+ G + E Sbjct: 178 MADTVGLGNPKKVSEVMRTL---VNEFGPEKFVMHLHDTRGLALANTLAAMQYGITKFES 234 Query: 228 AMNGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPI 281 A G+G +GN + E++ + + T I ++++ QL+ N I Sbjct: 235 ATGGLGGCPFAPGASGNAATEDLYYMLSEMG----IETNIEIEKVYEAIQLIKDKVNTTI 290 Query: 282 PANKA 286 ++ A Sbjct: 291 VSHLA 295 >UniRef50_B6QTB6 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase n=2 Tax=Trichocomaceae RepID=B6QTB6_PENMQ Length = 564 Score = 199 bits (505), Expect = 3e-49, Method: Composition-based stats. Identities = 62/302 (20%), Positives = 121/302 (40%), Gaps = 30/302 (9%) Query: 1 MSQ----QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSS---PG 53 M++ +V I + RDG Q+++ ++ + K ++ L R G+ +E+ VS+ P Sbjct: 1 MTRPKVPEVRIVEVGPRDGLQSIKDAVPTETKTELIQRLWRAGLRSIELTSIVSTRKVPQ 60 Query: 54 DFESVQ-----TIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIA 108 + + I ++S L V + + FI+ + Sbjct: 61 LADCQEILNNPAIRSLTEDSEASGLRLPVLTPNLKGLDIALSRGVKEVAVFISATEGFSQ 120 Query: 109 TKLRSTLDEVIERAIYMVKRARNYTDDVE------FSCEDAGRTPIADLARVVEAAINAG 162 + ++++ +E+A + ++A V F G T + + R V+ + G Sbjct: 121 ANINCSVEQGVEKARAVAQKAIEAGIAVRGYVSCIFVDPYDGPTNPSSVLRCVQELLQMG 180 Query: 163 ATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGA 222 +++ DT G P + A +I L + + ++ H HD G AV N L A G Sbjct: 181 CYEVSLGDTTGAGTPAKVATLIRYLEKN--GVSLRNLAGHFHDTYGQAVANVLQAYICGI 238 Query: 223 RQVEGAMNGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQI 276 R + ++ G+G GN S EEV+ + + T +N +E+ T ++Q Sbjct: 239 RVFDASVGGLGGCPFAPGAKGNVSTEEVVFMFQNAG----IQTGVNLEELVATGNWINQQ 294 Query: 277 CN 278 Sbjct: 295 VR 296 >UniRef50_D1TMW3 Hydroxymethylglutaryl-CoA lyase n=1 Tax=Burkholderia sp. CCGE1002 RepID=D1TMW3_9BURK Length = 338 Score = 198 bits (504), Expect = 4e-49, Method: Composition-based stats. Identities = 58/309 (18%), Positives = 114/309 (36%), Gaps = 30/309 (9%) Query: 3 QQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPG-----DFES 57 + V I D +RDG Q + EK+ + + G++ +E S+ D E+ Sbjct: 10 ESVWINDVVMRDGLQMEPVFVPTSEKVALIDEIGHCGLNRIEATSFTSAKAIPALSDAEA 69 Query: 58 VQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDE 117 V +V R AL AE ++ ++ S H R T + Sbjct: 70 VMHEIERVPGVRYAALVLNR-----RGAERALECGVDELNLGVSASETHNLANTRMTRAQ 124 Query: 118 VIERAIYMVKRARNY-----TDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTV 172 + + + R+ + F C G I + + + AG I + DT Sbjct: 125 AVRALLDITAFCRDRLAIGVSIATAFGCPMEGAIDIDSVLDIGNQFVAAGVRGITLCDTT 184 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G P + + L R +++H H+ G+ + N +A + AG R + ++ G+ Sbjct: 185 GMANPRQVKAVCGALAARW---RGIELTLHLHNTRGMGLANVVAGLDAGIRHFDASLGGL 241 Query: 233 G------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKA 286 G +GN E+++ + D + T ++ + + ++ + + +P Sbjct: 242 GGCPFAPGASGNICTEDLVHML----DAMGYATGVDLERLIACARRMPGLVGHGVPGQVQ 297 Query: 287 IVGSGAFAH 295 G A+ H Sbjct: 298 HAG--AWDH 304 >UniRef50_B4VB43 2-isopropylmalate synthase n=1 Tax=Streptomyces sp. Mg1 RepID=B4VB43_9ACTO Length = 474 Score = 198 bits (504), Expect = 4e-49, Method: Composition-based stats. Identities = 83/394 (21%), Positives = 168/394 (42%), Gaps = 22/394 (5%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERM-GVD-----VMEVGFPVSSPGDFES 57 +V++++ + RDG QA + ++ ++++A R+ G D V+ GFP +FE+ Sbjct: 53 RVVLWEESARDGAQA-KTLMTAGFRVRLARETGRIFGSDGPRHVVIAAGFPAVCGEEFEA 111 Query: 58 VQTIARQVKNSR-VCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 