>ss_pred
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCHHHCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCHHHCCCCCEEECCCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCCEEEEEHHHHHHCCCCCCEEEECCHHHCCCCCCCEEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEEEEEEEEECCCCCEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>ss_conf
9987089983698889999999999999868995289999972084235782677088531179889998839832999331118866799817988605798106999148998788899988802757899999973899699965698899999986689876743147888749975203542866726776652899998089589999987539998999999999999983889988659999998997999999986899879999885178899999999999999830799999876268899
>batch____
MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYNGDAPA
>UniRef50_Q54P93(12-322:325) Porphobilinogen deaminase n=1 Tax=Dictyostelium discoideum RepID=HEM3_DICDI  E=4e-62 s/c=0.77 id=44% cov=96%
-------IGSRKSQLAMLQTEWVRDRIQELNPGIIVEIKTMDTTGDKVLDVSLSKIGDKGLFTKELEDMMLNGTIDLAVHSLKDIPTKLPDGLKLGAITKRYNTSDAFIANAKKhgkncKLSELPQGAMIGSSSLRRVAQLKKAYPHLQFKDIRGNLNTRFKKLedDSNGYDGMILAVAGLERMELTDHISEIIPDSISLYAVGQGSLGIECKDGDDFIQSILNPLIHRESMYCCEAERSMLRDLEGGCHVPIGVVTKLHnqsqpDETLEINAIVLNLDGSKYIESKIIGPSIQYYQLGKSIAQDLINKGSKDILSE--------
>UniRef50_Q0TQG4(3-288:291) Porphobilinogen deaminase n=32 Tax=Clostridium RepID=HEM3_CLOP1   E=3e-54 s/c=0.75 id=45% cov=92%
-----LIIATRKSKLAQVQTEKVME-LLKEKENVDSKKLLVMTEGDRRLDVSLNKIGGKGLFVKEIELALLNKEAHGAVHSMKDVPFELPSEFELVAMPEREDIRDAFVSLNGSTLSNLRKGARIGTSSIRRAEQLKLFRDDLEIVPIRGNVQTRIKKITEENLDGIILAAAGLKRLGMEDVISDYFDPKVFLPAIGQGALGIEC-LKGGEFNDYFKALDSKEVRTTVEAERSFMKVLNGGCHSLIGAYSEVKDNDLYMIGTFTV--NNRIVKKDILGNKEDNILLGKKLAEKIL------------------
>UniRef50_D1CBT4(2-296:300) Porphobilinogen deaminase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CBT4_THET1  E=1e-50 s/c=0.68 id=38% cov=95%
---KVIKVGTRGSKLALWQTQWVINRLRSLYPGFQFEPVVIKVTSDRSPDAPISAIGQVGVFTKDIEQALLAGDIHLAVHSLKDLPTLSTPGTVIAAFTEREDPRDCILWPKGQPMPDL-NNSRVGTSSVRRSALVRSYWPNANVVNLRGNVDTRVRKMLEGNYDVVLMAYAAVKRMDLPVEFK-PLPLDSWVPSAGQGIIAVQAREDDQQIIGMLNAINFFPSKVAYLAERSLMRALGGGCSMPVGAYAELHDGELSLIGMVAAPDGSQVVITRRVDTPDQADHLGERVAREMLDLGIR-------------
>UniRef50_C5RMN3(1-299:300) Porphobilinogen deaminase n=1 Tax=Clostridium cellulovorans 743B RepID=C5RMN3_CLOCL  E=3e-48 s/c=0.65 id=41% cov=94%
-MKKIIRIGTRKSKLALMQTNIVIDAIKKKHPEINCEVVEMSTKGDEILDKSLLSFGGKGAFVSEFEKAIKSGEIDLAVHSAKDMPMDLLTGLKIVAVTKREDPRDVLVTaNNKDTInDFNKTNKLIGTTSLRRKLQIKRLLNNVDTKDLRGNVQRRLEKLISGEYDGIILAAAGLKRLGLldDERINlNYLSVEDFIPAGGQGIIAVEGRAEEEFSF-LKDSIHNEEAMYSLEVERYVMKKLNAGCNEPIGAYS-FIDKDTIFLDIIYEHNGKV-----SRKKGSDSIENRLKLTEKLV----EEILQEV-------
>UniRef50_Q09899(9-322:336) Porphobilinogen deaminase n=2 Tax=Schizosaccharomyces RepID=HEM3_SCHPO  E=1e-47 s/c=0.61 id=42% cov=96%
-------IGTRKSKLAVIQSEIIREELEKHYPHLEFPIISRDTIGDEILSKALFEFKrqlAKSLWTRELEALLVTNQCRILVHSLKDLPSEMPDGMVIACIPKRSCPLDAIVfkaGSHYKTVADLPPGSVVGTSSIRRRALLARNFPHLRFVDIRGNVGTRLAKLDapDSQFDCLVLAAAGLFRLGLKDRIAQMLTAPFVYYAVGQGALAVEVRADDKEMIEMLKPLQHQETLYACLAERALMKRLQGGCAIPIGVQTDVLaisnsSYRISLLGTVLSADGLRAAFGNaeaVVSSEEEAEELGITVALALLKNGAGPILEE--------
>UniRef50_D1VCA1(36-377:380) Porphobilinogen deaminase n=1 Tax=Frankia sp. EuI1c RepID=D1VCA1_9ACTO  E=1e-40 s/c=0.49 id=41% cov=95%
-----LRLGTRRSALALAQSGMVADELR-TRLGIEVDLVHVVTEGDRN-RAEISQLGSTGVWVSALREALLSGEVDLAVHSLKDLPTAPPEGITLAAIPPREDVRDVLVSPTGRTLAQLGPGARIGTGAPRRAAQLRALGLGLDVVPIRGNVDTRIKKAIDGEVDAVVLARAGLARLDRLDAITELLEPEVMLPAPGQGALAIECvattlapltlltvgtpedqgavtgmscpvapgsGVEIPLERLLRFVLDDAPSSVAVRAERAFLAAIEAGCTAPVGALAQVLpargqapasEGEVRLRAVVASLDGTTVLRRELGGSTADPEALGRRLADDLLSAGAHTLM----------
>UniRef50_D1B7N1(8-304:307) Porphobilinogen deaminase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B7N1_THEAS  E=8e-37 s/c=0.53 id=42% cov=92%
---------TRSSPLAMAQARMWKDRIESL--GHSVRLLDVSTHGDRDRRRHLACFGGFGAFVKALEDRLLSGQGHGAVHSLKDVPSVQPDGLVIAGVLERGPRGDVLVTREGLSLEELPSGAVIGTSSIRRAAQVRMLRGDLNVECCRGNVHSRLRKLEQGLFHGIVLARAGLERLGI--RAPMAELPFITSP--GQGAVALEAR-EGSELHLLGARLTHRSTWLEVLAERSFLKAFGMGCSAPVAASAVMDRDTLTLKVQVLSPNGTSAAEAEVSCVPwgeEDAYALGeaafreISGSPEVLSAGsaAREV-----------
>UniRef50_Q2NEP4(3-290:290) HemC n=4 Tax=Methanobacteriaceae RepID=Q2NEP4_METST   E=7e-36 s/c=0.53 id=34% cov=90%
-------VGTRGSKLATTQTKTVVKALEEITGEEIETKI-IKTTGDKIKNSQLYNIDAKGIFTKELDTALIDGSIDFAVHSFKDLPSELNDQLTITAIPQREAINEVLISNY--SWDELPENATLGTSSVRREafCKLHGKK--IQTKPIRGNIDTRIRKVEEGEYDATIMALAGINRLGLQEHIKEVFDEQYITPPAGQGALAVMTH-KDSEYNDVISKLNHEDSRIEAMTEKAILETIGVGCQWPIGIVSKVDGNNINIHCKLLSPEGKLLAdvnkTTDKNNAINTAKVIGTKLREDTL------------------
>UniRef50_Q30Y29(2-312:316) Porphobilinogen deaminase n=13 Tax=Bacteria RepID=HEM3_DESDG   E=1e-117 s/c=1.36 id=54% cov=99%
---KKIVIATRGSKLALWQAEHIKERIMQQYPDsFEVELLVLKTKGDIILDVPLAKVGGKGLFVKEIEEALLDGRADIAVHSMKDVPMELPQGLTLGAIPEREVPTDSLLSARYDGLDALPQGAVVGTSSLRRQSQILAMRPDLEVKWLRGNVQTRIRKLMDGEYDAIIMATSGLKRLGETAPFHSELGPPLFMPAVGQGALGLEYRSDRQDLAEMLAFLDHRPSRICVEAERGFLFGLQGGCQVPIAGYAVMTgDNSFELTGLVAELDGTAVIRRTAAGTEADARDTGLTLAAQVKAAGADAILQRVYeNGHA--
>UniRef50_P08397(19-352:361) Porphobilinogen deaminase n=59 Tax=Chordata RepID=HEM3_HUMAN   E=1e-114 s/c=1.24 id=48% cov=96%
---RVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTKELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPkfvGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEqQEFSAIILATAGLQRMGWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQatihvpaqhedGPEDDpqlvgitarniprgpqlaAQNLGISLANLLLSKGAKNILD---------
>UniRef50_Q2LQU2(1-304:306) Porphobilinogen deaminase n=1 Tax=Syntrophus aciditrophicus SB RepID=HEM3_SYNAS  E=1e-114 s/c=1.36 id=43% cov=97%
-----MKIGTRGSALALTQTRQIAARLQGQYPEMHLEIVVIKTSGDIQKDVPLAKIGGKGLFIKEIEEALLAGTVDLAVHSMKDLPAELPEGLQIAAVPRREDPRDVLISGICREFDNLPAGARIGTGSLRRSVQLRDWRPDLEIVPLRGNLDTRIRKVAQAALDGVVVAAAGIRRMGWAEKVTQFIPTEKMLPAVGQGVLCLETREEDEDLKAGLAFLEDKRTRREVTAERAFLRRLGGGCTLPVAAFAEQRGDVLTIRGMVGSLNERTMIRQEIYGSVEQAVDLGTELAERLLDGGGRILLEHLEDG----
>UniRef50_Q4L709(2-309:310) Porphobilinogen deaminase n=88 Tax=Bacillales RepID=HEM3_STAHJ   E=1e-113 s/c=1.33 id=46% cov=97%
-----LVVGSRRSKLALTQSQQFIDKLKAVDPTLEIEIKEIVTKGDRIVNKQLSKVGGKGLFVKEIQQELFDKEIDMAIHSLKDVPSIIPEGLTLGCIPDREVPFDAYISKNHIPLNELPDGSIIGTSSLRRGAQILSKYPNLEIKWIRGNIDTRLKKLEIEDYDAIILAAAGLRRMGWSDDIvTTYLDKDILLPAIGQGALGIECRSDDVELLELLSKVHNQAVANCVTAERTFLSAMDGSCQVPIGGYATnKENGEIEFTGLIMTPDGTKRYEHTEVG--KNPVDLGEAVSRVLKEQGAYEIIKKLNEEQA--
>UniRef50_A6WXJ2(6-311:314) Porphobilinogen deaminase n=56 Tax=cellular organisms RepID=HEM3_OCHA4  E=1e-112 s/c=1.33 id=43% cov=97%
LKNGTLKIGTRGSKLALAQAYETRRRLMEAHglPEEAIEIIPMSTAGDRIQDRALSEIGGKGLFTEEIEQALTDGRIDLAVHSTKDMPTVLPDGLHLSVFLEREDPRDAFIGRTASRLLDLPQGATVGSSSLRRQALIRRLRPDIQVVIFRGNVDTRLRKLEAGEVDGTFLACAGLRRLGLGDVITDLADPESFPPAPGQGAIGIETRIGDTRIDTLLAPLAHRETGIALACERAFLAALDGSCRTPIAGLATVNGDTVSFHGMILKPDGSEAHEIKTEGPASNAAAIGTEAAEHLRAKAGPQFFE---------
>UniRef50_A5VM67(1-303:305) Porphobilinogen deaminase n=9 Tax=Lactobacillus RepID=HEM3_LACRD   E=1e-108 s/c=1.30 id=40% cov=94%
-MTNKVIVGSRKSKLAMAQTELVIASLEKIFPDIKFEIKNVITEGDRNRHVSLAKIGGKGVFVKEIEDELKDGTIDFAVHSLKDVMPILPEELVLGAFPKRVSPYDCLVSRKNlSSLNDLPKGARIGTNSLRRQGQLLSIRPDLKIIPIRGNIDTRLRKIDTEALDGIILAEAGLTRLNIDLSSYHVLDLQnYIMPAVGQGCLAIECRKNDTRIRKMLDQINDEESAYCVQVEREFMRELGGSCNFPIGGHAYAKNGQILFDGLIASPNGEHVIKETKI--PANNSGVGKKVADQLLAK----------------
>UniRef50_O94048(11-327:340) Porphobilinogen deaminase n=53 Tax=Saccharomyceta RepID=HEM3_CANAL   E=1e-107 s/c=1.24 id=44% cov=97%
--SNHVQIGGRKSKLAVVQSEIVKKVIEDTFPNLSCSILALSTLGDKVQTQPLYTFGGKSLWTKELEILLLDSvdefpKLDLIVHSLKDMPTNLPEEFELGCIFQREDPRDAIVMKQgssYKSLKDLPAGAIVGTSSIRRSSQLIKNYPHLRFESVRGNIQTRLNKLDqpNNEYCCLILASAGLIRLGLGHRITSYL--DDMYYAVGQGALGIEIRKGDDNIKSILKKIEDPIATICCLAERSLMRYLEGGCSVPLGVHSDYNESkqELTLKGIIVSPDGTVSIEDEvikRITCDEDCEQVGIELGDKLKAKGAKEILDKI-------
>UniRef50_C3XEZ5(12-325:328) Porphobilinogen deaminase n=3 Tax=Campylobacterales RepID=C3XEZ5_9HELI  E=1e-106 s/c=1.23 id=48% cov=97%
--EKPLVLGTRGSLLALWQANHIKEKLESL--GFQVVLKTIKTKGDKILDAPLAKIGGKGLFTKELENELLSGGIDFAVHSLKDVPIAIPPELMLVSITQREDARDCFVSEKYADIASLPQGAKVGTTSLRRSMQLKRIRQDLDTQSLRGNVQTRLEKLRKGEFDAIILASAGLNRLDLKDDIGFIshLQINQFIPAMGQGSLGIECRDpkyspdfRDQAIMKVLESLHDSKSALCCNIERAFIQLLGGGCQSPIGIHAQILDSkEIEIQCVVGNLDASKVLTETRVCNKGEVEYALQDMINTLKKNGVMEILEEVRT-----
>UniRef50_A9A1A1(4-297:311) Probable porphobilinogen deaminase n=3 Tax=Thaumarchaeota RepID=HEM3_NITMS  E=1e-106 s/c=1.32 id=36% cov=94%
-------VGARGSQLSVAQTNLVIAELKKAHPDTEYEIKTITTKGDTD-SRPLFTIDQKGIFEKEIDRAVAQKEVDFAVHSLKDVPSELDDNLVLACIPKRETVNDVFISPDGSTLDSIKPGSVIGTSSLRRAVQVSRKRPDVTVKPIRGNIETRIKKASGENYDAIVLAKAGISRLGVDVKYTE-LSTDDFSPSPGQGAIAIVARADDSKTIEMLKKIEDPDSRLEIEAERALSDFVDSGCRFPVGAYAKSNGSEMTLTVTAFSVDGKQFLHVSKTGDKNNPKSLGQSAGEELREKGVNDL-----------
>UniRef50_Q4HT06(2-303:308) Porphobilinogen deaminase n=1 Tax=Campylobacter upsaliensis RM3195 RepID=Q4HT06_CAMUP  E=1e-104 s/c=1.26 id=50% cov=96%
---KKLIIATRKSPLALWQSEFVADILRKTH-GIEVHLEGFSTKGDILLDSPLAKIGGKGLFTKELENAMLENKAHLAVHSLKDVPSFLPQGLVLAALSVREDDTDALLSELYKDLNALPQNAKVGTTSLRRKMQLLSLRPDLHIINLRGNVNSRLKRLKGGEFDAIILASAGVKRLGLESEVKfiYRFSKDELVPAATQGILGIQS-PDKNEILTLLQCLNDEKSLIESTVERDFIRTLEGGCQVPIGINAELMGEQITVRSILGLPDGSEILRDKRIILKKNYQGFGERLALEFIKRGAKELLKR--------
>UniRef50_C3WGN0(1-300:301) Porphobilinogen deaminase n=5 Tax=Fusobacterium RepID=C3WGN0_9FUSO   E=1e-104 s/c=1.27 id=41% cov=96%
-MKRHVVIGSRGSILALAQASLVKNSLEANYPDLTFEIKEIVTSGDKDLKSNWenSNASLKSFFTKEIEQELLDGQIDIAVHSMKDMPAVSPKGLICGAIPDREDARDVLISKNG-FLVTLPQGAKIGTSSLRRVMNLKAIRPDFEIKHLRGNIHTRLKKLETEDYDAIILAAAGLKRTGMADKITEYLSGEAFPPAPAQGVLYIQCRENDEEIKGILKSIHNEDIAKIVEIEREFSKIFDGGCHTPMGCYSQVDEDKIKFIAA-YSHDGKQI-----RVVIEDDLTKGKEIAH----MAAEEIKAKINKGN---
>UniRef50_Q1V167(1-300:307) Hydroxymethylbilane synthase n=3 Tax=Candidatus Pelagibacter RepID=Q1V167_PELUB  E=1e-100 s/c=1.22 id=37% cov=95%
MKNRKIIIGSRGSKLALIYAEKAREKILKHSKDFGIEeviIKEIVTKGDQVQDKRLSEVGGKGLFSKTIEVELLEKKIDIAVHALKDMPSEETRGLLTDCFLERNDPREILISKDNKHLKDLASNSIIGTSSYRREFQIKKIRDDLNCKLIRGNVDTRIRKLKENLYDAIILSYAGIDSLGLNQNISQTFSTSEIIPCAGQGVIALQCRDNDESLIELLKQVDHQSTHSSIKAERNVLKVLEGDCETAVGAFANIEGNKINLEVELFSLDGSKRFYLKSSESVDKAEELGIEMGKTLKKM----------------
>UniRef50_C1ZK04(3-317:318) Porphobilinogen deaminase n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZK04_PLALI  E=1e-99 s/c=1.16 id=46% cov=96%
----VLRIATRASQLALWQANFVADSLRSLDPELTVELVHVTTTGDRVQGEPLRQFGGQGVFTREVQAALLEGRADIAVHSLKDLPTVPTAGLELAAVPARAPVADALLLPTGhsgpASLAMLPRGARIGTGSPRRQAQLLRIRPDLVCSEVRGNLDTRIRKLDAGEYEGLILAVAGLSRLGWSDRISLILAPPTMFPAAGQGALGLECRHGDEATIRWVSQLEDRQTRLAVDAERAVLRTLEAGCHAPVGTWASWKSpETLHLEAILIAPDGSETLAAasSMQGPLSQygsgnaldaAHELGANVAHLLLKQGASRYL----------
>UniRef50_A3ZKX4(4-301:308) Porphobilinogen deaminase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A3ZKX4_9PLAN  E=1e-99 s/c=1.22 id=45% cov=95%
-----IRIGTRGSQLAQWQANWVADQLRAV--GTDVEIIHIATQGDVTQG-PLDLIGGRGVFTTEIQAALLDNRIDVAVHSLKDLPTEAVVGLRLAAVPARGADGDVLITSKASDVLGLPQESIIGTGSMRRKAQLLHLRRDFQIRDIRGNLDTRLRKLDDGLYDAIILAEAGLRRLELIERIRHVIPKAQMLPAVGQGALGLEIRERDSATAAMLAPLNHEDSHYSVLAERSMLRNLRGGCLAPVGAWGRIDpiKQLLFLDGVVVSGDGHHKVTASACGPPNRAEDIGRQVADQLAIQGAERLIA---------
>UniRef50_UPI00006CBE06(16-353:362) porphobilinogen deaminase family protein n=1 Tax=Tetrahymena thermophila RepID=UPI00006CBE06  E=5e-99 s/c=1.07 id=41% cov=98%
LKNRKFKIASRSSQLALSQTYEVIDLLVGvKELGLTkenFEVVPIsnapgknctlkfkinitnkqfTNKGDQNLKDPLYVMGGVGVFTKIVEVELLNKNGDIAVHSLKDLPTIIDERLFIGAVPPLKPRGDVVIfneKHKGKELKDLPEGSVIGTSSLRRITNLKNRYPHLKYENIRGNLNTRLTKLENGQYDAIILAEAGVFRLGWIEKVGQFLKQEDFLYAPGQGALGVQCRADDKEAIALLSYINQKEPRIRVDAERQFLNKLEGvilGCKLPIAVHSEIIDQTLRLTGQVWSLEADKTIREVIEGHISD-QDLGLKLSEKMKQAGAGEILEKIRS-----
>UniRef50_Q82P95(8-313:314) Porphobilinogen deaminase 2 n=14 Tax=Actinomycetales RepID=HEM32_STRAW  E=5e-98 s/c=1.18 id=41% cov=97%
---ELIRIVSRDSPMALAQVARVRAELAALHPRTRTEVVAVKTTGDKWMGD-LSKVDGKGAFTKEVDAALLAGEADLAVHCVKDVPADrpLPAGTMFAAFLKRDDIRDALVHPGGLTLDELPPGTRIGTSSVRRVAQLAAAYPHLECVPFRGNANRRLEKLAAGEADALLLAVSGLERIGREDVITEVLEPETMMPPIGAGILALQCREGDTGLIETISELGDPGTHREATAERMFLHVLQGHCNSPIAGYARTErNGELSLRASVFTLDGKTVLNAHEWAGRLDPATLGTSVAVALLRQGARELIDDIP------
>UniRef50_C7NFP7(14-337:358) Hydroxymethylbilane synthase n=7 Tax=Actinomycetales RepID=C7NFP7_KYTSD  E=6e-98 s/c=1.11 id=45% cov=94%
---RVVRLGTRRSDLATTQSTHVADALRAR--GHEVELVLVTTEGDVNR-APLSRIGGTGVFVSALRDALLAGEIDIAVHSLKDLPVAQPQELVIAAVPEREDPRDALVARDGLTLETLPAGARVGTGSPRREAQLRVARPDLEVVDLRGNVPRRLATVAEGELDAVVLAGAGLRRLGLTEHVTQWLEPQVMVPAPGQGALAVECRSDDAESIAMLEPLDHLPTRTATTAERAVLGTLEAGCSAPIGALARHDGARVDLMTFAGPRDGSRALleadcargvpaghpadtpddtpadtpddsrNDDRVALDTAARELGRRVAEALRGGGAD-------------
>UniRef50_B5G8F1(1-313:314) Porphobilinogen deaminase n=1 Tax=Streptomyces sp. SPB74 RepID=B5G8F1_9ACTO  E=1e-97 s/c=1.14 id=42% cov=96%
-----MRIGTRSSPLALAQVEQVSGLLRKFEPDLDIEVVPVTTKADKWQGD-LAQLGGKGLFVREIDQMLQRGQVDMAVHCMKDVPGDvpMPRGLIFAAYLPRDDVRDVLLVPEGsdvQSLAGLPPGASVATSAVRRKAQINRVRPDLNVVRVRGLVGSRIDKLDGRKpmdhmLDAMVLARAGLERLDLMHRARQVFEVAEMLPAVGAGALGLECREDDDAVAYLLQQLNDEPTMTEITAERVMLHGLRGHCNSPIAGHCVTDpDGQLSLRGMVFSRDGSKFVHAHFWGeSMNDPAVLGSRVCAELLRQGARDIIEGIP------
>UniRef50_A4CHM3(1-311:315) Porphobilinogen deaminase n=4 Tax=Bacteroidetes RepID=A4CHM3_9FLAO   E=4e-95 s/c=1.13 id=41% cov=96%
-MSRALRIGTRDSELALWQAQTVRDRLEAA--GHRAELVPVKSTGDLVLDKPLYELGITGIFTKTLDVALLREDIDLAVHSMKDVPTALPEGICQAAVLERASARDVLVHKGLGFLDG--PG-TIATGSLRRKAQWLNRYPAHQVTGLRGNVNTRLKLLRENSWDGAIFAQAGLERIGLLPDNAEPL--DWMLPAPAQGAMLVVARTSDTAAREAARPLHHEQSALEVAVEREFLRTLEGGCSAPIGARVHAADGQLHLEGGLFSLDGKKAFRVTRhTGSLEaggtgdarfqDAGEFGAACAREILDSGGAVLMESIRK-----
