BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (313 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_B7LU53 Porphobilinogen deaminase n=87 Tax=cellular orga... 593 e-168 UniRef50_B5FN93 Porphobilinogen deaminase n=168 Tax=cellular org... 566 e-160 UniRef50_Q0I178 Porphobilinogen deaminase n=45 Tax=Bacteria RepI... 387 e-106 UniRef50_C0QU69 Porphobilinogen deaminase n=4 Tax=Bacteria RepID... 365 1e-99 UniRef50_B5YJZ4 Porphobilinogen deaminase n=2 Tax=Bacteria RepID... 322 1e-86 UniRef50_A1AUE7 Porphobilinogen deaminase n=44 Tax=Bacteria RepI... 307 2e-82 UniRef50_B5EBG8 Porphobilinogen deaminase n=166 Tax=Bacteria Rep... 306 6e-82 UniRef50_Q30Y29 Porphobilinogen deaminase n=13 Tax=Bacteria RepI... 305 2e-81 UniRef50_A7GYU4 Porphobilinogen deaminase n=34 Tax=Campylobacter... 301 2e-80 UniRef50_Q5ZRY6 Porphobilinogen deaminase n=6 Tax=Legionella Rep... 296 7e-79 UniRef50_B3E2H7 Porphobilinogen deaminase n=3 Tax=Proteobacteria... 293 4e-78 UniRef50_C9KL85 Hydroxymethylbilane synthase n=1 Tax=Mitsuokella... 293 6e-78 UniRef50_C6HUG2 Porphobilinogen deaminase n=1 Tax=Leptospirillum... 292 1e-77 UniRef50_Q8YVU6 Porphobilinogen deaminase n=50 Tax=cellular orga... 291 3e-77 UniRef50_Q3ACT3 Porphobilinogen deaminase n=2 Tax=Bacteria RepID... 288 2e-76 UniRef50_D0LUE1 Porphobilinogen deaminase n=1 Tax=Haliangium och... 286 6e-76 UniRef50_Q8DIE4 Porphobilinogen deaminase n=11 Tax=cellular orga... 285 1e-75 UniRef50_D1BNZ5 Porphobilinogen deaminase n=3 Tax=Veillonella Re... 276 7e-73 UniRef50_A9FDP9 Porphobilinogen deaminase n=1 Tax=Sorangium cell... 276 8e-73 UniRef50_A7NKU8 Porphobilinogen deaminase n=5 Tax=Bacteria RepID... 275 1e-72 UniRef50_Q31PM2 Porphobilinogen deaminase n=8 Tax=cellular organ... 275 1e-72 UniRef50_Q4HT06 Porphobilinogen deaminase n=1 Tax=Campylobacter ... 275 2e-72 UniRef50_C0Q9U2 HemC n=2 Tax=Bacteria RepID=C0Q9U2_DESAH 275 2e-72 UniRef50_B3QWI1 Porphobilinogen deaminase n=12 Tax=Chlorobiaceae... 273 7e-72 UniRef50_A3MLK5 Porphobilinogen deaminase n=155 Tax=Proteobacter... 270 4e-71 UniRef50_Q8D2W2 HemC protein n=1 Tax=Wigglesworthia glossinidia ... 268 3e-70 UniRef50_A6TJD5 Porphobilinogen deaminase n=2 Tax=Firmicutes Rep... 264 3e-69 UniRef50_Q2RJ26 Porphobilinogen deaminase n=5 Tax=Clostridia Rep... 263 5e-69 UniRef50_A8PKX6 Porphobilinogen deaminase n=2 Tax=Gammaproteobac... 262 1e-68 UniRef50_D2R3S6 Porphobilinogen deaminase n=2 Tax=Planctomycetac... 258 2e-67 UniRef50_A3ETN3 Porphobilinogen deaminase n=2 Tax=Leptospirillum... 256 5e-67 UniRef50_C8WXM9 Porphobilinogen deaminase n=2 Tax=Alicyclobacill... 256 8e-67 UniRef50_A8LIJ6 Porphobilinogen deaminase n=11 Tax=Alphaproteoba... 254 2e-66 UniRef50_Q65GK1 Porphobilinogen deaminase n=98 Tax=Bacillales Re... 254 3e-66 UniRef50_A6Q7Y4 Porphobilinogen deaminase n=7 Tax=Epsilonproteob... 253 6e-66 UniRef50_C9R7U0 Porphobilinogen deaminase n=1 Tax=Ammonifex dege... 249 6e-65 UniRef50_B2A1G7 Porphobilinogen deaminase n=1 Tax=Natranaerobius... 249 6e-65 UniRef50_Q4L709 Porphobilinogen deaminase n=88 Tax=Bacillales Re... 249 1e-64 UniRef50_Q43316 Porphobilinogen deaminase, chloroplastic n=61 Ta... 248 2e-64 UniRef50_Q2S2A6 Porphobilinogen deaminase n=1 Tax=Salinibacter r... 248 2e-64 UniRef50_P08397 Porphobilinogen deaminase n=59 Tax=Chordata RepI... 244 2e-63 UniRef50_C3XEZ5 Porphobilinogen deaminase n=3 Tax=Campylobactera... 244 3e-63 UniRef50_Q2LQU2 Porphobilinogen deaminase n=1 Tax=Syntrophus aci... 244 4e-63 UniRef50_Q54P93 Porphobilinogen deaminase n=1 Tax=Dictyostelium ... 240 4e-62 UniRef50_B2S842 Porphobilinogen deaminase n=38 Tax=Rhizobiales R... 236 7e-61 UniRef50_A6WXJ2 Porphobilinogen deaminase n=56 Tax=cellular orga... 236 8e-61 UniRef50_A6GB01 Porphobilinogen deaminase n=2 Tax=Bacteria RepID... 231 3e-59 UniRef50_A3ZKX4 Porphobilinogen deaminase n=1 Tax=Blastopirellul... 231 4e-59 UniRef50_C8WIZ2 Porphobilinogen deaminase n=2 Tax=Coriobacteriac... 230 5e-59 UniRef50_UPI0000583C22 PREDICTED: hypothetical protein n=1 Tax=S... 229 1e-58 UniRef50_A7BMK1 Porphobilinogen deaminase n=1 Tax=Beggiatoa sp. ... 228 2e-58 UniRef50_C1ZK04 Porphobilinogen deaminase n=1 Tax=Planctomyces l... 228 2e-58 UniRef50_C1AA38 Porphobilinogen deaminase n=1 Tax=Gemmatimonas a... 227 4e-58 UniRef50_UPI00017922DC PREDICTED: similar to porphobilinogen dea... 225 1e-57 UniRef50_Q1J288 Porphobilinogen deaminase n=5 Tax=Deinococci Rep... 224 4e-57 UniRef50_A8U3E9 Porphobilinogen deaminase n=1 Tax=alpha proteoba... 222 1e-56 UniRef50_A6DBT5 Porphobilinogen deaminase n=1 Tax=Caminibacter m... 222 1e-56 UniRef50_A3CL78 Porphobilinogen deaminase n=1 Tax=Streptococcus ... 219 7e-56 UniRef50_C1F251 Hydroxymethylbilane synthase n=1 Tax=Acidobacter... 219 7e-56 UniRef50_O94048 Porphobilinogen deaminase n=53 Tax=Saccharomycet... 217 5e-55 UniRef50_C7NFP7 Hydroxymethylbilane synthase n=7 Tax=Actinomycet... 215 1e-54 UniRef50_Q0TQG4 Porphobilinogen deaminase n=32 Tax=Clostridium R... 214 3e-54 UniRef50_Q3YSA8 Porphobilinogen deaminase n=17 Tax=Rickettsiales... 214 4e-54 UniRef50_B6FXV9 Putative uncharacterized protein n=1 Tax=Clostri... 212 1e-53 UniRef50_C3PNS9 Porphobilinogen deaminase n=15 Tax=Rickettsia Re... 212 1e-53 UniRef50_Q180R9 Porphobilinogen deaminase n=11 Tax=Bacteria RepI... 212 1e-53 UniRef50_A3VPD5 Porphobilinogen deaminase n=1 Tax=Parvularcula b... 211 2e-53 UniRef50_Q5HBG1 Porphobilinogen deaminase n=2 Tax=Ehrlichia rumi... 211 2e-53 UniRef50_B3U3W9 Hydroxymethylbilane synthetase n=1 Tax=Oxyrrhis ... 209 7e-53 UniRef50_A8MDU3 Probable porphobilinogen deaminase n=2 Tax=Therm... 209 7e-53 UniRef50_C4Z552 Porphobilinogen deaminase n=8 Tax=Bacteria RepID... 209 1e-52 UniRef50_A5CDH4 Porphobilinogen deaminase n=2 Tax=Orientia tsuts... 208 2e-52 UniRef50_Q1EPC8 Porphobilinogen deaminase, chloroplast (Hydroxym... 207 5e-52 UniRef50_C1CYD9 Porphobilinogen deaminase n=3 Tax=Deinococci Rep... 207 5e-52 UniRef50_B8GXG1 Porphobilinogen deaminase n=8 Tax=Caulobacterace... 205 1e-51 UniRef50_Q8TXC8 Probable porphobilinogen deaminase n=1 Tax=Metha... 205 1e-51 UniRef50_B2IAW6 Porphobilinogen deaminase n=4 Tax=Alphaproteobac... 205 1e-51 UniRef50_Q11XT5 Porphobilinogen deaminase n=8 Tax=Bacteria RepID... 204 3e-51 UniRef50_A2BL26 Probable porphobilinogen deaminase n=2 Tax=Therm... 204 4e-51 UniRef50_B3T8H9 Putative Porphobilinogen deaminase, dipyromethan... 204 4e-51 UniRef50_B0K2L4 Porphobilinogen deaminase n=7 Tax=Bacteria RepID... 204 4e-51 UniRef50_A0QLI0 Porphobilinogen deaminase n=69 Tax=Actinomycetal... 204 4e-51 UniRef50_D1CBT4 Porphobilinogen deaminase n=1 Tax=Thermobaculum ... 202 1e-50 UniRef50_A6GVP0 Hydroxymethylbilane synthase n=18 Tax=Bacteroide... 202 1e-50 UniRef50_A0LRF1 Porphobilinogen deaminase n=1 Tax=Acidothermus c... 201 2e-50 UniRef50_A9A1A1 Probable porphobilinogen deaminase n=3 Tax=Thaum... 201 2e-50 UniRef50_C6WZF5 Porphobilinogen deaminase n=1 Tax=Flavobacteriac... 201 3e-50 UniRef50_Q1V167 Hydroxymethylbilane synthase n=3 Tax=Candidatus ... 201 3e-50 UniRef50_A2Q9P7 Catalytic activity: 4 porphobilinogen+H(2)O<=>hy... 201 4e-50 UniRef50_Q9F7M2 Predicted porphobilinogen deaminase n=2 Tax=Bact... 200 4e-50 UniRef50_C7N5L0 Porphobilinogen deaminase n=2 Tax=Slackia RepID=... 200 5e-50 UniRef50_Q0BX92 Porphobilinogen deaminase n=1 Tax=Hyphomonas nep... 199 8e-50 UniRef50_A5VM67 Porphobilinogen deaminase n=9 Tax=Lactobacillus ... 199 8e-50 UniRef50_Q47LA7 Porphobilinogen deaminase n=3 Tax=Actinomycetale... 199 9e-50 UniRef50_C0YV01 Hydroxymethylbilane synthase n=1 Tax=Chryseobact... 199 1e-49 UniRef50_D0NJW2 Porphobilinogen deaminase n=2 Tax=Phytophthora i... 199 1e-49 UniRef50_Q82P95 Porphobilinogen deaminase 2 n=14 Tax=Actinomycet... 199 1e-49 UniRef50_C6R3Y0 Hydroxymethylbilane synthase n=1 Tax=Rothia muci... 198 2e-49 UniRef50_Q8RFP5 Porphobilinogen deaminase n=16 Tax=Fusobacteriac... 198 2e-49 UniRef50_C9RPT6 Porphobilinogen deaminase n=1 Tax=Fibrobacter su... 198 3e-49 UniRef50_A4CHM3 Porphobilinogen deaminase n=4 Tax=Bacteroidetes ... 197 3e-49 UniRef50_D2NS36 Porphobilinogen deaminase n=2 Tax=Micrococcaceae... 197 4e-49 UniRef50_Q7UPN0 Porphobilinogen deaminase n=1 Tax=Rhodopirellula... 197 4e-49 UniRef50_B5G8F1 Porphobilinogen deaminase n=1 Tax=Streptomyces s... 196 8e-49 UniRef50_C6XGK7 Porphobilinogen deaminase n=1 Tax=Candidatus Lib... 196 9e-49 UniRef50_UPI0001926E0E PREDICTED: similar to hydroxymethylbilane... 196 1e-48 UniRef50_C3WGN0 Porphobilinogen deaminase n=5 Tax=Fusobacterium ... 196 1e-48 UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia... 195 1e-48 UniRef50_C6XST0 Porphobilinogen deaminase n=2 Tax=Pedobacter Rep... 194 3e-48 UniRef50_C5RMN3 Porphobilinogen deaminase n=1 Tax=Clostridium ce... 194 3e-48 UniRef50_P28789 Porphobilinogen deaminase n=18 Tax=Saccharomycet... 194 3e-48 UniRef50_Q09899 Porphobilinogen deaminase n=2 Tax=Schizosaccharo... 192 1e-47 UniRef50_A0DD68 Chromosome undetermined scaffold_46, whole genom... 192 2e-47 UniRef50_A8MGE4 Porphobilinogen deaminase n=30 Tax=cellular orga... 191 3e-47 UniRef50_C0BZ93 Putative uncharacterized protein n=1 Tax=Clostri... 191 3e-47 UniRef50_Q1AUK3 Porphobilinogen deaminase n=1 Tax=Rubrobacter xy... 191 3e-47 UniRef50_C1TM53 Porphobilinogen deaminase n=1 Tax=Dethiosulfovib... 191 3e-47 UniRef50_B3RTQ8 Putative uncharacterized protein n=1 Tax=Trichop... 191 4e-47 UniRef50_B0D5Q2 Predicted protein n=1 Tax=Laccaria bicolor S238N... 190 5e-47 UniRef50_C4QMG7 Hydroxymethylbilane synthase (Porphobilinogen de... 189 1e-46 UniRef50_D1BFI8 Hydroxymethylbilane synthase n=4 Tax=Actinomycet... 189 1e-46 UniRef50_Q4T5L1 Chromosome undetermined SCAF9206, whole genome s... 189 1e-46 UniRef50_UPI00006CBE06 porphobilinogen deaminase family protein ... 188 2e-46 UniRef50_B8MVK7 Porphobilinogen deaminase, putative n=1 Tax=Tala... 187 4e-46 UniRef50_B9XN63 Porphobilinogen deaminase n=1 Tax=bacterium Elli... 187 4e-46 UniRef50_C4ZFT9 Porphobilinogen deaminase n=1 Tax=Eubacterium re... 186 8e-46 UniRef50_Q0ATQ1 Porphobilinogen deaminase n=3 Tax=Alphaproteobac... 186 1e-45 UniRef50_Q4PFH9 Putative uncharacterized protein n=1 Tax=Ustilag... 186 1e-45 UniRef50_C9M5W1 Hydroxymethylbilane synthase n=1 Tax=Jonquetella... 186 1e-45 UniRef50_C5EV71 Pyruvate ferredoxin/flavodoxin oxidoreductase n=... 185 2e-45 UniRef50_Q93A65 Porphobilinogen deaminase n=1 Tax=uncultured bac... 185 2e-45 UniRef50_A8PWJ5 Putative uncharacterized protein n=1 Tax=Malasse... 185 2e-45 UniRef50_Q6L2G8 Probable porphobilinogen deaminase n=1 Tax=Picro... 185 2e-45 UniRef50_A2BFN7 Hydroxymethylbilane synthase (Fragment) n=6 Tax=... 185 2e-45 UniRef50_O29026 Probable porphobilinogen deaminase n=1 Tax=Archa... 184 3e-45 UniRef50_B2W5W6 Porphobilinogen deaminase n=2 Tax=Pleosporineae ... 184 4e-45 UniRef50_A9HK97 Porphobilinogen deaminase n=12 Tax=Acetobacterac... 183 8e-45 UniRef50_C1XV35 Porphobilinogen deaminase n=2 Tax=Meiothermus Re... 182 2e-44 UniRef50_A4QB59 Porphobilinogen deaminase n=15 Tax=Corynebacteri... 181 3e-44 UniRef50_C6V4N6 Porphobilinogen deaminase n=2 Tax=Neorickettsia ... 181 4e-44 UniRef50_A8SQW4 Putative uncharacterized protein n=1 Tax=Coproco... 180 6e-44 UniRef50_C7M2H5 Porphobilinogen deaminase n=1 Tax=Acidimicrobium... 179 8e-44 UniRef50_B3DZQ6 Porphobilinogen deaminase n=1 Tax=Methylacidiphi... 179 1e-43 UniRef50_C5CB88 Porphobilinogen deaminase n=5 Tax=Actinomycetale... 179 1e-43 UniRef50_C7DH16 Porphobilinogen deaminase n=1 Tax=Candidatus Mic... 179 1e-43 UniRef50_D2RH82 Porphobilinogen deaminase n=2 Tax=Archaeoglobace... 179 1e-43 UniRef50_B4D5X7 Porphobilinogen deaminase n=1 Tax=Chthoniobacter... 179 2e-43 UniRef50_UPI000174444E Hydroxymethylbilane synthase n=1 Tax=Verr... 176 1e-42 UniRef50_Q1GP41 Porphobilinogen deaminase n=7 Tax=Sphingomonadal... 176 1e-42 UniRef50_UPI0001BC2D4C glutamyl-tRNA reductase n=1 Tax=Brevibact... 176 1e-42 UniRef50_A4XK06 Porphobilinogen deaminase n=2 Tax=Clostridia Rep... 175 2e-42 UniRef50_C6XKH7 Porphobilinogen deaminase n=1 Tax=Hirschia balti... 175 2e-42 UniRef50_C7R376 Porphobilinogen deaminase n=1 Tax=Jonesia denitr... 174 3e-42 UniRef50_D2RNT2 Porphobilinogen deaminase n=1 Tax=Acidaminococcu... 174 3e-42 UniRef50_Q46CH0 Probable porphobilinogen deaminase n=7 Tax=Eurya... 174 4e-42 UniRef50_C2GGB5 Porphobilinogen deaminase n=2 Tax=Corynebacteriu... 172 1e-41 UniRef50_C8WDJ7 Porphobilinogen deaminase n=3 Tax=Zymomonas mobi... 172 2e-41 UniRef50_C2FZW8 Porphobilinogen deaminase n=2 Tax=Sphingobacteri... 170 6e-41 UniRef50_A8AAB4 Probable porphobilinogen deaminase n=1 Tax=Ignic... 169 1e-40 UniRef50_D1VCA1 Porphobilinogen deaminase n=1 Tax=Frankia sp. Eu... 169 1e-40 UniRef50_UPI0001C31A39 porphobilinogen deaminase n=1 Tax=Conexib... 169 1e-40 UniRef50_A9V9E0 Predicted protein n=1 Tax=Monosiga brevicollis R... 168 2e-40 UniRef50_B5JN62 Porphobilinogen deaminase n=1 Tax=Verrucomicrobi... 168 2e-40 UniRef50_D1C4S0 Porphobilinogen deaminase n=1 Tax=Sphaerobacter ... 167 5e-40 UniRef50_B6W7F3 Putative uncharacterized protein n=1 Tax=Anaeroc... 167 5e-40 UniRef50_Q6AHF1 Porphobilinogen deaminase n=5 Tax=Actinobacteria... 166 8e-40 UniRef50_C5C5B3 Porphobilinogen deaminase n=6 Tax=Actinomycetale... 166 1e-39 UniRef50_A6LKX0 Porphobilinogen deaminase n=1 Tax=Thermosipho me... 164 4e-39 UniRef50_Q5KKQ0 Hydroxymethylbilane synthase, putative n=2 Tax=F... 164 4e-39 UniRef50_A4WN24 Probable porphobilinogen deaminase n=3 Tax=Therm... 164 5e-39 UniRef50_B2ULP1 Porphobilinogen deaminase n=1 Tax=Akkermansia mu... 163 6e-39 UniRef50_B0WMK9 Porphobilinogen deaminase n=1 Tax=Culex quinquef... 162 1e-38 UniRef50_B3LB83 Porphobilinogen deaminase, putative n=1 Tax=Plas... 162 1e-38 UniRef50_Q57989 Probable porphobilinogen deaminase n=11 Tax=Meth... 159 1e-37 UniRef50_Q2FTK7 Hydroxymethylbilane synthase n=3 Tax=Methanomicr... 158 2e-37 UniRef50_O26960 Probable porphobilinogen deaminase n=1 Tax=Metha... 158 3e-37 UniRef50_A4YD92 Probable porphobilinogen deaminase n=1 Tax=Metal... 158 3e-37 UniRef50_A1DGB8 Porphobilinogen deaminase n=1 Tax=Neosartorya fi... 156 8e-37 UniRef50_D1B7N1 Porphobilinogen deaminase n=1 Tax=Thermanaerovib... 156 8e-37 UniRef50_A2SQU4 Uroporphyrin-III C-methyltransferase n=11 Tax=Eu... 154 3e-36 UniRef50_Q8I5V3 Porphobilinogen deaminase n=6 Tax=Plasmodium Rep... 154 3e-36 UniRef50_Q2NEP4 HemC n=4 Tax=Methanobacteriaceae RepID=Q2NEP4_METST 153 7e-36 UniRef50_D0J8N1 Porphobilinogen deaminase n=2 Tax=Blattabacteriu... 153 8e-36 UniRef50_B5GJG2 Porphobilinogen deaminase n=3 Tax=Streptomyces R... 153 9e-36 UniRef50_C0W553 Porphobilinogen deaminase n=2 Tax=Actinomycetale... 151 3e-35 UniRef50_C4JRY9 Porphobilinogen deaminase n=1 Tax=Uncinocarpus r... 151 4e-35 UniRef50_B6JII8 Porphobilinogen deaminase n=11 Tax=Bradyrhizobia... 150 6e-35 UniRef50_D1JID7 Porphobilinogen deaminase n=1 Tax=uncultured arc... 149 1e-34 UniRef50_A5K0J5 Porphobilinogen deaminase, putative n=1 Tax=Plas... 148 3e-34 UniRef50_Q4E9D5 Porphobilinogen deaminase (Fragment) n=1 Tax=Wol... 147 6e-34 UniRef50_C3MZR8 Probable porphobilinogen deaminase n=11 Tax=Sulf... 145 2e-33 UniRef50_UPI000038E213 porphobilinogen deaminase n=1 Tax=Ferropl... 142 1e-32 UniRef50_Q9Y9J0 Probable porphobilinogen deaminase n=1 Tax=Aerop... 142 2e-32 UniRef50_Q86ET2 Clone ZZD1450 mRNA sequence n=3 Tax=Schistosoma ... 137 4e-31 UniRef50_Q97B26 Probable porphobilinogen deaminase n=2 Tax=Therm... 135 2e-30 UniRef50_Q0RS16 Porphobilinogen deaminase 1 (PBG 1) (Hydroxymeth... 133 8e-30 UniRef50_Q83H95 Porphobilinogen deaminase n=2 Tax=Tropheryma whi... 131 3e-29 UniRef50_B6YQR9 Hydroxymethylbilane synthase/uroporphyrin-III C-... 130 4e-29 UniRef50_B4UXX3 Porphobilinogen deaminase 2 (Fragment) n=1 Tax=S... 130 9e-29 UniRef50_B1ZV87 Porphobilinogen deaminase n=2 Tax=Opitutaceae Re... 129 9e-29 UniRef50_Q04X38 Bifunctional porphobilinogen deaminase/uroporphy... 129 2e-28 UniRef50_Q9HMY5 Probable porphobilinogen deaminase n=2 Tax=Halob... 127 6e-28 UniRef50_A8I2X7 Porphobilinogen deaminase n=1 Tax=Chlamydomonas ... 118 3e-25 UniRef50_Q18ES3 Hydroxymethylbilane synthase (Porphobilinogen de... 114 3e-24 UniRef50_Q9PK95 Probable porphobilinogen deaminase n=13 Tax=Chla... 114 4e-24 UniRef50_B0SF66 Bifunctional porphobilinogen deaminase/uroporphy... 112 2e-23 UniRef50_Q6MEK3 Putative Porphobilinogen deaminase n=2 Tax=Parac... 111 4e-23 UniRef50_UPI0001B4213A porphobilinogen deaminase n=1 Tax=Listeri... 106 1e-21 UniRef50_UPI000155526F PREDICTED: similar to hydroxymethylbilane... 104 3e-21 UniRef50_UPI0001698669 porphobilinogen deaminase n=1 Tax=Endorif... 101 3e-20 UniRef50_C0EAN0 Putative uncharacterized protein n=1 Tax=Clostri... 100 1e-19 UniRef50_Q6MHU0 Hydroxymethylbilane synthase n=1 Tax=Bdellovibri... 96 1e-18 UniRef50_Q6Q923 Predicted porphobilinogen deaminase n=2 Tax=envi... 95 3e-18 UniRef50_C0DZX9 Putative uncharacterized protein n=1 Tax=Coryneb... 94 7e-18 UniRef50_D0RNS6 Putative porphobilinogen deaminase (Pbg)(Hydroxy... 89 3e-16 UniRef50_A8CBG6 Porphobilinogen deaminase n=3 Tax=Toxoplasma gon... 89 3e-16 UniRef50_C5LJF7 Porphobilinogen deaminase, putative n=5 Tax=Perk... 79 1e-13 UniRef50_Q401C3 Hydroxymethylbilane synthase (Fragment) n=7 Tax=... 79 2e-13 UniRef50_B0KCR7 Porphobilinogen deaminase n=3 Tax=Thermoanaeroba... 76 2e-12 UniRef50_UPI0001742E92 Porphobilinogen deaminase n=1 Tax=candida... 63 2e-08 UniRef50_Q1HRH6 Hydroxymethylbilane synthase-like protein n=1 Ta... 59 2e-07 UniRef50_B8N6H4 Putative uncharacterized protein n=1 Tax=Aspergi... 48 3e-04 UniRef50_UPI0000D9FBB5 PREDICTED: similar to lethal (3) 02640 CG... 43 0.016 >UniRef50_B7LU53 Porphobilinogen deaminase n=87 Tax=cellular organisms RepID=HEM3_ESCF3 Length = 313 Score = 593 bits (1528), Expect = e-168, Method: Compositional matrix adjust. Identities = 296/312 (94%), Positives = 302/312 (96%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 MLDNVLRIATRQSPLALWQAHYVKD LMA HPGL VELVPMVTRGDVILDTPLAKVGGKG Sbjct: 1 MLDNVLRIATRQSPLALWQAHYVKDALMAKHPGLTVELVPMVTRGDVILDTPLAKVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN Y SLD LP Sbjct: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNKYASLDELP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE Sbjct: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 SRIR ALPPE+SLPAVGQGAVGIECRLDD+RTRELLAALNH ETALRVTAERAMNTRLEG Sbjct: 181 SRIRDALPPEVSLPAVGQGAVGIECRLDDTRTRELLAALNHPETALRVTAERAMNTRLEG 240 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPIGSYAELI GEIWLRALVGAPDGSQ+IRGERRG+PQDAE+MGISLAEELLNNGAR Sbjct: 241 GCQVPIGSYAELIGGEIWLRALVGAPDGSQMIRGERRGSPQDAEKMGISLAEELLNNGAR 300 Query: 301 EILAEVYNGDAP 312 ILA+VYNGDAP Sbjct: 301 AILADVYNGDAP 312 >UniRef50_B5FN93 Porphobilinogen deaminase n=168 Tax=cellular organisms RepID=HEM3_SALDC Length = 313 Score = 566 bits (1459), Expect = e-160, Method: Compositional matrix adjust. Identities = 279/313 (89%), Positives = 294/313 (93%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 MLDNVLRIATRQSPLALWQAHYVKD LMA+HPGL VELVPMVTRGDVILDTPLAKVGGKG Sbjct: 1 MLDNVLRIATRQSPLALWQAHYVKDALMATHPGLTVELVPMVTRGDVILDTPLAKVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKELE+ALLE RADIAVHSMKDVPV FP GLGLVTICEREDPRDAFVSN Y SLD LP Sbjct: 61 LFVKELEIALLEKRADIAVHSMKDVPVAFPDGLGLVTICEREDPRDAFVSNKYHSLDDLP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRL KLDNG+YDAIILAVAGLKRLGLE Sbjct: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLGKLDNGDYDAIILAVAGLKRLGLE 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 SRIR ALPP++SLPAVGQGAVGIECRLDD+RT+ LLA LNH +TALRVTAERAMNTRLEG Sbjct: 181 SRIRTALPPDVSLPAVGQGAVGIECRLDDARTQALLAPLNHSQTALRVTAERAMNTRLEG 240 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPIGSYAE+I+GEIWLRALVGAPDGS ++RGERRG+P+ AEQMGISLAEELL NGAR Sbjct: 241 GCQVPIGSYAEIINGEIWLRALVGAPDGSVMVRGERRGSPEQAEQMGISLAEELLENGAR 300 Query: 301 EILAEVYNGDAPA 313 IL EVYNG+ PA Sbjct: 301 AILTEVYNGETPA 313 >UniRef50_Q0I178 Porphobilinogen deaminase n=45 Tax=Bacteria RepID=HEM3_HAES1 Length = 321 Score = 387 bits (993), Expect = e-106, Method: Compositional matrix adjust. Identities = 199/318 (62%), Positives = 236/318 (74%), Gaps = 11/318 (3%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 ++ L+IATRQSPLALWQA+YVK++L + L VELVP++T+GDVILDTPLAK+GGKGL Sbjct: 3 INKTLKIATRQSPLALWQANYVKNRLQQRYSHLSVELVPIITKGDVILDTPLAKIGGKGL 62 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKELE ALL ADIAVHSMKDVP++FP+GL L IC REDPRDAFVSN Y +LD LP Sbjct: 63 FVKELENALLNGEADIAVHSMKDVPMQFPKGLELSVICPREDPRDAFVSNKYRTLDELPQ 122 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+IVGTSSLRRQCQL R DL IRSLRGNVGTRL+KLD G+YDAIILA AGL RLGL Sbjct: 123 GAIVGTSSLRRQCQLKNWRADLDIRSLRGNVGTRLNKLDQGDYDAIILASAGLIRLGLTE 182 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 RIR+ + + LPA GQGAVGIECR+DD + LL L T V AERAMN L+GG Sbjct: 183 RIRSFIEIDTILPACGQGAVGIECRVDDRDVQSLLMPLADQTTTYCVLAERAMNFHLQGG 242 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE-----------RRGAPQDAEQMGISL 290 CQVPIG+YA L + +++LR LVG GSQI+ E + A Q AE++G+S+ Sbjct: 243 CQVPIGAYAILENNQLYLRGLVGDVHGSQILSAEGQFELSLDFESSQSAVQKAEELGVSI 302 Query: 291 AEELLNNGAREILAEVYN 308 AE+LL GA +IL VY Sbjct: 303 AEQLLQQGADKILQAVYQ 320 >UniRef50_C0QU69 Porphobilinogen deaminase n=4 Tax=Bacteria RepID=C0QU69_PERMH Length = 308 Score = 365 bits (937), Expect = 1e-99, Method: Compositional matrix adjust. Identities = 171/304 (56%), Positives = 229/304 (75%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR+S LALWQA+Y+ D+L P L VELV +VT+GD ILD PLAKVGGKGLFVKE Sbjct: 3 IRIGTRKSKLALWQANYIADQLKKHFPDLEVELVKIVTKGDKILDVPLAKVGGKGLFVKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E A+L N DIAVHS+KDVP FP+GLGLV I EREDPRDAF+S Y+S++ +P G+++ Sbjct: 63 IEEAMLRNEIDIAVHSLKDVPTYFPEGLGLVAITEREDPRDAFLSVKYNSIEDMPEGAVL 122 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR+ Q+ +R D+ I LRGNV TR+ KL+ G+YD IILA AGLKRLGLE ++R Sbjct: 123 GTSSLRRKAQIMMKRKDIRIEDLRGNVDTRIRKLEEGQYDGIILAYAGLKRLGLEGKVRQ 182 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L P+ +PAV QG +GIE RLDD +TRE+++ LNH E+ +R AERA LEGGCQVP Sbjct: 183 ILQPDYMIPAVAQGFLGIEARLDDEKTREIVSVLNHRESEIRAKAERAFLKTLEGGCQVP 242 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 + Y+E+++G++ + V G ++ R G+ +DAE +G+ LAE+LL++GA+E+L E Sbjct: 243 LAGYSEIVNGKLKITGFVSDLTGDRVFRDSMEGSLEDAESLGVKLAEKLLSDGAKEVLEE 302 Query: 306 VYNG 309 +Y+G Sbjct: 303 IYSG 306 >UniRef50_B5YJZ4 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=B5YJZ4_THEYD Length = 311 Score = 322 bits (825), Expect = 1e-86, Method: Compositional matrix adjust. Identities = 157/306 (51%), Positives = 218/306 (71%), Gaps = 1/306 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 N + I +R S LA+WQA++VKDKL +P L VE+ + T GD ILD PLAK+GGKGLFV Sbjct: 6 NKIVIGSRGSKLAMWQANWVKDKLQTLYPELKVEIEKIKTTGDKILDAPLAKIGGKGLFV 65 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE+E ALL R D+AVHSMKDVP E P+GL + ICEREDPRDAF+S + L+ LP + Sbjct: 66 KEIEEALLSKRVDLAVHSMKDVPTEIPEGLQISAICEREDPRDAFISKDGVLLNELPQEA 125 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 ++GTSSLRR QL R DL+I+ LRGNV TR+ KL +GE+ AI+LA+AG+KR+G+E+ + Sbjct: 126 VLGTSSLRRTVQLKALRNDLVIKPLRGNVDTRIRKLKDGEFQAIVLAMAGVKRMGVENLV 185 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 A ++ +PA+GQGA+GIE R+DD EL+ LNH ETA+ + AERA + + GGCQ Sbjct: 186 TQAFSEDLMIPAIGQGAIGIETRVDDDFVNELIKPLNHEETAICILAERAFLSVMGGGCQ 245 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQ-IIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 VP+ +A +++ + + ++G P+G +I+G R G+ A+ +G+ LA ELL+ G +EI Sbjct: 246 VPLACHARIVNNSLKIVGMIGDPEGKMPVIKGFREGSLSQAQSLGVELANELLHRGGKEI 305 Query: 303 LAEVYN 308 L +VY Sbjct: 306 LEKVYK 311 >UniRef50_A1AUE7 Porphobilinogen deaminase n=44 Tax=Bacteria RepID=HEM3_PELPD Length = 310 Score = 307 bits (787), Expect = 2e-82, Method: Compositional matrix adjust. Identities = 166/303 (54%), Positives = 202/303 (66%), Gaps = 1/303 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LRI TR S LALWQA++VK +L +P + V L + T GD ILD PLA+VGGKGLFVKE Sbjct: 6 LRIGTRASQLALWQANWVKSELEKRYPAMEVTLTKIKTMGDRILDVPLAQVGGKGLFVKE 65 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E A+L DIAVHSMKDVP EFP+GLGL I EREDPRDA VS LP G+ V Sbjct: 66 IEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVVSRAA-RFSHLPPGARV 124 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTS+LRRQ QL RPDL + ++RGNV TR+ KLD DA+ILA AGLKRLGL R+ Sbjct: 125 GTSALRRQAQLLHARPDLEMVTIRGNVETRIRKLDEENLDAVILAAAGLKRLGLTQRVAE 184 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L E S+PA+GQGA+GIECRL D E +A NH +T+ V AERA+ R +GGCQVP Sbjct: 185 YLDVEFSIPAIGQGALGIECRLSDPVVTEAIAFFNHPDTSHAVRAERALLRRCQGGCQVP 244 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 I ++ + GE+ L L+ A DG + +R E G E +G LA+ LL+ G R IL E Sbjct: 245 IAAHGTIRGGELRLVGLIAAVDGREFVRDEISGPVDQCEHLGEELADRLLSRGGRAILEE 304 Query: 306 VYN 308 VY Sbjct: 305 VYQ 307 >UniRef50_B5EBG8 Porphobilinogen deaminase n=166 Tax=Bacteria RepID=HEM3_GEOBB Length = 318 Score = 306 bits (784), Expect = 6e-82, Method: Compositional matrix adjust. Identities = 158/303 (52%), Positives = 204/303 (67%), Gaps = 1/303 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LRI TR S LALWQA++VK +L +P + V L + T GD ILD PLA+VGGKGLFVKE Sbjct: 6 LRIGTRASQLALWQANWVKSELEKRYPDMTVTLTKIKTIGDKILDVPLAQVGGKGLFVKE 65 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E A+L DIAVHSMKDVP EFP+GLGL I EREDPRDA +SN D LP G+ + Sbjct: 66 IEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVISNGVKFAD-LPQGARI 124 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTS+LRRQ QL + RPDL + +RGNV TR+ KL DA+ILA AGL RLG +I Sbjct: 125 GTSALRRQAQLLKVRPDLEMVIIRGNVQTRMDKLKTEGLDAVILAAAGLNRLGFADQITE 184 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 LP ++SLPA+GQGA+GIEC L + ++ ++ N +T+ V AERA+ R EGGCQVP Sbjct: 185 MLPTDLSLPAIGQGALGIECNLSNQDVKDAISFFNSPDTSRAVRAERALLWRCEGGCQVP 244 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 I ++ E+ ++ L + + DG ++G G D E++G+ LAE+LL+ G ILAE Sbjct: 245 IAAFGEVTGDQLKLTGFIASVDGKVSVKGVVTGPADDCEKLGVKLAEQLLSEGGHAILAE 304 Query: 306 VYN 308 VY Sbjct: 305 VYQ 307 >UniRef50_Q30Y29 Porphobilinogen deaminase n=13 Tax=Bacteria RepID=HEM3_DESDG Length = 316 Score = 305 bits (780), Expect = 2e-81, Method: Compositional matrix adjust. Identities = 167/307 (54%), Positives = 209/307 (68%), Gaps = 3/307 (0%) Query: 8 IATRQSPLALWQAHYVKDKLMASHP-GLVVELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66 IATR S LALWQA ++K+++M +P VEL+ + T+GD+ILD PLAKVGGKGLFVKE+ Sbjct: 6 IATRGSKLALWQAEHIKERIMQQYPDSFEVELLVLKTKGDIILDVPLAKVGGKGLFVKEI 65 Query: 67 EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126 E ALL+ RADIAVHSMKDVP+E PQGL L I ERE P D+ +S YD LDALP G++VG Sbjct: 66 EEALLDGRADIAVHSMKDVPMELPQGLTLGAIPEREVPTDSLLSARYDGLDALPQGAVVG 125 Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAA 186 TSSLRRQ Q+ RPDL ++ LRGNV TR+ KL +GEYDAII+A +GLKRLG + + Sbjct: 126 TSSLRRQSQILAMRPDLEVKWLRGNVQTRIRKLMDGEYDAIIMATSGLKRLGETAPFHSE 185 Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246 L P + +PAVGQGA+G+E R D E+LA L+H + + V AER L+GGCQVPI Sbjct: 186 LGPPLFMPAVGQGALGLEYRSDRQDLAEMLAFLDHRPSRICVEAERGFLFGLQGGCQVPI 245 Query: 247 GSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 YA + D L LV DG+ +IR G DA G++LA ++ GA IL Sbjct: 246 AGYAVMTGDNSFELTGLVAELDGTAVIRRTAAGTEADARDTGLTLAAQVKAAGADAILQR 305 Query: 306 VY-NGDA 311 VY NG A Sbjct: 306 VYENGHA 312 >UniRef50_A7GYU4 Porphobilinogen deaminase n=34 Tax=Campylobacterales RepID=HEM3_CAMC5 Length = 311 Score = 301 bits (771), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 160/302 (52%), Positives = 201/302 (66%), Gaps = 3/302 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +L+IATR+S LALWQ+ ++K +LMA H GL VELV M T+GDVILDTPLAK+GGKGLF Sbjct: 2 KILKIATRKSALALWQSEHIKARLMAQHAGLQVELVGMKTKGDVILDTPLAKIGGKGLFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE ++L + IAVHS+KDVPV F GL L IC RED RDA +S Y D LP + Sbjct: 62 KELEDSMLSGQTHIAVHSLKDVPVAFLDGLVLAAICSREDVRDAMISQRYVKFDDLPQSA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGT+SLRR+ QL RPDL I SLRGNV TRL KL GE+DAIILA+AG+ RL L + Sbjct: 122 KVGTTSLRRKMQLLRMRPDLNIISLRGNVQTRLRKLKEGEFDAIILAMAGINRLNLADEV 181 Query: 184 RAALPPEIS--LPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 P +I+ PA+GQGA+G+E +DD++ E + LN + + ER T LEGG Sbjct: 182 AHIYPFDIAQMTPAMGQGALGVEA-VDDAQILEKIKFLNDERSVIETRVERDFVTLLEGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 CQVPIG A L EI + A+VG PDGS++I + E +G LA E + GA+E Sbjct: 241 CQVPIGINARLASEEIEINAIVGLPDGSEVITENLTAKKSEFESVGKELAREFIARGAKE 300 Query: 302 IL 303 +L Sbjct: 301 LL 302 >UniRef50_Q5ZRY6 Porphobilinogen deaminase n=6 Tax=Legionella RepID=HEM3_LEGPH Length = 309 Score = 296 bits (757), Expect = 7e-79, Method: Compositional matrix adjust. Identities = 153/307 (49%), Positives = 204/307 (66%), Gaps = 1/307 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M ++RIATRQSPLALWQA++V++ L+ P L +EL+PM+T GD L L GGKG Sbjct: 1 MSAKIIRIATRQSPLALWQANHVREMLVKQWPNLSIELLPMITSGDRFLKDKLLSAGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKELE ALL+ RAD+AVHS KD+P + P GL L IC+R++P DA +S + SL ALP Sbjct: 61 LFVKELEEALLDKRADLAVHSTKDMPAQLPDGLLLTAICKRDNPFDALISPQFKSLAALP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 +I+GTSSLRRQ QL P+L I++LRGN+ TRLSKL++GEY AIILA AGL+R+GL Sbjct: 121 KNAIIGTSSLRRQSQLLAYNPNLQIKTLRGNIHTRLSKLESGEYQAIILAAAGLERMGLA 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 I +P +I LP QGA+ IECR DD +EL+ LN +AL V ER +N +L G Sbjct: 181 HHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELVHGLNDPISALCVHTERRVNAKLGG 240 Query: 241 GCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 C +P Y + + + + LRA V DGSQ+I E++G +AE + E L+ GA Sbjct: 241 NCHIPFAVYCTITEEKLLLLRAKVLNMDGSQMIDDEQQGKIAEAEVIADRCTESLMTKGA 300 Query: 300 REILAEV 306 +L+ + Sbjct: 301 MSLLSTI 307 >UniRef50_B3E2H7 Porphobilinogen deaminase n=3 Tax=Proteobacteria RepID=HEM3_GEOLS Length = 312 Score = 293 bits (751), Expect = 4e-78, Method: Compositional matrix adjust. Identities = 160/303 (52%), Positives = 205/303 (67%), Gaps = 1/303 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LRI TR S LALWQA++ K +L A +PG+ VELV + T GD ILD PLA+VGGKGLFVKE Sbjct: 6 LRIGTRASQLALWQANWTKSELEARYPGIQVELVKIKTMGDKILDVPLAQVGGKGLFVKE 65 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E A+L D+AVHSMKDVP EFP+GLGLV +REDPRDAF+S+ + L G+ + Sbjct: 66 IEEAMLRGEIDLAVHSMKDVPTEFPEGLGLVVTTKREDPRDAFISDKV-TFSELRQGARI 124 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTS+LRRQ QL + RPDL + +RGNV TR+ KL DA+ILA AGL RLG + Sbjct: 125 GTSALRRQAQLLKARPDLEMVIIRGNVETRIRKLKEDNLDAVILAAAGLNRLGFTDVVTE 184 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L + S+PA+GQGA+G+ECRLDD+ T E LA LNH +TA V AERA+ R EGGCQVP Sbjct: 185 LLDTDFSIPAIGQGALGLECRLDDNATIEALAFLNHADTAAAVAAERALLKRCEGGCQVP 244 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 I ++ + + L + + DG Q +R G+ DA ++G LA+ LL G + IL + Sbjct: 245 IAAHGTVSGDTLTLVGFIASVDGKQTVRDRISGSTADAVKLGTELADRLLAAGGKAILED 304 Query: 306 VYN 308 VY Sbjct: 305 VYQ 307 >UniRef50_C9KL85 Hydroxymethylbilane synthase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KL85_9FIRM Length = 315 Score = 293 bits (749), Expect = 6e-78, Method: Compositional matrix adjust. Identities = 162/307 (52%), Positives = 201/307 (65%), Gaps = 1/307 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M ++ + I TR S LALWQA YV D L +P L VE M T+GD ILD PLAK+GGKG Sbjct: 1 MKNDTIVIGTRSSKLALWQADYVADCLRKRYPELRVEKKLMTTKGDKILDAPLAKIGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF KELE +L DIAVHS+KD+P E P+GL + I ER DP DA VS Y +L+ LP Sbjct: 61 LFTKELEQDMLAGGIDIAVHSLKDMPTEVPEGLVISAITERFDPGDAVVSPKYRTLENLP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGTSSLRR+ QL RPDL I LRGNV TRL KL+ +DAIILAVAGLKRLG Sbjct: 121 QGAKVGTSSLRRKAQLLHARPDLQISDLRGNVNTRLEKLEREHFDAIILAVAGLKRLGFA 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 RI LP E+ LPAVGQGA+ IE R +D R L+A LN T AERA R+EG Sbjct: 181 DRITEVLPREMVLPAVGQGALAIETRENDREVRNLIAFLNDEATVACARAERAFLARVEG 240 Query: 241 GCQVPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GCQVP+G YA +G + + A++ + DG+++ R G+ +AE +G +LA++LL G Sbjct: 241 GCQVPVGVYAVPEAEGRLHVEAVIASLDGARLYRDAAVGSAAEAESLGTALADKLLAMGG 300 Query: 300 REILAEV 306 IL E+ Sbjct: 301 IAILHEI 307 >UniRef50_C6HUG2 Porphobilinogen deaminase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HUG2_9BACT Length = 321 Score = 292 bits (747), Expect = 1e-77, Method: Compositional matrix adjust. Identities = 158/304 (51%), Positives = 206/304 (67%), Gaps = 2/304 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LALWQA +V ++ GL EL + T GD+IL PL++VGGKGLFVKE Sbjct: 10 IRIGTRGSELALWQARHVA-AMIRHTAGLESELTIIKTTGDMILSVPLSQVGGKGLFVKE 68 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E AL+ D+AVHSMKDVP P+GL + I REDPRDAFVSN Y S +LP G+ + Sbjct: 69 IEEALIAGTIDLAVHSMKDVPAFLPEGLEIGAILSREDPRDAFVSNAYSSFSSLPPGARI 128 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR QL +RRPDL SLRGNVGTRL KLD + DAIILA AGL RLG RIR Sbjct: 129 GTSSLRRMAQLKKRRPDLRFESLRGNVGTRLRKLDENQIDAIILAAAGLIRLGFSDRIRE 188 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 LP E+SLPAVGQGA+G+ECR D R R +LA ++ ET V AER + + L+GGCQ+P Sbjct: 189 YLPVELSLPAVGQGALGLECRTGDHRIRTILARMHDPETTACVLAERGVLSALDGGCQLP 248 Query: 246 IGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 I ++A I E I L A + +G+ ++ G ++A ++G+ A++LL+ G ++IL Sbjct: 249 IAAHARTISPEQIELIARILDVEGTTLLEEHTSGPAKEAHRLGVEAAQKLLSRGGQKILT 308 Query: 305 EVYN 308 ++ + Sbjct: 309 DILS 312 >UniRef50_Q8YVU6 Porphobilinogen deaminase n=50 Tax=cellular organisms RepID=HEM3_ANASP Length = 323 Score = 291 bits (744), Expect = 3e-77, Method: Compositional matrix adjust. Identities = 152/306 (49%), Positives = 201/306 (65%), Gaps = 3/306 (0%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +RI +R+S LAL Q ++V+++L S P + E+ M T+GD ILD LAK+G KGLF K Sbjct: 11 TIRIGSRKSQLALVQTYWVREQLQNSFPDINFEVHTMSTQGDKILDVALAKIGDKGLFTK 70 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN-NYD--SLDALPA 121 ELEV ++ D AVHS+KD+P P+GL L I ERE+P DA V + N+ +D LPA Sbjct: 71 ELEVGMINEEIDFAVHSLKDLPTNLPEGLALAAITERENPADALVVHENFKDKQIDTLPA 130 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+++GTSSLRR QL + P L + +RGN+ TRL+KLD GEYD +ILA AGL+RLG+ Sbjct: 131 GAVIGTSSLRRLAQLRNQFPHLTFKDVRGNLNTRLAKLDAGEYDGLILAAAGLQRLGMGD 190 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 R+ LP EISL AVGQGA+GIECR DD+ +L A+ H ET R AER+ LEGG Sbjct: 191 RVHQILPKEISLHAVGQGALGIECRADDAELITVLKAIEHPETRDRCLAERSFLRSLEGG 250 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 CQVPIG E+ E+ L +V + DG +++ G DAE +GI LAE L GA+E Sbjct: 251 CQVPIGVNTEINGNELILTGVVASVDGQNLVKDTVSGNASDAEAIGIRLAELLREQGAQE 310 Query: 302 ILAEVY 307 IL ++ Sbjct: 311 ILNTIF 316 >UniRef50_Q3ACT3 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=HEM3_CARHZ Length = 311 Score = 288 bits (736), Expect = 2e-76, Method: Compositional matrix adjust. Identities = 146/299 (48%), Positives = 200/299 (66%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67 + +R S LALWQ ++V ++L HP + ++V M T+GD ILD LAK+G KGLF KELE Sbjct: 7 VGSRDSALALWQTNWVVERLSKIHPEINFKIVTMKTKGDKILDVALAKIGDKGLFTKELE 66 Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127 ALL D+AVHSMKD+P P+GL + CERE P D F+S LP G+ +GT Sbjct: 67 HALLNKTIDMAVHSMKDLPTVLPEGLKIGAFCEREYPGDVFISPKGFKFLELPQGARIGT 126 Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAAL 187 SSLRR Q+ RPDL LRGN+ TR K++ + D IILA AG+KRLG E +I L Sbjct: 127 SSLRRIAQILAVRPDLQAIPLRGNLPTRFRKMEEMDLDGIILAYAGVKRLGYEDKITEML 186 Query: 188 PPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIG 247 ++ LPAVGQG++G+E R DD+ ELL ++H T + AERA RLEGGCQ+PIG Sbjct: 187 SFDLCLPAVGQGSIGVEIRADDTFIEELLKPIDHFATNRAIRAERAFLKRLEGGCQIPIG 246 Query: 248 SYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEV 306 +Y+E+ + + L+ +V + DG +I+GE+ G+ ++ E++GISLAEELL GA++IL E+ Sbjct: 247 AYSEVKENRLHLKGVVASLDGKLVIKGEKEGSIEEPEKVGISLAEELLTKGAQKILEEI 305 >UniRef50_D0LUE1 Porphobilinogen deaminase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LUE1_HALO1 Length = 320 Score = 286 bits (732), Expect = 6e-76, Method: Compositional matrix adjust. Identities = 161/314 (51%), Positives = 204/314 (64%), Gaps = 11/314 (3%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M + + I+TR S LALWQAH+V+D++ P VELV + T+GD ILD PL+K+GGK Sbjct: 1 MSERTIHISTRGSQLALWQAHHVRDEIRRVRPAWQVELVIIKTQGDKILDVPLSKIGGKA 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E ALL+ RAD+AVHSMKDVP E GL + REDP DA + + LD L Sbjct: 61 LFVKEIEQALLDGRADVAVHSMKDVPAELAPGLFMAATSRREDPYDALCTRDGRGLDELA 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GTSSLRRQCQ+ RRPDL I LRGNV TRL KLD+G +DA+ILA AGLKRLG Sbjct: 121 EGATLGTSSLRRQCQILARRPDLRIEMLRGNVPTRLGKLDDGSFDAVILAAAGLKRLGHG 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDS-RTRELLAALNH--HETA--LRVTAERAMN 235 RI L + +PAVGQG +GIE R D+ REL+ AL H+ A RV AERAM Sbjct: 181 ERISQRLDGGVCVPAVGQGVLGIETRQGDAPADRELVEALREALHDPAEERRVVAERAMM 240 Query: 236 TRLEGGCQVPIGSYAEL------IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGIS 289 L G CQ P+ ++A + G + + L G PDGS+I+R + G +DA+ +G S Sbjct: 241 AALGGSCQTPLAAHASYRGDSDPVAGTLVIEGLCGRPDGSEILRAQVEGRAEDAQALGSS 300 Query: 290 LAEELLNNGAREIL 303 LAEEL GA+ I+ Sbjct: 301 LAEELRGQGAQAII 314 >UniRef50_Q8DIE4 Porphobilinogen deaminase n=11 Tax=cellular organisms RepID=HEM3_THEEB Length = 320 Score = 285 bits (729), Expect = 1e-75, Method: Compositional matrix adjust. Identities = 150/305 (49%), Positives = 198/305 (64%), Gaps = 3/305 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI +R+S LAL Q +V+ +L H E+V M T+GD ILD LAK+G KGLF KE Sbjct: 9 VRIGSRKSQLALVQTEWVQAQLQTHHRDRAFEVVTMTTQGDNILDVALAKIGDKGLFTKE 68 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDSLDALPAG 122 LE+++L D+AVHS+KD+P + P GL L I EREDP DA V ++D LP G Sbjct: 69 LELSMLRGETDLAVHSLKDLPTQLPDGLVLAAITEREDPADALVLGAKWTGHTIDTLPEG 128 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 +++GTSSLRR QL P L + +RGN+ TRL+KLD GEYDA+ILAVAGL+RLG R Sbjct: 129 TVIGTSSLRRLAQLRHYYPHLTFKDVRGNLNTRLAKLDAGEYDALILAVAGLRRLGFGDR 188 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 I LP +SL AVGQGA+GIECR +D+ L+ L H ET R AERA +LEGGC Sbjct: 189 ISQVLPATVSLYAVGQGALGIECRAEDADILALVKTLEHPETTARCLAERAFLRQLEGGC 248 Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 QVPIG + + +G++ L LV + DG ++++ G AE++G LA +L GA EI Sbjct: 249 QVPIGVHTVIENGQLTLTGLVASLDGQRLVKDSLTGDVATAEELGTRLALKLREQGASEI 308 Query: 303 LAEVY 307 L E++ Sbjct: 309 LEEIF 313 >UniRef50_D1BNZ5 Porphobilinogen deaminase n=3 Tax=Veillonella RepID=D1BNZ5_VEIPT Length = 312 Score = 276 bits (706), Expect = 7e-73, Method: Compositional matrix adjust. Identities = 144/298 (48%), Positives = 192/298 (64%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR+S LALWQA ++ +L +P + VELV T+GD IL+ PLA+VGGKGLF E Sbjct: 5 IRIGTRKSALALWQAEHISAELQRLYPNITVELVHFNTKGDRILEKPLAQVGGKGLFTAE 64 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE A+ DIAVHS+KD+P E P+GL L I RE P DA VS Y +LD LP G+ V Sbjct: 65 LEEAMHAGDIDIAVHSLKDMPTELPEGLTLGAISAREVPYDALVSPVYKTLDKLPQGARV 124 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRRQ QL RPDL + +RGNV TRLSK++ + D +ILA AGLKRLGLE +I Sbjct: 125 GTSSLRRQAQLLHVRPDLKVEVIRGNVQTRLSKIETEKLDGVILAQAGLKRLGLEDQITQ 184 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 + +PAVGQGA+ IECR DD+ ++L +N T V ER+ +L GGCQVP Sbjct: 185 VFKADEMIPAVGQGALAIECRADDTEMLDMLDPINDEATRYAVEGERSFLRQLNGGCQVP 244 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 +G + + G++ L+A++ + DG + GE G + E +G +LA+ L G + I+ Sbjct: 245 MGVHGTINKGQLTLKAMIASLDGKTVYEGEISGPAKKGEILGKNLAKALYEEGGKRIV 302 >UniRef50_A9FDP9 Porphobilinogen deaminase n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=HEM3_SORC5 Length = 300 Score = 276 bits (705), Expect = 8e-73, Method: Compositional matrix adjust. Identities = 152/293 (51%), Positives = 195/293 (66%), Gaps = 4/293 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L +ATR+S LAL Q+ L A+ P L + + +VT GD D L +GGKGLF+KE Sbjct: 5 LTLATRRSALALAQSRAFARSLEAAVPDLSLRELEVVTSGDKTQDRSLQDIGGKGLFIKE 64 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE ALL+ RAD AVHS+KDVP E L L I REDPRDA V+ + L LPAG+ V Sbjct: 65 LEEALLDRRADFAVHSIKDVPAEIAPALCLACIPAREDPRDALVTRSGALLAELPAGARV 124 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR L E RPDL+I +RGNV TRL K+ +G +DA++LA+AGLKRLGLE+R Sbjct: 125 GTSSLRRAVALREARPDLVIEPVRGNVDTRLRKVFDGVFDAVVLALAGLKRLGLEARATE 184 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L PE+SLPA+GQGA+GIECR D R++L L ET + V+AERA+ +EG C+ P Sbjct: 185 VLSPEVSLPAIGQGALGIECRTADDSVRDVLGTLADAETTICVSAERAVMAAVEGSCRTP 244 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERR----GAPQDAEQMGISLAEEL 294 + +YA G +WLRAL+ PDGS++ R ERR G ++AE++G L EL Sbjct: 245 VAAYAVRDGGALWLRALLAEPDGSRLRRAERRLSWPGNTREAERLGADLGAEL 297 >UniRef50_A7NKU8 Porphobilinogen deaminase n=5 Tax=Bacteria RepID=HEM3_ROSCS Length = 303 Score = 275 bits (704), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 152/301 (50%), Positives = 194/301 (64%), Gaps = 1/301 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 N L I TR S LAL Q H ++D L A+HPGL V + + TRGD+ILD PL +G KGLFV Sbjct: 3 NSLTIGTRASKLALVQTHMIRDALQAAHPGLTVAVERITTRGDIILDRPLNAIGDKGLFV 62 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 E+E A+ R D+AVHS KD+P P + L R DPRDA V+ +L +LP G+ Sbjct: 63 VEIEEAMRAGRVDLAVHSAKDLPSTLPPDMTLAVCPRRADPRDALVAQPGMTLASLPHGA 122 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGTSSLRR CQL RPDL + LRGNV TRL KL G+YDAI+LA AGLKRLGLE I Sbjct: 123 RVGTSSLRRACQLRALRPDLTLLDLRGNVDTRLRKLREGQYDAIVLAAAGLKRLGLEEVI 182 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 L P++ +PAVGQG +G+E R D LLA L+ +TAERA R+ GGC+ Sbjct: 183 TELLEPDVLIPAVGQGIIGVEARAGDDEVLRLLAPLDDPAARAAITAERAFLARIGGGCR 242 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 VP+G+ A L E+ L ++GA DG +++RG R G+ D +G +LAEELL+ G + +L Sbjct: 243 VPVGALALLEGDELLLYGMIGALDG-RMVRGMRSGSASDPAGLGSALAEELLDAGGQALL 301 Query: 304 A 304 A Sbjct: 302 A 302 >UniRef50_Q31PM2 Porphobilinogen deaminase n=8 Tax=cellular organisms RepID=HEM3_SYNE7 Length = 320 Score = 275 bits (704), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 150/305 (49%), Positives = 200/305 (65%), Gaps = 3/305 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI +R+S LAL Q H+V+ +L +P ++ M T+GD+ILD LAK+G KGLF KE Sbjct: 9 IRIGSRKSQLALVQTHWVQGELQRLYPDRQFDVQTMSTQGDIILDVALAKIGDKGLFTKE 68 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLDALPAG 122 LEVA+L D AVHS+KD+P P+GL L + EREDP DA V ++ L+ LP G Sbjct: 69 LEVAMLAGEVDFAVHSLKDLPTRLPEGLILGCVTEREDPADALVVHDRFKDHQLETLPEG 128 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 +++GTSSLRR QL P L + +RGN+ TRL+KLD GEYDA+ILA AGL+RL + R Sbjct: 129 TVIGTSSLRRLAQLRHHYPHLQFKDVRGNLNTRLAKLDAGEYDALILAAAGLQRLSMADR 188 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 I +P +SL AVGQGA+GIECR +D ELL AL H T+ R AERA LEGGC Sbjct: 189 IHQLIPAAVSLHAVGQGALGIECRAEDPEILELLKALEHEPTSQRCLAERAFLRELEGGC 248 Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 QVPIG + DG + L +V + DG +++R + G D E +G++LA +L GA+EI Sbjct: 249 QVPIGVNTAIADGTLTLTGMVASLDGQRLLRDQVSGPTSDPEALGLALAAQLKAQGAKEI 308 Query: 303 LAEVY 307 L E++ Sbjct: 309 LDEIF 313 >UniRef50_Q4HT06 Porphobilinogen deaminase n=1 Tax=Campylobacter upsaliensis RM3195 RepID=Q4HT06_CAMUP Length = 308 Score = 275 bits (703), Expect = 2e-72, Method: Compositional matrix adjust. Identities = 151/300 (50%), Positives = 201/300 (67%), Gaps = 4/300 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L IATR+SPLALWQ+ +V D L +H G+ V L T+GD++LD+PLAK+GGKGLF KE Sbjct: 4 LIIATRKSPLALWQSEFVADILRKTH-GIEVHLEGFSTKGDILLDSPLAKIGGKGLFTKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE A+LEN+A +AVHS+KDVP PQGL L + RED DA +S Y L+ALP + V Sbjct: 63 LENAMLENKAHLAVHSLKDVPSFLPQGLVLAALSVREDDTDALLSELYKDLNALPQNAKV 122 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT+SLRR+ QL RPDL I +LRGNV +RL +L GE+DAIILA AG+KRLGLES ++ Sbjct: 123 GTTSLRRKMQLLSLRPDLHIINLRGNVNSRLKRLKGGEFDAIILASAGVKRLGLESEVKF 182 Query: 186 A--LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + +PA QG +GI+ D + LL LN ++ + T ER LEGGCQ Sbjct: 183 IYRFSKDELVPAATQGILGIQSP-DKNEILTLLQCLNDEKSLIESTVERDFIRTLEGGCQ 241 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 VPIG AEL+ +I +R+++G PDGS+I+R +R ++ + G LA E + GA+E+L Sbjct: 242 VPIGINAELMGEQITVRSILGLPDGSEILRDKRIILKKNYQGFGERLALEFIKRGAKELL 301 >UniRef50_C0Q9U2 HemC n=2 Tax=Bacteria RepID=C0Q9U2_DESAH Length = 325 Score = 275 bits (703), Expect = 2e-72, Method: Compositional matrix adjust. Identities = 146/302 (48%), Positives = 197/302 (65%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + ++I TR S LALWQA++VKD++ P VE++ + T GD+I+D PL+ VGGKGL Sbjct: 19 MKKTIKIGTRGSKLALWQANHVKDRIEDQFPETEVEIMTIKTTGDMIVDRPLSMVGGKGL 78 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKE+E ALLE+ D+AVHSMKD+P E P GL + + RE+P D +SNN SL LP Sbjct: 79 FVKEIEKALLESTIDMAVHSMKDMPGELPPGLVIGAVPARENPFDVLISNNNLSLADLPK 138 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ +GTSSLRR Q+ RPD+ S+RGN+ TRL KL GE+DA +LA AGL RLG+++ Sbjct: 139 GARIGTSSLRRASQIKHARPDIETASIRGNLDTRLKKLAAGEFDATLLAAAGLIRLGMKT 198 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 I I +PAVGQGA+ IE R +D +LA LNH ET V+ ERA RL+G Sbjct: 199 VITQYFDETIMIPAVGQGALCIESRQEDLDIAPVLAFLNHGETHTVVSGERAFLRRLDGS 258 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 C +P+ + L D + L LV + DG I++ G P+D ++ GI+LAE LL+ GA + Sbjct: 259 CHIPVACFGRLEDHRVILTGLVASEDGRTILKETVAGTPEDPQKAGIALAETLLSKGADK 318 Query: 302 IL 303 IL Sbjct: 319 IL 320 >UniRef50_B3QWI1 Porphobilinogen deaminase n=12 Tax=Chlorobiaceae RepID=HEM3_CHLT3 Length = 314 Score = 273 bits (697), Expect = 7e-72, Method: Compositional matrix adjust. Identities = 145/314 (46%), Positives = 196/314 (62%), Gaps = 4/314 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + L I TR SPLALWQA ++K +L +P L + L + T GD ILD PLAK+G KGL Sbjct: 1 MKKALIIGTRSSPLALWQAEFIKAELSKHYPSLDISLRHIKTTGDKILDAPLAKIGDKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F +E+E +L N D+AVHS+KD+P E P+GL + I ERED RD +S +L LP Sbjct: 61 FTREIEHVMLRNEIDLAVHSLKDLPTETPEGLVITAITEREDNRDVLISKGKYTLKTLPQ 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+IV TSSLRR+ QL RPDL + +RGN+ TR + + G+ +A++LA AG+ RL Sbjct: 121 GAIVATSSLRRRSQLLHLRPDLEVIDMRGNLNTRFKRFEEGDAEAMLLAFAGVHRLEFSE 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 I + + LPAVGQGA+GIE R+DD TRELL LNH ET L ER++ LEGG Sbjct: 181 HIAEIISFDDILPAVGQGALGIETRIDDEETRELLKVLNHAETELCTKCERSLLRTLEGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRG----ERRGAPQDAEQMGISLAEELLNN 297 CQ+PIG++A + +G VG+ DG + I+ E ++AEQ+GI +A+ Sbjct: 241 CQIPIGAHARIENGTFHFATYVGSIDGKRAIKKSLSRENVTTVEEAEQIGIEVADAARAA 300 Query: 298 GAREILAEVYNGDA 311 GA EIL E+ +A Sbjct: 301 GANEILCEIRTDNA 314 >UniRef50_A3MLK5 Porphobilinogen deaminase n=155 Tax=Proteobacteria RepID=HEM3_BURM7 Length = 329 Score = 270 bits (691), Expect = 4e-71, Method: Compositional matrix adjust. Identities = 151/270 (55%), Positives = 191/270 (70%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 L L IA+R+S LA+WQA +V+D L +P V+++ M TRGD ILD L+KVGGKGL Sbjct: 10 LPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGL 69 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKELE AL + RAD+AVHS+KDVP+ P+G L + REDPRDAFVSN+Y SLDALPA Sbjct: 70 FVKELESALADGRADLAVHSLKDVPMALPEGFALAAVMSREDPRDAFVSNDYASLDALPA 129 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G++VGTSSLRR+ L R P L +R LRGN+ TRL+KLD G+Y AIILA AGLKRLGL + Sbjct: 130 GAVVGTSSLRREAMLRARHPRLDVRPLRGNLDTRLAKLDRGDYAAIILAAAGLKRLGLAA 189 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 RIRA L + SLPA GQGA+GIE + LA L+ H +AL V AERA++ L G Sbjct: 190 RIRALLDVDDSLPAAGQGALGIEIAARRADVAAWLAPLHDHASALAVEAERAVSRALGGS 249 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQI 271 C+VP+ ++A GE+ L V DG+++ Sbjct: 250 CEVPLAAHAVWRGGELHLTGSVSTTDGARV 279 >UniRef50_Q8D2W2 HemC protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis RepID=Q8D2W2_WIGBR Length = 291 Score = 268 bits (684), Expect = 3e-70, Method: Compositional matrix adjust. Identities = 132/284 (46%), Positives = 192/284 (67%), Gaps = 1/284 (0%) Query: 24 KDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMK 83 K KL+ HP L ++LVP++T GD+I KGLF+KELE +LL+ ++DIAVHSMK Sbjct: 7 KKKLLHYHPKLNIKLVPILTTGDLINKIRNNITNEKGLFIKELEKSLLKYQSDIAVHSMK 66 Query: 84 DVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDL 143 D F LGL IC+R+DPRDA VSN Y+++ +LP + VGTSSLRR+CQL RPDL Sbjct: 67 DFSSSFLDSLGLAAICKRDDPRDAIVSNYYNNIISLPNNAKVGTSSLRRKCQLLSIRPDL 126 Query: 144 IIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGI 203 I +GN+ +RL KL+ G +DA+ILA A LKRL + ++ + P LPA+GQG++ I Sbjct: 127 KIFPCKGNIHSRLKKLNQGVFDALILATAALKRLKINEQMYTPIDPSYLLPAMGQGSIAI 186 Query: 204 ECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID-GEIWLRAL 262 +CRL D++ +++ +N+ +TAL + +E+ + + L GC+VPIGSYA++ + IW+RAL Sbjct: 187 QCRLYDNKIIDIVRNINNKKTALCINSEKIVVSMLGTGCRVPIGSYAKIENKNTIWIRAL 246 Query: 263 VGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEV 306 VG+ DGS IIR E + +AE++ + L+N GA+ IL + Sbjct: 247 VGSIDGSNIIRSEGKSCVSNAEKLSKKQVKNLINLGAKNILKKF 290 >UniRef50_A6TJD5 Porphobilinogen deaminase n=2 Tax=Firmicutes RepID=HEM3_ALKMQ Length = 316 Score = 264 bits (675), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 141/306 (46%), Positives = 192/306 (62%), Gaps = 1/306 (0%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 ++I +R S LAL QA + + L P E++ + T GD ILD L K+GGKGLFVK Sbjct: 3 TIKIGSRASQLALVQAEIIINMLKEKFPQYTYEIIKITTLGDRILDKTLDKIGGKGLFVK 62 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E++ AL E + D+A+HSMKD+P E P+ L L I +REDPRD ++ SL+ LP G++ Sbjct: 63 EIQKALAEEKIDLAIHSMKDMPGETPEELVLGAITKREDPRDVLITRENKSLEELPKGAV 122 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +G+SSLRRQ Q+ R D+ + +RGNVGTRL K++ D +ILA AGL RLGL+ +I Sbjct: 123 IGSSSLRRQAQVMALRGDIKVVPIRGNVGTRLGKIETESLDGVILAAAGLNRLGLKEKIS 182 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 + L E PAVGQGA+G E R D E+L A+NH ET V AERA LEGGC V Sbjct: 183 SYLEIEDFTPAVGQGALGCEARRKDIEMLEMLLAINHEETYRCVMAERAFLKLLEGGCHV 242 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 PIG+Y + E+ + +V + DG ++I+ + G D + +GI L E L+ GA+EIL Sbjct: 243 PIGAYGQQQGQELHMTGMVASSDGRRVIKEQVMGDIADFQALGIQLGETLIEKGAKEIL- 301 Query: 305 EVYNGD 310 E N D Sbjct: 302 ETVNTD 307 >UniRef50_Q2RJ26 Porphobilinogen deaminase n=5 Tax=Clostridia RepID=HEM3_MOOTA Length = 313 Score = 263 bits (673), Expect = 5e-69, Method: Compositional matrix adjust. Identities = 150/301 (49%), Positives = 193/301 (64%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +++ +R+S LA WQA +V L + PGL LV + T+GD ILD LA++G KGLF KE Sbjct: 4 IKVGSRESELARWQARWVIQALEKAWPGLSCRLVTLKTKGDKILDVALARIGDKGLFTKE 63 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE+ALL+ D+AVHSMKD+P P+GL + I REDP D VS +L LP + V Sbjct: 64 LELALLDGAIDLAVHSMKDMPTTLPEGLVIGAIGPREDPADVLVSPEGYTLATLPIKARV 123 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR+ QLA RPDL + LRGNV TRL+K++ AI+LA AGLKRL + Sbjct: 124 GTSSLRRKAQLAYARPDLELVDLRGNVPTRLAKMERDGLTAIVLAAAGLKRLNHGQVLGE 183 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 +P I LPAVGQGA+G+E R D R EL+AA+NH TA V AERA LEGGCQVP Sbjct: 184 PIPYHICLPAVGQGAIGVEIRAGDRRVAELVAAINHPPTAAAVRAERAYLRALEGGCQVP 243 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 I + A + D + L+ +V + DG +++R G+ +D E G LA +LL GA EIL E Sbjct: 244 IAALATVEDTALVLQGMVASLDGREMLRDIASGSTRDPEAAGRELARKLLARGAGEILQE 303 Query: 306 V 306 V Sbjct: 304 V 304 >UniRef50_A8PKX6 Porphobilinogen deaminase n=2 Tax=Gammaproteobacteria RepID=A8PKX6_9COXI Length = 311 Score = 262 bits (670), Expect = 1e-68, Method: Compositional matrix adjust. Identities = 152/301 (50%), Positives = 194/301 (64%), Gaps = 2/301 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 LRIATR+SPLA WQA +K++L P L + L+P VT GD + L + GGKGLFV Sbjct: 5 KFLRIATRKSPLAYWQATSIKNQLEKIFPFLKITLLPFVTEGDRPSHS-LNQWGGKGLFV 63 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE ALL +ADIAVHS+KD+P+ +GL L IC+R DPRD +S + LP GS Sbjct: 64 KELEAALLHGQADIAVHSLKDLPMTLEKGLVLGAICKRCDPRDVLISRSDRLFTQLPPGS 123 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGTSSLRRQ QL RPDL I LRGN+GTRL+KL GE+DAIILA AGL RL I Sbjct: 124 YVGTSSLRRQSQLLALRPDLKIGVLRGNIGTRLNKLAAGEFDAIILAAAGLIRLKKTECI 183 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + LPA GQGA+GIEC +D + ++AL H T V AERA++ L GGCQ Sbjct: 184 SEYFEIDHFLPAPGQGALGIECHENDEESLTYISALIHPITHSCVLAERALSRELGGGCQ 243 Query: 244 VPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 VP+ +YA + + I L+A VG+ DG+ I+ E++G +AE++G A++L G EI Sbjct: 244 VPLAAYAASLGQDFIRLQAFVGSSDGTTQIKVEKQGPRVEAEKIGFLAAQDLRALGVEEI 303 Query: 303 L 303 L Sbjct: 304 L 304 >UniRef50_D2R3S6 Porphobilinogen deaminase n=2 Tax=Planctomycetaceae RepID=D2R3S6_9PLAN Length = 311 Score = 258 bits (658), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 144/299 (48%), Positives = 192/299 (64%), Gaps = 2/299 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LR+ TR SPLA WQA +V+D+L+A+ G+ VE++ + T GD PL ++GG+GLF KE Sbjct: 7 LRLGTRASPLARWQADWVRDQLIAA--GIDVEMILITTEGDQQTSQPLGQIGGQGLFTKE 64 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 ++ LL D+AVHS+KD+P GL L + ERED D + SL LP+G+ + Sbjct: 65 IQRRLLAGDIDLAVHSLKDLPTLPIDGLSLAAVPEREDTADILIGPAGTSLATLPSGAKI 124 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT SLRR+ QL R DL I +RGNV TRL KLD G+Y AIILA AGLKRL L+ R+ Sbjct: 125 GTGSLRRKAQLLHARADLEILDIRGNVDTRLRKLDEGQYHAIILAAAGLKRLKLDDRMTE 184 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L + LPAVGQGA+GIE R DD TR+LLA L+H T V AER++ L GC P Sbjct: 185 RLEAPLMLPAVGQGALGIESRSDDPTTRKLLAPLSHAPTLQAVIAERSLLAALRAGCLAP 244 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 +G++A+++DG++ L A+V + DG + AP DA Q+G +AE L GA E+LA Sbjct: 245 VGAHAQVVDGQLTLAAVVLSIDGQSRLFASLTSAPADAAQLGEEVAELLRQQGATELLA 303 >UniRef50_A3ETN3 Porphobilinogen deaminase n=2 Tax=Leptospirillum sp. Group II RepID=A3ETN3_9BACT Length = 314 Score = 256 bits (655), Expect = 5e-67, Method: Compositional matrix adjust. Identities = 153/318 (48%), Positives = 196/318 (61%), Gaps = 17/318 (5%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 ML L+I +R S LALWQA +V L+ S G++ E+V + T GD+ILD L++VGGKG Sbjct: 1 MLPTPLKIGSRGSELALWQARHVA-SLIESVSGVLPEIVVIKTTGDIILDRQLSEVGGKG 59 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E ALL D+AVHSMKDVP P GL L REDPRD F+S +Y + +LP Sbjct: 60 LFVKEIEEALLRKEIDLAVHSMKDVPAFLPPGLTLAATLTREDPRDVFLSPHYPDIKSLP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 + VGTSSLRR Q+ E R DL LRGNVGTR+ K++ G DAIILA AGL RLG Sbjct: 120 QKARVGTSSLRRLAQIREIRNDLEFIPLRGNVGTRIRKMEEGVVDAIILAGAGLLRLGHA 179 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 +R+R + P + LPA+GQGA+G+E R DD T L+ +L+ T L V AER + L G Sbjct: 180 NRVREWISPRVLLPAIGQGALGLEIRTDDETTGTLVRSLSDESTHLSVAAERGVLQSLNG 239 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQI-IRGERRGAPQ---------DAEQMGISL 290 GCQVPI +YA +W + + +G + I G RR + DA QMGI L Sbjct: 240 GCQVPIAAYA------VWEKNRTLSLEGRVLDISGTRRIHARETRDIVTIDDAYQMGIDL 293 Query: 291 AEELLNNGAREILAEVYN 308 LL++GA EIL + Sbjct: 294 GNRLLSDGAEEILNSILK 311 >UniRef50_C8WXM9 Porphobilinogen deaminase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WXM9_ALIAD Length = 305 Score = 256 bits (654), Expect = 8e-67, Method: Compositional matrix adjust. Identities = 151/300 (50%), Positives = 196/300 (65%), Gaps = 2/300 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 LR+ATR+S LAL Q ++V D L G+ ELVP+ TRGD I+D L++VGGKGLFV Sbjct: 2 RTLRVATRRSALALTQTNHVVDLLKQVAHGVEFELVPIRTRGDEIVDRALSEVGGKGLFV 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 ++E AL +AD+AVHS+KDVP E GL + + REDPRDA +S L LP G+ Sbjct: 62 ADIEDALATGQADLAVHSLKDVPFELRDGLTIGAVPPREDPRDALISRTGQGLFDLPPGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGTSSLRRQ L RPDL + +LRGNV TRL +L+ G++DAI+LA +GL RLGL RI Sbjct: 122 RVGTSSLRRQAALRRLRPDLCVETLRGNVDTRLRRLEEGQFDAIVLAASGLHRLGLAERI 181 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 LP + +PAVGQGA+ IECR +D LAA+ + V AERA +RLEG CQ Sbjct: 182 TEYLPVDRFVPAVGQGALAIECRAEDDEVMRHLAAIADPDATRAVEAERAFLSRLEGSCQ 241 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 VPIG+YAE + E+ L A V P G ++ ER G +A +G+++AEE+L GA + L Sbjct: 242 VPIGAYAEPVGHELRLIAFVADPSGIHHLQLERTG--DEARALGVAMAEEMLRQGAEDWL 299 >UniRef50_A8LIJ6 Porphobilinogen deaminase n=11 Tax=Alphaproteobacteria RepID=A8LIJ6_DINSH Length = 347 Score = 254 bits (650), Expect = 2e-66, Method: Compositional matrix adjust. Identities = 144/294 (48%), Positives = 190/294 (64%), Gaps = 2/294 (0%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKG 60 D+ L+I TR S LAL QAH + +L A+ P E+V + T GD I D L+++GGKG Sbjct: 38 DSPLKIGTRGSLLALAQAHETRARLSAAFDLPEEAFEIVVIKTTGDRIQDRSLSEIGGKG 97 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF +E+E A+L+ DIAVHSMKD+PV+ P GL L T RED RDAFV+ + +L LP Sbjct: 98 LFTREIEDAMLDGSIDIAVHSMKDMPVDTPAGLALDTYLPREDVRDAFVTLDGGTLADLP 157 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G++VG+SSLRR+ QLA RRPDL + RGNV TR+ KL +G A LA+AGL RLG++ Sbjct: 158 EGAVVGSSSLRRRAQLAHRRPDLQLVEFRGNVQTRMKKLGDGVAHATFLAMAGLNRLGMD 217 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R+A+ PE LPAV QG +GIE R DD R E+LAA++ + R+ ERA + L+G Sbjct: 218 EVPRSAIAPEDMLPAVAQGCIGIERRADDPRAAEMLAAIHDGPSGHRLACERAYLSALDG 277 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 CQ PI AEL G I LRA + PDGS+++ +DA +MG +AE L Sbjct: 278 SCQTPIAGLAELDGGSIHLRAEILRPDGSEVLSDSETAPVEDAAKMGREVAERL 331 >UniRef50_Q65GK1 Porphobilinogen deaminase n=98 Tax=Bacillales RepID=HEM3_BACLD Length = 313 Score = 254 bits (649), Expect = 3e-66, Method: Compositional matrix adjust. Identities = 143/301 (47%), Positives = 187/301 (62%), Gaps = 4/301 (1%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67 + +R+S LA+ Q +V KL +P E+ +VT+GD ILD L+KVGGKGLFVKE+E Sbjct: 6 VGSRRSKLAMTQTKWVIKKLEELNPDFTFEIKEIVTKGDRILDVTLSKVGGKGLFVKEIE 65 Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127 A+L D+AVHSMKD+P P+GL + I +RED RD +S L L G++VGT Sbjct: 66 QAMLSGEIDMAVHSMKDMPSVLPEGLMVGCIPKREDARDVLISKGRQKLADLKQGAVVGT 125 Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR-IRAA 186 SSLRR QL + RPDL I+ +RGN+ TRL KL+ +YDAIILA AGL R+G + + Sbjct: 126 SSLRRSAQLLQMRPDLEIKWIRGNIDTRLKKLETEDYDAIILAAAGLSRMGWKDDVVTEF 185 Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246 L PE LPAVGQGA+ IECR D L + LN T L VTAERA +EGGCQVPI Sbjct: 186 LDPESCLPAVGQGALAIECRGSDEELLSLFSRLNDRYTQLTVTAERAFLHAMEGGCQVPI 245 Query: 247 GSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 +A++ DG I L LV +PDG + R +G +D E +G A + GA+ ++ Sbjct: 246 AGFAKMDEDGVIELTGLVASPDGKTVYRETVKG--KDPEAVGRECAAVMSEKGAKALIDR 303 Query: 306 V 306 V Sbjct: 304 V 304 >UniRef50_A6Q7Y4 Porphobilinogen deaminase n=7 Tax=Epsilonproteobacteria RepID=HEM3_SULNB Length = 323 Score = 253 bits (646), Expect = 6e-66, Method: Compositional matrix adjust. Identities = 136/306 (44%), Positives = 188/306 (61%), Gaps = 6/306 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L IATR S LALWQA+++K+++ + P + VEL + ++GD ILD PLA VGGKG F KE Sbjct: 4 LVIATRASNLALWQAYHIKERIETAFPEVRVELNEITSKGDKILDKPLALVGGKGHFTKE 63 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE ++ A +AVHS+KDVP P+GL L I ER+D D F+S+ Y SL LP G++V Sbjct: 64 LEDEMIAGNAHLAVHSLKDVPTYIPEGLELCAITERQDQSDVFLSHTYKSLSELPEGAVV 123 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT+SLRR+ QL E+RPDL ++ LRGNV TRL KL G+YDAIILA GL RL L I Sbjct: 124 GTTSLRRRMQLLEKRPDLKVKDLRGNVNTRLRKLKEGQYDAIILAYIGLYRLDLLKDIPY 183 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 + +P +GQ A+GIE ++ R RE+ LNH T + ER + + GC P Sbjct: 184 VEKLDFFIPPMGQAALGIEIVANNDRIREIAMTLNHEPTFICTKVERDFISVIGAGCSAP 243 Query: 246 IGSYAELIDGE------IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 + A + E I +RA++G PDG+ I+ +A+ +G LA+ ++ GA Sbjct: 244 VAVNATMDKKEDDKVPTISVRAMIGYPDGTHILHKSLTVPLNEADILGDELAQAMIEEGA 303 Query: 300 REILAE 305 +IL + Sbjct: 304 LDILEQ 309 >UniRef50_C9R7U0 Porphobilinogen deaminase n=1 Tax=Ammonifex degensii KC4 RepID=C9R7U0_AMMDK Length = 308 Score = 249 bits (637), Expect = 6e-65, Method: Compositional matrix adjust. Identities = 144/301 (47%), Positives = 186/301 (61%), Gaps = 1/301 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 LRI TR S LAL Q V L P E+V + T GD + + L ++GGKGLF Sbjct: 6 RCLRIGTRGSDLALAQTEQVLQILRERWPHYTYEIVKIKTTGDKVRNLALPRIGGKGLFT 65 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELEVALLE + D+AVHS+KD+P E P+ L + + RE P D +S L+ LP G+ Sbjct: 66 KELEVALLEEKIDLAVHSLKDLPTELPEELCVGAVLPREHPGDVLISLTGAGLEDLPEGA 125 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +GTSSLRRQ QL RPDL LRGNV TRL KL+ GE +A++LA AGL+RL L+ Sbjct: 126 RIGTSSLRRQAQLKAARPDLNFVPLRGNVPTRLRKLEKGECEAVVLAWAGLRRLRLDLTG 185 Query: 184 RAA-LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 R LP ++ LPAV QGA+G+E R +D R+++ L+ T L VTAERA L GGC Sbjct: 186 RMTLLPYQVCLPAVAQGAIGVEMRKEDRELRKMVEVLDDPTTRLEVTAERAFLRWLGGGC 245 Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 VPI + A + EI L LV P+G +I+RG+ G+ E++GI LAE LL GA E+ Sbjct: 246 HVPIAALARVAGAEILLEGLVADPEGKRIVRGQESGSTAYPEEVGIRLAERLLREGAEEL 305 Query: 303 L 303 L Sbjct: 306 L 306 >UniRef50_B2A1G7 Porphobilinogen deaminase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=HEM3_NATTJ Length = 311 Score = 249 bits (637), Expect = 6e-65, Method: Compositional matrix adjust. Identities = 137/309 (44%), Positives = 196/309 (63%), Gaps = 5/309 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LRI TR+S LAL Q ++V ++L +P + +E+ + T+GD +L+ L+KVGGKGLF+KE Sbjct: 3 LRIGTRRSQLALDQTNWVVEQLKTHYPDIEIEIKKIETKGDQLLNVSLSKVGGKGLFLKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 ++ ALL+ D+AVHSMKD+P E + L + I +R DP DA +SNN ++D LP + + Sbjct: 63 IQNALLQGEIDLAVHSMKDIPTETTEDLEICAITKRVDPLDALISNNDITIDELPENAKI 122 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESRIR 184 GTSSLRR QL R DL I +RGN+ TR++KL E DA++LA AGL R G+ I Sbjct: 123 GTSSLRRGSQLKAYRNDLQIIPIRGNINTRMNKLQELPELDAVVLAKAGLVRSGMTDSIS 182 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 + PEI +P GQGA+G+E R D+ +E LA L+ E+ + AERA RL G C V Sbjct: 183 QNISPEIIVPCPGQGALGLEIRHDNENLKEKLAVLDDSESRKAIGAERAFLNRLGGSCHV 242 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQ----MGISLAEELLNNGAR 300 P+G+YAE+I E+ L +V + DG +I+ + D + +G LAEEL+ GA Sbjct: 243 PVGAYAEIISNELHLTGVVASEDGQDVIKRSVQTHLSDNNKIPSTLGNDLAEELIELGAN 302 Query: 301 EILAEVYNG 309 +IL+E+ G Sbjct: 303 KILSELKEG 311 >UniRef50_Q4L709 Porphobilinogen deaminase n=88 Tax=Bacillales RepID=HEM3_STAHJ Length = 310 Score = 249 bits (635), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 139/303 (45%), Positives = 196/303 (64%), Gaps = 4/303 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L + +R+S LAL Q+ DKL A P L +E+ +VT+GD I++ L+KVGGKGLFVKE Sbjct: 4 LVVGSRRSKLALTQSQQFIDKLKAVDPTLEIEIKEIVTKGDRIVNKQLSKVGGKGLFVKE 63 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 ++ L + D+A+HS+KDVP P+GL L I +RE P DA++S N+ L+ LP GSI+ Sbjct: 64 IQQELFDKEIDMAIHSLKDVPSIIPEGLTLGCIPDREVPFDAYISKNHIPLNELPDGSII 123 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI-R 184 GTSSLRR Q+ + P+L I+ +RGN+ TRL KL+ +YDAIILA AGL+R+G I Sbjct: 124 GTSSLRRGAQILSKYPNLEIKWIRGNIDTRLKKLEIEDYDAIILAAAGLRRMGWSDDIVT 183 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L +I LPA+GQGA+GIECR DD ELL+ +++ A VTAER + ++G CQV Sbjct: 184 TYLDKDILLPAIGQGALGIECRSDDVELLELLSKVHNQAVANCVTAERTFLSAMDGSCQV 243 Query: 245 PIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 PIG YA +GEI L+ PDG++ R E ++ +G +++ L GA EI+ Sbjct: 244 PIGGYATNKENGEIEFTGLIMTPDGTK--RYEHTEVGKNPVDLGEAVSRVLKEQGAYEII 301 Query: 304 AEV 306 ++ Sbjct: 302 KKL 304 >UniRef50_Q43316 Porphobilinogen deaminase, chloroplastic n=61 Tax=cellular organisms RepID=HEM3_ARATH Length = 382 Score = 248 bits (633), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 138/300 (46%), Positives = 185/300 (61%), Gaps = 8/300 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLV----VELVPMVTRGDVILDTPLAKVGGKG 60 ++RI TR SPLAL QA+ ++KL HP LV + + + T GD IL PLA +GGKG Sbjct: 74 IIRIGTRGSPLALAQAYETREKLKKKHPELVEDGAIHIEIIKTTGDKILSQPLADIGGKG 133 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF KE++ AL+ DIAVHSMKDVP P+ L RED RDAF+ +L LP Sbjct: 134 LFTKEIDEALINGHIDIAVHSMKDVPTYLPEKTILPCNLPREDVRDAFICLTAATLAELP 193 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIR-SLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 AGS+VGT+SLRR+ Q+ + P L + + RGNV TRLSKL G+ A +LA+AGLKRL + Sbjct: 194 AGSVVGTASLRRKSQILHKYPALHVEENFRGNVQTRLSKLQGGKVQATLLALAGLKRLSM 253 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 + + L + LPAV QGA+GI CR DD + LA+LNH ET L ++ ERA L+ Sbjct: 254 TENVASILSLDEMLPAVAQGAIGIACRTDDDKMATYLASLNHEETRLAISCERAFLETLD 313 Query: 240 GGCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRG--APQDAEQMGISLAEELLN 296 G C+ PI YA +G R LV +PDG++++ R+G +D +MG +ELL+ Sbjct: 314 GSCRTPIAGYASKDEEGNCIFRGLVASPDGTKVLETSRKGPYVYEDMVKMGKDAGQELLS 373 >UniRef50_Q2S2A6 Porphobilinogen deaminase n=1 Tax=Salinibacter ruber DSM 13855 RepID=Q2S2A6_SALRD Length = 323 Score = 248 bits (632), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 145/308 (47%), Positives = 196/308 (63%), Gaps = 5/308 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + + L + TR S LAL QA+ V+ +L A+ G VEL + TRGD DTP++++G + + Sbjct: 3 ISDPLVLGTRGSELALRQANVVRSRLEAA--GHRVELETITTRGDEATDTPISEIGDEAV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN-NYDS-LDAL 119 F KEL+ ALL+ D+AVHS+KD+P P GL L I EREDPRDAFV++ ++D L L Sbjct: 61 FTKELDRALLQGGVDLAVHSLKDIPSTVPSGLALAAIGEREDPRDAFVAHPSFDGHLHDL 120 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P G+ V T+SLRR QL R DL + +RGNV TRL KL ++ ++LAVAGL RLGL Sbjct: 121 PEGATVATASLRRTAQLLTWRSDLEVVPVRGNVDTRLEKLGESDWTGMVLAVAGLVRLGL 180 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELL-AALNHHETALRVTAERAMNTRL 238 IR + P + +PAVGQGA+GI CR D R+LL L+H + AERA ++ Sbjct: 181 SLHIRDRIDPSLIVPAVGQGALGIACREDQDALRDLLRETLHHAPSGHAANAERAFLKKV 240 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GGCQVP+G++A + DG + L A + A DGS+ R ERR AP+D +G LA +LL G Sbjct: 241 GGGCQVPLGAWAHIDDGTLVLDACIAALDGSEHYRDERRCAPEDGAAVGRKLAADLLAMG 300 Query: 299 AREILAEV 306 IL +V Sbjct: 301 GDHILDDV 308 >UniRef50_P08397 Porphobilinogen deaminase n=59 Tax=Chordata RepID=HEM3_HUMAN Length = 361 Score = 244 bits (624), Expect = 2e-63, Method: Compositional matrix adjust. Identities = 145/332 (43%), Positives = 192/332 (57%), Gaps = 33/332 (9%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 V+R+ TR+S LA Q V L AS+PGL E++ M T GD ILDT L+K+G K LF K Sbjct: 20 VIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTK 79 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLDALPA 121 ELE AL +N D+ VHS+KD+P P G + IC+RE+P DA V + +L+ LP Sbjct: 80 ELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPE 139 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD-NGEYDAIILAVAGLKRLGLE 180 S+VGTSSLRR QL + P L RS+RGN+ TRL KLD E+ AIILA AGL+R+G Sbjct: 140 KSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQEFSAIILATAGLQRMGWH 199 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 +R+ L PE + AVGQGA+G+E R D +L+ L+ ET LR AERA LEG Sbjct: 200 NRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEG 259 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIR----------GERRGAPQD-------- 282 GC VP+ + + DG+++L V + DGS I+ + P+D Sbjct: 260 GCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIHVPAQHEDGPEDDPQLVGIT 319 Query: 283 -----------AEQMGISLAEELLNNGAREIL 303 A+ +GISLA LL+ GA+ IL Sbjct: 320 ARNIPRGPQLAAQNLGISLANLLLSKGAKNIL 351 >UniRef50_C3XEZ5 Porphobilinogen deaminase n=3 Tax=Campylobacterales RepID=C3XEZ5_9HELI Length = 328 Score = 244 bits (623), Expect = 3e-63, Method: Compositional matrix adjust. Identities = 147/311 (47%), Positives = 190/311 (61%), Gaps = 12/311 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L + TR S LALWQA+++K+KL G V L + T+GD ILD PLAK+GGKGLF KE Sbjct: 15 LVLGTRGSLLALWQANHIKEKL--ESLGFQVVLKTIKTKGDKILDAPLAKIGGKGLFTKE 72 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE LL D AVHS+KDVP+ P L LV+I +RED RD FVS Y + +LP G+ V Sbjct: 73 LENELLSGGIDFAVHSLKDVPIAIPPELMLVSITQREDARDCFVSEKYADIASLPQGAKV 132 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT+SLRR QL R DL +SLRGNV TRL KL GE+DAIILA AGL RL L+ I Sbjct: 133 GTTSLRRSMQLKRIRQDLDTQSLRGNVQTRLEKLRKGEFDAIILASAGLNRLDLKDDIGF 192 Query: 186 ALPPEIS--LPAVGQGAVGIECR-------LDDSRTRELLAALNHHETALRVTAERAMNT 236 +I+ +PA+GQG++GIECR D ++L +L+ ++AL ERA Sbjct: 193 ISHLQINQFIPAMGQGSLGIECRDPKYSPDFRDQAIMKVLESLHDSKSALCCNIERAFIQ 252 Query: 237 RLEGGCQVPIGSYAELIDG-EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295 L GGCQ PIG +A+++D EI ++ +VG D S+++ R + E + L Sbjct: 253 LLGGGCQSPIGIHAQILDSKEIEIQCVVGNLDASKVLTETRVCNKGEVEYALQDMINTLK 312 Query: 296 NNGAREILAEV 306 NG EIL EV Sbjct: 313 KNGVMEILEEV 323 >UniRef50_Q2LQU2 Porphobilinogen deaminase n=1 Tax=Syntrophus aciditrophicus SB RepID=HEM3_SYNAS Length = 306 Score = 244 bits (622), Expect = 4e-63, Method: Compositional matrix adjust. Identities = 131/304 (43%), Positives = 186/304 (61%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 ++I TR S LAL Q + +L +P + +E+V + T GD+ D PLAK+GGKGLF+KE Sbjct: 1 MKIGTRGSALALTQTRQIAARLQGQYPEMHLEIVVIKTSGDIQKDVPLAKIGGKGLFIKE 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E ALL D+AVHSMKD+P E P+GL + + REDPRD +S D LPAG+ + Sbjct: 61 IEEALLAGTVDLAVHSMKDLPAELPEGLQIAAVPRREDPRDVLISGICREFDNLPAGARI 120 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT SLRR QL + RPDL I LRGN+ TR+ K+ D +++A AG++R+G ++ Sbjct: 121 GTGSLRRSVQLRDWRPDLEIVPLRGNLDTRIRKVAQAALDGVVVAAAGIRRMGWAEKVTQ 180 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 +P E LPAVGQG + +E R +D + LA L T VTAERA RL GGC +P Sbjct: 181 FIPTEKMLPAVGQGVLCLETREEDEDLKAGLAFLEDKRTRREVTAERAFLRRLGGGCTLP 240 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 + ++AE + +R +VG+ + +IR E G+ + A +G LAE LL+ G R +L Sbjct: 241 VAAFAEQRGDVLTIRGMVGSLNERTMIRQEIYGSVEQAVDLGTELAERLLDGGGRILLEH 300 Query: 306 VYNG 309 + +G Sbjct: 301 LEDG 304 >UniRef50_Q54P93 Porphobilinogen deaminase n=1 Tax=Dictyostelium discoideum RepID=HEM3_DICDI Length = 325 Score = 240 bits (613), Expect = 4e-62, Method: Compositional matrix adjust. Identities = 132/311 (42%), Positives = 190/311 (61%), Gaps = 12/311 (3%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67 I +R+S LA+ Q +V+D++ +PG++VE+ M T GD +LD L+K+G KGLF KELE Sbjct: 12 IGSRKSQLAMLQTEWVRDRIQELNPGIIVEIKTMDTTGDKVLDVSLSKIGDKGLFTKELE 71 Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD-----SLDALPAG 122 +L D+AVHS+KD+P + P GL L I +R + DAF++N L LP G Sbjct: 72 DMMLNGTIDLAVHSLKDIPTKLPDGLKLGAITKRYNTSDAFIANAKKHGKNCKLSELPQG 131 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--DNGEYDAIILAVAGLKRLGLE 180 +++G+SSLRR QL + P L + +RGN+ TR KL D+ YD +ILAVAGL+R+ L Sbjct: 132 AMIGSSSLRRVAQLKKAYPHLQFKDIRGNLNTRFKKLEDDSNGYDGMILAVAGLERMELT 191 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 I +P ISL AVGQG++GIEC+ D + +L L H E+ AER+M LEG Sbjct: 192 DHISEIIPDSISLYAVGQGSLGIECKDGDDFIQSILNPLIHRESMYCCEAERSMLRDLEG 251 Query: 241 GCQVPIGSYAELI-----DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295 GC VPIG +L D + + A+V DGS+ I + G Q+G S+A++L+ Sbjct: 252 GCHVPIGVVTKLHNQSQPDETLEINAIVLNLDGSKYIESKIIGPSIQYYQLGKSIAQDLI 311 Query: 296 NNGAREILAEV 306 N G+++IL+E Sbjct: 312 NKGSKDILSEF 322 >UniRef50_B2S842 Porphobilinogen deaminase n=38 Tax=Rhizobiales RepID=HEM3_BRUA1 Length = 314 Score = 236 bits (602), Expect = 7e-61, Method: Compositional matrix adjust. Identities = 134/294 (45%), Positives = 170/294 (57%), Gaps = 2/294 (0%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKG 60 + L+I TR S LAL QA+ + L +H P +E++PM T GD I D PL++VGGKG Sbjct: 8 NGTLKIGTRGSKLALAQAYLTRRLLQEAHGLPEDAIEILPMSTAGDRIQDRPLSEVGGKG 67 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF +E+E AL + R DIAVHS KD+P P+GL L EREDPRDAF+ + LP Sbjct: 68 LFTEEIEQALKDGRIDIAVHSTKDMPTALPEGLHLSVFLEREDPRDAFIGRSARRFMDLP 127 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VG+SSLRRQ + RPD+ + RGNV TRL KLD GE D LA AGL+RLGL Sbjct: 128 QGATVGSSSLRRQALIRRLRPDIEVVMYRGNVDTRLRKLDAGEVDGTFLACAGLRRLGLA 187 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 I L P + PA GQGA+GIE R+ D R LLA L H ET + + ERA L+G Sbjct: 188 DVITDVLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERAFLGALDG 247 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 C+ PI A + + R ++ PDG Q G DA +G A + Sbjct: 248 SCRTPIAGLATVEGDRLSFRGMILTPDGRQAHEVTAEGVVSDAAALGTDAANRV 301 >UniRef50_A6WXJ2 Porphobilinogen deaminase n=56 Tax=cellular organisms RepID=HEM3_OCHA4 Length = 314 Score = 236 bits (602), Expect = 8e-61, Method: Compositional matrix adjust. Identities = 132/294 (44%), Positives = 172/294 (58%), Gaps = 2/294 (0%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKG 60 + L+I TR S LAL QA+ + +LM +H P +E++PM T GD I D L+++GGKG Sbjct: 8 NGTLKIGTRGSKLALAQAYETRRRLMEAHGLPEEAIEIIPMSTAGDRIQDRALSEIGGKG 67 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF +E+E AL + R D+AVHS KD+P P GL L EREDPRDAF+ L LP Sbjct: 68 LFTEEIEQALTDGRIDLAVHSTKDMPTVLPDGLHLSVFLEREDPRDAFIGRTASRLLDLP 127 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VG+SSLRRQ + RPD+ + RGNV TRL KL+ GE D LA AGL+RLGL Sbjct: 128 QGATVGSSSLRRQALIRRLRPDIQVVIFRGNVDTRLRKLEAGEVDGTFLACAGLRRLGLG 187 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 I PE PA GQGA+GIE R+ D+R LLA L H ET + + ERA L+G Sbjct: 188 DVITDLADPESFPPAPGQGAIGIETRIGDTRIDTLLAPLAHRETGIALACERAFLAALDG 247 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 C+ PI A + + ++ PDGS+ + G +A +G AE L Sbjct: 248 SCRTPIAGLATVNGDTVSFHGMILKPDGSEAHEIKTEGPASNAAAIGTEAAEHL 301 >UniRef50_A6GB01 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=A6GB01_9DELT Length = 322 Score = 231 bits (588), Expect = 3e-59, Method: Compositional matrix adjust. Identities = 140/304 (46%), Positives = 182/304 (59%), Gaps = 6/304 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 LR+ TR S LALWQA+ ++D+L+A+ GL VELV +VT+GD + D PL +VGG GLFV Sbjct: 11 LRLGTRGSALALWQANMIRDRLLAAWGAQGLEVELVRVVTKGDRVTDRPLNQVGGMGLFV 70 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS--NNYDSLDALPA 121 K LE LL D AVHSMKD+P P+GL L + ER DPRDAF++ +L LPA Sbjct: 71 KGLEDKLLAGEIDFAVHSMKDMPGTLPEGLTLASTPERADPRDAFLAAPGRDVTLATLPA 130 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 GS +GTSSLRR P L I +RGNV TR+ K+ GE DA++LA AGL RLG Sbjct: 131 GSRLGTSSLRRGALAKRINPGLEIVPIRGNVPTRMGKIAEGEVDAVLLAAAGLDRLGKGE 190 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 I L P+ +PA QG + IE R D+ L L H T++ AER+ L+GG Sbjct: 191 AITERLDPDAFMPAACQGVLAIELRAADTDIAALFEPLGHGPTSIVAAAERSYLATLQGG 250 Query: 242 CQVPIGSYAELI-DG-EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 CQVP+ +A L DG + + LV PDGS + E G DA Q+G +A E+L G Sbjct: 251 CQVPLACHARLSEDGRRVRVEGLVVEPDGSTVYASEAEGPVADAAQLGAGVAREVLAAGG 310 Query: 300 REIL 303 + ++ Sbjct: 311 QGVI 314 >UniRef50_A3ZKX4 Porphobilinogen deaminase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A3ZKX4_9PLAN Length = 308 Score = 231 bits (588), Expect = 4e-59, Method: Compositional matrix adjust. Identities = 134/301 (44%), Positives = 185/301 (61%), Gaps = 5/301 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LA WQA++V D+L A G VE++ + T+GDV PL +GG+G+F E Sbjct: 4 IRIGTRGSQLAQWQANWVADQLRAV--GTDVEIIHIATQGDVT-QGPLDLIGGRGVFTTE 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 ++ ALL+NR D+AVHS+KD+P E GL L + R D +++ + LP SI+ Sbjct: 61 IQAALLDNRIDVAVHSLKDLPTEAVVGLRLAAVPARGADGDVLITSKASDVLGLPQESII 120 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT S+RR+ QL R D IR +RGN+ TRL KLD+G YDAIILA AGL+RL L RIR Sbjct: 121 GTGSMRRKAQLLHLRRDFQIRDIRGNLDTRLRKLDDGLYDAIILAEAGLRRLELIERIRH 180 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 +P LPAVGQGA+G+E R DS T +LA LNH ++ V AER+M L GGC P Sbjct: 181 VIPKAQMLPAVGQGALGLEIRERDSATAAMLAPLNHEDSHYSVLAERSMLRNLRGGCLAP 240 Query: 246 IGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 +G++ + I ++L +V + DG + G P AE +G +A++L GA ++ Sbjct: 241 VGAWGRIDPIKQLLFLDGVVVSGDGHHKVTASACGPPNRAEDIGRQVADQLAIQGAERLI 300 Query: 304 A 304 A Sbjct: 301 A 301 >UniRef50_C8WIZ2 Porphobilinogen deaminase n=2 Tax=Coriobacteriaceae RepID=C8WIZ2_EGGLE Length = 327 Score = 230 bits (586), Expect = 5e-59, Method: Compositional matrix adjust. Identities = 138/314 (43%), Positives = 183/314 (58%), Gaps = 13/314 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LALWQAH+V D L A+ PG+ V + + T+GD IL L+K+G KGLF KE Sbjct: 4 MRIGTRGSKLALWQAHHVADLLRAASPGMDVSVEVVKTKGDRILGVALSKIGDKGLFTKE 63 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE AL + R D+ VHSMKDVP P+GL L R D RD V+ + + LPAGS V Sbjct: 64 LEQALFDGRVDVCVHSMKDVPTALPEGLALAGCLIRADARDVLVAASGTTFAGLPAGSRV 123 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT +LRR QL R DL +RGN+ TR++K+ +G DA++LA AG++R+G + + Sbjct: 124 GTGALRRLSQLRAVRDDLDYVEVRGNLDTRIAKVRDGALDAVVLAAAGIERMGWSAEVAE 183 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 A + +PAVGQGA+G+E R DD RT A + T V AER + L+GGCQVP Sbjct: 184 AFSVDTVVPAVGQGAIGLEVRADDERTARACAQVRCAATDACVAAERHVMRALDGGCQVP 243 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ-------------DAEQMGISLAE 292 IG+YA +G + L A VG+ DGS ++R A Q +A + E Sbjct: 244 IGAYARYEEGLLVLDAFVGSLDGSHVLRSRLSAASQPPNDTDAVEAAVREARALAQRAVE 303 Query: 293 ELLNNGAREILAEV 306 E GAR +L V Sbjct: 304 EFEAQGARAVLDAV 317 >UniRef50_UPI0000583C22 PREDICTED: hypothetical protein n=1 Tax=Strongylocentrotus purpuratus RepID=UPI0000583C22 Length = 324 Score = 229 bits (584), Expect = 1e-58, Method: Compositional matrix adjust. Identities = 131/313 (41%), Positives = 185/313 (59%), Gaps = 21/313 (6%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 ++R+ +R+S LA+ Q ++V + L HP ++V M T GD I D PLA +G LF K Sbjct: 7 IVRVGSRKSELAMIQTNHVVEMLQKVHPETEFKIVTMETIGDHIQDKPLASIGESNLFTK 66 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLDALPA 121 ELE AL + D+ VHS+KD+P P + + ICEREDP DA V + S++ + Sbjct: 67 ELEKALALDEVDMLVHSLKDMPSRLPSNMAIGAICEREDPHDALVLHKKLTGISIETMKE 126 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-YDAIILAVAGLKRLGLE 180 GS++GTSS+RR QL + P L+ + +RGN+ TRL KLD G+ YD ++LAVAG+ R+G E Sbjct: 127 GSVLGTSSVRRVAQLKRKFPHLVFKDVRGNLNTRLRKLDEGQVYDGLVLAVAGMMRMGWE 186 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 RI L P+I +V QGA+GIE + + R ELL LNH T +R AER + LEG Sbjct: 187 HRISQILKPDICKYSVSQGALGIEIKTKNRRMHELLRQLNHVPTLIRCIAERGLLKTLEG 246 Query: 241 GCQVPIGSYAEL----------IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISL 290 GC P+ ++EL + E+ L + V AP SQ A Q+AE +G+S+ Sbjct: 247 GCSAPVAVHSELEENRHSLDAETNEEMKLFSSVIAPWVSQ-------HAMQEAEALGVSV 299 Query: 291 AEELLNNGAREIL 303 A+ L + GA IL Sbjct: 300 AKGLFDKGAGPIL 312 >UniRef50_A7BMK1 Porphobilinogen deaminase n=1 Tax=Beggiatoa sp. SS RepID=A7BMK1_9GAMM Length = 211 Score = 228 bits (581), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 124/209 (59%), Positives = 149/209 (71%), Gaps = 1/209 (0%) Query: 101 REDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD 160 RE+P DAFVSN Y +L ALP G+IVGTSSLRRQ QL RPDL IRSLRGNVGTRLSKLD Sbjct: 3 REEPFDAFVSNTYATLAALPEGAIVGTSSLRRQSQLLAHRPDLQIRSLRGNVGTRLSKLD 62 Query: 161 NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALN 220 NG+YDAI+LA GLKRLGL RIR + I LPA+GQGA+GIECR DD TR+ + LN Sbjct: 63 NGDYDAIVLAAVGLKRLGLVERIREIIDSTIMLPAIGQGAIGIECRQDDLETRQHIDNLN 122 Query: 221 HHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGA 279 +T V AERA+N LEGGCQVPI YAE+ E + +R LVG +G I+R +GA Sbjct: 123 DPDTQDCVIAERALNESLEGGCQVPIAGYAEIQSSENLTMRGLVGDIEGQHILRHNLQGA 182 Query: 280 PQDAEQMGISLAEELLNNGAREILAEVYN 308 A ++G SLA+ LL GA +IL ++ + Sbjct: 183 RHLAAELGKSLAKVLLTQGAAQILEKLKD 211 >UniRef50_C1ZK04 Porphobilinogen deaminase n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZK04_PLALI Length = 318 Score = 228 bits (581), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 140/315 (44%), Positives = 182/315 (57%), Gaps = 16/315 (5%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 VLRIATR S LALWQA++V D L + P L VELV + T GD + PL + GG+G+F + Sbjct: 3 VLRIATRASQLALWQANFVADSLRSLDPELTVELVHVTTTGDRVQGEPLRQFGGQGVFTR 62 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV----SNNYDSLDALP 120 E++ ALLE RADIAVHS+KD+P GL L + R DA + + SL LP Sbjct: 63 EVQAALLEGRADIAVHSLKDLPTVPTAGLELAAVPARAPVADALLLPTGHSGPASLAMLP 122 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GT S RRQ QL RPDL+ +RGN+ TR+ KLD GEY+ +ILAVAGL RLG Sbjct: 123 RGARIGTGSPRRQAQLLRIRPDLVCSEVRGNLDTRIRKLDAGEYEGLILAVAGLSRLGWS 182 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 RI L P PA GQGA+G+ECR D T ++ L +T L V AERA+ LE Sbjct: 183 DRISLILAPPTMFPAAGQGALGLECRHGDEATIRWVSQLEDRQTRLAVDAERAVLRTLEA 242 Query: 241 GCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERR-----------GAPQDAEQMGI 288 GC P+G++A E + L A++ APDGS+ + A A ++G Sbjct: 243 GCHAPVGTWASWKSPETLHLEAILIAPDGSETLAAASSMQGPLSQYGSGNALDAAHELGA 302 Query: 289 SLAEELLNNGAREIL 303 ++A LL GA L Sbjct: 303 NVAHLLLKQGASRYL 317 >UniRef50_C1AA38 Porphobilinogen deaminase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1AA38_GEMAT Length = 309 Score = 227 bits (579), Expect = 4e-58, Method: Compositional matrix adjust. Identities = 154/313 (49%), Positives = 189/313 (60%), Gaps = 12/313 (3%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M+ +RI TR S LAL QA V +L A G+ ELV T GD ILD PL+ +G KG Sbjct: 1 MMTVPVRIGTRSSELALRQARQVAAQLDAR--GVPSELVEYTTLGDRILDRPLSAIGEKG 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLD 117 LF ELE LL R D AVHS+KD+P PQG+ +V + EREDPRDA V + SLD Sbjct: 59 LFTAELEADLLAGRIDCAVHSLKDLPTADPQGIIVVALLEREDPRDALVVRAGVDAHSLD 118 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177 LP G+ VGTSSLRR+ QL R DL + LRGNVGTRL KLD G+ DA +LA AGL RL Sbjct: 119 TLPEGARVGTSSLRRRAQLQALRSDLEVCELRGNVGTRLRKLDEGQVDAALLAAAGLHRL 178 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 GL RI A L L A GQGA+ ++ R DD L++L+H T + VTAERA+ Sbjct: 179 GLADRIVAYLDAPEWLSAPGQGAIAVQGRADDEALLSTLSSLDHAPTRVAVTAERALLAA 238 Query: 238 LEGGCQVPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQ---MGISLAEE 293 LEGGCQVPIG+ E + L A++ + DGS +RG G P D GI LA + Sbjct: 239 LEGGCQVPIGAAVLEEPEYGTILHAVIVSLDGSSAVRG---GYPVDHANPAASGIELARQ 295 Query: 294 LLNNGAREILAEV 306 L G +IL+E+ Sbjct: 296 LRAAGGAQILSEI 308 >UniRef50_UPI00017922DC PREDICTED: similar to porphobilinogen deaminase n=1 Tax=Acyrthosiphon pisum RepID=UPI00017922DC Length = 377 Score = 225 bits (574), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 122/276 (44%), Positives = 163/276 (59%), Gaps = 22/276 (7%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +R+ +R+S LAL Q +V +L HP + E+V M T GD +LD PL K+G K LF Sbjct: 7 KTIRVGSRKSELALIQTKFVISQLKELHPEIEFEIVSMTTMGDRVLDKPLPKIGEKSLFT 66 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV----SNNYDSLDAL 119 K+LEVALL D VHS+KD+P G + I +R+DPRDA V Y LD+L Sbjct: 67 KDLEVALLSGTVDFIVHSLKDLPTVMEIGTTIGAILKRDDPRDALVLRDDCKEY-QLDSL 125 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD---------NGEYDAIILA 170 P+ S +GTSSLRR QL + P+L + +RGN+ TRL KLD N Y IILA Sbjct: 126 PSKSFIGTSSLRRTAQLKRKFPNLQVSDVRGNLNTRLKKLDSSQSTGDNTNTNYSGIILA 185 Query: 171 VAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTA 230 +AG++R+G E R+ + ++ L AVGQGA+ +ECRL D E+L L+H+ET L+V A Sbjct: 186 LAGIQRMGWEKRVSQIIDSDVMLYAVGQGALAVECRLGDDYILEMLEPLHHYETVLQVVA 245 Query: 231 ERAMNTRLEGGCQVPIG--------SYAELIDGEIW 258 ER TRL GGC P+G A +DG +W Sbjct: 246 ERGFLTRLGGGCSAPVGIRSTVCLTKNAMSLDGAVW 281 >UniRef50_Q1J288 Porphobilinogen deaminase n=5 Tax=Deinococci RepID=HEM3_DEIGD Length = 309 Score = 224 bits (570), Expect = 4e-57, Method: Compositional matrix adjust. Identities = 131/304 (43%), Positives = 183/304 (60%), Gaps = 5/304 (1%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGD---VILDTPLAKVGGKGLFVK 64 + TR S LAL Q +V +L P + + T+GD L + LA+ G KG +VK Sbjct: 6 VGTRGSALALAQTRWVVARLKEEWPDTDFRIQTISTKGDRDRAALQS-LAQKGDKGFWVK 64 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALPAGS 123 E+E ALL R DIAVHS+KD+P E P+GL + +I +R D RD + + L+ LP+G+ Sbjct: 65 EIEDALLAGRIDIAVHSLKDLPTEQPEGLEIASIPKRVDARDVLIGKDGMKRLEDLPSGA 124 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGTSS+RR+ L RPDL I LRGN+ TRL+ L +YDAI+LA AGL R + RI Sbjct: 125 RVGTSSVRRKAFLRAYRPDLQILDLRGNIDTRLAALGTPDYDAIVLAAAGLIRTEMRHRI 184 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + P++ LPA GQGA+ +E R DD + E++ A++ H T RVTAER L GC Sbjct: 185 DEFIDPDLLLPAPGQGALALETRADDDLSIEVVYAIHDHATDDRVTAEREFLAGLGAGCM 244 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 P+G++A L DG + L VGA DGSQ+IR G P + +G LA ++L GA++++ Sbjct: 245 APVGAHATLKDGVLTLEGWVGALDGSQVIRATTSGDPAECADLGAELAADMLGQGAQQLI 304 Query: 304 AEVY 307 + Sbjct: 305 EAAH 308 >UniRef50_A8U3E9 Porphobilinogen deaminase n=1 Tax=alpha proteobacterium BAL199 RepID=A8U3E9_9PROT Length = 321 Score = 222 bits (566), Expect = 1e-56, Method: Compositional matrix adjust. Identities = 131/306 (42%), Positives = 178/306 (58%), Gaps = 7/306 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLV--VELVPMVTRGDVILDTPLAKVGGKGLFV 63 L + +R SPLAL Q H V+D+L A+ P L + + + T GD + D PLA++GGKGLF+ Sbjct: 15 LTLGSRGSPLALRQTHEVRDRLAAAWPELAGAIAVQEIRTTGDAVRDRPLAEIGGKGLFI 74 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE+E AL+ + D AVHSMKD+ LV + REDPRDA++S D +D LP+G+ Sbjct: 75 KEIEQALMAGQIDAAVHSMKDMETTIAPASVLVAVLPREDPRDAWLSPIADRVDDLPSGA 134 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +GT+S+RR Q+ RRPDL + RGNV TRL KL GE LA AGL RLG+ + Sbjct: 135 KIGTASVRRAAQVLNRRPDLQVVLFRGNVDTRLRKLAEGEVAGTFLAAAGLSRLGMLDKA 194 Query: 184 RAALPPEISLPAVGQGAVGIECR-----LDDSRTRELLAALNHHETALRVTAERAMNTRL 238 L + LPAV QGA+G++CR D+ R L+ L+ + LRVTAERAM L Sbjct: 195 TRILEVDEMLPAVSQGAIGVQCRDGEASARDAEIRNWLSILDDRPSRLRVTAERAMLATL 254 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 +G C+ PI +A L + L +V + DG A D E +G ++ E +L G Sbjct: 255 DGSCRTPIAGHATLGGARLTLSGMVFSLDGQSSHGAVDTSATDDPEALGRTVGEAILARG 314 Query: 299 AREILA 304 R LA Sbjct: 315 GRNFLA 320 >UniRef50_A6DBT5 Porphobilinogen deaminase n=1 Tax=Caminibacter mediatlanticus TB-2 RepID=A6DBT5_9PROT Length = 295 Score = 222 bits (566), Expect = 1e-56, Method: Compositional matrix adjust. Identities = 132/293 (45%), Positives = 177/293 (60%), Gaps = 8/293 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L IATR S LALWQA +VK +L + G V+L + T GD ILD PLA +GGKGLF+KE Sbjct: 3 LTIATRGSKLALWQAEWVKKRL--ENLGHEVDLKIVTTTGDKILDKPLASIGGKGLFIKE 60 Query: 66 LEVALLENRADIAVHSMKDVPVEF-PQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 +E ALL A IAVHS+KD P E+ + L + +RE D F+S +++L LP ++ Sbjct: 61 VEEALLRGEAQIAVHSLKDFPTEYNKEHFTLAAVPKREAVEDVFLSETFETLAELPHNAV 120 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL--ESR 182 VGTSS+RR QL R DL+I LRGNV TR++KL GEYDAIILA AG+KRL L E + Sbjct: 121 VGTSSIRRAMQLKAFREDLVISDLRGNVDTRINKLKKGEYDAIILAYAGVKRLNLIKEVK 180 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 L +I +PA+GQGA+GIE + D + E + LN T + VT ER L GC Sbjct: 181 YFEILDTDIMIPAMGQGALGIET-IKDEKVIEAVKPLNDLWTKIEVTIERDFIDELNLGC 239 Query: 243 QVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 P+G A+ ++D I ++A + +++I+ E + E G AEE Sbjct: 240 HAPVGVNAKIMVDDSIKIKAAI-LDKNNKVIKKEMVVPFDEWENAGREFAEEF 291 >UniRef50_A3CL78 Porphobilinogen deaminase n=1 Tax=Streptococcus sanguinis SK36 RepID=HEM3_STRSV Length = 306 Score = 219 bits (559), Expect = 7e-56, Method: Compositional matrix adjust. Identities = 126/300 (42%), Positives = 180/300 (60%), Gaps = 7/300 (2%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 V+++ TR+S LA+ Q + D+L A HP LVP T+GD + L ++GGKG+FV Sbjct: 2 KVIKVGTRKSKLAMTQTQQLVDQLKALHPERDFVLVPYTTKGDRLTHVSLQEIGGKGVFV 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALPAG 122 KE+E ALL ++AVHS+KD+P + +G L I +RED RD + +L LP G Sbjct: 62 KEIERALLAGEINMAVHSLKDMPAKLAEGCALGAISQREDVRDCLIFRQAGQTLADLPKG 121 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 S++GTSS+RRQ QL +RPDL + LRGN+ TR+ KL+ GEYDAI+LA+AGLKRLG + Sbjct: 122 SLIGTSSIRRQVQLQAQRPDLAFKPLRGNIDTRIKKLEEGEYDAIVLAMAGLKRLGWLDQ 181 Query: 183 IRAALPP---EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 R + P + LPA+ QGA+ +ECR +D LLAA+ +TA V ERA+ ++ Sbjct: 182 SRLHIQPLETSLCLPAISQGALAVECREEDEELLSLLAAVQDEKTAAEVAVERAVLAQMN 241 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 C PI ++A+ L A++ DG Q I +G QD +Q+ +L + GA Sbjct: 242 ADCTFPIAAFAQKNGQGYQLEAMLAKEDG-QCIFVSLQG--QDGQQLAEQAVRQLADKGA 298 >UniRef50_C1F251 Hydroxymethylbilane synthase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F251_ACIC5 Length = 312 Score = 219 bits (559), Expect = 7e-56, Method: Compositional matrix adjust. Identities = 124/255 (48%), Positives = 158/255 (61%), Gaps = 6/255 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKV----GGKG 60 ++RI +R S LALWQA+++ +L + +E++ T GD + AKV GGKG Sbjct: 1 MMRIGSRGSQLALWQANHIAARLRTLGHEVTIEIIR--TTGDALQHVTFAKVSTELGGKG 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 +F KE+E AL E R D+AVHS+KD+P + L I ER DPRDA +S Y SL +LP Sbjct: 59 IFTKEIEEALREGRIDLAVHSLKDLPTDLDPAFTLAAIPERVDPRDALLSARYTSLASLP 118 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGTSS RR+ QL R DL + RGNV TR+ K+ G+ DAIILA AGL+RLGL Sbjct: 119 HGACVGTSSERRRAQLLVHRSDLRFQEFRGNVDTRIRKMVEGQADAIILASAGLERLGLT 178 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R L PEI PA GQGA+ IE R DD+ T +LA+L+H T VTAER L G Sbjct: 179 EYRRECLAPEILCPAAGQGALAIETRADDAETLAILASLDHSATRYAVTAERTALASLGG 238 Query: 241 GCQVPIGSYAELIDG 255 GCQVPIG + + G Sbjct: 239 GCQVPIGIHCAPVPG 253 >UniRef50_O94048 Porphobilinogen deaminase n=53 Tax=Saccharomyceta RepID=HEM3_CANAL Length = 340 Score = 217 bits (552), Expect = 5e-55, Method: Compositional matrix adjust. Identities = 132/318 (41%), Positives = 189/318 (59%), Gaps = 17/318 (5%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 N ++I R+S LA+ Q+ VK + + P L ++ + T GD + PL GGK L+ Sbjct: 12 NHVQIGGRKSKLAVVQSEIVKKVIEDTFPNLSCSILALSTLGDKVQTQPLYTFGGKSLWT 71 Query: 64 KELEVALLEN-----RADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDS 115 KELE+ LL++ + D+ VHS+KD+P P+ L I +REDPRDA V ++Y S Sbjct: 72 KELEILLLDSVDEFPKLDLIVHSLKDMPTNLPEEFELGCIFQREDPRDAIVMKQGSSYKS 131 Query: 116 LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAG 173 L LPAG+IVGTSS+RR QL + P L S+RGN+ TRL+KLD N EY +ILA AG Sbjct: 132 LKDLPAGAIVGTSSIRRSSQLIKNYPHLRFESVRGNIQTRLNKLDQPNNEYCCLILASAG 191 Query: 174 LKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERA 233 L RLGL RI + L + AVGQGA+GIE R D + +L + + AER+ Sbjct: 192 LIRLGLGHRITSYL--DDMYYAVGQGALGIEIRKGDDNIKSILKKIEDPIATICCLAERS 249 Query: 234 MNTRLEGGCQVPIGSYAELIDG--EIWLRALVGAPDGSQIIRGE---RRGAPQDAEQMGI 288 + LEGGC VP+G +++ + E+ L+ ++ +PDG+ I E R +D EQ+GI Sbjct: 250 LMRYLEGGCSVPLGVHSDYNESKQELTLKGIIVSPDGTVSIEDEVIKRITCDEDCEQVGI 309 Query: 289 SLAEELLNNGAREILAEV 306 L ++L GA+EIL ++ Sbjct: 310 ELGDKLKAKGAKEILDKI 327 >UniRef50_C7NFP7 Hydroxymethylbilane synthase n=7 Tax=Actinomycetales RepID=C7NFP7_KYTSD Length = 358 Score = 215 bits (548), Expect = 1e-54, Method: Compositional matrix adjust. Identities = 126/268 (47%), Positives = 167/268 (62%), Gaps = 3/268 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 V+R+ TR+S LA Q+ +V D L A G VELV + T GDV PL+++GG G+FV Sbjct: 15 VVRLGTRRSDLATTQSTHVADALRAR--GHEVELVLVTTEGDVN-RAPLSRIGGTGVFVS 71 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L ALL DIAVHS+KD+PV PQ L + + EREDPRDA V+ + +L+ LPAG+ Sbjct: 72 ALRDALLAGEIDIAVHSLKDLPVAQPQELVIAAVPEREDPRDALVARDGLTLETLPAGAR 131 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGT S RR+ QL RPDL + LRGNV RL+ + GE DA++LA AGL+RLGL + Sbjct: 132 VGTGSPRREAQLRVARPDLEVVDLRGNVPRRLATVAEGELDAVVLAGAGLRRLGLTEHVT 191 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L P++ +PA GQGA+ +ECR DD+ + +L L+H T TAERA+ LE GC Sbjct: 192 QWLEPQVMVPAPGQGALAVECRSDDAESIAMLEPLDHLPTRTATTAERAVLGTLEAGCSA 251 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQII 272 PIG+ A + L G DGS+ + Sbjct: 252 PIGALARHDGARVDLMTFAGPRDGSRAL 279 >UniRef50_Q0TQG4 Porphobilinogen deaminase n=32 Tax=Clostridium RepID=HEM3_CLOP1 Length = 291 Score = 214 bits (545), Expect = 3e-54, Method: Compositional matrix adjust. Identities = 129/290 (44%), Positives = 172/290 (59%), Gaps = 4/290 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L IATR+S LA Q V + L+ + + + ++T GD LD L K+GGKGLFVKE Sbjct: 3 LIIATRKSKLAQVQTEKVME-LLKEKENVDSKKLLVMTEGDRRLDVSLNKIGGKGLFVKE 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E+ALL A AVHSMKDVP E P LV + ERED RDAFVS N +L L G+ + Sbjct: 62 IELALLNKEAHGAVHSMKDVPFELPSEFELVAMPEREDIRDAFVSLNGSTLSNLRKGARI 121 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR QL R DL I +RGNV TR+ K+ D IILA AGLKRLG+E I Sbjct: 122 GTSSIRRAEQLKLFRDDLEIVPIRGNVQTRIKKITEENLDGIILAAAGLKRLGMEDVISD 181 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 P++ LPA+GQGA+GIEC L + AL+ E V AER+ L GGC Sbjct: 182 YFDPKVFLPAIGQGALGIEC-LKGGEFNDYFKALDSKEVRTTVEAERSFMKVLNGGCHSL 240 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295 IG+Y+E+ D ++++ ++I++ + G +D +G LAE++L Sbjct: 241 IGAYSEVKDNDLYMIGTFTV--NNRIVKKDILGNKEDNILLGKKLAEKIL 288 >UniRef50_Q3YSA8 Porphobilinogen deaminase n=17 Tax=Rickettsiales RepID=HEM3_EHRCJ Length = 298 Score = 214 bits (544), Expect = 4e-54, Method: Compositional matrix adjust. Identities = 112/292 (38%), Positives = 177/292 (60%), Gaps = 3/292 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LAL Q V + L P + +++V + T GD+ P+ +GGKGLF+KE Sbjct: 3 IRIGTRGSVLALAQTLEVTNLLNRYFPEINIQVVKIKTSGDINNKVPINTIGGKGLFIKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E ALL + D+AVHS+KD+P + GL + + +R P D FVS+ Y S+ +LP + V Sbjct: 63 IEEALLIGKVDLAVHSVKDIPAFYCDGLIIPCVLKRSSPYDVFVSSKYQSIKSLPINATV 122 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR+ QL RPDL + +RGN+ TR+ K D GE+D I+LA AGL R+ + I+ Sbjct: 123 GTSSIRRKVQLNYLRPDLQVIPVRGNIDTRILKSDIGEFDGIVLAEAGLIRINKCNVIKE 182 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L +I L AVGQGA+ ++CR DD + LN H++ + V AER+ + G C P Sbjct: 183 VLDSKIMLSAVGQGAICVQCRADDYNIINKIKVLNCHKSYVCVIAERSFLKTINGSCDTP 242 Query: 246 IGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 + + A+ +D + I++ ++ + +++ + +AE+ GI + ++L+N Sbjct: 243 LAALAQYVDSDTIYMSCMLS--NEKEMVFSDCYFKECNAEESGIDMGKKLIN 292 >UniRef50_B6FXV9 Putative uncharacterized protein n=1 Tax=Clostridium hiranonis DSM 13275 RepID=B6FXV9_9CLOT Length = 299 Score = 212 bits (540), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 116/298 (38%), Positives = 178/298 (59%), Gaps = 3/298 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +R+ TR S LAL Q ++ D+L P + E+ + T+GD IL L K+G KGLFVKE Sbjct: 3 IRVGTRGSNLALIQTNWAIDRLKEKFPEVEFEVKIIKTKGDKILHLSLDKIGDKGLFVKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV-SNNYDSLDALPAGSI 124 +E LLE D+AVHSMKD+P E +GL + +REDPRD + +S D LP G+ Sbjct: 63 IESQLLEGEIDLAVHSMKDMPAEVVEGLKFAAVPKREDPRDVIILREGLNSFDELPIGAT 122 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GT S RR+ QL +RPDL I +RGN+ TR+SK+++ D I+LA +G+ R LE +I Sbjct: 123 IGTGSKRRKYQLLRKRPDLNIVPIRGNIETRISKIESENLDGIVLAASGVIRADLEEKIT 182 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 LP ++ +PA QGA+ +E R +D +++ A+ + ++ AER+ ++G C + Sbjct: 183 EFLPVDLMIPAPAQGALALEIRENDEELEKMIDAIKDEISQIQTDAERSYLAGIDGSCHI 242 Query: 245 PIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 P+G+Y E +DGE + L + G DG +I G + +++G +LA+ +L E Sbjct: 243 PMGAYCE-VDGEKLTLTGIFGDEDGEKITVASLEGDRDNPKELGSNLAKLVLKKHREE 299 >UniRef50_C3PNS9 Porphobilinogen deaminase n=15 Tax=Rickettsia RepID=HEM3_RICAE Length = 351 Score = 212 bits (540), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 108/256 (42%), Positives = 159/256 (62%), Gaps = 3/256 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + N +RI TR+SPLAL + V ++ P + E+VP++T GD+I + PL +GGK L Sbjct: 1 MTNSIRIGTRKSPLALIHTNLVIQQIKQFFPDINCEIVPIITSGDLIQNKPLYDIGGKAL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F+KE+E ALL+ + D+AVHS+KDVP P+ L + + EREDPRD FV Y S++ LP Sbjct: 61 FLKEIEQALLDKKIDLAVHSLKDVPGRIPEPLVIAAVLEREDPRDVFVCLKYKSIEELPQ 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 +++G+S++RR+ + + RPDL + RGNV +R+ KL GE DA ILA GLKRL + + Sbjct: 121 NAVIGSSAVRRKAFIQKIRPDLKVTVFRGNVDSRIKKLMTGEVDATILAYTGLKRLEVFN 180 Query: 182 RIRAALPPEIS--LPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 L E S LP +GQG + +E R DD+ E+ +NH T + ERA L+ Sbjct: 181 PEYCHL-IEYSQMLPCIGQGVIAVEIRKDDNAMLEICNQINHLPTFELIKPERAFLEYLD 239 Query: 240 GGCQVPIGSYAELIDG 255 C+ PI +Y++ +D Sbjct: 240 ANCRTPIAAYSQYLDA 255 >UniRef50_Q180R9 Porphobilinogen deaminase n=11 Tax=Bacteria RepID=HEM3_CLOD6 Length = 301 Score = 212 bits (539), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 111/289 (38%), Positives = 172/289 (59%), Gaps = 1/289 (0%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67 + TR S LAL Q +V ++L +P + E+ + T+GD+I + L K+G KGLFVKE+E Sbjct: 5 VGTRGSNLALIQTEWVINELKKKYPEISFEIKIIKTKGDLIQNVSLDKIGDKGLFVKEIE 64 Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV-SNNYDSLDALPAGSIVG 126 LL+ + DIAVHSMKD+P GL +REDPRD + Y +LD LP G+++G Sbjct: 65 QQLLDGKIDIAVHSMKDMPSYLANGLKFAHTPKREDPRDVLILREGYKNLDDLPHGAVIG 124 Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAA 186 T S RR+ QL ++RPDL I +RGNV TR+ K+ + I+LA +G+ R L+ +I + Sbjct: 125 TGSKRRKFQLLKQRPDLNIVQVRGNVETRIRKIKDENMHGIVLAASGIIRANLQDKISSY 184 Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246 LP ++ +PA QGA+ IE R +DS ++ +L T +++ AER + G C +P+ Sbjct: 185 LPVDVVIPAPAQGALAIEIRSNDSAIEGIVNSLKDENTEIQILAERGFLDGVNGSCHIPM 244 Query: 247 GSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295 +Y E+I +I L L G +G +++ G ++G+ LA+ +L Sbjct: 245 AAYCEIIQDKIHLTGLYGDSEGKKVVIKSIDGDISSPRELGLKLAKLVL 293 >UniRef50_A3VPD5 Porphobilinogen deaminase n=1 Tax=Parvularcula bermudensis HTCC2503 RepID=A3VPD5_9PROT Length = 324 Score = 211 bits (538), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 135/280 (48%), Positives = 180/280 (64%), Gaps = 12/280 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELV---------PMVTRGDVILDTPLAKV 56 LRIA+R+SPLA+ QA +V+D+L + L ++ V VT GD +L+ LA + Sbjct: 6 LRIASRRSPLAVAQALWVRDRLAEA---LGIDEVDRDAAFPHETFVTTGDRMLNPTLADI 62 Query: 57 GGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSL 116 GGKGLF KE+E+ALL+ +ADIAVHSMKD+P + P GL L + REDPRDAFV+ + L Sbjct: 63 GGKGLFTKEIEIALLDGQADIAVHSMKDMPAQMPPGLVLAAVPVREDPRDAFVTLDGRPL 122 Query: 117 DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKR 176 D +PAG+ +GTSS RR+ QLA RPDL + +RGNVGTRL KL GE + LA AGL+R Sbjct: 123 DQMPAGARIGTSSTRRRAQLARLRPDLALVPMRGNVGTRLQKLAAGEAEGTFLAEAGLRR 182 Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236 LG+ R AL P LPA+GQGA+ ++ R D T A +N+ TAL AERA+ + Sbjct: 183 LGMTDVKREALSPARMLPALGQGALCVQARSGDHETLSACAHINNRPTALAAAAERALIS 242 Query: 237 RLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER 276 L+G C+ PIG A + L + PDG +++RGER Sbjct: 243 GLDGSCKTPIGGLARQTGDSLILEGQILTPDGRRVLRGER 282 >UniRef50_Q5HBG1 Porphobilinogen deaminase n=2 Tax=Ehrlichia ruminantium RepID=Q5HBG1_EHRRW Length = 299 Score = 211 bits (538), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 111/292 (38%), Positives = 177/292 (60%), Gaps = 3/292 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 + + TR S LA+ QA VK L P + V++V +VT GD+ L+++GGKGLF+KE Sbjct: 6 VYVGTRGSILAIAQAMEVKKLLYNYFPDINVQIVHIVTSGDINDKISLSEIGGKGLFLKE 65 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE ALL D+AVHSMKDVP + L + I +R P D F+S+ Y SL +LP +++ Sbjct: 66 LEEALLTGTIDLAVHSMKDVPAFYCDSLVIPCILKRSSPYDVFISSKYQSLRSLPDNAVI 125 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR+ QL + + +RGNV TR+ KL+ G+YD IILA AGL R+ I+ Sbjct: 126 GTSSIRRKVQLMRLLSSVQVVPIRGNVDTRILKLEAGQYDGIILAKAGLMRINKTHVIKE 185 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L P++ L AVGQGA+GI+CR +D + +++ LN ++ + V AER+ + G C P Sbjct: 186 VLDPQVMLSAVGQGAIGIQCRANDYKMIDMIKILNCKKSYISVAAERSFMKTVNGSCDTP 245 Query: 246 IGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 + + A+ ++ + +++ ++ + + + + DAE GI++ +L++ Sbjct: 246 LAALAKYVNSDTLYMSCMLSNEE--KTVFSDCYFNECDAEISGINMGNDLMD 295 >UniRef50_B3U3W9 Hydroxymethylbilane synthetase n=1 Tax=Oxyrrhis marina RepID=B3U3W9_OXYMA Length = 395 Score = 209 bits (533), Expect = 7e-53, Method: Compositional matrix adjust. Identities = 133/305 (43%), Positives = 173/305 (56%), Gaps = 7/305 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMAS-HPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR SPLAL QA V+ + G +++ + T GD ILD LA VGGKGLF K Sbjct: 76 LRIGTRGSPLALAQARDVESRAREQLQQGGEIDICVISTEGDRILDRALADVGGKGLFTK 135 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 EL+ ALL D VHSMKDVP G +V RED RD F+S Y +L LP G++ Sbjct: 136 ELDRALLSGEVDCCVHSMKDVPTTVAPGTEIVAYLPREDTRDVFLSAKYATLADLPDGAV 195 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGT+SLRRQ Q+ ++ ++++ + RGNV TRL KL G D LA AGLKRLG+ + Sbjct: 196 VGTASLRRQAQILAQK-NVVVTNFRGNVQTRLRKLAAGTVDCTFLAYAGLKRLGMLAEAT 254 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L LPA+ QGAVGI+ R +D+ R L+ L+H T L V ERA L+G C+ Sbjct: 255 QVLEWSDMLPAIAQGAVGIQIRSNDAALRGTLSQLDHEPTRLAVETERAFLRALDGSCRT 314 Query: 245 PIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRG--APQDAEQMGISLAEELLNNGARE 301 PI A + D + R V + DG Q R ER G P D ++G +L ++L E Sbjct: 315 PIAGQAWIGPDSRLAFRGQVLSADGKQ--RFERVGDCLPCDGPELGKTLGDDLRREAGEE 372 Query: 302 ILAEV 306 AE+ Sbjct: 373 FFAEL 377 >UniRef50_A8MDU3 Probable porphobilinogen deaminase n=2 Tax=Thermoproteaceae RepID=HEM3_CALMQ Length = 305 Score = 209 bits (533), Expect = 7e-53, Method: Compositional matrix adjust. Identities = 124/302 (41%), Positives = 181/302 (59%), Gaps = 2/302 (0%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 ++RIATR S L+L Q V D+++ + + +L+ + T GDV L PL ++G KG+F + Sbjct: 2 IIRIATRGSALSLKQTKIVMDRILEFNKDVEFKLIIVKTTGDVDLSKPLYEIGVKGIFER 61 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E+ A+L AD+AVHS+KD+P + L LV R++PRDA VS ++D LP SI Sbjct: 62 EVNQAVLRGEADVAVHSLKDMPAQISNDLTLVMTPPRDNPRDALVSLRQYTVDTLPLNSI 121 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGTSSLRR+ L R D+ ++ +RGNV TR+ KL+NGEYDA+I+A AGL+RL + + + Sbjct: 122 VGTSSLRRRGFLLSLRRDVTVKPIRGNVDTRIRKLNNGEYDALIMAAAGLERLSINANV- 180 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 + + PE+ PA GQG +G+ R D ++L + ET AERA +R+ GC V Sbjct: 181 SEISPELMPPAPGQGIIGVVARRDRDDLIKVLRRSSDEETFKEAAAERAFLSRIGAGCHV 240 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 P+G A L DG V PDG + R ++ E+ G AE+LL N AR ++A Sbjct: 241 PLGGLALLDDGYFDFTYGVVDPDGVEKFINSTRIDARNPEEAGRVAAEDLLRN-ARGLVA 299 Query: 305 EV 306 + Sbjct: 300 RL 301 >UniRef50_C4Z552 Porphobilinogen deaminase n=8 Tax=Bacteria RepID=HEM3_EUBE2 Length = 295 Score = 209 bits (531), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 121/284 (42%), Positives = 164/284 (57%), Gaps = 5/284 (1%) Query: 7 RIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66 RI TR S LAL Q+ YVK ++ ++P ELV + T GD + D PLA +G KG FVKE+ Sbjct: 4 RIGTRGSKLALVQSEYVKRRMEEAYPEDTFELVIIKTTGDKVTDKPLAAIGTKGFFVKEI 63 Query: 67 EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126 E ALL D+AVHSMKD+P E GL +RED RD + S LP+G+++G Sbjct: 64 EEALLSGSIDMAVHSMKDMPAECAAGLTFAKAWKREDCRDVLILKTAGSFSELPSGAVIG 123 Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY--DAIILAVAGLKRLGLESRIR 184 T SLRR CQLA RPD+ ++RGNV TR++KL + Y D I+LA AGL RLG S I Sbjct: 124 TGSLRRACQLAMLRPDIQFTAIRGNVDTRINKLMDDSYGLDGIVLAAAGLNRLGRSSEIT 183 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L PE+ +PA QG + IE ++ + + AL+ + AER GGC Sbjct: 184 EYLDPEVVIPAPAQGVLAIETAEVNTELLDKINALSDDNSDREAVAERTFLRLTGGGCHA 243 Query: 245 PIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMG 287 P+G++ D G++ + L G D S+I+R E G D+E +G Sbjct: 244 PVGAHCVTKDNGDLRMVVLFGNDDCSRILRIEVTGT--DSEAVG 285 >UniRef50_A5CDH4 Porphobilinogen deaminase n=2 Tax=Orientia tsutsugamushi RepID=HEM3_ORITB Length = 298 Score = 208 bits (529), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 124/292 (42%), Positives = 162/292 (55%), Gaps = 3/292 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 ++R+ +R S LAL QA V K+ GL ++P+ T GD+I + L +GGKGLF+K Sbjct: 2 IIRVGSRASRLALIQAQAVVQKI-NDLLGLNAIIIPIKTTGDLIQNKNLYDIGGKGLFLK 60 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E+E ALL N DIAVHS+KDVP P GL L + ER D D VS + + LP G+I Sbjct: 61 EIEYALLNNTIDIAVHSLKDVPAYLPDGLQLAAVLERGDVGDMLVSKIANKITDLPLGAI 120 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE-SRI 183 VGTSS+RR+ QL RPDL I RGNV TR +K+ N E DA +LA AGL+RL + SR Sbjct: 121 VGTSSVRRRIQLLMLRPDLNIVLFRGNVDTRWNKIINNEVDATVLAAAGLQRLNYDTSRF 180 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 +P LPA+GQGA+ IE R DD L A +NH T + ER L C Sbjct: 181 CNIIPQSEMLPAIGQGAIAIEARKDDKLIMPLCAKINHQLTWQLIQVERGYLKTLNADCN 240 Query: 244 VPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 VPIG A I + + ++G + E RG Q +G+ A+ Sbjct: 241 VPIGGIASYIGNNSFEAKFMLGDYNMRYFFYSEVRGKLQHGYDIGVEAAKNF 292 >UniRef50_Q1EPC8 Porphobilinogen deaminase, chloroplast (Hydroxymethylbilane synthase) (Pre-uroporphyrinogen synthase), putative n=1 Tax=Musa acuminata RepID=Q1EPC8_MUSAC Length = 328 Score = 207 bits (526), Expect = 5e-52, Method: Compositional matrix adjust. Identities = 129/291 (44%), Positives = 167/291 (57%), Gaps = 34/291 (11%) Query: 11 RQSPLALWQAHYVKDKLMASHPGLV----VELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66 R S LAL QA +DKL A+H L VE++ + T GD+ILD PLA +GGKGLF KE+ Sbjct: 54 RDSDLALAQARETRDKLKAAHSELAEEGAVEIIIIKTTGDMILDKPLADIGGKGLFTKEI 113 Query: 67 EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126 + ALL+ R DIAVHSMKDVP P+G + C LPA Sbjct: 114 DDALLQGRIDIAVHSMKDVPTYLPEGT--ILPCN------------------LPA----- 148 Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAA 186 SLRRQ Q+ R P L + +LRGNV TRL+KL NG+ A +LA+AGLKRL + + + Sbjct: 149 --SLRRQSQILCRYPSLKVVNLRGNVQTRLTKLKNGDVHATLLALAGLKRLNMVENVTSI 206 Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246 L E LPAV QGA+GI CR +D++ E L++LNH +T V ER T L+G C+ PI Sbjct: 207 LSMEEMLPAVAQGAIGIACRSNDNKMMEYLSSLNHEDTRSAVACEREFLTVLDGNCRTPI 266 Query: 247 GSYAEL-IDGEIWLRALVGAPDGSQIIRGERRG--APQDAEQMGISLAEEL 294 +YA DG R L+ +PDGS++ R G + D +MG EL Sbjct: 267 AAYAHRDKDGSCSFRGLLASPDGSKVYETTRIGPYSFDDMVEMGKDAGHEL 317 >UniRef50_C1CYD9 Porphobilinogen deaminase n=3 Tax=Deinococci RepID=HEM3_DEIDV Length = 311 Score = 207 bits (526), Expect = 5e-52, Method: Compositional matrix adjust. Identities = 126/304 (41%), Positives = 178/304 (58%), Gaps = 5/304 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDT--PLAKVGGKGLF 62 + + TR S LAL Q +V +L P + + T+GD ++ +A+ G KG + Sbjct: 3 TVTVGTRGSTLALAQTRWVVARLKEEWPDTDFRIQTISTKGDRNRESLEAMAQKGDKGFW 62 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALPA 121 VKE+E ALL+ R DIAVHS+KD+P E P+GL + +I +R D RD + L LP Sbjct: 63 VKEIEDALLQKRIDIAVHSLKDLPTEQPEGLEVASIPKRVDARDVLIGKEGMKRLADLPQ 122 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ VGTSS+RR+ L RPDL + LRGN+ TRL+ L EYDAIILA AGL R + Sbjct: 123 GARVGTSSVRRKAFLRAYRPDLQVIDLRGNIDTRLAALAGDEYDAIILAAAGLIRTEMRH 182 Query: 182 RIRAALPPEISLPAVGQGAVGIECRL--DDSRTRELLAALNHHETALRVTAERAMNTRLE 239 RI + P+I LPA GQGA+ +E R ++ T E+ A++ H T R+TAER L Sbjct: 183 RIDEFVEPDILLPAPGQGALALETRSGPENDLTIEVAYAIHDHGTDDRITAEREFLAGLG 242 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GC P+G++A + G + L VGA DGS++IR G P + +G LA ++L GA Sbjct: 243 AGCMAPVGAHASIKGGVLTLEGWVGALDGSKVIRATSIGDPAECADIGAELAGDMLGQGA 302 Query: 300 REIL 303 + ++ Sbjct: 303 QALI 306 >UniRef50_B8GXG1 Porphobilinogen deaminase n=8 Tax=Caulobacteraceae RepID=HEM3_CAUCN Length = 322 Score = 205 bits (522), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 132/285 (46%), Positives = 169/285 (59%), Gaps = 21/285 (7%) Query: 6 LRIATRQSPLALWQ--------AHYV-------KDKLMASHPGLVVELVPMVTRGDVILD 50 +RI R S L+L Q AH + KD++ A+ P L+P+VT GD I D Sbjct: 7 IRIGARGSKLSLAQSGLMQARIAHALGVPAGASKDEIEAAAP-----LIPIVTSGDRIQD 61 Query: 51 TPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS 110 L ++GGKGLF KE+E ALL+ R D AVHS+KD+P E P GL L EREDPRDAF+S Sbjct: 62 RRLMEIGGKGLFTKEIEEALLDGRIDCAVHSLKDMPAELPPGLVLAATPEREDPRDAFIS 121 Query: 111 NNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILA 170 + + L+ LP G+ +GT+SLRRQ Q RPDL I LRGNV TRL+KL+ GE DAI+LA Sbjct: 122 HVCERLEDLPKGARLGTASLRRQAQALHVRPDLEIVMLRGNVDTRLAKLERGEADAILLA 181 Query: 171 VAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTA 230 +GL RLGL R+ L P+ PA GQGA+ IE R +D L A+ +T + V A Sbjct: 182 QSGLNRLGLGHLTRSWLDPDACPPAPGQGALVIETRAEDIGA-PWLEAVRCRQTTIAVAA 240 Query: 231 ERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE 275 ER LEG C+ IG+ A L + + PDG+Q R E Sbjct: 241 