BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (313 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_B7LU53 Porphobilinogen deaminase n=87 Tax=cellular orga...   593   e-168
UniRef50_B5FN93 Porphobilinogen deaminase n=168 Tax=cellular org...   566   e-160
UniRef50_Q0I178 Porphobilinogen deaminase n=45 Tax=Bacteria RepI...   387   e-106
UniRef50_C0QU69 Porphobilinogen deaminase n=4 Tax=Bacteria RepID...   365   1e-99
UniRef50_B5YJZ4 Porphobilinogen deaminase n=2 Tax=Bacteria RepID...   322   1e-86
UniRef50_A1AUE7 Porphobilinogen deaminase n=44 Tax=Bacteria RepI...   307   2e-82
UniRef50_B5EBG8 Porphobilinogen deaminase n=166 Tax=Bacteria Rep...   306   6e-82
UniRef50_Q30Y29 Porphobilinogen deaminase n=13 Tax=Bacteria RepI...   305   2e-81
UniRef50_A7GYU4 Porphobilinogen deaminase n=34 Tax=Campylobacter...   301   2e-80
UniRef50_Q5ZRY6 Porphobilinogen deaminase n=6 Tax=Legionella Rep...   296   7e-79
UniRef50_B3E2H7 Porphobilinogen deaminase n=3 Tax=Proteobacteria...   293   4e-78
UniRef50_C9KL85 Hydroxymethylbilane synthase n=1 Tax=Mitsuokella...   293   6e-78
UniRef50_C6HUG2 Porphobilinogen deaminase n=1 Tax=Leptospirillum...   292   1e-77
UniRef50_Q8YVU6 Porphobilinogen deaminase n=50 Tax=cellular orga...   291   3e-77
UniRef50_Q3ACT3 Porphobilinogen deaminase n=2 Tax=Bacteria RepID...   288   2e-76
UniRef50_D0LUE1 Porphobilinogen deaminase n=1 Tax=Haliangium och...   286   6e-76
UniRef50_Q8DIE4 Porphobilinogen deaminase n=11 Tax=cellular orga...   285   1e-75
UniRef50_D1BNZ5 Porphobilinogen deaminase n=3 Tax=Veillonella Re...   276   7e-73
UniRef50_A9FDP9 Porphobilinogen deaminase n=1 Tax=Sorangium cell...   276   8e-73
UniRef50_A7NKU8 Porphobilinogen deaminase n=5 Tax=Bacteria RepID...   275   1e-72
UniRef50_Q31PM2 Porphobilinogen deaminase n=8 Tax=cellular organ...   275   1e-72
UniRef50_Q4HT06 Porphobilinogen deaminase n=1 Tax=Campylobacter ...   275   2e-72
UniRef50_C0Q9U2 HemC n=2 Tax=Bacteria RepID=C0Q9U2_DESAH              275   2e-72
UniRef50_B3QWI1 Porphobilinogen deaminase n=12 Tax=Chlorobiaceae...   273   7e-72
UniRef50_A3MLK5 Porphobilinogen deaminase n=155 Tax=Proteobacter...   270   4e-71
UniRef50_Q8D2W2 HemC protein n=1 Tax=Wigglesworthia glossinidia ...   268   3e-70
UniRef50_A6TJD5 Porphobilinogen deaminase n=2 Tax=Firmicutes Rep...   264   3e-69
UniRef50_Q2RJ26 Porphobilinogen deaminase n=5 Tax=Clostridia Rep...   263   5e-69
UniRef50_A8PKX6 Porphobilinogen deaminase n=2 Tax=Gammaproteobac...   262   1e-68
UniRef50_D2R3S6 Porphobilinogen deaminase n=2 Tax=Planctomycetac...   258   2e-67
UniRef50_A3ETN3 Porphobilinogen deaminase n=2 Tax=Leptospirillum...   256   5e-67
UniRef50_C8WXM9 Porphobilinogen deaminase n=2 Tax=Alicyclobacill...   256   8e-67
UniRef50_A8LIJ6 Porphobilinogen deaminase n=11 Tax=Alphaproteoba...   254   2e-66
UniRef50_Q65GK1 Porphobilinogen deaminase n=98 Tax=Bacillales Re...   254   3e-66
UniRef50_A6Q7Y4 Porphobilinogen deaminase n=7 Tax=Epsilonproteob...   253   6e-66
UniRef50_C9R7U0 Porphobilinogen deaminase n=1 Tax=Ammonifex dege...   249   6e-65
UniRef50_B2A1G7 Porphobilinogen deaminase n=1 Tax=Natranaerobius...   249   6e-65
UniRef50_Q4L709 Porphobilinogen deaminase n=88 Tax=Bacillales Re...   249   1e-64
UniRef50_Q43316 Porphobilinogen deaminase, chloroplastic n=61 Ta...   248   2e-64
UniRef50_Q2S2A6 Porphobilinogen deaminase n=1 Tax=Salinibacter r...   248   2e-64
UniRef50_P08397 Porphobilinogen deaminase n=59 Tax=Chordata RepI...   244   2e-63
UniRef50_C3XEZ5 Porphobilinogen deaminase n=3 Tax=Campylobactera...   244   3e-63
UniRef50_Q2LQU2 Porphobilinogen deaminase n=1 Tax=Syntrophus aci...   244   4e-63
UniRef50_Q54P93 Porphobilinogen deaminase n=1 Tax=Dictyostelium ...   240   4e-62
UniRef50_B2S842 Porphobilinogen deaminase n=38 Tax=Rhizobiales R...   236   7e-61
UniRef50_A6WXJ2 Porphobilinogen deaminase n=56 Tax=cellular orga...   236   8e-61
UniRef50_A6GB01 Porphobilinogen deaminase n=2 Tax=Bacteria RepID...   231   3e-59
UniRef50_A3ZKX4 Porphobilinogen deaminase n=1 Tax=Blastopirellul...   231   4e-59
UniRef50_C8WIZ2 Porphobilinogen deaminase n=2 Tax=Coriobacteriac...   230   5e-59
UniRef50_UPI0000583C22 PREDICTED: hypothetical protein n=1 Tax=S...   229   1e-58
UniRef50_A7BMK1 Porphobilinogen deaminase n=1 Tax=Beggiatoa sp. ...   228   2e-58
UniRef50_C1ZK04 Porphobilinogen deaminase n=1 Tax=Planctomyces l...   228   2e-58
UniRef50_C1AA38 Porphobilinogen deaminase n=1 Tax=Gemmatimonas a...   227   4e-58
UniRef50_UPI00017922DC PREDICTED: similar to porphobilinogen dea...   225   1e-57
UniRef50_Q1J288 Porphobilinogen deaminase n=5 Tax=Deinococci Rep...   224   4e-57
UniRef50_A8U3E9 Porphobilinogen deaminase n=1 Tax=alpha proteoba...   222   1e-56
UniRef50_A6DBT5 Porphobilinogen deaminase n=1 Tax=Caminibacter m...   222   1e-56
UniRef50_A3CL78 Porphobilinogen deaminase n=1 Tax=Streptococcus ...   219   7e-56
UniRef50_C1F251 Hydroxymethylbilane synthase n=1 Tax=Acidobacter...   219   7e-56
UniRef50_O94048 Porphobilinogen deaminase n=53 Tax=Saccharomycet...   217   5e-55
UniRef50_C7NFP7 Hydroxymethylbilane synthase n=7 Tax=Actinomycet...   215   1e-54
UniRef50_Q0TQG4 Porphobilinogen deaminase n=32 Tax=Clostridium R...   214   3e-54
UniRef50_Q3YSA8 Porphobilinogen deaminase n=17 Tax=Rickettsiales...   214   4e-54
UniRef50_B6FXV9 Putative uncharacterized protein n=1 Tax=Clostri...   212   1e-53
UniRef50_C3PNS9 Porphobilinogen deaminase n=15 Tax=Rickettsia Re...   212   1e-53
UniRef50_Q180R9 Porphobilinogen deaminase n=11 Tax=Bacteria RepI...   212   1e-53
UniRef50_A3VPD5 Porphobilinogen deaminase n=1 Tax=Parvularcula b...   211   2e-53
UniRef50_Q5HBG1 Porphobilinogen deaminase n=2 Tax=Ehrlichia rumi...   211   2e-53
UniRef50_B3U3W9 Hydroxymethylbilane synthetase n=1 Tax=Oxyrrhis ...   209   7e-53
UniRef50_A8MDU3 Probable porphobilinogen deaminase n=2 Tax=Therm...   209   7e-53
UniRef50_C4Z552 Porphobilinogen deaminase n=8 Tax=Bacteria RepID...   209   1e-52
UniRef50_A5CDH4 Porphobilinogen deaminase n=2 Tax=Orientia tsuts...   208   2e-52
UniRef50_Q1EPC8 Porphobilinogen deaminase, chloroplast (Hydroxym...   207   5e-52
UniRef50_C1CYD9 Porphobilinogen deaminase n=3 Tax=Deinococci Rep...   207   5e-52
UniRef50_B8GXG1 Porphobilinogen deaminase n=8 Tax=Caulobacterace...   205   1e-51
UniRef50_Q8TXC8 Probable porphobilinogen deaminase n=1 Tax=Metha...   205   1e-51
UniRef50_B2IAW6 Porphobilinogen deaminase n=4 Tax=Alphaproteobac...   205   1e-51
UniRef50_Q11XT5 Porphobilinogen deaminase n=8 Tax=Bacteria RepID...   204   3e-51
UniRef50_A2BL26 Probable porphobilinogen deaminase n=2 Tax=Therm...   204   4e-51
UniRef50_B3T8H9 Putative Porphobilinogen deaminase, dipyromethan...   204   4e-51
UniRef50_B0K2L4 Porphobilinogen deaminase n=7 Tax=Bacteria RepID...   204   4e-51
UniRef50_A0QLI0 Porphobilinogen deaminase n=69 Tax=Actinomycetal...   204   4e-51
UniRef50_D1CBT4 Porphobilinogen deaminase n=1 Tax=Thermobaculum ...   202   1e-50
UniRef50_A6GVP0 Hydroxymethylbilane synthase n=18 Tax=Bacteroide...   202   1e-50
UniRef50_A0LRF1 Porphobilinogen deaminase n=1 Tax=Acidothermus c...   201   2e-50
UniRef50_A9A1A1 Probable porphobilinogen deaminase n=3 Tax=Thaum...   201   2e-50
UniRef50_C6WZF5 Porphobilinogen deaminase n=1 Tax=Flavobacteriac...   201   3e-50
UniRef50_Q1V167 Hydroxymethylbilane synthase n=3 Tax=Candidatus ...   201   3e-50
UniRef50_A2Q9P7 Catalytic activity: 4 porphobilinogen+H(2)O<=>hy...   201   4e-50
UniRef50_Q9F7M2 Predicted porphobilinogen deaminase n=2 Tax=Bact...   200   4e-50
UniRef50_C7N5L0 Porphobilinogen deaminase n=2 Tax=Slackia RepID=...   200   5e-50
UniRef50_Q0BX92 Porphobilinogen deaminase n=1 Tax=Hyphomonas nep...   199   8e-50
UniRef50_A5VM67 Porphobilinogen deaminase n=9 Tax=Lactobacillus ...   199   8e-50
UniRef50_Q47LA7 Porphobilinogen deaminase n=3 Tax=Actinomycetale...   199   9e-50
UniRef50_C0YV01 Hydroxymethylbilane synthase n=1 Tax=Chryseobact...   199   1e-49
UniRef50_D0NJW2 Porphobilinogen deaminase n=2 Tax=Phytophthora i...   199   1e-49
UniRef50_Q82P95 Porphobilinogen deaminase 2 n=14 Tax=Actinomycet...   199   1e-49
UniRef50_C6R3Y0 Hydroxymethylbilane synthase n=1 Tax=Rothia muci...   198   2e-49
UniRef50_Q8RFP5 Porphobilinogen deaminase n=16 Tax=Fusobacteriac...   198   2e-49
UniRef50_C9RPT6 Porphobilinogen deaminase n=1 Tax=Fibrobacter su...   198   3e-49
UniRef50_A4CHM3 Porphobilinogen deaminase n=4 Tax=Bacteroidetes ...   197   3e-49
UniRef50_D2NS36 Porphobilinogen deaminase n=2 Tax=Micrococcaceae...   197   4e-49
UniRef50_Q7UPN0 Porphobilinogen deaminase n=1 Tax=Rhodopirellula...   197   4e-49
UniRef50_B5G8F1 Porphobilinogen deaminase n=1 Tax=Streptomyces s...   196   8e-49
UniRef50_C6XGK7 Porphobilinogen deaminase n=1 Tax=Candidatus Lib...   196   9e-49
UniRef50_UPI0001926E0E PREDICTED: similar to hydroxymethylbilane...   196   1e-48
UniRef50_C3WGN0 Porphobilinogen deaminase n=5 Tax=Fusobacterium ...   196   1e-48
UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia...   195   1e-48
UniRef50_C6XST0 Porphobilinogen deaminase n=2 Tax=Pedobacter Rep...   194   3e-48
UniRef50_C5RMN3 Porphobilinogen deaminase n=1 Tax=Clostridium ce...   194   3e-48
UniRef50_P28789 Porphobilinogen deaminase n=18 Tax=Saccharomycet...   194   3e-48
UniRef50_Q09899 Porphobilinogen deaminase n=2 Tax=Schizosaccharo...   192   1e-47
UniRef50_A0DD68 Chromosome undetermined scaffold_46, whole genom...   192   2e-47
UniRef50_A8MGE4 Porphobilinogen deaminase n=30 Tax=cellular orga...   191   3e-47
UniRef50_C0BZ93 Putative uncharacterized protein n=1 Tax=Clostri...   191   3e-47
UniRef50_Q1AUK3 Porphobilinogen deaminase n=1 Tax=Rubrobacter xy...   191   3e-47
UniRef50_C1TM53 Porphobilinogen deaminase n=1 Tax=Dethiosulfovib...   191   3e-47
UniRef50_B3RTQ8 Putative uncharacterized protein n=1 Tax=Trichop...   191   4e-47
UniRef50_B0D5Q2 Predicted protein n=1 Tax=Laccaria bicolor S238N...   190   5e-47
UniRef50_C4QMG7 Hydroxymethylbilane synthase (Porphobilinogen de...   189   1e-46
UniRef50_D1BFI8 Hydroxymethylbilane synthase n=4 Tax=Actinomycet...   189   1e-46
UniRef50_Q4T5L1 Chromosome undetermined SCAF9206, whole genome s...   189   1e-46
UniRef50_UPI00006CBE06 porphobilinogen deaminase family protein ...   188   2e-46
UniRef50_B8MVK7 Porphobilinogen deaminase, putative n=1 Tax=Tala...   187   4e-46
UniRef50_B9XN63 Porphobilinogen deaminase n=1 Tax=bacterium Elli...   187   4e-46
UniRef50_C4ZFT9 Porphobilinogen deaminase n=1 Tax=Eubacterium re...   186   8e-46
UniRef50_Q0ATQ1 Porphobilinogen deaminase n=3 Tax=Alphaproteobac...   186   1e-45
UniRef50_Q4PFH9 Putative uncharacterized protein n=1 Tax=Ustilag...   186   1e-45
UniRef50_C9M5W1 Hydroxymethylbilane synthase n=1 Tax=Jonquetella...   186   1e-45
UniRef50_C5EV71 Pyruvate ferredoxin/flavodoxin oxidoreductase n=...   185   2e-45
UniRef50_Q93A65 Porphobilinogen deaminase n=1 Tax=uncultured bac...   185   2e-45
UniRef50_A8PWJ5 Putative uncharacterized protein n=1 Tax=Malasse...   185   2e-45
UniRef50_Q6L2G8 Probable porphobilinogen deaminase n=1 Tax=Picro...   185   2e-45
UniRef50_A2BFN7 Hydroxymethylbilane synthase (Fragment) n=6 Tax=...   185   2e-45
UniRef50_O29026 Probable porphobilinogen deaminase n=1 Tax=Archa...   184   3e-45
UniRef50_B2W5W6 Porphobilinogen deaminase n=2 Tax=Pleosporineae ...   184   4e-45
UniRef50_A9HK97 Porphobilinogen deaminase n=12 Tax=Acetobacterac...   183   8e-45
UniRef50_C1XV35 Porphobilinogen deaminase n=2 Tax=Meiothermus Re...   182   2e-44
UniRef50_A4QB59 Porphobilinogen deaminase n=15 Tax=Corynebacteri...   181   3e-44
UniRef50_C6V4N6 Porphobilinogen deaminase n=2 Tax=Neorickettsia ...   181   4e-44
UniRef50_A8SQW4 Putative uncharacterized protein n=1 Tax=Coproco...   180   6e-44
UniRef50_C7M2H5 Porphobilinogen deaminase n=1 Tax=Acidimicrobium...   179   8e-44
UniRef50_B3DZQ6 Porphobilinogen deaminase n=1 Tax=Methylacidiphi...   179   1e-43
UniRef50_C5CB88 Porphobilinogen deaminase n=5 Tax=Actinomycetale...   179   1e-43
UniRef50_C7DH16 Porphobilinogen deaminase n=1 Tax=Candidatus Mic...   179   1e-43
UniRef50_D2RH82 Porphobilinogen deaminase n=2 Tax=Archaeoglobace...   179   1e-43
UniRef50_B4D5X7 Porphobilinogen deaminase n=1 Tax=Chthoniobacter...   179   2e-43
UniRef50_UPI000174444E Hydroxymethylbilane synthase n=1 Tax=Verr...   176   1e-42
UniRef50_Q1GP41 Porphobilinogen deaminase n=7 Tax=Sphingomonadal...   176   1e-42
UniRef50_UPI0001BC2D4C glutamyl-tRNA reductase n=1 Tax=Brevibact...   176   1e-42
UniRef50_A4XK06 Porphobilinogen deaminase n=2 Tax=Clostridia Rep...   175   2e-42
UniRef50_C6XKH7 Porphobilinogen deaminase n=1 Tax=Hirschia balti...   175   2e-42
UniRef50_C7R376 Porphobilinogen deaminase n=1 Tax=Jonesia denitr...   174   3e-42
UniRef50_D2RNT2 Porphobilinogen deaminase n=1 Tax=Acidaminococcu...   174   3e-42
UniRef50_Q46CH0 Probable porphobilinogen deaminase n=7 Tax=Eurya...   174   4e-42
UniRef50_C2GGB5 Porphobilinogen deaminase n=2 Tax=Corynebacteriu...   172   1e-41
UniRef50_C8WDJ7 Porphobilinogen deaminase n=3 Tax=Zymomonas mobi...   172   2e-41
UniRef50_C2FZW8 Porphobilinogen deaminase n=2 Tax=Sphingobacteri...   170   6e-41
UniRef50_A8AAB4 Probable porphobilinogen deaminase n=1 Tax=Ignic...   169   1e-40
UniRef50_D1VCA1 Porphobilinogen deaminase n=1 Tax=Frankia sp. Eu...   169   1e-40
UniRef50_UPI0001C31A39 porphobilinogen deaminase n=1 Tax=Conexib...   169   1e-40
UniRef50_A9V9E0 Predicted protein n=1 Tax=Monosiga brevicollis R...   168   2e-40
UniRef50_B5JN62 Porphobilinogen deaminase n=1 Tax=Verrucomicrobi...   168   2e-40
UniRef50_D1C4S0 Porphobilinogen deaminase n=1 Tax=Sphaerobacter ...   167   5e-40
UniRef50_B6W7F3 Putative uncharacterized protein n=1 Tax=Anaeroc...   167   5e-40
UniRef50_Q6AHF1 Porphobilinogen deaminase n=5 Tax=Actinobacteria...   166   8e-40
UniRef50_C5C5B3 Porphobilinogen deaminase n=6 Tax=Actinomycetale...   166   1e-39
UniRef50_A6LKX0 Porphobilinogen deaminase n=1 Tax=Thermosipho me...   164   4e-39
UniRef50_Q5KKQ0 Hydroxymethylbilane synthase, putative n=2 Tax=F...   164   4e-39
UniRef50_A4WN24 Probable porphobilinogen deaminase n=3 Tax=Therm...   164   5e-39
UniRef50_B2ULP1 Porphobilinogen deaminase n=1 Tax=Akkermansia mu...   163   6e-39
UniRef50_B0WMK9 Porphobilinogen deaminase n=1 Tax=Culex quinquef...   162   1e-38
UniRef50_B3LB83 Porphobilinogen deaminase, putative n=1 Tax=Plas...   162   1e-38
UniRef50_Q57989 Probable porphobilinogen deaminase n=11 Tax=Meth...   159   1e-37
UniRef50_Q2FTK7 Hydroxymethylbilane synthase n=3 Tax=Methanomicr...   158   2e-37
UniRef50_O26960 Probable porphobilinogen deaminase n=1 Tax=Metha...   158   3e-37
UniRef50_A4YD92 Probable porphobilinogen deaminase n=1 Tax=Metal...   158   3e-37
UniRef50_A1DGB8 Porphobilinogen deaminase n=1 Tax=Neosartorya fi...   156   8e-37
UniRef50_D1B7N1 Porphobilinogen deaminase n=1 Tax=Thermanaerovib...   156   8e-37
UniRef50_A2SQU4 Uroporphyrin-III C-methyltransferase n=11 Tax=Eu...   154   3e-36
UniRef50_Q8I5V3 Porphobilinogen deaminase n=6 Tax=Plasmodium Rep...   154   3e-36
UniRef50_Q2NEP4 HemC n=4 Tax=Methanobacteriaceae RepID=Q2NEP4_METST   153   7e-36
UniRef50_D0J8N1 Porphobilinogen deaminase n=2 Tax=Blattabacteriu...   153   8e-36
UniRef50_B5GJG2 Porphobilinogen deaminase n=3 Tax=Streptomyces R...   153   9e-36
UniRef50_C0W553 Porphobilinogen deaminase n=2 Tax=Actinomycetale...   151   3e-35
UniRef50_C4JRY9 Porphobilinogen deaminase n=1 Tax=Uncinocarpus r...   151   4e-35
UniRef50_B6JII8 Porphobilinogen deaminase n=11 Tax=Bradyrhizobia...   150   6e-35
UniRef50_D1JID7 Porphobilinogen deaminase n=1 Tax=uncultured arc...   149   1e-34
UniRef50_A5K0J5 Porphobilinogen deaminase, putative n=1 Tax=Plas...   148   3e-34
UniRef50_Q4E9D5 Porphobilinogen deaminase (Fragment) n=1 Tax=Wol...   147   6e-34
UniRef50_C3MZR8 Probable porphobilinogen deaminase n=11 Tax=Sulf...   145   2e-33
UniRef50_UPI000038E213 porphobilinogen deaminase n=1 Tax=Ferropl...   142   1e-32
UniRef50_Q9Y9J0 Probable porphobilinogen deaminase n=1 Tax=Aerop...   142   2e-32
UniRef50_Q86ET2 Clone ZZD1450 mRNA sequence n=3 Tax=Schistosoma ...   137   4e-31
UniRef50_Q97B26 Probable porphobilinogen deaminase n=2 Tax=Therm...   135   2e-30
UniRef50_Q0RS16 Porphobilinogen deaminase 1 (PBG 1) (Hydroxymeth...   133   8e-30
UniRef50_Q83H95 Porphobilinogen deaminase n=2 Tax=Tropheryma whi...   131   3e-29
UniRef50_B6YQR9 Hydroxymethylbilane synthase/uroporphyrin-III C-...   130   4e-29
UniRef50_B4UXX3 Porphobilinogen deaminase 2 (Fragment) n=1 Tax=S...   130   9e-29
UniRef50_B1ZV87 Porphobilinogen deaminase n=2 Tax=Opitutaceae Re...   129   9e-29
UniRef50_Q04X38 Bifunctional porphobilinogen deaminase/uroporphy...   129   2e-28
UniRef50_Q9HMY5 Probable porphobilinogen deaminase n=2 Tax=Halob...   127   6e-28
UniRef50_A8I2X7 Porphobilinogen deaminase n=1 Tax=Chlamydomonas ...   118   3e-25
UniRef50_Q18ES3 Hydroxymethylbilane synthase (Porphobilinogen de...   114   3e-24
UniRef50_Q9PK95 Probable porphobilinogen deaminase n=13 Tax=Chla...   114   4e-24
UniRef50_B0SF66 Bifunctional porphobilinogen deaminase/uroporphy...   112   2e-23
UniRef50_Q6MEK3 Putative Porphobilinogen deaminase n=2 Tax=Parac...   111   4e-23
UniRef50_UPI0001B4213A porphobilinogen deaminase n=1 Tax=Listeri...   106   1e-21
UniRef50_UPI000155526F PREDICTED: similar to hydroxymethylbilane...   104   3e-21
UniRef50_UPI0001698669 porphobilinogen deaminase n=1 Tax=Endorif...   101   3e-20
UniRef50_C0EAN0 Putative uncharacterized protein n=1 Tax=Clostri...   100   1e-19
UniRef50_Q6MHU0 Hydroxymethylbilane synthase n=1 Tax=Bdellovibri...    96   1e-18
UniRef50_Q6Q923 Predicted porphobilinogen deaminase n=2 Tax=envi...    95   3e-18
UniRef50_C0DZX9 Putative uncharacterized protein n=1 Tax=Coryneb...    94   7e-18
UniRef50_D0RNS6 Putative porphobilinogen deaminase (Pbg)(Hydroxy...    89   3e-16
UniRef50_A8CBG6 Porphobilinogen deaminase n=3 Tax=Toxoplasma gon...    89   3e-16
UniRef50_C5LJF7 Porphobilinogen deaminase, putative n=5 Tax=Perk...    79   1e-13
UniRef50_Q401C3 Hydroxymethylbilane synthase (Fragment) n=7 Tax=...    79   2e-13
UniRef50_B0KCR7 Porphobilinogen deaminase n=3 Tax=Thermoanaeroba...    76   2e-12
UniRef50_UPI0001742E92 Porphobilinogen deaminase n=1 Tax=candida...    63   2e-08
UniRef50_Q1HRH6 Hydroxymethylbilane synthase-like protein n=1 Ta...    59   2e-07
UniRef50_B8N6H4 Putative uncharacterized protein n=1 Tax=Aspergi...    48   3e-04
UniRef50_UPI0000D9FBB5 PREDICTED: similar to lethal (3) 02640 CG...    43   0.016

>UniRef50_B7LU53 Porphobilinogen deaminase n=87 Tax=cellular organisms
           RepID=HEM3_ESCF3
          Length = 313

 Score =  593 bits (1528), Expect = e-168,   Method: Compositional matrix adjust.
 Identities = 296/312 (94%), Positives = 302/312 (96%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           MLDNVLRIATRQSPLALWQAHYVKD LMA HPGL VELVPMVTRGDVILDTPLAKVGGKG
Sbjct: 1   MLDNVLRIATRQSPLALWQAHYVKDALMAKHPGLTVELVPMVTRGDVILDTPLAKVGGKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN Y SLD LP
Sbjct: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNKYASLDELP 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
           AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE
Sbjct: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
           SRIR ALPPE+SLPAVGQGAVGIECRLDD+RTRELLAALNH ETALRVTAERAMNTRLEG
Sbjct: 181 SRIRDALPPEVSLPAVGQGAVGIECRLDDTRTRELLAALNHPETALRVTAERAMNTRLEG 240

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           GCQVPIGSYAELI GEIWLRALVGAPDGSQ+IRGERRG+PQDAE+MGISLAEELLNNGAR
Sbjct: 241 GCQVPIGSYAELIGGEIWLRALVGAPDGSQMIRGERRGSPQDAEKMGISLAEELLNNGAR 300

Query: 301 EILAEVYNGDAP 312
            ILA+VYNGDAP
Sbjct: 301 AILADVYNGDAP 312


>UniRef50_B5FN93 Porphobilinogen deaminase n=168 Tax=cellular organisms
           RepID=HEM3_SALDC
          Length = 313

 Score =  566 bits (1459), Expect = e-160,   Method: Compositional matrix adjust.
 Identities = 279/313 (89%), Positives = 294/313 (93%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           MLDNVLRIATRQSPLALWQAHYVKD LMA+HPGL VELVPMVTRGDVILDTPLAKVGGKG
Sbjct: 1   MLDNVLRIATRQSPLALWQAHYVKDALMATHPGLTVELVPMVTRGDVILDTPLAKVGGKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKELE+ALLE RADIAVHSMKDVPV FP GLGLVTICEREDPRDAFVSN Y SLD LP
Sbjct: 61  LFVKELEIALLEKRADIAVHSMKDVPVAFPDGLGLVTICEREDPRDAFVSNKYHSLDDLP 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
           AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRL KLDNG+YDAIILAVAGLKRLGLE
Sbjct: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLGKLDNGDYDAIILAVAGLKRLGLE 180

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
           SRIR ALPP++SLPAVGQGAVGIECRLDD+RT+ LLA LNH +TALRVTAERAMNTRLEG
Sbjct: 181 SRIRTALPPDVSLPAVGQGAVGIECRLDDARTQALLAPLNHSQTALRVTAERAMNTRLEG 240

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           GCQVPIGSYAE+I+GEIWLRALVGAPDGS ++RGERRG+P+ AEQMGISLAEELL NGAR
Sbjct: 241 GCQVPIGSYAEIINGEIWLRALVGAPDGSVMVRGERRGSPEQAEQMGISLAEELLENGAR 300

Query: 301 EILAEVYNGDAPA 313
            IL EVYNG+ PA
Sbjct: 301 AILTEVYNGETPA 313


>UniRef50_Q0I178 Porphobilinogen deaminase n=45 Tax=Bacteria RepID=HEM3_HAES1
          Length = 321

 Score =  387 bits (993), Expect = e-106,   Method: Compositional matrix adjust.
 Identities = 199/318 (62%), Positives = 236/318 (74%), Gaps = 11/318 (3%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           ++  L+IATRQSPLALWQA+YVK++L   +  L VELVP++T+GDVILDTPLAK+GGKGL
Sbjct: 3   INKTLKIATRQSPLALWQANYVKNRLQQRYSHLSVELVPIITKGDVILDTPLAKIGGKGL 62

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FVKELE ALL   ADIAVHSMKDVP++FP+GL L  IC REDPRDAFVSN Y +LD LP 
Sbjct: 63  FVKELENALLNGEADIAVHSMKDVPMQFPKGLELSVICPREDPRDAFVSNKYRTLDELPQ 122

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+IVGTSSLRRQCQL   R DL IRSLRGNVGTRL+KLD G+YDAIILA AGL RLGL  
Sbjct: 123 GAIVGTSSLRRQCQLKNWRADLDIRSLRGNVGTRLNKLDQGDYDAIILASAGLIRLGLTE 182

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
           RIR+ +  +  LPA GQGAVGIECR+DD   + LL  L    T   V AERAMN  L+GG
Sbjct: 183 RIRSFIEIDTILPACGQGAVGIECRVDDRDVQSLLMPLADQTTTYCVLAERAMNFHLQGG 242

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE-----------RRGAPQDAEQMGISL 290
           CQVPIG+YA L + +++LR LVG   GSQI+  E            + A Q AE++G+S+
Sbjct: 243 CQVPIGAYAILENNQLYLRGLVGDVHGSQILSAEGQFELSLDFESSQSAVQKAEELGVSI 302

Query: 291 AEELLNNGAREILAEVYN 308
           AE+LL  GA +IL  VY 
Sbjct: 303 AEQLLQQGADKILQAVYQ 320


>UniRef50_C0QU69 Porphobilinogen deaminase n=4 Tax=Bacteria RepID=C0QU69_PERMH
          Length = 308

 Score =  365 bits (937), Expect = 1e-99,   Method: Compositional matrix adjust.
 Identities = 171/304 (56%), Positives = 229/304 (75%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR+S LALWQA+Y+ D+L    P L VELV +VT+GD ILD PLAKVGGKGLFVKE
Sbjct: 3   IRIGTRKSKLALWQANYIADQLKKHFPDLEVELVKIVTKGDKILDVPLAKVGGKGLFVKE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E A+L N  DIAVHS+KDVP  FP+GLGLV I EREDPRDAF+S  Y+S++ +P G+++
Sbjct: 63  IEEAMLRNEIDIAVHSLKDVPTYFPEGLGLVAITEREDPRDAFLSVKYNSIEDMPEGAVL 122

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSSLRR+ Q+  +R D+ I  LRGNV TR+ KL+ G+YD IILA AGLKRLGLE ++R 
Sbjct: 123 GTSSLRRKAQIMMKRKDIRIEDLRGNVDTRIRKLEEGQYDGIILAYAGLKRLGLEGKVRQ 182

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L P+  +PAV QG +GIE RLDD +TRE+++ LNH E+ +R  AERA    LEGGCQVP
Sbjct: 183 ILQPDYMIPAVAQGFLGIEARLDDEKTREIVSVLNHRESEIRAKAERAFLKTLEGGCQVP 242

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305
           +  Y+E+++G++ +   V    G ++ R    G+ +DAE +G+ LAE+LL++GA+E+L E
Sbjct: 243 LAGYSEIVNGKLKITGFVSDLTGDRVFRDSMEGSLEDAESLGVKLAEKLLSDGAKEVLEE 302

Query: 306 VYNG 309
           +Y+G
Sbjct: 303 IYSG 306


>UniRef50_B5YJZ4 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=B5YJZ4_THEYD
          Length = 311

 Score =  322 bits (825), Expect = 1e-86,   Method: Compositional matrix adjust.
 Identities = 157/306 (51%), Positives = 218/306 (71%), Gaps = 1/306 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           N + I +R S LA+WQA++VKDKL   +P L VE+  + T GD ILD PLAK+GGKGLFV
Sbjct: 6   NKIVIGSRGSKLAMWQANWVKDKLQTLYPELKVEIEKIKTTGDKILDAPLAKIGGKGLFV 65

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KE+E ALL  R D+AVHSMKDVP E P+GL +  ICEREDPRDAF+S +   L+ LP  +
Sbjct: 66  KEIEEALLSKRVDLAVHSMKDVPTEIPEGLQISAICEREDPRDAFISKDGVLLNELPQEA 125

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           ++GTSSLRR  QL   R DL+I+ LRGNV TR+ KL +GE+ AI+LA+AG+KR+G+E+ +
Sbjct: 126 VLGTSSLRRTVQLKALRNDLVIKPLRGNVDTRIRKLKDGEFQAIVLAMAGVKRMGVENLV 185

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
             A   ++ +PA+GQGA+GIE R+DD    EL+  LNH ETA+ + AERA  + + GGCQ
Sbjct: 186 TQAFSEDLMIPAIGQGAIGIETRVDDDFVNELIKPLNHEETAICILAERAFLSVMGGGCQ 245

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQ-IIRGERRGAPQDAEQMGISLAEELLNNGAREI 302
           VP+  +A +++  + +  ++G P+G   +I+G R G+   A+ +G+ LA ELL+ G +EI
Sbjct: 246 VPLACHARIVNNSLKIVGMIGDPEGKMPVIKGFREGSLSQAQSLGVELANELLHRGGKEI 305

Query: 303 LAEVYN 308
           L +VY 
Sbjct: 306 LEKVYK 311


>UniRef50_A1AUE7 Porphobilinogen deaminase n=44 Tax=Bacteria RepID=HEM3_PELPD
          Length = 310

 Score =  307 bits (787), Expect = 2e-82,   Method: Compositional matrix adjust.
 Identities = 166/303 (54%), Positives = 202/303 (66%), Gaps = 1/303 (0%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LRI TR S LALWQA++VK +L   +P + V L  + T GD ILD PLA+VGGKGLFVKE
Sbjct: 6   LRIGTRASQLALWQANWVKSELEKRYPAMEVTLTKIKTMGDRILDVPLAQVGGKGLFVKE 65

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E A+L    DIAVHSMKDVP EFP+GLGL  I EREDPRDA VS        LP G+ V
Sbjct: 66  IEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVVSRAA-RFSHLPPGARV 124

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTS+LRRQ QL   RPDL + ++RGNV TR+ KLD    DA+ILA AGLKRLGL  R+  
Sbjct: 125 GTSALRRQAQLLHARPDLEMVTIRGNVETRIRKLDEENLDAVILAAAGLKRLGLTQRVAE 184

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L  E S+PA+GQGA+GIECRL D    E +A  NH +T+  V AERA+  R +GGCQVP
Sbjct: 185 YLDVEFSIPAIGQGALGIECRLSDPVVTEAIAFFNHPDTSHAVRAERALLRRCQGGCQVP 244

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305
           I ++  +  GE+ L  L+ A DG + +R E  G     E +G  LA+ LL+ G R IL E
Sbjct: 245 IAAHGTIRGGELRLVGLIAAVDGREFVRDEISGPVDQCEHLGEELADRLLSRGGRAILEE 304

Query: 306 VYN 308
           VY 
Sbjct: 305 VYQ 307


>UniRef50_B5EBG8 Porphobilinogen deaminase n=166 Tax=Bacteria RepID=HEM3_GEOBB
          Length = 318

 Score =  306 bits (784), Expect = 6e-82,   Method: Compositional matrix adjust.
 Identities = 158/303 (52%), Positives = 204/303 (67%), Gaps = 1/303 (0%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LRI TR S LALWQA++VK +L   +P + V L  + T GD ILD PLA+VGGKGLFVKE
Sbjct: 6   LRIGTRASQLALWQANWVKSELEKRYPDMTVTLTKIKTIGDKILDVPLAQVGGKGLFVKE 65

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E A+L    DIAVHSMKDVP EFP+GLGL  I EREDPRDA +SN     D LP G+ +
Sbjct: 66  IEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVISNGVKFAD-LPQGARI 124

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTS+LRRQ QL + RPDL +  +RGNV TR+ KL     DA+ILA AGL RLG   +I  
Sbjct: 125 GTSALRRQAQLLKVRPDLEMVIIRGNVQTRMDKLKTEGLDAVILAAAGLNRLGFADQITE 184

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            LP ++SLPA+GQGA+GIEC L +   ++ ++  N  +T+  V AERA+  R EGGCQVP
Sbjct: 185 MLPTDLSLPAIGQGALGIECNLSNQDVKDAISFFNSPDTSRAVRAERALLWRCEGGCQVP 244

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305
           I ++ E+   ++ L   + + DG   ++G   G   D E++G+ LAE+LL+ G   ILAE
Sbjct: 245 IAAFGEVTGDQLKLTGFIASVDGKVSVKGVVTGPADDCEKLGVKLAEQLLSEGGHAILAE 304

Query: 306 VYN 308
           VY 
Sbjct: 305 VYQ 307


>UniRef50_Q30Y29 Porphobilinogen deaminase n=13 Tax=Bacteria RepID=HEM3_DESDG
          Length = 316

 Score =  305 bits (780), Expect = 2e-81,   Method: Compositional matrix adjust.
 Identities = 167/307 (54%), Positives = 209/307 (68%), Gaps = 3/307 (0%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHP-GLVVELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66
           IATR S LALWQA ++K+++M  +P    VEL+ + T+GD+ILD PLAKVGGKGLFVKE+
Sbjct: 6   IATRGSKLALWQAEHIKERIMQQYPDSFEVELLVLKTKGDIILDVPLAKVGGKGLFVKEI 65

Query: 67  EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126
           E ALL+ RADIAVHSMKDVP+E PQGL L  I ERE P D+ +S  YD LDALP G++VG
Sbjct: 66  EEALLDGRADIAVHSMKDVPMELPQGLTLGAIPEREVPTDSLLSARYDGLDALPQGAVVG 125

Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAA 186
           TSSLRRQ Q+   RPDL ++ LRGNV TR+ KL +GEYDAII+A +GLKRLG  +   + 
Sbjct: 126 TSSLRRQSQILAMRPDLEVKWLRGNVQTRIRKLMDGEYDAIIMATSGLKRLGETAPFHSE 185

Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246
           L P + +PAVGQGA+G+E R D     E+LA L+H  + + V AER     L+GGCQVPI
Sbjct: 186 LGPPLFMPAVGQGALGLEYRSDRQDLAEMLAFLDHRPSRICVEAERGFLFGLQGGCQVPI 245

Query: 247 GSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305
             YA +  D    L  LV   DG+ +IR    G   DA   G++LA ++   GA  IL  
Sbjct: 246 AGYAVMTGDNSFELTGLVAELDGTAVIRRTAAGTEADARDTGLTLAAQVKAAGADAILQR 305

Query: 306 VY-NGDA 311
           VY NG A
Sbjct: 306 VYENGHA 312


>UniRef50_A7GYU4 Porphobilinogen deaminase n=34 Tax=Campylobacterales
           RepID=HEM3_CAMC5
          Length = 311

 Score =  301 bits (771), Expect = 2e-80,   Method: Compositional matrix adjust.
 Identities = 160/302 (52%), Positives = 201/302 (66%), Gaps = 3/302 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
            +L+IATR+S LALWQ+ ++K +LMA H GL VELV M T+GDVILDTPLAK+GGKGLF 
Sbjct: 2   KILKIATRKSALALWQSEHIKARLMAQHAGLQVELVGMKTKGDVILDTPLAKIGGKGLFT 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KELE ++L  +  IAVHS+KDVPV F  GL L  IC RED RDA +S  Y   D LP  +
Sbjct: 62  KELEDSMLSGQTHIAVHSLKDVPVAFLDGLVLAAICSREDVRDAMISQRYVKFDDLPQSA 121

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            VGT+SLRR+ QL   RPDL I SLRGNV TRL KL  GE+DAIILA+AG+ RL L   +
Sbjct: 122 KVGTTSLRRKMQLLRMRPDLNIISLRGNVQTRLRKLKEGEFDAIILAMAGINRLNLADEV 181

Query: 184 RAALPPEIS--LPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
               P +I+   PA+GQGA+G+E  +DD++  E +  LN   + +    ER   T LEGG
Sbjct: 182 AHIYPFDIAQMTPAMGQGALGVEA-VDDAQILEKIKFLNDERSVIETRVERDFVTLLEGG 240

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           CQVPIG  A L   EI + A+VG PDGS++I         + E +G  LA E +  GA+E
Sbjct: 241 CQVPIGINARLASEEIEINAIVGLPDGSEVITENLTAKKSEFESVGKELAREFIARGAKE 300

Query: 302 IL 303
           +L
Sbjct: 301 LL 302


>UniRef50_Q5ZRY6 Porphobilinogen deaminase n=6 Tax=Legionella RepID=HEM3_LEGPH
          Length = 309

 Score =  296 bits (757), Expect = 7e-79,   Method: Compositional matrix adjust.
 Identities = 153/307 (49%), Positives = 204/307 (66%), Gaps = 1/307 (0%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M   ++RIATRQSPLALWQA++V++ L+   P L +EL+PM+T GD  L   L   GGKG
Sbjct: 1   MSAKIIRIATRQSPLALWQANHVREMLVKQWPNLSIELLPMITSGDRFLKDKLLSAGGKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKELE ALL+ RAD+AVHS KD+P + P GL L  IC+R++P DA +S  + SL ALP
Sbjct: 61  LFVKELEEALLDKRADLAVHSTKDMPAQLPDGLLLTAICKRDNPFDALISPQFKSLAALP 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
             +I+GTSSLRRQ QL    P+L I++LRGN+ TRLSKL++GEY AIILA AGL+R+GL 
Sbjct: 121 KNAIIGTSSLRRQSQLLAYNPNLQIKTLRGNIHTRLSKLESGEYQAIILAAAGLERMGLA 180

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
             I   +P +I LP   QGA+ IECR DD   +EL+  LN   +AL V  ER +N +L G
Sbjct: 181 HHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELVHGLNDPISALCVHTERRVNAKLGG 240

Query: 241 GCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
            C +P   Y  + + + + LRA V   DGSQ+I  E++G   +AE +     E L+  GA
Sbjct: 241 NCHIPFAVYCTITEEKLLLLRAKVLNMDGSQMIDDEQQGKIAEAEVIADRCTESLMTKGA 300

Query: 300 REILAEV 306
             +L+ +
Sbjct: 301 MSLLSTI 307


>UniRef50_B3E2H7 Porphobilinogen deaminase n=3 Tax=Proteobacteria RepID=HEM3_GEOLS
          Length = 312

 Score =  293 bits (751), Expect = 4e-78,   Method: Compositional matrix adjust.
 Identities = 160/303 (52%), Positives = 205/303 (67%), Gaps = 1/303 (0%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LRI TR S LALWQA++ K +L A +PG+ VELV + T GD ILD PLA+VGGKGLFVKE
Sbjct: 6   LRIGTRASQLALWQANWTKSELEARYPGIQVELVKIKTMGDKILDVPLAQVGGKGLFVKE 65

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E A+L    D+AVHSMKDVP EFP+GLGLV   +REDPRDAF+S+   +   L  G+ +
Sbjct: 66  IEEAMLRGEIDLAVHSMKDVPTEFPEGLGLVVTTKREDPRDAFISDKV-TFSELRQGARI 124

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTS+LRRQ QL + RPDL +  +RGNV TR+ KL     DA+ILA AGL RLG    +  
Sbjct: 125 GTSALRRQAQLLKARPDLEMVIIRGNVETRIRKLKEDNLDAVILAAAGLNRLGFTDVVTE 184

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L  + S+PA+GQGA+G+ECRLDD+ T E LA LNH +TA  V AERA+  R EGGCQVP
Sbjct: 185 LLDTDFSIPAIGQGALGLECRLDDNATIEALAFLNHADTAAAVAAERALLKRCEGGCQVP 244

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305
           I ++  +    + L   + + DG Q +R    G+  DA ++G  LA+ LL  G + IL +
Sbjct: 245 IAAHGTVSGDTLTLVGFIASVDGKQTVRDRISGSTADAVKLGTELADRLLAAGGKAILED 304

Query: 306 VYN 308
           VY 
Sbjct: 305 VYQ 307


>UniRef50_C9KL85 Hydroxymethylbilane synthase n=1 Tax=Mitsuokella multacida DSM
           20544 RepID=C9KL85_9FIRM
          Length = 315

 Score =  293 bits (749), Expect = 6e-78,   Method: Compositional matrix adjust.
 Identities = 162/307 (52%), Positives = 201/307 (65%), Gaps = 1/307 (0%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M ++ + I TR S LALWQA YV D L   +P L VE   M T+GD ILD PLAK+GGKG
Sbjct: 1   MKNDTIVIGTRSSKLALWQADYVADCLRKRYPELRVEKKLMTTKGDKILDAPLAKIGGKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LF KELE  +L    DIAVHS+KD+P E P+GL +  I ER DP DA VS  Y +L+ LP
Sbjct: 61  LFTKELEQDMLAGGIDIAVHSLKDMPTEVPEGLVISAITERFDPGDAVVSPKYRTLENLP 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ VGTSSLRR+ QL   RPDL I  LRGNV TRL KL+   +DAIILAVAGLKRLG  
Sbjct: 121 QGAKVGTSSLRRKAQLLHARPDLQISDLRGNVNTRLEKLEREHFDAIILAVAGLKRLGFA 180

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            RI   LP E+ LPAVGQGA+ IE R +D   R L+A LN   T     AERA   R+EG
Sbjct: 181 DRITEVLPREMVLPAVGQGALAIETRENDREVRNLIAFLNDEATVACARAERAFLARVEG 240

Query: 241 GCQVPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
           GCQVP+G YA    +G + + A++ + DG+++ R    G+  +AE +G +LA++LL  G 
Sbjct: 241 GCQVPVGVYAVPEAEGRLHVEAVIASLDGARLYRDAAVGSAAEAESLGTALADKLLAMGG 300

Query: 300 REILAEV 306
             IL E+
Sbjct: 301 IAILHEI 307


>UniRef50_C6HUG2 Porphobilinogen deaminase n=1 Tax=Leptospirillum ferrodiazotrophum
           RepID=C6HUG2_9BACT
          Length = 321

 Score =  292 bits (747), Expect = 1e-77,   Method: Compositional matrix adjust.
 Identities = 158/304 (51%), Positives = 206/304 (67%), Gaps = 2/304 (0%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR S LALWQA +V   ++    GL  EL  + T GD+IL  PL++VGGKGLFVKE
Sbjct: 10  IRIGTRGSELALWQARHVA-AMIRHTAGLESELTIIKTTGDMILSVPLSQVGGKGLFVKE 68

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E AL+    D+AVHSMKDVP   P+GL +  I  REDPRDAFVSN Y S  +LP G+ +
Sbjct: 69  IEEALIAGTIDLAVHSMKDVPAFLPEGLEIGAILSREDPRDAFVSNAYSSFSSLPPGARI 128

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSSLRR  QL +RRPDL   SLRGNVGTRL KLD  + DAIILA AGL RLG   RIR 
Sbjct: 129 GTSSLRRMAQLKKRRPDLRFESLRGNVGTRLRKLDENQIDAIILAAAGLIRLGFSDRIRE 188

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            LP E+SLPAVGQGA+G+ECR  D R R +LA ++  ET   V AER + + L+GGCQ+P
Sbjct: 189 YLPVELSLPAVGQGALGLECRTGDHRIRTILARMHDPETTACVLAERGVLSALDGGCQLP 248

Query: 246 IGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304
           I ++A  I  E I L A +   +G+ ++     G  ++A ++G+  A++LL+ G ++IL 
Sbjct: 249 IAAHARTISPEQIELIARILDVEGTTLLEEHTSGPAKEAHRLGVEAAQKLLSRGGQKILT 308

Query: 305 EVYN 308
           ++ +
Sbjct: 309 DILS 312


>UniRef50_Q8YVU6 Porphobilinogen deaminase n=50 Tax=cellular organisms
           RepID=HEM3_ANASP
          Length = 323

 Score =  291 bits (744), Expect = 3e-77,   Method: Compositional matrix adjust.
 Identities = 152/306 (49%), Positives = 201/306 (65%), Gaps = 3/306 (0%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            +RI +R+S LAL Q ++V+++L  S P +  E+  M T+GD ILD  LAK+G KGLF K
Sbjct: 11  TIRIGSRKSQLALVQTYWVREQLQNSFPDINFEVHTMSTQGDKILDVALAKIGDKGLFTK 70

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN-NYD--SLDALPA 121
           ELEV ++    D AVHS+KD+P   P+GL L  I ERE+P DA V + N+    +D LPA
Sbjct: 71  ELEVGMINEEIDFAVHSLKDLPTNLPEGLALAAITERENPADALVVHENFKDKQIDTLPA 130

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+++GTSSLRR  QL  + P L  + +RGN+ TRL+KLD GEYD +ILA AGL+RLG+  
Sbjct: 131 GAVIGTSSLRRLAQLRNQFPHLTFKDVRGNLNTRLAKLDAGEYDGLILAAAGLQRLGMGD 190

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
           R+   LP EISL AVGQGA+GIECR DD+    +L A+ H ET  R  AER+    LEGG
Sbjct: 191 RVHQILPKEISLHAVGQGALGIECRADDAELITVLKAIEHPETRDRCLAERSFLRSLEGG 250

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           CQVPIG   E+   E+ L  +V + DG  +++    G   DAE +GI LAE L   GA+E
Sbjct: 251 CQVPIGVNTEINGNELILTGVVASVDGQNLVKDTVSGNASDAEAIGIRLAELLREQGAQE 310

Query: 302 ILAEVY 307
           IL  ++
Sbjct: 311 ILNTIF 316


>UniRef50_Q3ACT3 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=HEM3_CARHZ
          Length = 311

 Score =  288 bits (736), Expect = 2e-76,   Method: Compositional matrix adjust.
 Identities = 146/299 (48%), Positives = 200/299 (66%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67
           + +R S LALWQ ++V ++L   HP +  ++V M T+GD ILD  LAK+G KGLF KELE
Sbjct: 7   VGSRDSALALWQTNWVVERLSKIHPEINFKIVTMKTKGDKILDVALAKIGDKGLFTKELE 66

Query: 68  VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127
            ALL    D+AVHSMKD+P   P+GL +   CERE P D F+S        LP G+ +GT
Sbjct: 67  HALLNKTIDMAVHSMKDLPTVLPEGLKIGAFCEREYPGDVFISPKGFKFLELPQGARIGT 126

Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAAL 187
           SSLRR  Q+   RPDL    LRGN+ TR  K++  + D IILA AG+KRLG E +I   L
Sbjct: 127 SSLRRIAQILAVRPDLQAIPLRGNLPTRFRKMEEMDLDGIILAYAGVKRLGYEDKITEML 186

Query: 188 PPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIG 247
             ++ LPAVGQG++G+E R DD+   ELL  ++H  T   + AERA   RLEGGCQ+PIG
Sbjct: 187 SFDLCLPAVGQGSIGVEIRADDTFIEELLKPIDHFATNRAIRAERAFLKRLEGGCQIPIG 246

Query: 248 SYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEV 306
           +Y+E+ +  + L+ +V + DG  +I+GE+ G+ ++ E++GISLAEELL  GA++IL E+
Sbjct: 247 AYSEVKENRLHLKGVVASLDGKLVIKGEKEGSIEEPEKVGISLAEELLTKGAQKILEEI 305


>UniRef50_D0LUE1 Porphobilinogen deaminase n=1 Tax=Haliangium ochraceum DSM 14365
           RepID=D0LUE1_HALO1
          Length = 320

 Score =  286 bits (732), Expect = 6e-76,   Method: Compositional matrix adjust.
 Identities = 161/314 (51%), Positives = 204/314 (64%), Gaps = 11/314 (3%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M +  + I+TR S LALWQAH+V+D++    P   VELV + T+GD ILD PL+K+GGK 
Sbjct: 1   MSERTIHISTRGSQLALWQAHHVRDEIRRVRPAWQVELVIIKTQGDKILDVPLSKIGGKA 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKE+E ALL+ RAD+AVHSMKDVP E   GL +     REDP DA  + +   LD L 
Sbjct: 61  LFVKEIEQALLDGRADVAVHSMKDVPAELAPGLFMAATSRREDPYDALCTRDGRGLDELA 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ +GTSSLRRQCQ+  RRPDL I  LRGNV TRL KLD+G +DA+ILA AGLKRLG  
Sbjct: 121 EGATLGTSSLRRQCQILARRPDLRIEMLRGNVPTRLGKLDDGSFDAVILAAAGLKRLGHG 180

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDS-RTRELLAALNH--HETA--LRVTAERAMN 235
            RI   L   + +PAVGQG +GIE R  D+   REL+ AL    H+ A   RV AERAM 
Sbjct: 181 ERISQRLDGGVCVPAVGQGVLGIETRQGDAPADRELVEALREALHDPAEERRVVAERAMM 240

Query: 236 TRLEGGCQVPIGSYAEL------IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGIS 289
             L G CQ P+ ++A        + G + +  L G PDGS+I+R +  G  +DA+ +G S
Sbjct: 241 AALGGSCQTPLAAHASYRGDSDPVAGTLVIEGLCGRPDGSEILRAQVEGRAEDAQALGSS 300

Query: 290 LAEELLNNGAREIL 303
           LAEEL   GA+ I+
Sbjct: 301 LAEELRGQGAQAII 314


>UniRef50_Q8DIE4 Porphobilinogen deaminase n=11 Tax=cellular organisms
           RepID=HEM3_THEEB
          Length = 320

 Score =  285 bits (729), Expect = 1e-75,   Method: Compositional matrix adjust.
 Identities = 150/305 (49%), Positives = 198/305 (64%), Gaps = 3/305 (0%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI +R+S LAL Q  +V+ +L   H     E+V M T+GD ILD  LAK+G KGLF KE
Sbjct: 9   VRIGSRKSQLALVQTEWVQAQLQTHHRDRAFEVVTMTTQGDNILDVALAKIGDKGLFTKE 68

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDSLDALPAG 122
           LE+++L    D+AVHS+KD+P + P GL L  I EREDP DA V        ++D LP G
Sbjct: 69  LELSMLRGETDLAVHSLKDLPTQLPDGLVLAAITEREDPADALVLGAKWTGHTIDTLPEG 128

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           +++GTSSLRR  QL    P L  + +RGN+ TRL+KLD GEYDA+ILAVAGL+RLG   R
Sbjct: 129 TVIGTSSLRRLAQLRHYYPHLTFKDVRGNLNTRLAKLDAGEYDALILAVAGLRRLGFGDR 188

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
           I   LP  +SL AVGQGA+GIECR +D+    L+  L H ET  R  AERA   +LEGGC
Sbjct: 189 ISQVLPATVSLYAVGQGALGIECRAEDADILALVKTLEHPETTARCLAERAFLRQLEGGC 248

Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302
           QVPIG +  + +G++ L  LV + DG ++++    G    AE++G  LA +L   GA EI
Sbjct: 249 QVPIGVHTVIENGQLTLTGLVASLDGQRLVKDSLTGDVATAEELGTRLALKLREQGASEI 308

Query: 303 LAEVY 307
           L E++
Sbjct: 309 LEEIF 313


>UniRef50_D1BNZ5 Porphobilinogen deaminase n=3 Tax=Veillonella RepID=D1BNZ5_VEIPT
          Length = 312

 Score =  276 bits (706), Expect = 7e-73,   Method: Compositional matrix adjust.
 Identities = 144/298 (48%), Positives = 192/298 (64%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR+S LALWQA ++  +L   +P + VELV   T+GD IL+ PLA+VGGKGLF  E
Sbjct: 5   IRIGTRKSALALWQAEHISAELQRLYPNITVELVHFNTKGDRILEKPLAQVGGKGLFTAE 64

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           LE A+     DIAVHS+KD+P E P+GL L  I  RE P DA VS  Y +LD LP G+ V
Sbjct: 65  LEEAMHAGDIDIAVHSLKDMPTELPEGLTLGAISAREVPYDALVSPVYKTLDKLPQGARV 124

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSSLRRQ QL   RPDL +  +RGNV TRLSK++  + D +ILA AGLKRLGLE +I  
Sbjct: 125 GTSSLRRQAQLLHVRPDLKVEVIRGNVQTRLSKIETEKLDGVILAQAGLKRLGLEDQITQ 184

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
               +  +PAVGQGA+ IECR DD+   ++L  +N   T   V  ER+   +L GGCQVP
Sbjct: 185 VFKADEMIPAVGQGALAIECRADDTEMLDMLDPINDEATRYAVEGERSFLRQLNGGCQVP 244

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           +G +  +  G++ L+A++ + DG  +  GE  G  +  E +G +LA+ L   G + I+
Sbjct: 245 MGVHGTINKGQLTLKAMIASLDGKTVYEGEISGPAKKGEILGKNLAKALYEEGGKRIV 302


>UniRef50_A9FDP9 Porphobilinogen deaminase n=1 Tax=Sorangium cellulosum 'So ce 56'
           RepID=HEM3_SORC5
          Length = 300

 Score =  276 bits (705), Expect = 8e-73,   Method: Compositional matrix adjust.
 Identities = 152/293 (51%), Positives = 195/293 (66%), Gaps = 4/293 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L +ATR+S LAL Q+      L A+ P L +  + +VT GD   D  L  +GGKGLF+KE
Sbjct: 5   LTLATRRSALALAQSRAFARSLEAAVPDLSLRELEVVTSGDKTQDRSLQDIGGKGLFIKE 64

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           LE ALL+ RAD AVHS+KDVP E    L L  I  REDPRDA V+ +   L  LPAG+ V
Sbjct: 65  LEEALLDRRADFAVHSIKDVPAEIAPALCLACIPAREDPRDALVTRSGALLAELPAGARV 124

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSSLRR   L E RPDL+I  +RGNV TRL K+ +G +DA++LA+AGLKRLGLE+R   
Sbjct: 125 GTSSLRRAVALREARPDLVIEPVRGNVDTRLRKVFDGVFDAVVLALAGLKRLGLEARATE 184

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L PE+SLPA+GQGA+GIECR  D   R++L  L   ET + V+AERA+   +EG C+ P
Sbjct: 185 VLSPEVSLPAIGQGALGIECRTADDSVRDVLGTLADAETTICVSAERAVMAAVEGSCRTP 244

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERR----GAPQDAEQMGISLAEEL 294
           + +YA    G +WLRAL+  PDGS++ R ERR    G  ++AE++G  L  EL
Sbjct: 245 VAAYAVRDGGALWLRALLAEPDGSRLRRAERRLSWPGNTREAERLGADLGAEL 297


>UniRef50_A7NKU8 Porphobilinogen deaminase n=5 Tax=Bacteria RepID=HEM3_ROSCS
          Length = 303

 Score =  275 bits (704), Expect = 1e-72,   Method: Compositional matrix adjust.
 Identities = 152/301 (50%), Positives = 194/301 (64%), Gaps = 1/301 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           N L I TR S LAL Q H ++D L A+HPGL V +  + TRGD+ILD PL  +G KGLFV
Sbjct: 3   NSLTIGTRASKLALVQTHMIRDALQAAHPGLTVAVERITTRGDIILDRPLNAIGDKGLFV 62

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
            E+E A+   R D+AVHS KD+P   P  + L     R DPRDA V+    +L +LP G+
Sbjct: 63  VEIEEAMRAGRVDLAVHSAKDLPSTLPPDMTLAVCPRRADPRDALVAQPGMTLASLPHGA 122

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            VGTSSLRR CQL   RPDL +  LRGNV TRL KL  G+YDAI+LA AGLKRLGLE  I
Sbjct: 123 RVGTSSLRRACQLRALRPDLTLLDLRGNVDTRLRKLREGQYDAIVLAAAGLKRLGLEEVI 182

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              L P++ +PAVGQG +G+E R  D     LLA L+       +TAERA   R+ GGC+
Sbjct: 183 TELLEPDVLIPAVGQGIIGVEARAGDDEVLRLLAPLDDPAARAAITAERAFLARIGGGCR 242

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           VP+G+ A L   E+ L  ++GA DG +++RG R G+  D   +G +LAEELL+ G + +L
Sbjct: 243 VPVGALALLEGDELLLYGMIGALDG-RMVRGMRSGSASDPAGLGSALAEELLDAGGQALL 301

Query: 304 A 304
           A
Sbjct: 302 A 302


>UniRef50_Q31PM2 Porphobilinogen deaminase n=8 Tax=cellular organisms
           RepID=HEM3_SYNE7
          Length = 320

 Score =  275 bits (704), Expect = 1e-72,   Method: Compositional matrix adjust.
 Identities = 150/305 (49%), Positives = 200/305 (65%), Gaps = 3/305 (0%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI +R+S LAL Q H+V+ +L   +P    ++  M T+GD+ILD  LAK+G KGLF KE
Sbjct: 9   IRIGSRKSQLALVQTHWVQGELQRLYPDRQFDVQTMSTQGDIILDVALAKIGDKGLFTKE 68

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLDALPAG 122
           LEVA+L    D AVHS+KD+P   P+GL L  + EREDP DA V ++      L+ LP G
Sbjct: 69  LEVAMLAGEVDFAVHSLKDLPTRLPEGLILGCVTEREDPADALVVHDRFKDHQLETLPEG 128

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           +++GTSSLRR  QL    P L  + +RGN+ TRL+KLD GEYDA+ILA AGL+RL +  R
Sbjct: 129 TVIGTSSLRRLAQLRHHYPHLQFKDVRGNLNTRLAKLDAGEYDALILAAAGLQRLSMADR 188

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
           I   +P  +SL AVGQGA+GIECR +D    ELL AL H  T+ R  AERA    LEGGC
Sbjct: 189 IHQLIPAAVSLHAVGQGALGIECRAEDPEILELLKALEHEPTSQRCLAERAFLRELEGGC 248

Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302
           QVPIG    + DG + L  +V + DG +++R +  G   D E +G++LA +L   GA+EI
Sbjct: 249 QVPIGVNTAIADGTLTLTGMVASLDGQRLLRDQVSGPTSDPEALGLALAAQLKAQGAKEI 308

Query: 303 LAEVY 307
           L E++
Sbjct: 309 LDEIF 313


>UniRef50_Q4HT06 Porphobilinogen deaminase n=1 Tax=Campylobacter upsaliensis RM3195
           RepID=Q4HT06_CAMUP
          Length = 308

 Score =  275 bits (703), Expect = 2e-72,   Method: Compositional matrix adjust.
 Identities = 151/300 (50%), Positives = 201/300 (67%), Gaps = 4/300 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L IATR+SPLALWQ+ +V D L  +H G+ V L    T+GD++LD+PLAK+GGKGLF KE
Sbjct: 4   LIIATRKSPLALWQSEFVADILRKTH-GIEVHLEGFSTKGDILLDSPLAKIGGKGLFTKE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           LE A+LEN+A +AVHS+KDVP   PQGL L  +  RED  DA +S  Y  L+ALP  + V
Sbjct: 63  LENAMLENKAHLAVHSLKDVPSFLPQGLVLAALSVREDDTDALLSELYKDLNALPQNAKV 122

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GT+SLRR+ QL   RPDL I +LRGNV +RL +L  GE+DAIILA AG+KRLGLES ++ 
Sbjct: 123 GTTSLRRKMQLLSLRPDLHIINLRGNVNSRLKRLKGGEFDAIILASAGVKRLGLESEVKF 182

Query: 186 A--LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
                 +  +PA  QG +GI+   D +    LL  LN  ++ +  T ER     LEGGCQ
Sbjct: 183 IYRFSKDELVPAATQGILGIQSP-DKNEILTLLQCLNDEKSLIESTVERDFIRTLEGGCQ 241

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           VPIG  AEL+  +I +R+++G PDGS+I+R +R    ++ +  G  LA E +  GA+E+L
Sbjct: 242 VPIGINAELMGEQITVRSILGLPDGSEILRDKRIILKKNYQGFGERLALEFIKRGAKELL 301


>UniRef50_C0Q9U2 HemC n=2 Tax=Bacteria RepID=C0Q9U2_DESAH
          Length = 325

 Score =  275 bits (703), Expect = 2e-72,   Method: Compositional matrix adjust.
 Identities = 146/302 (48%), Positives = 197/302 (65%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   ++I TR S LALWQA++VKD++    P   VE++ + T GD+I+D PL+ VGGKGL
Sbjct: 19  MKKTIKIGTRGSKLALWQANHVKDRIEDQFPETEVEIMTIKTTGDMIVDRPLSMVGGKGL 78

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FVKE+E ALLE+  D+AVHSMKD+P E P GL +  +  RE+P D  +SNN  SL  LP 
Sbjct: 79  FVKEIEKALLESTIDMAVHSMKDMPGELPPGLVIGAVPARENPFDVLISNNNLSLADLPK 138

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ +GTSSLRR  Q+   RPD+   S+RGN+ TRL KL  GE+DA +LA AGL RLG+++
Sbjct: 139 GARIGTSSLRRASQIKHARPDIETASIRGNLDTRLKKLAAGEFDATLLAAAGLIRLGMKT 198

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
            I       I +PAVGQGA+ IE R +D     +LA LNH ET   V+ ERA   RL+G 
Sbjct: 199 VITQYFDETIMIPAVGQGALCIESRQEDLDIAPVLAFLNHGETHTVVSGERAFLRRLDGS 258

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           C +P+  +  L D  + L  LV + DG  I++    G P+D ++ GI+LAE LL+ GA +
Sbjct: 259 CHIPVACFGRLEDHRVILTGLVASEDGRTILKETVAGTPEDPQKAGIALAETLLSKGADK 318

Query: 302 IL 303
           IL
Sbjct: 319 IL 320


>UniRef50_B3QWI1 Porphobilinogen deaminase n=12 Tax=Chlorobiaceae RepID=HEM3_CHLT3
          Length = 314

 Score =  273 bits (697), Expect = 7e-72,   Method: Compositional matrix adjust.
 Identities = 145/314 (46%), Positives = 196/314 (62%), Gaps = 4/314 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   L I TR SPLALWQA ++K +L   +P L + L  + T GD ILD PLAK+G KGL
Sbjct: 1   MKKALIIGTRSSPLALWQAEFIKAELSKHYPSLDISLRHIKTTGDKILDAPLAKIGDKGL 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F +E+E  +L N  D+AVHS+KD+P E P+GL +  I ERED RD  +S    +L  LP 
Sbjct: 61  FTREIEHVMLRNEIDLAVHSLKDLPTETPEGLVITAITEREDNRDVLISKGKYTLKTLPQ 120

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+IV TSSLRR+ QL   RPDL +  +RGN+ TR  + + G+ +A++LA AG+ RL    
Sbjct: 121 GAIVATSSLRRRSQLLHLRPDLEVIDMRGNLNTRFKRFEEGDAEAMLLAFAGVHRLEFSE 180

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
            I   +  +  LPAVGQGA+GIE R+DD  TRELL  LNH ET L    ER++   LEGG
Sbjct: 181 HIAEIISFDDILPAVGQGALGIETRIDDEETRELLKVLNHAETELCTKCERSLLRTLEGG 240

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRG----ERRGAPQDAEQMGISLAEELLNN 297
           CQ+PIG++A + +G       VG+ DG + I+     E     ++AEQ+GI +A+     
Sbjct: 241 CQIPIGAHARIENGTFHFATYVGSIDGKRAIKKSLSRENVTTVEEAEQIGIEVADAARAA 300

Query: 298 GAREILAEVYNGDA 311
           GA EIL E+   +A
Sbjct: 301 GANEILCEIRTDNA 314


>UniRef50_A3MLK5 Porphobilinogen deaminase n=155 Tax=Proteobacteria RepID=HEM3_BURM7
          Length = 329

 Score =  270 bits (691), Expect = 4e-71,   Method: Compositional matrix adjust.
 Identities = 151/270 (55%), Positives = 191/270 (70%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           L   L IA+R+S LA+WQA +V+D L   +P   V+++ M TRGD ILD  L+KVGGKGL
Sbjct: 10  LPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGL 69

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FVKELE AL + RAD+AVHS+KDVP+  P+G  L  +  REDPRDAFVSN+Y SLDALPA
Sbjct: 70  FVKELESALADGRADLAVHSLKDVPMALPEGFALAAVMSREDPRDAFVSNDYASLDALPA 129

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G++VGTSSLRR+  L  R P L +R LRGN+ TRL+KLD G+Y AIILA AGLKRLGL +
Sbjct: 130 GAVVGTSSLRREAMLRARHPRLDVRPLRGNLDTRLAKLDRGDYAAIILAAAGLKRLGLAA 189

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
           RIRA L  + SLPA GQGA+GIE     +     LA L+ H +AL V AERA++  L G 
Sbjct: 190 RIRALLDVDDSLPAAGQGALGIEIAARRADVAAWLAPLHDHASALAVEAERAVSRALGGS 249

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQI 271
           C+VP+ ++A    GE+ L   V   DG+++
Sbjct: 250 CEVPLAAHAVWRGGELHLTGSVSTTDGARV 279


>UniRef50_Q8D2W2 HemC protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of
           Glossina brevipalpis RepID=Q8D2W2_WIGBR
          Length = 291

 Score =  268 bits (684), Expect = 3e-70,   Method: Compositional matrix adjust.
 Identities = 132/284 (46%), Positives = 192/284 (67%), Gaps = 1/284 (0%)

Query: 24  KDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMK 83
           K KL+  HP L ++LVP++T GD+I          KGLF+KELE +LL+ ++DIAVHSMK
Sbjct: 7   KKKLLHYHPKLNIKLVPILTTGDLINKIRNNITNEKGLFIKELEKSLLKYQSDIAVHSMK 66

Query: 84  DVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDL 143
           D    F   LGL  IC+R+DPRDA VSN Y+++ +LP  + VGTSSLRR+CQL   RPDL
Sbjct: 67  DFSSSFLDSLGLAAICKRDDPRDAIVSNYYNNIISLPNNAKVGTSSLRRKCQLLSIRPDL 126

Query: 144 IIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGI 203
            I   +GN+ +RL KL+ G +DA+ILA A LKRL +  ++   + P   LPA+GQG++ I
Sbjct: 127 KIFPCKGNIHSRLKKLNQGVFDALILATAALKRLKINEQMYTPIDPSYLLPAMGQGSIAI 186

Query: 204 ECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID-GEIWLRAL 262
           +CRL D++  +++  +N+ +TAL + +E+ + + L  GC+VPIGSYA++ +   IW+RAL
Sbjct: 187 QCRLYDNKIIDIVRNINNKKTALCINSEKIVVSMLGTGCRVPIGSYAKIENKNTIWIRAL 246

Query: 263 VGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEV 306
           VG+ DGS IIR E +    +AE++     + L+N GA+ IL + 
Sbjct: 247 VGSIDGSNIIRSEGKSCVSNAEKLSKKQVKNLINLGAKNILKKF 290


>UniRef50_A6TJD5 Porphobilinogen deaminase n=2 Tax=Firmicutes RepID=HEM3_ALKMQ
          Length = 316

 Score =  264 bits (675), Expect = 3e-69,   Method: Compositional matrix adjust.
 Identities = 141/306 (46%), Positives = 192/306 (62%), Gaps = 1/306 (0%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            ++I +R S LAL QA  + + L    P    E++ + T GD ILD  L K+GGKGLFVK
Sbjct: 3   TIKIGSRASQLALVQAEIIINMLKEKFPQYTYEIIKITTLGDRILDKTLDKIGGKGLFVK 62

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           E++ AL E + D+A+HSMKD+P E P+ L L  I +REDPRD  ++    SL+ LP G++
Sbjct: 63  EIQKALAEEKIDLAIHSMKDMPGETPEELVLGAITKREDPRDVLITRENKSLEELPKGAV 122

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +G+SSLRRQ Q+   R D+ +  +RGNVGTRL K++    D +ILA AGL RLGL+ +I 
Sbjct: 123 IGSSSLRRQAQVMALRGDIKVVPIRGNVGTRLGKIETESLDGVILAAAGLNRLGLKEKIS 182

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
           + L  E   PAVGQGA+G E R  D    E+L A+NH ET   V AERA    LEGGC V
Sbjct: 183 SYLEIEDFTPAVGQGALGCEARRKDIEMLEMLLAINHEETYRCVMAERAFLKLLEGGCHV 242

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304
           PIG+Y +    E+ +  +V + DG ++I+ +  G   D + +GI L E L+  GA+EIL 
Sbjct: 243 PIGAYGQQQGQELHMTGMVASSDGRRVIKEQVMGDIADFQALGIQLGETLIEKGAKEIL- 301

Query: 305 EVYNGD 310
           E  N D
Sbjct: 302 ETVNTD 307


>UniRef50_Q2RJ26 Porphobilinogen deaminase n=5 Tax=Clostridia RepID=HEM3_MOOTA
          Length = 313

 Score =  263 bits (673), Expect = 5e-69,   Method: Compositional matrix adjust.
 Identities = 150/301 (49%), Positives = 193/301 (64%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +++ +R+S LA WQA +V   L  + PGL   LV + T+GD ILD  LA++G KGLF KE
Sbjct: 4   IKVGSRESELARWQARWVIQALEKAWPGLSCRLVTLKTKGDKILDVALARIGDKGLFTKE 63

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           LE+ALL+   D+AVHSMKD+P   P+GL +  I  REDP D  VS    +L  LP  + V
Sbjct: 64  LELALLDGAIDLAVHSMKDMPTTLPEGLVIGAIGPREDPADVLVSPEGYTLATLPIKARV 123

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSSLRR+ QLA  RPDL +  LRGNV TRL+K++     AI+LA AGLKRL     +  
Sbjct: 124 GTSSLRRKAQLAYARPDLELVDLRGNVPTRLAKMERDGLTAIVLAAAGLKRLNHGQVLGE 183

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            +P  I LPAVGQGA+G+E R  D R  EL+AA+NH  TA  V AERA    LEGGCQVP
Sbjct: 184 PIPYHICLPAVGQGAIGVEIRAGDRRVAELVAAINHPPTAAAVRAERAYLRALEGGCQVP 243

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305
           I + A + D  + L+ +V + DG +++R    G+ +D E  G  LA +LL  GA EIL E
Sbjct: 244 IAALATVEDTALVLQGMVASLDGREMLRDIASGSTRDPEAAGRELARKLLARGAGEILQE 303

Query: 306 V 306
           V
Sbjct: 304 V 304


>UniRef50_A8PKX6 Porphobilinogen deaminase n=2 Tax=Gammaproteobacteria
           RepID=A8PKX6_9COXI
          Length = 311

 Score =  262 bits (670), Expect = 1e-68,   Method: Compositional matrix adjust.
 Identities = 152/301 (50%), Positives = 194/301 (64%), Gaps = 2/301 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             LRIATR+SPLA WQA  +K++L    P L + L+P VT GD    + L + GGKGLFV
Sbjct: 5   KFLRIATRKSPLAYWQATSIKNQLEKIFPFLKITLLPFVTEGDRPSHS-LNQWGGKGLFV 63

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KELE ALL  +ADIAVHS+KD+P+   +GL L  IC+R DPRD  +S +      LP GS
Sbjct: 64  KELEAALLHGQADIAVHSLKDLPMTLEKGLVLGAICKRCDPRDVLISRSDRLFTQLPPGS 123

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            VGTSSLRRQ QL   RPDL I  LRGN+GTRL+KL  GE+DAIILA AGL RL     I
Sbjct: 124 YVGTSSLRRQSQLLALRPDLKIGVLRGNIGTRLNKLAAGEFDAIILAAAGLIRLKKTECI 183

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
                 +  LPA GQGA+GIEC  +D  +   ++AL H  T   V AERA++  L GGCQ
Sbjct: 184 SEYFEIDHFLPAPGQGALGIECHENDEESLTYISALIHPITHSCVLAERALSRELGGGCQ 243

Query: 244 VPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302
           VP+ +YA  +  + I L+A VG+ DG+  I+ E++G   +AE++G   A++L   G  EI
Sbjct: 244 VPLAAYAASLGQDFIRLQAFVGSSDGTTQIKVEKQGPRVEAEKIGFLAAQDLRALGVEEI 303

Query: 303 L 303
           L
Sbjct: 304 L 304


>UniRef50_D2R3S6 Porphobilinogen deaminase n=2 Tax=Planctomycetaceae
           RepID=D2R3S6_9PLAN
          Length = 311

 Score =  258 bits (658), Expect = 2e-67,   Method: Compositional matrix adjust.
 Identities = 144/299 (48%), Positives = 192/299 (64%), Gaps = 2/299 (0%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LR+ TR SPLA WQA +V+D+L+A+  G+ VE++ + T GD     PL ++GG+GLF KE
Sbjct: 7   LRLGTRASPLARWQADWVRDQLIAA--GIDVEMILITTEGDQQTSQPLGQIGGQGLFTKE 64

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           ++  LL    D+AVHS+KD+P     GL L  + ERED  D  +     SL  LP+G+ +
Sbjct: 65  IQRRLLAGDIDLAVHSLKDLPTLPIDGLSLAAVPEREDTADILIGPAGTSLATLPSGAKI 124

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GT SLRR+ QL   R DL I  +RGNV TRL KLD G+Y AIILA AGLKRL L+ R+  
Sbjct: 125 GTGSLRRKAQLLHARADLEILDIRGNVDTRLRKLDEGQYHAIILAAAGLKRLKLDDRMTE 184

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L   + LPAVGQGA+GIE R DD  TR+LLA L+H  T   V AER++   L  GC  P
Sbjct: 185 RLEAPLMLPAVGQGALGIESRSDDPTTRKLLAPLSHAPTLQAVIAERSLLAALRAGCLAP 244

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304
           +G++A+++DG++ L A+V + DG   +      AP DA Q+G  +AE L   GA E+LA
Sbjct: 245 VGAHAQVVDGQLTLAAVVLSIDGQSRLFASLTSAPADAAQLGEEVAELLRQQGATELLA 303


>UniRef50_A3ETN3 Porphobilinogen deaminase n=2 Tax=Leptospirillum sp. Group II
           RepID=A3ETN3_9BACT
          Length = 314

 Score =  256 bits (655), Expect = 5e-67,   Method: Compositional matrix adjust.
 Identities = 153/318 (48%), Positives = 196/318 (61%), Gaps = 17/318 (5%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           ML   L+I +R S LALWQA +V   L+ S  G++ E+V + T GD+ILD  L++VGGKG
Sbjct: 1   MLPTPLKIGSRGSELALWQARHVA-SLIESVSGVLPEIVVIKTTGDIILDRQLSEVGGKG 59

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKE+E ALL    D+AVHSMKDVP   P GL L     REDPRD F+S +Y  + +LP
Sbjct: 60  LFVKEIEEALLRKEIDLAVHSMKDVPAFLPPGLTLAATLTREDPRDVFLSPHYPDIKSLP 119

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
             + VGTSSLRR  Q+ E R DL    LRGNVGTR+ K++ G  DAIILA AGL RLG  
Sbjct: 120 QKARVGTSSLRRLAQIREIRNDLEFIPLRGNVGTRIRKMEEGVVDAIILAGAGLLRLGHA 179

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
           +R+R  + P + LPA+GQGA+G+E R DD  T  L+ +L+   T L V AER +   L G
Sbjct: 180 NRVREWISPRVLLPAIGQGALGLEIRTDDETTGTLVRSLSDESTHLSVAAERGVLQSLNG 239

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQI-IRGERRGAPQ---------DAEQMGISL 290
           GCQVPI +YA      +W +    + +G  + I G RR   +         DA QMGI L
Sbjct: 240 GCQVPIAAYA------VWEKNRTLSLEGRVLDISGTRRIHARETRDIVTIDDAYQMGIDL 293

Query: 291 AEELLNNGAREILAEVYN 308
              LL++GA EIL  +  
Sbjct: 294 GNRLLSDGAEEILNSILK 311


>UniRef50_C8WXM9 Porphobilinogen deaminase n=2 Tax=Alicyclobacillus acidocaldarius
           RepID=C8WXM9_ALIAD
          Length = 305

 Score =  256 bits (654), Expect = 8e-67,   Method: Compositional matrix adjust.
 Identities = 151/300 (50%), Positives = 196/300 (65%), Gaps = 2/300 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             LR+ATR+S LAL Q ++V D L     G+  ELVP+ TRGD I+D  L++VGGKGLFV
Sbjct: 2   RTLRVATRRSALALTQTNHVVDLLKQVAHGVEFELVPIRTRGDEIVDRALSEVGGKGLFV 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
            ++E AL   +AD+AVHS+KDVP E   GL +  +  REDPRDA +S     L  LP G+
Sbjct: 62  ADIEDALATGQADLAVHSLKDVPFELRDGLTIGAVPPREDPRDALISRTGQGLFDLPPGA 121

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            VGTSSLRRQ  L   RPDL + +LRGNV TRL +L+ G++DAI+LA +GL RLGL  RI
Sbjct: 122 RVGTSSLRRQAALRRLRPDLCVETLRGNVDTRLRRLEEGQFDAIVLAASGLHRLGLAERI 181

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              LP +  +PAVGQGA+ IECR +D      LAA+   +    V AERA  +RLEG CQ
Sbjct: 182 TEYLPVDRFVPAVGQGALAIECRAEDDEVMRHLAAIADPDATRAVEAERAFLSRLEGSCQ 241

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           VPIG+YAE +  E+ L A V  P G   ++ ER G   +A  +G+++AEE+L  GA + L
Sbjct: 242 VPIGAYAEPVGHELRLIAFVADPSGIHHLQLERTG--DEARALGVAMAEEMLRQGAEDWL 299


>UniRef50_A8LIJ6 Porphobilinogen deaminase n=11 Tax=Alphaproteobacteria
           RepID=A8LIJ6_DINSH
          Length = 347

 Score =  254 bits (650), Expect = 2e-66,   Method: Compositional matrix adjust.
 Identities = 144/294 (48%), Positives = 190/294 (64%), Gaps = 2/294 (0%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           D+ L+I TR S LAL QAH  + +L A+   P    E+V + T GD I D  L+++GGKG
Sbjct: 38  DSPLKIGTRGSLLALAQAHETRARLSAAFDLPEEAFEIVVIKTTGDRIQDRSLSEIGGKG 97

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LF +E+E A+L+   DIAVHSMKD+PV+ P GL L T   RED RDAFV+ +  +L  LP
Sbjct: 98  LFTREIEDAMLDGSIDIAVHSMKDMPVDTPAGLALDTYLPREDVRDAFVTLDGGTLADLP 157

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G++VG+SSLRR+ QLA RRPDL +   RGNV TR+ KL +G   A  LA+AGL RLG++
Sbjct: 158 EGAVVGSSSLRRRAQLAHRRPDLQLVEFRGNVQTRMKKLGDGVAHATFLAMAGLNRLGMD 217

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
              R+A+ PE  LPAV QG +GIE R DD R  E+LAA++   +  R+  ERA  + L+G
Sbjct: 218 EVPRSAIAPEDMLPAVAQGCIGIERRADDPRAAEMLAAIHDGPSGHRLACERAYLSALDG 277

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
            CQ PI   AEL  G I LRA +  PDGS+++        +DA +MG  +AE L
Sbjct: 278 SCQTPIAGLAELDGGSIHLRAEILRPDGSEVLSDSETAPVEDAAKMGREVAERL 331


>UniRef50_Q65GK1 Porphobilinogen deaminase n=98 Tax=Bacillales RepID=HEM3_BACLD
          Length = 313

 Score =  254 bits (649), Expect = 3e-66,   Method: Compositional matrix adjust.
 Identities = 143/301 (47%), Positives = 187/301 (62%), Gaps = 4/301 (1%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67
           + +R+S LA+ Q  +V  KL   +P    E+  +VT+GD ILD  L+KVGGKGLFVKE+E
Sbjct: 6   VGSRRSKLAMTQTKWVIKKLEELNPDFTFEIKEIVTKGDRILDVTLSKVGGKGLFVKEIE 65

Query: 68  VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127
            A+L    D+AVHSMKD+P   P+GL +  I +RED RD  +S     L  L  G++VGT
Sbjct: 66  QAMLSGEIDMAVHSMKDMPSVLPEGLMVGCIPKREDARDVLISKGRQKLADLKQGAVVGT 125

Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR-IRAA 186
           SSLRR  QL + RPDL I+ +RGN+ TRL KL+  +YDAIILA AGL R+G +   +   
Sbjct: 126 SSLRRSAQLLQMRPDLEIKWIRGNIDTRLKKLETEDYDAIILAAAGLSRMGWKDDVVTEF 185

Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246
           L PE  LPAVGQGA+ IECR  D     L + LN   T L VTAERA    +EGGCQVPI
Sbjct: 186 LDPESCLPAVGQGALAIECRGSDEELLSLFSRLNDRYTQLTVTAERAFLHAMEGGCQVPI 245

Query: 247 GSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305
             +A++  DG I L  LV +PDG  + R   +G  +D E +G   A  +   GA+ ++  
Sbjct: 246 AGFAKMDEDGVIELTGLVASPDGKTVYRETVKG--KDPEAVGRECAAVMSEKGAKALIDR 303

Query: 306 V 306
           V
Sbjct: 304 V 304


>UniRef50_A6Q7Y4 Porphobilinogen deaminase n=7 Tax=Epsilonproteobacteria
           RepID=HEM3_SULNB
          Length = 323

 Score =  253 bits (646), Expect = 6e-66,   Method: Compositional matrix adjust.
 Identities = 136/306 (44%), Positives = 188/306 (61%), Gaps = 6/306 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L IATR S LALWQA+++K+++  + P + VEL  + ++GD ILD PLA VGGKG F KE
Sbjct: 4   LVIATRASNLALWQAYHIKERIETAFPEVRVELNEITSKGDKILDKPLALVGGKGHFTKE 63

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           LE  ++   A +AVHS+KDVP   P+GL L  I ER+D  D F+S+ Y SL  LP G++V
Sbjct: 64  LEDEMIAGNAHLAVHSLKDVPTYIPEGLELCAITERQDQSDVFLSHTYKSLSELPEGAVV 123

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GT+SLRR+ QL E+RPDL ++ LRGNV TRL KL  G+YDAIILA  GL RL L   I  
Sbjct: 124 GTTSLRRRMQLLEKRPDLKVKDLRGNVNTRLRKLKEGQYDAIILAYIGLYRLDLLKDIPY 183

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
               +  +P +GQ A+GIE   ++ R RE+   LNH  T +    ER   + +  GC  P
Sbjct: 184 VEKLDFFIPPMGQAALGIEIVANNDRIREIAMTLNHEPTFICTKVERDFISVIGAGCSAP 243

Query: 246 IGSYAELIDGE------IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
           +   A +   E      I +RA++G PDG+ I+         +A+ +G  LA+ ++  GA
Sbjct: 244 VAVNATMDKKEDDKVPTISVRAMIGYPDGTHILHKSLTVPLNEADILGDELAQAMIEEGA 303

Query: 300 REILAE 305
            +IL +
Sbjct: 304 LDILEQ 309


>UniRef50_C9R7U0 Porphobilinogen deaminase n=1 Tax=Ammonifex degensii KC4
           RepID=C9R7U0_AMMDK
          Length = 308

 Score =  249 bits (637), Expect = 6e-65,   Method: Compositional matrix adjust.
 Identities = 144/301 (47%), Positives = 186/301 (61%), Gaps = 1/301 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             LRI TR S LAL Q   V   L    P    E+V + T GD + +  L ++GGKGLF 
Sbjct: 6   RCLRIGTRGSDLALAQTEQVLQILRERWPHYTYEIVKIKTTGDKVRNLALPRIGGKGLFT 65

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KELEVALLE + D+AVHS+KD+P E P+ L +  +  RE P D  +S     L+ LP G+
Sbjct: 66  KELEVALLEEKIDLAVHSLKDLPTELPEELCVGAVLPREHPGDVLISLTGAGLEDLPEGA 125

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            +GTSSLRRQ QL   RPDL    LRGNV TRL KL+ GE +A++LA AGL+RL L+   
Sbjct: 126 RIGTSSLRRQAQLKAARPDLNFVPLRGNVPTRLRKLEKGECEAVVLAWAGLRRLRLDLTG 185

Query: 184 RAA-LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
           R   LP ++ LPAV QGA+G+E R +D   R+++  L+   T L VTAERA    L GGC
Sbjct: 186 RMTLLPYQVCLPAVAQGAIGVEMRKEDRELRKMVEVLDDPTTRLEVTAERAFLRWLGGGC 245

Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302
            VPI + A +   EI L  LV  P+G +I+RG+  G+    E++GI LAE LL  GA E+
Sbjct: 246 HVPIAALARVAGAEILLEGLVADPEGKRIVRGQESGSTAYPEEVGIRLAERLLREGAEEL 305

Query: 303 L 303
           L
Sbjct: 306 L 306


>UniRef50_B2A1G7 Porphobilinogen deaminase n=1 Tax=Natranaerobius thermophilus
           JW/NM-WN-LF RepID=HEM3_NATTJ
          Length = 311

 Score =  249 bits (637), Expect = 6e-65,   Method: Compositional matrix adjust.
 Identities = 137/309 (44%), Positives = 196/309 (63%), Gaps = 5/309 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LRI TR+S LAL Q ++V ++L   +P + +E+  + T+GD +L+  L+KVGGKGLF+KE
Sbjct: 3   LRIGTRRSQLALDQTNWVVEQLKTHYPDIEIEIKKIETKGDQLLNVSLSKVGGKGLFLKE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           ++ ALL+   D+AVHSMKD+P E  + L +  I +R DP DA +SNN  ++D LP  + +
Sbjct: 63  IQNALLQGEIDLAVHSMKDIPTETTEDLEICAITKRVDPLDALISNNDITIDELPENAKI 122

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESRIR 184
           GTSSLRR  QL   R DL I  +RGN+ TR++KL    E DA++LA AGL R G+   I 
Sbjct: 123 GTSSLRRGSQLKAYRNDLQIIPIRGNINTRMNKLQELPELDAVVLAKAGLVRSGMTDSIS 182

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             + PEI +P  GQGA+G+E R D+   +E LA L+  E+   + AERA   RL G C V
Sbjct: 183 QNISPEIIVPCPGQGALGLEIRHDNENLKEKLAVLDDSESRKAIGAERAFLNRLGGSCHV 242

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQ----MGISLAEELLNNGAR 300
           P+G+YAE+I  E+ L  +V + DG  +I+   +    D  +    +G  LAEEL+  GA 
Sbjct: 243 PVGAYAEIISNELHLTGVVASEDGQDVIKRSVQTHLSDNNKIPSTLGNDLAEELIELGAN 302

Query: 301 EILAEVYNG 309
           +IL+E+  G
Sbjct: 303 KILSELKEG 311


>UniRef50_Q4L709 Porphobilinogen deaminase n=88 Tax=Bacillales RepID=HEM3_STAHJ
          Length = 310

 Score =  249 bits (635), Expect = 1e-64,   Method: Compositional matrix adjust.
 Identities = 139/303 (45%), Positives = 196/303 (64%), Gaps = 4/303 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L + +R+S LAL Q+    DKL A  P L +E+  +VT+GD I++  L+KVGGKGLFVKE
Sbjct: 4   LVVGSRRSKLALTQSQQFIDKLKAVDPTLEIEIKEIVTKGDRIVNKQLSKVGGKGLFVKE 63

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           ++  L +   D+A+HS+KDVP   P+GL L  I +RE P DA++S N+  L+ LP GSI+
Sbjct: 64  IQQELFDKEIDMAIHSLKDVPSIIPEGLTLGCIPDREVPFDAYISKNHIPLNELPDGSII 123

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI-R 184
           GTSSLRR  Q+  + P+L I+ +RGN+ TRL KL+  +YDAIILA AGL+R+G    I  
Sbjct: 124 GTSSLRRGAQILSKYPNLEIKWIRGNIDTRLKKLEIEDYDAIILAAAGLRRMGWSDDIVT 183

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L  +I LPA+GQGA+GIECR DD    ELL+ +++   A  VTAER   + ++G CQV
Sbjct: 184 TYLDKDILLPAIGQGALGIECRSDDVELLELLSKVHNQAVANCVTAERTFLSAMDGSCQV 243

Query: 245 PIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           PIG YA    +GEI    L+  PDG++  R E     ++   +G +++  L   GA EI+
Sbjct: 244 PIGGYATNKENGEIEFTGLIMTPDGTK--RYEHTEVGKNPVDLGEAVSRVLKEQGAYEII 301

Query: 304 AEV 306
            ++
Sbjct: 302 KKL 304


>UniRef50_Q43316 Porphobilinogen deaminase, chloroplastic n=61 Tax=cellular
           organisms RepID=HEM3_ARATH
          Length = 382

 Score =  248 bits (633), Expect = 2e-64,   Method: Compositional matrix adjust.
 Identities = 138/300 (46%), Positives = 185/300 (61%), Gaps = 8/300 (2%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLV----VELVPMVTRGDVILDTPLAKVGGKG 60
           ++RI TR SPLAL QA+  ++KL   HP LV    + +  + T GD IL  PLA +GGKG
Sbjct: 74  IIRIGTRGSPLALAQAYETREKLKKKHPELVEDGAIHIEIIKTTGDKILSQPLADIGGKG 133

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LF KE++ AL+    DIAVHSMKDVP   P+   L     RED RDAF+     +L  LP
Sbjct: 134 LFTKEIDEALINGHIDIAVHSMKDVPTYLPEKTILPCNLPREDVRDAFICLTAATLAELP 193

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIR-SLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179
           AGS+VGT+SLRR+ Q+  + P L +  + RGNV TRLSKL  G+  A +LA+AGLKRL +
Sbjct: 194 AGSVVGTASLRRKSQILHKYPALHVEENFRGNVQTRLSKLQGGKVQATLLALAGLKRLSM 253

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
              + + L  +  LPAV QGA+GI CR DD +    LA+LNH ET L ++ ERA    L+
Sbjct: 254 TENVASILSLDEMLPAVAQGAIGIACRTDDDKMATYLASLNHEETRLAISCERAFLETLD 313

Query: 240 GGCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRG--APQDAEQMGISLAEELLN 296
           G C+ PI  YA    +G    R LV +PDG++++   R+G    +D  +MG    +ELL+
Sbjct: 314 GSCRTPIAGYASKDEEGNCIFRGLVASPDGTKVLETSRKGPYVYEDMVKMGKDAGQELLS 373


>UniRef50_Q2S2A6 Porphobilinogen deaminase n=1 Tax=Salinibacter ruber DSM 13855
           RepID=Q2S2A6_SALRD
          Length = 323

 Score =  248 bits (632), Expect = 2e-64,   Method: Compositional matrix adjust.
 Identities = 145/308 (47%), Positives = 196/308 (63%), Gaps = 5/308 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           + + L + TR S LAL QA+ V+ +L A+  G  VEL  + TRGD   DTP++++G + +
Sbjct: 3   ISDPLVLGTRGSELALRQANVVRSRLEAA--GHRVELETITTRGDEATDTPISEIGDEAV 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN-NYDS-LDAL 119
           F KEL+ ALL+   D+AVHS+KD+P   P GL L  I EREDPRDAFV++ ++D  L  L
Sbjct: 61  FTKELDRALLQGGVDLAVHSLKDIPSTVPSGLALAAIGEREDPRDAFVAHPSFDGHLHDL 120

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179
           P G+ V T+SLRR  QL   R DL +  +RGNV TRL KL   ++  ++LAVAGL RLGL
Sbjct: 121 PEGATVATASLRRTAQLLTWRSDLEVVPVRGNVDTRLEKLGESDWTGMVLAVAGLVRLGL 180

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELL-AALNHHETALRVTAERAMNTRL 238
              IR  + P + +PAVGQGA+GI CR D    R+LL   L+H  +     AERA   ++
Sbjct: 181 SLHIRDRIDPSLIVPAVGQGALGIACREDQDALRDLLRETLHHAPSGHAANAERAFLKKV 240

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
            GGCQVP+G++A + DG + L A + A DGS+  R ERR AP+D   +G  LA +LL  G
Sbjct: 241 GGGCQVPLGAWAHIDDGTLVLDACIAALDGSEHYRDERRCAPEDGAAVGRKLAADLLAMG 300

Query: 299 AREILAEV 306
              IL +V
Sbjct: 301 GDHILDDV 308


>UniRef50_P08397 Porphobilinogen deaminase n=59 Tax=Chordata RepID=HEM3_HUMAN
          Length = 361

 Score =  244 bits (624), Expect = 2e-63,   Method: Compositional matrix adjust.
 Identities = 145/332 (43%), Positives = 192/332 (57%), Gaps = 33/332 (9%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           V+R+ TR+S LA  Q   V   L AS+PGL  E++ M T GD ILDT L+K+G K LF K
Sbjct: 20  VIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTK 79

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLDALPA 121
           ELE AL +N  D+ VHS+KD+P   P G  +  IC+RE+P DA V +      +L+ LP 
Sbjct: 80  ELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPE 139

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD-NGEYDAIILAVAGLKRLGLE 180
            S+VGTSSLRR  QL  + P L  RS+RGN+ TRL KLD   E+ AIILA AGL+R+G  
Sbjct: 140 KSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQEFSAIILATAGLQRMGWH 199

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
           +R+   L PE  + AVGQGA+G+E R  D    +L+  L+  ET LR  AERA    LEG
Sbjct: 200 NRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEG 259

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIR----------GERRGAPQD-------- 282
           GC VP+  +  + DG+++L   V + DGS  I+           +    P+D        
Sbjct: 260 GCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIHVPAQHEDGPEDDPQLVGIT 319

Query: 283 -----------AEQMGISLAEELLNNGAREIL 303
                      A+ +GISLA  LL+ GA+ IL
Sbjct: 320 ARNIPRGPQLAAQNLGISLANLLLSKGAKNIL 351


>UniRef50_C3XEZ5 Porphobilinogen deaminase n=3 Tax=Campylobacterales
           RepID=C3XEZ5_9HELI
          Length = 328

 Score =  244 bits (623), Expect = 3e-63,   Method: Compositional matrix adjust.
 Identities = 147/311 (47%), Positives = 190/311 (61%), Gaps = 12/311 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L + TR S LALWQA+++K+KL     G  V L  + T+GD ILD PLAK+GGKGLF KE
Sbjct: 15  LVLGTRGSLLALWQANHIKEKL--ESLGFQVVLKTIKTKGDKILDAPLAKIGGKGLFTKE 72

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           LE  LL    D AVHS+KDVP+  P  L LV+I +RED RD FVS  Y  + +LP G+ V
Sbjct: 73  LENELLSGGIDFAVHSLKDVPIAIPPELMLVSITQREDARDCFVSEKYADIASLPQGAKV 132

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GT+SLRR  QL   R DL  +SLRGNV TRL KL  GE+DAIILA AGL RL L+  I  
Sbjct: 133 GTTSLRRSMQLKRIRQDLDTQSLRGNVQTRLEKLRKGEFDAIILASAGLNRLDLKDDIGF 192

Query: 186 ALPPEIS--LPAVGQGAVGIECR-------LDDSRTRELLAALNHHETALRVTAERAMNT 236
               +I+  +PA+GQG++GIECR         D    ++L +L+  ++AL    ERA   
Sbjct: 193 ISHLQINQFIPAMGQGSLGIECRDPKYSPDFRDQAIMKVLESLHDSKSALCCNIERAFIQ 252

Query: 237 RLEGGCQVPIGSYAELIDG-EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295
            L GGCQ PIG +A+++D  EI ++ +VG  D S+++   R     + E     +   L 
Sbjct: 253 LLGGGCQSPIGIHAQILDSKEIEIQCVVGNLDASKVLTETRVCNKGEVEYALQDMINTLK 312

Query: 296 NNGAREILAEV 306
            NG  EIL EV
Sbjct: 313 KNGVMEILEEV 323


>UniRef50_Q2LQU2 Porphobilinogen deaminase n=1 Tax=Syntrophus aciditrophicus SB
           RepID=HEM3_SYNAS
          Length = 306

 Score =  244 bits (622), Expect = 4e-63,   Method: Compositional matrix adjust.
 Identities = 131/304 (43%), Positives = 186/304 (61%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           ++I TR S LAL Q   +  +L   +P + +E+V + T GD+  D PLAK+GGKGLF+KE
Sbjct: 1   MKIGTRGSALALTQTRQIAARLQGQYPEMHLEIVVIKTSGDIQKDVPLAKIGGKGLFIKE 60

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E ALL    D+AVHSMKD+P E P+GL +  +  REDPRD  +S      D LPAG+ +
Sbjct: 61  IEEALLAGTVDLAVHSMKDLPAELPEGLQIAAVPRREDPRDVLISGICREFDNLPAGARI 120

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GT SLRR  QL + RPDL I  LRGN+ TR+ K+     D +++A AG++R+G   ++  
Sbjct: 121 GTGSLRRSVQLRDWRPDLEIVPLRGNLDTRIRKVAQAALDGVVVAAAGIRRMGWAEKVTQ 180

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            +P E  LPAVGQG + +E R +D   +  LA L    T   VTAERA   RL GGC +P
Sbjct: 181 FIPTEKMLPAVGQGVLCLETREEDEDLKAGLAFLEDKRTRREVTAERAFLRRLGGGCTLP 240

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305
           + ++AE     + +R +VG+ +   +IR E  G+ + A  +G  LAE LL+ G R +L  
Sbjct: 241 VAAFAEQRGDVLTIRGMVGSLNERTMIRQEIYGSVEQAVDLGTELAERLLDGGGRILLEH 300

Query: 306 VYNG 309
           + +G
Sbjct: 301 LEDG 304


>UniRef50_Q54P93 Porphobilinogen deaminase n=1 Tax=Dictyostelium discoideum
           RepID=HEM3_DICDI
          Length = 325

 Score =  240 bits (613), Expect = 4e-62,   Method: Compositional matrix adjust.
 Identities = 132/311 (42%), Positives = 190/311 (61%), Gaps = 12/311 (3%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67
           I +R+S LA+ Q  +V+D++   +PG++VE+  M T GD +LD  L+K+G KGLF KELE
Sbjct: 12  IGSRKSQLAMLQTEWVRDRIQELNPGIIVEIKTMDTTGDKVLDVSLSKIGDKGLFTKELE 71

Query: 68  VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD-----SLDALPAG 122
             +L    D+AVHS+KD+P + P GL L  I +R +  DAF++N         L  LP G
Sbjct: 72  DMMLNGTIDLAVHSLKDIPTKLPDGLKLGAITKRYNTSDAFIANAKKHGKNCKLSELPQG 131

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--DNGEYDAIILAVAGLKRLGLE 180
           +++G+SSLRR  QL +  P L  + +RGN+ TR  KL  D+  YD +ILAVAGL+R+ L 
Sbjct: 132 AMIGSSSLRRVAQLKKAYPHLQFKDIRGNLNTRFKKLEDDSNGYDGMILAVAGLERMELT 191

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
             I   +P  ISL AVGQG++GIEC+  D   + +L  L H E+     AER+M   LEG
Sbjct: 192 DHISEIIPDSISLYAVGQGSLGIECKDGDDFIQSILNPLIHRESMYCCEAERSMLRDLEG 251

Query: 241 GCQVPIGSYAELI-----DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295
           GC VPIG   +L      D  + + A+V   DGS+ I  +  G      Q+G S+A++L+
Sbjct: 252 GCHVPIGVVTKLHNQSQPDETLEINAIVLNLDGSKYIESKIIGPSIQYYQLGKSIAQDLI 311

Query: 296 NNGAREILAEV 306
           N G+++IL+E 
Sbjct: 312 NKGSKDILSEF 322


>UniRef50_B2S842 Porphobilinogen deaminase n=38 Tax=Rhizobiales RepID=HEM3_BRUA1
          Length = 314

 Score =  236 bits (602), Expect = 7e-61,   Method: Compositional matrix adjust.
 Identities = 134/294 (45%), Positives = 170/294 (57%), Gaps = 2/294 (0%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           +  L+I TR S LAL QA+  +  L  +H  P   +E++PM T GD I D PL++VGGKG
Sbjct: 8   NGTLKIGTRGSKLALAQAYLTRRLLQEAHGLPEDAIEILPMSTAGDRIQDRPLSEVGGKG 67

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LF +E+E AL + R DIAVHS KD+P   P+GL L    EREDPRDAF+  +      LP
Sbjct: 68  LFTEEIEQALKDGRIDIAVHSTKDMPTALPEGLHLSVFLEREDPRDAFIGRSARRFMDLP 127

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ VG+SSLRRQ  +   RPD+ +   RGNV TRL KLD GE D   LA AGL+RLGL 
Sbjct: 128 QGATVGSSSLRRQALIRRLRPDIEVVMYRGNVDTRLRKLDAGEVDGTFLACAGLRRLGLA 187

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
             I   L P +  PA GQGA+GIE R+ D R   LLA L H ET + +  ERA    L+G
Sbjct: 188 DVITDVLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERAFLGALDG 247

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
            C+ PI   A +    +  R ++  PDG Q       G   DA  +G   A  +
Sbjct: 248 SCRTPIAGLATVEGDRLSFRGMILTPDGRQAHEVTAEGVVSDAAALGTDAANRV 301


>UniRef50_A6WXJ2 Porphobilinogen deaminase n=56 Tax=cellular organisms
           RepID=HEM3_OCHA4
          Length = 314

 Score =  236 bits (602), Expect = 8e-61,   Method: Compositional matrix adjust.
 Identities = 132/294 (44%), Positives = 172/294 (58%), Gaps = 2/294 (0%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           +  L+I TR S LAL QA+  + +LM +H  P   +E++PM T GD I D  L+++GGKG
Sbjct: 8   NGTLKIGTRGSKLALAQAYETRRRLMEAHGLPEEAIEIIPMSTAGDRIQDRALSEIGGKG 67

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LF +E+E AL + R D+AVHS KD+P   P GL L    EREDPRDAF+      L  LP
Sbjct: 68  LFTEEIEQALTDGRIDLAVHSTKDMPTVLPDGLHLSVFLEREDPRDAFIGRTASRLLDLP 127

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ VG+SSLRRQ  +   RPD+ +   RGNV TRL KL+ GE D   LA AGL+RLGL 
Sbjct: 128 QGATVGSSSLRRQALIRRLRPDIQVVIFRGNVDTRLRKLEAGEVDGTFLACAGLRRLGLG 187

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
             I     PE   PA GQGA+GIE R+ D+R   LLA L H ET + +  ERA    L+G
Sbjct: 188 DVITDLADPESFPPAPGQGAIGIETRIGDTRIDTLLAPLAHRETGIALACERAFLAALDG 247