>UniRef50_A0DD68(1-304:306) Chromosome undetermined scaffold_46, whole genome shotgun sequence n=2 Tax=Paramecium tetraurelia RepID=A0DD68_PARTE  E=5e-94 s/c=1.14 id=42% cov=96%
-MQRQLRIATRSSALAMAQTNYVISELKQ-----ECEIIKVSNEvGDVNLQDPLYQMPTVGVFTKQVEQYLLEQKADVAVHSLKDLPTIIDAQLHLAAYTKFEQRGDVVLLNKkynYKSLSELPDGLKVGTSSLRRIATIRSRYPKLNLINIRGNLNTRIQKLDEGQYDAIILAKAGILRLGLAEKISFDLDEKEFLYAPAQAALGIQCRKDDLETIGRLQILNDTDAQKRCVAERMFLNLLEGGCRLPIAVYSECrEDGQVYIKGRVLAVDGSKVIEDE---ALDHFEIVGQILCEKIKVLGGVELIESLK------
>UniRef50_D0J8N1(1-302:310) Porphobilinogen deaminase n=2 Tax=Blattabacterium RepID=D0J8N1_BLASP  E=1e-93 s/c=1.14 id=33% cov=96%
-MNKIIRIGTRNSPLAISQAIEVQKVLHRL--GYCSHLFFIKSEGDLIQNIPLYKFKKVGIFTRNLTDVLLSGKIDMAVHSLKDVPTSLPEKIVLSAYLKRGSFSDLLIYQGSSNfLLNSKIEAVIATGSLRRRAFWKNRYPHHTIVDLRGNINTRLKKLYNNSWKGAIFAKVGLERLGLLNDLEGFNFkvLDWMIPSPGQGIIVVSTRKDNEWIHYLTKELDDRNTRLSANIERQFLKTLGGGCVTPIGAHAIIKNKIIYFTGILFSLDGMQKIRKKKIGT--NYNVIGYQCAKEILEEGGKKILE---------
>UniRef50_C2GGB5(2-289:290) Porphobilinogen deaminase n=2 Tax=Corynebacterium glucuronolyticum RepID=C2GGB5_9CORY  E=1e-93 s/c=1.20 id=42% cov=92%
----TLRIGTRGSKLATTQAGHVRDALIRA--GYDAELTIITTPGDKNL-SPVQKIG-VGVFTQALREAMDRDEIDIAVHSCKDLPTGQPEGLATI-YPVRETPCEALIARDGLTLDQLPEGAKVGTGAPRRISQLKALRPDLDIRPLRGNVDTRMGKVTSGELDAVILAHAGLTRIGRGDEATQVFDPTYLMPAPAQGILAVESRTHVDAISTL---IDDHAT-LSAQAERAVLSTLQAGCTAPLAAYSTVSGDEITLTAGAFALDGSKQIVETATGT--DPVALGTSVAEKLRACGAEEII----------
>UniRef50_C5RMN3(1-298:300) Porphobilinogen deaminase n=1 Tax=Clostridium cellulovorans 743B RepID=C5RMN3_CLOCL  E=8e-92 s/c=1.14 id=39% cov=94%
-MKKIIRIGTRKSKLALMQTNIVIDAIKKKHPEINCEVVEMSTKGDEILDKSLLSFGGKGAFVSEFEKAIKSGEIDLAVHSAKDMPMDLLTGLKIVAVTKREDPRDVLVTaNNKDTINDFnKTNKLIGTTSLRRKLQIKRLLNNVDTKDLRGNVQRRLEKLISGEYDGIILAAAGLKRLGLldDERINlNYLSVEDFIPAGGQGIIAVEGRAEEEFSF-LKDSIHNEEAMYSLEVERYVMKKLNAGCNEPIGAYSFIDKDTIFLD-IIYEHNGK-VSRKKGSDSIENRLKLTEKLVEEILQE----------------
>UniRef50_C2FZW8(1-298:528) Porphobilinogen deaminase n=2 Tax=Sphingobacterium spiritivorum RepID=C2FZW8_9SPHI  E=1e-90 s/c=1.12 id=39% cov=92%
-MNRKLIIGTRGSQLAMWQANHIKDRLAAA--GIDSELKVIKTQGDIIQHLRLDKLEGKGFFTKELEEELLSSTIDLAVHSHKDLPTVNPPGLIIAAVSERESPAELLIVLKDcvdiKKRLSLKHNATVGTSSNRRKAQLLSLRPDLEFDDLRGNLQTRIQKLRDENYDAIILAKAGVERidMDLSDFYVEEIPPVELIPAPAQGVLAIQIRESDQELFEALQVIHNKEVAEVIAVERKVLNLFDAGCHAPLGCYCRKSEGKYEAWTSVAEtsdefPDRLYIQRDSTEG-----------MAEEIFTKFAKD------------
>UniRef50_C9RPT6(1-344:351) Porphobilinogen deaminase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RPT6_FIBSS  E=2e-90 s/c=0.97 id=45% cov=93%
MSDLKLRIATRKSALALAQTTMAADAIVAANSvignaadsnnardSLTYELVSMTTEGDRRLDKSLASFGGKGVFIKELEIALLEGRADIAIHSLKDMPAEVLPQFKLAAVLKREDPRDAFLSRGGSagiRFMDLPAGARVGTGSIRRVVQLKALRPDLEYVPIRGNIQTRIGKLA--ELDGVVLAAAGLKRMGLADQVTEYFSTEQMLPASGQGILAIETLNDatvqesrvtgRADLAQILARVNDVATYCIASAEMAYLKALNAGCQFPVASFAEFvcEDGienrgtcgaleenanriaqTLKIRGIYWDEKSEKLLRAEVAGnvdlnsedCVQQSKNLGIELA----------------------
>UniRef50_A4WN24(3-291:297) Probable porphobilinogen deaminase n=3 Tax=Thermoproteaceae RepID=HEM3_PYRAR  E=4e-87 s/c=1.12 id=38% cov=92%
-----LVVATRGSKLSMLQTEELLAQIKAVEPSIEFEIKIVKTTGDEVQDKPLYQIGVKGIFEKEVNLAVLRGEADVAVHSLKDLPSELSPGLVLAGFSKRAPPFDAVVSTAGYVLETLPRGALVGTSSVRRAEFVKAIRPDVRVEPLRGNVDTRINKILQGKYDAAIMAVAGIYRLyGASPPIKlAVLRPEVLPPPPGQGIVAAVVREADSWLIDLLKKASDPKASLEAIAEREFLKAVGAGCHVAIGGVAFARNDTVEFIAGYAS--GGRKYIVRVVG--DDPVEVGRRAAEEIRK-----------------
>UniRef50_C4JRY9(7-281:287) Porphobilinogen deaminase n=1 Tax=Uncinocarpus reesii 1704 RepID=C4JRY9_UNCRE  E=1e-86 s/c=1.17 id=41% cov=83%
---KTYTIGTRKSPLALVQTDLVRRALQTAYPN-----------------------------------------CDLKVHG--HVPTQIPDACVLGAMMPRENPRDVLVIKKGlpwMTLAELPAGSVVGTSSVRRTAQLARHYPHLVVQDIRGNIDTRLAKLDaeDGPFTCLIMAAAGLLRTGHENRVTQYLDSKNgkMLHAVGQGALGIEVRTDDEVMKDMVNKIGDMPTTYACMAERNLLRTVEGGCSAPLGVETEWIQDDngkslLRLRAIVVSVDGKEAVELEKDGdveSIEEAEAFGKQVALELIDKGAGKILEEI-------
>UniRef50_A9HK97(46-366:367) Porphobilinogen deaminase n=12 Tax=Acetobacteraceae RepID=A9HK97_GLUDA  E=5e-85 s/c=0.98 id=44% cov=96%
----PLRVGTRASPLALVQTRAFLTMLTRFCPVLRdmgaFQEHQINTTGDQVQNRRLAEIGGKGLFAKEIHDALSDGRIDFAVHSLKDLETTLPPGLVLACTLRREDARDALILGPGAGGRHdaadaadpyaaLPRNALVGCASVRRQAQMLHVRPDLRFGLLRGNVQTRLDKLAARQCDATLLALAGLRRLGMEDRADIVLDPEIMVPAAGQGIVGVTVRESDVELRELLAAIEDYEARAVATAERALLAELDGSCRTPIGGYARLVPGlagaeaSLRLTGLVAREDGSFLLRRTVTGLRADAEEMGRELGRSLRMDSPSDVFA---------
>UniRef50_C0W553(2-386:402) Porphobilinogen deaminase n=2 Tax=Actinomycetales RepID=C0W553_9ACTO  E=3e-83 s/c=0.81 id=43% cov=95%
---STVRLGTRGSALALTQSGLVARMLEQAAAlagqELHVELVPVRTRGDVD-PTALSQLGGVGVFATALREALLAGECDLAVHSYKDLPTAAVPGLRIAAVPAREDPRDVLCTRAATlGLHDLPAGARVGTGSPRRSAQLLAQRPDLTIVPIRGNVPTRLARVvgsvvsadgpmgatAEPDLDAAILALSGMRRLGLEDYASQPLaarcgarsqvevqgipdggsaagspatTEPWMLPAAAQGALAVETR--DRVSCELpvltvaLALVDDPVTRACADAERSLMRCLAAGCAAPVGALARPLDvagepaagrdlptepgtalepgpdqaPAICLEALVASLDGTQLRRASATGTLEEAEDLGRCVAERLLADGAAQI-----------
>UniRef50_Q6L2G8(3-249:282) Probable porphobilinogen deaminase n=1 Tax=Picrophilus torridus RepID=HEM3_PICTO  E=1e-82 s/c=1.25 id=43% cov=77%
-----IRIGTRSSKLAMIQAMMVKDRLDSL--GIETEVKGFTSKGDINLDSPLYSIGGTGVFVDDLNRMILKNEIDIAVHSAKDIPSFIDDSLEISAVLKRDDPRDVLISQH--SLNDLEASSVIGTSSLRRIKELKTLRNDILIKDLRGNIDTRLKKLDNGDYDGIIMAKAAYDRM-RINRRHFILNYDDFVPAPNQGIIAI-ISKKDSEINDVLKKINDDETYNDMKAERLILSGLNLGCSKPVGIYAH--------------------------------------------------------------
>UniRef50_C3MZR8(3-285:293) Probable porphobilinogen deaminase n=11 Tax=Sulfolobus RepID=HEM3_SULIA  E=2e-82 s/c=1.09 id=35% cov=91%
-----IRIAARGSKLSRIQVDMLGEKLKKI--GIEYEIIDIKTKADLFSTEPLSKLG-KGVFEKEVNEAVLEGKADIAVHSMKDILSEINPSLEIFAVLERDPPYDILIAEK--NLDKLDSNITIGTSSIRRKNFLKYIKPEINTKDIRGNVDTRIRKYLSKEYQGLILAEASLKRLNMTMNY-HRLNVYDFTPEANQGIIVALGRKKDEKIKEIFKEINHKDTLDEALAERAVISLVGGGCHSPIGVLFKKEGKEFY--GIASYSDGKKKITVSIS-KPGDPYTIGSELGLLLKKE----------------
>UniRef50_A6LKX0(3-243:279) Porphobilinogen deaminase n=1 Tax=Thermosipho melanesiensis BI429 RepID=A6LKX0_THEM4  E=4e-82 s/c=1.27 id=39% cov=77%
-----IRVGTRKSKLALIQTQLVVNKLKELLPNIDFEITPVVTKGDR-LKTPIDKIGGKGVFVSDIEKLILDDKLDIAIHSMKDLPSKIPDKLFLTSVLKRECPNDVFIGKE--NFFNLKKGAKIGTSSKRRALQINMLRPDIEIVPIRGNVDTRIKKI--GELDGIVIAAAGVIRLGLKDKITNLFEFEKIVPAPCQGILALEFSEKFLKPFEEIKdVIVDPKTEVETQIERKILSLLNFDCNTPFGFYC---------------------------------------------------------------
>UniRef50_Q18ES3(10-377:394) Hydroxymethylbilane synthase (Porphobilinogen deaminase) n=9 Tax=Halobacteriaceae RepID=Q18ES3_HALWD  E=2e-81 s/c=0.83 id=39% cov=96%
----TLTLATRGSDLALKQATSVQEALTDER--YEVDLIEVETRGDQIQDELIHQLGKTGAFVRALDKKVLDptAEADAAVHSMKDMPTDSPDDLVVAGIPQRAPPGDLLITTDGQRLSDLPSGATIGTSSLRRQAQLLDQRTDITVEPLRGNIDTRIEKLlapslqteheqrieaEQGeitntentgsddedidrdetdkelpefeqsieawfnelseierralersvetEYDAIVLAEAGLQRSGLIHHIEYVqLDTTTFVPAPGQGAIAITTQGEANATAQIREAIDHPRTRVETTVERTVLAELGGGCIAPIGVHATLQGEYVHVAAQVFASDGTETVDGSRNLPVDAHADAAAQFANKLADRGADELIA---------
>UniRef50_Q0RS16(36-399:402) Porphobilinogen deaminase 1 (PBG 1) (Hydroxymethylbilane synthase 1) (HMBS 1) (Pre-uroporphyrinogen synthase 1) n=2 Tax=Frankia RepID=Q0RS16_FRAAA  E=7e-81 s/c=0.83 id=41% cov=93%
------------SALALTQSGMIAAQLRERV-GCAVDLVPIVTAGDR-SPAEISQIGGTGVFVSALRDALLAGEIDLAVHSLKDLPTATPPGLVLAAVPTREDTRDVLVSPSGRGLAALGPGARVATGAPRRAAQLRALGLGFDVVAIRGNVDTRLKKAIDGEVDAVVLAYAGLARLDRLDAVTEILDPEVMLPAPGQGALAVECAAEaglrlagparalvaagagdhadgdrpgaeagrdgrgrgpdvgrnsgqtrsdhgqplDGGLAELLRfVLDDASSSVAIRAERAFLAGIEAGCTAPVGALAVAEPapaaavgtvapagdaspaGRLRLRAVVAAPDGSTVLRRDVTGSAVDPEALGQRLADDLLSAGAHSLM----------
>UniRef50_UPI0001C31A39(2-282:314) porphobilinogen deaminase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31A39  E=3e-75 s/c=1.01 id=47% cov=89%
---SVLRIGTRASALALVQAEHVASLLR--DGGAQVEVIPITTSGDRGR-----LLGDKSRWVKELEAALLADEVDVAVHSAKDVPAELPDGFVLAGVPARADARDALCG--AASLEQLPDGAVVGTSSLRRAAELRALRPDLGVVALRGNVDTRLRKLADGQAAAIVLAVAGLERLDRGAAIGAVL--DQLVPAPGQGALALETRADDDRARAAAAAITDADAAACLAAERALVRRLGATCHTPLGAHAvRTADGGLRLRSFVGLPDGSAWLRDELSAAAGiDPETFGVAAG----------------------
>UniRef50_A7BMK1(1-211:211) Porphobilinogen deaminase n=1 Tax=Beggiatoa sp. SS RepID=A7BMK1_9GAMM  E=2e-73 s/c=1.32 id=59% cov=67%
----------------------------------------------------------------------------------------------------REEPFDAFVSNTYATLAALPEGAIVGTSSLRRQSQLLAHRPDLQIRSLRGNVGTRLSKLDNGDYDAIVLAAVGLKRLGLVERIREIIDSTIMLPAIGQGAIGIECRQDDLETRQHIDNLNDPDTQDCVIAERALNESLEGGCQVPIAGYAEIQSSEnLTMRGLVGDIEGQHILRHNLQGARHLAAELGKSLAKVLLTQGAAQILEKLKD-----
>UniRef50_A8I2X7(60-362:380) Porphobilinogen deaminase n=1 Tax=Chlamydomonas reinhardtii RepID=A8I2X7_CHLRE  E=4e-54 s/c=0.71 id=37% cov=87%
--QRPLVIATRPSKLAKEQTRQVQQLLLAAAQLKDEQLqlstLELASRGDTTQGVSLRSLGS-GAFTEELDQAVLSGAADMSVHSLKDCPAALAPGLLLAACLPRADPRDVLIAPEATSLGELVPGSRVGTSSSRRAAQIKHSFPHLQVVQLRGNVDSRLGRIRSRDIGATVLAAAGLKRLGVMNSDEGDTTAT--------GAVGVVCRADDEWVVGLLDAISHRGTALEVAAERACLAAllggggacqrsafpdIAWACHT----RHDPDSNTMDLDCLVADLEGKELFRYTEfyrpVIDEVDAVSLG--------------------------
>UniRef50_B6YQR9(11-225:682) Hydroxymethylbilane synthase/uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YQR9_AZOPC  E=2e-53 s/c=0.98 id=39% cov=65%
-----LRVISRNSPLSLLQVKEV----FSFFPNIDYQLITIESFGDKNKHVALFDISNVSsffleeesisdFFTRELDEALIYNKADIAVHSAKDLPYPLPYDLELFALFQAMDKSDSLISRNNLTLEQLPPRARVGTSSQKRKTELLKIRPDLEVVSIRGNIEERIAKMDNGFIDALIVATCALIRLGMEARIACILPFET--HSL-QGNLAIVGRKNDKNVKNLF-------------------------------------------------------------------------------------------------
>UniRef50_Q6MHU0(3-288:502) Hydroxymethylbilane synthase n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MHU0_BDEBA  E=5e-53 s/c=0.73 id=33% cov=77%
-----LRISARKSDLARLQAYMVGDALKEKNPQIEIDYRFRESLGDKNLTDPLWKIPEKGVFTEDFFGELLRDETDLVVHSWKDLPTEHKSETVIAATLPRADQRDLLLVKK-SHFDKIKTSKtlKVFSSSPRREYNLtgffKEHLPfglqDVKFESVRGNMLTRVRKLiESPETDGLIVAKAAFDRlfsatlpefLEGQQQLRQYfnelnwvvLPLSVNPNAAAQGALAVEVLKSRQDLQDLLQSIHHADTFHCSQKERDVLSSFGGGCHQKIG------------------------------------------------------------------
>UniRef50_UPI000155526F(90-211:218) PREDICTED: similar to hydroxymethylbilane synthase n=1 Tax=Ornithorhynchus anatinus RepID=UPI000155526F  E=2e-42 s/c=1.43 id=50% cov=36%
--------------------------------------------------------------------------VDLVVHSLKDLPTVLPPGFTIGAVCKRESPYDAVVFHPkhvGKTLATLPEKSVVGTSSLRRAAQLQRKFPHLEFKSIRGNLNTRLRKLDElQEFSAIILAAAGLQRLGWQSRLGQV-------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI0001742E92(1-113:119) Porphobilinogen deaminase n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI0001742E92  E=2e-28 s/c=1.14 id=28% cov=36%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSEYFDTDFFMPAPGQGILCIQCRENDNKIRHLLEIINDDEVTMMCEAEREFSKIFDGGCHTPIGCSSVIEGDTLKLKGM-FNDNGSRMLK-EVEGNKENPKEIAQKLAEEIKKE----------------
>UniRef50_UPI0000D9FBB5(5-98:105) PREDICTED: similar to lethal (3) 02640 CG9165-PA n=1 Tax=Macaca mulatta RepID=UPI0000D9FBB5  E=2e-18 s/c=1.01 id=36% cov=30%
--NATLRIGSRRSDLARLQTLMVADRLEEM--GYKVVLVGM---------------PETGVFTTFLRQKLLDGSVDLVVHSWKDLPLAEEAGTTVAATLPRADPRDLIIIRK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI0001C35DE1(14-121:121) porphobilinogen deaminase n=1 Tax=Clostridium hathewayi DSM 13479 RepID=UPI0001C35DE1  E=1e-14 s/c=0.77 id=23% cov=35%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HYFACEAFIPAGGQGILAVEGRIED-RICEMAVRIQDEDAKTCLMLERKILKLLDAGCHEPVGVYSRIRGEEIEVFGI--SRRDRETKRVYLTGGIGELDLLAERAAKGLR------------------
>UniRef50_C5U771(2-84:89) Porphobilinogen deaminase n=1 Tax=Methanocaldococcus infernus ME RepID=C5U771_9EURY  E=3e-10 s/c=0.82 id=30% cov=26%
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKINDKKTFLETTAERKALNELGCGCHVPFGAFAKYEGKRLMLKVAVANKDRVIKKESSICCEVDEiekAEKLGESLGRELRR-----------------
>UniRef50_Q2RJ26(4-308:313) Porphobilinogen deaminase n=5 Tax=Clostridia RepID=HEM3_MOOTA   E=1e-111 s/c=1.32 id=49% cov=97%
-----IKVGSRESELARWQARWVIQALEKAWPGLSCRLVTLKTKGDKILDVALARIGDKGLFTKELELALLDGAIDLAVHSMKDMPTTLPEGLVIGAIGPREDPADVLVSPEGYTLATLPIKARVGTSSLRRKAQLAYARPDLELVDLRGNVPTRLAKMERDGLTAIVLAAAGLKRLNHGQVLGEPIPYHICLPAVGQGAIGVEIRAGDRRVAELVAAINHPPTAAAVRAERAYLRALEGGCQVPIAALATVEDTALVLQGMVASLDGREMLRDIASGSTRDPEAAGRELARKLLARGAGEILQEVKA-----
>UniRef50_B2A1G7(3-311:311) Porphobilinogen deaminase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=HEM3_NATTJ  E=1e-110 s/c=1.29 id=45% cov=97%
-----LRIGTRRSQLALDQTNWVVEQLKTHYPDIEIEIKKIETKGDQLLNVSLSKVGGKGLFLKEIQNALLQGEIDLAVHSMKDIPTETTEDLEICAITKRVDPLDALISNNDITIDELPENAKIGTSSLRRGSQLKAYRNDLQIIPIRGNINTRMNKLQElPELDAVVLAKAGLVRSGMTDSISQNISPEIIVPCPGQGALGLEIRHDNENLKEKLAVLDDSESRKAIGAERAFLNRLGGSCHVPVGAYAEIISNELHLTGVVASEDGQDVIKRSVQTHLSDnnkiPSTLGNDLAEELIELGANKILSELKEG----
>UniRef50_B3E2H7(1-309:312) Porphobilinogen deaminase n=3 Tax=Proteobacteria RepID=HEM3_GEOLS   E=1e-108 s/c=1.27 id=52% cov=98%
MAPKRLRIGTRASQLALWQANWTKSELEARYPGIQVELVKIKTMGDKILDVPLAQVGGKGLFVKEIEEAMLRGEIDLAVHSMKDVPTEFPEGLGLVVTTKREDPRDAFIS-DKVTFSELRQGARIGTSALRRQAQLLKARPDLEMVIIRGNVETRIRKLKEDNLDAVILAAAGLNRLGFTDVVTELLDTDFSIPAIGQGALGLECRLDDNATIEALAFLNHADTAAAVAAERALLKRCEGGCQVPIAAHGTVSGDTLTLVGFIASVDGKQTVRDRISGSTADAVKLGTELADRLLAAGGKAILEDVY------
>UniRef50_A7NKU8(1-302:303) Porphobilinogen deaminase n=5 Tax=Bacteria RepID=HEM3_ROSCS   E=1e-106 s/c=1.28 id=50% cov=97%
-MRNSLTIGTRASKLALVQTHMIRDALQAAHPGLTVAVERITTRGDIILDRPLNAIGDKGLFVVEIEEAMRAGRVDLAVHSAKDLPSTLPPDMTLAVCPRRADPRDALVAQPGMTLASLPHGARVGTSSLRRACQLRALRPDLTLLDLRGNVDTRLRKLREGQYDAIVLAAAGLKRLGLEEVITELLEPDVLIPAVGQGIIGVEARAGDDEVLRLLAPLDDPAARAAITAERAFLARIGGGCRVPVGALALLEGDELLLYGMIGALDG-RMVRGMRSGSASDPAGLGSALAEELLDAGGQALLA---------
>UniRef50_Q1J288(2-305:309) Porphobilinogen deaminase n=5 Tax=Deinococci RepID=HEM3_DEIGD   E=1e-106 s/c=1.27 id=43% cov=96%