ERGALLALEGSCRTAIGARAILDGARLSMIVEALTPDGAQRFRRE 285 >UniRef50_Q8TXC8 Probable porphobilinogen deaminase n=1 Tax=Methanopyrus kandleri RepID=HEM3_METKA Length = 298 Score = 205 bits (522), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 126/302 (41%), Positives = 181/302 (59%), Gaps = 9/302 (2%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLV-VELVPMVTRGDVILDTPLAKVGGKG 60 + +R+ATR S LA+ Q V + L P V VE+V +RGDV+ D PL K+G KG Sbjct: 1 MSETIRVATRSSRLAIIQTREVIELLERESPRDVEVEIVKTKSRGDVVRDRPLHKLGEKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVP--VEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118 +FVKE++ +LE +ADIAVHS KDVP V++P + + + R DPR+ VS + L Sbjct: 61 VFVKEVDRLVLEGKADIAVHSAKDVPSVVDYP--VDVAAVPPRRDPRECLVSR-HGGLKE 117 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 LP G+ VGTSS RR+ Q+ RPDL + +RGNV TR+SK+ EYDA +LA GL RLG Sbjct: 118 LPRGATVGTSSPRRRAQILLERPDLKVEPMRGNVDTRVSKVRRREYDAAVLAKVGLDRLG 177 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 + S + PE +P GQGA+ I CR DD R + LL ++ ++ + V E+A+ L Sbjct: 178 MTSEVSEVYDPEEFVPPAGQGALMITCRKDDDRVKRLLEVVDDEKSRVEVETEKAVVREL 237 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVG--APDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 GC P+G + DG+ +R ++G DGS + RG+P+D + +S A E+L+ Sbjct: 238 GVGCSEPVGVHVRARDGD-HVRLVLGLFEEDGSCGHVLKMRGSPEDVVREAVSQAREVLS 296 Query: 297 NG 298 +G Sbjct: 297 DG 298 >UniRef50_B2IAW6 Porphobilinogen deaminase n=4 Tax=Alphaproteobacteria RepID=B2IAW6_BEII9 Length = 337 Score = 205 bits (522), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 141/307 (45%), Positives = 180/307 (58%), Gaps = 7/307 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMV---TRGDVILDTPLAKVGGKGLF 62 LR+ TR SPLAL QAH + D+L +H G E V + T GD+I D PL+ GGKGLF Sbjct: 19 LRLGTRGSPLALAQAHELADRLARAH-GFAKEAVAITIIRTSGDMIQDRPLSLAGGKGLF 77 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 KEL+ AL+E D+AVHS KD+P P+ L + RED RD ++S LP G Sbjct: 78 TKELDQALIEGMVDLAVHSAKDLPTILPEDLIIAGYLPREDVRDVWISPKAGHPRDLPPG 137 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 S+VGT+SLRR L RPDL +R LRGNV TRL+KL GE DA +LA+AGL+RLGL + Sbjct: 138 SVVGTASLRRGALLKRLRPDLEVRLLRGNVETRLAKLAAGEVDATLLALAGLRRLGLADK 197 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 L E LPA GQGA+GI R DD+ T LLA + T + + AER T L+G C Sbjct: 198 ATQVLAIEDFLPAAGQGAIGITTRRDDAATLALLAPILDPATHVALAAERGFLTVLDGSC 257 Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 + PIG++A + ++ LR +V PDGS+ G E + A EL AR I Sbjct: 258 KTPIGAHATVEHDQVTLRGIVLRPDGSEWFEACESGP---LESGSLEAARELGETAARAI 314 Query: 303 LAEVYNG 309 LA + G Sbjct: 315 LARLPEG 321 >UniRef50_Q11XT5 Porphobilinogen deaminase n=8 Tax=Bacteria RepID=HEM3_CYTH3 Length = 312 Score = 204 bits (520), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 129/311 (41%), Positives = 177/311 (56%), Gaps = 6/311 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 ++ +RI TR S LALWQA +V L GL ++V + T GD ILD L+K+G KGL Sbjct: 1 MNKTVRIGTRGSKLALWQAEHVAACLQT--KGLEPQIVIIDTTGDKILDQSLSKIGSKGL 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALP 120 F +ELE L DIAVHS KD+ G+ ++ I ERE D VS+ D+L P Sbjct: 59 FTEELEEQLHAGTIDIAVHSAKDLQTHLKGGMYILAITERELVNDVLVSHKPIDTLKNNP 118 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 I+GTSS RR+ L + P + +RGN+ TR+ K++ G DA++LA AG+ R+G + Sbjct: 119 -DLIIGTSSTRRRALLRKFYPQAKMVDMRGNLQTRIRKMEEGACDAMLLAYAGMHRMGYD 177 Query: 181 SRIRAALPPEISLPAVGQGAVGIEC--RLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 S I+ L E +PA GQG + IE LD + + A LN T V+AERA L Sbjct: 178 SLIKEKLSLEEFIPAAGQGTLAIEAASTLDKEKAAVIRAVLNDAATETAVSAERAFLRTL 237 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 EGGC +P+ + A D + L + + DG++ +R E R DAEQ G+ LA LL +G Sbjct: 238 EGGCSIPVFALAVERDTDYLLTGGIVSLDGTKYLRKEIRFTAADAEQRGVELATVLLKDG 297 Query: 299 AREILAEVYNG 309 A EILAE+ G Sbjct: 298 ADEILAEIKKG 308 >UniRef50_A2BL26 Probable porphobilinogen deaminase n=2 Tax=Thermoprotei RepID=HEM3_HYPBU Length = 303 Score = 204 bits (518), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 127/298 (42%), Positives = 168/298 (56%), Gaps = 3/298 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LR+ATR S L++ Q + + P L ELV + TRGD+ D P +GGKGLF KE Sbjct: 3 LRVATRGSKLSIAQTMIALEAIKRVEPSLEYELVIVKTRGDIHQDKPFTAIGGKGLFEKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV--SNNYDSLDALPAGS 123 + +A+LE RADIAVHS+KDVP GL L R+ P D V ++ LP+G+ Sbjct: 63 VNLAVLEGRADIAVHSLKDVPSAISPGLVLAMTPPRDPPYDVLVVRGGKEKTIWDLPSGA 122 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 IVGTSS RR L R DL+ + LRGNV TRL KL+ G+YDAI+LA AGLKRLG++ Sbjct: 123 IVGTSSARRVAMLKHVRRDLVFKVLRGNVDTRLRKLEQGQYDAIVLAEAGLKRLGVDIEY 182 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 +PP+I PA GQG +G+ S +L + + AERA GGC Sbjct: 183 -WRIPPDILPPAPGQGIIGVYTLSSRSDILPILEKASDQKAMAEARAERAFLAYAGGGCH 241 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 P+G+YAEL ++ A + +PDGS+ + G P Q+G+ A EL ARE Sbjct: 242 TPLGAYAELRGNTLYFHAALASPDGSRRVEVRVEGDPDKPTQVGLEAAFELRRLAARE 299 >UniRef50_B3T8H9 Putative Porphobilinogen deaminase, dipyromethane cofactor binding domain protein n=1 Tax=uncultured marine microorganism HF4000_APKG5H11 RepID=B3T8H9_9ZZZZ Length = 322 Score = 204 bits (518), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 121/299 (40%), Positives = 170/299 (56%), Gaps = 1/299 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +++ +R S LAL Q H V ++L A+ P L E+ + TRGDV + LA +G G+FVKE Sbjct: 18 IKVGSRGSTLALIQDHVVINRLKANSPALEFEVDTVRTRGDVDQTSRLAGMG-LGIFVKE 76 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE LL+ + DIAVHS+KD+P + GL L + REDPRD V+ LD LP G+ + Sbjct: 77 LEQELLDGKLDIAVHSLKDMPTQLADGLVLGAVLSREDPRDVLVNRYGCPLDGLPKGAKI 136 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS RR QL + P + + S+RGNV TRL K E D ILA AG+ RLGL+ +I Sbjct: 137 GTSSPRRAAQLKQYAPQVEVVSIRGNVETRLRKAQGEEADGAILAAAGMIRLGLQDQIAE 196 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L +P GQG + +E R DD R ELL+A++ +T TAER RL GGC +P Sbjct: 197 YLSATQFVPPPGQGILAVEARADDFRMLELLSAIDDADTRYEATAERGFLARLGGGCSIP 256 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 +G+YA I + + DG + + +G +D Q+ L+ G +++A Sbjct: 257 VGAYARCNGDNIVMTIYMSTADGEKKFSAKIQGLKRDPLQLANDAYLALVERGGADLVA 315 >UniRef50_B0K2L4 Porphobilinogen deaminase n=7 Tax=Bacteria RepID=B0K2L4_THEPX Length = 299 Score = 204 bits (518), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 110/296 (37%), Positives = 172/296 (58%), Gaps = 3/296 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + V+++ TR S LAL Q V +++ E+V + T+GD ++D P++++GGKG+ Sbjct: 1 MKKVIKVGTRSSELALKQTAMVINEIKKFRQDFEFEIVKITTQGDALIDKPVSEIGGKGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKE+E ALL+ D+AVHSMKD+P E P+GL L+ + +REDP+D FVS + L Sbjct: 61 FVKEIESALLKGEIDMAVHSMKDMPYEIPKGLKLMAVLKREDPKDVFVSGDGTQFMDLKE 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ +GTSSLRRQ QL +PD+ I +RGNV TRL K++ D I+L+ AGL RLGLE+ Sbjct: 121 GAKIGTSSLRRQVQLKALKPDIQIVPIRGNVRTRLKKMEELNLDGIVLSAAGLHRLGLEN 180 Query: 182 RIRAALPPEISLPAVGQGAVGIE-CRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 I PP++ +PA QG + +E D+ +E + +T + ER + Sbjct: 181 IITEYFPPDVVVPAPCQGILAVEIAESFDNIFQEFYPYIVDRKTFFEASVERELLKAFGV 240 Query: 241 GCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 C+ P G+YA+ + E + V +++++ E G ++ ++M L EE Sbjct: 241 NCRQPFGAYAQYRKEEDEEKINIKVAYQKENKLLKSEVTGLIEETDKMIEKLIEEF 296 >UniRef50_A0QLI0 Porphobilinogen deaminase n=69 Tax=Actinomycetales RepID=HEM3_MYCA1 Length = 315 Score = 204 bits (518), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 136/310 (43%), Positives = 178/310 (57%), Gaps = 15/310 (4%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMA-SHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 ++RI TR S LA QA V+D L+A HP ELV + T GD P+ +G G+F Sbjct: 1 MIRIGTRGSLLATTQAGGVRDALIARGHP---AELVTITTAGDRS-SGPIESLG-VGVFT 55 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 L A+ E R D AVHS KD+P + I R DPRDA V+ + L LP GS Sbjct: 56 TALREAIEEGRVDAAVHSHKDLPTADDPRFAVAAIPARNDPRDAVVARDGLVLGELPPGS 115 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +VGTSS RR QL L IR LRGN+ TRL+++ +G+ DAI++A AGL RLG + Sbjct: 116 LVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLGDV 175 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 L P LPA QGA+ +ECR DSR +LA L+ +T VTAERA+ LE GC Sbjct: 176 TETLEPVQMLPAPAQGALAVECRAGDSRLAAVLAELDDADTRASVTAERALLAELEAGCS 235 Query: 244 VPIGSYAELI-----DGEIW----LRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 P+G+ AE++ DG I+ LR V A DGS +IR G P A ++G+S+A EL Sbjct: 236 APVGAIAEVVESIDEDGRIFEELSLRGCVAALDGSDVIRASGIGTPGRARELGLSVAAEL 295 Query: 295 LNNGAREILA 304 GARE+++ Sbjct: 296 FELGARELMS 305 >UniRef50_D1CBT4 Porphobilinogen deaminase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CBT4_THET1 Length = 300 Score = 202 bits (515), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 112/297 (37%), Positives = 171/297 (57%), Gaps = 2/297 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 V+++ TR S LALWQ +V ++L + +PG E V + D D P++ +G G+F Sbjct: 2 KVIKVGTRGSKLALWQTQWVINRLRSLYPGFQFEPVVIKVTSDRSPDAPISAIGQVGVFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 K++E ALL +AVHS+KD+P G + EREDPRD + + L S Sbjct: 62 KDIEQALLAGDIHLAVHSLKDLPTLSTPGTVIAAFTEREDPRDCILWPKGQPMPDL-NNS 120 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGTSS+RR + P+ + +LRGNV TR+ K+ G YD +++A A +KR+ L Sbjct: 121 RVGTSSVRRSALVRSYWPNANVVNLRGNVDTRVRKMLEGNYDVVLMAYAAVKRMDLPVEF 180 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + LP + +P+ GQG + ++ R DD + +L A+N + + AER++ L GGC Sbjct: 181 KP-LPLDSWVPSAGQGIIAVQAREDDQQIIGMLNAINFFPSKVAYLAERSLMRALGGGCS 239 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 +P+G+YAEL DGE+ L +V APDGSQ++ R P A+ +G +A E+L+ G R Sbjct: 240 MPVGAYAELHDGELSLIGMVAAPDGSQVVITRRVDTPDQADHLGERVAREMLDLGIR 296 >UniRef50_A6GVP0 Hydroxymethylbilane synthase n=18 Tax=Bacteroidetes RepID=A6GVP0_FLAPJ Length = 308 Score = 202 bits (515), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 112/308 (36%), Positives = 174/308 (56%), Gaps = 8/308 (2%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M ++I TR S LALWQAH+V+ M + G +++ + ++GD+ILD PL ++G G Sbjct: 1 MAKKTIKIGTRDSELALWQAHHVEK--MLNDLGHKTKIIAVKSQGDIILDKPLYELGITG 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 +F K L++A++ DIAVHSMKDVP PQG+ + ER + +D V NN +LD L Sbjct: 59 IFTKTLDIAMVNGDIDIAVHSMKDVPTALPQGIVQAAVLERANEKDILVYNN--NLDFLN 116 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 + + T SLRRQ Q + P+ + LRGNV TR+ KL + ++ + A AGL+R+ ++ Sbjct: 117 TQATIATGSLRRQAQWLHKYPNHKVVDLRGNVNTRMQKLQDNNWNGAVFAAAGLERINIK 176 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 L + +PA QGA+ + +D+ + LA LNH ET + ER LEG Sbjct: 177 PENYINL--DWMIPAPAQGAMMVVAMGNDTYCLDALAELNHIETEITTYIERQFLRTLEG 234 Query: 241 GCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GC PIG+YA D I + ++ + DGSQ I ++ Q+ +Q+G +E+ NG Sbjct: 235 GCTAPIGAYARFNEKDETIHFQGVLFSLDGSQKIEIKKIVEIQEWKQLGYHAGQEIFENG 294 Query: 299 AREILAEV 306 +++ + Sbjct: 295 GVQLMKTI 302 >UniRef50_A0LRF1 Porphobilinogen deaminase n=1 Tax=Acidothermus cellulolyticus 11B RepID=HEM3_ACIC1 Length = 331 Score = 201 bits (512), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 129/305 (42%), Positives = 167/305 (54%), Gaps = 8/305 (2%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +VLR+ TR+S LA Q + L A+ G VE+V + + GD D PL + G G+FV Sbjct: 8 SVLRLGTRRSTLARAQTEEIAGALRAA--GCRVEIVGIQSTGDRHADVPLHEFAGSGVFV 65 Query: 64 KELEVALLENRADIAVHSMKDVPV-EFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 EL ALL D+ VHSMKD+P E P+ L + I R DPRDA V+ L LP G Sbjct: 66 AELRAALLRGEVDVVVHSMKDLPTAEIPE-LAIAAIPRRADPRDALVTGAGCRLAELPTG 124 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 +IVGT S RR QL RPDL IR +RGN+ TRL KL G Y A+I+A AGL RL Sbjct: 125 AIVGTGSPRRAAQLRLLRPDLEIRPIRGNLDTRLGKLHAGGYAALIVAAAGLARLHRSEE 184 Query: 183 IRAALPPEISLPAVGQGAVGIECR----LDDSRTRELLAALNHHETALRVTAERAMNTRL 238 P + LPA GQGA+ +ECR D R +LA L+ T VTAERA+ + Sbjct: 185 AAEFFDPTVMLPAPGQGALAVECRRADIADGGRLAGILAGLDDPATRAAVTAERALLAAV 244 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GC P+G+ + + L A+V P G+ R G P DA +G LA +L+ G Sbjct: 245 GAGCSAPVGALGVVTADTLQLDAVVVDPSGTTAFRRSLTGTPDDASDLGRRLAADLIRAG 304 Query: 299 AREIL 303 A ++L Sbjct: 305 ADQLL 309 >UniRef50_A9A1A1 Probable porphobilinogen deaminase n=3 Tax=Thaumarchaeota RepID=HEM3_NITMS Length = 311 Score = 201 bits (512), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 107/295 (36%), Positives = 171/295 (57%), Gaps = 2/295 (0%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67 + R S L++ Q + V +L +HP E+ + T+GD PL + KG+F KE++ Sbjct: 5 VGARGSQLSVAQTNLVIAELKKAHPDTEYEIKTITTKGDTD-SRPLFTIDQKGIFEKEID 63 Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127 A+ + D AVHS+KDVP E L L I +RE D F+S + +LD++ GS++GT Sbjct: 64 RAVAQKEVDFAVHSLKDVPSELDDNLVLACIPKRETVNDVFISPDGSTLDSIKPGSVIGT 123 Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAAL 187 SSLRR Q++ +RPD+ ++ +RGN+ TR+ K YDAI+LA AG+ RLG++ + Sbjct: 124 SSLRRAVQVSRKRPDVTVKPIRGNIETRIKKASGENYDAIVLAKAGISRLGVDVKYTELS 183 Query: 188 PPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIG 247 + S P+ GQGA+ I R DDS+T E+L + ++ L + AERA++ ++ GC+ P+G Sbjct: 184 TDDFS-PSPGQGAIAIVARADDSKTIEMLKKIEDPDSRLEIEAERALSDFVDSGCRFPVG 242 Query: 248 SYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 +YA+ E+ L + DG Q + + G + + +G S EEL G ++ Sbjct: 243 AYAKSNGSEMTLTVTAFSVDGKQFLHVSKTGDKNNPKSLGQSAGEELREKGVNDL 297 >UniRef50_C6WZF5 Porphobilinogen deaminase n=1 Tax=Flavobacteriaceae bacterium 3519-10 RepID=C6WZF5_FLAB3 Length = 311 Score = 201 bits (511), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 111/302 (36%), Positives = 175/302 (57%), Gaps = 7/302 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 ++I TR SPLALWQA V L ++ ++ P++++GD L PL +G G+F K+ Sbjct: 12 IKIGTRNSPLALWQAREVARHLQNNNH--TTDITPIISKGDKNLSQPLYTLGITGIFTKD 69 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L++ALL N DIAVHS+KD+P + P+ + ++ + +R+ P+D V + L I Sbjct: 70 LDIALLNNEVDIAVHSLKDIPTQLPENVEIIAVLQRDYPQDVLVRKKDAATLELHQLKI- 128 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 TSSLRR+ + P +RGNV TRL+KL+ ++DA + ++A ++R+GL S Sbjct: 129 ATSSLRRRAFWLKEFPGTEFSDIRGNVQTRLTKLEENDFDATMFSLAAIERMGL-SVDYE 187 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 LP + +PA QG V + R +D +EL +NH ET + + ER+ + LEGGC P Sbjct: 188 HLP--LMIPAPAQGVVAVCARSNDPEIKELFKEINHRETRICIDIERSFLSTLEGGCTAP 245 Query: 246 IGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 IG++AE+ D GE+ + + DG I + A + + G LAE++L NG RE++ Sbjct: 246 IGAFAEINDLGEVRFTGRICSLDGQNCIETDEIFAWNEHDDFGKILAEKILQNGGRELMQ 305 Query: 305 EV 306 E+ Sbjct: 306 EI 307 >UniRef50_Q1V167 Hydroxymethylbilane synthase n=3 Tax=Candidatus Pelagibacter RepID=Q1V167_PELUB Length = 307 Score = 201 bits (510), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 111/290 (38%), Positives = 165/290 (56%), Gaps = 3/290 (1%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELV---PMVTRGDVILDTPLAKVGGKGLFVK 64 I +R S LAL A ++K++ +E V +VT+GD + D L++VGGKGLF K Sbjct: 8 IGSRGSKLALIYAEKAREKILKHSKDFGIEEVIIKEIVTKGDQVQDKRLSEVGGKGLFSK 67 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 +EV LLE + DIAVH++KD+P E +GL ER DPR+ +S + L L + SI Sbjct: 68 TIEVELLEKKIDIAVHALKDMPSEETRGLLTDCFLERNDPREILISKDNKHLKDLASNSI 127 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSS RR+ Q+ + R DL + +RGNV TR+ KL YDAIIL+ AG+ LGL I Sbjct: 128 IGTSSYRREFQIKKIRDDLNCKLIRGNVDTRIRKLKENLYDAIILSYAGIDSLGLNQNIS 187 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 +P GQG + ++CR +D ELL ++H T + AER + LEG C+ Sbjct: 188 QTFSTSEIIPCAGQGVIALQCRDNDESLIELLKQVDHQSTHSSIKAERNVLKVLEGDCET 247 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 +G++A + +I L + + DGS+ + + AE++GI + + L Sbjct: 248 AVGAFANIEGNKINLEVELFSLDGSKRFYLKSSESVDKAEELGIEMGKTL 297 >UniRef50_A2Q9P7 Catalytic activity: 4 porphobilinogen+H(2)O<=>hydroxymethylbilane+4 NH(3) n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2Q9P7_ASPNC Length = 346 Score = 201 bits (510), Expect = 4e-50, Method: Compositional matrix adjust. Identities = 123/324 (37%), Positives = 177/324 (54%), Gaps = 24/324 (7%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG-----KG 60 LR+ TR S LAL QA +V +L ++HPG+ +V RGD +P K G K Sbjct: 12 LRLGTRNSKLALVQAEHVSKELTSAHPGVQFPWQTVVVRGDADKSSPFLKFAGPSDAAKN 71 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV-----SNNYDS 115 ++ +E+E L D+ VH +KD+P P+ L I REDP DA V + Y Sbjct: 72 IWTEEMETKLCAGELDLLVHCLKDMPTRLPETCTLGAIVYREDPTDALVIKEGLRSQYTD 131 Query: 116 LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN--GEYDAIILAVAG 173 L LP GS+VGTSS RR+ L R P L + RGN+GTRL KLD+ G + AIILA AG Sbjct: 132 LSQLPPGSVVGTSSTRRKALLRYRYPHLKVEECRGNLGTRLKKLDDPEGPFSAIILATAG 191 Query: 174 LKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERA 233 + R+ LE RI LPP AVGQGA+GIE R +D++T+ ++ + T AER+ Sbjct: 192 MVRINLEDRITKRLPPSEFPYAVGQGALGIEIRKEDAQTKTMVRKIEDLVTRRICLAERS 251 Query: 234 MNTRLEGGCQVPIGSYAELID-------GEIWLRALVGAPDGSQIIRGERR----GAPQD 282 + L+GGC P+ + + ++ L + P G+ ++ ER G +D Sbjct: 252 LLRTLQGGCSSPVAVHCTVEQAPTASSPAQLRLDGTIIHPHGTTLL-SERTTAEVGTDED 310 Query: 283 AEQMGISLAEELLNNGAREILAEV 306 AE +G ++A++LL NG + +L E+ Sbjct: 311 AEALGATVAQQLLKNGGQALLEEI 334 >UniRef50_Q9F7M2 Predicted porphobilinogen deaminase n=2 Tax=Bacteria RepID=Q9F7M2_PRB01 Length = 303 Score = 200 bits (509), Expect = 4e-50, Method: Compositional matrix adjust. Identities = 110/298 (36%), Positives = 170/298 (57%), Gaps = 2/298 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RIATRQS LA++QA +V D+L+A + VELVPM + GD D PL ++GGKGLF+ Sbjct: 3 IRIATRQSELAMYQAKFVADELLAKINNIKVELVPMTSEGDQT-DKPLHEIGGKGLFIST 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE +L + ADIAVHS+KDVP + ++++ RE P D +S + S S + Sbjct: 62 LESSLEADEADIAVHSLKDVPAKLDPKFKIISVFSRESPEDLLLSKDGKSFSEFARNSTI 121 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTS RR+ Q+ RPD+ +RGN+ TR+ KL++G +D +++A A +KRLGL+ Sbjct: 122 GTSGPRRKAQINNLRPDIKTIPVRGNIATRIKKLNDGLFDGLVVAKAAIKRLGLKQN-SY 180 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 E LP+ QG + IEC D ELL + + + +AER+ +EG C P Sbjct: 181 EFSIEEMLPSASQGYIAIECLSDKKDIIELLENIGDPKELILASAERSFVAAMEGTCLSP 240 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 I E +G+I + + + +G++ I E+ + QD + A+E + GA+ ++ Sbjct: 241 IAILCEDKNGQIKISGKILSYEGNEKIYKEKISSFQDIAIDIMLFADEFILEGAKSLI 298 >UniRef50_C7N5L0 Porphobilinogen deaminase n=2 Tax=Slackia RepID=C7N5L0_SLAHD Length = 318 Score = 200 bits (508), Expect = 5e-50, Method: Compositional matrix adjust. Identities = 121/307 (39%), Positives = 169/307 (55%), Gaps = 5/307 (1%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67 I TR S LALWQ V +M + P + VE+ T GD+ L +PLA++G KGLF +ELE Sbjct: 7 IGTRGSKLALWQTETVGRAIMRAFPEIEVEIRVRNTTGDINLASPLAEIGDKGLFTRELE 66 Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALPAGSI 124 LL D+ VHS+KD+ E P+G + + R D RD V SL +P GS Sbjct: 67 TDLLLGEVDMCVHSLKDLETEQPEGCVVAGVLPRADARDVLVCGPRIQAASLAEVPEGSR 126 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GT S RR QL P+++ +RGNV TR++K + +Y+ ILA AG+KR+G E I Sbjct: 127 IGTGSRRRVAQLKANFPNMVPEGIRGNVDTRVAKAEGDDYEGAILAAAGMKRMGYEDHIA 186 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 A LP E +PA GQGA+ +E + R ++ ALN T AER + LEGGC Sbjct: 187 AYLPIEDMIPAPGQGAIAMEVLKKNERAYQIARALNDPVTKACTDAERFVLFSLEGGCSA 246 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGIS--LAEELLNNGAREI 302 PIG++ L DG+ A V + G++ R A+ M ++ + EL+ GAR I Sbjct: 247 PIGAHCRLEDGKYIFDACVLSLGGTKAARCHLEADADSADPMDMAWEVVSELIGEGARAI 306 Query: 303 LAEVYNG 309 L ++ NG Sbjct: 307 LRDIKNG 313 >UniRef50_Q0BX92 Porphobilinogen deaminase n=1 Tax=Hyphomonas neptunium ATCC 15444 RepID=HEM3_HYPNA Length = 321 Score = 199 bits (507), Expect = 8e-50, Method: Compositional matrix adjust. Identities = 121/274 (44%), Positives = 162/274 (59%), Gaps = 7/274 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLV-VELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LR+ TR SPLAL QAH + D + A+ G E+V T GD + L GGKGLF + Sbjct: 13 LRLGTRGSPLALAQAHQIADGIRAASAGAYDCEIVAFTTTGDKLTTERLINSGGKGLFTR 72 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 EL+ AL D+AVHS+KDVP P G +REDPRD F+S+ S+ LP G+ Sbjct: 73 ELDDALSRGELDLAVHSLKDVPSVLPPGQIFAAFPKREDPRDGFLSHGAKSIQDLPEGAT 132 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GT+SLRR+ Q RPDL + + RGNV TR+ KL+ G DA LA+AGL RLGL S + Sbjct: 133 LGTASLRREAQALALRPDLKVVTFRGNVATRMRKLEEGLADATFLAMAGLTRLGL-SEVA 191 Query: 185 AALPPEISLPAVGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 +P E LPA GQG +G+ R D D+ E+L L+H + + AERA +L+G C+ Sbjct: 192 TPIPLEDMLPAAGQGIIGVVTRDDVDTELLEILGQLSHEPSRVAAIAERAFLEKLDGSCR 251 Query: 244 VPIGSYAELID-GEIW-LRALVGAPDGSQIIRGE 275 PI ++ L D G+ W L V +P G+ RG+ Sbjct: 252 TPIAAH--LFDRGDEWQLIGEVLSPGGTTRWRGD 283 >UniRef50_A5VM67 Porphobilinogen deaminase n=9 Tax=Lactobacillus RepID=HEM3_LACRD Length = 305 Score = 199 bits (507), Expect = 8e-50, Method: Compositional matrix adjust. Identities = 119/296 (40%), Positives = 168/296 (56%), Gaps = 4/296 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + N + + +R+S LA+ Q V L P + E+ ++T GD LAK+GGKG+ Sbjct: 1 MTNKVIVGSRKSKLAMAQTELVIASLEKIFPDIKFEIKNVITEGDRNRHVSLAKIGGKGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS-NNYDSLDALP 120 FVKE+E L + D AVHS+KDV P+ L L +R P D VS N SL+ LP Sbjct: 61 FVKEIEDELKDGTIDFAVHSLKDVMPILPEELVLGAFPKRVSPYDCLVSRKNLSSLNDLP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GT+SLRRQ QL RPDL I +RGN+ TRL K+D D IILA AGL RL ++ Sbjct: 121 KGARIGTNSLRRQGQLLSIRPDLKIIPIRGNIDTRLRKIDTEALDGIILAEAGLTRLNID 180 Query: 181 SRIRAALPPE-ISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 L + +PAVGQG + IECR +D+R R++L +N E+A V ER L Sbjct: 181 LSSYHVLDLQNYIMPAVGQGCLAIECRKNDTRIRKMLDQINDEESAYCVQVEREFMRELG 240 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295 G C PIG +A +G+I L+ +P+G +I+ + P + +G +A++LL Sbjct: 241 GSCNFPIGGHAYAKNGQILFDGLIASPNGEHVIKETK--IPANNSGVGKKVADQLL 294 >UniRef50_Q47LA7 Porphobilinogen deaminase n=3 Tax=Actinomycetales RepID=HEM3_THEFY Length = 320 Score = 199 bits (507), Expect = 9e-50, Method: Compositional matrix adjust. Identities = 128/312 (41%), Positives = 177/312 (56%), Gaps = 11/312 (3%) Query: 7 RIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66 R+ TR+S +A Q+ V + L A G+ VELV + + GD I L ++GG G+FV L Sbjct: 7 RLGTRRSTMATNQSRRVAEILTA-RTGVPVELVLITSFGD-ITRAHLTQLGGTGVFVSAL 64 Query: 67 EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126 ALL + AVHS+KD+P +G+ L + ER+DPRDA + + LP G+ VG Sbjct: 65 RDALLAGEVEFAVHSLKDLPTAPTEGIVLAAVTERDDPRDALCARDGLKFADLPPGATVG 124 Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAA 186 T S RR QLA RPDL +RGN TRL K+ +GE DA++LA AGL R+G + Sbjct: 125 TGSPRRVAQLAALRPDLRYVPIRGNAETRLGKVASGELDAVVLAYAGLHRVGRLDDVTDV 184 Query: 187 LPPEISLPAVGQGAVGIECRLDD-SRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 + LPA GQGA+ +ECR D + L A++H T VTAER + LE GC P Sbjct: 185 FDVDQVLPAPGQGALAVECRTADFTGPLRYLTAVDHLPTRAAVTAERVILAELEAGCAAP 244 Query: 246 IGSYAELI-DGEIWLRALVGAPDGSQIIRGERR-------GAPQDAEQMGISLAEELLNN 297 +G+YAE + + + LRA V A DGSQ +R E+ A Q A +G LA +++ Sbjct: 245 VGAYAEFVAEDRLRLRAAVVATDGSQAVRAEQTVTVTEFPDAVQAATALGRQLAHDMIEQ 304 Query: 298 GAREILAEVYNG 309 GA +I+A+ G Sbjct: 305 GADQIVADAAAG 316 >UniRef50_C0YV01 Hydroxymethylbilane synthase n=1 Tax=Chryseobacterium gleum ATCC 35910 RepID=C0YV01_9FLAO Length = 302 Score = 199 bits (506), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 114/304 (37%), Positives = 172/304 (56%), Gaps = 12/304 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LALWQA V L ++ + E+VP+V+ GD L+ PL +G G+F ++ Sbjct: 4 IRIGTRNSALALWQAREVARHLQNNN--YLTEIVPIVSSGDKNLNQPLYSLGITGVFTRD 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDSLDALPAG 122 L++ALL + DIAVHS+KDVP + PQ + ++ ER+ P+D + S+ L Sbjct: 62 LDIALLNDEIDIAVHSLKDVPTQLPQNIEMIAYLERDYPQDILIRKESSRNKEFHELK-- 119 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 + TSSLRR+ P +RGN+ TRL KL+ G++DA IL++AG+KR+ +E Sbjct: 120 --LATSSLRRRAFWLRNYPTAEFSDIRGNIQTRLQKLEEGDFDATILSLAGIKRMKMEID 177 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 LP IS P+ QG + + D E++ +NH ET + V ER + LEGGC Sbjct: 178 YEM-LPLMISAPS--QGVISVAGHTDKPEINEIVRQINHQETQICVEIERNFLSTLEGGC 234 Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 PIG++AE+I +I +A + + DG I + AE G A+ +L NG +E+ Sbjct: 235 TAPIGAFAEIIGDQIRFKAALCSLDGKNCIAVDENFVYTPAENFGEKYAKVVLENGGKEL 294 Query: 303 LAEV 306 +AE+ Sbjct: 295 MAEI 298 >UniRef50_D0NJW2 Porphobilinogen deaminase n=2 Tax=Phytophthora infestans T30-4 RepID=D0NJW2_PHYIN Length = 361 Score = 199 bits (506), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 123/310 (39%), Positives = 172/310 (55%), Gaps = 11/310 (3%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG---GKGLFVK 64 +++R+S LA+ Q + V L P L + T GD +LD L+ +G GLF K Sbjct: 18 VSSRKSQLAMAQTNTVIAMLEERFPDLQFVVGQEDTVGDQVLDRHLSDLGTTTASGLFTK 77 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV------SNNYDSLDA 118 LE ALL A AVHS+KD+P P GL L I +RE P DA V +L Sbjct: 78 SLEEALLAKAASFAVHSLKDMPTTLPDGLVLAAITKRESPEDAAVIHPKHKEKGIKTLQE 137 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD-NGEYDAIILAVAGLKRL 177 LP GS++GTSSLRR+ L + P I+++RGN+ TRL+KLD + +YDAII+A G +R Sbjct: 138 LPEGSVIGTSSLRREALLRSQFPTFEIKTVRGNIQTRLAKLDEHDDYDAIIVAACGFRRG 197 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 L RI LP + VGQG++G+ECR DD T E+L + ++A AER++ Sbjct: 198 ELGDRIDEILPMDTFGYGVGQGSIGVECRADDEETIEMLKTITDEKSAQLCKAERSLLYH 257 Query: 238 LEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 LEGGCQ+ +G A L + + L A V + DG + + G E++G LAE NN Sbjct: 258 LEGGCQIAMGVSATLDEDTLTLNATVLSRDGKESVHETISGPRTQCEELGKQLAERFWNN 317 Query: 298 G-AREILAEV 306 AR++L + Sbjct: 318 ELARKVLGKT 327 >UniRef50_Q82P95 Porphobilinogen deaminase 2 n=14 Tax=Actinomycetales RepID=HEM32_STRAW Length = 314 Score = 199 bits (505), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 124/306 (40%), Positives = 169/306 (55%), Gaps = 4/306 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 ++RI +R SP+AL Q V+ +L A HP E+V + T GD + L+KV GKG F Sbjct: 8 ELIRIVSRDSPMALAQVARVRAELAALHPRTRTEVVAVKTTGDKWMGD-LSKVDGKGAFT 66 Query: 64 KELEVALLENRADIAVHSMKDVPVE--FPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 KE++ ALL AD+AVH +KDVP + P G +R+D RDA V +LD LP Sbjct: 67 KEVDAALLAGEADLAVHCVKDVPADRPLPAGTMFAAFLKRDDIRDALVHPGGLTLDELPP 126 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ +GTSS+RR QLA P L RGN RL KL GE DA++LAV+GL+R+G E Sbjct: 127 GTRIGTSSVRRVAQLAAAYPHLECVPFRGNANRRLEKLAAGEADALLLAVSGLERIGRED 186 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 I L PE +P +G G + ++CR D+ E ++ L T TAER L+G Sbjct: 187 VITEVLEPETMMPPIGAGILALQCREGDTGLIETISELGDPGTHREATAERMFLHVLQGH 246 Query: 242 CQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 C PI YA +GE+ LRA V DG ++ D +G S+A LL GAR Sbjct: 247 CNSPIAGYARTERNGELSLRASVFTLDGKTVLNAHEWAGRLDPATLGTSVAVALLRQGAR 306 Query: 301 EILAEV 306 E++ ++ Sbjct: 307 ELIDDI 312 >UniRef50_C6R3Y0 Hydroxymethylbilane synthase n=1 Tax=Rothia mucilaginosa ATCC 25296 RepID=C6R3Y0_9MICC Length = 377 Score = 198 bits (504), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 142/370 (38%), Positives = 192/370 (51%), Gaps = 73/370 (19%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMA------SHPG------LVVELVPMVTRGDVI 48 M + + TR S LAL Q+ + + + +H G + EL + T GDV Sbjct: 1 MSHHEYTLGTRGSALALTQSRIAAETVTSLYTEHQAHHGAENPEAVSFELRTVKTEGDV- 59 Query: 49 LDTPLAKVGGKGLFVKELEVALL-------ENRADIAVHSMKDVPVEFPQGLGLVTICER 101 L PLA +GG G+F L LL ENR D+AVHS+KD+P GL + +R Sbjct: 60 LTGPLATLGGTGVFAAALRQRLLDGENASEENRVDMAVHSLKDLPSAPCPGLVVAATLKR 119 Query: 102 EDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD- 160 EDPRDA V+ + ++D LP GS VGT S RR QL RPDL I +RGNVGTR+ ++ Sbjct: 120 EDPRDALVARDGLTVDTLPEGSRVGTGSPRRAAQLRALRPDLEIVDVRGNVGTRIGRVKG 179 Query: 161 -----------------------------NGEYDAIILAVAGLKRLGLESRIRAALPPEI 191 +G+ DA++LAV+GLKRLG E I L P Sbjct: 180 LEEHAGKQVVLRQNAETSERADHGVGTERSGDCDAVVLAVSGLKRLGKEELITEYLDPTR 239 Query: 192 SLPAVGQGAVGIECRLDDSRT-------------------RELLAALNHHETALRVTAER 232 LPA GQGA+ +E R + R LLAA NHHET L V+AER Sbjct: 240 MLPAPGQGALALEVRESEFENPDSAVLADPEVARPVRALGRALLAA-NHHETRLAVSAER 298 Query: 233 AMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---AEQMGIS 289 A+ RLE GC PIG+YA +++G++ L +V +PDG+ ++R A D AE++G+ Sbjct: 299 ALLRRLEAGCAAPIGAYAHVVEGDLVLNVVVASPDGTDMLRHTSATAELDVPGAERLGVR 358 Query: 290 LAEELLNNGA 299 +AE+LL GA Sbjct: 359 VAEDLLQMGA 368 >UniRef50_Q8RFP5 Porphobilinogen deaminase n=16 Tax=Fusobacteriaceae RepID=HEM3_FUSNN Length = 298 Score = 198 bits (504), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 118/273 (43%), Positives = 160/273 (58%), Gaps = 5/273 (1%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPL--AKVGG 58 M N++ I +R S LAL QA+ VKD+L ++P L E+ +VT GD L + + + Sbjct: 1 MKKNII-IGSRGSILALAQANLVKDRLQGNYPNLSFEIKEIVTSGDKDLKSNWENSDISL 59 Query: 59 KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118 K F KE+E LL+ DIAVHSMKD+P + L I +REDPRD VS N L Sbjct: 60 KSFFTKEIEQELLDGEIDIAVHSMKDMPAVSAKSLICGAIPDREDPRDVLVSKN-GLLVT 118 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 LP G+ VGTSSLRR L RPD I+ LRGN+ TRL KL+ +YDAI+LA AGLKR G Sbjct: 119 LPQGAKVGTSSLRRAMNLKTVRPDFEIKHLRGNIHTRLKKLETEDYDAIVLAAAGLKRTG 178 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 L +I L E+ PA QG + I+CR +D +E+L ++++ A V ER + Sbjct: 179 LADKITEYLNGEVFPPAPAQGVLYIQCRENDEEIKEILKSIHNEAIAKIVEIEREFSKIF 238 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQI 271 +GGC P+G Y+++ +I A V +G QI Sbjct: 239 DGGCHTPMGCYSQVNGDKIKFTA-VYLDEGKQI 270 >UniRef50_C9RPT6 Porphobilinogen deaminase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RPT6_FIBSS Length = 351 Score = 198 bits (503), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 122/280 (43%), Positives = 157/280 (56%), Gaps = 30/280 (10%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHP-------------GLVVELVPMVTRGDV 47 M D LRIATR+S LAL Q D ++A++ L ELV M T GD Sbjct: 1 MSDLKLRIATRKSALALAQTTMAADAIVAANSVIGNAADSNNARDSLTYELVSMTTEGDR 60 Query: 48 ILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDA 107 LD LA GGKG+F+KELE+ALLE RADIA+HS+KD+P E L + +REDPRDA Sbjct: 61 RLDKSLASFGGKGVFIKELEIALLEGRADIAIHSLKDMPAEVLPQFKLAAVLKREDPRDA 120 Query: 108 FVSNNYDS---LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY 164 F+S + LPAG+ VGT S+RR QL RPDL +RGN+ TR+ KL E Sbjct: 121 FLSRGGSAGIRFMDLPAGARVGTGSIRRVVQLKALRPDLEYVPIRGNIQTRIGKL--AEL 178 Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRE---------- 214 D ++LA AGLKR+GL ++ E LPA GQG + IE L+D+ +E Sbjct: 179 DGVVLAAAGLKRMGLADQVTEYFSTEQMLPASGQGILAIET-LNDATVQESRVTGRADLA 237 Query: 215 -LLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELI 253 +LA +N T +AE A L GCQ P+ S+AE + Sbjct: 238 QILARVNDVATYCIASAEMAYLKALNAGCQFPVASFAEFV 277 >UniRef50_A4CHM3 Porphobilinogen deaminase n=4 Tax=Bacteroidetes RepID=A4CHM3_9FLAO Length = 315 Score = 197 bits (502), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 129/322 (40%), Positives = 171/322 (53%), Gaps = 25/322 (7%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + LRI TR S LALWQA V+D+L A+ G ELVP+ + GD++LD PL ++G G+ Sbjct: 1 MSRALRIGTRDSELALWQAQTVRDRLEAA--GHRAELVPVKSTGDLVLDKPLYELGITGI 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F K L+VALL D+AVHSMKDVP P+G+ + ER RD V LD Sbjct: 59 FTKTLDVALLREDIDLAVHSMKDVPTALPEGICQAAVLERASARDVLVHKGLGFLDG--P 116 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+I T SLRR+ Q R P + LRGNV TRL L +D I A AGL+R+GL Sbjct: 117 GTIA-TGSLRRKAQWLNRYPAHQVTGLRGNVNTRLKLLRENSWDGAIFAQAGLERIGLLP 175 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 A P + LPA QGA+ + R D+ RE L+H ++AL V ER LEGG Sbjct: 176 --DNAEPLDWMLPAPAQGAMLVVARTSDTAAREAARPLHHEQSALEVAVEREFLRTLEGG 233 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAP-----------QDAEQMGISL 290 C PIG+ DG++ L + + DG + R R QDA + G + Sbjct: 234 CSAPIGARVHAADGQLHLEGGLFSLDGKKAFRVTRHTGSLEAGGTGDARFQDAGEFGAAC 293 Query: 291 AEELLNNGA-------REILAE 305 A E+L++G R+ILA+ Sbjct: 294 AREILDSGGAVLMESIRKILAQ 315 >UniRef50_D2NS36 Porphobilinogen deaminase n=2 Tax=Micrococcaceae RepID=D2NS36_9MICC Length = 454 Score = 197 bits (501), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 142/363 (39%), Positives = 187/363 (51%), Gaps = 73/363 (20%) Query: 8 IATRQSPLALWQAHYVKDKLM-------ASHPGLVVELVPMV-----TRGDVILDTPLAK 55 + TR S LAL Q+ + + A H E+V T GDV L PLA Sbjct: 85 LGTRGSALALTQSRIAAETVTSLYTEHQAHHGAADAEVVDFTLRTVKTEGDV-LTGPLAT 143 Query: 56 VGGKGLFVKELEVALL-------ENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAF 108 +GG G+F L LL ENR D+AVHS+KD+P GL + +REDPRDA Sbjct: 144 LGGTGVFAAALRQRLLDGENASEENRVDMAVHSLKDLPSAPCPGLVIAATLKREDPRDAL 203 Query: 109 VSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD-------- 160 V+ + +LD LP GS VGT S RR QL RPDL I +RGNVGTR+ ++ Sbjct: 204 VARDGLTLDTLPEGSRVGTGSPRRAAQLRALRPDLEIVDIRGNVGTRIGRVKGLEEHAGK 263 Query: 161 ----------------------NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQ 198 +G+ DA++LAV+GLKRLG E I L P LPA GQ Sbjct: 264 QVVLRQNTETSERADHGVGTERSGDCDAVVLAVSGLKRLGKEELITEYLDPTRMLPAPGQ 323 Query: 199 GAVGIECRLDDSRT-------------------RELLAALNHHETALRVTAERAMNTRLE 239 GA+ +E R + R LLAA NHHET L V+AERA+ RLE Sbjct: 324 GALALEVRESEFENPDPAVLADPEVARPVRALGRALLAA-NHHETRLAVSAERALLRRLE 382 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---AEQMGISLAEELLN 296 GC PIG+YA +++G++ L +V +PDG+ ++R A D AE++G+ +AE+LL Sbjct: 383 AGCAAPIGAYAHVVEGDLVLSVVVASPDGTDMLRHTSATAELDVPGAERLGVRVAEDLLQ 442 Query: 297 NGA 299 GA Sbjct: 443 MGA 445 >UniRef50_Q7UPN0 Porphobilinogen deaminase n=1 Tax=Rhodopirellula baltica RepID=HEM3_RHOBA Length = 337 Score = 197 bits (501), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 132/325 (40%), Positives = 189/325 (58%), Gaps = 27/325 (8%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LRIATR+SPLA+WQA +V KL+ H G E+VP+V++GD + P+ GLF K Sbjct: 12 LRIATRESPLAMWQAEHVA-KLLKKH-GFQTEIVPLVSKGDTDM-RPIDGTRQVGLFTKR 68 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV----SNNYDS------ 115 ++ AL+++ AD+AVHS+KD+P E L + RE DA V S + +S Sbjct: 69 IQQALVDDEADVAVHSLKDLPTEPDSRFVLAAVPPRESVLDALVFADNSPHLESQTGAES 128 Query: 116 -LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174 LD LP G+ VGT S RR QL + RPDL + +RGNV TRL+KL+ GE+DAI+LA AG+ Sbjct: 129 PLDYLPQGARVGTGSTRRLAQLKQLRPDLEVLPIRGNVQTRLAKLNAGEFDAIVLAHAGI 188 Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234 RL + P + +PA GQGA+GIE R DD+ + +A LN L TAER + Sbjct: 189 LRLEMTDLPHRLFPLDEMIPAPGQGALGIEVRSDDAGAMDAIANLNDAAARLAATAERKV 248 Query: 235 NTRLEGGCQVPIGSYAELIDG----EIWLRALVGAPDGSQIIRGERRGAPQ--------- 281 + L GGC PI +A+L E+ LRA+V + DG Q ++ + R Q Sbjct: 249 LSELHGGCLAPIACHAKLETSNHGTELCLRAIVMSADGEQRLQEDARITVQPNDADLHVA 308 Query: 282 DAEQMGISLAEELLNNGAREILAEV 306 +A ++G +A+ L + GA ++++ V Sbjct: 309 EAHELGTLVAKRLRDKGADKLISTV 333 >UniRef50_B5G8F1 Porphobilinogen deaminase n=1 Tax=Streptomyces sp. SPB74 RepID=B5G8F1_9ACTO Length = 314 Score = 196 bits (498), Expect = 8e-49, Method: Compositional matrix adjust. Identities = 129/310 (41%), Positives = 173/310 (55%), Gaps = 13/310 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR SPLAL Q V L P L +E+VP+ T+ D LA++GGKGLFV+E Sbjct: 1 MRIGTRSSPLALAQVEQVSGLLRKFEPDLDIEVVPVTTKADK-WQGDLAQLGGKGLFVRE 59 Query: 66 LEVALLENRADIAVHSMKDVP--VEFPQGLGLVTICEREDPRDAFV---SNNYDSLDALP 120 ++ L + D+AVH MKDVP V P+GL R+D RD + ++ SL LP Sbjct: 60 IDQMLQRGQVDMAVHCMKDVPGDVPMPRGLIFAAYLPRDDVRDVLLVPEGSDVQSLAGLP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-----YDAIILAVAGLK 175 G+ V TS++RR+ Q+ RPDL + +RG VG+R+ KLD + DA++LA AGL+ Sbjct: 120 PGASVATSAVRRKAQINRVRPDLNVVRVRGLVGSRIDKLDGRKPMDHMLDAMVLARAGLE 179 Query: 176 RLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235 RL L R R LPAVG GA+G+ECR DD LL LN T +TAER M Sbjct: 180 RLDLMHRARQVFEVAEMLPAVGAGALGLECREDDDAVAYLLQQLNDEPTMTEITAERVML 239 Query: 236 TRLEGGCQVPI-GSYAELIDGEIWLRALVGAPDGSQIIRGERRG-APQDAEQMGISLAEE 293 L G C PI G DG++ LR +V + DGS+ + G + D +G + E Sbjct: 240 HGLRGHCNSPIAGHCVTDPDGQLSLRGMVFSRDGSKFVHAHFWGESMNDPAVLGSRVCAE 299 Query: 294 LLNNGAREIL 303 LL GAR+I+ Sbjct: 300 LLRQGARDII 309 >UniRef50_C6XGK7 Porphobilinogen deaminase n=1 Tax=Candidatus Liberibacter asiaticus str. psy62 RepID=C6XGK7_LIBAP Length = 307 Score = 196 bits (498), Expect = 9e-49, Method: Compositional matrix adjust. Identities = 112/291 (38%), Positives = 161/291 (55%), Gaps = 2/291 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 RI TR SPLAL A + LM H P + ++P+ T+GD I + L ++GGKGLF Sbjct: 6 FRIGTRCSPLALAHAFETRSSLMDVHKIPPHNIVIIPLSTKGDRITNRTLTEIGGKGLFT 65 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 +E+E L+ D AVHS KD+P + +GL + RED RD F+S+ SL L S Sbjct: 66 EEIEKKLISGEIDCAVHSAKDMPTKLLKGLQISAYLPREDIRDVFISHTAQSLKDLALHS 125 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 ++GTSSLRR+ L R D+ + RG + TRL+KL+N + AI+LA AG+KRL E I Sbjct: 126 VIGTSSLRRKALLLRWRSDISVIDFRGKIETRLNKLNNNKAHAILLAYAGIKRLKKEKVI 185 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + L E P+ GQGA+ IE +++ + +EL+ +NH +T V ERA L+G C+ Sbjct: 186 KEILNIEDFPPSPGQGAICIETHVNNPKAQELVKVINHEDTWDSVNCERAFLAELDGSCK 245 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 I +A ++ +V A DG R G DA +G A+ + Sbjct: 246 SAIAGFAYCKGSTLYFYGIVLASDGKIFHEVSRNGNRCDAINIGRDAAQYI 296 >UniRef50_UPI0001926E0E PREDICTED: similar to hydroxymethylbilane synthase, partial n=1 Tax=Hydra magnipapillata RepID=UPI0001926E0E Length = 418 Score = 196 bits (498), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 111/269 (41%), Positives = 150/269 (55%), Gaps = 4/269 (1%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67 + +R+S LA+ Q + L + + M T GD IL L K+G K LF K+LE Sbjct: 33 VGSRKSQLAVIQTKSIVAALCQKEKDVECIIETMDTLGDKILHIALPKIGEKSLFTKDLE 92 Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDSLDALPAGSI 124 +AL E R D VHS+KD+P PQG+ + TI +R+DPRD + +N L LP SI Sbjct: 93 LALSEKRVDFLVHSLKDLPTTLPQGMAISTIYKRDDPRDCIIFHPKHNGKKLADLPENSI 152 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-YDAIILAVAGLKRLGLESRI 183 +GTSSLRR QL + L +S+RGN+ TRL KL+ YDAI+LA AG+ R+G +I Sbjct: 153 IGTSSLRRVAQLKRKYNKLTFQSVRGNLNTRLQKLEEESLYDAIVLAKAGVDRMGWTEKI 212 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 L + L A+GQGA+ +E R DD T +LA L ET L AER L GGC Sbjct: 213 GQILSEDECLYAIGQGAITVEVRNDDKYTISILAQLTDMETLLACVAERCFMRTLNGGCS 272 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQII 272 PI +++ LR +V DGS+ + Sbjct: 273 TPIACHSQFSGNNYSLRGIVLNADGSRFL 301 >UniRef50_C3WGN0 Porphobilinogen deaminase n=5 Tax=Fusobacterium RepID=C3WGN0_9FUSO Length = 301 Score = 196 bits (498), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 122/305 (40%), Positives = 172/305 (56%), Gaps = 13/305 (4%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG--KGLFVKE 65 I +R S LAL QA VK+ L A++P L E+ +VT GD L + K F KE Sbjct: 7 IGSRGSILALAQASLVKNSLEANYPDLTFEIKEIVTSGDKDLKSNWENSNASLKSFFTKE 66 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E LL+ + DIAVHSMKD+P P+GL I +RED RD +S N L LP G+ + Sbjct: 67 IEQELLDGQIDIAVHSMKDMPAVSPKGLICGAIPDREDARDVLISKN-GFLVTLPQGAKI 125 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR L RPD I+ LRGN+ TRL KL+ +YDAIILA AGLKR G+ +I Sbjct: 126 GTSSLRRVMNLKAIRPDFEIKHLRGNIHTRLKKLETEDYDAIILAAAGLKRTGMADKITE 185 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L E PA QG + I+CR +D + +L ++++ + A V ER + +GGC P Sbjct: 186 YLSGEAFPPAPAQGVLYIQCRENDEEIKGILKSIHNEDIAKIVEIEREFSKIFDGGCHTP 245 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 +G Y+++ + +I A + DG QI R +D ++ +E+ + A EI A+ Sbjct: 246 MGCYSQVDEDKIKFIAAY-SHDGKQI-----RVVIED----DLTKGKEIAHMAAEEIKAK 295 Query: 306 VYNGD 310 + G+ Sbjct: 296 INKGN 300 >UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia (class) RepID=B9L0Q4_THERP Length = 560 Score = 195 bits (496), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 125/289 (43%), Positives = 162/289 (56%), Gaps = 4/289 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI +R S LAL Q V ++L P V +VP+VT GD T L +GG G+F KE Sbjct: 5 IRIGSRGSTLALAQTEEVVERLRRLVPECSVTVVPIVTTGDRDRATSLTVLGGSGVFAKE 64 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L ALL D+AVHS KD+P + P GL LV + RED RD V++ L LPAG+ V Sbjct: 65 LHEALLAGTIDLAVHSAKDLPTQLPPGLVLVAVLAREDARDVLVTSPPRKLGELPAGARV 124 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS RRQ L RPDLI+ +RGNV TRL KL G DA++L AGL+RL + Sbjct: 125 GTSSRRRQALLQRARPDLIVVDIRGNVDTRLRKLREGIVDALVLGAAGLRRLSQADLVAE 184 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L P+ +PA GQGA+ + R D R ELL+ L+ V ERA GC VP Sbjct: 185 YLDPDEFVPAPGQGALAVVARESDGRL-ELLSRLDEPLVHEAVAVERAFLAAFGSGCSVP 243 Query: 246 IGSYAELIDGEIWLRALVGAPDG---SQIIRGERRGAPQDAEQMGISLA 291 +G+YA + + R V PDG SQ + R A + A ++G++LA Sbjct: 244 LGAYATIAGNRLRFRIAVLLPDGRFISQCLDWPREEAIERARELGLTLA 292 >UniRef50_C6XST0 Porphobilinogen deaminase n=2 Tax=Pedobacter RepID=C6XST0_PEDHD Length = 526 Score = 194 bits (494), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 119/264 (45%), Positives = 159/264 (60%), Gaps = 16/264 (6%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L I TR S LALWQA+++KDKL A G+ EL + T+GD IL+ L K+ GKG F KE Sbjct: 4 LIIGTRGSDLALWQANFIKDKLAAI--GVEAELKIIKTQGDKILNLRLDKLEGKGFFTKE 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAF------VSNNYDSLDAL 119 LE LL DIAVHS KD+P P GL + + EREDP + VS N+ +L Sbjct: 62 LEEELLGGTIDIAVHSHKDLPTVHPAGLTIAAVTEREDPSELLLILKDCVSINHKL--SL 119 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 G++VGTSS RR+ QL RPDL I LRGNV TR+ KL + +YDAI+LA AG+ RL + Sbjct: 120 KKGAMVGTSSNRRKAQLLALRPDLNIEDLRGNVPTRIQKLRDEDYDAILLARAGVNRLNI 179 Query: 180 ---ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236 E + E+ +PA QGA+ I+ R +++ ++L +NH ETA + ER + Sbjct: 180 DLSEFHVEVVDTTEL-VPAPAQGALAIQIRENENELFDILQQINHSETAEEIAIERKVLN 238 Query: 237 RLEGGCQVPIGSYAELIDG--EIW 258 EGGC +P+G Y + DG E+W Sbjct: 239 LFEGGCHMPLGCYCKKEDGQYEVW 262 >UniRef50_C5RMN3 Porphobilinogen deaminase n=1 Tax=Clostridium cellulovorans 743B RepID=C5RMN3_CLOCL Length = 300 Score = 194 bits (493), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 121/310 (39%), Positives = 175/310 (56%), Gaps = 16/310 (5%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + ++RI TR+S LAL Q + V D + HP + E+V M T+GD ILD L GGKG Sbjct: 1 MKKIIRIGTRKSKLALMQTNIVIDAIKKKHPEINCEVVEMSTKGDEILDKSLLSFGGKGA 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS-NNYDSL-DAL 119 FV E E A+ D+AVHS KD+P++ GL +V + +REDPRD V+ NN D++ D Sbjct: 61 FVSEFEKAIKSGEIDLAVHSAKDMPMDLLTGLKIVAVTKREDPRDVLVTANNKDTINDFN 120 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 ++GT+SLRR+ Q+ ++ + LRGNV RL KL +GEYD IILA AGLKRLGL Sbjct: 121 KTNKLIGTTSLRRKLQIKRLLNNVDTKDLRGNVQRRLEKLISGEYDGIILAAAGLKRLGL 180 Query: 180 --ESRIR-AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236 + RI L E +PA GQG + +E R ++ + L ++++ E + ER + Sbjct: 181 LDDERINLNYLSVEDFIPAGGQGIIAVEGRAEEEFSF-LKDSIHNEEAMYSLEVERYVMK 239 Query: 237 RLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 +L GC PIG+Y+ ID + ++ +G R D+ + + L E+L+ Sbjct: 240 KLNAGCNEPIGAYS-FIDKDTIFLDIIYEHNGKV-----SRKKGSDSIENRLKLTEKLV- 292 Query: 297 NGAREILAEV 306 EIL EV Sbjct: 293 ---EEILQEV 299 >UniRef50_P28789 Porphobilinogen deaminase n=18 Tax=Saccharomycetales RepID=HEM3_YEAST Length = 327 Score = 194 bits (493), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 122/317 (38%), Positives = 178/317 (56%), Gaps = 15/317 (4%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 L I R+S LA+ Q+++V + +P ++ + T GD I PL GGK L+ K Sbjct: 5 TLHIGGRKSKLAVIQSNHVLKLIEEKYPDYDCKVFTLQTLGDQIQFKPLYSFGGKALWTK 64 Query: 65 ELEVALLEN----RADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDSLD 117 ELE L + + D+ VHS+KD+P P+G L I +R DP D V + Y SLD Sbjct: 65 ELEDHLYHDDPSKKLDLIVHSLKDMPTLLPEGFELGGITKRVDPTDCLVMPFYSAYKSLD 124 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAGLK 175 LP G IVGTSS+RR QL + P L S+RGN+ TRL KLD+ + Y IILA AGL Sbjct: 125 DLPDGGIVGTSSVRRSAQLKRKYPHLKFESVRGNIQTRLQKLDDPKSPYQCIILASAGLM 184 Query: 176 RLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235 R+GLE+RI + AVGQGA+GIE R D++ ++L + + +ERA+ Sbjct: 185 RMGLENRITQRFHSDTMYHAVGQGALGIEIRKGDTKMMKILDEICDLNATICCLSERALM 244 Query: 236 TRLEGGCQVPIGSYAELID--GEIWLRALVGAPDGSQIIRGE----RRGAPQDAEQMGIS 289 LEGGC VPIG ++ + ++ L+A+V +G++ + E +D+ G Sbjct: 245 RTLEGGCSVPIGVESKYNEETKKLLLKAIVVDVEGTEAVEDEIEMLIENVKEDSMACGKI 304 Query: 290 LAEELLNNGAREILAEV 306 LAE ++ +GA++IL E+ Sbjct: 305 LAERMIADGAKKILDEI 321 >UniRef50_Q09899 Porphobilinogen deaminase n=2 Tax=Schizosaccharomyces RepID=HEM3_SCHPO Length = 336 Score = 192 bits (489), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 126/314 (40%), Positives = 179/314 (57%), Gaps = 16/314 (5%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG---GKGLFVK 64 I TR+S LA+ Q+ ++++L +P L ++ T GD IL L + K L+ + Sbjct: 9 IGTRKSKLAVIQSEIIREELEKHYPHLEFPIISRDTIGDEILSKALFEFKRQLAKSLWTR 68 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDSLDALPA 121 ELE L+ N+ I VHS+KD+P E P G+ + I +R P DA V ++Y ++ LP Sbjct: 69 ELEALLVTNQCRILVHSLKDLPSEMPDGMVIACIPKRSCPLDAIVFKAGSHYKTVADLPP 128 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLKRLGL 179 GS+VGTSS+RR+ LA P L +RGNVGTRL+KLD + ++D ++LA AGL RLGL Sbjct: 129 GSVVGTSSIRRRALLARNFPHLRFVDIRGNVGTRLAKLDAPDSQFDCLVLAAAGLFRLGL 188 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 + RI L AVGQGA+ +E R DD E+L L H ET AERA+ RL+ Sbjct: 189 KDRIAQMLTAPFVYYAVGQGALAVEVRADDKEMIEMLKPLQHQETLYACLAERALMKRLQ 248 Query: 240 GGCQVPIGSYAELI-----DGEIWLRALVGAPDGSQIIRGE---RRGAPQDAEQMGISLA 291 GGC +PIG +++ I L V + DG + G + ++AE++GI++A Sbjct: 249 GGCAIPIGVQTDVLAISNSSYRISLLGTVLSADGLRAAFGNAEAVVSSEEEAEELGITVA 308 Query: 292 EELLNNGAREILAE 305 LL NGA IL E Sbjct: 309 LALLKNGAGPILEE 322 >UniRef50_A0DD68 Chromosome undetermined scaffold_46, whole genome shotgun sequence n=2 Tax=Paramecium tetraurelia RepID=A0DD68_PARTE Length = 306 Score = 192 bits (487), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 119/275 (43%), Positives = 159/275 (57%), Gaps = 10/275 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTR-GDVILDTPLAKVGGKGLFVK 64 LRIATR S LA+ Q +YV +L E++ + GDV L PL ++ G+F K Sbjct: 5 LRIATRSSALAMAQTNYVISELKQE-----CEIIKVSNEVGDVNLQDPLYQMPTVGVFTK 59 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALPA 121 ++E LLE +AD+AVHS+KD+P L L + E D + N NY SL LP Sbjct: 60 QVEQYLLEQKADVAVHSLKDLPTIIDAQLHLAAYTKFEQRGDVVLLNKKYNYKSLSELPD 119 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G VGTSSLRR + R P L + ++RGN+ TR+ KLD G+YDAIILA AG+ RLGL Sbjct: 120 GLKVGTSSLRRIATIRSRYPKLNLINIRGNLNTRIQKLDEGQYDAIILAKAGILRLGLAE 179 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 +I L + L A Q A+GI+CR DD T L LN + R AER LEGG Sbjct: 180 KISFDLDEKEFLYAPAQAALGIQCRKDDLETIGRLQILNDTDAQKRCVAERMFLNLLEGG 239 Query: 242 CQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGE 275 C++PI Y+E DG+++++ V A DGS++I E Sbjct: 240 CRLPIAVYSECREDGQVYIKGRVLAVDGSKVIEDE 274 >UniRef50_A8MGE4 Porphobilinogen deaminase n=30 Tax=cellular organisms RepID=HEM3_ALKOO Length = 296 Score = 191 bits (485), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 114/291 (39%), Positives = 162/291 (55%), Gaps = 9/291 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +R+ +R+S LA+ Q+ V + + P + +ELV M T GD+ LD L K+GGKGLF+KE Sbjct: 3 IRVGSRESKLAVKQSEIVIEAIRKYDPNIEIELVTMKTTGDIKLDQTLDKIGGKGLFIKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L+ AL ++R DI VHS KD+P+ + L +V + +REDPRD V ++ + Sbjct: 63 LDQALYDDRVDITVHSFKDMPMAIDEYLPIVAVSKREDPRDVLVLPK--TVKEPDFSKPI 120 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 G SS RR+ QL E P + +RGNV TRL KLD GE+ AI LA+AGLKRLGLE RI Sbjct: 121 GCSSFRRKIQLQEIYPHCSVEPIRGNVLTRLEKLDRGEFSAITLALAGLKRLGLEERISR 180 Query: 186 ALPPEISLPAVGQGAVGIECR--LDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 LPA QG + ++ R D S L+ + E AER+ L GGC Sbjct: 181 IFEVTEILPAACQGVIVVQARKGFDVS----FLSDFHDKEAWDISMAERSFVRTLNGGCS 236 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 P+ +Y E+ D + L L + + + GA + E+MG +LA ++ Sbjct: 237 SPVAAYGEIKDNYLTLTGLY-VDSSNSVHKKTITGARKQGEEMGFNLALQM 286 >UniRef50_C0BZ93 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM 15053 RepID=C0BZ93_9CLOT Length = 298 Score = 191 bits (485), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 121/294 (41%), Positives = 164/294 (55%), Gaps = 7/294 (2%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + +++RI +R+S LA+ QA VK + + P + E+V M T GD ILD L GGKGL Sbjct: 1 MQSIIRIGSRESRLAVKQAEIVKQAVERNCPDIKAEIVTMKTEGDKILDRRLELAGGKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKELE ALL+ R DI VHS+KDVP+E P+ L +V EREDPRD + + ++P Sbjct: 61 FVKELEKALLDGRIDICVHSLKDVPMEVPEDLPVVAFGEREDPRDVLIYKPGRT--SIPE 118 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G ++GTSS RR+ QL P RS+RGNV TRL KL +D +LA AGLKRL +E Sbjct: 119 GGVIGTSSRRRELQLKRLYPSCTFRSIRGNVQTRLRKLSEEGFDGTVLAAAGLKRLHMEE 178 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + +PAVGQG + ++ R R L + ++ AER L GG Sbjct: 179 VAGRVFSVDEIIPAVGQGILAVQGR--KGRDYSWLTSFACGKSRAEAEAEREFAAALGGG 236 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD-AEQMGISLAEEL 294 C P+ ++A+ E+ L L G I R R D A Q+G +LAEE+ Sbjct: 237 CTSPVAAHAQAQGAELKLTGLYYC--GGDIYRTRTRTGETDRARQLGAALAEEM 288 >UniRef50_Q1AUK3 Porphobilinogen deaminase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=HEM3_RUBXD Length = 305 Score = 191 bits (485), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 121/266 (45%), Positives = 160/266 (60%), Gaps = 3/266 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L + TR SPLAL QA L A+ G VEL + T D D PL+ + + +F ++ Sbjct: 5 LVLGTRGSPLALAQAEACAAGLRAA--GFAVELRRIRTTSDRRPDDPLSVIDQRDVFTRQ 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L+ ALL D+AVHSMKDVP E P+G+ L + R DP DA VS +D LP G+ V Sbjct: 63 LDEALLAGEVDLAVHSMKDVPTEVPEGIVLAAVAGRADPSDALVSEGGWGVDGLPEGARV 122 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 TSSLRR+ QL RRPDL + +RGNV TR+ K+ G +A++LA AGL RLGLE A Sbjct: 123 ATSSLRRRAQLLHRRPDLRVVEIRGNVDTRIRKMRAGAAEAVVLARAGLVRLGLEV-PHA 181 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 +P ++ LPAVGQGA+ + R D R E+ ALN V AERA+ LEGGC+VP Sbjct: 182 VIPHDVLLPAVGQGALAVAVRRGDPRLEEIRRALNDPAAEREVAAERALLRALEGGCRVP 241 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQI 271 +G+ A + LR +V +PDG+ + Sbjct: 242 VGARAVAGGRGVLLRGVVVSPDGAAL 267 >UniRef50_C1TM53 Porphobilinogen deaminase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TM53_9BACT Length = 454 Score = 191 bits (484), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 118/262 (45%), Positives = 153/262 (58%), Gaps = 6/262 (2%) Query: 10 TRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVA 69 +R+S LA +A ++ + GL VE+ M T GD D L+ GG G FVK LE A Sbjct: 160 SRKSALA--RAQTMEAARALAKKGLPVEIKTMSTCGDEKQDCHLSAFGGNGAFVKCLEEA 217 Query: 70 LLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSS 129 ++E + D A+HS+KDVP P GL LV + R D VSN+ L+ LPAG++VGTSS Sbjct: 218 IMEGKGDGAIHSLKDVPSVLPDGLELVAVLPRASTSDVIVSNHKGGLEGLPAGAVVGTSS 277 Query: 130 LRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPP 189 LRR+ QLA RPDL +RGNV TRL+KL +G+ DAI+LA AGL RLG+ LP Sbjct: 278 LRRKAQLAITRPDLDYTLIRGNVNTRLAKLQSGDADAIVLAKAGLDRLGISPEGATTLP- 336 Query: 190 EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSY 249 LPA QG + +E R SR E A+NH T L AER + L+ GC VP + Sbjct: 337 --FLPAPCQGIIAVEAR-SGSRLAEEFRAINHRPTWLMALAERELLESLQVGCHVPFAAL 393 Query: 250 AELIDGEIWLRALVGAPDGSQI 271 +E + GE+ LRA + DG I Sbjct: 394 SEWVGGELRLRAQTLSYDGRHI 415 >UniRef50_B3RTQ8 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RTQ8_TRIAD Length = 314 Score = 191 bits (484), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 121/335 (36%), Positives = 175/335 (52%), Gaps = 64/335 (19%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M + V+RI TR+S LA+ Q H V D L HP +E+V M T GD +LD L ++G Sbjct: 4 MEETVVRIGTRKSQLAMIQTHSVVDALREIHPKARIEIVTMDTIGDRVLDKALPEIGQTN 63 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF K+LEVAL +N+ D+ +HS+KDVP P+GL + I Sbjct: 64 LFTKDLEVALTDNKIDLIIHSLKDVPSTLPEGLAIAAI---------------------- 101 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD-NGEYDAIILAVAGLKRLGL 179 G+++GTSSLRR QL R P L ++RGN+ TRL KLD +G YDA++LA AG++ Sbjct: 102 -GNVIGTSSLRRIAQLKRRFPHLKFENVRGNLNTRLKKLDESGIYDALVLAGAGVE---- 156 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 L P+ L A+GQGA+GIE R +D +T L++A ++ + AERA L+ Sbjct: 157 -------LTPDECLYAIGQGALGIEIRKNDKKTFSLISAYTDFDSLVCNAAERAFLRFLD 209 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIR-------------------------- 273 GC VPIG Y E + ++ + V + DGS+ ++ Sbjct: 210 KGCSVPIGVYTEFTENKLKITGAVFSLDGSKRVQYSDECTISGLNAKDDCESNYESLSSI 269 Query: 274 ---GERRGAPQDAEQMGISLAEELLNNGAREILAE 305 E + +AE++G +AE +L N E+LAE Sbjct: 270 LCPSEMCNSLIEAERLGKYVAEMILKNHGGEVLAE 304 >UniRef50_B0D5Q2 Predicted protein n=1 Tax=Laccaria bicolor S238N-H82 RepID=B0D5Q2_LACBS Length = 340 Score = 190 bits (483), Expect = 5e-47, Method: Compositional matrix adjust. Identities = 121/309 (39%), Positives = 170/309 (55%), Gaps = 10/309 (3%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67 I R S LA QA V+ +L P E+ I + + + GG L+ ELE Sbjct: 21 IGCRPSTLAKIQAELVRSRLKVLFPASRFEISSKKFPQPEIGTSQITERGGASLWTTELE 80 Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALPAGSI 124 AL + DI VHS+KDVP + +G ++ + ERED RD V + Y +L+ LPAGS+ Sbjct: 81 DALFDGDIDILVHSLKDVPTKLKEGCEIIHVLEREDRRDCLVVKDGLPYRTLEELPAGSV 140 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAGLKRLGLESR 182 VGT S+RR Q+ R P L+I+ +RGN+ TRL KLD+ + Y A+ILA AGL RL L R Sbjct: 141 VGTGSVRRVAQMKRRYPLLVIKDVRGNIDTRLQKLDSPDLPYTALILASAGLLRLSLHDR 200 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 I + L P IS PAVGQG +G E R D++ + +++ L + V AERA+ LEGGC Sbjct: 201 ITSYLSPPISYPAVGQGCLGAEFRSADTKVKAMVSRLEVWQDGWAVRAERALLWVLEGGC 260 Query: 243 QVPIGSYAELIDGEIWLRAL--VGAPDGSQIIRGERRGAPQDAE---QMGISLAEELLNN 297 P+G ++ I +L + +PDGS+ I E G E ++G A LL Sbjct: 261 AFPVGIWSSWSGDNIASESLSVMTSPDGSEEITVETTGVVASVEEVLELGKQAARSLLEK 320 Query: 298 GAREILAEV 306 G R I+ ++ Sbjct: 321 GGRGIIVDL 329 >UniRef50_C4QMG7 Hydroxymethylbilane synthase (Porphobilinogen deaminase, putative) n=1 Tax=Schistosoma mansoni RepID=C4QMG7_SCHMA Length = 411 Score = 189 bits (480), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 113/267 (42%), Positives = 154/267 (57%), Gaps = 19/267 (7%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 NV+R+ +R+S LAL Q + L +P ++ E+V M T GD ILD L+K+G K LF Sbjct: 8 NVVRVGSRRSNLALLQTGMAVNLLQKQNPHILFEVVEMATVGDKILDVSLSKIGDKSLFT 67 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRD-AFVSNNY--DSLDALP 120 KELE ALL D+ VHS+KDVP P GL L + R P D ++ +Y L LP Sbjct: 68 KELENALLSGEVDLVVHSLKDVPSTLPSGLVLGCVFARVSPEDVVLMAPHYRGRKLSDLP 127 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--------------NGEYDA 166 GS VGTS++RR L + P L S+RGN+ TRL+KLD + YDA Sbjct: 128 IGSTVGTSAVRRVATLTRKYPHLKFVSIRGNLNTRLAKLDTPPASKDNCCSGNPSPSYDA 187 Query: 167 IILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETAL 226 IILA AG++R+G RI L S AV QGA+ ECRL D+ +LL+ ++ AL Sbjct: 188 IILAKAGVERMGWSHRIDQVLTD--SFYAVSQGALACECRLVDNFIMDLLSHIHDESAAL 245 Query: 227 RVTAERAMNTRLEGGCQVPIGSYAELI 253 AER++ +L+GGC +PIG ++L+ Sbjct: 246 TTIAERSLMRQLDGGCSIPIGVRSDLV 272 >UniRef50_D1BFI8 Hydroxymethylbilane synthase n=4 Tax=Actinomycetales RepID=D1BFI8_SANKS Length = 312 Score = 189 bits (480), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 128/311 (41%), Positives = 175/311 (56%), Gaps = 18/311 (5%) Query: 6 LRIATRQSPLALWQAHYVKDKL--MASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 LRI TR S LAL Q V D L + P VE+VP+ T GDV+ + L+++GG G+FV Sbjct: 7 LRIGTRSSLLALTQTGTVADDLRRLTGRP---VEIVPVTTDGDVLTGS-LSQMGGTGVFV 62 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 L ALL++R D+AVHS+KD+P GL VT R+DPRDA S L LP G+ Sbjct: 63 TALRAALLDDRCDVAVHSLKDLPTAGVLGLQHVTPV-RQDPRDALCSRAGHRLADLPHGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--DNGEYDAIILAVAGLKRLGLES 181 VGT S RR QL RPDL + +RGN+ TRL ++ + G+ DA++LA AGL R+G E Sbjct: 122 RVGTGSPRRAAQLRLVRPDLDVVDIRGNIDTRLGRVHPETGDLDAVVLAAAGLNRIGREH 181 Query: 182 RIRAALPPEISLPAVGQGAVGIECRL----DDSRTRELLAALNHHETALRVTAERAMNTR 237 I + PA GQGA+ +E R +D L+ T+L V AERA+ R Sbjct: 182 AITELISVTDMAPAPGQGALAVETRSSLLEEDPVVARAFDQLDDPATSLSVLAERALLAR 241 Query: 238 LEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD-----AEQMGISLAE 292 LE GC P+G++A + DG + L A+V PDGS+ +R + D A +G ++A+ Sbjct: 242 LEAGCAAPVGTHATVSDGLLTLHAVVARPDGSEQLRHNQSTEVADTSTAEAVALGEAVAD 301 Query: 293 ELLNNGAREIL 303 L GA + Sbjct: 302 HFLALGAASFI 312 >UniRef50_Q4T5L1 Chromosome undetermined SCAF9206, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4T5L1_TETNG Length = 385 Score = 189 bits (479), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 139/377 (36%), Positives = 189/377 (50%), Gaps = 85/377 (22%) Query: 13 SPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLE 72 S LA Q V +KL +P + +E+V M T GD ILDT L+K+G K LF KELE AL Sbjct: 1 SQLARIQTDSVAEKLKELYPDVHLEIVAMSTTGDKILDTALSKIGEKSLFTKELENALER 60 Query: 73 NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDSLDALPAGSIVGTSS 129 N D+ VHS+KD+P P G + + +RE+P DA V N +LDALPA S++GTSS Sbjct: 61 NEVDLVVHSLKDLPTSLPPGFTIGAVLKRENPHDAVVLHPKNAGKTLDALPAHSVIGTSS 120 Query: 130 LRRQCQLAERRPDLII------------------------RSLRGNVGTRLSKLDNGE-Y 164 LRR QL +R P L RS RGN+ TRL KLD E + Sbjct: 121 LRRAAQLKKRFPHLDFKDIVSSERCFLPVQPGHRCFFLSSRSQRGNLNTRLKKLDEKEDF 180 Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224 AIILA AGL+R+G ++RI L PE + AVGQGA+ +E R D+ E+++ L+ +T Sbjct: 181 AAIILAAAGLRRMGWDNRISQILEPEDCMYAVGQGALAVEVRAKDADILEMVSVLHDPDT 240 Query: 225 ALRVTAERAMNTRL----------------------------EGGCQVPIGSYAELIDGE 256 LR AERA L EGGC VP+ + ++ D + Sbjct: 241 VLRCIAERAFLKHLVQHTHTHTHTHTHTRSLAVAHWNLFCLQEGGCSVPVAVHTKVKDSQ 300 Query: 257 IWLRALVGAPDGSQIIRGERR---GAPQD--------------------------AEQMG 287 ++L V + DGS ++ + AP D AE++G Sbjct: 301 LYLTGAVYSLDGSDSLKETMQTSVAAPADGSPDEVDECARVGVTANKIPGEAQDRAERLG 360 Query: 288 ISLAEELLNNGAREILA 304 + LA+ LL+ GA+EIL Sbjct: 361 VDLAKLLLSKGAKEILT 377 >UniRef50_UPI00006CBE06 porphobilinogen deaminase family protein n=1 Tax=Tetrahymena thermophila RepID=UPI00006CBE06 Length = 362 Score = 188 bits (477), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 126/332 (37%), Positives = 178/332 (53%), Gaps = 32/332 (9%) Query: 6 LRIATRQSPLALWQAHYVKDKLMA-SHPGLV---VELVPM-------------------- 41 +IA+R S LAL Q + V D L+ GL E+VP+ Sbjct: 21 FKIASRSSQLALSQTYEVIDLLVGVKELGLTKENFEVVPISNAPGKNCTLKFKINITNKQ 80 Query: 42 -VTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICE 100 +GD L PL +GG G+F K +EV LL DIAVHS+KD+P + L + + Sbjct: 81 FTNKGDQNLKDPLYVMGGVGVFTKIVEVELLNKNGDIAVHSLKDLPTIIDERLFIGAVPP 140 Query: 101 REDPRDAFVSNNYDS---LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLS 157 + D + N L LP GS++GTSSLRR L R P L ++RGN+ TRL+ Sbjct: 141 LKPRGDVVIFNEKHKGKELKDLPEGSVIGTSSLRRITNLKNRYPHLKYENIRGNLNTRLT 200 Query: 158 KLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLA 217 KL+NG+YDAIILA AG+ RLG ++ L E L A GQGA+G++CR DD LL+ Sbjct: 201 KLENGQYDAIILAEAGVFRLGWIEKVGQFLKQEDFLYAPGQGALGVQCRADDKEAIALLS 260 Query: 218 ALNHHETALRVTAERAMNTRLEG---GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRG 274 +N E +RV AER +LEG GC++PI ++E+ID + L V + + + IR Sbjct: 261 YINQKEPRIRVDAERQFLNKLEGVILGCKLPIAVHSEIIDQTLRLTGQVWSLEADKTIRE 320 Query: 275 ERRGAPQDAEQMGISLAEELLNNGAREILAEV 306 G D + +G+ L+E++ GA EIL ++ Sbjct: 321 VIEGHISD-QDLGLKLSEKMKQAGAGEILEKI 351 >UniRef50_B8MVK7 Porphobilinogen deaminase, putative n=1 Tax=Talaromyces stipitatus ATCC 10500 RepID=B8MVK7_TALSN Length = 413 Score = 187 bits (475), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 125/338 (36%), Positives = 172/338 (50%), Gaps = 40/338 (11%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVT------RGDVILDTPLAKVG 57 +R+ +R S +AL Q V L +H G P+ T R LAK Sbjct: 72 KAVRVGSRNSKMALIQTSSVAAALYKAHHGFFT--FPVSTHSVQGDRDKTSAFRDLAKAH 129 Query: 58 G---------KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAF 108 G K L+ E+E LL D+ VHS+KDVP P G + R DP DA Sbjct: 130 GNKQTAADTAKSLWTLEIEARLLAGDIDLIVHSLKDVPTTLPDGCEIGAFPHRNDPTDAL 189 Query: 109 VSNN---YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGE 163 + Y SL+ LPAGS+VGT S+RR QL P LII+ RGNV TR++KLD + Sbjct: 190 LVKAGLPYKSLEELPAGSVVGTCSVRRTAQLRHYCPHLIIQECRGNVDTRVAKLDANDSP 249 Query: 164 YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHE 223 Y AI++A AG+ RL LE RI L AVGQGA+GIE R +D + REL+A ++H Sbjct: 250 YTAIVVAAAGIVRLNLEHRITQRLSGPAYTYAVGQGALGIEIRKEDQKARELVACIDHWP 309 Query: 224 TALRVTAERAMNTRLEGGCQVPIGSYAELI---------------DGEIWLRALVGAPDG 268 T +R AERA+ L+GGC PIG ++ + +G ++L + PDG Sbjct: 310 TRVRCLAERALLRFLQGGCSAPIGVHSAFVRTPAKGEPNVNDNHYEGTLYLTGTLLHPDG 369 Query: 269 SQIIRGERRG---APQDAEQMGISLAEELLNNGAREIL 303 IR +G D+E +G S+ +++L+ G +IL Sbjct: 370 GMEIRAHEKGQVKCTADSETIGKSVGKKILDLGGAQIL 407 >UniRef50_B9XN63 Porphobilinogen deaminase n=1 Tax=bacterium Ellin514 RepID=B9XN63_9BACT Length = 332 Score = 187 bits (475), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 121/290 (41%), Positives = 160/290 (55%), Gaps = 36/290 (12%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG---KGLFVK 64 IATR S LAL QA+ V + ++ P L +EL + T GD + LAK G KGLF K Sbjct: 11 IATRGSALALAQANAVLSQCRSAFPKLDIELKIIKTTGDKLQKASLAKEGESLPKGLFTK 70 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA------ 118 ELEVALL ADIAVHS+KD+P E P GL L + +R D RD V + + L + Sbjct: 71 ELEVALLNGDADIAVHSLKDLPTELPTGLILGAVSKRADVRDVLVYRDAEYLRSQPGKSN 130 Query: 119 ------------LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG-EYD 165 P G+ V TSS RR+ QL +R DL + +RGNV TRL KL N E D Sbjct: 131 RRGFTPKLAIKDFPPGATVATSSTRRKAQLLAQRGDLNVVEIRGNVATRLEKLANQPELD 190 Query: 166 AIILAVAGLKRLGL--------------ESRIRAALPPEISLPAVGQGAVGIECRLDDSR 211 A +LA AGL+RL E + L ++ LP VGQ A+G+E R +D+R Sbjct: 191 ATVLAAAGLERLNFKITAEGKLAGEGIPEGLLATILDFDVMLPCVGQAALGMEIRENDAR 250 Query: 212 TRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRA 261 +E+ LNH ET V AER+ + + GGCQ P+ +YAE+ ++ +RA Sbjct: 251 IQEICDRLNHPETHACVLAERSFLSGMGGGCQSPVAAYAEIAGDQLQMRA 300 >UniRef50_C4ZFT9 Porphobilinogen deaminase n=1 Tax=Eubacterium rectale ATCC 33656 RepID=C4ZFT9_EUBR3 Length = 338 Score = 186 bits (472), Expect = 8e-46, Method: Compositional matrix adjust. Identities = 113/308 (36%), Positives = 161/308 (52%), Gaps = 39/308 (12%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67 I TR S LAL Q YV DKL ++P + V + T GD+ L K+G KG+FVKE+E Sbjct: 5 IGTRGSKLALVQTDYVIDKLKRAYPDDDFKAVIIKTTGDLEQKKALDKIGSKGIFVKEIE 64 Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127 LL + +AVHSMKD+P E GL +REDPRD V N SLD LP G+++GT Sbjct: 65 DELLSGKIHMAVHSMKDMPDEPAAGLTFAKAWKREDPRDVLVLKNAASLDELPHGAVIGT 124 Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE------------------------ 163 S RR+ QL + RPDL + +RGN+ TRL KL +GE Sbjct: 125 GSKRRKYQLLKLRPDLKVVGIRGNIDTRLRKLYDGEIIYEEVADNTVNNNEIANEKKNKY 184 Query: 164 ----YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAAL 219 D I+LA AG+KR+G +S I + +PA QG + +E R D+++ L AL Sbjct: 185 SEYRLDGIVLAAAGIKRIGRDSEITQYFSEDDMIPAPAQGTLALELRADNAKLMAKLDAL 244 Query: 220 NHHETALRVTAERAMNTRLEGGCQVPIGSYAELI-----------DGEIWLRALVGAPDG 268 + +T L ER ++ G C +P+ +Y +++ + + L A+ G+ DG Sbjct: 245 SDEKTNLCAGIEREFLKQIGGNCHLPVAAYCDIVSEKDRGNDSNKNNRLKLLAMFGSEDG 304 Query: 269 SQIIRGER 276 Q+ R E+ Sbjct: 305 KQLARTEQ 312 >UniRef50_Q0ATQ1 Porphobilinogen deaminase n=3 Tax=Alphaproteobacteria RepID=Q0ATQ1_MARMM Length = 321 Score = 186 bits (471), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 132/298 (44%), Positives = 168/298 (56%), Gaps = 16/298 (5%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVE-------LVPMVTRGDVILDTPLAKVGG 58 L IATR+SPLAL QA V+ KL A+ GL E ++ +V+ GD I D L + GG Sbjct: 8 LAIATRRSPLALVQARDVQAKL-AAQCGLSGEDAERCFPILGLVSTGDRIQDRTLIEAGG 66 Query: 59 KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS-LD 117 KGLF KE++ A L+ RA AVHSMKDVP P G+ L + EREDPRD ++ + ++ L Sbjct: 67 KGLFTKEIDEAQLDGRAAFAVHSMKDVPTVLPDGIVLGALLEREDPRDMLIARDGETRLA 126 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177 LP G +GT+SLRRQ QL +RPDL + LRGNV TRL KL +G A LA AGL RL Sbjct: 127 DLPEGVTIGTASLRRQAQLLHKRPDLHVVPLRGNVDTRLGKLADGGIHATFLARAGLNRL 186 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 G +R L + LPA QGAVG+ R D +A L+H +T L V AERA Sbjct: 187 GRAEALRDPLEADEMLPAAAQGAVGVAIRDGDEEAASYVAGLHHRDTELAVLAERAFLFE 246 Query: 238 LEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-----GAPQDAEQMGISL 290 L+G C+ PI ++ + + L PDG Q R + R P A Q G L Sbjct: 247 LDGSCRTPIAAHVNKVSMDFIGEVLT--PDGQQSWRRQIRFDMTHATPDSARQAGQDL 302 >UniRef50_Q4PFH9 Putative uncharacterized protein n=1 Tax=Ustilago maydis RepID=Q4PFH9_USTMA Length = 770 Score = 186 bits (471), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 117/292 (40%), Positives = 155/292 (53%), Gaps = 39/292 (13%) Query: 38 LVPMVTRGDVILDTPLAKVGGKG--LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGL 95 + M T GD L +PL +GG+G ++ KELEVAL + D VH +KDVP PQGL L Sbjct: 253 ITSMSTAGDQNLRSPLYVIGGEGKAIWTKELEVALEQGAVDAIVHCLKDVPTALPQGLEL 312 Query: 96 VTICEREDPRDAFVSNN---YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNV 152 + EREDPRDA V Y LD LP GS++GTSS+RR QL R P L+ +RGN+ Sbjct: 313 AAVLEREDPRDALVVKAGLPYKVLDELPVGSVIGTSSVRRVAQLRRRYPHLVFSDVRGNI 372 Query: 153 GTRLSKLD--NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLD-- 208 TRL+KLD NG Y A+ILA AGL RL + +RI A L + L +VGQG++ IE R Sbjct: 373 NTRLAKLDAPNGPYTALILAAAGLVRLNMHARITAFLSSPVLLHSVGQGSLAIEVRTPPE 432 Query: 209 --------DSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLR 260 D+R REL+ ++ R AER++ LEGGC +P+G Sbjct: 433 GADPTTNRDARIRELIRSIGDWRATFRAEAERSLLKELEGGCSIPVGVETRF-------- 484 Query: 261 ALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYNGDAP 312 D + G+R A I+L ++ + G AE+ NG P Sbjct: 485 ------DDHDQVEGQRSEA--------IALVDDFVTQGNAGAKAELPNGGMP 522 >UniRef50_C9M5W1 Hydroxymethylbilane synthase n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M5W1_9BACT Length = 714 Score = 186 bits (471), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 121/298 (40%), Positives = 165/298 (55%), Gaps = 9/298 (3%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 L LR+A+R+S LA+ Q+ V ++L + G VE++P TRGD + D L GGKGL Sbjct: 422 LGRPLRLASRESELAMAQSRLVAERLHEAT-GFDVEIIPFRTRGDAVADRRLESAGGKGL 480 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKELE A+L +AD+AVHS+KD+P P GL + +R+ D V L P Sbjct: 481 FVKELERAILSGQADLAVHSLKDMPSSCPDGLAFAALMDRQTAFDCLVLR--PGLTGRPV 538 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 +GTSS RR Q D LRGN+ TRLSKLD GE+DA+ILA AGL+RLGL+ Sbjct: 539 --RIGTSSARRIAQGRALFSDAQFVPLRGNLRTRLSKLDGGEFDALILAEAGLRRLGLQE 596 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 R+ + +P+ GQG + ++C D +L++ L+ AERA RL GG Sbjct: 597 RVSRVFSADQMIPSAGQGTLAVQCPFDGP-VFDLVSQLDEPAVRTCCLAERAFIDRLNGG 655 Query: 242 CQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 C P G+YA +DGE I + L PDG + + G+ G D + LA+ L G Sbjct: 656 CTAPHGAYAR-VDGETIEMIGLYVRPDG-KTLSGKISGPAADGPSLAAELADRLKRRG 711 >UniRef50_C5EV71 Pyruvate ferredoxin/flavodoxin oxidoreductase n=3 Tax=Clostridiales RepID=C5EV71_9FIRM Length = 301 Score = 185 bits (470), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 116/269 (43%), Positives = 153/269 (56%), Gaps = 15/269 (5%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + N++RI TR+S LAL Q H + D L + P + VELV T GD ILD PL + GGKG+ Sbjct: 1 MSNIIRIGTRKSALALIQTHLIADGLKRAWPDIEVELVTKETLGDKILDKPLQEFGGKGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FV E E A+ E D+AVHS KD+P+E +GL + + R DPRD V+ D Sbjct: 61 FVSEFEQAMKEGAIDLAVHSAKDLPMELGEGLVIAAVSGRGDPRDVLVTMKGSPKDR--E 118 Query: 122 GSIVGTSSLRRQCQLAERR-------PDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174 ++GTSS RRQ + E R L +LRGNV TRL KL+ G YD IILA AGL Sbjct: 119 HIVIGTSSPRRQLEAVEYRGQLWPGAASLTCATLRGNVHTRLRKLEEGLYDGIILAAAGL 178 Query: 175 KRLGL---ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231 +RL L S L P + +PA GQG + +E R + S L A++ E L +T E Sbjct: 179 ERLDLLGNPSYDFKYLDPTVFIPAGGQGIMAVEAR-EGSDAARLCQAIDSREGRLCLTLE 237 Query: 232 RAMNTRLEGGCQVPIGSYAELIDG--EIW 258 R + L+ GC PIG Y+ ++DG E+W Sbjct: 238 RMVLKLLDAGCHEPIGIYSNIMDGKMEVW 266 >UniRef50_Q93A65 Porphobilinogen deaminase n=1 Tax=uncultured bacterium RepID=Q93A65_9BACT Length = 299 Score = 185 bits (470), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 116/254 (45%), Positives = 156/254 (61%), Gaps = 13/254 (5%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +R+ATR S LALWQA +V +L+ G VELV + T+GD P A++ G+G F K Sbjct: 4 VRLATRGSRLALWQAEWVAKQLV--QQGAEVELVVVETQGDRE-KRPFAQMQGQGFFTKA 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD----ALP- 120 ++ A+LE RAD AVHS KD+P P GL + + REDPR+ + ++D LP Sbjct: 61 VQEAVLEGRADFAVHSYKDLPSARPAGLEIAAVPPREDPRELLLVR-LQAVDQVAPGLPL 119 Query: 121 -AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 AG+ VG+S+ RRQ QLA RPDL + LRGNV TR+ KL GEYDA++LA AG++RLGL Sbjct: 120 RAGARVGSSAARRQAQLAHLRPDLSLLELRGNVLTRVEKLRQGEYDAVLLAYAGVRRLGL 179 Query: 180 E--SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 + LPP + +PA QGA+ +ECR DD R R LL L+ +R M R Sbjct: 180 DLSPFHWQVLPPTLLVPAPAQGALALECRQDDKRLRPLLEPLDDPSAGVRCGGAGLM-AR 238 Query: 238 LEGGCQVPIGSYAE 251 L GGCQ+ +G+ A+ Sbjct: 239 LAGGCQLALGALAQ 252 >UniRef50_A8PWJ5 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8PWJ5_MALGO Length = 530 Score = 185 bits (469), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 122/322 (37%), Positives = 171/322 (53%), Gaps = 56/322 (17%) Query: 41 MVTRGDVILDTPLAKVGGKG--LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTI 98 M T GD L +PL +GG+G ++ KELEVAL+ D VHS+KDVP P G+ L I Sbjct: 161 MATLGDQNLKSPLYVIGGEGRAIWTKELEVALMAGGVDAIVHSLKDVPTTMPDGVELAAI 220 Query: 99 CEREDPRDAFVSNN---YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTR 155 EREDPRDA V Y SL +P GS++GTSS+RR L P L+ +RGN+ TR Sbjct: 221 LEREDPRDALVVKENLPYKSLQEMPQGSVIGTSSVRRVSLLRRAYPHLMFSDVRGNINTR 280 Query: 156 LSKLD--NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLD----- 208 L+KLD +G Y A++LA AGLKR+ LE RI A + + L AVGQG++ IE R Sbjct: 281 LAKLDAADGPYTALVLAAAGLKRMDLEHRITAYVSEPVMLHAVGQGSLAIEVRTPRGESA 340 Query: 209 --DSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGE---------- 256 D R R ++ ++++ R AERA+ R+EGGC +P+G D Sbjct: 341 ERDERIRRMIRSISNWRATWRCVAERALMHRMEGGCSIPLGVSTRFEDHADIEGLLNERN 400 Query: 257 ----------------------------IWLRALVGAPDGSQIIRGERRG---APQDAEQ 285 + + A++ + DG+++ + + +DAEQ Sbjct: 401 ETPSEMASAGISRPDIRIAHEPPPQGSFLTMAAVIVSLDGTRMCKHSHTQLCRSEKDAEQ 460 Query: 286 MGISLAEELLNN-GAREILAEV 306 +GI +AEEL ++ AR ILAEV Sbjct: 461 LGILVAEELEHHQNARAILAEV 482 >UniRef50_Q6L2G8 Probable porphobilinogen deaminase n=1 Tax=Picrophilus torridus RepID=HEM3_PICTO Length = 282 Score = 185 bits (469), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 105/255 (41%), Positives = 151/255 (59%), Gaps = 8/255 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LA+ QA VKD+L G+ E+ ++GD+ LD+PL +GG G+FV + Sbjct: 3 IRIGTRSSKLAMIQAMMVKDRL--DSLGIETEVKGFTSKGDINLDSPLYSIGGTGVFVDD 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L +L+N DIAVHS KD+P L + + +R+DPRD +S + SL+ L A S++ Sbjct: 61 LNRMILKNEIDIAVHSAKDIPSFIDDSLEISAVLKRDDPRDVLISQH--SLNDLEASSVI 118 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR +L R D++I+ LRGN+ TRL KLDNG+YD II+A A R+ + R Sbjct: 119 GTSSLRRIKELKTLRNDILIKDLRGNIDTRLKKLDNGDYDGIIMAKAAYDRMRINRR-HF 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L + +PA QG + I + DS ++L +N ET + AER + + L GC P Sbjct: 178 ILNYDDFVPAPNQGIIAIISK-KDSEINDVLKKINDDETYNDMKAERLILSGLNLGCSKP 236 Query: 246 IGSYAELIDGEIWLR 260 +G YA I++R Sbjct: 237 VGIYAH--KNRIFMR 249 >UniRef50_A2BFN7 Hydroxymethylbilane synthase (Fragment) n=6 Tax=Coelomata RepID=A2BFN7_DANRE Length = 247 Score = 185 bits (469), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 113/227 (49%), Positives = 144/227 (63%), Gaps = 4/227 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 V+R+ TR+S LA Q V L +P + +E+V M T GD ILDT L+K+G K LF K Sbjct: 21 VIRMGTRKSQLARIQTDSVAGTLKQLYPDVHLEIVAMSTIGDKILDTALSKIGEKSLFTK 80 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDSLDALPA 121 ELE AL N DI VHS+KD+P P G + I ERE+P DA V N +LD+LP Sbjct: 81 ELENALERNEVDIVVHSLKDLPTSLPPGFTIGAILERENPHDAVVLHPKNAGLTLDSLPE 140 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD-NGEYDAIILAVAGLKRLGLE 180 S++GTSSLRR QL +R P L ++RGN+ TRL KLD +Y AIILA AGLKR+G E Sbjct: 141 KSVIGTSSLRRAAQLKKRFPQLEFENIRGNLNTRLKKLDEKDDYAAIILAAAGLKRMGWE 200 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALR 227 SRI L PE + AVGQGA+ +E R D E+++ L+H +T LR Sbjct: 201 SRISQVLGPEDCMYAVGQGALAVEVRAQDKDILEMVSVLHHPDTVLR 247 >UniRef50_O29026 Probable porphobilinogen deaminase n=1 Tax=Archaeoglobus fulgidus RepID=HEM3_ARCFU Length = 289 Score = 184 bits (467), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 106/247 (42%), Positives = 148/247 (59%), Gaps = 7/247 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L + TR S LAL Q + V ++L + VE+ + T GD++ D PL + G G FV+ Sbjct: 3 LIVGTRGSKLALAQTNKVAERLKERYE---VEIRIVKTAGDIMKDKPLYEFKGMGAFVRA 59 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L+ AL E + D+AVHS KDVP + +G + + ER+ P D +S + +L+ L G++V Sbjct: 60 LDTALAEGKVDVAVHSFKDVPSQRVEGTVVAAVIERDSPCDVLISRDGSTLEELDEGAVV 119 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR+ QL+ R DL +LRGN+ TRL KL G YDAI++A AGLKRLGL+ + Sbjct: 120 GTSSLRRRAQLSRLRGDLRFENLRGNLDTRLRKLREGNYDAIVVAEAGLKRLGLDREVEY 179 Query: 186 A-LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 PPE+ +P QG + I R + +L+A LN +T L ERA+ L GC V Sbjct: 180 QPFPPEVIVPPANQGIIAIATRKGEE---DLVAFLNDEKTWLEAMVERAVIKELGVGCAV 236 Query: 245 PIGSYAE 251 P+G YAE Sbjct: 237 PVGVYAE 243 >UniRef50_B2W5W6 Porphobilinogen deaminase n=2 Tax=Pleosporineae RepID=B2W5W6_PYRTR Length = 399 Score = 184 bits (467), Expect = 4e-45, Method: Compositional matrix adjust. Identities = 131/347 (37%), Positives = 182/347 (52%), Gaps = 47/347 (13%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG----GKGL 61 + I TR S LA QA V+ L ++P + P++ +GD TPL ++ K L Sbjct: 31 VNIGTRNSVLAQIQARAVERSLKDAYPERTYNICPVIVQGDRDKITPLQQLSQGENAKSL 90 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN----NYDSLD 117 + ELE L DI VH +KD+P + P L L I EREDPRDA + + +L Sbjct: 91 WTGELESMLESGDLDIIVHCLKDMPTQLPDHLELGAILEREDPRDALLVSPRLPKETTLA 150 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLK 175 LP G+ +GTSS+RR L + P L LRGNVGTRL+KLD + Y AIILA AGLK Sbjct: 151 TLPQGATIGTSSVRRAATLRKLYPHLKFADLRGNVGTRLAKLDAEDSPYSAIILAAAGLK 210 Query: 176 RLGLESRIRAALPPEIS--LPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERA 233 R+GL++RI L L AVGQGA+GIE R +D +EL++ + T +AERA Sbjct: 211 RMGLDNRITQYLSSTSGGMLHAVGQGALGIEIRKNDEAMKELMSKIRCERTTRACSAERA 270 Query: 234 MNTRLEGGCQVPIG------------------------------SYAELIDGEIWLRALV 263 + LEGGC VPIG ++ D E+ +RA+V Sbjct: 271 LLRTLEGGCSVPIGVETSWKGGKGLSVGPQPAKDYDKHGNAVEEDEPDVDDQELVMRAMV 330 Query: 264 GAPDGSQIIRGER----RGAPQDAEQMGISLAEELLNNGAREILAEV 306 + DG + + E R A ++AE+MG +A+ L+ GA +IL ++ Sbjct: 331 VSVDGKESVEYEATRKVRNA-EEAEEMGREVAKILIEKGADKILEKI 376 >UniRef50_A9HK97 Porphobilinogen deaminase n=12 Tax=Acetobacteraceae RepID=A9HK97_GLUDA Length = 367 Score = 183 bits (464), Expect = 8e-45, Method: Compositional matrix adjust. Identities = 134/320 (41%), Positives = 173/320 (54%), Gaps = 21/320 (6%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGL----VVELVPMVTRGDVILDTPLAKVGGKGL 61 LR+ TR SPLAL Q L P L + + T GD + + LA++GGKGL Sbjct: 47 LRVGTRASPLALVQTRAFLTMLTRFCPVLRDMGAFQEHQINTTGDQVQNRRLAEIGGKGL 106 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV-----------S 110 F KE+ AL + R D AVHS+KD+ P GL L RED RDA + + Sbjct: 107 FAKEIHDALSDGRIDFAVHSLKDLETTLPPGLVLACTLRREDARDALILGPGAGGRHDAA 166 Query: 111 NNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILA 170 + D ALP ++VG +S+RRQ Q+ RPDL LRGNV TRL KL + DA +LA Sbjct: 167 DAADPYAALPRNALVGCASVRRQAQMLHVRPDLRFGLLRGNVQTRLDKLAARQCDATLLA 226 Query: 171 VAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTA 230 +AGL+RLG+E R L PEI +PA GQG VG+ R D RELLAA+ +E TA Sbjct: 227 LAGLRRLGMEDRADIVLDPEIMVPAAGQGIVGVTVRESDVELRELLAAIEDYEARAVATA 286 Query: 231 ERAMNTRLEGGCQVPIGSYAELIDG------EIWLRALVGAPDGSQIIRGERRGAPQDAE 284 ERA+ L+G C+ PIG YA L+ G + L LV DGS ++R G DAE Sbjct: 287 ERALLAELDGSCRTPIGGYARLVPGLAGAEASLRLTGLVAREDGSFLLRRTVTGLRADAE 346 Query: 285 QMGISLAEELLNNGAREILA 304 +MG L L + ++ A Sbjct: 347 EMGRELGRSLRMDSPSDVFA 366 >UniRef50_C1XV35 Porphobilinogen deaminase n=2 Tax=Meiothermus RepID=C1XV35_9DEIN Length = 304 Score = 182 bits (461), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 118/266 (44%), Positives = 165/266 (62%), Gaps = 10/266 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RIATR S LA WQA +V +L G+ LV + T+GD +++ G+G F K Sbjct: 4 VRIATRGSRLARWQAEWVAAQL--QDQGIASTLVIVETQGDRE-RVAFSQMQGQGFFTKA 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV--SNNYDS-LDALP-- 120 ++ A+ E RAD+AVHS+KD+P GL L I REDPR+A + + +D+ ALP Sbjct: 61 VQDAVREGRADLAVHSLKDLPSAPTPGLVLAAIPIREDPREALLVLPSAWDAQAPALPLA 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VG+S++RRQ QLA+ RPDL + LRGNV TR+ KL +G Y+AI+LA AGLKRLGL+ Sbjct: 121 PGARVGSSAVRRQAQLAQLRPDLKLLELRGNVPTRVEKLQSGGYEAILLAWAGLKRLGLD 180 Query: 181 SRIRAA--LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 A L P +PA GQGA+ +ECR +D++ R +L L+ L V ER + RL Sbjct: 181 LGGLAVRLLEPREFVPAPGQGALALECREEDTQLRGVLQGLDDPTARLTVGIERGLMARL 240 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVG 264 +GGCQ+ +G+ A+ + G L A G Sbjct: 241 QGGCQLALGASAQRVQGGWQLLAWYG 266 >UniRef50_A4QB59 Porphobilinogen deaminase n=15 Tax=Corynebacterium RepID=HEM3_CORGB Length = 302 Score = 181 bits (459), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 120/305 (39%), Positives = 173/305 (56%), Gaps = 10/305 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 L+I TR S LA QA ++D+L + G EL + T GDV + +P+ ++G G+F + Sbjct: 2 TLKIGTRGSKLATTQAGTIRDQL--KYFGRDAELHIVTTPGDVNM-SPVERIG-VGVFTQ 57 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L L D+AVHSMKD+P LV + R D R+A ++ + +L LP G+ Sbjct: 58 ALRDVLHAGECDVAVHSMKDLPTAADPRFHLV-VPTRADSREALIARDGLTLAELPEGAK 116 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGTS+ RR QL RPDL I LRGN+ TR+ K+ +GE DA++LA AGL R+G++ R Sbjct: 117 VGTSAPRRISQLKAIRPDLEILPLRGNIDTRMGKVTSGELDAVMLAYAGLTRVGMQDRAT 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 +I +PA QGA+ IECR DD+ T L L H +T + AER + RLE GC Sbjct: 177 EVFDADIIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVLNRLEAGCTA 236 Query: 245 PIGSYAELIDG----EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 P+ ++A L DG + L A V A DGS + G E++G +A++L++ GA Sbjct: 237 PVAAHATL-DGYSGDTMTLTAGVYALDGSDQLVFSAEGDGARPEELGELVAQQLIDAGAA 295 Query: 301 EILAE 305 +L + Sbjct: 296 NLLGD 300 >UniRef50_C6V4N6 Porphobilinogen deaminase n=2 Tax=Neorickettsia RepID=C6V4N6_NEORI Length = 286 Score = 181 bits (458), Expect = 4e-44, Method: Compositional matrix adjust. Identities = 113/290 (38%), Positives = 164/290 (56%), Gaps = 9/290 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L++ R S LAL QA V+ L ++LV + T GD++ D PL +VGGK LF+KE Sbjct: 4 LKVGARCSTLALAQARLVERALAPYCER--IDLVGVRTSGDILSDIPLTEVGGKALFLKE 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE LL DIAVHSMKDVP + L +V + +R P D FVS Y ++ +LP+G+++ Sbjct: 62 LEEKLLTGEIDIAVHSMKDVPAFYHDDLEVVPVLKRAIPNDVFVSFRYPNMLSLPSGAVI 121 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT + RR QL +R + LRGN+ TR+ K N D IILA GL+RLGL I Sbjct: 122 GTCAPRRVVQLNQR---FRVIPLRGNIATRVEKAKN--LDGIILAFCGLERLGLCKMISE 176 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 + ++ LP V QGA+ +E R D REL+ ++ ET + TAERA + G C+ Sbjct: 177 VIHEDVMLPGVAQGALCVEFRKKDHFLRELILNISDRETIICTTAERAFLEEINGDCKTA 236 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295 +G+ A + + ++ ++G + R G+ +A+Q+G S A LL Sbjct: 237 LGALAVVKNNTLYFTGMLGKDNRPCYFRTS--GSCLNAKQIGRSAALALL 284 >UniRef50_A8SQW4 Putative uncharacterized protein n=1 Tax=Coprococcus eutactus ATCC 27759 RepID=A8SQW4_9FIRM Length = 350 Score = 180 bits (456), Expect = 6e-44, Method: Compositional matrix adjust. Identities = 109/265 (41%), Positives = 150/265 (56%), Gaps = 20/265 (7%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +++ TR S LAL Q V L P + ++V M TRGD L + GGK +FV+ Sbjct: 41 TVKVGTRGSKLALAQTELVIKALNERFPQIDFQMVTMSTRGDRDTSRALLEFGGKAVFVE 100 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E E A+L+ DIAVHS KD+P+E +GL + R P+D F+ + S D + + Sbjct: 101 EFEEAILKGDIDIAVHSAKDMPMEIMEGLTISGTLPRACPQDVFIYKSGRSFDRNDS-FV 159 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL----- 179 VGTSSLRRQ Q+ + P+ + ++LRGNVGTR+ KL++GEYDAIILA AGL+RLG+ Sbjct: 160 VGTSSLRRQYQIRDMYPNAVCKNLRGNVGTRIQKLEDGEYDAIILAAAGLERLGVIEDKG 219 Query: 180 ------------ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALR 227 E R L E LPA QG + IE R +++ A+N E + Sbjct: 220 NDSTECFEVHKDELTFR-YLSTESMLPAACQGIIAIETRT-SGEAYDMVRAINDTEAYTQ 277 Query: 228 VTAERAMNTRLEGGCQVPIGSYAEL 252 +T ERA+ +RL GC PIG Y+EL Sbjct: 278 LTCERAVLSRLNAGCHEPIGVYSEL 302 >UniRef50_C7M2H5 Porphobilinogen deaminase n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7M2H5_ACIFD Length = 291 Score = 179 bits (455), Expect = 8e-44, Method: Compositional matrix adjust. Identities = 123/294 (41%), Positives = 169/294 (57%), Gaps = 14/294 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RIATR+S LA WQA V ++L ELV + T GD + LA++GG+G+FVKE Sbjct: 4 VRIATRRSALARWQASLVGERLGR------YELVEVHTAGDRDQASSLAEIGGQGVFVKE 57 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 ++ A++ ADIAVHS KD+P L L + ER D RDA V L+ L G+ V Sbjct: 58 VQAAVVRGEADIAVHSAKDLPTAAGPLL-LAAVLERADARDAIVGAR---LEELAIGARV 113 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTS+ RR QL RPDL + S+RGN+ TRL ++ GE DAI++AVA L+RLGLE Sbjct: 114 GTSAPRRAAQLRLLRPDLEVVSIRGNIATRLGRV--GELDAIVMAVAALERLGLEEPPWW 171 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 LP E+ P GQGA+ +EC D E L +L+ + + AERA+ GC +P Sbjct: 172 PLPEEVLCPQAGQGAIAVECAPDADGLIERLRSLDDDRSRREIEAERAVLAAFGTGCALP 231 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 +G+ A + LRA+ PDG++ + ER G D +G ++AE L GA Sbjct: 232 LGARAHADGSSLRLRAVAVDPDGTRQLEVEREGV--DPATLGATVAEVLRRLGA 283 >UniRef50_B3DZQ6 Porphobilinogen deaminase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DZQ6_METI4 Length = 298 Score = 179 bits (454), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 115/294 (39%), Positives = 166/294 (56%), Gaps = 3/294 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L I +R S LAL QA + D L +P L +++ + T GD + P+ + +G+F KE Sbjct: 4 LIIGSRGSRLALIQAQLIVDSLKKEYPLLDIQIRVIKTTGDHLEAQPIRDIDQRGIFTKE 63 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E LLE D+AVHS+KD+ VE L + I REDPRD ++S + +L AG+IV Sbjct: 64 IENKLLEGEIDLAVHSLKDLQVELHPRLVIAAIPPREDPRDCWISLQHPHPSSLQAGAIV 123 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-DNGEYDAIILAVAGLKRLGLE--SR 182 T S RR QL +RPDL I +RGNV +RL KL +N ++ +LA+AG+KRLG++ S Sbjct: 124 VTGSPRRANQLLRKRPDLRIVPVRGNVESRLRKLRENRQWQGTVLALAGIKRLGIDISSF 183 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 L + LPA GQGA+ ++ R++D T+ L+ LN TA VTAER L GGC Sbjct: 184 FCTPLSMDWMLPAPGQGALALQARIEDKHTQSLVKHLNDFSTACAVTAERVFLHELGGGC 243 Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 + +G+ AE+ + L + + G+ G AE +G LA+ L N Sbjct: 244 RTAVGARAEVEGSRLVLEGIWWPQQAIEPKEGKVVGEIHRAEDLGKKLADLLKN 297 >UniRef50_C5CB88 Porphobilinogen deaminase n=5 Tax=Actinomycetales RepID=HEM3_MICLC Length = 377 Score = 179 bits (454), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 122/304 (40%), Positives = 165/304 (54%), Gaps = 38/304 (12%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LRI TR S LA Q +V + L A GL ELV + T GDV + LA +GG G+F Sbjct: 4 LRIGTRGSALATTQTSHVAEALTARS-GLAHELVVIRTEGDVTTGS-LASLGGTGVFASA 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L A+L+ D AVHS+KD+P P+ L + + R D RDA + + +L LP G+ V Sbjct: 62 LRAAVLDGVVDAAVHSLKDLPAAQPETLEIAAVPARADLRDALCARDGLTLATLPEGARV 121 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN----------------GEYDAIIL 169 GT S RR QL RPDL + +RGNV TRL+++ G+ DA+IL Sbjct: 122 GTGSPRRVAQLKALRPDLELVDIRGNVQTRLARVPGLEQHDDHAPAAVGSPRGDLDAVIL 181 Query: 170 AVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDD---------------SRTRE 214 A AGL RLGL+ I + PE+ +PA GQGA+ +E R +D R Sbjct: 182 ACAGLDRLGLDHVITERIDPEVMVPAPGQGALAMEIRAEDESFLGRALLDPEAPVGRLHA 241 Query: 215 LLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGE-----IWLRALVGAPDGS 269 L ++ +T + VTAERA+ RLE GC PIG+ A + DGE I + A+V A DGS Sbjct: 242 ALELVDDRDTHVAVTAERALLRRLEAGCAAPIGAVARVGDGEAGAPRIEMTAMVAALDGS 301 Query: 270 QIIR 273 +++R Sbjct: 302 RVLR 305 >UniRef50_C7DH16 Porphobilinogen deaminase n=1 Tax=Candidatus Micrarchaeum acidiphilum ARMAN-2 RepID=C7DH16_9EURY Length = 301 Score = 179 bits (454), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 107/300 (35%), Positives = 172/300 (57%), Gaps = 7/300 (2%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M ++ + I TR S LA+ QA V++KL A P + +V + T + + D A+ K Sbjct: 1 MSESEITIGTRGSELAVAQAEIVRNKLAAIEPRISFRIVKIKTLNEKV-DRSKARTE-KD 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 ++ KE++ A+LE R DIAVHS+KD+ + + + + +R+DPRD F+ N + L Sbjct: 59 IYTKEIDEAILERRIDIAVHSLKDLKFNMDENMQIGAVPDRDDPRDVFIGNTETEFEHLG 118 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 ++VGTSS+RR+ QL P +I L GN+ TRLSKL++GE+ I++A AG+KRLG Sbjct: 119 TDALVGTSSIRRRVQLTRINPKPMISDLHGNIDTRLSKLNSGEFSGIVIAAAGVKRLGKA 178 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R++ ++ +PA+GQGA+ + D+S ELL +++ + + V E Sbjct: 179 VRMQYFDERDV-VPAIGQGAIAVTVHKDNSAAAELLKRIDNMKARVEVGEEIEFGKAFGT 237 Query: 241 GCQVPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GC +PIG+ A++++ G+I + V G +++GE P A G SLAE L+ GA Sbjct: 238 GCNLPIGANAKMLESGKIGIVGFVSDLAGKTLVKGETETGPGHA---GKSLAELLIKKGA 294 >UniRef50_D2RH82 Porphobilinogen deaminase n=2 Tax=Archaeoglobaceae RepID=D2RH82_ARCPR Length = 292 Score = 179 bits (453), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 100/244 (40%), Positives = 145/244 (59%), Gaps = 6/244 (2%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67 + TR S LAL Q V ++L G VE+ + + GD++ D PL + G G FV+ LE Sbjct: 7 VGTRGSKLALAQTSKVVERL--KEEGYSVEIRIIKSTGDIMKDKPLYEFKGSGAFVRALE 64 Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127 AL+ D+AVHS KD+P +G+ + + ER+ P DAF++ N +SL+ + +++GT Sbjct: 65 HALVRGEIDVAVHSYKDIPSNMLEGVTVSAVLERDSPYDAFIARNGESLEEIKPNAVIGT 124 Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAAL 187 SSLRR+ QL R DL +LRGNV TRL KL G YDAI+LA AG++RLGL + + L Sbjct: 125 SSLRRRAQLKLYRSDLRFENLRGNVDTRLRKLREGLYDAIVLAEAGIQRLGLNVKYQ-RL 183 Query: 188 PPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIG 247 P E +P QG + ++ R+ + +L+ +NH ET + ER + L GC +P G Sbjct: 184 PIERFVPPANQGIIAVQTRVGEE---DLVKFMNHEETWIEAEVERIVMKTLGVGCAIPAG 240 Query: 248 SYAE 251 YAE Sbjct: 241 IYAE 244 >UniRef50_B4D5X7 Porphobilinogen deaminase n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4D5X7_9BACT Length = 307 Score = 179 bits (453), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 114/276 (41%), Positives = 153/276 (55%), Gaps = 15/276 (5%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKV---GGKGLFVK 64 + TR S LA+ Q L A+ P + +E VTRGD LD L + GGKGLF K Sbjct: 6 LGTRASALAVAQVELTTKALAAAFPAMQIERREFVTRGDKKLDLSLLRANEAGGKGLFTK 65 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 ELE ALL D+AVHS+KD+P P GL + + ER D ++ +L LP G + Sbjct: 66 ELEDALLNGSIDVAVHSLKDLPGHNPPGLDITAVLERAPTADVLITKQPQTLLDLPQGVL 125 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-DNGEYDAIILAVAGLKRLG----- 178 +GTSS+RR QL RRPD+ + RGNV TRL KL + + IILA AGL+RLG Sbjct: 126 LGTSSVRRARQLQWRRPDVRVEEWRGNVQTRLRKLAERDDVTGIILAQAGLERLGHDLSA 185 Query: 179 --LES---RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERA 233 LE+ + E LPA+GQGA+ ++ R D + +L ++H ET L + AER Sbjct: 186 GRLETEHGKFYVTSLAEDLLPAIGQGAIALQSRADRAEVAAVLQKIDHRETHLAIRAERE 245 Query: 234 MNTRLEGGCQVPIGSYAELIDGEIWLRA-LVGAPDG 268 + L G C +P+G +L+ G I +RA L G PD Sbjct: 246 LQRLLAGDCALPVGVRTKLLPGGIAMRAILFGPPDA 281 >UniRef50_UPI000174444E Hydroxymethylbilane synthase n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI000174444E Length = 318 Score = 176 bits (446), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 117/278 (42%), Positives = 152/278 (54%), Gaps = 16/278 (5%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG---- 57 + LR+ TR S LAL QA V+ L A+HP L VE + T GD D ++ Sbjct: 5 FTDTLRLGTRGSELALRQAEMVEAALHAAHPYLRVERKVIATTGDKRPDLRFSEFTEGDR 64 Query: 58 -GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSL 116 KG+F KELE+AL DIAVHS+KDVP + + + R D +S +L Sbjct: 65 LDKGIFTKELEIALASGEIDIAVHSLKDVPTVLDEKFFIAGVLPRAPIEDVLISREGYTL 124 Query: 117 DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-DNGEYDAIILAVAGLK 175 LPAG+ VGTSS+RR QL P + +RGNV TR+ KL + DAI+LA AGL+ Sbjct: 125 ATLPAGAKVGTSSVRRIRQLQWLNPGVECVEIRGNVPTRIRKLFAPSDLDAILLARAGLE 184 Query: 176 RLGL----------ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETA 225 RL L + L E LPA GQGA+GIE R+DD+ T E L A+NH ET Sbjct: 185 RLSLLDGEHVVVDGQPLHAVILDCEEFLPAAGQGAIGIEARVDDAHTLEFLKAINHEETY 244 Query: 226 LRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALV 263 RVTAER L+ GCQ PIG++ L +G + ++ V Sbjct: 245 ARVTAEREFLHILKAGCQTPIGAHTFLENGVLQMKVRV 282 >UniRef50_Q1GP41 Porphobilinogen deaminase n=7 Tax=Sphingomonadales RepID=HEM3_SPHAL Length = 315 Score = 176 bits (445), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 130/279 (46%), Positives = 165/279 (59%), Gaps = 7/279 (2%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLV--VELVPMVTRGDVILDTPLAKVGGKG 60 DN LRI TR SPLA+ QAH L+A+H + +E+VPM GD I D LA+VGGK Sbjct: 8 DNPLRIGTRASPLAMAQAHMAAAALIAAHGLAMAALEIVPMTATGDRIQDRALAEVGGKA 67 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLD 117 L+ +EL+ AL D+AVHS+KDV L + ER DPRD V + Sbjct: 68 LWTRELDAALDAGTIDVAVHSLKDVETLRDARFFLGAMLERADPRDRLVVREGIAAQKIS 127 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177 LP G+ +GTSS RR Q+ RPDL LRGNV TRL+KL GE DA +LA AGL+RL Sbjct: 128 ELPHGARLGTSSPRRAAQVRRLRPDLDTVLLRGNVATRLAKLAAGEADATLLAAAGLERL 187 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 G+ I A E+ LPA QGA+GIECR DD+ T LLAA++H T V AERA+ Sbjct: 188 GMHD-IGAVQGTELLLPAASQGAIGIECRADDAATIALLAAIDHAPTHRAVAAERALLAV 246 Query: 238 LEGGCQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGE 275 L G C+ P+ +YAE DG + L A + + DG+ + G Sbjct: 247 LGGDCRSPVAAYAEWQADGVLRLDAEIFSEDGADHVAGH 285 >UniRef50_UPI0001BC2D4C glutamyl-tRNA reductase n=1 Tax=Brevibacterium linens BL2 RepID=UPI0001BC2D4C Length = 825 Score = 176 bits (445), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 109/277 (39%), Positives = 158/277 (57%), Gaps = 15/277 (5%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +R+ TR+S LA Q+ + +L A+ G VE+V +VT GDV + +PL GG G+FV Sbjct: 478 TIRLGTRRSKLARSQSTAIAHQL-AALTGWRVEIVEVVTEGDVNM-SPLTGFGGTGVFVS 535 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 + AL + + DIAVHS+KD+P G+ + I R DP D + + S LPAGS+ Sbjct: 536 AVRQALHQGKIDIAVHSLKDLPTTPEAGIQMAAIPPRVDPADVLIGRDGLSFAELPAGSV 595 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGT S RR QL RPD+ +R +RGNV TR++ + +G DA++LA AG++R+G + Sbjct: 596 VGTGSPRRAVQLRAARPDIEVRGVRGNVDTRIAHVRDGRLDAVVLAAAGVRRIGRLAEAT 655 Query: 185 AALPPEISLPAVGQGAVGIECR-------LD------DSRTRELLAALNHHETALRVTAE 231 +L + LPA GQGA+ +E R LD D+ R L L+ T L VT E Sbjct: 656 DSLDFDTMLPAPGQGALAVETRGADSPFALDNEVMEADAEVRTQLKRLHDETTDLAVTCE 715 Query: 232 RAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDG 268 RA+ +R E GC PIG+ A + + + A++ DG Sbjct: 716 RAILSRAEAGCSAPIGALATIQGSDFVVDAVMADDDG 752 >UniRef50_A4XK06 Porphobilinogen deaminase n=2 Tax=Clostridia RepID=HEM3_CALS8 Length = 290 Score = 175 bits (444), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 106/291 (36%), Positives = 155/291 (53%), Gaps = 8/291 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LRI R S L+ Q V K+ + G+ E VP+ T+GD+ L G+FVKE Sbjct: 4 LRIGARDSKLSRIQVDIVARKIKQT-LGIECEFVPIKTKGDIDKTKSLKDFKSPGVFVKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E+ALL D+AVHS+KD+P E +V + EREDPRD VS + L + + Sbjct: 63 IELALLSREIDLAVHSLKDLPCEMDSNFEIVAVVEREDPRDVLVSKDGVGFYQLKPNAKI 122 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR+ L R D+ + ++RGN+ TRLSK+++ D ++LA A LKRL L+S + Sbjct: 123 GTSSLRREVHLKNLRQDIQVVNIRGNIETRLSKIESEGLDGVVLAYAALKRLNLDSHVSY 182 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 P GQGA+ IEC L DS + +L+ +N + ++ ER + L GGC Sbjct: 183 IFDVNEITPCPGQGAICIEC-LKDSPYKNILSKINDADAYIQTQFERLVLKFLGGGCHSS 241 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 IG + + +I+ A G ++I+ G D +SLA +L N Sbjct: 242 IGVFCKTDQDKIY--AFASILSGDKLIKASIEGDKDDF----LSLANKLSN 286 >UniRef50_C6XKH7 Porphobilinogen deaminase n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XKH7_HIRBI Length = 323 Score = 175 bits (444), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 109/271 (40%), Positives = 147/271 (54%), Gaps = 7/271 (2%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLV-VELVPMVTRGDVILDTPLAKVGGKGLF 62 +++I R SPLA+ QA + V +E+ T GD +LD L GGKGLF Sbjct: 19 QIVKIGARGSPLAVQQAEDFAARFKEIVGNTVEIEIHTFTTSGDQLLDKRLQDAGGKGLF 78 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 +EL++A L R DI VHS+KDVP P GL + REDPRDA ++ LP G Sbjct: 79 TRELDIAQLSGRIDIVVHSLKDVPTVLPDGLQMGCYLPREDPRDALFGK-VGNIKDLPHG 137 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 + +GT+SLRR Q RPDL I RGNV TRL KL+ G+ DA +LA AGL RLG+ + Sbjct: 138 ATLGTASLRRSAQALALRPDLKIVMFRGNVQTRLRKLEEGQADATLLAAAGLNRLGMTDK 197 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAA---LNHHETALRVTAERAMNTRLE 239 +P E LPA GQG V L ++ + A ++ E+ + AERA RL+ Sbjct: 198 AAGFMPKEEMLPACGQGIVCTT--LTNNAEDWIFKACLQIDVLESRIAAIAERAFLKRLD 255 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQ 270 G C+ PI + + + +R V A DGS+ Sbjct: 256 GSCRTPIAGHLSFNETGVDMRGEVLADDGSK 286 >UniRef50_C7R376 Porphobilinogen deaminase n=1 Tax=Jonesia denitrificans DSM 20603 RepID=C7R376_JONDD Length = 344 Score = 174 bits (442), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 129/342 (37%), Positives = 174/342 (50%), Gaps = 47/342 (13%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LR+ TR S LA Q+ L+A G+ V+L + T GDV+ + LA +GG G+FV Sbjct: 4 LRLGTRASALATAQSRATA-ALIAQATGVTVDLTHIRTDGDVLTGS-LATMGGAGVFVTA 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 + ALL DIAVHS+KD+P +G ++ + ERE+P+DA S + +SL LP G++V Sbjct: 62 IRQALLAGDIDIAVHSLKDLPTTPHEGTTII-VPERENPQDALCSRHGESLAHLPHGALV 120 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD---------NGEYDAIILAVAGLKR 176 GT S RR QL RPDL I +RGNV TRL+++ + DA++LA AGL+R Sbjct: 121 GTGSPRRAAQLLVARPDLRIVDIRGNVDTRLARVGLSTADKPHIRNDLDAVVLAAAGLRR 180 Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAA----LNHHETALRVTAER 232 LG I LPP LPA GQGA+ IE R D + + A L+H TA V AER Sbjct: 181 LGRAHVISELLPPTSMLPAPGQGALAIEVRHDMADHHPSILAGIRTLHHQPTAYAVAAER 240 Query: 233 AMNTRLEGGCQVPIGSYAEL-----------IDGEIWLRALVGAPDGSQIIRGERR--GA 279 A+ LE GC P+G+ A + +D + A P + I A Sbjct: 241 AVLRHLEAGCAAPVGALATMHNTTLTLTATALDPRLTPTAHTPTPSTTTDINAAPTPMTA 300 Query: 280 P------------------QDAEQMGISLAEELLNNGAREIL 303 P DA + GI+LA LL +GA E L Sbjct: 301 PADARPPIRLTHTHTVTSENDATEAGITLATTLLTHGAAEFL 342 >UniRef50_D2RNT2 Porphobilinogen deaminase n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RNT2_ACIFE Length = 288 Score = 174 bits (442), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 119/294 (40%), Positives = 165/294 (56%), Gaps = 16/294 (5%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67 +ATR S LAL Q H V L G+ E+ + T GD L K+GG+G+FV+E+E Sbjct: 6 VATRGSRLALAQTHIVCRLL--EEAGVETEIRTITTAGDRDRIHALVKIGGRGIFVREIE 63 Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127 LL ADIAVHS KD+P + GL + + DPRDA V L+A GS+VGT Sbjct: 64 RELLSGEADIAVHSAKDLPYQLASGLVIAGTPSQADPRDALVLLKERKLEA---GSVVGT 120 Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL---ESRIR 184 S RR +++ P+L+ R +RGNV TRL KL+ GEYDAI+LA+AG++RL L + +IR Sbjct: 121 GSPRRIREISRVLPELVFRDIRGNVTTRLHKLERGEYDAIVLAMAGIQRLALDMEQFQIR 180 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L E +PA QG +G+ECR D LL ++ ET R ER + T ++ C Sbjct: 181 -PLSTEQVIPAGCQGIIGVECRQKDRELVRLLQQISDPETWRRFQWERQLFTSMKVDCSR 239 Query: 245 PIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 P+G + L+ G + L A+V DG R R G ++ + + SL EEL + Sbjct: 240 PVGIHCRLLKSGRMELLAMV---DGK---RARRLGMEKEGKALCASLKEELYDR 287 >UniRef50_Q46CH0 Probable porphobilinogen deaminase n=7 Tax=Euryarchaeota RepID=HEM3_METBF Length = 316 Score = 174 bits (441), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 111/270 (41%), Positives = 155/270 (57%), Gaps = 11/270 (4%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG-GKGLFVKEL 66 I TR S LAL QA V L A G+ L + T GD D PL V G G FV+EL Sbjct: 3 IGTRGSQLALAQAETVARLLKAK--GVETSLKIIKTSGDRFTDRPLHAVSSGVGAFVREL 60 Query: 67 EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126 + +LE + DIAVHSMKD+P P L V + +R+ P D ++ + LD L SI+G Sbjct: 61 DEVMLEGKIDIAVHSMKDMPTIRPPTLPTVAVLKRDTPFDLLLTYDGTPLDELSEQSIIG 120 Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG--LESRIR 184 TSSLRR Q+ RPDL+ + LRGN+ TRL KL G+YD I+LA AGL+R+G LE I Sbjct: 121 TSSLRRAAQIKRYRPDLVTQDLRGNIDTRLRKLKEGKYDGILLAKAGLERMGWELEGEI- 179 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L P+ P+ QG + + R ++ ++ L+H ++ + ER + + L GGC Sbjct: 180 --LSPDFFCPSPNQGTIAVVTRA-ETEAEAAVSRLDHTDSRIATEIERILISELGGGCTT 236 Query: 245 PIGSYAELID--GEIWLRALVGAPDGSQII 272 PIGSYAE++ ++ +RA V + DG + + Sbjct: 237 PIGSYAEIMPDRKKLHVRAEVLSLDGEETV 266 >UniRef50_C2GGB5 Porphobilinogen deaminase n=2 Tax=Corynebacterium glucuronolyticum RepID=C2GGB5_9CORY Length = 290 Score = 172 bits (437), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 120/299 (40%), Positives = 166/299 (55%), Gaps = 11/299 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR S LA QA +V+D L+ + G EL + T GD L +P+ K+G G+F + Sbjct: 2 TLRIGTRGSKLATTQAGHVRDALIRA--GYDAELTIITTPGDKNL-SPVQKIG-VGVFTQ 57 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L A+ + DIAVHS KD+P P+GL + RE P +A ++ + +LD LP G+ Sbjct: 58 ALREAMDRDEIDIAVHSCKDLPTGQPEGLATIYPV-RETPCEALIARDGLTLDQLPEGAK 116 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGT + RR QL RPDL IR LRGNV TR+ K+ +GE DA+ILA AGL R+G Sbjct: 117 VGTGAPRRISQLKALRPDLDIRPLRGNVDTRMGKVTSGELDAVILAHAGLTRIGRGDEAT 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 P +PA QG + +E R + + ++ H T L AERA+ + L+ GC Sbjct: 177 QVFDPTYLMPAPAQGILAVESR---THVDAISTLIDDHAT-LSAQAERAVLSTLQAGCTA 232 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 P+ +Y+ + EI L A A DGS+ I G D +G S+AE+L GA EI+ Sbjct: 233 PLAAYSTVSGDEITLTAGAFALDGSKQIVETATGT--DPVALGTSVAEKLRACGAEEII 289 >UniRef50_C8WDJ7 Porphobilinogen deaminase n=3 Tax=Zymomonas mobilis RepID=C8WDJ7_ZYMMN Length = 308 Score = 172 bits (436), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 123/302 (40%), Positives = 169/302 (55%), Gaps = 11/302 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGL--VVELVPMVTRGDVILDTPLAKVGGKGLFV 63 R+ +R SPLAL QA V L A+H V +VP+ T GD LA +GGK L+ Sbjct: 5 FRLGSRGSPLALIQARSVASALCAAHSWSEDAVVIVPIRTSGDKNRHQALADIGGKALWT 64 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KEL++AL + D AVHSMKDV P + + + RED D + SL+ LP Sbjct: 65 KELDIALTTGQIDAAVHSMKDVETFRPSHISIAAMLPREDVHDRLI--GIPSLEVLPYSG 122 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGT+S RR Q+ RPD+ I+ LRGN+ TRL KL N ++DA +LA AGL RLG + + Sbjct: 123 CVGTASPRRAAQIRRIRPDIEIKLLRGNIDTRLEKLANKQFDATLLAAAGLIRLG-RNDV 181 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 +P + LPA GQGA+GIE L DS E ++ ++H+ T L V +ER + RL C Sbjct: 182 GYDVPLDQMLPAAGQGAIGIEA-LADSAAWEKVSIIDHYPTHLAVQSERQLLLRLNADCH 240 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-GAPQDAEQMGISLAEELLNNGAREI 302 PI +AE+++ I LRA + +G ++ P DA ++G SL LLN E+ Sbjct: 241 SPIAVFAEILEKNIRLRACLYTENGKFSASIDKEISQPSDAFEVG-SL---LLNQSPPEV 296 Query: 303 LA 304 A Sbjct: 297 QA 298 >UniRef50_C2FZW8 Porphobilinogen deaminase n=2 Tax=Sphingobacterium spiritivorum RepID=C2FZW8_9SPHI Length = 528 Score = 170 bits (431), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 115/312 (36%), Positives = 162/312 (51%), Gaps = 26/312 (8%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 ++ L I TR S LA+WQA+++KD+L A+ G+ EL + T+GD+I L K+ GKG Sbjct: 1 MNRKLIIGTRGSQLAMWQANHIKDRLAAA--GIDSELKVIKTQGDIIQHLRLDKLEGKGF 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD---- 117 F KELE LL + D+AVHS KD+P P GL + + ERE P + + D +D Sbjct: 59 FTKELEEELLSSTIDLAVHSHKDLPTVNPPGLIIAAVSERESPAELLIVLK-DCVDIKKR 117 Query: 118 -ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKR 176 +L + VGTSS RR+ QL RPDL LRGN+ TR+ KL + YDAIILA AG++R Sbjct: 118 LSLKHNATVGTSSNRRKAQLLSLRPDLEFDDLRGNLQTRIQKLRDENYDAIILAKAGVER 177 Query: 177 --LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234 + L +PP +PA QG + I+ R D E L +++ E A + ER + Sbjct: 178 IDMDLSDFYVEEIPPVELIPAPAQGVLAIQIRESDQELFEALQVIHNKEVAEVIAVERKV 237 Query: 235 NTRLEGGCQVPIGSYAELIDG--EIWLRALVGA---PDGSQIIRGERRGAPQDAEQMGIS 289 + GC P+G Y +G E W + PD I R G Sbjct: 238 LNLFDAGCHAPLGCYCRKSEGKYEAWTSVAETSDEFPDRLYIQRDSTEG----------- 286 Query: 290 LAEELLNNGARE 301 +AEE+ A++ Sbjct: 287 MAEEIFTKFAKD 298 >UniRef50_A8AAB4 Probable porphobilinogen deaminase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=HEM3_IGNH4 Length = 304 Score = 169 bits (429), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 120/297 (40%), Positives = 164/297 (55%), Gaps = 17/297 (5%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTP---LAKVGGKGLF 62 ++IA R S L+L Q L+ P L E++ + T GD + P LAK G GLF Sbjct: 3 IKIAARGSKLSLKQVSMFTSYLLKFFPDLEYEVITVKTTGDKA-NAPFEELAKRGLTGLF 61 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN--NYDSLDALP 120 KE+ A+LE +AD+AVHS+KD+P E L + R+ P D +S NYD D LP Sbjct: 62 EKEVNKAVLEGKADVAVHSLKDLPTELDPRLEIAAFLPRDPPYDVLISRAGNYDIFD-LP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 GS+VGTSS RR+ + RPDL+++ LRGNV TRL KL GEYDAI+LA AG+ RLGL Sbjct: 121 KGSVVGTSSARRKALIKNLRPDLVVKDLRGNVDTRLEKLRRGEYDAIVLAEAGVSRLGLN 180 Query: 181 ---SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 R+ L P P+ GQG + R S +LL +++ ++ TAER + Sbjct: 181 VDYVRLDWRLFP----PSPGQGIIVAVTR-KGSEISDLLKSISDVKSEKLATAERTVLKE 235 Query: 238 LEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 GGC V +G+ A I LRA V +P G + + E G + E++G+ AE L Sbjct: 236 FGGGCFVALGAIAFEEGSLIRLRATVLSPSGRERVDVELIG--KGPEEVGMRAAERL 290 >UniRef50_D1VCA1 Porphobilinogen deaminase n=1 Tax=Frankia sp. EuI1c RepID=D1VCA1_9ACTO Length = 380 Score = 169 bits (429), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 123/344 (35%), Positives = 181/344 (52%), Gaps = 44/344 (12%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 L + LR+ TR+S LAL Q+ V D+L + G+ V+LV +VT GD ++++G G+ Sbjct: 36 LPSRLRLGTRRSALALAQSGMVADELR-TRLGIEVDLVHVVTEGDRN-RAEISQLGSTGV 93 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 +V L ALL D+AVHS+KD+P P+G+ L I RED RD VS +L L Sbjct: 94 WVSALREALLSGEVDLAVHSLKDLPTAPPEGITLAAIPPREDVRDVLVSPTGRTLAQLGP 153 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ +GT + RR QL L + +RGNV TR+ K +GE DA++LA AGL RL Sbjct: 154 GARIGTGAPRRAAQLRALGLGLDVVPIRGNVDTRIKKAIDGEVDAVVLARAGLARLDRLD 213 Query: 182 RIRAALPPEISLPAVGQGAVGIEC---------------------------------RLD 208 I L PE+ LPA GQGA+ IEC ++ Sbjct: 214 AITELLEPEVMLPAPGQGALAIECVATTLAPLTLLTVGTPEDQGAVTGMSCPVAPGSGVE 273 Query: 209 DSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELI---------DGEIWL 259 R L L+ +++ V AERA +E GC P+G+ A+++ +GE+ L Sbjct: 274 IPLERLLRFVLDDAPSSVAVRAERAFLAAIEAGCTAPVGALAQVLPARGQAPASEGEVRL 333 Query: 260 RALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 RA+V + DG+ ++R E G+ D E +G LA++LL+ GA ++ Sbjct: 334 RAVVASLDGTTVLRRELGGSTADPEALGRRLADDLLSAGAHTLM 377 >UniRef50_UPI0001C31A39 porphobilinogen deaminase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31A39 Length = 314 Score = 169 bits (427), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 132/288 (45%), Positives = 169/288 (58%), Gaps = 13/288 (4%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +VLRI TR S LAL QA +V L G VE++P+ T GD +G K +V Sbjct: 2 SVLRIGTRASALALVQAEHVASLLRDG--GAQVEVIPITTSGDRGR-----LLGDKSRWV 54 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE ALL + D+AVHS KDVP E P G L + R D RDA SL+ LP G+ Sbjct: 55 KELEAALLADEVDVAVHSAKDVPAELPDGFVLAGVPARADARDALC--GAASLEQLPDGA 112 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +VGTSSLRR +L RPDL + +LRGNV TRL KL +G+ AI+LAVAGL+RL + I Sbjct: 113 VVGTSSLRRAAELRALRPDLGVVALRGNVDTRLRKLADGQAAAIVLAVAGLERLDRGAAI 172 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 A L + +PA GQGA+ +E R DD R R AA+ + A + AERA+ RL C Sbjct: 173 GAVL--DQLVPAPGQGALALETRADDDRARAAAAAITDADAAACLAAERALVRRLGATCH 230 Query: 244 VPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAPQ-DAEQMGIS 289 P+G++A DG + LR+ VG PDGS +R E A D E G++ Sbjct: 231 TPLGAHAVRTADGGLRLRSFVGLPDGSAWLRDELSAAAGIDPETFGVA 278 >UniRef50_A9V9E0 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V9E0_MONBE Length = 643 Score = 168 bits (426), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 101/206 (49%), Positives = 125/206 (60%), Gaps = 8/206 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LA+WQ +V ++L +HPG+ +VP+ T GD L L K G+F Sbjct: 417 IRIGTRSSVLAMWQTRWVVERLTRAHPGVRFSVVPLSTVGDANLTLDLNKFSTTGIFTDA 476 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS----LDALPA 121 L ALL DI VHS+KD+P G L I REDPRD V ++ S L LPA Sbjct: 477 LVRALLAQEVDILVHSLKDLPSTISPGTQLAAIGPREDPRDVVVFHHRHSEIKDLAQLPA 536 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD---NGEYDAIILAVAGLKRLG 178 G++VGTSS RR+ QLA P L +RGNV TRL KLD NG YDA+ LA AGL RLG Sbjct: 537 GAVVGTSSTRRRAQLAAAYPQLRFAPVRGNVMTRLRKLDDPANG-YDALCLAAAGLIRLG 595 Query: 179 LESRIRAALPPEISLPAVGQGAVGIE 204 LE+RI LP +S A+GQGA+GI+ Sbjct: 596 LEARIGQFLPLTVSRHAIGQGALGIQ 621 >UniRef50_B5JN62 Porphobilinogen deaminase n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JN62_9BACT Length = 291 Score = 168 bits (426), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 106/243 (43%), Positives = 132/243 (54%), Gaps = 11/243 (4%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67 IATR+SPLA+ Q H K+ P V + MVT GD + L K GGKGLF KELE Sbjct: 10 IATRKSPLAMAQTHLAKELFQRGMPDAVFRIEKMVTTGDKRQEWSLEKQGGKGLFTKELE 69 Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127 ALLE RAD AVHS KD+P E P+GL L R+ D + D + + ++ T Sbjct: 70 DALLEGRADFAVHSAKDLPSEMPKGLALAGFLPRQTCEDVLILR-----DGVESPKLIAT 124 Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR---IR 184 S RR+ QL P +RGNV TRL+K+ G+ DA +LA AGL RLG+ES Sbjct: 125 GSPRRRIQLRYLFPKAEFTEIRGNVDTRLTKIARGDADATVLASAGLNRLGIESWEGVTF 184 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L + +PAVGQ AV I+CR +D T A ETA+ V ER+ L GGCQV Sbjct: 185 RKLTLDECVPAVGQAAVAIQCREEDVDT---FRAHLDEETAIAVNLERSFLEELGGGCQV 241 Query: 245 PIG 247 Sbjct: 242 AFA 244 >UniRef50_D1C4S0 Porphobilinogen deaminase n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C4S0_SPHTD Length = 311 Score = 167 bits (422), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 117/259 (45%), Positives = 147/259 (56%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +R+ TR S LA Q V L A P L + + T GD TPL +GG+G+F +E Sbjct: 11 VRLGTRGSALAREQTRRVMAALAALRPDLELIETIVSTAGDRDKRTPLTVIGGQGVFARE 70 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L+ ALL D+AVHS KD+P E GL + RED RD VS + SL LP G+ V Sbjct: 71 LQTALLAGTVDVAVHSAKDLPTEPVPGLVIGAFFSREDARDVLVSRDGRSLADLPPGARV 130 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS RR L RPDL LRGN+ TRL K+ GE DA ILA AGL R+G + I Sbjct: 131 GTSSRRRLVALRRLRPDLEAVDLRGNLDTRLRKVREGEVDAAILAAAGLLRMGWQEHITE 190 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L + +PA GQGA+ IECR DD E+LAALN AL ER+ L GGC+ P Sbjct: 191 FLSLDDFVPAPGQGALAIECRADDPAVNEMLAALNDPAAALAARTERSFLRALGGGCRSP 250 Query: 246 IGSYAELIDGEIWLRALVG 264 IG++A + + LR ++G Sbjct: 251 IGAHATVSGDTVTLRVMLG 269 >UniRef50_B6W7F3 Putative uncharacterized protein n=1 Tax=Anaerococcus hydrogenalis DSM 7454 RepID=B6W7F3_9FIRM Length = 318 Score = 167 bits (422), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 109/310 (35%), Positives = 163/310 (52%), Gaps = 12/310 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +++I +R S LAL QA+ VKD L GL ++V + T+GD I D + ++ KG+FV+ Sbjct: 1 MIKIGSRASKLALIQANMVKDIL--EKEGLEAQIVEISTKGDRIRDRKIDQLNSKGVFVR 58 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALPAGS 123 E+E LL+ DIAVHS+KD+P + L + EDPRD FV + + +D L + Sbjct: 59 EIEEKLLDKTIDIAVHSLKDMPSQIDDRLIFTPPLKGEDPRDCFVGKDVFKKMDDL-NNA 117 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +VGT