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
            C+ PI   A +    +    ++  PDGS+    +  G   +A  +G   AE L
Sbjct: 248 SCRTPIAGLATVNGDTVSFHGMILKPDGSEAHEIKTEGPASNAAAIGTEAAEHL 301


>UniRef50_A6GB01 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=A6GB01_9DELT
          Length = 322

 Score =  231 bits (588), Expect = 3e-59,   Method: Compositional matrix adjust.
 Identities = 140/304 (46%), Positives = 182/304 (59%), Gaps = 6/304 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           LR+ TR S LALWQA+ ++D+L+A+    GL VELV +VT+GD + D PL +VGG GLFV
Sbjct: 11  LRLGTRGSALALWQANMIRDRLLAAWGAQGLEVELVRVVTKGDRVTDRPLNQVGGMGLFV 70

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS--NNYDSLDALPA 121
           K LE  LL    D AVHSMKD+P   P+GL L +  ER DPRDAF++      +L  LPA
Sbjct: 71  KGLEDKLLAGEIDFAVHSMKDMPGTLPEGLTLASTPERADPRDAFLAAPGRDVTLATLPA 130

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           GS +GTSSLRR        P L I  +RGNV TR+ K+  GE DA++LA AGL RLG   
Sbjct: 131 GSRLGTSSLRRGALAKRINPGLEIVPIRGNVPTRMGKIAEGEVDAVLLAAAGLDRLGKGE 190

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
            I   L P+  +PA  QG + IE R  D+    L   L H  T++   AER+    L+GG
Sbjct: 191 AITERLDPDAFMPAACQGVLAIELRAADTDIAALFEPLGHGPTSIVAAAERSYLATLQGG 250

Query: 242 CQVPIGSYAELI-DG-EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
           CQVP+  +A L  DG  + +  LV  PDGS +   E  G   DA Q+G  +A E+L  G 
Sbjct: 251 CQVPLACHARLSEDGRRVRVEGLVVEPDGSTVYASEAEGPVADAAQLGAGVAREVLAAGG 310

Query: 300 REIL 303
           + ++
Sbjct: 311 QGVI 314


>UniRef50_A3ZKX4 Porphobilinogen deaminase n=1 Tax=Blastopirellula marina DSM 3645
           RepID=A3ZKX4_9PLAN
          Length = 308

 Score =  231 bits (588), Expect = 4e-59,   Method: Compositional matrix adjust.
 Identities = 134/301 (44%), Positives = 185/301 (61%), Gaps = 5/301 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR S LA WQA++V D+L A   G  VE++ + T+GDV    PL  +GG+G+F  E
Sbjct: 4   IRIGTRGSQLAQWQANWVADQLRAV--GTDVEIIHIATQGDVT-QGPLDLIGGRGVFTTE 60

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           ++ ALL+NR D+AVHS+KD+P E   GL L  +  R    D  +++    +  LP  SI+
Sbjct: 61  IQAALLDNRIDVAVHSLKDLPTEAVVGLRLAAVPARGADGDVLITSKASDVLGLPQESII 120

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GT S+RR+ QL   R D  IR +RGN+ TRL KLD+G YDAIILA AGL+RL L  RIR 
Sbjct: 121 GTGSMRRKAQLLHLRRDFQIRDIRGNLDTRLRKLDDGLYDAIILAEAGLRRLELIERIRH 180

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            +P    LPAVGQGA+G+E R  DS T  +LA LNH ++   V AER+M   L GGC  P
Sbjct: 181 VIPKAQMLPAVGQGALGLEIRERDSATAAMLAPLNHEDSHYSVLAERSMLRNLRGGCLAP 240

Query: 246 IGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           +G++  +  I   ++L  +V + DG   +     G P  AE +G  +A++L   GA  ++
Sbjct: 241 VGAWGRIDPIKQLLFLDGVVVSGDGHHKVTASACGPPNRAEDIGRQVADQLAIQGAERLI 300

Query: 304 A 304
           A
Sbjct: 301 A 301


>UniRef50_C8WIZ2 Porphobilinogen deaminase n=2 Tax=Coriobacteriaceae
           RepID=C8WIZ2_EGGLE
          Length = 327

 Score =  230 bits (586), Expect = 5e-59,   Method: Compositional matrix adjust.
 Identities = 138/314 (43%), Positives = 183/314 (58%), Gaps = 13/314 (4%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR S LALWQAH+V D L A+ PG+ V +  + T+GD IL   L+K+G KGLF KE
Sbjct: 4   MRIGTRGSKLALWQAHHVADLLRAASPGMDVSVEVVKTKGDRILGVALSKIGDKGLFTKE 63

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           LE AL + R D+ VHSMKDVP   P+GL L     R D RD  V+ +  +   LPAGS V
Sbjct: 64  LEQALFDGRVDVCVHSMKDVPTALPEGLALAGCLIRADARDVLVAASGTTFAGLPAGSRV 123

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GT +LRR  QL   R DL    +RGN+ TR++K+ +G  DA++LA AG++R+G  + +  
Sbjct: 124 GTGALRRLSQLRAVRDDLDYVEVRGNLDTRIAKVRDGALDAVVLAAAGIERMGWSAEVAE 183

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
           A   +  +PAVGQGA+G+E R DD RT    A +    T   V AER +   L+GGCQVP
Sbjct: 184 AFSVDTVVPAVGQGAIGLEVRADDERTARACAQVRCAATDACVAAERHVMRALDGGCQVP 243

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ-------------DAEQMGISLAE 292
           IG+YA   +G + L A VG+ DGS ++R     A Q             +A  +     E
Sbjct: 244 IGAYARYEEGLLVLDAFVGSLDGSHVLRSRLSAASQPPNDTDAVEAAVREARALAQRAVE 303

Query: 293 ELLNNGAREILAEV 306
           E    GAR +L  V
Sbjct: 304 EFEAQGARAVLDAV 317


>UniRef50_UPI0000583C22 PREDICTED: hypothetical protein n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000583C22
          Length = 324

 Score =  229 bits (584), Expect = 1e-58,   Method: Compositional matrix adjust.
 Identities = 131/313 (41%), Positives = 185/313 (59%), Gaps = 21/313 (6%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           ++R+ +R+S LA+ Q ++V + L   HP    ++V M T GD I D PLA +G   LF K
Sbjct: 7   IVRVGSRKSELAMIQTNHVVEMLQKVHPETEFKIVTMETIGDHIQDKPLASIGESNLFTK 66

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLDALPA 121
           ELE AL  +  D+ VHS+KD+P   P  + +  ICEREDP DA V +      S++ +  
Sbjct: 67  ELEKALALDEVDMLVHSLKDMPSRLPSNMAIGAICEREDPHDALVLHKKLTGISIETMKE 126

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-YDAIILAVAGLKRLGLE 180
           GS++GTSS+RR  QL  + P L+ + +RGN+ TRL KLD G+ YD ++LAVAG+ R+G E
Sbjct: 127 GSVLGTSSVRRVAQLKRKFPHLVFKDVRGNLNTRLRKLDEGQVYDGLVLAVAGMMRMGWE 186

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            RI   L P+I   +V QGA+GIE +  + R  ELL  LNH  T +R  AER +   LEG
Sbjct: 187 HRISQILKPDICKYSVSQGALGIEIKTKNRRMHELLRQLNHVPTLIRCIAERGLLKTLEG 246

Query: 241 GCQVPIGSYAEL----------IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISL 290
           GC  P+  ++EL           + E+ L + V AP  SQ        A Q+AE +G+S+
Sbjct: 247 GCSAPVAVHSELEENRHSLDAETNEEMKLFSSVIAPWVSQ-------HAMQEAEALGVSV 299

Query: 291 AEELLNNGAREIL 303
           A+ L + GA  IL
Sbjct: 300 AKGLFDKGAGPIL 312


>UniRef50_A7BMK1 Porphobilinogen deaminase n=1 Tax=Beggiatoa sp. SS
           RepID=A7BMK1_9GAMM
          Length = 211

 Score =  228 bits (581), Expect = 2e-58,   Method: Compositional matrix adjust.
 Identities = 124/209 (59%), Positives = 149/209 (71%), Gaps = 1/209 (0%)

Query: 101 REDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD 160
           RE+P DAFVSN Y +L ALP G+IVGTSSLRRQ QL   RPDL IRSLRGNVGTRLSKLD
Sbjct: 3   REEPFDAFVSNTYATLAALPEGAIVGTSSLRRQSQLLAHRPDLQIRSLRGNVGTRLSKLD 62

Query: 161 NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALN 220
           NG+YDAI+LA  GLKRLGL  RIR  +   I LPA+GQGA+GIECR DD  TR+ +  LN
Sbjct: 63  NGDYDAIVLAAVGLKRLGLVERIREIIDSTIMLPAIGQGAIGIECRQDDLETRQHIDNLN 122

Query: 221 HHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGA 279
             +T   V AERA+N  LEGGCQVPI  YAE+   E + +R LVG  +G  I+R   +GA
Sbjct: 123 DPDTQDCVIAERALNESLEGGCQVPIAGYAEIQSSENLTMRGLVGDIEGQHILRHNLQGA 182

Query: 280 PQDAEQMGISLAEELLNNGAREILAEVYN 308
              A ++G SLA+ LL  GA +IL ++ +
Sbjct: 183 RHLAAELGKSLAKVLLTQGAAQILEKLKD 211


>UniRef50_C1ZK04 Porphobilinogen deaminase n=1 Tax=Planctomyces limnophilus DSM 3776
           RepID=C1ZK04_PLALI
          Length = 318

 Score =  228 bits (581), Expect = 2e-58,   Method: Compositional matrix adjust.
 Identities = 140/315 (44%), Positives = 182/315 (57%), Gaps = 16/315 (5%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           VLRIATR S LALWQA++V D L +  P L VELV + T GD +   PL + GG+G+F +
Sbjct: 3   VLRIATRASQLALWQANFVADSLRSLDPELTVELVHVTTTGDRVQGEPLRQFGGQGVFTR 62

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV----SNNYDSLDALP 120
           E++ ALLE RADIAVHS+KD+P     GL L  +  R    DA +     +   SL  LP
Sbjct: 63  EVQAALLEGRADIAVHSLKDLPTVPTAGLELAAVPARAPVADALLLPTGHSGPASLAMLP 122

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ +GT S RRQ QL   RPDL+   +RGN+ TR+ KLD GEY+ +ILAVAGL RLG  
Sbjct: 123 RGARIGTGSPRRQAQLLRIRPDLVCSEVRGNLDTRIRKLDAGEYEGLILAVAGLSRLGWS 182

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            RI   L P    PA GQGA+G+ECR  D  T   ++ L   +T L V AERA+   LE 
Sbjct: 183 DRISLILAPPTMFPAAGQGALGLECRHGDEATIRWVSQLEDRQTRLAVDAERAVLRTLEA 242

Query: 241 GCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERR-----------GAPQDAEQMGI 288
           GC  P+G++A     E + L A++ APDGS+ +                 A   A ++G 
Sbjct: 243 GCHAPVGTWASWKSPETLHLEAILIAPDGSETLAAASSMQGPLSQYGSGNALDAAHELGA 302

Query: 289 SLAEELLNNGAREIL 303
           ++A  LL  GA   L
Sbjct: 303 NVAHLLLKQGASRYL 317


>UniRef50_C1AA38 Porphobilinogen deaminase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1AA38_GEMAT
          Length = 309

 Score =  227 bits (579), Expect = 4e-58,   Method: Compositional matrix adjust.
 Identities = 154/313 (49%), Positives = 189/313 (60%), Gaps = 12/313 (3%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M+   +RI TR S LAL QA  V  +L A   G+  ELV   T GD ILD PL+ +G KG
Sbjct: 1   MMTVPVRIGTRSSELALRQARQVAAQLDAR--GVPSELVEYTTLGDRILDRPLSAIGEKG 58

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLD 117
           LF  ELE  LL  R D AVHS+KD+P   PQG+ +V + EREDPRDA V     +  SLD
Sbjct: 59  LFTAELEADLLAGRIDCAVHSLKDLPTADPQGIIVVALLEREDPRDALVVRAGVDAHSLD 118

Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177
            LP G+ VGTSSLRR+ QL   R DL +  LRGNVGTRL KLD G+ DA +LA AGL RL
Sbjct: 119 TLPEGARVGTSSLRRRAQLQALRSDLEVCELRGNVGTRLRKLDEGQVDAALLAAAGLHRL 178

Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237
           GL  RI A L     L A GQGA+ ++ R DD      L++L+H  T + VTAERA+   
Sbjct: 179 GLADRIVAYLDAPEWLSAPGQGAIAVQGRADDEALLSTLSSLDHAPTRVAVTAERALLAA 238

Query: 238 LEGGCQVPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQ---MGISLAEE 293
           LEGGCQVPIG+   E  +    L A++ + DGS  +RG   G P D       GI LA +
Sbjct: 239 LEGGCQVPIGAAVLEEPEYGTILHAVIVSLDGSSAVRG---GYPVDHANPAASGIELARQ 295

Query: 294 LLNNGAREILAEV 306
           L   G  +IL+E+
Sbjct: 296 LRAAGGAQILSEI 308


>UniRef50_UPI00017922DC PREDICTED: similar to porphobilinogen deaminase n=1
           Tax=Acyrthosiphon pisum RepID=UPI00017922DC
          Length = 377

 Score =  225 bits (574), Expect = 1e-57,   Method: Compositional matrix adjust.
 Identities = 122/276 (44%), Positives = 163/276 (59%), Gaps = 22/276 (7%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             +R+ +R+S LAL Q  +V  +L   HP +  E+V M T GD +LD PL K+G K LF 
Sbjct: 7   KTIRVGSRKSELALIQTKFVISQLKELHPEIEFEIVSMTTMGDRVLDKPLPKIGEKSLFT 66

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV----SNNYDSLDAL 119
           K+LEVALL    D  VHS+KD+P     G  +  I +R+DPRDA V       Y  LD+L
Sbjct: 67  KDLEVALLSGTVDFIVHSLKDLPTVMEIGTTIGAILKRDDPRDALVLRDDCKEY-QLDSL 125

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD---------NGEYDAIILA 170
           P+ S +GTSSLRR  QL  + P+L +  +RGN+ TRL KLD         N  Y  IILA
Sbjct: 126 PSKSFIGTSSLRRTAQLKRKFPNLQVSDVRGNLNTRLKKLDSSQSTGDNTNTNYSGIILA 185

Query: 171 VAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTA 230
           +AG++R+G E R+   +  ++ L AVGQGA+ +ECRL D    E+L  L+H+ET L+V A
Sbjct: 186 LAGIQRMGWEKRVSQIIDSDVMLYAVGQGALAVECRLGDDYILEMLEPLHHYETVLQVVA 245

Query: 231 ERAMNTRLEGGCQVPIG--------SYAELIDGEIW 258
           ER   TRL GGC  P+G          A  +DG +W
Sbjct: 246 ERGFLTRLGGGCSAPVGIRSTVCLTKNAMSLDGAVW 281


>UniRef50_Q1J288 Porphobilinogen deaminase n=5 Tax=Deinococci RepID=HEM3_DEIGD
          Length = 309

 Score =  224 bits (570), Expect = 4e-57,   Method: Compositional matrix adjust.
 Identities = 131/304 (43%), Positives = 183/304 (60%), Gaps = 5/304 (1%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGD---VILDTPLAKVGGKGLFVK 64
           + TR S LAL Q  +V  +L    P     +  + T+GD     L + LA+ G KG +VK
Sbjct: 6   VGTRGSALALAQTRWVVARLKEEWPDTDFRIQTISTKGDRDRAALQS-LAQKGDKGFWVK 64

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALPAGS 123
           E+E ALL  R DIAVHS+KD+P E P+GL + +I +R D RD  +  +    L+ LP+G+
Sbjct: 65  EIEDALLAGRIDIAVHSLKDLPTEQPEGLEIASIPKRVDARDVLIGKDGMKRLEDLPSGA 124

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            VGTSS+RR+  L   RPDL I  LRGN+ TRL+ L   +YDAI+LA AGL R  +  RI
Sbjct: 125 RVGTSSVRRKAFLRAYRPDLQILDLRGNIDTRLAALGTPDYDAIVLAAAGLIRTEMRHRI 184

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              + P++ LPA GQGA+ +E R DD  + E++ A++ H T  RVTAER     L  GC 
Sbjct: 185 DEFIDPDLLLPAPGQGALALETRADDDLSIEVVYAIHDHATDDRVTAEREFLAGLGAGCM 244

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
            P+G++A L DG + L   VGA DGSQ+IR    G P +   +G  LA ++L  GA++++
Sbjct: 245 APVGAHATLKDGVLTLEGWVGALDGSQVIRATTSGDPAECADLGAELAADMLGQGAQQLI 304

Query: 304 AEVY 307
              +
Sbjct: 305 EAAH 308


>UniRef50_A8U3E9 Porphobilinogen deaminase n=1 Tax=alpha proteobacterium BAL199
           RepID=A8U3E9_9PROT
          Length = 321

 Score =  222 bits (566), Expect = 1e-56,   Method: Compositional matrix adjust.
 Identities = 131/306 (42%), Positives = 178/306 (58%), Gaps = 7/306 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLV--VELVPMVTRGDVILDTPLAKVGGKGLFV 63
           L + +R SPLAL Q H V+D+L A+ P L   + +  + T GD + D PLA++GGKGLF+
Sbjct: 15  LTLGSRGSPLALRQTHEVRDRLAAAWPELAGAIAVQEIRTTGDAVRDRPLAEIGGKGLFI 74

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KE+E AL+  + D AVHSMKD+         LV +  REDPRDA++S   D +D LP+G+
Sbjct: 75  KEIEQALMAGQIDAAVHSMKDMETTIAPASVLVAVLPREDPRDAWLSPIADRVDDLPSGA 134

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            +GT+S+RR  Q+  RRPDL +   RGNV TRL KL  GE     LA AGL RLG+  + 
Sbjct: 135 KIGTASVRRAAQVLNRRPDLQVVLFRGNVDTRLRKLAEGEVAGTFLAAAGLSRLGMLDKA 194

Query: 184 RAALPPEISLPAVGQGAVGIECR-----LDDSRTRELLAALNHHETALRVTAERAMNTRL 238
              L  +  LPAV QGA+G++CR       D+  R  L+ L+   + LRVTAERAM   L
Sbjct: 195 TRILEVDEMLPAVSQGAIGVQCRDGEASARDAEIRNWLSILDDRPSRLRVTAERAMLATL 254

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
           +G C+ PI  +A L    + L  +V + DG          A  D E +G ++ E +L  G
Sbjct: 255 DGSCRTPIAGHATLGGARLTLSGMVFSLDGQSSHGAVDTSATDDPEALGRTVGEAILARG 314

Query: 299 AREILA 304
            R  LA
Sbjct: 315 GRNFLA 320


>UniRef50_A6DBT5 Porphobilinogen deaminase n=1 Tax=Caminibacter mediatlanticus TB-2
           RepID=A6DBT5_9PROT
          Length = 295

 Score =  222 bits (566), Expect = 1e-56,   Method: Compositional matrix adjust.
 Identities = 132/293 (45%), Positives = 177/293 (60%), Gaps = 8/293 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L IATR S LALWQA +VK +L   + G  V+L  + T GD ILD PLA +GGKGLF+KE
Sbjct: 3   LTIATRGSKLALWQAEWVKKRL--ENLGHEVDLKIVTTTGDKILDKPLASIGGKGLFIKE 60

Query: 66  LEVALLENRADIAVHSMKDVPVEF-PQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           +E ALL   A IAVHS+KD P E+  +   L  + +RE   D F+S  +++L  LP  ++
Sbjct: 61  VEEALLRGEAQIAVHSLKDFPTEYNKEHFTLAAVPKREAVEDVFLSETFETLAELPHNAV 120

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL--ESR 182
           VGTSS+RR  QL   R DL+I  LRGNV TR++KL  GEYDAIILA AG+KRL L  E +
Sbjct: 121 VGTSSIRRAMQLKAFREDLVISDLRGNVDTRINKLKKGEYDAIILAYAGVKRLNLIKEVK 180

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
               L  +I +PA+GQGA+GIE  + D +  E +  LN   T + VT ER     L  GC
Sbjct: 181 YFEILDTDIMIPAMGQGALGIET-IKDEKVIEAVKPLNDLWTKIEVTIERDFIDELNLGC 239

Query: 243 QVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
             P+G  A+ ++D  I ++A +     +++I+ E      + E  G   AEE 
Sbjct: 240 HAPVGVNAKIMVDDSIKIKAAI-LDKNNKVIKKEMVVPFDEWENAGREFAEEF 291


>UniRef50_A3CL78 Porphobilinogen deaminase n=1 Tax=Streptococcus sanguinis SK36
           RepID=HEM3_STRSV
          Length = 306

 Score =  219 bits (559), Expect = 7e-56,   Method: Compositional matrix adjust.
 Identities = 126/300 (42%), Positives = 180/300 (60%), Gaps = 7/300 (2%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
            V+++ TR+S LA+ Q   + D+L A HP     LVP  T+GD +    L ++GGKG+FV
Sbjct: 2   KVIKVGTRKSKLAMTQTQQLVDQLKALHPERDFVLVPYTTKGDRLTHVSLQEIGGKGVFV 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALPAG 122
           KE+E ALL    ++AVHS+KD+P +  +G  L  I +RED RD  +      +L  LP G
Sbjct: 62  KEIERALLAGEINMAVHSLKDMPAKLAEGCALGAISQREDVRDCLIFRQAGQTLADLPKG 121

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           S++GTSS+RRQ QL  +RPDL  + LRGN+ TR+ KL+ GEYDAI+LA+AGLKRLG   +
Sbjct: 122 SLIGTSSIRRQVQLQAQRPDLAFKPLRGNIDTRIKKLEEGEYDAIVLAMAGLKRLGWLDQ 181

Query: 183 IRAALPP---EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
            R  + P    + LPA+ QGA+ +ECR +D     LLAA+   +TA  V  ERA+  ++ 
Sbjct: 182 SRLHIQPLETSLCLPAISQGALAVECREEDEELLSLLAAVQDEKTAAEVAVERAVLAQMN 241

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
             C  PI ++A+       L A++   DG Q I    +G  QD +Q+      +L + GA
Sbjct: 242 ADCTFPIAAFAQKNGQGYQLEAMLAKEDG-QCIFVSLQG--QDGQQLAEQAVRQLADKGA 298


>UniRef50_C1F251 Hydroxymethylbilane synthase n=1 Tax=Acidobacterium capsulatum ATCC
           51196 RepID=C1F251_ACIC5
          Length = 312

 Score =  219 bits (559), Expect = 7e-56,   Method: Compositional matrix adjust.
 Identities = 124/255 (48%), Positives = 158/255 (61%), Gaps = 6/255 (2%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKV----GGKG 60
           ++RI +R S LALWQA+++  +L      + +E++   T GD +     AKV    GGKG
Sbjct: 1   MMRIGSRGSQLALWQANHIAARLRTLGHEVTIEIIR--TTGDALQHVTFAKVSTELGGKG 58

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           +F KE+E AL E R D+AVHS+KD+P +      L  I ER DPRDA +S  Y SL +LP
Sbjct: 59  IFTKEIEEALREGRIDLAVHSLKDLPTDLDPAFTLAAIPERVDPRDALLSARYTSLASLP 118

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ VGTSS RR+ QL   R DL  +  RGNV TR+ K+  G+ DAIILA AGL+RLGL 
Sbjct: 119 HGACVGTSSERRRAQLLVHRSDLRFQEFRGNVDTRIRKMVEGQADAIILASAGLERLGLT 178

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
              R  L PEI  PA GQGA+ IE R DD+ T  +LA+L+H  T   VTAER     L G
Sbjct: 179 EYRRECLAPEILCPAAGQGALAIETRADDAETLAILASLDHSATRYAVTAERTALASLGG 238

Query: 241 GCQVPIGSYAELIDG 255
           GCQVPIG +   + G
Sbjct: 239 GCQVPIGIHCAPVPG 253


>UniRef50_O94048 Porphobilinogen deaminase n=53 Tax=Saccharomyceta RepID=HEM3_CANAL
          Length = 340

 Score =  217 bits (552), Expect = 5e-55,   Method: Compositional matrix adjust.
 Identities = 132/318 (41%), Positives = 189/318 (59%), Gaps = 17/318 (5%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           N ++I  R+S LA+ Q+  VK  +  + P L   ++ + T GD +   PL   GGK L+ 
Sbjct: 12  NHVQIGGRKSKLAVVQSEIVKKVIEDTFPNLSCSILALSTLGDKVQTQPLYTFGGKSLWT 71

Query: 64  KELEVALLEN-----RADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDS 115
           KELE+ LL++     + D+ VHS+KD+P   P+   L  I +REDPRDA V    ++Y S
Sbjct: 72  KELEILLLDSVDEFPKLDLIVHSLKDMPTNLPEEFELGCIFQREDPRDAIVMKQGSSYKS 131

Query: 116 LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAG 173
           L  LPAG+IVGTSS+RR  QL +  P L   S+RGN+ TRL+KLD  N EY  +ILA AG
Sbjct: 132 LKDLPAGAIVGTSSIRRSSQLIKNYPHLRFESVRGNIQTRLNKLDQPNNEYCCLILASAG 191

Query: 174 LKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERA 233
           L RLGL  RI + L  +    AVGQGA+GIE R  D   + +L  +      +   AER+
Sbjct: 192 LIRLGLGHRITSYL--DDMYYAVGQGALGIEIRKGDDNIKSILKKIEDPIATICCLAERS 249

Query: 234 MNTRLEGGCQVPIGSYAELIDG--EIWLRALVGAPDGSQIIRGE---RRGAPQDAEQMGI 288
           +   LEGGC VP+G +++  +   E+ L+ ++ +PDG+  I  E   R    +D EQ+GI
Sbjct: 250 LMRYLEGGCSVPLGVHSDYNESKQELTLKGIIVSPDGTVSIEDEVIKRITCDEDCEQVGI 309

Query: 289 SLAEELLNNGAREILAEV 306
            L ++L   GA+EIL ++
Sbjct: 310 ELGDKLKAKGAKEILDKI 327


>UniRef50_C7NFP7 Hydroxymethylbilane synthase n=7 Tax=Actinomycetales
           RepID=C7NFP7_KYTSD
          Length = 358

 Score =  215 bits (548), Expect = 1e-54,   Method: Compositional matrix adjust.
 Identities = 126/268 (47%), Positives = 167/268 (62%), Gaps = 3/268 (1%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           V+R+ TR+S LA  Q+ +V D L A   G  VELV + T GDV    PL+++GG G+FV 
Sbjct: 15  VVRLGTRRSDLATTQSTHVADALRAR--GHEVELVLVTTEGDVN-RAPLSRIGGTGVFVS 71

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
            L  ALL    DIAVHS+KD+PV  PQ L +  + EREDPRDA V+ +  +L+ LPAG+ 
Sbjct: 72  ALRDALLAGEIDIAVHSLKDLPVAQPQELVIAAVPEREDPRDALVARDGLTLETLPAGAR 131

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGT S RR+ QL   RPDL +  LRGNV  RL+ +  GE DA++LA AGL+RLGL   + 
Sbjct: 132 VGTGSPRREAQLRVARPDLEVVDLRGNVPRRLATVAEGELDAVVLAGAGLRRLGLTEHVT 191

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L P++ +PA GQGA+ +ECR DD+ +  +L  L+H  T    TAERA+   LE GC  
Sbjct: 192 QWLEPQVMVPAPGQGALAVECRSDDAESIAMLEPLDHLPTRTATTAERAVLGTLEAGCSA 251

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQII 272
           PIG+ A      + L    G  DGS+ +
Sbjct: 252 PIGALARHDGARVDLMTFAGPRDGSRAL 279


>UniRef50_Q0TQG4 Porphobilinogen deaminase n=32 Tax=Clostridium RepID=HEM3_CLOP1
          Length = 291

 Score =  214 bits (545), Expect = 3e-54,   Method: Compositional matrix adjust.
 Identities = 129/290 (44%), Positives = 172/290 (59%), Gaps = 4/290 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L IATR+S LA  Q   V + L+     +  + + ++T GD  LD  L K+GGKGLFVKE
Sbjct: 3   LIIATRKSKLAQVQTEKVME-LLKEKENVDSKKLLVMTEGDRRLDVSLNKIGGKGLFVKE 61

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E+ALL   A  AVHSMKDVP E P    LV + ERED RDAFVS N  +L  L  G+ +
Sbjct: 62  IELALLNKEAHGAVHSMKDVPFELPSEFELVAMPEREDIRDAFVSLNGSTLSNLRKGARI 121

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS+RR  QL   R DL I  +RGNV TR+ K+     D IILA AGLKRLG+E  I  
Sbjct: 122 GTSSIRRAEQLKLFRDDLEIVPIRGNVQTRIKKITEENLDGIILAAAGLKRLGMEDVISD 181

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
              P++ LPA+GQGA+GIEC L      +   AL+  E    V AER+    L GGC   
Sbjct: 182 YFDPKVFLPAIGQGALGIEC-LKGGEFNDYFKALDSKEVRTTVEAERSFMKVLNGGCHSL 240

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295
           IG+Y+E+ D ++++         ++I++ +  G  +D   +G  LAE++L
Sbjct: 241 IGAYSEVKDNDLYMIGTFTV--NNRIVKKDILGNKEDNILLGKKLAEKIL 288


>UniRef50_Q3YSA8 Porphobilinogen deaminase n=17 Tax=Rickettsiales RepID=HEM3_EHRCJ
          Length = 298

 Score =  214 bits (544), Expect = 4e-54,   Method: Compositional matrix adjust.
 Identities = 112/292 (38%), Positives = 177/292 (60%), Gaps = 3/292 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR S LAL Q   V + L    P + +++V + T GD+    P+  +GGKGLF+KE
Sbjct: 3   IRIGTRGSVLALAQTLEVTNLLNRYFPEINIQVVKIKTSGDINNKVPINTIGGKGLFIKE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E ALL  + D+AVHS+KD+P  +  GL +  + +R  P D FVS+ Y S+ +LP  + V
Sbjct: 63  IEEALLIGKVDLAVHSVKDIPAFYCDGLIIPCVLKRSSPYDVFVSSKYQSIKSLPINATV 122

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS+RR+ QL   RPDL +  +RGN+ TR+ K D GE+D I+LA AGL R+   + I+ 
Sbjct: 123 GTSSIRRKVQLNYLRPDLQVIPVRGNIDTRILKSDIGEFDGIVLAEAGLIRINKCNVIKE 182

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L  +I L AVGQGA+ ++CR DD      +  LN H++ + V AER+    + G C  P
Sbjct: 183 VLDSKIMLSAVGQGAICVQCRADDYNIINKIKVLNCHKSYVCVIAERSFLKTINGSCDTP 242

Query: 246 IGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
           + + A+ +D + I++  ++   +  +++  +      +AE+ GI + ++L+N
Sbjct: 243 LAALAQYVDSDTIYMSCMLS--NEKEMVFSDCYFKECNAEESGIDMGKKLIN 292


>UniRef50_B6FXV9 Putative uncharacterized protein n=1 Tax=Clostridium hiranonis DSM
           13275 RepID=B6FXV9_9CLOT
          Length = 299

 Score =  212 bits (540), Expect = 1e-53,   Method: Compositional matrix adjust.
 Identities = 116/298 (38%), Positives = 178/298 (59%), Gaps = 3/298 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +R+ TR S LAL Q ++  D+L    P +  E+  + T+GD IL   L K+G KGLFVKE
Sbjct: 3   IRVGTRGSNLALIQTNWAIDRLKEKFPEVEFEVKIIKTKGDKILHLSLDKIGDKGLFVKE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV-SNNYDSLDALPAGSI 124
           +E  LLE   D+AVHSMKD+P E  +GL    + +REDPRD  +     +S D LP G+ 
Sbjct: 63  IESQLLEGEIDLAVHSMKDMPAEVVEGLKFAAVPKREDPRDVIILREGLNSFDELPIGAT 122

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GT S RR+ QL  +RPDL I  +RGN+ TR+SK+++   D I+LA +G+ R  LE +I 
Sbjct: 123 IGTGSKRRKYQLLRKRPDLNIVPIRGNIETRISKIESENLDGIVLAASGVIRADLEEKIT 182

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             LP ++ +PA  QGA+ +E R +D    +++ A+    + ++  AER+    ++G C +
Sbjct: 183 EFLPVDLMIPAPAQGALALEIRENDEELEKMIDAIKDEISQIQTDAERSYLAGIDGSCHI 242

Query: 245 PIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           P+G+Y E +DGE + L  + G  DG +I      G   + +++G +LA+ +L     E
Sbjct: 243 PMGAYCE-VDGEKLTLTGIFGDEDGEKITVASLEGDRDNPKELGSNLAKLVLKKHREE 299


>UniRef50_C3PNS9 Porphobilinogen deaminase n=15 Tax=Rickettsia RepID=HEM3_RICAE
          Length = 351

 Score =  212 bits (540), Expect = 1e-53,   Method: Compositional matrix adjust.
 Identities = 108/256 (42%), Positives = 159/256 (62%), Gaps = 3/256 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           + N +RI TR+SPLAL   + V  ++    P +  E+VP++T GD+I + PL  +GGK L
Sbjct: 1   MTNSIRIGTRKSPLALIHTNLVIQQIKQFFPDINCEIVPIITSGDLIQNKPLYDIGGKAL 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F+KE+E ALL+ + D+AVHS+KDVP   P+ L +  + EREDPRD FV   Y S++ LP 
Sbjct: 61  FLKEIEQALLDKKIDLAVHSLKDVPGRIPEPLVIAAVLEREDPRDVFVCLKYKSIEELPQ 120

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
            +++G+S++RR+  + + RPDL +   RGNV +R+ KL  GE DA ILA  GLKRL + +
Sbjct: 121 NAVIGSSAVRRKAFIQKIRPDLKVTVFRGNVDSRIKKLMTGEVDATILAYTGLKRLEVFN 180

Query: 182 RIRAALPPEIS--LPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
                L  E S  LP +GQG + +E R DD+   E+   +NH  T   +  ERA    L+
Sbjct: 181 PEYCHL-IEYSQMLPCIGQGVIAVEIRKDDNAMLEICNQINHLPTFELIKPERAFLEYLD 239

Query: 240 GGCQVPIGSYAELIDG 255
             C+ PI +Y++ +D 
Sbjct: 240 ANCRTPIAAYSQYLDA 255


>UniRef50_Q180R9 Porphobilinogen deaminase n=11 Tax=Bacteria RepID=HEM3_CLOD6
          Length = 301

 Score =  212 bits (539), Expect = 1e-53,   Method: Compositional matrix adjust.
 Identities = 111/289 (38%), Positives = 172/289 (59%), Gaps = 1/289 (0%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67
           + TR S LAL Q  +V ++L   +P +  E+  + T+GD+I +  L K+G KGLFVKE+E
Sbjct: 5   VGTRGSNLALIQTEWVINELKKKYPEISFEIKIIKTKGDLIQNVSLDKIGDKGLFVKEIE 64

Query: 68  VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV-SNNYDSLDALPAGSIVG 126
             LL+ + DIAVHSMKD+P     GL      +REDPRD  +    Y +LD LP G+++G
Sbjct: 65  QQLLDGKIDIAVHSMKDMPSYLANGLKFAHTPKREDPRDVLILREGYKNLDDLPHGAVIG 124

Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAA 186
           T S RR+ QL ++RPDL I  +RGNV TR+ K+ +     I+LA +G+ R  L+ +I + 
Sbjct: 125 TGSKRRKFQLLKQRPDLNIVQVRGNVETRIRKIKDENMHGIVLAASGIIRANLQDKISSY 184

Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246
           LP ++ +PA  QGA+ IE R +DS    ++ +L    T +++ AER     + G C +P+
Sbjct: 185 LPVDVVIPAPAQGALAIEIRSNDSAIEGIVNSLKDENTEIQILAERGFLDGVNGSCHIPM 244

Query: 247 GSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295
            +Y E+I  +I L  L G  +G +++     G      ++G+ LA+ +L
Sbjct: 245 AAYCEIIQDKIHLTGLYGDSEGKKVVIKSIDGDISSPRELGLKLAKLVL 293


>UniRef50_A3VPD5 Porphobilinogen deaminase n=1 Tax=Parvularcula bermudensis HTCC2503
           RepID=A3VPD5_9PROT
          Length = 324

 Score =  211 bits (538), Expect = 2e-53,   Method: Compositional matrix adjust.
 Identities = 135/280 (48%), Positives = 180/280 (64%), Gaps = 12/280 (4%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELV---------PMVTRGDVILDTPLAKV 56
           LRIA+R+SPLA+ QA +V+D+L  +   L ++ V           VT GD +L+  LA +
Sbjct: 6   LRIASRRSPLAVAQALWVRDRLAEA---LGIDEVDRDAAFPHETFVTTGDRMLNPTLADI 62

Query: 57  GGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSL 116
           GGKGLF KE+E+ALL+ +ADIAVHSMKD+P + P GL L  +  REDPRDAFV+ +   L
Sbjct: 63  GGKGLFTKEIEIALLDGQADIAVHSMKDMPAQMPPGLVLAAVPVREDPRDAFVTLDGRPL 122

Query: 117 DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKR 176
           D +PAG+ +GTSS RR+ QLA  RPDL +  +RGNVGTRL KL  GE +   LA AGL+R
Sbjct: 123 DQMPAGARIGTSSTRRRAQLARLRPDLALVPMRGNVGTRLQKLAAGEAEGTFLAEAGLRR 182

Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236
           LG+    R AL P   LPA+GQGA+ ++ R  D  T    A +N+  TAL   AERA+ +
Sbjct: 183 LGMTDVKREALSPARMLPALGQGALCVQARSGDHETLSACAHINNRPTALAAAAERALIS 242

Query: 237 RLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER 276
            L+G C+ PIG  A      + L   +  PDG +++RGER
Sbjct: 243 GLDGSCKTPIGGLARQTGDSLILEGQILTPDGRRVLRGER 282


>UniRef50_Q5HBG1 Porphobilinogen deaminase n=2 Tax=Ehrlichia ruminantium
           RepID=Q5HBG1_EHRRW
          Length = 299

 Score =  211 bits (538), Expect = 2e-53,   Method: Compositional matrix adjust.
 Identities = 111/292 (38%), Positives = 177/292 (60%), Gaps = 3/292 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           + + TR S LA+ QA  VK  L    P + V++V +VT GD+     L+++GGKGLF+KE
Sbjct: 6   VYVGTRGSILAIAQAMEVKKLLYNYFPDINVQIVHIVTSGDINDKISLSEIGGKGLFLKE 65

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           LE ALL    D+AVHSMKDVP  +   L +  I +R  P D F+S+ Y SL +LP  +++
Sbjct: 66  LEEALLTGTIDLAVHSMKDVPAFYCDSLVIPCILKRSSPYDVFISSKYQSLRSLPDNAVI 125

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS+RR+ QL      + +  +RGNV TR+ KL+ G+YD IILA AGL R+     I+ 
Sbjct: 126 GTSSIRRKVQLMRLLSSVQVVPIRGNVDTRILKLEAGQYDGIILAKAGLMRINKTHVIKE 185

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L P++ L AVGQGA+GI+CR +D +  +++  LN  ++ + V AER+    + G C  P
Sbjct: 186 VLDPQVMLSAVGQGAIGIQCRANDYKMIDMIKILNCKKSYISVAAERSFMKTVNGSCDTP 245

Query: 246 IGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
           + + A+ ++ + +++  ++   +  + +  +      DAE  GI++  +L++
Sbjct: 246 LAALAKYVNSDTLYMSCMLSNEE--KTVFSDCYFNECDAEISGINMGNDLMD 295


>UniRef50_B3U3W9 Hydroxymethylbilane synthetase n=1 Tax=Oxyrrhis marina
           RepID=B3U3W9_OXYMA
          Length = 395

 Score =  209 bits (533), Expect = 7e-53,   Method: Compositional matrix adjust.
 Identities = 133/305 (43%), Positives = 173/305 (56%), Gaps = 7/305 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMAS-HPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           LRI TR SPLAL QA  V+ +       G  +++  + T GD ILD  LA VGGKGLF K
Sbjct: 76  LRIGTRGSPLALAQARDVESRAREQLQQGGEIDICVISTEGDRILDRALADVGGKGLFTK 135

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           EL+ ALL    D  VHSMKDVP     G  +V    RED RD F+S  Y +L  LP G++
Sbjct: 136 ELDRALLSGEVDCCVHSMKDVPTTVAPGTEIVAYLPREDTRDVFLSAKYATLADLPDGAV 195

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGT+SLRRQ Q+  ++ ++++ + RGNV TRL KL  G  D   LA AGLKRLG+ +   
Sbjct: 196 VGTASLRRQAQILAQK-NVVVTNFRGNVQTRLRKLAAGTVDCTFLAYAGLKRLGMLAEAT 254

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L     LPA+ QGAVGI+ R +D+  R  L+ L+H  T L V  ERA    L+G C+ 
Sbjct: 255 QVLEWSDMLPAIAQGAVGIQIRSNDAALRGTLSQLDHEPTRLAVETERAFLRALDGSCRT 314

Query: 245 PIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRG--APQDAEQMGISLAEELLNNGARE 301
           PI   A +  D  +  R  V + DG Q  R ER G   P D  ++G +L ++L      E
Sbjct: 315 PIAGQAWIGPDSRLAFRGQVLSADGKQ--RFERVGDCLPCDGPELGKTLGDDLRREAGEE 372

Query: 302 ILAEV 306
             AE+
Sbjct: 373 FFAEL 377


>UniRef50_A8MDU3 Probable porphobilinogen deaminase n=2 Tax=Thermoproteaceae
           RepID=HEM3_CALMQ
          Length = 305

 Score =  209 bits (533), Expect = 7e-53,   Method: Compositional matrix adjust.
 Identities = 124/302 (41%), Positives = 181/302 (59%), Gaps = 2/302 (0%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           ++RIATR S L+L Q   V D+++  +  +  +L+ + T GDV L  PL ++G KG+F +
Sbjct: 2   IIRIATRGSALSLKQTKIVMDRILEFNKDVEFKLIIVKTTGDVDLSKPLYEIGVKGIFER 61

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           E+  A+L   AD+AVHS+KD+P +    L LV    R++PRDA VS    ++D LP  SI
Sbjct: 62  EVNQAVLRGEADVAVHSLKDMPAQISNDLTLVMTPPRDNPRDALVSLRQYTVDTLPLNSI 121

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGTSSLRR+  L   R D+ ++ +RGNV TR+ KL+NGEYDA+I+A AGL+RL + + + 
Sbjct: 122 VGTSSLRRRGFLLSLRRDVTVKPIRGNVDTRIRKLNNGEYDALIMAAAGLERLSINANV- 180

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
           + + PE+  PA GQG +G+  R D     ++L   +  ET     AERA  +R+  GC V
Sbjct: 181 SEISPELMPPAPGQGIIGVVARRDRDDLIKVLRRSSDEETFKEAAAERAFLSRIGAGCHV 240

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304
           P+G  A L DG       V  PDG +      R   ++ E+ G   AE+LL N AR ++A
Sbjct: 241 PLGGLALLDDGYFDFTYGVVDPDGVEKFINSTRIDARNPEEAGRVAAEDLLRN-ARGLVA 299

Query: 305 EV 306
            +
Sbjct: 300 RL 301


>UniRef50_C4Z552 Porphobilinogen deaminase n=8 Tax=Bacteria RepID=HEM3_EUBE2
          Length = 295

 Score =  209 bits (531), Expect = 1e-52,   Method: Compositional matrix adjust.
 Identities = 121/284 (42%), Positives = 164/284 (57%), Gaps = 5/284 (1%)

Query: 7   RIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66
           RI TR S LAL Q+ YVK ++  ++P    ELV + T GD + D PLA +G KG FVKE+
Sbjct: 4   RIGTRGSKLALVQSEYVKRRMEEAYPEDTFELVIIKTTGDKVTDKPLAAIGTKGFFVKEI 63

Query: 67  EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126
           E ALL    D+AVHSMKD+P E   GL      +RED RD  +     S   LP+G+++G
Sbjct: 64  EEALLSGSIDMAVHSMKDMPAECAAGLTFAKAWKREDCRDVLILKTAGSFSELPSGAVIG 123

Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY--DAIILAVAGLKRLGLESRIR 184
           T SLRR CQLA  RPD+   ++RGNV TR++KL +  Y  D I+LA AGL RLG  S I 
Sbjct: 124 TGSLRRACQLAMLRPDIQFTAIRGNVDTRINKLMDDSYGLDGIVLAAAGLNRLGRSSEIT 183

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L PE+ +PA  QG + IE    ++   + + AL+   +     AER       GGC  
Sbjct: 184 EYLDPEVVIPAPAQGVLAIETAEVNTELLDKINALSDDNSDREAVAERTFLRLTGGGCHA 243

Query: 245 PIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMG 287
           P+G++    D G++ +  L G  D S+I+R E  G   D+E +G
Sbjct: 244 PVGAHCVTKDNGDLRMVVLFGNDDCSRILRIEVTGT--DSEAVG 285


>UniRef50_A5CDH4 Porphobilinogen deaminase n=2 Tax=Orientia tsutsugamushi
           RepID=HEM3_ORITB
          Length = 298

 Score =  208 bits (529), Expect = 2e-52,   Method: Compositional matrix adjust.
 Identities = 124/292 (42%), Positives = 162/292 (55%), Gaps = 3/292 (1%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           ++R+ +R S LAL QA  V  K+     GL   ++P+ T GD+I +  L  +GGKGLF+K
Sbjct: 2   IIRVGSRASRLALIQAQAVVQKI-NDLLGLNAIIIPIKTTGDLIQNKNLYDIGGKGLFLK 60

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           E+E ALL N  DIAVHS+KDVP   P GL L  + ER D  D  VS   + +  LP G+I
Sbjct: 61  EIEYALLNNTIDIAVHSLKDVPAYLPDGLQLAAVLERGDVGDMLVSKIANKITDLPLGAI 120

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE-SRI 183
           VGTSS+RR+ QL   RPDL I   RGNV TR +K+ N E DA +LA AGL+RL  + SR 
Sbjct: 121 VGTSSVRRRIQLLMLRPDLNIVLFRGNVDTRWNKIINNEVDATVLAAAGLQRLNYDTSRF 180

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              +P    LPA+GQGA+ IE R DD     L A +NH  T   +  ER     L   C 
Sbjct: 181 CNIIPQSEMLPAIGQGAIAIEARKDDKLIMPLCAKINHQLTWQLIQVERGYLKTLNADCN 240

Query: 244 VPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
           VPIG  A  I +     + ++G  +       E RG  Q    +G+  A+  
Sbjct: 241 VPIGGIASYIGNNSFEAKFMLGDYNMRYFFYSEVRGKLQHGYDIGVEAAKNF 292


>UniRef50_Q1EPC8 Porphobilinogen deaminase, chloroplast (Hydroxymethylbilane
           synthase) (Pre-uroporphyrinogen synthase), putative n=1
           Tax=Musa acuminata RepID=Q1EPC8_MUSAC
          Length = 328

 Score =  207 bits (526), Expect = 5e-52,   Method: Compositional matrix adjust.
 Identities = 129/291 (44%), Positives = 167/291 (57%), Gaps = 34/291 (11%)

Query: 11  RQSPLALWQAHYVKDKLMASHPGLV----VELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66
           R S LAL QA   +DKL A+H  L     VE++ + T GD+ILD PLA +GGKGLF KE+
Sbjct: 54  RDSDLALAQARETRDKLKAAHSELAEEGAVEIIIIKTTGDMILDKPLADIGGKGLFTKEI 113

Query: 67  EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126
           + ALL+ R DIAVHSMKDVP   P+G   +  C                   LPA     
Sbjct: 114 DDALLQGRIDIAVHSMKDVPTYLPEGT--ILPCN------------------LPA----- 148

Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAA 186
             SLRRQ Q+  R P L + +LRGNV TRL+KL NG+  A +LA+AGLKRL +   + + 
Sbjct: 149 --SLRRQSQILCRYPSLKVVNLRGNVQTRLTKLKNGDVHATLLALAGLKRLNMVENVTSI 206

Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246
           L  E  LPAV QGA+GI CR +D++  E L++LNH +T   V  ER   T L+G C+ PI
Sbjct: 207 LSMEEMLPAVAQGAIGIACRSNDNKMMEYLSSLNHEDTRSAVACEREFLTVLDGNCRTPI 266

Query: 247 GSYAEL-IDGEIWLRALVGAPDGSQIIRGERRG--APQDAEQMGISLAEEL 294
            +YA    DG    R L+ +PDGS++    R G  +  D  +MG     EL
Sbjct: 267 AAYAHRDKDGSCSFRGLLASPDGSKVYETTRIGPYSFDDMVEMGKDAGHEL 317


>UniRef50_C1CYD9 Porphobilinogen deaminase n=3 Tax=Deinococci RepID=HEM3_DEIDV
          Length = 311

 Score =  207 bits (526), Expect = 5e-52,   Method: Compositional matrix adjust.
 Identities = 126/304 (41%), Positives = 178/304 (58%), Gaps = 5/304 (1%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDT--PLAKVGGKGLF 62
            + + TR S LAL Q  +V  +L    P     +  + T+GD   ++   +A+ G KG +
Sbjct: 3   TVTVGTRGSTLALAQTRWVVARLKEEWPDTDFRIQTISTKGDRNRESLEAMAQKGDKGFW 62

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALPA 121
           VKE+E ALL+ R DIAVHS+KD+P E P+GL + +I +R D RD  +       L  LP 
Sbjct: 63  VKEIEDALLQKRIDIAVHSLKDLPTEQPEGLEVASIPKRVDARDVLIGKEGMKRLADLPQ 122

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ VGTSS+RR+  L   RPDL +  LRGN+ TRL+ L   EYDAIILA AGL R  +  
Sbjct: 123 GARVGTSSVRRKAFLRAYRPDLQVIDLRGNIDTRLAALAGDEYDAIILAAAGLIRTEMRH 182

Query: 182 RIRAALPPEISLPAVGQGAVGIECRL--DDSRTRELLAALNHHETALRVTAERAMNTRLE 239
           RI   + P+I LPA GQGA+ +E R   ++  T E+  A++ H T  R+TAER     L 
Sbjct: 183 RIDEFVEPDILLPAPGQGALALETRSGPENDLTIEVAYAIHDHGTDDRITAEREFLAGLG 242

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
            GC  P+G++A +  G + L   VGA DGS++IR    G P +   +G  LA ++L  GA
Sbjct: 243 AGCMAPVGAHASIKGGVLTLEGWVGALDGSKVIRATSIGDPAECADIGAELAGDMLGQGA 302

Query: 300 REIL 303
           + ++
Sbjct: 303 QALI 306


>UniRef50_B8GXG1 Porphobilinogen deaminase n=8 Tax=Caulobacteraceae RepID=HEM3_CAUCN
          Length = 322

 Score =  205 bits (522), Expect = 1e-51,   Method: Compositional matrix adjust.
 Identities = 132/285 (46%), Positives = 169/285 (59%), Gaps = 21/285 (7%)

Query: 6   LRIATRQSPLALWQ--------AHYV-------KDKLMASHPGLVVELVPMVTRGDVILD 50
           +RI  R S L+L Q        AH +       KD++ A+ P     L+P+VT GD I D
Sbjct: 7   IRIGARGSKLSLAQSGLMQARIAHALGVPAGASKDEIEAAAP-----LIPIVTSGDRIQD 61

Query: 51  TPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS 110
             L ++GGKGLF KE+E ALL+ R D AVHS+KD+P E P GL L    EREDPRDAF+S
Sbjct: 62  RRLMEIGGKGLFTKEIEEALLDGRIDCAVHSLKDMPAELPPGLVLAATPEREDPRDAFIS 121

Query: 111 NNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILA 170
           +  + L+ LP G+ +GT+SLRRQ Q    RPDL I  LRGNV TRL+KL+ GE DAI+LA
Sbjct: 122 HVCERLEDLPKGARLGTASLRRQAQALHVRPDLEIVMLRGNVDTRLAKLERGEADAILLA 181

Query: 171 VAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTA 230
            +GL RLGL    R+ L P+   PA GQGA+ IE R +D      L A+   +T + V A
Sbjct: 182 QSGLNRLGLGHLTRSWLDPDACPPAPGQGALVIETRAEDIGA-PWLEAVRCRQTTIAVAA 240

Query: 231 ERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE 275
           ER     LEG C+  IG+ A L    + +      PDG+Q  R E
Sbjct: 241 ERGALLALEGSCRTAIGARAILDGARLSMIVEALTPDGAQRFRRE 285


>UniRef50_Q8TXC8 Probable porphobilinogen deaminase n=1 Tax=Methanopyrus kandleri
           RepID=HEM3_METKA
          Length = 298

 Score =  205 bits (522), Expect = 1e-51,   Method: Compositional matrix adjust.
 Identities = 126/302 (41%), Positives = 181/302 (59%), Gaps = 9/302 (2%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLV-VELVPMVTRGDVILDTPLAKVGGKG 60
           +   +R+ATR S LA+ Q   V + L    P  V VE+V   +RGDV+ D PL K+G KG
Sbjct: 1   MSETIRVATRSSRLAIIQTREVIELLERESPRDVEVEIVKTKSRGDVVRDRPLHKLGEKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVP--VEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118
           +FVKE++  +LE +ADIAVHS KDVP  V++P  + +  +  R DPR+  VS  +  L  
Sbjct: 61  VFVKEVDRLVLEGKADIAVHSAKDVPSVVDYP--VDVAAVPPRRDPRECLVSR-HGGLKE 117

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178
           LP G+ VGTSS RR+ Q+   RPDL +  +RGNV TR+SK+   EYDA +LA  GL RLG
Sbjct: 118 LPRGATVGTSSPRRRAQILLERPDLKVEPMRGNVDTRVSKVRRREYDAAVLAKVGLDRLG 177

Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
           + S +     PE  +P  GQGA+ I CR DD R + LL  ++  ++ + V  E+A+   L
Sbjct: 178 MTSEVSEVYDPEEFVPPAGQGALMITCRKDDDRVKRLLEVVDDEKSRVEVETEKAVVREL 237

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVG--APDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
             GC  P+G +    DG+  +R ++G    DGS     + RG+P+D  +  +S A E+L+
Sbjct: 238 GVGCSEPVGVHVRARDGD-HVRLVLGLFEEDGSCGHVLKMRGSPEDVVREAVSQAREVLS 296

Query: 297 NG 298
           +G
Sbjct: 297 DG 298


>UniRef50_B2IAW6 Porphobilinogen deaminase n=4 Tax=Alphaproteobacteria
           RepID=B2IAW6_BEII9
          Length = 337

 Score =  205 bits (522), Expect = 1e-51,   Method: Compositional matrix adjust.
 Identities = 141/307 (45%), Positives = 180/307 (58%), Gaps = 7/307 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMV---TRGDVILDTPLAKVGGKGLF 62
           LR+ TR SPLAL QAH + D+L  +H G   E V +    T GD+I D PL+  GGKGLF
Sbjct: 19  LRLGTRGSPLALAQAHELADRLARAH-GFAKEAVAITIIRTSGDMIQDRPLSLAGGKGLF 77

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122
            KEL+ AL+E   D+AVHS KD+P   P+ L +     RED RD ++S        LP G
Sbjct: 78  TKELDQALIEGMVDLAVHSAKDLPTILPEDLIIAGYLPREDVRDVWISPKAGHPRDLPPG 137

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           S+VGT+SLRR   L   RPDL +R LRGNV TRL+KL  GE DA +LA+AGL+RLGL  +
Sbjct: 138 SVVGTASLRRGALLKRLRPDLEVRLLRGNVETRLAKLAAGEVDATLLALAGLRRLGLADK 197

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
               L  E  LPA GQGA+GI  R DD+ T  LLA +    T + + AER   T L+G C
Sbjct: 198 ATQVLAIEDFLPAAGQGAIGITTRRDDAATLALLAPILDPATHVALAAERGFLTVLDGSC 257

Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302
           + PIG++A +   ++ LR +V  PDGS+       G     E   +  A EL    AR I
Sbjct: 258 KTPIGAHATVEHDQVTLRGIVLRPDGSEWFEACESGP---LESGSLEAARELGETAARAI 314

Query: 303 LAEVYNG 309
           LA +  G
Sbjct: 315 LARLPEG 321


>UniRef50_Q11XT5 Porphobilinogen deaminase n=8 Tax=Bacteria RepID=HEM3_CYTH3
          Length = 312

 Score =  204 bits (520), Expect = 3e-51,   Method: Compositional matrix adjust.
 Identities = 129/311 (41%), Positives = 177/311 (56%), Gaps = 6/311 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           ++  +RI TR S LALWQA +V   L     GL  ++V + T GD ILD  L+K+G KGL
Sbjct: 1   MNKTVRIGTRGSKLALWQAEHVAACLQT--KGLEPQIVIIDTTGDKILDQSLSKIGSKGL 58

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALP 120
           F +ELE  L     DIAVHS KD+      G+ ++ I ERE   D  VS+   D+L   P
Sbjct: 59  FTEELEEQLHAGTIDIAVHSAKDLQTHLKGGMYILAITERELVNDVLVSHKPIDTLKNNP 118

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
              I+GTSS RR+  L +  P   +  +RGN+ TR+ K++ G  DA++LA AG+ R+G +
Sbjct: 119 -DLIIGTSSTRRRALLRKFYPQAKMVDMRGNLQTRIRKMEEGACDAMLLAYAGMHRMGYD 177

Query: 181 SRIRAALPPEISLPAVGQGAVGIEC--RLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
           S I+  L  E  +PA GQG + IE    LD  +   + A LN   T   V+AERA    L
Sbjct: 178 SLIKEKLSLEEFIPAAGQGTLAIEAASTLDKEKAAVIRAVLNDAATETAVSAERAFLRTL 237

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
           EGGC +P+ + A   D +  L   + + DG++ +R E R    DAEQ G+ LA  LL +G
Sbjct: 238 EGGCSIPVFALAVERDTDYLLTGGIVSLDGTKYLRKEIRFTAADAEQRGVELATVLLKDG 297

Query: 299 AREILAEVYNG 309
           A EILAE+  G
Sbjct: 298 ADEILAEIKKG 308


>UniRef50_A2BL26 Probable porphobilinogen deaminase n=2 Tax=Thermoprotei
           RepID=HEM3_HYPBU
          Length = 303

 Score =  204 bits (518), Expect = 4e-51,   Method: Compositional matrix adjust.
 Identities = 127/298 (42%), Positives = 168/298 (56%), Gaps = 3/298 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LR+ATR S L++ Q     + +    P L  ELV + TRGD+  D P   +GGKGLF KE
Sbjct: 3   LRVATRGSKLSIAQTMIALEAIKRVEPSLEYELVIVKTRGDIHQDKPFTAIGGKGLFEKE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV--SNNYDSLDALPAGS 123
           + +A+LE RADIAVHS+KDVP     GL L     R+ P D  V       ++  LP+G+
Sbjct: 63  VNLAVLEGRADIAVHSLKDVPSAISPGLVLAMTPPRDPPYDVLVVRGGKEKTIWDLPSGA 122

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           IVGTSS RR   L   R DL+ + LRGNV TRL KL+ G+YDAI+LA AGLKRLG++   
Sbjct: 123 IVGTSSARRVAMLKHVRRDLVFKVLRGNVDTRLRKLEQGQYDAIVLAEAGLKRLGVDIEY 182

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              +PP+I  PA GQG +G+      S    +L   +  +      AERA      GGC 
Sbjct: 183 -WRIPPDILPPAPGQGIIGVYTLSSRSDILPILEKASDQKAMAEARAERAFLAYAGGGCH 241

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
            P+G+YAEL    ++  A + +PDGS+ +     G P    Q+G+  A EL    ARE
Sbjct: 242 TPLGAYAELRGNTLYFHAALASPDGSRRVEVRVEGDPDKPTQVGLEAAFELRRLAARE 299


>UniRef50_B3T8H9 Putative Porphobilinogen deaminase, dipyromethane cofactor binding
           domain protein n=1 Tax=uncultured marine microorganism
           HF4000_APKG5H11 RepID=B3T8H9_9ZZZZ
          Length = 322

 Score =  204 bits (518), Expect = 4e-51,   Method: Compositional matrix adjust.
 Identities = 121/299 (40%), Positives = 170/299 (56%), Gaps = 1/299 (0%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +++ +R S LAL Q H V ++L A+ P L  E+  + TRGDV   + LA +G  G+FVKE
Sbjct: 18  IKVGSRGSTLALIQDHVVINRLKANSPALEFEVDTVRTRGDVDQTSRLAGMG-LGIFVKE 76

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           LE  LL+ + DIAVHS+KD+P +   GL L  +  REDPRD  V+     LD LP G+ +
Sbjct: 77  LEQELLDGKLDIAVHSLKDMPTQLADGLVLGAVLSREDPRDVLVNRYGCPLDGLPKGAKI 136

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS RR  QL +  P + + S+RGNV TRL K    E D  ILA AG+ RLGL+ +I  
Sbjct: 137 GTSSPRRAAQLKQYAPQVEVVSIRGNVETRLRKAQGEEADGAILAAAGMIRLGLQDQIAE 196

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L     +P  GQG + +E R DD R  ELL+A++  +T    TAER    RL GGC +P
Sbjct: 197 YLSATQFVPPPGQGILAVEARADDFRMLELLSAIDDADTRYEATAERGFLARLGGGCSIP 256

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304
           +G+YA      I +   +   DG +    + +G  +D  Q+       L+  G  +++A
Sbjct: 257 VGAYARCNGDNIVMTIYMSTADGEKKFSAKIQGLKRDPLQLANDAYLALVERGGADLVA 315


>UniRef50_B0K2L4 Porphobilinogen deaminase n=7 Tax=Bacteria RepID=B0K2L4_THEPX
          Length = 299

 Score =  204 bits (518), Expect = 4e-51,   Method: Compositional matrix adjust.
 Identities = 110/296 (37%), Positives = 172/296 (58%), Gaps = 3/296 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +  V+++ TR S LAL Q   V +++         E+V + T+GD ++D P++++GGKG+
Sbjct: 1   MKKVIKVGTRSSELALKQTAMVINEIKKFRQDFEFEIVKITTQGDALIDKPVSEIGGKGV 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FVKE+E ALL+   D+AVHSMKD+P E P+GL L+ + +REDP+D FVS +      L  
Sbjct: 61  FVKEIESALLKGEIDMAVHSMKDMPYEIPKGLKLMAVLKREDPKDVFVSGDGTQFMDLKE 120

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ +GTSSLRRQ QL   +PD+ I  +RGNV TRL K++    D I+L+ AGL RLGLE+
Sbjct: 121 GAKIGTSSLRRQVQLKALKPDIQIVPIRGNVRTRLKKMEELNLDGIVLSAAGLHRLGLEN 180

Query: 182 RIRAALPPEISLPAVGQGAVGIE-CRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            I    PP++ +PA  QG + +E     D+  +E    +   +T    + ER +      
Sbjct: 181 IITEYFPPDVVVPAPCQGILAVEIAESFDNIFQEFYPYIVDRKTFFEASVERELLKAFGV 240

Query: 241 GCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
            C+ P G+YA+    + E  +   V     +++++ E  G  ++ ++M   L EE 
Sbjct: 241 NCRQPFGAYAQYRKEEDEEKINIKVAYQKENKLLKSEVTGLIEETDKMIEKLIEEF 296


>UniRef50_A0QLI0 Porphobilinogen deaminase n=69 Tax=Actinomycetales RepID=HEM3_MYCA1
          Length = 315

 Score =  204 bits (518), Expect = 4e-51,   Method: Compositional matrix adjust.
 Identities = 136/310 (43%), Positives = 178/310 (57%), Gaps = 15/310 (4%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMA-SHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           ++RI TR S LA  QA  V+D L+A  HP    ELV + T GD     P+  +G  G+F 
Sbjct: 1   MIRIGTRGSLLATTQAGGVRDALIARGHP---AELVTITTAGDRS-SGPIESLG-VGVFT 55

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
             L  A+ E R D AVHS KD+P        +  I  R DPRDA V+ +   L  LP GS
Sbjct: 56  TALREAIEEGRVDAAVHSHKDLPTADDPRFAVAAIPARNDPRDAVVARDGLVLGELPPGS 115

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           +VGTSS RR  QL      L IR LRGN+ TRL+++ +G+ DAI++A AGL RLG    +
Sbjct: 116 LVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLGDV 175

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              L P   LPA  QGA+ +ECR  DSR   +LA L+  +T   VTAERA+   LE GC 
Sbjct: 176 TETLEPVQMLPAPAQGALAVECRAGDSRLAAVLAELDDADTRASVTAERALLAELEAGCS 235

Query: 244 VPIGSYAELI-----DGEIW----LRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
            P+G+ AE++     DG I+    LR  V A DGS +IR    G P  A ++G+S+A EL
Sbjct: 236 APVGAIAEVVESIDEDGRIFEELSLRGCVAALDGSDVIRASGIGTPGRARELGLSVAAEL 295

Query: 295 LNNGAREILA 304
              GARE+++
Sbjct: 296 FELGARELMS 305


>UniRef50_D1CBT4 Porphobilinogen deaminase n=1 Tax=Thermobaculum terrenum ATCC
           BAA-798 RepID=D1CBT4_THET1
          Length = 300

 Score =  202 bits (515), Expect = 1e-50,   Method: Compositional matrix adjust.
 Identities = 112/297 (37%), Positives = 171/297 (57%), Gaps = 2/297 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
            V+++ TR S LALWQ  +V ++L + +PG   E V +    D   D P++ +G  G+F 
Sbjct: 2   KVIKVGTRGSKLALWQTQWVINRLRSLYPGFQFEPVVIKVTSDRSPDAPISAIGQVGVFT 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           K++E ALL     +AVHS+KD+P     G  +    EREDPRD  +      +  L   S
Sbjct: 62  KDIEQALLAGDIHLAVHSLKDLPTLSTPGTVIAAFTEREDPRDCILWPKGQPMPDL-NNS 120

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            VGTSS+RR   +    P+  + +LRGNV TR+ K+  G YD +++A A +KR+ L    
Sbjct: 121 RVGTSSVRRSALVRSYWPNANVVNLRGNVDTRVRKMLEGNYDVVLMAYAAVKRMDLPVEF 180

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
           +  LP +  +P+ GQG + ++ R DD +   +L A+N   + +   AER++   L GGC 
Sbjct: 181 KP-LPLDSWVPSAGQGIIAVQAREDDQQIIGMLNAINFFPSKVAYLAERSLMRALGGGCS 239

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           +P+G+YAEL DGE+ L  +V APDGSQ++   R   P  A+ +G  +A E+L+ G R
Sbjct: 240 MPVGAYAELHDGELSLIGMVAAPDGSQVVITRRVDTPDQADHLGERVAREMLDLGIR 296


>UniRef50_A6GVP0 Hydroxymethylbilane synthase n=18 Tax=Bacteroidetes
           RepID=A6GVP0_FLAPJ
          Length = 308

 Score =  202 bits (515), Expect = 1e-50,   Method: Compositional matrix adjust.
 Identities = 112/308 (36%), Positives = 174/308 (56%), Gaps = 8/308 (2%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M    ++I TR S LALWQAH+V+   M +  G   +++ + ++GD+ILD PL ++G  G
Sbjct: 1   MAKKTIKIGTRDSELALWQAHHVEK--MLNDLGHKTKIIAVKSQGDIILDKPLYELGITG 58

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           +F K L++A++    DIAVHSMKDVP   PQG+    + ER + +D  V NN  +LD L 
Sbjct: 59  IFTKTLDIAMVNGDIDIAVHSMKDVPTALPQGIVQAAVLERANEKDILVYNN--NLDFLN 116

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
             + + T SLRRQ Q   + P+  +  LRGNV TR+ KL +  ++  + A AGL+R+ ++
Sbjct: 117 TQATIATGSLRRQAQWLHKYPNHKVVDLRGNVNTRMQKLQDNNWNGAVFAAAGLERINIK 176

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
                 L  +  +PA  QGA+ +    +D+   + LA LNH ET +    ER     LEG
Sbjct: 177 PENYINL--DWMIPAPAQGAMMVVAMGNDTYCLDALAELNHIETEITTYIERQFLRTLEG 234

Query: 241 GCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
           GC  PIG+YA     D  I  + ++ + DGSQ I  ++    Q+ +Q+G    +E+  NG
Sbjct: 235 GCTAPIGAYARFNEKDETIHFQGVLFSLDGSQKIEIKKIVEIQEWKQLGYHAGQEIFENG 294

Query: 299 AREILAEV 306
             +++  +
Sbjct: 295 GVQLMKTI 302


>UniRef50_A0LRF1 Porphobilinogen deaminase n=1 Tax=Acidothermus cellulolyticus 11B
           RepID=HEM3_ACIC1
          Length = 331

 Score =  201 bits (512), Expect = 2e-50,   Method: Compositional matrix adjust.
 Identities = 129/305 (42%), Positives = 167/305 (54%), Gaps = 8/305 (2%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           +VLR+ TR+S LA  Q   +   L A+  G  VE+V + + GD   D PL +  G G+FV
Sbjct: 8   SVLRLGTRRSTLARAQTEEIAGALRAA--GCRVEIVGIQSTGDRHADVPLHEFAGSGVFV 65

Query: 64  KELEVALLENRADIAVHSMKDVPV-EFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122
            EL  ALL    D+ VHSMKD+P  E P+ L +  I  R DPRDA V+     L  LP G
Sbjct: 66  AELRAALLRGEVDVVVHSMKDLPTAEIPE-LAIAAIPRRADPRDALVTGAGCRLAELPTG 124

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           +IVGT S RR  QL   RPDL IR +RGN+ TRL KL  G Y A+I+A AGL RL     
Sbjct: 125 AIVGTGSPRRAAQLRLLRPDLEIRPIRGNLDTRLGKLHAGGYAALIVAAAGLARLHRSEE 184

Query: 183 IRAALPPEISLPAVGQGAVGIECR----LDDSRTRELLAALNHHETALRVTAERAMNTRL 238
                 P + LPA GQGA+ +ECR     D  R   +LA L+   T   VTAERA+   +
Sbjct: 185 AAEFFDPTVMLPAPGQGALAVECRRADIADGGRLAGILAGLDDPATRAAVTAERALLAAV 244

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
             GC  P+G+   +    + L A+V  P G+   R    G P DA  +G  LA +L+  G
Sbjct: 245 GAGCSAPVGALGVVTADTLQLDAVVVDPSGTTAFRRSLTGTPDDASDLGRRLAADLIRAG 304

Query: 299 AREIL 303
           A ++L
Sbjct: 305 ADQLL 309


>UniRef50_A9A1A1 Probable porphobilinogen deaminase n=3 Tax=Thaumarchaeota
           RepID=HEM3_NITMS
          Length = 311

 Score =  201 bits (512), Expect = 2e-50,   Method: Compositional matrix adjust.
 Identities = 107/295 (36%), Positives = 171/295 (57%), Gaps = 2/295 (0%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67
           +  R S L++ Q + V  +L  +HP    E+  + T+GD     PL  +  KG+F KE++
Sbjct: 5   VGARGSQLSVAQTNLVIAELKKAHPDTEYEIKTITTKGDTD-SRPLFTIDQKGIFEKEID 63

Query: 68  VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127
            A+ +   D AVHS+KDVP E    L L  I +RE   D F+S +  +LD++  GS++GT
Sbjct: 64  RAVAQKEVDFAVHSLKDVPSELDDNLVLACIPKRETVNDVFISPDGSTLDSIKPGSVIGT 123

Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAAL 187
           SSLRR  Q++ +RPD+ ++ +RGN+ TR+ K     YDAI+LA AG+ RLG++ +     
Sbjct: 124 SSLRRAVQVSRKRPDVTVKPIRGNIETRIKKASGENYDAIVLAKAGISRLGVDVKYTELS 183

Query: 188 PPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIG 247
             + S P+ GQGA+ I  R DDS+T E+L  +   ++ L + AERA++  ++ GC+ P+G
Sbjct: 184 TDDFS-PSPGQGAIAIVARADDSKTIEMLKKIEDPDSRLEIEAERALSDFVDSGCRFPVG 242

Query: 248 SYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302
           +YA+    E+ L     + DG Q +   + G   + + +G S  EEL   G  ++
Sbjct: 243 AYAKSNGSEMTLTVTAFSVDGKQFLHVSKTGDKNNPKSLGQSAGEELREKGVNDL 297


>UniRef50_C6WZF5 Porphobilinogen deaminase n=1 Tax=Flavobacteriaceae bacterium
           3519-10 RepID=C6WZF5_FLAB3
          Length = 311

 Score =  201 bits (511), Expect = 3e-50,   Method: Compositional matrix adjust.
 Identities = 111/302 (36%), Positives = 175/302 (57%), Gaps = 7/302 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           ++I TR SPLALWQA  V   L  ++     ++ P++++GD  L  PL  +G  G+F K+
Sbjct: 12  IKIGTRNSPLALWQAREVARHLQNNNH--TTDITPIISKGDKNLSQPLYTLGITGIFTKD 69

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L++ALL N  DIAVHS+KD+P + P+ + ++ + +R+ P+D  V     +   L    I 
Sbjct: 70  LDIALLNNEVDIAVHSLKDIPTQLPENVEIIAVLQRDYPQDVLVRKKDAATLELHQLKI- 128

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
            TSSLRR+    +  P      +RGNV TRL+KL+  ++DA + ++A ++R+GL S    
Sbjct: 129 ATSSLRRRAFWLKEFPGTEFSDIRGNVQTRLTKLEENDFDATMFSLAAIERMGL-SVDYE 187

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            LP  + +PA  QG V +  R +D   +EL   +NH ET + +  ER+  + LEGGC  P
Sbjct: 188 HLP--LMIPAPAQGVVAVCARSNDPEIKELFKEINHRETRICIDIERSFLSTLEGGCTAP 245

Query: 246 IGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304
           IG++AE+ D GE+     + + DG   I  +   A  + +  G  LAE++L NG RE++ 
Sbjct: 246 IGAFAEINDLGEVRFTGRICSLDGQNCIETDEIFAWNEHDDFGKILAEKILQNGGRELMQ 305

Query: 305 EV 306
           E+
Sbjct: 306 EI 307


>UniRef50_Q1V167 Hydroxymethylbilane synthase n=3 Tax=Candidatus Pelagibacter
           RepID=Q1V167_PELUB
          Length = 307

 Score =  201 bits (510), Expect = 3e-50,   Method: Compositional matrix adjust.
 Identities = 111/290 (38%), Positives = 165/290 (56%), Gaps = 3/290 (1%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELV---PMVTRGDVILDTPLAKVGGKGLFVK 64
           I +R S LAL  A   ++K++       +E V    +VT+GD + D  L++VGGKGLF K
Sbjct: 8   IGSRGSKLALIYAEKAREKILKHSKDFGIEEVIIKEIVTKGDQVQDKRLSEVGGKGLFSK 67

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
            +EV LLE + DIAVH++KD+P E  +GL      ER DPR+  +S +   L  L + SI
Sbjct: 68  TIEVELLEKKIDIAVHALKDMPSEETRGLLTDCFLERNDPREILISKDNKHLKDLASNSI 127

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GTSS RR+ Q+ + R DL  + +RGNV TR+ KL    YDAIIL+ AG+  LGL   I 
Sbjct: 128 IGTSSYRREFQIKKIRDDLNCKLIRGNVDTRIRKLKENLYDAIILSYAGIDSLGLNQNIS 187

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
                   +P  GQG + ++CR +D    ELL  ++H  T   + AER +   LEG C+ 
Sbjct: 188 QTFSTSEIIPCAGQGVIALQCRDNDESLIELLKQVDHQSTHSSIKAERNVLKVLEGDCET 247

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
            +G++A +   +I L   + + DGS+    +   +   AE++GI + + L
Sbjct: 248 AVGAFANIEGNKINLEVELFSLDGSKRFYLKSSESVDKAEELGIEMGKTL 297


>UniRef50_A2Q9P7 Catalytic activity: 4 porphobilinogen+H(2)O<=>hydroxymethylbilane+4
           NH(3) n=1 Tax=Aspergillus niger CBS 513.88
           RepID=A2Q9P7_ASPNC
          Length = 346

 Score =  201 bits (510), Expect = 4e-50,   Method: Compositional matrix adjust.
 Identities = 123/324 (37%), Positives = 177/324 (54%), Gaps = 24/324 (7%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG-----KG 60
           LR+ TR S LAL QA +V  +L ++HPG+      +V RGD    +P  K  G     K 
Sbjct: 12  LRLGTRNSKLALVQAEHVSKELTSAHPGVQFPWQTVVVRGDADKSSPFLKFAGPSDAAKN 71

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV-----SNNYDS 115
           ++ +E+E  L     D+ VH +KD+P   P+   L  I  REDP DA V      + Y  
Sbjct: 72  IWTEEMETKLCAGELDLLVHCLKDMPTRLPETCTLGAIVYREDPTDALVIKEGLRSQYTD 131

Query: 116 LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN--GEYDAIILAVAG 173
           L  LP GS+VGTSS RR+  L  R P L +   RGN+GTRL KLD+  G + AIILA AG
Sbjct: 132 LSQLPPGSVVGTSSTRRKALLRYRYPHLKVEECRGNLGTRLKKLDDPEGPFSAIILATAG 191

Query: 174 LKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERA 233
           + R+ LE RI   LPP     AVGQGA+GIE R +D++T+ ++  +    T     AER+
Sbjct: 192 MVRINLEDRITKRLPPSEFPYAVGQGALGIEIRKEDAQTKTMVRKIEDLVTRRICLAERS 251

Query: 234 MNTRLEGGCQVPIGSYAELID-------GEIWLRALVGAPDGSQIIRGERR----GAPQD 282
           +   L+GGC  P+  +  +          ++ L   +  P G+ ++  ER     G  +D
Sbjct: 252 LLRTLQGGCSSPVAVHCTVEQAPTASSPAQLRLDGTIIHPHGTTLL-SERTTAEVGTDED 310

Query: 283 AEQMGISLAEELLNNGAREILAEV 306
           AE +G ++A++LL NG + +L E+
Sbjct: 311 AEALGATVAQQLLKNGGQALLEEI 334


>UniRef50_Q9F7M2 Predicted porphobilinogen deaminase n=2 Tax=Bacteria
           RepID=Q9F7M2_PRB01
          Length = 303

 Score =  200 bits (509), Expect = 4e-50,   Method: Compositional matrix adjust.
 Identities = 110/298 (36%), Positives = 170/298 (57%), Gaps = 2/298 (0%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RIATRQS LA++QA +V D+L+A    + VELVPM + GD   D PL ++GGKGLF+  
Sbjct: 3   IRIATRQSELAMYQAKFVADELLAKINNIKVELVPMTSEGDQT-DKPLHEIGGKGLFIST 61

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           LE +L  + ADIAVHS+KDVP +      ++++  RE P D  +S +  S       S +
Sbjct: 62  LESSLEADEADIAVHSLKDVPAKLDPKFKIISVFSRESPEDLLLSKDGKSFSEFARNSTI 121

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTS  RR+ Q+   RPD+    +RGN+ TR+ KL++G +D +++A A +KRLGL+     
Sbjct: 122 GTSGPRRKAQINNLRPDIKTIPVRGNIATRIKKLNDGLFDGLVVAKAAIKRLGLKQN-SY 180

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
               E  LP+  QG + IEC  D     ELL  +   +  +  +AER+    +EG C  P
Sbjct: 181 EFSIEEMLPSASQGYIAIECLSDKKDIIELLENIGDPKELILASAERSFVAAMEGTCLSP 240

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           I    E  +G+I +   + + +G++ I  E+  + QD     +  A+E +  GA+ ++
Sbjct: 241 IAILCEDKNGQIKISGKILSYEGNEKIYKEKISSFQDIAIDIMLFADEFILEGAKSLI 298


>UniRef50_C7N5L0 Porphobilinogen deaminase n=2 Tax=Slackia RepID=C7N5L0_SLAHD
          Length = 318

 Score =  200 bits (508), Expect = 5e-50,   Method: Compositional matrix adjust.
 Identities = 121/307 (39%), Positives = 169/307 (55%), Gaps = 5/307 (1%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67
           I TR S LALWQ   V   +M + P + VE+    T GD+ L +PLA++G KGLF +ELE
Sbjct: 7   IGTRGSKLALWQTETVGRAIMRAFPEIEVEIRVRNTTGDINLASPLAEIGDKGLFTRELE 66

Query: 68  VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALPAGSI 124
             LL    D+ VHS+KD+  E P+G  +  +  R D RD  V        SL  +P GS 
Sbjct: 67  TDLLLGEVDMCVHSLKDLETEQPEGCVVAGVLPRADARDVLVCGPRIQAASLAEVPEGSR 126

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GT S RR  QL    P+++   +RGNV TR++K +  +Y+  ILA AG+KR+G E  I 
Sbjct: 127 IGTGSRRRVAQLKANFPNMVPEGIRGNVDTRVAKAEGDDYEGAILAAAGMKRMGYEDHIA 186

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
           A LP E  +PA GQGA+ +E    + R  ++  ALN   T     AER +   LEGGC  
Sbjct: 187 AYLPIEDMIPAPGQGAIAMEVLKKNERAYQIARALNDPVTKACTDAERFVLFSLEGGCSA 246

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGIS--LAEELLNNGAREI 302
           PIG++  L DG+    A V +  G++  R         A+ M ++  +  EL+  GAR I
Sbjct: 247 PIGAHCRLEDGKYIFDACVLSLGGTKAARCHLEADADSADPMDMAWEVVSELIGEGARAI 306

Query: 303 LAEVYNG 309
           L ++ NG
Sbjct: 307 LRDIKNG 313


>UniRef50_Q0BX92 Porphobilinogen deaminase n=1 Tax=Hyphomonas neptunium ATCC 15444
           RepID=HEM3_HYPNA
          Length = 321

 Score =  199 bits (507), Expect = 8e-50,   Method: Compositional matrix adjust.
 Identities = 121/274 (44%), Positives = 162/274 (59%), Gaps = 7/274 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLV-VELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           LR+ TR SPLAL QAH + D + A+  G    E+V   T GD +    L   GGKGLF +
Sbjct: 13  LRLGTRGSPLALAQAHQIADGIRAASAGAYDCEIVAFTTTGDKLTTERLINSGGKGLFTR 72

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           EL+ AL     D+AVHS+KDVP   P G       +REDPRD F+S+   S+  LP G+ 
Sbjct: 73  ELDDALSRGELDLAVHSLKDVPSVLPPGQIFAAFPKREDPRDGFLSHGAKSIQDLPEGAT 132

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GT+SLRR+ Q    RPDL + + RGNV TR+ KL+ G  DA  LA+AGL RLGL S + 
Sbjct: 133 LGTASLRREAQALALRPDLKVVTFRGNVATRMRKLEEGLADATFLAMAGLTRLGL-SEVA 191

Query: 185 AALPPEISLPAVGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
             +P E  LPA GQG +G+  R D D+   E+L  L+H  + +   AERA   +L+G C+
Sbjct: 192 TPIPLEDMLPAAGQGIIGVVTRDDVDTELLEILGQLSHEPSRVAAIAERAFLEKLDGSCR 251

Query: 244 VPIGSYAELID-GEIW-LRALVGAPDGSQIIRGE 275
            PI ++  L D G+ W L   V +P G+   RG+
Sbjct: 252 TPIAAH--LFDRGDEWQLIGEVLSPGGTTRWRGD 283


>UniRef50_A5VM67 Porphobilinogen deaminase n=9 Tax=Lactobacillus RepID=HEM3_LACRD
          Length = 305

 Score =  199 bits (507), Expect = 8e-50,   Method: Compositional matrix adjust.
 Identities = 119/296 (40%), Positives = 168/296 (56%), Gaps = 4/296 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           + N + + +R+S LA+ Q   V   L    P +  E+  ++T GD      LAK+GGKG+
Sbjct: 1   MTNKVIVGSRKSKLAMAQTELVIASLEKIFPDIKFEIKNVITEGDRNRHVSLAKIGGKGV 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS-NNYDSLDALP 120
           FVKE+E  L +   D AVHS+KDV    P+ L L    +R  P D  VS  N  SL+ LP
Sbjct: 61  FVKEIEDELKDGTIDFAVHSLKDVMPILPEELVLGAFPKRVSPYDCLVSRKNLSSLNDLP 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ +GT+SLRRQ QL   RPDL I  +RGN+ TRL K+D    D IILA AGL RL ++
Sbjct: 121 KGARIGTNSLRRQGQLLSIRPDLKIIPIRGNIDTRLRKIDTEALDGIILAEAGLTRLNID 180

Query: 181 SRIRAALPPE-ISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
                 L  +   +PAVGQG + IECR +D+R R++L  +N  E+A  V  ER     L 
Sbjct: 181 LSSYHVLDLQNYIMPAVGQGCLAIECRKNDTRIRKMLDQINDEESAYCVQVEREFMRELG 240

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295
           G C  PIG +A   +G+I    L+ +P+G  +I+  +   P +   +G  +A++LL
Sbjct: 241 GSCNFPIGGHAYAKNGQILFDGLIASPNGEHVIKETK--IPANNSGVGKKVADQLL 294


>UniRef50_Q47LA7 Porphobilinogen deaminase n=3 Tax=Actinomycetales RepID=HEM3_THEFY
          Length = 320

 Score =  199 bits (507), Expect = 9e-50,   Method: Compositional matrix adjust.
 Identities = 128/312 (41%), Positives = 177/312 (56%), Gaps = 11/312 (3%)

Query: 7   RIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66
           R+ TR+S +A  Q+  V + L A   G+ VELV + + GD I    L ++GG G+FV  L
Sbjct: 7   RLGTRRSTMATNQSRRVAEILTA-RTGVPVELVLITSFGD-ITRAHLTQLGGTGVFVSAL 64

Query: 67  EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126
             ALL    + AVHS+KD+P    +G+ L  + ER+DPRDA  + +      LP G+ VG
Sbjct: 65  RDALLAGEVEFAVHSLKDLPTAPTEGIVLAAVTERDDPRDALCARDGLKFADLPPGATVG 124

Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAA 186
           T S RR  QLA  RPDL    +RGN  TRL K+ +GE DA++LA AGL R+G    +   
Sbjct: 125 TGSPRRVAQLAALRPDLRYVPIRGNAETRLGKVASGELDAVVLAYAGLHRVGRLDDVTDV 184

Query: 187 LPPEISLPAVGQGAVGIECRLDD-SRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
              +  LPA GQGA+ +ECR  D +     L A++H  T   VTAER +   LE GC  P
Sbjct: 185 FDVDQVLPAPGQGALAVECRTADFTGPLRYLTAVDHLPTRAAVTAERVILAELEAGCAAP 244

Query: 246 IGSYAELI-DGEIWLRALVGAPDGSQIIRGERR-------GAPQDAEQMGISLAEELLNN 297
           +G+YAE + +  + LRA V A DGSQ +R E+         A Q A  +G  LA +++  
Sbjct: 245 VGAYAEFVAEDRLRLRAAVVATDGSQAVRAEQTVTVTEFPDAVQAATALGRQLAHDMIEQ 304

Query: 298 GAREILAEVYNG 309
           GA +I+A+   G
Sbjct: 305 GADQIVADAAAG 316


>UniRef50_C0YV01 Hydroxymethylbilane synthase n=1 Tax=Chryseobacterium gleum ATCC
           35910 RepID=C0YV01_9FLAO
          Length = 302

 Score =  199 bits (506), Expect = 1e-49,   Method: Compositional matrix adjust.
 Identities = 114/304 (37%), Positives = 172/304 (56%), Gaps = 12/304 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR S LALWQA  V   L  ++   + E+VP+V+ GD  L+ PL  +G  G+F ++
Sbjct: 4   IRIGTRNSALALWQAREVARHLQNNN--YLTEIVPIVSSGDKNLNQPLYSLGITGVFTRD 61

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDSLDALPAG 122
           L++ALL +  DIAVHS+KDVP + PQ + ++   ER+ P+D  +   S+       L   
Sbjct: 62  LDIALLNDEIDIAVHSLKDVPTQLPQNIEMIAYLERDYPQDILIRKESSRNKEFHELK-- 119

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
             + TSSLRR+       P      +RGN+ TRL KL+ G++DA IL++AG+KR+ +E  
Sbjct: 120 --LATSSLRRRAFWLRNYPTAEFSDIRGNIQTRLQKLEEGDFDATILSLAGIKRMKMEID 177

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
               LP  IS P+  QG + +    D     E++  +NH ET + V  ER   + LEGGC
Sbjct: 178 YEM-LPLMISAPS--QGVISVAGHTDKPEINEIVRQINHQETQICVEIERNFLSTLEGGC 234

Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302
             PIG++AE+I  +I  +A + + DG   I  +       AE  G   A+ +L NG +E+
Sbjct: 235 TAPIGAFAEIIGDQIRFKAALCSLDGKNCIAVDENFVYTPAENFGEKYAKVVLENGGKEL 294

Query: 303 LAEV 306
           +AE+
Sbjct: 295 MAEI 298


>UniRef50_D0NJW2 Porphobilinogen deaminase n=2 Tax=Phytophthora infestans T30-4
           RepID=D0NJW2_PHYIN
          Length = 361

 Score =  199 bits (506), Expect = 1e-49,   Method: Compositional matrix adjust.
 Identities = 123/310 (39%), Positives = 172/310 (55%), Gaps = 11/310 (3%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG---GKGLFVK 64
           +++R+S LA+ Q + V   L    P L   +    T GD +LD  L+ +G     GLF K
Sbjct: 18  VSSRKSQLAMAQTNTVIAMLEERFPDLQFVVGQEDTVGDQVLDRHLSDLGTTTASGLFTK 77

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV------SNNYDSLDA 118
            LE ALL   A  AVHS+KD+P   P GL L  I +RE P DA V           +L  
Sbjct: 78  SLEEALLAKAASFAVHSLKDMPTTLPDGLVLAAITKRESPEDAAVIHPKHKEKGIKTLQE 137

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD-NGEYDAIILAVAGLKRL 177
           LP GS++GTSSLRR+  L  + P   I+++RGN+ TRL+KLD + +YDAII+A  G +R 
Sbjct: 138 LPEGSVIGTSSLRREALLRSQFPTFEIKTVRGNIQTRLAKLDEHDDYDAIIVAACGFRRG 197

Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237
            L  RI   LP +     VGQG++G+ECR DD  T E+L  +   ++A    AER++   
Sbjct: 198 ELGDRIDEILPMDTFGYGVGQGSIGVECRADDEETIEMLKTITDEKSAQLCKAERSLLYH 257

Query: 238 LEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           LEGGCQ+ +G  A L +  + L A V + DG + +     G     E++G  LAE   NN
Sbjct: 258 LEGGCQIAMGVSATLDEDTLTLNATVLSRDGKESVHETISGPRTQCEELGKQLAERFWNN 317

Query: 298 G-AREILAEV 306
             AR++L + 
Sbjct: 318 ELARKVLGKT 327


>UniRef50_Q82P95 Porphobilinogen deaminase 2 n=14 Tax=Actinomycetales
           RepID=HEM32_STRAW
          Length = 314

 Score =  199 bits (505), Expect = 1e-49,   Method: Compositional matrix adjust.
 Identities = 124/306 (40%), Positives = 169/306 (55%), Gaps = 4/306 (1%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
            ++RI +R SP+AL Q   V+ +L A HP    E+V + T GD  +   L+KV GKG F 
Sbjct: 8   ELIRIVSRDSPMALAQVARVRAELAALHPRTRTEVVAVKTTGDKWMGD-LSKVDGKGAFT 66

Query: 64  KELEVALLENRADIAVHSMKDVPVE--FPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           KE++ ALL   AD+AVH +KDVP +   P G       +R+D RDA V     +LD LP 
Sbjct: 67  KEVDAALLAGEADLAVHCVKDVPADRPLPAGTMFAAFLKRDDIRDALVHPGGLTLDELPP 126

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ +GTSS+RR  QLA   P L     RGN   RL KL  GE DA++LAV+GL+R+G E 
Sbjct: 127 GTRIGTSSVRRVAQLAAAYPHLECVPFRGNANRRLEKLAAGEADALLLAVSGLERIGRED 186

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
            I   L PE  +P +G G + ++CR  D+   E ++ L    T    TAER     L+G 
Sbjct: 187 VITEVLEPETMMPPIGAGILALQCREGDTGLIETISELGDPGTHREATAERMFLHVLQGH 246

Query: 242 CQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           C  PI  YA    +GE+ LRA V   DG  ++         D   +G S+A  LL  GAR
Sbjct: 247 CNSPIAGYARTERNGELSLRASVFTLDGKTVLNAHEWAGRLDPATLGTSVAVALLRQGAR 306

Query: 301 EILAEV 306
           E++ ++
Sbjct: 307 ELIDDI 312


>UniRef50_C6R3Y0 Hydroxymethylbilane synthase n=1 Tax=Rothia mucilaginosa ATCC 25296
           RepID=C6R3Y0_9MICC
          Length = 377

 Score =  198 bits (504), Expect = 2e-49,   Method: Compositional matrix adjust.
 Identities = 142/370 (38%), Positives = 192/370 (51%), Gaps = 73/370 (19%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMA------SHPG------LVVELVPMVTRGDVI 48
           M  +   + TR S LAL Q+    + + +      +H G      +  EL  + T GDV 
Sbjct: 1   MSHHEYTLGTRGSALALTQSRIAAETVTSLYTEHQAHHGAENPEAVSFELRTVKTEGDV- 59

Query: 49  LDTPLAKVGGKGLFVKELEVALL-------ENRADIAVHSMKDVPVEFPQGLGLVTICER 101
           L  PLA +GG G+F   L   LL       ENR D+AVHS+KD+P     GL +    +R
Sbjct: 60  LTGPLATLGGTGVFAAALRQRLLDGENASEENRVDMAVHSLKDLPSAPCPGLVVAATLKR 119

Query: 102 EDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD- 160
           EDPRDA V+ +  ++D LP GS VGT S RR  QL   RPDL I  +RGNVGTR+ ++  
Sbjct: 120 EDPRDALVARDGLTVDTLPEGSRVGTGSPRRAAQLRALRPDLEIVDVRGNVGTRIGRVKG 179

Query: 161 -----------------------------NGEYDAIILAVAGLKRLGLESRIRAALPPEI 191
                                        +G+ DA++LAV+GLKRLG E  I   L P  
Sbjct: 180 LEEHAGKQVVLRQNAETSERADHGVGTERSGDCDAVVLAVSGLKRLGKEELITEYLDPTR 239

Query: 192 SLPAVGQGAVGIECRLDDSRT-------------------RELLAALNHHETALRVTAER 232
            LPA GQGA+ +E R  +                      R LLAA NHHET L V+AER
Sbjct: 240 MLPAPGQGALALEVRESEFENPDSAVLADPEVARPVRALGRALLAA-NHHETRLAVSAER 298

Query: 233 AMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---AEQMGIS 289
           A+  RLE GC  PIG+YA +++G++ L  +V +PDG+ ++R     A  D   AE++G+ 
Sbjct: 299 ALLRRLEAGCAAPIGAYAHVVEGDLVLNVVVASPDGTDMLRHTSATAELDVPGAERLGVR 358

Query: 290 LAEELLNNGA 299
           +AE+LL  GA
Sbjct: 359 VAEDLLQMGA 368


>UniRef50_Q8RFP5 Porphobilinogen deaminase n=16 Tax=Fusobacteriaceae
           RepID=HEM3_FUSNN
          Length = 298

 Score =  198 bits (504), Expect = 2e-49,   Method: Compositional matrix adjust.
 Identities = 118/273 (43%), Positives = 160/273 (58%), Gaps = 5/273 (1%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPL--AKVGG 58
           M  N++ I +R S LAL QA+ VKD+L  ++P L  E+  +VT GD  L +    + +  
Sbjct: 1   MKKNII-IGSRGSILALAQANLVKDRLQGNYPNLSFEIKEIVTSGDKDLKSNWENSDISL 59

Query: 59  KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118
           K  F KE+E  LL+   DIAVHSMKD+P    + L    I +REDPRD  VS N   L  
Sbjct: 60  KSFFTKEIEQELLDGEIDIAVHSMKDMPAVSAKSLICGAIPDREDPRDVLVSKN-GLLVT 118

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178
           LP G+ VGTSSLRR   L   RPD  I+ LRGN+ TRL KL+  +YDAI+LA AGLKR G
Sbjct: 119 LPQGAKVGTSSLRRAMNLKTVRPDFEIKHLRGNIHTRLKKLETEDYDAIVLAAAGLKRTG 178

Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
           L  +I   L  E+  PA  QG + I+CR +D   +E+L ++++   A  V  ER  +   
Sbjct: 179 LADKITEYLNGEVFPPAPAQGVLYIQCRENDEEIKEILKSIHNEAIAKIVEIEREFSKIF 238

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQI 271
           +GGC  P+G Y+++   +I   A V   +G QI
Sbjct: 239 DGGCHTPMGCYSQVNGDKIKFTA-VYLDEGKQI 270


>UniRef50_C9RPT6 Porphobilinogen deaminase n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RPT6_FIBSS
          Length = 351

 Score =  198 bits (503), Expect = 3e-49,   Method: Compositional matrix adjust.
 Identities = 122/280 (43%), Positives = 157/280 (56%), Gaps = 30/280 (10%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHP-------------GLVVELVPMVTRGDV 47
           M D  LRIATR+S LAL Q     D ++A++               L  ELV M T GD 
Sbjct: 1   MSDLKLRIATRKSALALAQTTMAADAIVAANSVIGNAADSNNARDSLTYELVSMTTEGDR 60

Query: 48  ILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDA 107
            LD  LA  GGKG+F+KELE+ALLE RADIA+HS+KD+P E      L  + +REDPRDA
Sbjct: 61  RLDKSLASFGGKGVFIKELEIALLEGRADIAIHSLKDMPAEVLPQFKLAAVLKREDPRDA 120

Query: 108 FVSNNYDS---LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY 164
           F+S    +      LPAG+ VGT S+RR  QL   RPDL    +RGN+ TR+ KL   E 
Sbjct: 121 FLSRGGSAGIRFMDLPAGARVGTGSIRRVVQLKALRPDLEYVPIRGNIQTRIGKL--AEL 178

Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRE---------- 214
           D ++LA AGLKR+GL  ++      E  LPA GQG + IE  L+D+  +E          
Sbjct: 179 DGVVLAAAGLKRMGLADQVTEYFSTEQMLPASGQGILAIET-LNDATVQESRVTGRADLA 237

Query: 215 -LLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELI 253
            +LA +N   T    +AE A    L  GCQ P+ S+AE +
Sbjct: 238 QILARVNDVATYCIASAEMAYLKALNAGCQFPVASFAEFV 277


>UniRef50_A4CHM3 Porphobilinogen deaminase n=4 Tax=Bacteroidetes RepID=A4CHM3_9FLAO
          Length = 315

 Score =  197 bits (502), Expect = 3e-49,   Method: Compositional matrix adjust.
 Identities = 129/322 (40%), Positives = 171/322 (53%), Gaps = 25/322 (7%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   LRI TR S LALWQA  V+D+L A+  G   ELVP+ + GD++LD PL ++G  G+
Sbjct: 1   MSRALRIGTRDSELALWQAQTVRDRLEAA--GHRAELVPVKSTGDLVLDKPLYELGITGI 58

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F K L+VALL    D+AVHSMKDVP   P+G+    + ER   RD  V      LD    
Sbjct: 59  FTKTLDVALLREDIDLAVHSMKDVPTALPEGICQAAVLERASARDVLVHKGLGFLDG--P 116

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+I  T SLRR+ Q   R P   +  LRGNV TRL  L    +D  I A AGL+R+GL  
Sbjct: 117 GTIA-TGSLRRKAQWLNRYPAHQVTGLRGNVNTRLKLLRENSWDGAIFAQAGLERIGLLP 175

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
               A P +  LPA  QGA+ +  R  D+  RE    L+H ++AL V  ER     LEGG
Sbjct: 176 --DNAEPLDWMLPAPAQGAMLVVARTSDTAAREAARPLHHEQSALEVAVEREFLRTLEGG 233

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAP-----------QDAEQMGISL 290
           C  PIG+     DG++ L   + + DG +  R  R               QDA + G + 
Sbjct: 234 CSAPIGARVHAADGQLHLEGGLFSLDGKKAFRVTRHTGSLEAGGTGDARFQDAGEFGAAC 293

Query: 291 AEELLNNGA-------REILAE 305
           A E+L++G        R+ILA+
Sbjct: 294 AREILDSGGAVLMESIRKILAQ 315


>UniRef50_D2NS36 Porphobilinogen deaminase n=2 Tax=Micrococcaceae RepID=D2NS36_9MICC
          Length = 454

 Score =  197 bits (501), Expect = 4e-49,   Method: Compositional matrix adjust.
 Identities = 142/363 (39%), Positives = 187/363 (51%), Gaps = 73/363 (20%)

Query: 8   IATRQSPLALWQAHYVKDKLM-------ASHPGLVVELVPMV-----TRGDVILDTPLAK 55
           + TR S LAL Q+    + +        A H     E+V        T GDV L  PLA 
Sbjct: 85  LGTRGSALALTQSRIAAETVTSLYTEHQAHHGAADAEVVDFTLRTVKTEGDV-LTGPLAT 143

Query: 56  VGGKGLFVKELEVALL-------ENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAF 108
           +GG G+F   L   LL       ENR D+AVHS+KD+P     GL +    +REDPRDA 
Sbjct: 144 LGGTGVFAAALRQRLLDGENASEENRVDMAVHSLKDLPSAPCPGLVIAATLKREDPRDAL 203

Query: 109 VSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD-------- 160
           V+ +  +LD LP GS VGT S RR  QL   RPDL I  +RGNVGTR+ ++         
Sbjct: 204 VARDGLTLDTLPEGSRVGTGSPRRAAQLRALRPDLEIVDIRGNVGTRIGRVKGLEEHAGK 263

Query: 161 ----------------------NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQ 198
                                 +G+ DA++LAV+GLKRLG E  I   L P   LPA GQ
Sbjct: 264 QVVLRQNTETSERADHGVGTERSGDCDAVVLAVSGLKRLGKEELITEYLDPTRMLPAPGQ 323

Query: 199 GAVGIECRLDDSRT-------------------RELLAALNHHETALRVTAERAMNTRLE 239
           GA+ +E R  +                      R LLAA NHHET L V+AERA+  RLE
Sbjct: 324 GALALEVRESEFENPDPAVLADPEVARPVRALGRALLAA-NHHETRLAVSAERALLRRLE 382

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---AEQMGISLAEELLN 296
            GC  PIG+YA +++G++ L  +V +PDG+ ++R     A  D   AE++G+ +AE+LL 
Sbjct: 383 AGCAAPIGAYAHVVEGDLVLSVVVASPDGTDMLRHTSATAELDVPGAERLGVRVAEDLLQ 442

Query: 297 NGA 299
            GA
Sbjct: 443 MGA 445


>UniRef50_Q7UPN0 Porphobilinogen deaminase n=1 Tax=Rhodopirellula baltica
           RepID=HEM3_RHOBA
          Length = 337

 Score =  197 bits (501), Expect = 4e-49,   Method: Compositional matrix adjust.
 Identities = 132/325 (40%), Positives = 189/325 (58%), Gaps = 27/325 (8%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LRIATR+SPLA+WQA +V  KL+  H G   E+VP+V++GD  +  P+      GLF K 
Sbjct: 12  LRIATRESPLAMWQAEHVA-KLLKKH-GFQTEIVPLVSKGDTDM-RPIDGTRQVGLFTKR 68

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV----SNNYDS------ 115
           ++ AL+++ AD+AVHS+KD+P E      L  +  RE   DA V    S + +S      
Sbjct: 69  IQQALVDDEADVAVHSLKDLPTEPDSRFVLAAVPPRESVLDALVFADNSPHLESQTGAES 128

Query: 116 -LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174
            LD LP G+ VGT S RR  QL + RPDL +  +RGNV TRL+KL+ GE+DAI+LA AG+
Sbjct: 129 PLDYLPQGARVGTGSTRRLAQLKQLRPDLEVLPIRGNVQTRLAKLNAGEFDAIVLAHAGI 188

Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234
            RL +        P +  +PA GQGA+GIE R DD+   + +A LN     L  TAER +
Sbjct: 189 LRLEMTDLPHRLFPLDEMIPAPGQGALGIEVRSDDAGAMDAIANLNDAAARLAATAERKV 248

Query: 235 NTRLEGGCQVPIGSYAELIDG----EIWLRALVGAPDGSQIIRGERRGAPQ--------- 281
            + L GGC  PI  +A+L       E+ LRA+V + DG Q ++ + R   Q         
Sbjct: 249 LSELHGGCLAPIACHAKLETSNHGTELCLRAIVMSADGEQRLQEDARITVQPNDADLHVA 308

Query: 282 DAEQMGISLAEELLNNGAREILAEV 306
           +A ++G  +A+ L + GA ++++ V
Sbjct: 309 EAHELGTLVAKRLRDKGADKLISTV 333


>UniRef50_B5G8F1 Porphobilinogen deaminase n=1 Tax=Streptomyces sp. SPB74
           RepID=B5G8F1_9ACTO
          Length = 314

 Score =  196 bits (498), Expect = 8e-49,   Method: Compositional matrix adjust.
 Identities = 129/310 (41%), Positives = 173/310 (55%), Gaps = 13/310 (4%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR SPLAL Q   V   L    P L +E+VP+ T+ D      LA++GGKGLFV+E
Sbjct: 1   MRIGTRSSPLALAQVEQVSGLLRKFEPDLDIEVVPVTTKADK-WQGDLAQLGGKGLFVRE 59

Query: 66  LEVALLENRADIAVHSMKDVP--VEFPQGLGLVTICEREDPRDAFV---SNNYDSLDALP 120
           ++  L   + D+AVH MKDVP  V  P+GL       R+D RD  +    ++  SL  LP
Sbjct: 60  IDQMLQRGQVDMAVHCMKDVPGDVPMPRGLIFAAYLPRDDVRDVLLVPEGSDVQSLAGLP 119

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-----YDAIILAVAGLK 175
            G+ V TS++RR+ Q+   RPDL +  +RG VG+R+ KLD  +      DA++LA AGL+
Sbjct: 120 PGASVATSAVRRKAQINRVRPDLNVVRVRGLVGSRIDKLDGRKPMDHMLDAMVLARAGLE 179

Query: 176 RLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235
           RL L  R R        LPAVG GA+G+ECR DD     LL  LN   T   +TAER M 
Sbjct: 180 RLDLMHRARQVFEVAEMLPAVGAGALGLECREDDDAVAYLLQQLNDEPTMTEITAERVML 239

Query: 236 TRLEGGCQVPI-GSYAELIDGEIWLRALVGAPDGSQIIRGERRG-APQDAEQMGISLAEE 293
             L G C  PI G      DG++ LR +V + DGS+ +     G +  D   +G  +  E
Sbjct: 240 HGLRGHCNSPIAGHCVTDPDGQLSLRGMVFSRDGSKFVHAHFWGESMNDPAVLGSRVCAE 299

Query: 294 LLNNGAREIL 303
           LL  GAR+I+
Sbjct: 300 LLRQGARDII 309


>UniRef50_C6XGK7 Porphobilinogen deaminase n=1 Tax=Candidatus Liberibacter asiaticus
           str. psy62 RepID=C6XGK7_LIBAP
          Length = 307