---RTVTVGTRGSALALAQTRWVVARLKEEWPDTDFRIQTISTKGDRDRAalQSLAQKGDKGFWVKEIEDALLAGRIDIAVHSLKDLPTEQPEGLEIASIPKRVDARDVLIGKDGmKRLEDLPSGARVGTSSVRRKAFLRAYRPDLQILDLRGNIDTRLAALGTPDYDAIVLAAAGLIRTEMRHRIDEFIDPDLLLPAPGQGALALETRADDDLSIEVVYAIHDHATDDRVTAEREFLAGLGAGCMAPVGAHATLKDGVLTLEGWVGALDGSQVIRATTSGDPAECADLGAELAADMLGQGAQQLIE---------
>UniRef50_A8PKX6(4-308:311) Porphobilinogen deaminase n=2 Tax=Gammaproteobacteria RepID=A8PKX6_9COXI  E=1e-105 s/c=1.26 id=50% cov=97%
--KKFLRIATRKSPLAYWQATSIKNQLEKIFPFLKITLLPFVTEGDRPSH-SLNQWGGKGLFVKELEAALLHGQADIAVHSLKDLPMTLEKGLVLGAICKRCDPRDVLISRSDRLFTQLPPGSYVGTSSLRRQSQLLALRPDLKIGVLRGNIGTRLNKLAAGEFDAIILAAAGLIRLKKTECISEYFEIDHFLPAPGQGALGIECHENDEESLTYISALIHPITHSCVLAERALSRELGGGCQVPLAAYAASLGQDfIRLQAFVGSSDGTTQIKVEKQGPRVEAEKIGFLAAQDLRALGVEEILNK--------
>UniRef50_B2S842(8-306:314) Porphobilinogen deaminase n=38 Tax=Rhizobiales RepID=HEM3_BRUA1   E=1e-105 s/c=1.28 id=45% cov=95%
--NGTLKIGTRGSKLALAQAYLTRRLLQEAHglPEDAIEILPMSTAGDRIQDRPLSEVGGKGLFTEEIEQALKDGRIDIAVHSTKDMPTALPEGLHLSVFLEREDPRDAFIGRSARRFMDLPQGATVGSSSLRRQALIRRLRPDIEVVMYRGNVDTRLRKLDAGEVDGTFLACAGLRRLGLADVITDVLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERAFLGALDGSCRTPIAGLATVEGDRLSFRGMILTPDGRQAHEVTAEGVVSDAAALGTDAANRVRAMAG--------------
>UniRef50_A7GYU4(2-307:311) Porphobilinogen deaminase n=34 Tax=Campylobacterales RepID=HEM3_CAMC5  E=1e-104 s/c=1.25 id=53% cov=96%
---KILKIATRKSALALWQSEHIKARLMAQHAGLQVELVGMKTKGDVILDTPLAKIGGKGLFTKELEDSMLSGQTHIAVHSLKDVPVAFLDGLVLAAICSREDVRDAMISQRYVKFDDLPQSAKVGTTSLRRKMQLLRMRPDLNIISLRGNVQTRLRKLKEGEFDAIILAMAGINRLNLADEVAHIYPFDIaqMTPAMGQGALGVEA-VDDAQILEKIKFLNDERSVIETRVERDFVTLLEGGCQVPIGINARLASEEIEINAIVGLPDGSEVITENLTAKKSEFESVGKELAREFIARGAKELLKR--------
>UniRef50_A8LIJ6(38-334:347) Porphobilinogen deaminase n=11 Tax=Alphaproteobacteria RepID=A8LIJ6_DINSH  E=1e-102 s/c=1.26 id=49% cov=95%
--DSPLKIGTRGSLLALAQAHETRARLSAAFdlPEEAFEIVVIKTTGDRIQDRSLSEIGGKGLFTREIEDAMLDGSIDIAVHSMKDMPVDTPAGLALDTYLPREDVRDAFVTLDGGTLADLPEGAVVGSSSLRRRAQLAHRRPDLQLVEFRGNVQTRMKKLGDGVAHATFLAMAGLNRLGMDEVPRSAIAPEDMLPAVAQGCIGIERRADDPRAAEMLAAIHDGPSGHRLACERAYLSALDGSCQTPIAGLAELDGGSIHLRAEILRPDGSEVLSDSETAPVEDAAKMGREVAERLRAR----------------
>UniRef50_UPI00017922DC(7-370:377) PREDICTED: similar to porphobilinogen deaminase n=1 Tax=Acyrthosiphon pisum RepID=UPI00017922DC  E=1e-102 s/c=1.02 id=43% cov=96%
---KTIRVGSRKSELALIQTKFVISQLKELHPEIEFEIVSMTTMGDRVLDKPLPKIGEKSLFTKDLEVALLSGTVDFIVHSLKDLPTVMEIGTTIGAILKRDDPRDALVLRDDCKeyqLDSLPSKSFIGTSSLRRTAQLKRKFPNLQVSDVRGNLNTRLKKLDSSQstgdntntnYSGIILALAGIQRMGWEKRVSQIIDSDVMLYAVGQGALAVECRLGDDYILEMLEPLHHYETVLQVVAERGFLTRLGGGCSAPVGIRSTVclTKNAMSLDGAVWSLDGAEELQYSSSAELADkkviqshidqyrgedgeppkkcpykqprqfvgvtpgkisyldldtALKLGTELAENLISKGALDIM----------
>UniRef50_C1CYD9(2-311:311) Porphobilinogen deaminase n=3 Tax=Deinococci RepID=HEM3_DEIDV   E=1e-101 s/c=1.19 id=42% cov=96%
---RTVTVGTRGSTLALAQTRWVVARLKEEWPDTDFRIQTISTKGDRNRESleAMAQKGDKGFWVKEIEDALLQKRIDIAVHSLKDLPTEQPEGLEVASIPKRVDARDVLIGKEGmKRLADLPQGARVGTSSVRRKAFLRAYRPDLQVIDLRGNIDTRLAALAGDEYDAIILAAAGLIRTEMRHRIDEFVEPDILLPAPGQGALALETRSgpENDLTIEVAYAIHDHGTDDRITAEREFLAGLGAGCMAPVGAHASIKGGVLTLEGWVGALDGSKVIRATSIGDPAECADIGAELAGDMLGQGAQALID---------
>UniRef50_Q3YSA8(3-293:298) Porphobilinogen deaminase n=17 Tax=Rickettsiales RepID=HEM3_EHRCJ   E=1e-100 s/c=1.26 id=38% cov=93%
-----IRIGTRGSVLALAQTLEVTNLLNRYFPEINIQVVKIKTSGDINNKVPINTIGGKGLFIKEIEEALLIGKVDLAVHSVKDIPAFYCDGLIIPCVLKRSSPYDVFVSSKYQSIKSLPINATVGTSSIRRKVQLNYLRPDLQVIPVRGNIDTRILKSDIGEFDGIVLAEAGLIRINKCNVIKEVLDSKIMLSAVGQGAICVQCRADDYNIINKIKVLNCHKSYVCVIAERSFLKTINGSCDTPLAALAQYVDsDTIYMSCMLSNE--KEMVFSDCYFKECNAEESGIDMGKKLINE----------------
>UniRef50_Q5HBG1(1-296:299) Porphobilinogen deaminase n=2 Tax=Ehrlichia ruminantium RepID=Q5HBG1_EHRRW  E=1e-98 s/c=1.22 id=38% cov=92%
-------VGTRGSILAIAQAMEVKKLLYNYFPDINVQIVHIVTSGDINDKISLSEIGGKGLFLKELEEALLTGTIDLAVHSMKDVPAFYCDSLVIPCILKRSSPYDVFISSKYQSLRSLPDNAVIGTSSIRRKVQLMRLLSSVQVVPIRGNVDTRILKLEAGQYDGIILAKAGLMRINKTHVIKEVLDPQVMLSAVGQGAIGIQCRANDYKMIDMIKILNCKKSYISVAAERSFMKTVNGSCDTPLAALAKyVNSDTLYMSCMLSNEE--KTVFSDCYFNECDAEISGINMGNDLMDQ----------------
>UniRef50_A9FDP9(1-299:300) Porphobilinogen deaminase n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=HEM3_SORC5  E=6e-97 s/c=1.19 id=51% cov=95%
-MPTELTLATRRSALALAQSRAFARSLEAAVPDLSLRELEVVTSGDKTQDRSLQDIGGKGLFIKELEEALLDRRADFAVHSIKDVPAEIAPALCLACIPAREDPRDALVTRSGALLAELPAGARVGTSSLRRAVALREARPDLVIEPVRGNVDTRLRKVFDGVFDAVVLALAGLKRLGLEARATEVLSPEVSLPAIGQGALGIECRTADDSVRDVLGTLADAETTICVSAERAVMAAVEGSCRTPVAAYAVRDGGALWLRALLAEPDGSRLRRAERRlswpGNTREAERLGADLGAELKK-----------------
>UniRef50_C4Z552(4-292:295) Porphobilinogen deaminase n=8 Tax=Bacteria RepID=HEM3_EUBE2   E=1e-96 s/c=1.23 id=43% cov=92%
------RIGTRGSKLALVQSEYVKRRMEEAYPEDTFELVIIKTTGDKVTDKPLAAIGTKGFFVKEIEEALLSGSIDMAVHSMKDMPAECAAGLTFAKAWKREDCRDVLILKTAGSFSELPSGAVIGTGSLRRACQLAMLRPDIQFTAIRGNVDTRINKLMDDSYglDGIVLAAAGLNRLGRSSEITEYLDPEVVIPAPAQGVLAIETAEVNTELLDKINALSDDNSDREAVAERTFLRLTGGGCHAPVGAHCVTKDnGDLRMVVLFGNDDCSRILRIEVTGT--DSEAVGHEAARML-------------------
>UniRef50_C3PNS9(1-254:351) Porphobilinogen deaminase n=15 Tax=Rickettsia RepID=HEM3_RICAE   E=3e-96 s/c=1.39 id=42% cov=81%
-MTNSIRIGTRKSPLALIHTNLVIQQIKQFFPDINCEIVPIITSGDLIQNKPLYDIGGKALFLKEIEQALLDKKIDLAVHSLKDVPGRIPEPLVIAAVLEREDPRDVFVCLKYKSIEELPQNAVIGSSAVRRKAFIQKIRPDLKVTVFRGNVDSRIKKLMTGEVDATILAYTGLKRLEVFNPEYCHLiEYSQMLPCIGQGVIAVEIRKDDNAMLEICNQINHLPTFELIKPERAFLEYLDANCRTPIAAYSQYLD-----------------------------------------------------------
>UniRef50_A2Q9P7(12-335:346) Catalytic activity: 4 porphobilinogen+H(2)O<=>hydroxymethylbilane+4 NH(3) n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2Q9P7_ASPNC  E=2e-95 s/c=1.08 id=40% cov=96%
-----LRLGTRNSKLALVQAEHVSKELTSAHPGVQFPWQTVVVRGDADKSSPFLKFAGpsdaaKNIWTEEMETKLCAGELDLLVHCLKDMPTRLPETCTLGAIVYREDPTDALVIKEglrsqYTDLSQLPPGSVVGTSSTRRKALLRYRYPHLKVEECRGNLGTRLKKLDdpEGPFSAIILATAGMVRINLEDRITKRLPPSEFPYAVGQGALGIEIRKEDAQTKTMVRKIEDLVTRRICLAERSLLRTLQGGCSSPVAVHCTVEQaptasspAQLRLDGTIIHPHGTTLLSERTTaevGTDEDAEALGATVAQQLLKNGGQALLEEI-------
>UniRef50_Q0BX92(11-307:321) Porphobilinogen deaminase n=1 Tax=Hyphomonas neptunium ATCC 15444 RepID=HEM3_HYPNA  E=2e-93 s/c=1.16 id=42% cov=93%
---KRLRLGTRGSPLALAQAHQIADGIRAASAGaYDCEIVAFTTTGDKLTTERLINSGGKGLFTRELDDALSRGELDLAVHSLKDVPSVLPPGQIFAAFPKREDPRDGFLSHGAKSIQDLPEGATLGTASLRREAQALALRPDLKVVTFRGNVATRMRKLEEGLADATFLAMAGLTRLGLSEVAT-PIPLEDMLPAAGQGIIGVVTRDDvDTELLEILGQLSHEPSRVAAIAERAFLEKLDGSCRTPIAAHLFDRGDEWQLIGEVLSPGGTTRWRGDGVCrkDATDAQlvLLGRAVAQEII------------------
>UniRef50_B6W7F3(1-298:318) Putative uncharacterized protein n=1 Tax=Anaerococcus hydrogenalis DSM 7454 RepID=B6W7F3_9FIRM  E=6e-91 s/c=1.13 id=35% cov=95%
----MIKIGSRASKLALIQANMVKDILEKE--GLEAQIVEISTKGDRIRDRKIDQLNSKGVFVREIEEKLLDKTIDIAVHSLKDMPSQIDDRLIFTPPLKGEDPRDCFVGKDvFKKMDDL-NNALVGTGSNRRVCQGKNHFSNIKFKAIRGNVETRIKKVQSENLDGVILAKSGLIRAGLDGEINFDLDPHIFTPSPCQGILGIEIRKEDKKLFEIFKKNSDEKTLFRMETERAFQKELGADCSTPMGIFTEIDHDKITLTGSMAFDKDDRINYERVSGNISERIHLAQKLARTLKKK--------SYKKNNP-
>UniRef50_Q2NEP4(1-288:290) HemC n=4 Tax=Methanobacteriaceae RepID=Q2NEP4_METST   E=4e-88 s/c=1.14 id=32% cov=92%
-------VGTRGSKLATTQTKTVVKALEEIT-GEEIETKIIKTTGDKIKNSQLYNIDAKGIFTKELDTALIDGSIDFAVHSFKDLPSELNDQLTITAIPQREAINEVLISN--YSWDELPENATLGTSSVRREAFCKLHGKKIQTKPIRGNIDTRIRKVEEGEYDATIMALAGINRLGLQEHIKEVFDEQYITPPAGQGALAVMTHK-DSEYNDVISKLNHEDSRIEAMTEKAILETIGVGCQWPIGIVSKVDGNNINIHCKLLSPEGKLLADVNKTTDKNNAINTAKVIGTKLRED----------------
>UniRef50_A0QLI0(1-305:315) Porphobilinogen deaminase n=69 Tax=Actinomycetales RepID=HEM3_MYCA1   E=1e-87 s/c=1.07 id=45% cov=95%
----MIRIGTRGSLLATTQAGGVRDALIAR--GHPAELVTITTAGDR-SSGPIESLG-VGVFTTALREAIEEGRVDAAVHSHKDLPTADDPRFAVAAIPARNDPRDAVVARDGLVLGELPPGSLVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLGDVTETLEPVQMLPAPAQGALAVECRAGDSRLAAVLAELDDADTRASVTAERALLAELEAGCSAPVGAIAEVVESidedgrifeELSLRGCVAALDGSDVIRASGIGTPGRARELGLSVAAELFELGARELMS---------
>UniRef50_C5EV71(1-301:301) Pyruvate ferredoxin/flavodoxin oxidoreductase n=3 Tax=Clostridiales RepID=C5EV71_9FIRM  E=1e-84 s/c=1.05 id=41% cov=93%
-MSNIIRIGTRKSALALIQTHLIADGLKRAWPDIEVELVTKETLGDKILDKPLQEFGGKGVFVSEFEQAMKEGAIDLAVHSAKDLPMELGEGLVIAAVSGRGDPRDVLVTMKGSPKDR--EHIVIGTSSPRRQLEAVEYRgqlwPGaasLTCATLRGNVHTRLRKLEEGLYDGIILAAAGLERLDLLGNPSYdfkYLDPTVFIPAGGQGIMAVEAREG-SDAARLCQAIDSREGRLCLTLERMVLKLLDAGCHEPIGIYSNIMDGKMEVWG-ISRPDRvTRRISLEGAVTEKELEALALQAGRGLM------------------
>UniRef50_A2SQU4(1-291:542) Uroporphyrin-III C-methyltransferase n=11 Tax=Euryarchaeota RepID=A2SQU4_METLZ  E=4e-84 s/c=1.08 id=41% cov=92%
-MSK-IRIGTRGSKLALAQTKKVIGLLAEN--GIDAEYVIIKTTGDKVTDRGLHQIGGFGMFVRELDNAILRGEIDCAVHSMKDIPAERPKGLLTVAVLKRDPPYDFLVMNG--KVEDL---MVIGTSSLRRKAQLLRYFhncPAVRVEMLRGNLDTRLGKLDDGLYDGIMVAEAGLMRLDYK-RNGVRLSPDMFVPAANQGTIAIVSR-DTPELRAAFAPLNDPQSALDCAIERIVMEQVGGGCFTPMGIFCENQ----HLTAEVLSLDGTRAERITAEiGDLEGARVAGI----RLKNVGA-ELIAEAK------
>UniRef50_Q1AUK3(1-297:305) Porphobilinogen deaminase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=HEM3_RUBXD  E=6e-82 s/c=1.03 id=45% cov=94%
-----LVLGTRGSPLALAQAEACAAGLRAA--GFAVELRRIRTTSDRRPDDPLSVIDQRDVFTRQLDEALLAGEVDLAVHSMKDVPTEVPEGIVLAAVAGRADPSDALVSEGGWGVDGLPEGARVATSSLRRRAQLLHRRPDLRVVEIRGNVDTRIRKMRAGAAEAVVLARAGLVRLGLEVPHA-VIPHDVLLPAVGQGALAVAVRRGDPRLEEIRRALNDPAAEREVAAERALLRALEGGCRVPVGARAVAGGRGVLLRGVVVSPDGAALCGGEERGEEPEEVG--RRLAARLLERGAAGIL----------
>UniRef50_Q4PFH9(147-522:770) Putative uncharacterized protein n=1 Tax=Ustilago maydis RepID=Q4PFH9_USTMA  E=5e-81 s/c=0.81 id=44% cov=92%
----TLVLASRNSQLALVQSSHVSAMLEARFGRssplfrsqaeqatgalestssgqsdtsssssprastsssrlqevdgkhsqddvdflckllhgfqttseaplrpHAFPITSMSTAGDQNLRSPLYVIGGEGkaIWTKELEVALEQGAVDAIVHCLKDVPTALPQGLELAAVLEREDPRDALVVKaglPYKVLDELPVGSVIGTSSVRRVAQLRRRYPHLVFSDVRGNINTRLAKLDapNGPYTALILAAAGLVRLNMHARITAFLSSPVLLHSVGQGSLAIEVRTppegadpttnRDARIRELIRSIGDWRATFRAEAERSLLKELEGGCSIPVGVETRFDD------------------HDQVEGQRSEA----IALVDDFVTQGNAGAKAELPNGGMP-
>UniRef50_A2BFN7(19-247:247) Hydroxymethylbilane synthase (Fragment) n=6 Tax=Coelomata RepID=A2BFN7_DANRE  E=1e-77 s/c=1.28 id=49% cov=71%
--SRVIRMGTRKSQLARIQTDSVAGTLKQLYPDVHLEIVAMSTIGDKILDTALSKIGEKSLFTKELENALERNEVDIVVHSLKDLPTSLPPGFTIGAILERENPHDAVVLHPknaGLTLDSLPEKSVIGTSSLRRAAQLKKRFPQLEFENIRGNLNTRLKKLDEkDDYAAIILAAAGLKRMGWESRISQVLGPEDCMYAVGQGALAVEVRAQDKDILEMVSVLHHPDT-----------------------------------------------------------------------------------------
>UniRef50_B4D5X7(2-278:307) Porphobilinogen deaminase n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4D5X7_9BACT  E=3e-77 s/c=1.05 id=41% cov=84%
---KSIILGTRASALAVAQVELTTKALAAAFPAMQIERREFVTRGDKKLDLSLlraNEAGGKGLFTKELEDALLNGSIDVAVHSLKDLPGHNPPGLDITAVLERAPTADVLITKQPQTLLDLPQGVLLGTSSVRRARQLQWRRPDVRVEEWRGNVQTRLRKLaERDDVTGIILAQAGLERLGHDlsagrletehGKFYVTSLAEDLLPAIGQGAIALQSRADRAEVAAVLQKIDHRETHLAIRAERELQRLLAGDCALPVGVRTKLLPGGIAMRAILFGP-----------------------------------------------
>UniRef50_Q83H95(3-321:321) Porphobilinogen deaminase n=2 Tax=Tropheryma whipplei RepID=Q83H95_TROW8  E=6e-73 s/c=0.87 id=38% cov=93%
----PLRIGTRSSLLATAQTAQVQKTMRDVFL-LDTQQVLIQTGSVRRRD---------GSFVAALRTALLEGECDLAVHSLKDIPIAPHEGTLITAVLPREDPCDVLCARKDLTLTTLPSGAKVGTASARRRAQILNFRPDLDVVSLRGNIDKRLIHLDT--LDAIVLSAAGLKRIDREDAITESFDIHDWPTAAGQGSLAIEvCRAqlDDPQNRvAVTYRLDNPMARVTTTAERGVLSLLQADCFSPIAVHAVYtaNDKSLRLHAKVFSRDGKifcESIRfarlvkqltdtnqnhtknsgsDDIGNALEVAMTLAKTVVDELLSKNAREILKQ--------
>UniRef50_Q86ET2(6-209:277) Clone ZZD1450 mRNA sequence n=3 Tax=Schistosoma japonicum RepID=Q86ET2_SCHJA  E=5e-63 s/c=1.19 id=45% cov=59%
-----VRVGSRRSNLALLQTEMAISLLKVQKPHIMFEVVEIATVGDEILDVPLSKIGDKSLFTKELEKSLLVGEVDLVVHSLKDVPSVLPTGLVLGCVFGRSSPEDVVLmapHNRGMKLSDLPVGATVGTSSIRRVATLIRKYPHLKFISIRGNLNTRLAKLDTPsnlqkqcctgnqslSYDALILAKAGVERMGWVDRIDQVLS-----------------------------------------------------------------------------------------------------------------------------
>UniRef50_B5FN93(1-313:313) Porphobilinogen deaminase n=168 Tax=cellular organisms RepID=HEM3_SALDC  E=1e-127 s/c=1.46 id=89% cov=100%
MLDNVLRIATRQSPLALWQAHYVKDALMATHPGLTVELVPMVTRGDVILDTPLAKVGGKGLFVKELEIALLEKRADIAVHSMKDVPVAFPDGLGLVTICEREDPRDAFVSNKYHSLDDLPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLGKLDNGDYDAIILAVAGLKRLGLESRIRTALPPDVSLPAVGQGAVGIECRLDDARTQALLAPLNHSQTALRVTAERAMNTRLEGGCQVPIGSYAEIINGEIWLRALVGAPDGSVMVRGERRGSPEQAEQMGISLAEELLENGARAILTEVYNGETPA
>UniRef50_Q5ZRY6(1-309:309) Porphobilinogen deaminase n=6 Tax=Legionella RepID=HEM3_LEGPH   E=1e-111 s/c=1.31 id=50% cov=99%
MSAKIIRIATRQSPLALWQANHVREMLVKQWPNLSIELLPMITSGDRFLKDKLLSAGGKGLFVKELEEALLDKRADLAVHSTKDMPAQLPDGLLLTAICKRDNPFDALISPQFKSLAALPKNAIIGTSSLRRQSQLLAYNPNLQIKTLRGNIHTRLSKLESGEYQAIILAAAGLERMGLAHHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELVHGLNDPISALCVHTERRVNAKLGGNCHIPFAVYCTITEEKlLLLRAKVLNMDGSQMIDDEQQGKIAEAEVIADRCTESLMTKGAMSLLSTIPS-----
>UniRef50_D2R3S6(1-303:311) Porphobilinogen deaminase n=2 Tax=Planctomycetaceae RepID=D2R3S6_9PLAN  E=1e-103 s/c=1.25 id=48% cov=95%
-----LRLGTRASPLARWQADWVRDQLIAA--GIDVEMILITTEGDQQTSQPLGQIGGQGLFTKEIQRRLLAGDIDLAVHSLKDLPTLPIDGLSLAAVPEREDTADILIGPAGTSLATLPSGAKIGTGSLRRKAQLLHARADLEILDIRGNVDTRLRKLDEGQYHAIILAAAGLKRLKLDDRMTERLEAPLMLPAVGQGALGIESRSDDPTTRKLLAPLSHAPTLQAVIAERSLLAALRAGCLAPVGAHAQVVDGQLTLAAVVLSIDGQSRLFASLTSAPADAAQLGEEVAELLRQQGATELLA---------
>UniRef50_Q43316(72-376:382) Porphobilinogen deaminase, chloroplastic n=61 Tax=cellular organisms RepID=HEM3_ARATH  E=1e-103 s/c=1.24 id=46% cov=95%