S RR CQ ++ +++RGNV TR+ K+ + D +ILA +GL R GL+ I Sbjct: 118 LVGTGSNRRVCQGKNHFSNIKFKAIRGNVETRIKKVQSENLDGVILAKSGLIRAGLDGEI 177 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 L P I P+ QG +GIE R +D + E+ + +T R+ ERA L C Sbjct: 178 NFDLDPHIFTPSPCQGILGIEIRKEDKKLFEIFKKNSDEKTLFRMETERAFQKELGADCS 237 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 P+G + E+ +I L + A D I ER I LA++L AR + Sbjct: 238 TPMGIFTEIDHDKITLTGSM-AFDKDDRINYERVSGNISER---IHLAQKL----ARTLK 289 Query: 304 AEVYNGDAPA 313 + Y + P Sbjct: 290 KKSYKKNNPC 299 >UniRef50_Q6AHF1 Porphobilinogen deaminase n=5 Tax=Actinobacteria (class) RepID=HEM3_LEIXX Length = 329 Score = 166 bits (421), Expect = 8e-40, Method: Compositional matrix adjust. Identities = 121/315 (38%), Positives = 168/315 (53%), Gaps = 21/315 (6%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 LR+ TR SPLA+ Q V +A G +ELV + T GD ++ L+++GG G+F Sbjct: 13 GALRVGTRGSPLAVAQTQAVS-AAVARATGFDIELVTVTTHGDTSRES-LSELGGTGVFA 70 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 L AL D+ VHS+KD+P GL L + +R D RD + + LP G+ Sbjct: 71 TALRDALRNGECDLVVHSLKDLPTAPAPGLVLGAVPKRADARDTLCARDGLRFGELPEGA 130 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGT S RR QL +RP L I +RGNV TRLS++ G+ DA++LA AGL RLG R+ Sbjct: 131 SVGTGSPRRAAQLRAQRPGLDIVDIRGNVDTRLSRVSAGDLDAVVLAAAGLGRLG---RL 187 Query: 184 RAA--LPPEISLP-AVGQGAVGIECRLDDSRTR----ELLAALNHHETALRVTAERAMNT 236 AA ++P A GQGA+ +E R D R R LAA++H T TAERA+ Sbjct: 188 DAATDFFSLSTMPTAPGQGALALEVREGDERGRGPIARALAAVDHATTCAATTAERAVLA 247 Query: 237 RLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAP---------QDAEQMG 287 LE GC P+G+ A + DG ++L A V PDG+ + P + A +G Sbjct: 248 GLEAGCAAPVGATAMIDDGLLFLTATVYRPDGAAQLTASHAATPDSFGAAHLDEAARDVG 307 Query: 288 ISLAEELLNNGAREI 302 + ELL +GA ++ Sbjct: 308 ERVVAELLASGAADL 322 >UniRef50_C5C5B3 Porphobilinogen deaminase n=6 Tax=Actinomycetales RepID=C5C5B3_BEUC1 Length = 334 Score = 166 bits (419), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 119/270 (44%), Positives = 155/270 (57%), Gaps = 13/270 (4%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMA-----SHPGLVVELVPMVTRGDVILDTPLAKVGGK 59 LR+ TR S LA Q+ + + + A + + VELV + T GDV+ + LA +GG Sbjct: 21 TLRVGTRASALATTQSEWAGEAIAARVAAATGSDVEVELVRVTTTGDVLTGS-LASMGGT 79 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 G+FV L ALL+ R D+AVHS+KD+P GL L + +REDPRD + L L Sbjct: 80 GVFVTALREALLDGRCDVAVHSLKDLPTAAAPGLVLGAVPQREDPRDVLCARAGAGLADL 139 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLKRL 177 PAG VGT S RR QL RPDL I +RGNV TRLS++ G+ DA++LA AGL RL Sbjct: 140 PAGGRVGTGSPRRAAQLRRARPDLEIVDIRGNVDTRLSRISPGKGDLDAVVLARAGLARL 199 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHE---TALRVTAERAM 234 G + AL + +PA GQGA+ +E D+ LLA L + T L VTAERAM Sbjct: 200 GRLDAVTEALDAGVMVPAPGQGALAVEAV--DAAPDWLLAGLRAFDDAPTRLAVTAERAM 257 Query: 235 NTRLEGGCQVPIGSYAELIDGEIWLRALVG 264 RLE GC P+G+ A L ++ LR VG Sbjct: 258 LARLEVGCSAPVGALATLAGSQLLLRTSVG 287 >UniRef50_A6LKX0 Porphobilinogen deaminase n=1 Tax=Thermosipho melanesiensis BI429 RepID=A6LKX0_THEM4 Length = 279 Score = 164 bits (415), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 94/247 (38%), Positives = 143/247 (57%), Gaps = 6/247 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +R+ TR+S LAL Q V +KL P + E+ P+VT+GD L TP+ K+GGKG+FV + Sbjct: 3 IRVGTRKSKLALIQTQLVVNKLKELLPNIDFEITPVVTKGDR-LKTPIDKIGGKGVFVSD 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E +L+++ DIA+HSMKD+P + P L L ++ +RE P D F+ ++ L G+ + Sbjct: 62 IEKLILDDKLDIAIHSMKDLPSKIPDKLFLTSVLKRECPNDVFIGK--ENFFNLKKGAKI 119 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS RR Q+ RPD+ I +RGNV TR+ K+ GE D I++A AG+ RLGL+ +I Sbjct: 120 GTSSKRRALQINMLRPDIEIVPIRGNVDTRIKKI--GELDGIVIAAAGVIRLGLKDKITN 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSR-TRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 E +PA QG + +E + E+ + +T + ER + + L C Sbjct: 178 LFEFEKIVPAPCQGILALEFSEKFLKPFEEIKDVIVDPKTEVETQIERKILSLLNFDCNT 237 Query: 245 PIGSYAE 251 P G Y + Sbjct: 238 PFGFYCD 244 >UniRef50_Q5KKQ0 Hydroxymethylbilane synthase, putative n=2 Tax=Filobasidiella neoformans RepID=Q5KKQ0_CRYNE Length = 481 Score = 164 bits (415), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 106/288 (36%), Positives = 142/288 (49%), Gaps = 37/288 (12%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPG-------------------------LVVEL 38 N + TR+S LAL Q +V D L H G + Sbjct: 31 NTFILGTRKSNLALVQTGHVADDLRRLHSGAGSKFGETREEGDDAEQGDVPFVHPYTFSI 90 Query: 39 VPMVTRGDVILDTPL-------AKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQ 91 M T GD TPL + K L+ ELE L+ D+ VHS+KDVP Sbjct: 91 ESMTTVGDRNQTTPLHLLSPYSSTQPAKSLWTDELEARLINGHFDMLVHSLKDVPTVLKD 150 Query: 92 GLGLVTICEREDPRDAFVSNN---YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSL 148 G + + +R DPRDA V Y L+ LP G++VGT S+RR QL P+L+ + Sbjct: 151 GCEIGCMAKRHDPRDALVVKQGLPYKRLEDLPDGAVVGTGSVRRVAQLKRAFPNLVFEDM 210 Query: 149 RGNVGTRLSKLDNGE--YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECR 206 RGN+ TR +KLDN + + A+ILA++GL+RLG+ R + L + AVGQGA+ IE R Sbjct: 211 RGNLNTRFNKLDNPQSPFSALILAMSGLERLGMAHRATSPLSSPTLMHAVGQGALAIEIR 270 Query: 207 LDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID 254 D R R L L H +T AER LEGGC VP+G +EL++ Sbjct: 271 STDPRVRNCLRGLGHWQTEWSCGAERGCLRVLEGGCSVPVGVESELVE 318 >UniRef50_A4WN24 Probable porphobilinogen deaminase n=3 Tax=Thermoproteaceae RepID=HEM3_PYRAR Length = 297 Score = 164 bits (414), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 102/247 (41%), Positives = 142/247 (57%), Gaps = 2/247 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L +ATR S L++ Q + ++ A P + E+ + T GD + D PL ++G KG+F KE Sbjct: 3 LVVATRGSKLSMLQTEELLAQIKAVEPSIEFEIKIVKTTGDEVQDKPLYQIGVKGIFEKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 + +A+L AD+AVHS+KD+P E GL L +R P DA VS L+ LP G++V Sbjct: 63 VNLAVLRGEADVAVHSLKDLPSELSPGLVLAGFSKRAPPFDAVVSTAGYVLETLPRGALV 122 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL-GLESRIR 184 GTSS+RR + RPD+ + LRGNV TR++K+ G+YDA I+AVAG+ RL G I+ Sbjct: 123 GTSSVRRAEFVKAIRPDVRVEPLRGNVDTRINKILQGKYDAAIMAVAGIYRLYGASPPIK 182 Query: 185 -AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 A L PE+ P GQG V R DS +LL + + +L AER + GC Sbjct: 183 LAVLRPEVLPPPPGQGIVAAVVREADSWLIDLLKKASDPKASLEAIAEREFLKAVGAGCH 242 Query: 244 VPIGSYA 250 V IG A Sbjct: 243 VAIGGVA 249 >UniRef50_B2ULP1 Porphobilinogen deaminase n=1 Tax=Akkermansia muciniphila ATCC BAA-835 RepID=B2ULP1_AKKM8 Length = 325 Score = 163 bits (413), Expect = 6e-39, Method: Compositional matrix adjust. Identities = 126/318 (39%), Positives = 164/318 (51%), Gaps = 27/318 (8%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG------ 57 N L I TR S LAL QA V+ L +P L V + T GD D PLA V Sbjct: 5 NTLIIGTRGSALALAQADMVRAALSLRYPELDVRCEIIHTIGDRRTDVPLADVARVSGMV 64 Query: 58 GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD 117 KG+F+KELE AL + R D+AVHS+KDVP E G L + R D ++ D Sbjct: 65 DKGIFIKELETALRDGRIDVAVHSLKDVPSELAAGFTLAAVLPRAAVEDVLITKEPDWNG 124 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-DNGEYDAIILAVAGLKR 176 + G++ S RR L +LRGNV TRL KL ++ +DA+ILA AGL+R Sbjct: 125 S---GTLATGSVRRRLMARTYWGSGLRFENLRGNVPTRLGKLVEHPGWDAVILARAGLER 181 Query: 177 LGL---ESRIRA------ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALR 227 LGL E+ + LP E+ +PAVGQG VG+ECR D T E+L +N E+ Sbjct: 182 LGLYAPETLVEGRKLYMRPLPVEVFIPAVGQGIVGMECRSSDRETAEMLEGINDPESFAC 241 Query: 228 VTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQ----IIRGERRGAPQDA 283 AERA RL C P+G YA E+ LRA P + +IRG+R+ AP Sbjct: 242 ALAERAFLVRLGANCSTPVGVYAHPDGEELVLRAAYYVPGREEPFAVVIRGDRK-AP--- 297 Query: 284 EQMGISLAEELLNNGARE 301 E +G+ EEL +G R+ Sbjct: 298 EALGLRAFEELGLSGWRK 315 >UniRef50_B0WMK9 Porphobilinogen deaminase n=1 Tax=Culex quinquefasciatus RepID=B0WMK9_CULQU Length = 474 Score = 162 bits (411), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 99/246 (40%), Positives = 136/246 (55%), Gaps = 29/246 (11%) Query: 12 QSPLALWQAHYVKDKLMASHPGLVVEL------------VP------------MVTRGDV 47 S LAL Q YV L +P +V E+ VP M T GD Sbjct: 166 HSKLALIQTKYVISCLQKLNPDVVYEIRKYFQHVHLCWHVPSYLLAFFLSPDTMTTVGDR 225 Query: 48 ILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDA 107 +L+ L K+G K LF K+LE AL D VHS+KD+P P G+ + + ER+DPRDA Sbjct: 226 VLNKSLPKIGEKSLFTKDLEDALRTGGVDFVVHSLKDLPTALPLGMAIGAVLERDDPRDA 285 Query: 108 FVSNNYD---SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--DNG 162 V N +L LP GS+VGTSSLRR QLA + ++++ +RGN+ TRL+KL D Sbjct: 286 LVLNEAHRGRTLSTLPKGSVVGTSSLRRSAQLARKYENVVVCDIRGNLNTRLAKLDADGS 345 Query: 163 EYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHH 222 ++ IILA AGL R+G +R+ + P L AVGQGA+ +ECR +D ++L+ L H Sbjct: 346 KFAGIILAQAGLVRMGWNARVSQVIEPGEILYAVGQGALAVECRSNDEYILDMLSKLCHL 405 Query: 223 ETALRV 228 ET ++ Sbjct: 406 ETQCKI 411 >UniRef50_B3LB83 Porphobilinogen deaminase, putative n=1 Tax=Plasmodium knowlesi strain H RepID=B3LB83_PLAKH Length = 449 Score = 162 bits (410), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 109/380 (28%), Positives = 176/380 (46%), Gaps = 80/380 (21%) Query: 8 IATRQSPLALWQAHYVKDKLMAS----HPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 I TR SPLA+ Q+ V+ KL A + + + L + T GD ILD + GGKG+F Sbjct: 69 IGTRDSPLAIKQSEKVRTKLEAYFKKVNKNVKITLKSIKTMGDNILDQKVDLFGGKGIFT 128 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL---- 119 KEL+ L++ + I VHS+KDVP+E P+ + L +R+ DAF+S Y +L+ + Sbjct: 129 KELDEELIKGKVHICVHSLKDVPMELPEQVQLSCFLKRDTINDAFLSVKYGTLEDMNKMK 188 Query: 120 -----------PAGS------------------------IVGTSSLRRQCQLAERRPDLI 144 P G +GTSSLRR Q+ + ++ Sbjct: 189 MANKMEEGSYQPKGMSQRVINQNVKRDNYEGDHYDNFIPTIGTSSLRRSSQIKYKYKNVA 248 Query: 145 IRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAAL----------------P 188 ++++RGN+ TR++KL NG+YDAII+A GL+RL + IR + Sbjct: 249 VKNMRGNINTRIAKLCNGQYDAIIIAKCGLERLTTKKGIRNIIGGKNKVTPKNFLINYNN 308 Query: 189 PEISL--------------PAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234 EI+L PA+ QG + + D ++L +N + + ER+ Sbjct: 309 TEINLTSLHIQQINKRTIYPALCQGIIAVSSHKSDKYISDVLKNINDEKAQIMANIERSF 368 Query: 235 NTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 ++EG C +PIG YA++++GEI A++ G + G + ++ + A ++ Sbjct: 369 LYQIEGNCMMPIGGYAKIVNGEIVFNAVINDIHGREKYHVREVGKVESYNEIAVMAATKM 428 Query: 295 LN-------NGAREILAEVY 307 N RE A+ Y Sbjct: 429 KEKIGTHRFNKIREEAAQYY 448 >UniRef50_Q57989 Probable porphobilinogen deaminase n=11 Tax=Methanococcales RepID=HEM3_METJA Length = 292 Score = 159 bits (402), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 95/246 (38%), Positives = 138/246 (56%), Gaps = 5/246 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 ++RI TR S LAL+QA+ V + + + G VE+ + T GD +LD L+ +G G+F K Sbjct: 1 MIRIGTRGSKLALYQANKVAE--LLKNLGYKVEIKIIKTTGDRVLDKKLSDIG-IGVFTK 57 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 EL++A+L N DIAVHS+KD+P + + L + + ER+ D + N + + + Sbjct: 58 ELDLAMLNNEIDIAVHSLKDIPTIWNENLMVGAVLERDSYHDLLIWNKDIDFNE-DSKIV 116 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSS+RR+ L P+ LRGNV TRL KL G YDAI+L+ AG+ RLG+ Sbjct: 117 IGTSSMRRRAFLKFIYPNAKFELLRGNVDTRLRKLKEGLYDAIVLSEAGIIRLGVSLEDF 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 +I LPA QG + + C+ DD + +L +NH T L ER GGC V Sbjct: 177 NYKRLDI-LPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSV 235 Query: 245 PIGSYA 250 P G+ A Sbjct: 236 PFGALA 241 >UniRef50_Q2FTK7 Hydroxymethylbilane synthase n=3 Tax=Methanomicrobiales RepID=Q2FTK7_METHJ Length = 295 Score = 158 bits (400), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 111/288 (38%), Positives = 164/288 (56%), Gaps = 14/288 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LR+ TR S LA QA VK M G+ ELV + T GD PL ++GG+G+FV+ Sbjct: 3 LRVGTRASELAKAQA--VKVCTMLEDLGVDTELVFISTAGDEQTGVPLHEIGGQGVFVRA 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L+ AL++N+ D+AVHSMKD+P E P GL I R+ P D V+++ LD + + + Sbjct: 61 LDDALVQNKIDLAVHSMKDIPAERPYGLVTSAILARDSPCDYIVTDH--ELDEI---TTL 115 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS RR Q P IR LRGNV TRLSKL +GEYDAI+LA AGL+RL + + Sbjct: 116 GTSSTRRTAQCRRNLPWADIRPLRGNVNTRLSKLQSGEYDAIMLAKAGLERLSM-TLDGY 174 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L P + +P+ QG + + R D T ++++ ++ +T + ER + + GGC P Sbjct: 175 QLDPRVHVPSPNQGTIAVVSRTDPDVT-DIISKIDDPKTRMDTLLERRVMEMIGGGCFTP 233 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAP-QDAEQMGISLAE 292 +G Y + + + A V + +G + R ER + DA++ G+ + E Sbjct: 234 LGIYCK----DRLMIAEVLSLEGDRHFRLERLVSDIDDADRFGLEVRE 277 >UniRef50_O26960 Probable porphobilinogen deaminase n=1 Tax=Methanothermobacter thermautotrophicus str. Delta H RepID=HEM3_METTH Length = 289 Score = 158 bits (399), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 106/288 (36%), Positives = 160/288 (55%), Gaps = 10/288 (3%) Query: 10 TRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVA 69 TR S LAL Q ++V + +++ +E + T+GD I D+ L + +GLF +EL++A Sbjct: 5 TRGSRLALVQTNHVIE-MLSEVCKEKIEKKIIKTKGDRIRDSQLYSMDSRGLFTRELDMA 63 Query: 70 LLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSS 129 +L D+AVHS+KDVP + L + + RE P + VS D D LP GS +GTSS Sbjct: 64 VLNEEVDLAVHSLKDVPSDLDPDLAIAAVPPRESPAEVLVSR-LDWED-LPQGSKLGTSS 121 Query: 130 LRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPP 189 LRR+ + + + LRGN+ TR+ K+ +GE A I+A AGLKRLGLE I+ P Sbjct: 122 LRREAFCNHHQKNFKMEPLRGNIDTRIRKVMDGEVHATIMAEAGLKRLGLEEHIKRRFPV 181 Query: 190 EISLPAVGQGAVGIECRLDDSRTRELLAA---LNHHETALRVTAERAMNTRLEGGCQVPI 246 E PA GQGA+ + R D EL+++ + HH + VTAE+ + L GCQ P+ Sbjct: 182 EYFTPAAGQGALAVITRADS----ELISSIGRITHHPSLQEVTAEKTLLRELGAGCQCPL 237 Query: 247 GSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 G ++ L A++ +G + + RG +AE +G A+E+ Sbjct: 238 GVIGRATGNQLTLYAVLLTREGEMLRKVTVRGPLAEAEDIGKKAAKEM 285 >UniRef50_A4YD92 Probable porphobilinogen deaminase n=1 Tax=Metallosphaera sedula DSM 5348 RepID=HEM3_METS5 Length = 290 Score = 158 bits (399), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 113/296 (38%), Positives = 159/296 (53%), Gaps = 14/296 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RIA R S L+L Q V L A G E + + T+ D+ + PL ++G KG+F KE Sbjct: 3 IRIAARGSKLSLKQVEIVTTYLQAK--GYETEFIEIKTKADLFGNKPLHEIG-KGVFEKE 59 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 + A+L+ RADIAVHSMKD+ E P GL L+ +RE+P D VS +L+ LP S + Sbjct: 60 VNEAVLQGRADIAVHSMKDMSSELPPGLELLATPKRENPVDVLVSEL--NLEELPEKSRI 117 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT SLRR L RPDL++ ++RGNV TRL K + EYD IILA AGL+RLG+E + R Sbjct: 118 GTGSLRRANFLKVVRPDLVVENIRGNVDTRLRKYRDHEYDGIILAEAGLRRLGVEVK-RF 176 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L E P QG + + + + L LN T AE+ + GGC P Sbjct: 177 PLDVESFTPEPNQGIIAV---VGSPKFLGLFQELNDTGTMKEALAEKETVKVVGGGCHSP 233 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQ--IIRGERRGAPQDA-EQMGISLAEELLNNG 298 +G L D L + +G + ++ R +PQ A Q+G +L + + + G Sbjct: 234 LGVLFRLEDD--VLHGIASYSNGVKRVTVKLSTRESPQIAGNQLGKALVKAMKDEG 287 >UniRef50_A1DGB8 Porphobilinogen deaminase n=1 Tax=Neosartorya fischeri NRRL 181 RepID=A1DGB8_NEOFI Length = 363 Score = 156 bits (395), Expect = 8e-37, Method: Compositional matrix adjust. Identities = 120/344 (34%), Positives = 166/344 (48%), Gaps = 39/344 (11%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMAS-HPGLVVELVPMVTRGDVILDTPLAKVG---- 57 + V+ R+S LAL Q +V KL + P ++ GD P A + Sbjct: 20 EEVVIFGCRKSELALVQTRWVTSKLGQTLDPSPTFQIATGSAVGDADKQAPFAVLSKLTG 79 Query: 58 ----GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN- 112 GK L+ ELE+ L+ + VHS+KD+P P L + ERED DA + Sbjct: 80 GSDIGKSLWTNELELDLVAGKVHCLVHSLKDMPTTLPPHCLLGAVPEREDCSDAVCMRSD 139 Query: 113 --YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAII 168 + S+D LP GSIVGTSS RR+ + P L + RGNV TRL+KLD + + I+ Sbjct: 140 LKFTSIDQLPPGSIVGTSSSRRKALVRRNWPHLEVVECRGNVDTRLAKLDAPSSRFSCIL 199 Query: 169 LAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRV 228 LA AGL RLGL RI L I AVGQGA+G+E D EL+ ++H + R Sbjct: 200 LATAGLLRLGLGHRITHRLDDSIFPYAVGQGALGLEVSTDRPDILELVRHVDHKPSRWRG 259 Query: 229 TAERAMNTRLEGGCQVPIGSYAEL----------------------IDGEIWLRALVGAP 266 AERAM L+GGC PIG + L G + LRA+V Sbjct: 260 IAERAMLRSLQGGCSSPIGVQSSLEPLGKEENGSTEDDSQRGRDSSSGGNLSLRAMVLHI 319 Query: 267 DGSQIIRGERRG---APQDAEQMGISLAEELLNNGAREILAEVY 307 +G+ I E ++AE +G+S+A LL GAR ++ + + Sbjct: 320 EGTSEIVAEDMATVRCDEEAELLGVSVANMLLAKGARGLMPKQF 363 >UniRef50_D1B7N1 Porphobilinogen deaminase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B7N1_THEAS Length = 307 Score = 156 bits (395), Expect = 8e-37, Method: Compositional matrix adjust. Identities = 120/304 (39%), Positives = 163/304 (53%), Gaps = 18/304 (5%) Query: 10 TRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVA 69 TR SPLA+ QA KD++ + G V L+ + T GD LA GG G FVK LE Sbjct: 8 TRSSPLAMAQARMWKDRIESL--GHSVRLLDVSTHGDRDRRRHLACFGGFGAFVKALEDR 65 Query: 70 LLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSS 129 LL + AVHS+KDVP P GL + + ER D V+ SL+ LP+G+++GTSS Sbjct: 66 LLSGQGHGAVHSLKDVPSVQPDGLVIAGVLERGPRGDVLVTREGLSLEELPSGAVIGTSS 125 Query: 130 LRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPP 189 +RR Q+ R DL + RGNV +RL KL+ G + I+LA AGL+RLG+ R A P Sbjct: 126 IRRAAQVRMLRGDLNVECCRGNVHSRLRKLEQGLFHGIVLARAGLERLGI--RAPMAELP 183 Query: 190 EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSY 249 I+ P GQGAV +E R + S L A L H T L V AER+ GC P+ + Sbjct: 184 FITSP--GQGAVALEAR-EGSELHLLGARLTHRSTWLEVLAERSFLKAFGMGCSAPVAAS 240 Query: 250 AELIDGEIWLRALVGAPDGSQIIRGERRGAP---QDAEQMG------ISLAEELLNNG-- 298 A + + L+ V +P+G+ E P +DA +G IS + E+L+ G Sbjct: 241 AVMDRDTLTLKVQVLSPNGTSAAEAEVSCVPWGEEDAYALGEAAFREISGSPEVLSAGSA 300 Query: 299 AREI 302 ARE+ Sbjct: 301 AREV 304 >UniRef50_A2SQU4 Uroporphyrin-III C-methyltransferase n=11 Tax=Euryarchaeota RepID=A2SQU4_METLZ Length = 542 Score = 154 bits (390), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 102/249 (40%), Positives = 141/249 (56%), Gaps = 12/249 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LAL Q V L + G+ E V + T GD + D L ++GG G+FV+E Sbjct: 4 IRIGTRGSKLALAQTKKVIGLL--AENGIDAEYVIIKTTGDKVTDRGLHQIGGFGMFVRE 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L+ A+L D AVHSMKD+P E P+GL V + +R+ P D V N ++ L ++ Sbjct: 62 LDNAILRGEIDCAVHSMKDIPAERPKGLLTVAVLKRDPPYDFLVMNG--KVEDL---MVI 116 Query: 126 GTSSLRRQCQL---AERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 GTSSLRR+ QL P + + LRGN+ TRL KLD+G YD I++A AGL RL + R Sbjct: 117 GTSSLRRKAQLLRYFHNCPAVRVEMLRGNLDTRLGKLDDGLYDGIMVAEAGLMRLDYK-R 175 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 L P++ +PA QG + I R D R A LN ++AL ER + ++ GGC Sbjct: 176 NGVRLSPDMFVPAANQGTIAIVSR-DTPELRAAFAPLNDPQSALDCAIERIVMEQVGGGC 234 Query: 243 QVPIGSYAE 251 P+G + E Sbjct: 235 FTPMGIFCE 243 >UniRef50_Q8I5V3 Porphobilinogen deaminase n=6 Tax=Plasmodium RepID=Q8I5V3_PLAF7 Length = 435 Score = 154 bits (389), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 92/341 (26%), Positives = 160/341 (46%), Gaps = 61/341 (17%) Query: 8 IATRQSPLALWQAHYVKDKLMAS----HPGLVVELVPMVTRGDVILDTP-LAKVGGKGLF 62 I TR SPLAL Q+ V+ K+M+ + + V + T GD ILD+ + GGKG+F Sbjct: 64 IGTRDSPLALKQSEKVRKKIMSYFKKMNKNINVTFKYIKTTGDNILDSKSVGLYGGKGIF 123 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 KEL+ L+ D+ VHS+KDVP+ P + L +R+ DAF+S Y S++ + Sbjct: 124 TKELDEQLINGNVDLCVHSLKDVPILLPNNIELSCFLKRDTINDAFLSIKYKSINDMNTV 183 Query: 123 S------------------------IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSK 158 +GTSSLRR+ Q+ R ++ + ++RGN+ TR+ K Sbjct: 184 KSVSKTEDIHHINKKDSDHNNDTLCTIGTSSLRRRSQIKNRYKNIYVNNIRGNINTRIEK 243 Query: 159 LDNGEYDAIILAVAGLKRLGLESRIR--------------------------------AA 186 L NGE DA+I+A+ G++RL ++ ++ Sbjct: 244 LYNGEVDALIIAMCGIERLIKKANLKHLLKNKEQKNICQPFLLKCNNKKCIDLCHVNIQK 303 Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246 L + PA+GQG + + + LL +N+ ++ + ER+ ++G C +PI Sbjct: 304 LNKNLIYPALGQGIIAVTSHKKNYFISSLLKNINNKKSEMMAQIERSFLYHIDGNCMMPI 363 Query: 247 GSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMG 287 G Y + + +I+L ++ G + ++ + +++G Sbjct: 364 GGYTNMRNEDIYLHVIINDIHGYNKYQVTQKDTLYNYKEIG 404 >UniRef50_Q2NEP4 HemC n=4 Tax=Methanobacteriaceae RepID=Q2NEP4_METST Length = 290 Score = 153 bits (387), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 95/294 (32%), Positives = 156/294 (53%), Gaps = 12/294 (4%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67 + TR S LA Q V L + + + T GD I ++ L + KG+F KEL+ Sbjct: 3 VGTRGSKLATTQTKTVVKALEEITGEEIETKI-IKTTGDKIKNSQLYNIDAKGIFTKELD 61 Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127 AL++ D AVHS KD+P E L + I +RE + +SN S D LP + +GT Sbjct: 62 TALIDGSIDFAVHSFKDLPSELNDQLTITAIPQREAINEVLISNY--SWDELPENATLGT 119 Query: 128 SSLRRQ--CQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 SS+RR+ C+L ++ + + +RGN+ TR+ K++ GEYDA I+A+AG+ RLGL+ I+ Sbjct: 120 SSVRREAFCKLHGKK--IQTKPIRGNIDTRIRKVEEGEYDATIMALAGINRLGLQEHIKE 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 + P GQGA+ + DS ++++ LNH ++ + E+A+ + GCQ P Sbjct: 178 VFDEQYITPPAGQGALAVMTH-KDSEYNDVISKLNHEDSRIEAMTEKAILETIGVGCQWP 236 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQII----RGERRGAPQDAEQMGISLAEELL 295 IG +++ I + + +P+G + ++ A A+ +G L E+ L Sbjct: 237 IGIVSKVDGNNINIHCKLLSPEGKLLADVNKTTDKNNAINTAKVIGTKLREDTL 290 >UniRef50_D0J8N1 Porphobilinogen deaminase n=2 Tax=Blattabacterium RepID=D0J8N1_BLASP Length = 310 Score = 153 bits (386), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 101/307 (32%), Positives = 154/307 (50%), Gaps = 11/307 (3%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 ++ ++RI TR SPLA+ QA V+ L G L + + GD+I + PL K G+ Sbjct: 1 MNKIIRIGTRNSPLAISQAIEVQKVL--HRLGYCSHLFFIKSEGDLIQNIPLYKFKKVGI 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDSLDA 118 F + L LL + D+AVHS+KDVP P+ + L +R D + S+N+ Sbjct: 59 FTRNLTDVLLSGKIDMAVHSLKDVPTSLPEKIVLSAYLKRGSFSDLLIYQGSSNFLLNSK 118 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 + A ++ T SLRR+ R P I LRGN+ TRL KL N + I A GL+RLG Sbjct: 119 IEA--VIATGSLRRRAFWKNRYPHHTIVDLRGNINTRLKKLYNNSWKGAIFAKVGLERLG 176 Query: 179 LESRIRAALPP--EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236 L + + + +P+ GQG + + R D+ L L+ T L ER Sbjct: 177 LLNDLEGFNFKVLDWMIPSPGQGIIVVSTRKDNEWIHYLTKELDDRNTRLSANIERQFLK 236 Query: 237 RLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 L GGC PIG++A + + I+ ++ + DG Q IR ++ G + +G A+E+L Sbjct: 237 TLGGGCVTPIGAHAIIKNKIIYFTGILFSLDGMQKIRKKKIGTNYNV--IGYQCAKEILE 294 Query: 297 NGAREIL 303 G ++IL Sbjct: 295 EGGKKIL 301 >UniRef50_B5GJG2 Porphobilinogen deaminase n=3 Tax=Streptomyces RepID=B5GJG2_9ACTO Length = 335 Score = 153 bits (386), Expect = 9e-36, Method: Compositional matrix adjust. Identities = 114/304 (37%), Positives = 153/304 (50%), Gaps = 12/304 (3%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTP----LAKVGGKGLFV 63 + +R S LA Q + ++ PG+ + GD TP + + G F Sbjct: 35 VGSRGSALARAQVREMVERWEREVPGVRFVRRVITEAGDADRSTPTVAGVTRRAGVSAFS 94 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLV-TICEREDPRDAFVSNNYDSLDALPAG 122 E AL+ D+ VH +KD+P G L+ T RED RDA +L LP G Sbjct: 95 SRQEAALVRREVDVVVHCLKDLPTTPAPGTALLRTPGPREDARDALCGA---TLAGLPRG 151 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 + VGT S RR QL RPDL + +RGNV RL++L DA++LA AGL RLGL Sbjct: 152 ARVGTGSTRRVAQLLALRPDLEVIPVRGNVPARLARLRT--LDAVVLAAAGLHRLGLTEE 209 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 I L PE PA GQGA+ I+ R + S LLAA T V AER + L GGC Sbjct: 210 ITEYLDPEAYPPAPGQGALAIQVR-EGSGAARLLAASGDPATDTEVRAERVLLAELHGGC 268 Query: 243 QVPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 VP+G++ G + L A V APDG + I +G + +++ +++AE LL GA Sbjct: 269 SVPLGTWTSRPSPGTLRLHAAVTAPDGGRQITATAQGPASEPDKLALTVAERLLAGGAAR 328 Query: 302 ILAE 305 ILAE Sbjct: 329 ILAE 332 >UniRef50_C0W553 Porphobilinogen deaminase n=2 Tax=Actinomycetales RepID=C0W553_9ACTO Length = 402 Score = 151 bits (381), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 135/377 (35%), Positives = 183/377 (48%), Gaps = 81/377 (21%) Query: 4 NVLRIATRQSPLALWQAHYVKDKL--MASHPG--LVVELVPMVTRGDVILDTPLAKVGGK 59 + +R+ TR S LAL Q+ V L A+ G L VELVP+ TRGDV T L+++GG Sbjct: 2 STVRLGTRGSALALTQSGLVARMLEQAAALAGQELHVELVPVRTRGDVD-PTALSQLGGV 60 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD-SLDA 118 G+F L ALL D+AVHS KD+P GL + + REDPRD + L Sbjct: 61 GVFATALREALLAGECDLAVHSYKDLPTAAVPGLRIAAVPAREDPRDVLCTRAATLGLHD 120 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG--------------EY 164 LPAG+ VGT S RR QL +RPDL I +RGNV TRL+++ + Sbjct: 121 LPAGARVGTGSPRRSAQLLAQRPDLTIVPIRGNVPTRLARVVGSVVSADGPMGATAEPDL 180 Query: 165 DAIILAVAGLKRLGLE--------------SRIR---------AALPPEIS----LPAVG 197 DA ILA++G++RLGLE S++ AA P + LPA Sbjct: 181 DAAILALSGMRRLGLEDYASQPLAARCGARSQVEVQGIPDGGSAAGSPATTEPWMLPAAA 240 Query: 198 QGAVGIECRLDDSRTREL------LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAE 251 QGA+ +E R D + EL LA ++ T AER++ L GC P+G+ A Sbjct: 241 QGALAVETR--DRVSCELPVLTVALALVDDPVTRACADAERSLMRCLAAGCAAPVGALAR 298 Query: 252 LID--GE------------------------IWLRALVGAPDGSQIIRGERRGAPQDAEQ 285 +D GE I L ALV + DG+Q+ R G ++AE Sbjct: 299 PLDVAGEPAAGRDLPTEPGTALEPGPDQAPAICLEALVASLDGTQLRRASATGTLEEAED 358 Query: 286 MGISLAEELLNNGAREI 302 +G +AE LL +GA +I Sbjct: 359 LGRCVAERLLADGAAQI 375 >UniRef50_C4JRY9 Porphobilinogen deaminase n=1 Tax=Uncinocarpus reesii 1704 RepID=C4JRY9_UNCRE Length = 287 Score = 151 bits (381), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 107/314 (34%), Positives = 156/314 (49%), Gaps = 58/314 (18%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67 I TR+SPLAL Q V+ L ++P Sbjct: 11 IGTRKSPLALVQTDLVRRALQTAYPN---------------------------------- 36 Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALPAGSI 124 D+ VH VP + P L + RE+PRD V + +L LPAGS+ Sbjct: 37 -------CDLKVHG--HVPTQIPDACVLGAMMPRENPRDVLVIKKGLPWMTLAELPAGSV 87 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLKRLGLESR 182 VGTSS+RR QLA P L+++ +RGN+ TRL+KLD +G + +I+A AGL R G E+R Sbjct: 88 VGTSSVRRTAQLARHYPHLVVQDIRGNIDTRLAKLDAEDGPFTCLIMAAAGLLRTGHENR 147 Query: 183 IRAALPPEIS--LPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 + L + L AVGQGA+GIE R DD ++++ + T AER + +EG Sbjct: 148 VTQYLDSKNGKMLHAVGQGALGIEVRTDDEVMKDMVNKIGDMPTTYACMAERNLLRTVEG 207 Query: 241 GCQVPIGSYAELIDGE-----IWLRALVGAPDGSQIIRGERRG---APQDAEQMGISLAE 292 GC P+G E I + + LRA+V + DG + + E+ G + ++AE G +A Sbjct: 208 GCSAPLGVETEWIQDDNGKSLLRLRAIVVSVDGKEAVELEKDGDVESIEEAEAFGKQVAL 267 Query: 293 ELLNNGAREILAEV 306 EL++ GA +IL E+ Sbjct: 268 ELIDKGAGKILEEI 281 >UniRef50_B6JII8 Porphobilinogen deaminase n=11 Tax=Bradyrhizobiaceae RepID=B6JII8_OLICO Length = 338 Score = 150 bits (379), Expect = 6e-35, Method: Compositional matrix adjust. Identities = 112/322 (34%), Positives = 161/322 (50%), Gaps = 18/322 (5%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 + D +RI TR+S +AL Q + +L A+ P L VE+V T GD L +GGKG Sbjct: 9 VTDKAMRIGTRKSVMALAQTSEIARQLTAADPALDVEIVKFETTGDQDQTGKLLDLGGKG 68 Query: 61 -LFVKELEVALLENRADIAVHSMKDVP-VEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118 FV ++ A+ E R + A+HS+KD+P E GL + R+ P DA V + +L Sbjct: 69 GAFVAQIRDAVREGRLEAAMHSLKDMPGNEDTPGLVIGATLTRDPPTDALVVRHGVTLAD 128 Query: 119 L----PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY---------- 164 L G +GT+++RR + P+ I RG TR+ KLDNGE Sbjct: 129 LRRTGGKGFKIGTNAVRRAAYVRRLFPECEIIHFRGAADTRIRKLDNGEKQRLPEGGEVG 188 Query: 165 --DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHH 222 DA+++A AGL+R+G RI P+ LPAVGQG V +EC D T LA ++ Sbjct: 189 PADALVMAQAGLERVGCADRIAHCFSPDEILPAVGQGIVAVECAASDWCTLARLAQIDDP 248 Query: 223 ETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD 282 + AER + L G C PI YA + ++ L+A V I RRG Sbjct: 249 VSRCCAAAEREVLWVLNGHCNSPIAGYAIVEGDDVLLKAAVLDEANDHFIEVTRRGPASR 308 Query: 283 AEQMGISLAEELLNNGAREILA 304 ++G ++A ELL GA +++A Sbjct: 309 PRELGRAVAFELLAKGAADVIA 330 >UniRef50_D1JID7 Porphobilinogen deaminase n=1 Tax=uncultured archaeon RepID=D1JID7_9ARCH Length = 290 Score = 149 bits (376), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 97/264 (36%), Positives = 148/264 (56%), Gaps = 10/264 (3%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67 + TR S LAL Q V ++L S G+ E+ + + GDV+ D L ++ G+FVK+L+ Sbjct: 3 VGTRGSNLALVQTKKVCERL--SELGVECEIKTVQSLGDVMTDRGLYEMPTIGVFVKKLD 60 Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127 + LL+ + DIAVHSMKD+P E + L + R+ P DA VS LD +P G+++GT Sbjct: 61 MMLLDAKIDIAVHSMKDMPSEREEELDTSAVLPRDSPYDALVSRY--RLDDMPEGAVIGT 118 Query: 128 SSLRRQCQL----AERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 SS+RR+ Q ER + I+ +RGNV TR++K GEYD++ILA AG +RL L+ Sbjct: 119 SSVRRRYQFLNYVGERGVKVTIKDIRGNVDTRIAKFRRGEYDSVILAEAGFERLKLDIEY 178 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 L + +P+ QG + + R S+ E+L ++ ET + E + + GGC Sbjct: 179 E-RLDRDPFVPSPRQGIIAVVAR-RGSKESEILKQIDDSETRIEAEVEEEVLKVIGGGCS 236 Query: 244 VPIGSYAELIDGEIWLRALVGAPD 267 +P+G +A G + L V A D Sbjct: 237 LPVGVHATAKGGSVELAVYVAASD 260 >UniRef50_A5K0J5 Porphobilinogen deaminase, putative n=1 Tax=Plasmodium vivax RepID=A5K0J5_PLAVI Length = 341 Score = 148 bits (373), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 92/319 (28%), Positives = 147/319 (46%), Gaps = 69/319 (21%) Query: 45 GDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDP 104 GD ILD + GGKG+F KEL+ L++ I VHS+KDVP+E P+ + L +R+ Sbjct: 2 GDHILDKKVGLFGGKGIFTKELDEQLIKKNVHICVHSLKDVPMELPEHVQLSCFLKRDTI 61 Query: 105 RDAFVSNNYDSLDAL---------------PAGSI------------------------V 125 DAF+S Y +L+ + G+I + Sbjct: 62 NDAFLSVKYATLEDMNKRKMANKVEEESDQEKGTIQQMTNQGLKRDNCEGDKCTNFIPTI 121 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR- 184 GTSSLRR Q+ ++ ++++RGN+ TR++KL NG+YDAII+A GL+RL + +R Sbjct: 122 GTSSLRRSSQIKYTYKNVAVKNVRGNINTRIAKLCNGQYDAIIIAKCGLERLLTKKVVRN 181 Query: 185 -----AALPPEISL------------------------PAVGQGAVGIECRLDDSRTREL 215 +PPE L PA+ QG + + +D T + Sbjct: 182 IIRGKGKVPPEKFLLNHNDMETNLRLLRIQQINRRTIYPALCQGIIAVTSHKNDVDTSNI 241 Query: 216 LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE 275 L +N + + ER+ ++EG C +PIG YA+++ GEI A++ G + Sbjct: 242 LKNINDEKAQIMANVERSFLYQIEGNCMMPIGGYAQIVGGEIVFNAVINDTHGREKYHVR 301 Query: 276 RRGAPQDAEQMGISLAEEL 294 G Q+ + A ++ Sbjct: 302 EVGTVQNCNNIAAMAATKM 320 >UniRef50_Q4E9D5 Porphobilinogen deaminase (Fragment) n=1 Tax=Wolbachia endosymbiont of Drosophila ananassae RepID=Q4E9D5_9RICK Length = 199 Score = 147 bits (370), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 81/196 (41%), Positives = 119/196 (60%), Gaps = 6/196 (3%) Query: 100 EREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL 159 ER P DAF+S+ ++SL++LP + + TS++RR+ QL RPDL I LRGNV TRL Sbjct: 4 ERLSPCDAFISHKHNSLESLPQQATIATSAIRRKVQLLNFRPDLNIVPLRGNVTTRL--- 60 Query: 160 DNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAAL 219 N +D IILA AGL RL I LPP++ L AVGQGA+ I+CR +D + +LL + Sbjct: 61 QNQSFDGIILAEAGLIRLEKHHLITEVLPPKVMLSAVGQGAICIQCRRNDVKIIDLLEKI 120 Query: 220 NHHETALRVTAERAMNTRLEGGCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRG 278 N++ + + V +ER+ + G C P+ + AE + + ++LR ++ DG I ER Sbjct: 121 NNNMSFIGVKSERSFMKTVNGSCFTPLAALAEYVSENMLYLRCMLA--DGKNIYFTERTS 178 Query: 279 APQDAEQMGISLAEEL 294 +DAE+MG+ EL Sbjct: 179 FIEDAEKMGMDAGLEL 194 >UniRef50_C3MZR8 Probable porphobilinogen deaminase n=11 Tax=Sulfolobus RepID=HEM3_SULIA Length = 293 Score = 145 bits (366), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 98/294 (33%), Positives = 155/294 (52%), Gaps = 11/294 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RIA R S L+ Q + +KL G+ E++ + T+ D+ PL+K+G KG+F KE Sbjct: 3 IRIAARGSKLSRIQVDMLGEKL--KKIGIEYEIIDIKTKADLFSTEPLSKLG-KGVFEKE 59 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 + A+LE +ADIAVHSMKD+ E L + + ER+ P D ++ +LD L + + Sbjct: 60 VNEAVLEGKADIAVHSMKDILSEINPSLEIFAVLERDPPYDILIAEK--NLDKLDSNITI 117 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR+ L +P++ + +RGNV TR+ K + EY +ILA A LKRL + Sbjct: 118 GTSSIRRKNFLKYIKPEINTKDIRGNVDTRIRKYLSKEYQGLILAEASLKRLNMTMNYHR 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 + + P QG + R D + +E+ +NH +T AERA+ + + GGC P Sbjct: 178 LNVYDFT-PEANQGIIVALGRKKDEKIKEIFKEINHKDTLDEALAERAVISLVGGGCHSP 236 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRG--ERRGAPQD-AEQMGISLAEELLN 296 IG + E + + DG + I + G P ++G+ L +E+ N Sbjct: 237 IGVLFKKEGKEFY--GIASYSDGKKKITVSISKPGDPYTIGSELGLLLKKEMKN 288 >UniRef50_UPI000038E213 porphobilinogen deaminase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E213 Length = 285 Score = 142 bits (359), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 91/253 (35%), Positives = 136/253 (53%), Gaps = 8/253 (3%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67 I TR S LAL QA+ VKD L + G V + + GD + PL ++ G+FV EL Sbjct: 5 IGTRNSKLALIQANSVKDALESR--GYEVNIKSYTSAGDSNKNIPLYRMSSTGVFVDELN 62 Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127 +L+ D+AVHS KD+P +GL + + R+D RD +S L+ + AGS++GT Sbjct: 63 ERVLKGEIDLAVHSAKDIPSNIQKGLEITAVTGRDDFRDVLISRT--PLEEMTAGSVIGT 120 Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAAL 187 SS+RR Q P++ + +RGN+ TR+SK +Y II+A+A KR+ L+ L Sbjct: 121 SSMRRIRQAMTVNPEITVSDIRGNIDTRISKYTEKKYTGIIIAMAAYKRMKLDIE-HFIL 179 Query: 188 PPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIG 247 E LPA QG + I + +S + +N ET + ER + T L GC +P+G Sbjct: 180 SEEQFLPAPNQGIIAIVGK-SNSPASIISGEINDRETYRDMKNERFIATSLNLGCSMPVG 238 Query: 248 SYAELIDGEIWLR 260 ++ DG+I R Sbjct: 239 ILSK--DGKIKTR 249 >UniRef50_Q9Y9J0 Probable porphobilinogen deaminase n=1 Tax=Aeropyrum pernix RepID=HEM3_AERPE Length = 307 Score = 142 bits (357), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 108/295 (36%), Positives = 158/295 (53%), Gaps = 10/295 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVV--ELVPMVTRGDVILDTPLAKVGGKGLFV 63 +R+A R S L+L Q ++L + + G+ + E+V + + GDV D PL +G G+F Sbjct: 3 VRVAARGSRLSLLQVEQALEEL-SRYAGVSMHWEVVRVKSAGDVWSDRPLESIGVVGVFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQG-LGLVTICEREDPRDAFVSNNYDS-LDALPA 121 +E++ A+ ADIAVHS+KD+P G L +V I R RDA +S ++ L Sbjct: 62 REVDRAVASGAADIAVHSLKDMPTSGYGGPLKIVYIASRPSARDALISRQGPGRVEDLEP 121 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 GS +GTSS RR+ P + + +LRGN+ TRL KL G YDAII + AGL RLG++ Sbjct: 122 GSTLGTSSARRRALSLHYNPRIRVENLRGNLDTRLRKLREGLYDAIIASEAGLIRLGVDV 181 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 L P PA GQG V + R+ S ++L L+ AER + G Sbjct: 182 EY-TPLDPSYFPPAPGQGFVAVVARV-GSNVEKMLRDLDKPPWWHVAWAERGVLEGARAG 239 Query: 242 CQVPIGSYAELIDGEIWLRALVGA--PDGSQIIRGERRGAPQDAEQMGISLAEEL 294 C+ P+ +YAE + G +R A PDGS+ G ++A ++G+SL EEL Sbjct: 240 CRTPVAAYAEPL-GRSMVRVTAAALSPDGSRAYWARAEGRIEEARRIGVSLGEEL 293 >UniRef50_Q86ET2 Clone ZZD1450 mRNA sequence n=3 Tax=Schistosoma japonicum RepID=Q86ET2_SCHJA Length = 277 Score = 137 bits (345), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 86/208 (41%), Positives = 112/208 (53%), Gaps = 21/208 (10%) Query: 1 MLD----NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKV 56 MLD + +R+ +R+S LAL Q L P ++ E+V + T GD ILD PL+K+ Sbjct: 1 MLDASSQHAVRVGSRRSNLALLQTEMAISLLKVQKPHIMFEVVEIATVGDEILDVPLSKI 60 Query: 57 GGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNY 113 G K LF KELE +LL D+ VHS+KDVP P GL L + R P D + N Sbjct: 61 GDKSLFTKELEKSLLVGEVDLVVHSLKDVPSVLPTGLVLGCVFGRSSPEDVVLMAPHNRG 120 Query: 114 DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG----------- 162 L LP G+ VGTSS+RR L + P L S+RGN+ TRL+KLD Sbjct: 121 MKLSDLPVGATVGTSSIRRVATLIRKYPHLKFISIRGNLNTRLAKLDTPSNLQKQCCTGN 180 Query: 163 ---EYDAIILAVAGLKRLGLESRIRAAL 187 YDA+ILA AG++R+G RI L Sbjct: 181 QSLSYDALILAKAGVERMGWVDRIDQVL 208 >UniRef50_Q97B26 Probable porphobilinogen deaminase n=2 Tax=Thermoplasma RepID=HEM3_THEVO Length = 297 Score = 135 bits (340), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 86/242 (35%), Positives = 132/242 (54%), Gaps = 6/242 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 ++I TR S LA+ QA+ V L A G+ E+V + GD+ P+ +G G+FV++ Sbjct: 3 IKIGTRPSNLAVAQANMVASSLEA--IGIDTEIVKHRSAGDIDTKNPIYSIGKTGVFVQD 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L +L D+AVHS KD+P E L + +R DA VS YD L +LP + V Sbjct: 61 LNNMILRGEIDVAVHSAKDIPSEIENRLTIAATLKRGSFNDALVSK-YD-LRSLPISAKV 118 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR QL R DL ++RGN+ TR++K+ DAI++A A ++RLGL + Sbjct: 119 GTSSIRRIFQLKYARQDLKFENIRGNIETRIAKMSELGLDAIVMAEAAIQRLGLNVEY-S 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L +PA QG + + + + R++L +N T + ER++ +L+ GC P Sbjct: 178 KLDENKFVPAPNQGIIAVVSK-KEGTVRKILEEINDENTFEEMQIERSVVQQLKLGCSTP 236 Query: 246 IG 247 +G Sbjct: 237 VG 238 >UniRef50_Q0RS16 Porphobilinogen deaminase 1 (PBG 1) (Hydroxymethylbilane synthase 1) (HMBS 1) (Pre-uroporphyrinogen synthase 1) n=2 Tax=Frankia RepID=Q0RS16_FRAAA Length = 402 Score = 133 bits (335), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 85/195 (43%), Positives = 113/195 (57%), Gaps = 6/195 (3%) Query: 13 SPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTP--LAKVGGKGLFVKELEVAL 70 S LAL Q+ + +L G V+LVP+VT GD +P ++++GG G+FV L AL Sbjct: 36 SALALTQSGMIAAQLR-ERVGCAVDLVPIVTAGD---RSPAEISQIGGTGVFVSALRDAL 91 Query: 71 LENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSL 130 L D+AVHS+KD+P P GL L + RED RD VS + L AL G+ V T + Sbjct: 92 LAGEIDLAVHSLKDLPTATPPGLVLAAVPTREDTRDVLVSPSGRGLAALGPGARVATGAP 151 Query: 131 RRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPE 190 RR QL + ++RGNV TRL K +GE DA++LA AGL RL + L PE Sbjct: 152 RRAAQLRALGLGFDVVAIRGNVDTRLKKAIDGEVDAVVLAYAGLARLDRLDAVTEILDPE 211 Query: 191 ISLPAVGQGAVGIEC 205 + LPA GQGA+ +EC Sbjct: 212 VMLPAPGQGALAVEC 226 >UniRef50_Q83H95 Porphobilinogen deaminase n=2 Tax=Tropheryma whipplei RepID=Q83H95_TROW8 Length = 321 Score = 131 bits (329), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 114/336 (33%), Positives = 159/336 (47%), Gaps = 54/336 (16%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTP--LAKVGG----K 59 LRI TR S LA Q V+ + R +LDT L + G Sbjct: 4 LRIGTRSSLLATAQTAQVQKTM----------------RDVFLLDTQQVLIQTGSVRRRD 47 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 G FV L ALLE D+AVHS+KD+P+ +G + + REDP D + +L L Sbjct: 48 GSFVAALRTALLEGECDLAVHSLKDIPIAPHEGTLITAVLPREDPCDVLCARKDLTLTTL 107 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P+G+ VGT+S RR+ Q+ RPDL + SLRGN+ RL LD DAI+L+ AGLKR+ Sbjct: 108 PSGAKVGTASARRRAQILNFRPDLDVVSLRGNIDKRLIHLDT--LDAIVLSAAGLKRIDR 165 Query: 180 ESRIRAALPPEISLPAVGQGAVGIE-CR--LDDSRTR-ELLAALNHHETALRVTAERAMN 235 E I + A GQG++ IE CR LDD + R + L++ + TAER + Sbjct: 166 EDAITESFDIHDWPTAAGQGSLAIEVCRAQLDDPQNRVAVTYRLDNPMARVTTTAERGVL 225 Query: 236 TRLEGGCQVPIGSYAELI--DGEIWLRALVGAPDGS---QIIRGERR------------- 277 + L+ C PI +A D + L A V + DG + IR R Sbjct: 226 SLLQADCFSPIAVHAVYTANDKSLRLHAKVFSRDGKIFCESIRFARLVKQLTDTNQNHTK 285 Query: 278 --------GAPQDAEQMGISLAEELLNNGAREILAE 305 A + A + ++ +ELL+ AREIL + Sbjct: 286 NSGSDDIGNALEVAMTLAKTVVDELLSKNAREILKQ 321 >UniRef50_B6YQR9 Hydroxymethylbilane synthase/uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YQR9_AZOPC Length = 682 Score = 130 bits (328), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 81/223 (36%), Positives = 122/223 (54%), Gaps = 20/223 (8%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG------- 58 LR+ +R SPL+L Q ++ + P + +L+ + + GD L + Sbjct: 11 LRVISRNSPLSLLQVK----EVFSFFPNIDYQLITIESFGDKNKHVALFDISNVSSFFLE 66 Query: 59 ----KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD 114 F +EL+ AL+ N+ADIAVHS KD+P P L L + + D D+ +S N Sbjct: 67 EESISDFFTRELDEALIYNKADIAVHSAKDLPYPLPYDLELFALFQAMDKSDSLISRNNL 126 Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174 +L+ LP + VGTSS +R+ +L + RPDL + S+RGN+ R++K+DNG DA+I+A L Sbjct: 127 TLEQLPPRARVGTSSQKRKTELLKIRPDLEVVSIRGNIEERIAKMDNGFIDALIVATCAL 186 Query: 175 KRLGLESRIRAALPPEI-SLPAVGQGAVGIECRLDDSRTRELL 216 RLG+E+RI LP E SL QG + I R +D + L Sbjct: 187 IRLGMEARIACILPFETHSL----QGNLAIVGRKNDKNVKNLF 225 >UniRef50_B4UXX3 Porphobilinogen deaminase 2 (Fragment) n=1 Tax=Streptomyces sp. Mg1 RepID=B4UXX3_9ACTO Length = 231 Score = 130 bits (326), Expect = 9e-29, Method: Compositional matrix adjust. Identities = 88/224 (39%), Positives = 119/224 (53%), Gaps = 8/224 (3%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +R+ TR SP+AL Q D A +P +V+++V +V+ GD PL+ +GGKG F Sbjct: 9 TTVRLGTRPSPMALEQTGRFADVFRARYPQVVLDIVEIVSEGDR-HRGPLSTIGGKGAFT 67 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLV--TICEREDPRDAFV---SNNYDSLDA 118 + + LL+ R + KDVP + G+V + RED RDA V + +L Sbjct: 68 RNADRYLLDGRVQATIACAKDVPGPHDRSPGIVIAAVLPREDTRDALVLPTGHPVTTLAE 127 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY--DAIILAVAGLKR 176 LP G+ VGTS+ RR L P L+ +RGN +RL LD G D +I A+AGL+R Sbjct: 128 LPPGTRVGTSAPRRSALLKALHPTLVQVPIRGNADSRLRALDAGRLGADVMIAALAGLRR 187 Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALN 220 LG E R L P + LPA G G V +E R DD T LLA L Sbjct: 188 LGHEDRASEILDPAVWLPAAGAGTVIVEHRSDDPATGWLLAPLT 231 >UniRef50_B1ZV87 Porphobilinogen deaminase n=2 Tax=Opitutaceae RepID=B1ZV87_OPITP Length = 284 Score = 129 bits (325), Expect = 9e-29, Method: Compositional matrix adjust. Identities = 96/248 (38%), Positives = 126/248 (50%), Gaps = 13/248 (5%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L +ATR+SPLAL Q V L A G+ EL+ +VT GD + L + GGKGLF E Sbjct: 4 LILATRKSPLALRQTEMVAAHLEA-RLGVQTELLKLVTTGDRQTEWSLEQKGGKGLFTSE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE AL AD+AVHS KD+P + L + R D RD V + A + Sbjct: 63 LENALRRGEADLAVHSTKDLPGDMAAELAVAGYLPRADARDVLVLRA-----GVAAPKSL 117 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESRIR 184 T S RR+ Q+A+ P + +RGNV TRL K+ G D +LA AGL RLG+ + Sbjct: 118 ATGSPRRRLQIAKLYPGVTFTEIRGNVDTRLKKIGELGVADGTVLASAGLNRLGIGNWPG 177 Query: 185 A---ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 AL +PAVGQGA+ ++CR D+ A + T V ERA L G Sbjct: 178 VEFHALGFNDMVPAVGQGAIAVQCRAADAAR---FAPVFDAATKRAVDVERAFQAALGVG 234 Query: 242 CQVPIGSY 249 CQ G++ Sbjct: 235 CQTAFGAH 242 >UniRef50_Q04X38 Bifunctional porphobilinogen deaminase/uroporphyrinogen synthase n=4 Tax=Leptospira RepID=Q04X38_LEPBL Length = 542 Score = 129 bits (323), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 89/278 (32%), Positives = 127/278 (45%), Gaps = 32/278 (11%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + VL+IA+R+S LA Q + V D L P + +EL GD+ L TPL K+G +G+ Sbjct: 1 MSRVLKIASRKSALAKLQTYLVLDALKKKFPNIQIELHFREASGDLDLQTPLWKMGTRGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F ++L L+E + D+ +HS KD+ +E G +V + +R D RD + P+ Sbjct: 61 FTQDLTKDLVEKKVDLVIHSWKDLDLEGHSGTTIVGVLDRADQRDVLLWKKSSLSKNFPS 120 Query: 122 GSIVGTSSLRRQCQLAE----------RRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAV 171 + TSS RR+ L + + LI +RGN+ TR+ K N + D ++LA Sbjct: 121 ELKIQTSSPRREYNLKKFLNNSLPSRYKNSSLIFLPVRGNIQTRIRKWRNSDSDGLVLAK 180 Query: 172 AGLKRL----------------------GLESRIRAALPPEISLPAVGQGAVGIECRLDD 209 A L RL LE I LP +S A QGA+ E R DD Sbjct: 181 AALDRLLSEDFLNSNELEYQEIRKFLKEILEESIFQVLPLSLSPSAPAQGAIAAEVRTDD 240 Query: 210 SRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIG 247 + AL+ E V ER R GGC IG Sbjct: 241 EWALGFVRALSKPEVVSAVEEERNTLKRFGGGCHQKIG 278 >UniRef50_Q9HMY5 Probable porphobilinogen deaminase n=2 Tax=Halobacterium salinarum RepID=HEM3_HALSA Length = 396 Score = 127 bits (318), Expect = 6e-28, Method: Compositional matrix adjust. Identities = 72/159 (45%), Positives = 96/159 (60%), Gaps = 2/159 (1%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M +R+ATR S LAL QA V D L VELV + T GD + D ++ +G G Sbjct: 1 MSSQQIRLATRGSDLALRQAGEVVDTLEDRRHD--VELVEVETEGDRVTDALISDLGKTG 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 FV+ L+ ++E D AVHSMKDVP E P+ L + + RE+P D V+ + L+ LP Sbjct: 59 AFVRALDQEVMEGTVDAAVHSMKDVPTEVPEDLVVAAVPHRENPADVLVTPDGTDLEDLP 118 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL 159 AGS+VGT+SLRR Q+ RP L + +RGNVGTR+ KL Sbjct: 119 AGSVVGTASLRRGAQVQAHRPGLDVEPIRGNVGTRVEKL 157 Score = 68.6 bits (166), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 56/148 (37%), Positives = 79/148 (53%), Gaps = 9/148 (6%) Query: 161 NGEYDAIILAVAGLKRLGLESRIR-AALPPEISLPAVGQGAVGIECRLDDSRTRELLAAL 219 + EYDA+++A GL+R GL + L +PA GQGA+ + R D L AL Sbjct: 246 DTEYDALVMARVGLERTGLLHHVGIEELSTGTHVPATGQGALCVTARRDSDVVDTLRDAL 305 Query: 220 NHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRAL-VGAPDGSQIIRGERRG 278 H T + VTAER + L GGC PIG +A L+ G+ A+ V + DGS+ + GE R Sbjct: 306 EHVRTRVEVTAERVVLEELGGGCIAPIGVHA-LVQGDTIRTAVQVFSQDGSEQV-GETR- 362 Query: 279 APQDAEQMGIS---LAEELLNNGAREIL 303 DAEQ LA +L + GA +++ Sbjct: 363 -ELDAEQYATDARELAADLRDRGAADLI 389 >UniRef50_A8I2X7 Porphobilinogen deaminase n=1 Tax=Chlamydomonas reinhardtii RepID=A8I2X7_CHLRE Length = 380 Score = 118 bits (295), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 91/231 (39%), Positives = 120/231 (51%), Gaps = 13/231 (5%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPG----LVVELVPMVTRGDVILDTPLAKVGGKGL 61 L IATR S LA Q V+ L+A+ L + + + +RGD L +G G Sbjct: 63 LVIATRPSKLAKEQTRQVQQLLLAAAQLKDEQLQLSTLELASRGDTTQGVSLRSLG-SGA 121 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F +EL+ A+L AD++VHS+KD P GL L R DPRD ++ SL L Sbjct: 122 FTEELDQAVLSGAADMSVHSLKDCPAALAPGLLLAACLPRADPRDVLIAPEATSLGELVP 181 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 GS VGTSS RR Q+ P L + LRGNV +RL ++ + + A +LA AGLKRLG+ + Sbjct: 182 GSRVGTSSSRRAAQIKHSFPHLQVVQLRGNVDSRLGRIRSRDIGATVLAAAGLKRLGVMN 241 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232 GAVG+ CR DD LL A++H TAL V AER Sbjct: 242 SDEGD--------TTATGAVGVVCRADDEWVVGLLDAISHRGTALEVAAER 284 >UniRef50_Q18ES3 Hydroxymethylbilane synthase (Porphobilinogen deaminase) n=9 Tax=Halobacteriaceae RepID=Q18ES3_HALWD Length = 394 Score = 114 bits (286), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 66/157 (42%), Positives = 95/157 (60%), Gaps = 4/157 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 L +ATR S LAL QA V++ L V+L+ + TRGD I D + ++G G FV+ Sbjct: 10 TLTLATRGSDLALKQATSVQEALTDER--YEVDLIEVETRGDQIQDELIHQLGKTGAFVR 67 Query: 65 ELEVALLE--NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 L+ +L+ AD AVHSMKD+P + P L + I +R P D ++ + L LP+G Sbjct: 68 ALDKKVLDPTAEADAAVHSMKDMPTDSPDDLVVAGIPQRAPPGDLLITTDGQRLSDLPSG 127 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL 159 + +GTSSLRRQ QL ++R D+ + LRGN+ TR+ KL Sbjct: 128 ATIGTSSLRRQAQLLDQRTDITVEPLRGNIDTRIEKL 164 Score = 74.3 bits (181), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 51/143 (35%), Positives = 74/143 (51%), Gaps = 1/143 (0%) Query: 163 EYDAIILAVAGLKRLGLESRIR-AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNH 221 EYDAI+LA AGL+R GL I L +PA GQGA+ I + + + T ++ A++H Sbjct: 235 EYDAIVLAEAGLQRSGLIHHIEYVQLDTTTFVPAPGQGAIAITTQGEANATAQIREAIDH 294 Query: 222 HETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ 281 T + T ER + L GGC PIG +A L + + A V A DG++ + G R Sbjct: 295 PRTRVETTVERTVLAELGGGCIAPIGVHATLQGEYVHVAAQVFASDGTETVDGSRNLPVD 354 Query: 282 DAEQMGISLAEELLNNGAREILA 304 A +L + GA E++A Sbjct: 355 AHADAAAQFANKLADRGADELIA 377 >UniRef50_Q9PK95 Probable porphobilinogen deaminase n=13 Tax=Chlamydiaceae RepID=HEM3_CHLMU Length = 242 Score = 114 bits (285), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 69/196 (35%), Positives = 106/196 (54%), Gaps = 3/196 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LR+A+R+SPLA+ QAH +L P L +++ T+GD+ TPL V G F + Sbjct: 21 LRLASRKSPLAVLQAHECLRRLQTFFPRLWGQVITETTQGDLDQHTPLHSVENTGFFTDD 80 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 ++ + + D+A+HS KD+P E P+ ++ I DPRD V L P+ + Sbjct: 81 IDFLVQSGKCDLAIHSAKDLP-EKPKA-RVIAITASIDPRDILVFQEKYLLQPFPSRLRI 138 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 G SS RR+ ++ P +I +RG + TRL+ LD ++DAI++A A + RLGL Sbjct: 139 GCSSDRRRALISSLYPSAVITDIRGTIQTRLALLDQQKFDAIVMANAAVSRLGLRLPCTV 198 Query: 186 ALPPEISLPAVGQGAV 201 LPP P G+ A+ Sbjct: 199 VLPPPYH-PFQGRLAI 213 >UniRef50_B0SF66 Bifunctional porphobilinogen deaminase/uroporphyrinogen synthase n=2 Tax=Leptospira biflexa serovar Patoc RepID=B0SF66_LEPBA Length = 511 Score = 112 bits (279), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 82/278 (29%), Positives = 127/278 (45%), Gaps = 33/278 (11%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + ++I R S L+ Q H V + L + L E + + GD L TPL + GG+G+ Sbjct: 1 MSETIKIGGRSSLLSRIQIHTVTNALKEKNKDLNFETIFRESSGDKDLTTPLWQFGGQGI 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F K+L+ LL ++ DI +HS KD+ ++ + L+ + RED RD + ++ LP Sbjct: 61 FTKDLQEDLLNHKVDIVIHSYKDMDLKERKETTLIPVLPREDVRDVLLFKKNKWIN-LPN 119 Query: 122 GSIVGTSSLRRQCQLAE----------RRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAV 171 + TSS RR+ + E ++ I S+RGN+ TRL K + E I++A Sbjct: 120 EITILTSSPRREYHIKEFLRNYFPTPINNFEIKIESVRGNIQTRLRKYLDHESGGILVAK 179 Query: 172 AGLKRL----------------------GLESRIRAALPPEISLPAVGQGAVGIECRLDD 209 A L R+ + + LP I A QGA+ E R +D Sbjct: 180 AALDRILNFQDPDQLLPELKEIQQLIKDTMNVSLFMVLPSSIFPSAPAQGALCAEIRKED 239 Query: 210 SRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIG 247 LL+ ++ ET L ER + +R GGC IG Sbjct: 240 KHLETLLSKISDSETNLTTNEEREILSRYGGGCHQKIG 277 >UniRef50_Q6MEK3 Putative Porphobilinogen deaminase n=2 Tax=Parachlamydiaceae RepID=Q6MEK3_PARUW Length = 233 Score = 111 bits (277), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 69/215 (32%), Positives = 108/215 (50%), Gaps = 3/215 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 + + R SPL+ Q + L + +P + + T GD+ T L + F KE Sbjct: 18 ISVGARSSPLSRAQVQEILKALRSFYPSIEFTISYFDTIGDLDQKTSLRDLDKTNFFTKE 77 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 ++ A+L+ + I +HS KD+P P GL L+ + + D D V + ++L LP S + Sbjct: 78 IDEAILQKKCQIGIHSAKDLPDPIPDGLQLICLTKGVDCSDVLVLRDGETLQTLPPHSRI 137 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 TSS+RR+ + R D I LRG + RL+ L+ + D +++A A L RLGL R Sbjct: 138 ATSSIRRENIVKLLRNDFIFLDLRGTIHQRLALLEKKQADGVVVAEAALIRLGLTHLNRI 197 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALN 220 LP GQG + I R DD++ + L A L+ Sbjct: 198 RLP---GTTVEGQGQLAIIARKDDAKMQTLFACLD 229 >UniRef50_UPI0001B4213A porphobilinogen deaminase n=1 Tax=Listeria monocytogenes LO28 RepID=UPI0001B4213A Length = 128 Score = 106 bits (264), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 52/122 (42%), Positives = 79/122 (64%), Gaps = 2/122 (1%) Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246 +PPE+ LPAVGQGA+ IECR D + R++L +++H ET + V AER +L GGC++PI Sbjct: 8 IPPEVCLPAVGQGALAIECRESDQQIRDMLTSIHHEETGICVEAERVFLKKLNGGCEIPI 67 Query: 247 GSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEV 306 +A + + + LVG DGS I+ E+ GA + ++G +AE+LL+ GA I+ E+ Sbjct: 68 AGFATRANEFVQFKGLVGNADGSIILESEQVGA--NPSEIGNKVAEDLLSEGADTIIKEL 125 Query: 307 YN 308 N Sbjct: 126 RN 127 >UniRef50_UPI000155526F PREDICTED: similar to hydroxymethylbilane synthase n=1 Tax=Ornithorhynchus anatinus RepID=UPI000155526F Length = 218 Score = 104 bits (260), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 56/112 (50%), Positives = 73/112 (65%), Gaps = 4/112 (3%) Query: 76 DIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLDALPAGSIVGTSSLRR 132 D+ VHS+KD+P P G + +C+RE P DA V + +L LP S+VGTSSLRR Sbjct: 91 DLVVHSLKDLPTVLPPGFTIGAVCKRESPYDAVVFHPKHVGKTLATLPEKSVVGTSSLRR 150 Query: 133 QCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESRI 183 QL + P L +S+RGN+ TRL KLD E+ AIILA AGL+RLG +SR+ Sbjct: 151 AAQLQRKFPHLEFKSIRGNLNTRLRKLDELQEFSAIILAAAGLQRLGWQSRL 202 >UniRef50_UPI0001698669 porphobilinogen deaminase n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2' RepID=UPI0001698669 Length = 136 Score = 101 bits (252), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 65/137 (47%), Positives = 81/137 (59%), Gaps = 19/137 (13%) Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231 AGLKRLG E RI A + PE SLPA+GQGA+GIECR DD++ L+A L+H +TA V AE Sbjct: 8 AGLKRLGFEQRITAFIAPEQSLPAIGQGAIGIECRSDDAQVNALIAPLHHVDTAACVHAE 67 Query: 232 RAMNTRLEGG-----CQ-----VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ 281 RAMN RL GG C+ VP S + W R+ V ++ GE G P Sbjct: 68 RAMNNRLMGGSPCADCRLRDAGVPATSGCVV----WWARSTV-----ARSCVGEAEGTPD 118 Query: 282 DAEQMGISLAEELLNNG 298 +AE +G+ LAE LL G Sbjct: 119 EAESLGVGLAERLLELG 135 >UniRef50_C0EAN0 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum DSM 5476 RepID=C0EAN0_9CLOT Length = 292 Score = 99.8 bits (247), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 92/291 (31%), Positives = 133/291 (45%), Gaps = 18/291 (6%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 + I Q+ L+ A ++ L + HP L ELVP+ G T L + Sbjct: 15 IHIGCAQNELSRNFADHLAQCLHSYHPELTAELVPIKNTGADEEPT---------LVARR 65 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI- 124 LE AL++ R D+AV+ D+P+E L +V I RED RDA V + P S Sbjct: 66 LEQALIDCRVDLAVYHALDLPLELHPELPIVAISSREDVRDALV---FPQGKQQPDFSKP 122 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +G +S R+Q QL PD I + G V +L++LD GEY A++L A L GL+ R+ Sbjct: 123 IGCTSRRQQVQLHRVFPDCITAPVGGTVAEQLARLDQGEYGALVLPAAQLGWFGLQQRVG 182 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 E +PA G A+ ++ R + LL + ++ V ER LE Sbjct: 183 QLFCVEELVPAAGHAAIAVQAR--EEFDAGLLECFHSWDSWDAVFCEREFARALEEE-PG 239 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIR-GERRGAPQDAEQMGISLAEEL 294 PI +AE + GE A + I R G +DA ++G LA EL Sbjct: 240 PIAVHAE-VKGETLSVVGFYADEAEGIYRMSSMSGDRKDAGRLGFELAAEL 289 >UniRef50_Q6MHU0 Hydroxymethylbilane synthase n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MHU0_BDEBA Length = 502 Score = 96.3 bits (238), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 80/270 (29%), Positives = 126/270 (46%), Gaps = 29/270 (10%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LRI+ R+S LA QA+ V D L +P + ++ + GD L PL K+ KG+F ++ Sbjct: 3 LRISARKSDLARLQAYMVGDALKEKNPQIEIDYRFRESLGDKNLTDPLWKIPEKGVFTED 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV--SNNYDSLDALPAGS 123 LL + D+ VHS KD+P E + R D RD + +++D + Sbjct: 63 FFGELLRDETDLVVHSWKDLPTEHKSETVIAATLPRADQRDLLLVKKSHFDKIKTSKTLK 122 Query: 124 IVGTSSLRRQCQLA----ERRP----DLIIRSLRGNVGTRLSKL-DNGEYDAIILAVAGL 174 + +SS RR+ L E P D+ S+RGN+ TR+ KL ++ E D +I+A A Sbjct: 123 VF-SSSPRREYNLTGFFKEHLPFGLQDVKFESVRGNMLTRVRKLIESPETDGLIVAKAAF 181 Query: 175 KRL-------GLESRIR----------AALPPEISLPAVGQGAVGIECRLDDSRTRELLA 217 RL LE + + LP ++ A QGA+ +E ++LL Sbjct: 182 DRLFSATLPEFLEGQQQLRQYFNELNWVVLPLSVNPNAAAQGALAVEVLKSRQDLQDLLQ 241 Query: 218 ALNHHETALRVTAERAMNTRLEGGCQVPIG 247 +++H +T ER + + GGC IG Sbjct: 242 SIHHADTFHCSQKERDVLSSFGGGCHQKIG 271 >UniRef50_Q6Q923 Predicted porphobilinogen deaminase n=2 Tax=environmental samples RepID=Q6Q923_9GAMM Length = 291 Score = 94.7 bits (234), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 83/247 (33%), Positives = 116/247 (46%), Gaps = 15/247 (6%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 ++IA+R S LAL Q K S +++ + T GD I + K FV Sbjct: 2 TIKIASRSSKLALAQVEEFVKKFGISD----YKIIKVKTEGD-IKSANGETLFDKAHFVS 56 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 +++ LL ADIAVHS KD P GL L + +D + + D + Sbjct: 57 DVQKCLLNGEADIAVHSAKDTPAGETTGL-LRYFLPSQSNQDVLI---FREEDKFNSEMK 112 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSSLRRQ Q + I +L GNV TRL KL GEYD IILA AGL RL L + ++ Sbjct: 113 LGTSSLRRQLQAKHHLNAINIVNLSGNVDTRLEKLSQGEYDCIILAKAGLARLKLLNELQ 172 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSR--TRELLAALNHHETAL--RVTAERAMNTRLEG 240 + + A GQG + IE D S LL ++ + L ++ ER++ + Sbjct: 173 YEVMDWST--ASGQGFLCIEVLNDPSADIYNFLLKSIREIDLNLGKNISTERSILEAINA 230 Query: 241 GCQVPIG 247 GC I Sbjct: 231 GCNSAIS 237 >UniRef50_C0DZX9 Putative uncharacterized protein n=1 Tax=Corynebacterium matruchotii ATCC 33806 RepID=C0DZX9_9CORY Length = 152 Score = 93.6 bits (231), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 54/150 (36%), Positives = 80/150 (53%), Gaps = 1/150 (0%) Query: 156 LSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTREL 215 ++K+ +GE DA++LA AGL R+ P LPA QGA+ +ECR DD+ T Sbjct: 1 MAKVHDGELDAVVLAYAGLSRVHRADEATEVFDPLEFLPAPAQGALAVECRADDADTIAA 60 Query: 216 LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRG 274 + + + ER + RLE GC P+ +YA + D + L A V A DGS +R Sbjct: 61 ITTIADSKAYACAHTERVVLARLEAGCTAPVAAYATVAADNIMTLHAAVIAMDGSATLRA 120 Query: 275 ERRGAPQDAEQMGISLAEELLNNGAREILA 304 G AE +G+++A LL++GA +LA Sbjct: 121 TAAGPIDTAENLGMTVARALLDDGASSLLA 150 >UniRef50_D0RNS6 Putative porphobilinogen deaminase (Pbg)(Hydroxymethylbilane synthase) (Hmbs) (Pre-uroporphyrinogen synthase) n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RNS6_9RICK Length = 492 Score = 88.6 bits (218), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 79/277 (28%), Positives = 119/277 (42%), Gaps = 28/277 (10%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L I +R S LA Q VK +L + + T+GD K G G+F Sbjct: 5 LIIGSRASFLAKIQTFIVKQELKKKIKNIKITTKYHSTKGDKNQGHMPWKNLGYGIFTTS 64 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L L+ + VHS KD+PV + + R+DPRD + IV Sbjct: 65 LTNELINKNFNCVVHSYKDLPV--LKSKTDYYVITRDDPRDVLLV---KKKCLNKKKFIV 119 Query: 126 GTSSLRRQCQLAERR-----PDLIIRSLRGNVGTRLSK-LDNGEYDAIILAVAGLKR--- 176 GTSS RR+ + + + D+ +++RGNV TRL K + +YDA+ +A A + R Sbjct: 120 GTSSPRRKSSVKDLKDLTGIKDIKTKTIRGNVTTRLLKVISKNQYDAVFMAKAAIDRIFK 179 Query: 177 -------------LGLESRIR-AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHH 222 L L + + LP I A QGA+ +E +D +T+ L +N Sbjct: 180 YGNKVDKVETKKFLNLFKKFKPFILPLSIFPTAASQGAIAVEYLKNDKKTKSTLNKINCK 239 Query: 223 ETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWL 259 +T ER++ + GGC + IG E I +L Sbjct: 240 KTLSICNQERSLLKKYGGGCGLDIGITIEEIKNNNFL 276 >UniRef50_A8CBG6 Porphobilinogen deaminase n=3 Tax=Toxoplasma gondii RepID=A8CBG6_TOXGO Length = 747 Score = 88.6 bits (218), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 41/74 (55%), Positives = 52/74 (70%) Query: 36 VELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGL 95 + +VPM T GD L PLA+VGGKGLF KEL++ALL + D+ VHS+KDVP E P+G + Sbjct: 269 LRIVPMQTTGDKELHLPLAQVGGKGLFTKELDLALLHGQVDVVVHSLKDVPTELPEGTEI 328 Query: 96 VTICEREDPRDAFV 109 REDPRDA + Sbjct: 329 GAYLPREDPRDALI 342 Score = 79.0 bits (193), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 56/160 (35%), Positives = 75/160 (46%), Gaps = 33/160 (20%) Query: 125 VGTSSLRRQCQLAERRP--DLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 +GT SLRRQ L P + LRGNV TR+S+++ G DA +LA AGLKRL L S Sbjct: 445 IGTCSLRRQALLYALLPPSSFQLMGLRGNVQTRMSRIEKGTLDATLLAAAGLKRLNLLSA 504 Query: 183 IRAA-------------------------------LPPEISLPAVGQGAVGIECRLDDSR 211 + A LP ++ +PAV QG +G++CR D+ Sbjct: 505 MLAPSPSATPSPCPAPSPNETSRGTEPGGCVEAVLLPADVFVPAVCQGIIGVQCRSADTG 564 Query: 212 TRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAE 251 LL LN + + ERA L+G C+ PI AE Sbjct: 565 ILSLLRELNSPSSRGQALCERAFLRALDGSCRTPIAGIAE 604 >UniRef50_C5LJF7 Porphobilinogen deaminase, putative n=5 Tax=Perkinsus marinus ATCC 50983 RepID=C5LJF7_9ALVE Length = 556 Score = 79.3 bits (194), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 81/282 (28%), Positives = 122/282 (43%), Gaps = 40/282 (14%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +VL I +R+S LA Q + D L+ G+ VE GD L PL K+ G+F Sbjct: 8 SVLHIGSRRSDLARLQTLMIAD-LLQDEMGVKVECHYREAPGDTNLKDPLWKMPETGVFT 66 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 L L+ D+ VHS KD+P+ G +V R DPRD + D+++ + + Sbjct: 67 SFLRDGLMNGAFDLVVHSWKDLPLAEESGTTVVATLPRADPRDLLLIRR-DAIEEMTSEG 125 Query: 124 ---IVGTSSLRRQCQLAERRPDLI-------IRSLRGNVGTRLSKL-DNGEYD------- 165 IV +SS RRQ L ++ R +RGN+ TR+ KL D +D Sbjct: 126 GKLIVLSSSPRRQFNLTPFLESVVPGVTSVQFRDVRGNIQTRMKKLMDPTIHDESLGCRP 185 Query: 166 -AIILAVAGLKRL----------------GLESRIRAALPPEISLP-AVGQGAVGIECRL 207 +++A A + R G S R + P + P A QGA+GIE Sbjct: 186 HGLVVAKAAVDRFIRSTREEFKESRQLVQGYISECRCMVLPLSANPTAAAQGALGIEVST 245 Query: 208 --DDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIG 247 + R+++ +LN T + E+ + GGC IG Sbjct: 246 APEKEHVRKIVRSLNDRSTFDAASKEKELLNSYGGGCHQKIG 287 >UniRef50_Q401C3 Hydroxymethylbilane synthase (Fragment) n=7 Tax=Coelomata RepID=Q401C3_CAPHI Length = 109 Score = 79.3 bits (194), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 41/78 (52%), Positives = 54/78 (69%), Gaps = 1/78 (1%) Query: 114 DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVA 172 +L+ LP S+VGTSSLRR QL + P L R++RGN+ TRL KLD E+ AIILA A Sbjct: 30 KTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRNIRGNLNTRLRKLDELQEFSAIILAAA 89 Query: 173 GLKRLGLESRIRAALPPE 190 GL+R+G ++R+ L PE Sbjct: 90 GLQRMGWQNRVGQILHPE 107 >UniRef50_B0KCR7 Porphobilinogen deaminase n=3 Tax=Thermoanaerobacter RepID=B0KCR7_THEP3 Length = 168 Score = 75.9 bits (185), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 49/158 (31%), Positives = 81/158 (51%), Gaps = 7/158 (4%) Query: 142 DLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAV 201 D+ I +RGNV TRL K++ D I+L+ AGL RLGLES I PP++ +PA QG + Sbjct: 10 DIQIVPIRGNVRTRLKKMEELNLDGIVLSAAGLHRLGLESIITEYFPPDVVVPAPCQGIL 69 Query: 202 GIE-CRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYA----ELIDGE 256 +E D+ +E + + T + ER + C+ P G+YA E + + Sbjct: 70 AVEIAESFDNIFQEFYSYIVDRRTFFEASVERELLKAFGVNCRQPFGAYAQYRKEKDEEK 129 Query: 257 IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 I ++ + D ++++ E G ++ ++M L EE Sbjct: 130 INIKVVYQKED--KLLKSEVTGLIEETDKMIEKLIEEF 165 >UniRef50_UPI0001742E92 Porphobilinogen deaminase n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI0001742E92 Length = 119 Score = 62.8 bits (151), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 33/108 (30%), Positives = 60/108 (55%), Gaps = 2/108 (1%) Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246 + +PA GQG + I+CR +D++ R LL +N E + AER + +GGC PI Sbjct: 5 FDTDFFMPAPGQGILCIQCRENDNKIRHLLEIINDDEVTMMCEAEREFSKIFDGGCHTPI 64 Query: 247 GSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 G + +I+G+ + +GS++++ E G ++ +++ LAEE+ Sbjct: 65 GC-SSVIEGDTLKLKGMFNDNGSRMLK-EVEGNKENPKEIAQKLAEEI 110 >UniRef50_Q1HRH6 Hydroxymethylbilane synthase-like protein n=1 Tax=Aedes aegypti RepID=Q1HRH6_AEDAE Length = 349 Score = 58.9 bits (141), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 35/110 (31%), Positives = 50/110 (45%), Gaps = 15/110 (13%) Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236 +G E RI + P L AVGQGA+ +ECR +D +L+ L H ET ++ ER+ Sbjct: 1 MGWEKRIDQVIEPSEILYAVGQGALAVECRSNDEYILNMLSKLCHLETQCKILVERSFLK 60 Query: 237 RLEGGCQVPIGSYAEL------------IDGEIWL---RALVGAPDGSQI 271 L GGC P+ L I G +W + + A DG + Sbjct: 61 TLGGGCSAPVAVCTSLKRKHDSKSNYLNIQGAVWSLDGKTEIRADDGCSV 110 >UniRef50_B8N6H4 Putative uncharacterized protein n=1 Tax=Aspergillus flavus NRRL3357 RepID=B8N6H4_ASPFN Length = 90 Score = 48.1 bits (113), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 30/78 (38%), Positives = 40/78 (51%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LRI TR+S LA+ QA +++ L PG E+ + T GD T L G K L+ E Sbjct: 11 LRIGTRRSNLAMVQAEGIRNCLQKIAPGRSFEIEALRTLGDRDQLTALYNFGAKSLWTTE 70 Query: 66 LEVALLENRADIAVHSMK 83 LE L D+ VH +K Sbjct: 71 LEEKLNAGELDVIVHCLK 88 >UniRef50_UPI0000D9FBB5 PREDICTED: similar to lethal (3) 02640 CG9165-PA n=1 Tax=Macaca mulatta RepID=UPI0000D9FBB5 Length = 105 Score = 42.7 bits (99), Expect = 0.016, Method: Compositional matrix adjust. Identities = 34/105 (32%), Positives = 44/105 (41%), Gaps = 17/105 (16%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI +R+S LA Q V D+L G V LV M G+F Sbjct: 8 TLRIGSRRSDLARLQTLMVADRL--EEMGYKVVLVGM---------------PETGVFTT 50 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV 109 L LL+ D+ VHS KD+P+ G + R DPRD + Sbjct: 51 FLRQKLLDGSVDLVVHSWKDLPLAEEAGTTVAATLPRADPRDLII 95 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_B7LU53 Porphobilinogen deaminase n=87 Tax=cellular orga... 469 e-131 UniRef50_B5FN93 Porphobilinogen deaminase n=168 Tax=cellular org... 461 e-128 UniRef50_C0QU69 Porphobilinogen deaminase n=4 Tax=Bacteria RepID... 439 e-122 UniRef50_Q3ACT3 Porphobilinogen deaminase n=2 Tax=Bacteria RepID... 434 e-120 UniRef50_B5YJZ4 Porphobilinogen deaminase n=2 Tax=Bacteria RepID... 432 e-120 UniRef50_Q0I178 Porphobilinogen deaminase n=45 Tax=Bacteria RepI... 425 e-118 UniRef50_D1BNZ5 Porphobilinogen deaminase n=3 Tax=Veillonella Re... 422 e-117 UniRef50_Q8YVU6 Porphobilinogen deaminase n=50 Tax=cellular orga... 421 e-116 UniRef50_C0Q9U2 HemC n=2 Tax=Bacteria RepID=C0Q9U2_DESAH 419 e-116 UniRef50_A1AUE7 Porphobilinogen deaminase n=44 Tax=Bacteria RepI... 412 e-114 UniRef50_Q8DIE4 Porphobilinogen deaminase n=11 Tax=cellular orga... 411 e-113 UniRef50_B5EBG8 Porphobilinogen deaminase n=166 Tax=Bacteria Rep... 409 e-113 UniRef50_C9KL85 Hydroxymethylbilane synthase n=1 Tax=Mitsuokella... 409 e-113 UniRef50_A6TJD5 Porphobilinogen deaminase n=2 Tax=Firmicutes Rep... 409 e-112 UniRef50_Q65GK1 Porphobilinogen deaminase n=98 Tax=Bacillales Re... 408 e-112 UniRef50_Q31PM2 Porphobilinogen deaminase n=8 Tax=cellular organ... 400 e-110 UniRef50_Q5ZRY6 Porphobilinogen deaminase n=6 Tax=Legionella Rep... 397 e-109 UniRef50_C6HUG2 Porphobilinogen deaminase n=1 Tax=Leptospirillum... 397 e-109 UniRef50_B2A1G7 Porphobilinogen deaminase n=1 Tax=Natranaerobius... 397 e-109 UniRef50_Q2RJ26 Porphobilinogen deaminase n=5 Tax=Clostridia Rep... 396 e-109 UniRef50_Q30Y29 Porphobilinogen deaminase n=13 Tax=Bacteria RepI... 391 e-107 UniRef50_B3QWI1 Porphobilinogen deaminase n=12 Tax=Chlorobiaceae... 390 e-107 UniRef50_C9R7U0 Porphobilinogen deaminase n=1 Tax=Ammonifex dege... 390 e-107 UniRef50_P08397 Porphobilinogen deaminase n=59 Tax=Chordata RepI... 389 e-107 UniRef50_B3E2H7 Porphobilinogen deaminase n=3 Tax=Proteobacteria... 388 e-106 UniRef50_Q54P93 Porphobilinogen deaminase n=1 Tax=Dictyostelium ... 386 e-106 UniRef50_Q2LQU2 Porphobilinogen deaminase n=1 Tax=Syntrophus aci... 384 e-105 UniRef50_Q4L709 Porphobilinogen deaminase n=88 Tax=Bacillales Re... 384 e-105 UniRef50_A8PKX6 Porphobilinogen deaminase n=2 Tax=Gammaproteobac... 382 e-104 UniRef50_A7NKU8 Porphobilinogen deaminase n=5 Tax=Bacteria RepID... 380 e-104 UniRef50_A3ETN3 Porphobilinogen deaminase n=2 Tax=Leptospirillum... 380 e-104 UniRef50_Q1J288 Porphobilinogen deaminase n=5 Tax=Deinococci Rep... 380 e-104 UniRef50_A7GYU4 Porphobilinogen deaminase n=34 Tax=Campylobacter... 379 e-104 UniRef50_A6WXJ2 Porphobilinogen deaminase n=56 Tax=cellular orga... 378 e-103 UniRef50_B2S842 Porphobilinogen deaminase n=38 Tax=Rhizobiales R... 375 e-103 UniRef50_Q180R9 Porphobilinogen deaminase n=11 Tax=Bacteria RepI... 375 e-102 UniRef50_A6Q7Y4 Porphobilinogen deaminase n=7 Tax=Epsilonproteob... 375 e-102 UniRef50_B6FXV9 Putative uncharacterized protein n=1 Tax=Clostri... 373 e-102 UniRef50_D2R3S6 Porphobilinogen deaminase n=2 Tax=Planctomycetac... 373 e-102 UniRef50_Q43316 Porphobilinogen deaminase, chloroplastic n=61 Ta... 372 e-101 UniRef50_D0LUE1 Porphobilinogen deaminase n=1 Tax=Haliangium och... 371 e-101 UniRef50_A5VM67 Porphobilinogen deaminase n=9 Tax=Lactobacillus ... 371 e-101 UniRef50_O94048 Porphobilinogen deaminase n=53 Tax=Saccharomycet... 368 e-100 UniRef50_Q3YSA8 Porphobilinogen deaminase n=17 Tax=Rickettsiales... 368 e-100 UniRef50_C8WXM9 Porphobilinogen deaminase n=2 Tax=Alicyclobacill... 367 e-100 UniRef50_A8LIJ6 Porphobilinogen deaminase n=11 Tax=Alphaproteoba... 365 1e-99 UniRef50_P28789 Porphobilinogen deaminase n=18 Tax=Saccharomycet... 364 2e-99 UniRef50_A9A1A1 Probable porphobilinogen deaminase n=3 Tax=Thaum... 364 2e-99 UniRef50_C1CYD9 Porphobilinogen deaminase n=3 Tax=Deinococci Rep... 364 2e-99 UniRef50_D1CBT4 Porphobilinogen deaminase n=1 Tax=Thermobaculum ... 363 4e-99 UniRef50_Q8RFP5 Porphobilinogen deaminase n=16 Tax=Fusobacteriac... 362 1e-98 UniRef50_C3XEZ5 Porphobilinogen deaminase n=3 Tax=Campylobactera... 361 1e-98 UniRef50_Q5HBG1 Porphobilinogen deaminase n=2 Tax=Ehrlichia rumi... 361 2e-98 UniRef50_UPI00017922DC PREDICTED: similar to porphobilinogen dea... 360 3e-98 UniRef50_B0K2L4 Porphobilinogen deaminase n=7 Tax=Bacteria RepID... 360 3e-98 UniRef50_Q4HT06 Porphobilinogen deaminase n=1 Tax=Campylobacter ... 359 8e-98 UniRef50_B3T8H9 Putative Porphobilinogen deaminase, dipyromethan... 357 2e-97 UniRef50_C3WGN0 Porphobilinogen deaminase n=5 Tax=Fusobacterium ... 357 4e-97 UniRef50_C6XGK7 Porphobilinogen deaminase n=1 Tax=Candidatus Lib... 356 5e-97 UniRef50_UPI0001926E0E PREDICTED: similar to hydroxymethylbilane... 355 9e-97 UniRef50_UPI0000583C22 PREDICTED: hypothetical protein n=1 Tax=S... 355 1e-96 UniRef50_Q2S2A6 Porphobilinogen deaminase n=1 Tax=Salinibacter r... 354 2e-96 UniRef50_A6GVP0 Hydroxymethylbilane synthase n=18 Tax=Bacteroide... 353 6e-96 UniRef50_C6WZF5 Porphobilinogen deaminase n=1 Tax=Flavobacteriac... 352 7e-96 UniRef50_A8U3E9 Porphobilinogen deaminase n=1 Tax=alpha proteoba... 352 1e-95 UniRef50_C7N5L0 Porphobilinogen deaminase n=2 Tax=Slackia RepID=... 351 2e-95 UniRef50_Q11XT5 Porphobilinogen deaminase n=8 Tax=Bacteria RepID... 350 3e-95 UniRef50_A6DBT5 Porphobilinogen deaminase n=1 Tax=Caminibacter m... 350 3e-95 UniRef50_A9FDP9 Porphobilinogen deaminase n=1 Tax=Sorangium cell... 350 4e-95 UniRef50_A6GB01 Porphobilinogen deaminase n=2 Tax=Bacteria RepID... 349 8e-95 UniRef50_C4Z552 Porphobilinogen deaminase n=8 Tax=Bacteria RepID... 349 1e-94 UniRef50_C0YV01 Hydroxymethylbilane synthase n=1 Tax=Chryseobact... 347 3e-94 UniRef50_A3CL78 Porphobilinogen deaminase n=1 Tax=Streptococcus ... 346 5e-94 UniRef50_C3PNS9 Porphobilinogen deaminase n=15 Tax=Rickettsia Re... 345 9e-94 UniRef50_D0NJW2 Porphobilinogen deaminase n=2 Tax=Phytophthora i... 345 1e-93 UniRef50_B3U3W9 Hydroxymethylbilane synthetase n=1 Tax=Oxyrrhis ... 345 1e-93 UniRef50_B2W5W6 Porphobilinogen deaminase n=2 Tax=Pleosporineae ... 343 3e-93 UniRef50_UPI00006CBE06 porphobilinogen deaminase family protein ... 343 4e-93 UniRef50_Q1V167 Hydroxymethylbilane synthase n=3 Tax=Candidatus ... 343 4e-93 UniRef50_A3ZKX4 Porphobilinogen deaminase n=1 Tax=Blastopirellul... 343 5e-93 UniRef50_C4ZFT9 Porphobilinogen deaminase n=1 Tax=Eubacterium re... 342 8e-93 UniRef50_A8MDU3 Probable porphobilinogen deaminase n=2 Tax=Therm... 342 9e-93 UniRef50_A0LRF1 Porphobilinogen deaminase n=1 Tax=Acidothermus c... 341 2e-92 UniRef50_A2Q9P7 Catalytic activity: 4 porphobilinogen+H(2)O<=>hy... 341 2e-92 UniRef50_C1ZK04 Porphobilinogen deaminase n=1 Tax=Planctomyces l... 340 4e-92 UniRef50_B8MVK7 Porphobilinogen deaminase, putative n=1 Tax=Tala... 339 6e-92 UniRef50_A5CDH4 Porphobilinogen deaminase n=2 Tax=Orientia tsuts... 339 6e-92 UniRef50_Q0TQG4 Porphobilinogen deaminase n=32 Tax=Clostridium R... 339 8e-92 UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia... 338 1e-91 UniRef50_B5G8F1 Porphobilinogen deaminase n=1 Tax=Streptomyces s... 338 2e-91 UniRef50_C1AA38 Porphobilinogen deaminase n=1 Tax=Gemmatimonas a... 337 2e-91 UniRef50_Q82P95 Porphobilinogen deaminase 2 n=14 Tax=Actinomycet... 336 5e-91 UniRef50_Q8TXC8 Probable porphobilinogen deaminase n=1 Tax=Metha... 333 5e-90 UniRef50_A4QB59 Porphobilinogen deaminase n=15 Tax=Corynebacteri... 333 5e-90 UniRef50_A2BL26 Probable porphobilinogen deaminase n=2 Tax=Therm... 332 8e-90 UniRef50_D0J8N1 Porphobilinogen deaminase n=2 Tax=Blattabacteriu... 332 1e-89 UniRef50_C1F251 Hydroxymethylbilane synthase n=1 Tax=Acidobacter... 332 1e-89 UniRef50_C8WIZ2 Porphobilinogen deaminase n=2 Tax=Coriobacteriac... 332 1e-89 UniRef50_A8MGE4 Porphobilinogen deaminase n=30 Tax=cellular orga... 332 1e-89 UniRef50_C7NFP7 Hydroxymethylbilane synthase n=7 Tax=Actinomycet... 331 2e-89 UniRef50_B3DZQ6 Porphobilinogen deaminase n=1 Tax=Methylacidiphi... 330 3e-89 UniRef50_Q09899 Porphobilinogen deaminase n=2 Tax=Schizosaccharo... 330 4e-89 UniRef50_Q0BX92 Porphobilinogen deaminase n=1 Tax=Hyphomonas nep... 329 9e-89 UniRef50_A0DD68 Chromosome undetermined scaffold_46, whole genom... 328 1e-88 UniRef50_A4XK06 Porphobilinogen deaminase n=2 Tax=Clostridia Rep... 328 2e-88 UniRef50_C4QMG7 Hydroxymethylbilane synthase (Porphobilinogen de... 327 4e-88 UniRef50_Q8D2W2 HemC protein n=1 Tax=Wigglesworthia glossinidia ... 327 5e-88 UniRef50_Q7UPN0 Porphobilinogen deaminase n=1 Tax=Rhodopirellula... 326 5e-88 UniRef50_A4CHM3 Porphobilinogen deaminase n=4 Tax=Bacteroidetes ... 325 2e-87 UniRef50_Q4T5L1 Chromosome undetermined SCAF9206, whole genome s... 325 2e-87 UniRef50_Q47LA7 Porphobilinogen deaminase n=3 Tax=Actinomycetale... 324 2e-87 UniRef50_C6XKH7 Porphobilinogen deaminase n=1 Tax=Hirschia balti... 324 3e-87 UniRef50_Q9F7M2 Predicted porphobilinogen deaminase n=2 Tax=Bact... 323 4e-87 UniRef50_A3MLK5 Porphobilinogen deaminase n=155 Tax=Proteobacter... 323 4e-87 UniRef50_B2IAW6 Porphobilinogen deaminase n=4 Tax=Alphaproteobac... 323 5e-87 UniRef50_C2GGB5 Porphobilinogen deaminase n=2 Tax=Corynebacteriu... 323 5e-87 UniRef50_B8GXG1 Porphobilinogen deaminase n=8 Tax=Caulobacterace... 323 6e-87 UniRef50_A8SQW4 Putative uncharacterized protein n=1 Tax=Coproco... 323 6e-87 UniRef50_C6XST0 Porphobilinogen deaminase n=2 Tax=Pedobacter Rep... 323 7e-87 UniRef50_O29026 Probable porphobilinogen deaminase n=1 Tax=Archa... 322 1e-86 UniRef50_D1BFI8 Hydroxymethylbilane synthase n=4 Tax=Actinomycet... 322 1e-86 UniRef50_Q46CH0 Probable porphobilinogen deaminase n=7 Tax=Eurya... 322 1e-86 UniRef50_B3RTQ8 Putative uncharacterized protein n=1 Tax=Trichop... 322 2e-86 UniRef50_B0D5Q2 Predicted protein n=1 Tax=Laccaria bicolor S238N... 322 2e-86 UniRef50_B9XN63 Porphobilinogen deaminase n=1 Tax=bacterium Elli... 321 2e-86 UniRef50_A0QLI0 Porphobilinogen deaminase n=69 Tax=Actinomycetal... 321 2e-86 UniRef50_C5RMN3 Porphobilinogen deaminase n=1 Tax=Clostridium ce... 320 4e-86 UniRef50_C1TM53 Porphobilinogen deaminase n=1 Tax=Dethiosulfovib... 320 4e-86 UniRef50_D2NS36 Porphobilinogen deaminase n=2 Tax=Micrococcaceae... 320 5e-86 UniRef50_B6W7F3 Putative uncharacterized protein n=1 Tax=Anaeroc... 319 6e-86 UniRef50_D1VCA1 Porphobilinogen deaminase n=1 Tax=Frankia sp. Eu... 317 3e-85 UniRef50_UPI000174444E Hydroxymethylbilane synthase n=1 Tax=Verr... 317 3e-85 UniRef50_C6R3Y0 Hydroxymethylbilane synthase n=1 Tax=Rothia muci... 317 4e-85 UniRef50_B6JII8 Porphobilinogen deaminase n=11 Tax=Bradyrhizobia... 317 4e-85 UniRef50_C2FZW8 Porphobilinogen deaminase n=2 Tax=Sphingobacteri... 316 6e-85 UniRef50_A8AAB4 Probable porphobilinogen deaminase n=1 Tax=Ignic... 316 6e-85 UniRef50_C9M5W1 Hydroxymethylbilane synthase n=1 Tax=Jonquetella... 316 7e-85 UniRef50_Q1EPC8 Porphobilinogen deaminase, chloroplast (Hydroxym... 316 8e-85 UniRef50_Q57989 Probable porphobilinogen deaminase n=11 Tax=Meth... 315 1e-84 UniRef50_D2RH82 Porphobilinogen deaminase n=2 Tax=Archaeoglobace... 315 2e-84 UniRef50_Q2NEP4 HemC n=4 Tax=Methanobacteriaceae RepID=Q2NEP4_METST 314 3e-84 UniRef50_A4WN24 Probable porphobilinogen deaminase n=3 Tax=Therm... 313 4e-84 UniRef50_C0BZ93 Putative uncharacterized protein n=1 Tax=Clostri... 312 1e-83 UniRef50_A1DGB8 Porphobilinogen deaminase n=1 Tax=Neosartorya fi... 312 1e-83 UniRef50_C5CB88 Porphobilinogen deaminase n=5 Tax=Actinomycetale... 311 2e-83 UniRef50_D1C4S0 Porphobilinogen deaminase n=1 Tax=Sphaerobacter ... 308 2e-82 UniRef50_O26960 Probable porphobilinogen deaminase n=1 Tax=Metha... 307 2e-82 UniRef50_UPI0001BC2D4C glutamyl-tRNA reductase n=1 Tax=Brevibact... 307 3e-82 UniRef50_Q6AHF1 Porphobilinogen deaminase n=5 Tax=Actinobacteria... 304 2e-81 UniRef50_C6V4N6 Porphobilinogen deaminase n=2 Tax=Neorickettsia ... 304 2e-81 UniRef50_C9RPT6 Porphobilinogen deaminase n=1 Tax=Fibrobacter su... 303 5e-81 UniRef50_Q6L2G8 Probable porphobilinogen deaminase n=1 Tax=Picro... 303 5e-81 UniRef50_A8PWJ5 Putative uncharacterized protein n=1 Tax=Malasse... 303 7e-81 UniRef50_B2ULP1 Porphobilinogen deaminase n=1 Tax=Akkermansia mu... 302 1e-80 UniRef50_Q5KKQ0 Hydroxymethylbilane synthase, putative n=2 Tax=F... 302 2e-80 UniRef50_C7DH16 Porphobilinogen deaminase n=1 Tax=Candidatus Mic... 301 2e-80 UniRef50_B3LB83 Porphobilinogen deaminase, putative n=1 Tax=Plas... 301 2e-80 UniRef50_D1B7N1 Porphobilinogen deaminase n=1 Tax=Thermanaerovib... 299 8e-80 UniRef50_A6LKX0 Porphobilinogen deaminase n=1 Tax=Thermosipho me... 299 9e-80 UniRef50_A2SQU4 Uroporphyrin-III C-methyltransferase n=11 Tax=Eu... 298 1e-79 UniRef50_C5EV71 Pyruvate ferredoxin/flavodoxin oxidoreductase n=... 298 2e-79 UniRef50_A3VPD5 Porphobilinogen deaminase n=1 Tax=Parvularcula b... 298 2e-79 UniRef50_Q1AUK3 Porphobilinogen deaminase n=1 Tax=Rubrobacter xy... 297 4e-79 UniRef50_C3MZR8 Probable porphobilinogen deaminase n=11 Tax=Sulf... 297 4e-79 UniRef50_C7M2H5 Porphobilinogen deaminase n=1 Tax=Acidimicrobium... 296 8e-79 UniRef50_C7R376 Porphobilinogen deaminase n=1 Tax=Jonesia denitr... 295 1e-78 UniRef50_Q0ATQ1 Porphobilinogen deaminase n=3 Tax=Alphaproteobac... 294 2e-78 UniRef50_A4YD92 Probable porphobilinogen deaminase n=1 Tax=Metal... 294 3e-78 UniRef50_C4JRY9 Porphobilinogen deaminase n=1 Tax=Uncinocarpus r... 294 3e-78 UniRef50_D1JID7 Porphobilinogen deaminase n=1 Tax=uncultured arc... 291 2e-77 UniRef50_A9HK97 Porphobilinogen deaminase n=12 Tax=Acetobacterac... 291 3e-77 UniRef50_B5GJG2 Porphobilinogen deaminase n=3 Tax=Streptomyces R... 289 8e-77 UniRef50_Q2FTK7 Hydroxymethylbilane synthase n=3 Tax=Methanomicr... 289 8e-77 UniRef50_D2RNT2 Porphobilinogen deaminase n=1 Tax=Acidaminococcu... 289 8e-77 UniRef50_C0W553 Porphobilinogen deaminase n=2 Tax=Actinomycetale... 287 4e-76 UniRef50_C8WDJ7 Porphobilinogen deaminase n=3 Tax=Zymomonas mobi... 286 6e-76 UniRef50_Q4PFH9 Putative uncharacterized protein n=1 Tax=Ustilag... 286 7e-76 UniRef50_B4D5X7 Porphobilinogen deaminase n=1 Tax=Chthoniobacter... 282 1e-74 UniRef50_B5JN62 Porphobilinogen deaminase n=1 Tax=Verrucomicrobi... 280 4e-74 UniRef50_A2BFN7 Hydroxymethylbilane synthase (Fragment) n=6 Tax=... 279 8e-74 UniRef50_Q97B26 Probable porphobilinogen deaminase n=2 Tax=Therm... 278 1e-73 UniRef50_Q1GP41 Porphobilinogen deaminase n=7 Tax=Sphingomonadal... 278 2e-73 UniRef50_Q8I5V3 Porphobilinogen deaminase n=6 Tax=Plasmodium Rep... 277 3e-73 UniRef50_C5C5B3 Porphobilinogen deaminase n=6 Tax=Actinomycetale... 277 4e-73 UniRef50_Q9Y9J0 Probable porphobilinogen deaminase n=1 Tax=Aerop... 276 4e-73 UniRef50_C1XV35 Porphobilinogen deaminase n=2 Tax=Meiothermus Re... 275 1e-72 UniRef50_Q93A65 Porphobilinogen deaminase n=1 Tax=uncultured bac... 273 4e-72 UniRef50_Q0RS16 Porphobilinogen deaminase 1 (PBG 1) (Hydroxymeth... 273 5e-72 UniRef50_B0WMK9 Porphobilinogen deaminase n=1 Tax=Culex quinquef... 273 8e-72 UniRef50_Q83H95 Porphobilinogen deaminase n=2 Tax=Tropheryma whi... 268 1e-70 UniRef50_A7BMK1 Porphobilinogen deaminase n=1 Tax=Beggiatoa sp. ... 267 4e-70 UniRef50_UPI000038E213 porphobilinogen deaminase n=1 Tax=Ferropl... 265 1e-69 UniRef50_Q04X38 Bifunctional porphobilinogen deaminase/uroporphy... 261 2e-68 UniRef50_A9V9E0 Predicted protein n=1 Tax=Monosiga brevicollis R... 261 3e-68 UniRef50_UPI0001C31A39 porphobilinogen deaminase n=1 Tax=Conexib... 259 1e-67 UniRef50_A5K0J5 Porphobilinogen deaminase, putative n=1 Tax=Plas... 259 1e-67 UniRef50_B0SF66 Bifunctional porphobilinogen deaminase/uroporphy... 250 4e-65 UniRef50_C0EAN0 Putative uncharacterized protein n=1 Tax=Clostri... 250 6e-65 UniRef50_B1ZV87 Porphobilinogen deaminase n=2 Tax=Opitutaceae Re... 247 4e-64 UniRef50_Q86ET2 Clone ZZD1450 mRNA sequence n=3 Tax=Schistosoma ... 236 6e-61 UniRef50_Q4E9D5 Porphobilinogen deaminase (Fragment) n=1 Tax=Wol... 235 1e-60 UniRef50_Q6MHU0 Hydroxymethylbilane synthase n=1 Tax=Bdellovibri... 232 1e-59 UniRef50_B6YQR9 Hydroxymethylbilane synthase/uroporphyrin-III C-... 225 2e-57 UniRef50_B4UXX3 Porphobilinogen deaminase 2 (Fragment) n=1 Tax=S... 225 2e-57 UniRef50_Q6MEK3 Putative Porphobilinogen deaminase n=2 Tax=Parac... 224 3e-57 UniRef50_A8I2X7 Porphobilinogen deaminase n=1 Tax=Chlamydomonas ... 216 8e-55 UniRef50_Q6Q923 Predicted porphobilinogen deaminase n=2 Tax=envi... 209 1e-52 UniRef50_Q9PK95 Probable porphobilinogen deaminase n=13 Tax=Chla... 201 4e-50 UniRef50_D0RNS6 Putative porphobilinogen deaminase (Pbg)(Hydroxy... 198 2e-49 UniRef50_C5LJF7 Porphobilinogen deaminase, putative n=5 Tax=Perk... 196 9e-49 UniRef50_Q9HMY5 Probable porphobilinogen deaminase n=2 Tax=Halob... 192 1e-47 UniRef50_Q18ES3 Hydroxymethylbilane synthase (Porphobilinogen de... 181 4e-44 UniRef50_B0KCR7 Porphobilinogen deaminase n=3 Tax=Thermoanaeroba... 159 2e-37 UniRef50_UPI000155526F PREDICTED: similar to hydroxymethylbilane... 158 2e-37 UniRef50_C0DZX9 Putative uncharacterized protein n=1 Tax=Coryneb... 156 1e-36 UniRef50_UPI0001B4213A porphobilinogen deaminase n=1 Tax=Listeri... 144 3e-33 UniRef50_A8CBG6 Porphobilinogen deaminase n=3 Tax=Toxoplasma gon... 142 2e-32 UniRef50_UPI0001742E92 Porphobilinogen deaminase n=1 Tax=candida... 129 1e-28 UniRef50_Q1HRH6 Hydroxymethylbilane synthase-like protein n=1 Ta... 118 3e-25 UniRef50_Q401C3 Hydroxymethylbilane synthase (Fragment) n=7 Tax=... 117 6e-25 UniRef50_UPI0001698669 porphobilinogen deaminase n=1 Tax=Endorif... 112 2e-23 UniRef50_B8N6H4 Putative uncharacterized protein n=1 Tax=Aspergi... 100 6e-20 Sequences not found previously or not previously below threshold: UniRef50_UPI0000D9FBB5 PREDICTED: similar to lethal (3) 02640 CG... 95 3e-18 UniRef50_UPI0001C35DE1 porphobilinogen deaminase n=1 Tax=Clostri... 80 1e-13 UniRef50_C5U771 Porphobilinogen deaminase n=1 Tax=Methanocaldoco... 72 3e-11 UniRef50_C5G109 Porphobilinogen deaminase n=1 Tax=Microsporum ca... 72 3e-11 UniRef50_C4Z1K5 Putative uncharacterized protein n=1 Tax=Eubacte... 64 8e-09 UniRef50_Q4EB45 Porphobilinogen deaminase n=1 Tax=Wolbachia endo... 62 2e-08 UniRef50_B5XH53 Porphobilinogen deaminase n=1 Tax=Salmo salar Re... 59 3e-07 UniRef50_C2BR76 Putative uncharacterized protein (Fragment) n=1 ... 58 4e-07 UniRef50_UPI0000D537E6 hypothetical protein P700755_22735 n=1 Ta... 45 0.002 >UniRef50_B7LU53 Porphobilinogen deaminase n=87 Tax=cellular organisms RepID=HEM3_ESCF3 Length = 313 Score = 469 bits (1207), Expect = e-131, Method: Composition-based stats. Identities = 296/312 (94%), Positives = 302/312 (96%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 MLDNVLRIATRQSPLALWQAHYVKD LMA HPGL VELVPMVTRGDVILDTPLAKVGGKG Sbjct: 1 MLDNVLRIATRQSPLALWQAHYVKDALMAKHPGLTVELVPMVTRGDVILDTPLAKVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN Y SLD LP Sbjct: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNKYASLDELP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE Sbjct: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 SRIR ALPPE+SLPAVGQGAVGIECRLDD+RTRELLAALNH ETALRVTAERAMNTRLEG Sbjct: 181 SRIRDALPPEVSLPAVGQGAVGIECRLDDTRTRELLAALNHPETALRVTAERAMNTRLEG 240 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPIGSYAELI GEIWLRALVGAPDGSQ+IRGERRG+PQDAE+MGISLAEELLNNGAR Sbjct: 241 GCQVPIGSYAELIGGEIWLRALVGAPDGSQMIRGERRGSPQDAEKMGISLAEELLNNGAR 300 Query: 301 EILAEVYNGDAP 312 ILA+VYNGDAP Sbjct: 301 AILADVYNGDAP 312 >UniRef50_B5FN93 Porphobilinogen deaminase n=168 Tax=cellular organisms RepID=HEM3_SALDC Length = 313 Score = 461 bits (1186), Expect = e-128, Method: Composition-based stats. Identities = 279/313 (89%), Positives = 294/313 (93%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 MLDNVLRIATRQSPLALWQAHYVKD LMA+HPGL VELVPMVTRGDVILDTPLAKVGGKG Sbjct: 1 MLDNVLRIATRQSPLALWQAHYVKDALMATHPGLTVELVPMVTRGDVILDTPLAKVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKELE+ALLE RADIAVHSMKDVPV FP GLGLVTICEREDPRDAFVSN Y SLD LP Sbjct: 61 LFVKELEIALLEKRADIAVHSMKDVPVAFPDGLGLVTICEREDPRDAFVSNKYHSLDDLP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRL KLDNG+YDAIILAVAGLKRLGLE Sbjct: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLGKLDNGDYDAIILAVAGLKRLGLE 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 SRIR ALPP++SLPAVGQGAVGIECRLDD+RT+ LLA LNH +TALRVTAERAMNTRLEG Sbjct: 181 SRIRTALPPDVSLPAVGQGAVGIECRLDDARTQALLAPLNHSQTALRVTAERAMNTRLEG 240 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPIGSYAE+I+GEIWLRALVGAPDGS ++RGERRG+P+ AEQMGISLAEELL NGAR Sbjct: 241 GCQVPIGSYAEIINGEIWLRALVGAPDGSVMVRGERRGSPEQAEQMGISLAEELLENGAR 300 Query: 301 EILAEVYNGDAPA 313 IL EVYNG+ PA Sbjct: 301 AILTEVYNGETPA 313 >UniRef50_C0QU69 Porphobilinogen deaminase n=4 Tax=Bacteria RepID=C0QU69_PERMH Length = 308 Score = 439 bits (1131), Expect = e-122, Method: Composition-based stats. Identities = 171/304 (56%), Positives = 229/304 (75%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR+S LALWQA+Y+ D+L P L VELV +VT+GD ILD PLAKVGGKGLFVKE Sbjct: 3 IRIGTRKSKLALWQANYIADQLKKHFPDLEVELVKIVTKGDKILDVPLAKVGGKGLFVKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E A+L N DIAVHS+KDVP FP+GLGLV I EREDPRDAF+S Y+S++ +P G+++ Sbjct: 63 IEEAMLRNEIDIAVHSLKDVPTYFPEGLGLVAITEREDPRDAFLSVKYNSIEDMPEGAVL 122 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR+ Q+ +R D+ I LRGNV TR+ KL+ G+YD IILA AGLKRLGLE ++R Sbjct: 123 GTSSLRRKAQIMMKRKDIRIEDLRGNVDTRIRKLEEGQYDGIILAYAGLKRLGLEGKVRQ 182 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L P+ +PAV QG +GIE RLDD +TRE+++ LNH E+ +R AERA LEGGCQVP Sbjct: 183 ILQPDYMIPAVAQGFLGIEARLDDEKTREIVSVLNHRESEIRAKAERAFLKTLEGGCQVP 242 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 + Y+E+++G++ + V G ++ R G+ +DAE +G+ LAE+LL++GA+E+L E Sbjct: 243 LAGYSEIVNGKLKITGFVSDLTGDRVFRDSMEGSLEDAESLGVKLAEKLLSDGAKEVLEE 302 Query: 306 VYNG 309 +Y+G Sbjct: 303 IYSG 306 >UniRef50_Q3ACT3 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=HEM3_CARHZ Length = 311 Score = 434 bits (1116), Expect = e-120, Method: Composition-based stats. Identities = 146/310 (47%), Positives = 202/310 (65%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + + + +R S LALWQ ++V ++L HP + ++V M T+GD ILD LAK+G KGL Sbjct: 1 MKKEVIVGSRDSALALWQTNWVVERLSKIHPEINFKIVTMKTKGDKILDVALAKIGDKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F KELE ALL D+AVHSMKD+P P+GL + CERE P D F+S LP Sbjct: 61 FTKELEHALLNKTIDMAVHSMKDLPTVLPEGLKIGAFCEREYPGDVFISPKGFKFLELPQ 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ +GTSSLRR Q+ RPDL LRGN+ TR K++ + D IILA AG+KRLG E Sbjct: 121 GARIGTSSLRRIAQILAVRPDLQAIPLRGNLPTRFRKMEEMDLDGIILAYAGVKRLGYED 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 +I L ++ LPAVGQG++G+E R DD+ ELL ++H T + AERA RLEGG Sbjct: 181 KITEMLSFDLCLPAVGQGSIGVEIRADDTFIEELLKPIDHFATNRAIRAERAFLKRLEGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 CQ+PIG+Y+E+ + + L+ +V + DG +I+GE+ G+ ++ E++GISLAEELL GA++ Sbjct: 241 CQIPIGAYSEVKENRLHLKGVVASLDGKLVIKGEKEGSIEEPEKVGISLAEELLTKGAQK 300 Query: 302 ILAEVYNGDA 311 IL E+ Sbjct: 301 ILEEIRRDAN 310 >UniRef50_B5YJZ4 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=B5YJZ4_THEYD Length = 311 Score = 432 bits (1112), Expect = e-120, Method: Composition-based stats. Identities = 157/306 (51%), Positives = 218/306 (71%), Gaps = 1/306 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 N + I +R S LA+WQA++VKDKL +P L VE+ + T GD ILD PLAK+GGKGLFV Sbjct: 6 NKIVIGSRGSKLAMWQANWVKDKLQTLYPELKVEIEKIKTTGDKILDAPLAKIGGKGLFV 65 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE+E ALL R D+AVHSMKDVP E P+GL + ICEREDPRDAF+S + L+ LP + Sbjct: 66 KEIEEALLSKRVDLAVHSMKDVPTEIPEGLQISAICEREDPRDAFISKDGVLLNELPQEA 125 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 ++GTSSLRR QL R DL+I+ LRGNV TR+ KL +GE+ AI+LA+AG+KR+G+E+ + Sbjct: 126 VLGTSSLRRTVQLKALRNDLVIKPLRGNVDTRIRKLKDGEFQAIVLAMAGVKRMGVENLV 185 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 A ++ +PA+GQGA+GIE R+DD EL+ LNH ETA+ + AERA + + GGCQ Sbjct: 186 TQAFSEDLMIPAIGQGAIGIETRVDDDFVNELIKPLNHEETAICILAERAFLSVMGGGCQ 245 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQ-IIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 VP+ +A +++ + + ++G P+G +I+G R G+ A+ +G+ LA ELL+ G +EI Sbjct: 246 VPLACHARIVNNSLKIVGMIGDPEGKMPVIKGFREGSLSQAQSLGVELANELLHRGGKEI 305 Query: 303 LAEVYN 308 L +VY Sbjct: 306 LEKVYK 311 >UniRef50_Q0I178 Porphobilinogen deaminase n=45 Tax=Bacteria RepID=HEM3_HAES1 Length = 321 Score = 425 bits (1094), Expect = e-118, Method: Composition-based stats. Identities = 199/318 (62%), Positives = 236/318 (74%), Gaps = 11/318 (3%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 ++ L+IATRQSPLALWQA+YVK++L + L VELVP++T+GDVILDTPLAK+GGKGL Sbjct: 3 INKTLKIATRQSPLALWQANYVKNRLQQRYSHLSVELVPIITKGDVILDTPLAKIGGKGL 62 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKELE ALL ADIAVHSMKDVP++FP+GL L IC REDPRDAFVSN Y +LD LP Sbjct: 63 FVKELENALLNGEADIAVHSMKDVPMQFPKGLELSVICPREDPRDAFVSNKYRTLDELPQ 122 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+IVGTSSLRRQCQL R DL IRSLRGNVGTRL+KLD G+YDAIILA AGL RLGL Sbjct: 123 GAIVGTSSLRRQCQLKNWRADLDIRSLRGNVGTRLNKLDQGDYDAIILASAGLIRLGLTE 182 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 RIR+ + + LPA GQGAVGIECR+DD + LL L T V AERAMN L+GG Sbjct: 183 RIRSFIEIDTILPACGQGAVGIECRVDDRDVQSLLMPLADQTTTYCVLAERAMNFHLQGG 242 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE-----------RRGAPQDAEQMGISL 290 CQVPIG+YA L + +++LR LVG GSQI+ E + A Q AE++G+S+ Sbjct: 243 CQVPIGAYAILENNQLYLRGLVGDVHGSQILSAEGQFELSLDFESSQSAVQKAEELGVSI 302 Query: 291 AEELLNNGAREILAEVYN 308 AE+LL GA +IL VY Sbjct: 303 AEQLLQQGADKILQAVYQ 320 >UniRef50_D1BNZ5 Porphobilinogen deaminase n=3 Tax=Veillonella RepID=D1BNZ5_VEIPT Length = 312 Score = 422 bits (1086), Expect = e-117, Method: Composition-based stats. Identities = 144/305 (47%), Positives = 195/305 (63%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + + +RI TR+S LALWQA ++ +L +P + VELV T+GD IL+ PLA+VGGKGL Sbjct: 1 MRDHIRIGTRKSALALWQAEHISAELQRLYPNITVELVHFNTKGDRILEKPLAQVGGKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F ELE A+ DIAVHS+KD+P E P+GL L I RE P DA VS Y +LD LP Sbjct: 61 FTAELEEAMHAGDIDIAVHSLKDMPTELPEGLTLGAISAREVPYDALVSPVYKTLDKLPQ 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ VGTSSLRRQ QL RPDL + +RGNV TRLSK++ + D +ILA AGLKRLGLE Sbjct: 121 GARVGTSSLRRQAQLLHVRPDLKVEVIRGNVQTRLSKIETEKLDGVILAQAGLKRLGLED 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 +I + +PAVGQGA+ IECR DD+ ++L +N T V ER+ +L GG Sbjct: 181 QITQVFKADEMIPAVGQGALAIECRADDTEMLDMLDPINDEATRYAVEGERSFLRQLNGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 CQVP+G + + G++ L+A++ + DG + GE G + E +G +LA+ L G + Sbjct: 241 CQVPMGVHGTINKGQLTLKAMIASLDGKTVYEGEISGPAKKGEILGKNLAKALYEEGGKR 300 Query: 302 ILAEV 306 I+ + Sbjct: 301 IVDAL 305 >UniRef50_Q8YVU6 Porphobilinogen deaminase n=50 Tax=cellular organisms RepID=HEM3_ANASP Length = 323 Score = 421 bits (1082), Expect = e-116, Method: Composition-based stats. Identities = 151/307 (49%), Positives = 199/307 (64%), Gaps = 3/307 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +RI +R+S LAL Q ++V+++L S P + E+ M T+GD ILD LAK+G KGLF Sbjct: 10 RTIRIGSRKSQLALVQTYWVREQLQNSFPDINFEVHTMSTQGDKILDVALAKIGDKGLFT 69 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALP 120 KELEV ++ D AVHS+KD+P P+GL L I ERE+P DA V + +D LP Sbjct: 70 KELEVGMINEEIDFAVHSLKDLPTNLPEGLALAAITERENPADALVVHENFKDKQIDTLP 129 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 AG+++GTSSLRR QL + P L + +RGN+ TRL+KLD GEYD +ILA AGL+RLG+ Sbjct: 130 AGAVIGTSSLRRLAQLRNQFPHLTFKDVRGNLNTRLAKLDAGEYDGLILAAAGLQRLGMG 189 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R+ LP EISL AVGQGA+GIECR DD+ +L A+ H ET R AER+ LEG Sbjct: 190 DRVHQILPKEISLHAVGQGALGIECRADDAELITVLKAIEHPETRDRCLAERSFLRSLEG 249 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPIG E+ E+ L +V + DG +++ G DAE +GI LAE L GA+ Sbjct: 250 GCQVPIGVNTEINGNELILTGVVASVDGQNLVKDTVSGNASDAEAIGIRLAELLREQGAQ 309 Query: 301 EILAEVY 307 EIL ++ Sbjct: 310 EILNTIF 316 >UniRef50_C0Q9U2 HemC n=2 Tax=Bacteria RepID=C0Q9U2_DESAH Length = 325 Score = 419 bits (1079), Expect = e-116, Method: Composition-based stats. Identities = 146/307 (47%), Positives = 199/307 (64%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + ++I TR S LALWQA++VKD++ P VE++ + T GD+I+D PL+ VGGKGL Sbjct: 19 MKKTIKIGTRGSKLALWQANHVKDRIEDQFPETEVEIMTIKTTGDMIVDRPLSMVGGKGL 78 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKE+E ALLE+ D+AVHSMKD+P E P GL + + RE+P D +SNN SL LP Sbjct: 79 FVKEIEKALLESTIDMAVHSMKDMPGELPPGLVIGAVPARENPFDVLISNNNLSLADLPK 138 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ +GTSSLRR Q+ RPD+ S+RGN+ TRL KL GE+DA +LA AGL RLG+++ Sbjct: 139 GARIGTSSLRRASQIKHARPDIETASIRGNLDTRLKKLAAGEFDATLLAAAGLIRLGMKT 198 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 I I +PAVGQGA+ IE R +D +LA LNH ET V+ ERA RL+G Sbjct: 199 VITQYFDETIMIPAVGQGALCIESRQEDLDIAPVLAFLNHGETHTVVSGERAFLRRLDGS 258 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 C +P+ + L D + L LV + DG I++ G P+D ++ GI+LAE LL+ GA + Sbjct: 259 CHIPVACFGRLEDHRVILTGLVASEDGRTILKETVAGTPEDPQKAGIALAETLLSKGADK 318 Query: 302 ILAEVYN 308 IL + + Sbjct: 319 ILENLNS 325 >UniRef50_A1AUE7 Porphobilinogen deaminase n=44 Tax=Bacteria RepID=HEM3_PELPD Length = 310 Score = 412 bits (1061), Expect = e-114, Method: Composition-based stats. Identities = 167/308 (54%), Positives = 203/308 (65%), Gaps = 1/308 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M LRI TR S LALWQA++VK +L +P + V L + T GD ILD PLA+VGGKG Sbjct: 1 MPPRQLRIGTRASQLALWQANWVKSELEKRYPAMEVTLTKIKTMGDRILDVPLAQVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E A+L DIAVHSMKDVP EFP+GLGL I EREDPRDA VS LP Sbjct: 61 LFVKEIEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVVSRAAR-FSHLP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGTS+LRRQ QL RPDL + ++RGNV TR+ KLD DA+ILA AGLKRLGL Sbjct: 120 PGARVGTSALRRQAQLLHARPDLEMVTIRGNVETRIRKLDEENLDAVILAAAGLKRLGLT 179 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R+ L E S+PA+GQGA+GIECRL D E +A NH +T+ V AERA+ R +G Sbjct: 180 QRVAEYLDVEFSIPAIGQGALGIECRLSDPVVTEAIAFFNHPDTSHAVRAERALLRRCQG 239 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPI ++ + GE+ L L+ A DG + +R E G E +G LA+ LL+ G R Sbjct: 240 GCQVPIAAHGTIRGGELRLVGLIAAVDGREFVRDEISGPVDQCEHLGEELADRLLSRGGR 299 Query: 301 EILAEVYN 308 IL EVY Sbjct: 300 AILEEVYQ 307 >UniRef50_Q8DIE4 Porphobilinogen deaminase n=11 Tax=cellular organisms RepID=HEM3_THEEB Length = 320 Score = 411 bits (1057), Expect = e-113, Method: Composition-based stats. Identities = 151/314 (48%), Positives = 199/314 (63%), Gaps = 3/314 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 +RI +R+S LAL Q +V+ +L H E+V M T+GD ILD LAK+G KGL Sbjct: 5 SSRPVRIGSRKSQLALVQTEWVQAQLQTHHRDRAFEVVTMTTQGDNILDVALAKIGDKGL 64 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDA 118 F KELE+++L D+AVHS+KD+P + P GL L I EREDP DA V ++D Sbjct: 65 FTKELELSMLRGETDLAVHSLKDLPTQLPDGLVLAAITEREDPADALVLGAKWTGHTIDT 124 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 LP G+++GTSSLRR QL P L + +RGN+ TRL+KLD GEYDA+ILAVAGL+RLG Sbjct: 125 LPEGTVIGTSSLRRLAQLRHYYPHLTFKDVRGNLNTRLAKLDAGEYDALILAVAGLRRLG 184 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 RI LP +SL AVGQGA+GIECR +D+ L+ L H ET R AERA +L Sbjct: 185 FGDRISQVLPATVSLYAVGQGALGIECRAEDADILALVKTLEHPETTARCLAERAFLRQL 244 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 EGGCQVPIG + + +G++ L LV + DG ++++ G AE++G LA +L G Sbjct: 245 EGGCQVPIGVHTVIENGQLTLTGLVASLDGQRLVKDSLTGDVATAEELGTRLALKLREQG 304 Query: 299 AREILAEVYNGDAP 312 A EIL E++ P Sbjct: 305 ASEILEEIFATVRP 318 >UniRef50_B5EBG8 Porphobilinogen deaminase n=166 Tax=Bacteria RepID=HEM3_GEOBB Length = 318 Score = 409 bits (1053), Expect = e-113, Method: Composition-based stats. Identities = 158/308 (51%), Positives = 204/308 (66%), Gaps = 1/308 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M LRI TR S LALWQA++VK +L +P + V L + T GD ILD PLA+VGGKG Sbjct: 1 MALKELRIGTRASQLALWQANWVKSELEKRYPDMTVTLTKIKTIGDKILDVPLAQVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E A+L DIAVHSMKDVP EFP+GLGL I EREDPRDA +SN LP Sbjct: 61 LFVKEIEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVISN-GVKFADLP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GTS+LRRQ QL + RPDL + +RGNV TR+ KL DA+ILA AGL RLG Sbjct: 120 QGARIGTSALRRQAQLLKVRPDLEMVIIRGNVQTRMDKLKTEGLDAVILAAAGLNRLGFA 179 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 +I LP ++SLPA+GQGA+GIEC L + ++ ++ N +T+ V AERA+ R EG Sbjct: 180 DQITEMLPTDLSLPAIGQGALGIECNLSNQDVKDAISFFNSPDTSRAVRAERALLWRCEG 239 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPI ++ E+ ++ L + + DG ++G G D E++G+ LAE+LL+ G Sbjct: 240 GCQVPIAAFGEVTGDQLKLTGFIASVDGKVSVKGVVTGPADDCEKLGVKLAEQLLSEGGH 299 Query: 301 EILAEVYN 308 ILAEVY Sbjct: 300 AILAEVYQ 307 >UniRef50_C9KL85 Hydroxymethylbilane synthase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KL85_9FIRM Length = 315 Score = 409 bits (1053), Expect = e-113, Method: Composition-based stats. Identities = 162/307 (52%), Positives = 201/307 (65%), Gaps = 1/307 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M ++ + I TR S LALWQA YV D L +P L VE M T+GD ILD PLAK+GGKG Sbjct: 1 MKNDTIVIGTRSSKLALWQADYVADCLRKRYPELRVEKKLMTTKGDKILDAPLAKIGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF KELE +L DIAVHS+KD+P E P+GL + I ER DP DA VS Y +L+ LP Sbjct: 61 LFTKELEQDMLAGGIDIAVHSLKDMPTEVPEGLVISAITERFDPGDAVVSPKYRTLENLP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGTSSLRR+ QL RPDL I LRGNV TRL KL+ +DAIILAVAGLKRLG Sbjct: 121 QGAKVGTSSLRRKAQLLHARPDLQISDLRGNVNTRLEKLEREHFDAIILAVAGLKRLGFA 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 RI LP E+ LPAVGQGA+ IE R +D R L+A LN T AERA R+EG Sbjct: 181 DRITEVLPREMVLPAVGQGALAIETRENDREVRNLIAFLNDEATVACARAERAFLARVEG 240 Query: 241 GCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GCQVP+G YA +G + + A++ + DG+++ R G+ +AE +G +LA++LL G Sbjct: 241 GCQVPVGVYAVPEAEGRLHVEAVIASLDGARLYRDAAVGSAAEAESLGTALADKLLAMGG 300 Query: 300 REILAEV 306 IL E+ Sbjct: 301 IAILHEI 307 >UniRef50_A6TJD5 Porphobilinogen deaminase n=2 Tax=Firmicutes RepID=HEM3_ALKMQ Length = 316 Score = 409 bits (1051), Expect = e-112, Method: Composition-based stats. Identities = 139/307 (45%), Positives = 191/307 (62%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 ++I +R S LAL QA + + L P E++ + T GD ILD L K+GGKGLFV Sbjct: 2 RTIKIGSRASQLALVQAEIIINMLKEKFPQYTYEIIKITTLGDRILDKTLDKIGGKGLFV 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE++ AL E + D+A+HSMKD+P E P+ L L I +REDPRD ++ SL+ LP G+ Sbjct: 62 KEIQKALAEEKIDLAIHSMKDMPGETPEELVLGAITKREDPRDVLITRENKSLEELPKGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 ++G+SSLRRQ Q+ R D+ + +RGNVGTRL K++ D +ILA AGL RLGL+ +I Sbjct: 122 VIGSSSLRRQAQVMALRGDIKVVPIRGNVGTRLGKIETESLDGVILAAAGLNRLGLKEKI 181 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + L E PAVGQGA+G E R D E+L A+NH ET V AERA LEGGC Sbjct: 182 SSYLEIEDFTPAVGQGALGCEARRKDIEMLEMLLAINHEETYRCVMAERAFLKLLEGGCH 241 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 VPIG+Y + E+ + +V + DG ++I+ + G D + +GI L E L+ GA+EIL Sbjct: 242 VPIGAYGQQQGQELHMTGMVASSDGRRVIKEQVMGDIADFQALGIQLGETLIEKGAKEIL 301 Query: 304 AEVYNGD 310 V + Sbjct: 302 ETVNTDN 308 >UniRef50_Q65GK1 Porphobilinogen deaminase n=98 Tax=Bacillales RepID=HEM3_BACLD Length = 313 Score = 408 bits (1049), Expect = e-112, Method: Composition-based stats. Identities = 143/305 (46%), Positives = 188/305 (61%), Gaps = 4/305 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 + + +R+S LA+ Q +V KL +P E+ +VT+GD ILD L+KVGGKGLFVKE Sbjct: 4 IIVGSRRSKLAMTQTKWVIKKLEELNPDFTFEIKEIVTKGDRILDVTLSKVGGKGLFVKE 63 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E A+L D+AVHSMKD+P P+GL + I +RED RD +S L L G++V Sbjct: 64 IEQAMLSGEIDMAVHSMKDMPSVLPEGLMVGCIPKREDARDVLISKGRQKLADLKQGAVV 123 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL-ESRIR 184 GTSSLRR QL + RPDL I+ +RGN+ TRL KL+ +YDAIILA AGL R+G + + Sbjct: 124 GTSSLRRSAQLLQMRPDLEIKWIRGNIDTRLKKLETEDYDAIILAAAGLSRMGWKDDVVT 183 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L PE LPAVGQGA+ IECR D L + LN T L VTAERA +EGGCQV Sbjct: 184 EFLDPESCLPAVGQGALAIECRGSDEELLSLFSRLNDRYTQLTVTAERAFLHAMEGGCQV 243 Query: 245 PIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 PI +A++ DG I L LV +PDG + R +G +D E +G A + GA+ ++ Sbjct: 244 PIAGFAKMDEDGVIELTGLVASPDGKTVYRETVKG--KDPEAVGRECAAVMSEKGAKALI 301 Query: 304 AEVYN 308 V Sbjct: 302 DRVKQ 306 >UniRef50_Q31PM2 Porphobilinogen deaminase n=8 Tax=cellular organisms RepID=HEM3_SYNE7 Length = 320 Score = 400 bits (1029), Expect = e-110, Method: Composition-based stats. Identities = 151/312 (48%), Positives = 200/312 (64%), Gaps = 3/312 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +RI +R+S LAL Q H+V+ +L +P ++ M T+GD+ILD LAK+G KGLF Sbjct: 7 RPIRIGSRKSQLALVQTHWVQGELQRLYPDRQFDVQTMSTQGDIILDVALAKIGDKGLFT 66 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALP 120 KELEVA+L D AVHS+KD+P P+GL L + EREDP DA V + L+ LP Sbjct: 67 KELEVAMLAGEVDFAVHSLKDLPTRLPEGLILGCVTEREDPADALVVHDRFKDHQLETLP 126 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+++GTSSLRR QL P L + +RGN+ TRL+KLD GEYDA+ILA AGL+RL + Sbjct: 127 EGTVIGTSSLRRLAQLRHHYPHLQFKDVRGNLNTRLAKLDAGEYDALILAAAGLQRLSMA 186 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 RI +P +SL AVGQGA+GIECR +D ELL AL H T+ R AERA LEG Sbjct: 187 DRIHQLIPAAVSLHAVGQGALGIECRAEDPEILELLKALEHEPTSQRCLAERAFLRELEG 246 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPIG + DG + L +V + DG +++R + G D E +G++LA +L GA+ Sbjct: 247 GCQVPIGVNTAIADGTLTLTGMVASLDGQRLLRDQVSGPTSDPEALGLALAAQLKAQGAK 306 Query: 301 EILAEVYNGDAP 312 EIL E++ P Sbjct: 307 EILDEIFATVRP 318 >UniRef50_Q5ZRY6 Porphobilinogen deaminase n=6 Tax=Legionella RepID=HEM3_LEGPH Length = 309 Score = 397 bits (1022), Expect = e-109, Method: Composition-based stats. Identities = 153/309 (49%), Positives = 205/309 (66%), Gaps = 1/309 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M ++RIATRQSPLALWQA++V++ L+ P L +EL+PM+T GD L L GGKG Sbjct: 1 MSAKIIRIATRQSPLALWQANHVREMLVKQWPNLSIELLPMITSGDRFLKDKLLSAGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKELE ALL+ RAD+AVHS KD+P + P GL L IC+R++P DA +S + SL ALP Sbjct: 61 LFVKELEEALLDKRADLAVHSTKDMPAQLPDGLLLTAICKRDNPFDALISPQFKSLAALP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 +I+GTSSLRRQ QL P+L I++LRGN+ TRLSKL++GEY AIILA AGL+R+GL Sbjct: 121 KNAIIGTSSLRRQSQLLAYNPNLQIKTLRGNIHTRLSKLESGEYQAIILAAAGLERMGLA 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 I +P +I LP QGA+ IECR DD +EL+ LN +AL V ER +N +L G Sbjct: 181 HHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELVHGLNDPISALCVHTERRVNAKLGG 240 Query: 241 GCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 C +P Y + + + + LRA V DGSQ+I E++G +AE + E L+ GA Sbjct: 241 NCHIPFAVYCTITEEKLLLLRAKVLNMDGSQMIDDEQQGKIAEAEVIADRCTESLMTKGA 300 Query: 300 REILAEVYN 308 +L+ + + Sbjct: 301 MSLLSTIPS 309 >UniRef50_C6HUG2 Porphobilinogen deaminase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HUG2_9BACT Length = 321 Score = 397 bits (1022), Expect = e-109, Method: Composition-based stats. Identities = 156/305 (51%), Positives = 205/305 (67%), Gaps = 2/305 (0%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + +RI TR S LALWQA +V + GL EL + T GD+IL PL++VGGKGLF Sbjct: 7 SSPIRIGTRGSELALWQARHVAAMIR-HTAGLESELTIIKTTGDMILSVPLSQVGGKGLF 65 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 VKE+E AL+ D+AVHSMKDVP P+GL + I REDPRDAFVSN Y S +LP G Sbjct: 66 VKEIEEALIAGTIDLAVHSMKDVPAFLPEGLEIGAILSREDPRDAFVSNAYSSFSSLPPG 125 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 + +GTSSLRR QL +RRPDL SLRGNVGTRL KLD + DAIILA AGL RLG R Sbjct: 126 ARIGTSSLRRMAQLKKRRPDLRFESLRGNVGTRLRKLDENQIDAIILAAAGLIRLGFSDR 185 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 IR LP E+SLPAVGQGA+G+ECR D R R +LA ++ ET V AER + + L+GGC Sbjct: 186 IREYLPVELSLPAVGQGALGLECRTGDHRIRTILARMHDPETTACVLAERGVLSALDGGC 245 Query: 243 QVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 Q+PI ++A + +I L A + +G+ ++ G ++A ++G+ A++LL+ G ++ Sbjct: 246 QLPIAAHARTISPEQIELIARILDVEGTTLLEEHTSGPAKEAHRLGVEAAQKLLSRGGQK 305 Query: 302 ILAEV 306 IL ++ Sbjct: 306 ILTDI 310 >UniRef50_B2A1G7 Porphobilinogen deaminase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=HEM3_NATTJ Length = 311 Score = 397 bits (1020), Expect = e-109, Method: Composition-based stats. Identities = 137/309 (44%), Positives = 195/309 (63%), Gaps = 5/309 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LRI TR+S LAL Q ++V ++L +P + +E+ + T+GD +L+ L+KVGGKGLF+KE Sbjct: 3 LRIGTRRSQLALDQTNWVVEQLKTHYPDIEIEIKKIETKGDQLLNVSLSKVGGKGLFLKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 ++ ALL+ D+AVHSMKD+P E + L + I +R DP DA +SNN ++D LP + + Sbjct: 63 IQNALLQGEIDLAVHSMKDIPTETTEDLEICAITKRVDPLDALISNNDITIDELPENAKI 122 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESRIR 184 GTSSLRR QL R DL I +RGN+ TR++KL E DA++LA AGL R G+ I Sbjct: 123 GTSSLRRGSQLKAYRNDLQIIPIRGNINTRMNKLQELPELDAVVLAKAGLVRSGMTDSIS 182 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 + PEI +P GQGA+G+E R D+ +E LA L+ E+ + AERA RL G C V Sbjct: 183 QNISPEIIVPCPGQGALGLEIRHDNENLKEKLAVLDDSESRKAIGAERAFLNRLGGSCHV 242 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD----AEQMGISLAEELLNNGAR 300 P+G+YAE+I E+ L +V + DG +I+ + D +G LAEEL+ GA Sbjct: 243 PVGAYAEIISNELHLTGVVASEDGQDVIKRSVQTHLSDNNKIPSTLGNDLAEELIELGAN 302 Query: 301 EILAEVYNG 309 +IL+E+ G Sbjct: 303 KILSELKEG 311 >UniRef50_Q2RJ26 Porphobilinogen deaminase n=5 Tax=Clostridia RepID=HEM3_MOOTA Length = 313 Score = 396 bits (1019), Expect = e-109, Method: Composition-based stats. Identities = 150/302 (49%), Positives = 193/302 (63%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +++ +R+S LA WQA +V L + PGL LV + T+GD ILD LA++G KGLF KE Sbjct: 4 IKVGSRESELARWQARWVIQALEKAWPGLSCRLVTLKTKGDKILDVALARIGDKGLFTKE 63 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE+ALL+ D+AVHSMKD+P P+GL + I REDP D VS +L LP + V Sbjct: 64 LELALLDGAIDLAVHSMKDMPTTLPEGLVIGAIGPREDPADVLVSPEGYTLATLPIKARV 123 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR+ QLA RPDL + LRGNV TRL+K++ AI+LA AGLKRL + Sbjct: 124 GTSSLRRKAQLAYARPDLELVDLRGNVPTRLAKMERDGLTAIVLAAAGLKRLNHGQVLGE 183 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 +P I LPAVGQGA+G+E R D R EL+AA+NH TA V AERA LEGGCQVP Sbjct: 184 PIPYHICLPAVGQGAIGVEIRAGDRRVAELVAAINHPPTAAAVRAERAYLRALEGGCQVP 243 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 I + A + D + L+ +V + DG +++R G+ +D E G LA +LL GA EIL E Sbjct: 244 IAALATVEDTALVLQGMVASLDGREMLRDIASGSTRDPEAAGRELARKLLARGAGEILQE 303 Query: 306 VY 307 V Sbjct: 304 VK 305 >UniRef50_Q30Y29 Porphobilinogen deaminase n=13 Tax=Bacteria RepID=HEM3_DESDG Length = 316 Score = 391 bits (1006), Expect = e-107, Method: Composition-based stats. Identities = 167/311 (53%), Positives = 210/311 (67%), Gaps = 3/311 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPG-LVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + IATR S LALWQA ++K+++M +P VEL+ + T+GD+ILD PLAKVGGKGLF Sbjct: 2 KKIVIATRGSKLALWQAEHIKERIMQQYPDSFEVELLVLKTKGDIILDVPLAKVGGKGLF 61 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 VKE+E ALL+ RADIAVHSMKDVP+E PQGL L I ERE P D+ +S YD LDALP G Sbjct: 62 VKEIEEALLDGRADIAVHSMKDVPMELPQGLTLGAIPEREVPTDSLLSARYDGLDALPQG 121 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 ++VGTSSLRRQ Q+ RPDL ++ LRGNV TR+ KL +GEYDAII+A +GLKRLG + Sbjct: 122 AVVGTSSLRRQSQILAMRPDLEVKWLRGNVQTRIRKLMDGEYDAIIMATSGLKRLGETAP 181 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 + L P + +PAVGQGA+G+E R D E+LA L+H + + V AER L+GGC Sbjct: 182 FHSELGPPLFMPAVGQGALGLEYRSDRQDLAEMLAFLDHRPSRICVEAERGFLFGLQGGC 241 Query: 243 QVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 QVPI YA + D L LV DG+ +IR G DA G++LA ++ GA Sbjct: 242 QVPIAGYAVMTGDNSFELTGLVAELDGTAVIRRTAAGTEADARDTGLTLAAQVKAAGADA 301 Query: 302 ILAEVY-NGDA 311 IL VY NG A Sbjct: 302 ILQRVYENGHA 312 >UniRef50_B3QWI1 Porphobilinogen deaminase n=12 Tax=Chlorobiaceae RepID=HEM3_CHLT3 Length = 314 Score = 390 bits (1004), Expect = e-107, Method: Composition-based stats. Identities = 144/314 (45%), Positives = 195/314 (62%), Gaps = 4/314 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + L I TR SPLALWQA ++K +L +P L + L + T GD ILD PLAK+G KGL Sbjct: 1 MKKALIIGTRSSPLALWQAEFIKAELSKHYPSLDISLRHIKTTGDKILDAPLAKIGDKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F +E+E +L N D+AVHS+KD+P E P+GL + I ERED RD +S +L LP Sbjct: 61 FTREIEHVMLRNEIDLAVHSLKDLPTETPEGLVITAITEREDNRDVLISKGKYTLKTLPQ 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+IV TSSLRR+ QL RPDL + +RGN+ TR + + G+ +A++LA AG+ RL Sbjct: 121 GAIVATSSLRRRSQLLHLRPDLEVIDMRGNLNTRFKRFEEGDAEAMLLAFAGVHRLEFSE 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 I + + LPAVGQGA+GIE R+DD TRELL LNH ET L ER++ LEGG Sbjct: 181 HIAEIISFDDILPAVGQGALGIETRIDDEETRELLKVLNHAETELCTKCERSLLRTLEGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR----GAPQDAEQMGISLAEELLNN 297 CQ+PIG++A + +G VG+ DG + I+ ++AEQ+GI +A+ Sbjct: 241 CQIPIGAHARIENGTFHFATYVGSIDGKRAIKKSLSRENVTTVEEAEQIGIEVADAARAA 300 Query: 298 GAREILAEVYNGDA 311 GA EIL E+ +A Sbjct: 301 GANEILCEIRTDNA 314 >UniRef50_C9R7U0 Porphobilinogen deaminase n=1 Tax=Ammonifex degensii KC4 RepID=C9R7U0_AMMDK Length = 308 Score = 390 bits (1003), Expect = e-107, Method: Composition-based stats. Identities = 144/303 (47%), Positives = 186/303 (61%), Gaps = 1/303 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 LRI TR S LAL Q V L P E+V + T GD + + L ++GGKGL Sbjct: 4 SKRCLRIGTRGSDLALAQTEQVLQILRERWPHYTYEIVKIKTTGDKVRNLALPRIGGKGL 63 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F KELEVALLE + D+AVHS+KD+P E P+ L + + RE P D +S L+ LP Sbjct: 64 FTKELEVALLEEKIDLAVHSLKDLPTELPEELCVGAVLPREHPGDVLISLTGAGLEDLPE 123 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ +GTSSLRRQ QL RPDL LRGNV TRL KL+ GE +A++LA AGL+RL L+ Sbjct: 124 GARIGTSSLRRQAQLKAARPDLNFVPLRGNVPTRLRKLEKGECEAVVLAWAGLRRLRLDL 183 Query: 182 RIRA-ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R LP ++ LPAV QGA+G+E R +D R+++ L+ T L VTAERA L G Sbjct: 184 TGRMTLLPYQVCLPAVAQGAIGVEMRKEDRELRKMVEVLDDPTTRLEVTAERAFLRWLGG 243 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GC VPI + A + EI L LV P+G +I+RG+ G+ E++GI LAE LL GA Sbjct: 244 GCHVPIAALARVAGAEILLEGLVADPEGKRIVRGQESGSTAYPEEVGIRLAERLLREGAE 303 Query: 301 EIL 303 E+L Sbjct: 304 ELL 306 >UniRef50_P08397 Porphobilinogen deaminase n=59 Tax=Chordata RepID=HEM3_HUMAN Length = 361 Score = 389 bits (1001), Expect = e-107, Method: Composition-based stats. Identities = 145/334 (43%), Positives = 191/334 (57%), Gaps = 33/334 (9%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 V+R+ TR+S LA Q V L AS+PGL E++ M T GD ILDT L+K+G K LF Sbjct: 19 RVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFT 78 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALP 120 KELE AL +N D+ VHS+KD+P P G + IC+RE+P DA V + +L+ LP Sbjct: 79 KELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLP 138 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGL 179 S+VGTSSLRR QL + P L RS+RGN+ TRL KLD E+ AIILA AGL+R+G Sbjct: 139 EKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQEFSAIILATAGLQRMGW 198 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 +R+ L PE + AVGQGA+G+E R D +L+ L+ ET LR AERA LE Sbjct: 199 HNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLE 258 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-----------GAPQD------ 282 GGC VP+ + + DG+++L V + DGS I+ + G D Sbjct: 259 GGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIHVPAQHEDGPEDDPQLVGI 318 Query: 283 ------------AEQMGISLAEELLNNGAREILA 304 A+ +GISLA LL+ GA+ IL Sbjct: 319 TARNIPRGPQLAAQNLGISLANLLLSKGAKNILD 352 >UniRef50_B3E2H7 Porphobilinogen deaminase n=3 Tax=Proteobacteria RepID=HEM3_GEOLS Length = 312 Score = 388 bits (998), Expect = e-106, Method: Composition-based stats. Identities = 161/308 (52%), Positives = 206/308 (66%), Gaps = 1/308 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M LRI TR S LALWQA++ K +L A +PG+ VELV + T GD ILD PLA+VGGKG Sbjct: 1 MAPKRLRIGTRASQLALWQANWTKSELEARYPGIQVELVKIKTMGDKILDVPLAQVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E A+L D+AVHSMKDVP EFP+GLGLV +REDPRDAF+S + + L Sbjct: 61 LFVKEIEEAMLRGEIDLAVHSMKDVPTEFPEGLGLVVTTKREDPRDAFIS-DKVTFSELR 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GTS+LRRQ QL + RPDL + +RGNV TR+ KL DA+ILA AGL RLG Sbjct: 120 QGARIGTSALRRQAQLLKARPDLEMVIIRGNVETRIRKLKEDNLDAVILAAAGLNRLGFT 179 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 + L + S+PA+GQGA+G+ECRLDD+ T E LA LNH +TA V AERA+ R EG Sbjct: 180 DVVTELLDTDFSIPAIGQGALGLECRLDDNATIEALAFLNHADTAAAVAAERALLKRCEG 239 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPI ++ + + L + + DG Q +R G+ DA ++G LA+ LL G + Sbjct: 240 GCQVPIAAHGTVSGDTLTLVGFIASVDGKQTVRDRISGSTADAVKLGTELADRLLAAGGK 299 Query: 301 EILAEVYN 308 IL +VY Sbjct: 300 AILEDVYQ 307 >UniRef50_Q54P93 Porphobilinogen deaminase n=1 Tax=Dictyostelium discoideum RepID=HEM3_DICDI Length = 325 Score = 386 bits (992), Expect = e-106, Method: Composition-based stats. Identities = 132/316 (41%), Positives = 191/316 (60%), Gaps = 12/316 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 + I +R+S LA+ Q +V+D++ +PG++VE+ M T GD +LD L+K+G KGLF KE Sbjct: 10 VIIGSRKSQLAMLQTEWVRDRIQELNPGIIVEIKTMDTTGDKVLDVSLSKIGDKGLFTKE 69 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD-----SLDALP 120 LE +L D+AVHS+KD+P + P GL L I +R + DAF++N L LP Sbjct: 70 LEDMMLNGTIDLAVHSLKDIPTKLPDGLKLGAITKRYNTSDAFIANAKKHGKNCKLSELP 129 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--DNGEYDAIILAVAGLKRLG 178 G+++G+SSLRR QL + P L + +RGN+ TR KL D+ YD +ILAVAGL+R+ Sbjct: 130 QGAMIGSSSLRRVAQLKKAYPHLQFKDIRGNLNTRFKKLEDDSNGYDGMILAVAGLERME 189 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 L I +P ISL AVGQG++GIEC+ D + +L L H E+ AER+M L Sbjct: 190 LTDHISEIIPDSISLYAVGQGSLGIECKDGDDFIQSILNPLIHRESMYCCEAERSMLRDL 249 Query: 239 EGGCQVPIGSYAEL-----IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEE 293 EGGC VPIG +L D + + A+V DGS+ I + G Q+G S+A++ Sbjct: 250 EGGCHVPIGVVTKLHNQSQPDETLEINAIVLNLDGSKYIESKIIGPSIQYYQLGKSIAQD 309 Query: 294 LLNNGAREILAEVYNG 309 L+N G+++IL+E Sbjct: 310 LINKGSKDILSEFIKK 325 >UniRef50_Q2LQU2 Porphobilinogen deaminase n=1 Tax=Syntrophus aciditrophicus SB RepID=HEM3_SYNAS Length = 306 Score = 384 bits (988), Expect = e-105, Method: Composition-based stats. Identities = 131/304 (43%), Positives = 186/304 (61%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 ++I TR S LAL Q + +L +P + +E+V + T GD+ D PLAK+GGKGLF+KE Sbjct: 1 MKIGTRGSALALTQTRQIAARLQGQYPEMHLEIVVIKTSGDIQKDVPLAKIGGKGLFIKE 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E ALL D+AVHSMKD+P E P+GL + + REDPRD +S D LPAG+ + Sbjct: 61 IEEALLAGTVDLAVHSMKDLPAELPEGLQIAAVPRREDPRDVLISGICREFDNLPAGARI 120 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT SLRR QL + RPDL I LRGN+ TR+ K+ D +++A AG++R+G ++ Sbjct: 121 GTGSLRRSVQLRDWRPDLEIVPLRGNLDTRIRKVAQAALDGVVVAAAGIRRMGWAEKVTQ 180 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 +P E LPAVGQG + +E R +D + LA L T VTAERA RL GGC +P Sbjct: 181 FIPTEKMLPAVGQGVLCLETREEDEDLKAGLAFLEDKRTRREVTAERAFLRRLGGGCTLP 240 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 + ++AE + +R +VG+ + +IR E G+ + A +G LAE LL+ G R +L Sbjct: 241 VAAFAEQRGDVLTIRGMVGSLNERTMIRQEIYGSVEQAVDLGTELAERLLDGGGRILLEH 300 Query: 306 VYNG 309 + +G Sbjct: 301 LEDG 304 >UniRef50_Q4L709 Porphobilinogen deaminase n=88 Tax=Bacillales RepID=HEM3_STAHJ Length = 310 Score = 384 bits (986), Expect = e-105, Method: Composition-based stats. Identities = 139/310 (44%), Positives = 196/310 (63%), Gaps = 4/310 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L + +R+S LAL Q+ DKL A P L +E+ +VT+GD I++ L+KVGGKGLFV Sbjct: 2 RKLVVGSRRSKLALTQSQQFIDKLKAVDPTLEIEIKEIVTKGDRIVNKQLSKVGGKGLFV 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE++ L + D+A+HS+KDVP P+GL L I +RE P DA++S N+ L+ LP GS Sbjct: 62 KEIQQELFDKEIDMAIHSLKDVPSIIPEGLTLGCIPDREVPFDAYISKNHIPLNELPDGS 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 I+GTSSLRR Q+ + P+L I+ +RGN+ TRL KL+ +YDAIILA AGL+R+G I Sbjct: 122 IIGTSSLRRGAQILSKYPNLEIKWIRGNIDTRLKKLEIEDYDAIILAAAGLRRMGWSDDI 181 Query: 184 -RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 L +I LPA+GQGA+GIECR DD ELL+ +++ A VTAER + ++G C Sbjct: 182 VTTYLDKDILLPAIGQGALGIECRSDDVELLELLSKVHNQAVANCVTAERTFLSAMDGSC 241 Query: 243 QVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 QVPIG YA +GEI L+ PDG++ G ++ +G +++ L GA E Sbjct: 242 QVPIGGYATNKENGEIEFTGLIMTPDGTKRYEHTEVG--KNPVDLGEAVSRVLKEQGAYE 299 Query: 302 ILAEVYNGDA 311 I+ ++ A Sbjct: 300 IIKKLNEEQA 309 >UniRef50_A8PKX6 Porphobilinogen deaminase n=2 Tax=Gammaproteobacteria RepID=A8PKX6_9COXI Length = 311 Score = 382 bits (981), Expect = e-104, Method: Composition-based stats. Identities = 152/306 (49%), Positives = 194/306 (63%), Gaps = 2/306 (0%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 LRIATR+SPLA WQA +K++L P L + L+P VT GD L + GGKGLF Sbjct: 4 KKFLRIATRKSPLAYWQATSIKNQLEKIFPFLKITLLPFVTEGDR-PSHSLNQWGGKGLF 62 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 VKELE ALL +ADIAVHS+KD+P+ +GL L IC+R DPRD +S + LP G Sbjct: 63 VKELEAALLHGQADIAVHSLKDLPMTLEKGLVLGAICKRCDPRDVLISRSDRLFTQLPPG 122 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 S VGTSSLRRQ QL RPDL I LRGN+GTRL+KL GE+DAIILA AGL RL Sbjct: 123 SYVGTSSLRRQSQLLALRPDLKIGVLRGNIGTRLNKLAAGEFDAIILAAAGLIRLKKTEC 182 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 I + LPA GQGA+GIEC +D + ++AL H T V AERA++ L GGC Sbjct: 183 ISEYFEIDHFLPAPGQGALGIECHENDEESLTYISALIHPITHSCVLAERALSRELGGGC 242 Query: 243 QVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 QVP+ +YA + + I L+A VG+ DG+ I+ E++G +AE++G A++L G E Sbjct: 243 QVPLAAYAASLGQDFIRLQAFVGSSDGTTQIKVEKQGPRVEAEKIGFLAAQDLRALGVEE 302 Query: 302 ILAEVY 307 IL + Sbjct: 303 ILNKFK 308 >UniRef50_A7NKU8 Porphobilinogen deaminase n=5 Tax=Bacteria RepID=HEM3_ROSCS Length = 303 Score = 380 bits (978), Expect = e-104, Method: Composition-based stats. Identities = 152/303 (50%), Positives = 195/303 (64%), Gaps = 1/303 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + N L I TR S LAL Q H ++D L A+HPGL V + + TRGD+ILD PL +G KGL Sbjct: 1 MRNSLTIGTRASKLALVQTHMIRDALQAAHPGLTVAVERITTRGDIILDRPLNAIGDKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FV E+E A+ R D+AVHS KD+P P + L R DPRDA V+ +L +LP Sbjct: 61 FVVEIEEAMRAGRVDLAVHSAKDLPSTLPPDMTLAVCPRRADPRDALVAQPGMTLASLPH 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ VGTSSLRR CQL RPDL + LRGNV TRL KL G+YDAI+LA AGLKRLGLE Sbjct: 121 GARVGTSSLRRACQLRALRPDLTLLDLRGNVDTRLRKLREGQYDAIVLAAAGLKRLGLEE 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 I L P++ +PAVGQG +G+E R D LLA L+ +TAERA R+ GG Sbjct: 181 VITELLEPDVLIPAVGQGIIGVEARAGDDEVLRLLAPLDDPAARAAITAERAFLARIGGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 C+VP+G+ A L E+ L ++GA DG +++RG R G+ D +G +LAEELL+ G + Sbjct: 241 CRVPVGALALLEGDELLLYGMIGALDG-RMVRGMRSGSASDPAGLGSALAEELLDAGGQA 299 Query: 302 ILA 304 +LA Sbjct: 300 LLA 302 >UniRef50_A3ETN3 Porphobilinogen deaminase n=2 Tax=Leptospirillum sp. Group II RepID=A3ETN3_9BACT Length = 314 Score = 380 bits (978), Expect = e-104, Method: Composition-based stats. Identities = 151/315 (47%), Positives = 192/315 (60%), Gaps = 5/315 (1%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 ML L+I +R S LALWQA +V L+ S G++ E+V + T GD+ILD L++VGGKG Sbjct: 1 MLPTPLKIGSRGSELALWQARHVAS-LIESVSGVLPEIVVIKTTGDIILDRQLSEVGGKG 59 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E ALL D+AVHSMKDVP P GL L REDPRD F+S +Y + +LP Sbjct: 60 LFVKEIEEALLRKEIDLAVHSMKDVPAFLPPGLTLAATLTREDPRDVFLSPHYPDIKSLP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 + VGTSSLRR Q+ E R DL LRGNVGTR+ K++ G DAIILA AGL RLG Sbjct: 120 QKARVGTSSLRRLAQIREIRNDLEFIPLRGNVGTRIRKMEEGVVDAIILAGAGLLRLGHA 179 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 +R+R + P + LPA+GQGA+G+E R DD T L+ +L+ T L V AER + L G Sbjct: 180 NRVREWISPRVLLPAIGQGALGLEIRTDDETTGTLVRSLSDESTHLSVAAERGVLQSLNG 239 Query: 241 GCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERR---GAPQDAEQMGISLAEELLN 296 GCQVPI +YA + L V G++ I DA QMGI L LL+ Sbjct: 240 GCQVPIAAYAVWEKNRTLSLEGRVLDISGTRRIHARETRDIVTIDDAYQMGIDLGNRLLS 299 Query: 297 NGAREILAEVYNGDA 311 +GA EIL + + Sbjct: 300 DGAEEILNSILKKSS 314 >UniRef50_Q1J288 Porphobilinogen deaminase n=5 Tax=Deinococci RepID=HEM3_DEIGD Length = 309 Score = 380 bits (976), Expect = e-104, Method: Composition-based stats. Identities = 130/304 (42%), Positives = 181/304 (59%), Gaps = 3/304 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILD--TPLAKVGGKGL 61 + + TR S LAL Q +V +L P + + T+GD LA+ G KG Sbjct: 2 RTVTVGTRGSALALAQTRWVVARLKEEWPDTDFRIQTISTKGDRDRAALQSLAQKGDKGF 61 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALP 120 +VKE+E ALL R DIAVHS+KD+P E P+GL + +I +R D RD + + L+ LP Sbjct: 62 WVKEIEDALLAGRIDIAVHSLKDLPTEQPEGLEIASIPKRVDARDVLIGKDGMKRLEDLP 121 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 +G+ VGTSS+RR+ L RPDL I LRGN+ TRL+ L +YDAI+LA AGL R + Sbjct: 122 SGARVGTSSVRRKAFLRAYRPDLQILDLRGNIDTRLAALGTPDYDAIVLAAAGLIRTEMR 181 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 RI + P++ LPA GQGA+ +E R DD + E++ A++ H T RVTAER L Sbjct: 182 HRIDEFIDPDLLLPAPGQGALALETRADDDLSIEVVYAIHDHATDDRVTAEREFLAGLGA 241 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GC P+G++A L DG + L VGA DGSQ+IR G P + +G LA ++L GA+ Sbjct: 242 GCMAPVGAHATLKDGVLTLEGWVGALDGSQVIRATTSGDPAECADLGAELAADMLGQGAQ 301 Query: 301 EILA 304 +++ Sbjct: 302 QLIE 305 >UniRef50_A7GYU4 Porphobilinogen deaminase n=34 Tax=Campylobacterales RepID=HEM3_CAMC5 Length = 311 Score = 379 bits (975), Expect = e-104, Method: Composition-based stats. Identities = 160/304 (52%), Positives = 200/304 (65%), Gaps = 3/304 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +L+IATR+S LALWQ+ ++K +LMA H GL VELV M T+GDVILDTPLAK+GGKGLF Sbjct: 2 KILKIATRKSALALWQSEHIKARLMAQHAGLQVELVGMKTKGDVILDTPLAKIGGKGLFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE ++L + IAVHS+KDVPV F GL L IC RED RDA +S Y D LP + Sbjct: 62 KELEDSMLSGQTHIAVHSLKDVPVAFLDGLVLAAICSREDVRDAMISQRYVKFDDLPQSA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGT+SLRR+ QL RPDL I SLRGNV TRL KL GE+DAIILA+AG+ RL L + Sbjct: 122 KVGTTSLRRKMQLLRMRPDLNIISLRGNVQTRLRKLKEGEFDAIILAMAGINRLNLADEV 181 Query: 184 RAALPPEI--SLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 P +I PA+GQGA+G+E +DD++ E + LN + + ER T LEGG Sbjct: 182 AHIYPFDIAQMTPAMGQGALGVEA-VDDAQILEKIKFLNDERSVIETRVERDFVTLLEGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 CQVPIG A L EI + A+VG PDGS++I + E +G LA E + GA+E Sbjct: 241 CQVPIGINARLASEEIEINAIVGLPDGSEVITENLTAKKSEFESVGKELAREFIARGAKE 300 Query: 302 ILAE 305 +L Sbjct: 301 LLKR 304 >UniRef50_A6WXJ2 Porphobilinogen deaminase n=56 Tax=cellular organisms RepID=HEM3_OCHA4 Length = 314 Score = 378 bits (971), Expect = e-103, Method: Composition-based stats. Identities = 132/306 (43%), Positives = 174/306 (56%), Gaps = 2/306 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGG 58 + + L+I TR S LAL QA+ + +LM +H P +E++PM T GD I D L+++GG Sbjct: 6 LKNGTLKIGTRGSKLALAQAYETRRRLMEAHGLPEEAIEIIPMSTAGDRIQDRALSEIGG 65 Query: 59 KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118 KGLF +E+E AL + R D+AVHS KD+P P GL L EREDPRDAF+ L Sbjct: 66 KGLFTEEIEQALTDGRIDLAVHSTKDMPTVLPDGLHLSVFLEREDPRDAFIGRTASRLLD 125 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 LP G+ VG+SSLRRQ + RPD+ + RGNV TRL KL+ GE D LA AGL+RLG Sbjct: 126 LPQGATVGSSSLRRQALIRRLRPDIQVVIFRGNVDTRLRKLEAGEVDGTFLACAGLRRLG 185 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 L I PE PA GQGA+GIE R+ D+R LLA L H ET + + ERA L Sbjct: 186 LGDVITDLADPESFPPAPGQGAIGIETRIGDTRIDTLLAPLAHRETGIALACERAFLAAL 245 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 +G C+ PI A + + ++ PDGS+ + G +A +G AE L Sbjct: 246 DGSCRTPIAGLATVNGDTVSFHGMILKPDGSEAHEIKTEGPASNAAAIGTEAAEHLRAKA 305 Query: 299 AREILA 304 + Sbjct: 306 GPQFFE 311 >UniRef50_B2S842 Porphobilinogen deaminase n=38 Tax=Rhizobiales RepID=HEM3_BRUA1 Length = 314 Score = 375 bits (965), Expect = e-103, Method: Composition-based stats. Identities = 134/299 (44%), Positives = 170/299 (56%), Gaps = 2/299 (0%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKG 60 + L+I TR S LAL QA+ + L +H P +E++PM T GD I D PL++VGGKG Sbjct: 8 NGTLKIGTRGSKLALAQAYLTRRLLQEAHGLPEDAIEILPMSTAGDRIQDRPLSEVGGKG 67 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF +E+E AL + R DIAVHS KD+P P+GL L EREDPRDAF+ + LP Sbjct: 68 LFTEEIEQALKDGRIDIAVHSTKDMPTALPEGLHLSVFLEREDPRDAFIGRSARRFMDLP 127 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VG+SSLRRQ + RPD+ + RGNV TRL KLD GE D LA AGL+RLGL Sbjct: 128 QGATVGSSSLRRQALIRRLRPDIEVVMYRGNVDTRLRKLDAGEVDGTFLACAGLRRLGLA 187 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 I L P + PA GQGA+GIE R+ D R LLA L H ET + + ERA L+G Sbjct: 188 DVITDVLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERAFLGALDG 247 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 C+ PI A + + R ++ PDG Q G DA +G A + Sbjct: 248 SCRTPIAGLATVEGDRLSFRGMILTPDGRQAHEVTAEGVVSDAAALGTDAANRVRAMAG 306 >UniRef50_Q180R9 Porphobilinogen deaminase n=11 Tax=Bacteria RepID=HEM3_CLOD6 Length = 301 Score = 375 bits (964), Expect = e-102, Method: Composition-based stats. Identities = 111/293 (37%), Positives = 173/293 (59%), Gaps = 1/293 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 + + TR S LAL Q +V ++L +P + E+ + T+GD+I + L K+G KGLFVKE Sbjct: 3 IVVGTRGSNLALIQTEWVINELKKKYPEISFEIKIIKTKGDLIQNVSLDKIGDKGLFVKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALPAGSI 124 +E LL+ + DIAVHSMKD+P GL +REDPRD + Y +LD LP G++ Sbjct: 63 IEQQLLDGKIDIAVHSMKDMPSYLANGLKFAHTPKREDPRDVLILREGYKNLDDLPHGAV 122 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GT S RR+ QL ++RPDL I +RGNV TR+ K+ + I+LA +G+ R L+ +I Sbjct: 123 IGTGSKRRKFQLLKQRPDLNIVQVRGNVETRIRKIKDENMHGIVLAASGIIRANLQDKIS 182 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 + LP ++ +PA QGA+ IE R +DS ++ +L T +++ AER + G C + Sbjct: 183 SYLPVDVVIPAPAQGALAIEIRSNDSAIEGIVNSLKDENTEIQILAERGFLDGVNGSCHI 242 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 P+ +Y E+I +I L L G +G +++ G ++G+ LA+ +L Sbjct: 243 PMAAYCEIIQDKIHLTGLYGDSEGKKVVIKSIDGDISSPRELGLKLAKLVLKE 295 >UniRef50_A6Q7Y4 Porphobilinogen deaminase n=7 Tax=Epsilonproteobacteria RepID=HEM3_SULNB Length = 323 Score = 375 bits (964), Expect = e-102, Method: Composition-based stats. Identities = 137/319 (42%), Positives = 191/319 (59%), Gaps = 10/319 (3%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L IATR S LALWQA+++K+++ + P + VEL + ++GD ILD PLA VGGKG F Sbjct: 2 EKLVIATRASNLALWQAYHIKERIETAFPEVRVELNEITSKGDKILDKPLALVGGKGHFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE ++ A +AVHS+KDVP P+GL L I ER+D D F+S+ Y SL LP G+ Sbjct: 62 KELEDEMIAGNAHLAVHSLKDVPTYIPEGLELCAITERQDQSDVFLSHTYKSLSELPEGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +VGT+SLRR+ QL E+RPDL ++ LRGNV TRL KL G+YDAIILA GL RL L I Sbjct: 122 VVGTTSLRRRMQLLEKRPDLKVKDLRGNVNTRLRKLKEGQYDAIILAYIGLYRLDLLKDI 181 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + +P +GQ A+GIE ++ R RE+ LNH T + ER + + GC Sbjct: 182 PYVEKLDFFIPPMGQAALGIEIVANNDRIREIAMTLNHEPTFICTKVERDFISVIGAGCS 241 Query: 244 VPIGSYAELIDGE------IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 P+ A + E I +RA++G PDG+ I+ +A+ +G LA+ ++ Sbjct: 242 APVAVNATMDKKEDDKVPTISVRAMIGYPDGTHILHKSLTVPLNEADILGDELAQAMIEE 301 Query: 298 GAREILAE----VYNGDAP 312 GA +IL + + + P Sbjct: 302 GALDILEQAEIIAFKDEMP 320 >UniRef50_B6FXV9 Putative uncharacterized protein n=1 Tax=Clostridium hiranonis DSM 13275 RepID=B6FXV9_9CLOT Length = 299 Score = 373 bits (958), Expect = e-102, Method: Composition-based stats. Identities = 113/297 (38%), Positives = 176/297 (59%), Gaps = 1/297 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +R+ TR S LAL Q ++ D+L P + E+ + T+GD IL L K+G KGLFVKE Sbjct: 3 IRVGTRGSNLALIQTNWAIDRLKEKFPEVEFEVKIIKTKGDKILHLSLDKIGDKGLFVKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALPAGSI 124 +E LLE D+AVHSMKD+P E +GL + +REDPRD + +S D LP G+ Sbjct: 63 IESQLLEGEIDLAVHSMKDMPAEVVEGLKFAAVPKREDPRDVIILREGLNSFDELPIGAT 122 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GT S RR+ QL +RPDL I +RGN+ TR+SK+++ D I+LA +G+ R LE +I Sbjct: 123 IGTGSKRRKYQLLRKRPDLNIVPIRGNIETRISKIESENLDGIVLAASGVIRADLEEKIT 182 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 LP ++ +PA QGA+ +E R +D +++ A+ + ++ AER+ ++G C + Sbjct: 183 EFLPVDLMIPAPAQGALALEIRENDEELEKMIDAIKDEISQIQTDAERSYLAGIDGSCHI 242 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 P+G+Y E+ ++ L + G DG +I G + +++G +LA+ +L E Sbjct: 243 PMGAYCEVDGEKLTLTGIFGDEDGEKITVASLEGDRDNPKELGSNLAKLVLKKHREE 299 >UniRef50_D2R3S6 Porphobilinogen deaminase n=2 Tax=Planctomycetaceae RepID=D2R3S6_9PLAN Length = 311 Score = 373 bits (958), Expect = e-102, Method: Composition-based stats. Identities = 144/299 (48%), Positives = 192/299 (64%), Gaps = 2/299 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LR+ TR SPLA WQA +V+D+L+A+ G+ VE++ + T GD PL ++GG+GLF KE Sbjct: 7 LRLGTRASPLARWQADWVRDQLIAA--GIDVEMILITTEGDQQTSQPLGQIGGQGLFTKE 64 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 ++ LL D+AVHS+KD+P GL L + ERED D + SL LP+G+ + Sbjct: 65 IQRRLLAGDIDLAVHSLKDLPTLPIDGLSLAAVPEREDTADILIGPAGTSLATLPSGAKI 124 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT SLRR+ QL R DL I +RGNV TRL KLD G+Y AIILA AGLKRL L+ R+ Sbjct: 125 GTGSLRRKAQLLHARADLEILDIRGNVDTRLRKLDEGQYHAIILAAAGLKRLKLDDRMTE 184 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L + LPAVGQGA+GIE R DD TR+LLA L+H T V AER++ L GC P Sbjct: 185 RLEAPLMLPAVGQGALGIESRSDDPTTRKLLAPLSHAPTLQAVIAERSLLAALRAGCLAP 244 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 +G++A+++DG++ L A+V + DG + AP DA Q+G +AE L GA E+LA Sbjct: 245 VGAHAQVVDGQLTLAAVVLSIDGQSRLFASLTSAPADAAQLGEEVAELLRQQGATELLA 303 >UniRef50_Q43316 Porphobilinogen deaminase, chloroplastic n=61 Tax=cellular organisms RepID=HEM3_ARATH Length = 382 Score = 372 bits (955), Expect = e-101, Method: Composition-based stats. Identities = 137/303 (45%), Positives = 185/303 (61%), Gaps = 8/303 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGL----VVELVPMVTRGDVILDTPLAKVGGKG 60 ++RI TR SPLAL QA+ ++KL HP L + + + T GD IL PLA +GGKG Sbjct: 74 IIRIGTRGSPLALAQAYETREKLKKKHPELVEDGAIHIEIIKTTGDKILSQPLADIGGKG 133 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF KE++ AL+ DIAVHSMKDVP P+ L RED RDAF+ +L LP Sbjct: 134 LFTKEIDEALINGHIDIAVHSMKDVPTYLPEKTILPCNLPREDVRDAFICLTAATLAELP 193 Query: 121 AGSIVGTSSLRRQCQLAERRPDLII-RSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 AGS+VGT+SLRR+ Q+ + P L + + RGNV TRLSKL G+ A +LA+AGLKRL + Sbjct: 194 AGSVVGTASLRRKSQILHKYPALHVEENFRGNVQTRLSKLQGGKVQATLLALAGLKRLSM 253 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 + + L + LPAV QGA+GI CR DD + LA+LNH ET L ++ ERA L+ Sbjct: 254 TENVASILSLDEMLPAVAQGAIGIACRTDDDKMATYLASLNHEETRLAISCERAFLETLD 313 Query: 240 GGCQVPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGA--PQDAEQMGISLAEELLN 296 G C+ PI YA + +G R LV +PDG++++ R+G +D +MG +ELL+ Sbjct: 314 GSCRTPIAGYASKDEEGNCIFRGLVASPDGTKVLETSRKGPYVYEDMVKMGKDAGQELLS 373 Query: 297 NGA 299 Sbjct: 374 RAG 376 >UniRef50_D0LUE1 Porphobilinogen deaminase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LUE1_HALO1 Length = 320 Score = 371 bits (953), Expect = e-101, Method: Composition-based stats. Identities = 157/315 (49%), Positives = 197/315 (62%), Gaps = 11/315 (3%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M + + I+TR S LALWQAH+V+D++ P VELV + T+GD ILD PL+K+GGK Sbjct: 1 MSERTIHISTRGSQLALWQAHHVRDEIRRVRPAWQVELVIIKTQGDKILDVPLSKIGGKA 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E ALL+ RAD+AVHSMKDVP E GL + REDP DA + + LD L Sbjct: 61 LFVKEIEQALLDGRADVAVHSMKDVPAELAPGLFMAATSRREDPYDALCTRDGRGLDELA 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GTSSLRRQCQ+ RRPDL I LRGNV TRL KLD+G +DA+ILA AGLKRLG Sbjct: 121 EGATLGTSSLRRQCQILARRPDLRIEMLRGNVPTRLGKLDDGSFDAVILAAAGLKRLGHG 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDD-----SRTRELLAALNHHETALRVTAERAMN 235 RI L + +PAVGQG +GIE R D L AL+ RV AERAM Sbjct: 181 ERISQRLDGGVCVPAVGQGVLGIETRQGDAPADRELVEALREALHDPAEERRVVAERAMM 240 Query: 236 TRLEGGCQVPIGSYAELID------GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGIS 289 L G CQ P+ ++A G + + L G PDGS+I+R + G +DA+ +G S Sbjct: 241 AALGGSCQTPLAAHASYRGDSDPVAGTLVIEGLCGRPDGSEILRAQVEGRAEDAQALGSS 300 Query: 290 LAEELLNNGAREILA 304 LAEEL GA+ I+ Sbjct: 301 LAEELRGQGAQAIID 315 >UniRef50_A5VM67 Porphobilinogen deaminase n=9 Tax=Lactobacillus RepID=HEM3_LACRD Length = 305 Score = 371 bits (953), Expect = e-101, Method: Composition-based stats. Identities = 118/298 (39%), Positives = 167/298 (56%), Gaps = 4/298 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + N + + +R+S LA+ Q V L P + E+ ++T GD LAK+GGKG+ Sbjct: 1 MTNKVIVGSRKSKLAMAQTELVIASLEKIFPDIKFEIKNVITEGDRNRHVSLAKIGGKGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALP 120 FVKE+E L + D AVHS+KDV P+ L L +R P D VS SL+ LP Sbjct: 61 FVKEIEDELKDGTIDFAVHSLKDVMPILPEELVLGAFPKRVSPYDCLVSRKNLSSLNDLP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GT+SLRRQ QL RPDL I +RGN+ TRL K+D D IILA AGL RL ++ Sbjct: 121 KGARIGTNSLRRQGQLLSIRPDLKIIPIRGNIDTRLRKIDTEALDGIILAEAGLTRLNID 180 Query: 181 SRIRAALPPE-ISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 L + +PAVGQG + IECR +D+R R++L +N E+A V ER L Sbjct: 181 LSSYHVLDLQNYIMPAVGQGCLAIECRKNDTRIRKMLDQINDEESAYCVQVEREFMRELG 240 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 G C PIG +A +G+I L+ +P+G +I+ + P + +G +A++LL Sbjct: 241 GSCNFPIGGHAYAKNGQILFDGLIASPNGEHVIKETKI--PANNSGVGKKVADQLLAK 296 >UniRef50_O94048 Porphobilinogen deaminase n=53 Tax=Saccharomyceta RepID=HEM3_CANAL Length = 340 Score = 368 bits (946), Expect = e-100, Method: Composition-based stats. Identities = 131/319 (41%), Positives = 186/319 (58%), Gaps = 17/319 (5%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 N ++I R+S LA+ Q+ VK + + P L ++ + T GD + PL GGK L+ Sbjct: 11 SNHVQIGGRKSKLAVVQSEIVKKVIEDTFPNLSCSILALSTLGDKVQTQPLYTFGGKSLW 70 Query: 63 VKELEVALLEN-----RADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YD 114 KELE+ LL++ + D+ VHS+KD+P P+ L I +REDPRDA V Y Sbjct: 71 TKELEILLLDSVDEFPKLDLIVHSLKDMPTNLPEEFELGCIFQREDPRDAIVMKQGSSYK 130 Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVA 172 SL LPAG+IVGTSS+RR QL + P L S+RGN+ TRL+KLD N EY +ILA A Sbjct: 131 SLKDLPAGAIVGTSSIRRSSQLIKNYPHLRFESVRGNIQTRLNKLDQPNNEYCCLILASA 190 Query: 173 GLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232 GL RLGL RI + + AVGQGA+GIE R D + +L + + AER Sbjct: 191 GLIRLGLGHRITSY--LDDMYYAVGQGALGIEIRKGDDNIKSILKKIEDPIATICCLAER 248 Query: 233 AMNTRLEGGCQVPIGSYAELIDG--EIWLRALVGAPDGSQIIRGE---RRGAPQDAEQMG 287 ++ LEGGC VP+G +++ + E+ L+ ++ +PDG+ I E R +D EQ+G Sbjct: 249 SLMRYLEGGCSVPLGVHSDYNESKQELTLKGIIVSPDGTVSIEDEVIKRITCDEDCEQVG 308 Query: 288 ISLAEELLNNGAREILAEV 306 I L ++L GA+EIL ++ Sbjct: 309 IELGDKLKAKGAKEILDKI 327 >UniRef50_Q3YSA8 Porphobilinogen deaminase n=17 Tax=Rickettsiales RepID=HEM3_EHRCJ Length = 298 Score = 368 bits (945), Expect = e-100, Method: Composition-based stats. Identities = 112/293 (38%), Positives = 175/293 (59%), Gaps = 3/293 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LAL Q V + L P + +++V + T GD+ P+ +GGKGLF+KE Sbjct: 3 IRIGTRGSVLALAQTLEVTNLLNRYFPEINIQVVKIKTSGDINNKVPINTIGGKGLFIKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E ALL + D+AVHS+KD+P + GL + + +R P D FVS+ Y S+ +LP + V Sbjct: 63 IEEALLIGKVDLAVHSVKDIPAFYCDGLIIPCVLKRSSPYDVFVSSKYQSIKSLPINATV 122 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR+ QL RPDL + +RGN+ TR+ K D GE+D I+LA AGL R+ + I+ Sbjct: 123 GTSSIRRKVQLNYLRPDLQVIPVRGNIDTRILKSDIGEFDGIVLAEAGLIRINKCNVIKE 182 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L +I L AVGQGA+ ++CR DD + LN H++ + V AER+ + G C P Sbjct: 183 VLDSKIMLSAVGQGAICVQCRADDYNIINKIKVLNCHKSYVCVIAERSFLKTINGSCDTP 242 Query: 246 IGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 + + A+ +D I++ ++ +++ + +AE+ GI + ++L+N Sbjct: 243 LAALAQYVDSDTIYMSCMLSNE--KEMVFSDCYFKECNAEESGIDMGKKLINE 293 >UniRef50_C8WXM9 Porphobilinogen deaminase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WXM9_ALIAD Length = 305 Score = 367 bits (943), Expect = e-100, Method: Composition-based stats. Identities = 151/301 (50%), Positives = 196/301 (65%), Gaps = 2/301 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 LR+ATR+S LAL Q ++V D L G+ ELVP+ TRGD I+D L++VGGKGLFV Sbjct: 2 RTLRVATRRSALALTQTNHVVDLLKQVAHGVEFELVPIRTRGDEIVDRALSEVGGKGLFV 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 ++E AL +AD+AVHS+KDVP E GL + + REDPRDA +S L LP G+ Sbjct: 62 ADIEDALATGQADLAVHSLKDVPFELRDGLTIGAVPPREDPRDALISRTGQGLFDLPPGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGTSSLRRQ L RPDL + +LRGNV TRL +L+ G++DAI+LA +GL RLGL RI Sbjct: 122 RVGTSSLRRQAALRRLRPDLCVETLRGNVDTRLRRLEEGQFDAIVLAASGLHRLGLAERI 181 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 LP + +PAVGQGA+ IECR +D LAA+ + V AERA +RLEG CQ Sbjct: 182 TEYLPVDRFVPAVGQGALAIECRAEDDEVMRHLAAIADPDATRAVEAERAFLSRLEGSCQ 241 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 VPIG+YAE + E+ L A V P G ++ ER G +A +G+++AEE+L GA + L Sbjct: 242 VPIGAYAEPVGHELRLIAFVADPSGIHHLQLERTG--DEARALGVAMAEEMLRQGAEDWL 299 Query: 304 A 304 Sbjct: 300 K 300 >UniRef50_A8LIJ6 Porphobilinogen deaminase n=11 Tax=Alphaproteobacteria RepID=A8LIJ6_DINSH Length = 347 Score = 365 bits (938), Expect = 1e-99, Method: Composition-based stats. Identities = 144/297 (48%), Positives = 190/297 (63%), Gaps = 2/297 (0%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKG 60 D+ L+I TR S LAL QAH + +L A+ P E+V + T GD I D L+++GGKG Sbjct: 38 DSPLKIGTRGSLLALAQAHETRARLSAAFDLPEEAFEIVVIKTTGDRIQDRSLSEIGGKG 97 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF +E+E A+L+ DIAVHSMKD+PV+ P GL L T RED RDAFV+ + +L LP Sbjct: 98 LFTREIEDAMLDGSIDIAVHSMKDMPVDTPAGLALDTYLPREDVRDAFVTLDGGTLADLP 157 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G++VG+SSLRR+ QLA RRPDL + RGNV TR+ KL +G A LA+AGL RLG++ Sbjct: 158 EGAVVGSSSLRRRAQLAHRRPDLQLVEFRGNVQTRMKKLGDGVAHATFLAMAGLNRLGMD 217 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R+A+ PE LPAV QG +GIE R DD R E+LAA++ + R+ ERA + L+G Sbjct: 218 EVPRSAIAPEDMLPAVAQGCIGIERRADDPRAAEMLAAIHDGPSGHRLACERAYLSALDG 277 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 CQ PI AEL G I LRA + PDGS+++ +DA +MG +AE L Sbjct: 278 SCQTPIAGLAELDGGSIHLRAEILRPDGSEVLSDSETAPVEDAAKMGREVAERLRAR 334 >UniRef50_P28789 Porphobilinogen deaminase n=18 Tax=Saccharomycetales RepID=HEM3_YEAST Length = 327 Score = 364 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 123/322 (38%), Positives = 177/322 (54%), Gaps = 15/322 (4%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M L I R+S LA+ Q+++V + +P ++ + T GD I PL GGK Sbjct: 1 MGPETLHIGGRKSKLAVIQSNHVLKLIEEKYPDYDCKVFTLQTLGDQIQFKPLYSFGGKA 60 Query: 61 LFVKELEVALL----ENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NY 113 L+ KELE L + D+ VHS+KD+P P+G L I +R DP D V Y Sbjct: 61 LWTKELEDHLYHDDPSKKLDLIVHSLKDMPTLLPEGFELGGITKRVDPTDCLVMPFYSAY 120 Query: 114 DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAV 171 SLD LP G IVGTSS+RR QL + P L S+RGN+ TRL KLD+ + Y IILA Sbjct: 121 KSLDDLPDGGIVGTSSVRRSAQLKRKYPHLKFESVRGNIQTRLQKLDDPKSPYQCIILAS 180 Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231 AGL R+GLE+RI + AVGQGA+GIE R D++ ++L + + +E Sbjct: 181 AGLMRMGLENRITQRFHSDTMYHAVGQGALGIEIRKGDTKMMKILDEICDLNATICCLSE 240 Query: 232 RAMNTRLEGGCQVPIGSYAELIDG--EIWLRALVGAPDGSQIIRGE----RRGAPQDAEQ 285 RA+ LEGGC VPIG ++ + ++ L+A+V +G++ + E +D+ Sbjct: 241 RALMRTLEGGCSVPIGVESKYNEETKKLLLKAIVVDVEGTEAVEDEIEMLIENVKEDSMA 300 Query: 286 MGISLAEELLNNGAREILAEVY 307 G LAE ++ +GA++IL E+ Sbjct: 301 CGKILAERMIADGAKKILDEIN 322 >UniRef50_A9A1A1 Probable porphobilinogen deaminase n=3 Tax=Thaumarchaeota RepID=HEM3_NITMS Length = 311 Score = 364 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 107/296 (36%), Positives = 171/296 (57%), Gaps = 2/296 (0%) Query: 7 RIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66 + R S L++ Q + V +L +HP E+ + T+GD PL + KG+F KE+ Sbjct: 4 IVGARGSQLSVAQTNLVIAELKKAHPDTEYEIKTITTKGDTD-SRPLFTIDQKGIFEKEI 62 Query: 67 EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126 + A+ + D AVHS+KDVP E L L I +RE D F+S + +LD++ GS++G Sbjct: 63 DRAVAQKEVDFAVHSLKDVPSELDDNLVLACIPKRETVNDVFISPDGSTLDSIKPGSVIG 122 Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAA 186 TSSLRR Q++ +RPD+ ++ +RGN+ TR+ K YDAI+LA AG+ RLG++ + Sbjct: 123 TSSLRRAVQVSRKRPDVTVKPIRGNIETRIKKASGENYDAIVLAKAGISRLGVDVKYTE- 181 Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246 L + P+ GQGA+ I R DDS+T E+L + ++ L + AERA++ ++ GC+ P+ Sbjct: 182 LSTDDFSPSPGQGAIAIVARADDSKTIEMLKKIEDPDSRLEIEAERALSDFVDSGCRFPV 241 Query: 247 GSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 G+YA+ E+ L + DG Q + + G + + +G S EEL G ++ Sbjct: 242 GAYAKSNGSEMTLTVTAFSVDGKQFLHVSKTGDKNNPKSLGQSAGEELREKGVNDL 297 >UniRef50_C1CYD9 Porphobilinogen deaminase n=3 Tax=Deinococci RepID=HEM3_DEIDV Length = 311 Score = 364 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 126/306 (41%), Positives = 178/306 (58%), Gaps = 5/306 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDT--PLAKVGGKGL 61 + + TR S LAL Q +V +L P + + T+GD ++ +A+ G KG Sbjct: 2 RTVTVGTRGSTLALAQTRWVVARLKEEWPDTDFRIQTISTKGDRNRESLEAMAQKGDKGF 61 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALP 120 +VKE+E ALL+ R DIAVHS+KD+P E P+GL + +I +R D RD + L LP Sbjct: 62 WVKEIEDALLQKRIDIAVHSLKDLPTEQPEGLEVASIPKRVDARDVLIGKEGMKRLADLP 121 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGTSS+RR+ L RPDL + LRGN+ TRL+ L EYDAIILA AGL R + Sbjct: 122 QGARVGTSSVRRKAFLRAYRPDLQVIDLRGNIDTRLAALAGDEYDAIILAAAGLIRTEMR 181 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRL--DDSRTRELLAALNHHETALRVTAERAMNTRL 238 RI + P+I LPA GQGA+ +E R ++ T E+ A++ H T R+TAER L Sbjct: 182 HRIDEFVEPDILLPAPGQGALALETRSGPENDLTIEVAYAIHDHGTDDRITAEREFLAGL 241 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GC P+G++A + G + L VGA DGS++IR G P + +G LA ++L G Sbjct: 242 GAGCMAPVGAHASIKGGVLTLEGWVGALDGSKVIRATSIGDPAECADIGAELAGDMLGQG 301 Query: 299 AREILA 304 A+ ++ Sbjct: 302 AQALID 307 >UniRef50_D1CBT4 Porphobilinogen deaminase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CBT4_THET1 Length = 300 Score = 363 bits (933), Expect = 4e-99, Method: Composition-based stats. Identities = 112/297 (37%), Positives = 171/297 (57%), Gaps = 2/297 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 V+++ TR S LALWQ +V ++L + +PG E V + D D P++ +G G+F Sbjct: 2 KVIKVGTRGSKLALWQTQWVINRLRSLYPGFQFEPVVIKVTSDRSPDAPISAIGQVGVFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 K++E ALL +AVHS+KD+P G + EREDPRD + + L S Sbjct: 62 KDIEQALLAGDIHLAVHSLKDLPTLSTPGTVIAAFTEREDPRDCILWPKGQPMPDL-NNS 120 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGTSS+RR + P+ + +LRGNV TR+ K+ G YD +++A A +KR+ L Sbjct: 121 RVGTSSVRRSALVRSYWPNANVVNLRGNVDTRVRKMLEGNYDVVLMAYAAVKRMDLPVEF 180 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + LP + +P+ GQG + ++ R DD + +L A+N + + AER++ L GGC Sbjct: 181 K-PLPLDSWVPSAGQGIIAVQAREDDQQIIGMLNAINFFPSKVAYLAERSLMRALGGGCS 239 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 +P+G+YAEL DGE+ L +V APDGSQ++ R P A+ +G +A E+L+ G R Sbjct: 240 MPVGAYAELHDGELSLIGMVAAPDGSQVVITRRVDTPDQADHLGERVAREMLDLGIR 296 >UniRef50_Q8RFP5 Porphobilinogen deaminase n=16 Tax=Fusobacteriaceae RepID=HEM3_FUSNN Length = 298 Score = 362 bits (929), Expect = 1e-98, Method: Composition-based stats. Identities = 119/298 (39%), Positives = 166/298 (55%), Gaps = 5/298 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPL--AKVGGK 59 + + I +R S LAL QA+ VKD+L ++P L E+ +VT GD L + + + K Sbjct: 1 MKKNIIIGSRGSILALAQANLVKDRLQGNYPNLSFEIKEIVTSGDKDLKSNWENSDISLK 60 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 F KE+E LL+ DIAVHSMKD+P + L I +REDPRD VS N L L Sbjct: 61 SFFTKEIEQELLDGEIDIAVHSMKDMPAVSAKSLICGAIPDREDPRDVLVSKNGL-LVTL 119 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P G+ VGTSSLRR L RPD I+ LRGN+ TRL KL+ +YDAI+LA AGLKR GL Sbjct: 120 PQGAKVGTSSLRRAMNLKTVRPDFEIKHLRGNIHTRLKKLETEDYDAIVLAAAGLKRTGL 179 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 +I L E+ PA QG + I+CR +D +E+L ++++ A V ER + + Sbjct: 180 ADKITEYLNGEVFPPAPAQGVLYIQCRENDEEIKEILKSIHNEAIAKIVEIEREFSKIFD 239 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 GGC P+G Y+++ +I A+ D + IR +++ AEE+ N Sbjct: 240 GGCHTPMGCYSQVNGDKIKFTAVY--LDEGKQIRAVVEDDLAKGKEIAYMAAEEIKNK 295 >UniRef50_C3XEZ5 Porphobilinogen deaminase n=3 Tax=Campylobacterales RepID=C3XEZ5_9HELI Length = 328 Score = 361 bits (928), Expect = 1e-98, Method: Composition-based stats. Identities = 147/315 (46%), Positives = 191/315 (60%), Gaps = 12/315 (3%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + L + TR S LALWQA+++K+KL + G V L + T+GD ILD PLAK+GGKGLF Sbjct: 12 EKPLVLGTRGSLLALWQANHIKEKLESL--GFQVVLKTIKTKGDKILDAPLAKIGGKGLF 69 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 KELE LL D AVHS+KDVP+ P L LV+I +RED RD FVS Y + +LP G Sbjct: 70 TKELENELLSGGIDFAVHSLKDVPIAIPPELMLVSITQREDARDCFVSEKYADIASLPQG 129 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 + VGT+SLRR QL R DL +SLRGNV TRL KL GE+DAIILA AGL RL L+ Sbjct: 130 AKVGTTSLRRSMQLKRIRQDLDTQSLRGNVQTRLEKLRKGEFDAIILASAGLNRLDLKDD 189 Query: 183 IRAALPPEI--SLPAVGQGAVGIECRL-------DDSRTRELLAALNHHETALRVTAERA 233 I +I +PA+GQG++GIECR D ++L +L+ ++AL ERA Sbjct: 190 IGFISHLQINQFIPAMGQGSLGIECRDPKYSPDFRDQAIMKVLESLHDSKSALCCNIERA 249 Query: 234 MNTRLEGGCQVPIGSYAELIDG-EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAE 292 L GGCQ PIG +A+++D EI ++ +VG D S+++ R + E + Sbjct: 250 FIQLLGGGCQSPIGIHAQILDSKEIEIQCVVGNLDASKVLTETRVCNKGEVEYALQDMIN 309 Query: 293 ELLNNGAREILAEVY 307 L NG EIL EV Sbjct: 310 TLKKNGVMEILEEVR 324 >UniRef50_Q5HBG1 Porphobilinogen deaminase n=2 Tax=Ehrlichia ruminantium RepID=Q5HBG1_EHRRW Length = 299 Score = 361 bits (927), Expect = 2e-98, Method: Composition-based stats. Identities = 112/298 (37%), Positives = 177/298 (59%), Gaps = 3/298 (1%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M + + TR S LA+ QA VK L P + V++V +VT GD+ L+++GGKG Sbjct: 1 MNSMNVYVGTRGSILAIAQAMEVKKLLYNYFPDINVQIVHIVTSGDINDKISLSEIGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF+KELE ALL D+AVHSMKDVP + L + I +R P D F+S+ Y SL +LP Sbjct: 61 LFLKELEEALLTGTIDLAVHSMKDVPAFYCDSLVIPCILKRSSPYDVFISSKYQSLRSLP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 +++GTSS+RR+ QL + + +RGNV TR+ KL+ G+YD IILA AGL R+ Sbjct: 121 DNAVIGTSSIRRKVQLMRLLSSVQVVPIRGNVDTRILKLEAGQYDGIILAKAGLMRINKT 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 I+ L P++ L AVGQGA+GI+CR +D + +++ LN ++ + V AER+ + G Sbjct: 181 HVIKEVLDPQVMLSAVGQGAIGIQCRANDYKMIDMIKILNCKKSYISVAAERSFMKTVNG 240 Query: 241 GCQVPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 C P+ + A+ ++ +++ ++ + + + + DAE GI++ +L++ Sbjct: 241 SCDTPLAALAKYVNSDTLYMSCMLSNEE--KTVFSDCYFNECDAEISGINMGNDLMDQ 296 >UniRef50_UPI00017922DC PREDICTED: similar to porphobilinogen deaminase n=1 Tax=Acyrthosiphon pisum RepID=UPI00017922DC Length = 377 Score = 360 bits (926), Expect = 3e-98, Method: Composition-based stats. Identities = 130/359 (36%), Positives = 186/359 (51%), Gaps = 59/359 (16%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +R+ +R+S LAL Q +V +L HP + E+V M T GD +LD PL K+G K LF Sbjct: 7 KTIRVGSRKSELALIQTKFVISQLKELHPEIEFEIVSMTTMGDRVLDKPLPKIGEKSLFT 66 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLDALP 120 K+LEVALL D VHS+KD+P G + I +R+DPRDA V + LD+LP Sbjct: 67 KDLEVALLSGTVDFIVHSLKDLPTVMEIGTTIGAILKRDDPRDALVLRDDCKEYQLDSLP 126 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE---------YDAIILAV 171 + S +GTSSLRR QL + P+L + +RGN+ TRL KLD+ + Y IILA+ Sbjct: 127 SKSFIGTSSLRRTAQLKRKFPNLQVSDVRGNLNTRLKKLDSSQSTGDNTNTNYSGIILAL 186 Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231 AG++R+G E R+ + ++ L AVGQGA+ +ECRL D E+L L+H+ET L+V AE Sbjct: 187 AGIQRMGWEKRVSQIIDSDVMLYAVGQGALAVECRLGDDYILEMLEPLHHYETVLQVVAE 246 Query: 232 RAMNTRLEGGCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQD------- 282 R TRL GGC P+G + + + L V + DG++ ++ D Sbjct: 247 RGFLTRLGGGCSAPVGIRSTVCLTKNAMSLDGAVWSLDGAEELQYSSSAELADKKVIQSH 306 Query: 283 --------------------------------------AEQMGISLAEELLNNGAREIL 303 A ++G LAE L++ GA +I+ Sbjct: 307 IDQYRGEDGEPPKKCPYKQPRQFVGVTPGKISYLDLDTALKLGTELAENLISKGALDIM 365 >UniRef50_B0K2L4 Porphobilinogen deaminase n=7 Tax=Bacteria RepID=B0K2L4_THEPX Length = 299 Score = 360 bits (926), Expect = 3e-98, Method: Composition-based stats. Identities = 110/296 (37%), Positives = 172/296 (58%), Gaps = 3/296 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + V+++ TR S LAL Q V +++ E+V + T+GD ++D P++++GGKG+ Sbjct: 1 MKKVIKVGTRSSELALKQTAMVINEIKKFRQDFEFEIVKITTQGDALIDKPVSEIGGKGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKE+E ALL+ D+AVHSMKD+P E P+GL L+ + +REDP+D FVS + L Sbjct: 61 FVKEIESALLKGEIDMAVHSMKDMPYEIPKGLKLMAVLKREDPKDVFVSGDGTQFMDLKE 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ +GTSSLRRQ QL +PD+ I +RGNV TRL K++ D I+L+ AGL RLGLE+ Sbjct: 121 GAKIGTSSLRRQVQLKALKPDIQIVPIRGNVRTRLKKMEELNLDGIVLSAAGLHRLGLEN 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLEG 240 I PP++ +PA QG + +E D+ +E + +T + ER + Sbjct: 181 IITEYFPPDVVVPAPCQGILAVEIAESFDNIFQEFYPYIVDRKTFFEASVERELLKAFGV 240 Query: 241 GCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 C+ P G+YA+ + E + V +++++ E G ++ ++M L EE Sbjct: 241 NCRQPFGAYAQYRKEEDEEKINIKVAYQKENKLLKSEVTGLIEETDKMIEKLIEEF 296 >UniRef50_Q4HT06 Porphobilinogen deaminase n=1 Tax=Campylobacter upsaliensis RM3195 RepID=Q4HT06_CAMUP Length = 308 Score = 359 bits (922), Expect = 8e-98, Method: Composition-based stats. Identities = 151/304 (49%), Positives = 201/304 (66%), Gaps = 4/304 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L IATR+SPLALWQ+ +V D L +H G+ V L T+GD++LD+PLAK+GGKGLF Sbjct: 2 KKLIIATRKSPLALWQSEFVADILRKTH-GIEVHLEGFSTKGDILLDSPLAKIGGKGLFT 60 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE A+LEN+A +AVHS+KDVP PQGL L + RED DA +S Y L+ALP + Sbjct: 61 KELENAMLENKAHLAVHSLKDVPSFLPQGLVLAALSVREDDTDALLSELYKDLNALPQNA 120 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGT+SLRR+ QL RPDL I +LRGNV +RL +L GE+DAIILA AG+KRLGLES + Sbjct: 121 KVGTTSLRRKMQLLSLRPDLHIINLRGNVNSRLKRLKGGEFDAIILASAGVKRLGLESEV 180 Query: 184 RAAL--PPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + + +PA QG +GI+ D + LL LN ++ + T ER LEGG Sbjct: 181 KFIYRFSKDELVPAATQGILGIQS-PDKNEILTLLQCLNDEKSLIESTVERDFIRTLEGG 239 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 CQVPIG AEL+ +I +R+++G PDGS+I+R +R ++ + G LA E + GA+E Sbjct: 240 CQVPIGINAELMGEQITVRSILGLPDGSEILRDKRIILKKNYQGFGERLALEFIKRGAKE 299 Query: 302 ILAE 305 +L Sbjct: 300 LLKR 303 >UniRef50_B3T8H9 Putative Porphobilinogen deaminase, dipyromethane cofactor binding domain protein n=1 Tax=uncultured marine microorganism HF4000_APKG5H11 RepID=B3T8H9_9ZZZZ Length = 322 Score = 357 bits (918), Expect = 2e-97, Method: Composition-based stats. Identities = 121/300 (40%), Positives = 170/300 (56%), Gaps = 1/300 (0%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +++ +R S LAL Q H V ++L A+ P L E+ + TRGDV + LA +G G+FVK Sbjct: 17 AIKVGSRGSTLALIQDHVVINRLKANSPALEFEVDTVRTRGDVDQTSRLAGMGL-GIFVK 75 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 ELE LL+ + DIAVHS+KD+P + GL L + REDPRD V+ LD LP G+ Sbjct: 76 ELEQELLDGKLDIAVHSLKDMPTQLADGLVLGAVLSREDPRDVLVNRYGCPLDGLPKGAK 135 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSS RR QL + P + + S+RGNV TRL K E D ILA AG+ RLGL+ +I Sbjct: 136 IGTSSPRRAAQLKQYAPQVEVVSIRGNVETRLRKAQGEEADGAILAAAGMIRLGLQDQIA 195 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L +P GQG + +E R DD R ELL+A++ +T TAER RL GGC + Sbjct: 196 EYLSATQFVPPPGQGILAVEARADDFRMLELLSAIDDADTRYEATAERGFLARLGGGCSI 255 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 P+G+YA I + + DG + + +G +D Q+ L+ G +++A Sbjct: 256 PVGAYARCNGDNIVMTIYMSTADGEKKFSAKIQGLKRDPLQLANDAYLALVERGGADLVA 315 >UniRef50_C3WGN0 Porphobilinogen deaminase n=5 Tax=Fusobacterium RepID=C3WGN0_9FUSO Length = 301 Score = 357 bits (916), Expect = 4e-97, Method: Composition-based stats. Identities = 123/311 (39%), Positives = 173/311 (55%), Gaps = 13/311 (4%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPL--AKVGGK 59 + + I +R S LAL QA VK+ L A++P L E+ +VT GD L + + K Sbjct: 1 MKRHVVIGSRGSILALAQASLVKNSLEANYPDLTFEIKEIVTSGDKDLKSNWENSNASLK 60 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 F KE+E LL+ + DIAVHSMKD+P P+GL I +RED RD +S N L L Sbjct: 61 SFFTKEIEQELLDGQIDIAVHSMKDMPAVSPKGLICGAIPDREDARDVLISKNG-FLVTL 119 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P G+ +GTSSLRR L RPD I+ LRGN+ TRL KL+ +YDAIILA AGLKR G+ Sbjct: 120 PQGAKIGTSSLRRVMNLKAIRPDFEIKHLRGNIHTRLKKLETEDYDAIILAAAGLKRTGM 179 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 +I L E PA QG + I+CR +D + +L ++++ + A V ER + + Sbjct: 180 ADKITEYLSGEAFPPAPAQGVLYIQCRENDEEIKGILKSIHNEDIAKIVEIEREFSKIFD 239 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GGC P+G Y+++ + +I A + DG QI R +D G +A + A Sbjct: 240 GGCHTPMGCYSQVDEDKIKFIAA-YSHDGKQI-----RVVIEDDLTKGKEIA----HMAA 289 Query: 300 REILAEVYNGD 310 EI A++ G+ Sbjct: 290 EEIKAKINKGN 300 >UniRef50_C6XGK7 Porphobilinogen deaminase n=1 Tax=Candidatus Liberibacter asiaticus str. psy62 RepID=C6XGK7_LIBAP Length = 307 Score = 356 bits (915), Expect = 5e-97, Method: Composition-based stats. Identities = 113/297 (38%), Positives = 162/297 (54%), Gaps = 2/297 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGG 58 M RI TR SPLAL A + LM H P + ++P+ T+GD I + L ++GG Sbjct: 1 MEKKPFRIGTRCSPLALAHAFETRSSLMDVHKIPPHNIVIIPLSTKGDRITNRTLTEIGG 60 Query: 59 KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118 KGLF +E+E L+ D AVHS KD+P + +GL + RED RD F+S+ SL Sbjct: 61 KGLFTEEIEKKLISGEIDCAVHSAKDMPTKLLKGLQISAYLPREDIRDVFISHTAQSLKD 120 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 L S++GTSSLRR+ L R D+ + RG + TRL+KL+N + AI+LA AG+KRL Sbjct: 121 LALHSVIGTSSLRRKALLLRWRSDISVIDFRGKIETRLNKLNNNKAHAILLAYAGIKRLK 180 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 E I+ L E P+ GQGA+ IE +++ + +EL+ +NH +T V ERA L Sbjct: 181 KEKVIKEILNIEDFPPSPGQGAICIETHVNNPKAQELVKVINHEDTWDSVNCERAFLAEL 240 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295 +G C+ I +A ++ +V A DG R G DA +G A+ + Sbjct: 241 DGSCKSAIAGFAYCKGSTLYFYGIVLASDGKIFHEVSRNGNRCDAINIGRDAAQYIR 297 >UniRef50_UPI0001926E0E PREDICTED: similar to hydroxymethylbilane synthase, partial n=1 Tax=Hydra magnipapillata RepID=UPI0001926E0E Length = 418 Score = 355 bits (913), Expect = 9e-97, Method: Composition-based stats. Identities = 123/342 (35%), Positives = 167/342 (48%), Gaps = 35/342 (10%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + + +R+S LA+ Q + L + + M T GD IL L K+G K LF Sbjct: 28 KTSVVVGSRKSQLAVIQTKSIVAALCQKEKDVECIIETMDTLGDKILHIALPKIGEKSLF 87 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDAL 119 K+LE+AL E R D VHS+KD+P PQG+ + TI +R+DPRD + + N L L Sbjct: 88 TKDLELALSEKRVDFLVHSLKDLPTTLPQGMAISTIYKRDDPRDCIIFHPKHNGKKLADL 147 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-YDAIILAVAGLKRLG 178 P SI+GTSSLRR QL + L +S+RGN+ TRL KL+ YDAI+LA AG+ R+G Sbjct: 148 PENSIIGTSSLRRVAQLKRKYNKLTFQSVRGNLNTRLQKLEEESLYDAIVLAKAGVDRMG 207 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 +I L + L A+GQGA+ +E R DD T +LA L ET L AER L Sbjct: 208 WTEKIGQILSEDECLYAIGQGAITVEVRNDDKYTISILAQLTDMETLLACVAERCFMRTL 267 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ----------------- 281 GGC PI +++ LR +V DGS+ + Q Sbjct: 268 NGGCSTPIACHSQFSGNNYSLRGIVLNADGSRFLDSTVSTTLQVNILTDQNEPPSYTVSK 327 Query: 282 --------------DAEQMGISLAEELLNNGAREILAEVYNG 309 AE+ G LA L GA ++L EV + Sbjct: 328 SGVVINSLYINEFIKAEKCGEELAYCLKKLGADDVLKEVRSK 369 >UniRef50_UPI0000583C22 PREDICTED: hypothetical protein n=1 Tax=Strongylocentrotus purpuratus RepID=UPI0000583C22 Length = 324 Score = 355 bits (912), Expect = 1e-96, Method: Composition-based stats. Identities = 125/315 (39%), Positives = 179/315 (56%), Gaps = 13/315 (4%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 ++R+ +R+S LA+ Q ++V + L HP ++V M T GD I D PLA +G LF Sbjct: 6 EIVRVGSRKSELAMIQTNHVVEMLQKVHPETEFKIVTMETIGDHIQDKPLASIGESNLFT 65 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALP 120 KELE AL + D+ VHS+KD+P P + + ICEREDP DA V + S++ + Sbjct: 66 KELEKALALDEVDMLVHSLKDMPSRLPSNMAIGAICEREDPHDALVLHKKLTGISIETMK 125 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-YDAIILAVAGLKRLGL 179 GS++GTSS+RR QL + P L+ + +RGN+ TRL KLD G+ YD ++LAVAG+ R+G Sbjct: 126 EGSVLGTSSVRRVAQLKRKFPHLVFKDVRGNLNTRLRKLDEGQVYDGLVLAVAGMMRMGW 185 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 E RI L P+I +V QGA+GIE + + R ELL LNH T +R AER + LE Sbjct: 186 EHRISQILKPDICKYSVSQGALGIEIKTKNRRMHELLRQLNHVPTLIRCIAERGLLKTLE 245 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGA------PQDAEQMGISLAEE 293 GGC P+ ++EL + L A + + Q+AE +G+S+A+ Sbjct: 246 GGCSAPVAVHSELEENRHSLDAET---NEEMKLFSSVIAPWVSQHAMQEAEALGVSVAKG 302 Query: 294 LLNNGAREILAEVYN 308 L + GA IL Sbjct: 303 LFDKGAGPILEAAKE 317 >UniRef50_Q2S2A6 Porphobilinogen deaminase n=1 Tax=Salinibacter ruber DSM 13855 RepID=Q2S2A6_SALRD Length = 323 Score = 354 bits (910), Expect = 2e-96, Method: Composition-based stats. Identities = 144/308 (46%), Positives = 193/308 (62%), Gaps = 5/308 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + + L + TR S LAL QA+ V+ +L A+ G VEL + TRGD DTP++++G + + Sbjct: 3 ISDPLVLGTRGSELALRQANVVRSRLEAA--GHRVELETITTRGDEATDTPISEIGDEAV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN--YDSLDAL 119 F KEL+ ALL+ D+AVHS+KD+P P GL L I EREDPRDAFV++ L L Sbjct: 61 FTKELDRALLQGGVDLAVHSLKDIPSTVPSGLALAAIGEREDPRDAFVAHPSFDGHLHDL 120 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P G+ V T+SLRR QL R DL + +RGNV TRL KL ++ ++LAVAGL RLGL Sbjct: 121 PEGATVATASLRRTAQLLTWRSDLEVVPVRGNVDTRLEKLGESDWTGMVLAVAGLVRLGL 180 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAA-LNHHETALRVTAERAMNTRL 238 IR + P + +PAVGQGA+GI CR D R+LL L+H + AERA ++ Sbjct: 181 SLHIRDRIDPSLIVPAVGQGALGIACREDQDALRDLLRETLHHAPSGHAANAERAFLKKV 240 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GGCQVP+G++A + DG + L A + A DGS+ R ERR AP+D +G LA +LL G Sbjct: 241 GGGCQVPLGAWAHIDDGTLVLDACIAALDGSEHYRDERRCAPEDGAAVGRKLAADLLAMG 300 Query: 299 AREILAEV 306 IL +V Sbjct: 301 GDHILDDV 308 >UniRef50_A6GVP0 Hydroxymethylbilane synthase n=18 Tax=Bacteroidetes RepID=A6GVP0_FLAPJ Length = 308 Score = 353 bits (906), Expect = 6e-96, Method: Composition-based stats. Identities = 111/311 (35%), Positives = 174/311 (55%), Gaps = 8/311 (2%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M ++I TR S LALWQAH+V+ L + G +++ + ++GD+ILD PL ++G G Sbjct: 1 MAKKTIKIGTRDSELALWQAHHVEKML--NDLGHKTKIIAVKSQGDIILDKPLYELGITG 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 +F K L++A++ DIAVHSMKDVP PQG+ + ER + +D V NN +LD L Sbjct: 59 IFTKTLDIAMVNGDIDIAVHSMKDVPTALPQGIVQAAVLERANEKDILVYNN--NLDFLN 116 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 + + T SLRRQ Q + P+ + LRGNV TR+ KL + ++ + A AGL+R+ ++ Sbjct: 117 TQATIATGSLRRQAQWLHKYPNHKVVDLRGNVNTRMQKLQDNNWNGAVFAAAGLERINIK 176 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 + + +PA QGA+ + +D+ + LA LNH ET + ER LEG Sbjct: 177 PE--NYINLDWMIPAPAQGAMMVVAMGNDTYCLDALAELNHIETEITTYIERQFLRTLEG 234 Query: 241 GCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GC PIG+YA D I + ++ + DGSQ I ++ Q+ +Q+G +E+ NG Sbjct: 235 GCTAPIGAYARFNEKDETIHFQGVLFSLDGSQKIEIKKIVEIQEWKQLGYHAGQEIFENG 294 Query: 299 AREILAEVYNG 309 +++ + Sbjct: 295 GVQLMKTIKEK 305 >UniRef50_C6WZF5 Porphobilinogen deaminase n=1 Tax=Flavobacteriaceae bacterium 3519-10 RepID=C6WZF5_FLAB3 Length = 311 Score = 352 bits (905), Expect = 7e-96, Method: Composition-based stats. Identities = 107/307 (34%), Positives = 172/307 (56%), Gaps = 7/307 (2%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 ++I TR SPLALWQA V L + ++ P++++GD L PL +G G+F Sbjct: 10 RSIKIGTRNSPLALWQAREVARHLQNN--NHTTDITPIISKGDKNLSQPLYTLGITGIFT 67 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 K+L++ALL N DIAVHS+KD+P + P+ + ++ + +R+ P+D V + L Sbjct: 68 KDLDIALLNNEVDIAVHSLKDIPTQLPENVEIIAVLQRDYPQDVLVRKKDAATLELHQ-L 126 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 + TSSLRR+ + P +RGNV TRL+KL+ ++DA + ++A ++R+GL Sbjct: 127 KIATSSLRRRAFWLKEFPGTEFSDIRGNVQTRLTKLEENDFDATMFSLAAIERMGLSVD- 185 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + +PA QG V + R +D +EL +NH ET + + ER+ + LEGGC Sbjct: 186 --YEHLPLMIPAPAQGVVAVCARSNDPEIKELFKEINHRETRICIDIERSFLSTLEGGCT 243 Query: 244 VPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 PIG++AE+ D GE+ + + DG I + A + + G LAE++L NG RE+ Sbjct: 244 APIGAFAEINDLGEVRFTGRICSLDGQNCIETDEIFAWNEHDDFGKILAEKILQNGGREL 303 Query: 303 LAEVYNG 309 + E+ + Sbjct: 304 MQEIKSK 310 >UniRef50_A8U3E9 Porphobilinogen deaminase n=1 Tax=alpha proteobacterium BAL199 RepID=A8U3E9_9PROT Length = 321 Score = 352 bits (903), Expect = 1e-95, Method: Composition-based stats. Identities = 131/306 (42%), Positives = 178/306 (58%), Gaps = 7/306 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLV--VELVPMVTRGDVILDTPLAKVGGKGLFV 63 L + +R SPLAL Q H V+D+L A+ P L + + + T GD + D PLA++GGKGLF+ Sbjct: 15 LTLGSRGSPLALRQTHEVRDRLAAAWPELAGAIAVQEIRTTGDAVRDRPLAEIGGKGLFI 74 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE+E AL+ + D AVHSMKD+ LV + REDPRDA++S D +D LP+G+ Sbjct: 75 KEIEQALMAGQIDAAVHSMKDMETTIAPASVLVAVLPREDPRDAWLSPIADRVDDLPSGA 134 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +GT+S+RR Q+ RRPDL + RGNV TRL KL GE LA AGL RLG+ + Sbjct: 135 KIGTASVRRAAQVLNRRPDLQVVLFRGNVDTRLRKLAEGEVAGTFLAAAGLSRLGMLDKA 194 Query: 184 RAALPPEISLPAVGQGAVGIECR-----LDDSRTRELLAALNHHETALRVTAERAMNTRL 238 L + LPAV QGA+G++CR D+ R L+ L+ + LRVTAERAM L Sbjct: 195 TRILEVDEMLPAVSQGAIGVQCRDGEASARDAEIRNWLSILDDRPSRLRVTAERAMLATL 254 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 +G C+ PI +A L + L +V + DG A D E +G ++ E +L G Sbjct: 255 DGSCRTPIAGHATLGGARLTLSGMVFSLDGQSSHGAVDTSATDDPEALGRTVGEAILARG 314 Query: 299 AREILA 304 R LA Sbjct: 315 GRNFLA 320 >UniRef50_C7N5L0 Porphobilinogen deaminase n=2 Tax=Slackia RepID=C7N5L0_SLAHD Length = 318 Score = 351 bits (902), Expect = 2e-95, Method: Composition-based stats. Identities = 121/313 (38%), Positives = 167/313 (53%), Gaps = 5/313 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + I TR S LALWQ V +M + P + VE+ T GD+ L +PLA++G KGL Sbjct: 1 MPERFVIGTRGSKLALWQTETVGRAIMRAFPEIEVEIRVRNTTGDINLASPLAEIGDKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDA 118 F +ELE LL D+ VHS+KD+ E P+G + + R D RD V SL Sbjct: 61 FTRELETDLLLGEVDMCVHSLKDLETEQPEGCVVAGVLPRADARDVLVCGPRIQAASLAE 120 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 +P GS +GT S RR QL P+++ +RGNV TR++K + +Y+ ILA AG+KR+G Sbjct: 121 VPEGSRIGTGSRRRVAQLKANFPNMVPEGIRGNVDTRVAKAEGDDYEGAILAAAGMKRMG 180 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 E I A LP E +PA GQGA+ +E + R ++ ALN T AER + L Sbjct: 181 YEDHIAAYLPIEDMIPAPGQGAIAMEVLKKNERAYQIARALNDPVTKACTDAERFVLFSL 240 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ--DAEQMGISLAEELLN 296 EGGC PIG++ L DG+ A V + G++ R D M + EL+ Sbjct: 241 EGGCSAPIGAHCRLEDGKYIFDACVLSLGGTKAARCHLEADADSADPMDMAWEVVSELIG 300 Query: 297 NGAREILAEVYNG 309 GAR IL ++ NG Sbjct: 301 EGARAILRDIKNG 313 >UniRef50_Q11XT5 Porphobilinogen deaminase n=8 Tax=Bacteria RepID=HEM3_CYTH3 Length = 312 Score = 350 bits (899), Expect = 3e-95, Method: Composition-based stats. Identities = 125/310 (40%), Positives = 172/310 (55%), Gaps = 4/310 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 ++ +RI TR S LALWQA +V L GL ++V + T GD ILD L+K+G KGL Sbjct: 1 MNKTVRIGTRGSKLALWQAEHVAACLQTK--GLEPQIVIIDTTGDKILDQSLSKIGSKGL 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F +ELE L DIAVHS KD+ G+ ++ I ERE D VS+ Sbjct: 59 FTEELEEQLHAGTIDIAVHSAKDLQTHLKGGMYILAITERELVNDVLVSHKPIDTLKNNP 118 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 I+GTSS RR+ L + P + +RGN+ TR+ K++ G DA++LA AG+ R+G +S Sbjct: 119 DLIIGTSSTRRRALLRKFYPQAKMVDMRGNLQTRIRKMEEGACDAMLLAYAGMHRMGYDS 178 Query: 182 RIRAALPPEISLPAVGQGAVGIECRL--DDSRTRELLAALNHHETALRVTAERAMNTRLE 239 I+ L E +PA GQG + IE D + + A LN T V+AERA LE Sbjct: 179 LIKEKLSLEEFIPAAGQGTLAIEAASTLDKEKAAVIRAVLNDAATETAVSAERAFLRTLE 238 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GGC +P+ + A D + L + + DG++ +R E R DAEQ G+ LA LL +GA Sbjct: 239 GGCSIPVFALAVERDTDYLLTGGIVSLDGTKYLRKEIRFTAADAEQRGVELATVLLKDGA 298 Query: 300 REILAEVYNG 309 EILAE+ G Sbjct: 299 DEILAEIKKG 308 >UniRef50_A6DBT5 Porphobilinogen deaminase n=1 Tax=Caminibacter mediatlanticus TB-2 RepID=A6DBT5_9PROT Length = 295 Score = 350 bits (899), Expect = 3e-95, Method: Composition-based stats. Identities = 132/295 (44%), Positives = 178/295 (60%), Gaps = 8/295 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L IATR S LALWQA +VK +L + G V+L + T GD ILD PLA +GGKGLF+KE Sbjct: 3 LTIATRGSKLALWQAEWVKKRLE--NLGHEVDLKIVTTTGDKILDKPLASIGGKGLFIKE 60 Query: 66 LEVALLENRADIAVHSMKDVPVEF-PQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 +E ALL A IAVHS+KD P E+ + L + +RE D F+S +++L LP ++ Sbjct: 61 VEEALLRGEAQIAVHSLKDFPTEYNKEHFTLAAVPKREAVEDVFLSETFETLAELPHNAV 120 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL--ESR 182 VGTSS+RR QL R DL+I LRGNV TR++KL GEYDAIILA AG+KRL L E + Sbjct: 121 VGTSSIRRAMQLKAFREDLVISDLRGNVDTRINKLKKGEYDAIILAYAGVKRLNLIKEVK 180 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 L +I +PA+GQGA+GIE + D + E + LN T + VT ER L GC Sbjct: 181 YFEILDTDIMIPAMGQGALGIET-IKDEKVIEAVKPLNDLWTKIEVTIERDFIDELNLGC 239 Query: 243 QVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 P+G A++ +D I ++A + + +++I+ E + E G AEE Sbjct: 240 HAPVGVNAKIMVDDSIKIKAAILDKN-NKVIKKEMVVPFDEWENAGREFAEEFKE 293 >UniRef50_A9FDP9 Porphobilinogen deaminase n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=HEM3_SORC5 Length = 300 Score = 350 bits (899), Expect = 4e-95, Method: Composition-based stats. Identities = 152/299 (50%), Positives = 196/299 (65%), Gaps = 4/299 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + L +ATR+S LAL Q+ L A+ P L + + +VT GD D L +GGKGL Sbjct: 1 MPTELTLATRRSALALAQSRAFARSLEAAVPDLSLRELEVVTSGDKTQDRSLQDIGGKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F+KELE ALL+ RAD AVHS+KDVP E L L I REDPRDA V+ + L LPA Sbjct: 61 FIKELEEALLDRRADFAVHSIKDVPAEIAPALCLACIPAREDPRDALVTRSGALLAELPA 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ VGTSSLRR L E RPDL+I +RGNV TRL K+ +G +DA++LA+AGLKRLGLE+ Sbjct: 121 GARVGTSSLRRAVALREARPDLVIEPVRGNVDTRLRKVFDGVFDAVVLALAGLKRLGLEA 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 R L PE+SLPA+GQGA+GIECR D R++L L ET + V+AERA+ +EG Sbjct: 181 RATEVLSPEVSLPAIGQGALGIECRTADDSVRDVLGTLADAETTICVSAERAVMAAVEGS 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR----GAPQDAEQMGISLAEELLN 296 C+ P+ +YA G +WLRAL+ PDGS++ R ERR G ++AE++G L EL Sbjct: 241 CRTPVAAYAVRDGGALWLRALLAEPDGSRLRRAERRLSWPGNTREAERLGADLGAELKK 299 >UniRef50_A6GB01 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=A6GB01_9DELT Length = 322 Score = 349 bits (896), Expect = 8e-95, Method: Composition-based stats. Identities = 138/309 (44%), Positives = 182/309 (58%), Gaps = 6/309 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 LR+ TR S LALWQA+ ++D+L+A+ GL VELV +VT+GD + D PL +VGG GL Sbjct: 9 RKLRLGTRGSALALWQANMIRDRLLAAWGAQGLEVELVRVVTKGDRVTDRPLNQVGGMGL 68 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD--SLDAL 119 FVK LE LL D AVHSMKD+P P+GL L + ER DPRDAF++ +L L Sbjct: 69 FVKGLEDKLLAGEIDFAVHSMKDMPGTLPEGLTLASTPERADPRDAFLAAPGRDVTLATL 128 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 PAGS +GTSSLRR P L I +RGNV TR+ K+ GE DA++LA AGL RLG Sbjct: 129 PAGSRLGTSSLRRGALAKRINPGLEIVPIRGNVPTRMGKIAEGEVDAVLLAAAGLDRLGK 188 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 I L P+ +PA QG + IE R D+ L L H T++ AER+ L+ Sbjct: 189 GEAITERLDPDAFMPAACQGVLAIELRAADTDIAALFEPLGHGPTSIVAAAERSYLATLQ 248 Query: 240 GGCQVPIGSYAELIDG--EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 GGCQVP+ +A L + + + LV PDGS + E G DA Q+G +A E+L Sbjct: 249 GGCQVPLACHARLSEDGRRVRVEGLVVEPDGSTVYASEAEGPVADAAQLGAGVAREVLAA 308 Query: 298 GAREILAEV 306 G + ++ + Sbjct: 309 GGQGVIDRL 317 >UniRef50_C4Z552 Porphobilinogen deaminase n=8 Tax=Bacteria RepID=HEM3_EUBE2 Length = 295 Score = 349 bits (895), Expect = 1e-94, Method: Composition-based stats. Identities = 122/291 (41%), Positives = 166/291 (57%), Gaps = 5/291 (1%) Query: 7 RIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66 RI TR S LAL Q+ YVK ++ ++P ELV + T GD + D PLA +G KG FVKE+ Sbjct: 4 RIGTRGSKLALVQSEYVKRRMEEAYPEDTFELVIIKTTGDKVTDKPLAAIGTKGFFVKEI 63 Query: 67 EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126 E ALL D+AVHSMKD+P E GL +RED RD + S LP+G+++G Sbjct: 64 EEALLSGSIDMAVHSMKDMPAECAAGLTFAKAWKREDCRDVLILKTAGSFSELPSGAVIG 123 Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY--DAIILAVAGLKRLGLESRIR 184 T SLRR CQLA RPD+ ++RGNV TR++KL + Y D I+LA AGL RLG S I Sbjct: 124 TGSLRRACQLAMLRPDIQFTAIRGNVDTRINKLMDDSYGLDGIVLAAAGLNRLGRSSEIT 183 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L PE+ +PA QG + IE ++ + + AL+ + AER GGC Sbjct: 184 EYLDPEVVIPAPAQGVLAIETAEVNTELLDKINALSDDNSDREAVAERTFLRLTGGGCHA 243 Query: 245 PIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 P+G++ +G++ + L G D S+I+R E G D+E +G A L Sbjct: 244 PVGAHCVTKDNGDLRMVVLFGNDDCSRILRIEVTGT--DSEAVGHEAARML 292 >UniRef50_C0YV01 Hydroxymethylbilane synthase n=1 Tax=Chryseobacterium gleum ATCC 35910 RepID=C0YV01_9FLAO Length = 302 Score = 347 bits (892), Expect = 3e-94, Method: Composition-based stats. Identities = 108/305 (35%), Positives = 166/305 (54%), Gaps = 6/305 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +RI TR S LALWQA V L + + E+VP+V+ GD L+ PL +G G+F Sbjct: 2 KSIRIGTRNSALALWQAREVARHLQNN--NYLTEIVPIVSSGDKNLNQPLYSLGITGVFT 59 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 ++L++ALL + DIAVHS+KDVP + PQ + ++ ER+ P+D + Sbjct: 60 RDLDIALLNDEIDIAVHSLKDVPTQLPQNIEMIAYLERDYPQDILIRKESSRNKEFHE-L 118 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 + TSSLRR+ P +RGN+ TRL KL+ G++DA IL++AG+KR+ +E Sbjct: 119 KLATSSLRRRAFWLRNYPTAEFSDIRGNIQTRLQKLEEGDFDATILSLAGIKRMKMEID- 177 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + + A QG + + D E++ +NH ET + V ER + LEGGC Sbjct: 178 --YEMLPLMISAPSQGVISVAGHTDKPEINEIVRQINHQETQICVEIERNFLSTLEGGCT 235 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 PIG++AE+I +I +A + + DG I + AE G A+ +L NG +E++ Sbjct: 236 APIGAFAEIIGDQIRFKAALCSLDGKNCIAVDENFVYTPAENFGEKYAKVVLENGGKELM 295 Query: 304 AEVYN 308 AE+ + Sbjct: 296 AEIKS 300 >UniRef50_A3CL78 Porphobilinogen deaminase n=1 Tax=Streptococcus sanguinis SK36 RepID=HEM3_STRSV Length = 306 Score = 346 bits (889), Expect = 5e-94, Method: Composition-based stats. Identities = 126/300 (42%), Positives = 179/300 (59%), Gaps = 7/300 (2%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 V+++ TR+S LA+ Q + D+L A HP LVP T+GD + L ++GGKG+FV Sbjct: 2 KVIKVGTRKSKLAMTQTQQLVDQLKALHPERDFVLVPYTTKGDRLTHVSLQEIGGKGVFV 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALPAG 122 KE+E ALL ++AVHS+KD+P + +G L I +RED RD + +L LP G Sbjct: 62 KEIERALLAGEINMAVHSLKDMPAKLAEGCALGAISQREDVRDCLIFRQAGQTLADLPKG 121 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 S++GTSS+RRQ QL +RPDL + LRGN+ TR+ KL+ GEYDAI+LA+AGLKRLG + Sbjct: 122 SLIGTSSIRRQVQLQAQRPDLAFKPLRGNIDTRIKKLEEGEYDAIVLAMAGLKRLGWLDQ 181 Query: 183 IR---AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 R L + LPA+ QGA+ +ECR +D LLAA+ +TA V ERA+ ++ Sbjct: 182 SRLHIQPLETSLCLPAISQGALAVECREEDEELLSLLAAVQDEKTAAEVAVERAVLAQMN 241 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 C PI ++A+ L A++ DG Q I +G QD +Q+ +L + GA Sbjct: 242 ADCTFPIAAFAQKNGQGYQLEAMLAKEDG-QCIFVSLQG--QDGQQLAEQAVRQLADKGA 298 >UniRef50_C3PNS9 Porphobilinogen deaminase n=15 Tax=Rickettsia RepID=HEM3_RICAE Length = 351 Score = 345 bits (887), Expect = 9e-94, Method: Composition-based stats. Identities = 105/254 (41%), Positives = 156/254 (61%), Gaps = 1/254 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + N +RI TR+SPLAL + V ++ P + E+VP++T GD+I + PL +GGK L Sbjct: 1 MTNSIRIGTRKSPLALIHTNLVIQQIKQFFPDINCEIVPIITSGDLIQNKPLYDIGGKAL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F+KE+E ALL+ + D+AVHS+KDVP P+ L + + EREDPRD FV Y S++ LP Sbjct: 61 FLKEIEQALLDKKIDLAVHSLKDVPGRIPEPLVIAAVLEREDPRDVFVCLKYKSIEELPQ 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL-E 180 +++G+S++RR+ + + RPDL + RGNV +R+ KL GE DA ILA GLKRL + Sbjct: 121 NAVIGSSAVRRKAFIQKIRPDLKVTVFRGNVDSRIKKLMTGEVDATILAYTGLKRLEVFN 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 + LP +GQG + +E R DD+ E+ +NH T + ERA L+ Sbjct: 181 PEYCHLIEYSQMLPCIGQGVIAVEIRKDDNAMLEICNQINHLPTFELIKPERAFLEYLDA 240 Query: 241 GCQVPIGSYAELID 254 C+ PI +Y++ +D Sbjct: 241 NCRTPIAAYSQYLD 254 >UniRef50_D0NJW2 Porphobilinogen deaminase n=2 Tax=Phytophthora infestans T30-4 RepID=D0NJW2_PHYIN Length = 361 Score = 345 bits (886), Expect = 1e-93, Method: Composition-based stats. Identities = 124/320 (38%), Positives = 173/320 (54%), Gaps = 11/320 (3%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGK--- 59 + +++R+S LA+ Q + V L P L + T GD +LD L+ +G Sbjct: 13 KRTIFVSSRKSQLAMAQTNTVIAMLEERFPDLQFVVGQEDTVGDQVLDRHLSDLGTTTAS 72 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS------NNY 113 GLF K LE ALL A AVHS+KD+P P GL L I +RE P DA V Sbjct: 73 GLFTKSLEEALLAKAASFAVHSLKDMPTTLPDGLVLAAITKRESPEDAAVIHPKHKEKGI 132 Query: 114 DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVA 172 +L LP GS++GTSSLRR+ L + P I+++RGN+ TRL+KLD +YDAII+A Sbjct: 133 KTLQELPEGSVIGTSSLRREALLRSQFPTFEIKTVRGNIQTRLAKLDEHDDYDAIIVAAC 192 Query: 173 GLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232 G +R L RI LP + VGQG++G+ECR DD T E+L + ++A AER Sbjct: 193 GFRRGELGDRIDEILPMDTFGYGVGQGSIGVECRADDEETIEMLKTITDEKSAQLCKAER 252 Query: 233 AMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAE 292 ++ LEGGCQ+ +G A L + + L A V + DG + + G E++G LAE Sbjct: 253 SLLYHLEGGCQIAMGVSATLDEDTLTLNATVLSRDGKESVHETISGPRTQCEELGKQLAE 312 Query: 293 ELLNNG-AREILAEVYNGDA 311 NN AR++L + A Sbjct: 313 RFWNNELARKVLGKTRQKRA 332 >UniRef50_B3U3W9 Hydroxymethylbilane synthetase n=1 Tax=Oxyrrhis marina RepID=B3U3W9_OXYMA Length = 395 Score = 345 bits (885), Expect = 1e-93, Method: Composition-based stats. Identities = 129/303 (42%), Positives = 169/303 (55%), Gaps = 3/303 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMAS-HPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR SPLAL QA V+ + G +++ + T GD ILD LA VGGKGLF K Sbjct: 76 LRIGTRGSPLALAQARDVESRAREQLQQGGEIDICVISTEGDRILDRALADVGGKGLFTK 135 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 EL+ ALL D VHSMKDVP G +V RED RD F+S Y +L LP G++ Sbjct: 136 ELDRALLSGEVDCCVHSMKDVPTTVAPGTEIVAYLPREDTRDVFLSAKYATLADLPDGAV 195 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGT+SLRRQ Q+ ++ ++++ + RGNV TRL KL G D LA AGLKRLG+ + Sbjct: 196 VGTASLRRQAQILAQK-NVVVTNFRGNVQTRLRKLAAGTVDCTFLAYAGLKRLGMLAEAT 254 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L LPA+ QGAVGI+ R +D+ R L+ L+H T L V ERA L+G C+ Sbjct: 255 QVLEWSDMLPAIAQGAVGIQIRSNDAALRGTLSQLDHEPTRLAVETERAFLRALDGSCRT 314 Query: 245 PIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 PI A + D + R V + DG Q P D ++G +L ++L E Sbjct: 315 PIAGQAWIGPDSRLAFRGQVLSADGKQRFERVGDCLPCDGPELGKTLGDDLRREAGEEFF 374 Query: 304 AEV 306 AE+ Sbjct: 375 AEL 377 >UniRef50_B2W5W6 Porphobilinogen deaminase n=2 Tax=Pleosporineae RepID=B2W5W6_PYRTR Length = 399 Score = 343 bits (882), Expect = 3e-93, Method: Composition-based stats. Identities = 129/348 (37%), Positives = 177/348 (50%), Gaps = 45/348 (12%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG----KG 60 + I TR S LA QA V+ L ++P + P++ +GD TPL ++ K Sbjct: 30 PVNIGTRNSVLAQIQARAVERSLKDAYPERTYNICPVIVQGDRDKITPLQQLSQGENAKS 89 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS----NNYDSL 116 L+ ELE L DI VH +KD+P + P L L I EREDPRDA + +L Sbjct: 90 LWTGELESMLESGDLDIIVHCLKDMPTQLPDHLELGAILEREDPRDALLVSPRLPKETTL 149 Query: 117 DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAGL 174 LP G+ +GTSS+RR L + P L LRGNVGTRL+KLD + Y AIILA AGL Sbjct: 150 ATLPQGATIGTSSVRRAATLRKLYPHLKFADLRGNVGTRLAKLDAEDSPYSAIILAAAGL 209 Query: 175 KRLGLESRIRAALPPEI--SLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232 KR+GL++RI L L AVGQGA+GIE R +D +EL++ + T +AER Sbjct: 210 KRMGLDNRITQYLSSTSGGMLHAVGQGALGIEIRKNDEAMKELMSKIRCERTTRACSAER 269 Query: 233 AMNTRLEGGCQVPIGSYAELIDG------------------------------EIWLRAL 262 A+ LEGGC VPIG G E+ +RA+ Sbjct: 270 ALLRTLEGGCSVPIGVETSWKGGKGLSVGPQPAKDYDKHGNAVEEDEPDVDDQELVMRAM 329 Query: 263 VGAPDGSQIIRGERR---GAPQDAEQMGISLAEELLNNGAREILAEVY 307 V + DG + + E ++AE+MG +A+ L+ GA +IL ++ Sbjct: 330 VVSVDGKESVEYEATRKVRNAEEAEEMGREVAKILIEKGADKILEKIN 377 >UniRef50_UPI00006CBE06 porphobilinogen deaminase family protein n=1 Tax=Tetrahymena thermophila RepID=UPI00006CBE06 Length = 362 Score = 343 bits (881), Expect = 4e-93, Method: Composition-based stats. Identities = 125/339 (36%), Positives = 181/339 (53%), Gaps = 32/339 (9%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLM-ASHPGLV---VELVPM--------------- 41 + + +IA+R S LAL Q + V D L+ GL E+VP+ Sbjct: 16 LKNRKFKIASRSSQLALSQTYEVIDLLVGVKELGLTKENFEVVPISNAPGKNCTLKFKIN 75 Query: 42 ------VTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGL 95 +GD L PL +GG G+F K +EV LL DIAVHS+KD+P + L + Sbjct: 76 ITNKQFTNKGDQNLKDPLYVMGGVGVFTKIVEVELLNKNGDIAVHSLKDLPTIIDERLFI 135 Query: 96 VTICEREDPRDAFVS---NNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNV 152 + + D + + L LP GS++GTSSLRR L R P L ++RGN+ Sbjct: 136 GAVPPLKPRGDVVIFNEKHKGKELKDLPEGSVIGTSSLRRITNLKNRYPHLKYENIRGNL 195 Query: 153 GTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRT 212 TRL+KL+NG+YDAIILA AG+ RLG ++ L E L A GQGA+G++CR DD Sbjct: 196 NTRLTKLENGQYDAIILAEAGVFRLGWIEKVGQFLKQEDFLYAPGQGALGVQCRADDKEA 255 Query: 213 RELLAALNHHETALRVTAERAMNTRLEG---GCQVPIGSYAELIDGEIWLRALVGAPDGS 269 LL+ +N E +RV AER +LEG GC++PI ++E+ID + L V + + Sbjct: 256 IALLSYINQKEPRIRVDAERQFLNKLEGVILGCKLPIAVHSEIIDQTLRLTGQVWSLEAD 315 Query: 270 QIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYN 308 + IR G D + +G+ L+E++ GA EIL ++ + Sbjct: 316 KTIREVIEGHISD-QDLGLKLSEKMKQAGAGEILEKIRS 353 >UniRef50_Q1V167 Hydroxymethylbilane synthase n=3 Tax=Candidatus Pelagibacter RepID=Q1V167_PELUB Length = 307 Score = 343 bits (881), Expect = 4e-93, Method: Composition-based stats. Identities = 111/300 (37%), Positives = 168/300 (56%), Gaps = 3/300 (1%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVE---LVPMVTRGDVILDTPLAKVG 57 M + + I +R S LAL A ++K++ +E + +VT+GD + D L++VG Sbjct: 1 MKNRKIIIGSRGSKLALIYAEKAREKILKHSKDFGIEEVIIKEIVTKGDQVQDKRLSEVG 60 Query: 58 GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD 117 GKGLF K +EV LLE + DIAVH++KD+P E +GL ER DPR+ +S + L Sbjct: 61 GKGLFSKTIEVELLEKKIDIAVHALKDMPSEETRGLLTDCFLERNDPREILISKDNKHLK 120 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177 L + SI+GTSS RR+ Q+ + R DL + +RGNV TR+ KL YDAIIL+ AG+ L Sbjct: 121 DLASNSIIGTSSYRREFQIKKIRDDLNCKLIRGNVDTRIRKLKENLYDAIILSYAGIDSL 180 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 GL I +P GQG + ++CR +D ELL ++H T + AER + Sbjct: 181 GLNQNISQTFSTSEIIPCAGQGVIALQCRDNDESLIELLKQVDHQSTHSSIKAERNVLKV 240 Query: 238 LEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 LEG C+ +G++A + +I L + + DGS+ + + AE++GI + + L Sbjct: 241 LEGDCETAVGAFANIEGNKINLEVELFSLDGSKRFYLKSSESVDKAEELGIEMGKTLKKM 300 >UniRef50_A3ZKX4 Porphobilinogen deaminase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A3ZKX4_9PLAN Length = 308 Score = 343 bits (880), Expect = 5e-93, Method: Composition-based stats. Identities = 133/302 (44%), Positives = 184/302 (60%), Gaps = 5/302 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +RI TR S LA WQA++V D+L A G VE++ + T+GDV PL +GG+G+F Sbjct: 3 AIRIGTRGSQLAQWQANWVADQLRAV--GTDVEIIHIATQGDVTQ-GPLDLIGGRGVFTT 59 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E++ ALL+NR D+AVHS+KD+P E GL L + R D +++ + LP SI Sbjct: 60 EIQAALLDNRIDVAVHSLKDLPTEAVVGLRLAAVPARGADGDVLITSKASDVLGLPQESI 119 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GT S+RR+ QL R D IR +RGN+ TRL KLD+G YDAIILA AGL+RL L RIR Sbjct: 120 IGTGSMRRKAQLLHLRRDFQIRDIRGNLDTRLRKLDDGLYDAIILAEAGLRRLELIERIR 179 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 +P LPAVGQGA+G+E R DS T +LA LNH ++ V AER+M L GGC Sbjct: 180 HVIPKAQMLPAVGQGALGLEIRERDSATAAMLAPLNHEDSHYSVLAERSMLRNLRGGCLA 239 Query: 245 PIGSYAELI--DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 P+G++ + ++L +V + DG + G P AE +G +A++L GA + Sbjct: 240 PVGAWGRIDPIKQLLFLDGVVVSGDGHHKVTASACGPPNRAEDIGRQVADQLAIQGAERL 299 Query: 303 LA 304 +A Sbjct: 300 IA 301 >UniRef50_C4ZFT9 Porphobilinogen deaminase n=1 Tax=Eubacterium rectale ATCC 33656 RepID=C4ZFT9_EUBR3 Length = 338 Score = 342 bits (879), Expect = 8e-93, Method: Composition-based stats. Identities = 113/309 (36%), Positives = 161/309 (52%), Gaps = 39/309 (12%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67 I TR S LAL Q YV DKL ++P + V + T GD+ L K+G KG+FVKE+E Sbjct: 5 IGTRGSKLALVQTDYVIDKLKRAYPDDDFKAVIIKTTGDLEQKKALDKIGSKGIFVKEIE 64 Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127 LL + +AVHSMKD+P E GL +REDPRD V N SLD LP G+++GT Sbjct: 65 DELLSGKIHMAVHSMKDMPDEPAAGLTFAKAWKREDPRDVLVLKNAASLDELPHGAVIGT 124 Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE------------------------ 163 S RR+ QL + RPDL + +RGN+ TRL KL +GE Sbjct: 125 GSKRRKYQLLKLRPDLKVVGIRGNIDTRLRKLYDGEIIYEEVADNTVNNNEIANEKKNKY 184 Query: 164 ----YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAAL 219 D I+LA AG+KR+G +S I + +PA QG + +E R D+++ L AL Sbjct: 185 SEYRLDGIVLAAAGIKRIGRDSEITQYFSEDDMIPAPAQGTLALELRADNAKLMAKLDAL 244 Query: 220 NHHETALRVTAERAMNTRLEGGCQVPIGSYAELI-----------DGEIWLRALVGAPDG 268 + +T L ER ++ G C +P+ +Y +++ + + L A+ G+ DG Sbjct: 245 SDEKTNLCAGIEREFLKQIGGNCHLPVAAYCDIVSEKDRGNDSNKNNRLKLLAMFGSEDG 304 Query: 269 SQIIRGERR 277 Q+ R E+ Sbjct: 305 KQLARTEQV 313 >UniRef50_A8MDU3 Probable porphobilinogen deaminase n=2 Tax=Thermoproteaceae RepID=HEM3_CALMQ Length = 305 Score = 342 bits (878), Expect = 9e-93, Method: Composition-based stats. Identities = 124/304 (40%), Positives = 179/304 (58%), Gaps = 2/304 (0%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 ++RIATR S L+L Q V D+++ + + +L+ + T GDV L PL ++G KG+F + Sbjct: 2 IIRIATRGSALSLKQTKIVMDRILEFNKDVEFKLIIVKTTGDVDLSKPLYEIGVKGIFER 61 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E+ A+L AD+AVHS+KD+P + L LV R++PRDA VS ++D LP SI Sbjct: 62 EVNQAVLRGEADVAVHSLKDMPAQISNDLTLVMTPPRDNPRDALVSLRQYTVDTLPLNSI 121 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGTSSLRR+ L R D+ ++ +RGNV TR+ KL+NGEYDA+I+A AGL+RL + + + Sbjct: 122 VGTSSLRRRGFLLSLRRDVTVKPIRGNVDTRIRKLNNGEYDALIMAAAGLERLSINANVS 181 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 PE+ PA GQG +G+ R D ++L + ET AERA +R+ GC V Sbjct: 182 EI-SPELMPPAPGQGIIGVVARRDRDDLIKVLRRSSDEETFKEAAAERAFLSRIGAGCHV 240 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 P+G A L DG V PDG + R ++ E+ G AE+LL N AR ++A Sbjct: 241 PLGGLALLDDGYFDFTYGVVDPDGVEKFINSTRIDARNPEEAGRVAAEDLLRN-ARGLVA 299 Query: 305 EVYN 308 + Sbjct: 300 RLLK 303 >UniRef50_A0LRF1 Porphobilinogen deaminase n=1 Tax=Acidothermus cellulolyticus 11B RepID=HEM3_ACIC1 Length = 331 Score = 341 bits (876), Expect = 2e-92, Method: Composition-based stats. Identities = 128/313 (40%), Positives = 165/313 (52%), Gaps = 6/313 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +VLR+ TR+S LA Q + L A+ G VE+V + + GD D PL + G G+FV Sbjct: 8 SVLRLGTRRSTLARAQTEEIAGALRAA--GCRVEIVGIQSTGDRHADVPLHEFAGSGVFV 65 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 EL ALL D+ VHSMKD+P L + I R DPRDA V+ L LP G+ Sbjct: 66 AELRAALLRGEVDVVVHSMKDLPTAEIPELAIAAIPRRADPRDALVTGAGCRLAELPTGA 125 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 IVGT S RR QL RPDL IR +RGN+ TRL KL G Y A+I+A AGL RL Sbjct: 126 IVGTGSPRRAAQLRLLRPDLEIRPIRGNLDTRLGKLHAGGYAALIVAAAGLARLHRSEEA 185 Query: 184 RAALPPEISLPAVGQGAVGIECR----LDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 P + LPA GQGA+ +ECR D R +LA L+ T VTAERA+ + Sbjct: 186 AEFFDPTVMLPAPGQGALAVECRRADIADGGRLAGILAGLDDPATRAAVTAERALLAAVG 245 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GC P+G+ + + L A+V P G+ R G P DA +G LA +L+ GA Sbjct: 246 AGCSAPVGALGVVTADTLQLDAVVVDPSGTTAFRRSLTGTPDDASDLGRRLAADLIRAGA 305 Query: 300 REILAEVYNGDAP 312 ++L P Sbjct: 306 DQLLQAPKQTGEP 318 >UniRef50_A2Q9P7 Catalytic activity: 4 porphobilinogen+H(2)O<=>hydroxymethylbilane+4 NH(3) n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2Q9P7_ASPNC Length = 346 Score = 341 bits (875), Expect = 2e-92, Method: Composition-based stats. Identities = 121/324 (37%), Positives = 173/324 (53%), Gaps = 22/324 (6%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG-----KG 60 LR+ TR S LAL QA +V +L ++HPG+ +V RGD +P K G K Sbjct: 12 LRLGTRNSKLALVQAEHVSKELTSAHPGVQFPWQTVVVRGDADKSSPFLKFAGPSDAAKN 71 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-----YDS 115 ++ +E+E L D+ VH +KD+P P+ L I REDP DA V Y Sbjct: 72 IWTEEMETKLCAGELDLLVHCLKDMPTRLPETCTLGAIVYREDPTDALVIKEGLRSQYTD 131 Query: 116 LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAG 173 L LP GS+VGTSS RR+ L R P L + RGN+GTRL KLD G + AIILA AG Sbjct: 132 LSQLPPGSVVGTSSTRRKALLRYRYPHLKVEECRGNLGTRLKKLDDPEGPFSAIILATAG 191 Query: 174 LKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERA 233 + R+ LE RI LPP AVGQGA+GIE R +D++T+ ++ + T AER+ Sbjct: 192 MVRINLEDRITKRLPPSEFPYAVGQGALGIEIRKEDAQTKTMVRKIEDLVTRRICLAERS 251 Query: 234 MNTRLEGGCQVPIGSYAELID-------GEIWLRALVGAPDGSQIIRGERR---GAPQDA 283 + L+GGC P+ + + ++ L + P G+ ++ G +DA Sbjct: 252 LLRTLQGGCSSPVAVHCTVEQAPTASSPAQLRLDGTIIHPHGTTLLSERTTAEVGTDEDA 311 Query: 284 EQMGISLAEELLNNGAREILAEVY 307 E +G ++A++LL NG + +L E+ Sbjct: 312 EALGATVAQQLLKNGGQALLEEIR 335 >UniRef50_C1ZK04 Porphobilinogen deaminase n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZK04_PLALI Length = 318 Score = 340 bits (873), Expect = 4e-92, Method: Composition-based stats. Identities = 139/315 (44%), Positives = 181/315 (57%), Gaps = 16/315 (5%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 VLRIATR S LALWQA++V D L + P L VELV + T GD + PL + GG+G+F + Sbjct: 3 VLRIATRASQLALWQANFVADSLRSLDPELTVELVHVTTTGDRVQGEPLRQFGGQGVFTR 62 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS----LDALP 120 E++ ALLE RADIAVHS+KD+P GL L + R DA + S L LP Sbjct: 63 EVQAALLEGRADIAVHSLKDLPTVPTAGLELAAVPARAPVADALLLPTGHSGPASLAMLP 122 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GT S RRQ QL RPDL+ +RGN+ TR+ KLD GEY+ +ILAVAGL RLG Sbjct: 123 RGARIGTGSPRRQAQLLRIRPDLVCSEVRGNLDTRIRKLDAGEYEGLILAVAGLSRLGWS 182 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 RI L P PA GQGA+G+ECR D T ++ L +T L V AERA+ LE Sbjct: 183 DRISLILAPPTMFPAAGQGALGLECRHGDEATIRWVSQLEDRQTRLAVDAERAVLRTLEA 242 Query: 241 GCQVPIGSYAELID-GEIWLRALVGAPDGSQIIRG--ERRGAPQD---------AEQMGI 288 GC P+G++A + L A++ APDGS+ + +G A ++G Sbjct: 243 GCHAPVGTWASWKSPETLHLEAILIAPDGSETLAAASSMQGPLSQYGSGNALDAAHELGA 302 Query: 289 SLAEELLNNGAREIL 303 ++A LL GA L Sbjct: 303 NVAHLLLKQGASRYL 317 >UniRef50_B8MVK7 Porphobilinogen deaminase, putative n=1 Tax=Talaromyces stipitatus ATCC 10500 RepID=B8MVK7_TALSN Length = 413 Score = 339 bits (871), Expect = 6e-92, Method: Composition-based stats. Identities = 124/337 (36%), Positives = 172/337 (51%), Gaps = 36/337 (10%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGL-VVELVPMVTRGDVILD---TPLAKVGG- 58 +R+ +R S +AL Q V L +H G + +GD LAK G Sbjct: 72 KAVRVGSRNSKMALIQTSSVAAALYKAHHGFFTFPVSTHSVQGDRDKTSAFRDLAKAHGN 131 Query: 59 --------KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS 110 K L+ E+E LL D+ VHS+KDVP P G + R DP DA + Sbjct: 132 KQTAADTAKSLWTLEIEARLLAGDIDLIVHSLKDVPTTLPDGCEIGAFPHRNDPTDALLV 191 Query: 111 NN---YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YD 165 Y SL+ LPAGS+VGT S+RR QL P LII+ RGNV TR++KLD + Y Sbjct: 192 KAGLPYKSLEELPAGSVVGTCSVRRTAQLRHYCPHLIIQECRGNVDTRVAKLDANDSPYT 251 Query: 166 AIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETA 225 AI++A AG+ RL LE RI L AVGQGA+GIE R +D + REL+A ++H T Sbjct: 252 AIVVAAAGIVRLNLEHRITQRLSGPAYTYAVGQGALGIEIRKEDQKARELVACIDHWPTR 311 Query: 226 LRVTAERAMNTRLEGGCQVPIGSYAELI---------------DGEIWLRALVGAPDGSQ 270 +R AERA+ L+GGC PIG ++ + +G ++L + PDG Sbjct: 312 VRCLAERALLRFLQGGCSAPIGVHSAFVRTPAKGEPNVNDNHYEGTLYLTGTLLHPDGGM 371 Query: 271 IIRGERRG---APQDAEQMGISLAEELLNNGAREILA 304 IR +G D+E +G S+ +++L+ G +IL Sbjct: 372 EIRAHEKGQVKCTADSETIGKSVGKKILDLGGAQILD 408 >UniRef50_A5CDH4 Porphobilinogen deaminase n=2 Tax=Orientia tsutsugamushi RepID=HEM3_ORITB Length = 298 Score = 339 bits (871), Expect = 6e-92, Method: Composition-based stats. Identities = 124/292 (42%), Positives = 161/292 (55%), Gaps = 3/292 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 ++R+ +R S LAL QA V K+ GL ++P+ T GD+I + L +GGKGLF+K Sbjct: 2 IIRVGSRASRLALIQAQAVVQKINDL-LGLNAIIIPIKTTGDLIQNKNLYDIGGKGLFLK 60 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E+E ALL N DIAVHS+KDVP P GL L + ER D D VS + + LP G+I Sbjct: 61 EIEYALLNNTIDIAVHSLKDVPAYLPDGLQLAAVLERGDVGDMLVSKIANKITDLPLGAI 120 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE-SRI 183 VGTSS+RR+ QL RPDL I RGNV TR +K+ N E DA +LA AGL+RL + SR Sbjct: 121 VGTSSVRRRIQLLMLRPDLNIVLFRGNVDTRWNKIINNEVDATVLAAAGLQRLNYDTSRF 180 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 +P LPA+GQGA+ IE R DD L A +NH T + ER L C Sbjct: 181 CNIIPQSEMLPAIGQGAIAIEARKDDKLIMPLCAKINHQLTWQLIQVERGYLKTLNADCN 240 Query: 244 VPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 VPIG A I + ++G + E RG Q +G+ A+ Sbjct: 241 VPIGGIASYIGNNSFEAKFMLGDYNMRYFFYSEVRGKLQHGYDIGVEAAKNF 292 >UniRef50_Q0TQG4 Porphobilinogen deaminase n=32 Tax=Clostridium RepID=HEM3_CLOP1 Length = 291 Score = 339 bits (870), Expect = 8e-92, Method: Composition-based stats. Identities = 128/292 (43%), Positives = 170/292 (58%), Gaps = 4/292 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L IATR+S LA Q V + L + + + ++T GD LD L K+GGKGLFVKE Sbjct: 3 LIIATRKSKLAQVQTEKVMELLKEKE-NVDSKKLLVMTEGDRRLDVSLNKIGGKGLFVKE 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E+ALL A AVHSMKDVP E P LV + ERED RDAFVS N +L L G+ + Sbjct: 62 IELALLNKEAHGAVHSMKDVPFELPSEFELVAMPEREDIRDAFVSLNGSTLSNLRKGARI 121 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR QL R DL I +RGNV TR+ K+ D IILA AGLKRLG+E I Sbjct: 122 GTSSIRRAEQLKLFRDDLEIVPIRGNVQTRIKKITEENLDGIILAAAGLKRLGMEDVISD 181 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 P++ LPA+GQGA+GIEC + AL+ E V AER+ L GGC Sbjct: 182 YFDPKVFLPAIGQGALGIECLKGG-EFNDYFKALDSKEVRTTVEAERSFMKVLNGGCHSL 240 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 IG+Y+E+ D ++++ ++I++ + G +D +G LAE++L Sbjct: 241 IGAYSEVKDNDLYMIGTFTV--NNRIVKKDILGNKEDNILLGKKLAEKILGE 290 >UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia (class) RepID=B9L0Q4_THERP Length = 560 Score = 338 bits (868), Expect = 1e-91, Method: Composition-based stats. Identities = 125/295 (42%), Positives = 163/295 (55%), Gaps = 4/295 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + +RI +R S LAL Q V ++L P V +VP+VT GD T L +GG G+ Sbjct: 1 MAARIRIGSRGSTLALAQTEEVVERLRRLVPECSVTVVPIVTTGDRDRATSLTVLGGSGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F KEL ALL D+AVHS KD+P + P GL LV + RED RD V++ L LPA Sbjct: 61 FAKELHEALLAGTIDLAVHSAKDLPTQLPPGLVLVAVLAREDARDVLVTSPPRKLGELPA 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ VGTSS RRQ L RPDLI+ +RGNV TRL KL G DA++L AGL+RL Sbjct: 121 GARVGTSSRRRQALLQRARPDLIVVDIRGNVDTRLRKLREGIVDALVLGAAGLRRLSQAD 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + L P+ +PA GQGA+ + R D R ELL+ L+ V ERA G Sbjct: 181 LVAEYLDPDEFVPAPGQGALAVVARESDGRL-ELLSRLDEPLVHEAVAVERAFLAAFGSG 239 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDG---SQIIRGERRGAPQDAEQMGISLAEE 293 C VP+G+YA + + R V PDG SQ + R A + A ++G++LA Sbjct: 240 CSVPLGAYATIAGNRLRFRIAVLLPDGRFISQCLDWPREEAIERARELGLTLATR 294 >UniRef50_B5G8F1 Porphobilinogen deaminase n=1 Tax=Streptomyces sp. SPB74 RepID=B5G8F1_9ACTO Length = 314 Score = 338 bits (867), Expect = 2e-91, Method: Composition-based stats. Identities = 128/314 (40%), Positives = 172/314 (54%), Gaps = 13/314 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR SPLAL Q V L P L +E+VP+ T+ D LA++GGKGLFV+E Sbjct: 1 MRIGTRSSPLALAQVEQVSGLLRKFEPDLDIEVVPVTTKADKWQGD-LAQLGGKGLFVRE 59 Query: 66 LEVALLENRADIAVHSMKDVP--VEFPQGLGLVTICEREDPRDAFVSNNY---DSLDALP 120 ++ L + D+AVH MKDVP V P+GL R+D RD + SL LP Sbjct: 60 IDQMLQRGQVDMAVHCMKDVPGDVPMPRGLIFAAYLPRDDVRDVLLVPEGSDVQSLAGLP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD-----NGEYDAIILAVAGLK 175 G+ V TS++RR+ Q+ RPDL + +RG VG+R+ KLD + DA++LA AGL+ Sbjct: 120 PGASVATSAVRRKAQINRVRPDLNVVRVRGLVGSRIDKLDGRKPMDHMLDAMVLARAGLE 179 Query: 176 RLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235 RL L R R LPAVG GA+G+ECR DD LL LN T +TAER M Sbjct: 180 RLDLMHRARQVFEVAEMLPAVGAGALGLECREDDDAVAYLLQQLNDEPTMTEITAERVML 239 Query: 236 TRLEGGCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRG-APQDAEQMGISLAEE 293 L G C PI + DG++ LR +V + DGS+ + G + D +G + E Sbjct: 240 HGLRGHCNSPIAGHCVTDPDGQLSLRGMVFSRDGSKFVHAHFWGESMNDPAVLGSRVCAE 299 Query: 294 LLNNGAREILAEVY 307 LL GAR+I+ + Sbjct: 300 LLRQGARDIIEGIP 313 >UniRef50_C1AA38 Porphobilinogen deaminase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1AA38_GEMAT Length = 309 Score = 337 bits (866), Expect = 2e-91, Method: Composition-based stats. Identities = 153/312 (49%), Positives = 188/312 (60%), Gaps = 8/312 (2%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M+ +RI TR S LAL QA V +L A G+ ELV T GD ILD PL+ +G KG Sbjct: 1 MMTVPVRIGTRSSELALRQARQVAAQLDAR--GVPSELVEYTTLGDRILDRPLSAIGEKG 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLD 117 LF ELE LL R D AVHS+KD+P PQG+ +V + EREDPRDA V SLD Sbjct: 59 LFTAELEADLLAGRIDCAVHSLKDLPTADPQGIIVVALLEREDPRDALVVRAGVDAHSLD 118 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177 LP G+ VGTSSLRR+ QL R DL + LRGNVGTRL KLD G+ DA +LA AGL RL Sbjct: 119 TLPEGARVGTSSLRRRAQLQALRSDLEVCELRGNVGTRLRKLDEGQVDAALLAAAGLHRL 178 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 GL RI A L L A GQGA+ ++ R DD L++L+H T + VTAERA+ Sbjct: 179 GLADRIVAYLDAPEWLSAPGQGAIAVQGRADDEALLSTLSSLDHAPTRVAVTAERALLAA 238 Query: 238 LEGGCQVPIGSYAELIDGE--IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295 LEGGCQVPIG+ A L + E L A++ + DGS +RG + GI LA +L Sbjct: 239 LEGGCQVPIGA-AVLEEPEYGTILHAVIVSLDGSSAVRGGYPVDHANPAASGIELARQLR 297 Query: 296 NNGAREILAEVY 307 G +IL+E+ Sbjct: 298 AAGGAQILSEIR 309 >UniRef50_Q82P95 Porphobilinogen deaminase 2 n=14 Tax=Actinomycetales RepID=HEM32_STRAW Length = 314 Score = 336 bits (863), Expect = 5e-91, Method: Composition-based stats. Identities = 124/307 (40%), Positives = 168/307 (54%), Gaps = 4/307 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 ++RI +R SP+AL Q V+ +L A HP E+V + T GD + L+KV GKG F Sbjct: 8 ELIRIVSRDSPMALAQVARVRAELAALHPRTRTEVVAVKTTGDKWMGD-LSKVDGKGAFT 66 Query: 64 KELEVALLENRADIAVHSMKDVPV--EFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 KE++ ALL AD+AVH +KDVP P G +R+D RDA V +LD LP Sbjct: 67 KEVDAALLAGEADLAVHCVKDVPADRPLPAGTMFAAFLKRDDIRDALVHPGGLTLDELPP 126 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ +GTSS+RR QLA P L RGN RL KL GE DA++LAV+GL+R+G E Sbjct: 127 GTRIGTSSVRRVAQLAAAYPHLECVPFRGNANRRLEKLAAGEADALLLAVSGLERIGRED 186 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 I L PE +P +G G + ++CR D+ E ++ L T TAER L+G Sbjct: 187 VITEVLEPETMMPPIGAGILALQCREGDTGLIETISELGDPGTHREATAERMFLHVLQGH 246 Query: 242 CQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 C PI YA +GE+ LRA V DG ++ D +G S+A LL GAR Sbjct: 247 CNSPIAGYARTERNGELSLRASVFTLDGKTVLNAHEWAGRLDPATLGTSVAVALLRQGAR 306 Query: 301 EILAEVY 307 E++ ++ Sbjct: 307 ELIDDIP 313 >UniRef50_Q8TXC8 Probable porphobilinogen deaminase n=1 Tax=Methanopyrus kandleri RepID=HEM3_METKA Length = 298 Score = 333 bits (855), Expect = 5e-90, Method: Composition-based stats. Identities = 122/299 (40%), Positives = 175/299 (58%), Gaps = 3/299 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHP-GLVVELVPMVTRGDVILDTPLAKVGGKG 60 + +R+ATR S LA+ Q V + L P + VE+V +RGDV+ D PL K+G KG Sbjct: 1 MSETIRVATRSSRLAIIQTREVIELLERESPRDVEVEIVKTKSRGDVVRDRPLHKLGEKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 +FVKE++ +LE +ADIAVHS KDVP + + + R DPR+ VS + L LP Sbjct: 61 VFVKEVDRLVLEGKADIAVHSAKDVPSVVDYPVDVAAVPPRRDPRECLVSRHG-GLKELP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGTSS RR+ Q+ RPDL + +RGNV TR+SK+ EYDA +LA GL RLG+ Sbjct: 120 RGATVGTSSPRRRAQILLERPDLKVEPMRGNVDTRVSKVRRREYDAAVLAKVGLDRLGMT 179 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 S + PE +P GQGA+ I CR DD R + LL ++ ++ + V E+A+ L Sbjct: 180 SEVSEVYDPEEFVPPAGQGALMITCRKDDDRVKRLLEVVDDEKSRVEVETEKAVVRELGV 239 Query: 241 GCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GC P+G + DG+ + L + DGS + RG+P+D + +S A E+L++G Sbjct: 240 GCSEPVGVHVRARDGDHVRLVLGLFEEDGSCGHVLKMRGSPEDVVREAVSQAREVLSDG 298 >UniRef50_A4QB59 Porphobilinogen deaminase n=15 Tax=Corynebacterium RepID=HEM3_CORGB Length = 302 Score = 333 bits (855), Expect = 5e-90, Method: Composition-based stats. Identities = 118/304 (38%), Positives = 171/304 (56%), Gaps = 8/304 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 L+I TR S LA QA ++D+L + G EL + T GDV + +P+ ++G G+F + Sbjct: 2 TLKIGTRGSKLATTQAGTIRDQLK--YFGRDAELHIVTTPGDVNM-SPVERIG-VGVFTQ 57 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L L D+AVHSMKD+P LV + R D R+A ++ + +L LP G+ Sbjct: 58 ALRDVLHAGECDVAVHSMKDLPTAADPRFHLV-VPTRADSREALIARDGLTLAELPEGAK 116 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGTS+ RR QL RPDL I LRGN+ TR+ K+ +GE DA++LA AGL R+G++ R Sbjct: 117 VGTSAPRRISQLKAIRPDLEILPLRGNIDTRMGKVTSGELDAVMLAYAGLTRVGMQDRAT 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 +I +PA QGA+ IECR DD+ T L L H +T + AER + RLE GC Sbjct: 177 EVFDADIIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVLNRLEAGCTA 236 Query: 245 PIGSYAELI---DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 P+ ++A L + L A V A DGS + G E++G +A++L++ GA Sbjct: 237 PVAAHATLDGYSGDTMTLTAGVYALDGSDQLVFSAEGDGARPEELGELVAQQLIDAGAAN 296 Query: 302 ILAE 305 +L + Sbjct: 297 LLGD 300 >UniRef50_A2BL26 Probable porphobilinogen deaminase n=2 Tax=Thermoprotei RepID=HEM3_HYPBU Length = 303 Score = 332 bits (853), Expect = 8e-90, Method: Composition-based stats. Identities = 127/298 (42%), Positives = 167/298 (56%), Gaps = 3/298 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LR+ATR S L++ Q + + P L ELV + TRGD+ D P +GGKGLF KE Sbjct: 3 LRVATRGSKLSIAQTMIALEAIKRVEPSLEYELVIVKTRGDIHQDKPFTAIGGKGLFEKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY--DSLDALPAGS 123 + +A+LE RADIAVHS+KDVP GL L R+ P D V ++ LP+G+ Sbjct: 63 VNLAVLEGRADIAVHSLKDVPSAISPGLVLAMTPPRDPPYDVLVVRGGKEKTIWDLPSGA 122 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 IVGTSS RR L R DL+ + LRGNV TRL KL+ G+YDAI+LA AGLKRLG++ Sbjct: 123 IVGTSSARRVAMLKHVRRDLVFKVLRGNVDTRLRKLEQGQYDAIVLAEAGLKRLGVDIEY 182 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 PP+I PA GQG +G+ S +L + + AERA GGC Sbjct: 183 WRI-PPDILPPAPGQGIIGVYTLSSRSDILPILEKASDQKAMAEARAERAFLAYAGGGCH 241 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 P+G+YAEL ++ A + +PDGS+ + G P Q+G+ A EL ARE Sbjct: 242 TPLGAYAELRGNTLYFHAALASPDGSRRVEVRVEGDPDKPTQVGLEAAFELRRLAARE 299 >UniRef50_D0J8N1 Porphobilinogen deaminase n=2 Tax=Blattabacterium RepID=D0J8N1_BLASP Length = 310 Score = 332 bits (852), Expect = 1e-89, Method: Composition-based stats. Identities = 99/306 (32%), Positives = 151/306 (49%), Gaps = 7/306 (2%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 ++ ++RI TR SPLA+ QA V+ L G L + + GD+I + PL K G+ Sbjct: 1 MNKIIRIGTRNSPLAISQAIEVQKVLHRL--GYCSHLFFIKSEGDLIQNIPLYKFKKVGI 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS-LDALP 120 F + L LL + D+AVHS+KDVP P+ + L +R D + + L Sbjct: 59 FTRNLTDVLLSGKIDMAVHSLKDVPTSLPEKIVLSAYLKRGSFSDLLIYQGSSNFLLNSK 118 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 +++ T SLRR+ R P I LRGN+ TRL KL N + I A GL+RLGL Sbjct: 119 IEAVIATGSLRRRAFWKNRYPHHTIVDLRGNINTRLKKLYNNSWKGAIFAKVGLERLGLL 178 Query: 181 SRIRAALP--PEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 + + + +P+ GQG + + R D+ L L+ T L ER L Sbjct: 179 NDLEGFNFKVLDWMIPSPGQGIIVVSTRKDNEWIHYLTKELDDRNTRLSANIERQFLKTL 238 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GGC PIG++A + + I+ ++ + DG Q IR ++ G + +G A+E+L G Sbjct: 239 GGGCVTPIGAHAIIKNKIIYFTGILFSLDGMQKIRKKKIGT--NYNVIGYQCAKEILEEG 296 Query: 299 AREILA 304 ++IL Sbjct: 297 GKKILE 302 >UniRef50_C1F251 Hydroxymethylbilane synthase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F251_ACIC5 Length = 312 Score = 332 bits (852), Expect = 1e-89, Method: Composition-based stats. Identities = 138/321 (42%), Positives = 178/321 (55%), Gaps = 37/321 (11%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAK----VGGKG 60 ++RI +R S LALWQA+++ +L + +E+ + T GD + AK +GGKG Sbjct: 1 MMRIGSRGSQLALWQANHIAARLRTLGHEVTIEI--IRTTGDALQHVTFAKVSTELGGKG 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 +F KE+E AL E R D+AVHS+KD+P + L I ER DPRDA +S Y SL +LP Sbjct: 59 IFTKEIEEALREGRIDLAVHSLKDLPTDLDPAFTLAAIPERVDPRDALLSARYTSLASLP 118 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGTSS RR+ QL R DL + RGNV TR+ K+ G+ DAIILA AGL+RLGL Sbjct: 119 HGACVGTSSERRRAQLLVHRSDLRFQEFRGNVDTRIRKMVEGQADAIILASAGLERLGLT 178 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R L PEI PA GQGA+ IE R DD+ T +LA+L+H T VTAER L G Sbjct: 179 EYRRECLAPEILCPAAGQGALAIETRADDAETLAILASLDHSATRYAVTAERTALASLGG 238 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ------------------- 281 GCQVPIG + + G DG+ I+G GA Sbjct: 239 GCQVPIGIHCAPVPG----------ADGAYAIQGVVAGAAAKAASSAAHPVIRVAFEHQQ 288 Query: 282 --DAEQMGISLAEELLNNGAR 300 + +G LAEELL GA+ Sbjct: 289 GLSPQALGRQLAEELLRQGAQ 309 >UniRef50_C8WIZ2 Porphobilinogen deaminase n=2 Tax=Coriobacteriaceae RepID=C8WIZ2_EGGLE Length = 327 Score = 332 bits (852), Expect = 1e-89, Method: Composition-based stats. Identities = 137/318 (43%), Positives = 183/318 (57%), Gaps = 13/318 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LALWQAH+V D L A+ PG+ V + + T+GD IL L+K+G KGLF KE Sbjct: 4 MRIGTRGSKLALWQAHHVADLLRAASPGMDVSVEVVKTKGDRILGVALSKIGDKGLFTKE 63 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE AL + R D+ VHSMKDVP P+GL L R D RD V+ + + LPAGS V Sbjct: 64 LEQALFDGRVDVCVHSMKDVPTALPEGLALAGCLIRADARDVLVAASGTTFAGLPAGSRV 123 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT +LRR QL R DL +RGN+ TR++K+ +G DA++LA AG++R+G + + Sbjct: 124 GTGALRRLSQLRAVRDDLDYVEVRGNLDTRIAKVRDGALDAVVLAAAGIERMGWSAEVAE 183 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 A + +PAVGQGA+G+E R DD RT A + T V AER + L+GGCQVP Sbjct: 184 AFSVDTVVPAVGQGAIGLEVRADDERTARACAQVRCAATDACVAAERHVMRALDGGCQVP 243 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGE-------------RRGAPQDAEQMGISLAE 292 IG+YA +G + L A VG+ DGS ++R A ++A + E Sbjct: 244 IGAYARYEEGLLVLDAFVGSLDGSHVLRSRLSAASQPPNDTDAVEAAVREARALAQRAVE 303 Query: 293 ELLNNGAREILAEVYNGD 310 E GAR +L V Sbjct: 304 EFEAQGARAVLDAVRAAG 321 >UniRef50_A8MGE4 Porphobilinogen deaminase n=30 Tax=cellular organisms RepID=HEM3_ALKOO Length = 296 Score = 332 bits (852), Expect = 1e-89, Method: Composition-based stats. Identities = 113/292 (38%), Positives = 160/292 (54%), Gaps = 5/292 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +R+ +R+S LA+ Q+ V + + P + +ELV M T GD+ LD L K+GGKGLF+KE Sbjct: 3 IRVGSRESKLAVKQSEIVIEAIRKYDPNIEIELVTMKTTGDIKLDQTLDKIGGKGLFIKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L+ AL ++R DI VHS KD+P+ + L +V + +REDPRD V ++ + Sbjct: 63 LDQALYDDRVDITVHSFKDMPMAIDEYLPIVAVSKREDPRDVLVLPK--TVKEPDFSKPI 120 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 G SS RR+ QL E P + +RGNV TRL KLD GE+ AI LA+AGLKRLGLE RI Sbjct: 121 GCSSFRRKIQLQEIYPHCSVEPIRGNVLTRLEKLDRGEFSAITLALAGLKRLGLEERISR 180 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 LPA QG + ++ R L+ + E AER+ L GGC P Sbjct: 181 IFEVTEILPAACQGVIVVQARKG--FDVSFLSDFHDKEAWDISMAERSFVRTLNGGCSSP 238 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 + +Y E+ D + L L S + + GA + E+MG +LA ++ Sbjct: 239 VAAYGEIKDNYLTLTGLYVDSSNS-VHKKTITGARKQGEEMGFNLALQMKGE 289 >UniRef50_C7NFP7 Hydroxymethylbilane synthase n=7 Tax=Actinomycetales RepID=C7NFP7_KYTSD Length = 358 Score = 331 bits (850), Expect = 2e-89, Method: Composition-based stats. Identities = 134/327 (40%), Positives = 179/327 (54%), Gaps = 33/327 (10%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 V+R+ TR+S LA Q+ +V D L A G VELV + T GDV PL+++GG G+FV Sbjct: 14 RVVRLGTRRSDLATTQSTHVADALRAR--GHEVELVLVTTEGDVNR-APLSRIGGTGVFV 70 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 L ALL DIAVHS+KD+PV PQ L + + EREDPRDA V+ + +L+ LPAG+ Sbjct: 71 SALRDALLAGEIDIAVHSLKDLPVAQPQELVIAAVPEREDPRDALVARDGLTLETLPAGA 130 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGT S RR+ QL RPDL + LRGNV RL+ + GE DA++LA AGL+RLGL + Sbjct: 131 RVGTGSPRREAQLRVARPDLEVVDLRGNVPRRLATVAEGELDAVVLAGAGLRRLGLTEHV 190 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 L P++ +PA GQGA+ +ECR DD+ + +L L+H T TAERA+ LE GC Sbjct: 191 TQWLEPQVMVPAPGQGALAVECRSDDAESIAMLEPLDHLPTRTATTAERAVLGTLEAGCS 250 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQII------------------------------R 273 PIG+ A + L G DGS+ + Sbjct: 251 APIGALARHDGARVDLMTFAGPRDGSRALLEADCARGVPAGHPADTPDDTPADTPDDSRN 310 Query: 274 GERRGAPQDAEQMGISLAEELLNNGAR 300 +R A ++G +AE L GA Sbjct: 311 DDRVALDTAARELGRRVAEALRGGGAD 337 >UniRef50_B3DZQ6 Porphobilinogen deaminase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DZQ6_METI4 Length = 298 Score = 330 bits (848), Expect = 3e-89, Method: Composition-based stats. Identities = 114/296 (38%), Positives = 164/296 (55%), Gaps = 3/296 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L I +R S LAL QA + D L +P L +++ + T GD + P+ + +G+F Sbjct: 2 KPLIIGSRGSRLALIQAQLIVDSLKKEYPLLDIQIRVIKTTGDHLEAQPIRDIDQRGIFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE+E LLE D+AVHS+KD+ VE L + I REDPRD ++S + +L AG+ Sbjct: 62 KEIENKLLEGEIDLAVHSLKDLQVELHPRLVIAAIPPREDPRDCWISLQHPHPSSLQAGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG-EYDAIILAVAGLKRLGLE-- 180 IV T S RR QL +RPDL I +RGNV +RL KL ++ +LA+AG+KRLG++ Sbjct: 122 IVVTGSPRRANQLLRKRPDLRIVPVRGNVESRLRKLRENRQWQGTVLALAGIKRLGIDIS 181 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 S L + LPA GQGA+ ++ R++D T+ L+ LN TA VTAER L G Sbjct: 182 SFFCTPLSMDWMLPAPGQGALALQARIEDKHTQSLVKHLNDFSTACAVTAERVFLHELGG 241 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 GC+ +G+ AE+ + L + + G+ G AE +G LA+ L N Sbjct: 242 GCRTAVGARAEVEGSRLVLEGIWWPQQAIEPKEGKVVGEIHRAEDLGKKLADLLKN 297 >UniRef50_Q09899 Porphobilinogen deaminase n=2 Tax=Schizosaccharomyces RepID=HEM3_SCHPO Length = 336 Score = 330 bits (847), Expect = 4e-89, Method: Composition-based stats. Identities = 126/314 (40%), Positives = 178/314 (56%), Gaps = 16/314 (5%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG---GKGLFVK 64 I TR+S LA+ Q+ ++++L +P L ++ T GD IL L + K L+ + Sbjct: 9 IGTRKSKLAVIQSEIIREELEKHYPHLEFPIISRDTIGDEILSKALFEFKRQLAKSLWTR 68 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALPA 121 ELE L+ N+ I VHS+KD+P E P G+ + I +R P DA V +Y ++ LP Sbjct: 69 ELEALLVTNQCRILVHSLKDLPSEMPDGMVIACIPKRSCPLDAIVFKAGSHYKTVADLPP 128 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLKRLGL 179 GS+VGTSS+RR+ LA P L +RGNVGTRL+KLD + ++D ++LA AGL RLGL Sbjct: 129 GSVVGTSSIRRRALLARNFPHLRFVDIRGNVGTRLAKLDAPDSQFDCLVLAAAGLFRLGL 188 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 + RI L AVGQGA+ +E R DD E+L L H ET AERA+ RL+ Sbjct: 189 KDRIAQMLTAPFVYYAVGQGALAVEVRADDKEMIEMLKPLQHQETLYACLAERALMKRLQ 248 Query: 240 GGCQVPIGSYAELI-----DGEIWLRALVGAPDGSQIIRGE---RRGAPQDAEQMGISLA 291 GGC +PIG +++ I L V + DG + G + ++AE++GI++A Sbjct: 249 GGCAIPIGVQTDVLAISNSSYRISLLGTVLSADGLRAAFGNAEAVVSSEEEAEELGITVA 308 Query: 292 EELLNNGAREILAE 305 LL NGA IL E Sbjct: 309 LALLKNGAGPILEE 322 >UniRef50_Q0BX92 Porphobilinogen deaminase n=1 Tax=Hyphomonas neptunium ATCC 15444 RepID=HEM3_HYPNA Length = 321 Score = 329 bits (844), Expect = 9e-89, Method: Composition-based stats. Identities = 120/298 (40%), Positives = 166/298 (55%), Gaps = 7/298 (2%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPG-LVVELVPMVTRGDVILDTPLAKVGGKGLF 62 LR+ TR SPLAL QAH + D + A+ G E+V T GD + L GGKGLF Sbjct: 11 KRLRLGTRGSPLALAQAHQIADGIRAASAGAYDCEIVAFTTTGDKLTTERLINSGGKGLF 70 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 +EL+ AL D+AVHS+KDVP P G +REDPRD F+S+ S+ LP G Sbjct: 71 TRELDDALSRGELDLAVHSLKDVPSVLPPGQIFAAFPKREDPRDGFLSHGAKSIQDLPEG 130 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 + +GT+SLRR+ Q RPDL + + RGNV TR+ KL+ G DA LA+AGL RLGL Sbjct: 131 ATLGTASLRREAQALALRPDLKVVTFRGNVATRMRKLEEGLADATFLAMAGLTRLGLSEV 190 Query: 183 IRAALPPEISLPAVGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 +P E LPA GQG +G+ R D D+ E+L L+H + + AERA +L+G Sbjct: 191 AT-PIPLEDMLPAAGQGIIGVVTRDDVDTELLEILGQLSHEPSRVAAIAERAFLEKLDGS 249 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQ----MGISLAEELL 295 C+ PI ++ E L V +P G+ RG+ + +G ++A+E++ Sbjct: 250 CRTPIAAHLFDRGDEWQLIGEVLSPGGTTRWRGDGVCRKDATDAQLVLLGRAVAQEII 307 >UniRef50_A0DD68 Chromosome undetermined scaffold_46, whole genome shotgun sequence n=2 Tax=Paramecium tetraurelia RepID=A0DD68_PARTE Length = 306 Score = 328 bits (843), Expect = 1e-88, Method: Composition-based stats. Identities = 125/312 (40%), Positives = 172/312 (55%), Gaps = 13/312 (4%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTR-GDVILDTPLAKVGGKG 60 + LRIATR S LA+ Q +YV +L E++ + GDV L PL ++ G Sbjct: 1 MQRQLRIATRSSALAMAQTNYVISELKQ-----ECEIIKVSNEVGDVNLQDPLYQMPTVG 55 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLD 117 +F K++E LLE +AD+AVHS+KD+P L L + E D + N Y SL Sbjct: 56 VFTKQVEQYLLEQKADVAVHSLKDLPTIIDAQLHLAAYTKFEQRGDVVLLNKKYNYKSLS 115 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177 LP G VGTSSLRR + R P L + ++RGN+ TR+ KLD G+YDAIILA AG+ RL Sbjct: 116 ELPDGLKVGTSSLRRIATIRSRYPKLNLINIRGNLNTRIQKLDEGQYDAIILAKAGILRL 175 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 GL +I L + L A Q A+GI+CR DD T L LN + R AER Sbjct: 176 GLAEKISFDLDEKEFLYAPAQAALGIQCRKDDLETIGRLQILNDTDAQKRCVAERMFLNL 235 Query: 238 LEGGCQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 LEGGC++PI Y+E DG+++++ V A DGS++I E A E +G L E++ Sbjct: 236 LEGGCRLPIAVYSECREDGQVYIKGRVLAVDGSKVIEDE---ALDHFEIVGQILCEKIKV 292 Query: 297 NGAREILAEVYN 308 G E++ + Sbjct: 293 LGGVELIESLKQ 304 >UniRef50_A4XK06 Porphobilinogen deaminase n=2 Tax=Clostridia RepID=HEM3_CALS8 Length = 290 Score = 328 bits (841), Expect = 2e-88, Method: Composition-based stats. Identities = 103/293 (35%), Positives = 155/293 (52%), Gaps = 4/293 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 LRI R S L+ Q V K+ + G+ E VP+ T+GD+ L G+FV Sbjct: 2 KKLRIGARDSKLSRIQVDIVARKIKQT-LGIECEFVPIKTKGDIDKTKSLKDFKSPGVFV 60 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE+E+ALL D+AVHS+KD+P E +V + EREDPRD VS + L + Sbjct: 61 KEIELALLSREIDLAVHSLKDLPCEMDSNFEIVAVVEREDPRDVLVSKDGVGFYQLKPNA 120 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +GTSSLRR+ L R D+ + ++RGN+ TRLSK+++ D ++LA A LKRL L+S + Sbjct: 121 KIGTSSLRREVHLKNLRQDIQVVNIRGNIETRLSKIESEGLDGVVLAYAALKRLNLDSHV 180 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 P GQGA+ IEC L DS + +L+ +N + ++ ER + L GGC Sbjct: 181 SYIFDVNEITPCPGQGAICIEC-LKDSPYKNILSKINDADAYIQTQFERLVLKFLGGGCH 239 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 IG + + +I+ A + + G ++I+ G D + L+ L + Sbjct: 240 SSIGVFCKTDQDKIYAFASILS--GDKLIKASIEGDKDDFLSLANKLSNMLKS 290 >UniRef50_C4QMG7 Hydroxymethylbilane synthase (Porphobilinogen deaminase, putative) n=1 Tax=Schistosoma mansoni RepID=C4QMG7_SCHMA Length = 411 Score = 327 bits (839), Expect = 4e-88, Method: Composition-based stats. Identities = 117/302 (38%), Positives = 161/302 (53%), Gaps = 25/302 (8%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 NV+R+ +R+S LAL Q + L +P ++ E+V M T GD ILD L+K+G K LF Sbjct: 8 NVVRVGSRRSNLALLQTGMAVNLLQKQNPHILFEVVEMATVGDKILDVSLSKIGDKSLFT 67 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDSLDALP 120 KELE ALL D+ VHS+KDVP P GL L + R P D + L LP Sbjct: 68 KELENALLSGEVDLVVHSLKDVPSTLPSGLVLGCVFARVSPEDVVLMAPHYRGRKLSDLP 127 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--------------NGEYDA 166 GS VGTS++RR L + P L S+RGN+ TRL+KLD + YDA Sbjct: 128 IGSTVGTSAVRRVATLTRKYPHLKFVSIRGNLNTRLAKLDTPPASKDNCCSGNPSPSYDA 187 Query: 167 IILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETAL 226 IILA AG++R+G RI L AV QGA+ ECRL D+ +LL+ ++ AL Sbjct: 188 IILAKAGVERMGWSHRIDQVLTDSF--YAVSQGALACECRLVDNFIMDLLSHIHDESAAL 245 Query: 227 RVTAERAMNTRLEGGCQVPIGSYAELI--DG----EIWLRALVGAPDGSQIIRGERRGAP 280 AER++ +L+GGC +PIG ++L+ ++ L A + + DG + I Sbjct: 246 TTIAERSLMRQLDGGCSIPIGVRSDLVLKGDLNYYQLTLHANILSVDGGKSIERSASVVF 305 Query: 281 QD 282 D Sbjct: 306 PD 307 >UniRef50_Q8D2W2 HemC protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis RepID=Q8D2W2_WIGBR Length = 291 Score = 327 bits (838), Expect = 5e-88, Method: Composition-based stats. Identities = 132/289 (45%), Positives = 193/289 (66%), Gaps = 1/289 (0%) Query: 20 AHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAV 79 + K KL+ HP L ++LVP++T GD+I KGLF+KELE +LL+ ++DIAV Sbjct: 3 SKLCKKKLLHYHPKLNIKLVPILTTGDLINKIRNNITNEKGLFIKELEKSLLKYQSDIAV 62 Query: 80 HSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAER 139 HSMKD F LGL IC+R+DPRDA VSN Y+++ +LP + VGTSSLRR+CQL Sbjct: 63 HSMKDFSSSFLDSLGLAAICKRDDPRDAIVSNYYNNIISLPNNAKVGTSSLRRKCQLLSI 122 Query: 140 RPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQG 199 RPDL I +GN+ +RL KL+ G +DA+ILA A LKRL + ++ + P LPA+GQG Sbjct: 123 RPDLKIFPCKGNIHSRLKKLNQGVFDALILATAALKRLKINEQMYTPIDPSYLLPAMGQG 182 Query: 200 AVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID-GEIW 258 ++ I+CRL D++ +++ +N+ +TAL + +E+ + + L GC+VPIGSYA++ + IW Sbjct: 183 SIAIQCRLYDNKIIDIVRNINNKKTALCINSEKIVVSMLGTGCRVPIGSYAKIENKNTIW 242 Query: 259 LRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVY 307 +RALVG+ DGS IIR E + +AE++ + L+N GA+ IL + Sbjct: 243 IRALVGSIDGSNIIRSEGKSCVSNAEKLSKKQVKNLINLGAKNILKKFK 291 >UniRef50_Q7UPN0 Porphobilinogen deaminase n=1 Tax=Rhodopirellula baltica RepID=HEM3_RHOBA Length = 337 Score = 326 bits (837), Expect = 5e-88, Method: Composition-based stats. Identities = 128/329 (38%), Positives = 183/329 (55%), Gaps = 27/329 (8%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LRIATR+SPLA+WQA +V L G E+VP+V++GD + P+ GLF K Sbjct: 12 LRIATRESPLAMWQAEHVAKLLKKH--GFQTEIVPLVSKGDTDM-RPIDGTRQVGLFTKR 68 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS---------- 115 ++ AL+++ AD+AVHS+KD+P E L + RE DA V + Sbjct: 69 IQQALVDDEADVAVHSLKDLPTEPDSRFVLAAVPPRESVLDALVFADNSPHLESQTGAES 128 Query: 116 -LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174 LD LP G+ VGT S RR QL + RPDL + +RGNV TRL+KL+ GE+DAI+LA AG+ Sbjct: 129 PLDYLPQGARVGTGSTRRLAQLKQLRPDLEVLPIRGNVQTRLAKLNAGEFDAIVLAHAGI 188 Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234 RL + P + +PA GQGA+GIE R DD+ + +A LN L TAER + Sbjct: 189 LRLEMTDLPHRLFPLDEMIPAPGQGALGIEVRSDDAGAMDAIANLNDAAARLAATAERKV 248 Query: 235 NTRLEGGCQVPIGSYAELI----DGEIWLRALVGAPDGSQIIRGERRGAPQ--------- 281 + L GGC PI +A+L E+ LRA+V + DG Q ++ + R Q Sbjct: 249 LSELHGGCLAPIACHAKLETSNHGTELCLRAIVMSADGEQRLQEDARITVQPNDADLHVA 308 Query: 282 DAEQMGISLAEELLNNGAREILAEVYNGD 310 +A ++G +A+ L + GA ++++ V Sbjct: 309 EAHELGTLVAKRLRDKGADKLISTVRENH 337 >UniRef50_A4CHM3 Porphobilinogen deaminase n=4 Tax=Bacteroidetes RepID=A4CHM3_9FLAO Length = 315 Score = 325 bits (833), Expect = 2e-87, Method: Composition-based stats. Identities = 123/318 (38%), Positives = 168/318 (52%), Gaps = 18/318 (5%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + LRI TR S LALWQA V+D+L A+ G ELVP+ + GD++LD PL ++G G+ Sbjct: 1 MSRALRIGTRDSELALWQAQTVRDRLEAA--GHRAELVPVKSTGDLVLDKPLYELGITGI 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F K L+VALL D+AVHSMKDVP P+G+ + ER RD V LD Sbjct: 59 FTKTLDVALLREDIDLAVHSMKDVPTALPEGICQAAVLERASARDVLVHKGLGFLDG--P 116 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G + T SLRR+ Q R P + LRGNV TRL L +D I A AGL+R+GL Sbjct: 117 G-TIATGSLRRKAQWLNRYPAHQVTGLRGNVNTRLKLLRENSWDGAIFAQAGLERIGLLP 175 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 P + LPA QGA+ + R D+ RE L+H ++AL V ER LEGG Sbjct: 176 DNAE--PLDWMLPAPAQGAMLVVARTSDTAAREAARPLHHEQSALEVAVEREFLRTLEGG 233 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER-RGAPQ----------DAEQMGISL 290 C PIG+ DG++ L + + DG + R R G+ + DA + G + Sbjct: 234 CSAPIGARVHAADGQLHLEGGLFSLDGKKAFRVTRHTGSLEAGGTGDARFQDAGEFGAAC 293 Query: 291 AEELLNNGAREILAEVYN 308 A E+L++G ++ + Sbjct: 294 AREILDSGGAVLMESIRK 311 >UniRef50_Q4T5L1 Chromosome undetermined SCAF9206, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4T5L1_TETNG Length = 385 Score = 325 bits (833), Expect = 2e-87, Method: Composition-based stats. Identities = 135/376 (35%), Positives = 190/376 (50%), Gaps = 85/376 (22%) Query: 13 SPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLE 72 S LA Q V +KL +P + +E+V M T GD ILDT L+K+G K LF KELE AL Sbjct: 1 SQLARIQTDSVAEKLKELYPDVHLEIVAMSTTGDKILDTALSKIGEKSLFTKELENALER 60 Query: 73 NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALPAGSIVGTSS 129 N D+ VHS+KD+P P G + + +RE+P DA V + +LDALPA S++GTSS Sbjct: 61 NEVDLVVHSLKDLPTSLPPGFTIGAVLKRENPHDAVVLHPKNAGKTLDALPAHSVIGTSS 120 Query: 130 LRRQCQLAERRPDLIIRSL------------------------RGNVGTRLSKLDNGE-Y 164 LRR QL +R P L + + RGN+ TRL KLD E + Sbjct: 121 LRRAAQLKKRFPHLDFKDIVSSERCFLPVQPGHRCFFLSSRSQRGNLNTRLKKLDEKEDF 180 Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224 AIILA AGL+R+G ++RI L PE + AVGQGA+ +E R D+ E+++ L+ +T Sbjct: 181 AAIILAAAGLRRMGWDNRISQILEPEDCMYAVGQGALAVEVRAKDADILEMVSVLHDPDT 240 Query: 225 ALRVTAERAMNTRL----------------------------EGGCQVPIGSYAELIDGE 256 LR AERA L EGGC VP+ + ++ D + Sbjct: 241 VLRCIAERAFLKHLVQHTHTHTHTHTHTRSLAVAHWNLFCLQEGGCSVPVAVHTKVKDSQ 300 Query: 257 IWLRALVGAPDGSQIIRGERR--------GAPQD---------------------AEQMG 287 ++L V + DGS ++ + G+P + AE++G Sbjct: 301 LYLTGAVYSLDGSDSLKETMQTSVAAPADGSPDEVDECARVGVTANKIPGEAQDRAERLG 360 Query: 288 ISLAEELLNNGAREIL 303 + LA+ LL+ GA+EIL Sbjct: 361 VDLAKLLLSKGAKEIL 376 >UniRef50_Q47LA7 Porphobilinogen