BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (313 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_B7LU53 Porphobilinogen deaminase n=87 Tax=cellular orga... 447 e-124 UniRef50_B5FN93 Porphobilinogen deaminase n=168 Tax=cellular org... 440 e-122 UniRef50_Q3ACT3 Porphobilinogen deaminase n=2 Tax=Bacteria RepID... 436 e-121 UniRef50_C0QU69 Porphobilinogen deaminase n=4 Tax=Bacteria RepID... 435 e-120 UniRef50_B5YJZ4 Porphobilinogen deaminase n=2 Tax=Bacteria RepID... 429 e-119 UniRef50_C0Q9U2 HemC n=2 Tax=Bacteria RepID=C0Q9U2_DESAH 428 e-118 UniRef50_Q8YVU6 Porphobilinogen deaminase n=50 Tax=cellular orga... 423 e-117 UniRef50_D1BNZ5 Porphobilinogen deaminase n=3 Tax=Veillonella Re... 422 e-117 UniRef50_Q8DIE4 Porphobilinogen deaminase n=11 Tax=cellular orga... 419 e-116 UniRef50_Q0I178 Porphobilinogen deaminase n=45 Tax=Bacteria RepI... 415 e-115 UniRef50_Q65GK1 Porphobilinogen deaminase n=98 Tax=Bacillales Re... 414 e-114 UniRef50_A1AUE7 Porphobilinogen deaminase n=44 Tax=Bacteria RepI... 413 e-114 UniRef50_B5EBG8 Porphobilinogen deaminase n=166 Tax=Bacteria Rep... 411 e-113 UniRef50_A6TJD5 Porphobilinogen deaminase n=2 Tax=Firmicutes Rep... 410 e-113 UniRef50_C9KL85 Hydroxymethylbilane synthase n=1 Tax=Mitsuokella... 409 e-113 UniRef50_Q31PM2 Porphobilinogen deaminase n=8 Tax=cellular organ... 406 e-112 UniRef50_C6HUG2 Porphobilinogen deaminase n=1 Tax=Leptospirillum... 402 e-110 UniRef50_Q5ZRY6 Porphobilinogen deaminase n=6 Tax=Legionella Rep... 399 e-110 UniRef50_Q2RJ26 Porphobilinogen deaminase n=5 Tax=Clostridia Rep... 397 e-109 UniRef50_P08397 Porphobilinogen deaminase n=59 Tax=Chordata RepI... 394 e-108 UniRef50_B2A1G7 Porphobilinogen deaminase n=1 Tax=Natranaerobius... 393 e-108 UniRef50_Q30Y29 Porphobilinogen deaminase n=13 Tax=Bacteria RepI... 393 e-108 UniRef50_Q4L709 Porphobilinogen deaminase n=88 Tax=Bacillales Re... 391 e-107 UniRef50_B3QWI1 Porphobilinogen deaminase n=12 Tax=Chlorobiaceae... 390 e-107 UniRef50_C9R7U0 Porphobilinogen deaminase n=1 Tax=Ammonifex dege... 390 e-107 UniRef50_B3E2H7 Porphobilinogen deaminase n=3 Tax=Proteobacteria... 389 e-107 UniRef50_Q54P93 Porphobilinogen deaminase n=1 Tax=Dictyostelium ... 388 e-106 UniRef50_Q2LQU2 Porphobilinogen deaminase n=1 Tax=Syntrophus aci... 385 e-105 UniRef50_A8PKX6 Porphobilinogen deaminase n=2 Tax=Gammaproteobac... 384 e-105 UniRef50_A7NKU8 Porphobilinogen deaminase n=5 Tax=Bacteria RepID... 382 e-105 UniRef50_A3ETN3 Porphobilinogen deaminase n=2 Tax=Leptospirillum... 382 e-105 UniRef50_Q1J288 Porphobilinogen deaminase n=5 Tax=Deinococci Rep... 382 e-104 UniRef50_Q180R9 Porphobilinogen deaminase n=11 Tax=Bacteria RepI... 380 e-104 UniRef50_A6WXJ2 Porphobilinogen deaminase n=56 Tax=cellular orga... 380 e-104 UniRef50_B6FXV9 Putative uncharacterized protein n=1 Tax=Clostri... 379 e-104 UniRef50_B2S842 Porphobilinogen deaminase n=38 Tax=Rhizobiales R... 377 e-103 UniRef50_A7GYU4 Porphobilinogen deaminase n=34 Tax=Campylobacter... 377 e-103 UniRef50_O94048 Porphobilinogen deaminase n=53 Tax=Saccharomycet... 375 e-103 UniRef50_A6Q7Y4 Porphobilinogen deaminase n=7 Tax=Epsilonproteob... 375 e-102 UniRef50_D0LUE1 Porphobilinogen deaminase n=1 Tax=Haliangium och... 373 e-102 UniRef50_Q43316 Porphobilinogen deaminase, chloroplastic n=61 Ta... 372 e-102 UniRef50_D2R3S6 Porphobilinogen deaminase n=2 Tax=Planctomycetac... 372 e-102 UniRef50_P28789 Porphobilinogen deaminase n=18 Tax=Saccharomycet... 371 e-101 UniRef50_A5VM67 Porphobilinogen deaminase n=9 Tax=Lactobacillus ... 370 e-101 UniRef50_Q8RFP5 Porphobilinogen deaminase n=16 Tax=Fusobacteriac... 370 e-101 UniRef50_UPI0001926E0E PREDICTED: similar to hydroxymethylbilane... 369 e-101 UniRef50_C8WXM9 Porphobilinogen deaminase n=2 Tax=Alicyclobacill... 369 e-101 UniRef50_B3T8H9 Putative Porphobilinogen deaminase, dipyromethan... 369 e-100 UniRef50_A9A1A1 Probable porphobilinogen deaminase n=3 Tax=Thaum... 369 e-100 UniRef50_A8LIJ6 Porphobilinogen deaminase n=11 Tax=Alphaproteoba... 368 e-100 UniRef50_UPI00017922DC PREDICTED: similar to porphobilinogen dea... 368 e-100 UniRef50_C1CYD9 Porphobilinogen deaminase n=3 Tax=Deinococci Rep... 367 e-100 UniRef50_D1CBT4 Porphobilinogen deaminase n=1 Tax=Thermobaculum ... 367 e-100 UniRef50_C3WGN0 Porphobilinogen deaminase n=5 Tax=Fusobacterium ... 366 e-100 UniRef50_Q3YSA8 Porphobilinogen deaminase n=17 Tax=Rickettsiales... 365 e-100 UniRef50_B0K2L4 Porphobilinogen deaminase n=7 Tax=Bacteria RepID... 364 2e-99 UniRef50_UPI0000583C22 PREDICTED: hypothetical protein n=1 Tax=S... 363 4e-99 UniRef50_C3XEZ5 Porphobilinogen deaminase n=3 Tax=Campylobactera... 362 1e-98 UniRef50_Q5HBG1 Porphobilinogen deaminase n=2 Tax=Ehrlichia rumi... 360 3e-98 UniRef50_C6XGK7 Porphobilinogen deaminase n=1 Tax=Candidatus Lib... 359 6e-98 UniRef50_Q2S2A6 Porphobilinogen deaminase n=1 Tax=Salinibacter r... 359 1e-97 UniRef50_D0NJW2 Porphobilinogen deaminase n=2 Tax=Phytophthora i... 358 2e-97 UniRef50_Q4HT06 Porphobilinogen deaminase n=1 Tax=Campylobacter ... 357 3e-97 UniRef50_C7N5L0 Porphobilinogen deaminase n=2 Tax=Slackia RepID=... 357 3e-97 UniRef50_Q11XT5 Porphobilinogen deaminase n=8 Tax=Bacteria RepID... 354 2e-96 UniRef50_A6GB01 Porphobilinogen deaminase n=2 Tax=Bacteria RepID... 354 2e-96 UniRef50_A6DBT5 Porphobilinogen deaminase n=1 Tax=Caminibacter m... 354 2e-96 UniRef50_A8U3E9 Porphobilinogen deaminase n=1 Tax=alpha proteoba... 353 6e-96 UniRef50_B3U3W9 Hydroxymethylbilane synthetase n=1 Tax=Oxyrrhis ... 352 9e-96 UniRef50_A6GVP0 Hydroxymethylbilane synthase n=18 Tax=Bacteroide... 352 1e-95 UniRef50_C4Z552 Porphobilinogen deaminase n=8 Tax=Bacteria RepID... 350 2e-95 UniRef50_B2W5W6 Porphobilinogen deaminase n=2 Tax=Pleosporineae ... 350 2e-95 UniRef50_UPI00006CBE06 porphobilinogen deaminase family protein ... 350 4e-95 UniRef50_C6WZF5 Porphobilinogen deaminase n=1 Tax=Flavobacteriac... 350 4e-95 UniRef50_A9FDP9 Porphobilinogen deaminase n=1 Tax=Sorangium cell... 349 6e-95 UniRef50_A3CL78 Porphobilinogen deaminase n=1 Tax=Streptococcus ... 347 2e-94 UniRef50_Q1V167 Hydroxymethylbilane synthase n=3 Tax=Candidatus ... 347 3e-94 UniRef50_A0LRF1 Porphobilinogen deaminase n=1 Tax=Acidothermus c... 347 4e-94 UniRef50_A2Q9P7 Catalytic activity: 4 porphobilinogen+H(2)O<=>hy... 345 9e-94 UniRef50_C0YV01 Hydroxymethylbilane synthase n=1 Tax=Chryseobact... 344 2e-93 UniRef50_Q0TQG4 Porphobilinogen deaminase n=32 Tax=Clostridium R... 344 2e-93 UniRef50_C3PNS9 Porphobilinogen deaminase n=15 Tax=Rickettsia Re... 343 4e-93 UniRef50_C1AA38 Porphobilinogen deaminase n=1 Tax=Gemmatimonas a... 343 5e-93 UniRef50_A8MDU3 Probable porphobilinogen deaminase n=2 Tax=Therm... 343 5e-93 UniRef50_C1ZK04 Porphobilinogen deaminase n=1 Tax=Planctomyces l... 342 8e-93 UniRef50_A3ZKX4 Porphobilinogen deaminase n=1 Tax=Blastopirellul... 342 1e-92 UniRef50_C4ZFT9 Porphobilinogen deaminase n=1 Tax=Eubacterium re... 342 1e-92 UniRef50_A5CDH4 Porphobilinogen deaminase n=2 Tax=Orientia tsuts... 340 3e-92 UniRef50_B3DZQ6 Porphobilinogen deaminase n=1 Tax=Methylacidiphi... 339 7e-92 UniRef50_B8MVK7 Porphobilinogen deaminase, putative n=1 Tax=Tala... 339 7e-92 UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia... 339 8e-92 UniRef50_Q0BX92 Porphobilinogen deaminase n=1 Tax=Hyphomonas nep... 338 1e-91 UniRef50_A2BL26 Probable porphobilinogen deaminase n=2 Tax=Therm... 338 1e-91 UniRef50_B5G8F1 Porphobilinogen deaminase n=1 Tax=Streptomyces s... 336 5e-91 UniRef50_A4XK06 Porphobilinogen deaminase n=2 Tax=Clostridia Rep... 336 5e-91 UniRef50_C7NFP7 Hydroxymethylbilane synthase n=7 Tax=Actinomycet... 335 8e-91 UniRef50_Q09899 Porphobilinogen deaminase n=2 Tax=Schizosaccharo... 335 8e-91 UniRef50_C8WIZ2 Porphobilinogen deaminase n=2 Tax=Coriobacteriac... 334 3e-90 UniRef50_A8SQW4 Putative uncharacterized protein n=1 Tax=Coproco... 334 3e-90 UniRef50_A8MGE4 Porphobilinogen deaminase n=30 Tax=cellular orga... 333 4e-90 UniRef50_B9XN63 Porphobilinogen deaminase n=1 Tax=bacterium Elli... 332 7e-90 UniRef50_A4QB59 Porphobilinogen deaminase n=15 Tax=Corynebacteri... 332 9e-90 UniRef50_Q82P95 Porphobilinogen deaminase 2 n=14 Tax=Actinomycet... 332 1e-89 UniRef50_C1F251 Hydroxymethylbilane synthase n=1 Tax=Acidobacter... 332 1e-89 UniRef50_Q8TXC8 Probable porphobilinogen deaminase n=1 Tax=Metha... 332 1e-89 UniRef50_A0DD68 Chromosome undetermined scaffold_46, whole genom... 331 2e-89 UniRef50_B8GXG1 Porphobilinogen deaminase n=8 Tax=Caulobacterace... 331 2e-89 UniRef50_B0D5Q2 Predicted protein n=1 Tax=Laccaria bicolor S238N... 331 2e-89 UniRef50_D0J8N1 Porphobilinogen deaminase n=2 Tax=Blattabacteriu... 331 2e-89 UniRef50_C6XKH7 Porphobilinogen deaminase n=1 Tax=Hirschia balti... 330 3e-89 UniRef50_B6W7F3 Putative uncharacterized protein n=1 Tax=Anaeroc... 330 5e-89 UniRef50_Q7UPN0 Porphobilinogen deaminase n=1 Tax=Rhodopirellula... 330 5e-89 UniRef50_B2IAW6 Porphobilinogen deaminase n=4 Tax=Alphaproteobac... 328 1e-88 UniRef50_Q46CH0 Probable porphobilinogen deaminase n=7 Tax=Eurya... 328 2e-88 UniRef50_C4QMG7 Hydroxymethylbilane synthase (Porphobilinogen de... 327 3e-88 UniRef50_C5RMN3 Porphobilinogen deaminase n=1 Tax=Clostridium ce... 327 4e-88 UniRef50_O29026 Probable porphobilinogen deaminase n=1 Tax=Archa... 327 4e-88 UniRef50_D1BFI8 Hydroxymethylbilane synthase n=4 Tax=Actinomycet... 327 5e-88 UniRef50_C2FZW8 Porphobilinogen deaminase n=2 Tax=Sphingobacteri... 326 6e-88 UniRef50_A4CHM3 Porphobilinogen deaminase n=4 Tax=Bacteroidetes ... 325 1e-87 UniRef50_B3RTQ8 Putative uncharacterized protein n=1 Tax=Trichop... 325 1e-87 UniRef50_Q47LA7 Porphobilinogen deaminase n=3 Tax=Actinomycetale... 324 2e-87 UniRef50_C9M5W1 Hydroxymethylbilane synthase n=1 Tax=Jonquetella... 324 2e-87 UniRef50_Q4T5L1 Chromosome undetermined SCAF9206, whole genome s... 324 3e-87 UniRef50_A8AAB4 Probable porphobilinogen deaminase n=1 Tax=Ignic... 324 3e-87 UniRef50_D2RH82 Porphobilinogen deaminase n=2 Tax=Archaeoglobace... 323 4e-87 UniRef50_C6XST0 Porphobilinogen deaminase n=2 Tax=Pedobacter Rep... 323 4e-87 UniRef50_A3MLK5 Porphobilinogen deaminase n=155 Tax=Proteobacter... 323 6e-87 UniRef50_D2NS36 Porphobilinogen deaminase n=2 Tax=Micrococcaceae... 322 1e-86 UniRef50_C1TM53 Porphobilinogen deaminase n=1 Tax=Dethiosulfovib... 322 1e-86 UniRef50_UPI000174444E Hydroxymethylbilane synthase n=1 Tax=Verr... 322 1e-86 UniRef50_C2GGB5 Porphobilinogen deaminase n=2 Tax=Corynebacteriu... 322 1e-86 UniRef50_D1VCA1 Porphobilinogen deaminase n=1 Tax=Frankia sp. Eu... 321 2e-86 UniRef50_A4WN24 Probable porphobilinogen deaminase n=3 Tax=Therm... 321 2e-86 UniRef50_Q2NEP4 HemC n=4 Tax=Methanobacteriaceae RepID=Q2NEP4_METST 320 3e-86 UniRef50_Q9F7M2 Predicted porphobilinogen deaminase n=2 Tax=Bact... 320 4e-86 UniRef50_C6R3Y0 Hydroxymethylbilane synthase n=1 Tax=Rothia muci... 319 7e-86 UniRef50_A0QLI0 Porphobilinogen deaminase n=69 Tax=Actinomycetal... 318 2e-85 UniRef50_Q8D2W2 HemC protein n=1 Tax=Wigglesworthia glossinidia ... 318 2e-85 UniRef50_C0BZ93 Putative uncharacterized protein n=1 Tax=Clostri... 318 2e-85 UniRef50_Q57989 Probable porphobilinogen deaminase n=11 Tax=Meth... 317 4e-85 UniRef50_A1DGB8 Porphobilinogen deaminase n=1 Tax=Neosartorya fi... 316 5e-85 UniRef50_UPI0001BC2D4C glutamyl-tRNA reductase n=1 Tax=Brevibact... 316 8e-85 UniRef50_D1C4S0 Porphobilinogen deaminase n=1 Tax=Sphaerobacter ... 315 9e-85 UniRef50_O26960 Probable porphobilinogen deaminase n=1 Tax=Metha... 315 1e-84 UniRef50_Q1EPC8 Porphobilinogen deaminase, chloroplast (Hydroxym... 315 1e-84 UniRef50_C5CB88 Porphobilinogen deaminase n=5 Tax=Actinomycetale... 314 2e-84 UniRef50_B6JII8 Porphobilinogen deaminase n=11 Tax=Bradyrhizobia... 313 6e-84 UniRef50_C9RPT6 Porphobilinogen deaminase n=1 Tax=Fibrobacter su... 312 9e-84 UniRef50_Q6AHF1 Porphobilinogen deaminase n=5 Tax=Actinobacteria... 310 3e-83 UniRef50_A3VPD5 Porphobilinogen deaminase n=1 Tax=Parvularcula b... 308 1e-82 UniRef50_A8PWJ5 Putative uncharacterized protein n=1 Tax=Malasse... 308 1e-82 UniRef50_C5EV71 Pyruvate ferredoxin/flavodoxin oxidoreductase n=... 308 2e-82 UniRef50_B2ULP1 Porphobilinogen deaminase n=1 Tax=Akkermansia mu... 306 8e-82 UniRef50_A2SQU4 Uroporphyrin-III C-methyltransferase n=11 Tax=Eu... 305 1e-81 UniRef50_A6LKX0 Porphobilinogen deaminase n=1 Tax=Thermosipho me... 305 2e-81 UniRef50_Q6L2G8 Probable porphobilinogen deaminase n=1 Tax=Picro... 304 3e-81 UniRef50_C7DH16 Porphobilinogen deaminase n=1 Tax=Candidatus Mic... 303 5e-81 UniRef50_C6V4N6 Porphobilinogen deaminase n=2 Tax=Neorickettsia ... 303 5e-81 UniRef50_B3LB83 Porphobilinogen deaminase, putative n=1 Tax=Plas... 303 7e-81 UniRef50_D1B7N1 Porphobilinogen deaminase n=1 Tax=Thermanaerovib... 303 7e-81 UniRef50_Q5KKQ0 Hydroxymethylbilane synthase, putative n=2 Tax=F... 302 2e-80 UniRef50_Q0ATQ1 Porphobilinogen deaminase n=3 Tax=Alphaproteobac... 302 2e-80 UniRef50_B5GJG2 Porphobilinogen deaminase n=3 Tax=Streptomyces R... 300 3e-80 UniRef50_C7M2H5 Porphobilinogen deaminase n=1 Tax=Acidimicrobium... 300 5e-80 UniRef50_Q1AUK3 Porphobilinogen deaminase n=1 Tax=Rubrobacter xy... 299 8e-80 UniRef50_A4YD92 Probable porphobilinogen deaminase n=1 Tax=Metal... 298 2e-79 UniRef50_C7R376 Porphobilinogen deaminase n=1 Tax=Jonesia denitr... 298 2e-79 UniRef50_D1JID7 Porphobilinogen deaminase n=1 Tax=uncultured arc... 297 3e-79 UniRef50_C4JRY9 Porphobilinogen deaminase n=1 Tax=Uncinocarpus r... 296 8e-79 UniRef50_A9HK97 Porphobilinogen deaminase n=12 Tax=Acetobacterac... 295 1e-78 UniRef50_B5JN62 Porphobilinogen deaminase n=1 Tax=Verrucomicrobi... 295 1e-78 UniRef50_Q2FTK7 Hydroxymethylbilane synthase n=3 Tax=Methanomicr... 293 4e-78 UniRef50_C3MZR8 Probable porphobilinogen deaminase n=11 Tax=Sulf... 293 5e-78 UniRef50_D2RNT2 Porphobilinogen deaminase n=1 Tax=Acidaminococcu... 292 8e-78 UniRef50_C0W553 Porphobilinogen deaminase n=2 Tax=Actinomycetale... 291 2e-77 UniRef50_Q4PFH9 Putative uncharacterized protein n=1 Tax=Ustilag... 291 3e-77 UniRef50_C8WDJ7 Porphobilinogen deaminase n=3 Tax=Zymomonas mobi... 285 1e-75 UniRef50_Q97B26 Probable porphobilinogen deaminase n=2 Tax=Therm... 284 3e-75 UniRef50_A2BFN7 Hydroxymethylbilane synthase (Fragment) n=6 Tax=... 283 4e-75 UniRef50_C1XV35 Porphobilinogen deaminase n=2 Tax=Meiothermus Re... 283 5e-75 UniRef50_C5C5B3 Porphobilinogen deaminase n=6 Tax=Actinomycetale... 282 1e-74 UniRef50_Q8I5V3 Porphobilinogen deaminase n=6 Tax=Plasmodium Rep... 281 2e-74 UniRef50_B4D5X7 Porphobilinogen deaminase n=1 Tax=Chthoniobacter... 281 2e-74 UniRef50_B0WMK9 Porphobilinogen deaminase n=1 Tax=Culex quinquef... 281 3e-74 UniRef50_Q93A65 Porphobilinogen deaminase n=1 Tax=uncultured bac... 280 4e-74 UniRef50_Q9Y9J0 Probable porphobilinogen deaminase n=1 Tax=Aerop... 280 4e-74 UniRef50_Q0RS16 Porphobilinogen deaminase 1 (PBG 1) (Hydroxymeth... 278 1e-73 UniRef50_Q1GP41 Porphobilinogen deaminase n=7 Tax=Sphingomonadal... 274 2e-72 UniRef50_Q83H95 Porphobilinogen deaminase n=2 Tax=Tropheryma whi... 271 3e-71 UniRef50_UPI000038E213 porphobilinogen deaminase n=1 Tax=Ferropl... 270 7e-71 UniRef50_A9V9E0 Predicted protein n=1 Tax=Monosiga brevicollis R... 268 2e-70 UniRef50_UPI0001C31A39 porphobilinogen deaminase n=1 Tax=Conexib... 262 1e-68 UniRef50_Q04X38 Bifunctional porphobilinogen deaminase/uroporphy... 262 1e-68 UniRef50_B0SF66 Bifunctional porphobilinogen deaminase/uroporphy... 261 2e-68 UniRef50_A7BMK1 Porphobilinogen deaminase n=1 Tax=Beggiatoa sp. ... 261 2e-68 UniRef50_A5K0J5 Porphobilinogen deaminase, putative n=1 Tax=Plas... 258 1e-67 UniRef50_B1ZV87 Porphobilinogen deaminase n=2 Tax=Opitutaceae Re... 254 4e-66 UniRef50_Q86ET2 Clone ZZD1450 mRNA sequence n=3 Tax=Schistosoma ... 243 7e-63 UniRef50_C0EAN0 Putative uncharacterized protein n=1 Tax=Clostri... 237 4e-61 UniRef50_Q6MHU0 Hydroxymethylbilane synthase n=1 Tax=Bdellovibri... 235 1e-60 UniRef50_Q4E9D5 Porphobilinogen deaminase (Fragment) n=1 Tax=Wol... 233 8e-60 UniRef50_B6YQR9 Hydroxymethylbilane synthase/uroporphyrin-III C-... 225 2e-57 UniRef50_Q6MEK3 Putative Porphobilinogen deaminase n=2 Tax=Parac... 224 3e-57 UniRef50_B4UXX3 Porphobilinogen deaminase 2 (Fragment) n=1 Tax=S... 223 8e-57 UniRef50_A8I2X7 Porphobilinogen deaminase n=1 Tax=Chlamydomonas ... 218 1e-55 UniRef50_Q6Q923 Predicted porphobilinogen deaminase n=2 Tax=envi... 210 5e-53 UniRef50_Q9PK95 Probable porphobilinogen deaminase n=13 Tax=Chla... 207 3e-52 UniRef50_D0RNS6 Putative porphobilinogen deaminase (Pbg)(Hydroxy... 203 6e-51 UniRef50_C5LJF7 Porphobilinogen deaminase, putative n=5 Tax=Perk... 200 4e-50 UniRef50_Q9HMY5 Probable porphobilinogen deaminase n=2 Tax=Halob... 196 1e-48 UniRef50_Q18ES3 Hydroxymethylbilane synthase (Porphobilinogen de... 181 2e-44 UniRef50_UPI000155526F PREDICTED: similar to hydroxymethylbilane... 166 1e-39 UniRef50_B0KCR7 Porphobilinogen deaminase n=3 Tax=Thermoanaeroba... 161 3e-38 UniRef50_C0DZX9 Putative uncharacterized protein n=1 Tax=Coryneb... 154 3e-36 UniRef50_UPI0001B4213A porphobilinogen deaminase n=1 Tax=Listeri... 144 3e-33 UniRef50_A8CBG6 Porphobilinogen deaminase n=3 Tax=Toxoplasma gon... 143 8e-33 UniRef50_UPI0001742E92 Porphobilinogen deaminase n=1 Tax=candida... 133 1e-29 UniRef50_C4Z1K5 Putative uncharacterized protein n=1 Tax=Eubacte... 126 1e-27 UniRef50_Q401C3 Hydroxymethylbilane synthase (Fragment) n=7 Tax=... 124 6e-27 UniRef50_UPI0001698669 porphobilinogen deaminase n=1 Tax=Endorif... 120 5e-26 UniRef50_Q1HRH6 Hydroxymethylbilane synthase-like protein n=1 Ta... 118 2e-25 UniRef50_C5G109 Porphobilinogen deaminase n=1 Tax=Microsporum ca... 112 2e-23 UniRef50_B8N6H4 Putative uncharacterized protein n=1 Tax=Aspergi... 100 6e-20 UniRef50_UPI0000D9FBB5 PREDICTED: similar to lethal (3) 02640 CG... 100 1e-19 UniRef50_UPI0001C35DE1 porphobilinogen deaminase n=1 Tax=Clostri... 89 2e-16 UniRef50_C5U771 Porphobilinogen deaminase n=1 Tax=Methanocaldoco... 74 9e-12 UniRef50_Q4EB45 Porphobilinogen deaminase n=1 Tax=Wolbachia endo... 63 1e-08 UniRef50_B5XH53 Porphobilinogen deaminase n=1 Tax=Salmo salar Re... 60 1e-07 UniRef50_C2BR76 Putative uncharacterized protein (Fragment) n=1 ... 59 2e-07 UniRef50_UPI0000D537E6 hypothetical protein P700755_22735 n=1 Ta... 55 3e-06 >UniRef50_B7LU53 Porphobilinogen deaminase n=87 Tax=cellular organisms RepID=HEM3_ESCF3 Length = 313 Score = 447 bits (1151), Expect = e-124, Method: Composition-based stats. Identities = 296/312 (94%), Positives = 302/312 (96%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 MLDNVLRIATRQSPLALWQAHYVKD LMA HPGL VELVPMVTRGDVILDTPLAKVGGKG Sbjct: 1 MLDNVLRIATRQSPLALWQAHYVKDALMAKHPGLTVELVPMVTRGDVILDTPLAKVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN Y SLD LP Sbjct: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNKYASLDELP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE Sbjct: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 SRIR ALPPE+SLPAVGQGAVGIECRLDD+RTRELLAALNH ETALRVTAERAMNTRLEG Sbjct: 181 SRIRDALPPEVSLPAVGQGAVGIECRLDDTRTRELLAALNHPETALRVTAERAMNTRLEG 240 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPIGSYAELI GEIWLRALVGAPDGSQ+IRGERRG+PQDAE+MGISLAEELLNNGAR Sbjct: 241 GCQVPIGSYAELIGGEIWLRALVGAPDGSQMIRGERRGSPQDAEKMGISLAEELLNNGAR 300 Query: 301 EILAEVYNGDAP 312 ILA+VYNGDAP Sbjct: 301 AILADVYNGDAP 312 >UniRef50_B5FN93 Porphobilinogen deaminase n=168 Tax=cellular organisms RepID=HEM3_SALDC Length = 313 Score = 440 bits (1133), Expect = e-122, Method: Composition-based stats. Identities = 279/313 (89%), Positives = 294/313 (93%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 MLDNVLRIATRQSPLALWQAHYVKD LMA+HPGL VELVPMVTRGDVILDTPLAKVGGKG Sbjct: 1 MLDNVLRIATRQSPLALWQAHYVKDALMATHPGLTVELVPMVTRGDVILDTPLAKVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKELE+ALLE RADIAVHSMKDVPV FP GLGLVTICEREDPRDAFVSN Y SLD LP Sbjct: 61 LFVKELEIALLEKRADIAVHSMKDVPVAFPDGLGLVTICEREDPRDAFVSNKYHSLDDLP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRL KLDNG+YDAIILAVAGLKRLGLE Sbjct: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLGKLDNGDYDAIILAVAGLKRLGLE 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 SRIR ALPP++SLPAVGQGAVGIECRLDD+RT+ LLA LNH +TALRVTAERAMNTRLEG Sbjct: 181 SRIRTALPPDVSLPAVGQGAVGIECRLDDARTQALLAPLNHSQTALRVTAERAMNTRLEG 240 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPIGSYAE+I+GEIWLRALVGAPDGS ++RGERRG+P+ AEQMGISLAEELL NGAR Sbjct: 241 GCQVPIGSYAEIINGEIWLRALVGAPDGSVMVRGERRGSPEQAEQMGISLAEELLENGAR 300 Query: 301 EILAEVYNGDAPA 313 IL EVYNG+ PA Sbjct: 301 AILTEVYNGETPA 313 >UniRef50_Q3ACT3 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=HEM3_CARHZ Length = 311 Score = 436 bits (1123), Expect = e-121, Method: Composition-based stats. Identities = 146/310 (47%), Positives = 202/310 (65%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + + + +R S LALWQ ++V ++L HP + ++V M T+GD ILD LAK+G KGL Sbjct: 1 MKKEVIVGSRDSALALWQTNWVVERLSKIHPEINFKIVTMKTKGDKILDVALAKIGDKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F KELE ALL D+AVHSMKD+P P+GL + CERE P D F+S LP Sbjct: 61 FTKELEHALLNKTIDMAVHSMKDLPTVLPEGLKIGAFCEREYPGDVFISPKGFKFLELPQ 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ +GTSSLRR Q+ RPDL LRGN+ TR K++ + D IILA AG+KRLG E Sbjct: 121 GARIGTSSLRRIAQILAVRPDLQAIPLRGNLPTRFRKMEEMDLDGIILAYAGVKRLGYED 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 +I L ++ LPAVGQG++G+E R DD+ ELL ++H T + AERA RLEGG Sbjct: 181 KITEMLSFDLCLPAVGQGSIGVEIRADDTFIEELLKPIDHFATNRAIRAERAFLKRLEGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 CQ+PIG+Y+E+ + + L+ +V + DG +I+GE+ G+ ++ E++GISLAEELL GA++ Sbjct: 241 CQIPIGAYSEVKENRLHLKGVVASLDGKLVIKGEKEGSIEEPEKVGISLAEELLTKGAQK 300 Query: 302 ILAEVYNGDA 311 IL E+ Sbjct: 301 ILEEIRRDAN 310 >UniRef50_C0QU69 Porphobilinogen deaminase n=4 Tax=Bacteria RepID=C0QU69_PERMH Length = 308 Score = 435 bits (1119), Expect = e-120, Method: Composition-based stats. Identities = 171/306 (55%), Positives = 229/306 (74%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR+S LALWQA+Y+ D+L P L VELV +VT+GD ILD PLAKVGGKGLFVKE Sbjct: 3 IRIGTRKSKLALWQANYIADQLKKHFPDLEVELVKIVTKGDKILDVPLAKVGGKGLFVKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E A+L N DIAVHS+KDVP FP+GLGLV I EREDPRDAF+S Y+S++ +P G+++ Sbjct: 63 IEEAMLRNEIDIAVHSLKDVPTYFPEGLGLVAITEREDPRDAFLSVKYNSIEDMPEGAVL 122 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR+ Q+ +R D+ I LRGNV TR+ KL+ G+YD IILA AGLKRLGLE ++R Sbjct: 123 GTSSLRRKAQIMMKRKDIRIEDLRGNVDTRIRKLEEGQYDGIILAYAGLKRLGLEGKVRQ 182 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L P+ +PAV QG +GIE RLDD +TRE+++ LNH E+ +R AERA LEGGCQVP Sbjct: 183 ILQPDYMIPAVAQGFLGIEARLDDEKTREIVSVLNHRESEIRAKAERAFLKTLEGGCQVP 242 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 + Y+E+++G++ + V G ++ R G+ +DAE +G+ LAE+LL++GA+E+L E Sbjct: 243 LAGYSEIVNGKLKITGFVSDLTGDRVFRDSMEGSLEDAESLGVKLAEKLLSDGAKEVLEE 302 Query: 306 VYNGDA 311 +Y+G Sbjct: 303 IYSGSE 308 >UniRef50_B5YJZ4 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=B5YJZ4_THEYD Length = 311 Score = 429 bits (1104), Expect = e-119, Method: Composition-based stats. Identities = 157/309 (50%), Positives = 219/309 (70%), Gaps = 1/309 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 + N + I +R S LA+WQA++VKDKL +P L VE+ + T GD ILD PLAK+GGKG Sbjct: 3 VKRNKIVIGSRGSKLAMWQANWVKDKLQTLYPELKVEIEKIKTTGDKILDAPLAKIGGKG 62 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E ALL R D+AVHSMKDVP E P+GL + ICEREDPRDAF+S + L+ LP Sbjct: 63 LFVKEIEEALLSKRVDLAVHSMKDVPTEIPEGLQISAICEREDPRDAFISKDGVLLNELP 122 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 +++GTSSLRR QL R DL+I+ LRGNV TR+ KL +GE+ AI+LA+AG+KR+G+E Sbjct: 123 QEAVLGTSSLRRTVQLKALRNDLVIKPLRGNVDTRIRKLKDGEFQAIVLAMAGVKRMGVE 182 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 + + A ++ +PA+GQGA+GIE R+DD EL+ LNH ETA+ + AERA + + G Sbjct: 183 NLVTQAFSEDLMIPAIGQGAIGIETRVDDDFVNELIKPLNHEETAICILAERAFLSVMGG 242 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQ-IIRGERRGAPQDAEQMGISLAEELLNNGA 299 GCQVP+ +A +++ + + ++G P+G +I+G R G+ A+ +G+ LA ELL+ G Sbjct: 243 GCQVPLACHARIVNNSLKIVGMIGDPEGKMPVIKGFREGSLSQAQSLGVELANELLHRGG 302 Query: 300 REILAEVYN 308 +EIL +VY Sbjct: 303 KEILEKVYK 311 >UniRef50_C0Q9U2 HemC n=2 Tax=Bacteria RepID=C0Q9U2_DESAH Length = 325 Score = 428 bits (1101), Expect = e-118, Method: Composition-based stats. Identities = 146/307 (47%), Positives = 199/307 (64%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + ++I TR S LALWQA++VKD++ P VE++ + T GD+I+D PL+ VGGKGL Sbjct: 19 MKKTIKIGTRGSKLALWQANHVKDRIEDQFPETEVEIMTIKTTGDMIVDRPLSMVGGKGL 78 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKE+E ALLE+ D+AVHSMKD+P E P GL + + RE+P D +SNN SL LP Sbjct: 79 FVKEIEKALLESTIDMAVHSMKDMPGELPPGLVIGAVPARENPFDVLISNNNLSLADLPK 138 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ +GTSSLRR Q+ RPD+ S+RGN+ TRL KL GE+DA +LA AGL RLG+++ Sbjct: 139 GARIGTSSLRRASQIKHARPDIETASIRGNLDTRLKKLAAGEFDATLLAAAGLIRLGMKT 198 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 I I +PAVGQGA+ IE R +D +LA LNH ET V+ ERA RL+G Sbjct: 199 VITQYFDETIMIPAVGQGALCIESRQEDLDIAPVLAFLNHGETHTVVSGERAFLRRLDGS 258 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 C +P+ + L D + L LV + DG I++ G P+D ++ GI+LAE LL+ GA + Sbjct: 259 CHIPVACFGRLEDHRVILTGLVASEDGRTILKETVAGTPEDPQKAGIALAETLLSKGADK 318 Query: 302 ILAEVYN 308 IL + + Sbjct: 319 ILENLNS 325 >UniRef50_Q8YVU6 Porphobilinogen deaminase n=50 Tax=cellular organisms RepID=HEM3_ANASP Length = 323 Score = 423 bits (1088), Expect = e-117, Method: Composition-based stats. Identities = 151/308 (49%), Positives = 199/308 (64%), Gaps = 3/308 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +RI +R+S LAL Q ++V+++L S P + E+ M T+GD ILD LAK+G KGLF Sbjct: 10 RTIRIGSRKSQLALVQTYWVREQLQNSFPDINFEVHTMSTQGDKILDVALAKIGDKGLFT 69 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALP 120 KELEV ++ D AVHS+KD+P P+GL L I ERE+P DA V + +D LP Sbjct: 70 KELEVGMINEEIDFAVHSLKDLPTNLPEGLALAAITERENPADALVVHENFKDKQIDTLP 129 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 AG+++GTSSLRR QL + P L + +RGN+ TRL+KLD GEYD +ILA AGL+RLG+ Sbjct: 130 AGAVIGTSSLRRLAQLRNQFPHLTFKDVRGNLNTRLAKLDAGEYDGLILAAAGLQRLGMG 189 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R+ LP EISL AVGQGA+GIECR DD+ +L A+ H ET R AER+ LEG Sbjct: 190 DRVHQILPKEISLHAVGQGALGIECRADDAELITVLKAIEHPETRDRCLAERSFLRSLEG 249 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPIG E+ E+ L +V + DG +++ G DAE +GI LAE L GA+ Sbjct: 250 GCQVPIGVNTEINGNELILTGVVASVDGQNLVKDTVSGNASDAEAIGIRLAELLREQGAQ 309 Query: 301 EILAEVYN 308 EIL ++ Sbjct: 310 EILNTIFA 317 >UniRef50_D1BNZ5 Porphobilinogen deaminase n=3 Tax=Veillonella RepID=D1BNZ5_VEIPT Length = 312 Score = 422 bits (1087), Expect = e-117, Method: Composition-based stats. Identities = 144/309 (46%), Positives = 195/309 (63%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + + +RI TR+S LALWQA ++ +L +P + VELV T+GD IL+ PLA+VGGKGL Sbjct: 1 MRDHIRIGTRKSALALWQAEHISAELQRLYPNITVELVHFNTKGDRILEKPLAQVGGKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F ELE A+ DIAVHS+KD+P E P+GL L I RE P DA VS Y +LD LP Sbjct: 61 FTAELEEAMHAGDIDIAVHSLKDMPTELPEGLTLGAISAREVPYDALVSPVYKTLDKLPQ 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ VGTSSLRRQ QL RPDL + +RGNV TRLSK++ + D +ILA AGLKRLGLE Sbjct: 121 GARVGTSSLRRQAQLLHVRPDLKVEVIRGNVQTRLSKIETEKLDGVILAQAGLKRLGLED 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 +I + +PAVGQGA+ IECR DD+ ++L +N T V ER+ +L GG Sbjct: 181 QITQVFKADEMIPAVGQGALAIECRADDTEMLDMLDPINDEATRYAVEGERSFLRQLNGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 CQVP+G + + G++ L+A++ + DG + GE G + E +G +LA+ L G + Sbjct: 241 CQVPMGVHGTINKGQLTLKAMIASLDGKTVYEGEISGPAKKGEILGKNLAKALYEEGGKR 300 Query: 302 ILAEVYNGD 310 I+ + Sbjct: 301 IVDALIEEG 309 >UniRef50_Q8DIE4 Porphobilinogen deaminase n=11 Tax=cellular organisms RepID=HEM3_THEEB Length = 320 Score = 419 bits (1077), Expect = e-116, Method: Composition-based stats. Identities = 151/314 (48%), Positives = 199/314 (63%), Gaps = 3/314 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 +RI +R+S LAL Q +V+ +L H E+V M T+GD ILD LAK+G KGL Sbjct: 5 SSRPVRIGSRKSQLALVQTEWVQAQLQTHHRDRAFEVVTMTTQGDNILDVALAKIGDKGL 64 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDA 118 F KELE+++L D+AVHS+KD+P + P GL L I EREDP DA V ++D Sbjct: 65 FTKELELSMLRGETDLAVHSLKDLPTQLPDGLVLAAITEREDPADALVLGAKWTGHTIDT 124 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 LP G+++GTSSLRR QL P L + +RGN+ TRL+KLD GEYDA+ILAVAGL+RLG Sbjct: 125 LPEGTVIGTSSLRRLAQLRHYYPHLTFKDVRGNLNTRLAKLDAGEYDALILAVAGLRRLG 184 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 RI LP +SL AVGQGA+GIECR +D+ L+ L H ET R AERA +L Sbjct: 185 FGDRISQVLPATVSLYAVGQGALGIECRAEDADILALVKTLEHPETTARCLAERAFLRQL 244 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 EGGCQVPIG + + +G++ L LV + DG ++++ G AE++G LA +L G Sbjct: 245 EGGCQVPIGVHTVIENGQLTLTGLVASLDGQRLVKDSLTGDVATAEELGTRLALKLREQG 304 Query: 299 AREILAEVYNGDAP 312 A EIL E++ P Sbjct: 305 ASEILEEIFATVRP 318 >UniRef50_Q0I178 Porphobilinogen deaminase n=45 Tax=Bacteria RepID=HEM3_HAES1 Length = 321 Score = 415 bits (1068), Expect = e-115, Method: Composition-based stats. Identities = 199/317 (62%), Positives = 235/317 (74%), Gaps = 11/317 (3%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + L+IATRQSPLALWQA+YVK++L + L VELVP++T+GDVILDTPLAK+GGKGLF Sbjct: 4 NKTLKIATRQSPLALWQANYVKNRLQQRYSHLSVELVPIITKGDVILDTPLAKIGGKGLF 63 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 VKELE ALL ADIAVHSMKDVP++FP+GL L IC REDPRDAFVSN Y +LD LP G Sbjct: 64 VKELENALLNGEADIAVHSMKDVPMQFPKGLELSVICPREDPRDAFVSNKYRTLDELPQG 123 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 +IVGTSSLRRQCQL R DL IRSLRGNVGTRL+KLD G+YDAIILA AGL RLGL R Sbjct: 124 AIVGTSSLRRQCQLKNWRADLDIRSLRGNVGTRLNKLDQGDYDAIILASAGLIRLGLTER 183 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 IR+ + + LPA GQGAVGIECR+DD + LL L T V AERAMN L+GGC Sbjct: 184 IRSFIEIDTILPACGQGAVGIECRVDDRDVQSLLMPLADQTTTYCVLAERAMNFHLQGGC 243 Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE-----------RRGAPQDAEQMGISLA 291 QVPIG+YA L + +++LR LVG GSQI+ E + A Q AE++G+S+A Sbjct: 244 QVPIGAYAILENNQLYLRGLVGDVHGSQILSAEGQFELSLDFESSQSAVQKAEELGVSIA 303 Query: 292 EELLNNGAREILAEVYN 308 E+LL GA +IL VY Sbjct: 304 EQLLQQGADKILQAVYQ 320 >UniRef50_Q65GK1 Porphobilinogen deaminase n=98 Tax=Bacillales RepID=HEM3_BACLD Length = 313 Score = 414 bits (1066), Expect = e-114, Method: Composition-based stats. Identities = 143/307 (46%), Positives = 188/307 (61%), Gaps = 4/307 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 + + +R+S LA+ Q +V KL +P E+ +VT+GD ILD L+KVGGKGLFV Sbjct: 2 RNIIVGSRRSKLAMTQTKWVIKKLEELNPDFTFEIKEIVTKGDRILDVTLSKVGGKGLFV 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE+E A+L D+AVHSMKD+P P+GL + I +RED RD +S L L G+ Sbjct: 62 KEIEQAMLSGEIDMAVHSMKDMPSVLPEGLMVGCIPKREDARDVLISKGRQKLADLKQGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL-ESR 182 +VGTSSLRR QL + RPDL I+ +RGN+ TRL KL+ +YDAIILA AGL R+G + Sbjct: 122 VVGTSSLRRSAQLLQMRPDLEIKWIRGNIDTRLKKLETEDYDAIILAAAGLSRMGWKDDV 181 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 + L PE LPAVGQGA+ IECR D L + LN T L VTAERA +EGGC Sbjct: 182 VTEFLDPESCLPAVGQGALAIECRGSDEELLSLFSRLNDRYTQLTVTAERAFLHAMEGGC 241 Query: 243 QVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 QVPI +A++ DG I L LV +PDG + R +G +D E +G A + GA+ Sbjct: 242 QVPIAGFAKMDEDGVIELTGLVASPDGKTVYRETVKG--KDPEAVGRECAAVMSEKGAKA 299 Query: 302 ILAEVYN 308 ++ V Sbjct: 300 LIDRVKQ 306 >UniRef50_A1AUE7 Porphobilinogen deaminase n=44 Tax=Bacteria RepID=HEM3_PELPD Length = 310 Score = 413 bits (1062), Expect = e-114, Method: Composition-based stats. Identities = 167/310 (53%), Positives = 204/310 (65%), Gaps = 1/310 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M LRI TR S LALWQA++VK +L +P + V L + T GD ILD PLA+VGGKG Sbjct: 1 MPPRQLRIGTRASQLALWQANWVKSELEKRYPAMEVTLTKIKTMGDRILDVPLAQVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E A+L DIAVHSMKDVP EFP+GLGL I EREDPRDA VS LP Sbjct: 61 LFVKEIEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVVSR-AARFSHLP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGTS+LRRQ QL RPDL + ++RGNV TR+ KLD DA+ILA AGLKRLGL Sbjct: 120 PGARVGTSALRRQAQLLHARPDLEMVTIRGNVETRIRKLDEENLDAVILAAAGLKRLGLT 179 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R+ L E S+PA+GQGA+GIECRL D E +A NH +T+ V AERA+ R +G Sbjct: 180 QRVAEYLDVEFSIPAIGQGALGIECRLSDPVVTEAIAFFNHPDTSHAVRAERALLRRCQG 239 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPI ++ + GE+ L L+ A DG + +R E G E +G LA+ LL+ G R Sbjct: 240 GCQVPIAAHGTIRGGELRLVGLIAAVDGREFVRDEISGPVDQCEHLGEELADRLLSRGGR 299 Query: 301 EILAEVYNGD 310 IL EVY + Sbjct: 300 AILEEVYQRE 309 >UniRef50_B5EBG8 Porphobilinogen deaminase n=166 Tax=Bacteria RepID=HEM3_GEOBB Length = 318 Score = 411 bits (1058), Expect = e-113, Method: Composition-based stats. Identities = 158/310 (50%), Positives = 205/310 (66%), Gaps = 1/310 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M LRI TR S LALWQA++VK +L +P + V L + T GD ILD PLA+VGGKG Sbjct: 1 MALKELRIGTRASQLALWQANWVKSELEKRYPDMTVTLTKIKTIGDKILDVPLAQVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E A+L DIAVHSMKDVP EFP+GLGL I EREDPRDA +SN LP Sbjct: 61 LFVKEIEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVISN-GVKFADLP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GTS+LRRQ QL + RPDL + +RGNV TR+ KL DA+ILA AGL RLG Sbjct: 120 QGARIGTSALRRQAQLLKVRPDLEMVIIRGNVQTRMDKLKTEGLDAVILAAAGLNRLGFA 179 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 +I LP ++SLPA+GQGA+GIEC L + ++ ++ N +T+ V AERA+ R EG Sbjct: 180 DQITEMLPTDLSLPAIGQGALGIECNLSNQDVKDAISFFNSPDTSRAVRAERALLWRCEG 239 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPI ++ E+ ++ L + + DG ++G G D E++G+ LAE+LL+ G Sbjct: 240 GCQVPIAAFGEVTGDQLKLTGFIASVDGKVSVKGVVTGPADDCEKLGVKLAEQLLSEGGH 299 Query: 301 EILAEVYNGD 310 ILAEVY + Sbjct: 300 AILAEVYQRE 309 >UniRef50_A6TJD5 Porphobilinogen deaminase n=2 Tax=Firmicutes RepID=HEM3_ALKMQ Length = 316 Score = 410 bits (1054), Expect = e-113, Method: Composition-based stats. Identities = 139/308 (45%), Positives = 191/308 (62%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 ++I +R S LAL QA + + L P E++ + T GD ILD L K+GGKGLFV Sbjct: 2 RTIKIGSRASQLALVQAEIIINMLKEKFPQYTYEIIKITTLGDRILDKTLDKIGGKGLFV 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE++ AL E + D+A+HSMKD+P E P+ L L I +REDPRD ++ SL+ LP G+ Sbjct: 62 KEIQKALAEEKIDLAIHSMKDMPGETPEELVLGAITKREDPRDVLITRENKSLEELPKGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 ++G+SSLRRQ Q+ R D+ + +RGNVGTRL K++ D +ILA AGL RLGL+ +I Sbjct: 122 VIGSSSLRRQAQVMALRGDIKVVPIRGNVGTRLGKIETESLDGVILAAAGLNRLGLKEKI 181 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + L E PAVGQGA+G E R D E+L A+NH ET V AERA LEGGC Sbjct: 182 SSYLEIEDFTPAVGQGALGCEARRKDIEMLEMLLAINHEETYRCVMAERAFLKLLEGGCH 241 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 VPIG+Y + E+ + +V + DG ++I+ + G D + +GI L E L+ GA+EIL Sbjct: 242 VPIGAYGQQQGQELHMTGMVASSDGRRVIKEQVMGDIADFQALGIQLGETLIEKGAKEIL 301 Query: 304 AEVYNGDA 311 V + Sbjct: 302 ETVNTDNR 309 >UniRef50_C9KL85 Hydroxymethylbilane synthase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KL85_9FIRM Length = 315 Score = 409 bits (1051), Expect = e-113, Method: Composition-based stats. Identities = 162/307 (52%), Positives = 201/307 (65%), Gaps = 1/307 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M ++ + I TR S LALWQA YV D L +P L VE M T+GD ILD PLAK+GGKG Sbjct: 1 MKNDTIVIGTRSSKLALWQADYVADCLRKRYPELRVEKKLMTTKGDKILDAPLAKIGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF KELE +L DIAVHS+KD+P E P+GL + I ER DP DA VS Y +L+ LP Sbjct: 61 LFTKELEQDMLAGGIDIAVHSLKDMPTEVPEGLVISAITERFDPGDAVVSPKYRTLENLP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGTSSLRR+ QL RPDL I LRGNV TRL KL+ +DAIILAVAGLKRLG Sbjct: 121 QGAKVGTSSLRRKAQLLHARPDLQISDLRGNVNTRLEKLEREHFDAIILAVAGLKRLGFA 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 RI LP E+ LPAVGQGA+ IE R +D R L+A LN T AERA R+EG Sbjct: 181 DRITEVLPREMVLPAVGQGALAIETRENDREVRNLIAFLNDEATVACARAERAFLARVEG 240 Query: 241 GCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GCQVP+G YA +G + + A++ + DG+++ R G+ +AE +G +LA++LL G Sbjct: 241 GCQVPVGVYAVPEAEGRLHVEAVIASLDGARLYRDAAVGSAAEAESLGTALADKLLAMGG 300 Query: 300 REILAEV 306 IL E+ Sbjct: 301 IAILHEI 307 >UniRef50_Q31PM2 Porphobilinogen deaminase n=8 Tax=cellular organisms RepID=HEM3_SYNE7 Length = 320 Score = 406 bits (1045), Expect = e-112, Method: Composition-based stats. Identities = 151/312 (48%), Positives = 200/312 (64%), Gaps = 3/312 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +RI +R+S LAL Q H+V+ +L +P ++ M T+GD+ILD LAK+G KGLF Sbjct: 7 RPIRIGSRKSQLALVQTHWVQGELQRLYPDRQFDVQTMSTQGDIILDVALAKIGDKGLFT 66 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALP 120 KELEVA+L D AVHS+KD+P P+GL L + EREDP DA V + L+ LP Sbjct: 67 KELEVAMLAGEVDFAVHSLKDLPTRLPEGLILGCVTEREDPADALVVHDRFKDHQLETLP 126 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+++GTSSLRR QL P L + +RGN+ TRL+KLD GEYDA+ILA AGL+RL + Sbjct: 127 EGTVIGTSSLRRLAQLRHHYPHLQFKDVRGNLNTRLAKLDAGEYDALILAAAGLQRLSMA 186 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 RI +P +SL AVGQGA+GIECR +D ELL AL H T+ R AERA LEG Sbjct: 187 DRIHQLIPAAVSLHAVGQGALGIECRAEDPEILELLKALEHEPTSQRCLAERAFLRELEG 246 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPIG + DG + L +V + DG +++R + G D E +G++LA +L GA+ Sbjct: 247 GCQVPIGVNTAIADGTLTLTGMVASLDGQRLLRDQVSGPTSDPEALGLALAAQLKAQGAK 306 Query: 301 EILAEVYNGDAP 312 EIL E++ P Sbjct: 307 EILDEIFATVRP 318 >UniRef50_C6HUG2 Porphobilinogen deaminase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HUG2_9BACT Length = 321 Score = 402 bits (1033), Expect = e-110, Method: Composition-based stats. Identities = 156/305 (51%), Positives = 205/305 (67%), Gaps = 2/305 (0%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + +RI TR S LALWQA +V + GL EL + T GD+IL PL++VGGKGLF Sbjct: 7 SSPIRIGTRGSELALWQARHVAAMIR-HTAGLESELTIIKTTGDMILSVPLSQVGGKGLF 65 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 VKE+E AL+ D+AVHSMKDVP P+GL + I REDPRDAFVSN Y S +LP G Sbjct: 66 VKEIEEALIAGTIDLAVHSMKDVPAFLPEGLEIGAILSREDPRDAFVSNAYSSFSSLPPG 125 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 + +GTSSLRR QL +RRPDL SLRGNVGTRL KLD + DAIILA AGL RLG R Sbjct: 126 ARIGTSSLRRMAQLKKRRPDLRFESLRGNVGTRLRKLDENQIDAIILAAAGLIRLGFSDR 185 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 IR LP E+SLPAVGQGA+G+ECR D R R +LA ++ ET V AER + + L+GGC Sbjct: 186 IREYLPVELSLPAVGQGALGLECRTGDHRIRTILARMHDPETTACVLAERGVLSALDGGC 245 Query: 243 QVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 Q+PI ++A + +I L A + +G+ ++ G ++A ++G+ A++LL+ G ++ Sbjct: 246 QLPIAAHARTISPEQIELIARILDVEGTTLLEEHTSGPAKEAHRLGVEAAQKLLSRGGQK 305 Query: 302 ILAEV 306 IL ++ Sbjct: 306 ILTDI 310 >UniRef50_Q5ZRY6 Porphobilinogen deaminase n=6 Tax=Legionella RepID=HEM3_LEGPH Length = 309 Score = 399 bits (1025), Expect = e-110, Method: Composition-based stats. Identities = 153/309 (49%), Positives = 205/309 (66%), Gaps = 1/309 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M ++RIATRQSPLALWQA++V++ L+ P L +EL+PM+T GD L L GGKG Sbjct: 1 MSAKIIRIATRQSPLALWQANHVREMLVKQWPNLSIELLPMITSGDRFLKDKLLSAGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKELE ALL+ RAD+AVHS KD+P + P GL L IC+R++P DA +S + SL ALP Sbjct: 61 LFVKELEEALLDKRADLAVHSTKDMPAQLPDGLLLTAICKRDNPFDALISPQFKSLAALP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 +I+GTSSLRRQ QL P+L I++LRGN+ TRLSKL++GEY AIILA AGL+R+GL Sbjct: 121 KNAIIGTSSLRRQSQLLAYNPNLQIKTLRGNIHTRLSKLESGEYQAIILAAAGLERMGLA 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 I +P +I LP QGA+ IECR DD +EL+ LN +AL V ER +N +L G Sbjct: 181 HHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELVHGLNDPISALCVHTERRVNAKLGG 240 Query: 241 GCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 C +P Y + + + + LRA V DGSQ+I E++G +AE + E L+ GA Sbjct: 241 NCHIPFAVYCTITEEKLLLLRAKVLNMDGSQMIDDEQQGKIAEAEVIADRCTESLMTKGA 300 Query: 300 REILAEVYN 308 +L+ + + Sbjct: 301 MSLLSTIPS 309 >UniRef50_Q2RJ26 Porphobilinogen deaminase n=5 Tax=Clostridia RepID=HEM3_MOOTA Length = 313 Score = 397 bits (1020), Expect = e-109, Method: Composition-based stats. Identities = 150/303 (49%), Positives = 193/303 (63%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +++ +R+S LA WQA +V L + PGL LV + T+GD ILD LA++G KGLF KE Sbjct: 4 IKVGSRESELARWQARWVIQALEKAWPGLSCRLVTLKTKGDKILDVALARIGDKGLFTKE 63 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE+ALL+ D+AVHSMKD+P P+GL + I REDP D VS +L LP + V Sbjct: 64 LELALLDGAIDLAVHSMKDMPTTLPEGLVIGAIGPREDPADVLVSPEGYTLATLPIKARV 123 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR+ QLA RPDL + LRGNV TRL+K++ AI+LA AGLKRL + Sbjct: 124 GTSSLRRKAQLAYARPDLELVDLRGNVPTRLAKMERDGLTAIVLAAAGLKRLNHGQVLGE 183 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 +P I LPAVGQGA+G+E R D R EL+AA+NH TA V AERA LEGGCQVP Sbjct: 184 PIPYHICLPAVGQGAIGVEIRAGDRRVAELVAAINHPPTAAAVRAERAYLRALEGGCQVP 243 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 I + A + D + L+ +V + DG +++R G+ +D E G LA +LL GA EIL E Sbjct: 244 IAALATVEDTALVLQGMVASLDGREMLRDIASGSTRDPEAAGRELARKLLARGAGEILQE 303 Query: 306 VYN 308 V Sbjct: 304 VKA 306 >UniRef50_P08397 Porphobilinogen deaminase n=59 Tax=Chordata RepID=HEM3_HUMAN Length = 361 Score = 394 bits (1012), Expect = e-108, Method: Composition-based stats. Identities = 145/340 (42%), Positives = 192/340 (56%), Gaps = 33/340 (9%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 V+R+ TR+S LA Q V L AS+PGL E++ M T GD ILDT L+K+G K LF Sbjct: 19 RVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFT 78 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALP 120 KELE AL +N D+ VHS+KD+P P G + IC+RE+P DA V + +L+ LP Sbjct: 79 KELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLP 138 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGL 179 S+VGTSSLRR QL + P L RS+RGN+ TRL KLD E+ AIILA AGL+R+G Sbjct: 139 EKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQEFSAIILATAGLQRMGW 198 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 +R+ L PE + AVGQGA+G+E R D +L+ L+ ET LR AERA LE Sbjct: 199 HNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLE 258 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-----------GAPQD------ 282 GGC VP+ + + DG+++L V + DGS I+ + G D Sbjct: 259 GGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIHVPAQHEDGPEDDPQLVGI 318 Query: 283 ------------AEQMGISLAEELLNNGAREILAEVYNGD 310 A+ +GISLA LL+ GA+ IL + Sbjct: 319 TARNIPRGPQLAAQNLGISLANLLLSKGAKNILDVARQLN 358 >UniRef50_B2A1G7 Porphobilinogen deaminase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=HEM3_NATTJ Length = 311 Score = 393 bits (1011), Expect = e-108, Method: Composition-based stats. Identities = 137/310 (44%), Positives = 195/310 (62%), Gaps = 5/310 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR+S LAL Q ++V ++L +P + +E+ + T+GD +L+ L+KVGGKGLF+K Sbjct: 2 KLRIGTRRSQLALDQTNWVVEQLKTHYPDIEIEIKKIETKGDQLLNVSLSKVGGKGLFLK 61 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E++ ALL+ D+AVHSMKD+P E + L + I +R DP DA +SNN ++D LP + Sbjct: 62 EIQNALLQGEIDLAVHSMKDIPTETTEDLEICAITKRVDPLDALISNNDITIDELPENAK 121 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESRI 183 +GTSSLRR QL R DL I +RGN+ TR++KL E DA++LA AGL R G+ I Sbjct: 122 IGTSSLRRGSQLKAYRNDLQIIPIRGNINTRMNKLQELPELDAVVLAKAGLVRSGMTDSI 181 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + PEI +P GQGA+G+E R D+ +E LA L+ E+ + AERA RL G C Sbjct: 182 SQNISPEIIVPCPGQGALGLEIRHDNENLKEKLAVLDDSESRKAIGAERAFLNRLGGSCH 241 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD----AEQMGISLAEELLNNGA 299 VP+G+YAE+I E+ L +V + DG +I+ + D +G LAEEL+ GA Sbjct: 242 VPVGAYAEIISNELHLTGVVASEDGQDVIKRSVQTHLSDNNKIPSTLGNDLAEELIELGA 301 Query: 300 REILAEVYNG 309 +IL+E+ G Sbjct: 302 NKILSELKEG 311 >UniRef50_Q30Y29 Porphobilinogen deaminase n=13 Tax=Bacteria RepID=HEM3_DESDG Length = 316 Score = 393 bits (1010), Expect = e-108, Method: Composition-based stats. Identities = 163/309 (52%), Positives = 206/309 (66%), Gaps = 2/309 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPG-LVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + IATR S LALWQA ++K+++M +P VEL+ + T+GD+ILD PLAKVGGKGLF Sbjct: 2 KKIVIATRGSKLALWQAEHIKERIMQQYPDSFEVELLVLKTKGDIILDVPLAKVGGKGLF 61 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 VKE+E ALL+ RADIAVHSMKDVP+E PQGL L I ERE P D+ +S YD LDALP G Sbjct: 62 VKEIEEALLDGRADIAVHSMKDVPMELPQGLTLGAIPEREVPTDSLLSARYDGLDALPQG 121 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 ++VGTSSLRRQ Q+ RPDL ++ LRGNV TR+ KL +GEYDAII+A +GLKRLG + Sbjct: 122 AVVGTSSLRRQSQILAMRPDLEVKWLRGNVQTRIRKLMDGEYDAIIMATSGLKRLGETAP 181 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 + L P + +PAVGQGA+G+E R D E+LA L+H + + V AER L+GGC Sbjct: 182 FHSELGPPLFMPAVGQGALGLEYRSDRQDLAEMLAFLDHRPSRICVEAERGFLFGLQGGC 241 Query: 243 QVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 QVPI YA + L LV DG+ +IR G DA G++LA ++ GA Sbjct: 242 QVPIAGYAVMTGDNSFELTGLVAELDGTAVIRRTAAGTEADARDTGLTLAAQVKAAGADA 301 Query: 302 ILAEVYNGD 310 IL VY Sbjct: 302 ILQRVYENG 310 >UniRef50_Q4L709 Porphobilinogen deaminase n=88 Tax=Bacillales RepID=HEM3_STAHJ Length = 310 Score = 391 bits (1005), Expect = e-107, Method: Composition-based stats. Identities = 139/310 (44%), Positives = 196/310 (63%), Gaps = 4/310 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L + +R+S LAL Q+ DKL A P L +E+ +VT+GD I++ L+KVGGKGLFV Sbjct: 2 RKLVVGSRRSKLALTQSQQFIDKLKAVDPTLEIEIKEIVTKGDRIVNKQLSKVGGKGLFV 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE++ L + D+A+HS+KDVP P+GL L I +RE P DA++S N+ L+ LP GS Sbjct: 62 KEIQQELFDKEIDMAIHSLKDVPSIIPEGLTLGCIPDREVPFDAYISKNHIPLNELPDGS 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 I+GTSSLRR Q+ + P+L I+ +RGN+ TRL KL+ +YDAIILA AGL+R+G I Sbjct: 122 IIGTSSLRRGAQILSKYPNLEIKWIRGNIDTRLKKLEIEDYDAIILAAAGLRRMGWSDDI 181 Query: 184 -RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 L +I LPA+GQGA+GIECR DD ELL+ +++ A VTAER + ++G C Sbjct: 182 VTTYLDKDILLPAIGQGALGIECRSDDVELLELLSKVHNQAVANCVTAERTFLSAMDGSC 241 Query: 243 QVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 QVPIG YA +GEI L+ PDG++ G ++ +G +++ L GA E Sbjct: 242 QVPIGGYATNKENGEIEFTGLIMTPDGTKRYEHTEVG--KNPVDLGEAVSRVLKEQGAYE 299 Query: 302 ILAEVYNGDA 311 I+ ++ A Sbjct: 300 IIKKLNEEQA 309 >UniRef50_B3QWI1 Porphobilinogen deaminase n=12 Tax=Chlorobiaceae RepID=HEM3_CHLT3 Length = 314 Score = 390 bits (1004), Expect = e-107, Method: Composition-based stats. Identities = 144/314 (45%), Positives = 195/314 (62%), Gaps = 4/314 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + L I TR SPLALWQA ++K +L +P L + L + T GD ILD PLAK+G KGL Sbjct: 1 MKKALIIGTRSSPLALWQAEFIKAELSKHYPSLDISLRHIKTTGDKILDAPLAKIGDKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F +E+E +L N D+AVHS+KD+P E P+GL + I ERED RD +S +L LP Sbjct: 61 FTREIEHVMLRNEIDLAVHSLKDLPTETPEGLVITAITEREDNRDVLISKGKYTLKTLPQ 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+IV TSSLRR+ QL RPDL + +RGN+ TR + + G+ +A++LA AG+ RL Sbjct: 121 GAIVATSSLRRRSQLLHLRPDLEVIDMRGNLNTRFKRFEEGDAEAMLLAFAGVHRLEFSE 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 I + + LPAVGQGA+GIE R+DD TRELL LNH ET L ER++ LEGG Sbjct: 181 HIAEIISFDDILPAVGQGALGIETRIDDEETRELLKVLNHAETELCTKCERSLLRTLEGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR----GAPQDAEQMGISLAEELLNN 297 CQ+PIG++A + +G VG+ DG + I+ ++AEQ+GI +A+ Sbjct: 241 CQIPIGAHARIENGTFHFATYVGSIDGKRAIKKSLSRENVTTVEEAEQIGIEVADAARAA 300 Query: 298 GAREILAEVYNGDA 311 GA EIL E+ +A Sbjct: 301 GANEILCEIRTDNA 314 >UniRef50_C9R7U0 Porphobilinogen deaminase n=1 Tax=Ammonifex degensii KC4 RepID=C9R7U0_AMMDK Length = 308 Score = 390 bits (1002), Expect = e-107, Method: Composition-based stats. Identities = 144/304 (47%), Positives = 186/304 (61%), Gaps = 3/304 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 LRI TR S LAL Q V L P E+V + T GD + + L ++GGKGL Sbjct: 4 SKRCLRIGTRGSDLALAQTEQVLQILRERWPHYTYEIVKIKTTGDKVRNLALPRIGGKGL 63 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F KELEVALLE + D+AVHS+KD+P E P+ L + + RE P D +S L+ LP Sbjct: 64 FTKELEVALLEEKIDLAVHSLKDLPTELPEELCVGAVLPREHPGDVLISLTGAGLEDLPE 123 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLK--RLGL 179 G+ +GTSSLRRQ QL RPDL LRGNV TRL KL+ GE +A++LA AGL+ RL L Sbjct: 124 GARIGTSSLRRQAQLKAARPDLNFVPLRGNVPTRLRKLEKGECEAVVLAWAGLRRLRLDL 183 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 R+ LP ++ LPAV QGA+G+E R +D R+++ L+ T L VTAERA L Sbjct: 184 TGRMT-LLPYQVCLPAVAQGAIGVEMRKEDRELRKMVEVLDDPTTRLEVTAERAFLRWLG 242 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GGC VPI + A + EI L LV P+G +I+RG+ G+ E++GI LAE LL GA Sbjct: 243 GGCHVPIAALARVAGAEILLEGLVADPEGKRIVRGQESGSTAYPEEVGIRLAERLLREGA 302 Query: 300 REIL 303 E+L Sbjct: 303 EELL 306 >UniRef50_B3E2H7 Porphobilinogen deaminase n=3 Tax=Proteobacteria RepID=HEM3_GEOLS Length = 312 Score = 389 bits (1001), Expect = e-107, Method: Composition-based stats. Identities = 161/310 (51%), Positives = 207/310 (66%), Gaps = 1/310 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M LRI TR S LALWQA++ K +L A +PG+ VELV + T GD ILD PLA+VGGKG Sbjct: 1 MAPKRLRIGTRASQLALWQANWTKSELEARYPGIQVELVKIKTMGDKILDVPLAQVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E A+L D+AVHSMKDVP EFP+GLGLV +REDPRDAF+S + + L Sbjct: 61 LFVKEIEEAMLRGEIDLAVHSMKDVPTEFPEGLGLVVTTKREDPRDAFIS-DKVTFSELR 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GTS+LRRQ QL + RPDL + +RGNV TR+ KL DA+ILA AGL RLG Sbjct: 120 QGARIGTSALRRQAQLLKARPDLEMVIIRGNVETRIRKLKEDNLDAVILAAAGLNRLGFT 179 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 + L + S+PA+GQGA+G+ECRLDD+ T E LA LNH +TA V AERA+ R EG Sbjct: 180 DVVTELLDTDFSIPAIGQGALGLECRLDDNATIEALAFLNHADTAAAVAAERALLKRCEG 239 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPI ++ + + L + + DG Q +R G+ DA ++G LA+ LL G + Sbjct: 240 GCQVPIAAHGTVSGDTLTLVGFIASVDGKQTVRDRISGSTADAVKLGTELADRLLAAGGK 299 Query: 301 EILAEVYNGD 310 IL +VY + Sbjct: 300 AILEDVYQRE 309 >UniRef50_Q54P93 Porphobilinogen deaminase n=1 Tax=Dictyostelium discoideum RepID=HEM3_DICDI Length = 325 Score = 388 bits (997), Expect = e-106, Method: Composition-based stats. Identities = 132/317 (41%), Positives = 191/317 (60%), Gaps = 12/317 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 + I +R+S LA+ Q +V+D++ +PG++VE+ M T GD +LD L+K+G KGLF K Sbjct: 9 KVIIGSRKSQLAMLQTEWVRDRIQELNPGIIVEIKTMDTTGDKVLDVSLSKIGDKGLFTK 68 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN-----NYDSLDAL 119 ELE +L D+AVHS+KD+P + P GL L I +R + DAF++N L L Sbjct: 69 ELEDMMLNGTIDLAVHSLKDIPTKLPDGLKLGAITKRYNTSDAFIANAKKHGKNCKLSEL 128 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--DNGEYDAIILAVAGLKRL 177 P G+++G+SSLRR QL + P L + +RGN+ TR KL D+ YD +ILAVAGL+R+ Sbjct: 129 PQGAMIGSSSLRRVAQLKKAYPHLQFKDIRGNLNTRFKKLEDDSNGYDGMILAVAGLERM 188 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 L I +P ISL AVGQG++GIEC+ D + +L L H E+ AER+M Sbjct: 189 ELTDHISEIIPDSISLYAVGQGSLGIECKDGDDFIQSILNPLIHRESMYCCEAERSMLRD 248 Query: 238 LEGGCQVPIGSYAELI-----DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAE 292 LEGGC VPIG +L D + + A+V DGS+ I + G Q+G S+A+ Sbjct: 249 LEGGCHVPIGVVTKLHNQSQPDETLEINAIVLNLDGSKYIESKIIGPSIQYYQLGKSIAQ 308 Query: 293 ELLNNGAREILAEVYNG 309 +L+N G+++IL+E Sbjct: 309 DLINKGSKDILSEFIKK 325 >UniRef50_Q2LQU2 Porphobilinogen deaminase n=1 Tax=Syntrophus aciditrophicus SB RepID=HEM3_SYNAS Length = 306 Score = 385 bits (989), Expect = e-105, Method: Composition-based stats. Identities = 131/305 (42%), Positives = 186/305 (60%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 ++I TR S LAL Q + +L +P + +E+V + T GD+ D PLAK+GGKGLF+KE Sbjct: 1 MKIGTRGSALALTQTRQIAARLQGQYPEMHLEIVVIKTSGDIQKDVPLAKIGGKGLFIKE 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E ALL D+AVHSMKD+P E P+GL + + REDPRD +S D LPAG+ + Sbjct: 61 IEEALLAGTVDLAVHSMKDLPAELPEGLQIAAVPRREDPRDVLISGICREFDNLPAGARI 120 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT SLRR QL + RPDL I LRGN+ TR+ K+ D +++A AG++R+G ++ Sbjct: 121 GTGSLRRSVQLRDWRPDLEIVPLRGNLDTRIRKVAQAALDGVVVAAAGIRRMGWAEKVTQ 180 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 +P E LPAVGQG + +E R +D + LA L T VTAERA RL GGC +P Sbjct: 181 FIPTEKMLPAVGQGVLCLETREEDEDLKAGLAFLEDKRTRREVTAERAFLRRLGGGCTLP 240 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 + ++AE + +R +VG+ + +IR E G+ + A +G LAE LL+ G R +L Sbjct: 241 VAAFAEQRGDVLTIRGMVGSLNERTMIRQEIYGSVEQAVDLGTELAERLLDGGGRILLEH 300 Query: 306 VYNGD 310 + +G Sbjct: 301 LEDGQ 305 >UniRef50_A8PKX6 Porphobilinogen deaminase n=2 Tax=Gammaproteobacteria RepID=A8PKX6_9COXI Length = 311 Score = 384 bits (986), Expect = e-105, Method: Composition-based stats. Identities = 153/309 (49%), Positives = 194/309 (62%), Gaps = 3/309 (0%) Query: 1 MLDNV-LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGK 59 M LRIATR+SPLA WQA +K++L P L + L+P VT GD L + GGK Sbjct: 1 MSKKKFLRIATRKSPLAYWQATSIKNQLEKIFPFLKITLLPFVTEGDR-PSHSLNQWGGK 59 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 GLFVKELE ALL +ADIAVHS+KD+P+ +GL L IC+R DPRD +S + L Sbjct: 60 GLFVKELEAALLHGQADIAVHSLKDLPMTLEKGLVLGAICKRCDPRDVLISRSDRLFTQL 119 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P GS VGTSSLRRQ QL RPDL I LRGN+GTRL+KL GE+DAIILA AGL RL Sbjct: 120 PPGSYVGTSSLRRQSQLLALRPDLKIGVLRGNIGTRLNKLAAGEFDAIILAAAGLIRLKK 179 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 I + LPA GQGA+GIEC +D + ++AL H T V AERA++ L Sbjct: 180 TECISEYFEIDHFLPAPGQGALGIECHENDEESLTYISALIHPITHSCVLAERALSRELG 239 Query: 240 GGCQVPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GGCQVP+ +YA + I L+A VG+ DG+ I+ E++G +AE++G A++L G Sbjct: 240 GGCQVPLAAYAASLGQDFIRLQAFVGSSDGTTQIKVEKQGPRVEAEKIGFLAAQDLRALG 299 Query: 299 AREILAEVY 307 EIL + Sbjct: 300 VEEILNKFK 308 >UniRef50_A7NKU8 Porphobilinogen deaminase n=5 Tax=Bacteria RepID=HEM3_ROSCS Length = 303 Score = 382 bits (983), Expect = e-105, Method: Composition-based stats. Identities = 152/303 (50%), Positives = 195/303 (64%), Gaps = 1/303 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + N L I TR S LAL Q H ++D L A+HPGL V + + TRGD+ILD PL +G KGL Sbjct: 1 MRNSLTIGTRASKLALVQTHMIRDALQAAHPGLTVAVERITTRGDIILDRPLNAIGDKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FV E+E A+ R D+AVHS KD+P P + L R DPRDA V+ +L +LP Sbjct: 61 FVVEIEEAMRAGRVDLAVHSAKDLPSTLPPDMTLAVCPRRADPRDALVAQPGMTLASLPH 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ VGTSSLRR CQL RPDL + LRGNV TRL KL G+YDAI+LA AGLKRLGLE Sbjct: 121 GARVGTSSLRRACQLRALRPDLTLLDLRGNVDTRLRKLREGQYDAIVLAAAGLKRLGLEE 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 I L P++ +PAVGQG +G+E R D LLA L+ +TAERA R+ GG Sbjct: 181 VITELLEPDVLIPAVGQGIIGVEARAGDDEVLRLLAPLDDPAARAAITAERAFLARIGGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 C+VP+G+ A L E+ L ++GA DG +++RG R G+ D +G +LAEELL+ G + Sbjct: 241 CRVPVGALALLEGDELLLYGMIGALDG-RMVRGMRSGSASDPAGLGSALAEELLDAGGQA 299 Query: 302 ILA 304 +LA Sbjct: 300 LLA 302 >UniRef50_A3ETN3 Porphobilinogen deaminase n=2 Tax=Leptospirillum sp. Group II RepID=A3ETN3_9BACT Length = 314 Score = 382 bits (982), Expect = e-105, Method: Composition-based stats. Identities = 149/315 (47%), Positives = 191/315 (60%), Gaps = 5/315 (1%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 ML L+I +R S LALWQA +V + + G++ E+V + T GD+ILD L++VGGKG Sbjct: 1 MLPTPLKIGSRGSELALWQARHVASLIESVS-GVLPEIVVIKTTGDIILDRQLSEVGGKG 59 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E ALL D+AVHSMKDVP P GL L REDPRD F+S +Y + +LP Sbjct: 60 LFVKEIEEALLRKEIDLAVHSMKDVPAFLPPGLTLAATLTREDPRDVFLSPHYPDIKSLP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 + VGTSSLRR Q+ E R DL LRGNVGTR+ K++ G DAIILA AGL RLG Sbjct: 120 QKARVGTSSLRRLAQIREIRNDLEFIPLRGNVGTRIRKMEEGVVDAIILAGAGLLRLGHA 179 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 +R+R + P + LPA+GQGA+G+E R DD T L+ +L+ T L V AER + L G Sbjct: 180 NRVREWISPRVLLPAIGQGALGLEIRTDDETTGTLVRSLSDESTHLSVAAERGVLQSLNG 239 Query: 241 GCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERR---GAPQDAEQMGISLAEELLN 296 GCQVPI +YA + L V G++ I DA QMGI L LL+ Sbjct: 240 GCQVPIAAYAVWEKNRTLSLEGRVLDISGTRRIHARETRDIVTIDDAYQMGIDLGNRLLS 299 Query: 297 NGAREILAEVYNGDA 311 +GA EIL + + Sbjct: 300 DGAEEILNSILKKSS 314 >UniRef50_Q1J288 Porphobilinogen deaminase n=5 Tax=Deinococci RepID=HEM3_DEIGD Length = 309 Score = 382 bits (981), Expect = e-104, Method: Composition-based stats. Identities = 130/304 (42%), Positives = 181/304 (59%), Gaps = 3/304 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILD--TPLAKVGGKGL 61 + + TR S LAL Q +V +L P + + T+GD LA+ G KG Sbjct: 2 RTVTVGTRGSALALAQTRWVVARLKEEWPDTDFRIQTISTKGDRDRAALQSLAQKGDKGF 61 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALP 120 +VKE+E ALL R DIAVHS+KD+P E P+GL + +I +R D RD + + L+ LP Sbjct: 62 WVKEIEDALLAGRIDIAVHSLKDLPTEQPEGLEIASIPKRVDARDVLIGKDGMKRLEDLP 121 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 +G+ VGTSS+RR+ L RPDL I LRGN+ TRL+ L +YDAI+LA AGL R + Sbjct: 122 SGARVGTSSVRRKAFLRAYRPDLQILDLRGNIDTRLAALGTPDYDAIVLAAAGLIRTEMR 181 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 RI + P++ LPA GQGA+ +E R DD + E++ A++ H T RVTAER L Sbjct: 182 HRIDEFIDPDLLLPAPGQGALALETRADDDLSIEVVYAIHDHATDDRVTAEREFLAGLGA 241 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GC P+G++A L DG + L VGA DGSQ+IR G P + +G LA ++L GA+ Sbjct: 242 GCMAPVGAHATLKDGVLTLEGWVGALDGSQVIRATTSGDPAECADLGAELAADMLGQGAQ 301 Query: 301 EILA 304 +++ Sbjct: 302 QLIE 305 >UniRef50_Q180R9 Porphobilinogen deaminase n=11 Tax=Bacteria RepID=HEM3_CLOD6 Length = 301 Score = 380 bits (976), Expect = e-104, Method: Composition-based stats. Identities = 110/293 (37%), Positives = 171/293 (58%), Gaps = 1/293 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 + + TR S LAL Q +V ++L +P + E+ + T+GD+I + L K+G KGLFVKE Sbjct: 3 IVVGTRGSNLALIQTEWVINELKKKYPEISFEIKIIKTKGDLIQNVSLDKIGDKGLFVKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS-LDALPAGSI 124 +E LL+ + DIAVHSMKD+P GL +REDPRD + LD LP G++ Sbjct: 63 IEQQLLDGKIDIAVHSMKDMPSYLANGLKFAHTPKREDPRDVLILREGYKNLDDLPHGAV 122 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GT S RR+ QL ++RPDL I +RGNV TR+ K+ + I+LA +G+ R L+ +I Sbjct: 123 IGTGSKRRKFQLLKQRPDLNIVQVRGNVETRIRKIKDENMHGIVLAASGIIRANLQDKIS 182 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 + LP ++ +PA QGA+ IE R +DS ++ +L T +++ AER + G C + Sbjct: 183 SYLPVDVVIPAPAQGALAIEIRSNDSAIEGIVNSLKDENTEIQILAERGFLDGVNGSCHI 242 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 P+ +Y E+I +I L L G +G +++ G ++G+ LA+ +L Sbjct: 243 PMAAYCEIIQDKIHLTGLYGDSEGKKVVIKSIDGDISSPRELGLKLAKLVLKE 295 >UniRef50_A6WXJ2 Porphobilinogen deaminase n=56 Tax=cellular organisms RepID=HEM3_OCHA4 Length = 314 Score = 380 bits (976), Expect = e-104, Method: Composition-based stats. Identities = 132/306 (43%), Positives = 174/306 (56%), Gaps = 2/306 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGG 58 + + L+I TR S LAL QA+ + +LM +H P +E++PM T GD I D L+++GG Sbjct: 6 LKNGTLKIGTRGSKLALAQAYETRRRLMEAHGLPEEAIEIIPMSTAGDRIQDRALSEIGG 65 Query: 59 KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118 KGLF +E+E AL + R D+AVHS KD+P P GL L EREDPRDAF+ L Sbjct: 66 KGLFTEEIEQALTDGRIDLAVHSTKDMPTVLPDGLHLSVFLEREDPRDAFIGRTASRLLD 125 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 LP G+ VG+SSLRRQ + RPD+ + RGNV TRL KL+ GE D LA AGL+RLG Sbjct: 126 LPQGATVGSSSLRRQALIRRLRPDIQVVIFRGNVDTRLRKLEAGEVDGTFLACAGLRRLG 185 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 L I PE PA GQGA+GIE R+ D+R LLA L H ET + + ERA L Sbjct: 186 LGDVITDLADPESFPPAPGQGAIGIETRIGDTRIDTLLAPLAHRETGIALACERAFLAAL 245 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 +G C+ PI A + + ++ PDGS+ + G +A +G AE L Sbjct: 246 DGSCRTPIAGLATVNGDTVSFHGMILKPDGSEAHEIKTEGPASNAAAIGTEAAEHLRAKA 305 Query: 299 AREILA 304 + Sbjct: 306 GPQFFE 311 >UniRef50_B6FXV9 Putative uncharacterized protein n=1 Tax=Clostridium hiranonis DSM 13275 RepID=B6FXV9_9CLOT Length = 299 Score = 379 bits (975), Expect = e-104, Method: Composition-based stats. Identities = 113/298 (37%), Positives = 176/298 (59%), Gaps = 1/298 (0%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +R+ TR S LAL Q ++ D+L P + E+ + T+GD IL L K+G KGLFVK Sbjct: 2 KIRVGTRGSNLALIQTNWAIDRLKEKFPEVEFEVKIIKTKGDKILHLSLDKIGDKGLFVK 61 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALPAGS 123 E+E LLE D+AVHSMKD+P E +GL + +REDPRD + +S D LP G+ Sbjct: 62 EIESQLLEGEIDLAVHSMKDMPAEVVEGLKFAAVPKREDPRDVIILREGLNSFDELPIGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +GT S RR+ QL +RPDL I +RGN+ TR+SK+++ D I+LA +G+ R LE +I Sbjct: 122 TIGTGSKRRKYQLLRKRPDLNIVPIRGNIETRISKIESENLDGIVLAASGVIRADLEEKI 181 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 LP ++ +PA QGA+ +E R +D +++ A+ + ++ AER+ ++G C Sbjct: 182 TEFLPVDLMIPAPAQGALALEIRENDEELEKMIDAIKDEISQIQTDAERSYLAGIDGSCH 241 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 +P+G+Y E+ ++ L + G DG +I G + +++G +LA+ +L E Sbjct: 242 IPMGAYCEVDGEKLTLTGIFGDEDGEKITVASLEGDRDNPKELGSNLAKLVLKKHREE 299 >UniRef50_B2S842 Porphobilinogen deaminase n=38 Tax=Rhizobiales RepID=HEM3_BRUA1 Length = 314 Score = 377 bits (970), Expect = e-103, Method: Composition-based stats. Identities = 134/305 (43%), Positives = 170/305 (55%), Gaps = 2/305 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGK 59 + L+I TR S LAL QA+ + L +H P +E++PM T GD I D PL++VGGK Sbjct: 7 KNGTLKIGTRGSKLALAQAYLTRRLLQEAHGLPEDAIEILPMSTAGDRIQDRPLSEVGGK 66 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 GLF +E+E AL + R DIAVHS KD+P P+GL L EREDPRDAF+ + L Sbjct: 67 GLFTEEIEQALKDGRIDIAVHSTKDMPTALPEGLHLSVFLEREDPRDAFIGRSARRFMDL 126 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P G+ VG+SSLRRQ + RPD+ + RGNV TRL KLD GE D LA AGL+RLGL Sbjct: 127 PQGATVGSSSLRRQALIRRLRPDIEVVMYRGNVDTRLRKLDAGEVDGTFLACAGLRRLGL 186 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 I L P + PA GQGA+GIE R+ D R LLA L H ET + + ERA L+ Sbjct: 187 ADVITDVLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERAFLGALD 246 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 G C+ PI A + + R ++ PDG Q G DA +G A + Sbjct: 247 GSCRTPIAGLATVEGDRLSFRGMILTPDGRQAHEVTAEGVVSDAAALGTDAANRVRAMAG 306 Query: 300 REILA 304 Sbjct: 307 PHFFD 311 >UniRef50_A7GYU4 Porphobilinogen deaminase n=34 Tax=Campylobacterales RepID=HEM3_CAMC5 Length = 311 Score = 377 bits (970), Expect = e-103, Method: Composition-based stats. Identities = 160/307 (52%), Positives = 200/307 (65%), Gaps = 3/307 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +L+IATR+S LALWQ+ ++K +LMA H GL VELV M T+GDVILDTPLAK+GGKGLF Sbjct: 2 KILKIATRKSALALWQSEHIKARLMAQHAGLQVELVGMKTKGDVILDTPLAKIGGKGLFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE ++L + IAVHS+KDVPV F GL L IC RED RDA +S Y D LP + Sbjct: 62 KELEDSMLSGQTHIAVHSLKDVPVAFLDGLVLAAICSREDVRDAMISQRYVKFDDLPQSA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGT+SLRR+ QL RPDL I SLRGNV TRL KL GE+DAIILA+AG+ RL L + Sbjct: 122 KVGTTSLRRKMQLLRMRPDLNIISLRGNVQTRLRKLKEGEFDAIILAMAGINRLNLADEV 181 Query: 184 RAALPPEI--SLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 P +I PA+GQGA+G+E +DD++ E + LN + + ER T LEGG Sbjct: 182 AHIYPFDIAQMTPAMGQGALGVEA-VDDAQILEKIKFLNDERSVIETRVERDFVTLLEGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 CQVPIG A L EI + A+VG PDGS++I + E +G LA E + GA+E Sbjct: 241 CQVPIGINARLASEEIEINAIVGLPDGSEVITENLTAKKSEFESVGKELAREFIARGAKE 300 Query: 302 ILAEVYN 308 +L Sbjct: 301 LLKRAEE 307 >UniRef50_O94048 Porphobilinogen deaminase n=53 Tax=Saccharomyceta RepID=HEM3_CANAL Length = 340 Score = 375 bits (965), Expect = e-103, Method: Composition-based stats. Identities = 129/319 (40%), Positives = 185/319 (57%), Gaps = 17/319 (5%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 N ++I R+S LA+ Q+ VK + + P L ++ + T GD + PL GGK L+ Sbjct: 11 SNHVQIGGRKSKLAVVQSEIVKKVIEDTFPNLSCSILALSTLGDKVQTQPLYTFGGKSLW 70 Query: 63 VKELEVALLEN-----RADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---D 114 KELE+ LL++ + D+ VHS+KD+P P+ L I +REDPRDA V Sbjct: 71 TKELEILLLDSVDEFPKLDLIVHSLKDMPTNLPEEFELGCIFQREDPRDAIVMKQGSSYK 130 Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVA 172 SL LPAG+IVGTSS+RR QL + P L S+RGN+ TRL+KLD N EY +ILA A Sbjct: 131 SLKDLPAGAIVGTSSIRRSSQLIKNYPHLRFESVRGNIQTRLNKLDQPNNEYCCLILASA 190 Query: 173 GLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232 GL RLGL RI + L + AVGQGA+GIE R D + +L + + AER Sbjct: 191 GLIRLGLGHRITSYL--DDMYYAVGQGALGIEIRKGDDNIKSILKKIEDPIATICCLAER 248 Query: 233 AMNTRLEGGCQVPIGSYAELIDGE--IWLRALVGAPDGSQIIRGER---RGAPQDAEQMG 287 ++ LEGGC VP+G +++ + + + L+ ++ +PDG+ I E +D EQ+G Sbjct: 249 SLMRYLEGGCSVPLGVHSDYNESKQELTLKGIIVSPDGTVSIEDEVIKRITCDEDCEQVG 308 Query: 288 ISLAEELLNNGAREILAEV 306 I L ++L GA+EIL ++ Sbjct: 309 IELGDKLKAKGAKEILDKI 327 >UniRef50_A6Q7Y4 Porphobilinogen deaminase n=7 Tax=Epsilonproteobacteria RepID=HEM3_SULNB Length = 323 Score = 375 bits (963), Expect = e-102, Method: Composition-based stats. Identities = 137/319 (42%), Positives = 191/319 (59%), Gaps = 10/319 (3%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L IATR S LALWQA+++K+++ + P + VEL + ++GD ILD PLA VGGKG F Sbjct: 2 EKLVIATRASNLALWQAYHIKERIETAFPEVRVELNEITSKGDKILDKPLALVGGKGHFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE ++ A +AVHS+KDVP P+GL L I ER+D D F+S+ Y SL LP G+ Sbjct: 62 KELEDEMIAGNAHLAVHSLKDVPTYIPEGLELCAITERQDQSDVFLSHTYKSLSELPEGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +VGT+SLRR+ QL E+RPDL ++ LRGNV TRL KL G+YDAIILA GL RL L I Sbjct: 122 VVGTTSLRRRMQLLEKRPDLKVKDLRGNVNTRLRKLKEGQYDAIILAYIGLYRLDLLKDI 181 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + +P +GQ A+GIE ++ R RE+ LNH T + ER + + GC Sbjct: 182 PYVEKLDFFIPPMGQAALGIEIVANNDRIREIAMTLNHEPTFICTKVERDFISVIGAGCS 241 Query: 244 VPIGSYAELIDGE------IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 P+ A + E I +RA++G PDG+ I+ +A+ +G LA+ ++ Sbjct: 242 APVAVNATMDKKEDDKVPTISVRAMIGYPDGTHILHKSLTVPLNEADILGDELAQAMIEE 301 Query: 298 GAREILAE----VYNGDAP 312 GA +IL + + + P Sbjct: 302 GALDILEQAEIIAFKDEMP 320 >UniRef50_D0LUE1 Porphobilinogen deaminase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LUE1_HALO1 Length = 320 Score = 373 bits (959), Expect = e-102, Method: Composition-based stats. Identities = 156/315 (49%), Positives = 196/315 (62%), Gaps = 11/315 (3%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M + + I+TR S LALWQAH+V+D++ P VELV + T+GD ILD PL+K+GGK Sbjct: 1 MSERTIHISTRGSQLALWQAHHVRDEIRRVRPAWQVELVIIKTQGDKILDVPLSKIGGKA 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E ALL+ RAD+AVHSMKDVP E GL + REDP DA + + LD L Sbjct: 61 LFVKEIEQALLDGRADVAVHSMKDVPAELAPGLFMAATSRREDPYDALCTRDGRGLDELA 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GTSSLRRQCQ+ RRPDL I LRGNV TRL KLD+G +DA+ILA AGLKRLG Sbjct: 121 EGATLGTSSLRRQCQILARRPDLRIEMLRGNVPTRLGKLDDGSFDAVILAAAGLKRLGHG 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDD-----SRTRELLAALNHHETALRVTAERAMN 235 RI L + +PAVGQG +GIE R D L AL+ RV AERAM Sbjct: 181 ERISQRLDGGVCVPAVGQGVLGIETRQGDAPADRELVEALREALHDPAEERRVVAERAMM 240 Query: 236 TRLEGGCQVPIGSYAELIDG------EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGIS 289 L G CQ P+ ++A + + L G PDGS+I+R + G +DA+ +G S Sbjct: 241 AALGGSCQTPLAAHASYRGDSDPVAGTLVIEGLCGRPDGSEILRAQVEGRAEDAQALGSS 300 Query: 290 LAEELLNNGAREILA 304 LAEEL GA+ I+ Sbjct: 301 LAEELRGQGAQAIID 315 >UniRef50_Q43316 Porphobilinogen deaminase, chloroplastic n=61 Tax=cellular organisms RepID=HEM3_ARATH Length = 382 Score = 372 bits (957), Expect = e-102, Method: Composition-based stats. Identities = 137/303 (45%), Positives = 185/303 (61%), Gaps = 8/303 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGL----VVELVPMVTRGDVILDTPLAKVGGKG 60 ++RI TR SPLAL QA+ ++KL HP L + + + T GD IL PLA +GGKG Sbjct: 74 IIRIGTRGSPLALAQAYETREKLKKKHPELVEDGAIHIEIIKTTGDKILSQPLADIGGKG 133 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF KE++ AL+ DIAVHSMKDVP P+ L RED RDAF+ +L LP Sbjct: 134 LFTKEIDEALINGHIDIAVHSMKDVPTYLPEKTILPCNLPREDVRDAFICLTAATLAELP 193 Query: 121 AGSIVGTSSLRRQCQLAERRPDLII-RSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 AGS+VGT+SLRR+ Q+ + P L + + RGNV TRLSKL G+ A +LA+AGLKRL + Sbjct: 194 AGSVVGTASLRRKSQILHKYPALHVEENFRGNVQTRLSKLQGGKVQATLLALAGLKRLSM 253 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 + + L + LPAV QGA+GI CR DD + LA+LNH ET L ++ ERA L+ Sbjct: 254 TENVASILSLDEMLPAVAQGAIGIACRTDDDKMATYLASLNHEETRLAISCERAFLETLD 313 Query: 240 GGCQVPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGA--PQDAEQMGISLAEELLN 296 G C+ PI YA + +G R LV +PDG++++ R+G +D +MG +ELL+ Sbjct: 314 GSCRTPIAGYASKDEEGNCIFRGLVASPDGTKVLETSRKGPYVYEDMVKMGKDAGQELLS 373 Query: 297 NGA 299 Sbjct: 374 RAG 376 >UniRef50_D2R3S6 Porphobilinogen deaminase n=2 Tax=Planctomycetaceae RepID=D2R3S6_9PLAN Length = 311 Score = 372 bits (957), Expect = e-102, Method: Composition-based stats. Identities = 144/303 (47%), Positives = 192/303 (63%), Gaps = 2/303 (0%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LR+ TR SPLA WQA +V+D+L+A+ G+ VE++ + T GD PL ++GG+GLF K Sbjct: 6 KLRLGTRASPLARWQADWVRDQLIAA--GIDVEMILITTEGDQQTSQPLGQIGGQGLFTK 63 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E++ LL D+AVHS+KD+P GL L + ERED D + SL LP+G+ Sbjct: 64 EIQRRLLAGDIDLAVHSLKDLPTLPIDGLSLAAVPEREDTADILIGPAGTSLATLPSGAK 123 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GT SLRR+ QL R DL I +RGNV TRL KLD G+Y AIILA AGLKRL L+ R+ Sbjct: 124 IGTGSLRRKAQLLHARADLEILDIRGNVDTRLRKLDEGQYHAIILAAAGLKRLKLDDRMT 183 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L + LPAVGQGA+GIE R DD TR+LLA L+H T V AER++ L GC Sbjct: 184 ERLEAPLMLPAVGQGALGIESRSDDPTTRKLLAPLSHAPTLQAVIAERSLLAALRAGCLA 243 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 P+G++A+++DG++ L A+V + DG + AP DA Q+G +AE L GA E+LA Sbjct: 244 PVGAHAQVVDGQLTLAAVVLSIDGQSRLFASLTSAPADAAQLGEEVAELLRQQGATELLA 303 Query: 305 EVY 307 Sbjct: 304 SSR 306 >UniRef50_P28789 Porphobilinogen deaminase n=18 Tax=Saccharomycetales RepID=HEM3_YEAST Length = 327 Score = 371 bits (954), Expect = e-101, Method: Composition-based stats. Identities = 123/322 (38%), Positives = 177/322 (54%), Gaps = 15/322 (4%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M L I R+S LA+ Q+++V + +P ++ + T GD I PL GGK Sbjct: 1 MGPETLHIGGRKSKLAVIQSNHVLKLIEEKYPDYDCKVFTLQTLGDQIQFKPLYSFGGKA 60 Query: 61 LFVKELEVALL----ENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NY 113 L+ KELE L + D+ VHS+KD+P P+G L I +R DP D V Y Sbjct: 61 LWTKELEDHLYHDDPSKKLDLIVHSLKDMPTLLPEGFELGGITKRVDPTDCLVMPFYSAY 120 Query: 114 DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAV 171 SLD LP G IVGTSS+RR QL + P L S+RGN+ TRL KLD+ + Y IILA Sbjct: 121 KSLDDLPDGGIVGTSSVRRSAQLKRKYPHLKFESVRGNIQTRLQKLDDPKSPYQCIILAS 180 Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231 AGL R+GLE+RI + AVGQGA+GIE R D++ ++L + + +E Sbjct: 181 AGLMRMGLENRITQRFHSDTMYHAVGQGALGIEIRKGDTKMMKILDEICDLNATICCLSE 240 Query: 232 RAMNTRLEGGCQVPIGSYAELIDG--EIWLRALVGAPDGSQIIRGE----RRGAPQDAEQ 285 RA+ LEGGC VPIG ++ + ++ L+A+V +G++ + E +D+ Sbjct: 241 RALMRTLEGGCSVPIGVESKYNEETKKLLLKAIVVDVEGTEAVEDEIEMLIENVKEDSMA 300 Query: 286 MGISLAEELLNNGAREILAEVY 307 G LAE ++ +GA++IL E+ Sbjct: 301 CGKILAERMIADGAKKILDEIN 322 >UniRef50_A5VM67 Porphobilinogen deaminase n=9 Tax=Lactobacillus RepID=HEM3_LACRD Length = 305 Score = 370 bits (952), Expect = e-101, Method: Composition-based stats. Identities = 118/298 (39%), Positives = 167/298 (56%), Gaps = 4/298 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + N + + +R+S LA+ Q V L P + E+ ++T GD LAK+GGKG+ Sbjct: 1 MTNKVIVGSRKSKLAMAQTELVIASLEKIFPDIKFEIKNVITEGDRNRHVSLAKIGGKGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALP 120 FVKE+E L + D AVHS+KDV P+ L L +R P D VS SL+ LP Sbjct: 61 FVKEIEDELKDGTIDFAVHSLKDVMPILPEELVLGAFPKRVSPYDCLVSRKNLSSLNDLP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GT+SLRRQ QL RPDL I +RGN+ TRL K+D D IILA AGL RL ++ Sbjct: 121 KGARIGTNSLRRQGQLLSIRPDLKIIPIRGNIDTRLRKIDTEALDGIILAEAGLTRLNID 180 Query: 181 SRIRAALPPE-ISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 L + +PAVGQG + IECR +D+R R++L +N E+A V ER L Sbjct: 181 LSSYHVLDLQNYIMPAVGQGCLAIECRKNDTRIRKMLDQINDEESAYCVQVEREFMRELG 240 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 G C PIG +A +G+I L+ +P+G +I+ + P + +G +A++LL Sbjct: 241 GSCNFPIGGHAYAKNGQILFDGLIASPNGEHVIKETKI--PANNSGVGKKVADQLLAK 296 >UniRef50_Q8RFP5 Porphobilinogen deaminase n=16 Tax=Fusobacteriaceae RepID=HEM3_FUSNN Length = 298 Score = 370 bits (950), Expect = e-101, Method: Composition-based stats. Identities = 119/298 (39%), Positives = 166/298 (55%), Gaps = 5/298 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPL--AKVGGK 59 + + I +R S LAL QA+ VKD+L ++P L E+ +VT GD L + + + K Sbjct: 1 MKKNIIIGSRGSILALAQANLVKDRLQGNYPNLSFEIKEIVTSGDKDLKSNWENSDISLK 60 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 F KE+E LL+ DIAVHSMKD+P + L I +REDPRD VS N L L Sbjct: 61 SFFTKEIEQELLDGEIDIAVHSMKDMPAVSAKSLICGAIPDREDPRDVLVSKNGL-LVTL 119 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P G+ VGTSSLRR L RPD I+ LRGN+ TRL KL+ +YDAI+LA AGLKR GL Sbjct: 120 PQGAKVGTSSLRRAMNLKTVRPDFEIKHLRGNIHTRLKKLETEDYDAIVLAAAGLKRTGL 179 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 +I L E+ PA QG + I+CR +D +E+L ++++ A V ER + + Sbjct: 180 ADKITEYLNGEVFPPAPAQGVLYIQCRENDEEIKEILKSIHNEAIAKIVEIEREFSKIFD 239 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 GGC P+G Y+++ +I A+ D + IR +++ AEE+ N Sbjct: 240 GGCHTPMGCYSQVNGDKIKFTAVY--LDEGKQIRAVVEDDLAKGKEIAYMAAEEIKNK 295 >UniRef50_UPI0001926E0E PREDICTED: similar to hydroxymethylbilane synthase, partial n=1 Tax=Hydra magnipapillata RepID=UPI0001926E0E Length = 418 Score = 369 bits (948), Expect = e-101, Method: Composition-based stats. Identities = 123/342 (35%), Positives = 167/342 (48%), Gaps = 35/342 (10%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + + +R+S LA+ Q + L + + M T GD IL L K+G K LF Sbjct: 28 KTSVVVGSRKSQLAVIQTKSIVAALCQKEKDVECIIETMDTLGDKILHIALPKIGEKSLF 87 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDAL 119 K+LE+AL E R D VHS+KD+P PQG+ + TI +R+DPRD + + N L L Sbjct: 88 TKDLELALSEKRVDFLVHSLKDLPTTLPQGMAISTIYKRDDPRDCIIFHPKHNGKKLADL 147 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-YDAIILAVAGLKRLG 178 P SI+GTSSLRR QL + L +S+RGN+ TRL KL+ YDAI+LA AG+ R+G Sbjct: 148 PENSIIGTSSLRRVAQLKRKYNKLTFQSVRGNLNTRLQKLEEESLYDAIVLAKAGVDRMG 207 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 +I L + L A+GQGA+ +E R DD T +LA L ET L AER L Sbjct: 208 WTEKIGQILSEDECLYAIGQGAITVEVRNDDKYTISILAQLTDMETLLACVAERCFMRTL 267 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ----------------- 281 GGC PI +++ LR +V DGS+ + Q Sbjct: 268 NGGCSTPIACHSQFSGNNYSLRGIVLNADGSRFLDSTVSTTLQVNILTDQNEPPSYTVSK 327 Query: 282 --------------DAEQMGISLAEELLNNGAREILAEVYNG 309 AE+ G LA L GA ++L EV + Sbjct: 328 SGVVINSLYINEFIKAEKCGEELAYCLKKLGADDVLKEVRSK 369 >UniRef50_C8WXM9 Porphobilinogen deaminase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WXM9_ALIAD Length = 305 Score = 369 bits (947), Expect = e-101, Method: Composition-based stats. Identities = 151/301 (50%), Positives = 196/301 (65%), Gaps = 2/301 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 LR+ATR+S LAL Q ++V D L G+ ELVP+ TRGD I+D L++VGGKGLFV Sbjct: 2 RTLRVATRRSALALTQTNHVVDLLKQVAHGVEFELVPIRTRGDEIVDRALSEVGGKGLFV 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 ++E AL +AD+AVHS+KDVP E GL + + REDPRDA +S L LP G+ Sbjct: 62 ADIEDALATGQADLAVHSLKDVPFELRDGLTIGAVPPREDPRDALISRTGQGLFDLPPGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGTSSLRRQ L RPDL + +LRGNV TRL +L+ G++DAI+LA +GL RLGL RI Sbjct: 122 RVGTSSLRRQAALRRLRPDLCVETLRGNVDTRLRRLEEGQFDAIVLAASGLHRLGLAERI 181 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 LP + +PAVGQGA+ IECR +D LAA+ + V AERA +RLEG CQ Sbjct: 182 TEYLPVDRFVPAVGQGALAIECRAEDDEVMRHLAAIADPDATRAVEAERAFLSRLEGSCQ 241 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 VPIG+YAE + E+ L A V P G ++ ER G +A +G+++AEE+L GA + L Sbjct: 242 VPIGAYAEPVGHELRLIAFVADPSGIHHLQLERTG--DEARALGVAMAEEMLRQGAEDWL 299 Query: 304 A 304 Sbjct: 300 K 300 >UniRef50_B3T8H9 Putative Porphobilinogen deaminase, dipyromethane cofactor binding domain protein n=1 Tax=uncultured marine microorganism HF4000_APKG5H11 RepID=B3T8H9_9ZZZZ Length = 322 Score = 369 bits (947), Expect = e-100, Method: Composition-based stats. Identities = 122/306 (39%), Positives = 171/306 (55%), Gaps = 1/306 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +++ +R S LAL Q H V ++L A+ P L E+ + TRGDV + LA +G G+FVKE Sbjct: 18 IKVGSRGSTLALIQDHVVINRLKANSPALEFEVDTVRTRGDVDQTSRLAGMG-LGIFVKE 76 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE LL+ + DIAVHS+KD+P + GL L + REDPRD V+ LD LP G+ + Sbjct: 77 LEQELLDGKLDIAVHSLKDMPTQLADGLVLGAVLSREDPRDVLVNRYGCPLDGLPKGAKI 136 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS RR QL + P + + S+RGNV TRL K E D ILA AG+ RLGL+ +I Sbjct: 137 GTSSPRRAAQLKQYAPQVEVVSIRGNVETRLRKAQGEEADGAILAAAGMIRLGLQDQIAE 196 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L +P GQG + +E R DD R ELL+A++ +T TAER RL GGC +P Sbjct: 197 YLSATQFVPPPGQGILAVEARADDFRMLELLSAIDDADTRYEATAERGFLARLGGGCSIP 256 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 +G+YA I + + DG + + +G +D Q+ L+ G +++A Sbjct: 257 VGAYARCNGDNIVMTIYMSTADGEKKFSAKIQGLKRDPLQLANDAYLALVERGGADLVAA 316 Query: 306 VYNGDA 311 A Sbjct: 317 ARANQA 322 >UniRef50_A9A1A1 Probable porphobilinogen deaminase n=3 Tax=Thaumarchaeota RepID=HEM3_NITMS Length = 311 Score = 369 bits (947), Expect = e-100, Method: Composition-based stats. Identities = 107/298 (35%), Positives = 171/298 (57%), Gaps = 2/298 (0%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 + R S L++ Q + V +L +HP E+ + T+GD PL + KG+F K Sbjct: 2 KYIVGARGSQLSVAQTNLVIAELKKAHPDTEYEIKTITTKGDTD-SRPLFTIDQKGIFEK 60 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E++ A+ + D AVHS+KDVP E L L I +RE D F+S + +LD++ GS+ Sbjct: 61 EIDRAVAQKEVDFAVHSLKDVPSELDDNLVLACIPKRETVNDVFISPDGSTLDSIKPGSV 120 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSSLRR Q++ +RPD+ ++ +RGN+ TR+ K YDAI+LA AG+ RLG++ + Sbjct: 121 IGTSSLRRAVQVSRKRPDVTVKPIRGNIETRIKKASGENYDAIVLAKAGISRLGVDVKYT 180 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L + P+ GQGA+ I R DDS+T E+L + ++ L + AERA++ ++ GC+ Sbjct: 181 E-LSTDDFSPSPGQGAIAIVARADDSKTIEMLKKIEDPDSRLEIEAERALSDFVDSGCRF 239 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 P+G+YA+ E+ L + DG Q + + G + + +G S EEL G ++ Sbjct: 240 PVGAYAKSNGSEMTLTVTAFSVDGKQFLHVSKTGDKNNPKSLGQSAGEELREKGVNDL 297 >UniRef50_A8LIJ6 Porphobilinogen deaminase n=11 Tax=Alphaproteobacteria RepID=A8LIJ6_DINSH Length = 347 Score = 368 bits (945), Expect = e-100, Method: Composition-based stats. Identities = 144/304 (47%), Positives = 191/304 (62%), Gaps = 2/304 (0%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKG 60 D+ L+I TR S LAL QAH + +L A+ P E+V + T GD I D L+++GGKG Sbjct: 38 DSPLKIGTRGSLLALAQAHETRARLSAAFDLPEEAFEIVVIKTTGDRIQDRSLSEIGGKG 97 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF +E+E A+L+ DIAVHSMKD+PV+ P GL L T RED RDAFV+ + +L LP Sbjct: 98 LFTREIEDAMLDGSIDIAVHSMKDMPVDTPAGLALDTYLPREDVRDAFVTLDGGTLADLP 157 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G++VG+SSLRR+ QLA RRPDL + RGNV TR+ KL +G A LA+AGL RLG++ Sbjct: 158 EGAVVGSSSLRRRAQLAHRRPDLQLVEFRGNVQTRMKKLGDGVAHATFLAMAGLNRLGMD 217 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R+A+ PE LPAV QG +GIE R DD R E+LAA++ + R+ ERA + L+G Sbjct: 218 EVPRSAIAPEDMLPAVAQGCIGIERRADDPRAAEMLAAIHDGPSGHRLACERAYLSALDG 277 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 CQ PI AEL G I LRA + PDGS+++ +DA +MG +AE L Sbjct: 278 SCQTPIAGLAELDGGSIHLRAEILRPDGSEVLSDSETAPVEDAAKMGREVAERLRARAPD 337 Query: 301 EILA 304 + Sbjct: 338 GFFS 341 >UniRef50_UPI00017922DC PREDICTED: similar to porphobilinogen deaminase n=1 Tax=Acyrthosiphon pisum RepID=UPI00017922DC Length = 377 Score = 368 bits (945), Expect = e-100, Method: Composition-based stats. Identities = 130/364 (35%), Positives = 186/364 (51%), Gaps = 59/364 (16%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +R+ +R+S LAL Q +V +L HP + E+V M T GD +LD PL K+G K LF Sbjct: 7 KTIRVGSRKSELALIQTKFVISQLKELHPEIEFEIVSMTTMGDRVLDKPLPKIGEKSLFT 66 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS---LDALP 120 K+LEVALL D VHS+KD+P G + I +R+DPRDA V + LD+LP Sbjct: 67 KDLEVALLSGTVDFIVHSLKDLPTVMEIGTTIGAILKRDDPRDALVLRDDCKEYQLDSLP 126 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE---------YDAIILAV 171 + S +GTSSLRR QL + P+L + +RGN+ TRL KLD+ + Y IILA+ Sbjct: 127 SKSFIGTSSLRRTAQLKRKFPNLQVSDVRGNLNTRLKKLDSSQSTGDNTNTNYSGIILAL 186 Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231 AG++R+G E R+ + ++ L AVGQGA+ +ECRL D E+L L+H+ET L+V AE Sbjct: 187 AGIQRMGWEKRVSQIIDSDVMLYAVGQGALAVECRLGDDYILEMLEPLHHYETVLQVVAE 246 Query: 232 RAMNTRLEGGCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQD------- 282 R TRL GGC P+G + + + L V + DG++ ++ D Sbjct: 247 RGFLTRLGGGCSAPVGIRSTVCLTKNAMSLDGAVWSLDGAEELQYSSSAELADKKVIQSH 306 Query: 283 --------------------------------------AEQMGISLAEELLNNGAREILA 304 A ++G LAE L++ GA +I+ Sbjct: 307 IDQYRGEDGEPPKKCPYKQPRQFVGVTPGKISYLDLDTALKLGTELAENLISKGALDIMN 366 Query: 305 EVYN 308 Sbjct: 367 AAKE 370 >UniRef50_C1CYD9 Porphobilinogen deaminase n=3 Tax=Deinococci RepID=HEM3_DEIDV Length = 311 Score = 367 bits (944), Expect = e-100, Method: Composition-based stats. Identities = 126/310 (40%), Positives = 176/310 (56%), Gaps = 5/310 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDT--PLAKVGGKGL 61 + + TR S LAL Q +V +L P + + T+GD ++ +A+ G KG Sbjct: 2 RTVTVGTRGSTLALAQTRWVVARLKEEWPDTDFRIQTISTKGDRNRESLEAMAQKGDKGF 61 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALP 120 +VKE+E ALL+ R DIAVHS+KD+P E P+GL + +I +R D RD + L LP Sbjct: 62 WVKEIEDALLQKRIDIAVHSLKDLPTEQPEGLEVASIPKRVDARDVLIGKEGMKRLADLP 121 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGTSS+RR+ L RPDL + LRGN+ TRL+ L EYDAIILA AGL R + Sbjct: 122 QGARVGTSSVRRKAFLRAYRPDLQVIDLRGNIDTRLAALAGDEYDAIILAAAGLIRTEMR 181 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSR--TRELLAALNHHETALRVTAERAMNTRL 238 RI + P+I LPA GQGA+ +E R T E+ A++ H T R+TAER L Sbjct: 182 HRIDEFVEPDILLPAPGQGALALETRSGPENDLTIEVAYAIHDHGTDDRITAEREFLAGL 241 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GC P+G++A + G + L VGA DGS++IR G P + +G LA ++L G Sbjct: 242 GAGCMAPVGAHASIKGGVLTLEGWVGALDGSKVIRATSIGDPAECADIGAELAGDMLGQG 301 Query: 299 AREILAEVYN 308 A+ ++ Sbjct: 302 AQALIDAARE 311 >UniRef50_D1CBT4 Porphobilinogen deaminase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CBT4_THET1 Length = 300 Score = 367 bits (944), Expect = e-100, Method: Composition-based stats. Identities = 111/295 (37%), Positives = 170/295 (57%), Gaps = 2/295 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 V+++ TR S LALWQ +V ++L + +PG E V + D D P++ +G G+F Sbjct: 2 KVIKVGTRGSKLALWQTQWVINRLRSLYPGFQFEPVVIKVTSDRSPDAPISAIGQVGVFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 K++E ALL +AVHS+KD+P G + EREDPRD + + L S Sbjct: 62 KDIEQALLAGDIHLAVHSLKDLPTLSTPGTVIAAFTEREDPRDCILWPKGQPMPDL-NNS 120 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGTSS+RR + P+ + +LRGNV TR+ K+ G YD +++A A +KR+ L Sbjct: 121 RVGTSSVRRSALVRSYWPNANVVNLRGNVDTRVRKMLEGNYDVVLMAYAAVKRMDLPVEF 180 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + LP + +P+ GQG + ++ R DD + +L A+N + + AER++ L GGC Sbjct: 181 K-PLPLDSWVPSAGQGIIAVQAREDDQQIIGMLNAINFFPSKVAYLAERSLMRALGGGCS 239 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 +P+G+YAEL DGE+ L +V APDGSQ++ R P A+ +G +A E+L+ G Sbjct: 240 MPVGAYAELHDGELSLIGMVAAPDGSQVVITRRVDTPDQADHLGERVAREMLDLG 294 >UniRef50_C3WGN0 Porphobilinogen deaminase n=5 Tax=Fusobacterium RepID=C3WGN0_9FUSO Length = 301 Score = 366 bits (941), Expect = e-100, Method: Composition-based stats. Identities = 122/311 (39%), Positives = 172/311 (55%), Gaps = 13/311 (4%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPL--AKVGGK 59 + + I +R S LAL QA VK+ L A++P L E+ +VT GD L + + K Sbjct: 1 MKRHVVIGSRGSILALAQASLVKNSLEANYPDLTFEIKEIVTSGDKDLKSNWENSNASLK 60 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 F KE+E LL+ + DIAVHSMKD+P P+GL I +RED RD +S N L L Sbjct: 61 SFFTKEIEQELLDGQIDIAVHSMKDMPAVSPKGLICGAIPDREDARDVLISKNG-FLVTL 119 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P G+ +GTSSLRR L RPD I+ LRGN+ TRL KL+ +YDAIILA AGLKR G+ Sbjct: 120 PQGAKIGTSSLRRVMNLKAIRPDFEIKHLRGNIHTRLKKLETEDYDAIILAAAGLKRTGM 179 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 +I L E PA QG + I+CR +D + +L ++++ + A V ER + + Sbjct: 180 ADKITEYLSGEAFPPAPAQGVLYIQCRENDEEIKGILKSIHNEDIAKIVEIEREFSKIFD 239 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GGC P+G Y+++ + +I A + DG Q R +D G +A + A Sbjct: 240 GGCHTPMGCYSQVDEDKIKFIAAY-SHDGKQ-----IRVVIEDDLTKGKEIA----HMAA 289 Query: 300 REILAEVYNGD 310 EI A++ G+ Sbjct: 290 EEIKAKINKGN 300 >UniRef50_Q3YSA8 Porphobilinogen deaminase n=17 Tax=Rickettsiales RepID=HEM3_EHRCJ Length = 298 Score = 365 bits (939), Expect = e-100, Method: Composition-based stats. Identities = 112/293 (38%), Positives = 175/293 (59%), Gaps = 3/293 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LAL Q V + L P + +++V + T GD+ P+ +GGKGLF+KE Sbjct: 3 IRIGTRGSVLALAQTLEVTNLLNRYFPEINIQVVKIKTSGDINNKVPINTIGGKGLFIKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E ALL + D+AVHS+KD+P + GL + + +R P D FVS+ Y S+ +LP + V Sbjct: 63 IEEALLIGKVDLAVHSVKDIPAFYCDGLIIPCVLKRSSPYDVFVSSKYQSIKSLPINATV 122 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR+ QL RPDL + +RGN+ TR+ K D GE+D I+LA AGL R+ + I+ Sbjct: 123 GTSSIRRKVQLNYLRPDLQVIPVRGNIDTRILKSDIGEFDGIVLAEAGLIRINKCNVIKE 182 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L +I L AVGQGA+ ++CR DD + LN H++ + V AER+ + G C P Sbjct: 183 VLDSKIMLSAVGQGAICVQCRADDYNIINKIKVLNCHKSYVCVIAERSFLKTINGSCDTP 242 Query: 246 IGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 + + A+ +D I++ ++ +++ + +AE+ GI + ++L+N Sbjct: 243 LAALAQYVDSDTIYMSCMLSNE--KEMVFSDCYFKECNAEESGIDMGKKLINE 293 >UniRef50_B0K2L4 Porphobilinogen deaminase n=7 Tax=Bacteria RepID=B0K2L4_THEPX Length = 299 Score = 364 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 110/296 (37%), Positives = 172/296 (58%), Gaps = 3/296 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + V+++ TR S LAL Q V +++ E+V + T+GD ++D P++++GGKG+ Sbjct: 1 MKKVIKVGTRSSELALKQTAMVINEIKKFRQDFEFEIVKITTQGDALIDKPVSEIGGKGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKE+E ALL+ D+AVHSMKD+P E P+GL L+ + +REDP+D FVS + L Sbjct: 61 FVKEIESALLKGEIDMAVHSMKDMPYEIPKGLKLMAVLKREDPKDVFVSGDGTQFMDLKE 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ +GTSSLRRQ QL +PD+ I +RGNV TRL K++ D I+L+ AGL RLGLE+ Sbjct: 121 GAKIGTSSLRRQVQLKALKPDIQIVPIRGNVRTRLKKMEELNLDGIVLSAAGLHRLGLEN 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLEG 240 I PP++ +PA QG + +E D+ +E + +T + ER + Sbjct: 181 IITEYFPPDVVVPAPCQGILAVEIAESFDNIFQEFYPYIVDRKTFFEASVERELLKAFGV 240 Query: 241 GCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 C+ P G+YA+ + E + V +++++ E G ++ ++M L EE Sbjct: 241 NCRQPFGAYAQYRKEEDEEKINIKVAYQKENKLLKSEVTGLIEETDKMIEKLIEEF 296 >UniRef50_UPI0000583C22 PREDICTED: hypothetical protein n=1 Tax=Strongylocentrotus purpuratus RepID=UPI0000583C22 Length = 324 Score = 363 bits (933), Expect = 4e-99, Method: Composition-based stats. Identities = 125/315 (39%), Positives = 179/315 (56%), Gaps = 13/315 (4%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 ++R+ +R+S LA+ Q ++V + L HP ++V M T GD I D PLA +G LF Sbjct: 6 EIVRVGSRKSELAMIQTNHVVEMLQKVHPETEFKIVTMETIGDHIQDKPLASIGESNLFT 65 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALP 120 KELE AL + D+ VHS+KD+P P + + ICEREDP DA V + S++ + Sbjct: 66 KELEKALALDEVDMLVHSLKDMPSRLPSNMAIGAICEREDPHDALVLHKKLTGISIETMK 125 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-YDAIILAVAGLKRLGL 179 GS++GTSS+RR QL + P L+ + +RGN+ TRL KLD G+ YD ++LAVAG+ R+G Sbjct: 126 EGSVLGTSSVRRVAQLKRKFPHLVFKDVRGNLNTRLRKLDEGQVYDGLVLAVAGMMRMGW 185 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 E RI L P+I +V QGA+GIE + + R ELL LNH T +R AER + LE Sbjct: 186 EHRISQILKPDICKYSVSQGALGIEIKTKNRRMHELLRQLNHVPTLIRCIAERGLLKTLE 245 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGA------PQDAEQMGISLAEE 293 GGC P+ ++EL + L A + + Q+AE +G+S+A+ Sbjct: 246 GGCSAPVAVHSELEENRHSLDAE---TNEEMKLFSSVIAPWVSQHAMQEAEALGVSVAKG 302 Query: 294 LLNNGAREILAEVYN 308 L + GA IL Sbjct: 303 LFDKGAGPILEAAKE 317 >UniRef50_C3XEZ5 Porphobilinogen deaminase n=3 Tax=Campylobacterales RepID=C3XEZ5_9HELI Length = 328 Score = 362 bits (929), Expect = 1e-98, Method: Composition-based stats. Identities = 146/315 (46%), Positives = 190/315 (60%), Gaps = 12/315 (3%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + L + TR S LALWQA+++K+KL + G V L + T+GD ILD PLAK+GGKGLF Sbjct: 12 EKPLVLGTRGSLLALWQANHIKEKLESL--GFQVVLKTIKTKGDKILDAPLAKIGGKGLF 69 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 KELE LL D AVHS+KDVP+ P L LV+I +RED RD FVS Y + +LP G Sbjct: 70 TKELENELLSGGIDFAVHSLKDVPIAIPPELMLVSITQREDARDCFVSEKYADIASLPQG 129 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 + VGT+SLRR QL R DL +SLRGNV TRL KL GE+DAIILA AGL RL L+ Sbjct: 130 AKVGTTSLRRSMQLKRIRQDLDTQSLRGNVQTRLEKLRKGEFDAIILASAGLNRLDLKDD 189 Query: 183 IRAA--LPPEISLPAVGQGAVGIECRL-------DDSRTRELLAALNHHETALRVTAERA 233 I L +PA+GQG++GIECR D ++L +L+ ++AL ERA Sbjct: 190 IGFISHLQINQFIPAMGQGSLGIECRDPKYSPDFRDQAIMKVLESLHDSKSALCCNIERA 249 Query: 234 MNTRLEGGCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAE 292 L GGCQ PIG +A+++D + I ++ +VG D S+++ R + E + Sbjct: 250 FIQLLGGGCQSPIGIHAQILDSKEIEIQCVVGNLDASKVLTETRVCNKGEVEYALQDMIN 309 Query: 293 ELLNNGAREILAEVY 307 L NG EIL EV Sbjct: 310 TLKKNGVMEILEEVR 324 >UniRef50_Q5HBG1 Porphobilinogen deaminase n=2 Tax=Ehrlichia ruminantium RepID=Q5HBG1_EHRRW Length = 299 Score = 360 bits (925), Expect = 3e-98, Method: Composition-based stats. Identities = 112/298 (37%), Positives = 177/298 (59%), Gaps = 3/298 (1%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M + + TR S LA+ QA VK L P + V++V +VT GD+ L+++GGKG Sbjct: 1 MNSMNVYVGTRGSILAIAQAMEVKKLLYNYFPDINVQIVHIVTSGDINDKISLSEIGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF+KELE ALL D+AVHSMKDVP + L + I +R P D F+S+ Y SL +LP Sbjct: 61 LFLKELEEALLTGTIDLAVHSMKDVPAFYCDSLVIPCILKRSSPYDVFISSKYQSLRSLP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 +++GTSS+RR+ QL + + +RGNV TR+ KL+ G+YD IILA AGL R+ Sbjct: 121 DNAVIGTSSIRRKVQLMRLLSSVQVVPIRGNVDTRILKLEAGQYDGIILAKAGLMRINKT 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 I+ L P++ L AVGQGA+GI+CR +D + +++ LN ++ + V AER+ + G Sbjct: 181 HVIKEVLDPQVMLSAVGQGAIGIQCRANDYKMIDMIKILNCKKSYISVAAERSFMKTVNG 240 Query: 241 GCQVPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 C P+ + A+ ++ +++ ++ + + + + DAE GI++ +L++ Sbjct: 241 SCDTPLAALAKYVNSDTLYMSCMLSNEE--KTVFSDCYFNECDAEISGINMGNDLMDQ 296 >UniRef50_C6XGK7 Porphobilinogen deaminase n=1 Tax=Candidatus Liberibacter asiaticus str. psy62 RepID=C6XGK7_LIBAP Length = 307 Score = 359 bits (923), Expect = 6e-98, Method: Composition-based stats. Identities = 113/297 (38%), Positives = 162/297 (54%), Gaps = 2/297 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGG 58 M RI TR SPLAL A + LM H P + ++P+ T+GD I + L ++GG Sbjct: 1 MEKKPFRIGTRCSPLALAHAFETRSSLMDVHKIPPHNIVIIPLSTKGDRITNRTLTEIGG 60 Query: 59 KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118 KGLF +E+E L+ D AVHS KD+P + +GL + RED RD F+S+ SL Sbjct: 61 KGLFTEEIEKKLISGEIDCAVHSAKDMPTKLLKGLQISAYLPREDIRDVFISHTAQSLKD 120 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 L S++GTSSLRR+ L R D+ + RG + TRL+KL+N + AI+LA AG+KRL Sbjct: 121 LALHSVIGTSSLRRKALLLRWRSDISVIDFRGKIETRLNKLNNNKAHAILLAYAGIKRLK 180 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 E I+ L E P+ GQGA+ IE +++ + +EL+ +NH +T V ERA L Sbjct: 181 KEKVIKEILNIEDFPPSPGQGAICIETHVNNPKAQELVKVINHEDTWDSVNCERAFLAEL 240 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295 +G C+ I +A ++ +V A DG R G DA +G A+ + Sbjct: 241 DGSCKSAIAGFAYCKGSTLYFYGIVLASDGKIFHEVSRNGNRCDAINIGRDAAQYIR 297 >UniRef50_Q2S2A6 Porphobilinogen deaminase n=1 Tax=Salinibacter ruber DSM 13855 RepID=Q2S2A6_SALRD Length = 323 Score = 359 bits (921), Expect = 1e-97, Method: Composition-based stats. Identities = 144/307 (46%), Positives = 192/307 (62%), Gaps = 5/307 (1%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + L + TR S LAL QA+ V+ +L A+ G VEL + TRGD DTP++++G + +F Sbjct: 4 SDPLVLGTRGSELALRQANVVRSRLEAA--GHRVELETITTRGDEATDTPISEIGDEAVF 61 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN--YDSLDALP 120 KEL+ ALL+ D+AVHS+KD+P P GL L I EREDPRDAFV++ L LP Sbjct: 62 TKELDRALLQGGVDLAVHSLKDIPSTVPSGLALAAIGEREDPRDAFVAHPSFDGHLHDLP 121 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ V T+SLRR QL R DL + +RGNV TRL KL ++ ++LAVAGL RLGL Sbjct: 122 EGATVATASLRRTAQLLTWRSDLEVVPVRGNVDTRLEKLGESDWTGMVLAVAGLVRLGLS 181 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLA-ALNHHETALRVTAERAMNTRLE 239 IR + P + +PAVGQGA+GI CR D R+LL L+H + AERA ++ Sbjct: 182 LHIRDRIDPSLIVPAVGQGALGIACREDQDALRDLLRETLHHAPSGHAANAERAFLKKVG 241 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GGCQVP+G++A + DG + L A + A DGS+ R ERR AP+D +G LA +LL G Sbjct: 242 GGCQVPLGAWAHIDDGTLVLDACIAALDGSEHYRDERRCAPEDGAAVGRKLAADLLAMGG 301 Query: 300 REILAEV 306 IL +V Sbjct: 302 DHILDDV 308 >UniRef50_D0NJW2 Porphobilinogen deaminase n=2 Tax=Phytophthora infestans T30-4 RepID=D0NJW2_PHYIN Length = 361 Score = 358 bits (919), Expect = 2e-97, Method: Composition-based stats. Identities = 124/320 (38%), Positives = 174/320 (54%), Gaps = 11/320 (3%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGK--- 59 + +++R+S LA+ Q + V L P L + T GD +LD L+ +G Sbjct: 13 KRTIFVSSRKSQLAMAQTNTVIAMLEERFPDLQFVVGQEDTVGDQVLDRHLSDLGTTTAS 72 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY------ 113 GLF K LE ALL A AVHS+KD+P P GL L I +RE P DA V + Sbjct: 73 GLFTKSLEEALLAKAASFAVHSLKDMPTTLPDGLVLAAITKRESPEDAAVIHPKHKEKGI 132 Query: 114 DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-YDAIILAVA 172 +L LP GS++GTSSLRR+ L + P I+++RGN+ TRL+KLD + YDAII+A Sbjct: 133 KTLQELPEGSVIGTSSLRREALLRSQFPTFEIKTVRGNIQTRLAKLDEHDDYDAIIVAAC 192 Query: 173 GLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232 G +R L RI LP + VGQG++G+ECR DD T E+L + ++A AER Sbjct: 193 GFRRGELGDRIDEILPMDTFGYGVGQGSIGVECRADDEETIEMLKTITDEKSAQLCKAER 252 Query: 233 AMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAE 292 ++ LEGGCQ+ +G A L + + L A V + DG + + G E++G LAE Sbjct: 253 SLLYHLEGGCQIAMGVSATLDEDTLTLNATVLSRDGKESVHETISGPRTQCEELGKQLAE 312 Query: 293 ELLNNG-AREILAEVYNGDA 311 NN AR++L + A Sbjct: 313 RFWNNELARKVLGKTRQKRA 332 >UniRef50_Q4HT06 Porphobilinogen deaminase n=1 Tax=Campylobacter upsaliensis RM3195 RepID=Q4HT06_CAMUP Length = 308 Score = 357 bits (917), Expect = 3e-97, Method: Composition-based stats. Identities = 151/305 (49%), Positives = 201/305 (65%), Gaps = 4/305 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L IATR+SPLALWQ+ +V D L +H G+ V L T+GD++LD+PLAK+GGKGLF Sbjct: 2 KKLIIATRKSPLALWQSEFVADILRKTH-GIEVHLEGFSTKGDILLDSPLAKIGGKGLFT 60 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE A+LEN+A +AVHS+KDVP PQGL L + RED DA +S Y L+ALP + Sbjct: 61 KELENAMLENKAHLAVHSLKDVPSFLPQGLVLAALSVREDDTDALLSELYKDLNALPQNA 120 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGT+SLRR+ QL RPDL I +LRGNV +RL +L GE+DAIILA AG+KRLGLES + Sbjct: 121 KVGTTSLRRKMQLLSLRPDLHIINLRGNVNSRLKRLKGGEFDAIILASAGVKRLGLESEV 180 Query: 184 RAA--LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + + +PA QG +GI+ D + LL LN ++ + T ER LEGG Sbjct: 181 KFIYRFSKDELVPAATQGILGIQS-PDKNEILTLLQCLNDEKSLIESTVERDFIRTLEGG 239 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 CQVPIG AEL+ +I +R+++G PDGS+I+R +R ++ + G LA E + GA+E Sbjct: 240 CQVPIGINAELMGEQITVRSILGLPDGSEILRDKRIILKKNYQGFGERLALEFIKRGAKE 299 Query: 302 ILAEV 306 +L Sbjct: 300 LLKRA 304 >UniRef50_C7N5L0 Porphobilinogen deaminase n=2 Tax=Slackia RepID=C7N5L0_SLAHD Length = 318 Score = 357 bits (917), Expect = 3e-97, Method: Composition-based stats. Identities = 121/313 (38%), Positives = 167/313 (53%), Gaps = 5/313 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + I TR S LALWQ V +M + P + VE+ T GD+ L +PLA++G KGL Sbjct: 1 MPERFVIGTRGSKLALWQTETVGRAIMRAFPEIEVEIRVRNTTGDINLASPLAEIGDKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDA 118 F +ELE LL D+ VHS+KD+ E P+G + + R D RD V SL Sbjct: 61 FTRELETDLLLGEVDMCVHSLKDLETEQPEGCVVAGVLPRADARDVLVCGPRIQAASLAE 120 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 +P GS +GT S RR QL P+++ +RGNV TR++K + +Y+ ILA AG+KR+G Sbjct: 121 VPEGSRIGTGSRRRVAQLKANFPNMVPEGIRGNVDTRVAKAEGDDYEGAILAAAGMKRMG 180 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 E I A LP E +PA GQGA+ +E + R ++ ALN T AER + L Sbjct: 181 YEDHIAAYLPIEDMIPAPGQGAIAMEVLKKNERAYQIARALNDPVTKACTDAERFVLFSL 240 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ--DAEQMGISLAEELLN 296 EGGC PIG++ L DG+ A V + G++ R D M + EL+ Sbjct: 241 EGGCSAPIGAHCRLEDGKYIFDACVLSLGGTKAARCHLEADADSADPMDMAWEVVSELIG 300 Query: 297 NGAREILAEVYNG 309 GAR IL ++ NG Sbjct: 301 EGARAILRDIKNG 313 >UniRef50_Q11XT5 Porphobilinogen deaminase n=8 Tax=Bacteria RepID=HEM3_CYTH3 Length = 312 Score = 354 bits (909), Expect = 2e-96, Method: Composition-based stats. Identities = 125/310 (40%), Positives = 172/310 (55%), Gaps = 4/310 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 ++ +RI TR S LALWQA +V L GL ++V + T GD ILD L+K+G KGL Sbjct: 1 MNKTVRIGTRGSKLALWQAEHVAACLQTK--GLEPQIVIIDTTGDKILDQSLSKIGSKGL 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F +ELE L DIAVHS KD+ G+ ++ I ERE D VS+ Sbjct: 59 FTEELEEQLHAGTIDIAVHSAKDLQTHLKGGMYILAITERELVNDVLVSHKPIDTLKNNP 118 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 I+GTSS RR+ L + P + +RGN+ TR+ K++ G DA++LA AG+ R+G +S Sbjct: 119 DLIIGTSSTRRRALLRKFYPQAKMVDMRGNLQTRIRKMEEGACDAMLLAYAGMHRMGYDS 178 Query: 182 RIRAALPPEISLPAVGQGAVGIECRL--DDSRTRELLAALNHHETALRVTAERAMNTRLE 239 I+ L E +PA GQG + IE D + + A LN T V+AERA LE Sbjct: 179 LIKEKLSLEEFIPAAGQGTLAIEAASTLDKEKAAVIRAVLNDAATETAVSAERAFLRTLE 238 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GGC +P+ + A D + L + + DG++ +R E R DAEQ G+ LA LL +GA Sbjct: 239 GGCSIPVFALAVERDTDYLLTGGIVSLDGTKYLRKEIRFTAADAEQRGVELATVLLKDGA 298 Query: 300 REILAEVYNG 309 EILAE+ G Sbjct: 299 DEILAEIKKG 308 >UniRef50_A6GB01 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=A6GB01_9DELT Length = 322 Score = 354 bits (909), Expect = 2e-96, Method: Composition-based stats. Identities = 138/309 (44%), Positives = 182/309 (58%), Gaps = 6/309 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 LR+ TR S LALWQA+ ++D+L+A+ GL VELV +VT+GD + D PL +VGG GL Sbjct: 9 RKLRLGTRGSALALWQANMIRDRLLAAWGAQGLEVELVRVVTKGDRVTDRPLNQVGGMGL 68 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD--SLDAL 119 FVK LE LL D AVHSMKD+P P+GL L + ER DPRDAF++ +L L Sbjct: 69 FVKGLEDKLLAGEIDFAVHSMKDMPGTLPEGLTLASTPERADPRDAFLAAPGRDVTLATL 128 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 PAGS +GTSSLRR P L I +RGNV TR+ K+ GE DA++LA AGL RLG Sbjct: 129 PAGSRLGTSSLRRGALAKRINPGLEIVPIRGNVPTRMGKIAEGEVDAVLLAAAGLDRLGK 188 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 I L P+ +PA QG + IE R D+ L L H T++ AER+ L+ Sbjct: 189 GEAITERLDPDAFMPAACQGVLAIELRAADTDIAALFEPLGHGPTSIVAAAERSYLATLQ 248 Query: 240 GGCQVPIGSYAELIDG--EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 GGCQVP+ +A L + + + LV PDGS + E G DA Q+G +A E+L Sbjct: 249 GGCQVPLACHARLSEDGRRVRVEGLVVEPDGSTVYASEAEGPVADAAQLGAGVAREVLAA 308 Query: 298 GAREILAEV 306 G + ++ + Sbjct: 309 GGQGVIDRL 317 >UniRef50_A6DBT5 Porphobilinogen deaminase n=1 Tax=Caminibacter mediatlanticus TB-2 RepID=A6DBT5_9PROT Length = 295 Score = 354 bits (909), Expect = 2e-96, Method: Composition-based stats. Identities = 132/296 (44%), Positives = 177/296 (59%), Gaps = 8/296 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 L IATR S LALWQA +VK +L G V+L + T GD ILD PLA +GGKGLF+K Sbjct: 2 KLTIATRGSKLALWQAEWVKKRLENL--GHEVDLKIVTTTGDKILDKPLASIGGKGLFIK 59 Query: 65 ELEVALLENRADIAVHSMKDVPVEF-PQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 E+E ALL A IAVHS+KD P E+ + L + +RE D F+S +++L LP + Sbjct: 60 EVEEALLRGEAQIAVHSLKDFPTEYNKEHFTLAAVPKREAVEDVFLSETFETLAELPHNA 119 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL--ES 181 +VGTSS+RR QL R DL+I LRGNV TR++KL GEYDAIILA AG+KRL L E Sbjct: 120 VVGTSSIRRAMQLKAFREDLVISDLRGNVDTRINKLKKGEYDAIILAYAGVKRLNLIKEV 179 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + L +I +PA+GQGA+GIE + D + E + LN T + VT ER L G Sbjct: 180 KYFEILDTDIMIPAMGQGALGIET-IKDEKVIEAVKPLNDLWTKIEVTIERDFIDELNLG 238 Query: 242 CQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 C P+G A++ +D I ++A + + +++I+ E + E G AEE Sbjct: 239 CHAPVGVNAKIMVDDSIKIKAAILDKN-NKVIKKEMVVPFDEWENAGREFAEEFKE 293 >UniRef50_A8U3E9 Porphobilinogen deaminase n=1 Tax=alpha proteobacterium BAL199 RepID=A8U3E9_9PROT Length = 321 Score = 353 bits (906), Expect = 6e-96, Method: Composition-based stats. Identities = 131/306 (42%), Positives = 178/306 (58%), Gaps = 7/306 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLV--VELVPMVTRGDVILDTPLAKVGGKGLFV 63 L + +R SPLAL Q H V+D+L A+ P L + + + T GD + D PLA++GGKGLF+ Sbjct: 15 LTLGSRGSPLALRQTHEVRDRLAAAWPELAGAIAVQEIRTTGDAVRDRPLAEIGGKGLFI 74 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE+E AL+ + D AVHSMKD+ LV + REDPRDA++S D +D LP+G+ Sbjct: 75 KEIEQALMAGQIDAAVHSMKDMETTIAPASVLVAVLPREDPRDAWLSPIADRVDDLPSGA 134 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +GT+S+RR Q+ RRPDL + RGNV TRL KL GE LA AGL RLG+ + Sbjct: 135 KIGTASVRRAAQVLNRRPDLQVVLFRGNVDTRLRKLAEGEVAGTFLAAAGLSRLGMLDKA 194 Query: 184 RAALPPEISLPAVGQGAVGIECRLD-----DSRTRELLAALNHHETALRVTAERAMNTRL 238 L + LPAV QGA+G++CR D+ R L+ L+ + LRVTAERAM L Sbjct: 195 TRILEVDEMLPAVSQGAIGVQCRDGEASARDAEIRNWLSILDDRPSRLRVTAERAMLATL 254 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 +G C+ PI +A L + L +V + DG A D E +G ++ E +L G Sbjct: 255 DGSCRTPIAGHATLGGARLTLSGMVFSLDGQSSHGAVDTSATDDPEALGRTVGEAILARG 314 Query: 299 AREILA 304 R LA Sbjct: 315 GRNFLA 320 >UniRef50_B3U3W9 Hydroxymethylbilane synthetase n=1 Tax=Oxyrrhis marina RepID=B3U3W9_OXYMA Length = 395 Score = 352 bits (904), Expect = 9e-96, Method: Composition-based stats. Identities = 129/303 (42%), Positives = 168/303 (55%), Gaps = 3/303 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMA-SHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR SPLAL QA V+ + G +++ + T GD ILD LA VGGKGLF K Sbjct: 76 LRIGTRGSPLALAQARDVESRAREQLQQGGEIDICVISTEGDRILDRALADVGGKGLFTK 135 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 EL+ ALL D VHSMKDVP G +V RED RD F+S Y +L LP G++ Sbjct: 136 ELDRALLSGEVDCCVHSMKDVPTTVAPGTEIVAYLPREDTRDVFLSAKYATLADLPDGAV 195 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGT+SLRRQ Q+ + ++++ + RGNV TRL KL G D LA AGLKRLG+ + Sbjct: 196 VGTASLRRQAQILAQ-KNVVVTNFRGNVQTRLRKLAAGTVDCTFLAYAGLKRLGMLAEAT 254 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L LPA+ QGAVGI+ R +D+ R L+ L+H T L V ERA L+G C+ Sbjct: 255 QVLEWSDMLPAIAQGAVGIQIRSNDAALRGTLSQLDHEPTRLAVETERAFLRALDGSCRT 314 Query: 245 PIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 PI A + D + R V + DG Q P D ++G +L ++L E Sbjct: 315 PIAGQAWIGPDSRLAFRGQVLSADGKQRFERVGDCLPCDGPELGKTLGDDLRREAGEEFF 374 Query: 304 AEV 306 AE+ Sbjct: 375 AEL 377 >UniRef50_A6GVP0 Hydroxymethylbilane synthase n=18 Tax=Bacteroidetes RepID=A6GVP0_FLAPJ Length = 308 Score = 352 bits (903), Expect = 1e-95, Method: Composition-based stats. Identities = 111/311 (35%), Positives = 173/311 (55%), Gaps = 8/311 (2%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M ++I TR S LALWQAH+V+ L G +++ + ++GD+ILD PL ++G G Sbjct: 1 MAKKTIKIGTRDSELALWQAHHVEKMLNDL--GHKTKIIAVKSQGDIILDKPLYELGITG 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 +F K L++A++ DIAVHSMKDVP PQG+ + ER + +D V NN +LD L Sbjct: 59 IFTKTLDIAMVNGDIDIAVHSMKDVPTALPQGIVQAAVLERANEKDILVYNN--NLDFLN 116 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 + + T SLRRQ Q + P+ + LRGNV TR+ KL + ++ + A AGL+R+ ++ Sbjct: 117 TQATIATGSLRRQAQWLHKYPNHKVVDLRGNVNTRMQKLQDNNWNGAVFAAAGLERINIK 176 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 + + +PA QGA+ + +D+ + LA LNH ET + ER LEG Sbjct: 177 PE--NYINLDWMIPAPAQGAMMVVAMGNDTYCLDALAELNHIETEITTYIERQFLRTLEG 234 Query: 241 GCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GC PIG+YA D I + ++ + DGSQ I ++ Q+ +Q+G +E+ NG Sbjct: 235 GCTAPIGAYARFNEKDETIHFQGVLFSLDGSQKIEIKKIVEIQEWKQLGYHAGQEIFENG 294 Query: 299 AREILAEVYNG 309 +++ + Sbjct: 295 GVQLMKTIKEK 305 >UniRef50_C4Z552 Porphobilinogen deaminase n=8 Tax=Bacteria RepID=HEM3_EUBE2 Length = 295 Score = 350 bits (900), Expect = 2e-95, Method: Composition-based stats. Identities = 123/291 (42%), Positives = 166/291 (57%), Gaps = 5/291 (1%) Query: 7 RIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66 RI TR S LAL Q+ YVK ++ ++P ELV + T GD + D PLA +G KG FVKE+ Sbjct: 4 RIGTRGSKLALVQSEYVKRRMEEAYPEDTFELVIIKTTGDKVTDKPLAAIGTKGFFVKEI 63 Query: 67 EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126 E ALL D+AVHSMKD+P E GL +RED RD + S LP+G+++G Sbjct: 64 EEALLSGSIDMAVHSMKDMPAECAAGLTFAKAWKREDCRDVLILKTAGSFSELPSGAVIG 123 Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY--DAIILAVAGLKRLGLESRIR 184 T SLRR CQLA RPD+ ++RGNV TR++KL + Y D I+LA AGL RLG S I Sbjct: 124 TGSLRRACQLAMLRPDIQFTAIRGNVDTRINKLMDDSYGLDGIVLAAAGLNRLGRSSEIT 183 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L PE+ +PA QG + IE ++ + + AL+ + AER GGC Sbjct: 184 EYLDPEVVIPAPAQGVLAIETAEVNTELLDKINALSDDNSDREAVAERTFLRLTGGGCHA 243 Query: 245 PIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 P+G++ D G++ + L G D S+I+R E G D+E +G A L Sbjct: 244 PVGAHCVTKDNGDLRMVVLFGNDDCSRILRIEVTGT--DSEAVGHEAARML 292 >UniRef50_B2W5W6 Porphobilinogen deaminase n=2 Tax=Pleosporineae RepID=B2W5W6_PYRTR Length = 399 Score = 350 bits (900), Expect = 2e-95, Method: Composition-based stats. Identities = 128/348 (36%), Positives = 177/348 (50%), Gaps = 45/348 (12%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG----KG 60 + I TR S LA QA V+ L ++P + P++ +GD TPL ++ K Sbjct: 30 PVNIGTRNSVLAQIQARAVERSLKDAYPERTYNICPVIVQGDRDKITPLQQLSQGENAKS 89 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS----NNYDSL 116 L+ ELE L DI VH +KD+P + P L L I EREDPRDA + +L Sbjct: 90 LWTGELESMLESGDLDIIVHCLKDMPTQLPDHLELGAILEREDPRDALLVSPRLPKETTL 149 Query: 117 DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAGL 174 LP G+ +GTSS+RR L + P L LRGNVGTRL+KLD + Y AIILA AGL Sbjct: 150 ATLPQGATIGTSSVRRAATLRKLYPHLKFADLRGNVGTRLAKLDAEDSPYSAIILAAAGL 209 Query: 175 KRLGLESRIRAALPPEI--SLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232 KR+GL++RI L L AVGQGA+GIE R +D +EL++ + T +AER Sbjct: 210 KRMGLDNRITQYLSSTSGGMLHAVGQGALGIEIRKNDEAMKELMSKIRCERTTRACSAER 269 Query: 233 AMNTRLEGGCQVPIGSYAELIDGE------------------------------IWLRAL 262 A+ LEGGC VPIG G+ + +RA+ Sbjct: 270 ALLRTLEGGCSVPIGVETSWKGGKGLSVGPQPAKDYDKHGNAVEEDEPDVDDQELVMRAM 329 Query: 263 VGAPDGSQIIRGERR---GAPQDAEQMGISLAEELLNNGAREILAEVY 307 V + DG + + E ++AE+MG +A+ L+ GA +IL ++ Sbjct: 330 VVSVDGKESVEYEATRKVRNAEEAEEMGREVAKILIEKGADKILEKIN 377 >UniRef50_UPI00006CBE06 porphobilinogen deaminase family protein n=1 Tax=Tetrahymena thermophila RepID=UPI00006CBE06 Length = 362 Score = 350 bits (899), Expect = 4e-95, Method: Composition-based stats. Identities = 123/339 (36%), Positives = 178/339 (52%), Gaps = 32/339 (9%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKL----MASHPGLVVELVPM--------------- 41 + + +IA+R S LAL Q + V D L E+VP+ Sbjct: 16 LKNRKFKIASRSSQLALSQTYEVIDLLVGVKELGLTKENFEVVPISNAPGKNCTLKFKIN 75 Query: 42 ------VTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGL 95 +GD L PL +GG G+F K +EV LL DIAVHS+KD+P + L + Sbjct: 76 ITNKQFTNKGDQNLKDPLYVMGGVGVFTKIVEVELLNKNGDIAVHSLKDLPTIIDERLFI 135 Query: 96 VTICEREDPRDAFVS---NNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNV 152 + + D + + L LP GS++GTSSLRR L R P L ++RGN+ Sbjct: 136 GAVPPLKPRGDVVIFNEKHKGKELKDLPEGSVIGTSSLRRITNLKNRYPHLKYENIRGNL 195 Query: 153 GTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRT 212 TRL+KL+NG+YDAIILA AG+ RLG ++ L E L A GQGA+G++CR DD Sbjct: 196 NTRLTKLENGQYDAIILAEAGVFRLGWIEKVGQFLKQEDFLYAPGQGALGVQCRADDKEA 255 Query: 213 RELLAALNHHETALRVTAERAMNTRLEG---GCQVPIGSYAELIDGEIWLRALVGAPDGS 269 LL+ +N E +RV AER +LEG GC++PI ++E+ID + L V + + Sbjct: 256 IALLSYINQKEPRIRVDAERQFLNKLEGVILGCKLPIAVHSEIIDQTLRLTGQVWSLEAD 315 Query: 270 QIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYN 308 + IR G D + +G+ L+E++ GA EIL ++ + Sbjct: 316 KTIREVIEGHISD-QDLGLKLSEKMKQAGAGEILEKIRS 353 >UniRef50_C6WZF5 Porphobilinogen deaminase n=1 Tax=Flavobacteriaceae bacterium 3519-10 RepID=C6WZF5_FLAB3 Length = 311 Score = 350 bits (898), Expect = 4e-95, Method: Composition-based stats. Identities = 107/307 (34%), Positives = 172/307 (56%), Gaps = 7/307 (2%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 ++I TR SPLALWQA V L + ++ P++++GD L PL +G G+F Sbjct: 10 RSIKIGTRNSPLALWQAREVARHLQNN--NHTTDITPIISKGDKNLSQPLYTLGITGIFT 67 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 K+L++ALL N DIAVHS+KD+P + P+ + ++ + +R+ P+D V + L Sbjct: 68 KDLDIALLNNEVDIAVHSLKDIPTQLPENVEIIAVLQRDYPQDVLVRKKDAATLELHQ-L 126 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 + TSSLRR+ + P +RGNV TRL+KL+ ++DA + ++A ++R+GL Sbjct: 127 KIATSSLRRRAFWLKEFPGTEFSDIRGNVQTRLTKLEENDFDATMFSLAAIERMGLSVD- 185 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + +PA QG V + R +D +EL +NH ET + + ER+ + LEGGC Sbjct: 186 --YEHLPLMIPAPAQGVVAVCARSNDPEIKELFKEINHRETRICIDIERSFLSTLEGGCT 243 Query: 244 VPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 PIG++AE+ D GE+ + + DG I + A + + G LAE++L NG RE+ Sbjct: 244 APIGAFAEINDLGEVRFTGRICSLDGQNCIETDEIFAWNEHDDFGKILAEKILQNGGREL 303 Query: 303 LAEVYNG 309 + E+ + Sbjct: 304 MQEIKSK 310 >UniRef50_A9FDP9 Porphobilinogen deaminase n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=HEM3_SORC5 Length = 300 Score = 349 bits (897), Expect = 6e-95, Method: Composition-based stats. Identities = 152/299 (50%), Positives = 196/299 (65%), Gaps = 4/299 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + L +ATR+S LAL Q+ L A+ P L + + +VT GD D L +GGKGL Sbjct: 1 MPTELTLATRRSALALAQSRAFARSLEAAVPDLSLRELEVVTSGDKTQDRSLQDIGGKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F+KELE ALL+ RAD AVHS+KDVP E L L I REDPRDA V+ + L LPA Sbjct: 61 FIKELEEALLDRRADFAVHSIKDVPAEIAPALCLACIPAREDPRDALVTRSGALLAELPA 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ VGTSSLRR L E RPDL+I +RGNV TRL K+ +G +DA++LA+AGLKRLGLE+ Sbjct: 121 GARVGTSSLRRAVALREARPDLVIEPVRGNVDTRLRKVFDGVFDAVVLALAGLKRLGLEA 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 R L PE+SLPA+GQGA+GIECR D R++L L ET + V+AERA+ +EG Sbjct: 181 RATEVLSPEVSLPAIGQGALGIECRTADDSVRDVLGTLADAETTICVSAERAVMAAVEGS 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR----GAPQDAEQMGISLAEELLN 296 C+ P+ +YA G +WLRAL+ PDGS++ R ERR G ++AE++G L EL Sbjct: 241 CRTPVAAYAVRDGGALWLRALLAEPDGSRLRRAERRLSWPGNTREAERLGADLGAELKK 299 >UniRef50_A3CL78 Porphobilinogen deaminase n=1 Tax=Streptococcus sanguinis SK36 RepID=HEM3_STRSV Length = 306 Score = 347 bits (892), Expect = 2e-94, Method: Composition-based stats. Identities = 126/300 (42%), Positives = 179/300 (59%), Gaps = 7/300 (2%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 V+++ TR+S LA+ Q + D+L A HP LVP T+GD + L ++GGKG+FV Sbjct: 2 KVIKVGTRKSKLAMTQTQQLVDQLKALHPERDFVLVPYTTKGDRLTHVSLQEIGGKGVFV 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALPAG 122 KE+E ALL ++AVHS+KD+P + +G L I +RED RD + +L LP G Sbjct: 62 KEIERALLAGEINMAVHSLKDMPAKLAEGCALGAISQREDVRDCLIFRQAGQTLADLPKG 121 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 S++GTSS+RRQ QL +RPDL + LRGN+ TR+ KL+ GEYDAI+LA+AGLKRLG + Sbjct: 122 SLIGTSSIRRQVQLQAQRPDLAFKPLRGNIDTRIKKLEEGEYDAIVLAMAGLKRLGWLDQ 181 Query: 183 IR---AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 R L + LPA+ QGA+ +ECR +D LLAA+ +TA V ERA+ ++ Sbjct: 182 SRLHIQPLETSLCLPAISQGALAVECREEDEELLSLLAAVQDEKTAAEVAVERAVLAQMN 241 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 C PI ++A+ L A++ DG Q I +G QD +Q+ +L + GA Sbjct: 242 ADCTFPIAAFAQKNGQGYQLEAMLAKEDG-QCIFVSLQG--QDGQQLAEQAVRQLADKGA 298 >UniRef50_Q1V167 Hydroxymethylbilane synthase n=3 Tax=Candidatus Pelagibacter RepID=Q1V167_PELUB Length = 307 Score = 347 bits (891), Expect = 3e-94, Method: Composition-based stats. Identities = 111/300 (37%), Positives = 168/300 (56%), Gaps = 3/300 (1%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVE---LVPMVTRGDVILDTPLAKVG 57 M + + I +R S LAL A ++K++ +E + +VT+GD + D L++VG Sbjct: 1 MKNRKIIIGSRGSKLALIYAEKAREKILKHSKDFGIEEVIIKEIVTKGDQVQDKRLSEVG 60 Query: 58 GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD 117 GKGLF K +EV LLE + DIAVH++KD+P E +GL ER DPR+ +S + L Sbjct: 61 GKGLFSKTIEVELLEKKIDIAVHALKDMPSEETRGLLTDCFLERNDPREILISKDNKHLK 120 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177 L + SI+GTSS RR+ Q+ + R DL + +RGNV TR+ KL YDAIIL+ AG+ L Sbjct: 121 DLASNSIIGTSSYRREFQIKKIRDDLNCKLIRGNVDTRIRKLKENLYDAIILSYAGIDSL 180 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 GL I +P GQG + ++CR +D ELL ++H T + AER + Sbjct: 181 GLNQNISQTFSTSEIIPCAGQGVIALQCRDNDESLIELLKQVDHQSTHSSIKAERNVLKV 240 Query: 238 LEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 LEG C+ +G++A + +I L + + DGS+ + + AE++GI + + L Sbjct: 241 LEGDCETAVGAFANIEGNKINLEVELFSLDGSKRFYLKSSESVDKAEELGIEMGKTLKKM 300 >UniRef50_A0LRF1 Porphobilinogen deaminase n=1 Tax=Acidothermus cellulolyticus 11B RepID=HEM3_ACIC1 Length = 331 Score = 347 bits (890), Expect = 4e-94, Method: Composition-based stats. Identities = 128/313 (40%), Positives = 165/313 (52%), Gaps = 6/313 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +VLR+ TR+S LA Q + L A+ G VE+V + + GD D PL + G G+FV Sbjct: 8 SVLRLGTRRSTLARAQTEEIAGALRAA--GCRVEIVGIQSTGDRHADVPLHEFAGSGVFV 65 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 EL ALL D+ VHSMKD+P L + I R DPRDA V+ L LP G+ Sbjct: 66 AELRAALLRGEVDVVVHSMKDLPTAEIPELAIAAIPRRADPRDALVTGAGCRLAELPTGA 125 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 IVGT S RR QL RPDL IR +RGN+ TRL KL G Y A+I+A AGL RL Sbjct: 126 IVGTGSPRRAAQLRLLRPDLEIRPIRGNLDTRLGKLHAGGYAALIVAAAGLARLHRSEEA 185 Query: 184 RAALPPEISLPAVGQGAVGIECRLDD----SRTRELLAALNHHETALRVTAERAMNTRLE 239 P + LPA GQGA+ +ECR D R +LA L+ T VTAERA+ + Sbjct: 186 AEFFDPTVMLPAPGQGALAVECRRADIADGGRLAGILAGLDDPATRAAVTAERALLAAVG 245 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GC P+G+ + + L A+V P G+ R G P DA +G LA +L+ GA Sbjct: 246 AGCSAPVGALGVVTADTLQLDAVVVDPSGTTAFRRSLTGTPDDASDLGRRLAADLIRAGA 305 Query: 300 REILAEVYNGDAP 312 ++L P Sbjct: 306 DQLLQAPKQTGEP 318 >UniRef50_A2Q9P7 Catalytic activity: 4 porphobilinogen+H(2)O<=>hydroxymethylbilane+4 NH(3) n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2Q9P7_ASPNC Length = 346 Score = 345 bits (887), Expect = 9e-94, Method: Composition-based stats. Identities = 120/324 (37%), Positives = 173/324 (53%), Gaps = 22/324 (6%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG-----KG 60 LR+ TR S LAL QA +V +L ++HPG+ +V RGD +P K G K Sbjct: 12 LRLGTRNSKLALVQAEHVSKELTSAHPGVQFPWQTVVVRGDADKSSPFLKFAGPSDAAKN 71 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-----DS 115 ++ +E+E L D+ VH +KD+P P+ L I REDP DA V Sbjct: 72 IWTEEMETKLCAGELDLLVHCLKDMPTRLPETCTLGAIVYREDPTDALVIKEGLRSQYTD 131 Query: 116 LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAG 173 L LP GS+VGTSS RR+ L R P L + RGN+GTRL KLD+ E + AIILA AG Sbjct: 132 LSQLPPGSVVGTSSTRRKALLRYRYPHLKVEECRGNLGTRLKKLDDPEGPFSAIILATAG 191 Query: 174 LKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERA 233 + R+ LE RI LPP AVGQGA+GIE R +D++T+ ++ + T AER+ Sbjct: 192 MVRINLEDRITKRLPPSEFPYAVGQGALGIEIRKEDAQTKTMVRKIEDLVTRRICLAERS 251 Query: 234 MNTRLEGGCQVPIGSYAELID-------GEIWLRALVGAPDGSQIIRGERR---GAPQDA 283 + L+GGC P+ + + ++ L + P G+ ++ G +DA Sbjct: 252 LLRTLQGGCSSPVAVHCTVEQAPTASSPAQLRLDGTIIHPHGTTLLSERTTAEVGTDEDA 311 Query: 284 EQMGISLAEELLNNGAREILAEVY 307 E +G ++A++LL NG + +L E+ Sbjct: 312 EALGATVAQQLLKNGGQALLEEIR 335 >UniRef50_C0YV01 Hydroxymethylbilane synthase n=1 Tax=Chryseobacterium gleum ATCC 35910 RepID=C0YV01_9FLAO Length = 302 Score = 344 bits (884), Expect = 2e-93, Method: Composition-based stats. Identities = 110/305 (36%), Positives = 167/305 (54%), Gaps = 6/305 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +RI TR S LALWQA V L + + E+VP+V+ GD L+ PL +G G+F Sbjct: 2 KSIRIGTRNSALALWQAREVARHLQNN--NYLTEIVPIVSSGDKNLNQPLYSLGITGVFT 59 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 ++L++ALL + DIAVHS+KDVP + PQ + ++ ER+ P+D + Sbjct: 60 RDLDIALLNDEIDIAVHSLKDVPTQLPQNIEMIAYLERDYPQDILIRKESSRNKEFHE-L 118 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 + TSSLRR+ P +RGN+ TRL KL+ G++DA IL++AG+KR+ +E Sbjct: 119 KLATSSLRRRAFWLRNYPTAEFSDIRGNIQTRLQKLEEGDFDATILSLAGIKRMKMEIDY 178 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 LP + A QG + + D E++ +NH ET + V ER + LEGGC Sbjct: 179 -EMLPL--MISAPSQGVISVAGHTDKPEINEIVRQINHQETQICVEIERNFLSTLEGGCT 235 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 PIG++AE+I +I +A + + DG I + AE G A+ +L NG +E++ Sbjct: 236 APIGAFAEIIGDQIRFKAALCSLDGKNCIAVDENFVYTPAENFGEKYAKVVLENGGKELM 295 Query: 304 AEVYN 308 AE+ + Sbjct: 296 AEIKS 300 >UniRef50_Q0TQG4 Porphobilinogen deaminase n=32 Tax=Clostridium RepID=HEM3_CLOP1 Length = 291 Score = 344 bits (883), Expect = 2e-93, Method: Composition-based stats. Identities = 128/292 (43%), Positives = 170/292 (58%), Gaps = 4/292 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L IATR+S LA Q V + L + + + ++T GD LD L K+GGKGLFVKE Sbjct: 3 LIIATRKSKLAQVQTEKVMELLKEKE-NVDSKKLLVMTEGDRRLDVSLNKIGGKGLFVKE 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E+ALL A AVHSMKDVP E P LV + ERED RDAFVS N +L L G+ + Sbjct: 62 IELALLNKEAHGAVHSMKDVPFELPSEFELVAMPEREDIRDAFVSLNGSTLSNLRKGARI 121 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR QL R DL I +RGNV TR+ K+ D IILA AGLKRLG+E I Sbjct: 122 GTSSIRRAEQLKLFRDDLEIVPIRGNVQTRIKKITEENLDGIILAAAGLKRLGMEDVISD 181 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 P++ LPA+GQGA+GIEC + AL+ E V AER+ L GGC Sbjct: 182 YFDPKVFLPAIGQGALGIECLKGG-EFNDYFKALDSKEVRTTVEAERSFMKVLNGGCHSL 240 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 IG+Y+E+ D ++++ + +I++ + G +D +G LAE++L Sbjct: 241 IGAYSEVKDNDLYMIGTFTVNN--RIVKKDILGNKEDNILLGKKLAEKILGE 290 >UniRef50_C3PNS9 Porphobilinogen deaminase n=15 Tax=Rickettsia RepID=HEM3_RICAE Length = 351 Score = 343 bits (882), Expect = 4e-93, Method: Composition-based stats. Identities = 105/254 (41%), Positives = 155/254 (61%), Gaps = 1/254 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + N +RI TR+SPLAL + V ++ P + E+VP++T GD+I + PL +GGK L Sbjct: 1 MTNSIRIGTRKSPLALIHTNLVIQQIKQFFPDINCEIVPIITSGDLIQNKPLYDIGGKAL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F+KE+E ALL+ + D+AVHS+KDVP P+ L + + EREDPRD FV Y S++ LP Sbjct: 61 FLKEIEQALLDKKIDLAVHSLKDVPGRIPEPLVIAAVLEREDPRDVFVCLKYKSIEELPQ 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG-LE 180 +++G+S++RR+ + + RPDL + RGNV +R+ KL GE DA ILA GLKRL Sbjct: 121 NAVIGSSAVRRKAFIQKIRPDLKVTVFRGNVDSRIKKLMTGEVDATILAYTGLKRLEVFN 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 + LP +GQG + +E R DD+ E+ +NH T + ERA L+ Sbjct: 181 PEYCHLIEYSQMLPCIGQGVIAVEIRKDDNAMLEICNQINHLPTFELIKPERAFLEYLDA 240 Query: 241 GCQVPIGSYAELID 254 C+ PI +Y++ +D Sbjct: 241 NCRTPIAAYSQYLD 254 >UniRef50_C1AA38 Porphobilinogen deaminase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1AA38_GEMAT Length = 309 Score = 343 bits (881), Expect = 5e-93, Method: Composition-based stats. Identities = 151/311 (48%), Positives = 186/311 (59%), Gaps = 6/311 (1%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M+ +RI TR S LAL QA V +L A G+ ELV T GD ILD PL+ +G KG Sbjct: 1 MMTVPVRIGTRSSELALRQARQVAAQLDAR--GVPSELVEYTTLGDRILDRPLSAIGEKG 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLD 117 LF ELE LL R D AVHS+KD+P PQG+ +V + EREDPRDA V SLD Sbjct: 59 LFTAELEADLLAGRIDCAVHSLKDLPTADPQGIIVVALLEREDPRDALVVRAGVDAHSLD 118 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177 LP G+ VGTSSLRR+ QL R DL + LRGNVGTRL KLD G+ DA +LA AGL RL Sbjct: 119 TLPEGARVGTSSLRRRAQLQALRSDLEVCELRGNVGTRLRKLDEGQVDAALLAAAGLHRL 178 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 GL RI A L L A GQGA+ ++ R DD L++L+H T + VTAERA+ Sbjct: 179 GLADRIVAYLDAPEWLSAPGQGAIAVQGRADDEALLSTLSSLDHAPTRVAVTAERALLAA 238 Query: 238 LEGGCQVPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 LEGGCQVPIG+ E + L A++ + DGS +RG + GI LA +L Sbjct: 239 LEGGCQVPIGAAVLEEPEYGTILHAVIVSLDGSSAVRGGYPVDHANPAASGIELARQLRA 298 Query: 297 NGAREILAEVY 307 G +IL+E+ Sbjct: 299 AGGAQILSEIR 309 >UniRef50_A8MDU3 Probable porphobilinogen deaminase n=2 Tax=Thermoproteaceae RepID=HEM3_CALMQ Length = 305 Score = 343 bits (880), Expect = 5e-93, Method: Composition-based stats. Identities = 124/304 (40%), Positives = 180/304 (59%), Gaps = 2/304 (0%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 ++RIATR S L+L Q V D+++ + + +L+ + T GDV L PL ++G KG+F + Sbjct: 2 IIRIATRGSALSLKQTKIVMDRILEFNKDVEFKLIIVKTTGDVDLSKPLYEIGVKGIFER 61 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E+ A+L AD+AVHS+KD+P + L LV R++PRDA VS ++D LP SI Sbjct: 62 EVNQAVLRGEADVAVHSLKDMPAQISNDLTLVMTPPRDNPRDALVSLRQYTVDTLPLNSI 121 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGTSSLRR+ L R D+ ++ +RGNV TR+ KL+NGEYDA+I+A AGL+RL + + + Sbjct: 122 VGTSSLRRRGFLLSLRRDVTVKPIRGNVDTRIRKLNNGEYDALIMAAAGLERLSINANVS 181 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 + PE+ PA GQG +G+ R D ++L + ET AERA +R+ GC V Sbjct: 182 E-ISPELMPPAPGQGIIGVVARRDRDDLIKVLRRSSDEETFKEAAAERAFLSRIGAGCHV 240 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 P+G A L DG V PDG + R ++ E+ G AE+LL N AR ++A Sbjct: 241 PLGGLALLDDGYFDFTYGVVDPDGVEKFINSTRIDARNPEEAGRVAAEDLLRN-ARGLVA 299 Query: 305 EVYN 308 + Sbjct: 300 RLLK 303 >UniRef50_C1ZK04 Porphobilinogen deaminase n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZK04_PLALI Length = 318 Score = 342 bits (879), Expect = 8e-93, Method: Composition-based stats. Identities = 139/315 (44%), Positives = 181/315 (57%), Gaps = 16/315 (5%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 VLRIATR S LALWQA++V D L + P L VELV + T GD + PL + GG+G+F + Sbjct: 3 VLRIATRASQLALWQANFVADSLRSLDPELTVELVHVTTTGDRVQGEPLRQFGGQGVFTR 62 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS----LDALP 120 E++ ALLE RADIAVHS+KD+P GL L + R DA + S L LP Sbjct: 63 EVQAALLEGRADIAVHSLKDLPTVPTAGLELAAVPARAPVADALLLPTGHSGPASLAMLP 122 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GT S RRQ QL RPDL+ +RGN+ TR+ KLD GEY+ +ILAVAGL RLG Sbjct: 123 RGARIGTGSPRRQAQLLRIRPDLVCSEVRGNLDTRIRKLDAGEYEGLILAVAGLSRLGWS 182 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 RI L P PA GQGA+G+ECR D T ++ L +T L V AERA+ LE Sbjct: 183 DRISLILAPPTMFPAAGQGALGLECRHGDEATIRWVSQLEDRQTRLAVDAERAVLRTLEA 242 Query: 241 GCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRG--ERRGAPQD---------AEQMGI 288 GC P+G++A + L A++ APDGS+ + +G A ++G Sbjct: 243 GCHAPVGTWASWKSPETLHLEAILIAPDGSETLAAASSMQGPLSQYGSGNALDAAHELGA 302 Query: 289 SLAEELLNNGAREIL 303 ++A LL GA L Sbjct: 303 NVAHLLLKQGASRYL 317 >UniRef50_A3ZKX4 Porphobilinogen deaminase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A3ZKX4_9PLAN Length = 308 Score = 342 bits (878), Expect = 1e-92, Method: Composition-based stats. Identities = 133/308 (43%), Positives = 185/308 (60%), Gaps = 5/308 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LA WQA++V D+L A G VE++ + T+GDV PL +GG+G+F E Sbjct: 4 IRIGTRGSQLAQWQANWVADQLRAV--GTDVEIIHIATQGDVTQG-PLDLIGGRGVFTTE 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 ++ ALL+NR D+AVHS+KD+P E GL L + R D +++ + LP SI+ Sbjct: 61 IQAALLDNRIDVAVHSLKDLPTEAVVGLRLAAVPARGADGDVLITSKASDVLGLPQESII 120 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT S+RR+ QL R D IR +RGN+ TRL KLD+G YDAIILA AGL+RL L RIR Sbjct: 121 GTGSMRRKAQLLHLRRDFQIRDIRGNLDTRLRKLDDGLYDAIILAEAGLRRLELIERIRH 180 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 +P LPAVGQGA+G+E R DS T +LA LNH ++ V AER+M L GGC P Sbjct: 181 VIPKAQMLPAVGQGALGLEIRERDSATAAMLAPLNHEDSHYSVLAERSMLRNLRGGCLAP 240 Query: 246 IGSYAELI--DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 +G++ + ++L +V + DG + G P AE +G +A++L GA ++ Sbjct: 241 VGAWGRIDPIKQLLFLDGVVVSGDGHHKVTASACGPPNRAEDIGRQVADQLAIQGAERLI 300 Query: 304 AEVYNGDA 311 A + Sbjct: 301 AFARATGS 308 >UniRef50_C4ZFT9 Porphobilinogen deaminase n=1 Tax=Eubacterium rectale ATCC 33656 RepID=C4ZFT9_EUBR3 Length = 338 Score = 342 bits (878), Expect = 1e-92, Method: Composition-based stats. Identities = 113/309 (36%), Positives = 160/309 (51%), Gaps = 39/309 (12%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67 I TR S LAL Q YV DKL ++P + V + T GD+ L K+G KG+FVKE+E Sbjct: 5 IGTRGSKLALVQTDYVIDKLKRAYPDDDFKAVIIKTTGDLEQKKALDKIGSKGIFVKEIE 64 Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127 LL + +AVHSMKD+P E GL +REDPRD V N SLD LP G+++GT Sbjct: 65 DELLSGKIHMAVHSMKDMPDEPAAGLTFAKAWKREDPRDVLVLKNAASLDELPHGAVIGT 124 Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE------------------------ 163 S RR+ QL + RPDL + +RGN+ TRL KL +GE Sbjct: 125 GSKRRKYQLLKLRPDLKVVGIRGNIDTRLRKLYDGEIIYEEVADNTVNNNEIANEKKNKY 184 Query: 164 ----YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAAL 219 D I+LA AG+KR+G +S I + +PA QG + +E R D+++ L AL Sbjct: 185 SEYRLDGIVLAAAGIKRIGRDSEITQYFSEDDMIPAPAQGTLALELRADNAKLMAKLDAL 244 Query: 220 NHHETALRVTAERAMNTRLEGGCQVPIGSYAEL-----------IDGEIWLRALVGAPDG 268 + +T L ER ++ G C +P+ +Y ++ + + L A+ G+ DG Sbjct: 245 SDEKTNLCAGIEREFLKQIGGNCHLPVAAYCDIVSEKDRGNDSNKNNRLKLLAMFGSEDG 304 Query: 269 SQIIRGERR 277 Q+ R E+ Sbjct: 305 KQLARTEQV 313 >UniRef50_A5CDH4 Porphobilinogen deaminase n=2 Tax=Orientia tsutsugamushi RepID=HEM3_ORITB Length = 298 Score = 340 bits (874), Expect = 3e-92, Method: Composition-based stats. Identities = 124/295 (42%), Positives = 161/295 (54%), Gaps = 3/295 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 ++R+ +R S LAL QA V K+ GL ++P+ T GD+I + L +GGKGLF+K Sbjct: 2 IIRVGSRASRLALIQAQAVVQKINDL-LGLNAIIIPIKTTGDLIQNKNLYDIGGKGLFLK 60 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E+E ALL N DIAVHS+KDVP P GL L + ER D D VS + + LP G+I Sbjct: 61 EIEYALLNNTIDIAVHSLKDVPAYLPDGLQLAAVLERGDVGDMLVSKIANKITDLPLGAI 120 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE-SRI 183 VGTSS+RR+ QL RPDL I RGNV TR +K+ N E DA +LA AGL+RL + SR Sbjct: 121 VGTSSVRRRIQLLMLRPDLNIVLFRGNVDTRWNKIINNEVDATVLAAAGLQRLNYDTSRF 180 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 +P LPA+GQGA+ IE R DD L A +NH T + ER L C Sbjct: 181 CNIIPQSEMLPAIGQGAIAIEARKDDKLIMPLCAKINHQLTWQLIQVERGYLKTLNADCN 240 Query: 244 VPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 VPIG A I + ++G + E RG Q +G+ A+ Sbjct: 241 VPIGGIASYIGNNSFEAKFMLGDYNMRYFFYSEVRGKLQHGYDIGVEAAKNFQKR 295 >UniRef50_B3DZQ6 Porphobilinogen deaminase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DZQ6_METI4 Length = 298 Score = 339 bits (871), Expect = 7e-92, Method: Composition-based stats. Identities = 114/296 (38%), Positives = 164/296 (55%), Gaps = 3/296 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L I +R S LAL QA + D L +P L +++ + T GD + P+ + +G+F Sbjct: 2 KPLIIGSRGSRLALIQAQLIVDSLKKEYPLLDIQIRVIKTTGDHLEAQPIRDIDQRGIFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE+E LLE D+AVHS+KD+ VE L + I REDPRD ++S + +L AG+ Sbjct: 62 KEIENKLLEGEIDLAVHSLKDLQVELHPRLVIAAIPPREDPRDCWISLQHPHPSSLQAGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG-EYDAIILAVAGLKRLGLE-- 180 IV T S RR QL +RPDL I +RGNV +RL KL ++ +LA+AG+KRLG++ Sbjct: 122 IVVTGSPRRANQLLRKRPDLRIVPVRGNVESRLRKLRENRQWQGTVLALAGIKRLGIDIS 181 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 S L + LPA GQGA+ ++ R++D T+ L+ LN TA VTAER L G Sbjct: 182 SFFCTPLSMDWMLPAPGQGALALQARIEDKHTQSLVKHLNDFSTACAVTAERVFLHELGG 241 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 GC+ +G+ AE+ + L + + G+ G AE +G LA+ L N Sbjct: 242 GCRTAVGARAEVEGSRLVLEGIWWPQQAIEPKEGKVVGEIHRAEDLGKKLADLLKN 297 >UniRef50_B8MVK7 Porphobilinogen deaminase, putative n=1 Tax=Talaromyces stipitatus ATCC 10500 RepID=B8MVK7_TALSN Length = 413 Score = 339 bits (871), Expect = 7e-92, Method: Composition-based stats. Identities = 120/337 (35%), Positives = 170/337 (50%), Gaps = 36/337 (10%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGL-VVELVPMVTRGDVILDTPLAKVG----- 57 +R+ +R S +AL Q V L +H G + +GD + + Sbjct: 72 KAVRVGSRNSKMALIQTSSVAAALYKAHHGFFTFPVSTHSVQGDRDKTSAFRDLAKAHGN 131 Query: 58 -------GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS 110 K L+ E+E LL D+ VHS+KDVP P G + R DP DA + Sbjct: 132 KQTAADTAKSLWTLEIEARLLAGDIDLIVHSLKDVPTTLPDGCEIGAFPHRNDPTDALLV 191 Query: 111 N---NYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YD 165 Y SL+ LPAGS+VGT S+RR QL P LII+ RGNV TR++KLD + Y Sbjct: 192 KAGLPYKSLEELPAGSVVGTCSVRRTAQLRHYCPHLIIQECRGNVDTRVAKLDANDSPYT 251 Query: 166 AIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETA 225 AI++A AG+ RL LE RI L AVGQGA+GIE R +D + REL+A ++H T Sbjct: 252 AIVVAAAGIVRLNLEHRITQRLSGPAYTYAVGQGALGIEIRKEDQKARELVACIDHWPTR 311 Query: 226 LRVTAERAMNTRLEGGCQVPIGSYAELI---------------DGEIWLRALVGAPDGSQ 270 +R AERA+ L+GGC PIG ++ + +G ++L + PDG Sbjct: 312 VRCLAERALLRFLQGGCSAPIGVHSAFVRTPAKGEPNVNDNHYEGTLYLTGTLLHPDGGM 371 Query: 271 IIRGERRGAP---QDAEQMGISLAEELLNNGAREILA 304 IR +G D+E +G S+ +++L+ G +IL Sbjct: 372 EIRAHEKGQVKCTADSETIGKSVGKKILDLGGAQILD 408 >UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia (class) RepID=B9L0Q4_THERP Length = 560 Score = 339 bits (870), Expect = 8e-92, Method: Composition-based stats. Identities = 125/295 (42%), Positives = 163/295 (55%), Gaps = 4/295 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + +RI +R S LAL Q V ++L P V +VP+VT GD T L +GG G+ Sbjct: 1 MAARIRIGSRGSTLALAQTEEVVERLRRLVPECSVTVVPIVTTGDRDRATSLTVLGGSGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F KEL ALL D+AVHS KD+P + P GL LV + RED RD V++ L LPA Sbjct: 61 FAKELHEALLAGTIDLAVHSAKDLPTQLPPGLVLVAVLAREDARDVLVTSPPRKLGELPA 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ VGTSS RRQ L RPDLI+ +RGNV TRL KL G DA++L AGL+RL Sbjct: 121 GARVGTSSRRRQALLQRARPDLIVVDIRGNVDTRLRKLREGIVDALVLGAAGLRRLSQAD 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + L P+ +PA GQGA+ + R D R ELL+ L+ V ERA G Sbjct: 181 LVAEYLDPDEFVPAPGQGALAVVARESDGRL-ELLSRLDEPLVHEAVAVERAFLAAFGSG 239 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDG---SQIIRGERRGAPQDAEQMGISLAEE 293 C VP+G+YA + + R V PDG SQ + R A + A ++G++LA Sbjct: 240 CSVPLGAYATIAGNRLRFRIAVLLPDGRFISQCLDWPREEAIERARELGLTLATR 294 >UniRef50_Q0BX92 Porphobilinogen deaminase n=1 Tax=Hyphomonas neptunium ATCC 15444 RepID=HEM3_HYPNA Length = 321 Score = 338 bits (869), Expect = 1e-91, Method: Composition-based stats. Identities = 120/298 (40%), Positives = 166/298 (55%), Gaps = 7/298 (2%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPG-LVVELVPMVTRGDVILDTPLAKVGGKGLF 62 LR+ TR SPLAL QAH + D + A+ G E+V T GD + L GGKGLF Sbjct: 11 KRLRLGTRGSPLALAQAHQIADGIRAASAGAYDCEIVAFTTTGDKLTTERLINSGGKGLF 70 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 +EL+ AL D+AVHS+KDVP P G +REDPRD F+S+ S+ LP G Sbjct: 71 TRELDDALSRGELDLAVHSLKDVPSVLPPGQIFAAFPKREDPRDGFLSHGAKSIQDLPEG 130 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 + +GT+SLRR+ Q RPDL + + RGNV TR+ KL+ G DA LA+AGL RLGL Sbjct: 131 ATLGTASLRREAQALALRPDLKVVTFRGNVATRMRKLEEGLADATFLAMAGLTRLGLSEV 190 Query: 183 IRAALPPEISLPAVGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 +P E LPA GQG +G+ R D D+ E+L L+H + + AERA +L+G Sbjct: 191 AT-PIPLEDMLPAAGQGIIGVVTRDDVDTELLEILGQLSHEPSRVAAIAERAFLEKLDGS 249 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQ----MGISLAEELL 295 C+ PI ++ E L V +P G+ RG+ + +G ++A+E++ Sbjct: 250 CRTPIAAHLFDRGDEWQLIGEVLSPGGTTRWRGDGVCRKDATDAQLVLLGRAVAQEII 307 >UniRef50_A2BL26 Probable porphobilinogen deaminase n=2 Tax=Thermoprotei RepID=HEM3_HYPBU Length = 303 Score = 338 bits (869), Expect = 1e-91, Method: Composition-based stats. Identities = 127/299 (42%), Positives = 168/299 (56%), Gaps = 3/299 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LR+ATR S L++ Q + + P L ELV + TRGD+ D P +GGKGLF K Sbjct: 2 KLRVATRGSKLSIAQTMIALEAIKRVEPSLEYELVIVKTRGDIHQDKPFTAIGGKGLFEK 61 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY--DSLDALPAG 122 E+ +A+LE RADIAVHS+KDVP GL L R+ P D V ++ LP+G Sbjct: 62 EVNLAVLEGRADIAVHSLKDVPSAISPGLVLAMTPPRDPPYDVLVVRGGKEKTIWDLPSG 121 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 +IVGTSS RR L R DL+ + LRGNV TRL KL+ G+YDAI+LA AGLKRLG++ Sbjct: 122 AIVGTSSARRVAMLKHVRRDLVFKVLRGNVDTRLRKLEQGQYDAIVLAEAGLKRLGVDIE 181 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 +PP+I PA GQG +G+ S +L + + AERA GGC Sbjct: 182 YWR-IPPDILPPAPGQGIIGVYTLSSRSDILPILEKASDQKAMAEARAERAFLAYAGGGC 240 Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 P+G+YAEL ++ A + +PDGS+ + G P Q+G+ A EL ARE Sbjct: 241 HTPLGAYAELRGNTLYFHAALASPDGSRRVEVRVEGDPDKPTQVGLEAAFELRRLAARE 299 >UniRef50_B5G8F1 Porphobilinogen deaminase n=1 Tax=Streptomyces sp. SPB74 RepID=B5G8F1_9ACTO Length = 314 Score = 336 bits (863), Expect = 5e-91, Method: Composition-based stats. Identities = 128/314 (40%), Positives = 172/314 (54%), Gaps = 13/314 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR SPLAL Q V L P L +E+VP+ T+ D LA++GGKGLFV+E Sbjct: 1 MRIGTRSSPLALAQVEQVSGLLRKFEPDLDIEVVPVTTKADKWQGD-LAQLGGKGLFVRE 59 Query: 66 LEVALLENRADIAVHSMKDVP--VEFPQGLGLVTICEREDPRDAFVSNNY---DSLDALP 120 ++ L + D+AVH MKDVP V P+GL R+D RD + SL LP Sbjct: 60 IDQMLQRGQVDMAVHCMKDVPGDVPMPRGLIFAAYLPRDDVRDVLLVPEGSDVQSLAGLP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD-----NGEYDAIILAVAGLK 175 G+ V TS++RR+ Q+ RPDL + +RG VG+R+ KLD + DA++LA AGL+ Sbjct: 120 PGASVATSAVRRKAQINRVRPDLNVVRVRGLVGSRIDKLDGRKPMDHMLDAMVLARAGLE 179 Query: 176 RLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235 RL L R R LPAVG GA+G+ECR DD LL LN T +TAER M Sbjct: 180 RLDLMHRARQVFEVAEMLPAVGAGALGLECREDDDAVAYLLQQLNDEPTMTEITAERVML 239 Query: 236 TRLEGGCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRG-APQDAEQMGISLAEE 293 L G C PI + DG++ LR +V + DGS+ + G + D +G + E Sbjct: 240 HGLRGHCNSPIAGHCVTDPDGQLSLRGMVFSRDGSKFVHAHFWGESMNDPAVLGSRVCAE 299 Query: 294 LLNNGAREILAEVY 307 LL GAR+I+ + Sbjct: 300 LLRQGARDIIEGIP 313 >UniRef50_A4XK06 Porphobilinogen deaminase n=2 Tax=Clostridia RepID=HEM3_CALS8 Length = 290 Score = 336 bits (863), Expect = 5e-91, Method: Composition-based stats. Identities = 101/293 (34%), Positives = 152/293 (51%), Gaps = 4/293 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 LRI R S L+ Q V K+ G+ E VP+ T+GD+ L G+FV Sbjct: 2 KKLRIGARDSKLSRIQVDIVARKIK-QTLGIECEFVPIKTKGDIDKTKSLKDFKSPGVFV 60 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE+E+ALL D+AVHS+KD+P E +V + EREDPRD VS + L + Sbjct: 61 KEIELALLSREIDLAVHSLKDLPCEMDSNFEIVAVVEREDPRDVLVSKDGVGFYQLKPNA 120 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +GTSSLRR+ L R D+ + ++RGN+ TRLSK+++ D ++LA A LKRL L+S + Sbjct: 121 KIGTSSLRREVHLKNLRQDIQVVNIRGNIETRLSKIESEGLDGVVLAYAALKRLNLDSHV 180 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 P GQGA+ IEC D + +L+ +N + ++ ER + L GGC Sbjct: 181 SYIFDVNEITPCPGQGAICIECLKDSPY-KNILSKINDADAYIQTQFERLVLKFLGGGCH 239 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 IG + + +I+ A + + G ++I+ G D + L+ L + Sbjct: 240 SSIGVFCKTDQDKIYAFASILS--GDKLIKASIEGDKDDFLSLANKLSNMLKS 290 >UniRef50_C7NFP7 Hydroxymethylbilane synthase n=7 Tax=Actinomycetales RepID=C7NFP7_KYTSD Length = 358 Score = 335 bits (861), Expect = 8e-91, Method: Composition-based stats. Identities = 134/329 (40%), Positives = 180/329 (54%), Gaps = 33/329 (10%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 V+R+ TR+S LA Q+ +V D L A G VELV + T GDV PL+++GG G+FV Sbjct: 14 RVVRLGTRRSDLATTQSTHVADALRAR--GHEVELVLVTTEGDVNR-APLSRIGGTGVFV 70 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 L ALL DIAVHS+KD+PV PQ L + + EREDPRDA V+ + +L+ LPAG+ Sbjct: 71 SALRDALLAGEIDIAVHSLKDLPVAQPQELVIAAVPEREDPRDALVARDGLTLETLPAGA 130 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGT S RR+ QL RPDL + LRGNV RL+ + GE DA++LA AGL+RLGL + Sbjct: 131 RVGTGSPRREAQLRVARPDLEVVDLRGNVPRRLATVAEGELDAVVLAGAGLRRLGLTEHV 190 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 L P++ +PA GQGA+ +ECR DD+ + +L L+H T TAERA+ LE GC Sbjct: 191 TQWLEPQVMVPAPGQGALAVECRSDDAESIAMLEPLDHLPTRTATTAERAVLGTLEAGCS 250 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQII------------------------------R 273 PIG+ A + L G DGS+ + Sbjct: 251 APIGALARHDGARVDLMTFAGPRDGSRALLEADCARGVPAGHPADTPDDTPADTPDDSRN 310 Query: 274 GERRGAPQDAEQMGISLAEELLNNGAREI 302 +R A ++G +AE L GA + Sbjct: 311 DDRVALDTAARELGRRVAEALRGGGADVL 339 >UniRef50_Q09899 Porphobilinogen deaminase n=2 Tax=Schizosaccharomyces RepID=HEM3_SCHPO Length = 336 Score = 335 bits (861), Expect = 8e-91, Method: Composition-based stats. Identities = 126/314 (40%), Positives = 176/314 (56%), Gaps = 16/314 (5%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG---GKGLFVK 64 I TR+S LA+ Q+ ++++L +P L ++ T GD IL L + K L+ + Sbjct: 9 IGTRKSKLAVIQSEIIREELEKHYPHLEFPIISRDTIGDEILSKALFEFKRQLAKSLWTR 68 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALPA 121 ELE L+ N+ I VHS+KD+P E P G+ + I +R P DA V +Y ++ LP Sbjct: 69 ELEALLVTNQCRILVHSLKDLPSEMPDGMVIACIPKRSCPLDAIVFKAGSHYKTVADLPP 128 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAGLKRLGL 179 GS+VGTSS+RR+ LA P L +RGNVGTRL+KLD + +D ++LA AGL RLGL Sbjct: 129 GSVVGTSSIRRRALLARNFPHLRFVDIRGNVGTRLAKLDAPDSQFDCLVLAAAGLFRLGL 188 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 + RI L AVGQGA+ +E R DD E+L L H ET AERA+ RL+ Sbjct: 189 KDRIAQMLTAPFVYYAVGQGALAVEVRADDKEMIEMLKPLQHQETLYACLAERALMKRLQ 248 Query: 240 GGCQVPIGSYAEL-----IDGEIWLRALVGAPDGSQIIRGE---RRGAPQDAEQMGISLA 291 GGC +PIG ++ I L V + DG + G + ++AE++GI++A Sbjct: 249 GGCAIPIGVQTDVLAISNSSYRISLLGTVLSADGLRAAFGNAEAVVSSEEEAEELGITVA 308 Query: 292 EELLNNGAREILAE 305 LL NGA IL E Sbjct: 309 LALLKNGAGPILEE 322 >UniRef50_C8WIZ2 Porphobilinogen deaminase n=2 Tax=Coriobacteriaceae RepID=C8WIZ2_EGGLE Length = 327 Score = 334 bits (857), Expect = 3e-90, Method: Composition-based stats. Identities = 137/318 (43%), Positives = 183/318 (57%), Gaps = 13/318 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LALWQAH+V D L A+ PG+ V + + T+GD IL L+K+G KGLF KE Sbjct: 4 MRIGTRGSKLALWQAHHVADLLRAASPGMDVSVEVVKTKGDRILGVALSKIGDKGLFTKE 63 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE AL + R D+ VHSMKDVP P+GL L R D RD V+ + + LPAGS V Sbjct: 64 LEQALFDGRVDVCVHSMKDVPTALPEGLALAGCLIRADARDVLVAASGTTFAGLPAGSRV 123 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT +LRR QL R DL +RGN+ TR++K+ +G DA++LA AG++R+G + + Sbjct: 124 GTGALRRLSQLRAVRDDLDYVEVRGNLDTRIAKVRDGALDAVVLAAAGIERMGWSAEVAE 183 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 A + +PAVGQGA+G+E R DD RT A + T V AER + L+GGCQVP Sbjct: 184 AFSVDTVVPAVGQGAIGLEVRADDERTARACAQVRCAATDACVAAERHVMRALDGGCQVP 243 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGE-------------RRGAPQDAEQMGISLAE 292 IG+YA +G + L A VG+ DGS ++R A ++A + E Sbjct: 244 IGAYARYEEGLLVLDAFVGSLDGSHVLRSRLSAASQPPNDTDAVEAAVREARALAQRAVE 303 Query: 293 ELLNNGAREILAEVYNGD 310 E GAR +L V Sbjct: 304 EFEAQGARAVLDAVRAAG 321 >UniRef50_A8SQW4 Putative uncharacterized protein n=1 Tax=Coprococcus eutactus ATCC 27759 RepID=A8SQW4_9FIRM Length = 350 Score = 334 bits (857), Expect = 3e-90, Method: Composition-based stats. Identities = 115/314 (36%), Positives = 164/314 (52%), Gaps = 26/314 (8%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 +++ TR S LAL Q V L P + ++V M TRGD L + GGK +F Sbjct: 39 KKTVKVGTRGSKLALAQTELVIKALNERFPQIDFQMVTMSTRGDRDTSRALLEFGGKAVF 98 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 V+E E A+L+ DIAVHS KD+P+E +GL + R P+D F+ + S D Sbjct: 99 VEEFEEAILKGDIDIAVHSAKDMPMEIMEGLTISGTLPRACPQDVFIYKSGRSFDR-NDS 157 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL--- 179 +VGTSSLRRQ Q+ + P+ + ++LRGNVGTR+ KL++GEYDAIILA AGL+RLG+ Sbjct: 158 FVVGTSSLRRQYQIRDMYPNAVCKNLRGNVGTRIQKLEDGEYDAIILAAAGLERLGVIED 217 Query: 180 -------------ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETAL 226 + L E LPA QG + IE R +++ A+N E Sbjct: 218 KGNDSTECFEVHKDELTFRYLSTESMLPAACQGIIAIETRTSGEAY-DMVRAINDTEAYT 276 Query: 227 RVTAERAMNTRLEGGCQVPIGSYAELIDGEIWL---RALVGAPDGSQ-----IIRGERRG 278 ++T ERA+ +RL GC PIG Y+EL + L + + D + I R G Sbjct: 277 QLTCERAVLSRLNAGCHEPIGVYSELKGKHMKLSLMKVDAASSDKEKDEEIQIHRKTVEG 336 Query: 279 APQDAEQMGISLAE 292 + EQ+ +L + Sbjct: 337 NTSEWEQLVEALIK 350 >UniRef50_A8MGE4 Porphobilinogen deaminase n=30 Tax=cellular organisms RepID=HEM3_ALKOO Length = 296 Score = 333 bits (856), Expect = 4e-90, Method: Composition-based stats. Identities = 113/293 (38%), Positives = 160/293 (54%), Gaps = 5/293 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +R+ +R+S LA+ Q+ V + + P + +ELV M T GD+ LD L K+GGKGLF+K Sbjct: 2 KIRVGSRESKLAVKQSEIVIEAIRKYDPNIEIELVTMKTTGDIKLDQTLDKIGGKGLFIK 61 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 EL+ AL ++R DI VHS KD+P+ + L +V + +REDPRD V ++ Sbjct: 62 ELDQALYDDRVDITVHSFKDMPMAIDEYLPIVAVSKREDPRDVLVLPK--TVKEPDFSKP 119 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +G SS RR+ QL E P + +RGNV TRL KLD GE+ AI LA+AGLKRLGLE RI Sbjct: 120 IGCSSFRRKIQLQEIYPHCSVEPIRGNVLTRLEKLDRGEFSAITLALAGLKRLGLEERIS 179 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 LPA QG + ++ R L+ + E AER+ L GGC Sbjct: 180 RIFEVTEILPAACQGVIVVQARKG--FDVSFLSDFHDKEAWDISMAERSFVRTLNGGCSS 237 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 P+ +Y E+ D + L L S + + GA + E+MG +LA ++ Sbjct: 238 PVAAYGEIKDNYLTLTGLYVDSSNS-VHKKTITGARKQGEEMGFNLALQMKGE 289 >UniRef50_B9XN63 Porphobilinogen deaminase n=1 Tax=bacterium Ellin514 RepID=B9XN63_9BACT Length = 332 Score = 332 bits (853), Expect = 7e-90, Method: Composition-based stats. Identities = 127/329 (38%), Positives = 172/329 (52%), Gaps = 38/329 (11%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG---K 59 + + IATR S LAL QA+ V + ++ P L +EL + T GD + LAK G K Sbjct: 6 NKPIFIATRGSALALAQANAVLSQCRSAFPKLDIELKIIKTTGDKLQKASLAKEGESLPK 65 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSL--- 116 GLF KELEVALL ADIAVHS+KD+P E P GL L + +R D RD V + + L Sbjct: 66 GLFTKELEVALLNGDADIAVHSLKDLPTELPTGLILGAVSKRADVRDVLVYRDAEYLRSQ 125 Query: 117 ---------------DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN 161 P G+ V TSS RR+ QL +R DL + +RGNV TRL KL N Sbjct: 126 PGKSNRRGFTPKLAIKDFPPGATVATSSTRRKAQLLAQRGDLNVVEIRGNVATRLEKLAN 185 Query: 162 -GEYDAIILAVAGLKRLGL--------------ESRIRAALPPEISLPAVGQGAVGIECR 206 E DA +LA AGL+RL E + L ++ LP VGQ A+G+E R Sbjct: 186 QPELDATVLAAAGLERLNFKITAEGKLAGEGIPEGLLATILDFDVMLPCVGQAALGMEIR 245 Query: 207 LDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAP 266 +D+R +E+ LNH ET V AER+ + + GGCQ P+ +YAE+ ++ +RA Sbjct: 246 ENDARIQEICDRLNHPETHACVLAERSFLSGMGGGCQSPVAAYAEIAGDQLQMRAASFRE 305 Query: 267 DGSQIIRGERRGAPQDAEQMGISLAEELL 295 + R + +A +G LA +L Sbjct: 306 --TSARRAVGGKSINEAVALGQELAAKLK 332 >UniRef50_A4QB59 Porphobilinogen deaminase n=15 Tax=Corynebacterium RepID=HEM3_CORGB Length = 302 Score = 332 bits (853), Expect = 9e-90, Method: Composition-based stats. Identities = 118/304 (38%), Positives = 171/304 (56%), Gaps = 8/304 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 L+I TR S LA QA ++D+L + G EL + T GDV + +P+ ++G G+F + Sbjct: 2 TLKIGTRGSKLATTQAGTIRDQLK--YFGRDAELHIVTTPGDVNM-SPVERIG-VGVFTQ 57 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L L D+AVHSMKD+P LV + R D R+A ++ + +L LP G+ Sbjct: 58 ALRDVLHAGECDVAVHSMKDLPTAADPRFHLV-VPTRADSREALIARDGLTLAELPEGAK 116 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGTS+ RR QL RPDL I LRGN+ TR+ K+ +GE DA++LA AGL R+G++ R Sbjct: 117 VGTSAPRRISQLKAIRPDLEILPLRGNIDTRMGKVTSGELDAVMLAYAGLTRVGMQDRAT 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 +I +PA QGA+ IECR DD+ T L L H +T + AER + RLE GC Sbjct: 177 EVFDADIIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVLNRLEAGCTA 236 Query: 245 PIGSYAELI---DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 P+ ++A L + L A V A DGS + G E++G +A++L++ GA Sbjct: 237 PVAAHATLDGYSGDTMTLTAGVYALDGSDQLVFSAEGDGARPEELGELVAQQLIDAGAAN 296 Query: 302 ILAE 305 +L + Sbjct: 297 LLGD 300 >UniRef50_Q82P95 Porphobilinogen deaminase 2 n=14 Tax=Actinomycetales RepID=HEM32_STRAW Length = 314 Score = 332 bits (852), Expect = 1e-89, Method: Composition-based stats. Identities = 124/305 (40%), Positives = 167/305 (54%), Gaps = 4/305 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI +R SP+AL Q V+ +L A HP E+V + T GD + L+KV GKG F KE Sbjct: 10 IRIVSRDSPMALAQVARVRAELAALHPRTRTEVVAVKTTGDKWMGD-LSKVDGKGAFTKE 68 Query: 66 LEVALLENRADIAVHSMKDVPV--EFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 ++ ALL AD+AVH +KDVP P G +R+D RDA V +LD LP G+ Sbjct: 69 VDAALLAGEADLAVHCVKDVPADRPLPAGTMFAAFLKRDDIRDALVHPGGLTLDELPPGT 128 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +GTSS+RR QLA P L RGN RL KL GE DA++LAV+GL+R+G E I Sbjct: 129 RIGTSSVRRVAQLAAAYPHLECVPFRGNANRRLEKLAAGEADALLLAVSGLERIGREDVI 188 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 L PE +P +G G + ++CR D+ E ++ L T TAER L+G C Sbjct: 189 TEVLEPETMMPPIGAGILALQCREGDTGLIETISELGDPGTHREATAERMFLHVLQGHCN 248 Query: 244 VPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 PI YA +GE+ LRA V DG ++ D +G S+A LL GARE+ Sbjct: 249 SPIAGYARTERNGELSLRASVFTLDGKTVLNAHEWAGRLDPATLGTSVAVALLRQGAREL 308 Query: 303 LAEVY 307 + ++ Sbjct: 309 IDDIP 313 >UniRef50_C1F251 Hydroxymethylbilane synthase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F251_ACIC5 Length = 312 Score = 332 bits (851), Expect = 1e-89, Method: Composition-based stats. Identities = 139/322 (43%), Positives = 176/322 (54%), Gaps = 37/322 (11%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLA----KVGGKGL 61 +RI +R S LALWQA+++ +L G V + + T GD + A ++GGKG+ Sbjct: 2 MRIGSRGSQLALWQANHIAARLRTL--GHEVTIEIIRTTGDALQHVTFAKVSTELGGKGI 59 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F KE+E AL E R D+AVHS+KD+P + L I ER DPRDA +S Y SL +LP Sbjct: 60 FTKEIEEALREGRIDLAVHSLKDLPTDLDPAFTLAAIPERVDPRDALLSARYTSLASLPH 119 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ VGTSS RR+ QL R DL + RGNV TR+ K+ G+ DAIILA AGL+RLGL Sbjct: 120 GACVGTSSERRRAQLLVHRSDLRFQEFRGNVDTRIRKMVEGQADAIILASAGLERLGLTE 179 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 R L PEI PA GQGA+ IE R DD+ T +LA+L+H T VTAER L GG Sbjct: 180 YRRECLAPEILCPAAGQGALAIETRADDAETLAILASLDHSATRYAVTAERTALASLGGG 239 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ-------------------- 281 CQVPIG + A V DG+ I+G GA Sbjct: 240 CQVPIGIHC----------APVPGADGAYAIQGVVAGAAAKAASSAAHPVIRVAFEHQQG 289 Query: 282 -DAEQMGISLAEELLNNGAREI 302 + +G LAEELL GA+ Sbjct: 290 LSPQALGRQLAEELLRQGAQPF 311 >UniRef50_Q8TXC8 Probable porphobilinogen deaminase n=1 Tax=Methanopyrus kandleri RepID=HEM3_METKA Length = 298 Score = 332 bits (851), Expect = 1e-89, Method: Composition-based stats. Identities = 120/299 (40%), Positives = 172/299 (57%), Gaps = 3/299 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHP-GLVVELVPMVTRGDVILDTPLAKVGGKG 60 + +R+ATR S LA+ Q V + L P + VE+V +RGDV+ D PL K+G KG Sbjct: 1 MSETIRVATRSSRLAIIQTREVIELLERESPRDVEVEIVKTKSRGDVVRDRPLHKLGEKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 +FVKE++ +LE +ADIAVHS KDVP + + + R DPR+ VS + L LP Sbjct: 61 VFVKEVDRLVLEGKADIAVHSAKDVPSVVDYPVDVAAVPPRRDPRECLVSRHGG-LKELP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGTSS RR+ Q+ RPDL + +RGNV TR+SK+ EYDA +LA GL RLG+ Sbjct: 120 RGATVGTSSPRRRAQILLERPDLKVEPMRGNVDTRVSKVRRREYDAAVLAKVGLDRLGMT 179 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 S + PE +P GQGA+ I CR DD R + LL ++ ++ + V E+A+ L Sbjct: 180 SEVSEVYDPEEFVPPAGQGALMITCRKDDDRVKRLLEVVDDEKSRVEVETEKAVVRELGV 239 Query: 241 GCQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GC P+G + + L + DGS + RG+P+D + +S A E+L++G Sbjct: 240 