 Score =  196 bits (498), Expect = 9e-49,   Method: Compositional matrix adjust.
 Identities = 112/291 (38%), Positives = 161/291 (55%), Gaps = 2/291 (0%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
            RI TR SPLAL  A   +  LM  H  P   + ++P+ T+GD I +  L ++GGKGLF 
Sbjct: 6   FRIGTRCSPLALAHAFETRSSLMDVHKIPPHNIVIIPLSTKGDRITNRTLTEIGGKGLFT 65

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           +E+E  L+    D AVHS KD+P +  +GL +     RED RD F+S+   SL  L   S
Sbjct: 66  EEIEKKLISGEIDCAVHSAKDMPTKLLKGLQISAYLPREDIRDVFISHTAQSLKDLALHS 125

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           ++GTSSLRR+  L   R D+ +   RG + TRL+KL+N +  AI+LA AG+KRL  E  I
Sbjct: 126 VIGTSSLRRKALLLRWRSDISVIDFRGKIETRLNKLNNNKAHAILLAYAGIKRLKKEKVI 185

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
           +  L  E   P+ GQGA+ IE  +++ + +EL+  +NH +T   V  ERA    L+G C+
Sbjct: 186 KEILNIEDFPPSPGQGAICIETHVNNPKAQELVKVINHEDTWDSVNCERAFLAELDGSCK 245

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
             I  +A      ++   +V A DG       R G   DA  +G   A+ +
Sbjct: 246 SAIAGFAYCKGSTLYFYGIVLASDGKIFHEVSRNGNRCDAINIGRDAAQYI 296


>UniRef50_UPI0001926E0E PREDICTED: similar to hydroxymethylbilane synthase, partial n=1
           Tax=Hydra magnipapillata RepID=UPI0001926E0E
          Length = 418

 Score =  196 bits (498), Expect = 1e-48,   Method: Compositional matrix adjust.
 Identities = 111/269 (41%), Positives = 150/269 (55%), Gaps = 4/269 (1%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67
           + +R+S LA+ Q   +   L      +   +  M T GD IL   L K+G K LF K+LE
Sbjct: 33  VGSRKSQLAVIQTKSIVAALCQKEKDVECIIETMDTLGDKILHIALPKIGEKSLFTKDLE 92

Query: 68  VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDSLDALPAGSI 124
           +AL E R D  VHS+KD+P   PQG+ + TI +R+DPRD  +    +N   L  LP  SI
Sbjct: 93  LALSEKRVDFLVHSLKDLPTTLPQGMAISTIYKRDDPRDCIIFHPKHNGKKLADLPENSI 152

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-YDAIILAVAGLKRLGLESRI 183
           +GTSSLRR  QL  +   L  +S+RGN+ TRL KL+    YDAI+LA AG+ R+G   +I
Sbjct: 153 IGTSSLRRVAQLKRKYNKLTFQSVRGNLNTRLQKLEEESLYDAIVLAKAGVDRMGWTEKI 212

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              L  +  L A+GQGA+ +E R DD  T  +LA L   ET L   AER     L GGC 
Sbjct: 213 GQILSEDECLYAIGQGAITVEVRNDDKYTISILAQLTDMETLLACVAERCFMRTLNGGCS 272

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQII 272
            PI  +++       LR +V   DGS+ +
Sbjct: 273 TPIACHSQFSGNNYSLRGIVLNADGSRFL 301


>UniRef50_C3WGN0 Porphobilinogen deaminase n=5 Tax=Fusobacterium RepID=C3WGN0_9FUSO
          Length = 301

 Score =  196 bits (498), Expect = 1e-48,   Method: Compositional matrix adjust.
 Identities = 122/305 (40%), Positives = 172/305 (56%), Gaps = 13/305 (4%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG--KGLFVKE 65
           I +R S LAL QA  VK+ L A++P L  E+  +VT GD  L +         K  F KE
Sbjct: 7   IGSRGSILALAQASLVKNSLEANYPDLTFEIKEIVTSGDKDLKSNWENSNASLKSFFTKE 66

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E  LL+ + DIAVHSMKD+P   P+GL    I +RED RD  +S N   L  LP G+ +
Sbjct: 67  IEQELLDGQIDIAVHSMKDMPAVSPKGLICGAIPDREDARDVLISKN-GFLVTLPQGAKI 125

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSSLRR   L   RPD  I+ LRGN+ TRL KL+  +YDAIILA AGLKR G+  +I  
Sbjct: 126 GTSSLRRVMNLKAIRPDFEIKHLRGNIHTRLKKLETEDYDAIILAAAGLKRTGMADKITE 185

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L  E   PA  QG + I+CR +D   + +L ++++ + A  V  ER  +   +GGC  P
Sbjct: 186 YLSGEAFPPAPAQGVLYIQCRENDEEIKGILKSIHNEDIAKIVEIEREFSKIFDGGCHTP 245

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305
           +G Y+++ + +I   A   + DG QI     R   +D     ++  +E+ +  A EI A+
Sbjct: 246 MGCYSQVDEDKIKFIAAY-SHDGKQI-----RVVIED----DLTKGKEIAHMAAEEIKAK 295

Query: 306 VYNGD 310
           +  G+
Sbjct: 296 INKGN 300


>UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia (class)
           RepID=B9L0Q4_THERP
          Length = 560

 Score =  195 bits (496), Expect = 1e-48,   Method: Compositional matrix adjust.
 Identities = 125/289 (43%), Positives = 162/289 (56%), Gaps = 4/289 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI +R S LAL Q   V ++L    P   V +VP+VT GD    T L  +GG G+F KE
Sbjct: 5   IRIGSRGSTLALAQTEEVVERLRRLVPECSVTVVPIVTTGDRDRATSLTVLGGSGVFAKE 64

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L  ALL    D+AVHS KD+P + P GL LV +  RED RD  V++    L  LPAG+ V
Sbjct: 65  LHEALLAGTIDLAVHSAKDLPTQLPPGLVLVAVLAREDARDVLVTSPPRKLGELPAGARV 124

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS RRQ  L   RPDLI+  +RGNV TRL KL  G  DA++L  AGL+RL     +  
Sbjct: 125 GTSSRRRQALLQRARPDLIVVDIRGNVDTRLRKLREGIVDALVLGAAGLRRLSQADLVAE 184

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L P+  +PA GQGA+ +  R  D R  ELL+ L+       V  ERA       GC VP
Sbjct: 185 YLDPDEFVPAPGQGALAVVARESDGRL-ELLSRLDEPLVHEAVAVERAFLAAFGSGCSVP 243

Query: 246 IGSYAELIDGEIWLRALVGAPDG---SQIIRGERRGAPQDAEQMGISLA 291
           +G+YA +    +  R  V  PDG   SQ +   R  A + A ++G++LA
Sbjct: 244 LGAYATIAGNRLRFRIAVLLPDGRFISQCLDWPREEAIERARELGLTLA 292


>UniRef50_C6XST0 Porphobilinogen deaminase n=2 Tax=Pedobacter RepID=C6XST0_PEDHD
          Length = 526

 Score =  194 bits (494), Expect = 3e-48,   Method: Compositional matrix adjust.
 Identities = 119/264 (45%), Positives = 159/264 (60%), Gaps = 16/264 (6%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L I TR S LALWQA+++KDKL A   G+  EL  + T+GD IL+  L K+ GKG F KE
Sbjct: 4   LIIGTRGSDLALWQANFIKDKLAAI--GVEAELKIIKTQGDKILNLRLDKLEGKGFFTKE 61

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAF------VSNNYDSLDAL 119
           LE  LL    DIAVHS KD+P   P GL +  + EREDP +        VS N+    +L
Sbjct: 62  LEEELLGGTIDIAVHSHKDLPTVHPAGLTIAAVTEREDPSELLLILKDCVSINHKL--SL 119

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179
             G++VGTSS RR+ QL   RPDL I  LRGNV TR+ KL + +YDAI+LA AG+ RL +
Sbjct: 120 KKGAMVGTSSNRRKAQLLALRPDLNIEDLRGNVPTRIQKLRDEDYDAILLARAGVNRLNI 179

Query: 180 ---ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236
              E  +      E+ +PA  QGA+ I+ R +++   ++L  +NH ETA  +  ER +  
Sbjct: 180 DLSEFHVEVVDTTEL-VPAPAQGALAIQIRENENELFDILQQINHSETAEEIAIERKVLN 238

Query: 237 RLEGGCQVPIGSYAELIDG--EIW 258
             EGGC +P+G Y +  DG  E+W
Sbjct: 239 LFEGGCHMPLGCYCKKEDGQYEVW 262


>UniRef50_C5RMN3 Porphobilinogen deaminase n=1 Tax=Clostridium cellulovorans 743B
           RepID=C5RMN3_CLOCL
          Length = 300

 Score =  194 bits (493), Expect = 3e-48,   Method: Compositional matrix adjust.
 Identities = 121/310 (39%), Positives = 175/310 (56%), Gaps = 16/310 (5%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +  ++RI TR+S LAL Q + V D +   HP +  E+V M T+GD ILD  L   GGKG 
Sbjct: 1   MKKIIRIGTRKSKLALMQTNIVIDAIKKKHPEINCEVVEMSTKGDEILDKSLLSFGGKGA 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS-NNYDSL-DAL 119
           FV E E A+     D+AVHS KD+P++   GL +V + +REDPRD  V+ NN D++ D  
Sbjct: 61  FVSEFEKAIKSGEIDLAVHSAKDMPMDLLTGLKIVAVTKREDPRDVLVTANNKDTINDFN 120

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179
               ++GT+SLRR+ Q+     ++  + LRGNV  RL KL +GEYD IILA AGLKRLGL
Sbjct: 121 KTNKLIGTTSLRRKLQIKRLLNNVDTKDLRGNVQRRLEKLISGEYDGIILAAAGLKRLGL 180

Query: 180 --ESRIR-AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236
             + RI    L  E  +PA GQG + +E R ++  +  L  ++++ E    +  ER +  
Sbjct: 181 LDDERINLNYLSVEDFIPAGGQGIIAVEGRAEEEFSF-LKDSIHNEEAMYSLEVERYVMK 239

Query: 237 RLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
           +L  GC  PIG+Y+  ID +     ++   +G        R    D+ +  + L E+L+ 
Sbjct: 240 KLNAGCNEPIGAYS-FIDKDTIFLDIIYEHNGKV-----SRKKGSDSIENRLKLTEKLV- 292

Query: 297 NGAREILAEV 306
               EIL EV
Sbjct: 293 ---EEILQEV 299


>UniRef50_P28789 Porphobilinogen deaminase n=18 Tax=Saccharomycetales
           RepID=HEM3_YEAST
          Length = 327

 Score =  194 bits (493), Expect = 3e-48,   Method: Compositional matrix adjust.
 Identities = 122/317 (38%), Positives = 178/317 (56%), Gaps = 15/317 (4%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            L I  R+S LA+ Q+++V   +   +P    ++  + T GD I   PL   GGK L+ K
Sbjct: 5   TLHIGGRKSKLAVIQSNHVLKLIEEKYPDYDCKVFTLQTLGDQIQFKPLYSFGGKALWTK 64

Query: 65  ELEVALLEN----RADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDSLD 117
           ELE  L  +    + D+ VHS+KD+P   P+G  L  I +R DP D  V    + Y SLD
Sbjct: 65  ELEDHLYHDDPSKKLDLIVHSLKDMPTLLPEGFELGGITKRVDPTDCLVMPFYSAYKSLD 124

Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAGLK 175
            LP G IVGTSS+RR  QL  + P L   S+RGN+ TRL KLD+ +  Y  IILA AGL 
Sbjct: 125 DLPDGGIVGTSSVRRSAQLKRKYPHLKFESVRGNIQTRLQKLDDPKSPYQCIILASAGLM 184

Query: 176 RLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235
           R+GLE+RI      +    AVGQGA+GIE R  D++  ++L  +      +   +ERA+ 
Sbjct: 185 RMGLENRITQRFHSDTMYHAVGQGALGIEIRKGDTKMMKILDEICDLNATICCLSERALM 244

Query: 236 TRLEGGCQVPIGSYAELID--GEIWLRALVGAPDGSQIIRGE----RRGAPQDAEQMGIS 289
             LEGGC VPIG  ++  +   ++ L+A+V   +G++ +  E         +D+   G  
Sbjct: 245 RTLEGGCSVPIGVESKYNEETKKLLLKAIVVDVEGTEAVEDEIEMLIENVKEDSMACGKI 304

Query: 290 LAEELLNNGAREILAEV 306
           LAE ++ +GA++IL E+
Sbjct: 305 LAERMIADGAKKILDEI 321


>UniRef50_Q09899 Porphobilinogen deaminase n=2 Tax=Schizosaccharomyces
           RepID=HEM3_SCHPO
          Length = 336

 Score =  192 bits (489), Expect = 1e-47,   Method: Compositional matrix adjust.
 Identities = 126/314 (40%), Positives = 179/314 (57%), Gaps = 16/314 (5%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG---GKGLFVK 64
           I TR+S LA+ Q+  ++++L   +P L   ++   T GD IL   L +      K L+ +
Sbjct: 9   IGTRKSKLAVIQSEIIREELEKHYPHLEFPIISRDTIGDEILSKALFEFKRQLAKSLWTR 68

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDSLDALPA 121
           ELE  L+ N+  I VHS+KD+P E P G+ +  I +R  P DA V    ++Y ++  LP 
Sbjct: 69  ELEALLVTNQCRILVHSLKDLPSEMPDGMVIACIPKRSCPLDAIVFKAGSHYKTVADLPP 128

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLKRLGL 179
           GS+VGTSS+RR+  LA   P L    +RGNVGTRL+KLD  + ++D ++LA AGL RLGL
Sbjct: 129 GSVVGTSSIRRRALLARNFPHLRFVDIRGNVGTRLAKLDAPDSQFDCLVLAAAGLFRLGL 188

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
           + RI   L       AVGQGA+ +E R DD    E+L  L H ET     AERA+  RL+
Sbjct: 189 KDRIAQMLTAPFVYYAVGQGALAVEVRADDKEMIEMLKPLQHQETLYACLAERALMKRLQ 248

Query: 240 GGCQVPIGSYAELI-----DGEIWLRALVGAPDGSQIIRGE---RRGAPQDAEQMGISLA 291
           GGC +PIG   +++        I L   V + DG +   G       + ++AE++GI++A
Sbjct: 249 GGCAIPIGVQTDVLAISNSSYRISLLGTVLSADGLRAAFGNAEAVVSSEEEAEELGITVA 308

Query: 292 EELLNNGAREILAE 305
             LL NGA  IL E
Sbjct: 309 LALLKNGAGPILEE 322


>UniRef50_A0DD68 Chromosome undetermined scaffold_46, whole genome shotgun sequence
           n=2 Tax=Paramecium tetraurelia RepID=A0DD68_PARTE
          Length = 306

 Score =  192 bits (487), Expect = 2e-47,   Method: Compositional matrix adjust.
 Identities = 119/275 (43%), Positives = 159/275 (57%), Gaps = 10/275 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTR-GDVILDTPLAKVGGKGLFVK 64
           LRIATR S LA+ Q +YV  +L         E++ +    GDV L  PL ++   G+F K
Sbjct: 5   LRIATRSSALAMAQTNYVISELKQE-----CEIIKVSNEVGDVNLQDPLYQMPTVGVFTK 59

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALPA 121
           ++E  LLE +AD+AVHS+KD+P      L L    + E   D  + N   NY SL  LP 
Sbjct: 60  QVEQYLLEQKADVAVHSLKDLPTIIDAQLHLAAYTKFEQRGDVVLLNKKYNYKSLSELPD 119

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G  VGTSSLRR   +  R P L + ++RGN+ TR+ KLD G+YDAIILA AG+ RLGL  
Sbjct: 120 GLKVGTSSLRRIATIRSRYPKLNLINIRGNLNTRIQKLDEGQYDAIILAKAGILRLGLAE 179

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
           +I   L  +  L A  Q A+GI+CR DD  T   L  LN  +   R  AER     LEGG
Sbjct: 180 KISFDLDEKEFLYAPAQAALGIQCRKDDLETIGRLQILNDTDAQKRCVAERMFLNLLEGG 239

Query: 242 CQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGE 275
           C++PI  Y+E   DG+++++  V A DGS++I  E
Sbjct: 240 CRLPIAVYSECREDGQVYIKGRVLAVDGSKVIEDE 274


>UniRef50_A8MGE4 Porphobilinogen deaminase n=30 Tax=cellular organisms
           RepID=HEM3_ALKOO
          Length = 296

 Score =  191 bits (485), Expect = 3e-47,   Method: Compositional matrix adjust.
 Identities = 114/291 (39%), Positives = 162/291 (55%), Gaps = 9/291 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +R+ +R+S LA+ Q+  V + +    P + +ELV M T GD+ LD  L K+GGKGLF+KE
Sbjct: 3   IRVGSRESKLAVKQSEIVIEAIRKYDPNIEIELVTMKTTGDIKLDQTLDKIGGKGLFIKE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L+ AL ++R DI VHS KD+P+   + L +V + +REDPRD  V     ++        +
Sbjct: 63  LDQALYDDRVDITVHSFKDMPMAIDEYLPIVAVSKREDPRDVLVLPK--TVKEPDFSKPI 120

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           G SS RR+ QL E  P   +  +RGNV TRL KLD GE+ AI LA+AGLKRLGLE RI  
Sbjct: 121 GCSSFRRKIQLQEIYPHCSVEPIRGNVLTRLEKLDRGEFSAITLALAGLKRLGLEERISR 180

Query: 186 ALPPEISLPAVGQGAVGIECR--LDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
                  LPA  QG + ++ R   D S     L+  +  E      AER+    L GGC 
Sbjct: 181 IFEVTEILPAACQGVIVVQARKGFDVS----FLSDFHDKEAWDISMAERSFVRTLNGGCS 236

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
            P+ +Y E+ D  + L  L      + + +    GA +  E+MG +LA ++
Sbjct: 237 SPVAAYGEIKDNYLTLTGLY-VDSSNSVHKKTITGARKQGEEMGFNLALQM 286


>UniRef50_C0BZ93 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM
           15053 RepID=C0BZ93_9CLOT
          Length = 298

 Score =  191 bits (485), Expect = 3e-47,   Method: Compositional matrix adjust.
 Identities = 121/294 (41%), Positives = 164/294 (55%), Gaps = 7/294 (2%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           + +++RI +R+S LA+ QA  VK  +  + P +  E+V M T GD ILD  L   GGKGL
Sbjct: 1   MQSIIRIGSRESRLAVKQAEIVKQAVERNCPDIKAEIVTMKTEGDKILDRRLELAGGKGL 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FVKELE ALL+ R DI VHS+KDVP+E P+ L +V   EREDPRD  +     +  ++P 
Sbjct: 61  FVKELEKALLDGRIDICVHSLKDVPMEVPEDLPVVAFGEREDPRDVLIYKPGRT--SIPE 118

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G ++GTSS RR+ QL    P    RS+RGNV TRL KL    +D  +LA AGLKRL +E 
Sbjct: 119 GGVIGTSSRRRELQLKRLYPSCTFRSIRGNVQTRLRKLSEEGFDGTVLAAAGLKRLHMEE 178

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
                   +  +PAVGQG + ++ R    R    L +    ++     AER     L GG
Sbjct: 179 VAGRVFSVDEIIPAVGQGILAVQGR--KGRDYSWLTSFACGKSRAEAEAEREFAAALGGG 236

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD-AEQMGISLAEEL 294
           C  P+ ++A+    E+ L  L     G  I R   R    D A Q+G +LAEE+
Sbjct: 237 CTSPVAAHAQAQGAELKLTGLYYC--GGDIYRTRTRTGETDRARQLGAALAEEM 288


>UniRef50_Q1AUK3 Porphobilinogen deaminase n=1 Tax=Rubrobacter xylanophilus DSM 9941
           RepID=HEM3_RUBXD
          Length = 305

 Score =  191 bits (485), Expect = 3e-47,   Method: Compositional matrix adjust.
 Identities = 121/266 (45%), Positives = 160/266 (60%), Gaps = 3/266 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L + TR SPLAL QA      L A+  G  VEL  + T  D   D PL+ +  + +F ++
Sbjct: 5   LVLGTRGSPLALAQAEACAAGLRAA--GFAVELRRIRTTSDRRPDDPLSVIDQRDVFTRQ 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L+ ALL    D+AVHSMKDVP E P+G+ L  +  R DP DA VS     +D LP G+ V
Sbjct: 63  LDEALLAGEVDLAVHSMKDVPTEVPEGIVLAAVAGRADPSDALVSEGGWGVDGLPEGARV 122

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
            TSSLRR+ QL  RRPDL +  +RGNV TR+ K+  G  +A++LA AGL RLGLE    A
Sbjct: 123 ATSSLRRRAQLLHRRPDLRVVEIRGNVDTRIRKMRAGAAEAVVLARAGLVRLGLEV-PHA 181

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            +P ++ LPAVGQGA+ +  R  D R  E+  ALN       V AERA+   LEGGC+VP
Sbjct: 182 VIPHDVLLPAVGQGALAVAVRRGDPRLEEIRRALNDPAAEREVAAERALLRALEGGCRVP 241

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQI 271
           +G+ A      + LR +V +PDG+ +
Sbjct: 242 VGARAVAGGRGVLLRGVVVSPDGAAL 267


>UniRef50_C1TM53 Porphobilinogen deaminase n=1 Tax=Dethiosulfovibrio peptidovorans
           DSM 11002 RepID=C1TM53_9BACT
          Length = 454

 Score =  191 bits (484), Expect = 3e-47,   Method: Compositional matrix adjust.
 Identities = 118/262 (45%), Positives = 153/262 (58%), Gaps = 6/262 (2%)

Query: 10  TRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVA 69
           +R+S LA  +A  ++     +  GL VE+  M T GD   D  L+  GG G FVK LE A
Sbjct: 160 SRKSALA--RAQTMEAARALAKKGLPVEIKTMSTCGDEKQDCHLSAFGGNGAFVKCLEEA 217

Query: 70  LLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSS 129
           ++E + D A+HS+KDVP   P GL LV +  R    D  VSN+   L+ LPAG++VGTSS
Sbjct: 218 IMEGKGDGAIHSLKDVPSVLPDGLELVAVLPRASTSDVIVSNHKGGLEGLPAGAVVGTSS 277

Query: 130 LRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPP 189
           LRR+ QLA  RPDL    +RGNV TRL+KL +G+ DAI+LA AGL RLG+       LP 
Sbjct: 278 LRRKAQLAITRPDLDYTLIRGNVNTRLAKLQSGDADAIVLAKAGLDRLGISPEGATTLP- 336

Query: 190 EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSY 249
              LPA  QG + +E R   SR  E   A+NH  T L   AER +   L+ GC VP  + 
Sbjct: 337 --FLPAPCQGIIAVEAR-SGSRLAEEFRAINHRPTWLMALAERELLESLQVGCHVPFAAL 393

Query: 250 AELIDGEIWLRALVGAPDGSQI 271
           +E + GE+ LRA   + DG  I
Sbjct: 394 SEWVGGELRLRAQTLSYDGRHI 415


>UniRef50_B3RTQ8 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens
           RepID=B3RTQ8_TRIAD
          Length = 314

 Score =  191 bits (484), Expect = 4e-47,   Method: Compositional matrix adjust.
 Identities = 121/335 (36%), Positives = 175/335 (52%), Gaps = 64/335 (19%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M + V+RI TR+S LA+ Q H V D L   HP   +E+V M T GD +LD  L ++G   
Sbjct: 4   MEETVVRIGTRKSQLAMIQTHSVVDALREIHPKARIEIVTMDTIGDRVLDKALPEIGQTN 63

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LF K+LEVAL +N+ D+ +HS+KDVP   P+GL +  I                      
Sbjct: 64  LFTKDLEVALTDNKIDLIIHSLKDVPSTLPEGLAIAAI---------------------- 101

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD-NGEYDAIILAVAGLKRLGL 179
            G+++GTSSLRR  QL  R P L   ++RGN+ TRL KLD +G YDA++LA AG++    
Sbjct: 102 -GNVIGTSSLRRIAQLKRRFPHLKFENVRGNLNTRLKKLDESGIYDALVLAGAGVE---- 156

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
                  L P+  L A+GQGA+GIE R +D +T  L++A    ++ +   AERA    L+
Sbjct: 157 -------LTPDECLYAIGQGALGIEIRKNDKKTFSLISAYTDFDSLVCNAAERAFLRFLD 209

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIR-------------------------- 273
            GC VPIG Y E  + ++ +   V + DGS+ ++                          
Sbjct: 210 KGCSVPIGVYTEFTENKLKITGAVFSLDGSKRVQYSDECTISGLNAKDDCESNYESLSSI 269

Query: 274 ---GERRGAPQDAEQMGISLAEELLNNGAREILAE 305
               E   +  +AE++G  +AE +L N   E+LAE
Sbjct: 270 LCPSEMCNSLIEAERLGKYVAEMILKNHGGEVLAE 304


>UniRef50_B0D5Q2 Predicted protein n=1 Tax=Laccaria bicolor S238N-H82
           RepID=B0D5Q2_LACBS
          Length = 340

 Score =  190 bits (483), Expect = 5e-47,   Method: Compositional matrix adjust.
 Identities = 121/309 (39%), Positives = 170/309 (55%), Gaps = 10/309 (3%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67
           I  R S LA  QA  V+ +L    P    E+         I  + + + GG  L+  ELE
Sbjct: 21  IGCRPSTLAKIQAELVRSRLKVLFPASRFEISSKKFPQPEIGTSQITERGGASLWTTELE 80

Query: 68  VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALPAGSI 124
            AL +   DI VHS+KDVP +  +G  ++ + ERED RD  V  +   Y +L+ LPAGS+
Sbjct: 81  DALFDGDIDILVHSLKDVPTKLKEGCEIIHVLEREDRRDCLVVKDGLPYRTLEELPAGSV 140

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAGLKRLGLESR 182
           VGT S+RR  Q+  R P L+I+ +RGN+ TRL KLD+ +  Y A+ILA AGL RL L  R
Sbjct: 141 VGTGSVRRVAQMKRRYPLLVIKDVRGNIDTRLQKLDSPDLPYTALILASAGLLRLSLHDR 200

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
           I + L P IS PAVGQG +G E R  D++ + +++ L   +    V AERA+   LEGGC
Sbjct: 201 ITSYLSPPISYPAVGQGCLGAEFRSADTKVKAMVSRLEVWQDGWAVRAERALLWVLEGGC 260

Query: 243 QVPIGSYAELIDGEIWLRAL--VGAPDGSQIIRGERRGAPQDAE---QMGISLAEELLNN 297
             P+G ++      I   +L  + +PDGS+ I  E  G     E   ++G   A  LL  
Sbjct: 261 AFPVGIWSSWSGDNIASESLSVMTSPDGSEEITVETTGVVASVEEVLELGKQAARSLLEK 320

Query: 298 GAREILAEV 306
           G R I+ ++
Sbjct: 321 GGRGIIVDL 329


>UniRef50_C4QMG7 Hydroxymethylbilane synthase (Porphobilinogen deaminase, putative)
           n=1 Tax=Schistosoma mansoni RepID=C4QMG7_SCHMA
          Length = 411

 Score =  189 bits (480), Expect = 1e-46,   Method: Compositional matrix adjust.
 Identities = 113/267 (42%), Positives = 154/267 (57%), Gaps = 19/267 (7%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           NV+R+ +R+S LAL Q     + L   +P ++ E+V M T GD ILD  L+K+G K LF 
Sbjct: 8   NVVRVGSRRSNLALLQTGMAVNLLQKQNPHILFEVVEMATVGDKILDVSLSKIGDKSLFT 67

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRD-AFVSNNY--DSLDALP 120
           KELE ALL    D+ VHS+KDVP   P GL L  +  R  P D   ++ +Y    L  LP
Sbjct: 68  KELENALLSGEVDLVVHSLKDVPSTLPSGLVLGCVFARVSPEDVVLMAPHYRGRKLSDLP 127

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--------------NGEYDA 166
            GS VGTS++RR   L  + P L   S+RGN+ TRL+KLD              +  YDA
Sbjct: 128 IGSTVGTSAVRRVATLTRKYPHLKFVSIRGNLNTRLAKLDTPPASKDNCCSGNPSPSYDA 187

Query: 167 IILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETAL 226
           IILA AG++R+G   RI   L    S  AV QGA+  ECRL D+   +LL+ ++    AL
Sbjct: 188 IILAKAGVERMGWSHRIDQVLTD--SFYAVSQGALACECRLVDNFIMDLLSHIHDESAAL 245

Query: 227 RVTAERAMNTRLEGGCQVPIGSYAELI 253
              AER++  +L+GGC +PIG  ++L+
Sbjct: 246 TTIAERSLMRQLDGGCSIPIGVRSDLV 272


>UniRef50_D1BFI8 Hydroxymethylbilane synthase n=4 Tax=Actinomycetales
           RepID=D1BFI8_SANKS
          Length = 312

 Score =  189 bits (480), Expect = 1e-46,   Method: Compositional matrix adjust.
 Identities = 128/311 (41%), Positives = 175/311 (56%), Gaps = 18/311 (5%)

Query: 6   LRIATRQSPLALWQAHYVKDKL--MASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           LRI TR S LAL Q   V D L  +   P   VE+VP+ T GDV+  + L+++GG G+FV
Sbjct: 7   LRIGTRSSLLALTQTGTVADDLRRLTGRP---VEIVPVTTDGDVLTGS-LSQMGGTGVFV 62

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
             L  ALL++R D+AVHS+KD+P     GL  VT   R+DPRDA  S     L  LP G+
Sbjct: 63  TALRAALLDDRCDVAVHSLKDLPTAGVLGLQHVTPV-RQDPRDALCSRAGHRLADLPHGA 121

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--DNGEYDAIILAVAGLKRLGLES 181
            VGT S RR  QL   RPDL +  +RGN+ TRL ++  + G+ DA++LA AGL R+G E 
Sbjct: 122 RVGTGSPRRAAQLRLVRPDLDVVDIRGNIDTRLGRVHPETGDLDAVVLAAAGLNRIGREH 181

Query: 182 RIRAALPPEISLPAVGQGAVGIECRL----DDSRTRELLAALNHHETALRVTAERAMNTR 237
            I   +      PA GQGA+ +E R     +D         L+   T+L V AERA+  R
Sbjct: 182 AITELISVTDMAPAPGQGALAVETRSSLLEEDPVVARAFDQLDDPATSLSVLAERALLAR 241

Query: 238 LEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD-----AEQMGISLAE 292
           LE GC  P+G++A + DG + L A+V  PDGS+ +R  +     D     A  +G ++A+
Sbjct: 242 LEAGCAAPVGTHATVSDGLLTLHAVVARPDGSEQLRHNQSTEVADTSTAEAVALGEAVAD 301

Query: 293 ELLNNGAREIL 303
             L  GA   +
Sbjct: 302 HFLALGAASFI 312


>UniRef50_Q4T5L1 Chromosome undetermined SCAF9206, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4T5L1_TETNG
          Length = 385

 Score =  189 bits (479), Expect = 1e-46,   Method: Compositional matrix adjust.
 Identities = 139/377 (36%), Positives = 189/377 (50%), Gaps = 85/377 (22%)

Query: 13  SPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLE 72
           S LA  Q   V +KL   +P + +E+V M T GD ILDT L+K+G K LF KELE AL  
Sbjct: 1   SQLARIQTDSVAEKLKELYPDVHLEIVAMSTTGDKILDTALSKIGEKSLFTKELENALER 60

Query: 73  NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDSLDALPAGSIVGTSS 129
           N  D+ VHS+KD+P   P G  +  + +RE+P DA V    N   +LDALPA S++GTSS
Sbjct: 61  NEVDLVVHSLKDLPTSLPPGFTIGAVLKRENPHDAVVLHPKNAGKTLDALPAHSVIGTSS 120

Query: 130 LRRQCQLAERRPDLII------------------------RSLRGNVGTRLSKLDNGE-Y 164
           LRR  QL +R P L                          RS RGN+ TRL KLD  E +
Sbjct: 121 LRRAAQLKKRFPHLDFKDIVSSERCFLPVQPGHRCFFLSSRSQRGNLNTRLKKLDEKEDF 180

Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224
            AIILA AGL+R+G ++RI   L PE  + AVGQGA+ +E R  D+   E+++ L+  +T
Sbjct: 181 AAIILAAAGLRRMGWDNRISQILEPEDCMYAVGQGALAVEVRAKDADILEMVSVLHDPDT 240

Query: 225 ALRVTAERAMNTRL----------------------------EGGCQVPIGSYAELIDGE 256
            LR  AERA    L                            EGGC VP+  + ++ D +
Sbjct: 241 VLRCIAERAFLKHLVQHTHTHTHTHTHTRSLAVAHWNLFCLQEGGCSVPVAVHTKVKDSQ 300

Query: 257 IWLRALVGAPDGSQIIRGERR---GAPQD--------------------------AEQMG 287
           ++L   V + DGS  ++   +    AP D                          AE++G
Sbjct: 301 LYLTGAVYSLDGSDSLKETMQTSVAAPADGSPDEVDECARVGVTANKIPGEAQDRAERLG 360

Query: 288 ISLAEELLNNGAREILA 304
           + LA+ LL+ GA+EIL 
Sbjct: 361 VDLAKLLLSKGAKEILT 377


>UniRef50_UPI00006CBE06 porphobilinogen deaminase family protein n=1 Tax=Tetrahymena
           thermophila RepID=UPI00006CBE06
          Length = 362

 Score =  188 bits (477), Expect = 2e-46,   Method: Compositional matrix adjust.
 Identities = 126/332 (37%), Positives = 178/332 (53%), Gaps = 32/332 (9%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMA-SHPGLV---VELVPM-------------------- 41
            +IA+R S LAL Q + V D L+     GL     E+VP+                    
Sbjct: 21  FKIASRSSQLALSQTYEVIDLLVGVKELGLTKENFEVVPISNAPGKNCTLKFKINITNKQ 80

Query: 42  -VTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICE 100
              +GD  L  PL  +GG G+F K +EV LL    DIAVHS+KD+P    + L +  +  
Sbjct: 81  FTNKGDQNLKDPLYVMGGVGVFTKIVEVELLNKNGDIAVHSLKDLPTIIDERLFIGAVPP 140

Query: 101 REDPRDAFVSNNYDS---LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLS 157
            +   D  + N       L  LP GS++GTSSLRR   L  R P L   ++RGN+ TRL+
Sbjct: 141 LKPRGDVVIFNEKHKGKELKDLPEGSVIGTSSLRRITNLKNRYPHLKYENIRGNLNTRLT 200

Query: 158 KLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLA 217
           KL+NG+YDAIILA AG+ RLG   ++   L  E  L A GQGA+G++CR DD     LL+
Sbjct: 201 KLENGQYDAIILAEAGVFRLGWIEKVGQFLKQEDFLYAPGQGALGVQCRADDKEAIALLS 260

Query: 218 ALNHHETALRVTAERAMNTRLEG---GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRG 274
            +N  E  +RV AER    +LEG   GC++PI  ++E+ID  + L   V + +  + IR 
Sbjct: 261 YINQKEPRIRVDAERQFLNKLEGVILGCKLPIAVHSEIIDQTLRLTGQVWSLEADKTIRE 320

Query: 275 ERRGAPQDAEQMGISLAEELLNNGAREILAEV 306
              G   D + +G+ L+E++   GA EIL ++
Sbjct: 321 VIEGHISD-QDLGLKLSEKMKQAGAGEILEKI 351


>UniRef50_B8MVK7 Porphobilinogen deaminase, putative n=1 Tax=Talaromyces stipitatus
           ATCC 10500 RepID=B8MVK7_TALSN
          Length = 413

 Score =  187 bits (475), Expect = 4e-46,   Method: Compositional matrix adjust.
 Identities = 125/338 (36%), Positives = 172/338 (50%), Gaps = 40/338 (11%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVT------RGDVILDTPLAKVG 57
             +R+ +R S +AL Q   V   L  +H G      P+ T      R        LAK  
Sbjct: 72  KAVRVGSRNSKMALIQTSSVAAALYKAHHGFFT--FPVSTHSVQGDRDKTSAFRDLAKAH 129

Query: 58  G---------KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAF 108
           G         K L+  E+E  LL    D+ VHS+KDVP   P G  +     R DP DA 
Sbjct: 130 GNKQTAADTAKSLWTLEIEARLLAGDIDLIVHSLKDVPTTLPDGCEIGAFPHRNDPTDAL 189

Query: 109 VSNN---YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGE 163
           +      Y SL+ LPAGS+VGT S+RR  QL    P LII+  RGNV TR++KLD  +  
Sbjct: 190 LVKAGLPYKSLEELPAGSVVGTCSVRRTAQLRHYCPHLIIQECRGNVDTRVAKLDANDSP 249

Query: 164 YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHE 223
           Y AI++A AG+ RL LE RI   L       AVGQGA+GIE R +D + REL+A ++H  
Sbjct: 250 YTAIVVAAAGIVRLNLEHRITQRLSGPAYTYAVGQGALGIEIRKEDQKARELVACIDHWP 309

Query: 224 TALRVTAERAMNTRLEGGCQVPIGSYAELI---------------DGEIWLRALVGAPDG 268
           T +R  AERA+   L+GGC  PIG ++  +               +G ++L   +  PDG
Sbjct: 310 TRVRCLAERALLRFLQGGCSAPIGVHSAFVRTPAKGEPNVNDNHYEGTLYLTGTLLHPDG 369

Query: 269 SQIIRGERRG---APQDAEQMGISLAEELLNNGAREIL 303
              IR   +G      D+E +G S+ +++L+ G  +IL
Sbjct: 370 GMEIRAHEKGQVKCTADSETIGKSVGKKILDLGGAQIL 407


>UniRef50_B9XN63 Porphobilinogen deaminase n=1 Tax=bacterium Ellin514
           RepID=B9XN63_9BACT
          Length = 332

 Score =  187 bits (475), Expect = 4e-46,   Method: Compositional matrix adjust.
 Identities = 121/290 (41%), Positives = 160/290 (55%), Gaps = 36/290 (12%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG---KGLFVK 64
           IATR S LAL QA+ V  +  ++ P L +EL  + T GD +    LAK G    KGLF K
Sbjct: 11  IATRGSALALAQANAVLSQCRSAFPKLDIELKIIKTTGDKLQKASLAKEGESLPKGLFTK 70

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA------ 118
           ELEVALL   ADIAVHS+KD+P E P GL L  + +R D RD  V  + + L +      
Sbjct: 71  ELEVALLNGDADIAVHSLKDLPTELPTGLILGAVSKRADVRDVLVYRDAEYLRSQPGKSN 130

Query: 119 ------------LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG-EYD 165
                        P G+ V TSS RR+ QL  +R DL +  +RGNV TRL KL N  E D
Sbjct: 131 RRGFTPKLAIKDFPPGATVATSSTRRKAQLLAQRGDLNVVEIRGNVATRLEKLANQPELD 190

Query: 166 AIILAVAGLKRLGL--------------ESRIRAALPPEISLPAVGQGAVGIECRLDDSR 211
           A +LA AGL+RL                E  +   L  ++ LP VGQ A+G+E R +D+R
Sbjct: 191 ATVLAAAGLERLNFKITAEGKLAGEGIPEGLLATILDFDVMLPCVGQAALGMEIRENDAR 250

Query: 212 TRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRA 261
            +E+   LNH ET   V AER+  + + GGCQ P+ +YAE+   ++ +RA
Sbjct: 251 IQEICDRLNHPETHACVLAERSFLSGMGGGCQSPVAAYAEIAGDQLQMRA 300


>UniRef50_C4ZFT9 Porphobilinogen deaminase n=1 Tax=Eubacterium rectale ATCC 33656
           RepID=C4ZFT9_EUBR3
          Length = 338

 Score =  186 bits (472), Expect = 8e-46,   Method: Compositional matrix adjust.
 Identities = 113/308 (36%), Positives = 161/308 (52%), Gaps = 39/308 (12%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67
           I TR S LAL Q  YV DKL  ++P    + V + T GD+     L K+G KG+FVKE+E
Sbjct: 5   IGTRGSKLALVQTDYVIDKLKRAYPDDDFKAVIIKTTGDLEQKKALDKIGSKGIFVKEIE 64

Query: 68  VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127
             LL  +  +AVHSMKD+P E   GL      +REDPRD  V  N  SLD LP G+++GT
Sbjct: 65  DELLSGKIHMAVHSMKDMPDEPAAGLTFAKAWKREDPRDVLVLKNAASLDELPHGAVIGT 124

Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE------------------------ 163
            S RR+ QL + RPDL +  +RGN+ TRL KL +GE                        
Sbjct: 125 GSKRRKYQLLKLRPDLKVVGIRGNIDTRLRKLYDGEIIYEEVADNTVNNNEIANEKKNKY 184

Query: 164 ----YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAAL 219
                D I+LA AG+KR+G +S I      +  +PA  QG + +E R D+++    L AL
Sbjct: 185 SEYRLDGIVLAAAGIKRIGRDSEITQYFSEDDMIPAPAQGTLALELRADNAKLMAKLDAL 244

Query: 220 NHHETALRVTAERAMNTRLEGGCQVPIGSYAELI-----------DGEIWLRALVGAPDG 268
           +  +T L    ER    ++ G C +P+ +Y +++           +  + L A+ G+ DG
Sbjct: 245 SDEKTNLCAGIEREFLKQIGGNCHLPVAAYCDIVSEKDRGNDSNKNNRLKLLAMFGSEDG 304

Query: 269 SQIIRGER 276
            Q+ R E+
Sbjct: 305 KQLARTEQ 312


>UniRef50_Q0ATQ1 Porphobilinogen deaminase n=3 Tax=Alphaproteobacteria
           RepID=Q0ATQ1_MARMM
          Length = 321

 Score =  186 bits (471), Expect = 1e-45,   Method: Compositional matrix adjust.
 Identities = 132/298 (44%), Positives = 168/298 (56%), Gaps = 16/298 (5%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVE-------LVPMVTRGDVILDTPLAKVGG 58
           L IATR+SPLAL QA  V+ KL A+  GL  E       ++ +V+ GD I D  L + GG
Sbjct: 8   LAIATRRSPLALVQARDVQAKL-AAQCGLSGEDAERCFPILGLVSTGDRIQDRTLIEAGG 66

Query: 59  KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS-LD 117
           KGLF KE++ A L+ RA  AVHSMKDVP   P G+ L  + EREDPRD  ++ + ++ L 
Sbjct: 67  KGLFTKEIDEAQLDGRAAFAVHSMKDVPTVLPDGIVLGALLEREDPRDMLIARDGETRLA 126

Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177
            LP G  +GT+SLRRQ QL  +RPDL +  LRGNV TRL KL +G   A  LA AGL RL
Sbjct: 127 DLPEGVTIGTASLRRQAQLLHKRPDLHVVPLRGNVDTRLGKLADGGIHATFLARAGLNRL 186

Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237
           G    +R  L  +  LPA  QGAVG+  R  D      +A L+H +T L V AERA    
Sbjct: 187 GRAEALRDPLEADEMLPAAAQGAVGVAIRDGDEEAASYVAGLHHRDTELAVLAERAFLFE 246

Query: 238 LEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-----GAPQDAEQMGISL 290
           L+G C+ PI ++   +  +     L   PDG Q  R + R       P  A Q G  L
Sbjct: 247 LDGSCRTPIAAHVNKVSMDFIGEVLT--PDGQQSWRRQIRFDMTHATPDSARQAGQDL 302


>UniRef50_Q4PFH9 Putative uncharacterized protein n=1 Tax=Ustilago maydis
           RepID=Q4PFH9_USTMA
          Length = 770

 Score =  186 bits (471), Expect = 1e-45,   Method: Compositional matrix adjust.
 Identities = 117/292 (40%), Positives = 155/292 (53%), Gaps = 39/292 (13%)

Query: 38  LVPMVTRGDVILDTPLAKVGGKG--LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGL 95
           +  M T GD  L +PL  +GG+G  ++ KELEVAL +   D  VH +KDVP   PQGL L
Sbjct: 253 ITSMSTAGDQNLRSPLYVIGGEGKAIWTKELEVALEQGAVDAIVHCLKDVPTALPQGLEL 312

Query: 96  VTICEREDPRDAFVSNN---YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNV 152
             + EREDPRDA V      Y  LD LP GS++GTSS+RR  QL  R P L+   +RGN+
Sbjct: 313 AAVLEREDPRDALVVKAGLPYKVLDELPVGSVIGTSSVRRVAQLRRRYPHLVFSDVRGNI 372

Query: 153 GTRLSKLD--NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLD-- 208
            TRL+KLD  NG Y A+ILA AGL RL + +RI A L   + L +VGQG++ IE R    
Sbjct: 373 NTRLAKLDAPNGPYTALILAAAGLVRLNMHARITAFLSSPVLLHSVGQGSLAIEVRTPPE 432

Query: 209 --------DSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLR 260
                   D+R REL+ ++       R  AER++   LEGGC +P+G             
Sbjct: 433 GADPTTNRDARIRELIRSIGDWRATFRAEAERSLLKELEGGCSIPVGVETRF-------- 484

Query: 261 ALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYNGDAP 312
                 D    + G+R  A        I+L ++ +  G     AE+ NG  P
Sbjct: 485 ------DDHDQVEGQRSEA--------IALVDDFVTQGNAGAKAELPNGGMP 522


>UniRef50_C9M5W1 Hydroxymethylbilane synthase n=1 Tax=Jonquetella anthropi E3_33 E1
           RepID=C9M5W1_9BACT
          Length = 714

 Score =  186 bits (471), Expect = 1e-45,   Method: Compositional matrix adjust.
 Identities = 121/298 (40%), Positives = 165/298 (55%), Gaps = 9/298 (3%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           L   LR+A+R+S LA+ Q+  V ++L  +  G  VE++P  TRGD + D  L   GGKGL
Sbjct: 422 LGRPLRLASRESELAMAQSRLVAERLHEAT-GFDVEIIPFRTRGDAVADRRLESAGGKGL 480

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FVKELE A+L  +AD+AVHS+KD+P   P GL    + +R+   D  V      L   P 
Sbjct: 481 FVKELERAILSGQADLAVHSLKDMPSSCPDGLAFAALMDRQTAFDCLVLR--PGLTGRPV 538

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
              +GTSS RR  Q      D     LRGN+ TRLSKLD GE+DA+ILA AGL+RLGL+ 
Sbjct: 539 --RIGTSSARRIAQGRALFSDAQFVPLRGNLRTRLSKLDGGEFDALILAEAGLRRLGLQE 596

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
           R+      +  +P+ GQG + ++C  D     +L++ L+         AERA   RL GG
Sbjct: 597 RVSRVFSADQMIPSAGQGTLAVQCPFDGP-VFDLVSQLDEPAVRTCCLAERAFIDRLNGG 655

Query: 242 CQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
           C  P G+YA  +DGE I +  L   PDG + + G+  G   D   +   LA+ L   G
Sbjct: 656 CTAPHGAYAR-VDGETIEMIGLYVRPDG-KTLSGKISGPAADGPSLAAELADRLKRRG 711


>UniRef50_C5EV71 Pyruvate ferredoxin/flavodoxin oxidoreductase n=3 Tax=Clostridiales
           RepID=C5EV71_9FIRM
          Length = 301

 Score =  185 bits (470), Expect = 2e-45,   Method: Compositional matrix adjust.
 Identities = 116/269 (43%), Positives = 153/269 (56%), Gaps = 15/269 (5%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           + N++RI TR+S LAL Q H + D L  + P + VELV   T GD ILD PL + GGKG+
Sbjct: 1   MSNIIRIGTRKSALALIQTHLIADGLKRAWPDIEVELVTKETLGDKILDKPLQEFGGKGV 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FV E E A+ E   D+AVHS KD+P+E  +GL +  +  R DPRD  V+      D    
Sbjct: 61  FVSEFEQAMKEGAIDLAVHSAKDLPMELGEGLVIAAVSGRGDPRDVLVTMKGSPKDR--E 118

Query: 122 GSIVGTSSLRRQCQLAERR-------PDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174
             ++GTSS RRQ +  E R         L   +LRGNV TRL KL+ G YD IILA AGL
Sbjct: 119 HIVIGTSSPRRQLEAVEYRGQLWPGAASLTCATLRGNVHTRLRKLEEGLYDGIILAAAGL 178

Query: 175 KRLGL---ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231
           +RL L    S     L P + +PA GQG + +E R + S    L  A++  E  L +T E
Sbjct: 179 ERLDLLGNPSYDFKYLDPTVFIPAGGQGIMAVEAR-EGSDAARLCQAIDSREGRLCLTLE 237

Query: 232 RAMNTRLEGGCQVPIGSYAELIDG--EIW 258
           R +   L+ GC  PIG Y+ ++DG  E+W
Sbjct: 238 RMVLKLLDAGCHEPIGIYSNIMDGKMEVW 266


>UniRef50_Q93A65 Porphobilinogen deaminase n=1 Tax=uncultured bacterium
           RepID=Q93A65_9BACT
          Length = 299

 Score =  185 bits (470), Expect = 2e-45,   Method: Compositional matrix adjust.
 Identities = 116/254 (45%), Positives = 156/254 (61%), Gaps = 13/254 (5%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +R+ATR S LALWQA +V  +L+    G  VELV + T+GD     P A++ G+G F K 
Sbjct: 4   VRLATRGSRLALWQAEWVAKQLV--QQGAEVELVVVETQGDRE-KRPFAQMQGQGFFTKA 60

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD----ALP- 120
           ++ A+LE RAD AVHS KD+P   P GL +  +  REDPR+  +     ++D     LP 
Sbjct: 61  VQEAVLEGRADFAVHSYKDLPSARPAGLEIAAVPPREDPRELLLVR-LQAVDQVAPGLPL 119

Query: 121 -AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179
            AG+ VG+S+ RRQ QLA  RPDL +  LRGNV TR+ KL  GEYDA++LA AG++RLGL
Sbjct: 120 RAGARVGSSAARRQAQLAHLRPDLSLLELRGNVLTRVEKLRQGEYDAVLLAYAGVRRLGL 179

Query: 180 E--SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237
           +        LPP + +PA  QGA+ +ECR DD R R LL  L+     +R      M  R
Sbjct: 180 DLSPFHWQVLPPTLLVPAPAQGALALECRQDDKRLRPLLEPLDDPSAGVRCGGAGLM-AR 238

Query: 238 LEGGCQVPIGSYAE 251
           L GGCQ+ +G+ A+
Sbjct: 239 LAGGCQLALGALAQ 252


>UniRef50_A8PWJ5 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS
           7966 RepID=A8PWJ5_MALGO
          Length = 530

 Score =  185 bits (469), Expect = 2e-45,   Method: Compositional matrix adjust.
 Identities = 122/322 (37%), Positives = 171/322 (53%), Gaps = 56/322 (17%)

Query: 41  MVTRGDVILDTPLAKVGGKG--LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTI 98
           M T GD  L +PL  +GG+G  ++ KELEVAL+    D  VHS+KDVP   P G+ L  I
Sbjct: 161 MATLGDQNLKSPLYVIGGEGRAIWTKELEVALMAGGVDAIVHSLKDVPTTMPDGVELAAI 220

Query: 99  CEREDPRDAFVSNN---YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTR 155
            EREDPRDA V      Y SL  +P GS++GTSS+RR   L    P L+   +RGN+ TR
Sbjct: 221 LEREDPRDALVVKENLPYKSLQEMPQGSVIGTSSVRRVSLLRRAYPHLMFSDVRGNINTR 280

Query: 156 LSKLD--NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLD----- 208
           L+KLD  +G Y A++LA AGLKR+ LE RI A +   + L AVGQG++ IE R       
Sbjct: 281 LAKLDAADGPYTALVLAAAGLKRMDLEHRITAYVSEPVMLHAVGQGSLAIEVRTPRGESA 340

Query: 209 --DSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGE---------- 256
             D R R ++ ++++     R  AERA+  R+EGGC +P+G      D            
Sbjct: 341 ERDERIRRMIRSISNWRATWRCVAERALMHRMEGGCSIPLGVSTRFEDHADIEGLLNERN 400

Query: 257 ----------------------------IWLRALVGAPDGSQIIRGERRG---APQDAEQ 285
                                       + + A++ + DG+++ +        + +DAEQ
Sbjct: 401 ETPSEMASAGISRPDIRIAHEPPPQGSFLTMAAVIVSLDGTRMCKHSHTQLCRSEKDAEQ 460

Query: 286 MGISLAEELLNN-GAREILAEV 306
           +GI +AEEL ++  AR ILAEV
Sbjct: 461 LGILVAEELEHHQNARAILAEV 482


>UniRef50_Q6L2G8 Probable porphobilinogen deaminase n=1 Tax=Picrophilus torridus
           RepID=HEM3_PICTO
          Length = 282

 Score =  185 bits (469), Expect = 2e-45,   Method: Compositional matrix adjust.
 Identities = 105/255 (41%), Positives = 151/255 (59%), Gaps = 8/255 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR S LA+ QA  VKD+L     G+  E+    ++GD+ LD+PL  +GG G+FV +
Sbjct: 3   IRIGTRSSKLAMIQAMMVKDRL--DSLGIETEVKGFTSKGDINLDSPLYSIGGTGVFVDD 60

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L   +L+N  DIAVHS KD+P      L +  + +R+DPRD  +S +  SL+ L A S++
Sbjct: 61  LNRMILKNEIDIAVHSAKDIPSFIDDSLEISAVLKRDDPRDVLISQH--SLNDLEASSVI 118

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSSLRR  +L   R D++I+ LRGN+ TRL KLDNG+YD II+A A   R+ +  R   
Sbjct: 119 GTSSLRRIKELKTLRNDILIKDLRGNIDTRLKKLDNGDYDGIIMAKAAYDRMRINRR-HF 177

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L  +  +PA  QG + I  +  DS   ++L  +N  ET   + AER + + L  GC  P
Sbjct: 178 ILNYDDFVPAPNQGIIAIISK-KDSEINDVLKKINDDETYNDMKAERLILSGLNLGCSKP 236

Query: 246 IGSYAELIDGEIWLR 260
           +G YA      I++R
Sbjct: 237 VGIYAH--KNRIFMR 249


>UniRef50_A2BFN7 Hydroxymethylbilane synthase (Fragment) n=6 Tax=Coelomata
           RepID=A2BFN7_DANRE
          Length = 247

 Score =  185 bits (469), Expect = 2e-45,   Method: Compositional matrix adjust.
 Identities = 113/227 (49%), Positives = 144/227 (63%), Gaps = 4/227 (1%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           V+R+ TR+S LA  Q   V   L   +P + +E+V M T GD ILDT L+K+G K LF K
Sbjct: 21  VIRMGTRKSQLARIQTDSVAGTLKQLYPDVHLEIVAMSTIGDKILDTALSKIGEKSLFTK 80

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDSLDALPA 121
           ELE AL  N  DI VHS+KD+P   P G  +  I ERE+P DA V    N   +LD+LP 
Sbjct: 81  ELENALERNEVDIVVHSLKDLPTSLPPGFTIGAILERENPHDAVVLHPKNAGLTLDSLPE 140

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD-NGEYDAIILAVAGLKRLGLE 180
            S++GTSSLRR  QL +R P L   ++RGN+ TRL KLD   +Y AIILA AGLKR+G E
Sbjct: 141 KSVIGTSSLRRAAQLKKRFPQLEFENIRGNLNTRLKKLDEKDDYAAIILAAAGLKRMGWE 200

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALR 227
           SRI   L PE  + AVGQGA+ +E R  D    E+++ L+H +T LR
Sbjct: 201 SRISQVLGPEDCMYAVGQGALAVEVRAQDKDILEMVSVLHHPDTVLR 247


>UniRef50_O29026 Probable porphobilinogen deaminase n=1 Tax=Archaeoglobus fulgidus
           RepID=HEM3_ARCFU
          Length = 289

 Score =  184 bits (467), Expect = 3e-45,   Method: Compositional matrix adjust.
 Identities = 106/247 (42%), Positives = 148/247 (59%), Gaps = 7/247 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L + TR S LAL Q + V ++L   +    VE+  + T GD++ D PL +  G G FV+ 
Sbjct: 3   LIVGTRGSKLALAQTNKVAERLKERYE---VEIRIVKTAGDIMKDKPLYEFKGMGAFVRA 59

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L+ AL E + D+AVHS KDVP +  +G  +  + ER+ P D  +S +  +L+ L  G++V
Sbjct: 60  LDTALAEGKVDVAVHSFKDVPSQRVEGTVVAAVIERDSPCDVLISRDGSTLEELDEGAVV 119

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSSLRR+ QL+  R DL   +LRGN+ TRL KL  G YDAI++A AGLKRLGL+  +  
Sbjct: 120 GTSSLRRRAQLSRLRGDLRFENLRGNLDTRLRKLREGNYDAIVVAEAGLKRLGLDREVEY 179

Query: 186 A-LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
              PPE+ +P   QG + I  R  +    +L+A LN  +T L    ERA+   L  GC V
Sbjct: 180 QPFPPEVIVPPANQGIIAIATRKGEE---DLVAFLNDEKTWLEAMVERAVIKELGVGCAV 236

Query: 245 PIGSYAE 251
           P+G YAE
Sbjct: 237 PVGVYAE 243


>UniRef50_B2W5W6 Porphobilinogen deaminase n=2 Tax=Pleosporineae RepID=B2W5W6_PYRTR
          Length = 399

 Score =  184 bits (467), Expect = 4e-45,   Method: Compositional matrix adjust.
 Identities = 131/347 (37%), Positives = 182/347 (52%), Gaps = 47/347 (13%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG----GKGL 61
           + I TR S LA  QA  V+  L  ++P     + P++ +GD    TPL ++      K L
Sbjct: 31  VNIGTRNSVLAQIQARAVERSLKDAYPERTYNICPVIVQGDRDKITPLQQLSQGENAKSL 90

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN----NYDSLD 117
           +  ELE  L     DI VH +KD+P + P  L L  I EREDPRDA + +       +L 
Sbjct: 91  WTGELESMLESGDLDIIVHCLKDMPTQLPDHLELGAILEREDPRDALLVSPRLPKETTLA 150

Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLK 175
            LP G+ +GTSS+RR   L +  P L    LRGNVGTRL+KLD  +  Y AIILA AGLK
Sbjct: 151 TLPQGATIGTSSVRRAATLRKLYPHLKFADLRGNVGTRLAKLDAEDSPYSAIILAAAGLK 210

Query: 176 RLGLESRIRAALPPEIS--LPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERA 233
           R+GL++RI   L       L AVGQGA+GIE R +D   +EL++ +    T    +AERA
Sbjct: 211 RMGLDNRITQYLSSTSGGMLHAVGQGALGIEIRKNDEAMKELMSKIRCERTTRACSAERA 270

Query: 234 MNTRLEGGCQVPIG------------------------------SYAELIDGEIWLRALV 263
           +   LEGGC VPIG                                 ++ D E+ +RA+V
Sbjct: 271 LLRTLEGGCSVPIGVETSWKGGKGLSVGPQPAKDYDKHGNAVEEDEPDVDDQELVMRAMV 330

Query: 264 GAPDGSQIIRGER----RGAPQDAEQMGISLAEELLNNGAREILAEV 306
            + DG + +  E     R A ++AE+MG  +A+ L+  GA +IL ++
Sbjct: 331 VSVDGKESVEYEATRKVRNA-EEAEEMGREVAKILIEKGADKILEKI 376


>UniRef50_A9HK97 Porphobilinogen deaminase n=12 Tax=Acetobacteraceae
           RepID=A9HK97_GLUDA
          Length = 367

 Score =  183 bits (464), Expect = 8e-45,   Method: Compositional matrix adjust.
 Identities = 134/320 (41%), Positives = 173/320 (54%), Gaps = 21/320 (6%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGL----VVELVPMVTRGDVILDTPLAKVGGKGL 61
           LR+ TR SPLAL Q       L    P L      +   + T GD + +  LA++GGKGL
Sbjct: 47  LRVGTRASPLALVQTRAFLTMLTRFCPVLRDMGAFQEHQINTTGDQVQNRRLAEIGGKGL 106

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV-----------S 110
           F KE+  AL + R D AVHS+KD+    P GL L     RED RDA +           +
Sbjct: 107 FAKEIHDALSDGRIDFAVHSLKDLETTLPPGLVLACTLRREDARDALILGPGAGGRHDAA 166

Query: 111 NNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILA 170
           +  D   ALP  ++VG +S+RRQ Q+   RPDL    LRGNV TRL KL   + DA +LA
Sbjct: 167 DAADPYAALPRNALVGCASVRRQAQMLHVRPDLRFGLLRGNVQTRLDKLAARQCDATLLA 226

Query: 171 VAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTA 230
           +AGL+RLG+E R    L PEI +PA GQG VG+  R  D   RELLAA+  +E     TA
Sbjct: 227 LAGLRRLGMEDRADIVLDPEIMVPAAGQGIVGVTVRESDVELRELLAAIEDYEARAVATA 286

Query: 231 ERAMNTRLEGGCQVPIGSYAELIDG------EIWLRALVGAPDGSQIIRGERRGAPQDAE 284
           ERA+   L+G C+ PIG YA L+ G       + L  LV   DGS ++R    G   DAE
Sbjct: 287 ERALLAELDGSCRTPIGGYARLVPGLAGAEASLRLTGLVAREDGSFLLRRTVTGLRADAE 346

Query: 285 QMGISLAEELLNNGAREILA 304
           +MG  L   L  +   ++ A
Sbjct: 347 EMGRELGRSLRMDSPSDVFA 366


>UniRef50_C1XV35 Porphobilinogen deaminase n=2 Tax=Meiothermus RepID=C1XV35_9DEIN
          Length = 304

 Score =  182 bits (461), Expect = 2e-44,   Method: Compositional matrix adjust.
 Identities = 118/266 (44%), Positives = 165/266 (62%), Gaps = 10/266 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RIATR S LA WQA +V  +L     G+   LV + T+GD       +++ G+G F K 
Sbjct: 4   VRIATRGSRLARWQAEWVAAQL--QDQGIASTLVIVETQGDRE-RVAFSQMQGQGFFTKA 60

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV--SNNYDS-LDALP-- 120
           ++ A+ E RAD+AVHS+KD+P     GL L  I  REDPR+A +   + +D+   ALP  
Sbjct: 61  VQDAVREGRADLAVHSLKDLPSAPTPGLVLAAIPIREDPREALLVLPSAWDAQAPALPLA 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ VG+S++RRQ QLA+ RPDL +  LRGNV TR+ KL +G Y+AI+LA AGLKRLGL+
Sbjct: 121 PGARVGSSAVRRQAQLAQLRPDLKLLELRGNVPTRVEKLQSGGYEAILLAWAGLKRLGLD 180

Query: 181 SRIRAA--LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
               A   L P   +PA GQGA+ +ECR +D++ R +L  L+     L V  ER +  RL
Sbjct: 181 LGGLAVRLLEPREFVPAPGQGALALECREEDTQLRGVLQGLDDPTARLTVGIERGLMARL 240

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVG 264
           +GGCQ+ +G+ A+ + G   L A  G
Sbjct: 241 QGGCQLALGASAQRVQGGWQLLAWYG 266


>UniRef50_A4QB59 Porphobilinogen deaminase n=15 Tax=Corynebacterium RepID=HEM3_CORGB
          Length = 302

 Score =  181 bits (459), Expect = 3e-44,   Method: Compositional matrix adjust.
 Identities = 120/305 (39%), Positives = 173/305 (56%), Gaps = 10/305 (3%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            L+I TR S LA  QA  ++D+L   + G   EL  + T GDV + +P+ ++G  G+F +
Sbjct: 2   TLKIGTRGSKLATTQAGTIRDQL--KYFGRDAELHIVTTPGDVNM-SPVERIG-VGVFTQ 57

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
            L   L     D+AVHSMKD+P        LV +  R D R+A ++ +  +L  LP G+ 
Sbjct: 58  ALRDVLHAGECDVAVHSMKDLPTAADPRFHLV-VPTRADSREALIARDGLTLAELPEGAK 116

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGTS+ RR  QL   RPDL I  LRGN+ TR+ K+ +GE DA++LA AGL R+G++ R  
Sbjct: 117 VGTSAPRRISQLKAIRPDLEILPLRGNIDTRMGKVTSGELDAVMLAYAGLTRVGMQDRAT 176

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
                +I +PA  QGA+ IECR DD+ T   L  L H +T +   AER +  RLE GC  
Sbjct: 177 EVFDADIIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVLNRLEAGCTA 236

Query: 245 PIGSYAELIDG----EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           P+ ++A L DG     + L A V A DGS  +     G     E++G  +A++L++ GA 
Sbjct: 237 PVAAHATL-DGYSGDTMTLTAGVYALDGSDQLVFSAEGDGARPEELGELVAQQLIDAGAA 295

Query: 301 EILAE 305
            +L +
Sbjct: 296 NLLGD 300


>UniRef50_C6V4N6 Porphobilinogen deaminase n=2 Tax=Neorickettsia RepID=C6V4N6_NEORI
          Length = 286

 Score =  181 bits (458), Expect = 4e-44,   Method: Compositional matrix adjust.
 Identities = 113/290 (38%), Positives = 164/290 (56%), Gaps = 9/290 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L++  R S LAL QA  V+  L        ++LV + T GD++ D PL +VGGK LF+KE
Sbjct: 4   LKVGARCSTLALAQARLVERALAPYCER--IDLVGVRTSGDILSDIPLTEVGGKALFLKE 61

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           LE  LL    DIAVHSMKDVP  +   L +V + +R  P D FVS  Y ++ +LP+G+++
Sbjct: 62  LEEKLLTGEIDIAVHSMKDVPAFYHDDLEVVPVLKRAIPNDVFVSFRYPNMLSLPSGAVI 121

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GT + RR  QL +R     +  LRGN+ TR+ K  N   D IILA  GL+RLGL   I  
Sbjct: 122 GTCAPRRVVQLNQR---FRVIPLRGNIATRVEKAKN--LDGIILAFCGLERLGLCKMISE 176

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            +  ++ LP V QGA+ +E R  D   REL+  ++  ET +  TAERA    + G C+  
Sbjct: 177 VIHEDVMLPGVAQGALCVEFRKKDHFLRELILNISDRETIICTTAERAFLEEINGDCKTA 236

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295
           +G+ A + +  ++   ++G  +     R    G+  +A+Q+G S A  LL
Sbjct: 237 LGALAVVKNNTLYFTGMLGKDNRPCYFRTS--GSCLNAKQIGRSAALALL 284


>UniRef50_A8SQW4 Putative uncharacterized protein n=1 Tax=Coprococcus eutactus ATCC
           27759 RepID=A8SQW4_9FIRM
          Length = 350

 Score =  180 bits (456), Expect = 6e-44,   Method: Compositional matrix adjust.
 Identities = 109/265 (41%), Positives = 150/265 (56%), Gaps = 20/265 (7%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            +++ TR S LAL Q   V   L    P +  ++V M TRGD      L + GGK +FV+
Sbjct: 41  TVKVGTRGSKLALAQTELVIKALNERFPQIDFQMVTMSTRGDRDTSRALLEFGGKAVFVE 100

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           E E A+L+   DIAVHS KD+P+E  +GL +     R  P+D F+  +  S D   +  +
Sbjct: 101 EFEEAILKGDIDIAVHSAKDMPMEIMEGLTISGTLPRACPQDVFIYKSGRSFDRNDS-FV 159

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL----- 179
           VGTSSLRRQ Q+ +  P+ + ++LRGNVGTR+ KL++GEYDAIILA AGL+RLG+     
Sbjct: 160 VGTSSLRRQYQIRDMYPNAVCKNLRGNVGTRIQKLEDGEYDAIILAAAGLERLGVIEDKG 219

Query: 180 ------------ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALR 227
                       E   R  L  E  LPA  QG + IE R       +++ A+N  E   +
Sbjct: 220 NDSTECFEVHKDELTFR-YLSTESMLPAACQGIIAIETRT-SGEAYDMVRAINDTEAYTQ 277

Query: 228 VTAERAMNTRLEGGCQVPIGSYAEL 252
           +T ERA+ +RL  GC  PIG Y+EL
Sbjct: 278 LTCERAVLSRLNAGCHEPIGVYSEL 302


>UniRef50_C7M2H5 Porphobilinogen deaminase n=1 Tax=Acidimicrobium ferrooxidans DSM
           10331 RepID=C7M2H5_ACIFD
          Length = 291

 Score =  179 bits (455), Expect = 8e-44,   Method: Compositional matrix adjust.
 Identities = 123/294 (41%), Positives = 169/294 (57%), Gaps = 14/294 (4%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RIATR+S LA WQA  V ++L         ELV + T GD    + LA++GG+G+FVKE
Sbjct: 4   VRIATRRSALARWQASLVGERLGR------YELVEVHTAGDRDQASSLAEIGGQGVFVKE 57

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           ++ A++   ADIAVHS KD+P      L L  + ER D RDA V      L+ L  G+ V
Sbjct: 58  VQAAVVRGEADIAVHSAKDLPTAAGPLL-LAAVLERADARDAIVGAR---LEELAIGARV 113

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTS+ RR  QL   RPDL + S+RGN+ TRL ++  GE DAI++AVA L+RLGLE     
Sbjct: 114 GTSAPRRAAQLRLLRPDLEVVSIRGNIATRLGRV--GELDAIVMAVAALERLGLEEPPWW 171

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            LP E+  P  GQGA+ +EC  D     E L +L+   +   + AERA+      GC +P
Sbjct: 172 PLPEEVLCPQAGQGAIAVECAPDADGLIERLRSLDDDRSRREIEAERAVLAAFGTGCALP 231

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
           +G+ A      + LRA+   PDG++ +  ER G   D   +G ++AE L   GA
Sbjct: 232 LGARAHADGSSLRLRAVAVDPDGTRQLEVEREGV--DPATLGATVAEVLRRLGA 283


>UniRef50_B3DZQ6 Porphobilinogen deaminase n=1 Tax=Methylacidiphilum infernorum V4
           RepID=B3DZQ6_METI4
          Length = 298

 Score =  179 bits (454), Expect = 1e-43,   Method: Compositional matrix adjust.
 Identities = 115/294 (39%), Positives = 166/294 (56%), Gaps = 3/294 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L I +R S LAL QA  + D L   +P L +++  + T GD +   P+  +  +G+F KE
Sbjct: 4   LIIGSRGSRLALIQAQLIVDSLKKEYPLLDIQIRVIKTTGDHLEAQPIRDIDQRGIFTKE 63

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E  LLE   D+AVHS+KD+ VE    L +  I  REDPRD ++S  +    +L AG+IV
Sbjct: 64  IENKLLEGEIDLAVHSLKDLQVELHPRLVIAAIPPREDPRDCWISLQHPHPSSLQAGAIV 123

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-DNGEYDAIILAVAGLKRLGLE--SR 182
            T S RR  QL  +RPDL I  +RGNV +RL KL +N ++   +LA+AG+KRLG++  S 
Sbjct: 124 VTGSPRRANQLLRKRPDLRIVPVRGNVESRLRKLRENRQWQGTVLALAGIKRLGIDISSF 183

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
               L  +  LPA GQGA+ ++ R++D  T+ L+  LN   TA  VTAER     L GGC
Sbjct: 184 FCTPLSMDWMLPAPGQGALALQARIEDKHTQSLVKHLNDFSTACAVTAERVFLHELGGGC 243

Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
           +  +G+ AE+    + L  +       +   G+  G    AE +G  LA+ L N
Sbjct: 244 RTAVGARAEVEGSRLVLEGIWWPQQAIEPKEGKVVGEIHRAEDLGKKLADLLKN 297


>UniRef50_C5CB88 Porphobilinogen deaminase n=5 Tax=Actinomycetales RepID=HEM3_MICLC
          Length = 377

 Score =  179 bits (454), Expect = 1e-43,   Method: Compositional matrix adjust.
 Identities = 122/304 (40%), Positives = 165/304 (54%), Gaps = 38/304 (12%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LRI TR S LA  Q  +V + L A   GL  ELV + T GDV   + LA +GG G+F   
Sbjct: 4   LRIGTRGSALATTQTSHVAEALTARS-GLAHELVVIRTEGDVTTGS-LASLGGTGVFASA 61

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L  A+L+   D AVHS+KD+P   P+ L +  +  R D RDA  + +  +L  LP G+ V
Sbjct: 62  LRAAVLDGVVDAAVHSLKDLPAAQPETLEIAAVPARADLRDALCARDGLTLATLPEGARV 121

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN----------------GEYDAIIL 169
           GT S RR  QL   RPDL +  +RGNV TRL+++                  G+ DA+IL
Sbjct: 122 GTGSPRRVAQLKALRPDLELVDIRGNVQTRLARVPGLEQHDDHAPAAVGSPRGDLDAVIL 181

Query: 170 AVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDD---------------SRTRE 214
           A AGL RLGL+  I   + PE+ +PA GQGA+ +E R +D                R   
Sbjct: 182 ACAGLDRLGLDHVITERIDPEVMVPAPGQGALAMEIRAEDESFLGRALLDPEAPVGRLHA 241

Query: 215 LLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGE-----IWLRALVGAPDGS 269
            L  ++  +T + VTAERA+  RLE GC  PIG+ A + DGE     I + A+V A DGS
Sbjct: 242 ALELVDDRDTHVAVTAERALLRRLEAGCAAPIGAVARVGDGEAGAPRIEMTAMVAALDGS 301

Query: 270 QIIR 273
           +++R
Sbjct: 302 RVLR 305


>UniRef50_C7DH16 Porphobilinogen deaminase n=1 Tax=Candidatus Micrarchaeum
           acidiphilum ARMAN-2 RepID=C7DH16_9EURY
          Length = 301

 Score =  179 bits (454), Expect = 1e-43,   Method: Compositional matrix adjust.
 Identities = 107/300 (35%), Positives = 172/300 (57%), Gaps = 7/300 (2%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M ++ + I TR S LA+ QA  V++KL A  P +   +V + T  + + D   A+   K 
Sbjct: 1   MSESEITIGTRGSELAVAQAEIVRNKLAAIEPRISFRIVKIKTLNEKV-DRSKARTE-KD 58

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           ++ KE++ A+LE R DIAVHS+KD+     + + +  + +R+DPRD F+ N     + L 
Sbjct: 59  IYTKEIDEAILERRIDIAVHSLKDLKFNMDENMQIGAVPDRDDPRDVFIGNTETEFEHLG 118

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
             ++VGTSS+RR+ QL    P  +I  L GN+ TRLSKL++GE+  I++A AG+KRLG  
Sbjct: 119 TDALVGTSSIRRRVQLTRINPKPMISDLHGNIDTRLSKLNSGEFSGIVIAAAGVKRLGKA 178

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            R++     ++ +PA+GQGA+ +    D+S   ELL  +++ +  + V  E         
Sbjct: 179 VRMQYFDERDV-VPAIGQGAIAVTVHKDNSAAAELLKRIDNMKARVEVGEEIEFGKAFGT 237

Query: 241 GCQVPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
           GC +PIG+ A++++ G+I +   V    G  +++GE    P  A   G SLAE L+  GA
Sbjct: 238 GCNLPIGANAKMLESGKIGIVGFVSDLAGKTLVKGETETGPGHA---GKSLAELLIKKGA 294


>UniRef50_D2RH82 Porphobilinogen deaminase n=2 Tax=Archaeoglobaceae
           RepID=D2RH82_ARCPR
          Length = 292

 Score =  179 bits (453), Expect = 1e-43,   Method: Compositional matrix adjust.
 Identities = 100/244 (40%), Positives = 145/244 (59%), Gaps = 6/244 (2%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67
           + TR S LAL Q   V ++L     G  VE+  + + GD++ D PL +  G G FV+ LE
Sbjct: 7   VGTRGSKLALAQTSKVVERL--KEEGYSVEIRIIKSTGDIMKDKPLYEFKGSGAFVRALE 64

Query: 68  VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127
            AL+    D+AVHS KD+P    +G+ +  + ER+ P DAF++ N +SL+ +   +++GT
Sbjct: 65  HALVRGEIDVAVHSYKDIPSNMLEGVTVSAVLERDSPYDAFIARNGESLEEIKPNAVIGT 124

Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAAL 187
           SSLRR+ QL   R DL   +LRGNV TRL KL  G YDAI+LA AG++RLGL  + +  L
Sbjct: 125 SSLRRRAQLKLYRSDLRFENLRGNVDTRLRKLREGLYDAIVLAEAGIQRLGLNVKYQ-RL 183

Query: 188 PPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIG 247
           P E  +P   QG + ++ R+ +    +L+  +NH ET +    ER +   L  GC +P G
Sbjct: 184 PIERFVPPANQGIIAVQTRVGEE---DLVKFMNHEETWIEAEVERIVMKTLGVGCAIPAG 240

Query: 248 SYAE 251
            YAE
Sbjct: 241 IYAE 244


>UniRef50_B4D5X7 Porphobilinogen deaminase n=1 Tax=Chthoniobacter flavus Ellin428
           RepID=B4D5X7_9BACT
          Length = 307

 Score =  179 bits (453), Expect = 2e-43,   Method: Compositional matrix adjust.
 Identities = 114/276 (41%), Positives = 153/276 (55%), Gaps = 15/276 (5%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKV---GGKGLFVK 64
           + TR S LA+ Q       L A+ P + +E    VTRGD  LD  L +    GGKGLF K
Sbjct: 6   LGTRASALAVAQVELTTKALAAAFPAMQIERREFVTRGDKKLDLSLLRANEAGGKGLFTK 65

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           ELE ALL    D+AVHS+KD+P   P GL +  + ER    D  ++    +L  LP G +
Sbjct: 66  ELEDALLNGSIDVAVHSLKDLPGHNPPGLDITAVLERAPTADVLITKQPQTLLDLPQGVL 125

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-DNGEYDAIILAVAGLKRLG----- 178
           +GTSS+RR  QL  RRPD+ +   RGNV TRL KL +  +   IILA AGL+RLG     
Sbjct: 126 LGTSSVRRARQLQWRRPDVRVEEWRGNVQTRLRKLAERDDVTGIILAQAGLERLGHDLSA 185

Query: 179 --LES---RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERA 233
             LE+   +       E  LPA+GQGA+ ++ R D +    +L  ++H ET L + AER 
Sbjct: 186 GRLETEHGKFYVTSLAEDLLPAIGQGAIALQSRADRAEVAAVLQKIDHRETHLAIRAERE 245

Query: 234 MNTRLEGGCQVPIGSYAELIDGEIWLRA-LVGAPDG 268
           +   L G C +P+G   +L+ G I +RA L G PD 
Sbjct: 246 LQRLLAGDCALPVGVRTKLLPGGIAMRAILFGPPDA 281


>UniRef50_UPI000174444E Hydroxymethylbilane synthase n=1 Tax=Verrucomicrobium spinosum DSM
           4136 RepID=UPI000174444E
          Length = 318

 Score =  176 bits (446), Expect = 1e-42,   Method: Compositional matrix adjust.
 Identities = 117/278 (42%), Positives = 152/278 (54%), Gaps = 16/278 (5%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG---- 57
             + LR+ TR S LAL QA  V+  L A+HP L VE   + T GD   D   ++      
Sbjct: 5   FTDTLRLGTRGSELALRQAEMVEAALHAAHPYLRVERKVIATTGDKRPDLRFSEFTEGDR 64

Query: 58  -GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSL 116
             KG+F KELE+AL     DIAVHS+KDVP    +   +  +  R    D  +S    +L
Sbjct: 65  LDKGIFTKELEIALASGEIDIAVHSLKDVPTVLDEKFFIAGVLPRAPIEDVLISREGYTL 124

Query: 117 DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-DNGEYDAIILAVAGLK 175
             LPAG+ VGTSS+RR  QL    P +    +RGNV TR+ KL    + DAI+LA AGL+
Sbjct: 125 ATLPAGAKVGTSSVRRIRQLQWLNPGVECVEIRGNVPTRIRKLFAPSDLDAILLARAGLE 184

Query: 176 RLGL----------ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETA 225
           RL L          +      L  E  LPA GQGA+GIE R+DD+ T E L A+NH ET 
Sbjct: 185 RLSLLDGEHVVVDGQPLHAVILDCEEFLPAAGQGAIGIEARVDDAHTLEFLKAINHEETY 244

Query: 226 LRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALV 263
            RVTAER     L+ GCQ PIG++  L +G + ++  V
Sbjct: 245 ARVTAEREFLHILKAGCQTPIGAHTFLENGVLQMKVRV 282


>UniRef50_Q1GP41 Porphobilinogen deaminase n=7 Tax=Sphingomonadales RepID=HEM3_SPHAL
          Length = 315

 Score =  176 bits (445), Expect = 1e-42,   Method: Compositional matrix adjust.
 Identities = 130/279 (46%), Positives = 165/279 (59%), Gaps = 7/279 (2%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLV--VELVPMVTRGDVILDTPLAKVGGKG 60
           DN LRI TR SPLA+ QAH     L+A+H   +  +E+VPM   GD I D  LA+VGGK 
Sbjct: 8   DNPLRIGTRASPLAMAQAHMAAAALIAAHGLAMAALEIVPMTATGDRIQDRALAEVGGKA 67

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLD 117
           L+ +EL+ AL     D+AVHS+KDV         L  + ER DPRD  V         + 
Sbjct: 68  LWTRELDAALDAGTIDVAVHSLKDVETLRDARFFLGAMLERADPRDRLVVREGIAAQKIS 127

Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177
            LP G+ +GTSS RR  Q+   RPDL    LRGNV TRL+KL  GE DA +LA AGL+RL
Sbjct: 128 ELPHGARLGTSSPRRAAQVRRLRPDLDTVLLRGNVATRLAKLAAGEADATLLAAAGLERL 187

Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237
           G+   I A    E+ LPA  QGA+GIECR DD+ T  LLAA++H  T   V AERA+   
Sbjct: 188 GMHD-IGAVQGTELLLPAASQGAIGIECRADDAATIALLAAIDHAPTHRAVAAERALLAV 246

Query: 238 LEGGCQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGE 275
           L G C+ P+ +YAE   DG + L A + + DG+  + G 
Sbjct: 247 LGGDCRSPVAAYAEWQADGVLRLDAEIFSEDGADHVAGH 285


>UniRef50_UPI0001BC2D4C glutamyl-tRNA reductase n=1 Tax=Brevibacterium linens BL2
           RepID=UPI0001BC2D4C
          Length = 825

 Score =  176 bits (445), Expect = 1e-42,   Method: Compositional matrix adjust.
 Identities = 109/277 (39%), Positives = 158/277 (57%), Gaps = 15/277 (5%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            +R+ TR+S LA  Q+  +  +L A+  G  VE+V +VT GDV + +PL   GG G+FV 
Sbjct: 478 TIRLGTRRSKLARSQSTAIAHQL-AALTGWRVEIVEVVTEGDVNM-SPLTGFGGTGVFVS 535

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
            +  AL + + DIAVHS+KD+P     G+ +  I  R DP D  +  +  S   LPAGS+
Sbjct: 536 AVRQALHQGKIDIAVHSLKDLPTTPEAGIQMAAIPPRVDPADVLIGRDGLSFAELPAGSV 595

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGT S RR  QL   RPD+ +R +RGNV TR++ + +G  DA++LA AG++R+G  +   
Sbjct: 596 VGTGSPRRAVQLRAARPDIEVRGVRGNVDTRIAHVRDGRLDAVVLAAAGVRRIGRLAEAT 655

Query: 185 AALPPEISLPAVGQGAVGIECR-------LD------DSRTRELLAALNHHETALRVTAE 231
            +L  +  LPA GQGA+ +E R       LD      D+  R  L  L+   T L VT E
Sbjct: 656 DSLDFDTMLPAPGQGALAVETRGADSPFALDNEVMEADAEVRTQLKRLHDETTDLAVTCE 715

Query: 232 RAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDG 268
           RA+ +R E GC  PIG+ A +   +  + A++   DG
Sbjct: 716 RAILSRAEAGCSAPIGALATIQGSDFVVDAVMADDDG 752


>UniRef50_A4XK06 Porphobilinogen deaminase n=2 Tax=Clostridia RepID=HEM3_CALS8
          Length = 290

 Score =  175 bits (444), Expect = 2e-42,   Method: Compositional matrix adjust.
 Identities = 106/291 (36%), Positives = 155/291 (53%), Gaps = 8/291 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LRI  R S L+  Q   V  K+  +  G+  E VP+ T+GD+     L      G+FVKE
Sbjct: 4   LRIGARDSKLSRIQVDIVARKIKQT-LGIECEFVPIKTKGDIDKTKSLKDFKSPGVFVKE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E+ALL    D+AVHS+KD+P E      +V + EREDPRD  VS +      L   + +
Sbjct: 63  IELALLSREIDLAVHSLKDLPCEMDSNFEIVAVVEREDPRDVLVSKDGVGFYQLKPNAKI 122

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSSLRR+  L   R D+ + ++RGN+ TRLSK+++   D ++LA A LKRL L+S +  
Sbjct: 123 GTSSLRREVHLKNLRQDIQVVNIRGNIETRLSKIESEGLDGVVLAYAALKRLNLDSHVSY 182

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
                   P  GQGA+ IEC L DS  + +L+ +N  +  ++   ER +   L GGC   
Sbjct: 183 IFDVNEITPCPGQGAICIEC-LKDSPYKNILSKINDADAYIQTQFERLVLKFLGGGCHSS 241

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
           IG + +    +I+  A      G ++I+    G   D     +SLA +L N
Sbjct: 242 IGVFCKTDQDKIY--AFASILSGDKLIKASIEGDKDDF----LSLANKLSN 286


>UniRef50_C6XKH7 Porphobilinogen deaminase n=1 Tax=Hirschia baltica ATCC 49814
           RepID=C6XKH7_HIRBI
          Length = 323

 Score =  175 bits (444), Expect = 2e-42,   Method: Compositional matrix adjust.
 Identities = 109/271 (40%), Positives = 147/271 (54%), Gaps = 7/271 (2%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLV-VELVPMVTRGDVILDTPLAKVGGKGLF 62
            +++I  R SPLA+ QA     +        V +E+    T GD +LD  L   GGKGLF
Sbjct: 19  QIVKIGARGSPLAVQQAEDFAARFKEIVGNTVEIEIHTFTTSGDQLLDKRLQDAGGKGLF 78

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122
            +EL++A L  R DI VHS+KDVP   P GL +     REDPRDA       ++  LP G
Sbjct: 79  TRELDIAQLSGRIDIVVHSLKDVPTVLPDGLQMGCYLPREDPRDALFGK-VGNIKDLPHG 137

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           + +GT+SLRR  Q    RPDL I   RGNV TRL KL+ G+ DA +LA AGL RLG+  +
Sbjct: 138 ATLGTASLRRSAQALALRPDLKIVMFRGNVQTRLRKLEEGQADATLLAAAGLNRLGMTDK 197

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAA---LNHHETALRVTAERAMNTRLE 239
               +P E  LPA GQG V     L ++    +  A   ++  E+ +   AERA   RL+
Sbjct: 198 AAGFMPKEEMLPACGQGIVCTT--LTNNAEDWIFKACLQIDVLESRIAAIAERAFLKRLD 255

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQ 270
           G C+ PI  +    +  + +R  V A DGS+
Sbjct: 256 GSCRTPIAGHLSFNETGVDMRGEVLADDGSK 286


>UniRef50_C7R376 Porphobilinogen deaminase n=1 Tax=Jonesia denitrificans DSM 20603
           RepID=C7R376_JONDD
          Length = 344

 Score =  174 bits (442), Expect = 3e-42,   Method: Compositional matrix adjust.
 Identities = 129/342 (37%), Positives = 174/342 (50%), Gaps = 47/342 (13%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LR+ TR S LA  Q+      L+A   G+ V+L  + T GDV+  + LA +GG G+FV  
Sbjct: 4   LRLGTRASALATAQSRATA-ALIAQATGVTVDLTHIRTDGDVLTGS-LATMGGAGVFVTA 61

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +  ALL    DIAVHS+KD+P    +G  ++ + ERE+P+DA  S + +SL  LP G++V
Sbjct: 62  IRQALLAGDIDIAVHSLKDLPTTPHEGTTII-VPERENPQDALCSRHGESLAHLPHGALV 120

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD---------NGEYDAIILAVAGLKR 176
           GT S RR  QL   RPDL I  +RGNV TRL+++            + DA++LA AGL+R
Sbjct: 121 GTGSPRRAAQLLVARPDLRIVDIRGNVDTRLARVGLSTADKPHIRNDLDAVVLAAAGLRR 180

Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAA----LNHHETALRVTAER 232
           LG    I   LPP   LPA GQGA+ IE R D +     + A    L+H  TA  V AER
Sbjct: 181 LGRAHVISELLPPTSMLPAPGQGALAIEVRHDMADHHPSILAGIRTLHHQPTAYAVAAER 240

Query: 233 AMNTRLEGGCQVPIGSYAEL-----------IDGEIWLRALVGAPDGSQIIRGERR--GA 279
           A+   LE GC  P+G+ A +           +D  +   A    P  +  I        A
Sbjct: 241 AVLRHLEAGCAAPVGALATMHNTTLTLTATALDPRLTPTAHTPTPSTTTDINAAPTPMTA 300

Query: 280 P------------------QDAEQMGISLAEELLNNGAREIL 303
           P                   DA + GI+LA  LL +GA E L
Sbjct: 301 PADARPPIRLTHTHTVTSENDATEAGITLATTLLTHGAAEFL 342


>UniRef50_D2RNT2 Porphobilinogen deaminase n=1 Tax=Acidaminococcus fermentans DSM
           20731 RepID=D2RNT2_ACIFE
          Length = 288

 Score =  174 bits (442), Expect = 3e-42,   Method: Compositional matrix adjust.
 Identities = 119/294 (40%), Positives = 165/294 (56%), Gaps = 16/294 (5%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67
           +ATR S LAL Q H V   L     G+  E+  + T GD      L K+GG+G+FV+E+E
Sbjct: 6   VATRGSRLALAQTHIVCRLL--EEAGVETEIRTITTAGDRDRIHALVKIGGRGIFVREIE 63

Query: 68  VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127
             LL   ADIAVHS KD+P +   GL +     + DPRDA V      L+A   GS+VGT
Sbjct: 64  RELLSGEADIAVHSAKDLPYQLASGLVIAGTPSQADPRDALVLLKERKLEA---GSVVGT 120

Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL---ESRIR 184
            S RR  +++   P+L+ R +RGNV TRL KL+ GEYDAI+LA+AG++RL L   + +IR
Sbjct: 121 GSPRRIREISRVLPELVFRDIRGNVTTRLHKLERGEYDAIVLAMAGIQRLALDMEQFQIR 180

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L  E  +PA  QG +G+ECR  D     LL  ++  ET  R   ER + T ++  C  
Sbjct: 181 -PLSTEQVIPAGCQGIIGVECRQKDRELVRLLQQISDPETWRRFQWERQLFTSMKVDCSR 239

Query: 245 PIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           P+G +  L+  G + L A+V   DG    R  R G  ++ + +  SL EEL + 
Sbjct: 240 PVGIHCRLLKSGRMELLAMV---DGK---RARRLGMEKEGKALCASLKEELYDR 287


>UniRef50_Q46CH0 Probable porphobilinogen deaminase n=7 Tax=Euryarchaeota
           RepID=HEM3_METBF
          Length = 316

 Score =  174 bits (441), Expect = 4e-42,   Method: Compositional matrix adjust.
 Identities = 111/270 (41%), Positives = 155/270 (57%), Gaps = 11/270 (4%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG-GKGLFVKEL 66
           I TR S LAL QA  V   L A   G+   L  + T GD   D PL  V  G G FV+EL
Sbjct: 3   IGTRGSQLALAQAETVARLLKAK--GVETSLKIIKTSGDRFTDRPLHAVSSGVGAFVREL 60

Query: 67  EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126
           +  +LE + DIAVHSMKD+P   P  L  V + +R+ P D  ++ +   LD L   SI+G
Sbjct: 61  DEVMLEGKIDIAVHSMKDMPTIRPPTLPTVAVLKRDTPFDLLLTYDGTPLDELSEQSIIG 120

Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG--LESRIR 184
           TSSLRR  Q+   RPDL+ + LRGN+ TRL KL  G+YD I+LA AGL+R+G  LE  I 
Sbjct: 121 TSSLRRAAQIKRYRPDLVTQDLRGNIDTRLRKLKEGKYDGILLAKAGLERMGWELEGEI- 179

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L P+   P+  QG + +  R  ++     ++ L+H ++ +    ER + + L GGC  
Sbjct: 180 --LSPDFFCPSPNQGTIAVVTRA-ETEAEAAVSRLDHTDSRIATEIERILISELGGGCTT 236

Query: 245 PIGSYAELID--GEIWLRALVGAPDGSQII 272
           PIGSYAE++    ++ +RA V + DG + +
Sbjct: 237 PIGSYAEIMPDRKKLHVRAEVLSLDGEETV 266


>UniRef50_C2GGB5 Porphobilinogen deaminase n=2 Tax=Corynebacterium glucuronolyticum
           RepID=C2GGB5_9CORY
          Length = 290

 Score =  172 bits (437), Expect = 1e-41,   Method: Compositional matrix adjust.
 Identities = 120/299 (40%), Positives = 166/299 (55%), Gaps = 11/299 (3%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            LRI TR S LA  QA +V+D L+ +  G   EL  + T GD  L +P+ K+G  G+F +
Sbjct: 2   TLRIGTRGSKLATTQAGHVRDALIRA--GYDAELTIITTPGDKNL-SPVQKIG-VGVFTQ 57

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
            L  A+  +  DIAVHS KD+P   P+GL  +    RE P +A ++ +  +LD LP G+ 
Sbjct: 58  ALREAMDRDEIDIAVHSCKDLPTGQPEGLATIYPV-RETPCEALIARDGLTLDQLPEGAK 116

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGT + RR  QL   RPDL IR LRGNV TR+ K+ +GE DA+ILA AGL R+G      
Sbjct: 117 VGTGAPRRISQLKALRPDLDIRPLRGNVDTRMGKVTSGELDAVILAHAGLTRIGRGDEAT 176

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
               P   +PA  QG + +E R   +    +   ++ H T L   AERA+ + L+ GC  
Sbjct: 177 QVFDPTYLMPAPAQGILAVESR---THVDAISTLIDDHAT-LSAQAERAVLSTLQAGCTA 232

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           P+ +Y+ +   EI L A   A DGS+ I     G   D   +G S+AE+L   GA EI+
Sbjct: 233 PLAAYSTVSGDEITLTAGAFALDGSKQIVETATGT--DPVALGTSVAEKLRACGAEEII 289


>UniRef50_C8WDJ7 Porphobilinogen deaminase n=3 Tax=Zymomonas mobilis
           RepID=C8WDJ7_ZYMMN
          Length = 308

 Score =  172 bits (436), Expect = 2e-41,   Method: Compositional matrix adjust.
 Identities = 123/302 (40%), Positives = 169/302 (55%), Gaps = 11/302 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGL--VVELVPMVTRGDVILDTPLAKVGGKGLFV 63
            R+ +R SPLAL QA  V   L A+H      V +VP+ T GD      LA +GGK L+ 
Sbjct: 5   FRLGSRGSPLALIQARSVASALCAAHSWSEDAVVIVPIRTSGDKNRHQALADIGGKALWT 64

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KEL++AL   + D AVHSMKDV    P  + +  +  RED  D  +     SL+ LP   
Sbjct: 65  KELDIALTTGQIDAAVHSMKDVETFRPSHISIAAMLPREDVHDRLI--GIPSLEVLPYSG 122

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            VGT+S RR  Q+   RPD+ I+ LRGN+ TRL KL N ++DA +LA AGL RLG  + +
Sbjct: 123 CVGTASPRRAAQIRRIRPDIEIKLLRGNIDTRLEKLANKQFDATLLAAAGLIRLG-RNDV 181

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              +P +  LPA GQGA+GIE  L DS   E ++ ++H+ T L V +ER +  RL   C 
Sbjct: 182 GYDVPLDQMLPAAGQGAIGIEA-LADSAAWEKVSIIDHYPTHLAVQSERQLLLRLNADCH 240

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-GAPQDAEQMGISLAEELLNNGAREI 302
            PI  +AE+++  I LRA +   +G      ++    P DA ++G SL   LLN    E+
Sbjct: 241 SPIAVFAEILEKNIRLRACLYTENGKFSASIDKEISQPSDAFEVG-SL---LLNQSPPEV 296

Query: 303 LA 304
            A
Sbjct: 297 QA 298


>UniRef50_C2FZW8 Porphobilinogen deaminase n=2 Tax=Sphingobacterium spiritivorum
           RepID=C2FZW8_9SPHI
          Length = 528

 Score =  170 bits (431), Expect = 6e-41,   Method: Compositional matrix adjust.
 Identities = 115/312 (36%), Positives = 162/312 (51%), Gaps = 26/312 (8%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           ++  L I TR S LA+WQA+++KD+L A+  G+  EL  + T+GD+I    L K+ GKG 
Sbjct: 1   MNRKLIIGTRGSQLAMWQANHIKDRLAAA--GIDSELKVIKTQGDIIQHLRLDKLEGKGF 58

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD---- 117
           F KELE  LL +  D+AVHS KD+P   P GL +  + ERE P +  +    D +D    
Sbjct: 59  FTKELEEELLSSTIDLAVHSHKDLPTVNPPGLIIAAVSERESPAELLIVLK-DCVDIKKR 117

Query: 118 -ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKR 176
            +L   + VGTSS RR+ QL   RPDL    LRGN+ TR+ KL +  YDAIILA AG++R
Sbjct: 118 LSLKHNATVGTSSNRRKAQLLSLRPDLEFDDLRGNLQTRIQKLRDENYDAIILAKAGVER 177

Query: 177 --LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234
             + L       +PP   +PA  QG + I+ R  D    E L  +++ E A  +  ER +
Sbjct: 178 IDMDLSDFYVEEIPPVELIPAPAQGVLAIQIRESDQELFEALQVIHNKEVAEVIAVERKV 237

Query: 235 NTRLEGGCQVPIGSYAELIDG--EIWLRALVGA---PDGSQIIRGERRGAPQDAEQMGIS 289
               + GC  P+G Y    +G  E W      +   PD   I R    G           
Sbjct: 238 LNLFDAGCHAPLGCYCRKSEGKYEAWTSVAETSDEFPDRLYIQRDSTEG----------- 286

Query: 290 LAEELLNNGARE 301
           +AEE+    A++
Sbjct: 287 MAEEIFTKFAKD 298


>UniRef50_A8AAB4 Probable porphobilinogen deaminase n=1 Tax=Ignicoccus hospitalis
           KIN4/I RepID=HEM3_IGNH4
          Length = 304

 Score =  169 bits (429), Expect = 1e-40,   Method: Compositional matrix adjust.
 Identities = 120/297 (40%), Positives = 164/297 (55%), Gaps = 17/297 (5%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTP---LAKVGGKGLF 62
           ++IA R S L+L Q       L+   P L  E++ + T GD   + P   LAK G  GLF
Sbjct: 3   IKIAARGSKLSLKQVSMFTSYLLKFFPDLEYEVITVKTTGDKA-NAPFEELAKRGLTGLF 61

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN--NYDSLDALP 120
            KE+  A+LE +AD+AVHS+KD+P E    L +     R+ P D  +S   NYD  D LP
Sbjct: 62  EKEVNKAVLEGKADVAVHSLKDLPTELDPRLEIAAFLPRDPPYDVLISRAGNYDIFD-LP 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            GS+VGTSS RR+  +   RPDL+++ LRGNV TRL KL  GEYDAI+LA AG+ RLGL 
Sbjct: 121 KGSVVGTSSARRKALIKNLRPDLVVKDLRGNVDTRLEKLRRGEYDAIVLAEAGVSRLGLN 180

Query: 181 ---SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237
               R+   L P    P+ GQG +    R   S   +LL +++  ++    TAER +   
Sbjct: 181 VDYVRLDWRLFP----PSPGQGIIVAVTR-KGSEISDLLKSISDVKSEKLATAERTVLKE 235

Query: 238 LEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
             GGC V +G+ A      I LRA V +P G + +  E  G  +  E++G+  AE L
Sbjct: 236 FGGGCFVALGAIAFEEGSLIRLRATVLSPSGRERVDVELIG--KGPEEVGMRAAERL 290


>UniRef50_D1VCA1 Porphobilinogen deaminase n=1 Tax=Frankia sp. EuI1c
           RepID=D1VCA1_9ACTO
          Length = 380

 Score =  169 bits (429), Expect = 1e-40,   Method: Compositional matrix adjust.
 Identities = 123/344 (35%), Positives = 181/344 (52%), Gaps = 44/344 (12%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           L + LR+ TR+S LAL Q+  V D+L  +  G+ V+LV +VT GD      ++++G  G+
Sbjct: 36  LPSRLRLGTRRSALALAQSGMVADELR-TRLGIEVDLVHVVTEGDRN-RAEISQLGSTGV 93

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           +V  L  ALL    D+AVHS+KD+P   P+G+ L  I  RED RD  VS    +L  L  
Sbjct: 94  WVSALREALLSGEVDLAVHSLKDLPTAPPEGITLAAIPPREDVRDVLVSPTGRTLAQLGP 153

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ +GT + RR  QL      L +  +RGNV TR+ K  +GE DA++LA AGL RL    
Sbjct: 154 GARIGTGAPRRAAQLRALGLGLDVVPIRGNVDTRIKKAIDGEVDAVVLARAGLARLDRLD 213

Query: 182 RIRAALPPEISLPAVGQGAVGIEC---------------------------------RLD 208
            I   L PE+ LPA GQGA+ IEC                                  ++
Sbjct: 214 AITELLEPEVMLPAPGQGALAIECVATTLAPLTLLTVGTPEDQGAVTGMSCPVAPGSGVE 273

Query: 209 DSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELI---------DGEIWL 259
               R L   L+   +++ V AERA    +E GC  P+G+ A+++         +GE+ L
Sbjct: 274 IPLERLLRFVLDDAPSSVAVRAERAFLAAIEAGCTAPVGALAQVLPARGQAPASEGEVRL 333

Query: 260 RALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           RA+V + DG+ ++R E  G+  D E +G  LA++LL+ GA  ++
Sbjct: 334 RAVVASLDGTTVLRRELGGSTADPEALGRRLADDLLSAGAHTLM 377


>UniRef50_UPI0001C31A39 porphobilinogen deaminase n=1 Tax=Conexibacter woesei DSM 14684
           RepID=UPI0001C31A39
          Length = 314

 Score =  169 bits (427), Expect = 1e-40,   Method: Compositional matrix adjust.
 Identities = 132/288 (45%), Positives = 169/288 (58%), Gaps = 13/288 (4%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           +VLRI TR S LAL QA +V   L     G  VE++P+ T GD         +G K  +V
Sbjct: 2   SVLRIGTRASALALVQAEHVASLLRDG--GAQVEVIPITTSGDRGR-----LLGDKSRWV 54

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KELE ALL +  D+AVHS KDVP E P G  L  +  R D RDA       SL+ LP G+
Sbjct: 55  KELEAALLADEVDVAVHSAKDVPAELPDGFVLAGVPARADARDALC--GAASLEQLPDGA 112

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           +VGTSSLRR  +L   RPDL + +LRGNV TRL KL +G+  AI+LAVAGL+RL   + I
Sbjct: 113 VVGTSSLRRAAELRALRPDLGVVALRGNVDTRLRKLADGQAAAIVLAVAGLERLDRGAAI 172

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
            A L  +  +PA GQGA+ +E R DD R R   AA+   + A  + AERA+  RL   C 
Sbjct: 173 GAVL--DQLVPAPGQGALALETRADDDRARAAAAAITDADAAACLAAERALVRRLGATCH 230

Query: 244 VPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAPQ-DAEQMGIS 289
            P+G++A    DG + LR+ VG PDGS  +R E   A   D E  G++
Sbjct: 231 TPLGAHAVRTADGGLRLRSFVGLPDGSAWLRDELSAAAGIDPETFGVA 278


>UniRef50_A9V9E0 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V9E0_MONBE
          Length = 643

 Score =  168 bits (426), Expect = 2e-40,   Method: Compositional matrix adjust.
 Identities = 101/206 (49%), Positives = 125/206 (60%), Gaps = 8/206 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR S LA+WQ  +V ++L  +HPG+   +VP+ T GD  L   L K    G+F   
Sbjct: 417 IRIGTRSSVLAMWQTRWVVERLTRAHPGVRFSVVPLSTVGDANLTLDLNKFSTTGIFTDA 476

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS----LDALPA 121
           L  ALL    DI VHS+KD+P     G  L  I  REDPRD  V ++  S    L  LPA
Sbjct: 477 LVRALLAQEVDILVHSLKDLPSTISPGTQLAAIGPREDPRDVVVFHHRHSEIKDLAQLPA 536

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD---NGEYDAIILAVAGLKRLG 178
           G++VGTSS RR+ QLA   P L    +RGNV TRL KLD   NG YDA+ LA AGL RLG
Sbjct: 537 GAVVGTSSTRRRAQLAAAYPQLRFAPVRGNVMTRLRKLDDPANG-YDALCLAAAGLIRLG 595

Query: 179 LESRIRAALPPEISLPAVGQGAVGIE 204
           LE+RI   LP  +S  A+GQGA+GI+
Sbjct: 596 LEARIGQFLPLTVSRHAIGQGALGIQ 621


>UniRef50_B5JN62 Porphobilinogen deaminase n=1 Tax=Verrucomicrobiae bacterium DG1235
           RepID=B5JN62_9BACT
          Length = 291

 Score =  168 bits (426), Expect = 2e-40,   Method: Compositional matrix adjust.
 Identities = 106/243 (43%), Positives = 132/243 (54%), Gaps = 11/243 (4%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67
           IATR+SPLA+ Q H  K+      P  V  +  MVT GD   +  L K GGKGLF KELE
Sbjct: 10  IATRKSPLAMAQTHLAKELFQRGMPDAVFRIEKMVTTGDKRQEWSLEKQGGKGLFTKELE 69

Query: 68  VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127
            ALLE RAD AVHS KD+P E P+GL L     R+   D  +       D + +  ++ T
Sbjct: 70  DALLEGRADFAVHSAKDLPSEMPKGLALAGFLPRQTCEDVLILR-----DGVESPKLIAT 124

Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR---IR 184
            S RR+ QL    P      +RGNV TRL+K+  G+ DA +LA AGL RLG+ES      
Sbjct: 125 GSPRRRIQLRYLFPKAEFTEIRGNVDTRLTKIARGDADATVLASAGLNRLGIESWEGVTF 184

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L  +  +PAVGQ AV I+CR +D  T     A    ETA+ V  ER+    L GGCQV
Sbjct: 185 RKLTLDECVPAVGQAAVAIQCREEDVDT---FRAHLDEETAIAVNLERSFLEELGGGCQV 241

Query: 245 PIG 247
              
Sbjct: 242 AFA 244


>UniRef50_D1C4S0 Porphobilinogen deaminase n=1 Tax=Sphaerobacter thermophilus DSM
           20745 RepID=D1C4S0_SPHTD
          Length = 311

 Score =  167 bits (422), Expect = 5e-40,   Method: Compositional matrix adjust.
 Identities = 117/259 (45%), Positives = 147/259 (56%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +R+ TR S LA  Q   V   L A  P L +    + T GD    TPL  +GG+G+F +E
Sbjct: 11  VRLGTRGSALAREQTRRVMAALAALRPDLELIETIVSTAGDRDKRTPLTVIGGQGVFARE 70

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L+ ALL    D+AVHS KD+P E   GL +     RED RD  VS +  SL  LP G+ V
Sbjct: 71  LQTALLAGTVDVAVHSAKDLPTEPVPGLVIGAFFSREDARDVLVSRDGRSLADLPPGARV 130