----IIRIGTRGSPLALAQAYETREKLKKKHPELvedgAIHIEIIKTTGDKILSQPLADIGGKGLFTKEIDEALINGHIDIAVHSMKDVPTYLPEKTILPCNLPREDVRDAFICLTAATLAELPAGSVVGTASLRRKSQILHKYPALHVeENFRGNVQTRLSKLQGGKVQATLLALAGLKRLSMTENVASILSLDEMLPAVAQGAIGIACRTDDDKMATYLASLNHEETRLAISCERAFLETLDGSCRTPIAGYASKDeEGNCIFRGLVASPDGTKVLETSRKGPyvYEDMVKMGKDAGQELLSRAG--------------
>UniRef50_C8WXM9(2-300:305) Porphobilinogen deaminase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WXM9_ALIAD  E=1e-101 s/c=1.24 id=50% cov=96%
---RTLRVATRRSALALTQTNHVVDLLKQVAHGVEFELVPIRTRGDEIVDRALSEVGGKGLFVADIEDALATGQADLAVHSLKDVPFELRDGLTIGAVPPREDPRDALISRTGQGLFDLPPGARVGTSSLRRQAALRRLRPDLCVETLRGNVDTRLRRLEEGQFDAIVLAASGLHRLGLAERITEYLPVDRFVPAVGQGALAIECRAEDDEVMRHLAAIADPDATRAVEAERAFLSRLEGSCQVPIGAYAEPVGHELRLIAFVADPSGIHHLQLERTG--DEARALGVAMAEEMLRQGAEDWLK---------
>UniRef50_B0K2L4(1-296:299) Porphobilinogen deaminase n=7 Tax=Bacteria RepID=B0K2L4_THEPX   E=1e-100 s/c=1.24 id=37% cov=94%
-MKKVIKVGTRSSELALKQTAMVINEIKKFRQDFEFEIVKITTQGDALIDKPVSEIGGKGVFVKEIESALLKGEIDMAVHSMKDMPYEIPKGLKLMAVLKREDPKDVFVSGDGTQFMDLKEGAKIGTSSLRRQVQLKALKPDIQIVPIRGNVRTRLKKMEELNLDGIVLSAAGLHRLGLENIITEYFPPDVVVPAPCQGILAVEIAESfDNIFQEFYPYIVDRKTFFEASVERELLKAFGVNCRQPFGAYAQYRkeEDEEKINIKVAYQKENKLLKSEVTGLIEETDKMIEKLIEEF-------------------
>UniRef50_C6XGK7(1-294:307) Porphobilinogen deaminase n=1 Tax=Candidatus Liberibacter asiaticus str. psy62 RepID=C6XGK7_LIBAP  E=2e-98 s/c=1.23 id=39% cov=94%
MEKKPFRIGTRCSPLALAHAFETRSSLMDVHkiPPHNIVIIPLSTKGDRITNRTLTEIGGKGLFTEEIEKKLISGEIDCAVHSAKDMPTKLLKGLQISAYLPREDIRDVFISHTAQSLKDLALHSVIGTSSLRRKALLLRWRSDISVIDFRGKIETRLNKLNNNKAHAILLAYAGIKRLKKEKVIKEILNIEDFPPSPGQGAICIETHVNNPKAQELVKVINHEDTWDSVNCERAFLAELDGSCKSAIAGFAYCKGSTLYFYGIVLASDGKIFHEVSRNGNRCDAINIGRDAAQ---------------------
>UniRef50_A6GVP0(1-305:308) Hydroxymethylbilane synthase n=18 Tax=Bacteroidetes RepID=A6GVP0_FLAPJ  E=3e-97 s/c=1.17 id=37% cov=97%
MAKKTIKIGTRDSELALWQAHHVEKMLNDL--GHKTKIIAVKSQGDIILDKPLYELGITGIFTKTLDIAMVNGDIDIAVHSMKDVPTALPQGIVQAAVLERANEKDILVYNN--NLDFLNTQATIATGSLRRQAQWLHKYPNHKVVDLRGNVNTRMQKLQDNNWNGAVFAAAGLERINIKPENYINL--DWMIPAPAQGAMMVVAMGNDTYCLDALAELNHIETEITTYIERQFLRTLEGGCTAPIGAYARFneKDETIHFQGVLFSLDGSQKIEIKKIVEIQEWKQLGYHAGQEIFENGGVQLMKTIKEK----
>UniRef50_B3U3W9(76-377:395) Hydroxymethylbilane synthetase n=1 Tax=Oxyrrhis marina RepID=B3U3W9_OXYMA  E=3e-96 s/c=1.17 id=43% cov=96%
-----LRIGTRGSPLALAQARDVESRAREQlQQGGEIDICVISTEGDRILDRALADVGGKGLFTKELDRALLSGEVDCCVHSMKDVPTTVAPGTEIVAYLPREDTRDVFLSAKYATLADLPDGAVVGTASLRRQAQILAQ-KNVVVTNFRGNVQTRLRKLAAGTVDCTFLAYAGLKRLGMLAEATQVLEWSDMLPAIAQGAVGIQIRSNDAALRGTLSQLDHEPTRLAVETERAFLRALDGSCRTPIAGQAWIgPDSRLAFRGQVLSADGKQRFERVGDCLPCDGPELGKTLGDDLRREAGEEFFAEL-------
>UniRef50_A8MGE4(3-289:296) Porphobilinogen deaminase n=30 Tax=cellular organisms RepID=HEM3_ALKOO  E=1e-92 s/c=1.19 id=40% cov=91%
-----IRVGSRESKLAVKQSEIVIEAIRKYDPNIEIELVTMKTTGDIKLDQTLDKIGGKGLFIKELDQALYDDRVDITVHSFKDMPMAIDEYLPIVAVSKREDPRDVLVLPK--TVKEPDFSKPIGCSSFRRKIQLQEIYPHCSVEPIRGNVLTRLEKLDRGEFSAITLALAGLKRLGLEERISRIFEVTEILPAACQGVIVVQARKG--FDVSFLSDFHDKEAWDISMAERSFVRTLNGGCSSPVAAYGEIKDNYLTLTGLYVDSSNS-VHKKTITGARKQGEEMGFNLALQMK------------------
>UniRef50_C8WIZ2(4-321:327) Porphobilinogen deaminase n=2 Tax=Coriobacteriaceae RepID=C8WIZ2_EGGLE  E=8e-92 s/c=1.07 id=45% cov=97%
-----MRIGTRGSKLALWQAHHVADLLRAASPGMDVSVEVVKTKGDRILGVALSKIGDKGLFTKELEQALFDGRVDVCVHSMKDVPTALPEGLALAGCLIRADARDVLVAASGTTFAGLPAGSRVGTGALRRLSQLRAVRDDLDYVEVRGNLDTRIAKVRDGALDAVVLAAAGIERMGWSAEVAEAFSVDTVVPAVGQGAIGLEVRADDERTARACAQVRCAATDACVAAERHVMRALDGGCQVPIGAYARYEEGLLVLDAFVGSLDGSHVLRSRlsaasqppndtdaVEAAVREARALAQRAVEEFEAQGARAVLDAVRA-----
>UniRef50_C6XKH7(17-314:323) Porphobilinogen deaminase n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XKH7_HIRBI  E=2e-91 s/c=1.13 id=38% cov=93%
--TQIVKIGARGSPLAVQQAEDFAARFKEIVGNtVEIEIHTFTTSGDQLLDKRLQDAGGKGLFTRELDIAQLSGRIDIVVHSLKDVPTVLPDGLQMGCYLPREDPRDALFGKVG-NIKDLPHGATLGTASLRRSAQALALRPDLKIVMFRGNVQTRLRKLEEGQADATLLAAAGLNRLGMTDKAAGFMPKEEMLPACGQGIVCTTlTNNAEDWIFKACLQIDVLESRIAAIAERAFLKRLDGSCRTPIAGHLSFNETGVDMRGEVLADDGSKRWFSQMSLdtipDENQAASLGFELGEKV-------------------
>UniRef50_B2IAW6(19-321:337) Porphobilinogen deaminase n=4 Tax=Alphaproteobacteria RepID=B2IAW6_BEII9  E=5e-90 s/c=1.10 id=46% cov=96%
-----LRLGTRGSPLALAQAHELADRLARAHgfAKEAVAITIIRTSGDMIQDRPLSLAGGKGLFTKELDQALIEGMVDLAVHSAKDLPTILPEDLIIAGYLPREDVRDVWISPKAGHPRDLPPGSVVGTASLRRGALLKRLRPDLEVRLLRGNVETRLAKLAAGEVDATLLALAGLRRLGLADKATQVLAIEDFLPAAGQGAIGITTRRDDAATLALLAPILDPATHVALAAERGFLTVLDGSCKTPIGAHATVEHDQVTLRGIVLRPDGSEWFEACESGPLESGS---LEAARELGETAARAILARLPEG----
>UniRef50_Q46CH0(1-299:316) Probable porphobilinogen deaminase n=7 Tax=Euryarchaeota RepID=HEM3_METBF  E=5e-90 s/c=1.11 id=38% cov=94%
-------IGTRGSQLALAQAETVARLLKAK--GVETSLKIIKTSGDRFTDRPLHAVsSGVGAFVRELDEVMLEGKIDIAVHSMKDMPTIRPPTLPTVAVLKRDTPFDLLLTYDGTPLDELSEQSIIGTSSLRRAAQIKRYRPDLVTQDLRGNIDTRLRKLKEGKYDGILLAKAGLERMGWELE-GEILSPDFFCPSPNQGTIAVVTRAE-TEAEAAVSRLDHTDSRIATEIERILISELGGGCTTPIGSYAEIMPDRkkLHVRAEVLSLDGEETVGINEFIPMAGGIEKARELGSSLVHMGGKKLADE--------
>UniRef50_C1TM53(160-442:454) Porphobilinogen deaminase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TM53_9BACT  E=2e-89 s/c=1.17 id=44% cov=90%
---------SRKSALARAQTMEAARALAKK--GLPVEIKTMSTCGDEKQDCHLSAFGGNGAFVKCLEEAIMEGKGDGAIHSLKDVPSVLPDGLELVAVLPRASTSDVIVSNHKGGLEGLPAGAVVGTSSLRRKAQLAITRPDLDYTLIRGNVNTRLAKLQSGDADAIVLAKAGLDRLGISPEGATTLP---FLPAPCQGIIAVEARSG-SRLAEEFRAINHRPTWLMALAERELLESLQVGCHVPFAALSEWVGGELRLRAQTLSYDGRHIdFEGSlAVRSDDDARDLGRDVALSIKA-----------------
>UniRef50_A8AAB4(3-292:304) Probable porphobilinogen deaminase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=HEM3_IGNH4  E=2e-88 s/c=1.13 id=39% cov=92%
-----IKIAARGSKLSLKQVSMFTSYLLKFFPDLEYEVITVKTTGDKANApfEELAKRGLTGLFEKEVNKAVLEGKADVAVHSLKDLPTELDPRLEIAAFLPRDPPYDVLISRAGNyDIFDLPKGSVVGTSSARRKALIKNLRPDLVVKDLRGNVDTRLEKLRRGEYDAIVLAEAGVSRLGL-NVDYVRLDWRLFPPSPGQGIIVAVTRKG-SEISDLLKSISDVKSEKLATAERTVLKEFGGGCFVALGAIAFEEGSLIRLRATVLSPSGRERVDVELIG--KGPEEVGMRAAERLKA-----------------
>UniRef50_Q9F7M2(3-303:303) Predicted porphobilinogen deaminase n=2 Tax=Bacteria RepID=Q9F7M2_PRB01  E=4e-88 s/c=1.09 id=37% cov=96%
-----IRIATRQSELAMYQAKFVADELLAKINNIKVELVPMTSEGDQ-TDKPLHEIGGKGLFISTLESSLEADEADIAVHSLKDVPAKLDPKFKIISVFSRESPEDLLLSKDGKSFSEFARNSTIGTSGPRRKAQINNLRPDIKTIPVRGNIATRIKKLNDGLFDGLVVAKAAIKRLGLKQNSYE-FSIEEMLPSASQGYIAIECLSDKKDIIELLENIGDPKELILASAERSFVAAMEGTCLSPIAILCEDKNGQIKISGKILSYEGNEKIYKEKISSFQDIAIDIMLFADEFILEGAKSLI--LKNDN---
>UniRef50_O26960(4-285:289) Probable porphobilinogen deaminase n=1 Tax=Methanothermobacter thermautotrophicus str. Delta H RepID=HEM3_METTH  E=5e-87 s/c=1.15 id=36% cov=90%
--------GTRGSRLALVQTNHVIEMLSEVCKEKIEKKIIKT-KGDRIRDSQLYSMDSRGLFTRELDMAVLNEEVDLAVHSLKDVPSDLDPDLAIAAVPPRESPAEVLVSR--LDWEDLPQGSKLGTSSLRREAFCNHHQKNFKMEPLRGNIDTRIRKVMDGEVHATIMAEAGLKRLGLEEHIKRRFPVEYFTPAAGQGALAVITRA-DSELISSIGRITHHPSLQEVTAEKTLLRELGAGCQCPLGVIGRATGNQLTLYAVLLTREGEMLRKVTVRGPLAEAEDIGKKAAKEM-------------------
>UniRef50_Q1EPC8(54-322:328) Porphobilinogen deaminase, chloroplast (Hydroxymethylbilane synthase) (Pre-uroporphyrinogen synthase), putative n=1 Tax=Musa acuminata RepID=Q1EPC8_MUSAC  E=3e-86 s/c=1.19 id=49% cov=84%
----------RDSDLALAQARETRDKLKAAHSELaeegAVEIIIIKTTGDMILDKPLADIGGKGLFTKEIDDALLQGRIDIAVHSMKDVPTYLPEGTILPC--------------------NLPA-------SLRRQSQILCRYPSLKVVNLRGNVQTRLTKLKNGDVHATLLALAGLKRLNMVENVTSILSMEEMLPAVAQGAIGIACRSNDNKMMEYLSSLNHEDTRSAVACEREFLTVLDGNCRTPIAAYAhRDKDGSCSFRGLLASPDGSKVYETTRIGPYsfDDMVEMGKDAGHELKAKAG--------------
>UniRef50_B2ULP1(3-315:325) Porphobilinogen deaminase n=1 Tax=Akkermansia muciniphila ATCC BAA-835 RepID=B2ULP1_AKKM8  E=1e-85 s/c=1.02 id=41% cov=95%
--KNTLIIGTRGSALALAQADMVRAALSLRYPELDVRCEIIHTIGDRRTDVPLADVArvsgmvDKGIFIKELETALRDGRIDVAVHSLKDVPSELAAGFTLAAVLPRAAVEDVLITKEPDWNGS----GTLATGSVRRRLMARtYWGSGLRFENLRGNVPTRLGKLvEHPGWDAVILARAGLERLGLyapetlvegRKLYMRPLPVEVFIPAVGQGIVGMECRSSDRETAEMLEGINDPESFACALAERAFLVRLGANCSTPVGVYAHPDGEELVLRAAYYVPGREEPFAVVIRGDRKAPEALGLRAFEELGLSGWRK------------
>UniRef50_C6V4N6(3-286:286) Porphobilinogen deaminase n=2 Tax=Neorickettsia RepID=C6V4N6_NEORI   E=2e-81 s/c=1.07 id=40% cov=91%
-----LKVGARCSTLALAQARLVERALAPYCERID--LVGVRTSGDILSDIPLTEVGGKALFLKELEEKLLTGEIDIAVHSMKDVPAFYHDDLEVVPVLKRAIPNDVFVSFRYPNMLSLPSGAVIGTCAPRRVVQLNQRF---RVIPLRGNIATRVEKAKN--LDGIILAFCGLERLGLCKMISEVIHEDVMLPGVAQGALCVEFRKKDHFLRELILNISDRETIICTTAERAFLEEINGDCKTALGALAVVKNNTLYFTGMLGKDNRPCYFRTS--GSCLNAKQIGRSAALALLRM----------------
>UniRef50_D1JID7(1-288:290) Porphobilinogen deaminase n=1 Tax=uncultured archaeon RepID=D1JID7_9ARCH  E=2e-81 s/c=1.06 id=35% cov=90%
-------VGTRGSNLALVQTKKVCERLSEL--GVECEIKTVQSLGDVMTDRGLYEMPTIGVFVKKLDMMLLDAKIDIAVHSMKDMPSEREEELDTSAVLPRDSPYDALVSR--YRLDDMPEGAVIGTSSVRRRYQFLNyvgeRGVKVTIKDIRGNVDTRIAKFRRGEYDSVILAEAGFERLKLDIEY-ERLDRDPFVPSPRQGIIAVVARRGSKE-SEILKQIDDSETRIEAEVEEEVLKVIGGGCSLPVGVHATAKGGSVELAVYVAASDVRYKLEKVVLGKDYYMEET-RELAQKFKS-----------------
>UniRef50_Q97B26(3-262:297) Probable porphobilinogen deaminase n=2 Tax=Thermoplasma RepID=HEM3_THEVO  E=1e-76 s/c=1.11 id=33% cov=83%
-----IKIGTRPSNLAVAQANMVASSLEAI--GIDTEIVKHRSAGDIDTKNPIYSIGKTGVFVQDLNNMILRGEIDVAVHSAKDIPSEIENRLTIAATLKRGSFNDALVSKYD--LRSLPISAKVGTSSIRRIFQLKYARQDLKFENIRGNIETRIAKMSELGLDAIVMAEAAIQRLGLNVEYSK-LDENKFVPAPNQGIIAVVSKKEGT-VRKILEEINDENTFEEMQIERSVVQQLKLGCSTPVGILSRPSGKGHKIIAQFFSMQGDDV------------------------------------------
>UniRef50_B0WMK9(167-409:474) Porphobilinogen deaminase n=1 Tax=Culex quinquefasciatus RepID=B0WMK9_CULQU  E=3e-75 s/c=1.17 id=45% cov=68%
------------SKLALIQTKYVISCLQKLNPDVVYEIRkyfqhvhlcwhvpsyllafflspdTMTTVGDRVLNKSLPKIGEKSLFTKDLEDALRTGGVDFVVHSLKDLPTALPLGMAIGAVLERDDPRDALVlneAHRGRTLSTLPKGSVVGTSSLRRSAQLARKYENVVVCDIRGNLNTRLAKLDADgsKFAGIILAQAGLVRMGWNARVSQVIEPGEILYAVGQGALAVECRSNDEYILDMLSKLCHLET-----------------------------------------------------------------------------------------
>UniRef50_C1XV35(1-266:304) Porphobilinogen deaminase n=2 Tax=Meiothermus RepID=C1XV35_9DEIN   E=3e-75 s/c=1.07 id=45% cov=79%
-----VRIATRGSRLARWQAEWVAAQLQDQ--GIASTLVIVETQGDRER-VAFSQMQGQGFFTKAVQDAVREGRADLAVHSLKDLPSAPTPGLVLAAIPIREDPREALLVLPSAWDAQapalpLAPGARVGSSAVRRQAQLAQLRPDLKLLELRGNVPTRVEKLQSGGYEAILLAWAGLKRLGLDlgGLAVRLLEPREFVPAPGQGALALECREEDTQLRGVLQGLDDPTARLTVGIERGLMARLQGGCQLALGASAQRVQG----------------------------------------------------------
>UniRef50_UPI000038E213(2-280:285) porphobilinogen deaminase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E213  E=4e-72 s/c=0.98 id=36% cov=80%
----PVTIGTRNSKLALIQANSVKDALESR--GYEVNIKSYTSAGDSNKNIPLYRMSSTGVFVDELNERVLKGEIDLAVHSAKDIPSNIQKGLEITAVTGRDDFRDVLISR--TPLEEMTAGSVIGTSSMRRIRQAMTVNPEITVSDIRGNIDTRISKYTEKKYTGIIIAMAAYKRMKLDIE-HFILSEEQFLPAPNQGIIAIVGKSNSPASI-ISGEINDRETYRDMKNERFIATSLNLGCSMPVGILSK--DGKIKTR-----------------------------------------------------
>UniRef50_A5K0J5(2-338:341) Porphobilinogen deaminase, putative n=1 Tax=Plasmodium vivax RepID=A5K0J5_PLAVI  E=1e-68 s/c=0.78 id=35% cov=81%
--------------------------------------------GDHILDKKVGLFGGKGIFTKELDEQLIKKNVHICVHSLKDVPMELPEHVQLSCFLKRDTINDAFLSVKYATLEDMNKRKmankveeesdqekgtiqqmtnqglkrdncegdkctnfipTIGTSSLRRSSQIKYTYKNVAVKNVRGNINTRIAKLCNGQYDAIIIAKCGLERLLTKKVVRNIIrgkgkvPPEKFLlnhndmetnlrllriqqinrrtiyPALCQGIIAVTSHKNDVDTSNILKNINDEKAQIMANVERSFLYQIEGNCMMPIGGYAQIVGGEIVFNAVINDTHGREKYHVREVGTVQNCNNIAAMAATKMKEK----------------
>UniRef50_C5LJF7(7-288:556) Porphobilinogen deaminase, putative n=5 Tax=Perkinsus marinus ATCC 50983 RepID=C5LJF7_9ALVE  E=1e-51 s/c=0.73 id=31% cov=79%
--PSVLHIGSRRSDLARLQTLMIADLLQDEM-GVKVECHYREAPGDTNLKDPLWKMPETGVFTSFLRDGLMNGAFDLVVHSWKDLPLAEESGTTVVATLPRADPRDLLLIRRDAIEEMTSEGGKliVLSSSPRRQFnltpFLESVVPGvtsVQFRDVRGNIQTRMKKLMDPTIhdeslgcrpHGLVVAKAAVDRFIRSTReefkesrqlvqgyisecRCMVLPLSANPTAAAQGALGIEVSTapEKEHVRKIVRSLNDRSTFDAASKEKELLNSYGGGCHQKIGC-----------------------------------------------------------------
>UniRef50_D0RNS6(1-265:492) Putative porphobilinogen deaminase (Pbg)(Hydroxymethylbilane synthase) (Hmbs) (Pre-uroporphyrinogen synthase) n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RNS6_9RICK  E=1e-48 s/c=0.74 id=31% cov=77%
-MSLSLIIGSRASFLAKIQTFIVKQELKKKIKNIKITTKYHSTKGDKNQGHMPWKNLGYGIFTTSLTNELINKNFNCVVHSYKDLP-VLKSKTD-YYVITRDDPRDV---LLVKKKCLNKKKFIVGTSSPRRKSSVKDLKdltgiKDIKTKTIRGNVTTRLLKVISkNQYDAVFMAKAAIDRifkygnkvdkvetkkfLNLFKKFKpFILPLSIFPTAASQGAIAVEYLKNDKKTKSTLNKINCKKTLSICNQERSLLKKYGGGCGLDIG------------------------------------------------------------------
>UniRef50_UPI0001B4213A(6-127:128) porphobilinogen deaminase n=1 Tax=Listeria monocytogenes LO28 RepID=UPI0001B4213A  E=5e-33 s/c=1.18 id=42% cov=39%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDIPPEVCLPAVGQGALAIECRESDQQIRDMLTSIHHEETGICVEAERVFLKKLNGGCEIPIAGFATRANEFVQFKGLVGNADGSIILESEQVGA--NPSEIGNKVAEDLLSEGADTIIKELRN-----
>UniRef50_C4Z1K5(42-254:287) Putative uncharacterized protein n=1 Tax=Eubacterium eligens ATCC 27750 RepID=C4Z1K5_EUBE2  E=6e-20 s/c=0.47 id=24% cov=45%
---------------------------------------------------------------------------------------QLDDGIVISGVIKRRDPRYVMIRRRGT--KDVVENAVVVTDSDENAAVICEMYDNVECV-VENNIKDCMSKLDSEECDAVFafyddirIA-----RLynGLKYKYT-LMDFSDCVPPHGQGIYCILTNGKRSVIKHMFD-VSHRTTAMSFDIEEDIIRRL---------------------------------------------------------------------------
>UniRef50_Q3ACT3(1-310:311) Porphobilinogen deaminase n=2 Tax=Bacteria RepID=HEM3_CARHZ   E=1e-121 s/c=1.41 id=47% cov=99%
-MKKEVIVGSRDSALALWQTNWVVERLSKIHPEINFKIVTMKTKGDKILDVALAKIGDKGLFTKELEHALLNKTIDMAVHSMKDLPTVLPEGLKIGAFCEREYPGDVFISPKGFKFLELPQGARIGTSSLRRIAQILAVRPDLQAIPLRGNLPTRFRKMEEMDLDGIILAYAGVKRLGYEDKITEMLSFDLCLPAVGQGSIGVEIRADDTFIEELLKPIDHFATNRAIRAERAFLKRLEGGCQIPIGAYSEVKENRLHLKGVVASLDGKLVIKGEKEGSIEEPEKVGISLAEELLTKGAQKILEEIRRDAN--