GCSEPVGVHVRARDGDHVRLVLGLFEEDGSCGHVLKMRGSPEDVVREAVSQAREVLSDG 298 >UniRef50_A0DD68 Chromosome undetermined scaffold_46, whole genome shotgun sequence n=2 Tax=Paramecium tetraurelia RepID=A0DD68_PARTE Length = 306 Score = 331 bits (850), Expect = 2e-89, Method: Composition-based stats. Identities = 124/312 (39%), Positives = 171/312 (54%), Gaps = 13/312 (4%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTR-GDVILDTPLAKVGGKG 60 + LRIATR S LA+ Q +YV +L E++ + GDV L PL ++ G Sbjct: 1 MQRQLRIATRSSALAMAQTNYVISELKQ-----ECEIIKVSNEVGDVNLQDPLYQMPTVG 55 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLD 117 +F K++E LLE +AD+AVHS+KD+P L L + E D + N Y SL Sbjct: 56 VFTKQVEQYLLEQKADVAVHSLKDLPTIIDAQLHLAAYTKFEQRGDVVLLNKKYNYKSLS 115 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177 LP G VGTSSLRR + R P L + ++RGN+ TR+ KLD G+YDAIILA AG+ RL Sbjct: 116 ELPDGLKVGTSSLRRIATIRSRYPKLNLINIRGNLNTRIQKLDEGQYDAIILAKAGILRL 175 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 GL +I L + L A Q A+GI+CR DD T L LN + R AER Sbjct: 176 GLAEKISFDLDEKEFLYAPAQAALGIQCRKDDLETIGRLQILNDTDAQKRCVAERMFLNL 235 Query: 238 LEGGCQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 LEGGC++PI Y+E DG+++++ V A DGS++I E E +G L E++ Sbjct: 236 LEGGCRLPIAVYSECREDGQVYIKGRVLAVDGSKVIEDEA---LDHFEIVGQILCEKIKV 292 Query: 297 NGAREILAEVYN 308 G E++ + Sbjct: 293 LGGVELIESLKQ 304 >UniRef50_B8GXG1 Porphobilinogen deaminase n=8 Tax=Caulobacteraceae RepID=HEM3_CAUCN Length = 322 Score = 331 bits (850), Expect = 2e-89, Method: Composition-based stats. Identities = 132/315 (41%), Positives = 176/315 (55%), Gaps = 17/315 (5%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMAS----------HPGLVVELVPMVTRGDVILDTPLA 54 +RI R S L+L Q+ ++ ++ + L+P+VT GD I D L Sbjct: 6 PIRIGARGSKLSLAQSGLMQARIAHALGVPAGASKDEIEAAAPLIPIVTSGDRIQDRRLM 65 Query: 55 KVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD 114 ++GGKGLF KE+E ALL+ R D AVHS+KD+P E P GL L EREDPRDAF+S+ + Sbjct: 66 EIGGKGLFTKEIEEALLDGRIDCAVHSLKDMPAELPPGLVLAATPEREDPRDAFISHVCE 125 Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174 L+ LP G+ +GT+SLRRQ Q RPDL I LRGNV TRL+KL+ GE DAI+LA +GL Sbjct: 126 RLEDLPKGARLGTASLRRQAQALHVRPDLEIVMLRGNVDTRLAKLERGEADAILLAQSGL 185 Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234 RLGL R+ L P+ PA GQGA+ IE R +D L A+ +T + V AER Sbjct: 186 NRLGLGHLTRSWLDPDACPPAPGQGALVIETRAEDIG-APWLEAVRCRQTTIAVAAERGA 244 Query: 235 NTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGA------PQDAEQMGI 288 LEG C+ IG+ A L + + PDG+Q R E +A G+ Sbjct: 245 LLALEGSCRTAIGARAILDGARLSMIVEALTPDGAQRFRREGDITLTGADDIAEARAFGL 304 Query: 289 SLAEELLNNGAREIL 303 +L E+ G I+ Sbjct: 305 TLGAEVRAAGGDAII 319 >UniRef50_B0D5Q2 Predicted protein n=1 Tax=Laccaria bicolor S238N-H82 RepID=B0D5Q2_LACBS Length = 340 Score = 331 bits (850), Expect = 2e-89, Method: Composition-based stats. Identities = 118/316 (37%), Positives = 172/316 (54%), Gaps = 10/316 (3%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + I R S LA QA V+ +L P E+ I + + + GG L+ Sbjct: 16 QKAIVIGCRPSTLAKIQAELVRSRLKVLFPASRFEISSKKFPQPEIGTSQITERGGASLW 75 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLDAL 119 ELE AL + DI VHS+KDVP + +G ++ + ERED RD V + +L+ L Sbjct: 76 TTELEDALFDGDIDILVHSLKDVPTKLKEGCEIIHVLEREDRRDCLVVKDGLPYRTLEEL 135 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAGLKRL 177 PAGS+VGT S+RR Q+ R P L+I+ +RGN+ TRL KLD+ + Y A+ILA AGL RL Sbjct: 136 PAGSVVGTGSVRRVAQMKRRYPLLVIKDVRGNIDTRLQKLDSPDLPYTALILASAGLLRL 195 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 L RI + L P IS PAVGQG +G E R D++ + +++ L + V AERA+ Sbjct: 196 SLHDRITSYLSPPISYPAVGQGCLGAEFRSADTKVKAMVSRLEVWQDGWAVRAERALLWV 255 Query: 238 LEGGCQVPIGSYAELIDGEI--WLRALVGAPDGSQIIRGERRG---APQDAEQMGISLAE 292 LEGGC P+G ++ I +++ +PDGS+ I E G + ++ ++G A Sbjct: 256 LEGGCAFPVGIWSSWSGDNIASESLSVMTSPDGSEEITVETTGVVASVEEVLELGKQAAR 315 Query: 293 ELLNNGAREILAEVYN 308 LL G R I+ ++ Sbjct: 316 SLLEKGGRGIIVDLRA 331 >UniRef50_D0J8N1 Porphobilinogen deaminase n=2 Tax=Blattabacterium RepID=D0J8N1_BLASP Length = 310 Score = 331 bits (849), Expect = 2e-89, Method: Composition-based stats. Identities = 99/312 (31%), Positives = 153/312 (49%), Gaps = 7/312 (2%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 ++ ++RI TR SPLA+ QA V+ L G L + + GD+I + PL K G+ Sbjct: 1 MNKIIRIGTRNSPLAISQAIEVQKVLHRL--GYCSHLFFIKSEGDLIQNIPLYKFKKVGI 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS-LDALP 120 F + L LL + D+AVHS+KDVP P+ + L +R D + + L Sbjct: 59 FTRNLTDVLLSGKIDMAVHSLKDVPTSLPEKIVLSAYLKRGSFSDLLIYQGSSNFLLNSK 118 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 +++ T SLRR+ R P I LRGN+ TRL KL N + I A GL+RLGL Sbjct: 119 IEAVIATGSLRRRAFWKNRYPHHTIVDLRGNINTRLKKLYNNSWKGAIFAKVGLERLGLL 178 Query: 181 SRIRAALP--PEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 + + + +P+ GQG + + R D+ L L+ T L ER L Sbjct: 179 NDLEGFNFKVLDWMIPSPGQGIIVVSTRKDNEWIHYLTKELDDRNTRLSANIERQFLKTL 238 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GGC PIG++A + + I+ ++ + DG Q IR ++ G + +G A+E+L G Sbjct: 239 GGGCVTPIGAHAIIKNKIIYFTGILFSLDGMQKIRKKKIGT--NYNVIGYQCAKEILEEG 296 Query: 299 AREILAEVYNGD 310 ++IL + + Sbjct: 297 GKKILENMRIKN 308 >UniRef50_C6XKH7 Porphobilinogen deaminase n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XKH7_HIRBI Length = 323 Score = 330 bits (848), Expect = 3e-89, Method: Composition-based stats. Identities = 110/299 (36%), Positives = 152/299 (50%), Gaps = 7/299 (2%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPG-LVVELVPMVTRGDVILDTPLAKVGGKG 60 +++I R SPLA+ QA + + +E+ T GD +LD L GGKG Sbjct: 17 STQIVKIGARGSPLAVQQAEDFAARFKEIVGNTVEIEIHTFTTSGDQLLDKRLQDAGGKG 76 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF +EL++A L R DI VHS+KDVP P GL + REDPRDA ++ LP Sbjct: 77 LFTRELDIAQLSGRIDIVVHSLKDVPTVLPDGLQMGCYLPREDPRDALFGKVG-NIKDLP 135 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GT+SLRR Q RPDL I RGNV TRL KL+ G+ DA +LA AGL RLG+ Sbjct: 136 HGATLGTASLRRSAQALALRPDLKIVMFRGNVQTRLRKLEEGQADATLLAAAGLNRLGMT 195 Query: 181 SRIRAALPPEISLPAVGQGAVGIE-CRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 + +P E LPA GQG V + + ++ E+ + AERA RL+ Sbjct: 196 DKAAGFMPKEEMLPACGQGIVCTTLTNNAEDWIFKACLQIDVLESRIAAIAERAFLKRLD 255 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRG----APQDAEQMGISLAEEL 294 G C+ PI + + + +R V A DGS+ + A +G L E++ Sbjct: 256 GSCRTPIAGHLSFNETGVDMRGEVLADDGSKRWFSQMSLDTIPDENQAASLGFELGEKV 314 >UniRef50_B6W7F3 Putative uncharacterized protein n=1 Tax=Anaerococcus hydrogenalis DSM 7454 RepID=B6W7F3_9FIRM Length = 318 Score = 330 bits (846), Expect = 5e-89, Method: Composition-based stats. Identities = 103/309 (33%), Positives = 155/309 (50%), Gaps = 12/309 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 ++I +R S LAL QA+ VKD L GL ++V + T+GD I D + ++ KG+FV+E Sbjct: 2 IKIGSRASKLALIQANMVKDILEKE--GLEAQIVEISTKGDRIRDRKIDQLNSKGVFVRE 59 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALPAGSI 124 +E LL+ DIAVHS+KD+P + L + EDPRD FV + + +D L ++ Sbjct: 60 IEEKLLDKTIDIAVHSLKDMPSQIDDRLIFTPPLKGEDPRDCFVGKDVFKKMDDL-NNAL 118 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGT S RR CQ ++ +++RGNV TR+ K+ + D +ILA +GL R GL+ I Sbjct: 119 VGTGSNRRVCQGKNHFSNIKFKAIRGNVETRIKKVQSENLDGVILAKSGLIRAGLDGEIN 178 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L P I P+ QG +GIE R +D + E+ + +T R+ ERA L C Sbjct: 179 FDLDPHIFTPSPCQGILGIEIRKEDKKLFEIFKKNSDEKTLFRMETERAFQKELGADCST 238 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 P+G + E+ +I L + +I G + + LA L Sbjct: 239 PMGIFTEIDHDKITLTGSMAFDKDDRINYERVSGNISERIHLAQKLARTLKKK------- 291 Query: 305 EVYNGDAPA 313 Y + P Sbjct: 292 -SYKKNNPC 299 >UniRef50_Q7UPN0 Porphobilinogen deaminase n=1 Tax=Rhodopirellula baltica RepID=HEM3_RHOBA Length = 337 Score = 330 bits (846), Expect = 5e-89, Method: Composition-based stats. Identities = 127/332 (38%), Positives = 182/332 (54%), Gaps = 27/332 (8%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 LRIATR+SPLA+WQA +V L G E+VP+V++GD + P+ GLF Sbjct: 9 TTRLRIATRESPLAMWQAEHVAKLLKKH--GFQTEIVPLVSKGDTDM-RPIDGTRQVGLF 65 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS------- 115 K ++ AL+++ AD+AVHS+KD+P E L + RE DA V + Sbjct: 66 TKRIQQALVDDEADVAVHSLKDLPTEPDSRFVLAAVPPRESVLDALVFADNSPHLESQTG 125 Query: 116 ----LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAV 171 LD LP G+ VGT S RR QL + RPDL + +RGNV TRL+KL+ GE+DAI+LA Sbjct: 126 AESPLDYLPQGARVGTGSTRRLAQLKQLRPDLEVLPIRGNVQTRLAKLNAGEFDAIVLAH 185 Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231 AG+ RL + P + +PA GQGA+GIE R DD+ + +A LN L TAE Sbjct: 186 AGILRLEMTDLPHRLFPLDEMIPAPGQGALGIEVRSDDAGAMDAIANLNDAAARLAATAE 245 Query: 232 RAMNTRLEGGCQVPIGSYAELI----DGEIWLRALVGAPDGSQIIRGERRGA-------- 279 R + + L GGC PI +A+L E+ LRA+V + DG Q ++ + R Sbjct: 246 RKVLSELHGGCLAPIACHAKLETSNHGTELCLRAIVMSADGEQRLQEDARITVQPNDADL 305 Query: 280 -PQDAEQMGISLAEELLNNGAREILAEVYNGD 310 +A ++G +A+ L + GA ++++ V Sbjct: 306 HVAEAHELGTLVAKRLRDKGADKLISTVRENH 337 >UniRef50_B2IAW6 Porphobilinogen deaminase n=4 Tax=Alphaproteobacteria RepID=B2IAW6_BEII9 Length = 337 Score = 328 bits (842), Expect = 1e-88, Method: Composition-based stats. Identities = 138/306 (45%), Positives = 179/306 (58%), Gaps = 5/306 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 LR+ TR SPLAL QAH + D+L +H V + + T GD+I D PL+ GGKGLF Sbjct: 19 LRLGTRGSPLALAQAHELADRLARAHGFAKEAVAITIIRTSGDMIQDRPLSLAGGKGLFT 78 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KEL+ AL+E D+AVHS KD+P P+ L + RED RD ++S LP GS Sbjct: 79 KELDQALIEGMVDLAVHSAKDLPTILPEDLIIAGYLPREDVRDVWISPKAGHPRDLPPGS 138 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +VGT+SLRR L RPDL +R LRGNV TRL+KL GE DA +LA+AGL+RLGL + Sbjct: 139 VVGTASLRRGALLKRLRPDLEVRLLRGNVETRLAKLAAGEVDATLLALAGLRRLGLADKA 198 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 L E LPA GQGA+GI R DD+ T LLA + T + + AER T L+G C+ Sbjct: 199 TQVLAIEDFLPAAGQGAIGITTRRDDAATLALLAPILDPATHVALAAERGFLTVLDGSCK 258 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 PIG++A + ++ LR +V PDGS+ G + + A EL AR IL Sbjct: 259 TPIGAHATVEHDQVTLRGIVLRPDGSEWFEACESGPLESGS---LEAARELGETAARAIL 315 Query: 304 AEVYNG 309 A + G Sbjct: 316 ARLPEG 321 >UniRef50_Q46CH0 Probable porphobilinogen deaminase n=7 Tax=Euryarchaeota RepID=HEM3_METBF Length = 316 Score = 328 bits (842), Expect = 2e-88, Method: Composition-based stats. Identities = 113/304 (37%), Positives = 164/304 (53%), Gaps = 7/304 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG-GKGLFVK 64 + I TR S LAL QA V L A G+ L + T GD D PL V G G FV+ Sbjct: 1 MIIGTRGSQLALAQAETVARLLKAK--GVETSLKIIKTSGDRFTDRPLHAVSSGVGAFVR 58 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 EL+ +LE + DIAVHSMKD+P P L V + +R+ P D ++ + LD L SI Sbjct: 59 ELDEVMLEGKIDIAVHSMKDMPTIRPPTLPTVAVLKRDTPFDLLLTYDGTPLDELSEQSI 118 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSSLRR Q+ RPDL+ + LRGN+ TRL KL G+YD I+LA AGL+R+G E Sbjct: 119 IGTSSLRRAAQIKRYRPDLVTQDLRGNIDTRLRKLKEGKYDGILLAKAGLERMGWELE-G 177 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L P+ P+ QG + + R + + ++ L+H ++ + ER + + L GGC Sbjct: 178 EILSPDFFCPSPNQGTIAVVTRAE-TEAEAAVSRLDHTDSRIATEIERILISELGGGCTT 236 Query: 245 PIGSYAELIDG--EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 PIGSYAE++ ++ +RA V + DG + + + L L++ G +++ Sbjct: 237 PIGSYAEIMPDRKKLHVRAEVLSLDGEETVGINEFIPMAGGIEKARELGSSLVHMGGKKL 296 Query: 303 LAEV 306 E Sbjct: 297 ADEA 300 >UniRef50_C4QMG7 Hydroxymethylbilane synthase (Porphobilinogen deaminase, putative) n=1 Tax=Schistosoma mansoni RepID=C4QMG7_SCHMA Length = 411 Score = 327 bits (839), Expect = 3e-88, Method: Composition-based stats. Identities = 117/302 (38%), Positives = 160/302 (52%), Gaps = 25/302 (8%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 NV+R+ +R+S LAL Q + L +P ++ E+V M T GD ILD L+K+G K LF Sbjct: 8 NVVRVGSRRSNLALLQTGMAVNLLQKQNPHILFEVVEMATVGDKILDVSLSKIGDKSLFT 67 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS---NNYDSLDALP 120 KELE ALL D+ VHS+KDVP P GL L + R P D + L LP Sbjct: 68 KELENALLSGEVDLVVHSLKDVPSTLPSGLVLGCVFARVSPEDVVLMAPHYRGRKLSDLP 127 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--------------NGEYDA 166 GS VGTS++RR L + P L S+RGN+ TRL+KLD + YDA Sbjct: 128 IGSTVGTSAVRRVATLTRKYPHLKFVSIRGNLNTRLAKLDTPPASKDNCCSGNPSPSYDA 187 Query: 167 IILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETAL 226 IILA AG++R+G RI L + AV QGA+ ECRL D+ +LL+ ++ AL Sbjct: 188 IILAKAGVERMGWSHRIDQVL-TDSF-YAVSQGALACECRLVDNFIMDLLSHIHDESAAL 245 Query: 227 RVTAERAMNTRLEGGCQVPIGSYA--ELIDG----EIWLRALVGAPDGSQIIRGERRGAP 280 AER++ +L+GGC +PIG + L ++ L A + + DG + I Sbjct: 246 TTIAERSLMRQLDGGCSIPIGVRSDLVLKGDLNYYQLTLHANILSVDGGKSIERSASVVF 305 Query: 281 QD 282 D Sbjct: 306 PD 307 >UniRef50_C5RMN3 Porphobilinogen deaminase n=1 Tax=Clostridium cellulovorans 743B RepID=C5RMN3_CLOCL Length = 300 Score = 327 bits (838), Expect = 4e-88, Method: Composition-based stats. Identities = 113/301 (37%), Positives = 168/301 (55%), Gaps = 8/301 (2%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + ++RI TR+S LAL Q + V D + HP + E+V M T+GD ILD L GGKG Sbjct: 1 MKKIIRIGTRKSKLALMQTNIVIDAIKKKHPEINCEVVEMSTKGDEILDKSLLSFGGKGA 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS-NNYDSLDAL- 119 FV E E A+ D+AVHS KD+P++ GL +V + +REDPRD V+ NN D+++ Sbjct: 61 FVSEFEKAIKSGEIDLAVHSAKDMPMDLLTGLKIVAVTKREDPRDVLVTANNKDTINDFN 120 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 ++GT+SLRR+ Q+ ++ + LRGNV RL KL +GEYD IILA AGLKRLGL Sbjct: 121 KTNKLIGTTSLRRKLQIKRLLNNVDTKDLRGNVQRRLEKLISGEYDGIILAAAGLKRLGL 180 Query: 180 ESRIR---AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236 R L E +PA GQG + +E R + L ++++ E + ER + Sbjct: 181 LDDERINLNYLSVEDFIPAGGQGIIAVEGRAE-EEFSFLKDSIHNEEAMYSLEVERYVMK 239 Query: 237 RLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 +L GC PIG+Y+ + I+L + ++ R + + ++ ++ L EE+L Sbjct: 240 KLNAGCNEPIGAYSFIDKDTIFLD--IIYEHNGKVSRKKGSDSIENRLKLTEKLVEEILQ 297 Query: 297 N 297 Sbjct: 298 E 298 >UniRef50_O29026 Probable porphobilinogen deaminase n=1 Tax=Archaeoglobus fulgidus RepID=HEM3_ARCFU Length = 289 Score = 327 bits (838), Expect = 4e-88, Method: Composition-based stats. Identities = 111/294 (37%), Positives = 163/294 (55%), Gaps = 11/294 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 L + TR S LAL Q + V ++L + VE+ + T GD++ D PL + G G FV+ Sbjct: 2 KLIVGTRGSKLALAQTNKVAERLKERY---EVEIRIVKTAGDIMKDKPLYEFKGMGAFVR 58 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L+ AL E + D+AVHS KDVP + +G + + ER+ P D +S + +L+ L G++ Sbjct: 59 ALDTALAEGKVDVAVHSFKDVPSQRVEGTVVAAVIERDSPCDVLISRDGSTLEELDEGAV 118 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI- 183 VGTSSLRR+ QL+ R DL +LRGN+ TRL KL G YDAI++A AGLKRLGL+ + Sbjct: 119 VGTSSLRRRAQLSRLRGDLRFENLRGNLDTRLRKLREGNYDAIVVAEAGLKRLGLDREVE 178 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 PPE+ +P QG + I R + +L+A LN +T L ERA+ L GC Sbjct: 179 YQPFPPEVIVPPANQGIIAIATRKGEE---DLVAFLNDEKTWLEAMVERAVIKELGVGCA 235 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 VP+G YAE + L + + +R E + + A + + ++L Sbjct: 236 VPVGVYAE-AQSRVRLICEILD---KKYLRVEEKLSKDTAVEEAAEIGKDLRKE 285 >UniRef50_D1BFI8 Hydroxymethylbilane synthase n=4 Tax=Actinomycetales RepID=D1BFI8_SANKS Length = 312 Score = 327 bits (838), Expect = 5e-88, Method: Composition-based stats. Identities = 126/309 (40%), Positives = 173/309 (55%), Gaps = 14/309 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LRI TR S LAL Q V D L G VE+VP+ T GD +L L+++GG G+FV Sbjct: 7 LRIGTRSSLLALTQTGTVADDLRRL-TGRPVEIVPVTTDGD-VLTGSLSQMGGTGVFVTA 64 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L ALL++R D+AVHS+KD+P GL V R+DPRDA S L LP G+ V Sbjct: 65 LRAALLDDRCDVAVHSLKDLPTAGVLGLQHV-TPVRQDPRDALCSRAGHRLADLPHGARV 123 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--DNGEYDAIILAVAGLKRLGLESRI 183 GT S RR QL RPDL + +RGN+ TRL ++ + G+ DA++LA AGL R+G E I Sbjct: 124 GTGSPRRAAQLRLVRPDLDVVDIRGNIDTRLGRVHPETGDLDAVVLAAAGLNRIGREHAI 183 Query: 184 RAALPPEISLPAVGQGAVGIECR----LDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 + PA GQGA+ +E R +D L+ T+L V AERA+ RLE Sbjct: 184 TELISVTDMAPAPGQGALAVETRSSLLEEDPVVARAFDQLDDPATSLSVLAERALLARLE 243 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-----GAPQDAEQMGISLAEEL 294 GC P+G++A + DG + L A+V PDGS+ +R + + +A +G ++A+ Sbjct: 244 AGCAAPVGTHATVSDGLLTLHAVVARPDGSEQLRHNQSTEVADTSTAEAVALGEAVADHF 303 Query: 295 LNNGAREIL 303 L GA + Sbjct: 304 LALGAASFI 312 >UniRef50_C2FZW8 Porphobilinogen deaminase n=2 Tax=Sphingobacterium spiritivorum RepID=C2FZW8_9SPHI Length = 528 Score = 326 bits (836), Expect = 6e-88, Method: Composition-based stats. Identities = 112/311 (36%), Positives = 158/311 (50%), Gaps = 24/311 (7%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 ++ L I TR S LA+WQA+++KD+L A+ G+ EL + T+GD+I L K+ GKG Sbjct: 1 MNRKLIIGTRGSQLAMWQANHIKDRLAAA--GIDSELKVIKTQGDIIQHLRLDKLEGKGF 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY----DSLD 117 F KELE LL + D+AVHS KD+P P GL + + ERE P + + Sbjct: 59 FTKELEEELLSSTIDLAVHSHKDLPTVNPPGLIIAAVSERESPAELLIVLKDCVDIKKRL 118 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKR- 176 +L + VGTSS RR+ QL RPDL LRGN+ TR+ KL + YDAIILA AG++R Sbjct: 119 SLKHNATVGTSSNRRKAQLLSLRPDLEFDDLRGNLQTRIQKLRDENYDAIILAKAGVERI 178 Query: 177 -LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235 + L +PP +PA QG + I+ R D E L +++ E A + ER + Sbjct: 179 DMDLSDFYVEEIPPVELIPAPAQGVLAIQIRESDQELFEALQVIHNKEVAEVIAVERKVL 238 Query: 236 TRLEGGCQVPIGSYAELIDGEIWLRALVGA-----PDGSQIIRGERRGAPQDAEQMGISL 290 + GC P+G Y +G+ V PD I R G + Sbjct: 239 NLFDAGCHAPLGCYCRKSEGKYEAWTSVAETSDEFPDRLYIQRDSTEG-----------M 287 Query: 291 AEELLNNGARE 301 AEE+ A++ Sbjct: 288 AEEIFTKFAKD 298 >UniRef50_A4CHM3 Porphobilinogen deaminase n=4 Tax=Bacteroidetes RepID=A4CHM3_9FLAO Length = 315 Score = 325 bits (835), Expect = 1e-87, Method: Composition-based stats. Identities = 121/318 (38%), Positives = 167/318 (52%), Gaps = 18/318 (5%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + LRI TR S LALWQA V+D+L A+ G ELVP+ + GD++LD PL ++G G+ Sbjct: 1 MSRALRIGTRDSELALWQAQTVRDRLEAA--GHRAELVPVKSTGDLVLDKPLYELGITGI 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F K L+VALL D+AVHSMKDVP P+G+ + ER RD V + P Sbjct: 59 FTKTLDVALLREDIDLAVHSMKDVPTALPEGICQAAVLERASARDVLV-HKGLGFLDGP- 116 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 + T SLRR+ Q R P + LRGNV TRL L +D I A AGL+R+GL Sbjct: 117 -GTIATGSLRRKAQWLNRYPAHQVTGLRGNVNTRLKLLRENSWDGAIFAQAGLERIGLLP 175 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 L + LPA QGA+ + R D+ RE L+H ++AL V ER LEGG Sbjct: 176 DNAEPL--DWMLPAPAQGAMLVVARTSDTAAREAARPLHHEQSALEVAVEREFLRTLEGG 233 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER-RGAPQ----------DAEQMGISL 290 C PIG+ DG++ L + + DG + R R G+ + DA + G + Sbjct: 234 CSAPIGARVHAADGQLHLEGGLFSLDGKKAFRVTRHTGSLEAGGTGDARFQDAGEFGAAC 293 Query: 291 AEELLNNGAREILAEVYN 308 A E+L++G ++ + Sbjct: 294 AREILDSGGAVLMESIRK 311 >UniRef50_B3RTQ8 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RTQ8_TRIAD Length = 314 Score = 325 bits (834), Expect = 1e-87, Method: Composition-based stats. Identities = 120/338 (35%), Positives = 172/338 (50%), Gaps = 64/338 (18%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M + V+RI TR+S LA+ Q H V D L HP +E+V M T GD +LD L ++G Sbjct: 4 MEETVVRIGTRKSQLAMIQTHSVVDALREIHPKARIEIVTMDTIGDRVLDKALPEIGQTN 63 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF K+LEVAL +N+ D+ +HS+KDVP P+GL + I Sbjct: 64 LFTKDLEVALTDNKIDLIIHSLKDVPSTLPEGLAIAAI---------------------- 101 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGL 179 G+++GTSSLRR QL R P L ++RGN+ TRL KLD G YDA++LA AG++ Sbjct: 102 -GNVIGTSSLRRIAQLKRRFPHLKFENVRGNLNTRLKKLDESGIYDALVLAGAGVE---- 156 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 L P+ L A+GQGA+GIE R +D +T L++A ++ + AERA L+ Sbjct: 157 -------LTPDECLYAIGQGALGIEIRKNDKKTFSLISAYTDFDSLVCNAAERAFLRFLD 209 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ------------------ 281 GC VPIG Y E + ++ + V + DGS+ ++ Sbjct: 210 KGCSVPIGVYTEFTENKLKITGAVFSLDGSKRVQYSDECTISGLNAKDDCESNYESLSSI 269 Query: 282 -----------DAEQMGISLAEELLNNGAREILAEVYN 308 +AE++G +AE +L N E+LAE Sbjct: 270 LCPSEMCNSLIEAERLGKYVAEMILKNHGGEVLAEARQ 307 >UniRef50_Q47LA7 Porphobilinogen deaminase n=3 Tax=Actinomycetales RepID=HEM3_THEFY Length = 320 Score = 324 bits (832), Expect = 2e-87, Method: Composition-based stats. Identities = 127/319 (39%), Positives = 177/319 (55%), Gaps = 11/319 (3%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M R+ TR+S +A Q+ V + L A G+ VELV + + GD I L ++GG G Sbjct: 1 MSTTPARLGTRRSTMATNQSRRVAEILTAR-TGVPVELVLITSFGD-ITRAHLTQLGGTG 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 +FV L ALL + AVHS+KD+P +G+ L + ER+DPRDA + + LP Sbjct: 59 VFVSALRDALLAGEVEFAVHSLKDLPTAPTEGIVLAAVTERDDPRDALCARDGLKFADLP 118 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGT S RR QLA RPDL +RGN TRL K+ +GE DA++LA AGL R+G Sbjct: 119 PGATVGTGSPRRVAQLAALRPDLRYVPIRGNAETRLGKVASGELDAVVLAYAGLHRVGRL 178 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDD-SRTRELLAALNHHETALRVTAERAMNTRLE 239 + + LPA GQGA+ +ECR D + L A++H T VTAER + LE Sbjct: 179 DDVTDVFDVDQVLPAPGQGALAVECRTADFTGPLRYLTAVDHLPTRAAVTAERVILAELE 238 Query: 240 GGCQVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQD-------AEQMGISLA 291 GC P+G+YAE + + + LRA V A DGSQ +R E+ + A +G LA Sbjct: 239 AGCAAPVGAYAEFVAEDRLRLRAAVVATDGSQAVRAEQTVTVTEFPDAVQAATALGRQLA 298 Query: 292 EELLNNGAREILAEVYNGD 310 +++ GA +I+A+ G Sbjct: 299 HDMIEQGADQIVADAAAGR 317 >UniRef50_C9M5W1 Hydroxymethylbilane synthase n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M5W1_9BACT Length = 714 Score = 324 bits (832), Expect = 2e-87, Method: Composition-based stats. Identities = 115/295 (38%), Positives = 160/295 (54%), Gaps = 7/295 (2%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 LR+A+R+S LA+ Q+ V ++L + G VE++P TRGD + D L GGKGLFV Sbjct: 424 RPLRLASRESELAMAQSRLVAERLHEA-TGFDVEIIPFRTRGDAVADRRLESAGGKGLFV 482 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE A+L +AD+AVHS+KD+P P GL + +R+ D V + + Sbjct: 483 KELERAILSGQADLAVHSLKDMPSSCPDGLAFAALMDRQTAFDCLVLRPGLTGRPV---- 538 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +GTSS RR Q D LRGN+ TRLSKLD GE+DA+ILA AGL+RLGL+ R+ Sbjct: 539 RIGTSSARRIAQGRALFSDAQFVPLRGNLRTRLSKLDGGEFDALILAEAGLRRLGLQERV 598 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + +P+ GQG + ++C D +L++ L+ AERA RL GGC Sbjct: 599 SRVFSADQMIPSAGQGTLAVQCPFDGP-VFDLVSQLDEPAVRTCCLAERAFIDRLNGGCT 657 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 P G+YA + I + L PDG + G+ G D + LA+ L G Sbjct: 658 APHGAYARVDGETIEMIGLYVRPDGKT-LSGKISGPAADGPSLAAELADRLKRRG 711 >UniRef50_Q4T5L1 Chromosome undetermined SCAF9206, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4T5L1_TETNG Length = 385 Score = 324 bits (831), Expect = 3e-87, Method: Composition-based stats. Identities = 134/383 (34%), Positives = 191/383 (49%), Gaps = 85/383 (22%) Query: 13 SPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLE 72 S LA Q V +KL +P + +E+V M T GD ILDT L+K+G K LF KELE AL Sbjct: 1 SQLARIQTDSVAEKLKELYPDVHLEIVAMSTTGDKILDTALSKIGEKSLFTKELENALER 60 Query: 73 NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALPAGSIVGTSS 129 N D+ VHS+KD+P P G + + +RE+P DA V + +LDALPA S++GTSS Sbjct: 61 NEVDLVVHSLKDLPTSLPPGFTIGAVLKRENPHDAVVLHPKNAGKTLDALPAHSVIGTSS 120 Query: 130 LRRQCQLAERRPDLIIRSL------------------------RGNVGTRLSKLDN-GEY 164 LRR QL +R P L + + RGN+ TRL KLD ++ Sbjct: 121 LRRAAQLKKRFPHLDFKDIVSSERCFLPVQPGHRCFFLSSRSQRGNLNTRLKKLDEKEDF 180 Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224 AIILA AGL+R+G ++RI L PE + AVGQGA+ +E R D+ E+++ L+ +T Sbjct: 181 AAIILAAAGLRRMGWDNRISQILEPEDCMYAVGQGALAVEVRAKDADILEMVSVLHDPDT 240 Query: 225 ALRVTAERAMNTRL----------------------------EGGCQVPIGSYAELIDGE 256 LR AERA L EGGC VP+ + ++ D + Sbjct: 241 VLRCIAERAFLKHLVQHTHTHTHTHTHTRSLAVAHWNLFCLQEGGCSVPVAVHTKVKDSQ 300 Query: 257 IWLRALVGAPDGSQIIRGERR--------GAPQD---------------------AEQMG 287 ++L V + DGS ++ + G+P + AE++G Sbjct: 301 LYLTGAVYSLDGSDSLKETMQTSVAAPADGSPDEVDECARVGVTANKIPGEAQDRAERLG 360 Query: 288 ISLAEELLNNGAREILAEVYNGD 310 + LA+ LL+ GA+EIL + Sbjct: 361 VDLAKLLLSKGAKEILTVARQLN 383 >UniRef50_A8AAB4 Probable porphobilinogen deaminase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=HEM3_IGNH4 Length = 304 Score = 324 bits (831), Expect = 3e-87, Method: Composition-based stats. Identities = 113/295 (38%), Positives = 158/295 (53%), Gaps = 7/295 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILD--TPLAKVGGKGLF 62 ++IA R S L+L Q L+ P L E++ + T GD LAK G GLF Sbjct: 2 KIKIAARGSKLSLKQVSMFTSYLLKFFPDLEYEVITVKTTGDKANAPFEELAKRGLTGLF 61 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALPA 121 KE+ A+LE +AD+AVHS+KD+P E L + R+ P D +S + LP Sbjct: 62 EKEVNKAVLEGKADVAVHSLKDLPTELDPRLEIAAFLPRDPPYDVLISRAGNYDIFDLPK 121 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 GS+VGTSS RR+ + RPDL+++ LRGNV TRL KL GEYDAI+LA AG+ RLGL + Sbjct: 122 GSVVGTSSARRKALIKNLRPDLVVKDLRGNVDTRLEKLRRGEYDAIVLAEAGVSRLGL-N 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 L + P+ GQG + R S +LL +++ ++ TAER + GG Sbjct: 181 VDYVRLDWRLFPPSPGQGIIVAVTRKG-SEISDLLKSISDVKSEKLATAERTVLKEFGGG 239 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 C V +G+ A I LRA V +P G + + E G + E++G+ AE L Sbjct: 240 CFVALGAIAFEEGSLIRLRATVLSPSGRERVDVELIG--KGPEEVGMRAAERLKA 292 >UniRef50_D2RH82 Porphobilinogen deaminase n=2 Tax=Archaeoglobaceae RepID=D2RH82_ARCPR Length = 292 Score = 323 bits (830), Expect = 4e-87, Method: Composition-based stats. Identities = 107/296 (36%), Positives = 161/296 (54%), Gaps = 9/296 (3%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + + + TR S LAL Q V ++L G VE+ + + GD++ D PL + G G Sbjct: 1 MSERVVVGTRGSKLALAQTSKVVERLKEE--GYSVEIRIIKSTGDIMKDKPLYEFKGSGA 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FV+ LE AL+ D+AVHS KD+P +G+ + + ER+ P DAF++ N +SL+ + Sbjct: 59 FVRALEHALVRGEIDVAVHSYKDIPSNMLEGVTVSAVLERDSPYDAFIARNGESLEEIKP 118 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 +++GTSSLRR+ QL R DL +LRGNV TRL KL G YDAI+LA AG++RLGL Sbjct: 119 NAVIGTSSLRRRAQLKLYRSDLRFENLRGNVDTRLRKLREGLYDAIVLAEAGIQRLGLNV 178 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + LP E +P QG + ++ R+ + +L+ +NH ET + ER + L G Sbjct: 179 KY-QRLPIERFVPPANQGIIAVQTRVGEE---DLVKFMNHEETWIEAEVERIVMKTLGVG 234 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 C +P G YAE ++ L V DG + + + + A + +AE Sbjct: 235 CAIPAGIYAECRG-KVRLIVQVIR-DGRE-FKVIEELSRESAIEEAREIAENFREE 287 >UniRef50_C6XST0 Porphobilinogen deaminase n=2 Tax=Pedobacter RepID=C6XST0_PEDHD Length = 526 Score = 323 bits (830), Expect = 4e-87, Method: Composition-based stats. Identities = 115/270 (42%), Positives = 157/270 (58%), Gaps = 8/270 (2%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L I TR S LALWQA+++KDKL A G+ EL + T+GD IL+ L K+ GKG F Sbjct: 2 KRLIIGTRGSDLALWQANFIKDKLAAI--GVEAELKIIKTQGDKILNLRLDKLEGKGFFT 59 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRD-AFVSNNYDSLD---AL 119 KELE LL DIAVHS KD+P P GL + + EREDP + + + S++ +L Sbjct: 60 KELEEELLGGTIDIAVHSHKDLPTVHPAGLTIAAVTEREDPSELLLILKDCVSINHKLSL 119 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG- 178 G++VGTSS RR+ QL RPDL I LRGNV TR+ KL + +YDAI+LA AG+ RL Sbjct: 120 KKGAMVGTSSNRRKAQLLALRPDLNIEDLRGNVPTRIQKLRDEDYDAILLARAGVNRLNI 179 Query: 179 -LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 L + +PA QGA+ I+ R +++ ++L +NH ETA + ER + Sbjct: 180 DLSEFHVEVVDTTELVPAPAQGALAIQIRENENELFDILQQINHSETAEEIAIERKVLNL 239 Query: 238 LEGGCQVPIGSYAELIDGEIWLRALVGAPD 267 EGGC +P+G Y + DG+ + D Sbjct: 240 FEGGCHMPLGCYCKKEDGQYEVWTSKAETD 269 >UniRef50_A3MLK5 Porphobilinogen deaminase n=155 Tax=Proteobacteria RepID=HEM3_BURM7 Length = 329 Score = 323 bits (828), Expect = 6e-87, Method: Composition-based stats. Identities = 162/315 (51%), Positives = 208/315 (66%), Gaps = 3/315 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 L L IA+R+S LA+WQA +V+D L +P V+++ M TRGD ILD L+KVGGKGL Sbjct: 10 LPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGL 69 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKELE AL + RAD+AVHS+KDVP+ P+G L + REDPRDAFVSN+Y SLDALPA Sbjct: 70 FVKELESALADGRADLAVHSLKDVPMALPEGFALAAVMSREDPRDAFVSNDYASLDALPA 129 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G++VGTSSLRR+ L R P L +R LRGN+ TRL+KLD G+Y AIILA AGLKRLGL + Sbjct: 130 GAVVGTSSLRREAMLRARHPRLDVRPLRGNLDTRLAKLDRGDYAAIILAAAGLKRLGLAA 189 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 RIRA L + SLPA GQGA+GIE + LA L+ H +AL V AERA++ L G Sbjct: 190 RIRALLDVDDSLPAAGQGALGIEIAARRADVAAWLAPLHDHASALAVEAERAVSRALGGS 249 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQI---IRGERRGAPQDAEQMGISLAEELLNNG 298 C+VP+ ++A GE+ L V DG+++ R DA +G +++ L G Sbjct: 250 CEVPLAAHAVWRGGELHLTGSVSTTDGARVLAAHAHARAATAADALALGRRVSDALERQG 309 Query: 299 AREILAEVYNGDAPA 313 AR I+ + A A Sbjct: 310 ARAIVDALVAASAQA 324 >UniRef50_D2NS36 Porphobilinogen deaminase n=2 Tax=Micrococcaceae RepID=D2NS36_9MICC Length = 454 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 134/372 (36%), Positives = 186/372 (50%), Gaps = 71/372 (19%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPG------------LVVELVPMVTRGDVI 48 M + + TR S LAL Q+ + + + + + L + T GD + Sbjct: 78 MSHHEYILGTRGSALALTQSRIAAETVTSLYTEHQAHHGAADAEVVDFTLRTVKTEGD-V 136 Query: 49 LDTPLAKVGGKGLFVKELEVALLENR-------ADIAVHSMKDVPVEFPQGLGLVTICER 101 L PLA +GG G+F L LL+ D+AVHS+KD+P GL + +R Sbjct: 137 LTGPLATLGGTGVFAAALRQRLLDGENASEENRVDMAVHSLKDLPSAPCPGLVIAATLKR 196 Query: 102 EDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-- 159 EDPRDA V+ + +LD LP GS VGT S RR QL RPDL I +RGNVGTR+ ++ Sbjct: 197 EDPRDALVARDGLTLDTLPEGSRVGTGSPRRAAQLRALRPDLEIVDIRGNVGTRIGRVKG 256 Query: 160 ----------------------------DNGEYDAIILAVAGLKRLGLESRIRAALPPEI 191 +G+ DA++LAV+GLKRLG E I L P Sbjct: 257 LEEHAGKQVVLRQNTETSERADHGVGTERSGDCDAVVLAVSGLKRLGKEELITEYLDPTR 316 Query: 192 SLPAVGQGAVGIECRLD-----------DSRTRELLAAL-------NHHETALRVTAERA 233 LPA GQGA+ +E R D + AL NHHET L V+AERA Sbjct: 317 MLPAPGQGALALEVRESEFENPDPAVLADPEVARPVRALGRALLAANHHETRLAVSAERA 376 Query: 234 MNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---AEQMGISL 290 + RLE GC PIG+YA +++G++ L +V +PDG+ ++R A D AE++G+ + Sbjct: 377 LLRRLEAGCAAPIGAYAHVVEGDLVLSVVVASPDGTDMLRHTSATAELDVPGAERLGVRV 436 Query: 291 AEELLNNGAREI 302 AE+LL GA + Sbjct: 437 AEDLLQMGAAAL 448 >UniRef50_C1TM53 Porphobilinogen deaminase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TM53_9BACT Length = 454 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 124/289 (42%), Positives = 159/289 (55%), Gaps = 8/289 (2%) Query: 10 TRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVA 69 +R+S LA Q L GL VE+ M T GD D L+ GG G FVK LE A Sbjct: 160 SRKSALARAQTMEAARALAKK--GLPVEIKTMSTCGDEKQDCHLSAFGGNGAFVKCLEEA 217 Query: 70 LLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSS 129 ++E + D A+HS+KDVP P GL LV + R D VSN+ L+ LPAG++VGTSS Sbjct: 218 IMEGKGDGAIHSLKDVPSVLPDGLELVAVLPRASTSDVIVSNHKGGLEGLPAGAVVGTSS 277 Query: 130 LRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPP 189 LRR+ QLA RPDL +RGNV TRL+KL +G+ DAI+LA AGL RLG+ LP Sbjct: 278 LRRKAQLAITRPDLDYTLIRGNVNTRLAKLQSGDADAIVLAKAGLDRLGISPEGATTLP- 336 Query: 190 EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSY 249 LPA QG + +E R SR E A+NH T L AER + L+ GC VP + Sbjct: 337 --FLPAPCQGIIAVEARSG-SRLAEEFRAINHRPTWLMALAERELLESLQVGCHVPFAAL 393 Query: 250 AELIDGEIWLRALVGAPDGSQI-IRGERRG-APQDAEQMGISLAEELLN 296 +E + GE+ LRA + DG I G + DA +G +A + Sbjct: 394 SEWVGGELRLRAQTLSYDGRHIDFEGSLAVRSDDDARDLGRDVALSIKA 442 >UniRef50_UPI000174444E Hydroxymethylbilane synthase n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI000174444E Length = 318 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 119/307 (38%), Positives = 156/307 (50%), Gaps = 18/307 (5%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG----- 57 + LR+ TR S LAL QA V+ L A+HP L VE + T GD D ++ Sbjct: 6 TDTLRLGTRGSELALRQAEMVEAALHAAHPYLRVERKVIATTGDKRPDLRFSEFTEGDRL 65 Query: 58 GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD 117 KG+F KELE+AL DIAVHS+KDVP + + + R D +S +L Sbjct: 66 DKGIFTKELEIALASGEIDIAVHSLKDVPTVLDEKFFIAGVLPRAPIEDVLISREGYTLA 125 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG-EYDAIILAVAGLKR 176 LPAG+ VGTSS+RR QL P + +RGNV TR+ KL + DAI+LA AGL+R Sbjct: 126 TLPAGAKVGTSSVRRIRQLQWLNPGVECVEIRGNVPTRIRKLFAPSDLDAILLARAGLER 185 Query: 177 LGLES----------RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETAL 226 L L L E LPA GQGA+GIE R+DD+ T E L A+NH ET Sbjct: 186 LSLLDGEHVVVDGQPLHAVILDCEEFLPAAGQGAIGIEARVDDAHTLEFLKAINHEETYA 245 Query: 227 RVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPD--GSQIIRGERRGAPQDAE 284 RVTAER L+ GCQ PIG++ L +G + ++ V G + Sbjct: 246 RVTAEREFLHILKAGCQTPIGAHTFLENGVLQMKVRVFDETDPGRPPKEVTSTEPYHSPK 305 Query: 285 QMGISLA 291 + +A Sbjct: 306 GLAAEVA 312 >UniRef50_C2GGB5 Porphobilinogen deaminase n=2 Tax=Corynebacterium glucuronolyticum RepID=C2GGB5_9CORY Length = 290 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 121/299 (40%), Positives = 165/299 (55%), Gaps = 11/299 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR S LA QA +V+D L+ + G EL + T GD L +P+ K+G G+F + Sbjct: 2 TLRIGTRGSKLATTQAGHVRDALIRA--GYDAELTIITTPGDKNL-SPVQKIG-VGVFTQ 57 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L A+ + DIAVHS KD+P P+GL + RE P +A ++ + +LD LP G+ Sbjct: 58 ALREAMDRDEIDIAVHSCKDLPTGQPEGLATI-YPVRETPCEALIARDGLTLDQLPEGAK 116 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGT + RR QL RPDL IR LRGNV TR+ K+ +GE DA+ILA AGL R+G Sbjct: 117 VGTGAPRRISQLKALRPDLDIRPLRGNVDTRMGKVTSGELDAVILAHAGLTRIGRGDEAT 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 P +PA QG + +E R L ++ H T L AERA+ + L+ GC Sbjct: 177 QVFDPTYLMPAPAQGILAVESRTHVDAISTL---IDDHAT-LSAQAERAVLSTLQAGCTA 232 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 P+ +Y+ + EI L A A DGS+ I G D +G S+AE+L GA EI+ Sbjct: 233 PLAAYSTVSGDEITLTAGAFALDGSKQIVETATGT--DPVALGTSVAEKLRACGAEEII 289 >UniRef50_D1VCA1 Porphobilinogen deaminase n=1 Tax=Frankia sp. EuI1c RepID=D1VCA1_9ACTO Length = 380 Score = 321 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 124/344 (36%), Positives = 179/344 (52%), Gaps = 44/344 (12%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 L + LR+ TR+S LAL Q+ V D+L G+ V+LV +VT GD ++++G G+ Sbjct: 36 LPSRLRLGTRRSALALAQSGMVADELRTR-LGIEVDLVHVVTEGDRNR-AEISQLGSTGV 93 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 +V L ALL D+AVHS+KD+P P+G+ L I RED RD VS +L L Sbjct: 94 WVSALREALLSGEVDLAVHSLKDLPTAPPEGITLAAIPPREDVRDVLVSPTGRTLAQLGP 153 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ +GT + RR QL L + +RGNV TR+ K +GE DA++LA AGL RL Sbjct: 154 GARIGTGAPRRAAQLRALGLGLDVVPIRGNVDTRIKKAIDGEVDAVVLARAGLARLDRLD 213 Query: 182 RIRAALPPEISLPAVGQGAVGIECRL--------------DDSR---------------- 211 I L PE+ LPA GQGA+ IEC +D Sbjct: 214 AITELLEPEVMLPAPGQGALAIECVATTLAPLTLLTVGTPEDQGAVTGMSCPVAPGSGVE 273 Query: 212 --TRELLAA-LNHHETALRVTAERAMNTRLEGGCQVPIGSYAEL---------IDGEIWL 259 LL L+ +++ V AERA +E GC P+G+ A++ +GE+ L Sbjct: 274 IPLERLLRFVLDDAPSSVAVRAERAFLAAIEAGCTAPVGALAQVLPARGQAPASEGEVRL 333 Query: 260 RALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 RA+V + DG+ ++R E G+ D E +G LA++LL+ GA ++ Sbjct: 334 RAVVASLDGTTVLRRELGGSTADPEALGRRLADDLLSAGAHTLM 377 >UniRef50_A4WN24 Probable porphobilinogen deaminase n=3 Tax=Thermoproteaceae RepID=HEM3_PYRAR Length = 297 Score = 321 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 110/293 (37%), Positives = 157/293 (53%), Gaps = 6/293 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L +ATR S L++ Q + ++ A P + E+ + T GD + D PL ++G KG+F KE Sbjct: 3 LVVATRGSKLSMLQTEELLAQIKAVEPSIEFEIKIVKTTGDEVQDKPLYQIGVKGIFEKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 + +A+L AD+AVHS+KD+P E GL L +R P DA VS L+ LP G++V Sbjct: 63 VNLAVLRGEADVAVHSLKDLPSELSPGLVLAGFSKRAPPFDAVVSTAGYVLETLPRGALV 122 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL-GLESRIR 184 GTSS+RR + RPD+ + LRGNV TR++K+ G+YDA I+AVAG+ RL G I+ Sbjct: 123 GTSSVRRAEFVKAIRPDVRVEPLRGNVDTRINKILQGKYDAAIMAVAGIYRLYGASPPIK 182 Query: 185 -AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 A L PE+ P GQG V R DS +LL + + +L AER + GC Sbjct: 183 LAVLRPEVLPPPPGQGIVAAVVREADSWLIDLLKKASDPKASLEAIAEREFLKAVGAGCH 242 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 V IG A + + A + G + G D ++G AEE+ Sbjct: 243 VAIGGVAFARNDTVEFIAGYAS--GGRKYIVRVVG--DDPVEVGRRAAEEIRK 291 >UniRef50_Q2NEP4 HemC n=4 Tax=Methanobacteriaceae RepID=Q2NEP4_METST Length = 290 Score = 320 bits (822), Expect = 3e-86, Method: Composition-based stats. Identities = 91/292 (31%), Positives = 149/292 (51%), Gaps = 4/292 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 + + TR S LA Q V L G +E + T GD I ++ L + KG+F KE Sbjct: 1 MIVGTRGSKLATTQTKTVVKALEEIT-GEEIETKIIKTTGDKIKNSQLYNIDAKGIFTKE 59 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L+ AL++ D AVHS KD+P E L + I +RE + +SN S D LP + + Sbjct: 60 LDTALIDGSIDFAVHSFKDLPSELNDQLTITAIPQREAINEVLISN--YSWDELPENATL 117 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR+ + + +RGN+ TR+ K++ GEYDA I+A+AG+ RLGL+ I+ Sbjct: 118 GTSSVRREAFCKLHGKKIQTKPIRGNIDTRIRKVEEGEYDATIMALAGINRLGLQEHIKE 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 + P GQGA+ + DS ++++ LNH ++ + E+A+ + GCQ P Sbjct: 178 VFDEQYITPPAGQGALAVMTHK-DSEYNDVISKLNHEDSRIEAMTEKAILETIGVGCQWP 236 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 IG +++ I + + +P+G + + +A + +L + Sbjct: 237 IGIVSKVDGNNINIHCKLLSPEGKLLADVNKTTDKNNAINTAKVIGTKLRED 288 >UniRef50_Q9F7M2 Predicted porphobilinogen deaminase n=2 Tax=Bacteria RepID=Q9F7M2_PRB01 Length = 303 Score = 320 bits (821), Expect = 4e-86, Method: Composition-based stats. Identities = 111/306 (36%), Positives = 173/306 (56%), Gaps = 4/306 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +RIATRQS LA++QA +V D+L+A + VELVPM + GD D PL ++GGKGLF+ Sbjct: 2 KIRIATRQSELAMYQAKFVADELLAKINNIKVELVPMTSEGDQ-TDKPLHEIGGKGLFIS 60 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 LE +L + ADIAVHS+KDVP + ++++ RE P D +S + S S Sbjct: 61 TLESSLEADEADIAVHSLKDVPAKLDPKFKIISVFSRESPEDLLLSKDGKSFSEFARNST 120 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTS RR+ Q+ RPD+ +RGN+ TR+ KL++G +D +++A A +KRLGL+ Sbjct: 121 IGTSGPRRKAQINNLRPDIKTIPVRGNIATRIKKLNDGLFDGLVVAKAAIKRLGLKQNSY 180 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 E LP+ QG + IEC D ELL + + + +AER+ +EG C Sbjct: 181 E-FSIEEMLPSASQGYIAIECLSDKKDIIELLENIGDPKELILASAERSFVAAMEGTCLS 239 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 PI E +G+I + + + +G++ I E+ + QD + A+E + GA+ ++ Sbjct: 240 PIAILCEDKNGQIKISGKILSYEGNEKIYKEKISSFQDIAIDIMLFADEFILEGAKSLI- 298 Query: 305 EVYNGD 310 + N + Sbjct: 299 -LKNDN 303 >UniRef50_C6R3Y0 Hydroxymethylbilane synthase n=1 Tax=Rothia mucilaginosa ATCC 25296 RepID=C6R3Y0_9MICC Length = 377 Score = 319 bits (819), Expect = 7e-86, Method: Composition-based stats. Identities = 134/372 (36%), Positives = 186/372 (50%), Gaps = 71/372 (19%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLV------------VELVPMVTRGDVI 48 M + + TR S LAL Q+ + + + + EL + T GD + Sbjct: 1 MSHHEYTLGTRGSALALTQSRIAAETVTSLYTEHQAHHGAENPEAVSFELRTVKTEGD-V 59 Query: 49 LDTPLAKVGGKGLFVKELEVALLENR-------ADIAVHSMKDVPVEFPQGLGLVTICER 101 L PLA +GG G+F L LL+ D+AVHS+KD+P GL + +R Sbjct: 60 LTGPLATLGGTGVFAAALRQRLLDGENASEENRVDMAVHSLKDLPSAPCPGLVVAATLKR 119 Query: 102 EDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-- 159 EDPRDA V+ + ++D LP GS VGT S RR QL RPDL I +RGNVGTR+ ++ Sbjct: 120 EDPRDALVARDGLTVDTLPEGSRVGTGSPRRAAQLRALRPDLEIVDVRGNVGTRIGRVKG 179 Query: 160 ----------------------------DNGEYDAIILAVAGLKRLGLESRIRAALPPEI 191 +G+ DA++LAV+GLKRLG E I L P Sbjct: 180 LEEHAGKQVVLRQNAETSERADHGVGTERSGDCDAVVLAVSGLKRLGKEELITEYLDPTR 239 Query: 192 SLPAVGQGAVGIECRLD-----------DSRTRELLAAL-------NHHETALRVTAERA 233 LPA GQGA+ +E R D + AL NHHET L V+AERA Sbjct: 240 MLPAPGQGALALEVRESEFENPDSAVLADPEVARPVRALGRALLAANHHETRLAVSAERA 299 Query: 234 MNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---AEQMGISL 290 + RLE GC PIG+YA +++G++ L +V +PDG+ ++R A D AE++G+ + Sbjct: 300 LLRRLEAGCAAPIGAYAHVVEGDLVLNVVVASPDGTDMLRHTSATAELDVPGAERLGVRV 359 Query: 291 AEELLNNGAREI 302 AE+LL GA + Sbjct: 360 AEDLLQMGAAAL 371 >UniRef50_A0QLI0 Porphobilinogen deaminase n=69 Tax=Actinomycetales RepID=HEM3_MYCA1 Length = 315 Score = 318 bits (816), Expect = 2e-85, Method: Composition-based stats. Identities = 133/311 (42%), Positives = 175/311 (56%), Gaps = 13/311 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LA QA V+D L+A G ELV + T GD P+ +G G+F Sbjct: 2 IRIGTRGSLLATTQAGGVRDALIAR--GHPAELVTITTAGDR-SSGPIESLG-VGVFTTA 57 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L A+ E R D AVHS KD+P + I R DPRDA V+ + L LP GS+V Sbjct: 58 LREAIEEGRVDAAVHSHKDLPTADDPRFAVAAIPARNDPRDAVVARDGLVLGELPPGSLV 117 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS RR QL L IR LRGN+ TRL+++ +G+ DAI++A AGL RLG + Sbjct: 118 GTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLGDVTE 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L P LPA QGA+ +ECR DSR +LA L+ +T VTAERA+ LE GC P Sbjct: 178 TLEPVQMLPAPAQGALAVECRAGDSRLAAVLAELDDADTRASVTAERALLAELEAGCSAP 237 Query: 246 IGSYAELID---------GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 +G+ AE+++ E+ LR V A DGS +IR G P A ++G+S+A EL Sbjct: 238 VGAIAEVVESIDEDGRIFEELSLRGCVAALDGSDVIRASGIGTPGRARELGLSVAAELFE 297 Query: 297 NGAREILAEVY 307 GARE+++ Sbjct: 298 LGARELMSGAR 308 >UniRef50_Q8D2W2 HemC protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis RepID=Q8D2W2_WIGBR Length = 291 Score = 318 bits (816), Expect = 2e-85, Method: Composition-based stats. Identities = 132/289 (45%), Positives = 193/289 (66%), Gaps = 1/289 (0%) Query: 20 AHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAV 79 + K KL+ HP L ++LVP++T GD+I KGLF+KELE +LL+ ++DIAV Sbjct: 3 SKLCKKKLLHYHPKLNIKLVPILTTGDLINKIRNNITNEKGLFIKELEKSLLKYQSDIAV 62 Query: 80 HSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAER 139 HSMKD F LGL IC+R+DPRDA VSN Y+++ +LP + VGTSSLRR+CQL Sbjct: 63 HSMKDFSSSFLDSLGLAAICKRDDPRDAIVSNYYNNIISLPNNAKVGTSSLRRKCQLLSI 122 Query: 140 RPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQG 199 RPDL I +GN+ +RL KL+ G +DA+ILA A LKRL + ++ + P LPA+GQG Sbjct: 123 RPDLKIFPCKGNIHSRLKKLNQGVFDALILATAALKRLKINEQMYTPIDPSYLLPAMGQG 182 Query: 200 AVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID-GEIW 258 ++ I+CRL D++ +++ +N+ +TAL + +E+ + + L GC+VPIGSYA++ + IW Sbjct: 183 SIAIQCRLYDNKIIDIVRNINNKKTALCINSEKIVVSMLGTGCRVPIGSYAKIENKNTIW 242 Query: 259 LRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVY 307 +RALVG+ DGS IIR E + +AE++ + L+N GA+ IL + Sbjct: 243 IRALVGSIDGSNIIRSEGKSCVSNAEKLSKKQVKNLINLGAKNILKKFK 291 >UniRef50_C0BZ93 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM 15053 RepID=C0BZ93_9CLOT Length = 298 Score = 318 bits (815), Expect = 2e-85, Method: Composition-based stats. Identities = 118/296 (39%), Positives = 161/296 (54%), Gaps = 5/296 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + +++RI +R+S LA+ QA VK + + P + E+V M T GD ILD L GGKGL Sbjct: 1 MQSIIRIGSRESRLAVKQAEIVKQAVERNCPDIKAEIVTMKTEGDKILDRRLELAGGKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKELE ALL+ R DI VHS+KDVP+E P+ L +V EREDPRD + + ++P Sbjct: 61 FVKELEKALLDGRIDICVHSLKDVPMEVPEDLPVVAFGEREDPRDVLIYKPGRT--SIPE 118 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G ++GTSS RR+ QL P RS+RGNV TRL KL +D +LA AGLKRL +E Sbjct: 119 GGVIGTSSRRRELQLKRLYPSCTFRSIRGNVQTRLRKLSEEGFDGTVLAAAGLKRLHMEE 178 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + +PAVGQG + ++ R L + ++ AER L GG Sbjct: 179 VAGRVFSVDEIIPAVGQGILAVQGRKGRDY--SWLTSFACGKSRAEAEAEREFAAALGGG 236 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 C P+ ++A+ E+ L L G R G A Q+G +LAEE+ Sbjct: 237 CTSPVAAHAQAQGAELKLTGLYYC-GGDIYRTRTRTGETDRARQLGAALAEEMRRE 291 >UniRef50_Q57989 Probable porphobilinogen deaminase n=11 Tax=Methanococcales RepID=HEM3_METJA Length = 292 Score = 317 bits (812), Expect = 4e-85, Method: Composition-based stats. Identities = 106/296 (35%), Positives = 156/296 (52%), Gaps = 10/296 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LAL+QA+ V + L G VE+ + T GD +LD L+ +G G+F KE Sbjct: 2 IRIGTRGSKLALYQANKVAELLKNL--GYKVEIKIIKTTGDRVLDKKLSDIG-IGVFTKE 58 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L++A+L N DIAVHS+KD+P + + L + + ER+ D + N + + ++ Sbjct: 59 LDLAMLNNEIDIAVHSLKDIPTIWNENLMVGAVLERDSYHDLLIWNKDIDFNE-DSKIVI 117 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR+ L P+ LRGNV TRL KL G YDAI+L+ AG+ RLG+ Sbjct: 118 GTSSMRRRAFLKFIYPNAKFELLRGNVDTRLRKLKEGLYDAIVLSEAGIIRLGVSLEDFN 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 +I LPA QG + + C+ DD + +L +NH T L ER GGC VP Sbjct: 178 YKRLDI-LPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSVP 236 Query: 246 IGSYAELIDGE--IWLRALVGAPDGSQIIRGERRGAPQD---AEQMGISLAEELLN 296 G+ A + + L+A V D + GE + + A ++G + +L N Sbjct: 237 FGALAVYDEKNELLKLKAAVVTNDELKNASGEVKCKIDEIDKAVELGKKIGLKLKN 292 >UniRef50_A1DGB8 Porphobilinogen deaminase n=1 Tax=Neosartorya fischeri NRRL 181 RepID=A1DGB8_NEOFI Length = 363 Score = 316 bits (811), Expect = 5e-85, Method: Composition-based stats. Identities = 120/342 (35%), Positives = 162/342 (47%), Gaps = 39/342 (11%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKL-MASHPGLVVELVPMVTRGDVILDTPLAKVG---- 57 + V+ R+S LAL Q +V KL P ++ GD P A + Sbjct: 20 EEVVIFGCRKSELALVQTRWVTSKLGQTLDPSPTFQIATGSAVGDADKQAPFAVLSKLTG 79 Query: 58 ----GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN-- 111 GK L+ ELE+ L+ + VHS+KD+P P L + ERED DA Sbjct: 80 GSDIGKSLWTNELELDLVAGKVHCLVHSLKDMPTTLPPHCLLGAVPEREDCSDAVCMRSD 139 Query: 112 -NYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAII 168 + S+D LP GSIVGTSS RR+ + P L + RGNV TRL+KLD + I+ Sbjct: 140 LKFTSIDQLPPGSIVGTSSSRRKALVRRNWPHLEVVECRGNVDTRLAKLDAPSSRFSCIL 199 Query: 169 LAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRV 228 LA AGL RLGL RI L I AVGQGA+G+E D EL+ ++H + R Sbjct: 200 LATAGLLRLGLGHRITHRLDDSIFPYAVGQGALGLEVSTDRPDILELVRHVDHKPSRWRG 259 Query: 229 TAERAMNTRLEGGCQVPIGSYAELI----------------------DGEIWLRALVGAP 266 AERAM L+GGC PIG + L G + LRA+V Sbjct: 260 IAERAMLRSLQGGCSSPIGVQSSLEPLGKEENGSTEDDSQRGRDSSSGGNLSLRAMVLHI 319 Query: 267 DGSQIIRGERRGAP---QDAEQMGISLAEELLNNGAREILAE 305 +G+ I E ++AE +G+S+A LL GAR ++ + Sbjct: 320 EGTSEIVAEDMATVRCDEEAELLGVSVANMLLAKGARGLMPK 361 >UniRef50_UPI0001BC2D4C glutamyl-tRNA reductase n=1 Tax=Brevibacterium linens BL2 RepID=UPI0001BC2D4C Length = 825 Score = 316 bits (810), Expect = 8e-85, Method: Composition-based stats. Identities = 115/333 (34%), Positives = 169/333 (50%), Gaps = 30/333 (9%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 +R+ TR+S LA Q+ + +L A G VE+V +VT GDV + +PL GG G+ Sbjct: 475 SGRTIRLGTRRSKLARSQSTAIAHQLAAL-TGWRVEIVEVVTEGDVNM-SPLTGFGGTGV 532 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FV + AL + + DIAVHS+KD+P G+ + I R DP D + + S LPA Sbjct: 533 FVSAVRQALHQGKIDIAVHSLKDLPTTPEAGIQMAAIPPRVDPADVLIGRDGLSFAELPA 592 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 GS+VGT S RR QL RPD+ +R +RGNV TR++ + +G DA++LA AG++R+G + Sbjct: 593 GSVVGTGSPRRAVQLRAARPDIEVRGVRGNVDTRIAHVRDGRLDAVVLAAAGVRRIGRLA 652 Query: 182 RIRAALPPEISLPAVGQGAVGIECR-------------LDDSRTRELLAALNHHETALRV 228 +L + LPA GQGA+ +E R D+ R L L+ T L V Sbjct: 653 EATDSLDFDTMLPAPGQGALAVETRGADSPFALDNEVMEADAEVRTQLKRLHDETTDLAV 712 Query: 229 TAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER------------ 276 T ERA+ +R E GC PIG+ A + + + A++ DG + Sbjct: 713 TCERAILSRAEAGCSAPIGALATIQGSDFVVDAVMADDDGKLARTRQVAPLPTTPDVDLD 772 Query: 277 RGAPQDAEQMGISLAE---ELLNNGAREILAEV 306 G+ G LA EL A ++L ++ Sbjct: 773 SGSANQLSITGKELARLADELGTAAAEDLLGQL 805 >UniRef50_D1C4S0 Porphobilinogen deaminase n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C4S0_SPHTD Length = 311 Score = 315 bits (809), Expect = 9e-85, Method: Composition-based stats. Identities = 124/299 (41%), Positives = 161/299 (53%), Gaps = 2/299 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +R+ TR S LA Q V L A P L + + T GD TPL +GG+G+F +E Sbjct: 11 VRLGTRGSALAREQTRRVMAALAALRPDLELIETIVSTAGDRDKRTPLTVIGGQGVFARE 70 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L+ ALL D+AVHS KD+P E GL + RED RD VS + SL LP G+ V Sbjct: 71 LQTALLAGTVDVAVHSAKDLPTEPVPGLVIGAFFSREDARDVLVSRDGRSLADLPPGARV 130 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS RR L RPDL LRGN+ TRL K+ GE DA ILA AGL R+G + I Sbjct: 131 GTSSRRRLVALRRLRPDLEAVDLRGNLDTRLRKVREGEVDAAILAAAGLLRMGWQEHITE 190 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L + +PA GQGA+ IECR DD E+LAALN AL ER+ L GGC+ P Sbjct: 191 FLSLDDFVPAPGQGALAIECRADDPAVNEMLAALNDPAAALAARTERSFLRALGGGCRSP 250 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN--NGAREI 302 IG++A + + LR ++G +++ +AE +LA E+ GA + Sbjct: 251 IGAHATVSGDTVTLRVMLGDEAMTRVRLSTWTLPAAEAETRAGALAVEVQRSLAGADPL 309 >UniRef50_O26960 Probable porphobilinogen deaminase n=1 Tax=Methanothermobacter thermautotrophicus str. Delta H RepID=HEM3_METTH Length = 289 Score = 315 bits (808), Expect = 1e-84, Method: Composition-based stats. Identities = 102/286 (35%), Positives = 153/286 (53%), Gaps = 4/286 (1%) Query: 9 ATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEV 68 TR S LAL Q ++V + L + + + +GD I D+ L + +GLF +EL++ Sbjct: 4 GTRGSRLALVQTNHVIEMLSEVCKEKIEKKIIKT-KGDRIRDSQLYSMDSRGLFTRELDM 62 Query: 69 ALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTS 128 A+L D+AVHS+KDVP + L + + RE P + VS + LP GS +GTS Sbjct: 63 AVLNEEVDLAVHSLKDVPSDLDPDLAIAAVPPRESPAEVLVSR--LDWEDLPQGSKLGTS 120 Query: 129 SLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALP 188 SLRR+ + + + LRGN+ TR+ K+ +GE A I+A AGLKRLGLE I+ P Sbjct: 121 SLRREAFCNHHQKNFKMEPLRGNIDTRIRKVMDGEVHATIMAEAGLKRLGLEEHIKRRFP 180 Query: 189 PEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGS 248 E PA GQGA+ + R DS + + HH + VTAE+ + L GCQ P+G Sbjct: 181 VEYFTPAAGQGALAVITRA-DSELISSIGRITHHPSLQEVTAEKTLLRELGAGCQCPLGV 239 Query: 249 YAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 ++ L A++ +G + + RG +AE +G A+E+ Sbjct: 240 IGRATGNQLTLYAVLLTREGEMLRKVTVRGPLAEAEDIGKKAAKEM 285 >UniRef50_Q1EPC8 Porphobilinogen deaminase, chloroplast (Hydroxymethylbilane synthase) (Pre-uroporphyrinogen synthase), putative n=1 Tax=Musa acuminata RepID=Q1EPC8_MUSAC Length = 328 Score = 315 bits (808), Expect = 1e-84, Method: Composition-based stats. Identities = 126/296 (42%), Positives = 163/296 (55%), Gaps = 34/296 (11%) Query: 11 RQSPLALWQAHYVKDKLMASHPGLV----VELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66 R S LAL QA +DKL A+H L VE++ + T GD+ILD PLA +GGKGLF KE+ Sbjct: 54 RDSDLALAQARETRDKLKAAHSELAEEGAVEIIIIKTTGDMILDKPLADIGGKGLFTKEI 113 Query: 67 EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126 + ALL+ R DIAVHSMKDVP P+G L Sbjct: 114 DDALLQGRIDIAVHSMKDVPTYLPEGTILPCNLP-------------------------- 147 Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAA 186 +SLRRQ Q+ R P L + +LRGNV TRL+KL NG+ A +LA+AGLKRL + + + Sbjct: 148 -ASLRRQSQILCRYPSLKVVNLRGNVQTRLTKLKNGDVHATLLALAGLKRLNMVENVTSI 206 Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246 L E LPAV QGA+GI CR +D++ E L++LNH +T V ER T L+G C+ PI Sbjct: 207 LSMEEMLPAVAQGAIGIACRSNDNKMMEYLSSLNHEDTRSAVACEREFLTVLDGNCRTPI 266 Query: 247 GSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAP--QDAEQMGISLAEELLNNGA 299 +YA DG R L+ +PDGS++ R G D +MG EL Sbjct: 267 AAYAHRDKDGSCSFRGLLASPDGSKVYETTRIGPYSFDDMVEMGKDAGHELKAKAG 322 >UniRef50_C5CB88 Porphobilinogen deaminase n=5 Tax=Actinomycetales RepID=HEM3_MICLC Length = 377 Score = 314 bits (806), Expect = 2e-84, Method: Composition-based stats. Identities = 129/356 (36%), Positives = 179/356 (50%), Gaps = 61/356 (17%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 + LRI TR S LA Q +V + L A GL ELV + T GD + LA +GG G+F Sbjct: 2 SPLRIGTRGSALATTQTSHVAEALTARS-GLAHELVVIRTEGD-VTTGSLASLGGTGVFA 59 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 L A+L+ D AVHS+KD+P P+ L + + R D RDA + + +L LP G+ Sbjct: 60 SALRAAVLDGVVDAAVHSLKDLPAAQPETLEIAAVPARADLRDALCARDGLTLATLPEGA 119 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL----------------DNGEYDAI 167 VGT S RR QL RPDL + +RGNV TRL+++ G+ DA+ Sbjct: 120 RVGTGSPRRVAQLKALRPDLELVDIRGNVQTRLARVPGLEQHDDHAPAAVGSPRGDLDAV 179 Query: 168 ILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDS---------------RT 212 ILA AGL RLGL+ I + PE+ +PA GQGA+ +E R +D R Sbjct: 180 ILACAGLDRLGLDHVITERIDPEVMVPAPGQGALAMEIRAEDESFLGRALLDPEAPVGRL 239 Query: 213 RELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDG-----EIWLRALVGAPD 267 L ++ +T + VTAERA+ RLE GC PIG+ A + DG I + A+V A D Sbjct: 240 HAALELVDDRDTHVAVTAERALLRRLEAGCAAPIGAVARVGDGEAGAPRIEMTAMVAALD 299 Query: 268 GSQIIR-----------GERRGAPQ------------DAEQMGISLAEELLNNGAR 300 GS+++R + G P AE +G+ +AE+ + GA Sbjct: 300 GSRVLRRTSSVQLDPVPADVVGDPAAADEWLEDTLFVAAEALGVHVAEQFVAEGAD 355 >UniRef50_B6JII8 Porphobilinogen deaminase n=11 Tax=Bradyrhizobiaceae RepID=B6JII8_OLICO Length = 338 Score = 313 bits (802), Expect = 6e-84, Method: Composition-based stats. Identities = 111/323 (34%), Positives = 159/323 (49%), Gaps = 18/323 (5%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG-L 61 D +RI TR+S +AL Q + +L A+ P L VE+V T GD L +GGKG Sbjct: 11 DKAMRIGTRKSVMALAQTSEIARQLTAADPALDVEIVKFETTGDQDQTGKLLDLGGKGGA 70 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFP-QGLGLVTICEREDPRDAFVSNNYDSLDAL- 119 FV ++ A+ E R + A+HS+KD+P GL + R+ P DA V + +L L Sbjct: 71 FVAQIRDAVREGRLEAAMHSLKDMPGNEDTPGLVIGATLTRDPPTDALVVRHGVTLADLR 130 Query: 120 ---PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE------------Y 164 G +GT+++RR + P+ I RG TR+ KLDNGE Sbjct: 131 RTGGKGFKIGTNAVRRAAYVRRLFPECEIIHFRGAADTRIRKLDNGEKQRLPEGGEVGPA 190 Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224 DA+++A AGL+R+G RI P+ LPAVGQG V +EC D T LA ++ + Sbjct: 191 DALVMAQAGLERVGCADRIAHCFSPDEILPAVGQGIVAVECAASDWCTLARLAQIDDPVS 250 Query: 225 ALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAE 284 AER + L G C PI YA + ++ L+A V I RRG Sbjct: 251 RCCAAAEREVLWVLNGHCNSPIAGYAIVEGDDVLLKAAVLDEANDHFIEVTRRGPASRPR 310 Query: 285 QMGISLAEELLNNGAREILAEVY 307 ++G ++A ELL GA +++A Sbjct: 311 ELGRAVAFELLAKGAADVIARTR 333 >UniRef50_C9RPT6 Porphobilinogen deaminase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RPT6_FIBSS Length = 351 Score = 312 bits (801), Expect = 9e-84, Method: Composition-based stats. Identities = 128/346 (36%), Positives = 170/346 (49%), Gaps = 57/346 (16%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHP-------------GLVVELVPMVTRGDV 47 M D LRIATR+S LAL Q D ++A++ L ELV M T GD Sbjct: 1 MSDLKLRIATRKSALALAQTTMAADAIVAANSVIGNAADSNNARDSLTYELVSMTTEGDR 60 Query: 48 ILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDA 107 LD LA GGKG+F+KELE+ALLE RADIA+HS+KD+P E L + +REDPRDA Sbjct: 61 RLDKSLASFGGKGVFIKELEIALLEGRADIAIHSLKDMPAEVLPQFKLAAVLKREDPRDA 120 Query: 108 FVSNNYD---SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY 164 F+S LPAG+ VGT S+RR QL RPDL +RGN+ TR+ KL E Sbjct: 121 FLSRGGSAGIRFMDLPAGARVGTGSIRRVVQLKALRPDLEYVPIRGNIQTRIGKLA--EL 178 Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLD----------DSRTRE 214 D ++LA AGLKR+GL ++ E LPA GQG + IE D + + Sbjct: 179 DGVVLAAAGLKRMGLADQVTEYFSTEQMLPASGQGILAIETLNDATVQESRVTGRADLAQ 238 Query: 215 LLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDG------------------- 255 +LA +N T +AE A L GCQ P+ S+AE + Sbjct: 239 ILARVNDVATYCIASAEMAYLKALNAGCQFPVASFAEFVCEDGIENRGTCGALEENANRI 298 Query: 256 --EIWLRALVGAPDGSQIIRGERRGAPQ--------DAEQMGISLA 291 + +R + +++R E G ++ +GI LA Sbjct: 299 AQTLKIRGIYWDEKSEKLLRAEVAGNVDLNSEDCVQQSKNLGIELA 344 >UniRef50_Q6AHF1 Porphobilinogen deaminase n=5 Tax=Actinobacteria (class) RepID=HEM3_LEIXX Length = 329 Score = 310 bits (796), Expect = 3e-83, Method: Composition-based stats. Identities = 115/310 (37%), Positives = 158/310 (50%), Gaps = 15/310 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LR+ TR SPLA+ Q V + + G +ELV + T GD + L+++GG G+F Sbjct: 15 LRVGTRGSPLAVAQTQAVSAAVARA-TGFDIELVTVTTHGDTSRE-SLSELGGTGVFATA 72 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L AL D+ VHS+KD+P GL L + +R D RD + + LP G+ V Sbjct: 73 LRDALRNGECDLVVHSLKDLPTAPAPGLVLGAVPKRADARDTLCARDGLRFGELPEGASV 132 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT S RR QL +RP L I +RGNV TRLS++ G+ DA++LA AGL RLG Sbjct: 133 GTGSPRRAAQLRAQRPGLDIVDIRGNVDTRLSRVSAGDLDAVVLAAAGLGRLGRLDAATD 192 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSR----TRELLAALNHHETALRVTAERAMNTRLEGG 241 A GQGA+ +E R D R LAA++H T TAERA+ LE G Sbjct: 193 FFSLSTMPTAPGQGALALEVREGDERGRGPIARALAAVDHATTCAATTAERAVLAGLEAG 252 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---------AEQMGISLAE 292 C P+G+ A + DG ++L A V PDG+ + P A +G + Sbjct: 253 CAAPVGATAMIDDGLLFLTATVYRPDGAAQLTASHAATPDSFGAAHLDEAARDVGERVVA 312 Query: 293 ELLNNGAREI 302 ELL +GA ++ Sbjct: 313 ELLASGAADL 322 >UniRef50_A3VPD5 Porphobilinogen deaminase n=1 Tax=Parvularcula bermudensis HTCC2503 RepID=A3VPD5_9PROT Length = 324 Score = 308 bits (791), Expect = 1e-82, Method: Composition-based stats. Identities = 135/286 (47%), Positives = 178/286 (62%), Gaps = 6/286 (2%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMAS------HPGLVVELVPMVTRGDVILDTPLA 54 M LRIA+R+SPLA+ QA +V+D+L + VT GD +L+ LA Sbjct: 1 MSFKPLRIASRRSPLAVAQALWVRDRLAEALGIDEVDRDAAFPHETFVTTGDRMLNPTLA 60 Query: 55 KVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD 114 +GGKGLF KE+E+ALL+ +ADIAVHSMKD+P + P GL L + REDPRDAFV+ + Sbjct: 61 DIGGKGLFTKEIEIALLDGQADIAVHSMKDMPAQMPPGLVLAAVPVREDPRDAFVTLDGR 120 Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174 LD +PAG+ +GTSS RR+ QLA RPDL + +RGNVGTRL KL GE + LA AGL Sbjct: 121 PLDQMPAGARIGTSSTRRRAQLARLRPDLALVPMRGNVGTRLQKLAAGEAEGTFLAEAGL 180 Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234 +RLG+ R AL P LPA+GQGA+ ++ R D T A +N+ TAL AERA+ Sbjct: 181 RRLGMTDVKREALSPARMLPALGQGALCVQARSGDHETLSACAHINNRPTALAAAAERAL 240 Query: 235 NTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAP 280 + L+G C+ PIG A + L + PDG +++RGER A Sbjct: 241 ISGLDGSCKTPIGGLARQTGDSLILEGQILTPDGRRVLRGERTVAI 286 >UniRef50_A8PWJ5 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8PWJ5_MALGO Length = 530 Score = 308 bits (791), Expect = 1e-82, Method: Composition-based stats. Identities = 131/394 (33%), Positives = 187/394 (47%), Gaps = 92/394 (23%) Query: 5 VLRIATRQSPLALWQAHYV------------------------------KDKLMASHPG- 33 L +++R+S LA+ QA V + L P Sbjct: 89 TLVLSSRKSELAVRQATQVQMLLDTRYGRASPVFAPGADQWPSTEVANIRAFLRTFSPDQ 148 Query: 34 -----LVVELVPMVTRGDVILDTPLAKVGGKG--LFVKELEVALLENRADIAVHSMKDVP 86 + + M T GD L +PL +GG+G ++ KELEVAL+ D VHS+KDVP Sbjct: 149 KDVRPVDFPVRTMATLGDQNLKSPLYVIGGEGRAIWTKELEVALMAGGVDAIVHSLKDVP 208 Query: 87 VEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALPAGSIVGTSSLRRQCQLAERRPDL 143 P G+ L I EREDPRDA V Y SL +P GS++GTSS+RR L P L Sbjct: 209 TTMPDGVELAAILEREDPRDALVVKENLPYKSLQEMPQGSVIGTSSVRRVSLLRRAYPHL 268 Query: 144 IIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAV 201 + +RGN+ TRL+KLD +G Y A++LA AGLKR+ LE RI A + + L AVGQG++ Sbjct: 269 MFSDVRGNINTRLAKLDAADGPYTALVLAAAGLKRMDLEHRITAYVSEPVMLHAVGQGSL 328 Query: 202 GIECR-------LDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELI- 253 IE R D R R ++ ++++ R AERA+ R+EGGC +P+G Sbjct: 329 AIEVRTPRGESAERDERIRRMIRSISNWRATWRCVAERALMHRMEGGCSIPLGVSTRFED 388 Query: 254 -------------------------------------DGEIWLRALVGAPDGSQIIRGER 276 + + A++ + DG+++ + Sbjct: 389 HADIEGLLNERNETPSEMASAGISRPDIRIAHEPPPQGSFLTMAAVIVSLDGTRMCKHSH 448 Query: 277 R---GAPQDAEQMGISLAEELL-NNGAREILAEV 306 + +DAEQ+GI +AEEL + AR ILAEV Sbjct: 449 TQLCRSEKDAEQLGILVAEELEHHQNARAILAEV 482 >UniRef50_C5EV71 Pyruvate ferredoxin/flavodoxin oxidoreductase n=3 Tax=Clostridiales RepID=C5EV71_9FIRM Length = 301 Score = 308 bits (789), Expect = 2e-82, Method: Composition-based stats. Identities = 119/305 (39%), Positives = 165/305 (54%), Gaps = 15/305 (4%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + N++RI TR+S LAL Q H + D L + P + VELV T GD ILD PL + GGKG+ Sbjct: 1 MSNIIRIGTRKSALALIQTHLIADGLKRAWPDIEVELVTKETLGDKILDKPLQEFGGKGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FV E E A+ E D+AVHS KD+P+E +GL + + R DPRD V+ D Sbjct: 61 FVSEFEQAMKEGAIDLAVHSAKDLPMELGEGLVIAAVSGRGDPRDVLVTMKGSPKDR--E 118 Query: 122 GSIVGTSSLRRQCQLAERR-------PDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174 ++GTSS RRQ + E R L +LRGNV TRL KL+ G YD IILA AGL Sbjct: 119 HIVIGTSSPRRQLEAVEYRGQLWPGAASLTCATLRGNVHTRLRKLEEGLYDGIILAAAGL 178 Query: 175 KRLGLESRIRA---ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231 +RL L L P + +PA GQG + +E R R L A++ E L +T E Sbjct: 179 ERLDLLGNPSYDFKYLDPTVFIPAGGQGIMAVEAREGSDAAR-LCQAIDSREGRLCLTLE 237 Query: 232 RAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDG-SQIIRGERRGAPQDAEQMGISL 290 R + L+ GC PIG Y+ ++DG++ + + PD ++ I E ++ E + + Sbjct: 238 RMVLKLLDAGCHEPIGIYSNIMDGKMEVWG-ISRPDRVTRRISLEGAVTEKELEALALQA 296 Query: 291 AEELL 295 L+ Sbjct: 297 GRGLM 301 >UniRef50_B2ULP1 Porphobilinogen deaminase n=1 Tax=Akkermansia muciniphila ATCC BAA-835 RepID=B2ULP1_AKKM8 Length = 325 Score = 306 bits (784), Expect = 8e-82, Method: Composition-based stats. Identities = 121/317 (38%), Positives = 157/317 (49%), Gaps = 21/317 (6%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG---- 57 N L I TR S LAL QA V+ L +P L V + T GD D PLA V Sbjct: 3 SKNTLIIGTRGSALALAQADMVRAALSLRYPELDVRCEIIHTIGDRRTDVPLADVARVSG 62 Query: 58 --GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS 115 KG+F+KELE AL + R D+AVHS+KDVP E G L + R D ++ D Sbjct: 63 MVDKGIFIKELETALRDGRIDVAVHSLKDVPSELAAGFTLAAVLPRAAVEDVLITKEPDW 122 Query: 116 LDALPAGSIVGTSSLRRQCQLAERR-PDLIIRSLRGNVGTRLSKL-DNGEYDAIILAVAG 173 + + T S+RR+ L +LRGNV TRL KL ++ +DA+ILA AG Sbjct: 123 NGS----GTLATGSVRRRLMARTYWGSGLRFENLRGNVPTRLGKLVEHPGWDAVILARAG 178 Query: 174 LKRLGLESRIR---------AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224 L+RLGL + LP E+ +PAVGQG VG+ECR D T E+L +N E+ Sbjct: 179 LERLGLYAPETLVEGRKLYMRPLPVEVFIPAVGQGIVGMECRSSDRETAEMLEGINDPES 238 Query: 225 ALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAE 284 AERA RL C P+G YA E+ LRA P + RG + E Sbjct: 239 FACALAERAFLVRLGANCSTPVGVYAHPDGEELVLRAAYYVPGREEPFAVVIRGDRKAPE 298 Query: 285 QMGISLAEELLNNGARE 301 +G+ EEL +G R+ Sbjct: 299 ALGLRAFEELGLSGWRK 315 >UniRef50_A2SQU4 Uroporphyrin-III C-methyltransferase n=11 Tax=Euryarchaeota RepID=A2SQU4_METLZ Length = 542 Score = 305 bits (783), Expect = 1e-81, Method: Composition-based stats. Identities = 119/308 (38%), Positives = 165/308 (53%), Gaps = 22/308 (7%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 + +RI TR S LAL Q V L + G+ E V + T GD + D L ++GG G+FV Sbjct: 2 SKIRIGTRGSKLALAQTKKVIGLLAEN--GIDAEYVIIKTTGDKVTDRGLHQIGGFGMFV 59 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 +EL+ A+L D AVHSMKD+P E P+GL V + +R+ P D V N ++ L Sbjct: 60 RELDNAILRGEIDCAVHSMKDIPAERPKGLLTVAVLKRDPPYDFLVMN--GKVEDL---M 114 Query: 124 IVGTSSLRRQCQLAERR---PDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 ++GTSSLRR+ QL P + + LRGN+ TRL KLD+G YD I++A AGL RL + Sbjct: 115 VIGTSSLRRKAQLLRYFHNCPAVRVEMLRGNLDTRLGKLDDGLYDGIMVAEAGLMRLDYK 174 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R L P++ +PA QG + I R D R A LN ++AL ER + ++ G Sbjct: 175 -RNGVRLSPDMFVPAANQGTIAIVSR-DTPELRAAFAPLNDPQSALDCAIERIVMEQVGG 232 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-GAPQDAEQMGISLAEELLNNGA 299 GC P+G + E L A V + DG++ R G + A GI L N GA Sbjct: 233 GCFTPMGIFCENQ----HLTAEVLSLDGTRAERITAEIGDLEGARVAGI----RLKNVGA 284 Query: 300 REILAEVY 307 E++AE Sbjct: 285 -ELIAEAK 291 >UniRef50_A6LKX0 Porphobilinogen deaminase n=1 Tax=Thermosipho melanesiensis BI429 RepID=A6LKX0_THEM4 Length = 279 Score = 305 bits (781), Expect = 2e-81, Method: Composition-based stats. Identities = 94/247 (38%), Positives = 141/247 (57%), Gaps = 6/247 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +R+ TR+S LAL Q V +KL P + E+ P+VT+GD L TP+ K+GGKG+FV Sbjct: 2 KIRVGTRKSKLALIQTQLVVNKLKELLPNIDFEITPVVTKGDR-LKTPIDKIGGKGVFVS 60 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 ++E +L+++ DIA+HSMKD+P + P L L ++ +RE P D F+ + L G+ Sbjct: 61 DIEKLILDDKLDIAIHSMKDLPSKIPDKLFLTSVLKRECPNDVFIGKE--NFFNLKKGAK 118 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSS RR Q+ RPD+ I +RGNV TR+ K+ GE D I++A AG+ RLGL+ +I Sbjct: 119 IGTSSKRRALQINMLRPDIEIVPIRGNVDTRIKKI--GELDGIVIAAAGVIRLGLKDKIT 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSR-TRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 E +PA QG + +E + E+ + +T + ER + + L C Sbjct: 177 NLFEFEKIVPAPCQGILALEFSEKFLKPFEEIKDVIVDPKTEVETQIERKILSLLNFDCN 236 Query: 244 VPIGSYA 250 P G Y Sbjct: 237 TPFGFYC 243 >UniRef50_Q6L2G8 Probable porphobilinogen deaminase n=1 Tax=Picrophilus torridus RepID=HEM3_PICTO Length = 282 Score = 304 bits (779), Expect = 3e-81, Method: Composition-based stats. Identities = 105/255 (41%), Positives = 151/255 (59%), Gaps = 8/255 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LA+ QA VKD+L + G+ E+ ++GD+ LD+PL +GG G+FV + Sbjct: 3 IRIGTRSSKLAMIQAMMVKDRLDSL--GIETEVKGFTSKGDINLDSPLYSIGGTGVFVDD 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L +L+N DIAVHS KD+P L + + +R+DPRD +S + SL+ L A S++ Sbjct: 61 LNRMILKNEIDIAVHSAKDIPSFIDDSLEISAVLKRDDPRDVLISQH--SLNDLEASSVI 118 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR +L R D++I+ LRGN+ TRL KLDNG+YD II+A A R+ +R Sbjct: 119 GTSSLRRIKELKTLRNDILIKDLRGNIDTRLKKLDNGDYDGIIMAKAAYDRM-RINRRHF 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L + +PA QG + I DS ++L +N ET + AER + + L GC P Sbjct: 178 ILNYDDFVPAPNQGIIAI-ISKKDSEINDVLKKINDDETYNDMKAERLILSGLNLGCSKP 236 Query: 246 IGSYAELIDGEIWLR 260 +G YA I++R Sbjct: 237 VGIYAH--KNRIFMR 249 >UniRef50_C7DH16 Porphobilinogen deaminase n=1 Tax=Candidatus Micrarchaeum acidiphilum ARMAN-2 RepID=C7DH16_9EURY Length = 301 Score = 303 bits (777), Expect = 5e-81, Method: Composition-based stats. Identities = 108/306 (35%), Positives = 169/306 (55%), Gaps = 7/306 (2%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M ++ + I TR S LA+ QA V++KL A P + +V + T + + D A+ K Sbjct: 1 MSESEITIGTRGSELAVAQAEIVRNKLAAIEPRISFRIVKIKTLNEKV-DRSKART-EKD 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 ++ KE++ A+LE R DIAVHS+KD+ + + + + +R+DPRD F+ N + L Sbjct: 59 IYTKEIDEAILERRIDIAVHSLKDLKFNMDENMQIGAVPDRDDPRDVFIGNTETEFEHLG 118 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 ++VGTSS+RR+ QL P +I L GN+ TRLSKL++GE+ I++A AG+KRLG Sbjct: 119 TDALVGTSSIRRRVQLTRINPKPMISDLHGNIDTRLSKLNSGEFSGIVIAAAGVKRLGKA 178 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R+ +PA+GQGA+ + D+S ELL +++ + + V E Sbjct: 179 VRM-QYFDERDVVPAIGQGAIAVTVHKDNSAAAELLKRIDNMKARVEVGEEIEFGKAFGT 237 Query: 241 GCQVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GC +PIG+ A+ L G+I + V G +++GE P A G SLAE L+ GA Sbjct: 238 GCNLPIGANAKMLESGKIGIVGFVSDLAGKTLVKGETETGPGHA---GKSLAELLIKKGA 294 Query: 300 REILAE 305 ++ Sbjct: 295 GNLIER 300 >UniRef50_C6V4N6 Porphobilinogen deaminase n=2 Tax=Neorickettsia RepID=C6V4N6_NEORI Length = 286 Score = 303 bits (777), Expect = 5e-81, Method: Composition-based stats. Identities = 113/292 (38%), Positives = 163/292 (55%), Gaps = 9/292 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L++ R S LAL QA V+ L + LV + T GD++ D PL +VGGK LF+KE Sbjct: 4 LKVGARCSTLALAQARLVERALAPYCERID--LVGVRTSGDILSDIPLTEVGGKALFLKE 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE LL DIAVHSMKDVP + L +V + +R P D FVS Y ++ +LP+G+++ Sbjct: 62 LEEKLLTGEIDIAVHSMKDVPAFYHDDLEVVPVLKRAIPNDVFVSFRYPNMLSLPSGAVI 121 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT + RR QL +R + LRGN+ TR+ K N D IILA GL+RLGL I Sbjct: 122 GTCAPRRVVQLNQRF---RVIPLRGNIATRVEKAKN--LDGIILAFCGLERLGLCKMISE 176 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 + ++ LP V QGA+ +E R D REL+ ++ ET + TAERA + G C+ Sbjct: 177 VIHEDVMLPGVAQGALCVEFRKKDHFLRELILNISDRETIICTTAERAFLEEINGDCKTA 236 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 +G+ A + + ++ ++G + R G+ +A+Q+G S A LL Sbjct: 237 LGALAVVKNNTLYFTGMLGKDNRPCYFRTS--GSCLNAKQIGRSAALALLRM 286 >UniRef50_B3LB83 Porphobilinogen deaminase, putative n=1 Tax=Plasmodium knowlesi strain H RepID=B3LB83_PLAKH Length = 449 Score = 303 bits (776), Expect = 7e-81, Method: Composition-based stats. Identities = 102/382 (26%), Positives = 168/382 (43%), Gaps = 73/382 (19%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHP----GLVVELVPMVTRGDVILDTPLAKVGGK 59 + I TR SPLA+ Q+ V+ KL A + + L + T GD ILD + GGK Sbjct: 65 KEIIIGTRDSPLAIKQSEKVRTKLEAYFKKVNKNVKITLKSIKTMGDNILDQKVDLFGGK 124 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 G+F KEL+ L++ + I VHS+KDVP+E P+ + L +R+ DAF+S Y +L+ + Sbjct: 125 GIFTKELDEELIKGKVHICVHSLKDVPMELPEQVQLSCFLKRDTINDAFLSVKYGTLEDM 184 Query: 120 ---------------PAGS------------------------IVGTSSLRRQCQLAERR 140 P G +GTSSLRR Q+ + Sbjct: 185 NKMKMANKMEEGSYQPKGMSQRVINQNVKRDNYEGDHYDNFIPTIGTSSLRRSSQIKYKY 244 Query: 141 PDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL----------------------- 177 ++ ++++RGN+ TR++KL NG+YDAII+A GL+RL Sbjct: 245 KNVAVKNMRGNINTRIAKLCNGQYDAIIIAKCGLERLTTKKGIRNIIGGKNKVTPKNFLI 304 Query: 178 -------GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTA 230 L S + PA+ QG + + D ++L +N + + Sbjct: 305 NYNNTEINLTSLHIQQINKRTIYPALCQGIIAVSSHKSDKYISDVLKNINDEKAQIMANI 364 Query: 231 ERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISL 290 ER+ ++EG C +PIG YA++++GEI A++ G + G + ++ + Sbjct: 365 ERSFLYQIEGNCMMPIGGYAKIVNGEIVFNAVINDIHGREKYHVREVGKVESYNEIAVMA 424 Query: 291 AEELLNNGAREILAEVYNGDAP 312 A ++ ++ A Sbjct: 425 ATKMKEKIGTHRFNKIREEAAQ 446 >UniRef50_D1B7N1 Porphobilinogen deaminase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B7N1_THEAS Length = 307 Score = 303 bits (776), Expect = 7e-81, Method: Composition-based stats. Identities = 114/298 (38%), Positives = 159/298 (53%), Gaps = 12/298 (4%) Query: 10 TRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVA 69 TR SPLA+ QA KD++ + G V L+ + T GD LA GG G FVK LE Sbjct: 8 TRSSPLAMAQARMWKDRIESL--GHSVRLLDVSTHGDRDRRRHLACFGGFGAFVKALEDR 65 Query: 70 LLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSS 129 LL + AVHS+KDVP P GL + + ER D V+ SL+ LP+G+++GTSS Sbjct: 66 LLSGQGHGAVHSLKDVPSVQPDGLVIAGVLERGPRGDVLVTREGLSLEELPSGAVIGTSS 125 Query: 130 LRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPP 189 +RR Q+ R DL + RGNV +RL KL+ G + I+LA AGL+RLG IRA + Sbjct: 126 IRRAAQVRMLRGDLNVECCRGNVHSRLRKLEQGLFHGIVLARAGLERLG----IRAPMAE 181 Query: 190 EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSY 249 + + GQGAV +E R S L A L H T L V AER+ GC P+ + Sbjct: 182 LPFITSPGQGAVALEAREG-SELHLLGARLTHRSTWLEVLAERSFLKAFGMGCSAPVAAS 240 Query: 250 AELIDGEIWLRALVGAPDGSQIIRGERRGAP---QDAEQMGISLAEELLNNGAREILA 304 A + + L+ V +P+G+ E P +DA +G + E+ +G+ E+L+ Sbjct: 241 AVMDRDTLTLKVQVLSPNGTSAAEAEVSCVPWGEEDAYALGEAAFREI--SGSPEVLS 296 >UniRef50_Q5KKQ0 Hydroxymethylbilane synthase, putative n=2 Tax=Filobasidiella neoformans RepID=Q5KKQ0_CRYNE Length = 481 Score = 302 bits (773), Expect = 2e-80, Method: Composition-based stats. Identities = 105/289 (36%), Positives = 141/289 (48%), Gaps = 37/289 (12%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPG-------------------------LVVE 37 N + TR+S LAL Q +V D L H G Sbjct: 30 TNTFILGTRKSNLALVQTGHVADDLRRLHSGAGSKFGETREEGDDAEQGDVPFVHPYTFS 89 Query: 38 LVPMVTRGDVILDTPLAKV-------GGKGLFVKELEVALLENRADIAVHSMKDVPVEFP 90 + M T GD TPL + K L+ ELE L+ D+ VHS+KDVP Sbjct: 90 IESMTTVGDRNQTTPLHLLSPYSSTQPAKSLWTDELEARLINGHFDMLVHSLKDVPTVLK 149 Query: 91 QGLGLVTICEREDPRDAFVSNNY---DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRS 147 G + + +R DPRDA V L+ LP G++VGT S+RR QL P+L+ Sbjct: 150 DGCEIGCMAKRHDPRDALVVKQGLPYKRLEDLPDGAVVGTGSVRRVAQLKRAFPNLVFED 209 Query: 148 LRGNVGTRLSKLDNGE--YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIEC 205 +RGN+ TR +KLDN + + A+ILA++GL+RLG+ R + L + AVGQGA+ IE Sbjct: 210 MRGNLNTRFNKLDNPQSPFSALILAMSGLERLGMAHRATSPLSSPTLMHAVGQGALAIEI 269 Query: 206 RLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID 254 R D R R L L H +T AER LEGGC VP+G +EL++ Sbjct: 270 RSTDPRVRNCLRGLGHWQTEWSCGAERGCLRVLEGGCSVPVGVESELVE 318 Score = 48.2 bits (114), Expect = 4e-04, Method: Composition-based stats. Identities = 17/57 (29%), Positives = 26/57 (45%), Gaps = 4/57 (7%) Query: 256 EIWLRALVGAPDGSQIIRGE----RRGAPQDAEQMGISLAEELLNNGAREILAEVYN 308 ++ L + V + DGS+ + + + AEQ G A L GA EIL E+ Sbjct: 386 KLTLHSCVTSTDGSKHVLFTPPPVLVRSYRQAEQFGEECARRLRGMGAGEILDEINK 442 >UniRef50_Q0ATQ1 Porphobilinogen deaminase n=3 Tax=Alphaproteobacteria RepID=Q0ATQ1_MARMM Length = 321 Score = 302 bits (773), Expect = 2e-80, Method: Composition-based stats. Identities = 129/305 (42%), Positives = 165/305 (54%), Gaps = 14/305 (4%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASH------PGLVVELVPMVTRGDVILDTPLAKV 56 L IATR+SPLAL QA V+ KL A ++ +V+ GD I D L + Sbjct: 5 SRPLAIATRRSPLALVQARDVQAKLAAQCGLSGEDAERCFPILGLVSTGDRIQDRTLIEA 64 Query: 57 GGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS- 115 GGKGLF KE++ A L+ RA AVHSMKDVP P G+ L + EREDPRD ++ + ++ Sbjct: 65 GGKGLFTKEIDEAQLDGRAAFAVHSMKDVPTVLPDGIVLGALLEREDPRDMLIARDGETR 124 Query: 116 LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLK 175 L LP G +GT+SLRRQ QL +RPDL + LRGNV TRL KL +G A LA AGL Sbjct: 125 LADLPEGVTIGTASLRRQAQLLHKRPDLHVVPLRGNVDTRLGKLADGGIHATFLARAGLN 184 Query: 176 RLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235 RLG +R L + LPA QGAVG+ R D +A L+H +T L V AERA Sbjct: 185 RLGRAEALRDPLEADEMLPAAAQGAVGVAIRDGDEEAASYVAGLHHRDTELAVLAERAFL 244 Query: 236 TRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-----GAPQDAEQMGISL 290 L+G C+ PI ++ + + V PDG Q R + R P A Q G L Sbjct: 245 FELDGSCRTPIAAH--VNKVSMDFIGEVLTPDGQQSWRRQIRFDMTHATPDSARQAGQDL 302 Query: 291 AEELL 295 + Sbjct: 303 GRAVR 307 >UniRef50_B5GJG2 Porphobilinogen deaminase n=3 Tax=Streptomyces RepID=B5GJG2_9ACTO Length = 335 Score = 300 bits (770), Expect = 3e-80, Method: Composition-based stats. Identities = 113/309 (36%), Positives = 153/309 (49%), Gaps = 12/309 (3%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTP----LAKVGGK 59 + + +R S LA Q + ++ PG+ + GD TP + + G Sbjct: 31 RTVTVGSRGSALARAQVREMVERWEREVPGVRFVRRVITEAGDADRSTPTVAGVTRRAGV 90 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTIC-EREDPRDAFVSNNYDSLDA 118 F E AL+ D+ VH +KD+P G L+ RED RDA +L Sbjct: 91 SAFSSRQEAALVRREVDVVVHCLKDLPTTPAPGTALLRTPGPREDARDALC---GATLAG 147 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 LP G+ VGT S RR QL RPDL + +RGNV RL++L DA++LA AGL RLG Sbjct: 148 LPRGARVGTGSTRRVAQLLALRPDLEVIPVRGNVPARLARLRT--LDAVVLAAAGLHRLG 205 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 L I L PE PA GQGA+ I+ R S LLAA T V AER + L Sbjct: 206 LTEEITEYLDPEAYPPAPGQGALAIQVREG-SGAARLLAASGDPATDTEVRAERVLLAEL 264 Query: 239 EGGCQVPIGSY-AELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 GGC VP+G++ + G + L A V APDG + I +G + +++ +++AE LL Sbjct: 265 HGGCSVPLGTWTSRPSPGTLRLHAAVTAPDGGRQITATAQGPASEPDKLALTVAERLLAG 324 Query: 298 GAREILAEV 306 GA ILAE Sbjct: 325 GAARILAEA 333 >UniRef50_C7M2H5 Porphobilinogen deaminase n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7M2H5_ACIFD Length = 291 Score = 300 bits (768), Expect = 5e-80, Method: Composition-based stats. Identities = 123/299 (41%), Positives = 171/299 (57%), Gaps = 14/299 (4%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +RIATR+S LA WQA V ++L ELV + T GD + LA++GG+G+FVK Sbjct: 3 PVRIATRRSALARWQASLVGERLGR------YELVEVHTAGDRDQASSLAEIGGQGVFVK 56 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E++ A++ ADIAVHS KD+P L L + ER D RDA V L+ L G+ Sbjct: 57 EVQAAVVRGEADIAVHSAKDLPTAAGP-LLLAAVLERADARDAIV---GARLEELAIGAR 112 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGTS+ RR QL RPDL + S+RGN+ TRL ++ GE DAI++AVA L+RLGLE Sbjct: 113 VGTSAPRRAAQLRLLRPDLEVVSIRGNIATRLGRV--GELDAIVMAVAALERLGLEEPPW 170 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 LP E+ P GQGA+ +EC D E L +L+ + + AERA+ GC + Sbjct: 171 WPLPEEVLCPQAGQGAIAVECAPDADGLIERLRSLDDDRSRREIEAERAVLAAFGTGCAL 230 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 P+G+ A + LRA+ PDG++ + ER G D +G ++AE L GA ++ Sbjct: 231 PLGARAHADGSSLRLRAVAVDPDGTRQLEVEREGV--DPATLGATVAEVLRRLGADALV 287 >UniRef50_Q1AUK3 Porphobilinogen deaminase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=HEM3_RUBXD Length = 305 Score = 299 bits (767), Expect = 8e-80, Method: Composition-based stats. Identities = 134/306 (43%), Positives = 175/306 (57%), Gaps = 5/306 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + L + TR SPLAL QA L A+ G VEL + T D D PL+ + + + Sbjct: 1 MAGRLVLGTRGSPLALAQAEACAAGLRAA--GFAVELRRIRTTSDRRPDDPLSVIDQRDV 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F ++L+ ALL D+AVHSMKDVP E P+G+ L + R DP DA VS +D LP Sbjct: 59 FTRQLDEALLAGEVDLAVHSMKDVPTEVPEGIVLAAVAGRADPSDALVSEGGWGVDGLPE 118 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ V TSSLRR+ QL RRPDL + +RGNV TR+ K+ G +A++LA AGL RLGLE Sbjct: 119 GARVATSSLRRRAQLLHRRPDLRVVEIRGNVDTRIRKMRAGAAEAVVLARAGLVRLGLE- 177 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 A +P ++ LPAVGQGA+ + R D R E+ ALN V AERA+ LEGG Sbjct: 178 VPHAVIPHDVLLPAVGQGALAVAVRRGDPRLEEIRRALNDPAAEREVAAERALLRALEGG 237 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 C+VP+G+ A + LR +V +PDG+ + GE RG + LA LL GA Sbjct: 238 CRVPVGARAVAGGRGVLLRGVVVSPDGAALCGGEERGEEPEEVG--RRLAARLLERGAAG 295 Query: 302 ILAEVY 307 IL V Sbjct: 296 ILGFVR 301 >UniRef50_A4YD92 Probable porphobilinogen deaminase n=1 Tax=Metallosphaera sedula DSM 5348 RepID=HEM3_METS5 Length = 290 Score = 298 bits (764), Expect = 2e-79, Method: Composition-based stats. Identities = 110/297 (37%), Positives = 153/297 (51%), Gaps = 14/297 (4%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +RIA R S L+L Q V L A G E + + T+ D+ + PL ++G KG+F K Sbjct: 2 KIRIAARGSKLSLKQVEIVTTYLQAK--GYETEFIEIKTKADLFGNKPLHEIG-KGVFEK 58 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E+ A+L+ RADIAVHSMKD+ E P GL L+ +RE+P D VS +L+ LP S Sbjct: 59 EVNEAVLQGRADIAVHSMKDMSSELPPGLELLATPKRENPVDVLVSE--LNLEELPEKSR 116 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GT SLRR L RPDL++ ++RGNV TRL K + EYD IILA AGL+RLG+E + R Sbjct: 117 IGTGSLRRANFLKVVRPDLVVENIRGNVDTRLRKYRDHEYDGIILAEAGLRRLGVEVK-R 175 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L E P QG + + + L LN T AE+ + GGC Sbjct: 176 FPLDVESFTPEPNQGIIAVV---GSPKFLGLFQELNDTGTMKEALAEKETVKVVGGGCHS 232 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRG---ERRGAPQDAEQMGISLAEELLNNG 298 P+G L D L + +G + + R Q+G +L + + + G Sbjct: 233 PLGVLFRLEDDV--LHGIASYSNGVKRVTVKLSTRESPQIAGNQLGKALVKAMKDEG 287 >UniRef50_C7R376 Porphobilinogen deaminase n=1 Tax=Jonesia denitrificans DSM 20603 RepID=C7R376_JONDD Length = 344 Score = 298 bits (763), Expect = 2e-79, Method: Composition-based stats. Identities = 126/344 (36%), Positives = 172/344 (50%), Gaps = 47/344 (13%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LR+ TR S LA Q+ L+A G+ V+L + T GD +L LA +GG G+FV Sbjct: 4 LRLGTRASALATAQSRATA-ALIAQATGVTVDLTHIRTDGD-VLTGSLATMGGAGVFVTA 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 + ALL DIAVHS+KD+P +G ++ + ERE+P+DA S + +SL LP G++V Sbjct: 62 IRQALLAGDIDIAVHSLKDLPTTPHEGTTII-VPERENPQDALCSRHGESLAHLPHGALV 120 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD---------NGEYDAIILAVAGLKR 176 GT S RR QL RPDL I +RGNV TRL+++ + DA++LA AGL+R Sbjct: 121 GTGSPRRAAQLLVARPDLRIVDIRGNVDTRLARVGLSTADKPHIRNDLDAVVLAAAGLRR 180 Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSR----TRELLAALNHHETALRVTAER 232 LG I LPP LPA GQGA+ IE R D + + L+H TA V AER Sbjct: 181 LGRAHVISELLPPTSMLPAPGQGALAIEVRHDMADHHPSILAGIRTLHHQPTAYAVAAER 240 Query: 233 AMNTRLEGGCQVPIGSYAEL-----------IDGEIWLRALVGAPDGSQII--------- 272 A+ LE GC P+G+ A + +D + A P + I Sbjct: 241 AVLRHLEAGCAAPVGALATMHNTTLTLTATALDPRLTPTAHTPTPSTTTDINAAPTPMTA 300 Query: 273 -----------RGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 + DA + GI+LA LL +GA E L + Sbjct: 301 PADARPPIRLTHTHTVTSENDATEAGITLATTLLTHGAAEFLRD 344 >UniRef50_D1JID7 Porphobilinogen deaminase n=1 Tax=uncultured archaeon RepID=D1JID7_9ARCH Length = 290 Score = 297 bits (761), Expect = 3e-79, Method: Composition-based stats. Identities = 97/295 (32%), Positives = 153/295 (51%), Gaps = 11/295 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 + + TR S LAL Q V ++L G+ E+ + + GDV+ D L ++ G+FVK+ Sbjct: 1 MIVGTRGSNLALVQTKKVCERLSEL--GVECEIKTVQSLGDVMTDRGLYEMPTIGVFVKK 58 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L++ LL+ + DIAVHSMKD+P E + L + R+ P DA VS LD +P G+++ Sbjct: 59 LDMMLLDAKIDIAVHSMKDMPSEREEELDTSAVLPRDSPYDALVSR--YRLDDMPEGAVI 116 Query: 126 GTSSLRRQCQLAER----RPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 GTSS+RR+ Q + I+ +RGNV TR++K GEYD++ILA AG +RL L+ Sbjct: 117 GTSSVRRRYQFLNYVGERGVKVTIKDIRGNVDTRIAKFRRGEYDSVILAEAGFERLKLDI 176 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 L + +P+ QG + + R E+L ++ ET + E + + GG Sbjct: 177 EY-ERLDRDPFVPSPRQGIIAVVARRGSKE-SEILKQIDDSETRIEAEVEEEVLKVIGGG 234 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 C +P+G +A G + L V A D + G E+ LA++ + Sbjct: 235 CSLPVGVHATAKGGSVELAVYVAASDVRYKLEKVVLGKDYYMEET-RELAQKFKS 288 >UniRef50_C4JRY9 Porphobilinogen deaminase n=1 Tax=Uncinocarpus reesii 1704 RepID=C4JRY9_UNCRE Length = 287 Score = 296 bits (758), Expect = 8e-79, Method: Composition-based stats. Identities = 107/318 (33%), Positives = 154/318 (48%), Gaps = 58/318 (18%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 I TR+SPLAL Q V+ L ++P Sbjct: 7 KTYTIGTRKSPLALVQTDLVRRALQTAYPN------------------------------ 36 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLDALP 120 D+ VH VP + P L + RE+PRD V +L LP Sbjct: 37 -----------CDLKVHG--HVPTQIPDACVLGAMMPRENPRDVLVIKKGLPWMTLAELP 83 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLKRLG 178 AGS+VGTSS+RR QLA P L+++ +RGN+ TRL+KLD +G + +I+A AGL R G Sbjct: 84 AGSVVGTSSVRRTAQLARHYPHLVVQDIRGNIDTRLAKLDAEDGPFTCLIMAAAGLLRTG 143 Query: 179 LESRIRAALPPE--ISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236 E+R+ L + L AVGQGA+GIE R DD ++++ + T AER + Sbjct: 144 HENRVTQYLDSKNGKMLHAVGQGALGIEVRTDDEVMKDMVNKIGDMPTTYACMAERNLLR 203 Query: 237 RLEGGCQVPIGSYAELIDGE-----IWLRALVGAPDGSQIIRGERRGA---PQDAEQMGI 288 +EGGC P+G E I + + LRA+V + DG + + E+ G ++AE G Sbjct: 204 TVEGGCSAPLGVETEWIQDDNGKSLLRLRAIVVSVDGKEAVELEKDGDVESIEEAEAFGK 263 Query: 289 SLAEELLNNGAREILAEV 306 +A EL++ GA +IL E+ Sbjct: 264 QVALELIDKGAGKILEEI 281 >UniRef50_A9HK97 Porphobilinogen deaminase n=12 Tax=Acetobacteraceae RepID=A9HK97_GLUDA Length = 367 Score = 295 bits (757), Expect = 1e-78, Method: Composition-based stats. Identities = 132/312 (42%), Positives = 166/312 (53%), Gaps = 21/312 (6%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLV----VELVPMVTRGDVILDTPLAKVGGKG 60 LR+ TR SPLAL Q L P L + + T GD + + LA++GGKG Sbjct: 46 PLRVGTRASPLALVQTRAFLTMLTRFCPVLRDMGAFQEHQINTTGDQVQNRRLAEIGGKG 105 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD------ 114 LF KE+ AL + R D AVHS+KD+ P GL L RED RDA + Sbjct: 106 LFAKEIHDALSDGRIDFAVHSLKDLETTLPPGLVLACTLRREDARDALILGPGAGGRHDA 165 Query: 115 -----SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIIL 169 ALP ++VG +S+RRQ Q+ RPDL LRGNV TRL KL + DA +L Sbjct: 166 ADAADPYAALPRNALVGCASVRRQAQMLHVRPDLRFGLLRGNVQTRLDKLAARQCDATLL 225 Query: 170 AVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVT 229 A+AGL+RLG+E R L PEI +PA GQG VG+ R D RELLAA+ +E T Sbjct: 226 ALAGLRRLGMEDRADIVLDPEIMVPAAGQGIVGVTVRESDVELRELLAAIEDYEARAVAT 285 Query: 230 AERAMNTRLEGGCQVPIGSYAELIDG------EIWLRALVGAPDGSQIIRGERRGAPQDA 283 AERA+ L+G C+ PIG YA L+ G + L LV DGS ++R G DA Sbjct: 286 AERALLAELDGSCRTPIGGYARLVPGLAGAEASLRLTGLVAREDGSFLLRRTVTGLRADA 345 Query: 284 EQMGISLAEELL 295 E+MG L L Sbjct: 346 EEMGRELGRSLR 357 >UniRef50_B5JN62 Porphobilinogen deaminase n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JN62_9BACT Length = 291 Score = 295 bits (757), Expect = 1e-78, Method: Composition-based stats. Identities = 112/294 (38%), Positives = 143/294 (48%), Gaps = 16/294 (5%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 IATR+SPLA+ Q H K+ P V + MVT GD + L K GGKGLF Sbjct: 6 REYVIATRKSPLAMAQTHLAKELFQRGMPDAVFRIEKMVTTGDKRQEWSLEKQGGKGLFT 65 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE ALLE RAD AVHS KD+P E P+GL L R+ D + + L Sbjct: 66 KELEDALLEGRADFAVHSAKDLPSEMPKGLALAGFLPRQTCEDVLILRDGVESPKL---- 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG---LE 180 + T S RR+ QL P +RGNV TRL+K+ G+ DA +LA AGL RLG E Sbjct: 122 -IATGSPRRRIQLRYLFPKAEFTEIRGNVDTRLTKIARGDADATVLASAGLNRLGIESWE 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 L + +PAVGQ AV I+CR +D T A ETA+ V ER+ L G Sbjct: 181 GVTFRKLTLDECVPAVGQAAVAIQCREEDVDT---FRAHLDEETAIAVNLERSFLEELGG 237 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 GCQV + G + + G ++ + EQ+ L E+L Sbjct: 238 GCQVAFAV--NYVGGRLRI---YHKQCGKEVRDLPQEYVATHYEQIAAKLIEQL 286 >UniRef50_Q2FTK7 Hydroxymethylbilane synthase n=3 Tax=Methanomicrobiales RepID=Q2FTK7_METHJ Length = 295 Score = 293 bits (752), Expect = 4e-78, Method: Composition-based stats. Identities = 111/306 (36%), Positives = 163/306 (53%), Gaps = 19/306 (6%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LR+ TR S LA QA V L G+ ELV + T GD PL ++GG+G+FV+ Sbjct: 2 PLRVGTRASELAKAQAVKVCTMLEDL--GVDTELVFISTAGDEQTGVPLHEIGGQGVFVR 59 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L+ AL++N+ D+AVHSMKD+P E P GL I R+ P D V+++ L + Sbjct: 60 ALDDALVQNKIDLAVHSMKDIPAERPYGLVTSAILARDSPCDYIVTDH-----ELDEITT 114 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSS RR Q P IR LRGNV TRLSKL +GEYDAI+LA AGL+RL + Sbjct: 115 LGTSSTRRTAQCRRNLPWADIRPLRGNVNTRLSKLQSGEYDAIMLAKAGLERLSMTLDGY 174 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L P + +P+ QG + + R D ++++ ++ +T + ER + + GGC Sbjct: 175 Q-LDPRVHVPSPNQGTIAVVSRT-DPDVTDIISKIDDPKTRMDTLLERRVMEMIGGGCFT 232 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGER-RGAPQDAEQMGISLAEELLNNGAREIL 303 P+G Y + + A V + +G + R ER DA++ G+ + E A +++ Sbjct: 233 PLGIYCKDR----LMIAEVLSLEGDRHFRLERLVSDIDDADRFGLEVRER-----AGDLI 283 Query: 304 AEVYNG 309 E Y Sbjct: 284 REAYER 289 >UniRef50_C3MZR8 Probable porphobilinogen deaminase n=11 Tax=Sulfolobus RepID=HEM3_SULIA Length = 293 Score = 293 bits (751), Expect = 5e-78, Method: Composition-based stats. Identities = 97/293 (33%), Positives = 147/293 (50%), Gaps = 9/293 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +RIA R S L+ Q + +KL G+ E++ + T+ D+ PL+K+G KG+F K Sbjct: 2 KIRIAARGSKLSRIQVDMLGEKLKKI--GIEYEIIDIKTKADLFSTEPLSKLG-KGVFEK 58 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E+ A+LE +ADIAVHSMKD+ E L + + ER+ P D ++ +LD L + Sbjct: 59 EVNEAVLEGKADIAVHSMKDILSEINPSLEIFAVLERDPPYDILIAEK--NLDKLDSNIT 116 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSS+RR+ L +P++ + +RGNV TR+ K + EY +ILA A LKRL + Sbjct: 117 IGTSSIRRKNFLKYIKPEINTKDIRGNVDTRIRKYLSKEYQGLILAEASLKRLNMTMNYH 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 + P QG + R D + +E+ +NH +T AERA+ + + GGC Sbjct: 177 RLNVYD-FTPEANQGIIVALGRKKDEKIKEIFKEINHKDTLDEALAERAVISLVGGGCHS 235 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 PIG + E + DG + I P D +G L L Sbjct: 236 PIGVLFKKEGKE--FYGIASYSDGKKKITVSIS-KPGDPYTIGSELGLLLKKE 285 >UniRef50_D2RNT2 Porphobilinogen deaminase n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RNT2_ACIFE Length = 288 Score = 292 bits (749), Expect = 8e-78, Method: Composition-based stats. Identities = 117/297 (39%), Positives = 163/297 (54%), Gaps = 14/297 (4%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L +ATR S LAL Q H V L + G+ E+ + T GD L K+GG+G+FV Sbjct: 2 KKLIVATRGSRLALAQTHIVCRLLEEA--GVETEIRTITTAGDRDRIHALVKIGGRGIFV 59 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 +E+E LL ADIAVHS KD+P + GL + + DPRDA V L+ AGS Sbjct: 60 REIERELLSGEADIAVHSAKDLPYQLASGLVIAGTPSQADPRDALVLLKERKLE---AGS 116 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +VGT S RR +++ P+L+ R +RGNV TRL KL+ GEYDAI+LA+AG++RL L+ Sbjct: 117 VVGTGSPRRIREISRVLPELVFRDIRGNVTTRLHKLERGEYDAIVLAMAGIQRLALDMEQ 176 Query: 184 RAA--LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 L E +PA QG +G+ECR D LL ++ ET R ER + T ++ Sbjct: 177 FQIRPLSTEQVIPAGCQGIIGVECRQKDRELVRLLQQISDPETWRRFQWERQLFTSMKVD 236 Query: 242 CQVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 C P+G + L G + L A+V DG + R G ++ + + SL EEL + Sbjct: 237 CSRPVGIHCRLLKSGRMELLAMV---DGKRARRL---GMEKEGKALCASLKEELYDR 287 >UniRef50_C0W553 Porphobilinogen deaminase n=2 Tax=Actinomycetales RepID=C0W553_9ACTO Length = 402 Score = 291 bits (747), Expect = 2e-77, Method: Composition-based stats. Identities = 129/387 (33%), Positives = 176/387 (45%), Gaps = 81/387 (20%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASH----PGLVVELVPMVTRGDVILDTPLAKVGGK 59 + +R+ TR S LAL Q+ V L + L VELVP+ TRGDV T L+++GG Sbjct: 2 STVRLGTRGSALALTQSGLVARMLEQAAALAGQELHVELVPVRTRGDVD-PTALSQLGGV 60 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD-SLDA 118 G+F L ALL D+AVHS KD+P GL + + REDPRD + L Sbjct: 61 GVFATALREALLAGECDLAVHSYKDLPTAAVPGLRIAAVPAREDPRDVLCTRAATLGLHD 120 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--------------DNGEY 164 LPAG+ VGT S RR QL +RPDL I +RGNV TRL+++ + Sbjct: 121 LPAGARVGTGSPRRSAQLLAQRPDLTIVPIRGNVPTRLARVVGSVVSADGPMGATAEPDL 180 Query: 165 DAIILAVAGLKRLGLESRIRAALP---------------------------PEISLPAVG 197 DA ILA++G++RLGLE L LPA Sbjct: 181 DAAILALSGMRRLGLEDYASQPLAARCGARSQVEVQGIPDGGSAAGSPATTEPWMLPAAA 240 Query: 198 QGAVGIECRLDDSRTREL------LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAE 251 QGA+ +E R D + EL LA ++ T AER++ L GC P+G+ A Sbjct: 241 QGALAVETR--DRVSCELPVLTVALALVDDPVTRACADAERSLMRCLAAGCAAPVGALAR 298 Query: 252 LID--------------------------GEIWLRALVGAPDGSQIIRGERRGAPQDAEQ 285 +D I L ALV + DG+Q+ R G ++AE Sbjct: 299 PLDVAGEPAAGRDLPTEPGTALEPGPDQAPAICLEALVASLDGTQLRRASATGTLEEAED 358 Query: 286 MGISLAEELLNNGAREILAEVYNGDAP 312 +G +AE LL +GA +I + +P Sbjct: 359 LGRCVAERLLADGAAQITDLQASKGSP 385 >UniRef50_Q4PFH9 Putative uncharacterized protein n=1 Tax=Ustilago maydis RepID=Q4PFH9_USTMA Length = 770 Score = 291 bits (745), Expect = 3e-77, Method: Composition-based stats. Identities = 115/296 (38%), Positives = 153/296 (51%), Gaps = 39/296 (13%) Query: 34 LVVELVPMVTRGDVILDTPLAKVGGKG--LFVKELEVALLENRADIAVHSMKDVPVEFPQ 91 + M T GD L +PL +GG+G ++ KELEVAL + D VH +KDVP PQ Sbjct: 249 HAFPITSMSTAGDQNLRSPLYVIGGEGKAIWTKELEVALEQGAVDAIVHCLKDVPTALPQ 308 Query: 92 GLGLVTICEREDPRDAFVSNNYDS---LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSL 148 GL L + EREDPRDA V LD LP GS++GTSS+RR QL R P L+ + Sbjct: 309 GLELAAVLEREDPRDALVVKAGLPYKVLDELPVGSVIGTSSVRRVAQLRRRYPHLVFSDV 368 Query: 149 RGNVGTRLSKLD--NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECR 206 RGN+ TRL+KLD NG Y A+ILA AGL RL + +RI A L + L +VGQG++ IE R Sbjct: 369 RGNINTRLAKLDAPNGPYTALILAAAGLVRLNMHARITAFLSSPVLLHSVGQGSLAIEVR 428 Query: 207 L----------DDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGE 256 D+R REL+ ++ R AER++ LEGGC +P+G D Sbjct: 429 TPPEGADPTTNRDARIRELIRSIGDWRATFRAEAERSLLKELEGGCSIPVGVETRFDD-- 486 Query: 257 IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYNGDAP 312 + G +A I+L ++ + G AE+ NG P Sbjct: 487 ----------------HDQVEGQRSEA----IALVDDFVTQGNAGAKAELPNGGMP 522 Score = 48.6 bits (115), Expect = 3e-04, Method: Composition-based stats. Identities = 28/89 (31%), Positives = 39/89 (43%), Gaps = 8/89 (8%) Query: 222 HETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR---G 278 T + AER ++T + S + L A+V + DGSQ R Sbjct: 573 PSTNAQTIAERIVSTSY----SIVDRSTPAPEGRTLHLDAIVVSLDGSQESRYSASKHCT 628 Query: 279 APQDAEQMGISLAEELL-NNGAREILAEV 306 +DA ++GI +A EL GAR IL EV Sbjct: 629 TVKDARELGIHVAHELAHKKGARAILEEV 657 >UniRef50_C8WDJ7 Porphobilinogen deaminase n=3 Tax=Zymomonas mobilis RepID=C8WDJ7_ZYMMN Length = 308 Score = 285 bits (730), Expect = 1e-75, Method: Composition-based stats. Identities = 116/292 (39%), Positives = 162/292 (55%), Gaps = 7/292 (2%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHP--GLVVELVPMVTRGDVILDTPLAKVGGK 59 + R+ +R SPLAL QA V L A+H V +VP+ T GD LA +GGK Sbjct: 1 MQLPFRLGSRGSPLALIQARSVASALCAAHSWSEDAVVIVPIRTSGDKNRHQALADIGGK 60 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 L+ KEL++AL + D AVHSMKDV P + + + RED D + SL+ L Sbjct: 61 ALWTKELDIALTTGQIDAAVHSMKDVETFRPSHISIAAMLPREDVHDRLIG--IPSLEVL 118 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P VGT+S RR Q+ RPD+ I+ LRGN+ TRL KL N ++DA +LA AGL RLG Sbjct: 119 PYSGCVGTASPRRAAQIRRIRPDIEIKLLRGNIDTRLEKLANKQFDATLLAAAGLIRLGR 178 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 + +P + LPA GQGA+GIE DS E ++ ++H+ T L V +ER + RL Sbjct: 179 ND-VGYDVPLDQMLPAAGQGAIGIEALA-DSAAWEKVSIIDHYPTHLAVQSERQLLLRLN 236 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGA-PQDAEQMGISL 290 C PI +AE+++ I LRA + +G ++ + P DA ++G L Sbjct: 237 ADCHSPIAVFAEILEKNIRLRACLYTENGKFSASIDKEISQPSDAFEVGSLL 288 >UniRef50_Q97B26 Probable porphobilinogen deaminase n=2 Tax=Thermoplasma RepID=HEM3_THEVO Length = 297 Score = 284 bits (728), Expect = 3e-75, Method: Composition-based stats. Identities = 86/267 (32%), Positives = 136/267 (50%), Gaps = 6/267 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 ++I TR S LA+ QA+ V L A G+ E+V + GD+ P+ +G G+FV+ Sbjct: 2 KIKIGTRPSNLAVAQANMVASSLEAI--GIDTEIVKHRSAGDIDTKNPIYSIGKTGVFVQ 59 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 +L +L D+AVHS KD+P E L + +R DA VS L +LP + Sbjct: 60 DLNNMILRGEIDVAVHSAKDIPSEIENRLTIAATLKRGSFNDALVSK--YDLRSLPISAK 117 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGTSS+RR QL R DL ++RGN+ TR++K+ DAI++A A ++RLGL Sbjct: 118 VGTSSIRRIFQLKYARQDLKFENIRGNIETRIAKMSELGLDAIVMAEAAIQRLGLNVEYS 177 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L +PA QG + + + + + R++L +N T + ER++ +L+ GC Sbjct: 178 K-LDENKFVPAPNQGIIAVVSKKEGT-VRKILEEINDENTFEEMQIERSVVQQLKLGCST 235 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQI 271 P+G + + A + G + Sbjct: 236 PVGILSRPSGKGHKIIAQFFSMQGDDV 262 >UniRef50_A2BFN7 Hydroxymethylbilane synthase (Fragment) n=6 Tax=Coelomata RepID=A2BFN7_DANRE Length = 247 Score = 283 bits (726), Expect = 4e-75, Method: Composition-based stats. Identities = 112/229 (48%), Positives = 144/229 (62%), Gaps = 4/229 (1%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 V+R+ TR+S LA Q V L +P + +E+V M T GD ILDT L+K+G K LF Sbjct: 19 SRVIRMGTRKSQLARIQTDSVAGTLKQLYPDVHLEIVAMSTIGDKILDTALSKIGEKSLF 78 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDAL 119 KELE AL N DI VHS+KD+P P G + I ERE+P DA V + +LD+L Sbjct: 79 TKELENALERNEVDIVVHSLKDLPTSLPPGFTIGAILERENPHDAVVLHPKNAGLTLDSL 138 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLG 178 P S++GTSSLRR QL +R P L ++RGN+ TRL KLD +Y AIILA AGLKR+G Sbjct: 139 PEKSVIGTSSLRRAAQLKKRFPQLEFENIRGNLNTRLKKLDEKDDYAAIILAAAGLKRMG 198 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALR 227 ESRI L PE + AVGQGA+ +E R D E+++ L+H +T LR Sbjct: 199 WESRISQVLGPEDCMYAVGQGALAVEVRAQDKDILEMVSVLHHPDTVLR 247 >UniRef50_C1XV35 Porphobilinogen deaminase n=2 Tax=Meiothermus RepID=C1XV35_9DEIN Length = 304 Score = 283 bits (725), Expect = 5e-75, Method: Composition-based stats. Identities = 114/270 (42%), Positives = 159/270 (58%), Gaps = 11/270 (4%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + +RIATR S LA WQA +V +L G+ LV + T+GD +++ G+G Sbjct: 1 MSR-VRIATRGSRLARWQAEWVAAQLQDQ--GIASTLVIVETQGDRER-VAFSQMQGQGF 56 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP- 120 F K ++ A+ E RAD+AVHS+KD+P GL L I REDPR+A + P Sbjct: 57 FTKAVQDAVREGRADLAVHSLKDLPSAPTPGLVLAAIPIREDPREALLVLPSAWDAQAPA 116 Query: 121 ----AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKR 176 G+ VG+S++RRQ QLA+ RPDL + LRGNV TR+ KL +G Y+AI+LA AGLKR Sbjct: 117 LPLAPGARVGSSAVRRQAQLAQLRPDLKLLELRGNVPTRVEKLQSGGYEAILLAWAGLKR 176 Query: 177 LGLE--SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234 LGL+ L P +PA GQGA+ +ECR +D++ R +L L+ L V ER + Sbjct: 177 LGLDLGGLAVRLLEPREFVPAPGQGALALECREEDTQLRGVLQGLDDPTARLTVGIERGL 236 Query: 235 NTRLEGGCQVPIGSYAELIDGEIWLRALVG 264 RL+GGCQ+ +G+ A+ + G L A G Sbjct: 237 MARLQGGCQLALGASAQRVQGGWQLLAWYG 266 >UniRef50_C5C5B3 Porphobilinogen deaminase n=6 Tax=Actinomycetales RepID=C5C5B3_BEUC1 Length = 334 Score = 282 bits (722), Expect = 1e-74, Method: Composition-based stats. Identities = 120/294 (40%), Positives = 155/294 (52%), Gaps = 25/294 (8%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASH-----PGLVVELVPMVTRGDVILDTPLAKV 56 LR+ TR S LA Q+ + + + A + VELV + T GD +L LA + Sbjct: 18 STRTLRVGTRASALATTQSEWAGEAIAARVAAATGSDVEVELVRVTTTGD-VLTGSLASM 76 Query: 57 GGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSL 116 GG G+FV L ALL+ R D+AVHS+KD+P GL L + +REDPRD + L Sbjct: 77 GGTGVFVTALREALLDGRCDVAVHSLKDLPTAAAPGLVLGAVPQREDPRDVLCARAGAGL 136 Query: 117 DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGL 174 LPAG VGT S RR QL RPDL I +RGNV TRLS++ G+ DA++LA AGL Sbjct: 137 ADLPAGGRVGTGSPRRAAQLRRARPDLEIVDIRGNVDTRLSRISPGKGDLDAVVLARAGL 196 Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECR-LDDSRTRELLAALNHHETALRVTAERA 233 RLG + AL + +PA GQGA+ +E L A + T L VTAERA Sbjct: 197 ARLGRLDAVTEALDAGVMVPAPGQGALAVEAVDAAPDWLLAGLRAFDDAPTRLAVTAERA 256 Query: 234 MNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMG 287 M RLE GC P+G+ A L ++ LR VG +DAE +G Sbjct: 257 MLARLEVGCSAPVGALATLAGSQLLLRTSVG----------------EDAEDLG 294 >UniRef50_Q8I5V3 Porphobilinogen deaminase n=6 Tax=Plasmodium RepID=Q8I5V3_PLAF7 Length = 435 Score = 281 bits (721), Expect = 2e-74, Method: Composition-based stats. Identities = 95/367 (25%), Positives = 164/367 (44%), Gaps = 61/367 (16%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHP----GLVVELVPMVTRGDVILD-TPLAKVG 57 + + I TR SPLAL Q+ V+ K+M+ + V + T GD ILD + G Sbjct: 59 KDEIIIGTRDSPLALKQSEKVRKKIMSYFKKMNKNINVTFKYIKTTGDNILDSKSVGLYG 118 Query: 58 GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD 117 GKG+F KEL+ L+ D+ VHS+KDVP+ P + L +R+ DAF+S Y S++ Sbjct: 119 GKGIFTKELDEQLINGNVDLCVHSLKDVPILLPNNIELSCFLKRDTINDAFLSIKYKSIN 178 Query: 118 ALPAGS------------------------IVGTSSLRRQCQLAERRPDLIIRSLRGNVG 153 + +GTSSLRR+ Q+ R ++ + ++RGN+ Sbjct: 179 DMNTVKSVSKTEDIHHINKKDSDHNNDTLCTIGTSSLRRRSQIKNRYKNIYVNNIRGNIN 238 Query: 154 TRLSKLDNGEYDAIILAVAGLKRL--------------------------------GLES 181 TR+ KL NGE DA+I+A+ G++RL L Sbjct: 239 TRIEKLYNGEVDALIIAMCGIERLIKKANLKHLLKNKEQKNICQPFLLKCNNKKCIDLCH 298 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 L + PA+GQG + + + LL +N+ ++ + ER+ ++G Sbjct: 299 VNIQKLNKNLIYPALGQGIIAVTSHKKNYFISSLLKNINNKKSEMMAQIERSFLYHIDGN 358 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 C +PIG Y + + +I+L ++ G + ++ + +++G + A ++ E Sbjct: 359 CMMPIGGYTNMRNEDIYLHVIINDIHGYNKYQVTQKDTLYNYKEIGPNAAIKMKEIIGTE 418 Query: 302 ILAEVYN 308 ++ Sbjct: 419 QFNKIKA 425 >UniRef50_B4D5X7 Porphobilinogen deaminase n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4D5X7_9BACT Length = 307 Score = 281 bits (720), Expect = 2e-74, Method: Composition-based stats. Identities = 109/277 (39%), Positives = 149/277 (53%), Gaps = 14/277 (5%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPL---AKVGGKG 60 + + TR S LA+ Q L A+ P + +E VTRGD LD L + GGKG Sbjct: 2 KSIILGTRASALAVAQVELTTKALAAAFPAMQIERREFVTRGDKKLDLSLLRANEAGGKG 61 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF KELE ALL D+AVHS+KD+P P GL + + ER D ++ +L LP Sbjct: 62 LFTKELEDALLNGSIDVAVHSLKDLPGHNPPGLDITAVLERAPTADVLITKQPQTLLDLP 121 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGL 179 G ++GTSS+RR QL RRPD+ + RGNV TRL KL + IILA AGL+RLG Sbjct: 122 QGVLLGTSSVRRARQLQWRRPDVRVEEWRGNVQTRLRKLAERDDVTGIILAQAGLERLGH 181 Query: 180 ESRIRAALPP----------EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVT 229 + E LPA+GQGA+ ++ R D + +L ++H ET L + Sbjct: 182 DLSAGRLETEHGKFYVTSLAEDLLPAIGQGAIALQSRADRAEVAAVLQKIDHRETHLAIR 241 Query: 230 AERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAP 266 AER + L G C +P+G +L+ G I +RA++ P Sbjct: 242 AERELQRLLAGDCALPVGVRTKLLPGGIAMRAILFGP 278 >UniRef50_B0WMK9 Porphobilinogen deaminase n=1 Tax=Culex quinquefasciatus RepID=B0WMK9_CULQU Length = 474 Score = 281 bits (719), Expect = 3e-74, Method: Composition-based stats. Identities = 96/243 (39%), Positives = 133/243 (54%), Gaps = 29/243 (11%) Query: 13 SPLALWQAHYVKDKLMASHPGLVVELV------------------------PMVTRGDVI 48 S LAL Q YV L +P +V E+ M T GD + Sbjct: 167 SKLALIQTKYVISCLQKLNPDVVYEIRKYFQHVHLCWHVPSYLLAFFLSPDTMTTVGDRV 226 Query: 49 LDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAF 108 L+ L K+G K LF K+LE AL D VHS+KD+P P G+ + + ER+DPRDA Sbjct: 227 LNKSLPKIGEKSLFTKDLEDALRTGGVDFVVHSLKDLPTALPLGMAIGAVLERDDPRDAL 286 Query: 109 V---SNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG--E 163 V ++ +L LP GS+VGTSSLRR QLA + ++++ +RGN+ TRL+KLD + Sbjct: 287 VLNEAHRGRTLSTLPKGSVVGTSSLRRSAQLARKYENVVVCDIRGNLNTRLAKLDADGSK 346 Query: 164 YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHE 223 + IILA AGL R+G +R+ + P L AVGQGA+ +ECR +D ++L+ L H E Sbjct: 347 FAGIILAQAGLVRMGWNARVSQVIEPGEILYAVGQGALAVECRSNDEYILDMLSKLCHLE 406 Query: 224 TAL 226 T Sbjct: 407 TQC 409 >UniRef50_Q93A65 Porphobilinogen deaminase n=1 Tax=uncultured bacterium RepID=Q93A65_9BACT Length = 299 Score = 280 bits (717), Expect = 4e-74, Method: Composition-based stats. Identities = 120/296 (40%), Positives = 168/296 (56%), Gaps = 19/296 (6%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +R+ATR S LALWQA +V +L+ G VELV + T+GD P A++ G+G F K Sbjct: 4 VRLATRGSRLALWQAEWVAKQLVQQ--GAEVELVVVETQGDR-EKRPFAQMQGQGFFTKA 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN-----NYDSLDALP 120 ++ A+LE RAD AVHS KD+P P GL + + REDPR+ + L Sbjct: 61 VQEAVLEGRADFAVHSYKDLPSARPAGLEIAAVPPREDPRELLLVRLQAVDQVAPGLPLR 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 AG+ VG+S+ RRQ QLA RPDL + LRGNV TR+ KL GEYDA++LA AG++RLGL+ Sbjct: 121 AGARVGSSAARRQAQLAHLRPDLSLLELRGNVLTRVEKLRQGEYDAVLLAYAGVRRLGLD 180 Query: 181 --SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 LPP + +PA QGA+ +ECR DD R R LL L+ +R + RL Sbjct: 181 LSPFHWQVLPPTLLVPAPAQGALALECRQDDKRLRPLLEPLDDPSAGVRCGGA-GLMARL 239 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 GGCQ+ +G+ A+ + L A + + RG+ D E + ++ +E+ Sbjct: 240 AGGCQLALGALAQETPEGLQLLAWY------RGRSYQARGS--DPEAVAEAVFKEI 287 >UniRef50_Q9Y9J0 Probable porphobilinogen deaminase n=1 Tax=Aeropyrum pernix RepID=HEM3_AERPE Length = 307 Score = 280 bits (717), Expect = 4e-74, Method: Composition-based stats. Identities = 106/294 (36%), Positives = 158/294 (53%), Gaps = 8/294 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVV--ELVPMVTRGDVILDTPLAKVGGKGLFV 63 +R+A R S L+L Q ++L + + G+ + E+V + + GDV D PL +G G+F Sbjct: 3 VRVAARGSRLSLLQVEQALEEL-SRYAGVSMHWEVVRVKSAGDVWSDRPLESIGVVGVFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQG-LGLVTICEREDPRDAFVSNNYD-SLDALPA 121 +E++ A+ ADIAVHS+KD+P G L +V I R RDA +S ++ L Sbjct: 62 REVDRAVASGAADIAVHSLKDMPTSGYGGPLKIVYIASRPSARDALISRQGPGRVEDLEP 121 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 GS +GTSS RR+ P + + +LRGN+ TRL KL G YDAII + AGL RLG++ Sbjct: 122 GSTLGTSSARRRALSLHYNPRIRVENLRGNLDTRLRKLREGLYDAIIASEAGLIRLGVDV 181 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 L P PA GQG V + R+ S ++L L+ AER + G Sbjct: 182 EYT-PLDPSYFPPAPGQGFVAVVARVG-SNVEKMLRDLDKPPWWHVAWAERGVLEGARAG 239 Query: 242 CQVPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 C+ P+ +YAE + + + A +PDGS+ G ++A ++G+SL EEL Sbjct: 240 CRTPVAAYAEPLGRSMVRVTAAALSPDGSRAYWARAEGRIEEARRIGVSLGEEL 293 >UniRef50_Q0RS16 Porphobilinogen deaminase 1 (PBG 1) (Hydroxymethylbilane synthase 1) (HMBS 1) (Pre-uroporphyrinogen synthase 1) n=2 Tax=Frankia RepID=Q0RS16_FRAAA Length = 402 Score = 278 bits (713), Expect = 1e-73, Method: Composition-based stats. Identities = 121/366 (33%), Positives = 168/366 (45%), Gaps = 77/366 (21%) Query: 13 SPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLE 72 S LAL Q+ + +L G V+LVP+VT GD ++++GG G+FV L ALL Sbjct: 36 SALALTQSGMIAAQLRERV-GCAVDLVPIVTAGDR-SPAEISQIGGTGVFVSALRDALLA 93 Query: 73 NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRR 132 D+AVHS+KD+P P GL L + RED RD VS + L AL G+ V T + RR Sbjct: 94 GEIDLAVHSLKDLPTATPPGLVLAAVPTREDTRDVLVSPSGRGLAALGPGARVATGAPRR 153 Query: 133 QCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEIS 192 QL + ++RGNV TRL K +GE DA++LA AGL RL + L PE+ Sbjct: 154 AAQLRALGLGFDVVAIRGNVDTRLKKAIDGEVDAVVLAYAGLARLDRLDAVTEILDPEVM 213 Query: 193 LPAVGQGAVGIE------------------------------------------------ 204 LPA GQGA+ +E Sbjct: 214 LPAPGQGALAVECAAEAGLRLAGPARALVAAGAGDHADGDRPGAEAGRDGRGRGPDVGRN 273 Query: 205 ---CRLD-----DSRTRELLAA-LNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID- 254 R D D ELL L+ +++ + AERA +E GC P+G+ A Sbjct: 274 SGQTRSDHGQPLDGGLAELLRFVLDDASSSVAIRAERAFLAGIEAGCTAPVGALAVAEPA 333 Query: 255 -----------------GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 G + LRA+V APDGS ++R + G+ D E +G LA++LL+ Sbjct: 334 PAAAVGTVAPAGDASPAGRLRLRAVVAAPDGSTVLRRDVTGSAVDPEALGQRLADDLLSA 393 Query: 298 GAREIL 303 GA ++ Sbjct: 394 GAHSLM 399 >UniRef50_Q1GP41 Porphobilinogen deaminase n=7 Tax=Sphingomonadales RepID=HEM3_SPHAL Length = 315 Score = 274 bits (702), Expect = 2e-72, Method: Composition-based stats. Identities = 134/306 (43%), Positives = 169/306 (55%), Gaps = 10/306 (3%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGL--VVELVPMVTRGDVILDTPLAKVGGKG 60 DN LRI TR SPLA+ QAH L+A+H +E+VPM GD I D LA+VGGK Sbjct: 8 DNPLRIGTRASPLAMAQAHMAAAALIAAHGLAMAALEIVPMTATGDRIQDRALAEVGGKA 67 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLD 117 L+ +EL+ AL D+AVHS+KDV L + ER DPRD V + Sbjct: 68 LWTRELDAALDAGTIDVAVHSLKDVETLRDARFFLGAMLERADPRDRLVVREGIAAQKIS 127 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177 LP G+ +GTSS RR Q+ RPDL LRGNV TRL+KL GE DA +LA AGL+RL Sbjct: 128 ELPHGARLGTSSPRRAAQVRRLRPDLDTVLLRGNVATRLAKLAAGEADATLLAAAGLERL 187 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 G+ I A E+ LPA QGA+GIECR DD+ T LLAA++H T V AERA+ Sbjct: 188 GM-HDIGAVQGTELLLPAASQGAIGIECRADDAATIALLAAIDHAPTHRAVAAERALLAV 246 Query: 238 LEGGCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 L G C+ P+ +YAE DG + L A + + DG+ + G +L LL Sbjct: 247 LGGDCRSPVAAYAEWQADGVLRLDAEIFSEDGADHVAGHVIVTDAGVVA---ALGHRLLA 303 Query: 297 NGAREI 302 I Sbjct: 304 EAPPSI 309 >UniRef50_Q83H95 Porphobilinogen deaminase n=2 Tax=Tropheryma whipplei RepID=Q83H95_TROW8 Length = 321 Score = 271 bits (693), Expect = 3e-71, Method: Composition-based stats. Identities = 109/331 (32%), Positives = 154/331 (46%), Gaps = 42/331 (12%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR S LA Q V+ + L + V + T D G FV Sbjct: 3 PLRIGTRSSLLATAQTAQVQKTMRDVFL-LDTQQVLIQTGSVRRRD---------GSFVA 52 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L ALLE D+AVHS+KD+P+ +G + + REDP D + +L LP+G+ Sbjct: 53 ALRTALLEGECDLAVHSLKDIPIAPHEGTLITAVLPREDPCDVLCARKDLTLTTLPSGAK 112 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGT+S RR+ Q+ RPDL + SLRGN+ RL LD DAI+L+ AGLKR+ E I Sbjct: 113 VGTASARRRAQILNFRPDLDVVSLRGNIDKRLIHLDT--LDAIVLSAAGLKRIDREDAIT 170 Query: 185 AALPPEISLPAVGQGAVGIE-CRL--DDSRTRELLA-ALNHHETALRVTAERAMNTRLEG 240 + A GQG++ IE CR DD + R + L++ + TAER + + L+ Sbjct: 171 ESFDIHDWPTAAGQGSLAIEVCRAQLDDPQNRVAVTYRLDNPMARVTTTAERGVLSLLQA 230 Query: 241 GCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRG--------------------ERRG 278 C PI +A D + L A V + DG Sbjct: 231 DCFSPIAVHAVYTANDKSLRLHAKVFSRDGKIFCESIRFARLVKQLTDTNQNHTKNSGSD 290 Query: 279 APQDAEQMGISLAE----ELLNNGAREILAE 305 +A ++ ++LA+ ELL+ AREIL + Sbjct: 291 DIGNALEVAMTLAKTVVDELLSKNAREILKQ 321 >UniRef50_UPI000038E213 porphobilinogen deaminase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E213 Length = 285 Score = 270 bits (690), Expect = 7e-71, Method: Composition-based stats. Identities = 91/266 (34%), Positives = 139/266 (52%), Gaps = 8/266 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 + I TR S LAL QA+ VKD L + G V + + GD + PL ++ G+FV Sbjct: 2 PVTIGTRNSKLALIQANSVKDALESR--GYEVNIKSYTSAGDSNKNIPLYRMSSTGVFVD 59 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 EL +L+ D+AVHS KD+P +GL + + R+D RD +S L+ + AGS+ Sbjct: 60 ELNERVLKGEIDLAVHSAKDIPSNIQKGLEITAVTGRDDFRDVLISR--TPLEEMTAGSV 117 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSS+RR Q P++ + +RGN+ TR+SK +Y II+A+A KR+ L+ Sbjct: 118 IGTSSMRRIRQAMTVNPEITVSDIRGNIDTRISKYTEKKYTGIIIAMAAYKRMKLDIE-H 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L E LPA QG + I + + + + +N ET + ER + T L GC + Sbjct: 177 FILSEEQFLPAPNQGIIAIVGKSNSPASI-ISGEINDRETYRDMKNERFIATSLNLGCSM 235 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQ 270 P+G ++ DG+I R D + Sbjct: 236 PVGILSK--DGKIKTRFYSLDSDEHR 259 >UniRef50_A9V9E0 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V9E0_MONBE Length = 643 Score = 268 bits (685), Expect = 2e-70, Method: Composition-based stats. Identities = 99/206 (48%), Positives = 124/206 (60%), Gaps = 6/206 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LA+WQ +V ++L +HPG+ +VP+ T GD L L K G+F Sbjct: 417 IRIGTRSSVLAMWQTRWVVERLTRAHPGVRFSVVPLSTVGDANLTLDLNKFSTTGIFTDA 476 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS----LDALPA 121 L ALL DI VHS+KD+P G L I REDPRD V ++ S L LPA Sbjct: 477 LVRALLAQEVDILVHSLKDLPSTISPGTQLAAIGPREDPRDVVVFHHRHSEIKDLAQLPA 536 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN--GEYDAIILAVAGLKRLGL 179 G++VGTSS RR+ QLA P L +RGNV TRL KLD+ YDA+ LA AGL RLGL Sbjct: 537 GAVVGTSSTRRRAQLAAAYPQLRFAPVRGNVMTRLRKLDDPANGYDALCLAAAGLIRLGL 596 Query: 180 ESRIRAALPPEISLPAVGQGAVGIEC 205 E+RI LP +S A+GQGA+GI+ Sbjct: 597 EARIGQFLPLTVSRHAIGQGALGIQV 622 >UniRef50_UPI0001C31A39 porphobilinogen deaminase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31A39 Length = 314 Score = 262 bits (671), Expect = 1e-68, Method: Composition-based stats. Identities = 132/292 (45%), Positives = 169/292 (57%), Gaps = 13/292 (4%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +VLRI TR S LAL QA +V L G VE++P+ T GD +G K +V Sbjct: 2 SVLRIGTRASALALVQAEHVASLLRDG--GAQVEVIPITTSGDRGR-----LLGDKSRWV 54 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE ALL + D+AVHS KDVP E P G L + R D RDA SL+ LP G+ Sbjct: 55 KELEAALLADEVDVAVHSAKDVPAELPDGFVLAGVPARADARDALCG--AASLEQLPDGA 112 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +VGTSSLRR +L RPDL + +LRGNV TRL KL +G+ AI+LAVAGL+RL + I Sbjct: 113 VVGTSSLRRAAELRALRPDLGVVALRGNVDTRLRKLADGQAAAIVLAVAGLERLDRGAAI 172 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 A L + +PA GQGA+ +E R DD R R AA+ + A + AERA+ RL C Sbjct: 173 GAVL--DQLVPAPGQGALALETRADDDRARAAAAAITDADAAACLAAERALVRRLGATCH 230 Query: 244 VPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAPQ-DAEQMGISLAEE 293 P+G++A DG + LR+ VG PDGS +R E A D E G++ Sbjct: 231 TPLGAHAVRTADGGLRLRSFVGLPDGSAWLRDELSAAAGIDPETFGVAAGTR 282 >UniRef50_Q04X38 Bifunctional porphobilinogen deaminase/uroporphyrinogen synthase n=4 Tax=Leptospira RepID=Q04X38_LEPBL Length = 542 Score = 262 bits (670), Expect = 1e-68, Method: Composition-based stats. Identities = 89/279 (31%), Positives = 127/279 (45%), Gaps = 32/279 (11%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + VL+IA+R+S LA Q + V D L P + +EL GD+ L TPL K+G +G+ Sbjct: 1 MSRVLKIASRKSALAKLQTYLVLDALKKKFPNIQIELHFREASGDLDLQTPLWKMGTRGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F ++L L+E + D+ +HS KD+ +E G +V + +R D RD + P+ Sbjct: 61 FTQDLTKDLVEKKVDLVIHSWKDLDLEGHSGTTIVGVLDRADQRDVLLWKKSSLSKNFPS 120 Query: 122 GSIVGTSSLRRQCQLAERRPD----------LIIRSLRGNVGTRLSKLDNGEYDAIILAV 171 + TSS RR+ L + + LI +RGN+ TR+ K N + D ++LA Sbjct: 121 ELKIQTSSPRREYNLKKFLNNSLPSRYKNSSLIFLPVRGNIQTRIRKWRNSDSDGLVLAK 180 Query: 172 AGLKRL----------------------GLESRIRAALPPEISLPAVGQGAVGIECRLDD 209 A L RL LE I LP +S A QGA+ E R DD Sbjct: 181 AALDRLLSEDFLNSNELEYQEIRKFLKEILEESIFQVLPLSLSPSAPAQGAIAAEVRTDD 240 Query: 210 SRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGS 248 + AL+ E V ER R GGC IG Sbjct: 241 EWALGFVRALSKPEVVSAVEEERNTLKRFGGGCHQKIGV 279 >UniRef50_B0SF66 Bifunctional porphobilinogen deaminase/uroporphyrinogen synthase n=2 Tax=Leptospira biflexa serovar Patoc RepID=B0SF66_LEPBA Length = 511 Score = 261 bits (668), Expect = 2e-68, Method: Composition-based stats. Identities = 88/314 (28%), Positives = 136/314 (43%), Gaps = 37/314 (11%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + ++I R S L+ Q H V + L + L E + + GD L TPL + GG+G+ Sbjct: 1 MSETIKIGGRSSLLSRIQIHTVTNALKEKNKDLNFETIFRESSGDKDLTTPLWQFGGQGI 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F K+L+ LL ++ DI +HS KD+ ++ + L+ + RED RD + ++ LP Sbjct: 61 FTKDLQEDLLNHKVDIVIHSYKDMDLKERKETTLIPVLPREDVRDVLLFKKNKWIN-LPN 119 Query: 122 GSIVGTSSLRRQC----QLAERRPD------LIIRSLRGNVGTRLSKLDNGEYDAIILAV 171 + TSS RR+ L P + I S+RGN+ TRL K + E I++A Sbjct: 120 EITILTSSPRREYHIKEFLRNYFPTPINNFEIKIESVRGNIQTRLRKYLDHESGGILVAK 179 Query: 172 AGLKRL----------------------GLESRIRAALPPEISLPAVGQGAVGIECRLDD 209 A L R+ + + LP I A QGA+ E R +D Sbjct: 180 AALDRILNFQDPDQLLPELKEIQQLIKDTMNVSLFMVLPSSIFPSAPAQGALCAEIRKED 239 Query: 210 SRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYA--ELIDGEIWLRALVGAPD 267 LL+ ++ ET L ER + +R GGC IG ++R + D Sbjct: 240 KHLETLLSKISDSETNLTTNEEREILSRYGGGCHQKIGVTVLHREYGKVCFIRGI--TED 297 Query: 268 GSQIIRGERRGAPQ 281 G + E +P Sbjct: 298 GQILQTKELSESPN 311 >UniRef50_A7BMK1 Porphobilinogen deaminase n=1 Tax=Beggiatoa sp. SS RepID=A7BMK1_9GAMM Length = 211 Score = 261 bits (668), Expect = 2e-68, Method: Composition-based stats. Identities = 123/209 (58%), Positives = 148/209 (70%), Gaps = 1/209 (0%) Query: 101 REDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD 160 RE+P DAFVSN Y +L ALP G+IVGTSSLRRQ QL RPDL IRSLRGNVGTRLSKLD Sbjct: 3 REEPFDAFVSNTYATLAALPEGAIVGTSSLRRQSQLLAHRPDLQIRSLRGNVGTRLSKLD 62 Query: 161 NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALN 220 NG+YDAI+LA GLKRLGL RIR + I LPA+GQGA+GIECR DD TR+ + LN Sbjct: 63 NGDYDAIVLAAVGLKRLGLVERIREIIDSTIMLPAIGQGAIGIECRQDDLETRQHIDNLN 122 Query: 221 HHETALRVTAERAMNTRLEGGCQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGA 279 +T V AERA+N LEGGCQVPI YAE+ + +R LVG +G I+R +GA Sbjct: 123 DPDTQDCVIAERALNESLEGGCQVPIAGYAEIQSSENLTMRGLVGDIEGQHILRHNLQGA 182 Query: 280 PQDAEQMGISLAEELLNNGAREILAEVYN 308 A ++G SLA+ LL GA +IL ++ + Sbjct: 183 RHLAAELGKSLAKVLLTQGAAQILEKLKD 211 >UniRef50_A5K0J5 Porphobilinogen deaminase, putative n=1 Tax=Plasmodium vivax RepID=A5K0J5_PLAVI Length = 341 Score = 258 bits (661), Expect = 1e-67, Method: Composition-based stats. Identities = 91/337 (27%), Positives = 147/337 (43%), Gaps = 69/337 (20%) Query: 45 GDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDP 104 GD ILD + GGKG+F KEL+ L++ I VHS+KDVP+E P+ + L +R+ Sbjct: 2 GDHILDKKVGLFGGKGIFTKELDEQLIKKNVHICVHSLKDVPMELPEHVQLSCFLKRDTI 61 Query: 105 RDAFVSNNYDSLDALPAGS---------------------------------------IV 125 DAF+S Y +L+ + + Sbjct: 62 NDAFLSVKYATLEDMNKRKMANKVEEESDQEKGTIQQMTNQGLKRDNCEGDKCTNFIPTI 121 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR Q+ ++ ++++RGN+ TR++KL NG+YDAII+A GL+RL + +R Sbjct: 122 GTSSLRRSSQIKYTYKNVAVKNVRGNINTRIAKLCNGQYDAIIIAKCGLERLLTKKVVRN 181 Query: 186 AL------PPEISL------------------------PAVGQGAVGIECRLDDSRTREL 215 + PPE L PA+ QG + + +D T + Sbjct: 182 IIRGKGKVPPEKFLLNHNDMETNLRLLRIQQINRRTIYPALCQGIIAVTSHKNDVDTSNI 241 Query: 216 LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE 275 L +N + + ER+ ++EG C +PIG YA+++ GEI A++ G + Sbjct: 242 LKNINDEKAQIMANVERSFLYQIEGNCMMPIGGYAQIVGGEIVFNAVINDTHGREKYHVR 301 Query: 276 RRGAPQDAEQMGISLAEELLNNGAREILAEVYNGDAP 312 G Q+ + A ++ ++ A Sbjct: 302 EVGTVQNCNNIAAMAATKMKEKIGTHRFNKIKEEAAQ 338 >UniRef50_B1ZV87 Porphobilinogen deaminase n=2 Tax=Opitutaceae RepID=B1ZV87_OPITP Length = 284 Score = 254 bits (649), Expect = 4e-66, Method: Composition-based stats. Identities = 94/260 (36%), Positives = 126/260 (48%), Gaps = 15/260 (5%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L +ATR+SPLAL Q V L A G+ EL+ +VT GD + L + GGKGLF Sbjct: 2 KKLILATRKSPLALRQTEMVAAHLEAR-LGVQTELLKLVTTGDRQTEWSLEQKGGKGLFT 60 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 ELE AL AD+AVHS KD+P + L + R D RD V + A Sbjct: 61 SELENALRRGEADLAVHSTKDLPGDMAAELAVAGYLPRADARDVLVLRAG-----VAAPK 115 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESR 182 + T S RR+ Q+A+ P + +RGNV TRL K+ G D +LA AGL RLG+ + Sbjct: 116 SLATGSPRRRLQIAKLYPGVTFTEIRGNVDTRLKKIGELGVADGTVLASAGLNRLGIGNW 175 Query: 183 IRAALP---PEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 +PAVGQGA+ ++CR D+ A + T V ERA L Sbjct: 176 PGVEFHALGFNDMVPAVGQGAIAVQCRAADAA---RFAPVFDAATKRAVDVERAFQAALG 232 Query: 240 GGCQVPIGSYAELIDGEIWL 259 GCQ G++ + + Sbjct: 233 VGCQTAFGAH--VAGDTLHF 250 >UniRef50_Q86ET2 Clone ZZD1450 mRNA sequence n=3 Tax=Schistosoma japonicum RepID=Q86ET2_SCHJA Length = 277 Score = 243 bits (620), Expect = 7e-63, Method: Composition-based stats. Identities = 100/329 (30%), Positives = 137/329 (41%), Gaps = 75/329 (22%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + +R+ +R+S LAL Q L P ++ E+V + T GD ILD PL+K+G K L Sbjct: 6 SQHAVRVGSRRSNLALLQTEMAISLLKVQKPHIMFEVVEIATVGDEILDVPLSKIGDKSL 65 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS---NNYDSLDA 118 F KELE +LL D+ VHS+KDVP P GL L + R P D + N L Sbjct: 66 FTKELEKSLLVGEVDLVVHSLKDVPSVLPTGLVLGCVFGRSSPEDVVLMAPHNRGMKLSD 125 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG--------------EY 164 LP G+ VGTSS+RR L + P L S+RGN+ TRL+KLD Y Sbjct: 126 LPVGATVGTSSIRRVATLIRKYPHLKFISIRGNLNTRLAKLDTPSNLQKQCCTGNQSLSY 185 Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224 DA+ILA AG++R+G RI L DS L + Sbjct: 186 DALILAKAGVERMGWVDRIDQVLS--------------------DSFYANELKGALDASS 225 Query: 225 ALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAE 284 +G LR + A+ Sbjct: 226 VF-------------------MGVAVTPSSEVSRLRMAI-------------------AQ 247 Query: 285 QMGISLAEELLNNGAREILAEVYNGDAPA 313 +G +A+ LL +GA EIL E+ + + Sbjct: 248 SLGCIVAKYLLLSGAGEILHEIRSQSTES 276 >UniRef50_C0EAN0 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum DSM 5476 RepID=C0EAN0_9CLOT Length = 292 Score = 237 bits (605), Expect = 4e-61, Method: Composition-based stats. Identities = 87/293 (29%), Positives = 127/293 (43%), Gaps = 16/293 (5%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 + I Q+ L+ A ++ L + HP L ELVP+ G T L Sbjct: 13 EKIHIGCAQNELSRNFADHLAQCLHSYHPELTAELVPIKNTGADEEPT---------LVA 63 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 + LE AL++ R D+AV+ D+P+E L +V I RED RDA V P S Sbjct: 64 RRLEQALIDCRVDLAVYHALDLPLELHPELPIVAISSREDVRDALVFPQG---KQQPDFS 120 Query: 124 I-VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 +G +S R+Q QL PD I + G V +L++LD GEY A++L A L GL+ R Sbjct: 121 KPIGCTSRRQQVQLHRVFPDCITAPVGGTVAEQLARLDQGEYGALVLPAAQLGWFGLQQR 180 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 + E +PA G A+ ++ R LL + ++ V ER LE Sbjct: 181 VGQLFCVEELVPAAGHAAIAVQARE--EFDAGLLECFHSWDSWDAVFCEREFARALEEE- 237 Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295 PI +AE+ + + G +DA ++G LA EL Sbjct: 238 PGPIAVHAEVKGETLSVVGFYADEAEGIYRMSSMSGDRKDAGRLGFELAAELK 290 >UniRef50_Q6MHU0 Hydroxymethylbilane synthase n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MHU0_BDEBA Length = 502 Score = 235 bits (601), Expect = 1e-60, Method: Composition-based stats. Identities = 82/290 (28%), Positives = 123/290 (42%), Gaps = 37/290 (12%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LRI+ R+S LA QA+ V D L +P + ++ + GD L PL K+ KG+F ++ Sbjct: 3 LRISARKSDLARLQAYMVGDALKEKNPQIEIDYRFRESLGDKNLTDPLWKIPEKGVFTED 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-----DSLDALP 120 LL + D+ VHS KD+P E + R D RD + + L Sbjct: 63 FFGELLRDETDLVVHSWKDLPTEHKSETVIAATLPRADQRDLLLVKKSHFDKIKTSKTL- 121 Query: 121 AGSIVGTSSLRRQCQL----AERRP----DLIIRSLRGNVGTRLSKL-DNGEYDAIILAV 171 V +SS RR+ L E P D+ S+RGN+ TR+ KL ++ E D +I+A Sbjct: 122 ---KVFSSSPRREYNLTGFFKEHLPFGLQDVKFESVRGNMLTRVRKLIESPETDGLIVAK 178 Query: 172 AGLKRLG-----------------LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRE 214 A RL LP ++ A QGA+ +E ++ Sbjct: 179 AAFDRLFSATLPEFLEGQQQLRQYFNELNWVVLPLSVNPNAAAQGALAVEVLKSRQDLQD 238 Query: 215 LLAALNHHETALRVTAERAMNTRLEGGCQVPIG--SYAELIDGEIWLRAL 262 LL +++H +T ER + + GGC IG A L+ L Sbjct: 239 LLQSIHHADTFHCSQKERDVLSSFGGGCHQKIGVAVLARPYGQITLLKGL 288 >UniRef50_Q4E9D5 Porphobilinogen deaminase (Fragment) n=1 Tax=Wolbachia endosymbiont of Drosophila ananassae RepID=Q4E9D5_9RICK Length = 199 Score = 233 bits (594), Expect = 8e-60, Method: Composition-based stats. Identities = 81/202 (40%), Positives = 121/202 (59%), Gaps = 6/202 (2%) Query: 97 TICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRL 156 + ER P DAF+S+ ++SL++LP + + TS++RR+ QL RPDL I LRGNV TRL Sbjct: 1 CVLERLSPCDAFISHKHNSLESLPQQATIATSAIRRKVQLLNFRPDLNIVPLRGNVTTRL 60 Query: 157 SKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELL 216 N +D IILA AGL RL I LPP++ L AVGQGA+ I+CR +D + +LL Sbjct: 61 ---QNQSFDGIILAEAGLIRLEKHHLITEVLPPKVMLSAVGQGAICIQCRRNDVKIIDLL 117 Query: 217 AALNHHETALRVTAERAMNTRLEGGCQVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGE 275 +N++ + + V +ER+ + G C P+ + AE + + ++LR ++ DG I E Sbjct: 118 EKINNNMSFIGVKSERSFMKTVNGSCFTPLAALAEYVSENMLYLRCMLA--DGKNIYFTE 175 Query: 276 RRGAPQDAEQMGISLAEELLNN 297 R +DAE+MG+ EL + Sbjct: 176 RTSFIEDAEKMGMDAGLELKSK 197 >UniRef50_B6YQR9 Hydroxymethylbilane synthase/uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YQR9_AZOPC Length = 682 Score = 225 bits (574), Expect = 2e-57, Method: Composition-based stats. Identities = 80/226 (35%), Positives = 119/226 (52%), Gaps = 18/226 (7%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG- 60 LR+ +R SPL+L Q V + P + +L+ + + GD L + Sbjct: 7 SKGNLRVISRNSPLSLLQVKEV----FSFFPNIDYQLITIESFGDKNKHVALFDISNVSS 62 Query: 61 ----------LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS 110 F +EL+ AL+ N+ADIAVHS KD+P P L L + + D D+ +S Sbjct: 63 FFLEEESISDFFTRELDEALIYNKADIAVHSAKDLPYPLPYDLELFALFQAMDKSDSLIS 122 Query: 111 NNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILA 170 N +L+ LP + VGTSS +R+ +L + RPDL + S+RGN+ R++K+DNG DA+I+A Sbjct: 123 RNNLTLEQLPPRARVGTSSQKRKTELLKIRPDLEVVSIRGNIEERIAKMDNGFIDALIVA 182 Query: 171 VAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELL 216 L RLG+E+RI LP E QG + I R +D + L Sbjct: 183 TCALIRLGMEARIACILPFETH---SLQGNLAIVGRKNDKNVKNLF 225 >UniRef50_Q6MEK3 Putative Porphobilinogen deaminase n=2 Tax=Parachlamydiaceae RepID=Q6MEK3_PARUW Length = 233 Score = 224 bits (571), Expect = 3e-57, Method: Composition-based stats. Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 3/218 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 + + R SPL+ Q + L + +P + + T GD+ T L + F KE Sbjct: 18 ISVGARSSPLSRAQVQEILKALRSFYPSIEFTISYFDTIGDLDQKTSLRDLDKTNFFTKE 77 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 ++ A+L+ + I +HS KD+P P GL L+ + + D D V + ++L LP S + Sbjct: 78 IDEAILQKKCQIGIHSAKDLPDPIPDGLQLICLTKGVDCSDVLVLRDGETLQTLPPHSRI 137 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 TSS+RR+ + R D I LRG + RL+ L+ + D +++A A L RLGL R Sbjct: 138 ATSSIRRENIVKLLRNDFIFLDLRGTIHQRLALLEKKQADGVVVAEAALIRLGLTHLNRI 197 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHE 223 LP GQG + I R DD++ + L A L+ + Sbjct: 198 RLPGTTV---EGQGQLAIIARKDDAKMQTLFACLDVRK 232 >UniRef50_B4UXX3 Porphobilinogen deaminase 2 (Fragment) n=1 Tax=Streptomyces sp. Mg1 RepID=B4UXX3_9ACTO Length = 231 Score = 223 bits (568), Expect = 8e-57, Method: Composition-based stats. Identities = 88/231 (38%), Positives = 120/231 (51%), Gaps = 13/231 (5%) Query: 1 MLDN-----VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAK 55 M+ + +R+ TR SP+AL Q D A +P +V+++V +V+ GD PL+ Sbjct: 1 MMTSSTDLTTVRLGTRPSPMALEQTGRFADVFRARYPQVVLDIVEIVSEGDRHRG-PLST 59 Query: 56 VGGKGLFVKELEVALLENRADIAVHSMKDVPVEFP--QGLGLVTICEREDPRDAFVSNNY 113 +GGKG F + + LL+ R + KDVP G+ + + RED RDA V Sbjct: 60 IGGKGAFTRNADRYLLDGRVQATIACAKDVPGPHDRSPGIVIAAVLPREDTRDALVLPTG 119 Query: 114 D---SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDA--II 168 +L LP G+ VGTS+ RR L P L+ +RGN +RL LD G A +I Sbjct: 120 HPVTTLAELPPGTRVGTSAPRRSALLKALHPTLVQVPIRGNADSRLRALDAGRLGADVMI 179 Query: 169 LAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAAL 219 A+AGL+RLG E R L P + LPA G G V +E R DD T LLA L Sbjct: 180 AALAGLRRLGHEDRASEILDPAVWLPAAGAGTVIVEHRSDDPATGWLLAPL 230 >UniRef50_A8I2X7 Porphobilinogen deaminase n=1 Tax=Chlamydomonas reinhardtii RepID=A8I2X7_CHLRE Length = 380 Score = 218 bits (557), Expect = 1e-55, Method: Composition-based stats. Identities = 102/319 (31%), Positives = 137/319 (42%), Gaps = 36/319 (11%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMA----SHPGLVVELVPMVTRGDVILDTPLAKVGG 58 L IATR S LA Q V+ L+A L + + + +RGD L +G Sbjct: 60 QRPLVIATRPSKLAKEQTRQVQQLLLAAAQLKDEQLQLSTLELASRGDTTQGVSLRSLG- 118 Query: 59 KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118 G F +EL+ A+L AD++VHS+KD P GL L R DPRD ++ SL Sbjct: 119 SGAFTEELDQAVLSGAADMSVHSLKDCPAALAPGLLLAACLPRADPRDVLIAPEATSLGE 178 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 L GS VGTSS RR Q+ P L + LRGNV +RL ++ + + A +LA AGLKRLG Sbjct: 179 LVPGSRVGTSSSRRAAQIKHSFPHLQVVQLRGNVDSRLGRIRSRDIGATVLAAAGLKRLG 238 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR- 237 + + GAVG+ CR DD LL A++H TAL V AERA Sbjct: 239 VMNSDEGD--------TTATGAVGVVCRADDEWVVGLLDAISHRGTALEVAAERACLAAL 290 Query: 238 --------------LEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER----RGA 279 + C + + L LV +G ++ R Sbjct: 291 LGGGGACQRSAFPDIAWACHTRH----DPDSNTMDLDCLVADLEGKELFRYTEFYRPVID 346 Query: 280 PQDAEQMGISLAEELLNNG 298 DA +G L Sbjct: 347 EVDAVSLGSLYGSLLRMMA 365 >UniRef50_Q6Q923 Predicted porphobilinogen deaminase n=2 Tax=environmental samples RepID=Q6Q923_9GAMM Length = 291 Score = 210 bits (535), Expect = 5e-53, Method: Composition-based stats. Identities = 82/252 (32%), Positives = 115/252 (45%), Gaps = 17/252 (6%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGL-VVELVPMVTRGDVILDTPLAKVGGKGLFV 63 ++IA+R S LAL Q K G+ +++ + T GD I + K FV Sbjct: 2 TIKIASRSSKLALAQVEEFVKKF-----GISDYKIIKVKTEGD-IKSANGETLFDKAHFV 55 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 +++ LL ADIAVHS KD P GL L + +D + D ++ Sbjct: 56 SDVQKCLLNGEADIAVHSAKDTPAGETTGL-LRYFLPSQSNQDVLIFREEDKFNS---EM 111 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +GTSSLRRQ Q + I +L GNV TRL KL GEYD IILA AGL RL L + + Sbjct: 112 KLGTSSLRRQLQAKHHLNAINIVNLSGNVDTRLEKLSQGEYDCIILAKAGLARLKLLNEL 171 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSR--TRELLAALN--HHETALRVTAERAMNTRLE 239 + + A GQG + IE D S LL ++ ++ ER++ + Sbjct: 172 QYEVM--DWSTASGQGFLCIEVLNDPSADIYNFLLKSIREIDLNLGKNISTERSILEAIN 229 Query: 240 GGCQVPIGSYAE 251 GC I + Sbjct: 230 AGCNSAISIQTQ 241 >UniRef50_Q9PK95 Probable porphobilinogen deaminase n=13 Tax=Chlamydiaceae RepID=HEM3_CHLMU Length = 242 Score = 207 bits (528), Expect = 3e-52, Method: Composition-based stats. Identities = 69/197 (35%), Positives = 105/197 (53%), Gaps = 3/197 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LR+A+R+SPLA+ QAH +L P L +++ T+GD+ TPL V G F Sbjct: 20 PLRLASRKSPLAVLQAHECLRRLQTFFPRLWGQVITETTQGDLDQHTPLHSVENTGFFTD 79 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 +++ + + D+A+HS KD+P E P+ + I DPRD V L P+ Sbjct: 80 DIDFLVQSGKCDLAIHSAKDLP-EKPKARVI-AITASIDPRDILVFQEKYLLQPFPSRLR 137 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +G SS RR+ ++ P +I +RG + TRL+ LD ++DAI++A A + RLGL Sbjct: 138 IGCSSDRRRALISSLYPSAVITDIRGTIQTRLALLDQQKFDAIVMANAAVSRLGLRLPCT 197 Query: 185 AALPPEISLPAVGQGAV 201 LPP P G+ A+ Sbjct: 198 VVLPPPYH-PFQGRLAI 213 >UniRef50_D0RNS6 Putative porphobilinogen deaminase (Pbg)(Hydroxymethylbilane synthase) (Hmbs) (Pre-uroporphyrinogen synthase) n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RNS6_9RICK Length = 492 Score = 203 bits (517), Expect = 6e-51, Method: Composition-based stats. Identities = 79/281 (28%), Positives = 120/281 (42%), Gaps = 28/281 (9%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + L I +R S LA Q VK +L + + T+GD K G G+ Sbjct: 1 MSLSLIIGSRASFLAKIQTFIVKQELKKKIKNIKITTKYHSTKGDKNQGHMPWKNLGYGI 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F L L+ + VHS KD+PV + + R+DPRD + Sbjct: 61 FTTSLTNELINKNFNCVVHSYKDLPVL--KSKTDYYVITRDDPRDVLLVKKKCLNK---K 115 Query: 122 GSIVGTSSLRRQCQLAERRP-----DLIIRSLRGNVGTRLSK-LDNGEYDAIILAVAGLK 175 IVGTSS RR+ + + + D+ +++RGNV TRL K + +YDA+ +A A + Sbjct: 116 KFIVGTSSPRRKSSVKDLKDLTGIKDIKTKTIRGNVTTRLLKVISKNQYDAVFMAKAAID 175 Query: 176 R----------------LGLESRIR-AALPPEISLPAVGQGAVGIECRLDDSRTRELLAA 218 R L L + + LP I A QGA+ +E +D +T+ L Sbjct: 176 RIFKYGNKVDKVETKKFLNLFKKFKPFILPLSIFPTAASQGAIAVEYLKNDKKTKSTLNK 235 Query: 219 LNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWL 259 +N +T ER++ + GGC + IG E I +L Sbjct: 236 INCKKTLSICNQERSLLKKYGGGCGLDIGITIEEIKNNNFL 276 >UniRef50_C5LJF7 Porphobilinogen deaminase, putative n=5 Tax=Perkinsus marinus ATCC 50983 RepID=C5LJF7_9ALVE Length = 556 Score = 200 bits (510), Expect = 4e-50, Method: Composition-based stats. Identities = 79/298 (26%), Positives = 115/298 (38%), Gaps = 40/298 (13%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 +VL I +R+S LA Q + D L G+ VE GD L PL K+ G+F Sbjct: 7 PSVLHIGSRRSDLARLQTLMIADLLQDEM-GVKVECHYREAPGDTNLKDPLWKMPETGVF 65 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 L L+ D+ VHS KD+P+ G +V R DPRD + + G Sbjct: 66 TSFLRDGLMNGAFDLVVHSWKDLPLAEESGTTVVATLPRADPRDLLLIRRDAIEEMTSEG 125 Query: 123 SI--VGTSSLRRQCQLAERRP-------DLIIRSLRGNVGTRLSKLDNGEY--------- 164 V +SS RRQ L + R +RGN+ TR+ KL + Sbjct: 126 GKLIVLSSSPRRQFNLTPFLESVVPGVTSVQFRDVRGNIQTRMKKLMDPTIHDESLGCRP 185 Query: 165 DAIILAVAGLKRL----------------GLESRIRA-ALPPEISLPAVGQGAVGIECRL 207 +++A A + R G S R LP + A QGA+GIE Sbjct: 186 HGLVVAKAAVDRFIRSTREEFKESRQLVQGYISECRCMVLPLSANPTAAAQGALGIEVST 245 Query: 208 --DDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGS--YAELIDGEIWLRA 261 + R+++ +LN T + E+ + GGC IG ++L Sbjct: 246 APEKEHVRKIVRSLNDRSTFDAASKEKELLNSYGGGCHQKIGCTILPRQYGDVLFLCG 303 >UniRef50_Q9HMY5 Probable porphobilinogen deaminase n=2 Tax=Halobacterium salinarum RepID=HEM3_HALSA Length = 396 Score = 196 bits (499), Expect = 1e-48, Method: Composition-based stats. Identities = 72/165 (43%), Positives = 96/165 (58%), Gaps = 2/165 (1%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M +R+ATR S LAL QA V D L VELV + T GD + D ++ +G G Sbjct: 1 MSSQQIRLATRGSDLALRQAGEVVDTLEDRR--HDVELVEVETEGDRVTDALISDLGKTG 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 FV+ L+ ++E D AVHSMKDVP E P+ L + + RE+P D V+ + L+ LP Sbjct: 59 AFVRALDQEVMEGTVDAAVHSMKDVPTEVPEDLVVAAVPHRENPADVLVTPDGTDLEDLP 118 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYD 165 AGS+VGT+SLRR Q+ RP L + +RGNVGTR+ KL Sbjct: 119 AGSVVGTASLRRGAQVQAHRPGLDVEPIRGNVGTRVEKLLAPALH 163 Score = 138 bits (348), Expect = 3e-31, Method: Composition-based stats. Identities = 48/146 (32%), Positives = 70/146 (47%), Gaps = 1/146 (0%) Query: 163 EYDAIILAVAGLKRLGLESRIR-AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNH 221 EYDA+++A GL+R GL + L +PA GQGA+ + R D L AL H Sbjct: 248 EYDALVMARVGLERTGLLHHVGIEELSTGTHVPATGQGALCVTARRDSDVVDTLRDALEH 307 Query: 222 HETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ 281 T + VTAER + L GGC PIG +A + I V + DGS+ + R + Sbjct: 308 VRTRVEVTAERVVLEELGGGCIAPIGVHALVQGDTIRTAVQVFSQDGSEQVGETRELDAE 367 Query: 282 DAEQMGISLAEELLNNGAREILAEVY 307 LA +L + GA +++ + Sbjct: 368 QYATDARELAADLRDRGAADLIEDAR 393 >UniRef50_Q18ES3 Hydroxymethylbilane synthase (Porphobilinogen deaminase) n=9 Tax=Halobacteriaceae RepID=Q18ES3_HALWD Length = 394 Score = 181 bits (461), Expect = 2e-44, Method: Composition-based stats. Identities = 66/157 (42%), Positives = 95/157 (60%), Gaps = 4/157 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 L +ATR S LAL QA V++ L V+L+ + TRGD I D + ++G G FV+ Sbjct: 10 TLTLATRGSDLALKQATSVQEALTDER--YEVDLIEVETRGDQIQDELIHQLGKTGAFVR 67 Query: 65 ELEVALLE--NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 L+ +L+ AD AVHSMKD+P + P L + I +R P D ++ + L LP+G Sbjct: 68 ALDKKVLDPTAEADAAVHSMKDMPTDSPDDLVVAGIPQRAPPGDLLITTDGQRLSDLPSG 127 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL 159 + +GTSSLRRQ QL ++R D+ + LRGN+ TR+ KL Sbjct: 128 ATIGTSSLRRQAQLLDQRTDITVEPLRGNIDTRIEKL 164 Score = 137 bits (345), Expect = 6e-31, Method: Composition-based stats. Identities = 52/153 (33%), Positives = 76/153 (49%), Gaps = 1/153 (0%) Query: 156 LSKLDNGEYDAIILAVAGLKRLGLESRIRAA-LPPEISLPAVGQGAVGIECRLDDSRTRE 214 L + EYDAI+LA AGL+R GL I L +PA GQGA+ I + + + T + Sbjct: 228 LERSVETEYDAIVLAEAGLQRSGLIHHIEYVQLDTTTFVPAPGQGAIAITTQGEANATAQ 287 Query: 215 LLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRG 274 + A++H T + T ER + L GGC PIG +A L + + A V A DG++ + G Sbjct: 288 IREAIDHPRTRVETTVERTVLAELGGGCIAPIGVHATLQGEYVHVAAQVFASDGTETVDG 347 Query: 275 ERRGAPQDAEQMGISLAEELLNNGAREILAEVY 307 R A +L + GA E++A Sbjct: 348 SRNLPVDAHADAAAQFANKLADRGADELIAAAR 380 >UniRef50_UPI000155526F PREDICTED: similar to hydroxymethylbilane synthase n=1 Tax=Ornithorhynchus anatinus RepID=UPI000155526F Length = 218 Score = 166 bits (420), Expect = 1e-39, Method: Composition-based stats. Identities = 60/130 (46%), Positives = 78/130 (60%), Gaps = 9/130 (6%) Query: 75 ADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALPAGSIVGTSSLR 131 D+ VHS+KD+P P G + +C+RE P DA V + +L LP S+VGTSSLR Sbjct: 90 VDLVVHSLKDLPTVLPPGFTIGAVCKRESPYDAVVFHPKHVGKTLATLPEKSVVGTSSLR 149 Query: 132 RQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESRIRAALPPE 190 R QL + P L +S+RGN+ TRL KLD E+ AIILA AGL+RLG +SR+ Sbjct: 150 RAAQLQRKFPHLEFKSIRGNLNTRLRKLDELQEFSAIILAAAGLQRLGWQSRLGQV---- 205 Query: 191 ISLPAV-GQG 199 PA G+G Sbjct: 206 RVAPAPRGRG 215 >UniRef50_B0KCR7 Porphobilinogen deaminase n=3 Tax=Thermoanaerobacter RepID=B0KCR7_THEP3 Length = 168 Score = 161 bits (408), Expect = 3e-38, Method: Composition-based stats. Identities = 48/164 (29%), Positives = 82/164 (50%), Gaps = 7/164 (4%) Query: 136 LAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPA 195 + D+ I +RGNV TRL K++ D I+L+ AGL RLGLES I PP++ +PA Sbjct: 4 IQALMSDIQIVPIRGNVRTRLKKMEELNLDGIVLSAAGLHRLGLESIITEYFPPDVVVPA 63 Query: 196 VGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAEL-- 252 QG + +E D+ +E + + T + ER + C+ P G+YA+ Sbjct: 64 PCQGILAVEIAESFDNIFQEFYSYIVDRRTFFEASVERELLKAFGVNCRQPFGAYAQYRK 123 Query: 253 --IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 + +I ++ + D ++++ E G ++ ++M L EE Sbjct: 124 EKDEEKINIKVVYQKED--KLLKSEVTGLIEETDKMIEKLIEEF 165 >UniRef50_C0DZX9 Putative uncharacterized protein n=1 Tax=Corynebacterium matruchotii ATCC 33806 RepID=C0DZX9_9CORY Length = 152 Score = 154 bits (391), Expect = 3e-36, Method: Composition-based stats. Identities = 54/150 (36%), Positives = 79/150 (52%), Gaps = 1/150 (0%) Query: 156 LSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTREL 215 ++K+ +GE DA++LA AGL R+ P LPA QGA+ +ECR DD+ T Sbjct: 1 MAKVHDGELDAVVLAYAGLSRVHRADEATEVFDPLEFLPAPAQGALAVECRADDADTIAA 60 Query: 216 LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEI-WLRALVGAPDGSQIIRG 274 + + + ER + RLE GC P+ +YA + I L A V A DGS +R Sbjct: 61 ITTIADSKAYACAHTERVVLARLEAGCTAPVAAYATVAADNIMTLHAAVIAMDGSATLRA 120 Query: 275 ERRGAPQDAEQMGISLAEELLNNGAREILA 304 G AE +G+++A LL++GA +LA Sbjct: 121 TAAGPIDTAENLGMTVARALLDDGASSLLA 150 >UniRef50_UPI0001B4213A porphobilinogen deaminase n=1 Tax=Listeria monocytogenes LO28 RepID=UPI0001B4213A Length = 128 Score = 144 bits (365), Expect = 3e-33, Method: Composition-based stats. Identities = 51/124 (41%), Positives = 78/124 (62%), Gaps = 2/124 (1%) Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 +PPE+ LPAVGQGA+ IECR D + R++L +++H ET + V AER +L GGC++ Sbjct: 6 EDIPPEVCLPAVGQGALAIECRESDQQIRDMLTSIHHEETGICVEAERVFLKKLNGGCEI 65 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 PI +A + + + LVG DGS I+ E+ G + ++G +AE+LL+ GA I+ Sbjct: 66 PIAGFATRANEFVQFKGLVGNADGSIILESEQVG--ANPSEIGNKVAEDLLSEGADTIIK 123 Query: 305 EVYN 308 E+ N Sbjct: 124 ELRN 127 >UniRef50_A8CBG6 Porphobilinogen deaminase n=3 Tax=Toxoplasma gondii RepID=A8CBG6_TOXGO Length = 747 Score = 143 bits (361), Expect = 8e-33, Method: Composition-based stats. Identities = 56/163 (34%), Positives = 74/163 (45%), Gaps = 33/163 (20%) Query: 124 IVGTSSLRRQCQLAERRP--DLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL-- 179 +GT SLRRQ L P + LRGNV TR+S+++ G DA +LA AGLKRL L Sbjct: 444 RIGTCSLRRQALLYALLPPSSFQLMGLRGNVQTRMSRIEKGTLDATLLAAAGLKRLNLLS 503 Query: 180 ---------------------ESRIRAA--------LPPEISLPAVGQGAVGIECRLDDS 210 SR LP ++ +PAV QG +G++CR D+ Sbjct: 504 AMLAPSPSATPSPCPAPSPNETSRGTEPGGCVEAVLLPADVFVPAVCQGIIGVQCRSADT 563 Query: 211 RTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELI 253 LL LN + + ERA L+G C+ PI AE Sbjct: 564 GILSLLRELNSPSSRGQALCERAFLRALDGSCRTPIAGIAEWR 606 Score = 117 bits (295), Expect = 4e-25, Method: Composition-based stats. Identities = 44/96 (45%), Positives = 56/96 (58%), Gaps = 3/96 (3%) Query: 23 VKDKLMASHPGLVV---ELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAV 79 V L+ L +VPM T GD L PLA+VGGKGLF KEL++ALL + D+ V Sbjct: 253 VLASLLRVDSRLEYGELRIVPMQTTGDKELHLPLAQVGGKGLFTKELDLALLHGQVDVVV 312 Query: 80 HSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS 115 HS+KDVP E P+G + REDPRDA + + Sbjct: 313 HSLKDVPTELPEGTEIGAYLPREDPRDALIFSRKPR 348 Score = 52.4 bits (125), Expect = 2e-05, Method: Composition-based stats. Identities = 18/67 (26%), Positives = 32/67 (47%), Gaps = 5/67 (7%) Query: 247 GSYAELIDGEI-WLRALVGAPDGSQIIRGERRG----APQDAEQMGISLAEELLNNGARE 301 G A ++ ++ PDG Q+ R ER P++AE +G ++AEE+ + Sbjct: 669 GVLATPDGKQLLRFCGVLATPDGKQLFREERTVRGVRTPEEAEALGRAVAEEIKKAAGAD 728 Query: 302 ILAEVYN 308 LA++ Sbjct: 729 RLAQIKK 735 Score = 44.3 bits (104), Expect = 0.006, Method: Composition-based stats. Identities = 12/31 (38%), Positives = 15/31 (48%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPG 33 LR+ +R SPLAL QA +L P Sbjct: 160 KTPLRVGSRASPLALAQARQFVYRLALRFPD 190 >UniRef50_UPI0001742E92 Porphobilinogen deaminase n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI0001742E92 Length = 119 Score = 133 bits (335), Expect = 1e-29, Method: Composition-based stats. Identities = 32/115 (27%), Positives = 60/115 (52%), Gaps = 2/115 (1%) Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 + + +PA GQG + I+CR +D++ R LL +N E + AER + +GGC Sbjct: 1 MSEYFDTDFFMPAPGQGILCIQCRENDNKIRHLLEIINDDEVTMMCEAEREFSKIFDGGC 60 Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 PIG + + + L+ + +GS++++ E G ++ +++ LAEE+ Sbjct: 61 HTPIGCSSVIEGDTLKLKGM-FNDNGSRMLK-EVEGNKENPKEIAQKLAEEIKKE 113 >UniRef50_C4Z1K5 Putative uncharacterized protein n=1 Tax=Eubacterium eligens ATCC 27750 RepID=C4Z1K5_EUBE2 Length = 287 Score = 126 bits (317), Expect = 1e-27, Method: Composition-based stats. Identities = 48/242 (19%), Positives = 96/242 (39%), Gaps = 34/242 (14%) Query: 55 KVGGKGLFVKELEVALLENRADIAVHSMKDVPV---------EFPQGLGLVTICEREDPR 105 ++GG ++ LE AL+++ D+ + D+ + + G+ + + +R DPR Sbjct: 42 EIGGSDIY-PALE-ALIDDNIDMV---LVDMRMLVEMEKSGQQLDDGIVISGVIKRRDPR 96 Query: 106 DAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYD 165 + + ++V T S + E ++ + N+ +SKLD+ E D Sbjct: 97 YVMIRRRGT--KDVVENAVVVTDSDENAAVICEMYDNVECV-VENNIKDCMSKLDSEECD 153 Query: 166 AIILAV---AGLKRL--GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALN 220 A + A + RL GL+ + + +P GQG I S + + ++ Sbjct: 154 A-VFAFYDDIRIARLYNGLKYKYT-LMDFSDCVPPHGQGIYCILTNGKRSVIKHMFD-VS 210 Query: 221 HHETALRVTAERAMNTRLEG-----GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE 275 H TA+ E + RL C +Y ++ +I + A V G+ ++ + Sbjct: 211 HRTTAMSFDIEEDIIRRLLMNDYVKSCN----AYVKISGDKIEVYADVKGYRGNIKVQEK 266 Query: 276 RR 277 Sbjct: 267 DE 268 >UniRef50_Q401C3 Hydroxymethylbilane synthase (Fragment) n=7 Tax=Coelomata RepID=Q401C3_CAPHI Length = 109 Score = 124 bits (311), Expect = 6e-27, Method: Composition-based stats. Identities = 44/93 (47%), Positives = 59/93 (63%), Gaps = 4/93 (4%) Query: 104 PRDAFVSNN---YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD 160 P +A V + +L+ LP S+VGTSSLRR QL + P L R++RGN+ TRL KLD Sbjct: 17 PMNAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRNIRGNLNTRLRKLD 76 Query: 161 N-GEYDAIILAVAGLKRLGLESRIRAALPPEIS 192 E+ AIILA AGL+R+G ++R+ L PE Sbjct: 77 ELQEFSAIILAAAGLQRMGWQNRVGQILHPEEC 109 >UniRef50_UPI0001698669 porphobilinogen deaminase n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2' RepID=UPI0001698669 Length = 136 Score = 120 bits (302), Expect = 5e-26, Method: Composition-based stats. Identities = 64/133 (48%), Positives = 79/133 (59%), Gaps = 11/133 (8%) Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231 AGLKRLG E RI A + PE SLPA+GQGA+GIECR DD++ L+A L+H +TA V AE Sbjct: 8 AGLKRLGFEQRITAFIAPEQSLPAIGQGAIGIECRSDDAQVNALIAPLHHVDTAACVHAE 67 Query: 232 RAMNTRLEGG-----CQV-PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQ 285 RAMN RL GG C++ G A W R+ V + GE G P +AE Sbjct: 68 RAMNNRLMGGSPCADCRLRDAGVPATSGCVVWWARSTVA-----RSCVGEAEGTPDEAES 122 Query: 286 MGISLAEELLNNG 298 +G+ LAE LL G Sbjct: 123 LGVGLAERLLELG 135 >UniRef50_Q1HRH6 Hydroxymethylbilane synthase-like protein n=1 Tax=Aedes aegypti RepID=Q1HRH6_AEDAE Length = 349 Score = 118 bits (297), Expect = 2e-25, Method: Composition-based stats. Identities = 34/111 (30%), Positives = 52/111 (46%), Gaps = 6/111 (5%) Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236 +G E RI + P L AVGQGA+ +ECR +D +L+ L H ET ++ ER+ Sbjct: 1 MGWEKRIDQVIEPSEILYAVGQGALAVECRSNDEYILNMLSKLCHLETQCKILVERSFLK 60 Query: 237 RLEGGCQVPIGSYAEL------IDGEIWLRALVGAPDGSQIIRGERRGAPQ 281 L GGC P+ L + ++ V + DG IR + + + Sbjct: 61 TLGGGCSAPVAVCTSLKRKHDSKSNYLNIQGAVWSLDGKTEIRADDGCSVE 111 >UniRef50_C5G109 Porphobilinogen deaminase n=1 Tax=Microsporum canis CBS 113480 RepID=C5G109_NANOT Length = 282 Score = 112 bits (280), Expect = 2e-23, Method: Composition-based stats. Identities = 54/233 (23%), Positives = 81/233 (34%), Gaps = 48/233 (20%) Query: 84 DVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDL 143 DV + P I + Y SL LP G+I+ TS +R QL P L Sbjct: 93 DVSTKLPDSCDPAAIPVKA-------GLPYTSLQTLPEGAIIATSLVRPSAQLRRLFPTL 145 Query: 144 IIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGI 203 ++RGNV + + + A LG P QG Sbjct: 146 RFANVRGNVES------------LTIPQA----LGTVGSSTRGRPRARRR--RHQGY--- 184 Query: 204 ECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALV 263 + + + L AL + L L GC PIG E + +RA+V Sbjct: 185 ----SSAGSADRLLAL---PSVLMC--------ALRSGCNAPIGIETEWTATHLSIRAIV 229 Query: 264 GAPDGSQIIRGERRG---APQDAEQMGISLAEELLNNGAREILAEVYNGDAPA 313 + D SQ + +++ G +LA L G IL ++ N + P+ Sbjct: 230 VSLDISQSVEDAIDAMMHTKDESDAPGQALA-RLFGAGVAPILIDI-NRNQPS 280 >UniRef50_B8N6H4 Putative uncharacterized protein n=1 Tax=Aspergillus flavus NRRL3357 RepID=B8N6H4_ASPFN Length = 90 Score = 100 bits (250), Expect = 6e-20, Method: Composition-based stats. Identities = 30/79 (37%), Positives = 40/79 (50%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR+S LA+ QA +++ L PG E+ + T GD T L G K L+ Sbjct: 10 PLRIGTRRSNLAMVQAEGIRNCLQKIAPGRSFEIEALRTLGDRDQLTALYNFGAKSLWTT 69 Query: 65 ELEVALLENRADIAVHSMK 83 ELE L D+ VH +K Sbjct: 70 ELEEKLNAGELDVIVHCLK 88 >UniRef50_UPI0000D9FBB5 PREDICTED: similar to lethal (3) 02640 CG9165-PA n=1 Tax=Macaca mulatta RepID=UPI0000D9FBB5 Length = 105 Score = 99.8 bits (248), Expect = 1e-19, Method: Composition-based stats. Identities = 34/113 (30%), Positives = 45/113 (39%), Gaps = 17/113 (15%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + LRI +R+S LA Q V D+L G V LV M G+ Sbjct: 5 SNATLRIGSRRSDLARLQTLMVADRLEE--MGYKVVLVGM---------------PETGV 47 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD 114 F L LL+ D+ VHS KD+P+ G + R DPRD + Sbjct: 48 FTTFLRQKLLDGSVDLVVHSWKDLPLAEEAGTTVAATLPRADPRDLIIIRKDA 100 >UniRef50_UPI0001C35DE1 porphobilinogen deaminase n=1 Tax=Clostridium hathewayi DSM 13479 RepID=UPI0001C35DE1 Length = 121 Score = 89.0 bits (220), Expect = 2e-16, Method: Composition-based stats. Identities = 25/112 (22%), Positives = 47/112 (41%), Gaps = 3/112 (2%) Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 E +PA GQG + +E R++D R E+ + + + ER + L+ GC Sbjct: 13 FHYFACEAFIPAGGQGILAVEGRIED-RICEMAVRIQDEDAKTCLMLERKILKLLDAGCH 71 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295 P+G Y+ + EI + + + + R G + + + A+ L Sbjct: 72 EPVGVYSRIRGEEIEVFGI--SRRDRETKRVYLTGGIGELDLLAERAAKGLR 121 >UniRef50_C5U771 Porphobilinogen deaminase n=1 Tax=Methanocaldococcus infernus ME RepID=C5U771_9EURY Length = 89 Score = 73.6 bits (180), Expect = 9e-12, Method: Composition-based stats. Identities = 24/83 (28%), Positives = 34/83 (40%), Gaps = 3/83 (3%) Query: 217 AALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER 276 +N +T L TAER L GC VP G++A+ + L+ V D Sbjct: 2 EKINDKKTFLETTAERKALNELGCGCHVPFGAFAKYEGKRLMLKVAVANKDRVIKKESSI 61 Query: 277 RGAPQD---AEQMGISLAEELLN 296 + AE++G SL EL Sbjct: 62 CCEVDEIEKAEKLGESLGRELRR 84 >UniRef50_Q4EB45 Porphobilinogen deaminase n=1 Tax=Wolbachia endosymbiont of Drosophila ananassae RepID=Q4EB45_9RICK Length = 62 Score = 62.8 bits (152), Expect = 1e-08, Method: Composition-based stats. Identities = 20/50 (40%), Positives = 30/50 (60%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAK 55 ++I TR S LA+ QA K KL+ S P L +E+V + + GD + LA+ Sbjct: 13 VKIGTRGSKLAVVQALEAKQKLLDSFPNLSIEIVKIKSSGDKYANANLAE 62 >UniRef50_B5XH53 Porphobilinogen deaminase n=1 Tax=Salmo salar RepID=B5XH53_SALSA Length = 55 Score = 59.7 bits (144), Expect = 1e-07, Method: Composition-based stats. Identities = 15/39 (38%), Positives = 22/39 (56%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPM 41 V+RI TR S LA Q V +KL +P + +E+V + Sbjct: 16 SRVIRIGTRNSQLARIQTDSVAEKLKGLYPDVHIEIVGI 54 >UniRef50_C2BR76 Putative uncharacterized protein (Fragment) n=1 Tax=Corynebacterium pseudogenitalium ATCC 33035 RepID=C2BR76_9CORY Length = 62 Score = 59.0 bits (142), Expect = 2e-07, Method: Composition-based stats. Identities = 16/62 (25%), Positives = 32/62 (51%) Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 P+ + + ++ +R V A DGS+ + G+ +A +G +++EL GA E+L Sbjct: 1 APVAATSRWDGDQLTVRGGVFALDGSRQLTATASGSAAEAADLGARISDELFAGGAAELL 60 Query: 304 AE 305 + Sbjct: 61 GK 62 >UniRef50_UPI0000D537E6 hypothetical protein P700755_22735 n=1 Tax=Psychroflexus torquis ATCC 700755 RepID=UPI0000D537E6 Length = 356 Score = 55.5 bits (133), Expect = 3e-06, Method: Composition-based stats. Identities = 46/234 (19%), Positives = 83/234 (35%), Gaps = 38/234 (16%) Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127 +L + D+ S D + +GL + + R++P V+N+ + L G+ + Sbjct: 49 QSLRDGAGDLVAMSAFDWQQQDVEGLIIAGLLTRKEPTWVLVANDKP--EYLKQGAYILC 106 Query: 128 S--SLRRQCQLAERRPDLIIRSL-----RGNVGTRLSKLDN-------------GEYDAI 167 LRR Q+ R DL + ++ R N +S+LD G D Sbjct: 107 DHELLRR--QMMRLRGDLTLETMEEMGKRLNAAATISELDEEDIWPWVEGLLKNGNIDGF 164 Query: 168 ILAVA--GLKR-------LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAA 218 I+ A R LGL+ + E +P G + R + + Sbjct: 165 IVPRAIHASHRMKSRRHTLGLQRDNSES-NRERFIPPPLHGFTMLVGRNGFPKAS--IQD 221 Query: 219 LNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQII 272 + L E A+ LE + +G++ E +I + DG + + Sbjct: 222 MVDQSAELAYRLEAAILESLEPSLRPIVGAFVEQR--KIATILKKASEDGDEAL 273 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_B7LU53 Porphobilinogen deaminase n=87 Tax=cellular orga... 443 e-123 UniRef50_B5FN93 Porphobilinogen deaminase n=168 Tax=cellular org... 437 e-121 UniRef50_Q3ACT3 Porphobilinogen deaminase n=2 Tax=Bacteria RepID... 436 e-121 UniRef50_C0QU69 Porphobilinogen deaminase n=4 Tax=Bacteria RepID... 434 e-120 UniRef50_B5YJZ4 Porphobilinogen deaminase n=2 Tax=Bacteria RepID... 430 e-119 UniRef50_C0Q9U2 HemC n=2 Tax=Bacteria RepID=C0Q9U2_DESAH 429 e-119 UniRef50_Q8YVU6 Porphobilinogen deaminase n=50 Tax=cellular orga... 424 e-117 UniRef50_D1BNZ5 Porphobilinogen deaminase n=3 Tax=Veillonella Re... 423 e-117 UniRef50_Q8DIE4 Porphobilinogen deaminase n=11 Tax=cellular orga... 418 e-115 UniRef50_Q65GK1 Porphobilinogen deaminase n=98 Tax=Bacillales Re... 414 e-114 UniRef50_Q0I178 Porphobilinogen deaminase n=45 Tax=Bacteria RepI... 414 e-114 UniRef50_A1AUE7 Porphobilinogen deaminase n=44 Tax=Bacteria RepI... 413 e-114 UniRef50_C9KL85 Hydroxymethylbilane synthase n=1 Tax=Mitsuokella... 