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS RR   L   RPDL    LRGN+ TRL K+  GE DA ILA AGL R+G +  I  
Sbjct: 131 GTSSRRRLVALRRLRPDLEAVDLRGNLDTRLRKVREGEVDAAILAAAGLLRMGWQEHITE 190

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L  +  +PA GQGA+ IECR DD    E+LAALN    AL    ER+    L GGC+ P
Sbjct: 191 FLSLDDFVPAPGQGALAIECRADDPAVNEMLAALNDPAAALAARTERSFLRALGGGCRSP 250

Query: 246 IGSYAELIDGEIWLRALVG 264
           IG++A +    + LR ++G
Sbjct: 251 IGAHATVSGDTVTLRVMLG 269


>UniRef50_B6W7F3 Putative uncharacterized protein n=1 Tax=Anaerococcus hydrogenalis
           DSM 7454 RepID=B6W7F3_9FIRM
          Length = 318

 Score =  167 bits (422), Expect = 5e-40,   Method: Compositional matrix adjust.
 Identities = 109/310 (35%), Positives = 163/310 (52%), Gaps = 12/310 (3%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           +++I +R S LAL QA+ VKD L     GL  ++V + T+GD I D  + ++  KG+FV+
Sbjct: 1   MIKIGSRASKLALIQANMVKDIL--EKEGLEAQIVEISTKGDRIRDRKIDQLNSKGVFVR 58

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALPAGS 123
           E+E  LL+   DIAVHS+KD+P +    L      + EDPRD FV  + +  +D L   +
Sbjct: 59  EIEEKLLDKTIDIAVHSLKDMPSQIDDRLIFTPPLKGEDPRDCFVGKDVFKKMDDL-NNA 117

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           +VGT S RR CQ      ++  +++RGNV TR+ K+ +   D +ILA +GL R GL+  I
Sbjct: 118 LVGTGSNRRVCQGKNHFSNIKFKAIRGNVETRIKKVQSENLDGVILAKSGLIRAGLDGEI 177

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              L P I  P+  QG +GIE R +D +  E+    +  +T  R+  ERA    L   C 
Sbjct: 178 NFDLDPHIFTPSPCQGILGIEIRKEDKKLFEIFKKNSDEKTLFRMETERAFQKELGADCS 237

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
            P+G + E+   +I L   + A D    I  ER           I LA++L    AR + 
Sbjct: 238 TPMGIFTEIDHDKITLTGSM-AFDKDDRINYERVSGNISER---IHLAQKL----ARTLK 289

Query: 304 AEVYNGDAPA 313
            + Y  + P 
Sbjct: 290 KKSYKKNNPC 299


>UniRef50_Q6AHF1 Porphobilinogen deaminase n=5 Tax=Actinobacteria (class)
           RepID=HEM3_LEIXX
          Length = 329

 Score =  166 bits (421), Expect = 8e-40,   Method: Compositional matrix adjust.
 Identities = 121/315 (38%), Positives = 168/315 (53%), Gaps = 21/315 (6%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             LR+ TR SPLA+ Q   V    +A   G  +ELV + T GD   ++ L+++GG G+F 
Sbjct: 13  GALRVGTRGSPLAVAQTQAVS-AAVARATGFDIELVTVTTHGDTSRES-LSELGGTGVFA 70

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
             L  AL     D+ VHS+KD+P     GL L  + +R D RD   + +      LP G+
Sbjct: 71  TALRDALRNGECDLVVHSLKDLPTAPAPGLVLGAVPKRADARDTLCARDGLRFGELPEGA 130

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            VGT S RR  QL  +RP L I  +RGNV TRLS++  G+ DA++LA AGL RLG   R+
Sbjct: 131 SVGTGSPRRAAQLRAQRPGLDIVDIRGNVDTRLSRVSAGDLDAVVLAAAGLGRLG---RL 187

Query: 184 RAA--LPPEISLP-AVGQGAVGIECRLDDSRTR----ELLAALNHHETALRVTAERAMNT 236
            AA       ++P A GQGA+ +E R  D R R      LAA++H  T    TAERA+  
Sbjct: 188 DAATDFFSLSTMPTAPGQGALALEVREGDERGRGPIARALAAVDHATTCAATTAERAVLA 247

Query: 237 RLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAP---------QDAEQMG 287
            LE GC  P+G+ A + DG ++L A V  PDG+  +       P         + A  +G
Sbjct: 248 GLEAGCAAPVGATAMIDDGLLFLTATVYRPDGAAQLTASHAATPDSFGAAHLDEAARDVG 307

Query: 288 ISLAEELLNNGAREI 302
             +  ELL +GA ++
Sbjct: 308 ERVVAELLASGAADL 322


>UniRef50_C5C5B3 Porphobilinogen deaminase n=6 Tax=Actinomycetales
           RepID=C5C5B3_BEUC1
          Length = 334

 Score =  166 bits (419), Expect = 1e-39,   Method: Compositional matrix adjust.
 Identities = 119/270 (44%), Positives = 155/270 (57%), Gaps = 13/270 (4%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMA-----SHPGLVVELVPMVTRGDVILDTPLAKVGGK 59
            LR+ TR S LA  Q+ +  + + A     +   + VELV + T GDV+  + LA +GG 
Sbjct: 21  TLRVGTRASALATTQSEWAGEAIAARVAAATGSDVEVELVRVTTTGDVLTGS-LASMGGT 79

Query: 60  GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119
           G+FV  L  ALL+ R D+AVHS+KD+P     GL L  + +REDPRD   +     L  L
Sbjct: 80  GVFVTALREALLDGRCDVAVHSLKDLPTAAAPGLVLGAVPQREDPRDVLCARAGAGLADL 139

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLKRL 177
           PAG  VGT S RR  QL   RPDL I  +RGNV TRLS++    G+ DA++LA AGL RL
Sbjct: 140 PAGGRVGTGSPRRAAQLRRARPDLEIVDIRGNVDTRLSRISPGKGDLDAVVLARAGLARL 199

Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHE---TALRVTAERAM 234
           G    +  AL   + +PA GQGA+ +E    D+    LLA L   +   T L VTAERAM
Sbjct: 200 GRLDAVTEALDAGVMVPAPGQGALAVEAV--DAAPDWLLAGLRAFDDAPTRLAVTAERAM 257

Query: 235 NTRLEGGCQVPIGSYAELIDGEIWLRALVG 264
             RLE GC  P+G+ A L   ++ LR  VG
Sbjct: 258 LARLEVGCSAPVGALATLAGSQLLLRTSVG 287


>UniRef50_A6LKX0 Porphobilinogen deaminase n=1 Tax=Thermosipho melanesiensis BI429
           RepID=A6LKX0_THEM4
          Length = 279

 Score =  164 bits (415), Expect = 4e-39,   Method: Compositional matrix adjust.
 Identities = 94/247 (38%), Positives = 143/247 (57%), Gaps = 6/247 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +R+ TR+S LAL Q   V +KL    P +  E+ P+VT+GD  L TP+ K+GGKG+FV +
Sbjct: 3   IRVGTRKSKLALIQTQLVVNKLKELLPNIDFEITPVVTKGDR-LKTPIDKIGGKGVFVSD 61

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E  +L+++ DIA+HSMKD+P + P  L L ++ +RE P D F+    ++   L  G+ +
Sbjct: 62  IEKLILDDKLDIAIHSMKDLPSKIPDKLFLTSVLKRECPNDVFIGK--ENFFNLKKGAKI 119

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS RR  Q+   RPD+ I  +RGNV TR+ K+  GE D I++A AG+ RLGL+ +I  
Sbjct: 120 GTSSKRRALQINMLRPDIEIVPIRGNVDTRIKKI--GELDGIVIAAAGVIRLGLKDKITN 177

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSR-TRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
               E  +PA  QG + +E      +   E+   +   +T +    ER + + L   C  
Sbjct: 178 LFEFEKIVPAPCQGILALEFSEKFLKPFEEIKDVIVDPKTEVETQIERKILSLLNFDCNT 237

Query: 245 PIGSYAE 251
           P G Y +
Sbjct: 238 PFGFYCD 244


>UniRef50_Q5KKQ0 Hydroxymethylbilane synthase, putative n=2 Tax=Filobasidiella
           neoformans RepID=Q5KKQ0_CRYNE
          Length = 481

 Score =  164 bits (415), Expect = 4e-39,   Method: Compositional matrix adjust.
 Identities = 106/288 (36%), Positives = 142/288 (49%), Gaps = 37/288 (12%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPG-------------------------LVVEL 38
           N   + TR+S LAL Q  +V D L   H G                             +
Sbjct: 31  NTFILGTRKSNLALVQTGHVADDLRRLHSGAGSKFGETREEGDDAEQGDVPFVHPYTFSI 90

Query: 39  VPMVTRGDVILDTPL-------AKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQ 91
             M T GD    TPL       +    K L+  ELE  L+    D+ VHS+KDVP     
Sbjct: 91  ESMTTVGDRNQTTPLHLLSPYSSTQPAKSLWTDELEARLINGHFDMLVHSLKDVPTVLKD 150

Query: 92  GLGLVTICEREDPRDAFVSNN---YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSL 148
           G  +  + +R DPRDA V      Y  L+ LP G++VGT S+RR  QL    P+L+   +
Sbjct: 151 GCEIGCMAKRHDPRDALVVKQGLPYKRLEDLPDGAVVGTGSVRRVAQLKRAFPNLVFEDM 210

Query: 149 RGNVGTRLSKLDNGE--YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECR 206
           RGN+ TR +KLDN +  + A+ILA++GL+RLG+  R  + L     + AVGQGA+ IE R
Sbjct: 211 RGNLNTRFNKLDNPQSPFSALILAMSGLERLGMAHRATSPLSSPTLMHAVGQGALAIEIR 270

Query: 207 LDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID 254
             D R R  L  L H +T     AER     LEGGC VP+G  +EL++
Sbjct: 271 STDPRVRNCLRGLGHWQTEWSCGAERGCLRVLEGGCSVPVGVESELVE 318


>UniRef50_A4WN24 Probable porphobilinogen deaminase n=3 Tax=Thermoproteaceae
           RepID=HEM3_PYRAR
          Length = 297

 Score =  164 bits (414), Expect = 5e-39,   Method: Compositional matrix adjust.
 Identities = 102/247 (41%), Positives = 142/247 (57%), Gaps = 2/247 (0%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L +ATR S L++ Q   +  ++ A  P +  E+  + T GD + D PL ++G KG+F KE
Sbjct: 3   LVVATRGSKLSMLQTEELLAQIKAVEPSIEFEIKIVKTTGDEVQDKPLYQIGVKGIFEKE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           + +A+L   AD+AVHS+KD+P E   GL L    +R  P DA VS     L+ LP G++V
Sbjct: 63  VNLAVLRGEADVAVHSLKDLPSELSPGLVLAGFSKRAPPFDAVVSTAGYVLETLPRGALV 122

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL-GLESRIR 184
           GTSS+RR   +   RPD+ +  LRGNV TR++K+  G+YDA I+AVAG+ RL G    I+
Sbjct: 123 GTSSVRRAEFVKAIRPDVRVEPLRGNVDTRINKILQGKYDAAIMAVAGIYRLYGASPPIK 182

Query: 185 -AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
            A L PE+  P  GQG V    R  DS   +LL   +  + +L   AER     +  GC 
Sbjct: 183 LAVLRPEVLPPPPGQGIVAAVVREADSWLIDLLKKASDPKASLEAIAEREFLKAVGAGCH 242

Query: 244 VPIGSYA 250
           V IG  A
Sbjct: 243 VAIGGVA 249


>UniRef50_B2ULP1 Porphobilinogen deaminase n=1 Tax=Akkermansia muciniphila ATCC
           BAA-835 RepID=B2ULP1_AKKM8
          Length = 325

 Score =  163 bits (413), Expect = 6e-39,   Method: Compositional matrix adjust.
 Identities = 126/318 (39%), Positives = 164/318 (51%), Gaps = 27/318 (8%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG------ 57
           N L I TR S LAL QA  V+  L   +P L V    + T GD   D PLA V       
Sbjct: 5   NTLIIGTRGSALALAQADMVRAALSLRYPELDVRCEIIHTIGDRRTDVPLADVARVSGMV 64

Query: 58  GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD 117
            KG+F+KELE AL + R D+AVHS+KDVP E   G  L  +  R    D  ++   D   
Sbjct: 65  DKGIFIKELETALRDGRIDVAVHSLKDVPSELAAGFTLAAVLPRAAVEDVLITKEPDWNG 124

Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-DNGEYDAIILAVAGLKR 176
           +   G++   S  RR          L   +LRGNV TRL KL ++  +DA+ILA AGL+R
Sbjct: 125 S---GTLATGSVRRRLMARTYWGSGLRFENLRGNVPTRLGKLVEHPGWDAVILARAGLER 181

Query: 177 LGL---ESRIRA------ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALR 227
           LGL   E+ +         LP E+ +PAVGQG VG+ECR  D  T E+L  +N  E+   
Sbjct: 182 LGLYAPETLVEGRKLYMRPLPVEVFIPAVGQGIVGMECRSSDRETAEMLEGINDPESFAC 241

Query: 228 VTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQ----IIRGERRGAPQDA 283
             AERA   RL   C  P+G YA     E+ LRA    P   +    +IRG+R+ AP   
Sbjct: 242 ALAERAFLVRLGANCSTPVGVYAHPDGEELVLRAAYYVPGREEPFAVVIRGDRK-AP--- 297

Query: 284 EQMGISLAEELLNNGARE 301
           E +G+   EEL  +G R+
Sbjct: 298 EALGLRAFEELGLSGWRK 315


>UniRef50_B0WMK9 Porphobilinogen deaminase n=1 Tax=Culex quinquefasciatus
           RepID=B0WMK9_CULQU
          Length = 474

 Score =  162 bits (411), Expect = 1e-38,   Method: Compositional matrix adjust.
 Identities = 99/246 (40%), Positives = 136/246 (55%), Gaps = 29/246 (11%)

Query: 12  QSPLALWQAHYVKDKLMASHPGLVVEL------------VP------------MVTRGDV 47
            S LAL Q  YV   L   +P +V E+            VP            M T GD 
Sbjct: 166 HSKLALIQTKYVISCLQKLNPDVVYEIRKYFQHVHLCWHVPSYLLAFFLSPDTMTTVGDR 225

Query: 48  ILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDA 107
           +L+  L K+G K LF K+LE AL     D  VHS+KD+P   P G+ +  + ER+DPRDA
Sbjct: 226 VLNKSLPKIGEKSLFTKDLEDALRTGGVDFVVHSLKDLPTALPLGMAIGAVLERDDPRDA 285

Query: 108 FVSNNYD---SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--DNG 162
            V N      +L  LP GS+VGTSSLRR  QLA +  ++++  +RGN+ TRL+KL  D  
Sbjct: 286 LVLNEAHRGRTLSTLPKGSVVGTSSLRRSAQLARKYENVVVCDIRGNLNTRLAKLDADGS 345

Query: 163 EYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHH 222
           ++  IILA AGL R+G  +R+   + P   L AVGQGA+ +ECR +D    ++L+ L H 
Sbjct: 346 KFAGIILAQAGLVRMGWNARVSQVIEPGEILYAVGQGALAVECRSNDEYILDMLSKLCHL 405

Query: 223 ETALRV 228
           ET  ++
Sbjct: 406 ETQCKI 411


>UniRef50_B3LB83 Porphobilinogen deaminase, putative n=1 Tax=Plasmodium knowlesi
           strain H RepID=B3LB83_PLAKH
          Length = 449

 Score =  162 bits (410), Expect = 1e-38,   Method: Compositional matrix adjust.
 Identities = 109/380 (28%), Positives = 176/380 (46%), Gaps = 80/380 (21%)

Query: 8   IATRQSPLALWQAHYVKDKLMAS----HPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           I TR SPLA+ Q+  V+ KL A     +  + + L  + T GD ILD  +   GGKG+F 
Sbjct: 69  IGTRDSPLAIKQSEKVRTKLEAYFKKVNKNVKITLKSIKTMGDNILDQKVDLFGGKGIFT 128

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL---- 119
           KEL+  L++ +  I VHS+KDVP+E P+ + L    +R+   DAF+S  Y +L+ +    
Sbjct: 129 KELDEELIKGKVHICVHSLKDVPMELPEQVQLSCFLKRDTINDAFLSVKYGTLEDMNKMK 188

Query: 120 -----------PAGS------------------------IVGTSSLRRQCQLAERRPDLI 144
                      P G                          +GTSSLRR  Q+  +  ++ 
Sbjct: 189 MANKMEEGSYQPKGMSQRVINQNVKRDNYEGDHYDNFIPTIGTSSLRRSSQIKYKYKNVA 248

Query: 145 IRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAAL----------------P 188
           ++++RGN+ TR++KL NG+YDAII+A  GL+RL  +  IR  +                 
Sbjct: 249 VKNMRGNINTRIAKLCNGQYDAIIIAKCGLERLTTKKGIRNIIGGKNKVTPKNFLINYNN 308

Query: 189 PEISL--------------PAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234
            EI+L              PA+ QG + +     D    ++L  +N  +  +    ER+ 
Sbjct: 309 TEINLTSLHIQQINKRTIYPALCQGIIAVSSHKSDKYISDVLKNINDEKAQIMANIERSF 368

Query: 235 NTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
             ++EG C +PIG YA++++GEI   A++    G +       G  +   ++ +  A ++
Sbjct: 369 LYQIEGNCMMPIGGYAKIVNGEIVFNAVINDIHGREKYHVREVGKVESYNEIAVMAATKM 428

Query: 295 LN-------NGAREILAEVY 307
                    N  RE  A+ Y
Sbjct: 429 KEKIGTHRFNKIREEAAQYY 448


>UniRef50_Q57989 Probable porphobilinogen deaminase n=11 Tax=Methanococcales
           RepID=HEM3_METJA
          Length = 292

 Score =  159 bits (402), Expect = 1e-37,   Method: Compositional matrix adjust.
 Identities = 95/246 (38%), Positives = 138/246 (56%), Gaps = 5/246 (2%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           ++RI TR S LAL+QA+ V +  +  + G  VE+  + T GD +LD  L+ +G  G+F K
Sbjct: 1   MIRIGTRGSKLALYQANKVAE--LLKNLGYKVEIKIIKTTGDRVLDKKLSDIG-IGVFTK 57

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           EL++A+L N  DIAVHS+KD+P  + + L +  + ER+   D  + N     +   +  +
Sbjct: 58  ELDLAMLNNEIDIAVHSLKDIPTIWNENLMVGAVLERDSYHDLLIWNKDIDFNE-DSKIV 116

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GTSS+RR+  L    P+     LRGNV TRL KL  G YDAI+L+ AG+ RLG+     
Sbjct: 117 IGTSSMRRRAFLKFIYPNAKFELLRGNVDTRLRKLKEGLYDAIVLSEAGIIRLGVSLEDF 176

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
                +I LPA  QG + + C+ DD   + +L  +NH  T L    ER       GGC V
Sbjct: 177 NYKRLDI-LPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSV 235

Query: 245 PIGSYA 250
           P G+ A
Sbjct: 236 PFGALA 241


>UniRef50_Q2FTK7 Hydroxymethylbilane synthase n=3 Tax=Methanomicrobiales
           RepID=Q2FTK7_METHJ
          Length = 295

 Score =  158 bits (400), Expect = 2e-37,   Method: Compositional matrix adjust.
 Identities = 111/288 (38%), Positives = 164/288 (56%), Gaps = 14/288 (4%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LR+ TR S LA  QA  VK   M    G+  ELV + T GD     PL ++GG+G+FV+ 
Sbjct: 3   LRVGTRASELAKAQA--VKVCTMLEDLGVDTELVFISTAGDEQTGVPLHEIGGQGVFVRA 60

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L+ AL++N+ D+AVHSMKD+P E P GL    I  R+ P D  V+++   LD +   + +
Sbjct: 61  LDDALVQNKIDLAVHSMKDIPAERPYGLVTSAILARDSPCDYIVTDH--ELDEI---TTL 115

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS RR  Q     P   IR LRGNV TRLSKL +GEYDAI+LA AGL+RL + +    
Sbjct: 116 GTSSTRRTAQCRRNLPWADIRPLRGNVNTRLSKLQSGEYDAIMLAKAGLERLSM-TLDGY 174

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L P + +P+  QG + +  R D   T ++++ ++  +T +    ER +   + GGC  P
Sbjct: 175 QLDPRVHVPSPNQGTIAVVSRTDPDVT-DIISKIDDPKTRMDTLLERRVMEMIGGGCFTP 233

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAP-QDAEQMGISLAE 292
           +G Y +    +  + A V + +G +  R ER  +   DA++ G+ + E
Sbjct: 234 LGIYCK----DRLMIAEVLSLEGDRHFRLERLVSDIDDADRFGLEVRE 277


>UniRef50_O26960 Probable porphobilinogen deaminase n=1 Tax=Methanothermobacter
           thermautotrophicus str. Delta H RepID=HEM3_METTH
          Length = 289

 Score =  158 bits (399), Expect = 3e-37,   Method: Compositional matrix adjust.
 Identities = 106/288 (36%), Positives = 160/288 (55%), Gaps = 10/288 (3%)

Query: 10  TRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVA 69
           TR S LAL Q ++V + +++      +E   + T+GD I D+ L  +  +GLF +EL++A
Sbjct: 5   TRGSRLALVQTNHVIE-MLSEVCKEKIEKKIIKTKGDRIRDSQLYSMDSRGLFTRELDMA 63

Query: 70  LLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSS 129
           +L    D+AVHS+KDVP +    L +  +  RE P +  VS   D  D LP GS +GTSS
Sbjct: 64  VLNEEVDLAVHSLKDVPSDLDPDLAIAAVPPRESPAEVLVSR-LDWED-LPQGSKLGTSS 121

Query: 130 LRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPP 189
           LRR+      + +  +  LRGN+ TR+ K+ +GE  A I+A AGLKRLGLE  I+   P 
Sbjct: 122 LRREAFCNHHQKNFKMEPLRGNIDTRIRKVMDGEVHATIMAEAGLKRLGLEEHIKRRFPV 181

Query: 190 EISLPAVGQGAVGIECRLDDSRTRELLAA---LNHHETALRVTAERAMNTRLEGGCQVPI 246
           E   PA GQGA+ +  R D     EL+++   + HH +   VTAE+ +   L  GCQ P+
Sbjct: 182 EYFTPAAGQGALAVITRADS----ELISSIGRITHHPSLQEVTAEKTLLRELGAGCQCPL 237

Query: 247 GSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
           G        ++ L A++   +G  + +   RG   +AE +G   A+E+
Sbjct: 238 GVIGRATGNQLTLYAVLLTREGEMLRKVTVRGPLAEAEDIGKKAAKEM 285


>UniRef50_A4YD92 Probable porphobilinogen deaminase n=1 Tax=Metallosphaera sedula
           DSM 5348 RepID=HEM3_METS5
          Length = 290

 Score =  158 bits (399), Expect = 3e-37,   Method: Compositional matrix adjust.
 Identities = 113/296 (38%), Positives = 159/296 (53%), Gaps = 14/296 (4%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RIA R S L+L Q   V   L A   G   E + + T+ D+  + PL ++G KG+F KE
Sbjct: 3   IRIAARGSKLSLKQVEIVTTYLQAK--GYETEFIEIKTKADLFGNKPLHEIG-KGVFEKE 59

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +  A+L+ RADIAVHSMKD+  E P GL L+   +RE+P D  VS    +L+ LP  S +
Sbjct: 60  VNEAVLQGRADIAVHSMKDMSSELPPGLELLATPKRENPVDVLVSEL--NLEELPEKSRI 117

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GT SLRR   L   RPDL++ ++RGNV TRL K  + EYD IILA AGL+RLG+E + R 
Sbjct: 118 GTGSLRRANFLKVVRPDLVVENIRGNVDTRLRKYRDHEYDGIILAEAGLRRLGVEVK-RF 176

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L  E   P   QG + +   +   +   L   LN   T     AE+     + GGC  P
Sbjct: 177 PLDVESFTPEPNQGIIAV---VGSPKFLGLFQELNDTGTMKEALAEKETVKVVGGGCHSP 233

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQ--IIRGERRGAPQDA-EQMGISLAEELLNNG 298
           +G    L D    L  +    +G +   ++   R +PQ A  Q+G +L + + + G
Sbjct: 234 LGVLFRLEDD--VLHGIASYSNGVKRVTVKLSTRESPQIAGNQLGKALVKAMKDEG 287


>UniRef50_A1DGB8 Porphobilinogen deaminase n=1 Tax=Neosartorya fischeri NRRL 181
           RepID=A1DGB8_NEOFI
          Length = 363

 Score =  156 bits (395), Expect = 8e-37,   Method: Compositional matrix adjust.
 Identities = 120/344 (34%), Positives = 166/344 (48%), Gaps = 39/344 (11%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMAS-HPGLVVELVPMVTRGDVILDTPLAKVG---- 57
           + V+    R+S LAL Q  +V  KL  +  P    ++      GD     P A +     
Sbjct: 20  EEVVIFGCRKSELALVQTRWVTSKLGQTLDPSPTFQIATGSAVGDADKQAPFAVLSKLTG 79

Query: 58  ----GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN- 112
               GK L+  ELE+ L+  +    VHS+KD+P   P    L  + ERED  DA    + 
Sbjct: 80  GSDIGKSLWTNELELDLVAGKVHCLVHSLKDMPTTLPPHCLLGAVPEREDCSDAVCMRSD 139

Query: 113 --YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAII 168
             + S+D LP GSIVGTSS RR+  +    P L +   RGNV TRL+KLD  +  +  I+
Sbjct: 140 LKFTSIDQLPPGSIVGTSSSRRKALVRRNWPHLEVVECRGNVDTRLAKLDAPSSRFSCIL 199

Query: 169 LAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRV 228
           LA AGL RLGL  RI   L   I   AVGQGA+G+E   D     EL+  ++H  +  R 
Sbjct: 200 LATAGLLRLGLGHRITHRLDDSIFPYAVGQGALGLEVSTDRPDILELVRHVDHKPSRWRG 259

Query: 229 TAERAMNTRLEGGCQVPIGSYAEL----------------------IDGEIWLRALVGAP 266
            AERAM   L+GGC  PIG  + L                        G + LRA+V   
Sbjct: 260 IAERAMLRSLQGGCSSPIGVQSSLEPLGKEENGSTEDDSQRGRDSSSGGNLSLRAMVLHI 319

Query: 267 DGSQIIRGERRG---APQDAEQMGISLAEELLNNGAREILAEVY 307
           +G+  I  E        ++AE +G+S+A  LL  GAR ++ + +
Sbjct: 320 EGTSEIVAEDMATVRCDEEAELLGVSVANMLLAKGARGLMPKQF 363


>UniRef50_D1B7N1 Porphobilinogen deaminase n=1 Tax=Thermanaerovibrio acidaminovorans
           DSM 6589 RepID=D1B7N1_THEAS
          Length = 307

 Score =  156 bits (395), Expect = 8e-37,   Method: Compositional matrix adjust.
 Identities = 120/304 (39%), Positives = 163/304 (53%), Gaps = 18/304 (5%)

Query: 10  TRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVA 69
           TR SPLA+ QA   KD++ +   G  V L+ + T GD      LA  GG G FVK LE  
Sbjct: 8   TRSSPLAMAQARMWKDRIESL--GHSVRLLDVSTHGDRDRRRHLACFGGFGAFVKALEDR 65

Query: 70  LLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSS 129
           LL  +   AVHS+KDVP   P GL +  + ER    D  V+    SL+ LP+G+++GTSS
Sbjct: 66  LLSGQGHGAVHSLKDVPSVQPDGLVIAGVLERGPRGDVLVTREGLSLEELPSGAVIGTSS 125

Query: 130 LRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPP 189
           +RR  Q+   R DL +   RGNV +RL KL+ G +  I+LA AGL+RLG+  R   A  P
Sbjct: 126 IRRAAQVRMLRGDLNVECCRGNVHSRLRKLEQGLFHGIVLARAGLERLGI--RAPMAELP 183

Query: 190 EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSY 249
            I+ P  GQGAV +E R + S    L A L H  T L V AER+       GC  P+ + 
Sbjct: 184 FITSP--GQGAVALEAR-EGSELHLLGARLTHRSTWLEVLAERSFLKAFGMGCSAPVAAS 240

Query: 250 AELIDGEIWLRALVGAPDGSQIIRGERRGAP---QDAEQMG------ISLAEELLNNG-- 298
           A +    + L+  V +P+G+     E    P   +DA  +G      IS + E+L+ G  
Sbjct: 241 AVMDRDTLTLKVQVLSPNGTSAAEAEVSCVPWGEEDAYALGEAAFREISGSPEVLSAGSA 300

Query: 299 AREI 302
           ARE+
Sbjct: 301 AREV 304


>UniRef50_A2SQU4 Uroporphyrin-III C-methyltransferase n=11 Tax=Euryarchaeota
           RepID=A2SQU4_METLZ
          Length = 542

 Score =  154 bits (390), Expect = 3e-36,   Method: Compositional matrix adjust.
 Identities = 102/249 (40%), Positives = 141/249 (56%), Gaps = 12/249 (4%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR S LAL Q   V   L  +  G+  E V + T GD + D  L ++GG G+FV+E
Sbjct: 4   IRIGTRGSKLALAQTKKVIGLL--AENGIDAEYVIIKTTGDKVTDRGLHQIGGFGMFVRE 61

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L+ A+L    D AVHSMKD+P E P+GL  V + +R+ P D  V N    ++ L    ++
Sbjct: 62  LDNAILRGEIDCAVHSMKDIPAERPKGLLTVAVLKRDPPYDFLVMNG--KVEDL---MVI 116

Query: 126 GTSSLRRQCQL---AERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           GTSSLRR+ QL       P + +  LRGN+ TRL KLD+G YD I++A AGL RL  + R
Sbjct: 117 GTSSLRRKAQLLRYFHNCPAVRVEMLRGNLDTRLGKLDDGLYDGIMVAEAGLMRLDYK-R 175

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
               L P++ +PA  QG + I  R D    R   A LN  ++AL    ER +  ++ GGC
Sbjct: 176 NGVRLSPDMFVPAANQGTIAIVSR-DTPELRAAFAPLNDPQSALDCAIERIVMEQVGGGC 234

Query: 243 QVPIGSYAE 251
             P+G + E
Sbjct: 235 FTPMGIFCE 243


>UniRef50_Q8I5V3 Porphobilinogen deaminase n=6 Tax=Plasmodium RepID=Q8I5V3_PLAF7
          Length = 435

 Score =  154 bits (389), Expect = 3e-36,   Method: Compositional matrix adjust.
 Identities = 92/341 (26%), Positives = 160/341 (46%), Gaps = 61/341 (17%)

Query: 8   IATRQSPLALWQAHYVKDKLMAS----HPGLVVELVPMVTRGDVILDTP-LAKVGGKGLF 62
           I TR SPLAL Q+  V+ K+M+     +  + V    + T GD ILD+  +   GGKG+F
Sbjct: 64  IGTRDSPLALKQSEKVRKKIMSYFKKMNKNINVTFKYIKTTGDNILDSKSVGLYGGKGIF 123

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122
            KEL+  L+    D+ VHS+KDVP+  P  + L    +R+   DAF+S  Y S++ +   
Sbjct: 124 TKELDEQLINGNVDLCVHSLKDVPILLPNNIELSCFLKRDTINDAFLSIKYKSINDMNTV 183

Query: 123 S------------------------IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSK 158
                                     +GTSSLRR+ Q+  R  ++ + ++RGN+ TR+ K
Sbjct: 184 KSVSKTEDIHHINKKDSDHNNDTLCTIGTSSLRRRSQIKNRYKNIYVNNIRGNINTRIEK 243

Query: 159 LDNGEYDAIILAVAGLKRLGLESRIR--------------------------------AA 186
           L NGE DA+I+A+ G++RL  ++ ++                                  
Sbjct: 244 LYNGEVDALIIAMCGIERLIKKANLKHLLKNKEQKNICQPFLLKCNNKKCIDLCHVNIQK 303

Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246
           L   +  PA+GQG + +     +     LL  +N+ ++ +    ER+    ++G C +PI
Sbjct: 304 LNKNLIYPALGQGIIAVTSHKKNYFISSLLKNINNKKSEMMAQIERSFLYHIDGNCMMPI 363

Query: 247 GSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMG 287
           G Y  + + +I+L  ++    G    +  ++    + +++G
Sbjct: 364 GGYTNMRNEDIYLHVIINDIHGYNKYQVTQKDTLYNYKEIG 404


>UniRef50_Q2NEP4 HemC n=4 Tax=Methanobacteriaceae RepID=Q2NEP4_METST
          Length = 290

 Score =  153 bits (387), Expect = 7e-36,   Method: Compositional matrix adjust.
 Identities = 95/294 (32%), Positives = 156/294 (53%), Gaps = 12/294 (4%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67
           + TR S LA  Q   V   L       +   + + T GD I ++ L  +  KG+F KEL+
Sbjct: 3   VGTRGSKLATTQTKTVVKALEEITGEEIETKI-IKTTGDKIKNSQLYNIDAKGIFTKELD 61

Query: 68  VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127
            AL++   D AVHS KD+P E    L +  I +RE   +  +SN   S D LP  + +GT
Sbjct: 62  TALIDGSIDFAVHSFKDLPSELNDQLTITAIPQREAINEVLISNY--SWDELPENATLGT 119

Query: 128 SSLRRQ--CQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           SS+RR+  C+L  ++  +  + +RGN+ TR+ K++ GEYDA I+A+AG+ RLGL+  I+ 
Sbjct: 120 SSVRREAFCKLHGKK--IQTKPIRGNIDTRIRKVEEGEYDATIMALAGINRLGLQEHIKE 177

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
               +   P  GQGA+ +     DS   ++++ LNH ++ +    E+A+   +  GCQ P
Sbjct: 178 VFDEQYITPPAGQGALAVMTH-KDSEYNDVISKLNHEDSRIEAMTEKAILETIGVGCQWP 236

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQII----RGERRGAPQDAEQMGISLAEELL 295
           IG  +++    I +   + +P+G  +       ++  A   A+ +G  L E+ L
Sbjct: 237 IGIVSKVDGNNINIHCKLLSPEGKLLADVNKTTDKNNAINTAKVIGTKLREDTL 290


>UniRef50_D0J8N1 Porphobilinogen deaminase n=2 Tax=Blattabacterium
           RepID=D0J8N1_BLASP
          Length = 310

 Score =  153 bits (386), Expect = 8e-36,   Method: Compositional matrix adjust.
 Identities = 101/307 (32%), Positives = 154/307 (50%), Gaps = 11/307 (3%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           ++ ++RI TR SPLA+ QA  V+  L     G    L  + + GD+I + PL K    G+
Sbjct: 1   MNKIIRIGTRNSPLAISQAIEVQKVL--HRLGYCSHLFFIKSEGDLIQNIPLYKFKKVGI 58

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDSLDA 118
           F + L   LL  + D+AVHS+KDVP   P+ + L    +R    D  +   S+N+     
Sbjct: 59  FTRNLTDVLLSGKIDMAVHSLKDVPTSLPEKIVLSAYLKRGSFSDLLIYQGSSNFLLNSK 118

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178
           + A  ++ T SLRR+     R P   I  LRGN+ TRL KL N  +   I A  GL+RLG
Sbjct: 119 IEA--VIATGSLRRRAFWKNRYPHHTIVDLRGNINTRLKKLYNNSWKGAIFAKVGLERLG 176

Query: 179 LESRIRAALPP--EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236
           L + +        +  +P+ GQG + +  R D+     L   L+   T L    ER    
Sbjct: 177 LLNDLEGFNFKVLDWMIPSPGQGIIVVSTRKDNEWIHYLTKELDDRNTRLSANIERQFLK 236

Query: 237 RLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
            L GGC  PIG++A + +  I+   ++ + DG Q IR ++ G   +   +G   A+E+L 
Sbjct: 237 TLGGGCVTPIGAHAIIKNKIIYFTGILFSLDGMQKIRKKKIGTNYNV--IGYQCAKEILE 294

Query: 297 NGAREIL 303
            G ++IL
Sbjct: 295 EGGKKIL 301


>UniRef50_B5GJG2 Porphobilinogen deaminase n=3 Tax=Streptomyces RepID=B5GJG2_9ACTO
          Length = 335

 Score =  153 bits (386), Expect = 9e-36,   Method: Compositional matrix adjust.
 Identities = 114/304 (37%), Positives = 153/304 (50%), Gaps = 12/304 (3%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTP----LAKVGGKGLFV 63
           + +R S LA  Q   + ++     PG+      +   GD    TP    + +  G   F 
Sbjct: 35  VGSRGSALARAQVREMVERWEREVPGVRFVRRVITEAGDADRSTPTVAGVTRRAGVSAFS 94

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLV-TICEREDPRDAFVSNNYDSLDALPAG 122
              E AL+    D+ VH +KD+P     G  L+ T   RED RDA       +L  LP G
Sbjct: 95  SRQEAALVRREVDVVVHCLKDLPTTPAPGTALLRTPGPREDARDALCGA---TLAGLPRG 151

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           + VGT S RR  QL   RPDL +  +RGNV  RL++L     DA++LA AGL RLGL   
Sbjct: 152 ARVGTGSTRRVAQLLALRPDLEVIPVRGNVPARLARLRT--LDAVVLAAAGLHRLGLTEE 209

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
           I   L PE   PA GQGA+ I+ R + S    LLAA     T   V AER +   L GGC
Sbjct: 210 ITEYLDPEAYPPAPGQGALAIQVR-EGSGAARLLAASGDPATDTEVRAERVLLAELHGGC 268

Query: 243 QVPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
            VP+G++      G + L A V APDG + I    +G   + +++ +++AE LL  GA  
Sbjct: 269 SVPLGTWTSRPSPGTLRLHAAVTAPDGGRQITATAQGPASEPDKLALTVAERLLAGGAAR 328

Query: 302 ILAE 305
           ILAE
Sbjct: 329 ILAE 332


>UniRef50_C0W553 Porphobilinogen deaminase n=2 Tax=Actinomycetales
           RepID=C0W553_9ACTO
          Length = 402

 Score =  151 bits (381), Expect = 3e-35,   Method: Compositional matrix adjust.
 Identities = 135/377 (35%), Positives = 183/377 (48%), Gaps = 81/377 (21%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKL--MASHPG--LVVELVPMVTRGDVILDTPLAKVGGK 59
           + +R+ TR S LAL Q+  V   L   A+  G  L VELVP+ TRGDV   T L+++GG 
Sbjct: 2   STVRLGTRGSALALTQSGLVARMLEQAAALAGQELHVELVPVRTRGDVD-PTALSQLGGV 60

Query: 60  GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD-SLDA 118
           G+F   L  ALL    D+AVHS KD+P     GL +  +  REDPRD   +      L  
Sbjct: 61  GVFATALREALLAGECDLAVHSYKDLPTAAVPGLRIAAVPAREDPRDVLCTRAATLGLHD 120

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG--------------EY 164
           LPAG+ VGT S RR  QL  +RPDL I  +RGNV TRL+++                 + 
Sbjct: 121 LPAGARVGTGSPRRSAQLLAQRPDLTIVPIRGNVPTRLARVVGSVVSADGPMGATAEPDL 180

Query: 165 DAIILAVAGLKRLGLE--------------SRIR---------AALPPEIS----LPAVG 197
           DA ILA++G++RLGLE              S++          AA  P  +    LPA  
Sbjct: 181 DAAILALSGMRRLGLEDYASQPLAARCGARSQVEVQGIPDGGSAAGSPATTEPWMLPAAA 240

Query: 198 QGAVGIECRLDDSRTREL------LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAE 251
           QGA+ +E R  D  + EL      LA ++   T     AER++   L  GC  P+G+ A 
Sbjct: 241 QGALAVETR--DRVSCELPVLTVALALVDDPVTRACADAERSLMRCLAAGCAAPVGALAR 298

Query: 252 LID--GE------------------------IWLRALVGAPDGSQIIRGERRGAPQDAEQ 285
            +D  GE                        I L ALV + DG+Q+ R    G  ++AE 
Sbjct: 299 PLDVAGEPAAGRDLPTEPGTALEPGPDQAPAICLEALVASLDGTQLRRASATGTLEEAED 358

Query: 286 MGISLAEELLNNGAREI 302
           +G  +AE LL +GA +I
Sbjct: 359 LGRCVAERLLADGAAQI 375


>UniRef50_C4JRY9 Porphobilinogen deaminase n=1 Tax=Uncinocarpus reesii 1704
           RepID=C4JRY9_UNCRE
          Length = 287

 Score =  151 bits (381), Expect = 4e-35,   Method: Compositional matrix adjust.
 Identities = 107/314 (34%), Positives = 156/314 (49%), Gaps = 58/314 (18%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67
           I TR+SPLAL Q   V+  L  ++P                                   
Sbjct: 11  IGTRKSPLALVQTDLVRRALQTAYPN---------------------------------- 36

Query: 68  VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALPAGSI 124
                   D+ VH    VP + P    L  +  RE+PRD  V      + +L  LPAGS+
Sbjct: 37  -------CDLKVHG--HVPTQIPDACVLGAMMPRENPRDVLVIKKGLPWMTLAELPAGSV 87

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLKRLGLESR 182
           VGTSS+RR  QLA   P L+++ +RGN+ TRL+KLD  +G +  +I+A AGL R G E+R
Sbjct: 88  VGTSSVRRTAQLARHYPHLVVQDIRGNIDTRLAKLDAEDGPFTCLIMAAAGLLRTGHENR 147

Query: 183 IRAALPPEIS--LPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
           +   L  +    L AVGQGA+GIE R DD   ++++  +    T     AER +   +EG
Sbjct: 148 VTQYLDSKNGKMLHAVGQGALGIEVRTDDEVMKDMVNKIGDMPTTYACMAERNLLRTVEG 207

Query: 241 GCQVPIGSYAELIDGE-----IWLRALVGAPDGSQIIRGERRG---APQDAEQMGISLAE 292
           GC  P+G   E I  +     + LRA+V + DG + +  E+ G   + ++AE  G  +A 
Sbjct: 208 GCSAPLGVETEWIQDDNGKSLLRLRAIVVSVDGKEAVELEKDGDVESIEEAEAFGKQVAL 267

Query: 293 ELLNNGAREILAEV 306
           EL++ GA +IL E+
Sbjct: 268 ELIDKGAGKILEEI 281


>UniRef50_B6JII8 Porphobilinogen deaminase n=11 Tax=Bradyrhizobiaceae
           RepID=B6JII8_OLICO
          Length = 338

 Score =  150 bits (379), Expect = 6e-35,   Method: Compositional matrix adjust.
 Identities = 112/322 (34%), Positives = 161/322 (50%), Gaps = 18/322 (5%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           + D  +RI TR+S +AL Q   +  +L A+ P L VE+V   T GD      L  +GGKG
Sbjct: 9   VTDKAMRIGTRKSVMALAQTSEIARQLTAADPALDVEIVKFETTGDQDQTGKLLDLGGKG 68

Query: 61  -LFVKELEVALLENRADIAVHSMKDVP-VEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118
             FV ++  A+ E R + A+HS+KD+P  E   GL +     R+ P DA V  +  +L  
Sbjct: 69  GAFVAQIRDAVREGRLEAAMHSLKDMPGNEDTPGLVIGATLTRDPPTDALVVRHGVTLAD 128

Query: 119 L----PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY---------- 164
           L      G  +GT+++RR   +    P+  I   RG   TR+ KLDNGE           
Sbjct: 129 LRRTGGKGFKIGTNAVRRAAYVRRLFPECEIIHFRGAADTRIRKLDNGEKQRLPEGGEVG 188

Query: 165 --DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHH 222
             DA+++A AGL+R+G   RI     P+  LPAVGQG V +EC   D  T   LA ++  
Sbjct: 189 PADALVMAQAGLERVGCADRIAHCFSPDEILPAVGQGIVAVECAASDWCTLARLAQIDDP 248

Query: 223 ETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD 282
            +     AER +   L G C  PI  YA +   ++ L+A V        I   RRG    
Sbjct: 249 VSRCCAAAEREVLWVLNGHCNSPIAGYAIVEGDDVLLKAAVLDEANDHFIEVTRRGPASR 308

Query: 283 AEQMGISLAEELLNNGAREILA 304
             ++G ++A ELL  GA +++A
Sbjct: 309 PRELGRAVAFELLAKGAADVIA 330


>UniRef50_D1JID7 Porphobilinogen deaminase n=1 Tax=uncultured archaeon
           RepID=D1JID7_9ARCH
          Length = 290

 Score =  149 bits (376), Expect = 1e-34,   Method: Compositional matrix adjust.
 Identities = 97/264 (36%), Positives = 148/264 (56%), Gaps = 10/264 (3%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67
           + TR S LAL Q   V ++L  S  G+  E+  + + GDV+ D  L ++   G+FVK+L+
Sbjct: 3   VGTRGSNLALVQTKKVCERL--SELGVECEIKTVQSLGDVMTDRGLYEMPTIGVFVKKLD 60

Query: 68  VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127
           + LL+ + DIAVHSMKD+P E  + L    +  R+ P DA VS     LD +P G+++GT
Sbjct: 61  MMLLDAKIDIAVHSMKDMPSEREEELDTSAVLPRDSPYDALVSRY--RLDDMPEGAVIGT 118

Query: 128 SSLRRQCQL----AERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           SS+RR+ Q      ER   + I+ +RGNV TR++K   GEYD++ILA AG +RL L+   
Sbjct: 119 SSVRRRYQFLNYVGERGVKVTIKDIRGNVDTRIAKFRRGEYDSVILAEAGFERLKLDIEY 178

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              L  +  +P+  QG + +  R   S+  E+L  ++  ET +    E  +   + GGC 
Sbjct: 179 E-RLDRDPFVPSPRQGIIAVVAR-RGSKESEILKQIDDSETRIEAEVEEEVLKVIGGGCS 236

Query: 244 VPIGSYAELIDGEIWLRALVGAPD 267
           +P+G +A    G + L   V A D
Sbjct: 237 LPVGVHATAKGGSVELAVYVAASD 260


>UniRef50_A5K0J5 Porphobilinogen deaminase, putative n=1 Tax=Plasmodium vivax
           RepID=A5K0J5_PLAVI
          Length = 341

 Score =  148 bits (373), Expect = 3e-34,   Method: Compositional matrix adjust.
 Identities = 92/319 (28%), Positives = 147/319 (46%), Gaps = 69/319 (21%)

Query: 45  GDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDP 104
           GD ILD  +   GGKG+F KEL+  L++    I VHS+KDVP+E P+ + L    +R+  
Sbjct: 2   GDHILDKKVGLFGGKGIFTKELDEQLIKKNVHICVHSLKDVPMELPEHVQLSCFLKRDTI 61

Query: 105 RDAFVSNNYDSLDAL---------------PAGSI------------------------V 125
            DAF+S  Y +L+ +                 G+I                        +
Sbjct: 62  NDAFLSVKYATLEDMNKRKMANKVEEESDQEKGTIQQMTNQGLKRDNCEGDKCTNFIPTI 121

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR- 184
           GTSSLRR  Q+     ++ ++++RGN+ TR++KL NG+YDAII+A  GL+RL  +  +R 
Sbjct: 122 GTSSLRRSSQIKYTYKNVAVKNVRGNINTRIAKLCNGQYDAIIIAKCGLERLLTKKVVRN 181

Query: 185 -----AALPPEISL------------------------PAVGQGAVGIECRLDDSRTREL 215
                  +PPE  L                        PA+ QG + +    +D  T  +
Sbjct: 182 IIRGKGKVPPEKFLLNHNDMETNLRLLRIQQINRRTIYPALCQGIIAVTSHKNDVDTSNI 241

Query: 216 LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE 275
           L  +N  +  +    ER+   ++EG C +PIG YA+++ GEI   A++    G +     
Sbjct: 242 LKNINDEKAQIMANVERSFLYQIEGNCMMPIGGYAQIVGGEIVFNAVINDTHGREKYHVR 301

Query: 276 RRGAPQDAEQMGISLAEEL 294
             G  Q+   +    A ++
Sbjct: 302 EVGTVQNCNNIAAMAATKM 320


>UniRef50_Q4E9D5 Porphobilinogen deaminase (Fragment) n=1 Tax=Wolbachia endosymbiont
           of Drosophila ananassae RepID=Q4E9D5_9RICK
          Length = 199

 Score =  147 bits (370), Expect = 6e-34,   Method: Compositional matrix adjust.
 Identities = 81/196 (41%), Positives = 119/196 (60%), Gaps = 6/196 (3%)

Query: 100 EREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL 159
           ER  P DAF+S+ ++SL++LP  + + TS++RR+ QL   RPDL I  LRGNV TRL   
Sbjct: 4   ERLSPCDAFISHKHNSLESLPQQATIATSAIRRKVQLLNFRPDLNIVPLRGNVTTRL--- 60

Query: 160 DNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAAL 219
            N  +D IILA AGL RL     I   LPP++ L AVGQGA+ I+CR +D +  +LL  +
Sbjct: 61  QNQSFDGIILAEAGLIRLEKHHLITEVLPPKVMLSAVGQGAICIQCRRNDVKIIDLLEKI 120

Query: 220 NHHETALRVTAERAMNTRLEGGCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRG 278
           N++ + + V +ER+    + G C  P+ + AE + +  ++LR ++   DG  I   ER  
Sbjct: 121 NNNMSFIGVKSERSFMKTVNGSCFTPLAALAEYVSENMLYLRCMLA--DGKNIYFTERTS 178

Query: 279 APQDAEQMGISLAEEL 294
             +DAE+MG+    EL
Sbjct: 179 FIEDAEKMGMDAGLEL 194


>UniRef50_C3MZR8 Probable porphobilinogen deaminase n=11 Tax=Sulfolobus
           RepID=HEM3_SULIA
          Length = 293

 Score =  145 bits (366), Expect = 2e-33,   Method: Compositional matrix adjust.
 Identities = 98/294 (33%), Positives = 155/294 (52%), Gaps = 11/294 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RIA R S L+  Q   + +KL     G+  E++ + T+ D+    PL+K+G KG+F KE
Sbjct: 3   IRIAARGSKLSRIQVDMLGEKL--KKIGIEYEIIDIKTKADLFSTEPLSKLG-KGVFEKE 59

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +  A+LE +ADIAVHSMKD+  E    L +  + ER+ P D  ++    +LD L +   +
Sbjct: 60  VNEAVLEGKADIAVHSMKDILSEINPSLEIFAVLERDPPYDILIAEK--NLDKLDSNITI 117

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS+RR+  L   +P++  + +RGNV TR+ K  + EY  +ILA A LKRL +      
Sbjct: 118 GTSSIRRKNFLKYIKPEINTKDIRGNVDTRIRKYLSKEYQGLILAEASLKRLNMTMNYHR 177

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
               + + P   QG +    R  D + +E+   +NH +T     AERA+ + + GGC  P
Sbjct: 178 LNVYDFT-PEANQGIIVALGRKKDEKIKEIFKEINHKDTLDEALAERAVISLVGGGCHSP 236

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRG--ERRGAPQD-AEQMGISLAEELLN 296
           IG   +    E +   +    DG + I     + G P     ++G+ L +E+ N
Sbjct: 237 IGVLFKKEGKEFY--GIASYSDGKKKITVSISKPGDPYTIGSELGLLLKKEMKN 288


>UniRef50_UPI000038E213 porphobilinogen deaminase n=1 Tax=Ferroplasma acidarmanus fer1
           RepID=UPI000038E213
          Length = 285

 Score =  142 bits (359), Expect = 1e-32,   Method: Compositional matrix adjust.
 Identities = 91/253 (35%), Positives = 136/253 (53%), Gaps = 8/253 (3%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67
           I TR S LAL QA+ VKD L +   G  V +    + GD   + PL ++   G+FV EL 
Sbjct: 5   IGTRNSKLALIQANSVKDALESR--GYEVNIKSYTSAGDSNKNIPLYRMSSTGVFVDELN 62

Query: 68  VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127
             +L+   D+AVHS KD+P    +GL +  +  R+D RD  +S     L+ + AGS++GT
Sbjct: 63  ERVLKGEIDLAVHSAKDIPSNIQKGLEITAVTGRDDFRDVLISRT--PLEEMTAGSVIGT 120

Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAAL 187
           SS+RR  Q     P++ +  +RGN+ TR+SK    +Y  II+A+A  KR+ L+      L
Sbjct: 121 SSMRRIRQAMTVNPEITVSDIRGNIDTRISKYTEKKYTGIIIAMAAYKRMKLDIE-HFIL 179

Query: 188 PPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIG 247
             E  LPA  QG + I  +  +S    +   +N  ET   +  ER + T L  GC +P+G
Sbjct: 180 SEEQFLPAPNQGIIAIVGK-SNSPASIISGEINDRETYRDMKNERFIATSLNLGCSMPVG 238

Query: 248 SYAELIDGEIWLR 260
             ++  DG+I  R
Sbjct: 239 ILSK--DGKIKTR 249


>UniRef50_Q9Y9J0 Probable porphobilinogen deaminase n=1 Tax=Aeropyrum pernix
           RepID=HEM3_AERPE
          Length = 307

 Score =  142 bits (357), Expect = 2e-32,   Method: Compositional matrix adjust.
 Identities = 108/295 (36%), Positives = 158/295 (53%), Gaps = 10/295 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVV--ELVPMVTRGDVILDTPLAKVGGKGLFV 63
           +R+A R S L+L Q     ++L + + G+ +  E+V + + GDV  D PL  +G  G+F 
Sbjct: 3   VRVAARGSRLSLLQVEQALEEL-SRYAGVSMHWEVVRVKSAGDVWSDRPLESIGVVGVFT 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQG-LGLVTICEREDPRDAFVSNNYDS-LDALPA 121
           +E++ A+    ADIAVHS+KD+P     G L +V I  R   RDA +S      ++ L  
Sbjct: 62  REVDRAVASGAADIAVHSLKDMPTSGYGGPLKIVYIASRPSARDALISRQGPGRVEDLEP 121

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           GS +GTSS RR+       P + + +LRGN+ TRL KL  G YDAII + AGL RLG++ 
Sbjct: 122 GSTLGTSSARRRALSLHYNPRIRVENLRGNLDTRLRKLREGLYDAIIASEAGLIRLGVDV 181

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
                L P    PA GQG V +  R+  S   ++L  L+         AER +      G
Sbjct: 182 EY-TPLDPSYFPPAPGQGFVAVVARV-GSNVEKMLRDLDKPPWWHVAWAERGVLEGARAG 239

Query: 242 CQVPIGSYAELIDGEIWLRALVGA--PDGSQIIRGERRGAPQDAEQMGISLAEEL 294
           C+ P+ +YAE + G   +R    A  PDGS+       G  ++A ++G+SL EEL
Sbjct: 240 CRTPVAAYAEPL-GRSMVRVTAAALSPDGSRAYWARAEGRIEEARRIGVSLGEEL 293


>UniRef50_Q86ET2 Clone ZZD1450 mRNA sequence n=3 Tax=Schistosoma japonicum
           RepID=Q86ET2_SCHJA
          Length = 277

 Score =  137 bits (345), Expect = 4e-31,   Method: Compositional matrix adjust.
 Identities = 86/208 (41%), Positives = 112/208 (53%), Gaps = 21/208 (10%)

Query: 1   MLD----NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKV 56
           MLD    + +R+ +R+S LAL Q       L    P ++ E+V + T GD ILD PL+K+
Sbjct: 1   MLDASSQHAVRVGSRRSNLALLQTEMAISLLKVQKPHIMFEVVEIATVGDEILDVPLSKI 60

Query: 57  GGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNY 113
           G K LF KELE +LL    D+ VHS+KDVP   P GL L  +  R  P D  +    N  
Sbjct: 61  GDKSLFTKELEKSLLVGEVDLVVHSLKDVPSVLPTGLVLGCVFGRSSPEDVVLMAPHNRG 120

Query: 114 DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG----------- 162
             L  LP G+ VGTSS+RR   L  + P L   S+RGN+ TRL+KLD             
Sbjct: 121 MKLSDLPVGATVGTSSIRRVATLIRKYPHLKFISIRGNLNTRLAKLDTPSNLQKQCCTGN 180

Query: 163 ---EYDAIILAVAGLKRLGLESRIRAAL 187
               YDA+ILA AG++R+G   RI   L
Sbjct: 181 QSLSYDALILAKAGVERMGWVDRIDQVL 208


>UniRef50_Q97B26 Probable porphobilinogen deaminase n=2 Tax=Thermoplasma
           RepID=HEM3_THEVO
          Length = 297

 Score =  135 bits (340), Expect = 2e-30,   Method: Compositional matrix adjust.
 Identities = 86/242 (35%), Positives = 132/242 (54%), Gaps = 6/242 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           ++I TR S LA+ QA+ V   L A   G+  E+V   + GD+    P+  +G  G+FV++
Sbjct: 3   IKIGTRPSNLAVAQANMVASSLEA--IGIDTEIVKHRSAGDIDTKNPIYSIGKTGVFVQD 60

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L   +L    D+AVHS KD+P E    L +    +R    DA VS  YD L +LP  + V
Sbjct: 61  LNNMILRGEIDVAVHSAKDIPSEIENRLTIAATLKRGSFNDALVSK-YD-LRSLPISAKV 118

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS+RR  QL   R DL   ++RGN+ TR++K+     DAI++A A ++RLGL     +
Sbjct: 119 GTSSIRRIFQLKYARQDLKFENIRGNIETRIAKMSELGLDAIVMAEAAIQRLGLNVEY-S 177

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L     +PA  QG + +  +  +   R++L  +N   T   +  ER++  +L+ GC  P
Sbjct: 178 KLDENKFVPAPNQGIIAVVSK-KEGTVRKILEEINDENTFEEMQIERSVVQQLKLGCSTP 236

Query: 246 IG 247
           +G
Sbjct: 237 VG 238


>UniRef50_Q0RS16 Porphobilinogen deaminase 1 (PBG 1) (Hydroxymethylbilane synthase
           1) (HMBS 1) (Pre-uroporphyrinogen synthase 1) n=2
           Tax=Frankia RepID=Q0RS16_FRAAA
          Length = 402

 Score =  133 bits (335), Expect = 8e-30,   Method: Compositional matrix adjust.
 Identities = 85/195 (43%), Positives = 113/195 (57%), Gaps = 6/195 (3%)

Query: 13  SPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTP--LAKVGGKGLFVKELEVAL 70
           S LAL Q+  +  +L     G  V+LVP+VT GD    +P  ++++GG G+FV  L  AL
Sbjct: 36  SALALTQSGMIAAQLR-ERVGCAVDLVPIVTAGD---RSPAEISQIGGTGVFVSALRDAL 91

Query: 71  LENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSL 130
           L    D+AVHS+KD+P   P GL L  +  RED RD  VS +   L AL  G+ V T + 
Sbjct: 92  LAGEIDLAVHSLKDLPTATPPGLVLAAVPTREDTRDVLVSPSGRGLAALGPGARVATGAP 151

Query: 131 RRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPE 190
           RR  QL        + ++RGNV TRL K  +GE DA++LA AGL RL     +   L PE
Sbjct: 152 RRAAQLRALGLGFDVVAIRGNVDTRLKKAIDGEVDAVVLAYAGLARLDRLDAVTEILDPE 211

Query: 191 ISLPAVGQGAVGIEC 205
           + LPA GQGA+ +EC
Sbjct: 212 VMLPAPGQGALAVEC 226


>UniRef50_Q83H95 Porphobilinogen deaminase n=2 Tax=Tropheryma whipplei
           RepID=Q83H95_TROW8
          Length = 321

 Score =  131 bits (329), Expect = 3e-29,   Method: Compositional matrix adjust.
 Identities = 114/336 (33%), Positives = 159/336 (47%), Gaps = 54/336 (16%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTP--LAKVGG----K 59
           LRI TR S LA  Q   V+  +                R   +LDT   L + G      
Sbjct: 4   LRIGTRSSLLATAQTAQVQKTM----------------RDVFLLDTQQVLIQTGSVRRRD 47

Query: 60  GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119
           G FV  L  ALLE   D+AVHS+KD+P+   +G  +  +  REDP D   +    +L  L
Sbjct: 48  GSFVAALRTALLEGECDLAVHSLKDIPIAPHEGTLITAVLPREDPCDVLCARKDLTLTTL 107

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179
           P+G+ VGT+S RR+ Q+   RPDL + SLRGN+  RL  LD    DAI+L+ AGLKR+  
Sbjct: 108 PSGAKVGTASARRRAQILNFRPDLDVVSLRGNIDKRLIHLDT--LDAIVLSAAGLKRIDR 165

Query: 180 ESRIRAALPPEISLPAVGQGAVGIE-CR--LDDSRTR-ELLAALNHHETALRVTAERAMN 235
           E  I  +        A GQG++ IE CR  LDD + R  +   L++    +  TAER + 
Sbjct: 166 EDAITESFDIHDWPTAAGQGSLAIEVCRAQLDDPQNRVAVTYRLDNPMARVTTTAERGVL 225

Query: 236 TRLEGGCQVPIGSYAELI--DGEIWLRALVGAPDGS---QIIRGERR------------- 277
           + L+  C  PI  +A     D  + L A V + DG    + IR  R              
Sbjct: 226 SLLQADCFSPIAVHAVYTANDKSLRLHAKVFSRDGKIFCESIRFARLVKQLTDTNQNHTK 285

Query: 278 --------GAPQDAEQMGISLAEELLNNGAREILAE 305
                    A + A  +  ++ +ELL+  AREIL +
Sbjct: 286 NSGSDDIGNALEVAMTLAKTVVDELLSKNAREILKQ 321


>UniRef50_B6YQR9 Hydroxymethylbilane synthase/uroporphyrin-III
           C-methyltransferase/uroporphyrinogen-III synthase n=1
           Tax=Candidatus Azobacteroides pseudotrichonymphae
           genomovar. CFP2 RepID=B6YQR9_AZOPC
          Length = 682

 Score =  130 bits (328), Expect = 4e-29,   Method: Compositional matrix adjust.
 Identities = 81/223 (36%), Positives = 122/223 (54%), Gaps = 20/223 (8%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG------- 58
           LR+ +R SPL+L Q      ++ +  P +  +L+ + + GD      L  +         
Sbjct: 11  LRVISRNSPLSLLQVK----EVFSFFPNIDYQLITIESFGDKNKHVALFDISNVSSFFLE 66

Query: 59  ----KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD 114
                  F +EL+ AL+ N+ADIAVHS KD+P   P  L L  + +  D  D+ +S N  
Sbjct: 67  EESISDFFTRELDEALIYNKADIAVHSAKDLPYPLPYDLELFALFQAMDKSDSLISRNNL 126

Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174
           +L+ LP  + VGTSS +R+ +L + RPDL + S+RGN+  R++K+DNG  DA+I+A   L
Sbjct: 127 TLEQLPPRARVGTSSQKRKTELLKIRPDLEVVSIRGNIEERIAKMDNGFIDALIVATCAL 186

Query: 175 KRLGLESRIRAALPPEI-SLPAVGQGAVGIECRLDDSRTRELL 216
            RLG+E+RI   LP E  SL    QG + I  R +D   + L 
Sbjct: 187 IRLGMEARIACILPFETHSL----QGNLAIVGRKNDKNVKNLF 225


>UniRef50_B4UXX3 Porphobilinogen deaminase 2 (Fragment) n=1 Tax=Streptomyces sp. Mg1
           RepID=B4UXX3_9ACTO
          Length = 231

 Score =  130 bits (326), Expect = 9e-29,   Method: Compositional matrix adjust.
 Identities = 88/224 (39%), Positives = 119/224 (53%), Gaps = 8/224 (3%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             +R+ TR SP+AL Q     D   A +P +V+++V +V+ GD     PL+ +GGKG F 
Sbjct: 9   TTVRLGTRPSPMALEQTGRFADVFRARYPQVVLDIVEIVSEGDR-HRGPLSTIGGKGAFT 67

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLV--TICEREDPRDAFV---SNNYDSLDA 118
           +  +  LL+ R    +   KDVP    +  G+V   +  RED RDA V    +   +L  
Sbjct: 68  RNADRYLLDGRVQATIACAKDVPGPHDRSPGIVIAAVLPREDTRDALVLPTGHPVTTLAE 127

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY--DAIILAVAGLKR 176
           LP G+ VGTS+ RR   L    P L+   +RGN  +RL  LD G    D +I A+AGL+R
Sbjct: 128 LPPGTRVGTSAPRRSALLKALHPTLVQVPIRGNADSRLRALDAGRLGADVMIAALAGLRR 187

Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALN 220
           LG E R    L P + LPA G G V +E R DD  T  LLA L 
Sbjct: 188 LGHEDRASEILDPAVWLPAAGAGTVIVEHRSDDPATGWLLAPLT 231


>UniRef50_B1ZV87 Porphobilinogen deaminase n=2 Tax=Opitutaceae RepID=B1ZV87_OPITP
          Length = 284

 Score =  129 bits (325), Expect = 9e-29,   Method: Compositional matrix adjust.
 Identities = 96/248 (38%), Positives = 126/248 (50%), Gaps = 13/248 (5%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L +ATR+SPLAL Q   V   L A   G+  EL+ +VT GD   +  L + GGKGLF  E
Sbjct: 4   LILATRKSPLALRQTEMVAAHLEA-RLGVQTELLKLVTTGDRQTEWSLEQKGGKGLFTSE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           LE AL    AD+AVHS KD+P +    L +     R D RD  V         + A   +
Sbjct: 63  LENALRRGEADLAVHSTKDLPGDMAAELAVAGYLPRADARDVLVLRA-----GVAAPKSL 117

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESRIR 184
            T S RR+ Q+A+  P +    +RGNV TRL K+   G  D  +LA AGL RLG+ +   
Sbjct: 118 ATGSPRRRLQIAKLYPGVTFTEIRGNVDTRLKKIGELGVADGTVLASAGLNRLGIGNWPG 177

Query: 185 A---ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
               AL     +PAVGQGA+ ++CR  D+      A +    T   V  ERA    L  G
Sbjct: 178 VEFHALGFNDMVPAVGQGAIAVQCRAADAAR---FAPVFDAATKRAVDVERAFQAALGVG 234

Query: 242 CQVPIGSY 249
           CQ   G++
Sbjct: 235 CQTAFGAH 242


>UniRef50_Q04X38 Bifunctional porphobilinogen deaminase/uroporphyrinogen synthase
           n=4 Tax=Leptospira RepID=Q04X38_LEPBL
          Length = 542

 Score =  129 bits (323), Expect = 2e-28,   Method: Compositional matrix adjust.
 Identities = 89/278 (32%), Positives = 127/278 (45%), Gaps = 32/278 (11%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +  VL+IA+R+S LA  Q + V D L    P + +EL      GD+ L TPL K+G +G+
Sbjct: 1   MSRVLKIASRKSALAKLQTYLVLDALKKKFPNIQIELHFREASGDLDLQTPLWKMGTRGV 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F ++L   L+E + D+ +HS KD+ +E   G  +V + +R D RD  +          P+
Sbjct: 61  FTQDLTKDLVEKKVDLVIHSWKDLDLEGHSGTTIVGVLDRADQRDVLLWKKSSLSKNFPS 120

Query: 122 GSIVGTSSLRRQCQLAE----------RRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAV 171
              + TSS RR+  L +          +   LI   +RGN+ TR+ K  N + D ++LA 
Sbjct: 121 ELKIQTSSPRREYNLKKFLNNSLPSRYKNSSLIFLPVRGNIQTRIRKWRNSDSDGLVLAK 180

Query: 172 AGLKRL----------------------GLESRIRAALPPEISLPAVGQGAVGIECRLDD 209
           A L RL                       LE  I   LP  +S  A  QGA+  E R DD
Sbjct: 181 AALDRLLSEDFLNSNELEYQEIRKFLKEILEESIFQVLPLSLSPSAPAQGAIAAEVRTDD 240

Query: 210 SRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIG 247
                 + AL+  E    V  ER    R  GGC   IG
Sbjct: 241 EWALGFVRALSKPEVVSAVEEERNTLKRFGGGCHQKIG 278


>UniRef50_Q9HMY5 Probable porphobilinogen deaminase n=2 Tax=Halobacterium salinarum
           RepID=HEM3_HALSA
          Length = 396

 Score =  127 bits (318), Expect = 6e-28,   Method: Compositional matrix adjust.
 Identities = 72/159 (45%), Positives = 96/159 (60%), Gaps = 2/159 (1%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M    +R+ATR S LAL QA  V D L        VELV + T GD + D  ++ +G  G
Sbjct: 1   MSSQQIRLATRGSDLALRQAGEVVDTLEDRRHD--VELVEVETEGDRVTDALISDLGKTG 58

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
            FV+ L+  ++E   D AVHSMKDVP E P+ L +  +  RE+P D  V+ +   L+ LP
Sbjct: 59  AFVRALDQEVMEGTVDAAVHSMKDVPTEVPEDLVVAAVPHRENPADVLVTPDGTDLEDLP 118

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL 159
           AGS+VGT+SLRR  Q+   RP L +  +RGNVGTR+ KL
Sbjct: 119 AGSVVGTASLRRGAQVQAHRPGLDVEPIRGNVGTRVEKL 157



 Score = 68.6 bits (166), Expect = 2e-10,   Method: Compositional matrix adjust.
 Identities = 56/148 (37%), Positives = 79/148 (53%), Gaps = 9/148 (6%)

Query: 161 NGEYDAIILAVAGLKRLGLESRIR-AALPPEISLPAVGQGAVGIECRLDDSRTRELLAAL 219
           + EYDA+++A  GL+R GL   +    L     +PA GQGA+ +  R D      L  AL
Sbjct: 246 DTEYDALVMARVGLERTGLLHHVGIEELSTGTHVPATGQGALCVTARRDSDVVDTLRDAL 305

Query: 220 NHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRAL-VGAPDGSQIIRGERRG 278
            H  T + VTAER +   L GGC  PIG +A L+ G+    A+ V + DGS+ + GE R 
Sbjct: 306 EHVRTRVEVTAERVVLEELGGGCIAPIGVHA-LVQGDTIRTAVQVFSQDGSEQV-GETR- 362

Query: 279 APQDAEQMGIS---LAEELLNNGAREIL 303
              DAEQ       LA +L + GA +++
Sbjct: 363 -ELDAEQYATDARELAADLRDRGAADLI 389


>UniRef50_A8I2X7 Porphobilinogen deaminase n=1 Tax=Chlamydomonas reinhardtii
           RepID=A8I2X7_CHLRE
          Length = 380

 Score =  118 bits (295), Expect = 3e-25,   Method: Compositional matrix adjust.
 Identities = 91/231 (39%), Positives = 120/231 (51%), Gaps = 13/231 (5%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPG----LVVELVPMVTRGDVILDTPLAKVGGKGL 61
           L IATR S LA  Q   V+  L+A+       L +  + + +RGD      L  +G  G 
Sbjct: 63  LVIATRPSKLAKEQTRQVQQLLLAAAQLKDEQLQLSTLELASRGDTTQGVSLRSLG-SGA 121

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F +EL+ A+L   AD++VHS+KD P     GL L     R DPRD  ++    SL  L  
Sbjct: 122 FTEELDQAVLSGAADMSVHSLKDCPAALAPGLLLAACLPRADPRDVLIAPEATSLGELVP 181

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           GS VGTSS RR  Q+    P L +  LRGNV +RL ++ + +  A +LA AGLKRLG+ +
Sbjct: 182 GSRVGTSSSRRAAQIKHSFPHLQVVQLRGNVDSRLGRIRSRDIGATVLAAAGLKRLGVMN 241

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232
                            GAVG+ CR DD     LL A++H  TAL V AER
Sbjct: 242 SDEGD--------TTATGAVGVVCRADDEWVVGLLDAISHRGTALEVAAER 284


>UniRef50_Q18ES3 Hydroxymethylbilane synthase (Porphobilinogen deaminase) n=9
           Tax=Halobacteriaceae RepID=Q18ES3_HALWD
          Length = 394

 Score =  114 bits (286), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 66/157 (42%), Positives = 95/157 (60%), Gaps = 4/157 (2%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            L +ATR S LAL QA  V++ L        V+L+ + TRGD I D  + ++G  G FV+
Sbjct: 10  TLTLATRGSDLALKQATSVQEALTDER--YEVDLIEVETRGDQIQDELIHQLGKTGAFVR 67

Query: 65  ELEVALLE--NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122
            L+  +L+    AD AVHSMKD+P + P  L +  I +R  P D  ++ +   L  LP+G
Sbjct: 68  ALDKKVLDPTAEADAAVHSMKDMPTDSPDDLVVAGIPQRAPPGDLLITTDGQRLSDLPSG 127

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL 159
           + +GTSSLRRQ QL ++R D+ +  LRGN+ TR+ KL
Sbjct: 128 ATIGTSSLRRQAQLLDQRTDITVEPLRGNIDTRIEKL 164



 Score = 74.3 bits (181), Expect = 5e-12,   Method: Compositional matrix adjust.
 Identities = 51/143 (35%), Positives = 74/143 (51%), Gaps = 1/143 (0%)

Query: 163 EYDAIILAVAGLKRLGLESRIR-AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNH 221
           EYDAI+LA AGL+R GL   I    L     +PA GQGA+ I  + + + T ++  A++H
Sbjct: 235 EYDAIVLAEAGLQRSGLIHHIEYVQLDTTTFVPAPGQGAIAITTQGEANATAQIREAIDH 294

Query: 222 HETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ 281
             T +  T ER +   L GGC  PIG +A L    + + A V A DG++ + G R     
Sbjct: 295 PRTRVETTVERTVLAELGGGCIAPIGVHATLQGEYVHVAAQVFASDGTETVDGSRNLPVD 354

Query: 282 DAEQMGISLAEELLNNGAREILA 304
                    A +L + GA E++A
Sbjct: 355 AHADAAAQFANKLADRGADELIA 377


>UniRef50_Q9PK95 Probable porphobilinogen deaminase n=13 Tax=Chlamydiaceae
           RepID=HEM3_CHLMU
          Length = 242

 Score =  114 bits (285), Expect = 4e-24,   Method: Compositional matrix adjust.
 Identities = 69/196 (35%), Positives = 106/196 (54%), Gaps = 3/196 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LR+A+R+SPLA+ QAH    +L    P L  +++   T+GD+   TPL  V   G F  +
Sbjct: 21  LRLASRKSPLAVLQAHECLRRLQTFFPRLWGQVITETTQGDLDQHTPLHSVENTGFFTDD 80

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           ++  +   + D+A+HS KD+P E P+   ++ I    DPRD  V      L   P+   +
Sbjct: 81  IDFLVQSGKCDLAIHSAKDLP-EKPKA-RVIAITASIDPRDILVFQEKYLLQPFPSRLRI 138

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           G SS RR+  ++   P  +I  +RG + TRL+ LD  ++DAI++A A + RLGL      
Sbjct: 139 GCSSDRRRALISSLYPSAVITDIRGTIQTRLALLDQQKFDAIVMANAAVSRLGLRLPCTV 198

Query: 186 ALPPEISLPAVGQGAV 201
            LPP    P  G+ A+
Sbjct: 199 VLPPPYH-PFQGRLAI 213


>UniRef50_B0SF66 Bifunctional porphobilinogen deaminase/uroporphyrinogen synthase
           n=2 Tax=Leptospira biflexa serovar Patoc
           RepID=B0SF66_LEPBA
          Length = 511

 Score =  112 bits (279), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 82/278 (29%), Positives = 127/278 (45%), Gaps = 33/278 (11%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   ++I  R S L+  Q H V + L   +  L  E +   + GD  L TPL + GG+G+
Sbjct: 1   MSETIKIGGRSSLLSRIQIHTVTNALKEKNKDLNFETIFRESSGDKDLTTPLWQFGGQGI 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F K+L+  LL ++ DI +HS KD+ ++  +   L+ +  RED RD  +      ++ LP 
Sbjct: 61  FTKDLQEDLLNHKVDIVIHSYKDMDLKERKETTLIPVLPREDVRDVLLFKKNKWIN-LPN 119

Query: 122 GSIVGTSSLRRQCQLAE----------RRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAV 171
              + TSS RR+  + E             ++ I S+RGN+ TRL K  + E   I++A 
Sbjct: 120 EITILTSSPRREYHIKEFLRNYFPTPINNFEIKIESVRGNIQTRLRKYLDHESGGILVAK 179

Query: 172 AGLKRL----------------------GLESRIRAALPPEISLPAVGQGAVGIECRLDD 209
           A L R+                       +   +   LP  I   A  QGA+  E R +D
Sbjct: 180 AALDRILNFQDPDQLLPELKEIQQLIKDTMNVSLFMVLPSSIFPSAPAQGALCAEIRKED 239

Query: 210 SRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIG 247
                LL+ ++  ET L    ER + +R  GGC   IG
Sbjct: 240 KHLETLLSKISDSETNLTTNEEREILSRYGGGCHQKIG 277


>UniRef50_Q6MEK3 Putative Porphobilinogen deaminase n=2 Tax=Parachlamydiaceae
           RepID=Q6MEK3_PARUW
          Length = 233

 Score =  111 bits (277), Expect = 4e-23,   Method: Compositional matrix adjust.
 Identities = 69/215 (32%), Positives = 108/215 (50%), Gaps = 3/215 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           + +  R SPL+  Q   +   L + +P +   +    T GD+   T L  +     F KE
Sbjct: 18  ISVGARSSPLSRAQVQEILKALRSFYPSIEFTISYFDTIGDLDQKTSLRDLDKTNFFTKE 77

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           ++ A+L+ +  I +HS KD+P   P GL L+ + +  D  D  V  + ++L  LP  S +
Sbjct: 78  IDEAILQKKCQIGIHSAKDLPDPIPDGLQLICLTKGVDCSDVLVLRDGETLQTLPPHSRI 137

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
            TSS+RR+  +   R D I   LRG +  RL+ L+  + D +++A A L RLGL    R 
Sbjct: 138 ATSSIRRENIVKLLRNDFIFLDLRGTIHQRLALLEKKQADGVVVAEAALIRLGLTHLNRI 197

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALN 220
            LP        GQG + I  R DD++ + L A L+
Sbjct: 198 RLP---GTTVEGQGQLAIIARKDDAKMQTLFACLD 229


>UniRef50_UPI0001B4213A porphobilinogen deaminase n=1 Tax=Listeria monocytogenes LO28
           RepID=UPI0001B4213A
          Length = 128

 Score =  106 bits (264), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 52/122 (42%), Positives = 79/122 (64%), Gaps = 2/122 (1%)

Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246
           +PPE+ LPAVGQGA+ IECR  D + R++L +++H ET + V AER    +L GGC++PI
Sbjct: 8   IPPEVCLPAVGQGALAIECRESDQQIRDMLTSIHHEETGICVEAERVFLKKLNGGCEIPI 67

Query: 247 GSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEV 306
             +A   +  +  + LVG  DGS I+  E+ GA  +  ++G  +AE+LL+ GA  I+ E+
Sbjct: 68  AGFATRANEFVQFKGLVGNADGSIILESEQVGA--NPSEIGNKVAEDLLSEGADTIIKEL 125

Query: 307 YN 308
            N
Sbjct: 126 RN 127


>UniRef50_UPI000155526F PREDICTED: similar to hydroxymethylbilane synthase n=1
           Tax=Ornithorhynchus anatinus RepID=UPI000155526F
          Length = 218

 Score =  104 bits (260), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 56/112 (50%), Positives = 73/112 (65%), Gaps = 4/112 (3%)

Query: 76  DIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLDALPAGSIVGTSSLRR 132
           D+ VHS+KD+P   P G  +  +C+RE P DA V +      +L  LP  S+VGTSSLRR
Sbjct: 91  DLVVHSLKDLPTVLPPGFTIGAVCKRESPYDAVVFHPKHVGKTLATLPEKSVVGTSSLRR 150

Query: 133 QCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESRI 183
             QL  + P L  +S+RGN+ TRL KLD   E+ AIILA AGL+RLG +SR+
Sbjct: 151 AAQLQRKFPHLEFKSIRGNLNTRLRKLDELQEFSAIILAAAGLQRLGWQSRL 202


>UniRef50_UPI0001698669 porphobilinogen deaminase n=1 Tax=Endoriftia persephone
           'Hot96_1+Hot96_2' RepID=UPI0001698669
          Length = 136

 Score =  101 bits (252), Expect = 3e-20,   Method: Compositional matrix adjust.
 Identities = 65/137 (47%), Positives = 81/137 (59%), Gaps = 19/137 (13%)

Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231
           AGLKRLG E RI A + PE SLPA+GQGA+GIECR DD++   L+A L+H +TA  V AE
Sbjct: 8   AGLKRLGFEQRITAFIAPEQSLPAIGQGAIGIECRSDDAQVNALIAPLHHVDTAACVHAE 67

Query: 232 RAMNTRLEGG-----CQ-----VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ 281
           RAMN RL GG     C+     VP  S   +     W R+ V     ++   GE  G P 
Sbjct: 68  RAMNNRLMGGSPCADCRLRDAGVPATSGCVV----WWARSTV-----ARSCVGEAEGTPD 118

Query: 282 DAEQMGISLAEELLNNG 298
           +AE +G+ LAE LL  G
Sbjct: 119 EAESLGVGLAERLLELG 135


>UniRef50_C0EAN0 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum
           DSM 5476 RepID=C0EAN0_9CLOT
          Length = 292

 Score = 99.8 bits (247), Expect = 1e-19,   Method: Compositional matrix adjust.
 Identities = 92/291 (31%), Positives = 133/291 (45%), Gaps = 18/291 (6%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           + I   Q+ L+   A ++   L + HP L  ELVP+   G     T         L  + 
Sbjct: 15  IHIGCAQNELSRNFADHLAQCLHSYHPELTAELVPIKNTGADEEPT---------LVARR 65

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI- 124
           LE AL++ R D+AV+   D+P+E    L +V I  RED RDA V   +      P  S  
Sbjct: 66  LEQALIDCRVDLAVYHALDLPLELHPELPIVAISSREDVRDALV---FPQGKQQPDFSKP 122

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +G +S R+Q QL    PD I   + G V  +L++LD GEY A++L  A L   GL+ R+ 
Sbjct: 123 IGCTSRRQQVQLHRVFPDCITAPVGGTVAEQLARLDQGEYGALVLPAAQLGWFGLQQRVG 182

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
                E  +PA G  A+ ++ R  +     LL   +  ++   V  ER     LE     
Sbjct: 183 QLFCVEELVPAAGHAAIAVQAR--EEFDAGLLECFHSWDSWDAVFCEREFARALEEE-PG 239

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIR-GERRGAPQDAEQMGISLAEEL 294
           PI  +AE + GE        A +   I R     G  +DA ++G  LA EL
Sbjct: 240 PIAVHAE-VKGETLSVVGFYADEAEGIYRMSSMSGDRKDAGRLGFELAAEL 289


>UniRef50_Q6MHU0 Hydroxymethylbilane synthase n=1 Tax=Bdellovibrio bacteriovorus
           RepID=Q6MHU0_BDEBA
          Length = 502

 Score = 96.3 bits (238), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 80/270 (29%), Positives = 126/270 (46%), Gaps = 29/270 (10%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LRI+ R+S LA  QA+ V D L   +P + ++     + GD  L  PL K+  KG+F ++
Sbjct: 3   LRISARKSDLARLQAYMVGDALKEKNPQIEIDYRFRESLGDKNLTDPLWKIPEKGVFTED 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV--SNNYDSLDALPAGS 123
               LL +  D+ VHS KD+P E      +     R D RD  +   +++D +       
Sbjct: 63  FFGELLRDETDLVVHSWKDLPTEHKSETVIAATLPRADQRDLLLVKKSHFDKIKTSKTLK 122

Query: 124 IVGTSSLRRQCQLA----ERRP----DLIIRSLRGNVGTRLSKL-DNGEYDAIILAVAGL 174
           +  +SS RR+  L     E  P    D+   S+RGN+ TR+ KL ++ E D +I+A A  
Sbjct: 123 VF-SSSPRREYNLTGFFKEHLPFGLQDVKFESVRGNMLTRVRKLIESPETDGLIVAKAAF 181

Query: 175 KRL-------GLESRIR----------AALPPEISLPAVGQGAVGIECRLDDSRTRELLA 217
            RL        LE + +            LP  ++  A  QGA+ +E        ++LL 
Sbjct: 182 DRLFSATLPEFLEGQQQLRQYFNELNWVVLPLSVNPNAAAQGALAVEVLKSRQDLQDLLQ 241

Query: 218 ALNHHETALRVTAERAMNTRLEGGCQVPIG 247
           +++H +T      ER + +   GGC   IG
Sbjct: 242 SIHHADTFHCSQKERDVLSSFGGGCHQKIG 271


>UniRef50_Q6Q923 Predicted porphobilinogen deaminase n=2 Tax=environmental samples
           RepID=Q6Q923_9GAMM
          Length = 291

 Score = 94.7 bits (234), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 83/247 (33%), Positives = 116/247 (46%), Gaps = 15/247 (6%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            ++IA+R S LAL Q      K   S      +++ + T GD I       +  K  FV 
Sbjct: 2   TIKIASRSSKLALAQVEEFVKKFGISD----YKIIKVKTEGD-IKSANGETLFDKAHFVS 56

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           +++  LL   ADIAVHS KD P     GL L      +  +D  +   +   D   +   
Sbjct: 57  DVQKCLLNGEADIAVHSAKDTPAGETTGL-LRYFLPSQSNQDVLI---FREEDKFNSEMK 112

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GTSSLRRQ Q       + I +L GNV TRL KL  GEYD IILA AGL RL L + ++
Sbjct: 113 LGTSSLRRQLQAKHHLNAINIVNLSGNVDTRLEKLSQGEYDCIILAKAGLARLKLLNELQ 172

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSR--TRELLAALNHHETAL--RVTAERAMNTRLEG 240
             +    +  A GQG + IE   D S      LL ++   +  L   ++ ER++   +  
Sbjct: 173 YEVMDWST--ASGQGFLCIEVLNDPSADIYNFLLKSIREIDLNLGKNISTERSILEAINA 230

Query: 241 GCQVPIG 247
           GC   I 
Sbjct: 231 GCNSAIS 237


>UniRef50_C0DZX9 Putative uncharacterized protein n=1 Tax=Corynebacterium
           matruchotii ATCC 33806 RepID=C0DZX9_9CORY
          Length = 152

 Score = 93.6 bits (231), Expect = 7e-18,   Method: Compositional matrix adjust.
 Identities = 54/150 (36%), Positives = 80/150 (53%), Gaps = 1/150 (0%)

Query: 156 LSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTREL 215
           ++K+ +GE DA++LA AGL R+           P   LPA  QGA+ +ECR DD+ T   
Sbjct: 1   MAKVHDGELDAVVLAYAGLSRVHRADEATEVFDPLEFLPAPAQGALAVECRADDADTIAA 60

Query: 216 LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRG 274
           +  +   +       ER +  RLE GC  P+ +YA +  D  + L A V A DGS  +R 
Sbjct: 61  ITTIADSKAYACAHTERVVLARLEAGCTAPVAAYATVAADNIMTLHAAVIAMDGSATLRA 120

Query: 275 ERRGAPQDAEQMGISLAEELLNNGAREILA 304
              G    AE +G+++A  LL++GA  +LA
Sbjct: 121 TAAGPIDTAENLGMTVARALLDDGASSLLA 150


>UniRef50_D0RNS6 Putative porphobilinogen deaminase (Pbg)(Hydroxymethylbilane
           synthase) (Hmbs) (Pre-uroporphyrinogen synthase) n=1
           Tax=alpha proteobacterium HIMB114 RepID=D0RNS6_9RICK
          Length = 492

 Score = 88.6 bits (218), Expect = 3e-16,   Method: Compositional matrix adjust.
 Identities = 79/277 (28%), Positives = 119/277 (42%), Gaps = 28/277 (10%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L I +R S LA  Q   VK +L      + +      T+GD        K  G G+F   
Sbjct: 5   LIIGSRASFLAKIQTFIVKQELKKKIKNIKITTKYHSTKGDKNQGHMPWKNLGYGIFTTS 64

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L   L+    +  VHS KD+PV   +      +  R+DPRD  +              IV
Sbjct: 65  LTNELINKNFNCVVHSYKDLPV--LKSKTDYYVITRDDPRDVLLV---KKKCLNKKKFIV 119

Query: 126 GTSSLRRQCQLAERR-----PDLIIRSLRGNVGTRLSK-LDNGEYDAIILAVAGLKR--- 176
           GTSS RR+  + + +      D+  +++RGNV TRL K +   +YDA+ +A A + R   
Sbjct: 120 GTSSPRRKSSVKDLKDLTGIKDIKTKTIRGNVTTRLLKVISKNQYDAVFMAKAAIDRIFK 179

Query: 177 -------------LGLESRIR-AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHH 222
                        L L  + +   LP  I   A  QGA+ +E   +D +T+  L  +N  
Sbjct: 180 YGNKVDKVETKKFLNLFKKFKPFILPLSIFPTAASQGAIAVEYLKNDKKTKSTLNKINCK 239

Query: 223 ETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWL 259
           +T      ER++  +  GGC + IG   E I    +L
Sbjct: 240 KTLSICNQERSLLKKYGGGCGLDIGITIEEIKNNNFL 276


>UniRef50_A8CBG6 Porphobilinogen deaminase n=3 Tax=Toxoplasma gondii
           RepID=A8CBG6_TOXGO
          Length = 747

 Score = 88.6 bits (218), Expect = 3e-16,   Method: Compositional matrix adjust.
 Identities = 41/74 (55%), Positives = 52/74 (70%)

Query: 36  VELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGL 95
           + +VPM T GD  L  PLA+VGGKGLF KEL++ALL  + D+ VHS+KDVP E P+G  +
Sbjct: 269 LRIVPMQTTGDKELHLPLAQVGGKGLFTKELDLALLHGQVDVVVHSLKDVPTELPEGTEI 328

Query: 96  VTICEREDPRDAFV 109
                REDPRDA +
Sbjct: 329 GAYLPREDPRDALI 342



 Score = 79.0 bits (193), Expect = 2e-13,   Method: Compositional matrix adjust.
 Identities = 56/160 (35%), Positives = 75/160 (46%), Gaps = 33/160 (20%)

Query: 125 VGTSSLRRQCQLAERRP--DLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           +GT SLRRQ  L    P     +  LRGNV TR+S+++ G  DA +LA AGLKRL L S 
Sbjct: 445 IGTCSLRRQALLYALLPPSSFQLMGLRGNVQTRMSRIEKGTLDATLLAAAGLKRLNLLSA 504

Query: 183 IRAA-------------------------------LPPEISLPAVGQGAVGIECRLDDSR 211
           + A                                LP ++ +PAV QG +G++CR  D+ 
Sbjct: 505 MLAPSPSATPSPCPAPSPNETSRGTEPGGCVEAVLLPADVFVPAVCQGIIGVQCRSADTG 564

Query: 212 TRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAE 251
              LL  LN   +  +   ERA    L+G C+ PI   AE
Sbjct: 565 ILSLLRELNSPSSRGQALCERAFLRALDGSCRTPIAGIAE 604


>UniRef50_C5LJF7 Porphobilinogen deaminase, putative n=5 Tax=Perkinsus marinus ATCC
           50983 RepID=C5LJF7_9ALVE
          Length = 556

 Score = 79.3 bits (194), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 81/282 (28%), Positives = 122/282 (43%), Gaps = 40/282 (14%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           +VL I +R+S LA  Q   + D L+    G+ VE       GD  L  PL K+   G+F 
Sbjct: 8   SVLHIGSRRSDLARLQTLMIAD-LLQDEMGVKVECHYREAPGDTNLKDPLWKMPETGVFT 66

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
             L   L+    D+ VHS KD+P+    G  +V    R DPRD  +    D+++ + +  
Sbjct: 67  SFLRDGLMNGAFDLVVHSWKDLPLAEESGTTVVATLPRADPRDLLLIRR-DAIEEMTSEG 125

Query: 124 ---IVGTSSLRRQCQLAERRPDLI-------IRSLRGNVGTRLSKL-DNGEYD------- 165
              IV +SS RRQ  L      ++        R +RGN+ TR+ KL D   +D       
Sbjct: 126 GKLIVLSSSPRRQFNLTPFLESVVPGVTSVQFRDVRGNIQTRMKKLMDPTIHDESLGCRP 185

Query: 166 -AIILAVAGLKRL----------------GLESRIRAALPPEISLP-AVGQGAVGIECRL 207
             +++A A + R                 G  S  R  + P  + P A  QGA+GIE   
Sbjct: 186 HGLVVAKAAVDRFIRSTREEFKESRQLVQGYISECRCMVLPLSANPTAAAQGALGIEVST 245

Query: 208 --DDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIG 247
             +    R+++ +LN   T    + E+ +     GGC   IG
Sbjct: 246 APEKEHVRKIVRSLNDRSTFDAASKEKELLNSYGGGCHQKIG 287


>UniRef50_Q401C3 Hydroxymethylbilane synthase (Fragment) n=7 Tax=Coelomata
           RepID=Q401C3_CAPHI
          Length = 109

 Score = 79.3 bits (194), Expect = 2e-13,   Method: Compositional matrix adjust.
 Identities = 41/78 (52%), Positives = 54/78 (69%), Gaps = 1/78 (1%)

Query: 114 DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVA 172
            +L+ LP  S+VGTSSLRR  QL  + P L  R++RGN+ TRL KLD   E+ AIILA A
Sbjct: 30  KTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRNIRGNLNTRLRKLDELQEFSAIILAAA 89

Query: 173 GLKRLGLESRIRAALPPE 190
           GL+R+G ++R+   L PE
Sbjct: 90  GLQRMGWQNRVGQILHPE 107


>UniRef50_B0KCR7 Porphobilinogen deaminase n=3 Tax=Thermoanaerobacter
           RepID=B0KCR7_THEP3
          Length = 168

 Score = 75.9 bits (185), Expect = 2e-12,   Method: Compositional matrix adjust.
 Identities = 49/158 (31%), Positives = 81/158 (51%), Gaps = 7/158 (4%)

Query: 142 DLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAV 201
           D+ I  +RGNV TRL K++    D I+L+ AGL RLGLES I    PP++ +PA  QG +
Sbjct: 10  DIQIVPIRGNVRTRLKKMEELNLDGIVLSAAGLHRLGLESIITEYFPPDVVVPAPCQGIL 69

Query: 202 GIE-CRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYA----ELIDGE 256
            +E     D+  +E  + +    T    + ER +       C+ P G+YA    E  + +
Sbjct: 70  AVEIAESFDNIFQEFYSYIVDRRTFFEASVERELLKAFGVNCRQPFGAYAQYRKEKDEEK 129

Query: 257 IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
           I ++ +    D  ++++ E  G  ++ ++M   L EE 
Sbjct: 130 INIKVVYQKED--KLLKSEVTGLIEETDKMIEKLIEEF 165


>UniRef50_UPI0001742E92 Porphobilinogen deaminase n=1 Tax=candidate division TM7
           single-cell isolate TM7a RepID=UPI0001742E92
          Length = 119

 Score = 62.8 bits (151), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 33/108 (30%), Positives = 60/108 (55%), Gaps = 2/108 (1%)

Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246
              +  +PA GQG + I+CR +D++ R LL  +N  E  +   AER  +   +GGC  PI
Sbjct: 5   FDTDFFMPAPGQGILCIQCRENDNKIRHLLEIINDDEVTMMCEAEREFSKIFDGGCHTPI 64

Query: 247 GSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
           G  + +I+G+      +   +GS++++ E  G  ++ +++   LAEE+
Sbjct: 65  GC-SSVIEGDTLKLKGMFNDNGSRMLK-EVEGNKENPKEIAQKLAEEI 110


>UniRef50_Q1HRH6 Hydroxymethylbilane synthase-like protein n=1 Tax=Aedes aegypti
           RepID=Q1HRH6_AEDAE
          Length = 349

 Score = 58.9 bits (141), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 35/110 (31%), Positives = 50/110 (45%), Gaps = 15/110 (13%)

Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236
           +G E RI   + P   L AVGQGA+ +ECR +D     +L+ L H ET  ++  ER+   
Sbjct: 1   MGWEKRIDQVIEPSEILYAVGQGALAVECRSNDEYILNMLSKLCHLETQCKILVERSFLK 60

Query: 237 RLEGGCQVPIGSYAEL------------IDGEIWL---RALVGAPDGSQI 271
            L GGC  P+     L            I G +W    +  + A DG  +
Sbjct: 61  TLGGGCSAPVAVCTSLKRKHDSKSNYLNIQGAVWSLDGKTEIRADDGCSV 110


>UniRef50_B8N6H4 Putative uncharacterized protein n=1 Tax=Aspergillus flavus
          NRRL3357 RepID=B8N6H4_ASPFN
          Length = 90

 Score = 48.1 bits (113), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 30/78 (38%), Positives = 40/78 (51%)

Query: 6  LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
          LRI TR+S LA+ QA  +++ L    PG   E+  + T GD    T L   G K L+  E
Sbjct: 11 LRIGTRRSNLAMVQAEGIRNCLQKIAPGRSFEIEALRTLGDRDQLTALYNFGAKSLWTTE 70

Query: 66 LEVALLENRADIAVHSMK 83
          LE  L     D+ VH +K
Sbjct: 71 LEEKLNAGELDVIVHCLK 88


>UniRef50_UPI0000D9FBB5 PREDICTED: similar to lethal (3) 02640 CG9165-PA n=1 Tax=Macaca
           mulatta RepID=UPI0000D9FBB5
          Length = 105

 Score = 42.7 bits (99), Expect = 0.016,   Method: Compositional matrix adjust.
 Identities = 34/105 (32%), Positives = 44/105 (41%), Gaps = 17/105 (16%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            LRI +R+S LA  Q   V D+L     G  V LV M                  G+F  
Sbjct: 8   TLRIGSRRSDLARLQTLMVADRL--EEMGYKVVLVGM---------------PETGVFTT 50

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV 109
            L   LL+   D+ VHS KD+P+    G  +     R DPRD  +
Sbjct: 51  FLRQKLLDGSVDLVVHSWKDLPLAEEAGTTVAATLPRADPRDLII 95