deaminase n=3 Tax=Actinomycetales RepID=HEM3_THEFY Length = 320 Score = 324 bits (832), Expect = 2e-87, Method: Composition-based stats. Identities = 127/318 (39%), Positives = 177/318 (55%), Gaps = 11/318 (3%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M R+ TR+S +A Q+ V + L A G+ VELV + + GD I L ++GG G Sbjct: 1 MSTTPARLGTRRSTMATNQSRRVAEILTAR-TGVPVELVLITSFGD-ITRAHLTQLGGTG 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 +FV L ALL + AVHS+KD+P +G+ L + ER+DPRDA + + LP Sbjct: 59 VFVSALRDALLAGEVEFAVHSLKDLPTAPTEGIVLAAVTERDDPRDALCARDGLKFADLP 118 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGT S RR QLA RPDL +RGN TRL K+ +GE DA++LA AGL R+G Sbjct: 119 PGATVGTGSPRRVAQLAALRPDLRYVPIRGNAETRLGKVASGELDAVVLAYAGLHRVGRL 178 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDD-SRTRELLAALNHHETALRVTAERAMNTRLE 239 + + LPA GQGA+ +ECR D + L A++H T VTAER + LE Sbjct: 179 DDVTDVFDVDQVLPAPGQGALAVECRTADFTGPLRYLTAVDHLPTRAAVTAERVILAELE 238 Query: 240 GGCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQD-------AEQMGISLA 291 GC P+G+YAE + + + LRA V A DGSQ +R E+ + A +G LA Sbjct: 239 AGCAAPVGAYAEFVAEDRLRLRAAVVATDGSQAVRAEQTVTVTEFPDAVQAATALGRQLA 298 Query: 292 EELLNNGAREILAEVYNG 309 +++ GA +I+A+ G Sbjct: 299 HDMIEQGADQIVADAAAG 316 >UniRef50_C6XKH7 Porphobilinogen deaminase n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XKH7_HIRBI Length = 323 Score = 324 bits (831), Expect = 3e-87, Method: Composition-based stats. Identities = 110/299 (36%), Positives = 153/299 (51%), Gaps = 7/299 (2%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPG-LVVELVPMVTRGDVILDTPLAKVGGKG 60 +++I R SPLA+ QA + + +E+ T GD +LD L GGKG Sbjct: 17 STQIVKIGARGSPLAVQQAEDFAARFKEIVGNTVEIEIHTFTTSGDQLLDKRLQDAGGKG 76 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF +EL++A L R DI VHS+KDVP P GL + REDPRDA ++ LP Sbjct: 77 LFTRELDIAQLSGRIDIVVHSLKDVPTVLPDGLQMGCYLPREDPRDALFGKVG-NIKDLP 135 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GT+SLRR Q RPDL I RGNV TRL KL+ G+ DA +LA AGL RLG+ Sbjct: 136 HGATLGTASLRRSAQALALRPDLKIVMFRGNVQTRLRKLEEGQADATLLAAAGLNRLGMT 195 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLE 239 + +P E LPA GQG V + + + ++ E+ + AERA RL+ Sbjct: 196 DKAAGFMPKEEMLPACGQGIVCTTLTNNAEDWIFKACLQIDVLESRIAAIAERAFLKRLD 255 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRG----APQDAEQMGISLAEEL 294 G C+ PI + + + +R V A DGS+ + A +G L E++ Sbjct: 256 GSCRTPIAGHLSFNETGVDMRGEVLADDGSKRWFSQMSLDTIPDENQAASLGFELGEKV 314 >UniRef50_Q9F7M2 Predicted porphobilinogen deaminase n=2 Tax=Bacteria RepID=Q9F7M2_PRB01 Length = 303 Score = 323 bits (830), Expect = 4e-87, Method: Composition-based stats. Identities = 110/298 (36%), Positives = 170/298 (57%), Gaps = 2/298 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RIATRQS LA++QA +V D+L+A + VELVPM + GD D PL ++GGKGLF+ Sbjct: 3 IRIATRQSELAMYQAKFVADELLAKINNIKVELVPMTSEGDQ-TDKPLHEIGGKGLFIST 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE +L + ADIAVHS+KDVP + ++++ RE P D +S + S S + Sbjct: 62 LESSLEADEADIAVHSLKDVPAKLDPKFKIISVFSRESPEDLLLSKDGKSFSEFARNSTI 121 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTS RR+ Q+ RPD+ +RGN+ TR+ KL++G +D +++A A +KRLGL+ Sbjct: 122 GTSGPRRKAQINNLRPDIKTIPVRGNIATRIKKLNDGLFDGLVVAKAAIKRLGLKQNSYE 181 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 E LP+ QG + IEC D ELL + + + +AER+ +EG C P Sbjct: 182 F-SIEEMLPSASQGYIAIECLSDKKDIIELLENIGDPKELILASAERSFVAAMEGTCLSP 240 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 I E +G+I + + + +G++ I E+ + QD + A+E + GA+ ++ Sbjct: 241 IAILCEDKNGQIKISGKILSYEGNEKIYKEKISSFQDIAIDIMLFADEFILEGAKSLI 298 >UniRef50_A3MLK5 Porphobilinogen deaminase n=155 Tax=Proteobacteria RepID=HEM3_BURM7 Length = 329 Score = 323 bits (829), Expect = 4e-87, Method: Composition-based stats. Identities = 162/315 (51%), Positives = 208/315 (66%), Gaps = 3/315 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 L L IA+R+S LA+WQA +V+D L +P V+++ M TRGD ILD L+KVGGKGL Sbjct: 10 LPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGL 69 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKELE AL + RAD+AVHS+KDVP+ P+G L + REDPRDAFVSN+Y SLDALPA Sbjct: 70 FVKELESALADGRADLAVHSLKDVPMALPEGFALAAVMSREDPRDAFVSNDYASLDALPA 129 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G++VGTSSLRR+ L R P L +R LRGN+ TRL+KLD G+Y AIILA AGLKRLGL + Sbjct: 130 GAVVGTSSLRREAMLRARHPRLDVRPLRGNLDTRLAKLDRGDYAAIILAAAGLKRLGLAA 189 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 RIRA L + SLPA GQGA+GIE + LA L+ H +AL V AERA++ L G Sbjct: 190 RIRALLDVDDSLPAAGQGALGIEIAARRADVAAWLAPLHDHASALAVEAERAVSRALGGS 249 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQI---IRGERRGAPQDAEQMGISLAEELLNNG 298 C+VP+ ++A GE+ L V DG+++ R DA +G +++ L G Sbjct: 250 CEVPLAAHAVWRGGELHLTGSVSTTDGARVLAAHAHARAATAADALALGRRVSDALERQG 309 Query: 299 AREILAEVYNGDAPA 313 AR I+ + A A Sbjct: 310 ARAIVDALVAASAQA 324 >UniRef50_B2IAW6 Porphobilinogen deaminase n=4 Tax=Alphaproteobacteria RepID=B2IAW6_BEII9 Length = 337 Score = 323 bits (829), Expect = 5e-87, Method: Composition-based stats. Identities = 138/306 (45%), Positives = 179/306 (58%), Gaps = 5/306 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 LR+ TR SPLAL QAH + D+L +H V + + T GD+I D PL+ GGKGLF Sbjct: 19 LRLGTRGSPLALAQAHELADRLARAHGFAKEAVAITIIRTSGDMIQDRPLSLAGGKGLFT 78 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KEL+ AL+E D+AVHS KD+P P+ L + RED RD ++S LP GS Sbjct: 79 KELDQALIEGMVDLAVHSAKDLPTILPEDLIIAGYLPREDVRDVWISPKAGHPRDLPPGS 138 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +VGT+SLRR L RPDL +R LRGNV TRL+KL GE DA +LA+AGL+RLGL + Sbjct: 139 VVGTASLRRGALLKRLRPDLEVRLLRGNVETRLAKLAAGEVDATLLALAGLRRLGLADKA 198 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 L E LPA GQGA+GI R DD+ T LLA + T + + AER T L+G C+ Sbjct: 199 TQVLAIEDFLPAAGQGAIGITTRRDDAATLALLAPILDPATHVALAAERGFLTVLDGSCK 258 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 PIG++A + ++ LR +V PDGS+ G + + A EL AR IL Sbjct: 259 TPIGAHATVEHDQVTLRGIVLRPDGSEWFEACESGPLESGS---LEAARELGETAARAIL 315 Query: 304 AEVYNG 309 A + G Sbjct: 316 ARLPEG 321 >UniRef50_C2GGB5 Porphobilinogen deaminase n=2 Tax=Corynebacterium glucuronolyticum RepID=C2GGB5_9CORY Length = 290 Score = 323 bits (829), Expect = 5e-87, Method: Composition-based stats. Identities = 121/299 (40%), Positives = 165/299 (55%), Gaps = 11/299 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR S LA QA +V+D L+ + G EL + T GD L +P+ K+G G+F + Sbjct: 2 TLRIGTRGSKLATTQAGHVRDALIRA--GYDAELTIITTPGDKNL-SPVQKIG-VGVFTQ 57 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L A+ + DIAVHS KD+P P+GL + RE P +A ++ + +LD LP G+ Sbjct: 58 ALREAMDRDEIDIAVHSCKDLPTGQPEGLATI-YPVRETPCEALIARDGLTLDQLPEGAK 116 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGT + RR QL RPDL IR LRGNV TR+ K+ +GE DA+ILA AGL R+G Sbjct: 117 VGTGAPRRISQLKALRPDLDIRPLRGNVDTRMGKVTSGELDAVILAHAGLTRIGRGDEAT 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 P +PA QG + +E R L ++ H T L AERA+ + L+ GC Sbjct: 177 QVFDPTYLMPAPAQGILAVESRTHVDAISTL---IDDHAT-LSAQAERAVLSTLQAGCTA 232 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 P+ +Y+ + EI L A A DGS+ I G D +G S+AE+L GA EI+ Sbjct: 233 PLAAYSTVSGDEITLTAGAFALDGSKQIVETATGT--DPVALGTSVAEKLRACGAEEII 289 >UniRef50_B8GXG1 Porphobilinogen deaminase n=8 Tax=Caulobacteraceae RepID=HEM3_CAUCN Length = 322 Score = 323 bits (828), Expect = 6e-87, Method: Composition-based stats. Identities = 133/315 (42%), Positives = 177/315 (56%), Gaps = 17/315 (5%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMAS----------HPGLVVELVPMVTRGDVILDTPLA 54 +RI R S L+L Q+ ++ ++ + L+P+VT GD I D L Sbjct: 6 PIRIGARGSKLSLAQSGLMQARIAHALGVPAGASKDEIEAAAPLIPIVTSGDRIQDRRLM 65 Query: 55 KVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD 114 ++GGKGLF KE+E ALL+ R D AVHS+KD+P E P GL L EREDPRDAF+S+ + Sbjct: 66 EIGGKGLFTKEIEEALLDGRIDCAVHSLKDMPAELPPGLVLAATPEREDPRDAFISHVCE 125 Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174 L+ LP G+ +GT+SLRRQ Q RPDL I LRGNV TRL+KL+ GE DAI+LA +GL Sbjct: 126 RLEDLPKGARLGTASLRRQAQALHVRPDLEIVMLRGNVDTRLAKLERGEADAILLAQSGL 185 Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234 RLGL R+ L P+ PA GQGA+ IE R +D L A+ +T + V AER Sbjct: 186 NRLGLGHLTRSWLDPDACPPAPGQGALVIETRAEDIG-APWLEAVRCRQTTIAVAAERGA 244 Query: 235 NTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE----RRG--APQDAEQMGI 288 LEG C+ IG+ A L + + PDG+Q R E G +A G+ Sbjct: 245 LLALEGSCRTAIGARAILDGARLSMIVEALTPDGAQRFRREGDITLTGADDIAEARAFGL 304 Query: 289 SLAEELLNNGAREIL 303 +L E+ G I+ Sbjct: 305 TLGAEVRAAGGDAII 319 >UniRef50_A8SQW4 Putative uncharacterized protein n=1 Tax=Coprococcus eutactus ATCC 27759 RepID=A8SQW4_9FIRM Length = 350 Score = 323 bits (828), Expect = 6e-87, Method: Composition-based stats. Identities = 115/314 (36%), Positives = 165/314 (52%), Gaps = 26/314 (8%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 +++ TR S LAL Q V L P + ++V M TRGD L + GGK +F Sbjct: 39 KKTVKVGTRGSKLALAQTELVIKALNERFPQIDFQMVTMSTRGDRDTSRALLEFGGKAVF 98 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 V+E E A+L+ DIAVHS KD+P+E +GL + R P+D F+ + S D + Sbjct: 99 VEEFEEAILKGDIDIAVHSAKDMPMEIMEGLTISGTLPRACPQDVFIYKSGRSFDRNDSF 158 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL--- 179 +VGTSSLRRQ Q+ + P+ + ++LRGNVGTR+ KL++GEYDAIILA AGL+RLG+ Sbjct: 159 -VVGTSSLRRQYQIRDMYPNAVCKNLRGNVGTRIQKLEDGEYDAIILAAAGLERLGVIED 217 Query: 180 -------------ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETAL 226 + L E LPA QG + IE R +++ A+N E Sbjct: 218 KGNDSTECFEVHKDELTFRYLSTESMLPAACQGIIAIETRTSGEAY-DMVRAINDTEAYT 276 Query: 227 RVTAERAMNTRLEGGCQVPIGSYAELIDGEIWL---RALVGAPDGSQ-----IIRGERRG 278 ++T ERA+ +RL GC PIG Y+EL + L + + D + I R G Sbjct: 277 QLTCERAVLSRLNAGCHEPIGVYSELKGKHMKLSLMKVDAASSDKEKDEEIQIHRKTVEG 336 Query: 279 APQDAEQMGISLAE 292 + EQ+ +L + Sbjct: 337 NTSEWEQLVEALIK 350 >UniRef50_C6XST0 Porphobilinogen deaminase n=2 Tax=Pedobacter RepID=C6XST0_PEDHD Length = 526 Score = 323 bits (828), Expect = 7e-87, Method: Composition-based stats. Identities = 114/259 (44%), Positives = 155/259 (59%), Gaps = 8/259 (3%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L I TR S LALWQA+++KDKL A G+ EL + T+GD IL+ L K+ GKG F Sbjct: 2 KRLIIGTRGSDLALWQANFIKDKLAAI--GVEAELKIIKTQGDKILNLRLDKLEGKGFFT 59 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRD-AFVSNNYDSLD---AL 119 KELE LL DIAVHS KD+P P GL + + EREDP + + + S++ +L Sbjct: 60 KELEEELLGGTIDIAVHSHKDLPTVHPAGLTIAAVTEREDPSELLLILKDCVSINHKLSL 119 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG- 178 G++VGTSS RR+ QL RPDL I LRGNV TR+ KL + +YDAI+LA AG+ RL Sbjct: 120 KKGAMVGTSSNRRKAQLLALRPDLNIEDLRGNVPTRIQKLRDEDYDAILLARAGVNRLNI 179 Query: 179 -LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 L + +PA QGA+ I+ R +++ ++L +NH ETA + ER + Sbjct: 180 DLSEFHVEVVDTTELVPAPAQGALAIQIRENENELFDILQQINHSETAEEIAIERKVLNL 239 Query: 238 LEGGCQVPIGSYAELIDGE 256 EGGC +P+G Y + DG+ Sbjct: 240 FEGGCHMPLGCYCKKEDGQ 258 >UniRef50_O29026 Probable porphobilinogen deaminase n=1 Tax=Archaeoglobus fulgidus RepID=HEM3_ARCFU Length = 289 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 114/294 (38%), Positives = 167/294 (56%), Gaps = 15/294 (5%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L + TR S LAL Q + V ++L + VE+ + T GD++ D PL + G G FV+ Sbjct: 3 LIVGTRGSKLALAQTNKVAERLKERY---EVEIRIVKTAGDIMKDKPLYEFKGMGAFVRA 59 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L+ AL E + D+AVHS KDVP + +G + + ER+ P D +S + +L+ L G++V Sbjct: 60 LDTALAEGKVDVAVHSFKDVPSQRVEGTVVAAVIERDSPCDVLISRDGSTLEELDEGAVV 119 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI-R 184 GTSSLRR+ QL+ R DL +LRGN+ TRL KL G YDAI++A AGLKRLGL+ + Sbjct: 120 GTSSLRRRAQLSRLRGDLRFENLRGNLDTRLRKLREGNYDAIVVAEAGLKRLGLDREVEY 179 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 PPE+ +P QG + I R + +L+A LN +T L ERA+ L GC V Sbjct: 180 QPFPPEVIVPPANQGIIAIATRKGEE---DLVAFLNDEKTWLEAMVERAVIKELGVGCAV 236 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERR----GAPQDAEQMGISLAEEL 294 P+G YAE + L + + +R E + A ++A ++G L +E+ Sbjct: 237 PVGVYAE-AQSRVRLICEILD---KKYLRVEEKLSKDTAVEEAAEIGKDLRKEI 286 >UniRef50_D1BFI8 Hydroxymethylbilane synthase n=4 Tax=Actinomycetales RepID=D1BFI8_SANKS Length = 312 Score = 322 bits (825), Expect = 1e-86, Method: Composition-based stats. Identities = 127/310 (40%), Positives = 172/310 (55%), Gaps = 14/310 (4%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR S LAL Q V D L G VE+VP+ T GD +L L+++GG G+FV Sbjct: 6 ALRIGTRSSLLALTQTGTVADDLRRL-TGRPVEIVPVTTDGD-VLTGSLSQMGGTGVFVT 63 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L ALL++R D+AVHS+KD+P GL V R+DPRDA S L LP G+ Sbjct: 64 ALRAALLDDRCDVAVHSLKDLPTAGVLGLQHV-TPVRQDPRDALCSRAGHRLADLPHGAR 122 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--DNGEYDAIILAVAGLKRLGLESR 182 VGT S RR QL RPDL + +RGN+ TRL ++ + G+ DA++LA AGL R+G E Sbjct: 123 VGTGSPRRAAQLRLVRPDLDVVDIRGNIDTRLGRVHPETGDLDAVVLAAAGLNRIGREHA 182 Query: 183 IRAALPPEISLPAVGQGAVGIECR----LDDSRTRELLAALNHHETALRVTAERAMNTRL 238 I + PA GQGA+ +E R +D L+ T+L V AERA+ RL Sbjct: 183 ITELISVTDMAPAPGQGALAVETRSSLLEEDPVVARAFDQLDDPATSLSVLAERALLARL 242 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD-----AEQMGISLAEE 293 E GC P+G++A + DG + L A+V PDGS+ +R + D A +G ++A+ Sbjct: 243 EAGCAAPVGTHATVSDGLLTLHAVVARPDGSEQLRHNQSTEVADTSTAEAVALGEAVADH 302 Query: 294 LLNNGAREIL 303 L GA + Sbjct: 303 FLALGAASFI 312 >UniRef50_Q46CH0 Probable porphobilinogen deaminase n=7 Tax=Euryarchaeota RepID=HEM3_METBF Length = 316 Score = 322 bits (825), Expect = 1e-86, Method: Composition-based stats. Identities = 113/303 (37%), Positives = 163/303 (53%), Gaps = 7/303 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG-GKGLFVK 64 + I TR S LAL QA V L A G+ L + T GD D PL V G G FV+ Sbjct: 1 MIIGTRGSQLALAQAETVARLLKAK--GVETSLKIIKTSGDRFTDRPLHAVSSGVGAFVR 58 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 EL+ +LE + DIAVHSMKD+P P L V + +R+ P D ++ + LD L SI Sbjct: 59 ELDEVMLEGKIDIAVHSMKDMPTIRPPTLPTVAVLKRDTPFDLLLTYDGTPLDELSEQSI 118 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSSLRR Q+ RPDL+ + LRGN+ TRL KL G+YD I+LA AGL+R+G E Sbjct: 119 IGTSSLRRAAQIKRYRPDLVTQDLRGNIDTRLRKLKEGKYDGILLAKAGLERMGWELE-G 177 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L P+ P+ QG + + R + + ++ L+H ++ + ER + + L GGC Sbjct: 178 EILSPDFFCPSPNQGTIAVVTRAE-TEAEAAVSRLDHTDSRIATEIERILISELGGGCTT 236 Query: 245 PIGSYAELIDGE--IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 PIGSYAE++ + +RA V + DG + + + L L++ G +++ Sbjct: 237 PIGSYAEIMPDRKKLHVRAEVLSLDGEETVGINEFIPMAGGIEKARELGSSLVHMGGKKL 296 Query: 303 LAE 305 E Sbjct: 297 ADE 299 >UniRef50_B3RTQ8 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RTQ8_TRIAD Length = 314 Score = 322 bits (825), Expect = 2e-86, Method: Composition-based stats. Identities = 120/338 (35%), Positives = 172/338 (50%), Gaps = 64/338 (18%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M + V+RI TR+S LA+ Q H V D L HP +E+V M T GD +LD L ++G Sbjct: 4 MEETVVRIGTRKSQLAMIQTHSVVDALREIHPKARIEIVTMDTIGDRVLDKALPEIGQTN 63 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF K+LEVAL +N+ D+ +HS+KDVP P+GL + I Sbjct: 64 LFTKDLEVALTDNKIDLIIHSLKDVPSTLPEGLAIAAI---------------------- 101 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGL 179 G+++GTSSLRR QL R P L ++RGN+ TRL KLD G YDA++LA AG++ Sbjct: 102 -GNVIGTSSLRRIAQLKRRFPHLKFENVRGNLNTRLKKLDESGIYDALVLAGAGVE---- 156 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 L P+ L A+GQGA+GIE R +D +T L++A ++ + AERA L+ Sbjct: 157 -------LTPDECLYAIGQGALGIEIRKNDKKTFSLISAYTDFDSLVCNAAERAFLRFLD 209 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ------------------ 281 GC VPIG Y E + ++ + V + DGS+ ++ Sbjct: 210 KGCSVPIGVYTEFTENKLKITGAVFSLDGSKRVQYSDECTISGLNAKDDCESNYESLSSI 269 Query: 282 -----------DAEQMGISLAEELLNNGAREILAEVYN 308 +AE++G +AE +L N E+LAE Sbjct: 270 LCPSEMCNSLIEAERLGKYVAEMILKNHGGEVLAEARQ 307 >UniRef50_B0D5Q2 Predicted protein n=1 Tax=Laccaria bicolor S238N-H82 RepID=B0D5Q2_LACBS Length = 340 Score = 322 bits (825), Expect = 2e-86, Method: Composition-based stats. Identities = 120/315 (38%), Positives = 171/315 (54%), Gaps = 10/315 (3%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + I R S LA QA V+ +L P E+ I + + + GG L+ Sbjct: 16 QKAIVIGCRPSTLAKIQAELVRSRLKVLFPASRFEISSKKFPQPEIGTSQITERGGASLW 75 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDAL 119 ELE AL + DI VHS+KDVP + +G ++ + ERED RD V + Y +L+ L Sbjct: 76 TTELEDALFDGDIDILVHSLKDVPTKLKEGCEIIHVLEREDRRDCLVVKDGLPYRTLEEL 135 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAGLKRL 177 PAGS+VGT S+RR Q+ R P L+I+ +RGN+ TRL KLD+ + Y A+ILA AGL RL Sbjct: 136 PAGSVVGTGSVRRVAQMKRRYPLLVIKDVRGNIDTRLQKLDSPDLPYTALILASAGLLRL 195 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 L RI + L P IS PAVGQG +G E R D++ + +++ L + V AERA+ Sbjct: 196 SLHDRITSYLSPPISYPAVGQGCLGAEFRSADTKVKAMVSRLEVWQDGWAVRAERALLWV 255 Query: 238 LEGGCQVPIGSYAELIDGEIWLR--ALVGAPDGSQIIRGERRGAPQDAE---QMGISLAE 292 LEGGC P+G ++ I +++ +PDGS+ I E G E ++G A Sbjct: 256 LEGGCAFPVGIWSSWSGDNIASESLSVMTSPDGSEEITVETTGVVASVEEVLELGKQAAR 315 Query: 293 ELLNNGAREILAEVY 307 LL G R I+ ++ Sbjct: 316 SLLEKGGRGIIVDLR 330 >UniRef50_B9XN63 Porphobilinogen deaminase n=1 Tax=bacterium Ellin514 RepID=B9XN63_9BACT Length = 332 Score = 321 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 127/329 (38%), Positives = 172/329 (52%), Gaps = 38/329 (11%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG---K 59 + + IATR S LAL QA+ V + ++ P L +EL + T GD + LAK G K Sbjct: 6 NKPIFIATRGSALALAQANAVLSQCRSAFPKLDIELKIIKTTGDKLQKASLAKEGESLPK 65 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSL--- 116 GLF KELEVALL ADIAVHS+KD+P E P GL L + +R D RD V + + L Sbjct: 66 GLFTKELEVALLNGDADIAVHSLKDLPTELPTGLILGAVSKRADVRDVLVYRDAEYLRSQ 125 Query: 117 ---------------DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN 161 P G+ V TSS RR+ QL +R DL + +RGNV TRL KL N Sbjct: 126 PGKSNRRGFTPKLAIKDFPPGATVATSSTRRKAQLLAQRGDLNVVEIRGNVATRLEKLAN 185 Query: 162 -GEYDAIILAVAGLKRLGL--------------ESRIRAALPPEISLPAVGQGAVGIECR 206 E DA +LA AGL+RL E + L ++ LP VGQ A+G+E R Sbjct: 186 QPELDATVLAAAGLERLNFKITAEGKLAGEGIPEGLLATILDFDVMLPCVGQAALGMEIR 245 Query: 207 LDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAP 266 +D+R +E+ LNH ET V AER+ + + GGCQ P+ +YAE+ ++ +RA Sbjct: 246 ENDARIQEICDRLNHPETHACVLAERSFLSGMGGGCQSPVAAYAEIAGDQLQMRAASFRE 305 Query: 267 DGSQIIRGERRGAPQDAEQMGISLAEELL 295 + R + +A +G LA +L Sbjct: 306 --TSARRAVGGKSINEAVALGQELAAKLK 332 >UniRef50_A0QLI0 Porphobilinogen deaminase n=69 Tax=Actinomycetales RepID=HEM3_MYCA1 Length = 315 Score = 321 bits (823), Expect = 2e-86, Method: Composition-based stats. Identities = 133/309 (43%), Positives = 176/309 (56%), Gaps = 13/309 (4%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 ++RI TR S LA QA V+D L+A G ELV + T GD P+ +G G+F Sbjct: 1 MIRIGTRGSLLATTQAGGVRDALIAR--GHPAELVTITTAGDRS-SGPIESLG-VGVFTT 56 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L A+ E R D AVHS KD+P + I R DPRDA V+ + L LP GS+ Sbjct: 57 ALREAIEEGRVDAAVHSHKDLPTADDPRFAVAAIPARNDPRDAVVARDGLVLGELPPGSL 116 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGTSS RR QL L IR LRGN+ TRL+++ +G+ DAI++A AGL RLG + Sbjct: 117 VGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLGDVT 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L P LPA QGA+ +ECR DSR +LA L+ +T VTAERA+ LE GC Sbjct: 177 ETLEPVQMLPAPAQGALAVECRAGDSRLAAVLAELDDADTRASVTAERALLAELEAGCSA 236 Query: 245 PIGSYAELID---------GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295 P+G+ AE+++ E+ LR V A DGS +IR G P A ++G+S+A EL Sbjct: 237 PVGAIAEVVESIDEDGRIFEELSLRGCVAALDGSDVIRASGIGTPGRARELGLSVAAELF 296 Query: 296 NNGAREILA 304 GARE+++ Sbjct: 297 ELGARELMS 305 >UniRef50_C5RMN3 Porphobilinogen deaminase n=1 Tax=Clostridium cellulovorans 743B RepID=C5RMN3_CLOCL Length = 300 Score = 320 bits (821), Expect = 4e-86, Method: Composition-based stats. Identities = 114/301 (37%), Positives = 170/301 (56%), Gaps = 8/301 (2%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + ++RI TR+S LAL Q + V D + HP + E+V M T+GD ILD L GGKG Sbjct: 1 MKKIIRIGTRKSKLALMQTNIVIDAIKKKHPEINCEVVEMSTKGDEILDKSLLSFGGKGA 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS-NNYDSLDAL- 119 FV E E A+ D+AVHS KD+P++ GL +V + +REDPRD V+ NN D+++ Sbjct: 61 FVSEFEKAIKSGEIDLAVHSAKDMPMDLLTGLKIVAVTKREDPRDVLVTANNKDTINDFN 120 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 ++GT+SLRR+ Q+ ++ + LRGNV RL KL +GEYD IILA AGLKRLGL Sbjct: 121 KTNKLIGTTSLRRKLQIKRLLNNVDTKDLRGNVQRRLEKLISGEYDGIILAAAGLKRLGL 180 Query: 180 ESRIR---AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236 R L E +PA GQG + +E R + L ++++ E + ER + Sbjct: 181 LDDERINLNYLSVEDFIPAGGQGIIAVEGRAE-EEFSFLKDSIHNEEAMYSLEVERYVMK 239 Query: 237 RLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 +L GC PIG+Y+ + I+L ++ +G + R + + ++ ++ L EE+L Sbjct: 240 KLNAGCNEPIGAYSFIDKDTIFLD-IIYEHNGK-VSRKKGSDSIENRLKLTEKLVEEILQ 297 Query: 297 N 297 Sbjct: 298 E 298 >UniRef50_C1TM53 Porphobilinogen deaminase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TM53_9BACT Length = 454 Score = 320 bits (821), Expect = 4e-86, Method: Composition-based stats. Identities = 124/289 (42%), Positives = 159/289 (55%), Gaps = 8/289 (2%) Query: 10 TRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVA 69 +R+S LA Q L GL VE+ M T GD D L+ GG G FVK LE A Sbjct: 160 SRKSALARAQTMEAARALAKK--GLPVEIKTMSTCGDEKQDCHLSAFGGNGAFVKCLEEA 217 Query: 70 LLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSS 129 ++E + D A+HS+KDVP P GL LV + R D VSN+ L+ LPAG++VGTSS Sbjct: 218 IMEGKGDGAIHSLKDVPSVLPDGLELVAVLPRASTSDVIVSNHKGGLEGLPAGAVVGTSS 277 Query: 130 LRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPP 189 LRR+ QLA RPDL +RGNV TRL+KL +G+ DAI+LA AGL RLG+ LP Sbjct: 278 LRRKAQLAITRPDLDYTLIRGNVNTRLAKLQSGDADAIVLAKAGLDRLGISPEGATTLP- 336 Query: 190 EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSY 249 LPA QG + +E R SR E A+NH T L AER + L+ GC VP + Sbjct: 337 --FLPAPCQGIIAVEARSG-SRLAEEFRAINHRPTWLMALAERELLESLQVGCHVPFAAL 393 Query: 250 AELIDGEIWLRALVGAPDGSQI-IRGERRG-APQDAEQMGISLAEELLN 296 +E + GE+ LRA + DG I G + DA +G +A + Sbjct: 394 SEWVGGELRLRAQTLSYDGRHIDFEGSLAVRSDDDARDLGRDVALSIKA 442 >UniRef50_D2NS36 Porphobilinogen deaminase n=2 Tax=Micrococcaceae RepID=D2NS36_9MICC Length = 454 Score = 320 bits (820), Expect = 5e-86, Method: Composition-based stats. Identities = 134/372 (36%), Positives = 186/372 (50%), Gaps = 71/372 (19%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPG------------LVVELVPMVTRGDVI 48 M + + TR S LAL Q+ + + + + + L + T GD + Sbjct: 78 MSHHEYILGTRGSALALTQSRIAAETVTSLYTEHQAHHGAADAEVVDFTLRTVKTEGD-V 136 Query: 49 LDTPLAKVGGKGLFVKELEVALLENR-------ADIAVHSMKDVPVEFPQGLGLVTICER 101 L PLA +GG G+F L LL+ D+AVHS+KD+P GL + +R Sbjct: 137 LTGPLATLGGTGVFAAALRQRLLDGENASEENRVDMAVHSLKDLPSAPCPGLVIAATLKR 196 Query: 102 EDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-- 159 EDPRDA V+ + +LD LP GS VGT S RR QL RPDL I +RGNVGTR+ ++ Sbjct: 197 EDPRDALVARDGLTLDTLPEGSRVGTGSPRRAAQLRALRPDLEIVDIRGNVGTRIGRVKG 256 Query: 160 ----------------------------DNGEYDAIILAVAGLKRLGLESRIRAALPPEI 191 +G+ DA++LAV+GLKRLG E I L P Sbjct: 257 LEEHAGKQVVLRQNTETSERADHGVGTERSGDCDAVVLAVSGLKRLGKEELITEYLDPTR 316 Query: 192 SLPAVGQGAVGIECRLD-----------DSRTRELLAAL-------NHHETALRVTAERA 233 LPA GQGA+ +E R D + AL NHHET L V+AERA Sbjct: 317 MLPAPGQGALALEVRESEFENPDPAVLADPEVARPVRALGRALLAANHHETRLAVSAERA 376 Query: 234 MNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---AEQMGISL 290 + RLE GC PIG+YA +++G++ L +V +PDG+ ++R A D AE++G+ + Sbjct: 377 LLRRLEAGCAAPIGAYAHVVEGDLVLSVVVASPDGTDMLRHTSATAELDVPGAERLGVRV 436 Query: 291 AEELLNNGAREI 302 AE+LL GA + Sbjct: 437 AEDLLQMGAAAL 448 >UniRef50_B6W7F3 Putative uncharacterized protein n=1 Tax=Anaerococcus hydrogenalis DSM 7454 RepID=B6W7F3_9FIRM Length = 318 Score = 319 bits (819), Expect = 6e-86, Method: Composition-based stats. Identities = 106/310 (34%), Positives = 162/310 (52%), Gaps = 12/310 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +++I +R S LAL QA+ VKD L GL ++V + T+GD I D + ++ KG+FV+ Sbjct: 1 MIKIGSRASKLALIQANMVKDILEKE--GLEAQIVEISTKGDRIRDRKIDQLNSKGVFVR 58 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALPAGS 123 E+E LL+ DIAVHS+KD+P + L + EDPRD FV + + +D L + Sbjct: 59 EIEEKLLDKTIDIAVHSLKDMPSQIDDRLIFTPPLKGEDPRDCFVGKDVFKKMDDL-NNA 117 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +VGT S RR CQ ++ +++RGNV TR+ K+ + D +ILA +GL R GL+ I Sbjct: 118 LVGTGSNRRVCQGKNHFSNIKFKAIRGNVETRIKKVQSENLDGVILAKSGLIRAGLDGEI 177 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 L P I P+ QG +GIE R +D + E+ + +T R+ ERA L C Sbjct: 178 NFDLDPHIFTPSPCQGILGIEIRKEDKKLFEIFKKNSDEKTLFRMETERAFQKELGADCS 237 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 P+G + E+ +I L + +I G + I LA++L AR + Sbjct: 238 TPMGIFTEIDHDKITLTGSMAFDKDDRINYERVSGNISE----RIHLAQKL----ARTLK 289 Query: 304 AEVYNGDAPA 313 + Y + P Sbjct: 290 KKSYKKNNPC 299 >UniRef50_D1VCA1 Porphobilinogen deaminase n=1 Tax=Frankia sp. EuI1c RepID=D1VCA1_9ACTO Length = 380 Score = 317 bits (814), Expect = 3e-85, Method: Composition-based stats. Identities = 124/344 (36%), Positives = 180/344 (52%), Gaps = 44/344 (12%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 L + LR+ TR+S LAL Q+ V D+L G+ V+LV +VT GD ++++G G+ Sbjct: 36 LPSRLRLGTRRSALALAQSGMVADELRTR-LGIEVDLVHVVTEGDRNR-AEISQLGSTGV 93 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 +V L ALL D+AVHS+KD+P P+G+ L I RED RD VS +L L Sbjct: 94 WVSALREALLSGEVDLAVHSLKDLPTAPPEGITLAAIPPREDVRDVLVSPTGRTLAQLGP 153 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ +GT + RR QL L + +RGNV TR+ K +GE DA++LA AGL RL Sbjct: 154 GARIGTGAPRRAAQLRALGLGLDVVPIRGNVDTRIKKAIDGEVDAVVLARAGLARLDRLD 213 Query: 182 RIRAALPPEISLPAVGQGAVGIECRL--------------DDSR---------------- 211 I L PE+ LPA GQGA+ IEC +D Sbjct: 214 AITELLEPEVMLPAPGQGALAIECVATTLAPLTLLTVGTPEDQGAVTGMSCPVAPGSGVE 273 Query: 212 --TRELLA-ALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELI---------DGEIWL 259 LL L+ +++ V AERA +E GC P+G+ A+++ +GE+ L Sbjct: 274 IPLERLLRFVLDDAPSSVAVRAERAFLAAIEAGCTAPVGALAQVLPARGQAPASEGEVRL 333 Query: 260 RALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 RA+V + DG+ ++R E G+ D E +G LA++LL+ GA ++ Sbjct: 334 RAVVASLDGTTVLRRELGGSTADPEALGRRLADDLLSAGAHTLM 377 >UniRef50_UPI000174444E Hydroxymethylbilane synthase n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI000174444E Length = 318 Score = 317 bits (813), Expect = 3e-85, Method: Composition-based stats. Identities = 119/307 (38%), Positives = 156/307 (50%), Gaps = 18/307 (5%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG----- 57 + LR+ TR S LAL QA V+ L A+HP L VE + T GD D ++ Sbjct: 6 TDTLRLGTRGSELALRQAEMVEAALHAAHPYLRVERKVIATTGDKRPDLRFSEFTEGDRL 65 Query: 58 GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD 117 KG+F KELE+AL DIAVHS+KDVP + + + R D +S +L Sbjct: 66 DKGIFTKELEIALASGEIDIAVHSLKDVPTVLDEKFFIAGVLPRAPIEDVLISREGYTLA 125 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-DNGEYDAIILAVAGLKR 176 LPAG+ VGTSS+RR QL P + +RGNV TR+ KL + DAI+LA AGL+R Sbjct: 126 TLPAGAKVGTSSVRRIRQLQWLNPGVECVEIRGNVPTRIRKLFAPSDLDAILLARAGLER 185 Query: 177 LGLES----------RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETAL 226 L L L E LPA GQGA+GIE R+DD+ T E L A+NH ET Sbjct: 186 LSLLDGEHVVVDGQPLHAVILDCEEFLPAAGQGAIGIEARVDDAHTLEFLKAINHEETYA 245 Query: 227 RVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPD--GSQIIRGERRGAPQDAE 284 RVTAER L+ GCQ PIG++ L +G + ++ V G + Sbjct: 246 RVTAEREFLHILKAGCQTPIGAHTFLENGVLQMKVRVFDETDPGRPPKEVTSTEPYHSPK 305 Query: 285 QMGISLA 291 + +A Sbjct: 306 GLAAEVA 312 >UniRef50_C6R3Y0 Hydroxymethylbilane synthase n=1 Tax=Rothia mucilaginosa ATCC 25296 RepID=C6R3Y0_9MICC Length = 377 Score = 317 bits (813), Expect = 4e-85, Method: Composition-based stats. Identities = 134/372 (36%), Positives = 187/372 (50%), Gaps = 71/372 (19%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPG------------LVVELVPMVTRGDVI 48 M + + TR S LAL Q+ + + + + + EL + T GD + Sbjct: 1 MSHHEYTLGTRGSALALTQSRIAAETVTSLYTEHQAHHGAENPEAVSFELRTVKTEGD-V 59 Query: 49 LDTPLAKVGGKGLFVKELEVALLENR-------ADIAVHSMKDVPVEFPQGLGLVTICER 101 L PLA +GG G+F L LL+ D+AVHS+KD+P GL + +R Sbjct: 60 LTGPLATLGGTGVFAAALRQRLLDGENASEENRVDMAVHSLKDLPSAPCPGLVVAATLKR 119 Query: 102 EDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-- 159 EDPRDA V+ + ++D LP GS VGT S RR QL RPDL I +RGNVGTR+ ++ Sbjct: 120 EDPRDALVARDGLTVDTLPEGSRVGTGSPRRAAQLRALRPDLEIVDVRGNVGTRIGRVKG 179 Query: 160 ----------------------------DNGEYDAIILAVAGLKRLGLESRIRAALPPEI 191 +G+ DA++LAV+GLKRLG E I L P Sbjct: 180 LEEHAGKQVVLRQNAETSERADHGVGTERSGDCDAVVLAVSGLKRLGKEELITEYLDPTR 239 Query: 192 SLPAVGQGAVGIECRLD-----------DSRTRELLAAL-------NHHETALRVTAERA 233 LPA GQGA+ +E R D + AL NHHET L V+AERA Sbjct: 240 MLPAPGQGALALEVRESEFENPDSAVLADPEVARPVRALGRALLAANHHETRLAVSAERA 299 Query: 234 MNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---AEQMGISL 290 + RLE GC PIG+YA +++G++ L +V +PDG+ ++R A D AE++G+ + Sbjct: 300 LLRRLEAGCAAPIGAYAHVVEGDLVLNVVVASPDGTDMLRHTSATAELDVPGAERLGVRV 359 Query: 291 AEELLNNGAREI 302 AE+LL GA + Sbjct: 360 AEDLLQMGAAAL 371 >UniRef50_B6JII8 Porphobilinogen deaminase n=11 Tax=Bradyrhizobiaceae RepID=B6JII8_OLICO Length = 338 Score = 317 bits (812), Expect = 4e-85, Method: Composition-based stats. Identities = 112/323 (34%), Positives = 161/323 (49%), Gaps = 18/323 (5%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 + D +RI TR+S +AL Q + +L A+ P L VE+V T GD L +GGKG Sbjct: 9 VTDKAMRIGTRKSVMALAQTSEIARQLTAADPALDVEIVKFETTGDQDQTGKLLDLGGKG 68 Query: 61 -LFVKELEVALLENRADIAVHSMKDVPV-EFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118 FV ++ A+ E R + A+HS+KD+P E GL + R+ P DA V + +L Sbjct: 69 GAFVAQIRDAVREGRLEAAMHSLKDMPGNEDTPGLVIGATLTRDPPTDALVVRHGVTLAD 128 Query: 119 L----PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE----------- 163 L G +GT+++RR + P+ I RG TR+ KLDNGE Sbjct: 129 LRRTGGKGFKIGTNAVRRAAYVRRLFPECEIIHFRGAADTRIRKLDNGEKQRLPEGGEVG 188 Query: 164 -YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHH 222 DA+++A AGL+R+G RI P+ LPAVGQG V +EC D T LA ++ Sbjct: 189 PADALVMAQAGLERVGCADRIAHCFSPDEILPAVGQGIVAVECAASDWCTLARLAQIDDP 248 Query: 223 ETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD 282 + AER + L G C PI YA + ++ L+A V I RRG Sbjct: 249 VSRCCAAAEREVLWVLNGHCNSPIAGYAIVEGDDVLLKAAVLDEANDHFIEVTRRGPASR 308 Query: 283 AEQMGISLAEELLNNGAREILAE 305 ++G ++A ELL GA +++A Sbjct: 309 PRELGRAVAFELLAKGAADVIAR 331 >UniRef50_C2FZW8 Porphobilinogen deaminase n=2 Tax=Sphingobacterium spiritivorum RepID=C2FZW8_9SPHI Length = 528 Score = 316 bits (811), Expect = 6e-85, Method: Composition-based stats. Identities = 112/311 (36%), Positives = 158/311 (50%), Gaps = 24/311 (7%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 ++ L I TR S LA+WQA+++KD+L A+ G+ EL + T+GD+I L K+ GKG Sbjct: 1 MNRKLIIGTRGSQLAMWQANHIKDRLAAA--GIDSELKVIKTQGDIIQHLRLDKLEGKGF 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY----DSLD 117 F KELE LL + D+AVHS KD+P P GL + + ERE P + + Sbjct: 59 FTKELEEELLSSTIDLAVHSHKDLPTVNPPGLIIAAVSERESPAELLIVLKDCVDIKKRL 118 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKR- 176 +L + VGTSS RR+ QL RPDL LRGN+ TR+ KL + YDAIILA AG++R Sbjct: 119 SLKHNATVGTSSNRRKAQLLSLRPDLEFDDLRGNLQTRIQKLRDENYDAIILAKAGVERI 178 Query: 177 -LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235 + L +PP +PA QG + I+ R D E L +++ E A + ER + Sbjct: 179 DMDLSDFYVEEIPPVELIPAPAQGVLAIQIRESDQELFEALQVIHNKEVAEVIAVERKVL 238 Query: 236 TRLEGGCQVPIGSYAELIDGEIWLRALVGA-----PDGSQIIRGERRGAPQDAEQMGISL 290 + GC P+G Y +G+ V PD I R G + Sbjct: 239 NLFDAGCHAPLGCYCRKSEGKYEAWTSVAETSDEFPDRLYIQRDSTEG-----------M 287 Query: 291 AEELLNNGARE 301 AEE+ A++ Sbjct: 288 AEEIFTKFAKD 298 >UniRef50_A8AAB4 Probable porphobilinogen deaminase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=HEM3_IGNH4 Length = 304 Score = 316 bits (811), Expect = 6e-85, Method: Composition-based stats. Identities = 113/294 (38%), Positives = 158/294 (53%), Gaps = 7/294 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILD--TPLAKVGGKGLFV 63 ++IA R S L+L Q L+ P L E++ + T GD LAK G GLF Sbjct: 3 IKIAARGSKLSLKQVSMFTSYLLKFFPDLEYEVITVKTTGDKANAPFEELAKRGLTGLFE 62 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD-SLDALPAG 122 KE+ A+LE +AD+AVHS+KD+P E L + R+ P D +S + + LP G Sbjct: 63 KEVNKAVLEGKADVAVHSLKDLPTELDPRLEIAAFLPRDPPYDVLISRAGNYDIFDLPKG 122 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 S+VGTSS RR+ + RPDL+++ LRGNV TRL KL GEYDAI+LA AG+ RLGL + Sbjct: 123 SVVGTSSARRKALIKNLRPDLVVKDLRGNVDTRLEKLRRGEYDAIVLAEAGVSRLGL-NV 181 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 L + P+ GQG + R S +LL +++ ++ TAER + GGC Sbjct: 182 DYVRLDWRLFPPSPGQGIIVAVTRKG-SEISDLLKSISDVKSEKLATAERTVLKEFGGGC 240 Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 V +G+ A I LRA V +P G + + E G E++G+ AE L Sbjct: 241 FVALGAIAFEEGSLIRLRATVLSPSGRERVDVELIGKG--PEEVGMRAAERLKA 292 >UniRef50_C9M5W1 Hydroxymethylbilane synthase n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M5W1_9BACT Length = 714 Score = 316 bits (810), Expect = 7e-85, Method: Composition-based stats. Identities = 116/297 (39%), Positives = 161/297 (54%), Gaps = 7/297 (2%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 L LR+A+R+S LA+ Q+ V ++L + G VE++P TRGD + D L GGKGL Sbjct: 422 LGRPLRLASRESELAMAQSRLVAERLHEA-TGFDVEIIPFRTRGDAVADRRLESAGGKGL 480 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKELE A+L +AD+AVHS+KD+P P GL + +R+ D V + + Sbjct: 481 FVKELERAILSGQADLAVHSLKDMPSSCPDGLAFAALMDRQTAFDCLVLRPGLTGRPV-- 538 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 +GTSS RR Q D LRGN+ TRLSKLD GE+DA+ILA AGL+RLGL+ Sbjct: 539 --RIGTSSARRIAQGRALFSDAQFVPLRGNLRTRLSKLDGGEFDALILAEAGLRRLGLQE 596 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 R+ + +P+ GQG + ++C D +L++ L+ AERA RL GG Sbjct: 597 RVSRVFSADQMIPSAGQGTLAVQCPFDGP-VFDLVSQLDEPAVRTCCLAERAFIDRLNGG 655 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 C P G+YA + I + L PDG + G+ G D + LA+ L G Sbjct: 656 CTAPHGAYARVDGETIEMIGLYVRPDGKT-LSGKISGPAADGPSLAAELADRLKRRG 711 >UniRef50_Q1EPC8 Porphobilinogen deaminase, chloroplast (Hydroxymethylbilane synthase) (Pre-uroporphyrinogen synthase), putative n=1 Tax=Musa acuminata RepID=Q1EPC8_MUSAC Length = 328 Score = 316 bits (810), Expect = 8e-85, Method: Composition-based stats. Identities = 126/296 (42%), Positives = 163/296 (55%), Gaps = 34/296 (11%) Query: 11 RQSPLALWQAHYVKDKLMASHPGLV----VELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66 R S LAL QA +DKL A+H L VE++ + T GD+ILD PLA +GGKGLF KE+ Sbjct: 54 RDSDLALAQARETRDKLKAAHSELAEEGAVEIIIIKTTGDMILDKPLADIGGKGLFTKEI 113 Query: 67 EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126 + ALL+ R DIAVHSMKDVP P+G L Sbjct: 114 DDALLQGRIDIAVHSMKDVPTYLPEGTILPCNLP-------------------------- 147 Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAA 186 +SLRRQ Q+ R P L + +LRGNV TRL+KL NG+ A +LA+AGLKRL + + + Sbjct: 148 -ASLRRQSQILCRYPSLKVVNLRGNVQTRLTKLKNGDVHATLLALAGLKRLNMVENVTSI 206 Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246 L E LPAV QGA+GI CR +D++ E L++LNH +T V ER T L+G C+ PI Sbjct: 207 LSMEEMLPAVAQGAIGIACRSNDNKMMEYLSSLNHEDTRSAVACEREFLTVLDGNCRTPI 266 Query: 247 GSYAELI-DGEIWLRALVGAPDGSQIIRGERRGA--PQDAEQMGISLAEELLNNGA 299 +YA DG R L+ +PDGS++ R G D +MG EL Sbjct: 267 AAYAHRDKDGSCSFRGLLASPDGSKVYETTRIGPYSFDDMVEMGKDAGHELKAKAG 322 >UniRef50_Q57989 Probable porphobilinogen deaminase n=11 Tax=Methanococcales RepID=HEM3_METJA Length = 292 Score = 315 bits (808), Expect = 1e-84, Method: Composition-based stats. Identities = 106/297 (35%), Positives = 158/297 (53%), Gaps = 10/297 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 ++RI TR S LAL+QA+ V + L + G VE+ + T GD +LD L+ +G G+F K Sbjct: 1 MIRIGTRGSKLALYQANKVAELLK--NLGYKVEIKIIKTTGDRVLDKKLSDIG-IGVFTK 57 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 EL++A+L N DIAVHS+KD+P + + L + + ER+ D + N + + + Sbjct: 58 ELDLAMLNNEIDIAVHSLKDIPTIWNENLMVGAVLERDSYHDLLIWNKDIDFNE-DSKIV 116 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSS+RR+ L P+ LRGNV TRL KL G YDAI+L+ AG+ RLG+ Sbjct: 117 IGTSSMRRRAFLKFIYPNAKFELLRGNVDTRLRKLKEGLYDAIVLSEAGIIRLGVSLEDF 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 +I LPA QG + + C+ DD + +L +NH T L ER GGC V Sbjct: 177 NYKRLDI-LPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSV 235 Query: 245 PIGSYAELIDGE--IWLRALVGAPDGSQIIRGERRGAPQD---AEQMGISLAEELLN 296 P G+ A + + L+A V D + GE + + A ++G + +L N Sbjct: 236 PFGALAVYDEKNELLKLKAAVVTNDELKNASGEVKCKIDEIDKAVELGKKIGLKLKN 292 >UniRef50_D2RH82 Porphobilinogen deaminase n=2 Tax=Archaeoglobaceae RepID=D2RH82_ARCPR Length = 292 Score = 315 bits (807), Expect = 2e-84, Method: Composition-based stats. Identities = 111/296 (37%), Positives = 166/296 (56%), Gaps = 11/296 (3%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + + + TR S LAL Q V ++L G VE+ + + GD++ D PL + G G Sbjct: 1 MSERVVVGTRGSKLALAQTSKVVERLKEE--GYSVEIRIIKSTGDIMKDKPLYEFKGSGA 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FV+ LE AL+ D+AVHS KD+P +G+ + + ER+ P DAF++ N +SL+ + Sbjct: 59 FVRALEHALVRGEIDVAVHSYKDIPSNMLEGVTVSAVLERDSPYDAFIARNGESLEEIKP 118 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 +++GTSSLRR+ QL R DL +LRGNV TRL KL G YDAI+LA AG++RLGL Sbjct: 119 NAVIGTSSLRRRAQLKLYRSDLRFENLRGNVDTRLRKLREGLYDAIVLAEAGIQRLGLNV 178 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + LP E +P QG + ++ R+ + +L+ +NH ET + ER + L G Sbjct: 179 K-YQRLPIERFVPPANQGIIAVQTRVGEE---DLVKFMNHEETWIEAEVERIVMKTLGVG 234 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQ---IIRGERRGAPQDAEQMGISLAEEL 294 C +P G YAE G++ L V DG + I R A ++A ++ + EE+ Sbjct: 235 CAIPAGIYAECR-GKVRLIVQVIR-DGREFKVIEELSRESAIEEAREIAENFREEV 288 >UniRef50_Q2NEP4 HemC n=4 Tax=Methanobacteriaceae RepID=Q2NEP4_METST Length = 290 Score = 314 bits (805), Expect = 3e-84, Method: Composition-based stats. Identities = 91/292 (31%), Positives = 149/292 (51%), Gaps = 4/292 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 + + TR S LA Q V L G +E + T GD I ++ L + KG+F KE Sbjct: 1 MIVGTRGSKLATTQTKTVVKALEEIT-GEEIETKIIKTTGDKIKNSQLYNIDAKGIFTKE 59 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L+ AL++ D AVHS KD+P E L + I +RE + +SN S D LP + + Sbjct: 60 LDTALIDGSIDFAVHSFKDLPSELNDQLTITAIPQREAINEVLISNY--SWDELPENATL 117 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR+ + + +RGN+ TR+ K++ GEYDA I+A+AG+ RLGL+ I+ Sbjct: 118 GTSSVRREAFCKLHGKKIQTKPIRGNIDTRIRKVEEGEYDATIMALAGINRLGLQEHIKE 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 + P GQGA+ + DS ++++ LNH ++ + E+A+ + GCQ P Sbjct: 178 VFDEQYITPPAGQGALAVMTHK-DSEYNDVISKLNHEDSRIEAMTEKAILETIGVGCQWP 236 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 IG +++ I + + +P+G + + +A + +L + Sbjct: 237 IGIVSKVDGNNINIHCKLLSPEGKLLADVNKTTDKNNAINTAKVIGTKLRED 288 >UniRef50_A4WN24 Probable porphobilinogen deaminase n=3 Tax=Thermoproteaceae RepID=HEM3_PYRAR Length = 297 Score = 313 bits (804), Expect = 4e-84, Method: Composition-based stats. Identities = 110/293 (37%), Positives = 157/293 (53%), Gaps = 6/293 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L +ATR S L++ Q + ++ A P + E+ + T GD + D PL ++G KG+F KE Sbjct: 3 LVVATRGSKLSMLQTEELLAQIKAVEPSIEFEIKIVKTTGDEVQDKPLYQIGVKGIFEKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 + +A+L AD+AVHS+KD+P E GL L +R P DA VS L+ LP G++V Sbjct: 63 VNLAVLRGEADVAVHSLKDLPSELSPGLVLAGFSKRAPPFDAVVSTAGYVLETLPRGALV 122 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL-GLESRIR 184 GTSS+RR + RPD+ + LRGNV TR++K+ G+YDA I+AVAG+ RL G I+ Sbjct: 123 GTSSVRRAEFVKAIRPDVRVEPLRGNVDTRINKILQGKYDAAIMAVAGIYRLYGASPPIK 182 Query: 185 -AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 A L PE+ P GQG V R DS +LL + + +L AER + GC Sbjct: 183 LAVLRPEVLPPPPGQGIVAAVVREADSWLIDLLKKASDPKASLEAIAEREFLKAVGAGCH 242 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 V IG A + + A + G + G D ++G AEE+ Sbjct: 243 VAIGGVAFARNDTVEFIAGYAS--GGRKYIVRVVG--DDPVEVGRRAAEEIRK 291 >UniRef50_C0BZ93 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM 15053 RepID=C0BZ93_9CLOT Length = 298 Score = 312 bits (800), Expect = 1e-83, Method: Composition-based stats. Identities = 120/297 (40%), Positives = 163/297 (54%), Gaps = 7/297 (2%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + +++RI +R+S LA+ QA VK + + P + E+V M T GD ILD L GGKGL Sbjct: 1 MQSIIRIGSRESRLAVKQAEIVKQAVERNCPDIKAEIVTMKTEGDKILDRRLELAGGKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKELE ALL+ R DI VHS+KDVP+E P+ L +V EREDPRD + + ++P Sbjct: 61 FVKELEKALLDGRIDICVHSLKDVPMEVPEDLPVVAFGEREDPRDVLIYKPGRT--SIPE 118 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G ++GTSS RR+ QL P RS+RGNV TRL KL +D +LA AGLKRL +E Sbjct: 119 GGVIGTSSRRRELQLKRLYPSCTFRSIRGNVQTRLRKLSEEGFDGTVLAAAGLKRLHMEE 178 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + +PAVGQG + ++ R L + ++ AER L GG Sbjct: 179 VAGRVFSVDEIIPAVGQGILAVQGRKGRDY--SWLTSFACGKSRAEAEAEREFAAALGGG 236 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRG-ERRGAPQDAEQMGISLAEELLNN 297 C P+ ++A+ E+ L L G I R R G A Q+G +LAEE+ Sbjct: 237 CTSPVAAHAQAQGAELKLTGLYYC--GGDIYRTRTRTGETDRARQLGAALAEEMRRE 291 >UniRef50_A1DGB8 Porphobilinogen deaminase n=1 Tax=Neosartorya fischeri NRRL 181 RepID=A1DGB8_NEOFI Length = 363 Score = 312 bits (799), Expect = 1e-83, Method: Composition-based stats. Identities = 120/344 (34%), Positives = 164/344 (47%), Gaps = 39/344 (11%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKL-MASHPGLVVELVPMVTRGDVILDTPLAKVG---- 57 + V+ R+S LAL Q +V KL P ++ GD P A + Sbjct: 20 EEVVIFGCRKSELALVQTRWVTSKLGQTLDPSPTFQIATGSAVGDADKQAPFAVLSKLTG 79 Query: 58 ----GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN-- 111 GK L+ ELE+ L+ + VHS+KD+P P L + ERED DA Sbjct: 80 GSDIGKSLWTNELELDLVAGKVHCLVHSLKDMPTTLPPHCLLGAVPEREDCSDAVCMRSD 139 Query: 112 -NYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAII 168 + S+D LP GSIVGTSS RR+ + P L + RGNV TRL+KLD + + I+ Sbjct: 140 LKFTSIDQLPPGSIVGTSSSRRKALVRRNWPHLEVVECRGNVDTRLAKLDAPSSRFSCIL 199 Query: 169 LAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRV 228 LA AGL RLGL RI L I AVGQGA+G+E D EL+ ++H + R Sbjct: 200 LATAGLLRLGLGHRITHRLDDSIFPYAVGQGALGLEVSTDRPDILELVRHVDHKPSRWRG 259 Query: 229 TAERAMNTRLEGGCQVPIGSYAELI----------------------DGEIWLRALVGAP 266 AERAM L+GGC PIG + L G + LRA+V Sbjct: 260 IAERAMLRSLQGGCSSPIGVQSSLEPLGKEENGSTEDDSQRGRDSSSGGNLSLRAMVLHI 319 Query: 267 DGSQIIRGERRGAP---QDAEQMGISLAEELLNNGAREILAEVY 307 +G+ I E ++AE +G+S+A LL GAR ++ + + Sbjct: 320 EGTSEIVAEDMATVRCDEEAELLGVSVANMLLAKGARGLMPKQF 363 >UniRef50_C5CB88 Porphobilinogen deaminase n=5 Tax=Actinomycetales RepID=HEM3_MICLC Length = 377 Score = 311 bits (798), Expect = 2e-83, Method: Composition-based stats. Identities = 130/356 (36%), Positives = 180/356 (50%), Gaps = 61/356 (17%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 + LRI TR S LA Q +V + L A GL ELV + T GD + LA +GG G+F Sbjct: 2 SPLRIGTRGSALATTQTSHVAEALTARS-GLAHELVVIRTEGD-VTTGSLASLGGTGVFA 59 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 L A+L+ D AVHS+KD+P P+ L + + R D RDA + + +L LP G+ Sbjct: 60 SALRAAVLDGVVDAAVHSLKDLPAAQPETLEIAAVPARADLRDALCARDGLTLATLPEGA 119 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL----------------DNGEYDAI 167 VGT S RR QL RPDL + +RGNV TRL+++ G+ DA+ Sbjct: 120 RVGTGSPRRVAQLKALRPDLELVDIRGNVQTRLARVPGLEQHDDHAPAAVGSPRGDLDAV 179 Query: 168 ILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDS---------------RT 212 ILA AGL RLGL+ I + PE+ +PA GQGA+ +E R +D R Sbjct: 180 ILACAGLDRLGLDHVITERIDPEVMVPAPGQGALAMEIRAEDESFLGRALLDPEAPVGRL 239 Query: 213 RELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGE-----IWLRALVGAPD 267 L ++ +T + VTAERA+ RLE GC PIG+ A + DGE I + A+V A D Sbjct: 240 HAALELVDDRDTHVAVTAERALLRRLEAGCAAPIGAVARVGDGEAGAPRIEMTAMVAALD 299 Query: 268 GSQIIR-----------GERRGAPQ------------DAEQMGISLAEELLNNGAR 300 GS+++R + G P AE +G+ +AE+ + GA Sbjct: 300 GSRVLRRTSSVQLDPVPADVVGDPAAADEWLEDTLFVAAEALGVHVAEQFVAEGAD 355 >UniRef50_D1C4S0 Porphobilinogen deaminase n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C4S0_SPHTD Length = 311 Score = 308 bits (789), Expect = 2e-82, Method: Composition-based stats. Identities = 122/289 (42%), Positives = 158/289 (54%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +R+ TR S LA Q V L A P L + + T GD TPL +GG+G+F +E Sbjct: 11 VRLGTRGSALAREQTRRVMAALAALRPDLELIETIVSTAGDRDKRTPLTVIGGQGVFARE 70 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L+ ALL D+AVHS KD+P E GL + RED RD VS + SL LP G+ V Sbjct: 71 LQTALLAGTVDVAVHSAKDLPTEPVPGLVIGAFFSREDARDVLVSRDGRSLADLPPGARV 130 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS RR L RPDL LRGN+ TRL K+ GE DA ILA AGL R+G + I Sbjct: 131 GTSSRRRLVALRRLRPDLEAVDLRGNLDTRLRKVREGEVDAAILAAAGLLRMGWQEHITE 190 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L + +PA GQGA+ IECR DD E+LAALN AL ER+ L GGC+ P Sbjct: 191 FLSLDDFVPAPGQGALAIECRADDPAVNEMLAALNDPAAALAARTERSFLRALGGGCRSP 250 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 IG++A + + LR ++G +++ +AE +LA E+ Sbjct: 251 IGAHATVSGDTVTLRVMLGDEAMTRVRLSTWTLPAAEAETRAGALAVEV 299 >UniRef50_O26960 Probable porphobilinogen deaminase n=1 Tax=Methanothermobacter thermautotrophicus str. Delta H RepID=HEM3_METTH Length = 289 Score = 307 bits (788), Expect = 2e-82, Method: Composition-based stats. Identities = 104/286 (36%), Positives = 155/286 (54%), Gaps = 4/286 (1%) Query: 9 ATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEV 68 TR S LAL Q ++V + L + +E + T+GD I D+ L + +GLF +EL++ Sbjct: 4 GTRGSRLALVQTNHVIEML-SEVCKEKIEKKIIKTKGDRIRDSQLYSMDSRGLFTRELDM 62 Query: 69 ALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTS 128 A+L D+AVHS+KDVP + L + + RE P + VS + LP GS +GTS Sbjct: 63 AVLNEEVDLAVHSLKDVPSDLDPDLAIAAVPPRESPAEVLVSR--LDWEDLPQGSKLGTS 120 Query: 129 SLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALP 188 SLRR+ + + + LRGN+ TR+ K+ +GE A I+A AGLKRLGLE I+ P Sbjct: 121 SLRREAFCNHHQKNFKMEPLRGNIDTRIRKVMDGEVHATIMAEAGLKRLGLEEHIKRRFP 180 Query: 189 PEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGS 248 E PA GQGA+ + R DS + + HH + VTAE+ + L GCQ P+G Sbjct: 181 VEYFTPAAGQGALAVITRA-DSELISSIGRITHHPSLQEVTAEKTLLRELGAGCQCPLGV 239 Query: 249 YAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 ++ L A++ +G + + RG +AE +G A+E+ Sbjct: 240 IGRATGNQLTLYAVLLTREGEMLRKVTVRGPLAEAEDIGKKAAKEM 285 >UniRef50_UPI0001BC2D4C glutamyl-tRNA reductase n=1 Tax=Brevibacterium linens BL2 RepID=UPI0001BC2D4C Length = 825 Score = 307 bits (787), Expect = 3e-82, Method: Composition-based stats. Identities = 115/333 (34%), Positives = 171/333 (51%), Gaps = 30/333 (9%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 +R+ TR+S LA Q+ + +L A+ G VE+V +VT GDV + +PL GG G+ Sbjct: 475 SGRTIRLGTRRSKLARSQSTAIAHQL-AALTGWRVEIVEVVTEGDVNM-SPLTGFGGTGV 532 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FV + AL + + DIAVHS+KD+P G+ + I R DP D + + S LPA Sbjct: 533 FVSAVRQALHQGKIDIAVHSLKDLPTTPEAGIQMAAIPPRVDPADVLIGRDGLSFAELPA 592 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 GS+VGT S RR QL RPD+ +R +RGNV TR++ + +G DA++LA AG++R+G + Sbjct: 593 GSVVGTGSPRRAVQLRAARPDIEVRGVRGNVDTRIAHVRDGRLDAVVLAAAGVRRIGRLA 652 Query: 182 RIRAALPPEISLPAVGQGAVGIECR-------------LDDSRTRELLAALNHHETALRV 228 +L + LPA GQGA+ +E R D+ R L L+ T L V Sbjct: 653 EATDSLDFDTMLPAPGQGALAVETRGADSPFALDNEVMEADAEVRTQLKRLHDETTDLAV 712 Query: 229 TAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER------------ 276 T ERA+ +R E GC PIG+ A + + + A++ DG + Sbjct: 713 TCERAILSRAEAGCSAPIGALATIQGSDFVVDAVMADDDGKLARTRQVAPLPTTPDVDLD 772 Query: 277 RGAPQDAEQMGIS---LAEELLNNGAREILAEV 306 G+ G LA+EL A ++L ++ Sbjct: 773 SGSANQLSITGKELARLADELGTAAAEDLLGQL 805 >UniRef50_Q6AHF1 Porphobilinogen deaminase n=5 Tax=Actinobacteria (class) RepID=HEM3_LEIXX Length = 329 Score = 304 bits (780), Expect = 2e-81, Method: Composition-based stats. Identities = 115/311 (36%), Positives = 159/311 (51%), Gaps = 15/311 (4%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LR+ TR SPLA+ Q V + + G +ELV + T GD ++ L+++GG G+F Sbjct: 14 ALRVGTRGSPLAVAQTQAVSAAVARA-TGFDIELVTVTTHGDTSRES-LSELGGTGVFAT 71 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L AL D+ VHS+KD+P GL L + +R D RD + + LP G+ Sbjct: 72 ALRDALRNGECDLVVHSLKDLPTAPAPGLVLGAVPKRADARDTLCARDGLRFGELPEGAS 131 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGT S RR QL +RP L I +RGNV TRLS++ G+ DA++LA AGL RLG Sbjct: 132 VGTGSPRRAAQLRAQRPGLDIVDIRGNVDTRLSRVSAGDLDAVVLAAAGLGRLGRLDAAT 191 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSR----TRELLAALNHHETALRVTAERAMNTRLEG 240 A GQGA+ +E R D R LAA++H T TAERA+ LE Sbjct: 192 DFFSLSTMPTAPGQGALALEVREGDERGRGPIARALAAVDHATTCAATTAERAVLAGLEA 251 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---------AEQMGISLA 291 GC P+G+ A + DG ++L A V PDG+ + P A +G + Sbjct: 252 GCAAPVGATAMIDDGLLFLTATVYRPDGAAQLTASHAATPDSFGAAHLDEAARDVGERVV 311 Query: 292 EELLNNGAREI 302 ELL +GA ++ Sbjct: 312 AELLASGAADL 322 >UniRef50_C6V4N6 Porphobilinogen deaminase n=2 Tax=Neorickettsia RepID=C6V4N6_NEORI Length = 286 Score = 304 bits (780), Expect = 2e-81, Method: Composition-based stats. Identities = 113/292 (38%), Positives = 163/292 (55%), Gaps = 9/292 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L++ R S LAL QA V+ L + LV + T GD++ D PL +VGGK LF+KE Sbjct: 4 LKVGARCSTLALAQARLVERALAPYCERID--LVGVRTSGDILSDIPLTEVGGKALFLKE 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE LL DIAVHSMKDVP + L +V + +R P D FVS Y ++ +LP+G+++ Sbjct: 62 LEEKLLTGEIDIAVHSMKDVPAFYHDDLEVVPVLKRAIPNDVFVSFRYPNMLSLPSGAVI 121 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT + RR QL +R + LRGN+ TR+ K N D IILA GL+RLGL I Sbjct: 122 GTCAPRRVVQLNQRF---RVIPLRGNIATRVEKAKN--LDGIILAFCGLERLGLCKMISE 176 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 + ++ LP V QGA+ +E R D REL+ ++ ET + TAERA + G C+ Sbjct: 177 VIHEDVMLPGVAQGALCVEFRKKDHFLRELILNISDRETIICTTAERAFLEEINGDCKTA 236 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 +G+ A + + ++ ++G + R G+ +A+Q+G S A LL Sbjct: 237 LGALAVVKNNTLYFTGMLGKDNRPCYFRTS--GSCLNAKQIGRSAALALLRM 286 >UniRef50_C9RPT6 Porphobilinogen deaminase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RPT6_FIBSS Length = 351 Score = 303 bits (777), Expect = 5e-81, Method: Composition-based stats. Identities = 130/346 (37%), Positives = 172/346 (49%), Gaps = 57/346 (16%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHP-------------GLVVELVPMVTRGDV 47 M D LRIATR+S LAL Q D ++A++ L ELV M T GD Sbjct: 1 MSDLKLRIATRKSALALAQTTMAADAIVAANSVIGNAADSNNARDSLTYELVSMTTEGDR 60 Query: 48 ILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDA 107 LD LA GGKG+F+KELE+ALLE RADIA+HS+KD+P E L + +REDPRDA Sbjct: 61 RLDKSLASFGGKGVFIKELEIALLEGRADIAIHSLKDMPAEVLPQFKLAAVLKREDPRDA 120 Query: 108 FVSNNYD---SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY 164 F+S LPAG+ VGT S+RR QL RPDL +RGN+ TR+ KL E Sbjct: 121 FLSRGGSAGIRFMDLPAGARVGTGSIRRVVQLKALRPDLEYVPIRGNIQTRIGKLA--EL 178 Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLD----------DSRTRE 214 D ++LA AGLKR+GL ++ E LPA GQG + IE D + + Sbjct: 179 DGVVLAAAGLKRMGLADQVTEYFSTEQMLPASGQGILAIETLNDATVQESRVTGRADLAQ 238 Query: 215 LLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELI--DG----------------- 255 +LA +N T +AE A L GCQ P+ S+AE + DG Sbjct: 239 ILARVNDVATYCIASAEMAYLKALNAGCQFPVASFAEFVCEDGIENRGTCGALEENANRI 298 Query: 256 --EIWLRALVGAPDGSQIIRGERRGAPQ--------DAEQMGISLA 291 + +R + +++R E G ++ +GI LA Sbjct: 299 AQTLKIRGIYWDEKSEKLLRAEVAGNVDLNSEDCVQQSKNLGIELA 344 >UniRef50_Q6L2G8 Probable porphobilinogen deaminase n=1 Tax=Picrophilus torridus RepID=HEM3_PICTO Length = 282 Score = 303 bits (777), Expect = 5e-81, Method: Composition-based stats. Identities = 105/255 (41%), Positives = 151/255 (59%), Gaps = 8/255 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LA+ QA VKD+L + G+ E+ ++GD+ LD+PL +GG G+FV + Sbjct: 3 IRIGTRSSKLAMIQAMMVKDRLDSL--GIETEVKGFTSKGDINLDSPLYSIGGTGVFVDD 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L +L+N DIAVHS KD+P L + + +R+DPRD +S + SL+ L A S++ Sbjct: 61 LNRMILKNEIDIAVHSAKDIPSFIDDSLEISAVLKRDDPRDVLISQH--SLNDLEASSVI 118 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR +L R D++I+ LRGN+ TRL KLDNG+YD II+A A R+ + R Sbjct: 119 GTSSLRRIKELKTLRNDILIKDLRGNIDTRLKKLDNGDYDGIIMAKAAYDRMRINRR-HF 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L + +PA QG + I DS ++L +N ET + AER + + L GC P Sbjct: 178 ILNYDDFVPAPNQGIIAI-ISKKDSEINDVLKKINDDETYNDMKAERLILSGLNLGCSKP 236 Query: 246 IGSYAELIDGEIWLR 260 +G YA I++R Sbjct: 237 VGIYAH--KNRIFMR 249 >UniRef50_A8PWJ5 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8PWJ5_MALGO Length = 530 Score = 303 bits (776), Expect = 7e-81, Method: Composition-based stats. Identities = 132/394 (33%), Positives = 188/394 (47%), Gaps = 92/394 (23%) Query: 5 VLRIATRQSPLALWQAHYV------------------------------KDKLMASHPG- 33 L +++R+S LA+ QA V + L P Sbjct: 89 TLVLSSRKSELAVRQATQVQMLLDTRYGRASPVFAPGADQWPSTEVANIRAFLRTFSPDQ 148 Query: 34 -----LVVELVPMVTRGDVILDTPLAKVGGKG--LFVKELEVALLENRADIAVHSMKDVP 86 + + M T GD L +PL +GG+G ++ KELEVAL+ D VHS+KDVP Sbjct: 149 KDVRPVDFPVRTMATLGDQNLKSPLYVIGGEGRAIWTKELEVALMAGGVDAIVHSLKDVP 208 Query: 87 VEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALPAGSIVGTSSLRRQCQLAERRPDL 143 P G+ L I EREDPRDA V Y SL +P GS++GTSS+RR L P L Sbjct: 209 TTMPDGVELAAILEREDPRDALVVKENLPYKSLQEMPQGSVIGTSSVRRVSLLRRAYPHL 268 Query: 144 IIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAV 201 + +RGN+ TRL+KLD +G Y A++LA AGLKR+ LE RI A + + L AVGQG++ Sbjct: 269 MFSDVRGNINTRLAKLDAADGPYTALVLAAAGLKRMDLEHRITAYVSEPVMLHAVGQGSL 328 Query: 202 GIECR-------LDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID 254 IE R D R R ++ ++++ R AERA+ R+EGGC +P+G D Sbjct: 329 AIEVRTPRGESAERDERIRRMIRSISNWRATWRCVAERALMHRMEGGCSIPLGVSTRFED 388 Query: 255 GE--------------------------------------IWLRALVGAPDGSQIIRGER 276 + + A++ + DG+++ + Sbjct: 389 HADIEGLLNERNETPSEMASAGISRPDIRIAHEPPPQGSFLTMAAVIVSLDGTRMCKHSH 448 Query: 277 RG---APQDAEQMGISLAEELL-NNGAREILAEV 306 + +DAEQ+GI +AEEL + AR ILAEV Sbjct: 449 TQLCRSEKDAEQLGILVAEELEHHQNARAILAEV 482 >UniRef50_B2ULP1 Porphobilinogen deaminase n=1 Tax=Akkermansia muciniphila ATCC BAA-835 RepID=B2ULP1_AKKM8 Length = 325 Score = 302 bits (774), Expect = 1e-80, Method: Composition-based stats. Identities = 121/317 (38%), Positives = 157/317 (49%), Gaps = 21/317 (6%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG---- 57 N L I TR S LAL QA V+ L +P L V + T GD D PLA V Sbjct: 3 SKNTLIIGTRGSALALAQADMVRAALSLRYPELDVRCEIIHTIGDRRTDVPLADVARVSG 62 Query: 58 --GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS 115 KG+F+KELE AL + R D+AVHS+KDVP E G L + R D ++ D Sbjct: 63 MVDKGIFIKELETALRDGRIDVAVHSLKDVPSELAAGFTLAAVLPRAAVEDVLITKEPDW 122 Query: 116 LDALPAGSIVGTSSLRRQCQLA-ERRPDLIIRSLRGNVGTRLSKL-DNGEYDAIILAVAG 173 + + T S+RR+ L +LRGNV TRL KL ++ +DA+ILA AG Sbjct: 123 NGS----GTLATGSVRRRLMARTYWGSGLRFENLRGNVPTRLGKLVEHPGWDAVILARAG 178 Query: 174 LKRLGLESRIR---------AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224 L+RLGL + LP E+ +PAVGQG VG+ECR D T E+L +N E+ Sbjct: 179 LERLGLYAPETLVEGRKLYMRPLPVEVFIPAVGQGIVGMECRSSDRETAEMLEGINDPES 238 Query: 225 ALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAE 284 AERA RL C P+G YA E+ LRA P + RG + E Sbjct: 239 FACALAERAFLVRLGANCSTPVGVYAHPDGEELVLRAAYYVPGREEPFAVVIRGDRKAPE 298 Query: 285 QMGISLAEELLNNGARE 301 +G+ EEL +G R+ Sbjct: 299 ALGLRAFEELGLSGWRK 315 >UniRef50_Q5KKQ0 Hydroxymethylbilane synthase, putative n=2 Tax=Filobasidiella neoformans RepID=Q5KKQ0_CRYNE Length = 481 Score = 302 bits (773), Expect = 2e-80, Method: Composition-based stats. Identities = 123/413 (29%), Positives = 169/413 (40%), Gaps = 107/413 (25%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPG-------------------------LVVE 37 N + TR+S LAL Q +V D L H G Sbjct: 30 TNTFILGTRKSNLALVQTGHVADDLRRLHSGAGSKFGETREEGDDAEQGDVPFVHPYTFS 89 Query: 38 LVPMVTRGDVILDTPLAKV-------GGKGLFVKELEVALLENRADIAVHSMKDVPVEFP 90 + M T GD TPL + K L+ ELE L+ D+ VHS+KDVP Sbjct: 90 IESMTTVGDRNQTTPLHLLSPYSSTQPAKSLWTDELEARLINGHFDMLVHSLKDVPTVLK 149 Query: 91 QGLGLVTICEREDPRDAFVSNN---YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRS 147 G + + +R DPRDA V Y L+ LP G++VGT S+RR QL P+L+ Sbjct: 150 DGCEIGCMAKRHDPRDALVVKQGLPYKRLEDLPDGAVVGTGSVRRVAQLKRAFPNLVFED 209 Query: 148 LRGNVGTRLSKLDNGE--YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIEC 205 +RGN+ TR +KLDN + + A+ILA++GL+RLG+ R + L + AVGQGA+ IE Sbjct: 210 MRGNLNTRFNKLDNPQSPFSALILAMSGLERLGMAHRATSPLSSPTLMHAVGQGALAIEI 269 Query: 206 RLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP--------------IGSYAE 251 R D R R L L H +T AER LEGGC VP + ++ E Sbjct: 270 RSTDPRVRNCLRGLGHWQTEWSCGAERGCLRVLEGGCSVPVGVESELVELDEDEVAAHPE 329 Query: 252 LIDG----------------------------------------------------EIWL 259 L++G ++ L Sbjct: 330 LLEGVEDPFKGQEEIPLEGDSPMLWFSGLVDTTSAPTPSTPTFSSHSLPPLRTRLAKLTL 389 Query: 260 RALVGAPDGSQIIRGE----RRGAPQDAEQMGISLAEELLNNGAREILAEVYN 308 + V + DGS+ + + + AEQ G A L GA EIL E+ Sbjct: 390 HSCVTSTDGSKHVLFTPPPVLVRSYRQAEQFGEECARRLRGMGAGEILDEINK 442 >UniRef50_C7DH16 Porphobilinogen deaminase n=1 Tax=Candidatus Micrarchaeum acidiphilum ARMAN-2 RepID=C7DH16_9EURY Length = 301 Score = 301 bits (772), Expect = 2e-80, Method: Composition-based stats. Identities = 107/306 (34%), Positives = 174/306 (56%), Gaps = 7/306 (2%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M ++ + I TR S LA+ QA V++KL A P + +V + T + + D A+ K Sbjct: 1 MSESEITIGTRGSELAVAQAEIVRNKLAAIEPRISFRIVKIKTLNEKV-DRSKART-EKD 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 ++ KE++ A+LE R DIAVHS+KD+ + + + + +R+DPRD F+ N + L Sbjct: 59 IYTKEIDEAILERRIDIAVHSLKDLKFNMDENMQIGAVPDRDDPRDVFIGNTETEFEHLG 118 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 ++VGTSS+RR+ QL P +I L GN+ TRLSKL++GE+ I++A AG+KRLG Sbjct: 119 TDALVGTSSIRRRVQLTRINPKPMISDLHGNIDTRLSKLNSGEFSGIVIAAAGVKRLGKA 178 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R++ ++ +PA+GQGA+ + D+S ELL +++ + + V E Sbjct: 179 VRMQYFDERDV-VPAIGQGAIAVTVHKDNSAAAELLKRIDNMKARVEVGEEIEFGKAFGT 237 Query: 241 GCQVPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GC +PIG+ A++++ G+I + V G +++GE P A G SLAE L+ GA Sbjct: 238 GCNLPIGANAKMLESGKIGIVGFVSDLAGKTLVKGETETGPGHA---GKSLAELLIKKGA 294 Query: 300 REILAE 305 ++ Sbjct: 295 GNLIER 300 >UniRef50_B3LB83 Porphobilinogen deaminase, putative n=1 Tax=Plasmodium knowlesi strain H RepID=B3LB83_PLAKH Length = 449 Score = 301 bits (772), Expect = 2e-80, Method: Composition-based stats. Identities = 101/367 (27%), Positives = 166/367 (45%), Gaps = 73/367 (19%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHP----GLVVELVPMVTRGDVILDTPLAKVGGK 59 + I TR SPLA+ Q+ V+ KL A + + L + T GD ILD + GGK Sbjct: 65 KEIIIGTRDSPLAIKQSEKVRTKLEAYFKKVNKNVKITLKSIKTMGDNILDQKVDLFGGK 124 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 G+F KEL+ L++ + I VHS+KDVP+E P+ + L +R+ DAF+S Y +L+ + Sbjct: 125 GIFTKELDEELIKGKVHICVHSLKDVPMELPEQVQLSCFLKRDTINDAFLSVKYGTLEDM 184 Query: 120 ---------------PAGS------------------------IVGTSSLRRQCQLAERR 140 P G +GTSSLRR Q+ + Sbjct: 185 NKMKMANKMEEGSYQPKGMSQRVINQNVKRDNYEGDHYDNFIPTIGTSSLRRSSQIKYKY 244 Query: 141 PDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAA-------------- 186 ++ ++++RGN+ TR++KL NG+YDAII+A GL+RL + IR Sbjct: 245 KNVAVKNMRGNINTRIAKLCNGQYDAIIIAKCGLERLTTKKGIRNIIGGKNKVTPKNFLI 304 Query: 187 ----------------LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTA 230 + PA+ QG + + D ++L +N + + Sbjct: 305 NYNNTEINLTSLHIQQINKRTIYPALCQGIIAVSSHKSDKYISDVLKNINDEKAQIMANI 364 Query: 231 ERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISL 290 ER+ ++EG C +PIG YA++++GEI A++ G + G + ++ + Sbjct: 365 ERSFLYQIEGNCMMPIGGYAKIVNGEIVFNAVINDIHGREKYHVREVGKVESYNEIAVMA 424 Query: 291 AEELLNN 297 A ++ Sbjct: 425 ATKMKEK 431 >UniRef50_D1B7N1 Porphobilinogen deaminase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B7N1_THEAS Length = 307 Score = 299 bits (767), Expect = 8e-80, Method: Composition-based stats. Identities = 114/298 (38%), Positives = 159/298 (53%), Gaps = 12/298 (4%) Query: 10 TRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVA 69 TR SPLA+ QA KD++ + G V L+ + T GD LA GG G FVK LE Sbjct: 8 TRSSPLAMAQARMWKDRIESL--GHSVRLLDVSTHGDRDRRRHLACFGGFGAFVKALEDR 65 Query: 70 LLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSS 129 LL + AVHS+KDVP P GL + + ER D V+ SL+ LP+G+++GTSS Sbjct: 66 LLSGQGHGAVHSLKDVPSVQPDGLVIAGVLERGPRGDVLVTREGLSLEELPSGAVIGTSS 125 Query: 130 LRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPP 189 +RR Q+ R DL + RGNV +RL KL+ G + I+LA AGL+RLG IRA + Sbjct: 126 IRRAAQVRMLRGDLNVECCRGNVHSRLRKLEQGLFHGIVLARAGLERLG----IRAPMAE 181 Query: 190 EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSY 249 + + GQGAV +E R S L A L H T L V AER+ GC P+ + Sbjct: 182 LPFITSPGQGAVALEAREG-SELHLLGARLTHRSTWLEVLAERSFLKAFGMGCSAPVAAS 240 Query: 250 AELIDGEIWLRALVGAPDGSQIIRGERRGAP---QDAEQMGISLAEELLNNGAREILA 304 A + + L+ V +P+G+ E P +DA +G + E+ +G+ E+L+ Sbjct: 241 AVMDRDTLTLKVQVLSPNGTSAAEAEVSCVPWGEEDAYALGEAAFREI--SGSPEVLS 296 >UniRef50_A6LKX0 Porphobilinogen deaminase n=1 Tax=Thermosipho melanesiensis BI429 RepID=A6LKX0_THEM4 Length = 279 Score = 299 bits (766), Expect = 9e-80, Method: Composition-based stats. Identities = 94/246 (38%), Positives = 141/246 (57%), Gaps = 6/246 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +R+ TR+S LAL Q V +KL P + E+ P+VT+GD L TP+ K+GGKG+FV + Sbjct: 3 IRVGTRKSKLALIQTQLVVNKLKELLPNIDFEITPVVTKGDR-LKTPIDKIGGKGVFVSD 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E +L+++ DIA+HSMKD+P + P L L ++ +RE P D F+ + L G+ + Sbjct: 62 IEKLILDDKLDIAIHSMKDLPSKIPDKLFLTSVLKRECPNDVFIGKE--NFFNLKKGAKI 119 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS RR Q+ RPD+ I +RGNV TR+ K+ GE D I++A AG+ RLGL+ +I Sbjct: 120 GTSSKRRALQINMLRPDIEIVPIRGNVDTRIKKI--GELDGIVIAAAGVIRLGLKDKITN 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSR-TRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 E +PA QG + +E + E+ + +T + ER + + L C Sbjct: 178 LFEFEKIVPAPCQGILALEFSEKFLKPFEEIKDVIVDPKTEVETQIERKILSLLNFDCNT 237 Query: 245 PIGSYA 250 P G Y Sbjct: 238 PFGFYC 243 >UniRef50_A2SQU4 Uroporphyrin-III C-methyltransferase n=11 Tax=Euryarchaeota RepID=A2SQU4_METLZ Length = 542 Score = 298 bits (765), Expect = 1e-79, Method: Composition-based stats. Identities = 119/308 (38%), Positives = 165/308 (53%), Gaps = 22/308 (7%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 + +RI TR S LAL Q V L + G+ E V + T GD + D L ++GG G+FV Sbjct: 2 SKIRIGTRGSKLALAQTKKVIGLLAEN--GIDAEYVIIKTTGDKVTDRGLHQIGGFGMFV 59 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 +EL+ A+L D AVHSMKD+P E P+GL V + +R+ P D V N ++ L Sbjct: 60 RELDNAILRGEIDCAVHSMKDIPAERPKGLLTVAVLKRDPPYDFLVMNG--KVEDL---M 114 Query: 124 IVGTSSLRRQCQLAERR---PDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 ++GTSSLRR+ QL P + + LRGN+ TRL KLD+G YD I++A AGL RL + Sbjct: 115 VIGTSSLRRKAQLLRYFHNCPAVRVEMLRGNLDTRLGKLDDGLYDGIMVAEAGLMRLDYK 174 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R L P++ +PA QG + I R D R A LN ++AL ER + ++ G Sbjct: 175 -RNGVRLSPDMFVPAANQGTIAIVSR-DTPELRAAFAPLNDPQSALDCAIERIVMEQVGG 232 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-GAPQDAEQMGISLAEELLNNGA 299 GC P+G + E L A V + DG++ R G + A GI L N GA Sbjct: 233 GCFTPMGIFCENQ----HLTAEVLSLDGTRAERITAEIGDLEGARVAGI----RLKNVGA 284 Query: 300 REILAEVY 307 E++AE Sbjct: 285 -ELIAEAK 291 >UniRef50_C5EV71 Pyruvate ferredoxin/flavodoxin oxidoreductase n=3 Tax=Clostridiales RepID=C5EV71_9FIRM Length = 301 Score = 298 bits (764), Expect = 2e-79, Method: Composition-based stats. Identities = 119/305 (39%), Positives = 165/305 (54%), Gaps = 15/305 (4%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + N++RI TR+S LAL Q H + D L + P + VELV T GD ILD PL + GGKG+ Sbjct: 1 MSNIIRIGTRKSALALIQTHLIADGLKRAWPDIEVELVTKETLGDKILDKPLQEFGGKGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FV E E A+ E D+AVHS KD+P+E +GL + + R DPRD V+ D Sbjct: 61 FVSEFEQAMKEGAIDLAVHSAKDLPMELGEGLVIAAVSGRGDPRDVLVTMKGSPKDR--E 118 Query: 122 GSIVGTSSLRRQCQLAERR-------PDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174 ++GTSS RRQ + E R L +LRGNV TRL KL+ G YD IILA AGL Sbjct: 119 HIVIGTSSPRRQLEAVEYRGQLWPGAASLTCATLRGNVHTRLRKLEEGLYDGIILAAAGL 178 Query: 175 KRLGLESRIRA---ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231 +RL L L P + +PA GQG + +E R S L A++ E L +T E Sbjct: 179 ERLDLLGNPSYDFKYLDPTVFIPAGGQGIMAVEAREG-SDAARLCQAIDSREGRLCLTLE 237 Query: 232 RAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDG-SQIIRGERRGAPQDAEQMGISL 290 R + L+ GC PIG Y+ ++DG++ + + PD ++ I E ++ E + + Sbjct: 238 RMVLKLLDAGCHEPIGIYSNIMDGKMEVWG-ISRPDRVTRRISLEGAVTEKELEALALQA 296 Query: 291 AEELL 295 L+ Sbjct: 297 GRGLM 301 >UniRef50_A3VPD5 Porphobilinogen deaminase n=1 Tax=Parvularcula bermudensis HTCC2503 RepID=A3VPD5_9PROT Length = 324 Score = 298 bits (763), Expect = 2e-79, Method: Composition-based stats. Identities = 135/286 (47%), Positives = 178/286 (62%), Gaps = 6/286 (2%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMAS------HPGLVVELVPMVTRGDVILDTPLA 54 M LRIA+R+SPLA+ QA +V+D+L + VT GD +L+ LA Sbjct: 1 MSFKPLRIASRRSPLAVAQALWVRDRLAEALGIDEVDRDAAFPHETFVTTGDRMLNPTLA 60 Query: 55 KVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD 114 +GGKGLF KE+E+ALL+ +ADIAVHSMKD+P + P GL L + REDPRDAFV+ + Sbjct: 61 DIGGKGLFTKEIEIALLDGQADIAVHSMKDMPAQMPPGLVLAAVPVREDPRDAFVTLDGR 120 Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174 LD +PAG+ +GTSS RR+ QLA RPDL + +RGNVGTRL KL GE + LA AGL Sbjct: 121 PLDQMPAGARIGTSSTRRRAQLARLRPDLALVPMRGNVGTRLQKLAAGEAEGTFLAEAGL 180 Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234 +RLG+ R AL P LPA+GQGA+ ++ R D T A +N+ TAL AERA+ Sbjct: 181 RRLGMTDVKREALSPARMLPALGQGALCVQARSGDHETLSACAHINNRPTALAAAAERAL 240 Query: 235 NTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAP 280 + L+G C+ PIG A + L + PDG +++RGER A Sbjct: 241 ISGLDGSCKTPIGGLARQTGDSLILEGQILTPDGRRVLRGERTVAI 286 >UniRef50_Q1AUK3 Porphobilinogen deaminase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=HEM3_RUBXD Length = 305 Score = 297 bits (761), Expect = 4e-79, Method: Composition-based stats. Identities = 133/302 (44%), Positives = 174/302 (57%), Gaps = 5/302 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + L + TR SPLAL QA L A+ G VEL + T D D PL+ + + + Sbjct: 1 MAGRLVLGTRGSPLALAQAEACAAGLRAA--GFAVELRRIRTTSDRRPDDPLSVIDQRDV 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F ++L+ ALL D+AVHSMKDVP E P+G+ L + R DP DA VS +D LP Sbjct: 59 FTRQLDEALLAGEVDLAVHSMKDVPTEVPEGIVLAAVAGRADPSDALVSEGGWGVDGLPE 118 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ V TSSLRR+ QL RRPDL + +RGNV TR+ K+ G +A++LA AGL RLGLE Sbjct: 119 GARVATSSLRRRAQLLHRRPDLRVVEIRGNVDTRIRKMRAGAAEAVVLARAGLVRLGLEV 178 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 A +P ++ LPAVGQGA+ + R D R E+ ALN V AERA+ LEGG Sbjct: 179 P-HAVIPHDVLLPAVGQGALAVAVRRGDPRLEEIRRALNDPAAEREVAAERALLRALEGG 237 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 C+VP+G+ A + LR +V +PDG+ + GE RG + LA LL GA Sbjct: 238 CRVPVGARAVAGGRGVLLRGVVVSPDGAALCGGEERGEEPEEVG--RRLAARLLERGAAG 295 Query: 302 IL 303 IL Sbjct: 296 IL 297 >UniRef50_C3MZR8 Probable porphobilinogen deaminase n=11 Tax=Sulfolobus RepID=HEM3_SULIA Length = 293 Score = 297 bits (761), Expect = 4e-79, Method: Composition-based stats. Identities = 97/292 (33%), Positives = 148/292 (50%), Gaps = 9/292 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RIA R S L+ Q + +KL G+ E++ + T+ D+ PL+K+G KG+F KE Sbjct: 3 IRIAARGSKLSRIQVDMLGEKLKKI--GIEYEIIDIKTKADLFSTEPLSKLG-KGVFEKE 59 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 + A+LE +ADIAVHSMKD+ E L + + ER+ P D ++ +LD L + + Sbjct: 60 VNEAVLEGKADIAVHSMKDILSEINPSLEIFAVLERDPPYDILIAEK--NLDKLDSNITI 117 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR+ L +P++ + +RGNV TR+ K + EY +ILA A LKRL + Sbjct: 118 GTSSIRRKNFLKYIKPEINTKDIRGNVDTRIRKYLSKEYQGLILAEASLKRLNMTMNYHR 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 + P QG + R D + +E+ +NH +T AERA+ + + GGC P Sbjct: 178 LNVYD-FTPEANQGIIVALGRKKDEKIKEIFKEINHKDTLDEALAERAVISLVGGGCHSP 236 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 IG + E + + DG + I P D +G L L Sbjct: 237 IGVLFKKEGKEFY--GIASYSDGKKKITVSIS-KPGDPYTIGSELGLLLKKE 285 >UniRef50_C7M2H5 Porphobilinogen deaminase n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7M2H5_ACIFD Length = 291 Score = 296 bits (758), Expect = 8e-79, Method: Composition-based stats. Identities = 123/299 (41%), Positives = 171/299 (57%), Gaps = 14/299 (4%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +RIATR+S LA WQA V ++L ELV + T GD + LA++GG+G+FVK Sbjct: 3 PVRIATRRSALARWQASLVGERLGRY------ELVEVHTAGDRDQASSLAEIGGQGVFVK 56 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E++ A++ ADIAVHS KD+P L L + ER D RDA V L+ L G+ Sbjct: 57 EVQAAVVRGEADIAVHSAKDLPTAAGP-LLLAAVLERADARDAIV---GARLEELAIGAR 112 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGTS+ RR QL RPDL + S+RGN+ TRL ++ GE DAI++AVA L+RLGLE Sbjct: 113 VGTSAPRRAAQLRLLRPDLEVVSIRGNIATRLGRV--GELDAIVMAVAALERLGLEEPPW 170 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 LP E+ P GQGA+ +EC D E L +L+ + + AERA+ GC + Sbjct: 171 WPLPEEVLCPQAGQGAIAVECAPDADGLIERLRSLDDDRSRREIEAERAVLAAFGTGCAL 230 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 P+G+ A + LRA+ PDG++ + ER G D +G ++AE L GA ++ Sbjct: 231 PLGARAHADGSSLRLRAVAVDPDGTRQLEVEREGV--DPATLGATVAEVLRRLGADALV 287 >UniRef50_C7R376 Porphobilinogen deaminase n=1 Tax=Jonesia denitrificans DSM 20603 RepID=C7R376_JONDD Length = 344 Score = 295 bits (756), Expect = 1e-78, Method: Composition-based stats. Identities = 126/344 (36%), Positives = 172/344 (50%), Gaps = 47/344 (13%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LR+ TR S LA Q+ L+A G+ V+L + T GD +L LA +GG G+FV Sbjct: 4 LRLGTRASALATAQSRATA-ALIAQATGVTVDLTHIRTDGD-VLTGSLATMGGAGVFVTA 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 + ALL DIAVHS+KD+P +G ++ + ERE+P+DA S + +SL LP G++V Sbjct: 62 IRQALLAGDIDIAVHSLKDLPTTPHEGTTII-VPERENPQDALCSRHGESLAHLPHGALV 120 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD---------NGEYDAIILAVAGLKR 176 GT S RR QL RPDL I +RGNV TRL+++ + DA++LA AGL+R Sbjct: 121 GTGSPRRAAQLLVARPDLRIVDIRGNVDTRLARVGLSTADKPHIRNDLDAVVLAAAGLRR 180 Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSR----TRELLAALNHHETALRVTAER 232 LG I LPP LPA GQGA+ IE R D + + L+H TA V AER Sbjct: 181 LGRAHVISELLPPTSMLPAPGQGALAIEVRHDMADHHPSILAGIRTLHHQPTAYAVAAER 240 Query: 233 AMNTRLEGGCQVPIGSYAEL-----------IDGEIWLRALVGAPDGSQII--------- 272 A+ LE GC P+G+ A + +D + A P + I Sbjct: 241 AVLRHLEAGCAAPVGALATMHNTTLTLTATALDPRLTPTAHTPTPSTTTDINAAPTPMTA 300 Query: 273 -----------RGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 + DA + GI+LA LL +GA E L + Sbjct: 301 PADARPPIRLTHTHTVTSENDATEAGITLATTLLTHGAAEFLRD 344 >UniRef50_Q0ATQ1 Porphobilinogen deaminase n=3 Tax=Alphaproteobacteria RepID=Q0ATQ1_MARMM Length = 321 Score = 294 bits (754), Expect = 2e-78, Method: Composition-based stats. Identities = 129/305 (42%), Positives = 165/305 (54%), Gaps = 14/305 (4%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMA------SHPGLVVELVPMVTRGDVILDTPLAKV 56 L IATR+SPLAL QA V+ KL A ++ +V+ GD I D L + Sbjct: 5 SRPLAIATRRSPLALVQARDVQAKLAAQCGLSGEDAERCFPILGLVSTGDRIQDRTLIEA 64 Query: 57 GGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS- 115 GGKGLF KE++ A L+ RA AVHSMKDVP P G+ L + EREDPRD ++ + ++ Sbjct: 65 GGKGLFTKEIDEAQLDGRAAFAVHSMKDVPTVLPDGIVLGALLEREDPRDMLIARDGETR 124 Query: 116 LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLK 175 L LP G +GT+SLRRQ QL +RPDL + LRGNV TRL KL +G A LA AGL Sbjct: 125 LADLPEGVTIGTASLRRQAQLLHKRPDLHVVPLRGNVDTRLGKLADGGIHATFLARAGLN 184 Query: 176 RLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235 RLG +R L + LPA QGAVG+ R D +A L+H +T L V AERA Sbjct: 185 RLGRAEALRDPLEADEMLPAAAQGAVGVAIRDGDEEAASYVAGLHHRDTELAVLAERAFL 244 Query: 236 TRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-----GAPQDAEQMGISL 290 L+G C+ PI ++ + + V PDG Q R + R P A Q G L Sbjct: 245 FELDGSCRTPIAAHVNKV--SMDFIGEVLTPDGQQSWRRQIRFDMTHATPDSARQAGQDL 302 Query: 291 AEELL 295 + Sbjct: 303 GRAVR 307 >UniRef50_A4YD92 Probable porphobilinogen deaminase n=1 Tax=Metallosphaera sedula DSM 5348 RepID=HEM3_METS5 Length = 290 Score = 294 bits (754), Expect = 3e-78, Method: Composition-based stats. Identities = 110/296 (37%), Positives = 153/296 (51%), Gaps = 14/296 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RIA R S L+L Q V L A G E + + T+ D+ + PL ++G KG+F KE Sbjct: 3 IRIAARGSKLSLKQVEIVTTYLQAK--GYETEFIEIKTKADLFGNKPLHEIG-KGVFEKE 59 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 + A+L+ RADIAVHSMKD+ E P GL L+ +RE+P D VS +L+ LP S + Sbjct: 60 VNEAVLQGRADIAVHSMKDMSSELPPGLELLATPKRENPVDVLVSE--LNLEELPEKSRI 117 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT SLRR L RPDL++ ++RGNV TRL K + EYD IILA AGL+RLG+E + R Sbjct: 118 GTGSLRRANFLKVVRPDLVVENIRGNVDTRLRKYRDHEYDGIILAEAGLRRLGVEVK-RF 176 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L E P QG + + + L LN T AE+ + GGC P Sbjct: 177 PLDVESFTPEPNQGIIAVV---GSPKFLGLFQELNDTGTMKEALAEKETVKVVGGGCHSP 233 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIR---GERRGAPQDAEQMGISLAEELLNNG 298 +G L D L + +G + + R Q+G +L + + + G Sbjct: 234 LGVLFRLEDD--VLHGIASYSNGVKRVTVKLSTRESPQIAGNQLGKALVKAMKDEG 287 >UniRef50_C4JRY9 Porphobilinogen deaminase n=1 Tax=Uncinocarpus reesii 1704 RepID=C4JRY9_UNCRE Length = 287 Score = 294 bits (753), Expect = 3e-78, Method: Composition-based stats. Identities = 107/318 (33%), Positives = 155/318 (48%), Gaps = 58/318 (18%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 I TR+SPLAL Q V+ L ++P Sbjct: 7 KTYTIGTRKSPLALVQTDLVRRALQTAYPN------------------------------ 36 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD---SLDALP 120 D+ VH VP + P L + RE+PRD V +L LP Sbjct: 37 -----------CDLKVHG--HVPTQIPDACVLGAMMPRENPRDVLVIKKGLPWMTLAELP 83 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLKRLG 178 AGS+VGTSS+RR QLA P L+++ +RGN+ TRL+KLD +G + +I+A AGL R G Sbjct: 84 AGSVVGTSSVRRTAQLARHYPHLVVQDIRGNIDTRLAKLDAEDGPFTCLIMAAAGLLRTG 143 Query: 179 LESRIRAALPPE--ISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236 E+R+ L + L AVGQGA+GIE R DD ++++ + T AER + Sbjct: 144 HENRVTQYLDSKNGKMLHAVGQGALGIEVRTDDEVMKDMVNKIGDMPTTYACMAERNLLR 203 Query: 237 RLEGGCQVPIGSYAELIDGE-----IWLRALVGAPDGSQIIRGERRG---APQDAEQMGI 288 +EGGC P+G E I + + LRA+V + DG + + E+ G + ++AE G Sbjct: 204 TVEGGCSAPLGVETEWIQDDNGKSLLRLRAIVVSVDGKEAVELEKDGDVESIEEAEAFGK 263 Query: 289 SLAEELLNNGAREILAEV 306 +A EL++ GA +IL E+ Sbjct: 264 QVALELIDKGAGKILEEI 281 >UniRef50_D1JID7 Porphobilinogen deaminase n=1 Tax=uncultured archaeon RepID=D1JID7_9ARCH Length = 290 Score = 291 bits (747), Expect = 2e-77, Method: Composition-based stats. Identities = 98/295 (33%), Positives = 154/295 (52%), Gaps = 11/295 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 + + TR S LAL Q V ++L G+ E+ + + GDV+ D L ++ G+FVK+ Sbjct: 1 MIVGTRGSNLALVQTKKVCERLSEL--GVECEIKTVQSLGDVMTDRGLYEMPTIGVFVKK 58 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L++ LL+ + DIAVHSMKD+P E + L + R+ P DA VS LD +P G+++ Sbjct: 59 LDMMLLDAKIDIAVHSMKDMPSEREEELDTSAVLPRDSPYDALVSRY--RLDDMPEGAVI 116 Query: 126 GTSSLRRQCQLAE----RRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 GTSS+RR+ Q R + I+ +RGNV TR++K GEYD++ILA AG +RL L+ Sbjct: 117 GTSSVRRRYQFLNYVGERGVKVTIKDIRGNVDTRIAKFRRGEYDSVILAEAGFERLKLDI 176 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 L + +P+ QG + + R E+L ++ ET + E + + GG Sbjct: 177 E-YERLDRDPFVPSPRQGIIAVVARRGSKE-SEILKQIDDSETRIEAEVEEEVLKVIGGG 234 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 C +P+G +A G + L V A D + G E+ LA++ + Sbjct: 235 CSLPVGVHATAKGGSVELAVYVAASDVRYKLEKVVLGKDYYMEET-RELAQKFKS 288 >UniRef50_A9HK97 Porphobilinogen deaminase n=12 Tax=Acetobacteraceae RepID=A9HK97_GLUDA Length = 367 Score = 291 bits (745), Expect = 3e-77, Method: Composition-based stats. Identities = 134/321 (41%), Positives = 171/321 (53%), Gaps = 21/321 (6%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLV----VELVPMVTRGDVILDTPLAKVGGKG 60 LR+ TR SPLAL Q L P L + + T GD + + LA++GGKG Sbjct: 46 PLRVGTRASPLALVQTRAFLTMLTRFCPVLRDMGAFQEHQINTTGDQVQNRRLAEIGGKG 105 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY------- 113 LF KE+ AL + R D AVHS+KD+ P GL L RED RDA + Sbjct: 106 LFAKEIHDALSDGRIDFAVHSLKDLETTLPPGLVLACTLRREDARDALILGPGAGGRHDA 165 Query: 114 ----DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIIL 169 D ALP ++VG +S+RRQ Q+ RPDL LRGNV TRL KL + DA +L Sbjct: 166 ADAADPYAALPRNALVGCASVRRQAQMLHVRPDLRFGLLRGNVQTRLDKLAARQCDATLL 225 Query: 170 AVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVT 229 A+AGL+RLG+E R L PEI +PA GQG VG+ R D RELLAA+ +E T Sbjct: 226 ALAGLRRLGMEDRADIVLDPEIMVPAAGQGIVGVTVRESDVELRELLAAIEDYEARAVAT 285 Query: 230 AERAMNTRLEGGCQVPIGSYAELIDG------EIWLRALVGAPDGSQIIRGERRGAPQDA 283 AERA+ L+G C+ PIG YA L+ G + L LV DGS ++R G DA Sbjct: 286 AERALLAELDGSCRTPIGGYARLVPGLAGAEASLRLTGLVAREDGSFLLRRTVTGLRADA 345 Query: 284 EQMGISLAEELLNNGAREILA 304 E+MG L L + ++ A Sbjct: 346 EEMGRELGRSLRMDSPSDVFA 366 >UniRef50_B5GJG2 Porphobilinogen deaminase n=3 Tax=Streptomyces RepID=B5GJG2_9ACTO Length = 335 Score = 289 bits (741), Expect = 8e-77, Method: Composition-based stats. Identities = 113/308 (36%), Positives = 153/308 (49%), Gaps = 12/308 (3%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTP----LAKVGGK 59 + + +R S LA Q + ++ PG+ + GD TP + + G Sbjct: 31 RTVTVGSRGSALARAQVREMVERWEREVPGVRFVRRVITEAGDADRSTPTVAGVTRRAGV 90 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTIC-EREDPRDAFVSNNYDSLDA 118 F E AL+ D+ VH +KD+P G L+ RED RDA +L Sbjct: 91 SAFSSRQEAALVRREVDVVVHCLKDLPTTPAPGTALLRTPGPREDARDALC---GATLAG 147 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 LP G+ VGT S RR QL RPDL + +RGNV RL++L DA++LA AGL RLG Sbjct: 148 LPRGARVGTGSTRRVAQLLALRPDLEVIPVRGNVPARLARLRT--LDAVVLAAAGLHRLG 205 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 L I L PE PA GQGA+ I+ R S LLAA T V AER + L Sbjct: 206 LTEEITEYLDPEAYPPAPGQGALAIQVREG-SGAARLLAASGDPATDTEVRAERVLLAEL 264 Query: 239 EGGCQVPIGSY-AELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 GGC VP+G++ + G + L A V APDG + I +G + +++ +++AE LL Sbjct: 265 HGGCSVPLGTWTSRPSPGTLRLHAAVTAPDGGRQITATAQGPASEPDKLALTVAERLLAG 324 Query: 298 GAREILAE 305 GA ILAE Sbjct: 325 GAARILAE 332 >UniRef50_Q2FTK7 Hydroxymethylbilane synthase n=3 Tax=Methanomicrobiales RepID=Q2FTK7_METHJ Length = 295 Score = 289 bits (741), Expect = 8e-77, Method: Composition-based stats. Identities = 111/305 (36%), Positives = 164/305 (53%), Gaps = 19/305 (6%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LR+ TR S LA QA V L G+ ELV + T GD PL ++GG+G+FV+ Sbjct: 2 PLRVGTRASELAKAQAVKVCTMLEDL--GVDTELVFISTAGDEQTGVPLHEIGGQGVFVR 59 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L+ AL++N+ D+AVHSMKD+P E P GL I R+ P D V+++ L + Sbjct: 60 ALDDALVQNKIDLAVHSMKDIPAERPYGLVTSAILARDSPCDYIVTDH-----ELDEITT 114 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSS RR Q P IR LRGNV TRLSKL +GEYDAI+LA AGL+RL + Sbjct: 115 LGTSSTRRTAQCRRNLPWADIRPLRGNVNTRLSKLQSGEYDAIMLAKAGLERLSMTLDGY 174 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L P + +P+ QG + + R D ++++ ++ +T + ER + + GGC Sbjct: 175 Q-LDPRVHVPSPNQGTIAVVSRT-DPDVTDIISKIDDPKTRMDTLLERRVMEMIGGGCFT 232 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGER-RGAPQDAEQMGISLAEELLNNGAREIL 303 P+G Y + + + A V + +G + R ER DA++ G+ + E A +++ Sbjct: 233 PLGIYCK----DRLMIAEVLSLEGDRHFRLERLVSDIDDADRFGLEVRER-----AGDLI 283 Query: 304 AEVYN 308 E Y Sbjct: 284 REAYE 288 >UniRef50_D2RNT2 Porphobilinogen deaminase n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RNT2_ACIFE Length = 288 Score = 289 bits (741), Expect = 8e-77, Method: Composition-based stats. Identities = 118/297 (39%), Positives = 163/297 (54%), Gaps = 14/297 (4%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L +ATR S LAL Q H V L + G+ E+ + T GD L K+GG+G+FV Sbjct: 2 KKLIVATRGSRLALAQTHIVCRLLEEA--GVETEIRTITTAGDRDRIHALVKIGGRGIFV 59 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 +E+E LL ADIAVHS KD+P + GL + + DPRDA V L+ AGS Sbjct: 60 REIERELLSGEADIAVHSAKDLPYQLASGLVIAGTPSQADPRDALVLLKERKLE---AGS 116 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +VGT S RR +++ P+L+ R +RGNV TRL KL+ GEYDAI+LA+AG++RL L+ Sbjct: 117 VVGTGSPRRIREISRVLPELVFRDIRGNVTTRLHKLERGEYDAIVLAMAGIQRLALDMEQ 176 Query: 184 RAALP--PEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 P E +PA QG +G+ECR D LL ++ ET R ER + T ++ Sbjct: 177 FQIRPLSTEQVIPAGCQGIIGVECRQKDRELVRLLQQISDPETWRRFQWERQLFTSMKVD 236 Query: 242 CQVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 C P+G + L G + L A+V DG R R G ++ + + SL EEL + Sbjct: 237 CSRPVGIHCRLLKSGRMELLAMV---DGK---RARRLGMEKEGKALCASLKEELYDR 287 >UniRef50_C0W553 Porphobilinogen deaminase n=2 Tax=Actinomycetales RepID=C0W553_9ACTO Length = 402 Score = 287 bits (735), Expect = 4e-76, Method: Composition-based stats. Identities = 129/387 (33%), Positives = 176/387 (45%), Gaps = 81/387 (20%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASH----PGLVVELVPMVTRGDVILDTPLAKVGGK 59 + +R+ TR S LAL Q+ V L + L VELVP+ TRGDV T L+++GG Sbjct: 2 STVRLGTRGSALALTQSGLVARMLEQAAALAGQELHVELVPVRTRGDVD-PTALSQLGGV 60 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD-SLDA 118 G+F L ALL D+AVHS KD+P GL + + REDPRD + L Sbjct: 61 GVFATALREALLAGECDLAVHSYKDLPTAAVPGLRIAAVPAREDPRDVLCTRAATLGLHD 120 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--------------DNGEY 164 LPAG+ VGT S RR QL +RPDL I +RGNV TRL+++ + Sbjct: 121 LPAGARVGTGSPRRSAQLLAQRPDLTIVPIRGNVPTRLARVVGSVVSADGPMGATAEPDL 180 Query: 165 DAIILAVAGLKRLGLESRIRAAL---------------------------PPEISLPAVG 197 DA ILA++G++RLGLE L LPA Sbjct: 181 DAAILALSGMRRLGLEDYASQPLAARCGARSQVEVQGIPDGGSAAGSPATTEPWMLPAAA 240 Query: 198 QGAVGIECRLDDSRTREL------LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAE 251 QGA+ +E R D + EL LA ++ T AER++ L GC P+G+ A Sbjct: 241 QGALAVETR--DRVSCELPVLTVALALVDDPVTRACADAERSLMRCLAAGCAAPVGALAR 298 Query: 252 LID--------------------------GEIWLRALVGAPDGSQIIRGERRGAPQDAEQ 285 +D I L ALV + DG+Q+ R G ++AE Sbjct: 299 PLDVAGEPAAGRDLPTEPGTALEPGPDQAPAICLEALVASLDGTQLRRASATGTLEEAED 358 Query: 286 MGISLAEELLNNGAREILAEVYNGDAP 312 +G +AE LL +GA +I + +P Sbjct: 359 LGRCVAERLLADGAAQITDLQASKGSP 385 >UniRef50_C8WDJ7 Porphobilinogen deaminase n=3 Tax=Zymomonas mobilis RepID=C8WDJ7_ZYMMN Length = 308 Score = 286 bits (733), Expect = 6e-76, Method: Composition-based stats. Identities = 116/292 (39%), Positives = 162/292 (55%), Gaps = 7/292 (2%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHP--GLVVELVPMVTRGDVILDTPLAKVGGK 59 + R+ +R SPLAL QA V L A+H V +VP+ T GD LA +GGK Sbjct: 1 MQLPFRLGSRGSPLALIQARSVASALCAAHSWSEDAVVIVPIRTSGDKNRHQALADIGGK 60 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 L+ KEL++AL + D AVHSMKDV P + + + RED D + SL+ L Sbjct: 61 ALWTKELDIALTTGQIDAAVHSMKDVETFRPSHISIAAMLPREDVHDRLIG--IPSLEVL 118 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P VGT+S RR Q+ RPD+ I+ LRGN+ TRL KL N ++DA +LA AGL RLG Sbjct: 119 PYSGCVGTASPRRAAQIRRIRPDIEIKLLRGNIDTRLEKLANKQFDATLLAAAGLIRLGR 178 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 + +P + LPA GQGA+GIE DS E ++ ++H+ T L V +ER + RL Sbjct: 179 ND-VGYDVPLDQMLPAAGQGAIGIEALA-DSAAWEKVSIIDHYPTHLAVQSERQLLLRLN 236 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGA-PQDAEQMGISL 290 C PI +AE+++ I LRA + +G ++ + P DA ++G L Sbjct: 237 ADCHSPIAVFAEILEKNIRLRACLYTENGKFSASIDKEISQPSDAFEVGSLL 288 >UniRef50_Q4PFH9 Putative uncharacterized protein n=1 Tax=Ustilago maydis RepID=Q4PFH9_USTMA Length = 770 Score = 286 bits (733), Expect = 7e-76, Method: Composition-based stats. Identities = 116/294 (39%), Positives = 154/294 (52%), Gaps = 39/294 (13%) Query: 36 VELVPMVTRGDVILDTPLAKVGGKG--LFVKELEVALLENRADIAVHSMKDVPVEFPQGL 93 + M T GD L +PL +GG+G ++ KELEVAL + D VH +KDVP PQGL Sbjct: 251 FPITSMSTAGDQNLRSPLYVIGGEGKAIWTKELEVALEQGAVDAIVHCLKDVPTALPQGL 310 Query: 94 GLVTICEREDPRDAFVSNN---YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRG 150 L + EREDPRDA V Y LD LP GS++GTSS+RR QL R P L+ +RG Sbjct: 311 ELAAVLEREDPRDALVVKAGLPYKVLDELPVGSVIGTSSVRRVAQLRRRYPHLVFSDVRG 370 Query: 151 NVGTRLSKLD--NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRL- 207 N+ TRL+KLD NG Y A+ILA AGL RL + +RI A L + L +VGQG++ IE R Sbjct: 371 NINTRLAKLDAPNGPYTALILAAAGLVRLNMHARITAFLSSPVLLHSVGQGSLAIEVRTP 430 Query: 208 ---------DDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIW 258 D+R REL+ ++ R AER++ LEGGC +P+G D Sbjct: 431 PEGADPTTNRDARIRELIRSIGDWRATFRAEAERSLLKELEGGCSIPVGVETRFDD---- 486 Query: 259 LRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYNGDAP 312 + G +A I+L ++ + G AE+ NG P Sbjct: 487 --------------HDQVEGQRSEA----IALVDDFVTQGNAGAKAELPNGGMP 522 Score = 48.2 bits (114), Expect = 4e-04, Method: Composition-based stats. Identities = 22/58 (37%), Positives = 29/58 (50%), Gaps = 4/58 (6%) Query: 253 IDGEIWLRALVGAPDGSQIIRGERR---GAPQDAEQMGISLAEELL-NNGAREILAEV 306 + L A+V + DGSQ R +DA ++GI +A EL GAR IL EV Sbjct: 600 EGRTLHLDAIVVSLDGSQESRYSASKHCTTVKDARELGIHVAHELAHKKGARAILEEV 657 >UniRef50_B4D5X7 Porphobilinogen deaminase n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4D5X7_9BACT Length = 307 Score = 282 bits (723), Expect = 1e-74, Method: Composition-based stats. Identities = 109/277 (39%), Positives = 151/277 (54%), Gaps = 14/277 (5%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPL---AKVGGKG 60 + + TR S LA+ Q L A+ P + +E VTRGD LD L + GGKG Sbjct: 2 KSIILGTRASALAVAQVELTTKALAAAFPAMQIERREFVTRGDKKLDLSLLRANEAGGKG 61 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF KELE ALL D+AVHS+KD+P P GL + + ER D ++ +L LP Sbjct: 62 LFTKELEDALLNGSIDVAVHSLKDLPGHNPPGLDITAVLERAPTADVLITKQPQTLLDLP 121 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-DNGEYDAIILAVAGLKRLGL 179 G ++GTSS+RR QL RRPD+ + RGNV TRL KL + + IILA AGL+RLG Sbjct: 122 QGVLLGTSSVRRARQLQWRRPDVRVEEWRGNVQTRLRKLAERDDVTGIILAQAGLERLGH 181 Query: 180 E----------SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVT 229 + + E LPA+GQGA+ ++ R D + +L ++H ET L + Sbjct: 182 DLSAGRLETEHGKFYVTSLAEDLLPAIGQGAIALQSRADRAEVAAVLQKIDHRETHLAIR 241 Query: 230 AERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAP 266 AER + L G C +P+G +L+ G I +RA++ P Sbjct: 242 AERELQRLLAGDCALPVGVRTKLLPGGIAMRAILFGP 278 >UniRef50_B5JN62 Porphobilinogen deaminase n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JN62_9BACT Length = 291 Score = 280 bits (718), Expect = 4e-74, Method: Composition-based stats. Identities = 112/290 (38%), Positives = 143/290 (49%), Gaps = 16/290 (5%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67 IATR+SPLA+ Q H K+ P V + MVT GD + L K GGKGLF KELE Sbjct: 10 IATRKSPLAMAQTHLAKELFQRGMPDAVFRIEKMVTTGDKRQEWSLEKQGGKGLFTKELE 69 Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127 ALLE RAD AVHS KD+P E P+GL L R+ D + + L + T Sbjct: 70 DALLEGRADFAVHSAKDLPSEMPKGLALAGFLPRQTCEDVLILRDGVESPKL-----IAT 124 Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG---LESRIR 184 S RR+ QL P +RGNV TRL+K+ G+ DA +LA AGL RLG E Sbjct: 125 GSPRRRIQLRYLFPKAEFTEIRGNVDTRLTKIARGDADATVLASAGLNRLGIESWEGVTF 184 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L + +PAVGQ AV I+CR +D T A ETA+ V ER+ L GGCQV Sbjct: 185 RKLTLDECVPAVGQAAVAIQCREEDVDT---FRAHLDEETAIAVNLERSFLEELGGGCQV 241 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 + G + + G ++ + EQ+ L E+L Sbjct: 242 AFAVN--YVGGRLRI---YHKQCGKEVRDLPQEYVATHYEQIAAKLIEQL 286 >UniRef50_A2BFN7 Hydroxymethylbilane synthase (Fragment) n=6 Tax=Coelomata RepID=A2BFN7_DANRE Length = 247 Score = 279 bits (715), Expect = 8e-74, Method: Composition-based stats. Identities = 112/229 (48%), Positives = 144/229 (62%), Gaps = 4/229 (1%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 V+R+ TR+S LA Q V L +P + +E+V M T GD ILDT L+K+G K LF Sbjct: 19 SRVIRMGTRKSQLARIQTDSVAGTLKQLYPDVHLEIVAMSTIGDKILDTALSKIGEKSLF 78 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDAL 119 KELE AL N DI VHS+KD+P P G + I ERE+P DA V + +LD+L Sbjct: 79 TKELENALERNEVDIVVHSLKDLPTSLPPGFTIGAILERENPHDAVVLHPKNAGLTLDSL 138 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLG 178 P S++GTSSLRR QL +R P L ++RGN+ TRL KLD +Y AIILA AGLKR+G Sbjct: 139 PEKSVIGTSSLRRAAQLKKRFPQLEFENIRGNLNTRLKKLDEKDDYAAIILAAAGLKRMG 198 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALR 227 ESRI L PE + AVGQGA+ +E R D E+++ L+H +T LR Sbjct: 199 WESRISQVLGPEDCMYAVGQGALAVEVRAQDKDILEMVSVLHHPDTVLR 247 >UniRef50_Q97B26 Probable porphobilinogen deaminase n=2 Tax=Thermoplasma RepID=HEM3_THEVO Length = 297 Score = 278 bits (713), Expect = 1e-73, Method: Composition-based stats. Identities = 86/266 (32%), Positives = 136/266 (51%), Gaps = 6/266 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 ++I TR S LA+ QA+ V L A G+ E+V + GD+ P+ +G G+FV++ Sbjct: 3 IKIGTRPSNLAVAQANMVASSLEAI--GIDTEIVKHRSAGDIDTKNPIYSIGKTGVFVQD 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L +L D+AVHS KD+P E L + +R DA VS L +LP + V Sbjct: 61 LNNMILRGEIDVAVHSAKDIPSEIENRLTIAATLKRGSFNDALVSKYD--LRSLPISAKV 118 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR QL R DL ++RGN+ TR++K+ DAI++A A ++RLGL Sbjct: 119 GTSSIRRIFQLKYARQDLKFENIRGNIETRIAKMSELGLDAIVMAEAAIQRLGLNVEYS- 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L +PA QG + + + + + R++L +N T + ER++ +L+ GC P Sbjct: 178 KLDENKFVPAPNQGIIAVVSKKEGT-VRKILEEINDENTFEEMQIERSVVQQLKLGCSTP 236 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQI 271 +G + + A + G + Sbjct: 237 VGILSRPSGKGHKIIAQFFSMQGDDV 262 >UniRef50_Q1GP41 Porphobilinogen deaminase n=7 Tax=Sphingomonadales RepID=HEM3_SPHAL Length = 315 Score = 278 bits (712), Expect = 2e-73, Method: Composition-based stats. Identities = 136/306 (44%), Positives = 172/306 (56%), Gaps = 10/306 (3%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGL--VVELVPMVTRGDVILDTPLAKVGGKG 60 DN LRI TR SPLA+ QAH L+A+H +E+VPM GD I D LA+VGGK Sbjct: 8 DNPLRIGTRASPLAMAQAHMAAAALIAAHGLAMAALEIVPMTATGDRIQDRALAEVGGKA 67 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLD 117 L+ +EL+ AL D+AVHS+KDV L + ER DPRD V + Sbjct: 68 LWTRELDAALDAGTIDVAVHSLKDVETLRDARFFLGAMLERADPRDRLVVREGIAAQKIS 127 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177 LP G+ +GTSS RR Q+ RPDL LRGNV TRL+KL GE DA +LA AGL+RL Sbjct: 128 ELPHGARLGTSSPRRAAQVRRLRPDLDTVLLRGNVATRLAKLAAGEADATLLAAAGLERL 187 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 G+ I A E+ LPA QGA+GIECR DD+ T LLAA++H T V AERA+ Sbjct: 188 GMHD-IGAVQGTELLLPAASQGAIGIECRADDAATIALLAAIDHAPTHRAVAAERALLAV 246 Query: 238 LEGGCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 L G C+ P+ +YAE DG + L A + + DG+ + G DA + +L LL Sbjct: 247 LGGDCRSPVAAYAEWQADGVLRLDAEIFSEDGADHVAGHVIVT--DAGVVA-ALGHRLLA 303 Query: 297 NGAREI 302 I Sbjct: 304 EAPPSI 309 >UniRef50_Q8I5V3 Porphobilinogen deaminase n=6 Tax=Plasmodium RepID=Q8I5V3_PLAF7 Length = 435 Score = 277 bits (710), Expect = 3e-73, Method: Composition-based stats. Identities = 94/356 (26%), Positives = 162/356 (45%), Gaps = 61/356 (17%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHP----GLVVELVPMVTRGDVILD-TPLAKV 56 + + + I TR SPLAL Q+ V+ K+M+ + V + T GD ILD + Sbjct: 58 IKDEIIIGTRDSPLALKQSEKVRKKIMSYFKKMNKNINVTFKYIKTTGDNILDSKSVGLY 117 Query: 57 GGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSL 116 GGKG+F KEL+ L+ D+ VHS+KDVP+ P + L +R+ DAF+S Y S+ Sbjct: 118 GGKGIFTKELDEQLINGNVDLCVHSLKDVPILLPNNIELSCFLKRDTINDAFLSIKYKSI 177 Query: 117 DALPAGS------------------------IVGTSSLRRQCQLAERRPDLIIRSLRGNV 152 + + +GTSSLRR+ Q+ R ++ + ++RGN+ Sbjct: 178 NDMNTVKSVSKTEDIHHINKKDSDHNNDTLCTIGTSSLRRRSQIKNRYKNIYVNNIRGNI 237 Query: 153 GTRLSKLDNGEYDAIILAVAGLKRL--------------------------------GLE 180 TR+ KL NGE DA+I+A+ G++RL L Sbjct: 238 NTRIEKLYNGEVDALIIAMCGIERLIKKANLKHLLKNKEQKNICQPFLLKCNNKKCIDLC 297 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 L + PA+GQG + + + LL +N+ ++ + ER+ ++G Sbjct: 298 HVNIQKLNKNLIYPALGQGIIAVTSHKKNYFISSLLKNINNKKSEMMAQIERSFLYHIDG 357 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 C +PIG Y + + +I+L ++ G + ++ + +++G + A ++ Sbjct: 358 NCMMPIGGYTNMRNEDIYLHVIINDIHGYNKYQVTQKDTLYNYKEIGPNAAIKMKE 413 >UniRef50_C5C5B3 Porphobilinogen deaminase n=6 Tax=Actinomycetales RepID=C5C5B3_BEUC1 Length = 334 Score = 277 bits (709), Expect = 4e-73, Method: Composition-based stats. Identities = 120/294 (40%), Positives = 155/294 (52%), Gaps = 25/294 (8%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHP-----GLVVELVPMVTRGDVILDTPLAKV 56 LR+ TR S LA Q+ + + + A + VELV + T GD +L LA + Sbjct: 18 STRTLRVGTRASALATTQSEWAGEAIAARVAAATGSDVEVELVRVTTTGD-VLTGSLASM 76 Query: 57 GGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSL 116 GG G+FV L ALL+ R D+AVHS+KD+P GL L + +REDPRD + L Sbjct: 77 GGTGVFVTALREALLDGRCDVAVHSLKDLPTAAAPGLVLGAVPQREDPRDVLCARAGAGL 136 Query: 117 DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGL 174 LPAG VGT S RR QL RPDL I +RGNV TRLS++ G+ DA++LA AGL Sbjct: 137 ADLPAGGRVGTGSPRRAAQLRRARPDLEIVDIRGNVDTRLSRISPGKGDLDAVVLARAGL 196 Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECR-LDDSRTRELLAALNHHETALRVTAERA 233 RLG + AL + +PA GQGA+ +E L A + T L VTAERA Sbjct: 197 ARLGRLDAVTEALDAGVMVPAPGQGALAVEAVDAAPDWLLAGLRAFDDAPTRLAVTAERA 256 Query: 234 MNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMG 287 M RLE GC P+G+ A L ++ LR VG +DAE +G Sbjct: 257 MLARLEVGCSAPVGALATLAGSQLLLRTSVG----------------EDAEDLG 294 >UniRef50_Q9Y9J0 Probable porphobilinogen deaminase n=1 Tax=Aeropyrum pernix RepID=HEM3_AERPE Length = 307 Score = 276 bits (708), Expect = 4e-73, Method: Composition-based stats. Identities = 106/294 (36%), Positives = 158/294 (53%), Gaps = 8/294 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVV--ELVPMVTRGDVILDTPLAKVGGKGLFV 63 +R+A R S L+L Q ++L + + G+ + E+V + + GDV D PL +G G+F Sbjct: 3 VRVAARGSRLSLLQVEQALEEL-SRYAGVSMHWEVVRVKSAGDVWSDRPLESIGVVGVFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQG-LGLVTICEREDPRDAFVSNNYD-SLDALPA 121 +E++ A+ ADIAVHS+KD+P G L +V I R RDA +S ++ L Sbjct: 62 REVDRAVASGAADIAVHSLKDMPTSGYGGPLKIVYIASRPSARDALISRQGPGRVEDLEP 121 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 GS +GTSS RR+ P + + +LRGN+ TRL KL G YDAII + AGL RLG++ Sbjct: 122 GSTLGTSSARRRALSLHYNPRIRVENLRGNLDTRLRKLREGLYDAIIASEAGLIRLGVDV 181 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 L P PA GQG V + R+ S ++L L+ AER + G Sbjct: 182 EYT-PLDPSYFPPAPGQGFVAVVARVG-SNVEKMLRDLDKPPWWHVAWAERGVLEGARAG 239 Query: 242 CQVPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 C+ P+ +YAE + + + A +PDGS+ G ++A ++G+SL EEL Sbjct: 240 CRTPVAAYAEPLGRSMVRVTAAALSPDGSRAYWARAEGRIEEARRIGVSLGEEL 293 >UniRef50_C1XV35 Porphobilinogen deaminase n=2 Tax=Meiothermus RepID=C1XV35_9DEIN Length = 304 Score = 275 bits (704), Expect = 1e-72, Method: Composition-based stats. Identities = 114/266 (42%), Positives = 158/266 (59%), Gaps = 10/266 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RIATR S LA WQA +V +L G+ LV + T+GD +++ G+G F K Sbjct: 4 VRIATRGSRLARWQAEWVAAQLQDQ--GIASTLVIVETQGDRER-VAFSQMQGQGFFTKA 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP----- 120 ++ A+ E RAD+AVHS+KD+P GL L I REDPR+A + P Sbjct: 61 VQDAVREGRADLAVHSLKDLPSAPTPGLVLAAIPIREDPREALLVLPSAWDAQAPALPLA 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VG+S++RRQ QLA+ RPDL + LRGNV TR+ KL +G Y+AI+LA AGLKRLGL+ Sbjct: 121 PGARVGSSAVRRQAQLAQLRPDLKLLELRGNVPTRVEKLQSGGYEAILLAWAGLKRLGLD 180 Query: 181 --SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 L P +PA GQGA+ +ECR +D++ R +L L+ L V ER + RL Sbjct: 181 LGGLAVRLLEPREFVPAPGQGALALECREEDTQLRGVLQGLDDPTARLTVGIERGLMARL 240 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVG 264 +GGCQ+ +G+ A+ + G L A G Sbjct: 241 QGGCQLALGASAQRVQGGWQLLAWYG 266 >UniRef50_Q93A65 Porphobilinogen deaminase n=1 Tax=uncultured bacterium RepID=Q93A65_9BACT Length = 299 Score = 273 bits (700), Expect = 4e-72, Method: Composition-based stats. Identities = 115/265 (43%), Positives = 155/265 (58%), Gaps = 11/265 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +R+ATR S LALWQA +V +L+ G VELV + T+GD P A++ G+G F K Sbjct: 4 VRLATRGSRLALWQAEWVAKQLVQQ--GAEVELVVVETQGDR-EKRPFAQMQGQGFFTKA 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN-----NYDSLDALP 120 ++ A+LE RAD AVHS KD+P P GL + + REDPR+ + L Sbjct: 61 VQEAVLEGRADFAVHSYKDLPSARPAGLEIAAVPPREDPRELLLVRLQAVDQVAPGLPLR 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 AG+ VG+S+ RRQ QLA RPDL + LRGNV TR+ KL GEYDA++LA AG++RLGL+ Sbjct: 121 AGARVGSSAARRQAQLAHLRPDLSLLELRGNVLTRVEKLRQGEYDAVLLAYAGVRRLGLD 180 Query: 181 --SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 LPP + +PA QGA+ +ECR DD R R LL L+ +R + RL Sbjct: 181 LSPFHWQVLPPTLLVPAPAQGALALECRQDDKRLRPLLEPLDDPSAGVRCGGA-GLMARL 239 Query: 239 EGGCQVPIGSYAELIDGEIWLRALV 263 GGCQ+ +G+ A+ + L A Sbjct: 240 AGGCQLALGALAQETPEGLQLLAWY 264 >UniRef50_Q0RS16 Porphobilinogen deaminase 1 (PBG 1) (Hydroxymethylbilane synthase 1) (HMBS 1) (Pre-uroporphyrinogen synthase 1) n=2 Tax=Frankia RepID=Q0RS16_FRAAA Length = 402 Score = 273 bits (699), Expect = 5e-72, Method: Composition-based stats. Identities = 121/366 (33%), Positives = 168/366 (45%), Gaps = 77/366 (21%) Query: 13 SPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLE 72 S LAL Q+ + +L G V+LVP+VT GD ++++GG G+FV L ALL Sbjct: 36 SALALTQSGMIAAQLRERV-GCAVDLVPIVTAGDRS-PAEISQIGGTGVFVSALRDALLA 93 Query: 73 NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRR 132 D+AVHS+KD+P P GL L + RED RD VS + L AL G+ V T + RR Sbjct: 94 GEIDLAVHSLKDLPTATPPGLVLAAVPTREDTRDVLVSPSGRGLAALGPGARVATGAPRR 153 Query: 133 QCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEIS 192 QL + ++RGNV TRL K +GE DA++LA AGL RL + L PE+ Sbjct: 154 AAQLRALGLGFDVVAIRGNVDTRLKKAIDGEVDAVVLAYAGLARLDRLDAVTEILDPEVM 213 Query: 193 LPAVGQGAVGIE------------------------------------------------ 204 LPA GQGA+ +E Sbjct: 214 LPAPGQGALAVECAAEAGLRLAGPARALVAAGAGDHADGDRPGAEAGRDGRGRGPDVGRN 273 Query: 205 ---CRLD-----DSRTRELLA-ALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID- 254 R D D ELL L+ +++ + AERA +E GC P+G+ A Sbjct: 274 SGQTRSDHGQPLDGGLAELLRFVLDDASSSVAIRAERAFLAGIEAGCTAPVGALAVAEPA 333 Query: 255 -----------------GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 G + LRA+V APDGS ++R + G+ D E +G LA++LL+ Sbjct: 334 PAAAVGTVAPAGDASPAGRLRLRAVVAAPDGSTVLRRDVTGSAVDPEALGQRLADDLLSA 393 Query: 298 GAREIL 303 GA ++ Sbjct: 394 GAHSLM 399 >UniRef50_B0WMK9 Porphobilinogen deaminase n=1 Tax=Culex quinquefasciatus RepID=B0WMK9_CULQU Length = 474 Score = 273 bits (698), Expect = 8e-72, Method: Composition-based stats. Identities = 96/243 (39%), Positives = 133/243 (54%), Gaps = 29/243 (11%) Query: 13 SPLALWQAHYVKDKLMASHPGLVVELV------------------------PMVTRGDVI 48 S LAL Q YV L +P +V E+ M T GD + Sbjct: 167 SKLALIQTKYVISCLQKLNPDVVYEIRKYFQHVHLCWHVPSYLLAFFLSPDTMTTVGDRV 226 Query: 49 LDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAF 108 L+ L K+G K LF K+LE AL D VHS+KD+P P G+ + + ER+DPRDA Sbjct: 227 LNKSLPKIGEKSLFTKDLEDALRTGGVDFVVHSLKDLPTALPLGMAIGAVLERDDPRDAL 286 Query: 109 V---SNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG--E 163 V ++ +L LP GS+VGTSSLRR QLA + ++++ +RGN+ TRL+KLD + Sbjct: 287 VLNEAHRGRTLSTLPKGSVVGTSSLRRSAQLARKYENVVVCDIRGNLNTRLAKLDADGSK 346 Query: 164 YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHE 223 + IILA AGL R+G +R+ + P L AVGQGA+ +ECR +D ++L+ L H E Sbjct: 347 FAGIILAQAGLVRMGWNARVSQVIEPGEILYAVGQGALAVECRSNDEYILDMLSKLCHLE 406 Query: 224 TAL 226 T Sbjct: 407 TQC 409 >UniRef50_Q83H95 Porphobilinogen deaminase n=2 Tax=Tropheryma whipplei RepID=Q83H95_TROW8 Length = 321 Score = 268 bits (687), Expect = 1e-70, Method: Composition-based stats. Identities = 108/331 (32%), Positives = 153/331 (46%), Gaps = 42/331 (12%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR S LA Q V+ + L + V + T D G FV Sbjct: 3 PLRIGTRSSLLATAQTAQVQKTMRDVFL-LDTQQVLIQTGSVRRRD---------GSFVA 52 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L ALLE D+AVHS+KD+P+ +G + + REDP D + +L LP+G+ Sbjct: 53 ALRTALLEGECDLAVHSLKDIPIAPHEGTLITAVLPREDPCDVLCARKDLTLTTLPSGAK 112 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGT+S RR+ Q+ RPDL + SLRGN+ RL LD DAI+L+ AGLKR+ E I Sbjct: 113 VGTASARRRAQILNFRPDLDVVSLRGNIDKRLIHLDT--LDAIVLSAAGLKRIDREDAIT 170 Query: 185 AALPPEISLPAVGQGAVGIE-CRL--DDSRTRELLA-ALNHHETALRVTAERAMNTRLEG 240 + A GQG++ IE CR DD + R + L++ + TAER + + L+ Sbjct: 171 ESFDIHDWPTAAGQGSLAIEVCRAQLDDPQNRVAVTYRLDNPMARVTTTAERGVLSLLQA 230 Query: 241 GCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIR------------------------G 274 C PI +A D + L A V + DG Sbjct: 231 DCFSPIAVHAVYTANDKSLRLHAKVFSRDGKIFCESIRFARLVKQLTDTNQNHTKNSGSD 290 Query: 275 ERRGAPQDAEQMGISLAEELLNNGAREILAE 305 + A + A + ++ +ELL+ AREIL + Sbjct: 291 DIGNALEVAMTLAKTVVDELLSKNAREILKQ 321 >UniRef50_A7BMK1 Porphobilinogen deaminase n=1 Tax=Beggiatoa sp. SS RepID=A7BMK1_9GAMM Length = 211 Score = 267 bits (683), Expect = 4e-70, Method: Composition-based stats. Identities = 124/211 (58%), Positives = 149/211 (70%), Gaps = 1/211 (0%) Query: 99 CEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSK 158 RE+P DAFVSN Y +L ALP G+IVGTSSLRRQ QL RPDL IRSLRGNVGTRLSK Sbjct: 1 MRREEPFDAFVSNTYATLAALPEGAIVGTSSLRRQSQLLAHRPDLQIRSLRGNVGTRLSK 60 Query: 159 LDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAA 218 LDNG+YDAI+LA GLKRLGL RIR + I LPA+GQGA+GIECR DD TR+ + Sbjct: 61 LDNGDYDAIVLAAVGLKRLGLVERIREIIDSTIMLPAIGQGAIGIECRQDDLETRQHIDN 120 Query: 219 LNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERR 277 LN +T V AERA+N LEGGCQVPI YAE+ E + +R LVG +G I+R + Sbjct: 121 LNDPDTQDCVIAERALNESLEGGCQVPIAGYAEIQSSENLTMRGLVGDIEGQHILRHNLQ 180 Query: 278 GAPQDAEQMGISLAEELLNNGAREILAEVYN 308 GA A ++G SLA+ LL GA +IL ++ + Sbjct: 181 GARHLAAELGKSLAKVLLTQGAAQILEKLKD 211 >UniRef50_UPI000038E213 porphobilinogen deaminase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E213 Length = 285 Score = 265 bits (679), Expect = 1e-69, Method: Composition-based stats. Identities = 91/263 (34%), Positives = 139/263 (52%), Gaps = 10/263 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 + I TR S LAL QA+ VKD L + G V + + GD + PL ++ G+FV Sbjct: 2 PVTIGTRNSKLALIQANSVKDALESR--GYEVNIKSYTSAGDSNKNIPLYRMSSTGVFVD 59 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 EL +L+ D+AVHS KD+P +GL + + R+D RD +S L+ + AGS+ Sbjct: 60 ELNERVLKGEIDLAVHSAKDIPSNIQKGLEITAVTGRDDFRDVLISR--TPLEEMTAGSV 117 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSS+RR Q P++ + +RGN+ TR+SK +Y II+A+A KR+ L+ Sbjct: 118 IGTSSMRRIRQAMTVNPEITVSDIRGNIDTRISKYTEKKYTGIIIAMAAYKRMKLDIE-H 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L E LPA QG + I + + + + +N ET + ER + T L GC + Sbjct: 177 FILSEEQFLPAPNQGIIAIVGKSNSPASI-ISGEINDRETYRDMKNERFIATSLNLGCSM 235 Query: 245 PIGSYAELIDGEIWLRALVGAPD 267 P+G ++ DG+I R + D Sbjct: 236 PVGILSK--DGKIKTR--FYSLD 254 >UniRef50_Q04X38 Bifunctional porphobilinogen deaminase/uroporphyrinogen synthase n=4 Tax=Leptospira RepID=Q04X38_LEPBL Length = 542 Score = 261 bits (668), Expect = 2e-68, Method: Composition-based stats. Identities = 89/279 (31%), Positives = 127/279 (45%), Gaps = 32/279 (11%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + VL+IA+R+S LA Q + V D L P + +EL GD+ L TPL K+G +G+ Sbjct: 1 MSRVLKIASRKSALAKLQTYLVLDALKKKFPNIQIELHFREASGDLDLQTPLWKMGTRGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F ++L L+E + D+ +HS KD+ +E G +V + +R D RD + P+ Sbjct: 61 FTQDLTKDLVEKKVDLVIHSWKDLDLEGHSGTTIVGVLDRADQRDVLLWKKSSLSKNFPS 120 Query: 122 GSIVGTSSLRRQCQLAERRPD----------LIIRSLRGNVGTRLSKLDNGEYDAIILAV 171 + TSS RR+ L + + LI +RGN+ TR+ K N + D ++LA Sbjct: 121 ELKIQTSSPRREYNLKKFLNNSLPSRYKNSSLIFLPVRGNIQTRIRKWRNSDSDGLVLAK 180 Query: 172 AGLKRL----------------------GLESRIRAALPPEISLPAVGQGAVGIECRLDD 209 A L RL LE I LP +S A QGA+ E R DD Sbjct: 181 AALDRLLSEDFLNSNELEYQEIRKFLKEILEESIFQVLPLSLSPSAPAQGAIAAEVRTDD 240 Query: 210 SRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGS 248 + AL+ E V ER R GGC IG Sbjct: 241 EWALGFVRALSKPEVVSAVEEERNTLKRFGGGCHQKIGV 279 >UniRef50_A9V9E0 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V9E0_MONBE Length = 643 Score = 261 bits (667), Expect = 3e-68, Method: Composition-based stats. Identities = 99/206 (48%), Positives = 124/206 (60%), Gaps = 6/206 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LA+WQ +V ++L +HPG+ +VP+ T GD L L K G+F Sbjct: 417 IRIGTRSSVLAMWQTRWVVERLTRAHPGVRFSVVPLSTVGDANLTLDLNKFSTTGIFTDA 476 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS----LDALPA 121 L ALL DI VHS+KD+P G L I REDPRD V ++ S L LPA Sbjct: 477 LVRALLAQEVDILVHSLKDLPSTISPGTQLAAIGPREDPRDVVVFHHRHSEIKDLAQLPA 536 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN--GEYDAIILAVAGLKRLGL 179 G++VGTSS RR+ QLA P L +RGNV TRL KLD+ YDA+ LA AGL RLGL Sbjct: 537 GAVVGTSSTRRRAQLAAAYPQLRFAPVRGNVMTRLRKLDDPANGYDALCLAAAGLIRLGL 596 Query: 180 ESRIRAALPPEISLPAVGQGAVGIEC 205 E+RI LP +S A+GQGA+GI+ Sbjct: 597 EARIGQFLPLTVSRHAIGQGALGIQV 622 >UniRef50_UPI0001C31A39 porphobilinogen deaminase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31A39 Length = 314 Score = 259 bits (662), Expect = 1e-67, Method: Composition-based stats. Identities = 131/292 (44%), Positives = 168/292 (57%), Gaps = 13/292 (4%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +VLRI TR S LAL QA +V L G VE++P+ T GD +G K +V Sbjct: 2 SVLRIGTRASALALVQAEHVASLLRDG--GAQVEVIPITTSGDRGR-----LLGDKSRWV 54 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE ALL + D+AVHS KDVP E P G L + R D RDA SL+ LP G+ Sbjct: 55 KELEAALLADEVDVAVHSAKDVPAELPDGFVLAGVPARADARDALCG--AASLEQLPDGA 112 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +VGTSSLRR +L RPDL + +LRGNV TRL KL +G+ AI+LAVAGL+RL + I Sbjct: 113 VVGTSSLRRAAELRALRPDLGVVALRGNVDTRLRKLADGQAAAIVLAVAGLERLDRGAAI 172 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 A + +PA GQGA+ +E R DD R R AA+ + A + AERA+ RL C Sbjct: 173 GAV--LDQLVPAPGQGALALETRADDDRARAAAAAITDADAAACLAAERALVRRLGATCH 230 Query: 244 VPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAPQ-DAEQMGISLAEE 293 P+G++A DG + LR+ VG PDGS +R E A D E G++ Sbjct: 231 TPLGAHAVRTADGGLRLRSFVGLPDGSAWLRDELSAAAGIDPETFGVAAGTR 282 >UniRef50_A5K0J5 Porphobilinogen deaminase, putative n=1 Tax=Plasmodium vivax RepID=A5K0J5_PLAVI Length = 341 Score = 259 bits (662), Expect = 1e-67, Method: Composition-based stats. Identities = 90/322 (27%), Positives = 144/322 (44%), Gaps = 69/322 (21%) Query: 45 GDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDP 104 GD ILD + GGKG+F KEL+ L++ I VHS+KDVP+E P+ + L +R+ Sbjct: 2 GDHILDKKVGLFGGKGIFTKELDEQLIKKNVHICVHSLKDVPMELPEHVQLSCFLKRDTI 61 Query: 105 RDAFVSNNYDSLDALPAGS---------------------------------------IV 125 DAF+S Y +L+ + + Sbjct: 62 NDAFLSVKYATLEDMNKRKMANKVEEESDQEKGTIQQMTNQGLKRDNCEGDKCTNFIPTI 121 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR Q+ ++ ++++RGN+ TR++KL NG+YDAII+A GL+RL + +R Sbjct: 122 GTSSLRRSSQIKYTYKNVAVKNVRGNINTRIAKLCNGQYDAIIIAKCGLERLLTKKVVRN 181 Query: 186 AL------PPEISL------------------------PAVGQGAVGIECRLDDSRTREL 215 + PPE L PA+ QG + + +D T + Sbjct: 182 IIRGKGKVPPEKFLLNHNDMETNLRLLRIQQINRRTIYPALCQGIIAVTSHKNDVDTSNI 241 Query: 216 LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE 275 L +N + + ER+ ++EG C +PIG YA+++ GEI A++ G + Sbjct: 242 LKNINDEKAQIMANVERSFLYQIEGNCMMPIGGYAQIVGGEIVFNAVINDTHGREKYHVR 301 Query: 276 RRGAPQDAEQMGISLAEELLNN 297 G Q+ + A ++ Sbjct: 302 EVGTVQNCNNIAAMAATKMKEK 323 >UniRef50_B0SF66 Bifunctional porphobilinogen deaminase/uroporphyrinogen synthase n=2 Tax=Leptospira biflexa serovar Patoc RepID=B0SF66_LEPBA Length = 511 Score = 250 bits (640), Expect = 4e-65, Method: Composition-based stats. Identities = 88/314 (28%), Positives = 137/314 (43%), Gaps = 37/314 (11%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + ++I R S L+ Q H V + L + L E + + GD L TPL + GG+G+ Sbjct: 1 MSETIKIGGRSSLLSRIQIHTVTNALKEKNKDLNFETIFRESSGDKDLTTPLWQFGGQGI 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F K+L+ LL ++ DI +HS KD+ ++ + L+ + RED RD + ++ LP Sbjct: 61 FTKDLQEDLLNHKVDIVIHSYKDMDLKERKETTLIPVLPREDVRDVLLFKKNKWIN-LPN 119 Query: 122 GSIVGTSSLRRQC----QLAERRP------DLIIRSLRGNVGTRLSKLDNGEYDAIILAV 171 + TSS RR+ L P ++ I S+RGN+ TRL K + E I++A Sbjct: 120 EITILTSSPRREYHIKEFLRNYFPTPINNFEIKIESVRGNIQTRLRKYLDHESGGILVAK 179 Query: 172 AGLKRL----------------------GLESRIRAALPPEISLPAVGQGAVGIECRLDD 209 A L R+ + + LP I A QGA+ E R +D Sbjct: 180 AALDRILNFQDPDQLLPELKEIQQLIKDTMNVSLFMVLPSSIFPSAPAQGALCAEIRKED 239 Query: 210 SRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYA--ELIDGEIWLRALVGAPD 267 LL+ ++ ET L ER + +R GGC IG ++R + D Sbjct: 240 KHLETLLSKISDSETNLTTNEEREILSRYGGGCHQKIGVTVLHREYGKVCFIRGI--TED 297 Query: 268 GSQIIRGERRGAPQ 281 G + E +P Sbjct: 298 GQILQTKELSESPN 311 >UniRef50_C0EAN0 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum DSM 5476 RepID=C0EAN0_9CLOT Length = 292 Score = 250 bits (638), Expect = 6e-65, Method: Composition-based stats. Identities = 90/294 (30%), Positives = 131/294 (44%), Gaps = 18/294 (6%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 + I Q+ L+ A ++ L + HP L ELVP+ G T L Sbjct: 13 EKIHIGCAQNELSRNFADHLAQCLHSYHPELTAELVPIKNTGADEEPT---------LVA 63 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 + LE AL++ R D+AV+ D+P+E L +V I RED RDA V P S Sbjct: 64 RRLEQALIDCRVDLAVYHALDLPLELHPELPIVAISSREDVRDALVFPQG---KQQPDFS 120 Query: 124 I-VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 +G +S R+Q QL PD I + G V +L++LD GEY A++L A L GL+ R Sbjct: 121 KPIGCTSRRQQVQLHRVFPDCITAPVGGTVAEQLARLDQGEYGALVLPAAQLGWFGLQQR 180 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 + E +PA G A+ ++ R LL + ++ V ER LE Sbjct: 181 VGQLFCVEELVPAAGHAAIAVQARE--EFDAGLLECFHSWDSWDAVFCEREFARALEEE- 237 Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIR-GERRGAPQDAEQMGISLAEELL 295 PI +AE+ + + A + I R G +DA ++G LA EL Sbjct: 238 PGPIAVHAEVKGETLSVVG-FYADEAEGIYRMSSMSGDRKDAGRLGFELAAELK 290 >UniRef50_B1ZV87 Porphobilinogen deaminase n=2 Tax=Opitutaceae RepID=B1ZV87_OPITP Length = 284 Score = 247 bits (631), Expect = 4e-64, Method: Composition-based stats. Identities = 94/260 (36%), Positives = 126/260 (48%), Gaps = 15/260 (5%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L +ATR+SPLAL Q V L A G+ EL+ +VT GD + L + GGKGLF Sbjct: 2 KKLILATRKSPLALRQTEMVAAHLEAR-LGVQTELLKLVTTGDRQTEWSLEQKGGKGLFT 60 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 ELE AL AD+AVHS KD+P + L + R D RD V + A Sbjct: 61 SELENALRRGEADLAVHSTKDLPGDMAAELAVAGYLPRADARDVLVLRAGVA-----APK 115 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESR 182 + T S RR+ Q+A+ P + +RGNV TRL K+ G D +LA AGL RLG+ + Sbjct: 116 SLATGSPRRRLQIAKLYPGVTFTEIRGNVDTRLKKIGELGVADGTVLASAGLNRLGIGNW 175 Query: 183 IRAALP---PEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 +PAVGQGA+ ++CR D+ A + T V ERA L Sbjct: 176 PGVEFHALGFNDMVPAVGQGAIAVQCRAADAA---RFAPVFDAATKRAVDVERAFQAALG 232 Query: 240 GGCQVPIGSYAELIDGEIWL 259 GCQ G++ + + Sbjct: 233 VGCQTAFGAH--VAGDTLHF 250 >UniRef50_Q86ET2 Clone ZZD1450 mRNA sequence n=3 Tax=Schistosoma japonicum RepID=Q86ET2_SCHJA Length = 277 Score = 236 bits (604), Expect = 6e-61, Method: Composition-based stats. Identities = 83/207 (40%), Positives = 109/207 (52%), Gaps = 17/207 (8%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + +R+ +R+S LAL Q L P ++ E+V + T GD ILD PL+K+G K L Sbjct: 6 SQHAVRVGSRRSNLALLQTEMAISLLKVQKPHIMFEVVEIATVGDEILDVPLSKIGDKSL 65 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDSLDA 118 F KELE +LL D+ VHS+KDVP P GL L + R P D + N L Sbjct: 66 FTKELEKSLLVGEVDLVVHSLKDVPSVLPTGLVLGCVFGRSSPEDVVLMAPHNRGMKLSD 125 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG--------------EY 164 LP G+ VGTSS+RR L + P L S+RGN+ TRL+KLD Y Sbjct: 126 LPVGATVGTSSIRRVATLIRKYPHLKFISIRGNLNTRLAKLDTPSNLQKQCCTGNQSLSY 185 Query: 165 DAIILAVAGLKRLGLESRIRAALPPEI 191 DA+ILA AG++R+G RI L Sbjct: 186 DALILAKAGVERMGWVDRIDQVLSDSF 212 >UniRef50_Q4E9D5 Porphobilinogen deaminase (Fragment) n=1 Tax=Wolbachia endosymbiont of Drosophila ananassae RepID=Q4E9D5_9RICK Length = 199 Score = 235 bits (601), Expect = 1e-60, Method: Composition-based stats. Identities = 81/202 (40%), Positives = 121/202 (59%), Gaps = 6/202 (2%) Query: 97 TICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRL 156 + ER P DAF+S+ ++SL++LP + + TS++RR+ QL RPDL I LRGNV TRL Sbjct: 1 CVLERLSPCDAFISHKHNSLESLPQQATIATSAIRRKVQLLNFRPDLNIVPLRGNVTTRL 60 Query: 157 SKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELL 216 N +D IILA AGL RL I LPP++ L AVGQGA+ I+CR +D + +LL Sbjct: 61 ---QNQSFDGIILAEAGLIRLEKHHLITEVLPPKVMLSAVGQGAICIQCRRNDVKIIDLL 117 Query: 217 AALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGE 275 +N++ + + V +ER+ + G C P+ + AE + + ++LR ++ DG I E Sbjct: 118 EKINNNMSFIGVKSERSFMKTVNGSCFTPLAALAEYVSENMLYLRCMLA--DGKNIYFTE 175 Query: 276 RRGAPQDAEQMGISLAEELLNN 297 R +DAE+MG+ EL + Sbjct: 176 RTSFIEDAEKMGMDAGLELKSK 197 >UniRef50_Q6MHU0 Hydroxymethylbilane synthase n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MHU0_BDEBA Length = 502 Score = 232 bits (593), Expect = 1e-59, Method: Composition-based stats. Identities = 82/287 (28%), Positives = 124/287 (43%), Gaps = 31/287 (10%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LRI+ R+S LA QA+ V D L +P + ++ + GD L PL K+ KG+F ++ Sbjct: 3 LRISARKSDLARLQAYMVGDALKEKNPQIEIDYRFRESLGDKNLTDPLWKIPEKGVFTED 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN--YDSLDALPAGS 123 LL + D+ VHS KD+P E + R D RD + +D + Sbjct: 63 FFGELLRDETDLVVHSWKDLPTEHKSETVIAATLPRADQRDLLLVKKSHFDKIKTSKT-L 121 Query: 124 IVGTSSLRRQCQL----AERRP----DLIIRSLRGNVGTRLSKL-DNGEYDAIILAVAGL 174 V +SS RR+ L E P D+ S+RGN+ TR+ KL ++ E D +I+A A Sbjct: 122 KVFSSSPRREYNLTGFFKEHLPFGLQDVKFESVRGNMLTRVRKLIESPETDGLIVAKAAF 181 Query: 175 KRLG-----------------LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLA 217 RL LP ++ A QGA+ +E ++LL Sbjct: 182 DRLFSATLPEFLEGQQQLRQYFNELNWVVLPLSVNPNAAAQGALAVEVLKSRQDLQDLLQ 241 Query: 218 ALNHHETALRVTAERAMNTRLEGGCQVPIG--SYAELIDGEIWLRAL 262 +++H +T ER + + GGC IG A L+ L Sbjct: 242 SIHHADTFHCSQKERDVLSSFGGGCHQKIGVAVLARPYGQITLLKGL 288 >UniRef50_B6YQR9 Hydroxymethylbilane synthase/uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YQR9_AZOPC Length = 682 Score = 225 bits (574), Expect = 2e-57, Method: Composition-based stats. Identities = 80/222 (36%), Positives = 119/222 (53%), Gaps = 18/222 (8%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG----- 60 LR+ +R SPL+L Q V + P + +L+ + + GD L + Sbjct: 11 LRVISRNSPLSLLQVKEV----FSFFPNIDYQLITIESFGDKNKHVALFDISNVSSFFLE 66 Query: 61 ------LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD 114 F +EL+ AL+ N+ADIAVHS KD+P P L L + + D D+ +S N Sbjct: 67 EESISDFFTRELDEALIYNKADIAVHSAKDLPYPLPYDLELFALFQAMDKSDSLISRNNL 126 Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174 +L+ LP + VGTSS +R+ +L + RPDL + S+RGN+ R++K+DNG DA+I+A L Sbjct: 127 TLEQLPPRARVGTSSQKRKTELLKIRPDLEVVSIRGNIEERIAKMDNGFIDALIVATCAL 186 Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELL 216 RLG+E+RI LP E QG + I R +D + L Sbjct: 187 IRLGMEARIACILPFETH---SLQGNLAIVGRKNDKNVKNLF 225 >UniRef50_B4UXX3 Porphobilinogen deaminase 2 (Fragment) n=1 Tax=Streptomyces sp. Mg1 RepID=B4UXX3_9ACTO Length = 231 Score = 225 bits (574), Expect = 2e-57, Method: Composition-based stats. Identities = 87/223 (39%), Positives = 117/223 (52%), Gaps = 8/223 (3%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +R+ TR SP+AL Q D A +P +V+++V +V+ GD PL+ +GGKG F Sbjct: 9 TTVRLGTRPSPMALEQTGRFADVFRARYPQVVLDIVEIVSEGDR-HRGPLSTIGGKGAFT 67 Query: 64 KELEVALLENRADIAVHSMKDVPVEFP--QGLGLVTICEREDPRDAFVSNNY---DSLDA 118 + + LL+ R + KDVP G+ + + RED RDA V +L Sbjct: 68 RNADRYLLDGRVQATIACAKDVPGPHDRSPGIVIAAVLPREDTRDALVLPTGHPVTTLAE 127 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDA--IILAVAGLKR 176 LP G+ VGTS+ RR L P L+ +RGN +RL LD G A +I A+AGL+R Sbjct: 128 LPPGTRVGTSAPRRSALLKALHPTLVQVPIRGNADSRLRALDAGRLGADVMIAALAGLRR 187 Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAAL 219 LG E R L P + LPA G G V +E R DD T LLA L Sbjct: 188 LGHEDRASEILDPAVWLPAAGAGTVIVEHRSDDPATGWLLAPL 230 >UniRef50_Q6MEK3 Putative Porphobilinogen deaminase n=2 Tax=Parachlamydiaceae RepID=Q6MEK3_PARUW Length = 233 Score = 224 bits (571), Expect = 3e-57, Method: Composition-based stats. Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 3/218 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 + + R SPL+ Q + L + +P + + T GD+ T L + F KE Sbjct: 18 ISVGARSSPLSRAQVQEILKALRSFYPSIEFTISYFDTIGDLDQKTSLRDLDKTNFFTKE 77 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 ++ A+L+ + I +HS KD+P P GL L+ + + D D V + ++L LP S + Sbjct: 78 IDEAILQKKCQIGIHSAKDLPDPIPDGLQLICLTKGVDCSDVLVLRDGETLQTLPPHSRI 137 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 TSS+RR+ + R D I LRG + RL+ L+ + D +++A A L RLGL R Sbjct: 138 ATSSIRRENIVKLLRNDFIFLDLRGTIHQRLALLEKKQADGVVVAEAALIRLGLTHLNRI 197 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHE 223 LP GQG + I R DD++ + L A L+ + Sbjct: 198 RLP---GTTVEGQGQLAIIARKDDAKMQTLFACLDVRK 232 >UniRef50_A8I2X7 Porphobilinogen deaminase n=1 Tax=Chlamydomonas reinhardtii RepID=A8I2X7_CHLRE Length = 380 Score = 216 bits (551), Expect = 8e-55, Method: Composition-based stats. Identities = 91/234 (38%), Positives = 119/234 (50%), Gaps = 13/234 (5%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMA----SHPGLVVELVPMVTRGDVILDTPLAKVGG 58 L IATR S LA Q V+ L+A L + + + +RGD L +G Sbjct: 60 QRPLVIATRPSKLAKEQTRQVQQLLLAAAQLKDEQLQLSTLELASRGDTTQGVSLRSLGS 119 Query: 59 KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118 G F +EL+ A+L AD++VHS+KD P GL L R DPRD ++ SL Sbjct: 120 -GAFTEELDQAVLSGAADMSVHSLKDCPAALAPGLLLAACLPRADPRDVLIAPEATSLGE 178 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 L GS VGTSS RR Q+ P L + LRGNV +RL ++ + + A +LA AGLKRLG Sbjct: 179 LVPGSRVGTSSSRRAAQIKHSFPHLQVVQLRGNVDSRLGRIRSRDIGATVLAAAGLKRLG 238 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232 + + GAVG+ CR DD LL A++H TAL V AER Sbjct: 239 VMNSDEGD--------TTATGAVGVVCRADDEWVVGLLDAISHRGTALEVAAER 284 >UniRef50_Q6Q923 Predicted porphobilinogen deaminase n=2 Tax=environmental samples RepID=Q6Q923_9GAMM Length = 291 Score = 209 bits (532), Expect = 1e-52, Method: Composition-based stats. Identities = 83/251 (33%), Positives = 117/251 (46%), Gaps = 15/251 (5%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 ++IA+R S LAL Q K S +++ + T GD I + K FV Sbjct: 2 TIKIASRSSKLALAQVEEFVKKFGIS----DYKIIKVKTEGD-IKSANGETLFDKAHFVS 56 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 +++ LL ADIAVHS KD P GL L + +D + D ++ Sbjct: 57 DVQKCLLNGEADIAVHSAKDTPAGETTGL-LRYFLPSQSNQDVLIFREEDKFNS---EMK 112 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSSLRRQ Q + I +L GNV TRL KL GEYD IILA AGL RL L + ++ Sbjct: 113 LGTSSLRRQLQAKHHLNAINIVNLSGNVDTRLEKLSQGEYDCIILAKAGLARLKLLNELQ 172 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSR--TRELLAALNHHETAL--RVTAERAMNTRLEG 240 + + A GQG + IE D S LL ++ + L ++ ER++ + Sbjct: 173 YEVMDWST--ASGQGFLCIEVLNDPSADIYNFLLKSIREIDLNLGKNISTERSILEAINA 230 Query: 241 GCQVPIGSYAE 251 GC I + Sbjct: 231 GCNSAISIQTQ 241 >UniRef50_Q9PK95 Probable porphobilinogen deaminase n=13 Tax=Chlamydiaceae RepID=HEM3_CHLMU Length = 242 Score = 201 bits (511), Expect = 4e-50, Method: Composition-based stats. Identities = 69/197 (35%), Positives = 105/197 (53%), Gaps = 3/197 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LR+A+R+SPLA+ QAH +L P L +++ T+GD+ TPL V G F Sbjct: 20 PLRLASRKSPLAVLQAHECLRRLQTFFPRLWGQVITETTQGDLDQHTPLHSVENTGFFTD 79 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 +++ + + D+A+HS KD+P E P+ + I DPRD V L P+ Sbjct: 80 DIDFLVQSGKCDLAIHSAKDLP-EKPKARVI-AITASIDPRDILVFQEKYLLQPFPSRLR 137 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +G SS RR+ ++ P +I +RG + TRL+ LD ++DAI++A A + RLGL Sbjct: 138 IGCSSDRRRALISSLYPSAVITDIRGTIQTRLALLDQQKFDAIVMANAAVSRLGLRLPCT 197 Query: 185 AALPPEISLPAVGQGAV 201 LPP P G+ A+ Sbjct: 198 VVLPPPYH-PFQGRLAI 213 >UniRef50_D0RNS6 Putative porphobilinogen deaminase (Pbg)(Hydroxymethylbilane synthase) (Hmbs) (Pre-uroporphyrinogen synthase) n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RNS6_9RICK Length = 492 Score = 198 bits (504), Expect = 2e-49, Method: Composition-based stats. Identities = 79/281 (28%), Positives = 120/281 (42%), Gaps = 28/281 (9%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + L I +R S LA Q VK +L + + T+GD K G G+ Sbjct: 1 MSLSLIIGSRASFLAKIQTFIVKQELKKKIKNIKITTKYHSTKGDKNQGHMPWKNLGYGI 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F L L+ + VHS KD+PV + + R+DPRD + Sbjct: 61 FTTSLTNELINKNFNCVVHSYKDLPVL--KSKTDYYVITRDDPRDVLLVKKKCLNK---K 115 Query: 122 GSIVGTSSLRRQCQLAERR-----PDLIIRSLRGNVGTRLSK-LDNGEYDAIILAVAGLK 175 IVGTSS RR+ + + + D+ +++RGNV TRL K + +YDA+ +A A + Sbjct: 116 KFIVGTSSPRRKSSVKDLKDLTGIKDIKTKTIRGNVTTRLLKVISKNQYDAVFMAKAAID 175 Query: 176 R----------------LGLESRIR-AALPPEISLPAVGQGAVGIECRLDDSRTRELLAA 218 R L L + + LP I A QGA+ +E +D +T+ L Sbjct: 176 RIFKYGNKVDKVETKKFLNLFKKFKPFILPLSIFPTAASQGAIAVEYLKNDKKTKSTLNK 235 Query: 219 LNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWL 259 +N +T ER++ + GGC + IG E I +L Sbjct: 236 INCKKTLSICNQERSLLKKYGGGCGLDIGITIEEIKNNNFL 276 >UniRef50_C5LJF7 Porphobilinogen deaminase, putative n=5 Tax=Perkinsus marinus ATCC 50983 RepID=C5LJF7_9ALVE Length = 556 Score = 196 bits (499), Expect = 9e-49, Method: Composition-based stats. Identities = 79/284 (27%), Positives = 118/284 (41%), Gaps = 40/284 (14%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 +VL I +R+S LA Q + D L G+ VE GD L PL K+ G+F Sbjct: 7 PSVLHIGSRRSDLARLQTLMIADLLQDE-MGVKVECHYREAPGDTNLKDPLWKMPETGVF 65 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 L L+ D+ VHS KD+P+ G +V R DPRD + D+++ + + Sbjct: 66 TSFLRDGLMNGAFDLVVHSWKDLPLAEESGTTVVATLPRADPRDLLLIRR-DAIEEMTSE 124 Query: 123 S---IVGTSSLRRQCQLAERRP-------DLIIRSLRGNVGTRLSKLDNGEY-------- 164 IV +SS RRQ L + R +RGN+ TR+ KL + Sbjct: 125 GGKLIVLSSSPRRQFNLTPFLESVVPGVTSVQFRDVRGNIQTRMKKLMDPTIHDESLGCR 184 Query: 165 -DAIILAVAGLKRL----------------GLESRIRAALPPEISLP-AVGQGAVGIECR 206 +++A A + R G S R + P + P A QGA+GIE Sbjct: 185 PHGLVVAKAAVDRFIRSTREEFKESRQLVQGYISECRCMVLPLSANPTAAAQGALGIEVS 244 Query: 207 L--DDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGS 248 + R+++ +LN T + E+ + GGC IG Sbjct: 245 TAPEKEHVRKIVRSLNDRSTFDAASKEKELLNSYGGGCHQKIGC 288 >UniRef50_Q9HMY5 Probable porphobilinogen deaminase n=2 Tax=Halobacterium salinarum RepID=HEM3_HALSA Length = 396 Score = 192 bits (489), Expect = 1e-47, Method: Composition-based stats. Identities = 72/159 (45%), Positives = 96/159 (60%), Gaps = 2/159 (1%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M +R+ATR S LAL QA V D L VELV + T GD + D ++ +G G Sbjct: 1 MSSQQIRLATRGSDLALRQAGEVVDTLEDRRHD--VELVEVETEGDRVTDALISDLGKTG 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 FV+ L+ ++E D AVHSMKDVP E P+ L + + RE+P D V+ + L+ LP Sbjct: 59 AFVRALDQEVMEGTVDAAVHSMKDVPTEVPEDLVVAAVPHRENPADVLVTPDGTDLEDLP 118 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL 159 AGS+VGT+SLRR Q+ RP L + +RGNVGTR+ KL Sbjct: 119 AGSVVGTASLRRGAQVQAHRPGLDVEPIRGNVGTRVEKL 157 Score = 135 bits (341), Expect = 2e-30, Method: Composition-based stats. Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 1/146 (0%) Query: 161 NGEYDAIILAVAGLKRLGLESRIR-AALPPEISLPAVGQGAVGIECRLDDSRTRELLAAL 219 + EYDA+++A GL+R GL + L +PA GQGA+ + R D L AL Sbjct: 246 DTEYDALVMARVGLERTGLLHHVGIEELSTGTHVPATGQGALCVTARRDSDVVDTLRDAL 305 Query: 220 NHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGA 279 H T + VTAER + L GGC PIG +A + I V + DGS+ + R Sbjct: 306 EHVRTRVEVTAERVVLEELGGGCIAPIGVHALVQGDTIRTAVQVFSQDGSEQVGETRELD 365 Query: 280 PQDAEQMGISLAEELLNNGAREILAE 305 + LA +L + GA +++ + Sbjct: 366 AEQYATDARELAADLRDRGAADLIED 391 >UniRef50_Q18ES3 Hydroxymethylbilane synthase (Porphobilinogen deaminase) n=9 Tax=Halobacteriaceae RepID=Q18ES3_HALWD Length = 394 Score = 181 bits (459), Expect = 4e-44, Method: Composition-based stats. Identities = 66/157 (42%), Positives = 95/157 (60%), Gaps = 4/157 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 L +ATR S LAL QA V++ L V+L+ + TRGD I D + ++G G FV+ Sbjct: 10 TLTLATRGSDLALKQATSVQEALTDER--YEVDLIEVETRGDQIQDELIHQLGKTGAFVR 67 Query: 65 ELEVALLE--NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 L+ +L+ AD AVHSMKD+P + P L + I +R P D ++ + L LP+G Sbjct: 68 ALDKKVLDPTAEADAAVHSMKDMPTDSPDDLVVAGIPQRAPPGDLLITTDGQRLSDLPSG 127 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL 159 + +GTSSLRRQ QL ++R D+ + LRGN+ TR+ KL Sbjct: 128 ATIGTSSLRRQAQLLDQRTDITVEPLRGNIDTRIEKL 164 Score = 139 bits (350), Expect = 1e-31, Method: Composition-based stats. Identities = 51/150 (34%), Positives = 75/150 (50%), Gaps = 1/150 (0%) Query: 156 LSKLDNGEYDAIILAVAGLKRLGLESRIRAAL-PPEISLPAVGQGAVGIECRLDDSRTRE 214 L + EYDAI+LA AGL+R GL I +PA GQGA+ I + + + T + Sbjct: 228 LERSVETEYDAIVLAEAGLQRSGLIHHIEYVQLDTTTFVPAPGQGAIAITTQGEANATAQ 287 Query: 215 LLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRG 274 + A++H T + T ER + L GGC PIG +A L + + A V A DG++ + G Sbjct: 288 IREAIDHPRTRVETTVERTVLAELGGGCIAPIGVHATLQGEYVHVAAQVFASDGTETVDG 347 Query: 275 ERRGAPQDAEQMGISLAEELLNNGAREILA 304 R A +L + GA E++A Sbjct: 348 SRNLPVDAHADAAAQFANKLADRGADELIA 377 >UniRef50_B0KCR7 Porphobilinogen deaminase n=3 Tax=Thermoanaerobacter RepID=B0KCR7_THEP3 Length = 168 Score = 159 bits (402), Expect = 2e-37, Method: Composition-based stats. Identities = 48/164 (29%), Positives = 82/164 (50%), Gaps = 7/164 (4%) Query: 136 LAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPA 195 + D+ I +RGNV TRL K++ D I+L+ AGL RLGLES I PP++ +PA Sbjct: 4 IQALMSDIQIVPIRGNVRTRLKKMEELNLDGIVLSAAGLHRLGLESIITEYFPPDVVVPA 63 Query: 196 VGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAEL-- 252 QG + +E D+ +E + + T + ER + C+ P G+YA+ Sbjct: 64 PCQGILAVEIAESFDNIFQEFYSYIVDRRTFFEASVERELLKAFGVNCRQPFGAYAQYRK 123 Query: 253 --IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 + +I ++ + D ++++ E G ++ ++M L EE Sbjct: 124 EKDEEKINIKVVYQKED--KLLKSEVTGLIEETDKMIEKLIEEF 165 >UniRef50_UPI000155526F PREDICTED: similar to hydroxymethylbilane synthase n=1 Tax=Ornithorhynchus anatinus RepID=UPI000155526F Length = 218 Score = 158 bits (401), Expect = 2e-37, Method: Composition-based stats. Identities = 60/130 (46%), Positives = 78/130 (60%), Gaps = 9/130 (6%) Query: 75 ADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALPAGSIVGTSSLR 131 D+ VHS+KD+P P G + +C+RE P DA V + +L LP S+VGTSSLR Sbjct: 90 VDLVVHSLKDLPTVLPPGFTIGAVCKRESPYDAVVFHPKHVGKTLATLPEKSVVGTSSLR 149 Query: 132 RQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESRIRAALPPE 190 R QL + P L +S+RGN+ TRL KLD E+ AIILA AGL+RLG +SR+ Sbjct: 150 RAAQLQRKFPHLEFKSIRGNLNTRLRKLDELQEFSAIILAAAGLQRLGWQSRLGQVR--- 206 Query: 191 ISLPAV-GQG 199 PA G+G Sbjct: 207 -VAPAPRGRG 215 >UniRef50_C0DZX9 Putative uncharacterized protein n=1 Tax=Corynebacterium matruchotii ATCC 33806 RepID=C0DZX9_9CORY Length = 152 Score = 156 bits (394), Expect = 1e-36, Method: Composition-based stats. Identities = 54/150 (36%), Positives = 80/150 (53%), Gaps = 1/150 (0%) Query: 156 LSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTREL 215 ++K+ +GE DA++LA AGL R+ P LPA QGA+ +ECR DD+ T Sbjct: 1 MAKVHDGELDAVVLAYAGLSRVHRADEATEVFDPLEFLPAPAQGALAVECRADDADTIAA 60 Query: 216 LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRG 274 + + + ER + RLE GC P+ +YA + D + L A V A DGS +R Sbjct: 61 ITTIADSKAYACAHTERVVLARLEAGCTAPVAAYATVAADNIMTLHAAVIAMDGSATLRA 120 Query: 275 ERRGAPQDAEQMGISLAEELLNNGAREILA 304 G AE +G+++A LL++GA +LA Sbjct: 121 TAAGPIDTAENLGMTVARALLDDGASSLLA 150 >UniRef50_UPI0001B4213A porphobilinogen deaminase n=1 Tax=Listeria monocytogenes LO28 RepID=UPI0001B4213A Length = 128 Score = 144 bits (365), Expect = 3e-33, Method: Composition-based stats. Identities = 52/124 (41%), Positives = 79/124 (63%), Gaps = 2/124 (1%) Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 +PPE+ LPAVGQGA+ IECR D + R++L +++H ET + V AER +L GGC++ Sbjct: 6 EDIPPEVCLPAVGQGALAIECRESDQQIRDMLTSIHHEETGICVEAERVFLKKLNGGCEI 65 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 PI +A + + + LVG DGS I+ E+ GA + ++G +AE+LL+ GA I+ Sbjct: 66 PIAGFATRANEFVQFKGLVGNADGSIILESEQVGA--NPSEIGNKVAEDLLSEGADTIIK 123 Query: 305 EVYN 308 E+ N Sbjct: 124 ELRN 127 >UniRef50_A8CBG6 Porphobilinogen deaminase n=3 Tax=Toxoplasma gondii RepID=A8CBG6_TOXGO Length = 747 Score = 142 bits (358), Expect = 2e-32, Method: Composition-based stats. Identities = 55/163 (33%), Positives = 73/163 (44%), Gaps = 33/163 (20%) Query: 124 IVGTSSLRRQCQLAERRP--DLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL-- 179 +GT SLRRQ L P + LRGNV TR+S+++ G DA +LA AGLKRL L Sbjct: 444 RIGTCSLRRQALLYALLPPSSFQLMGLRGNVQTRMSRIEKGTLDATLLAAAGLKRLNLLS 503 Query: 180 ---------------------ESRIRAAL--------PPEISLPAVGQGAVGIECRLDDS 210 SR P ++ +PAV QG +G++CR D+ Sbjct: 504 AMLAPSPSATPSPCPAPSPNETSRGTEPGGCVEAVLLPADVFVPAVCQGIIGVQCRSADT 563 Query: 211 RTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELI 253 LL LN + + ERA L+G C+ PI AE Sbjct: 564 GILSLLRELNSPSSRGQALCERAFLRALDGSCRTPIAGIAEWR 606 Score = 117 bits (294), Expect = 5e-25, Method: Composition-based stats. Identities = 41/81 (50%), Positives = 53/81 (65%) Query: 35 VVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLG 94 + +VPM T GD L PLA+VGGKGLF KEL++ALL + D+ VHS+KDVP E P+G Sbjct: 268 ELRIVPMQTTGDKELHLPLAQVGGKGLFTKELDLALLHGQVDVVVHSLKDVPTELPEGTE 327 Query: 95 LVTICEREDPRDAFVSNNYDS 115 + REDPRDA + + Sbjct: 328 IGAYLPREDPRDALIFSRKPR 348 Score = 49.7 bits (118), Expect = 1e-04, Method: Composition-based stats. Identities = 18/67 (26%), Positives = 32/67 (47%), Gaps = 5/67 (7%) Query: 247 GSYAELIDGEI-WLRALVGAPDGSQIIRGERRG----APQDAEQMGISLAEELLNNGARE 301 G A ++ ++ PDG Q+ R ER P++AE +G ++AEE+ + Sbjct: 669 GVLATPDGKQLLRFCGVLATPDGKQLFREERTVRGVRTPEEAEALGRAVAEEIKKAAGAD 728 Query: 302 ILAEVYN 308 LA++ Sbjct: 729 RLAQIKK 735 Score = 41.6 bits (97), Expect = 0.036, Method: Composition-based stats. Identities = 12/31 (38%), Positives = 15/31 (48%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPG 33 LR+ +R SPLAL QA +L P Sbjct: 160 KTPLRVGSRASPLALAQARQFVYRLALRFPD 190 >UniRef50_UPI0001742E92 Porphobilinogen deaminase n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI0001742E92 Length = 119 Score = 129 bits (325), Expect = 1e-28, Method: Composition-based stats. Identities = 32/115 (27%), Positives = 60/115 (52%), Gaps = 2/115 (1%) Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 + + +PA GQG + I+CR +D++ R LL +N E + AER + +GGC Sbjct: 1 MSEYFDTDFFMPAPGQGILCIQCRENDNKIRHLLEIINDDEVTMMCEAEREFSKIFDGGC 60 Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 PIG + + + L+ + +GS++++ E G ++ +++ LAEE+ Sbjct: 61 HTPIGCSSVIEGDTLKLKGM-FNDNGSRMLK-EVEGNKENPKEIAQKLAEEIKKE 113 >UniRef50_Q1HRH6 Hydroxymethylbilane synthase-like protein n=1 Tax=Aedes aegypti RepID=Q1HRH6_AEDAE Length = 349 Score = 118 bits (296), Expect = 3e-25, Method: Composition-based stats. Identities = 34/111 (30%), Positives = 52/111 (46%), Gaps = 6/111 (5%) Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236 +G E RI + P L AVGQGA+ +ECR +D +L+ L H ET ++ ER+ Sbjct: 1 MGWEKRIDQVIEPSEILYAVGQGALAVECRSNDEYILNMLSKLCHLETQCKILVERSFLK 60 Query: 237 RLEGGCQVPIGSYAEL------IDGEIWLRALVGAPDGSQIIRGERRGAPQ 281 L GGC P+ L + ++ V + DG IR + + + Sbjct: 61 TLGGGCSAPVAVCTSLKRKHDSKSNYLNIQGAVWSLDGKTEIRADDGCSVE 111 >UniRef50_Q401C3 Hydroxymethylbilane synthase (Fragment) n=7 Tax=Coelomata RepID=Q401C3_CAPHI Length = 109 Score = 117 bits (294), Expect = 6e-25, Method: Composition-based stats. Identities = 41/81 (50%), Positives = 54/81 (66%), Gaps = 1/81 (1%) Query: 113 YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAV 171 +L+ LP S+VGTSSLRR QL + P L R++RGN+ TRL KLD E+ AIILA Sbjct: 29 GKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRNIRGNLNTRLRKLDELQEFSAIILAA 88 Query: 172 AGLKRLGLESRIRAALPPEIS 192 AGL+R+G ++R+ L PE Sbjct: 89 AGLQRMGWQNRVGQILHPEEC 109 >UniRef50_UPI0001698669 porphobilinogen deaminase n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2' RepID=UPI0001698669 Length = 136 Score = 112 bits (280), Expect = 2e-23, Method: Composition-based stats. Identities = 64/133 (48%), Positives = 79/133 (59%), Gaps = 11/133 (8%) Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231 AGLKRLG E RI A + PE SLPA+GQGA+GIECR DD++ L+A L+H +TA V AE Sbjct: 8 AGLKRLGFEQRITAFIAPEQSLPAIGQGAIGIECRSDDAQVNALIAPLHHVDTAACVHAE 67 Query: 232 RAMNTRLEGG-----CQV-PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQ 285 RAMN RL GG C++ G A W R+ V + GE G P +AE Sbjct: 68 RAMNNRLMGGSPCADCRLRDAGVPATSGCVVWWARSTVA-----RSCVGEAEGTPDEAES 122 Query: 286 MGISLAEELLNNG 298 +G+ LAE LL G Sbjct: 123 LGVGLAERLLELG 135 >UniRef50_B8N6H4 Putative uncharacterized protein n=1 Tax=Aspergillus flavus NRRL3357 RepID=B8N6H4_ASPFN Length = 90 Score = 100 bits (250), Expect = 6e-20, Method: Composition-based stats. Identities = 30/79 (37%), Positives = 40/79 (50%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR+S LA+ QA +++ L PG E+ + T GD T L G K L+ Sbjct: 10 PLRIGTRRSNLAMVQAEGIRNCLQKIAPGRSFEIEALRTLGDRDQLTALYNFGAKSLWTT 69 Query: 65 ELEVALLENRADIAVHSMK 83 ELE L D+ VH +K Sbjct: 70 ELEEKLNAGELDVIVHCLK 88 >UniRef50_UPI0000D9FBB5 PREDICTED: similar to lethal (3) 02640 CG9165-PA n=1 Tax=Macaca mulatta RepID=UPI0000D9FBB5 Length = 105 Score = 95.2 bits (236), Expect = 3e-18, Method: Composition-based stats. Identities = 34/111 (30%), Positives = 45/111 (40%), Gaps = 17/111 (15%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + LRI +R+S LA Q V D+L G V LV M G+ Sbjct: 5 SNATLRIGSRRSDLARLQTLMVADRLEE--MGYKVVLVGM---------------PETGV 47 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN 112 F L LL+ D+ VHS KD+P+ G + R DPRD + Sbjct: 48 FTTFLRQKLLDGSVDLVVHSWKDLPLAEEAGTTVAATLPRADPRDLIIIRK 98 >UniRef50_UPI0001C35DE1 porphobilinogen deaminase n=1 Tax=Clostridium hathewayi DSM 13479 RepID=UPI0001C35DE1 Length = 121 Score = 79.7 bits (196), Expect = 1e-13, Method: Composition-based stats. Identities = 25/112 (22%), Positives = 47/112 (41%), Gaps = 3/112 (2%) Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 E +PA GQG + +E R++D R E+ + + + ER + L+ GC Sbjct: 13 FHYFACEAFIPAGGQGILAVEGRIED-RICEMAVRIQDEDAKTCLMLERKILKLLDAGCH 71 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295 P+G Y+ + EI + + + + R G + + + A+ L Sbjct: 72 EPVGVYSRIRGEEIEVFGI--SRRDRETKRVYLTGGIGELDLLAERAAKGLR 121 >UniRef50_C5U771 Porphobilinogen deaminase n=1 Tax=Methanocaldococcus infernus ME RepID=C5U771_9EURY Length = 89 Score = 72.0 bits (176), Expect = 3e-11, Method: Composition-based stats. Identities = 26/85 (30%), Positives = 39/85 (45%), Gaps = 7/85 (8%) Query: 217 AALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER 276 +N +T L TAER L GC VP G++A+ + L+ V D ++I+ E Sbjct: 2 EKINDKKTFLETTAERKALNELGCGCHVPFGAFAKYEGKRLMLKVAVANKD--RVIKKES 59 Query: 277 RGA-----PQDAEQMGISLAEELLN 296 + AE++G SL EL Sbjct: 60 SICCEVDEIEKAEKLGESLGRELRR 84 >UniRef50_C5G109 Porphobilinogen deaminase n=1 Tax=Microsporum canis CBS 113480 RepID=C5G109_NANOT Length = 282 Score = 71.7 bits (175), Expect = 3e-11, Method: Composition-based stats. Identities = 52/233 (22%), Positives = 80/233 (34%), Gaps = 48/233 (20%) Query: 84 DVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDL 143 DV + P I + Y SL LP G+I+ TS +R QL P L Sbjct: 93 DVSTKLPDSCDPAAIPVKA-------GLPYTSLQTLPEGAIIATSLVRPSAQLRRLFPTL 145 Query: 144 IIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGI 203 ++R G +++ + A LG P QG Sbjct: 146 RFANVR------------GNVESLTIPQA----LGTVGSSTRGRPRARRR--RHQGY--- 184 Query: 204 ECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALV 263 + + + L AL + L L GC PIG E + +RA+V Sbjct: 185 ----SSAGSADRLLAL---PSVLMC--------ALRSGCNAPIGIETEWTATHLSIRAIV 229 Query: 264 GAPDGSQIIRGERRG---APQDAEQMGISLAEELLNNGAREILAEVYNGDAPA 313 + D SQ + +++ G +LA L G IL ++ N + P+ Sbjct: 230 VSLDISQSVEDAIDAMMHTKDESDAPGQALA-RLFGAGVAPILIDI-NRNQPS 280 >UniRef50_C4Z1K5 Putative uncharacterized protein n=1 Tax=Eubacterium eligens ATCC 27750 RepID=C4Z1K5_EUBE2 Length = 287 Score = 63.6 bits (154), Expect = 8e-09, Method: Composition-based stats. Identities = 47/228 (20%), Positives = 91/228 (39%), Gaps = 34/228 (14%) Query: 55 KVGGKGLFVKELEVALLENRADIAVHSMKDVPV---------EFPQGLGLVTICEREDPR 105 ++GG ++ LE AL+++ D+ + D+ + + G+ + + +R DPR Sbjct: 42 EIGGSDIY-PALE-ALIDDNIDMV---LVDMRMLVEMEKSGQQLDDGIVISGVIKRRDPR 96 Query: 106 DAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYD 165 + + ++V T S + E ++ + N+ +SKLD+ E D Sbjct: 97 YVMIRRRGT--KDVVENAVVVTDSDENAAVICEMYDNVECV-VENNIKDCMSKLDSEECD 153 Query: 166 AIILAV---AGLKRL--GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALN 220 A + A + RL GL+ + + +P GQG I S + + ++ Sbjct: 154 A-VFAFYDDIRIARLYNGLKYKYT-LMDFSDCVPPHGQGIYCILTNGKRSVIKHMFD-VS 210 Query: 221 HHETALRVTAERAMNTRLEG-----GCQVPIGSYAELIDGEIWLRALV 263 H TA+ E + RL C +Y ++ +I + A V Sbjct: 211 HRTTAMSFDIEEDIIRRLLMNDYVKSCN----AYVKISGDKIEVYADV 254 >UniRef50_Q4EB45 Porphobilinogen deaminase n=1 Tax=Wolbachia endosymbiont of Drosophila ananassae RepID=Q4EB45_9RICK Length = 62 Score = 62.0 bits (150), Expect = 2e-08, Method: Composition-based stats. Identities = 20/50 (40%), Positives = 30/50 (60%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAK 55 ++I TR S LA+ QA K KL+ S P L +E+V + + GD + LA+ Sbjct: 13 VKIGTRGSKLAVVQALEAKQKLLDSFPNLSIEIVKIKSSGDKYANANLAE 62 >UniRef50_B5XH53 Porphobilinogen deaminase n=1 Tax=Salmo salar RepID=B5XH53_SALSA Length = 55 Score = 58.6 bits (141), Expect = 3e-07, Method: Composition-based stats. Identities = 15/39 (38%), Positives = 22/39 (56%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPM 41 V+RI TR S LA Q V +KL +P + +E+V + Sbjct: 16 SRVIRIGTRNSQLARIQTDSVAEKLKGLYPDVHIEIVGI 54 >UniRef50_C2BR76 Putative uncharacterized protein (Fragment) n=1 Tax=Corynebacterium pseudogenitalium ATCC 33035 RepID=C2BR76_9CORY Length = 62 Score = 58.2 bits (140), Expect = 4e-07, Method: Composition-based stats. Identities = 16/62 (25%), Positives = 32/62 (51%) Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 P+ + + ++ +R V A DGS+ + G+ +A +G +++EL GA E+L Sbjct: 1 APVAATSRWDGDQLTVRGGVFALDGSRQLTATASGSAAEAADLGARISDELFAGGAAELL 60 Query: 304 AE 305 + Sbjct: 61 GK 62 >UniRef50_UPI0000D537E6 hypothetical protein P700755_22735 n=1 Tax=Psychroflexus torquis ATCC 700755 RepID=UPI0000D537E6 Length = 356 Score = 45.5 bits (107), Expect = 0.002, Method: Composition-based stats. Identities = 46/234 (19%), Positives = 82/234 (35%), Gaps = 38/234 (16%) Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127 +L + D+ S D + +GL + + R++P V+N+ + L G+ + Sbjct: 49 QSLRDGAGDLVAMSAFDWQQQDVEGLIIAGLLTRKEPTWVLVANDKP--EYLKQGAYILC 106 Query: 128 SS--LRRQCQLAERRPDLIIRSL-----RGNVGTRLSKLDN-------------GEYDAI 167 LRR Q+ R DL + ++ R N +S+LD G D Sbjct: 107 DHELLRR--QMMRLRGDLTLETMEEMGKRLNAAATISELDEEDIWPWVEGLLKNGNIDGF 164 Query: 168 ILAVA--GLKR-------LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAA 218 I+ A R LGL+ E +P G + R + + Sbjct: 165 IVPRAIHASHRMKSRRHTLGLQRDNSE-SNRERFIPPPLHGFTMLVGRNGFPKAS--IQD 221 Query: 219 LNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQII 272 + L E A+ LE + +G++ E L+ + DG + + Sbjct: 222 MVDQSAELAYRLEAAILESLEPSLRPIVGAFVEQRKIATILKK--ASEDGDEAL 273 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_B7LU53 Porphobilinogen deaminase n=87 Tax=cellular orga... 447 e-124 UniRef50_B5FN93 Porphobilinogen deaminase n=168 Tax=cellular org... 440 e-122 UniRef50_Q3ACT3 Porphobilinogen deaminase n=2 Tax=Bacteria RepID... 436 e-121 UniRef50_C0QU69 Porphobilinogen deaminase n=4 Tax=Bacteria RepID... 435 e-120 UniRef50_B5YJZ4 Porphobilinogen deaminase n=2 Tax=Bacteria RepID... 429 e-119 UniRef50_C0Q9U2 HemC n=2 Tax=Bacteria RepID=C0Q9U2_DESAH 428 e-118 UniRef50_Q8YVU6 Porphobilinogen deaminase n=50 Tax=cellular orga... 423 e-117 UniRef50_D1BNZ5 Porphobilinogen deaminase n=3 Tax=Veillonella Re... 422 e-117 UniRef50_Q8DIE4 Porphobilinogen deaminase n=11 Tax=cellular orga... 419 e-116 UniRef50_Q0I178 Porphobilinogen deaminase n=45 Tax=Bacteria RepI... 415 e-115 UniRef50_Q65GK1 Porphobilinogen deaminase n=98 Tax=Bacillales Re... 414 e-114 UniRef50_A1AUE7 Porphobilinogen deaminase n=44 Tax=Bacteria RepI... 413 e-114 UniRef50_B5EBG8 Porphobilinogen deaminase n=166 Tax=Bacteria Rep... 411 e-113 UniRef50_A6TJD5 Porphobilinogen deaminase n=2 Tax=Firmicutes Rep... 410 e-113 UniRef50_C9KL85 Hydroxymethylbilane synthase n=1 Tax=Mitsuokella... 409 e-113 UniRef50_Q31PM2 Porphobilinogen deaminase n=8 Tax=cellular organ... 406 e-112 UniRef50_C6HUG2 Porphobilinogen deaminase n=1 Tax=Leptospirillum... 402 e-110 UniRef50_Q5ZRY6 Porphobilinogen deaminase n=6 Tax=Legionella Rep... 399 e-110 UniRef50_Q2RJ26 Porphobilinogen deaminase n=5 Tax=Clostridia Rep... 397 e-109 UniRef50_P08397 Porphobilinogen deaminase n=59 Tax=Chordata RepI... 394 e-108 UniRef50_B2A1G7 Porphobilinogen deaminase n=1 Tax=Natranaerobius... 393 e-108 UniRef50_Q30Y29 Porphobilinogen deaminase n=13 Tax=Bacteria RepI... 393 e-108 UniRef50_Q4L709 Porphobilinogen deaminase n=88 Tax=Bacillales Re... 391 e-107 UniRef50_B3QWI1 Porphobilinogen deaminase n=12 Tax=Chlorobiaceae... 390 e-107 UniRef50_C9R7U0 Porphobilinogen deaminase n=1 Tax=Ammonifex dege... 390 e-107 UniRef50_B3E2H7 Porphobilinogen deaminase n=3 Tax=Proteobacteria... 389 e-107 UniRef50_Q54P93 Porphobilinogen deaminase n=1 Tax=Dictyostelium ... 388 e-106 UniRef50_Q2LQU2 Porphobilinogen deaminase n=1 Tax=Syntrophus aci... 385 e-105 UniRef50_A8PKX6 Porphobilinogen deaminase n=2 Tax=Gammaproteobac... 384 e-105 UniRef50_A7NKU8 Porphobilinogen deaminase n=5 Tax=Bacteria RepID... 382 e-105 UniRef50_A3ETN3 Porphobilinogen deaminase n=2 Tax=Leptospirillum... 382 e-105 UniRef50_Q1J288 Porphobilinogen deaminase n=5 Tax=Deinococci Rep... 382 e-104 UniRef50_Q180R9 Porphobilinogen deaminase n=11 Tax=Bacteria RepI... 380 e-104 UniRef50_A6WXJ2 Porphobilinogen deaminase n=56 Tax=cellular orga... 380 e-104 UniRef50_B6FXV9 Putative uncharacterized protein n=1 Tax=Clostri... 379 e-104 UniRef50_B2S842 Porphobilinogen deaminase n=38 Tax=Rhizobiales R... 377 e-103 UniRef50_A7GYU4 Porphobilinogen deaminase n=34 Tax=Campylobacter... 377 e-103 UniRef50_O94048 Porphobilinogen deaminase n=53 Tax=Saccharomycet... 375 e-103 UniRef50_A6Q7Y4 Porphobilinogen deaminase n=7 Tax=Epsilonproteob... 375 e-102 UniRef50_D0LUE1 Porphobilinogen deaminase n=1 Tax=Haliangium och... 373 e-102 UniRef50_Q43316 Porphobilinogen deaminase, chloroplastic n=61 Ta... 372 e-102 UniRef50_D2R3S6 Porphobilinogen deaminase n=2 Tax=Planctomycetac... 372 e-102 UniRef50_P28789 Porphobilinogen deaminase n=18 Tax=Saccharomycet... 371 e-101 UniRef50_A5VM67 Porphobilinogen deaminase n=9 Tax=Lactobacillus ... 370 e-101 UniRef50_Q8RFP5 Porphobilinogen deaminase n=16 Tax=Fusobacteriac... 370 e-101 UniRef50_UPI0001926E0E PREDICTED: similar to hydroxymethylbilane... 369 e-101 UniRef50_C8WXM9 Porphobilinogen deaminase n=2 Tax=Alicyclobacill... 369 e-101 UniRef50_B3T8H9 Putative Porphobilinogen deaminase, dipyromethan... 369 e-100 UniRef50_A9A1A1 Probable porphobilinogen deaminase n=3 Tax=Thaum... 369 e-100 UniRef50_A8LIJ6 Porphobilinogen deaminase n=11 Tax=Alphaproteoba... 368 e-100 UniRef50_UPI00017922DC PREDICTED: similar to porphobilinogen dea... 368 e-100 UniRef50_C1CYD9 Porphobilinogen deaminase n=3 Tax=Deinococci Rep... 367 e-100 UniRef50_D1CBT4 Porphobilinogen deaminase n=1 Tax=Thermobaculum ... 367 e-100 UniRef50_C3WGN0 Porphobilinogen deaminase n=5 Tax=Fusobacterium ... 366 e-100 UniRef50_Q3YSA8 Porphobilinogen deaminase n=17 Tax=Rickettsiales... 365 e-100 UniRef50_B0K2L4 Porphobilinogen deaminase n=7 Tax=Bacteria RepID... 364 2e-99 UniRef50_UPI0000583C22 PREDICTED: hypothetical protein n=1 Tax=S... 363 4e-99 UniRef50_C3XEZ5 Porphobilinogen deaminase n=3 Tax=Campylobactera... 362 1e-98 UniRef50_Q5HBG1 Porphobilinogen deaminase n=2 Tax=Ehrlichia rumi... 360 3e-98 UniRef50_C6XGK7 Porphobilinogen deaminase n=1 Tax=Candidatus Lib... 359 6e-98 UniRef50_Q2S2A6 Porphobilinogen deaminase n=1 Tax=Salinibacter r... 359 1e-97 UniRef50_D0NJW2 Porphobilinogen deaminase n=2 Tax=Phytophthora i... 358 2e-97 UniRef50_Q4HT06 Porphobilinogen deaminase n=1 Tax=Campylobacter ... 357 3e-97 UniRef50_C7N5L0 Porphobilinogen deaminase n=2 Tax=Slackia RepID=... 357 3e-97 UniRef50_Q11XT5 Porphobilinogen deaminase n=8 Tax=Bacteria RepID... 354 2e-96 UniRef50_A6GB01 Porphobilinogen deaminase n=2 Tax=Bacteria RepID... 354 2e-96 UniRef50_A6DBT5 Porphobilinogen deaminase n=1 Tax=Caminibacter m... 354 2e-96 UniRef50_A8U3E9 Porphobilinogen deaminase n=1 Tax=alpha proteoba... 353 6e-96 UniRef50_B3U3W9 Hydroxymethylbilane synthetase n=1 Tax=Oxyrrhis ... 352 9e-96 UniRef50_A6GVP0 Hydroxymethylbilane synthase n=18 Tax=Bacteroide... 352 1e-95 UniRef50_C4Z552 Porphobilinogen deaminase n=8 Tax=Bacteria RepID... 350 2e-95 UniRef50_B2W5W6 Porphobilinogen deaminase n=2 Tax=Pleosporineae ... 350 2e-95 UniRef50_UPI00006CBE06 porphobilinogen deaminase family protein ... 350 4e-95 UniRef50_C6WZF5 Porphobilinogen deaminase n=1 Tax=Flavobacteriac... 350 4e-95 UniRef50_A9FDP9 Porphobilinogen deaminase n=1 Tax=Sorangium cell... 349 6e-95 UniRef50_A3CL78 Porphobilinogen deaminase n=1 Tax=Streptococcus ... 347 2e-94 UniRef50_Q1V167 Hydroxymethylbilane synthase n=3 Tax=Candidatus ... 347 3e-94 UniRef50_A0LRF1 Porphobilinogen deaminase n=1 Tax=Acidothermus c... 347 4e-94 UniRef50_A2Q9P7 Catalytic activity: 4 porphobilinogen+H(2)O<=>hy... 345 9e-94 UniRef50_C0YV01 Hydroxymethylbilane synthase n=1 Tax=Chryseobact... 344 2e-93 UniRef50_Q0TQG4 Porphobilinogen deaminase n=32 Tax=Clostridium R... 344 2e-93 UniRef50_C3PNS9 Porphobilinogen deaminase n=15 Tax=Rickettsia Re... 343 4e-93 UniRef50_C1AA38 Porphobilinogen deaminase n=1 Tax=Gemmatimonas a... 343 5e-93 UniRef50_A8MDU3 Probable porphobilinogen deaminase n=2 Tax=Therm... 343 5e-93 UniRef50_C1ZK04 Porphobilinogen deaminase n=1 Tax=Planctomyces l... 342 8e-93 UniRef50_A3ZKX4 Porphobilinogen deaminase n=1 Tax=Blastopirellul... 342 1e-92 UniRef50_C4ZFT9 Porphobilinogen deaminase n=1 Tax=Eubacterium re... 342 1e-92 UniRef50_A5CDH4 Porphobilinogen deaminase n=2 Tax=Orientia tsuts... 340 3e-92 UniRef50_B3DZQ6 Porphobilinogen deaminase n=1 Tax=Methylacidiphi... 339 7e-92 UniRef50_B8MVK7 Porphobilinogen deaminase, putative n=1 Tax=Tala... 339 7e-92 UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia... 339 8e-92 UniRef50_Q0BX92 Porphobilinogen deaminase n=1 Tax=Hyphomonas nep... 338 1e-91 UniRef50_A2BL26 Probable porphobilinogen deaminase n=2 Tax=Therm... 338 1e-91 UniRef50_B5G8F1 Porphobilinogen deaminase n=1 Tax=Streptomyces s... 336 5e-91 UniRef50_A4XK06 Porphobilinogen deaminase n=2 Tax=Clostridia Rep... 336 5e-91 UniRef50_C7NFP7 Hydroxymethylbilane synthase n=7 Tax=Actinomycet... 335 8e-91 UniRef50_Q09899 Porphobilinogen deaminase n=2 Tax=Schizosaccharo... 335 8e-91 UniRef50_C8WIZ2 Porphobilinogen deaminase n=2 Tax=Coriobacteriac... 334 3e-90 UniRef50_A8SQW4 Putative uncharacterized protein n=1 Tax=Coproco... 334 3e-90 UniRef50_A8MGE4 Porphobilinogen deaminase n=30 Tax=cellular orga... 333 4e-90 UniRef50_B9XN63 Porphobilinogen deaminase n=1 Tax=bacterium Elli... 332 7e-90 UniRef50_A4QB59 Porphobilinogen deaminase n=15 Tax=Corynebacteri... 332 9e-90 UniRef50_Q82P95 Porphobilinogen deaminase 2 n=14 Tax=Actinomycet... 332 1e-89 UniRef50_C1F251 Hydroxymethylbilane synthase n=1 Tax=Acidobacter... 332 1e-89 UniRef50_Q8TXC8 Probable porphobilinogen deaminase n=1 Tax=Metha... 332 1e-89 UniRef50_A0DD68 Chromosome undetermined scaffold_46, whole genom... 331 2e-89 UniRef50_B8GXG1 Porphobilinogen deaminase n=8 Tax=Caulobacterace... 331 2e-89 UniRef50_B0D5Q2 Predicted protein n=1 Tax=Laccaria bicolor S238N... 331 2e-89 UniRef50_D0J8N1 Porphobilinogen deaminase n=2 Tax=Blattabacteriu... 331 2e-89 UniRef50_C6XKH7 Porphobilinogen deaminase n=1 Tax=Hirschia balti... 330 3e-89 UniRef50_B6W7F3 Putative uncharacterized protein n=1 Tax=Anaeroc... 330 5e-89 UniRef50_Q7UPN0 Porphobilinogen deaminase n=1 Tax=Rhodopirellula... 330 5e-89 UniRef50_B2IAW6 Porphobilinogen deaminase n=4 Tax=Alphaproteobac... 328 1e-88 UniRef50_Q46CH0 Probable porphobilinogen deaminase n=7 Tax=Eurya... 328 2e-88 UniRef50_C4QMG7 Hydroxymethylbilane synthase (Porphobilinogen de... 327 3e-88 UniRef50_C5RMN3 Porphobilinogen deaminase n=1 Tax=Clostridium ce... 327 4e-88 UniRef50_O29026 Probable porphobilinogen deaminase n=1 Tax=Archa... 327 4e-88 UniRef50_D1BFI8 Hydroxymethylbilane synthase n=4 Tax=Actinomycet... 327 5e-88 UniRef50_C2FZW8 Porphobilinogen deaminase n=2 Tax=Sphingobacteri... 326 6e-88 UniRef50_A4CHM3 Porphobilinogen deaminase n=4 Tax=Bacteroidetes ... 325 1e-87 UniRef50_B3RTQ8 Putative uncharacterized protein n=1 Tax=Trichop... 325 1e-87 UniRef50_Q47LA7 Porphobilinogen deaminase n=3 Tax=Actinomycetale... 324 2e-87 UniRef50_C9M5W1 Hydroxymethylbilane synthase n=1 Tax=Jonquetella... 324 2e-87 UniRef50_Q4T5L1 Chromosome undetermined SCAF9206, whole genome s... 324 3e-87 UniRef50_A8AAB4 Probable porphobilinogen deaminase n=1 Tax=Ignic... 324 3e-87 UniRef50_D2RH82 Porphobilinogen deaminase n=2 Tax=Archaeoglobace... 323 4e-87 UniRef50_C6XST0 Porphobilinogen deaminase n=2 Tax=Pedobacter Rep... 323 4e-87 UniRef50_A3MLK5 Porphobilinogen deaminase n=155 Tax=Proteobacter... 323 6e-87 UniRef50_D2NS36 Porphobilinogen deaminase n=2 Tax=Micrococcaceae... 322 1e-86 UniRef50_C1TM53 Porphobilinogen deaminase n=1 Tax=Dethiosulfovib... 322 1e-86 UniRef50_UPI000174444E Hydroxymethylbilane synthase n=1 Tax=Verr... 322 1e-86 UniRef50_C2GGB5 Porphobilinogen deaminase n=2 Tax=Corynebacteriu... 322 1e-86 UniRef50_D1VCA1 Porphobilinogen deaminase n=1 Tax=Frankia sp. Eu... 321 2e-86 UniRef50_A4WN24 Probable porphobilinogen deaminase n=3 Tax=Therm... 321 2e-86 UniRef50_Q2NEP4 HemC n=4 Tax=Methanobacteriaceae RepID=Q2NEP4_METST 320 3e-86 UniRef50_Q9F7M2 Predicted porphobilinogen deaminase n=2 Tax=Bact... 320 4e-86 UniRef50_C6R3Y0 Hydroxymethylbilane synthase n=1 Tax=Rothia muci... 319 7e-86 UniRef50_A0QLI0 Porphobilinogen deaminase n=69 Tax=Actinomycetal... 318 2e-85 UniRef50_Q8D2W2 HemC protein n=1 Tax=Wigglesworthia glossinidia ... 318 2e-85 UniRef50_C0BZ93 Putative uncharacterized protein n=1 Tax=Clostri... 318 2e-85 UniRef50_Q57989 Probable porphobilinogen deaminase n=11 Tax=Meth... 317 4e-85 UniRef50_A1DGB8 Porphobilinogen deaminase n=1 Tax=Neosartorya fi... 316 5e-85 UniRef50_UPI0001BC2D4C glutamyl-tRNA reductase n=1 Tax=Brevibact... 316 8e-85 UniRef50_D1C4S0 Porphobilinogen deaminase n=1 Tax=Sphaerobacter ... 315 9e-85 UniRef50_O26960 Probable porphobilinogen deaminase n=1 Tax=Metha... 315 1e-84 UniRef50_Q1EPC8 Porphobilinogen deaminase, chloroplast (Hydroxym... 315 1e-84 UniRef50_C5CB88 Porphobilinogen deaminase n=5 Tax=Actinomycetale... 314 2e-84 UniRef50_B6JII8 Porphobilinogen deaminase n=11 Tax=Bradyrhizobia... 313 6e-84 UniRef50_C9RPT6 Porphobilinogen deaminase n=1 Tax=Fibrobacter su... 312 9e-84 UniRef50_Q6AHF1 Porphobilinogen deaminase n=5 Tax=Actinobacteria... 310 3e-83 UniRef50_A3VPD5 Porphobilinogen deaminase n=1 Tax=Parvularcula b... 308 1e-82 UniRef50_A8PWJ5 Putative uncharacterized protein n=1 Tax=Malasse... 308 1e-82 UniRef50_C5EV71 Pyruvate ferredoxin/flavodoxin oxidoreductase n=... 308 2e-82 UniRef50_B2ULP1 Porphobilinogen deaminase n=1 Tax=Akkermansia mu... 306 8e-82 UniRef50_A2SQU4 Uroporphyrin-III C-methyltransferase n=11 Tax=Eu... 305 1e-81 UniRef50_A6LKX0 Porphobilinogen deaminase n=1 Tax=Thermosipho me... 305 2e-81 UniRef50_Q6L2G8 Probable porphobilinogen deaminase n=1 Tax=Picro... 304 3e-81 UniRef50_C7DH16 Porphobilinogen deaminase n=1 Tax=Candidatus Mic... 303 5e-81 UniRef50_C6V4N6 Porphobilinogen deaminase n=2 Tax=Neorickettsia ... 303 5e-81 UniRef50_B3LB83 Porphobilinogen deaminase, putative n=1 Tax=Plas... 303 7e-81 UniRef50_D1B7N1 Porphobilinogen deaminase n=1 Tax=Thermanaerovib... 303 7e-81 UniRef50_Q5KKQ0 Hydroxymethylbilane synthase, putative n=2 Tax=F... 302 2e-80 UniRef50_Q0ATQ1 Porphobilinogen deaminase n=3 Tax=Alphaproteobac... 302 2e-80 UniRef50_B5GJG2 Porphobilinogen deaminase n=3 Tax=Streptomyces R... 300 3e-80 UniRef50_C7M2H5 Porphobilinogen deaminase n=1 Tax=Acidimicrobium... 300 5e-80 UniRef50_Q1AUK3 Porphobilinogen deaminase n=1 Tax=Rubrobacter xy... 299 8e-80 UniRef50_A4YD92 Probable porphobilinogen deaminase n=1 Tax=Metal... 298 2e-79 UniRef50_C7R376 Porphobilinogen deaminase n=1 Tax=Jonesia denitr... 298 2e-79 UniRef50_D1JID7 Porphobilinogen deaminase n=1 Tax=uncultured arc... 297 3e-79 UniRef50_C4JRY9 Porphobilinogen deaminase n=1 Tax=Uncinocarpus r... 296 8e-79 UniRef50_A9HK97 Porphobilinogen deaminase n=12 Tax=Acetobacterac... 295 1e-78 UniRef50_B5JN62 Porphobilinogen deaminase n=1 Tax=Verrucomicrobi... 295 1e-78 UniRef50_Q2FTK7 Hydroxymethylbilane synthase n=3 Tax=Methanomicr... 293 4e-78 UniRef50_C3MZR8 Probable porphobilinogen deaminase n=11 Tax=Sulf... 293 5e-78 UniRef50_D2RNT2 Porphobilinogen deaminase n=1 Tax=Acidaminococcu... 292 8e-78 UniRef50_C0W553 Porphobilinogen deaminase n=2 Tax=Actinomycetale... 291 2e-77 UniRef50_Q4PFH9 Putative uncharacterized protein n=1 Tax=Ustilag... 291 3e-77 UniRef50_C8WDJ7 Porphobilinogen deaminase n=3 Tax=Zymomonas mobi... 285 1e-75 UniRef50_Q97B26 Probable porphobilinogen deaminase n=2 Tax=Therm... 284 3e-75 UniRef50_A2BFN7 Hydroxymethylbilane synthase (Fragment) n=6 Tax=... 283 4e-75 UniRef50_C1XV35 Porphobilinogen deaminase n=2 Tax=Meiothermus Re... 283 5e-75 UniRef50_C5C5B3 Porphobilinogen deaminase n=6 Tax=Actinomycetale... 282 1e-74 UniRef50_Q8I5V3 Porphobilinogen deaminase n=6 Tax=Plasmodium Rep... 281 2e-74 UniRef50_B4D5X7 Porphobilinogen deaminase n=1 Tax=Chthoniobacter... 281 2e-74 UniRef50_B0WMK9 Porphobilinogen deaminase n=1 Tax=Culex quinquef... 281 3e-74 UniRef50_Q93A65 Porphobilinogen deaminase n=1 Tax=uncultured bac... 280 4e-74 UniRef50_Q9Y9J0 Probable porphobilinogen deaminase n=1 Tax=Aerop... 280 4e-74 UniRef50_Q0RS16 Porphobilinogen deaminase 1 (PBG 1) (Hydroxymeth... 278 1e-73 UniRef50_Q1GP41 Porphobilinogen deaminase n=7 Tax=Sphingomonadal... 274 2e-72 UniRef50_Q83H95 Porphobilinogen deaminase n=2 Tax=Tropheryma whi... 271 3e-71 UniRef50_UPI000038E213 porphobilinogen deaminase n=1 Tax=Ferropl... 270 7e-71 UniRef50_A9V9E0 Predicted protein n=1 Tax=Monosiga brevicollis R... 268 2e-70 UniRef50_UPI0001C31A39 porphobilinogen deaminase n=1 Tax=Conexib... 262 1e-68 UniRef50_Q04X38 Bifunctional porphobilinogen deaminase/uroporphy... 262 1e-68 UniRef50_B0SF66 Bifunctional porphobilinogen deaminase/uroporphy... 261 2e-68 UniRef50_A7BMK1 Porphobilinogen deaminase n=1 Tax=Beggiatoa sp. ... 261 2e-68 UniRef50_A5K0J5 Porphobilinogen deaminase, putative n=1 Tax=Plas... 258 1e-67 UniRef50_B1ZV87 Porphobilinogen deaminase n=2 Tax=Opitutaceae Re... 254 4e-66 UniRef50_Q86ET2 Clone ZZD1450 mRNA sequence n=3 Tax=Schistosoma ... 243 7e-63 UniRef50_C0EAN0 Putative uncharacterized protein n=1 Tax=Clostri... 237 4e-61 UniRef50_Q6MHU0 Hydroxymethylbilane synthase n=1 Tax=Bdellovibri... 235 1e-60 UniRef50_Q4E9D5 Porphobilinogen deaminase (Fragment) n=1 Tax=Wol... 233 8e-60 UniRef50_B6YQR9 Hydroxymethylbilane synthase/uroporphyrin-III C-... 225 2e-57 UniRef50_Q6MEK3 Putative Porphobilinogen deaminase n=2 Tax=Parac... 224 3e-57 UniRef50_B4UXX3 Porphobilinogen deaminase 2 (Fragment) n=1 Tax=S... 223 8e-57 UniRef50_A8I2X7 Porphobilinogen deaminase n=1 Tax=Chlamydomonas ... 218 1e-55 UniRef50_Q6Q923 Predicted porphobilinogen deaminase n=2 Tax=envi... 210 5e-53 UniRef50_Q9PK95 Probable porphobilinogen deaminase n=13 Tax=Chla... 207 3e-52 UniRef50_D0RNS6 Putative porphobilinogen deaminase (Pbg)(Hydroxy... 203 6e-51 UniRef50_C5LJF7 Porphobilinogen deaminase, putative n=5 Tax=Perk... 200 4e-50 UniRef50_Q9HMY5 Probable porphobilinogen deaminase n=2 Tax=Halob... 196 1e-48 UniRef50_Q18ES3 Hydroxymethylbilane synthase (Porphobilinogen de... 181 2e-44 UniRef50_UPI000155526F PREDICTED: similar to hydroxymethylbilane... 166 1e-39 UniRef50_B0KCR7 Porphobilinogen deaminase n=3 Tax=Thermoanaeroba... 161 3e-38 UniRef50_C0DZX9 Putative uncharacterized protein n=1 Tax=Coryneb... 154 3e-36 UniRef50_UPI0001B4213A porphobilinogen deaminase n=1 Tax=Listeri... 144 3e-33 UniRef50_A8CBG6 Porphobilinogen deaminase n=3 Tax=Toxoplasma gon... 143 8e-33 UniRef50_UPI0001742E92 Porphobilinogen deaminase n=1 Tax=candida... 133 1e-29 UniRef50_C4Z1K5 Putative uncharacterized protein n=1 Tax=Eubacte... 126 1e-27 UniRef50_Q401C3 Hydroxymethylbilane synthase (Fragment) n=7 Tax=... 124 6e-27 UniRef50_UPI0001698669 porphobilinogen deaminase n=1 Tax=Endorif... 120 5e-26 UniRef50_Q1HRH6 Hydroxymethylbilane synthase-like protein n=1 Ta... 118 2e-25 UniRef50_C5G109 Porphobilinogen deaminase n=1 Tax=Microsporum ca... 112 2e-23 UniRef50_B8N6H4 Putative uncharacterized protein n=1 Tax=Aspergi... 100 6e-20 UniRef50_UPI0000D9FBB5 PREDICTED: similar to lethal (3) 02640 CG... 100 1e-19 UniRef50_UPI0001C35DE1 porphobilinogen deaminase n=1 Tax=Clostri... 89 2e-16 UniRef50_C5U771 Porphobilinogen deaminase n=1 Tax=Methanocaldoco... 74 9e-12 UniRef50_Q4EB45 Porphobilinogen deaminase n=1 Tax=Wolbachia endo... 63 1e-08 UniRef50_B5XH53 Porphobilinogen deaminase n=1 Tax=Salmo salar Re... 60 1e-07 UniRef50_C2BR76 Putative uncharacterized protein (Fragment) n=1 ... 59 2e-07 Sequences not found previously or not previously below threshold: UniRef50_UPI0000D537E6 hypothetical protein P700755_22735 n=1 Ta... 55 3e-06 >UniRef50_B7LU53 Porphobilinogen deaminase n=87 Tax=cellular organisms RepID=HEM3_ESCF3 Length = 313 Score = 447 bits (1151), Expect = e-124, Method: Composition-based stats. Identities = 296/312 (94%), Positives = 302/312 (96%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 MLDNVLRIATRQSPLALWQAHYVKD LMA HPGL VELVPMVTRGDVILDTPLAKVGGKG Sbjct: 1 MLDNVLRIATRQSPLALWQAHYVKDALMAKHPGLTVELVPMVTRGDVILDTPLAKVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN Y SLD LP Sbjct: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNKYASLDELP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE Sbjct: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 SRIR ALPPE+SLPAVGQGAVGIECRLDD+RTRELLAALNH ETALRVTAERAMNTRLEG Sbjct: 181 SRIRDALPPEVSLPAVGQGAVGIECRLDDTRTRELLAALNHPETALRVTAERAMNTRLEG 240 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPIGSYAELI GEIWLRALVGAPDGSQ+IRGERRG+PQDAE+MGISLAEELLNNGAR Sbjct: 241 GCQVPIGSYAELIGGEIWLRALVGAPDGSQMIRGERRGSPQDAEKMGISLAEELLNNGAR 300 Query: 301 EILAEVYNGDAP 312 ILA+VYNGDAP Sbjct: 301 AILADVYNGDAP 312 >UniRef50_B5FN93 Porphobilinogen deaminase n=168 Tax=cellular organisms RepID=HEM3_SALDC Length = 313 Score = 440 bits (1133), Expect = e-122, Method: Composition-based stats. Identities = 279/313 (89%), Positives = 294/313 (93%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 MLDNVLRIATRQSPLALWQAHYVKD LMA+HPGL VELVPMVTRGDVILDTPLAKVGGKG Sbjct: 1 MLDNVLRIATRQSPLALWQAHYVKDALMATHPGLTVELVPMVTRGDVILDTPLAKVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKELE+ALLE RADIAVHSMKDVPV FP GLGLVTICEREDPRDAFVSN Y SLD LP Sbjct: 61 LFVKELEIALLEKRADIAVHSMKDVPVAFPDGLGLVTICEREDPRDAFVSNKYHSLDDLP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRL KLDNG+YDAIILAVAGLKRLGLE Sbjct: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLGKLDNGDYDAIILAVAGLKRLGLE 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 SRIR ALPP++SLPAVGQGAVGIECRLDD+RT+ LLA LNH +TALRVTAERAMNTRLEG Sbjct: 181 SRIRTALPPDVSLPAVGQGAVGIECRLDDARTQALLAPLNHSQTALRVTAERAMNTRLEG 240 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPIGSYAE+I+GEIWLRALVGAPDGS ++RGERRG+P+ AEQMGISLAEELL NGAR Sbjct: 241 GCQVPIGSYAEIINGEIWLRALVGAPDGSVMVRGERRGSPEQAEQMGISLAEELLENGAR 300 Query: 301 EILAEVYNGDAPA 313 IL EVYNG+ PA Sbjct: 301 AILTEVYNGETPA 313 >UniRef50_Q3ACT3 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=HEM3_CARHZ Length = 311 Score = 436 bits (1123), Expect = e-121, Method: Composition-based stats. Identities = 146/310 (47%), Positives = 202/310 (65%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + + + +R S LALWQ ++V ++L HP + ++V M T+GD ILD LAK+G KGL Sbjct: 1 MKKEVIVGSRDSALALWQTNWVVERLSKIHPEINFKIVTMKTKGDKILDVALAKIGDKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F KELE ALL D+AVHSMKD+P P+GL + CERE P D F+S LP Sbjct: 61 FTKELEHALLNKTIDMAVHSMKDLPTVLPEGLKIGAFCEREYPGDVFISPKGFKFLELPQ 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ +GTSSLRR Q+ RPDL LRGN+ TR K++ + D IILA AG+KRLG E Sbjct: 121 GARIGTSSLRRIAQILAVRPDLQAIPLRGNLPTRFRKMEEMDLDGIILAYAGVKRLGYED 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 +I L ++ LPAVGQG++G+E R DD+ ELL ++H T + AERA RLEGG Sbjct: 181 KITEMLSFDLCLPAVGQGSIGVEIRADDTFIEELLKPIDHFATNRAIRAERAFLKRLEGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 CQ+PIG+Y+E+ + + L+ +V + DG +I+GE+ G+ ++ E++GISLAEELL GA++ Sbjct: 241 CQIPIGAYSEVKENRLHLKGVVASLDGKLVIKGEKEGSIEEPEKVGISLAEELLTKGAQK 300 Query: 302 ILAEVYNGDA 311 IL E+ Sbjct: 301 ILEEIRRDAN 310 >UniRef50_C0QU69 Porphobilinogen deaminase n=4 Tax=Bacteria RepID=C0QU69_PERMH Length = 308 Score = 435 bits (1119), Expect = e-120, Method: Composition-based stats. Identities = 171/306 (55%), Positives = 229/306 (74%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR+S LALWQA+Y+ D+L P L VELV +VT+GD ILD PLAKVGGKGLFVKE Sbjct: 3 IRIGTRKSKLALWQANYIADQLKKHFPDLEVELVKIVTKGDKILDVPLAKVGGKGLFVKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E A+L N DIAVHS+KDVP FP+GLGLV I EREDPRDAF+S Y+S++ +P G+++ Sbjct: 63 IEEAMLRNEIDIAVHSLKDVPTYFPEGLGLVAITEREDPRDAFLSVKYNSIEDMPEGAVL 122 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR+ Q+ +R D+ I LRGNV TR+ KL+ G+YD IILA AGLKRLGLE ++R Sbjct: 123 GTSSLRRKAQIMMKRKDIRIEDLRGNVDTRIRKLEEGQYDGIILAYAGLKRLGLEGKVRQ 182 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L P+ +PAV QG +GIE RLDD +TRE+++ LNH E+ +R AERA LEGGCQVP Sbjct: 183 ILQPDYMIPAVAQGFLGIEARLDDEKTREIVSVLNHRESEIRAKAERAFLKTLEGGCQVP 242 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 + Y+E+++G++ + V G ++ R G+ +DAE +G+ LAE+LL++GA+E+L E Sbjct: 243 LAGYSEIVNGKLKITGFVSDLTGDRVFRDSMEGSLEDAESLGVKLAEKLLSDGAKEVLEE 302 Query: 306 VYNGDA 311 +Y+G Sbjct: 303 IYSGSE 308 >UniRef50_B5YJZ4 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=B5YJZ4_THEYD Length = 311 Score = 429 bits (1104), Expect = e-119, Method: Composition-based stats. Identities = 157/309 (50%), Positives = 219/309 (70%), Gaps = 1/309 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 + N + I +R S LA+WQA++VKDKL +P L VE+ + T GD ILD PLAK+GGKG Sbjct: 3 VKRNKIVIGSRGSKLAMWQANWVKDKLQTLYPELKVEIEKIKTTGDKILDAPLAKIGGKG 62 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E ALL R D+AVHSMKDVP E P+GL + ICEREDPRDAF+S + L+ LP Sbjct: 63 LFVKEIEEALLSKRVDLAVHSMKDVPTEIPEGLQISAICEREDPRDAFISKDGVLLNELP 122 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 +++GTSSLRR QL R DL+I+ LRGNV TR+ KL +GE+ AI+LA+AG+KR+G+E Sbjct: 123 QEAVLGTSSLRRTVQLKALRNDLVIKPLRGNVDTRIRKLKDGEFQAIVLAMAGVKRMGVE 182 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 + + A ++ +PA+GQGA+GIE R+DD EL+ LNH ETA+ + AERA + + G Sbjct: 183 NLVTQAFSEDLMIPAIGQGAIGIETRVDDDFVNELIKPLNHEETAICILAERAFLSVMGG 242 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQ-IIRGERRGAPQDAEQMGISLAEELLNNGA 299 GCQVP+ +A +++ + + ++G P+G +I+G R G+ A+ +G+ LA ELL+ G Sbjct: 243 GCQVPLACHARIVNNSLKIVGMIGDPEGKMPVIKGFREGSLSQAQSLGVELANELLHRGG 302 Query: 300 REILAEVYN 308 +EIL +VY Sbjct: 303 KEILEKVYK 311 >UniRef50_C0Q9U2 HemC n=2 Tax=Bacteria RepID=C0Q9U2_DESAH Length = 325 Score = 428 bits (1101), Expect = e-118, Method: Composition-based stats. Identities = 146/307 (47%), Positives = 199/307 (64%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + ++I TR S LALWQA++VKD++ P VE++ + T GD+I+D PL+ VGGKGL Sbjct: 19 MKKTIKIGTRGSKLALWQANHVKDRIEDQFPETEVEIMTIKTTGDMIVDRPLSMVGGKGL 78 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKE+E ALLE+ D+AVHSMKD+P E P GL + + RE+P D +SNN SL LP Sbjct: 79 FVKEIEKALLESTIDMAVHSMKDMPGELPPGLVIGAVPARENPFDVLISNNNLSLADLPK 138 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ +GTSSLRR Q+ RPD+ S+RGN+ TRL KL GE+DA +LA AGL RLG+++ Sbjct: 139 GARIGTSSLRRASQIKHARPDIETASIRGNLDTRLKKLAAGEFDATLLAAAGLIRLGMKT 198 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 I I +PAVGQGA+ IE R +D +LA LNH ET V+ ERA RL+G Sbjct: 199 VITQYFDETIMIPAVGQGALCIESRQEDLDIAPVLAFLNHGETHTVVSGERAFLRRLDGS 258 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 C +P+ + L D + L LV + DG I++ G P+D ++ GI+LAE LL+ GA + Sbjct: 259 CHIPVACFGRLEDHRVILTGLVASEDGRTILKETVAGTPEDPQKAGIALAETLLSKGADK 318 Query: 302 ILAEVYN 308 IL + + Sbjct: 319 ILENLNS 325 >UniRef50_Q8YVU6 Porphobilinogen deaminase n=50 Tax=cellular organisms RepID=HEM3_ANASP Length = 323 Score = 423 bits (1088), Expect = e-117, Method: Composition-based stats. Identities = 151/308 (49%), Positives = 199/308 (64%), Gaps = 3/308 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +RI +R+S LAL Q ++V+++L S P + E+ M T+GD ILD LAK+G KGLF Sbjct: 10 RTIRIGSRKSQLALVQTYWVREQLQNSFPDINFEVHTMSTQGDKILDVALAKIGDKGLFT 69 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALP 120 KELEV ++ D AVHS+KD+P P+GL L I ERE+P DA V + +D LP Sbjct: 70 KELEVGMINEEIDFAVHSLKDLPTNLPEGLALAAITERENPADALVVHENFKDKQIDTLP 129 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 AG+++GTSSLRR QL + P L + +RGN+ TRL+KLD GEYD +ILA AGL+RLG+ Sbjct: 130 AGAVIGTSSLRRLAQLRNQFPHLTFKDVRGNLNTRLAKLDAGEYDGLILAAAGLQRLGMG 189 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R+ LP EISL AVGQGA+GIECR DD+ +L A+ H ET R AER+ LEG Sbjct: 190 DRVHQILPKEISLHAVGQGALGIECRADDAELITVLKAIEHPETRDRCLAERSFLRSLEG 249 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPIG E+ E+ L +V + DG +++ G DAE +GI LAE L GA+ Sbjct: 250 GCQVPIGVNTEINGNELILTGVVASVDGQNLVKDTVSGNASDAEAIGIRLAELLREQGAQ 309 Query: 301 EILAEVYN 308 EIL ++ Sbjct: 310 EILNTIFA 317 >UniRef50_D1BNZ5 Porphobilinogen deaminase n=3 Tax=Veillonella RepID=D1BNZ5_VEIPT Length = 312 Score = 422 bits (1087), Expect = e-117, Method: Composition-based stats. Identities = 144/309 (46%), Positives = 195/309 (63%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + + +RI TR+S LALWQA ++ +L +P + VELV T+GD IL+ PLA+VGGKGL Sbjct: 1 MRDHIRIGTRKSALALWQAEHISAELQRLYPNITVELVHFNTKGDRILEKPLAQVGGKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F ELE A+ DIAVHS+KD+P E P+GL L I RE P DA VS Y +LD LP Sbjct: 61 FTAELEEAMHAGDIDIAVHSLKDMPTELPEGLTLGAISAREVPYDALVSPVYKTLDKLPQ 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ VGTSSLRRQ QL RPDL + +RGNV TRLSK++ + D +ILA AGLKRLGLE Sbjct: 121 GARVGTSSLRRQAQLLHVRPDLKVEVIRGNVQTRLSKIETEKLDGVILAQAGLKRLGLED 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 +I + +PAVGQGA+ IECR DD+ ++L +N T V ER+ +L GG Sbjct: 181 QITQVFKADEMIPAVGQGALAIECRADDTEMLDMLDPINDEATRYAVEGERSFLRQLNGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 CQVP+G + + G++ L+A++ + DG + GE G + E +G +LA+ L G + Sbjct: 241 CQVPMGVHGTINKGQLTLKAMIASLDGKTVYEGEISGPAKKGEILGKNLAKALYEEGGKR 300 Query: 302 ILAEVYNGD 310 I+ + Sbjct: 301 IVDALIEEG 309 >UniRef50_Q8DIE4 Porphobilinogen deaminase n=11 Tax=cellular organisms RepID=HEM3_THEEB Length = 320 Score = 419 bits (1077), Expect = e-116, Method: Composition-based stats. Identities = 151/314 (48%), Positives = 199/314 (63%), Gaps = 3/314 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 +RI +R+S LAL Q +V+ +L H E+V M T+GD ILD LAK+G KGL Sbjct: 5 SSRPVRIGSRKSQLALVQTEWVQAQLQTHHRDRAFEVVTMTTQGDNILDVALAKIGDKGL 64 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDA 118 F KELE+++L D+AVHS+KD+P + P GL L I EREDP DA V ++D Sbjct: 65 FTKELELSMLRGETDLAVHSLKDLPTQLPDGLVLAAITEREDPADALVLGAKWTGHTIDT 124 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 LP G+++GTSSLRR QL P L + +RGN+ TRL+KLD GEYDA+ILAVAGL+RLG Sbjct: 125 LPEGTVIGTSSLRRLAQLRHYYPHLTFKDVRGNLNTRLAKLDAGEYDALILAVAGLRRLG 184 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 RI LP +SL AVGQGA+GIECR +D+ L+ L H ET R AERA +L Sbjct: 185 FGDRISQVLPATVSLYAVGQGALGIECRAEDADILALVKTLEHPETTARCLAERAFLRQL 244 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 EGGCQVPIG + + +G++ L LV + DG ++++ G AE++G LA +L G Sbjct: 245 EGGCQVPIGVHTVIENGQLTLTGLVASLDGQRLVKDSLTGDVATAEELGTRLALKLREQG 304 Query: 299 AREILAEVYNGDAP 312 A EIL E++ P Sbjct: 305 ASEILEEIFATVRP 318 >UniRef50_Q0I178 Porphobilinogen deaminase n=45 Tax=Bacteria RepID=HEM3_HAES1 Length = 321 Score = 415 bits (1068), Expect = e-115, Method: Composition-based stats. Identities = 199/317 (62%), Positives = 235/317 (74%), Gaps = 11/317 (3%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + L+IATRQSPLALWQA+YVK++L + L VELVP++T+GDVILDTPLAK+GGKGLF Sbjct: 4 NKTLKIATRQSPLALWQANYVKNRLQQRYSHLSVELVPIITKGDVILDTPLAKIGGKGLF 63 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 VKELE ALL ADIAVHSMKDVP++FP+GL L IC REDPRDAFVSN Y +LD LP G Sbjct: 64 VKELENALLNGEADIAVHSMKDVPMQFPKGLELSVICPREDPRDAFVSNKYRTLDELPQG 123 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 +IVGTSSLRRQCQL R DL IRSLRGNVGTRL+KLD G+YDAIILA AGL RLGL R Sbjct: 124 AIVGTSSLRRQCQLKNWRADLDIRSLRGNVGTRLNKLDQGDYDAIILASAGLIRLGLTER 183 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 IR+ + + LPA GQGAVGIECR+DD + LL L T V AERAMN L+GGC Sbjct: 184 IRSFIEIDTILPACGQGAVGIECRVDDRDVQSLLMPLADQTTTYCVLAERAMNFHLQGGC 243 Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE-----------RRGAPQDAEQMGISLA 291 QVPIG+YA L + +++LR LVG GSQI+ E + A Q AE++G+S+A Sbjct: 244 QVPIGAYAILENNQLYLRGLVGDVHGSQILSAEGQFELSLDFESSQSAVQKAEELGVSIA 303 Query: 292 EELLNNGAREILAEVYN 308 E+LL GA +IL VY Sbjct: 304 EQLLQQGADKILQAVYQ 320 >UniRef50_Q65GK1 Porphobilinogen deaminase n=98 Tax=Bacillales RepID=HEM3_BACLD Length = 313 Score = 414 bits (1066), Expect = e-114, Method: Composition-based stats. Identities = 143/307 (46%), Positives = 188/307 (61%), Gaps = 4/307 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 + + +R+S LA+ Q +V KL +P E+ +VT+GD ILD L+KVGGKGLFV Sbjct: 2 RNIIVGSRRSKLAMTQTKWVIKKLEELNPDFTFEIKEIVTKGDRILDVTLSKVGGKGLFV 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE+E A+L D+AVHSMKD+P P+GL + I +RED RD +S L L G+ Sbjct: 62 KEIEQAMLSGEIDMAVHSMKDMPSVLPEGLMVGCIPKREDARDVLISKGRQKLADLKQGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL-ESR 182 +VGTSSLRR QL + RPDL I+ +RGN+ TRL KL+ +YDAIILA AGL R+G + Sbjct: 122 VVGTSSLRRSAQLLQMRPDLEIKWIRGNIDTRLKKLETEDYDAIILAAAGLSRMGWKDDV 181 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 + L PE LPAVGQGA+ IECR D L + LN T L VTAERA +EGGC Sbjct: 182 VTEFLDPESCLPAVGQGALAIECRGSDEELLSLFSRLNDRYTQLTVTAERAFLHAMEGGC 241 Query: 243 QVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 QVPI +A++ DG I L LV +PDG + R +G +D E +G A + GA+ Sbjct: 242 QVPIAGFAKMDEDGVIELTGLVASPDGKTVYRETVKG--KDPEAVGRECAAVMSEKGAKA 299 Query: 302 ILAEVYN 308 ++ V Sbjct: 300 LIDRVKQ 306 >UniRef50_A1AUE7 Porphobilinogen deaminase n=44 Tax=Bacteria RepID=HEM3_PELPD Length = 310 Score = 413 bits (1062), Expect = e-114, Method: Composition-based stats. Identities = 167/310 (53%), Positives = 204/310 (65%), Gaps = 1/310 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M LRI TR S LALWQA++VK +L +P + V L + T GD ILD PLA+VGGKG Sbjct: 1 MPPRQLRIGTRASQLALWQANWVKSELEKRYPAMEVTLTKIKTMGDRILDVPLAQVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E A+L DIAVHSMKDVP EFP+GLGL I EREDPRDA VS LP Sbjct: 61 LFVKEIEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVVSR-AARFSHLP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGTS+LRRQ QL RPDL + ++RGNV TR+ KLD DA+ILA AGLKRLGL Sbjct: 120 PGARVGTSALRRQAQLLHARPDLEMVTIRGNVETRIRKLDEENLDAVILAAAGLKRLGLT 179 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R+ L E S+PA+GQGA+GIECRL D E +A NH +T+ V AERA+ R +G Sbjct: 180 QRVAEYLDVEFSIPAIGQGALGIECRLSDPVVTEAIAFFNHPDTSHAVRAERALLRRCQG 239 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPI ++ + GE+ L L+ A DG + +R E G E +G LA+ LL+ G R Sbjct: 240 GCQVPIAAHGTIRGGELRLVGLIAAVDGREFVRDEISGPVDQCEHLGEELADRLLSRGGR 299 Query: 301 EILAEVYNGD 310 IL EVY + Sbjct: 300 AILEEVYQRE 309 >UniRef50_B5EBG8 Porphobilinogen deaminase n=166 Tax=Bacteria RepID=HEM3_GEOBB Length = 318 Score = 411 bits (1058), Expect = e-113, Method: Composition-based stats. Identities = 158/310 (50%), Positives = 205/310 (66%), Gaps = 1/310 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M LRI TR S LALWQA++VK +L +P + V L + T GD ILD PLA+VGGKG Sbjct: 1 MALKELRIGTRASQLALWQANWVKSELEKRYPDMTVTLTKIKTIGDKILDVPLAQVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E A+L DIAVHSMKDVP EFP+GLGL I EREDPRDA +SN LP Sbjct: 61 LFVKEIEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVISN-GVKFADLP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GTS+LRRQ QL + RPDL + +RGNV TR+ KL DA+ILA AGL RLG Sbjct: 120 QGARIGTSALRRQAQLLKVRPDLEMVIIRGNVQTRMDKLKTEGLDAVILAAAGLNRLGFA 179 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 +I LP ++SLPA+GQGA+GIEC L + ++ ++ N +T+ V AERA+ R EG Sbjct: 180 DQITEMLPTDLSLPAIGQGALGIECNLSNQDVKDAISFFNSPDTSRAVRAERALLWRCEG 239 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPI ++ E+ ++ L + + DG ++G G D E++G+ LAE+LL+ G Sbjct: 240 GCQVPIAAFGEVTGDQLKLTGFIASVDGKVSVKGVVTGPADDCEKLGVKLAEQLLSEGGH 299 Query: 301 EILAEVYNGD 310 ILAEVY + Sbjct: 300 AILAEVYQRE 309 >UniRef50_A6TJD5 Porphobilinogen deaminase n=2 Tax=Firmicutes RepID=HEM3_ALKMQ Length = 316 Score = 410 bits (1054), Expect = e-113, Method: Composition-based stats. Identities = 139/308 (45%), Positives = 191/308 (62%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 ++I +R S LAL QA + + L P E++ + T GD ILD L K+GGKGLFV Sbjct: 2 RTIKIGSRASQLALVQAEIIINMLKEKFPQYTYEIIKITTLGDRILDKTLDKIGGKGLFV 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE++ AL E + D+A+HSMKD+P E P+ L L I +REDPRD ++ SL+ LP G+ Sbjct: 62 KEIQKALAEEKIDLAIHSMKDMPGETPEELVLGAITKREDPRDVLITRENKSLEELPKGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 ++G+SSLRRQ Q+ R D+ + +RGNVGTRL K++ D +ILA AGL RLGL+ +I Sbjct: 122 VIGSSSLRRQAQVMALRGDIKVVPIRGNVGTRLGKIETESLDGVILAAAGLNRLGLKEKI 181 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + L E PAVGQGA+G E R D E+L A+NH ET V AERA LEGGC Sbjct: 182 SSYLEIEDFTPAVGQGALGCEARRKDIEMLEMLLAINHEETYRCVMAERAFLKLLEGGCH 241 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 VPIG+Y + E+ + +V + DG ++I+ + G D + +GI L E L+ GA+EIL Sbjct: 242 VPIGAYGQQQGQELHMTGMVASSDGRRVIKEQVMGDIADFQALGIQLGETLIEKGAKEIL 301 Query: 304 AEVYNGDA 311 V + Sbjct: 302 ETVNTDNR 309 >UniRef50_C9KL85 Hydroxymethylbilane synthase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KL85_9FIRM Length = 315 Score = 409 bits (1051), Expect = e-113, Method: Composition-based stats. Identities = 162/307 (52%), Positives = 201/307 (65%), Gaps = 1/307 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M ++ + I TR S LALWQA YV D L +P L VE M T+GD ILD PLAK+GGKG Sbjct: 1 MKNDTIVIGTRSSKLALWQADYVADCLRKRYPELRVEKKLMTTKGDKILDAPLAKIGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF KELE +L DIAVHS+KD+P E P+GL + I ER DP DA VS Y +L+ LP Sbjct: 61 LFTKELEQDMLAGGIDIAVHSLKDMPTEVPEGLVISAITERFDPGDAVVSPKYRTLENLP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGTSSLRR+ QL RPDL I LRGNV TRL KL+ +DAIILAVAGLKRLG Sbjct: 121 QGAKVGTSSLRRKAQLLHARPDLQISDLRGNVNTRLEKLEREHFDAIILAVAGLKRLGFA 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 RI LP E+ LPAVGQGA+ IE R +D R L+A LN T AERA R+EG Sbjct: 181 DRITEVLPREMVLPAVGQGALAIETRENDREVRNLIAFLNDEATVACARAERAFLARVEG 240 Query: 241 GCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GCQVP+G YA +G + + A++ + DG+++ R G+ +AE +G +LA++LL G Sbjct: 241 GCQVPVGVYAVPEAEGRLHVEAVIASLDGARLYRDAAVGSAAEAESLGTALADKLLAMGG 300 Query: 300 REILAEV 306 IL E+ Sbjct: 301 IAILHEI 307 >UniRef50_Q31PM2 Porphobilinogen deaminase n=8 Tax=cellular organisms RepID=HEM3_SYNE7 Length = 320 Score = 406 bits (1045), Expect = e-112, Method: Composition-based stats. Identities = 151/312 (48%), Positives = 200/312 (64%), Gaps = 3/312 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +RI +R+S LAL Q H+V+ +L +P ++ M T+GD+ILD LAK+G KGLF Sbjct: 7 RPIRIGSRKSQLALVQTHWVQGELQRLYPDRQFDVQTMSTQGDIILDVALAKIGDKGLFT 66 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALP 120 KELEVA+L D AVHS+KD+P P+GL L + EREDP DA V + L+ LP Sbjct: 67 KELEVAMLAGEVDFAVHSLKDLPTRLPEGLILGCVTEREDPADALVVHDRFKDHQLETLP 126 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+++GTSSLRR QL P L + +RGN+ TRL+KLD GEYDA+ILA AGL+RL + Sbjct: 127 EGTVIGTSSLRRLAQLRHHYPHLQFKDVRGNLNTRLAKLDAGEYDALILAAAGLQRLSMA 186 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 RI +P +SL AVGQGA+GIECR +D ELL AL H T+ R AERA LEG Sbjct: 187 DRIHQLIPAAVSLHAVGQGALGIECRAEDPEILELLKALEHEPTSQRCLAERAFLRELEG 246 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPIG + DG + L +V + DG +++R + G D E +G++LA +L GA+ Sbjct: 247 GCQVPIGVNTAIADGTLTLTGMVASLDGQRLLRDQVSGPTSDPEALGLALAAQLKAQGAK 306 Query: 301 EILAEVYNGDAP 312 EIL E++ P Sbjct: 307 EILDEIFATVRP 318 >UniRef50_C6HUG2 Porphobilinogen deaminase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HUG2_9BACT Length = 321 Score = 402 bits (1033), Expect = e-110, Method: Composition-based stats. Identities = 156/305 (51%), Positives = 205/305 (67%), Gaps = 2/305 (0%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + +RI TR S LALWQA +V + GL EL + T GD+IL PL++VGGKGLF Sbjct: 7 SSPIRIGTRGSELALWQARHVAAMIR-HTAGLESELTIIKTTGDMILSVPLSQVGGKGLF 65 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 VKE+E AL+ D+AVHSMKDVP P+GL + I REDPRDAFVSN Y S +LP G Sbjct: 66 VKEIEEALIAGTIDLAVHSMKDVPAFLPEGLEIGAILSREDPRDAFVSNAYSSFSSLPPG 125 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 + +GTSSLRR QL +RRPDL SLRGNVGTRL KLD + DAIILA AGL RLG R Sbjct: 126 ARIGTSSLRRMAQLKKRRPDLRFESLRGNVGTRLRKLDENQIDAIILAAAGLIRLGFSDR 185 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 IR LP E+SLPAVGQGA+G+ECR D R R +LA ++ ET V AER + + L+GGC Sbjct: 186 IREYLPVELSLPAVGQGALGLECRTGDHRIRTILARMHDPETTACVLAERGVLSALDGGC 245 Query: 243 QVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 Q+PI ++A + +I L A + +G+ ++ G ++A ++G+ A++LL+ G ++ Sbjct: 246 QLPIAAHARTISPEQIELIARILDVEGTTLLEEHTSGPAKEAHRLGVEAAQKLLSRGGQK 305 Query: 302 ILAEV 306 IL ++ Sbjct: 306 ILTDI 310 >UniRef50_Q5ZRY6 Porphobilinogen deaminase n=6 Tax=Legionella RepID=HEM3_LEGPH Length = 309 Score = 399 bits (1025), Expect = e-110, Method: Composition-based stats. Identities = 153/309 (49%), Positives = 205/309 (66%), Gaps = 1/309 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M ++RIATRQSPLALWQA++V++ L+ P L +EL+PM+T GD L L GGKG Sbjct: 1 MSAKIIRIATRQSPLALWQANHVREMLVKQWPNLSIELLPMITSGDRFLKDKLLSAGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKELE ALL+ RAD+AVHS KD+P + P GL L IC+R++P DA +S + SL ALP Sbjct: 61 LFVKELEEALLDKRADLAVHSTKDMPAQLPDGLLLTAICKRDNPFDALISPQFKSLAALP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 +I+GTSSLRRQ QL P+L I++LRGN+ TRLSKL++GEY AIILA AGL+R+GL Sbjct: 121 KNAIIGTSSLRRQSQLLAYNPNLQIKTLRGNIHTRLSKLESGEYQAIILAAAGLERMGLA 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 I +P +I LP QGA+ IECR DD +EL+ LN +AL V ER +N +L G Sbjct: 181 HHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELVHGLNDPISALCVHTERRVNAKLGG 240 Query: 241 GCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 C +P Y + + + + LRA V DGSQ+I E++G +AE + E L+ GA Sbjct: 241 NCHIPFAVYCTITEEKLLLLRAKVLNMDGSQMIDDEQQGKIAEAEVIADRCTESLMTKGA 300 Query: 300 REILAEVYN 308 +L+ + + Sbjct: 301 MSLLSTIPS 309 >UniRef50_Q2RJ26 Porphobilinogen deaminase n=5 Tax=Clostridia RepID=HEM3_MOOTA Length = 313 Score = 397 bits (1020), Expect = e-109, Method: Composition-based stats. Identities = 150/303 (49%), Positives = 193/303 (63%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +++ +R+S LA WQA +V L + PGL LV + T+GD ILD LA++G KGLF KE Sbjct: 4 IKVGSRESELARWQARWVIQALEKAWPGLSCRLVTLKTKGDKILDVALARIGDKGLFTKE 63 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE+ALL+ D+AVHSMKD+P P+GL + I REDP D VS +L LP + V Sbjct: 64 LELALLDGAIDLAVHSMKDMPTTLPEGLVIGAIGPREDPADVLVSPEGYTLATLPIKARV 123 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR+ QLA RPDL + LRGNV TRL+K++ AI+LA AGLKRL + Sbjct: 124 GTSSLRRKAQLAYARPDLELVDLRGNVPTRLAKMERDGLTAIVLAAAGLKRLNHGQVLGE 183 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 +P I LPAVGQGA+G+E R D R EL+AA+NH TA V AERA LEGGCQVP Sbjct: 184 PIPYHICLPAVGQGAIGVEIRAGDRRVAELVAAINHPPTAAAVRAERAYLRALEGGCQVP 243 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 I + A + D + L+ +V + DG +++R G+ +D E G LA +LL GA EIL E Sbjct: 244 IAALATVEDTALVLQGMVASLDGREMLRDIASGSTRDPEAAGRELARKLLARGAGEILQE 303 Query: 306 VYN 308 V Sbjct: 304 VKA 306 >UniRef50_P08397 Porphobilinogen deaminase n=59 Tax=Chordata RepID=HEM3_HUMAN Length = 361 Score = 394 bits (1012), Expect = e-108, Method: Composition-based stats. Identities = 145/340 (42%), Positives = 192/340 (56%), Gaps = 33/340 (9%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 V+R+ TR+S LA Q V L AS+PGL E++ M T GD ILDT L+K+G K LF Sbjct: 19 RVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFT 78 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALP 120 KELE AL +N D+ VHS+KD+P P G + IC+RE+P DA V + +L+ LP Sbjct: 79 KELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLP 138 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGL 179 S+VGTSSLRR QL + P L RS+RGN+ TRL KLD E+ AIILA AGL+R+G Sbjct: 139 EKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQEFSAIILATAGLQRMGW 198 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 +R+ L PE + AVGQGA+G+E R D +L+ L+ ET LR AERA LE Sbjct: 199 HNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLE 258 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-----------GAPQD------ 282 GGC VP+ + + DG+++L V + DGS I+ + G D Sbjct: 259 GGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIHVPAQHEDGPEDDPQLVGI 318 Query: 283 ------------AEQMGISLAEELLNNGAREILAEVYNGD 310 A+ +GISLA LL+ GA+ IL + Sbjct: 319 TARNIPRGPQLAAQNLGISLANLLLSKGAKNILDVARQLN 358 >UniRef50_B2A1G7 Porphobilinogen deaminase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=HEM3_NATTJ Length = 311 Score = 393 bits (1011), Expect = e-108, Method: Composition-based stats. Identities = 137/310 (44%), Positives = 195/310 (62%), Gaps = 5/310 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR+S LAL Q ++V ++L +P + +E+ + T+GD +L+ L+KVGGKGLF+K Sbjct: 2 KLRIGTRRSQLALDQTNWVVEQLKTHYPDIEIEIKKIETKGDQLLNVSLSKVGGKGLFLK 61 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E++ ALL+ D+AVHSMKD+P E + L + I +R DP DA +SNN ++D LP + Sbjct: 62 EIQNALLQGEIDLAVHSMKDIPTETTEDLEICAITKRVDPLDALISNNDITIDELPENAK 121 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESRI 183 +GTSSLRR QL R DL I +RGN+ TR++KL E DA++LA AGL R G+ I Sbjct: 122 IGTSSLRRGSQLKAYRNDLQIIPIRGNINTRMNKLQELPELDAVVLAKAGLVRSGMTDSI 181 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + PEI +P GQGA+G+E R D+ +E LA L+ E+ + AERA RL G C Sbjct: 182 SQNISPEIIVPCPGQGALGLEIRHDNENLKEKLAVLDDSESRKAIGAERAFLNRLGGSCH 241 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD----AEQMGISLAEELLNNGA 299 VP+G+YAE+I E+ L +V + DG +I+ + D +G LAEEL+ GA Sbjct: 242 VPVGAYAEIISNELHLTGVVASEDGQDVIKRSVQTHLSDNNKIPSTLGNDLAEELIELGA 301 Query: 300 REILAEVYNG 309 +IL+E+ G Sbjct: 302 NKILSELKEG 311 >UniRef50_Q30Y29 Porphobilinogen deaminase n=13 Tax=Bacteria RepID=HEM3_DESDG Length = 316 Score = 393 bits (1010), Expect = e-108, Method: Composition-based stats. Identities = 163/309 (52%), Positives = 206/309 (66%), Gaps = 2/309 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPG-LVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + IATR S LALWQA ++K+++M +P VEL+ + T+GD+ILD PLAKVGGKGLF Sbjct: 2 KKIVIATRGSKLALWQAEHIKERIMQQYPDSFEVELLVLKTKGDIILDVPLAKVGGKGLF 61 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 VKE+E ALL+ RADIAVHSMKDVP+E PQGL L I ERE P D+ +S YD LDALP G Sbjct: 62 VKEIEEALLDGRADIAVHSMKDVPMELPQGLTLGAIPEREVPTDSLLSARYDGLDALPQG 121 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 ++VGTSSLRRQ Q+ RPDL ++ LRGNV TR+ KL +GEYDAII+A +GLKRLG + Sbjct: 122 AVVGTSSLRRQSQILAMRPDLEVKWLRGNVQTRIRKLMDGEYDAIIMATSGLKRLGETAP 181 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 + L P + +PAVGQGA+G+E R D E+LA L+H + + V AER L+GGC Sbjct: 182 FHSELGPPLFMPAVGQGALGLEYRSDRQDLAEMLAFLDHRPSRICVEAERGFLFGLQGGC 241 Query: 243 QVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 QVPI YA + L LV DG+ +IR G DA G++LA ++ GA Sbjct: 242 QVPIAGYAVMTGDNSFELTGLVAELDGTAVIRRTAAGTEADARDTGLTLAAQVKAAGADA 301 Query: 302 ILAEVYNGD 310 IL VY Sbjct: 302 ILQRVYENG 310 >UniRef50_Q4L709 Porphobilinogen deaminase n=88 Tax=Bacillales RepID=HEM3_STAHJ Length = 310 Score = 391 bits (1005), Expect = e-107, Method: Composition-based stats. Identities = 139/310 (44%), Positives = 196/310 (63%), Gaps = 4/310 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L + +R+S LAL Q+ DKL A P L +E+ +VT+GD I++ L+KVGGKGLFV Sbjct: 2 RKLVVGSRRSKLALTQSQQFIDKLKAVDPTLEIEIKEIVTKGDRIVNKQLSKVGGKGLFV 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE++ L + D+A+HS+KDVP P+GL L I +RE P DA++S N+ L+ LP GS Sbjct: 62 KEIQQELFDKEIDMAIHSLKDVPSIIPEGLTLGCIPDREVPFDAYISKNHIPLNELPDGS 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 I+GTSSLRR Q+ + P+L I+ +RGN+ TRL KL+ +YDAIILA AGL+R+G I Sbjct: 122 IIGTSSLRRGAQILSKYPNLEIKWIRGNIDTRLKKLEIEDYDAIILAAAGLRRMGWSDDI 181 Query: 184 -RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 L +I LPA+GQGA+GIECR DD ELL+ +++ A VTAER + ++G C Sbjct: 182 VTTYLDKDILLPAIGQGALGIECRSDDVELLELLSKVHNQAVANCVTAERTFLSAMDGSC 241 Query: 243 QVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 QVPIG YA +GEI L+ PDG++ G ++ +G +++ L GA E Sbjct: 242 QVPIGGYATNKENGEIEFTGLIMTPDGTKRYEHTEVG--KNPVDLGEAVSRVLKEQGAYE 299 Query: 302 ILAEVYNGDA 311 I+ ++ A Sbjct: 300 IIKKLNEEQA 309 >UniRef50_B3QWI1 Porphobilinogen deaminase n=12 Tax=Chlorobiaceae RepID=HEM3_CHLT3 Length = 314 Score = 390 bits (1004), Expect = e-107, Method: Composition-based stats. Identities = 144/314 (45%), Positives = 195/314 (62%), Gaps = 4/314 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + L I TR SPLALWQA ++K +L +P L + L + T GD ILD PLAK+G KGL Sbjct: 1 MKKALIIGTRSSPLALWQAEFIKAELSKHYPSLDISLRHIKTTGDKILDAPLAKIGDKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F +E+E +L N D+AVHS+KD+P E P+GL + I ERED RD +S +L LP Sbjct: 61 FTREIEHVMLRNEIDLAVHSLKDLPTETPEGLVITAITEREDNRDVLISKGKYTLKTLPQ 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+IV TSSLRR+ QL RPDL + +RGN+ TR + + G+ +A++LA AG+ RL Sbjct: 121 GAIVATSSLRRRSQLLHLRPDLEVIDMRGNLNTRFKRFEEGDAEAMLLAFAGVHRLEFSE 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 I + + LPAVGQGA+GIE R+DD TRELL LNH ET L ER++ LEGG Sbjct: 181 HIAEIISFDDILPAVGQGALGIETRIDDEETRELLKVLNHAETELCTKCERSLLRTLEGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR----GAPQDAEQMGISLAEELLNN 297 CQ+PIG++A + +G VG+ DG + I+ ++AEQ+GI +A+ Sbjct: 241 CQIPIGAHARIENGTFHFATYVGSIDGKRAIKKSLSRENVTTVEEAEQIGIEVADAARAA 300 Query: 298 GAREILAEVYNGDA 311 GA EIL E+ +A Sbjct: 301 GANEILCEIRTDNA 314 >UniRef50_C9R7U0 Porphobilinogen deaminase n=1 Tax=Ammonifex degensii KC4 RepID=C9R7U0_AMMDK Length = 308 Score = 390 bits (1002), Expect = e-107, Method: Composition-based stats. Identities = 144/304 (47%), Positives = 186/304 (61%), Gaps = 3/304 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 LRI TR S LAL Q V L P E+V + T GD + + L ++GGKGL Sbjct: 4 SKRCLRIGTRGSDLALAQTEQVLQILRERWPHYTYEIVKIKTTGDKVRNLALPRIGGKGL 63 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F KELEVALLE + D+AVHS+KD+P E P+ L + + RE P D +S L+ LP Sbjct: 64 FTKELEVALLEEKIDLAVHSLKDLPTELPEELCVGAVLPREHPGDVLISLTGAGLEDLPE 123 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLK--RLGL 179 G+ +GTSSLRRQ QL RPDL LRGNV TRL KL+ GE +A++LA AGL+ RL L Sbjct: 124 GARIGTSSLRRQAQLKAARPDLNFVPLRGNVPTRLRKLEKGECEAVVLAWAGLRRLRLDL 183 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 R+ LP ++ LPAV QGA+G+E R +D R+++ L+ T L VTAERA L Sbjct: 184 TGRMT-LLPYQVCLPAVAQGAIGVEMRKEDRELRKMVEVLDDPTTRLEVTAERAFLRWLG 242 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GGC VPI + A + EI L LV P+G +I+RG+ G+ E++GI LAE LL GA Sbjct: 243 GGCHVPIAALARVAGAEILLEGLVADPEGKRIVRGQESGSTAYPEEVGIRLAERLLREGA 302 Query: 300 REIL 303 E+L Sbjct: 303 EELL 306 >UniRef50_B3E2H7 Porphobilinogen deaminase n=3 Tax=Proteobacteria RepID=HEM3_GEOLS Length = 312 Score = 389 bits (1001), Expect = e-107, Method: Composition-based stats. Identities = 161/310 (51%), Positives = 207/310 (66%), Gaps = 1/310 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M LRI TR S LALWQA++ K +L A +PG+ VELV + T GD ILD PLA+VGGKG Sbjct: 1 MAPKRLRIGTRASQLALWQANWTKSELEARYPGIQVELVKIKTMGDKILDVPLAQVGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E A+L D+AVHSMKDVP EFP+GLGLV +REDPRDAF+S + + L Sbjct: 61 LFVKEIEEAMLRGEIDLAVHSMKDVPTEFPEGLGLVVTTKREDPRDAFIS-DKVTFSELR 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GTS+LRRQ QL + RPDL + +RGNV TR+ KL DA+ILA AGL RLG Sbjct: 120 QGARIGTSALRRQAQLLKARPDLEMVIIRGNVETRIRKLKEDNLDAVILAAAGLNRLGFT 179 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 + L + S+PA+GQGA+G+ECRLDD+ T E LA LNH +TA V AERA+ R EG Sbjct: 180 DVVTELLDTDFSIPAIGQGALGLECRLDDNATIEALAFLNHADTAAAVAAERALLKRCEG 239 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GCQVPI ++ + + L + + DG Q +R G+ DA ++G LA+ LL G + Sbjct: 240 GCQVPIAAHGTVSGDTLTLVGFIASVDGKQTVRDRISGSTADAVKLGTELADRLLAAGGK 299 Query: 301 EILAEVYNGD 310 IL +VY + Sbjct: 300 AILEDVYQRE 309 >UniRef50_Q54P93 Porphobilinogen deaminase n=1 Tax=Dictyostelium discoideum RepID=HEM3_DICDI Length = 325 Score = 388 bits (997), Expect = e-106, Method: Composition-based stats. Identities = 132/317 (41%), Positives = 191/317 (60%), Gaps = 12/317 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 + I +R+S LA+ Q +V+D++ +PG++VE+ M T GD +LD L+K+G KGLF K Sbjct: 9 KVIIGSRKSQLAMLQTEWVRDRIQELNPGIIVEIKTMDTTGDKVLDVSLSKIGDKGLFTK 68 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN-----NYDSLDAL 119 ELE +L D+AVHS+KD+P + P GL L I +R + DAF++N L L Sbjct: 69 ELEDMMLNGTIDLAVHSLKDIPTKLPDGLKLGAITKRYNTSDAFIANAKKHGKNCKLSEL 128 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--DNGEYDAIILAVAGLKRL 177 P G+++G+SSLRR QL + P L + +RGN+ TR KL D+ YD +ILAVAGL+R+ Sbjct: 129 PQGAMIGSSSLRRVAQLKKAYPHLQFKDIRGNLNTRFKKLEDDSNGYDGMILAVAGLERM 188 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 L I +P ISL AVGQG++GIEC+ D + +L L H E+ AER+M Sbjct: 189 ELTDHISEIIPDSISLYAVGQGSLGIECKDGDDFIQSILNPLIHRESMYCCEAERSMLRD 248 Query: 238 LEGGCQVPIGSYAELI-----DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAE 292 LEGGC VPIG +L D + + A+V DGS+ I + G Q+G S+A+ Sbjct: 249 LEGGCHVPIGVVTKLHNQSQPDETLEINAIVLNLDGSKYIESKIIGPSIQYYQLGKSIAQ 308 Query: 293 ELLNNGAREILAEVYNG 309 +L+N G+++IL+E Sbjct: 309 DLINKGSKDILSEFIKK 325 >UniRef50_Q2LQU2 Porphobilinogen deaminase n=1 Tax=Syntrophus aciditrophicus SB RepID=HEM3_SYNAS Length = 306 Score = 385 bits (989), Expect = e-105, Method: Composition-based stats. Identities = 131/305 (42%), Positives = 186/305 (60%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 ++I TR S LAL Q + +L +P + +E+V + T GD+ D PLAK+GGKGLF+KE Sbjct: 1 MKIGTRGSALALTQTRQIAARLQGQYPEMHLEIVVIKTSGDIQKDVPLAKIGGKGLFIKE 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E ALL D+AVHSMKD+P E P+GL + + REDPRD +S D LPAG+ + Sbjct: 61 IEEALLAGTVDLAVHSMKDLPAELPEGLQIAAVPRREDPRDVLISGICREFDNLPAGARI 120 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT SLRR QL + RPDL I LRGN+ TR+ K+ D +++A AG++R+G ++ Sbjct: 121 GTGSLRRSVQLRDWRPDLEIVPLRGNLDTRIRKVAQAALDGVVVAAAGIRRMGWAEKVTQ 180 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 +P E LPAVGQG + +E R +D + LA L T VTAERA RL GGC +P Sbjct: 181 FIPTEKMLPAVGQGVLCLETREEDEDLKAGLAFLEDKRTRREVTAERAFLRRLGGGCTLP 240 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 + ++AE + +R +VG+ + +IR E G+ + A +G LAE LL+ G R +L Sbjct: 241 VAAFAEQRGDVLTIRGMVGSLNERTMIRQEIYGSVEQAVDLGTELAERLLDGGGRILLEH 300 Query: 306 VYNGD 310 + +G Sbjct: 301 LEDGQ 305 >UniRef50_A8PKX6 Porphobilinogen deaminase n=2 Tax=Gammaproteobacteria RepID=A8PKX6_9COXI Length = 311 Score = 384 bits (986), Expect = e-105, Method: Composition-based stats. Identities = 153/309 (49%), Positives = 194/309 (62%), Gaps = 3/309 (0%) Query: 1 MLDNV-LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGK 59 M LRIATR+SPLA WQA +K++L P L + L+P VT GD L + GGK Sbjct: 1 MSKKKFLRIATRKSPLAYWQATSIKNQLEKIFPFLKITLLPFVTEGDR-PSHSLNQWGGK 59 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 GLFVKELE ALL +ADIAVHS+KD+P+ +GL L IC+R DPRD +S + L Sbjct: 60 GLFVKELEAALLHGQADIAVHSLKDLPMTLEKGLVLGAICKRCDPRDVLISRSDRLFTQL 119 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P GS VGTSSLRRQ QL RPDL I LRGN+GTRL+KL GE+DAIILA AGL RL Sbjct: 120 PPGSYVGTSSLRRQSQLLALRPDLKIGVLRGNIGTRLNKLAAGEFDAIILAAAGLIRLKK 179 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 I + LPA GQGA+GIEC +D + ++AL H T V AERA++ L Sbjct: 180 TECISEYFEIDHFLPAPGQGALGIECHENDEESLTYISALIHPITHSCVLAERALSRELG 239 Query: 240 GGCQVPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GGCQVP+ +YA + I L+A VG+ DG+ I+ E++G +AE++G A++L G Sbjct: 240 GGCQVPLAAYAASLGQDFIRLQAFVGSSDGTTQIKVEKQGPRVEAEKIGFLAAQDLRALG 299 Query: 299 AREILAEVY 307 EIL + Sbjct: 300 VEEILNKFK 308 >UniRef50_A7NKU8 Porphobilinogen deaminase n=5 Tax=Bacteria RepID=HEM3_ROSCS Length = 303 Score = 382 bits (983), Expect = e-105, Method: Composition-based stats. Identities = 152/303 (50%), Positives = 195/303 (64%), Gaps = 1/303 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + N L I TR S LAL Q H ++D L A+HPGL V + + TRGD+ILD PL +G KGL Sbjct: 1 MRNSLTIGTRASKLALVQTHMIRDALQAAHPGLTVAVERITTRGDIILDRPLNAIGDKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FV E+E A+ R D+AVHS KD+P P + L R DPRDA V+ +L +LP Sbjct: 61 FVVEIEEAMRAGRVDLAVHSAKDLPSTLPPDMTLAVCPRRADPRDALVAQPGMTLASLPH 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ VGTSSLRR CQL RPDL + LRGNV TRL KL G+YDAI+LA AGLKRLGLE Sbjct: 121 GARVGTSSLRRACQLRALRPDLTLLDLRGNVDTRLRKLREGQYDAIVLAAAGLKRLGLEE 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 I L P++ +PAVGQG +G+E R D LLA L+ +TAERA R+ GG Sbjct: 181 VITELLEPDVLIPAVGQGIIGVEARAGDDEVLRLLAPLDDPAARAAITAERAFLARIGGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 C+VP+G+ A L E+ L ++GA DG +++RG R G+ D +G +LAEELL+ G + Sbjct: 241 CRVPVGALALLEGDELLLYGMIGALDG-RMVRGMRSGSASDPAGLGSALAEELLDAGGQA 299 Query: 302 ILA 304 +LA Sbjct: 300 LLA 302 >UniRef50_A3ETN3 Porphobilinogen deaminase n=2 Tax=Leptospirillum sp. Group II RepID=A3ETN3_9BACT Length = 314 Score = 382 bits (982), Expect = e-105, Method: Composition-based stats. Identities = 149/315 (47%), Positives = 191/315 (60%), Gaps = 5/315 (1%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 ML L+I +R S LALWQA +V + + G++ E+V + T GD+ILD L++VGGKG Sbjct: 1 MLPTPLKIGSRGSELALWQARHVASLIESVS-GVLPEIVVIKTTGDIILDRQLSEVGGKG 59 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E ALL D+AVHSMKDVP P GL L REDPRD F+S +Y + +LP Sbjct: 60 LFVKEIEEALLRKEIDLAVHSMKDVPAFLPPGLTLAATLTREDPRDVFLSPHYPDIKSLP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 + VGTSSLRR Q+ E R DL LRGNVGTR+ K++ G DAIILA AGL RLG Sbjct: 120 QKARVGTSSLRRLAQIREIRNDLEFIPLRGNVGTRIRKMEEGVVDAIILAGAGLLRLGHA 179 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 +R+R + P + LPA+GQGA+G+E R DD T L+ +L+ T L V AER + L G Sbjct: 180 NRVREWISPRVLLPAIGQGALGLEIRTDDETTGTLVRSLSDESTHLSVAAERGVLQSLNG 239 Query: 241 GCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERR---GAPQDAEQMGISLAEELLN 296 GCQVPI +YA + L V G++ I DA QMGI L LL+ Sbjct: 240 GCQVPIAAYAVWEKNRTLSLEGRVLDISGTRRIHARETRDIVTIDDAYQMGIDLGNRLLS 299 Query: 297 NGAREILAEVYNGDA 311 +GA EIL + + Sbjct: 300 DGAEEILNSILKKSS 314 >UniRef50_Q1J288 Porphobilinogen deaminase n=5 Tax=Deinococci RepID=HEM3_DEIGD Length = 309 Score = 382 bits (981), Expect = e-104, Method: Composition-based stats. Identities = 130/304 (42%), Positives = 181/304 (59%), Gaps = 3/304 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILD--TPLAKVGGKGL 61 + + TR S LAL Q +V +L P + + T+GD LA+ G KG Sbjct: 2 RTVTVGTRGSALALAQTRWVVARLKEEWPDTDFRIQTISTKGDRDRAALQSLAQKGDKGF 61 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALP 120 +VKE+E ALL R DIAVHS+KD+P E P+GL + +I +R D RD + + L+ LP Sbjct: 62 WVKEIEDALLAGRIDIAVHSLKDLPTEQPEGLEIASIPKRVDARDVLIGKDGMKRLEDLP 121 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 +G+ VGTSS+RR+ L RPDL I LRGN+ TRL+ L +YDAI+LA AGL R + Sbjct: 122 SGARVGTSSVRRKAFLRAYRPDLQILDLRGNIDTRLAALGTPDYDAIVLAAAGLIRTEMR 181 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 RI + P++ LPA GQGA+ +E R DD + E++ A++ H T RVTAER L Sbjct: 182 HRIDEFIDPDLLLPAPGQGALALETRADDDLSIEVVYAIHDHATDDRVTAEREFLAGLGA 241 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 GC P+G++A L DG + L VGA DGSQ+IR G P + +G LA ++L GA+ Sbjct: 242 GCMAPVGAHATLKDGVLTLEGWVGALDGSQVIRATTSGDPAECADLGAELAADMLGQGAQ 301 Query: 301 EILA 304 +++ Sbjct: 302 QLIE 305 >UniRef50_Q180R9 Porphobilinogen deaminase n=11 Tax=Bacteria RepID=HEM3_CLOD6 Length = 301 Score = 380 bits (976), Expect = e-104, Method: Composition-based stats. Identities = 110/293 (37%), Positives = 171/293 (58%), Gaps = 1/293 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 + + TR S LAL Q +V ++L +P + E+ + T+GD+I + L K+G KGLFVKE Sbjct: 3 IVVGTRGSNLALIQTEWVINELKKKYPEISFEIKIIKTKGDLIQNVSLDKIGDKGLFVKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS-LDALPAGSI 124 +E LL+ + DIAVHSMKD+P GL +REDPRD + LD LP G++ Sbjct: 63 IEQQLLDGKIDIAVHSMKDMPSYLANGLKFAHTPKREDPRDVLILREGYKNLDDLPHGAV 122 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GT S RR+ QL ++RPDL I +RGNV TR+ K+ + I+LA +G+ R L+ +I Sbjct: 123 IGTGSKRRKFQLLKQRPDLNIVQVRGNVETRIRKIKDENMHGIVLAASGIIRANLQDKIS 182 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 + LP ++ +PA QGA+ IE R +DS ++ +L T +++ AER + G C + Sbjct: 183 SYLPVDVVIPAPAQGALAIEIRSNDSAIEGIVNSLKDENTEIQILAERGFLDGVNGSCHI 242 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 P+ +Y E+I +I L L G +G +++ G ++G+ LA+ +L Sbjct: 243 PMAAYCEIIQDKIHLTGLYGDSEGKKVVIKSIDGDISSPRELGLKLAKLVLKE 295 >UniRef50_A6WXJ2 Porphobilinogen deaminase n=56 Tax=cellular organisms RepID=HEM3_OCHA4 Length = 314 Score = 380 bits (976), Expect = e-104, Method: Composition-based stats. Identities = 132/306 (43%), Positives = 174/306 (56%), Gaps = 2/306 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGG 58 + + L+I TR S LAL QA+ + +LM +H P +E++PM T GD I D L+++GG Sbjct: 6 LKNGTLKIGTRGSKLALAQAYETRRRLMEAHGLPEEAIEIIPMSTAGDRIQDRALSEIGG 65 Query: 59 KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118 KGLF +E+E AL + R D+AVHS KD+P P GL L EREDPRDAF+ L Sbjct: 66 KGLFTEEIEQALTDGRIDLAVHSTKDMPTVLPDGLHLSVFLEREDPRDAFIGRTASRLLD 125 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 LP G+ VG+SSLRRQ + RPD+ + RGNV TRL KL+ GE D LA AGL+RLG Sbjct: 126 LPQGATVGSSSLRRQALIRRLRPDIQVVIFRGNVDTRLRKLEAGEVDGTFLACAGLRRLG 185 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 L I PE PA GQGA+GIE R+ D+R LLA L H ET + + ERA L Sbjct: 186 LGDVITDLADPESFPPAPGQGAIGIETRIGDTRIDTLLAPLAHRETGIALACERAFLAAL 245 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 +G C+ PI A + + ++ PDGS+ + G +A +G AE L Sbjct: 246 DGSCRTPIAGLATVNGDTVSFHGMILKPDGSEAHEIKTEGPASNAAAIGTEAAEHLRAKA 305 Query: 299 AREILA 304 + Sbjct: 306 GPQFFE 311 >UniRef50_B6FXV9 Putative uncharacterized protein n=1 Tax=Clostridium hiranonis DSM 13275 RepID=B6FXV9_9CLOT Length = 299 Score = 379 bits (975), Expect = e-104, Method: Composition-based stats. Identities = 113/298 (37%), Positives = 176/298 (59%), Gaps = 1/298 (0%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +R+ TR S LAL Q ++ D+L P + E+ + T+GD IL L K+G KGLFVK Sbjct: 2 KIRVGTRGSNLALIQTNWAIDRLKEKFPEVEFEVKIIKTKGDKILHLSLDKIGDKGLFVK 61 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALPAGS 123 E+E LLE D+AVHSMKD+P E +GL + +REDPRD + +S D LP G+ Sbjct: 62 EIESQLLEGEIDLAVHSMKDMPAEVVEGLKFAAVPKREDPRDVIILREGLNSFDELPIGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +GT S RR+ QL +RPDL I +RGN+ TR+SK+++ D I+LA +G+ R LE +I Sbjct: 122 TIGTGSKRRKYQLLRKRPDLNIVPIRGNIETRISKIESENLDGIVLAASGVIRADLEEKI 181 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 LP ++ +PA QGA+ +E R +D +++ A+ + ++ AER+ ++G C Sbjct: 182 TEFLPVDLMIPAPAQGALALEIRENDEELEKMIDAIKDEISQIQTDAERSYLAGIDGSCH 241 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 +P+G+Y E+ ++ L + G DG +I G + +++G +LA+ +L E Sbjct: 242 IPMGAYCEVDGEKLTLTGIFGDEDGEKITVASLEGDRDNPKELGSNLAKLVLKKHREE 299 >UniRef50_B2S842 Porphobilinogen deaminase n=38 Tax=Rhizobiales RepID=HEM3_BRUA1 Length = 314 Score = 377 bits (970), Expect = e-103, Method: Composition-based stats. Identities = 134/305 (43%), Positives = 170/305 (55%), Gaps = 2/305 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGK 59 + L+I TR S LAL QA+ + L +H P +E++PM T GD I D PL++VGGK Sbjct: 7 KNGTLKIGTRGSKLALAQAYLTRRLLQEAHGLPEDAIEILPMSTAGDRIQDRPLSEVGGK 66 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 GLF +E+E AL + R DIAVHS KD+P P+GL L EREDPRDAF+ + L Sbjct: 67 GLFTEEIEQALKDGRIDIAVHSTKDMPTALPEGLHLSVFLEREDPRDAFIGRSARRFMDL 126 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P G+ VG+SSLRRQ + RPD+ + RGNV TRL KLD GE D LA AGL+RLGL Sbjct: 127 PQGATVGSSSLRRQALIRRLRPDIEVVMYRGNVDTRLRKLDAGEVDGTFLACAGLRRLGL 186 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 I L P + PA GQGA+GIE R+ D R LLA L H ET + + ERA L+ Sbjct: 187 ADVITDVLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERAFLGALD 246 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 G C+ PI A + + R ++ PDG Q G DA +G A + Sbjct: 247 GSCRTPIAGLATVEGDRLSFRGMILTPDGRQAHEVTAEGVVSDAAALGTDAANRVRAMAG 306 Query: 300 REILA 304 Sbjct: 307 PHFFD 311 >UniRef50_A7GYU4 Porphobilinogen deaminase n=34 Tax=Campylobacterales RepID=HEM3_CAMC5 Length = 311 Score = 377 bits (970), Expect = e-103, Method: Composition-based stats. Identities = 160/307 (52%), Positives = 200/307 (65%), Gaps = 3/307 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +L+IATR+S LALWQ+ ++K +LMA H GL VELV M T+GDVILDTPLAK+GGKGLF Sbjct: 2 KILKIATRKSALALWQSEHIKARLMAQHAGLQVELVGMKTKGDVILDTPLAKIGGKGLFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE ++L + IAVHS+KDVPV F GL L IC RED RDA +S Y D LP + Sbjct: 62 KELEDSMLSGQTHIAVHSLKDVPVAFLDGLVLAAICSREDVRDAMISQRYVKFDDLPQSA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGT+SLRR+ QL RPDL I SLRGNV TRL KL GE+DAIILA+AG+ RL L + Sbjct: 122 KVGTTSLRRKMQLLRMRPDLNIISLRGNVQTRLRKLKEGEFDAIILAMAGINRLNLADEV 181 Query: 184 RAALPPEI--SLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 P +I PA+GQGA+G+E +DD++ E + LN + + ER T LEGG Sbjct: 182 AHIYPFDIAQMTPAMGQGALGVEA-VDDAQILEKIKFLNDERSVIETRVERDFVTLLEGG 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 CQVPIG A L EI + A+VG PDGS++I + E +G LA E + GA+E Sbjct: 241 CQVPIGINARLASEEIEINAIVGLPDGSEVITENLTAKKSEFESVGKELAREFIARGAKE 300 Query: 302 ILAEVYN 308 +L Sbjct: 301 LLKRAEE 307 >UniRef50_O94048 Porphobilinogen deaminase n=53 Tax=Saccharomyceta RepID=HEM3_CANAL Length = 340 Score = 375 bits (965), Expect = e-103, Method: Composition-based stats. Identities = 129/319 (40%), Positives = 185/319 (57%), Gaps = 17/319 (5%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 N ++I R+S LA+ Q+ VK + + P L ++ + T GD + PL GGK L+ Sbjct: 11 SNHVQIGGRKSKLAVVQSEIVKKVIEDTFPNLSCSILALSTLGDKVQTQPLYTFGGKSLW 70 Query: 63 VKELEVALLEN-----RADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---D 114 KELE+ LL++ + D+ VHS+KD+P P+ L I +REDPRDA V Sbjct: 71 TKELEILLLDSVDEFPKLDLIVHSLKDMPTNLPEEFELGCIFQREDPRDAIVMKQGSSYK 130 Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVA 172 SL LPAG+IVGTSS+RR QL + P L S+RGN+ TRL+KLD N EY +ILA A Sbjct: 131 SLKDLPAGAIVGTSSIRRSSQLIKNYPHLRFESVRGNIQTRLNKLDQPNNEYCCLILASA 190 Query: 173 GLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232 GL RLGL RI + L + AVGQGA+GIE R D + +L + + AER Sbjct: 191 GLIRLGLGHRITSYL--DDMYYAVGQGALGIEIRKGDDNIKSILKKIEDPIATICCLAER 248 Query: 233 AMNTRLEGGCQVPIGSYAELIDGE--IWLRALVGAPDGSQIIRGER---RGAPQDAEQMG 287 ++ LEGGC VP+G +++ + + + L+ ++ +PDG+ I E +D EQ+G Sbjct: 249 SLMRYLEGGCSVPLGVHSDYNESKQELTLKGIIVSPDGTVSIEDEVIKRITCDEDCEQVG 308 Query: 288 ISLAEELLNNGAREILAEV 306 I L ++L GA+EIL ++ Sbjct: 309 IELGDKLKAKGAKEILDKI 327 >UniRef50_A6Q7Y4 Porphobilinogen deaminase n=7 Tax=Epsilonproteobacteria RepID=HEM3_SULNB Length = 323 Score = 375 bits (963), Expect = e-102, Method: Composition-based stats. Identities = 137/319 (42%), Positives = 191/319 (59%), Gaps = 10/319 (3%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L IATR S LALWQA+++K+++ + P + VEL + ++GD ILD PLA VGGKG F Sbjct: 2 EKLVIATRASNLALWQAYHIKERIETAFPEVRVELNEITSKGDKILDKPLALVGGKGHFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE ++ A +AVHS+KDVP P+GL L I ER+D D F+S+ Y SL LP G+ Sbjct: 62 KELEDEMIAGNAHLAVHSLKDVPTYIPEGLELCAITERQDQSDVFLSHTYKSLSELPEGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +VGT+SLRR+ QL E+RPDL ++ LRGNV TRL KL G+YDAIILA GL RL L I Sbjct: 122 VVGTTSLRRRMQLLEKRPDLKVKDLRGNVNTRLRKLKEGQYDAIILAYIGLYRLDLLKDI 181 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + +P +GQ A+GIE ++ R RE+ LNH T + ER + + GC Sbjct: 182 PYVEKLDFFIPPMGQAALGIEIVANNDRIREIAMTLNHEPTFICTKVERDFISVIGAGCS 241 Query: 244 VPIGSYAELIDGE------IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 P+ A + E I +RA++G PDG+ I+ +A+ +G LA+ ++ Sbjct: 242 APVAVNATMDKKEDDKVPTISVRAMIGYPDGTHILHKSLTVPLNEADILGDELAQAMIEE 301 Query: 298 GAREILAE----VYNGDAP 312 GA +IL + + + P Sbjct: 302 GALDILEQAEIIAFKDEMP 320 >UniRef50_D0LUE1 Porphobilinogen deaminase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LUE1_HALO1 Length = 320 Score = 373 bits (959), Expect = e-102, Method: Composition-based stats. Identities = 156/315 (49%), Positives = 196/315 (62%), Gaps = 11/315 (3%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M + + I+TR S LALWQAH+V+D++ P VELV + T+GD ILD PL+K+GGK Sbjct: 1 MSERTIHISTRGSQLALWQAHHVRDEIRRVRPAWQVELVIIKTQGDKILDVPLSKIGGKA 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LFVKE+E ALL+ RAD+AVHSMKDVP E GL + REDP DA + + LD L Sbjct: 61 LFVKEIEQALLDGRADVAVHSMKDVPAELAPGLFMAATSRREDPYDALCTRDGRGLDELA 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GTSSLRRQCQ+ RRPDL I LRGNV TRL KLD+G +DA+ILA AGLKRLG Sbjct: 121 EGATLGTSSLRRQCQILARRPDLRIEMLRGNVPTRLGKLDDGSFDAVILAAAGLKRLGHG 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDD-----SRTRELLAALNHHETALRVTAERAMN 235 RI L + +PAVGQG +GIE R D L AL+ RV AERAM Sbjct: 181 ERISQRLDGGVCVPAVGQGVLGIETRQGDAPADRELVEALREALHDPAEERRVVAERAMM 240 Query: 236 TRLEGGCQVPIGSYAELIDG------EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGIS 289 L G CQ P+ ++A + + L G PDGS+I+R + G +DA+ +G S Sbjct: 241 AALGGSCQTPLAAHASYRGDSDPVAGTLVIEGLCGRPDGSEILRAQVEGRAEDAQALGSS 300 Query: 290 LAEELLNNGAREILA 304 LAEEL GA+ I+ Sbjct: 301 LAEELRGQGAQAIID 315 >UniRef50_Q43316 Porphobilinogen deaminase, chloroplastic n=61 Tax=cellular organisms RepID=HEM3_ARATH Length = 382 Score = 372 bits (957), Expect = e-102, Method: Composition-based stats. Identities = 137/303 (45%), Positives = 185/303 (61%), Gaps = 8/303 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGL----VVELVPMVTRGDVILDTPLAKVGGKG 60 ++RI TR SPLAL QA+ ++KL HP L + + + T GD IL PLA +GGKG Sbjct: 74 IIRIGTRGSPLALAQAYETREKLKKKHPELVEDGAIHIEIIKTTGDKILSQPLADIGGKG 133 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF KE++ AL+ DIAVHSMKDVP P+ L RED RDAF+ +L LP Sbjct: 134 LFTKEIDEALINGHIDIAVHSMKDVPTYLPEKTILPCNLPREDVRDAFICLTAATLAELP 193 Query: 121 AGSIVGTSSLRRQCQLAERRPDLII-RSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 AGS+VGT+SLRR+ Q+ + P L + + RGNV TRLSKL G+ A +LA+AGLKRL + Sbjct: 194 AGSVVGTASLRRKSQILHKYPALHVEENFRGNVQTRLSKLQGGKVQATLLALAGLKRLSM 253 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 + + L + LPAV QGA+GI CR DD + LA+LNH ET L ++ ERA L+ Sbjct: 254 TENVASILSLDEMLPAVAQGAIGIACRTDDDKMATYLASLNHEETRLAISCERAFLETLD 313 Query: 240 GGCQVPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGA--PQDAEQMGISLAEELLN 296 G C+ PI YA + +G R LV +PDG++++ R+G +D +MG +ELL+ Sbjct: 314 GSCRTPIAGYASKDEEGNCIFRGLVASPDGTKVLETSRKGPYVYEDMVKMGKDAGQELLS 373 Query: 297 NGA 299 Sbjct: 374 RAG 376 >UniRef50_D2R3S6 Porphobilinogen deaminase n=2 Tax=Planctomycetaceae RepID=D2R3S6_9PLAN Length = 311 Score = 372 bits (957), Expect = e-102, Method: Composition-based stats. Identities = 144/303 (47%), Positives = 192/303 (63%), Gaps = 2/303 (0%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LR+ TR SPLA WQA +V+D+L+A+ G+ VE++ + T GD PL ++GG+GLF K Sbjct: 6 KLRLGTRASPLARWQADWVRDQLIAA--GIDVEMILITTEGDQQTSQPLGQIGGQGLFTK 63 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E++ LL D+AVHS+KD+P GL L + ERED D + SL LP+G+ Sbjct: 64 EIQRRLLAGDIDLAVHSLKDLPTLPIDGLSLAAVPEREDTADILIGPAGTSLATLPSGAK 123 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GT SLRR+ QL R DL I +RGNV TRL KLD G+Y AIILA AGLKRL L+ R+ Sbjct: 124 IGTGSLRRKAQLLHARADLEILDIRGNVDTRLRKLDEGQYHAIILAAAGLKRLKLDDRMT 183 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L + LPAVGQGA+GIE R DD TR+LLA L+H T V AER++ L GC Sbjct: 184 ERLEAPLMLPAVGQGALGIESRSDDPTTRKLLAPLSHAPTLQAVIAERSLLAALRAGCLA 243 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 P+G++A+++DG++ L A+V + DG + AP DA Q+G +AE L GA E+LA Sbjct: 244 PVGAHAQVVDGQLTLAAVVLSIDGQSRLFASLTSAPADAAQLGEEVAELLRQQGATELLA 303 Query: 305 EVY 307 Sbjct: 304 SSR 306 >UniRef50_P28789 Porphobilinogen deaminase n=18 Tax=Saccharomycetales RepID=HEM3_YEAST Length = 327 Score = 371 bits (954), Expect = e-101, Method: Composition-based stats. Identities = 123/322 (38%), Positives = 177/322 (54%), Gaps = 15/322 (4%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M L I R+S LA+ Q+++V + +P ++ + T GD I PL GGK Sbjct: 1 MGPETLHIGGRKSKLAVIQSNHVLKLIEEKYPDYDCKVFTLQTLGDQIQFKPLYSFGGKA 60 Query: 61 LFVKELEVALL----ENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NY 113 L+ KELE L + D+ VHS+KD+P P+G L I +R DP D V Y Sbjct: 61 LWTKELEDHLYHDDPSKKLDLIVHSLKDMPTLLPEGFELGGITKRVDPTDCLVMPFYSAY 120 Query: 114 DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAV 171 SLD LP G IVGTSS+RR QL + P L S+RGN+ TRL KLD+ + Y IILA Sbjct: 121 KSLDDLPDGGIVGTSSVRRSAQLKRKYPHLKFESVRGNIQTRLQKLDDPKSPYQCIILAS 180 Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231 AGL R+GLE+RI + AVGQGA+GIE R D++ ++L + + +E Sbjct: 181 AGLMRMGLENRITQRFHSDTMYHAVGQGALGIEIRKGDTKMMKILDEICDLNATICCLSE 240 Query: 232 RAMNTRLEGGCQVPIGSYAELIDG--EIWLRALVGAPDGSQIIRGE----RRGAPQDAEQ 285 RA+ LEGGC VPIG ++ + ++ L+A+V +G++ + E +D+ Sbjct: 241 RALMRTLEGGCSVPIGVESKYNEETKKLLLKAIVVDVEGTEAVEDEIEMLIENVKEDSMA 300 Query: 286 MGISLAEELLNNGAREILAEVY 307 G LAE ++ +GA++IL E+ Sbjct: 301 CGKILAERMIADGAKKILDEIN 322 >UniRef50_A5VM67 Porphobilinogen deaminase n=9 Tax=Lactobacillus RepID=HEM3_LACRD Length = 305 Score = 370 bits (952), Expect = e-101, Method: Composition-based stats. Identities = 118/298 (39%), Positives = 167/298 (56%), Gaps = 4/298 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + N + + +R+S LA+ Q V L P + E+ ++T GD LAK+GGKG+ Sbjct: 1 MTNKVIVGSRKSKLAMAQTELVIASLEKIFPDIKFEIKNVITEGDRNRHVSLAKIGGKGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALP 120 FVKE+E L + D AVHS+KDV P+ L L +R P D VS SL+ LP Sbjct: 61 FVKEIEDELKDGTIDFAVHSLKDVMPILPEELVLGAFPKRVSPYDCLVSRKNLSSLNDLP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GT+SLRRQ QL RPDL I +RGN+ TRL K+D D IILA AGL RL ++ Sbjct: 121 KGARIGTNSLRRQGQLLSIRPDLKIIPIRGNIDTRLRKIDTEALDGIILAEAGLTRLNID 180 Query: 181 SRIRAALPPE-ISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 L + +PAVGQG + IECR +D+R R++L +N E+A V ER L Sbjct: 181 LSSYHVLDLQNYIMPAVGQGCLAIECRKNDTRIRKMLDQINDEESAYCVQVEREFMRELG 240 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 G C PIG +A +G+I L+ +P+G +I+ + P + +G +A++LL Sbjct: 241 GSCNFPIGGHAYAKNGQILFDGLIASPNGEHVIKETKI--PANNSGVGKKVADQLLAK 296 >UniRef50_Q8RFP5 Porphobilinogen deaminase n=16 Tax=Fusobacteriaceae RepID=HEM3_FUSNN Length = 298 Score = 370 bits (950), Expect = e-101, Method: Composition-based stats. Identities = 119/298 (39%), Positives = 166/298 (55%), Gaps = 5/298 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPL--AKVGGK 59 + + I +R S LAL QA+ VKD+L ++P L E+ +VT GD L + + + K Sbjct: 1 MKKNIIIGSRGSILALAQANLVKDRLQGNYPNLSFEIKEIVTSGDKDLKSNWENSDISLK 60 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 F KE+E LL+ DIAVHSMKD+P + L I +REDPRD VS N L L Sbjct: 61 SFFTKEIEQELLDGEIDIAVHSMKDMPAVSAKSLICGAIPDREDPRDVLVSKNGL-LVTL 119 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P G+ VGTSSLRR L RPD I+ LRGN+ TRL KL+ +YDAI+LA AGLKR GL Sbjct: 120 PQGAKVGTSSLRRAMNLKTVRPDFEIKHLRGNIHTRLKKLETEDYDAIVLAAAGLKRTGL 179 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 +I L E+ PA QG + I+CR +D +E+L ++++ A V ER + + Sbjct: 180 ADKITEYLNGEVFPPAPAQGVLYIQCRENDEEIKEILKSIHNEAIAKIVEIEREFSKIFD 239 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 GGC P+G Y+++ +I A+ D + IR +++ AEE+ N Sbjct: 240 GGCHTPMGCYSQVNGDKIKFTAVY--LDEGKQIRAVVEDDLAKGKEIAYMAAEEIKNK 295 >UniRef50_UPI0001926E0E PREDICTED: similar to hydroxymethylbilane synthase, partial n=1 Tax=Hydra magnipapillata RepID=UPI0001926E0E Length = 418 Score = 369 bits (948), Expect = e-101, Method: Composition-based stats. Identities = 123/342 (35%), Positives = 167/342 (48%), Gaps = 35/342 (10%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + + +R+S LA+ Q + L + + M T GD IL L K+G K LF Sbjct: 28 KTSVVVGSRKSQLAVIQTKSIVAALCQKEKDVECIIETMDTLGDKILHIALPKIGEKSLF 87 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDAL 119 K+LE+AL E R D VHS+KD+P PQG+ + TI +R+DPRD + + N L L Sbjct: 88 TKDLELALSEKRVDFLVHSLKDLPTTLPQGMAISTIYKRDDPRDCIIFHPKHNGKKLADL 147 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-YDAIILAVAGLKRLG 178 P SI+GTSSLRR QL + L +S+RGN+ TRL KL+ YDAI+LA AG+ R+G Sbjct: 148 PENSIIGTSSLRRVAQLKRKYNKLTFQSVRGNLNTRLQKLEEESLYDAIVLAKAGVDRMG 207 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 +I L + L A+GQGA+ +E R DD T +LA L ET L AER L Sbjct: 208 WTEKIGQILSEDECLYAIGQGAITVEVRNDDKYTISILAQLTDMETLLACVAERCFMRTL 267 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ----------------- 281 GGC PI +++ LR +V DGS+ + Q Sbjct: 268 NGGCSTPIACHSQFSGNNYSLRGIVLNADGSRFLDSTVSTTLQVNILTDQNEPPSYTVSK 327 Query: 282 --------------DAEQMGISLAEELLNNGAREILAEVYNG 309 AE+ G LA L GA ++L EV + Sbjct: 328 SGVVINSLYINEFIKAEKCGEELAYCLKKLGADDVLKEVRSK 369 >UniRef50_C8WXM9 Porphobilinogen deaminase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WXM9_ALIAD Length = 305 Score = 369 bits (947), Expect = e-101, Method: Composition-based stats. Identities = 151/301 (50%), Positives = 196/301 (65%), Gaps = 2/301 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 LR+ATR+S LAL Q ++V D L G+ ELVP+ TRGD I+D L++VGGKGLFV Sbjct: 2 RTLRVATRRSALALTQTNHVVDLLKQVAHGVEFELVPIRTRGDEIVDRALSEVGGKGLFV 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 ++E AL +AD+AVHS+KDVP E GL + + REDPRDA +S L LP G+ Sbjct: 62 ADIEDALATGQADLAVHSLKDVPFELRDGLTIGAVPPREDPRDALISRTGQGLFDLPPGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGTSSLRRQ L RPDL + +LRGNV TRL +L+ G++DAI+LA +GL RLGL RI Sbjct: 122 RVGTSSLRRQAALRRLRPDLCVETLRGNVDTRLRRLEEGQFDAIVLAASGLHRLGLAERI 181 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 LP + +PAVGQGA+ IECR +D LAA+ + V AERA +RLEG CQ Sbjct: 182 TEYLPVDRFVPAVGQGALAIECRAEDDEVMRHLAAIADPDATRAVEAERAFLSRLEGSCQ 241 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 VPIG+YAE + E+ L A V P G ++ ER G +A +G+++AEE+L GA + L Sbjct: 242 VPIGAYAEPVGHELRLIAFVADPSGIHHLQLERTG--DEARALGVAMAEEMLRQGAEDWL 299 Query: 304 A 304 Sbjct: 300 K 300 >UniRef50_B3T8H9 Putative Porphobilinogen deaminase, dipyromethane cofactor binding domain protein n=1 Tax=uncultured marine microorganism HF4000_APKG5H11 RepID=B3T8H9_9ZZZZ Length = 322 Score = 369 bits (947), Expect = e-100, Method: Composition-based stats. Identities = 122/306 (39%), Positives = 171/306 (55%), Gaps = 1/306 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +++ +R S LAL Q H V ++L A+ P L E+ + TRGDV + LA +G G+FVKE Sbjct: 18 IKVGSRGSTLALIQDHVVINRLKANSPALEFEVDTVRTRGDVDQTSRLAGMG-LGIFVKE 76 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE LL+ + DIAVHS+KD+P + GL L + REDPRD V+ LD LP G+ + Sbjct: 77 LEQELLDGKLDIAVHSLKDMPTQLADGLVLGAVLSREDPRDVLVNRYGCPLDGLPKGAKI 136 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS RR QL + P + + S+RGNV TRL K E D ILA AG+ RLGL+ +I Sbjct: 137 GTSSPRRAAQLKQYAPQVEVVSIRGNVETRLRKAQGEEADGAILAAAGMIRLGLQDQIAE 196 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L +P GQG + +E R DD R ELL+A++ +T TAER RL GGC +P Sbjct: 197 YLSATQFVPPPGQGILAVEARADDFRMLELLSAIDDADTRYEATAERGFLARLGGGCSIP 256 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 +G+YA I + + DG + + +G +D Q+ L+ G +++A Sbjct: 257 VGAYARCNGDNIVMTIYMSTADGEKKFSAKIQGLKRDPLQLANDAYLALVERGGADLVAA 316 Query: 306 VYNGDA 311 A Sbjct: 317 ARANQA 322 >UniRef50_A9A1A1 Probable porphobilinogen deaminase n=3 Tax=Thaumarchaeota RepID=HEM3_NITMS Length = 311 Score = 369 bits (947), Expect = e-100, Method: Composition-based stats. Identities = 107/298 (35%), Positives = 171/298 (57%), Gaps = 2/298 (0%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 + R S L++ Q + V +L +HP E+ + T+GD PL + KG+F K Sbjct: 2 KYIVGARGSQLSVAQTNLVIAELKKAHPDTEYEIKTITTKGDTD-SRPLFTIDQKGIFEK 60 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E++ A+ + D AVHS+KDVP E L L I +RE D F+S + +LD++ GS+ Sbjct: 61 EIDRAVAQKEVDFAVHSLKDVPSELDDNLVLACIPKRETVNDVFISPDGSTLDSIKPGSV 120 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSSLRR Q++ +RPD+ ++ +RGN+ TR+ K YDAI+LA AG+ RLG++ + Sbjct: 121 IGTSSLRRAVQVSRKRPDVTVKPIRGNIETRIKKASGENYDAIVLAKAGISRLGVDVKYT 180 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L + P+ GQGA+ I R DDS+T E+L + ++ L + AERA++ ++ GC+ Sbjct: 181 E-LSTDDFSPSPGQGAIAIVARADDSKTIEMLKKIEDPDSRLEIEAERALSDFVDSGCRF 239 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 P+G+YA+ E+ L + DG Q + + G + + +G S EEL G ++ Sbjct: 240 PVGAYAKSNGSEMTLTVTAFSVDGKQFLHVSKTGDKNNPKSLGQSAGEELREKGVNDL 297 >UniRef50_A8LIJ6 Porphobilinogen deaminase n=11 Tax=Alphaproteobacteria RepID=A8LIJ6_DINSH Length = 347 Score = 368 bits (945), Expect = e-100, Method: Composition-based stats. Identities = 144/304 (47%), Positives = 191/304 (62%), Gaps = 2/304 (0%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKG 60 D+ L+I TR S LAL QAH + +L A+ P E+V + T GD I D L+++GGKG Sbjct: 38 DSPLKIGTRGSLLALAQAHETRARLSAAFDLPEEAFEIVVIKTTGDRIQDRSLSEIGGKG 97 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF +E+E A+L+ DIAVHSMKD+PV+ P GL L T RED RDAFV+ + +L LP Sbjct: 98 LFTREIEDAMLDGSIDIAVHSMKDMPVDTPAGLALDTYLPREDVRDAFVTLDGGTLADLP 157 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G++VG+SSLRR+ QLA RRPDL + RGNV TR+ KL +G A LA+AGL RLG++ Sbjct: 158 EGAVVGSSSLRRRAQLAHRRPDLQLVEFRGNVQTRMKKLGDGVAHATFLAMAGLNRLGMD 217 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R+A+ PE LPAV QG +GIE R DD R E+LAA++ + R+ ERA + L+G Sbjct: 218 EVPRSAIAPEDMLPAVAQGCIGIERRADDPRAAEMLAAIHDGPSGHRLACERAYLSALDG 277 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300 CQ PI AEL G I LRA + PDGS+++ +DA +MG +AE L Sbjct: 278 SCQTPIAGLAELDGGSIHLRAEILRPDGSEVLSDSETAPVEDAAKMGREVAERLRARAPD 337 Query: 301 EILA 304 + Sbjct: 338 GFFS 341 >UniRef50_UPI00017922DC PREDICTED: similar to porphobilinogen deaminase n=1 Tax=Acyrthosiphon pisum RepID=UPI00017922DC Length = 377 Score = 368 bits (945), Expect = e-100, Method: Composition-based stats. Identities = 130/364 (35%), Positives = 186/364 (51%), Gaps = 59/364 (16%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +R+ +R+S LAL Q +V +L HP + E+V M T GD +LD PL K+G K LF Sbjct: 7 KTIRVGSRKSELALIQTKFVISQLKELHPEIEFEIVSMTTMGDRVLDKPLPKIGEKSLFT 66 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS---LDALP 120 K+LEVALL D VHS+KD+P G + I +R+DPRDA V + LD+LP Sbjct: 67 KDLEVALLSGTVDFIVHSLKDLPTVMEIGTTIGAILKRDDPRDALVLRDDCKEYQLDSLP 126 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE---------YDAIILAV 171 + S +GTSSLRR QL + P+L + +RGN+ TRL KLD+ + Y IILA+ Sbjct: 127 SKSFIGTSSLRRTAQLKRKFPNLQVSDVRGNLNTRLKKLDSSQSTGDNTNTNYSGIILAL 186 Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231 AG++R+G E R+ + ++ L AVGQGA+ +ECRL D E+L L+H+ET L+V AE Sbjct: 187 AGIQRMGWEKRVSQIIDSDVMLYAVGQGALAVECRLGDDYILEMLEPLHHYETVLQVVAE 246 Query: 232 RAMNTRLEGGCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQD------- 282 R TRL GGC P+G + + + L V + DG++ ++ D Sbjct: 247 RGFLTRLGGGCSAPVGIRSTVCLTKNAMSLDGAVWSLDGAEELQYSSSAELADKKVIQSH 306 Query: 283 --------------------------------------AEQMGISLAEELLNNGAREILA 304 A ++G LAE L++ GA +I+ Sbjct: 307 IDQYRGEDGEPPKKCPYKQPRQFVGVTPGKISYLDLDTALKLGTELAENLISKGALDIMN 366 Query: 305 EVYN 308 Sbjct: 367 AAKE 370 >UniRef50_C1CYD9 Porphobilinogen deaminase n=3 Tax=Deinococci RepID=HEM3_DEIDV Length = 311 Score = 367 bits (944), Expect = e-100, Method: Composition-based stats. Identities = 126/310 (40%), Positives = 176/310 (56%), Gaps = 5/310 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDT--PLAKVGGKGL 61 + + TR S LAL Q +V +L P + + T+GD ++ +A+ G KG Sbjct: 2 RTVTVGTRGSTLALAQTRWVVARLKEEWPDTDFRIQTISTKGDRNRESLEAMAQKGDKGF 61 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALP 120 +VKE+E ALL+ R DIAVHS+KD+P E P+GL + +I +R D RD + L LP Sbjct: 62 WVKEIEDALLQKRIDIAVHSLKDLPTEQPEGLEVASIPKRVDARDVLIGKEGMKRLADLP 121 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGTSS+RR+ L RPDL + LRGN+ TRL+ L EYDAIILA AGL R + Sbjct: 122 QGARVGTSSVRRKAFLRAYRPDLQVIDLRGNIDTRLAALAGDEYDAIILAAAGLIRTEMR 181 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSR--TRELLAALNHHETALRVTAERAMNTRL 238 RI + P+I LPA GQGA+ +E R T E+ A++ H T R+TAER L Sbjct: 182 HRIDEFVEPDILLPAPGQGALALETRSGPENDLTIEVAYAIHDHGTDDRITAEREFLAGL 241 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GC P+G++A + G + L VGA DGS++IR G P + +G LA ++L G Sbjct: 242 GAGCMAPVGAHASIKGGVLTLEGWVGALDGSKVIRATSIGDPAECADIGAELAGDMLGQG 301 Query: 299 AREILAEVYN 308 A+ ++ Sbjct: 302 AQALIDAARE 311 >UniRef50_D1CBT4 Porphobilinogen deaminase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CBT4_THET1 Length = 300 Score = 367 bits (944), Expect = e-100, Method: Composition-based stats. Identities = 111/295 (37%), Positives = 170/295 (57%), Gaps = 2/295 (0%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 V+++ TR S LALWQ +V ++L + +PG E V + D D P++ +G G+F Sbjct: 2 KVIKVGTRGSKLALWQTQWVINRLRSLYPGFQFEPVVIKVTSDRSPDAPISAIGQVGVFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 K++E ALL +AVHS+KD+P G + EREDPRD + + L S Sbjct: 62 KDIEQALLAGDIHLAVHSLKDLPTLSTPGTVIAAFTEREDPRDCILWPKGQPMPDL-NNS 120 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGTSS+RR + P+ + +LRGNV TR+ K+ G YD +++A A +KR+ L Sbjct: 121 RVGTSSVRRSALVRSYWPNANVVNLRGNVDTRVRKMLEGNYDVVLMAYAAVKRMDLPVEF 180 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + LP + +P+ GQG + ++ R DD + +L A+N + + AER++ L GGC Sbjct: 181 K-PLPLDSWVPSAGQGIIAVQAREDDQQIIGMLNAINFFPSKVAYLAERSLMRALGGGCS 239 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 +P+G+YAEL DGE+ L +V APDGSQ++ R P A+ +G +A E+L+ G Sbjct: 240 MPVGAYAELHDGELSLIGMVAAPDGSQVVITRRVDTPDQADHLGERVAREMLDLG 294 >UniRef50_C3WGN0 Porphobilinogen deaminase n=5 Tax=Fusobacterium RepID=C3WGN0_9FUSO Length = 301 Score = 366 bits (941), Expect = e-100, Method: Composition-based stats. Identities = 122/311 (39%), Positives = 172/311 (55%), Gaps = 13/311 (4%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPL--AKVGGK 59 + + I +R S LAL QA VK+ L A++P L E+ +VT GD L + + K Sbjct: 1 MKRHVVIGSRGSILALAQASLVKNSLEANYPDLTFEIKEIVTSGDKDLKSNWENSNASLK 60 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 F KE+E LL+ + DIAVHSMKD+P P+GL I +RED RD +S N L L Sbjct: 61 SFFTKEIEQELLDGQIDIAVHSMKDMPAVSPKGLICGAIPDREDARDVLISKNG-FLVTL 119 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P G+ +GTSSLRR L RPD I+ LRGN+ TRL KL+ +YDAIILA AGLKR G+ Sbjct: 120 PQGAKIGTSSLRRVMNLKAIRPDFEIKHLRGNIHTRLKKLETEDYDAIILAAAGLKRTGM 179 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 +I L E PA QG + I+CR +D + +L ++++ + A V ER + + Sbjct: 180 ADKITEYLSGEAFPPAPAQGVLYIQCRENDEEIKGILKSIHNEDIAKIVEIEREFSKIFD 239 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GGC P+G Y+++ + +I A + DG Q R +D G +A + A Sbjct: 240 GGCHTPMGCYSQVDEDKIKFIAAY-SHDGKQ-----IRVVIEDDLTKGKEIA----HMAA 289 Query: 300 REILAEVYNGD 310 EI A++ G+ Sbjct: 290 EEIKAKINKGN 300 >UniRef50_Q3YSA8 Porphobilinogen deaminase n=17 Tax=Rickettsiales RepID=HEM3_EHRCJ Length = 298 Score = 365 bits (939), Expect = e-100, Method: Composition-based stats. Identities = 112/293 (38%), Positives = 175/293 (59%), Gaps = 3/293 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LAL Q V + L P + +++V + T GD+ P+ +GGKGLF+KE Sbjct: 3 IRIGTRGSVLALAQTLEVTNLLNRYFPEINIQVVKIKTSGDINNKVPINTIGGKGLFIKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E ALL + D+AVHS+KD+P + GL + + +R P D FVS+ Y S+ +LP + V Sbjct: 63 IEEALLIGKVDLAVHSVKDIPAFYCDGLIIPCVLKRSSPYDVFVSSKYQSIKSLPINATV 122 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR+ QL RPDL + +RGN+ TR+ K D GE+D I+LA AGL R+ + I+ Sbjct: 123 GTSSIRRKVQLNYLRPDLQVIPVRGNIDTRILKSDIGEFDGIVLAEAGLIRINKCNVIKE 182 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L +I L AVGQGA+ ++CR DD + LN H++ + V AER+ + G C P Sbjct: 183 VLDSKIMLSAVGQGAICVQCRADDYNIINKIKVLNCHKSYVCVIAERSFLKTINGSCDTP 242 Query: 246 IGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 + + A+ +D I++ ++ +++ + +AE+ GI + ++L+N Sbjct: 243 LAALAQYVDSDTIYMSCMLSNE--KEMVFSDCYFKECNAEESGIDMGKKLINE 293 >UniRef50_B0K2L4 Porphobilinogen deaminase n=7 Tax=Bacteria RepID=B0K2L4_THEPX Length = 299 Score = 364 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 110/296 (37%), Positives = 172/296 (58%), Gaps = 3/296 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + V+++ TR S LAL Q V +++ E+V + T+GD ++D P++++GGKG+ Sbjct: 1 MKKVIKVGTRSSELALKQTAMVINEIKKFRQDFEFEIVKITTQGDALIDKPVSEIGGKGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKE+E ALL+ D+AVHSMKD+P E P+GL L+ + +REDP+D FVS + L Sbjct: 61 FVKEIESALLKGEIDMAVHSMKDMPYEIPKGLKLMAVLKREDPKDVFVSGDGTQFMDLKE 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ +GTSSLRRQ QL +PD+ I +RGNV TRL K++ D I+L+ AGL RLGLE+ Sbjct: 121 GAKIGTSSLRRQVQLKALKPDIQIVPIRGNVRTRLKKMEELNLDGIVLSAAGLHRLGLEN 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLEG 240 I PP++ +PA QG + +E D+ +E + +T + ER + Sbjct: 181 IITEYFPPDVVVPAPCQGILAVEIAESFDNIFQEFYPYIVDRKTFFEASVERELLKAFGV 240 Query: 241 GCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 C+ P G+YA+ + E + V +++++ E G ++ ++M L EE Sbjct: 241 NCRQPFGAYAQYRKEEDEEKINIKVAYQKENKLLKSEVTGLIEETDKMIEKLIEEF 296 >UniRef50_UPI0000583C22 PREDICTED: hypothetical protein n=1 Tax=Strongylocentrotus purpuratus RepID=UPI0000583C22 Length = 324 Score = 363 bits (933), Expect = 4e-99, Method: Composition-based stats. Identities = 125/315 (39%), Positives = 179/315 (56%), Gaps = 13/315 (4%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 ++R+ +R+S LA+ Q ++V + L HP ++V M T GD I D PLA +G LF Sbjct: 6 EIVRVGSRKSELAMIQTNHVVEMLQKVHPETEFKIVTMETIGDHIQDKPLASIGESNLFT 65 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALP 120 KELE AL + D+ VHS+KD+P P + + ICEREDP DA V + S++ + Sbjct: 66 KELEKALALDEVDMLVHSLKDMPSRLPSNMAIGAICEREDPHDALVLHKKLTGISIETMK 125 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-YDAIILAVAGLKRLGL 179 GS++GTSS+RR QL + P L+ + +RGN+ TRL KLD G+ YD ++LAVAG+ R+G Sbjct: 126 EGSVLGTSSVRRVAQLKRKFPHLVFKDVRGNLNTRLRKLDEGQVYDGLVLAVAGMMRMGW 185 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 E RI L P+I +V QGA+GIE + + R ELL LNH T +R AER + LE Sbjct: 186 EHRISQILKPDICKYSVSQGALGIEIKTKNRRMHELLRQLNHVPTLIRCIAERGLLKTLE 245 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGA------PQDAEQMGISLAEE 293 GGC P+ ++EL + L A + + Q+AE +G+S+A+ Sbjct: 246 GGCSAPVAVHSELEENRHSLDAE---TNEEMKLFSSVIAPWVSQHAMQEAEALGVSVAKG 302 Query: 294 LLNNGAREILAEVYN 308 L + GA IL Sbjct: 303 LFDKGAGPILEAAKE 317 >UniRef50_C3XEZ5 Porphobilinogen deaminase n=3 Tax=Campylobacterales RepID=C3XEZ5_9HELI Length = 328 Score = 362 bits (929), Expect = 1e-98, Method: Composition-based stats. Identities = 146/315 (46%), Positives = 190/315 (60%), Gaps = 12/315 (3%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + L + TR S LALWQA+++K+KL + G V L + T+GD ILD PLAK+GGKGLF Sbjct: 12 EKPLVLGTRGSLLALWQANHIKEKLESL--GFQVVLKTIKTKGDKILDAPLAKIGGKGLF 69 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 KELE LL D AVHS+KDVP+ P L LV+I +RED RD FVS Y + +LP G Sbjct: 70 TKELENELLSGGIDFAVHSLKDVPIAIPPELMLVSITQREDARDCFVSEKYADIASLPQG 129 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 + VGT+SLRR QL R DL +SLRGNV TRL KL GE+DAIILA AGL RL L+ Sbjct: 130 AKVGTTSLRRSMQLKRIRQDLDTQSLRGNVQTRLEKLRKGEFDAIILASAGLNRLDLKDD 189 Query: 183 IRAA--LPPEISLPAVGQGAVGIECRL-------DDSRTRELLAALNHHETALRVTAERA 233 I L +PA+GQG++GIECR D ++L +L+ ++AL ERA Sbjct: 190 IGFISHLQINQFIPAMGQGSLGIECRDPKYSPDFRDQAIMKVLESLHDSKSALCCNIERA 249 Query: 234 MNTRLEGGCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAE 292 L GGCQ PIG +A+++D + I ++ +VG D S+++ R + E + Sbjct: 250 FIQLLGGGCQSPIGIHAQILDSKEIEIQCVVGNLDASKVLTETRVCNKGEVEYALQDMIN 309 Query: 293 ELLNNGAREILAEVY 307 L NG EIL EV Sbjct: 310 TLKKNGVMEILEEVR 324 >UniRef50_Q5HBG1 Porphobilinogen deaminase n=2 Tax=Ehrlichia ruminantium RepID=Q5HBG1_EHRRW Length = 299 Score = 360 bits (925), Expect = 3e-98, Method: Composition-based stats. Identities = 112/298 (37%), Positives = 177/298 (59%), Gaps = 3/298 (1%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M + + TR S LA+ QA VK L P + V++V +VT GD+ L+++GGKG Sbjct: 1 MNSMNVYVGTRGSILAIAQAMEVKKLLYNYFPDINVQIVHIVTSGDINDKISLSEIGGKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF+KELE ALL D+AVHSMKDVP + L + I +R P D F+S+ Y SL +LP Sbjct: 61 LFLKELEEALLTGTIDLAVHSMKDVPAFYCDSLVIPCILKRSSPYDVFISSKYQSLRSLP 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 +++GTSS+RR+ QL + + +RGNV TR+ KL+ G+YD IILA AGL R+ Sbjct: 121 DNAVIGTSSIRRKVQLMRLLSSVQVVPIRGNVDTRILKLEAGQYDGIILAKAGLMRINKT 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 I+ L P++ L AVGQGA+GI+CR +D + +++ LN ++ + V AER+ + G Sbjct: 181 HVIKEVLDPQVMLSAVGQGAIGIQCRANDYKMIDMIKILNCKKSYISVAAERSFMKTVNG 240 Query: 241 GCQVPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 C P+ + A+ ++ +++ ++ + + + + DAE GI++ +L++ Sbjct: 241 SCDTPLAALAKYVNSDTLYMSCMLSNEE--KTVFSDCYFNECDAEISGINMGNDLMDQ 296 >UniRef50_C6XGK7 Porphobilinogen deaminase n=1 Tax=Candidatus Liberibacter asiaticus str. psy62 RepID=C6XGK7_LIBAP Length = 307 Score = 359 bits (923), Expect = 6e-98, Method: Composition-based stats. Identities = 113/297 (38%), Positives = 162/297 (54%), Gaps = 2/297 (0%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGG 58 M RI TR SPLAL A + LM H P + ++P+ T+GD I + L ++GG Sbjct: 1 MEKKPFRIGTRCSPLALAHAFETRSSLMDVHKIPPHNIVIIPLSTKGDRITNRTLTEIGG 60 Query: 59 KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118 KGLF +E+E L+ D AVHS KD+P + +GL + RED RD F+S+ SL Sbjct: 61 KGLFTEEIEKKLISGEIDCAVHSAKDMPTKLLKGLQISAYLPREDIRDVFISHTAQSLKD 120 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 L S++GTSSLRR+ L R D+ + RG + TRL+KL+N + AI+LA AG+KRL Sbjct: 121 LALHSVIGTSSLRRKALLLRWRSDISVIDFRGKIETRLNKLNNNKAHAILLAYAGIKRLK 180 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 E I+ L E P+ GQGA+ IE +++ + +EL+ +NH +T V ERA L Sbjct: 181 KEKVIKEILNIEDFPPSPGQGAICIETHVNNPKAQELVKVINHEDTWDSVNCERAFLAEL 240 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295 +G C+ I +A ++ +V A DG R G DA +G A+ + Sbjct: 241 DGSCKSAIAGFAYCKGSTLYFYGIVLASDGKIFHEVSRNGNRCDAINIGRDAAQYIR 297 >UniRef50_Q2S2A6 Porphobilinogen deaminase n=1 Tax=Salinibacter ruber DSM 13855 RepID=Q2S2A6_SALRD Length = 323 Score = 359 bits (921), Expect = 1e-97, Method: Composition-based stats. Identities = 144/307 (46%), Positives = 192/307 (62%), Gaps = 5/307 (1%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + L + TR S LAL QA+ V+ +L A+ G VEL + TRGD DTP++++G + +F Sbjct: 4 SDPLVLGTRGSELALRQANVVRSRLEAA--GHRVELETITTRGDEATDTPISEIGDEAVF 61 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN--YDSLDALP 120 KEL+ ALL+ D+AVHS+KD+P P GL L I EREDPRDAFV++ L LP Sbjct: 62 TKELDRALLQGGVDLAVHSLKDIPSTVPSGLALAAIGEREDPRDAFVAHPSFDGHLHDLP 121 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ V T+SLRR QL R DL + +RGNV TRL KL ++ ++LAVAGL RLGL Sbjct: 122 EGATVATASLRRTAQLLTWRSDLEVVPVRGNVDTRLEKLGESDWTGMVLAVAGLVRLGLS 181 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLA-ALNHHETALRVTAERAMNTRLE 239 IR + P + +PAVGQGA+GI CR D R+LL L+H + AERA ++ Sbjct: 182 LHIRDRIDPSLIVPAVGQGALGIACREDQDALRDLLRETLHHAPSGHAANAERAFLKKVG 241 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GGCQVP+G++A + DG + L A + A DGS+ R ERR AP+D +G LA +LL G Sbjct: 242 GGCQVPLGAWAHIDDGTLVLDACIAALDGSEHYRDERRCAPEDGAAVGRKLAADLLAMGG 301 Query: 300 REILAEV 306 IL +V Sbjct: 302 DHILDDV 308 >UniRef50_D0NJW2 Porphobilinogen deaminase n=2 Tax=Phytophthora infestans T30-4 RepID=D0NJW2_PHYIN Length = 361 Score = 358 bits (919), Expect = 2e-97, Method: Composition-based stats. Identities = 124/320 (38%), Positives = 174/320 (54%), Gaps = 11/320 (3%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGK--- 59 + +++R+S LA+ Q + V L P L + T GD +LD L+ +G Sbjct: 13 KRTIFVSSRKSQLAMAQTNTVIAMLEERFPDLQFVVGQEDTVGDQVLDRHLSDLGTTTAS 72 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY------ 113 GLF K LE ALL A AVHS+KD+P P GL L I +RE P DA V + Sbjct: 73 GLFTKSLEEALLAKAASFAVHSLKDMPTTLPDGLVLAAITKRESPEDAAVIHPKHKEKGI 132 Query: 114 DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-YDAIILAVA 172 +L LP GS++GTSSLRR+ L + P I+++RGN+ TRL+KLD + YDAII+A Sbjct: 133 KTLQELPEGSVIGTSSLRREALLRSQFPTFEIKTVRGNIQTRLAKLDEHDDYDAIIVAAC 192 Query: 173 GLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232 G +R L RI LP + VGQG++G+ECR DD T E+L + ++A AER Sbjct: 193 GFRRGELGDRIDEILPMDTFGYGVGQGSIGVECRADDEETIEMLKTITDEKSAQLCKAER 252 Query: 233 AMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAE 292 ++ LEGGCQ+ +G A L + + L A V + DG + + G E++G LAE Sbjct: 253 SLLYHLEGGCQIAMGVSATLDEDTLTLNATVLSRDGKESVHETISGPRTQCEELGKQLAE 312 Query: 293 ELLNNG-AREILAEVYNGDA 311 NN AR++L + A Sbjct: 313 RFWNNELARKVLGKTRQKRA 332 >UniRef50_Q4HT06 Porphobilinogen deaminase n=1 Tax=Campylobacter upsaliensis RM3195 RepID=Q4HT06_CAMUP Length = 308 Score = 357 bits (917), Expect = 3e-97, Method: Composition-based stats. Identities = 151/305 (49%), Positives = 201/305 (65%), Gaps = 4/305 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L IATR+SPLALWQ+ +V D L +H G+ V L T+GD++LD+PLAK+GGKGLF Sbjct: 2 KKLIIATRKSPLALWQSEFVADILRKTH-GIEVHLEGFSTKGDILLDSPLAKIGGKGLFT 60 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE A+LEN+A +AVHS+KDVP PQGL L + RED DA +S Y L+ALP + Sbjct: 61 KELENAMLENKAHLAVHSLKDVPSFLPQGLVLAALSVREDDTDALLSELYKDLNALPQNA 120 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGT+SLRR+ QL RPDL I +LRGNV +RL +L GE+DAIILA AG+KRLGLES + Sbjct: 121 KVGTTSLRRKMQLLSLRPDLHIINLRGNVNSRLKRLKGGEFDAIILASAGVKRLGLESEV 180 Query: 184 RAA--LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + + +PA QG +GI+ D + LL LN ++ + T ER LEGG Sbjct: 181 KFIYRFSKDELVPAATQGILGIQS-PDKNEILTLLQCLNDEKSLIESTVERDFIRTLEGG 239 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 CQVPIG AEL+ +I +R+++G PDGS+I+R +R ++ + G LA E + GA+E Sbjct: 240 CQVPIGINAELMGEQITVRSILGLPDGSEILRDKRIILKKNYQGFGERLALEFIKRGAKE 299 Query: 302 ILAEV 306 +L Sbjct: 300 LLKRA 304 >UniRef50_C7N5L0 Porphobilinogen deaminase n=2 Tax=Slackia RepID=C7N5L0_SLAHD Length = 318 Score = 357 bits (917), Expect = 3e-97, Method: Composition-based stats. Identities = 121/313 (38%), Positives = 167/313 (53%), Gaps = 5/313 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + I TR S LALWQ V +M + P + VE+ T GD+ L +PLA++G KGL Sbjct: 1 MPERFVIGTRGSKLALWQTETVGRAIMRAFPEIEVEIRVRNTTGDINLASPLAEIGDKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDA 118 F +ELE LL D+ VHS+KD+ E P+G + + R D RD V SL Sbjct: 61 FTRELETDLLLGEVDMCVHSLKDLETEQPEGCVVAGVLPRADARDVLVCGPRIQAASLAE 120 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 +P GS +GT S RR QL P+++ +RGNV TR++K + +Y+ ILA AG+KR+G Sbjct: 121 VPEGSRIGTGSRRRVAQLKANFPNMVPEGIRGNVDTRVAKAEGDDYEGAILAAAGMKRMG 180 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 E I A LP E +PA GQGA+ +E + R ++ ALN T AER + L Sbjct: 181 YEDHIAAYLPIEDMIPAPGQGAIAMEVLKKNERAYQIARALNDPVTKACTDAERFVLFSL 240 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ--DAEQMGISLAEELLN 296 EGGC PIG++ L DG+ A V + G++ R D M + EL+ Sbjct: 241 EGGCSAPIGAHCRLEDGKYIFDACVLSLGGTKAARCHLEADADSADPMDMAWEVVSELIG 300 Query: 297 NGAREILAEVYNG 309 GAR IL ++ NG Sbjct: 301 EGARAILRDIKNG 313 >UniRef50_Q11XT5 Porphobilinogen deaminase n=8 Tax=Bacteria RepID=HEM3_CYTH3 Length = 312 Score = 354 bits (909), Expect = 2e-96, Method: Composition-based stats. Identities = 125/310 (40%), Positives = 172/310 (55%), Gaps = 4/310 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 ++ +RI TR S LALWQA +V L GL ++V + T GD ILD L+K+G KGL Sbjct: 1 MNKTVRIGTRGSKLALWQAEHVAACLQTK--GLEPQIVIIDTTGDKILDQSLSKIGSKGL 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F +ELE L DIAVHS KD+ G+ ++ I ERE D VS+ Sbjct: 59 FTEELEEQLHAGTIDIAVHSAKDLQTHLKGGMYILAITERELVNDVLVSHKPIDTLKNNP 118 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 I+GTSS RR+ L + P + +RGN+ TR+ K++ G DA++LA AG+ R+G +S Sbjct: 119 DLIIGTSSTRRRALLRKFYPQAKMVDMRGNLQTRIRKMEEGACDAMLLAYAGMHRMGYDS 178 Query: 182 RIRAALPPEISLPAVGQGAVGIECRL--DDSRTRELLAALNHHETALRVTAERAMNTRLE 239 I+ L E +PA GQG + IE D + + A LN T V+AERA LE Sbjct: 179 LIKEKLSLEEFIPAAGQGTLAIEAASTLDKEKAAVIRAVLNDAATETAVSAERAFLRTLE 238 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GGC +P+ + A D + L + + DG++ +R E R DAEQ G+ LA LL +GA Sbjct: 239 GGCSIPVFALAVERDTDYLLTGGIVSLDGTKYLRKEIRFTAADAEQRGVELATVLLKDGA 298 Query: 300 REILAEVYNG 309 EILAE+ G Sbjct: 299 DEILAEIKKG 308 >UniRef50_A6GB01 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=A6GB01_9DELT Length = 322 Score = 354 bits (909), Expect = 2e-96, Method: Composition-based stats. Identities = 138/309 (44%), Positives = 182/309 (58%), Gaps = 6/309 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 LR+ TR S LALWQA+ ++D+L+A+ GL VELV +VT+GD + D PL +VGG GL Sbjct: 9 RKLRLGTRGSALALWQANMIRDRLLAAWGAQGLEVELVRVVTKGDRVTDRPLNQVGGMGL 68 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD--SLDAL 119 FVK LE LL D AVHSMKD+P P+GL L + ER DPRDAF++ +L L Sbjct: 69 FVKGLEDKLLAGEIDFAVHSMKDMPGTLPEGLTLASTPERADPRDAFLAAPGRDVTLATL 128 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 PAGS +GTSSLRR P L I +RGNV TR+ K+ GE DA++LA AGL RLG Sbjct: 129 PAGSRLGTSSLRRGALAKRINPGLEIVPIRGNVPTRMGKIAEGEVDAVLLAAAGLDRLGK 188 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 I L P+ +PA QG + IE R D+ L L H T++ AER+ L+ Sbjct: 189 GEAITERLDPDAFMPAACQGVLAIELRAADTDIAALFEPLGHGPTSIVAAAERSYLATLQ 248 Query: 240 GGCQVPIGSYAELIDG--EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 GGCQVP+ +A L + + + LV PDGS + E G DA Q+G +A E+L Sbjct: 249 GGCQVPLACHARLSEDGRRVRVEGLVVEPDGSTVYASEAEGPVADAAQLGAGVAREVLAA 308 Query: 298 GAREILAEV 306 G + ++ + Sbjct: 309 GGQGVIDRL 317 >UniRef50_A6DBT5 Porphobilinogen deaminase n=1 Tax=Caminibacter mediatlanticus TB-2 RepID=A6DBT5_9PROT Length = 295 Score = 354 bits (909), Expect = 2e-96, Method: Composition-based stats. Identities = 132/296 (44%), Positives = 177/296 (59%), Gaps = 8/296 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 L IATR S LALWQA +VK +L G V+L + T GD ILD PLA +GGKGLF+K Sbjct: 2 KLTIATRGSKLALWQAEWVKKRLENL--GHEVDLKIVTTTGDKILDKPLASIGGKGLFIK 59 Query: 65 ELEVALLENRADIAVHSMKDVPVEF-PQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 E+E ALL A IAVHS+KD P E+ + L + +RE D F+S +++L LP + Sbjct: 60 EVEEALLRGEAQIAVHSLKDFPTEYNKEHFTLAAVPKREAVEDVFLSETFETLAELPHNA 119 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL--ES 181 +VGTSS+RR QL R DL+I LRGNV TR++KL GEYDAIILA AG+KRL L E Sbjct: 120 VVGTSSIRRAMQLKAFREDLVISDLRGNVDTRINKLKKGEYDAIILAYAGVKRLNLIKEV 179 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + L +I +PA+GQGA+GIE + D + E + LN T + VT ER L G Sbjct: 180 KYFEILDTDIMIPAMGQGALGIET-IKDEKVIEAVKPLNDLWTKIEVTIERDFIDELNLG 238 Query: 242 CQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 C P+G A++ +D I ++A + + +++I+ E + E G AEE Sbjct: 239 CHAPVGVNAKIMVDDSIKIKAAILDKN-NKVIKKEMVVPFDEWENAGREFAEEFKE 293 >UniRef50_A8U3E9 Porphobilinogen deaminase n=1 Tax=alpha proteobacterium BAL199 RepID=A8U3E9_9PROT Length = 321 Score = 353 bits (906), Expect = 6e-96, Method: Composition-based stats. Identities = 131/306 (42%), Positives = 178/306 (58%), Gaps = 7/306 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLV--VELVPMVTRGDVILDTPLAKVGGKGLFV 63 L + +R SPLAL Q H V+D+L A+ P L + + + T GD + D PLA++GGKGLF+ Sbjct: 15 LTLGSRGSPLALRQTHEVRDRLAAAWPELAGAIAVQEIRTTGDAVRDRPLAEIGGKGLFI 74 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE+E AL+ + D AVHSMKD+ LV + REDPRDA++S D +D LP+G+ Sbjct: 75 KEIEQALMAGQIDAAVHSMKDMETTIAPASVLVAVLPREDPRDAWLSPIADRVDDLPSGA 134 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +GT+S+RR Q+ RRPDL + RGNV TRL KL GE LA AGL RLG+ + Sbjct: 135 KIGTASVRRAAQVLNRRPDLQVVLFRGNVDTRLRKLAEGEVAGTFLAAAGLSRLGMLDKA 194 Query: 184 RAALPPEISLPAVGQGAVGIECRLD-----DSRTRELLAALNHHETALRVTAERAMNTRL 238 L + LPAV QGA+G++CR D+ R L+ L+ + LRVTAERAM L Sbjct: 195 TRILEVDEMLPAVSQGAIGVQCRDGEASARDAEIRNWLSILDDRPSRLRVTAERAMLATL 254 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 +G C+ PI +A L + L +V + DG A D E +G ++ E +L G Sbjct: 255 DGSCRTPIAGHATLGGARLTLSGMVFSLDGQSSHGAVDTSATDDPEALGRTVGEAILARG 314 Query: 299 AREILA 304 R LA Sbjct: 315 GRNFLA 320 >UniRef50_B3U3W9 Hydroxymethylbilane synthetase n=1 Tax=Oxyrrhis marina RepID=B3U3W9_OXYMA Length = 395 Score = 352 bits (904), Expect = 9e-96, Method: Composition-based stats. Identities = 129/303 (42%), Positives = 168/303 (55%), Gaps = 3/303 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMA-SHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR SPLAL QA V+ + G +++ + T GD ILD LA VGGKGLF K Sbjct: 76 LRIGTRGSPLALAQARDVESRAREQLQQGGEIDICVISTEGDRILDRALADVGGKGLFTK 135 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 EL+ ALL D VHSMKDVP G +V RED RD F+S Y +L LP G++ Sbjct: 136 ELDRALLSGEVDCCVHSMKDVPTTVAPGTEIVAYLPREDTRDVFLSAKYATLADLPDGAV 195 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGT+SLRRQ Q+ + ++++ + RGNV TRL KL G D LA AGLKRLG+ + Sbjct: 196 VGTASLRRQAQILAQ-KNVVVTNFRGNVQTRLRKLAAGTVDCTFLAYAGLKRLGMLAEAT 254 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L LPA+ QGAVGI+ R +D+ R L+ L+H T L V ERA L+G C+ Sbjct: 255 QVLEWSDMLPAIAQGAVGIQIRSNDAALRGTLSQLDHEPTRLAVETERAFLRALDGSCRT 314 Query: 245 PIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 PI A + D + R V + DG Q P D ++G +L ++L E Sbjct: 315 PIAGQAWIGPDSRLAFRGQVLSADGKQRFERVGDCLPCDGPELGKTLGDDLRREAGEEFF 374 Query: 304 AEV 306 AE+ Sbjct: 375 AEL 377 >UniRef50_A6GVP0 Hydroxymethylbilane synthase n=18 Tax=Bacteroidetes RepID=A6GVP0_FLAPJ Length = 308 Score = 352 bits (903), Expect = 1e-95, Method: Composition-based stats. Identities = 111/311 (35%), Positives = 173/311 (55%), Gaps = 8/311 (2%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M ++I TR S LALWQAH+V+ L G +++ + ++GD+ILD PL ++G G Sbjct: 1 MAKKTIKIGTRDSELALWQAHHVEKMLNDL--GHKTKIIAVKSQGDIILDKPLYELGITG 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 +F K L++A++ DIAVHSMKDVP PQG+ + ER + +D V NN +LD L Sbjct: 59 IFTKTLDIAMVNGDIDIAVHSMKDVPTALPQGIVQAAVLERANEKDILVYNN--NLDFLN 116 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 + + T SLRRQ Q + P+ + LRGNV TR+ KL + ++ + A AGL+R+ ++ Sbjct: 117 TQATIATGSLRRQAQWLHKYPNHKVVDLRGNVNTRMQKLQDNNWNGAVFAAAGLERINIK 176 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 + + +PA QGA+ + +D+ + LA LNH ET + ER LEG Sbjct: 177 PE--NYINLDWMIPAPAQGAMMVVAMGNDTYCLDALAELNHIETEITTYIERQFLRTLEG 234 Query: 241 GCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GC PIG+YA D I + ++ + DGSQ I ++ Q+ +Q+G +E+ NG Sbjct: 235 GCTAPIGAYARFNEKDETIHFQGVLFSLDGSQKIEIKKIVEIQEWKQLGYHAGQEIFENG 294 Query: 299 AREILAEVYNG 309 +++ + Sbjct: 295 GVQLMKTIKEK 305 >UniRef50_C4Z552 Porphobilinogen deaminase n=8 Tax=Bacteria RepID=HEM3_EUBE2 Length = 295 Score = 350 bits (900), Expect = 2e-95, Method: Composition-based stats. Identities = 123/291 (42%), Positives = 166/291 (57%), Gaps = 5/291 (1%) Query: 7 RIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66 RI TR S LAL Q+ YVK ++ ++P ELV + T GD + D PLA +G KG FVKE+ Sbjct: 4 RIGTRGSKLALVQSEYVKRRMEEAYPEDTFELVIIKTTGDKVTDKPLAAIGTKGFFVKEI 63 Query: 67 EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126 E ALL D+AVHSMKD+P E GL +RED RD + S LP+G+++G Sbjct: 64 EEALLSGSIDMAVHSMKDMPAECAAGLTFAKAWKREDCRDVLILKTAGSFSELPSGAVIG 123 Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY--DAIILAVAGLKRLGLESRIR 184 T SLRR CQLA RPD+ ++RGNV TR++KL + Y D I+LA AGL RLG S I Sbjct: 124 TGSLRRACQLAMLRPDIQFTAIRGNVDTRINKLMDDSYGLDGIVLAAAGLNRLGRSSEIT 183 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L PE+ +PA QG + IE ++ + + AL+ + AER GGC Sbjct: 184 EYLDPEVVIPAPAQGVLAIETAEVNTELLDKINALSDDNSDREAVAERTFLRLTGGGCHA 243 Query: 245 PIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 P+G++ D G++ + L G D S+I+R E G D+E +G A L Sbjct: 244 PVGAHCVTKDNGDLRMVVLFGNDDCSRILRIEVTGT--DSEAVGHEAARML 292 >UniRef50_B2W5W6 Porphobilinogen deaminase n=2 Tax=Pleosporineae RepID=B2W5W6_PYRTR Length = 399 Score = 350 bits (900), Expect = 2e-95, Method: Composition-based stats. Identities = 128/348 (36%), Positives = 177/348 (50%), Gaps = 45/348 (12%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG----KG 60 + I TR S LA QA V+ L ++P + P++ +GD TPL ++ K Sbjct: 30 PVNIGTRNSVLAQIQARAVERSLKDAYPERTYNICPVIVQGDRDKITPLQQLSQGENAKS 89 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS----NNYDSL 116 L+ ELE L DI VH +KD+P + P L L I EREDPRDA + +L Sbjct: 90 LWTGELESMLESGDLDIIVHCLKDMPTQLPDHLELGAILEREDPRDALLVSPRLPKETTL 149 Query: 117 DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAGL 174 LP G+ +GTSS+RR L + P L LRGNVGTRL+KLD + Y AIILA AGL Sbjct: 150 ATLPQGATIGTSSVRRAATLRKLYPHLKFADLRGNVGTRLAKLDAEDSPYSAIILAAAGL 209 Query: 175 KRLGLESRIRAALPPEI--SLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232 KR+GL++RI L L AVGQGA+GIE R +D +EL++ + T +AER Sbjct: 210 KRMGLDNRITQYLSSTSGGMLHAVGQGALGIEIRKNDEAMKELMSKIRCERTTRACSAER 269 Query: 233 AMNTRLEGGCQVPIGSYAELIDGE------------------------------IWLRAL 262 A+ LEGGC VPIG G+ + +RA+ Sbjct: 270 ALLRTLEGGCSVPIGVETSWKGGKGLSVGPQPAKDYDKHGNAVEEDEPDVDDQELVMRAM 329 Query: 263 VGAPDGSQIIRGERR---GAPQDAEQMGISLAEELLNNGAREILAEVY 307 V + DG + + E ++AE+MG +A+ L+ GA +IL ++ Sbjct: 330 VVSVDGKESVEYEATRKVRNAEEAEEMGREVAKILIEKGADKILEKIN 377 >UniRef50_UPI00006CBE06 porphobilinogen deaminase family protein n=1 Tax=Tetrahymena thermophila RepID=UPI00006CBE06 Length = 362 Score = 350 bits (899), Expect = 4e-95, Method: Composition-based stats. Identities = 123/339 (36%), Positives = 178/339 (52%), Gaps = 32/339 (9%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKL----MASHPGLVVELVPM--------------- 41 + + +IA+R S LAL Q + V D L E+VP+ Sbjct: 16 LKNRKFKIASRSSQLALSQTYEVIDLLVGVKELGLTKENFEVVPISNAPGKNCTLKFKIN 75 Query: 42 ------VTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGL 95 +GD L PL +GG G+F K +EV LL DIAVHS+KD+P + L + Sbjct: 76 ITNKQFTNKGDQNLKDPLYVMGGVGVFTKIVEVELLNKNGDIAVHSLKDLPTIIDERLFI 135 Query: 96 VTICEREDPRDAFVS---NNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNV 152 + + D + + L LP GS++GTSSLRR L R P L ++RGN+ Sbjct: 136 GAVPPLKPRGDVVIFNEKHKGKELKDLPEGSVIGTSSLRRITNLKNRYPHLKYENIRGNL 195 Query: 153 GTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRT 212 TRL+KL+NG+YDAIILA AG+ RLG ++ L E L A GQGA+G++CR DD Sbjct: 196 NTRLTKLENGQYDAIILAEAGVFRLGWIEKVGQFLKQEDFLYAPGQGALGVQCRADDKEA 255 Query: 213 RELLAALNHHETALRVTAERAMNTRLEG---GCQVPIGSYAELIDGEIWLRALVGAPDGS 269 LL+ +N E +RV AER +LEG GC++PI ++E+ID + L V + + Sbjct: 256 IALLSYINQKEPRIRVDAERQFLNKLEGVILGCKLPIAVHSEIIDQTLRLTGQVWSLEAD 315 Query: 270 QIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYN 308 + IR G D + +G+ L+E++ GA EIL ++ + Sbjct: 316 KTIREVIEGHISD-QDLGLKLSEKMKQAGAGEILEKIRS 353 >UniRef50_C6WZF5 Porphobilinogen deaminase n=1 Tax=Flavobacteriaceae bacterium 3519-10 RepID=C6WZF5_FLAB3 Length = 311 Score = 350 bits (898), Expect = 4e-95, Method: Composition-based stats. Identities = 107/307 (34%), Positives = 172/307 (56%), Gaps = 7/307 (2%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 ++I TR SPLALWQA V L + ++ P++++GD L PL +G G+F Sbjct: 10 RSIKIGTRNSPLALWQAREVARHLQNN--NHTTDITPIISKGDKNLSQPLYTLGITGIFT 67 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 K+L++ALL N DIAVHS+KD+P + P+ + ++ + +R+ P+D V + L Sbjct: 68 KDLDIALLNNEVDIAVHSLKDIPTQLPENVEIIAVLQRDYPQDVLVRKKDAATLELHQ-L 126 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 + TSSLRR+ + P +RGNV TRL+KL+ ++DA + ++A ++R+GL Sbjct: 127 KIATSSLRRRAFWLKEFPGTEFSDIRGNVQTRLTKLEENDFDATMFSLAAIERMGLSVD- 185 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + +PA QG V + R +D +EL +NH ET + + ER+ + LEGGC Sbjct: 186 --YEHLPLMIPAPAQGVVAVCARSNDPEIKELFKEINHRETRICIDIERSFLSTLEGGCT 243 Query: 244 VPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 PIG++AE+ D GE+ + + DG I + A + + G LAE++L NG RE+ Sbjct: 244 APIGAFAEINDLGEVRFTGRICSLDGQNCIETDEIFAWNEHDDFGKILAEKILQNGGREL 303 Query: 303 LAEVYNG 309 + E+ + Sbjct: 304 MQEIKSK 310 >UniRef50_A9FDP9 Porphobilinogen deaminase n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=HEM3_SORC5 Length = 300 Score = 349 bits (897), Expect = 6e-95, Method: Composition-based stats. Identities = 152/299 (50%), Positives = 196/299 (65%), Gaps = 4/299 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + L +ATR+S LAL Q+ L A+ P L + + +VT GD D L +GGKGL Sbjct: 1 MPTELTLATRRSALALAQSRAFARSLEAAVPDLSLRELEVVTSGDKTQDRSLQDIGGKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F+KELE ALL+ RAD AVHS+KDVP E L L I REDPRDA V+ + L LPA Sbjct: 61 FIKELEEALLDRRADFAVHSIKDVPAEIAPALCLACIPAREDPRDALVTRSGALLAELPA 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ VGTSSLRR L E RPDL+I +RGNV TRL K+ +G +DA++LA+AGLKRLGLE+ Sbjct: 121 GARVGTSSLRRAVALREARPDLVIEPVRGNVDTRLRKVFDGVFDAVVLALAGLKRLGLEA 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 R L PE+SLPA+GQGA+GIECR D R++L L ET + V+AERA+ +EG Sbjct: 181 RATEVLSPEVSLPAIGQGALGIECRTADDSVRDVLGTLADAETTICVSAERAVMAAVEGS 240 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR----GAPQDAEQMGISLAEELLN 296 C+ P+ +YA G +WLRAL+ PDGS++ R ERR G ++AE++G L EL Sbjct: 241 CRTPVAAYAVRDGGALWLRALLAEPDGSRLRRAERRLSWPGNTREAERLGADLGAELKK 299 >UniRef50_A3CL78 Porphobilinogen deaminase n=1 Tax=Streptococcus sanguinis SK36 RepID=HEM3_STRSV Length = 306 Score = 347 bits (892), Expect = 2e-94, Method: Composition-based stats. Identities = 126/300 (42%), Positives = 179/300 (59%), Gaps = 7/300 (2%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 V+++ TR+S LA+ Q + D+L A HP LVP T+GD + L ++GGKG+FV Sbjct: 2 KVIKVGTRKSKLAMTQTQQLVDQLKALHPERDFVLVPYTTKGDRLTHVSLQEIGGKGVFV 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALPAG 122 KE+E ALL ++AVHS+KD+P + +G L I +RED RD + +L LP G Sbjct: 62 KEIERALLAGEINMAVHSLKDMPAKLAEGCALGAISQREDVRDCLIFRQAGQTLADLPKG 121 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 S++GTSS+RRQ QL +RPDL + LRGN+ TR+ KL+ GEYDAI+LA+AGLKRLG + Sbjct: 122 SLIGTSSIRRQVQLQAQRPDLAFKPLRGNIDTRIKKLEEGEYDAIVLAMAGLKRLGWLDQ 181 Query: 183 IR---AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 R L + LPA+ QGA+ +ECR +D LLAA+ +TA V ERA+ ++ Sbjct: 182 SRLHIQPLETSLCLPAISQGALAVECREEDEELLSLLAAVQDEKTAAEVAVERAVLAQMN 241 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 C PI ++A+ L A++ DG Q I +G QD +Q+ +L + GA Sbjct: 242 ADCTFPIAAFAQKNGQGYQLEAMLAKEDG-QCIFVSLQG--QDGQQLAEQAVRQLADKGA 298 >UniRef50_Q1V167 Hydroxymethylbilane synthase n=3 Tax=Candidatus Pelagibacter RepID=Q1V167_PELUB Length = 307 Score = 347 bits (891), Expect = 3e-94, Method: Composition-based stats. Identities = 111/300 (37%), Positives = 168/300 (56%), Gaps = 3/300 (1%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVE---LVPMVTRGDVILDTPLAKVG 57 M + + I +R S LAL A ++K++ +E + +VT+GD + D L++VG Sbjct: 1 MKNRKIIIGSRGSKLALIYAEKAREKILKHSKDFGIEEVIIKEIVTKGDQVQDKRLSEVG 60 Query: 58 GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD 117 GKGLF K +EV LLE + DIAVH++KD+P E +GL ER DPR+ +S + L Sbjct: 61 GKGLFSKTIEVELLEKKIDIAVHALKDMPSEETRGLLTDCFLERNDPREILISKDNKHLK 120 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177 L + SI+GTSS RR+ Q+ + R DL + +RGNV TR+ KL YDAIIL+ AG+ L Sbjct: 121 DLASNSIIGTSSYRREFQIKKIRDDLNCKLIRGNVDTRIRKLKENLYDAIILSYAGIDSL 180 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 GL I +P GQG + ++CR +D ELL ++H T + AER + Sbjct: 181 GLNQNISQTFSTSEIIPCAGQGVIALQCRDNDESLIELLKQVDHQSTHSSIKAERNVLKV 240 Query: 238 LEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 LEG C+ +G++A + +I L + + DGS+ + + AE++GI + + L Sbjct: 241 LEGDCETAVGAFANIEGNKINLEVELFSLDGSKRFYLKSSESVDKAEELGIEMGKTLKKM 300 >UniRef50_A0LRF1 Porphobilinogen deaminase n=1 Tax=Acidothermus cellulolyticus 11B RepID=HEM3_ACIC1 Length = 331 Score = 347 bits (890), Expect = 4e-94, Method: Composition-based stats. Identities = 128/313 (40%), Positives = 165/313 (52%), Gaps = 6/313 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +VLR+ TR+S LA Q + L A+ G VE+V + + GD D PL + G G+FV Sbjct: 8 SVLRLGTRRSTLARAQTEEIAGALRAA--GCRVEIVGIQSTGDRHADVPLHEFAGSGVFV 65 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 EL ALL D+ VHSMKD+P L + I R DPRDA V+ L LP G+ Sbjct: 66 AELRAALLRGEVDVVVHSMKDLPTAEIPELAIAAIPRRADPRDALVTGAGCRLAELPTGA 125 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 IVGT S RR QL RPDL IR +RGN+ TRL KL G Y A+I+A AGL RL Sbjct: 126 IVGTGSPRRAAQLRLLRPDLEIRPIRGNLDTRLGKLHAGGYAALIVAAAGLARLHRSEEA 185 Query: 184 RAALPPEISLPAVGQGAVGIECRLDD----SRTRELLAALNHHETALRVTAERAMNTRLE 239 P + LPA GQGA+ +ECR D R +LA L+ T VTAERA+ + Sbjct: 186 AEFFDPTVMLPAPGQGALAVECRRADIADGGRLAGILAGLDDPATRAAVTAERALLAAVG 245 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GC P+G+ + + L A+V P G+ R G P DA +G LA +L+ GA Sbjct: 246 AGCSAPVGALGVVTADTLQLDAVVVDPSGTTAFRRSLTGTPDDASDLGRRLAADLIRAGA 305 Query: 300 REILAEVYNGDAP 312 ++L P Sbjct: 306 DQLLQAPKQTGEP 318 >UniRef50_A2Q9P7 Catalytic activity: 4 porphobilinogen+H(2)O<=>hydroxymethylbilane+4 NH(3) n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2Q9P7_ASPNC Length = 346 Score = 345 bits (887), Expect = 9e-94, Method: Composition-based stats. Identities = 120/324 (37%), Positives = 173/324 (53%), Gaps = 22/324 (6%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG-----KG 60 LR+ TR S LAL QA +V +L ++HPG+ +V RGD +P K G K Sbjct: 12 LRLGTRNSKLALVQAEHVSKELTSAHPGVQFPWQTVVVRGDADKSSPFLKFAGPSDAAKN 71 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-----DS 115 ++ +E+E L D+ VH +KD+P P+ L I REDP DA V Sbjct: 72 IWTEEMETKLCAGELDLLVHCLKDMPTRLPETCTLGAIVYREDPTDALVIKEGLRSQYTD 131 Query: 116 LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAG 173 L LP GS+VGTSS RR+ L R P L + RGN+GTRL KLD+ E + AIILA AG Sbjct: 132 LSQLPPGSVVGTSSTRRKALLRYRYPHLKVEECRGNLGTRLKKLDDPEGPFSAIILATAG 191 Query: 174 LKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERA 233 + R+ LE RI LPP AVGQGA+GIE R +D++T+ ++ + T AER+ Sbjct: 192 MVRINLEDRITKRLPPSEFPYAVGQGALGIEIRKEDAQTKTMVRKIEDLVTRRICLAERS 251 Query: 234 MNTRLEGGCQVPIGSYAELID-------GEIWLRALVGAPDGSQIIRGERR---GAPQDA 283 + L+GGC P+ + + ++ L + P G+ ++ G +DA Sbjct: 252 LLRTLQGGCSSPVAVHCTVEQAPTASSPAQLRLDGTIIHPHGTTLLSERTTAEVGTDEDA 311 Query: 284 EQMGISLAEELLNNGAREILAEVY 307 E +G ++A++LL NG + +L E+ Sbjct: 312 EALGATVAQQLLKNGGQALLEEIR 335 >UniRef50_C0YV01 Hydroxymethylbilane synthase n=1 Tax=Chryseobacterium gleum ATCC 35910 RepID=C0YV01_9FLAO Length = 302 Score = 344 bits (884), Expect = 2e-93, Method: Composition-based stats. Identities = 110/305 (36%), Positives = 167/305 (54%), Gaps = 6/305 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +RI TR S LALWQA V L + + E+VP+V+ GD L+ PL +G G+F Sbjct: 2 KSIRIGTRNSALALWQAREVARHLQNN--NYLTEIVPIVSSGDKNLNQPLYSLGITGVFT 59 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 ++L++ALL + DIAVHS+KDVP + PQ + ++ ER+ P+D + Sbjct: 60 RDLDIALLNDEIDIAVHSLKDVPTQLPQNIEMIAYLERDYPQDILIRKESSRNKEFHE-L 118 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 + TSSLRR+ P +RGN+ TRL KL+ G++DA IL++AG+KR+ +E Sbjct: 119 KLATSSLRRRAFWLRNYPTAEFSDIRGNIQTRLQKLEEGDFDATILSLAGIKRMKMEIDY 178 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 LP + A QG + + D E++ +NH ET + V ER + LEGGC Sbjct: 179 -EMLPL--MISAPSQGVISVAGHTDKPEINEIVRQINHQETQICVEIERNFLSTLEGGCT 235 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 PIG++AE+I +I +A + + DG I + AE G A+ +L NG +E++ Sbjct: 236 APIGAFAEIIGDQIRFKAALCSLDGKNCIAVDENFVYTPAENFGEKYAKVVLENGGKELM 295 Query: 304 AEVYN 308 AE+ + Sbjct: 296 AEIKS 300 >UniRef50_Q0TQG4 Porphobilinogen deaminase n=32 Tax=Clostridium RepID=HEM3_CLOP1 Length = 291 Score = 344 bits (883), Expect = 2e-93, Method: Composition-based stats. Identities = 128/292 (43%), Positives = 170/292 (58%), Gaps = 4/292 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L IATR+S LA Q V + L + + + ++T GD LD L K+GGKGLFVKE Sbjct: 3 LIIATRKSKLAQVQTEKVMELLKEKE-NVDSKKLLVMTEGDRRLDVSLNKIGGKGLFVKE 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 +E+ALL A AVHSMKDVP E P LV + ERED RDAFVS N +L L G+ + Sbjct: 62 IELALLNKEAHGAVHSMKDVPFELPSEFELVAMPEREDIRDAFVSLNGSTLSNLRKGARI 121 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR QL R DL I +RGNV TR+ K+ D IILA AGLKRLG+E I Sbjct: 122 GTSSIRRAEQLKLFRDDLEIVPIRGNVQTRIKKITEENLDGIILAAAGLKRLGMEDVISD 181 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 P++ LPA+GQGA+GIEC + AL+ E V AER+ L GGC Sbjct: 182 YFDPKVFLPAIGQGALGIECLKGG-EFNDYFKALDSKEVRTTVEAERSFMKVLNGGCHSL 240 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 IG+Y+E+ D ++++ + +I++ + G +D +G LAE++L Sbjct: 241 IGAYSEVKDNDLYMIGTFTVNN--RIVKKDILGNKEDNILLGKKLAEKILGE 290 >UniRef50_C3PNS9 Porphobilinogen deaminase n=15 Tax=Rickettsia RepID=HEM3_RICAE Length = 351 Score = 343 bits (882), Expect = 4e-93, Method: Composition-based stats. Identities = 105/254 (41%), Positives = 155/254 (61%), Gaps = 1/254 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + N +RI TR+SPLAL + V ++ P + E+VP++T GD+I + PL +GGK L Sbjct: 1 MTNSIRIGTRKSPLALIHTNLVIQQIKQFFPDINCEIVPIITSGDLIQNKPLYDIGGKAL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F+KE+E ALL+ + D+AVHS+KDVP P+ L + + EREDPRD FV Y S++ LP Sbjct: 61 FLKEIEQALLDKKIDLAVHSLKDVPGRIPEPLVIAAVLEREDPRDVFVCLKYKSIEELPQ 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG-LE 180 +++G+S++RR+ + + RPDL + RGNV +R+ KL GE DA ILA GLKRL Sbjct: 121 NAVIGSSAVRRKAFIQKIRPDLKVTVFRGNVDSRIKKLMTGEVDATILAYTGLKRLEVFN 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 + LP +GQG + +E R DD+ E+ +NH T + ERA L+ Sbjct: 181 PEYCHLIEYSQMLPCIGQGVIAVEIRKDDNAMLEICNQINHLPTFELIKPERAFLEYLDA 240 Query: 241 GCQVPIGSYAELID 254 C+ PI +Y++ +D Sbjct: 241 NCRTPIAAYSQYLD 254 >UniRef50_C1AA38 Porphobilinogen deaminase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1AA38_GEMAT Length = 309 Score = 343 bits (881), Expect = 5e-93, Method: Composition-based stats. Identities = 151/311 (48%), Positives = 186/311 (59%), Gaps = 6/311 (1%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M+ +RI TR S LAL QA V +L A G+ ELV T GD ILD PL+ +G KG Sbjct: 1 MMTVPVRIGTRSSELALRQARQVAAQLDAR--GVPSELVEYTTLGDRILDRPLSAIGEKG 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLD 117 LF ELE LL R D AVHS+KD+P PQG+ +V + EREDPRDA V SLD Sbjct: 59 LFTAELEADLLAGRIDCAVHSLKDLPTADPQGIIVVALLEREDPRDALVVRAGVDAHSLD 118 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177 LP G+ VGTSSLRR+ QL R DL + LRGNVGTRL KLD G+ DA +LA AGL RL Sbjct: 119 TLPEGARVGTSSLRRRAQLQALRSDLEVCELRGNVGTRLRKLDEGQVDAALLAAAGLHRL 178 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 GL RI A L L A GQGA+ ++ R DD L++L+H T + VTAERA+ Sbjct: 179 GLADRIVAYLDAPEWLSAPGQGAIAVQGRADDEALLSTLSSLDHAPTRVAVTAERALLAA 238 Query: 238 LEGGCQVPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 LEGGCQVPIG+ E + L A++ + DGS +RG + GI LA +L Sbjct: 239 LEGGCQVPIGAAVLEEPEYGTILHAVIVSLDGSSAVRGGYPVDHANPAASGIELARQLRA 298 Query: 297 NGAREILAEVY 307 G +IL+E+ Sbjct: 299 AGGAQILSEIR 309 >UniRef50_A8MDU3 Probable porphobilinogen deaminase n=2 Tax=Thermoproteaceae RepID=HEM3_CALMQ Length = 305 Score = 343 bits (880), Expect = 5e-93, Method: Composition-based stats. Identities = 124/304 (40%), Positives = 180/304 (59%), Gaps = 2/304 (0%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 ++RIATR S L+L Q V D+++ + + +L+ + T GDV L PL ++G KG+F + Sbjct: 2 IIRIATRGSALSLKQTKIVMDRILEFNKDVEFKLIIVKTTGDVDLSKPLYEIGVKGIFER 61 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E+ A+L AD+AVHS+KD+P + L LV R++PRDA VS ++D LP SI Sbjct: 62 EVNQAVLRGEADVAVHSLKDMPAQISNDLTLVMTPPRDNPRDALVSLRQYTVDTLPLNSI 121 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGTSSLRR+ L R D+ ++ +RGNV TR+ KL+NGEYDA+I+A AGL+RL + + + Sbjct: 122 VGTSSLRRRGFLLSLRRDVTVKPIRGNVDTRIRKLNNGEYDALIMAAAGLERLSINANVS 181 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 + PE+ PA GQG +G+ R D ++L + ET AERA +R+ GC V Sbjct: 182 E-ISPELMPPAPGQGIIGVVARRDRDDLIKVLRRSSDEETFKEAAAERAFLSRIGAGCHV 240 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 P+G A L DG V PDG + R ++ E+ G AE+LL N AR ++A Sbjct: 241 PLGGLALLDDGYFDFTYGVVDPDGVEKFINSTRIDARNPEEAGRVAAEDLLRN-ARGLVA 299 Query: 305 EVYN 308 + Sbjct: 300 RLLK 303 >UniRef50_C1ZK04 Porphobilinogen deaminase n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZK04_PLALI Length = 318 Score = 342 bits (879), Expect = 8e-93, Method: Composition-based stats. Identities = 139/315 (44%), Positives = 181/315 (57%), Gaps = 16/315 (5%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 VLRIATR S LALWQA++V D L + P L VELV + T GD + PL + GG+G+F + Sbjct: 3 VLRIATRASQLALWQANFVADSLRSLDPELTVELVHVTTTGDRVQGEPLRQFGGQGVFTR 62 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS----LDALP 120 E++ ALLE RADIAVHS+KD+P GL L + R DA + S L LP Sbjct: 63 EVQAALLEGRADIAVHSLKDLPTVPTAGLELAAVPARAPVADALLLPTGHSGPASLAMLP 122 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GT S RRQ QL RPDL+ +RGN+ TR+ KLD GEY+ +ILAVAGL RLG Sbjct: 123 RGARIGTGSPRRQAQLLRIRPDLVCSEVRGNLDTRIRKLDAGEYEGLILAVAGLSRLGWS 182 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 RI L P PA GQGA+G+ECR D T ++ L +T L V AERA+ LE Sbjct: 183 DRISLILAPPTMFPAAGQGALGLECRHGDEATIRWVSQLEDRQTRLAVDAERAVLRTLEA 242 Query: 241 GCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRG--ERRGAPQD---------AEQMGI 288 GC P+G++A + L A++ APDGS+ + +G A ++G Sbjct: 243 GCHAPVGTWASWKSPETLHLEAILIAPDGSETLAAASSMQGPLSQYGSGNALDAAHELGA 302 Query: 289 SLAEELLNNGAREIL 303 ++A LL GA L Sbjct: 303 NVAHLLLKQGASRYL 317 >UniRef50_A3ZKX4 Porphobilinogen deaminase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A3ZKX4_9PLAN Length = 308 Score = 342 bits (878), Expect = 1e-92, Method: Composition-based stats. Identities = 133/308 (43%), Positives = 185/308 (60%), Gaps = 5/308 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LA WQA++V D+L A G VE++ + T+GDV PL +GG+G+F E Sbjct: 4 IRIGTRGSQLAQWQANWVADQLRAV--GTDVEIIHIATQGDVTQG-PLDLIGGRGVFTTE 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 ++ ALL+NR D+AVHS+KD+P E GL L + R D +++ + LP SI+ Sbjct: 61 IQAALLDNRIDVAVHSLKDLPTEAVVGLRLAAVPARGADGDVLITSKASDVLGLPQESII 120 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT S+RR+ QL R D IR +RGN+ TRL KLD+G YDAIILA AGL+RL L RIR Sbjct: 121 GTGSMRRKAQLLHLRRDFQIRDIRGNLDTRLRKLDDGLYDAIILAEAGLRRLELIERIRH 180 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 +P LPAVGQGA+G+E R DS T +LA LNH ++ V AER+M L GGC P Sbjct: 181 VIPKAQMLPAVGQGALGLEIRERDSATAAMLAPLNHEDSHYSVLAERSMLRNLRGGCLAP 240 Query: 246 IGSYAELI--DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 +G++ + ++L +V + DG + G P AE +G +A++L GA ++ Sbjct: 241 VGAWGRIDPIKQLLFLDGVVVSGDGHHKVTASACGPPNRAEDIGRQVADQLAIQGAERLI 300 Query: 304 AEVYNGDA 311 A + Sbjct: 301 AFARATGS 308 >UniRef50_C4ZFT9 Porphobilinogen deaminase n=1 Tax=Eubacterium rectale ATCC 33656 RepID=C4ZFT9_EUBR3 Length = 338 Score = 342 bits (878), Expect = 1e-92, Method: Composition-based stats. Identities = 113/309 (36%), Positives = 160/309 (51%), Gaps = 39/309 (12%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67 I TR S LAL Q YV DKL ++P + V + T GD+ L K+G KG+FVKE+E Sbjct: 5 IGTRGSKLALVQTDYVIDKLKRAYPDDDFKAVIIKTTGDLEQKKALDKIGSKGIFVKEIE 64 Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127 LL + +AVHSMKD+P E GL +REDPRD V N SLD LP G+++GT Sbjct: 65 DELLSGKIHMAVHSMKDMPDEPAAGLTFAKAWKREDPRDVLVLKNAASLDELPHGAVIGT 124 Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE------------------------ 163 S RR+ QL + RPDL + +RGN+ TRL KL +GE Sbjct: 125 GSKRRKYQLLKLRPDLKVVGIRGNIDTRLRKLYDGEIIYEEVADNTVNNNEIANEKKNKY 184 Query: 164 ----YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAAL 219 D I+LA AG+KR+G +S I + +PA QG + +E R D+++ L AL Sbjct: 185 SEYRLDGIVLAAAGIKRIGRDSEITQYFSEDDMIPAPAQGTLALELRADNAKLMAKLDAL 244 Query: 220 NHHETALRVTAERAMNTRLEGGCQVPIGSYAEL-----------IDGEIWLRALVGAPDG 268 + +T L ER ++ G C +P+ +Y ++ + + L A+ G+ DG Sbjct: 245 SDEKTNLCAGIEREFLKQIGGNCHLPVAAYCDIVSEKDRGNDSNKNNRLKLLAMFGSEDG 304 Query: 269 SQIIRGERR 277 Q+ R E+ Sbjct: 305 KQLARTEQV 313 >UniRef50_A5CDH4 Porphobilinogen deaminase n=2 Tax=Orientia tsutsugamushi RepID=HEM3_ORITB Length = 298 Score = 340 bits (874), Expect = 3e-92, Method: Composition-based stats. Identities = 124/295 (42%), Positives = 161/295 (54%), Gaps = 3/295 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 ++R+ +R S LAL QA V K+ GL ++P+ T GD+I + L +GGKGLF+K Sbjct: 2 IIRVGSRASRLALIQAQAVVQKINDL-LGLNAIIIPIKTTGDLIQNKNLYDIGGKGLFLK 60 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E+E ALL N DIAVHS+KDVP P GL L + ER D D VS + + LP G+I Sbjct: 61 EIEYALLNNTIDIAVHSLKDVPAYLPDGLQLAAVLERGDVGDMLVSKIANKITDLPLGAI 120 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE-SRI 183 VGTSS+RR+ QL RPDL I RGNV TR +K+ N E DA +LA AGL+RL + SR Sbjct: 121 VGTSSVRRRIQLLMLRPDLNIVLFRGNVDTRWNKIINNEVDATVLAAAGLQRLNYDTSRF 180 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 +P LPA+GQGA+ IE R DD L A +NH T + ER L C Sbjct: 181 CNIIPQSEMLPAIGQGAIAIEARKDDKLIMPLCAKINHQLTWQLIQVERGYLKTLNADCN 240 Query: 244 VPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 VPIG A I + ++G + E RG Q +G+ A+ Sbjct: 241 VPIGGIASYIGNNSFEAKFMLGDYNMRYFFYSEVRGKLQHGYDIGVEAAKNFQKR 295 >UniRef50_B3DZQ6 Porphobilinogen deaminase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DZQ6_METI4 Length = 298 Score = 339 bits (871), Expect = 7e-92, Method: Composition-based stats. Identities = 114/296 (38%), Positives = 164/296 (55%), Gaps = 3/296 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L I +R S LAL QA + D L +P L +++ + T GD + P+ + +G+F Sbjct: 2 KPLIIGSRGSRLALIQAQLIVDSLKKEYPLLDIQIRVIKTTGDHLEAQPIRDIDQRGIFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE+E LLE D+AVHS+KD+ VE L + I REDPRD ++S + +L AG+ Sbjct: 62 KEIENKLLEGEIDLAVHSLKDLQVELHPRLVIAAIPPREDPRDCWISLQHPHPSSLQAGA 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG-EYDAIILAVAGLKRLGLE-- 180 IV T S RR QL +RPDL I +RGNV +RL KL ++ +LA+AG+KRLG++ Sbjct: 122 IVVTGSPRRANQLLRKRPDLRIVPVRGNVESRLRKLRENRQWQGTVLALAGIKRLGIDIS 181 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 S L + LPA GQGA+ ++ R++D T+ L+ LN TA VTAER L G Sbjct: 182 SFFCTPLSMDWMLPAPGQGALALQARIEDKHTQSLVKHLNDFSTACAVTAERVFLHELGG 241 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 GC+ +G+ AE+ + L + + G+ G AE +G LA+ L N Sbjct: 242 GCRTAVGARAEVEGSRLVLEGIWWPQQAIEPKEGKVVGEIHRAEDLGKKLADLLKN 297 >UniRef50_B8MVK7 Porphobilinogen deaminase, putative n=1 Tax=Talaromyces stipitatus ATCC 10500 RepID=B8MVK7_TALSN Length = 413 Score = 339 bits (871), Expect = 7e-92, Method: Composition-based stats. Identities = 120/337 (35%), Positives = 170/337 (50%), Gaps = 36/337 (10%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGL-VVELVPMVTRGDVILDTPLAKVG----- 57 +R+ +R S +AL Q V L +H G + +GD + + Sbjct: 72 KAVRVGSRNSKMALIQTSSVAAALYKAHHGFFTFPVSTHSVQGDRDKTSAFRDLAKAHGN 131 Query: 58 -------GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS 110 K L+ E+E LL D+ VHS+KDVP P G + R DP DA + Sbjct: 132 KQTAADTAKSLWTLEIEARLLAGDIDLIVHSLKDVPTTLPDGCEIGAFPHRNDPTDALLV 191 Query: 111 N---NYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YD 165 Y SL+ LPAGS+VGT S+RR QL P LII+ RGNV TR++KLD + Y Sbjct: 192 KAGLPYKSLEELPAGSVVGTCSVRRTAQLRHYCPHLIIQECRGNVDTRVAKLDANDSPYT 251 Query: 166 AIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETA 225 AI++A AG+ RL LE RI L AVGQGA+GIE R +D + REL+A ++H T Sbjct: 252 AIVVAAAGIVRLNLEHRITQRLSGPAYTYAVGQGALGIEIRKEDQKARELVACIDHWPTR 311 Query: 226 LRVTAERAMNTRLEGGCQVPIGSYAELI---------------DGEIWLRALVGAPDGSQ 270 +R AERA+ L+GGC PIG ++ + +G ++L + PDG Sbjct: 312 VRCLAERALLRFLQGGCSAPIGVHSAFVRTPAKGEPNVNDNHYEGTLYLTGTLLHPDGGM 371 Query: 271 IIRGERRGAP---QDAEQMGISLAEELLNNGAREILA 304 IR +G D+E +G S+ +++L+ G +IL Sbjct: 372 EIRAHEKGQVKCTADSETIGKSVGKKILDLGGAQILD 408 >UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia (class) RepID=B9L0Q4_THERP Length = 560 Score = 339 bits (870), Expect = 8e-92, Method: Composition-based stats. Identities = 125/295 (42%), Positives = 163/295 (55%), Gaps = 4/295 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + +RI +R S LAL Q V ++L P V +VP+VT GD T L +GG G+ Sbjct: 1 MAARIRIGSRGSTLALAQTEEVVERLRRLVPECSVTVVPIVTTGDRDRATSLTVLGGSGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F KEL ALL D+AVHS KD+P + P GL LV + RED RD V++ L LPA Sbjct: 61 FAKELHEALLAGTIDLAVHSAKDLPTQLPPGLVLVAVLAREDARDVLVTSPPRKLGELPA 120 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ VGTSS RRQ L RPDLI+ +RGNV TRL KL G DA++L AGL+RL Sbjct: 121 GARVGTSSRRRQALLQRARPDLIVVDIRGNVDTRLRKLREGIVDALVLGAAGLRRLSQAD 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + L P+ +PA GQGA+ + R D R ELL+ L+ V ERA G Sbjct: 181 LVAEYLDPDEFVPAPGQGALAVVARESDGRL-ELLSRLDEPLVHEAVAVERAFLAAFGSG 239 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDG---SQIIRGERRGAPQDAEQMGISLAEE 293 C VP+G+YA + + R V PDG SQ + R A + A ++G++LA Sbjct: 240 CSVPLGAYATIAGNRLRFRIAVLLPDGRFISQCLDWPREEAIERARELGLTLATR 294 >UniRef50_Q0BX92 Porphobilinogen deaminase n=1 Tax=Hyphomonas neptunium ATCC 15444 RepID=HEM3_HYPNA Length = 321 Score = 338 bits (869), Expect = 1e-91, Method: Composition-based stats. Identities = 120/298 (40%), Positives = 166/298 (55%), Gaps = 7/298 (2%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPG-LVVELVPMVTRGDVILDTPLAKVGGKGLF 62 LR+ TR SPLAL QAH + D + A+ G E+V T GD + L GGKGLF Sbjct: 11 KRLRLGTRGSPLALAQAHQIADGIRAASAGAYDCEIVAFTTTGDKLTTERLINSGGKGLF 70 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 +EL+ AL D+AVHS+KDVP P G +REDPRD F+S+ S+ LP G Sbjct: 71 TRELDDALSRGELDLAVHSLKDVPSVLPPGQIFAAFPKREDPRDGFLSHGAKSIQDLPEG 130 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 + +GT+SLRR+ Q RPDL + + RGNV TR+ KL+ G DA LA+AGL RLGL Sbjct: 131 ATLGTASLRREAQALALRPDLKVVTFRGNVATRMRKLEEGLADATFLAMAGLTRLGLSEV 190 Query: 183 IRAALPPEISLPAVGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 +P E LPA GQG +G+ R D D+ E+L L+H + + AERA +L+G Sbjct: 191 AT-PIPLEDMLPAAGQGIIGVVTRDDVDTELLEILGQLSHEPSRVAAIAERAFLEKLDGS 249 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQ----MGISLAEELL 295 C+ PI ++ E L V +P G+ RG+ + +G ++A+E++ Sbjct: 250 CRTPIAAHLFDRGDEWQLIGEVLSPGGTTRWRGDGVCRKDATDAQLVLLGRAVAQEII 307 >UniRef50_A2BL26 Probable porphobilinogen deaminase n=2 Tax=Thermoprotei RepID=HEM3_HYPBU Length = 303 Score = 338 bits (869), Expect = 1e-91, Method: Composition-based stats. Identities = 127/299 (42%), Positives = 168/299 (56%), Gaps = 3/299 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LR+ATR S L++ Q + + P L ELV + TRGD+ D P +GGKGLF K Sbjct: 2 KLRVATRGSKLSIAQTMIALEAIKRVEPSLEYELVIVKTRGDIHQDKPFTAIGGKGLFEK 61 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY--DSLDALPAG 122 E+ +A+LE RADIAVHS+KDVP GL L R+ P D V ++ LP+G Sbjct: 62 EVNLAVLEGRADIAVHSLKDVPSAISPGLVLAMTPPRDPPYDVLVVRGGKEKTIWDLPSG 121 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 +IVGTSS RR L R DL+ + LRGNV TRL KL+ G+YDAI+LA AGLKRLG++ Sbjct: 122 AIVGTSSARRVAMLKHVRRDLVFKVLRGNVDTRLRKLEQGQYDAIVLAEAGLKRLGVDIE 181 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 +PP+I PA GQG +G+ S +L + + AERA GGC Sbjct: 182 YWR-IPPDILPPAPGQGIIGVYTLSSRSDILPILEKASDQKAMAEARAERAFLAYAGGGC 240 Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 P+G+YAEL ++ A + +PDGS+ + G P Q+G+ A EL ARE Sbjct: 241 HTPLGAYAELRGNTLYFHAALASPDGSRRVEVRVEGDPDKPTQVGLEAAFELRRLAARE 299 >UniRef50_B5G8F1 Porphobilinogen deaminase n=1 Tax=Streptomyces sp. SPB74 RepID=B5G8F1_9ACTO Length = 314 Score = 336 bits (863), Expect = 5e-91, Method: Composition-based stats. Identities = 128/314 (40%), Positives = 172/314 (54%), Gaps = 13/314 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR SPLAL Q V L P L +E+VP+ T+ D LA++GGKGLFV+E Sbjct: 1 MRIGTRSSPLALAQVEQVSGLLRKFEPDLDIEVVPVTTKADKWQGD-LAQLGGKGLFVRE 59 Query: 66 LEVALLENRADIAVHSMKDVP--VEFPQGLGLVTICEREDPRDAFVSNNY---DSLDALP 120 ++ L + D+AVH MKDVP V P+GL R+D RD + SL LP Sbjct: 60 IDQMLQRGQVDMAVHCMKDVPGDVPMPRGLIFAAYLPRDDVRDVLLVPEGSDVQSLAGLP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD-----NGEYDAIILAVAGLK 175 G+ V TS++RR+ Q+ RPDL + +RG VG+R+ KLD + DA++LA AGL+ Sbjct: 120 PGASVATSAVRRKAQINRVRPDLNVVRVRGLVGSRIDKLDGRKPMDHMLDAMVLARAGLE 179 Query: 176 RLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235 RL L R R LPAVG GA+G+ECR DD LL LN T +TAER M Sbjct: 180 RLDLMHRARQVFEVAEMLPAVGAGALGLECREDDDAVAYLLQQLNDEPTMTEITAERVML 239 Query: 236 TRLEGGCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRG-APQDAEQMGISLAEE 293 L G C PI + DG++ LR +V + DGS+ + G + D +G + E Sbjct: 240 HGLRGHCNSPIAGHCVTDPDGQLSLRGMVFSRDGSKFVHAHFWGESMNDPAVLGSRVCAE 299 Query: 294 LLNNGAREILAEVY 307 LL GAR+I+ + Sbjct: 300 LLRQGARDIIEGIP 313 >UniRef50_A4XK06 Porphobilinogen deaminase n=2 Tax=Clostridia RepID=HEM3_CALS8 Length = 290 Score = 336 bits (863), Expect = 5e-91, Method: Composition-based stats. Identities = 101/293 (34%), Positives = 152/293 (51%), Gaps = 4/293 (1%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 LRI R S L+ Q V K+ G+ E VP+ T+GD+ L G+FV Sbjct: 2 KKLRIGARDSKLSRIQVDIVARKIK-QTLGIECEFVPIKTKGDIDKTKSLKDFKSPGVFV 60 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KE+E+ALL D+AVHS+KD+P E +V + EREDPRD VS + L + Sbjct: 61 KEIELALLSREIDLAVHSLKDLPCEMDSNFEIVAVVEREDPRDVLVSKDGVGFYQLKPNA 120 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +GTSSLRR+ L R D+ + ++RGN+ TRLSK+++ D ++LA A LKRL L+S + Sbjct: 121 KIGTSSLRREVHLKNLRQDIQVVNIRGNIETRLSKIESEGLDGVVLAYAALKRLNLDSHV 180 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 P GQGA+ IEC D + +L+ +N + ++ ER + L GGC Sbjct: 181 SYIFDVNEITPCPGQGAICIECLKDSPY-KNILSKINDADAYIQTQFERLVLKFLGGGCH 239 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 IG + + +I+ A + + G ++I+ G D + L+ L + Sbjct: 240 SSIGVFCKTDQDKIYAFASILS--GDKLIKASIEGDKDDFLSLANKLSNMLKS 290 >UniRef50_C7NFP7 Hydroxymethylbilane synthase n=7 Tax=Actinomycetales RepID=C7NFP7_KYTSD Length = 358 Score = 335 bits (861), Expect = 8e-91, Method: Composition-based stats. Identities = 134/329 (40%), Positives = 180/329 (54%), Gaps = 33/329 (10%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 V+R+ TR+S LA Q+ +V D L A G VELV + T GDV PL+++GG G+FV Sbjct: 14 RVVRLGTRRSDLATTQSTHVADALRAR--GHEVELVLVTTEGDVNR-APLSRIGGTGVFV 70 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 L ALL DIAVHS+KD+PV PQ L + + EREDPRDA V+ + +L+ LPAG+ Sbjct: 71 SALRDALLAGEIDIAVHSLKDLPVAQPQELVIAAVPEREDPRDALVARDGLTLETLPAGA 130 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 VGT S RR+ QL RPDL + LRGNV RL+ + GE DA++LA AGL+RLGL + Sbjct: 131 RVGTGSPRREAQLRVARPDLEVVDLRGNVPRRLATVAEGELDAVVLAGAGLRRLGLTEHV 190 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 L P++ +PA GQGA+ +ECR DD+ + +L L+H T TAERA+ LE GC Sbjct: 191 TQWLEPQVMVPAPGQGALAVECRSDDAESIAMLEPLDHLPTRTATTAERAVLGTLEAGCS 250 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQII------------------------------R 273 PIG+ A + L G DGS+ + Sbjct: 251 APIGALARHDGARVDLMTFAGPRDGSRALLEADCARGVPAGHPADTPDDTPADTPDDSRN 310 Query: 274 GERRGAPQDAEQMGISLAEELLNNGAREI 302 +R A ++G +AE L GA + Sbjct: 311 DDRVALDTAARELGRRVAEALRGGGADVL 339 >UniRef50_Q09899 Porphobilinogen deaminase n=2 Tax=Schizosaccharomyces RepID=HEM3_SCHPO Length = 336 Score = 335 bits (861), Expect = 8e-91, Method: Composition-based stats. Identities = 126/314 (40%), Positives = 176/314 (56%), Gaps = 16/314 (5%) Query: 8 IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG---GKGLFVK 64 I TR+S LA+ Q+ ++++L +P L ++ T GD IL L + K L+ + Sbjct: 9 IGTRKSKLAVIQSEIIREELEKHYPHLEFPIISRDTIGDEILSKALFEFKRQLAKSLWTR 68 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALPA 121 ELE L+ N+ I VHS+KD+P E P G+ + I +R P DA V +Y ++ LP Sbjct: 69 ELEALLVTNQCRILVHSLKDLPSEMPDGMVIACIPKRSCPLDAIVFKAGSHYKTVADLPP 128 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAGLKRLGL 179 GS+VGTSS+RR+ LA P L +RGNVGTRL+KLD + +D ++LA AGL RLGL Sbjct: 129 GSVVGTSSIRRRALLARNFPHLRFVDIRGNVGTRLAKLDAPDSQFDCLVLAAAGLFRLGL 188 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 + RI L AVGQGA+ +E R DD E+L L H ET AERA+ RL+ Sbjct: 189 KDRIAQMLTAPFVYYAVGQGALAVEVRADDKEMIEMLKPLQHQETLYACLAERALMKRLQ 248 Query: 240 GGCQVPIGSYAEL-----IDGEIWLRALVGAPDGSQIIRGE---RRGAPQDAEQMGISLA 291 GGC +PIG ++ I L V + DG + G + ++AE++GI++A Sbjct: 249 GGCAIPIGVQTDVLAISNSSYRISLLGTVLSADGLRAAFGNAEAVVSSEEEAEELGITVA 308 Query: 292 EELLNNGAREILAE 305 LL NGA IL E Sbjct: 309 LALLKNGAGPILEE 322 >UniRef50_C8WIZ2 Porphobilinogen deaminase n=2 Tax=Coriobacteriaceae RepID=C8WIZ2_EGGLE Length = 327 Score = 334 bits (857), Expect = 3e-90, Method: Composition-based stats. Identities = 137/318 (43%), Positives = 183/318 (57%), Gaps = 13/318 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LALWQAH+V D L A+ PG+ V + + T+GD IL L+K+G KGLF KE Sbjct: 4 MRIGTRGSKLALWQAHHVADLLRAASPGMDVSVEVVKTKGDRILGVALSKIGDKGLFTKE 63 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE AL + R D+ VHSMKDVP P+GL L R D RD V+ + + LPAGS V Sbjct: 64 LEQALFDGRVDVCVHSMKDVPTALPEGLALAGCLIRADARDVLVAASGTTFAGLPAGSRV 123 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT +LRR QL R DL +RGN+ TR++K+ +G DA++LA AG++R+G + + Sbjct: 124 GTGALRRLSQLRAVRDDLDYVEVRGNLDTRIAKVRDGALDAVVLAAAGIERMGWSAEVAE 183 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 A + +PAVGQGA+G+E R DD RT A + T V AER + L+GGCQVP Sbjct: 184 AFSVDTVVPAVGQGAIGLEVRADDERTARACAQVRCAATDACVAAERHVMRALDGGCQVP 243 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGE-------------RRGAPQDAEQMGISLAE 292 IG+YA +G + L A VG+ DGS ++R A ++A + E Sbjct: 244 IGAYARYEEGLLVLDAFVGSLDGSHVLRSRLSAASQPPNDTDAVEAAVREARALAQRAVE 303 Query: 293 ELLNNGAREILAEVYNGD 310 E GAR +L V Sbjct: 304 EFEAQGARAVLDAVRAAG 321 >UniRef50_A8SQW4 Putative uncharacterized protein n=1 Tax=Coprococcus eutactus ATCC 27759 RepID=A8SQW4_9FIRM Length = 350 Score = 334 bits (857), Expect = 3e-90, Method: Composition-based stats. Identities = 115/314 (36%), Positives = 164/314 (52%), Gaps = 26/314 (8%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 +++ TR S LAL Q V L P + ++V M TRGD L + GGK +F Sbjct: 39 KKTVKVGTRGSKLALAQTELVIKALNERFPQIDFQMVTMSTRGDRDTSRALLEFGGKAVF 98 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 V+E E A+L+ DIAVHS KD+P+E +GL + R P+D F+ + S D Sbjct: 99 VEEFEEAILKGDIDIAVHSAKDMPMEIMEGLTISGTLPRACPQDVFIYKSGRSFDR-NDS 157 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL--- 179 +VGTSSLRRQ Q+ + P+ + ++LRGNVGTR+ KL++GEYDAIILA AGL+RLG+ Sbjct: 158 FVVGTSSLRRQYQIRDMYPNAVCKNLRGNVGTRIQKLEDGEYDAIILAAAGLERLGVIED 217 Query: 180 -------------ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETAL 226 + L E LPA QG + IE R +++ A+N E Sbjct: 218 KGNDSTECFEVHKDELTFRYLSTESMLPAACQGIIAIETRTSGEAY-DMVRAINDTEAYT 276 Query: 227 RVTAERAMNTRLEGGCQVPIGSYAELIDGEIWL---RALVGAPDGSQ-----IIRGERRG 278 ++T ERA+ +RL GC PIG Y+EL + L + + D + I R G Sbjct: 277 QLTCERAVLSRLNAGCHEPIGVYSELKGKHMKLSLMKVDAASSDKEKDEEIQIHRKTVEG 336 Query: 279 APQDAEQMGISLAE 292 + EQ+ +L + Sbjct: 337 NTSEWEQLVEALIK 350 >UniRef50_A8MGE4 Porphobilinogen deaminase n=30 Tax=cellular organisms RepID=HEM3_ALKOO Length = 296 Score = 333 bits (856), Expect = 4e-90, Method: Composition-based stats. Identities = 113/293 (38%), Positives = 160/293 (54%), Gaps = 5/293 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +R+ +R+S LA+ Q+ V + + P + +ELV M T GD+ LD L K+GGKGLF+K Sbjct: 2 KIRVGSRESKLAVKQSEIVIEAIRKYDPNIEIELVTMKTTGDIKLDQTLDKIGGKGLFIK 61 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 EL+ AL ++R DI VHS KD+P+ + L +V + +REDPRD V ++ Sbjct: 62 ELDQALYDDRVDITVHSFKDMPMAIDEYLPIVAVSKREDPRDVLVLPK--TVKEPDFSKP 119 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +G SS RR+ QL E P + +RGNV TRL KLD GE+ AI LA+AGLKRLGLE RI Sbjct: 120 IGCSSFRRKIQLQEIYPHCSVEPIRGNVLTRLEKLDRGEFSAITLALAGLKRLGLEERIS 179 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 LPA QG + ++ R L+ + E AER+ L GGC Sbjct: 180 RIFEVTEILPAACQGVIVVQARKG--FDVSFLSDFHDKEAWDISMAERSFVRTLNGGCSS 237 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 P+ +Y E+ D + L L S + + GA + E+MG +LA ++ Sbjct: 238 PVAAYGEIKDNYLTLTGLYVDSSNS-VHKKTITGARKQGEEMGFNLALQMKGE 289 >UniRef50_B9XN63 Porphobilinogen deaminase n=1 Tax=bacterium Ellin514 RepID=B9XN63_9BACT Length = 332 Score = 332 bits (853), Expect = 7e-90, Method: Composition-based stats. Identities = 127/329 (38%), Positives = 172/329 (52%), Gaps = 38/329 (11%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG---K 59 + + IATR S LAL QA+ V + ++ P L +EL + T GD + LAK G K Sbjct: 6 NKPIFIATRGSALALAQANAVLSQCRSAFPKLDIELKIIKTTGDKLQKASLAKEGESLPK 65 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSL--- 116 GLF KELEVALL ADIAVHS+KD+P E P GL L + +R D RD V + + L Sbjct: 66 GLFTKELEVALLNGDADIAVHSLKDLPTELPTGLILGAVSKRADVRDVLVYRDAEYLRSQ 125 Query: 117 ---------------DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN 161 P G+ V TSS RR+ QL +R DL + +RGNV TRL KL N Sbjct: 126 PGKSNRRGFTPKLAIKDFPPGATVATSSTRRKAQLLAQRGDLNVVEIRGNVATRLEKLAN 185 Query: 162 -GEYDAIILAVAGLKRLGL--------------ESRIRAALPPEISLPAVGQGAVGIECR 206 E DA +LA AGL+RL E + L ++ LP VGQ A+G+E R Sbjct: 186 QPELDATVLAAAGLERLNFKITAEGKLAGEGIPEGLLATILDFDVMLPCVGQAALGMEIR 245 Query: 207 LDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAP 266 +D+R +E+ LNH ET V AER+ + + GGCQ P+ +YAE+ ++ +RA Sbjct: 246 ENDARIQEICDRLNHPETHACVLAERSFLSGMGGGCQSPVAAYAEIAGDQLQMRAASFRE 305 Query: 267 DGSQIIRGERRGAPQDAEQMGISLAEELL 295 + R + +A +G LA +L Sbjct: 306 --TSARRAVGGKSINEAVALGQELAAKLK 332 >UniRef50_A4QB59 Porphobilinogen deaminase n=15 Tax=Corynebacterium RepID=HEM3_CORGB Length = 302 Score = 332 bits (853), Expect = 9e-90, Method: Composition-based stats. Identities = 118/304 (38%), Positives = 171/304 (56%), Gaps = 8/304 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 L+I TR S LA QA ++D+L + G EL + T GDV + +P+ ++G G+F + Sbjct: 2 TLKIGTRGSKLATTQAGTIRDQLK--YFGRDAELHIVTTPGDVNM-SPVERIG-VGVFTQ 57 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L L D+AVHSMKD+P LV + R D R+A ++ + +L LP G+ Sbjct: 58 ALRDVLHAGECDVAVHSMKDLPTAADPRFHLV-VPTRADSREALIARDGLTLAELPEGAK 116 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGTS+ RR QL RPDL I LRGN+ TR+ K+ +GE DA++LA AGL R+G++ R Sbjct: 117 VGTSAPRRISQLKAIRPDLEILPLRGNIDTRMGKVTSGELDAVMLAYAGLTRVGMQDRAT 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 +I +PA QGA+ IECR DD+ T L L H +T + AER + RLE GC Sbjct: 177 EVFDADIIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVLNRLEAGCTA 236 Query: 245 PIGSYAELI---DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 P+ ++A L + L A V A DGS + G E++G +A++L++ GA Sbjct: 237 PVAAHATLDGYSGDTMTLTAGVYALDGSDQLVFSAEGDGARPEELGELVAQQLIDAGAAN 296 Query: 302 ILAE 305 +L + Sbjct: 297 LLGD 300 >UniRef50_Q82P95 Porphobilinogen deaminase 2 n=14 Tax=Actinomycetales RepID=HEM32_STRAW Length = 314 Score = 332 bits (852), Expect = 1e-89, Method: Composition-based stats. Identities = 124/305 (40%), Positives = 167/305 (54%), Gaps = 4/305 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI +R SP+AL Q V+ +L A HP E+V + T GD + L+KV GKG F KE Sbjct: 10 IRIVSRDSPMALAQVARVRAELAALHPRTRTEVVAVKTTGDKWMGD-LSKVDGKGAFTKE 68 Query: 66 LEVALLENRADIAVHSMKDVPV--EFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 ++ ALL AD+AVH +KDVP P G +R+D RDA V +LD LP G+ Sbjct: 69 VDAALLAGEADLAVHCVKDVPADRPLPAGTMFAAFLKRDDIRDALVHPGGLTLDELPPGT 128 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +GTSS+RR QLA P L RGN RL KL GE DA++LAV+GL+R+G E I Sbjct: 129 RIGTSSVRRVAQLAAAYPHLECVPFRGNANRRLEKLAAGEADALLLAVSGLERIGREDVI 188 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 L PE +P +G G + ++CR D+ E ++ L T TAER L+G C Sbjct: 189 TEVLEPETMMPPIGAGILALQCREGDTGLIETISELGDPGTHREATAERMFLHVLQGHCN 248 Query: 244 VPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 PI YA +GE+ LRA V DG ++ D +G S+A LL GARE+ Sbjct: 249 SPIAGYARTERNGELSLRASVFTLDGKTVLNAHEWAGRLDPATLGTSVAVALLRQGAREL 308 Query: 303 LAEVY 307 + ++ Sbjct: 309 IDDIP 313 >UniRef50_C1F251 Hydroxymethylbilane synthase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F251_ACIC5 Length = 312 Score = 332 bits (851), Expect = 1e-89, Method: Composition-based stats. Identities = 139/322 (43%), Positives = 176/322 (54%), Gaps = 37/322 (11%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLA----KVGGKGL 61 +RI +R S LALWQA+++ +L G V + + T GD + A ++GGKG+ Sbjct: 2 MRIGSRGSQLALWQANHIAARLRTL--GHEVTIEIIRTTGDALQHVTFAKVSTELGGKGI 59 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F KE+E AL E R D+AVHS+KD+P + L I ER DPRDA +S Y SL +LP Sbjct: 60 FTKEIEEALREGRIDLAVHSLKDLPTDLDPAFTLAAIPERVDPRDALLSARYTSLASLPH 119 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ VGTSS RR+ QL R DL + RGNV TR+ K+ G+ DAIILA AGL+RLGL Sbjct: 120 GACVGTSSERRRAQLLVHRSDLRFQEFRGNVDTRIRKMVEGQADAIILASAGLERLGLTE 179 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 R L PEI PA GQGA+ IE R DD+ T +LA+L+H T VTAER L GG Sbjct: 180 YRRECLAPEILCPAAGQGALAIETRADDAETLAILASLDHSATRYAVTAERTALASLGGG 239 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ-------------------- 281 CQVPIG + A V DG+ I+G GA Sbjct: 240 CQVPIGIHC----------APVPGADGAYAIQGVVAGAAAKAASSAAHPVIRVAFEHQQG 289 Query: 282 -DAEQMGISLAEELLNNGAREI 302 + +G LAEELL GA+ Sbjct: 290 LSPQALGRQLAEELLRQGAQPF 311 >UniRef50_Q8TXC8 Probable porphobilinogen deaminase n=1 Tax=Methanopyrus kandleri RepID=HEM3_METKA Length = 298 Score = 332 bits (851), Expect = 1e-89, Method: Composition-based stats. Identities = 120/299 (40%), Positives = 172/299 (57%), Gaps = 3/299 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHP-GLVVELVPMVTRGDVILDTPLAKVGGKG 60 + +R+ATR S LA+ Q V + L P + VE+V +RGDV+ D PL K+G KG Sbjct: 1 MSETIRVATRSSRLAIIQTREVIELLERESPRDVEVEIVKTKSRGDVVRDRPLHKLGEKG 60 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 +FVKE++ +LE +ADIAVHS KDVP + + + R DPR+ VS + L LP Sbjct: 61 VFVKEVDRLVLEGKADIAVHSAKDVPSVVDYPVDVAAVPPRRDPRECLVSRHGG-LKELP 119 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGTSS RR+ Q+ RPDL + +RGNV TR+SK+ EYDA +LA GL RLG+ Sbjct: 120 RGATVGTSSPRRRAQILLERPDLKVEPMRGNVDTRVSKVRRREYDAAVLAKVGLDRLGMT 179 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 S + PE +P GQGA+ I CR DD R + LL ++ ++ + V E+A+ L Sbjct: 180 SEVSEVYDPEEFVPPAGQGALMITCRKDDDRVKRLLEVVDDEKSRVEVETEKAVVRELGV 239 Query: 241 GCQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GC P+G + + L + DGS + RG+P+D + +S A E+L++G Sbjct: 240 GCSEPVGVHVRARDGDHVRLVLGLFEEDGSCGHVLKMRGSPEDVVREAVSQAREVLSDG 298 >UniRef50_A0DD68 Chromosome undetermined scaffold_46, whole genome shotgun sequence n=2 Tax=Paramecium tetraurelia RepID=A0DD68_PARTE Length = 306 Score = 331 bits (850), Expect = 2e-89, Method: Composition-based stats. Identities = 124/312 (39%), Positives = 171/312 (54%), Gaps = 13/312 (4%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTR-GDVILDTPLAKVGGKG 60 + LRIATR S LA+ Q +YV +L E++ + GDV L PL ++ G Sbjct: 1 MQRQLRIATRSSALAMAQTNYVISELKQ-----ECEIIKVSNEVGDVNLQDPLYQMPTVG 55 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLD 117 +F K++E LLE +AD+AVHS+KD+P L L + E D + N Y SL Sbjct: 56 VFTKQVEQYLLEQKADVAVHSLKDLPTIIDAQLHLAAYTKFEQRGDVVLLNKKYNYKSLS 115 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177 LP G VGTSSLRR + R P L + ++RGN+ TR+ KLD G+YDAIILA AG+ RL Sbjct: 116 ELPDGLKVGTSSLRRIATIRSRYPKLNLINIRGNLNTRIQKLDEGQYDAIILAKAGILRL 175 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 GL +I L + L A Q A+GI+CR DD T L LN + R AER Sbjct: 176 GLAEKISFDLDEKEFLYAPAQAALGIQCRKDDLETIGRLQILNDTDAQKRCVAERMFLNL 235 Query: 238 LEGGCQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 LEGGC++PI Y+E DG+++++ V A DGS++I E E +G L E++ Sbjct: 236 LEGGCRLPIAVYSECREDGQVYIKGRVLAVDGSKVIEDEA---LDHFEIVGQILCEKIKV 292 Query: 297 NGAREILAEVYN 308 G E++ + Sbjct: 293 LGGVELIESLKQ 304 >UniRef50_B8GXG1 Porphobilinogen deaminase n=8 Tax=Caulobacteraceae RepID=HEM3_CAUCN Length = 322 Score = 331 bits (850), Expect = 2e-89, Method: Composition-based stats. Identities = 132/315 (41%), Positives = 176/315 (55%), Gaps = 17/315 (5%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMAS----------HPGLVVELVPMVTRGDVILDTPLA 54 +RI R S L+L Q+ ++ ++ + L+P+VT GD I D L Sbjct: 6 PIRIGARGSKLSLAQSGLMQARIAHALGVPAGASKDEIEAAAPLIPIVTSGDRIQDRRLM 65 Query: 55 KVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD 114 ++GGKGLF KE+E ALL+ R D AVHS+KD+P E P GL L EREDPRDAF+S+ + Sbjct: 66 EIGGKGLFTKEIEEALLDGRIDCAVHSLKDMPAELPPGLVLAATPEREDPRDAFISHVCE 125 Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174 L+ LP G+ +GT+SLRRQ Q RPDL I LRGNV TRL+KL+ GE DAI+LA +GL Sbjct: 126 RLEDLPKGARLGTASLRRQAQALHVRPDLEIVMLRGNVDTRLAKLERGEADAILLAQSGL 185 Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234 RLGL R+ L P+ PA GQGA+ IE R +D L A+ +T + V AER Sbjct: 186 NRLGLGHLTRSWLDPDACPPAPGQGALVIETRAEDIG-APWLEAVRCRQTTIAVAAERGA 244 Query: 235 NTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGA------PQDAEQMGI 288 LEG C+ IG+ A L + + PDG+Q R E +A G+ Sbjct: 245 LLALEGSCRTAIGARAILDGARLSMIVEALTPDGAQRFRREGDITLTGADDIAEARAFGL 304 Query: 289 SLAEELLNNGAREIL 303 +L E+ G I+ Sbjct: 305 TLGAEVRAAGGDAII 319 >UniRef50_B0D5Q2 Predicted protein n=1 Tax=Laccaria bicolor S238N-H82 RepID=B0D5Q2_LACBS Length = 340 Score = 331 bits (850), Expect = 2e-89, Method: Composition-based stats. Identities = 118/316 (37%), Positives = 172/316 (54%), Gaps = 10/316 (3%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 + I R S LA QA V+ +L P E+ I + + + GG L+ Sbjct: 16 QKAIVIGCRPSTLAKIQAELVRSRLKVLFPASRFEISSKKFPQPEIGTSQITERGGASLW 75 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLDAL 119 ELE AL + DI VHS+KDVP + +G ++ + ERED RD V + +L+ L Sbjct: 76 TTELEDALFDGDIDILVHSLKDVPTKLKEGCEIIHVLEREDRRDCLVVKDGLPYRTLEEL 135 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAGLKRL 177 PAGS+VGT S+RR Q+ R P L+I+ +RGN+ TRL KLD+ + Y A+ILA AGL RL Sbjct: 136 PAGSVVGTGSVRRVAQMKRRYPLLVIKDVRGNIDTRLQKLDSPDLPYTALILASAGLLRL 195 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 L RI + L P IS PAVGQG +G E R D++ + +++ L + V AERA+ Sbjct: 196 SLHDRITSYLSPPISYPAVGQGCLGAEFRSADTKVKAMVSRLEVWQDGWAVRAERALLWV 255 Query: 238 LEGGCQVPIGSYAELIDGEI--WLRALVGAPDGSQIIRGERRG---APQDAEQMGISLAE 292 LEGGC P+G ++ I +++ +PDGS+ I E G + ++ ++G A Sbjct: 256 LEGGCAFPVGIWSSWSGDNIASESLSVMTSPDGSEEITVETTGVVASVEEVLELGKQAAR 315 Query: 293 ELLNNGAREILAEVYN 308 LL G R I+ ++ Sbjct: 316 SLLEKGGRGIIVDLRA 331 >UniRef50_D0J8N1 Porphobilinogen deaminase n=2 Tax=Blattabacterium RepID=D0J8N1_BLASP Length = 310 Score = 331 bits (849), Expect = 2e-89, Method: Composition-based stats. Identities = 99/312 (31%), Positives = 153/312 (49%), Gaps = 7/312 (2%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 ++ ++RI TR SPLA+ QA V+ L G L + + GD+I + PL K G+ Sbjct: 1 MNKIIRIGTRNSPLAISQAIEVQKVLHRL--GYCSHLFFIKSEGDLIQNIPLYKFKKVGI 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS-LDALP 120 F + L LL + D+AVHS+KDVP P+ + L +R D + + L Sbjct: 59 FTRNLTDVLLSGKIDMAVHSLKDVPTSLPEKIVLSAYLKRGSFSDLLIYQGSSNFLLNSK 118 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 +++ T SLRR+ R P I LRGN+ TRL KL N + I A GL+RLGL Sbjct: 119 IEAVIATGSLRRRAFWKNRYPHHTIVDLRGNINTRLKKLYNNSWKGAIFAKVGLERLGLL 178 Query: 181 SRIRAALP--PEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 + + + +P+ GQG + + R D+ L L+ T L ER L Sbjct: 179 NDLEGFNFKVLDWMIPSPGQGIIVVSTRKDNEWIHYLTKELDDRNTRLSANIERQFLKTL 238 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 GGC PIG++A + + I+ ++ + DG Q IR ++ G + +G A+E+L G Sbjct: 239 GGGCVTPIGAHAIIKNKIIYFTGILFSLDGMQKIRKKKIGT--NYNVIGYQCAKEILEEG 296 Query: 299 AREILAEVYNGD 310 ++IL + + Sbjct: 297 GKKILENMRIKN 308 >UniRef50_C6XKH7 Porphobilinogen deaminase n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XKH7_HIRBI Length = 323 Score = 330 bits (848), Expect = 3e-89, Method: Composition-based stats. Identities = 110/299 (36%), Positives = 152/299 (50%), Gaps = 7/299 (2%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPG-LVVELVPMVTRGDVILDTPLAKVGGKG 60 +++I R SPLA+ QA + + +E+ T GD +LD L GGKG Sbjct: 17 STQIVKIGARGSPLAVQQAEDFAARFKEIVGNTVEIEIHTFTTSGDQLLDKRLQDAGGKG 76 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF +EL++A L R DI VHS+KDVP P GL + REDPRDA ++ LP Sbjct: 77 LFTRELDIAQLSGRIDIVVHSLKDVPTVLPDGLQMGCYLPREDPRDALFGKVG-NIKDLP 135 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ +GT+SLRR Q RPDL I RGNV TRL KL+ G+ DA +LA AGL RLG+ Sbjct: 136 HGATLGTASLRRSAQALALRPDLKIVMFRGNVQTRLRKLEEGQADATLLAAAGLNRLGMT 195 Query: 181 SRIRAALPPEISLPAVGQGAVGIE-CRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 + +P E LPA GQG V + + ++ E+ + AERA RL+ Sbjct: 196 DKAAGFMPKEEMLPACGQGIVCTTLTNNAEDWIFKACLQIDVLESRIAAIAERAFLKRLD 255 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRG----APQDAEQMGISLAEEL 294 G C+ PI + + + +R V A DGS+ + A +G L E++ Sbjct: 256 GSCRTPIAGHLSFNETGVDMRGEVLADDGSKRWFSQMSLDTIPDENQAASLGFELGEKV 314 >UniRef50_B6W7F3 Putative uncharacterized protein n=1 Tax=Anaerococcus hydrogenalis DSM 7454 RepID=B6W7F3_9FIRM Length = 318 Score = 330 bits (846), Expect = 5e-89, Method: Composition-based stats. Identities = 103/309 (33%), Positives = 155/309 (50%), Gaps = 12/309 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 ++I +R S LAL QA+ VKD L GL ++V + T+GD I D + ++ KG+FV+E Sbjct: 2 IKIGSRASKLALIQANMVKDILEKE--GLEAQIVEISTKGDRIRDRKIDQLNSKGVFVRE 59 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALPAGSI 124 +E LL+ DIAVHS+KD+P + L + EDPRD FV + + +D L ++ Sbjct: 60 IEEKLLDKTIDIAVHSLKDMPSQIDDRLIFTPPLKGEDPRDCFVGKDVFKKMDDL-NNAL 118 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGT S RR CQ ++ +++RGNV TR+ K+ + D +ILA +GL R GL+ I Sbjct: 119 VGTGSNRRVCQGKNHFSNIKFKAIRGNVETRIKKVQSENLDGVILAKSGLIRAGLDGEIN 178 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L P I P+ QG +GIE R +D + E+ + +T R+ ERA L C Sbjct: 179 FDLDPHIFTPSPCQGILGIEIRKEDKKLFEIFKKNSDEKTLFRMETERAFQKELGADCST 238 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 P+G + E+ +I L + +I G + + LA L Sbjct: 239 PMGIFTEIDHDKITLTGSMAFDKDDRINYERVSGNISERIHLAQKLARTLKKK------- 291 Query: 305 EVYNGDAPA 313 Y + P Sbjct: 292 -SYKKNNPC 299 >UniRef50_Q7UPN0 Porphobilinogen deaminase n=1 Tax=Rhodopirellula baltica RepID=HEM3_RHOBA Length = 337 Score = 330 bits (846), Expect = 5e-89, Method: Composition-based stats. Identities = 127/332 (38%), Positives = 182/332 (54%), Gaps = 27/332 (8%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 LRIATR+SPLA+WQA +V L G E+VP+V++GD + P+ GLF Sbjct: 9 TTRLRIATRESPLAMWQAEHVAKLLKKH--GFQTEIVPLVSKGDTDM-RPIDGTRQVGLF 65 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS------- 115 K ++ AL+++ AD+AVHS+KD+P E L + RE DA V + Sbjct: 66 TKRIQQALVDDEADVAVHSLKDLPTEPDSRFVLAAVPPRESVLDALVFADNSPHLESQTG 125 Query: 116 ----LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAV 171 LD LP G+ VGT S RR QL + RPDL + +RGNV TRL+KL+ GE+DAI+LA Sbjct: 126 AESPLDYLPQGARVGTGSTRRLAQLKQLRPDLEVLPIRGNVQTRLAKLNAGEFDAIVLAH 185 Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231 AG+ RL + P + +PA GQGA+GIE R DD+ + +A LN L TAE Sbjct: 186 AGILRLEMTDLPHRLFPLDEMIPAPGQGALGIEVRSDDAGAMDAIANLNDAAARLAATAE 245 Query: 232 RAMNTRLEGGCQVPIGSYAELI----DGEIWLRALVGAPDGSQIIRGERRGA-------- 279 R + + L GGC PI +A+L E+ LRA+V + DG Q ++ + R Sbjct: 246 RKVLSELHGGCLAPIACHAKLETSNHGTELCLRAIVMSADGEQRLQEDARITVQPNDADL 305 Query: 280 -PQDAEQMGISLAEELLNNGAREILAEVYNGD 310 +A ++G +A+ L + GA ++++ V Sbjct: 306 HVAEAHELGTLVAKRLRDKGADKLISTVRENH 337 >UniRef50_B2IAW6 Porphobilinogen deaminase n=4 Tax=Alphaproteobacteria RepID=B2IAW6_BEII9 Length = 337 Score = 328 bits (842), Expect = 1e-88, Method: Composition-based stats. Identities = 138/306 (45%), Positives = 179/306 (58%), Gaps = 5/306 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 LR+ TR SPLAL QAH + D+L +H V + + T GD+I D PL+ GGKGLF Sbjct: 19 LRLGTRGSPLALAQAHELADRLARAHGFAKEAVAITIIRTSGDMIQDRPLSLAGGKGLFT 78 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KEL+ AL+E D+AVHS KD+P P+ L + RED RD ++S LP GS Sbjct: 79 KELDQALIEGMVDLAVHSAKDLPTILPEDLIIAGYLPREDVRDVWISPKAGHPRDLPPGS 138 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +VGT+SLRR L RPDL +R LRGNV TRL+KL GE DA +LA+AGL+RLGL + Sbjct: 139 VVGTASLRRGALLKRLRPDLEVRLLRGNVETRLAKLAAGEVDATLLALAGLRRLGLADKA 198 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 L E LPA GQGA+GI R DD+ T LLA + T + + AER T L+G C+ Sbjct: 199 TQVLAIEDFLPAAGQGAIGITTRRDDAATLALLAPILDPATHVALAAERGFLTVLDGSCK 258 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 PIG++A + ++ LR +V PDGS+ G + + A EL AR IL Sbjct: 259 TPIGAHATVEHDQVTLRGIVLRPDGSEWFEACESGPLESGS---LEAARELGETAARAIL 315 Query: 304 AEVYNG 309 A + G Sbjct: 316 ARLPEG 321 >UniRef50_Q46CH0 Probable porphobilinogen deaminase n=7 Tax=Euryarchaeota RepID=HEM3_METBF Length = 316 Score = 328 bits (842), Expect = 2e-88, Method: Composition-based stats. Identities = 113/304 (37%), Positives = 164/304 (53%), Gaps = 7/304 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG-GKGLFVK 64 + I TR S LAL QA V L A G+ L + T GD D PL V G G FV+ Sbjct: 1 MIIGTRGSQLALAQAETVARLLKAK--GVETSLKIIKTSGDRFTDRPLHAVSSGVGAFVR 58 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 EL+ +LE + DIAVHSMKD+P P L V + +R+ P D ++ + LD L SI Sbjct: 59 ELDEVMLEGKIDIAVHSMKDMPTIRPPTLPTVAVLKRDTPFDLLLTYDGTPLDELSEQSI 118 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSSLRR Q+ RPDL+ + LRGN+ TRL KL G+YD I+LA AGL+R+G E Sbjct: 119 IGTSSLRRAAQIKRYRPDLVTQDLRGNIDTRLRKLKEGKYDGILLAKAGLERMGWELE-G 177 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L P+ P+ QG + + R + + ++ L+H ++ + ER + + L GGC Sbjct: 178 EILSPDFFCPSPNQGTIAVVTRAE-TEAEAAVSRLDHTDSRIATEIERILISELGGGCTT 236 Query: 245 PIGSYAELIDG--EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302 PIGSYAE++ ++ +RA V + DG + + + L L++ G +++ Sbjct: 237 PIGSYAEIMPDRKKLHVRAEVLSLDGEETVGINEFIPMAGGIEKARELGSSLVHMGGKKL 296 Query: 303 LAEV 306 E Sbjct: 297 ADEA 300 >UniRef50_C4QMG7 Hydroxymethylbilane synthase (Porphobilinogen deaminase, putative) n=1 Tax=Schistosoma mansoni RepID=C4QMG7_SCHMA Length = 411 Score = 327 bits (839), Expect = 3e-88, Method: Composition-based stats. Identities = 117/302 (38%), Positives = 160/302 (52%), Gaps = 25/302 (8%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 NV+R+ +R+S LAL Q + L +P ++ E+V M T GD ILD L+K+G K LF Sbjct: 8 NVVRVGSRRSNLALLQTGMAVNLLQKQNPHILFEVVEMATVGDKILDVSLSKIGDKSLFT 67 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS---NNYDSLDALP 120 KELE ALL D+ VHS+KDVP P GL L + R P D + L LP Sbjct: 68 KELENALLSGEVDLVVHSLKDVPSTLPSGLVLGCVFARVSPEDVVLMAPHYRGRKLSDLP 127 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--------------NGEYDA 166 GS VGTS++RR L + P L S+RGN+ TRL+KLD + YDA Sbjct: 128 IGSTVGTSAVRRVATLTRKYPHLKFVSIRGNLNTRLAKLDTPPASKDNCCSGNPSPSYDA 187 Query: 167 IILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETAL 226 IILA AG++R+G RI L + AV QGA+ ECRL D+ +LL+ ++ AL Sbjct: 188 IILAKAGVERMGWSHRIDQVL-TDSF-YAVSQGALACECRLVDNFIMDLLSHIHDESAAL 245 Query: 227 RVTAERAMNTRLEGGCQVPIGSYA--ELIDG----EIWLRALVGAPDGSQIIRGERRGAP 280 AER++ +L+GGC +PIG + L ++ L A + + DG + I Sbjct: 246 TTIAERSLMRQLDGGCSIPIGVRSDLVLKGDLNYYQLTLHANILSVDGGKSIERSASVVF 305 Query: 281 QD 282 D Sbjct: 306 PD 307 >UniRef50_C5RMN3 Porphobilinogen deaminase n=1 Tax=Clostridium cellulovorans 743B RepID=C5RMN3_CLOCL Length = 300 Score = 327 bits (838), Expect = 4e-88, Method: Composition-based stats. Identities = 113/301 (37%), Positives = 168/301 (55%), Gaps = 8/301 (2%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + ++RI TR+S LAL Q + V D + HP + E+V M T+GD ILD L GGKG Sbjct: 1 MKKIIRIGTRKSKLALMQTNIVIDAIKKKHPEINCEVVEMSTKGDEILDKSLLSFGGKGA 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS-NNYDSLDAL- 119 FV E E A+ D+AVHS KD+P++ GL +V + +REDPRD V+ NN D+++ Sbjct: 61 FVSEFEKAIKSGEIDLAVHSAKDMPMDLLTGLKIVAVTKREDPRDVLVTANNKDTINDFN 120 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 ++GT+SLRR+ Q+ ++ + LRGNV RL KL +GEYD IILA AGLKRLGL Sbjct: 121 KTNKLIGTTSLRRKLQIKRLLNNVDTKDLRGNVQRRLEKLISGEYDGIILAAAGLKRLGL 180 Query: 180 ESRIR---AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236 R L E +PA GQG + +E R + L ++++ E + ER + Sbjct: 181 LDDERINLNYLSVEDFIPAGGQGIIAVEGRAE-EEFSFLKDSIHNEEAMYSLEVERYVMK 239 Query: 237 RLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 +L GC PIG+Y+ + I+L + ++ R + + ++ ++ L EE+L Sbjct: 240 KLNAGCNEPIGAYSFIDKDTIFLD--IIYEHNGKVSRKKGSDSIENRLKLTEKLVEEILQ 297 Query: 297 N 297 Sbjct: 298 E 298 >UniRef50_O29026 Probable porphobilinogen deaminase n=1 Tax=Archaeoglobus fulgidus RepID=HEM3_ARCFU Length = 289 Score = 327 bits (838), Expect = 4e-88, Method: Composition-based stats. Identities = 111/294 (37%), Positives = 163/294 (55%), Gaps = 11/294 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 L + TR S LAL Q + V ++L + VE+ + T GD++ D PL + G G FV+ Sbjct: 2 KLIVGTRGSKLALAQTNKVAERLKERY---EVEIRIVKTAGDIMKDKPLYEFKGMGAFVR 58 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L+ AL E + D+AVHS KDVP + +G + + ER+ P D +S + +L+ L G++ Sbjct: 59 ALDTALAEGKVDVAVHSFKDVPSQRVEGTVVAAVIERDSPCDVLISRDGSTLEELDEGAV 118 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI- 183 VGTSSLRR+ QL+ R DL +LRGN+ TRL KL G YDAI++A AGLKRLGL+ + Sbjct: 119 VGTSSLRRRAQLSRLRGDLRFENLRGNLDTRLRKLREGNYDAIVVAEAGLKRLGLDREVE 178 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 PPE+ +P QG + I R + +L+A LN +T L ERA+ L GC Sbjct: 179 YQPFPPEVIVPPANQGIIAIATRKGEE---DLVAFLNDEKTWLEAMVERAVIKELGVGCA 235 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 VP+G YAE + L + + +R E + + A + + ++L Sbjct: 236 VPVGVYAE-AQSRVRLICEILD---KKYLRVEEKLSKDTAVEEAAEIGKDLRKE 285 >UniRef50_D1BFI8 Hydroxymethylbilane synthase n=4 Tax=Actinomycetales RepID=D1BFI8_SANKS Length = 312 Score = 327 bits (838), Expect = 5e-88, Method: Composition-based stats. Identities = 126/309 (40%), Positives = 173/309 (55%), Gaps = 14/309 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LRI TR S LAL Q V D L G VE+VP+ T GD +L L+++GG G+FV Sbjct: 7 LRIGTRSSLLALTQTGTVADDLRRL-TGRPVEIVPVTTDGD-VLTGSLSQMGGTGVFVTA 64 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L ALL++R D+AVHS+KD+P GL V R+DPRDA S L LP G+ V Sbjct: 65 LRAALLDDRCDVAVHSLKDLPTAGVLGLQHV-TPVRQDPRDALCSRAGHRLADLPHGARV 123 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--DNGEYDAIILAVAGLKRLGLESRI 183 GT S RR QL RPDL + +RGN+ TRL ++ + G+ DA++LA AGL R+G E I Sbjct: 124 GTGSPRRAAQLRLVRPDLDVVDIRGNIDTRLGRVHPETGDLDAVVLAAAGLNRIGREHAI 183 Query: 184 RAALPPEISLPAVGQGAVGIECR----LDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 + PA GQGA+ +E R +D L+ T+L V AERA+ RLE Sbjct: 184 TELISVTDMAPAPGQGALAVETRSSLLEEDPVVARAFDQLDDPATSLSVLAERALLARLE 243 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-----GAPQDAEQMGISLAEEL 294 GC P+G++A + DG + L A+V PDGS+ +R + + +A +G ++A+ Sbjct: 244 AGCAAPVGTHATVSDGLLTLHAVVARPDGSEQLRHNQSTEVADTSTAEAVALGEAVADHF 303 Query: 295 LNNGAREIL 303 L GA + Sbjct: 304 LALGAASFI 312 >UniRef50_C2FZW8 Porphobilinogen deaminase n=2 Tax=Sphingobacterium spiritivorum RepID=C2FZW8_9SPHI Length = 528 Score = 326 bits (836), Expect = 6e-88, Method: Composition-based stats. Identities = 112/311 (36%), Positives = 158/311 (50%), Gaps = 24/311 (7%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 ++ L I TR S LA+WQA+++KD+L A+ G+ EL + T+GD+I L K+ GKG Sbjct: 1 MNRKLIIGTRGSQLAMWQANHIKDRLAAA--GIDSELKVIKTQGDIIQHLRLDKLEGKGF 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY----DSLD 117 F KELE LL + D+AVHS KD+P P GL + + ERE P + + Sbjct: 59 FTKELEEELLSSTIDLAVHSHKDLPTVNPPGLIIAAVSERESPAELLIVLKDCVDIKKRL 118 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKR- 176 +L + VGTSS RR+ QL RPDL LRGN+ TR+ KL + YDAIILA AG++R Sbjct: 119 SLKHNATVGTSSNRRKAQLLSLRPDLEFDDLRGNLQTRIQKLRDENYDAIILAKAGVERI 178 Query: 177 -LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235 + L +PP +PA QG + I+ R D E L +++ E A + ER + Sbjct: 179 DMDLSDFYVEEIPPVELIPAPAQGVLAIQIRESDQELFEALQVIHNKEVAEVIAVERKVL 238 Query: 236 TRLEGGCQVPIGSYAELIDGEIWLRALVGA-----PDGSQIIRGERRGAPQDAEQMGISL 290 + GC P+G Y +G+ V PD I R G + Sbjct: 239 NLFDAGCHAPLGCYCRKSEGKYEAWTSVAETSDEFPDRLYIQRDSTEG-----------M 287 Query: 291 AEELLNNGARE 301 AEE+ A++ Sbjct: 288 AEEIFTKFAKD 298 >UniRef50_A4CHM3 Porphobilinogen deaminase n=4 Tax=Bacteroidetes RepID=A4CHM3_9FLAO Length = 315 Score = 325 bits (835), Expect = 1e-87, Method: Composition-based stats. Identities = 121/318 (38%), Positives = 167/318 (52%), Gaps = 18/318 (5%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + LRI TR S LALWQA V+D+L A+ G ELVP+ + GD++LD PL ++G G+ Sbjct: 1 MSRALRIGTRDSELALWQAQTVRDRLEAA--GHRAELVPVKSTGDLVLDKPLYELGITGI 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F K L+VALL D+AVHSMKDVP P+G+ + ER RD V + P Sbjct: 59 FTKTLDVALLREDIDLAVHSMKDVPTALPEGICQAAVLERASARDVLV-HKGLGFLDGP- 116 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 + T SLRR+ Q R P + LRGNV TRL L +D I A AGL+R+GL Sbjct: 117 -GTIATGSLRRKAQWLNRYPAHQVTGLRGNVNTRLKLLRENSWDGAIFAQAGLERIGLLP 175 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 L + LPA QGA+ + R D+ RE L+H ++AL V ER LEGG Sbjct: 176 DNAEPL--DWMLPAPAQGAMLVVARTSDTAAREAARPLHHEQSALEVAVEREFLRTLEGG 233 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER-RGAPQ----------DAEQMGISL 290 C PIG+ DG++ L + + DG + R R G+ + DA + G + Sbjct: 234 CSAPIGARVHAADGQLHLEGGLFSLDGKKAFRVTRHTGSLEAGGTGDARFQDAGEFGAAC 293 Query: 291 AEELLNNGAREILAEVYN 308 A E+L++G ++ + Sbjct: 294 AREILDSGGAVLMESIRK 311 >UniRef50_B3RTQ8 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RTQ8_TRIAD Length = 314 Score = 325 bits (834), Expect = 1e-87, Method: Composition-based stats. Identities = 120/338 (35%), Positives = 172/338 (50%), Gaps = 64/338 (18%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M + V+RI TR+S LA+ Q H V D L HP +E+V M T GD +LD L ++G Sbjct: 4 MEETVVRIGTRKSQLAMIQTHSVVDALREIHPKARIEIVTMDTIGDRVLDKALPEIGQTN 63 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF K+LEVAL +N+ D+ +HS+KDVP P+GL + I Sbjct: 64 LFTKDLEVALTDNKIDLIIHSLKDVPSTLPEGLAIAAI---------------------- 101 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGL 179 G+++GTSSLRR QL R P L ++RGN+ TRL KLD G YDA++LA AG++ Sbjct: 102 -GNVIGTSSLRRIAQLKRRFPHLKFENVRGNLNTRLKKLDESGIYDALVLAGAGVE---- 156 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 L P+ L A+GQGA+GIE R +D +T L++A ++ + AERA L+ Sbjct: 157 -------LTPDECLYAIGQGALGIEIRKNDKKTFSLISAYTDFDSLVCNAAERAFLRFLD 209 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ------------------ 281 GC VPIG Y E + ++ + V + DGS+ ++ Sbjct: 210 KGCSVPIGVYTEFTENKLKITGAVFSLDGSKRVQYSDECTISGLNAKDDCESNYESLSSI 269 Query: 282 -----------DAEQMGISLAEELLNNGAREILAEVYN 308 +AE++G +AE +L N E+LAE Sbjct: 270 LCPSEMCNSLIEAERLGKYVAEMILKNHGGEVLAEARQ 307 >UniRef50_Q47LA7 Porphobilinogen deaminase n=3 Tax=Actinomycetales RepID=HEM3_THEFY Length = 320 Score = 324 bits (832), Expect = 2e-87, Method: Composition-based stats. Identities = 127/319 (39%), Positives = 177/319 (55%), Gaps = 11/319 (3%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M R+ TR+S +A Q+ V + L A G+ VELV + + GD I L ++GG G Sbjct: 1 MSTTPARLGTRRSTMATNQSRRVAEILTAR-TGVPVELVLITSFGD-ITRAHLTQLGGTG 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 +FV L ALL + AVHS+KD+P +G+ L + ER+DPRDA + + LP Sbjct: 59 VFVSALRDALLAGEVEFAVHSLKDLPTAPTEGIVLAAVTERDDPRDALCARDGLKFADLP 118 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 G+ VGT S RR QLA RPDL +RGN TRL K+ +GE DA++LA AGL R+G Sbjct: 119 PGATVGTGSPRRVAQLAALRPDLRYVPIRGNAETRLGKVASGELDAVVLAYAGLHRVGRL 178 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDD-SRTRELLAALNHHETALRVTAERAMNTRLE 239 + + LPA GQGA+ +ECR D + L A++H T VTAER + LE Sbjct: 179 DDVTDVFDVDQVLPAPGQGALAVECRTADFTGPLRYLTAVDHLPTRAAVTAERVILAELE 238 Query: 240 GGCQVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQD-------AEQMGISLA 291 GC P+G+YAE + + + LRA V A DGSQ +R E+ + A +G LA Sbjct: 239 AGCAAPVGAYAEFVAEDRLRLRAAVVATDGSQAVRAEQTVTVTEFPDAVQAATALGRQLA 298 Query: 292 EELLNNGAREILAEVYNGD 310 +++ GA +I+A+ G Sbjct: 299 HDMIEQGADQIVADAAAGR 317 >UniRef50_C9M5W1 Hydroxymethylbilane synthase n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M5W1_9BACT Length = 714 Score = 324 bits (832), Expect = 2e-87, Method: Composition-based stats. Identities = 115/295 (38%), Positives = 160/295 (54%), Gaps = 7/295 (2%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 LR+A+R+S LA+ Q+ V ++L + G VE++P TRGD + D L GGKGLFV Sbjct: 424 RPLRLASRESELAMAQSRLVAERLHEA-TGFDVEIIPFRTRGDAVADRRLESAGGKGLFV 482 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE A+L +AD+AVHS+KD+P P GL + +R+ D V + + Sbjct: 483 KELERAILSGQADLAVHSLKDMPSSCPDGLAFAALMDRQTAFDCLVLRPGLTGRPV---- 538 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +GTSS RR Q D LRGN+ TRLSKLD GE+DA+ILA AGL+RLGL+ R+ Sbjct: 539 RIGTSSARRIAQGRALFSDAQFVPLRGNLRTRLSKLDGGEFDALILAEAGLRRLGLQERV 598 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 + +P+ GQG + ++C D +L++ L+ AERA RL GGC Sbjct: 599 SRVFSADQMIPSAGQGTLAVQCPFDGP-VFDLVSQLDEPAVRTCCLAERAFIDRLNGGCT 657 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298 P G+YA + I + L PDG + G+ G D + LA+ L G Sbjct: 658 APHGAYARVDGETIEMIGLYVRPDGKT-LSGKISGPAADGPSLAAELADRLKRRG 711 >UniRef50_Q4T5L1 Chromosome undetermined SCAF9206, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4T5L1_TETNG Length = 385 Score = 324 bits (831), Expect = 3e-87, Method: Composition-based stats. Identities = 134/383 (34%), Positives = 191/383 (49%), Gaps = 85/383 (22%) Query: 13 SPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLE 72 S LA Q V +KL +P + +E+V M T GD ILDT L+K+G K LF KELE AL Sbjct: 1 SQLARIQTDSVAEKLKELYPDVHLEIVAMSTTGDKILDTALSKIGEKSLFTKELENALER 60 Query: 73 NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALPAGSIVGTSS 129 N D+ VHS+KD+P P G + + +RE+P DA V + +LDALPA S++GTSS Sbjct: 61 NEVDLVVHSLKDLPTSLPPGFTIGAVLKRENPHDAVVLHPKNAGKTLDALPAHSVIGTSS 120 Query: 130 LRRQCQLAERRPDLIIRSL------------------------RGNVGTRLSKLDN-GEY 164 LRR QL +R P L + + RGN+ TRL KLD ++ Sbjct: 121 LRRAAQLKKRFPHLDFKDIVSSERCFLPVQPGHRCFFLSSRSQRGNLNTRLKKLDEKEDF 180 Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224 AIILA AGL+R+G ++RI L PE + AVGQGA+ +E R D+ E+++ L+ +T Sbjct: 181 AAIILAAAGLRRMGWDNRISQILEPEDCMYAVGQGALAVEVRAKDADILEMVSVLHDPDT 240 Query: 225 ALRVTAERAMNTRL----------------------------EGGCQVPIGSYAELIDGE 256 LR AERA L EGGC VP+ + ++ D + Sbjct: 241 VLRCIAERAFLKHLVQHTHTHTHTHTHTRSLAVAHWNLFCLQEGGCSVPVAVHTKVKDSQ 300 Query: 257 IWLRALVGAPDGSQIIRGERR--------GAPQD---------------------AEQMG 287 ++L V + DGS ++ + G+P + AE++G Sbjct: 301 LYLTGAVYSLDGSDSLKETMQTSVAAPADGSPDEVDECARVGVTANKIPGEAQDRAERLG 360 Query: 288 ISLAEELLNNGAREILAEVYNGD 310 + LA+ LL+ GA+EIL + Sbjct: 361 VDLAKLLLSKGAKEILTVARQLN 383 >UniRef50_A8AAB4 Probable porphobilinogen deaminase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=HEM3_IGNH4 Length = 304 Score = 324 bits (831), Expect = 3e-87, Method: Composition-based stats. Identities = 113/295 (38%), Positives = 158/295 (53%), Gaps = 7/295 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILD--TPLAKVGGKGLF 62 ++IA R S L+L Q L+ P L E++ + T GD LAK G GLF Sbjct: 2 KIKIAARGSKLSLKQVSMFTSYLLKFFPDLEYEVITVKTTGDKANAPFEELAKRGLTGLF 61 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALPA 121 KE+ A+LE +AD+AVHS+KD+P E L + R+ P D +S + LP Sbjct: 62 EKEVNKAVLEGKADVAVHSLKDLPTELDPRLEIAAFLPRDPPYDVLISRAGNYDIFDLPK 121 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 GS+VGTSS RR+ + RPDL+++ LRGNV TRL KL GEYDAI+LA AG+ RLGL + Sbjct: 122 GSVVGTSSARRKALIKNLRPDLVVKDLRGNVDTRLEKLRRGEYDAIVLAEAGVSRLGL-N 180 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 L + P+ GQG + R S +LL +++ ++ TAER + GG Sbjct: 181 VDYVRLDWRLFPPSPGQGIIVAVTRKG-SEISDLLKSISDVKSEKLATAERTVLKEFGGG 239 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 C V +G+ A I LRA V +P G + + E G + E++G+ AE L Sbjct: 240 CFVALGAIAFEEGSLIRLRATVLSPSGRERVDVELIG--KGPEEVGMRAAERLKA 292 >UniRef50_D2RH82 Porphobilinogen deaminase n=2 Tax=Archaeoglobaceae RepID=D2RH82_ARCPR Length = 292 Score = 323 bits (830), Expect = 4e-87, Method: Composition-based stats. Identities = 107/296 (36%), Positives = 161/296 (54%), Gaps = 9/296 (3%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + + + TR S LAL Q V ++L G VE+ + + GD++ D PL + G G Sbjct: 1 MSERVVVGTRGSKLALAQTSKVVERLKEE--GYSVEIRIIKSTGDIMKDKPLYEFKGSGA 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FV+ LE AL+ D+AVHS KD+P +G+ + + ER+ P DAF++ N +SL+ + Sbjct: 59 FVRALEHALVRGEIDVAVHSYKDIPSNMLEGVTVSAVLERDSPYDAFIARNGESLEEIKP 118 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 +++GTSSLRR+ QL R DL +LRGNV TRL KL G YDAI+LA AG++RLGL Sbjct: 119 NAVIGTSSLRRRAQLKLYRSDLRFENLRGNVDTRLRKLREGLYDAIVLAEAGIQRLGLNV 178 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + LP E +P QG + ++ R+ + +L+ +NH ET + ER + L G Sbjct: 179 KY-QRLPIERFVPPANQGIIAVQTRVGEE---DLVKFMNHEETWIEAEVERIVMKTLGVG 234 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 C +P G YAE ++ L V DG + + + + A + +AE Sbjct: 235 CAIPAGIYAECRG-KVRLIVQVIR-DGRE-FKVIEELSRESAIEEAREIAENFREE 287 >UniRef50_C6XST0 Porphobilinogen deaminase n=2 Tax=Pedobacter RepID=C6XST0_PEDHD Length = 526 Score = 323 bits (830), Expect = 4e-87, Method: Composition-based stats. Identities = 115/270 (42%), Positives = 157/270 (58%), Gaps = 8/270 (2%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L I TR S LALWQA+++KDKL A G+ EL + T+GD IL+ L K+ GKG F Sbjct: 2 KRLIIGTRGSDLALWQANFIKDKLAAI--GVEAELKIIKTQGDKILNLRLDKLEGKGFFT 59 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRD-AFVSNNYDSLD---AL 119 KELE LL DIAVHS KD+P P GL + + EREDP + + + S++ +L Sbjct: 60 KELEEELLGGTIDIAVHSHKDLPTVHPAGLTIAAVTEREDPSELLLILKDCVSINHKLSL 119 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG- 178 G++VGTSS RR+ QL RPDL I LRGNV TR+ KL + +YDAI+LA AG+ RL Sbjct: 120 KKGAMVGTSSNRRKAQLLALRPDLNIEDLRGNVPTRIQKLRDEDYDAILLARAGVNRLNI 179 Query: 179 -LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 L + +PA QGA+ I+ R +++ ++L +NH ETA + ER + Sbjct: 180 DLSEFHVEVVDTTELVPAPAQGALAIQIRENENELFDILQQINHSETAEEIAIERKVLNL 239 Query: 238 LEGGCQVPIGSYAELIDGEIWLRALVGAPD 267 EGGC +P+G Y + DG+ + D Sbjct: 240 FEGGCHMPLGCYCKKEDGQYEVWTSKAETD 269 >UniRef50_A3MLK5 Porphobilinogen deaminase n=155 Tax=Proteobacteria RepID=HEM3_BURM7 Length = 329 Score = 323 bits (828), Expect = 6e-87, Method: Composition-based stats. Identities = 162/315 (51%), Positives = 208/315 (66%), Gaps = 3/315 (0%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 L L IA+R+S LA+WQA +V+D L +P V+++ M TRGD ILD L+KVGGKGL Sbjct: 10 LPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGL 69 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKELE AL + RAD+AVHS+KDVP+ P+G L + REDPRDAFVSN+Y SLDALPA Sbjct: 70 FVKELESALADGRADLAVHSLKDVPMALPEGFALAAVMSREDPRDAFVSNDYASLDALPA 129 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G++VGTSSLRR+ L R P L +R LRGN+ TRL+KLD G+Y AIILA AGLKRLGL + Sbjct: 130 GAVVGTSSLRREAMLRARHPRLDVRPLRGNLDTRLAKLDRGDYAAIILAAAGLKRLGLAA 189 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 RIRA L + SLPA GQGA+GIE + LA L+ H +AL V AERA++ L G Sbjct: 190 RIRALLDVDDSLPAAGQGALGIEIAARRADVAAWLAPLHDHASALAVEAERAVSRALGGS 249 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQI---IRGERRGAPQDAEQMGISLAEELLNNG 298 C+VP+ ++A GE+ L V DG+++ R DA +G +++ L G Sbjct: 250 CEVPLAAHAVWRGGELHLTGSVSTTDGARVLAAHAHARAATAADALALGRRVSDALERQG 309 Query: 299 AREILAEVYNGDAPA 313 AR I+ + A A Sbjct: 310 ARAIVDALVAASAQA 324 >UniRef50_D2NS36 Porphobilinogen deaminase n=2 Tax=Micrococcaceae RepID=D2NS36_9MICC Length = 454 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 134/372 (36%), Positives = 186/372 (50%), Gaps = 71/372 (19%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPG------------LVVELVPMVTRGDVI 48 M + + TR S LAL Q+ + + + + + L + T GD + Sbjct: 78 MSHHEYILGTRGSALALTQSRIAAETVTSLYTEHQAHHGAADAEVVDFTLRTVKTEGD-V 136 Query: 49 LDTPLAKVGGKGLFVKELEVALLENR-------ADIAVHSMKDVPVEFPQGLGLVTICER 101 L PLA +GG G+F L LL+ D+AVHS+KD+P GL + +R Sbjct: 137 LTGPLATLGGTGVFAAALRQRLLDGENASEENRVDMAVHSLKDLPSAPCPGLVIAATLKR 196 Query: 102 EDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-- 159 EDPRDA V+ + +LD LP GS VGT S RR QL RPDL I +RGNVGTR+ ++ Sbjct: 197 EDPRDALVARDGLTLDTLPEGSRVGTGSPRRAAQLRALRPDLEIVDIRGNVGTRIGRVKG 256 Query: 160 ----------------------------DNGEYDAIILAVAGLKRLGLESRIRAALPPEI 191 +G+ DA++LAV+GLKRLG E I L P Sbjct: 257 LEEHAGKQVVLRQNTETSERADHGVGTERSGDCDAVVLAVSGLKRLGKEELITEYLDPTR 316 Query: 192 SLPAVGQGAVGIECRLD-----------DSRTRELLAAL-------NHHETALRVTAERA 233 LPA GQGA+ +E R D + AL NHHET L V+AERA Sbjct: 317 MLPAPGQGALALEVRESEFENPDPAVLADPEVARPVRALGRALLAANHHETRLAVSAERA 376 Query: 234 MNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---AEQMGISL 290 + RLE GC PIG+YA +++G++ L +V +PDG+ ++R A D AE++G+ + Sbjct: 377 LLRRLEAGCAAPIGAYAHVVEGDLVLSVVVASPDGTDMLRHTSATAELDVPGAERLGVRV 436 Query: 291 AEELLNNGAREI 302 AE+LL GA + Sbjct: 437 AEDLLQMGAAAL 448 >UniRef50_C1TM53 Porphobilinogen deaminase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TM53_9BACT Length = 454 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 124/289 (42%), Positives = 159/289 (55%), Gaps = 8/289 (2%) Query: 10 TRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVA 69 +R+S LA Q L GL VE+ M T GD D L+ GG G FVK LE A Sbjct: 160 SRKSALARAQTMEAARALAKK--GLPVEIKTMSTCGDEKQDCHLSAFGGNGAFVKCLEEA 217 Query: 70 LLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSS 129 ++E + D A+HS+KDVP P GL LV + R D VSN+ L+ LPAG++VGTSS Sbjct: 218 IMEGKGDGAIHSLKDVPSVLPDGLELVAVLPRASTSDVIVSNHKGGLEGLPAGAVVGTSS 277 Query: 130 LRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPP 189 LRR+ QLA RPDL +RGNV TRL+KL +G+ DAI+LA AGL RLG+ LP Sbjct: 278 LRRKAQLAITRPDLDYTLIRGNVNTRLAKLQSGDADAIVLAKAGLDRLGISPEGATTLP- 336 Query: 190 EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSY 249 LPA QG + +E R SR E A+NH T L AER + L+ GC VP + Sbjct: 337 --FLPAPCQGIIAVEARSG-SRLAEEFRAINHRPTWLMALAERELLESLQVGCHVPFAAL 393 Query: 250 AELIDGEIWLRALVGAPDGSQI-IRGERRG-APQDAEQMGISLAEELLN 296 +E + GE+ LRA + DG I G + DA +G +A + Sbjct: 394 SEWVGGELRLRAQTLSYDGRHIDFEGSLAVRSDDDARDLGRDVALSIKA 442 >UniRef50_UPI000174444E Hydroxymethylbilane synthase n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI000174444E Length = 318 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 119/307 (38%), Positives = 156/307 (50%), Gaps = 18/307 (5%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG----- 57 + LR+ TR S LAL QA V+ L A+HP L VE + T GD D ++ Sbjct: 6 TDTLRLGTRGSELALRQAEMVEAALHAAHPYLRVERKVIATTGDKRPDLRFSEFTEGDRL 65 Query: 58 GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD 117 KG+F KELE+AL DIAVHS+KDVP + + + R D +S +L Sbjct: 66 DKGIFTKELEIALASGEIDIAVHSLKDVPTVLDEKFFIAGVLPRAPIEDVLISREGYTLA 125 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG-EYDAIILAVAGLKR 176 LPAG+ VGTSS+RR QL P + +RGNV TR+ KL + DAI+LA AGL+R Sbjct: 126 TLPAGAKVGTSSVRRIRQLQWLNPGVECVEIRGNVPTRIRKLFAPSDLDAILLARAGLER 185 Query: 177 LGLES----------RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETAL 226 L L L E LPA GQGA+GIE R+DD+ T E L A+NH ET Sbjct: 186 LSLLDGEHVVVDGQPLHAVILDCEEFLPAAGQGAIGIEARVDDAHTLEFLKAINHEETYA 245 Query: 227 RVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPD--GSQIIRGERRGAPQDAE 284 RVTAER L+ GCQ PIG++ L +G + ++ V G + Sbjct: 246 RVTAEREFLHILKAGCQTPIGAHTFLENGVLQMKVRVFDETDPGRPPKEVTSTEPYHSPK 305 Query: 285 QMGISLA 291 + +A Sbjct: 306 GLAAEVA 312 >UniRef50_C2GGB5 Porphobilinogen deaminase n=2 Tax=Corynebacterium glucuronolyticum RepID=C2GGB5_9CORY Length = 290 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 121/299 (40%), Positives = 165/299 (55%), Gaps = 11/299 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR S LA QA +V+D L+ + G EL + T GD L +P+ K+G G+F + Sbjct: 2 TLRIGTRGSKLATTQAGHVRDALIRA--GYDAELTIITTPGDKNL-SPVQKIG-VGVFTQ 57 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L A+ + DIAVHS KD+P P+GL + RE P +A ++ + +LD LP G+ Sbjct: 58 ALREAMDRDEIDIAVHSCKDLPTGQPEGLATI-YPVRETPCEALIARDGLTLDQLPEGAK 116 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGT + RR QL RPDL IR LRGNV TR+ K+ +GE DA+ILA AGL R+G Sbjct: 117 VGTGAPRRISQLKALRPDLDIRPLRGNVDTRMGKVTSGELDAVILAHAGLTRIGRGDEAT 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 P +PA QG + +E R L ++ H T L AERA+ + L+ GC Sbjct: 177 QVFDPTYLMPAPAQGILAVESRTHVDAISTL---IDDHAT-LSAQAERAVLSTLQAGCTA 232 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 P+ +Y+ + EI L A A DGS+ I G D +G S+AE+L GA EI+ Sbjct: 233 PLAAYSTVSGDEITLTAGAFALDGSKQIVETATGT--DPVALGTSVAEKLRACGAEEII 289 >UniRef50_D1VCA1 Porphobilinogen deaminase n=1 Tax=Frankia sp. EuI1c RepID=D1VCA1_9ACTO Length = 380 Score = 321 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 124/344 (36%), Positives = 179/344 (52%), Gaps = 44/344 (12%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 L + LR+ TR+S LAL Q+ V D+L G+ V+LV +VT GD ++++G G+ Sbjct: 36 LPSRLRLGTRRSALALAQSGMVADELRTR-LGIEVDLVHVVTEGDRNR-AEISQLGSTGV 93 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 +V L ALL D+AVHS+KD+P P+G+ L I RED RD VS +L L Sbjct: 94 WVSALREALLSGEVDLAVHSLKDLPTAPPEGITLAAIPPREDVRDVLVSPTGRTLAQLGP 153 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ +GT + RR QL L + +RGNV TR+ K +GE DA++LA AGL RL Sbjct: 154 GARIGTGAPRRAAQLRALGLGLDVVPIRGNVDTRIKKAIDGEVDAVVLARAGLARLDRLD 213 Query: 182 RIRAALPPEISLPAVGQGAVGIECRL--------------DDSR---------------- 211 I L PE+ LPA GQGA+ IEC +D Sbjct: 214 AITELLEPEVMLPAPGQGALAIECVATTLAPLTLLTVGTPEDQGAVTGMSCPVAPGSGVE 273 Query: 212 --TRELLAA-LNHHETALRVTAERAMNTRLEGGCQVPIGSYAEL---------IDGEIWL 259 LL L+ +++ V AERA +E GC P+G+ A++ +GE+ L Sbjct: 274 IPLERLLRFVLDDAPSSVAVRAERAFLAAIEAGCTAPVGALAQVLPARGQAPASEGEVRL 333 Query: 260 RALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 RA+V + DG+ ++R E G+ D E +G LA++LL+ GA ++ Sbjct: 334 RAVVASLDGTTVLRRELGGSTADPEALGRRLADDLLSAGAHTLM 377 >UniRef50_A4WN24 Probable porphobilinogen deaminase n=3 Tax=Thermoproteaceae RepID=HEM3_PYRAR Length = 297 Score = 321 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 110/293 (37%), Positives = 157/293 (53%), Gaps = 6/293 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L +ATR S L++ Q + ++ A P + E+ + T GD + D PL ++G KG+F KE Sbjct: 3 LVVATRGSKLSMLQTEELLAQIKAVEPSIEFEIKIVKTTGDEVQDKPLYQIGVKGIFEKE 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 + +A+L AD+AVHS+KD+P E GL L +R P DA VS L+ LP G++V Sbjct: 63 VNLAVLRGEADVAVHSLKDLPSELSPGLVLAGFSKRAPPFDAVVSTAGYVLETLPRGALV 122 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL-GLESRIR 184 GTSS+RR + RPD+ + LRGNV TR++K+ G+YDA I+AVAG+ RL G I+ Sbjct: 123 GTSSVRRAEFVKAIRPDVRVEPLRGNVDTRINKILQGKYDAAIMAVAGIYRLYGASPPIK 182 Query: 185 -AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 A L PE+ P GQG V R DS +LL + + +L AER + GC Sbjct: 183 LAVLRPEVLPPPPGQGIVAAVVREADSWLIDLLKKASDPKASLEAIAEREFLKAVGAGCH 242 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 V IG A + + A + G + G D ++G AEE+ Sbjct: 243 VAIGGVAFARNDTVEFIAGYAS--GGRKYIVRVVG--DDPVEVGRRAAEEIRK 291 >UniRef50_Q2NEP4 HemC n=4 Tax=Methanobacteriaceae RepID=Q2NEP4_METST Length = 290 Score = 320 bits (822), Expect = 3e-86, Method: Composition-based stats. Identities = 91/292 (31%), Positives = 149/292 (51%), Gaps = 4/292 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 + + TR S LA Q V L G +E + T GD I ++ L + KG+F KE Sbjct: 1 MIVGTRGSKLATTQTKTVVKALEEIT-GEEIETKIIKTTGDKIKNSQLYNIDAKGIFTKE 59 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L+ AL++ D AVHS KD+P E L + I +RE + +SN S D LP + + Sbjct: 60 LDTALIDGSIDFAVHSFKDLPSELNDQLTITAIPQREAINEVLISN--YSWDELPENATL 117 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR+ + + +RGN+ TR+ K++ GEYDA I+A+AG+ RLGL+ I+ Sbjct: 118 GTSSVRREAFCKLHGKKIQTKPIRGNIDTRIRKVEEGEYDATIMALAGINRLGLQEHIKE 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 + P GQGA+ + DS ++++ LNH ++ + E+A+ + GCQ P Sbjct: 178 VFDEQYITPPAGQGALAVMTHK-DSEYNDVISKLNHEDSRIEAMTEKAILETIGVGCQWP 236 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 IG +++ I + + +P+G + + +A + +L + Sbjct: 237 IGIVSKVDGNNINIHCKLLSPEGKLLADVNKTTDKNNAINTAKVIGTKLRED 288 >UniRef50_Q9F7M2 Predicted porphobilinogen deaminase n=2 Tax=Bacteria RepID=Q9F7M2_PRB01 Length = 303 Score = 320 bits (821), Expect = 4e-86, Method: Composition-based stats. Identities = 111/306 (36%), Positives = 173/306 (56%), Gaps = 4/306 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +RIATRQS LA++QA +V D+L+A + VELVPM + GD D PL ++GGKGLF+ Sbjct: 2 KIRIATRQSELAMYQAKFVADELLAKINNIKVELVPMTSEGDQ-TDKPLHEIGGKGLFIS 60 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 LE +L + ADIAVHS+KDVP + ++++ RE P D +S + S S Sbjct: 61 TLESSLEADEADIAVHSLKDVPAKLDPKFKIISVFSRESPEDLLLSKDGKSFSEFARNST 120 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTS RR+ Q+ RPD+ +RGN+ TR+ KL++G +D +++A A +KRLGL+ Sbjct: 121 IGTSGPRRKAQINNLRPDIKTIPVRGNIATRIKKLNDGLFDGLVVAKAAIKRLGLKQNSY 180 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 E LP+ QG + IEC D ELL + + + +AER+ +EG C Sbjct: 181 E-FSIEEMLPSASQGYIAIECLSDKKDIIELLENIGDPKELILASAERSFVAAMEGTCLS 239 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 PI E +G+I + + + +G++ I E+ + QD + A+E + GA+ ++ Sbjct: 240 PIAILCEDKNGQIKISGKILSYEGNEKIYKEKISSFQDIAIDIMLFADEFILEGAKSLI- 298 Query: 305 EVYNGD 310 + N + Sbjct: 299 -LKNDN 303 >UniRef50_C6R3Y0 Hydroxymethylbilane synthase n=1 Tax=Rothia mucilaginosa ATCC 25296 RepID=C6R3Y0_9MICC Length = 377 Score = 319 bits (819), Expect = 7e-86, Method: Composition-based stats. Identities = 134/372 (36%), Positives = 186/372 (50%), Gaps = 71/372 (19%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLV------------VELVPMVTRGDVI 48 M + + TR S LAL Q+ + + + + EL + T GD + Sbjct: 1 MSHHEYTLGTRGSALALTQSRIAAETVTSLYTEHQAHHGAENPEAVSFELRTVKTEGD-V 59 Query: 49 LDTPLAKVGGKGLFVKELEVALLENR-------ADIAVHSMKDVPVEFPQGLGLVTICER 101 L PLA +GG G+F L LL+ D+AVHS+KD+P GL + +R Sbjct: 60 LTGPLATLGGTGVFAAALRQRLLDGENASEENRVDMAVHSLKDLPSAPCPGLVVAATLKR 119 Query: 102 EDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-- 