413 e-114 UniRef50_B5EBG8 Porphobilinogen deaminase n=166 Tax=Bacteria Rep... 411 e-113 UniRef50_A6TJD5 Porphobilinogen deaminase n=2 Tax=Firmicutes Rep... 410 e-113 UniRef50_Q31PM2 Porphobilinogen deaminase n=8 Tax=cellular organ... 404 e-111 UniRef50_C6HUG2 Porphobilinogen deaminase n=1 Tax=Leptospirillum... 403 e-111 UniRef50_Q2RJ26 Porphobilinogen deaminase n=5 Tax=Clostridia Rep... 400 e-110 UniRef50_P08397 Porphobilinogen deaminase n=59 Tax=Chordata RepI... 397 e-109 UniRef50_Q5ZRY6 Porphobilinogen deaminase n=6 Tax=Legionella Rep... 397 e-109 UniRef50_Q30Y29 Porphobilinogen deaminase n=13 Tax=Bacteria RepI... 394 e-108 UniRef50_B2A1G7 Porphobilinogen deaminase n=1 Tax=Natranaerobius... 394 e-108 UniRef50_Q4L709 Porphobilinogen deaminase n=88 Tax=Bacillales Re... 393 e-108 UniRef50_B3E2H7 Porphobilinogen deaminase n=3 Tax=Proteobacteria... 392 e-107 UniRef50_C9R7U0 Porphobilinogen deaminase n=1 Tax=Ammonifex dege... 389 e-107 UniRef50_B3QWI1 Porphobilinogen deaminase n=12 Tax=Chlorobiaceae... 388 e-106 UniRef50_Q54P93 Porphobilinogen deaminase n=1 Tax=Dictyostelium ... 387 e-106 UniRef50_A6WXJ2 Porphobilinogen deaminase n=56 Tax=cellular orga... 386 e-106 UniRef50_Q2LQU2 Porphobilinogen deaminase n=1 Tax=Syntrophus aci... 385 e-106 UniRef50_A7NKU8 Porphobilinogen deaminase n=5 Tax=Bacteria RepID... 384 e-105 UniRef50_B2S842 Porphobilinogen deaminase n=38 Tax=Rhizobiales R... 384 e-105 UniRef50_A8PKX6 Porphobilinogen deaminase n=2 Tax=Gammaproteobac... 383 e-105 UniRef50_Q1J288 Porphobilinogen deaminase n=5 Tax=Deinococci Rep... 382 e-104 UniRef50_A3ETN3 Porphobilinogen deaminase n=2 Tax=Leptospirillum... 382 e-104 UniRef50_B6FXV9 Putative uncharacterized protein n=1 Tax=Clostri... 381 e-104 UniRef50_Q180R9 Porphobilinogen deaminase n=11 Tax=Bacteria RepI... 380 e-104 UniRef50_A7GYU4 Porphobilinogen deaminase n=34 Tax=Campylobacter... 379 e-104 UniRef50_A6Q7Y4 Porphobilinogen deaminase n=7 Tax=Epsilonproteob... 377 e-103 UniRef50_D0LUE1 Porphobilinogen deaminase n=1 Tax=Haliangium och... 377 e-103 UniRef50_Q43316 Porphobilinogen deaminase, chloroplastic n=61 Ta... 375 e-103 UniRef50_O94048 Porphobilinogen deaminase n=53 Tax=Saccharomycet... 373 e-102 UniRef50_Q8RFP5 Porphobilinogen deaminase n=16 Tax=Fusobacteriac... 373 e-102 UniRef50_B3T8H9 Putative Porphobilinogen deaminase, dipyromethan... 372 e-102 UniRef50_A8LIJ6 Porphobilinogen deaminase n=11 Tax=Alphaproteoba... 372 e-102 UniRef50_D2R3S6 Porphobilinogen deaminase n=2 Tax=Planctomycetac... 372 e-102 UniRef50_P28789 Porphobilinogen deaminase n=18 Tax=Saccharomycet... 370 e-101 UniRef50_A5VM67 Porphobilinogen deaminase n=9 Tax=Lactobacillus ... 370 e-101 UniRef50_UPI00017922DC PREDICTED: similar to porphobilinogen dea... 370 e-101 UniRef50_UPI0000583C22 PREDICTED: hypothetical protein n=1 Tax=S... 370 e-101 UniRef50_A9A1A1 Probable porphobilinogen deaminase n=3 Tax=Thaum... 369 e-101 UniRef50_C8WXM9 Porphobilinogen deaminase n=2 Tax=Alicyclobacill... 369 e-101 UniRef50_UPI0001926E0E PREDICTED: similar to hydroxymethylbilane... 368 e-100 UniRef50_B0K2L4 Porphobilinogen deaminase n=7 Tax=Bacteria RepID... 368 e-100 UniRef50_C1CYD9 Porphobilinogen deaminase n=3 Tax=Deinococci Rep... 367 e-100 UniRef50_Q3YSA8 Porphobilinogen deaminase n=17 Tax=Rickettsiales... 367 e-100 UniRef50_C3WGN0 Porphobilinogen deaminase n=5 Tax=Fusobacterium ... 366 e-100 UniRef50_D1CBT4 Porphobilinogen deaminase n=1 Tax=Thermobaculum ... 364 2e-99 UniRef50_C3XEZ5 Porphobilinogen deaminase n=3 Tax=Campylobactera... 364 2e-99 UniRef50_Q5HBG1 Porphobilinogen deaminase n=2 Tax=Ehrlichia rumi... 362 9e-99 UniRef50_C6XGK7 Porphobilinogen deaminase n=1 Tax=Candidatus Lib... 360 4e-98 UniRef50_Q2S2A6 Porphobilinogen deaminase n=1 Tax=Salinibacter r... 359 6e-98 UniRef50_D0NJW2 Porphobilinogen deaminase n=2 Tax=Phytophthora i... 358 1e-97 UniRef50_Q4HT06 Porphobilinogen deaminase n=1 Tax=Campylobacter ... 356 7e-97 UniRef50_C7N5L0 Porphobilinogen deaminase n=2 Tax=Slackia RepID=... 355 8e-97 UniRef50_B3U3W9 Hydroxymethylbilane synthetase n=1 Tax=Oxyrrhis ... 355 1e-96 UniRef50_A8U3E9 Porphobilinogen deaminase n=1 Tax=alpha proteoba... 355 1e-96 UniRef50_A6DBT5 Porphobilinogen deaminase n=1 Tax=Caminibacter m... 354 2e-96 UniRef50_A6GVP0 Hydroxymethylbilane synthase n=18 Tax=Bacteroide... 354 2e-96 UniRef50_A6GB01 Porphobilinogen deaminase n=2 Tax=Bacteria RepID... 353 6e-96 UniRef50_C4Z552 Porphobilinogen deaminase n=8 Tax=Bacteria RepID... 352 7e-96 UniRef50_Q11XT5 Porphobilinogen deaminase n=8 Tax=Bacteria RepID... 351 2e-95 UniRef50_UPI00006CBE06 porphobilinogen deaminase family protein ... 351 2e-95 UniRef50_A9FDP9 Porphobilinogen deaminase n=1 Tax=Sorangium cell... 351 2e-95 UniRef50_C1AA38 Porphobilinogen deaminase n=1 Tax=Gemmatimonas a... 350 4e-95 UniRef50_Q1V167 Hydroxymethylbilane synthase n=3 Tax=Candidatus ... 350 4e-95 UniRef50_B2W5W6 Porphobilinogen deaminase n=2 Tax=Pleosporineae ... 350 4e-95 UniRef50_A3CL78 Porphobilinogen deaminase n=1 Tax=Streptococcus ... 349 6e-95 UniRef50_A0LRF1 Porphobilinogen deaminase n=1 Tax=Acidothermus c... 349 7e-95 UniRef50_C6WZF5 Porphobilinogen deaminase n=1 Tax=Flavobacteriac... 348 1e-94 UniRef50_C3PNS9 Porphobilinogen deaminase n=15 Tax=Rickettsia Re... 347 3e-94 UniRef50_A3ZKX4 Porphobilinogen deaminase n=1 Tax=Blastopirellul... 346 6e-94 UniRef50_A8MDU3 Probable porphobilinogen deaminase n=2 Tax=Therm... 346 8e-94 UniRef50_A2Q9P7 Catalytic activity: 4 porphobilinogen+H(2)O<=>hy... 344 2e-93 UniRef50_C0YV01 Hydroxymethylbilane synthase n=1 Tax=Chryseobact... 344 2e-93 UniRef50_C4ZFT9 Porphobilinogen deaminase n=1 Tax=Eubacterium re... 344 3e-93 UniRef50_C1ZK04 Porphobilinogen deaminase n=1 Tax=Planctomyces l... 342 9e-93 UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia... 342 1e-92 UniRef50_A2BL26 Probable porphobilinogen deaminase n=2 Tax=Therm... 342 1e-92 UniRef50_Q0TQG4 Porphobilinogen deaminase n=32 Tax=Clostridium R... 342 1e-92 UniRef50_B3DZQ6 Porphobilinogen deaminase n=1 Tax=Methylacidiphi... 341 2e-92 UniRef50_Q0BX92 Porphobilinogen deaminase n=1 Tax=Hyphomonas nep... 341 2e-92 UniRef50_A5CDH4 Porphobilinogen deaminase n=2 Tax=Orientia tsuts... 340 4e-92 UniRef50_B8MVK7 Porphobilinogen deaminase, putative n=1 Tax=Tala... 338 2e-91 UniRef50_C1F251 Hydroxymethylbilane synthase n=1 Tax=Acidobacter... 337 2e-91 UniRef50_Q09899 Porphobilinogen deaminase n=2 Tax=Schizosaccharo... 337 3e-91 UniRef50_C7NFP7 Hydroxymethylbilane synthase n=7 Tax=Actinomycet... 337 4e-91 UniRef50_B0D5Q2 Predicted protein n=1 Tax=Laccaria bicolor S238N... 337 5e-91 UniRef50_C8WIZ2 Porphobilinogen deaminase n=2 Tax=Coriobacteriac... 336 5e-91 UniRef50_A4XK06 Porphobilinogen deaminase n=2 Tax=Clostridia Rep... 335 9e-91 UniRef50_B5G8F1 Porphobilinogen deaminase n=1 Tax=Streptomyces s... 335 9e-91 UniRef50_D0J8N1 Porphobilinogen deaminase n=2 Tax=Blattabacteriu... 335 1e-90 UniRef50_Q8TXC8 Probable porphobilinogen deaminase n=1 Tax=Metha... 335 2e-90 UniRef50_A8SQW4 Putative uncharacterized protein n=1 Tax=Coproco... 334 2e-90 UniRef50_B9XN63 Porphobilinogen deaminase n=1 Tax=bacterium Elli... 334 2e-90 UniRef50_A8MGE4 Porphobilinogen deaminase n=30 Tax=cellular orga... 334 3e-90 UniRef50_B8GXG1 Porphobilinogen deaminase n=8 Tax=Caulobacterace... 333 3e-90 UniRef50_Q82P95 Porphobilinogen deaminase 2 n=14 Tax=Actinomycet... 333 4e-90 UniRef50_C6XKH7 Porphobilinogen deaminase n=1 Tax=Hirschia balti... 333 5e-90 UniRef50_Q7UPN0 Porphobilinogen deaminase n=1 Tax=Rhodopirellula... 332 7e-90 UniRef50_O29026 Probable porphobilinogen deaminase n=1 Tax=Archa... 332 1e-89 UniRef50_A4QB59 Porphobilinogen deaminase n=15 Tax=Corynebacteri... 331 2e-89 UniRef50_B2IAW6 Porphobilinogen deaminase n=4 Tax=Alphaproteobac... 330 4e-89 UniRef50_Q46CH0 Probable porphobilinogen deaminase n=7 Tax=Eurya... 330 4e-89 UniRef50_B6W7F3 Putative uncharacterized protein n=1 Tax=Anaeroc... 330 5e-89 UniRef50_C4QMG7 Hydroxymethylbilane synthase (Porphobilinogen de... 328 1e-88 UniRef50_C2FZW8 Porphobilinogen deaminase n=2 Tax=Sphingobacteri... 328 1e-88 UniRef50_A0DD68 Chromosome undetermined scaffold_46, whole genom... 328 2e-88 UniRef50_Q4T5L1 Chromosome undetermined SCAF9206, whole genome s... 328 2e-88 UniRef50_D2RH82 Porphobilinogen deaminase n=2 Tax=Archaeoglobace... 328 2e-88 UniRef50_D1BFI8 Hydroxymethylbilane synthase n=4 Tax=Actinomycet... 327 2e-88 UniRef50_C5RMN3 Porphobilinogen deaminase n=1 Tax=Clostridium ce... 327 3e-88 UniRef50_B3RTQ8 Putative uncharacterized protein n=1 Tax=Trichop... 327 3e-88 UniRef50_C6XST0 Porphobilinogen deaminase n=2 Tax=Pedobacter Rep... 327 4e-88 UniRef50_Q47LA7 Porphobilinogen deaminase n=3 Tax=Actinomycetale... 326 7e-88 UniRef50_A3MLK5 Porphobilinogen deaminase n=155 Tax=Proteobacter... 326 7e-88 UniRef50_UPI000174444E Hydroxymethylbilane synthase n=1 Tax=Verr... 325 9e-88 UniRef50_A8AAB4 Probable porphobilinogen deaminase n=1 Tax=Ignic... 325 9e-88 UniRef50_A4CHM3 Porphobilinogen deaminase n=4 Tax=Bacteroidetes ... 325 1e-87 UniRef50_C1TM53 Porphobilinogen deaminase n=1 Tax=Dethiosulfovib... 324 2e-87 UniRef50_C9M5W1 Hydroxymethylbilane synthase n=1 Tax=Jonquetella... 323 4e-87 UniRef50_C0BZ93 Putative uncharacterized protein n=1 Tax=Clostri... 323 4e-87 UniRef50_C2GGB5 Porphobilinogen deaminase n=2 Tax=Corynebacteriu... 323 6e-87 UniRef50_D2NS36 Porphobilinogen deaminase n=2 Tax=Micrococcaceae... 323 7e-87 UniRef50_A4WN24 Probable porphobilinogen deaminase n=3 Tax=Therm... 322 8e-87 UniRef50_Q2NEP4 HemC n=4 Tax=Methanobacteriaceae RepID=Q2NEP4_METST 322 1e-86 UniRef50_Q9F7M2 Predicted porphobilinogen deaminase n=2 Tax=Bact... 321 2e-86 UniRef50_C6R3Y0 Hydroxymethylbilane synthase n=1 Tax=Rothia muci... 320 4e-86 UniRef50_D1VCA1 Porphobilinogen deaminase n=1 Tax=Frankia sp. Eu... 320 4e-86 UniRef50_Q57989 Probable porphobilinogen deaminase n=11 Tax=Meth... 320 5e-86 UniRef50_A0QLI0 Porphobilinogen deaminase n=69 Tax=Actinomycetal... 318 2e-85 UniRef50_UPI0001BC2D4C glutamyl-tRNA reductase n=1 Tax=Brevibact... 318 2e-85 UniRef50_Q8D2W2 HemC protein n=1 Tax=Wigglesworthia glossinidia ... 317 2e-85 UniRef50_D1C4S0 Porphobilinogen deaminase n=1 Tax=Sphaerobacter ... 317 3e-85 UniRef50_A1DGB8 Porphobilinogen deaminase n=1 Tax=Neosartorya fi... 317 5e-85 UniRef50_B3LB83 Porphobilinogen deaminase, putative n=1 Tax=Plas... 316 8e-85 UniRef50_C5CB88 Porphobilinogen deaminase n=5 Tax=Actinomycetale... 315 1e-84 UniRef50_Q1EPC8 Porphobilinogen deaminase, chloroplast (Hydroxym... 315 2e-84 UniRef50_O26960 Probable porphobilinogen deaminase n=1 Tax=Metha... 314 2e-84 UniRef50_C9RPT6 Porphobilinogen deaminase n=1 Tax=Fibrobacter su... 314 2e-84 UniRef50_B6JII8 Porphobilinogen deaminase n=11 Tax=Bradyrhizobia... 313 5e-84 UniRef50_Q6AHF1 Porphobilinogen deaminase n=5 Tax=Actinobacteria... 312 1e-83 UniRef50_C5EV71 Pyruvate ferredoxin/flavodoxin oxidoreductase n=... 310 3e-83 UniRef50_A3VPD5 Porphobilinogen deaminase n=1 Tax=Parvularcula b... 310 5e-83 UniRef50_A6LKX0 Porphobilinogen deaminase n=1 Tax=Thermosipho me... 308 1e-82 UniRef50_B2ULP1 Porphobilinogen deaminase n=1 Tax=Akkermansia mu... 308 1e-82 UniRef50_A8PWJ5 Putative uncharacterized protein n=1 Tax=Malasse... 307 3e-82 UniRef50_Q0ATQ1 Porphobilinogen deaminase n=3 Tax=Alphaproteobac... 307 3e-82 UniRef50_Q6L2G8 Probable porphobilinogen deaminase n=1 Tax=Picro... 306 6e-82 UniRef50_A2SQU4 Uroporphyrin-III C-methyltransferase n=11 Tax=Eu... 306 6e-82 UniRef50_Q5KKQ0 Hydroxymethylbilane synthase, putative n=2 Tax=F... 305 2e-81 UniRef50_D1B7N1 Porphobilinogen deaminase n=1 Tax=Thermanaerovib... 304 2e-81 UniRef50_C6V4N6 Porphobilinogen deaminase n=2 Tax=Neorickettsia ... 303 4e-81 UniRef50_Q1AUK3 Porphobilinogen deaminase n=1 Tax=Rubrobacter xy... 302 8e-81 UniRef50_B5GJG2 Porphobilinogen deaminase n=3 Tax=Streptomyces R... 302 1e-80 UniRef50_A4YD92 Probable porphobilinogen deaminase n=1 Tax=Metal... 301 2e-80 UniRef50_C7R376 Porphobilinogen deaminase n=1 Tax=Jonesia denitr... 301 3e-80 UniRef50_C7M2H5 Porphobilinogen deaminase n=1 Tax=Acidimicrobium... 300 6e-80 UniRef50_D1JID7 Porphobilinogen deaminase n=1 Tax=uncultured arc... 299 7e-80 UniRef50_C7DH16 Porphobilinogen deaminase n=1 Tax=Candidatus Mic... 299 9e-80 UniRef50_A9HK97 Porphobilinogen deaminase n=12 Tax=Acetobacterac... 297 3e-79 UniRef50_C4JRY9 Porphobilinogen deaminase n=1 Tax=Uncinocarpus r... 296 6e-79 UniRef50_B5JN62 Porphobilinogen deaminase n=1 Tax=Verrucomicrobi... 295 1e-78 UniRef50_C3MZR8 Probable porphobilinogen deaminase n=11 Tax=Sulf... 295 2e-78 UniRef50_D2RNT2 Porphobilinogen deaminase n=1 Tax=Acidaminococcu... 293 6e-78 UniRef50_C0W553 Porphobilinogen deaminase n=2 Tax=Actinomycetale... 293 6e-78 UniRef50_Q4PFH9 Putative uncharacterized protein n=1 Tax=Ustilag... 293 7e-78 UniRef50_Q2FTK7 Hydroxymethylbilane synthase n=3 Tax=Methanomicr... 292 1e-77 UniRef50_Q8I5V3 Porphobilinogen deaminase n=6 Tax=Plasmodium Rep... 291 2e-77 UniRef50_A2BFN7 Hydroxymethylbilane synthase (Fragment) n=6 Tax=... 290 6e-77 UniRef50_Q97B26 Probable porphobilinogen deaminase n=2 Tax=Therm... 289 7e-77 UniRef50_B0WMK9 Porphobilinogen deaminase n=1 Tax=Culex quinquef... 286 6e-76 UniRef50_C8WDJ7 Porphobilinogen deaminase n=3 Tax=Zymomonas mobi... 285 1e-75 UniRef50_C1XV35 Porphobilinogen deaminase n=2 Tax=Meiothermus Re... 284 3e-75 UniRef50_Q93A65 Porphobilinogen deaminase n=1 Tax=uncultured bac... 283 6e-75 UniRef50_B4D5X7 Porphobilinogen deaminase n=1 Tax=Chthoniobacter... 283 8e-75 UniRef50_Q9Y9J0 Probable porphobilinogen deaminase n=1 Tax=Aerop... 282 9e-75 UniRef50_C5C5B3 Porphobilinogen deaminase n=6 Tax=Actinomycetale... 282 1e-74 UniRef50_Q0RS16 Porphobilinogen deaminase 1 (PBG 1) (Hydroxymeth... 279 1e-73 UniRef50_Q1GP41 Porphobilinogen deaminase n=7 Tax=Sphingomonadal... 278 1e-73 UniRef50_UPI000038E213 porphobilinogen deaminase n=1 Tax=Ferropl... 273 5e-72 UniRef50_A9V9E0 Predicted protein n=1 Tax=Monosiga brevicollis R... 271 3e-71 UniRef50_Q83H95 Porphobilinogen deaminase n=2 Tax=Tropheryma whi... 269 1e-70 UniRef50_A5K0J5 Porphobilinogen deaminase, putative n=1 Tax=Plas... 268 2e-70 UniRef50_UPI0001C31A39 porphobilinogen deaminase n=1 Tax=Conexib... 266 6e-70 UniRef50_A7BMK1 Porphobilinogen deaminase n=1 Tax=Beggiatoa sp. ... 264 4e-69 UniRef50_B0SF66 Bifunctional porphobilinogen deaminase/uroporphy... 263 5e-69 UniRef50_Q86ET2 Clone ZZD1450 mRNA sequence n=3 Tax=Schistosoma ... 263 5e-69 UniRef50_Q04X38 Bifunctional porphobilinogen deaminase/uroporphy... 263 7e-69 UniRef50_B1ZV87 Porphobilinogen deaminase n=2 Tax=Opitutaceae Re... 254 3e-66 UniRef50_Q6MHU0 Hydroxymethylbilane synthase n=1 Tax=Bdellovibri... 239 1e-61 UniRef50_C0EAN0 Putative uncharacterized protein n=1 Tax=Clostri... 238 3e-61 UniRef50_Q4E9D5 Porphobilinogen deaminase (Fragment) n=1 Tax=Wol... 233 6e-60 UniRef50_A8I2X7 Porphobilinogen deaminase n=1 Tax=Chlamydomonas ... 230 4e-59 UniRef50_B6YQR9 Hydroxymethylbilane synthase/uroporphyrin-III C-... 229 7e-59 UniRef50_B4UXX3 Porphobilinogen deaminase 2 (Fragment) n=1 Tax=S... 227 3e-58 UniRef50_Q6MEK3 Putative Porphobilinogen deaminase n=2 Tax=Parac... 221 3e-56 UniRef50_Q6Q923 Predicted porphobilinogen deaminase n=2 Tax=envi... 211 3e-53 UniRef50_Q9PK95 Probable porphobilinogen deaminase n=13 Tax=Chla... 208 2e-52 UniRef50_C5LJF7 Porphobilinogen deaminase, putative n=5 Tax=Perk... 205 1e-51 UniRef50_Q9HMY5 Probable porphobilinogen deaminase n=2 Tax=Halob... 203 7e-51 UniRef50_D0RNS6 Putative porphobilinogen deaminase (Pbg)(Hydroxy... 203 1e-50 UniRef50_Q18ES3 Hydroxymethylbilane synthase (Porphobilinogen de... 187 3e-46 UniRef50_UPI000155526F PREDICTED: similar to hydroxymethylbilane... 174 4e-42 UniRef50_B0KCR7 Porphobilinogen deaminase n=3 Tax=Thermoanaeroba... 163 8e-39 UniRef50_C0DZX9 Putative uncharacterized protein n=1 Tax=Coryneb... 152 2e-35 UniRef50_UPI0001B4213A porphobilinogen deaminase n=1 Tax=Listeri... 142 2e-32 UniRef50_A8CBG6 Porphobilinogen deaminase n=3 Tax=Toxoplasma gon... 141 3e-32 UniRef50_Q401C3 Hydroxymethylbilane synthase (Fragment) n=7 Tax=... 133 9e-30 UniRef50_UPI0001742E92 Porphobilinogen deaminase n=1 Tax=candida... 129 2e-28 UniRef50_C4Z1K5 Putative uncharacterized protein n=1 Tax=Eubacte... 122 1e-26 UniRef50_Q1HRH6 Hydroxymethylbilane synthase-like protein n=1 Ta... 116 1e-24 UniRef50_UPI0001698669 porphobilinogen deaminase n=1 Tax=Endorif... 116 1e-24 UniRef50_C5G109 Porphobilinogen deaminase n=1 Tax=Microsporum ca... 110 8e-23 UniRef50_UPI0000D537E6 hypothetical protein P700755_22735 n=1 Ta... 104 6e-21 UniRef50_UPI0000D9FBB5 PREDICTED: similar to lethal (3) 02640 CG... 100 8e-20 UniRef50_B8N6H4 Putative uncharacterized protein n=1 Tax=Aspergi... 99 2e-19 UniRef50_UPI0001C35DE1 porphobilinogen deaminase n=1 Tax=Clostri... 88 4e-16 UniRef50_C5U771 Porphobilinogen deaminase n=1 Tax=Methanocaldoco... 75 4e-12 UniRef50_Q4EB45 Porphobilinogen deaminase n=1 Tax=Wolbachia endo... 62 2e-08 UniRef50_B5XH53 Porphobilinogen deaminase n=1 Tax=Salmo salar Re... 60 1e-07 UniRef50_C2BR76 Putative uncharacterized protein (Fragment) n=1 ... 56 2e-06 Sequences not found previously or not previously below threshold: CONVERGED! >UniRef50_B7LU53 Porphobilinogen deaminase n=87 Tax=cellular organisms RepID=HEM3_ESCF3 Length = 313 Score = 443 bits (1141), Expect = e-123, Method: Composition-based stats. Identities = 296/312 (94%), Positives = 302/312 (96%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 MLDNVLRIATRQSPLALWQAHYVKD LMA HPGL VELVPMVTRGDVILDTPLAKVGGKG Sbjct: 1 MLDNVLRIATRQSPLALWQAHYVKDALMAKHPGLTVELVPMVTRGDVILDTPLAKVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN Y SLD LP Sbjct: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNKYASLDELP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE Sbjct: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 SRIR ALPPE+SLPAVGQGAVGIECRLDD+RTRELLAALNH ETALRVTAERAMNTRLEG Sbjct: 181 SRIRDALPPEVSLPAVGQGAVGIECRLDDTRTRELLAALNHPETALRVTAERAMNTRLEG 240 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPIGSYAELI GEIWLRALVGAPDGSQ+IRGERRG+PQDAE+MGISLAEELLNNGAR Sbjct: 241 GCQVPIGSYAELIGGEIWLRALVGAPDGSQMIRGERRGSPQDAEKMGISLAEELLNNGAR 300 Query: 301 EILAEVYNGDAP 312 ILA+VYNGDAP Sbjct: 301 AILADVYNGDAP 312 >UniRef50_B5FN93 Porphobilinogen deaminase n=168 Tax=cellular organisms RepID=HEM3_SALDC Length = 313 Score = 437 bits (1124), Expect = e-121, Method: Composition-based stats. Identities = 279/313 (89%), Positives = 294/313 (93%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 MLDNVLRIATRQSPLALWQAHYVKD LMA+HPGL VELVPMVTRGDVILDTPLAKVGGKG Sbjct: 1 MLDNVLRIATRQSPLALWQAHYVKDALMATHPGLTVELVPMVTRGDVILDTPLAKVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKELE+ALLE RADIAVHSMKDVPV FP GLGLVTICEREDPRDAFVSN Y SLD LP Sbjct: 61 LFVKELEIALLEKRADIAVHSMKDVPVAFPDGLGLVTICEREDPRDAFVSNKYHSLDDLP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRL KLDNG+YDAIILAVAGLKRLGLE Sbjct: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLGKLDNGDYDAIILAVAGLKRLGLE 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 SRIR ALPP++SLPAVGQGAVGIECRLDD+RT+ LLA LNH +TALRVTAERAMNTRLEG Sbjct: 181 SRIRTALPPDVSLPAVGQGAVGIECRLDDARTQALLAPLNHSQTALRVTAERAMNTRLEG 240 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPIGSYAE+I+GEIWLRALVGAPDGS ++RGERRG+P+ AEQMGISLAEELL NGAR Sbjct: 241 GCQVPIGSYAEIINGEIWLRALVGAPDGSVMVRGERRGSPEQAEQMGISLAEELLENGAR 300 Query: 301 EILAEVYNGDAPA 313 IL EVYNG+ PA Sbjct: 301 AILTEVYNGETPA 313 >UniRef50_Q3ACT3 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=HEM3_CARHZ Length = 311 Score = 436 bits (1121), Expect = e-121, Method: Composition-based stats. Identities = 146/311 (46%), Positives = 202/311 (64%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + + + +R S LALWQ ++V ++L HP + ++V M T+GD ILD LAK+G KGL Sbjct: 1 MKKEVIVGSRDSALALWQTNWVVERLSKIHPEINFKIVTMKTKGDKILDVALAKIGDKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F KELE ALL D+AVHSMKD+P P+GL + CERE P D F+S LP Sbjct: 61 FTKELEHALLNKTIDMAVHSMKDLPTVLPEGLKIGAFCEREYPGDVFISPKGFKFLELPQ 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ +GTSSLRR Q+ RPDL LRGN+ TR K++ + D IILA AG+KRLG E Sbjct: 121 GARIGTSSLRRIAQILAVRPDLQAIPLRGNLPTRFRKMEEMDLDGIILAYAGVKRLGYED 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 +I L ++ LPAVGQG++G+E R DD+ ELL ++H T + AERA RLEGG Sbjct: 181 KITEMLSFDLCLPAVGQGSIGVEIRADDTFIEELLKPIDHFATNRAIRAERAFLKRLEGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 CQ+PIG+Y+E+ + + L+ +V + DG +I+GE+ G+ ++ E++GISLAEELL GA++ Sbjct: 241 CQIPIGAYSEVKENRLHLKGVVASLDGKLVIKGEKEGSIEEPEKVGISLAEELLTKGAQK 300 Query: 302 ILAEVYNGDAP 312 IL E+ Sbjct: 301 ILEEIRRDANE 311 >UniRef50_C0QU69 Porphobilinogen deaminase n=4 Tax=Bacteria RepID=C0QU69_PERMH Length = 308 Score = 434 bits (1117), Expect = e-120, Method: Composition-based stats. Identities = 171/306 (55%), Positives = 229/306 (74%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR+S LALWQA+Y+ D+L P L VELV +VT+GD ILD PLAKVGGKGLFVKE Sbjct: 3 IRIGTRKSKLALWQANYIADQLKKHFPDLEVELVKIVTKGDKILDVPLAKVGGKGLFVKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E A+L N DIAVHS+KDVP FP+GLGLV I EREDPRDAF+S Y+S++ +P G+++ Sbjct: 63 IEEAMLRNEIDIAVHSLKDVPTYFPEGLGLVAITEREDPRDAFLSVKYNSIEDMPEGAVL 122 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR+ Q+ +R D+ I LRGNV TR+ KL+ G+YD IILA AGLKRLGLE ++R Sbjct: 123 GTSSLRRKAQIMMKRKDIRIEDLRGNVDTRIRKLEEGQYDGIILAYAGLKRLGLEGKVRQ 182 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L P+ +PAV QG +GIE RLDD +TRE+++ LNH E+ +R AERA LEGGCQVP Sbjct: 183 ILQPDYMIPAVAQGFLGIEARLDDEKTREIVSVLNHRESEIRAKAERAFLKTLEGGCQVP 242 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 + Y+E+++G++ + V G ++ R G+ +DAE +G+ LAE+LL++GA+E+L E Sbjct: 243 LAGYSEIVNGKLKITGFVSDLTGDRVFRDSMEGSLEDAESLGVKLAEKLLSDGAKEVLEE 302 Query: 306 VYNGDA 311 +Y+G Sbjct: 303 IYSGSE 308 >UniRef50_B5YJZ4 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=B5YJZ4_THEYD Length = 311 Score = 430 bits (1107), Expect = e-119, Method: Composition-based stats. Identities = 157/308 (50%), Positives = 218/308 (70%), Gaps = 1/308 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 N + I +R S LA+WQA++VKDKL +P L VE+ + T GD ILD PLAK+GGKGL Sbjct: 4 KRNKIVIGSRGSKLAMWQANWVKDKLQTLYPELKVEIEKIKTTGDKILDAPLAKIGGKGL 63 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKE+E ALL R D+AVHSMKDVP E P+GL + ICEREDPRDAF+S + L+ LP Sbjct: 64 FVKEIEEALLSKRVDLAVHSMKDVPTEIPEGLQISAICEREDPRDAFISKDGVLLNELPQ 123 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 +++GTSSLRR QL R DL+I+ LRGNV TR+ KL +GE+ AI+LA+AG+KR+G+E+ Sbjct: 124 EAVLGTSSLRRTVQLKALRNDLVIKPLRGNVDTRIRKLKDGEFQAIVLAMAGVKRMGVEN 183 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + A ++ +PA+GQGA+GIE R+DD EL+ LNH ETA+ + AERA + + GG Sbjct: 184 LVTQAFSEDLMIPAIGQGAIGIETRVDDDFVNELIKPLNHEETAICILAERAFLSVMGGG 243 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQ-IIRGERRGAPQDAEQMGISLAEELLNNGAR 300 CQVP+ +A +++ + + ++G P+G +I+G R G+ A+ +G+ LA ELL+ G + Sbjct: 244 CQVPLACHARIVNNSLKIVGMIGDPEGKMPVIKGFREGSLSQAQSLGVELANELLHRGGK 303 Query: 301 EILAEVYN 308 EIL +VY Sbjct: 304 EILEKVYK 311 >UniRef50_C0Q9U2 HemC n=2 Tax=Bacteria RepID=C0Q9U2_DESAH Length = 325 Score = 429 bits (1103), Expect = e-119, Method: Composition-based stats. Identities = 146/307 (47%), Positives = 199/307 (64%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + ++I TR S LALWQA++VKD++ P VE++ + T GD+I+D PL+ VGGKGL Sbjct: 19 MKKTIKIGTRGSKLALWQANHVKDRIEDQFPETEVEIMTIKTTGDMIVDRPLSMVGGKGL 78 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKE+E ALLE+ D+AVHSMKD+P E P GL + + RE+P D +SNN SL LP Sbjct: 79 FVKEIEKALLESTIDMAVHSMKDMPGELPPGLVIGAVPARENPFDVLISNNNLSLADLPK 138 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ +GTSSLRR Q+ RPD+ S+RGN+ TRL KL GE+DA +LA AGL RLG+++ Sbjct: 139 GARIGTSSLRRASQIKHARPDIETASIRGNLDTRLKKLAAGEFDATLLAAAGLIRLGMKT 198 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 I I +PAVGQGA+ IE R +D +LA LNH ET V+ ERA RL+G Sbjct: 199 VITQYFDETIMIPAVGQGALCIESRQEDLDIAPVLAFLNHGETHTVVSGERAFLRRLDGS 258 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 C +P+ + L D + L LV + DG I++ G P+D ++ GI+LAE LL+ GA + Sbjct: 259 CHIPVACFGRLEDHRVILTGLVASEDGRTILKETVAGTPEDPQKAGIALAETLLSKGADK 318 Query: 302 ILAEVYN 308 IL + + Sbjct: 319 ILENLNS 325 >UniRef50_Q8YVU6 Porphobilinogen deaminase n=50 Tax=cellular organisms RepID=HEM3_ANASP Length = 323 Score = 424 bits (1090), Expect = e-117, Method: Composition-based stats. Identities = 151/309 (48%), Positives = 199/309 (64%), Gaps = 3/309 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +RI +R+S LAL Q ++V+++L S P + E+ M T+GD ILD LAK+G KGLF Sbjct: 10 RTIRIGSRKSQLALVQTYWVREQLQNSFPDINFEVHTMSTQGDKILDVALAKIGDKGLFT 69 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALP 120 KELEV ++ D AVHS+KD+P P+GL L I ERE+P DA V + +D LP Sbjct: 70 KELEVGMINEEIDFAVHSLKDLPTNLPEGLALAAITERENPADALVVHENFKDKQIDTLP 129 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 AG+++GTSSLRR QL + P L + +RGN+ TRL+KLD GEYD +ILA AGL+RLG+ Sbjct: 130 AGAVIGTSSLRRLAQLRNQFPHLTFKDVRGNLNTRLAKLDAGEYDGLILAAAGLQRLGMG 189 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R+ LP EISL AVGQGA+GIECR DD+ +L A+ H ET R AER+ LEG Sbjct: 190 DRVHQILPKEISLHAVGQGALGIECRADDAELITVLKAIEHPETRDRCLAERSFLRSLEG 249 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPIG E+ E+ L +V + DG +++ G DAE +GI LAE L GA+ Sbjct: 250 GCQVPIGVNTEINGNELILTGVVASVDGQNLVKDTVSGNASDAEAIGIRLAELLREQGAQ 309 Query: 301 EILAEVYNG 309 EIL ++ Sbjct: 310 EILNTIFAE 318 >UniRef50_D1BNZ5 Porphobilinogen deaminase n=3 Tax=Veillonella RepID=D1BNZ5_VEIPT Length = 312 Score = 423 bits (1088), Expect = e-117, Method: Composition-based stats. Identities = 144/309 (46%), Positives = 195/309 (63%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + + +RI TR+S LALWQA ++ +L +P + VELV T+GD IL+ PLA+VGGKGL Sbjct: 1 MRDHIRIGTRKSALALWQAEHISAELQRLYPNITVELVHFNTKGDRILEKPLAQVGGKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F ELE A+ DIAVHS+KD+P E P+GL L I RE P DA VS Y +LD LP Sbjct: 61 FTAELEEAMHAGDIDIAVHSLKDMPTELPEGLTLGAISAREVPYDALVSPVYKTLDKLPQ 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ VGTSSLRRQ QL RPDL + +RGNV TRLSK++ + D +ILA AGLKRLGLE Sbjct: 121 GARVGTSSLRRQAQLLHVRPDLKVEVIRGNVQTRLSKIETEKLDGVILAQAGLKRLGLED 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 +I + +PAVGQGA+ IECR DD+ ++L +N T V ER+ +L GG Sbjct: 181 QITQVFKADEMIPAVGQGALAIECRADDTEMLDMLDPINDEATRYAVEGERSFLRQLNGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 CQVP+G + + G++ L+A++ + DG + GE G + E +G +LA+ L G + Sbjct: 241 CQVPMGVHGTINKGQLTLKAMIASLDGKTVYEGEISGPAKKGEILGKNLAKALYEEGGKR 300 Query: 302 ILAEVYNGD 310 I+ + Sbjct: 301 IVDALIEEG 309 >UniRef50_Q8DIE4 Porphobilinogen deaminase n=11 Tax=cellular organisms RepID=HEM3_THEEB Length = 320 Score = 418 bits (1075), Expect = e-115, Method: Composition-based stats. Identities = 151/314 (48%), Positives = 199/314 (63%), Gaps = 3/314 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 +RI +R+S LAL Q +V+ +L H E+V M T+GD ILD LAK+G KGL Sbjct: 5 SSRPVRIGSRKSQLALVQTEWVQAQLQTHHRDRAFEVVTMTTQGDNILDVALAKIGDKGL 64 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDA 118 F KELE+++L D+AVHS+KD+P + P GL L I EREDP DA V ++D Sbjct: 65 FTKELELSMLRGETDLAVHSLKDLPTQLPDGLVLAAITEREDPADALVLGAKWTGHTIDT 124 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 LP G+++GTSSLRR QL P L + +RGN+ TRL+KLD GEYDA+ILAVAGL+RLG Sbjct: 125 LPEGTVIGTSSLRRLAQLRHYYPHLTFKDVRGNLNTRLAKLDAGEYDALILAVAGLRRLG 184 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 RI LP +SL AVGQGA+GIECR +D+ L+ L H ET R AERA +L Sbjct: 185 FGDRISQVLPATVSLYAVGQGALGIECRAEDADILALVKTLEHPETTARCLAERAFLRQL 244 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 EGGCQVPIG + + +G++ L LV + DG ++++ G AE++G LA +L G Sbjct: 245 EGGCQVPIGVHTVIENGQLTLTGLVASLDGQRLVKDSLTGDVATAEELGTRLALKLREQG 304 Query: 299 AREILAEVYNGDAP 312 A EIL E++ P Sbjct: 305 ASEILEEIFATVRP 318 >UniRef50_Q65GK1 Porphobilinogen deaminase n=98 Tax=Bacillales RepID=HEM3_BACLD Length = 313 Score = 414 bits (1066), Expect = e-114, Method: Composition-based stats. Identities = 143/308 (46%), Positives = 188/308 (61%), Gaps = 4/308 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 + + +R+S LA+ Q +V KL +P E+ +VT+GD ILD L+KVGGKGLFV Sbjct: 2 RNIIVGSRRSKLAMTQTKWVIKKLEELNPDFTFEIKEIVTKGDRILDVTLSKVGGKGLFV 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE+E A+L D+AVHSMKD+P P+GL + I +RED RD +S L L G+ Sbjct: 62 KEIEQAMLSGEIDMAVHSMKDMPSVLPEGLMVGCIPKREDARDVLISKGRQKLADLKQGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL-ESR 182 +VGTSSLRR QL + RPDL I+ +RGN+ TRL KL+ +YDAIILA AGL R+G + Sbjct: 122 VVGTSSLRRSAQLLQMRPDLEIKWIRGNIDTRLKKLETEDYDAIILAAAGLSRMGWKDDV 181 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 + L PE LPAVGQGA+ IECR D L + LN T L VTAERA +EGGC Sbjct: 182 VTEFLDPESCLPAVGQGALAIECRGSDEELLSLFSRLNDRYTQLTVTAERAFLHAMEGGC 241 Query: 243 QVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 QVPI +A++ DG I L LV +PDG + R +G +D E +G A + GA+ Sbjct: 242 QVPIAGFAKMDEDGVIELTGLVASPDGKTVYRETVKG--KDPEAVGRECAAVMSEKGAKA 299 Query: 302 ILAEVYNG 309 ++ V Sbjct: 300 LIDRVKQE 307 >UniRef50_Q0I178 Porphobilinogen deaminase n=45 Tax=Bacteria RepID=HEM3_HAES1 Length = 321 Score = 414 bits (1064), Expect = e-114, Method: Composition-based stats. Identities = 200/320 (62%), Positives = 236/320 (73%), Gaps = 12/320 (3%) Query: 1 ML-DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGK 59 M + L+IATRQSPLALWQA+YVK++L + L VELVP++T+GDVILDTPLAK+GGK Sbjct: 1 MSINKTLKIATRQSPLALWQANYVKNRLQQRYSHLSVELVPIITKGDVILDTPLAKIGGK 60 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 GLFVKELE ALL ADIAVHSMKDVP++FP+GL L IC REDPRDAFVSN Y +LD L Sbjct: 61 GLFVKELENALLNGEADIAVHSMKDVPMQFPKGLELSVICPREDPRDAFVSNKYRTLDEL 120 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P G+IVGTSSLRRQCQL R DL IRSLRGNVGTRL+KLD G+YDAIILA AGL RLGL Sbjct: 121 PQGAIVGTSSLRRQCQLKNWRADLDIRSLRGNVGTRLNKLDQGDYDAIILASAGLIRLGL 180 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 RIR+ + + LPA GQGAVGIECR+DD + LL L T V AERAMN L+ Sbjct: 181 TERIRSFIEIDTILPACGQGAVGIECRVDDRDVQSLLMPLADQTTTYCVLAERAMNFHLQ 240 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER-----------RGAPQDAEQMGI 288 GGCQVPIG+YA L + +++LR LVG GSQI+ E + A Q AE++G+ Sbjct: 241 GGCQVPIGAYAILENNQLYLRGLVGDVHGSQILSAEGQFELSLDFESSQSAVQKAEELGV 300 Query: 289 SLAEELLNNGAREILAEVYN 308 S+AE+LL GA +IL VY Sbjct: 301 SIAEQLLQQGADKILQAVYQ 320 >UniRef50_A1AUE7 Porphobilinogen deaminase n=44 Tax=Bacteria RepID=HEM3_PELPD Length = 310 Score = 413 bits (1062), Expect = e-114, Method: Composition-based stats. Identities = 167/310 (53%), Positives = 204/310 (65%), Gaps = 1/310 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M LRI TR S LALWQA++VK +L +P + V L + T GD ILD PLA+VGGKG Sbjct: 1 MPPRQLRIGTRASQLALWQANWVKSELEKRYPAMEVTLTKIKTMGDRILDVPLAQVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E A+L DIAVHSMKDVP EFP+GLGL I EREDPRDA VS LP Sbjct: 61 LFVKEIEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVVSR-AARFSHLP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGTS+LRRQ QL RPDL + ++RGNV TR+ KLD DA+ILA AGLKRLGL Sbjct: 120 PGARVGTSALRRQAQLLHARPDLEMVTIRGNVETRIRKLDEENLDAVILAAAGLKRLGLT 179 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R+ L E S+PA+GQGA+GIECRL D E +A NH +T+ V AERA+ R +G Sbjct: 180 QRVAEYLDVEFSIPAIGQGALGIECRLSDPVVTEAIAFFNHPDTSHAVRAERALLRRCQG 239 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPI ++ + GE+ L L+ A DG + +R E G E +G LA+ LL+ G R Sbjct: 240 GCQVPIAAHGTIRGGELRLVGLIAAVDGREFVRDEISGPVDQCEHLGEELADRLLSRGGR 299 Query: 301 EILAEVYNGD 310 IL EVY + Sbjct: 300 AILEEVYQRE 309 >UniRef50_C9KL85 Hydroxymethylbilane synthase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KL85_9FIRM Length = 315 Score = 413 bits (1062), Expect = e-114, Method: Composition-based stats. Identities = 162/307 (52%), Positives = 201/307 (65%), Gaps = 1/307 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M ++ + I TR S LALWQA YV D L +P L VE M T+GD ILD PLAK+GGKG Sbjct: 1 MKNDTIVIGTRSSKLALWQADYVADCLRKRYPELRVEKKLMTTKGDKILDAPLAKIGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF KELE +L DIAVHS+KD+P E P+GL + I ER DP DA VS Y +L+ LP Sbjct: 61 LFTKELEQDMLAGGIDIAVHSLKDMPTEVPEGLVISAITERFDPGDAVVSPKYRTLENLP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGTSSLRR+ QL RPDL I LRGNV TRL KL+ +DAIILAVAGLKRLG Sbjct: 121 QGAKVGTSSLRRKAQLLHARPDLQISDLRGNVNTRLEKLEREHFDAIILAVAGLKRLGFA 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 RI LP E+ LPAVGQGA+ IE R +D R L+A LN T AERA R+EG Sbjct: 181 DRITEVLPREMVLPAVGQGALAIETRENDREVRNLIAFLNDEATVACARAERAFLARVEG 240 Query: 241 GCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GCQVP+G YA +G + + A++ + DG+++ R G+ +AE +G +LA++LL G Sbjct: 241 GCQVPVGVYAVPEAEGRLHVEAVIASLDGARLYRDAAVGSAAEAESLGTALADKLLAMGG 300 Query: 300 REILAEV 306 IL E+ Sbjct: 301 IAILHEI 307 >UniRef50_B5EBG8 Porphobilinogen deaminase n=166 Tax=Bacteria RepID=HEM3_GEOBB Length = 318 Score = 411 bits (1058), Expect = e-113, Method: Composition-based stats. Identities = 158/310 (50%), Positives = 205/310 (66%), Gaps = 1/310 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M LRI TR S LALWQA++VK +L +P + V L + T GD ILD PLA+VGGKG Sbjct: 1 MALKELRIGTRASQLALWQANWVKSELEKRYPDMTVTLTKIKTIGDKILDVPLAQVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E A+L DIAVHSMKDVP EFP+GLGL I EREDPRDA +SN LP Sbjct: 61 LFVKEIEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVISN-GVKFADLP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GTS+LRRQ QL + RPDL + +RGNV TR+ KL DA+ILA AGL RLG Sbjct: 120 QGARIGTSALRRQAQLLKVRPDLEMVIIRGNVQTRMDKLKTEGLDAVILAAAGLNRLGFA 179 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 +I LP ++SLPA+GQGA+GIEC L + ++ ++ N +T+ V AERA+ R EG Sbjct: 180 DQITEMLPTDLSLPAIGQGALGIECNLSNQDVKDAISFFNSPDTSRAVRAERALLWRCEG 239 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPI ++ E+ ++ L + + DG ++G G D E++G+ LAE+LL+ G Sbjct: 240 GCQVPIAAFGEVTGDQLKLTGFIASVDGKVSVKGVVTGPADDCEKLGVKLAEQLLSEGGH 299 Query: 301 EILAEVYNGD 310 ILAEVY + Sbjct: 300 AILAEVYQRE 309 >UniRef50_A6TJD5 Porphobilinogen deaminase n=2 Tax=Firmicutes RepID=HEM3_ALKMQ Length = 316 Score = 410 bits (1055), Expect = e-113, Method: Composition-based stats. Identities = 139/308 (45%), Positives = 191/308 (62%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 ++I +R S LAL QA + + L P E++ + T GD ILD L K+GGKGLFV Sbjct: 2 RTIKIGSRASQLALVQAEIIINMLKEKFPQYTYEIIKITTLGDRILDKTLDKIGGKGLFV 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE++ AL E + D+A+HSMKD+P E P+ L L I +REDPRD ++ SL+ LP G+ Sbjct: 62 KEIQKALAEEKIDLAIHSMKDMPGETPEELVLGAITKREDPRDVLITRENKSLEELPKGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 ++G+SSLRRQ Q+ R D+ + +RGNVGTRL K++ D +ILA AGL RLGL+ +I Sbjct: 122 VIGSSSLRRQAQVMALRGDIKVVPIRGNVGTRLGKIETESLDGVILAAAGLNRLGLKEKI 181 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + L E PAVGQGA+G E R D E+L A+NH ET V AERA LEGGC Sbjct: 182 SSYLEIEDFTPAVGQGALGCEARRKDIEMLEMLLAINHEETYRCVMAERAFLKLLEGGCH 241 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 VPIG+Y + E+ + +V + DG ++I+ + G D + +GI L E L+ GA+EIL Sbjct: 242 VPIGAYGQQQGQELHMTGMVASSDGRRVIKEQVMGDIADFQALGIQLGETLIEKGAKEIL 301 Query: 304 AEVYNGDA 311 V + Sbjct: 302 ETVNTDNR 309 >UniRef50_Q31PM2 Porphobilinogen deaminase n=8 Tax=cellular organisms RepID=HEM3_SYNE7 Length = 320 Score = 404 bits (1039), Expect = e-111, Method: Composition-based stats. Identities = 151/312 (48%), Positives = 200/312 (64%), Gaps = 3/312 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +RI +R+S LAL Q H+V+ +L +P ++ M T+GD+ILD LAK+G KGLF Sbjct: 7 RPIRIGSRKSQLALVQTHWVQGELQRLYPDRQFDVQTMSTQGDIILDVALAKIGDKGLFT 66 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALP 120 KELEVA+L D AVHS+KD+P P+GL L + EREDP DA V + L+ LP Sbjct: 67 KELEVAMLAGEVDFAVHSLKDLPTRLPEGLILGCVTEREDPADALVVHDRFKDHQLETLP 126 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+++GTSSLRR QL P L + +RGN+ TRL+KLD GEYDA+ILA AGL+RL + Sbjct: 127 EGTVIGTSSLRRLAQLRHHYPHLQFKDVRGNLNTRLAKLDAGEYDALILAAAGLQRLSMA 186 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 RI +P +SL AVGQGA+GIECR +D ELL AL H T+ R AERA LEG Sbjct: 187 DRIHQLIPAAVSLHAVGQGALGIECRAEDPEILELLKALEHEPTSQRCLAERAFLRELEG 246 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPIG + DG + L +V + DG +++R + G D E +G++LA +L GA+ Sbjct: 247 GCQVPIGVNTAIADGTLTLTGMVASLDGQRLLRDQVSGPTSDPEALGLALAAQLKAQGAK 306 Query: 301 EILAEVYNGDAP 312 EIL E++ P Sbjct: 307 EILDEIFATVRP 318 >UniRef50_C6HUG2 Porphobilinogen deaminase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HUG2_9BACT Length = 321 Score = 403 bits (1036), Expect = e-111, Method: Composition-based stats. Identities = 156/305 (51%), Positives = 205/305 (67%), Gaps = 2/305 (0%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + +RI TR S LALWQA +V + GL EL + T GD+IL PL++VGGKGLF Sbjct: 7 SSPIRIGTRGSELALWQARHVAAMIR-HTAGLESELTIIKTTGDMILSVPLSQVGGKGLF 65 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 VKE+E AL+ D+AVHSMKDVP P+GL + I REDPRDAFVSN Y S +LP G Sbjct: 66 VKEIEEALIAGTIDLAVHSMKDVPAFLPEGLEIGAILSREDPRDAFVSNAYSSFSSLPPG 125 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 + +GTSSLRR QL +RRPDL SLRGNVGTRL KLD + DAIILA AGL RLG R Sbjct: 126 ARIGTSSLRRMAQLKKRRPDLRFESLRGNVGTRLRKLDENQIDAIILAAAGLIRLGFSDR 185 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 IR LP E+SLPAVGQGA+G+ECR D R R +LA ++ ET V AER + + L+GGC Sbjct: 186 IREYLPVELSLPAVGQGALGLECRTGDHRIRTILARMHDPETTACVLAERGVLSALDGGC 245 Query: 243 QVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 Q+PI ++A + +I L A + +G+ ++ G ++A ++G+ A++LL+ G ++ Sbjct: 246 QLPIAAHARTISPEQIELIARILDVEGTTLLEEHTSGPAKEAHRLGVEAAQKLLSRGGQK 305 Query: 302 ILAEV 306 IL ++ Sbjct: 306 ILTDI 310 >UniRef50_Q2RJ26 Porphobilinogen deaminase n=5 Tax=Clostridia RepID=HEM3_MOOTA Length = 313 Score = 400 bits (1028), Expect = e-110, Method: Composition-based stats. Identities = 150/305 (49%), Positives = 193/305 (63%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +++ +R+S LA WQA +V L + PGL LV + T+GD ILD LA++G KGLF KE Sbjct: 4 IKVGSRESELARWQARWVIQALEKAWPGLSCRLVTLKTKGDKILDVALARIGDKGLFTKE 63 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE+ALL+ D+AVHSMKD+P P+GL + I REDP D VS +L LP + V Sbjct: 64 LELALLDGAIDLAVHSMKDMPTTLPEGLVIGAIGPREDPADVLVSPEGYTLATLPIKARV 123 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR+ QLA RPDL + LRGNV TRL+K++ AI+LA AGLKRL + Sbjct: 124 GTSSLRRKAQLAYARPDLELVDLRGNVPTRLAKMERDGLTAIVLAAAGLKRLNHGQVLGE 183 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 +P I LPAVGQGA+G+E R D R EL+AA+NH TA V AERA LEGGCQVP Sbjct: 184 PIPYHICLPAVGQGAIGVEIRAGDRRVAELVAAINHPPTAAAVRAERAYLRALEGGCQVP 243 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 I + A + D + L+ +V + DG +++R G+ +D E G LA +LL GA EIL E Sbjct: 244 IAALATVEDTALVLQGMVASLDGREMLRDIASGSTRDPEAAGRELARKLLARGAGEILQE 303 Query: 306 VYNGD 310 V Sbjct: 304 VKAQS 308 >UniRef50_P08397 Porphobilinogen deaminase n=59 Tax=Chordata RepID=HEM3_HUMAN Length = 361 Score = 397 bits (1022), Expect = e-109, Method: Composition-based stats. Identities = 145/340 (42%), Positives = 192/340 (56%), Gaps = 33/340 (9%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 V+R+ TR+S LA Q V L AS+PGL E++ M T GD ILDT L+K+G K LF Sbjct: 19 RVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFT 78 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALP 120 KELE AL +N D+ VHS+KD+P P G + IC+RE+P DA V + +L+ LP Sbjct: 79 KELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLP 138 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGL 179 S+VGTSSLRR QL + P L RS+RGN+ TRL KLD E+ AIILA AGL+R+G Sbjct: 139 EKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQEFSAIILATAGLQRMGW 198 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 +R+ L PE + AVGQGA+G+E R D +L+ L+ ET LR AERA LE Sbjct: 199 HNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLE 258 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-----------GAPQD------ 282 GGC VP+ + + DG+++L V + DGS I+ + G D Sbjct: 259 GGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIHVPAQHEDGPEDDPQLVGI 318 Query: 283 ------------AEQMGISLAEELLNNGAREILAEVYNGD 310 A+ +GISLA LL+ GA+ IL + Sbjct: 319 TARNIPRGPQLAAQNLGISLANLLLSKGAKNILDVARQLN 358 >UniRef50_Q5ZRY6 Porphobilinogen deaminase n=6 Tax=Legionella RepID=HEM3_LEGPH Length = 309 Score = 397 bits (1021), Expect = e-109, Method: Composition-based stats. Identities = 153/309 (49%), Positives = 205/309 (66%), Gaps = 1/309 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M ++RIATRQSPLALWQA++V++ L+ P L +EL+PM+T GD L L GGKG Sbjct: 1 MSAKIIRIATRQSPLALWQANHVREMLVKQWPNLSIELLPMITSGDRFLKDKLLSAGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKELE ALL+ RAD+AVHS KD+P + P GL L IC+R++P DA +S + SL ALP Sbjct: 61 LFVKELEEALLDKRADLAVHSTKDMPAQLPDGLLLTAICKRDNPFDALISPQFKSLAALP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 +I+GTSSLRRQ QL P+L I++LRGN+ TRLSKL++GEY AIILA AGL+R+GL Sbjct: 121 KNAIIGTSSLRRQSQLLAYNPNLQIKTLRGNIHTRLSKLESGEYQAIILAAAGLERMGLA 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 I +P +I LP QGA+ IECR DD +EL+ LN +AL V ER +N +L G Sbjct: 181 HHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELVHGLNDPISALCVHTERRVNAKLGG 240 Query: 241 GCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 C +P Y + + + + LRA V DGSQ+I E++G +AE + E L+ GA Sbjct: 241 NCHIPFAVYCTITEEKLLLLRAKVLNMDGSQMIDDEQQGKIAEAEVIADRCTESLMTKGA 300 Query: 300 REILAEVYN 308 +L+ + + Sbjct: 301 MSLLSTIPS 309 >UniRef50_Q30Y29 Porphobilinogen deaminase n=13 Tax=Bacteria RepID=HEM3_DESDG Length = 316 Score = 394 bits (1013), Expect = e-108, Method: Composition-based stats. Identities = 163/309 (52%), Positives = 206/309 (66%), Gaps = 2/309 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPG-LVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + IATR S LALWQA ++K+++M +P VEL+ + T+GD+ILD PLAKVGGKGLF Sbjct: 2 KKIVIATRGSKLALWQAEHIKERIMQQYPDSFEVELLVLKTKGDIILDVPLAKVGGKGLF 61 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 VKE+E ALL+ RADIAVHSMKDVP+E PQGL L I ERE P D+ +S YD LDALP G Sbjct: 62 VKEIEEALLDGRADIAVHSMKDVPMELPQGLTLGAIPEREVPTDSLLSARYDGLDALPQG 121 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 ++VGTSSLRRQ Q+ RPDL ++ LRGNV TR+ KL +GEYDAII+A +GLKRLG + Sbjct: 122 AVVGTSSLRRQSQILAMRPDLEVKWLRGNVQTRIRKLMDGEYDAIIMATSGLKRLGETAP 181 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 + L P + +PAVGQGA+G+E R D E+LA L+H + + V AER L+GGC Sbjct: 182 FHSELGPPLFMPAVGQGALGLEYRSDRQDLAEMLAFLDHRPSRICVEAERGFLFGLQGGC 241 Query: 243 QVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 QVPI YA + L LV DG+ +IR G DA G++LA ++ GA Sbjct: 242 QVPIAGYAVMTGDNSFELTGLVAELDGTAVIRRTAAGTEADARDTGLTLAAQVKAAGADA 301 Query: 302 ILAEVYNGD 310 IL VY Sbjct: 302 ILQRVYENG 310 >UniRef50_B2A1G7 Porphobilinogen deaminase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=HEM3_NATTJ Length = 311 Score = 394 bits (1012), Expect = e-108, Method: Composition-based stats. Identities = 137/310 (44%), Positives = 195/310 (62%), Gaps = 5/310 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR+S LAL Q ++V ++L +P + +E+ + T+GD +L+ L+KVGGKGLF+K Sbjct: 2 KLRIGTRRSQLALDQTNWVVEQLKTHYPDIEIEIKKIETKGDQLLNVSLSKVGGKGLFLK 61 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E++ ALL+ D+AVHSMKD+P E + L + I +R DP DA +SNN ++D LP + Sbjct: 62 EIQNALLQGEIDLAVHSMKDIPTETTEDLEICAITKRVDPLDALISNNDITIDELPENAK 121 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESRI 183 +GTSSLRR QL R DL I +RGN+ TR++KL E DA++LA AGL R G+ I Sbjct: 122 IGTSSLRRGSQLKAYRNDLQIIPIRGNINTRMNKLQELPELDAVVLAKAGLVRSGMTDSI 181 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + PEI +P GQGA+G+E R D+ +E LA L+ E+ + AERA RL G C Sbjct: 182 SQNISPEIIVPCPGQGALGLEIRHDNENLKEKLAVLDDSESRKAIGAERAFLNRLGGSCH 241 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD----AEQMGISLAEELLNNGA 299 VP+G+YAE+I E+ L +V + DG +I+ + D +G LAEEL+ GA Sbjct: 242 VPVGAYAEIISNELHLTGVVASEDGQDVIKRSVQTHLSDNNKIPSTLGNDLAEELIELGA 301 Query: 300 REILAEVYNG 309 +IL+E+ G Sbjct: 302 NKILSELKEG 311 >UniRef50_Q4L709 Porphobilinogen deaminase n=88 Tax=Bacillales RepID=HEM3_STAHJ Length = 310 Score = 393 bits (1010), Expect = e-108, Method: Composition-based stats. Identities = 139/310 (44%), Positives = 196/310 (63%), Gaps = 4/310 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L + +R+S LAL Q+ DKL A P L +E+ +VT+GD I++ L+KVGGKGLFV Sbjct: 2 RKLVVGSRRSKLALTQSQQFIDKLKAVDPTLEIEIKEIVTKGDRIVNKQLSKVGGKGLFV 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE++ L + D+A+HS+KDVP P+GL L I +RE P DA++S N+ L+ LP GS Sbjct: 62 KEIQQELFDKEIDMAIHSLKDVPSIIPEGLTLGCIPDREVPFDAYISKNHIPLNELPDGS 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 I+GTSSLRR Q+ + P+L I+ +RGN+ TRL KL+ +YDAIILA AGL+R+G I Sbjct: 122 IIGTSSLRRGAQILSKYPNLEIKWIRGNIDTRLKKLEIEDYDAIILAAAGLRRMGWSDDI 181 Query: 184 -RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 L +I LPA+GQGA+GIECR DD ELL+ +++ A VTAER + ++G C Sbjct: 182 VTTYLDKDILLPAIGQGALGIECRSDDVELLELLSKVHNQAVANCVTAERTFLSAMDGSC 241 Query: 243 QVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 QVPIG YA +GEI L+ PDG++ G ++ +G +++ L GA E Sbjct: 242 QVPIGGYATNKENGEIEFTGLIMTPDGTKRYEHTEVG--KNPVDLGEAVSRVLKEQGAYE 299 Query: 302 ILAEVYNGDA 311 I+ ++ A Sbjct: 300 IIKKLNEEQA 309 >UniRef50_B3E2H7 Porphobilinogen deaminase n=3 Tax=Proteobacteria RepID=HEM3_GEOLS Length = 312 Score = 392 bits (1007), Expect = e-107, Method: Composition-based stats. Identities = 161/310 (51%), Positives = 207/310 (66%), Gaps = 1/310 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M LRI TR S LALWQA++ K +L A +PG+ VELV + T GD ILD PLA+VGGKG Sbjct: 1 MAPKRLRIGTRASQLALWQANWTKSELEARYPGIQVELVKIKTMGDKILDVPLAQVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E A+L D+AVHSMKDVP EFP+GLGLV +REDPRDAF+S + + L Sbjct: 61 LFVKEIEEAMLRGEIDLAVHSMKDVPTEFPEGLGLVVTTKREDPRDAFIS-DKVTFSELR 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GTS+LRRQ QL + RPDL + +RGNV TR+ KL DA+ILA AGL RLG Sbjct: 120 QGARIGTSALRRQAQLLKARPDLEMVIIRGNVETRIRKLKEDNLDAVILAAAGLNRLGFT 179 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 + L + S+PA+GQGA+G+ECRLDD+ T E LA LNH +TA V AERA+ R EG Sbjct: 180 DVVTELLDTDFSIPAIGQGALGLECRLDDNATIEALAFLNHADTAAAVAAERALLKRCEG 239 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPI ++ + + L + + DG Q +R G+ DA ++G LA+ LL G + Sbjct: 240 GCQVPIAAHGTVSGDTLTLVGFIASVDGKQTVRDRISGSTADAVKLGTELADRLLAAGGK 299 Query: 301 EILAEVYNGD 310 IL +VY + Sbjct: 300 AILEDVYQRE 309 >UniRef50_C9R7U0 Porphobilinogen deaminase n=1 Tax=Ammonifex degensii KC4 RepID=C9R7U0_AMMDK Length = 308 Score = 389 bits (1001), Expect = e-107, Method: Composition-based stats. Identities = 144/305 (47%), Positives = 186/305 (60%), Gaps = 3/305 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 LRI TR S LAL Q V L P E+V + T GD + + L ++GGKGL Sbjct: 4 SKRCLRIGTRGSDLALAQTEQVLQILRERWPHYTYEIVKIKTTGDKVRNLALPRIGGKGL 63 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F KELEVALLE + D+AVHS+KD+P E P+ L + + RE P D +S L+ LP Sbjct: 64 FTKELEVALLEEKIDLAVHSLKDLPTELPEELCVGAVLPREHPGDVLISLTGAGLEDLPE 123 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLK--RLGL 179 G+ +GTSSLRRQ QL RPDL LRGNV TRL KL+ GE +A++LA AGL+ RL L Sbjct: 124 GARIGTSSLRRQAQLKAARPDLNFVPLRGNVPTRLRKLEKGECEAVVLAWAGLRRLRLDL 183 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 R+ LP ++ LPAV QGA+G+E R +D R+++ L+ T L VTAERA L Sbjct: 184 TGRMT-LLPYQVCLPAVAQGAIGVEMRKEDRELRKMVEVLDDPTTRLEVTAERAFLRWLG 242 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GGC VPI + A + EI L LV P+G +I+RG+ G+ E++GI LAE LL GA Sbjct: 243 GGCHVPIAALARVAGAEILLEGLVADPEGKRIVRGQESGSTAYPEEVGIRLAERLLREGA 302 Query: 300 REILA 304 E+L Sbjct: 303 EELLR 307 >UniRef50_B3QWI1 Porphobilinogen deaminase n=12 Tax=Chlorobiaceae RepID=HEM3_CHLT3 Length = 314 Score = 388 bits (998), Expect = e-106, Method: Composition-based stats. Identities = 144/314 (45%), Positives = 195/314 (62%), Gaps = 4/314 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + L I TR SPLALWQA ++K +L +P L + L + T GD ILD PLAK+G KGL Sbjct: 1 MKKALIIGTRSSPLALWQAEFIKAELSKHYPSLDISLRHIKTTGDKILDAPLAKIGDKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F +E+E +L N D+AVHS+KD+P E P+GL + I ERED RD +S +L LP Sbjct: 61 FTREIEHVMLRNEIDLAVHSLKDLPTETPEGLVITAITEREDNRDVLISKGKYTLKTLPQ 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+IV TSSLRR+ QL RPDL + +RGN+ TR + + G+ +A++LA AG+ RL Sbjct: 121 GAIVATSSLRRRSQLLHLRPDLEVIDMRGNLNTRFKRFEEGDAEAMLLAFAGVHRLEFSE 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 I + + LPAVGQGA+GIE R+DD TRELL LNH ET L ER++ LEGG Sbjct: 181 HIAEIISFDDILPAVGQGALGIETRIDDEETRELLKVLNHAETELCTKCERSLLRTLEGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR----GAPQDAEQMGISLAEELLNN 297 CQ+PIG++A + +G VG+ DG + I+ ++AEQ+GI +A+ Sbjct: 241 CQIPIGAHARIENGTFHFATYVGSIDGKRAIKKSLSRENVTTVEEAEQIGIEVADAARAA 300 Query: 298 GAREILAEVYNGDA 311 GA EIL E+ +A Sbjct: 301 GANEILCEIRTDNA 314 >UniRef50_Q54P93 Porphobilinogen deaminase n=1 Tax=Dictyostelium discoideum RepID=HEM3_DICDI Length = 325 Score = 387 bits (996), Expect = e-106, Method: Composition-based stats. Identities = 132/317 (41%), Positives = 191/317 (60%), Gaps = 12/317 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 + I +R+S LA+ Q +V+D++ +PG++VE+ M T GD +LD L+K+G KGLF K Sbjct: 9 KVIIGSRKSQLAMLQTEWVRDRIQELNPGIIVEIKTMDTTGDKVLDVSLSKIGDKGLFTK 68 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN-----NYDSLDAL 119 ELE +L D+AVHS+KD+P + P GL L I +R + DAF++N L L Sbjct: 69 ELEDMMLNGTIDLAVHSLKDIPTKLPDGLKLGAITKRYNTSDAFIANAKKHGKNCKLSEL 128 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--DNGEYDAIILAVAGLKRL 177 P G+++G+SSLRR QL + P L + +RGN+ TR KL D+ YD +ILAVAGL+R+ Sbjct: 129 PQGAMIGSSSLRRVAQLKKAYPHLQFKDIRGNLNTRFKKLEDDSNGYDGMILAVAGLERM 188 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 L I +P ISL AVGQG++GIEC+ D + +L L H E+ AER+M Sbjct: 189 ELTDHISEIIPDSISLYAVGQGSLGIECKDGDDFIQSILNPLIHRESMYCCEAERSMLRD 248 Query: 238 LEGGCQVPIGSYAELI-----DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAE 292 LEGGC VPIG +L D + + A+V DGS+ I + G Q+G S+A+ Sbjct: 249 LEGGCHVPIGVVTKLHNQSQPDETLEINAIVLNLDGSKYIESKIIGPSIQYYQLGKSIAQ 308 Query: 293 ELLNNGAREILAEVYNG 309 +L+N G+++IL+E Sbjct: 309 DLINKGSKDILSEFIKK 325 >UniRef50_A6WXJ2 Porphobilinogen deaminase n=56 Tax=cellular organisms RepID=HEM3_OCHA4 Length = 314 Score = 386 bits (992), Expect = e-106, Method: Composition-based stats. Identities = 132/306 (43%), Positives = 174/306 (56%), Gaps = 2/306 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGG 58 + + L+I TR S LAL QA+ + +LM +H P +E++PM T GD I D L+++GG Sbjct: 6 LKNGTLKIGTRGSKLALAQAYETRRRLMEAHGLPEEAIEIIPMSTAGDRIQDRALSEIGG 65 Query: 59 KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118 KGLF +E+E AL + R D+AVHS KD+P P GL L EREDPRDAF+ L Sbjct: 66 KGLFTEEIEQALTDGRIDLAVHSTKDMPTVLPDGLHLSVFLEREDPRDAFIGRTASRLLD 125 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 LP G+ VG+SSLRRQ + RPD+ + RGNV TRL KL+ GE D LA AGL+RLG Sbjct: 126 LPQGATVGSSSLRRQALIRRLRPDIQVVIFRGNVDTRLRKLEAGEVDGTFLACAGLRRLG 185 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 L I PE PA GQGA+GIE R+ D+R LLA L H ET + + ERA L Sbjct: 186 LGDVITDLADPESFPPAPGQGAIGIETRIGDTRIDTLLAPLAHRETGIALACERAFLAAL 245 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 +G C+ PI A + + ++ PDGS+ + G +A +G AE L Sbjct: 246 DGSCRTPIAGLATVNGDTVSFHGMILKPDGSEAHEIKTEGPASNAAAIGTEAAEHLRAKA 305 Query: 299 AREILA 304 + Sbjct: 306 GPQFFE 311 >UniRef50_Q2LQU2 Porphobilinogen deaminase n=1 Tax=Syntrophus aciditrophicus SB RepID=HEM3_SYNAS Length = 306 Score = 385 bits (991), Expect = e-106, Method: Composition-based stats. Identities = 131/305 (42%), Positives = 186/305 (60%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 ++I TR S LAL Q + +L +P + +E+V + T GD+ D PLAK+GGKGLF+KE Sbjct: 1 MKIGTRGSALALTQTRQIAARLQGQYPEMHLEIVVIKTSGDIQKDVPLAKIGGKGLFIKE 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E ALL D+AVHSMKD+P E P+GL + + REDPRD +S D LPAG+ + Sbjct: 61 IEEALLAGTVDLAVHSMKDLPAELPEGLQIAAVPRREDPRDVLISGICREFDNLPAGARI 120 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT SLRR QL + RPDL I LRGN+ TR+ K+ D +++A AG++R+G ++ Sbjct: 121 GTGSLRRSVQLRDWRPDLEIVPLRGNLDTRIRKVAQAALDGVVVAAAGIRRMGWAEKVTQ 180 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 +P E LPAVGQG + +E R +D + LA L T VTAERA RL GGC +P Sbjct: 181 FIPTEKMLPAVGQGVLCLETREEDEDLKAGLAFLEDKRTRREVTAERAFLRRLGGGCTLP 240 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 + ++AE + +R +VG+ + +IR E G+ + A +G LAE LL+ G R +L Sbjct: 241 VAAFAEQRGDVLTIRGMVGSLNERTMIRQEIYGSVEQAVDLGTELAERLLDGGGRILLEH 300 Query: 306 VYNGD 310 + +G Sbjct: 301 LEDGQ 305 >UniRef50_A7NKU8 Porphobilinogen deaminase n=5 Tax=Bacteria RepID=HEM3_ROSCS Length = 303 Score = 384 bits (987), Expect = e-105, Method: Composition-based stats. Identities = 152/303 (50%), Positives = 195/303 (64%), Gaps = 1/303 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + N L I TR S LAL Q H ++D L A+HPGL V + + TRGD+ILD PL +G KGL Sbjct: 1 MRNSLTIGTRASKLALVQTHMIRDALQAAHPGLTVAVERITTRGDIILDRPLNAIGDKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FV E+E A+ R D+AVHS KD+P P + L R DPRDA V+ +L +LP Sbjct: 61 FVVEIEEAMRAGRVDLAVHSAKDLPSTLPPDMTLAVCPRRADPRDALVAQPGMTLASLPH 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ VGTSSLRR CQL RPDL + LRGNV TRL KL G+YDAI+LA AGLKRLGLE Sbjct: 121 GARVGTSSLRRACQLRALRPDLTLLDLRGNVDTRLRKLREGQYDAIVLAAAGLKRLGLEE 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 I L P++ +PAVGQG +G+E R D LLA L+ +TAERA R+ GG Sbjct: 181 VITELLEPDVLIPAVGQGIIGVEARAGDDEVLRLLAPLDDPAARAAITAERAFLARIGGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 C+VP+G+ A L E+ L ++GA DG +++RG R G+ D +G +LAEELL+ G + Sbjct: 241 CRVPVGALALLEGDELLLYGMIGALDG-RMVRGMRSGSASDPAGLGSALAEELLDAGGQA 299 Query: 302 ILA 304 +LA Sbjct: 300 LLA 302 >UniRef50_B2S842 Porphobilinogen deaminase n=38 Tax=Rhizobiales RepID=HEM3_BRUA1 Length = 314 Score = 384 bits (987), Expect = e-105, Method: Composition-based stats. Identities = 134/305 (43%), Positives = 170/305 (55%), Gaps = 2/305 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGK 59 + L+I TR S LAL QA+ + L +H P +E++PM T GD I D PL++VGGK Sbjct: 7 KNGTLKIGTRGSKLALAQAYLTRRLLQEAHGLPEDAIEILPMSTAGDRIQDRPLSEVGGK 66 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 GLF +E+E AL + R DIAVHS KD+P P+GL L EREDPRDAF+ + L Sbjct: 67 GLFTEEIEQALKDGRIDIAVHSTKDMPTALPEGLHLSVFLEREDPRDAFIGRSARRFMDL 126 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P G+ VG+SSLRRQ + RPD+ + RGNV TRL KLD GE D LA AGL+RLGL Sbjct: 127 PQGATVGSSSLRRQALIRRLRPDIEVVMYRGNVDTRLRKLDAGEVDGTFLACAGLRRLGL 186 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 I L P + PA GQGA+GIE R+ D R LLA L H ET + + ERA L+ Sbjct: 187 ADVITDVLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERAFLGALD 246 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 G C+ PI A + + R ++ PDG Q G DA +G A + Sbjct: 247 GSCRTPIAGLATVEGDRLSFRGMILTPDGRQAHEVTAEGVVSDAAALGTDAANRVRAMAG 306 Query: 300 REILA 304 Sbjct: 307 PHFFD 311 >UniRef50_A8PKX6 Porphobilinogen deaminase n=2 Tax=Gammaproteobacteria RepID=A8PKX6_9COXI Length = 311 Score = 383 bits (985), Expect = e-105, Method: Composition-based stats. Identities = 154/309 (49%), Positives = 194/309 (62%), Gaps = 3/309 (0%) Query: 1 MLDNV-LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGK 59 M LRIATR+SPLA WQA +K++L P L + L+P VT GD L + GGK Sbjct: 1 MSKKKFLRIATRKSPLAYWQATSIKNQLEKIFPFLKITLLPFVTEGDR-PSHSLNQWGGK 59 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 GLFVKELE ALL +ADIAVHS+KD+P+ +GL L IC+R DPRD +S + L Sbjct: 60 GLFVKELEAALLHGQADIAVHSLKDLPMTLEKGLVLGAICKRCDPRDVLISRSDRLFTQL 119 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P GS VGTSSLRRQ QL RPDL I LRGN+GTRL+KL GE+DAIILA AGL RL Sbjct: 120 PPGSYVGTSSLRRQSQLLALRPDLKIGVLRGNIGTRLNKLAAGEFDAIILAAAGLIRLKK 179 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 I + LPA GQGA+GIEC +D + ++AL H T V AERA++ L Sbjct: 180 TECISEYFEIDHFLPAPGQGALGIECHENDEESLTYISALIHPITHSCVLAERALSRELG 239 Query: 240 GGCQVPIGSY-AELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GGCQVP+ +Y A L I L+A VG+ DG+ I+ E++G +AE++G A++L G Sbjct: 240 GGCQVPLAAYAASLGQDFIRLQAFVGSSDGTTQIKVEKQGPRVEAEKIGFLAAQDLRALG 299 Query: 299 AREILAEVY 307 EIL + Sbjct: 300 VEEILNKFK 308 >UniRef50_Q1J288 Porphobilinogen deaminase n=5 Tax=Deinococci RepID=HEM3_DEIGD Length = 309 Score = 382 bits (981), Expect = e-104, Method: Composition-based stats. Identities = 130/306 (42%), Positives = 181/306 (59%), Gaps = 3/306 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILD--TPLAKVGGKGL 61 + + TR S LAL Q +V +L P + + T+GD LA+ G KG Sbjct: 2 RTVTVGTRGSALALAQTRWVVARLKEEWPDTDFRIQTISTKGDRDRAALQSLAQKGDKGF 61 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALP 120 +VKE+E ALL R DIAVHS+KD+P E P+GL + +I +R D RD + + L+ LP Sbjct: 62 WVKEIEDALLAGRIDIAVHSLKDLPTEQPEGLEIASIPKRVDARDVLIGKDGMKRLEDLP 121 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 +G+ VGTSS+RR+ L RPDL I LRGN+ TRL+ L +YDAI+LA AGL R + Sbjct: 122 SGARVGTSSVRRKAFLRAYRPDLQILDLRGNIDTRLAALGTPDYDAIVLAAAGLIRTEMR 181 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 RI + P++ LPA GQGA+ +E R DD + E++ A++ H T RVTAER L Sbjct: 182 HRIDEFIDPDLLLPAPGQGALALETRADDDLSIEVVYAIHDHATDDRVTAEREFLAGLGA 241 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GC P+G++A L DG + L VGA DGSQ+IR G P + +G LA ++L GA+ Sbjct: 242 GCMAPVGAHATLKDGVLTLEGWVGALDGSQVIRATTSGDPAECADLGAELAADMLGQGAQ 301 Query: 301 EILAEV 306 +++ Sbjct: 302 QLIEAA 307 >UniRef50_A3ETN3 Porphobilinogen deaminase n=2 Tax=Leptospirillum sp. Group II RepID=A3ETN3_9BACT Length = 314 Score = 382 bits (981), Expect = e-104, Method: Composition-based stats. Identities = 149/315 (47%), Positives = 191/315 (60%), Gaps = 5/315 (1%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 ML L+I +R S LALWQA +V + + G++ E+V + T GD+ILD L++VGGKG Sbjct: 1 MLPTPLKIGSRGSELALWQARHVASLIESVS-GVLPEIVVIKTTGDIILDRQLSEVGGKG 59 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E ALL D+AVHSMKDVP P GL L REDPRD F+S +Y + +LP Sbjct: 60 LFVKEIEEALLRKEIDLAVHSMKDVPAFLPPGLTLAATLTREDPRDVFLSPHYPDIKSLP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 + VGTSSLRR Q+ E R DL LRGNVGTR+ K++ G DAIILA AGL RLG Sbjct: 120 QKARVGTSSLRRLAQIREIRNDLEFIPLRGNVGTRIRKMEEGVVDAIILAGAGLLRLGHA 179 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 +R+R + P + LPA+GQGA+G+E R DD T L+ +L+ T L V AER + L G Sbjct: 180 NRVREWISPRVLLPAIGQGALGLEIRTDDETTGTLVRSLSDESTHLSVAAERGVLQSLNG 239 Query: 241 GCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERR---GAPQDAEQMGISLAEELLN 296 GCQVPI +YA + L V G++ I DA QMGI L LL+ Sbjct: 240 GCQVPIAAYAVWEKNRTLSLEGRVLDISGTRRIHARETRDIVTIDDAYQMGIDLGNRLLS 299 Query: 297 NGAREILAEVYNGDA 311 +GA EIL + + Sbjct: 300 DGAEEILNSILKKSS 314 >UniRef50_B6FXV9 Putative uncharacterized protein n=1 Tax=Clostridium hiranonis DSM 13275 RepID=B6FXV9_9CLOT Length = 299 Score = 381 bits (980), Expect = e-104, Method: Composition-based stats. Identities = 113/298 (37%), Positives = 175/298 (58%), Gaps = 1/298 (0%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +R+ TR S LAL Q ++ D+L P + E+ + T+GD IL L K+G KGLFVK Sbjct: 2 KIRVGTRGSNLALIQTNWAIDRLKEKFPEVEFEVKIIKTKGDKILHLSLDKIGDKGLFVK 61 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD-SLDALPAGS 123 E+E LLE D+AVHSMKD+P E +GL + +REDPRD + S D LP G+ Sbjct: 62 EIESQLLEGEIDLAVHSMKDMPAEVVEGLKFAAVPKREDPRDVIILREGLNSFDELPIGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +GT S RR+ QL +RPDL I +RGN+ TR+SK+++ D I+LA +G+ R LE +I Sbjct: 122 TIGTGSKRRKYQLLRKRPDLNIVPIRGNIETRISKIESENLDGIVLAASGVIRADLEEKI 181 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 LP ++ +PA QGA+ +E R +D +++ A+ + ++ AER+ ++G C Sbjct: 182 TEFLPVDLMIPAPAQGALALEIRENDEELEKMIDAIKDEISQIQTDAERSYLAGIDGSCH 241 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 +P+G+Y E+ ++ L + G DG +I G + +++G +LA+ +L E Sbjct: 242 IPMGAYCEVDGEKLTLTGIFGDEDGEKITVASLEGDRDNPKELGSNLAKLVLKKHREE 299 >UniRef50_Q180R9 Porphobilinogen deaminase n=11 Tax=Bacteria RepID=HEM3_CLOD6 Length = 301 Score = 380 bits (978), Expect = e-104, Method: Composition-based stats. Identities = 110/293 (37%), Positives = 172/293 (58%), Gaps = 1/293 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 + + TR S LAL Q +V ++L +P + E+ + T+GD+I + L K+G KGLFVKE Sbjct: 3 IVVGTRGSNLALIQTEWVINELKKKYPEISFEIKIIKTKGDLIQNVSLDKIGDKGLFVKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALPAGSI 124 +E LL+ + DIAVHSMKD+P GL +REDPRD + +LD LP G++ Sbjct: 63 IEQQLLDGKIDIAVHSMKDMPSYLANGLKFAHTPKREDPRDVLILREGYKNLDDLPHGAV 122 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GT S RR+ QL ++RPDL I +RGNV TR+ K+ + I+LA +G+ R L+ +I Sbjct: 123 IGTGSKRRKFQLLKQRPDLNIVQVRGNVETRIRKIKDENMHGIVLAASGIIRANLQDKIS 182 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 + LP ++ +PA QGA+ IE R +DS ++ +L T +++ AER + G C + Sbjct: 183 SYLPVDVVIPAPAQGALAIEIRSNDSAIEGIVNSLKDENTEIQILAERGFLDGVNGSCHI 242 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 P+ +Y E+I +I L L G +G +++ G ++G+ LA+ +L Sbjct: 243 PMAAYCEIIQDKIHLTGLYGDSEGKKVVIKSIDGDISSPRELGLKLAKLVLKE 295 >UniRef50_A7GYU4 Porphobilinogen deaminase n=34 Tax=Campylobacterales RepID=HEM3_CAMC5 Length = 311 Score = 379 bits (975), Expect = e-104, Method: Composition-based stats. Identities = 160/307 (52%), Positives = 200/307 (65%), Gaps = 3/307 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +L+IATR+S LALWQ+ ++K +LMA H GL VELV M T+GDVILDTPLAK+GGKGLF Sbjct: 2 KILKIATRKSALALWQSEHIKARLMAQHAGLQVELVGMKTKGDVILDTPLAKIGGKGLFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE ++L + IAVHS+KDVPV F GL L IC RED RDA +S Y D LP + Sbjct: 62 KELEDSMLSGQTHIAVHSLKDVPVAFLDGLVLAAICSREDVRDAMISQRYVKFDDLPQSA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGT+SLRR+ QL RPDL I SLRGNV TRL KL GE+DAIILA+AG+ RL L + Sbjct: 122 KVGTTSLRRKMQLLRMRPDLNIISLRGNVQTRLRKLKEGEFDAIILAMAGINRLNLADEV 181 Query: 184 RAALPPEI--SLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 P +I PA+GQGA+G+E +DD++ E + LN + + ER T LEGG Sbjct: 182 AHIYPFDIAQMTPAMGQGALGVEA-VDDAQILEKIKFLNDERSVIETRVERDFVTLLEGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 CQVPIG A L EI + A+VG PDGS++I + E +G LA E + GA+E Sbjct: 241 CQVPIGINARLASEEIEINAIVGLPDGSEVITENLTAKKSEFESVGKELAREFIARGAKE 300 Query: 302 ILAEVYN 308 +L Sbjct: 301 LLKRAEE 307 >UniRef50_A6Q7Y4 Porphobilinogen deaminase n=7 Tax=Epsilonproteobacteria RepID=HEM3_SULNB Length = 323 Score = 377 bits (968), Expect = e-103, Method: Composition-based stats. Identities = 136/309 (44%), Positives = 188/309 (60%), Gaps = 6/309 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L IATR S LALWQA+++K+++ + P + VEL + ++GD ILD PLA VGGKG F Sbjct: 2 EKLVIATRASNLALWQAYHIKERIETAFPEVRVELNEITSKGDKILDKPLALVGGKGHFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE ++ A +AVHS+KDVP P+GL L I ER+D D F+S+ Y SL LP G+ Sbjct: 62 KELEDEMIAGNAHLAVHSLKDVPTYIPEGLELCAITERQDQSDVFLSHTYKSLSELPEGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +VGT+SLRR+ QL E+RPDL ++ LRGNV TRL KL G+YDAIILA GL RL L I Sbjct: 122 VVGTTSLRRRMQLLEKRPDLKVKDLRGNVNTRLRKLKEGQYDAIILAYIGLYRLDLLKDI 181 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + +P +GQ A+GIE ++ R RE+ LNH T + ER + + GC Sbjct: 182 PYVEKLDFFIPPMGQAALGIEIVANNDRIREIAMTLNHEPTFICTKVERDFISVIGAGCS 241 Query: 244 VPIGSYAELIDGE------IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 P+ A + E I +RA++G PDG+ I+ +A+ +G LA+ ++ Sbjct: 242 APVAVNATMDKKEDDKVPTISVRAMIGYPDGTHILHKSLTVPLNEADILGDELAQAMIEE 301 Query: 298 GAREILAEV 306 GA +IL + Sbjct: 302 GALDILEQA 310 >UniRef50_D0LUE1 Porphobilinogen deaminase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LUE1_HALO1 Length = 320 Score = 377 bits (968), Expect = e-103, Method: Composition-based stats. Identities = 156/316 (49%), Positives = 196/316 (62%), Gaps = 11/316 (3%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M + + I+TR S LALWQAH+V+D++ P VELV + T+GD ILD PL+K+GGK Sbjct: 1 MSERTIHISTRGSQLALWQAHHVRDEIRRVRPAWQVELVIIKTQGDKILDVPLSKIGGKA 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E ALL+ RAD+AVHSMKDVP E GL + REDP DA + + LD L Sbjct: 61 LFVKEIEQALLDGRADVAVHSMKDVPAELAPGLFMAATSRREDPYDALCTRDGRGLDELA 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GTSSLRRQCQ+ RRPDL I LRGNV TRL KLD+G +DA+ILA AGLKRLG Sbjct: 121 EGATLGTSSLRRQCQILARRPDLRIEMLRGNVPTRLGKLDDGSFDAVILAAAGLKRLGHG 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDD-----SRTRELLAALNHHETALRVTAERAMN 235 RI L + +PAVGQG +GIE R D L AL+ RV AERAM Sbjct: 181 ERISQRLDGGVCVPAVGQGVLGIETRQGDAPADRELVEALREALHDPAEERRVVAERAMM 240 Query: 236 TRLEGGCQVPIGSYAELIDG------EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGIS 289 L G CQ P+ ++A + + L G PDGS+I+R + G +DA+ +G S Sbjct: 241 AALGGSCQTPLAAHASYRGDSDPVAGTLVIEGLCGRPDGSEILRAQVEGRAEDAQALGSS 300 Query: 290 LAEELLNNGAREILAE 305 LAEEL GA+ I+ Sbjct: 301 LAEELRGQGAQAIIDA 316 >UniRef50_Q43316 Porphobilinogen deaminase, chloroplastic n=61 Tax=cellular organisms RepID=HEM3_ARATH Length = 382 Score = 375 bits (965), Expect = e-103, Method: Composition-based stats. Identities = 137/309 (44%), Positives = 185/309 (59%), Gaps = 8/309 (2%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGL----VVELVPMVTRGDVILDTPLAKVGG 58 ++RI TR SPLAL QA+ ++KL HP L + + + T GD IL PLA +GG Sbjct: 72 TAIIRIGTRGSPLALAQAYETREKLKKKHPELVEDGAIHIEIIKTTGDKILSQPLADIGG 131 Query: 59 KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118 KGLF KE++ AL+ DIAVHSMKDVP P+ L RED RDAF+ +L Sbjct: 132 KGLFTKEIDEALINGHIDIAVHSMKDVPTYLPEKTILPCNLPREDVRDAFICLTAATLAE 191 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLII-RSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177 LPAGS+VGT+SLRR+ Q+ + P L + + RGNV TRLSKL G+ A +LA+AGLKRL Sbjct: 192 LPAGSVVGTASLRRKSQILHKYPALHVEENFRGNVQTRLSKLQGGKVQATLLALAGLKRL 251 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 + + + L + LPAV QGA+GI CR DD + LA+LNH ET L ++ ERA Sbjct: 252 SMTENVASILSLDEMLPAVAQGAIGIACRTDDDKMATYLASLNHEETRLAISCERAFLET 311 Query: 238 LEGGCQVPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGA--PQDAEQMGISLAEEL 294 L+G C+ PI YA + +G R LV +PDG++++ R+G +D +MG +EL Sbjct: 312 LDGSCRTPIAGYASKDEEGNCIFRGLVASPDGTKVLETSRKGPYVYEDMVKMGKDAGQEL 371 Query: 295 LNNGAREIL 303 L+ Sbjct: 372 LSRAGPGFF 380 >UniRef50_O94048 Porphobilinogen deaminase n=53 Tax=Saccharomyceta RepID=HEM3_CANAL Length = 340 Score = 373 bits (959), Expect = e-102, Method: Composition-based stats. Identities = 129/319 (40%), Positives = 185/319 (57%), Gaps = 17/319 (5%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 N ++I R+S LA+ Q+ VK + + P L ++ + T GD + PL GGK L+ Sbjct: 11 SNHVQIGGRKSKLAVVQSEIVKKVIEDTFPNLSCSILALSTLGDKVQTQPLYTFGGKSLW 70 Query: 63 VKELEVALLEN-----RADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---D 114 KELE+ LL++ + D+ VHS+KD+P P+ L I +REDPRDA V Sbjct: 71 TKELEILLLDSVDEFPKLDLIVHSLKDMPTNLPEEFELGCIFQREDPRDAIVMKQGSSYK 130 Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVA 172 SL LPAG+IVGTSS+RR QL + P L S+RGN+ TRL+KLD N EY +ILA A Sbjct: 131 SLKDLPAGAIVGTSSIRRSSQLIKNYPHLRFESVRGNIQTRLNKLDQPNNEYCCLILASA 190 Query: 173 GLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232 GL RLGL RI + L + AVGQGA+GIE R D + +L + + AER Sbjct: 191 GLIRLGLGHRITSYL--DDMYYAVGQGALGIEIRKGDDNIKSILKKIEDPIATICCLAER 248 Query: 233 AMNTRLEGGCQVPIGSYAELIDGE--IWLRALVGAPDGSQIIRGERRGAP---QDAEQMG 287 ++ LEGGC VP+G +++ + + + L+ ++ +PDG+ I E +D EQ+G Sbjct: 249 SLMRYLEGGCSVPLGVHSDYNESKQELTLKGIIVSPDGTVSIEDEVIKRITCDEDCEQVG 308 Query: 288 ISLAEELLNNGAREILAEV 306 I L ++L GA+EIL ++ Sbjct: 309 IELGDKLKAKGAKEILDKI 327 >UniRef50_Q8RFP5 Porphobilinogen deaminase n=16 Tax=Fusobacteriaceae RepID=HEM3_FUSNN Length = 298 Score = 373 bits (958), Expect = e-102, Method: Composition-based stats. Identities = 119/298 (39%), Positives = 166/298 (55%), Gaps = 5/298 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPL--AKVGGK 59 + + I +R S LAL QA+ VKD+L ++P L E+ +VT GD L + + + K Sbjct: 1 MKKNIIIGSRGSILALAQANLVKDRLQGNYPNLSFEIKEIVTSGDKDLKSNWENSDISLK 60 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 F KE+E LL+ DIAVHSMKD+P + L I +REDPRD VS N L L Sbjct: 61 SFFTKEIEQELLDGEIDIAVHSMKDMPAVSAKSLICGAIPDREDPRDVLVSKNGL-LVTL 119 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P G+ VGTSSLRR L RPD I+ LRGN+ TRL KL+ +YDAI+LA AGLKR GL Sbjct: 120 PQGAKVGTSSLRRAMNLKTVRPDFEIKHLRGNIHTRLKKLETEDYDAIVLAAAGLKRTGL 179 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 +I L E+ PA QG + I+CR +D +E+L ++++ A V ER + + Sbjct: 180 ADKITEYLNGEVFPPAPAQGVLYIQCRENDEEIKEILKSIHNEAIAKIVEIEREFSKIFD 239 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 GGC P+G Y+++ +I A+ D + IR +++ AEE+ N Sbjct: 240 GGCHTPMGCYSQVNGDKIKFTAVY--LDEGKQIRAVVEDDLAKGKEIAYMAAEEIKNK 295 >UniRef50_B3T8H9 Putative Porphobilinogen deaminase, dipyromethane cofactor binding domain protein n=1 Tax=uncultured marine microorganism HF4000_APKG5H11 RepID=B3T8H9_9ZZZZ Length = 322 Score = 372 bits (957), Expect = e-102, Method: Composition-based stats. Identities = 122/306 (39%), Positives = 171/306 (55%), Gaps = 1/306 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +++ +R S LAL Q H V ++L A+ P L E+ + TRGDV + LA +G G+FVKE Sbjct: 18 IKVGSRGSTLALIQDHVVINRLKANSPALEFEVDTVRTRGDVDQTSRLAGMG-LGIFVKE 76 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE LL+ + DIAVHS+KD+P + GL L + REDPRD V+ LD LP G+ + Sbjct: 77 LEQELLDGKLDIAVHSLKDMPTQLADGLVLGAVLSREDPRDVLVNRYGCPLDGLPKGAKI 136 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS RR QL + P + + S+RGNV TRL K E D ILA AG+ RLGL+ +I Sbjct: 137 GTSSPRRAAQLKQYAPQVEVVSIRGNVETRLRKAQGEEADGAILAAAGMIRLGLQDQIAE 196 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L +P GQG + +E R DD R ELL+A++ +T TAER RL GGC +P Sbjct: 197 YLSATQFVPPPGQGILAVEARADDFRMLELLSAIDDADTRYEATAERGFLARLGGGCSIP 256 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 +G+YA I + + DG + + +G +D Q+ L+ G +++A Sbjct: 257 VGAYARCNGDNIVMTIYMSTADGEKKFSAKIQGLKRDPLQLANDAYLALVERGGADLVAA 316 Query: 306 VYNGDA 311 A Sbjct: 317 ARANQA 322 >UniRef50_A8LIJ6 Porphobilinogen deaminase n=11 Tax=Alphaproteobacteria RepID=A8LIJ6_DINSH Length = 347 Score = 372 bits (956), Expect = e-102, Method: Composition-based stats. Identities = 144/304 (47%), Positives = 191/304 (62%), Gaps = 2/304 (0%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKG 60 D+ L+I TR S LAL QAH + +L A+ P E+V + T GD I D L+++GGKG Sbjct: 38 DSPLKIGTRGSLLALAQAHETRARLSAAFDLPEEAFEIVVIKTTGDRIQDRSLSEIGGKG 97 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF +E+E A+L+ DIAVHSMKD+PV+ P GL L T RED RDAFV+ + +L LP Sbjct: 98 LFTREIEDAMLDGSIDIAVHSMKDMPVDTPAGLALDTYLPREDVRDAFVTLDGGTLADLP 157 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G++VG+SSLRR+ QLA RRPDL + RGNV TR+ KL +G A LA+AGL RLG++ Sbjct: 158 EGAVVGSSSLRRRAQLAHRRPDLQLVEFRGNVQTRMKKLGDGVAHATFLAMAGLNRLGMD 217 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R+A+ PE LPAV QG +GIE R DD R E+LAA++ + R+ ERA + L+G Sbjct: 218 EVPRSAIAPEDMLPAVAQGCIGIERRADDPRAAEMLAAIHDGPSGHRLACERAYLSALDG 277 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 CQ PI AEL G I LRA + PDGS+++ +DA +MG +AE L Sbjct: 278 SCQTPIAGLAELDGGSIHLRAEILRPDGSEVLSDSETAPVEDAAKMGREVAERLRARAPD 337 Query: 301 EILA 304 + Sbjct: 338 GFFS 341 >UniRef50_D2R3S6 Porphobilinogen deaminase n=2 Tax=Planctomycetaceae RepID=D2R3S6_9PLAN Length = 311 Score = 372 bits (956), Expect = e-102, Method: Composition-based stats. Identities = 144/303 (47%), Positives = 192/303 (63%), Gaps = 2/303 (0%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LR+ TR SPLA WQA +V+D+L+A+ G+ VE++ + T GD PL ++GG+GLF K Sbjct: 6 KLRLGTRASPLARWQADWVRDQLIAA--GIDVEMILITTEGDQQTSQPLGQIGGQGLFTK 63 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E++ LL D+AVHS+KD+P GL L + ERED D + SL LP+G+ Sbjct: 64 EIQRRLLAGDIDLAVHSLKDLPTLPIDGLSLAAVPEREDTADILIGPAGTSLATLPSGAK 123 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GT SLRR+ QL R DL I +RGNV TRL KLD G+Y AIILA AGLKRL L+ R+ Sbjct: 124 IGTGSLRRKAQLLHARADLEILDIRGNVDTRLRKLDEGQYHAIILAAAGLKRLKLDDRMT 183 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L + LPAVGQGA+GIE R DD TR+LLA L+H T V AER++ L GC Sbjct: 184 ERLEAPLMLPAVGQGALGIESRSDDPTTRKLLAPLSHAPTLQAVIAERSLLAALRAGCLA 243 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 P+G++A+++DG++ L A+V + DG + AP DA Q+G +AE L GA E+LA Sbjct: 244 PVGAHAQVVDGQLTLAAVVLSIDGQSRLFASLTSAPADAAQLGEEVAELLRQQGATELLA 303 Query: 305 EVY 307 Sbjct: 304 SSR 306 >UniRef50_P28789 Porphobilinogen deaminase n=18 Tax=Saccharomycetales RepID=HEM3_YEAST Length = 327 Score = 370 bits (952), Expect = e-101, Method: Composition-based stats. Identities = 123/322 (38%), Positives = 177/322 (54%), Gaps = 15/322 (4%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M L I R+S LA+ Q+++V + +P ++ + T GD I PL GGK Sbjct: 1 MGPETLHIGGRKSKLAVIQSNHVLKLIEEKYPDYDCKVFTLQTLGDQIQFKPLYSFGGKA 60 Query: 61 LFVKELEVALL----ENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NY 113 L+ KELE L + D+ VHS+KD+P P+G L I +R DP D V Y Sbjct: 61 LWTKELEDHLYHDDPSKKLDLIVHSLKDMPTLLPEGFELGGITKRVDPTDCLVMPFYSAY 120 Query: 114 DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAV 171 SLD LP G IVGTSS+RR QL + P L S+RGN+ TRL KLD+ + Y IILA Sbjct: 121 KSLDDLPDGGIVGTSSVRRSAQLKRKYPHLKFESVRGNIQTRLQKLDDPKSPYQCIILAS 180 Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231 AGL R+GLE+RI + AVGQGA+GIE R D++ ++L + + +E Sbjct: 181 AGLMRMGLENRITQRFHSDTMYHAVGQGALGIEIRKGDTKMMKILDEICDLNATICCLSE 240 Query: 232 RAMNTRLEGGCQVPIGSYAELIDG--EIWLRALVGAPDGSQIIRGE----RRGAPQDAEQ 285 RA+ LEGGC VPIG ++ + ++ L+A+V +G++ + E +D+ Sbjct: 241 RALMRTLEGGCSVPIGVESKYNEETKKLLLKAIVVDVEGTEAVEDEIEMLIENVKEDSMA 300 Query: 286 MGISLAEELLNNGAREILAEVY 307 G LAE ++ +GA++IL E+ Sbjct: 301 CGKILAERMIADGAKKILDEIN 322 >UniRef50_A5VM67 Porphobilinogen deaminase n=9 Tax=Lactobacillus RepID=HEM3_LACRD Length = 305 Score = 370 bits (952), Expect = e-101, Method: Composition-based stats. Identities = 118/298 (39%), Positives = 166/298 (55%), Gaps = 4/298 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + N + + +R+S LA+ Q V L P + E+ ++T GD LAK+GGKG+ Sbjct: 1 MTNKVIVGSRKSKLAMAQTELVIASLEKIFPDIKFEIKNVITEGDRNRHVSLAKIGGKGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALP 120 FVKE+E L + D AVHS+KDV P+ L L +R P D VS SL+ LP Sbjct: 61 FVKEIEDELKDGTIDFAVHSLKDVMPILPEELVLGAFPKRVSPYDCLVSRKNLSSLNDLP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GT+SLRRQ QL RPDL I +RGN+ TRL K+D D IILA AGL RL ++ Sbjct: 121 KGARIGTNSLRRQGQLLSIRPDLKIIPIRGNIDTRLRKIDTEALDGIILAEAGLTRLNID 180 Query: 181 SRIRAALPP-EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 L +PAVGQG + IECR +D+R R++L +N E+A V ER L Sbjct: 181 LSSYHVLDLQNYIMPAVGQGCLAIECRKNDTRIRKMLDQINDEESAYCVQVEREFMRELG 240 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 G C PIG +A +G+I L+ +P+G +I+ + P + +G +A++LL Sbjct: 241 GSCNFPIGGHAYAKNGQILFDGLIASPNGEHVIKETKI--PANNSGVGKKVADQLLAK 296 >UniRef50_UPI00017922DC PREDICTED: similar to porphobilinogen deaminase n=1 Tax=Acyrthosiphon pisum RepID=UPI00017922DC Length = 377 Score = 370 bits (952), Expect = e-101, Method: Composition-based stats. Identities = 130/364 (35%), Positives = 186/364 (51%), Gaps = 59/364 (16%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +R+ +R+S LAL Q +V +L HP + E+V M T GD +LD PL K+G K LF Sbjct: 7 KTIRVGSRKSELALIQTKFVISQLKELHPEIEFEIVSMTTMGDRVLDKPLPKIGEKSLFT 66 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS---LDALP 120 K+LEVALL D VHS+KD+P G + I +R+DPRDA V + LD+LP Sbjct: 67 KDLEVALLSGTVDFIVHSLKDLPTVMEIGTTIGAILKRDDPRDALVLRDDCKEYQLDSLP 126 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE---------YDAIILAV 171 + S +GTSSLRR QL + P+L + +RGN+ TRL KLD+ + Y IILA+ Sbjct: 127 SKSFIGTSSLRRTAQLKRKFPNLQVSDVRGNLNTRLKKLDSSQSTGDNTNTNYSGIILAL 186 Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231 AG++R+G E R+ + ++ L AVGQGA+ +ECRL D E+L L+H+ET L+V AE Sbjct: 187 AGIQRMGWEKRVSQIIDSDVMLYAVGQGALAVECRLGDDYILEMLEPLHHYETVLQVVAE 246 Query: 232 RAMNTRLEGGCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQD------- 282 R TRL GGC P+G + + + L V + DG++ ++ D Sbjct: 247 RGFLTRLGGGCSAPVGIRSTVCLTKNAMSLDGAVWSLDGAEELQYSSSAELADKKVIQSH 306 Query: 283 --------------------------------------AEQMGISLAEELLNNGAREILA 304 A ++G LAE L++ GA +I+ Sbjct: 307 IDQYRGEDGEPPKKCPYKQPRQFVGVTPGKISYLDLDTALKLGTELAENLISKGALDIMN 366 Query: 305 EVYN 308 Sbjct: 367 AAKE 370 >UniRef50_UPI0000583C22 PREDICTED: hypothetical protein n=1 Tax=Strongylocentrotus purpuratus RepID=UPI0000583C22 Length = 324 Score = 370 bits (950), Expect = e-101, Method: Composition-based stats. Identities = 126/319 (39%), Positives = 180/319 (56%), Gaps = 13/319 (4%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 ++R+ +R+S LA+ Q ++V + L HP ++V M T GD I D PLA +G LF Sbjct: 6 EIVRVGSRKSELAMIQTNHVVEMLQKVHPETEFKIVTMETIGDHIQDKPLASIGESNLFT 65 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALP 120 KELE AL + D+ VHS+KD+P P + + ICEREDP DA V + S++ + Sbjct: 66 KELEKALALDEVDMLVHSLKDMPSRLPSNMAIGAICEREDPHDALVLHKKLTGISIETMK 125 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-YDAIILAVAGLKRLGL 179 GS++GTSS+RR QL + P L+ + +RGN+ TRL KLD G+ YD ++LAVAG+ R+G Sbjct: 126 EGSVLGTSSVRRVAQLKRKFPHLVFKDVRGNLNTRLRKLDEGQVYDGLVLAVAGMMRMGW 185 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 E RI L P+I +V QGA+GIE + + R ELL LNH T +R AER + LE Sbjct: 186 EHRISQILKPDICKYSVSQGALGIEIKTKNRRMHELLRQLNHVPTLIRCIAERGLLKTLE 245 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGA------PQDAEQMGISLAEE 293 GGC P+ ++EL + L A + + Q+AE +G+S+A+ Sbjct: 246 GGCSAPVAVHSELEENRHSLDAE---TNEEMKLFSSVIAPWVSQHAMQEAEALGVSVAKG 302 Query: 294 LLNNGAREILAEVYNGDAP 312 L + GA IL A Sbjct: 303 LFDKGAGPILEAAKEEIAE 321 >UniRef50_A9A1A1 Probable porphobilinogen deaminase n=3 Tax=Thaumarchaeota RepID=HEM3_NITMS Length = 311 Score = 369 bits (949), Expect = e-101, Method: Composition-based stats. Identities = 107/298 (35%), Positives = 171/298 (57%), Gaps = 2/298 (0%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 + R S L++ Q + V +L +HP E+ + T+GD PL + KG+F K Sbjct: 2 KYIVGARGSQLSVAQTNLVIAELKKAHPDTEYEIKTITTKGDTD-SRPLFTIDQKGIFEK 60 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E++ A+ + D AVHS+KDVP E L L I +RE D F+S + +LD++ GS+ Sbjct: 61 EIDRAVAQKEVDFAVHSLKDVPSELDDNLVLACIPKRETVNDVFISPDGSTLDSIKPGSV 120 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSSLRR Q++ +RPD+ ++ +RGN+ TR+ K YDAI+LA AG+ RLG++ + Sbjct: 121 IGTSSLRRAVQVSRKRPDVTVKPIRGNIETRIKKASGENYDAIVLAKAGISRLGVDVKYT 180 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L + P+ GQGA+ I R DDS+T E+L + ++ L + AERA++ ++ GC+ Sbjct: 181 E-LSTDDFSPSPGQGAIAIVARADDSKTIEMLKKIEDPDSRLEIEAERALSDFVDSGCRF 239 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 P+G+YA+ E+ L + DG Q + + G + + +G S EEL G ++ Sbjct: 240 PVGAYAKSNGSEMTLTVTAFSVDGKQFLHVSKTGDKNNPKSLGQSAGEELREKGVNDL 297 >UniRef50_C8WXM9 Porphobilinogen deaminase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WXM9_ALIAD Length = 305 Score = 369 bits (949), Expect = e-101, Method: Composition-based stats. Identities = 151/301 (50%), Positives = 196/301 (65%), Gaps = 2/301 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 LR+ATR+S LAL Q ++V D L G+ ELVP+ TRGD I+D L++VGGKGLFV Sbjct: 2 RTLRVATRRSALALTQTNHVVDLLKQVAHGVEFELVPIRTRGDEIVDRALSEVGGKGLFV 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 ++E AL +AD+AVHS+KDVP E GL + + REDPRDA +S L LP G+ Sbjct: 62 ADIEDALATGQADLAVHSLKDVPFELRDGLTIGAVPPREDPRDALISRTGQGLFDLPPGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGTSSLRRQ L RPDL + +LRGNV TRL +L+ G++DAI+LA +GL RLGL RI Sbjct: 122 RVGTSSLRRQAALRRLRPDLCVETLRGNVDTRLRRLEEGQFDAIVLAASGLHRLGLAERI 181 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 LP + +PAVGQGA+ IECR +D LAA+ + V AERA +RLEG CQ Sbjct: 182 TEYLPVDRFVPAVGQGALAIECRAEDDEVMRHLAAIADPDATRAVEAERAFLSRLEGSCQ 241 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 VPIG+YAE + E+ L A V P G ++ ER G +A +G+++AEE+L GA + L Sbjct: 242 VPIGAYAEPVGHELRLIAFVADPSGIHHLQLERTG--DEARALGVAMAEEMLRQGAEDWL 299 Query: 304 A 304 Sbjct: 300 K 300 >UniRef50_UPI0001926E0E PREDICTED: similar to hydroxymethylbilane synthase, partial n=1 Tax=Hydra magnipapillata RepID=UPI0001926E0E Length = 418 Score = 368 bits (946), Expect = e-100, Method: Composition-based stats. Identities = 122/342 (35%), Positives = 166/342 (48%), Gaps = 35/342 (10%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + + +R+S LA+ Q + L + + M T GD IL L K+G K LF Sbjct: 28 KTSVVVGSRKSQLAVIQTKSIVAALCQKEKDVECIIETMDTLGDKILHIALPKIGEKSLF 87 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDAL 119 K+LE+AL E R D VHS+KD+P PQG+ + TI +R+DPRD + + L L Sbjct: 88 TKDLELALSEKRVDFLVHSLKDLPTTLPQGMAISTIYKRDDPRDCIIFHPKHNGKKLADL 147 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-YDAIILAVAGLKRLG 178 P SI+GTSSLRR QL + L +S+RGN+ TRL KL+ YDAI+LA AG+ R+G Sbjct: 148 PENSIIGTSSLRRVAQLKRKYNKLTFQSVRGNLNTRLQKLEEESLYDAIVLAKAGVDRMG 207 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 +I L + L A+GQGA+ +E R DD T +LA L ET L AER L Sbjct: 208 WTEKIGQILSEDECLYAIGQGAITVEVRNDDKYTISILAQLTDMETLLACVAERCFMRTL 267 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ----------------- 281 GGC PI +++ LR +V DGS+ + Q Sbjct: 268 NGGCSTPIACHSQFSGNNYSLRGIVLNADGSRFLDSTVSTTLQVNILTDQNEPPSYTVSK 327 Query: 282 --------------DAEQMGISLAEELLNNGAREILAEVYNG 309 AE+ G LA L GA ++L EV + Sbjct: 328 SGVVINSLYINEFIKAEKCGEELAYCLKKLGADDVLKEVRSK 369 >UniRef50_B0K2L4 Porphobilinogen deaminase n=7 Tax=Bacteria RepID=B0K2L4_THEPX Length = 299 Score = 368 bits (946), Expect = e-100, Method: Composition-based stats. Identities = 110/296 (37%), Positives = 172/296 (58%), Gaps = 3/296 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + V+++ TR S LAL Q V +++ E+V + T+GD ++D P++++GGKG+ Sbjct: 1 MKKVIKVGTRSSELALKQTAMVINEIKKFRQDFEFEIVKITTQGDALIDKPVSEIGGKGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKE+E ALL+ D+AVHSMKD+P E P+GL L+ + +REDP+D FVS + L Sbjct: 61 FVKEIESALLKGEIDMAVHSMKDMPYEIPKGLKLMAVLKREDPKDVFVSGDGTQFMDLKE 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ +GTSSLRRQ QL +PD+ I +RGNV TRL K++ D I+L+ AGL RLGLE+ Sbjct: 121 GAKIGTSSLRRQVQLKALKPDIQIVPIRGNVRTRLKKMEELNLDGIVLSAAGLHRLGLEN 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLEG 240 I PP++ +PA QG + +E D+ +E + +T + ER + Sbjct: 181 IITEYFPPDVVVPAPCQGILAVEIAESFDNIFQEFYPYIVDRKTFFEASVERELLKAFGV 240 Query: 241 GCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 C+ P G+YA+ + E + V +++++ E G ++ ++M L EE Sbjct: 241 NCRQPFGAYAQYRKEEDEEKINIKVAYQKENKLLKSEVTGLIEETDKMIEKLIEEF 296 >UniRef50_C1CYD9 Porphobilinogen deaminase n=3 Tax=Deinococci RepID=HEM3_DEIDV Length = 311 Score = 367 bits (944), Expect = e-100, Method: Composition-based stats. Identities = 126/310 (40%), Positives = 176/310 (56%), Gaps = 5/310 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDT--PLAKVGGKGL 61 + + TR S LAL Q +V +L P + + T+GD ++ +A+ G KG Sbjct: 2 RTVTVGTRGSTLALAQTRWVVARLKEEWPDTDFRIQTISTKGDRNRESLEAMAQKGDKGF 61 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALP 120 +VKE+E ALL+ R DIAVHS+KD+P E P+GL + +I +R D RD + L LP Sbjct: 62 WVKEIEDALLQKRIDIAVHSLKDLPTEQPEGLEVASIPKRVDARDVLIGKEGMKRLADLP 121 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGTSS+RR+ L RPDL + LRGN+ TRL+ L EYDAIILA AGL R + Sbjct: 122 QGARVGTSSVRRKAFLRAYRPDLQVIDLRGNIDTRLAALAGDEYDAIILAAAGLIRTEMR 181 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSR--TRELLAALNHHETALRVTAERAMNTRL 238 RI + P+I LPA GQGA+ +E R T E+ A++ H T R+TAER L Sbjct: 182 HRIDEFVEPDILLPAPGQGALALETRSGPENDLTIEVAYAIHDHGTDDRITAEREFLAGL 241 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GC P+G++A + G + L VGA DGS++IR G P + +G LA ++L G Sbjct: 242 GAGCMAPVGAHASIKGGVLTLEGWVGALDGSKVIRATSIGDPAECADIGAELAGDMLGQG 301 Query: 299 AREILAEVYN 308 A+ ++ Sbjct: 302 AQALIDAARE 311 >UniRef50_Q3YSA8 Porphobilinogen deaminase n=17 Tax=Rickettsiales RepID=HEM3_EHRCJ Length = 298 Score = 367 bits (942), Expect = e-100, Method: Composition-based stats. Identities = 111/293 (37%), Positives = 174/293 (59%), Gaps = 3/293 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LAL Q V + L P + +++V + T GD+ P+ +GGKGLF+KE Sbjct: 3 IRIGTRGSVLALAQTLEVTNLLNRYFPEINIQVVKIKTSGDINNKVPINTIGGKGLFIKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E ALL + D+AVHS+KD+P + GL + + +R P D FVS+ Y S+ +LP + V Sbjct: 63 IEEALLIGKVDLAVHSVKDIPAFYCDGLIIPCVLKRSSPYDVFVSSKYQSIKSLPINATV 122 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR+ QL RPDL + +RGN+ TR+ K D GE+D I+LA AGL R+ + I+ Sbjct: 123 GTSSIRRKVQLNYLRPDLQVIPVRGNIDTRILKSDIGEFDGIVLAEAGLIRINKCNVIKE 182 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L +I L AVGQGA+ ++CR DD + LN H++ + V AER+ + G C P Sbjct: 183 VLDSKIMLSAVGQGAICVQCRADDYNIINKIKVLNCHKSYVCVIAERSFLKTINGSCDTP 242 Query: 246 IGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 + + A+ + I++ ++ +++ + +AE+ GI + ++L+N Sbjct: 243 LAALAQYVDSDTIYMSCMLSNE--KEMVFSDCYFKECNAEESGIDMGKKLINE 293 >UniRef50_C3WGN0 Porphobilinogen deaminase n=5 Tax=Fusobacterium RepID=C3WGN0_9FUSO Length = 301 Score = 366 bits (941), Expect = e-100, Method: Composition-based stats. Identities = 122/311 (39%), Positives = 172/311 (55%), Gaps = 13/311 (4%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPL--AKVGGK 59 + + I +R S LAL QA VK+ L A++P L E+ +VT GD L + + K Sbjct: 1 MKRHVVIGSRGSILALAQASLVKNSLEANYPDLTFEIKEIVTSGDKDLKSNWENSNASLK 60 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 F KE+E LL+ + DIAVHSMKD+P P+GL I +RED RD +S N L L Sbjct: 61 SFFTKEIEQELLDGQIDIAVHSMKDMPAVSPKGLICGAIPDREDARDVLISKNGF-LVTL 119 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P G+ +GTSSLRR L RPD I+ LRGN+ TRL KL+ +YDAIILA AGLKR G+ Sbjct: 120 PQGAKIGTSSLRRVMNLKAIRPDFEIKHLRGNIHTRLKKLETEDYDAIILAAAGLKRTGM 179 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 +I L E PA QG + I+CR +D + +L ++++ + A V ER + + Sbjct: 180 ADKITEYLSGEAFPPAPAQGVLYIQCRENDEEIKGILKSIHNEDIAKIVEIEREFSKIFD 239 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GGC P+G Y+++ + +I A + DG Q R +D G +A + A Sbjct: 240 GGCHTPMGCYSQVDEDKIKFIAAY-SHDGKQ-----IRVVIEDDLTKGKEIA----HMAA 289 Query: 300 REILAEVYNGD 310 EI A++ G+ Sbjct: 290 EEIKAKINKGN 300 >UniRef50_D1CBT4 Porphobilinogen deaminase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CBT4_THET1 Length = 300 Score = 364 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 111/295 (37%), Positives = 170/295 (57%), Gaps = 2/295 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 V+++ TR S LALWQ +V ++L + +PG E V + D D P++ +G G+F Sbjct: 2 KVIKVGTRGSKLALWQTQWVINRLRSLYPGFQFEPVVIKVTSDRSPDAPISAIGQVGVFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 K++E ALL +AVHS+KD+P G + EREDPRD + + L S Sbjct: 62 KDIEQALLAGDIHLAVHSLKDLPTLSTPGTVIAAFTEREDPRDCILWPKGQPMPDL-NNS 120 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGTSS+RR + P+ + +LRGNV TR+ K+ G YD +++A A +KR+ L Sbjct: 121 RVGTSSVRRSALVRSYWPNANVVNLRGNVDTRVRKMLEGNYDVVLMAYAAVKRMDLPVEF 180 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + LP + +P+ GQG + ++ R DD + +L A+N + + AER++ L GGC Sbjct: 181 K-PLPLDSWVPSAGQGIIAVQAREDDQQIIGMLNAINFFPSKVAYLAERSLMRALGGGCS 239 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 +P+G+YAEL DGE+ L +V APDGSQ++ R P A+ +G +A E+L+ G Sbjct: 240 MPVGAYAELHDGELSLIGMVAAPDGSQVVITRRVDTPDQADHLGERVAREMLDLG 294 >UniRef50_C3XEZ5 Porphobilinogen deaminase n=3 Tax=Campylobacterales RepID=C3XEZ5_9HELI Length = 328 Score = 364 bits (935), Expect = 2e-99, Method: Composition-based stats. Identities = 146/315 (46%), Positives = 188/315 (59%), Gaps = 12/315 (3%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + L + TR S LALWQA+++K+KL + G V L + T+GD ILD PLAK+GGKGLF Sbjct: 12 EKPLVLGTRGSLLALWQANHIKEKLESL--GFQVVLKTIKTKGDKILDAPLAKIGGKGLF 69 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 KELE LL D AVHS+KDVP+ P L LV+I +RED RD FVS Y + +LP G Sbjct: 70 TKELENELLSGGIDFAVHSLKDVPIAIPPELMLVSITQREDARDCFVSEKYADIASLPQG 129 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 + VGT+SLRR QL R DL +SLRGNV TRL KL GE+DAIILA AGL RL L+ Sbjct: 130 AKVGTTSLRRSMQLKRIRQDLDTQSLRGNVQTRLEKLRKGEFDAIILASAGLNRLDLKDD 189 Query: 183 IRAA--LPPEISLPAVGQGAVGIECRL-------DDSRTRELLAALNHHETALRVTAERA 233 I L +PA+GQG++GIECR D ++L +L+ ++AL ERA Sbjct: 190 IGFISHLQINQFIPAMGQGSLGIECRDPKYSPDFRDQAIMKVLESLHDSKSALCCNIERA 249 Query: 234 MNTRLEGGCQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAE 292 L GGCQ PIG +A++ EI ++ +VG D S+++ R + E + Sbjct: 250 FIQLLGGGCQSPIGIHAQILDSKEIEIQCVVGNLDASKVLTETRVCNKGEVEYALQDMIN 309 Query: 293 ELLNNGAREILAEVY 307 L NG EIL EV Sbjct: 310 TLKKNGVMEILEEVR 324 >UniRef50_Q5HBG1 Porphobilinogen deaminase n=2 Tax=Ehrlichia ruminantium RepID=Q5HBG1_EHRRW Length = 299 Score = 362 bits (930), Expect = 9e-99, Method: Composition-based stats. Identities = 112/298 (37%), Positives = 175/298 (58%), Gaps = 3/298 (1%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M + + TR S LA+ QA VK L P + V++V +VT GD+ L+++GGKG Sbjct: 1 MNSMNVYVGTRGSILAIAQAMEVKKLLYNYFPDINVQIVHIVTSGDINDKISLSEIGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF+KELE ALL D+AVHSMKDVP + L + I +R P D F+S+ Y SL +LP Sbjct: 61 LFLKELEEALLTGTIDLAVHSMKDVPAFYCDSLVIPCILKRSSPYDVFISSKYQSLRSLP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 +++GTSS+RR+ QL + + +RGNV TR+ KL+ G+YD IILA AGL R+ Sbjct: 121 DNAVIGTSSIRRKVQLMRLLSSVQVVPIRGNVDTRILKLEAGQYDGIILAKAGLMRINKT 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 I+ L P++ L AVGQGA+GI+CR +D + +++ LN ++ + V AER+ + G Sbjct: 181 HVIKEVLDPQVMLSAVGQGAIGIQCRANDYKMIDMIKILNCKKSYISVAAERSFMKTVNG 240 Query: 241 GCQVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 C P+ + A+ + +++ ++ + + + DAE GI++ +L++ Sbjct: 241 SCDTPLAALAKYVNSDTLYMSCMLSNE--EKTVFSDCYFNECDAEISGINMGNDLMDQ 296 >UniRef50_C6XGK7 Porphobilinogen deaminase n=1 Tax=Candidatus Liberibacter asiaticus str. psy62 RepID=C6XGK7_LIBAP Length = 307 Score = 360 bits (925), Expect = 4e-98, Method: Composition-based stats. Identities = 113/297 (38%), Positives = 162/297 (54%), Gaps = 2/297 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGG 58 M RI TR SPLAL A + LM H P + ++P+ T+GD I + L ++GG Sbjct: 1 MEKKPFRIGTRCSPLALAHAFETRSSLMDVHKIPPHNIVIIPLSTKGDRITNRTLTEIGG 60 Query: 59 KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118 KGLF +E+E L+ D AVHS KD+P + +GL + RED RD F+S+ SL Sbjct: 61 KGLFTEEIEKKLISGEIDCAVHSAKDMPTKLLKGLQISAYLPREDIRDVFISHTAQSLKD 120 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 L S++GTSSLRR+ L R D+ + RG + TRL+KL+N + AI+LA AG+KRL Sbjct: 121 LALHSVIGTSSLRRKALLLRWRSDISVIDFRGKIETRLNKLNNNKAHAILLAYAGIKRLK 180 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 E I+ L E P+ GQGA+ IE +++ + +EL+ +NH +T V ERA L Sbjct: 181 KEKVIKEILNIEDFPPSPGQGAICIETHVNNPKAQELVKVINHEDTWDSVNCERAFLAEL 240 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295 +G C+ I +A ++ +V A DG R G DA +G A+ + Sbjct: 241 DGSCKSAIAGFAYCKGSTLYFYGIVLASDGKIFHEVSRNGNRCDAINIGRDAAQYIR 297 >UniRef50_Q2S2A6 Porphobilinogen deaminase n=1 Tax=Salinibacter ruber DSM 13855 RepID=Q2S2A6_SALRD Length = 323 Score = 359 bits (923), Expect = 6e-98, Method: Composition-based stats. Identities = 144/307 (46%), Positives = 192/307 (62%), Gaps = 5/307 (1%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + L + TR S LAL QA+ V+ +L A+ G VEL + TRGD DTP++++G + +F Sbjct: 4 SDPLVLGTRGSELALRQANVVRSRLEAA--GHRVELETITTRGDEATDTPISEIGDEAVF 61 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN--YDSLDALP 120 KEL+ ALL+ D+AVHS+KD+P P GL L I EREDPRDAFV++ L LP Sbjct: 62 TKELDRALLQGGVDLAVHSLKDIPSTVPSGLALAAIGEREDPRDAFVAHPSFDGHLHDLP 121 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ V T+SLRR QL R DL + +RGNV TRL KL ++ ++LAVAGL RLGL Sbjct: 122 EGATVATASLRRTAQLLTWRSDLEVVPVRGNVDTRLEKLGESDWTGMVLAVAGLVRLGLS 181 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLA-ALNHHETALRVTAERAMNTRLE 239 IR + P + +PAVGQGA+GI CR D R+LL L+H + AERA ++ Sbjct: 182 LHIRDRIDPSLIVPAVGQGALGIACREDQDALRDLLRETLHHAPSGHAANAERAFLKKVG 241 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GGCQVP+G++A + DG + L A + A DGS+ R ERR AP+D +G LA +LL G Sbjct: 242 GGCQVPLGAWAHIDDGTLVLDACIAALDGSEHYRDERRCAPEDGAAVGRKLAADLLAMGG 301 Query: 300 REILAEV 306 IL +V Sbjct: 302 DHILDDV 308 >UniRef50_D0NJW2 Porphobilinogen deaminase n=2 Tax=Phytophthora infestans T30-4 RepID=D0NJW2_PHYIN Length = 361 Score = 358 bits (920), Expect = 1e-97, Method: Composition-based stats. Identities = 124/320 (38%), Positives = 174/320 (54%), Gaps = 11/320 (3%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGK--- 59 + +++R+S LA+ Q + V L P L + T GD +LD L+ +G Sbjct: 13 KRTIFVSSRKSQLAMAQTNTVIAMLEERFPDLQFVVGQEDTVGDQVLDRHLSDLGTTTAS 72 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY------ 113 GLF K LE ALL A AVHS+KD+P P GL L I +RE P DA V + Sbjct: 73 GLFTKSLEEALLAKAASFAVHSLKDMPTTLPDGLVLAAITKRESPEDAAVIHPKHKEKGI 132 Query: 114 DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-YDAIILAVA 172 +L LP GS++GTSSLRR+ L + P I+++RGN+ TRL+KLD + YDAII+A Sbjct: 133 KTLQELPEGSVIGTSSLRREALLRSQFPTFEIKTVRGNIQTRLAKLDEHDDYDAIIVAAC 192 Query: 173 GLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232 G +R L RI LP + VGQG++G+ECR DD T E+L + ++A AER Sbjct: 193 GFRRGELGDRIDEILPMDTFGYGVGQGSIGVECRADDEETIEMLKTITDEKSAQLCKAER 252 Query: 233 AMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAE 292 ++ LEGGCQ+ +G A L + + L A V + DG + + G E++G LAE Sbjct: 253 SLLYHLEGGCQIAMGVSATLDEDTLTLNATVLSRDGKESVHETISGPRTQCEELGKQLAE 312 Query: 293 ELLNNG-AREILAEVYNGDA 311 NN AR++L + A Sbjct: 313 RFWNNELARKVLGKTRQKRA 332 >UniRef50_Q4HT06 Porphobilinogen deaminase n=1 Tax=Campylobacter upsaliensis RM3195 RepID=Q4HT06_CAMUP Length = 308 Score = 356 bits (914), Expect = 7e-97, Method: Composition-based stats. Identities = 151/307 (49%), Positives = 201/307 (65%), Gaps = 4/307 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L IATR+SPLALWQ+ +V D L +H G+ V L T+GD++LD+PLAK+GGKGLF Sbjct: 2 KKLIIATRKSPLALWQSEFVADILRKTH-GIEVHLEGFSTKGDILLDSPLAKIGGKGLFT 60 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE A+LEN+A +AVHS+KDVP PQGL L + RED DA +S Y L+ALP + Sbjct: 61 KELENAMLENKAHLAVHSLKDVPSFLPQGLVLAALSVREDDTDALLSELYKDLNALPQNA 120 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGT+SLRR+ QL RPDL I +LRGNV +RL +L GE+DAIILA AG+KRLGLES + Sbjct: 121 KVGTTSLRRKMQLLSLRPDLHIINLRGNVNSRLKRLKGGEFDAIILASAGVKRLGLESEV 180 Query: 184 RAA--LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + + +PA QG +GI+ D + LL LN ++ + T ER LEGG Sbjct: 181 KFIYRFSKDELVPAATQGILGIQS-PDKNEILTLLQCLNDEKSLIESTVERDFIRTLEGG 239 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 CQVPIG AEL+ +I +R+++G PDGS+I+R +R ++ + G LA E + GA+E Sbjct: 240 CQVPIGINAELMGEQITVRSILGLPDGSEILRDKRIILKKNYQGFGERLALEFIKRGAKE 299 Query: 302 ILAEVYN 308 +L Sbjct: 300 LLKRAEA 306 >UniRef50_C7N5L0 Porphobilinogen deaminase n=2 Tax=Slackia RepID=C7N5L0_SLAHD Length = 318 Score = 355 bits (913), Expect = 8e-97, Method: Composition-based stats. Identities = 121/313 (38%), Positives = 167/313 (53%), Gaps = 5/313 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + I TR S LALWQ V +M + P + VE+ T GD+ L +PLA++G KGL Sbjct: 1 MPERFVIGTRGSKLALWQTETVGRAIMRAFPEIEVEIRVRNTTGDINLASPLAEIGDKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDA 118 F +ELE LL D+ VHS+KD+ E P+G + + R D RD V SL Sbjct: 61 FTRELETDLLLGEVDMCVHSLKDLETEQPEGCVVAGVLPRADARDVLVCGPRIQAASLAE 120 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 +P GS +GT S RR QL P+++ +RGNV TR++K + +Y+ ILA AG+KR+G Sbjct: 121 VPEGSRIGTGSRRRVAQLKANFPNMVPEGIRGNVDTRVAKAEGDDYEGAILAAAGMKRMG 180 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 E I A LP E +PA GQGA+ +E + R ++ ALN T AER + L Sbjct: 181 YEDHIAAYLPIEDMIPAPGQGAIAMEVLKKNERAYQIARALNDPVTKACTDAERFVLFSL 240 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ--DAEQMGISLAEELLN 296 EGGC PIG++ L DG+ A V + G++ R D M + EL+ Sbjct: 241 EGGCSAPIGAHCRLEDGKYIFDACVLSLGGTKAARCHLEADADSADPMDMAWEVVSELIG 300 Query: 297 NGAREILAEVYNG 309 GAR IL ++ NG Sbjct: 301 EGARAILRDIKNG 313 >UniRef50_B3U3W9 Hydroxymethylbilane synthetase n=1 Tax=Oxyrrhis marina RepID=B3U3W9_OXYMA Length = 395 Score = 355 bits (912), Expect = 1e-96, Method: Composition-based stats. Identities = 128/303 (42%), Positives = 168/303 (55%), Gaps = 3/303 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMA-SHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR SPLAL QA V+ + G +++ + T GD ILD LA VGGKGLF K Sbjct: 76 LRIGTRGSPLALAQARDVESRAREQLQQGGEIDICVISTEGDRILDRALADVGGKGLFTK 135 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 EL+ ALL D VHSMKDVP G +V RED RD F+S Y +L LP G++ Sbjct: 136 ELDRALLSGEVDCCVHSMKDVPTTVAPGTEIVAYLPREDTRDVFLSAKYATLADLPDGAV 195 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGT+SLRRQ Q+ ++ ++++ + RGNV TRL KL G D LA AGLKRLG+ + Sbjct: 196 VGTASLRRQAQILAQK-NVVVTNFRGNVQTRLRKLAAGTVDCTFLAYAGLKRLGMLAEAT 254 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L LPA+ QGAVGI+ R +D+ R L+ L+H T L V ERA L+G C+ Sbjct: 255 QVLEWSDMLPAIAQGAVGIQIRSNDAALRGTLSQLDHEPTRLAVETERAFLRALDGSCRT 314 Query: 245 PIGSYAELIDG-EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 PI A + + R V + DG Q P D ++G +L ++L E Sbjct: 315 PIAGQAWIGPDSRLAFRGQVLSADGKQRFERVGDCLPCDGPELGKTLGDDLRREAGEEFF 374 Query: 304 AEV 306 AE+ Sbjct: 375 AEL 377 >UniRef50_A8U3E9 Porphobilinogen deaminase n=1 Tax=alpha proteobacterium BAL199 RepID=A8U3E9_9PROT Length = 321 Score = 355 bits (911), Expect = 1e-96, Method: Composition-based stats. Identities = 131/306 (42%), Positives = 178/306 (58%), Gaps = 7/306 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLV--VELVPMVTRGDVILDTPLAKVGGKGLFV 63 L + +R SPLAL Q H V+D+L A+ P L + + + T GD + D PLA++GGKGLF+ Sbjct: 15 LTLGSRGSPLALRQTHEVRDRLAAAWPELAGAIAVQEIRTTGDAVRDRPLAEIGGKGLFI 74 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE+E AL+ + D AVHSMKD+ LV + REDPRDA++S D +D LP+G+ Sbjct: 75 KEIEQALMAGQIDAAVHSMKDMETTIAPASVLVAVLPREDPRDAWLSPIADRVDDLPSGA 134 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +GT+S+RR Q+ RRPDL + RGNV TRL KL GE LA AGL RLG+ + Sbjct: 135 KIGTASVRRAAQVLNRRPDLQVVLFRGNVDTRLRKLAEGEVAGTFLAAAGLSRLGMLDKA 194 Query: 184 RAALPPEISLPAVGQGAVGIECRLD-----DSRTRELLAALNHHETALRVTAERAMNTRL 238 L + LPAV QGA+G++CR D+ R L+ L+ + LRVTAERAM L Sbjct: 195 TRILEVDEMLPAVSQGAIGVQCRDGEASARDAEIRNWLSILDDRPSRLRVTAERAMLATL 254 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 +G C+ PI +A L + L +V + DG A D E +G ++ E +L G Sbjct: 255 DGSCRTPIAGHATLGGARLTLSGMVFSLDGQSSHGAVDTSATDDPEALGRTVGEAILARG 314 Query: 299 AREILA 304 R LA Sbjct: 315 GRNFLA 320 >UniRef50_A6DBT5 Porphobilinogen deaminase n=1 Tax=Caminibacter mediatlanticus TB-2 RepID=A6DBT5_9PROT Length = 295 Score = 354 bits (910), Expect = 2e-96, Method: Composition-based stats. Identities = 132/296 (44%), Positives = 177/296 (59%), Gaps = 8/296 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 L IATR S LALWQA +VK +L G V+L + T GD ILD PLA +GGKGLF+K Sbjct: 2 KLTIATRGSKLALWQAEWVKKRLENL--GHEVDLKIVTTTGDKILDKPLASIGGKGLFIK 59 Query: 65 ELEVALLENRADIAVHSMKDVPVEF-PQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 E+E ALL A IAVHS+KD P E+ + L + +RE D F+S +++L LP + Sbjct: 60 EVEEALLRGEAQIAVHSLKDFPTEYNKEHFTLAAVPKREAVEDVFLSETFETLAELPHNA 119 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL--ES 181 +VGTSS+RR QL R DL+I LRGNV TR++KL GEYDAIILA AG+KRL L E Sbjct: 120 VVGTSSIRRAMQLKAFREDLVISDLRGNVDTRINKLKKGEYDAIILAYAGVKRLNLIKEV 179 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + L +I +PA+GQGA+GIE + D + E + LN T + VT ER L G Sbjct: 180 KYFEILDTDIMIPAMGQGALGIET-IKDEKVIEAVKPLNDLWTKIEVTIERDFIDELNLG 238 Query: 242 CQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 C P+G A++ +D I ++A + + +++I+ E + E G AEE Sbjct: 239 CHAPVGVNAKIMVDDSIKIKAAILDKN-NKVIKKEMVVPFDEWENAGREFAEEFKE 293 >UniRef50_A6GVP0 Hydroxymethylbilane synthase n=18 Tax=Bacteroidetes RepID=A6GVP0_FLAPJ Length = 308 Score = 354 bits (909), Expect = 2e-96, Method: Composition-based stats. Identities = 111/311 (35%), Positives = 173/311 (55%), Gaps = 8/311 (2%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M ++I TR S LALWQAH+V+ L G +++ + ++GD+ILD PL ++G G Sbjct: 1 MAKKTIKIGTRDSELALWQAHHVEKMLNDL--GHKTKIIAVKSQGDIILDKPLYELGITG 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 +F K L++A++ DIAVHSMKDVP PQG+ + ER + +D V NN +LD L Sbjct: 59 IFTKTLDIAMVNGDIDIAVHSMKDVPTALPQGIVQAAVLERANEKDILVYNN--NLDFLN 116 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 + + T SLRRQ Q + P+ + LRGNV TR+ KL + ++ + A AGL+R+ ++ Sbjct: 117 TQATIATGSLRRQAQWLHKYPNHKVVDLRGNVNTRMQKLQDNNWNGAVFAAAGLERINIK 176 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 + + +PA QGA+ + +D+ + LA LNH ET + ER LEG Sbjct: 177 PE--NYINLDWMIPAPAQGAMMVVAMGNDTYCLDALAELNHIETEITTYIERQFLRTLEG 234 Query: 241 GCQVPIGSYAE--LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GC PIG+YA D I + ++ + DGSQ I ++ Q+ +Q+G +E+ NG Sbjct: 235 GCTAPIGAYARFNEKDETIHFQGVLFSLDGSQKIEIKKIVEIQEWKQLGYHAGQEIFENG 294 Query: 299 AREILAEVYNG 309 +++ + Sbjct: 295 GVQLMKTIKEK 305 >UniRef50_A6GB01 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=A6GB01_9DELT Length = 322 Score = 353 bits (906), Expect = 6e-96, Method: Composition-based stats. Identities = 138/309 (44%), Positives = 182/309 (58%), Gaps = 6/309 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 LR+ TR S LALWQA+ ++D+L+A+ GL VELV +VT+GD + D PL +VGG GL Sbjct: 9 RKLRLGTRGSALALWQANMIRDRLLAAWGAQGLEVELVRVVTKGDRVTDRPLNQVGGMGL 68 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD--SLDAL 119 FVK LE LL D AVHSMKD+P P+GL L + ER DPRDAF++ +L L Sbjct: 69 FVKGLEDKLLAGEIDFAVHSMKDMPGTLPEGLTLASTPERADPRDAFLAAPGRDVTLATL 128 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 PAGS +GTSSLRR P L I +RGNV TR+ K+ GE DA++LA AGL RLG Sbjct: 129 PAGSRLGTSSLRRGALAKRINPGLEIVPIRGNVPTRMGKIAEGEVDAVLLAAAGLDRLGK 188 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 I L P+ +PA QG + IE R D+ L L H T++ AER+ L+ Sbjct: 189 GEAITERLDPDAFMPAACQGVLAIELRAADTDIAALFEPLGHGPTSIVAAAERSYLATLQ 248 Query: 240 GGCQVPIGSYAELIDG--EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 GGCQVP+ +A L + + + LV PDGS + E G DA Q+G +A E+L Sbjct: 249 GGCQVPLACHARLSEDGRRVRVEGLVVEPDGSTVYASEAEGPVADAAQLGAGVAREVLAA 308 Query: 298 GAREILAEV 306 G + ++ + Sbjct: 309 GGQGVIDRL 317 >UniRef50_C4Z552 Porphobilinogen deaminase n=8 Tax=Bacteria RepID=HEM3_EUBE2 Length = 295 Score = 352 bits (905), Expect = 7e-96, Method: Composition-based stats. Identities = 122/291 (41%), Positives = 166/291 (57%), Gaps = 5/291 (1%) Query: 7 RIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66 RI TR S LAL Q+ YVK ++ ++P ELV + T GD + D PLA +G KG FVKE+ Sbjct: 4 RIGTRGSKLALVQSEYVKRRMEEAYPEDTFELVIIKTTGDKVTDKPLAAIGTKGFFVKEI 63 Query: 67 EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126 E ALL D+AVHSMKD+P E GL +RED RD + S LP+G+++G Sbjct: 64 EEALLSGSIDMAVHSMKDMPAECAAGLTFAKAWKREDCRDVLILKTAGSFSELPSGAVIG 123 Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY--DAIILAVAGLKRLGLESRIR 184 T SLRR CQLA RPD+ ++RGNV TR++KL + Y D I+LA AGL RLG S I Sbjct: 124 TGSLRRACQLAMLRPDIQFTAIRGNVDTRINKLMDDSYGLDGIVLAAAGLNRLGRSSEIT 183 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L PE+ +PA QG + IE ++ + + AL+ + AER GGC Sbjct: 184 EYLDPEVVIPAPAQGVLAIETAEVNTELLDKINALSDDNSDREAVAERTFLRLTGGGCHA 243 Query: 245 PIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 P+G++ +G++ + L G D S+I+R E G D+E +G A L Sbjct: 244 PVGAHCVTKDNGDLRMVVLFGNDDCSRILRIEVTGT--DSEAVGHEAARML 292 >UniRef50_Q11XT5 Porphobilinogen deaminase n=8 Tax=Bacteria RepID=HEM3_CYTH3 Length = 312 Score = 351 bits (901), Expect = 2e-95, Method: Composition-based stats. Identities = 125/310 (40%), Positives = 172/310 (55%), Gaps = 4/310 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 ++ +RI TR S LALWQA +V L GL ++V + T GD ILD L+K+G KGL Sbjct: 1 MNKTVRIGTRGSKLALWQAEHVAACLQTK--GLEPQIVIIDTTGDKILDQSLSKIGSKGL 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F +ELE L DIAVHS KD+ G+ ++ I ERE D VS+ Sbjct: 59 FTEELEEQLHAGTIDIAVHSAKDLQTHLKGGMYILAITERELVNDVLVSHKPIDTLKNNP 118 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 I+GTSS RR+ L + P + +RGN+ TR+ K++ G DA++LA AG+ R+G +S Sbjct: 119 DLIIGTSSTRRRALLRKFYPQAKMVDMRGNLQTRIRKMEEGACDAMLLAYAGMHRMGYDS 178 Query: 182 RIRAALPPEISLPAVGQGAVGIECRL--DDSRTRELLAALNHHETALRVTAERAMNTRLE 239 I+ L E +PA GQG + IE D + + A LN T V+AERA LE Sbjct: 179 LIKEKLSLEEFIPAAGQGTLAIEAASTLDKEKAAVIRAVLNDAATETAVSAERAFLRTLE 238 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GGC +P+ + A D + L + + DG++ +R E R DAEQ G+ LA LL +GA Sbjct: 239 GGCSIPVFALAVERDTDYLLTGGIVSLDGTKYLRKEIRFTAADAEQRGVELATVLLKDGA 298 Query: 300 REILAEVYNG 309 EILAE+ G Sbjct: 299 DEILAEIKKG 308 >UniRef50_UPI00006CBE06 porphobilinogen deaminase family protein n=1 Tax=Tetrahymena thermophila RepID=UPI00006CBE06 Length = 362 Score = 351 bits (901), Expect = 2e-95, Method: Composition-based stats. Identities = 123/340 (36%), Positives = 178/340 (52%), Gaps = 32/340 (9%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKL----MASHPGLVVELVPM--------------- 41 + + +IA+R S LAL Q + V D L E+VP+ Sbjct: 16 LKNRKFKIASRSSQLALSQTYEVIDLLVGVKELGLTKENFEVVPISNAPGKNCTLKFKIN 75 Query: 42 ------VTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGL 95 +GD L PL +GG G+F K +EV LL DIAVHS+KD+P + L + Sbjct: 76 ITNKQFTNKGDQNLKDPLYVMGGVGVFTKIVEVELLNKNGDIAVHSLKDLPTIIDERLFI 135 Query: 96 VTICEREDPRDAFVS---NNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNV 152 + + D + + L LP GS++GTSSLRR L R P L ++RGN+ Sbjct: 136 GAVPPLKPRGDVVIFNEKHKGKELKDLPEGSVIGTSSLRRITNLKNRYPHLKYENIRGNL 195 Query: 153 GTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRT 212 TRL+KL+NG+YDAIILA AG+ RLG ++ L E L A GQGA+G++CR DD Sbjct: 196 NTRLTKLENGQYDAIILAEAGVFRLGWIEKVGQFLKQEDFLYAPGQGALGVQCRADDKEA 255 Query: 213 RELLAALNHHETALRVTAERAMNTRLEG---GCQVPIGSYAELIDGEIWLRALVGAPDGS 269 LL+ +N E +RV AER +LEG GC++PI ++E+ID + L V + + Sbjct: 256 IALLSYINQKEPRIRVDAERQFLNKLEGVILGCKLPIAVHSEIIDQTLRLTGQVWSLEAD 315 Query: 270 QIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYNG 309 + IR G D + +G+ L+E++ GA EIL ++ + Sbjct: 316 KTIREVIEGHISD-QDLGLKLSEKMKQAGAGEILEKIRSQ 354 >UniRef50_A9FDP9 Porphobilinogen deaminase n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=HEM3_SORC5 Length = 300 Score = 351 bits (901), Expect = 2e-95, Method: Composition-based stats. Identities = 152/299 (50%), Positives = 196/299 (65%), Gaps = 4/299 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + L +ATR+S LAL Q+ L A+ P L + + +VT GD D L +GGKGL Sbjct: 1 MPTELTLATRRSALALAQSRAFARSLEAAVPDLSLRELEVVTSGDKTQDRSLQDIGGKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F+KELE ALL+ RAD AVHS+KDVP E L L I REDPRDA V+ + L LPA Sbjct: 61 FIKELEEALLDRRADFAVHSIKDVPAEIAPALCLACIPAREDPRDALVTRSGALLAELPA 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ VGTSSLRR L E RPDL+I +RGNV TRL K+ +G +DA++LA+AGLKRLGLE+ Sbjct: 121 GARVGTSSLRRAVALREARPDLVIEPVRGNVDTRLRKVFDGVFDAVVLALAGLKRLGLEA 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 R L PE+SLPA+GQGA+GIECR D R++L L ET + V+AERA+ +EG Sbjct: 181 RATEVLSPEVSLPAIGQGALGIECRTADDSVRDVLGTLADAETTICVSAERAVMAAVEGS 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR----GAPQDAEQMGISLAEELLN 296 C+ P+ +YA G +WLRAL+ PDGS++ R ERR G ++AE++G L EL Sbjct: 241 CRTPVAAYAVRDGGALWLRALLAEPDGSRLRRAERRLSWPGNTREAERLGADLGAELKK 299 >UniRef50_C1AA38 Porphobilinogen deaminase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1AA38_GEMAT Length = 309 Score = 350 bits (899), Expect = 4e-95, Method: Composition-based stats. Identities = 151/311 (48%), Positives = 186/311 (59%), Gaps = 6/311 (1%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M+ +RI TR S LAL QA V +L A G+ ELV T GD ILD PL+ +G KG Sbjct: 1 MMTVPVRIGTRSSELALRQARQVAAQLDAR--GVPSELVEYTTLGDRILDRPLSAIGEKG 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLD 117 LF ELE LL R D AVHS+KD+P PQG+ +V + EREDPRDA V SLD Sbjct: 59 LFTAELEADLLAGRIDCAVHSLKDLPTADPQGIIVVALLEREDPRDALVVRAGVDAHSLD 118 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177 LP G+ VGTSSLRR+ QL R DL + LRGNVGTRL KLD G+ DA +LA AGL RL Sbjct: 119 TLPEGARVGTSSLRRRAQLQALRSDLEVCELRGNVGTRLRKLDEGQVDAALLAAAGLHRL 178 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 GL RI A L L A GQGA+ ++ R DD L++L+H T + VTAERA+ Sbjct: 179 GLADRIVAYLDAPEWLSAPGQGAIAVQGRADDEALLSTLSSLDHAPTRVAVTAERALLAA 238 Query: 238 LEGGCQVPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 LEGGCQVPIG+ E + L A++ + DGS +RG + GI LA +L Sbjct: 239 LEGGCQVPIGAAVLEEPEYGTILHAVIVSLDGSSAVRGGYPVDHANPAASGIELARQLRA 298 Query: 297 NGAREILAEVY 307 G +IL+E+ Sbjct: 299 AGGAQILSEIR 309 >UniRef50_Q1V167 Hydroxymethylbilane synthase n=3 Tax=Candidatus Pelagibacter RepID=Q1V167_PELUB Length = 307 Score = 350 bits (898), Expect = 4e-95, Method: Composition-based stats. Identities = 111/300 (37%), Positives = 168/300 (56%), Gaps = 3/300 (1%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVE---LVPMVTRGDVILDTPLAKVG 57 M + + I +R S LAL A ++K++ +E + +VT+GD + D L++VG Sbjct: 1 MKNRKIIIGSRGSKLALIYAEKAREKILKHSKDFGIEEVIIKEIVTKGDQVQDKRLSEVG 60 Query: 58 GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD 117 GKGLF K +EV LLE + DIAVH++KD+P E +GL ER DPR+ +S + L Sbjct: 61 GKGLFSKTIEVELLEKKIDIAVHALKDMPSEETRGLLTDCFLERNDPREILISKDNKHLK 120 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177 L + SI+GTSS RR+ Q+ + R DL + +RGNV TR+ KL YDAIIL+ AG+ L Sbjct: 121 DLASNSIIGTSSYRREFQIKKIRDDLNCKLIRGNVDTRIRKLKENLYDAIILSYAGIDSL 180 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 GL I +P GQG + ++CR +D ELL ++H T + AER + Sbjct: 181 GLNQNISQTFSTSEIIPCAGQGVIALQCRDNDESLIELLKQVDHQSTHSSIKAERNVLKV 240 Query: 238 LEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 LEG C+ +G++A + +I L + + DGS+ + + AE++GI + + L Sbjct: 241 LEGDCETAVGAFANIEGNKINLEVELFSLDGSKRFYLKSSESVDKAEELGIEMGKTLKKM 300 >UniRef50_B2W5W6 Porphobilinogen deaminase n=2 Tax=Pleosporineae RepID=B2W5W6_PYRTR Length = 399 Score = 350 bits (898), Expect = 4e-95, Method: Composition-based stats. Identities = 128/348 (36%), Positives = 177/348 (50%), Gaps = 45/348 (12%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG----KG 60 + I TR S LA QA V+ L ++P + P++ +GD TPL ++ K Sbjct: 30 PVNIGTRNSVLAQIQARAVERSLKDAYPERTYNICPVIVQGDRDKITPLQQLSQGENAKS 89 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS----NNYDSL 116 L+ ELE L DI VH +KD+P + P L L I EREDPRDA + +L Sbjct: 90 LWTGELESMLESGDLDIIVHCLKDMPTQLPDHLELGAILEREDPRDALLVSPRLPKETTL 149 Query: 117 DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAGL 174 LP G+ +GTSS+RR L + P L LRGNVGTRL+KLD + Y AIILA AGL Sbjct: 150 ATLPQGATIGTSSVRRAATLRKLYPHLKFADLRGNVGTRLAKLDAEDSPYSAIILAAAGL 209 Query: 175 KRLGLESRIRAALPPEI--SLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232 KR+GL++RI L L AVGQGA+GIE R +D +EL++ + T +AER Sbjct: 210 KRMGLDNRITQYLSSTSGGMLHAVGQGALGIEIRKNDEAMKELMSKIRCERTTRACSAER 269 Query: 233 AMNTRLEGGCQVPIGSYAELIDGE------------------------------IWLRAL 262 A+ LEGGC VPIG G+ + +RA+ Sbjct: 270 ALLRTLEGGCSVPIGVETSWKGGKGLSVGPQPAKDYDKHGNAVEEDEPDVDDQELVMRAM 329 Query: 263 VGAPDGSQIIRGERR---GAPQDAEQMGISLAEELLNNGAREILAEVY 307 V + DG + + E ++AE+MG +A+ L+ GA +IL ++ Sbjct: 330 VVSVDGKESVEYEATRKVRNAEEAEEMGREVAKILIEKGADKILEKIN 377 >UniRef50_A3CL78 Porphobilinogen deaminase n=1 Tax=Streptococcus sanguinis SK36 RepID=HEM3_STRSV Length = 306 Score = 349 bits (897), Expect = 6e-95, Method: Composition-based stats. Identities = 126/300 (42%), Positives = 179/300 (59%), Gaps = 7/300 (2%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 V+++ TR+S LA+ Q + D+L A HP LVP T+GD + L ++GGKG+FV Sbjct: 2 KVIKVGTRKSKLAMTQTQQLVDQLKALHPERDFVLVPYTTKGDRLTHVSLQEIGGKGVFV 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALPAG 122 KE+E ALL ++AVHS+KD+P + +G L I +RED RD + +L LP G Sbjct: 62 KEIERALLAGEINMAVHSLKDMPAKLAEGCALGAISQREDVRDCLIFRQAGQTLADLPKG 121 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 S++GTSS+RRQ QL +RPDL + LRGN+ TR+ KL+ GEYDAI+LA+AGLKRLG + Sbjct: 122 SLIGTSSIRRQVQLQAQRPDLAFKPLRGNIDTRIKKLEEGEYDAIVLAMAGLKRLGWLDQ 181 Query: 183 IR---AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 R L + LPA+ QGA+ +ECR +D LLAA+ +TA V ERA+ ++ Sbjct: 182 SRLHIQPLETSLCLPAISQGALAVECREEDEELLSLLAAVQDEKTAAEVAVERAVLAQMN 241 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 C PI ++A+ L A++ DG Q I +G QD +Q+ +L + GA Sbjct: 242 ADCTFPIAAFAQKNGQGYQLEAMLAKEDG-QCIFVSLQG--QDGQQLAEQAVRQLADKGA 298 >UniRef50_A0LRF1 Porphobilinogen deaminase n=1 Tax=Acidothermus cellulolyticus 11B RepID=HEM3_ACIC1 Length = 331 Score = 349 bits (897), Expect = 7e-95, Method: Composition-based stats. Identities = 128/313 (40%), Positives = 165/313 (52%), Gaps = 6/313 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +VLR+ TR+S LA Q + L A+ G VE+V + + GD D PL + G G+FV Sbjct: 8 SVLRLGTRRSTLARAQTEEIAGALRAA--GCRVEIVGIQSTGDRHADVPLHEFAGSGVFV 65 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 EL ALL D+ VHSMKD+P L + I R DPRDA V+ L LP G+ Sbjct: 66 AELRAALLRGEVDVVVHSMKDLPTAEIPELAIAAIPRRADPRDALVTGAGCRLAELPTGA 125 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 IVGT S RR QL RPDL IR +RGN+ TRL KL G Y A+I+A AGL RL Sbjct: 126 IVGTGSPRRAAQLRLLRPDLEIRPIRGNLDTRLGKLHAGGYAALIVAAAGLARLHRSEEA 185 Query: 184 RAALPPEISLPAVGQGAVGIECRLDD----SRTRELLAALNHHETALRVTAERAMNTRLE 239 P + LPA GQGA+ +ECR D R +LA L+ T VTAERA+ + Sbjct: 186 AEFFDPTVMLPAPGQGALAVECRRADIADGGRLAGILAGLDDPATRAAVTAERALLAAVG 245 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GC P+G+ + + L A+V P G+ R G P DA +G LA +L+ GA Sbjct: 246 AGCSAPVGALGVVTADTLQLDAVVVDPSGTTAFRRSLTGTPDDASDLGRRLAADLIRAGA 305 Query: 300 REILAEVYNGDAP 312 ++L P Sbjct: 306 DQLLQAPKQTGEP 318 >UniRef50_C6WZF5 Porphobilinogen deaminase n=1 Tax=Flavobacteriaceae bacterium 3519-10 RepID=C6WZF5_FLAB3 Length = 311 Score = 348 bits (895), Expect = 1e-94, Method: Composition-based stats. Identities = 107/309 (34%), Positives = 172/309 (55%), Gaps = 7/309 (2%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 ++I TR SPLALWQA V L + ++ P++++GD L PL +G G+ Sbjct: 8 SMRSIKIGTRNSPLALWQAREVARHLQNN--NHTTDITPIISKGDKNLSQPLYTLGITGI 65 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F K+L++ALL N DIAVHS+KD+P + P+ + ++ + +R+ P+D V + L Sbjct: 66 FTKDLDIALLNNEVDIAVHSLKDIPTQLPENVEIIAVLQRDYPQDVLVRKKDAATLELHQ 125 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 + TSSLRR+ + P +RGNV TRL+KL+ ++DA + ++A ++R+GL Sbjct: 126 -LKIATSSLRRRAFWLKEFPGTEFSDIRGNVQTRLTKLEENDFDATMFSLAAIERMGLSV 184 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + +PA QG V + R +D +EL +NH ET + + ER+ + LEGG Sbjct: 185 DYEH---LPLMIPAPAQGVVAVCARSNDPEIKELFKEINHRETRICIDIERSFLSTLEGG 241 Query: 242 CQVPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 C PIG++AE+ D GE+ + + DG I + A + + G LAE++L NG R Sbjct: 242 CTAPIGAFAEINDLGEVRFTGRICSLDGQNCIETDEIFAWNEHDDFGKILAEKILQNGGR 301 Query: 301 EILAEVYNG 309 E++ E+ + Sbjct: 302 ELMQEIKSK 310 >UniRef50_C3PNS9 Porphobilinogen deaminase n=15 Tax=Rickettsia RepID=HEM3_RICAE Length = 351 Score = 347 bits (892), Expect = 3e-94, Method: Composition-based stats. Identities = 115/348 (33%), Positives = 173/348 (49%), Gaps = 52/348 (14%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + N +RI TR+SPLAL + V ++ P + E+VP++T GD+I + PL +GGK L Sbjct: 1 MTNSIRIGTRKSPLALIHTNLVIQQIKQFFPDINCEIVPIITSGDLIQNKPLYDIGGKAL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F+KE+E ALL+ + D+AVHS+KDVP P+ L + + EREDPRD FV Y S++ LP Sbjct: 61 FLKEIEQALLDKKIDLAVHSLKDVPGRIPEPLVIAAVLEREDPRDVFVCLKYKSIEELPQ 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG-LE 180 +++G+S++RR+ + + RPDL + RGNV +R+ KL GE DA ILA GLKRL Sbjct: 121 NAVIGSSAVRRKAFIQKIRPDLKVTVFRGNVDSRIKKLMTGEVDATILAYTGLKRLEVFN 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 + LP +GQG + +E R DD+ E+ +NH T + ERA L+ Sbjct: 181 PEYCHLIEYSQMLPCIGQGVIAVEIRKDDNAMLEICNQINHLPTFELIKPERAFLEYLDA 240 Query: 241 GCQVPIGSYAELID---------------------------------------------- 254 C+ PI +Y++ +D Sbjct: 241 NCRTPIAAYSQYLDANPRHLSKLAYREVFEGNTEALATAAYKSNRTDVSTGLTYKLPLEV 300 Query: 255 -----GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 I ++G DGS+I + + + GI A+ +L Sbjct: 301 EFGKVSNIQTNFMLGNLDGSKITFHTETTNIKTSTEAGIKAAKMMLEA 348 >UniRef50_A3ZKX4 Porphobilinogen deaminase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A3ZKX4_9PLAN Length = 308 Score = 346 bits (889), Expect = 6e-94, Method: Composition-based stats. Identities = 133/308 (43%), Positives = 185/308 (60%), Gaps = 5/308 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LA WQA++V D+L A G VE++ + T+GDV PL +GG+G+F E Sbjct: 4 IRIGTRGSQLAQWQANWVADQLRAV--GTDVEIIHIATQGDVTQG-PLDLIGGRGVFTTE 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 ++ ALL+NR D+AVHS+KD+P E GL L + R D +++ + LP SI+ Sbjct: 61 IQAALLDNRIDVAVHSLKDLPTEAVVGLRLAAVPARGADGDVLITSKASDVLGLPQESII 120 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT S+RR+ QL R D IR +RGN+ TRL KLD+G YDAIILA AGL+RL L RIR Sbjct: 121 GTGSMRRKAQLLHLRRDFQIRDIRGNLDTRLRKLDDGLYDAIILAEAGLRRLELIERIRH 180 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 +P LPAVGQGA+G+E R DS T +LA LNH ++ V AER+M L GGC P Sbjct: 181 VIPKAQMLPAVGQGALGLEIRERDSATAAMLAPLNHEDSHYSVLAERSMLRNLRGGCLAP 240 Query: 246 IGSYAELI--DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 +G++ + ++L +V + DG + G P AE +G +A++L GA ++ Sbjct: 241 VGAWGRIDPIKQLLFLDGVVVSGDGHHKVTASACGPPNRAEDIGRQVADQLAIQGAERLI 300 Query: 304 AEVYNGDA 311 A + Sbjct: 301 AFARATGS 308 >UniRef50_A8MDU3 Probable porphobilinogen deaminase n=2 Tax=Thermoproteaceae RepID=HEM3_CALMQ Length = 305 Score = 346 bits (888), Expect = 8e-94, Method: Composition-based stats. Identities = 124/303 (40%), Positives = 179/303 (59%), Gaps = 2/303 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RIATR S L+L Q V D+++ + + +L+ + T GDV L PL ++G KG+F +E Sbjct: 3 IRIATRGSALSLKQTKIVMDRILEFNKDVEFKLIIVKTTGDVDLSKPLYEIGVKGIFERE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 + A+L AD+AVHS+KD+P + L LV R++PRDA VS ++D LP SIV Sbjct: 63 VNQAVLRGEADVAVHSLKDMPAQISNDLTLVMTPPRDNPRDALVSLRQYTVDTLPLNSIV 122 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR+ L R D+ ++ +RGNV TR+ KL+NGEYDA+I+A AGL+RL + + + Sbjct: 123 GTSSLRRRGFLLSLRRDVTVKPIRGNVDTRIRKLNNGEYDALIMAAAGLERLSINANVSE 182 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 + PE+ PA GQG +G+ R D ++L + ET AERA +R+ GC VP Sbjct: 183 -ISPELMPPAPGQGIIGVVARRDRDDLIKVLRRSSDEETFKEAAAERAFLSRIGAGCHVP 241 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 +G A L DG V PDG + R ++ E+ G AE+LL N AR ++A Sbjct: 242 LGGLALLDDGYFDFTYGVVDPDGVEKFINSTRIDARNPEEAGRVAAEDLLRN-ARGLVAR 300 Query: 306 VYN 308 + Sbjct: 301 LLK 303 >UniRef50_A2Q9P7 Catalytic activity: 4 porphobilinogen+H(2)O<=>hydroxymethylbilane+4 NH(3) n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2Q9P7_ASPNC Length = 346 Score = 344 bits (884), Expect = 2e-93, Method: Composition-based stats. Identities = 122/335 (36%), Positives = 175/335 (52%), Gaps = 28/335 (8%) Query: 1 MLDNV------LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLA 54 M N LR+ TR S LAL QA +V +L ++HPG+ +V RGD +P Sbjct: 1 MSQNTTTTVQELRLGTRNSKLALVQAEHVSKELTSAHPGVQFPWQTVVVRGDADKSSPFL 60 Query: 55 KVGG-----KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV 109 K G K ++ +E+E L D+ VH +KD+P P+ L I REDP DA V Sbjct: 61 KFAGPSDAAKNIWTEEMETKLCAGELDLLVHCLKDMPTRLPETCTLGAIVYREDPTDALV 120 Query: 110 SNNY-----DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE- 163 L LP GS+VGTSS RR+ L R P L + RGN+GTRL KLD+ E Sbjct: 121 IKEGLRSQYTDLSQLPPGSVVGTSSTRRKALLRYRYPHLKVEECRGNLGTRLKKLDDPEG 180 Query: 164 -YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHH 222 + AIILA AG+ R+ LE RI LPP AVGQGA+GIE R +D++T+ ++ + Sbjct: 181 PFSAIILATAGMVRINLEDRITKRLPPSEFPYAVGQGALGIEIRKEDAQTKTMVRKIEDL 240 Query: 223 ETALRVTAERAMNTRLEGGCQVPIGSYAELID-------GEIWLRALVGAPDGSQIIRGE 275 T AER++ L+GGC P+ + + ++ L + P G+ ++ Sbjct: 241 VTRRICLAERSLLRTLQGGCSSPVAVHCTVEQAPTASSPAQLRLDGTIIHPHGTTLLSER 300 Query: 276 RR---GAPQDAEQMGISLAEELLNNGAREILAEVY 307 G +DAE +G ++A++LL NG + +L E+ Sbjct: 301 TTAEVGTDEDAEALGATVAQQLLKNGGQALLEEIR 335 >UniRef50_C0YV01 Hydroxymethylbilane synthase n=1 Tax=Chryseobacterium gleum ATCC 35910 RepID=C0YV01_9FLAO Length = 302 Score = 344 bits (883), Expect = 2e-93, Method: Composition-based stats. Identities = 110/306 (35%), Positives = 167/306 (54%), Gaps = 6/306 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +RI TR S LALWQA V L + + E+VP+V+ GD L+ PL +G G+F Sbjct: 2 KSIRIGTRNSALALWQAREVARHLQNN--NYLTEIVPIVSSGDKNLNQPLYSLGITGVFT 59 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 ++L++ALL + DIAVHS+KDVP + PQ + ++ ER+ P+D + Sbjct: 60 RDLDIALLNDEIDIAVHSLKDVPTQLPQNIEMIAYLERDYPQDILIRKESSRNKEFHE-L 118 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 + TSSLRR+ P +RGN+ TRL KL+ G++DA IL++AG+KR+ +E Sbjct: 119 KLATSSLRRRAFWLRNYPTAEFSDIRGNIQTRLQKLEEGDFDATILSLAGIKRMKMEIDY 178 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 LP + A QG + + D E++ +NH ET + V ER + LEGGC Sbjct: 179 -EMLPL--MISAPSQGVISVAGHTDKPEINEIVRQINHQETQICVEIERNFLSTLEGGCT 235 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 PIG++AE+I +I +A + + DG I + AE G A+ +L NG +E++ Sbjct: 236 APIGAFAEIIGDQIRFKAALCSLDGKNCIAVDENFVYTPAENFGEKYAKVVLENGGKELM 295 Query: 304 AEVYNG 309 AE+ + Sbjct: 296 AEIKSQ 301 >UniRef50_C4ZFT9 Porphobilinogen deaminase n=1 Tax=Eubacterium rectale ATCC 33656 RepID=C4ZFT9_EUBR3 Length = 338 Score = 344 bits (883), Expect = 3e-93, Method: Composition-based stats. Identities = 113/309 (36%), Positives = 160/309 (51%), Gaps = 39/309 (12%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67 I TR S LAL Q YV DKL ++P + V + T GD+ L K+G KG+FVKE+E Sbjct: 5 IGTRGSKLALVQTDYVIDKLKRAYPDDDFKAVIIKTTGDLEQKKALDKIGSKGIFVKEIE 64 Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127 LL + +AVHSMKD+P E GL +REDPRD V N SLD LP G+++GT Sbjct: 65 DELLSGKIHMAVHSMKDMPDEPAAGLTFAKAWKREDPRDVLVLKNAASLDELPHGAVIGT 124 Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE------------------------ 163 S RR+ QL + RPDL + +RGN+ TRL KL +GE Sbjct: 125 GSKRRKYQLLKLRPDLKVVGIRGNIDTRLRKLYDGEIIYEEVADNTVNNNEIANEKKNKY 184 Query: 164 ----YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAAL 219 D I+LA AG+KR+G +S I + +PA QG + +E R D+++ L AL Sbjct: 185 SEYRLDGIVLAAAGIKRIGRDSEITQYFSEDDMIPAPAQGTLALELRADNAKLMAKLDAL 244 Query: 220 NHHETALRVTAERAMNTRLEGGCQVPIGSYAEL-----------IDGEIWLRALVGAPDG 268 + +T L ER ++ G C +P+ +Y ++ + + L A+ G+ DG Sbjct: 245 SDEKTNLCAGIEREFLKQIGGNCHLPVAAYCDIVSEKDRGNDSNKNNRLKLLAMFGSEDG 304 Query: 269 SQIIRGERR 277 Q+ R E+ Sbjct: 305 KQLARTEQV 313 >UniRef50_C1ZK04 Porphobilinogen deaminase n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZK04_PLALI Length = 318 Score = 342 bits (878), Expect = 9e-93, Method: Composition-based stats. Identities = 139/315 (44%), Positives = 181/315 (57%), Gaps = 16/315 (5%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 VLRIATR S LALWQA++V D L + P L VELV + T GD + PL + GG+G+F + Sbjct: 3 VLRIATRASQLALWQANFVADSLRSLDPELTVELVHVTTTGDRVQGEPLRQFGGQGVFTR 62 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY----DSLDALP 120 E++ ALLE RADIAVHS+KD+P GL L + R DA + SL LP Sbjct: 63 EVQAALLEGRADIAVHSLKDLPTVPTAGLELAAVPARAPVADALLLPTGHSGPASLAMLP 122 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GT S RRQ QL RPDL+ +RGN+ TR+ KLD GEY+ +ILAVAGL RLG Sbjct: 123 RGARIGTGSPRRQAQLLRIRPDLVCSEVRGNLDTRIRKLDAGEYEGLILAVAGLSRLGWS 182 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 RI L P PA GQGA+G+ECR D T ++ L +T L V AERA+ LE Sbjct: 183 DRISLILAPPTMFPAAGQGALGLECRHGDEATIRWVSQLEDRQTRLAVDAERAVLRTLEA 242 Query: 241 GCQVPIGSYAELID-GEIWLRALVGAPDGSQIIRG--ERRGAPQD---------AEQMGI 288 GC P+G++A + L A++ APDGS+ + +G A ++G Sbjct: 243 GCHAPVGTWASWKSPETLHLEAILIAPDGSETLAAASSMQGPLSQYGSGNALDAAHELGA 302 Query: 289 SLAEELLNNGAREIL 303 ++A LL GA L Sbjct: 303 NVAHLLLKQGASRYL 317 >UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia (class) RepID=B9L0Q4_THERP Length = 560 Score = 342 bits (878), Expect = 1e-92, Method: Composition-based stats. Identities = 125/295 (42%), Positives = 163/295 (55%), Gaps = 4/295 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + +RI +R S LAL Q V ++L P V +VP+VT GD T L +GG G+ Sbjct: 1 MAARIRIGSRGSTLALAQTEEVVERLRRLVPECSVTVVPIVTTGDRDRATSLTVLGGSGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F KEL ALL D+AVHS KD+P + P GL LV + RED RD V++ L LPA Sbjct: 61 FAKELHEALLAGTIDLAVHSAKDLPTQLPPGLVLVAVLAREDARDVLVTSPPRKLGELPA 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ VGTSS RRQ L RPDLI+ +RGNV TRL KL G DA++L AGL+RL Sbjct: 121 GARVGTSSRRRQALLQRARPDLIVVDIRGNVDTRLRKLREGIVDALVLGAAGLRRLSQAD 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + L P+ +PA GQGA+ + R D R ELL+ L+ V ERA G Sbjct: 181 LVAEYLDPDEFVPAPGQGALAVVARESDGRL-ELLSRLDEPLVHEAVAVERAFLAAFGSG 239 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDG---SQIIRGERRGAPQDAEQMGISLAEE 293 C VP+G+YA + + R V PDG SQ + R A + A ++G++LA Sbjct: 240 CSVPLGAYATIAGNRLRFRIAVLLPDGRFISQCLDWPREEAIERARELGLTLATR 294 >UniRef50_A2BL26 Probable porphobilinogen deaminase n=2 Tax=Thermoprotei RepID=HEM3_HYPBU Length = 303 Score = 342 bits (877), Expect = 1e-92, Method: Composition-based stats. Identities = 127/299 (42%), Positives = 168/299 (56%), Gaps = 3/299 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LR+ATR S L++ Q + + P L ELV + TRGD+ D P +GGKGLF K Sbjct: 2 KLRVATRGSKLSIAQTMIALEAIKRVEPSLEYELVIVKTRGDIHQDKPFTAIGGKGLFEK 61 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY--DSLDALPAG 122 E+ +A+LE RADIAVHS+KDVP GL L R+ P D V ++ LP+G Sbjct: 62 EVNLAVLEGRADIAVHSLKDVPSAISPGLVLAMTPPRDPPYDVLVVRGGKEKTIWDLPSG 121 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 +IVGTSS RR L R DL+ + LRGNV TRL KL+ G+YDAI+LA AGLKRLG++ Sbjct: 122 AIVGTSSARRVAMLKHVRRDLVFKVLRGNVDTRLRKLEQGQYDAIVLAEAGLKRLGVDIE 181 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 +PP+I PA GQG +G+ S +L + + AERA GGC Sbjct: 182 YWR-IPPDILPPAPGQGIIGVYTLSSRSDILPILEKASDQKAMAEARAERAFLAYAGGGC 240 Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 P+G+YAEL ++ A + +PDGS+ + G P Q+G+ A EL ARE Sbjct: 241 HTPLGAYAELRGNTLYFHAALASPDGSRRVEVRVEGDPDKPTQVGLEAAFELRRLAARE 299 >UniRef50_Q0TQG4 Porphobilinogen deaminase n=32 Tax=Clostridium RepID=HEM3_CLOP1 Length = 291 Score = 342 bits (877), Expect = 1e-92, Method: Composition-based stats. Identities = 128/292 (43%), Positives = 170/292 (58%), Gaps = 4/292 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L IATR+S LA Q V + L + + + ++T GD LD L K+GGKGLFVKE Sbjct: 3 LIIATRKSKLAQVQTEKVMELLKEKE-NVDSKKLLVMTEGDRRLDVSLNKIGGKGLFVKE 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E+ALL A AVHSMKDVP E P LV + ERED RDAFVS N +L L G+ + Sbjct: 62 IELALLNKEAHGAVHSMKDVPFELPSEFELVAMPEREDIRDAFVSLNGSTLSNLRKGARI 121 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR QL R DL I +RGNV TR+ K+ D IILA AGLKRLG+E I Sbjct: 122 GTSSIRRAEQLKLFRDDLEIVPIRGNVQTRIKKITEENLDGIILAAAGLKRLGMEDVISD 181 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 P++ LPA+GQGA+GIEC + AL+ E V AER+ L GGC Sbjct: 182 YFDPKVFLPAIGQGALGIECLKGGEF-NDYFKALDSKEVRTTVEAERSFMKVLNGGCHSL 240 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 IG+Y+E+ D ++++ + +I++ + G +D +G LAE++L Sbjct: 241 IGAYSEVKDNDLYMIGTFTVNN--RIVKKDILGNKEDNILLGKKLAEKILGE 290 >UniRef50_B3DZQ6 Porphobilinogen deaminase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DZQ6_METI4 Length = 298 Score = 341 bits (876), Expect = 2e-92, Method: Composition-based stats. Identities = 114/296 (38%), Positives = 164/296 (55%), Gaps = 3/296 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L I +R S LAL QA + D L +P L +++ + T GD + P+ + +G+F Sbjct: 2 KPLIIGSRGSRLALIQAQLIVDSLKKEYPLLDIQIRVIKTTGDHLEAQPIRDIDQRGIFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE+E LLE D+AVHS+KD+ VE L + I REDPRD ++S + +L AG+ Sbjct: 62 KEIENKLLEGEIDLAVHSLKDLQVELHPRLVIAAIPPREDPRDCWISLQHPHPSSLQAGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG-EYDAIILAVAGLKRLGLE-- 180 IV T S RR QL +RPDL I +RGNV +RL KL ++ +LA+AG+KRLG++ Sbjct: 122 IVVTGSPRRANQLLRKRPDLRIVPVRGNVESRLRKLRENRQWQGTVLALAGIKRLGIDIS 181 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 S L + LPA GQGA+ ++ R++D T+ L+ LN TA VTAER L G Sbjct: 182 SFFCTPLSMDWMLPAPGQGALALQARIEDKHTQSLVKHLNDFSTACAVTAERVFLHELGG 241 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 GC+ +G+ AE+ + L + + G+ G AE +G LA+ L N Sbjct: 242 GCRTAVGARAEVEGSRLVLEGIWWPQQAIEPKEGKVVGEIHRAEDLGKKLADLLKN 297 >UniRef50_Q0BX92 Porphobilinogen deaminase n=1 Tax=Hyphomonas neptunium ATCC 15444 RepID=HEM3_HYPNA Length = 321 Score = 341 bits (876), Expect = 2e-92, Method: Composition-based stats. Identities = 120/298 (40%), Positives = 166/298 (55%), Gaps = 7/298 (2%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPG-LVVELVPMVTRGDVILDTPLAKVGGKGLF 62 LR+ TR SPLAL QAH + D + A+ G E+V T GD + L GGKGLF Sbjct: 11 KRLRLGTRGSPLALAQAHQIADGIRAASAGAYDCEIVAFTTTGDKLTTERLINSGGKGLF 70 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 +EL+ AL D+AVHS+KDVP P G +REDPRD F+S+ S+ LP G Sbjct: 71 TRELDDALSRGELDLAVHSLKDVPSVLPPGQIFAAFPKREDPRDGFLSHGAKSIQDLPEG 130 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 + +GT+SLRR+ Q RPDL + + RGNV TR+ KL+ G DA LA+AGL RLGL Sbjct: 131 ATLGTASLRREAQALALRPDLKVVTFRGNVATRMRKLEEGLADATFLAMAGLTRLGLSEV 190 Query: 183 IRAALPPEISLPAVGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 +P E LPA GQG +G+ R D D+ E+L L+H + + AERA +L+G Sbjct: 191 AT-PIPLEDMLPAAGQGIIGVVTRDDVDTELLEILGQLSHEPSRVAAIAERAFLEKLDGS 249 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQ----MGISLAEELL 295 C+ PI ++ E L V +P G+ RG+ + +G ++A+E++ Sbjct: 250 CRTPIAAHLFDRGDEWQLIGEVLSPGGTTRWRGDGVCRKDATDAQLVLLGRAVAQEII 307 >UniRef50_A5CDH4 Porphobilinogen deaminase n=2 Tax=Orientia tsutsugamushi RepID=HEM3_ORITB Length = 298 Score = 340 bits (873), Expect = 4e-92, Method: Composition-based stats. Identities = 124/294 (42%), Positives = 160/294 (54%), Gaps = 3/294 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +R+ +R S LAL QA V K+ GL ++P+ T GD+I + L +GGKGLF+KE Sbjct: 3 IRVGSRASRLALIQAQAVVQKINDLL-GLNAIIIPIKTTGDLIQNKNLYDIGGKGLFLKE 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E ALL N DIAVHS+KDVP P GL L + ER D D VS + + LP G+IV Sbjct: 62 IEYALLNNTIDIAVHSLKDVPAYLPDGLQLAAVLERGDVGDMLVSKIANKITDLPLGAIV 121 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE-SRIR 184 GTSS+RR+ QL RPDL I RGNV TR +K+ N E DA +LA AGL+RL + SR Sbjct: 122 GTSSVRRRIQLLMLRPDLNIVLFRGNVDTRWNKIINNEVDATVLAAAGLQRLNYDTSRFC 181 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 +P LPA+GQGA+ IE R DD L A +NH T + ER L C V Sbjct: 182 NIIPQSEMLPAIGQGAIAIEARKDDKLIMPLCAKINHQLTWQLIQVERGYLKTLNADCNV 241 Query: 245 PIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 PIG A I + ++G + E RG Q +G+ A+ Sbjct: 242 PIGGIASYIGNNSFEAKFMLGDYNMRYFFYSEVRGKLQHGYDIGVEAAKNFQKR 295 >UniRef50_B8MVK7 Porphobilinogen deaminase, putative n=1 Tax=Talaromyces stipitatus ATCC 10500 RepID=B8MVK7_TALSN Length = 413 Score = 338 bits (868), Expect = 2e-91, Method: Composition-based stats. Identities = 120/341 (35%), Positives = 169/341 (49%), Gaps = 36/341 (10%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGL-VVELVPMVTRGDVILDTPLAKVG----- 57 +R+ +R S +AL Q V L +H G + +GD + + Sbjct: 72 KAVRVGSRNSKMALIQTSSVAAALYKAHHGFFTFPVSTHSVQGDRDKTSAFRDLAKAHGN 131 Query: 58 -------GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS 110 K L+ E+E LL D+ VHS+KDVP P G + R DP DA + Sbjct: 132 KQTAADTAKSLWTLEIEARLLAGDIDLIVHSLKDVPTTLPDGCEIGAFPHRNDPTDALLV 191 Query: 111 N---NYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YD 165 Y SL+ LPAGS+VGT S+RR QL P LII+ RGNV TR++KLD + Y Sbjct: 192 KAGLPYKSLEELPAGSVVGTCSVRRTAQLRHYCPHLIIQECRGNVDTRVAKLDANDSPYT 251 Query: 166 AIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETA 225 AI++A AG+ RL LE RI L AVGQGA+GIE R +D + REL+A ++H T Sbjct: 252 AIVVAAAGIVRLNLEHRITQRLSGPAYTYAVGQGALGIEIRKEDQKARELVACIDHWPTR 311 Query: 226 LRVTAERAMNTRLEGGCQVPIGSYAEL---------------IDGEIWLRALVGAPDGSQ 270 +R AERA+ L+GGC PIG ++ +G ++L + PDG Sbjct: 312 VRCLAERALLRFLQGGCSAPIGVHSAFVRTPAKGEPNVNDNHYEGTLYLTGTLLHPDGGM 371 Query: 271 IIRGERRGAP---QDAEQMGISLAEELLNNGAREILAEVYN 308 IR +G D+E +G S+ +++L+ G +IL Sbjct: 372 EIRAHEKGQVKCTADSETIGKSVGKKILDLGGAQILDIFKA 412 >UniRef50_C1F251 Hydroxymethylbilane synthase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F251_ACIC5 Length = 312 Score = 337 bits (866), Expect = 2e-91, Method: Composition-based stats. Identities = 139/322 (43%), Positives = 176/322 (54%), Gaps = 37/322 (11%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLA----KVGGKGL 61 +RI +R S LALWQA+++ +L G V + + T GD + A ++GGKG+ Sbjct: 2 MRIGSRGSQLALWQANHIAARLRTL--GHEVTIEIIRTTGDALQHVTFAKVSTELGGKGI 59 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F KE+E AL E R D+AVHS+KD+P + L I ER DPRDA +S Y SL +LP Sbjct: 60 FTKEIEEALREGRIDLAVHSLKDLPTDLDPAFTLAAIPERVDPRDALLSARYTSLASLPH 119 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ VGTSS RR+ QL R DL + RGNV TR+ K+ G+ DAIILA AGL+RLGL Sbjct: 120 GACVGTSSERRRAQLLVHRSDLRFQEFRGNVDTRIRKMVEGQADAIILASAGLERLGLTE 179 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 R L PEI PA GQGA+ IE R DD+ T +LA+L+H T VTAER L GG Sbjct: 180 YRRECLAPEILCPAAGQGALAIETRADDAETLAILASLDHSATRYAVTAERTALASLGGG 239 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ-------------------- 281 CQVPIG + A V DG+ I+G GA Sbjct: 240 CQVPIGIHC----------APVPGADGAYAIQGVVAGAAAKAASSAAHPVIRVAFEHQQG 289 Query: 282 -DAEQMGISLAEELLNNGAREI 302 + +G LAEELL GA+ Sbjct: 290 LSPQALGRQLAEELLRQGAQPF 311 >UniRef50_Q09899 Porphobilinogen deaminase n=2 Tax=Schizosaccharomyces RepID=HEM3_SCHPO Length = 336 Score = 337 bits (865), Expect = 3e-91, Method: Composition-based stats. Identities = 126/314 (40%), Positives = 176/314 (56%), Gaps = 16/314 (5%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG---GKGLFVK 64 I TR+S LA+ Q+ ++++L +P L ++ T GD IL L + K L+ + Sbjct: 9 IGTRKSKLAVIQSEIIREELEKHYPHLEFPIISRDTIGDEILSKALFEFKRQLAKSLWTR 68 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALPA 121 ELE L+ N+ I VHS+KD+P E P G+ + I +R P DA V +Y ++ LP Sbjct: 69 ELEALLVTNQCRILVHSLKDLPSEMPDGMVIACIPKRSCPLDAIVFKAGSHYKTVADLPP 128 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAGLKRLGL 179 GS+VGTSS+RR+ LA P L +RGNVGTRL+KLD + +D ++LA AGL RLGL Sbjct: 129 GSVVGTSSIRRRALLARNFPHLRFVDIRGNVGTRLAKLDAPDSQFDCLVLAAAGLFRLGL 188 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 + RI L AVGQGA+ +E R DD E+L L H ET AERA+ RL+ Sbjct: 189 KDRIAQMLTAPFVYYAVGQGALAVEVRADDKEMIEMLKPLQHQETLYACLAERALMKRLQ 248 Query: 240 GGCQVPIGSYAEL-----IDGEIWLRALVGAPDGSQIIRGE---RRGAPQDAEQMGISLA 291 GGC +PIG ++ I L V + DG + G + ++AE++GI++A Sbjct: 249 GGCAIPIGVQTDVLAISNSSYRISLLGTVLSADGLRAAFGNAEAVVSSEEEAEELGITVA 308 Query: 292 EELLNNGAREILAE 305 LL NGA IL E Sbjct: 309 LALLKNGAGPILEE 322 >UniRef50_C7NFP7 Hydroxymethylbilane synthase n=7 Tax=Actinomycetales RepID=C7NFP7_KYTSD Length = 358 Score = 337 bits (864), Expect = 4e-91, Method: Composition-based stats. Identities = 134/329 (40%), Positives = 180/329 (54%), Gaps = 33/329 (10%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 V+R+ TR+S LA Q+ +V D L A G VELV + T GDV PL+++GG G+FV Sbjct: 14 RVVRLGTRRSDLATTQSTHVADALRAR--GHEVELVLVTTEGDVNR-APLSRIGGTGVFV 70 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 L ALL DIAVHS+KD+PV PQ L + + EREDPRDA V+ + +L+ LPAG+ Sbjct: 71 SALRDALLAGEIDIAVHSLKDLPVAQPQELVIAAVPEREDPRDALVARDGLTLETLPAGA 130 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGT S RR+ QL RPDL + LRGNV RL+ + GE DA++LA AGL+RLGL + Sbjct: 131 RVGTGSPRREAQLRVARPDLEVVDLRGNVPRRLATVAEGELDAVVLAGAGLRRLGLTEHV 190 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 L P++ +PA GQGA+ +ECR DD+ + +L L+H T TAERA+ LE GC Sbjct: 191 TQWLEPQVMVPAPGQGALAVECRSDDAESIAMLEPLDHLPTRTATTAERAVLGTLEAGCS 250 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQII------------------------------R 273 PIG+ A + L G DGS+ + Sbjct: 251 APIGALARHDGARVDLMTFAGPRDGSRALLEADCARGVPAGHPADTPDDTPADTPDDSRN 310 Query: 274 GERRGAPQDAEQMGISLAEELLNNGAREI 302 +R A ++G +AE L GA + Sbjct: 311 DDRVALDTAARELGRRVAEALRGGGADVL 339 >UniRef50_B0D5Q2 Predicted protein n=1 Tax=Laccaria bicolor S238N-H82 RepID=B0D5Q2_LACBS Length = 340 Score = 337 bits (864), Expect = 5e-91, Method: Composition-based stats. Identities = 118/317 (37%), Positives = 172/317 (54%), Gaps = 10/317 (3%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + I R S LA QA V+ +L P E+ I + + + GG L+ Sbjct: 16 QKAIVIGCRPSTLAKIQAELVRSRLKVLFPASRFEISSKKFPQPEIGTSQITERGGASLW 75 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLDAL 119 ELE AL + DI VHS+KDVP + +G ++ + ERED RD V + +L+ L Sbjct: 76 TTELEDALFDGDIDILVHSLKDVPTKLKEGCEIIHVLEREDRRDCLVVKDGLPYRTLEEL 135 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAGLKRL 177 PAGS+VGT S+RR Q+ R P L+I+ +RGN+ TRL KLD+ + Y A+ILA AGL RL Sbjct: 136 PAGSVVGTGSVRRVAQMKRRYPLLVIKDVRGNIDTRLQKLDSPDLPYTALILASAGLLRL 195 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 L RI + L P IS PAVGQG +G E R D++ + +++ L + V AERA+ Sbjct: 196 SLHDRITSYLSPPISYPAVGQGCLGAEFRSADTKVKAMVSRLEVWQDGWAVRAERALLWV 255 Query: 238 LEGGCQVPIGSYAELIDGEI--WLRALVGAPDGSQIIRGERRG---APQDAEQMGISLAE 292 LEGGC P+G ++ I +++ +PDGS+ I E G + ++ ++G A Sbjct: 256 LEGGCAFPVGIWSSWSGDNIASESLSVMTSPDGSEEITVETTGVVASVEEVLELGKQAAR 315 Query: 293 ELLNNGAREILAEVYNG 309 LL G R I+ ++ Sbjct: 316 SLLEKGGRGIIVDLRAE 332 >UniRef50_C8WIZ2 Porphobilinogen deaminase n=2 Tax=Coriobacteriaceae RepID=C8WIZ2_EGGLE Length = 327 Score = 336 bits (863), Expect = 5e-91, Method: Composition-based stats. Identities = 137/318 (43%), Positives = 183/318 (57%), Gaps = 13/318 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LALWQAH+V D L A+ PG+ V + + T+GD IL L+K+G KGLF KE Sbjct: 4 MRIGTRGSKLALWQAHHVADLLRAASPGMDVSVEVVKTKGDRILGVALSKIGDKGLFTKE 63 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE AL + R D+ VHSMKDVP P+GL L R D RD V+ + + LPAGS V Sbjct: 64 LEQALFDGRVDVCVHSMKDVPTALPEGLALAGCLIRADARDVLVAASGTTFAGLPAGSRV 123 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT +LRR QL R DL +RGN+ TR++K+ +G DA++LA AG++R+G + + Sbjct: 124 GTGALRRLSQLRAVRDDLDYVEVRGNLDTRIAKVRDGALDAVVLAAAGIERMGWSAEVAE 183 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 A + +PAVGQGA+G+E R DD RT A + T V AER + L+GGCQVP Sbjct: 184 AFSVDTVVPAVGQGAIGLEVRADDERTARACAQVRCAATDACVAAERHVMRALDGGCQVP 243 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGE-------------RRGAPQDAEQMGISLAE 292 IG+YA +G + L A VG+ DGS ++R A ++A + E Sbjct: 244 IGAYARYEEGLLVLDAFVGSLDGSHVLRSRLSAASQPPNDTDAVEAAVREARALAQRAVE 303 Query: 293 ELLNNGAREILAEVYNGD 310 E GAR +L V Sbjct: 304 EFEAQGARAVLDAVRAAG 321 >UniRef50_A4XK06 Porphobilinogen deaminase n=2 Tax=Clostridia RepID=HEM3_CALS8 Length = 290 Score = 335 bits (861), Expect = 9e-91, Method: Composition-based stats. Identities = 101/293 (34%), Positives = 152/293 (51%), Gaps = 4/293 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 LRI R S L+ Q V K+ G+ E VP+ T+GD+ L G+FV Sbjct: 2 KKLRIGARDSKLSRIQVDIVARKIK-QTLGIECEFVPIKTKGDIDKTKSLKDFKSPGVFV 60 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE+E+ALL D+AVHS+KD+P E +V + EREDPRD VS + L + Sbjct: 61 KEIELALLSREIDLAVHSLKDLPCEMDSNFEIVAVVEREDPRDVLVSKDGVGFYQLKPNA 120 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +GTSSLRR+ L R D+ + ++RGN+ TRLSK+++ D ++LA A LKRL L+S + Sbjct: 121 KIGTSSLRREVHLKNLRQDIQVVNIRGNIETRLSKIESEGLDGVVLAYAALKRLNLDSHV 180 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 P GQGA+ IEC D + +L+ +N + ++ ER + L GGC Sbjct: 181 SYIFDVNEITPCPGQGAICIECLKDSP-YKNILSKINDADAYIQTQFERLVLKFLGGGCH 239 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 IG + + +I+ A + + G ++I+ G D + L+ L + Sbjct: 240 SSIGVFCKTDQDKIYAFASILS--GDKLIKASIEGDKDDFLSLANKLSNMLKS 290 >UniRef50_B5G8F1 Porphobilinogen deaminase n=1 Tax=Streptomyces sp. SPB74 RepID=B5G8F1_9ACTO Length = 314 Score = 335 bits (861), Expect = 9e-91, Method: Composition-based stats. Identities = 128/314 (40%), Positives = 172/314 (54%), Gaps = 13/314 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR SPLAL Q V L P L +E+VP+ T+ D LA++GGKGLFV+E Sbjct: 1 MRIGTRSSPLALAQVEQVSGLLRKFEPDLDIEVVPVTTKADKWQGD-LAQLGGKGLFVRE 59 Query: 66 LEVALLENRADIAVHSMKDVP--VEFPQGLGLVTICEREDPRDAFVSNNY---DSLDALP 120 ++ L + D+AVH MKDVP V P+GL R+D RD + SL LP Sbjct: 60 IDQMLQRGQVDMAVHCMKDVPGDVPMPRGLIFAAYLPRDDVRDVLLVPEGSDVQSLAGLP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD-----NGEYDAIILAVAGLK 175 G+ V TS++RR+ Q+ RPDL + +RG VG+R+ KLD + DA++LA AGL+ Sbjct: 120 PGASVATSAVRRKAQINRVRPDLNVVRVRGLVGSRIDKLDGRKPMDHMLDAMVLARAGLE 179 Query: 176 RLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235 RL L R R LPAVG GA+G+ECR DD LL LN T +TAER M Sbjct: 180 RLDLMHRARQVFEVAEMLPAVGAGALGLECREDDDAVAYLLQQLNDEPTMTEITAERVML 239 Query: 236 TRLEGGCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRG-APQDAEQMGISLAEE 293 L G C PI + DG++ LR +V + DGS+ + G + D +G + E Sbjct: 240 HGLRGHCNSPIAGHCVTDPDGQLSLRGMVFSRDGSKFVHAHFWGESMNDPAVLGSRVCAE 299 Query: 294 LLNNGAREILAEVY 307 LL GAR+I+ + Sbjct: 300 LLRQGARDIIEGIP 313 >UniRef50_D0J8N1 Porphobilinogen deaminase n=2 Tax=Blattabacterium RepID=D0J8N1_BLASP Length = 310 Score = 335 bits (860), Expect = 1e-90, Method: Composition-based stats. Identities = 99/312 (31%), Positives = 153/312 (49%), Gaps = 7/312 (2%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 ++ ++RI TR SPLA+ QA V+ L G L + + GD+I + PL K G+ Sbjct: 1 MNKIIRIGTRNSPLAISQAIEVQKVLHRL--GYCSHLFFIKSEGDLIQNIPLYKFKKVGI 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS-LDALP 120 F + L LL + D+AVHS+KDVP P+ + L +R D + + L Sbjct: 59 FTRNLTDVLLSGKIDMAVHSLKDVPTSLPEKIVLSAYLKRGSFSDLLIYQGSSNFLLNSK 118 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 +++ T SLRR+ R P I LRGN+ TRL KL N + I A GL+RLGL Sbjct: 119 IEAVIATGSLRRRAFWKNRYPHHTIVDLRGNINTRLKKLYNNSWKGAIFAKVGLERLGLL 178 Query: 181 SRI--RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 + + + +P+ GQG + + R D+ L L+ T L ER L Sbjct: 179 NDLEGFNFKVLDWMIPSPGQGIIVVSTRKDNEWIHYLTKELDDRNTRLSANIERQFLKTL 238 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GGC PIG++A + + I+ ++ + DG Q IR ++ G + +G A+E+L G Sbjct: 239 GGGCVTPIGAHAIIKNKIIYFTGILFSLDGMQKIRKKKIGT--NYNVIGYQCAKEILEEG 296 Query: 299 AREILAEVYNGD 310 ++IL + + Sbjct: 297 GKKILENMRIKN 308 >UniRef50_Q8TXC8 Probable porphobilinogen deaminase n=1 Tax=Methanopyrus kandleri RepID=HEM3_METKA Length = 298 Score = 335 bits (859), Expect = 2e-90, Method: Composition-based stats. Identities = 120/299 (40%), Positives = 172/299 (57%), Gaps = 3/299 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHP-GLVVELVPMVTRGDVILDTPLAKVGGKG 60 + +R+ATR S LA+ Q V + L P + VE+V +RGDV+ D PL K+G KG Sbjct: 1 MSETIRVATRSSRLAIIQTREVIELLERESPRDVEVEIVKTKSRGDVVRDRPLHKLGEKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 +FVKE++ +LE +ADIAVHS KDVP + + + R DPR+ VS + L LP Sbjct: 61 VFVKEVDRLVLEGKADIAVHSAKDVPSVVDYPVDVAAVPPRRDPRECLVSRHGG-LKELP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGTSS RR+ Q+ RPDL + +RGNV TR+SK+ EYDA +LA GL RLG+ Sbjct: 120 RGATVGTSSPRRRAQILLERPDLKVEPMRGNVDTRVSKVRRREYDAAVLAKVGLDRLGMT 179 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 S + PE +P GQGA+ I CR DD R + LL ++ ++ + V E+A+ L Sbjct: 180 SEVSEVYDPEEFVPPAGQGALMITCRKDDDRVKRLLEVVDDEKSRVEVETEKAVVRELGV 239 Query: 241 GCQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GC P+G + + L + DGS + RG+P+D + +S A E+L++G Sbjct: 240 GCSEPVGVHVRARDGDHVRLVLGLFEEDGSCGHVLKMRGSPEDVVREAVSQAREVLSDG 298 >UniRef50_A8SQW4 Putative uncharacterized protein n=1 Tax=Coprococcus eutactus ATCC 27759 RepID=A8SQW4_9FIRM Length = 350 Score = 334 bits (858), Expect = 2e-90, Method: Composition-based stats. Identities = 115/314 (36%), Positives = 164/314 (52%), Gaps = 26/314 (8%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 +++ TR S LAL Q V L P + ++V M TRGD L + GGK +F Sbjct: 39 KKTVKVGTRGSKLALAQTELVIKALNERFPQIDFQMVTMSTRGDRDTSRALLEFGGKAVF 98 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 V+E E A+L+ DIAVHS KD+P+E +GL + R P+D F+ + S D Sbjct: 99 VEEFEEAILKGDIDIAVHSAKDMPMEIMEGLTISGTLPRACPQDVFIYKSGRSFDR-NDS 157 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL--- 179 +VGTSSLRRQ Q+ + P+ + ++LRGNVGTR+ KL++GEYDAIILA AGL+RLG+ Sbjct: 158 FVVGTSSLRRQYQIRDMYPNAVCKNLRGNVGTRIQKLEDGEYDAIILAAAGLERLGVIED 217 Query: 180 -------------ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETAL 226 + L E LPA QG + IE R +++ A+N E Sbjct: 218 KGNDSTECFEVHKDELTFRYLSTESMLPAACQGIIAIETRTSGEAY-DMVRAINDTEAYT 276 Query: 227 RVTAERAMNTRLEGGCQVPIGSYAELIDGEIWL---RALVGAPDGSQ-----IIRGERRG 278 ++T ERA+ +RL GC PIG Y+EL + L + + D + I R G Sbjct: 277 QLTCERAVLSRLNAGCHEPIGVYSELKGKHMKLSLMKVDAASSDKEKDEEIQIHRKTVEG 336 Query: 279 APQDAEQMGISLAE 292 + EQ+ +L + Sbjct: 337 NTSEWEQLVEALIK 350 >UniRef50_B9XN63 Porphobilinogen deaminase n=1 Tax=bacterium Ellin514 RepID=B9XN63_9BACT Length = 332 Score = 334 bits (857), Expect = 2e-90, Method: Composition-based stats. Identities = 127/329 (38%), Positives = 173/329 (52%), Gaps = 38/329 (11%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG---K 59 + + IATR S LAL QA+ V + ++ P L +EL + T GD + LAK G K Sbjct: 6 NKPIFIATRGSALALAQANAVLSQCRSAFPKLDIELKIIKTTGDKLQKASLAKEGESLPK 65 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSL--- 116 GLF KELEVALL ADIAVHS+KD+P E P GL L + +R D RD V + + L Sbjct: 66 GLFTKELEVALLNGDADIAVHSLKDLPTELPTGLILGAVSKRADVRDVLVYRDAEYLRSQ 125 Query: 117 ---------------DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN 161 P G+ V TSS RR+ QL +R DL + +RGNV TRL KL N Sbjct: 126 PGKSNRRGFTPKLAIKDFPPGATVATSSTRRKAQLLAQRGDLNVVEIRGNVATRLEKLAN 185 Query: 162 -GEYDAIILAVAGLKRLGL--------------ESRIRAALPPEISLPAVGQGAVGIECR 206 E DA +LA AGL+RL E + L ++ LP VGQ A+G+E R Sbjct: 186 QPELDATVLAAAGLERLNFKITAEGKLAGEGIPEGLLATILDFDVMLPCVGQAALGMEIR 245 Query: 207 LDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAP 266 +D+R +E+ LNH ET V AER+ + + GGCQ P+ +YAE+ ++ +RA + Sbjct: 246 ENDARIQEICDRLNHPETHACVLAERSFLSGMGGGCQSPVAAYAEIAGDQLQMRA--ASF 303 Query: 267 DGSQIIRGERRGAPQDAEQMGISLAEELL 295 + R + +A +G LA +L Sbjct: 304 RETSARRAVGGKSINEAVALGQELAAKLK 332 >UniRef50_A8MGE4 Porphobilinogen deaminase n=30 Tax=cellular organisms RepID=HEM3_ALKOO Length = 296 Score = 334 bits (857), Expect = 3e-90, Method: Composition-based stats. Identities = 113/293 (38%), Positives = 160/293 (54%), Gaps = 5/293 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +R+ +R+S LA+ Q+ V + + P + +ELV M T GD+ LD L K+GGKGLF+K Sbjct: 2 KIRVGSRESKLAVKQSEIVIEAIRKYDPNIEIELVTMKTTGDIKLDQTLDKIGGKGLFIK 61 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 EL+ AL ++R DI VHS KD+P+ + L +V + +REDPRD V ++ Sbjct: 62 ELDQALYDDRVDITVHSFKDMPMAIDEYLPIVAVSKREDPRDVLVLPK--TVKEPDFSKP 119 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +G SS RR+ QL E P + +RGNV TRL KLD GE+ AI LA+AGLKRLGLE RI Sbjct: 120 IGCSSFRRKIQLQEIYPHCSVEPIRGNVLTRLEKLDRGEFSAITLALAGLKRLGLEERIS 179 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 LPA QG + ++ R L+ + E AER+ L GGC Sbjct: 180 RIFEVTEILPAACQGVIVVQARKGFD--VSFLSDFHDKEAWDISMAERSFVRTLNGGCSS 237 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 P+ +Y E+ D + L L S + + GA + E+MG +LA ++ Sbjct: 238 PVAAYGEIKDNYLTLTGLYVDSSNS-VHKKTITGARKQGEEMGFNLALQMKGE 289 >UniRef50_B8GXG1 Porphobilinogen deaminase n=8 Tax=Caulobacteraceae RepID=HEM3_CAUCN Length = 322 Score = 333 bits (856), Expect = 3e-90, Method: Composition-based stats. Identities = 132/315 (41%), Positives = 176/315 (55%), Gaps = 17/315 (5%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMAS----------HPGLVVELVPMVTRGDVILDTPLA 54 +RI R S L+L Q+ ++ ++ + L+P+VT GD I D L Sbjct: 6 