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_B7LU53 Porphobilinogen deaminase n=87 Tax=cellular orga...   469   e-131
UniRef50_B5FN93 Porphobilinogen deaminase n=168 Tax=cellular org...   461   e-128
UniRef50_C0QU69 Porphobilinogen deaminase n=4 Tax=Bacteria RepID...   439   e-122
UniRef50_Q3ACT3 Porphobilinogen deaminase n=2 Tax=Bacteria RepID...   434   e-120
UniRef50_B5YJZ4 Porphobilinogen deaminase n=2 Tax=Bacteria RepID...   432   e-120
UniRef50_Q0I178 Porphobilinogen deaminase n=45 Tax=Bacteria RepI...   425   e-118
UniRef50_D1BNZ5 Porphobilinogen deaminase n=3 Tax=Veillonella Re...   422   e-117
UniRef50_Q8YVU6 Porphobilinogen deaminase n=50 Tax=cellular orga...   421   e-116
UniRef50_C0Q9U2 HemC n=2 Tax=Bacteria RepID=C0Q9U2_DESAH              419   e-116
UniRef50_A1AUE7 Porphobilinogen deaminase n=44 Tax=Bacteria RepI...   412   e-114
UniRef50_Q8DIE4 Porphobilinogen deaminase n=11 Tax=cellular orga...   411   e-113
UniRef50_B5EBG8 Porphobilinogen deaminase n=166 Tax=Bacteria Rep...   409   e-113
UniRef50_C9KL85 Hydroxymethylbilane synthase n=1 Tax=Mitsuokella...   409   e-113
UniRef50_A6TJD5 Porphobilinogen deaminase n=2 Tax=Firmicutes Rep...   409   e-112
UniRef50_Q65GK1 Porphobilinogen deaminase n=98 Tax=Bacillales Re...   408   e-112
UniRef50_Q31PM2 Porphobilinogen deaminase n=8 Tax=cellular organ...   400   e-110
UniRef50_Q5ZRY6 Porphobilinogen deaminase n=6 Tax=Legionella Rep...   397   e-109
UniRef50_C6HUG2 Porphobilinogen deaminase n=1 Tax=Leptospirillum...   397   e-109
UniRef50_B2A1G7 Porphobilinogen deaminase n=1 Tax=Natranaerobius...   397   e-109
UniRef50_Q2RJ26 Porphobilinogen deaminase n=5 Tax=Clostridia Rep...   396   e-109
UniRef50_Q30Y29 Porphobilinogen deaminase n=13 Tax=Bacteria RepI...   391   e-107
UniRef50_B3QWI1 Porphobilinogen deaminase n=12 Tax=Chlorobiaceae...   390   e-107
UniRef50_C9R7U0 Porphobilinogen deaminase n=1 Tax=Ammonifex dege...   390   e-107
UniRef50_P08397 Porphobilinogen deaminase n=59 Tax=Chordata RepI...   389   e-107
UniRef50_B3E2H7 Porphobilinogen deaminase n=3 Tax=Proteobacteria...   388   e-106
UniRef50_Q54P93 Porphobilinogen deaminase n=1 Tax=Dictyostelium ...   386   e-106
UniRef50_Q2LQU2 Porphobilinogen deaminase n=1 Tax=Syntrophus aci...   384   e-105
UniRef50_Q4L709 Porphobilinogen deaminase n=88 Tax=Bacillales Re...   384   e-105
UniRef50_A8PKX6 Porphobilinogen deaminase n=2 Tax=Gammaproteobac...   382   e-104
UniRef50_A7NKU8 Porphobilinogen deaminase n=5 Tax=Bacteria RepID...   380   e-104
UniRef50_A3ETN3 Porphobilinogen deaminase n=2 Tax=Leptospirillum...   380   e-104
UniRef50_Q1J288 Porphobilinogen deaminase n=5 Tax=Deinococci Rep...   380   e-104
UniRef50_A7GYU4 Porphobilinogen deaminase n=34 Tax=Campylobacter...   379   e-104
UniRef50_A6WXJ2 Porphobilinogen deaminase n=56 Tax=cellular orga...   378   e-103
UniRef50_B2S842 Porphobilinogen deaminase n=38 Tax=Rhizobiales R...   375   e-103
UniRef50_Q180R9 Porphobilinogen deaminase n=11 Tax=Bacteria RepI...   375   e-102
UniRef50_A6Q7Y4 Porphobilinogen deaminase n=7 Tax=Epsilonproteob...   375   e-102
UniRef50_B6FXV9 Putative uncharacterized protein n=1 Tax=Clostri...   373   e-102
UniRef50_D2R3S6 Porphobilinogen deaminase n=2 Tax=Planctomycetac...   373   e-102
UniRef50_Q43316 Porphobilinogen deaminase, chloroplastic n=61 Ta...   372   e-101
UniRef50_D0LUE1 Porphobilinogen deaminase n=1 Tax=Haliangium och...   371   e-101
UniRef50_A5VM67 Porphobilinogen deaminase n=9 Tax=Lactobacillus ...   371   e-101
UniRef50_O94048 Porphobilinogen deaminase n=53 Tax=Saccharomycet...   368   e-100
UniRef50_Q3YSA8 Porphobilinogen deaminase n=17 Tax=Rickettsiales...   368   e-100
UniRef50_C8WXM9 Porphobilinogen deaminase n=2 Tax=Alicyclobacill...   367   e-100
UniRef50_A8LIJ6 Porphobilinogen deaminase n=11 Tax=Alphaproteoba...   365   1e-99
UniRef50_P28789 Porphobilinogen deaminase n=18 Tax=Saccharomycet...   364   2e-99
UniRef50_A9A1A1 Probable porphobilinogen deaminase n=3 Tax=Thaum...   364   2e-99
UniRef50_C1CYD9 Porphobilinogen deaminase n=3 Tax=Deinococci Rep...   364   2e-99
UniRef50_D1CBT4 Porphobilinogen deaminase n=1 Tax=Thermobaculum ...   363   4e-99
UniRef50_Q8RFP5 Porphobilinogen deaminase n=16 Tax=Fusobacteriac...   362   1e-98
UniRef50_C3XEZ5 Porphobilinogen deaminase n=3 Tax=Campylobactera...   361   1e-98
UniRef50_Q5HBG1 Porphobilinogen deaminase n=2 Tax=Ehrlichia rumi...   361   2e-98
UniRef50_UPI00017922DC PREDICTED: similar to porphobilinogen dea...   360   3e-98
UniRef50_B0K2L4 Porphobilinogen deaminase n=7 Tax=Bacteria RepID...   360   3e-98
UniRef50_Q4HT06 Porphobilinogen deaminase n=1 Tax=Campylobacter ...   359   8e-98
UniRef50_B3T8H9 Putative Porphobilinogen deaminase, dipyromethan...   357   2e-97
UniRef50_C3WGN0 Porphobilinogen deaminase n=5 Tax=Fusobacterium ...   357   4e-97
UniRef50_C6XGK7 Porphobilinogen deaminase n=1 Tax=Candidatus Lib...   356   5e-97
UniRef50_UPI0001926E0E PREDICTED: similar to hydroxymethylbilane...   355   9e-97
UniRef50_UPI0000583C22 PREDICTED: hypothetical protein n=1 Tax=S...   355   1e-96
UniRef50_Q2S2A6 Porphobilinogen deaminase n=1 Tax=Salinibacter r...   354   2e-96
UniRef50_A6GVP0 Hydroxymethylbilane synthase n=18 Tax=Bacteroide...   353   6e-96
UniRef50_C6WZF5 Porphobilinogen deaminase n=1 Tax=Flavobacteriac...   352   7e-96
UniRef50_A8U3E9 Porphobilinogen deaminase n=1 Tax=alpha proteoba...   352   1e-95
UniRef50_C7N5L0 Porphobilinogen deaminase n=2 Tax=Slackia RepID=...   351   2e-95
UniRef50_Q11XT5 Porphobilinogen deaminase n=8 Tax=Bacteria RepID...   350   3e-95
UniRef50_A6DBT5 Porphobilinogen deaminase n=1 Tax=Caminibacter m...   350   3e-95
UniRef50_A9FDP9 Porphobilinogen deaminase n=1 Tax=Sorangium cell...   350   4e-95
UniRef50_A6GB01 Porphobilinogen deaminase n=2 Tax=Bacteria RepID...   349   8e-95
UniRef50_C4Z552 Porphobilinogen deaminase n=8 Tax=Bacteria RepID...   349   1e-94
UniRef50_C0YV01 Hydroxymethylbilane synthase n=1 Tax=Chryseobact...   347   3e-94
UniRef50_A3CL78 Porphobilinogen deaminase n=1 Tax=Streptococcus ...   346   5e-94
UniRef50_C3PNS9 Porphobilinogen deaminase n=15 Tax=Rickettsia Re...   345   9e-94
UniRef50_D0NJW2 Porphobilinogen deaminase n=2 Tax=Phytophthora i...   345   1e-93
UniRef50_B3U3W9 Hydroxymethylbilane synthetase n=1 Tax=Oxyrrhis ...   345   1e-93
UniRef50_B2W5W6 Porphobilinogen deaminase n=2 Tax=Pleosporineae ...   343   3e-93
UniRef50_UPI00006CBE06 porphobilinogen deaminase family protein ...   343   4e-93
UniRef50_Q1V167 Hydroxymethylbilane synthase n=3 Tax=Candidatus ...   343   4e-93
UniRef50_A3ZKX4 Porphobilinogen deaminase n=1 Tax=Blastopirellul...   343   5e-93
UniRef50_C4ZFT9 Porphobilinogen deaminase n=1 Tax=Eubacterium re...   342   8e-93
UniRef50_A8MDU3 Probable porphobilinogen deaminase n=2 Tax=Therm...   342   9e-93
UniRef50_A0LRF1 Porphobilinogen deaminase n=1 Tax=Acidothermus c...   341   2e-92
UniRef50_A2Q9P7 Catalytic activity: 4 porphobilinogen+H(2)O<=>hy...   341   2e-92
UniRef50_C1ZK04 Porphobilinogen deaminase n=1 Tax=Planctomyces l...   340   4e-92
UniRef50_B8MVK7 Porphobilinogen deaminase, putative n=1 Tax=Tala...   339   6e-92
UniRef50_A5CDH4 Porphobilinogen deaminase n=2 Tax=Orientia tsuts...   339   6e-92
UniRef50_Q0TQG4 Porphobilinogen deaminase n=32 Tax=Clostridium R...   339   8e-92
UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia...   338   1e-91
UniRef50_B5G8F1 Porphobilinogen deaminase n=1 Tax=Streptomyces s...   338   2e-91
UniRef50_C1AA38 Porphobilinogen deaminase n=1 Tax=Gemmatimonas a...   337   2e-91
UniRef50_Q82P95 Porphobilinogen deaminase 2 n=14 Tax=Actinomycet...   336   5e-91
UniRef50_Q8TXC8 Probable porphobilinogen deaminase n=1 Tax=Metha...   333   5e-90
UniRef50_A4QB59 Porphobilinogen deaminase n=15 Tax=Corynebacteri...   333   5e-90
UniRef50_A2BL26 Probable porphobilinogen deaminase n=2 Tax=Therm...   332   8e-90
UniRef50_D0J8N1 Porphobilinogen deaminase n=2 Tax=Blattabacteriu...   332   1e-89
UniRef50_C1F251 Hydroxymethylbilane synthase n=1 Tax=Acidobacter...   332   1e-89
UniRef50_C8WIZ2 Porphobilinogen deaminase n=2 Tax=Coriobacteriac...   332   1e-89
UniRef50_A8MGE4 Porphobilinogen deaminase n=30 Tax=cellular orga...   332   1e-89
UniRef50_C7NFP7 Hydroxymethylbilane synthase n=7 Tax=Actinomycet...   331   2e-89
UniRef50_B3DZQ6 Porphobilinogen deaminase n=1 Tax=Methylacidiphi...   330   3e-89
UniRef50_Q09899 Porphobilinogen deaminase n=2 Tax=Schizosaccharo...   330   4e-89
UniRef50_Q0BX92 Porphobilinogen deaminase n=1 Tax=Hyphomonas nep...   329   9e-89
UniRef50_A0DD68 Chromosome undetermined scaffold_46, whole genom...   328   1e-88
UniRef50_A4XK06 Porphobilinogen deaminase n=2 Tax=Clostridia Rep...   328   2e-88
UniRef50_C4QMG7 Hydroxymethylbilane synthase (Porphobilinogen de...   327   4e-88
UniRef50_Q8D2W2 HemC protein n=1 Tax=Wigglesworthia glossinidia ...   327   5e-88
UniRef50_Q7UPN0 Porphobilinogen deaminase n=1 Tax=Rhodopirellula...   326   5e-88
UniRef50_A4CHM3 Porphobilinogen deaminase n=4 Tax=Bacteroidetes ...   325   2e-87
UniRef50_Q4T5L1 Chromosome undetermined SCAF9206, whole genome s...   325   2e-87
UniRef50_Q47LA7 Porphobilinogen deaminase n=3 Tax=Actinomycetale...   324   2e-87
UniRef50_C6XKH7 Porphobilinogen deaminase n=1 Tax=Hirschia balti...   324   3e-87
UniRef50_Q9F7M2 Predicted porphobilinogen deaminase n=2 Tax=Bact...   323   4e-87
UniRef50_A3MLK5 Porphobilinogen deaminase n=155 Tax=Proteobacter...   323   4e-87
UniRef50_B2IAW6 Porphobilinogen deaminase n=4 Tax=Alphaproteobac...   323   5e-87
UniRef50_C2GGB5 Porphobilinogen deaminase n=2 Tax=Corynebacteriu...   323   5e-87
UniRef50_B8GXG1 Porphobilinogen deaminase n=8 Tax=Caulobacterace...   323   6e-87
UniRef50_A8SQW4 Putative uncharacterized protein n=1 Tax=Coproco...   323   6e-87
UniRef50_C6XST0 Porphobilinogen deaminase n=2 Tax=Pedobacter Rep...   323   7e-87
UniRef50_O29026 Probable porphobilinogen deaminase n=1 Tax=Archa...   322   1e-86
UniRef50_D1BFI8 Hydroxymethylbilane synthase n=4 Tax=Actinomycet...   322   1e-86
UniRef50_Q46CH0 Probable porphobilinogen deaminase n=7 Tax=Eurya...   322   1e-86
UniRef50_B3RTQ8 Putative uncharacterized protein n=1 Tax=Trichop...   322   2e-86
UniRef50_B0D5Q2 Predicted protein n=1 Tax=Laccaria bicolor S238N...   322   2e-86
UniRef50_B9XN63 Porphobilinogen deaminase n=1 Tax=bacterium Elli...   321   2e-86
UniRef50_A0QLI0 Porphobilinogen deaminase n=69 Tax=Actinomycetal...   321   2e-86
UniRef50_C5RMN3 Porphobilinogen deaminase n=1 Tax=Clostridium ce...   320   4e-86
UniRef50_C1TM53 Porphobilinogen deaminase n=1 Tax=Dethiosulfovib...   320   4e-86
UniRef50_D2NS36 Porphobilinogen deaminase n=2 Tax=Micrococcaceae...   320   5e-86
UniRef50_B6W7F3 Putative uncharacterized protein n=1 Tax=Anaeroc...   319   6e-86
UniRef50_D1VCA1 Porphobilinogen deaminase n=1 Tax=Frankia sp. Eu...   317   3e-85
UniRef50_UPI000174444E Hydroxymethylbilane synthase n=1 Tax=Verr...   317   3e-85
UniRef50_C6R3Y0 Hydroxymethylbilane synthase n=1 Tax=Rothia muci...   317   4e-85
UniRef50_B6JII8 Porphobilinogen deaminase n=11 Tax=Bradyrhizobia...   317   4e-85
UniRef50_C2FZW8 Porphobilinogen deaminase n=2 Tax=Sphingobacteri...   316   6e-85
UniRef50_A8AAB4 Probable porphobilinogen deaminase n=1 Tax=Ignic...   316   6e-85
UniRef50_C9M5W1 Hydroxymethylbilane synthase n=1 Tax=Jonquetella...   316   7e-85
UniRef50_Q1EPC8 Porphobilinogen deaminase, chloroplast (Hydroxym...   316   8e-85
UniRef50_Q57989 Probable porphobilinogen deaminase n=11 Tax=Meth...   315   1e-84
UniRef50_D2RH82 Porphobilinogen deaminase n=2 Tax=Archaeoglobace...   315   2e-84
UniRef50_Q2NEP4 HemC n=4 Tax=Methanobacteriaceae RepID=Q2NEP4_METST   314   3e-84
UniRef50_A4WN24 Probable porphobilinogen deaminase n=3 Tax=Therm...   313   4e-84
UniRef50_C0BZ93 Putative uncharacterized protein n=1 Tax=Clostri...   312   1e-83
UniRef50_A1DGB8 Porphobilinogen deaminase n=1 Tax=Neosartorya fi...   312   1e-83
UniRef50_C5CB88 Porphobilinogen deaminase n=5 Tax=Actinomycetale...   311   2e-83
UniRef50_D1C4S0 Porphobilinogen deaminase n=1 Tax=Sphaerobacter ...   308   2e-82
UniRef50_O26960 Probable porphobilinogen deaminase n=1 Tax=Metha...   307   2e-82
UniRef50_UPI0001BC2D4C glutamyl-tRNA reductase n=1 Tax=Brevibact...   307   3e-82
UniRef50_Q6AHF1 Porphobilinogen deaminase n=5 Tax=Actinobacteria...   304   2e-81
UniRef50_C6V4N6 Porphobilinogen deaminase n=2 Tax=Neorickettsia ...   304   2e-81
UniRef50_C9RPT6 Porphobilinogen deaminase n=1 Tax=Fibrobacter su...   303   5e-81
UniRef50_Q6L2G8 Probable porphobilinogen deaminase n=1 Tax=Picro...   303   5e-81
UniRef50_A8PWJ5 Putative uncharacterized protein n=1 Tax=Malasse...   303   7e-81
UniRef50_B2ULP1 Porphobilinogen deaminase n=1 Tax=Akkermansia mu...   302   1e-80
UniRef50_Q5KKQ0 Hydroxymethylbilane synthase, putative n=2 Tax=F...   302   2e-80
UniRef50_C7DH16 Porphobilinogen deaminase n=1 Tax=Candidatus Mic...   301   2e-80
UniRef50_B3LB83 Porphobilinogen deaminase, putative n=1 Tax=Plas...   301   2e-80
UniRef50_D1B7N1 Porphobilinogen deaminase n=1 Tax=Thermanaerovib...   299   8e-80
UniRef50_A6LKX0 Porphobilinogen deaminase n=1 Tax=Thermosipho me...   299   9e-80
UniRef50_A2SQU4 Uroporphyrin-III C-methyltransferase n=11 Tax=Eu...   298   1e-79
UniRef50_C5EV71 Pyruvate ferredoxin/flavodoxin oxidoreductase n=...   298   2e-79
UniRef50_A3VPD5 Porphobilinogen deaminase n=1 Tax=Parvularcula b...   298   2e-79
UniRef50_Q1AUK3 Porphobilinogen deaminase n=1 Tax=Rubrobacter xy...   297   4e-79
UniRef50_C3MZR8 Probable porphobilinogen deaminase n=11 Tax=Sulf...   297   4e-79
UniRef50_C7M2H5 Porphobilinogen deaminase n=1 Tax=Acidimicrobium...   296   8e-79
UniRef50_C7R376 Porphobilinogen deaminase n=1 Tax=Jonesia denitr...   295   1e-78
UniRef50_Q0ATQ1 Porphobilinogen deaminase n=3 Tax=Alphaproteobac...   294   2e-78
UniRef50_A4YD92 Probable porphobilinogen deaminase n=1 Tax=Metal...   294   3e-78
UniRef50_C4JRY9 Porphobilinogen deaminase n=1 Tax=Uncinocarpus r...   294   3e-78
UniRef50_D1JID7 Porphobilinogen deaminase n=1 Tax=uncultured arc...   291   2e-77
UniRef50_A9HK97 Porphobilinogen deaminase n=12 Tax=Acetobacterac...   291   3e-77
UniRef50_B5GJG2 Porphobilinogen deaminase n=3 Tax=Streptomyces R...   289   8e-77
UniRef50_Q2FTK7 Hydroxymethylbilane synthase n=3 Tax=Methanomicr...   289   8e-77
UniRef50_D2RNT2 Porphobilinogen deaminase n=1 Tax=Acidaminococcu...   289   8e-77
UniRef50_C0W553 Porphobilinogen deaminase n=2 Tax=Actinomycetale...   287   4e-76
UniRef50_C8WDJ7 Porphobilinogen deaminase n=3 Tax=Zymomonas mobi...   286   6e-76
UniRef50_Q4PFH9 Putative uncharacterized protein n=1 Tax=Ustilag...   286   7e-76
UniRef50_B4D5X7 Porphobilinogen deaminase n=1 Tax=Chthoniobacter...   282   1e-74
UniRef50_B5JN62 Porphobilinogen deaminase n=1 Tax=Verrucomicrobi...   280   4e-74
UniRef50_A2BFN7 Hydroxymethylbilane synthase (Fragment) n=6 Tax=...   279   8e-74
UniRef50_Q97B26 Probable porphobilinogen deaminase n=2 Tax=Therm...   278   1e-73
UniRef50_Q1GP41 Porphobilinogen deaminase n=7 Tax=Sphingomonadal...   278   2e-73
UniRef50_Q8I5V3 Porphobilinogen deaminase n=6 Tax=Plasmodium Rep...   277   3e-73
UniRef50_C5C5B3 Porphobilinogen deaminase n=6 Tax=Actinomycetale...   277   4e-73
UniRef50_Q9Y9J0 Probable porphobilinogen deaminase n=1 Tax=Aerop...   276   4e-73
UniRef50_C1XV35 Porphobilinogen deaminase n=2 Tax=Meiothermus Re...   275   1e-72
UniRef50_Q93A65 Porphobilinogen deaminase n=1 Tax=uncultured bac...   273   4e-72
UniRef50_Q0RS16 Porphobilinogen deaminase 1 (PBG 1) (Hydroxymeth...   273   5e-72
UniRef50_B0WMK9 Porphobilinogen deaminase n=1 Tax=Culex quinquef...   273   8e-72
UniRef50_Q83H95 Porphobilinogen deaminase n=2 Tax=Tropheryma whi...   268   1e-70
UniRef50_A7BMK1 Porphobilinogen deaminase n=1 Tax=Beggiatoa sp. ...   267   4e-70
UniRef50_UPI000038E213 porphobilinogen deaminase n=1 Tax=Ferropl...   265   1e-69
UniRef50_Q04X38 Bifunctional porphobilinogen deaminase/uroporphy...   261   2e-68
UniRef50_A9V9E0 Predicted protein n=1 Tax=Monosiga brevicollis R...   261   3e-68
UniRef50_UPI0001C31A39 porphobilinogen deaminase n=1 Tax=Conexib...   259   1e-67
UniRef50_A5K0J5 Porphobilinogen deaminase, putative n=1 Tax=Plas...   259   1e-67
UniRef50_B0SF66 Bifunctional porphobilinogen deaminase/uroporphy...   250   4e-65
UniRef50_C0EAN0 Putative uncharacterized protein n=1 Tax=Clostri...   250   6e-65
UniRef50_B1ZV87 Porphobilinogen deaminase n=2 Tax=Opitutaceae Re...   247   4e-64
UniRef50_Q86ET2 Clone ZZD1450 mRNA sequence n=3 Tax=Schistosoma ...   236   6e-61
UniRef50_Q4E9D5 Porphobilinogen deaminase (Fragment) n=1 Tax=Wol...   235   1e-60
UniRef50_Q6MHU0 Hydroxymethylbilane synthase n=1 Tax=Bdellovibri...   232   1e-59
UniRef50_B6YQR9 Hydroxymethylbilane synthase/uroporphyrin-III C-...   225   2e-57
UniRef50_B4UXX3 Porphobilinogen deaminase 2 (Fragment) n=1 Tax=S...   225   2e-57
UniRef50_Q6MEK3 Putative Porphobilinogen deaminase n=2 Tax=Parac...   224   3e-57
UniRef50_A8I2X7 Porphobilinogen deaminase n=1 Tax=Chlamydomonas ...   216   8e-55
UniRef50_Q6Q923 Predicted porphobilinogen deaminase n=2 Tax=envi...   209   1e-52
UniRef50_Q9PK95 Probable porphobilinogen deaminase n=13 Tax=Chla...   201   4e-50
UniRef50_D0RNS6 Putative porphobilinogen deaminase (Pbg)(Hydroxy...   198   2e-49
UniRef50_C5LJF7 Porphobilinogen deaminase, putative n=5 Tax=Perk...   196   9e-49
UniRef50_Q9HMY5 Probable porphobilinogen deaminase n=2 Tax=Halob...   192   1e-47
UniRef50_Q18ES3 Hydroxymethylbilane synthase (Porphobilinogen de...   181   4e-44
UniRef50_B0KCR7 Porphobilinogen deaminase n=3 Tax=Thermoanaeroba...   159   2e-37
UniRef50_UPI000155526F PREDICTED: similar to hydroxymethylbilane...   158   2e-37
UniRef50_C0DZX9 Putative uncharacterized protein n=1 Tax=Coryneb...   156   1e-36
UniRef50_UPI0001B4213A porphobilinogen deaminase n=1 Tax=Listeri...   144   3e-33
UniRef50_A8CBG6 Porphobilinogen deaminase n=3 Tax=Toxoplasma gon...   142   2e-32
UniRef50_UPI0001742E92 Porphobilinogen deaminase n=1 Tax=candida...   129   1e-28
UniRef50_Q1HRH6 Hydroxymethylbilane synthase-like protein n=1 Ta...   118   3e-25
UniRef50_Q401C3 Hydroxymethylbilane synthase (Fragment) n=7 Tax=...   117   6e-25
UniRef50_UPI0001698669 porphobilinogen deaminase n=1 Tax=Endorif...   112   2e-23
UniRef50_B8N6H4 Putative uncharacterized protein n=1 Tax=Aspergi...   100   6e-20

Sequences not found previously or not previously below threshold:

UniRef50_UPI0000D9FBB5 PREDICTED: similar to lethal (3) 02640 CG...    95   3e-18
UniRef50_UPI0001C35DE1 porphobilinogen deaminase n=1 Tax=Clostri...    80   1e-13
UniRef50_C5U771 Porphobilinogen deaminase n=1 Tax=Methanocaldoco...    72   3e-11
UniRef50_C5G109 Porphobilinogen deaminase n=1 Tax=Microsporum ca...    72   3e-11
UniRef50_C4Z1K5 Putative uncharacterized protein n=1 Tax=Eubacte...    64   8e-09
UniRef50_Q4EB45 Porphobilinogen deaminase n=1 Tax=Wolbachia endo...    62   2e-08
UniRef50_B5XH53 Porphobilinogen deaminase n=1 Tax=Salmo salar Re...    59   3e-07
UniRef50_C2BR76 Putative uncharacterized protein (Fragment) n=1 ...    58   4e-07
UniRef50_UPI0000D537E6 hypothetical protein P700755_22735 n=1 Ta...    45   0.002

>UniRef50_B7LU53 Porphobilinogen deaminase n=87 Tax=cellular organisms
           RepID=HEM3_ESCF3
          Length = 313

 Score =  469 bits (1207), Expect = e-131,   Method: Composition-based stats.
 Identities = 296/312 (94%), Positives = 302/312 (96%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           MLDNVLRIATRQSPLALWQAHYVKD LMA HPGL VELVPMVTRGDVILDTPLAKVGGKG
Sbjct: 1   MLDNVLRIATRQSPLALWQAHYVKDALMAKHPGLTVELVPMVTRGDVILDTPLAKVGGKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN Y SLD LP
Sbjct: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNKYASLDELP 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
           AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE
Sbjct: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
           SRIR ALPPE+SLPAVGQGAVGIECRLDD+RTRELLAALNH ETALRVTAERAMNTRLEG
Sbjct: 181 SRIRDALPPEVSLPAVGQGAVGIECRLDDTRTRELLAALNHPETALRVTAERAMNTRLEG 240

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           GCQVPIGSYAELI GEIWLRALVGAPDGSQ+IRGERRG+PQDAE+MGISLAEELLNNGAR
Sbjct: 241 GCQVPIGSYAELIGGEIWLRALVGAPDGSQMIRGERRGSPQDAEKMGISLAEELLNNGAR 300

Query: 301 EILAEVYNGDAP 312
            ILA+VYNGDAP
Sbjct: 301 AILADVYNGDAP 312


>UniRef50_B5FN93 Porphobilinogen deaminase n=168 Tax=cellular organisms
           RepID=HEM3_SALDC
          Length = 313

 Score =  461 bits (1186), Expect = e-128,   Method: Composition-based stats.
 Identities = 279/313 (89%), Positives = 294/313 (93%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           MLDNVLRIATRQSPLALWQAHYVKD LMA+HPGL VELVPMVTRGDVILDTPLAKVGGKG
Sbjct: 1   MLDNVLRIATRQSPLALWQAHYVKDALMATHPGLTVELVPMVTRGDVILDTPLAKVGGKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKELE+ALLE RADIAVHSMKDVPV FP GLGLVTICEREDPRDAFVSN Y SLD LP
Sbjct: 61  LFVKELEIALLEKRADIAVHSMKDVPVAFPDGLGLVTICEREDPRDAFVSNKYHSLDDLP 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
           AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRL KLDNG+YDAIILAVAGLKRLGLE
Sbjct: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLGKLDNGDYDAIILAVAGLKRLGLE 180

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
           SRIR ALPP++SLPAVGQGAVGIECRLDD+RT+ LLA LNH +TALRVTAERAMNTRLEG
Sbjct: 181 SRIRTALPPDVSLPAVGQGAVGIECRLDDARTQALLAPLNHSQTALRVTAERAMNTRLEG 240

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           GCQVPIGSYAE+I+GEIWLRALVGAPDGS ++RGERRG+P+ AEQMGISLAEELL NGAR
Sbjct: 241 GCQVPIGSYAEIINGEIWLRALVGAPDGSVMVRGERRGSPEQAEQMGISLAEELLENGAR 300

Query: 301 EILAEVYNGDAPA 313
            IL EVYNG+ PA
Sbjct: 301 AILTEVYNGETPA 313


>UniRef50_C0QU69 Porphobilinogen deaminase n=4 Tax=Bacteria RepID=C0QU69_PERMH
          Length = 308

 Score =  439 bits (1131), Expect = e-122,   Method: Composition-based stats.
 Identities = 171/304 (56%), Positives = 229/304 (75%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR+S LALWQA+Y+ D+L    P L VELV +VT+GD ILD PLAKVGGKGLFVKE
Sbjct: 3   IRIGTRKSKLALWQANYIADQLKKHFPDLEVELVKIVTKGDKILDVPLAKVGGKGLFVKE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E A+L N  DIAVHS+KDVP  FP+GLGLV I EREDPRDAF+S  Y+S++ +P G+++
Sbjct: 63  IEEAMLRNEIDIAVHSLKDVPTYFPEGLGLVAITEREDPRDAFLSVKYNSIEDMPEGAVL 122

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSSLRR+ Q+  +R D+ I  LRGNV TR+ KL+ G+YD IILA AGLKRLGLE ++R 
Sbjct: 123 GTSSLRRKAQIMMKRKDIRIEDLRGNVDTRIRKLEEGQYDGIILAYAGLKRLGLEGKVRQ 182

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L P+  +PAV QG +GIE RLDD +TRE+++ LNH E+ +R  AERA    LEGGCQVP
Sbjct: 183 ILQPDYMIPAVAQGFLGIEARLDDEKTREIVSVLNHRESEIRAKAERAFLKTLEGGCQVP 242

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305
           +  Y+E+++G++ +   V    G ++ R    G+ +DAE +G+ LAE+LL++GA+E+L E
Sbjct: 243 LAGYSEIVNGKLKITGFVSDLTGDRVFRDSMEGSLEDAESLGVKLAEKLLSDGAKEVLEE 302

Query: 306 VYNG 309
           +Y+G
Sbjct: 303 IYSG 306


>UniRef50_Q3ACT3 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=HEM3_CARHZ
          Length = 311

 Score =  434 bits (1116), Expect = e-120,   Method: Composition-based stats.
 Identities = 146/310 (47%), Positives = 202/310 (65%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   + + +R S LALWQ ++V ++L   HP +  ++V M T+GD ILD  LAK+G KGL
Sbjct: 1   MKKEVIVGSRDSALALWQTNWVVERLSKIHPEINFKIVTMKTKGDKILDVALAKIGDKGL 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F KELE ALL    D+AVHSMKD+P   P+GL +   CERE P D F+S        LP 
Sbjct: 61  FTKELEHALLNKTIDMAVHSMKDLPTVLPEGLKIGAFCEREYPGDVFISPKGFKFLELPQ 120

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ +GTSSLRR  Q+   RPDL    LRGN+ TR  K++  + D IILA AG+KRLG E 
Sbjct: 121 GARIGTSSLRRIAQILAVRPDLQAIPLRGNLPTRFRKMEEMDLDGIILAYAGVKRLGYED 180

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
           +I   L  ++ LPAVGQG++G+E R DD+   ELL  ++H  T   + AERA   RLEGG
Sbjct: 181 KITEMLSFDLCLPAVGQGSIGVEIRADDTFIEELLKPIDHFATNRAIRAERAFLKRLEGG 240

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           CQ+PIG+Y+E+ +  + L+ +V + DG  +I+GE+ G+ ++ E++GISLAEELL  GA++
Sbjct: 241 CQIPIGAYSEVKENRLHLKGVVASLDGKLVIKGEKEGSIEEPEKVGISLAEELLTKGAQK 300

Query: 302 ILAEVYNGDA 311
           IL E+     
Sbjct: 301 ILEEIRRDAN 310


>UniRef50_B5YJZ4 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=B5YJZ4_THEYD
          Length = 311

 Score =  432 bits (1112), Expect = e-120,   Method: Composition-based stats.
 Identities = 157/306 (51%), Positives = 218/306 (71%), Gaps = 1/306 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           N + I +R S LA+WQA++VKDKL   +P L VE+  + T GD ILD PLAK+GGKGLFV
Sbjct: 6   NKIVIGSRGSKLAMWQANWVKDKLQTLYPELKVEIEKIKTTGDKILDAPLAKIGGKGLFV 65

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KE+E ALL  R D+AVHSMKDVP E P+GL +  ICEREDPRDAF+S +   L+ LP  +
Sbjct: 66  KEIEEALLSKRVDLAVHSMKDVPTEIPEGLQISAICEREDPRDAFISKDGVLLNELPQEA 125

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           ++GTSSLRR  QL   R DL+I+ LRGNV TR+ KL +GE+ AI+LA+AG+KR+G+E+ +
Sbjct: 126 VLGTSSLRRTVQLKALRNDLVIKPLRGNVDTRIRKLKDGEFQAIVLAMAGVKRMGVENLV 185

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
             A   ++ +PA+GQGA+GIE R+DD    EL+  LNH ETA+ + AERA  + + GGCQ
Sbjct: 186 TQAFSEDLMIPAIGQGAIGIETRVDDDFVNELIKPLNHEETAICILAERAFLSVMGGGCQ 245

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQ-IIRGERRGAPQDAEQMGISLAEELLNNGAREI 302
           VP+  +A +++  + +  ++G P+G   +I+G R G+   A+ +G+ LA ELL+ G +EI
Sbjct: 246 VPLACHARIVNNSLKIVGMIGDPEGKMPVIKGFREGSLSQAQSLGVELANELLHRGGKEI 305

Query: 303 LAEVYN 308
           L +VY 
Sbjct: 306 LEKVYK 311


>UniRef50_Q0I178 Porphobilinogen deaminase n=45 Tax=Bacteria RepID=HEM3_HAES1
          Length = 321

 Score =  425 bits (1094), Expect = e-118,   Method: Composition-based stats.
 Identities = 199/318 (62%), Positives = 236/318 (74%), Gaps = 11/318 (3%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           ++  L+IATRQSPLALWQA+YVK++L   +  L VELVP++T+GDVILDTPLAK+GGKGL
Sbjct: 3   INKTLKIATRQSPLALWQANYVKNRLQQRYSHLSVELVPIITKGDVILDTPLAKIGGKGL 62

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FVKELE ALL   ADIAVHSMKDVP++FP+GL L  IC REDPRDAFVSN Y +LD LP 
Sbjct: 63  FVKELENALLNGEADIAVHSMKDVPMQFPKGLELSVICPREDPRDAFVSNKYRTLDELPQ 122

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+IVGTSSLRRQCQL   R DL IRSLRGNVGTRL+KLD G+YDAIILA AGL RLGL  
Sbjct: 123 GAIVGTSSLRRQCQLKNWRADLDIRSLRGNVGTRLNKLDQGDYDAIILASAGLIRLGLTE 182

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
           RIR+ +  +  LPA GQGAVGIECR+DD   + LL  L    T   V AERAMN  L+GG
Sbjct: 183 RIRSFIEIDTILPACGQGAVGIECRVDDRDVQSLLMPLADQTTTYCVLAERAMNFHLQGG 242

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE-----------RRGAPQDAEQMGISL 290
           CQVPIG+YA L + +++LR LVG   GSQI+  E            + A Q AE++G+S+
Sbjct: 243 CQVPIGAYAILENNQLYLRGLVGDVHGSQILSAEGQFELSLDFESSQSAVQKAEELGVSI 302

Query: 291 AEELLNNGAREILAEVYN 308
           AE+LL  GA +IL  VY 
Sbjct: 303 AEQLLQQGADKILQAVYQ 320


>UniRef50_D1BNZ5 Porphobilinogen deaminase n=3 Tax=Veillonella RepID=D1BNZ5_VEIPT
          Length = 312

 Score =  422 bits (1086), Expect = e-117,   Method: Composition-based stats.
 Identities = 144/305 (47%), Positives = 195/305 (63%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           + + +RI TR+S LALWQA ++  +L   +P + VELV   T+GD IL+ PLA+VGGKGL
Sbjct: 1   MRDHIRIGTRKSALALWQAEHISAELQRLYPNITVELVHFNTKGDRILEKPLAQVGGKGL 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F  ELE A+     DIAVHS+KD+P E P+GL L  I  RE P DA VS  Y +LD LP 
Sbjct: 61  FTAELEEAMHAGDIDIAVHSLKDMPTELPEGLTLGAISAREVPYDALVSPVYKTLDKLPQ 120

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ VGTSSLRRQ QL   RPDL +  +RGNV TRLSK++  + D +ILA AGLKRLGLE 
Sbjct: 121 GARVGTSSLRRQAQLLHVRPDLKVEVIRGNVQTRLSKIETEKLDGVILAQAGLKRLGLED 180

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
           +I      +  +PAVGQGA+ IECR DD+   ++L  +N   T   V  ER+   +L GG
Sbjct: 181 QITQVFKADEMIPAVGQGALAIECRADDTEMLDMLDPINDEATRYAVEGERSFLRQLNGG 240

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           CQVP+G +  +  G++ L+A++ + DG  +  GE  G  +  E +G +LA+ L   G + 
Sbjct: 241 CQVPMGVHGTINKGQLTLKAMIASLDGKTVYEGEISGPAKKGEILGKNLAKALYEEGGKR 300

Query: 302 ILAEV 306
           I+  +
Sbjct: 301 IVDAL 305


>UniRef50_Q8YVU6 Porphobilinogen deaminase n=50 Tax=cellular organisms
           RepID=HEM3_ANASP
          Length = 323

 Score =  421 bits (1082), Expect = e-116,   Method: Composition-based stats.
 Identities = 151/307 (49%), Positives = 199/307 (64%), Gaps = 3/307 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             +RI +R+S LAL Q ++V+++L  S P +  E+  M T+GD ILD  LAK+G KGLF 
Sbjct: 10  RTIRIGSRKSQLALVQTYWVREQLQNSFPDINFEVHTMSTQGDKILDVALAKIGDKGLFT 69

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALP 120
           KELEV ++    D AVHS+KD+P   P+GL L  I ERE+P DA V +       +D LP
Sbjct: 70  KELEVGMINEEIDFAVHSLKDLPTNLPEGLALAAITERENPADALVVHENFKDKQIDTLP 129

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
           AG+++GTSSLRR  QL  + P L  + +RGN+ TRL+KLD GEYD +ILA AGL+RLG+ 
Sbjct: 130 AGAVIGTSSLRRLAQLRNQFPHLTFKDVRGNLNTRLAKLDAGEYDGLILAAAGLQRLGMG 189

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            R+   LP EISL AVGQGA+GIECR DD+    +L A+ H ET  R  AER+    LEG
Sbjct: 190 DRVHQILPKEISLHAVGQGALGIECRADDAELITVLKAIEHPETRDRCLAERSFLRSLEG 249

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           GCQVPIG   E+   E+ L  +V + DG  +++    G   DAE +GI LAE L   GA+
Sbjct: 250 GCQVPIGVNTEINGNELILTGVVASVDGQNLVKDTVSGNASDAEAIGIRLAELLREQGAQ 309

Query: 301 EILAEVY 307
           EIL  ++
Sbjct: 310 EILNTIF 316


>UniRef50_C0Q9U2 HemC n=2 Tax=Bacteria RepID=C0Q9U2_DESAH
          Length = 325

 Score =  419 bits (1079), Expect = e-116,   Method: Composition-based stats.
 Identities = 146/307 (47%), Positives = 199/307 (64%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   ++I TR S LALWQA++VKD++    P   VE++ + T GD+I+D PL+ VGGKGL
Sbjct: 19  MKKTIKIGTRGSKLALWQANHVKDRIEDQFPETEVEIMTIKTTGDMIVDRPLSMVGGKGL 78

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FVKE+E ALLE+  D+AVHSMKD+P E P GL +  +  RE+P D  +SNN  SL  LP 
Sbjct: 79  FVKEIEKALLESTIDMAVHSMKDMPGELPPGLVIGAVPARENPFDVLISNNNLSLADLPK 138

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ +GTSSLRR  Q+   RPD+   S+RGN+ TRL KL  GE+DA +LA AGL RLG+++
Sbjct: 139 GARIGTSSLRRASQIKHARPDIETASIRGNLDTRLKKLAAGEFDATLLAAAGLIRLGMKT 198

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
            I       I +PAVGQGA+ IE R +D     +LA LNH ET   V+ ERA   RL+G 
Sbjct: 199 VITQYFDETIMIPAVGQGALCIESRQEDLDIAPVLAFLNHGETHTVVSGERAFLRRLDGS 258

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           C +P+  +  L D  + L  LV + DG  I++    G P+D ++ GI+LAE LL+ GA +
Sbjct: 259 CHIPVACFGRLEDHRVILTGLVASEDGRTILKETVAGTPEDPQKAGIALAETLLSKGADK 318

Query: 302 ILAEVYN 308
           IL  + +
Sbjct: 319 ILENLNS 325


>UniRef50_A1AUE7 Porphobilinogen deaminase n=44 Tax=Bacteria RepID=HEM3_PELPD
          Length = 310

 Score =  412 bits (1061), Expect = e-114,   Method: Composition-based stats.
 Identities = 167/308 (54%), Positives = 203/308 (65%), Gaps = 1/308 (0%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M    LRI TR S LALWQA++VK +L   +P + V L  + T GD ILD PLA+VGGKG
Sbjct: 1   MPPRQLRIGTRASQLALWQANWVKSELEKRYPAMEVTLTKIKTMGDRILDVPLAQVGGKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKE+E A+L    DIAVHSMKDVP EFP+GLGL  I EREDPRDA VS        LP
Sbjct: 61  LFVKEIEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVVSRAAR-FSHLP 119

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ VGTS+LRRQ QL   RPDL + ++RGNV TR+ KLD    DA+ILA AGLKRLGL 
Sbjct: 120 PGARVGTSALRRQAQLLHARPDLEMVTIRGNVETRIRKLDEENLDAVILAAAGLKRLGLT 179

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            R+   L  E S+PA+GQGA+GIECRL D    E +A  NH +T+  V AERA+  R +G
Sbjct: 180 QRVAEYLDVEFSIPAIGQGALGIECRLSDPVVTEAIAFFNHPDTSHAVRAERALLRRCQG 239

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           GCQVPI ++  +  GE+ L  L+ A DG + +R E  G     E +G  LA+ LL+ G R
Sbjct: 240 GCQVPIAAHGTIRGGELRLVGLIAAVDGREFVRDEISGPVDQCEHLGEELADRLLSRGGR 299

Query: 301 EILAEVYN 308
            IL EVY 
Sbjct: 300 AILEEVYQ 307


>UniRef50_Q8DIE4 Porphobilinogen deaminase n=11 Tax=cellular organisms
           RepID=HEM3_THEEB
          Length = 320

 Score =  411 bits (1057), Expect = e-113,   Method: Composition-based stats.
 Identities = 151/314 (48%), Positives = 199/314 (63%), Gaps = 3/314 (0%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
               +RI +R+S LAL Q  +V+ +L   H     E+V M T+GD ILD  LAK+G KGL
Sbjct: 5   SSRPVRIGSRKSQLALVQTEWVQAQLQTHHRDRAFEVVTMTTQGDNILDVALAKIGDKGL 64

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDA 118
           F KELE+++L    D+AVHS+KD+P + P GL L  I EREDP DA V        ++D 
Sbjct: 65  FTKELELSMLRGETDLAVHSLKDLPTQLPDGLVLAAITEREDPADALVLGAKWTGHTIDT 124

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178
           LP G+++GTSSLRR  QL    P L  + +RGN+ TRL+KLD GEYDA+ILAVAGL+RLG
Sbjct: 125 LPEGTVIGTSSLRRLAQLRHYYPHLTFKDVRGNLNTRLAKLDAGEYDALILAVAGLRRLG 184

Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
              RI   LP  +SL AVGQGA+GIECR +D+    L+  L H ET  R  AERA   +L
Sbjct: 185 FGDRISQVLPATVSLYAVGQGALGIECRAEDADILALVKTLEHPETTARCLAERAFLRQL 244

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
           EGGCQVPIG +  + +G++ L  LV + DG ++++    G    AE++G  LA +L   G
Sbjct: 245 EGGCQVPIGVHTVIENGQLTLTGLVASLDGQRLVKDSLTGDVATAEELGTRLALKLREQG 304

Query: 299 AREILAEVYNGDAP 312
           A EIL E++    P
Sbjct: 305 ASEILEEIFATVRP 318


>UniRef50_B5EBG8 Porphobilinogen deaminase n=166 Tax=Bacteria RepID=HEM3_GEOBB
          Length = 318

 Score =  409 bits (1053), Expect = e-113,   Method: Composition-based stats.
 Identities = 158/308 (51%), Positives = 204/308 (66%), Gaps = 1/308 (0%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M    LRI TR S LALWQA++VK +L   +P + V L  + T GD ILD PLA+VGGKG
Sbjct: 1   MALKELRIGTRASQLALWQANWVKSELEKRYPDMTVTLTKIKTIGDKILDVPLAQVGGKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKE+E A+L    DIAVHSMKDVP EFP+GLGL  I EREDPRDA +SN       LP
Sbjct: 61  LFVKEIEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVISN-GVKFADLP 119

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ +GTS+LRRQ QL + RPDL +  +RGNV TR+ KL     DA+ILA AGL RLG  
Sbjct: 120 QGARIGTSALRRQAQLLKVRPDLEMVIIRGNVQTRMDKLKTEGLDAVILAAAGLNRLGFA 179

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            +I   LP ++SLPA+GQGA+GIEC L +   ++ ++  N  +T+  V AERA+  R EG
Sbjct: 180 DQITEMLPTDLSLPAIGQGALGIECNLSNQDVKDAISFFNSPDTSRAVRAERALLWRCEG 239

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           GCQVPI ++ E+   ++ L   + + DG   ++G   G   D E++G+ LAE+LL+ G  
Sbjct: 240 GCQVPIAAFGEVTGDQLKLTGFIASVDGKVSVKGVVTGPADDCEKLGVKLAEQLLSEGGH 299

Query: 301 EILAEVYN 308
            ILAEVY 
Sbjct: 300 AILAEVYQ 307


>UniRef50_C9KL85 Hydroxymethylbilane synthase n=1 Tax=Mitsuokella multacida DSM
           20544 RepID=C9KL85_9FIRM
          Length = 315

 Score =  409 bits (1053), Expect = e-113,   Method: Composition-based stats.
 Identities = 162/307 (52%), Positives = 201/307 (65%), Gaps = 1/307 (0%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M ++ + I TR S LALWQA YV D L   +P L VE   M T+GD ILD PLAK+GGKG
Sbjct: 1   MKNDTIVIGTRSSKLALWQADYVADCLRKRYPELRVEKKLMTTKGDKILDAPLAKIGGKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LF KELE  +L    DIAVHS+KD+P E P+GL +  I ER DP DA VS  Y +L+ LP
Sbjct: 61  LFTKELEQDMLAGGIDIAVHSLKDMPTEVPEGLVISAITERFDPGDAVVSPKYRTLENLP 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ VGTSSLRR+ QL   RPDL I  LRGNV TRL KL+   +DAIILAVAGLKRLG  
Sbjct: 121 QGAKVGTSSLRRKAQLLHARPDLQISDLRGNVNTRLEKLEREHFDAIILAVAGLKRLGFA 180

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            RI   LP E+ LPAVGQGA+ IE R +D   R L+A LN   T     AERA   R+EG
Sbjct: 181 DRITEVLPREMVLPAVGQGALAIETRENDREVRNLIAFLNDEATVACARAERAFLARVEG 240

Query: 241 GCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
           GCQVP+G YA    +G + + A++ + DG+++ R    G+  +AE +G +LA++LL  G 
Sbjct: 241 GCQVPVGVYAVPEAEGRLHVEAVIASLDGARLYRDAAVGSAAEAESLGTALADKLLAMGG 300

Query: 300 REILAEV 306
             IL E+
Sbjct: 301 IAILHEI 307


>UniRef50_A6TJD5 Porphobilinogen deaminase n=2 Tax=Firmicutes RepID=HEM3_ALKMQ
          Length = 316

 Score =  409 bits (1051), Expect = e-112,   Method: Composition-based stats.
 Identities = 139/307 (45%), Positives = 191/307 (62%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             ++I +R S LAL QA  + + L    P    E++ + T GD ILD  L K+GGKGLFV
Sbjct: 2   RTIKIGSRASQLALVQAEIIINMLKEKFPQYTYEIIKITTLGDRILDKTLDKIGGKGLFV 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KE++ AL E + D+A+HSMKD+P E P+ L L  I +REDPRD  ++    SL+ LP G+
Sbjct: 62  KEIQKALAEEKIDLAIHSMKDMPGETPEELVLGAITKREDPRDVLITRENKSLEELPKGA 121

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           ++G+SSLRRQ Q+   R D+ +  +RGNVGTRL K++    D +ILA AGL RLGL+ +I
Sbjct: 122 VIGSSSLRRQAQVMALRGDIKVVPIRGNVGTRLGKIETESLDGVILAAAGLNRLGLKEKI 181

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
            + L  E   PAVGQGA+G E R  D    E+L A+NH ET   V AERA    LEGGC 
Sbjct: 182 SSYLEIEDFTPAVGQGALGCEARRKDIEMLEMLLAINHEETYRCVMAERAFLKLLEGGCH 241

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           VPIG+Y +    E+ +  +V + DG ++I+ +  G   D + +GI L E L+  GA+EIL
Sbjct: 242 VPIGAYGQQQGQELHMTGMVASSDGRRVIKEQVMGDIADFQALGIQLGETLIEKGAKEIL 301

Query: 304 AEVYNGD 310
             V   +
Sbjct: 302 ETVNTDN 308


>UniRef50_Q65GK1 Porphobilinogen deaminase n=98 Tax=Bacillales RepID=HEM3_BACLD
          Length = 313

 Score =  408 bits (1049), Expect = e-112,   Method: Composition-based stats.
 Identities = 143/305 (46%), Positives = 188/305 (61%), Gaps = 4/305 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           + + +R+S LA+ Q  +V  KL   +P    E+  +VT+GD ILD  L+KVGGKGLFVKE
Sbjct: 4   IIVGSRRSKLAMTQTKWVIKKLEELNPDFTFEIKEIVTKGDRILDVTLSKVGGKGLFVKE 63

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E A+L    D+AVHSMKD+P   P+GL +  I +RED RD  +S     L  L  G++V
Sbjct: 64  IEQAMLSGEIDMAVHSMKDMPSVLPEGLMVGCIPKREDARDVLISKGRQKLADLKQGAVV 123

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL-ESRIR 184
           GTSSLRR  QL + RPDL I+ +RGN+ TRL KL+  +YDAIILA AGL R+G  +  + 
Sbjct: 124 GTSSLRRSAQLLQMRPDLEIKWIRGNIDTRLKKLETEDYDAIILAAAGLSRMGWKDDVVT 183

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L PE  LPAVGQGA+ IECR  D     L + LN   T L VTAERA    +EGGCQV
Sbjct: 184 EFLDPESCLPAVGQGALAIECRGSDEELLSLFSRLNDRYTQLTVTAERAFLHAMEGGCQV 243

Query: 245 PIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           PI  +A++  DG I L  LV +PDG  + R   +G  +D E +G   A  +   GA+ ++
Sbjct: 244 PIAGFAKMDEDGVIELTGLVASPDGKTVYRETVKG--KDPEAVGRECAAVMSEKGAKALI 301

Query: 304 AEVYN 308
             V  
Sbjct: 302 DRVKQ 306


>UniRef50_Q31PM2 Porphobilinogen deaminase n=8 Tax=cellular organisms
           RepID=HEM3_SYNE7
          Length = 320

 Score =  400 bits (1029), Expect = e-110,   Method: Composition-based stats.
 Identities = 151/312 (48%), Positives = 200/312 (64%), Gaps = 3/312 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             +RI +R+S LAL Q H+V+ +L   +P    ++  M T+GD+ILD  LAK+G KGLF 
Sbjct: 7   RPIRIGSRKSQLALVQTHWVQGELQRLYPDRQFDVQTMSTQGDIILDVALAKIGDKGLFT 66

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALP 120
           KELEVA+L    D AVHS+KD+P   P+GL L  + EREDP DA V +       L+ LP
Sbjct: 67  KELEVAMLAGEVDFAVHSLKDLPTRLPEGLILGCVTEREDPADALVVHDRFKDHQLETLP 126

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+++GTSSLRR  QL    P L  + +RGN+ TRL+KLD GEYDA+ILA AGL+RL + 
Sbjct: 127 EGTVIGTSSLRRLAQLRHHYPHLQFKDVRGNLNTRLAKLDAGEYDALILAAAGLQRLSMA 186

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            RI   +P  +SL AVGQGA+GIECR +D    ELL AL H  T+ R  AERA    LEG
Sbjct: 187 DRIHQLIPAAVSLHAVGQGALGIECRAEDPEILELLKALEHEPTSQRCLAERAFLRELEG 246

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           GCQVPIG    + DG + L  +V + DG +++R +  G   D E +G++LA +L   GA+
Sbjct: 247 GCQVPIGVNTAIADGTLTLTGMVASLDGQRLLRDQVSGPTSDPEALGLALAAQLKAQGAK 306

Query: 301 EILAEVYNGDAP 312
           EIL E++    P
Sbjct: 307 EILDEIFATVRP 318


>UniRef50_Q5ZRY6 Porphobilinogen deaminase n=6 Tax=Legionella RepID=HEM3_LEGPH
          Length = 309

 Score =  397 bits (1022), Expect = e-109,   Method: Composition-based stats.
 Identities = 153/309 (49%), Positives = 205/309 (66%), Gaps = 1/309 (0%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M   ++RIATRQSPLALWQA++V++ L+   P L +EL+PM+T GD  L   L   GGKG
Sbjct: 1   MSAKIIRIATRQSPLALWQANHVREMLVKQWPNLSIELLPMITSGDRFLKDKLLSAGGKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKELE ALL+ RAD+AVHS KD+P + P GL L  IC+R++P DA +S  + SL ALP
Sbjct: 61  LFVKELEEALLDKRADLAVHSTKDMPAQLPDGLLLTAICKRDNPFDALISPQFKSLAALP 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
             +I+GTSSLRRQ QL    P+L I++LRGN+ TRLSKL++GEY AIILA AGL+R+GL 
Sbjct: 121 KNAIIGTSSLRRQSQLLAYNPNLQIKTLRGNIHTRLSKLESGEYQAIILAAAGLERMGLA 180

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
             I   +P +I LP   QGA+ IECR DD   +EL+  LN   +AL V  ER +N +L G
Sbjct: 181 HHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELVHGLNDPISALCVHTERRVNAKLGG 240

Query: 241 GCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
            C +P   Y  + + + + LRA V   DGSQ+I  E++G   +AE +     E L+  GA
Sbjct: 241 NCHIPFAVYCTITEEKLLLLRAKVLNMDGSQMIDDEQQGKIAEAEVIADRCTESLMTKGA 300

Query: 300 REILAEVYN 308
             +L+ + +
Sbjct: 301 MSLLSTIPS 309


>UniRef50_C6HUG2 Porphobilinogen deaminase n=1 Tax=Leptospirillum ferrodiazotrophum
           RepID=C6HUG2_9BACT
          Length = 321

 Score =  397 bits (1022), Expect = e-109,   Method: Composition-based stats.
 Identities = 156/305 (51%), Positives = 205/305 (67%), Gaps = 2/305 (0%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62
            + +RI TR S LALWQA +V   +     GL  EL  + T GD+IL  PL++VGGKGLF
Sbjct: 7   SSPIRIGTRGSELALWQARHVAAMIR-HTAGLESELTIIKTTGDMILSVPLSQVGGKGLF 65

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122
           VKE+E AL+    D+AVHSMKDVP   P+GL +  I  REDPRDAFVSN Y S  +LP G
Sbjct: 66  VKEIEEALIAGTIDLAVHSMKDVPAFLPEGLEIGAILSREDPRDAFVSNAYSSFSSLPPG 125

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           + +GTSSLRR  QL +RRPDL   SLRGNVGTRL KLD  + DAIILA AGL RLG   R
Sbjct: 126 ARIGTSSLRRMAQLKKRRPDLRFESLRGNVGTRLRKLDENQIDAIILAAAGLIRLGFSDR 185

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
           IR  LP E+SLPAVGQGA+G+ECR  D R R +LA ++  ET   V AER + + L+GGC
Sbjct: 186 IREYLPVELSLPAVGQGALGLECRTGDHRIRTILARMHDPETTACVLAERGVLSALDGGC 245

Query: 243 QVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           Q+PI ++A  +   +I L A +   +G+ ++     G  ++A ++G+  A++LL+ G ++
Sbjct: 246 QLPIAAHARTISPEQIELIARILDVEGTTLLEEHTSGPAKEAHRLGVEAAQKLLSRGGQK 305

Query: 302 ILAEV 306
           IL ++
Sbjct: 306 ILTDI 310


>UniRef50_B2A1G7 Porphobilinogen deaminase n=1 Tax=Natranaerobius thermophilus
           JW/NM-WN-LF RepID=HEM3_NATTJ
          Length = 311

 Score =  397 bits (1020), Expect = e-109,   Method: Composition-based stats.
 Identities = 137/309 (44%), Positives = 195/309 (63%), Gaps = 5/309 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LRI TR+S LAL Q ++V ++L   +P + +E+  + T+GD +L+  L+KVGGKGLF+KE
Sbjct: 3   LRIGTRRSQLALDQTNWVVEQLKTHYPDIEIEIKKIETKGDQLLNVSLSKVGGKGLFLKE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           ++ ALL+   D+AVHSMKD+P E  + L +  I +R DP DA +SNN  ++D LP  + +
Sbjct: 63  IQNALLQGEIDLAVHSMKDIPTETTEDLEICAITKRVDPLDALISNNDITIDELPENAKI 122

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESRIR 184
           GTSSLRR  QL   R DL I  +RGN+ TR++KL    E DA++LA AGL R G+   I 
Sbjct: 123 GTSSLRRGSQLKAYRNDLQIIPIRGNINTRMNKLQELPELDAVVLAKAGLVRSGMTDSIS 182

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             + PEI +P  GQGA+G+E R D+   +E LA L+  E+   + AERA   RL G C V
Sbjct: 183 QNISPEIIVPCPGQGALGLEIRHDNENLKEKLAVLDDSESRKAIGAERAFLNRLGGSCHV 242

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD----AEQMGISLAEELLNNGAR 300
           P+G+YAE+I  E+ L  +V + DG  +I+   +    D       +G  LAEEL+  GA 
Sbjct: 243 PVGAYAEIISNELHLTGVVASEDGQDVIKRSVQTHLSDNNKIPSTLGNDLAEELIELGAN 302

Query: 301 EILAEVYNG 309
           +IL+E+  G
Sbjct: 303 KILSELKEG 311


>UniRef50_Q2RJ26 Porphobilinogen deaminase n=5 Tax=Clostridia RepID=HEM3_MOOTA
          Length = 313

 Score =  396 bits (1019), Expect = e-109,   Method: Composition-based stats.
 Identities = 150/302 (49%), Positives = 193/302 (63%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +++ +R+S LA WQA +V   L  + PGL   LV + T+GD ILD  LA++G KGLF KE
Sbjct: 4   IKVGSRESELARWQARWVIQALEKAWPGLSCRLVTLKTKGDKILDVALARIGDKGLFTKE 63

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           LE+ALL+   D+AVHSMKD+P   P+GL +  I  REDP D  VS    +L  LP  + V
Sbjct: 64  LELALLDGAIDLAVHSMKDMPTTLPEGLVIGAIGPREDPADVLVSPEGYTLATLPIKARV 123

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSSLRR+ QLA  RPDL +  LRGNV TRL+K++     AI+LA AGLKRL     +  
Sbjct: 124 GTSSLRRKAQLAYARPDLELVDLRGNVPTRLAKMERDGLTAIVLAAAGLKRLNHGQVLGE 183

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            +P  I LPAVGQGA+G+E R  D R  EL+AA+NH  TA  V AERA    LEGGCQVP
Sbjct: 184 PIPYHICLPAVGQGAIGVEIRAGDRRVAELVAAINHPPTAAAVRAERAYLRALEGGCQVP 243

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305
           I + A + D  + L+ +V + DG +++R    G+ +D E  G  LA +LL  GA EIL E
Sbjct: 244 IAALATVEDTALVLQGMVASLDGREMLRDIASGSTRDPEAAGRELARKLLARGAGEILQE 303

Query: 306 VY 307
           V 
Sbjct: 304 VK 305


>UniRef50_Q30Y29 Porphobilinogen deaminase n=13 Tax=Bacteria RepID=HEM3_DESDG
          Length = 316

 Score =  391 bits (1006), Expect = e-107,   Method: Composition-based stats.
 Identities = 167/311 (53%), Positives = 210/311 (67%), Gaps = 3/311 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPG-LVVELVPMVTRGDVILDTPLAKVGGKGLF 62
             + IATR S LALWQA ++K+++M  +P    VEL+ + T+GD+ILD PLAKVGGKGLF
Sbjct: 2   KKIVIATRGSKLALWQAEHIKERIMQQYPDSFEVELLVLKTKGDIILDVPLAKVGGKGLF 61

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122
           VKE+E ALL+ RADIAVHSMKDVP+E PQGL L  I ERE P D+ +S  YD LDALP G
Sbjct: 62  VKEIEEALLDGRADIAVHSMKDVPMELPQGLTLGAIPEREVPTDSLLSARYDGLDALPQG 121

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           ++VGTSSLRRQ Q+   RPDL ++ LRGNV TR+ KL +GEYDAII+A +GLKRLG  + 
Sbjct: 122 AVVGTSSLRRQSQILAMRPDLEVKWLRGNVQTRIRKLMDGEYDAIIMATSGLKRLGETAP 181

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
             + L P + +PAVGQGA+G+E R D     E+LA L+H  + + V AER     L+GGC
Sbjct: 182 FHSELGPPLFMPAVGQGALGLEYRSDRQDLAEMLAFLDHRPSRICVEAERGFLFGLQGGC 241

Query: 243 QVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           QVPI  YA +  D    L  LV   DG+ +IR    G   DA   G++LA ++   GA  
Sbjct: 242 QVPIAGYAVMTGDNSFELTGLVAELDGTAVIRRTAAGTEADARDTGLTLAAQVKAAGADA 301

Query: 302 ILAEVY-NGDA 311
           IL  VY NG A
Sbjct: 302 ILQRVYENGHA 312


>UniRef50_B3QWI1 Porphobilinogen deaminase n=12 Tax=Chlorobiaceae RepID=HEM3_CHLT3
          Length = 314

 Score =  390 bits (1004), Expect = e-107,   Method: Composition-based stats.
 Identities = 144/314 (45%), Positives = 195/314 (62%), Gaps = 4/314 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   L I TR SPLALWQA ++K +L   +P L + L  + T GD ILD PLAK+G KGL
Sbjct: 1   MKKALIIGTRSSPLALWQAEFIKAELSKHYPSLDISLRHIKTTGDKILDAPLAKIGDKGL 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F +E+E  +L N  D+AVHS+KD+P E P+GL +  I ERED RD  +S    +L  LP 
Sbjct: 61  FTREIEHVMLRNEIDLAVHSLKDLPTETPEGLVITAITEREDNRDVLISKGKYTLKTLPQ 120

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+IV TSSLRR+ QL   RPDL +  +RGN+ TR  + + G+ +A++LA AG+ RL    
Sbjct: 121 GAIVATSSLRRRSQLLHLRPDLEVIDMRGNLNTRFKRFEEGDAEAMLLAFAGVHRLEFSE 180

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
            I   +  +  LPAVGQGA+GIE R+DD  TRELL  LNH ET L    ER++   LEGG
Sbjct: 181 HIAEIISFDDILPAVGQGALGIETRIDDEETRELLKVLNHAETELCTKCERSLLRTLEGG 240

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR----GAPQDAEQMGISLAEELLNN 297
           CQ+PIG++A + +G       VG+ DG + I+           ++AEQ+GI +A+     
Sbjct: 241 CQIPIGAHARIENGTFHFATYVGSIDGKRAIKKSLSRENVTTVEEAEQIGIEVADAARAA 300

Query: 298 GAREILAEVYNGDA 311
           GA EIL E+   +A
Sbjct: 301 GANEILCEIRTDNA 314


>UniRef50_C9R7U0 Porphobilinogen deaminase n=1 Tax=Ammonifex degensii KC4
           RepID=C9R7U0_AMMDK
          Length = 308

 Score =  390 bits (1003), Expect = e-107,   Method: Composition-based stats.
 Identities = 144/303 (47%), Positives = 186/303 (61%), Gaps = 1/303 (0%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
               LRI TR S LAL Q   V   L    P    E+V + T GD + +  L ++GGKGL
Sbjct: 4   SKRCLRIGTRGSDLALAQTEQVLQILRERWPHYTYEIVKIKTTGDKVRNLALPRIGGKGL 63

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F KELEVALLE + D+AVHS+KD+P E P+ L +  +  RE P D  +S     L+ LP 
Sbjct: 64  FTKELEVALLEEKIDLAVHSLKDLPTELPEELCVGAVLPREHPGDVLISLTGAGLEDLPE 123

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ +GTSSLRRQ QL   RPDL    LRGNV TRL KL+ GE +A++LA AGL+RL L+ 
Sbjct: 124 GARIGTSSLRRQAQLKAARPDLNFVPLRGNVPTRLRKLEKGECEAVVLAWAGLRRLRLDL 183

Query: 182 RIRA-ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
             R   LP ++ LPAV QGA+G+E R +D   R+++  L+   T L VTAERA    L G
Sbjct: 184 TGRMTLLPYQVCLPAVAQGAIGVEMRKEDRELRKMVEVLDDPTTRLEVTAERAFLRWLGG 243

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           GC VPI + A +   EI L  LV  P+G +I+RG+  G+    E++GI LAE LL  GA 
Sbjct: 244 GCHVPIAALARVAGAEILLEGLVADPEGKRIVRGQESGSTAYPEEVGIRLAERLLREGAE 303

Query: 301 EIL 303
           E+L
Sbjct: 304 ELL 306


>UniRef50_P08397 Porphobilinogen deaminase n=59 Tax=Chordata RepID=HEM3_HUMAN
          Length = 361

 Score =  389 bits (1001), Expect = e-107,   Method: Composition-based stats.
 Identities = 145/334 (43%), Positives = 191/334 (57%), Gaps = 33/334 (9%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
            V+R+ TR+S LA  Q   V   L AS+PGL  E++ M T GD ILDT L+K+G K LF 
Sbjct: 19  RVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFT 78

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALP 120
           KELE AL +N  D+ VHS+KD+P   P G  +  IC+RE+P DA V +      +L+ LP
Sbjct: 79  KELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLP 138

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGL 179
             S+VGTSSLRR  QL  + P L  RS+RGN+ TRL KLD   E+ AIILA AGL+R+G 
Sbjct: 139 EKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQEFSAIILATAGLQRMGW 198

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
            +R+   L PE  + AVGQGA+G+E R  D    +L+  L+  ET LR  AERA    LE
Sbjct: 199 HNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLE 258

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-----------GAPQD------ 282
           GGC VP+  +  + DG+++L   V + DGS  I+   +           G   D      
Sbjct: 259 GGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIHVPAQHEDGPEDDPQLVGI 318

Query: 283 ------------AEQMGISLAEELLNNGAREILA 304
                       A+ +GISLA  LL+ GA+ IL 
Sbjct: 319 TARNIPRGPQLAAQNLGISLANLLLSKGAKNILD 352


>UniRef50_B3E2H7 Porphobilinogen deaminase n=3 Tax=Proteobacteria RepID=HEM3_GEOLS
          Length = 312

 Score =  388 bits (998), Expect = e-106,   Method: Composition-based stats.
 Identities = 161/308 (52%), Positives = 206/308 (66%), Gaps = 1/308 (0%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M    LRI TR S LALWQA++ K +L A +PG+ VELV + T GD ILD PLA+VGGKG
Sbjct: 1   MAPKRLRIGTRASQLALWQANWTKSELEARYPGIQVELVKIKTMGDKILDVPLAQVGGKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKE+E A+L    D+AVHSMKDVP EFP+GLGLV   +REDPRDAF+S +  +   L 
Sbjct: 61  LFVKEIEEAMLRGEIDLAVHSMKDVPTEFPEGLGLVVTTKREDPRDAFIS-DKVTFSELR 119

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ +GTS+LRRQ QL + RPDL +  +RGNV TR+ KL     DA+ILA AGL RLG  
Sbjct: 120 QGARIGTSALRRQAQLLKARPDLEMVIIRGNVETRIRKLKEDNLDAVILAAAGLNRLGFT 179

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
             +   L  + S+PA+GQGA+G+ECRLDD+ T E LA LNH +TA  V AERA+  R EG
Sbjct: 180 DVVTELLDTDFSIPAIGQGALGLECRLDDNATIEALAFLNHADTAAAVAAERALLKRCEG 239

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           GCQVPI ++  +    + L   + + DG Q +R    G+  DA ++G  LA+ LL  G +
Sbjct: 240 GCQVPIAAHGTVSGDTLTLVGFIASVDGKQTVRDRISGSTADAVKLGTELADRLLAAGGK 299

Query: 301 EILAEVYN 308
            IL +VY 
Sbjct: 300 AILEDVYQ 307


>UniRef50_Q54P93 Porphobilinogen deaminase n=1 Tax=Dictyostelium discoideum
           RepID=HEM3_DICDI
          Length = 325

 Score =  386 bits (992), Expect = e-106,   Method: Composition-based stats.
 Identities = 132/316 (41%), Positives = 191/316 (60%), Gaps = 12/316 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           + I +R+S LA+ Q  +V+D++   +PG++VE+  M T GD +LD  L+K+G KGLF KE
Sbjct: 10  VIIGSRKSQLAMLQTEWVRDRIQELNPGIIVEIKTMDTTGDKVLDVSLSKIGDKGLFTKE 69

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD-----SLDALP 120
           LE  +L    D+AVHS+KD+P + P GL L  I +R +  DAF++N         L  LP
Sbjct: 70  LEDMMLNGTIDLAVHSLKDIPTKLPDGLKLGAITKRYNTSDAFIANAKKHGKNCKLSELP 129

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--DNGEYDAIILAVAGLKRLG 178
            G+++G+SSLRR  QL +  P L  + +RGN+ TR  KL  D+  YD +ILAVAGL+R+ 
Sbjct: 130 QGAMIGSSSLRRVAQLKKAYPHLQFKDIRGNLNTRFKKLEDDSNGYDGMILAVAGLERME 189

Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
           L   I   +P  ISL AVGQG++GIEC+  D   + +L  L H E+     AER+M   L
Sbjct: 190 LTDHISEIIPDSISLYAVGQGSLGIECKDGDDFIQSILNPLIHRESMYCCEAERSMLRDL 249

Query: 239 EGGCQVPIGSYAEL-----IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEE 293
           EGGC VPIG   +L      D  + + A+V   DGS+ I  +  G      Q+G S+A++
Sbjct: 250 EGGCHVPIGVVTKLHNQSQPDETLEINAIVLNLDGSKYIESKIIGPSIQYYQLGKSIAQD 309

Query: 294 LLNNGAREILAEVYNG 309
           L+N G+++IL+E    
Sbjct: 310 LINKGSKDILSEFIKK 325


>UniRef50_Q2LQU2 Porphobilinogen deaminase n=1 Tax=Syntrophus aciditrophicus SB
           RepID=HEM3_SYNAS
          Length = 306

 Score =  384 bits (988), Expect = e-105,   Method: Composition-based stats.
 Identities = 131/304 (43%), Positives = 186/304 (61%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           ++I TR S LAL Q   +  +L   +P + +E+V + T GD+  D PLAK+GGKGLF+KE
Sbjct: 1   MKIGTRGSALALTQTRQIAARLQGQYPEMHLEIVVIKTSGDIQKDVPLAKIGGKGLFIKE 60

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E ALL    D+AVHSMKD+P E P+GL +  +  REDPRD  +S      D LPAG+ +
Sbjct: 61  IEEALLAGTVDLAVHSMKDLPAELPEGLQIAAVPRREDPRDVLISGICREFDNLPAGARI 120

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GT SLRR  QL + RPDL I  LRGN+ TR+ K+     D +++A AG++R+G   ++  
Sbjct: 121 GTGSLRRSVQLRDWRPDLEIVPLRGNLDTRIRKVAQAALDGVVVAAAGIRRMGWAEKVTQ 180

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            +P E  LPAVGQG + +E R +D   +  LA L    T   VTAERA   RL GGC +P
Sbjct: 181 FIPTEKMLPAVGQGVLCLETREEDEDLKAGLAFLEDKRTRREVTAERAFLRRLGGGCTLP 240

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305
           + ++AE     + +R +VG+ +   +IR E  G+ + A  +G  LAE LL+ G R +L  
Sbjct: 241 VAAFAEQRGDVLTIRGMVGSLNERTMIRQEIYGSVEQAVDLGTELAERLLDGGGRILLEH 300

Query: 306 VYNG 309
           + +G
Sbjct: 301 LEDG 304


>UniRef50_Q4L709 Porphobilinogen deaminase n=88 Tax=Bacillales RepID=HEM3_STAHJ
          Length = 310

 Score =  384 bits (986), Expect = e-105,   Method: Composition-based stats.
 Identities = 139/310 (44%), Positives = 196/310 (63%), Gaps = 4/310 (1%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             L + +R+S LAL Q+    DKL A  P L +E+  +VT+GD I++  L+KVGGKGLFV
Sbjct: 2   RKLVVGSRRSKLALTQSQQFIDKLKAVDPTLEIEIKEIVTKGDRIVNKQLSKVGGKGLFV 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KE++  L +   D+A+HS+KDVP   P+GL L  I +RE P DA++S N+  L+ LP GS
Sbjct: 62  KEIQQELFDKEIDMAIHSLKDVPSIIPEGLTLGCIPDREVPFDAYISKNHIPLNELPDGS 121

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           I+GTSSLRR  Q+  + P+L I+ +RGN+ TRL KL+  +YDAIILA AGL+R+G    I
Sbjct: 122 IIGTSSLRRGAQILSKYPNLEIKWIRGNIDTRLKKLEIEDYDAIILAAAGLRRMGWSDDI 181

Query: 184 -RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
               L  +I LPA+GQGA+GIECR DD    ELL+ +++   A  VTAER   + ++G C
Sbjct: 182 VTTYLDKDILLPAIGQGALGIECRSDDVELLELLSKVHNQAVANCVTAERTFLSAMDGSC 241

Query: 243 QVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           QVPIG YA    +GEI    L+  PDG++       G  ++   +G +++  L   GA E
Sbjct: 242 QVPIGGYATNKENGEIEFTGLIMTPDGTKRYEHTEVG--KNPVDLGEAVSRVLKEQGAYE 299

Query: 302 ILAEVYNGDA 311
           I+ ++    A
Sbjct: 300 IIKKLNEEQA 309


>UniRef50_A8PKX6 Porphobilinogen deaminase n=2 Tax=Gammaproteobacteria
           RepID=A8PKX6_9COXI
          Length = 311

 Score =  382 bits (981), Expect = e-104,   Method: Composition-based stats.
 Identities = 152/306 (49%), Positives = 194/306 (63%), Gaps = 2/306 (0%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62
              LRIATR+SPLA WQA  +K++L    P L + L+P VT GD      L + GGKGLF
Sbjct: 4   KKFLRIATRKSPLAYWQATSIKNQLEKIFPFLKITLLPFVTEGDR-PSHSLNQWGGKGLF 62

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122
           VKELE ALL  +ADIAVHS+KD+P+   +GL L  IC+R DPRD  +S +      LP G
Sbjct: 63  VKELEAALLHGQADIAVHSLKDLPMTLEKGLVLGAICKRCDPRDVLISRSDRLFTQLPPG 122

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           S VGTSSLRRQ QL   RPDL I  LRGN+GTRL+KL  GE+DAIILA AGL RL     
Sbjct: 123 SYVGTSSLRRQSQLLALRPDLKIGVLRGNIGTRLNKLAAGEFDAIILAAAGLIRLKKTEC 182

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
           I      +  LPA GQGA+GIEC  +D  +   ++AL H  T   V AERA++  L GGC
Sbjct: 183 ISEYFEIDHFLPAPGQGALGIECHENDEESLTYISALIHPITHSCVLAERALSRELGGGC 242

Query: 243 QVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           QVP+ +YA  +  + I L+A VG+ DG+  I+ E++G   +AE++G   A++L   G  E
Sbjct: 243 QVPLAAYAASLGQDFIRLQAFVGSSDGTTQIKVEKQGPRVEAEKIGFLAAQDLRALGVEE 302

Query: 302 ILAEVY 307
           IL +  
Sbjct: 303 ILNKFK 308


>UniRef50_A7NKU8 Porphobilinogen deaminase n=5 Tax=Bacteria RepID=HEM3_ROSCS
          Length = 303

 Score =  380 bits (978), Expect = e-104,   Method: Composition-based stats.
 Identities = 152/303 (50%), Positives = 195/303 (64%), Gaps = 1/303 (0%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           + N L I TR S LAL Q H ++D L A+HPGL V +  + TRGD+ILD PL  +G KGL
Sbjct: 1   MRNSLTIGTRASKLALVQTHMIRDALQAAHPGLTVAVERITTRGDIILDRPLNAIGDKGL 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FV E+E A+   R D+AVHS KD+P   P  + L     R DPRDA V+    +L +LP 
Sbjct: 61  FVVEIEEAMRAGRVDLAVHSAKDLPSTLPPDMTLAVCPRRADPRDALVAQPGMTLASLPH 120

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ VGTSSLRR CQL   RPDL +  LRGNV TRL KL  G+YDAI+LA AGLKRLGLE 
Sbjct: 121 GARVGTSSLRRACQLRALRPDLTLLDLRGNVDTRLRKLREGQYDAIVLAAAGLKRLGLEE 180

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
            I   L P++ +PAVGQG +G+E R  D     LLA L+       +TAERA   R+ GG
Sbjct: 181 VITELLEPDVLIPAVGQGIIGVEARAGDDEVLRLLAPLDDPAARAAITAERAFLARIGGG 240

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           C+VP+G+ A L   E+ L  ++GA DG +++RG R G+  D   +G +LAEELL+ G + 
Sbjct: 241 CRVPVGALALLEGDELLLYGMIGALDG-RMVRGMRSGSASDPAGLGSALAEELLDAGGQA 299

Query: 302 ILA 304
           +LA
Sbjct: 300 LLA 302


>UniRef50_A3ETN3 Porphobilinogen deaminase n=2 Tax=Leptospirillum sp. Group II
           RepID=A3ETN3_9BACT
          Length = 314

 Score =  380 bits (978), Expect = e-104,   Method: Composition-based stats.
 Identities = 151/315 (47%), Positives = 192/315 (60%), Gaps = 5/315 (1%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           ML   L+I +R S LALWQA +V   L+ S  G++ E+V + T GD+ILD  L++VGGKG
Sbjct: 1   MLPTPLKIGSRGSELALWQARHVAS-LIESVSGVLPEIVVIKTTGDIILDRQLSEVGGKG 59

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKE+E ALL    D+AVHSMKDVP   P GL L     REDPRD F+S +Y  + +LP
Sbjct: 60  LFVKEIEEALLRKEIDLAVHSMKDVPAFLPPGLTLAATLTREDPRDVFLSPHYPDIKSLP 119

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
             + VGTSSLRR  Q+ E R DL    LRGNVGTR+ K++ G  DAIILA AGL RLG  
Sbjct: 120 QKARVGTSSLRRLAQIREIRNDLEFIPLRGNVGTRIRKMEEGVVDAIILAGAGLLRLGHA 179

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
           +R+R  + P + LPA+GQGA+G+E R DD  T  L+ +L+   T L V AER +   L G
Sbjct: 180 NRVREWISPRVLLPAIGQGALGLEIRTDDETTGTLVRSLSDESTHLSVAAERGVLQSLNG 239

Query: 241 GCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERR---GAPQDAEQMGISLAEELLN 296
           GCQVPI +YA       + L   V    G++ I            DA QMGI L   LL+
Sbjct: 240 GCQVPIAAYAVWEKNRTLSLEGRVLDISGTRRIHARETRDIVTIDDAYQMGIDLGNRLLS 299

Query: 297 NGAREILAEVYNGDA 311
           +GA EIL  +    +
Sbjct: 300 DGAEEILNSILKKSS 314


>UniRef50_Q1J288 Porphobilinogen deaminase n=5 Tax=Deinococci RepID=HEM3_DEIGD
          Length = 309

 Score =  380 bits (976), Expect = e-104,   Method: Composition-based stats.
 Identities = 130/304 (42%), Positives = 181/304 (59%), Gaps = 3/304 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILD--TPLAKVGGKGL 61
             + + TR S LAL Q  +V  +L    P     +  + T+GD        LA+ G KG 
Sbjct: 2   RTVTVGTRGSALALAQTRWVVARLKEEWPDTDFRIQTISTKGDRDRAALQSLAQKGDKGF 61

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALP 120
           +VKE+E ALL  R DIAVHS+KD+P E P+GL + +I +R D RD  +  +    L+ LP
Sbjct: 62  WVKEIEDALLAGRIDIAVHSLKDLPTEQPEGLEIASIPKRVDARDVLIGKDGMKRLEDLP 121

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
           +G+ VGTSS+RR+  L   RPDL I  LRGN+ TRL+ L   +YDAI+LA AGL R  + 
Sbjct: 122 SGARVGTSSVRRKAFLRAYRPDLQILDLRGNIDTRLAALGTPDYDAIVLAAAGLIRTEMR 181

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            RI   + P++ LPA GQGA+ +E R DD  + E++ A++ H T  RVTAER     L  
Sbjct: 182 HRIDEFIDPDLLLPAPGQGALALETRADDDLSIEVVYAIHDHATDDRVTAEREFLAGLGA 241

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           GC  P+G++A L DG + L   VGA DGSQ+IR    G P +   +G  LA ++L  GA+
Sbjct: 242 GCMAPVGAHATLKDGVLTLEGWVGALDGSQVIRATTSGDPAECADLGAELAADMLGQGAQ 301

Query: 301 EILA 304
           +++ 
Sbjct: 302 QLIE 305


>UniRef50_A7GYU4 Porphobilinogen deaminase n=34 Tax=Campylobacterales
           RepID=HEM3_CAMC5
          Length = 311

 Score =  379 bits (975), Expect = e-104,   Method: Composition-based stats.
 Identities = 160/304 (52%), Positives = 200/304 (65%), Gaps = 3/304 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
            +L+IATR+S LALWQ+ ++K +LMA H GL VELV M T+GDVILDTPLAK+GGKGLF 
Sbjct: 2   KILKIATRKSALALWQSEHIKARLMAQHAGLQVELVGMKTKGDVILDTPLAKIGGKGLFT 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KELE ++L  +  IAVHS+KDVPV F  GL L  IC RED RDA +S  Y   D LP  +
Sbjct: 62  KELEDSMLSGQTHIAVHSLKDVPVAFLDGLVLAAICSREDVRDAMISQRYVKFDDLPQSA 121

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            VGT+SLRR+ QL   RPDL I SLRGNV TRL KL  GE+DAIILA+AG+ RL L   +
Sbjct: 122 KVGTTSLRRKMQLLRMRPDLNIISLRGNVQTRLRKLKEGEFDAIILAMAGINRLNLADEV 181

Query: 184 RAALPPEI--SLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
               P +I    PA+GQGA+G+E  +DD++  E +  LN   + +    ER   T LEGG
Sbjct: 182 AHIYPFDIAQMTPAMGQGALGVEA-VDDAQILEKIKFLNDERSVIETRVERDFVTLLEGG 240

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           CQVPIG  A L   EI + A+VG PDGS++I         + E +G  LA E +  GA+E
Sbjct: 241 CQVPIGINARLASEEIEINAIVGLPDGSEVITENLTAKKSEFESVGKELAREFIARGAKE 300

Query: 302 ILAE 305
           +L  
Sbjct: 301 LLKR 304


>UniRef50_A6WXJ2 Porphobilinogen deaminase n=56 Tax=cellular organisms
           RepID=HEM3_OCHA4
          Length = 314

 Score =  378 bits (971), Expect = e-103,   Method: Composition-based stats.
 Identities = 132/306 (43%), Positives = 174/306 (56%), Gaps = 2/306 (0%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGG 58
           + +  L+I TR S LAL QA+  + +LM +H  P   +E++PM T GD I D  L+++GG
Sbjct: 6   LKNGTLKIGTRGSKLALAQAYETRRRLMEAHGLPEEAIEIIPMSTAGDRIQDRALSEIGG 65

Query: 59  KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118
           KGLF +E+E AL + R D+AVHS KD+P   P GL L    EREDPRDAF+      L  
Sbjct: 66  KGLFTEEIEQALTDGRIDLAVHSTKDMPTVLPDGLHLSVFLEREDPRDAFIGRTASRLLD 125

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178
           LP G+ VG+SSLRRQ  +   RPD+ +   RGNV TRL KL+ GE D   LA AGL+RLG
Sbjct: 126 LPQGATVGSSSLRRQALIRRLRPDIQVVIFRGNVDTRLRKLEAGEVDGTFLACAGLRRLG 185

Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
           L   I     PE   PA GQGA+GIE R+ D+R   LLA L H ET + +  ERA    L
Sbjct: 186 LGDVITDLADPESFPPAPGQGAIGIETRIGDTRIDTLLAPLAHRETGIALACERAFLAAL 245

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
           +G C+ PI   A +    +    ++  PDGS+    +  G   +A  +G   AE L    
Sbjct: 246 DGSCRTPIAGLATVNGDTVSFHGMILKPDGSEAHEIKTEGPASNAAAIGTEAAEHLRAKA 305

Query: 299 AREILA 304
             +   
Sbjct: 306 GPQFFE 311


>UniRef50_B2S842 Porphobilinogen deaminase n=38 Tax=Rhizobiales RepID=HEM3_BRUA1
          Length = 314

 Score =  375 bits (965), Expect = e-103,   Method: Composition-based stats.
 Identities = 134/299 (44%), Positives = 170/299 (56%), Gaps = 2/299 (0%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           +  L+I TR S LAL QA+  +  L  +H  P   +E++PM T GD I D PL++VGGKG
Sbjct: 8   NGTLKIGTRGSKLALAQAYLTRRLLQEAHGLPEDAIEILPMSTAGDRIQDRPLSEVGGKG 67

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LF +E+E AL + R DIAVHS KD+P   P+GL L    EREDPRDAF+  +      LP
Sbjct: 68  LFTEEIEQALKDGRIDIAVHSTKDMPTALPEGLHLSVFLEREDPRDAFIGRSARRFMDLP 127

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ VG+SSLRRQ  +   RPD+ +   RGNV TRL KLD GE D   LA AGL+RLGL 
Sbjct: 128 QGATVGSSSLRRQALIRRLRPDIEVVMYRGNVDTRLRKLDAGEVDGTFLACAGLRRLGLA 187

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
             I   L P +  PA GQGA+GIE R+ D R   LLA L H ET + +  ERA    L+G
Sbjct: 188 DVITDVLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERAFLGALDG 247

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
            C+ PI   A +    +  R ++  PDG Q       G   DA  +G   A  +     
Sbjct: 248 SCRTPIAGLATVEGDRLSFRGMILTPDGRQAHEVTAEGVVSDAAALGTDAANRVRAMAG 306


>UniRef50_Q180R9 Porphobilinogen deaminase n=11 Tax=Bacteria RepID=HEM3_CLOD6
          Length = 301

 Score =  375 bits (964), Expect = e-102,   Method: Composition-based stats.
 Identities = 111/293 (37%), Positives = 173/293 (59%), Gaps = 1/293 (0%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           + + TR S LAL Q  +V ++L   +P +  E+  + T+GD+I +  L K+G KGLFVKE
Sbjct: 3   IVVGTRGSNLALIQTEWVINELKKKYPEISFEIKIIKTKGDLIQNVSLDKIGDKGLFVKE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALPAGSI 124
           +E  LL+ + DIAVHSMKD+P     GL      +REDPRD  +    Y +LD LP G++
Sbjct: 63  IEQQLLDGKIDIAVHSMKDMPSYLANGLKFAHTPKREDPRDVLILREGYKNLDDLPHGAV 122

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GT S RR+ QL ++RPDL I  +RGNV TR+ K+ +     I+LA +G+ R  L+ +I 
Sbjct: 123 IGTGSKRRKFQLLKQRPDLNIVQVRGNVETRIRKIKDENMHGIVLAASGIIRANLQDKIS 182

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
           + LP ++ +PA  QGA+ IE R +DS    ++ +L    T +++ AER     + G C +
Sbjct: 183 SYLPVDVVIPAPAQGALAIEIRSNDSAIEGIVNSLKDENTEIQILAERGFLDGVNGSCHI 242

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           P+ +Y E+I  +I L  L G  +G +++     G      ++G+ LA+ +L  
Sbjct: 243 PMAAYCEIIQDKIHLTGLYGDSEGKKVVIKSIDGDISSPRELGLKLAKLVLKE 295


>UniRef50_A6Q7Y4 Porphobilinogen deaminase n=7 Tax=Epsilonproteobacteria
           RepID=HEM3_SULNB
          Length = 323

 Score =  375 bits (964), Expect = e-102,   Method: Composition-based stats.
 Identities = 137/319 (42%), Positives = 191/319 (59%), Gaps = 10/319 (3%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             L IATR S LALWQA+++K+++  + P + VEL  + ++GD ILD PLA VGGKG F 
Sbjct: 2   EKLVIATRASNLALWQAYHIKERIETAFPEVRVELNEITSKGDKILDKPLALVGGKGHFT 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KELE  ++   A +AVHS+KDVP   P+GL L  I ER+D  D F+S+ Y SL  LP G+
Sbjct: 62  KELEDEMIAGNAHLAVHSLKDVPTYIPEGLELCAITERQDQSDVFLSHTYKSLSELPEGA 121

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           +VGT+SLRR+ QL E+RPDL ++ LRGNV TRL KL  G+YDAIILA  GL RL L   I
Sbjct: 122 VVGTTSLRRRMQLLEKRPDLKVKDLRGNVNTRLRKLKEGQYDAIILAYIGLYRLDLLKDI 181

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
                 +  +P +GQ A+GIE   ++ R RE+   LNH  T +    ER   + +  GC 
Sbjct: 182 PYVEKLDFFIPPMGQAALGIEIVANNDRIREIAMTLNHEPTFICTKVERDFISVIGAGCS 241

Query: 244 VPIGSYAELIDGE------IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
            P+   A +   E      I +RA++G PDG+ I+         +A+ +G  LA+ ++  
Sbjct: 242 APVAVNATMDKKEDDKVPTISVRAMIGYPDGTHILHKSLTVPLNEADILGDELAQAMIEE 301

Query: 298 GAREILAE----VYNGDAP 312
           GA +IL +     +  + P
Sbjct: 302 GALDILEQAEIIAFKDEMP 320


>UniRef50_B6FXV9 Putative uncharacterized protein n=1 Tax=Clostridium hiranonis DSM
           13275 RepID=B6FXV9_9CLOT
          Length = 299

 Score =  373 bits (958), Expect = e-102,   Method: Composition-based stats.
 Identities = 113/297 (38%), Positives = 176/297 (59%), Gaps = 1/297 (0%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +R+ TR S LAL Q ++  D+L    P +  E+  + T+GD IL   L K+G KGLFVKE
Sbjct: 3   IRVGTRGSNLALIQTNWAIDRLKEKFPEVEFEVKIIKTKGDKILHLSLDKIGDKGLFVKE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALPAGSI 124
           +E  LLE   D+AVHSMKD+P E  +GL    + +REDPRD  +     +S D LP G+ 
Sbjct: 63  IESQLLEGEIDLAVHSMKDMPAEVVEGLKFAAVPKREDPRDVIILREGLNSFDELPIGAT 122

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GT S RR+ QL  +RPDL I  +RGN+ TR+SK+++   D I+LA +G+ R  LE +I 
Sbjct: 123 IGTGSKRRKYQLLRKRPDLNIVPIRGNIETRISKIESENLDGIVLAASGVIRADLEEKIT 182

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             LP ++ +PA  QGA+ +E R +D    +++ A+    + ++  AER+    ++G C +
Sbjct: 183 EFLPVDLMIPAPAQGALALEIRENDEELEKMIDAIKDEISQIQTDAERSYLAGIDGSCHI 242

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           P+G+Y E+   ++ L  + G  DG +I      G   + +++G +LA+ +L     E
Sbjct: 243 PMGAYCEVDGEKLTLTGIFGDEDGEKITVASLEGDRDNPKELGSNLAKLVLKKHREE 299


>UniRef50_D2R3S6 Porphobilinogen deaminase n=2 Tax=Planctomycetaceae
           RepID=D2R3S6_9PLAN
          Length = 311

 Score =  373 bits (958), Expect = e-102,   Method: Composition-based stats.
 Identities = 144/299 (48%), Positives = 192/299 (64%), Gaps = 2/299 (0%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LR+ TR SPLA WQA +V+D+L+A+  G+ VE++ + T GD     PL ++GG+GLF KE
Sbjct: 7   LRLGTRASPLARWQADWVRDQLIAA--GIDVEMILITTEGDQQTSQPLGQIGGQGLFTKE 64

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           ++  LL    D+AVHS+KD+P     GL L  + ERED  D  +     SL  LP+G+ +
Sbjct: 65  IQRRLLAGDIDLAVHSLKDLPTLPIDGLSLAAVPEREDTADILIGPAGTSLATLPSGAKI 124

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GT SLRR+ QL   R DL I  +RGNV TRL KLD G+Y AIILA AGLKRL L+ R+  
Sbjct: 125 GTGSLRRKAQLLHARADLEILDIRGNVDTRLRKLDEGQYHAIILAAAGLKRLKLDDRMTE 184

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L   + LPAVGQGA+GIE R DD  TR+LLA L+H  T   V AER++   L  GC  P
Sbjct: 185 RLEAPLMLPAVGQGALGIESRSDDPTTRKLLAPLSHAPTLQAVIAERSLLAALRAGCLAP 244

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304
           +G++A+++DG++ L A+V + DG   +      AP DA Q+G  +AE L   GA E+LA
Sbjct: 245 VGAHAQVVDGQLTLAAVVLSIDGQSRLFASLTSAPADAAQLGEEVAELLRQQGATELLA 303


>UniRef50_Q43316 Porphobilinogen deaminase, chloroplastic n=61 Tax=cellular
           organisms RepID=HEM3_ARATH
          Length = 382

 Score =  372 bits (955), Expect = e-101,   Method: Composition-based stats.
 Identities = 137/303 (45%), Positives = 185/303 (61%), Gaps = 8/303 (2%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGL----VVELVPMVTRGDVILDTPLAKVGGKG 60
           ++RI TR SPLAL QA+  ++KL   HP L     + +  + T GD IL  PLA +GGKG
Sbjct: 74  IIRIGTRGSPLALAQAYETREKLKKKHPELVEDGAIHIEIIKTTGDKILSQPLADIGGKG 133

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LF KE++ AL+    DIAVHSMKDVP   P+   L     RED RDAF+     +L  LP
Sbjct: 134 LFTKEIDEALINGHIDIAVHSMKDVPTYLPEKTILPCNLPREDVRDAFICLTAATLAELP 193

Query: 121 AGSIVGTSSLRRQCQLAERRPDLII-RSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179
           AGS+VGT+SLRR+ Q+  + P L +  + RGNV TRLSKL  G+  A +LA+AGLKRL +
Sbjct: 194 AGSVVGTASLRRKSQILHKYPALHVEENFRGNVQTRLSKLQGGKVQATLLALAGLKRLSM 253

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
              + + L  +  LPAV QGA+GI CR DD +    LA+LNH ET L ++ ERA    L+
Sbjct: 254 TENVASILSLDEMLPAVAQGAIGIACRTDDDKMATYLASLNHEETRLAISCERAFLETLD 313

Query: 240 GGCQVPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGA--PQDAEQMGISLAEELLN 296
           G C+ PI  YA +  +G    R LV +PDG++++   R+G    +D  +MG    +ELL+
Sbjct: 314 GSCRTPIAGYASKDEEGNCIFRGLVASPDGTKVLETSRKGPYVYEDMVKMGKDAGQELLS 373

Query: 297 NGA 299
              
Sbjct: 374 RAG 376


>UniRef50_D0LUE1 Porphobilinogen deaminase n=1 Tax=Haliangium ochraceum DSM 14365
           RepID=D0LUE1_HALO1
          Length = 320

 Score =  371 bits (953), Expect = e-101,   Method: Composition-based stats.
 Identities = 157/315 (49%), Positives = 197/315 (62%), Gaps = 11/315 (3%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M +  + I+TR S LALWQAH+V+D++    P   VELV + T+GD ILD PL+K+GGK 
Sbjct: 1   MSERTIHISTRGSQLALWQAHHVRDEIRRVRPAWQVELVIIKTQGDKILDVPLSKIGGKA 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKE+E ALL+ RAD+AVHSMKDVP E   GL +     REDP DA  + +   LD L 
Sbjct: 61  LFVKEIEQALLDGRADVAVHSMKDVPAELAPGLFMAATSRREDPYDALCTRDGRGLDELA 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ +GTSSLRRQCQ+  RRPDL I  LRGNV TRL KLD+G +DA+ILA AGLKRLG  
Sbjct: 121 EGATLGTSSLRRQCQILARRPDLRIEMLRGNVPTRLGKLDDGSFDAVILAAAGLKRLGHG 180

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDD-----SRTRELLAALNHHETALRVTAERAMN 235
            RI   L   + +PAVGQG +GIE R  D          L  AL+      RV AERAM 
Sbjct: 181 ERISQRLDGGVCVPAVGQGVLGIETRQGDAPADRELVEALREALHDPAEERRVVAERAMM 240

Query: 236 TRLEGGCQVPIGSYAELID------GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGIS 289
             L G CQ P+ ++A          G + +  L G PDGS+I+R +  G  +DA+ +G S
Sbjct: 241 AALGGSCQTPLAAHASYRGDSDPVAGTLVIEGLCGRPDGSEILRAQVEGRAEDAQALGSS 300

Query: 290 LAEELLNNGAREILA 304
           LAEEL   GA+ I+ 
Sbjct: 301 LAEELRGQGAQAIID 315


>UniRef50_A5VM67 Porphobilinogen deaminase n=9 Tax=Lactobacillus RepID=HEM3_LACRD
          Length = 305

 Score =  371 bits (953), Expect = e-101,   Method: Composition-based stats.
 Identities = 118/298 (39%), Positives = 167/298 (56%), Gaps = 4/298 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           + N + + +R+S LA+ Q   V   L    P +  E+  ++T GD      LAK+GGKG+
Sbjct: 1   MTNKVIVGSRKSKLAMAQTELVIASLEKIFPDIKFEIKNVITEGDRNRHVSLAKIGGKGV 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALP 120
           FVKE+E  L +   D AVHS+KDV    P+ L L    +R  P D  VS     SL+ LP
Sbjct: 61  FVKEIEDELKDGTIDFAVHSLKDVMPILPEELVLGAFPKRVSPYDCLVSRKNLSSLNDLP 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ +GT+SLRRQ QL   RPDL I  +RGN+ TRL K+D    D IILA AGL RL ++
Sbjct: 121 KGARIGTNSLRRQGQLLSIRPDLKIIPIRGNIDTRLRKIDTEALDGIILAEAGLTRLNID 180

Query: 181 SRIRAALPPE-ISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
                 L  +   +PAVGQG + IECR +D+R R++L  +N  E+A  V  ER     L 
Sbjct: 181 LSSYHVLDLQNYIMPAVGQGCLAIECRKNDTRIRKMLDQINDEESAYCVQVEREFMRELG 240

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           G C  PIG +A   +G+I    L+ +P+G  +I+  +   P +   +G  +A++LL  
Sbjct: 241 GSCNFPIGGHAYAKNGQILFDGLIASPNGEHVIKETKI--PANNSGVGKKVADQLLAK 296


>UniRef50_O94048 Porphobilinogen deaminase n=53 Tax=Saccharomyceta RepID=HEM3_CANAL
          Length = 340

 Score =  368 bits (946), Expect = e-100,   Method: Composition-based stats.
 Identities = 131/319 (41%), Positives = 186/319 (58%), Gaps = 17/319 (5%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62
            N ++I  R+S LA+ Q+  VK  +  + P L   ++ + T GD +   PL   GGK L+
Sbjct: 11  SNHVQIGGRKSKLAVVQSEIVKKVIEDTFPNLSCSILALSTLGDKVQTQPLYTFGGKSLW 70

Query: 63  VKELEVALLEN-----RADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YD 114
            KELE+ LL++     + D+ VHS+KD+P   P+   L  I +REDPRDA V      Y 
Sbjct: 71  TKELEILLLDSVDEFPKLDLIVHSLKDMPTNLPEEFELGCIFQREDPRDAIVMKQGSSYK 130

Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVA 172
           SL  LPAG+IVGTSS+RR  QL +  P L   S+RGN+ TRL+KLD  N EY  +ILA A
Sbjct: 131 SLKDLPAGAIVGTSSIRRSSQLIKNYPHLRFESVRGNIQTRLNKLDQPNNEYCCLILASA 190

Query: 173 GLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232
           GL RLGL  RI +    +    AVGQGA+GIE R  D   + +L  +      +   AER
Sbjct: 191 GLIRLGLGHRITSY--LDDMYYAVGQGALGIEIRKGDDNIKSILKKIEDPIATICCLAER 248

Query: 233 AMNTRLEGGCQVPIGSYAELIDG--EIWLRALVGAPDGSQIIRGE---RRGAPQDAEQMG 287
           ++   LEGGC VP+G +++  +   E+ L+ ++ +PDG+  I  E   R    +D EQ+G
Sbjct: 249 SLMRYLEGGCSVPLGVHSDYNESKQELTLKGIIVSPDGTVSIEDEVIKRITCDEDCEQVG 308

Query: 288 ISLAEELLNNGAREILAEV 306
           I L ++L   GA+EIL ++
Sbjct: 309 IELGDKLKAKGAKEILDKI 327


>UniRef50_Q3YSA8 Porphobilinogen deaminase n=17 Tax=Rickettsiales RepID=HEM3_EHRCJ
          Length = 298

 Score =  368 bits (945), Expect = e-100,   Method: Composition-based stats.
 Identities = 112/293 (38%), Positives = 175/293 (59%), Gaps = 3/293 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR S LAL Q   V + L    P + +++V + T GD+    P+  +GGKGLF+KE
Sbjct: 3   IRIGTRGSVLALAQTLEVTNLLNRYFPEINIQVVKIKTSGDINNKVPINTIGGKGLFIKE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E ALL  + D+AVHS+KD+P  +  GL +  + +R  P D FVS+ Y S+ +LP  + V
Sbjct: 63  IEEALLIGKVDLAVHSVKDIPAFYCDGLIIPCVLKRSSPYDVFVSSKYQSIKSLPINATV 122

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS+RR+ QL   RPDL +  +RGN+ TR+ K D GE+D I+LA AGL R+   + I+ 
Sbjct: 123 GTSSIRRKVQLNYLRPDLQVIPVRGNIDTRILKSDIGEFDGIVLAEAGLIRINKCNVIKE 182

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L  +I L AVGQGA+ ++CR DD      +  LN H++ + V AER+    + G C  P
Sbjct: 183 VLDSKIMLSAVGQGAICVQCRADDYNIINKIKVLNCHKSYVCVIAERSFLKTINGSCDTP 242

Query: 246 IGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           + + A+ +D   I++  ++      +++  +      +AE+ GI + ++L+N 
Sbjct: 243 LAALAQYVDSDTIYMSCMLSNE--KEMVFSDCYFKECNAEESGIDMGKKLINE 293


>UniRef50_C8WXM9 Porphobilinogen deaminase n=2 Tax=Alicyclobacillus acidocaldarius
           RepID=C8WXM9_ALIAD
          Length = 305

 Score =  367 bits (943), Expect = e-100,   Method: Composition-based stats.
 Identities = 151/301 (50%), Positives = 196/301 (65%), Gaps = 2/301 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             LR+ATR+S LAL Q ++V D L     G+  ELVP+ TRGD I+D  L++VGGKGLFV
Sbjct: 2   RTLRVATRRSALALTQTNHVVDLLKQVAHGVEFELVPIRTRGDEIVDRALSEVGGKGLFV 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
            ++E AL   +AD+AVHS+KDVP E   GL +  +  REDPRDA +S     L  LP G+
Sbjct: 62  ADIEDALATGQADLAVHSLKDVPFELRDGLTIGAVPPREDPRDALISRTGQGLFDLPPGA 121

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            VGTSSLRRQ  L   RPDL + +LRGNV TRL +L+ G++DAI+LA +GL RLGL  RI
Sbjct: 122 RVGTSSLRRQAALRRLRPDLCVETLRGNVDTRLRRLEEGQFDAIVLAASGLHRLGLAERI 181

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              LP +  +PAVGQGA+ IECR +D      LAA+   +    V AERA  +RLEG CQ
Sbjct: 182 TEYLPVDRFVPAVGQGALAIECRAEDDEVMRHLAAIADPDATRAVEAERAFLSRLEGSCQ 241

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           VPIG+YAE +  E+ L A V  P G   ++ ER G   +A  +G+++AEE+L  GA + L
Sbjct: 242 VPIGAYAEPVGHELRLIAFVADPSGIHHLQLERTG--DEARALGVAMAEEMLRQGAEDWL 299

Query: 304 A 304
            
Sbjct: 300 K 300


>UniRef50_A8LIJ6 Porphobilinogen deaminase n=11 Tax=Alphaproteobacteria
           RepID=A8LIJ6_DINSH
          Length = 347

 Score =  365 bits (938), Expect = 1e-99,   Method: Composition-based stats.
 Identities = 144/297 (48%), Positives = 190/297 (63%), Gaps = 2/297 (0%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           D+ L+I TR S LAL QAH  + +L A+   P    E+V + T GD I D  L+++GGKG
Sbjct: 38  DSPLKIGTRGSLLALAQAHETRARLSAAFDLPEEAFEIVVIKTTGDRIQDRSLSEIGGKG 97

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LF +E+E A+L+   DIAVHSMKD+PV+ P GL L T   RED RDAFV+ +  +L  LP
Sbjct: 98  LFTREIEDAMLDGSIDIAVHSMKDMPVDTPAGLALDTYLPREDVRDAFVTLDGGTLADLP 157

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G++VG+SSLRR+ QLA RRPDL +   RGNV TR+ KL +G   A  LA+AGL RLG++
Sbjct: 158 EGAVVGSSSLRRRAQLAHRRPDLQLVEFRGNVQTRMKKLGDGVAHATFLAMAGLNRLGMD 217

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
              R+A+ PE  LPAV QG +GIE R DD R  E+LAA++   +  R+  ERA  + L+G
Sbjct: 218 EVPRSAIAPEDMLPAVAQGCIGIERRADDPRAAEMLAAIHDGPSGHRLACERAYLSALDG 277

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
            CQ PI   AEL  G I LRA +  PDGS+++        +DA +MG  +AE L   
Sbjct: 278 SCQTPIAGLAELDGGSIHLRAEILRPDGSEVLSDSETAPVEDAAKMGREVAERLRAR 334


>UniRef50_P28789 Porphobilinogen deaminase n=18 Tax=Saccharomycetales
           RepID=HEM3_YEAST
          Length = 327

 Score =  364 bits (936), Expect = 2e-99,   Method: Composition-based stats.
 Identities = 123/322 (38%), Positives = 177/322 (54%), Gaps = 15/322 (4%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M    L I  R+S LA+ Q+++V   +   +P    ++  + T GD I   PL   GGK 
Sbjct: 1   MGPETLHIGGRKSKLAVIQSNHVLKLIEEKYPDYDCKVFTLQTLGDQIQFKPLYSFGGKA 60

Query: 61  LFVKELEVALL----ENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NY 113
           L+ KELE  L       + D+ VHS+KD+P   P+G  L  I +R DP D  V      Y
Sbjct: 61  LWTKELEDHLYHDDPSKKLDLIVHSLKDMPTLLPEGFELGGITKRVDPTDCLVMPFYSAY 120

Query: 114 DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAV 171
            SLD LP G IVGTSS+RR  QL  + P L   S+RGN+ TRL KLD+ +  Y  IILA 
Sbjct: 121 KSLDDLPDGGIVGTSSVRRSAQLKRKYPHLKFESVRGNIQTRLQKLDDPKSPYQCIILAS 180

Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231
           AGL R+GLE+RI      +    AVGQGA+GIE R  D++  ++L  +      +   +E
Sbjct: 181 AGLMRMGLENRITQRFHSDTMYHAVGQGALGIEIRKGDTKMMKILDEICDLNATICCLSE 240

Query: 232 RAMNTRLEGGCQVPIGSYAELIDG--EIWLRALVGAPDGSQIIRGE----RRGAPQDAEQ 285
           RA+   LEGGC VPIG  ++  +   ++ L+A+V   +G++ +  E         +D+  
Sbjct: 241 RALMRTLEGGCSVPIGVESKYNEETKKLLLKAIVVDVEGTEAVEDEIEMLIENVKEDSMA 300

Query: 286 MGISLAEELLNNGAREILAEVY 307
            G  LAE ++ +GA++IL E+ 
Sbjct: 301 CGKILAERMIADGAKKILDEIN 322


>UniRef50_A9A1A1 Probable porphobilinogen deaminase n=3 Tax=Thaumarchaeota
           RepID=HEM3_NITMS
          Length = 311

 Score =  364 bits (936), Expect = 2e-99,   Method: Composition-based stats.
 Identities = 107/296 (36%), Positives = 171/296 (57%), Gaps = 2/296 (0%)

Query: 7   RIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66
            +  R S L++ Q + V  +L  +HP    E+  + T+GD     PL  +  KG+F KE+
Sbjct: 4   IVGARGSQLSVAQTNLVIAELKKAHPDTEYEIKTITTKGDTD-SRPLFTIDQKGIFEKEI 62

Query: 67  EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126
           + A+ +   D AVHS+KDVP E    L L  I +RE   D F+S +  +LD++  GS++G
Sbjct: 63  DRAVAQKEVDFAVHSLKDVPSELDDNLVLACIPKRETVNDVFISPDGSTLDSIKPGSVIG 122

Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAA 186
           TSSLRR  Q++ +RPD+ ++ +RGN+ TR+ K     YDAI+LA AG+ RLG++ +    
Sbjct: 123 TSSLRRAVQVSRKRPDVTVKPIRGNIETRIKKASGENYDAIVLAKAGISRLGVDVKYTE- 181

Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246
           L  +   P+ GQGA+ I  R DDS+T E+L  +   ++ L + AERA++  ++ GC+ P+
Sbjct: 182 LSTDDFSPSPGQGAIAIVARADDSKTIEMLKKIEDPDSRLEIEAERALSDFVDSGCRFPV 241

Query: 247 GSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302
           G+YA+    E+ L     + DG Q +   + G   + + +G S  EEL   G  ++
Sbjct: 242 GAYAKSNGSEMTLTVTAFSVDGKQFLHVSKTGDKNNPKSLGQSAGEELREKGVNDL 297


>UniRef50_C1CYD9 Porphobilinogen deaminase n=3 Tax=Deinococci RepID=HEM3_DEIDV
          Length = 311

 Score =  364 bits (936), Expect = 2e-99,   Method: Composition-based stats.
 Identities = 126/306 (41%), Positives = 178/306 (58%), Gaps = 5/306 (1%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDT--PLAKVGGKGL 61
             + + TR S LAL Q  +V  +L    P     +  + T+GD   ++   +A+ G KG 
Sbjct: 2   RTVTVGTRGSTLALAQTRWVVARLKEEWPDTDFRIQTISTKGDRNRESLEAMAQKGDKGF 61

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALP 120
           +VKE+E ALL+ R DIAVHS+KD+P E P+GL + +I +R D RD  +       L  LP
Sbjct: 62  WVKEIEDALLQKRIDIAVHSLKDLPTEQPEGLEVASIPKRVDARDVLIGKEGMKRLADLP 121

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ VGTSS+RR+  L   RPDL +  LRGN+ TRL+ L   EYDAIILA AGL R  + 
Sbjct: 122 QGARVGTSSVRRKAFLRAYRPDLQVIDLRGNIDTRLAALAGDEYDAIILAAAGLIRTEMR 181

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRL--DDSRTRELLAALNHHETALRVTAERAMNTRL 238
            RI   + P+I LPA GQGA+ +E R   ++  T E+  A++ H T  R+TAER     L
Sbjct: 182 HRIDEFVEPDILLPAPGQGALALETRSGPENDLTIEVAYAIHDHGTDDRITAEREFLAGL 241

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
             GC  P+G++A +  G + L   VGA DGS++IR    G P +   +G  LA ++L  G
Sbjct: 242 GAGCMAPVGAHASIKGGVLTLEGWVGALDGSKVIRATSIGDPAECADIGAELAGDMLGQG 301

Query: 299 AREILA 304
           A+ ++ 
Sbjct: 302 AQALID 307


>UniRef50_D1CBT4 Porphobilinogen deaminase n=1 Tax=Thermobaculum terrenum ATCC
           BAA-798 RepID=D1CBT4_THET1
          Length = 300

 Score =  363 bits (933), Expect = 4e-99,   Method: Composition-based stats.
 Identities = 112/297 (37%), Positives = 171/297 (57%), Gaps = 2/297 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
            V+++ TR S LALWQ  +V ++L + +PG   E V +    D   D P++ +G  G+F 
Sbjct: 2   KVIKVGTRGSKLALWQTQWVINRLRSLYPGFQFEPVVIKVTSDRSPDAPISAIGQVGVFT 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           K++E ALL     +AVHS+KD+P     G  +    EREDPRD  +      +  L   S
Sbjct: 62  KDIEQALLAGDIHLAVHSLKDLPTLSTPGTVIAAFTEREDPRDCILWPKGQPMPDL-NNS 120

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            VGTSS+RR   +    P+  + +LRGNV TR+ K+  G YD +++A A +KR+ L    
Sbjct: 121 RVGTSSVRRSALVRSYWPNANVVNLRGNVDTRVRKMLEGNYDVVLMAYAAVKRMDLPVEF 180

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
           +  LP +  +P+ GQG + ++ R DD +   +L A+N   + +   AER++   L GGC 
Sbjct: 181 K-PLPLDSWVPSAGQGIIAVQAREDDQQIIGMLNAINFFPSKVAYLAERSLMRALGGGCS 239

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           +P+G+YAEL DGE+ L  +V APDGSQ++   R   P  A+ +G  +A E+L+ G R
Sbjct: 240 MPVGAYAELHDGELSLIGMVAAPDGSQVVITRRVDTPDQADHLGERVAREMLDLGIR 296


>UniRef50_Q8RFP5 Porphobilinogen deaminase n=16 Tax=Fusobacteriaceae
           RepID=HEM3_FUSNN
          Length = 298

 Score =  362 bits (929), Expect = 1e-98,   Method: Composition-based stats.
 Identities = 119/298 (39%), Positives = 166/298 (55%), Gaps = 5/298 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPL--AKVGGK 59
           +   + I +R S LAL QA+ VKD+L  ++P L  E+  +VT GD  L +    + +  K
Sbjct: 1   MKKNIIIGSRGSILALAQANLVKDRLQGNYPNLSFEIKEIVTSGDKDLKSNWENSDISLK 60