>UniRef50_C0Q9U2(19-325:325) HemC n=2 Tax=Bacteria RepID=C0Q9U2_DESAH   E=1e-119 s/c=1.40 id=47% cov=98%
-MKKTIKIGTRGSKLALWQANHVKDRIEDQFPETEVEIMTIKTTGDMIVDRPLSMVGGKGLFVKEIEKALLESTIDMAVHSMKDMPGELPPGLVIGAVPARENPFDVLISNNNLSLADLPKGARIGTSSLRRASQIKHARPDIETASIRGNLDTRLKKLAAGEFDATLLAAAGLIRLGMKTVITQYFDETIMIPAVGQGALCIESRQEDLDIAPVLAFLNHGETHTVVSGERAFLRRLDGSCHIPVACFGRLEDHRVILTGLVASEDGRTILKETVAGTPEDPQKAGIALAETLLSKGADKILENLNS-----
>UniRef50_Q0I178(3-319:321) Porphobilinogen deaminase n=45 Tax=Bacteria RepID=HEM3_HAES1   E=1e-118 s/c=1.34 id=65% cov=98%
-INKTLKIATRQSPLALWQANYVKNRLQQRYSHLSVELVPIITKGDVILDTPLAKIGGKGLFVKELENALLNGEADIAVHSMKDVPMQFPKGLELSVICPREDPRDAFVSNKYRTLDELPQGAIVGTSSLRRQCQLKNWRADLDIRSLRGNVGTRLNKLDQGDYDAIILASAGLIRLGLTERIRSFIEIDTILPACGQGAVGIECRVDDRDVQSLLMPLADQTTTYCVLAERAMNFHLQGGCQVPIGAYAILENNQLYLRGLVGDVHGSQILSAEgqfelsldfesSQSAVQKAEELGVSIAEQLLQQGADKILQAVY------
>UniRef50_Q8DIE4(5-318:320) Porphobilinogen deaminase n=11 Tax=cellular organisms RepID=HEM3_THEEB  E=1e-117 s/c=1.34 id=49% cov=99%
--SRPVRIGSRKSQLALVQTEWVQAQLQTHHRDRAFEVVTMTTQGDNILDVALAKIGDKGLFTKELELSMLRGETDLAVHSLKDLPTQLPDGLVLAAITEREDPADALVLgakWTGHTIDTLPEGTVIGTSSLRRLAQLRHYYPHLTFKDVRGNLNTRLAKLDAGEYDALILAVAGLRRLGFGDRISQVLPATVSLYAVGQGALGIECRAEDADILALVKTLEHPETTARCLAERAFLRQLEGGCQVPIGVHTVIENGQLTLTGLVASLDGQRLVKDSLTGDVATAEELGTRLALKLREQGASEILEEIFATVRP-
>UniRef50_C9KL85(1-307:315) Hydroxymethylbilane synthase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KL85_9FIRM  E=1e-115 s/c=1.35 id=53% cov=98%
MKNDTIVIGTRSSKLALWQADYVADCLRKRYPELRVEKKLMTTKGDKILDAPLAKIGGKGLFTKELEQDMLAGGIDIAVHSLKDMPTEVPEGLVISAITERFDPGDAVVSPKYRTLENLPQGAKVGTSSLRRKAQLLHARPDLQISDLRGNVNTRLEKLEREHFDAIILAVAGLKRLGFADRITEVLPREMVLPAVGQGALAIETRENDREVRNLIAFLNDEATVACARAERAFLARVEGGCQVPVGVYAVPEaEGRLHVEAVIASLDGARLYRDAAVGSAAEAESLGTALADKLLAMGGIAILHEI-------
>UniRef50_A6TJD5(2-308:316) Porphobilinogen deaminase n=2 Tax=Firmicutes RepID=HEM3_ALKMQ   E=1e-114 s/c=1.35 id=45% cov=98%
---RTIKIGSRASQLALVQAEIIINMLKEKFPQYTYEIIKITTLGDRILDKTLDKIGGKGLFVKEIQKALAEEKIDLAIHSMKDMPGETPEELVLGAITKREDPRDVLITRENKSLEELPKGAVIGSSSLRRQAQVMALRGDIKVVPIRGNVGTRLGKIETESLDGVILAAAGLNRLGLKEKISSYLEIEDFTPAVGQGALGCEARRKDIEMLEMLLAINHEETYRCVMAERAFLKLLEGGCHVPIGAYGQQQGQELHMTGMVASSDGRRVIKEQVMGDIADFQALGIQLGETLIEKGAKEILETVNTDN---
>UniRef50_B5EBG8(1-309:318) Porphobilinogen deaminase n=166 Tax=Bacteria RepID=HEM3_GEOBB   E=1e-114 s/c=1.34 id=51% cov=98%
MALKELRIGTRASQLALWQANWVKSELEKRYPDMTVTLTKIKTIGDKILDVPLAQVGGKGLFVKEIEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVISN-GVKFADLPQGARIGTSALRRQAQLLKVRPDLEMVIIRGNVQTRMDKLKTEGLDAVILAAAGLNRLGFADQITEMLPTDLSLPAIGQGALGIECNLSNQDVKDAISFFNSPDTSRAVRAERALLWRCEGGCQVPIAAFGEVTGDQLKLTGFIASVDGKVSVKGVVTGPADDCEKLGVKLAEQLLSEGGHAILAEVY------
>UniRef50_Q31PM2(7-318:320) Porphobilinogen deaminase n=8 Tax=cellular organisms RepID=HEM3_SYNE7  E=1e-112 s/c=1.31 id=49% cov=99%
---RPIRIGSRKSQLALVQTHWVQGELQRLYPDRQFDVQTMSTQGDIILDVALAKIGDKGLFTKELEVAMLAGEVDFAVHSLKDLPTRLPEGLILGCVTEREDPADALVVHDrfkDHQLETLPEGTVIGTSSLRRLAQLRHHYPHLQFKDVRGNLNTRLAKLDAGEYDALILAAAGLQRLSMADRIHQLIPAAVSLHAVGQGALGIECRAEDPEILELLKALEHEPTSQRCLAERAFLRELEGGCQVPIGVNTAIADGTLTLTGMVASLDGQRLLRDQVSGPTSDPEALGLALAAQLKAQGAKEILDEIFATVRP-
>UniRef50_B3QWI1(1-314:314) Porphobilinogen deaminase n=12 Tax=Chlorobiaceae RepID=HEM3_CHLT3   E=1e-107 s/c=1.24 id=46% cov=99%
-MKKALIIGTRSSPLALWQAEFIKAELSKHYPSLDISLRHIKTTGDKILDAPLAKIGDKGLFTREIEHVMLRNEIDLAVHSLKDLPTETPEGLVITAITEREDNRDVLISKGKYTLKTLPQGAIVATSSLRRRSQLLHLRPDLEVIDMRGNLNTRFKRFEEGDAEAMLLAFAGVHRLEFSEHIAEIISFDDILPAVGQGALGIETRIDDEETRELLKVLNHAETELCTKCERSLLRTLEGGCQIPIGAHARIENGTFHFATYVGSIDGKRAIKKSLSrenvTTVEEAEQIGIEVADAARAAGANEILCEIRTDNA--
>UniRef50_A3ETN3(1-314:314) Porphobilinogen deaminase n=2 Tax=Leptospirillum sp. Group II RepID=A3ETN3_9BACT  E=1e-106 s/c=1.23 id=49% cov=99%
MLPTPLKIGSRGSELALWQARHVAS-LIESVSGVLPEIVVIKTTGDIILDRQLSEVGGKGLFVKEIEEALLRKEIDLAVHSMKDVPAFLPPGLTLAATLTREDPRDVFLSPHYPDIKSLPQKARVGTSSLRRLAQIREIRNDLEFIPLRGNVGTRIRKMEEGVVDAIILAGAGLLRLGHANRVREWISPRVLLPAIGQGALGLEIRTDDETTGTLVRSLSDESTHLSVAAERGVLQSLNGGCQVPIAAYAVWEKNrTLSLEGRVLDISGTRRIHARETrdiVTIDDAYQMGIDLGNRLLSDGAEEILNSILKKSS--
>UniRef50_P28789(1-322:327) Porphobilinogen deaminase n=18 Tax=Saccharomycetales RepID=HEM3_YEAST  E=1e-103 s/c=1.17 id=40% cov=98%
MGPETLHIGGRKSKLAVIQSNHVLKLIEEKYPDYDCKVFTLQTLGDQIQFKPLYSFGGKALWTKELEDHLYhddpSKKLDLIVHSLKDMPTLLPEGFELGGITKRVDPTDCLVMPfysAYKSLDDLPDGGIVGTSSVRRSAQLKRKYPHLKFESVRGNIQTRLQKLDDPKspYQCIILASAGLMRMGLENRITQRFHSDTMYHAVGQGALGIEIRKGDTKMMKILDEICDLNATICCLSERALMRTLEGGCSVPIGVESKYNEETkkLLLKAIVVDVEGTEAVEDEiemlIENVKEDSMACGKILAERMIADGAKKILDEIN------
>UniRef50_Q8RFP5(1-295:298) Porphobilinogen deaminase n=16 Tax=Fusobacteriaceae RepID=HEM3_FUSNN  E=1e-102 s/c=1.27 id=40% cov=94%
-MKKNIIIGSRGSILALAQANLVKDRLQGNYPNLSFEIKEIVTSGDKDLKSNWenSDISLKSFFTKEIEQELLDGEIDIAVHSMKDMPAVSAKSLICGAIPDREDPRDVLVSKNGL-LVTLPQGAKVGTSSLRRAMNLKTVRPDFEIKHLRGNIHTRLKKLETEDYDAIVLAAAGLKRTGLADKITEYLNGEVFPPAPAQGVLYIQCRENDEEIKEILKSIHNEAIAKIVEIEREFSKIFDGGCHTPMGCYSQVNGDKIKFTAVY--LDEGKQIRAVVEDDLAKGKEIAYMAAEEIKNK----------------
>UniRef50_UPI0001926E0E(28-369:418) PREDICTED: similar to hydroxymethylbilane synthase, partial n=1 Tax=Hydra magnipapillata RepID=UPI0001926E0E  E=1e-101 s/c=1.08 id=40% cov=98%
--KTSVVVGSRKSQLAVIQTKSIVAALCQKEKDVECIIETMDTLGDKILHIALPKIGEKSLFTKDLELALSEKRVDFLVHSLKDLPTTLPQGMAISTIYKRDDPRDCIIFhpkHNGKKLADLPENSIIGTSSLRRVAQLKRKYNKLTFQSVRGNLNTRLQKLEEESlYDAIVLAKAGVDRMGWTEKIGQILSEDECLYAIGQGAITVEVRNDDKYTISILAQLTDMETLLACVAERCFMRTLNGGCSTPIACHSQFSGNNYSLRGIVLNADGSRFLDSTVSTTLQvniltdqneppsytvsksgvvinslyinefiKAEKCGEELAYCLKKLGADDVLKEVRSK----
>UniRef50_UPI0000583C22(6-317:324) PREDICTED: hypothetical protein n=1 Tax=Strongylocentrotus purpuratus RepID=UPI0000583C22  E=1e-100 s/c=1.18 id=41% cov=97%
---EIVRVGSRKSELAMIQTNHVVEMLQKVHPETEFKIVTMETIGDHIQDKPLASIGESNLFTKELEKALALDEVDMLVHSLKDMPSRLPSNMAIGAICEREDPHDALVLHKkltGISIETMKEGSVLGTSSVRRVAQLKRKFPHLVFKDVRGNLNTRLRKLDEGQvYDGLVLAVAGMMRMGWEHRISQILKPDICKYSVSQGALGIEIKTKNRRMHELLRQLNHVPTLIRCIAERGLLKTLEGGCSAPVAVHSELEENRHSLDAET---NEEMKLFSSVIAPwvsqhaMQEAEALGVSVAKGLFDKGAGPILEAAKE-----
>UniRef50_Q2S2A6(3-308:323) Porphobilinogen deaminase n=1 Tax=Salinibacter ruber DSM 13855 RepID=Q2S2A6_SALRD  E=1e-99 s/c=1.19 id=47% cov=97%
-ISDPLVLGTRGSELALRQANVVRSRLEAA--GHRVELETITTRGDEATDTPISEIGDEAVFTKELDRALLQGGVDLAVHSLKDIPSTVPSGLALAAIGEREDPRDAFVAHPsfDGHLHDLPEGATVATASLRRTAQLLTWRSDLEVVPVRGNVDTRLEKLGESDWTGMVLAVAGLVRLGLSLHIRDRIDPSLIVPAVGQGALGIACREDQDALRDLLReTLHHAPSGHAANAERAFLKKVGGGCQVPLGAWAHIDDGTLVLDACIAALDGSEHYRDERRCAPEDGAAVGRKLAADLLAMGGDHILDDV-------
>UniRef50_C0YV01(2-300:302) Hydroxymethylbilane synthase n=1 Tax=Chryseobacterium gleum ATCC 35910 RepID=C0YV01_9FLAO  E=5e-98 s/c=1.20 id=36% cov=96%
---KSIRIGTRNSALALWQAREVARHLQNN--NYLTEIVPIVSSGDKNLNQPLYSLGITGVFTRDLDIALLNDEIDIAVHSLKDVPTQLPQNIEMIAYLERDYPQDILIRKESSRNKEFHE-LKLATSSLRRRAFWLRNYPTAEFSDIRGNIQTRLQKLEEGDFDATILSLAGIKRMKMEIDYEM---LPLMISAPSQGVISVAGHTDKPEINEIVRQINHQETQICVEIERNFLSTLEGGCTAPIGAFAEIIGDQIRFKAALCSLDGKNCIAVDENFVYTPAENFGEKYAKVVLENGGKELMAEIKS-----
>UniRef50_A8U3E9(15-320:321) Porphobilinogen deaminase n=1 Tax=alpha proteobacterium BAL199 RepID=A8U3E9_9PROT  E=7e-97 s/c=1.16 id=44% cov=96%
-----LTLGSRGSPLALRQTHEVRDRLAAAWPELagAIAVQEIRTTGDAVRDRPLAEIGGKGLFIKEIEQALMAGQIDAAVHSMKDMETTIAPASVLVAVLPREDPRDAWLSPIADRVDDLPSGAKIGTASVRRAAQVLNRRPDLQVVLFRGNVDTRLRKLAEGEVAGTFLAAAGLSRLGMLDKATRILEVDEMLPAVSQGAIGVQCRdgeasARDAEIRNWLSILDDRPSRLRVTAERAMLATLDGSCRTPIAGHATLGGARLTLSGMVFSLDGQSSHGAVDTSATDDPEALGRTVGEAILARGGRNFLA---------
>UniRef50_A6GB01(9-317:322) Porphobilinogen deaminase n=2 Tax=Bacteria RepID=A6GB01_9DELT   E=4e-96 s/c=1.15 id=46% cov=96%
-----LRLGTRGSALALWQANMIRDRLLAAWgaQGLEVELVRVVTKGDRVTDRPLNQVGGMGLFVKGLEDKLLAGEIDFAVHSMKDMPGTLPEGLTLASTPERADPRDAFLAAPGRdvTLATLPAGSRLGTSSLRRGALAKRINPGLEIVPIRGNVPTRMGKIAEGEVDAVLLAAAGLDRLGKGEAITERLDPDAFMPAACQGVLAIELRAADTDIAALFEPLGHGPTSIVAAAERSYLATLQGGCQVPLACHARLseDGRRVRVEGLVVEPDGSTVYASEAEGPVADAAQLGAGVAREVLAAGGQGVIDRL-------
>UniRef50_A8MDU3(2-303:305) Probable porphobilinogen deaminase n=2 Tax=Thermoproteaceae RepID=HEM3_CALMQ  E=2e-95 s/c=1.16 id=41% cov=97%
----IIRIATRGSALSLKQTKIVMDRILEFNKDVEFKLIIVKTTGDVDLSKPLYEIGVKGIFEREVNQAVLRGEADVAVHSLKDMPAQISNDLTLVMTPPRDNPRDALVSLRQYTVDTLPLNSIVGTSSLRRRGFLLSLRRDVTVKPIRGNVDTRIRKLNNGEYDALIMAAAGLERLSINANVSE-ISPELMPPAPGQGIIGVVARRDRDDLIKVLRRSSDEETFKEAAAERAFLSRIGAGCHVPLGGLALLDDGYFDFTYGVVDPDGVEKFINSTRIDARNPEEAGRVAAEDLLRN-ARGLVARLLK-----
>UniRef50_A0LRF1(8-318:331) Porphobilinogen deaminase n=1 Tax=Acidothermus cellulolyticus 11B RepID=HEM3_ACIC1  E=3e-95 s/c=1.13 id=42% cov=98%
---SVLRLGTRRSTLARAQTEEIAGALRAA--GCRVEIVGIQSTGDRHADVPLHEFAGSGVFVAELRAALLRGEVDVVVHSMKDLPTAEIPELAIAAIPRRADPRDALVTGAGCRLAELPTGAIVGTGSPRRAAQLRLLRPDLEIRPIRGNLDTRLGKLHAGGYAALIVAAAGLARLHRSEEAAEFFDPTVMLPAPGQGALAVECRradiADGGRLAGILAGLDDPATRAAVTAERALLAAVGAGCSAPVGALGVVTADTLQLDAVVVDPSGTTAFRRSLTGTPDDASDLGRRLAADLIRAGADQLLQAPKQTGEP-
>UniRef50_C1AA38(1-309:309) Porphobilinogen deaminase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1AA38_GEMAT  E=5e-95 s/c=1.13 id=50% cov=97%
MMTVPVRIGTRSSELALRQARQVAAQLDAR--GVPSELVEYTTLGDRILDRPLSAIGEKGLFTAELEADLLAGRIDCAVHSLKDLPTADPQGIIVVALLEREDPRDALVVRAGvdaHSLDTLPEGARVGTSSLRRRAQLQALRSDLEVCELRGNVGTRLRKLDEGQVDAALLAAAGLHRLGLADRIVAYLDAPEWLSAPGQGAIAVQGRADDEALLSTLSSLDHAPTRVAVTAERALLAALEGGCQVPIGAAVlEEPEYGTILHAVIVSLDGSSAVRGGYPVDHANPAASGIELARQLRAAGGAQILSEI-------
>UniRef50_B8MVK7(72-408:413) Porphobilinogen deaminase, putative n=1 Tax=Talaromyces stipitatus ATCC 10500 RepID=B8MVK7_TALSN  E=9e-95 s/c=1.04 id=41% cov=96%
---KAVRVGSRNSKMALIQTSSVAAALYKAHHGfFTFPVSTHSVQGDRDKTSAfrdLAKAHGnkqtaadtaKSLWTLEIEARLLAGDIDLIVHSLKDVPTTLPDGCEIGAFPHRNDPTDALLVKaglPYKSLEELPAGSVVGTCSVRRTAQLRHYCPHLIIQECRGNVDTRVAKLDANDspYTAIVVAAAGIVRLNLEHRITQRLSGPAYTYAVGQGALGIEIRKEDQKARELVACIDHWPTRVRCLAERALLRFLQGGCSAPIGVHSAFVrtpakgepnvndnhyEGTLYLTGTLLHPDGGMEIRAHEKGqvkCTADSETIGKSVGKKILDLGGAQILD---------
>UniRef50_B9L0Q4(1-294:560) Porphobilinogen deaminase n=2 Tax=Thermomicrobia (class) RepID=B9L0Q4_THERP  E=8e-93 s/c=1.16 id=44% cov=91%
-----IRIGSRGSTLALAQTEEVVERLRRLVPECSVTVVPIVTTGDRDRATSLTVLGGSGVFAKELHEALLAGTIDLAVHSAKDLPTQLPPGLVLVAVLAREDARDVLVTSPPRKLGELPAGARVGTSSRRRQALLQRARPDLIVVDIRGNVDTRLRKLREGIVDALVLGAAGLRRLSQADLVAEYLDPDEFVPAPGQGALAVVARESDGRL-ELLSRLDEPLVHEAVAVERAFLAAFGSGCSVPLGAYATIAGNRLRFRIAVLLPDGrfiSQCLDWPREEAIERARELGLTLA----------------------
>UniRef50_A4XK06(2-290:290) Porphobilinogen deaminase n=2 Tax=Clostridia RepID=HEM3_CALS8   E=1e-92 s/c=1.18 id=35% cov=93%
---KKLRIGARDSKLSRIQVDIVARKIKQT-LGIECEFVPIKTKGDIDKTKSLKDFKSPGVFVKEIELALLSREIDLAVHSLKDLPCEMDSNFEIVAVVEREDPRDVLVSKDGVGFYQLKPNAKIGTSSLRREVHLKNLRQDIQVVNIRGNIETRLSKIESEGLDGVVLAYAALKRLNLDSHVSYIFDVNEITPCPGQGAICIECLKDSPY-KNILSKINDADAYIQTQFERLVLKFLGGGCHSSIGVFCKTDQDKIYAFASILS--GDKLIKASIEGDKDDFLSLANKLSNMLKS-----------------
>UniRef50_Q8TXC8(1-298:298) Probable porphobilinogen deaminase n=1 Tax=Methanopyrus kandleri RepID=HEM3_METKA  E=5e-92 s/c=1.14 id=41% cov=95%
-MSETIRVATRSSRLAIIQTREVIELLERESPrDVEVEIVKTKSRGDVVRDRPLHKLGEKGVFVKEVDRLVLEGKADIAVHSAKDVPSVVDYPVDVAAVPPRRDPRECLVSRHG-GLKELPRGATVGTSSPRRRAQILLERPDLKVEPMRGNVDTRVSKVRRREYDAAVLAKVGLDRLGMTSEVSEVYDPEEFVPPAGQGALMITCRKDDDRVKRLLEVVDDEKSRVEVETEKAVVRELGVGCSEPVGVHVRARDGDhVRLVLGLFEEDGSCGHVLKMRGSPEDVVREAVSQAREVLSDG---------------
>UniRef50_A5CDH4(2-295:298) Porphobilinogen deaminase n=2 Tax=Orientia tsutsugamushi RepID=HEM3_ORITB  E=7e-92 s/c=1.15 id=43% cov=92%
----IIRVGSRASRLALIQAQAVVQKINDL-LGLNAIIIPIKTTGDLIQNKNLYDIGGKGLFLKEIEYALLNNTIDIAVHSLKDVPAYLPDGLQLAAVLERGDVGDMLVSKIANKITDLPLGAIVGTSSVRRRIQLLMLRPDLNIVLFRGNVDTRWNKIINNEVDATVLAAAGLQRLNYDtSRFCNIIPQSEMLPAIGQGAIAIEARKDDKLIMPLCAKINHQLTWQLIQVERGYLKTLNADCNVPIGGIASYIGNNsFEAKFMLGDYNMRYFFYSEVRGKLQHGYDIGVEAAK---------------------
>UniRef50_A8SQW4(39-350:350) Putative uncharacterized protein n=1 Tax=Coprococcus eutactus ATCC 27759 RepID=A8SQW4_9FIRM  E=1e-90 s/c=1.07 id=42% cov=82%
--KKTVKVGTRGSKLALAQTELVIKALNERFPQIDFQMVTMSTRGDRDTSRALLEFGGKAVFVEEFEEAILKGDIDIAVHSAKDMPMEIMEGLTISGTLPRACPQDVFIYKSGRSFDRNDSF-VVGTSSLRRQYQIRDMYPNAVCKNLRGNVGTRIQKLEDGEYDAIILAAAGLERLGViedkgndstecfevhkDELTFRYLSTESMLPAACQGIIAIETRTSGEAY-DMVRAINDTEAYTQLTCERAVLSRLNAGCHEPIGVYSELKGKHMKL------------------------------------------------------
>UniRef50_Q4T5L1(1-376:385) Chromosome undetermined SCAF9206, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4T5L1_TETNG  E=5e-90 s/c=0.89 id=46% cov=93%
------------SQLARIQTDSVAEKLKELYPDVHLEIVAMSTTGDKILDTALSKIGEKSLFTKELENALERNEVDLVVHSLKDLPTSLPPGFTIGAVLKRENPHDAVVLHPknaGKTLDALPAHSVIGTSSLRRAAQLKKRFPHLDFKDIvssercflpvqpghrcfflssrsqRGNLNTRLKKLDEKEdFAAIILAAAGLRRMGWDNRISQILEPEDCMYAVGQGALAVEVRAKDADILEMVSVLHDPDTVLRCIAERAFLKHLvqhthththththtrslavahwnlfclqEGGCSVPVAVHTKVKDSQLYLTGAVYSLDGSDSLKETMQtsvaapadGSPDEvdecarvgvtankipgeaqdrAERLGVDLAKLLLSKGAKEIL----------
>UniRef50_B0D5Q2(16-330:340) Predicted protein n=1 Tax=Laccaria bicolor S238N-H82 RepID=B0D5Q2_LACBS  E=1e-89 s/c=1.05 id=39% cov=97%
--QKAIVIGCRPSTLAKIQAELVRSRLKVLFPASRFEISSKKFPQPEIGTSQITERGGASLWTTELEDALFDGDIDILVHSLKDVPTKLKEGCEIIHVLEREDRRDCLVVKDGlpyRTLEELPAGSVVGTGSVRRVAQMKRRYPLLVIKDVRGNIDTRLQKLDSPDlpYTALILASAGLLRLSLHDRITSYLSPPISYPAVGQGCLGAEFRSADTKVKAMVSRLEVWQDGWAVRAERALLWVLEGGCAFPVGIWSSWSGDNIASEslSVMTSPDGSEEITVETTGvvaSVEEVLELGKQAARSLLEKGGRGIIVDL-------
>UniRef50_C9M5W1(424-711:714) Hydroxymethylbilane synthase n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M5W1_9BACT  E=3e-89 s/c=1.15 id=40% cov=92%