PIRIGARGSKLSLAQSGLMQARIAHALGVPAGASKDEIEAAAPLIPIVTSGDRIQDRRLM 65 Query: 55 KVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD 114 ++GGKGLF KE+E ALL+ R D AVHS+KD+P E P GL L EREDPRDAF+S+ + Sbjct: 66 EIGGKGLFTKEIEEALLDGRIDCAVHSLKDMPAELPPGLVLAATPEREDPRDAFISHVCE 125 Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174 L+ LP G+ +GT+SLRRQ Q RPDL I LRGNV TRL+KL+ GE DAI+LA +GL Sbjct: 126 RLEDLPKGARLGTASLRRQAQALHVRPDLEIVMLRGNVDTRLAKLERGEADAILLAQSGL 185 Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234 RLGL R+ L P+ PA GQGA+ IE R +D L A+ +T + V AER Sbjct: 186 NRLGLGHLTRSWLDPDACPPAPGQGALVIETRAEDIG-APWLEAVRCRQTTIAVAAERGA 244 Query: 235 NTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE------RRGAPQDAEQMGI 288 LEG C+ IG+ A L + + PDG+Q R E +A G+ Sbjct: 245 LLALEGSCRTAIGARAILDGARLSMIVEALTPDGAQRFRREGDITLTGADDIAEARAFGL 304 Query: 289 SLAEELLNNGAREIL 303 +L E+ G I+ Sbjct: 305 TLGAEVRAAGGDAII 319 >UniRef50_Q82P95 Porphobilinogen deaminase 2 n=14 Tax=Actinomycetales RepID=HEM32_STRAW Length = 314 Score = 333 bits (856), Expect = 4e-90, Method: Composition-based stats. Identities = 124/305 (40%), Positives = 167/305 (54%), Gaps = 4/305 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI +R SP+AL Q V+ +L A HP E+V + T GD + L+KV GKG F KE Sbjct: 10 IRIVSRDSPMALAQVARVRAELAALHPRTRTEVVAVKTTGDKWMGD-LSKVDGKGAFTKE 68 Query: 66 LEVALLENRADIAVHSMKDVPV--EFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 ++ ALL AD+AVH +KDVP P G +R+D RDA V +LD LP G+ Sbjct: 69 VDAALLAGEADLAVHCVKDVPADRPLPAGTMFAAFLKRDDIRDALVHPGGLTLDELPPGT 128 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +GTSS+RR QLA P L RGN RL KL GE DA++LAV+GL+R+G E I Sbjct: 129 RIGTSSVRRVAQLAAAYPHLECVPFRGNANRRLEKLAAGEADALLLAVSGLERIGREDVI 188 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 L PE +P +G G + ++CR D+ E ++ L T TAER L+G C Sbjct: 189 TEVLEPETMMPPIGAGILALQCREGDTGLIETISELGDPGTHREATAERMFLHVLQGHCN 248 Query: 244 VPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 PI YA +GE+ LRA V DG ++ D +G S+A LL GARE+ Sbjct: 249 SPIAGYARTERNGELSLRASVFTLDGKTVLNAHEWAGRLDPATLGTSVAVALLRQGAREL 308 Query: 303 LAEVY 307 + ++ Sbjct: 309 IDDIP 313 >UniRef50_C6XKH7 Porphobilinogen deaminase n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XKH7_HIRBI Length = 323 Score = 333 bits (855), Expect = 5e-90, Method: Composition-based stats. Identities = 110/299 (36%), Positives = 152/299 (50%), Gaps = 7/299 (2%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPG-LVVELVPMVTRGDVILDTPLAKVGGKG 60 +++I R SPLA+ QA + + +E+ T GD +LD L GGKG Sbjct: 17 STQIVKIGARGSPLAVQQAEDFAARFKEIVGNTVEIEIHTFTTSGDQLLDKRLQDAGGKG 76 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF +EL++A L R DI VHS+KDVP P GL + REDPRDA ++ LP Sbjct: 77 LFTRELDIAQLSGRIDIVVHSLKDVPTVLPDGLQMGCYLPREDPRDALFGKVG-NIKDLP 135 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GT+SLRR Q RPDL I RGNV TRL KL+ G+ DA +LA AGL RLG+ Sbjct: 136 HGATLGTASLRRSAQALALRPDLKIVMFRGNVQTRLRKLEEGQADATLLAAAGLNRLGMT 195 Query: 181 SRIRAALPPEISLPAVGQGAVGIE-CRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 + +P E LPA GQG V + + ++ E+ + AERA RL+ Sbjct: 196 DKAAGFMPKEEMLPACGQGIVCTTLTNNAEDWIFKACLQIDVLESRIAAIAERAFLKRLD 255 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRG----APQDAEQMGISLAEEL 294 G C+ PI + + + +R V A DGS+ + A +G L E++ Sbjct: 256 GSCRTPIAGHLSFNETGVDMRGEVLADDGSKRWFSQMSLDTIPDENQAASLGFELGEKV 314 >UniRef50_Q7UPN0 Porphobilinogen deaminase n=1 Tax=Rhodopirellula baltica RepID=HEM3_RHOBA Length = 337 Score = 332 bits (853), Expect = 7e-90, Method: Composition-based stats. Identities = 127/332 (38%), Positives = 182/332 (54%), Gaps = 27/332 (8%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 LRIATR+SPLA+WQA +V L G E+VP+V++GD + P+ GLF Sbjct: 9 TTRLRIATRESPLAMWQAEHVAKLLKKH--GFQTEIVPLVSKGDTDM-RPIDGTRQVGLF 65 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS------- 115 K ++ AL+++ AD+AVHS+KD+P E L + RE DA V + Sbjct: 66 TKRIQQALVDDEADVAVHSLKDLPTEPDSRFVLAAVPPRESVLDALVFADNSPHLESQTG 125 Query: 116 ----LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAV 171 LD LP G+ VGT S RR QL + RPDL + +RGNV TRL+KL+ GE+DAI+LA Sbjct: 126 AESPLDYLPQGARVGTGSTRRLAQLKQLRPDLEVLPIRGNVQTRLAKLNAGEFDAIVLAH 185 Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231 AG+ RL + P + +PA GQGA+GIE R DD+ + +A LN L TAE Sbjct: 186 AGILRLEMTDLPHRLFPLDEMIPAPGQGALGIEVRSDDAGAMDAIANLNDAAARLAATAE 245 Query: 232 RAMNTRLEGGCQVPIGSYAELI----DGEIWLRALVGAPDGSQIIRGERRGA-------- 279 R + + L GGC PI +A+L E+ LRA+V + DG Q ++ + R Sbjct: 246 RKVLSELHGGCLAPIACHAKLETSNHGTELCLRAIVMSADGEQRLQEDARITVQPNDADL 305 Query: 280 -PQDAEQMGISLAEELLNNGAREILAEVYNGD 310 +A ++G +A+ L + GA ++++ V Sbjct: 306 HVAEAHELGTLVAKRLRDKGADKLISTVRENH 337 >UniRef50_O29026 Probable porphobilinogen deaminase n=1 Tax=Archaeoglobus fulgidus RepID=HEM3_ARCFU Length = 289 Score = 332 bits (852), Expect = 1e-89, Method: Composition-based stats. Identities = 111/294 (37%), Positives = 163/294 (55%), Gaps = 11/294 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 L + TR S LAL Q + V ++L + VE+ + T GD++ D PL + G G FV+ Sbjct: 2 KLIVGTRGSKLALAQTNKVAERLKERY---EVEIRIVKTAGDIMKDKPLYEFKGMGAFVR 58 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L+ AL E + D+AVHS KDVP + +G + + ER+ P D +S + +L+ L G++ Sbjct: 59 ALDTALAEGKVDVAVHSFKDVPSQRVEGTVVAAVIERDSPCDVLISRDGSTLEELDEGAV 118 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI- 183 VGTSSLRR+ QL+ R DL +LRGN+ TRL KL G YDAI++A AGLKRLGL+ + Sbjct: 119 VGTSSLRRRAQLSRLRGDLRFENLRGNLDTRLRKLREGNYDAIVVAEAGLKRLGLDREVE 178 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 PPE+ +P QG + I R + +L+A LN +T L ERA+ L GC Sbjct: 179 YQPFPPEVIVPPANQGIIAIATRKGEE---DLVAFLNDEKTWLEAMVERAVIKELGVGCA 235 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 VP+G YAE + L + + +R E + + A + + ++L Sbjct: 236 VPVGVYAEAQS-RVRLICEILD---KKYLRVEEKLSKDTAVEEAAEIGKDLRKE 285 >UniRef50_A4QB59 Porphobilinogen deaminase n=15 Tax=Corynebacterium RepID=HEM3_CORGB Length = 302 Score = 331 bits (850), Expect = 2e-89, Method: Composition-based stats. Identities = 118/304 (38%), Positives = 171/304 (56%), Gaps = 8/304 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 L+I TR S LA QA ++D+L + G EL + T GDV + +P+ ++G G+F + Sbjct: 2 TLKIGTRGSKLATTQAGTIRDQLK--YFGRDAELHIVTTPGDVNM-SPVERIG-VGVFTQ 57 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L L D+AVHSMKD+P LV + R D R+A ++ + +L LP G+ Sbjct: 58 ALRDVLHAGECDVAVHSMKDLPTAADPRFHLV-VPTRADSREALIARDGLTLAELPEGAK 116 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGTS+ RR QL RPDL I LRGN+ TR+ K+ +GE DA++LA AGL R+G++ R Sbjct: 117 VGTSAPRRISQLKAIRPDLEILPLRGNIDTRMGKVTSGELDAVMLAYAGLTRVGMQDRAT 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 +I +PA QGA+ IECR DD+ T L L H +T + AER + RLE GC Sbjct: 177 EVFDADIIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVLNRLEAGCTA 236 Query: 245 PIGSYAELI---DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 P+ ++A L + L A V A DGS + G E++G +A++L++ GA Sbjct: 237 PVAAHATLDGYSGDTMTLTAGVYALDGSDQLVFSAEGDGARPEELGELVAQQLIDAGAAN 296 Query: 302 ILAE 305 +L + Sbjct: 297 LLGD 300 >UniRef50_B2IAW6 Porphobilinogen deaminase n=4 Tax=Alphaproteobacteria RepID=B2IAW6_BEII9 Length = 337 Score = 330 bits (847), Expect = 4e-89, Method: Composition-based stats. Identities = 138/306 (45%), Positives = 179/306 (58%), Gaps = 5/306 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 LR+ TR SPLAL QAH + D+L +H V + + T GD+I D PL+ GGKGLF Sbjct: 19 LRLGTRGSPLALAQAHELADRLARAHGFAKEAVAITIIRTSGDMIQDRPLSLAGGKGLFT 78 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KEL+ AL+E D+AVHS KD+P P+ L + RED RD ++S LP GS Sbjct: 79 KELDQALIEGMVDLAVHSAKDLPTILPEDLIIAGYLPREDVRDVWISPKAGHPRDLPPGS 138 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +VGT+SLRR L RPDL +R LRGNV TRL+KL GE DA +LA+AGL+RLGL + Sbjct: 139 VVGTASLRRGALLKRLRPDLEVRLLRGNVETRLAKLAAGEVDATLLALAGLRRLGLADKA 198 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 L E LPA GQGA+GI R DD+ T LLA + T + + AER T L+G C+ Sbjct: 199 TQVLAIEDFLPAAGQGAIGITTRRDDAATLALLAPILDPATHVALAAERGFLTVLDGSCK 258 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 PIG++A + ++ LR +V PDGS+ G + + A EL AR IL Sbjct: 259 TPIGAHATVEHDQVTLRGIVLRPDGSEWFEACESGPLESGS---LEAARELGETAARAIL 315 Query: 304 AEVYNG 309 A + G Sbjct: 316 ARLPEG 321 >UniRef50_Q46CH0 Probable porphobilinogen deaminase n=7 Tax=Euryarchaeota RepID=HEM3_METBF Length = 316 Score = 330 bits (847), Expect = 4e-89, Method: Composition-based stats. Identities = 113/304 (37%), Positives = 163/304 (53%), Gaps = 7/304 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG-GKGLFVK 64 + I TR S LAL QA V L A G+ L + T GD D PL V G G FV+ Sbjct: 1 MIIGTRGSQLALAQAETVARLLKAK--GVETSLKIIKTSGDRFTDRPLHAVSSGVGAFVR 58 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 EL+ +LE + DIAVHSMKD+P P L V + +R+ P D ++ + LD L SI Sbjct: 59 ELDEVMLEGKIDIAVHSMKDMPTIRPPTLPTVAVLKRDTPFDLLLTYDGTPLDELSEQSI 118 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSSLRR Q+ RPDL+ + LRGN+ TRL KL G+YD I+LA AGL+R+G E Sbjct: 119 IGTSSLRRAAQIKRYRPDLVTQDLRGNIDTRLRKLKEGKYDGILLAKAGLERMGWELE-G 177 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L P+ P+ QG + + R + + ++ L+H ++ + ER + + L GGC Sbjct: 178 EILSPDFFCPSPNQGTIAVVTRAE-TEAEAAVSRLDHTDSRIATEIERILISELGGGCTT 236 Query: 245 PIGSYAELIDGE--IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 PIGSYAE++ + +RA V + DG + + + L L++ G +++ Sbjct: 237 PIGSYAEIMPDRKKLHVRAEVLSLDGEETVGINEFIPMAGGIEKARELGSSLVHMGGKKL 296 Query: 303 LAEV 306 E Sbjct: 297 ADEA 300 >UniRef50_B6W7F3 Putative uncharacterized protein n=1 Tax=Anaerococcus hydrogenalis DSM 7454 RepID=B6W7F3_9FIRM Length = 318 Score = 330 bits (846), Expect = 5e-89, Method: Composition-based stats. Identities = 103/309 (33%), Positives = 155/309 (50%), Gaps = 12/309 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 ++I +R S LAL QA+ VKD L GL ++V + T+GD I D + ++ KG+FV+E Sbjct: 2 IKIGSRASKLALIQANMVKDILEKE--GLEAQIVEISTKGDRIRDRKIDQLNSKGVFVRE 59 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALPAGSI 124 +E LL+ DIAVHS+KD+P + L + EDPRD FV + + +D L ++ Sbjct: 60 IEEKLLDKTIDIAVHSLKDMPSQIDDRLIFTPPLKGEDPRDCFVGKDVFKKMDDL-NNAL 118 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGT S RR CQ ++ +++RGNV TR+ K+ + D +ILA +GL R GL+ I Sbjct: 119 VGTGSNRRVCQGKNHFSNIKFKAIRGNVETRIKKVQSENLDGVILAKSGLIRAGLDGEIN 178 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L P I P+ QG +GIE R +D + E+ + +T R+ ERA L C Sbjct: 179 FDLDPHIFTPSPCQGILGIEIRKEDKKLFEIFKKNSDEKTLFRMETERAFQKELGADCST 238 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 P+G + E+ +I L + +I G + + LA L Sbjct: 239 PMGIFTEIDHDKITLTGSMAFDKDDRINYERVSGNISERIHLAQKLARTLKKK------- 291 Query: 305 EVYNGDAPA 313 Y + P Sbjct: 292 -SYKKNNPC 299 >UniRef50_C4QMG7 Hydroxymethylbilane synthase (Porphobilinogen deaminase, putative) n=1 Tax=Schistosoma mansoni RepID=C4QMG7_SCHMA Length = 411 Score = 328 bits (843), Expect = 1e-88, Method: Composition-based stats. Identities = 118/302 (39%), Positives = 161/302 (53%), Gaps = 25/302 (8%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 NV+R+ +R+S LAL Q + L +P ++ E+V M T GD ILD L+K+G K LF Sbjct: 8 NVVRVGSRRSNLALLQTGMAVNLLQKQNPHILFEVVEMATVGDKILDVSLSKIGDKSLFT 67 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALP 120 KELE ALL D+ VHS+KDVP P GL L + R P D + L LP Sbjct: 68 KELENALLSGEVDLVVHSLKDVPSTLPSGLVLGCVFARVSPEDVVLMAPHYRGRKLSDLP 127 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--------------NGEYDA 166 GS VGTS++RR L + P L S+RGN+ TRL+KLD + YDA Sbjct: 128 IGSTVGTSAVRRVATLTRKYPHLKFVSIRGNLNTRLAKLDTPPASKDNCCSGNPSPSYDA 187 Query: 167 IILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETAL 226 IILA AG++R+G RI L S AV QGA+ ECRL D+ +LL+ ++ AL Sbjct: 188 IILAKAGVERMGWSHRIDQVL--TDSFYAVSQGALACECRLVDNFIMDLLSHIHDESAAL 245 Query: 227 RVTAERAMNTRLEGGCQVPIGSYAE--LIDG----EIWLRALVGAPDGSQIIRGERRGAP 280 AER++ +L+GGC +PIG ++ L ++ L A + + DG + I Sbjct: 246 TTIAERSLMRQLDGGCSIPIGVRSDLVLKGDLNYYQLTLHANILSVDGGKSIERSASVVF 305 Query: 281 QD 282 D Sbjct: 306 PD 307 >UniRef50_C2FZW8 Porphobilinogen deaminase n=2 Tax=Sphingobacterium spiritivorum RepID=C2FZW8_9SPHI Length = 528 Score = 328 bits (842), Expect = 1e-88, Method: Composition-based stats. Identities = 112/311 (36%), Positives = 158/311 (50%), Gaps = 24/311 (7%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 ++ L I TR S LA+WQA+++KD+L A+ G+ EL + T+GD+I L K+ GKG Sbjct: 1 MNRKLIIGTRGSQLAMWQANHIKDRLAAA--GIDSELKVIKTQGDIIQHLRLDKLEGKGF 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY----DSLD 117 F KELE LL + D+AVHS KD+P P GL + + ERE P + + Sbjct: 59 FTKELEEELLSSTIDLAVHSHKDLPTVNPPGLIIAAVSERESPAELLIVLKDCVDIKKRL 118 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKR- 176 +L + VGTSS RR+ QL RPDL LRGN+ TR+ KL + YDAIILA AG++R Sbjct: 119 SLKHNATVGTSSNRRKAQLLSLRPDLEFDDLRGNLQTRIQKLRDENYDAIILAKAGVERI 178 Query: 177 -LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235 + L +PP +PA QG + I+ R D E L +++ E A + ER + Sbjct: 179 DMDLSDFYVEEIPPVELIPAPAQGVLAIQIRESDQELFEALQVIHNKEVAEVIAVERKVL 238 Query: 236 TRLEGGCQVPIGSYAELIDGEIWLRALVGA-----PDGSQIIRGERRGAPQDAEQMGISL 290 + GC P+G Y +G+ V PD I R G + Sbjct: 239 NLFDAGCHAPLGCYCRKSEGKYEAWTSVAETSDEFPDRLYIQRDSTEG-----------M 287 Query: 291 AEELLNNGARE 301 AEE+ A++ Sbjct: 288 AEEIFTKFAKD 298 >UniRef50_A0DD68 Chromosome undetermined scaffold_46, whole genome shotgun sequence n=2 Tax=Paramecium tetraurelia RepID=A0DD68_PARTE Length = 306 Score = 328 bits (842), Expect = 2e-88, Method: Composition-based stats. Identities = 124/313 (39%), Positives = 171/313 (54%), Gaps = 13/313 (4%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTR-GDVILDTPLAKVGGKG 60 + LRIATR S LA+ Q +YV +L E++ + GDV L PL ++ G Sbjct: 1 MQRQLRIATRSSALAMAQTNYVISELKQ-----ECEIIKVSNEVGDVNLQDPLYQMPTVG 55 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLD 117 +F K++E LLE +AD+AVHS+KD+P L L + E D + N Y SL Sbjct: 56 VFTKQVEQYLLEQKADVAVHSLKDLPTIIDAQLHLAAYTKFEQRGDVVLLNKKYNYKSLS 115 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177 LP G VGTSSLRR + R P L + ++RGN+ TR+ KLD G+YDAIILA AG+ RL Sbjct: 116 ELPDGLKVGTSSLRRIATIRSRYPKLNLINIRGNLNTRIQKLDEGQYDAIILAKAGILRL 175 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 GL +I L + L A Q A+GI+CR DD T L LN + R AER Sbjct: 176 GLAEKISFDLDEKEFLYAPAQAALGIQCRKDDLETIGRLQILNDTDAQKRCVAERMFLNL 235 Query: 238 LEGGCQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 LEGGC++PI Y+E DG+++++ V A DGS++I E E +G L E++ Sbjct: 236 LEGGCRLPIAVYSECREDGQVYIKGRVLAVDGSKVIEDEA---LDHFEIVGQILCEKIKV 292 Query: 297 NGAREILAEVYNG 309 G E++ + Sbjct: 293 LGGVELIESLKQQ 305 >UniRef50_Q4T5L1 Chromosome undetermined SCAF9206, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4T5L1_TETNG Length = 385 Score = 328 bits (842), Expect = 2e-88, Method: Composition-based stats. Identities = 132/383 (34%), Positives = 188/383 (49%), Gaps = 85/383 (22%) Query: 13 SPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLE 72 S LA Q V +KL +P + +E+V M T GD ILDT L+K+G K LF KELE AL Sbjct: 1 SQLARIQTDSVAEKLKELYPDVHLEIVAMSTTGDKILDTALSKIGEKSLFTKELENALER 60 Query: 73 NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALPAGSIVGTSS 129 N D+ VHS+KD+P P G + + +RE+P DA V + +LDALPA S++GTSS Sbjct: 61 NEVDLVVHSLKDLPTSLPPGFTIGAVLKRENPHDAVVLHPKNAGKTLDALPAHSVIGTSS 120 Query: 130 LRRQCQLAERRPDLIIRSL------------------------RGNVGTRLSKLDN-GEY 164 LRR QL +R P L + + RGN+ TRL KLD ++ Sbjct: 121 LRRAAQLKKRFPHLDFKDIVSSERCFLPVQPGHRCFFLSSRSQRGNLNTRLKKLDEKEDF 180 Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224 AIILA AGL+R+G ++RI L PE + AVGQGA+ +E R D+ E+++ L+ +T Sbjct: 181 AAIILAAAGLRRMGWDNRISQILEPEDCMYAVGQGALAVEVRAKDADILEMVSVLHDPDT 240 Query: 225 ALRVTAERAMNTRL----------------------------EGGCQVPIGSYAELIDGE 256 LR AERA L EGGC VP+ + ++ D + Sbjct: 241 VLRCIAERAFLKHLVQHTHTHTHTHTHTRSLAVAHWNLFCLQEGGCSVPVAVHTKVKDSQ 300 Query: 257 IWLRALVGAPDGSQIIRGERRGAP-----------------------------QDAEQMG 287 ++L V + DGS ++ + + AE++G Sbjct: 301 LYLTGAVYSLDGSDSLKETMQTSVAAPADGSPDEVDECARVGVTANKIPGEAQDRAERLG 360 Query: 288 ISLAEELLNNGAREILAEVYNGD 310 + LA+ LL+ GA+EIL + Sbjct: 361 VDLAKLLLSKGAKEILTVARQLN 383 >UniRef50_D2RH82 Porphobilinogen deaminase n=2 Tax=Archaeoglobaceae RepID=D2RH82_ARCPR Length = 292 Score = 328 bits (841), Expect = 2e-88, Method: Composition-based stats. Identities = 107/296 (36%), Positives = 161/296 (54%), Gaps = 9/296 (3%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + + + TR S LAL Q V ++L G VE+ + + GD++ D PL + G G Sbjct: 1 MSERVVVGTRGSKLALAQTSKVVERLKEE--GYSVEIRIIKSTGDIMKDKPLYEFKGSGA 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FV+ LE AL+ D+AVHS KD+P +G+ + + ER+ P DAF++ N +SL+ + Sbjct: 59 FVRALEHALVRGEIDVAVHSYKDIPSNMLEGVTVSAVLERDSPYDAFIARNGESLEEIKP 118 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 +++GTSSLRR+ QL R DL +LRGNV TRL KL G YDAI+LA AG++RLGL Sbjct: 119 NAVIGTSSLRRRAQLKLYRSDLRFENLRGNVDTRLRKLREGLYDAIVLAEAGIQRLGLNV 178 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + LP E +P QG + ++ R+ + +L+ +NH ET + ER + L G Sbjct: 179 KY-QRLPIERFVPPANQGIIAVQTRVGEE---DLVKFMNHEETWIEAEVERIVMKTLGVG 234 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 C +P G YAE ++ L V DG + + + + A + +AE Sbjct: 235 CAIPAGIYAECRG-KVRLIVQVIR-DGRE-FKVIEELSRESAIEEAREIAENFREE 287 >UniRef50_D1BFI8 Hydroxymethylbilane synthase n=4 Tax=Actinomycetales RepID=D1BFI8_SANKS Length = 312 Score = 327 bits (840), Expect = 2e-88, Method: Composition-based stats. Identities = 126/309 (40%), Positives = 173/309 (55%), Gaps = 14/309 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LRI TR S LAL Q V D L G VE+VP+ T GD +L L+++GG G+FV Sbjct: 7 LRIGTRSSLLALTQTGTVADDLRRL-TGRPVEIVPVTTDGD-VLTGSLSQMGGTGVFVTA 64 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L ALL++R D+AVHS+KD+P GL V R+DPRDA S L LP G+ V Sbjct: 65 LRAALLDDRCDVAVHSLKDLPTAGVLGLQHV-TPVRQDPRDALCSRAGHRLADLPHGARV 123 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--DNGEYDAIILAVAGLKRLGLESRI 183 GT S RR QL RPDL + +RGN+ TRL ++ + G+ DA++LA AGL R+G E I Sbjct: 124 GTGSPRRAAQLRLVRPDLDVVDIRGNIDTRLGRVHPETGDLDAVVLAAAGLNRIGREHAI 183 Query: 184 RAALPPEISLPAVGQGAVGIECR----LDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 + PA GQGA+ +E R +D L+ T+L V AERA+ RLE Sbjct: 184 TELISVTDMAPAPGQGALAVETRSSLLEEDPVVARAFDQLDDPATSLSVLAERALLARLE 243 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-----GAPQDAEQMGISLAEEL 294 GC P+G++A + DG + L A+V PDGS+ +R + + +A +G ++A+ Sbjct: 244 AGCAAPVGTHATVSDGLLTLHAVVARPDGSEQLRHNQSTEVADTSTAEAVALGEAVADHF 303 Query: 295 LNNGAREIL 303 L GA + Sbjct: 304 LALGAASFI 312 >UniRef50_C5RMN3 Porphobilinogen deaminase n=1 Tax=Clostridium cellulovorans 743B RepID=C5RMN3_CLOCL Length = 300 Score = 327 bits (840), Expect = 3e-88, Method: Composition-based stats. Identities = 113/301 (37%), Positives = 168/301 (55%), Gaps = 8/301 (2%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + ++RI TR+S LAL Q + V D + HP + E+V M T+GD ILD L GGKG Sbjct: 1 MKKIIRIGTRKSKLALMQTNIVIDAIKKKHPEINCEVVEMSTKGDEILDKSLLSFGGKGA 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS-NNYDSLDALP 120 FV E E A+ D+AVHS KD+P++ GL +V + +REDPRD V+ NN D+++ Sbjct: 61 FVSEFEKAIKSGEIDLAVHSAKDMPMDLLTGLKIVAVTKREDPRDVLVTANNKDTINDFN 120 Query: 121 A-GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 ++GT+SLRR+ Q+ ++ + LRGNV RL KL +GEYD IILA AGLKRLGL Sbjct: 121 KTNKLIGTTSLRRKLQIKRLLNNVDTKDLRGNVQRRLEKLISGEYDGIILAAAGLKRLGL 180 Query: 180 ESRIR---AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236 R L E +PA GQG + +E R + L ++++ E + ER + Sbjct: 181 LDDERINLNYLSVEDFIPAGGQGIIAVEGRAE-EEFSFLKDSIHNEEAMYSLEVERYVMK 239 Query: 237 RLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 +L GC PIG+Y+ + I+L + ++ R + + ++ ++ L EE+L Sbjct: 240 KLNAGCNEPIGAYSFIDKDTIFLD--IIYEHNGKVSRKKGSDSIENRLKLTEKLVEEILQ 297 Query: 297 N 297 Sbjct: 298 E 298 >UniRef50_B3RTQ8 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RTQ8_TRIAD Length = 314 Score = 327 bits (839), Expect = 3e-88, Method: Composition-based stats. Identities = 120/338 (35%), Positives = 172/338 (50%), Gaps = 64/338 (18%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M + V+RI TR+S LA+ Q H V D L HP +E+V M T GD +LD L ++G Sbjct: 4 MEETVVRIGTRKSQLAMIQTHSVVDALREIHPKARIEIVTMDTIGDRVLDKALPEIGQTN 63 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF K+LEVAL +N+ D+ +HS+KDVP P+GL + I Sbjct: 64 LFTKDLEVALTDNKIDLIIHSLKDVPSTLPEGLAIAAI---------------------- 101 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGL 179 G+++GTSSLRR QL R P L ++RGN+ TRL KLD G YDA++LA AG++ Sbjct: 102 -GNVIGTSSLRRIAQLKRRFPHLKFENVRGNLNTRLKKLDESGIYDALVLAGAGVE---- 156 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 L P+ L A+GQGA+GIE R +D +T L++A ++ + AERA L+ Sbjct: 157 -------LTPDECLYAIGQGALGIEIRKNDKKTFSLISAYTDFDSLVCNAAERAFLRFLD 209 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ------------------ 281 GC VPIG Y E + ++ + V + DGS+ ++ Sbjct: 210 KGCSVPIGVYTEFTENKLKITGAVFSLDGSKRVQYSDECTISGLNAKDDCESNYESLSSI 269 Query: 282 -----------DAEQMGISLAEELLNNGAREILAEVYN 308 +AE++G +AE +L N E+LAE Sbjct: 270 LCPSEMCNSLIEAERLGKYVAEMILKNHGGEVLAEARQ 307 >UniRef50_C6XST0 Porphobilinogen deaminase n=2 Tax=Pedobacter RepID=C6XST0_PEDHD Length = 526 Score = 327 bits (838), Expect = 4e-88, Method: Composition-based stats. Identities = 115/272 (42%), Positives = 157/272 (57%), Gaps = 8/272 (2%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L I TR S LALWQA+++KDKL A G+ EL + T+GD IL+ L K+ GKG F Sbjct: 2 KRLIIGTRGSDLALWQANFIKDKLAAI--GVEAELKIIKTQGDKILNLRLDKLEGKGFFT 59 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAF-VSNNYDSLD---AL 119 KELE LL DIAVHS KD+P P GL + + EREDP + + + S++ +L Sbjct: 60 KELEEELLGGTIDIAVHSHKDLPTVHPAGLTIAAVTEREDPSELLLILKDCVSINHKLSL 119 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG- 178 G++VGTSS RR+ QL RPDL I LRGNV TR+ KL + +YDAI+LA AG+ RL Sbjct: 120 KKGAMVGTSSNRRKAQLLALRPDLNIEDLRGNVPTRIQKLRDEDYDAILLARAGVNRLNI 179 Query: 179 -LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 L + +PA QGA+ I+ R +++ ++L +NH ETA + ER + Sbjct: 180 DLSEFHVEVVDTTELVPAPAQGALAIQIRENENELFDILQQINHSETAEEIAIERKVLNL 239 Query: 238 LEGGCQVPIGSYAELIDGEIWLRALVGAPDGS 269 EGGC +P+G Y + DG+ + D Sbjct: 240 FEGGCHMPLGCYCKKEDGQYEVWTSKAETDED 271 >UniRef50_Q47LA7 Porphobilinogen deaminase n=3 Tax=Actinomycetales RepID=HEM3_THEFY Length = 320 Score = 326 bits (836), Expect = 7e-88, Method: Composition-based stats. Identities = 127/322 (39%), Positives = 178/322 (55%), Gaps = 11/322 (3%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M R+ TR+S +A Q+ V + L A G+ VELV + + GD I L ++GG G Sbjct: 1 MSTTPARLGTRRSTMATNQSRRVAEILTAR-TGVPVELVLITSFGD-ITRAHLTQLGGTG 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 +FV L ALL + AVHS+KD+P +G+ L + ER+DPRDA + + LP Sbjct: 59 VFVSALRDALLAGEVEFAVHSLKDLPTAPTEGIVLAAVTERDDPRDALCARDGLKFADLP 118 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGT S RR QLA RPDL +RGN TRL K+ +GE DA++LA AGL R+G Sbjct: 119 PGATVGTGSPRRVAQLAALRPDLRYVPIRGNAETRLGKVASGELDAVVLAYAGLHRVGRL 178 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDD-SRTRELLAALNHHETALRVTAERAMNTRLE 239 + + LPA GQGA+ +ECR D + L A++H T VTAER + LE Sbjct: 179 DDVTDVFDVDQVLPAPGQGALAVECRTADFTGPLRYLTAVDHLPTRAAVTAERVILAELE 238 Query: 240 GGCQVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQD-------AEQMGISLA 291 GC P+G+YAE + + + LRA V A DGSQ +R E+ + A +G LA Sbjct: 239 AGCAAPVGAYAEFVAEDRLRLRAAVVATDGSQAVRAEQTVTVTEFPDAVQAATALGRQLA 298 Query: 292 EELLNNGAREILAEVYNGDAPA 313 +++ GA +I+A+ G + Sbjct: 299 HDMIEQGADQIVADAAAGRGES 320 >UniRef50_A3MLK5 Porphobilinogen deaminase n=155 Tax=Proteobacteria RepID=HEM3_BURM7 Length = 329 Score = 326 bits (836), Expect = 7e-88, Method: Composition-based stats. Identities = 161/312 (51%), Positives = 207/312 (66%), Gaps = 3/312 (0%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 L IA+R+S LA+WQA +V+D L +P V+++ M TRGD ILD L+KVGGKGLFVK Sbjct: 13 TLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVK 72 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 ELE AL + RAD+AVHS+KDVP+ P+G L + REDPRDAFVSN+Y SLDALPAG++ Sbjct: 73 ELESALADGRADLAVHSLKDVPMALPEGFALAAVMSREDPRDAFVSNDYASLDALPAGAV 132 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGTSSLRR+ L R P L +R LRGN+ TRL+KLD G+Y AIILA AGLKRLGL +RIR Sbjct: 133 VGTSSLRREAMLRARHPRLDVRPLRGNLDTRLAKLDRGDYAAIILAAAGLKRLGLAARIR 192 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 A L + SLPA GQGA+GIE + LA L+ H +AL V AERA++ L G C+V Sbjct: 193 ALLDVDDSLPAAGQGALGIEIAARRADVAAWLAPLHDHASALAVEAERAVSRALGGSCEV 252 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQI---IRGERRGAPQDAEQMGISLAEELLNNGARE 301 P+ ++A GE+ L V DG+++ R DA +G +++ L GAR Sbjct: 253 PLAAHAVWRGGELHLTGSVSTTDGARVLAAHAHARAATAADALALGRRVSDALERQGARA 312 Query: 302 ILAEVYNGDAPA 313 I+ + A A Sbjct: 313 IVDALVAASAQA 324 >UniRef50_UPI000174444E Hydroxymethylbilane synthase n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI000174444E Length = 318 Score = 325 bits (835), Expect = 9e-88, Method: Composition-based stats. Identities = 119/307 (38%), Positives = 156/307 (50%), Gaps = 18/307 (5%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG----- 57 + LR+ TR S LAL QA V+ L A+HP L VE + T GD D ++ Sbjct: 6 TDTLRLGTRGSELALRQAEMVEAALHAAHPYLRVERKVIATTGDKRPDLRFSEFTEGDRL 65 Query: 58 GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD 117 KG+F KELE+AL DIAVHS+KDVP + + + R D +S +L Sbjct: 66 DKGIFTKELEIALASGEIDIAVHSLKDVPTVLDEKFFIAGVLPRAPIEDVLISREGYTLA 125 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG-EYDAIILAVAGLKR 176 LPAG+ VGTSS+RR QL P + +RGNV TR+ KL + DAI+LA AGL+R Sbjct: 126 TLPAGAKVGTSSVRRIRQLQWLNPGVECVEIRGNVPTRIRKLFAPSDLDAILLARAGLER 185 Query: 177 LGLES----------RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETAL 226 L L L E LPA GQGA+GIE R+DD+ T E L A+NH ET Sbjct: 186 LSLLDGEHVVVDGQPLHAVILDCEEFLPAAGQGAIGIEARVDDAHTLEFLKAINHEETYA 245 Query: 227 RVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPD--GSQIIRGERRGAPQDAE 284 RVTAER L+ GCQ PIG++ L +G + ++ V G + Sbjct: 246 RVTAEREFLHILKAGCQTPIGAHTFLENGVLQMKVRVFDETDPGRPPKEVTSTEPYHSPK 305 Query: 285 QMGISLA 291 + +A Sbjct: 306 GLAAEVA 312 >UniRef50_A8AAB4 Probable porphobilinogen deaminase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=HEM3_IGNH4 Length = 304 Score = 325 bits (835), Expect = 9e-88, Method: Composition-based stats. Identities = 113/295 (38%), Positives = 157/295 (53%), Gaps = 7/295 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILD--TPLAKVGGKGLF 62 ++IA R S L+L Q L+ P L E++ + T GD LAK G GLF Sbjct: 2 KIKIAARGSKLSLKQVSMFTSYLLKFFPDLEYEVITVKTTGDKANAPFEELAKRGLTGLF 61 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALPA 121 KE+ A+LE +AD+AVHS+KD+P E L + R+ P D +S + LP Sbjct: 62 EKEVNKAVLEGKADVAVHSLKDLPTELDPRLEIAAFLPRDPPYDVLISRAGNYDIFDLPK 121 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 GS+VGTSS RR+ + RPDL+++ LRGNV TRL KL GEYDAI+LA AG+ RLGL Sbjct: 122 GSVVGTSSARRKALIKNLRPDLVVKDLRGNVDTRLEKLRRGEYDAIVLAEAGVSRLGLNV 181 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 L + P+ GQG + R S +LL +++ ++ TAER + GG Sbjct: 182 DYVR-LDWRLFPPSPGQGIIVAVTRKG-SEISDLLKSISDVKSEKLATAERTVLKEFGGG 239 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 C V +G+ A I LRA V +P G + + E G + E++G+ AE L Sbjct: 240 CFVALGAIAFEEGSLIRLRATVLSPSGRERVDVELIG--KGPEEVGMRAAERLKA 292 >UniRef50_A4CHM3 Porphobilinogen deaminase n=4 Tax=Bacteroidetes RepID=A4CHM3_9FLAO Length = 315 Score = 325 bits (835), Expect = 1e-87, Method: Composition-based stats. Identities = 121/318 (38%), Positives = 167/318 (52%), Gaps = 18/318 (5%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + LRI TR S LALWQA V+D+L A+ G ELVP+ + GD++LD PL ++G G+ Sbjct: 1 MSRALRIGTRDSELALWQAQTVRDRLEAA--GHRAELVPVKSTGDLVLDKPLYELGITGI 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F K L+VALL D+AVHSMKDVP P+G+ + ER RD V + P Sbjct: 59 FTKTLDVALLREDIDLAVHSMKDVPTALPEGICQAAVLERASARDVLV-HKGLGFLDGP- 116 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 + T SLRR+ Q R P + LRGNV TRL L +D I A AGL+R+GL Sbjct: 117 -GTIATGSLRRKAQWLNRYPAHQVTGLRGNVNTRLKLLRENSWDGAIFAQAGLERIGLLP 175 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 L + LPA QGA+ + R D+ RE L+H ++AL V ER LEGG Sbjct: 176 DNAEPL--DWMLPAPAQGAMLVVARTSDTAAREAARPLHHEQSALEVAVEREFLRTLEGG 233 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER-RGAPQ----------DAEQMGISL 290 C PIG+ DG++ L + + DG + R R G+ + DA + G + Sbjct: 234 CSAPIGARVHAADGQLHLEGGLFSLDGKKAFRVTRHTGSLEAGGTGDARFQDAGEFGAAC 293 Query: 291 AEELLNNGAREILAEVYN 308 A E+L++G ++ + Sbjct: 294 AREILDSGGAVLMESIRK 311 >UniRef50_C1TM53 Porphobilinogen deaminase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TM53_9BACT Length = 454 Score = 324 bits (832), Expect = 2e-87, Method: Composition-based stats. Identities = 124/289 (42%), Positives = 159/289 (55%), Gaps = 8/289 (2%) Query: 10 TRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVA 69 +R+S LA Q L GL VE+ M T GD D L+ GG G FVK LE A Sbjct: 160 SRKSALARAQTMEAARALAKK--GLPVEIKTMSTCGDEKQDCHLSAFGGNGAFVKCLEEA 217 Query: 70 LLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSS 129 ++E + D A+HS+KDVP P GL LV + R D VSN+ L+ LPAG++VGTSS Sbjct: 218 IMEGKGDGAIHSLKDVPSVLPDGLELVAVLPRASTSDVIVSNHKGGLEGLPAGAVVGTSS 277 Query: 130 LRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPP 189 LRR+ QLA RPDL +RGNV TRL+KL +G+ DAI+LA AGL RLG+ LP Sbjct: 278 LRRKAQLAITRPDLDYTLIRGNVNTRLAKLQSGDADAIVLAKAGLDRLGISPEGATTLP- 336 Query: 190 EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSY 249 LPA QG + +E R SR E A+NH T L AER + L+ GC VP + Sbjct: 337 --FLPAPCQGIIAVEARSG-SRLAEEFRAINHRPTWLMALAERELLESLQVGCHVPFAAL 393 Query: 250 AELIDGEIWLRALVGAPDGSQI-IRGERRG-APQDAEQMGISLAEELLN 296 +E + GE+ LRA + DG I G + DA +G +A + Sbjct: 394 SEWVGGELRLRAQTLSYDGRHIDFEGSLAVRSDDDARDLGRDVALSIKA 442 >UniRef50_C9M5W1 Hydroxymethylbilane synthase n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M5W1_9BACT Length = 714 Score = 323 bits (829), Expect = 4e-87, Method: Composition-based stats. Identities = 115/295 (38%), Positives = 160/295 (54%), Gaps = 7/295 (2%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 LR+A+R+S LA+ Q+ V ++L + G VE++P TRGD + D L GGKGLFV Sbjct: 424 RPLRLASRESELAMAQSRLVAERLHEA-TGFDVEIIPFRTRGDAVADRRLESAGGKGLFV 482 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE A+L +AD+AVHS+KD+P P GL + +R+ D V + + Sbjct: 483 KELERAILSGQADLAVHSLKDMPSSCPDGLAFAALMDRQTAFDCLVLRPGLTGRPV---- 538 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +GTSS RR Q D LRGN+ TRLSKLD GE+DA+ILA AGL+RLGL+ R+ Sbjct: 539 RIGTSSARRIAQGRALFSDAQFVPLRGNLRTRLSKLDGGEFDALILAEAGLRRLGLQERV 598 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + +P+ GQG + ++C D +L++ L+ AERA RL GGC Sbjct: 599 SRVFSADQMIPSAGQGTLAVQCPFDGP-VFDLVSQLDEPAVRTCCLAERAFIDRLNGGCT 657 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 P G+YA + I + L PDG + G+ G D + LA+ L G Sbjct: 658 APHGAYARVDGETIEMIGLYVRPDGKT-LSGKISGPAADGPSLAAELADRLKRRG 711 >UniRef50_C0BZ93 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM 15053 RepID=C0BZ93_9CLOT Length = 298 Score = 323 bits (829), Expect = 4e-87, Method: Composition-based stats. Identities = 118/296 (39%), Positives = 161/296 (54%), Gaps = 5/296 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + +++RI +R+S LA+ QA VK + + P + E+V M T GD ILD L GGKGL Sbjct: 1 MQSIIRIGSRESRLAVKQAEIVKQAVERNCPDIKAEIVTMKTEGDKILDRRLELAGGKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKELE ALL+ R DI VHS+KDVP+E P+ L +V EREDPRD + + ++P Sbjct: 61 FVKELEKALLDGRIDICVHSLKDVPMEVPEDLPVVAFGEREDPRDVLIYKPGRT--SIPE 118 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G ++GTSS RR+ QL P RS+RGNV TRL KL +D +LA AGLKRL +E Sbjct: 119 GGVIGTSSRRRELQLKRLYPSCTFRSIRGNVQTRLRKLSEEGFDGTVLAAAGLKRLHMEE 178 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + +PAVGQG + ++ R L + ++ AER L GG Sbjct: 179 VAGRVFSVDEIIPAVGQGILAVQGRKGRDY--SWLTSFACGKSRAEAEAEREFAAALGGG 236 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 C P+ ++A+ E+ L L G R G A Q+G +LAEE+ Sbjct: 237 CTSPVAAHAQAQGAELKLTGLYYC-GGDIYRTRTRTGETDRARQLGAALAEEMRRE 291 >UniRef50_C2GGB5 Porphobilinogen deaminase n=2 Tax=Corynebacterium glucuronolyticum RepID=C2GGB5_9CORY Length = 290 Score = 323 bits (828), Expect = 6e-87, Method: Composition-based stats. Identities = 121/300 (40%), Positives = 165/300 (55%), Gaps = 11/300 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR S LA QA +V+D L+ + G EL + T GD L +P+ K+G G+F + Sbjct: 2 TLRIGTRGSKLATTQAGHVRDALIRA--GYDAELTIITTPGDKNL-SPVQKIG-VGVFTQ 57 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L A+ + DIAVHS KD+P P+GL + RE P +A ++ + +LD LP G+ Sbjct: 58 ALREAMDRDEIDIAVHSCKDLPTGQPEGLATI-YPVRETPCEALIARDGLTLDQLPEGAK 116 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGT + RR QL RPDL IR LRGNV TR+ K+ +GE DA+ILA AGL R+G Sbjct: 117 VGTGAPRRISQLKALRPDLDIRPLRGNVDTRMGKVTSGELDAVILAHAGLTRIGRGDEAT 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 P +PA QG + +E R L ++ H T L AERA+ + L+ GC Sbjct: 177 QVFDPTYLMPAPAQGILAVESRTHVDAISTL---IDDHAT-LSAQAERAVLSTLQAGCTA 232 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 P+ +Y+ + EI L A A DGS+ I G D +G S+AE+L GA EI+ Sbjct: 233 PLAAYSTVSGDEITLTAGAFALDGSKQIVETATGT--DPVALGTSVAEKLRACGAEEIIR 290 >UniRef50_D2NS36 Porphobilinogen deaminase n=2 Tax=Micrococcaceae RepID=D2NS36_9MICC Length = 454 Score = 323 bits (828), Expect = 7e-87, Method: Composition-based stats. Identities = 135/372 (36%), Positives = 187/372 (50%), Gaps = 71/372 (19%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPG------------LVVELVPMVTRGDVI 48 M + + TR S LAL Q+ + + + + + L + T GD + Sbjct: 78 MSHHEYILGTRGSALALTQSRIAAETVTSLYTEHQAHHGAADAEVVDFTLRTVKTEGD-V 136 Query: 49 LDTPLAKVGGKGLFVKELEVALLEN-------RADIAVHSMKDVPVEFPQGLGLVTICER 101 L PLA +GG G+F L LL+ R D+AVHS+KD+P GL + +R Sbjct: 137 LTGPLATLGGTGVFAAALRQRLLDGENASEENRVDMAVHSLKDLPSAPCPGLVIAATLKR 196 Query: 102 EDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-- 159 EDPRDA V+ + +LD LP GS VGT S RR QL RPDL I +RGNVGTR+ ++ Sbjct: 197 EDPRDALVARDGLTLDTLPEGSRVGTGSPRRAAQLRALRPDLEIVDIRGNVGTRIGRVKG 256 Query: 160 ----------------------------DNGEYDAIILAVAGLKRLGLESRIRAALPPEI 191 +G+ DA++LAV+GLKRLG E I L P Sbjct: 257 LEEHAGKQVVLRQNTETSERADHGVGTERSGDCDAVVLAVSGLKRLGKEELITEYLDPTR 316 Query: 192 SLPAVGQGAVGIECRLD-----------DSRTRELLAAL-------NHHETALRVTAERA 233 LPA GQGA+ +E R D + AL NHHET L V+AERA Sbjct: 317 MLPAPGQGALALEVRESEFENPDPAVLADPEVARPVRALGRALLAANHHETRLAVSAERA 376 Query: 234 MNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---AEQMGISL 290 + RLE GC PIG+YA +++G++ L +V +PDG+ ++R A D AE++G+ + Sbjct: 377 LLRRLEAGCAAPIGAYAHVVEGDLVLSVVVASPDGTDMLRHTSATAELDVPGAERLGVRV 436 Query: 291 AEELLNNGAREI 302 AE+LL GA + Sbjct: 437 AEDLLQMGAAAL 448 >UniRef50_A4WN24 Probable porphobilinogen deaminase n=3 Tax=Thermoproteaceae RepID=HEM3_PYRAR Length = 297 Score = 322 bits (827), Expect = 8e-87, Method: Composition-based stats. Identities = 110/293 (37%), Positives = 157/293 (53%), Gaps = 6/293 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L +ATR S L++ Q + ++ A P + E+ + T GD + D PL ++G KG+F KE Sbjct: 3 LVVATRGSKLSMLQTEELLAQIKAVEPSIEFEIKIVKTTGDEVQDKPLYQIGVKGIFEKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 + +A+L AD+AVHS+KD+P E GL L +R P DA VS L+ LP G++V Sbjct: 63 VNLAVLRGEADVAVHSLKDLPSELSPGLVLAGFSKRAPPFDAVVSTAGYVLETLPRGALV 122 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL-GLESRIR 184 GTSS+RR + RPD+ + LRGNV TR++K+ G+YDA I+AVAG+ RL G I+ Sbjct: 123 GTSSVRRAEFVKAIRPDVRVEPLRGNVDTRINKILQGKYDAAIMAVAGIYRLYGASPPIK 182 Query: 185 -AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 A L PE+ P GQG V R DS +LL + + +L AER + GC Sbjct: 183 LAVLRPEVLPPPPGQGIVAAVVREADSWLIDLLKKASDPKASLEAIAEREFLKAVGAGCH 242 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 V IG A + + A + G + G D ++G AEE+ Sbjct: 243 VAIGGVAFARNDTVEFIAGYAS--GGRKYIVRVVG--DDPVEVGRRAAEEIRK 291 >UniRef50_Q2NEP4 HemC n=4 Tax=Methanobacteriaceae RepID=Q2NEP4_METST Length = 290 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 90/292 (30%), Positives = 148/292 (50%), Gaps = 4/292 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 + + TR S LA Q V L + E + T GD I ++ L + KG+F KE Sbjct: 1 MIVGTRGSKLATTQTKTVVKALEEITGEEI-ETKIIKTTGDKIKNSQLYNIDAKGIFTKE 59 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L+ AL++ D AVHS KD+P E L + I +RE + +SN S D LP + + Sbjct: 60 LDTALIDGSIDFAVHSFKDLPSELNDQLTITAIPQREAINEVLISN--YSWDELPENATL 117 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR+ + + +RGN+ TR+ K++ GEYDA I+A+AG+ RLGL+ I+ Sbjct: 118 GTSSVRREAFCKLHGKKIQTKPIRGNIDTRIRKVEEGEYDATIMALAGINRLGLQEHIKE 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 + P GQGA+ + DS ++++ LNH ++ + E+A+ + GCQ P Sbjct: 178 VFDEQYITPPAGQGALAVMTHK-DSEYNDVISKLNHEDSRIEAMTEKAILETIGVGCQWP 236 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 IG +++ I + + +P+G + + +A + +L + Sbjct: 237 IGIVSKVDGNNINIHCKLLSPEGKLLADVNKTTDKNNAINTAKVIGTKLRED 288 >UniRef50_Q9F7M2 Predicted porphobilinogen deaminase n=2 Tax=Bacteria RepID=Q9F7M2_PRB01 Length = 303 Score = 321 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 111/306 (36%), Positives = 173/306 (56%), Gaps = 4/306 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +RIATRQS LA++QA +V D+L+A + VELVPM + GD D PL ++GGKGLF+ Sbjct: 2 KIRIATRQSELAMYQAKFVADELLAKINNIKVELVPMTSEGDQ-TDKPLHEIGGKGLFIS 60 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 LE +L + ADIAVHS+KDVP + ++++ RE P D +S + S S Sbjct: 61 TLESSLEADEADIAVHSLKDVPAKLDPKFKIISVFSRESPEDLLLSKDGKSFSEFARNST 120 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTS RR+ Q+ RPD+ +RGN+ TR+ KL++G +D +++A A +KRLGL+ Sbjct: 121 IGTSGPRRKAQINNLRPDIKTIPVRGNIATRIKKLNDGLFDGLVVAKAAIKRLGLKQNSY 180 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 E LP+ QG + IEC D ELL + + + +AER+ +EG C Sbjct: 181 E-FSIEEMLPSASQGYIAIECLSDKKDIIELLENIGDPKELILASAERSFVAAMEGTCLS 239 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 PI E +G+I + + + +G++ I E+ + QD + A+E + GA+ ++ Sbjct: 240 PIAILCEDKNGQIKISGKILSYEGNEKIYKEKISSFQDIAIDIMLFADEFILEGAKSLI- 298 Query: 305 EVYNGD 310 + N + Sbjct: 299 -LKNDN 303 >UniRef50_C6R3Y0 Hydroxymethylbilane synthase n=1 Tax=Rothia mucilaginosa ATCC 25296 RepID=C6R3Y0_9MICC Length = 377 Score = 320 bits (821), Expect = 4e-86, Method: Composition-based stats. Identities = 135/372 (36%), Positives = 187/372 (50%), Gaps = 71/372 (19%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLV------------VELVPMVTRGDVI 48 M + + TR S LAL Q+ + + + + EL + T GD + Sbjct: 1 MSHHEYTLGTRGSALALTQSRIAAETVTSLYTEHQAHHGAENPEAVSFELRTVKTEGD-V 59 Query: 49 LDTPLAKVGGKGLFVKELEVALLEN-------RADIAVHSMKDVPVEFPQGLGLVTICER 101 L PLA +GG G+F L LL+ R D+AVHS+KD+P GL + +R Sbjct: 60 LTGPLATLGGTGVFAAALRQRLLDGENASEENRVDMAVHSLKDLPSAPCPGLVVAATLKR 119 Query: 102 EDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-- 159 EDPRDA V+ + ++D LP GS VGT S RR QL RPDL I +RGNVGTR+ ++ Sbjct: 120 EDPRDALVARDGLTVDTLPEGSRVGTGSPRRAAQLRALRPDLEIVDVRGNVGTRIGRVKG 179 Query: 160 ----------------------------DNGEYDAIILAVAGLKRLGLESRIRAALPPEI 191 +G+ DA++LAV+GLKRLG E I L P Sbjct: 180 LEEHAGKQVVLRQNAETSERADHGVGTERSGDCDAVVLAVSGLKRLGKEELITEYLDPTR 239 Query: 192 SLPAVGQGAVGIECRLD-----------DSRTRELLAAL-------NHHETALRVTAERA 233 LPA GQGA+ +E R D + AL NHHET L V+AERA Sbjct: 240 MLPAPGQGALALEVRESEFENPDSAVLADPEVARPVRALGRALLAANHHETRLAVSAERA 299 Query: 234 MNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---AEQMGISL 290 + RLE GC PIG+YA +++G++ L +V +PDG+ ++R A D AE++G+ + Sbjct: 300 LLRRLEAGCAAPIGAYAHVVEGDLVLNVVVASPDGTDMLRHTSATAELDVPGAERLGVRV 359 Query: 291 AEELLNNGAREI 302 AE+LL GA + Sbjct: 360 AEDLLQMGAAAL 371 >UniRef50_D1VCA1 Porphobilinogen deaminase n=1 Tax=Frankia sp. EuI1c RepID=D1VCA1_9ACTO Length = 380 Score = 320 bits (821), Expect = 4e-86, Method: Composition-based stats. Identities = 123/343 (35%), Positives = 178/343 (51%), Gaps = 44/343 (12%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + LR+ TR+S LAL Q+ V D+L G+ V+LV +VT GD ++++G G++ Sbjct: 37 PSRLRLGTRRSALALAQSGMVADELRTRL-GIEVDLVHVVTEGDRNR-AEISQLGSTGVW 94 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 V L ALL D+AVHS+KD+P P+G+ L I RED RD VS +L L G Sbjct: 95 VSALREALLSGEVDLAVHSLKDLPTAPPEGITLAAIPPREDVRDVLVSPTGRTLAQLGPG 154 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 + +GT + RR QL L + +RGNV TR+ K +GE DA++LA AGL RL Sbjct: 155 ARIGTGAPRRAAQLRALGLGLDVVPIRGNVDTRIKKAIDGEVDAVVLARAGLARLDRLDA 214 Query: 183 IRAALPPEISLPAVGQGAVGIECRL--------------DDSR----------------- 211 I L PE+ LPA GQGA+ IEC +D Sbjct: 215 ITELLEPEVMLPAPGQGALAIECVATTLAPLTLLTVGTPEDQGAVTGMSCPVAPGSGVEI 274 Query: 212 -TRELLAA-LNHHETALRVTAERAMNTRLEGGCQVPIGSYAEL---------IDGEIWLR 260 LL L+ +++ V AERA +E GC P+G+ A++ +GE+ LR Sbjct: 275 PLERLLRFVLDDAPSSVAVRAERAFLAAIEAGCTAPVGALAQVLPARGQAPASEGEVRLR 334 Query: 261 ALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 A+V + DG+ ++R E G+ D E +G LA++LL+ GA ++ Sbjct: 335 AVVASLDGTTVLRRELGGSTADPEALGRRLADDLLSAGAHTLM 377 >UniRef50_Q57989 Probable porphobilinogen deaminase n=11 Tax=Methanococcales RepID=HEM3_METJA Length = 292 Score = 320 bits (820), Expect = 5e-86, Method: Composition-based stats. Identities = 106/296 (35%), Positives = 156/296 (52%), Gaps = 10/296 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LAL+QA+ V + L G VE+ + T GD +LD L+ +G G+F KE Sbjct: 2 IRIGTRGSKLALYQANKVAELLKNL--GYKVEIKIIKTTGDRVLDKKLSDIG-IGVFTKE 58 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L++A+L N DIAVHS+KD+P + + L + + ER+ D + N + + ++ Sbjct: 59 LDLAMLNNEIDIAVHSLKDIPTIWNENLMVGAVLERDSYHDLLIWNKDIDFNE-DSKIVI 117 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR+ L P+ LRGNV TRL KL G YDAI+L+ AG+ RLG+ Sbjct: 118 GTSSMRRRAFLKFIYPNAKFELLRGNVDTRLRKLKEGLYDAIVLSEAGIIRLGVSLEDFN 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 +I LPA QG + + C+ DD + +L +NH T L ER GGC VP Sbjct: 178 YKRLDI-LPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSVP 236 Query: 246 IGSYAELIDGE--IWLRALVGAPDGSQIIRGERRGAPQD---AEQMGISLAEELLN 296 G+ A + + L+A V D + GE + + A ++G + +L N Sbjct: 237 FGALAVYDEKNELLKLKAAVVTNDELKNASGEVKCKIDEIDKAVELGKKIGLKLKN 292 >UniRef50_A0QLI0 Porphobilinogen deaminase n=69 Tax=Actinomycetales RepID=HEM3_MYCA1 Length = 315 Score = 318 bits (815), Expect = 2e-85, Method: Composition-based stats. Identities = 133/311 (42%), Positives = 175/311 (56%), Gaps = 13/311 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LA QA V+D L+A G ELV + T GD P+ +G G+F Sbjct: 2 IRIGTRGSLLATTQAGGVRDALIAR--GHPAELVTITTAGDR-SSGPIESLG-VGVFTTA 57 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L A+ E R D AVHS KD+P + I R DPRDA V+ + L LP GS+V Sbjct: 58 LREAIEEGRVDAAVHSHKDLPTADDPRFAVAAIPARNDPRDAVVARDGLVLGELPPGSLV 117 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS RR QL L IR LRGN+ TRL+++ +G+ DAI++A AGL RLG + Sbjct: 118 GTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLGDVTE 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L P LPA QGA+ +ECR DSR +LA L+ +T VTAERA+ LE GC P Sbjct: 178 TLEPVQMLPAPAQGALAVECRAGDSRLAAVLAELDDADTRASVTAERALLAELEAGCSAP 237 Query: 246 IGSYAELID---------GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 +G+ AE+++ E+ LR V A DGS +IR G P A ++G+S+A EL Sbjct: 238 VGAIAEVVESIDEDGRIFEELSLRGCVAALDGSDVIRASGIGTPGRARELGLSVAAELFE 297 Query: 297 NGAREILAEVY 307 GARE+++ Sbjct: 298 LGARELMSGAR 308 >UniRef50_UPI0001BC2D4C glutamyl-tRNA reductase n=1 Tax=Brevibacterium linens BL2 RepID=UPI0001BC2D4C Length = 825 Score = 318 bits (815), Expect = 2e-85, Method: Composition-based stats. Identities = 116/340 (34%), Positives = 171/340 (50%), Gaps = 30/340 (8%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 +R+ TR+S LA Q+ + +L A G VE+V +VT GDV + +PL GG G+ Sbjct: 475 SGRTIRLGTRRSKLARSQSTAIAHQLAAL-TGWRVEIVEVVTEGDVNM-SPLTGFGGTGV 532 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FV + AL + + DIAVHS+KD+P G+ + I R DP D + + S LPA Sbjct: 533 FVSAVRQALHQGKIDIAVHSLKDLPTTPEAGIQMAAIPPRVDPADVLIGRDGLSFAELPA 592 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 GS+VGT S RR QL RPD+ +R +RGNV TR++ + +G DA++LA AG++R+G + Sbjct: 593 GSVVGTGSPRRAVQLRAARPDIEVRGVRGNVDTRIAHVRDGRLDAVVLAAAGVRRIGRLA 652 Query: 182 RIRAALPPEISLPAVGQGAVGIECR-------------LDDSRTRELLAALNHHETALRV 228 +L + LPA GQGA+ +E R D+ R L L+ T L V Sbjct: 653 EATDSLDFDTMLPAPGQGALAVETRGADSPFALDNEVMEADAEVRTQLKRLHDETTDLAV 712 Query: 229 TAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER------------ 276 T ERA+ +R E GC PIG+ A + + + A++ DG + Sbjct: 713 TCERAILSRAEAGCSAPIGALATIQGSDFVVDAVMADDDGKLARTRQVAPLPTTPDVDLD 772 Query: 277 RGAPQDAEQMGISLAE---ELLNNGAREILAEVYNGDAPA 313 G+ G LA EL A ++L ++ A + Sbjct: 773 SGSANQLSITGKELARLADELGTAAAEDLLGQLGIDPAQS 812 >UniRef50_Q8D2W2 HemC protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis RepID=Q8D2W2_WIGBR Length = 291 Score = 317 bits (814), Expect = 2e-85, Method: Composition-based stats. Identities = 132/289 (45%), Positives = 193/289 (66%), Gaps = 1/289 (0%) Query: 20 AHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAV 79 + K KL+ HP L ++LVP++T GD+I KGLF+KELE +LL+ ++DIAV Sbjct: 3 SKLCKKKLLHYHPKLNIKLVPILTTGDLINKIRNNITNEKGLFIKELEKSLLKYQSDIAV 62 Query: 80 HSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAER 139 HSMKD F LGL IC+R+DPRDA VSN Y+++ +LP + VGTSSLRR+CQL Sbjct: 63 HSMKDFSSSFLDSLGLAAICKRDDPRDAIVSNYYNNIISLPNNAKVGTSSLRRKCQLLSI 122 Query: 140 RPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQG 199 RPDL I +GN+ +RL KL+ G +DA+ILA A LKRL + ++ + P LPA+GQG Sbjct: 123 RPDLKIFPCKGNIHSRLKKLNQGVFDALILATAALKRLKINEQMYTPIDPSYLLPAMGQG 182 Query: 200 AVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID-GEIW 258 ++ I+CRL D++ +++ +N+ +TAL + +E+ + + L GC+VPIGSYA++ + IW Sbjct: 183 SIAIQCRLYDNKIIDIVRNINNKKTALCINSEKIVVSMLGTGCRVPIGSYAKIENKNTIW 242 Query: 259 LRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVY 307 +RALVG+ DGS IIR E + +AE++ + L+N GA+ IL + Sbjct: 243 IRALVGSIDGSNIIRSEGKSCVSNAEKLSKKQVKNLINLGAKNILKKFK 291 >UniRef50_D1C4S0 Porphobilinogen deaminase n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C4S0_SPHTD Length = 311 Score = 317 bits (814), Expect = 3e-85, Method: Composition-based stats. Identities = 124/299 (41%), Positives = 161/299 (53%), Gaps = 2/299 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +R+ TR S LA Q V L A P L + + T GD TPL +GG+G+F +E Sbjct: 11 VRLGTRGSALAREQTRRVMAALAALRPDLELIETIVSTAGDRDKRTPLTVIGGQGVFARE 70 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L+ ALL D+AVHS KD+P E GL + RED RD VS + SL LP G+ V Sbjct: 71 LQTALLAGTVDVAVHSAKDLPTEPVPGLVIGAFFSREDARDVLVSRDGRSLADLPPGARV 130 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS RR L RPDL LRGN+ TRL K+ GE DA ILA AGL R+G + I Sbjct: 131 GTSSRRRLVALRRLRPDLEAVDLRGNLDTRLRKVREGEVDAAILAAAGLLRMGWQEHITE 190 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L + +PA GQGA+ IECR DD E+LAALN AL ER+ L GGC+ P Sbjct: 191 FLSLDDFVPAPGQGALAIECRADDPAVNEMLAALNDPAAALAARTERSFLRALGGGCRSP 250 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN--NGAREI 302 IG++A + + LR ++G +++ +AE +LA E+ GA + Sbjct: 251 IGAHATVSGDTVTLRVMLGDEAMTRVRLSTWTLPAAEAETRAGALAVEVQRSLAGADPL 309 >UniRef50_A1DGB8 Porphobilinogen deaminase n=1 Tax=Neosartorya fischeri NRRL 181 RepID=A1DGB8_NEOFI Length = 363 Score = 317 bits (812), Expect = 5e-85, Method: Composition-based stats. Identities = 120/342 (35%), Positives = 162/342 (47%), Gaps = 39/342 (11%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKL-MASHPGLVVELVPMVTRGDVILDTPLAKVG---- 57 + V+ R+S LAL Q +V KL P ++ GD P A + Sbjct: 20 EEVVIFGCRKSELALVQTRWVTSKLGQTLDPSPTFQIATGSAVGDADKQAPFAVLSKLTG 79 Query: 58 ----GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN-- 111 GK L+ ELE+ L+ + VHS+KD+P P L + ERED DA Sbjct: 80 GSDIGKSLWTNELELDLVAGKVHCLVHSLKDMPTTLPPHCLLGAVPEREDCSDAVCMRSD 139 Query: 112 -NYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAII 168 + S+D LP GSIVGTSS RR+ + P L + RGNV TRL+KLD + I+ Sbjct: 140 LKFTSIDQLPPGSIVGTSSSRRKALVRRNWPHLEVVECRGNVDTRLAKLDAPSSRFSCIL 199 Query: 169 LAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRV 228 LA AGL RLGL RI L I AVGQGA+G+E D EL+ ++H + R Sbjct: 200 LATAGLLRLGLGHRITHRLDDSIFPYAVGQGALGLEVSTDRPDILELVRHVDHKPSRWRG 259 Query: 229 TAERAMNTRLEGGCQVPIGSYAELI----------------------DGEIWLRALVGAP 266 AERAM L+GGC PIG + L G + LRA+V Sbjct: 260 IAERAMLRSLQGGCSSPIGVQSSLEPLGKEENGSTEDDSQRGRDSSSGGNLSLRAMVLHI 319 Query: 267 DGSQIIRGERRGAP---QDAEQMGISLAEELLNNGAREILAE 305 +G+ I E ++AE +G+S+A LL GAR ++ + Sbjct: 320 EGTSEIVAEDMATVRCDEEAELLGVSVANMLLAKGARGLMPK 361 >UniRef50_B3LB83 Porphobilinogen deaminase, putative n=1 Tax=Plasmodium knowlesi strain H RepID=B3LB83_PLAKH Length = 449 Score = 316 bits (810), Expect = 8e-85, Method: Composition-based stats. Identities = 102/382 (26%), Positives = 168/382 (43%), Gaps = 73/382 (19%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHP----GLVVELVPMVTRGDVILDTPLAKVGGK 59 + I TR SPLA+ Q+ V+ KL A + + L + T GD ILD + GGK Sbjct: 65 KEIIIGTRDSPLAIKQSEKVRTKLEAYFKKVNKNVKITLKSIKTMGDNILDQKVDLFGGK 124 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 G+F KEL+ L++ + I VHS+KDVP+E P+ + L +R+ DAF+S Y +L+ + Sbjct: 125 GIFTKELDEELIKGKVHICVHSLKDVPMELPEQVQLSCFLKRDTINDAFLSVKYGTLEDM 184 Query: 120 ---------------PAGS------------------------IVGTSSLRRQCQLAERR 140 P G +GTSSLRR Q+ + Sbjct: 185 NKMKMANKMEEGSYQPKGMSQRVINQNVKRDNYEGDHYDNFIPTIGTSSLRRSSQIKYKY 244 Query: 141 PDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL----------------------- 177 ++ ++++RGN+ TR++KL NG+YDAII+A GL+RL Sbjct: 245 KNVAVKNMRGNINTRIAKLCNGQYDAIIIAKCGLERLTTKKGIRNIIGGKNKVTPKNFLI 304 Query: 178 -------GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTA 230 L S + PA+ QG + + D ++L +N + + Sbjct: 305 NYNNTEINLTSLHIQQINKRTIYPALCQGIIAVSSHKSDKYISDVLKNINDEKAQIMANI 364 Query: 231 ERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISL 290 ER+ ++EG C +PIG YA++++GEI A++ G + G + ++ + Sbjct: 365 ERSFLYQIEGNCMMPIGGYAKIVNGEIVFNAVINDIHGREKYHVREVGKVESYNEIAVMA 424 Query: 291 AEELLNNGAREILAEVYNGDAP 312 A ++ ++ A Sbjct: 425 ATKMKEKIGTHRFNKIREEAAQ 446 >UniRef50_C5CB88 Porphobilinogen deaminase n=5 Tax=Actinomycetales RepID=HEM3_MICLC Length = 377 Score = 315 bits (808), Expect = 1e-84, Method: Composition-based stats. Identities = 129/356 (36%), Positives = 178/356 (50%), Gaps = 61/356 (17%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 + LRI TR S LA Q +V + L A GL ELV + T GD + LA +GG G+F Sbjct: 2 SPLRIGTRGSALATTQTSHVAEALTARS-GLAHELVVIRTEGD-VTTGSLASLGGTGVFA 59 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 L A+L+ D AVHS+KD+P P+ L + + R D RDA + + +L LP G+ Sbjct: 60 SALRAAVLDGVVDAAVHSLKDLPAAQPETLEIAAVPARADLRDALCARDGLTLATLPEGA 119 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL----------------DNGEYDAI 167 VGT S RR QL RPDL + +RGNV TRL+++ G+ DA+ Sbjct: 120 RVGTGSPRRVAQLKALRPDLELVDIRGNVQTRLARVPGLEQHDDHAPAAVGSPRGDLDAV 179 Query: 168 ILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDS---------------RT 212 ILA AGL RLGL+ I + PE+ +PA GQGA+ +E R +D R Sbjct: 180 ILACAGLDRLGLDHVITERIDPEVMVPAPGQGALAMEIRAEDESFLGRALLDPEAPVGRL 239 Query: 213 RELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDG-----EIWLRALVGAPD 267 L ++ +T + VTAERA+ RLE GC PIG+ A + DG I + A+V A D Sbjct: 240 HAALELVDDRDTHVAVTAERALLRRLEAGCAAPIGAVARVGDGEAGAPRIEMTAMVAALD 299 Query: 268 GSQIIRGE-----------RRGAPQ------------DAEQMGISLAEELLNNGAR 300 GS+++R G P AE +G+ +AE+ + GA Sbjct: 300 GSRVLRRTSSVQLDPVPADVVGDPAAADEWLEDTLFVAAEALGVHVAEQFVAEGAD 355 >UniRef50_Q1EPC8 Porphobilinogen deaminase, chloroplast (Hydroxymethylbilane synthase) (Pre-uroporphyrinogen synthase), putative n=1 Tax=Musa acuminata RepID=Q1EPC8_MUSAC Length = 328 Score = 315 bits (807), Expect = 2e-84, Method: Composition-based stats. Identities = 126/299 (42%), Positives = 163/299 (54%), Gaps = 34/299 (11%) Query: 11 RQSPLALWQAHYVKDKLMASHPGLV----VELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66 R S LAL QA +DKL A+H L VE++ + T GD+ILD PLA +GGKGLF KE+ Sbjct: 54 RDSDLALAQARETRDKLKAAHSELAEEGAVEIIIIKTTGDMILDKPLADIGGKGLFTKEI 113 Query: 67 EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126 + ALL+ R DIAVHSMKDVP P+G L Sbjct: 114 DDALLQGRIDIAVHSMKDVPTYLPEGTILPCNLP-------------------------- 147 Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAA 186 +SLRRQ Q+ R P L + +LRGNV TRL+KL NG+ A +LA+AGLKRL + + + Sbjct: 148 -ASLRRQSQILCRYPSLKVVNLRGNVQTRLTKLKNGDVHATLLALAGLKRLNMVENVTSI 206 Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246 L E LPAV QGA+GI CR +D++ E L++LNH +T V ER T L+G C+ PI Sbjct: 207 LSMEEMLPAVAQGAIGIACRSNDNKMMEYLSSLNHEDTRSAVACEREFLTVLDGNCRTPI 266 Query: 247 GSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAP--QDAEQMGISLAEELLNNGAREI 302 +YA DG R L+ +PDGS++ R G D +MG EL Sbjct: 267 AAYAHRDKDGSCSFRGLLASPDGSKVYETTRIGPYSFDDMVEMGKDAGHELKAKAGPGF 325 >UniRef50_O26960 Probable porphobilinogen deaminase n=1 Tax=Methanothermobacter thermautotrophicus str. Delta H RepID=HEM3_METTH Length = 289 Score = 314 bits (806), Expect = 2e-84, Method: Composition-based stats. Identities = 102/286 (35%), Positives = 153/286 (53%), Gaps = 4/286 (1%) Query: 9 ATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEV 68 TR S LAL Q ++V + L + + + +GD I D+ L + +GLF +EL++ Sbjct: 4 GTRGSRLALVQTNHVIEMLSEVCKEKIEKKIIKT-KGDRIRDSQLYSMDSRGLFTRELDM 62 Query: 69 ALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTS 128 A+L D+AVHS+KDVP + L + + RE P + VS + LP GS +GTS Sbjct: 63 AVLNEEVDLAVHSLKDVPSDLDPDLAIAAVPPRESPAEVLVSR--LDWEDLPQGSKLGTS 120 Query: 129 SLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALP 188 SLRR+ + + + LRGN+ TR+ K+ +GE A I+A AGLKRLGLE I+ P Sbjct: 121 SLRREAFCNHHQKNFKMEPLRGNIDTRIRKVMDGEVHATIMAEAGLKRLGLEEHIKRRFP 180 Query: 189 PEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGS 248 E PA GQGA+ + R DS + + HH + VTAE+ + L GCQ P+G Sbjct: 181 VEYFTPAAGQGALAVITRA-DSELISSIGRITHHPSLQEVTAEKTLLRELGAGCQCPLGV 239 Query: 249 YAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 ++ L A++ +G + + RG +AE +G A+E+ Sbjct: 240 IGRATGNQLTLYAVLLTREGEMLRKVTVRGPLAEAEDIGKKAAKEM 285 >UniRef50_C9RPT6 Porphobilinogen deaminase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RPT6_FIBSS Length = 351 Score = 314 bits (806), Expect = 2e-84, Method: Composition-based stats. Identities = 128/352 (36%), Positives = 171/352 (48%), Gaps = 57/352 (16%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHP-------------GLVVELVPMVTRGDV 47 M D LRIATR+S LAL Q D ++A++ L ELV M T GD Sbjct: 1 MSDLKLRIATRKSALALAQTTMAADAIVAANSVIGNAADSNNARDSLTYELVSMTTEGDR 60 Query: 48 ILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDA 107 LD LA GGKG+F+KELE+ALLE RADIA+HS+KD+P E L + +REDPRDA Sbjct: 61 RLDKSLASFGGKGVFIKELEIALLEGRADIAIHSLKDMPAEVLPQFKLAAVLKREDPRDA 120 Query: 108 FVSNNYD---SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY 164 F+S LPAG+ VGT S+RR QL RPDL +RGN+ TR+ KL E Sbjct: 121 FLSRGGSAGIRFMDLPAGARVGTGSIRRVVQLKALRPDLEYVPIRGNIQTRIGKLA--EL 178 Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLD----------DSRTRE 214 D ++LA AGLKR+GL ++ E LPA GQG + IE D + + Sbjct: 179 DGVVLAAAGLKRMGLADQVTEYFSTEQMLPASGQGILAIETLNDATVQESRVTGRADLAQ 238 Query: 215 LLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDG------------------- 255 +LA +N T +AE A L GCQ P+ S+AE + Sbjct: 239 ILARVNDVATYCIASAEMAYLKALNAGCQFPVASFAEFVCEDGIENRGTCGALEENANRI 298 Query: 256 --EIWLRALVGAPDGSQIIRGERRGAPQ--------DAEQMGISLAEELLNN 297 + +R + +++R E G ++ +GI LA + Sbjct: 299 AQTLKIRGIYWDEKSEKLLRAEVAGNVDLNSEDCVQQSKNLGIELACAIQKQ 350 >UniRef50_B6JII8 Porphobilinogen deaminase n=11 Tax=Bradyrhizobiaceae RepID=B6JII8_OLICO Length = 338 Score = 313 bits (803), Expect = 5e-84, Method: Composition-based stats. Identities = 112/323 (34%), Positives = 160/323 (49%), Gaps = 18/323 (5%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG-L 61 D +RI TR+S +AL Q + +L A+ P L VE+V T GD L +GGKG Sbjct: 11 DKAMRIGTRKSVMALAQTSEIARQLTAADPALDVEIVKFETTGDQDQTGKLLDLGGKGGA 70 Query: 62 FVKELEVALLENRADIAVHSMKDVPV-EFPQGLGLVTICEREDPRDAFVSNNYDSLDAL- 119 FV ++ A+ E R + A+HS+KD+P E GL + R+ P DA V + +L L Sbjct: 71 FVAQIRDAVREGRLEAAMHSLKDMPGNEDTPGLVIGATLTRDPPTDALVVRHGVTLADLR 130 Query: 120 ---PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE------------Y 164 G +GT+++RR + P+ I RG TR+ KLDNGE Sbjct: 131 RTGGKGFKIGTNAVRRAAYVRRLFPECEIIHFRGAADTRIRKLDNGEKQRLPEGGEVGPA 190 Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224 DA+++A AGL+R+G RI P+ LPAVGQG V +EC D T LA ++ + Sbjct: 191 DALVMAQAGLERVGCADRIAHCFSPDEILPAVGQGIVAVECAASDWCTLARLAQIDDPVS 250 Query: 225 ALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAE 284 AER + L G C PI YA + ++ L+A V I RRG Sbjct: 251 RCCAAAEREVLWVLNGHCNSPIAGYAIVEGDDVLLKAAVLDEANDHFIEVTRRGPASRPR 310 Query: 285 QMGISLAEELLNNGAREILAEVY 307 ++G ++A ELL GA +++A Sbjct: 311 ELGRAVAFELLAKGAADVIARTR 333 >UniRef50_Q6AHF1 Porphobilinogen deaminase n=5 Tax=Actinobacteria (class) RepID=HEM3_LEIXX Length = 329 Score = 312 bits (799), Expect = 1e-83, Method: Composition-based stats. Identities = 115/310 (37%), Positives = 158/310 (50%), Gaps = 15/310 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LR+ TR SPLA+ Q V + + G +ELV + T GD + L+++GG G+F Sbjct: 15 LRVGTRGSPLAVAQTQAVSAAVARA-TGFDIELVTVTTHGDTSRE-SLSELGGTGVFATA 72 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L AL D+ VHS+KD+P GL L + +R D RD + + LP G+ V Sbjct: 73 LRDALRNGECDLVVHSLKDLPTAPAPGLVLGAVPKRADARDTLCARDGLRFGELPEGASV 132 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT S RR QL +RP L I +RGNV TRLS++ G+ DA++LA AGL RLG Sbjct: 133 GTGSPRRAAQLRAQRPGLDIVDIRGNVDTRLSRVSAGDLDAVVLAAAGLGRLGRLDAATD 192 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSR----TRELLAALNHHETALRVTAERAMNTRLEGG 241 A GQGA+ +E R D R LAA++H T TAERA+ LE G Sbjct: 193 FFSLSTMPTAPGQGALALEVREGDERGRGPIARALAAVDHATTCAATTAERAVLAGLEAG 252 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---------AEQMGISLAE 292 C P+G+ A + DG ++L A V PDG+ + P A +G + Sbjct: 253 CAAPVGATAMIDDGLLFLTATVYRPDGAAQLTASHAATPDSFGAAHLDEAARDVGERVVA 312 Query: 293 ELLNNGAREI 302 ELL +GA ++ Sbjct: 313 ELLASGAADL 322 >UniRef50_C5EV71 Pyruvate ferredoxin/flavodoxin oxidoreductase n=3 Tax=Clostridiales RepID=C5EV71_9FIRM Length = 301 Score = 310 bits (796), Expect = 3e-83, Method: Composition-based stats. Identities = 117/304 (38%), Positives = 163/304 (53%), Gaps = 13/304 (4%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + N++RI TR+S LAL Q H + D L + P + VELV T GD ILD PL + GGKG+ Sbjct: 1 MSNIIRIGTRKSALALIQTHLIADGLKRAWPDIEVELVTKETLGDKILDKPLQEFGGKGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FV E E A+ E D+AVHS KD+P+E +GL + + R DPRD V+ D Sbjct: 61 FVSEFEQAMKEGAIDLAVHSAKDLPMELGEGLVIAAVSGRGDPRDVLVTMKGSPKDR--E 118 Query: 122 GSIVGTSSLRRQCQLAERRP-------DLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174 ++GTSS RRQ + E R L +LRGNV TRL KL+ G YD IILA AGL Sbjct: 119 HIVIGTSSPRRQLEAVEYRGQLWPGAASLTCATLRGNVHTRLRKLEEGLYDGIILAAAGL 178 Query: 175 KRLGLESRIRA---ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231 +RL L L P + +PA GQG + +E R R L A++ E L +T E Sbjct: 179 ERLDLLGNPSYDFKYLDPTVFIPAGGQGIMAVEAREGSDAAR-LCQAIDSREGRLCLTLE 237 Query: 232 RAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLA 291 R + L+ GC PIG Y+ ++DG++ + + ++ I E ++ E + + Sbjct: 238 RMVLKLLDAGCHEPIGIYSNIMDGKMEVWGISRPDRVTRRISLEGAVTEKELEALALQAG 297 Query: 292 EELL 295 L+ Sbjct: 298 RGLM 301 >UniRef50_A3VPD5 Porphobilinogen deaminase n=1 Tax=Parvularcula bermudensis HTCC2503 RepID=A3VPD5_9PROT Length = 324 Score = 310 bits (794), Expect = 5e-83, Method: Composition-based stats. Identities = 135/286 (47%), Positives = 178/286 (62%), Gaps = 6/286 (2%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMAS------HPGLVVELVPMVTRGDVILDTPLA 54 M LRIA+R+SPLA+ QA +V+D+L + VT GD +L+ LA Sbjct: 1 MSFKPLRIASRRSPLAVAQALWVRDRLAEALGIDEVDRDAAFPHETFVTTGDRMLNPTLA 60 Query: 55 KVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD 114 +GGKGLF KE+E+ALL+ +ADIAVHSMKD+P + P GL L + REDPRDAFV+ + Sbjct: 61 DIGGKGLFTKEIEIALLDGQADIAVHSMKDMPAQMPPGLVLAAVPVREDPRDAFVTLDGR 120 Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174 LD +PAG+ +GTSS RR+ QLA RPDL + +RGNVGTRL KL GE + LA AGL Sbjct: 121 PLDQMPAGARIGTSSTRRRAQLARLRPDLALVPMRGNVGTRLQKLAAGEAEGTFLAEAGL 180 Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234 +RLG+ R AL P LPA+GQGA+ ++ R D T A +N+ TAL AERA+ Sbjct: 181 RRLGMTDVKREALSPARMLPALGQGALCVQARSGDHETLSACAHINNRPTALAAAAERAL 240 Query: 235 NTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAP 280 + L+G C+ PIG A + L + PDG +++RGER A Sbjct: 241 ISGLDGSCKTPIGGLARQTGDSLILEGQILTPDGRRVLRGERTVAI 286 >UniRef50_A6LKX0 Porphobilinogen deaminase n=1 Tax=Thermosipho melanesiensis BI429 RepID=A6LKX0_THEM4 Length = 279 Score = 308 bits (791), Expect = 1e-82, Method: Composition-based stats. Identities = 95/272 (34%), Positives = 147/272 (54%), Gaps = 9/272 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +R+ TR+S LAL Q V +KL P + E+ P+VT+GD L TP+ K+GGKG+FV Sbjct: 2 KIRVGTRKSKLALIQTQLVVNKLKELLPNIDFEITPVVTKGDR-LKTPIDKIGGKGVFVS 60 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 ++E +L+++ DIA+HSMKD+P + P L L ++ +RE P D F+ + L G+ Sbjct: 61 DIEKLILDDKLDIAIHSMKDLPSKIPDKLFLTSVLKRECPNDVFIGKE--NFFNLKKGAK 118 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSS RR Q+ RPD+ I +RGNV TR+ K+ GE D I++A AG+ RLGL+ +I Sbjct: 119 IGTSSKRRALQINMLRPDIEIVPIRGNVDTRIKKI--GELDGIVIAAAGVIRLGLKDKIT 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAA-LNHHETALRVTAERAMNTRLEGGCQ 243 E +PA QG + +E + E + + +T + ER + + L C Sbjct: 177 NLFEFEKIVPAPCQGILALEFSEKFLKPFEEIKDVIVDPKTEVETQIERKILSLLNFDCN 236 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGE 275 P G Y + + + + + E Sbjct: 237 TPFGFYCDASK---KVTCYMFKNNERKKFTFE 265 >UniRef50_B2ULP1 Porphobilinogen deaminase n=1 Tax=Akkermansia muciniphila ATCC BAA-835 RepID=B2ULP1_AKKM8 Length = 325 Score = 308 bits (790), Expect = 1e-82, Method: Composition-based stats. Identities = 121/317 (38%), Positives = 155/317 (48%), Gaps = 21/317 (6%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG---- 57 N L I TR S LAL QA V+ L +P L V + T GD D PLA V Sbjct: 3 SKNTLIIGTRGSALALAQADMVRAALSLRYPELDVRCEIIHTIGDRRTDVPLADVARVSG 62 Query: 58 --GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS 115 KG+F+KELE AL + R D+AVHS+KDVP E G L + R D ++ D Sbjct: 63 MVDKGIFIKELETALRDGRIDVAVHSLKDVPSELAAGFTLAAVLPRAAVEDVLITKEPDW 122 Query: 116 LDALPAGSIVGTSSLRRQCQLAERR-PDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAG 173 + + T S+RR+ L +LRGNV TRL KL +DA+ILA AG Sbjct: 123 NGS----GTLATGSVRRRLMARTYWGSGLRFENLRGNVPTRLGKLVEHPGWDAVILARAG 178 Query: 174 LKRLGLESRIR---------AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224 L+RLGL + LP E+ +PAVGQG VG+ECR D T E+L +N E+ Sbjct: 179 LERLGLYAPETLVEGRKLYMRPLPVEVFIPAVGQGIVGMECRSSDRETAEMLEGINDPES 238 Query: 225 ALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAE 284 AERA RL C P+G YA E+ LRA P + RG + E Sbjct: 239 FACALAERAFLVRLGANCSTPVGVYAHPDGEELVLRAAYYVPGREEPFAVVIRGDRKAPE 298 Query: 285 QMGISLAEELLNNGARE 301 +G+ EEL +G R+ Sbjct: 299 ALGLRAFEELGLSGWRK 315 >UniRef50_A8PWJ5 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8PWJ5_MALGO Length = 530 Score = 307 bits (788), Expect = 3e-82, Method: Composition-based stats. Identities = 131/394 (33%), Positives = 187/394 (47%), Gaps = 92/394 (23%) Query: 5 VLRIATRQSPLALWQAHYV------------------------------KDKLMASHPG- 33 L +++R+S LA+ QA V + L P Sbjct: 89 TLVLSSRKSELAVRQATQVQMLLDTRYGRASPVFAPGADQWPSTEVANIRAFLRTFSPDQ 148 Query: 34 -----LVVELVPMVTRGDVILDTPLAKVGGKG--LFVKELEVALLENRADIAVHSMKDVP 86 + + M T GD L +PL +GG+G ++ KELEVAL+ D VHS+KDVP Sbjct: 149 KDVRPVDFPVRTMATLGDQNLKSPLYVIGGEGRAIWTKELEVALMAGGVDAIVHSLKDVP 208 Query: 87 VEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALPAGSIVGTSSLRRQCQLAERRPDL 143 P G+ L I EREDPRDA V Y SL +P GS++GTSS+RR L P L Sbjct: 209 TTMPDGVELAAILEREDPRDALVVKENLPYKSLQEMPQGSVIGTSSVRRVSLLRRAYPHL 268 Query: 144 IIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAV 201 + +RGN+ TRL+KLD +G Y A++LA AGLKR+ LE RI A + + L AVGQG++ Sbjct: 269 MFSDVRGNINTRLAKLDAADGPYTALVLAAAGLKRMDLEHRITAYVSEPVMLHAVGQGSL 328 Query: 202 GIECR-------LDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAE--- 251 IE R D R R ++ ++++ R AERA+ R+EGGC +P+G Sbjct: 329 AIEVRTPRGESAERDERIRRMIRSISNWRATWRCVAERALMHRMEGGCSIPLGVSTRFED 388 Query: 252 -----------------------------------LIDGEIWLRALVGAPDGSQIIRGER 276 + + A++ + DG+++ + Sbjct: 389 HADIEGLLNERNETPSEMASAGISRPDIRIAHEPPPQGSFLTMAAVIVSLDGTRMCKHSH 448 Query: 277 R---GAPQDAEQMGISLAEELL-NNGAREILAEV 306 + +DAEQ+GI +AEEL + AR ILAEV Sbjct: 449 TQLCRSEKDAEQLGILVAEELEHHQNARAILAEV 482 >UniRef50_Q0ATQ1 Porphobilinogen deaminase n=3 Tax=Alphaproteobacteria RepID=Q0ATQ1_MARMM Length = 321 Score = 307 bits (787), Expect = 3e-82, Method: Composition-based stats. Identities = 129/305 (42%), Positives = 165/305 (54%), Gaps = 14/305 (4%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASH------PGLVVELVPMVTRGDVILDTPLAKV 56 L IATR+SPLAL QA V+ KL A ++ +V+ GD I D L + Sbjct: 5 SRPLAIATRRSPLALVQARDVQAKLAAQCGLSGEDAERCFPILGLVSTGDRIQDRTLIEA 64 Query: 57 GGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS- 115 GGKGLF KE++ A L+ RA AVHSMKDVP P G+ L + EREDPRD ++ + ++ Sbjct: 65 GGKGLFTKEIDEAQLDGRAAFAVHSMKDVPTVLPDGIVLGALLEREDPRDMLIARDGETR 124 Query: 116 LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLK 175 L LP G +GT+SLRRQ QL +RPDL + LRGNV TRL KL +G A LA AGL Sbjct: 125 LADLPEGVTIGTASLRRQAQLLHKRPDLHVVPLRGNVDTRLGKLADGGIHATFLARAGLN 184 Query: 176 RLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235 RLG +R L + LPA QGAVG+ R D +A L+H +T L V AERA Sbjct: 185 RLGRAEALRDPLEADEMLPAAAQGAVGVAIRDGDEEAASYVAGLHHRDTELAVLAERAFL 244 Query: 236 TRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-----GAPQDAEQMGISL 290 L+G C+ PI ++ + + V PDG Q R + R P A Q G L Sbjct: 245 FELDGSCRTPIAAH--VNKVSMDFIGEVLTPDGQQSWRRQIRFDMTHATPDSARQAGQDL 302 Query: 291 AEELL 295 + Sbjct: 303 GRAVR 307 >UniRef50_Q6L2G8 Probable porphobilinogen deaminase n=1 Tax=Picrophilus torridus RepID=HEM3_PICTO Length = 282 Score = 306 bits (785), Expect = 6e-82, Method: Composition-based stats. Identities = 107/267 (40%), Positives = 154/267 (57%), Gaps = 8/267 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LA+ QA VKD+L + G+ E+ ++GD+ LD+PL +GG G+FV + Sbjct: 3 IRIGTRSSKLAMIQAMMVKDRLDSL--GIETEVKGFTSKGDINLDSPLYSIGGTGVFVDD 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L +L+N DIAVHS KD+P L + + +R+DPRD +S + SL+ L A S++ Sbjct: 61 LNRMILKNEIDIAVHSAKDIPSFIDDSLEISAVLKRDDPRDVLISQH--SLNDLEASSVI 118 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR +L R D++I+ LRGN+ TRL KLDNG+YD II+A A R+ +R Sbjct: 119 GTSSLRRIKELKTLRNDILIKDLRGNIDTRLKKLDNGDYDGIIMAKAAYDRM-RINRRHF 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L + +PA QG + I DS ++L +N ET + AER + + L GC P Sbjct: 178 ILNYDDFVPAPNQGIIAI-ISKKDSEINDVLKKINDDETYNDMKAERLILSGLNLGCSKP 236 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQII 272 +G YA I++R D + I Sbjct: 237 VGIYAH--KNRIFMRFYSLKNDDYKDI 261 >UniRef50_A2SQU4 Uroporphyrin-III C-methyltransferase n=11 Tax=Euryarchaeota RepID=A2SQU4_METLZ Length = 542 Score = 306 bits (785), Expect = 6e-82, Method: Composition-based stats. Identities = 119/308 (38%), Positives = 165/308 (53%), Gaps = 22/308 (7%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 + +RI TR S LAL Q V L + G+ E V + T GD + D L ++GG G+FV Sbjct: 2 SKIRIGTRGSKLALAQTKKVIGLLAEN--GIDAEYVIIKTTGDKVTDRGLHQIGGFGMFV 59 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 +EL+ A+L D AVHSMKD+P E P+GL V + +R+ P D V N ++ L Sbjct: 60 RELDNAILRGEIDCAVHSMKDIPAERPKGLLTVAVLKRDPPYDFLVMNG--KVEDL---M 114 Query: 124 IVGTSSLRRQCQLAERR---PDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 ++GTSSLRR+ QL P + + LRGN+ TRL KLD+G YD I++A AGL RL + Sbjct: 115 VIGTSSLRRKAQLLRYFHNCPAVRVEMLRGNLDTRLGKLDDGLYDGIMVAEAGLMRLDYK 174 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R L P++ +PA QG + I R D R A LN ++AL ER + ++ G Sbjct: 175 -RNGVRLSPDMFVPAANQGTIAIVSR-DTPELRAAFAPLNDPQSALDCAIERIVMEQVGG 232 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-GAPQDAEQMGISLAEELLNNGA 299 GC P+G + E L A V + DG++ R G + A GI L N GA Sbjct: 233 GCFTPMGIFCE----NQHLTAEVLSLDGTRAERITAEIGDLEGARVAGI----RLKNVGA 284 Query: 300 REILAEVY 307 E++AE Sbjct: 285 -ELIAEAK 291 >UniRef50_Q5KKQ0 Hydroxymethylbilane synthase, putative n=2 Tax=Filobasidiella neoformans RepID=Q5KKQ0_CRYNE Length = 481 Score = 305 bits (781), Expect = 2e-81, Method: Composition-based stats. Identities = 106/289 (36%), Positives = 142/289 (49%), Gaps = 37/289 (12%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPG-------------------------LVVE 37 N + TR+S LAL Q +V D L H G Sbjct: 30 TNTFILGTRKSNLALVQTGHVADDLRRLHSGAGSKFGETREEGDDAEQGDVPFVHPYTFS 89 Query: 38 LVPMVTRGDVILDTPLAKV-------GGKGLFVKELEVALLENRADIAVHSMKDVPVEFP 90 + M T GD TPL + K L+ ELE L+ D+ VHS+KDVP Sbjct: 90 IESMTTVGDRNQTTPLHLLSPYSSTQPAKSLWTDELEARLINGHFDMLVHSLKDVPTVLK 149 Query: 91 QGLGLVTICEREDPRDAFVSN---NYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRS 147 G + + +R DPRDA V Y L+ LP G++VGT S+RR QL P+L+ Sbjct: 150 DGCEIGCMAKRHDPRDALVVKQGLPYKRLEDLPDGAVVGTGSVRRVAQLKRAFPNLVFED 209 Query: 148 LRGNVGTRLSKLDNGE--YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIEC 205 +RGN+ TR +KLDN + + A+ILA++GL+RLG+ R + L + AVGQGA+ IE Sbjct: 210 MRGNLNTRFNKLDNPQSPFSALILAMSGLERLGMAHRATSPLSSPTLMHAVGQGALAIEI 269 Query: 206 RLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID 254 R D R R L L H +T AER LEGGC VP+G +EL++ Sbjct: 270 RSTDPRVRNCLRGLGHWQTEWSCGAERGCLRVLEGGCSVPVGVESELVE 318 Score = 45.8 bits (108), Expect = 0.002, Method: Composition-based stats. Identities = 17/57 (29%), Positives = 26/57 (45%), Gaps = 4/57 (7%) Query: 256 EIWLRALVGAPDGSQIIRGE----RRGAPQDAEQMGISLAEELLNNGAREILAEVYN 308 ++ L + V + DGS+ + + + AEQ G A L GA EIL E+ Sbjct: 386 KLTLHSCVTSTDGSKHVLFTPPPVLVRSYRQAEQFGEECARRLRGMGAGEILDEINK 442 >UniRef50_D1B7N1 Porphobilinogen deaminase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B7N1_THEAS Length = 307 Score = 304 bits (780), Expect = 2e-81, Method: Composition-based stats. Identities = 114/299 (38%), Positives = 159/299 (53%), Gaps = 12/299 (4%) Query: 10 TRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVA 69 TR SPLA+ QA KD++ + G V L+ + T GD LA GG G FVK LE Sbjct: 8 TRSSPLAMAQARMWKDRIESL--GHSVRLLDVSTHGDRDRRRHLACFGGFGAFVKALEDR 65 Query: 70 LLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSS 129 LL + AVHS+KDVP P GL + + ER D V+ SL+ LP+G+++GTSS Sbjct: 66 LLSGQGHGAVHSLKDVPSVQPDGLVIAGVLERGPRGDVLVTREGLSLEELPSGAVIGTSS 125 Query: 130 LRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPP 189 +RR Q+ R DL + RGNV +RL KL+ G + I+LA AGL+RLG IRA + Sbjct: 126 IRRAAQVRMLRGDLNVECCRGNVHSRLRKLEQGLFHGIVLARAGLERLG----IRAPMAE 181 Query: 190 EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSY 249 + + GQGAV +E R S L A L H T L V AER+ GC P+ + Sbjct: 182 LPFITSPGQGAVALEAREG-SELHLLGARLTHRSTWLEVLAERSFLKAFGMGCSAPVAAS 240 Query: 250 AELIDGEIWLRALVGAPDGSQIIRGERRGAP---QDAEQMGISLAEELLNNGAREILAE 305 A + + L+ V +P+G+ E P +DA +G + E+ +G+ E+L+ Sbjct: 241 AVMDRDTLTLKVQVLSPNGTSAAEAEVSCVPWGEEDAYALGEAAFREI--SGSPEVLSA 297 >UniRef50_C6V4N6 Porphobilinogen deaminase n=2 Tax=Neorickettsia RepID=C6V4N6_NEORI Length = 286 Score = 303 bits (778), Expect = 4e-81, Method: Composition-based stats. Identities = 112/292 (38%), Positives = 162/292 (55%), Gaps = 9/292 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L++ R S LAL QA V+ L + LV + T GD++ D PL +VGGK LF+KE Sbjct: 4 LKVGARCSTLALAQARLVERALAPYCERID--LVGVRTSGDILSDIPLTEVGGKALFLKE 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE LL DIAVHSMKDVP + L +V + +R P D FVS Y ++ +LP+G+++ Sbjct: 62 LEEKLLTGEIDIAVHSMKDVPAFYHDDLEVVPVLKRAIPNDVFVSFRYPNMLSLPSGAVI 121 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT + RR QL +R + LRGN+ TR+ K D IILA GL+RLGL I Sbjct: 122 GTCAPRRVVQLNQRF---RVIPLRGNIATRVEK--AKNLDGIILAFCGLERLGLCKMISE 176 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 + ++ LP V QGA+ +E R D REL+ ++ ET + TAERA + G C+ Sbjct: 177 VIHEDVMLPGVAQGALCVEFRKKDHFLRELILNISDRETIICTTAERAFLEEINGDCKTA 236 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 +G+ A + + ++ ++G + R G+ +A+Q+G S A LL Sbjct: 237 LGALAVVKNNTLYFTGMLGKDNRPCYFRTS--GSCLNAKQIGRSAALALLRM 286 >UniRef50_Q1AUK3 Porphobilinogen deaminase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=HEM3_RUBXD Length = 305 Score = 302 bits (775), Expect = 8e-81, Method: Composition-based stats. Identities = 133/306 (43%), Positives = 174/306 (56%), Gaps = 5/306 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + L + TR SPLAL QA L A+ G VEL + T D D PL+ + + + Sbjct: 1 MAGRLVLGTRGSPLALAQAEACAAGLRAA--GFAVELRRIRTTSDRRPDDPLSVIDQRDV 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F ++L+ ALL D+AVHSMKDVP E P+G+ L + R DP DA VS +D LP Sbjct: 59 FTRQLDEALLAGEVDLAVHSMKDVPTEVPEGIVLAAVAGRADPSDALVSEGGWGVDGLPE 118 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ V TSSLRR+ QL RRPDL + +RGNV TR+ K+ G +A++LA AGL RLGL Sbjct: 119 GARVATSSLRRRAQLLHRRPDLRVVEIRGNVDTRIRKMRAGAAEAVVLARAGLVRLGL-E 177 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 A +P ++ LPAVGQGA+ + R D R E+ ALN V AERA+ LEGG Sbjct: 178 VPHAVIPHDVLLPAVGQGALAVAVRRGDPRLEEIRRALNDPAAEREVAAERALLRALEGG 237 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 C+VP+G+ A + LR +V +PDG+ + GE RG + LA LL GA Sbjct: 238 CRVPVGARAVAGGRGVLLRGVVVSPDGAALCGGEERGEEPEEVG--RRLAARLLERGAAG 295 Query: 302 ILAEVY 307 IL V Sbjct: 296 ILGFVR 301 >UniRef50_B5GJG2 Porphobilinogen deaminase n=3 Tax=Streptomyces RepID=B5GJG2_9ACTO Length = 335 Score = 302 bits (774), Expect = 1e-80, Method: Composition-based stats. Identities = 113/309 (36%), Positives = 153/309 (49%), Gaps = 12/309 (3%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTP----LAKVGGK 59 + + +R S LA Q + ++ PG+ + GD TP + + G Sbjct: 31 RTVTVGSRGSALARAQVREMVERWEREVPGVRFVRRVITEAGDADRSTPTVAGVTRRAGV 90 