Query: 60  GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119
             F KE+E  LL+   DIAVHSMKD+P    + L    I +REDPRD  VS N   L  L
Sbjct: 61  SFFTKEIEQELLDGEIDIAVHSMKDMPAVSAKSLICGAIPDREDPRDVLVSKNGL-LVTL 119

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179
           P G+ VGTSSLRR   L   RPD  I+ LRGN+ TRL KL+  +YDAI+LA AGLKR GL
Sbjct: 120 PQGAKVGTSSLRRAMNLKTVRPDFEIKHLRGNIHTRLKKLETEDYDAIVLAAAGLKRTGL 179

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
             +I   L  E+  PA  QG + I+CR +D   +E+L ++++   A  V  ER  +   +
Sbjct: 180 ADKITEYLNGEVFPPAPAQGVLYIQCRENDEEIKEILKSIHNEAIAKIVEIEREFSKIFD 239

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           GGC  P+G Y+++   +I   A+    D  + IR          +++    AEE+ N 
Sbjct: 240 GGCHTPMGCYSQVNGDKIKFTAVY--LDEGKQIRAVVEDDLAKGKEIAYMAAEEIKNK 295


>UniRef50_C3XEZ5 Porphobilinogen deaminase n=3 Tax=Campylobacterales
           RepID=C3XEZ5_9HELI
          Length = 328

 Score =  361 bits (928), Expect = 1e-98,   Method: Composition-based stats.
 Identities = 147/315 (46%), Positives = 191/315 (60%), Gaps = 12/315 (3%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62
           +  L + TR S LALWQA+++K+KL +   G  V L  + T+GD ILD PLAK+GGKGLF
Sbjct: 12  EKPLVLGTRGSLLALWQANHIKEKLESL--GFQVVLKTIKTKGDKILDAPLAKIGGKGLF 69

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122
            KELE  LL    D AVHS+KDVP+  P  L LV+I +RED RD FVS  Y  + +LP G
Sbjct: 70  TKELENELLSGGIDFAVHSLKDVPIAIPPELMLVSITQREDARDCFVSEKYADIASLPQG 129

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           + VGT+SLRR  QL   R DL  +SLRGNV TRL KL  GE+DAIILA AGL RL L+  
Sbjct: 130 AKVGTTSLRRSMQLKRIRQDLDTQSLRGNVQTRLEKLRKGEFDAIILASAGLNRLDLKDD 189

Query: 183 IRAALPPEI--SLPAVGQGAVGIECRL-------DDSRTRELLAALNHHETALRVTAERA 233
           I      +I   +PA+GQG++GIECR         D    ++L +L+  ++AL    ERA
Sbjct: 190 IGFISHLQINQFIPAMGQGSLGIECRDPKYSPDFRDQAIMKVLESLHDSKSALCCNIERA 249

Query: 234 MNTRLEGGCQVPIGSYAELIDG-EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAE 292
               L GGCQ PIG +A+++D  EI ++ +VG  D S+++   R     + E     +  
Sbjct: 250 FIQLLGGGCQSPIGIHAQILDSKEIEIQCVVGNLDASKVLTETRVCNKGEVEYALQDMIN 309

Query: 293 ELLNNGAREILAEVY 307
            L  NG  EIL EV 
Sbjct: 310 TLKKNGVMEILEEVR 324


>UniRef50_Q5HBG1 Porphobilinogen deaminase n=2 Tax=Ehrlichia ruminantium
           RepID=Q5HBG1_EHRRW
          Length = 299

 Score =  361 bits (927), Expect = 2e-98,   Method: Composition-based stats.
 Identities = 112/298 (37%), Positives = 177/298 (59%), Gaps = 3/298 (1%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M    + + TR S LA+ QA  VK  L    P + V++V +VT GD+     L+++GGKG
Sbjct: 1   MNSMNVYVGTRGSILAIAQAMEVKKLLYNYFPDINVQIVHIVTSGDINDKISLSEIGGKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LF+KELE ALL    D+AVHSMKDVP  +   L +  I +R  P D F+S+ Y SL +LP
Sbjct: 61  LFLKELEEALLTGTIDLAVHSMKDVPAFYCDSLVIPCILKRSSPYDVFISSKYQSLRSLP 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
             +++GTSS+RR+ QL      + +  +RGNV TR+ KL+ G+YD IILA AGL R+   
Sbjct: 121 DNAVIGTSSIRRKVQLMRLLSSVQVVPIRGNVDTRILKLEAGQYDGIILAKAGLMRINKT 180

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
             I+  L P++ L AVGQGA+GI+CR +D +  +++  LN  ++ + V AER+    + G
Sbjct: 181 HVIKEVLDPQVMLSAVGQGAIGIQCRANDYKMIDMIKILNCKKSYISVAAERSFMKTVNG 240

Query: 241 GCQVPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
            C  P+ + A+ ++   +++  ++   +  + +  +      DAE  GI++  +L++ 
Sbjct: 241 SCDTPLAALAKYVNSDTLYMSCMLSNEE--KTVFSDCYFNECDAEISGINMGNDLMDQ 296


>UniRef50_UPI00017922DC PREDICTED: similar to porphobilinogen deaminase n=1
           Tax=Acyrthosiphon pisum RepID=UPI00017922DC
          Length = 377

 Score =  360 bits (926), Expect = 3e-98,   Method: Composition-based stats.
 Identities = 130/359 (36%), Positives = 186/359 (51%), Gaps = 59/359 (16%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             +R+ +R+S LAL Q  +V  +L   HP +  E+V M T GD +LD PL K+G K LF 
Sbjct: 7   KTIRVGSRKSELALIQTKFVISQLKELHPEIEFEIVSMTTMGDRVLDKPLPKIGEKSLFT 66

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLDALP 120
           K+LEVALL    D  VHS+KD+P     G  +  I +R+DPRDA V  +      LD+LP
Sbjct: 67  KDLEVALLSGTVDFIVHSLKDLPTVMEIGTTIGAILKRDDPRDALVLRDDCKEYQLDSLP 126

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE---------YDAIILAV 171
           + S +GTSSLRR  QL  + P+L +  +RGN+ TRL KLD+ +         Y  IILA+
Sbjct: 127 SKSFIGTSSLRRTAQLKRKFPNLQVSDVRGNLNTRLKKLDSSQSTGDNTNTNYSGIILAL 186

Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231
           AG++R+G E R+   +  ++ L AVGQGA+ +ECRL D    E+L  L+H+ET L+V AE
Sbjct: 187 AGIQRMGWEKRVSQIIDSDVMLYAVGQGALAVECRLGDDYILEMLEPLHHYETVLQVVAE 246

Query: 232 RAMNTRLEGGCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQD------- 282
           R   TRL GGC  P+G  + +      + L   V + DG++ ++        D       
Sbjct: 247 RGFLTRLGGGCSAPVGIRSTVCLTKNAMSLDGAVWSLDGAEELQYSSSAELADKKVIQSH 306

Query: 283 --------------------------------------AEQMGISLAEELLNNGAREIL 303
                                                 A ++G  LAE L++ GA +I+
Sbjct: 307 IDQYRGEDGEPPKKCPYKQPRQFVGVTPGKISYLDLDTALKLGTELAENLISKGALDIM 365


>UniRef50_B0K2L4 Porphobilinogen deaminase n=7 Tax=Bacteria RepID=B0K2L4_THEPX
          Length = 299

 Score =  360 bits (926), Expect = 3e-98,   Method: Composition-based stats.
 Identities = 110/296 (37%), Positives = 172/296 (58%), Gaps = 3/296 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +  V+++ TR S LAL Q   V +++         E+V + T+GD ++D P++++GGKG+
Sbjct: 1   MKKVIKVGTRSSELALKQTAMVINEIKKFRQDFEFEIVKITTQGDALIDKPVSEIGGKGV 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FVKE+E ALL+   D+AVHSMKD+P E P+GL L+ + +REDP+D FVS +      L  
Sbjct: 61  FVKEIESALLKGEIDMAVHSMKDMPYEIPKGLKLMAVLKREDPKDVFVSGDGTQFMDLKE 120

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ +GTSSLRRQ QL   +PD+ I  +RGNV TRL K++    D I+L+ AGL RLGLE+
Sbjct: 121 GAKIGTSSLRRQVQLKALKPDIQIVPIRGNVRTRLKKMEELNLDGIVLSAAGLHRLGLEN 180

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            I    PP++ +PA  QG + +E     D+  +E    +   +T    + ER +      
Sbjct: 181 IITEYFPPDVVVPAPCQGILAVEIAESFDNIFQEFYPYIVDRKTFFEASVERELLKAFGV 240

Query: 241 GCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
            C+ P G+YA+    + E  +   V     +++++ E  G  ++ ++M   L EE 
Sbjct: 241 NCRQPFGAYAQYRKEEDEEKINIKVAYQKENKLLKSEVTGLIEETDKMIEKLIEEF 296


>UniRef50_Q4HT06 Porphobilinogen deaminase n=1 Tax=Campylobacter upsaliensis RM3195
           RepID=Q4HT06_CAMUP
          Length = 308

 Score =  359 bits (922), Expect = 8e-98,   Method: Composition-based stats.
 Identities = 151/304 (49%), Positives = 201/304 (66%), Gaps = 4/304 (1%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             L IATR+SPLALWQ+ +V D L  +H G+ V L    T+GD++LD+PLAK+GGKGLF 
Sbjct: 2   KKLIIATRKSPLALWQSEFVADILRKTH-GIEVHLEGFSTKGDILLDSPLAKIGGKGLFT 60

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KELE A+LEN+A +AVHS+KDVP   PQGL L  +  RED  DA +S  Y  L+ALP  +
Sbjct: 61  KELENAMLENKAHLAVHSLKDVPSFLPQGLVLAALSVREDDTDALLSELYKDLNALPQNA 120

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            VGT+SLRR+ QL   RPDL I +LRGNV +RL +L  GE+DAIILA AG+KRLGLES +
Sbjct: 121 KVGTTSLRRKMQLLSLRPDLHIINLRGNVNSRLKRLKGGEFDAIILASAGVKRLGLESEV 180

Query: 184 RAAL--PPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
           +       +  +PA  QG +GI+   D +    LL  LN  ++ +  T ER     LEGG
Sbjct: 181 KFIYRFSKDELVPAATQGILGIQS-PDKNEILTLLQCLNDEKSLIESTVERDFIRTLEGG 239

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           CQVPIG  AEL+  +I +R+++G PDGS+I+R +R    ++ +  G  LA E +  GA+E
Sbjct: 240 CQVPIGINAELMGEQITVRSILGLPDGSEILRDKRIILKKNYQGFGERLALEFIKRGAKE 299

Query: 302 ILAE 305
           +L  
Sbjct: 300 LLKR 303


>UniRef50_B3T8H9 Putative Porphobilinogen deaminase, dipyromethane cofactor binding
           domain protein n=1 Tax=uncultured marine microorganism
           HF4000_APKG5H11 RepID=B3T8H9_9ZZZZ
          Length = 322

 Score =  357 bits (918), Expect = 2e-97,   Method: Composition-based stats.
 Identities = 121/300 (40%), Positives = 170/300 (56%), Gaps = 1/300 (0%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            +++ +R S LAL Q H V ++L A+ P L  E+  + TRGDV   + LA +G  G+FVK
Sbjct: 17  AIKVGSRGSTLALIQDHVVINRLKANSPALEFEVDTVRTRGDVDQTSRLAGMGL-GIFVK 75

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           ELE  LL+ + DIAVHS+KD+P +   GL L  +  REDPRD  V+     LD LP G+ 
Sbjct: 76  ELEQELLDGKLDIAVHSLKDMPTQLADGLVLGAVLSREDPRDVLVNRYGCPLDGLPKGAK 135

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GTSS RR  QL +  P + + S+RGNV TRL K    E D  ILA AG+ RLGL+ +I 
Sbjct: 136 IGTSSPRRAAQLKQYAPQVEVVSIRGNVETRLRKAQGEEADGAILAAAGMIRLGLQDQIA 195

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L     +P  GQG + +E R DD R  ELL+A++  +T    TAER    RL GGC +
Sbjct: 196 EYLSATQFVPPPGQGILAVEARADDFRMLELLSAIDDADTRYEATAERGFLARLGGGCSI 255

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304
           P+G+YA      I +   +   DG +    + +G  +D  Q+       L+  G  +++A
Sbjct: 256 PVGAYARCNGDNIVMTIYMSTADGEKKFSAKIQGLKRDPLQLANDAYLALVERGGADLVA 315


>UniRef50_C3WGN0 Porphobilinogen deaminase n=5 Tax=Fusobacterium RepID=C3WGN0_9FUSO
          Length = 301

 Score =  357 bits (916), Expect = 4e-97,   Method: Composition-based stats.
 Identities = 123/311 (39%), Positives = 173/311 (55%), Gaps = 13/311 (4%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPL--AKVGGK 59
           +   + I +R S LAL QA  VK+ L A++P L  E+  +VT GD  L +    +    K
Sbjct: 1   MKRHVVIGSRGSILALAQASLVKNSLEANYPDLTFEIKEIVTSGDKDLKSNWENSNASLK 60

Query: 60  GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119
             F KE+E  LL+ + DIAVHSMKD+P   P+GL    I +RED RD  +S N   L  L
Sbjct: 61  SFFTKEIEQELLDGQIDIAVHSMKDMPAVSPKGLICGAIPDREDARDVLISKNG-FLVTL 119

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179
           P G+ +GTSSLRR   L   RPD  I+ LRGN+ TRL KL+  +YDAIILA AGLKR G+
Sbjct: 120 PQGAKIGTSSLRRVMNLKAIRPDFEIKHLRGNIHTRLKKLETEDYDAIILAAAGLKRTGM 179

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
             +I   L  E   PA  QG + I+CR +D   + +L ++++ + A  V  ER  +   +
Sbjct: 180 ADKITEYLSGEAFPPAPAQGVLYIQCRENDEEIKGILKSIHNEDIAKIVEIEREFSKIFD 239

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
           GGC  P+G Y+++ + +I   A   + DG QI     R   +D    G  +A    +  A
Sbjct: 240 GGCHTPMGCYSQVDEDKIKFIAA-YSHDGKQI-----RVVIEDDLTKGKEIA----HMAA 289

Query: 300 REILAEVYNGD 310
            EI A++  G+
Sbjct: 290 EEIKAKINKGN 300


>UniRef50_C6XGK7 Porphobilinogen deaminase n=1 Tax=Candidatus Liberibacter asiaticus
           str. psy62 RepID=C6XGK7_LIBAP
          Length = 307

 Score =  356 bits (915), Expect = 5e-97,   Method: Composition-based stats.
 Identities = 113/297 (38%), Positives = 162/297 (54%), Gaps = 2/297 (0%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGG 58
           M     RI TR SPLAL  A   +  LM  H  P   + ++P+ T+GD I +  L ++GG
Sbjct: 1   MEKKPFRIGTRCSPLALAHAFETRSSLMDVHKIPPHNIVIIPLSTKGDRITNRTLTEIGG 60

Query: 59  KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118
           KGLF +E+E  L+    D AVHS KD+P +  +GL +     RED RD F+S+   SL  
Sbjct: 61  KGLFTEEIEKKLISGEIDCAVHSAKDMPTKLLKGLQISAYLPREDIRDVFISHTAQSLKD 120

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178
           L   S++GTSSLRR+  L   R D+ +   RG + TRL+KL+N +  AI+LA AG+KRL 
Sbjct: 121 LALHSVIGTSSLRRKALLLRWRSDISVIDFRGKIETRLNKLNNNKAHAILLAYAGIKRLK 180

Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
            E  I+  L  E   P+ GQGA+ IE  +++ + +EL+  +NH +T   V  ERA    L
Sbjct: 181 KEKVIKEILNIEDFPPSPGQGAICIETHVNNPKAQELVKVINHEDTWDSVNCERAFLAEL 240

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295
           +G C+  I  +A      ++   +V A DG       R G   DA  +G   A+ + 
Sbjct: 241 DGSCKSAIAGFAYCKGSTLYFYGIVLASDGKIFHEVSRNGNRCDAINIGRDAAQYIR 297


>UniRef50_UPI0001926E0E PREDICTED: similar to hydroxymethylbilane synthase, partial n=1
           Tax=Hydra magnipapillata RepID=UPI0001926E0E
          Length = 418

 Score =  355 bits (913), Expect = 9e-97,   Method: Composition-based stats.
 Identities = 123/342 (35%), Positives = 167/342 (48%), Gaps = 35/342 (10%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62
              + + +R+S LA+ Q   +   L      +   +  M T GD IL   L K+G K LF
Sbjct: 28  KTSVVVGSRKSQLAVIQTKSIVAALCQKEKDVECIIETMDTLGDKILHIALPKIGEKSLF 87

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDAL 119
            K+LE+AL E R D  VHS+KD+P   PQG+ + TI +R+DPRD  + +   N   L  L
Sbjct: 88  TKDLELALSEKRVDFLVHSLKDLPTTLPQGMAISTIYKRDDPRDCIIFHPKHNGKKLADL 147

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-YDAIILAVAGLKRLG 178
           P  SI+GTSSLRR  QL  +   L  +S+RGN+ TRL KL+    YDAI+LA AG+ R+G
Sbjct: 148 PENSIIGTSSLRRVAQLKRKYNKLTFQSVRGNLNTRLQKLEEESLYDAIVLAKAGVDRMG 207

Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
              +I   L  +  L A+GQGA+ +E R DD  T  +LA L   ET L   AER     L
Sbjct: 208 WTEKIGQILSEDECLYAIGQGAITVEVRNDDKYTISILAQLTDMETLLACVAERCFMRTL 267

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ----------------- 281
            GGC  PI  +++       LR +V   DGS+ +        Q                 
Sbjct: 268 NGGCSTPIACHSQFSGNNYSLRGIVLNADGSRFLDSTVSTTLQVNILTDQNEPPSYTVSK 327

Query: 282 --------------DAEQMGISLAEELLNNGAREILAEVYNG 309
                          AE+ G  LA  L   GA ++L EV + 
Sbjct: 328 SGVVINSLYINEFIKAEKCGEELAYCLKKLGADDVLKEVRSK 369


>UniRef50_UPI0000583C22 PREDICTED: hypothetical protein n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000583C22
          Length = 324

 Score =  355 bits (912), Expect = 1e-96,   Method: Composition-based stats.
 Identities = 125/315 (39%), Positives = 179/315 (56%), Gaps = 13/315 (4%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
            ++R+ +R+S LA+ Q ++V + L   HP    ++V M T GD I D PLA +G   LF 
Sbjct: 6   EIVRVGSRKSELAMIQTNHVVEMLQKVHPETEFKIVTMETIGDHIQDKPLASIGESNLFT 65

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALP 120
           KELE AL  +  D+ VHS+KD+P   P  + +  ICEREDP DA V +      S++ + 
Sbjct: 66  KELEKALALDEVDMLVHSLKDMPSRLPSNMAIGAICEREDPHDALVLHKKLTGISIETMK 125

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-YDAIILAVAGLKRLGL 179
            GS++GTSS+RR  QL  + P L+ + +RGN+ TRL KLD G+ YD ++LAVAG+ R+G 
Sbjct: 126 EGSVLGTSSVRRVAQLKRKFPHLVFKDVRGNLNTRLRKLDEGQVYDGLVLAVAGMMRMGW 185

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
           E RI   L P+I   +V QGA+GIE +  + R  ELL  LNH  T +R  AER +   LE
Sbjct: 186 EHRISQILKPDICKYSVSQGALGIEIKTKNRRMHELLRQLNHVPTLIRCIAERGLLKTLE 245

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGA------PQDAEQMGISLAEE 293
           GGC  P+  ++EL +    L A     +    +              Q+AE +G+S+A+ 
Sbjct: 246 GGCSAPVAVHSELEENRHSLDAET---NEEMKLFSSVIAPWVSQHAMQEAEALGVSVAKG 302

Query: 294 LLNNGAREILAEVYN 308
           L + GA  IL     
Sbjct: 303 LFDKGAGPILEAAKE 317


>UniRef50_Q2S2A6 Porphobilinogen deaminase n=1 Tax=Salinibacter ruber DSM 13855
           RepID=Q2S2A6_SALRD
          Length = 323

 Score =  354 bits (910), Expect = 2e-96,   Method: Composition-based stats.
 Identities = 144/308 (46%), Positives = 193/308 (62%), Gaps = 5/308 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           + + L + TR S LAL QA+ V+ +L A+  G  VEL  + TRGD   DTP++++G + +
Sbjct: 3   ISDPLVLGTRGSELALRQANVVRSRLEAA--GHRVELETITTRGDEATDTPISEIGDEAV 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN--YDSLDAL 119
           F KEL+ ALL+   D+AVHS+KD+P   P GL L  I EREDPRDAFV++      L  L
Sbjct: 61  FTKELDRALLQGGVDLAVHSLKDIPSTVPSGLALAAIGEREDPRDAFVAHPSFDGHLHDL 120

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179
           P G+ V T+SLRR  QL   R DL +  +RGNV TRL KL   ++  ++LAVAGL RLGL
Sbjct: 121 PEGATVATASLRRTAQLLTWRSDLEVVPVRGNVDTRLEKLGESDWTGMVLAVAGLVRLGL 180

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAA-LNHHETALRVTAERAMNTRL 238
              IR  + P + +PAVGQGA+GI CR D    R+LL   L+H  +     AERA   ++
Sbjct: 181 SLHIRDRIDPSLIVPAVGQGALGIACREDQDALRDLLRETLHHAPSGHAANAERAFLKKV 240

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
            GGCQVP+G++A + DG + L A + A DGS+  R ERR AP+D   +G  LA +LL  G
Sbjct: 241 GGGCQVPLGAWAHIDDGTLVLDACIAALDGSEHYRDERRCAPEDGAAVGRKLAADLLAMG 300

Query: 299 AREILAEV 306
              IL +V
Sbjct: 301 GDHILDDV 308


>UniRef50_A6GVP0 Hydroxymethylbilane synthase n=18 Tax=Bacteroidetes
           RepID=A6GVP0_FLAPJ
          Length = 308

 Score =  353 bits (906), Expect = 6e-96,   Method: Composition-based stats.
 Identities = 111/311 (35%), Positives = 174/311 (55%), Gaps = 8/311 (2%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M    ++I TR S LALWQAH+V+  L  +  G   +++ + ++GD+ILD PL ++G  G
Sbjct: 1   MAKKTIKIGTRDSELALWQAHHVEKML--NDLGHKTKIIAVKSQGDIILDKPLYELGITG 58

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           +F K L++A++    DIAVHSMKDVP   PQG+    + ER + +D  V NN  +LD L 
Sbjct: 59  IFTKTLDIAMVNGDIDIAVHSMKDVPTALPQGIVQAAVLERANEKDILVYNN--NLDFLN 116

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
             + + T SLRRQ Q   + P+  +  LRGNV TR+ KL +  ++  + A AGL+R+ ++
Sbjct: 117 TQATIATGSLRRQAQWLHKYPNHKVVDLRGNVNTRMQKLQDNNWNGAVFAAAGLERINIK 176

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
                 +  +  +PA  QGA+ +    +D+   + LA LNH ET +    ER     LEG
Sbjct: 177 PE--NYINLDWMIPAPAQGAMMVVAMGNDTYCLDALAELNHIETEITTYIERQFLRTLEG 234

Query: 241 GCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
           GC  PIG+YA     D  I  + ++ + DGSQ I  ++    Q+ +Q+G    +E+  NG
Sbjct: 235 GCTAPIGAYARFNEKDETIHFQGVLFSLDGSQKIEIKKIVEIQEWKQLGYHAGQEIFENG 294

Query: 299 AREILAEVYNG 309
             +++  +   
Sbjct: 295 GVQLMKTIKEK 305


>UniRef50_C6WZF5 Porphobilinogen deaminase n=1 Tax=Flavobacteriaceae bacterium
           3519-10 RepID=C6WZF5_FLAB3
          Length = 311

 Score =  352 bits (905), Expect = 7e-96,   Method: Composition-based stats.
 Identities = 107/307 (34%), Positives = 172/307 (56%), Gaps = 7/307 (2%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             ++I TR SPLALWQA  V   L  +      ++ P++++GD  L  PL  +G  G+F 
Sbjct: 10  RSIKIGTRNSPLALWQAREVARHLQNN--NHTTDITPIISKGDKNLSQPLYTLGITGIFT 67

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           K+L++ALL N  DIAVHS+KD+P + P+ + ++ + +R+ P+D  V     +   L    
Sbjct: 68  KDLDIALLNNEVDIAVHSLKDIPTQLPENVEIIAVLQRDYPQDVLVRKKDAATLELHQ-L 126

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            + TSSLRR+    +  P      +RGNV TRL+KL+  ++DA + ++A ++R+GL    
Sbjct: 127 KIATSSLRRRAFWLKEFPGTEFSDIRGNVQTRLTKLEENDFDATMFSLAAIERMGLSVD- 185

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
                  + +PA  QG V +  R +D   +EL   +NH ET + +  ER+  + LEGGC 
Sbjct: 186 --YEHLPLMIPAPAQGVVAVCARSNDPEIKELFKEINHRETRICIDIERSFLSTLEGGCT 243

Query: 244 VPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302
            PIG++AE+ D GE+     + + DG   I  +   A  + +  G  LAE++L NG RE+
Sbjct: 244 APIGAFAEINDLGEVRFTGRICSLDGQNCIETDEIFAWNEHDDFGKILAEKILQNGGREL 303

Query: 303 LAEVYNG 309
           + E+ + 
Sbjct: 304 MQEIKSK 310


>UniRef50_A8U3E9 Porphobilinogen deaminase n=1 Tax=alpha proteobacterium BAL199
           RepID=A8U3E9_9PROT
          Length = 321

 Score =  352 bits (903), Expect = 1e-95,   Method: Composition-based stats.
 Identities = 131/306 (42%), Positives = 178/306 (58%), Gaps = 7/306 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLV--VELVPMVTRGDVILDTPLAKVGGKGLFV 63
           L + +R SPLAL Q H V+D+L A+ P L   + +  + T GD + D PLA++GGKGLF+
Sbjct: 15  LTLGSRGSPLALRQTHEVRDRLAAAWPELAGAIAVQEIRTTGDAVRDRPLAEIGGKGLFI 74

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KE+E AL+  + D AVHSMKD+         LV +  REDPRDA++S   D +D LP+G+
Sbjct: 75  KEIEQALMAGQIDAAVHSMKDMETTIAPASVLVAVLPREDPRDAWLSPIADRVDDLPSGA 134

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            +GT+S+RR  Q+  RRPDL +   RGNV TRL KL  GE     LA AGL RLG+  + 
Sbjct: 135 KIGTASVRRAAQVLNRRPDLQVVLFRGNVDTRLRKLAEGEVAGTFLAAAGLSRLGMLDKA 194

Query: 184 RAALPPEISLPAVGQGAVGIECR-----LDDSRTRELLAALNHHETALRVTAERAMNTRL 238
              L  +  LPAV QGA+G++CR       D+  R  L+ L+   + LRVTAERAM   L
Sbjct: 195 TRILEVDEMLPAVSQGAIGVQCRDGEASARDAEIRNWLSILDDRPSRLRVTAERAMLATL 254

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
           +G C+ PI  +A L    + L  +V + DG          A  D E +G ++ E +L  G
Sbjct: 255 DGSCRTPIAGHATLGGARLTLSGMVFSLDGQSSHGAVDTSATDDPEALGRTVGEAILARG 314

Query: 299 AREILA 304
            R  LA
Sbjct: 315 GRNFLA 320


>UniRef50_C7N5L0 Porphobilinogen deaminase n=2 Tax=Slackia RepID=C7N5L0_SLAHD
          Length = 318

 Score =  351 bits (902), Expect = 2e-95,   Method: Composition-based stats.
 Identities = 121/313 (38%), Positives = 167/313 (53%), Gaps = 5/313 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +     I TR S LALWQ   V   +M + P + VE+    T GD+ L +PLA++G KGL
Sbjct: 1   MPERFVIGTRGSKLALWQTETVGRAIMRAFPEIEVEIRVRNTTGDINLASPLAEIGDKGL 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDA 118
           F +ELE  LL    D+ VHS+KD+  E P+G  +  +  R D RD  V        SL  
Sbjct: 61  FTRELETDLLLGEVDMCVHSLKDLETEQPEGCVVAGVLPRADARDVLVCGPRIQAASLAE 120

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178
           +P GS +GT S RR  QL    P+++   +RGNV TR++K +  +Y+  ILA AG+KR+G
Sbjct: 121 VPEGSRIGTGSRRRVAQLKANFPNMVPEGIRGNVDTRVAKAEGDDYEGAILAAAGMKRMG 180

Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
            E  I A LP E  +PA GQGA+ +E    + R  ++  ALN   T     AER +   L
Sbjct: 181 YEDHIAAYLPIEDMIPAPGQGAIAMEVLKKNERAYQIARALNDPVTKACTDAERFVLFSL 240

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ--DAEQMGISLAEELLN 296
           EGGC  PIG++  L DG+    A V +  G++  R          D   M   +  EL+ 
Sbjct: 241 EGGCSAPIGAHCRLEDGKYIFDACVLSLGGTKAARCHLEADADSADPMDMAWEVVSELIG 300

Query: 297 NGAREILAEVYNG 309
            GAR IL ++ NG
Sbjct: 301 EGARAILRDIKNG 313


>UniRef50_Q11XT5 Porphobilinogen deaminase n=8 Tax=Bacteria RepID=HEM3_CYTH3
          Length = 312

 Score =  350 bits (899), Expect = 3e-95,   Method: Composition-based stats.
 Identities = 125/310 (40%), Positives = 172/310 (55%), Gaps = 4/310 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           ++  +RI TR S LALWQA +V   L     GL  ++V + T GD ILD  L+K+G KGL
Sbjct: 1   MNKTVRIGTRGSKLALWQAEHVAACLQTK--GLEPQIVIIDTTGDKILDQSLSKIGSKGL 58

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F +ELE  L     DIAVHS KD+      G+ ++ I ERE   D  VS+          
Sbjct: 59  FTEELEEQLHAGTIDIAVHSAKDLQTHLKGGMYILAITERELVNDVLVSHKPIDTLKNNP 118

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
             I+GTSS RR+  L +  P   +  +RGN+ TR+ K++ G  DA++LA AG+ R+G +S
Sbjct: 119 DLIIGTSSTRRRALLRKFYPQAKMVDMRGNLQTRIRKMEEGACDAMLLAYAGMHRMGYDS 178

Query: 182 RIRAALPPEISLPAVGQGAVGIECRL--DDSRTRELLAALNHHETALRVTAERAMNTRLE 239
            I+  L  E  +PA GQG + IE     D  +   + A LN   T   V+AERA    LE
Sbjct: 179 LIKEKLSLEEFIPAAGQGTLAIEAASTLDKEKAAVIRAVLNDAATETAVSAERAFLRTLE 238

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
           GGC +P+ + A   D +  L   + + DG++ +R E R    DAEQ G+ LA  LL +GA
Sbjct: 239 GGCSIPVFALAVERDTDYLLTGGIVSLDGTKYLRKEIRFTAADAEQRGVELATVLLKDGA 298

Query: 300 REILAEVYNG 309
            EILAE+  G
Sbjct: 299 DEILAEIKKG 308


>UniRef50_A6DBT5 Porphobilinogen deaminase n=1 Tax=Caminibacter mediatlanticus TB-2
           RepID=A6DBT5_9PROT
          Length = 295

 Score =  350 bits (899), Expect = 3e-95,   Method: Composition-based stats.
 Identities = 132/295 (44%), Positives = 178/295 (60%), Gaps = 8/295 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L IATR S LALWQA +VK +L   + G  V+L  + T GD ILD PLA +GGKGLF+KE
Sbjct: 3   LTIATRGSKLALWQAEWVKKRLE--NLGHEVDLKIVTTTGDKILDKPLASIGGKGLFIKE 60

Query: 66  LEVALLENRADIAVHSMKDVPVEF-PQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           +E ALL   A IAVHS+KD P E+  +   L  + +RE   D F+S  +++L  LP  ++
Sbjct: 61  VEEALLRGEAQIAVHSLKDFPTEYNKEHFTLAAVPKREAVEDVFLSETFETLAELPHNAV 120

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL--ESR 182
           VGTSS+RR  QL   R DL+I  LRGNV TR++KL  GEYDAIILA AG+KRL L  E +
Sbjct: 121 VGTSSIRRAMQLKAFREDLVISDLRGNVDTRINKLKKGEYDAIILAYAGVKRLNLIKEVK 180

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
               L  +I +PA+GQGA+GIE  + D +  E +  LN   T + VT ER     L  GC
Sbjct: 181 YFEILDTDIMIPAMGQGALGIET-IKDEKVIEAVKPLNDLWTKIEVTIERDFIDELNLGC 239

Query: 243 QVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
             P+G  A++ +D  I ++A +   + +++I+ E      + E  G   AEE   
Sbjct: 240 HAPVGVNAKIMVDDSIKIKAAILDKN-NKVIKKEMVVPFDEWENAGREFAEEFKE 293


>UniRef50_A9FDP9 Porphobilinogen deaminase n=1 Tax=Sorangium cellulosum 'So ce 56'
           RepID=HEM3_SORC5
          Length = 300

 Score =  350 bits (899), Expect = 4e-95,   Method: Composition-based stats.
 Identities = 152/299 (50%), Positives = 196/299 (65%), Gaps = 4/299 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   L +ATR+S LAL Q+      L A+ P L +  + +VT GD   D  L  +GGKGL
Sbjct: 1   MPTELTLATRRSALALAQSRAFARSLEAAVPDLSLRELEVVTSGDKTQDRSLQDIGGKGL 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F+KELE ALL+ RAD AVHS+KDVP E    L L  I  REDPRDA V+ +   L  LPA
Sbjct: 61  FIKELEEALLDRRADFAVHSIKDVPAEIAPALCLACIPAREDPRDALVTRSGALLAELPA 120

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ VGTSSLRR   L E RPDL+I  +RGNV TRL K+ +G +DA++LA+AGLKRLGLE+
Sbjct: 121 GARVGTSSLRRAVALREARPDLVIEPVRGNVDTRLRKVFDGVFDAVVLALAGLKRLGLEA 180

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
           R    L PE+SLPA+GQGA+GIECR  D   R++L  L   ET + V+AERA+   +EG 
Sbjct: 181 RATEVLSPEVSLPAIGQGALGIECRTADDSVRDVLGTLADAETTICVSAERAVMAAVEGS 240

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR----GAPQDAEQMGISLAEELLN 296
           C+ P+ +YA    G +WLRAL+  PDGS++ R ERR    G  ++AE++G  L  EL  
Sbjct: 241 CRTPVAAYAVRDGGALWLRALLAEPDGSRLRRAERRLSWPGNTREAERLGADLGAELKK 299


>UniRef50_A6GB01 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=A6GB01_9DELT
          Length = 322

 Score =  349 bits (896), Expect = 8e-95,   Method: Composition-based stats.
 Identities = 138/309 (44%), Positives = 182/309 (58%), Gaps = 6/309 (1%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
             LR+ TR S LALWQA+ ++D+L+A+    GL VELV +VT+GD + D PL +VGG GL
Sbjct: 9   RKLRLGTRGSALALWQANMIRDRLLAAWGAQGLEVELVRVVTKGDRVTDRPLNQVGGMGL 68

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD--SLDAL 119
           FVK LE  LL    D AVHSMKD+P   P+GL L +  ER DPRDAF++      +L  L
Sbjct: 69  FVKGLEDKLLAGEIDFAVHSMKDMPGTLPEGLTLASTPERADPRDAFLAAPGRDVTLATL 128

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179
           PAGS +GTSSLRR        P L I  +RGNV TR+ K+  GE DA++LA AGL RLG 
Sbjct: 129 PAGSRLGTSSLRRGALAKRINPGLEIVPIRGNVPTRMGKIAEGEVDAVLLAAAGLDRLGK 188

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
              I   L P+  +PA  QG + IE R  D+    L   L H  T++   AER+    L+
Sbjct: 189 GEAITERLDPDAFMPAACQGVLAIELRAADTDIAALFEPLGHGPTSIVAAAERSYLATLQ 248

Query: 240 GGCQVPIGSYAELIDG--EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           GGCQVP+  +A L +    + +  LV  PDGS +   E  G   DA Q+G  +A E+L  
Sbjct: 249 GGCQVPLACHARLSEDGRRVRVEGLVVEPDGSTVYASEAEGPVADAAQLGAGVAREVLAA 308

Query: 298 GAREILAEV 306
           G + ++  +
Sbjct: 309 GGQGVIDRL 317


>UniRef50_C4Z552 Porphobilinogen deaminase n=8 Tax=Bacteria RepID=HEM3_EUBE2
          Length = 295

 Score =  349 bits (895), Expect = 1e-94,   Method: Composition-based stats.
 Identities = 122/291 (41%), Positives = 166/291 (57%), Gaps = 5/291 (1%)

Query: 7   RIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66
           RI TR S LAL Q+ YVK ++  ++P    ELV + T GD + D PLA +G KG FVKE+
Sbjct: 4   RIGTRGSKLALVQSEYVKRRMEEAYPEDTFELVIIKTTGDKVTDKPLAAIGTKGFFVKEI 63

Query: 67  EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126
           E ALL    D+AVHSMKD+P E   GL      +RED RD  +     S   LP+G+++G
Sbjct: 64  EEALLSGSIDMAVHSMKDMPAECAAGLTFAKAWKREDCRDVLILKTAGSFSELPSGAVIG 123

Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY--DAIILAVAGLKRLGLESRIR 184
           T SLRR CQLA  RPD+   ++RGNV TR++KL +  Y  D I+LA AGL RLG  S I 
Sbjct: 124 TGSLRRACQLAMLRPDIQFTAIRGNVDTRINKLMDDSYGLDGIVLAAAGLNRLGRSSEIT 183

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L PE+ +PA  QG + IE    ++   + + AL+   +     AER       GGC  
Sbjct: 184 EYLDPEVVIPAPAQGVLAIETAEVNTELLDKINALSDDNSDREAVAERTFLRLTGGGCHA 243

Query: 245 PIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
           P+G++     +G++ +  L G  D S+I+R E  G   D+E +G   A  L
Sbjct: 244 PVGAHCVTKDNGDLRMVVLFGNDDCSRILRIEVTGT--DSEAVGHEAARML 292


>UniRef50_C0YV01 Hydroxymethylbilane synthase n=1 Tax=Chryseobacterium gleum ATCC
           35910 RepID=C0YV01_9FLAO
          Length = 302

 Score =  347 bits (892), Expect = 3e-94,   Method: Composition-based stats.
 Identities = 108/305 (35%), Positives = 166/305 (54%), Gaps = 6/305 (1%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             +RI TR S LALWQA  V   L  +    + E+VP+V+ GD  L+ PL  +G  G+F 
Sbjct: 2   KSIRIGTRNSALALWQAREVARHLQNN--NYLTEIVPIVSSGDKNLNQPLYSLGITGVFT 59

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           ++L++ALL +  DIAVHS+KDVP + PQ + ++   ER+ P+D  +              
Sbjct: 60  RDLDIALLNDEIDIAVHSLKDVPTQLPQNIEMIAYLERDYPQDILIRKESSRNKEFHE-L 118

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            + TSSLRR+       P      +RGN+ TRL KL+ G++DA IL++AG+KR+ +E   
Sbjct: 119 KLATSSLRRRAFWLRNYPTAEFSDIRGNIQTRLQKLEEGDFDATILSLAGIKRMKMEID- 177

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
                  + + A  QG + +    D     E++  +NH ET + V  ER   + LEGGC 
Sbjct: 178 --YEMLPLMISAPSQGVISVAGHTDKPEINEIVRQINHQETQICVEIERNFLSTLEGGCT 235

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
            PIG++AE+I  +I  +A + + DG   I  +       AE  G   A+ +L NG +E++
Sbjct: 236 APIGAFAEIIGDQIRFKAALCSLDGKNCIAVDENFVYTPAENFGEKYAKVVLENGGKELM 295

Query: 304 AEVYN 308
           AE+ +
Sbjct: 296 AEIKS 300


>UniRef50_A3CL78 Porphobilinogen deaminase n=1 Tax=Streptococcus sanguinis SK36
           RepID=HEM3_STRSV
          Length = 306

 Score =  346 bits (889), Expect = 5e-94,   Method: Composition-based stats.
 Identities = 126/300 (42%), Positives = 179/300 (59%), Gaps = 7/300 (2%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
            V+++ TR+S LA+ Q   + D+L A HP     LVP  T+GD +    L ++GGKG+FV
Sbjct: 2   KVIKVGTRKSKLAMTQTQQLVDQLKALHPERDFVLVPYTTKGDRLTHVSLQEIGGKGVFV 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALPAG 122
           KE+E ALL    ++AVHS+KD+P +  +G  L  I +RED RD  +      +L  LP G
Sbjct: 62  KEIERALLAGEINMAVHSLKDMPAKLAEGCALGAISQREDVRDCLIFRQAGQTLADLPKG 121

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           S++GTSS+RRQ QL  +RPDL  + LRGN+ TR+ KL+ GEYDAI+LA+AGLKRLG   +
Sbjct: 122 SLIGTSSIRRQVQLQAQRPDLAFKPLRGNIDTRIKKLEEGEYDAIVLAMAGLKRLGWLDQ 181

Query: 183 IR---AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
            R     L   + LPA+ QGA+ +ECR +D     LLAA+   +TA  V  ERA+  ++ 
Sbjct: 182 SRLHIQPLETSLCLPAISQGALAVECREEDEELLSLLAAVQDEKTAAEVAVERAVLAQMN 241

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
             C  PI ++A+       L A++   DG Q I    +G  QD +Q+      +L + GA
Sbjct: 242 ADCTFPIAAFAQKNGQGYQLEAMLAKEDG-QCIFVSLQG--QDGQQLAEQAVRQLADKGA 298


>UniRef50_C3PNS9 Porphobilinogen deaminase n=15 Tax=Rickettsia RepID=HEM3_RICAE
          Length = 351

 Score =  345 bits (887), Expect = 9e-94,   Method: Composition-based stats.
 Identities = 105/254 (41%), Positives = 156/254 (61%), Gaps = 1/254 (0%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           + N +RI TR+SPLAL   + V  ++    P +  E+VP++T GD+I + PL  +GGK L
Sbjct: 1   MTNSIRIGTRKSPLALIHTNLVIQQIKQFFPDINCEIVPIITSGDLIQNKPLYDIGGKAL 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F+KE+E ALL+ + D+AVHS+KDVP   P+ L +  + EREDPRD FV   Y S++ LP 
Sbjct: 61  FLKEIEQALLDKKIDLAVHSLKDVPGRIPEPLVIAAVLEREDPRDVFVCLKYKSIEELPQ 120

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL-E 180
            +++G+S++RR+  + + RPDL +   RGNV +R+ KL  GE DA ILA  GLKRL +  
Sbjct: 121 NAVIGSSAVRRKAFIQKIRPDLKVTVFRGNVDSRIKKLMTGEVDATILAYTGLKRLEVFN 180

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
                 +     LP +GQG + +E R DD+   E+   +NH  T   +  ERA    L+ 
Sbjct: 181 PEYCHLIEYSQMLPCIGQGVIAVEIRKDDNAMLEICNQINHLPTFELIKPERAFLEYLDA 240

Query: 241 GCQVPIGSYAELID 254
            C+ PI +Y++ +D
Sbjct: 241 NCRTPIAAYSQYLD 254


>UniRef50_D0NJW2 Porphobilinogen deaminase n=2 Tax=Phytophthora infestans T30-4
           RepID=D0NJW2_PHYIN
          Length = 361

 Score =  345 bits (886), Expect = 1e-93,   Method: Composition-based stats.
 Identities = 124/320 (38%), Positives = 173/320 (54%), Gaps = 11/320 (3%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGK--- 59
              + +++R+S LA+ Q + V   L    P L   +    T GD +LD  L+ +G     
Sbjct: 13  KRTIFVSSRKSQLAMAQTNTVIAMLEERFPDLQFVVGQEDTVGDQVLDRHLSDLGTTTAS 72

Query: 60  GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS------NNY 113
           GLF K LE ALL   A  AVHS+KD+P   P GL L  I +RE P DA V          
Sbjct: 73  GLFTKSLEEALLAKAASFAVHSLKDMPTTLPDGLVLAAITKRESPEDAAVIHPKHKEKGI 132

Query: 114 DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVA 172
            +L  LP GS++GTSSLRR+  L  + P   I+++RGN+ TRL+KLD   +YDAII+A  
Sbjct: 133 KTLQELPEGSVIGTSSLRREALLRSQFPTFEIKTVRGNIQTRLAKLDEHDDYDAIIVAAC 192

Query: 173 GLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232
           G +R  L  RI   LP +     VGQG++G+ECR DD  T E+L  +   ++A    AER
Sbjct: 193 GFRRGELGDRIDEILPMDTFGYGVGQGSIGVECRADDEETIEMLKTITDEKSAQLCKAER 252

Query: 233 AMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAE 292
           ++   LEGGCQ+ +G  A L +  + L A V + DG + +     G     E++G  LAE
Sbjct: 253 SLLYHLEGGCQIAMGVSATLDEDTLTLNATVLSRDGKESVHETISGPRTQCEELGKQLAE 312

Query: 293 ELLNNG-AREILAEVYNGDA 311
              NN  AR++L +     A
Sbjct: 313 RFWNNELARKVLGKTRQKRA 332


>UniRef50_B3U3W9 Hydroxymethylbilane synthetase n=1 Tax=Oxyrrhis marina
           RepID=B3U3W9_OXYMA
          Length = 395

 Score =  345 bits (885), Expect = 1e-93,   Method: Composition-based stats.
 Identities = 129/303 (42%), Positives = 169/303 (55%), Gaps = 3/303 (0%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMAS-HPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           LRI TR SPLAL QA  V+ +       G  +++  + T GD ILD  LA VGGKGLF K
Sbjct: 76  LRIGTRGSPLALAQARDVESRAREQLQQGGEIDICVISTEGDRILDRALADVGGKGLFTK 135

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           EL+ ALL    D  VHSMKDVP     G  +V    RED RD F+S  Y +L  LP G++
Sbjct: 136 ELDRALLSGEVDCCVHSMKDVPTTVAPGTEIVAYLPREDTRDVFLSAKYATLADLPDGAV 195

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGT+SLRRQ Q+  ++ ++++ + RGNV TRL KL  G  D   LA AGLKRLG+ +   
Sbjct: 196 VGTASLRRQAQILAQK-NVVVTNFRGNVQTRLRKLAAGTVDCTFLAYAGLKRLGMLAEAT 254

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L     LPA+ QGAVGI+ R +D+  R  L+ L+H  T L V  ERA    L+G C+ 
Sbjct: 255 QVLEWSDMLPAIAQGAVGIQIRSNDAALRGTLSQLDHEPTRLAVETERAFLRALDGSCRT 314

Query: 245 PIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           PI   A +  D  +  R  V + DG Q         P D  ++G +L ++L      E  
Sbjct: 315 PIAGQAWIGPDSRLAFRGQVLSADGKQRFERVGDCLPCDGPELGKTLGDDLRREAGEEFF 374

Query: 304 AEV 306
           AE+
Sbjct: 375 AEL 377


>UniRef50_B2W5W6 Porphobilinogen deaminase n=2 Tax=Pleosporineae RepID=B2W5W6_PYRTR
          Length = 399

 Score =  343 bits (882), Expect = 3e-93,   Method: Composition-based stats.
 Identities = 129/348 (37%), Positives = 177/348 (50%), Gaps = 45/348 (12%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG----KG 60
            + I TR S LA  QA  V+  L  ++P     + P++ +GD    TPL ++      K 
Sbjct: 30  PVNIGTRNSVLAQIQARAVERSLKDAYPERTYNICPVIVQGDRDKITPLQQLSQGENAKS 89

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS----NNYDSL 116
           L+  ELE  L     DI VH +KD+P + P  L L  I EREDPRDA +         +L
Sbjct: 90  LWTGELESMLESGDLDIIVHCLKDMPTQLPDHLELGAILEREDPRDALLVSPRLPKETTL 149

Query: 117 DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAGL 174
             LP G+ +GTSS+RR   L +  P L    LRGNVGTRL+KLD  +  Y AIILA AGL
Sbjct: 150 ATLPQGATIGTSSVRRAATLRKLYPHLKFADLRGNVGTRLAKLDAEDSPYSAIILAAAGL 209

Query: 175 KRLGLESRIRAALPPEI--SLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232
           KR+GL++RI   L       L AVGQGA+GIE R +D   +EL++ +    T    +AER
Sbjct: 210 KRMGLDNRITQYLSSTSGGMLHAVGQGALGIEIRKNDEAMKELMSKIRCERTTRACSAER 269

Query: 233 AMNTRLEGGCQVPIGSYAELIDG------------------------------EIWLRAL 262
           A+   LEGGC VPIG       G                              E+ +RA+
Sbjct: 270 ALLRTLEGGCSVPIGVETSWKGGKGLSVGPQPAKDYDKHGNAVEEDEPDVDDQELVMRAM 329

Query: 263 VGAPDGSQIIRGERR---GAPQDAEQMGISLAEELLNNGAREILAEVY 307
           V + DG + +  E        ++AE+MG  +A+ L+  GA +IL ++ 
Sbjct: 330 VVSVDGKESVEYEATRKVRNAEEAEEMGREVAKILIEKGADKILEKIN 377


>UniRef50_UPI00006CBE06 porphobilinogen deaminase family protein n=1 Tax=Tetrahymena
           thermophila RepID=UPI00006CBE06
          Length = 362

 Score =  343 bits (881), Expect = 4e-93,   Method: Composition-based stats.
 Identities = 125/339 (36%), Positives = 181/339 (53%), Gaps = 32/339 (9%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLM-ASHPGLV---VELVPM--------------- 41
           + +   +IA+R S LAL Q + V D L+     GL     E+VP+               
Sbjct: 16  LKNRKFKIASRSSQLALSQTYEVIDLLVGVKELGLTKENFEVVPISNAPGKNCTLKFKIN 75

Query: 42  ------VTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGL 95
                   +GD  L  PL  +GG G+F K +EV LL    DIAVHS+KD+P    + L +
Sbjct: 76  ITNKQFTNKGDQNLKDPLYVMGGVGVFTKIVEVELLNKNGDIAVHSLKDLPTIIDERLFI 135

Query: 96  VTICEREDPRDAFVS---NNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNV 152
             +   +   D  +    +    L  LP GS++GTSSLRR   L  R P L   ++RGN+
Sbjct: 136 GAVPPLKPRGDVVIFNEKHKGKELKDLPEGSVIGTSSLRRITNLKNRYPHLKYENIRGNL 195

Query: 153 GTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRT 212
            TRL+KL+NG+YDAIILA AG+ RLG   ++   L  E  L A GQGA+G++CR DD   
Sbjct: 196 NTRLTKLENGQYDAIILAEAGVFRLGWIEKVGQFLKQEDFLYAPGQGALGVQCRADDKEA 255

Query: 213 RELLAALNHHETALRVTAERAMNTRLEG---GCQVPIGSYAELIDGEIWLRALVGAPDGS 269
             LL+ +N  E  +RV AER    +LEG   GC++PI  ++E+ID  + L   V + +  
Sbjct: 256 IALLSYINQKEPRIRVDAERQFLNKLEGVILGCKLPIAVHSEIIDQTLRLTGQVWSLEAD 315

Query: 270 QIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYN 308
           + IR    G   D + +G+ L+E++   GA EIL ++ +
Sbjct: 316 KTIREVIEGHISD-QDLGLKLSEKMKQAGAGEILEKIRS 353


>UniRef50_Q1V167 Hydroxymethylbilane synthase n=3 Tax=Candidatus Pelagibacter
           RepID=Q1V167_PELUB
          Length = 307

 Score =  343 bits (881), Expect = 4e-93,   Method: Composition-based stats.
 Identities = 111/300 (37%), Positives = 168/300 (56%), Gaps = 3/300 (1%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVE---LVPMVTRGDVILDTPLAKVG 57
           M +  + I +R S LAL  A   ++K++       +E   +  +VT+GD + D  L++VG
Sbjct: 1   MKNRKIIIGSRGSKLALIYAEKAREKILKHSKDFGIEEVIIKEIVTKGDQVQDKRLSEVG 60

Query: 58  GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD 117
           GKGLF K +EV LLE + DIAVH++KD+P E  +GL      ER DPR+  +S +   L 
Sbjct: 61  GKGLFSKTIEVELLEKKIDIAVHALKDMPSEETRGLLTDCFLERNDPREILISKDNKHLK 120

Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177
            L + SI+GTSS RR+ Q+ + R DL  + +RGNV TR+ KL    YDAIIL+ AG+  L
Sbjct: 121 DLASNSIIGTSSYRREFQIKKIRDDLNCKLIRGNVDTRIRKLKENLYDAIILSYAGIDSL 180

Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237
           GL   I         +P  GQG + ++CR +D    ELL  ++H  T   + AER +   
Sbjct: 181 GLNQNISQTFSTSEIIPCAGQGVIALQCRDNDESLIELLKQVDHQSTHSSIKAERNVLKV 240

Query: 238 LEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           LEG C+  +G++A +   +I L   + + DGS+    +   +   AE++GI + + L   
Sbjct: 241 LEGDCETAVGAFANIEGNKINLEVELFSLDGSKRFYLKSSESVDKAEELGIEMGKTLKKM 300


>UniRef50_A3ZKX4 Porphobilinogen deaminase n=1 Tax=Blastopirellula marina DSM 3645
           RepID=A3ZKX4_9PLAN
          Length = 308

 Score =  343 bits (880), Expect = 5e-93,   Method: Composition-based stats.
 Identities = 133/302 (44%), Positives = 184/302 (60%), Gaps = 5/302 (1%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            +RI TR S LA WQA++V D+L A   G  VE++ + T+GDV    PL  +GG+G+F  
Sbjct: 3   AIRIGTRGSQLAQWQANWVADQLRAV--GTDVEIIHIATQGDVTQ-GPLDLIGGRGVFTT 59

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           E++ ALL+NR D+AVHS+KD+P E   GL L  +  R    D  +++    +  LP  SI
Sbjct: 60  EIQAALLDNRIDVAVHSLKDLPTEAVVGLRLAAVPARGADGDVLITSKASDVLGLPQESI 119

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GT S+RR+ QL   R D  IR +RGN+ TRL KLD+G YDAIILA AGL+RL L  RIR
Sbjct: 120 IGTGSMRRKAQLLHLRRDFQIRDIRGNLDTRLRKLDDGLYDAIILAEAGLRRLELIERIR 179

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             +P    LPAVGQGA+G+E R  DS T  +LA LNH ++   V AER+M   L GGC  
Sbjct: 180 HVIPKAQMLPAVGQGALGLEIRERDSATAAMLAPLNHEDSHYSVLAERSMLRNLRGGCLA 239

Query: 245 PIGSYAELI--DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302
           P+G++  +      ++L  +V + DG   +     G P  AE +G  +A++L   GA  +
Sbjct: 240 PVGAWGRIDPIKQLLFLDGVVVSGDGHHKVTASACGPPNRAEDIGRQVADQLAIQGAERL 299

Query: 303 LA 304
           +A
Sbjct: 300 IA 301


>UniRef50_C4ZFT9 Porphobilinogen deaminase n=1 Tax=Eubacterium rectale ATCC 33656
           RepID=C4ZFT9_EUBR3
          Length = 338

 Score =  342 bits (879), Expect = 8e-93,   Method: Composition-based stats.
 Identities = 113/309 (36%), Positives = 161/309 (52%), Gaps = 39/309 (12%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67
           I TR S LAL Q  YV DKL  ++P    + V + T GD+     L K+G KG+FVKE+E
Sbjct: 5   IGTRGSKLALVQTDYVIDKLKRAYPDDDFKAVIIKTTGDLEQKKALDKIGSKGIFVKEIE 64

Query: 68  VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127
             LL  +  +AVHSMKD+P E   GL      +REDPRD  V  N  SLD LP G+++GT
Sbjct: 65  DELLSGKIHMAVHSMKDMPDEPAAGLTFAKAWKREDPRDVLVLKNAASLDELPHGAVIGT 124

Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE------------------------ 163
            S RR+ QL + RPDL +  +RGN+ TRL KL +GE                        
Sbjct: 125 GSKRRKYQLLKLRPDLKVVGIRGNIDTRLRKLYDGEIIYEEVADNTVNNNEIANEKKNKY 184

Query: 164 ----YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAAL 219
                D I+LA AG+KR+G +S I      +  +PA  QG + +E R D+++    L AL
Sbjct: 185 SEYRLDGIVLAAAGIKRIGRDSEITQYFSEDDMIPAPAQGTLALELRADNAKLMAKLDAL 244

Query: 220 NHHETALRVTAERAMNTRLEGGCQVPIGSYAELI-----------DGEIWLRALVGAPDG 268
           +  +T L    ER    ++ G C +P+ +Y +++           +  + L A+ G+ DG
Sbjct: 245 SDEKTNLCAGIEREFLKQIGGNCHLPVAAYCDIVSEKDRGNDSNKNNRLKLLAMFGSEDG 304

Query: 269 SQIIRGERR 277
            Q+ R E+ 
Sbjct: 305 KQLARTEQV 313


>UniRef50_A8MDU3 Probable porphobilinogen deaminase n=2 Tax=Thermoproteaceae
           RepID=HEM3_CALMQ
          Length = 305

 Score =  342 bits (878), Expect = 9e-93,   Method: Composition-based stats.
 Identities = 124/304 (40%), Positives = 179/304 (58%), Gaps = 2/304 (0%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           ++RIATR S L+L Q   V D+++  +  +  +L+ + T GDV L  PL ++G KG+F +
Sbjct: 2   IIRIATRGSALSLKQTKIVMDRILEFNKDVEFKLIIVKTTGDVDLSKPLYEIGVKGIFER 61

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           E+  A+L   AD+AVHS+KD+P +    L LV    R++PRDA VS    ++D LP  SI
Sbjct: 62  EVNQAVLRGEADVAVHSLKDMPAQISNDLTLVMTPPRDNPRDALVSLRQYTVDTLPLNSI 121

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGTSSLRR+  L   R D+ ++ +RGNV TR+ KL+NGEYDA+I+A AGL+RL + + + 
Sbjct: 122 VGTSSLRRRGFLLSLRRDVTVKPIRGNVDTRIRKLNNGEYDALIMAAAGLERLSINANVS 181

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
               PE+  PA GQG +G+  R D     ++L   +  ET     AERA  +R+  GC V
Sbjct: 182 EI-SPELMPPAPGQGIIGVVARRDRDDLIKVLRRSSDEETFKEAAAERAFLSRIGAGCHV 240

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304
           P+G  A L DG       V  PDG +      R   ++ E+ G   AE+LL N AR ++A
Sbjct: 241 PLGGLALLDDGYFDFTYGVVDPDGVEKFINSTRIDARNPEEAGRVAAEDLLRN-ARGLVA 299

Query: 305 EVYN 308
            +  
Sbjct: 300 RLLK 303


>UniRef50_A0LRF1 Porphobilinogen deaminase n=1 Tax=Acidothermus cellulolyticus 11B
           RepID=HEM3_ACIC1
          Length = 331

 Score =  341 bits (876), Expect = 2e-92,   Method: Composition-based stats.
 Identities = 128/313 (40%), Positives = 165/313 (52%), Gaps = 6/313 (1%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           +VLR+ TR+S LA  Q   +   L A+  G  VE+V + + GD   D PL +  G G+FV
Sbjct: 8   SVLRLGTRRSTLARAQTEEIAGALRAA--GCRVEIVGIQSTGDRHADVPLHEFAGSGVFV 65

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
            EL  ALL    D+ VHSMKD+P      L +  I  R DPRDA V+     L  LP G+
Sbjct: 66  AELRAALLRGEVDVVVHSMKDLPTAEIPELAIAAIPRRADPRDALVTGAGCRLAELPTGA 125

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           IVGT S RR  QL   RPDL IR +RGN+ TRL KL  G Y A+I+A AGL RL      
Sbjct: 126 IVGTGSPRRAAQLRLLRPDLEIRPIRGNLDTRLGKLHAGGYAALIVAAAGLARLHRSEEA 185

Query: 184 RAALPPEISLPAVGQGAVGIECR----LDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
                P + LPA GQGA+ +ECR     D  R   +LA L+   T   VTAERA+   + 
Sbjct: 186 AEFFDPTVMLPAPGQGALAVECRRADIADGGRLAGILAGLDDPATRAAVTAERALLAAVG 245

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
            GC  P+G+   +    + L A+V  P G+   R    G P DA  +G  LA +L+  GA
Sbjct: 246 AGCSAPVGALGVVTADTLQLDAVVVDPSGTTAFRRSLTGTPDDASDLGRRLAADLIRAGA 305

Query: 300 REILAEVYNGDAP 312
            ++L        P
Sbjct: 306 DQLLQAPKQTGEP 318


>UniRef50_A2Q9P7 Catalytic activity: 4 porphobilinogen+H(2)O<=>hydroxymethylbilane+4
           NH(3) n=1 Tax=Aspergillus niger CBS 513.88
           RepID=A2Q9P7_ASPNC
          Length = 346

 Score =  341 bits (875), Expect = 2e-92,   Method: Composition-based stats.
 Identities = 121/324 (37%), Positives = 173/324 (53%), Gaps = 22/324 (6%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG-----KG 60
           LR+ TR S LAL QA +V  +L ++HPG+      +V RGD    +P  K  G     K 
Sbjct: 12  LRLGTRNSKLALVQAEHVSKELTSAHPGVQFPWQTVVVRGDADKSSPFLKFAGPSDAAKN 71

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-----YDS 115
           ++ +E+E  L     D+ VH +KD+P   P+   L  I  REDP DA V        Y  
Sbjct: 72  IWTEEMETKLCAGELDLLVHCLKDMPTRLPETCTLGAIVYREDPTDALVIKEGLRSQYTD 131

Query: 116 LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAG 173
           L  LP GS+VGTSS RR+  L  R P L +   RGN+GTRL KLD   G + AIILA AG
Sbjct: 132 LSQLPPGSVVGTSSTRRKALLRYRYPHLKVEECRGNLGTRLKKLDDPEGPFSAIILATAG 191

Query: 174 LKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERA 233
           + R+ LE RI   LPP     AVGQGA+GIE R +D++T+ ++  +    T     AER+
Sbjct: 192 MVRINLEDRITKRLPPSEFPYAVGQGALGIEIRKEDAQTKTMVRKIEDLVTRRICLAERS 251

Query: 234 MNTRLEGGCQVPIGSYAELID-------GEIWLRALVGAPDGSQIIRGERR---GAPQDA 283
           +   L+GGC  P+  +  +          ++ L   +  P G+ ++        G  +DA
Sbjct: 252 LLRTLQGGCSSPVAVHCTVEQAPTASSPAQLRLDGTIIHPHGTTLLSERTTAEVGTDEDA 311

Query: 284 EQMGISLAEELLNNGAREILAEVY 307
           E +G ++A++LL NG + +L E+ 
Sbjct: 312 EALGATVAQQLLKNGGQALLEEIR 335


>UniRef50_C1ZK04 Porphobilinogen deaminase n=1 Tax=Planctomyces limnophilus DSM 3776
           RepID=C1ZK04_PLALI
          Length = 318

 Score =  340 bits (873), Expect = 4e-92,   Method: Composition-based stats.
 Identities = 139/315 (44%), Positives = 181/315 (57%), Gaps = 16/315 (5%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           VLRIATR S LALWQA++V D L +  P L VELV + T GD +   PL + GG+G+F +
Sbjct: 3   VLRIATRASQLALWQANFVADSLRSLDPELTVELVHVTTTGDRVQGEPLRQFGGQGVFTR 62

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS----LDALP 120
           E++ ALLE RADIAVHS+KD+P     GL L  +  R    DA +     S    L  LP
Sbjct: 63  EVQAALLEGRADIAVHSLKDLPTVPTAGLELAAVPARAPVADALLLPTGHSGPASLAMLP 122

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ +GT S RRQ QL   RPDL+   +RGN+ TR+ KLD GEY+ +ILAVAGL RLG  
Sbjct: 123 RGARIGTGSPRRQAQLLRIRPDLVCSEVRGNLDTRIRKLDAGEYEGLILAVAGLSRLGWS 182

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            RI   L P    PA GQGA+G+ECR  D  T   ++ L   +T L V AERA+   LE 
Sbjct: 183 DRISLILAPPTMFPAAGQGALGLECRHGDEATIRWVSQLEDRQTRLAVDAERAVLRTLEA 242

Query: 241 GCQVPIGSYAELID-GEIWLRALVGAPDGSQIIRG--ERRGAPQD---------AEQMGI 288
           GC  P+G++A       + L A++ APDGS+ +      +G             A ++G 
Sbjct: 243 GCHAPVGTWASWKSPETLHLEAILIAPDGSETLAAASSMQGPLSQYGSGNALDAAHELGA 302

Query: 289 SLAEELLNNGAREIL 303
           ++A  LL  GA   L
Sbjct: 303 NVAHLLLKQGASRYL 317


>UniRef50_B8MVK7 Porphobilinogen deaminase, putative n=1 Tax=Talaromyces stipitatus
           ATCC 10500 RepID=B8MVK7_TALSN
          Length = 413

 Score =  339 bits (871), Expect = 6e-92,   Method: Composition-based stats.
 Identities = 124/337 (36%), Positives = 172/337 (51%), Gaps = 36/337 (10%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGL-VVELVPMVTRGDVILD---TPLAKVGG- 58
             +R+ +R S +AL Q   V   L  +H G     +     +GD         LAK  G 
Sbjct: 72  KAVRVGSRNSKMALIQTSSVAAALYKAHHGFFTFPVSTHSVQGDRDKTSAFRDLAKAHGN 131

Query: 59  --------KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS 110
                   K L+  E+E  LL    D+ VHS+KDVP   P G  +     R DP DA + 
Sbjct: 132 KQTAADTAKSLWTLEIEARLLAGDIDLIVHSLKDVPTTLPDGCEIGAFPHRNDPTDALLV 191

Query: 111 NN---YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YD 165
                Y SL+ LPAGS+VGT S+RR  QL    P LII+  RGNV TR++KLD  +  Y 
Sbjct: 192 KAGLPYKSLEELPAGSVVGTCSVRRTAQLRHYCPHLIIQECRGNVDTRVAKLDANDSPYT 251

Query: 166 AIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETA 225
           AI++A AG+ RL LE RI   L       AVGQGA+GIE R +D + REL+A ++H  T 
Sbjct: 252 AIVVAAAGIVRLNLEHRITQRLSGPAYTYAVGQGALGIEIRKEDQKARELVACIDHWPTR 311

Query: 226 LRVTAERAMNTRLEGGCQVPIGSYAELI---------------DGEIWLRALVGAPDGSQ 270
           +R  AERA+   L+GGC  PIG ++  +               +G ++L   +  PDG  
Sbjct: 312 VRCLAERALLRFLQGGCSAPIGVHSAFVRTPAKGEPNVNDNHYEGTLYLTGTLLHPDGGM 371

Query: 271 IIRGERRG---APQDAEQMGISLAEELLNNGAREILA 304
            IR   +G      D+E +G S+ +++L+ G  +IL 
Sbjct: 372 EIRAHEKGQVKCTADSETIGKSVGKKILDLGGAQILD 408


>UniRef50_A5CDH4 Porphobilinogen deaminase n=2 Tax=Orientia tsutsugamushi
           RepID=HEM3_ORITB
          Length = 298

 Score =  339 bits (871), Expect = 6e-92,   Method: Composition-based stats.
 Identities = 124/292 (42%), Positives = 161/292 (55%), Gaps = 3/292 (1%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           ++R+ +R S LAL QA  V  K+     GL   ++P+ T GD+I +  L  +GGKGLF+K
Sbjct: 2   IIRVGSRASRLALIQAQAVVQKINDL-LGLNAIIIPIKTTGDLIQNKNLYDIGGKGLFLK 60

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           E+E ALL N  DIAVHS+KDVP   P GL L  + ER D  D  VS   + +  LP G+I
Sbjct: 61  EIEYALLNNTIDIAVHSLKDVPAYLPDGLQLAAVLERGDVGDMLVSKIANKITDLPLGAI 120

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE-SRI 183
           VGTSS+RR+ QL   RPDL I   RGNV TR +K+ N E DA +LA AGL+RL  + SR 
Sbjct: 121 VGTSSVRRRIQLLMLRPDLNIVLFRGNVDTRWNKIINNEVDATVLAAAGLQRLNYDTSRF 180

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              +P    LPA+GQGA+ IE R DD     L A +NH  T   +  ER     L   C 
Sbjct: 181 CNIIPQSEMLPAIGQGAIAIEARKDDKLIMPLCAKINHQLTWQLIQVERGYLKTLNADCN 240

Query: 244 VPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
           VPIG  A  I       + ++G  +       E RG  Q    +G+  A+  
Sbjct: 241 VPIGGIASYIGNNSFEAKFMLGDYNMRYFFYSEVRGKLQHGYDIGVEAAKNF 292


>UniRef50_Q0TQG4 Porphobilinogen deaminase n=32 Tax=Clostridium RepID=HEM3_CLOP1
          Length = 291

 Score =  339 bits (870), Expect = 8e-92,   Method: Composition-based stats.
 Identities = 128/292 (43%), Positives = 170/292 (58%), Gaps = 4/292 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L IATR+S LA  Q   V + L      +  + + ++T GD  LD  L K+GGKGLFVKE
Sbjct: 3   LIIATRKSKLAQVQTEKVMELLKEKE-NVDSKKLLVMTEGDRRLDVSLNKIGGKGLFVKE 61

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E+ALL   A  AVHSMKDVP E P    LV + ERED RDAFVS N  +L  L  G+ +
Sbjct: 62  IELALLNKEAHGAVHSMKDVPFELPSEFELVAMPEREDIRDAFVSLNGSTLSNLRKGARI 121

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS+RR  QL   R DL I  +RGNV TR+ K+     D IILA AGLKRLG+E  I  
Sbjct: 122 GTSSIRRAEQLKLFRDDLEIVPIRGNVQTRIKKITEENLDGIILAAAGLKRLGMEDVISD 181

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
              P++ LPA+GQGA+GIEC        +   AL+  E    V AER+    L GGC   
Sbjct: 182 YFDPKVFLPAIGQGALGIECLKGG-EFNDYFKALDSKEVRTTVEAERSFMKVLNGGCHSL 240

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           IG+Y+E+ D ++++         ++I++ +  G  +D   +G  LAE++L  
Sbjct: 241 IGAYSEVKDNDLYMIGTFTV--NNRIVKKDILGNKEDNILLGKKLAEKILGE 290


>UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia (class)
           RepID=B9L0Q4_THERP
          Length = 560

 Score =  338 bits (868), Expect = 1e-91,   Method: Composition-based stats.
 Identities = 125/295 (42%), Positives = 163/295 (55%), Gaps = 4/295 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   +RI +R S LAL Q   V ++L    P   V +VP+VT GD    T L  +GG G+
Sbjct: 1   MAARIRIGSRGSTLALAQTEEVVERLRRLVPECSVTVVPIVTTGDRDRATSLTVLGGSGV 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F KEL  ALL    D+AVHS KD+P + P GL LV +  RED RD  V++    L  LPA
Sbjct: 61  FAKELHEALLAGTIDLAVHSAKDLPTQLPPGLVLVAVLAREDARDVLVTSPPRKLGELPA 120

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ VGTSS RRQ  L   RPDLI+  +RGNV TRL KL  G  DA++L  AGL+RL    
Sbjct: 121 GARVGTSSRRRQALLQRARPDLIVVDIRGNVDTRLRKLREGIVDALVLGAAGLRRLSQAD 180

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
            +   L P+  +PA GQGA+ +  R  D R  ELL+ L+       V  ERA       G
Sbjct: 181 LVAEYLDPDEFVPAPGQGALAVVARESDGRL-ELLSRLDEPLVHEAVAVERAFLAAFGSG 239

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDG---SQIIRGERRGAPQDAEQMGISLAEE 293
           C VP+G+YA +    +  R  V  PDG   SQ +   R  A + A ++G++LA  
Sbjct: 240 CSVPLGAYATIAGNRLRFRIAVLLPDGRFISQCLDWPREEAIERARELGLTLATR 294


>UniRef50_B5G8F1 Porphobilinogen deaminase n=1 Tax=Streptomyces sp. SPB74
           RepID=B5G8F1_9ACTO
          Length = 314

 Score =  338 bits (867), Expect = 2e-91,   Method: Composition-based stats.
 Identities = 128/314 (40%), Positives = 172/314 (54%), Gaps = 13/314 (4%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR SPLAL Q   V   L    P L +E+VP+ T+ D      LA++GGKGLFV+E
Sbjct: 1   MRIGTRSSPLALAQVEQVSGLLRKFEPDLDIEVVPVTTKADKWQGD-LAQLGGKGLFVRE 59

Query: 66  LEVALLENRADIAVHSMKDVP--VEFPQGLGLVTICEREDPRDAFVSNNY---DSLDALP 120
           ++  L   + D+AVH MKDVP  V  P+GL       R+D RD  +        SL  LP
Sbjct: 60  IDQMLQRGQVDMAVHCMKDVPGDVPMPRGLIFAAYLPRDDVRDVLLVPEGSDVQSLAGLP 119

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD-----NGEYDAIILAVAGLK 175
            G+ V TS++RR+ Q+   RPDL +  +RG VG+R+ KLD     +   DA++LA AGL+
Sbjct: 120 PGASVATSAVRRKAQINRVRPDLNVVRVRGLVGSRIDKLDGRKPMDHMLDAMVLARAGLE 179

Query: 176 RLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235
           RL L  R R        LPAVG GA+G+ECR DD     LL  LN   T   +TAER M 
Sbjct: 180 RLDLMHRARQVFEVAEMLPAVGAGALGLECREDDDAVAYLLQQLNDEPTMTEITAERVML 239

Query: 236 TRLEGGCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRG-APQDAEQMGISLAEE 293
             L G C  PI  +     DG++ LR +V + DGS+ +     G +  D   +G  +  E
Sbjct: 240 HGLRGHCNSPIAGHCVTDPDGQLSLRGMVFSRDGSKFVHAHFWGESMNDPAVLGSRVCAE 299

Query: 294 LLNNGAREILAEVY 307
           LL  GAR+I+  + 
Sbjct: 300 LLRQGARDIIEGIP 313


>UniRef50_C1AA38 Porphobilinogen deaminase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1AA38_GEMAT
          Length = 309

 Score =  337 bits (866), Expect = 2e-91,   Method: Composition-based stats.
 Identities = 153/312 (49%), Positives = 188/312 (60%), Gaps = 8/312 (2%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M+   +RI TR S LAL QA  V  +L A   G+  ELV   T GD ILD PL+ +G KG
Sbjct: 1   MMTVPVRIGTRSSELALRQARQVAAQLDAR--GVPSELVEYTTLGDRILDRPLSAIGEKG 58

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLD 117
           LF  ELE  LL  R D AVHS+KD+P   PQG+ +V + EREDPRDA V        SLD
Sbjct: 59  LFTAELEADLLAGRIDCAVHSLKDLPTADPQGIIVVALLEREDPRDALVVRAGVDAHSLD 118

Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177
            LP G+ VGTSSLRR+ QL   R DL +  LRGNVGTRL KLD G+ DA +LA AGL RL
Sbjct: 119 TLPEGARVGTSSLRRRAQLQALRSDLEVCELRGNVGTRLRKLDEGQVDAALLAAAGLHRL 178

Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237
           GL  RI A L     L A GQGA+ ++ R DD      L++L+H  T + VTAERA+   
Sbjct: 179 GLADRIVAYLDAPEWLSAPGQGAIAVQGRADDEALLSTLSSLDHAPTRVAVTAERALLAA 238

Query: 238 LEGGCQVPIGSYAELIDGE--IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295
           LEGGCQVPIG+ A L + E    L A++ + DGS  +RG       +    GI LA +L 
Sbjct: 239 LEGGCQVPIGA-AVLEEPEYGTILHAVIVSLDGSSAVRGGYPVDHANPAASGIELARQLR 297

Query: 296 NNGAREILAEVY 307
             G  +IL+E+ 
Sbjct: 298 AAGGAQILSEIR 309


>UniRef50_Q82P95 Porphobilinogen deaminase 2 n=14 Tax=Actinomycetales
           RepID=HEM32_STRAW
          Length = 314

 Score =  336 bits (863), Expect = 5e-91,   Method: Composition-based stats.
 Identities = 124/307 (40%), Positives = 168/307 (54%), Gaps = 4/307 (1%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
            ++RI +R SP+AL Q   V+ +L A HP    E+V + T GD  +   L+KV GKG F 
Sbjct: 8   ELIRIVSRDSPMALAQVARVRAELAALHPRTRTEVVAVKTTGDKWMGD-LSKVDGKGAFT 66

Query: 64  KELEVALLENRADIAVHSMKDVPV--EFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           KE++ ALL   AD+AVH +KDVP     P G       +R+D RDA V     +LD LP 
Sbjct: 67  KEVDAALLAGEADLAVHCVKDVPADRPLPAGTMFAAFLKRDDIRDALVHPGGLTLDELPP 126

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ +GTSS+RR  QLA   P L     RGN   RL KL  GE DA++LAV+GL+R+G E 
Sbjct: 127 GTRIGTSSVRRVAQLAAAYPHLECVPFRGNANRRLEKLAAGEADALLLAVSGLERIGRED 186

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
            I   L PE  +P +G G + ++CR  D+   E ++ L    T    TAER     L+G 
Sbjct: 187 VITEVLEPETMMPPIGAGILALQCREGDTGLIETISELGDPGTHREATAERMFLHVLQGH 246

Query: 242 CQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           C  PI  YA    +GE+ LRA V   DG  ++         D   +G S+A  LL  GAR
Sbjct: 247 CNSPIAGYARTERNGELSLRASVFTLDGKTVLNAHEWAGRLDPATLGTSVAVALLRQGAR 306

Query: 301 EILAEVY 307
           E++ ++ 
Sbjct: 307 ELIDDIP 313


>UniRef50_Q8TXC8 Probable porphobilinogen deaminase n=1 Tax=Methanopyrus kandleri
           RepID=HEM3_METKA
          Length = 298

 Score =  333 bits (855), Expect = 5e-90,   Method: Composition-based stats.
 Identities = 122/299 (40%), Positives = 175/299 (58%), Gaps = 3/299 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHP-GLVVELVPMVTRGDVILDTPLAKVGGKG 60
           +   +R+ATR S LA+ Q   V + L    P  + VE+V   +RGDV+ D PL K+G KG
Sbjct: 1   MSETIRVATRSSRLAIIQTREVIELLERESPRDVEVEIVKTKSRGDVVRDRPLHKLGEKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           +FVKE++  +LE +ADIAVHS KDVP      + +  +  R DPR+  VS +   L  LP
Sbjct: 61  VFVKEVDRLVLEGKADIAVHSAKDVPSVVDYPVDVAAVPPRRDPRECLVSRHG-GLKELP 119

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ VGTSS RR+ Q+   RPDL +  +RGNV TR+SK+   EYDA +LA  GL RLG+ 
Sbjct: 120 RGATVGTSSPRRRAQILLERPDLKVEPMRGNVDTRVSKVRRREYDAAVLAKVGLDRLGMT 179

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
           S +     PE  +P  GQGA+ I CR DD R + LL  ++  ++ + V  E+A+   L  
Sbjct: 180 SEVSEVYDPEEFVPPAGQGALMITCRKDDDRVKRLLEVVDDEKSRVEVETEKAVVRELGV 239

Query: 241 GCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
           GC  P+G +    DG+ + L   +   DGS     + RG+P+D  +  +S A E+L++G
Sbjct: 240 GCSEPVGVHVRARDGDHVRLVLGLFEEDGSCGHVLKMRGSPEDVVREAVSQAREVLSDG 298


>UniRef50_A4QB59 Porphobilinogen deaminase n=15 Tax=Corynebacterium RepID=HEM3_CORGB
          Length = 302

 Score =  333 bits (855), Expect = 5e-90,   Method: Composition-based stats.
 Identities = 118/304 (38%), Positives = 171/304 (56%), Gaps = 8/304 (2%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            L+I TR S LA  QA  ++D+L   + G   EL  + T GDV + +P+ ++G  G+F +
Sbjct: 2   TLKIGTRGSKLATTQAGTIRDQLK--YFGRDAELHIVTTPGDVNM-SPVERIG-VGVFTQ 57

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
            L   L     D+AVHSMKD+P        LV +  R D R+A ++ +  +L  LP G+ 
Sbjct: 58  ALRDVLHAGECDVAVHSMKDLPTAADPRFHLV-VPTRADSREALIARDGLTLAELPEGAK 116

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGTS+ RR  QL   RPDL I  LRGN+ TR+ K+ +GE DA++LA AGL R+G++ R  
Sbjct: 117 VGTSAPRRISQLKAIRPDLEILPLRGNIDTRMGKVTSGELDAVMLAYAGLTRVGMQDRAT 176

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
                +I +PA  QGA+ IECR DD+ T   L  L H +T +   AER +  RLE GC  
Sbjct: 177 EVFDADIIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVLNRLEAGCTA 236

Query: 245 PIGSYAELI---DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           P+ ++A L       + L A V A DGS  +     G     E++G  +A++L++ GA  
Sbjct: 237 PVAAHATLDGYSGDTMTLTAGVYALDGSDQLVFSAEGDGARPEELGELVAQQLIDAGAAN 296

Query: 302 ILAE 305
           +L +
Sbjct: 297 LLGD 300


>UniRef50_A2BL26 Probable porphobilinogen deaminase n=2 Tax=Thermoprotei
           RepID=HEM3_HYPBU
          Length = 303

 Score =  332 bits (853), Expect = 8e-90,   Method: Composition-based stats.
 Identities = 127/298 (42%), Positives = 167/298 (56%), Gaps = 3/298 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LR+ATR S L++ Q     + +    P L  ELV + TRGD+  D P   +GGKGLF KE
Sbjct: 3   LRVATRGSKLSIAQTMIALEAIKRVEPSLEYELVIVKTRGDIHQDKPFTAIGGKGLFEKE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY--DSLDALPAGS 123
           + +A+LE RADIAVHS+KDVP     GL L     R+ P D  V       ++  LP+G+
Sbjct: 63  VNLAVLEGRADIAVHSLKDVPSAISPGLVLAMTPPRDPPYDVLVVRGGKEKTIWDLPSGA 122

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           IVGTSS RR   L   R DL+ + LRGNV TRL KL+ G+YDAI+LA AGLKRLG++   
Sbjct: 123 IVGTSSARRVAMLKHVRRDLVFKVLRGNVDTRLRKLEQGQYDAIVLAEAGLKRLGVDIEY 182

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
               PP+I  PA GQG +G+      S    +L   +  +      AERA      GGC 
Sbjct: 183 WRI-PPDILPPAPGQGIIGVYTLSSRSDILPILEKASDQKAMAEARAERAFLAYAGGGCH 241

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
            P+G+YAEL    ++  A + +PDGS+ +     G P    Q+G+  A EL    ARE
Sbjct: 242 TPLGAYAELRGNTLYFHAALASPDGSRRVEVRVEGDPDKPTQVGLEAAFELRRLAARE 299


>UniRef50_D0J8N1 Porphobilinogen deaminase n=2 Tax=Blattabacterium
           RepID=D0J8N1_BLASP
          Length = 310

 Score =  332 bits (852), Expect = 1e-89,   Method: Composition-based stats.
 Identities = 99/306 (32%), Positives = 151/306 (49%), Gaps = 7/306 (2%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           ++ ++RI TR SPLA+ QA  V+  L     G    L  + + GD+I + PL K    G+
Sbjct: 1   MNKIIRIGTRNSPLAISQAIEVQKVLHRL--GYCSHLFFIKSEGDLIQNIPLYKFKKVGI 58

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS-LDALP 120
           F + L   LL  + D+AVHS+KDVP   P+ + L    +R    D  +     + L    
Sbjct: 59  FTRNLTDVLLSGKIDMAVHSLKDVPTSLPEKIVLSAYLKRGSFSDLLIYQGSSNFLLNSK 118

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
             +++ T SLRR+     R P   I  LRGN+ TRL KL N  +   I A  GL+RLGL 
Sbjct: 119 IEAVIATGSLRRRAFWKNRYPHHTIVDLRGNINTRLKKLYNNSWKGAIFAKVGLERLGLL 178

Query: 181 SRIRAALP--PEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
           + +        +  +P+ GQG + +  R D+     L   L+   T L    ER     L
Sbjct: 179 NDLEGFNFKVLDWMIPSPGQGIIVVSTRKDNEWIHYLTKELDDRNTRLSANIERQFLKTL 238

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
            GGC  PIG++A + +  I+   ++ + DG Q IR ++ G   +   +G   A+E+L  G
Sbjct: 239 GGGCVTPIGAHAIIKNKIIYFTGILFSLDGMQKIRKKKIGT--NYNVIGYQCAKEILEEG 296

Query: 299 AREILA 304
            ++IL 
Sbjct: 297 GKKILE 302


>UniRef50_C1F251 Hydroxymethylbilane synthase n=1 Tax=Acidobacterium capsulatum ATCC
           51196 RepID=C1F251_ACIC5
          Length = 312

 Score =  332 bits (852), Expect = 1e-89,   Method: Composition-based stats.
 Identities = 138/321 (42%), Positives = 178/321 (55%), Gaps = 37/321 (11%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAK----VGGKG 60
           ++RI +R S LALWQA+++  +L      + +E+  + T GD +     AK    +GGKG
Sbjct: 1   MMRIGSRGSQLALWQANHIAARLRTLGHEVTIEI--IRTTGDALQHVTFAKVSTELGGKG 58

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           +F KE+E AL E R D+AVHS+KD+P +      L  I ER DPRDA +S  Y SL +LP
Sbjct: 59  IFTKEIEEALREGRIDLAVHSLKDLPTDLDPAFTLAAIPERVDPRDALLSARYTSLASLP 118

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ VGTSS RR+ QL   R DL  +  RGNV TR+ K+  G+ DAIILA AGL+RLGL 
Sbjct: 119 HGACVGTSSERRRAQLLVHRSDLRFQEFRGNVDTRIRKMVEGQADAIILASAGLERLGLT 178

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
              R  L PEI  PA GQGA+ IE R DD+ T  +LA+L+H  T   VTAER     L G
Sbjct: 179 EYRRECLAPEILCPAAGQGALAIETRADDAETLAILASLDHSATRYAVTAERTALASLGG 238

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ------------------- 281
           GCQVPIG +   + G           DG+  I+G   GA                     
Sbjct: 239 GCQVPIGIHCAPVPG----------ADGAYAIQGVVAGAAAKAASSAAHPVIRVAFEHQQ 288

Query: 282 --DAEQMGISLAEELLNNGAR 300
               + +G  LAEELL  GA+
Sbjct: 289 GLSPQALGRQLAEELLRQGAQ 309


>UniRef50_C8WIZ2 Porphobilinogen deaminase n=2 Tax=Coriobacteriaceae
           RepID=C8WIZ2_EGGLE
          Length = 327

 Score =  332 bits (852), Expect = 1e-89,   Method: Composition-based stats.
 Identities = 137/318 (43%), Positives = 183/318 (57%), Gaps = 13/318 (4%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR S LALWQAH+V D L A+ PG+ V +  + T+GD IL   L+K+G KGLF KE
Sbjct: 4   MRIGTRGSKLALWQAHHVADLLRAASPGMDVSVEVVKTKGDRILGVALSKIGDKGLFTKE 63

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           LE AL + R D+ VHSMKDVP   P+GL L     R D RD  V+ +  +   LPAGS V
Sbjct: 64  LEQALFDGRVDVCVHSMKDVPTALPEGLALAGCLIRADARDVLVAASGTTFAGLPAGSRV 123

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GT +LRR  QL   R DL    +RGN+ TR++K+ +G  DA++LA AG++R+G  + +  
Sbjct: 124 GTGALRRLSQLRAVRDDLDYVEVRGNLDTRIAKVRDGALDAVVLAAAGIERMGWSAEVAE 183

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
           A   +  +PAVGQGA+G+E R DD RT    A +    T   V AER +   L+GGCQVP
Sbjct: 184 AFSVDTVVPAVGQGAIGLEVRADDERTARACAQVRCAATDACVAAERHVMRALDGGCQVP 243

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGE-------------RRGAPQDAEQMGISLAE 292
           IG+YA   +G + L A VG+ DGS ++R                  A ++A  +     E
Sbjct: 244 IGAYARYEEGLLVLDAFVGSLDGSHVLRSRLSAASQPPNDTDAVEAAVREARALAQRAVE 303

Query: 293 ELLNNGAREILAEVYNGD 310
           E    GAR +L  V    
Sbjct: 304 EFEAQGARAVLDAVRAAG 321


>UniRef50_A8MGE4 Porphobilinogen deaminase n=30 Tax=cellular organisms
           RepID=HEM3_ALKOO
          Length = 296

 Score =  332 bits (852), Expect = 1e-89,   Method: Composition-based stats.
 Identities = 113/292 (38%), Positives = 160/292 (54%), Gaps = 5/292 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +R+ +R+S LA+ Q+  V + +    P + +ELV M T GD+ LD  L K+GGKGLF+KE
Sbjct: 3   IRVGSRESKLAVKQSEIVIEAIRKYDPNIEIELVTMKTTGDIKLDQTLDKIGGKGLFIKE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L+ AL ++R DI VHS KD+P+   + L +V + +REDPRD  V     ++        +
Sbjct: 63  LDQALYDDRVDITVHSFKDMPMAIDEYLPIVAVSKREDPRDVLVLPK--TVKEPDFSKPI 120

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           G SS RR+ QL E  P   +  +RGNV TRL KLD GE+ AI LA+AGLKRLGLE RI  
Sbjct: 121 GCSSFRRKIQLQEIYPHCSVEPIRGNVLTRLEKLDRGEFSAITLALAGLKRLGLEERISR 180

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
                  LPA  QG + ++ R         L+  +  E      AER+    L GGC  P
Sbjct: 181 IFEVTEILPAACQGVIVVQARKG--FDVSFLSDFHDKEAWDISMAERSFVRTLNGGCSSP 238

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           + +Y E+ D  + L  L      S + +    GA +  E+MG +LA ++   
Sbjct: 239 VAAYGEIKDNYLTLTGLYVDSSNS-VHKKTITGARKQGEEMGFNLALQMKGE 289


>UniRef50_C7NFP7 Hydroxymethylbilane synthase n=7 Tax=Actinomycetales
           RepID=C7NFP7_KYTSD
          Length = 358

 Score =  331 bits (850), Expect = 2e-89,   Method: Composition-based stats.
 Identities = 134/327 (40%), Positives = 179/327 (54%), Gaps = 33/327 (10%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
            V+R+ TR+S LA  Q+ +V D L A   G  VELV + T GDV    PL+++GG G+FV
Sbjct: 14  RVVRLGTRRSDLATTQSTHVADALRAR--GHEVELVLVTTEGDVNR-APLSRIGGTGVFV 70

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
             L  ALL    DIAVHS+KD+PV  PQ L +  + EREDPRDA V+ +  +L+ LPAG+
Sbjct: 71  SALRDALLAGEIDIAVHSLKDLPVAQPQELVIAAVPEREDPRDALVARDGLTLETLPAGA 130

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            VGT S RR+ QL   RPDL +  LRGNV  RL+ +  GE DA++LA AGL+RLGL   +
Sbjct: 131 RVGTGSPRREAQLRVARPDLEVVDLRGNVPRRLATVAEGELDAVVLAGAGLRRLGLTEHV 190

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              L P++ +PA GQGA+ +ECR DD+ +  +L  L+H  T    TAERA+   LE GC 
Sbjct: 191 TQWLEPQVMVPAPGQGALAVECRSDDAESIAMLEPLDHLPTRTATTAERAVLGTLEAGCS 250

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQII------------------------------R 273
            PIG+ A      + L    G  DGS+ +                               
Sbjct: 251 APIGALARHDGARVDLMTFAGPRDGSRALLEADCARGVPAGHPADTPDDTPADTPDDSRN 310

Query: 274 GERRGAPQDAEQMGISLAEELLNNGAR 300
            +R      A ++G  +AE L   GA 
Sbjct: 311 DDRVALDTAARELGRRVAEALRGGGAD 337


>UniRef50_B3DZQ6 Porphobilinogen deaminase n=1 Tax=Methylacidiphilum infernorum V4
           RepID=B3DZQ6_METI4
          Length = 298

 Score =  330 bits (848), Expect = 3e-89,   Method: Composition-based stats.
 Identities = 114/296 (38%), Positives = 164/296 (55%), Gaps = 3/296 (1%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             L I +R S LAL QA  + D L   +P L +++  + T GD +   P+  +  +G+F 
Sbjct: 2   KPLIIGSRGSRLALIQAQLIVDSLKKEYPLLDIQIRVIKTTGDHLEAQPIRDIDQRGIFT 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KE+E  LLE   D+AVHS+KD+ VE    L +  I  REDPRD ++S  +    +L AG+
Sbjct: 62  KEIENKLLEGEIDLAVHSLKDLQVELHPRLVIAAIPPREDPRDCWISLQHPHPSSLQAGA 121

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG-EYDAIILAVAGLKRLGLE-- 180
           IV T S RR  QL  +RPDL I  +RGNV +RL KL    ++   +LA+AG+KRLG++  
Sbjct: 122 IVVTGSPRRANQLLRKRPDLRIVPVRGNVESRLRKLRENRQWQGTVLALAGIKRLGIDIS 181

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
           S     L  +  LPA GQGA+ ++ R++D  T+ L+  LN   TA  VTAER     L G
Sbjct: 182 SFFCTPLSMDWMLPAPGQGALALQARIEDKHTQSLVKHLNDFSTACAVTAERVFLHELGG 241

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
           GC+  +G+ AE+    + L  +       +   G+  G    AE +G  LA+ L N
Sbjct: 242 GCRTAVGARAEVEGSRLVLEGIWWPQQAIEPKEGKVVGEIHRAEDLGKKLADLLKN 297


>UniRef50_Q09899 Porphobilinogen deaminase n=2 Tax=Schizosaccharomyces
           RepID=HEM3_SCHPO
          Length = 336

 Score =  330 bits (847), Expect = 4e-89,   Method: Composition-based stats.
 Identities = 126/314 (40%), Positives = 178/314 (56%), Gaps = 16/314 (5%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG---GKGLFVK 64
           I TR+S LA+ Q+  ++++L   +P L   ++   T GD IL   L +      K L+ +
Sbjct: 9   IGTRKSKLAVIQSEIIREELEKHYPHLEFPIISRDTIGDEILSKALFEFKRQLAKSLWTR 68

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALPA 121
           ELE  L+ N+  I VHS+KD+P E P G+ +  I +R  P DA V     +Y ++  LP 
Sbjct: 69  ELEALLVTNQCRILVHSLKDLPSEMPDGMVIACIPKRSCPLDAIVFKAGSHYKTVADLPP 128

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLKRLGL 179
           GS+VGTSS+RR+  LA   P L    +RGNVGTRL+KLD  + ++D ++LA AGL RLGL
Sbjct: 129 GSVVGTSSIRRRALLARNFPHLRFVDIRGNVGTRLAKLDAPDSQFDCLVLAAAGLFRLGL 188

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
           + RI   L       AVGQGA+ +E R DD    E+L  L H ET     AERA+  RL+
Sbjct: 189 KDRIAQMLTAPFVYYAVGQGALAVEVRADDKEMIEMLKPLQHQETLYACLAERALMKRLQ 248

Query: 240 GGCQVPIGSYAELI-----DGEIWLRALVGAPDGSQIIRGE---RRGAPQDAEQMGISLA 291
           GGC +PIG   +++        I L   V + DG +   G       + ++AE++GI++A
Sbjct: 249 GGCAIPIGVQTDVLAISNSSYRISLLGTVLSADGLRAAFGNAEAVVSSEEEAEELGITVA 308

Query: 292 EELLNNGAREILAE 305
             LL NGA  IL E
Sbjct: 309 LALLKNGAGPILEE 322


>UniRef50_Q0BX92 Porphobilinogen deaminase n=1 Tax=Hyphomonas neptunium ATCC 15444
           RepID=HEM3_HYPNA
          Length = 321

 Score =  329 bits (844), Expect = 9e-89,   Method: Composition-based stats.
 Identities = 120/298 (40%), Positives = 166/298 (55%), Gaps = 7/298 (2%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPG-LVVELVPMVTRGDVILDTPLAKVGGKGLF 62
             LR+ TR SPLAL QAH + D + A+  G    E+V   T GD +    L   GGKGLF
Sbjct: 11  KRLRLGTRGSPLALAQAHQIADGIRAASAGAYDCEIVAFTTTGDKLTTERLINSGGKGLF 70

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122
            +EL+ AL     D+AVHS+KDVP   P G       +REDPRD F+S+   S+  LP G
Sbjct: 71  TRELDDALSRGELDLAVHSLKDVPSVLPPGQIFAAFPKREDPRDGFLSHGAKSIQDLPEG 130

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           + +GT+SLRR+ Q    RPDL + + RGNV TR+ KL+ G  DA  LA+AGL RLGL   
Sbjct: 131 ATLGTASLRREAQALALRPDLKVVTFRGNVATRMRKLEEGLADATFLAMAGLTRLGLSEV 190

Query: 183 IRAALPPEISLPAVGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
               +P E  LPA GQG +G+  R D D+   E+L  L+H  + +   AERA   +L+G 
Sbjct: 191 AT-PIPLEDMLPAAGQGIIGVVTRDDVDTELLEILGQLSHEPSRVAAIAERAFLEKLDGS 249

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQ----MGISLAEELL 295
           C+ PI ++      E  L   V +P G+   RG+        +     +G ++A+E++
Sbjct: 250 CRTPIAAHLFDRGDEWQLIGEVLSPGGTTRWRGDGVCRKDATDAQLVLLGRAVAQEII 307


>UniRef50_A0DD68 Chromosome undetermined scaffold_46, whole genome shotgun sequence
           n=2 Tax=Paramecium tetraurelia RepID=A0DD68_PARTE
          Length = 306

 Score =  328 bits (843), Expect = 1e-88,   Method: Composition-based stats.
 Identities = 125/312 (40%), Positives = 172/312 (55%), Gaps = 13/312 (4%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTR-GDVILDTPLAKVGGKG 60
           +   LRIATR S LA+ Q +YV  +L         E++ +    GDV L  PL ++   G
Sbjct: 1   MQRQLRIATRSSALAMAQTNYVISELKQ-----ECEIIKVSNEVGDVNLQDPLYQMPTVG 55

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLD 117
           +F K++E  LLE +AD+AVHS+KD+P      L L    + E   D  + N    Y SL 
Sbjct: 56  VFTKQVEQYLLEQKADVAVHSLKDLPTIIDAQLHLAAYTKFEQRGDVVLLNKKYNYKSLS 115

Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177
            LP G  VGTSSLRR   +  R P L + ++RGN+ TR+ KLD G+YDAIILA AG+ RL
Sbjct: 116 ELPDGLKVGTSSLRRIATIRSRYPKLNLINIRGNLNTRIQKLDEGQYDAIILAKAGILRL 175

Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237
           GL  +I   L  +  L A  Q A+GI+CR DD  T   L  LN  +   R  AER     
Sbjct: 176 GLAEKISFDLDEKEFLYAPAQAALGIQCRKDDLETIGRLQILNDTDAQKRCVAERMFLNL 235

Query: 238 LEGGCQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
           LEGGC++PI  Y+E   DG+++++  V A DGS++I  E   A    E +G  L E++  
Sbjct: 236 LEGGCRLPIAVYSECREDGQVYIKGRVLAVDGSKVIEDE---ALDHFEIVGQILCEKIKV 292

Query: 297 NGAREILAEVYN 308
            G  E++  +  
Sbjct: 293 LGGVELIESLKQ 304


>UniRef50_A4XK06 Porphobilinogen deaminase n=2 Tax=Clostridia RepID=HEM3_CALS8
          Length = 290

 Score =  328 bits (841), Expect = 2e-88,   Method: Composition-based stats.
 Identities = 103/293 (35%), Positives = 155/293 (52%), Gaps = 4/293 (1%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             LRI  R S L+  Q   V  K+  +  G+  E VP+ T+GD+     L      G+FV
Sbjct: 2   KKLRIGARDSKLSRIQVDIVARKIKQT-LGIECEFVPIKTKGDIDKTKSLKDFKSPGVFV 60

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KE+E+ALL    D+AVHS+KD+P E      +V + EREDPRD  VS +      L   +
Sbjct: 61  KEIELALLSREIDLAVHSLKDLPCEMDSNFEIVAVVEREDPRDVLVSKDGVGFYQLKPNA 120

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            +GTSSLRR+  L   R D+ + ++RGN+ TRLSK+++   D ++LA A LKRL L+S +
Sbjct: 121 KIGTSSLRREVHLKNLRQDIQVVNIRGNIETRLSKIESEGLDGVVLAYAALKRLNLDSHV 180

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
                     P  GQGA+ IEC L DS  + +L+ +N  +  ++   ER +   L GGC 
Sbjct: 181 SYIFDVNEITPCPGQGAICIEC-LKDSPYKNILSKINDADAYIQTQFERLVLKFLGGGCH 239

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
             IG + +    +I+  A + +  G ++I+    G   D   +   L+  L +
Sbjct: 240 SSIGVFCKTDQDKIYAFASILS--GDKLIKASIEGDKDDFLSLANKLSNMLKS 290


>UniRef50_C4QMG7 Hydroxymethylbilane synthase (Porphobilinogen deaminase, putative)
           n=1 Tax=Schistosoma mansoni RepID=C4QMG7_SCHMA
          Length = 411

 Score =  327 bits (839), Expect = 4e-88,   Method: Composition-based stats.
 Identities = 117/302 (38%), Positives = 161/302 (53%), Gaps = 25/302 (8%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           NV+R+ +R+S LAL Q     + L   +P ++ E+V M T GD ILD  L+K+G K LF 
Sbjct: 8   NVVRVGSRRSNLALLQTGMAVNLLQKQNPHILFEVVEMATVGDKILDVSLSKIGDKSLFT 67

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDSLDALP 120
           KELE ALL    D+ VHS+KDVP   P GL L  +  R  P D  +         L  LP
Sbjct: 68  KELENALLSGEVDLVVHSLKDVPSTLPSGLVLGCVFARVSPEDVVLMAPHYRGRKLSDLP 127

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--------------NGEYDA 166
            GS VGTS++RR   L  + P L   S+RGN+ TRL+KLD              +  YDA
Sbjct: 128 IGSTVGTSAVRRVATLTRKYPHLKFVSIRGNLNTRLAKLDTPPASKDNCCSGNPSPSYDA 187

Query: 167 IILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETAL 226
           IILA AG++R+G   RI   L       AV QGA+  ECRL D+   +LL+ ++    AL
Sbjct: 188 IILAKAGVERMGWSHRIDQVLTDSF--YAVSQGALACECRLVDNFIMDLLSHIHDESAAL 245

Query: 227 RVTAERAMNTRLEGGCQVPIGSYAELI--DG----EIWLRALVGAPDGSQIIRGERRGAP 280
              AER++  +L+GGC +PIG  ++L+        ++ L A + + DG + I        
Sbjct: 246 TTIAERSLMRQLDGGCSIPIGVRSDLVLKGDLNYYQLTLHANILSVDGGKSIERSASVVF 305

Query: 281 QD 282
            D
Sbjct: 306 PD 307


>UniRef50_Q8D2W2 HemC protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of
           Glossina brevipalpis RepID=Q8D2W2_WIGBR
          Length = 291

 Score =  327 bits (838), Expect = 5e-88,   Method: Composition-based stats.
 Identities = 132/289 (45%), Positives = 193/289 (66%), Gaps = 1/289 (0%)

Query: 20  AHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAV 79
           +   K KL+  HP L ++LVP++T GD+I          KGLF+KELE +LL+ ++DIAV
Sbjct: 3   SKLCKKKLLHYHPKLNIKLVPILTTGDLINKIRNNITNEKGLFIKELEKSLLKYQSDIAV 62

Query: 80  HSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAER 139
           HSMKD    F   LGL  IC+R+DPRDA VSN Y+++ +LP  + VGTSSLRR+CQL   
Sbjct: 63  HSMKDFSSSFLDSLGLAAICKRDDPRDAIVSNYYNNIISLPNNAKVGTSSLRRKCQLLSI 122

Query: 140 RPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQG 199
           RPDL I   +GN+ +RL KL+ G +DA+ILA A LKRL +  ++   + P   LPA+GQG
Sbjct: 123 RPDLKIFPCKGNIHSRLKKLNQGVFDALILATAALKRLKINEQMYTPIDPSYLLPAMGQG 182

Query: 200 AVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID-GEIW 258
           ++ I+CRL D++  +++  +N+ +TAL + +E+ + + L  GC+VPIGSYA++ +   IW
Sbjct: 183 SIAIQCRLYDNKIIDIVRNINNKKTALCINSEKIVVSMLGTGCRVPIGSYAKIENKNTIW 242

Query: 259 LRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVY 307
           +RALVG+ DGS IIR E +    +AE++     + L+N GA+ IL +  
Sbjct: 243 IRALVGSIDGSNIIRSEGKSCVSNAEKLSKKQVKNLINLGAKNILKKFK 291


>UniRef50_Q7UPN0 Porphobilinogen deaminase n=1 Tax=Rhodopirellula baltica
           RepID=HEM3_RHOBA
          Length = 337

 Score =  326 bits (837), Expect = 5e-88,   Method: Composition-based stats.
 Identities = 128/329 (38%), Positives = 183/329 (55%), Gaps = 27/329 (8%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LRIATR+SPLA+WQA +V   L     G   E+VP+V++GD  +  P+      GLF K 
Sbjct: 12  LRIATRESPLAMWQAEHVAKLLKKH--GFQTEIVPLVSKGDTDM-RPIDGTRQVGLFTKR 68

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS---------- 115
           ++ AL+++ AD+AVHS+KD+P E      L  +  RE   DA V  +             
Sbjct: 69  IQQALVDDEADVAVHSLKDLPTEPDSRFVLAAVPPRESVLDALVFADNSPHLESQTGAES 128

Query: 116 -LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174
            LD LP G+ VGT S RR  QL + RPDL +  +RGNV TRL+KL+ GE+DAI+LA AG+
Sbjct: 129 PLDYLPQGARVGTGSTRRLAQLKQLRPDLEVLPIRGNVQTRLAKLNAGEFDAIVLAHAGI 188

Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234
            RL +        P +  +PA GQGA+GIE R DD+   + +A LN     L  TAER +
Sbjct: 189 LRLEMTDLPHRLFPLDEMIPAPGQGALGIEVRSDDAGAMDAIANLNDAAARLAATAERKV 248

Query: 235 NTRLEGGCQVPIGSYAELI----DGEIWLRALVGAPDGSQIIRGERRGAPQ--------- 281
            + L GGC  PI  +A+L       E+ LRA+V + DG Q ++ + R   Q         
Sbjct: 249 LSELHGGCLAPIACHAKLETSNHGTELCLRAIVMSADGEQRLQEDARITVQPNDADLHVA 308

Query: 282 DAEQMGISLAEELLNNGAREILAEVYNGD 310
           +A ++G  +A+ L + GA ++++ V    
Sbjct: 309 EAHELGTLVAKRLRDKGADKLISTVRENH 337


>UniRef50_A4CHM3 Porphobilinogen deaminase n=4 Tax=Bacteroidetes RepID=A4CHM3_9FLAO
          Length = 315

 Score =  325 bits (833), Expect = 2e-87,   Method: Composition-based stats.
 Identities = 123/318 (38%), Positives = 168/318 (52%), Gaps = 18/318 (5%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   LRI TR S LALWQA  V+D+L A+  G   ELVP+ + GD++LD PL ++G  G+
Sbjct: 1   MSRALRIGTRDSELALWQAQTVRDRLEAA--GHRAELVPVKSTGDLVLDKPLYELGITGI 58