---RPLRLASRESELAMAQSRLVAERLHEA-TGFDVEIIPFRTRGDAVADRRLESAGGKGLFVKELERAILSGQADLAVHSLKDMPSSCPDGLAFAALMDRQTAFDCLVLRPGLTGRPV----RIGTSSARRIAQGRALFSDAQFVPLRGNLRTRLSKLDGGEFDALILAEAGLRRLGLQERVSRVFSADQMIPSAGQGTLAVQCPFDGP-VFDLVSQLDEPAVRTCCLAERAFIDRLNGGCTAPHGAYARVDGETIEMIGLYVRPDGKT-LSGKISGPAADGPSLAAELADRLKRRG---------------
>UniRef50_UPI000174444E(6-312:318) Hydroxymethylbilane synthase n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI000174444E  E=2e-88 s/c=1.07 id=44% cov=84%
--TDTLRLGTRGSELALRQAEMVEAALHAAHPYLRVERKVIATTGDKRPDLRFSEFTEgdrldKGIFTKELEIALASGEIDIAVHSLKDVPTVLDEKFFIAGVLPRAPIEDVLISREGYTLATLPAGAKVGTSSVRRIRQLQWLNPGVECVEIRGNVPTRIRKLFAPsDLDAILLARAGLERLSLLDgehvvvdgqpLHAVILDCEEFLPAAGQGAIGIEARVDDAHTLEFLKAINHEETYARVTAEREFLHILKAGCQTPIGAHTFLENGVLQMKVRVFD------------------------------------------------
>UniRef50_D2NS36(78-448:454) Porphobilinogen deaminase n=2 Tax=Micrococcaceae RepID=D2NS36_9MICC   E=3e-87 s/c=0.87 id=45% cov=94%
-------LGTRGSALALTQSRIAAETVTSLYTEhqahhgaadaevVDFTLRTVKTEGD-VLTGPLATLGGTGVFAAALRQRLLDGenaseenRVDMAVHSLKDLPSAPCPGLVIAATLKREDPRDALVARDGLTLDTLPEGSRVGTGSPRRAAQLRALRPDLEIVDIRGNVGTRIGRVkgleehagkqvvlrqntetseradhgvgteRSGDCDAVVLAVSGLKRLGKEELITEYLDPTRMLPAPGQGALALEVRESefenpdpavlaDPEVARPVRALgrallaaNHHETRLAVSAERALLRRLEAGCAAPIGAYAHVVEGDLVLSVVVASPDGTDMLRHTSATAELDvpgAERLGVRVAEDLLQMGAAAL-----------
>UniRef50_B6JII8(11-331:338) Porphobilinogen deaminase n=11 Tax=Bradyrhizobiaceae RepID=B6JII8_OLICO  E=4e-85 s/c=0.99 id=37% cov=97%
--DKAMRIGTRKSVMALAQTSEIARQLTAADPALDVEIVKFETTGDQDQTGKLLDLGGKgGAFVAQIRDAVREGRLEAAMHSLKDMPGnEDTPGLVIGATLTRDPPTDALVVRHGVTLADLrrtgGKGFKIGTNAVRRAAYVRRLFPECEIIHFRGAADTRIRKLDNGEkqrlpeggevgpADALVMAQAGLERVGCADRIAHCFSPDEILPAVGQGIVAVECAASDWCTLARLAQIDDPVSRCCAAAEREVLWVLNGHCNSPIAGYAIVEGDDVLLKAAVLDEANDHFIEVTRRGPASRPRELGRAVAFELLAKGAADVIAR--------
>UniRef50_C7DH16(1-300:301) Porphobilinogen deaminase n=1 Tax=Candidatus Micrarchaeum acidiphilum ARMAN-2 RepID=C7DH16_9EURY  E=6e-81 s/c=1.01 id=36% cov=96%
MSESEITIGTRGSELAVAQAEIVRNKLAAIEPRISFRIVKIKTLNEKV-DRSKART-EKDIYTKEIDEAILERRIDIAVHSLKDLKFNMDENMQIGAVPDRDDPRDVFIGNTETEFEHLGTDALVGTSSIRRRVQLTRINPKPMISDLHGNIDTRLSKLNSGEFSGIVIAAAGVKRLGKAVRM-QYFDERDVVPAIGQGAIAVTVHKDNSAAAELLKRIDNMKARVEVGEEIEFGKAFGTGCNLPIGANAKmLESGKIGIVGFVSDLAGKTLVKGETETGPGHA---GKSLAELLIKKGAGNLIER--------
>UniRef50_B5GJG2(31-332:335) Porphobilinogen deaminase n=3 Tax=Streptomyces RepID=B5GJG2_9ACTO   E=1e-80 s/c=1.00 id=38% cov=95%
---RTVTVGSRGSALARAQVREMVERWEREVPGVRFVRRVITEAGDADRSTPtvagVTRRAGVSAFSSRQEAALVRREVDVVVHCLKDLPTTPAPGTALLRTPgPREDARDALC---GATLAGLPRGARVGTGSTRRVAQLLALRPDLEVIPVRGNVPARLARLRT--LDAVVLAAAGLHRLGLTEEITEYLDPEAYPPAPGQGALAIQVREG-SGAARLLAASGDPATDTEVRAERVLLAELHGGCSVPLGTWtSRPSPGTLRLHAAVTAPDGGRQITATAQGPASEPDKLALTVAERLLAGGAARILAE--------
>UniRef50_D2RNT2(2-287:288) Porphobilinogen deaminase n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RNT2_ACIFE  E=4e-79 s/c=1.04 id=42% cov=91%
---KKLIVATRGSRLALAQTHIVCRLLEEA--GVETEIRTITTAGDRDRIHALVKIGGRGIFVREIERELLSGEADIAVHSAKDLPYQLASGLVIAGTPSQADPRDALVLLKERKLE---AGSVVGTGSPRRIREISRVLPELVFRDIRGNVTTRLHKLERGEYDAIVLAMAGIQRLALDMEQFQIrpLSTEQVIPAGCQGIIGVECRQKDRELVRLLQQISDPETWRRFQWERQLFTSMKVDCSRPVGIHCRlLKSGRMELLAMV---DGK---RARRLGMEKEGKALCASLKEELYDR----------------
>UniRef50_Q93A65(4-287:299) Porphobilinogen deaminase n=1 Tax=uncultured bacterium RepID=Q93A65_9BACT  E=2e-76 s/c=1.01 id=44% cov=89%
-----VRLATRGSRLALWQAEWVAKQLVQQ--GAEVELVVVETQGDR-EKRPFAQMQGQGFFTKAVQEAVLEGRADFAVHSYKDLPSARPAGLEIAAVPPREDPRELLLVRlqavdQVAPGLPLRAGARVGSSAARRQAQLAHLRPDLSLLELRGNVLTRVEKLRQGEYDAVLLAYAGVRRLGLDlsPFHWQVLPPTLLVPAPAQGALALECRQDDKRLRPLLEPLDDPSAGVRCGGA-GLMARLAGGCQLALGALAQETPEGLQLLA--WYRGRSYQARGS------DPEAVAEAVFKEI-------------------
>UniRef50_B0SF66(1-311:511) Bifunctional porphobilinogen deaminase/uroporphyrinogen synthase n=2 Tax=Leptospira biflexa serovar Patoc RepID=B0SF66_LEPBA  E=2e-67 s/c=0.83 id=34% cov=79%
-MSETIKIGGRSSLLSRIQIHTVTNALKEKNKDLNFETIFRESSGDKDLTTPLWQFGGQGIFTKDLQEDLLNHKVDIVIHSYKDMDLKERKETTLIPVLPREDVRDVLLFKKNKWIN-LPNEITILTSSPRREYhikeFLRNYFPtpinnfEIKIESVRGNIQTRLRKYLDHESGGILVAKAALDRiLNFQDPdqllpelkeiqqlikdtmnvsLFMVLPSSIFPSAPAQGALCAEIRKEDKHLETLLSKISDSETNLTTNEEREILSRYGGGCHQKIG------------------------------------------------------------------
>UniRef50_Q9PK95(20-214:242) Probable porphobilinogen deaminase n=13 Tax=Chlamydiaceae RepID=HEM3_CHLMU  E=1e-52 s/c=1.07 id=35% cov=62%
----PLRLASRKSPLAVLQAHECLRRLQTFFPRLWGQVITETTQGDLDQHTPLHSVENTGFFTDDIDFLVQSGKCDLAIHSAKDLP-EKPKARVI-AITASIDPRDILVFQEKYLLQPFPSRLRIGCSSDRRRALISSLYPSAVITDIRGTIQTRLALLDQQKFDAIVMANAAVSRLGLRLPCTVVLPPPYH---PFQGRLAI--------------------------------------------------------------------------------------------------------------
>UniRef50_Q6Q923(2-241:291) Predicted porphobilinogen deaminase n=2 Tax=environmental samples RepID=Q6Q923_9GAMM  E=2e-52 s/c=0.87 id=35% cov=74%
----TIKIASRSSKLALAQVEEFVKK----FGISDYKIIKVKTEGD-IKSANGETLFDKAHFVSDVQKCLLNGEADIAVHSAKDTPAGETTGL-LRYFLPSQSNQDVLIFREEDKFN---SEMKLGTSSLRRQLQAKHHLNAINIVNLSGNVDTRLEKLSQGEYDCIILAKAGLARLKLLNELQY--EVMDWSTASGQGFLCIEVLNDPSADIYnfLLKSIReiDLNLGKNISTERSILEAINAGCNSAI-------------------------------------------------------------------
>UniRef50_C0QU69(3-307:308) Porphobilinogen deaminase n=4 Tax=Bacteria RepID=C0QU69_PERMH   E=1e-123 s/c=1.46 id=56% cov=97%
-----IRIGTRKSKLALWQANYIADQLKKHFPDLEVELVKIVTKGDKILDVPLAKVGGKGLFVKEIEEAMLRNEIDIAVHSLKDVPTYFPEGLGLVAITEREDPRDAFLSVKYNSIEDMPEGAVLGTSSLRRKAQIMMKRKDIRIEDLRGNVDTRIRKLEEGQYDGIILAYAGLKRLGLEGKVRQILQPDYMIPAVAQGFLGIEARLDDEKTREIVSVLNHRESEIRAKAERAFLKTLEGGCQVPLAGYSEIVNGKLKITGFVSDLTGDRVFRDSMEGSLEDAESLGVKLAEKLLSDGAKEVLEEIYSG----
>UniRef50_B5YJZ4(6-311:311) Porphobilinogen deaminase n=2 Tax=Bacteria RepID=B5YJZ4_THEYD   E=1e-121 s/c=1.42 id=51% cov=98%
---NKIVIGSRGSKLAMWQANWVKDKLQTLYPELKVEIEKIKTTGDKILDAPLAKIGGKGLFVKEIEEALLSKRVDLAVHSMKDVPTEIPEGLQISAICEREDPRDAFISKDGVLLNELPQEAVLGTSSLRRTVQLKALRNDLVIKPLRGNVDTRIRKLKDGEFQAIVLAMAGVKRMGVENLVTQAFSEDLMIPAIGQGAIGIETRVDDDFVNELIKPLNHEETAICILAERAFLSVMGGGCQVPLACHARIVNNSLKIVGMIGDPEGKMpVIKGFREGSLSQAQSLGVELANELLHRGGKEILEKVYK-----
>UniRef50_Q8YVU6(10-316:323) Porphobilinogen deaminase n=50 Tax=cellular organisms RepID=HEM3_ANASP  E=1e-118 s/c=1.39 id=50% cov=97%
---RTIRIGSRKSQLALVQTYWVREQLQNSFPDINFEVHTMSTQGDKILDVALAKIGDKGLFTKELEVGMINEEIDFAVHSLKDLPTNLPEGLALAAITERENPADALVVHenfKDKQIDTLPAGAVIGTSSLRRLAQLRNQFPHLTFKDVRGNLNTRLAKLDAGEYDGLILAAAGLQRLGMGDRVHQILPKEISLHAVGQGALGIECRADDAELITVLKAIEHPETRDRCLAERSFLRSLEGGCQVPIGVNTEINGNELILTGVVASVDGQNLVKDTVSGNASDAEAIGIRLAELLREQGAQEILNTIF------
>UniRef50_D1BNZ5(1-305:312) Porphobilinogen deaminase n=3 Tax=Veillonella RepID=D1BNZ5_VEIPT   E=1e-117 s/c=1.39 id=47% cov=98%
-MRDHIRIGTRKSALALWQAEHISAELQRLYPNITVELVHFNTKGDRILEKPLAQVGGKGLFTAELEEAMHAGDIDIAVHSLKDMPTELPEGLTLGAISAREVPYDALVSPVYKTLDKLPQGARVGTSSLRRQAQLLHVRPDLKVEVIRGNVQTRLSKIETEKLDGVILAQAGLKRLGLEDQITQVFKADEMIPAVGQGALAIECRADDTEMLDMLDPINDEATRYAVEGERSFLRQLNGGCQVPMGVHGTINKGQLTLKAMIASLDGKTVYEGEISGPAKKGEILGKNLAKALYEEGGKRIVDAL-------
>UniRef50_C6HUG2(7-310:321) Porphobilinogen deaminase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HUG2_9BACT  E=1e-112 s/c=1.34 id=51% cov=97%
--SSPIRIGTRGSELALWQARHVAAMIR-HTAGLESELTIIKTTGDMILSVPLSQVGGKGLFVKEIEEALIAGTIDLAVHSMKDVPAFLPEGLEIGAILSREDPRDAFVSNAYSSFSSLPPGARIGTSSLRRMAQLKKRRPDLRFESLRGNVGTRLRKLDENQIDAIILAAAGLIRLGFSDRIREYLPVELSLPAVGQGALGLECRTGDHRIRTILARMHDPETTACVLAERGVLSALDGGCQLPIAAHARtISPEQIELIARILDVEGTTLLEEHTSGPAKEAHRLGVEAAQKLLSRGGQKILTDI-------
>UniRef50_C9R7U0(4-306:308) Porphobilinogen deaminase n=1 Tax=Ammonifex degensii KC4 RepID=C9R7U0_AMMDK  E=1e-109 s/c=1.31 id=48% cov=96%
-----LRIGTRGSDLALAQTEQVLQILRERWPHYTYEIVKIKTTGDKVRNLALPRIGGKGLFTKELEVALLEEKIDLAVHSLKDLPTELPEELCVGAVLPREHPGDVLISLTGAGLEDLPEGARIGTSSLRRQAQLKAARPDLNFVPLRGNVPTRLRKLEKGECEAVVLAWAGLRRLRLDLTGRMTlLPYQVCLPAVAQGAIGVEMRKEDRELRKMVEVLDDPTTRLEVTAERAFLRWLGGGCHVPIAALARVAGAEILLEGLVADPEGKRIVRGQESGSTAYPEEVGIRLAERLLREGAEELL----------
>UniRef50_D0LUE1(1-315:320) Porphobilinogen deaminase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LUE1_HALO1  E=1e-104 s/c=1.21 id=51% cov=97%
MSERTIHISTRGSQLALWQAHHVRDEIRRVRPAWQVELVIIKTQGDKILDVPLSKIGGKALFVKEIEQALLDGRADVAVHSMKDVPAELAPGLFMAATSRREDPYDALCTRDGRGLDELAEGATLGTSSLRRQCQILARRPDLRIEMLRGNVPTRLGKLDDGSFDAVILAAAGLKRLGHGERISQRLDGGVCVPAVGQGVLGIETRQGDapadrELVEALREALHDPAEERRVVAERAMMAALGGSCQTPLAAHASYRGdsdpvaGTLVIEGLCGRPDGSEILRAQVEGRAEDAQALGSSLAEELRGQGAQAIID---------
>UniRef50_C7N5L0(1-313:318) Porphobilinogen deaminase n=2 Tax=Slackia RepID=C7N5L0_SLAHD   E=2e-98 s/c=1.15 id=39% cov=99%
-MPERFVIGTRGSKLALWQTETVGRAIMRAFPEIEVEIRVRNTTGDINLASPLAEIGDKGLFTRELETDLLLGEVDMCVHSLKDLETEQPEGCVVAGVLPRADARDVLVcgpRIQAASLAEVPEGSRIGTGSRRRVAQLKANFPNMVPEGIRGNVDTRVAKAEGDDYEGAILAAAGMKRMGYEDHIAAYLPIEDMIPAPGQGAIAMEVLKKNERAYQIARALNDPVTKACTDAERFVLFSLEGGCSAPIGAHCRLEDGKYIFDACVLSLGGTKAARCHLEADADsaDPMDMAWEVVSELIGEGARAILRDIKNG----
>UniRef50_A3CL78(2-298:306) Porphobilinogen deaminase n=1 Tax=Streptococcus sanguinis SK36 RepID=HEM3_STRSV  E=5e-96 s/c=1.19 id=43% cov=94%
---KVIKVGTRKSKLAMTQTQQLVDQLKALHPERDFVLVPYTTKGDRLTHVSLQEIGGKGVFVKEIERALLAGEINMAVHSLKDMPAKLAEGCALGAISQREDVRDCLIFRQaGQTLADLPKGSLIGTSSIRRQVQLQAQRPDLAFKPLRGNIDTRIKKLEEGEYDAIVLAMAGLKRLGWLDQSRlhiQPLETSLCLPAISQGALAVECREEDEELLSLLAAVQDEKTAAEVAVERAVLAQMNADCTFPIAAFAQKNGQGYQLEAMLAKEDG-QCIFVSLQG--QDGQQLAEQAVRQLADKGA--------------
>UniRef50_B3DZQ6(2-297:298) Porphobilinogen deaminase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DZQ6_METI4  E=5e-93 s/c=1.16 id=39% cov=94%
---KPLIIGSRGSRLALIQAQLIVDSLKKEYPLLDIQIRVIKTTGDHLEAQPIRDIDQRGIFTKEIENKLLEGEIDLAVHSLKDLQVELHPRLVIAAIPPREDPRDCWISLQHPHPSSLQAGAIVVTGSPRRANQLLRKRPDLRIVPVRGNVESRLRKLRENrQWQGTVLALAGIKRLGIDisSFFCTPLSMDWMLPAPGQGALALQARIEDKHTQSLVKHLNDFSTACAVTAERVFLHELGGGCRTAVGARAEVEGSRLVLEGIWWPQQAIEPKEGKVVGEIHRAEDLGKKLADLLKN-----------------
>UniRef50_B8GXG1(6-319:322) Porphobilinogen deaminase n=8 Tax=Caulobacteraceae RepID=HEM3_CAUCN   E=6e-92 s/c=1.08 id=44% cov=96%
----PIRIGARGSKLSLAQSGLMQARIAHAlgvpagaskdEIEAAAPLIPIVTSGDRIQDRRLMEIGGKGLFTKEIEEALLDGRIDCAVHSLKDMPAELPPGLVLAATPEREDPRDAFISHVCERLEDLPKGARLGTASLRRQAQALHVRPDLEIVMLRGNVDTRLAKLERGEADAILLAQSGLNRLGLGHLTRSWLDPDACPPAPGQGALVIETRAEDIG-APWLEAVRCRQTTIAVAAERGALLALEGSCRTAIGARAILDGARLSMIVEALTPDGAQRFRREGDItltgadDIAEARAFGLTLGAEVRAAGGDAII----------
>UniRef50_A3MLK5(10-324:329) Porphobilinogen deaminase n=155 Tax=Proteobacteria RepID=HEM3_BURM7   E=1e-90 s/c=1.06 id=52% cov=100%
-LPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELESALADGRADLAVHSLKDVPMALPEGFALAAVMSREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRARHPRLDVRPLRGNLDTRLAKLDRGDYAAIILAAAGLKRLGLAARIRALLDVDDSLPAAGQGALGIEIAARRADVAAWLAPLHDHASALAVEAERAVSRALGGSCEVPLAAHAVWRGGELHLTGSVSTTDGARVlaaHAHARAATAADALALGRRVSDALERQGARAIVDALVAASAQA
>UniRef50_C4QMG7(8-307:411) Hydroxymethylbilane synthase (Porphobilinogen deaminase, putative) n=1 Tax=Schistosoma mansoni RepID=C4QMG7_SCHMA  E=1e-89 s/c=1.11 id=43% cov=87%
---NVVRVGSRRSNLALLQTGMAVNLLQKQNPHILFEVVEMATVGDKILDVSLSKIGDKSLFTKELENALLSGEVDLVVHSLKDVPSTLPSGLVLGCVFARVSPEDVVLmapHYRGRKLSDLPIGSTVGTSAVRRVATLTRKYPHLKFVSIRGNLNTRLAKLDtppaskdnccsgnpSPSYDAIILAKAGVERMGWSHRIDQVL--TDSFYAVSQGALACECRLVDNFIMDLLSHIHDESAALTTIAERSLMRQLDGGCSIPIGVRSDlvLKGDlnyyQLTLHANILSVDGGKSIERSAS------------------------------------
>UniRef50_Q57989(1-292:292) Probable porphobilinogen deaminase n=11 Tax=Methanococcales RepID=HEM3_METJA  E=9e-87 s/c=1.10 id=38% cov=91%
----MIRIGTRGSKLALYQANKVAELLKNL--GYKVEIKIIKTTGDRVLDKKLSDIG-IGVFTKELDLAMLNNEIDIAVHSLKDIPTIWNENLMVGAVLERDSYHDLLIWNKDIDFNE-DSKIVIGTSSMRRRAFLKFIYPNAKFELLRGNVDTRLRKLKEGLYDAIVLSEAGIIRLGvsLEDFNYKRLD---ILPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSVPFGALAVYDEKNelLKLKAAVVTNDELKNASGEVKCKIDEidkAVELGKKIGLKLKN-----------------
>UniRef50_Q5KKQ0(30-442:481) Hydroxymethylbilane synthase, putative n=2 Tax=Filobasidiella neoformans RepID=Q5KKQ0_CRYNE  E=5e-86 s/c=0.77 id=40% cov=98%
--TNTFILGTRKSNLALVQTGHVADDLRRLHSGagskfgetreegddaeqgdvpfvhpYTFSIESMTTVGDRNQTTPLHLLspysstqPAKSLWTDELEARLINGHFDMLVHSLKDVPTVLKDGCEIGCMAKRHDPRDALVVKQGlpyKRLEDLPDGAVVGTGSVRRVAQLKRAFPNLVFEDMRGNLNTRFNKLDNPQspFSALILAMSGLERLGMAHRATSPLSSPTLMHAVGQGALAIEIRSTDPRVRNCLRGLGHWQTEWSCGAERGCLRVLEGGCSVPVGVESELVEldedevaahpellegvedpfkgqeeiplegdspmlwfsglvdttsaptpstptfsshslpplrtrlAKLTLHSCVTSTDGSKHVLFTpppvLVRSYRQAEQFGEECARRLRGMGAGEILDEINK-----
>UniRef50_UPI0001BC2D4C(477-805:825) glutamyl-tRNA reductase n=1 Tax=Brevibacterium linens BL2 RepID=UPI0001BC2D4C  E=7e-86 s/c=0.97 id=38% cov=96%
---RTIRLGTRRSKLARSQSTAIAHQL-AALTGWRVEIVEVVTEGDVNM-SPLTGFGGTGVFVSAVRQALHQGKIDIAVHSLKDLPTTPEAGIQMAAIPPRVDPADVLIGRDGLSFAELPAGSVVGTGSPRRAVQLRAARPDIEVRGVRGNVDTRIAHVRDGRLDAVVLAAAGVRRIGRLAEATDSLDFDTMLPAPGQGALAVETRgadspfaldnevmEADAEVRTQLKRLHDETTDLAVTCERAILSRAEAGCSAPIGALATIQGSDFVVDAVMADDDGKLARTRQVaplpttpdvdldSGSANQLSITGKElarLADELGTAAAEDLLGQL-------
>UniRef50_Q6AHF1(15-322:329) Porphobilinogen deaminase n=5 Tax=Actinobacteria (class) RepID=HEM3_LEIXX  E=2e-85 s/c=1.03 id=39% cov=95%
-----LRVGTRGSPLAVAQTQAVSAAVARA-TGFDIELVTVTTHGDTSRE-SLSELGGTGVFATALRDALRNGECDLVVHSLKDLPTAPAPGLVLGAVPKRADARDTLCARDGLRFGELPEGASVGTGSPRRAAQLRAQRPGLDIVDIRGNVDTRLSRVSAGDLDAVVLAAAGLGRLGRLDAATDFFSLSTMPTAPGQGALALEVREGDERgrgpIARALAAVDHATTCAATTAERAVLAGLEAGCAAPVGATAMIDDGLLFLTATVYRPDGAAQLTASHAATPDSfgaahldeaARDVGERVVAELLASGAADL-----------
>UniRef50_A1DGB8(20-359:363) Porphobilinogen deaminase n=1 Tax=Neosartorya fischeri NRRL 181 RepID=A1DGB8_NEOFI  E=2e-84 s/c=0.93 id=40% cov=96%