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTIC-EREDPRDAFVSNNYDSLDA 118 F E AL+ D+ VH +KD+P G L+ RED RDA +L Sbjct: 91 SAFSSRQEAALVRREVDVVVHCLKDLPTTPAPGTALLRTPGPREDARDALC---GATLAG 147 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 LP G+ VGT S RR QL RPDL + +RGNV RL++L DA++LA AGL RLG Sbjct: 148 LPRGARVGTGSTRRVAQLLALRPDLEVIPVRGNVPARLARLRT--LDAVVLAAAGLHRLG 205 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 L I L PE PA GQGA+ I+ R S LLAA T V AER + L Sbjct: 206 LTEEITEYLDPEAYPPAPGQGALAIQVREG-SGAARLLAASGDPATDTEVRAERVLLAEL 264 Query: 239 EGGCQVPIGSY-AELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 GGC VP+G++ + G + L A V APDG + I +G + +++ +++AE LL Sbjct: 265 HGGCSVPLGTWTSRPSPGTLRLHAAVTAPDGGRQITATAQGPASEPDKLALTVAERLLAG 324 Query: 298 GAREILAEV 306 GA ILAE Sbjct: 325 GAARILAEA 333 >UniRef50_A4YD92 Probable porphobilinogen deaminase n=1 Tax=Metallosphaera sedula DSM 5348 RepID=HEM3_METS5 Length = 290 Score = 301 bits (772), Expect = 2e-80, Method: Composition-based stats. Identities = 110/297 (37%), Positives = 153/297 (51%), Gaps = 14/297 (4%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +RIA R S L+L Q V L A G E + + T+ D+ + PL ++G KG+F K Sbjct: 2 KIRIAARGSKLSLKQVEIVTTYLQAK--GYETEFIEIKTKADLFGNKPLHEIG-KGVFEK 58 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E+ A+L+ RADIAVHSMKD+ E P GL L+ +RE+P D VS +L+ LP S Sbjct: 59 EVNEAVLQGRADIAVHSMKDMSSELPPGLELLATPKRENPVDVLVSE--LNLEELPEKSR 116 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GT SLRR L RPDL++ ++RGNV TRL K + EYD IILA AGL+RLG+E + R Sbjct: 117 IGTGSLRRANFLKVVRPDLVVENIRGNVDTRLRKYRDHEYDGIILAEAGLRRLGVEVK-R 175 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L E P QG + + + L LN T AE+ + GGC Sbjct: 176 FPLDVESFTPEPNQGIIAVV---GSPKFLGLFQELNDTGTMKEALAEKETVKVVGGGCHS 232 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRG---ERRGAPQDAEQMGISLAEELLNNG 298 P+G L D L + +G + + R Q+G +L + + + G Sbjct: 233 PLGVLFRLEDDV--LHGIASYSNGVKRVTVKLSTRESPQIAGNQLGKALVKAMKDEG 287 >UniRef50_C7R376 Porphobilinogen deaminase n=1 Tax=Jonesia denitrificans DSM 20603 RepID=C7R376_JONDD Length = 344 Score = 301 bits (771), Expect = 3e-80, Method: Composition-based stats. Identities = 126/344 (36%), Positives = 172/344 (50%), Gaps = 47/344 (13%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LR+ TR S LA Q+ L+A G+ V+L + T GD +L LA +GG G+FV Sbjct: 4 LRLGTRASALATAQSRATA-ALIAQATGVTVDLTHIRTDGD-VLTGSLATMGGAGVFVTA 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 + ALL DIAVHS+KD+P +G ++ + ERE+P+DA S + +SL LP G++V Sbjct: 62 IRQALLAGDIDIAVHSLKDLPTTPHEGTTII-VPERENPQDALCSRHGESLAHLPHGALV 120 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD---------NGEYDAIILAVAGLKR 176 GT S RR QL RPDL I +RGNV TRL+++ + DA++LA AGL+R Sbjct: 121 GTGSPRRAAQLLVARPDLRIVDIRGNVDTRLARVGLSTADKPHIRNDLDAVVLAAAGLRR 180 Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSR----TRELLAALNHHETALRVTAER 232 LG I LPP LPA GQGA+ IE R D + + L+H TA V AER Sbjct: 181 LGRAHVISELLPPTSMLPAPGQGALAIEVRHDMADHHPSILAGIRTLHHQPTAYAVAAER 240 Query: 233 AMNTRLEGGCQVPIGSYAEL-----------IDGEIWLRALVGAPDGSQII--------- 272 A+ LE GC P+G+ A + +D + A P + I Sbjct: 241 AVLRHLEAGCAAPVGALATMHNTTLTLTATALDPRLTPTAHTPTPSTTTDINAAPTPMTA 300 Query: 273 -----------RGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 + DA + GI+LA LL +GA E L + Sbjct: 301 PADARPPIRLTHTHTVTSENDATEAGITLATTLLTHGAAEFLRD 344 >UniRef50_C7M2H5 Porphobilinogen deaminase n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7M2H5_ACIFD Length = 291 Score = 300 bits (768), Expect = 6e-80, Method: Composition-based stats. Identities = 123/299 (41%), Positives = 171/299 (57%), Gaps = 14/299 (4%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +RIATR+S LA WQA V ++L ELV + T GD + LA++GG+G+FVK Sbjct: 3 PVRIATRRSALARWQASLVGERLGR------YELVEVHTAGDRDQASSLAEIGGQGVFVK 56 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E++ A++ ADIAVHS KD+P L L + ER D RDA V L+ L G+ Sbjct: 57 EVQAAVVRGEADIAVHSAKDLPTAAGP-LLLAAVLERADARDAIV---GARLEELAIGAR 112 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGTS+ RR QL RPDL + S+RGN+ TRL ++ GE DAI++AVA L+RLGLE Sbjct: 113 VGTSAPRRAAQLRLLRPDLEVVSIRGNIATRLGRV--GELDAIVMAVAALERLGLEEPPW 170 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 LP E+ P GQGA+ +EC D E L +L+ + + AERA+ GC + Sbjct: 171 WPLPEEVLCPQAGQGAIAVECAPDADGLIERLRSLDDDRSRREIEAERAVLAAFGTGCAL 230 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 P+G+ A + LRA+ PDG++ + ER G D +G ++AE L GA ++ Sbjct: 231 PLGARAHADGSSLRLRAVAVDPDGTRQLEVEREGV--DPATLGATVAEVLRRLGADALV 287 >UniRef50_D1JID7 Porphobilinogen deaminase n=1 Tax=uncultured archaeon RepID=D1JID7_9ARCH Length = 290 Score = 299 bits (767), Expect = 7e-80, Method: Composition-based stats. Identities = 97/295 (32%), Positives = 154/295 (52%), Gaps = 11/295 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 + + TR S LAL Q V ++L G+ E+ + + GDV+ D L ++ G+FVK+ Sbjct: 1 MIVGTRGSNLALVQTKKVCERLSEL--GVECEIKTVQSLGDVMTDRGLYEMPTIGVFVKK 58 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L++ LL+ + DIAVHSMKD+P E + L + R+ P DA VS LD +P G+++ Sbjct: 59 LDMMLLDAKIDIAVHSMKDMPSEREEELDTSAVLPRDSPYDALVSR--YRLDDMPEGAVI 116 Query: 126 GTSSLRRQCQLAERRPD----LIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 GTSS+RR+ Q + + I+ +RGNV TR++K GEYD++ILA AG +RL L+ Sbjct: 117 GTSSVRRRYQFLNYVGERGVKVTIKDIRGNVDTRIAKFRRGEYDSVILAEAGFERLKLDI 176 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 L + +P+ QG + + R E+L ++ ET + E + + GG Sbjct: 177 EY-ERLDRDPFVPSPRQGIIAVVARRGSKE-SEILKQIDDSETRIEAEVEEEVLKVIGGG 234 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 C +P+G +A G + L V A D + G E+ LA++ + Sbjct: 235 CSLPVGVHATAKGGSVELAVYVAASDVRYKLEKVVLGKDYYMEET-RELAQKFKS 288 >UniRef50_C7DH16 Porphobilinogen deaminase n=1 Tax=Candidatus Micrarchaeum acidiphilum ARMAN-2 RepID=C7DH16_9EURY Length = 301 Score = 299 bits (766), Expect = 9e-80, Method: Composition-based stats. Identities = 108/306 (35%), Positives = 169/306 (55%), Gaps = 7/306 (2%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M ++ + I TR S LA+ QA V++KL A P + +V + T + + D A+ K Sbjct: 1 MSESEITIGTRGSELAVAQAEIVRNKLAAIEPRISFRIVKIKTLNEKV-DRSKART-EKD 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 ++ KE++ A+LE R DIAVHS+KD+ + + + + +R+DPRD F+ N + L Sbjct: 59 IYTKEIDEAILERRIDIAVHSLKDLKFNMDENMQIGAVPDRDDPRDVFIGNTETEFEHLG 118 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 ++VGTSS+RR+ QL P +I L GN+ TRLSKL++GE+ I++A AG+KRLG Sbjct: 119 TDALVGTSSIRRRVQLTRINPKPMISDLHGNIDTRLSKLNSGEFSGIVIAAAGVKRLGKA 178 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R+ +PA+GQGA+ + D+S ELL +++ + + V E Sbjct: 179 VRM-QYFDERDVVPAIGQGAIAVTVHKDNSAAAELLKRIDNMKARVEVGEEIEFGKAFGT 237 Query: 241 GCQVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GC +PIG+ A+ L G+I + V G +++GE P A G SLAE L+ GA Sbjct: 238 GCNLPIGANAKMLESGKIGIVGFVSDLAGKTLVKGETETGPGHA---GKSLAELLIKKGA 294 Query: 300 REILAE 305 ++ Sbjct: 295 GNLIER 300 >UniRef50_A9HK97 Porphobilinogen deaminase n=12 Tax=Acetobacteraceae RepID=A9HK97_GLUDA Length = 367 Score = 297 bits (762), Expect = 3e-79, Method: Composition-based stats. Identities = 132/312 (42%), Positives = 166/312 (53%), Gaps = 21/312 (6%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLV----VELVPMVTRGDVILDTPLAKVGGKG 60 LR+ TR SPLAL Q L P L + + T GD + + LA++GGKG Sbjct: 46 PLRVGTRASPLALVQTRAFLTMLTRFCPVLRDMGAFQEHQINTTGDQVQNRRLAEIGGKG 105 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD------ 114 LF KE+ AL + R D AVHS+KD+ P GL L RED RDA + Sbjct: 106 LFAKEIHDALSDGRIDFAVHSLKDLETTLPPGLVLACTLRREDARDALILGPGAGGRHDA 165 Query: 115 -----SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIIL 169 ALP ++VG +S+RRQ Q+ RPDL LRGNV TRL KL + DA +L Sbjct: 166 ADAADPYAALPRNALVGCASVRRQAQMLHVRPDLRFGLLRGNVQTRLDKLAARQCDATLL 225 Query: 170 AVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVT 229 A+AGL+RLG+E R L PEI +PA GQG VG+ R D RELLAA+ +E T Sbjct: 226 ALAGLRRLGMEDRADIVLDPEIMVPAAGQGIVGVTVRESDVELRELLAAIEDYEARAVAT 285 Query: 230 AERAMNTRLEGGCQVPIGSYAELIDG------EIWLRALVGAPDGSQIIRGERRGAPQDA 283 AERA+ L+G C+ PIG YA L+ G + L LV DGS ++R G DA Sbjct: 286 AERALLAELDGSCRTPIGGYARLVPGLAGAEASLRLTGLVAREDGSFLLRRTVTGLRADA 345 Query: 284 EQMGISLAEELL 295 E+MG L L Sbjct: 346 EEMGRELGRSLR 357 >UniRef50_C4JRY9 Porphobilinogen deaminase n=1 Tax=Uncinocarpus reesii 1704 RepID=C4JRY9_UNCRE Length = 287 Score = 296 bits (759), Expect = 6e-79, Method: Composition-based stats. Identities = 107/324 (33%), Positives = 155/324 (47%), Gaps = 58/324 (17%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 I TR+SPLAL Q V+ L ++P Sbjct: 7 KTYTIGTRKSPLALVQTDLVRRALQTAYPN------------------------------ 36 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD---SLDALP 120 D+ VH VP + P L + RE+PRD V +L LP Sbjct: 37 -----------CDLKVHG--HVPTQIPDACVLGAMMPRENPRDVLVIKKGLPWMTLAELP 83 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLKRLG 178 AGS+VGTSS+RR QLA P L+++ +RGN+ TRL+KLD +G + +I+A AGL R G Sbjct: 84 AGSVVGTSSVRRTAQLARHYPHLVVQDIRGNIDTRLAKLDAEDGPFTCLIMAAAGLLRTG 143 Query: 179 LESRIRAALPPE--ISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236 E+R+ L + L AVGQGA+GIE R DD ++++ + T AER + Sbjct: 144 HENRVTQYLDSKNGKMLHAVGQGALGIEVRTDDEVMKDMVNKIGDMPTTYACMAERNLLR 203 Query: 237 RLEGGCQVPIGSYAELIDGE-----IWLRALVGAPDGSQIIRGERRG---APQDAEQMGI 288 +EGGC P+G E I + + LRA+V + DG + + E+ G + ++AE G Sbjct: 204 TVEGGCSAPLGVETEWIQDDNGKSLLRLRAIVVSVDGKEAVELEKDGDVESIEEAEAFGK 263 Query: 289 SLAEELLNNGAREILAEVYNGDAP 312 +A EL++ GA +IL E+ Sbjct: 264 QVALELIDKGAGKILEEIQRQKRQ 287 >UniRef50_B5JN62 Porphobilinogen deaminase n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JN62_9BACT Length = 291 Score = 295 bits (756), Expect = 1e-78, Method: Composition-based stats. Identities = 112/294 (38%), Positives = 143/294 (48%), Gaps = 16/294 (5%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 IATR+SPLA+ Q H K+ P V + MVT GD + L K GGKGLF Sbjct: 6 REYVIATRKSPLAMAQTHLAKELFQRGMPDAVFRIEKMVTTGDKRQEWSLEKQGGKGLFT 65 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE ALLE RAD AVHS KD+P E P+GL L R+ D + + L Sbjct: 66 KELEDALLEGRADFAVHSAKDLPSEMPKGLALAGFLPRQTCEDVLILRDGVESPKL---- 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG---LE 180 + T S RR+ QL P +RGNV TRL+K+ G+ DA +LA AGL RLG E Sbjct: 122 -IATGSPRRRIQLRYLFPKAEFTEIRGNVDTRLTKIARGDADATVLASAGLNRLGIESWE 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 L + +PAVGQ AV I+CR +D T A ETA+ V ER+ L G Sbjct: 181 GVTFRKLTLDECVPAVGQAAVAIQCREEDVDT---FRAHLDEETAIAVNLERSFLEELGG 237 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 GCQV + G + + G ++ + EQ+ L E+L Sbjct: 238 GCQVAFAV--NYVGGRLRI---YHKQCGKEVRDLPQEYVATHYEQIAAKLIEQL 286 >UniRef50_C3MZR8 Probable porphobilinogen deaminase n=11 Tax=Sulfolobus RepID=HEM3_SULIA Length = 293 Score = 295 bits (755), Expect = 2e-78, Method: Composition-based stats. Identities = 98/293 (33%), Positives = 147/293 (50%), Gaps = 9/293 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +RIA R S L+ Q + +KL G+ E++ + T+ D+ PL+K+G KG+F K Sbjct: 2 KIRIAARGSKLSRIQVDMLGEKLKKI--GIEYEIIDIKTKADLFSTEPLSKLG-KGVFEK 58 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E+ A+LE +ADIAVHSMKD+ E L + + ER+ P D ++ +LD L + Sbjct: 59 EVNEAVLEGKADIAVHSMKDILSEINPSLEIFAVLERDPPYDILIAEK--NLDKLDSNIT 116 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSS+RR+ L +P++ + +RGNV TR+ K + EY +ILA A LKRL + Sbjct: 117 IGTSSIRRKNFLKYIKPEINTKDIRGNVDTRIRKYLSKEYQGLILAEASLKRLNMTMNYH 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L P QG + R D + +E+ +NH +T AERA+ + + GGC Sbjct: 177 R-LNVYDFTPEANQGIIVALGRKKDEKIKEIFKEINHKDTLDEALAERAVISLVGGGCHS 235 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 PIG + E + DG + I P D +G L L Sbjct: 236 PIGVLFKKEGKE--FYGIASYSDGKKKITVSIS-KPGDPYTIGSELGLLLKKE 285 >UniRef50_D2RNT2 Porphobilinogen deaminase n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RNT2_ACIFE Length = 288 Score = 293 bits (751), Expect = 6e-78, Method: Composition-based stats. Identities = 117/297 (39%), Positives = 163/297 (54%), Gaps = 14/297 (4%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L +ATR S LAL Q H V L + G+ E+ + T GD L K+GG+G+FV Sbjct: 2 KKLIVATRGSRLALAQTHIVCRLLEEA--GVETEIRTITTAGDRDRIHALVKIGGRGIFV 59 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 +E+E LL ADIAVHS KD+P + GL + + DPRDA V L+ AGS Sbjct: 60 REIERELLSGEADIAVHSAKDLPYQLASGLVIAGTPSQADPRDALVLLKERKLE---AGS 116 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +VGT S RR +++ P+L+ R +RGNV TRL KL+ GEYDAI+LA+AG++RL L+ Sbjct: 117 VVGTGSPRRIREISRVLPELVFRDIRGNVTTRLHKLERGEYDAIVLAMAGIQRLALDMEQ 176 Query: 184 RAA--LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 L E +PA QG +G+ECR D LL ++ ET R ER + T ++ Sbjct: 177 FQIRPLSTEQVIPAGCQGIIGVECRQKDRELVRLLQQISDPETWRRFQWERQLFTSMKVD 236 Query: 242 CQVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 C P+G + L G + L A+V DG + R G ++ + + SL EEL + Sbjct: 237 CSRPVGIHCRLLKSGRMELLAMV---DGKRARRL---GMEKEGKALCASLKEELYDR 287 >UniRef50_C0W553 Porphobilinogen deaminase n=2 Tax=Actinomycetales RepID=C0W553_9ACTO Length = 402 Score = 293 bits (750), Expect = 6e-78, Method: Composition-based stats. Identities = 126/385 (32%), Positives = 173/385 (44%), Gaps = 77/385 (20%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASH----PGLVVELVPMVTRGDVILDTPLAKVGGK 59 + +R+ TR S LAL Q+ V L + L VELVP+ TRGDV T L+++GG Sbjct: 2 STVRLGTRGSALALTQSGLVARMLEQAAALAGQELHVELVPVRTRGDVD-PTALSQLGGV 60 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD-SLDA 118 G+F L ALL D+AVHS KD+P GL + + REDPRD + L Sbjct: 61 GVFATALREALLAGECDLAVHSYKDLPTAAVPGLRIAAVPAREDPRDVLCTRAATLGLHD 120 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--------------DNGEY 164 LPAG+ VGT S RR QL +RPDL I +RGNV TRL+++ + Sbjct: 121 LPAGARVGTGSPRRSAQLLAQRPDLTIVPIRGNVPTRLARVVGSVVSADGPMGATAEPDL 180 Query: 165 DAIILAVAGLKRLGLESRIRAALP---------------------------PEISLPAVG 197 DA ILA++G++RLGLE L LPA Sbjct: 181 DAAILALSGMRRLGLEDYASQPLAARCGARSQVEVQGIPDGGSAAGSPATTEPWMLPAAA 240 Query: 198 QGAVGIECRL----DDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELI 253 QGA+ +E R + LA ++ T AER++ L GC P+G+ A + Sbjct: 241 QGALAVETRDRVSCELPVLTVALALVDDPVTRACADAERSLMRCLAAGCAAPVGALARPL 300 Query: 254 D--------------------------GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMG 287 D I L ALV + DG+Q+ R G ++AE +G Sbjct: 301 DVAGEPAAGRDLPTEPGTALEPGPDQAPAICLEALVASLDGTQLRRASATGTLEEAEDLG 360 Query: 288 ISLAEELLNNGAREILAEVYNGDAP 312 +AE LL +GA +I + +P Sbjct: 361 RCVAERLLADGAAQITDLQASKGSP 385 >UniRef50_Q4PFH9 Putative uncharacterized protein n=1 Tax=Ustilago maydis RepID=Q4PFH9_USTMA Length = 770 Score = 293 bits (750), Expect = 7e-78, Method: Composition-based stats. Identities = 116/296 (39%), Positives = 154/296 (52%), Gaps = 39/296 (13%) Query: 34 LVVELVPMVTRGDVILDTPLAKVGGKG--LFVKELEVALLENRADIAVHSMKDVPVEFPQ 91 + M T GD L +PL +GG+G ++ KELEVAL + D VH +KDVP PQ Sbjct: 249 HAFPITSMSTAGDQNLRSPLYVIGGEGKAIWTKELEVALEQGAVDAIVHCLKDVPTALPQ 308 Query: 92 GLGLVTICEREDPRDAFVSN---NYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSL 148 GL L + EREDPRDA V Y LD LP GS++GTSS+RR QL R P L+ + Sbjct: 309 GLELAAVLEREDPRDALVVKAGLPYKVLDELPVGSVIGTSSVRRVAQLRRRYPHLVFSDV 368 Query: 149 RGNVGTRLSKLD--NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECR 206 RGN+ TRL+KLD NG Y A+ILA AGL RL + +RI A L + L +VGQG++ IE R Sbjct: 369 RGNINTRLAKLDAPNGPYTALILAAAGLVRLNMHARITAFLSSPVLLHSVGQGSLAIEVR 428 Query: 207 L----------DDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGE 256 D+R REL+ ++ R AER++ LEGGC +P+G D Sbjct: 429 TPPEGADPTTNRDARIRELIRSIGDWRATFRAEAERSLLKELEGGCSIPVGVETRFDD-- 486 Query: 257 IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYNGDAP 312 + G +A I+L ++ + G AE+ NG P Sbjct: 487 ----------------HDQVEGQRSEA----IALVDDFVTQGNAGAKAELPNGGMP 522 Score = 45.8 bits (108), Expect = 0.002, Method: Composition-based stats. Identities = 28/89 (31%), Positives = 39/89 (43%), Gaps = 8/89 (8%) Query: 222 HETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR---G 278 T + AER ++T + S + L A+V + DGSQ R Sbjct: 573 PSTNAQTIAERIVSTSY----SIVDRSTPAPEGRTLHLDAIVVSLDGSQESRYSASKHCT 628 Query: 279 APQDAEQMGISLAEELL-NNGAREILAEV 306 +DA ++GI +A EL GAR IL EV Sbjct: 629 TVKDARELGIHVAHELAHKKGARAILEEV 657 >UniRef50_Q2FTK7 Hydroxymethylbilane synthase n=3 Tax=Methanomicrobiales RepID=Q2FTK7_METHJ Length = 295 Score = 292 bits (748), Expect = 1e-77, Method: Composition-based stats. Identities = 111/306 (36%), Positives = 163/306 (53%), Gaps = 19/306 (6%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LR+ TR S LA QA V L G+ ELV + T GD PL ++GG+G+FV+ Sbjct: 2 PLRVGTRASELAKAQAVKVCTMLEDL--GVDTELVFISTAGDEQTGVPLHEIGGQGVFVR 59 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L+ AL++N+ D+AVHSMKD+P E P GL I R+ P D V+++ L + Sbjct: 60 ALDDALVQNKIDLAVHSMKDIPAERPYGLVTSAILARDSPCDYIVTDH-----ELDEITT 114 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSS RR Q P IR LRGNV TRLSKL +GEYDAI+LA AGL+RL + Sbjct: 115 LGTSSTRRTAQCRRNLPWADIRPLRGNVNTRLSKLQSGEYDAIMLAKAGLERLSMTLDGY 174 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L P + +P+ QG + + R D ++++ ++ +T + ER + + GGC Sbjct: 175 Q-LDPRVHVPSPNQGTIAVVSRT-DPDVTDIISKIDDPKTRMDTLLERRVMEMIGGGCFT 232 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGER-RGAPQDAEQMGISLAEELLNNGAREIL 303 P+G Y + + A V + +G + R ER DA++ G+ + E A +++ Sbjct: 233 PLGIYCKDR----LMIAEVLSLEGDRHFRLERLVSDIDDADRFGLEVRER-----AGDLI 283 Query: 304 AEVYNG 309 E Y Sbjct: 284 REAYER 289 >UniRef50_Q8I5V3 Porphobilinogen deaminase n=6 Tax=Plasmodium RepID=Q8I5V3_PLAF7 Length = 435 Score = 291 bits (746), Expect = 2e-77, Method: Composition-based stats. Identities = 95/370 (25%), Positives = 164/370 (44%), Gaps = 61/370 (16%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHP----GLVVELVPMVTRGDVILD-TPLAKVG 57 + + I TR SPLAL Q+ V+ K+M+ + V + T GD ILD + G Sbjct: 59 KDEIIIGTRDSPLALKQSEKVRKKIMSYFKKMNKNINVTFKYIKTTGDNILDSKSVGLYG 118 Query: 58 GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD 117 GKG+F KEL+ L+ D+ VHS+KDVP+ P + L +R+ DAF+S Y S++ Sbjct: 119 GKGIFTKELDEQLINGNVDLCVHSLKDVPILLPNNIELSCFLKRDTINDAFLSIKYKSIN 178 Query: 118 ALPAGS------------------------IVGTSSLRRQCQLAERRPDLIIRSLRGNVG 153 + +GTSSLRR+ Q+ R ++ + ++RGN+ Sbjct: 179 DMNTVKSVSKTEDIHHINKKDSDHNNDTLCTIGTSSLRRRSQIKNRYKNIYVNNIRGNIN 238 Query: 154 TRLSKLDNGEYDAIILAVAGLKRL--------------------------------GLES 181 TR+ KL NGE DA+I+A+ G++RL L Sbjct: 239 TRIEKLYNGEVDALIIAMCGIERLIKKANLKHLLKNKEQKNICQPFLLKCNNKKCIDLCH 298 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 L + PA+GQG + + + LL +N+ ++ + ER+ ++G Sbjct: 299 VNIQKLNKNLIYPALGQGIIAVTSHKKNYFISSLLKNINNKKSEMMAQIERSFLYHIDGN 358 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 C +PIG Y + + +I+L ++ G + ++ + +++G + A ++ E Sbjct: 359 CMMPIGGYTNMRNEDIYLHVIINDIHGYNKYQVTQKDTLYNYKEIGPNAAIKMKEIIGTE 418 Query: 302 ILAEVYNGDA 311 ++ Sbjct: 419 QFNKIKAEAE 428 >UniRef50_A2BFN7 Hydroxymethylbilane synthase (Fragment) n=6 Tax=Coelomata RepID=A2BFN7_DANRE Length = 247 Score = 290 bits (742), Expect = 6e-77, Method: Composition-based stats. Identities = 112/229 (48%), Positives = 144/229 (62%), Gaps = 4/229 (1%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 V+R+ TR+S LA Q V L +P + +E+V M T GD ILDT L+K+G K LF Sbjct: 19 SRVIRMGTRKSQLARIQTDSVAGTLKQLYPDVHLEIVAMSTIGDKILDTALSKIGEKSLF 78 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDAL 119 KELE AL N DI VHS+KD+P P G + I ERE+P DA V + +LD+L Sbjct: 79 TKELENALERNEVDIVVHSLKDLPTSLPPGFTIGAILERENPHDAVVLHPKNAGLTLDSL 138 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLG 178 P S++GTSSLRR QL +R P L ++RGN+ TRL KLD +Y AIILA AGLKR+G Sbjct: 139 PEKSVIGTSSLRRAAQLKKRFPQLEFENIRGNLNTRLKKLDEKDDYAAIILAAAGLKRMG 198 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALR 227 ESRI L PE + AVGQGA+ +E R D E+++ L+H +T LR Sbjct: 199 WESRISQVLGPEDCMYAVGQGALAVEVRAQDKDILEMVSVLHHPDTVLR 247 >UniRef50_Q97B26 Probable porphobilinogen deaminase n=2 Tax=Thermoplasma RepID=HEM3_THEVO Length = 297 Score = 289 bits (741), Expect = 7e-77, Method: Composition-based stats. Identities = 86/267 (32%), Positives = 136/267 (50%), Gaps = 6/267 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 ++I TR S LA+ QA+ V L A G+ E+V + GD+ P+ +G G+FV+ Sbjct: 2 KIKIGTRPSNLAVAQANMVASSLEAI--GIDTEIVKHRSAGDIDTKNPIYSIGKTGVFVQ 59 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 +L +L D+AVHS KD+P E L + +R DA VS L +LP + Sbjct: 60 DLNNMILRGEIDVAVHSAKDIPSEIENRLTIAATLKRGSFNDALVSK--YDLRSLPISAK 117 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGTSS+RR QL R DL ++RGN+ TR++K+ DAI++A A ++RLGL Sbjct: 118 VGTSSIRRIFQLKYARQDLKFENIRGNIETRIAKMSELGLDAIVMAEAAIQRLGLNVEYS 177 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L +PA QG + + + + + R++L +N T + ER++ +L+ GC Sbjct: 178 K-LDENKFVPAPNQGIIAVVSKKEGT-VRKILEEINDENTFEEMQIERSVVQQLKLGCST 235 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQI 271 P+G + + A + G + Sbjct: 236 PVGILSRPSGKGHKIIAQFFSMQGDDV 262 >UniRef50_B0WMK9 Porphobilinogen deaminase n=1 Tax=Culex quinquefasciatus RepID=B0WMK9_CULQU Length = 474 Score = 286 bits (733), Expect = 6e-76, Method: Composition-based stats. Identities = 96/243 (39%), Positives = 133/243 (54%), Gaps = 29/243 (11%) Query: 13 SPLALWQAHYVKDKLMASHPGLVVELV------------------------PMVTRGDVI 48 S LAL Q YV L +P +V E+ M T GD + Sbjct: 167 SKLALIQTKYVISCLQKLNPDVVYEIRKYFQHVHLCWHVPSYLLAFFLSPDTMTTVGDRV 226 Query: 49 LDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAF 108 L+ L K+G K LF K+LE AL D VHS+KD+P P G+ + + ER+DPRDA Sbjct: 227 LNKSLPKIGEKSLFTKDLEDALRTGGVDFVVHSLKDLPTALPLGMAIGAVLERDDPRDAL 286 Query: 109 V---SNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG--E 163 V ++ +L LP GS+VGTSSLRR QLA + ++++ +RGN+ TRL+KLD + Sbjct: 287 VLNEAHRGRTLSTLPKGSVVGTSSLRRSAQLARKYENVVVCDIRGNLNTRLAKLDADGSK 346 Query: 164 YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHE 223 + IILA AGL R+G +R+ + P L AVGQGA+ +ECR +D ++L+ L H E Sbjct: 347 FAGIILAQAGLVRMGWNARVSQVIEPGEILYAVGQGALAVECRSNDEYILDMLSKLCHLE 406 Query: 224 TAL 226 T Sbjct: 407 TQC 409 >UniRef50_C8WDJ7 Porphobilinogen deaminase n=3 Tax=Zymomonas mobilis RepID=C8WDJ7_ZYMMN Length = 308 Score = 285 bits (731), Expect = 1e-75, Method: Composition-based stats. Identities = 116/292 (39%), Positives = 162/292 (55%), Gaps = 7/292 (2%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHP--GLVVELVPMVTRGDVILDTPLAKVGGK 59 + R+ +R SPLAL QA V L A+H V +VP+ T GD LA +GGK Sbjct: 1 MQLPFRLGSRGSPLALIQARSVASALCAAHSWSEDAVVIVPIRTSGDKNRHQALADIGGK 60 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 L+ KEL++AL + D AVHSMKDV P + + + RED D + SL+ L Sbjct: 61 ALWTKELDIALTTGQIDAAVHSMKDVETFRPSHISIAAMLPREDVHDRLIGIP--SLEVL 118 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P VGT+S RR Q+ RPD+ I+ LRGN+ TRL KL N ++DA +LA AGL RLG Sbjct: 119 PYSGCVGTASPRRAAQIRRIRPDIEIKLLRGNIDTRLEKLANKQFDATLLAAAGLIRLGR 178 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 + +P + LPA GQGA+GIE DS E ++ ++H+ T L V +ER + RL Sbjct: 179 ND-VGYDVPLDQMLPAAGQGAIGIEALA-DSAAWEKVSIIDHYPTHLAVQSERQLLLRLN 236 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGA-PQDAEQMGISL 290 C PI +AE+++ I LRA + +G ++ + P DA ++G L Sbjct: 237 ADCHSPIAVFAEILEKNIRLRACLYTENGKFSASIDKEISQPSDAFEVGSLL 288 >UniRef50_C1XV35 Porphobilinogen deaminase n=2 Tax=Meiothermus RepID=C1XV35_9DEIN Length = 304 Score = 284 bits (727), Expect = 3e-75, Method: Composition-based stats. Identities = 114/270 (42%), Positives = 159/270 (58%), Gaps = 11/270 (4%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + +RIATR S LA WQA +V +L G+ LV + T+GD +++ G+G Sbjct: 1 MSR-VRIATRGSRLARWQAEWVAAQLQDQ--GIASTLVIVETQGDRER-VAFSQMQGQGF 56 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA--- 118 F K ++ A+ E RAD+AVHS+KD+P GL L I REDPR+A + Sbjct: 57 FTKAVQDAVREGRADLAVHSLKDLPSAPTPGLVLAAIPIREDPREALLVLPSAWDAQAPA 116 Query: 119 --LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKR 176 L G+ VG+S++RRQ QLA+ RPDL + LRGNV TR+ KL +G Y+AI+LA AGLKR Sbjct: 117 LPLAPGARVGSSAVRRQAQLAQLRPDLKLLELRGNVPTRVEKLQSGGYEAILLAWAGLKR 176 Query: 177 LGLE--SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234 LGL+ L P +PA GQGA+ +ECR +D++ R +L L+ L V ER + Sbjct: 177 LGLDLGGLAVRLLEPREFVPAPGQGALALECREEDTQLRGVLQGLDDPTARLTVGIERGL 236 Query: 235 NTRLEGGCQVPIGSYAELIDGEIWLRALVG 264 RL+GGCQ+ +G+ A+ + G L A G Sbjct: 237 MARLQGGCQLALGASAQRVQGGWQLLAWYG 266 >UniRef50_Q93A65 Porphobilinogen deaminase n=1 Tax=uncultured bacterium RepID=Q93A65_9BACT Length = 299 Score = 283 bits (724), Expect = 6e-75, Method: Composition-based stats. Identities = 120/296 (40%), Positives = 167/296 (56%), Gaps = 19/296 (6%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +R+ATR S LALWQA +V +L G VELV + T+GD P A++ G+G F K Sbjct: 4 VRLATRGSRLALWQAEWVAKQL--VQQGAEVELVVVETQGDR-EKRPFAQMQGQGFFTKA 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN-----NYDSLDALP 120 ++ A+LE RAD AVHS KD+P P GL + + REDPR+ + L Sbjct: 61 VQEAVLEGRADFAVHSYKDLPSARPAGLEIAAVPPREDPRELLLVRLQAVDQVAPGLPLR 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 AG+ VG+S+ RRQ QLA RPDL + LRGNV TR+ KL GEYDA++LA AG++RLGL+ Sbjct: 121 AGARVGSSAARRQAQLAHLRPDLSLLELRGNVLTRVEKLRQGEYDAVLLAYAGVRRLGLD 180 Query: 181 SR--IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 LPP + +PA QGA+ +ECR DD R R LL L+ +R + RL Sbjct: 181 LSPFHWQVLPPTLLVPAPAQGALALECRQDDKRLRPLLEPLDDPSAGVRCGG-AGLMARL 239 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 GGCQ+ +G+ A+ + L A + + RG+ D E + ++ +E+ Sbjct: 240 AGGCQLALGALAQETPEGLQLLAWY------RGRSYQARGS--DPEAVAEAVFKEI 287 >UniRef50_B4D5X7 Porphobilinogen deaminase n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4D5X7_9BACT Length = 307 Score = 283 bits (724), Expect = 8e-75, Method: Composition-based stats. Identities = 109/277 (39%), Positives = 149/277 (53%), Gaps = 14/277 (5%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPL---AKVGGKG 60 + + TR S LA+ Q L A+ P + +E VTRGD LD L + GGKG Sbjct: 2 KSIILGTRASALAVAQVELTTKALAAAFPAMQIERREFVTRGDKKLDLSLLRANEAGGKG 61 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF KELE ALL D+AVHS+KD+P P GL + + ER D ++ +L LP Sbjct: 62 LFTKELEDALLNGSIDVAVHSLKDLPGHNPPGLDITAVLERAPTADVLITKQPQTLLDLP 121 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGL 179 G ++GTSS+RR QL RRPD+ + RGNV TRL KL + IILA AGL+RLG Sbjct: 122 QGVLLGTSSVRRARQLQWRRPDVRVEEWRGNVQTRLRKLAERDDVTGIILAQAGLERLGH 181 Query: 180 ESRIRAALPP----------EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVT 229 + E LPA+GQGA+ ++ R D + +L ++H ET L + Sbjct: 182 DLSAGRLETEHGKFYVTSLAEDLLPAIGQGAIALQSRADRAEVAAVLQKIDHRETHLAIR 241 Query: 230 AERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAP 266 AER + L G C +P+G +L+ G I +RA++ P Sbjct: 242 AERELQRLLAGDCALPVGVRTKLLPGGIAMRAILFGP 278 >UniRef50_Q9Y9J0 Probable porphobilinogen deaminase n=1 Tax=Aeropyrum pernix RepID=HEM3_AERPE Length = 307 Score = 282 bits (723), Expect = 9e-75, Method: Composition-based stats. Identities = 106/294 (36%), Positives = 158/294 (53%), Gaps = 8/294 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVV--ELVPMVTRGDVILDTPLAKVGGKGLFV 63 +R+A R S L+L Q ++L + + G+ + E+V + + GDV D PL +G G+F Sbjct: 3 VRVAARGSRLSLLQVEQALEEL-SRYAGVSMHWEVVRVKSAGDVWSDRPLESIGVVGVFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQG-LGLVTICEREDPRDAFVSNNYD-SLDALPA 121 +E++ A+ ADIAVHS+KD+P G L +V I R RDA +S ++ L Sbjct: 62 REVDRAVASGAADIAVHSLKDMPTSGYGGPLKIVYIASRPSARDALISRQGPGRVEDLEP 121 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 GS +GTSS RR+ P + + +LRGN+ TRL KL G YDAII + AGL RLG++ Sbjct: 122 GSTLGTSSARRRALSLHYNPRIRVENLRGNLDTRLRKLREGLYDAIIASEAGLIRLGVDV 181 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 L P PA GQG V + R+ S ++L L+ AER + G Sbjct: 182 EYT-PLDPSYFPPAPGQGFVAVVARVG-SNVEKMLRDLDKPPWWHVAWAERGVLEGARAG 239 Query: 242 CQVPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 C+ P+ +YAE + + + A +PDGS+ G ++A ++G+SL EEL Sbjct: 240 CRTPVAAYAEPLGRSMVRVTAAALSPDGSRAYWARAEGRIEEARRIGVSLGEEL 293 >UniRef50_C5C5B3 Porphobilinogen deaminase n=6 Tax=Actinomycetales RepID=C5C5B3_BEUC1 Length = 334 Score = 282 bits (723), Expect = 1e-74, Method: Composition-based stats. Identities = 120/294 (40%), Positives = 155/294 (52%), Gaps = 25/294 (8%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASH-----PGLVVELVPMVTRGDVILDTPLAKV 56 LR+ TR S LA Q+ + + + A + VELV + T GD +L LA + Sbjct: 18 STRTLRVGTRASALATTQSEWAGEAIAARVAAATGSDVEVELVRVTTTGD-VLTGSLASM 76 Query: 57 GGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSL 116 GG G+FV L ALL+ R D+AVHS+KD+P GL L + +REDPRD + L Sbjct: 77 GGTGVFVTALREALLDGRCDVAVHSLKDLPTAAAPGLVLGAVPQREDPRDVLCARAGAGL 136 Query: 117 DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGL 174 LPAG VGT S RR QL RPDL I +RGNV TRLS++ G+ DA++LA AGL Sbjct: 137 ADLPAGGRVGTGSPRRAAQLRRARPDLEIVDIRGNVDTRLSRISPGKGDLDAVVLARAGL 196 Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECR-LDDSRTRELLAALNHHETALRVTAERA 233 RLG + AL + +PA GQGA+ +E L A + T L VTAERA Sbjct: 197 ARLGRLDAVTEALDAGVMVPAPGQGALAVEAVDAAPDWLLAGLRAFDDAPTRLAVTAERA 256 Query: 234 MNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMG 287 M RLE GC P+G+ A L ++ LR VG +DAE +G Sbjct: 257 MLARLEVGCSAPVGALATLAGSQLLLRTSVG----------------EDAEDLG 294 >UniRef50_Q0RS16 Porphobilinogen deaminase 1 (PBG 1) (Hydroxymethylbilane synthase 1) (HMBS 1) (Pre-uroporphyrinogen synthase 1) n=2 Tax=Frankia RepID=Q0RS16_FRAAA Length = 402 Score = 279 bits (714), Expect = 1e-73, Method: Composition-based stats. Identities = 121/366 (33%), Positives = 168/366 (45%), Gaps = 77/366 (21%) Query: 13 SPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLE 72 S LAL Q+ + +L G V+LVP+VT GD ++++GG G+FV L ALL Sbjct: 36 SALALTQSGMIAAQLRERV-GCAVDLVPIVTAGDR-SPAEISQIGGTGVFVSALRDALLA 93 Query: 73 NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRR 132 D+AVHS+KD+P P GL L + RED RD VS + L AL G+ V T + RR Sbjct: 94 GEIDLAVHSLKDLPTATPPGLVLAAVPTREDTRDVLVSPSGRGLAALGPGARVATGAPRR 153 Query: 133 QCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEIS 192 QL + ++RGNV TRL K +GE DA++LA AGL RL + L PE+ Sbjct: 154 AAQLRALGLGFDVVAIRGNVDTRLKKAIDGEVDAVVLAYAGLARLDRLDAVTEILDPEVM 213 Query: 193 LPAVGQGAVGIE------------------------------------------------ 204 LPA GQGA+ +E Sbjct: 214 LPAPGQGALAVECAAEAGLRLAGPARALVAAGAGDHADGDRPGAEAGRDGRGRGPDVGRN 273 Query: 205 ---CRLD-----DSRTRELLAA-LNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID- 254 R D D ELL L+ +++ + AERA +E GC P+G+ A Sbjct: 274 SGQTRSDHGQPLDGGLAELLRFVLDDASSSVAIRAERAFLAGIEAGCTAPVGALAVAEPA 333 Query: 255 -----------------GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 G + LRA+V APDGS ++R + G+ D E +G LA++LL+ Sbjct: 334 PAAAVGTVAPAGDASPAGRLRLRAVVAAPDGSTVLRRDVTGSAVDPEALGQRLADDLLSA 393 Query: 298 GAREIL 303 GA ++ Sbjct: 394 GAHSLM 399 >UniRef50_Q1GP41 Porphobilinogen deaminase n=7 Tax=Sphingomonadales RepID=HEM3_SPHAL Length = 315 Score = 278 bits (713), Expect = 1e-73, Method: Composition-based stats. Identities = 134/306 (43%), Positives = 169/306 (55%), Gaps = 10/306 (3%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGL--VVELVPMVTRGDVILDTPLAKVGGKG 60 DN LRI TR SPLA+ QAH L+A+H +E+VPM GD I D LA+VGGK Sbjct: 8 DNPLRIGTRASPLAMAQAHMAAAALIAAHGLAMAALEIVPMTATGDRIQDRALAEVGGKA 67 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLD 117 L+ +EL+ AL D+AVHS+KDV L + ER DPRD V + Sbjct: 68 LWTRELDAALDAGTIDVAVHSLKDVETLRDARFFLGAMLERADPRDRLVVREGIAAQKIS 127 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177 LP G+ +GTSS RR Q+ RPDL LRGNV TRL+KL GE DA +LA AGL+RL Sbjct: 128 ELPHGARLGTSSPRRAAQVRRLRPDLDTVLLRGNVATRLAKLAAGEADATLLAAAGLERL 187 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 G+ I A E+ LPA QGA+GIECR DD+ T LLAA++H T V AERA+ Sbjct: 188 GM-HDIGAVQGTELLLPAASQGAIGIECRADDAATIALLAAIDHAPTHRAVAAERALLAV 246 Query: 238 LEGGCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 L G C+ P+ +YAE DG + L A + + DG+ + G +L LL Sbjct: 247 LGGDCRSPVAAYAEWQADGVLRLDAEIFSEDGADHVAGHVIVTDAGVVA---ALGHRLLA 303 Query: 297 NGAREI 302 I Sbjct: 304 EAPPSI 309 >UniRef50_UPI000038E213 porphobilinogen deaminase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E213 Length = 285 Score = 273 bits (700), Expect = 5e-72, Method: Composition-based stats. Identities = 91/266 (34%), Positives = 139/266 (52%), Gaps = 8/266 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 + I TR S LAL QA+ VKD L + G V + + GD + PL ++ G+FV Sbjct: 2 PVTIGTRNSKLALIQANSVKDALESR--GYEVNIKSYTSAGDSNKNIPLYRMSSTGVFVD 59 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 EL +L+ D+AVHS KD+P +GL + + R+D RD +S L+ + AGS+ Sbjct: 60 ELNERVLKGEIDLAVHSAKDIPSNIQKGLEITAVTGRDDFRDVLISR--TPLEEMTAGSV 117 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSS+RR Q P++ + +RGN+ TR+SK +Y II+A+A KR+ L+ Sbjct: 118 IGTSSMRRIRQAMTVNPEITVSDIRGNIDTRISKYTEKKYTGIIIAMAAYKRMKLDIE-H 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L E LPA QG + I + + + + +N ET + ER + T L GC + Sbjct: 177 FILSEEQFLPAPNQGIIAIVGKSNSPASI-ISGEINDRETYRDMKNERFIATSLNLGCSM 235 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQ 270 P+G ++ DG+I R D + Sbjct: 236 PVGILSK--DGKIKTRFYSLDSDEHR 259 >UniRef50_A9V9E0 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V9E0_MONBE Length = 643 Score = 271 bits (693), Expect = 3e-71, Method: Composition-based stats. Identities = 99/206 (48%), Positives = 124/206 (60%), Gaps = 6/206 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LA+WQ +V ++L +HPG+ +VP+ T GD L L K G+F Sbjct: 417 IRIGTRSSVLAMWQTRWVVERLTRAHPGVRFSVVPLSTVGDANLTLDLNKFSTTGIFTDA 476 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS----LDALPA 121 L ALL DI VHS+KD+P G L I REDPRD V ++ S L LPA Sbjct: 477 LVRALLAQEVDILVHSLKDLPSTISPGTQLAAIGPREDPRDVVVFHHRHSEIKDLAQLPA 536 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN--GEYDAIILAVAGLKRLGL 179 G++VGTSS RR+ QLA P L +RGNV TRL KLD+ YDA+ LA AGL RLGL Sbjct: 537 GAVVGTSSTRRRAQLAAAYPQLRFAPVRGNVMTRLRKLDDPANGYDALCLAAAGLIRLGL 596 Query: 180 ESRIRAALPPEISLPAVGQGAVGIEC 205 E+RI LP +S A+GQGA+GI+ Sbjct: 597 EARIGQFLPLTVSRHAIGQGALGIQV 622 >UniRef50_Q83H95 Porphobilinogen deaminase n=2 Tax=Tropheryma whipplei RepID=Q83H95_TROW8 Length = 321 Score = 269 bits (688), Expect = 1e-70, Method: Composition-based stats. Identities = 109/331 (32%), Positives = 154/331 (46%), Gaps = 42/331 (12%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR S LA Q V+ + L + V + T D G FV Sbjct: 3 PLRIGTRSSLLATAQTAQVQKTMRDVFL-LDTQQVLIQTGSVRRRD---------GSFVA 52 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L ALLE D+AVHS+KD+P+ +G + + REDP D + +L LP+G+ Sbjct: 53 ALRTALLEGECDLAVHSLKDIPIAPHEGTLITAVLPREDPCDVLCARKDLTLTTLPSGAK 112 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGT+S RR+ Q+ RPDL + SLRGN+ RL LD DAI+L+ AGLKR+ E I Sbjct: 113 VGTASARRRAQILNFRPDLDVVSLRGNIDKRLIHLDT--LDAIVLSAAGLKRIDREDAIT 170 Query: 185 AALPPEISLPAVGQGAVGIE-CRL--DDSRTRELLA-ALNHHETALRVTAERAMNTRLEG 240 + A GQG++ IE CR DD + R + L++ + TAER + + L+ Sbjct: 171 ESFDIHDWPTAAGQGSLAIEVCRAQLDDPQNRVAVTYRLDNPMARVTTTAERGVLSLLQA 230 Query: 241 GCQVPIGSYA--ELIDGEIWLRALVGAPDGSQIIRG--------------------ERRG 278 C PI +A D + L A V + DG Sbjct: 231 DCFSPIAVHAVYTANDKSLRLHAKVFSRDGKIFCESIRFARLVKQLTDTNQNHTKNSGSD 290 Query: 279 APQDAEQMGISLAE----ELLNNGAREILAE 305 +A ++ ++LA+ ELL+ AREIL + Sbjct: 291 DIGNALEVAMTLAKTVVDELLSKNAREILKQ 321 >UniRef50_A5K0J5 Porphobilinogen deaminase, putative n=1 Tax=Plasmodium vivax RepID=A5K0J5_PLAVI Length = 341 Score = 268 bits (687), Expect = 2e-70, Method: Composition-based stats. Identities = 91/337 (27%), Positives = 147/337 (43%), Gaps = 69/337 (20%) Query: 45 GDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDP 104 GD ILD + GGKG+F KEL+ L++ I VHS+KDVP+E P+ + L +R+ Sbjct: 2 GDHILDKKVGLFGGKGIFTKELDEQLIKKNVHICVHSLKDVPMELPEHVQLSCFLKRDTI 61 Query: 105 RDAFVSNNYDSLDALPAGS---------------------------------------IV 125 DAF+S Y +L+ + + Sbjct: 62 NDAFLSVKYATLEDMNKRKMANKVEEESDQEKGTIQQMTNQGLKRDNCEGDKCTNFIPTI 121 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR Q+ ++ ++++RGN+ TR++KL NG+YDAII+A GL+RL + +R Sbjct: 122 GTSSLRRSSQIKYTYKNVAVKNVRGNINTRIAKLCNGQYDAIIIAKCGLERLLTKKVVRN 181 Query: 186 AL------PPEISL------------------------PAVGQGAVGIECRLDDSRTREL 215 + PPE L PA+ QG + + +D T + Sbjct: 182 IIRGKGKVPPEKFLLNHNDMETNLRLLRIQQINRRTIYPALCQGIIAVTSHKNDVDTSNI 241 Query: 216 LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE 275 L +N + + ER+ ++EG C +PIG YA+++ GEI A++ G + Sbjct: 242 LKNINDEKAQIMANVERSFLYQIEGNCMMPIGGYAQIVGGEIVFNAVINDTHGREKYHVR 301 Query: 276 RRGAPQDAEQMGISLAEELLNNGAREILAEVYNGDAP 312 G Q+ + A ++ ++ A Sbjct: 302 EVGTVQNCNNIAAMAATKMKEKIGTHRFNKIKEEAAQ 338 >UniRef50_UPI0001C31A39 porphobilinogen deaminase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31A39 Length = 314 Score = 266 bits (682), Expect = 6e-70, Method: Composition-based stats. Identities = 132/292 (45%), Positives = 169/292 (57%), Gaps = 13/292 (4%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +VLRI TR S LAL QA +V L G VE++P+ T GD +G K +V Sbjct: 2 SVLRIGTRASALALVQAEHVASLLRDG--GAQVEVIPITTSGDRGR-----LLGDKSRWV 54 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE ALL + D+AVHS KDVP E P G L + R D RDA SL+ LP G+ Sbjct: 55 KELEAALLADEVDVAVHSAKDVPAELPDGFVLAGVPARADARDALCG--AASLEQLPDGA 112 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +VGTSSLRR +L RPDL + +LRGNV TRL KL +G+ AI+LAVAGL+RL + I Sbjct: 113 VVGTSSLRRAAELRALRPDLGVVALRGNVDTRLRKLADGQAAAIVLAVAGLERLDRGAAI 172 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 A L + +PA GQGA+ +E R DD R R AA+ + A + AERA+ RL C Sbjct: 173 GAVL--DQLVPAPGQGALALETRADDDRARAAAAAITDADAAACLAAERALVRRLGATCH 230 Query: 244 VPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAPQ-DAEQMGISLAEE 293 P+G++A DG + LR+ VG PDGS +R E A D E G++ Sbjct: 231 TPLGAHAVRTADGGLRLRSFVGLPDGSAWLRDELSAAAGIDPETFGVAAGTR 282 >UniRef50_A7BMK1 Porphobilinogen deaminase n=1 Tax=Beggiatoa sp. SS RepID=A7BMK1_9GAMM Length = 211 Score = 264 bits (675), Expect = 4e-69, Method: Composition-based stats. Identities = 123/208 (59%), Positives = 147/208 (70%), Gaps = 1/208 (0%) Query: 101 REDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD 160 RE+P DAFVSN Y +L ALP G+IVGTSSLRRQ QL RPDL IRSLRGNVGTRLSKLD Sbjct: 3 REEPFDAFVSNTYATLAALPEGAIVGTSSLRRQSQLLAHRPDLQIRSLRGNVGTRLSKLD 62 Query: 161 NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALN 220 NG+YDAI+LA GLKRLGL RIR + I LPA+GQGA+GIECR DD TR+ + LN Sbjct: 63 NGDYDAIVLAAVGLKRLGLVERIREIIDSTIMLPAIGQGAIGIECRQDDLETRQHIDNLN 122 Query: 221 HHETALRVTAERAMNTRLEGGCQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGA 279 +T V AERA+N LEGGCQVPI YAE+ + +R LVG +G I+R +GA Sbjct: 123 DPDTQDCVIAERALNESLEGGCQVPIAGYAEIQSSENLTMRGLVGDIEGQHILRHNLQGA 182 Query: 280 PQDAEQMGISLAEELLNNGAREILAEVY 307 A ++G SLA+ LL GA +IL ++ Sbjct: 183 RHLAAELGKSLAKVLLTQGAAQILEKLK 210 >UniRef50_B0SF66 Bifunctional porphobilinogen deaminase/uroporphyrinogen synthase n=2 Tax=Leptospira biflexa serovar Patoc RepID=B0SF66_LEPBA Length = 511 Score = 263 bits (674), Expect = 5e-69, Method: Composition-based stats. Identities = 90/314 (28%), Positives = 137/314 (43%), Gaps = 37/314 (11%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + ++I R S L+ Q H V + L + L E + + GD L TPL + GG+G+ Sbjct: 1 MSETIKIGGRSSLLSRIQIHTVTNALKEKNKDLNFETIFRESSGDKDLTTPLWQFGGQGI 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F K+L+ LL ++ DI +HS KD+ ++ + L+ + RED RD + ++ LP Sbjct: 61 FTKDLQEDLLNHKVDIVIHSYKDMDLKERKETTLIPVLPREDVRDVLLFKKNKWIN-LPN 119 Query: 122 GSIVGTSSLRRQC----QLAERRPD------LIIRSLRGNVGTRLSKLDNGEYDAIILAV 171 + TSS RR+ L P + I S+RGN+ TRL K + E I++A Sbjct: 120 EITILTSSPRREYHIKEFLRNYFPTPINNFEIKIESVRGNIQTRLRKYLDHESGGILVAK 179 Query: 172 AGLKR-LGLES---------RIRA------------ALPPEISLPAVGQGAVGIECRLDD 209 A L R L + I+ LP I A QGA+ E R +D Sbjct: 180 AALDRILNFQDPDQLLPELKEIQQLIKDTMNVSLFMVLPSSIFPSAPAQGALCAEIRKED 239 Query: 210 SRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYA--ELIDGEIWLRALVGAPD 267 LL+ ++ ET L ER + +R GGC IG ++R + D Sbjct: 240 KHLETLLSKISDSETNLTTNEEREILSRYGGGCHQKIGVTVLHREYGKVCFIRGI--TED 297 Query: 268 GSQIIRGERRGAPQ 281 G + E +P Sbjct: 298 GQILQTKELSESPN 311 >UniRef50_Q86ET2 Clone ZZD1450 mRNA sequence n=3 Tax=Schistosoma japonicum RepID=Q86ET2_SCHJA Length = 277 Score = 263 bits (674), Expect = 5e-69, Method: Composition-based stats. Identities = 100/329 (30%), Positives = 137/329 (41%), Gaps = 75/329 (22%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + +R+ +R+S LAL Q L P ++ E+V + T GD ILD PL+K+G K L Sbjct: 6 SQHAVRVGSRRSNLALLQTEMAISLLKVQKPHIMFEVVEIATVGDEILDVPLSKIGDKSL 65 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS---NNYDSLDA 118 F KELE +LL D+ VHS+KDVP P GL L + R P D + N L Sbjct: 66 FTKELEKSLLVGEVDLVVHSLKDVPSVLPTGLVLGCVFGRSSPEDVVLMAPHNRGMKLSD 125 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG--------------EY 164 LP G+ VGTSS+RR L + P L S+RGN+ TRL+KLD Y Sbjct: 126 LPVGATVGTSSIRRVATLIRKYPHLKFISIRGNLNTRLAKLDTPSNLQKQCCTGNQSLSY 185 Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224 DA+ILA AG++R+G RI L DS L + Sbjct: 186 DALILAKAGVERMGWVDRIDQVLS--------------------DSFYANELKGALDASS 225 Query: 225 ALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAE 284 +G LR + A+ Sbjct: 226 VF-------------------MGVAVTPSSEVSRLRMAI-------------------AQ 247 Query: 285 QMGISLAEELLNNGAREILAEVYNGDAPA 313 +G +A+ LL +GA EIL E+ + + Sbjct: 248 SLGCIVAKYLLLSGAGEILHEIRSQSTES 276 >UniRef50_Q04X38 Bifunctional porphobilinogen deaminase/uroporphyrinogen synthase n=4 Tax=Leptospira RepID=Q04X38_LEPBL Length = 542 Score = 263 bits (672), Expect = 7e-69, Method: Composition-based stats. Identities = 89/285 (31%), Positives = 127/285 (44%), Gaps = 32/285 (11%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + VL+IA+R+S LA Q + V D L P + +EL GD+ L TPL K+G +G+ Sbjct: 1 MSRVLKIASRKSALAKLQTYLVLDALKKKFPNIQIELHFREASGDLDLQTPLWKMGTRGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F ++L L+E + D+ +HS KD+ +E G +V + +R D RD + P+ Sbjct: 61 FTQDLTKDLVEKKVDLVIHSWKDLDLEGHSGTTIVGVLDRADQRDVLLWKKSSLSKNFPS 120 Query: 122 GSIVGTSSLRRQCQLAERRPD----------LIIRSLRGNVGTRLSKLDNGEYDAIILAV 171 + TSS RR+ L + + LI +RGN+ TR+ K N + D ++LA Sbjct: 121 ELKIQTSSPRREYNLKKFLNNSLPSRYKNSSLIFLPVRGNIQTRIRKWRNSDSDGLVLAK 180 Query: 172 AGLKRL----------------------GLESRIRAALPPEISLPAVGQGAVGIECRLDD 209 A L RL LE I LP +S A QGA+ E R DD Sbjct: 181 AALDRLLSEDFLNSNELEYQEIRKFLKEILEESIFQVLPLSLSPSAPAQGAIAAEVRTDD 240 Query: 210 SRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID 254 + AL+ E V ER R GGC IG Sbjct: 241 EWALGFVRALSKPEVVSAVEEERNTLKRFGGGCHQKIGVSVLYKS 285 >UniRef50_B1ZV87 Porphobilinogen deaminase n=2 Tax=Opitutaceae RepID=B1ZV87_OPITP Length = 284 Score = 254 bits (650), Expect = 3e-66, Method: Composition-based stats. Identities = 96/260 (36%), Positives = 128/260 (49%), Gaps = 15/260 (5%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L +ATR+SPLAL Q V L A G+ EL+ +VT GD + L + GGKGLF Sbjct: 2 KKLILATRKSPLALRQTEMVAAHLEARL-GVQTELLKLVTTGDRQTEWSLEQKGGKGLFT 60 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 ELE AL AD+AVHS KD+P + L + R D RD V + A Sbjct: 61 SELENALRRGEADLAVHSTKDLPGDMAAELAVAGYLPRADARDVLVLRAG-----VAAPK 115 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESR 182 + T S RR+ Q+A+ P + +RGNV TRL K+ G D +LA AGL RLG+ + Sbjct: 116 SLATGSPRRRLQIAKLYPGVTFTEIRGNVDTRLKKIGELGVADGTVLASAGLNRLGIGNW 175 Query: 183 IR---AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 AL +PAVGQGA+ ++CR D+ A + T V ERA L Sbjct: 176 PGVEFHALGFNDMVPAVGQGAIAVQCRAADAA---RFAPVFDAATKRAVDVERAFQAALG 232 Query: 240 GGCQVPIGSYAELIDGEIWL 259 GCQ G++ + + Sbjct: 233 VGCQTAFGAH--VAGDTLHF 250 >UniRef50_Q6MHU0 Hydroxymethylbilane synthase n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MHU0_BDEBA Length = 502 Score = 239 bits (610), Expect = 1e-61, Method: Composition-based stats. Identities = 82/290 (28%), Positives = 123/290 (42%), Gaps = 37/290 (12%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LRI+ R+S LA QA+ V D L +P + ++ + GD L PL K+ KG+F ++ Sbjct: 3 LRISARKSDLARLQAYMVGDALKEKNPQIEIDYRFRESLGDKNLTDPLWKIPEKGVFTED 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-----DSLDALP 120 LL + D+ VHS KD+P E + R D RD + + L Sbjct: 63 FFGELLRDETDLVVHSWKDLPTEHKSETVIAATLPRADQRDLLLVKKSHFDKIKTSKTL- 121 Query: 121 AGSIVGTSSLRRQCQL----AERRP----DLIIRSLRGNVGTRLSKL-DNGEYDAIILAV 171 V +SS RR+ L E P D+ S+RGN+ TR+ KL ++ E D +I+A Sbjct: 122 ---KVFSSSPRREYNLTGFFKEHLPFGLQDVKFESVRGNMLTRVRKLIESPETDGLIVAK 178 Query: 172 AGLKRLG-----------------LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRE 214 A RL LP ++ A QGA+ +E ++ Sbjct: 179 AAFDRLFSATLPEFLEGQQQLRQYFNELNWVVLPLSVNPNAAAQGALAVEVLKSRQDLQD 238 Query: 215 LLAALNHHETALRVTAERAMNTRLEGGCQVPIG--SYAELIDGEIWLRAL 262 LL +++H +T ER + + GGC IG A L+ L Sbjct: 239 LLQSIHHADTFHCSQKERDVLSSFGGGCHQKIGVAVLARPYGQITLLKGL 288 >UniRef50_C0EAN0 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum DSM 5476 RepID=C0EAN0_9CLOT Length = 292 Score = 238 bits (607), Expect = 3e-61, Method: Composition-based stats. Identities = 87/293 (29%), Positives = 128/293 (43%), Gaps = 16/293 (5%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 + I Q+ L+ A ++ L + HP L ELVP+ G T L Sbjct: 13 EKIHIGCAQNELSRNFADHLAQCLHSYHPELTAELVPIKNTGADEEPT---------LVA 63 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 + LE AL++ R D+AV+ D+P+E L +V I RED RDA V P S Sbjct: 64 RRLEQALIDCRVDLAVYHALDLPLELHPELPIVAISSREDVRDALVFPQG---KQQPDFS 120 Query: 124 I-VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 +G +S R+Q QL PD I + G V +L++LD GEY A++L A L GL+ R Sbjct: 121 KPIGCTSRRQQVQLHRVFPDCITAPVGGTVAEQLARLDQGEYGALVLPAAQLGWFGLQQR 180 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 + E +PA G A+ ++ R + LL + ++ V ER LE Sbjct: 181 VGQLFCVEELVPAAGHAAIAVQAREEFD--AGLLECFHSWDSWDAVFCEREFARALEEE- 237 Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295 PI +AE+ + + G +DA ++G LA EL Sbjct: 238 PGPIAVHAEVKGETLSVVGFYADEAEGIYRMSSMSGDRKDAGRLGFELAAELK 290 >UniRef50_Q4E9D5 Porphobilinogen deaminase (Fragment) n=1 Tax=Wolbachia endosymbiont of Drosophila ananassae RepID=Q4E9D5_9RICK Length = 199 Score = 233 bits (595), Expect = 6e-60, Method: Composition-based stats. Identities = 81/202 (40%), Positives = 121/202 (59%), Gaps = 6/202 (2%) Query: 97 TICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRL 156 + ER P DAF+S+ ++SL++LP + + TS++RR+ QL RPDL I LRGNV TR Sbjct: 1 CVLERLSPCDAFISHKHNSLESLPQQATIATSAIRRKVQLLNFRPDLNIVPLRGNVTTR- 59 Query: 157 SKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELL 216 L N +D IILA AGL RL I LPP++ L AVGQGA+ I+CR +D + +LL Sbjct: 60 --LQNQSFDGIILAEAGLIRLEKHHLITEVLPPKVMLSAVGQGAICIQCRRNDVKIIDLL 117 Query: 217 AALNHHETALRVTAERAMNTRLEGGCQVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGE 275 +N++ + + V +ER+ + G C P+ + AE + + ++LR ++ DG I E Sbjct: 118 EKINNNMSFIGVKSERSFMKTVNGSCFTPLAALAEYVSENMLYLRCMLA--DGKNIYFTE 175 Query: 276 RRGAPQDAEQMGISLAEELLNN 297 R +DAE+MG+ EL + Sbjct: 176 RTSFIEDAEKMGMDAGLELKSK 197 >UniRef50_A8I2X7 Porphobilinogen deaminase n=1 Tax=Chlamydomonas reinhardtii RepID=A8I2X7_CHLRE Length = 380 Score = 230 bits (588), Expect = 4e-59, Method: Composition-based stats. Identities = 102/319 (31%), Positives = 138/319 (43%), Gaps = 36/319 (11%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVEL----VPMVTRGDVILDTPLAKVGG 58 L IATR S LA Q V+ L+A+ +L + + +RGD L +G Sbjct: 60 QRPLVIATRPSKLAKEQTRQVQQLLLAAAQLKDEQLQLSTLELASRGDTTQGVSLRSLG- 118 Query: 59 KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118 G F +EL+ A+L AD++VHS+KD P GL L R DPRD ++ SL Sbjct: 119 SGAFTEELDQAVLSGAADMSVHSLKDCPAALAPGLLLAACLPRADPRDVLIAPEATSLGE 178 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 L GS VGTSS RR Q+ P L + LRGNV +RL ++ + + A +LA AGLKRLG Sbjct: 179 LVPGSRVGTSSSRRAAQIKHSFPHLQVVQLRGNVDSRLGRIRSRDIGATVLAAAGLKRLG 238 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR- 237 + + GAVG+ CR DD LL A++H TAL V AERA Sbjct: 239 VMNSDEGD--------TTATGAVGVVCRADDEWVVGLLDAISHRGTALEVAAERACLAAL 290 Query: 238 --------------LEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER----RGA 279 + C + + L LV +G ++ R Sbjct: 291 LGGGGACQRSAFPDIAWACHTRH----DPDSNTMDLDCLVADLEGKELFRYTEFYRPVID 346 Query: 280 PQDAEQMGISLAEELLNNG 298 DA +G L Sbjct: 347 EVDAVSLGSLYGSLLRMMA 365 >UniRef50_B6YQR9 Hydroxymethylbilane synthase/uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YQR9_AZOPC Length = 682 Score = 229 bits (586), Expect = 7e-59, Method: Composition-based stats. Identities = 80/226 (35%), Positives = 119/226 (52%), Gaps = 18/226 (7%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG- 60 LR+ +R SPL+L Q V + P + +L+ + + GD L + Sbjct: 7 SKGNLRVISRNSPLSLLQVKEV----FSFFPNIDYQLITIESFGDKNKHVALFDISNVSS 62 Query: 61 ----------LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS 110 F +EL+ AL+ N+ADIAVHS KD+P P L L + + D D+ +S Sbjct: 63 FFLEEESISDFFTRELDEALIYNKADIAVHSAKDLPYPLPYDLELFALFQAMDKSDSLIS 122 Query: 111 NNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILA 170 N +L+ LP + VGTSS +R+ +L + RPDL + S+RGN+ R++K+DNG DA+I+A Sbjct: 123 RNNLTLEQLPPRARVGTSSQKRKTELLKIRPDLEVVSIRGNIEERIAKMDNGFIDALIVA 182 Query: 171 VAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELL 216 L RLG+E+RI LP E QG + I R +D + L Sbjct: 183 TCALIRLGMEARIACILPFETH---SLQGNLAIVGRKNDKNVKNLF 225 >UniRef50_B4UXX3 Porphobilinogen deaminase 2 (Fragment) n=1 Tax=Streptomyces sp. Mg1 RepID=B4UXX3_9ACTO Length = 231 Score = 227 bits (580), Expect = 3e-58, Method: Composition-based stats. Identities = 88/231 (38%), Positives = 120/231 (51%), Gaps = 13/231 (5%) Query: 1 MLDN-----VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAK 55 M+ + +R+ TR SP+AL Q D A +P +V+++V +V+ GD PL+ Sbjct: 1 MMTSSTDLTTVRLGTRPSPMALEQTGRFADVFRARYPQVVLDIVEIVSEGDRHRG-PLST 59 Query: 56 VGGKGLFVKELEVALLENRADIAVHSMKDVPVEFP--QGLGLVTICEREDPRDAFVSNNY 113 +GGKG F + + LL+ R + KDVP G+ + + RED RDA V Sbjct: 60 IGGKGAFTRNADRYLLDGRVQATIACAKDVPGPHDRSPGIVIAAVLPREDTRDALVLPTG 119 Query: 114 ---DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDA--II 168 +L LP G+ VGTS+ RR L P L+ +RGN +RL LD G A +I Sbjct: 120 HPVTTLAELPPGTRVGTSAPRRSALLKALHPTLVQVPIRGNADSRLRALDAGRLGADVMI 179 Query: 169 LAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAAL 219 A+AGL+RLG E R L P + LPA G G V +E R DD T LLA L Sbjct: 180 AALAGLRRLGHEDRASEILDPAVWLPAAGAGTVIVEHRSDDPATGWLLAPL 230 >UniRef50_Q6MEK3 Putative Porphobilinogen deaminase n=2 Tax=Parachlamydiaceae RepID=Q6MEK3_PARUW Length = 233 Score = 221 bits (564), Expect = 3e-56, Method: Composition-based stats. Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 3/218 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 + + R SPL+ Q + L + +P + + T GD+ T L + F KE Sbjct: 18 ISVGARSSPLSRAQVQEILKALRSFYPSIEFTISYFDTIGDLDQKTSLRDLDKTNFFTKE 77 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 ++ A+L+ + I +HS KD+P P GL L+ + + D D V + ++L LP S + Sbjct: 78 IDEAILQKKCQIGIHSAKDLPDPIPDGLQLICLTKGVDCSDVLVLRDGETLQTLPPHSRI 137 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 TSS+RR+ + R D I LRG + RL+ L+ + D +++A A L RLGL R Sbjct: 138 ATSSIRRENIVKLLRNDFIFLDLRGTIHQRLALLEKKQADGVVVAEAALIRLGLTHLNRI 197 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHE 223 LP GQG + I R DD++ + L A L+ + Sbjct: 198 RLPGTTV---EGQGQLAIIARKDDAKMQTLFACLDVRK 232 >UniRef50_Q6Q923 Predicted porphobilinogen deaminase n=2 Tax=environmental samples RepID=Q6Q923_9GAMM Length = 291 Score = 211 bits (537), Expect = 3e-53, Method: Composition-based stats. Identities = 81/251 (32%), Positives = 113/251 (45%), Gaps = 15/251 (5%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 ++IA+R S LAL Q K +++ + T GD I + K FV Sbjct: 2 TIKIASRSSKLALAQVEEFVKK----FGISDYKIIKVKTEGD-IKSANGETLFDKAHFVS 56 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 +++ LL ADIAVHS KD P GL L + +D + D ++ Sbjct: 57 DVQKCLLNGEADIAVHSAKDTPAGETTGL-LRYFLPSQSNQDVLIFREEDKFNS---EMK 112 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSSLRRQ Q + I +L GNV TRL KL GEYD IILA AGL RL L + ++ Sbjct: 113 LGTSSLRRQLQAKHHLNAINIVNLSGNVDTRLEKLSQGEYDCIILAKAGLARLKLLNELQ 172 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSR--TRELLAALN--HHETALRVTAERAMNTRLEG 240 + A GQG + IE D S LL ++ ++ ER++ + Sbjct: 173 YEVM--DWSTASGQGFLCIEVLNDPSADIYNFLLKSIREIDLNLGKNISTERSILEAINA 230 Query: 241 GCQVPIGSYAE 251 GC I + Sbjct: 231 GCNSAISIQTQ 241 >UniRef50_Q9PK95 Probable porphobilinogen deaminase n=13 Tax=Chlamydiaceae RepID=HEM3_CHLMU Length = 242 Score = 208 bits (530), Expect = 2e-52, Method: Composition-based stats. Identities = 69/199 (34%), Positives = 104/199 (52%), Gaps = 5/199 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LR+A+R+SPLA+ QAH +L P L +++ T+GD+ TPL V G F Sbjct: 20 PLRLASRKSPLAVLQAHECLRRLQTFFPRLWGQVITETTQGDLDQHTPLHSVENTGFFTD 79 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 +++ + + D+A+HS KD+P E P+ + I DPRD V L P+ Sbjct: 80 DIDFLVQSGKCDLAIHSAKDLP-EKPKARVI-AITASIDPRDILVFQEKYLLQPFPSRLR 137 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +G SS RR+ ++ P +I +RG + TRL+ LD ++DAI++A A + RLGL Sbjct: 138 IGCSSDRRRALISSLYPSAVITDIRGTIQTRLALLDQQKFDAIVMANAAVSRLGLRLPCT 197 Query: 185 AALPPEISLPAVGQGAVGI 203 LPP QG + I Sbjct: 198 VVLPPPYH---PFQGRLAI 213 >UniRef50_C5LJF7 Porphobilinogen deaminase, putative n=5 Tax=Perkinsus marinus ATCC 50983 RepID=C5LJF7_9ALVE Length = 556 Score = 205 bits (523), Expect = 1e-51, Method: Composition-based stats. Identities = 87/367 (23%), Positives = 133/367 (36%), Gaps = 60/367 (16%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 +VL I +R+S LA Q + D L G+ VE GD L PL K+ G+F Sbjct: 7 PSVLHIGSRRSDLARLQTLMIADLLQDEM-GVKVECHYREAPGDTNLKDPLWKMPETGVF 65 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 L L+ D+ VHS KD+P+ G +V R DPRD + + G Sbjct: 66 TSFLRDGLMNGAFDLVVHSWKDLPLAEESGTTVVATLPRADPRDLLLIRRDAIEEMTSEG 125 Query: 123 SI--VGTSSLRRQCQLAERRP-------DLIIRSLRGNVGTRLSKLDNGEY--------- 164 V +SS RRQ L + R +RGN+ TR+ KL + Sbjct: 126 GKLIVLSSSPRRQFNLTPFLESVVPGVTSVQFRDVRGNIQTRMKKLMDPTIHDESLGCRP 185 Query: 165 DAIILAVAGLKRL----------------GLESRIRA-ALPPEISLPAVGQGAVGIECRL 207 +++A A + R G S R LP + A QGA+GIE Sbjct: 186 HGLVVAKAAVDRFIRSTREEFKESRQLVQGYISECRCMVLPLSANPTAAAQGALGIEVST 245 Query: 208 --DDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGS--YAELIDGEIWLRALV 263 + R+++ +LN T + E+ + GGC IG ++L Sbjct: 246 APEKEHVRKIVRSLNDRSTFDAASKEKELLNSYGGGCHQKIGCTILPRQYGDVLFLCGR- 304 Query: 264 GAPDGSQIIRGE-------------RRGAPQDAEQMGISLAEELLN-----NGAREILAE 305 +G ++ R G Q+G + L + +++ Sbjct: 305 -TDNGLDLLDRHIKPRIPLLEDLHLREGEDPPPLQVGGAGGLSLFDREEDPQAGGKLIEA 363 Query: 306 VYNGDAP 312 + GD Sbjct: 364 LRKGDRE 370 >UniRef50_Q9HMY5 Probable porphobilinogen deaminase n=2 Tax=Halobacterium salinarum RepID=HEM3_HALSA Length = 396 Score = 203 bits (517), Expect = 7e-51, Method: Composition-based stats. Identities = 72/165 (43%), Positives = 96/165 (58%), Gaps = 2/165 (1%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M +R+ATR S LAL QA V D L VELV + T GD + D ++ +G G Sbjct: 1 MSSQQIRLATRGSDLALRQAGEVVDTLEDR--RHDVELVEVETEGDRVTDALISDLGKTG 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 FV+ L+ ++E D AVHSMKDVP E P+ L + + RE+P D V+ + L+ LP Sbjct: 59 AFVRALDQEVMEGTVDAAVHSMKDVPTEVPEDLVVAAVPHRENPADVLVTPDGTDLEDLP 118 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYD 165 AGS+VGT+SLRR Q+ RP L + +RGNVGTR+ KL Sbjct: 119 AGSVVGTASLRRGAQVQAHRPGLDVEPIRGNVGTRVEKLLAPALH 163 Score = 137 bits (345), Expect = 7e-31, Method: Composition-based stats. Identities = 48/149 (32%), Positives = 70/149 (46%), Gaps = 1/149 (0%) Query: 163 EYDAIILAVAGLKRLGLESRIR-AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNH 221 EYDA+++A GL+R GL + L +PA GQGA+ + R D L AL H Sbjct: 248 EYDALVMARVGLERTGLLHHVGIEELSTGTHVPATGQGALCVTARRDSDVVDTLRDALEH 307 Query: 222 HETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ 281 T + VTAER + L GGC PIG +A + I V + DGS+ + R + Sbjct: 308 VRTRVEVTAERVVLEELGGGCIAPIGVHALVQGDTIRTAVQVFSQDGSEQVGETRELDAE 367 Query: 282 DAEQMGISLAEELLNNGAREILAEVYNGD 310 LA +L + GA +++ + Sbjct: 368 QYATDARELAADLRDRGAADLIEDARTEA 396 >UniRef50_D0RNS6 Putative porphobilinogen deaminase (Pbg)(Hydroxymethylbilane synthase) (Hmbs) (Pre-uroporphyrinogen synthase) n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RNS6_9RICK Length = 492 Score = 203 bits (516), Expect = 1e-50, Method: Composition-based stats. Identities = 79/295 (26%), Positives = 121/295 (41%), Gaps = 28/295 (9%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + L I +R S LA Q VK +L + + T+GD K G G+ Sbjct: 1 MSLSLIIGSRASFLAKIQTFIVKQELKKKIKNIKITTKYHSTKGDKNQGHMPWKNLGYGI 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F L L+ + VHS KD+PV + + R+DPRD Sbjct: 61 FTTSLTNELINKNFNCVVHSYKDLPVL--KSKTDYYVITRDDPRDV---LLVKKKCLNKK 115 Query: 122 GSIVGTSSLRRQCQLAERRP-----DLIIRSLRGNVGTRLSK-LDNGEYDAIILAVAGLK 175 IVGTSS RR+ + + + D+ +++RGNV TRL K + +YDA+ +A A + Sbjct: 116 KFIVGTSSPRRKSSVKDLKDLTGIKDIKTKTIRGNVTTRLLKVISKNQYDAVFMAKAAID 175 Query: 176 R----------------LGLESRIR-AALPPEISLPAVGQGAVGIECRLDDSRTRELLAA 218 R L L + + LP I A QGA+ +E +D +T+ L Sbjct: 176 RIFKYGNKVDKVETKKFLNLFKKFKPFILPLSIFPTAASQGAIAVEYLKNDKKTKSTLNK 235 Query: 219 LNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIR 273 +N +T ER++ + GGC + IG E I +L + + Sbjct: 236 INCKKTLSICNQERSLLKKYGGGCGLDIGITIEEIKNNNFLFSKGVDARNKKEFH 290 >UniRef50_Q18ES3 Hydroxymethylbilane synthase (Porphobilinogen deaminase) n=9 Tax=Halobacteriaceae RepID=Q18ES3_HALWD Length = 394 Score = 187 bits (477), Expect = 3e-46, Method: Composition-based stats. Identities = 66/162 (40%), Positives = 95/162 (58%), Gaps = 4/162 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 L +ATR S LAL QA V++ L V+L+ + TRGD I D + ++G G FV+ Sbjct: 10 TLTLATRGSDLALKQATSVQEALTDE--RYEVDLIEVETRGDQIQDELIHQLGKTGAFVR 67 Query: 65 ELEVALLE--NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 L+ +L+ AD AVHSMKD+P + P L + I +R P D ++ + L LP+G Sbjct: 68 ALDKKVLDPTAEADAAVHSMKDMPTDSPDDLVVAGIPQRAPPGDLLITTDGQRLSDLPSG 127 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY 164 + +GTSSLRRQ QL ++R D+ + LRGN+ TR+ KL Sbjct: 128 ATIGTSSLRRQAQLLDQRTDITVEPLRGNIDTRIEKLLAPSL 169 Score = 134 bits (337), Expect = 6e-30, Method: Composition-based stats. Identities = 52/153 (33%), Positives = 76/153 (49%), Gaps = 1/153 (0%) Query: 156 LSKLDNGEYDAIILAVAGLKRLGLESRIRAA-LPPEISLPAVGQGAVGIECRLDDSRTRE 214 L + EYDAI+LA AGL+R GL I L +PA GQGA+ I + + + T + Sbjct: 228 LERSVETEYDAIVLAEAGLQRSGLIHHIEYVQLDTTTFVPAPGQGAIAITTQGEANATAQ 287 Query: 215 LLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRG 274 + A++H T + T ER + L GGC PIG +A L + + A V A DG++ + G Sbjct: 288 IREAIDHPRTRVETTVERTVLAELGGGCIAPIGVHATLQGEYVHVAAQVFASDGTETVDG 347 Query: 275 ERRGAPQDAEQMGISLAEELLNNGAREILAEVY 307 R A +L + GA E++A Sbjct: 348 SRNLPVDAHADAAAQFANKLADRGADELIAAAR 380 >UniRef50_UPI000155526F PREDICTED: similar to hydroxymethylbilane synthase n=1 Tax=Ornithorhynchus anatinus RepID=UPI000155526F Length = 218 Score = 174 bits (442), Expect = 4e-42, Method: Composition-based stats. Identities = 60/130 (46%), Positives = 78/130 (60%), Gaps = 9/130 (6%) Query: 75 ADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALPAGSIVGTSSLR 131 D+ VHS+KD+P P G + +C+RE P DA V + +L LP S+VGTSSLR Sbjct: 90 VDLVVHSLKDLPTVLPPGFTIGAVCKRESPYDAVVFHPKHVGKTLATLPEKSVVGTSSLR 149 Query: 132 RQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESRIRAALPPE 190 R QL + P L +S+RGN+ TRL KLD E+ AIILA AGL+RLG +SR+ Sbjct: 150 RAAQLQRKFPHLEFKSIRGNLNTRLRKLDELQEFSAIILAAAGLQRLGWQSRLGQV---- 205 Query: 191 ISLPAV-GQG 199 PA G+G Sbjct: 206 RVAPAPRGRG 215 >UniRef50_B0KCR7 Porphobilinogen deaminase n=3 Tax=Thermoanaerobacter RepID=B0KCR7_THEP3 Length = 168 Score = 163 bits (413), Expect = 8e-39, Method: Composition-based stats. Identities = 48/162 (29%), Positives = 78/162 (48%), Gaps = 3/162 (1%) Query: 136 LAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPA 195 + D+ I +RGNV TRL K++ D I+L+ AGL RLGLES I PP++ +PA Sbjct: 4 IQALMSDIQIVPIRGNVRTRLKKMEELNLDGIVLSAAGLHRLGLESIITEYFPPDVVVPA 63 Query: 196 VGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAEL-- 252 QG + +E D+ +E + + T + ER + C+ P G+YA+ Sbjct: 64 PCQGILAVEIAESFDNIFQEFYSYIVDRRTFFEASVERELLKAFGVNCRQPFGAYAQYRK 123 Query: 253 IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 E + V ++++ E G ++ ++M L EE Sbjct: 124 EKDEEKINIKVVYQKEDKLLKSEVTGLIEETDKMIEKLIEEF 165 >UniRef50_C0DZX9 Putative uncharacterized protein n=1 Tax=Corynebacterium matruchotii ATCC 33806 RepID=C0DZX9_9CORY Length = 152 Score = 152 bits (385), Expect = 2e-35, Method: Composition-based stats. Identities = 54/151 (35%), Positives = 79/151 (52%), Gaps = 1/151 (0%) Query: 156 LSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTREL 215 ++K+ +GE DA++LA AGL R+ P LPA QGA+ +ECR DD+ T Sbjct: 1 MAKVHDGELDAVVLAYAGLSRVHRADEATEVFDPLEFLPAPAQGALAVECRADDADTIAA 60 Query: 216 LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEI-WLRALVGAPDGSQIIRG 274 + + + ER + RLE GC P+ +YA + I L A V A DGS +R Sbjct: 61 ITTIADSKAYACAHTERVVLARLEAGCTAPVAAYATVAADNIMTLHAAVIAMDGSATLRA 120 Query: 275 ERRGAPQDAEQMGISLAEELLNNGAREILAE 305 G AE +G+++A LL++GA +LA Sbjct: 121 TAAGPIDTAENLGMTVARALLDDGASSLLAA 151 >UniRef50_UPI0001B4213A porphobilinogen deaminase n=1 Tax=Listeria monocytogenes LO28 RepID=UPI0001B4213A Length = 128 Score = 142 bits (358), Expect = 2e-32, Method: Composition-based stats. Identities = 51/124 (41%), Positives = 78/124 (62%), Gaps = 2/124 (1%) Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 +PPE+ LPAVGQGA+ IECR D + R++L +++H ET + V AER +L GGC++ Sbjct: 6 EDIPPEVCLPAVGQGALAIECRESDQQIRDMLTSIHHEETGICVEAERVFLKKLNGGCEI 65 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 PI +A + + + LVG DGS I+ E+ G + ++G +AE+LL+ GA I+ Sbjct: 66 PIAGFATRANEFVQFKGLVGNADGSIILESEQVG--ANPSEIGNKVAEDLLSEGADTIIK 123 Query: 305 EVYN 308 E+ N Sbjct: 124 ELRN 127 >UniRef50_A8CBG6 Porphobilinogen deaminase n=3 Tax=Toxoplasma gondii RepID=A8CBG6_TOXGO Length = 747 Score = 141 bits (356), Expect = 3e-32, Method: Composition-based stats. Identities = 56/163 (34%), Positives = 74/163 (45%), Gaps = 33/163 (20%) Query: 124 IVGTSSLRRQCQLAERRP--DLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL-- 179 +GT SLRRQ L P + LRGNV TR+S+++ G DA +LA AGLKRL L Sbjct: 444 RIGTCSLRRQALLYALLPPSSFQLMGLRGNVQTRMSRIEKGTLDATLLAAAGLKRLNLLS 503 Query: 180 ---------------------ESRIRAA--------LPPEISLPAVGQGAVGIECRLDDS 210 SR LP ++ +PAV QG +G++CR D+ Sbjct: 504 AMLAPSPSATPSPCPAPSPNETSRGTEPGGCVEAVLLPADVFVPAVCQGIIGVQCRSADT 563 Query: 211 RTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELI 253 LL LN + + ERA L+G C+ PI AE Sbjct: 564 GILSLLRELNSPSSRGQALCERAFLRALDGSCRTPIAGIAEWR 606 Score = 119 bits (299), Expect = 1e-25, Method: Composition-based stats. Identities = 44/96 (45%), Positives = 56/96 (58%), Gaps = 3/96 (3%) Query: 23 VKDKLMASHPGLVV---ELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAV 79 V L+ L +VPM T GD L PLA+VGGKGLF KEL++ALL + D+ V Sbjct: 253 VLASLLRVDSRLEYGELRIVPMQTTGDKELHLPLAQVGGKGLFTKELDLALLHGQVDVVV 312 Query: 80 HSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS 115 HS+KDVP E P+G + REDPRDA + + Sbjct: 313 HSLKDVPTELPEGTEIGAYLPREDPRDALIFSRKPR 348 Score = 52.8 bits (126), Expect = 1e-05, Method: Composition-based stats. Identities = 18/67 (26%), Positives = 32/67 (47%), Gaps = 5/67 (7%) Query: 247 GSYAELIDGEI-WLRALVGAPDGSQIIRGERRG----APQDAEQMGISLAEELLNNGARE 301 G A ++ ++ PDG Q+ R ER P++AE +G ++AEE+ + Sbjct: 669 GVLATPDGKQLLRFCGVLATPDGKQLFREERTVRGVRTPEEAEALGRAVAEEIKKAAGAD 728 Query: 302 ILAEVYN 308 LA++ Sbjct: 729 RLAQIKK 735 Score = 43.9 bits (103), Expect = 0.007, Method: Composition-based stats. Identities = 12/31 (38%), Positives = 15/31 (48%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPG 33 LR+ +R SPLAL QA +L P Sbjct: 160 KTPLRVGSRASPLALAQARQFVYRLALRFPD 190 >UniRef50_Q401C3 Hydroxymethylbilane synthase (Fragment) n=7 Tax=Coelomata RepID=Q401C3_CAPHI Length = 109 Score = 133 bits (335), Expect = 9e-30, Method: Composition-based stats. Identities = 44/93 (47%), Positives = 59/93 (63%), Gaps = 4/93 (4%) Query: 104 PRDAFVSNN---YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD 160 P +A V + +L+ LP S+VGTSSLRR QL + P L R++RGN+ TRL KLD Sbjct: 17 PMNAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRNIRGNLNTRLRKLD 76 Query: 161 N-GEYDAIILAVAGLKRLGLESRIRAALPPEIS 192 E+ AIILA AGL+R+G ++R+ L PE Sbjct: 77 ELQEFSAIILAAAGLQRMGWQNRVGQILHPEEC 109 >UniRef50_UPI0001742E92 Porphobilinogen deaminase n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI0001742E92 Length = 119 Score = 129 bits (324), Expect = 2e-28, Method: Composition-based stats. Identities = 32/115 (27%), Positives = 60/115 (52%), Gaps = 2/115 (1%) Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 + + +PA GQG + I+CR +D++ R LL +N E + AER + +GGC Sbjct: 1 MSEYFDTDFFMPAPGQGILCIQCRENDNKIRHLLEIINDDEVTMMCEAEREFSKIFDGGC 60 Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 PIG + + + L+ + +GS++++ E G ++ +++ LAEE+ Sbjct: 61 HTPIGCSSVIEGDTLKLKGM-FNDNGSRMLK-EVEGNKENPKEIAQKLAEEIKKE 113 >UniRef50_C4Z1K5 Putative uncharacterized protein n=1 Tax=Eubacterium eligens ATCC 27750 RepID=C4Z1K5_EUBE2 Length = 287 Score = 122 bits (308), Expect = 1e-26, Method: Composition-based stats. Identities = 48/242 (19%), Positives = 96/242 (39%), Gaps = 34/242 (14%) Query: 55 KVGGKGLFVKELEVALLENRADIAVHSMKDVPV---------EFPQGLGLVTICEREDPR 105 ++GG ++ LE AL+++ D+ + D+ + + G+ + + +R DPR Sbjct: 42 EIGGSDIY-PALE-ALIDDNIDMV---LVDMRMLVEMEKSGQQLDDGIVISGVIKRRDPR 96 Query: 106 DAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYD 165 + + ++V T S + E ++ + N+ +SKLD+ E D Sbjct: 97 YVMIRRRGT--KDVVENAVVVTDSDENAAVICEMYDNVECV-VENNIKDCMSKLDSEECD 153 Query: 166 AIILAV---AGLKRL--GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALN 220 A + A + RL GL+ + + +P GQG I S + + ++ Sbjct: 154 A-VFAFYDDIRIARLYNGLKYKYT-LMDFSDCVPPHGQGIYCILTNGKRSVIKHMFD-VS 210 Query: 221 HHETALRVTAERAMNTRLEG-----GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE 275 H TA+ E + RL C +Y ++ +I + A V G+ ++ + Sbjct: 211 HRTTAMSFDIEEDIIRRLLMNDYVKSCN----AYVKISGDKIEVYADVKGYRGNIKVQEK 266 Query: 276 RR 277 Sbjct: 267 DE 268 >UniRef50_Q1HRH6 Hydroxymethylbilane synthase-like protein n=1 Tax=Aedes aegypti RepID=Q1HRH6_AEDAE Length = 349 Score = 116 bits (291), Expect = 1e-24, Method: Composition-based stats. Identities = 34/111 (30%), Positives = 52/111 (46%), Gaps = 6/111 (5%) Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236 +G E RI + P L AVGQGA+ +ECR +D +L+ L H ET ++ ER+ Sbjct: 1 MGWEKRIDQVIEPSEILYAVGQGALAVECRSNDEYILNMLSKLCHLETQCKILVERSFLK 60 Query: 237 RLEGGCQVPIGSYAEL------IDGEIWLRALVGAPDGSQIIRGERRGAPQ 281 L GGC P+ L + ++ V + DG IR + + + Sbjct: 61 TLGGGCSAPVAVCTSLKRKHDSKSNYLNIQGAVWSLDGKTEIRADDGCSVE 111 >UniRef50_UPI0001698669 porphobilinogen deaminase n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2' RepID=UPI0001698669 Length = 136 Score = 116 bits (291), Expect = 1e-24, Method: Composition-based stats. Identities = 64/135 (47%), Positives = 79/135 (58%), Gaps = 11/135 (8%) Query: 170 AVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVT 229 AGLKRLG E RI A + PE SLPA+GQGA+GIECR DD++ L+A L+H +TA V Sbjct: 6 PSAGLKRLGFEQRITAFIAPEQSLPAIGQGAIGIECRSDDAQVNALIAPLHHVDTAACVH 65 Query: 230 AERAMNTRLEGG-----CQVP-IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDA 283 AERAMN RL GG C++ G A W R+ V + GE G P +A Sbjct: 66 AERAMNNRLMGGSPCADCRLRDAGVPATSGCVVWWARSTVA-----RSCVGEAEGTPDEA 120 Query: 284 EQMGISLAEELLNNG 298 E +G+ LAE LL G Sbjct: 121 ESLGVGLAERLLELG 135 >UniRef50_C5G109 Porphobilinogen deaminase n=1 Tax=Microsporum canis CBS 113480 RepID=C5G109_NANOT Length = 282 Score = 110 bits (275), Expect = 8e-23, Method: Composition-based stats. Identities = 54/233 (23%), Positives = 81/233 (34%), Gaps = 48/233 (20%) Query: 84 DVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDL 143 DV + P I + Y SL LP G+I+ TS +R QL P L Sbjct: 93 DVSTKLPDSCDPAAIPVKA-------GLPYTSLQTLPEGAIIATSLVRPSAQLRRLFPTL 145 Query: 144 IIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGI 203 ++RGNV + + + A LG P QG Sbjct: 146 RFANVRGNVES------------LTIPQA----LGTVGSSTRGRPRARRR--RHQGY--- 184 Query: 204 ECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALV 263 + + + L AL + L L GC PIG E + +RA+V Sbjct: 185 ----SSAGSADRLLAL---PSVLMC--------ALRSGCNAPIGIETEWTATHLSIRAIV 229 Query: 264 GAPDGSQIIRGERRG---APQDAEQMGISLAEELLNNGAREILAEVYNGDAPA 313 + D SQ + +++ G +LA L G IL ++ N + P+ Sbjct: 230 VSLDISQSVEDAIDAMMHTKDESDAPGQALAR-LFGAGVAPILIDI-NRNQPS 280 >UniRef50_UPI0000D537E6 hypothetical protein P700755_22735 n=1 Tax=Psychroflexus torquis ATCC 700755 RepID=UPI0000D537E6 Length = 356 Score = 104 bits (259), Expect = 6e-21, Method: Composition-based stats. Identities = 46/241 (19%), Positives = 83/241 (34%), Gaps = 38/241 (15%) Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127 +L + D+ S D + +GL + + R++P V+N+ + L G+ + Sbjct: 49 QSLRDGAGDLVAMSAFDWQQQDVEGLIIAGLLTRKEPTWVLVANDKP--EYLKQGAYILC 106 Query: 128 S--SLRRQCQLAERRPDLIIRSL-----RGNVGTRLSKLDN-------------GEYDAI 167 LRR Q+ R DL + ++ R N +S+LD G D Sbjct: 107 DHELLRR--QMMRLRGDLTLETMEEMGKRLNAAATISELDEEDIWPWVEGLLKNGNIDGF 164 Query: 168 ILAVA--GLKR-------LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAA 218 I+ A R LGL+ + E +P G + R + + Sbjct: 165 IVPRAIHASHRMKSRRHTLGLQRDNSES-NRERFIPPPLHGFTMLVGRNGFPKAS--IQD 221 Query: 219 LNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRG 278 + L E A+ LE + +G++ E +I + DG + + Sbjct: 222 MVDQSAELAYRLEAAILESLEPSLRPIVGAFVEQR--KIATILKKASEDGDEALLNTLVD 279 Query: 279 A 279 Sbjct: 280 P 280 >UniRef50_UPI0000D9FBB5 PREDICTED: similar to lethal (3) 02640 CG9165-PA n=1 Tax=Macaca mulatta RepID=UPI0000D9FBB5 Length = 105 Score = 100 bits (249), Expect = 8e-20, Method: Composition-based stats. Identities = 34/113 (30%), Positives = 45/113 (39%), Gaps = 17/113 (15%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + LRI +R+S LA Q V D+L G V LV M G+ Sbjct: 5 SNATLRIGSRRSDLARLQTLMVADRLEEM--GYKVVLVGM---------------PETGV 47 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD 114 F L LL+ D+ VHS KD+P+ G + R DPRD + Sbjct: 48 FTTFLRQKLLDGSVDLVVHSWKDLPLAEEAGTTVAATLPRADPRDLIIIRKDA 100 >UniRef50_B8N6H4 Putative uncharacterized protein n=1 Tax=Aspergillus flavus NRRL3357 RepID=B8N6H4_ASPFN Length = 90 Score = 99.0 bits (246), Expect = 2e-19, Method: Composition-based stats. Identities = 30/79 (37%), Positives = 40/79 (50%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR+S LA+ QA +++ L PG E+ + T GD T L G K L+ Sbjct: 10 PLRIGTRRSNLAMVQAEGIRNCLQKIAPGRSFEIEALRTLGDRDQLTALYNFGAKSLWTT 69 Query: 65 ELEVALLENRADIAVHSMK 83 ELE L D+ VH +K Sbjct: 70 ELEEKLNAGELDVIVHCLK 88 >UniRef50_UPI0001C35DE1 porphobilinogen deaminase n=1 Tax=Clostridium hathewayi DSM 13479 RepID=UPI0001C35DE1 Length = 121 Score = 88.2 bits (218), Expect = 4e-16, Method: Composition-based stats. Identities = 25/112 (22%), Positives = 47/112 (41%), Gaps = 3/112 (2%) Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 E +PA GQG + +E R++D R E+ + + + ER + L+ GC Sbjct: 13 FHYFACEAFIPAGGQGILAVEGRIED-RICEMAVRIQDEDAKTCLMLERKILKLLDAGCH 71 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295 P+G Y+ + EI + + + + R G + + + A+ L Sbjct: 72 EPVGVYSRIRGEEIEVFGI--SRRDRETKRVYLTGGIGELDLLAERAAKGLR 121 >UniRef50_C5U771 Porphobilinogen deaminase n=1 Tax=Methanocaldococcus infernus ME RepID=C5U771_9EURY Length = 89 Score = 74.7 bits (183), Expect = 4e-12, Method: Composition-based stats. Identities = 24/83 (28%), Positives = 34/83 (40%), Gaps = 3/83 (3%) Query: 217 AALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER 276 +N +T L TAER L GC VP G++A+ + L+ V D Sbjct: 2 EKINDKKTFLETTAERKALNELGCGCHVPFGAFAKYEGKRLMLKVAVANKDRVIKKESSI 61 Query: 277 RGAPQD---AEQMGISLAEELLN 296 + AE++G SL EL Sbjct: 62 CCEVDEIEKAEKLGESLGRELRR 84 >UniRef50_Q4EB45 Porphobilinogen deaminase n=1 Tax=Wolbachia endosymbiont of Drosophila ananassae RepID=Q4EB45_9RICK Length = 62 Score = 62.4 bits (151), Expect = 2e-08, Method: Composition-based stats. Identities = 20/50 (40%), Positives = 30/50 (60%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAK 55 ++I TR S LA+ QA K KL+ S P L +E+V + + GD + LA+ Sbjct: 13 VKIGTRGSKLAVVQALEAKQKLLDSFPNLSIEIVKIKSSGDKYANANLAE 62 >UniRef50_B5XH53 Porphobilinogen deaminase n=1 Tax=Salmo salar RepID=B5XH53_SALSA Length = 55 Score = 59.7 bits (144), Expect = 1e-07, Method: Composition-based stats. Identities = 15/39 (38%), Positives = 22/39 (56%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPM 41 V+RI TR S LA Q V +KL +P + +E+V + Sbjct: 16 SRVIRIGTRNSQLARIQTDSVAEKLKGLYPDVHIEIVGI 54 >UniRef50_C2BR76 Putative uncharacterized protein (Fragment) n=1 Tax=Corynebacterium pseudogenitalium ATCC 33035 RepID=C2BR76_9CORY Length = 62 Score = 56.2 bits (135), Expect = 2e-06, Method: Composition-based stats. Identities = 16/62 (25%), Positives = 32/62 (51%) Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 P+ + + ++ +R V A DGS+ + G+ +A +G +++EL GA E+L Sbjct: 1 APVAATSRWDGDQLTVRGGVFALDGSRQLTATASGSAAEAADLGARISDELFAGGAAELL 60 Query: 304 AE 305 + Sbjct: 61 GK 62 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.313 0.173 0.546 Lambda K H 0.267 0.0529 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 1,846,002,234 Number of Sequences: 3077464 Number of extensions: 111957290 Number of successful extensions: 266328 Number of sequences better than 1.0e-01: 231 Number of HSP's better than 0.1 without gapping: 459 Number of HSP's successfully gapped in prelim test: 3 Number of HSP's that attempted gapping in prelim test: 264544 Number of HSP's gapped (non-prelim): 541 length of query: 313 length of database: 1,040,396,356 effective HSP length: 128 effective length of query: 185 effective length of database: 646,480,964 effective search space: 119598978340 effective search space used: 119598978340 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.0 bits) S2: 94 (40.4 bits)