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F K L+VALL    D+AVHSMKDVP   P+G+    + ER   RD  V      LD    
Sbjct: 59  FTKTLDVALLREDIDLAVHSMKDVPTALPEGICQAAVLERASARDVLVHKGLGFLDG--P 116

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G  + T SLRR+ Q   R P   +  LRGNV TRL  L    +D  I A AGL+R+GL  
Sbjct: 117 G-TIATGSLRRKAQWLNRYPAHQVTGLRGNVNTRLKLLRENSWDGAIFAQAGLERIGLLP 175

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
                 P +  LPA  QGA+ +  R  D+  RE    L+H ++AL V  ER     LEGG
Sbjct: 176 DNAE--PLDWMLPAPAQGAMLVVARTSDTAAREAARPLHHEQSALEVAVEREFLRTLEGG 233

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER-RGAPQ----------DAEQMGISL 290
           C  PIG+     DG++ L   + + DG +  R  R  G+ +          DA + G + 
Sbjct: 234 CSAPIGARVHAADGQLHLEGGLFSLDGKKAFRVTRHTGSLEAGGTGDARFQDAGEFGAAC 293

Query: 291 AEELLNNGAREILAEVYN 308
           A E+L++G   ++  +  
Sbjct: 294 AREILDSGGAVLMESIRK 311


>UniRef50_Q4T5L1 Chromosome undetermined SCAF9206, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4T5L1_TETNG
          Length = 385

 Score =  325 bits (833), Expect = 2e-87,   Method: Composition-based stats.
 Identities = 135/376 (35%), Positives = 190/376 (50%), Gaps = 85/376 (22%)

Query: 13  SPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLE 72
           S LA  Q   V +KL   +P + +E+V M T GD ILDT L+K+G K LF KELE AL  
Sbjct: 1   SQLARIQTDSVAEKLKELYPDVHLEIVAMSTTGDKILDTALSKIGEKSLFTKELENALER 60

Query: 73  NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALPAGSIVGTSS 129
           N  D+ VHS+KD+P   P G  +  + +RE+P DA V +      +LDALPA S++GTSS
Sbjct: 61  NEVDLVVHSLKDLPTSLPPGFTIGAVLKRENPHDAVVLHPKNAGKTLDALPAHSVIGTSS 120

Query: 130 LRRQCQLAERRPDLIIRSL------------------------RGNVGTRLSKLDNGE-Y 164
           LRR  QL +R P L  + +                        RGN+ TRL KLD  E +
Sbjct: 121 LRRAAQLKKRFPHLDFKDIVSSERCFLPVQPGHRCFFLSSRSQRGNLNTRLKKLDEKEDF 180

Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224
            AIILA AGL+R+G ++RI   L PE  + AVGQGA+ +E R  D+   E+++ L+  +T
Sbjct: 181 AAIILAAAGLRRMGWDNRISQILEPEDCMYAVGQGALAVEVRAKDADILEMVSVLHDPDT 240

Query: 225 ALRVTAERAMNTRL----------------------------EGGCQVPIGSYAELIDGE 256
            LR  AERA    L                            EGGC VP+  + ++ D +
Sbjct: 241 VLRCIAERAFLKHLVQHTHTHTHTHTHTRSLAVAHWNLFCLQEGGCSVPVAVHTKVKDSQ 300

Query: 257 IWLRALVGAPDGSQIIRGERR--------GAPQD---------------------AEQMG 287
           ++L   V + DGS  ++   +        G+P +                     AE++G
Sbjct: 301 LYLTGAVYSLDGSDSLKETMQTSVAAPADGSPDEVDECARVGVTANKIPGEAQDRAERLG 360

Query: 288 ISLAEELLNNGAREIL 303
           + LA+ LL+ GA+EIL
Sbjct: 361 VDLAKLLLSKGAKEIL 376


>UniRef50_Q47LA7 Porphobilinogen deaminase n=3 Tax=Actinomycetales RepID=HEM3_THEFY
          Length = 320

 Score =  324 bits (832), Expect = 2e-87,   Method: Composition-based stats.
 Identities = 127/318 (39%), Positives = 177/318 (55%), Gaps = 11/318 (3%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M     R+ TR+S +A  Q+  V + L A   G+ VELV + + GD I    L ++GG G
Sbjct: 1   MSTTPARLGTRRSTMATNQSRRVAEILTAR-TGVPVELVLITSFGD-ITRAHLTQLGGTG 58

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           +FV  L  ALL    + AVHS+KD+P    +G+ L  + ER+DPRDA  + +      LP
Sbjct: 59  VFVSALRDALLAGEVEFAVHSLKDLPTAPTEGIVLAAVTERDDPRDALCARDGLKFADLP 118

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ VGT S RR  QLA  RPDL    +RGN  TRL K+ +GE DA++LA AGL R+G  
Sbjct: 119 PGATVGTGSPRRVAQLAALRPDLRYVPIRGNAETRLGKVASGELDAVVLAYAGLHRVGRL 178

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDD-SRTRELLAALNHHETALRVTAERAMNTRLE 239
             +      +  LPA GQGA+ +ECR  D +     L A++H  T   VTAER +   LE
Sbjct: 179 DDVTDVFDVDQVLPAPGQGALAVECRTADFTGPLRYLTAVDHLPTRAAVTAERVILAELE 238

Query: 240 GGCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQD-------AEQMGISLA 291
            GC  P+G+YAE + +  + LRA V A DGSQ +R E+     +       A  +G  LA
Sbjct: 239 AGCAAPVGAYAEFVAEDRLRLRAAVVATDGSQAVRAEQTVTVTEFPDAVQAATALGRQLA 298

Query: 292 EELLNNGAREILAEVYNG 309
            +++  GA +I+A+   G
Sbjct: 299 HDMIEQGADQIVADAAAG 316


>UniRef50_C6XKH7 Porphobilinogen deaminase n=1 Tax=Hirschia baltica ATCC 49814
           RepID=C6XKH7_HIRBI
          Length = 323

 Score =  324 bits (831), Expect = 3e-87,   Method: Composition-based stats.
 Identities = 110/299 (36%), Positives = 153/299 (51%), Gaps = 7/299 (2%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPG-LVVELVPMVTRGDVILDTPLAKVGGKG 60
              +++I  R SPLA+ QA     +        + +E+    T GD +LD  L   GGKG
Sbjct: 17  STQIVKIGARGSPLAVQQAEDFAARFKEIVGNTVEIEIHTFTTSGDQLLDKRLQDAGGKG 76

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LF +EL++A L  R DI VHS+KDVP   P GL +     REDPRDA       ++  LP
Sbjct: 77  LFTRELDIAQLSGRIDIVVHSLKDVPTVLPDGLQMGCYLPREDPRDALFGKVG-NIKDLP 135

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ +GT+SLRR  Q    RPDL I   RGNV TRL KL+ G+ DA +LA AGL RLG+ 
Sbjct: 136 HGATLGTASLRRSAQALALRPDLKIVMFRGNVQTRLRKLEEGQADATLLAAAGLNRLGMT 195

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLE 239
            +    +P E  LPA GQG V      + +    +    ++  E+ +   AERA   RL+
Sbjct: 196 DKAAGFMPKEEMLPACGQGIVCTTLTNNAEDWIFKACLQIDVLESRIAAIAERAFLKRLD 255

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRG----APQDAEQMGISLAEEL 294
           G C+ PI  +    +  + +R  V A DGS+    +           A  +G  L E++
Sbjct: 256 GSCRTPIAGHLSFNETGVDMRGEVLADDGSKRWFSQMSLDTIPDENQAASLGFELGEKV 314


>UniRef50_Q9F7M2 Predicted porphobilinogen deaminase n=2 Tax=Bacteria
           RepID=Q9F7M2_PRB01
          Length = 303

 Score =  323 bits (830), Expect = 4e-87,   Method: Composition-based stats.
 Identities = 110/298 (36%), Positives = 170/298 (57%), Gaps = 2/298 (0%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RIATRQS LA++QA +V D+L+A    + VELVPM + GD   D PL ++GGKGLF+  
Sbjct: 3   IRIATRQSELAMYQAKFVADELLAKINNIKVELVPMTSEGDQ-TDKPLHEIGGKGLFIST 61

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           LE +L  + ADIAVHS+KDVP +      ++++  RE P D  +S +  S       S +
Sbjct: 62  LESSLEADEADIAVHSLKDVPAKLDPKFKIISVFSRESPEDLLLSKDGKSFSEFARNSTI 121

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTS  RR+ Q+   RPD+    +RGN+ TR+ KL++G +D +++A A +KRLGL+     
Sbjct: 122 GTSGPRRKAQINNLRPDIKTIPVRGNIATRIKKLNDGLFDGLVVAKAAIKRLGLKQNSYE 181

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
               E  LP+  QG + IEC  D     ELL  +   +  +  +AER+    +EG C  P
Sbjct: 182 F-SIEEMLPSASQGYIAIECLSDKKDIIELLENIGDPKELILASAERSFVAAMEGTCLSP 240

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           I    E  +G+I +   + + +G++ I  E+  + QD     +  A+E +  GA+ ++
Sbjct: 241 IAILCEDKNGQIKISGKILSYEGNEKIYKEKISSFQDIAIDIMLFADEFILEGAKSLI 298


>UniRef50_A3MLK5 Porphobilinogen deaminase n=155 Tax=Proteobacteria RepID=HEM3_BURM7
          Length = 329

 Score =  323 bits (829), Expect = 4e-87,   Method: Composition-based stats.
 Identities = 162/315 (51%), Positives = 208/315 (66%), Gaps = 3/315 (0%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           L   L IA+R+S LA+WQA +V+D L   +P   V+++ M TRGD ILD  L+KVGGKGL
Sbjct: 10  LPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGL 69

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FVKELE AL + RAD+AVHS+KDVP+  P+G  L  +  REDPRDAFVSN+Y SLDALPA
Sbjct: 70  FVKELESALADGRADLAVHSLKDVPMALPEGFALAAVMSREDPRDAFVSNDYASLDALPA 129

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G++VGTSSLRR+  L  R P L +R LRGN+ TRL+KLD G+Y AIILA AGLKRLGL +
Sbjct: 130 GAVVGTSSLRREAMLRARHPRLDVRPLRGNLDTRLAKLDRGDYAAIILAAAGLKRLGLAA 189

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
           RIRA L  + SLPA GQGA+GIE     +     LA L+ H +AL V AERA++  L G 
Sbjct: 190 RIRALLDVDDSLPAAGQGALGIEIAARRADVAAWLAPLHDHASALAVEAERAVSRALGGS 249

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQI---IRGERRGAPQDAEQMGISLAEELLNNG 298
           C+VP+ ++A    GE+ L   V   DG+++       R     DA  +G  +++ L   G
Sbjct: 250 CEVPLAAHAVWRGGELHLTGSVSTTDGARVLAAHAHARAATAADALALGRRVSDALERQG 309

Query: 299 AREILAEVYNGDAPA 313
           AR I+  +    A A
Sbjct: 310 ARAIVDALVAASAQA 324


>UniRef50_B2IAW6 Porphobilinogen deaminase n=4 Tax=Alphaproteobacteria
           RepID=B2IAW6_BEII9
          Length = 337

 Score =  323 bits (829), Expect = 5e-87,   Method: Composition-based stats.
 Identities = 138/306 (45%), Positives = 179/306 (58%), Gaps = 5/306 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           LR+ TR SPLAL QAH + D+L  +H      V +  + T GD+I D PL+  GGKGLF 
Sbjct: 19  LRLGTRGSPLALAQAHELADRLARAHGFAKEAVAITIIRTSGDMIQDRPLSLAGGKGLFT 78

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KEL+ AL+E   D+AVHS KD+P   P+ L +     RED RD ++S        LP GS
Sbjct: 79  KELDQALIEGMVDLAVHSAKDLPTILPEDLIIAGYLPREDVRDVWISPKAGHPRDLPPGS 138

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           +VGT+SLRR   L   RPDL +R LRGNV TRL+KL  GE DA +LA+AGL+RLGL  + 
Sbjct: 139 VVGTASLRRGALLKRLRPDLEVRLLRGNVETRLAKLAAGEVDATLLALAGLRRLGLADKA 198

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              L  E  LPA GQGA+GI  R DD+ T  LLA +    T + + AER   T L+G C+
Sbjct: 199 TQVLAIEDFLPAAGQGAIGITTRRDDAATLALLAPILDPATHVALAAERGFLTVLDGSCK 258

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
            PIG++A +   ++ LR +V  PDGS+       G  +      +  A EL    AR IL
Sbjct: 259 TPIGAHATVEHDQVTLRGIVLRPDGSEWFEACESGPLESGS---LEAARELGETAARAIL 315

Query: 304 AEVYNG 309
           A +  G
Sbjct: 316 ARLPEG 321


>UniRef50_C2GGB5 Porphobilinogen deaminase n=2 Tax=Corynebacterium glucuronolyticum
           RepID=C2GGB5_9CORY
          Length = 290

 Score =  323 bits (829), Expect = 5e-87,   Method: Composition-based stats.
 Identities = 121/299 (40%), Positives = 165/299 (55%), Gaps = 11/299 (3%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            LRI TR S LA  QA +V+D L+ +  G   EL  + T GD  L +P+ K+G  G+F +
Sbjct: 2   TLRIGTRGSKLATTQAGHVRDALIRA--GYDAELTIITTPGDKNL-SPVQKIG-VGVFTQ 57

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
            L  A+  +  DIAVHS KD+P   P+GL  +    RE P +A ++ +  +LD LP G+ 
Sbjct: 58  ALREAMDRDEIDIAVHSCKDLPTGQPEGLATI-YPVRETPCEALIARDGLTLDQLPEGAK 116

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGT + RR  QL   RPDL IR LRGNV TR+ K+ +GE DA+ILA AGL R+G      
Sbjct: 117 VGTGAPRRISQLKALRPDLDIRPLRGNVDTRMGKVTSGELDAVILAHAGLTRIGRGDEAT 176

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
               P   +PA  QG + +E R        L   ++ H T L   AERA+ + L+ GC  
Sbjct: 177 QVFDPTYLMPAPAQGILAVESRTHVDAISTL---IDDHAT-LSAQAERAVLSTLQAGCTA 232

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           P+ +Y+ +   EI L A   A DGS+ I     G   D   +G S+AE+L   GA EI+
Sbjct: 233 PLAAYSTVSGDEITLTAGAFALDGSKQIVETATGT--DPVALGTSVAEKLRACGAEEII 289


>UniRef50_B8GXG1 Porphobilinogen deaminase n=8 Tax=Caulobacteraceae RepID=HEM3_CAUCN
          Length = 322

 Score =  323 bits (828), Expect = 6e-87,   Method: Composition-based stats.
 Identities = 133/315 (42%), Positives = 177/315 (56%), Gaps = 17/315 (5%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMAS----------HPGLVVELVPMVTRGDVILDTPLA 54
            +RI  R S L+L Q+  ++ ++  +                 L+P+VT GD I D  L 
Sbjct: 6   PIRIGARGSKLSLAQSGLMQARIAHALGVPAGASKDEIEAAAPLIPIVTSGDRIQDRRLM 65

Query: 55  KVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD 114
           ++GGKGLF KE+E ALL+ R D AVHS+KD+P E P GL L    EREDPRDAF+S+  +
Sbjct: 66  EIGGKGLFTKEIEEALLDGRIDCAVHSLKDMPAELPPGLVLAATPEREDPRDAFISHVCE 125

Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174
            L+ LP G+ +GT+SLRRQ Q    RPDL I  LRGNV TRL+KL+ GE DAI+LA +GL
Sbjct: 126 RLEDLPKGARLGTASLRRQAQALHVRPDLEIVMLRGNVDTRLAKLERGEADAILLAQSGL 185

Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234
            RLGL    R+ L P+   PA GQGA+ IE R +D      L A+   +T + V AER  
Sbjct: 186 NRLGLGHLTRSWLDPDACPPAPGQGALVIETRAEDIG-APWLEAVRCRQTTIAVAAERGA 244

Query: 235 NTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE----RRG--APQDAEQMGI 288
              LEG C+  IG+ A L    + +      PDG+Q  R E      G     +A   G+
Sbjct: 245 LLALEGSCRTAIGARAILDGARLSMIVEALTPDGAQRFRREGDITLTGADDIAEARAFGL 304

Query: 289 SLAEELLNNGAREIL 303
           +L  E+   G   I+
Sbjct: 305 TLGAEVRAAGGDAII 319


>UniRef50_A8SQW4 Putative uncharacterized protein n=1 Tax=Coprococcus eutactus ATCC
           27759 RepID=A8SQW4_9FIRM
          Length = 350

 Score =  323 bits (828), Expect = 6e-87,   Method: Composition-based stats.
 Identities = 115/314 (36%), Positives = 165/314 (52%), Gaps = 26/314 (8%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62
              +++ TR S LAL Q   V   L    P +  ++V M TRGD      L + GGK +F
Sbjct: 39  KKTVKVGTRGSKLALAQTELVIKALNERFPQIDFQMVTMSTRGDRDTSRALLEFGGKAVF 98

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122
           V+E E A+L+   DIAVHS KD+P+E  +GL +     R  P+D F+  +  S D   + 
Sbjct: 99  VEEFEEAILKGDIDIAVHSAKDMPMEIMEGLTISGTLPRACPQDVFIYKSGRSFDRNDSF 158

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL--- 179
            +VGTSSLRRQ Q+ +  P+ + ++LRGNVGTR+ KL++GEYDAIILA AGL+RLG+   
Sbjct: 159 -VVGTSSLRRQYQIRDMYPNAVCKNLRGNVGTRIQKLEDGEYDAIILAAAGLERLGVIED 217

Query: 180 -------------ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETAL 226
                        +      L  E  LPA  QG + IE R       +++ A+N  E   
Sbjct: 218 KGNDSTECFEVHKDELTFRYLSTESMLPAACQGIIAIETRTSGEAY-DMVRAINDTEAYT 276

Query: 227 RVTAERAMNTRLEGGCQVPIGSYAELIDGEIWL---RALVGAPDGSQ-----IIRGERRG 278
           ++T ERA+ +RL  GC  PIG Y+EL    + L   +    + D  +     I R    G
Sbjct: 277 QLTCERAVLSRLNAGCHEPIGVYSELKGKHMKLSLMKVDAASSDKEKDEEIQIHRKTVEG 336

Query: 279 APQDAEQMGISLAE 292
              + EQ+  +L +
Sbjct: 337 NTSEWEQLVEALIK 350


>UniRef50_C6XST0 Porphobilinogen deaminase n=2 Tax=Pedobacter RepID=C6XST0_PEDHD
          Length = 526

 Score =  323 bits (828), Expect = 7e-87,   Method: Composition-based stats.
 Identities = 114/259 (44%), Positives = 155/259 (59%), Gaps = 8/259 (3%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             L I TR S LALWQA+++KDKL A   G+  EL  + T+GD IL+  L K+ GKG F 
Sbjct: 2   KRLIIGTRGSDLALWQANFIKDKLAAI--GVEAELKIIKTQGDKILNLRLDKLEGKGFFT 59

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRD-AFVSNNYDSLD---AL 119
           KELE  LL    DIAVHS KD+P   P GL +  + EREDP +   +  +  S++   +L
Sbjct: 60  KELEEELLGGTIDIAVHSHKDLPTVHPAGLTIAAVTEREDPSELLLILKDCVSINHKLSL 119

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG- 178
             G++VGTSS RR+ QL   RPDL I  LRGNV TR+ KL + +YDAI+LA AG+ RL  
Sbjct: 120 KKGAMVGTSSNRRKAQLLALRPDLNIEDLRGNVPTRIQKLRDEDYDAILLARAGVNRLNI 179

Query: 179 -LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237
            L       +     +PA  QGA+ I+ R +++   ++L  +NH ETA  +  ER +   
Sbjct: 180 DLSEFHVEVVDTTELVPAPAQGALAIQIRENENELFDILQQINHSETAEEIAIERKVLNL 239

Query: 238 LEGGCQVPIGSYAELIDGE 256
            EGGC +P+G Y +  DG+
Sbjct: 240 FEGGCHMPLGCYCKKEDGQ 258


>UniRef50_O29026 Probable porphobilinogen deaminase n=1 Tax=Archaeoglobus fulgidus
           RepID=HEM3_ARCFU
          Length = 289

 Score =  322 bits (826), Expect = 1e-86,   Method: Composition-based stats.
 Identities = 114/294 (38%), Positives = 167/294 (56%), Gaps = 15/294 (5%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L + TR S LAL Q + V ++L   +    VE+  + T GD++ D PL +  G G FV+ 
Sbjct: 3   LIVGTRGSKLALAQTNKVAERLKERY---EVEIRIVKTAGDIMKDKPLYEFKGMGAFVRA 59

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L+ AL E + D+AVHS KDVP +  +G  +  + ER+ P D  +S +  +L+ L  G++V
Sbjct: 60  LDTALAEGKVDVAVHSFKDVPSQRVEGTVVAAVIERDSPCDVLISRDGSTLEELDEGAVV 119

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI-R 184
           GTSSLRR+ QL+  R DL   +LRGN+ TRL KL  G YDAI++A AGLKRLGL+  +  
Sbjct: 120 GTSSLRRRAQLSRLRGDLRFENLRGNLDTRLRKLREGNYDAIVVAEAGLKRLGLDREVEY 179

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
              PPE+ +P   QG + I  R  +    +L+A LN  +T L    ERA+   L  GC V
Sbjct: 180 QPFPPEVIVPPANQGIIAIATRKGEE---DLVAFLNDEKTWLEAMVERAVIKELGVGCAV 236

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERR----GAPQDAEQMGISLAEEL 294
           P+G YAE     + L   +      + +R E +     A ++A ++G  L +E+
Sbjct: 237 PVGVYAE-AQSRVRLICEILD---KKYLRVEEKLSKDTAVEEAAEIGKDLRKEI 286


>UniRef50_D1BFI8 Hydroxymethylbilane synthase n=4 Tax=Actinomycetales
           RepID=D1BFI8_SANKS
          Length = 312

 Score =  322 bits (825), Expect = 1e-86,   Method: Composition-based stats.
 Identities = 127/310 (40%), Positives = 172/310 (55%), Gaps = 14/310 (4%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            LRI TR S LAL Q   V D L     G  VE+VP+ T GD +L   L+++GG G+FV 
Sbjct: 6   ALRIGTRSSLLALTQTGTVADDLRRL-TGRPVEIVPVTTDGD-VLTGSLSQMGGTGVFVT 63

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
            L  ALL++R D+AVHS+KD+P     GL  V    R+DPRDA  S     L  LP G+ 
Sbjct: 64  ALRAALLDDRCDVAVHSLKDLPTAGVLGLQHV-TPVRQDPRDALCSRAGHRLADLPHGAR 122

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--DNGEYDAIILAVAGLKRLGLESR 182
           VGT S RR  QL   RPDL +  +RGN+ TRL ++  + G+ DA++LA AGL R+G E  
Sbjct: 123 VGTGSPRRAAQLRLVRPDLDVVDIRGNIDTRLGRVHPETGDLDAVVLAAAGLNRIGREHA 182

Query: 183 IRAALPPEISLPAVGQGAVGIECR----LDDSRTRELLAALNHHETALRVTAERAMNTRL 238
           I   +      PA GQGA+ +E R     +D         L+   T+L V AERA+  RL
Sbjct: 183 ITELISVTDMAPAPGQGALAVETRSSLLEEDPVVARAFDQLDDPATSLSVLAERALLARL 242

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD-----AEQMGISLAEE 293
           E GC  P+G++A + DG + L A+V  PDGS+ +R  +     D     A  +G ++A+ 
Sbjct: 243 EAGCAAPVGTHATVSDGLLTLHAVVARPDGSEQLRHNQSTEVADTSTAEAVALGEAVADH 302

Query: 294 LLNNGAREIL 303
            L  GA   +
Sbjct: 303 FLALGAASFI 312


>UniRef50_Q46CH0 Probable porphobilinogen deaminase n=7 Tax=Euryarchaeota
           RepID=HEM3_METBF
          Length = 316

 Score =  322 bits (825), Expect = 1e-86,   Method: Composition-based stats.
 Identities = 113/303 (37%), Positives = 163/303 (53%), Gaps = 7/303 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG-GKGLFVK 64
           + I TR S LAL QA  V   L A   G+   L  + T GD   D PL  V  G G FV+
Sbjct: 1   MIIGTRGSQLALAQAETVARLLKAK--GVETSLKIIKTSGDRFTDRPLHAVSSGVGAFVR 58

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           EL+  +LE + DIAVHSMKD+P   P  L  V + +R+ P D  ++ +   LD L   SI
Sbjct: 59  ELDEVMLEGKIDIAVHSMKDMPTIRPPTLPTVAVLKRDTPFDLLLTYDGTPLDELSEQSI 118

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GTSSLRR  Q+   RPDL+ + LRGN+ TRL KL  G+YD I+LA AGL+R+G E    
Sbjct: 119 IGTSSLRRAAQIKRYRPDLVTQDLRGNIDTRLRKLKEGKYDGILLAKAGLERMGWELE-G 177

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L P+   P+  QG + +  R + +     ++ L+H ++ +    ER + + L GGC  
Sbjct: 178 EILSPDFFCPSPNQGTIAVVTRAE-TEAEAAVSRLDHTDSRIATEIERILISELGGGCTT 236

Query: 245 PIGSYAELIDGE--IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302
           PIGSYAE++     + +RA V + DG + +            +    L   L++ G +++
Sbjct: 237 PIGSYAEIMPDRKKLHVRAEVLSLDGEETVGINEFIPMAGGIEKARELGSSLVHMGGKKL 296

Query: 303 LAE 305
             E
Sbjct: 297 ADE 299


>UniRef50_B3RTQ8 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens
           RepID=B3RTQ8_TRIAD
          Length = 314

 Score =  322 bits (825), Expect = 2e-86,   Method: Composition-based stats.
 Identities = 120/338 (35%), Positives = 172/338 (50%), Gaps = 64/338 (18%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M + V+RI TR+S LA+ Q H V D L   HP   +E+V M T GD +LD  L ++G   
Sbjct: 4   MEETVVRIGTRKSQLAMIQTHSVVDALREIHPKARIEIVTMDTIGDRVLDKALPEIGQTN 63

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LF K+LEVAL +N+ D+ +HS+KDVP   P+GL +  I                      
Sbjct: 64  LFTKDLEVALTDNKIDLIIHSLKDVPSTLPEGLAIAAI---------------------- 101

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGL 179
            G+++GTSSLRR  QL  R P L   ++RGN+ TRL KLD  G YDA++LA AG++    
Sbjct: 102 -GNVIGTSSLRRIAQLKRRFPHLKFENVRGNLNTRLKKLDESGIYDALVLAGAGVE---- 156

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
                  L P+  L A+GQGA+GIE R +D +T  L++A    ++ +   AERA    L+
Sbjct: 157 -------LTPDECLYAIGQGALGIEIRKNDKKTFSLISAYTDFDSLVCNAAERAFLRFLD 209

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ------------------ 281
            GC VPIG Y E  + ++ +   V + DGS+ ++                          
Sbjct: 210 KGCSVPIGVYTEFTENKLKITGAVFSLDGSKRVQYSDECTISGLNAKDDCESNYESLSSI 269

Query: 282 -----------DAEQMGISLAEELLNNGAREILAEVYN 308
                      +AE++G  +AE +L N   E+LAE   
Sbjct: 270 LCPSEMCNSLIEAERLGKYVAEMILKNHGGEVLAEARQ 307


>UniRef50_B0D5Q2 Predicted protein n=1 Tax=Laccaria bicolor S238N-H82
           RepID=B0D5Q2_LACBS
          Length = 340

 Score =  322 bits (825), Expect = 2e-86,   Method: Composition-based stats.
 Identities = 120/315 (38%), Positives = 171/315 (54%), Gaps = 10/315 (3%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62
              + I  R S LA  QA  V+ +L    P    E+         I  + + + GG  L+
Sbjct: 16  QKAIVIGCRPSTLAKIQAELVRSRLKVLFPASRFEISSKKFPQPEIGTSQITERGGASLW 75

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDAL 119
             ELE AL +   DI VHS+KDVP +  +G  ++ + ERED RD  V  +   Y +L+ L
Sbjct: 76  TTELEDALFDGDIDILVHSLKDVPTKLKEGCEIIHVLEREDRRDCLVVKDGLPYRTLEEL 135

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAGLKRL 177
           PAGS+VGT S+RR  Q+  R P L+I+ +RGN+ TRL KLD+ +  Y A+ILA AGL RL
Sbjct: 136 PAGSVVGTGSVRRVAQMKRRYPLLVIKDVRGNIDTRLQKLDSPDLPYTALILASAGLLRL 195

Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237
            L  RI + L P IS PAVGQG +G E R  D++ + +++ L   +    V AERA+   
Sbjct: 196 SLHDRITSYLSPPISYPAVGQGCLGAEFRSADTKVKAMVSRLEVWQDGWAVRAERALLWV 255

Query: 238 LEGGCQVPIGSYAELIDGEIWLR--ALVGAPDGSQIIRGERRGAPQDAE---QMGISLAE 292
           LEGGC  P+G ++      I     +++ +PDGS+ I  E  G     E   ++G   A 
Sbjct: 256 LEGGCAFPVGIWSSWSGDNIASESLSVMTSPDGSEEITVETTGVVASVEEVLELGKQAAR 315

Query: 293 ELLNNGAREILAEVY 307
            LL  G R I+ ++ 
Sbjct: 316 SLLEKGGRGIIVDLR 330


>UniRef50_B9XN63 Porphobilinogen deaminase n=1 Tax=bacterium Ellin514
           RepID=B9XN63_9BACT
          Length = 332

 Score =  321 bits (824), Expect = 2e-86,   Method: Composition-based stats.
 Identities = 127/329 (38%), Positives = 172/329 (52%), Gaps = 38/329 (11%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG---K 59
           +  + IATR S LAL QA+ V  +  ++ P L +EL  + T GD +    LAK G    K
Sbjct: 6   NKPIFIATRGSALALAQANAVLSQCRSAFPKLDIELKIIKTTGDKLQKASLAKEGESLPK 65

Query: 60  GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSL--- 116
           GLF KELEVALL   ADIAVHS+KD+P E P GL L  + +R D RD  V  + + L   
Sbjct: 66  GLFTKELEVALLNGDADIAVHSLKDLPTELPTGLILGAVSKRADVRDVLVYRDAEYLRSQ 125

Query: 117 ---------------DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN 161
                             P G+ V TSS RR+ QL  +R DL +  +RGNV TRL KL N
Sbjct: 126 PGKSNRRGFTPKLAIKDFPPGATVATSSTRRKAQLLAQRGDLNVVEIRGNVATRLEKLAN 185

Query: 162 -GEYDAIILAVAGLKRLGL--------------ESRIRAALPPEISLPAVGQGAVGIECR 206
             E DA +LA AGL+RL                E  +   L  ++ LP VGQ A+G+E R
Sbjct: 186 QPELDATVLAAAGLERLNFKITAEGKLAGEGIPEGLLATILDFDVMLPCVGQAALGMEIR 245

Query: 207 LDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAP 266
            +D+R +E+   LNH ET   V AER+  + + GGCQ P+ +YAE+   ++ +RA     
Sbjct: 246 ENDARIQEICDRLNHPETHACVLAERSFLSGMGGGCQSPVAAYAEIAGDQLQMRAASFRE 305

Query: 267 DGSQIIRGERRGAPQDAEQMGISLAEELL 295
             +   R     +  +A  +G  LA +L 
Sbjct: 306 --TSARRAVGGKSINEAVALGQELAAKLK 332


>UniRef50_A0QLI0 Porphobilinogen deaminase n=69 Tax=Actinomycetales RepID=HEM3_MYCA1
          Length = 315

 Score =  321 bits (823), Expect = 2e-86,   Method: Composition-based stats.
 Identities = 133/309 (43%), Positives = 176/309 (56%), Gaps = 13/309 (4%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           ++RI TR S LA  QA  V+D L+A   G   ELV + T GD     P+  +G  G+F  
Sbjct: 1   MIRIGTRGSLLATTQAGGVRDALIAR--GHPAELVTITTAGDRS-SGPIESLG-VGVFTT 56

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
            L  A+ E R D AVHS KD+P        +  I  R DPRDA V+ +   L  LP GS+
Sbjct: 57  ALREAIEEGRVDAAVHSHKDLPTADDPRFAVAAIPARNDPRDAVVARDGLVLGELPPGSL 116

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGTSS RR  QL      L IR LRGN+ TRL+++ +G+ DAI++A AGL RLG    + 
Sbjct: 117 VGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLGDVT 176

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L P   LPA  QGA+ +ECR  DSR   +LA L+  +T   VTAERA+   LE GC  
Sbjct: 177 ETLEPVQMLPAPAQGALAVECRAGDSRLAAVLAELDDADTRASVTAERALLAELEAGCSA 236

Query: 245 PIGSYAELID---------GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295
           P+G+ AE+++          E+ LR  V A DGS +IR    G P  A ++G+S+A EL 
Sbjct: 237 PVGAIAEVVESIDEDGRIFEELSLRGCVAALDGSDVIRASGIGTPGRARELGLSVAAELF 296

Query: 296 NNGAREILA 304
             GARE+++
Sbjct: 297 ELGARELMS 305


>UniRef50_C5RMN3 Porphobilinogen deaminase n=1 Tax=Clostridium cellulovorans 743B
           RepID=C5RMN3_CLOCL
          Length = 300

 Score =  320 bits (821), Expect = 4e-86,   Method: Composition-based stats.
 Identities = 114/301 (37%), Positives = 170/301 (56%), Gaps = 8/301 (2%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +  ++RI TR+S LAL Q + V D +   HP +  E+V M T+GD ILD  L   GGKG 
Sbjct: 1   MKKIIRIGTRKSKLALMQTNIVIDAIKKKHPEINCEVVEMSTKGDEILDKSLLSFGGKGA 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS-NNYDSLDAL- 119
           FV E E A+     D+AVHS KD+P++   GL +V + +REDPRD  V+ NN D+++   
Sbjct: 61  FVSEFEKAIKSGEIDLAVHSAKDMPMDLLTGLKIVAVTKREDPRDVLVTANNKDTINDFN 120

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179
               ++GT+SLRR+ Q+     ++  + LRGNV  RL KL +GEYD IILA AGLKRLGL
Sbjct: 121 KTNKLIGTTSLRRKLQIKRLLNNVDTKDLRGNVQRRLEKLISGEYDGIILAAAGLKRLGL 180

Query: 180 ESRIR---AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236
               R     L  E  +PA GQG + +E R +      L  ++++ E    +  ER +  
Sbjct: 181 LDDERINLNYLSVEDFIPAGGQGIIAVEGRAE-EEFSFLKDSIHNEEAMYSLEVERYVMK 239

Query: 237 RLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
           +L  GC  PIG+Y+ +    I+L  ++   +G  + R +   + ++  ++   L EE+L 
Sbjct: 240 KLNAGCNEPIGAYSFIDKDTIFLD-IIYEHNGK-VSRKKGSDSIENRLKLTEKLVEEILQ 297

Query: 297 N 297
            
Sbjct: 298 E 298


>UniRef50_C1TM53 Porphobilinogen deaminase n=1 Tax=Dethiosulfovibrio peptidovorans
           DSM 11002 RepID=C1TM53_9BACT
          Length = 454

 Score =  320 bits (821), Expect = 4e-86,   Method: Composition-based stats.
 Identities = 124/289 (42%), Positives = 159/289 (55%), Gaps = 8/289 (2%)

Query: 10  TRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVA 69
           +R+S LA  Q       L     GL VE+  M T GD   D  L+  GG G FVK LE A
Sbjct: 160 SRKSALARAQTMEAARALAKK--GLPVEIKTMSTCGDEKQDCHLSAFGGNGAFVKCLEEA 217

Query: 70  LLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSS 129
           ++E + D A+HS+KDVP   P GL LV +  R    D  VSN+   L+ LPAG++VGTSS
Sbjct: 218 IMEGKGDGAIHSLKDVPSVLPDGLELVAVLPRASTSDVIVSNHKGGLEGLPAGAVVGTSS 277

Query: 130 LRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPP 189
           LRR+ QLA  RPDL    +RGNV TRL+KL +G+ DAI+LA AGL RLG+       LP 
Sbjct: 278 LRRKAQLAITRPDLDYTLIRGNVNTRLAKLQSGDADAIVLAKAGLDRLGISPEGATTLP- 336

Query: 190 EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSY 249
              LPA  QG + +E R   SR  E   A+NH  T L   AER +   L+ GC VP  + 
Sbjct: 337 --FLPAPCQGIIAVEARSG-SRLAEEFRAINHRPTWLMALAERELLESLQVGCHVPFAAL 393

Query: 250 AELIDGEIWLRALVGAPDGSQI-IRGERRG-APQDAEQMGISLAEELLN 296
           +E + GE+ LRA   + DG  I   G     +  DA  +G  +A  +  
Sbjct: 394 SEWVGGELRLRAQTLSYDGRHIDFEGSLAVRSDDDARDLGRDVALSIKA 442


>UniRef50_D2NS36 Porphobilinogen deaminase n=2 Tax=Micrococcaceae RepID=D2NS36_9MICC
          Length = 454

 Score =  320 bits (820), Expect = 5e-86,   Method: Composition-based stats.
 Identities = 134/372 (36%), Positives = 186/372 (50%), Gaps = 71/372 (19%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPG------------LVVELVPMVTRGDVI 48
           M  +   + TR S LAL Q+    + + + +              +   L  + T GD +
Sbjct: 78  MSHHEYILGTRGSALALTQSRIAAETVTSLYTEHQAHHGAADAEVVDFTLRTVKTEGD-V 136

Query: 49  LDTPLAKVGGKGLFVKELEVALLENR-------ADIAVHSMKDVPVEFPQGLGLVTICER 101
           L  PLA +GG G+F   L   LL+          D+AVHS+KD+P     GL +    +R
Sbjct: 137 LTGPLATLGGTGVFAAALRQRLLDGENASEENRVDMAVHSLKDLPSAPCPGLVIAATLKR 196

Query: 102 EDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-- 159
           EDPRDA V+ +  +LD LP GS VGT S RR  QL   RPDL I  +RGNVGTR+ ++  
Sbjct: 197 EDPRDALVARDGLTLDTLPEGSRVGTGSPRRAAQLRALRPDLEIVDIRGNVGTRIGRVKG 256

Query: 160 ----------------------------DNGEYDAIILAVAGLKRLGLESRIRAALPPEI 191
                                        +G+ DA++LAV+GLKRLG E  I   L P  
Sbjct: 257 LEEHAGKQVVLRQNTETSERADHGVGTERSGDCDAVVLAVSGLKRLGKEELITEYLDPTR 316

Query: 192 SLPAVGQGAVGIECRLD-----------DSRTRELLAAL-------NHHETALRVTAERA 233
            LPA GQGA+ +E R             D      + AL       NHHET L V+AERA
Sbjct: 317 MLPAPGQGALALEVRESEFENPDPAVLADPEVARPVRALGRALLAANHHETRLAVSAERA 376

Query: 234 MNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---AEQMGISL 290
           +  RLE GC  PIG+YA +++G++ L  +V +PDG+ ++R     A  D   AE++G+ +
Sbjct: 377 LLRRLEAGCAAPIGAYAHVVEGDLVLSVVVASPDGTDMLRHTSATAELDVPGAERLGVRV 436

Query: 291 AEELLNNGAREI 302
           AE+LL  GA  +
Sbjct: 437 AEDLLQMGAAAL 448


>UniRef50_B6W7F3 Putative uncharacterized protein n=1 Tax=Anaerococcus hydrogenalis
           DSM 7454 RepID=B6W7F3_9FIRM
          Length = 318

 Score =  319 bits (819), Expect = 6e-86,   Method: Composition-based stats.
 Identities = 106/310 (34%), Positives = 162/310 (52%), Gaps = 12/310 (3%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           +++I +R S LAL QA+ VKD L     GL  ++V + T+GD I D  + ++  KG+FV+
Sbjct: 1   MIKIGSRASKLALIQANMVKDILEKE--GLEAQIVEISTKGDRIRDRKIDQLNSKGVFVR 58

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALPAGS 123
           E+E  LL+   DIAVHS+KD+P +    L      + EDPRD FV  + +  +D L   +
Sbjct: 59  EIEEKLLDKTIDIAVHSLKDMPSQIDDRLIFTPPLKGEDPRDCFVGKDVFKKMDDL-NNA 117

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           +VGT S RR CQ      ++  +++RGNV TR+ K+ +   D +ILA +GL R GL+  I
Sbjct: 118 LVGTGSNRRVCQGKNHFSNIKFKAIRGNVETRIKKVQSENLDGVILAKSGLIRAGLDGEI 177

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              L P I  P+  QG +GIE R +D +  E+    +  +T  R+  ERA    L   C 
Sbjct: 178 NFDLDPHIFTPSPCQGILGIEIRKEDKKLFEIFKKNSDEKTLFRMETERAFQKELGADCS 237

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
            P+G + E+   +I L   +      +I      G   +     I LA++L    AR + 
Sbjct: 238 TPMGIFTEIDHDKITLTGSMAFDKDDRINYERVSGNISE----RIHLAQKL----ARTLK 289

Query: 304 AEVYNGDAPA 313
            + Y  + P 
Sbjct: 290 KKSYKKNNPC 299


>UniRef50_D1VCA1 Porphobilinogen deaminase n=1 Tax=Frankia sp. EuI1c
           RepID=D1VCA1_9ACTO
          Length = 380

 Score =  317 bits (814), Expect = 3e-85,   Method: Composition-based stats.
 Identities = 124/344 (36%), Positives = 180/344 (52%), Gaps = 44/344 (12%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           L + LR+ TR+S LAL Q+  V D+L     G+ V+LV +VT GD      ++++G  G+
Sbjct: 36  LPSRLRLGTRRSALALAQSGMVADELRTR-LGIEVDLVHVVTEGDRNR-AEISQLGSTGV 93

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           +V  L  ALL    D+AVHS+KD+P   P+G+ L  I  RED RD  VS    +L  L  
Sbjct: 94  WVSALREALLSGEVDLAVHSLKDLPTAPPEGITLAAIPPREDVRDVLVSPTGRTLAQLGP 153

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ +GT + RR  QL      L +  +RGNV TR+ K  +GE DA++LA AGL RL    
Sbjct: 154 GARIGTGAPRRAAQLRALGLGLDVVPIRGNVDTRIKKAIDGEVDAVVLARAGLARLDRLD 213

Query: 182 RIRAALPPEISLPAVGQGAVGIECRL--------------DDSR---------------- 211
            I   L PE+ LPA GQGA+ IEC                +D                  
Sbjct: 214 AITELLEPEVMLPAPGQGALAIECVATTLAPLTLLTVGTPEDQGAVTGMSCPVAPGSGVE 273

Query: 212 --TRELLA-ALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELI---------DGEIWL 259
                LL   L+   +++ V AERA    +E GC  P+G+ A+++         +GE+ L
Sbjct: 274 IPLERLLRFVLDDAPSSVAVRAERAFLAAIEAGCTAPVGALAQVLPARGQAPASEGEVRL 333

Query: 260 RALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           RA+V + DG+ ++R E  G+  D E +G  LA++LL+ GA  ++
Sbjct: 334 RAVVASLDGTTVLRRELGGSTADPEALGRRLADDLLSAGAHTLM 377


>UniRef50_UPI000174444E Hydroxymethylbilane synthase n=1 Tax=Verrucomicrobium spinosum DSM
           4136 RepID=UPI000174444E
          Length = 318

 Score =  317 bits (813), Expect = 3e-85,   Method: Composition-based stats.
 Identities = 119/307 (38%), Positives = 156/307 (50%), Gaps = 18/307 (5%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG----- 57
            + LR+ TR S LAL QA  V+  L A+HP L VE   + T GD   D   ++       
Sbjct: 6   TDTLRLGTRGSELALRQAEMVEAALHAAHPYLRVERKVIATTGDKRPDLRFSEFTEGDRL 65

Query: 58  GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD 117
            KG+F KELE+AL     DIAVHS+KDVP    +   +  +  R    D  +S    +L 
Sbjct: 66  DKGIFTKELEIALASGEIDIAVHSLKDVPTVLDEKFFIAGVLPRAPIEDVLISREGYTLA 125

Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-DNGEYDAIILAVAGLKR 176
            LPAG+ VGTSS+RR  QL    P +    +RGNV TR+ KL    + DAI+LA AGL+R
Sbjct: 126 TLPAGAKVGTSSVRRIRQLQWLNPGVECVEIRGNVPTRIRKLFAPSDLDAILLARAGLER 185

Query: 177 LGLES----------RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETAL 226
           L L                 L  E  LPA GQGA+GIE R+DD+ T E L A+NH ET  
Sbjct: 186 LSLLDGEHVVVDGQPLHAVILDCEEFLPAAGQGAIGIEARVDDAHTLEFLKAINHEETYA 245

Query: 227 RVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPD--GSQIIRGERRGAPQDAE 284
           RVTAER     L+ GCQ PIG++  L +G + ++  V      G               +
Sbjct: 246 RVTAEREFLHILKAGCQTPIGAHTFLENGVLQMKVRVFDETDPGRPPKEVTSTEPYHSPK 305

Query: 285 QMGISLA 291
            +   +A
Sbjct: 306 GLAAEVA 312


>UniRef50_C6R3Y0 Hydroxymethylbilane synthase n=1 Tax=Rothia mucilaginosa ATCC 25296
           RepID=C6R3Y0_9MICC
          Length = 377

 Score =  317 bits (813), Expect = 4e-85,   Method: Composition-based stats.
 Identities = 134/372 (36%), Positives = 187/372 (50%), Gaps = 71/372 (19%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPG------------LVVELVPMVTRGDVI 48
           M  +   + TR S LAL Q+    + + + +              +  EL  + T GD +
Sbjct: 1   MSHHEYTLGTRGSALALTQSRIAAETVTSLYTEHQAHHGAENPEAVSFELRTVKTEGD-V 59

Query: 49  LDTPLAKVGGKGLFVKELEVALLENR-------ADIAVHSMKDVPVEFPQGLGLVTICER 101
           L  PLA +GG G+F   L   LL+          D+AVHS+KD+P     GL +    +R
Sbjct: 60  LTGPLATLGGTGVFAAALRQRLLDGENASEENRVDMAVHSLKDLPSAPCPGLVVAATLKR 119

Query: 102 EDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-- 159
           EDPRDA V+ +  ++D LP GS VGT S RR  QL   RPDL I  +RGNVGTR+ ++  
Sbjct: 120 EDPRDALVARDGLTVDTLPEGSRVGTGSPRRAAQLRALRPDLEIVDVRGNVGTRIGRVKG 179

Query: 160 ----------------------------DNGEYDAIILAVAGLKRLGLESRIRAALPPEI 191
                                        +G+ DA++LAV+GLKRLG E  I   L P  
Sbjct: 180 LEEHAGKQVVLRQNAETSERADHGVGTERSGDCDAVVLAVSGLKRLGKEELITEYLDPTR 239

Query: 192 SLPAVGQGAVGIECRLD-----------DSRTRELLAAL-------NHHETALRVTAERA 233
            LPA GQGA+ +E R             D      + AL       NHHET L V+AERA
Sbjct: 240 MLPAPGQGALALEVRESEFENPDSAVLADPEVARPVRALGRALLAANHHETRLAVSAERA 299

Query: 234 MNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---AEQMGISL 290
           +  RLE GC  PIG+YA +++G++ L  +V +PDG+ ++R     A  D   AE++G+ +
Sbjct: 300 LLRRLEAGCAAPIGAYAHVVEGDLVLNVVVASPDGTDMLRHTSATAELDVPGAERLGVRV 359

Query: 291 AEELLNNGAREI 302
           AE+LL  GA  +
Sbjct: 360 AEDLLQMGAAAL 371


>UniRef50_B6JII8 Porphobilinogen deaminase n=11 Tax=Bradyrhizobiaceae
           RepID=B6JII8_OLICO
          Length = 338

 Score =  317 bits (812), Expect = 4e-85,   Method: Composition-based stats.
 Identities = 112/323 (34%), Positives = 161/323 (49%), Gaps = 18/323 (5%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           + D  +RI TR+S +AL Q   +  +L A+ P L VE+V   T GD      L  +GGKG
Sbjct: 9   VTDKAMRIGTRKSVMALAQTSEIARQLTAADPALDVEIVKFETTGDQDQTGKLLDLGGKG 68

Query: 61  -LFVKELEVALLENRADIAVHSMKDVPV-EFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118
             FV ++  A+ E R + A+HS+KD+P  E   GL +     R+ P DA V  +  +L  
Sbjct: 69  GAFVAQIRDAVREGRLEAAMHSLKDMPGNEDTPGLVIGATLTRDPPTDALVVRHGVTLAD 128

Query: 119 L----PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE----------- 163
           L      G  +GT+++RR   +    P+  I   RG   TR+ KLDNGE           
Sbjct: 129 LRRTGGKGFKIGTNAVRRAAYVRRLFPECEIIHFRGAADTRIRKLDNGEKQRLPEGGEVG 188

Query: 164 -YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHH 222
             DA+++A AGL+R+G   RI     P+  LPAVGQG V +EC   D  T   LA ++  
Sbjct: 189 PADALVMAQAGLERVGCADRIAHCFSPDEILPAVGQGIVAVECAASDWCTLARLAQIDDP 248

Query: 223 ETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD 282
            +     AER +   L G C  PI  YA +   ++ L+A V        I   RRG    
Sbjct: 249 VSRCCAAAEREVLWVLNGHCNSPIAGYAIVEGDDVLLKAAVLDEANDHFIEVTRRGPASR 308

Query: 283 AEQMGISLAEELLNNGAREILAE 305
             ++G ++A ELL  GA +++A 
Sbjct: 309 PRELGRAVAFELLAKGAADVIAR 331


>UniRef50_C2FZW8 Porphobilinogen deaminase n=2 Tax=Sphingobacterium spiritivorum
           RepID=C2FZW8_9SPHI
          Length = 528

 Score =  316 bits (811), Expect = 6e-85,   Method: Composition-based stats.
 Identities = 112/311 (36%), Positives = 158/311 (50%), Gaps = 24/311 (7%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           ++  L I TR S LA+WQA+++KD+L A+  G+  EL  + T+GD+I    L K+ GKG 
Sbjct: 1   MNRKLIIGTRGSQLAMWQANHIKDRLAAA--GIDSELKVIKTQGDIIQHLRLDKLEGKGF 58

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY----DSLD 117
           F KELE  LL +  D+AVHS KD+P   P GL +  + ERE P +  +            
Sbjct: 59  FTKELEEELLSSTIDLAVHSHKDLPTVNPPGLIIAAVSERESPAELLIVLKDCVDIKKRL 118

Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKR- 176
           +L   + VGTSS RR+ QL   RPDL    LRGN+ TR+ KL +  YDAIILA AG++R 
Sbjct: 119 SLKHNATVGTSSNRRKAQLLSLRPDLEFDDLRGNLQTRIQKLRDENYDAIILAKAGVERI 178

Query: 177 -LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235
            + L       +PP   +PA  QG + I+ R  D    E L  +++ E A  +  ER + 
Sbjct: 179 DMDLSDFYVEEIPPVELIPAPAQGVLAIQIRESDQELFEALQVIHNKEVAEVIAVERKVL 238

Query: 236 TRLEGGCQVPIGSYAELIDGEIWLRALVGA-----PDGSQIIRGERRGAPQDAEQMGISL 290
              + GC  P+G Y    +G+      V       PD   I R    G           +
Sbjct: 239 NLFDAGCHAPLGCYCRKSEGKYEAWTSVAETSDEFPDRLYIQRDSTEG-----------M 287

Query: 291 AEELLNNGARE 301
           AEE+    A++
Sbjct: 288 AEEIFTKFAKD 298


>UniRef50_A8AAB4 Probable porphobilinogen deaminase n=1 Tax=Ignicoccus hospitalis
           KIN4/I RepID=HEM3_IGNH4
          Length = 304

 Score =  316 bits (811), Expect = 6e-85,   Method: Composition-based stats.
 Identities = 113/294 (38%), Positives = 158/294 (53%), Gaps = 7/294 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILD--TPLAKVGGKGLFV 63
           ++IA R S L+L Q       L+   P L  E++ + T GD        LAK G  GLF 
Sbjct: 3   IKIAARGSKLSLKQVSMFTSYLLKFFPDLEYEVITVKTTGDKANAPFEELAKRGLTGLFE 62

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD-SLDALPAG 122
           KE+  A+LE +AD+AVHS+KD+P E    L +     R+ P D  +S   +  +  LP G
Sbjct: 63  KEVNKAVLEGKADVAVHSLKDLPTELDPRLEIAAFLPRDPPYDVLISRAGNYDIFDLPKG 122

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           S+VGTSS RR+  +   RPDL+++ LRGNV TRL KL  GEYDAI+LA AG+ RLGL + 
Sbjct: 123 SVVGTSSARRKALIKNLRPDLVVKDLRGNVDTRLEKLRRGEYDAIVLAEAGVSRLGL-NV 181

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
               L   +  P+ GQG +    R   S   +LL +++  ++    TAER +     GGC
Sbjct: 182 DYVRLDWRLFPPSPGQGIIVAVTRKG-SEISDLLKSISDVKSEKLATAERTVLKEFGGGC 240

Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
            V +G+ A      I LRA V +P G + +  E  G     E++G+  AE L  
Sbjct: 241 FVALGAIAFEEGSLIRLRATVLSPSGRERVDVELIGKG--PEEVGMRAAERLKA 292


>UniRef50_C9M5W1 Hydroxymethylbilane synthase n=1 Tax=Jonquetella anthropi E3_33 E1
           RepID=C9M5W1_9BACT
          Length = 714

 Score =  316 bits (810), Expect = 7e-85,   Method: Composition-based stats.
 Identities = 116/297 (39%), Positives = 161/297 (54%), Gaps = 7/297 (2%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           L   LR+A+R+S LA+ Q+  V ++L  +  G  VE++P  TRGD + D  L   GGKGL
Sbjct: 422 LGRPLRLASRESELAMAQSRLVAERLHEA-TGFDVEIIPFRTRGDAVADRRLESAGGKGL 480

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FVKELE A+L  +AD+AVHS+KD+P   P GL    + +R+   D  V     +   +  
Sbjct: 481 FVKELERAILSGQADLAVHSLKDMPSSCPDGLAFAALMDRQTAFDCLVLRPGLTGRPV-- 538

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
              +GTSS RR  Q      D     LRGN+ TRLSKLD GE+DA+ILA AGL+RLGL+ 
Sbjct: 539 --RIGTSSARRIAQGRALFSDAQFVPLRGNLRTRLSKLDGGEFDALILAEAGLRRLGLQE 596

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
           R+      +  +P+ GQG + ++C  D     +L++ L+         AERA   RL GG
Sbjct: 597 RVSRVFSADQMIPSAGQGTLAVQCPFDGP-VFDLVSQLDEPAVRTCCLAERAFIDRLNGG 655

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
           C  P G+YA +    I +  L   PDG   + G+  G   D   +   LA+ L   G
Sbjct: 656 CTAPHGAYARVDGETIEMIGLYVRPDGKT-LSGKISGPAADGPSLAAELADRLKRRG 711


>UniRef50_Q1EPC8 Porphobilinogen deaminase, chloroplast (Hydroxymethylbilane
           synthase) (Pre-uroporphyrinogen synthase), putative n=1
           Tax=Musa acuminata RepID=Q1EPC8_MUSAC
          Length = 328

 Score =  316 bits (810), Expect = 8e-85,   Method: Composition-based stats.
 Identities = 126/296 (42%), Positives = 163/296 (55%), Gaps = 34/296 (11%)

Query: 11  RQSPLALWQAHYVKDKLMASHPGLV----VELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66
           R S LAL QA   +DKL A+H  L     VE++ + T GD+ILD PLA +GGKGLF KE+
Sbjct: 54  RDSDLALAQARETRDKLKAAHSELAEEGAVEIIIIKTTGDMILDKPLADIGGKGLFTKEI 113

Query: 67  EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126
           + ALL+ R DIAVHSMKDVP   P+G  L                               
Sbjct: 114 DDALLQGRIDIAVHSMKDVPTYLPEGTILPCNLP-------------------------- 147

Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAA 186
            +SLRRQ Q+  R P L + +LRGNV TRL+KL NG+  A +LA+AGLKRL +   + + 
Sbjct: 148 -ASLRRQSQILCRYPSLKVVNLRGNVQTRLTKLKNGDVHATLLALAGLKRLNMVENVTSI 206

Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246
           L  E  LPAV QGA+GI CR +D++  E L++LNH +T   V  ER   T L+G C+ PI
Sbjct: 207 LSMEEMLPAVAQGAIGIACRSNDNKMMEYLSSLNHEDTRSAVACEREFLTVLDGNCRTPI 266

Query: 247 GSYAELI-DGEIWLRALVGAPDGSQIIRGERRGA--PQDAEQMGISLAEELLNNGA 299
            +YA    DG    R L+ +PDGS++    R G     D  +MG     EL     
Sbjct: 267 AAYAHRDKDGSCSFRGLLASPDGSKVYETTRIGPYSFDDMVEMGKDAGHELKAKAG 322


>UniRef50_Q57989 Probable porphobilinogen deaminase n=11 Tax=Methanococcales
           RepID=HEM3_METJA
          Length = 292

 Score =  315 bits (808), Expect = 1e-84,   Method: Composition-based stats.
 Identities = 106/297 (35%), Positives = 158/297 (53%), Gaps = 10/297 (3%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           ++RI TR S LAL+QA+ V + L   + G  VE+  + T GD +LD  L+ +G  G+F K
Sbjct: 1   MIRIGTRGSKLALYQANKVAELLK--NLGYKVEIKIIKTTGDRVLDKKLSDIG-IGVFTK 57

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           EL++A+L N  DIAVHS+KD+P  + + L +  + ER+   D  + N     +   +  +
Sbjct: 58  ELDLAMLNNEIDIAVHSLKDIPTIWNENLMVGAVLERDSYHDLLIWNKDIDFNE-DSKIV 116

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GTSS+RR+  L    P+     LRGNV TRL KL  G YDAI+L+ AG+ RLG+     
Sbjct: 117 IGTSSMRRRAFLKFIYPNAKFELLRGNVDTRLRKLKEGLYDAIVLSEAGIIRLGVSLEDF 176

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
                +I LPA  QG + + C+ DD   + +L  +NH  T L    ER       GGC V
Sbjct: 177 NYKRLDI-LPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSV 235

Query: 245 PIGSYAELIDGE--IWLRALVGAPDGSQIIRGERRGAPQD---AEQMGISLAEELLN 296
           P G+ A   +    + L+A V   D  +   GE +    +   A ++G  +  +L N
Sbjct: 236 PFGALAVYDEKNELLKLKAAVVTNDELKNASGEVKCKIDEIDKAVELGKKIGLKLKN 292


>UniRef50_D2RH82 Porphobilinogen deaminase n=2 Tax=Archaeoglobaceae
           RepID=D2RH82_ARCPR
          Length = 292

 Score =  315 bits (807), Expect = 2e-84,   Method: Composition-based stats.
 Identities = 111/296 (37%), Positives = 166/296 (56%), Gaps = 11/296 (3%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   + + TR S LAL Q   V ++L     G  VE+  + + GD++ D PL +  G G 
Sbjct: 1   MSERVVVGTRGSKLALAQTSKVVERLKEE--GYSVEIRIIKSTGDIMKDKPLYEFKGSGA 58

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FV+ LE AL+    D+AVHS KD+P    +G+ +  + ER+ P DAF++ N +SL+ +  
Sbjct: 59  FVRALEHALVRGEIDVAVHSYKDIPSNMLEGVTVSAVLERDSPYDAFIARNGESLEEIKP 118

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
            +++GTSSLRR+ QL   R DL   +LRGNV TRL KL  G YDAI+LA AG++RLGL  
Sbjct: 119 NAVIGTSSLRRRAQLKLYRSDLRFENLRGNVDTRLRKLREGLYDAIVLAEAGIQRLGLNV 178

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
           +    LP E  +P   QG + ++ R+ +    +L+  +NH ET +    ER +   L  G
Sbjct: 179 K-YQRLPIERFVPPANQGIIAVQTRVGEE---DLVKFMNHEETWIEAEVERIVMKTLGVG 234

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQ---IIRGERRGAPQDAEQMGISLAEEL 294
           C +P G YAE   G++ L   V   DG +   I    R  A ++A ++  +  EE+
Sbjct: 235 CAIPAGIYAECR-GKVRLIVQVIR-DGREFKVIEELSRESAIEEAREIAENFREEV 288


>UniRef50_Q2NEP4 HemC n=4 Tax=Methanobacteriaceae RepID=Q2NEP4_METST
          Length = 290

 Score =  314 bits (805), Expect = 3e-84,   Method: Composition-based stats.
 Identities = 91/292 (31%), Positives = 149/292 (51%), Gaps = 4/292 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           + + TR S LA  Q   V   L     G  +E   + T GD I ++ L  +  KG+F KE
Sbjct: 1   MIVGTRGSKLATTQTKTVVKALEEIT-GEEIETKIIKTTGDKIKNSQLYNIDAKGIFTKE 59

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L+ AL++   D AVHS KD+P E    L +  I +RE   +  +SN   S D LP  + +
Sbjct: 60  LDTALIDGSIDFAVHSFKDLPSELNDQLTITAIPQREAINEVLISNY--SWDELPENATL 117

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS+RR+         +  + +RGN+ TR+ K++ GEYDA I+A+AG+ RLGL+  I+ 
Sbjct: 118 GTSSVRREAFCKLHGKKIQTKPIRGNIDTRIRKVEEGEYDATIMALAGINRLGLQEHIKE 177

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
               +   P  GQGA+ +     DS   ++++ LNH ++ +    E+A+   +  GCQ P
Sbjct: 178 VFDEQYITPPAGQGALAVMTHK-DSEYNDVISKLNHEDSRIEAMTEKAILETIGVGCQWP 236

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           IG  +++    I +   + +P+G  +    +     +A      +  +L  +
Sbjct: 237 IGIVSKVDGNNINIHCKLLSPEGKLLADVNKTTDKNNAINTAKVIGTKLRED 288


>UniRef50_A4WN24 Probable porphobilinogen deaminase n=3 Tax=Thermoproteaceae
           RepID=HEM3_PYRAR
          Length = 297

 Score =  313 bits (804), Expect = 4e-84,   Method: Composition-based stats.
 Identities = 110/293 (37%), Positives = 157/293 (53%), Gaps = 6/293 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L +ATR S L++ Q   +  ++ A  P +  E+  + T GD + D PL ++G KG+F KE
Sbjct: 3   LVVATRGSKLSMLQTEELLAQIKAVEPSIEFEIKIVKTTGDEVQDKPLYQIGVKGIFEKE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           + +A+L   AD+AVHS+KD+P E   GL L    +R  P DA VS     L+ LP G++V
Sbjct: 63  VNLAVLRGEADVAVHSLKDLPSELSPGLVLAGFSKRAPPFDAVVSTAGYVLETLPRGALV 122

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL-GLESRIR 184
           GTSS+RR   +   RPD+ +  LRGNV TR++K+  G+YDA I+AVAG+ RL G    I+
Sbjct: 123 GTSSVRRAEFVKAIRPDVRVEPLRGNVDTRINKILQGKYDAAIMAVAGIYRLYGASPPIK 182

Query: 185 -AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
            A L PE+  P  GQG V    R  DS   +LL   +  + +L   AER     +  GC 
Sbjct: 183 LAVLRPEVLPPPPGQGIVAAVVREADSWLIDLLKKASDPKASLEAIAEREFLKAVGAGCH 242

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
           V IG  A   +  +   A   +  G +       G   D  ++G   AEE+  
Sbjct: 243 VAIGGVAFARNDTVEFIAGYAS--GGRKYIVRVVG--DDPVEVGRRAAEEIRK 291


>UniRef50_C0BZ93 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM
           15053 RepID=C0BZ93_9CLOT
          Length = 298

 Score =  312 bits (800), Expect = 1e-83,   Method: Composition-based stats.
 Identities = 120/297 (40%), Positives = 163/297 (54%), Gaps = 7/297 (2%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           + +++RI +R+S LA+ QA  VK  +  + P +  E+V M T GD ILD  L   GGKGL
Sbjct: 1   MQSIIRIGSRESRLAVKQAEIVKQAVERNCPDIKAEIVTMKTEGDKILDRRLELAGGKGL 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FVKELE ALL+ R DI VHS+KDVP+E P+ L +V   EREDPRD  +     +  ++P 
Sbjct: 61  FVKELEKALLDGRIDICVHSLKDVPMEVPEDLPVVAFGEREDPRDVLIYKPGRT--SIPE 118

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G ++GTSS RR+ QL    P    RS+RGNV TRL KL    +D  +LA AGLKRL +E 
Sbjct: 119 GGVIGTSSRRRELQLKRLYPSCTFRSIRGNVQTRLRKLSEEGFDGTVLAAAGLKRLHMEE 178

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
                   +  +PAVGQG + ++ R         L +    ++     AER     L GG
Sbjct: 179 VAGRVFSVDEIIPAVGQGILAVQGRKGRDY--SWLTSFACGKSRAEAEAEREFAAALGGG 236

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRG-ERRGAPQDAEQMGISLAEELLNN 297
           C  P+ ++A+    E+ L  L     G  I R   R G    A Q+G +LAEE+   
Sbjct: 237 CTSPVAAHAQAQGAELKLTGLYYC--GGDIYRTRTRTGETDRARQLGAALAEEMRRE 291


>UniRef50_A1DGB8 Porphobilinogen deaminase n=1 Tax=Neosartorya fischeri NRRL 181
           RepID=A1DGB8_NEOFI
          Length = 363

 Score =  312 bits (799), Expect = 1e-83,   Method: Composition-based stats.
 Identities = 120/344 (34%), Positives = 164/344 (47%), Gaps = 39/344 (11%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKL-MASHPGLVVELVPMVTRGDVILDTPLAKVG---- 57
           + V+    R+S LAL Q  +V  KL     P    ++      GD     P A +     
Sbjct: 20  EEVVIFGCRKSELALVQTRWVTSKLGQTLDPSPTFQIATGSAVGDADKQAPFAVLSKLTG 79

Query: 58  ----GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN-- 111
               GK L+  ELE+ L+  +    VHS+KD+P   P    L  + ERED  DA      
Sbjct: 80  GSDIGKSLWTNELELDLVAGKVHCLVHSLKDMPTTLPPHCLLGAVPEREDCSDAVCMRSD 139

Query: 112 -NYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAII 168
             + S+D LP GSIVGTSS RR+  +    P L +   RGNV TRL+KLD  +  +  I+
Sbjct: 140 LKFTSIDQLPPGSIVGTSSSRRKALVRRNWPHLEVVECRGNVDTRLAKLDAPSSRFSCIL 199

Query: 169 LAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRV 228
           LA AGL RLGL  RI   L   I   AVGQGA+G+E   D     EL+  ++H  +  R 
Sbjct: 200 LATAGLLRLGLGHRITHRLDDSIFPYAVGQGALGLEVSTDRPDILELVRHVDHKPSRWRG 259

Query: 229 TAERAMNTRLEGGCQVPIGSYAELI----------------------DGEIWLRALVGAP 266
            AERAM   L+GGC  PIG  + L                        G + LRA+V   
Sbjct: 260 IAERAMLRSLQGGCSSPIGVQSSLEPLGKEENGSTEDDSQRGRDSSSGGNLSLRAMVLHI 319

Query: 267 DGSQIIRGERRGAP---QDAEQMGISLAEELLNNGAREILAEVY 307
           +G+  I  E        ++AE +G+S+A  LL  GAR ++ + +
Sbjct: 320 EGTSEIVAEDMATVRCDEEAELLGVSVANMLLAKGARGLMPKQF 363


>UniRef50_C5CB88 Porphobilinogen deaminase n=5 Tax=Actinomycetales RepID=HEM3_MICLC
          Length = 377

 Score =  311 bits (798), Expect = 2e-83,   Method: Composition-based stats.
 Identities = 130/356 (36%), Positives = 180/356 (50%), Gaps = 61/356 (17%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           + LRI TR S LA  Q  +V + L A   GL  ELV + T GD +    LA +GG G+F 
Sbjct: 2   SPLRIGTRGSALATTQTSHVAEALTARS-GLAHELVVIRTEGD-VTTGSLASLGGTGVFA 59

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
             L  A+L+   D AVHS+KD+P   P+ L +  +  R D RDA  + +  +L  LP G+
Sbjct: 60  SALRAAVLDGVVDAAVHSLKDLPAAQPETLEIAAVPARADLRDALCARDGLTLATLPEGA 119

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL----------------DNGEYDAI 167
            VGT S RR  QL   RPDL +  +RGNV TRL+++                  G+ DA+
Sbjct: 120 RVGTGSPRRVAQLKALRPDLELVDIRGNVQTRLARVPGLEQHDDHAPAAVGSPRGDLDAV 179

Query: 168 ILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDS---------------RT 212
           ILA AGL RLGL+  I   + PE+ +PA GQGA+ +E R +D                R 
Sbjct: 180 ILACAGLDRLGLDHVITERIDPEVMVPAPGQGALAMEIRAEDESFLGRALLDPEAPVGRL 239

Query: 213 RELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGE-----IWLRALVGAPD 267
              L  ++  +T + VTAERA+  RLE GC  PIG+ A + DGE     I + A+V A D
Sbjct: 240 HAALELVDDRDTHVAVTAERALLRRLEAGCAAPIGAVARVGDGEAGAPRIEMTAMVAALD 299

Query: 268 GSQIIR-----------GERRGAPQ------------DAEQMGISLAEELLNNGAR 300
           GS+++R            +  G P              AE +G+ +AE+ +  GA 
Sbjct: 300 GSRVLRRTSSVQLDPVPADVVGDPAAADEWLEDTLFVAAEALGVHVAEQFVAEGAD 355


>UniRef50_D1C4S0 Porphobilinogen deaminase n=1 Tax=Sphaerobacter thermophilus DSM
           20745 RepID=D1C4S0_SPHTD
          Length = 311

 Score =  308 bits (789), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 122/289 (42%), Positives = 158/289 (54%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +R+ TR S LA  Q   V   L A  P L +    + T GD    TPL  +GG+G+F +E
Sbjct: 11  VRLGTRGSALAREQTRRVMAALAALRPDLELIETIVSTAGDRDKRTPLTVIGGQGVFARE 70

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L+ ALL    D+AVHS KD+P E   GL +     RED RD  VS +  SL  LP G+ V
Sbjct: 71  LQTALLAGTVDVAVHSAKDLPTEPVPGLVIGAFFSREDARDVLVSRDGRSLADLPPGARV 130

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS RR   L   RPDL    LRGN+ TRL K+  GE DA ILA AGL R+G +  I  
Sbjct: 131 GTSSRRRLVALRRLRPDLEAVDLRGNLDTRLRKVREGEVDAAILAAAGLLRMGWQEHITE 190

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L  +  +PA GQGA+ IECR DD    E+LAALN    AL    ER+    L GGC+ P
Sbjct: 191 FLSLDDFVPAPGQGALAIECRADDPAVNEMLAALNDPAAALAARTERSFLRALGGGCRSP 250

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
           IG++A +    + LR ++G    +++          +AE    +LA E+
Sbjct: 251 IGAHATVSGDTVTLRVMLGDEAMTRVRLSTWTLPAAEAETRAGALAVEV 299


>UniRef50_O26960 Probable porphobilinogen deaminase n=1 Tax=Methanothermobacter
           thermautotrophicus str. Delta H RepID=HEM3_METTH
          Length = 289

 Score =  307 bits (788), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 104/286 (36%), Positives = 155/286 (54%), Gaps = 4/286 (1%)

Query: 9   ATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEV 68
            TR S LAL Q ++V + L +      +E   + T+GD I D+ L  +  +GLF +EL++
Sbjct: 4   GTRGSRLALVQTNHVIEML-SEVCKEKIEKKIIKTKGDRIRDSQLYSMDSRGLFTRELDM 62

Query: 69  ALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTS 128
           A+L    D+AVHS+KDVP +    L +  +  RE P +  VS      + LP GS +GTS
Sbjct: 63  AVLNEEVDLAVHSLKDVPSDLDPDLAIAAVPPRESPAEVLVSR--LDWEDLPQGSKLGTS 120

Query: 129 SLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALP 188
           SLRR+      + +  +  LRGN+ TR+ K+ +GE  A I+A AGLKRLGLE  I+   P
Sbjct: 121 SLRREAFCNHHQKNFKMEPLRGNIDTRIRKVMDGEVHATIMAEAGLKRLGLEEHIKRRFP 180

Query: 189 PEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGS 248
            E   PA GQGA+ +  R  DS     +  + HH +   VTAE+ +   L  GCQ P+G 
Sbjct: 181 VEYFTPAAGQGALAVITRA-DSELISSIGRITHHPSLQEVTAEKTLLRELGAGCQCPLGV 239

Query: 249 YAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
                  ++ L A++   +G  + +   RG   +AE +G   A+E+
Sbjct: 240 IGRATGNQLTLYAVLLTREGEMLRKVTVRGPLAEAEDIGKKAAKEM 285


>UniRef50_UPI0001BC2D4C glutamyl-tRNA reductase n=1 Tax=Brevibacterium linens BL2
           RepID=UPI0001BC2D4C
          Length = 825

 Score =  307 bits (787), Expect = 3e-82,   Method: Composition-based stats.
 Identities = 115/333 (34%), Positives = 171/333 (51%), Gaps = 30/333 (9%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
               +R+ TR+S LA  Q+  +  +L A+  G  VE+V +VT GDV + +PL   GG G+
Sbjct: 475 SGRTIRLGTRRSKLARSQSTAIAHQL-AALTGWRVEIVEVVTEGDVNM-SPLTGFGGTGV 532

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FV  +  AL + + DIAVHS+KD+P     G+ +  I  R DP D  +  +  S   LPA
Sbjct: 533 FVSAVRQALHQGKIDIAVHSLKDLPTTPEAGIQMAAIPPRVDPADVLIGRDGLSFAELPA 592

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           GS+VGT S RR  QL   RPD+ +R +RGNV TR++ + +G  DA++LA AG++R+G  +
Sbjct: 593 GSVVGTGSPRRAVQLRAARPDIEVRGVRGNVDTRIAHVRDGRLDAVVLAAAGVRRIGRLA 652

Query: 182 RIRAALPPEISLPAVGQGAVGIECR-------------LDDSRTRELLAALNHHETALRV 228
               +L  +  LPA GQGA+ +E R               D+  R  L  L+   T L V
Sbjct: 653 EATDSLDFDTMLPAPGQGALAVETRGADSPFALDNEVMEADAEVRTQLKRLHDETTDLAV 712

Query: 229 TAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER------------ 276
           T ERA+ +R E GC  PIG+ A +   +  + A++   DG      +             
Sbjct: 713 TCERAILSRAEAGCSAPIGALATIQGSDFVVDAVMADDDGKLARTRQVAPLPTTPDVDLD 772

Query: 277 RGAPQDAEQMGIS---LAEELLNNGAREILAEV 306
            G+       G     LA+EL    A ++L ++
Sbjct: 773 SGSANQLSITGKELARLADELGTAAAEDLLGQL 805


>UniRef50_Q6AHF1 Porphobilinogen deaminase n=5 Tax=Actinobacteria (class)
           RepID=HEM3_LEIXX
          Length = 329

 Score =  304 bits (780), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 115/311 (36%), Positives = 159/311 (51%), Gaps = 15/311 (4%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            LR+ TR SPLA+ Q   V   +  +  G  +ELV + T GD   ++ L+++GG G+F  
Sbjct: 14  ALRVGTRGSPLAVAQTQAVSAAVARA-TGFDIELVTVTTHGDTSRES-LSELGGTGVFAT 71

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
            L  AL     D+ VHS+KD+P     GL L  + +R D RD   + +      LP G+ 
Sbjct: 72  ALRDALRNGECDLVVHSLKDLPTAPAPGLVLGAVPKRADARDTLCARDGLRFGELPEGAS 131

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGT S RR  QL  +RP L I  +RGNV TRLS++  G+ DA++LA AGL RLG      
Sbjct: 132 VGTGSPRRAAQLRAQRPGLDIVDIRGNVDTRLSRVSAGDLDAVVLAAAGLGRLGRLDAAT 191

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSR----TRELLAALNHHETALRVTAERAMNTRLEG 240
                     A GQGA+ +E R  D R        LAA++H  T    TAERA+   LE 
Sbjct: 192 DFFSLSTMPTAPGQGALALEVREGDERGRGPIARALAAVDHATTCAATTAERAVLAGLEA 251

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---------AEQMGISLA 291
           GC  P+G+ A + DG ++L A V  PDG+  +       P           A  +G  + 
Sbjct: 252 GCAAPVGATAMIDDGLLFLTATVYRPDGAAQLTASHAATPDSFGAAHLDEAARDVGERVV 311

Query: 292 EELLNNGAREI 302
            ELL +GA ++
Sbjct: 312 AELLASGAADL 322


>UniRef50_C6V4N6 Porphobilinogen deaminase n=2 Tax=Neorickettsia RepID=C6V4N6_NEORI
          Length = 286

 Score =  304 bits (780), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 113/292 (38%), Positives = 163/292 (55%), Gaps = 9/292 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L++  R S LAL QA  V+  L      +   LV + T GD++ D PL +VGGK LF+KE
Sbjct: 4   LKVGARCSTLALAQARLVERALAPYCERID--LVGVRTSGDILSDIPLTEVGGKALFLKE 61

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           LE  LL    DIAVHSMKDVP  +   L +V + +R  P D FVS  Y ++ +LP+G+++
Sbjct: 62  LEEKLLTGEIDIAVHSMKDVPAFYHDDLEVVPVLKRAIPNDVFVSFRYPNMLSLPSGAVI 121

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GT + RR  QL +R     +  LRGN+ TR+ K  N   D IILA  GL+RLGL   I  
Sbjct: 122 GTCAPRRVVQLNQRF---RVIPLRGNIATRVEKAKN--LDGIILAFCGLERLGLCKMISE 176

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            +  ++ LP V QGA+ +E R  D   REL+  ++  ET +  TAERA    + G C+  
Sbjct: 177 VIHEDVMLPGVAQGALCVEFRKKDHFLRELILNISDRETIICTTAERAFLEEINGDCKTA 236

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           +G+ A + +  ++   ++G  +     R    G+  +A+Q+G S A  LL  
Sbjct: 237 LGALAVVKNNTLYFTGMLGKDNRPCYFRTS--GSCLNAKQIGRSAALALLRM 286


>UniRef50_C9RPT6 Porphobilinogen deaminase n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RPT6_FIBSS
          Length = 351

 Score =  303 bits (777), Expect = 5e-81,   Method: Composition-based stats.
 Identities = 130/346 (37%), Positives = 172/346 (49%), Gaps = 57/346 (16%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHP-------------GLVVELVPMVTRGDV 47
           M D  LRIATR+S LAL Q     D ++A++               L  ELV M T GD 
Sbjct: 1   MSDLKLRIATRKSALALAQTTMAADAIVAANSVIGNAADSNNARDSLTYELVSMTTEGDR 60

Query: 48  ILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDA 107
            LD  LA  GGKG+F+KELE+ALLE RADIA+HS+KD+P E      L  + +REDPRDA
Sbjct: 61  RLDKSLASFGGKGVFIKELEIALLEGRADIAIHSLKDMPAEVLPQFKLAAVLKREDPRDA 120

Query: 108 FVSNNYD---SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY 164
           F+S           LPAG+ VGT S+RR  QL   RPDL    +RGN+ TR+ KL   E 
Sbjct: 121 FLSRGGSAGIRFMDLPAGARVGTGSIRRVVQLKALRPDLEYVPIRGNIQTRIGKLA--EL 178

Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLD----------DSRTRE 214
           D ++LA AGLKR+GL  ++      E  LPA GQG + IE   D           +   +
Sbjct: 179 DGVVLAAAGLKRMGLADQVTEYFSTEQMLPASGQGILAIETLNDATVQESRVTGRADLAQ 238

Query: 215 LLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELI--DG----------------- 255
           +LA +N   T    +AE A    L  GCQ P+ S+AE +  DG                 
Sbjct: 239 ILARVNDVATYCIASAEMAYLKALNAGCQFPVASFAEFVCEDGIENRGTCGALEENANRI 298

Query: 256 --EIWLRALVGAPDGSQIIRGERRGAPQ--------DAEQMGISLA 291
              + +R +       +++R E  G            ++ +GI LA
Sbjct: 299 AQTLKIRGIYWDEKSEKLLRAEVAGNVDLNSEDCVQQSKNLGIELA 344


>UniRef50_Q6L2G8 Probable porphobilinogen deaminase n=1 Tax=Picrophilus torridus
           RepID=HEM3_PICTO
          Length = 282

 Score =  303 bits (777), Expect = 5e-81,   Method: Composition-based stats.
 Identities = 105/255 (41%), Positives = 151/255 (59%), Gaps = 8/255 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR S LA+ QA  VKD+L +   G+  E+    ++GD+ LD+PL  +GG G+FV +
Sbjct: 3   IRIGTRSSKLAMIQAMMVKDRLDSL--GIETEVKGFTSKGDINLDSPLYSIGGTGVFVDD 60

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L   +L+N  DIAVHS KD+P      L +  + +R+DPRD  +S +  SL+ L A S++
Sbjct: 61  LNRMILKNEIDIAVHSAKDIPSFIDDSLEISAVLKRDDPRDVLISQH--SLNDLEASSVI 118

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSSLRR  +L   R D++I+ LRGN+ TRL KLDNG+YD II+A A   R+ +  R   
Sbjct: 119 GTSSLRRIKELKTLRNDILIKDLRGNIDTRLKKLDNGDYDGIIMAKAAYDRMRINRR-HF 177

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L  +  +PA  QG + I     DS   ++L  +N  ET   + AER + + L  GC  P
Sbjct: 178 ILNYDDFVPAPNQGIIAI-ISKKDSEINDVLKKINDDETYNDMKAERLILSGLNLGCSKP 236

Query: 246 IGSYAELIDGEIWLR 260
           +G YA      I++R
Sbjct: 237 VGIYAH--KNRIFMR 249


>UniRef50_A8PWJ5 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS
           7966 RepID=A8PWJ5_MALGO
          Length = 530

 Score =  303 bits (776), Expect = 7e-81,   Method: Composition-based stats.
 Identities = 132/394 (33%), Positives = 188/394 (47%), Gaps = 92/394 (23%)

Query: 5   VLRIATRQSPLALWQAHYV------------------------------KDKLMASHPG- 33
            L +++R+S LA+ QA  V                              +  L    P  
Sbjct: 89  TLVLSSRKSELAVRQATQVQMLLDTRYGRASPVFAPGADQWPSTEVANIRAFLRTFSPDQ 148

Query: 34  -----LVVELVPMVTRGDVILDTPLAKVGGKG--LFVKELEVALLENRADIAVHSMKDVP 86
                +   +  M T GD  L +PL  +GG+G  ++ KELEVAL+    D  VHS+KDVP
Sbjct: 149 KDVRPVDFPVRTMATLGDQNLKSPLYVIGGEGRAIWTKELEVALMAGGVDAIVHSLKDVP 208

Query: 87  VEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALPAGSIVGTSSLRRQCQLAERRPDL 143
              P G+ L  I EREDPRDA V      Y SL  +P GS++GTSS+RR   L    P L
Sbjct: 209 TTMPDGVELAAILEREDPRDALVVKENLPYKSLQEMPQGSVIGTSSVRRVSLLRRAYPHL 268

Query: 144 IIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAV 201
           +   +RGN+ TRL+KLD  +G Y A++LA AGLKR+ LE RI A +   + L AVGQG++
Sbjct: 269 MFSDVRGNINTRLAKLDAADGPYTALVLAAAGLKRMDLEHRITAYVSEPVMLHAVGQGSL 328

Query: 202 GIECR-------LDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID 254
            IE R         D R R ++ ++++     R  AERA+  R+EGGC +P+G      D
Sbjct: 329 AIEVRTPRGESAERDERIRRMIRSISNWRATWRCVAERALMHRMEGGCSIPLGVSTRFED 388

Query: 255 GE--------------------------------------IWLRALVGAPDGSQIIRGER 276
                                                   + + A++ + DG+++ +   
Sbjct: 389 HADIEGLLNERNETPSEMASAGISRPDIRIAHEPPPQGSFLTMAAVIVSLDGTRMCKHSH 448

Query: 277 RG---APQDAEQMGISLAEELL-NNGAREILAEV 306
                + +DAEQ+GI +AEEL  +  AR ILAEV
Sbjct: 449 TQLCRSEKDAEQLGILVAEELEHHQNARAILAEV 482


>UniRef50_B2ULP1 Porphobilinogen deaminase n=1 Tax=Akkermansia muciniphila ATCC
           BAA-835 RepID=B2ULP1_AKKM8
          Length = 325

 Score =  302 bits (774), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 121/317 (38%), Positives = 157/317 (49%), Gaps = 21/317 (6%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG---- 57
             N L I TR S LAL QA  V+  L   +P L V    + T GD   D PLA V     
Sbjct: 3   SKNTLIIGTRGSALALAQADMVRAALSLRYPELDVRCEIIHTIGDRRTDVPLADVARVSG 62

Query: 58  --GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS 115
              KG+F+KELE AL + R D+AVHS+KDVP E   G  L  +  R    D  ++   D 
Sbjct: 63  MVDKGIFIKELETALRDGRIDVAVHSLKDVPSELAAGFTLAAVLPRAAVEDVLITKEPDW 122

Query: 116 LDALPAGSIVGTSSLRRQCQLA-ERRPDLIIRSLRGNVGTRLSKL-DNGEYDAIILAVAG 173
             +      + T S+RR+          L   +LRGNV TRL KL ++  +DA+ILA AG
Sbjct: 123 NGS----GTLATGSVRRRLMARTYWGSGLRFENLRGNVPTRLGKLVEHPGWDAVILARAG 178

Query: 174 LKRLGLESRIR---------AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224
           L+RLGL +              LP E+ +PAVGQG VG+ECR  D  T E+L  +N  E+
Sbjct: 179 LERLGLYAPETLVEGRKLYMRPLPVEVFIPAVGQGIVGMECRSSDRETAEMLEGINDPES 238

Query: 225 ALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAE 284
                AERA   RL   C  P+G YA     E+ LRA    P   +      RG  +  E
Sbjct: 239 FACALAERAFLVRLGANCSTPVGVYAHPDGEELVLRAAYYVPGREEPFAVVIRGDRKAPE 298

Query: 285 QMGISLAEELLNNGARE 301
            +G+   EEL  +G R+
Sbjct: 299 ALGLRAFEELGLSGWRK 315


>UniRef50_Q5KKQ0 Hydroxymethylbilane synthase, putative n=2 Tax=Filobasidiella
           neoformans RepID=Q5KKQ0_CRYNE
          Length = 481

 Score =  302 bits (773), Expect = 2e-80,   Method: Composition-based stats.
 Identities = 123/413 (29%), Positives = 169/413 (40%), Gaps = 107/413 (25%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPG-------------------------LVVE 37
            N   + TR+S LAL Q  +V D L   H G                             
Sbjct: 30  TNTFILGTRKSNLALVQTGHVADDLRRLHSGAGSKFGETREEGDDAEQGDVPFVHPYTFS 89

Query: 38  LVPMVTRGDVILDTPLAKV-------GGKGLFVKELEVALLENRADIAVHSMKDVPVEFP 90
           +  M T GD    TPL  +         K L+  ELE  L+    D+ VHS+KDVP    
Sbjct: 90  IESMTTVGDRNQTTPLHLLSPYSSTQPAKSLWTDELEARLINGHFDMLVHSLKDVPTVLK 149

Query: 91  QGLGLVTICEREDPRDAFVSNN---YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRS 147
            G  +  + +R DPRDA V      Y  L+ LP G++VGT S+RR  QL    P+L+   
Sbjct: 150 DGCEIGCMAKRHDPRDALVVKQGLPYKRLEDLPDGAVVGTGSVRRVAQLKRAFPNLVFED 209

Query: 148 LRGNVGTRLSKLDNGE--YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIEC 205
           +RGN+ TR +KLDN +  + A+ILA++GL+RLG+  R  + L     + AVGQGA+ IE 
Sbjct: 210 MRGNLNTRFNKLDNPQSPFSALILAMSGLERLGMAHRATSPLSSPTLMHAVGQGALAIEI 269

Query: 206 RLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP--------------IGSYAE 251
           R  D R R  L  L H +T     AER     LEGGC VP              + ++ E
Sbjct: 270 RSTDPRVRNCLRGLGHWQTEWSCGAERGCLRVLEGGCSVPVGVESELVELDEDEVAAHPE 329

Query: 252 LIDG----------------------------------------------------EIWL 259
           L++G                                                    ++ L
Sbjct: 330 LLEGVEDPFKGQEEIPLEGDSPMLWFSGLVDTTSAPTPSTPTFSSHSLPPLRTRLAKLTL 389

Query: 260 RALVGAPDGSQIIRGE----RRGAPQDAEQMGISLAEELLNNGAREILAEVYN 308
            + V + DGS+ +          + + AEQ G   A  L   GA EIL E+  
Sbjct: 390 HSCVTSTDGSKHVLFTPPPVLVRSYRQAEQFGEECARRLRGMGAGEILDEINK 442


>UniRef50_C7DH16 Porphobilinogen deaminase n=1 Tax=Candidatus Micrarchaeum
           acidiphilum ARMAN-2 RepID=C7DH16_9EURY
          Length = 301

 Score =  301 bits (772), Expect = 2e-80,   Method: Composition-based stats.
 Identities = 107/306 (34%), Positives = 174/306 (56%), Gaps = 7/306 (2%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M ++ + I TR S LA+ QA  V++KL A  P +   +V + T  + + D   A+   K 
Sbjct: 1   MSESEITIGTRGSELAVAQAEIVRNKLAAIEPRISFRIVKIKTLNEKV-DRSKART-EKD 58

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           ++ KE++ A+LE R DIAVHS+KD+     + + +  + +R+DPRD F+ N     + L 
Sbjct: 59  IYTKEIDEAILERRIDIAVHSLKDLKFNMDENMQIGAVPDRDDPRDVFIGNTETEFEHLG 118

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
             ++VGTSS+RR+ QL    P  +I  L GN+ TRLSKL++GE+  I++A AG+KRLG  
Sbjct: 119 TDALVGTSSIRRRVQLTRINPKPMISDLHGNIDTRLSKLNSGEFSGIVIAAAGVKRLGKA 178

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            R++     ++ +PA+GQGA+ +    D+S   ELL  +++ +  + V  E         
Sbjct: 179 VRMQYFDERDV-VPAIGQGAIAVTVHKDNSAAAELLKRIDNMKARVEVGEEIEFGKAFGT 237

Query: 241 GCQVPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
           GC +PIG+ A++++ G+I +   V    G  +++GE    P  A   G SLAE L+  GA
Sbjct: 238 GCNLPIGANAKMLESGKIGIVGFVSDLAGKTLVKGETETGPGHA---GKSLAELLIKKGA 294

Query: 300 REILAE 305
             ++  
Sbjct: 295 GNLIER 300


>UniRef50_B3LB83 Porphobilinogen deaminase, putative n=1 Tax=Plasmodium knowlesi
           strain H RepID=B3LB83_PLAKH
          Length = 449

 Score =  301 bits (772), Expect = 2e-80,   Method: Composition-based stats.
 Identities = 101/367 (27%), Positives = 166/367 (45%), Gaps = 73/367 (19%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHP----GLVVELVPMVTRGDVILDTPLAKVGGK 59
             + I TR SPLA+ Q+  V+ KL A        + + L  + T GD ILD  +   GGK
Sbjct: 65  KEIIIGTRDSPLAIKQSEKVRTKLEAYFKKVNKNVKITLKSIKTMGDNILDQKVDLFGGK 124

Query: 60  GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119
           G+F KEL+  L++ +  I VHS+KDVP+E P+ + L    +R+   DAF+S  Y +L+ +
Sbjct: 125 GIFTKELDEELIKGKVHICVHSLKDVPMELPEQVQLSCFLKRDTINDAFLSVKYGTLEDM 184

Query: 120 ---------------PAGS------------------------IVGTSSLRRQCQLAERR 140
                          P G                          +GTSSLRR  Q+  + 
Sbjct: 185 NKMKMANKMEEGSYQPKGMSQRVINQNVKRDNYEGDHYDNFIPTIGTSSLRRSSQIKYKY 244

Query: 141 PDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAA-------------- 186
            ++ ++++RGN+ TR++KL NG+YDAII+A  GL+RL  +  IR                
Sbjct: 245 KNVAVKNMRGNINTRIAKLCNGQYDAIIIAKCGLERLTTKKGIRNIIGGKNKVTPKNFLI 304

Query: 187 ----------------LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTA 230
                           +      PA+ QG + +     D    ++L  +N  +  +    
Sbjct: 305 NYNNTEINLTSLHIQQINKRTIYPALCQGIIAVSSHKSDKYISDVLKNINDEKAQIMANI 364

Query: 231 ERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISL 290
           ER+   ++EG C +PIG YA++++GEI   A++    G +       G  +   ++ +  
Sbjct: 365 ERSFLYQIEGNCMMPIGGYAKIVNGEIVFNAVINDIHGREKYHVREVGKVESYNEIAVMA 424

Query: 291 AEELLNN 297
           A ++   
Sbjct: 425 ATKMKEK 431


>UniRef50_D1B7N1 Porphobilinogen deaminase n=1 Tax=Thermanaerovibrio acidaminovorans
           DSM 6589 RepID=D1B7N1_THEAS
          Length = 307

 Score =  299 bits (767), Expect = 8e-80,   Method: Composition-based stats.
 Identities = 114/298 (38%), Positives = 159/298 (53%), Gaps = 12/298 (4%)

Query: 10  TRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVA 69
           TR SPLA+ QA   KD++ +   G  V L+ + T GD      LA  GG G FVK LE  
Sbjct: 8   TRSSPLAMAQARMWKDRIESL--GHSVRLLDVSTHGDRDRRRHLACFGGFGAFVKALEDR 65

Query: 70  LLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSS 129
           LL  +   AVHS+KDVP   P GL +  + ER    D  V+    SL+ LP+G+++GTSS
Sbjct: 66  LLSGQGHGAVHSLKDVPSVQPDGLVIAGVLERGPRGDVLVTREGLSLEELPSGAVIGTSS 125

Query: 130 LRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPP 189
           +RR  Q+   R DL +   RGNV +RL KL+ G +  I+LA AGL+RLG    IRA +  
Sbjct: 126 IRRAAQVRMLRGDLNVECCRGNVHSRLRKLEQGLFHGIVLARAGLERLG----IRAPMAE 181

Query: 190 EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSY 249
              + + GQGAV +E R   S    L A L H  T L V AER+       GC  P+ + 
Sbjct: 182 LPFITSPGQGAVALEAREG-SELHLLGARLTHRSTWLEVLAERSFLKAFGMGCSAPVAAS 240

Query: 250 AELIDGEIWLRALVGAPDGSQIIRGERRGAP---QDAEQMGISLAEELLNNGAREILA 304
           A +    + L+  V +P+G+     E    P   +DA  +G +   E+  +G+ E+L+
Sbjct: 241 AVMDRDTLTLKVQVLSPNGTSAAEAEVSCVPWGEEDAYALGEAAFREI--SGSPEVLS 296


>UniRef50_A6LKX0 Porphobilinogen deaminase n=1 Tax=Thermosipho melanesiensis BI429
           RepID=A6LKX0_THEM4
          Length = 279

 Score =  299 bits (766), Expect = 9e-80,   Method: Composition-based stats.
 Identities = 94/246 (38%), Positives = 141/246 (57%), Gaps = 6/246 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +R+ TR+S LAL Q   V +KL    P +  E+ P+VT+GD  L TP+ K+GGKG+FV +
Sbjct: 3   IRVGTRKSKLALIQTQLVVNKLKELLPNIDFEITPVVTKGDR-LKTPIDKIGGKGVFVSD 61

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E  +L+++ DIA+HSMKD+P + P  L L ++ +RE P D F+     +   L  G+ +
Sbjct: 62  IEKLILDDKLDIAIHSMKDLPSKIPDKLFLTSVLKRECPNDVFIGKE--NFFNLKKGAKI 119

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS RR  Q+   RPD+ I  +RGNV TR+ K+  GE D I++A AG+ RLGL+ +I  
Sbjct: 120 GTSSKRRALQINMLRPDIEIVPIRGNVDTRIKKI--GELDGIVIAAAGVIRLGLKDKITN 177

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSR-TRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
               E  +PA  QG + +E      +   E+   +   +T +    ER + + L   C  
Sbjct: 178 LFEFEKIVPAPCQGILALEFSEKFLKPFEEIKDVIVDPKTEVETQIERKILSLLNFDCNT 237

Query: 245 PIGSYA 250
           P G Y 
Sbjct: 238 PFGFYC 243


>UniRef50_A2SQU4 Uroporphyrin-III C-methyltransferase n=11 Tax=Euryarchaeota
           RepID=A2SQU4_METLZ
          Length = 542

 Score =  298 bits (765), Expect = 1e-79,   Method: Composition-based stats.
 Identities = 119/308 (38%), Positives = 165/308 (53%), Gaps = 22/308 (7%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           + +RI TR S LAL Q   V   L  +  G+  E V + T GD + D  L ++GG G+FV
Sbjct: 2   SKIRIGTRGSKLALAQTKKVIGLLAEN--GIDAEYVIIKTTGDKVTDRGLHQIGGFGMFV 59

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           +EL+ A+L    D AVHSMKD+P E P+GL  V + +R+ P D  V N    ++ L    
Sbjct: 60  RELDNAILRGEIDCAVHSMKDIPAERPKGLLTVAVLKRDPPYDFLVMNG--KVEDL---M 114

Query: 124 IVGTSSLRRQCQLAERR---PDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
           ++GTSSLRR+ QL       P + +  LRGN+ TRL KLD+G YD I++A AGL RL  +
Sbjct: 115 VIGTSSLRRKAQLLRYFHNCPAVRVEMLRGNLDTRLGKLDDGLYDGIMVAEAGLMRLDYK 174

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            R    L P++ +PA  QG + I  R D    R   A LN  ++AL    ER +  ++ G
Sbjct: 175 -RNGVRLSPDMFVPAANQGTIAIVSR-DTPELRAAFAPLNDPQSALDCAIERIVMEQVGG 232

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-GAPQDAEQMGISLAEELLNNGA 299
           GC  P+G + E       L A V + DG++  R     G  + A   GI     L N GA
Sbjct: 233 GCFTPMGIFCENQ----HLTAEVLSLDGTRAERITAEIGDLEGARVAGI----RLKNVGA 284

Query: 300 REILAEVY 307
            E++AE  
Sbjct: 285 -ELIAEAK 291


>UniRef50_C5EV71 Pyruvate ferredoxin/flavodoxin oxidoreductase n=3 Tax=Clostridiales
           RepID=C5EV71_9FIRM
          Length = 301

 Score =  298 bits (764), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 119/305 (39%), Positives = 165/305 (54%), Gaps = 15/305 (4%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           + N++RI TR+S LAL Q H + D L  + P + VELV   T GD ILD PL + GGKG+
Sbjct: 1   MSNIIRIGTRKSALALIQTHLIADGLKRAWPDIEVELVTKETLGDKILDKPLQEFGGKGV 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FV E E A+ E   D+AVHS KD+P+E  +GL +  +  R DPRD  V+      D    
Sbjct: 61  FVSEFEQAMKEGAIDLAVHSAKDLPMELGEGLVIAAVSGRGDPRDVLVTMKGSPKDR--E 118

Query: 122 GSIVGTSSLRRQCQLAERR-------PDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174
             ++GTSS RRQ +  E R         L   +LRGNV TRL KL+ G YD IILA AGL
Sbjct: 119 HIVIGTSSPRRQLEAVEYRGQLWPGAASLTCATLRGNVHTRLRKLEEGLYDGIILAAAGL 178

Query: 175 KRLGLESRIRA---ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231
           +RL L          L P + +PA GQG + +E R   S    L  A++  E  L +T E
Sbjct: 179 ERLDLLGNPSYDFKYLDPTVFIPAGGQGIMAVEAREG-SDAARLCQAIDSREGRLCLTLE 237

Query: 232 RAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDG-SQIIRGERRGAPQDAEQMGISL 290
           R +   L+ GC  PIG Y+ ++DG++ +   +  PD  ++ I  E     ++ E + +  
Sbjct: 238 RMVLKLLDAGCHEPIGIYSNIMDGKMEVWG-ISRPDRVTRRISLEGAVTEKELEALALQA 296

Query: 291 AEELL 295
              L+
Sbjct: 297 GRGLM 301


>UniRef50_A3VPD5 Porphobilinogen deaminase n=1 Tax=Parvularcula bermudensis HTCC2503
           RepID=A3VPD5_9PROT
          Length = 324

 Score =  298 bits (763), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 135/286 (47%), Positives = 178/286 (62%), Gaps = 6/286 (2%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMAS------HPGLVVELVPMVTRGDVILDTPLA 54
           M    LRIA+R+SPLA+ QA +V+D+L  +                 VT GD +L+  LA
Sbjct: 1   MSFKPLRIASRRSPLAVAQALWVRDRLAEALGIDEVDRDAAFPHETFVTTGDRMLNPTLA 60

Query: 55  KVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD 114
            +GGKGLF KE+E+ALL+ +ADIAVHSMKD+P + P GL L  +  REDPRDAFV+ +  
Sbjct: 61  DIGGKGLFTKEIEIALLDGQADIAVHSMKDMPAQMPPGLVLAAVPVREDPRDAFVTLDGR 120

Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174
            LD +PAG+ +GTSS RR+ QLA  RPDL +  +RGNVGTRL KL  GE +   LA AGL
Sbjct: 121 PLDQMPAGARIGTSSTRRRAQLARLRPDLALVPMRGNVGTRLQKLAAGEAEGTFLAEAGL 180

Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234
           +RLG+    R AL P   LPA+GQGA+ ++ R  D  T    A +N+  TAL   AERA+
Sbjct: 181 RRLGMTDVKREALSPARMLPALGQGALCVQARSGDHETLSACAHINNRPTALAAAAERAL 240

Query: 235 NTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAP 280
            + L+G C+ PIG  A      + L   +  PDG +++RGER  A 
Sbjct: 241 ISGLDGSCKTPIGGLARQTGDSLILEGQILTPDGRRVLRGERTVAI 286


>UniRef50_Q1AUK3 Porphobilinogen deaminase n=1 Tax=Rubrobacter xylanophilus DSM 9941
           RepID=HEM3_RUBXD
          Length = 305

 Score =  297 bits (761), Expect = 4e-79,   Method: Composition-based stats.
 Identities = 133/302 (44%), Positives = 174/302 (57%), Gaps = 5/302 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   L + TR SPLAL QA      L A+  G  VEL  + T  D   D PL+ +  + +
Sbjct: 1   MAGRLVLGTRGSPLALAQAEACAAGLRAA--GFAVELRRIRTTSDRRPDDPLSVIDQRDV 58

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F ++L+ ALL    D+AVHSMKDVP E P+G+ L  +  R DP DA VS     +D LP 
Sbjct: 59  FTRQLDEALLAGEVDLAVHSMKDVPTEVPEGIVLAAVAGRADPSDALVSEGGWGVDGLPE 118

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ V TSSLRR+ QL  RRPDL +  +RGNV TR+ K+  G  +A++LA AGL RLGLE 
Sbjct: 119 GARVATSSLRRRAQLLHRRPDLRVVEIRGNVDTRIRKMRAGAAEAVVLARAGLVRLGLEV 178

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
              A +P ++ LPAVGQGA+ +  R  D R  E+  ALN       V AERA+   LEGG
Sbjct: 179 P-HAVIPHDVLLPAVGQGALAVAVRRGDPRLEEIRRALNDPAAEREVAAERALLRALEGG 237

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           C+VP+G+ A      + LR +V +PDG+ +  GE RG   +       LA  LL  GA  
Sbjct: 238 CRVPVGARAVAGGRGVLLRGVVVSPDGAALCGGEERGEEPEEVG--RRLAARLLERGAAG 295

Query: 302 IL 303
           IL
Sbjct: 296 IL 297


>UniRef50_C3MZR8 Probable porphobilinogen deaminase n=11 Tax=Sulfolobus
           RepID=HEM3_SULIA
          Length = 293

 Score =  297 bits (761), Expect = 4e-79,   Method: Composition-based stats.
 Identities = 97/292 (33%), Positives = 148/292 (50%), Gaps = 9/292 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RIA R S L+  Q   + +KL     G+  E++ + T+ D+    PL+K+G KG+F KE
Sbjct: 3   IRIAARGSKLSRIQVDMLGEKLKKI--GIEYEIIDIKTKADLFSTEPLSKLG-KGVFEKE 59

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +  A+LE +ADIAVHSMKD+  E    L +  + ER+ P D  ++    +LD L +   +
Sbjct: 60  VNEAVLEGKADIAVHSMKDILSEINPSLEIFAVLERDPPYDILIAEK--NLDKLDSNITI 117

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS+RR+  L   +P++  + +RGNV TR+ K  + EY  +ILA A LKRL +      
Sbjct: 118 GTSSIRRKNFLKYIKPEINTKDIRGNVDTRIRKYLSKEYQGLILAEASLKRLNMTMNYHR 177

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
               +   P   QG +    R  D + +E+   +NH +T     AERA+ + + GGC  P
Sbjct: 178 LNVYD-FTPEANQGIIVALGRKKDEKIKEIFKEINHKDTLDEALAERAVISLVGGGCHSP 236

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           IG   +    E +   +    DG + I       P D   +G  L   L   
Sbjct: 237 IGVLFKKEGKEFY--GIASYSDGKKKITVSIS-KPGDPYTIGSELGLLLKKE 285


>UniRef50_C7M2H5 Porphobilinogen deaminase n=1 Tax=Acidimicrobium ferrooxidans DSM
           10331 RepID=C7M2H5_ACIFD
          Length = 291

 Score =  296 bits (758), Expect = 8e-79,   Method: Composition-based stats.
 Identities = 123/299 (41%), Positives = 171/299 (57%), Gaps = 14/299 (4%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            +RIATR+S LA WQA  V ++L         ELV + T GD    + LA++GG+G+FVK
Sbjct: 3   PVRIATRRSALARWQASLVGERLGRY------ELVEVHTAGDRDQASSLAEIGGQGVFVK 56

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           E++ A++   ADIAVHS KD+P      L L  + ER D RDA V      L+ L  G+ 
Sbjct: 57  EVQAAVVRGEADIAVHSAKDLPTAAGP-LLLAAVLERADARDAIV---GARLEELAIGAR 112

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGTS+ RR  QL   RPDL + S+RGN+ TRL ++  GE DAI++AVA L+RLGLE    
Sbjct: 113 VGTSAPRRAAQLRLLRPDLEVVSIRGNIATRLGRV--GELDAIVMAVAALERLGLEEPPW 170

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             LP E+  P  GQGA+ +EC  D     E L +L+   +   + AERA+      GC +
Sbjct: 171 WPLPEEVLCPQAGQGAIAVECAPDADGLIERLRSLDDDRSRREIEAERAVLAAFGTGCAL 230

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           P+G+ A      + LRA+   PDG++ +  ER G   D   +G ++AE L   GA  ++
Sbjct: 231 PLGARAHADGSSLRLRAVAVDPDGTRQLEVEREGV--DPATLGATVAEVLRRLGADALV 287