V+ +A + + + V A+ R +D++ A S++ + R+ + S + Sbjct: 112 VRRVAGEAEGAVSVAAVCRGARRDLEQAVASVRGSRQARVMVVVPASEAMARVMVHRAAR 171 Query: 117 EVIERAIYMVKRARNY--TDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGY 174 E ++ + +VKRAR+ V+ DA R A +A A AGA + + DTVG Sbjct: 172 EALQAGVDLVKRARDLDEGVAVDVCLADASRADHALMAHYARAMTGAGAGLVVLADTVGA 231 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 +P A + + + + +++ H H+DLGL + N+L A+ AG R + GI E Sbjct: 232 QLPSGCAEMFRRVRAEAGS--EVVLASHLHNDLGLGLANTLEALAAGVRVASSSWLGIAE 289 Query: 235 RAGNCSLEEVIMAIKVR------KDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIV 288 RAG + E+++ + + + + +++V+ +P+ IV Sbjct: 290 RAGMVATEQLLFLLARHARELLGAGAAPWWSPPDLTRLPVIAEMVAGETGVPLGVTTPIV 349 Query: 289 GSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE 348 G+G + S+G + ++ P+ + ++ LT + V +G+ Sbjct: 350 GTGVGSLSTGT----PFVHPRLFQPYDPQELLGITPRVVLTHLASARVVAAVATRLGHTL 405 Query: 349 SEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIG 382 A + G+ D ++ Sbjct: 406 DGERTRTAMAWVKGRAYRTGRAVVEDDAFADYLD 439 >UniRef50_Q146L0 Hydroxymethylglutaryl-CoA lyase n=18 Tax=cellular organisms RepID=Q146L0_BURXL Length = 309 Score = 198 bits (504), Expect = 4e-49, Method: Composition-based stats. Identities = 63/297 (21%), Positives = 104/297 (35%), Gaps = 29/297 (9%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP-----GDF 55 + QQV I + RDG Q + + K+++ L G +E VS D Sbjct: 3 LPQQVKIVEVGPRDGLQNEKEFVPTATKIELINRLSAAGFRNVEAASFVSPKWVPQMADG 62 Query: 56 ESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115 V + + L + E A A I F A S + ++ Sbjct: 63 ADVMAGIERRPGTIYSVLTPNL-----RGFEGALAARADEIVIFGAASEAFSQKNINCSI 117 Query: 116 DEVIERAIYMVKRARNYTDDV------EFSCEDAGRTPIADLARVVEAAINAGATTINIP 169 E I R + + A+ + + C G P+A + VVE G I+I Sbjct: 118 AESIGRFAPVAQAAKEHGVRIRGSVSCALGCPYQGEVPVASVVDVVERFAALGCDEIDIA 177 Query: 170 DTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAM 229 DT+G P + + P + +S H HD G A+ N AA+ G ++ Sbjct: 178 DTIGVGTPKRTREVFEAVTRVFP---RERLSGHFHDTYGQALANIYAALLEGIEIYHASV 234 Query: 230 NGIG------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMP 280 G+G GN + E+V+ + + T I+ ++ +S P Sbjct: 235 AGLGGCPYAKGATGNVATEDVLYLMNGLG----IETGIDLAQVVAIGDFISTSIGRP 287 >UniRef50_Q5WKL8 Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillaceae RepID=Q5WKL8_BACSK Length = 309 Score = 198 bits (504), Expect = 4e-49, Method: Composition-based stats. Identities = 62/293 (21%), Positives = 109/293 (37%), Gaps = 27/293 (9%) Query: 5 VIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSP-----GDFESVQ 59 V I + RDG Q Q LSV++K+++ R G+ +E V+ D E V Sbjct: 13 VEICEVGPRDGLQNEQVRLSVEQKIEMMEHAARSGISKIEAVSFVNKKLVPAMADAEEVM 72 Query: 60 TIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVI 119 + + R+ LA +H I+ S T+ E + Sbjct: 73 AAWHRREGVRIAGLALSRS-----GITRALQTPIDVLHITISASDAFNKRNANKTVAEGL 127 Query: 120 ERAIYMVKRARNY-----TDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGY 174 + +V A + F C +G + + V E+ + AGAT + + DT G Sbjct: 128 SDLLPVVGEASTHLPVVTVISTSFGCPFSGDVQMETVFSVCESFLKAGATEMVLADTTGM 187 Query: 175 TMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGE 234 P + A + G Y + +H H+ GL + N++A AG R+ + A+ G+G Sbjct: 188 ANPRQVAETVRGFYRTFGE--DIPLGLHFHNTRGLGLANAVAGYDAGVRRFDSAVGGLGG 245 Query: 235 ------RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPI 281 GN E+++ + T + + +Q V + + Sbjct: 246 CPFAPKATGNICTEDLVHMFHEMG----IDTGTDLDGLITLAQQVEKWMGKRL 294 >UniRef50_A3JC95 Pyruvate carboxyltransferase n=5 Tax=Gammaproteobacteria RepID=A3JC95_9ALTE Length = 308 Score = 198 bits (503), Expect = 5e-49, Method: Composition-based stats. Identities = 68/295 (23%), Positives = 130/295 (44%), Gaps = 29/295 (9%) Query: 4 QVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSS---PGDF--ESV 58 ++ I + RDG Q+ +LSV+++L + AL ++G+ +E G VS P + + Sbjct: 2 KIRINEVGPRDGLQSQGKTLSVEDRLSLIQALVKVGLKNVEAGSFVSPKAVPQMAGTDDL 61 Query: 59 QTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEV 118 + + R L ++ E A A ++ ++ + +R +L + Sbjct: 62 FALLPERSAVRYAGLVPNMK-----GYELAVAAGANVVNVVLSVTETMNQKNIRMSLPQT 116 Query: 119 IERAIYMVKRARNYTDDV------EFSCEDAGRTPIADLARVVEAAINAGATTINIPDTV 172 +E +++R R +V F C G A +AR+ + AGA+ I I DT+ Sbjct: 117 VEVCTAIIERGRCEGVEVQAYLAVAFECPFEGLVEPAVVARLAKRLEQAGASKIIIADTI 176 Query: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232 G P +++G+ + + I+S H HD G+A+ N AA+ G R+ + ++ G+ Sbjct: 177 GAANPEHVRRLLNGV---ISEVGSDILSCHFHDTRGIALANITAALDHGIREFDTSIGGL 233 Query: 233 G------ERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPI 281 G GN + E+V++ + T IN ++ L Q+ +P+ Sbjct: 234 GGCPFSPGATGNVATEDVVLLLNSMGH----DTGINPFDLVPVVCLAEQLTGVPL 284 >UniRef50_B4RE97 3-hydroxy-3-methylglutarate-CoA lyase n=4 Tax=Bacteria RepID=B4RE97_PHEZH Length = 309 Score = 198 bits (503), Expect = 5e-49, Method: Composition-based stats. Identities = 60/306 (19%), Positives = 114/306 (37%), Gaps = 23/306 (7%) Query: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSS---PGDFES 57 MS+++ I + RDG Q + L V +KL++ LE G MEV V+ P + Sbjct: 1 MSRRIEIVEVGPRDGLQNEKTLLEVDQKLEMIRRLEDAGARRMEVVSFVNPRRVPQMAGA 60 Query: 58 VQTIARQV-KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLD 116 + +A ++ +R E A + + S +++ Sbjct: 61 EEIMAALNTPGAKPAGRSRIGLVLNQKGWERCVAAACDEANVVVCASDGFGIRNQGASVA 120 Query: 117 EVIERAIYMVKRAR------NYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPD 170 E I+ +++ R T V F C G P + +V A + I + D Sbjct: 121 EQIDALGAIMQARRLEDPPVTVTVSVAFGCPFDGEVPEERVVDIVRTAADMRVAEIALAD 180 Query: 171 TVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMN 230 T+G P+ + + + + +H HD + N+ A V AG ++ ++ Sbjct: 181 TIGVADPWTVRRRVEAARKA---AGRIPLRLHFHDTRNTGLANAYAGVEAGVDILDASVG 237 Query: 231 GIGE------RAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPAN 284 G+G GN E+++ ++ T + ++ + VS + P ++ Sbjct: 238 GLGGCPFAPNATGNIGTEDLVYMLERGG----FETGYDLDKLIEIGRWVSGLLGKPPASS 293 Query: 285 KAIVGS 290 A GS Sbjct: 294 LARAGS 299 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.311 0.141 0.357 Lambda K H 0.267 0.0433 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 2,706,906,950 Number of Sequences: 3077464 Number of extensions: 110185197 Number of successful extensions: 363174 Number of sequences better than 1.0e-01: 250 Number of HSP's better than 0.1 without gapping: 1275 Number of HSP's successfully gapped in prelim test: 271 Number of HSP's that attempted gapping in prelim test: 357494 Number of HSP's gapped (non-prelim): 1771 length of query: 523 length of database: 1,040,396,356 effective HSP length: 133 effective length of query: 390 effective length of database: 631,093,644 effective search space: 246126521160 effective search space used: 246126521160 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 96 (41.5 bits)