--EEVVIFGCRKSELALVQTRWVTSKLgQTLDPSPTFQIATGSAVGDADKQAPFAVLSkltggsdiGKSLWTNELELDLVAGKVHCLVHSLKDMPTTLPPHCLLGAVPEREDCSDAVCMRsdlKFTSIDQLPPGSIVGTSSSRRKALVRRNWPHLEVVECRGNVDTRLAKLDAPSsrFSCILLATAGLLRLGLGHRITHRLDDSIFPYAVGQGALGLEVSTDRPDILELVRHVDHKPSRWRGIAERAMLRSLQGGCSSPIGVQSSLEplgkeengsteddsqrgrdsssGGNLSLRAMVLHIEGTSEIVAEDMATVrcdEEAELLGVSVANMLLAKGARGLM----------
>UniRef50_C7R376(2-344:344) Porphobilinogen deaminase n=1 Tax=Jonesia denitrificans DSM 20603 RepID=C7R376_JONDD  E=1e-81 s/c=0.89 id=42% cov=96%
---TSLRLGTRASALATAQSRATA-ALIAQATGVTVDLTHIRTDGD-VLTGSLATMGGAGVFVTAIRQALLAGDIDIAVHSLKDLPTTPHEGTTII-VPERENPQDALCSRHGESLAHLPHGALVGTGSPRRAAQLLVARPDLRIVDIRGNVDTRLARVglstadkphIRNDLDAVVLAAAGLRRLGRAHVISELLPPTSMLPAPGQGALAIEVRHDMADhhpsILAGIRTLHHQPTAYAVAAERAVLRHLEAGCAAPVGALATMhnttltltataLDPRLTPTAhtptpstttdinaaptpMTAPADARPPIRLTHThtvTSENDATEAGITLATTLLTHGAAEFLRD--------
>UniRef50_A3VPD5(1-286:324) Porphobilinogen deaminase n=1 Tax=Parvularcula bermudensis HTCC2503 RepID=A3VPD5_9PROT  E=2e-81 s/c=1.06 id=48% cov=89%
MSFKPLRIASRRSPLAVAQALWVRDRLAEAlgidevDRDAAFPHETFVTTGDRMLNPTLADIGGKGLFTKEIEIALLDGQADIAVHSMKDMPAQMPPGLVLAAVPVREDPRDAFVTLDGRPLDQMPAGARIGTSSTRRRAQLARLRPDLALVPMRGNVGTRLQKLAAGEAEGTFLAEAGLRRLGMTDVKREALSPARMLPALGQGALCVQARSGDHETLSACAHINNRPTALAAAAERALISGLDGSCKTPIGGLARQTGDSLILEGQILTPDGRRVLRGERT------------------------------------
>UniRef50_C7M2H5(3-287:291) Porphobilinogen deaminase n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7M2H5_ACIFD  E=4e-81 s/c=1.06 id=43% cov=91%
----PVRIATRRSALARWQASLVGERLGRY------ELVEVHTAGDRDQASSLAEIGGQGVFVKEVQAAVVRGEADIAVHSAKDLPTAAGP-LLLAAVLERADARDAIV---GARLEELAIGARVGTSAPRRAAQLRLLRPDLEVVSIRGNIATRLGRV--GELDAIVMAVAALERLGLEEPPWWPLPEEVLCPQAGQGAIAVECAPDADGLIERLRSLDDDRSRREIEAERAVLAAFGTGCALPLGARAHADGSSLRLRAVAVDPDGTRQLEVEREGV--DPATLGATVAEVLRRLGADALV----------
>UniRef50_C8WDJ7(1-288:308) Porphobilinogen deaminase n=3 Tax=Zymomonas mobilis RepID=C8WDJ7_ZYMMN  E=7e-78 s/c=1.02 id=41% cov=90%
-MQLPFRLGSRGSPLALIQARSVASALCAAHswSEDAVVIVPIRTSGDKNRHQALADIGGKALWTKELDIALTTGQIDAAVHSMKDVETFRPSHISIAAMLPREDVHDRLIG--IPSLEVLPYSGCVGTASPRRAAQIRRIRPDIEIKLLRGNIDTRLEKLANKQFDATLLAAAGLIRLGRNDVGYDV-PLDQMLPAAGQGAIGIEALA-DSAAWEKVSIIDHYPTHLAVQSERQLLLRLNADCHSPIAVFAEILEKNIRLRACLYTENGKFSASIDKEISqPSDAFEVG--------------------------
>UniRef50_Q8I5V3(58-413:435) Porphobilinogen deaminase n=6 Tax=Plasmodium RepID=Q8I5V3_PLAF7   E=1e-77 s/c=0.82 id=32% cov=95%
-IKDEIIIGTRDSPLALKQSEKVRKKIMSYFkkmnKNINVTFKYIKTTGDNILDsKSVGLYGGKGIFTKELDEQLINGNVDLCVHSLKDVPILLPNNIELSCFLKRDTINDAFLSIKYKSINDMNTVKsvsktedihhinkkdsdhnndtlcTIGTSSLRRRSQIKNRYKNIYVNNIRGNINTRIEKLYNGEVDALIIAMCGIERLikkanlkhllknkeqknicqpfllkcnnkkciDLCHVNIQKLNKNLIYPALGQGIIAVTSHKKNYFISSLLKNINNKKSEMMAQIERSFLYHIDGNCMMPIGGYTNMRNEDIYLHVIINDIHGYNKYQVTQKDTLYNYKEIGPNAAIKMKE-----------------
>UniRef50_Q1GP41(8-309:315) Porphobilinogen deaminase n=7 Tax=Sphingomonadales RepID=HEM3_SPHAL   E=2e-74 s/c=0.93 id=45% cov=95%
--DNPLRIGTRASPLAMAQAHMAAAALIAAHGLAmaALEIVPMTATGDRIQDRALAEVGGKALWTRELDAALDAGTIDVAVHSLKDVETLRDARFFLGAMLERADPRDRLVVREGiaaQKISELPHGARLGTSSPRRAAQVRRLRPDLDTVLLRGNVATRLAKLAAGEADATLLAAAGLERLGM-HDIGAVQGTELLLPAASQGAIGIECRADDAATIALLAAIDHAPTHRAVAAERALLAVLGGDCRSPVAAYAEWQaDGVLRLDAEIFSEDGADHVAGHVIVTDAGVVA---ALGHRLLAEAPPSI-----------
>UniRef50_A9V9E0(417-622:643) Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V9E0_MONBE   E=3e-71 s/c=1.32 id=49% cov=64%
-----IRIGTRSSVLAMWQTRWVVERLTRAHPGVRFSVVPLSTVGDANLTLDLNKFSTTGIFTDALVRALLAQEVDILVHSLKDLPSTISPGTQLAAIGPREDPRDVVVFHHRHSeikdLAQLPAGAVVGTSSTRRRAQLAAAYPQLRFAPVRGNVMTRLRKLDDpaNGYDALCLAAAGLIRLGLEARIGQFLPLTVSRHAIGQGALGIQV------------------------------------------------------------------------------------------------------------
>UniRef50_Q04X38(1-279:542) Bifunctional porphobilinogen deaminase/uroporphyrinogen synthase n=4 Tax=Leptospira RepID=Q04X38_LEPBL  E=2e-69 s/c=0.95 id=36% cov=79%
-MSRVLKIASRKSALAKLQTYLVLDALKKKFPNIQIELHFREASGDLDLQTPLWKMGTRGVFTQDLTKDLVEKKVDLVIHSWKDLDLEGHSGTTIVGVLDRADQRDVLLWKKSSLSKNFPSELKIQTSSPRREYNLKKFLNNslpsryknssLIFLPVRGNIQTRIRKWRNSDSDGLVLAKAALDRLlsedflnsneleyqeirkflkeILEESIFQVLPLSLSPSAPAQGAIAAEVRTDDEWALGFVRALSKPEVVSAVEEERNTLKRFGGGCHQKIGV-----------------------------------------------------------------
>UniRef50_Q4E9D5(1-197:199) Porphobilinogen deaminase (Fragment) n=1 Tax=Wolbachia endosymbiont of Drosophila ananassae RepID=Q4E9D5_9RICK  E=1e-59 s/c=1.18 id=41% cov=63%
------------------------------------------------------------------------------------------------CVLERLSPCDAFISHKHNSLESLPQQATIATSAIRRKVQLLNFRPDLNIVPLRGNVTTR---LQNQSFDGIILAEAGLIRLEKHHLITEVLPPKVMLSAVGQGAICIQCRRNDVKIIDLLEKINNNMSFIGVKSERSFMKTVNGSCFTPLAALAEYVsENMLYLRCMLA--DGKNIYFTERTSFIEDAEKMGMDAGLELKSK----------------
>UniRef50_C0DZX9(1-150:152) Putative uncharacterized protein n=1 Tax=Corynebacterium matruchotii ATCC 33806 RepID=C0DZX9_9CORY  E=1e-36 s/c=1.04 id=36% cov=48%
-----------------------------------------------------------------------------------------------------------------------------------------------------------MAKVHDGELDAVVLAYAGLSRVHRADEATEVFDPLEFLPAPAQGALAVECRADDADTIAAITTIADSKAYACAHTERVVLARLEAGCTAPVAAYATVaADNIMTLHAAVIAMDGSATLRATAAGPIDTAENLGMTVARALLDDGASSLLA---------
>UniRef50_Q1HRH6(1-111:349) Hydroxymethylbilane synthase-like protein n=1 Tax=Aedes aegypti RepID=Q1HRH6_AEDAE  E=5e-25 s/c=1.05 id=33% cov=32%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGWEKRIDQVIEPSEILYAVGQGALAVECRSNDEYILNMLSKLCHLETQCKILVERSFLKTLGGGCSAPVAVCtslkrkHDSKSNYLNIQGAVWSLDGKTEIRAD--------------------------------------
>UniRef50_UPI0000D537E6(49-273:356) hypothetical protein P700755_22735 n=1 Tax=Psychroflexus torquis ATCC 700755 RepID=UPI0000D537E6  E=2e-11 s/c=0.32 id=25% cov=24%
-------------------------------------------------------------------QSLRDGAGDLVAMSAFDWQQQDVEGLIIAGLLTRKEPTWVLVANDKP--EYLKQGAYILCDheLLRR--QMMRLRGDLTLE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A1AUE7(1-309:310) Porphobilinogen deaminase n=44 Tax=Bacteria RepID=HEM3_PELPD   E=1e-115 s/c=1.35 id=54% cov=98%
MPPRQLRIGTRASQLALWQANWVKSELEKRYPAMEVTLTKIKTMGDRILDVPLAQVGGKGLFVKEIEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVVSR-AARFSHLPPGARVGTSALRRQAQLLHARPDLEMVTIRGNVETRIRKLDEENLDAVILAAAGLKRLGLTQRVAEYLDVEFSIPAIGQGALGIECRLSDPVVTEAIAFFNHPDTSHAVRAERALLRRCQGGCQVPIAAHGTIRGGELRLVGLIAAVDGREFVRDEISGPVDQCEHLGEELADRLLSRGGRAILEEVY------
>UniRef50_Q180R9(3-295:301) Porphobilinogen deaminase n=11 Tax=Bacteria RepID=HEM3_CLOD6   E=1e-105 s/c=1.30 id=38% cov=94%
-----IVVGTRGSNLALIQTEWVINELKKKYPEISFEIKIIKTKGDLIQNVSLDKIGDKGLFVKEIEQQLLDGKIDIAVHSMKDMPSYLANGLKFAHTPKREDPRDVLILREGyKNLDDLPHGAVIGTGSKRRKFQLLKQRPDLNIVQVRGNVETRIRKIKDENMHGIVLAASGIIRANLQDKISSYLPVDVVIPAPAQGALAIEIRSNDSAIEGIVNSLKDENTEIQILAERGFLDGVNGSCHIPMAAYCEIIQDKIHLTGLYGDSEGKKVVIKSIDGDISSPRELGLKLAKLVLKE----------------
>UniRef50_A6Q7Y4(1-309:323) Porphobilinogen deaminase n=7 Tax=Epsilonproteobacteria RepID=HEM3_SULNB  E=1e-103 s/c=1.21 id=45% cov=97%
-MEK-LVIATRASNLALWQAYHIKERIETAFPEVRVELNEITSKGDKILDKPLALVGGKGHFTKELEDEMIAGNAHLAVHSLKDVPTYIPEGLELCAITERQDQSDVFLSHTYKSLSELPEGAVVGTTSLRRRMQLLEKRPDLKVKDLRGNVNTRLRKLKEGQYDAIILAYIGLYRLDLLKDIPYVEKLDFFIPPMGQAALGIEIVANNDRIREIAMTLNHEPTFICTKVERDFISVIGAGCSAPVAVNATMDKKEddkvptISVRAMIGYPDGTHILHKSLTVPLNEADILGDELAQAMIEEGALDILEQ--------
>UniRef50_Q11XT5(1-308:312) Porphobilinogen deaminase n=8 Tax=Bacteria RepID=HEM3_CYTH3   E=4e-99 s/c=1.18 id=41% cov=98%
-MNKTVRIGTRGSKLALWQAEHVAACLQTK--GLEPQIVIIDTTGDKILDQSLSKIGSKGLFTEELEEQLHAGTIDIAVHSAKDLQTHLKGGMYILAITERELVNDVLVSHKPIDTLKNNPDLIIGTSSTRRRALLRKFYPQAKMVDMRGNLQTRIRKMEEGACDAMLLAYAGMHRMGYDSLIKEKLSLEEFIPAAGQGTLAIEAAStlDKEKAAVIRAVLNDAATETAVSAERAFLRTLEGGCSIPVFALAVERDTDYLLTGGIVSLDGTKYLRKEIRFTAADAEQRGVELATVLLKDGADEILAEIKKG----
>UniRef50_B2W5W6(30-377:399) Porphobilinogen deaminase n=2 Tax=Pleosporineae RepID=B2W5W6_PYRTR   E=2e-97 s/c=1.03 id=42% cov=97%
----PVNIGTRNSVLAQIQARAVERSLKDAYPERTYNICPVIVQGDRDKITPLQQLSQgenaKSLWTGELESMLESGDLDIIVHCLKDMPTQLPDHLELGAILEREDPRDALLVsprlPKETTLATLPQGATIGTSSVRRAATLRKLYPHLKFADLRGNVGTRLAKLDAEDspYSAIILAAAGLKRMGLDNRITQYLSSTSggMLHAVGQGALGIEIRKNDEAMKELMSKIRCERTTRACSAERALLRTLEGGCSVPIGVETswkggkglsvgpqpakdydkhgnaveedepDVDDQELVMRAMVVSVDGKESVEYEATrkvRNAEEAEEMGREVAKILIEKGADKILEKIN------
>UniRef50_A6DBT5(3-293:295) Porphobilinogen deaminase n=1 Tax=Caminibacter mediatlanticus TB-2 RepID=A6DBT5_9PROT  E=5e-96 s/c=1.21 id=46% cov=92%
-----LTIATRGSKLALWQAEWVKKRLENL--GHEVDLKIVTTTGDKILDKPLASIGGKGLFIKEVEEALLRGEAQIAVHSLKDFPTEYnKEHFTLAAVPKREAVEDVFLSETFETLAELPHNAVVGTSSIRRAMQLKAFREDLVISDLRGNVDTRINKLKKGEYDAIILAYAGVKRLNLikEVKYFEILDTDIMIPAMGQGALGIET-IKDEKVIEAVKPLNDLWTKIEVTIERDFIDELNLGCHAPVGVNAKImVDDSIKIKAAILDKN-NKVIKKEMVVPFDEWENAGREFAEEFKE-----------------
>UniRef50_A2BL26(3-299:303) Probable porphobilinogen deaminase n=2 Tax=Thermoprotei RepID=HEM3_HYPBU  E=3e-93 s/c=1.15 id=43% cov=95%
-----LRVATRGSKLSIAQTMIALEAIKRVEPSLEYELVIVKTRGDIHQDKPFTAIGGKGLFEKEVNLAVLEGRADIAVHSLKDVPSAISPGLVLAMTPPRDPPYDVLVVRGGkeKTIWDLPSGAIVGTSSARRVAMLKHVRRDLVFKVLRGNVDTRLRKLEQGQYDAIVLAEAGLKRLGVDIEY-WRIPPDILPPAPGQGIIGVYTLSSRSDILPILEKASDQKAMAEARAERAFLAYAGGGCHTPLGAYAELRGNTLYFHAALASPDGSRRVEVRVEGDPDKPTQVGLEAAFELRRLAARE------------
>UniRef50_C1F251(1-311:312) Hydroxymethylbilane synthase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F251_ACIC5  E=3e-92 s/c=1.09 id=48% cov=91%
----MMRIGSRGSQLALWQANHIAARLRTLGHEVTIEI--IRTTGDALQHVTFAKvsteLGGKGIFTKEIEEALREGRIDLAVHSLKDLPTDLDPAFTLAAIPERVDPRDALLSARYTSLASLPHGACVGTSSERRRAQLLVHRSDLRFQEFRGNVDTRIRKMVEGQADAIILASAGLERLGLTEYRRECLAPEILCPAAGQGALAIETRADDAETLAILASLDHSATRYAVTAERTALASLGGGCQVPIGIHCAPVPG----------ADGAYAIQGVVAGAAAkaassaahpvirvafehqqglSPQALGRQLAEELLRQGAQ-------------
>UniRef50_A4QB59(2-300:302) Porphobilinogen deaminase n=15 Tax=Corynebacterium RepID=HEM3_CORGB   E=3e-91 s/c=1.13 id=40% cov=95%
----TLKIGTRGSKLATTQAGTIRDQLK--YFGRDAELHIVTTPGDVNM-SPVERIG-VGVFTQALRDVLHAGECDVAVHSMKDLPTAADPRFHLV-VPTRADSREALIARDGLTLAELPEGAKVGTSAPRRISQLKAIRPDLEILPLRGNIDTRMGKVTSGELDAVMLAYAGLTRVGMQDRATEVFDADIIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVLNRLEAGCTAPVAAHATLDgysGDTMTLTAGVYALDGSDQLVFSAEGDGARPEELGELVAQQLIDAGAANLLGD--------
>UniRef50_B9XN63(6-332:332) Porphobilinogen deaminase n=1 Tax=bacterium Ellin514 RepID=B9XN63_9BACT  E=1e-90 s/c=1.02 id=43% cov=93%
--NKPIFIATRGSALALAQANAVLSQCRSAFPKLDIELKIIKTTGDKLQKASLAKEGEslpKGLFTKELEVALLNGDADIAVHSLKDLPTELPTGLILGAVSKRADVRDVLVYRDAEYLrsqpgksnrrgftpklaiKDFPPGATVATSSTRRKAQLLAQRGDLNVVEIRGNVATRLEKLANqPELDATVLAAAGLERLNFkitaegklagegipEGLLATILDFDVMLPCVGQAALGMEIRENDARIQEICDRLNHPETHACVLAERSFLSGMGGGCQSPVAAYAEIAGDQLQMRA--ASFRETSARRAVGGKSINEAVALGQELAAKLK------------------
>UniRef50_Q7UPN0(9-337:337) Porphobilinogen deaminase n=1 Tax=Rhodopirellula baltica RepID=HEM3_RHOBA  E=2e-90 s/c=1.02 id=42% cov=97%
-----LRIATRESPLAMWQAEHVAKLLKK--HGFQTEIVPLVSKGDTDM-RPIDGTRQVGLFTKRIQQALVDDEADVAVHSLKDLPTEPDSRFVLAAVPPRESVLDALVFADNsphlesqtgaeSPLDYLPQGARVGTGSTRRLAQLKQLRPDLEVLPIRGNVQTRLAKLNAGEFDAIVLAHAGILRLEMTDLPHRLFPLDEMIPAPGQGALGIEVRSDDAGAMDAIANLNDAAARLAATAERKVLSELHGGCLAPIACHAKLEtsnhGTELCLRAIVMSADGEQRLQEDARITVQpndadlhvaEAHELGTLVAKRLRDKGADKLISTVRENH---
>UniRef50_D1BFI8(7-312:312) Hydroxymethylbilane synthase n=4 Tax=Actinomycetales RepID=D1BFI8_SANKS  E=4e-90 s/c=1.09 id=43% cov=95%
-----LRIGTRSSLLALTQTGTVADDLRRL-TGRPVEIVPVTTDGD-VLTGSLSQMGGTGVFVTALRAALLDDRCDVAVHSLKDLPTAGVLGLQHV-TPVRQDPRDALCSRAGHRLADLPHGARVGTGSPRRAAQLRLVRPDLDVVDIRGNIDTRLGRVhpETGDLDAVVLAAAGLNRIGREHAITELISVTDMAPAPGQGALAVETRssllEEDPVVARAFDQLDDPATSLSVLAERALLARLEAGCAAPVGTHATVSDGLLTLHAVVARPDGSEQLRHNQSTEVADtstaeAVALGEAVADHFLALGAASFI----------
>UniRef50_O29026(3-286:289) Probable porphobilinogen deaminase n=1 Tax=Archaeoglobus fulgidus RepID=HEM3_ARCFU  E=5e-90 s/c=1.17 id=41% cov=89%
-----LIVGTRGSKLALAQTNKVAERLKERY---EVEIRIVKTAGDIMKDKPLYEFKGMGAFVRALDTALAEGKVDVAVHSFKDVPSQRVEGTVVAAVIERDSPCDVLISRDGSTLEELDEGAVVGTSSLRRRAQLSRLRGDLRFENLRGNLDTRLRKLREGNYDAIVVAEAGLKRLGLDREVeYQPFPPEVIVPPANQGIIAIATRKGEE---DLVAFLNDEKTWLEAMVERAVIKELGVGCAVPVGVYAEAQS-RVRLICEILD---KKYLRVEEKlskdTAVEEAAEIGKDLRKEI-------------------
>UniRef50_C0BZ93(1-291:298) Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM 15053 RepID=C0BZ93_9CLOT  E=3e-87 s/c=1.11 id=40% cov=93%
-MQSIIRIGSRESRLAVKQAEIVKQAVERNCPDIKAEIVTMKTEGDKILDRRLELAGGKGLFVKELEKALLDGRIDICVHSLKDVPMEVPEDLPVVAFGEREDPRDVLIYKPGRT--SIPEGGVIGTSSRRRELQLKRLYPSCTFRSIRGNVQTRLRKLSEEGFDGTVLAAAGLKRLHMEEVAGRVFSVDEIIPAVGQGILAVQGRKGRDY--SWLTSFACGKSRAEAEAEREFAAALGGGCTSPVAAHAQAQGAELKLTGLYYC-GGDIYRTRTRTGETDRARQLGAALAEEMRRE----------------
>UniRef50_C5CB88(2-355:377) Porphobilinogen deaminase n=5 Tax=Actinomycetales RepID=HEM3_MICLC   E=1e-86 s/c=0.91 id=44% cov=95%
---SPLRIGTRGSALATTQTSHVAEALTAR-SGLAHELVVIRTEGD-VTTGSLASLGGTGVFASALRAAVLDGVVDAAVHSLKDLPAAQPETLEIAAVPARADLRDALCARDGLTLATLPEGARVGTGSPRRVAQLKALRPDLELVDIRGNVQTRLARVpgleqhddhapaavgsPRGDLDAVILACAGLDRLGLDHVITERIDPEVMVPAPGQGALAMEIRAEDEsflgralldpeapvgRLHAALELVDDRDTHVAVTAERALLRRLEAGCAAPIGAVARVGDGEagaprIEMTAMVAALDGSRVLRrtssvqldpvpADVVGDPAaadewledtlfvAAEALGVHVAEQFVAEGAD-------------
>UniRef50_Q8D2W2(3-291:291) HemC protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis RepID=Q8D2W2_WIGBR  E=8e-86 s/c=1.10 id=46% cov=92%
-------------------SKLCKKKLLHYHPKLNIKLVPILTTGDLINKIRNNITNEKGLFIKELEKSLLKYQSDIAVHSMKDFSSSFLDSLGLAAICKRDDPRDAIVSNYYNNIISLPNNAKVGTSSLRRKCQLLSIRPDLKIFPCKGNIHSRLKKLNQGVFDALILATAALKRLKINEQMYTPIDPSYLLPAMGQGSIAIQCRLYDNKIIDIVRNINNKKTALCINSEKIVVSMLGTGCRVPIGSYAKIENkNTIWIRALVGSIDGSNIIRSEGKSCVSNAEKLSKKQVKNLINLGAKNILKK--------