159 EDPRDA V+ + ++D LP GS VGT S RR QL RPDL I +RGNVGTR+ ++ Sbjct: 120 EDPRDALVARDGLTVDTLPEGSRVGTGSPRRAAQLRALRPDLEIVDVRGNVGTRIGRVKG 179 Query: 160 ----------------------------DNGEYDAIILAVAGLKRLGLESRIRAALPPEI 191 +G+ DA++LAV+GLKRLG E I L P Sbjct: 180 LEEHAGKQVVLRQNAETSERADHGVGTERSGDCDAVVLAVSGLKRLGKEELITEYLDPTR 239 Query: 192 SLPAVGQGAVGIECRLD-----------DSRTRELLAAL-------NHHETALRVTAERA 233 LPA GQGA+ +E R D + AL NHHET L V+AERA Sbjct: 240 MLPAPGQGALALEVRESEFENPDSAVLADPEVARPVRALGRALLAANHHETRLAVSAERA 299 Query: 234 MNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---AEQMGISL 290 + RLE GC PIG+YA +++G++ L +V +PDG+ ++R A D AE++G+ + Sbjct: 300 LLRRLEAGCAAPIGAYAHVVEGDLVLNVVVASPDGTDMLRHTSATAELDVPGAERLGVRV 359 Query: 291 AEELLNNGAREI 302 AE+LL GA + Sbjct: 360 AEDLLQMGAAAL 371 >UniRef50_A0QLI0 Porphobilinogen deaminase n=69 Tax=Actinomycetales RepID=HEM3_MYCA1 Length = 315 Score = 318 bits (816), Expect = 2e-85, Method: Composition-based stats. Identities = 133/311 (42%), Positives = 175/311 (56%), Gaps = 13/311 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LA QA V+D L+A G ELV + T GD P+ +G G+F Sbjct: 2 IRIGTRGSLLATTQAGGVRDALIAR--GHPAELVTITTAGDR-SSGPIESLG-VGVFTTA 57 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L A+ E R D AVHS KD+P + I R DPRDA V+ + L LP GS+V Sbjct: 58 LREAIEEGRVDAAVHSHKDLPTADDPRFAVAAIPARNDPRDAVVARDGLVLGELPPGSLV 117 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS RR QL L IR LRGN+ TRL+++ +G+ DAI++A AGL RLG + Sbjct: 118 GTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLGDVTE 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L P LPA QGA+ +ECR DSR +LA L+ +T VTAERA+ LE GC P Sbjct: 178 TLEPVQMLPAPAQGALAVECRAGDSRLAAVLAELDDADTRASVTAERALLAELEAGCSAP 237 Query: 246 IGSYAELID---------GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 +G+ AE+++ E+ LR V A DGS +IR G P A ++G+S+A EL Sbjct: 238 VGAIAEVVESIDEDGRIFEELSLRGCVAALDGSDVIRASGIGTPGRARELGLSVAAELFE 297 Query: 297 NGAREILAEVY 307 GARE+++ Sbjct: 298 LGARELMSGAR 308 >UniRef50_Q8D2W2 HemC protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis RepID=Q8D2W2_WIGBR Length = 291 Score = 318 bits (816), Expect = 2e-85, Method: Composition-based stats. Identities = 132/289 (45%), Positives = 193/289 (66%), Gaps = 1/289 (0%) Query: 20 AHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAV 79 + K KL+ HP L ++LVP++T GD+I KGLF+KELE +LL+ ++DIAV Sbjct: 3 SKLCKKKLLHYHPKLNIKLVPILTTGDLINKIRNNITNEKGLFIKELEKSLLKYQSDIAV 62 Query: 80 HSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAER 139 HSMKD F LGL IC+R+DPRDA VSN Y+++ +LP + VGTSSLRR+CQL Sbjct: 63 HSMKDFSSSFLDSLGLAAICKRDDPRDAIVSNYYNNIISLPNNAKVGTSSLRRKCQLLSI 122 Query: 140 RPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQG 199 RPDL I +GN+ +RL KL+ G +DA+ILA A LKRL + ++ + P LPA+GQG Sbjct: 123 RPDLKIFPCKGNIHSRLKKLNQGVFDALILATAALKRLKINEQMYTPIDPSYLLPAMGQG 182 Query: 200 AVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID-GEIW 258 ++ I+CRL D++ +++ +N+ +TAL + +E+ + + L GC+VPIGSYA++ + IW Sbjct: 183 SIAIQCRLYDNKIIDIVRNINNKKTALCINSEKIVVSMLGTGCRVPIGSYAKIENKNTIW 242 Query: 259 LRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVY 307 +RALVG+ DGS IIR E + +AE++ + L+N GA+ IL + Sbjct: 243 IRALVGSIDGSNIIRSEGKSCVSNAEKLSKKQVKNLINLGAKNILKKFK 291 >UniRef50_C0BZ93 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM 15053 RepID=C0BZ93_9CLOT Length = 298 Score = 318 bits (815), Expect = 2e-85, Method: Composition-based stats. Identities = 118/296 (39%), Positives = 161/296 (54%), Gaps = 5/296 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + +++RI +R+S LA+ QA VK + + P + E+V M T GD ILD L GGKGL Sbjct: 1 MQSIIRIGSRESRLAVKQAEIVKQAVERNCPDIKAEIVTMKTEGDKILDRRLELAGGKGL 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FVKELE ALL+ R DI VHS+KDVP+E P+ L +V EREDPRD + + ++P Sbjct: 61 FVKELEKALLDGRIDICVHSLKDVPMEVPEDLPVVAFGEREDPRDVLIYKPGRT--SIPE 118 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G ++GTSS RR+ QL P RS+RGNV TRL KL +D +LA AGLKRL +E Sbjct: 119 GGVIGTSSRRRELQLKRLYPSCTFRSIRGNVQTRLRKLSEEGFDGTVLAAAGLKRLHMEE 178 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 + +PAVGQG + ++ R L + ++ AER L GG Sbjct: 179 VAGRVFSVDEIIPAVGQGILAVQGRKGRDY--SWLTSFACGKSRAEAEAEREFAAALGGG 236 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 C P+ ++A+ E+ L L G R G A Q+G +LAEE+ Sbjct: 237 CTSPVAAHAQAQGAELKLTGLYYC-GGDIYRTRTRTGETDRARQLGAALAEEMRRE 291 >UniRef50_Q57989 Probable porphobilinogen deaminase n=11 Tax=Methanococcales RepID=HEM3_METJA Length = 292 Score = 317 bits (812), Expect = 4e-85, Method: Composition-based stats. Identities = 106/296 (35%), Positives = 156/296 (52%), Gaps = 10/296 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LAL+QA+ V + L G VE+ + T GD +LD L+ +G G+F KE Sbjct: 2 IRIGTRGSKLALYQANKVAELLKNL--GYKVEIKIIKTTGDRVLDKKLSDIG-IGVFTKE 58 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L++A+L N DIAVHS+KD+P + + L + + ER+ D + N + + ++ Sbjct: 59 LDLAMLNNEIDIAVHSLKDIPTIWNENLMVGAVLERDSYHDLLIWNKDIDFNE-DSKIVI 117 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS+RR+ L P+ LRGNV TRL KL G YDAI+L+ AG+ RLG+ Sbjct: 118 GTSSMRRRAFLKFIYPNAKFELLRGNVDTRLRKLKEGLYDAIVLSEAGIIRLGVSLEDFN 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 +I LPA QG + + C+ DD + +L +NH T L ER GGC VP Sbjct: 178 YKRLDI-LPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSVP 236 Query: 246 IGSYAELIDGE--IWLRALVGAPDGSQIIRGERRGAPQD---AEQMGISLAEELLN 296 G+ A + + L+A V D + GE + + A ++G + +L N Sbjct: 237 FGALAVYDEKNELLKLKAAVVTNDELKNASGEVKCKIDEIDKAVELGKKIGLKLKN 292 >UniRef50_A1DGB8 Porphobilinogen deaminase n=1 Tax=Neosartorya fischeri NRRL 181 RepID=A1DGB8_NEOFI Length = 363 Score = 316 bits (811), Expect = 5e-85, Method: Composition-based stats. Identities = 120/342 (35%), Positives = 162/342 (47%), Gaps = 39/342 (11%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKL-MASHPGLVVELVPMVTRGDVILDTPLAKVG---- 57 + V+ R+S LAL Q +V KL P ++ GD P A + Sbjct: 20 EEVVIFGCRKSELALVQTRWVTSKLGQTLDPSPTFQIATGSAVGDADKQAPFAVLSKLTG 79 Query: 58 ----GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN-- 111 GK L+ ELE+ L+ + VHS+KD+P P L + ERED DA Sbjct: 80 GSDIGKSLWTNELELDLVAGKVHCLVHSLKDMPTTLPPHCLLGAVPEREDCSDAVCMRSD 139 Query: 112 -NYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAII 168 + S+D LP GSIVGTSS RR+ + P L + RGNV TRL+KLD + I+ Sbjct: 140 LKFTSIDQLPPGSIVGTSSSRRKALVRRNWPHLEVVECRGNVDTRLAKLDAPSSRFSCIL 199 Query: 169 LAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRV 228 LA AGL RLGL RI L I AVGQGA+G+E D EL+ ++H + R Sbjct: 200 LATAGLLRLGLGHRITHRLDDSIFPYAVGQGALGLEVSTDRPDILELVRHVDHKPSRWRG 259 Query: 229 TAERAMNTRLEGGCQVPIGSYAELI----------------------DGEIWLRALVGAP 266 AERAM L+GGC PIG + L G + LRA+V Sbjct: 260 IAERAMLRSLQGGCSSPIGVQSSLEPLGKEENGSTEDDSQRGRDSSSGGNLSLRAMVLHI 319 Query: 267 DGSQIIRGERRGAP---QDAEQMGISLAEELLNNGAREILAE 305 +G+ I E ++AE +G+S+A LL GAR ++ + Sbjct: 320 EGTSEIVAEDMATVRCDEEAELLGVSVANMLLAKGARGLMPK 361 >UniRef50_UPI0001BC2D4C glutamyl-tRNA reductase n=1 Tax=Brevibacterium linens BL2 RepID=UPI0001BC2D4C Length = 825 Score = 316 bits (810), Expect = 8e-85, Method: Composition-based stats. Identities = 115/333 (34%), Positives = 169/333 (50%), Gaps = 30/333 (9%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 +R+ TR+S LA Q+ + +L A G VE+V +VT GDV + +PL GG G+ Sbjct: 475 SGRTIRLGTRRSKLARSQSTAIAHQLAAL-TGWRVEIVEVVTEGDVNM-SPLTGFGGTGV 532 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FV + AL + + DIAVHS+KD+P G+ + I R DP D + + S LPA Sbjct: 533 FVSAVRQALHQGKIDIAVHSLKDLPTTPEAGIQMAAIPPRVDPADVLIGRDGLSFAELPA 592 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 GS+VGT S RR QL RPD+ +R +RGNV TR++ + +G DA++LA AG++R+G + Sbjct: 593 GSVVGTGSPRRAVQLRAARPDIEVRGVRGNVDTRIAHVRDGRLDAVVLAAAGVRRIGRLA 652 Query: 182 RIRAALPPEISLPAVGQGAVGIECR-------------LDDSRTRELLAALNHHETALRV 228 +L + LPA GQGA+ +E R D+ R L L+ T L V Sbjct: 653 EATDSLDFDTMLPAPGQGALAVETRGADSPFALDNEVMEADAEVRTQLKRLHDETTDLAV 712 Query: 229 TAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER------------ 276 T ERA+ +R E GC PIG+ A + + + A++ DG + Sbjct: 713 TCERAILSRAEAGCSAPIGALATIQGSDFVVDAVMADDDGKLARTRQVAPLPTTPDVDLD 772 Query: 277 RGAPQDAEQMGISLAE---ELLNNGAREILAEV 306 G+ G LA EL A ++L ++ Sbjct: 773 SGSANQLSITGKELARLADELGTAAAEDLLGQL 805 >UniRef50_D1C4S0 Porphobilinogen deaminase n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C4S0_SPHTD Length = 311 Score = 315 bits (809), Expect = 9e-85, Method: Composition-based stats. Identities = 124/299 (41%), Positives = 161/299 (53%), Gaps = 2/299 (0%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +R+ TR S LA Q V L A P L + + T GD TPL +GG+G+F +E Sbjct: 11 VRLGTRGSALAREQTRRVMAALAALRPDLELIETIVSTAGDRDKRTPLTVIGGQGVFARE 70 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L+ ALL D+AVHS KD+P E GL + RED RD VS + SL LP G+ V Sbjct: 71 LQTALLAGTVDVAVHSAKDLPTEPVPGLVIGAFFSREDARDVLVSRDGRSLADLPPGARV 130 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSS RR L RPDL LRGN+ TRL K+ GE DA ILA AGL R+G + I Sbjct: 131 GTSSRRRLVALRRLRPDLEAVDLRGNLDTRLRKVREGEVDAAILAAAGLLRMGWQEHITE 190 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L + +PA GQGA+ IECR DD E+LAALN AL ER+ L GGC+ P Sbjct: 191 FLSLDDFVPAPGQGALAIECRADDPAVNEMLAALNDPAAALAARTERSFLRALGGGCRSP 250 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN--NGAREI 302 IG++A + + LR ++G +++ +AE +LA E+ GA + Sbjct: 251 IGAHATVSGDTVTLRVMLGDEAMTRVRLSTWTLPAAEAETRAGALAVEVQRSLAGADPL 309 >UniRef50_O26960 Probable porphobilinogen deaminase n=1 Tax=Methanothermobacter thermautotrophicus str. Delta H RepID=HEM3_METTH Length = 289 Score = 315 bits (808), Expect = 1e-84, Method: Composition-based stats. Identities = 102/286 (35%), Positives = 153/286 (53%), Gaps = 4/286 (1%) Query: 9 ATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEV 68 TR S LAL Q ++V + L + + + +GD I D+ L + +GLF +EL++ Sbjct: 4 GTRGSRLALVQTNHVIEMLSEVCKEKIEKKIIKT-KGDRIRDSQLYSMDSRGLFTRELDM 62 Query: 69 ALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTS 128 A+L D+AVHS+KDVP + L + + RE P + VS + LP GS +GTS Sbjct: 63 AVLNEEVDLAVHSLKDVPSDLDPDLAIAAVPPRESPAEVLVSR--LDWEDLPQGSKLGTS 120 Query: 129 SLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALP 188 SLRR+ + + + LRGN+ TR+ K+ +GE A I+A AGLKRLGLE I+ P Sbjct: 121 SLRREAFCNHHQKNFKMEPLRGNIDTRIRKVMDGEVHATIMAEAGLKRLGLEEHIKRRFP 180 Query: 189 PEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGS 248 E PA GQGA+ + R DS + + HH + VTAE+ + L GCQ P+G Sbjct: 181 VEYFTPAAGQGALAVITRA-DSELISSIGRITHHPSLQEVTAEKTLLRELGAGCQCPLGV 239 Query: 249 YAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 ++ L A++ +G + + RG +AE +G A+E+ Sbjct: 240 IGRATGNQLTLYAVLLTREGEMLRKVTVRGPLAEAEDIGKKAAKEM 285 >UniRef50_Q1EPC8 Porphobilinogen deaminase, chloroplast (Hydroxymethylbilane synthase) (Pre-uroporphyrinogen synthase), putative n=1 Tax=Musa acuminata RepID=Q1EPC8_MUSAC Length = 328 Score = 315 bits (808), Expect = 1e-84, Method: Composition-based stats. Identities = 126/296 (42%), Positives = 163/296 (55%), Gaps = 34/296 (11%) Query: 11 RQSPLALWQAHYVKDKLMASHPGLV----VELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66 R S LAL QA +DKL A+H L VE++ + T GD+ILD PLA +GGKGLF KE+ Sbjct: 54 RDSDLALAQARETRDKLKAAHSELAEEGAVEIIIIKTTGDMILDKPLADIGGKGLFTKEI 113 Query: 67 EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126 + ALL+ R DIAVHSMKDVP P+G L Sbjct: 114 DDALLQGRIDIAVHSMKDVPTYLPEGTILPCNLP-------------------------- 147 Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAA 186 +SLRRQ Q+ R P L + +LRGNV TRL+KL NG+ A +LA+AGLKRL + + + Sbjct: 148 -ASLRRQSQILCRYPSLKVVNLRGNVQTRLTKLKNGDVHATLLALAGLKRLNMVENVTSI 206 Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246 L E LPAV QGA+GI CR +D++ E L++LNH +T V ER T L+G C+ PI Sbjct: 207 LSMEEMLPAVAQGAIGIACRSNDNKMMEYLSSLNHEDTRSAVACEREFLTVLDGNCRTPI 266 Query: 247 GSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAP--QDAEQMGISLAEELLNNGA 299 +YA DG R L+ +PDGS++ R G D +MG EL Sbjct: 267 AAYAHRDKDGSCSFRGLLASPDGSKVYETTRIGPYSFDDMVEMGKDAGHELKAKAG 322 >UniRef50_C5CB88 Porphobilinogen deaminase n=5 Tax=Actinomycetales RepID=HEM3_MICLC Length = 377 Score = 314 bits (806), Expect = 2e-84, Method: Composition-based stats. Identities = 129/356 (36%), Positives = 179/356 (50%), Gaps = 61/356 (17%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 + LRI TR S LA Q +V + L A GL ELV + T GD + LA +GG G+F Sbjct: 2 SPLRIGTRGSALATTQTSHVAEALTARS-GLAHELVVIRTEGD-VTTGSLASLGGTGVFA 59 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 L A+L+ D AVHS+KD+P P+ L + + R D RDA + + +L LP G+ Sbjct: 60 SALRAAVLDGVVDAAVHSLKDLPAAQPETLEIAAVPARADLRDALCARDGLTLATLPEGA 119 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL----------------DNGEYDAI 167 VGT S RR QL RPDL + +RGNV TRL+++ G+ DA+ Sbjct: 120 RVGTGSPRRVAQLKALRPDLELVDIRGNVQTRLARVPGLEQHDDHAPAAVGSPRGDLDAV 179 Query: 168 ILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDS---------------RT 212 ILA AGL RLGL+ I + PE+ +PA GQGA+ +E R +D R Sbjct: 180 ILACAGLDRLGLDHVITERIDPEVMVPAPGQGALAMEIRAEDESFLGRALLDPEAPVGRL 239 Query: 213 RELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDG-----EIWLRALVGAPD 267 L ++ +T + VTAERA+ RLE GC PIG+ A + DG I + A+V A D Sbjct: 240 HAALELVDDRDTHVAVTAERALLRRLEAGCAAPIGAVARVGDGEAGAPRIEMTAMVAALD 299 Query: 268 GSQIIR-----------GERRGAPQ------------DAEQMGISLAEELLNNGAR 300 GS+++R + G P AE +G+ +AE+ + GA Sbjct: 300 GSRVLRRTSSVQLDPVPADVVGDPAAADEWLEDTLFVAAEALGVHVAEQFVAEGAD 355 >UniRef50_B6JII8 Porphobilinogen deaminase n=11 Tax=Bradyrhizobiaceae RepID=B6JII8_OLICO Length = 338 Score = 313 bits (802), Expect = 6e-84, Method: Composition-based stats. Identities = 111/323 (34%), Positives = 159/323 (49%), Gaps = 18/323 (5%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG-L 61 D +RI TR+S +AL Q + +L A+ P L VE+V T GD L +GGKG Sbjct: 11 DKAMRIGTRKSVMALAQTSEIARQLTAADPALDVEIVKFETTGDQDQTGKLLDLGGKGGA 70 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFP-QGLGLVTICEREDPRDAFVSNNYDSLDAL- 119 FV ++ A+ E R + A+HS+KD+P GL + R+ P DA V + +L L Sbjct: 71 FVAQIRDAVREGRLEAAMHSLKDMPGNEDTPGLVIGATLTRDPPTDALVVRHGVTLADLR 130 Query: 120 ---PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE------------Y 164 G +GT+++RR + P+ I RG TR+ KLDNGE Sbjct: 131 RTGGKGFKIGTNAVRRAAYVRRLFPECEIIHFRGAADTRIRKLDNGEKQRLPEGGEVGPA 190 Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224 DA+++A AGL+R+G RI P+ LPAVGQG V +EC D T LA ++ + Sbjct: 191 DALVMAQAGLERVGCADRIAHCFSPDEILPAVGQGIVAVECAASDWCTLARLAQIDDPVS 250 Query: 225 ALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAE 284 AER + L G C PI YA + ++ L+A V I RRG Sbjct: 251 RCCAAAEREVLWVLNGHCNSPIAGYAIVEGDDVLLKAAVLDEANDHFIEVTRRGPASRPR 310 Query: 285 QMGISLAEELLNNGAREILAEVY 307 ++G ++A ELL GA +++A Sbjct: 311 ELGRAVAFELLAKGAADVIARTR 333 >UniRef50_C9RPT6 Porphobilinogen deaminase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RPT6_FIBSS Length = 351 Score = 312 bits (801), Expect = 9e-84, Method: Composition-based stats. Identities = 128/346 (36%), Positives = 170/346 (49%), Gaps = 57/346 (16%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHP-------------GLVVELVPMVTRGDV 47 M D LRIATR+S LAL Q D ++A++ L ELV M T GD Sbjct: 1 MSDLKLRIATRKSALALAQTTMAADAIVAANSVIGNAADSNNARDSLTYELVSMTTEGDR 60 Query: 48 ILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDA 107 LD LA GGKG+F+KELE+ALLE RADIA+HS+KD+P E L + +REDPRDA Sbjct: 61 RLDKSLASFGGKGVFIKELEIALLEGRADIAIHSLKDMPAEVLPQFKLAAVLKREDPRDA 120 Query: 108 FVSNNYD---SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY 164 F+S LPAG+ VGT S+RR QL RPDL +RGN+ TR+ KL E Sbjct: 121 FLSRGGSAGIRFMDLPAGARVGTGSIRRVVQLKALRPDLEYVPIRGNIQTRIGKLA--EL 178 Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLD----------DSRTRE 214 D ++LA AGLKR+GL ++ E LPA GQG + IE D + + Sbjct: 179 DGVVLAAAGLKRMGLADQVTEYFSTEQMLPASGQGILAIETLNDATVQESRVTGRADLAQ 238 Query: 215 LLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDG------------------- 255 +LA +N T +AE A L GCQ P+ S+AE + Sbjct: 239 ILARVNDVATYCIASAEMAYLKALNAGCQFPVASFAEFVCEDGIENRGTCGALEENANRI 298 Query: 256 --EIWLRALVGAPDGSQIIRGERRGAPQ--------DAEQMGISLA 291 + +R + +++R E G ++ +GI LA Sbjct: 299 AQTLKIRGIYWDEKSEKLLRAEVAGNVDLNSEDCVQQSKNLGIELA 344 >UniRef50_Q6AHF1 Porphobilinogen deaminase n=5 Tax=Actinobacteria (class) RepID=HEM3_LEIXX Length = 329 Score = 310 bits (796), Expect = 3e-83, Method: Composition-based stats. Identities = 115/310 (37%), Positives = 158/310 (50%), Gaps = 15/310 (4%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LR+ TR SPLA+ Q V + + G +ELV + T GD + L+++GG G+F Sbjct: 15 LRVGTRGSPLAVAQTQAVSAAVARA-TGFDIELVTVTTHGDTSRE-SLSELGGTGVFATA 72 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L AL D+ VHS+KD+P GL L + +R D RD + + LP G+ V Sbjct: 73 LRDALRNGECDLVVHSLKDLPTAPAPGLVLGAVPKRADARDTLCARDGLRFGELPEGASV 132 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT S RR QL +RP L I +RGNV TRLS++ G+ DA++LA AGL RLG Sbjct: 133 GTGSPRRAAQLRAQRPGLDIVDIRGNVDTRLSRVSAGDLDAVVLAAAGLGRLGRLDAATD 192 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSR----TRELLAALNHHETALRVTAERAMNTRLEGG 241 A GQGA+ +E R D R LAA++H T TAERA+ LE G Sbjct: 193 FFSLSTMPTAPGQGALALEVREGDERGRGPIARALAAVDHATTCAATTAERAVLAGLEAG 252 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---------AEQMGISLAE 292 C P+G+ A + DG ++L A V PDG+ + P A +G + Sbjct: 253 CAAPVGATAMIDDGLLFLTATVYRPDGAAQLTASHAATPDSFGAAHLDEAARDVGERVVA 312 Query: 293 ELLNNGAREI 302 ELL +GA ++ Sbjct: 313 ELLASGAADL 322 >UniRef50_A3VPD5 Porphobilinogen deaminase n=1 Tax=Parvularcula bermudensis HTCC2503 RepID=A3VPD5_9PROT Length = 324 Score = 308 bits (791), Expect = 1e-82, Method: Composition-based stats. Identities = 135/286 (47%), Positives = 178/286 (62%), Gaps = 6/286 (2%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMAS------HPGLVVELVPMVTRGDVILDTPLA 54 M LRIA+R+SPLA+ QA +V+D+L + VT GD +L+ LA Sbjct: 1 MSFKPLRIASRRSPLAVAQALWVRDRLAEALGIDEVDRDAAFPHETFVTTGDRMLNPTLA 60 Query: 55 KVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD 114 +GGKGLF KE+E+ALL+ +ADIAVHSMKD+P + P GL L + REDPRDAFV+ + Sbjct: 61 DIGGKGLFTKEIEIALLDGQADIAVHSMKDMPAQMPPGLVLAAVPVREDPRDAFVTLDGR 120 Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174 LD +PAG+ +GTSS RR+ QLA RPDL + +RGNVGTRL KL GE + LA AGL Sbjct: 121 PLDQMPAGARIGTSSTRRRAQLARLRPDLALVPMRGNVGTRLQKLAAGEAEGTFLAEAGL 180 Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234 +RLG+ R AL P LPA+GQGA+ ++ R D T A +N+ TAL AERA+ Sbjct: 181 RRLGMTDVKREALSPARMLPALGQGALCVQARSGDHETLSACAHINNRPTALAAAAERAL 240 Query: 235 NTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAP 280 + L+G C+ PIG A + L + PDG +++RGER A Sbjct: 241 ISGLDGSCKTPIGGLARQTGDSLILEGQILTPDGRRVLRGERTVAI 286 >UniRef50_A8PWJ5 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8PWJ5_MALGO Length = 530 Score = 308 bits (791), Expect = 1e-82, Method: Composition-based stats. Identities = 131/394 (33%), Positives = 187/394 (47%), Gaps = 92/394 (23%) Query: 5 VLRIATRQSPLALWQAHYV------------------------------KDKLMASHPG- 33 L +++R+S LA+ QA V + L P Sbjct: 89 TLVLSSRKSELAVRQATQVQMLLDTRYGRASPVFAPGADQWPSTEVANIRAFLRTFSPDQ 148 Query: 34 -----LVVELVPMVTRGDVILDTPLAKVGGKG--LFVKELEVALLENRADIAVHSMKDVP 86 + + M T GD L +PL +GG+G ++ KELEVAL+ D VHS+KDVP Sbjct: 149 KDVRPVDFPVRTMATLGDQNLKSPLYVIGGEGRAIWTKELEVALMAGGVDAIVHSLKDVP 208 Query: 87 VEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALPAGSIVGTSSLRRQCQLAERRPDL 143 P G+ L I EREDPRDA V Y SL +P GS++GTSS+RR L P L Sbjct: 209 TTMPDGVELAAILEREDPRDALVVKENLPYKSLQEMPQGSVIGTSSVRRVSLLRRAYPHL 268 Query: 144 IIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAV 201 + +RGN+ TRL+KLD +G Y A++LA AGLKR+ LE RI A + + L AVGQG++ Sbjct: 269 MFSDVRGNINTRLAKLDAADGPYTALVLAAAGLKRMDLEHRITAYVSEPVMLHAVGQGSL 328 Query: 202 GIECR-------LDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELI- 253 IE R D R R ++ ++++ R AERA+ R+EGGC +P+G Sbjct: 329 AIEVRTPRGESAERDERIRRMIRSISNWRATWRCVAERALMHRMEGGCSIPLGVSTRFED 388 Query: 254 -------------------------------------DGEIWLRALVGAPDGSQIIRGER 276 + + A++ + DG+++ + Sbjct: 389 HADIEGLLNERNETPSEMASAGISRPDIRIAHEPPPQGSFLTMAAVIVSLDGTRMCKHSH 448 Query: 277 R---GAPQDAEQMGISLAEELL-NNGAREILAEV 306 + +DAEQ+GI +AEEL + AR ILAEV Sbjct: 449 TQLCRSEKDAEQLGILVAEELEHHQNARAILAEV 482 >UniRef50_C5EV71 Pyruvate ferredoxin/flavodoxin oxidoreductase n=3 Tax=Clostridiales RepID=C5EV71_9FIRM Length = 301 Score = 308 bits (789), Expect = 2e-82, Method: Composition-based stats. Identities = 119/305 (39%), Positives = 165/305 (54%), Gaps = 15/305 (4%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + N++RI TR+S LAL Q H + D L + P + VELV T GD ILD PL + GGKG+ Sbjct: 1 MSNIIRIGTRKSALALIQTHLIADGLKRAWPDIEVELVTKETLGDKILDKPLQEFGGKGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 FV E E A+ E D+AVHS KD+P+E +GL + + R DPRD V+ D Sbjct: 61 FVSEFEQAMKEGAIDLAVHSAKDLPMELGEGLVIAAVSGRGDPRDVLVTMKGSPKDR--E 118 Query: 122 GSIVGTSSLRRQCQLAERR-------PDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174 ++GTSS RRQ + E R L +LRGNV TRL KL+ G YD IILA AGL Sbjct: 119 HIVIGTSSPRRQLEAVEYRGQLWPGAASLTCATLRGNVHTRLRKLEEGLYDGIILAAAGL 178 Query: 175 KRLGLESRIRA---ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231 +RL L L P + +PA GQG + +E R R L A++ E L +T E Sbjct: 179 ERLDLLGNPSYDFKYLDPTVFIPAGGQGIMAVEAREGSDAAR-LCQAIDSREGRLCLTLE 237 Query: 232 RAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDG-SQIIRGERRGAPQDAEQMGISL 290 R + L+ GC PIG Y+ ++DG++ + + PD ++ I E ++ E + + Sbjct: 238 RMVLKLLDAGCHEPIGIYSNIMDGKMEVWG-ISRPDRVTRRISLEGAVTEKELEALALQA 296 Query: 291 AEELL 295 L+ Sbjct: 297 GRGLM 301 >UniRef50_B2ULP1 Porphobilinogen deaminase n=1 Tax=Akkermansia muciniphila ATCC BAA-835 RepID=B2ULP1_AKKM8 Length = 325 Score = 306 bits (784), Expect = 8e-82, Method: Composition-based stats. Identities = 121/317 (38%), Positives = 157/317 (49%), Gaps = 21/317 (6%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG---- 57 N L I TR S LAL QA V+ L +P L V + T GD D PLA V Sbjct: 3 SKNTLIIGTRGSALALAQADMVRAALSLRYPELDVRCEIIHTIGDRRTDVPLADVARVSG 62 Query: 58 --GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS 115 KG+F+KELE AL + R D+AVHS+KDVP E G L + R D ++ D Sbjct: 63 MVDKGIFIKELETALRDGRIDVAVHSLKDVPSELAAGFTLAAVLPRAAVEDVLITKEPDW 122 Query: 116 LDALPAGSIVGTSSLRRQCQLAERR-PDLIIRSLRGNVGTRLSKL-DNGEYDAIILAVAG 173 + + T S+RR+ L +LRGNV TRL KL ++ +DA+ILA AG Sbjct: 123 NGS----GTLATGSVRRRLMARTYWGSGLRFENLRGNVPTRLGKLVEHPGWDAVILARAG 178 Query: 174 LKRLGLESRIR---------AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224 L+RLGL + LP E+ +PAVGQG VG+ECR D T E+L +N E+ Sbjct: 179 LERLGLYAPETLVEGRKLYMRPLPVEVFIPAVGQGIVGMECRSSDRETAEMLEGINDPES 238 Query: 225 ALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAE 284 AERA RL C P+G YA E+ LRA P + RG + E Sbjct: 239 FACALAERAFLVRLGANCSTPVGVYAHPDGEELVLRAAYYVPGREEPFAVVIRGDRKAPE 298 Query: 285 QMGISLAEELLNNGARE 301 +G+ EEL +G R+ Sbjct: 299 ALGLRAFEELGLSGWRK 315 >UniRef50_A2SQU4 Uroporphyrin-III C-methyltransferase n=11 Tax=Euryarchaeota RepID=A2SQU4_METLZ Length = 542 Score = 305 bits (783), Expect = 1e-81, Method: Composition-based stats. Identities = 119/308 (38%), Positives = 165/308 (53%), Gaps = 22/308 (7%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 + +RI TR S LAL Q V L + G+ E V + T GD + D L ++GG G+FV Sbjct: 2 SKIRIGTRGSKLALAQTKKVIGLLAEN--GIDAEYVIIKTTGDKVTDRGLHQIGGFGMFV 59 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 +EL+ A+L D AVHSMKD+P E P+GL V + +R+ P D V N ++ L Sbjct: 60 RELDNAILRGEIDCAVHSMKDIPAERPKGLLTVAVLKRDPPYDFLVMN--GKVEDL---M 114 Query: 124 IVGTSSLRRQCQLAERR---PDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 ++GTSSLRR+ QL P + + LRGN+ TRL KLD+G YD I++A AGL RL + Sbjct: 115 VIGTSSLRRKAQLLRYFHNCPAVRVEMLRGNLDTRLGKLDDGLYDGIMVAEAGLMRLDYK 174 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R L P++ +PA QG + I R D R A LN ++AL ER + ++ G Sbjct: 175 -RNGVRLSPDMFVPAANQGTIAIVSR-DTPELRAAFAPLNDPQSALDCAIERIVMEQVGG 232 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-GAPQDAEQMGISLAEELLNNGA 299 GC P+G + E L A V + DG++ R G + A GI L N GA Sbjct: 233 GCFTPMGIFCENQ----HLTAEVLSLDGTRAERITAEIGDLEGARVAGI----RLKNVGA 284 Query: 300 REILAEVY 307 E++AE Sbjct: 285 -ELIAEAK 291 >UniRef50_A6LKX0 Porphobilinogen deaminase n=1 Tax=Thermosipho melanesiensis BI429 RepID=A6LKX0_THEM4 Length = 279 Score = 305 bits (781), Expect = 2e-81, Method: Composition-based stats. Identities = 94/247 (38%), Positives = 141/247 (57%), Gaps = 6/247 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +R+ TR+S LAL Q V +KL P + E+ P+VT+GD L TP+ K+GGKG+FV Sbjct: 2 KIRVGTRKSKLALIQTQLVVNKLKELLPNIDFEITPVVTKGDR-LKTPIDKIGGKGVFVS 60 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 ++E +L+++ DIA+HSMKD+P + P L L ++ +RE P D F+ + L G+ Sbjct: 61 DIEKLILDDKLDIAIHSMKDLPSKIPDKLFLTSVLKRECPNDVFIGKE--NFFNLKKGAK 118 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSS RR Q+ RPD+ I +RGNV TR+ K+ GE D I++A AG+ RLGL+ +I Sbjct: 119 IGTSSKRRALQINMLRPDIEIVPIRGNVDTRIKKI--GELDGIVIAAAGVIRLGLKDKIT 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSR-TRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 E +PA QG + +E + E+ + +T + ER + + L C Sbjct: 177 NLFEFEKIVPAPCQGILALEFSEKFLKPFEEIKDVIVDPKTEVETQIERKILSLLNFDCN 236 Query: 244 VPIGSYA 250 P G Y Sbjct: 237 TPFGFYC 243 >UniRef50_Q6L2G8 Probable porphobilinogen deaminase n=1 Tax=Picrophilus torridus RepID=HEM3_PICTO Length = 282 Score = 304 bits (779), Expect = 3e-81, Method: Composition-based stats. Identities = 105/255 (41%), Positives = 151/255 (59%), Gaps = 8/255 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LA+ QA VKD+L + G+ E+ ++GD+ LD+PL +GG G+FV + Sbjct: 3 IRIGTRSSKLAMIQAMMVKDRLDSL--GIETEVKGFTSKGDINLDSPLYSIGGTGVFVDD 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L +L+N DIAVHS KD+P L + + +R+DPRD +S + SL+ L A S++ Sbjct: 61 LNRMILKNEIDIAVHSAKDIPSFIDDSLEISAVLKRDDPRDVLISQH--SLNDLEASSVI 118 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR +L R D++I+ LRGN+ TRL KLDNG+YD II+A A R+ +R Sbjct: 119 GTSSLRRIKELKTLRNDILIKDLRGNIDTRLKKLDNGDYDGIIMAKAAYDRM-RINRRHF 177 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 L + +PA QG + I DS ++L +N ET + AER + + L GC P Sbjct: 178 ILNYDDFVPAPNQGIIAI-ISKKDSEINDVLKKINDDETYNDMKAERLILSGLNLGCSKP 236 Query: 246 IGSYAELIDGEIWLR 260 +G YA I++R Sbjct: 237 VGIYAH--KNRIFMR 249 >UniRef50_C7DH16 Porphobilinogen deaminase n=1 Tax=Candidatus Micrarchaeum acidiphilum ARMAN-2 RepID=C7DH16_9EURY Length = 301 Score = 303 bits (777), Expect = 5e-81, Method: Composition-based stats. Identities = 108/306 (35%), Positives = 169/306 (55%), Gaps = 7/306 (2%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M ++ + I TR S LA+ QA V++KL A P + +V + T + + D A+ K Sbjct: 1 MSESEITIGTRGSELAVAQAEIVRNKLAAIEPRISFRIVKIKTLNEKV-DRSKART-EKD 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 ++ KE++ A+LE R DIAVHS+KD+ + + + + +R+DPRD F+ N + L Sbjct: 59 IYTKEIDEAILERRIDIAVHSLKDLKFNMDENMQIGAVPDRDDPRDVFIGNTETEFEHLG 118 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 ++VGTSS+RR+ QL P +I L GN+ TRLSKL++GE+ I++A AG+KRLG Sbjct: 119 TDALVGTSSIRRRVQLTRINPKPMISDLHGNIDTRLSKLNSGEFSGIVIAAAGVKRLGKA 178 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 R+ +PA+GQGA+ + D+S ELL +++ + + V E Sbjct: 179 VRM-QYFDERDVVPAIGQGAIAVTVHKDNSAAAELLKRIDNMKARVEVGEEIEFGKAFGT 237 Query: 241 GCQVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299 GC +PIG+ A+ L G+I + V G +++GE P A G SLAE L+ GA Sbjct: 238 GCNLPIGANAKMLESGKIGIVGFVSDLAGKTLVKGETETGPGHA---GKSLAELLIKKGA 294 Query: 300 REILAE 305 ++ Sbjct: 295 GNLIER 300 >UniRef50_C6V4N6 Porphobilinogen deaminase n=2 Tax=Neorickettsia RepID=C6V4N6_NEORI Length = 286 Score = 303 bits (777), Expect = 5e-81, Method: Composition-based stats. Identities = 113/292 (38%), Positives = 163/292 (55%), Gaps = 9/292 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 L++ R S LAL QA V+ L + LV + T GD++ D PL +VGGK LF+KE Sbjct: 4 LKVGARCSTLALAQARLVERALAPYCERID--LVGVRTSGDILSDIPLTEVGGKALFLKE 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 LE LL DIAVHSMKDVP + L +V + +R P D FVS Y ++ +LP+G+++ Sbjct: 62 LEEKLLTGEIDIAVHSMKDVPAFYHDDLEVVPVLKRAIPNDVFVSFRYPNMLSLPSGAVI 121 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GT + RR QL +R + LRGN+ TR+ K N D IILA GL+RLGL I Sbjct: 122 GTCAPRRVVQLNQRF---RVIPLRGNIATRVEKAKN--LDGIILAFCGLERLGLCKMISE 176 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245 + ++ LP V QGA+ +E R D REL+ ++ ET + TAERA + G C+ Sbjct: 177 VIHEDVMLPGVAQGALCVEFRKKDHFLRELILNISDRETIICTTAERAFLEEINGDCKTA 236 Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 +G+ A + + ++ ++G + R G+ +A+Q+G S A LL Sbjct: 237 LGALAVVKNNTLYFTGMLGKDNRPCYFRTS--GSCLNAKQIGRSAALALLRM 286 >UniRef50_B3LB83 Porphobilinogen deaminase, putative n=1 Tax=Plasmodium knowlesi strain H RepID=B3LB83_PLAKH Length = 449 Score = 303 bits (776), Expect = 7e-81, Method: Composition-based stats. Identities = 102/382 (26%), Positives = 168/382 (43%), Gaps = 73/382 (19%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHP----GLVVELVPMVTRGDVILDTPLAKVGGK 59 + I TR SPLA+ Q+ V+ KL A + + L + T GD ILD + GGK Sbjct: 65 KEIIIGTRDSPLAIKQSEKVRTKLEAYFKKVNKNVKITLKSIKTMGDNILDQKVDLFGGK 124 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 G+F KEL+ L++ + I VHS+KDVP+E P+ + L +R+ DAF+S Y +L+ + Sbjct: 125 GIFTKELDEELIKGKVHICVHSLKDVPMELPEQVQLSCFLKRDTINDAFLSVKYGTLEDM 184 Query: 120 ---------------PAGS------------------------IVGTSSLRRQCQLAERR 140 P G +GTSSLRR Q+ + Sbjct: 185 NKMKMANKMEEGSYQPKGMSQRVINQNVKRDNYEGDHYDNFIPTIGTSSLRRSSQIKYKY 244 Query: 141 PDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL----------------------- 177 ++ ++++RGN+ TR++KL NG+YDAII+A GL+RL Sbjct: 245 KNVAVKNMRGNINTRIAKLCNGQYDAIIIAKCGLERLTTKKGIRNIIGGKNKVTPKNFLI 304 Query: 178 -------GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTA 230 L S + PA+ QG + + D ++L +N + + Sbjct: 305 NYNNTEINLTSLHIQQINKRTIYPALCQGIIAVSSHKSDKYISDVLKNINDEKAQIMANI 364 Query: 231 ERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISL 290 ER+ ++EG C +PIG YA++++GEI A++ G + G + ++ + Sbjct: 365 ERSFLYQIEGNCMMPIGGYAKIVNGEIVFNAVINDIHGREKYHVREVGKVESYNEIAVMA 424 Query: 291 AEELLNNGAREILAEVYNGDAP 312 A ++ ++ A Sbjct: 425 ATKMKEKIGTHRFNKIREEAAQ 446 >UniRef50_D1B7N1 Porphobilinogen deaminase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B7N1_THEAS Length = 307 Score = 303 bits (776), Expect = 7e-81, Method: Composition-based stats. Identities = 114/298 (38%), Positives = 159/298 (53%), Gaps = 12/298 (4%) Query: 10 TRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVA 69 TR SPLA+ QA KD++ + G V L+ + T GD LA GG G FVK LE Sbjct: 8 TRSSPLAMAQARMWKDRIESL--GHSVRLLDVSTHGDRDRRRHLACFGGFGAFVKALEDR 65 Query: 70 LLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSS 129 LL + AVHS+KDVP P GL + + ER D V+ SL+ LP+G+++GTSS Sbjct: 66 LLSGQGHGAVHSLKDVPSVQPDGLVIAGVLERGPRGDVLVTREGLSLEELPSGAVIGTSS 125 Query: 130 LRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPP 189 +RR Q+ R DL + RGNV +RL KL+ G + I+LA AGL+RLG IRA + Sbjct: 126 IRRAAQVRMLRGDLNVECCRGNVHSRLRKLEQGLFHGIVLARAGLERLG----IRAPMAE 181 Query: 190 EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSY 249 + + GQGAV +E R S L A L H T L V AER+ GC P+ + Sbjct: 182 LPFITSPGQGAVALEAREG-SELHLLGARLTHRSTWLEVLAERSFLKAFGMGCSAPVAAS 240 Query: 250 AELIDGEIWLRALVGAPDGSQIIRGERRGAP---QDAEQMGISLAEELLNNGAREILA 304 A + + L+ V +P+G+ E P +DA +G + E+ +G+ E+L+ Sbjct: 241 AVMDRDTLTLKVQVLSPNGTSAAEAEVSCVPWGEEDAYALGEAAFREI--SGSPEVLS 296 >UniRef50_Q5KKQ0 Hydroxymethylbilane synthase, putative n=2 Tax=Filobasidiella neoformans RepID=Q5KKQ0_CRYNE Length = 481 Score = 302 bits (773), Expect = 2e-80, Method: Composition-based stats. Identities = 105/289 (36%), Positives = 141/289 (48%), Gaps = 37/289 (12%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPG-------------------------LVVE 37 N + TR+S LAL Q +V D L H G Sbjct: 30 TNTFILGTRKSNLALVQTGHVADDLRRLHSGAGSKFGETREEGDDAEQGDVPFVHPYTFS 89 Query: 38 LVPMVTRGDVILDTPLAKV-------GGKGLFVKELEVALLENRADIAVHSMKDVPVEFP 90 + M T GD TPL + K L+ ELE L+ D+ VHS+KDVP Sbjct: 90 IESMTTVGDRNQTTPLHLLSPYSSTQPAKSLWTDELEARLINGHFDMLVHSLKDVPTVLK 149 Query: 91 QGLGLVTICEREDPRDAFVSNNY---DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRS 147 G + + +R DPRDA V L+ LP G++VGT S+RR QL P+L+ Sbjct: 150 DGCEIGCMAKRHDPRDALVVKQGLPYKRLEDLPDGAVVGTGSVRRVAQLKRAFPNLVFED 209 Query: 148 LRGNVGTRLSKLDNGE--YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIEC 205 +RGN+ TR +KLDN + + A+ILA++GL+RLG+ R + L + AVGQGA+ IE Sbjct: 210 MRGNLNTRFNKLDNPQSPFSALILAMSGLERLGMAHRATSPLSSPTLMHAVGQGALAIEI 269 Query: 206 RLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID 254 R D R R L L H +T AER LEGGC VP+G +EL++ Sbjct: 270 RSTDPRVRNCLRGLGHWQTEWSCGAERGCLRVLEGGCSVPVGVESELVE 318 Score = 48.2 bits (114), Expect = 4e-04, Method: Composition-based stats. Identities = 17/57 (29%), Positives = 26/57 (45%), Gaps = 4/57 (7%) Query: 256 EIWLRALVGAPDGSQIIRGE----RRGAPQDAEQMGISLAEELLNNGAREILAEVYN 308 ++ L + V + DGS+ + + + AEQ G A L GA EIL E+ Sbjct: 386 KLTLHSCVTSTDGSKHVLFTPPPVLVRSYRQAEQFGEECARRLRGMGAGEILDEINK 442 >UniRef50_Q0ATQ1 Porphobilinogen deaminase n=3 Tax=Alphaproteobacteria RepID=Q0ATQ1_MARMM Length = 321 Score = 302 bits (773), Expect = 2e-80, Method: Composition-based stats. Identities = 129/305 (42%), Positives = 165/305 (54%), Gaps = 14/305 (4%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASH------PGLVVELVPMVTRGDVILDTPLAKV 56 L IATR+SPLAL QA V+ KL A ++ +V+ GD I D L + Sbjct: 5 SRPLAIATRRSPLALVQARDVQAKLAAQCGLSGEDAERCFPILGLVSTGDRIQDRTLIEA 64 Query: 57 GGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS- 115 GGKGLF KE++ A L+ RA AVHSMKDVP P G+ L + EREDPRD ++ + ++ Sbjct: 65 GGKGLFTKEIDEAQLDGRAAFAVHSMKDVPTVLPDGIVLGALLEREDPRDMLIARDGETR 124 Query: 116 LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLK 175 L LP G +GT+SLRRQ QL +RPDL + LRGNV TRL KL +G A LA AGL Sbjct: 125 LADLPEGVTIGTASLRRQAQLLHKRPDLHVVPLRGNVDTRLGKLADGGIHATFLARAGLN 184 Query: 176 RLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235 RLG +R L + LPA QGAVG+ R D +A L+H +T L V AERA Sbjct: 185 RLGRAEALRDPLEADEMLPAAAQGAVGVAIRDGDEEAASYVAGLHHRDTELAVLAERAFL 244 Query: 236 TRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-----GAPQDAEQMGISL 290 L+G C+ PI ++ + + V PDG Q R + R P A Q G L Sbjct: 245 FELDGSCRTPIAAH--VNKVSMDFIGEVLTPDGQQSWRRQIRFDMTHATPDSARQAGQDL 302 Query: 291 AEELL 295 + Sbjct: 303 GRAVR 307 >UniRef50_B5GJG2 Porphobilinogen deaminase n=3 Tax=Streptomyces RepID=B5GJG2_9ACTO Length = 335 Score = 300 bits (770), Expect = 3e-80, Method: Composition-based stats. Identities = 113/309 (36%), Positives = 153/309 (49%), Gaps = 12/309 (3%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTP----LAKVGGK 59 + + +R S LA Q + ++ PG+ + GD TP + + G Sbjct: 31 RTVTVGSRGSALARAQVREMVERWEREVPGVRFVRRVITEAGDADRSTPTVAGVTRRAGV 90 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTIC-EREDPRDAFVSNNYDSLDA 118 F E AL+ D+ VH +KD+P G L+ RED RDA +L Sbjct: 91 SAFSSRQEAALVRREVDVVVHCLKDLPTTPAPGTALLRTPGPREDARDALC---GATLAG 147 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 LP G+ VGT S RR QL RPDL + +RGNV RL++L DA++LA AGL RLG Sbjct: 148 LPRGARVGTGSTRRVAQLLALRPDLEVIPVRGNVPARLARLRT--LDAVVLAAAGLHRLG 205 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 L I L PE PA GQGA+ I+ R S LLAA T V AER + L Sbjct: 206 LTEEITEYLDPEAYPPAPGQGALAIQVREG-SGAARLLAASGDPATDTEVRAERVLLAEL 264 Query: 239 EGGCQVPIGSY-AELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 GGC VP+G++ + G + L A V APDG + I +G + +++ +++AE LL Sbjct: 265 HGGCSVPLGTWTSRPSPGTLRLHAAVTAPDGGRQITATAQGPASEPDKLALTVAERLLAG 324 Query: 298 GAREILAEV 306 GA ILAE Sbjct: 325 GAARILAEA 333 >UniRef50_C7M2H5 Porphobilinogen deaminase n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7M2H5_ACIFD Length = 291 Score = 300 bits (768), Expect = 5e-80, Method: Composition-based stats. Identities = 123/299 (41%), Positives = 171/299 (57%), Gaps = 14/299 (4%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +RIATR+S LA WQA V ++L ELV + T GD + LA++GG+G+FVK Sbjct: 3 PVRIATRRSALARWQASLVGERLGR------YELVEVHTAGDRDQASSLAEIGGQGVFVK 56 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E++ A++ ADIAVHS KD+P L L + ER D RDA V L+ L G+ Sbjct: 57 EVQAAVVRGEADIAVHSAKDLPTAAGP-LLLAAVLERADARDAIV---GARLEELAIGAR 112 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGTS+ RR QL RPDL + S+RGN+ TRL ++ GE DAI++AVA L+RLGLE Sbjct: 113 VGTSAPRRAAQLRLLRPDLEVVSIRGNIATRLGRV--GELDAIVMAVAALERLGLEEPPW 170 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 LP E+ P GQGA+ +EC D E L +L+ + + AERA+ GC + Sbjct: 171 WPLPEEVLCPQAGQGAIAVECAPDADGLIERLRSLDDDRSRREIEAERAVLAAFGTGCAL 230 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 P+G+ A + LRA+ PDG++ + ER G D +G ++AE L GA ++ Sbjct: 231 PLGARAHADGSSLRLRAVAVDPDGTRQLEVEREGV--DPATLGATVAEVLRRLGADALV 287 >UniRef50_Q1AUK3 Porphobilinogen deaminase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=HEM3_RUBXD Length = 305 Score = 299 bits (767), Expect = 8e-80, Method: Composition-based stats. Identities = 134/306 (43%), Positives = 175/306 (57%), Gaps = 5/306 (1%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + L + TR SPLAL QA L A+ G VEL + T D D PL+ + + + Sbjct: 1 MAGRLVLGTRGSPLALAQAEACAAGLRAA--GFAVELRRIRTTSDRRPDDPLSVIDQRDV 58 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F ++L+ ALL D+AVHSMKDVP E P+G+ L + R DP DA VS +D LP Sbjct: 59 FTRQLDEALLAGEVDLAVHSMKDVPTEVPEGIVLAAVAGRADPSDALVSEGGWGVDGLPE 118 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 G+ V TSSLRR+ QL RRPDL + +RGNV TR+ K+ G +A++LA AGL RLGLE Sbjct: 119 GARVATSSLRRRAQLLHRRPDLRVVEIRGNVDTRIRKMRAGAAEAVVLARAGLVRLGLE- 177 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 A +P ++ LPAVGQGA+ + R D R E+ ALN V AERA+ LEGG Sbjct: 178 VPHAVIPHDVLLPAVGQGALAVAVRRGDPRLEEIRRALNDPAAEREVAAERALLRALEGG 237 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 C+VP+G+ A + LR +V +PDG+ + GE RG + LA LL GA Sbjct: 238 CRVPVGARAVAGGRGVLLRGVVVSPDGAALCGGEERGEEPEEVG--RRLAARLLERGAAG 295 Query: 302 ILAEVY 307 IL V Sbjct: 296 ILGFVR 301 >UniRef50_A4YD92 Probable porphobilinogen deaminase n=1 Tax=Metallosphaera sedula DSM 5348 RepID=HEM3_METS5 Length = 290 Score = 298 bits (764), Expect = 2e-79, Method: Composition-based stats. Identities = 110/297 (37%), Positives = 153/297 (51%), Gaps = 14/297 (4%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +RIA R S L+L Q V L A G E + + T+ D+ + PL ++G KG+F K Sbjct: 2 KIRIAARGSKLSLKQVEIVTTYLQAK--GYETEFIEIKTKADLFGNKPLHEIG-KGVFEK 58 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E+ A+L+ RADIAVHSMKD+ E P GL L+ +RE+P D VS +L+ LP S Sbjct: 59 EVNEAVLQGRADIAVHSMKDMSSELPPGLELLATPKRENPVDVLVSE--LNLEELPEKSR 116 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GT SLRR L RPDL++ ++RGNV TRL K + EYD IILA AGL+RLG+E + R Sbjct: 117 IGTGSLRRANFLKVVRPDLVVENIRGNVDTRLRKYRDHEYDGIILAEAGLRRLGVEVK-R 175 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L E P QG + + + L LN T AE+ + GGC Sbjct: 176 FPLDVESFTPEPNQGIIAVV---GSPKFLGLFQELNDTGTMKEALAEKETVKVVGGGCHS 232 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRG---ERRGAPQDAEQMGISLAEELLNNG 298 P+G L D L + +G + + R Q+G +L + + + G Sbjct: 233 PLGVLFRLEDDV--LHGIASYSNGVKRVTVKLSTRESPQIAGNQLGKALVKAMKDEG 287 >UniRef50_C7R376 Porphobilinogen deaminase n=1 Tax=Jonesia denitrificans DSM 20603 RepID=C7R376_JONDD Length = 344 Score = 298 bits (763), Expect = 2e-79, Method: Composition-based stats. Identities = 126/344 (36%), Positives = 172/344 (50%), Gaps = 47/344 (13%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LR+ TR S LA Q+ L+A G+ V+L + T GD +L LA +GG G+FV Sbjct: 4 LRLGTRASALATAQSRATA-ALIAQATGVTVDLTHIRTDGD-VLTGSLATMGGAGVFVTA 61 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 + ALL DIAVHS+KD+P +G ++ + ERE+P+DA S + +SL LP G++V Sbjct: 62 IRQALLAGDIDIAVHSLKDLPTTPHEGTTII-VPERENPQDALCSRHGESLAHLPHGALV 120 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD---------NGEYDAIILAVAGLKR 176 GT S RR QL RPDL I +RGNV TRL+++ + DA++LA AGL+R Sbjct: 121 GTGSPRRAAQLLVARPDLRIVDIRGNVDTRLARVGLSTADKPHIRNDLDAVVLAAAGLRR 180 Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSR----TRELLAALNHHETALRVTAER 232 LG I LPP LPA GQGA+ IE R D + + L+H TA V AER Sbjct: 181 LGRAHVISELLPPTSMLPAPGQGALAIEVRHDMADHHPSILAGIRTLHHQPTAYAVAAER 240 Query: 233 AMNTRLEGGCQVPIGSYAEL-----------IDGEIWLRALVGAPDGSQII--------- 272 A+ LE GC P+G+ A + +D + A P + I Sbjct: 241 AVLRHLEAGCAAPVGALATMHNTTLTLTATALDPRLTPTAHTPTPSTTTDINAAPTPMTA 300 Query: 273 -----------RGERRGAPQDAEQMGISLAEELLNNGAREILAE 305 + DA + GI+LA LL +GA E L + Sbjct: 301 PADARPPIRLTHTHTVTSENDATEAGITLATTLLTHGAAEFLRD 344 >UniRef50_D1JID7 Porphobilinogen deaminase n=1 Tax=uncultured archaeon RepID=D1JID7_9ARCH Length = 290 Score = 297 bits (761), Expect = 3e-79, Method: Composition-based stats. Identities = 97/295 (32%), Positives = 153/295 (51%), Gaps = 11/295 (3%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 + + TR S LAL Q V ++L G+ E+ + + GDV+ D L ++ G+FVK+ Sbjct: 1 MIVGTRGSNLALVQTKKVCERLSEL--GVECEIKTVQSLGDVMTDRGLYEMPTIGVFVKK 58 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 L++ LL+ + DIAVHSMKD+P E + L + R+ P DA VS LD +P G+++ Sbjct: 59 LDMMLLDAKIDIAVHSMKDMPSEREEELDTSAVLPRDSPYDALVSR--YRLDDMPEGAVI 116 Query: 126 GTSSLRRQCQLAER----RPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 GTSS+RR+ Q + I+ +RGNV TR++K GEYD++ILA AG +RL L+ Sbjct: 117 GTSSVRRRYQFLNYVGERGVKVTIKDIRGNVDTRIAKFRRGEYDSVILAEAGFERLKLDI 176 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 L + +P+ QG + + R E+L ++ ET + E + + GG Sbjct: 177 EY-ERLDRDPFVPSPRQGIIAVVARRGSKE-SEILKQIDDSETRIEAEVEEEVLKVIGGG 234 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 C +P+G +A G + L V A D + G E+ LA++ + Sbjct: 235 CSLPVGVHATAKGGSVELAVYVAASDVRYKLEKVVLGKDYYMEET-RELAQKFKS 288 >UniRef50_C4JRY9 Porphobilinogen deaminase n=1 Tax=Uncinocarpus reesii 1704 RepID=C4JRY9_UNCRE Length = 287 Score = 296 bits (758), Expect = 8e-79, Method: Composition-based stats. Identities = 107/318 (33%), Positives = 154/318 (48%), Gaps = 58/318 (18%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 I TR+SPLAL Q V+ L ++P Sbjct: 7 KTYTIGTRKSPLALVQTDLVRRALQTAYPN------------------------------ 36 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLDALP 120 D+ VH VP + P L + RE+PRD V +L LP Sbjct: 37 -----------CDLKVHG--HVPTQIPDACVLGAMMPRENPRDVLVIKKGLPWMTLAELP 83 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLKRLG 178 AGS+VGTSS+RR QLA P L+++ +RGN+ TRL+KLD +G + +I+A AGL R G Sbjct: 84 AGSVVGTSSVRRTAQLARHYPHLVVQDIRGNIDTRLAKLDAEDGPFTCLIMAAAGLLRTG 143 Query: 179 LESRIRAALPPE--ISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236 E+R+ L + L AVGQGA+GIE R DD ++++ + T AER + Sbjct: 144 HENRVTQYLDSKNGKMLHAVGQGALGIEVRTDDEVMKDMVNKIGDMPTTYACMAERNLLR 203 Query: 237 RLEGGCQVPIGSYAELIDGE-----IWLRALVGAPDGSQIIRGERRGA---PQDAEQMGI 288 +EGGC P+G E I + + LRA+V + DG + + E+ G ++AE G Sbjct: 204 TVEGGCSAPLGVETEWIQDDNGKSLLRLRAIVVSVDGKEAVELEKDGDVESIEEAEAFGK 263 Query: 289 SLAEELLNNGAREILAEV 306 +A EL++ GA +IL E+ Sbjct: 264 QVALELIDKGAGKILEEI 281 >UniRef50_A9HK97 Porphobilinogen deaminase n=12 Tax=Acetobacteraceae RepID=A9HK97_GLUDA Length = 367 Score = 295 bits (757), Expect = 1e-78, Method: Composition-based stats. Identities = 132/312 (42%), Positives = 166/312 (53%), Gaps = 21/312 (6%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLV----VELVPMVTRGDVILDTPLAKVGGKG 60 LR+ TR SPLAL Q L P L + + T GD + + LA++GGKG Sbjct: 46 PLRVGTRASPLALVQTRAFLTMLTRFCPVLRDMGAFQEHQINTTGDQVQNRRLAEIGGKG 105 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD------ 114 LF KE+ AL + R D AVHS+KD+ P GL L RED RDA + Sbjct: 106 LFAKEIHDALSDGRIDFAVHSLKDLETTLPPGLVLACTLRREDARDALILGPGAGGRHDA 165 Query: 115 -----SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIIL 169 ALP ++VG +S+RRQ Q+ RPDL LRGNV TRL KL + DA +L Sbjct: 166 ADAADPYAALPRNALVGCASVRRQAQMLHVRPDLRFGLLRGNVQTRLDKLAARQCDATLL 225 Query: 170 AVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVT 229 A+AGL+RLG+E R L PEI +PA GQG VG+ R D RELLAA+ +E T Sbjct: 226 ALAGLRRLGMEDRADIVLDPEIMVPAAGQGIVGVTVRESDVELRELLAAIEDYEARAVAT 285 Query: 230 AERAMNTRLEGGCQVPIGSYAELIDG------EIWLRALVGAPDGSQIIRGERRGAPQDA 283 AERA+ L+G C+ PIG YA L+ G + L LV DGS ++R G DA Sbjct: 286 AERALLAELDGSCRTPIGGYARLVPGLAGAEASLRLTGLVAREDGSFLLRRTVTGLRADA 345 Query: 284 EQMGISLAEELL 295 E+MG L L Sbjct: 346 EEMGRELGRSLR 357 >UniRef50_B5JN62 Porphobilinogen deaminase n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JN62_9BACT Length = 291 Score = 295 bits (757), Expect = 1e-78, Method: Composition-based stats. Identities = 112/294 (38%), Positives = 143/294 (48%), Gaps = 16/294 (5%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 IATR+SPLA+ Q H K+ P V + MVT GD + L K GGKGLF Sbjct: 6 REYVIATRKSPLAMAQTHLAKELFQRGMPDAVFRIEKMVTTGDKRQEWSLEKQGGKGLFT 65 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE ALLE RAD AVHS KD+P E P+GL L R+ D + + L Sbjct: 66 KELEDALLEGRADFAVHSAKDLPSEMPKGLALAGFLPRQTCEDVLILRDGVESPKL---- 121 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG---LE 180 + T S RR+ QL P +RGNV TRL+K+ G+ DA +LA AGL RLG E Sbjct: 122 -IATGSPRRRIQLRYLFPKAEFTEIRGNVDTRLTKIARGDADATVLASAGLNRLGIESWE 180 Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240 L + +PAVGQ AV I+CR +D T A ETA+ V ER+ L G Sbjct: 181 GVTFRKLTLDECVPAVGQAAVAIQCREEDVDT---FRAHLDEETAIAVNLERSFLEELGG 237 Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 GCQV + G + + G ++ + EQ+ L E+L Sbjct: 238 GCQVAFAV--NYVGGRLRI---YHKQCGKEVRDLPQEYVATHYEQIAAKLIEQL 286 >UniRef50_Q2FTK7 Hydroxymethylbilane synthase n=3 Tax=Methanomicrobiales RepID=Q2FTK7_METHJ Length = 295 Score = 293 bits (752), Expect = 4e-78, Method: Composition-based stats. Identities = 111/306 (36%), Positives = 163/306 (53%), Gaps = 19/306 (6%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LR+ TR S LA QA V L G+ ELV + T GD PL ++GG+G+FV+ Sbjct: 2 PLRVGTRASELAKAQAVKVCTMLEDL--GVDTELVFISTAGDEQTGVPLHEIGGQGVFVR 59 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L+ AL++N+ D+AVHSMKD+P E P GL I R+ P D V+++ L + Sbjct: 60 ALDDALVQNKIDLAVHSMKDIPAERPYGLVTSAILARDSPCDYIVTDH-----ELDEITT 114 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSS RR Q P IR LRGNV TRLSKL +GEYDAI+LA AGL+RL + Sbjct: 115 LGTSSTRRTAQCRRNLPWADIRPLRGNVNTRLSKLQSGEYDAIMLAKAGLERLSMTLDGY 174 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L P + +P+ QG + + R D ++++ ++ +T + ER + + GGC Sbjct: 175 Q-LDPRVHVPSPNQGTIAVVSRT-DPDVTDIISKIDDPKTRMDTLLERRVMEMIGGGCFT 232 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGER-RGAPQDAEQMGISLAEELLNNGAREIL 303 P+G Y + + A V + +G + R ER DA++ G+ + E A +++ Sbjct: 233 PLGIYCKDR----LMIAEVLSLEGDRHFRLERLVSDIDDADRFGLEVRER-----AGDLI 283 Query: 304 AEVYNG 309 E Y Sbjct: 284 REAYER 289 >UniRef50_C3MZR8 Probable porphobilinogen deaminase n=11 Tax=Sulfolobus RepID=HEM3_SULIA Length = 293 Score = 293 bits (751), Expect = 5e-78, Method: Composition-based stats. Identities = 97/293 (33%), Positives = 147/293 (50%), Gaps = 9/293 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 +RIA R S L+ Q + +KL G+ E++ + T+ D+ PL+K+G KG+F K Sbjct: 2 KIRIAARGSKLSRIQVDMLGEKLKKI--GIEYEIIDIKTKADLFSTEPLSKLG-KGVFEK 58 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 E+ A+LE +ADIAVHSMKD+ E L + + ER+ P D ++ +LD L + Sbjct: 59 EVNEAVLEGKADIAVHSMKDILSEINPSLEIFAVLERDPPYDILIAEK--NLDKLDSNIT 116 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSS+RR+ L +P++ + +RGNV TR+ K + EY +ILA A LKRL + Sbjct: 117 IGTSSIRRKNFLKYIKPEINTKDIRGNVDTRIRKYLSKEYQGLILAEASLKRLNMTMNYH 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 + P QG + R D + +E+ +NH +T AERA+ + + GGC Sbjct: 177 RLNVYD-FTPEANQGIIVALGRKKDEKIKEIFKEINHKDTLDEALAERAVISLVGGGCHS 235 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 PIG + E + DG + I P D +G L L Sbjct: 236 PIGVLFKKEGKE--FYGIASYSDGKKKITVSIS-KPGDPYTIGSELGLLLKKE 285 >UniRef50_D2RNT2 Porphobilinogen deaminase n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RNT2_ACIFE Length = 288 Score = 292 bits (749), Expect = 8e-78, Method: Composition-based stats. Identities = 117/297 (39%), Positives = 163/297 (54%), Gaps = 14/297 (4%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L +ATR S LAL Q H V L + G+ E+ + T GD L K+GG+G+FV Sbjct: 2 KKLIVATRGSRLALAQTHIVCRLLEEA--GVETEIRTITTAGDRDRIHALVKIGGRGIFV 59 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 +E+E LL ADIAVHS KD+P + GL + + DPRDA V L+ AGS Sbjct: 60 REIERELLSGEADIAVHSAKDLPYQLASGLVIAGTPSQADPRDALVLLKERKLE---AGS 116 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +VGT S RR +++ P+L+ R +RGNV TRL KL+ GEYDAI+LA+AG++RL L+ Sbjct: 117 VVGTGSPRRIREISRVLPELVFRDIRGNVTTRLHKLERGEYDAIVLAMAGIQRLALDMEQ 176 Query: 184 RAA--LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 L E +PA QG +G+ECR D LL ++ ET R ER + T ++ Sbjct: 177 FQIRPLSTEQVIPAGCQGIIGVECRQKDRELVRLLQQISDPETWRRFQWERQLFTSMKVD 236 Query: 242 CQVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 C P+G + L G + L A+V DG + R G ++ + + SL EEL + Sbjct: 237 CSRPVGIHCRLLKSGRMELLAMV---DGKRARRL---GMEKEGKALCASLKEELYDR 287 >UniRef50_C0W553 Porphobilinogen deaminase n=2 Tax=Actinomycetales RepID=C0W553_9ACTO Length = 402 Score = 291 bits (747), Expect = 2e-77, Method: Composition-based stats. Identities = 129/387 (33%), Positives = 176/387 (45%), Gaps = 81/387 (20%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASH----PGLVVELVPMVTRGDVILDTPLAKVGGK 59 + +R+ TR S LAL Q+ V L + L VELVP+ TRGDV T L+++GG Sbjct: 2 STVRLGTRGSALALTQSGLVARMLEQAAALAGQELHVELVPVRTRGDVD-PTALSQLGGV 60 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD-SLDA 118 G+F L ALL D+AVHS KD+P GL + + REDPRD + L Sbjct: 61 GVFATALREALLAGECDLAVHSYKDLPTAAVPGLRIAAVPAREDPRDVLCTRAATLGLHD 120 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--------------DNGEY 164 LPAG+ VGT S RR QL +RPDL I +RGNV TRL+++ + Sbjct: 121 LPAGARVGTGSPRRSAQLLAQRPDLTIVPIRGNVPTRLARVVGSVVSADGPMGATAEPDL 180 Query: 165 DAIILAVAGLKRLGLESRIRAALP---------------------------PEISLPAVG 197 DA ILA++G++RLGLE L LPA Sbjct: 181 DAAILALSGMRRLGLEDYASQPLAARCGARSQVEVQGIPDGGSAAGSPATTEPWMLPAAA 240 Query: 198 QGAVGIECRLDDSRTREL------LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAE 251 QGA+ +E R D + EL LA ++ T AER++ L GC P+G+ A Sbjct: 241 QGALAVETR--DRVSCELPVLTVALALVDDPVTRACADAERSLMRCLAAGCAAPVGALAR 298 Query: 252 LID--------------------------GEIWLRALVGAPDGSQIIRGERRGAPQDAEQ 285 +D I L ALV + DG+Q+ R G ++AE Sbjct: 299 PLDVAGEPAAGRDLPTEPGTALEPGPDQAPAICLEALVASLDGTQLRRASATGTLEEAED 358 Query: 286 MGISLAEELLNNGAREILAEVYNGDAP 312 +G +AE LL +GA +I + +P Sbjct: 359 LGRCVAERLLADGAAQITDLQASKGSP 385 >UniRef50_Q4PFH9 Putative uncharacterized protein n=1 Tax=Ustilago maydis RepID=Q4PFH9_USTMA Length = 770 Score = 291 bits (745), Expect = 3e-77, Method: Composition-based stats. Identities = 115/296 (38%), Positives = 153/296 (51%), Gaps = 39/296 (13%) Query: 34 LVVELVPMVTRGDVILDTPLAKVGGKG--LFVKELEVALLENRADIAVHSMKDVPVEFPQ 91 + M T GD L +PL +GG+G ++ KELEVAL + D VH +KDVP PQ Sbjct: 249 HAFPITSMSTAGDQNLRSPLYVIGGEGKAIWTKELEVALEQGAVDAIVHCLKDVPTALPQ 308 Query: 92 GLGLVTICEREDPRDAFVSNNYDS---LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSL 148 GL L + EREDPRDA V LD LP GS++GTSS+RR QL R P L+ + Sbjct: 309 GLELAAVLEREDPRDALVVKAGLPYKVLDELPVGSVIGTSSVRRVAQLRRRYPHLVFSDV 368 Query: 149 RGNVGTRLSKLD--NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECR 206 RGN+ TRL+KLD NG Y A+ILA AGL RL + +RI A L + L +VGQG++ IE R Sbjct: 369 RGNINTRLAKLDAPNGPYTALILAAAGLVRLNMHARITAFLSSPVLLHSVGQGSLAIEVR 428 Query: 207 L----------DDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGE 256 D+R REL+ ++ R AER++ LEGGC +P+G D Sbjct: 429 TPPEGADPTTNRDARIRELIRSIGDWRATFRAEAERSLLKELEGGCSIPVGVETRFDD-- 486 Query: 257 IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYNGDAP 312 + G +A I+L ++ + G AE+ NG P Sbjct: 487 ----------------HDQVEGQRSEA----IALVDDFVTQGNAGAKAELPNGGMP 522 Score = 48.6 bits (115), Expect = 3e-04, Method: Composition-based stats. Identities = 28/89 (31%), Positives = 39/89 (43%), Gaps = 8/89 (8%) Query: 222 HETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR---G 278 T + AER ++T + S + L A+V + DGSQ R Sbjct: 573 PSTNAQTIAERIVSTSY----SIVDRSTPAPEGRTLHLDAIVVSLDGSQESRYSASKHCT 628 Query: 279 APQDAEQMGISLAEELL-NNGAREILAEV 306 +DA ++GI +A EL GAR IL EV Sbjct: 629 TVKDARELGIHVAHELAHKKGARAILEEV 657 >UniRef50_C8WDJ7 Porphobilinogen deaminase n=3 Tax=Zymomonas mobilis RepID=C8WDJ7_ZYMMN Length = 308 Score = 285 bits (730), Expect = 1e-75, Method: Composition-based stats. Identities = 116/292 (39%), Positives = 162/292 (55%), Gaps = 7/292 (2%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHP--GLVVELVPMVTRGDVILDTPLAKVGGK 59 + R+ +R SPLAL QA V L A+H V +VP+ T GD LA +GGK Sbjct: 1 MQLPFRLGSRGSPLALIQARSVASALCAAHSWSEDAVVIVPIRTSGDKNRHQALADIGGK 60 Query: 60 GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119 L+ KEL++AL + D AVHSMKDV P + + + RED D + SL+ L Sbjct: 61 ALWTKELDIALTTGQIDAAVHSMKDVETFRPSHISIAAMLPREDVHDRLIG--IPSLEVL 118 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179 P VGT+S RR Q+ RPD+ I+ LRGN+ TRL KL N ++DA +LA AGL RLG Sbjct: 119 PYSGCVGTASPRRAAQIRRIRPDIEIKLLRGNIDTRLEKLANKQFDATLLAAAGLIRLGR 178 Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 + +P + LPA GQGA+GIE DS E ++ ++H+ T L V +ER + RL Sbjct: 179 ND-VGYDVPLDQMLPAAGQGAIGIEALA-DSAAWEKVSIIDHYPTHLAVQSERQLLLRLN 236 Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGA-PQDAEQMGISL 290 C PI +AE+++ I LRA + +G ++ + P DA ++G L Sbjct: 237 ADCHSPIAVFAEILEKNIRLRACLYTENGKFSASIDKEISQPSDAFEVGSLL 288 >UniRef50_Q97B26 Probable porphobilinogen deaminase n=2 Tax=Thermoplasma RepID=HEM3_THEVO Length = 297 Score = 284 bits (728), Expect = 3e-75, Method: Composition-based stats. Identities = 86/267 (32%), Positives = 136/267 (50%), Gaps = 6/267 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 ++I TR S LA+ QA+ V L A G+ E+V + GD+ P+ +G G+FV+ Sbjct: 2 KIKIGTRPSNLAVAQANMVASSLEAI--GIDTEIVKHRSAGDIDTKNPIYSIGKTGVFVQ 59 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 +L +L D+AVHS KD+P E L + +R DA VS L +LP + Sbjct: 60 DLNNMILRGEIDVAVHSAKDIPSEIENRLTIAATLKRGSFNDALVSK--YDLRSLPISAK 117 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGTSS+RR QL R DL ++RGN+ TR++K+ DAI++A A ++RLGL Sbjct: 118 VGTSSIRRIFQLKYARQDLKFENIRGNIETRIAKMSELGLDAIVMAEAAIQRLGLNVEYS 177 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L +PA QG + + + + + R++L +N T + ER++ +L+ GC Sbjct: 178 K-LDENKFVPAPNQGIIAVVSKKEGT-VRKILEEINDENTFEEMQIERSVVQQLKLGCST 235 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQI 271 P+G + + A + G + Sbjct: 236 PVGILSRPSGKGHKIIAQFFSMQGDDV 262 >UniRef50_A2BFN7 Hydroxymethylbilane synthase (Fragment) n=6 Tax=Coelomata RepID=A2BFN7_DANRE Length = 247 Score = 283 bits (726), Expect = 4e-75, Method: Composition-based stats. Identities = 112/229 (48%), Positives = 144/229 (62%), Gaps = 4/229 (1%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 V+R+ TR+S LA Q V L +P + +E+V M T GD ILDT L+K+G K LF Sbjct: 19 SRVIRMGTRKSQLARIQTDSVAGTLKQLYPDVHLEIVAMSTIGDKILDTALSKIGEKSLF 78 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDAL 119 KELE AL N DI VHS+KD+P P G + I ERE+P DA V + +LD+L Sbjct: 79 TKELENALERNEVDIVVHSLKDLPTSLPPGFTIGAILERENPHDAVVLHPKNAGLTLDSL 138 Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLG 178 P S++GTSSLRR QL +R P L ++RGN+ TRL KLD +Y AIILA AGLKR+G Sbjct: 139 PEKSVIGTSSLRRAAQLKKRFPQLEFENIRGNLNTRLKKLDEKDDYAAIILAAAGLKRMG 198 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALR 227 ESRI L PE + AVGQGA+ +E R D E+++ L+H +T LR Sbjct: 199 WESRISQVLGPEDCMYAVGQGALAVEVRAQDKDILEMVSVLHHPDTVLR 247 >UniRef50_C1XV35 Porphobilinogen deaminase n=2 Tax=Meiothermus RepID=C1XV35_9DEIN Length = 304 Score = 283 bits (725), Expect = 5e-75, Method: Composition-based stats. Identities = 114/270 (42%), Positives = 159/270 (58%), Gaps = 11/270 (4%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + +RIATR S LA WQA +V +L G+ LV + T+GD +++ G+G Sbjct: 1 MSR-VRIATRGSRLARWQAEWVAAQLQDQ--GIASTLVIVETQGDRER-VAFSQMQGQGF 56 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP- 120 F K ++ A+ E RAD+AVHS+KD+P GL L I REDPR+A + P Sbjct: 57 FTKAVQDAVREGRADLAVHSLKDLPSAPTPGLVLAAIPIREDPREALLVLPSAWDAQAPA 116 Query: 121 ----AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKR 176 G+ VG+S++RRQ QLA+ RPDL + LRGNV TR+ KL +G Y+AI+LA AGLKR Sbjct: 117 LPLAPGARVGSSAVRRQAQLAQLRPDLKLLELRGNVPTRVEKLQSGGYEAILLAWAGLKR 176 Query: 177 LGLE--SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234 LGL+ L P +PA GQGA+ +ECR +D++ R +L L+ L V ER + Sbjct: 177 LGLDLGGLAVRLLEPREFVPAPGQGALALECREEDTQLRGVLQGLDDPTARLTVGIERGL 236 Query: 235 NTRLEGGCQVPIGSYAELIDGEIWLRALVG 264 RL+GGCQ+ +G+ A+ + G L A G Sbjct: 237 MARLQGGCQLALGASAQRVQGGWQLLAWYG 266 >UniRef50_C5C5B3 Porphobilinogen deaminase n=6 Tax=Actinomycetales RepID=C5C5B3_BEUC1 Length = 334 Score = 282 bits (722), Expect = 1e-74, Method: Composition-based stats. Identities = 120/294 (40%), Positives = 155/294 (52%), Gaps = 25/294 (8%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASH-----PGLVVELVPMVTRGDVILDTPLAKV 56 LR+ TR S LA Q+ + + + A + VELV + T GD +L LA + Sbjct: 18 STRTLRVGTRASALATTQSEWAGEAIAARVAAATGSDVEVELVRVTTTGD-VLTGSLASM 76 Query: 57 GGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSL 116 GG G+FV L ALL+ R D+AVHS+KD+P GL L + +REDPRD + L Sbjct: 77 GGTGVFVTALREALLDGRCDVAVHSLKDLPTAAAPGLVLGAVPQREDPRDVLCARAGAGL 136 Query: 117 DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGL 174 LPAG VGT S RR QL RPDL I +RGNV TRLS++ G+ DA++LA AGL Sbjct: 137 ADLPAGGRVGTGSPRRAAQLRRARPDLEIVDIRGNVDTRLSRISPGKGDLDAVVLARAGL 196 Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECR-LDDSRTRELLAALNHHETALRVTAERA 233 RLG + AL + +PA GQGA+ +E L A + T L VTAERA Sbjct: 197 ARLGRLDAVTEALDAGVMVPAPGQGALAVEAVDAAPDWLLAGLRAFDDAPTRLAVTAERA 256 Query: 234 MNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMG 287 M RLE GC P+G+ A L ++ LR VG +DAE +G Sbjct: 257 MLARLEVGCSAPVGALATLAGSQLLLRTSVG----------------EDAEDLG 294 >UniRef50_Q8I5V3 Porphobilinogen deaminase n=6 Tax=Plasmodium RepID=Q8I5V3_PLAF7 Length = 435 Score = 281 bits (721), Expect = 2e-74, Method: Composition-based stats. Identities = 95/367 (25%), Positives = 164/367 (44%), Gaps = 61/367 (16%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHP----GLVVELVPMVTRGDVILD-TPLAKVG 57 + + I TR SPLAL Q+ V+ K+M+ + V + T GD ILD + G Sbjct: 59 KDEIIIGTRDSPLALKQSEKVRKKIMSYFKKMNKNINVTFKYIKTTGDNILDSKSVGLYG 118 Query: 58 GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD 117 GKG+F KEL+ L+ D+ VHS+KDVP+ P + L +R+ DAF+S Y S++ Sbjct: 119 GKGIFTKELDEQLINGNVDLCVHSLKDVPILLPNNIELSCFLKRDTINDAFLSIKYKSIN 178 Query: 118 ALPAGS------------------------IVGTSSLRRQCQLAERRPDLIIRSLRGNVG 153 + +GTSSLRR+ Q+ R ++ + ++RGN+ Sbjct: 179 DMNTVKSVSKTEDIHHINKKDSDHNNDTLCTIGTSSLRRRSQIKNRYKNIYVNNIRGNIN 238 Query: 154 TRLSKLDNGEYDAIILAVAGLKRL--------------------------------GLES 181 TR+ KL NGE DA+I+A+ G++RL L Sbjct: 239 TRIEKLYNGEVDALIIAMCGIERLIKKANLKHLLKNKEQKNICQPFLLKCNNKKCIDLCH 298 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 L + PA+GQG + + + LL +N+ ++ + ER+ ++G Sbjct: 299 VNIQKLNKNLIYPALGQGIIAVTSHKKNYFISSLLKNINNKKSEMMAQIERSFLYHIDGN 358 Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301 C +PIG Y + + +I+L ++ G + ++ + +++G + A ++ E Sbjct: 359 CMMPIGGYTNMRNEDIYLHVIINDIHGYNKYQVTQKDTLYNYKEIGPNAAIKMKEIIGTE 418 Query: 302 ILAEVYN 308 ++ Sbjct: 419 QFNKIKA 425 >UniRef50_B4D5X7 Porphobilinogen deaminase n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4D5X7_9BACT Length = 307 Score = 281 bits (720), Expect = 2e-74, Method: Composition-based stats. Identities = 109/277 (39%), Positives = 149/277 (53%), Gaps = 14/277 (5%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPL---AKVGGKG 60 + + TR S LA+ Q L A+ P + +E VTRGD LD L + GGKG Sbjct: 2 KSIILGTRASALAVAQVELTTKALAAAFPAMQIERREFVTRGDKKLDLSLLRANEAGGKG 61 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 LF KELE ALL D+AVHS+KD+P P GL + + ER D ++ +L LP Sbjct: 62 LFTKELEDALLNGSIDVAVHSLKDLPGHNPPGLDITAVLERAPTADVLITKQPQTLLDLP 121 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGL 179 G ++GTSS+RR QL RRPD+ + RGNV TRL KL + IILA AGL+RLG Sbjct: 122 QGVLLGTSSVRRARQLQWRRPDVRVEEWRGNVQTRLRKLAERDDVTGIILAQAGLERLGH 181 Query: 180 ESRIRAALPP----------EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVT 229 + E LPA+GQGA+ ++ R D + +L ++H ET L + Sbjct: 182 DLSAGRLETEHGKFYVTSLAEDLLPAIGQGAIALQSRADRAEVAAVLQKIDHRETHLAIR 241 Query: 230 AERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAP 266 AER + L G C +P+G +L+ G I +RA++ P Sbjct: 242 AERELQRLLAGDCALPVGVRTKLLPGGIAMRAILFGP 278 >UniRef50_B0WMK9 Porphobilinogen deaminase n=1 Tax=Culex quinquefasciatus RepID=B0WMK9_CULQU Length = 474 Score = 281 bits (719), Expect = 3e-74, Method: Composition-based stats. Identities = 96/243 (39%), Positives = 133/243 (54%), Gaps = 29/243 (11%) Query: 13 SPLALWQAHYVKDKLMASHPGLVVELV------------------------PMVTRGDVI 48 S LAL Q YV L +P +V E+ M T GD + Sbjct: 167 SKLALIQTKYVISCLQKLNPDVVYEIRKYFQHVHLCWHVPSYLLAFFLSPDTMTTVGDRV 226 Query: 49 LDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAF 108 L+ L K+G K LF K+LE AL D VHS+KD+P P G+ + + ER+DPRDA Sbjct: 227 LNKSLPKIGEKSLFTKDLEDALRTGGVDFVVHSLKDLPTALPLGMAIGAVLERDDPRDAL 286 Query: 109 V---SNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG--E 163 V ++ +L LP GS+VGTSSLRR QLA + ++++ +RGN+ TRL+KLD + Sbjct: 287 VLNEAHRGRTLSTLPKGSVVGTSSLRRSAQLARKYENVVVCDIRGNLNTRLAKLDADGSK 346 Query: 164 YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHE 223 + IILA AGL R+G +R+ + P L AVGQGA+ +ECR +D ++L+ L H E Sbjct: 347 FAGIILAQAGLVRMGWNARVSQVIEPGEILYAVGQGALAVECRSNDEYILDMLSKLCHLE 406 Query: 224 TAL 226 T Sbjct: 407 TQC 409 >UniRef50_Q93A65 Porphobilinogen deaminase n=1 Tax=uncultured bacterium RepID=Q93A65_9BACT Length = 299 Score = 280 bits (717), Expect = 4e-74, Method: Composition-based stats. Identities = 120/296 (40%), Positives = 168/296 (56%), Gaps = 19/296 (6%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +R+ATR S LALWQA +V +L+ G VELV + T+GD P A++ G+G F K Sbjct: 4 VRLATRGSRLALWQAEWVAKQLVQQ--GAEVELVVVETQGDR-EKRPFAQMQGQGFFTKA 60 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN-----NYDSLDALP 120 ++ A+LE RAD AVHS KD+P P GL + + REDPR+ + L Sbjct: 61 VQEAVLEGRADFAVHSYKDLPSARPAGLEIAAVPPREDPRELLLVRLQAVDQVAPGLPLR 120 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180 AG+ VG+S+ RRQ QLA RPDL + LRGNV TR+ KL GEYDA++LA AG++RLGL+ Sbjct: 121 AGARVGSSAARRQAQLAHLRPDLSLLELRGNVLTRVEKLRQGEYDAVLLAYAGVRRLGLD 180 Query: 181 --SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238 LPP + +PA QGA+ +ECR DD R R LL L+ +R + RL Sbjct: 181 LSPFHWQVLPPTLLVPAPAQGALALECRQDDKRLRPLLEPLDDPSAGVRCGGA-GLMARL 239 Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 GGCQ+ +G+ A+ + L A + + RG+ D E + ++ +E+ Sbjct: 240 AGGCQLALGALAQETPEGLQLLAWY------RGRSYQARGS--DPEAVAEAVFKEI 287 >UniRef50_Q9Y9J0 Probable porphobilinogen deaminase n=1 Tax=Aeropyrum pernix RepID=HEM3_AERPE Length = 307 Score = 280 bits (717), Expect = 4e-74, Method: Composition-based stats. Identities = 106/294 (36%), Positives = 158/294 (53%), Gaps = 8/294 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVV--ELVPMVTRGDVILDTPLAKVGGKGLFV 63 +R+A R S L+L Q ++L + + G+ + E+V + + GDV D PL +G G+F Sbjct: 3 VRVAARGSRLSLLQVEQALEEL-SRYAGVSMHWEVVRVKSAGDVWSDRPLESIGVVGVFT 61 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQG-LGLVTICEREDPRDAFVSNNYD-SLDALPA 121 +E++ A+ ADIAVHS+KD+P G L +V I R RDA +S ++ L Sbjct: 62 REVDRAVASGAADIAVHSLKDMPTSGYGGPLKIVYIASRPSARDALISRQGPGRVEDLEP 121 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181 GS +GTSS RR+ P + + +LRGN+ TRL KL G YDAII + AGL RLG++ Sbjct: 122 GSTLGTSSARRRALSLHYNPRIRVENLRGNLDTRLRKLREGLYDAIIASEAGLIRLGVDV 181 Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241 L P PA GQG V + R+ S ++L L+ AER + G Sbjct: 182 EYT-PLDPSYFPPAPGQGFVAVVARVG-SNVEKMLRDLDKPPWWHVAWAERGVLEGARAG 239 Query: 242 CQVPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 C+ P+ +YAE + + + A +PDGS+ G ++A ++G+SL EEL Sbjct: 240 CRTPVAAYAEPLGRSMVRVTAAALSPDGSRAYWARAEGRIEEARRIGVSLGEEL 293 >UniRef50_Q0RS16 Porphobilinogen deaminase 1 (PBG 1) (Hydroxymethylbilane synthase 1) (HMBS 1) (Pre-uroporphyrinogen synthase 1) n=2 Tax=Frankia RepID=Q0RS16_FRAAA Length = 402 Score = 278 bits (713), Expect = 1e-73, Method: Composition-based stats. Identities = 121/366 (33%), Positives = 168/366 (45%), Gaps = 77/366 (21%) Query: 13 SPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLE 72 S LAL Q+ + +L G V+LVP+VT GD ++++GG G+FV L ALL Sbjct: 36 SALALTQSGMIAAQLRERV-GCAVDLVPIVTAGDR-SPAEISQIGGTGVFVSALRDALLA 93 Query: 73 NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRR 132 D+AVHS+KD+P P GL L + RED RD VS + L AL G+ V T + RR Sbjct: 94 GEIDLAVHSLKDLPTATPPGLVLAAVPTREDTRDVLVSPSGRGLAALGPGARVATGAPRR 153 Query: 133 QCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEIS 192 QL + ++RGNV TRL K +GE DA++LA AGL RL + L PE+ Sbjct: 154 AAQLRALGLGFDVVAIRGNVDTRLKKAIDGEVDAVVLAYAGLARLDRLDAVTEILDPEVM 213 Query: 193 LPAVGQGAVGIE------------------------------------------------ 204 LPA GQGA+ +E Sbjct: 214 LPAPGQGALAVECAAEAGLRLAGPARALVAAGAGDHADGDRPGAEAGRDGRGRGPDVGRN 273 Query: 205 ---CRLD-----DSRTRELLAA-LNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID- 254 R D D ELL L+ +++ + AERA +E GC P+G+ A Sbjct: 274 SGQTRSDHGQPLDGGLAELLRFVLDDASSSVAIRAERAFLAGIEAGCTAPVGALAVAEPA 333 Query: 255 -----------------GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 G + LRA+V APDGS ++R + G+ D E +G LA++LL+ Sbjct: 334 PAAAVGTVAPAGDASPAGRLRLRAVVAAPDGSTVLRRDVTGSAVDPEALGQRLADDLLSA 393 Query: 298 GAREIL 303 GA ++ Sbjct: 394 GAHSLM 399 >UniRef50_Q1GP41 Porphobilinogen deaminase n=7 Tax=Sphingomonadales RepID=HEM3_SPHAL Length = 315 Score = 274 bits (702), Expect = 2e-72, Method: Composition-based stats. Identities = 134/306 (43%), Positives = 169/306 (55%), Gaps = 10/306 (3%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGL--VVELVPMVTRGDVILDTPLAKVGGKG 60 DN LRI TR SPLA+ QAH L+A+H +E+VPM GD I D LA+VGGK Sbjct: 8 DNPLRIGTRASPLAMAQAHMAAAALIAAHGLAMAALEIVPMTATGDRIQDRALAEVGGKA 67 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLD 117 L+ +EL+ AL D+AVHS+KDV L + ER DPRD V + Sbjct: 68 LWTRELDAALDAGTIDVAVHSLKDVETLRDARFFLGAMLERADPRDRLVVREGIAAQKIS 127 Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177 LP G+ +GTSS RR Q+ RPDL LRGNV TRL+KL GE DA +LA AGL+RL Sbjct: 128 ELPHGARLGTSSPRRAAQVRRLRPDLDTVLLRGNVATRLAKLAAGEADATLLAAAGLERL 187 Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237 G+ I A E+ LPA QGA+GIECR DD+ T LLAA++H T V AERA+ Sbjct: 188 GM-HDIGAVQGTELLLPAASQGAIGIECRADDAATIALLAAIDHAPTHRAVAAERALLAV 246 Query: 238 LEGGCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296 L G C+ P+ +YAE DG + L A + + DG+ + G +L LL Sbjct: 247 LGGDCRSPVAAYAEWQADGVLRLDAEIFSEDGADHVAGHVIVTDAGVVA---ALGHRLLA 303 Query: 297 NGAREI 302 I Sbjct: 304 EAPPSI 309 >UniRef50_Q83H95 Porphobilinogen deaminase n=2 Tax=Tropheryma whipplei RepID=Q83H95_TROW8 Length = 321 Score = 271 bits (693), Expect = 3e-71, Method: Composition-based stats. Identities = 109/331 (32%), Positives = 154/331 (46%), Gaps = 42/331 (12%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR S LA Q V+ + L + V + T D G FV Sbjct: 3 PLRIGTRSSLLATAQTAQVQKTMRDVFL-LDTQQVLIQTGSVRRRD---------GSFVA 52 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 L ALLE D+AVHS+KD+P+ +G + + REDP D + +L LP+G+ Sbjct: 53 ALRTALLEGECDLAVHSLKDIPIAPHEGTLITAVLPREDPCDVLCARKDLTLTTLPSGAK 112 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 VGT+S RR+ Q+ RPDL + SLRGN+ RL LD DAI+L+ AGLKR+ E I Sbjct: 113 VGTASARRRAQILNFRPDLDVVSLRGNIDKRLIHLDT--LDAIVLSAAGLKRIDREDAIT 170 Query: 185 AALPPEISLPAVGQGAVGIE-CRL--DDSRTRELLA-ALNHHETALRVTAERAMNTRLEG 240 + A GQG++ IE CR DD + R + L++ + TAER + + L+ Sbjct: 171 ESFDIHDWPTAAGQGSLAIEVCRAQLDDPQNRVAVTYRLDNPMARVTTTAERGVLSLLQA 230 Query: 241 GCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRG--------------------ERRG 278 C PI +A D + L A V + DG Sbjct: 231 DCFSPIAVHAVYTANDKSLRLHAKVFSRDGKIFCESIRFARLVKQLTDTNQNHTKNSGSD 290 Query: 279 APQDAEQMGISLAE----ELLNNGAREILAE 305 +A ++ ++LA+ ELL+ AREIL + Sbjct: 291 DIGNALEVAMTLAKTVVDELLSKNAREILKQ 321 >UniRef50_UPI000038E213 porphobilinogen deaminase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E213 Length = 285 Score = 270 bits (690), Expect = 7e-71, Method: Composition-based stats. Identities = 91/266 (34%), Positives = 139/266 (52%), Gaps = 8/266 (3%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 + I TR S LAL QA+ VKD L + G V + + GD + PL ++ G+FV Sbjct: 2 PVTIGTRNSKLALIQANSVKDALESR--GYEVNIKSYTSAGDSNKNIPLYRMSSTGVFVD 59 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 EL +L+ D+AVHS KD+P +GL + + R+D RD +S L+ + AGS+ Sbjct: 60 ELNERVLKGEIDLAVHSAKDIPSNIQKGLEITAVTGRDDFRDVLISR--TPLEEMTAGSV 117 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +GTSS+RR Q P++ + +RGN+ TR+SK +Y II+A+A KR+ L+ Sbjct: 118 IGTSSMRRIRQAMTVNPEITVSDIRGNIDTRISKYTEKKYTGIIIAMAAYKRMKLDIE-H 176 Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 L E LPA QG + I + + + + +N ET + ER + T L GC + Sbjct: 177 FILSEEQFLPAPNQGIIAIVGKSNSPASI-ISGEINDRETYRDMKNERFIATSLNLGCSM 235 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQ 270 P+G ++ DG+I R D + Sbjct: 236 PVGILSK--DGKIKTRFYSLDSDEHR 259 >UniRef50_A9V9E0 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V9E0_MONBE Length = 643 Score = 268 bits (685), Expect = 2e-70, Method: Composition-based stats. Identities = 99/206 (48%), Positives = 124/206 (60%), Gaps = 6/206 (2%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 +RI TR S LA+WQ +V ++L +HPG+ +VP+ T GD L L K G+F Sbjct: 417 IRIGTRSSVLAMWQTRWVVERLTRAHPGVRFSVVPLSTVGDANLTLDLNKFSTTGIFTDA 476 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS----LDALPA 121 L ALL DI VHS+KD+P G L I REDPRD V ++ S L LPA Sbjct: 477 LVRALLAQEVDILVHSLKDLPSTISPGTQLAAIGPREDPRDVVVFHHRHSEIKDLAQLPA 536 Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN--GEYDAIILAVAGLKRLGL 179 G++VGTSS RR+ QLA P L +RGNV TRL KLD+ YDA+ LA AGL RLGL Sbjct: 537 GAVVGTSSTRRRAQLAAAYPQLRFAPVRGNVMTRLRKLDDPANGYDALCLAAAGLIRLGL 596 Query: 180 ESRIRAALPPEISLPAVGQGAVGIEC 205 E+RI LP +S A+GQGA+GI+ Sbjct: 597 EARIGQFLPLTVSRHAIGQGALGIQV 622 >UniRef50_UPI0001C31A39 porphobilinogen deaminase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31A39 Length = 314 Score = 262 bits (671), Expect = 1e-68, Method: Composition-based stats. Identities = 132/292 (45%), Positives = 169/292 (57%), Gaps = 13/292 (4%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 +VLRI TR S LAL QA +V L G VE++P+ T GD +G K +V Sbjct: 2 SVLRIGTRASALALVQAEHVASLLRDG--GAQVEVIPITTSGDRGR-----LLGDKSRWV 54 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 KELE ALL + D+AVHS KDVP E P G L + R D RDA SL+ LP G+ Sbjct: 55 KELEAALLADEVDVAVHSAKDVPAELPDGFVLAGVPARADARDALCG--AASLEQLPDGA 112 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +VGTSSLRR +L RPDL + +LRGNV TRL KL +G+ AI+LAVAGL+RL + I Sbjct: 113 VVGTSSLRRAAELRALRPDLGVVALRGNVDTRLRKLADGQAAAIVLAVAGLERLDRGAAI 172 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 A L + +PA GQGA+ +E R DD R R AA+ + A + AERA+ RL C Sbjct: 173 GAVL--DQLVPAPGQGALALETRADDDRARAAAAAITDADAAACLAAERALVRRLGATCH 230 Query: 244 VPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAPQ-DAEQMGISLAEE 293 P+G++A DG + LR+ VG PDGS +R E A D E G++ Sbjct: 231 TPLGAHAVRTADGGLRLRSFVGLPDGSAWLRDELSAAAGIDPETFGVAAGTR 282 >UniRef50_Q04X38 Bifunctional porphobilinogen deaminase/uroporphyrinogen synthase n=4 Tax=Leptospira RepID=Q04X38_LEPBL Length = 542 Score = 262 bits (670), Expect = 1e-68, Method: Composition-based stats. Identities = 89/279 (31%), Positives = 127/279 (45%), Gaps = 32/279 (11%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + VL+IA+R+S LA Q + V D L P + +EL GD+ L TPL K+G +G+ Sbjct: 1 MSRVLKIASRKSALAKLQTYLVLDALKKKFPNIQIELHFREASGDLDLQTPLWKMGTRGV 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F ++L L+E + D+ +HS KD+ +E G +V + +R D RD + P+ Sbjct: 61 FTQDLTKDLVEKKVDLVIHSWKDLDLEGHSGTTIVGVLDRADQRDVLLWKKSSLSKNFPS 120 Query: 122 GSIVGTSSLRRQCQLAERRPD----------LIIRSLRGNVGTRLSKLDNGEYDAIILAV 171 + TSS RR+ L + + LI +RGN+ TR+ K N + D ++LA Sbjct: 121 ELKIQTSSPRREYNLKKFLNNSLPSRYKNSSLIFLPVRGNIQTRIRKWRNSDSDGLVLAK 180 Query: 172 AGLKRL----------------------GLESRIRAALPPEISLPAVGQGAVGIECRLDD 209 A L RL LE I LP +S A QGA+ E R DD Sbjct: 181 AALDRLLSEDFLNSNELEYQEIRKFLKEILEESIFQVLPLSLSPSAPAQGAIAAEVRTDD 240 Query: 210 SRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGS 248 + AL+ E V ER R GGC IG Sbjct: 241 EWALGFVRALSKPEVVSAVEEERNTLKRFGGGCHQKIGV 279 >UniRef50_B0SF66 Bifunctional porphobilinogen deaminase/uroporphyrinogen synthase n=2 Tax=Leptospira biflexa serovar Patoc RepID=B0SF66_LEPBA Length = 511 Score = 261 bits (668), Expect = 2e-68, Method: Composition-based stats. Identities = 88/314 (28%), Positives = 136/314 (43%), Gaps = 37/314 (11%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + ++I R S L+ Q H V + L + L E + + GD L TPL + GG+G+ Sbjct: 1 MSETIKIGGRSSLLSRIQIHTVTNALKEKNKDLNFETIFRESSGDKDLTTPLWQFGGQGI 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F K+L+ LL ++ DI +HS KD+ ++ + L+ + RED RD + ++ LP Sbjct: 61 FTKDLQEDLLNHKVDIVIHSYKDMDLKERKETTLIPVLPREDVRDVLLFKKNKWIN-LPN 119 Query: 122 GSIVGTSSLRRQC----QLAERRPD------LIIRSLRGNVGTRLSKLDNGEYDAIILAV 171 + TSS RR+ L P + I S+RGN+ TRL K + E I++A Sbjct: 120 EITILTSSPRREYHIKEFLRNYFPTPINNFEIKIESVRGNIQTRLRKYLDHESGGILVAK 179 Query: 172 AGLKRL----------------------GLESRIRAALPPEISLPAVGQGAVGIECRLDD 209 A L R+ + + LP I A QGA+ E R +D Sbjct: 180 AALDRILNFQDPDQLLPELKEIQQLIKDTMNVSLFMVLPSSIFPSAPAQGALCAEIRKED 239 Query: 210 SRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYA--ELIDGEIWLRALVGAPD 267 LL+ ++ ET L ER + +R GGC IG ++R + D Sbjct: 240 KHLETLLSKISDSETNLTTNEEREILSRYGGGCHQKIGVTVLHREYGKVCFIRGI--TED 297 Query: 268 GSQIIRGERRGAPQ 281 G + E +P Sbjct: 298 GQILQTKELSESPN 311 >UniRef50_A7BMK1 Porphobilinogen deaminase n=1 Tax=Beggiatoa sp. SS RepID=A7BMK1_9GAMM Length = 211 Score = 261 bits (668), Expect = 2e-68, Method: Composition-based stats. Identities = 123/209 (58%), Positives = 148/209 (70%), Gaps = 1/209 (0%) Query: 101 REDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD 160 RE+P DAFVSN Y +L ALP G+IVGTSSLRRQ QL RPDL IRSLRGNVGTRLSKLD Sbjct: 3 REEPFDAFVSNTYATLAALPEGAIVGTSSLRRQSQLLAHRPDLQIRSLRGNVGTRLSKLD 62 Query: 161 NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALN 220 NG+YDAI+LA GLKRLGL RIR + I LPA+GQGA+GIECR DD TR+ + LN Sbjct: 63 NGDYDAIVLAAVGLKRLGLVERIREIIDSTIMLPAIGQGAIGIECRQDDLETRQHIDNLN 122 Query: 221 HHETALRVTAERAMNTRLEGGCQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGA 279 +T V AERA+N LEGGCQVPI YAE+ + +R LVG +G I+R +GA Sbjct: 123 DPDTQDCVIAERALNESLEGGCQVPIAGYAEIQSSENLTMRGLVGDIEGQHILRHNLQGA 182 Query: 280 PQDAEQMGISLAEELLNNGAREILAEVYN 308 A ++G SLA+ LL GA +IL ++ + Sbjct: 183 RHLAAELGKSLAKVLLTQGAAQILEKLKD 211 >UniRef50_A5K0J5 Porphobilinogen deaminase, putative n=1 Tax=Plasmodium vivax RepID=A5K0J5_PLAVI Length = 341 Score = 258 bits (661), Expect = 1e-67, Method: Composition-based stats. Identities = 91/337 (27%), Positives = 147/337 (43%), Gaps = 69/337 (20%) Query: 45 GDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDP 104 GD ILD + GGKG+F KEL+ L++ I VHS+KDVP+E P+ + L +R+ Sbjct: 2 GDHILDKKVGLFGGKGIFTKELDEQLIKKNVHICVHSLKDVPMELPEHVQLSCFLKRDTI 61 Query: 105 RDAFVSNNYDSLDALPAGS---------------------------------------IV 125 DAF+S Y +L+ + + Sbjct: 62 NDAFLSVKYATLEDMNKRKMANKVEEESDQEKGTIQQMTNQGLKRDNCEGDKCTNFIPTI 121 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 GTSSLRR Q+ ++ ++++RGN+ TR++KL NG+YDAII+A GL+RL + +R Sbjct: 122 GTSSLRRSSQIKYTYKNVAVKNVRGNINTRIAKLCNGQYDAIIIAKCGLERLLTKKVVRN 181 Query: 186 AL------PPEISL------------------------PAVGQGAVGIECRLDDSRTREL 215 + PPE L PA+ QG + + +D T + Sbjct: 182 IIRGKGKVPPEKFLLNHNDMETNLRLLRIQQINRRTIYPALCQGIIAVTSHKNDVDTSNI 241 Query: 216 LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE 275 L +N + + ER+ ++EG C +PIG YA+++ GEI A++ G + Sbjct: 242 LKNINDEKAQIMANVERSFLYQIEGNCMMPIGGYAQIVGGEIVFNAVINDTHGREKYHVR 301 Query: 276 RRGAPQDAEQMGISLAEELLNNGAREILAEVYNGDAP 312 G Q+ + A ++ ++ A Sbjct: 302 EVGTVQNCNNIAAMAATKMKEKIGTHRFNKIKEEAAQ 338 >UniRef50_B1ZV87 Porphobilinogen deaminase n=2 Tax=Opitutaceae RepID=B1ZV87_OPITP Length = 284 Score = 254 bits (649), Expect = 4e-66, Method: Composition-based stats. Identities = 94/260 (36%), Positives = 126/260 (48%), Gaps = 15/260 (5%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 L +ATR+SPLAL Q V L A G+ EL+ +VT GD + L + GGKGLF Sbjct: 2 KKLILATRKSPLALRQTEMVAAHLEAR-LGVQTELLKLVTTGDRQTEWSLEQKGGKGLFT 60 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 ELE AL AD+AVHS KD+P + L + R D RD V + A Sbjct: 61 SELENALRRGEADLAVHSTKDLPGDMAAELAVAGYLPRADARDVLVLRAG-----VAAPK 115 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESR 182 + T S RR+ Q+A+ P + +RGNV TRL K+ G D +LA AGL RLG+ + Sbjct: 116 SLATGSPRRRLQIAKLYPGVTFTEIRGNVDTRLKKIGELGVADGTVLASAGLNRLGIGNW 175 Query: 183 IRAALP---PEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239 +PAVGQGA+ ++CR D+ A + T V ERA L Sbjct: 176 PGVEFHALGFNDMVPAVGQGAIAVQCRAADAA---RFAPVFDAATKRAVDVERAFQAALG 232 Query: 240 GGCQVPIGSYAELIDGEIWL 259 GCQ G++ + + Sbjct: 233 VGCQTAFGAH--VAGDTLHF 250 >UniRef50_Q86ET2 Clone ZZD1450 mRNA sequence n=3 Tax=Schistosoma japonicum RepID=Q86ET2_SCHJA Length = 277 Score = 243 bits (620), Expect = 7e-63, Method: Composition-based stats. Identities = 100/329 (30%), Positives = 137/329 (41%), Gaps = 75/329 (22%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + +R+ +R+S LAL Q L P ++ E+V + T GD ILD PL+K+G K L Sbjct: 6 SQHAVRVGSRRSNLALLQTEMAISLLKVQKPHIMFEVVEIATVGDEILDVPLSKIGDKSL 65 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS---NNYDSLDA 118 F KELE +LL D+ VHS+KDVP P GL L + R P D + N L Sbjct: 66 FTKELEKSLLVGEVDLVVHSLKDVPSVLPTGLVLGCVFGRSSPEDVVLMAPHNRGMKLSD 125 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG--------------EY 164 LP G+ VGTSS+RR L + P L S+RGN+ TRL+KLD Y Sbjct: 126 LPVGATVGTSSIRRVATLIRKYPHLKFISIRGNLNTRLAKLDTPSNLQKQCCTGNQSLSY 185 Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224 DA+ILA AG++R+G RI L DS L + Sbjct: 186 DALILAKAGVERMGWVDRIDQVLS--------------------DSFYANELKGALDASS 225 Query: 225 ALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAE 284 +G LR + A+ Sbjct: 226 VF-------------------MGVAVTPSSEVSRLRMAI-------------------AQ 247 Query: 285 QMGISLAEELLNNGAREILAEVYNGDAPA 313 +G +A+ LL +GA EIL E+ + + Sbjct: 248 SLGCIVAKYLLLSGAGEILHEIRSQSTES 276 >UniRef50_C0EAN0 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum DSM 5476 RepID=C0EAN0_9CLOT Length = 292 Score = 237 bits (605), Expect = 4e-61, Method: Composition-based stats. Identities = 87/293 (29%), Positives = 127/293 (43%), Gaps = 16/293 (5%) Query: 4 NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63 + I Q+ L+ A ++ L + HP L ELVP+ G T L Sbjct: 13 EKIHIGCAQNELSRNFADHLAQCLHSYHPELTAELVPIKNTGADEEPT---------LVA 63 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 + LE AL++ R D+AV+ D+P+E L +V I RED RDA V P S Sbjct: 64 RRLEQALIDCRVDLAVYHALDLPLELHPELPIVAISSREDVRDALVFPQG---KQQPDFS 120 Query: 124 I-VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182 +G +S R+Q QL PD I + G V +L++LD GEY A++L A L GL+ R Sbjct: 121 KPIGCTSRRQQVQLHRVFPDCITAPVGGTVAEQLARLDQGEYGALVLPAAQLGWFGLQQR 180 Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 + E +PA G A+ ++ R LL + ++ V ER LE Sbjct: 181 VGQLFCVEELVPAAGHAAIAVQARE--EFDAGLLECFHSWDSWDAVFCEREFARALEEE- 237 Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295 PI +AE+ + + G +DA ++G LA EL Sbjct: 238 PGPIAVHAEVKGETLSVVGFYADEAEGIYRMSSMSGDRKDAGRLGFELAAELK 290 >UniRef50_Q6MHU0 Hydroxymethylbilane synthase n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MHU0_BDEBA Length = 502 Score = 235 bits (601), Expect = 1e-60, Method: Composition-based stats. Identities = 82/290 (28%), Positives = 123/290 (42%), Gaps = 37/290 (12%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 LRI+ R+S LA QA+ V D L +P + ++ + GD L PL K+ KG+F ++ Sbjct: 3 LRISARKSDLARLQAYMVGDALKEKNPQIEIDYRFRESLGDKNLTDPLWKIPEKGVFTED 62 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-----DSLDALP 120 LL + D+ VHS KD+P E + R D RD + + L Sbjct: 63 FFGELLRDETDLVVHSWKDLPTEHKSETVIAATLPRADQRDLLLVKKSHFDKIKTSKTL- 121 Query: 121 AGSIVGTSSLRRQCQL----AERRP----DLIIRSLRGNVGTRLSKL-DNGEYDAIILAV 171 V +SS RR+ L E P D+ S+RGN+ TR+ KL ++ E D +I+A Sbjct: 122 ---KVFSSSPRREYNLTGFFKEHLPFGLQDVKFESVRGNMLTRVRKLIESPETDGLIVAK 178 Query: 172 AGLKRLG-----------------LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRE 214 A RL LP ++ A QGA+ +E ++ Sbjct: 179 AAFDRLFSATLPEFLEGQQQLRQYFNELNWVVLPLSVNPNAAAQGALAVEVLKSRQDLQD 238 Query: 215 LLAALNHHETALRVTAERAMNTRLEGGCQVPIG--SYAELIDGEIWLRAL 262 LL +++H +T ER + + GGC IG A L+ L Sbjct: 239 LLQSIHHADTFHCSQKERDVLSSFGGGCHQKIGVAVLARPYGQITLLKGL 288 >UniRef50_Q4E9D5 Porphobilinogen deaminase (Fragment) n=1 Tax=Wolbachia endosymbiont of Drosophila ananassae RepID=Q4E9D5_9RICK Length = 199 Score = 233 bits (594), Expect = 8e-60, Method: Composition-based stats. Identities = 81/202 (40%), Positives = 121/202 (59%), Gaps = 6/202 (2%) Query: 97 TICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRL 156 + ER P DAF+S+ ++SL++LP + + TS++RR+ QL RPDL I LRGNV TRL Sbjct: 1 CVLERLSPCDAFISHKHNSLESLPQQATIATSAIRRKVQLLNFRPDLNIVPLRGNVTTRL 60 Query: 157 SKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELL 216 N +D IILA AGL RL I LPP++ L AVGQGA+ I+CR +D + +LL Sbjct: 61 ---QNQSFDGIILAEAGLIRLEKHHLITEVLPPKVMLSAVGQGAICIQCRRNDVKIIDLL 117 Query: 217 AALNHHETALRVTAERAMNTRLEGGCQVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGE 275 +N++ + + V +ER+ + G C P+ + AE + + ++LR ++ DG I E Sbjct: 118 EKINNNMSFIGVKSERSFMKTVNGSCFTPLAALAEYVSENMLYLRCMLA--DGKNIYFTE 175 Query: 276 RRGAPQDAEQMGISLAEELLNN 297 R +DAE+MG+ EL + Sbjct: 176 RTSFIEDAEKMGMDAGLELKSK 197 >UniRef50_B6YQR9 Hydroxymethylbilane synthase/uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YQR9_AZOPC Length = 682 Score = 225 bits (574), Expect = 2e-57, Method: Composition-based stats. Identities = 80/226 (35%), Positives = 119/226 (52%), Gaps = 18/226 (7%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG- 60 LR+ +R SPL+L Q V + P + +L+ + + GD L + Sbjct: 7 SKGNLRVISRNSPLSLLQVKEV----FSFFPNIDYQLITIESFGDKNKHVALFDISNVSS 62 Query: 61 ----------LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS 110 F +EL+ AL+ N+ADIAVHS KD+P P L L + + D D+ +S Sbjct: 63 FFLEEESISDFFTRELDEALIYNKADIAVHSAKDLPYPLPYDLELFALFQAMDKSDSLIS 122 Query: 111 NNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILA 170 N +L+ LP + VGTSS +R+ +L + RPDL + S+RGN+ R++K+DNG DA+I+A Sbjct: 123 RNNLTLEQLPPRARVGTSSQKRKTELLKIRPDLEVVSIRGNIEERIAKMDNGFIDALIVA 182 Query: 171 VAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELL 216 L RLG+E+RI LP E QG + I R +D + L Sbjct: 183 TCALIRLGMEARIACILPFETH---SLQGNLAIVGRKNDKNVKNLF 225 >UniRef50_Q6MEK3 Putative Porphobilinogen deaminase n=2 Tax=Parachlamydiaceae RepID=Q6MEK3_PARUW Length = 233 Score = 224 bits (571), Expect = 3e-57, Method: Composition-based stats. Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 3/218 (1%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65 + + R SPL+ Q + L + +P + + T GD+ T L + F KE Sbjct: 18 ISVGARSSPLSRAQVQEILKALRSFYPSIEFTISYFDTIGDLDQKTSLRDLDKTNFFTKE 77 Query: 66 LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125 ++ A+L+ + I +HS KD+P P GL L+ + + D D V + ++L LP S + Sbjct: 78 IDEAILQKKCQIGIHSAKDLPDPIPDGLQLICLTKGVDCSDVLVLRDGETLQTLPPHSRI 137 Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185 TSS+RR+ + R D I LRG + RL+ L+ + D +++A A L RLGL R Sbjct: 138 ATSSIRRENIVKLLRNDFIFLDLRGTIHQRLALLEKKQADGVVVAEAALIRLGLTHLNRI 197 Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHE 223 LP GQG + I R DD++ + L A L+ + Sbjct: 198 RLPGTTV---EGQGQLAIIARKDDAKMQTLFACLDVRK 232 >UniRef50_B4UXX3 Porphobilinogen deaminase 2 (Fragment) n=1 Tax=Streptomyces sp. Mg1 RepID=B4UXX3_9ACTO Length = 231 Score = 223 bits (568), Expect = 8e-57, Method: Composition-based stats. Identities = 88/231 (38%), Positives = 120/231 (51%), Gaps = 13/231 (5%) Query: 1 MLDN-----VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAK 55 M+ + +R+ TR SP+AL Q D A +P +V+++V +V+ GD PL+ Sbjct: 1 MMTSSTDLTTVRLGTRPSPMALEQTGRFADVFRARYPQVVLDIVEIVSEGDRHRG-PLST 59 Query: 56 VGGKGLFVKELEVALLENRADIAVHSMKDVPVEFP--QGLGLVTICEREDPRDAFVSNNY 113 +GGKG F + + LL+ R + KDVP G+ + + RED RDA V Sbjct: 60 IGGKGAFTRNADRYLLDGRVQATIACAKDVPGPHDRSPGIVIAAVLPREDTRDALVLPTG 119 Query: 114 D---SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDA--II 168 +L LP G+ VGTS+ RR L P L+ +RGN +RL LD G A +I Sbjct: 120 HPVTTLAELPPGTRVGTSAPRRSALLKALHPTLVQVPIRGNADSRLRALDAGRLGADVMI 179 Query: 169 LAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAAL 219 A+AGL+RLG E R L P + LPA G G V +E R DD T LLA L Sbjct: 180 AALAGLRRLGHEDRASEILDPAVWLPAAGAGTVIVEHRSDDPATGWLLAPL 230 >UniRef50_A8I2X7 Porphobilinogen deaminase n=1 Tax=Chlamydomonas reinhardtii RepID=A8I2X7_CHLRE Length = 380 Score = 218 bits (557), Expect = 1e-55, Method: Composition-based stats. Identities = 102/319 (31%), Positives = 137/319 (42%), Gaps = 36/319 (11%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMA----SHPGLVVELVPMVTRGDVILDTPLAKVGG 58 L IATR S LA Q V+ L+A L + + + +RGD L +G Sbjct: 60 QRPLVIATRPSKLAKEQTRQVQQLLLAAAQLKDEQLQLSTLELASRGDTTQGVSLRSLG- 118 Query: 59 KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118 G F +EL+ A+L AD++VHS+KD P GL L R DPRD ++ SL Sbjct: 119 SGAFTEELDQAVLSGAADMSVHSLKDCPAALAPGLLLAACLPRADPRDVLIAPEATSLGE 178 Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178 L GS VGTSS RR Q+ P L + LRGNV +RL ++ + + A +LA AGLKRLG Sbjct: 179 LVPGSRVGTSSSRRAAQIKHSFPHLQVVQLRGNVDSRLGRIRSRDIGATVLAAAGLKRLG 238 Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR- 237 + + GAVG+ CR DD LL A++H TAL V AERA Sbjct: 239 VMNSDEGD--------TTATGAVGVVCRADDEWVVGLLDAISHRGTALEVAAERACLAAL 290 Query: 238 --------------LEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER----RGA 279 + C + + L LV +G ++ R Sbjct: 291 LGGGGACQRSAFPDIAWACHTRH----DPDSNTMDLDCLVADLEGKELFRYTEFYRPVID 346 Query: 280 PQDAEQMGISLAEELLNNG 298 DA +G L Sbjct: 347 EVDAVSLGSLYGSLLRMMA 365 >UniRef50_Q6Q923 Predicted porphobilinogen deaminase n=2 Tax=environmental samples RepID=Q6Q923_9GAMM Length = 291 Score = 210 bits (535), Expect = 5e-53, Method: Composition-based stats. Identities = 82/252 (32%), Positives = 115/252 (45%), Gaps = 17/252 (6%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGL-VVELVPMVTRGDVILDTPLAKVGGKGLFV 63 ++IA+R S LAL Q K G+ +++ + T GD I + K FV Sbjct: 2 TIKIASRSSKLALAQVEEFVKKF-----GISDYKIIKVKTEGD-IKSANGETLFDKAHFV 55 Query: 64 KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123 +++ LL ADIAVHS KD P GL L + +D + D ++ Sbjct: 56 SDVQKCLLNGEADIAVHSAKDTPAGETTGL-LRYFLPSQSNQDVLIFREEDKFNS---EM 111 Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183 +GTSSLRRQ Q + I +L GNV TRL KL GEYD IILA AGL RL L + + Sbjct: 112 KLGTSSLRRQLQAKHHLNAINIVNLSGNVDTRLEKLSQGEYDCIILAKAGLARLKLLNEL 171 Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSR--TRELLAALN--HHETALRVTAERAMNTRLE 239 + + A GQG + IE D S LL ++ ++ ER++ + Sbjct: 172 QYEVM--DWSTASGQGFLCIEVLNDPSADIYNFLLKSIREIDLNLGKNISTERSILEAIN 229 Query: 240 GGCQVPIGSYAE 251 GC I + Sbjct: 230 AGCNSAISIQTQ 241 >UniRef50_Q9PK95 Probable porphobilinogen deaminase n=13 Tax=Chlamydiaceae RepID=HEM3_CHLMU Length = 242 Score = 207 bits (528), Expect = 3e-52, Method: Composition-based stats. Identities = 69/197 (35%), Positives = 105/197 (53%), Gaps = 3/197 (1%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LR+A+R+SPLA+ QAH +L P L +++ T+GD+ TPL V G F Sbjct: 20 PLRLASRKSPLAVLQAHECLRRLQTFFPRLWGQVITETTQGDLDQHTPLHSVENTGFFTD 79 Query: 65 ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124 +++ + + D+A+HS KD+P E P+ + I DPRD V L P+ Sbjct: 80 DIDFLVQSGKCDLAIHSAKDLP-EKPKARVI-AITASIDPRDILVFQEKYLLQPFPSRLR 137 Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184 +G SS RR+ ++ P +I +RG + TRL+ LD ++DAI++A A + RLGL Sbjct: 138 IGCSSDRRRALISSLYPSAVITDIRGTIQTRLALLDQQKFDAIVMANAAVSRLGLRLPCT 197 Query: 185 AALPPEISLPAVGQGAV 201 LPP P G+ A+ Sbjct: 198 VVLPPPYH-PFQGRLAI 213 >UniRef50_D0RNS6 Putative porphobilinogen deaminase (Pbg)(Hydroxymethylbilane synthase) (Hmbs) (Pre-uroporphyrinogen synthase) n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RNS6_9RICK Length = 492 Score = 203 bits (517), Expect = 6e-51, Method: Composition-based stats. Identities = 79/281 (28%), Positives = 120/281 (42%), Gaps = 28/281 (9%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + L I +R S LA Q VK +L + + T+GD K G G+ Sbjct: 1 MSLSLIIGSRASFLAKIQTFIVKQELKKKIKNIKITTKYHSTKGDKNQGHMPWKNLGYGI 60 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121 F L L+ + VHS KD+PV + + R+DPRD + Sbjct: 61 FTTSLTNELINKNFNCVVHSYKDLPVL--KSKTDYYVITRDDPRDVLLVKKKCLNK---K 115 Query: 122 GSIVGTSSLRRQCQLAERRP-----DLIIRSLRGNVGTRLSK-LDNGEYDAIILAVAGLK 175 IVGTSS RR+ + + + D+ +++RGNV TRL K + +YDA+ +A A + Sbjct: 116 KFIVGTSSPRRKSSVKDLKDLTGIKDIKTKTIRGNVTTRLLKVISKNQYDAVFMAKAAID 175 Query: 176 R----------------LGLESRIR-AALPPEISLPAVGQGAVGIECRLDDSRTRELLAA 218 R L L + + LP I A QGA+ +E +D +T+ L Sbjct: 176 RIFKYGNKVDKVETKKFLNLFKKFKPFILPLSIFPTAASQGAIAVEYLKNDKKTKSTLNK 235 Query: 219 LNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWL 259 +N +T ER++ + GGC + IG E I +L Sbjct: 236 INCKKTLSICNQERSLLKKYGGGCGLDIGITIEEIKNNNFL 276 >UniRef50_C5LJF7 Porphobilinogen deaminase, putative n=5 Tax=Perkinsus marinus ATCC 50983 RepID=C5LJF7_9ALVE Length = 556 Score = 200 bits (510), Expect = 4e-50, Method: Composition-based stats. Identities = 79/298 (26%), Positives = 115/298 (38%), Gaps = 40/298 (13%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62 +VL I +R+S LA Q + D L G+ VE GD L PL K+ G+F Sbjct: 7 PSVLHIGSRRSDLARLQTLMIADLLQDEM-GVKVECHYREAPGDTNLKDPLWKMPETGVF 65 Query: 63 VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 L L+ D+ VHS KD+P+ G +V R DPRD + + G Sbjct: 66 TSFLRDGLMNGAFDLVVHSWKDLPLAEESGTTVVATLPRADPRDLLLIRRDAIEEMTSEG 125 Query: 123 SI--VGTSSLRRQCQLAERRP-------DLIIRSLRGNVGTRLSKLDNGEY--------- 164 V +SS RRQ L + R +RGN+ TR+ KL + Sbjct: 126 GKLIVLSSSPRRQFNLTPFLESVVPGVTSVQFRDVRGNIQTRMKKLMDPTIHDESLGCRP 185 Query: 165 DAIILAVAGLKRL----------------GLESRIRA-ALPPEISLPAVGQGAVGIECRL 207 +++A A + R G S R LP + A QGA+GIE Sbjct: 186 HGLVVAKAAVDRFIRSTREEFKESRQLVQGYISECRCMVLPLSANPTAAAQGALGIEVST 245 Query: 208 --DDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGS--YAELIDGEIWLRA 261 + R+++ +LN T + E+ + GGC IG ++L Sbjct: 246 APEKEHVRKIVRSLNDRSTFDAASKEKELLNSYGGGCHQKIGCTILPRQYGDVLFLCG 303 >UniRef50_Q9HMY5 Probable porphobilinogen deaminase n=2 Tax=Halobacterium salinarum RepID=HEM3_HALSA Length = 396 Score = 196 bits (499), Expect = 1e-48, Method: Composition-based stats. Identities = 72/165 (43%), Positives = 96/165 (58%), Gaps = 2/165 (1%) Query: 1 MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60 M +R+ATR S LAL QA V D L VELV + T GD + D ++ +G G Sbjct: 1 MSSQQIRLATRGSDLALRQAGEVVDTLEDRR--HDVELVEVETEGDRVTDALISDLGKTG 58 Query: 61 LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120 FV+ L+ ++E D AVHSMKDVP E P+ L + + RE+P D V+ + L+ LP Sbjct: 59 AFVRALDQEVMEGTVDAAVHSMKDVPTEVPEDLVVAAVPHRENPADVLVTPDGTDLEDLP 118 Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYD 165 AGS+VGT+SLRR Q+ RP L + +RGNVGTR+ KL Sbjct: 119 AGSVVGTASLRRGAQVQAHRPGLDVEPIRGNVGTRVEKLLAPALH 163 Score = 138 bits (348), Expect = 3e-31, Method: Composition-based stats. Identities = 48/146 (32%), Positives = 70/146 (47%), Gaps = 1/146 (0%) Query: 163 EYDAIILAVAGLKRLGLESRIR-AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNH 221 EYDA+++A GL+R GL + L +PA GQGA+ + R D L AL H Sbjct: 248 EYDALVMARVGLERTGLLHHVGIEELSTGTHVPATGQGALCVTARRDSDVVDTLRDALEH 307 Query: 222 HETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ 281 T + VTAER + L GGC PIG +A + I V + DGS+ + R + Sbjct: 308 VRTRVEVTAERVVLEELGGGCIAPIGVHALVQGDTIRTAVQVFSQDGSEQVGETRELDAE 367 Query: 282 DAEQMGISLAEELLNNGAREILAEVY 307 LA +L + GA +++ + Sbjct: 368 QYATDARELAADLRDRGAADLIEDAR 393 >UniRef50_Q18ES3 Hydroxymethylbilane synthase (Porphobilinogen deaminase) n=9 Tax=Halobacteriaceae RepID=Q18ES3_HALWD Length = 394 Score = 181 bits (461), Expect = 2e-44, Method: Composition-based stats. Identities = 66/157 (42%), Positives = 95/157 (60%), Gaps = 4/157 (2%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 L +ATR S LAL QA V++ L V+L+ + TRGD I D + ++G G FV+ Sbjct: 10 TLTLATRGSDLALKQATSVQEALTDER--YEVDLIEVETRGDQIQDELIHQLGKTGAFVR 67 Query: 65 ELEVALLE--NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122 L+ +L+ AD AVHSMKD+P + P L + I +R P D ++ + L LP+G Sbjct: 68 ALDKKVLDPTAEADAAVHSMKDMPTDSPDDLVVAGIPQRAPPGDLLITTDGQRLSDLPSG 127 Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL 159 + +GTSSLRRQ QL ++R D+ + LRGN+ TR+ KL Sbjct: 128 ATIGTSSLRRQAQLLDQRTDITVEPLRGNIDTRIEKL 164 Score = 137 bits (345), Expect = 6e-31, Method: Composition-based stats. Identities = 52/153 (33%), Positives = 76/153 (49%), Gaps = 1/153 (0%) Query: 156 LSKLDNGEYDAIILAVAGLKRLGLESRIRAA-LPPEISLPAVGQGAVGIECRLDDSRTRE 214 L + EYDAI+LA AGL+R GL I L +PA GQGA+ I + + + T + Sbjct: 228 LERSVETEYDAIVLAEAGLQRSGLIHHIEYVQLDTTTFVPAPGQGAIAITTQGEANATAQ 287 Query: 215 LLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRG 274 + A++H T + T ER + L GGC PIG +A L + + A V A DG++ + G Sbjct: 288 IREAIDHPRTRVETTVERTVLAELGGGCIAPIGVHATLQGEYVHVAAQVFASDGTETVDG 347 Query: 275 ERRGAPQDAEQMGISLAEELLNNGAREILAEVY 307 R A +L + GA E++A Sbjct: 348 SRNLPVDAHADAAAQFANKLADRGADELIAAAR 380 >UniRef50_UPI000155526F PREDICTED: similar to hydroxymethylbilane synthase n=1 Tax=Ornithorhynchus anatinus RepID=UPI000155526F Length = 218 Score = 166 bits (420), Expect = 1e-39, Method: Composition-based stats. Identities = 60/130 (46%), Positives = 78/130 (60%), Gaps = 9/130 (6%) Query: 75 ADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALPAGSIVGTSSLR 131 D+ VHS+KD+P P G + +C+RE P DA V + +L LP S+VGTSSLR Sbjct: 90 VDLVVHSLKDLPTVLPPGFTIGAVCKRESPYDAVVFHPKHVGKTLATLPEKSVVGTSSLR 149 Query: 132 RQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESRIRAALPPE 190 R QL + P L +S+RGN+ TRL KLD E+ AIILA AGL+RLG +SR+ Sbjct: 150 RAAQLQRKFPHLEFKSIRGNLNTRLRKLDELQEFSAIILAAAGLQRLGWQSRLGQV---- 205 Query: 191 ISLPAV-GQG 199 PA G+G Sbjct: 206 RVAPAPRGRG 215 >UniRef50_B0KCR7 Porphobilinogen deaminase n=3 Tax=Thermoanaerobacter RepID=B0KCR7_THEP3 Length = 168 Score = 161 bits (408), Expect = 3e-38, Method: Composition-based stats. Identities = 48/164 (29%), Positives = 82/164 (50%), Gaps = 7/164 (4%) Query: 136 LAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPA 195 + D+ I +RGNV TRL K++ D I+L+ AGL RLGLES I PP++ +PA Sbjct: 4 IQALMSDIQIVPIRGNVRTRLKKMEELNLDGIVLSAAGLHRLGLESIITEYFPPDVVVPA 63 Query: 196 VGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAEL-- 252 QG + +E D+ +E + + T + ER + C+ P G+YA+ Sbjct: 64 PCQGILAVEIAESFDNIFQEFYSYIVDRRTFFEASVERELLKAFGVNCRQPFGAYAQYRK 123 Query: 253 --IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294 + +I ++ + D ++++ E G ++ ++M L EE Sbjct: 124 EKDEEKINIKVVYQKED--KLLKSEVTGLIEETDKMIEKLIEEF 165 >UniRef50_C0DZX9 Putative uncharacterized protein n=1 Tax=Corynebacterium matruchotii ATCC 33806 RepID=C0DZX9_9CORY Length = 152 Score = 154 bits (391), Expect = 3e-36, Method: Composition-based stats. Identities = 54/150 (36%), Positives = 79/150 (52%), Gaps = 1/150 (0%) Query: 156 LSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTREL 215 ++K+ +GE DA++LA AGL R+ P LPA QGA+ +ECR DD+ T Sbjct: 1 MAKVHDGELDAVVLAYAGLSRVHRADEATEVFDPLEFLPAPAQGALAVECRADDADTIAA 60 Query: 216 LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEI-WLRALVGAPDGSQIIRG 274 + + + ER + RLE GC P+ +YA + I L A V A DGS +R Sbjct: 61 ITTIADSKAYACAHTERVVLARLEAGCTAPVAAYATVAADNIMTLHAAVIAMDGSATLRA 120 Query: 275 ERRGAPQDAEQMGISLAEELLNNGAREILA 304 G AE +G+++A LL++GA +LA Sbjct: 121 TAAGPIDTAENLGMTVARALLDDGASSLLA 150 >UniRef50_UPI0001B4213A porphobilinogen deaminase n=1 Tax=Listeria monocytogenes LO28 RepID=UPI0001B4213A Length = 128 Score = 144 bits (365), Expect = 3e-33, Method: Composition-based stats. Identities = 51/124 (41%), Positives = 78/124 (62%), Gaps = 2/124 (1%) Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244 +PPE+ LPAVGQGA+ IECR D + R++L +++H ET + V AER +L GGC++ Sbjct: 6 EDIPPEVCLPAVGQGALAIECRESDQQIRDMLTSIHHEETGICVEAERVFLKKLNGGCEI 65 Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304 PI +A + + + LVG DGS I+ E+ G + ++G +AE+LL+ GA I+ Sbjct: 66 PIAGFATRANEFVQFKGLVGNADGSIILESEQVG--ANPSEIGNKVAEDLLSEGADTIIK 123 Query: 305 EVYN 308 E+ N Sbjct: 124 ELRN 127 >UniRef50_A8CBG6 Porphobilinogen deaminase n=3 Tax=Toxoplasma gondii RepID=A8CBG6_TOXGO Length = 747 Score = 143 bits (361), Expect = 8e-33, Method: Composition-based stats. Identities = 56/163 (34%), Positives = 74/163 (45%), Gaps = 33/163 (20%) Query: 124 IVGTSSLRRQCQLAERRP--DLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL-- 179 +GT SLRRQ L P + LRGNV TR+S+++ G DA +LA AGLKRL L Sbjct: 444 RIGTCSLRRQALLYALLPPSSFQLMGLRGNVQTRMSRIEKGTLDATLLAAAGLKRLNLLS 503 Query: 180 ---------------------ESRIRAA--------LPPEISLPAVGQGAVGIECRLDDS 210 SR LP ++ +PAV QG +G++CR D+ Sbjct: 504 AMLAPSPSATPSPCPAPSPNETSRGTEPGGCVEAVLLPADVFVPAVCQGIIGVQCRSADT 563 Query: 211 RTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELI 253 LL LN + + ERA L+G C+ PI AE Sbjct: 564 GILSLLRELNSPSSRGQALCERAFLRALDGSCRTPIAGIAEWR 606 Score = 117 bits (295), Expect = 4e-25, Method: Composition-based stats. Identities = 44/96 (45%), Positives = 56/96 (58%), Gaps = 3/96 (3%) Query: 23 VKDKLMASHPGLVV---ELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAV 79 V L+ L +VPM T GD L PLA+VGGKGLF KEL++ALL + D+ V Sbjct: 253 VLASLLRVDSRLEYGELRIVPMQTTGDKELHLPLAQVGGKGLFTKELDLALLHGQVDVVV 312 Query: 80 HSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS 115 HS+KDVP E P+G + REDPRDA + + Sbjct: 313 HSLKDVPTELPEGTEIGAYLPREDPRDALIFSRKPR 348 Score = 52.4 bits (125), Expect = 2e-05, Method: Composition-based stats. Identities = 18/67 (26%), Positives = 32/67 (47%), Gaps = 5/67 (7%) Query: 247 GSYAELIDGEI-WLRALVGAPDGSQIIRGERRG----APQDAEQMGISLAEELLNNGARE 301 G A ++ ++ PDG Q+ R ER P++AE +G ++AEE+ + Sbjct: 669 GVLATPDGKQLLRFCGVLATPDGKQLFREERTVRGVRTPEEAEALGRAVAEEIKKAAGAD 728 Query: 302 ILAEVYN 308 LA++ Sbjct: 729 RLAQIKK 735 Score = 44.3 bits (104), Expect = 0.006, Method: Composition-based stats. Identities = 12/31 (38%), Positives = 15/31 (48%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPG 33 LR+ +R SPLAL QA +L P Sbjct: 160 KTPLRVGSRASPLALAQARQFVYRLALRFPD 190 >UniRef50_UPI0001742E92 Porphobilinogen deaminase n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI0001742E92 Length = 119 Score = 133 bits (335), Expect = 1e-29, Method: Composition-based stats. Identities = 32/115 (27%), Positives = 60/115 (52%), Gaps = 2/115 (1%) Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242 + + +PA GQG + I+CR +D++ R LL +N E + AER + +GGC Sbjct: 1 MSEYFDTDFFMPAPGQGILCIQCRENDNKIRHLLEIINDDEVTMMCEAEREFSKIFDGGC 60 Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297 PIG + + + L+ + +GS++++ E G ++ +++ LAEE+ Sbjct: 61 HTPIGCSSVIEGDTLKLKGM-FNDNGSRMLK-EVEGNKENPKEIAQKLAEEIKKE 113 >UniRef50_C4Z1K5 Putative uncharacterized protein n=1 Tax=Eubacterium eligens ATCC 27750 RepID=C4Z1K5_EUBE2 Length = 287 Score = 126 bits (317), Expect = 1e-27, Method: Composition-based stats. Identities = 48/242 (19%), Positives = 96/242 (39%), Gaps = 34/242 (14%) Query: 55 KVGGKGLFVKELEVALLENRADIAVHSMKDVPV---------EFPQGLGLVTICEREDPR 105 ++GG ++ LE AL+++ D+ + D+ + + G+ + + +R DPR Sbjct: 42 EIGGSDIY-PALE-ALIDDNIDMV---LVDMRMLVEMEKSGQQLDDGIVISGVIKRRDPR 96 Query: 106 DAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYD 165 + + ++V T S + E ++ + N+ +SKLD+ E D Sbjct: 97 YVMIRRRGT--KDVVENAVVVTDSDENAAVICEMYDNVECV-VENNIKDCMSKLDSEECD 153 Query: 166 AIILAV---AGLKRL--GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALN 220 A + A + RL GL+ + + +P GQG I S + + ++ Sbjct: 154 A-VFAFYDDIRIARLYNGLKYKYT-LMDFSDCVPPHGQGIYCILTNGKRSVIKHMFD-VS 210 Query: 221 HHETALRVTAERAMNTRLEG-----GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE 275 H TA+ E + RL C +Y ++ +I + A V G+ ++ + Sbjct: 211 HRTTAMSFDIEEDIIRRLLMNDYVKSCN----AYVKISGDKIEVYADVKGYRGNIKVQEK 266 Query: 276 RR 277 Sbjct: 267 DE 268 >UniRef50_Q401C3 Hydroxymethylbilane synthase (Fragment) n=7 Tax=Coelomata RepID=Q401C3_CAPHI Length = 109 Score = 124 bits (311), Expect = 6e-27, Method: Composition-based stats. Identities = 44/93 (47%), Positives = 59/93 (63%), Gaps = 4/93 (4%) Query: 104 PRDAFVSNN---YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD 160 P +A V + +L+ LP S+VGTSSLRR QL + P L R++RGN+ TRL KLD Sbjct: 17 PMNAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRNIRGNLNTRLRKLD 76 Query: 161 N-GEYDAIILAVAGLKRLGLESRIRAALPPEIS 192 E+ AIILA AGL+R+G ++R+ L PE Sbjct: 77 ELQEFSAIILAAAGLQRMGWQNRVGQILHPEEC 109 >UniRef50_UPI0001698669 porphobilinogen deaminase n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2' RepID=UPI0001698669 Length = 136 Score = 120 bits (302), Expect = 5e-26, Method: Composition-based stats. Identities = 64/133 (48%), Positives = 79/133 (59%), Gaps = 11/133 (8%) Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231 AGLKRLG E RI A + PE SLPA+GQGA+GIECR DD++ L+A L+H +TA V AE Sbjct: 8 AGLKRLGFEQRITAFIAPEQSLPAIGQGAIGIECRSDDAQVNALIAPLHHVDTAACVHAE 67 Query: 232 RAMNTRLEGG-----CQV-PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQ 285 RAMN RL GG C++ G A W R+ V + GE G P +AE Sbjct: 68 RAMNNRLMGGSPCADCRLRDAGVPATSGCVVWWARSTVA-----RSCVGEAEGTPDEAES 122 Query: 286 MGISLAEELLNNG 298 +G+ LAE LL G Sbjct: 123 LGVGLAERLLELG 135 >UniRef50_Q1HRH6 Hydroxymethylbilane synthase-like protein n=1 Tax=Aedes aegypti RepID=Q1HRH6_AEDAE Length = 349 Score = 118 bits (297), Expect = 2e-25, Method: Composition-based stats. Identities = 34/111 (30%), Positives = 52/111 (46%), Gaps = 6/111 (5%) Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236 +G E RI + P L AVGQGA+ +ECR +D +L+ L H ET ++ ER+ Sbjct: 1 MGWEKRIDQVIEPSEILYAVGQGALAVECRSNDEYILNMLSKLCHLETQCKILVERSFLK 60 Query: 237 RLEGGCQVPIGSYAEL------IDGEIWLRALVGAPDGSQIIRGERRGAPQ 281 L GGC P+ L + ++ V + DG IR + + + Sbjct: 61 TLGGGCSAPVAVCTSLKRKHDSKSNYLNIQGAVWSLDGKTEIRADDGCSVE 111 >UniRef50_C5G109 Porphobilinogen deaminase n=1 Tax=Microsporum canis CBS 113480 RepID=C5G109_NANOT Length = 282 Score = 112 bits (280), Expect = 2e-23, Method: Composition-based stats. Identities = 54/233 (23%), Positives = 81/233 (34%), Gaps = 48/233 (20%) Query: 84 DVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDL 143 DV + P I + Y SL LP G+I+ TS +R QL P L Sbjct: 93 DVSTKLPDSCDPAAIPVKA-------GLPYTSLQTLPEGAIIATSLVRPSAQLRRLFPTL 145 Query: 144 IIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGI 203 ++RGNV + + + A LG P QG Sbjct: 146 RFANVRGNVES------------LTIPQA----LGTVGSSTRGRPRARRR--RHQGY--- 184 Query: 204 ECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALV 263 + + + L AL + L L GC PIG E + +RA+V Sbjct: 185 ----SSAGSADRLLAL---PSVLMC--------ALRSGCNAPIGIETEWTATHLSIRAIV 229 Query: 264 GAPDGSQIIRGERRG---APQDAEQMGISLAEELLNNGAREILAEVYNGDAPA 313 + D SQ + +++ G +LA L G IL ++ N + P+ Sbjct: 230 VSLDISQSVEDAIDAMMHTKDESDAPGQALA-RLFGAGVAPILIDI-NRNQPS 280 >UniRef50_B8N6H4 Putative uncharacterized protein n=1 Tax=Aspergillus flavus NRRL3357 RepID=B8N6H4_ASPFN Length = 90 Score = 100 bits (250), Expect = 6e-20, Method: Composition-based stats. Identities = 30/79 (37%), Positives = 40/79 (50%) Query: 5 VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64 LRI TR+S LA+ QA +++ L PG E+ + T GD T L G K L+ Sbjct: 10 PLRIGTRRSNLAMVQAEGIRNCLQKIAPGRSFEIEALRTLGDRDQLTALYNFGAKSLWTT 69 Query: 65 ELEVALLENRADIAVHSMK 83 ELE L D+ VH +K Sbjct: 70 ELEEKLNAGELDVIVHCLK 88 >UniRef50_UPI0000D9FBB5 PREDICTED: similar to lethal (3) 02640 CG9165-PA n=1 Tax=Macaca mulatta RepID=UPI0000D9FBB5 Length = 105 Score = 99.8 bits (248), Expect = 1e-19, Method: Composition-based stats. Identities = 34/113 (30%), Positives = 45/113 (39%), Gaps = 17/113 (15%) Query: 2 LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61 + LRI +R+S LA Q V D+L G V LV M G+ Sbjct: 5 SNATLRIGSRRSDLARLQTLMVADRLEE--MGYKVVLVGM---------------PETGV 47 Query: 62 FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD 114 F L LL+ D+ VHS KD+P+ G + R DPRD + Sbjct: 48 FTTFLRQKLLDGSVDLVVHSWKDLPLAEEAGTTVAATLPRADPRDLIIIRKDA 100 >UniRef50_UPI0001C35DE1 porphobilinogen deaminase n=1 Tax=Clostridium hathewayi DSM 13479 RepID=UPI0001C35DE1 Length = 121 Score = 89.0 bits (220), Expect = 2e-16, Method: Composition-based stats. Identities = 25/112 (22%), Positives = 47/112 (41%), Gaps = 3/112 (2%) Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243 E +PA GQG + +E R++D R E+ + + + ER + L+ GC Sbjct: 13 FHYFACEAFIPAGGQGILAVEGRIED-RICEMAVRIQDEDAKTCLMLERKILKLLDAGCH 71 Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295 P+G Y+ + EI + + + + R G + + + A+ L Sbjct: 72 EPVGVYSRIRGEEIEVFGI--SRRDRETKRVYLTGGIGELDLLAERAAKGLR 121 >UniRef50_C5U771 Porphobilinogen deaminase n=1 Tax=Methanocaldococcus infernus ME RepID=C5U771_9EURY Length = 89 Score = 73.6 bits (180), Expect = 9e-12, Method: Composition-based stats. Identities = 24/83 (28%), Positives = 34/83 (40%), Gaps = 3/83 (3%) Query: 217 AALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER 276 +N +T L TAER L GC VP G++A+ + L+ V D Sbjct: 2 EKINDKKTFLETTAERKALNELGCGCHVPFGAFAKYEGKRLMLKVAVANKDRVIKKESSI 61 Query: 277 RGAPQD---AEQMGISLAEELLN 296 + AE++G SL EL Sbjct: 62 CCEVDEIEKAEKLGESLGRELRR 84 >UniRef50_Q4EB45 Porphobilinogen deaminase n=1 Tax=Wolbachia endosymbiont of Drosophila ananassae RepID=Q4EB45_9RICK Length = 62 Score = 62.8 bits (152), Expect = 1e-08, Method: Composition-based stats. Identities = 20/50 (40%), Positives = 30/50 (60%) Query: 6 LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAK 55 ++I TR S LA+ QA K KL+ S P L +E+V + + GD + LA+ Sbjct: 13 VKIGTRGSKLAVVQALEAKQKLLDSFPNLSIEIVKIKSSGDKYANANLAE 62 >UniRef50_B5XH53 Porphobilinogen deaminase n=1 Tax=Salmo salar RepID=B5XH53_SALSA Length = 55 Score = 59.7 bits (144), Expect = 1e-07, Method: Composition-based stats. Identities = 15/39 (38%), Positives = 22/39 (56%) Query: 3 DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPM 41 V+RI TR S LA Q V +KL +P + +E+V + Sbjct: 16 SRVIRIGTRNSQLARIQTDSVAEKLKGLYPDVHIEIVGI 54 >UniRef50_C2BR76 Putative uncharacterized protein (Fragment) n=1 Tax=Corynebacterium pseudogenitalium ATCC 33035 RepID=C2BR76_9CORY Length = 62 Score = 59.0 bits (142), Expect = 2e-07, Method: Composition-based stats. Identities = 16/62 (25%), Positives = 32/62 (51%) Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303 P+ + + ++ +R V A DGS+ + G+ +A +G +++EL GA E+L Sbjct: 1 APVAATSRWDGDQLTVRGGVFALDGSRQLTATASGSAAEAADLGARISDELFAGGAAELL 60 Query: 304 AE 305 + Sbjct: 61 GK 62 >UniRef50_UPI0000D537E6 hypothetical protein P700755_22735 n=1 Tax=Psychroflexus torquis ATCC 700755 RepID=UPI0000D537E6 Length = 356 Score = 55.5 bits (133), Expect = 3e-06, Method: Composition-based stats. Identities = 46/234 (19%), Positives = 83/234 (35%), Gaps = 38/234 (16%) Query: 68 VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127 +L + D+ S D + +GL + + R++P V+N+ + L G+ + Sbjct: 49 QSLRDGAGDLVAMSAFDWQQQDVEGLIIAGLLTRKEPTWVLVANDKP--EYLKQGAYILC 106 Query: 128 S--SLRRQCQLAERRPDLIIRSL-----RGNVGTRLSKLDN-------------GEYDAI 167 LRR Q+ R DL + ++ R N +S+LD G D Sbjct: 107 DHELLRR--QMMRLRGDLTLETMEEMGKRLNAAATISELDEEDIWPWVEGLLKNGNIDGF 164 Query: 168 ILAVA--GLKR-------LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAA 218 I+ A R LGL+ + E +P G + R + + Sbjct: 165 IVPRAIHASHRMKSRRHTLGLQRDNSES-NRERFIPPPLHGFTMLVGRNGFPKAS--IQD 221 Query: 219 LNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQII 272 + L E A+ LE + +G++ E +I + DG + + Sbjct: 222 MVDQSAELAYRLEAAILESLEPSLRPIVGAFVEQR--KIATILKKASEDGDEAL 273 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.312 0.171 0.535 Lambda K H 0.267 0.0525 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 2,502,518,840 Number of Sequences: 3077464 Number of extensions: 137751043 Number of successful extensions: 330475 Number of sequences better than 1.0e-01: 231 Number of HSP's better than 0.1 without gapping: 680 Number of HSP's successfully gapped in prelim test: 7 Number of HSP's that attempted gapping in prelim test: 327984 Number of HSP's gapped (non-prelim): 799 length of query: 313 length of database: 1,040,396,356 effective HSP length: 128 effective length of query: 185 effective length of database: 646,480,964 effective search space: 119598978340 effective search space used: 119598978340 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.0 bits) S2: 94 (40.5 bits)