>UniRef50_D1C4S0(11-309:311) Porphobilinogen deaminase n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C4S0_SPHTD  E=3e-85 s/c=1.06 id=42% cov=95%
-----VRLGTRGSALAREQTRRVMAALAALRPDLELIETIVSTAGDRDKRTPLTVIGGQGVFARELQTALLAGTVDVAVHSAKDLPTEPVPGLVIGAFFSREDARDVLVSRDGRSLADLPPGARVGTSSRRRLVALRRLRPDLEAVDLRGNLDTRLRKVREGEVDAAILAAAGLLRMGWQEHITEFLSLDDFVPAPGQGALAIECRADDPAVNEMLAALNDPAAALAARTERSFLRALGGGCRSPIGAHATVSGDTVTLRVMLGDEAMTRVRLSTWTLPAAEAETRAGALAVEVQRslAGADPL-----------
>UniRef50_A8PWJ5(89-482:530) Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8PWJ5_MALGO  E=6e-85 s/c=0.80 id=44% cov=97%
----TLVLSSRKSELAVRQATQVqmlldtrygraspvfapgadqwpstevaniRAFLRTFSPDqkdvrpVDFPVRTMATLGDQNLKSPLYVIGGEGraIWTKELEVALMAGGVDAIVHSLKDVPTTMPDGVELAAILEREDPRDALVVKEnlpYKSLQEMPQGSVIGTSSVRRVSLLRRAYPHLMFSDVRGNINTRLAKLDaaDGPYTALVLAAAGLKRMDLEHRITAYVSEPVMLHAVGQGSLAIEVRtprgesaERDERIRRMIRSISNWRATWRCVAERALMHRMEGGCSIPLGVSTRFEDHAdiegllnernetpsemasagisrpdiriahepppqgsfLTMAAVIVSLDGTRMCKHSHTQlcrSEKDAEQLGILVAEELEhHQNARAILAEV-------
>UniRef50_Q0ATQ1(5-307:321) Porphobilinogen deaminase n=3 Tax=Alphaproteobacteria RepID=Q0ATQ1_MARMM  E=6e-83 s/c=1.02 id=44% cov=93%
--SRPLAIATRRSPLALVQARDVQAKLAAqcglsgEDAERCFPILGLVSTGDRIQDRTLIEAGGKGLFTKEIDEAQLDGRAAFAVHSMKDVPTVLPDGIVLGALLEREDPRDMLIARDGETrLADLPEGVTIGTASLRRQAQLLHKRPDLHVVPLRGNVDTRLGKLADGGIHATFLARAGLNRLGRAEALRDPLEADEMLPAAAQGAVGVAIRDGDEEAASYVAGLHHRDTELAVLAERAFLFELDGSCRTPIAAHVNKVS--MDFIGEVLTPDGQQSWRRQIRfdmthATPDSARQAGQDLGRAVR------------------
>UniRef50_Q2FTK7(2-289:295) Hydroxymethylbilane synthase n=3 Tax=Methanomicrobiales RepID=Q2FTK7_METHJ  E=2e-82 s/c=1.07 id=39% cov=92%
----PLRVGTRASELAKAQAVKVCTMLEDL--GVDTELVFISTAGDEQTGVPLHEIGGQGVFVRALDDALVQNKIDLAVHSMKDIPAERPYGLVTSAILARDSPCDYIVTDH-----ELDEITTLGTSSTRRTAQCRRNLPWADIRPLRGNVNTRLSKLQSGEYDAIMLAKAGLERLSMTLDGYQ-LDPRVHVPSPNQGTIAVVSRT-DPDVTDIISKIDDPKTRMDTLLERRVMEMIGGGCFTPLGIYCKDR----LMIAEVLSLEGDRHFRLERlVSDIDDADRFGLEVRER-----AGDLIREAYE-----
>UniRef50_A4YD92(3-287:290) Probable porphobilinogen deaminase n=1 Tax=Metallosphaera sedula DSM 5348 RepID=HEM3_METS5  E=8e-82 s/c=1.07 id=39% cov=90%
-----IRIAARGSKLSLKQVEIVTTYLQAK--GYETEFIEIKTKADLFGNKPLHEIG-KGVFEKEVNEAVLQGRADIAVHSMKDMSSELPPGLELLATPKRENPVDVLVSE--LNLEELPEKSRIGTGSLRRANFLKVVRPDLVVENIRGNVDTRLRKYRDHEYDGIILAEAGLRRLGVEVK-RFPLDVESFTPEPNQGIIAVV---GSPKFLGLFQELNDTGTMKEALAEKETVKVVGGGCHSPLGVLFRLEDD--VLHGIASYSNGVKRVTVklsTRESPQIAGNQLGKALVKAMKDEG---------------
>UniRef50_Q9HMY5(1-393:396) Probable porphobilinogen deaminase n=2 Tax=Halobacterium salinarum RepID=HEM3_HALSA  E=6e-79 s/c=0.75 id=40% cov=97%
MSSQQIRLATRGSDLALRQAGEVVDTLEDRR--HDVELVEVETEGDRVTDALISDLGKTGAFVRALDQEVMEGTVDAAVHSMKDVPTEVPEDLVVAAVPHRENPADVLVTPDGTDLEDLPAGSVVGTASLRRGAQVQAHRPGLDVEPIRGNVGTRVEKLlapalhreherrteaekeaqsrdareqrrgdytadieagvenldtedgeegaaDDGddtasssefeqsvtewfdsltplqqsamerdpdtEYDALVMARVGLERTGLLHHVGiEELSTGTHVPATGQGALCVTARRDSDVVDTLRDALEHVRTRVEVTAERVVLEELGGGCIAPIGVHALVQGDTIRTAVQVFSQDGSEQVGETRELDAEQYATDARELAADLRDRGAADLIED--------
>UniRef50_B5JN62(10-286:291) Porphobilinogen deaminase n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JN62_9BACT  E=2e-78 s/c=1.06 id=40% cov=88%
-------IATRKSPLAMAQTHLAKELFQRGMPDAVFRIEKMVTTGDKRQEWSLEKQGGKGLFTKELEDALLEGRADFAVHSAKDLPSEMPKGLALAGFLPRQTCEDVLILRDGVESPKL-----IATGSPRRRIQLRYLFPKAEFTEIRGNVDTRLTKIARGDADATVLASAGLNRLGiesWEGVTFRKLTLDECVPAVGQAAVAIQCREEDVDTFRAHL---DEETAIAVNLERSFLEELGGGCQVAFAV--NYVGGRLRI---YHKQCGKEVRDLPQEYVATHYEQIAAKLIEQL-------------------
>UniRef50_B4UXX3(1-230:231) Porphobilinogen deaminase 2 (Fragment) n=1 Tax=Streptomyces sp. Mg1 RepID=B4UXX3_9ACTO  E=9e-59 s/c=1.00 id=40% cov=70%
MMTSstdltTVRLGTRPSPMALEQTGRFADVFRARYPQVVLDIVEIVSEGDRHRG-PLSTIGGKGAFTRNADRYLLDGRVQATIACAKDVPGPHDrsPGIVIAAVLPREDTRDALVLPTGhpvTTLAELPPGTRVGTSAPRRSALLKALHPTLVQVPIRGNADSRLRALDAGRLGAdvMIAALAGLRRLGHEDRASEILDPAVWLPAAGAGTVIVEHRSDDPATGWLLAPL----------------------------------------------------------------------------------------------
>UniRef50_UPI0001698669(8-135:136) porphobilinogen deaminase n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2' RepID=UPI0001698669  E=4e-27 s/c=0.97 id=52% cov=39%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGLKRLGFEQRITAFIAPEQSLPAIGQGAIGIECRSDDAQVNALIAPLHHVDTAACVHAERAMNNRLMGGspC-----ADCRLRDAGVPATsGCVVWWARSTVARscvGEAEGTPDEAESLGVGLAERLLELG---------------
>UniRef50_B8N6H4(10-88:90) Putative uncharacterized protein n=1 Tax=Aspergillus flavus NRRL3357 RepID=B8N6H4_ASPFN  E=2e-20 s/c=1.29 id=38% cov=26%
----PLRIGTRRSNLAMVQAEGIRNCLQKIAPGRSFEIEALRTLGDRDQLTALYNFGAKSLWTTELEEKLNAGELDVIVHCLK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q65GK1(2-305:313) Porphobilinogen deaminase n=98 Tax=Bacillales RepID=HEM3_BACLD   E=1e-114 s/c=1.36 id=48% cov=96%
-----IIVGSRRSKLAMTQTKWVIKKLEELNPDFTFEIKEIVTKGDRILDVTLSKVGGKGLFVKEIEQAMLSGEIDMAVHSMKDMPSVLPEGLMVGCIPKREDARDVLISKGRQKLADLKQGAVVGTSSLRRSAQLLQMRPDLEIKWIRGNIDTRLKKLETEDYDAIILAAAGLSRMGWkDDVVTEFLDPESCLPAVGQGALAIECRGSDEELLSLFSRLNDRYTQLTVTAERAFLHAMEGGCQVPIAGFAKMDeDGVIELTGLVASPDGKTVYRETVKG--KDPEAVGRECAAVMSEKGAKALIDRVK------
>UniRef50_B6FXV9(3-299:299) Putative uncharacterized protein n=1 Tax=Clostridium hiranonis DSM 13275 RepID=B6FXV9_9CLOT  E=1e-103 s/c=1.27 id=38% cov=95%
-----IRVGTRGSNLALIQTNWAIDRLKEKFPEVEFEVKIIKTKGDKILHLSLDKIGDKGLFVKEIESQLLEGEIDLAVHSMKDMPAEVVEGLKFAAVPKREDPRDVIILREGlNSFDELPIGATIGTGSKRRKYQLLRKRPDLNIVPIRGNIETRISKIESENLDGIVLAASGVIRADLEEKITEFLPVDLMIPAPAQGALALEIRENDEELEKMIDAIKDEISQIQTDAERSYLAGIDGSCHIPMGAYCEVDGEKLTLTGIFGDEDGEKITVASLEGDRDNPKELGSNLAKLVLKKHREE------------
>UniRef50_B3T8H9(18-322:322) Putative Porphobilinogen deaminase, dipyromethane cofactor binding domain protein n=1 Tax=uncultured marine microorganism HF4000_APKG5H11 RepID=B3T8H9_9ZZZZ  E=1e-100 s/c=1.21 id=40% cov=96%
-----IKVGSRGSTLALIQDHVVINRLKANSPALEFEVDTVRTRGDVDQTSRLAGMG-LGIFVKELEQELLDGKLDIAVHSLKDMPTQLADGLVLGAVLSREDPRDVLVNRYGCPLDGLPKGAKIGTSSPRRAAQLKQYAPQVEVVSIRGNVETRLRKAQGEEADGAILAAAGMIRLGLQDQIAEYLSATQFVPPPGQGILAVEARADDFRMLELLSAIDDADTRYEATAERGFLARLGGGCSIPVGAYARCNGDNIVMTIYMSTADGEKKFSAKIQGLKRDPLQLANDAYLALVERGGADLVA---------
>UniRef50_C6WZF5(10-310:311) Porphobilinogen deaminase n=1 Tax=Flavobacteriaceae bacterium 3519-10 RepID=C6WZF5_FLAB3  E=1e-100 s/c=1.22 id=36% cov=96%
-----IKIGTRNSPLALWQAREVARHLQNN--NHTTDITPIISKGDKNLSQPLYTLGITGIFTKDLDIALLNNEVDIAVHSLKDIPTQLPENVEIIAVLQRDYPQDVLVRKKDAATLELHQ-LKIATSSLRRRAFWLKEFPGTEFSDIRGNVQTRLTKLEENDFDATMFSLAAIERMGLSVDYEH---LPLMIPAPAQGVVAVCARSNDPEIKELFKEINHRETRICIDIERSFLSTLEGGCTAPIGAFAEINDlGEVRFTGRICSLDGQNCIETDEIFAWNEHDDFGKILAEKILQNGGRELMQEIKSK----
>UniRef50_D0NJW2(13-332:361) Porphobilinogen deaminase n=2 Tax=Phytophthora infestans T30-4 RepID=D0NJW2_PHYIN  E=3e-96 s/c=1.11 id=40% cov=99%
--KRTIFVSSRKSQLAMAQTNTVIAMLEERFPDLQFVVGQEDTVGDQVLDRHLSDLGTTtasGLFTKSLEEALLAKAASFAVHSLKDMPTTLPDGLVLAAITKRESPEDAAVIHPKhkekgiKTLQELPEGSVIGTSSLRREALLRSQFPTFEIKTVRGNIQTRLAKLDEhDDYDAIIVAACGFRRGELGDRIDEILPMDTFGYGVGQGSIGVECRADDEETIEMLKTITDEKSAQLCKAERSLLYHLEGGCQIAMGVSATLDEDTLTLNATVLSRDGKESVHETISGPRTQCEELGKQLAERFWNNElARKVLGKTRQKRA--
>UniRef50_C4ZFT9(5-313:338) Porphobilinogen deaminase n=1 Tax=Eubacterium rectale ATCC 33656 RepID=C4ZFT9_EUBR3  E=8e-94 s/c=1.12 id=42% cov=86%
-------IGTRGSKLALVQTDYVIDKLKRAYPDDDFKAVIIKTTGDLEQKKALDKIGSKGIFVKEIEDELLSGKIHMAVHSMKDMPDEPAAGLTFAKAWKREDPRDVLVLKNAASLDELPHGAVIGTGSKRRKYQLLKLRPDLKVVGIRGNIDTRLRKLYDGEiiyeevadntvnnneianekknkyseyrLDGIVLAAAGIKRIGRDSEITQYFSEDDMIPAPAQGTLALELRADNAKLMAKLDALSDEKTNLCAGIEREFLKQIGGNCHLPVAAYCDIvsekdrgndsnKNNRLKLLAMFGSEDGKQLARTE--------------------------------------
>UniRef50_D2RH82(1-288:292) Porphobilinogen deaminase n=2 Tax=Archaeoglobaceae RepID=D2RH82_ARCPR  E=1e-89 s/c=1.15 id=39% cov=91%
-MSERVVVGTRGSKLALAQTSKVVERLKEE--GYSVEIRIIKSTGDIMKDKPLYEFKGSGAFVRALEHALVRGEIDVAVHSYKDIPSNMLEGVTVSAVLERDSPYDAFIARNGESLEEIKPNAVIGTSSLRRRAQLKLYRSDLRFENLRGNVDTRLRKLREGLYDAIVLAEAGIQRLGLNVKY-QRLPIERFVPPANQGIIAVQTRVGEE---DLVKFMNHEETWIEAEVERIVMKTLGVGCAIPAGIYAECR-GKVRLIVQVIR-DGREfkvIEELSRESAIEEAREIAENFREEV-------------------
>UniRef50_B3RTQ8(4-306:314) Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RTQ8_TRIAD  E=3e-89 s/c=1.09 id=44% cov=87%
MEETVVRIGTRKSQLAMIQTHSVVDALREIHPKARIEIVTMDTIGDRVLDKALPEIGQTNLFTKDLEVALTDNKIDLIIHSLKDVPSTLPEGLAIAAI-----------------------GNVIGTSSLRRIAQLKRRFPHLKFENVRGNLNTRLKKLDEsGIYDALVLAGAGVE-----------LTPDECLYAIGQGALGIEIRKNDKKTFSLISAYTDFDSLVCNAAERAFLRFLDKGCSVPIGVYTEFTENKLKITGAVFSLDGSKRVQYSDECTISglnakddcesnyeslssilcpsemcnsliEAERLGKYVAEMILKNHGGEVLAE--------
>UniRef50_Q47LA7(1-316:320) Porphobilinogen deaminase n=3 Tax=Actinomycetales RepID=HEM3_THEFY   E=1e-88 s/c=1.04 id=41% cov=98%
MSTTPARLGTRRSTMATNQSRRVAEILTAR-TGVPVELVLITSFGD-ITRAHLTQLGGTGVFVSALRDALLAGEVEFAVHSLKDLPTAPTEGIVLAAVTERDDPRDALCARDGLKFADLPPGATVGTGSPRRVAQLAALRPDLRYVPIRGNAETRLGKVASGELDAVVLAYAGLHRVGRLDDVTDVFDVDQVLPAPGQGALAVECRTADfTGPLRYLTAVDHLPTRAAVTAERVILAELEAGCAAPVGAYAEFVaEDRLRLRAAVVATDGSQAVRAEQTVTVTEfpdavqaATALGRQLAHDMIEQGADQIVADAAAG----
>UniRef50_C6XST0(2-261:526) Porphobilinogen deaminase n=2 Tax=Pedobacter RepID=C6XST0_PEDHD   E=1e-88 s/c=1.26 id=45% cov=81%
---KRLIIGTRGSDLALWQANFIKDKLAAI--GVEAELKIIKTQGDKILNLRLDKLEGKGFFTKELEEELLGGTIDIAVHSHKDLPTVHPAGLTIAAVTEREDPSElLLILKDCVSINhklSLKKGAMVGTSSNRRKAQLLALRPDLNIEDLRGNVPTRIQKLRDEDYDAILLARAGVNRLNidLSEFHVEVVDTTELVPAPAQGALAIQIRENENELFDILQQINHSETAEEIAIERKVLNLFEGGCHMPLGCYCKKEDGQ---------------------------------------------------------
>UniRef50_B3LB83(65-431:449) Porphobilinogen deaminase, putative n=1 Tax=Plasmodium knowlesi strain H RepID=B3LB83_PLAKH  E=2e-83 s/c=0.85 id=34% cov=94%
---KEIIIGTRDSPLAIKQSEKVRTKLEAYFkkvnKNVKITLKSIKTMGDNILDQKVDLFGGKGIFTKELDEELIKGKVHICVHSLKDVPMELPEQVQLSCFLKRDTINDAFLSVKYGTLEDMnkmkmankmeegsyqPKGMsqrvinqnvkrdnyegdhydnfipTIGTSSLRRSSQIKYKYKNVAVKNMRGNINTRIAKLCNGQYDAIIIAKCGLERLttkkgirniiggknkvtpknflinynnteiNLTSLHIQQINKRTIYPALCQGIIAVSSHKSDKYISDVLKNINDEKAQIMANIERSFLYQIEGNCMMPIGGYAKIVNGEIVFNAVINDIHGREKYHVREVGKVESYNEIAVMAATKMKEK----------------
>UniRef50_Q9Y9J0(3-293:307) Probable porphobilinogen deaminase n=1 Tax=Aeropyrum pernix RepID=HEM3_AERPE  E=2e-75 s/c=0.98 id=37% cov=92%
-----VRVAARGSRLSLLQVEQALEEL-SRYAGVSMhwEVVRVKSAGDVWSDRPLESIGVVGVFTREVDRAVASGAADIAVHSLKDMPTSGYGGpLKIVYIASRPSARDALISRQGPgRVEDLEPGSTLGTSSARRRALSLHYNPRIRVENLRGNLDTRLRKLREGLYDAIIASEAGLIRLGVDVEYT-PLDPSYFPPAPGQGFVAVVARVG-SNVEKMLRDLDKPPWWHVAWAERGVLEGARAGCRTPVAAYAEPLGRSMvRVTAAALSPDGSRAYWARAEGRIEEARRIGVSLGEEL-------------------
>UniRef50_C5C5B3(18-294:334) Porphobilinogen deaminase n=6 Tax=Actinomycetales RepID=C5C5B3_BEUC1  E=8e-75 s/c=1.02 id=44% cov=84%
--TRTLRVGTRASALATTQSEWAGEAIAARVaaatgSDVEVELVRVTTTGD-VLTGSLASMGGTGVFVTALREALLDGRCDVAVHSLKDLPTAAAPGLVLGAVPQREDPRDVLCARAGAGLADLPAGGRVGTGSPRRAAQLRRARPDLEIVDIRGNVDTRLSRISpgKGDLDAVVLARAGLARLGRLDAVTEALDAGVMVPAPGQGALAVEAVdAAPDWLLAGLRAFDDAPTRLAVTAERAMLARLEVGCSAPVGALATLAGSQLLLRTSVG-------------------------------------------------
>UniRef50_B1ZV87(2-250:284) Porphobilinogen deaminase n=2 Tax=Opitutaceae RepID=B1ZV87_OPITP   E=3e-67 s/c=1.04 id=39% cov=79%
---KKLILATRKSPLALRQTEMVAAHLEAR-LGVQTELLKLVTTGDRQTEWSLEQKGGKGLFTSELENALRRGEADLAVHSTKDLPGDMAAELAVAGYLPRADARDVLVLRAGVA-----APKSLATGSPRRRLQIAKLYPGVTFTEIRGNVDTRLKKIGElGVADGTVLASAGLNRLGIGNWPGvefHALGFNDMVPAVGQGAIAVQCRAADAA---RFAPVFDAATKRAVDVERAFQAALGVGCQTAFGAH--VAGDTLHF------------------------------------------------------
>UniRef50_C0EAN0(12-290:292) Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum DSM 5476 RepID=C0EAN0_9CLOT  E=2e-63 s/c=0.88 id=31% cov=89%
-MEK-IHIGCAQNELSRNFADHLAQCLHSYHPELTAELVPIKNTGADEEPT---------LVARRLEQALIDCRVDLAVYHALDLPLELHPELPIVAISSREDVRDALVFPQGK---QQPDFSKpIGCTSRRQQVQLHRVFPDCITAPVGGTVAEQLARLDQGEYGALVLPAAQLGWFGLQQRVGQLFCVEELVPAAGHAAIAVQARE--EFDAGLLECFHSWDSWDAVFCEREFARALEEE-PGPIAVHAEVKGETLSVVGFYADEAEGIYRMSSMSGDRKDAGRLGFELAAELK------------------
>UniRef50_A8CBG6(160-735:747) Porphobilinogen deaminase n=3 Tax=Toxoplasma gondii RepID=A8CBG6_TOXGO  E=3e-63 s/c=0.42 id=42% cov=98%
--KTPLRVGSRASPLALAQARQFVYRLALRFPDAfpqaheiiqaslaklsnplpsssssdssssssaspsssssassssssspanshlassafssvlasllrvdsrleygELRIVPMQTTGDKELHLPLAQVGGKGLFTKELDLALLHGQVDVVVHSLKDVPTELPEGTEIGAYLPREDPRDALIFSRKPRrglsrackaqvpggvaetarrsatqqrvsaaasgapsvgssasaslLPYLPDALfasgglpeeteeagraarashteddaggvegearkgdegrpRIGTCSLRRQALLYALLPpsSFQLMGLRGNVQTRMSRIEKGTLDATLLAAAGLKRLNLlsamlapspsatpspcpapspneTSRGTEPggcveavlLPADVFVPAVCQGIIGVQCRSADTGILSLLRELNSPSSRGQALCERAFLRALDGSCRTPIAGIAEWRavpaqgeaprpqsqngsdepgveregeegcagssvkgregrseegwgghpdcftektelrfcgvlatpDGKqlLRFCGVLATPDGKQLFREERTVrgvrTPEEAEALGRAVAEEIKKAAGADRLAQIKK-----
>UniRef50_Q6MEK3(17-232:233) Putative Porphobilinogen deaminase n=2 Tax=Parachlamydiaceae RepID=Q6MEK3_PARUW  E=2e-57 s/c=1.04 id=32% cov=68%
-----ISVGARSSPLSRAQVQEILKALRSFYPSIEFTISYFDTIGDLDQKTSLRDLDKTNFFTKEIDEAILQKKCQIGIHSAKDLPDPIPDGLQLICLTKGVDCSDVLVLRDGETLQTLPPHSRIATSSIRRENIVKLLRNDFIFLDLRGTIHQRLALLEKKQADGVVVAEAALIRLGLTHLNRIRLPGTTV---EGQGQLAIIARKDDAKMQTLFACLD---------------------------------------------------------------------------------------------
>UniRef50_C5G109(93-280:282) Porphobilinogen deaminase n=1 Tax=Microsporum canis CBS 113480 RepID=C5G109_NANOT  E=2e-22 s/c=0.57 id=29% cov=59%
-----------------------------------------------------------------------------------DVSTKLPDSCDPAAIPVKA-------GLPYTSLQTLPEGAIIATSLVRPSAQLRRLFPTLRFANVRGNV--------------------------------ESLTIPQAL-----GTVGSSTRGRPRARRRRHQGYSSAGSADRLLALPSVLMcALRSGCNAPIGIETEWTATHLSIRAIVVSLDISQSVEDAIDAmmhTKDESDAPGQALA-RLFGAGVAPILIDI-NRNQPS