>UniRef50_C7R376 Porphobilinogen deaminase n=1 Tax=Jonesia denitrificans DSM 20603
           RepID=C7R376_JONDD
          Length = 344

 Score =  295 bits (756), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 126/344 (36%), Positives = 172/344 (50%), Gaps = 47/344 (13%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LR+ TR S LA  Q+      L+A   G+ V+L  + T GD +L   LA +GG G+FV  
Sbjct: 4   LRLGTRASALATAQSRATA-ALIAQATGVTVDLTHIRTDGD-VLTGSLATMGGAGVFVTA 61

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +  ALL    DIAVHS+KD+P    +G  ++ + ERE+P+DA  S + +SL  LP G++V
Sbjct: 62  IRQALLAGDIDIAVHSLKDLPTTPHEGTTII-VPERENPQDALCSRHGESLAHLPHGALV 120

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD---------NGEYDAIILAVAGLKR 176
           GT S RR  QL   RPDL I  +RGNV TRL+++            + DA++LA AGL+R
Sbjct: 121 GTGSPRRAAQLLVARPDLRIVDIRGNVDTRLARVGLSTADKPHIRNDLDAVVLAAAGLRR 180

Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSR----TRELLAALNHHETALRVTAER 232
           LG    I   LPP   LPA GQGA+ IE R D +         +  L+H  TA  V AER
Sbjct: 181 LGRAHVISELLPPTSMLPAPGQGALAIEVRHDMADHHPSILAGIRTLHHQPTAYAVAAER 240

Query: 233 AMNTRLEGGCQVPIGSYAEL-----------IDGEIWLRALVGAPDGSQII--------- 272
           A+   LE GC  P+G+ A +           +D  +   A    P  +  I         
Sbjct: 241 AVLRHLEAGCAAPVGALATMHNTTLTLTATALDPRLTPTAHTPTPSTTTDINAAPTPMTA 300

Query: 273 -----------RGERRGAPQDAEQMGISLAEELLNNGAREILAE 305
                            +  DA + GI+LA  LL +GA E L +
Sbjct: 301 PADARPPIRLTHTHTVTSENDATEAGITLATTLLTHGAAEFLRD 344


>UniRef50_Q0ATQ1 Porphobilinogen deaminase n=3 Tax=Alphaproteobacteria
           RepID=Q0ATQ1_MARMM
          Length = 321

 Score =  294 bits (754), Expect = 2e-78,   Method: Composition-based stats.
 Identities = 129/305 (42%), Positives = 165/305 (54%), Gaps = 14/305 (4%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMA------SHPGLVVELVPMVTRGDVILDTPLAKV 56
              L IATR+SPLAL QA  V+ KL A              ++ +V+ GD I D  L + 
Sbjct: 5   SRPLAIATRRSPLALVQARDVQAKLAAQCGLSGEDAERCFPILGLVSTGDRIQDRTLIEA 64

Query: 57  GGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS- 115
           GGKGLF KE++ A L+ RA  AVHSMKDVP   P G+ L  + EREDPRD  ++ + ++ 
Sbjct: 65  GGKGLFTKEIDEAQLDGRAAFAVHSMKDVPTVLPDGIVLGALLEREDPRDMLIARDGETR 124

Query: 116 LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLK 175
           L  LP G  +GT+SLRRQ QL  +RPDL +  LRGNV TRL KL +G   A  LA AGL 
Sbjct: 125 LADLPEGVTIGTASLRRQAQLLHKRPDLHVVPLRGNVDTRLGKLADGGIHATFLARAGLN 184

Query: 176 RLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235
           RLG    +R  L  +  LPA  QGAVG+  R  D      +A L+H +T L V AERA  
Sbjct: 185 RLGRAEALRDPLEADEMLPAAAQGAVGVAIRDGDEEAASYVAGLHHRDTELAVLAERAFL 244

Query: 236 TRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-----GAPQDAEQMGISL 290
             L+G C+ PI ++   +   +     V  PDG Q  R + R       P  A Q G  L
Sbjct: 245 FELDGSCRTPIAAHVNKV--SMDFIGEVLTPDGQQSWRRQIRFDMTHATPDSARQAGQDL 302

Query: 291 AEELL 295
              + 
Sbjct: 303 GRAVR 307


>UniRef50_A4YD92 Probable porphobilinogen deaminase n=1 Tax=Metallosphaera sedula
           DSM 5348 RepID=HEM3_METS5
          Length = 290

 Score =  294 bits (754), Expect = 3e-78,   Method: Composition-based stats.
 Identities = 110/296 (37%), Positives = 153/296 (51%), Gaps = 14/296 (4%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RIA R S L+L Q   V   L A   G   E + + T+ D+  + PL ++G KG+F KE
Sbjct: 3   IRIAARGSKLSLKQVEIVTTYLQAK--GYETEFIEIKTKADLFGNKPLHEIG-KGVFEKE 59

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +  A+L+ RADIAVHSMKD+  E P GL L+   +RE+P D  VS    +L+ LP  S +
Sbjct: 60  VNEAVLQGRADIAVHSMKDMSSELPPGLELLATPKRENPVDVLVSE--LNLEELPEKSRI 117

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GT SLRR   L   RPDL++ ++RGNV TRL K  + EYD IILA AGL+RLG+E + R 
Sbjct: 118 GTGSLRRANFLKVVRPDLVVENIRGNVDTRLRKYRDHEYDGIILAEAGLRRLGVEVK-RF 176

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L  E   P   QG + +       +   L   LN   T     AE+     + GGC  P
Sbjct: 177 PLDVESFTPEPNQGIIAVV---GSPKFLGLFQELNDTGTMKEALAEKETVKVVGGGCHSP 233

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIR---GERRGAPQDAEQMGISLAEELLNNG 298
           +G    L D    L  +    +G + +      R        Q+G +L + + + G
Sbjct: 234 LGVLFRLEDD--VLHGIASYSNGVKRVTVKLSTRESPQIAGNQLGKALVKAMKDEG 287


>UniRef50_C4JRY9 Porphobilinogen deaminase n=1 Tax=Uncinocarpus reesii 1704
           RepID=C4JRY9_UNCRE
          Length = 287

 Score =  294 bits (753), Expect = 3e-78,   Method: Composition-based stats.
 Identities = 107/318 (33%), Positives = 155/318 (48%), Gaps = 58/318 (18%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
               I TR+SPLAL Q   V+  L  ++P                               
Sbjct: 7   KTYTIGTRKSPLALVQTDLVRRALQTAYPN------------------------------ 36

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD---SLDALP 120
                       D+ VH    VP + P    L  +  RE+PRD  V        +L  LP
Sbjct: 37  -----------CDLKVHG--HVPTQIPDACVLGAMMPRENPRDVLVIKKGLPWMTLAELP 83

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLKRLG 178
           AGS+VGTSS+RR  QLA   P L+++ +RGN+ TRL+KLD  +G +  +I+A AGL R G
Sbjct: 84  AGSVVGTSSVRRTAQLARHYPHLVVQDIRGNIDTRLAKLDAEDGPFTCLIMAAAGLLRTG 143

Query: 179 LESRIRAALPPE--ISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236
            E+R+   L  +    L AVGQGA+GIE R DD   ++++  +    T     AER +  
Sbjct: 144 HENRVTQYLDSKNGKMLHAVGQGALGIEVRTDDEVMKDMVNKIGDMPTTYACMAERNLLR 203

Query: 237 RLEGGCQVPIGSYAELIDGE-----IWLRALVGAPDGSQIIRGERRG---APQDAEQMGI 288
            +EGGC  P+G   E I  +     + LRA+V + DG + +  E+ G   + ++AE  G 
Sbjct: 204 TVEGGCSAPLGVETEWIQDDNGKSLLRLRAIVVSVDGKEAVELEKDGDVESIEEAEAFGK 263

Query: 289 SLAEELLNNGAREILAEV 306
            +A EL++ GA +IL E+
Sbjct: 264 QVALELIDKGAGKILEEI 281


>UniRef50_D1JID7 Porphobilinogen deaminase n=1 Tax=uncultured archaeon
           RepID=D1JID7_9ARCH
          Length = 290

 Score =  291 bits (747), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 98/295 (33%), Positives = 154/295 (52%), Gaps = 11/295 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           + + TR S LAL Q   V ++L     G+  E+  + + GDV+ D  L ++   G+FVK+
Sbjct: 1   MIVGTRGSNLALVQTKKVCERLSEL--GVECEIKTVQSLGDVMTDRGLYEMPTIGVFVKK 58

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L++ LL+ + DIAVHSMKD+P E  + L    +  R+ P DA VS     LD +P G+++
Sbjct: 59  LDMMLLDAKIDIAVHSMKDMPSEREEELDTSAVLPRDSPYDALVSRY--RLDDMPEGAVI 116

Query: 126 GTSSLRRQCQLAE----RRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           GTSS+RR+ Q       R   + I+ +RGNV TR++K   GEYD++ILA AG +RL L+ 
Sbjct: 117 GTSSVRRRYQFLNYVGERGVKVTIKDIRGNVDTRIAKFRRGEYDSVILAEAGFERLKLDI 176

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
                L  +  +P+  QG + +  R       E+L  ++  ET +    E  +   + GG
Sbjct: 177 E-YERLDRDPFVPSPRQGIIAVVARRGSKE-SEILKQIDDSETRIEAEVEEEVLKVIGGG 234

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
           C +P+G +A    G + L   V A D    +     G     E+    LA++  +
Sbjct: 235 CSLPVGVHATAKGGSVELAVYVAASDVRYKLEKVVLGKDYYMEET-RELAQKFKS 288


>UniRef50_A9HK97 Porphobilinogen deaminase n=12 Tax=Acetobacteraceae
           RepID=A9HK97_GLUDA
          Length = 367

 Score =  291 bits (745), Expect = 3e-77,   Method: Composition-based stats.
 Identities = 134/321 (41%), Positives = 171/321 (53%), Gaps = 21/321 (6%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLV----VELVPMVTRGDVILDTPLAKVGGKG 60
            LR+ TR SPLAL Q       L    P L      +   + T GD + +  LA++GGKG
Sbjct: 46  PLRVGTRASPLALVQTRAFLTMLTRFCPVLRDMGAFQEHQINTTGDQVQNRRLAEIGGKG 105

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY------- 113
           LF KE+  AL + R D AVHS+KD+    P GL L     RED RDA +           
Sbjct: 106 LFAKEIHDALSDGRIDFAVHSLKDLETTLPPGLVLACTLRREDARDALILGPGAGGRHDA 165

Query: 114 ----DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIIL 169
               D   ALP  ++VG +S+RRQ Q+   RPDL    LRGNV TRL KL   + DA +L
Sbjct: 166 ADAADPYAALPRNALVGCASVRRQAQMLHVRPDLRFGLLRGNVQTRLDKLAARQCDATLL 225

Query: 170 AVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVT 229
           A+AGL+RLG+E R    L PEI +PA GQG VG+  R  D   RELLAA+  +E     T
Sbjct: 226 ALAGLRRLGMEDRADIVLDPEIMVPAAGQGIVGVTVRESDVELRELLAAIEDYEARAVAT 285

Query: 230 AERAMNTRLEGGCQVPIGSYAELIDG------EIWLRALVGAPDGSQIIRGERRGAPQDA 283
           AERA+   L+G C+ PIG YA L+ G       + L  LV   DGS ++R    G   DA
Sbjct: 286 AERALLAELDGSCRTPIGGYARLVPGLAGAEASLRLTGLVAREDGSFLLRRTVTGLRADA 345

Query: 284 EQMGISLAEELLNNGAREILA 304
           E+MG  L   L  +   ++ A
Sbjct: 346 EEMGRELGRSLRMDSPSDVFA 366


>UniRef50_B5GJG2 Porphobilinogen deaminase n=3 Tax=Streptomyces RepID=B5GJG2_9ACTO
          Length = 335

 Score =  289 bits (741), Expect = 8e-77,   Method: Composition-based stats.
 Identities = 113/308 (36%), Positives = 153/308 (49%), Gaps = 12/308 (3%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTP----LAKVGGK 59
             + + +R S LA  Q   + ++     PG+      +   GD    TP    + +  G 
Sbjct: 31  RTVTVGSRGSALARAQVREMVERWEREVPGVRFVRRVITEAGDADRSTPTVAGVTRRAGV 90

Query: 60  GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTIC-EREDPRDAFVSNNYDSLDA 118
             F    E AL+    D+ VH +KD+P     G  L+     RED RDA       +L  
Sbjct: 91  SAFSSRQEAALVRREVDVVVHCLKDLPTTPAPGTALLRTPGPREDARDALC---GATLAG 147

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178
           LP G+ VGT S RR  QL   RPDL +  +RGNV  RL++L     DA++LA AGL RLG
Sbjct: 148 LPRGARVGTGSTRRVAQLLALRPDLEVIPVRGNVPARLARLRT--LDAVVLAAAGLHRLG 205

Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
           L   I   L PE   PA GQGA+ I+ R   S    LLAA     T   V AER +   L
Sbjct: 206 LTEEITEYLDPEAYPPAPGQGALAIQVREG-SGAARLLAASGDPATDTEVRAERVLLAEL 264

Query: 239 EGGCQVPIGSY-AELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
            GGC VP+G++ +    G + L A V APDG + I    +G   + +++ +++AE LL  
Sbjct: 265 HGGCSVPLGTWTSRPSPGTLRLHAAVTAPDGGRQITATAQGPASEPDKLALTVAERLLAG 324

Query: 298 GAREILAE 305
           GA  ILAE
Sbjct: 325 GAARILAE 332


>UniRef50_Q2FTK7 Hydroxymethylbilane synthase n=3 Tax=Methanomicrobiales
           RepID=Q2FTK7_METHJ
          Length = 295

 Score =  289 bits (741), Expect = 8e-77,   Method: Composition-based stats.
 Identities = 111/305 (36%), Positives = 164/305 (53%), Gaps = 19/305 (6%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            LR+ TR S LA  QA  V   L     G+  ELV + T GD     PL ++GG+G+FV+
Sbjct: 2   PLRVGTRASELAKAQAVKVCTMLEDL--GVDTELVFISTAGDEQTGVPLHEIGGQGVFVR 59

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
            L+ AL++N+ D+AVHSMKD+P E P GL    I  R+ P D  V+++      L   + 
Sbjct: 60  ALDDALVQNKIDLAVHSMKDIPAERPYGLVTSAILARDSPCDYIVTDH-----ELDEITT 114

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GTSS RR  Q     P   IR LRGNV TRLSKL +GEYDAI+LA AGL+RL +     
Sbjct: 115 LGTSSTRRTAQCRRNLPWADIRPLRGNVNTRLSKLQSGEYDAIMLAKAGLERLSMTLDGY 174

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L P + +P+  QG + +  R  D    ++++ ++  +T +    ER +   + GGC  
Sbjct: 175 Q-LDPRVHVPSPNQGTIAVVSRT-DPDVTDIISKIDDPKTRMDTLLERRVMEMIGGGCFT 232

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGER-RGAPQDAEQMGISLAEELLNNGAREIL 303
           P+G Y +    +  + A V + +G +  R ER      DA++ G+ + E      A +++
Sbjct: 233 PLGIYCK----DRLMIAEVLSLEGDRHFRLERLVSDIDDADRFGLEVRER-----AGDLI 283

Query: 304 AEVYN 308
            E Y 
Sbjct: 284 REAYE 288


>UniRef50_D2RNT2 Porphobilinogen deaminase n=1 Tax=Acidaminococcus fermentans DSM
           20731 RepID=D2RNT2_ACIFE
          Length = 288

 Score =  289 bits (741), Expect = 8e-77,   Method: Composition-based stats.
 Identities = 118/297 (39%), Positives = 163/297 (54%), Gaps = 14/297 (4%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             L +ATR S LAL Q H V   L  +  G+  E+  + T GD      L K+GG+G+FV
Sbjct: 2   KKLIVATRGSRLALAQTHIVCRLLEEA--GVETEIRTITTAGDRDRIHALVKIGGRGIFV 59

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           +E+E  LL   ADIAVHS KD+P +   GL +     + DPRDA V      L+   AGS
Sbjct: 60  REIERELLSGEADIAVHSAKDLPYQLASGLVIAGTPSQADPRDALVLLKERKLE---AGS 116

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           +VGT S RR  +++   P+L+ R +RGNV TRL KL+ GEYDAI+LA+AG++RL L+   
Sbjct: 117 VVGTGSPRRIREISRVLPELVFRDIRGNVTTRLHKLERGEYDAIVLAMAGIQRLALDMEQ 176

Query: 184 RAALP--PEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
               P   E  +PA  QG +G+ECR  D     LL  ++  ET  R   ER + T ++  
Sbjct: 177 FQIRPLSTEQVIPAGCQGIIGVECRQKDRELVRLLQQISDPETWRRFQWERQLFTSMKVD 236

Query: 242 CQVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           C  P+G +   L  G + L A+V   DG    R  R G  ++ + +  SL EEL + 
Sbjct: 237 CSRPVGIHCRLLKSGRMELLAMV---DGK---RARRLGMEKEGKALCASLKEELYDR 287


>UniRef50_C0W553 Porphobilinogen deaminase n=2 Tax=Actinomycetales
           RepID=C0W553_9ACTO
          Length = 402

 Score =  287 bits (735), Expect = 4e-76,   Method: Composition-based stats.
 Identities = 129/387 (33%), Positives = 176/387 (45%), Gaps = 81/387 (20%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASH----PGLVVELVPMVTRGDVILDTPLAKVGGK 59
           + +R+ TR S LAL Q+  V   L  +       L VELVP+ TRGDV   T L+++GG 
Sbjct: 2   STVRLGTRGSALALTQSGLVARMLEQAAALAGQELHVELVPVRTRGDVD-PTALSQLGGV 60

Query: 60  GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD-SLDA 118
           G+F   L  ALL    D+AVHS KD+P     GL +  +  REDPRD   +      L  
Sbjct: 61  GVFATALREALLAGECDLAVHSYKDLPTAAVPGLRIAAVPAREDPRDVLCTRAATLGLHD 120

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--------------DNGEY 164
           LPAG+ VGT S RR  QL  +RPDL I  +RGNV TRL+++                 + 
Sbjct: 121 LPAGARVGTGSPRRSAQLLAQRPDLTIVPIRGNVPTRLARVVGSVVSADGPMGATAEPDL 180

Query: 165 DAIILAVAGLKRLGLESRIRAAL---------------------------PPEISLPAVG 197
           DA ILA++G++RLGLE      L                                LPA  
Sbjct: 181 DAAILALSGMRRLGLEDYASQPLAARCGARSQVEVQGIPDGGSAAGSPATTEPWMLPAAA 240

Query: 198 QGAVGIECRLDDSRTREL------LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAE 251
           QGA+ +E R  D  + EL      LA ++   T     AER++   L  GC  P+G+ A 
Sbjct: 241 QGALAVETR--DRVSCELPVLTVALALVDDPVTRACADAERSLMRCLAAGCAAPVGALAR 298

Query: 252 LID--------------------------GEIWLRALVGAPDGSQIIRGERRGAPQDAEQ 285
            +D                            I L ALV + DG+Q+ R    G  ++AE 
Sbjct: 299 PLDVAGEPAAGRDLPTEPGTALEPGPDQAPAICLEALVASLDGTQLRRASATGTLEEAED 358

Query: 286 MGISLAEELLNNGAREILAEVYNGDAP 312
           +G  +AE LL +GA +I     +  +P
Sbjct: 359 LGRCVAERLLADGAAQITDLQASKGSP 385


>UniRef50_C8WDJ7 Porphobilinogen deaminase n=3 Tax=Zymomonas mobilis
           RepID=C8WDJ7_ZYMMN
          Length = 308

 Score =  286 bits (733), Expect = 6e-76,   Method: Composition-based stats.
 Identities = 116/292 (39%), Positives = 162/292 (55%), Gaps = 7/292 (2%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHP--GLVVELVPMVTRGDVILDTPLAKVGGK 59
           +    R+ +R SPLAL QA  V   L A+H      V +VP+ T GD      LA +GGK
Sbjct: 1   MQLPFRLGSRGSPLALIQARSVASALCAAHSWSEDAVVIVPIRTSGDKNRHQALADIGGK 60

Query: 60  GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119
            L+ KEL++AL   + D AVHSMKDV    P  + +  +  RED  D  +     SL+ L
Sbjct: 61  ALWTKELDIALTTGQIDAAVHSMKDVETFRPSHISIAAMLPREDVHDRLIG--IPSLEVL 118

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179
           P    VGT+S RR  Q+   RPD+ I+ LRGN+ TRL KL N ++DA +LA AGL RLG 
Sbjct: 119 PYSGCVGTASPRRAAQIRRIRPDIEIKLLRGNIDTRLEKLANKQFDATLLAAAGLIRLGR 178

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
              +   +P +  LPA GQGA+GIE    DS   E ++ ++H+ T L V +ER +  RL 
Sbjct: 179 ND-VGYDVPLDQMLPAAGQGAIGIEALA-DSAAWEKVSIIDHYPTHLAVQSERQLLLRLN 236

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGA-PQDAEQMGISL 290
             C  PI  +AE+++  I LRA +   +G      ++  + P DA ++G  L
Sbjct: 237 ADCHSPIAVFAEILEKNIRLRACLYTENGKFSASIDKEISQPSDAFEVGSLL 288


>UniRef50_Q4PFH9 Putative uncharacterized protein n=1 Tax=Ustilago maydis
           RepID=Q4PFH9_USTMA
          Length = 770

 Score =  286 bits (733), Expect = 7e-76,   Method: Composition-based stats.
 Identities = 116/294 (39%), Positives = 154/294 (52%), Gaps = 39/294 (13%)

Query: 36  VELVPMVTRGDVILDTPLAKVGGKG--LFVKELEVALLENRADIAVHSMKDVPVEFPQGL 93
             +  M T GD  L +PL  +GG+G  ++ KELEVAL +   D  VH +KDVP   PQGL
Sbjct: 251 FPITSMSTAGDQNLRSPLYVIGGEGKAIWTKELEVALEQGAVDAIVHCLKDVPTALPQGL 310

Query: 94  GLVTICEREDPRDAFVSNN---YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRG 150
            L  + EREDPRDA V      Y  LD LP GS++GTSS+RR  QL  R P L+   +RG
Sbjct: 311 ELAAVLEREDPRDALVVKAGLPYKVLDELPVGSVIGTSSVRRVAQLRRRYPHLVFSDVRG 370

Query: 151 NVGTRLSKLD--NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRL- 207
           N+ TRL+KLD  NG Y A+ILA AGL RL + +RI A L   + L +VGQG++ IE R  
Sbjct: 371 NINTRLAKLDAPNGPYTALILAAAGLVRLNMHARITAFLSSPVLLHSVGQGSLAIEVRTP 430

Query: 208 ---------DDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIW 258
                     D+R REL+ ++       R  AER++   LEGGC +P+G      D    
Sbjct: 431 PEGADPTTNRDARIRELIRSIGDWRATFRAEAERSLLKELEGGCSIPVGVETRFDD---- 486

Query: 259 LRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYNGDAP 312
                           +  G   +A    I+L ++ +  G     AE+ NG  P
Sbjct: 487 --------------HDQVEGQRSEA----IALVDDFVTQGNAGAKAELPNGGMP 522



 Score = 48.2 bits (114), Expect = 4e-04,   Method: Composition-based stats.
 Identities = 22/58 (37%), Positives = 29/58 (50%), Gaps = 4/58 (6%)

Query: 253 IDGEIWLRALVGAPDGSQIIRGERR---GAPQDAEQMGISLAEELL-NNGAREILAEV 306
               + L A+V + DGSQ  R          +DA ++GI +A EL    GAR IL EV
Sbjct: 600 EGRTLHLDAIVVSLDGSQESRYSASKHCTTVKDARELGIHVAHELAHKKGARAILEEV 657


>UniRef50_B4D5X7 Porphobilinogen deaminase n=1 Tax=Chthoniobacter flavus Ellin428
           RepID=B4D5X7_9BACT
          Length = 307

 Score =  282 bits (723), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 109/277 (39%), Positives = 151/277 (54%), Gaps = 14/277 (5%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPL---AKVGGKG 60
             + + TR S LA+ Q       L A+ P + +E    VTRGD  LD  L    + GGKG
Sbjct: 2   KSIILGTRASALAVAQVELTTKALAAAFPAMQIERREFVTRGDKKLDLSLLRANEAGGKG 61

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LF KELE ALL    D+AVHS+KD+P   P GL +  + ER    D  ++    +L  LP
Sbjct: 62  LFTKELEDALLNGSIDVAVHSLKDLPGHNPPGLDITAVLERAPTADVLITKQPQTLLDLP 121

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-DNGEYDAIILAVAGLKRLGL 179
            G ++GTSS+RR  QL  RRPD+ +   RGNV TRL KL +  +   IILA AGL+RLG 
Sbjct: 122 QGVLLGTSSVRRARQLQWRRPDVRVEEWRGNVQTRLRKLAERDDVTGIILAQAGLERLGH 181

Query: 180 E----------SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVT 229
           +           +       E  LPA+GQGA+ ++ R D +    +L  ++H ET L + 
Sbjct: 182 DLSAGRLETEHGKFYVTSLAEDLLPAIGQGAIALQSRADRAEVAAVLQKIDHRETHLAIR 241

Query: 230 AERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAP 266
           AER +   L G C +P+G   +L+ G I +RA++  P
Sbjct: 242 AERELQRLLAGDCALPVGVRTKLLPGGIAMRAILFGP 278


>UniRef50_B5JN62 Porphobilinogen deaminase n=1 Tax=Verrucomicrobiae bacterium DG1235
           RepID=B5JN62_9BACT
          Length = 291

 Score =  280 bits (718), Expect = 4e-74,   Method: Composition-based stats.
 Identities = 112/290 (38%), Positives = 143/290 (49%), Gaps = 16/290 (5%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67
           IATR+SPLA+ Q H  K+      P  V  +  MVT GD   +  L K GGKGLF KELE
Sbjct: 10  IATRKSPLAMAQTHLAKELFQRGMPDAVFRIEKMVTTGDKRQEWSLEKQGGKGLFTKELE 69

Query: 68  VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127
            ALLE RAD AVHS KD+P E P+GL L     R+   D  +  +      L     + T
Sbjct: 70  DALLEGRADFAVHSAKDLPSEMPKGLALAGFLPRQTCEDVLILRDGVESPKL-----IAT 124

Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG---LESRIR 184
            S RR+ QL    P      +RGNV TRL+K+  G+ DA +LA AGL RLG    E    
Sbjct: 125 GSPRRRIQLRYLFPKAEFTEIRGNVDTRLTKIARGDADATVLASAGLNRLGIESWEGVTF 184

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L  +  +PAVGQ AV I+CR +D  T     A    ETA+ V  ER+    L GGCQV
Sbjct: 185 RKLTLDECVPAVGQAAVAIQCREEDVDT---FRAHLDEETAIAVNLERSFLEELGGGCQV 241

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
                   + G + +        G ++    +       EQ+   L E+L
Sbjct: 242 AFAVN--YVGGRLRI---YHKQCGKEVRDLPQEYVATHYEQIAAKLIEQL 286


>UniRef50_A2BFN7 Hydroxymethylbilane synthase (Fragment) n=6 Tax=Coelomata
           RepID=A2BFN7_DANRE
          Length = 247

 Score =  279 bits (715), Expect = 8e-74,   Method: Composition-based stats.
 Identities = 112/229 (48%), Positives = 144/229 (62%), Gaps = 4/229 (1%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62
             V+R+ TR+S LA  Q   V   L   +P + +E+V M T GD ILDT L+K+G K LF
Sbjct: 19  SRVIRMGTRKSQLARIQTDSVAGTLKQLYPDVHLEIVAMSTIGDKILDTALSKIGEKSLF 78

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDAL 119
            KELE AL  N  DI VHS+KD+P   P G  +  I ERE+P DA V +      +LD+L
Sbjct: 79  TKELENALERNEVDIVVHSLKDLPTSLPPGFTIGAILERENPHDAVVLHPKNAGLTLDSL 138

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLG 178
           P  S++GTSSLRR  QL +R P L   ++RGN+ TRL KLD   +Y AIILA AGLKR+G
Sbjct: 139 PEKSVIGTSSLRRAAQLKKRFPQLEFENIRGNLNTRLKKLDEKDDYAAIILAAAGLKRMG 198

Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALR 227
            ESRI   L PE  + AVGQGA+ +E R  D    E+++ L+H +T LR
Sbjct: 199 WESRISQVLGPEDCMYAVGQGALAVEVRAQDKDILEMVSVLHHPDTVLR 247


>UniRef50_Q97B26 Probable porphobilinogen deaminase n=2 Tax=Thermoplasma
           RepID=HEM3_THEVO
          Length = 297

 Score =  278 bits (713), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 86/266 (32%), Positives = 136/266 (51%), Gaps = 6/266 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           ++I TR S LA+ QA+ V   L A   G+  E+V   + GD+    P+  +G  G+FV++
Sbjct: 3   IKIGTRPSNLAVAQANMVASSLEAI--GIDTEIVKHRSAGDIDTKNPIYSIGKTGVFVQD 60

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L   +L    D+AVHS KD+P E    L +    +R    DA VS     L +LP  + V
Sbjct: 61  LNNMILRGEIDVAVHSAKDIPSEIENRLTIAATLKRGSFNDALVSKYD--LRSLPISAKV 118

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS+RR  QL   R DL   ++RGN+ TR++K+     DAI++A A ++RLGL      
Sbjct: 119 GTSSIRRIFQLKYARQDLKFENIRGNIETRIAKMSELGLDAIVMAEAAIQRLGLNVEYS- 177

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L     +PA  QG + +  + + +  R++L  +N   T   +  ER++  +L+ GC  P
Sbjct: 178 KLDENKFVPAPNQGIIAVVSKKEGT-VRKILEEINDENTFEEMQIERSVVQQLKLGCSTP 236

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQI 271
           +G  +        + A   +  G  +
Sbjct: 237 VGILSRPSGKGHKIIAQFFSMQGDDV 262


>UniRef50_Q1GP41 Porphobilinogen deaminase n=7 Tax=Sphingomonadales RepID=HEM3_SPHAL
          Length = 315

 Score =  278 bits (712), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 136/306 (44%), Positives = 172/306 (56%), Gaps = 10/306 (3%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGL--VVELVPMVTRGDVILDTPLAKVGGKG 60
           DN LRI TR SPLA+ QAH     L+A+H      +E+VPM   GD I D  LA+VGGK 
Sbjct: 8   DNPLRIGTRASPLAMAQAHMAAAALIAAHGLAMAALEIVPMTATGDRIQDRALAEVGGKA 67

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLD 117
           L+ +EL+ AL     D+AVHS+KDV         L  + ER DPRD  V         + 
Sbjct: 68  LWTRELDAALDAGTIDVAVHSLKDVETLRDARFFLGAMLERADPRDRLVVREGIAAQKIS 127

Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177
            LP G+ +GTSS RR  Q+   RPDL    LRGNV TRL+KL  GE DA +LA AGL+RL
Sbjct: 128 ELPHGARLGTSSPRRAAQVRRLRPDLDTVLLRGNVATRLAKLAAGEADATLLAAAGLERL 187

Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237
           G+   I A    E+ LPA  QGA+GIECR DD+ T  LLAA++H  T   V AERA+   
Sbjct: 188 GMHD-IGAVQGTELLLPAASQGAIGIECRADDAATIALLAAIDHAPTHRAVAAERALLAV 246

Query: 238 LEGGCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
           L G C+ P+ +YAE   DG + L A + + DG+  + G       DA  +  +L   LL 
Sbjct: 247 LGGDCRSPVAAYAEWQADGVLRLDAEIFSEDGADHVAGHVIVT--DAGVVA-ALGHRLLA 303

Query: 297 NGAREI 302
                I
Sbjct: 304 EAPPSI 309


>UniRef50_Q8I5V3 Porphobilinogen deaminase n=6 Tax=Plasmodium RepID=Q8I5V3_PLAF7
          Length = 435

 Score =  277 bits (710), Expect = 3e-73,   Method: Composition-based stats.
 Identities = 94/356 (26%), Positives = 162/356 (45%), Gaps = 61/356 (17%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHP----GLVVELVPMVTRGDVILD-TPLAKV 56
           + + + I TR SPLAL Q+  V+ K+M+        + V    + T GD ILD   +   
Sbjct: 58  IKDEIIIGTRDSPLALKQSEKVRKKIMSYFKKMNKNINVTFKYIKTTGDNILDSKSVGLY 117

Query: 57  GGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSL 116
           GGKG+F KEL+  L+    D+ VHS+KDVP+  P  + L    +R+   DAF+S  Y S+
Sbjct: 118 GGKGIFTKELDEQLINGNVDLCVHSLKDVPILLPNNIELSCFLKRDTINDAFLSIKYKSI 177

Query: 117 DALPAGS------------------------IVGTSSLRRQCQLAERRPDLIIRSLRGNV 152
           + +                             +GTSSLRR+ Q+  R  ++ + ++RGN+
Sbjct: 178 NDMNTVKSVSKTEDIHHINKKDSDHNNDTLCTIGTSSLRRRSQIKNRYKNIYVNNIRGNI 237

Query: 153 GTRLSKLDNGEYDAIILAVAGLKRL--------------------------------GLE 180
            TR+ KL NGE DA+I+A+ G++RL                                 L 
Sbjct: 238 NTRIEKLYNGEVDALIIAMCGIERLIKKANLKHLLKNKEQKNICQPFLLKCNNKKCIDLC 297

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
                 L   +  PA+GQG + +     +     LL  +N+ ++ +    ER+    ++G
Sbjct: 298 HVNIQKLNKNLIYPALGQGIIAVTSHKKNYFISSLLKNINNKKSEMMAQIERSFLYHIDG 357

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
            C +PIG Y  + + +I+L  ++    G    +  ++    + +++G + A ++  
Sbjct: 358 NCMMPIGGYTNMRNEDIYLHVIINDIHGYNKYQVTQKDTLYNYKEIGPNAAIKMKE 413


>UniRef50_C5C5B3 Porphobilinogen deaminase n=6 Tax=Actinomycetales
           RepID=C5C5B3_BEUC1
          Length = 334

 Score =  277 bits (709), Expect = 4e-73,   Method: Composition-based stats.
 Identities = 120/294 (40%), Positives = 155/294 (52%), Gaps = 25/294 (8%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHP-----GLVVELVPMVTRGDVILDTPLAKV 56
               LR+ TR S LA  Q+ +  + + A         + VELV + T GD +L   LA +
Sbjct: 18  STRTLRVGTRASALATTQSEWAGEAIAARVAAATGSDVEVELVRVTTTGD-VLTGSLASM 76

Query: 57  GGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSL 116
           GG G+FV  L  ALL+ R D+AVHS+KD+P     GL L  + +REDPRD   +     L
Sbjct: 77  GGTGVFVTALREALLDGRCDVAVHSLKDLPTAAAPGLVLGAVPQREDPRDVLCARAGAGL 136

Query: 117 DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGL 174
             LPAG  VGT S RR  QL   RPDL I  +RGNV TRLS++    G+ DA++LA AGL
Sbjct: 137 ADLPAGGRVGTGSPRRAAQLRRARPDLEIVDIRGNVDTRLSRISPGKGDLDAVVLARAGL 196

Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECR-LDDSRTRELLAALNHHETALRVTAERA 233
            RLG    +  AL   + +PA GQGA+ +E            L A +   T L VTAERA
Sbjct: 197 ARLGRLDAVTEALDAGVMVPAPGQGALAVEAVDAAPDWLLAGLRAFDDAPTRLAVTAERA 256

Query: 234 MNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMG 287
           M  RLE GC  P+G+ A L   ++ LR  VG                +DAE +G
Sbjct: 257 MLARLEVGCSAPVGALATLAGSQLLLRTSVG----------------EDAEDLG 294


>UniRef50_Q9Y9J0 Probable porphobilinogen deaminase n=1 Tax=Aeropyrum pernix
           RepID=HEM3_AERPE
          Length = 307

 Score =  276 bits (708), Expect = 4e-73,   Method: Composition-based stats.
 Identities = 106/294 (36%), Positives = 158/294 (53%), Gaps = 8/294 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVV--ELVPMVTRGDVILDTPLAKVGGKGLFV 63
           +R+A R S L+L Q     ++L + + G+ +  E+V + + GDV  D PL  +G  G+F 
Sbjct: 3   VRVAARGSRLSLLQVEQALEEL-SRYAGVSMHWEVVRVKSAGDVWSDRPLESIGVVGVFT 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQG-LGLVTICEREDPRDAFVSNNYD-SLDALPA 121
           +E++ A+    ADIAVHS+KD+P     G L +V I  R   RDA +S      ++ L  
Sbjct: 62  REVDRAVASGAADIAVHSLKDMPTSGYGGPLKIVYIASRPSARDALISRQGPGRVEDLEP 121

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           GS +GTSS RR+       P + + +LRGN+ TRL KL  G YDAII + AGL RLG++ 
Sbjct: 122 GSTLGTSSARRRALSLHYNPRIRVENLRGNLDTRLRKLREGLYDAIIASEAGLIRLGVDV 181

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
                L P    PA GQG V +  R+  S   ++L  L+         AER +      G
Sbjct: 182 EYT-PLDPSYFPPAPGQGFVAVVARVG-SNVEKMLRDLDKPPWWHVAWAERGVLEGARAG 239

Query: 242 CQVPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
           C+ P+ +YAE +    + + A   +PDGS+       G  ++A ++G+SL EEL
Sbjct: 240 CRTPVAAYAEPLGRSMVRVTAAALSPDGSRAYWARAEGRIEEARRIGVSLGEEL 293


>UniRef50_C1XV35 Porphobilinogen deaminase n=2 Tax=Meiothermus RepID=C1XV35_9DEIN
          Length = 304

 Score =  275 bits (704), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 114/266 (42%), Positives = 158/266 (59%), Gaps = 10/266 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RIATR S LA WQA +V  +L     G+   LV + T+GD       +++ G+G F K 
Sbjct: 4   VRIATRGSRLARWQAEWVAAQLQDQ--GIASTLVIVETQGDRER-VAFSQMQGQGFFTKA 60

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP----- 120
           ++ A+ E RAD+AVHS+KD+P     GL L  I  REDPR+A +          P     
Sbjct: 61  VQDAVREGRADLAVHSLKDLPSAPTPGLVLAAIPIREDPREALLVLPSAWDAQAPALPLA 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ VG+S++RRQ QLA+ RPDL +  LRGNV TR+ KL +G Y+AI+LA AGLKRLGL+
Sbjct: 121 PGARVGSSAVRRQAQLAQLRPDLKLLELRGNVPTRVEKLQSGGYEAILLAWAGLKRLGLD 180

Query: 181 --SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
                   L P   +PA GQGA+ +ECR +D++ R +L  L+     L V  ER +  RL
Sbjct: 181 LGGLAVRLLEPREFVPAPGQGALALECREEDTQLRGVLQGLDDPTARLTVGIERGLMARL 240

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVG 264
           +GGCQ+ +G+ A+ + G   L A  G
Sbjct: 241 QGGCQLALGASAQRVQGGWQLLAWYG 266


>UniRef50_Q93A65 Porphobilinogen deaminase n=1 Tax=uncultured bacterium
           RepID=Q93A65_9BACT
          Length = 299

 Score =  273 bits (700), Expect = 4e-72,   Method: Composition-based stats.
 Identities = 115/265 (43%), Positives = 155/265 (58%), Gaps = 11/265 (4%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +R+ATR S LALWQA +V  +L+    G  VELV + T+GD     P A++ G+G F K 
Sbjct: 4   VRLATRGSRLALWQAEWVAKQLVQQ--GAEVELVVVETQGDR-EKRPFAQMQGQGFFTKA 60

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN-----NYDSLDALP 120
           ++ A+LE RAD AVHS KD+P   P GL +  +  REDPR+  +              L 
Sbjct: 61  VQEAVLEGRADFAVHSYKDLPSARPAGLEIAAVPPREDPRELLLVRLQAVDQVAPGLPLR 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
           AG+ VG+S+ RRQ QLA  RPDL +  LRGNV TR+ KL  GEYDA++LA AG++RLGL+
Sbjct: 121 AGARVGSSAARRQAQLAHLRPDLSLLELRGNVLTRVEKLRQGEYDAVLLAYAGVRRLGLD 180

Query: 181 --SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
                   LPP + +PA  QGA+ +ECR DD R R LL  L+     +R      +  RL
Sbjct: 181 LSPFHWQVLPPTLLVPAPAQGALALECRQDDKRLRPLLEPLDDPSAGVRCGGA-GLMARL 239

Query: 239 EGGCQVPIGSYAELIDGEIWLRALV 263
            GGCQ+ +G+ A+     + L A  
Sbjct: 240 AGGCQLALGALAQETPEGLQLLAWY 264


>UniRef50_Q0RS16 Porphobilinogen deaminase 1 (PBG 1) (Hydroxymethylbilane synthase
           1) (HMBS 1) (Pre-uroporphyrinogen synthase 1) n=2
           Tax=Frankia RepID=Q0RS16_FRAAA
          Length = 402

 Score =  273 bits (699), Expect = 5e-72,   Method: Composition-based stats.
 Identities = 121/366 (33%), Positives = 168/366 (45%), Gaps = 77/366 (21%)

Query: 13  SPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLE 72
           S LAL Q+  +  +L     G  V+LVP+VT GD      ++++GG G+FV  L  ALL 
Sbjct: 36  SALALTQSGMIAAQLRERV-GCAVDLVPIVTAGDRS-PAEISQIGGTGVFVSALRDALLA 93

Query: 73  NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRR 132
              D+AVHS+KD+P   P GL L  +  RED RD  VS +   L AL  G+ V T + RR
Sbjct: 94  GEIDLAVHSLKDLPTATPPGLVLAAVPTREDTRDVLVSPSGRGLAALGPGARVATGAPRR 153

Query: 133 QCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEIS 192
             QL        + ++RGNV TRL K  +GE DA++LA AGL RL     +   L PE+ 
Sbjct: 154 AAQLRALGLGFDVVAIRGNVDTRLKKAIDGEVDAVVLAYAGLARLDRLDAVTEILDPEVM 213

Query: 193 LPAVGQGAVGIE------------------------------------------------ 204
           LPA GQGA+ +E                                                
Sbjct: 214 LPAPGQGALAVECAAEAGLRLAGPARALVAAGAGDHADGDRPGAEAGRDGRGRGPDVGRN 273

Query: 205 ---CRLD-----DSRTRELLA-ALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID- 254
               R D     D    ELL   L+   +++ + AERA    +E GC  P+G+ A     
Sbjct: 274 SGQTRSDHGQPLDGGLAELLRFVLDDASSSVAIRAERAFLAGIEAGCTAPVGALAVAEPA 333

Query: 255 -----------------GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
                            G + LRA+V APDGS ++R +  G+  D E +G  LA++LL+ 
Sbjct: 334 PAAAVGTVAPAGDASPAGRLRLRAVVAAPDGSTVLRRDVTGSAVDPEALGQRLADDLLSA 393

Query: 298 GAREIL 303
           GA  ++
Sbjct: 394 GAHSLM 399


>UniRef50_B0WMK9 Porphobilinogen deaminase n=1 Tax=Culex quinquefasciatus
           RepID=B0WMK9_CULQU
          Length = 474

 Score =  273 bits (698), Expect = 8e-72,   Method: Composition-based stats.
 Identities = 96/243 (39%), Positives = 133/243 (54%), Gaps = 29/243 (11%)

Query: 13  SPLALWQAHYVKDKLMASHPGLVVELV------------------------PMVTRGDVI 48
           S LAL Q  YV   L   +P +V E+                          M T GD +
Sbjct: 167 SKLALIQTKYVISCLQKLNPDVVYEIRKYFQHVHLCWHVPSYLLAFFLSPDTMTTVGDRV 226

Query: 49  LDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAF 108
           L+  L K+G K LF K+LE AL     D  VHS+KD+P   P G+ +  + ER+DPRDA 
Sbjct: 227 LNKSLPKIGEKSLFTKDLEDALRTGGVDFVVHSLKDLPTALPLGMAIGAVLERDDPRDAL 286

Query: 109 V---SNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG--E 163
           V   ++   +L  LP GS+VGTSSLRR  QLA +  ++++  +RGN+ TRL+KLD    +
Sbjct: 287 VLNEAHRGRTLSTLPKGSVVGTSSLRRSAQLARKYENVVVCDIRGNLNTRLAKLDADGSK 346

Query: 164 YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHE 223
           +  IILA AGL R+G  +R+   + P   L AVGQGA+ +ECR +D    ++L+ L H E
Sbjct: 347 FAGIILAQAGLVRMGWNARVSQVIEPGEILYAVGQGALAVECRSNDEYILDMLSKLCHLE 406

Query: 224 TAL 226
           T  
Sbjct: 407 TQC 409


>UniRef50_Q83H95 Porphobilinogen deaminase n=2 Tax=Tropheryma whipplei
           RepID=Q83H95_TROW8
          Length = 321

 Score =  268 bits (687), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 108/331 (32%), Positives = 153/331 (46%), Gaps = 42/331 (12%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            LRI TR S LA  Q   V+  +      L  + V + T      D         G FV 
Sbjct: 3   PLRIGTRSSLLATAQTAQVQKTMRDVFL-LDTQQVLIQTGSVRRRD---------GSFVA 52

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
            L  ALLE   D+AVHS+KD+P+   +G  +  +  REDP D   +    +L  LP+G+ 
Sbjct: 53  ALRTALLEGECDLAVHSLKDIPIAPHEGTLITAVLPREDPCDVLCARKDLTLTTLPSGAK 112

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGT+S RR+ Q+   RPDL + SLRGN+  RL  LD    DAI+L+ AGLKR+  E  I 
Sbjct: 113 VGTASARRRAQILNFRPDLDVVSLRGNIDKRLIHLDT--LDAIVLSAAGLKRIDREDAIT 170

Query: 185 AALPPEISLPAVGQGAVGIE-CRL--DDSRTRELLA-ALNHHETALRVTAERAMNTRLEG 240
            +        A GQG++ IE CR   DD + R  +   L++    +  TAER + + L+ 
Sbjct: 171 ESFDIHDWPTAAGQGSLAIEVCRAQLDDPQNRVAVTYRLDNPMARVTTTAERGVLSLLQA 230

Query: 241 GCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIR------------------------G 274
            C  PI  +A     D  + L A V + DG                              
Sbjct: 231 DCFSPIAVHAVYTANDKSLRLHAKVFSRDGKIFCESIRFARLVKQLTDTNQNHTKNSGSD 290

Query: 275 ERRGAPQDAEQMGISLAEELLNNGAREILAE 305
           +   A + A  +  ++ +ELL+  AREIL +
Sbjct: 291 DIGNALEVAMTLAKTVVDELLSKNAREILKQ 321


>UniRef50_A7BMK1 Porphobilinogen deaminase n=1 Tax=Beggiatoa sp. SS
           RepID=A7BMK1_9GAMM
          Length = 211

 Score =  267 bits (683), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 124/211 (58%), Positives = 149/211 (70%), Gaps = 1/211 (0%)

Query: 99  CEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSK 158
             RE+P DAFVSN Y +L ALP G+IVGTSSLRRQ QL   RPDL IRSLRGNVGTRLSK
Sbjct: 1   MRREEPFDAFVSNTYATLAALPEGAIVGTSSLRRQSQLLAHRPDLQIRSLRGNVGTRLSK 60

Query: 159 LDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAA 218
           LDNG+YDAI+LA  GLKRLGL  RIR  +   I LPA+GQGA+GIECR DD  TR+ +  
Sbjct: 61  LDNGDYDAIVLAAVGLKRLGLVERIREIIDSTIMLPAIGQGAIGIECRQDDLETRQHIDN 120

Query: 219 LNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERR 277
           LN  +T   V AERA+N  LEGGCQVPI  YAE+   E + +R LVG  +G  I+R   +
Sbjct: 121 LNDPDTQDCVIAERALNESLEGGCQVPIAGYAEIQSSENLTMRGLVGDIEGQHILRHNLQ 180

Query: 278 GAPQDAEQMGISLAEELLNNGAREILAEVYN 308
           GA   A ++G SLA+ LL  GA +IL ++ +
Sbjct: 181 GARHLAAELGKSLAKVLLTQGAAQILEKLKD 211


>UniRef50_UPI000038E213 porphobilinogen deaminase n=1 Tax=Ferroplasma acidarmanus fer1
           RepID=UPI000038E213
          Length = 285

 Score =  265 bits (679), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 91/263 (34%), Positives = 139/263 (52%), Gaps = 10/263 (3%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            + I TR S LAL QA+ VKD L +   G  V +    + GD   + PL ++   G+FV 
Sbjct: 2   PVTIGTRNSKLALIQANSVKDALESR--GYEVNIKSYTSAGDSNKNIPLYRMSSTGVFVD 59

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           EL   +L+   D+AVHS KD+P    +GL +  +  R+D RD  +S     L+ + AGS+
Sbjct: 60  ELNERVLKGEIDLAVHSAKDIPSNIQKGLEITAVTGRDDFRDVLISR--TPLEEMTAGSV 117

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GTSS+RR  Q     P++ +  +RGN+ TR+SK    +Y  II+A+A  KR+ L+    
Sbjct: 118 IGTSSMRRIRQAMTVNPEITVSDIRGNIDTRISKYTEKKYTGIIIAMAAYKRMKLDIE-H 176

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L  E  LPA  QG + I  + +   +  +   +N  ET   +  ER + T L  GC +
Sbjct: 177 FILSEEQFLPAPNQGIIAIVGKSNSPASI-ISGEINDRETYRDMKNERFIATSLNLGCSM 235

Query: 245 PIGSYAELIDGEIWLRALVGAPD 267
           P+G  ++  DG+I  R    + D
Sbjct: 236 PVGILSK--DGKIKTR--FYSLD 254


>UniRef50_Q04X38 Bifunctional porphobilinogen deaminase/uroporphyrinogen synthase
           n=4 Tax=Leptospira RepID=Q04X38_LEPBL
          Length = 542

 Score =  261 bits (668), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 89/279 (31%), Positives = 127/279 (45%), Gaps = 32/279 (11%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +  VL+IA+R+S LA  Q + V D L    P + +EL      GD+ L TPL K+G +G+
Sbjct: 1   MSRVLKIASRKSALAKLQTYLVLDALKKKFPNIQIELHFREASGDLDLQTPLWKMGTRGV 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F ++L   L+E + D+ +HS KD+ +E   G  +V + +R D RD  +          P+
Sbjct: 61  FTQDLTKDLVEKKVDLVIHSWKDLDLEGHSGTTIVGVLDRADQRDVLLWKKSSLSKNFPS 120

Query: 122 GSIVGTSSLRRQCQLAERRPD----------LIIRSLRGNVGTRLSKLDNGEYDAIILAV 171
              + TSS RR+  L +   +          LI   +RGN+ TR+ K  N + D ++LA 
Sbjct: 121 ELKIQTSSPRREYNLKKFLNNSLPSRYKNSSLIFLPVRGNIQTRIRKWRNSDSDGLVLAK 180

Query: 172 AGLKRL----------------------GLESRIRAALPPEISLPAVGQGAVGIECRLDD 209
           A L RL                       LE  I   LP  +S  A  QGA+  E R DD
Sbjct: 181 AALDRLLSEDFLNSNELEYQEIRKFLKEILEESIFQVLPLSLSPSAPAQGAIAAEVRTDD 240

Query: 210 SRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGS 248
                 + AL+  E    V  ER    R  GGC   IG 
Sbjct: 241 EWALGFVRALSKPEVVSAVEEERNTLKRFGGGCHQKIGV 279


>UniRef50_A9V9E0 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V9E0_MONBE
          Length = 643

 Score =  261 bits (667), Expect = 3e-68,   Method: Composition-based stats.
 Identities = 99/206 (48%), Positives = 124/206 (60%), Gaps = 6/206 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR S LA+WQ  +V ++L  +HPG+   +VP+ T GD  L   L K    G+F   
Sbjct: 417 IRIGTRSSVLAMWQTRWVVERLTRAHPGVRFSVVPLSTVGDANLTLDLNKFSTTGIFTDA 476

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS----LDALPA 121
           L  ALL    DI VHS+KD+P     G  L  I  REDPRD  V ++  S    L  LPA
Sbjct: 477 LVRALLAQEVDILVHSLKDLPSTISPGTQLAAIGPREDPRDVVVFHHRHSEIKDLAQLPA 536

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN--GEYDAIILAVAGLKRLGL 179
           G++VGTSS RR+ QLA   P L    +RGNV TRL KLD+    YDA+ LA AGL RLGL
Sbjct: 537 GAVVGTSSTRRRAQLAAAYPQLRFAPVRGNVMTRLRKLDDPANGYDALCLAAAGLIRLGL 596

Query: 180 ESRIRAALPPEISLPAVGQGAVGIEC 205
           E+RI   LP  +S  A+GQGA+GI+ 
Sbjct: 597 EARIGQFLPLTVSRHAIGQGALGIQV 622


>UniRef50_UPI0001C31A39 porphobilinogen deaminase n=1 Tax=Conexibacter woesei DSM 14684
           RepID=UPI0001C31A39
          Length = 314

 Score =  259 bits (662), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 131/292 (44%), Positives = 168/292 (57%), Gaps = 13/292 (4%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           +VLRI TR S LAL QA +V   L     G  VE++P+ T GD         +G K  +V
Sbjct: 2   SVLRIGTRASALALVQAEHVASLLRDG--GAQVEVIPITTSGDRGR-----LLGDKSRWV 54

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KELE ALL +  D+AVHS KDVP E P G  L  +  R D RDA       SL+ LP G+
Sbjct: 55  KELEAALLADEVDVAVHSAKDVPAELPDGFVLAGVPARADARDALCG--AASLEQLPDGA 112

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           +VGTSSLRR  +L   RPDL + +LRGNV TRL KL +G+  AI+LAVAGL+RL   + I
Sbjct: 113 VVGTSSLRRAAELRALRPDLGVVALRGNVDTRLRKLADGQAAAIVLAVAGLERLDRGAAI 172

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
            A    +  +PA GQGA+ +E R DD R R   AA+   + A  + AERA+  RL   C 
Sbjct: 173 GAV--LDQLVPAPGQGALALETRADDDRARAAAAAITDADAAACLAAERALVRRLGATCH 230

Query: 244 VPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAPQ-DAEQMGISLAEE 293
            P+G++A    DG + LR+ VG PDGS  +R E   A   D E  G++    
Sbjct: 231 TPLGAHAVRTADGGLRLRSFVGLPDGSAWLRDELSAAAGIDPETFGVAAGTR 282


>UniRef50_A5K0J5 Porphobilinogen deaminase, putative n=1 Tax=Plasmodium vivax
           RepID=A5K0J5_PLAVI
          Length = 341

 Score =  259 bits (662), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 90/322 (27%), Positives = 144/322 (44%), Gaps = 69/322 (21%)

Query: 45  GDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDP 104
           GD ILD  +   GGKG+F KEL+  L++    I VHS+KDVP+E P+ + L    +R+  
Sbjct: 2   GDHILDKKVGLFGGKGIFTKELDEQLIKKNVHICVHSLKDVPMELPEHVQLSCFLKRDTI 61

Query: 105 RDAFVSNNYDSLDALPAGS---------------------------------------IV 125
            DAF+S  Y +L+ +                                            +
Sbjct: 62  NDAFLSVKYATLEDMNKRKMANKVEEESDQEKGTIQQMTNQGLKRDNCEGDKCTNFIPTI 121

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSSLRR  Q+     ++ ++++RGN+ TR++KL NG+YDAII+A  GL+RL  +  +R 
Sbjct: 122 GTSSLRRSSQIKYTYKNVAVKNVRGNINTRIAKLCNGQYDAIIIAKCGLERLLTKKVVRN 181

Query: 186 AL------PPEISL------------------------PAVGQGAVGIECRLDDSRTREL 215
            +      PPE  L                        PA+ QG + +    +D  T  +
Sbjct: 182 IIRGKGKVPPEKFLLNHNDMETNLRLLRIQQINRRTIYPALCQGIIAVTSHKNDVDTSNI 241

Query: 216 LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE 275
           L  +N  +  +    ER+   ++EG C +PIG YA+++ GEI   A++    G +     
Sbjct: 242 LKNINDEKAQIMANVERSFLYQIEGNCMMPIGGYAQIVGGEIVFNAVINDTHGREKYHVR 301

Query: 276 RRGAPQDAEQMGISLAEELLNN 297
             G  Q+   +    A ++   
Sbjct: 302 EVGTVQNCNNIAAMAATKMKEK 323


>UniRef50_B0SF66 Bifunctional porphobilinogen deaminase/uroporphyrinogen synthase
           n=2 Tax=Leptospira biflexa serovar Patoc
           RepID=B0SF66_LEPBA
          Length = 511

 Score =  250 bits (640), Expect = 4e-65,   Method: Composition-based stats.
 Identities = 88/314 (28%), Positives = 137/314 (43%), Gaps = 37/314 (11%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   ++I  R S L+  Q H V + L   +  L  E +   + GD  L TPL + GG+G+
Sbjct: 1   MSETIKIGGRSSLLSRIQIHTVTNALKEKNKDLNFETIFRESSGDKDLTTPLWQFGGQGI 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F K+L+  LL ++ DI +HS KD+ ++  +   L+ +  RED RD  +      ++ LP 
Sbjct: 61  FTKDLQEDLLNHKVDIVIHSYKDMDLKERKETTLIPVLPREDVRDVLLFKKNKWIN-LPN 119

Query: 122 GSIVGTSSLRRQC----QLAERRP------DLIIRSLRGNVGTRLSKLDNGEYDAIILAV 171
              + TSS RR+      L    P      ++ I S+RGN+ TRL K  + E   I++A 
Sbjct: 120 EITILTSSPRREYHIKEFLRNYFPTPINNFEIKIESVRGNIQTRLRKYLDHESGGILVAK 179

Query: 172 AGLKRL----------------------GLESRIRAALPPEISLPAVGQGAVGIECRLDD 209
           A L R+                       +   +   LP  I   A  QGA+  E R +D
Sbjct: 180 AALDRILNFQDPDQLLPELKEIQQLIKDTMNVSLFMVLPSSIFPSAPAQGALCAEIRKED 239

Query: 210 SRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYA--ELIDGEIWLRALVGAPD 267
                LL+ ++  ET L    ER + +R  GGC   IG            ++R +    D
Sbjct: 240 KHLETLLSKISDSETNLTTNEEREILSRYGGGCHQKIGVTVLHREYGKVCFIRGI--TED 297

Query: 268 GSQIIRGERRGAPQ 281
           G  +   E   +P 
Sbjct: 298 GQILQTKELSESPN 311


>UniRef50_C0EAN0 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum
           DSM 5476 RepID=C0EAN0_9CLOT
          Length = 292

 Score =  250 bits (638), Expect = 6e-65,   Method: Composition-based stats.
 Identities = 90/294 (30%), Positives = 131/294 (44%), Gaps = 18/294 (6%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             + I   Q+ L+   A ++   L + HP L  ELVP+   G     T         L  
Sbjct: 13  EKIHIGCAQNELSRNFADHLAQCLHSYHPELTAELVPIKNTGADEEPT---------LVA 63

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           + LE AL++ R D+AV+   D+P+E    L +V I  RED RDA V          P  S
Sbjct: 64  RRLEQALIDCRVDLAVYHALDLPLELHPELPIVAISSREDVRDALVFPQG---KQQPDFS 120

Query: 124 I-VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
             +G +S R+Q QL    PD I   + G V  +L++LD GEY A++L  A L   GL+ R
Sbjct: 121 KPIGCTSRRQQVQLHRVFPDCITAPVGGTVAEQLARLDQGEYGALVLPAAQLGWFGLQQR 180

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
           +      E  +PA G  A+ ++ R        LL   +  ++   V  ER     LE   
Sbjct: 181 VGQLFCVEELVPAAGHAAIAVQARE--EFDAGLLECFHSWDSWDAVFCEREFARALEEE- 237

Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIR-GERRGAPQDAEQMGISLAEELL 295
             PI  +AE+    + +     A +   I R     G  +DA ++G  LA EL 
Sbjct: 238 PGPIAVHAEVKGETLSVVG-FYADEAEGIYRMSSMSGDRKDAGRLGFELAAELK 290


>UniRef50_B1ZV87 Porphobilinogen deaminase n=2 Tax=Opitutaceae RepID=B1ZV87_OPITP
          Length = 284

 Score =  247 bits (631), Expect = 4e-64,   Method: Composition-based stats.
 Identities = 94/260 (36%), Positives = 126/260 (48%), Gaps = 15/260 (5%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             L +ATR+SPLAL Q   V   L A   G+  EL+ +VT GD   +  L + GGKGLF 
Sbjct: 2   KKLILATRKSPLALRQTEMVAAHLEAR-LGVQTELLKLVTTGDRQTEWSLEQKGGKGLFT 60

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
            ELE AL    AD+AVHS KD+P +    L +     R D RD  V     +     A  
Sbjct: 61  SELENALRRGEADLAVHSTKDLPGDMAAELAVAGYLPRADARDVLVLRAGVA-----APK 115

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESR 182
            + T S RR+ Q+A+  P +    +RGNV TRL K+   G  D  +LA AGL RLG+ + 
Sbjct: 116 SLATGSPRRRLQIAKLYPGVTFTEIRGNVDTRLKKIGELGVADGTVLASAGLNRLGIGNW 175

Query: 183 IRAALP---PEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
                        +PAVGQGA+ ++CR  D+      A +    T   V  ERA    L 
Sbjct: 176 PGVEFHALGFNDMVPAVGQGAIAVQCRAADAA---RFAPVFDAATKRAVDVERAFQAALG 232

Query: 240 GGCQVPIGSYAELIDGEIWL 259
            GCQ   G++  +    +  
Sbjct: 233 VGCQTAFGAH--VAGDTLHF 250


>UniRef50_Q86ET2 Clone ZZD1450 mRNA sequence n=3 Tax=Schistosoma japonicum
           RepID=Q86ET2_SCHJA
          Length = 277

 Score =  236 bits (604), Expect = 6e-61,   Method: Composition-based stats.
 Identities = 83/207 (40%), Positives = 109/207 (52%), Gaps = 17/207 (8%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
             + +R+ +R+S LAL Q       L    P ++ E+V + T GD ILD PL+K+G K L
Sbjct: 6   SQHAVRVGSRRSNLALLQTEMAISLLKVQKPHIMFEVVEIATVGDEILDVPLSKIGDKSL 65

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFV---SNNYDSLDA 118
           F KELE +LL    D+ VHS+KDVP   P GL L  +  R  P D  +    N    L  
Sbjct: 66  FTKELEKSLLVGEVDLVVHSLKDVPSVLPTGLVLGCVFGRSSPEDVVLMAPHNRGMKLSD 125

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG--------------EY 164
           LP G+ VGTSS+RR   L  + P L   S+RGN+ TRL+KLD                 Y
Sbjct: 126 LPVGATVGTSSIRRVATLIRKYPHLKFISIRGNLNTRLAKLDTPSNLQKQCCTGNQSLSY 185

Query: 165 DAIILAVAGLKRLGLESRIRAALPPEI 191
           DA+ILA AG++R+G   RI   L    
Sbjct: 186 DALILAKAGVERMGWVDRIDQVLSDSF 212


>UniRef50_Q4E9D5 Porphobilinogen deaminase (Fragment) n=1 Tax=Wolbachia endosymbiont
           of Drosophila ananassae RepID=Q4E9D5_9RICK
          Length = 199

 Score =  235 bits (601), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 81/202 (40%), Positives = 121/202 (59%), Gaps = 6/202 (2%)

Query: 97  TICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRL 156
            + ER  P DAF+S+ ++SL++LP  + + TS++RR+ QL   RPDL I  LRGNV TRL
Sbjct: 1   CVLERLSPCDAFISHKHNSLESLPQQATIATSAIRRKVQLLNFRPDLNIVPLRGNVTTRL 60

Query: 157 SKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELL 216
               N  +D IILA AGL RL     I   LPP++ L AVGQGA+ I+CR +D +  +LL
Sbjct: 61  ---QNQSFDGIILAEAGLIRLEKHHLITEVLPPKVMLSAVGQGAICIQCRRNDVKIIDLL 117

Query: 217 AALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGE 275
             +N++ + + V +ER+    + G C  P+ + AE + +  ++LR ++   DG  I   E
Sbjct: 118 EKINNNMSFIGVKSERSFMKTVNGSCFTPLAALAEYVSENMLYLRCMLA--DGKNIYFTE 175

Query: 276 RRGAPQDAEQMGISLAEELLNN 297
           R    +DAE+MG+    EL + 
Sbjct: 176 RTSFIEDAEKMGMDAGLELKSK 197


>UniRef50_Q6MHU0 Hydroxymethylbilane synthase n=1 Tax=Bdellovibrio bacteriovorus
           RepID=Q6MHU0_BDEBA
          Length = 502

 Score =  232 bits (593), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 82/287 (28%), Positives = 124/287 (43%), Gaps = 31/287 (10%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LRI+ R+S LA  QA+ V D L   +P + ++     + GD  L  PL K+  KG+F ++
Sbjct: 3   LRISARKSDLARLQAYMVGDALKEKNPQIEIDYRFRESLGDKNLTDPLWKIPEKGVFTED 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN--YDSLDALPAGS 123
               LL +  D+ VHS KD+P E      +     R D RD  +     +D +       
Sbjct: 63  FFGELLRDETDLVVHSWKDLPTEHKSETVIAATLPRADQRDLLLVKKSHFDKIKTSKT-L 121

Query: 124 IVGTSSLRRQCQL----AERRP----DLIIRSLRGNVGTRLSKL-DNGEYDAIILAVAGL 174
            V +SS RR+  L     E  P    D+   S+RGN+ TR+ KL ++ E D +I+A A  
Sbjct: 122 KVFSSSPRREYNLTGFFKEHLPFGLQDVKFESVRGNMLTRVRKLIESPETDGLIVAKAAF 181

Query: 175 KRLG-----------------LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLA 217
            RL                          LP  ++  A  QGA+ +E        ++LL 
Sbjct: 182 DRLFSATLPEFLEGQQQLRQYFNELNWVVLPLSVNPNAAAQGALAVEVLKSRQDLQDLLQ 241

Query: 218 ALNHHETALRVTAERAMNTRLEGGCQVPIG--SYAELIDGEIWLRAL 262
           +++H +T      ER + +   GGC   IG    A        L+ L
Sbjct: 242 SIHHADTFHCSQKERDVLSSFGGGCHQKIGVAVLARPYGQITLLKGL 288


>UniRef50_B6YQR9 Hydroxymethylbilane synthase/uroporphyrin-III
           C-methyltransferase/uroporphyrinogen-III synthase n=1
           Tax=Candidatus Azobacteroides pseudotrichonymphae
           genomovar. CFP2 RepID=B6YQR9_AZOPC
          Length = 682

 Score =  225 bits (574), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 80/222 (36%), Positives = 119/222 (53%), Gaps = 18/222 (8%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG----- 60
           LR+ +R SPL+L Q   V     +  P +  +L+ + + GD      L  +         
Sbjct: 11  LRVISRNSPLSLLQVKEV----FSFFPNIDYQLITIESFGDKNKHVALFDISNVSSFFLE 66

Query: 61  ------LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD 114
                  F +EL+ AL+ N+ADIAVHS KD+P   P  L L  + +  D  D+ +S N  
Sbjct: 67  EESISDFFTRELDEALIYNKADIAVHSAKDLPYPLPYDLELFALFQAMDKSDSLISRNNL 126

Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174
           +L+ LP  + VGTSS +R+ +L + RPDL + S+RGN+  R++K+DNG  DA+I+A   L
Sbjct: 127 TLEQLPPRARVGTSSQKRKTELLKIRPDLEVVSIRGNIEERIAKMDNGFIDALIVATCAL 186

Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELL 216
            RLG+E+RI   LP E       QG + I  R +D   + L 
Sbjct: 187 IRLGMEARIACILPFETH---SLQGNLAIVGRKNDKNVKNLF 225


>UniRef50_B4UXX3 Porphobilinogen deaminase 2 (Fragment) n=1 Tax=Streptomyces sp. Mg1
           RepID=B4UXX3_9ACTO
          Length = 231

 Score =  225 bits (574), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 87/223 (39%), Positives = 117/223 (52%), Gaps = 8/223 (3%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             +R+ TR SP+AL Q     D   A +P +V+++V +V+ GD     PL+ +GGKG F 
Sbjct: 9   TTVRLGTRPSPMALEQTGRFADVFRARYPQVVLDIVEIVSEGDR-HRGPLSTIGGKGAFT 67

Query: 64  KELEVALLENRADIAVHSMKDVPVEFP--QGLGLVTICEREDPRDAFVSNNY---DSLDA 118
           +  +  LL+ R    +   KDVP       G+ +  +  RED RDA V        +L  
Sbjct: 68  RNADRYLLDGRVQATIACAKDVPGPHDRSPGIVIAAVLPREDTRDALVLPTGHPVTTLAE 127

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDA--IILAVAGLKR 176
           LP G+ VGTS+ RR   L    P L+   +RGN  +RL  LD G   A  +I A+AGL+R
Sbjct: 128 LPPGTRVGTSAPRRSALLKALHPTLVQVPIRGNADSRLRALDAGRLGADVMIAALAGLRR 187

Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAAL 219
           LG E R    L P + LPA G G V +E R DD  T  LLA L
Sbjct: 188 LGHEDRASEILDPAVWLPAAGAGTVIVEHRSDDPATGWLLAPL 230


>UniRef50_Q6MEK3 Putative Porphobilinogen deaminase n=2 Tax=Parachlamydiaceae
           RepID=Q6MEK3_PARUW
          Length = 233

 Score =  224 bits (571), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 3/218 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           + +  R SPL+  Q   +   L + +P +   +    T GD+   T L  +     F KE
Sbjct: 18  ISVGARSSPLSRAQVQEILKALRSFYPSIEFTISYFDTIGDLDQKTSLRDLDKTNFFTKE 77

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           ++ A+L+ +  I +HS KD+P   P GL L+ + +  D  D  V  + ++L  LP  S +
Sbjct: 78  IDEAILQKKCQIGIHSAKDLPDPIPDGLQLICLTKGVDCSDVLVLRDGETLQTLPPHSRI 137

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
            TSS+RR+  +   R D I   LRG +  RL+ L+  + D +++A A L RLGL    R 
Sbjct: 138 ATSSIRRENIVKLLRNDFIFLDLRGTIHQRLALLEKKQADGVVVAEAALIRLGLTHLNRI 197

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHE 223
            LP        GQG + I  R DD++ + L A L+  +
Sbjct: 198 RLP---GTTVEGQGQLAIIARKDDAKMQTLFACLDVRK 232


>UniRef50_A8I2X7 Porphobilinogen deaminase n=1 Tax=Chlamydomonas reinhardtii
           RepID=A8I2X7_CHLRE
          Length = 380

 Score =  216 bits (551), Expect = 8e-55,   Method: Composition-based stats.
 Identities = 91/234 (38%), Positives = 119/234 (50%), Gaps = 13/234 (5%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMA----SHPGLVVELVPMVTRGDVILDTPLAKVGG 58
              L IATR S LA  Q   V+  L+A        L +  + + +RGD      L  +G 
Sbjct: 60  QRPLVIATRPSKLAKEQTRQVQQLLLAAAQLKDEQLQLSTLELASRGDTTQGVSLRSLGS 119

Query: 59  KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118
            G F +EL+ A+L   AD++VHS+KD P     GL L     R DPRD  ++    SL  
Sbjct: 120 -GAFTEELDQAVLSGAADMSVHSLKDCPAALAPGLLLAACLPRADPRDVLIAPEATSLGE 178

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178
           L  GS VGTSS RR  Q+    P L +  LRGNV +RL ++ + +  A +LA AGLKRLG
Sbjct: 179 LVPGSRVGTSSSRRAAQIKHSFPHLQVVQLRGNVDSRLGRIRSRDIGATVLAAAGLKRLG 238

Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232
           + +                 GAVG+ CR DD     LL A++H  TAL V AER
Sbjct: 239 VMNSDEGD--------TTATGAVGVVCRADDEWVVGLLDAISHRGTALEVAAER 284


>UniRef50_Q6Q923 Predicted porphobilinogen deaminase n=2 Tax=environmental samples
           RepID=Q6Q923_9GAMM
          Length = 291

 Score =  209 bits (532), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 83/251 (33%), Positives = 117/251 (46%), Gaps = 15/251 (5%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            ++IA+R S LAL Q      K   S      +++ + T GD I       +  K  FV 
Sbjct: 2   TIKIASRSSKLALAQVEEFVKKFGIS----DYKIIKVKTEGD-IKSANGETLFDKAHFVS 56

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           +++  LL   ADIAVHS KD P     GL L      +  +D  +    D  ++      
Sbjct: 57  DVQKCLLNGEADIAVHSAKDTPAGETTGL-LRYFLPSQSNQDVLIFREEDKFNS---EMK 112

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GTSSLRRQ Q       + I +L GNV TRL KL  GEYD IILA AGL RL L + ++
Sbjct: 113 LGTSSLRRQLQAKHHLNAINIVNLSGNVDTRLEKLSQGEYDCIILAKAGLARLKLLNELQ 172

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSR--TRELLAALNHHETAL--RVTAERAMNTRLEG 240
             +    +  A GQG + IE   D S      LL ++   +  L   ++ ER++   +  
Sbjct: 173 YEVMDWST--ASGQGFLCIEVLNDPSADIYNFLLKSIREIDLNLGKNISTERSILEAINA 230

Query: 241 GCQVPIGSYAE 251
           GC   I    +
Sbjct: 231 GCNSAISIQTQ 241


>UniRef50_Q9PK95 Probable porphobilinogen deaminase n=13 Tax=Chlamydiaceae
           RepID=HEM3_CHLMU
          Length = 242

 Score =  201 bits (511), Expect = 4e-50,   Method: Composition-based stats.
 Identities = 69/197 (35%), Positives = 105/197 (53%), Gaps = 3/197 (1%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            LR+A+R+SPLA+ QAH    +L    P L  +++   T+GD+   TPL  V   G F  
Sbjct: 20  PLRLASRKSPLAVLQAHECLRRLQTFFPRLWGQVITETTQGDLDQHTPLHSVENTGFFTD 79

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           +++  +   + D+A+HS KD+P E P+   +  I    DPRD  V      L   P+   
Sbjct: 80  DIDFLVQSGKCDLAIHSAKDLP-EKPKARVI-AITASIDPRDILVFQEKYLLQPFPSRLR 137

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +G SS RR+  ++   P  +I  +RG + TRL+ LD  ++DAI++A A + RLGL     
Sbjct: 138 IGCSSDRRRALISSLYPSAVITDIRGTIQTRLALLDQQKFDAIVMANAAVSRLGLRLPCT 197

Query: 185 AALPPEISLPAVGQGAV 201
             LPP    P  G+ A+
Sbjct: 198 VVLPPPYH-PFQGRLAI 213


>UniRef50_D0RNS6 Putative porphobilinogen deaminase (Pbg)(Hydroxymethylbilane
           synthase) (Hmbs) (Pre-uroporphyrinogen synthase) n=1
           Tax=alpha proteobacterium HIMB114 RepID=D0RNS6_9RICK
          Length = 492

 Score =  198 bits (504), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 79/281 (28%), Positives = 120/281 (42%), Gaps = 28/281 (9%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   L I +R S LA  Q   VK +L      + +      T+GD        K  G G+
Sbjct: 1   MSLSLIIGSRASFLAKIQTFIVKQELKKKIKNIKITTKYHSTKGDKNQGHMPWKNLGYGI 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F   L   L+    +  VHS KD+PV   +      +  R+DPRD  +            
Sbjct: 61  FTTSLTNELINKNFNCVVHSYKDLPVL--KSKTDYYVITRDDPRDVLLVKKKCLNK---K 115

Query: 122 GSIVGTSSLRRQCQLAERR-----PDLIIRSLRGNVGTRLSK-LDNGEYDAIILAVAGLK 175
             IVGTSS RR+  + + +      D+  +++RGNV TRL K +   +YDA+ +A A + 
Sbjct: 116 KFIVGTSSPRRKSSVKDLKDLTGIKDIKTKTIRGNVTTRLLKVISKNQYDAVFMAKAAID 175

Query: 176 R----------------LGLESRIR-AALPPEISLPAVGQGAVGIECRLDDSRTRELLAA 218
           R                L L  + +   LP  I   A  QGA+ +E   +D +T+  L  
Sbjct: 176 RIFKYGNKVDKVETKKFLNLFKKFKPFILPLSIFPTAASQGAIAVEYLKNDKKTKSTLNK 235

Query: 219 LNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWL 259
           +N  +T      ER++  +  GGC + IG   E I    +L
Sbjct: 236 INCKKTLSICNQERSLLKKYGGGCGLDIGITIEEIKNNNFL 276


>UniRef50_C5LJF7 Porphobilinogen deaminase, putative n=5 Tax=Perkinsus marinus ATCC
           50983 RepID=C5LJF7_9ALVE
          Length = 556

 Score =  196 bits (499), Expect = 9e-49,   Method: Composition-based stats.
 Identities = 79/284 (27%), Positives = 118/284 (41%), Gaps = 40/284 (14%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62
            +VL I +R+S LA  Q   + D L     G+ VE       GD  L  PL K+   G+F
Sbjct: 7   PSVLHIGSRRSDLARLQTLMIADLLQDE-MGVKVECHYREAPGDTNLKDPLWKMPETGVF 65

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122
              L   L+    D+ VHS KD+P+    G  +V    R DPRD  +    D+++ + + 
Sbjct: 66  TSFLRDGLMNGAFDLVVHSWKDLPLAEESGTTVVATLPRADPRDLLLIRR-DAIEEMTSE 124

Query: 123 S---IVGTSSLRRQCQLAERRP-------DLIIRSLRGNVGTRLSKLDNGEY-------- 164
               IV +SS RRQ  L             +  R +RGN+ TR+ KL +           
Sbjct: 125 GGKLIVLSSSPRRQFNLTPFLESVVPGVTSVQFRDVRGNIQTRMKKLMDPTIHDESLGCR 184

Query: 165 -DAIILAVAGLKRL----------------GLESRIRAALPPEISLP-AVGQGAVGIECR 206
              +++A A + R                 G  S  R  + P  + P A  QGA+GIE  
Sbjct: 185 PHGLVVAKAAVDRFIRSTREEFKESRQLVQGYISECRCMVLPLSANPTAAAQGALGIEVS 244

Query: 207 L--DDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGS 248
              +    R+++ +LN   T    + E+ +     GGC   IG 
Sbjct: 245 TAPEKEHVRKIVRSLNDRSTFDAASKEKELLNSYGGGCHQKIGC 288


>UniRef50_Q9HMY5 Probable porphobilinogen deaminase n=2 Tax=Halobacterium salinarum
           RepID=HEM3_HALSA
          Length = 396

 Score =  192 bits (489), Expect = 1e-47,   Method: Composition-based stats.
 Identities = 72/159 (45%), Positives = 96/159 (60%), Gaps = 2/159 (1%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M    +R+ATR S LAL QA  V D L        VELV + T GD + D  ++ +G  G
Sbjct: 1   MSSQQIRLATRGSDLALRQAGEVVDTLEDRRHD--VELVEVETEGDRVTDALISDLGKTG 58

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
            FV+ L+  ++E   D AVHSMKDVP E P+ L +  +  RE+P D  V+ +   L+ LP
Sbjct: 59  AFVRALDQEVMEGTVDAAVHSMKDVPTEVPEDLVVAAVPHRENPADVLVTPDGTDLEDLP 118

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL 159
           AGS+VGT+SLRR  Q+   RP L +  +RGNVGTR+ KL
Sbjct: 119 AGSVVGTASLRRGAQVQAHRPGLDVEPIRGNVGTRVEKL 157



 Score =  135 bits (341), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 1/146 (0%)

Query: 161 NGEYDAIILAVAGLKRLGLESRIR-AALPPEISLPAVGQGAVGIECRLDDSRTRELLAAL 219
           + EYDA+++A  GL+R GL   +    L     +PA GQGA+ +  R D      L  AL
Sbjct: 246 DTEYDALVMARVGLERTGLLHHVGIEELSTGTHVPATGQGALCVTARRDSDVVDTLRDAL 305

Query: 220 NHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGA 279
            H  T + VTAER +   L GGC  PIG +A +    I     V + DGS+ +   R   
Sbjct: 306 EHVRTRVEVTAERVVLEELGGGCIAPIGVHALVQGDTIRTAVQVFSQDGSEQVGETRELD 365

Query: 280 PQDAEQMGISLAEELLNNGAREILAE 305
            +        LA +L + GA +++ +
Sbjct: 366 AEQYATDARELAADLRDRGAADLIED 391


>UniRef50_Q18ES3 Hydroxymethylbilane synthase (Porphobilinogen deaminase) n=9
           Tax=Halobacteriaceae RepID=Q18ES3_HALWD
          Length = 394

 Score =  181 bits (459), Expect = 4e-44,   Method: Composition-based stats.
 Identities = 66/157 (42%), Positives = 95/157 (60%), Gaps = 4/157 (2%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            L +ATR S LAL QA  V++ L        V+L+ + TRGD I D  + ++G  G FV+
Sbjct: 10  TLTLATRGSDLALKQATSVQEALTDER--YEVDLIEVETRGDQIQDELIHQLGKTGAFVR 67

Query: 65  ELEVALLE--NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122
            L+  +L+    AD AVHSMKD+P + P  L +  I +R  P D  ++ +   L  LP+G
Sbjct: 68  ALDKKVLDPTAEADAAVHSMKDMPTDSPDDLVVAGIPQRAPPGDLLITTDGQRLSDLPSG 127

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL 159
           + +GTSSLRRQ QL ++R D+ +  LRGN+ TR+ KL
Sbjct: 128 ATIGTSSLRRQAQLLDQRTDITVEPLRGNIDTRIEKL 164



 Score =  139 bits (350), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 51/150 (34%), Positives = 75/150 (50%), Gaps = 1/150 (0%)

Query: 156 LSKLDNGEYDAIILAVAGLKRLGLESRIRAAL-PPEISLPAVGQGAVGIECRLDDSRTRE 214
           L +    EYDAI+LA AGL+R GL   I          +PA GQGA+ I  + + + T +
Sbjct: 228 LERSVETEYDAIVLAEAGLQRSGLIHHIEYVQLDTTTFVPAPGQGAIAITTQGEANATAQ 287

Query: 215 LLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRG 274
           +  A++H  T +  T ER +   L GGC  PIG +A L    + + A V A DG++ + G
Sbjct: 288 IREAIDHPRTRVETTVERTVLAELGGGCIAPIGVHATLQGEYVHVAAQVFASDGTETVDG 347

Query: 275 ERRGAPQDAEQMGISLAEELLNNGAREILA 304
            R              A +L + GA E++A
Sbjct: 348 SRNLPVDAHADAAAQFANKLADRGADELIA 377


>UniRef50_B0KCR7 Porphobilinogen deaminase n=3 Tax=Thermoanaerobacter
           RepID=B0KCR7_THEP3
          Length = 168

 Score =  159 bits (402), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 48/164 (29%), Positives = 82/164 (50%), Gaps = 7/164 (4%)

Query: 136 LAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPA 195
           +     D+ I  +RGNV TRL K++    D I+L+ AGL RLGLES I    PP++ +PA
Sbjct: 4   IQALMSDIQIVPIRGNVRTRLKKMEELNLDGIVLSAAGLHRLGLESIITEYFPPDVVVPA 63

Query: 196 VGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAEL-- 252
             QG + +E     D+  +E  + +    T    + ER +       C+ P G+YA+   
Sbjct: 64  PCQGILAVEIAESFDNIFQEFYSYIVDRRTFFEASVERELLKAFGVNCRQPFGAYAQYRK 123

Query: 253 --IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
              + +I ++ +    D  ++++ E  G  ++ ++M   L EE 
Sbjct: 124 EKDEEKINIKVVYQKED--KLLKSEVTGLIEETDKMIEKLIEEF 165


>UniRef50_UPI000155526F PREDICTED: similar to hydroxymethylbilane synthase n=1
           Tax=Ornithorhynchus anatinus RepID=UPI000155526F
          Length = 218

 Score =  158 bits (401), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 60/130 (46%), Positives = 78/130 (60%), Gaps = 9/130 (6%)

Query: 75  ADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALPAGSIVGTSSLR 131
            D+ VHS+KD+P   P G  +  +C+RE P DA V +      +L  LP  S+VGTSSLR
Sbjct: 90  VDLVVHSLKDLPTVLPPGFTIGAVCKRESPYDAVVFHPKHVGKTLATLPEKSVVGTSSLR 149

Query: 132 RQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESRIRAALPPE 190
           R  QL  + P L  +S+RGN+ TRL KLD   E+ AIILA AGL+RLG +SR+       
Sbjct: 150 RAAQLQRKFPHLEFKSIRGNLNTRLRKLDELQEFSAIILAAAGLQRLGWQSRLGQVR--- 206

Query: 191 ISLPAV-GQG 199
              PA  G+G
Sbjct: 207 -VAPAPRGRG 215


>UniRef50_C0DZX9 Putative uncharacterized protein n=1 Tax=Corynebacterium
           matruchotii ATCC 33806 RepID=C0DZX9_9CORY
          Length = 152

 Score =  156 bits (394), Expect = 1e-36,   Method: Composition-based stats.
 Identities = 54/150 (36%), Positives = 80/150 (53%), Gaps = 1/150 (0%)

Query: 156 LSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTREL 215
           ++K+ +GE DA++LA AGL R+           P   LPA  QGA+ +ECR DD+ T   
Sbjct: 1   MAKVHDGELDAVVLAYAGLSRVHRADEATEVFDPLEFLPAPAQGALAVECRADDADTIAA 60

Query: 216 LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRG 274
           +  +   +       ER +  RLE GC  P+ +YA +  D  + L A V A DGS  +R 
Sbjct: 61  ITTIADSKAYACAHTERVVLARLEAGCTAPVAAYATVAADNIMTLHAAVIAMDGSATLRA 120

Query: 275 ERRGAPQDAEQMGISLAEELLNNGAREILA 304
              G    AE +G+++A  LL++GA  +LA
Sbjct: 121 TAAGPIDTAENLGMTVARALLDDGASSLLA 150


>UniRef50_UPI0001B4213A porphobilinogen deaminase n=1 Tax=Listeria monocytogenes LO28
           RepID=UPI0001B4213A
          Length = 128

 Score =  144 bits (365), Expect = 3e-33,   Method: Composition-based stats.
 Identities = 52/124 (41%), Positives = 79/124 (63%), Gaps = 2/124 (1%)

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             +PPE+ LPAVGQGA+ IECR  D + R++L +++H ET + V AER    +L GGC++
Sbjct: 6   EDIPPEVCLPAVGQGALAIECRESDQQIRDMLTSIHHEETGICVEAERVFLKKLNGGCEI 65

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304
           PI  +A   +  +  + LVG  DGS I+  E+ GA  +  ++G  +AE+LL+ GA  I+ 
Sbjct: 66  PIAGFATRANEFVQFKGLVGNADGSIILESEQVGA--NPSEIGNKVAEDLLSEGADTIIK 123

Query: 305 EVYN 308
           E+ N
Sbjct: 124 ELRN 127


>UniRef50_A8CBG6 Porphobilinogen deaminase n=3 Tax=Toxoplasma gondii
           RepID=A8CBG6_TOXGO
          Length = 747

 Score =  142 bits (358), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 55/163 (33%), Positives = 73/163 (44%), Gaps = 33/163 (20%)

Query: 124 IVGTSSLRRQCQLAERRP--DLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL-- 179
            +GT SLRRQ  L    P     +  LRGNV TR+S+++ G  DA +LA AGLKRL L  
Sbjct: 444 RIGTCSLRRQALLYALLPPSSFQLMGLRGNVQTRMSRIEKGTLDATLLAAAGLKRLNLLS 503

Query: 180 ---------------------ESRIRAAL--------PPEISLPAVGQGAVGIECRLDDS 210
                                 SR             P ++ +PAV QG +G++CR  D+
Sbjct: 504 AMLAPSPSATPSPCPAPSPNETSRGTEPGGCVEAVLLPADVFVPAVCQGIIGVQCRSADT 563

Query: 211 RTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELI 253
               LL  LN   +  +   ERA    L+G C+ PI   AE  
Sbjct: 564 GILSLLRELNSPSSRGQALCERAFLRALDGSCRTPIAGIAEWR 606



 Score =  117 bits (294), Expect = 5e-25,   Method: Composition-based stats.
 Identities = 41/81 (50%), Positives = 53/81 (65%)

Query: 35  VVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLG 94
            + +VPM T GD  L  PLA+VGGKGLF KEL++ALL  + D+ VHS+KDVP E P+G  
Sbjct: 268 ELRIVPMQTTGDKELHLPLAQVGGKGLFTKELDLALLHGQVDVVVHSLKDVPTELPEGTE 327

Query: 95  LVTICEREDPRDAFVSNNYDS 115
           +     REDPRDA + +    
Sbjct: 328 IGAYLPREDPRDALIFSRKPR 348



 Score = 49.7 bits (118), Expect = 1e-04,   Method: Composition-based stats.
 Identities = 18/67 (26%), Positives = 32/67 (47%), Gaps = 5/67 (7%)

Query: 247 GSYAELIDGEI-WLRALVGAPDGSQIIRGERRG----APQDAEQMGISLAEELLNNGARE 301
           G  A     ++     ++  PDG Q+ R ER       P++AE +G ++AEE+      +
Sbjct: 669 GVLATPDGKQLLRFCGVLATPDGKQLFREERTVRGVRTPEEAEALGRAVAEEIKKAAGAD 728

Query: 302 ILAEVYN 308
            LA++  
Sbjct: 729 RLAQIKK 735



 Score = 41.6 bits (97), Expect = 0.036,   Method: Composition-based stats.
 Identities = 12/31 (38%), Positives = 15/31 (48%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPG 33
              LR+ +R SPLAL QA     +L    P 
Sbjct: 160 KTPLRVGSRASPLALAQARQFVYRLALRFPD 190


>UniRef50_UPI0001742E92 Porphobilinogen deaminase n=1 Tax=candidate division TM7
           single-cell isolate TM7a RepID=UPI0001742E92
          Length = 119

 Score =  129 bits (325), Expect = 1e-28,   Method: Composition-based stats.
 Identities = 32/115 (27%), Positives = 60/115 (52%), Gaps = 2/115 (1%)

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
           +      +  +PA GQG + I+CR +D++ R LL  +N  E  +   AER  +   +GGC
Sbjct: 1   MSEYFDTDFFMPAPGQGILCIQCRENDNKIRHLLEIINDDEVTMMCEAEREFSKIFDGGC 60

Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
             PIG  + +    + L+ +    +GS++++ E  G  ++ +++   LAEE+   
Sbjct: 61  HTPIGCSSVIEGDTLKLKGM-FNDNGSRMLK-EVEGNKENPKEIAQKLAEEIKKE 113


>UniRef50_Q1HRH6 Hydroxymethylbilane synthase-like protein n=1 Tax=Aedes aegypti
           RepID=Q1HRH6_AEDAE
          Length = 349

 Score =  118 bits (296), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 34/111 (30%), Positives = 52/111 (46%), Gaps = 6/111 (5%)

Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236
           +G E RI   + P   L AVGQGA+ +ECR +D     +L+ L H ET  ++  ER+   
Sbjct: 1   MGWEKRIDQVIEPSEILYAVGQGALAVECRSNDEYILNMLSKLCHLETQCKILVERSFLK 60

Query: 237 RLEGGCQVPIGSYAEL------IDGEIWLRALVGAPDGSQIIRGERRGAPQ 281
            L GGC  P+     L          + ++  V + DG   IR +   + +
Sbjct: 61  TLGGGCSAPVAVCTSLKRKHDSKSNYLNIQGAVWSLDGKTEIRADDGCSVE 111


>UniRef50_Q401C3 Hydroxymethylbilane synthase (Fragment) n=7 Tax=Coelomata
           RepID=Q401C3_CAPHI
          Length = 109

 Score =  117 bits (294), Expect = 6e-25,   Method: Composition-based stats.
 Identities = 41/81 (50%), Positives = 54/81 (66%), Gaps = 1/81 (1%)

Query: 113 YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAV 171
             +L+ LP  S+VGTSSLRR  QL  + P L  R++RGN+ TRL KLD   E+ AIILA 
Sbjct: 29  GKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRNIRGNLNTRLRKLDELQEFSAIILAA 88

Query: 172 AGLKRLGLESRIRAALPPEIS 192
           AGL+R+G ++R+   L PE  
Sbjct: 89  AGLQRMGWQNRVGQILHPEEC 109


>UniRef50_UPI0001698669 porphobilinogen deaminase n=1 Tax=Endoriftia persephone
           'Hot96_1+Hot96_2' RepID=UPI0001698669
          Length = 136

 Score =  112 bits (280), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 64/133 (48%), Positives = 79/133 (59%), Gaps = 11/133 (8%)

Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231
           AGLKRLG E RI A + PE SLPA+GQGA+GIECR DD++   L+A L+H +TA  V AE
Sbjct: 8   AGLKRLGFEQRITAFIAPEQSLPAIGQGAIGIECRSDDAQVNALIAPLHHVDTAACVHAE 67

Query: 232 RAMNTRLEGG-----CQV-PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQ 285
           RAMN RL GG     C++   G  A       W R+ V      +   GE  G P +AE 
Sbjct: 68  RAMNNRLMGGSPCADCRLRDAGVPATSGCVVWWARSTVA-----RSCVGEAEGTPDEAES 122

Query: 286 MGISLAEELLNNG 298
           +G+ LAE LL  G
Sbjct: 123 LGVGLAERLLELG 135


>UniRef50_B8N6H4 Putative uncharacterized protein n=1 Tax=Aspergillus flavus
          NRRL3357 RepID=B8N6H4_ASPFN
          Length = 90

 Score =  100 bits (250), Expect = 6e-20,   Method: Composition-based stats.
 Identities = 30/79 (37%), Positives = 40/79 (50%)

Query: 5  VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           LRI TR+S LA+ QA  +++ L    PG   E+  + T GD    T L   G K L+  
Sbjct: 10 PLRIGTRRSNLAMVQAEGIRNCLQKIAPGRSFEIEALRTLGDRDQLTALYNFGAKSLWTT 69

Query: 65 ELEVALLENRADIAVHSMK 83
          ELE  L     D+ VH +K
Sbjct: 70 ELEEKLNAGELDVIVHCLK 88


>UniRef50_UPI0000D9FBB5 PREDICTED: similar to lethal (3) 02640 CG9165-PA n=1 Tax=Macaca
           mulatta RepID=UPI0000D9FBB5
          Length = 105

 Score = 95.2 bits (236), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 34/111 (30%), Positives = 45/111 (40%), Gaps = 17/111 (15%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
            +  LRI +R+S LA  Q   V D+L     G  V LV M                  G+
Sbjct: 5   SNATLRIGSRRSDLARLQTLMVADRLEE--MGYKVVLVGM---------------PETGV 47

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN 112
           F   L   LL+   D+ VHS KD+P+    G  +     R DPRD  +   
Sbjct: 48  FTTFLRQKLLDGSVDLVVHSWKDLPLAEEAGTTVAATLPRADPRDLIIIRK 98


>UniRef50_UPI0001C35DE1 porphobilinogen deaminase n=1 Tax=Clostridium hathewayi DSM 13479
           RepID=UPI0001C35DE1
          Length = 121

 Score = 79.7 bits (196), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 25/112 (22%), Positives = 47/112 (41%), Gaps = 3/112 (2%)

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
                 E  +PA GQG + +E R++D R  E+   +   +    +  ER +   L+ GC 
Sbjct: 13  FHYFACEAFIPAGGQGILAVEGRIED-RICEMAVRIQDEDAKTCLMLERKILKLLDAGCH 71

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295
            P+G Y+ +   EI +  +  +    +  R    G   + + +    A+ L 
Sbjct: 72  EPVGVYSRIRGEEIEVFGI--SRRDRETKRVYLTGGIGELDLLAERAAKGLR 121


>UniRef50_C5U771 Porphobilinogen deaminase n=1 Tax=Methanocaldococcus infernus ME
           RepID=C5U771_9EURY
          Length = 89

 Score = 72.0 bits (176), Expect = 3e-11,   Method: Composition-based stats.
 Identities = 26/85 (30%), Positives = 39/85 (45%), Gaps = 7/85 (8%)

Query: 217 AALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER 276
             +N  +T L  TAER     L  GC VP G++A+     + L+  V   D  ++I+ E 
Sbjct: 2   EKINDKKTFLETTAERKALNELGCGCHVPFGAFAKYEGKRLMLKVAVANKD--RVIKKES 59

Query: 277 RGA-----PQDAEQMGISLAEELLN 296
                    + AE++G SL  EL  
Sbjct: 60  SICCEVDEIEKAEKLGESLGRELRR 84


>UniRef50_C5G109 Porphobilinogen deaminase n=1 Tax=Microsporum canis CBS 113480
           RepID=C5G109_NANOT
          Length = 282

 Score = 71.7 bits (175), Expect = 3e-11,   Method: Composition-based stats.
 Identities = 52/233 (22%), Positives = 80/233 (34%), Gaps = 48/233 (20%)

Query: 84  DVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDL 143
           DV  + P       I  +           Y SL  LP G+I+ TS +R   QL    P L
Sbjct: 93  DVSTKLPDSCDPAAIPVKA-------GLPYTSLQTLPEGAIIATSLVRPSAQLRRLFPTL 145

Query: 144 IIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGI 203
              ++R            G  +++ +  A    LG         P         QG    
Sbjct: 146 RFANVR------------GNVESLTIPQA----LGTVGSSTRGRPRARRR--RHQGY--- 184

Query: 204 ECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALV 263
                 + + + L AL    + L           L  GC  PIG   E     + +RA+V
Sbjct: 185 ----SSAGSADRLLAL---PSVLMC--------ALRSGCNAPIGIETEWTATHLSIRAIV 229

Query: 264 GAPDGSQIIRGERRG---APQDAEQMGISLAEELLNNGAREILAEVYNGDAPA 313
            + D SQ +            +++  G +LA  L   G   IL ++ N + P+
Sbjct: 230 VSLDISQSVEDAIDAMMHTKDESDAPGQALA-RLFGAGVAPILIDI-NRNQPS 280


>UniRef50_C4Z1K5 Putative uncharacterized protein n=1 Tax=Eubacterium eligens ATCC
           27750 RepID=C4Z1K5_EUBE2
          Length = 287

 Score = 63.6 bits (154), Expect = 8e-09,   Method: Composition-based stats.
 Identities = 47/228 (20%), Positives = 91/228 (39%), Gaps = 34/228 (14%)

Query: 55  KVGGKGLFVKELEVALLENRADIAVHSMKDVPV---------EFPQGLGLVTICEREDPR 105
           ++GG  ++   LE AL+++  D+    + D+ +         +   G+ +  + +R DPR
Sbjct: 42  EIGGSDIY-PALE-ALIDDNIDMV---LVDMRMLVEMEKSGQQLDDGIVISGVIKRRDPR 96

Query: 106 DAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYD 165
              +         +   ++V T S      + E   ++    +  N+   +SKLD+ E D
Sbjct: 97  YVMIRRRGT--KDVVENAVVVTDSDENAAVICEMYDNVECV-VENNIKDCMSKLDSEECD 153

Query: 166 AIILAV---AGLKRL--GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALN 220
           A + A      + RL  GL+ +    +     +P  GQG   I      S  + +   ++
Sbjct: 154 A-VFAFYDDIRIARLYNGLKYKYT-LMDFSDCVPPHGQGIYCILTNGKRSVIKHMFD-VS 210

Query: 221 HHETALRVTAERAMNTRLEG-----GCQVPIGSYAELIDGEIWLRALV 263
           H  TA+    E  +  RL        C     +Y ++   +I + A V
Sbjct: 211 HRTTAMSFDIEEDIIRRLLMNDYVKSCN----AYVKISGDKIEVYADV 254


>UniRef50_Q4EB45 Porphobilinogen deaminase n=1 Tax=Wolbachia endosymbiont of
          Drosophila ananassae RepID=Q4EB45_9RICK
          Length = 62

 Score = 62.0 bits (150), Expect = 2e-08,   Method: Composition-based stats.
 Identities = 20/50 (40%), Positives = 30/50 (60%)

Query: 6  LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAK 55
          ++I TR S LA+ QA   K KL+ S P L +E+V + + GD   +  LA+
Sbjct: 13 VKIGTRGSKLAVVQALEAKQKLLDSFPNLSIEIVKIKSSGDKYANANLAE 62


>UniRef50_B5XH53 Porphobilinogen deaminase n=1 Tax=Salmo salar RepID=B5XH53_SALSA
          Length = 55

 Score = 58.6 bits (141), Expect = 3e-07,   Method: Composition-based stats.
 Identities = 15/39 (38%), Positives = 22/39 (56%)

Query: 3  DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPM 41
            V+RI TR S LA  Q   V +KL   +P + +E+V +
Sbjct: 16 SRVIRIGTRNSQLARIQTDSVAEKLKGLYPDVHIEIVGI 54


>UniRef50_C2BR76 Putative uncharacterized protein (Fragment) n=1 Tax=Corynebacterium
           pseudogenitalium ATCC 33035 RepID=C2BR76_9CORY
          Length = 62

 Score = 58.2 bits (140), Expect = 4e-07,   Method: Composition-based stats.
 Identities = 16/62 (25%), Positives = 32/62 (51%)

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
            P+ + +     ++ +R  V A DGS+ +     G+  +A  +G  +++EL   GA E+L
Sbjct: 1   APVAATSRWDGDQLTVRGGVFALDGSRQLTATASGSAAEAADLGARISDELFAGGAAELL 60

Query: 304 AE 305
            +
Sbjct: 61  GK 62


>UniRef50_UPI0000D537E6 hypothetical protein P700755_22735 n=1 Tax=Psychroflexus torquis
           ATCC 700755 RepID=UPI0000D537E6
          Length = 356

 Score = 45.5 bits (107), Expect = 0.002,   Method: Composition-based stats.
 Identities = 46/234 (19%), Positives = 82/234 (35%), Gaps = 38/234 (16%)

Query: 68  VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127
            +L +   D+   S  D   +  +GL +  +  R++P    V+N+    + L  G+ +  
Sbjct: 49  QSLRDGAGDLVAMSAFDWQQQDVEGLIIAGLLTRKEPTWVLVANDKP--EYLKQGAYILC 106

Query: 128 SS--LRRQCQLAERRPDLIIRSL-----RGNVGTRLSKLDN-------------GEYDAI 167
               LRR  Q+   R DL + ++     R N    +S+LD              G  D  
Sbjct: 107 DHELLRR--QMMRLRGDLTLETMEEMGKRLNAAATISELDEEDIWPWVEGLLKNGNIDGF 164

Query: 168 ILAVA--GLKR-------LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAA 218
           I+  A     R       LGL+         E  +P    G   +  R    +    +  
Sbjct: 165 IVPRAIHASHRMKSRRHTLGLQRDNSE-SNRERFIPPPLHGFTMLVGRNGFPKAS--IQD 221

Query: 219 LNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQII 272
           +      L    E A+   LE   +  +G++ E       L+    + DG + +
Sbjct: 222 MVDQSAELAYRLEAAILESLEPSLRPIVGAFVEQRKIATILKK--ASEDGDEAL 273


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_B7LU53 Porphobilinogen deaminase n=87 Tax=cellular orga...   447   e-124
UniRef50_B5FN93 Porphobilinogen deaminase n=168 Tax=cellular org...   440   e-122
UniRef50_Q3ACT3 Porphobilinogen deaminase n=2 Tax=Bacteria RepID...   436   e-121
UniRef50_C0QU69 Porphobilinogen deaminase n=4 Tax=Bacteria RepID...   435   e-120
UniRef50_B5YJZ4 Porphobilinogen deaminase n=2 Tax=Bacteria RepID...   429   e-119
UniRef50_C0Q9U2 HemC n=2 Tax=Bacteria RepID=C0Q9U2_DESAH              428   e-118
UniRef50_Q8YVU6 Porphobilinogen deaminase n=50 Tax=cellular orga...   423   e-117
UniRef50_D1BNZ5 Porphobilinogen deaminase n=3 Tax=Veillonella Re...   422   e-117
UniRef50_Q8DIE4 Porphobilinogen deaminase n=11 Tax=cellular orga...   419   e-116
UniRef50_Q0I178 Porphobilinogen deaminase n=45 Tax=Bacteria RepI...   415   e-115
UniRef50_Q65GK1 Porphobilinogen deaminase n=98 Tax=Bacillales Re...   414   e-114
UniRef50_A1AUE7 Porphobilinogen deaminase n=44 Tax=Bacteria RepI...   413   e-114
UniRef50_B5EBG8 Porphobilinogen deaminase n=166 Tax=Bacteria Rep...   411   e-113
UniRef50_A6TJD5 Porphobilinogen deaminase n=2 Tax=Firmicutes Rep...   410   e-113
UniRef50_C9KL85 Hydroxymethylbilane synthase n=1 Tax=Mitsuokella...   409   e-113
UniRef50_Q31PM2 Porphobilinogen deaminase n=8 Tax=cellular organ...   406   e-112
UniRef50_C6HUG2 Porphobilinogen deaminase n=1 Tax=Leptospirillum...   402   e-110
UniRef50_Q5ZRY6 Porphobilinogen deaminase n=6 Tax=Legionella Rep...   399   e-110
UniRef50_Q2RJ26 Porphobilinogen deaminase n=5 Tax=Clostridia Rep...   397   e-109
UniRef50_P08397 Porphobilinogen deaminase n=59 Tax=Chordata RepI...   394   e-108
UniRef50_B2A1G7 Porphobilinogen deaminase n=1 Tax=Natranaerobius...   393   e-108
UniRef50_Q30Y29 Porphobilinogen deaminase n=13 Tax=Bacteria RepI...   393   e-108
UniRef50_Q4L709 Porphobilinogen deaminase n=88 Tax=Bacillales Re...   391   e-107
UniRef50_B3QWI1 Porphobilinogen deaminase n=12 Tax=Chlorobiaceae...   390   e-107
UniRef50_C9R7U0 Porphobilinogen deaminase n=1 Tax=Ammonifex dege...   390   e-107
UniRef50_B3E2H7 Porphobilinogen deaminase n=3 Tax=Proteobacteria...   389   e-107
UniRef50_Q54P93 Porphobilinogen deaminase n=1 Tax=Dictyostelium ...   388   e-106
UniRef50_Q2LQU2 Porphobilinogen deaminase n=1 Tax=Syntrophus aci...   385   e-105
UniRef50_A8PKX6 Porphobilinogen deaminase n=2 Tax=Gammaproteobac...   384   e-105
UniRef50_A7NKU8 Porphobilinogen deaminase n=5 Tax=Bacteria RepID...   382   e-105
UniRef50_A3ETN3 Porphobilinogen deaminase n=2 Tax=Leptospirillum...   382   e-105
UniRef50_Q1J288 Porphobilinogen deaminase n=5 Tax=Deinococci Rep...   382   e-104
UniRef50_Q180R9 Porphobilinogen deaminase n=11 Tax=Bacteria RepI...   380   e-104
UniRef50_A6WXJ2 Porphobilinogen deaminase n=56 Tax=cellular orga...   380   e-104
UniRef50_B6FXV9 Putative uncharacterized protein n=1 Tax=Clostri...   379   e-104
UniRef50_B2S842 Porphobilinogen deaminase n=38 Tax=Rhizobiales R...   377   e-103
UniRef50_A7GYU4 Porphobilinogen deaminase n=34 Tax=Campylobacter...   377   e-103
UniRef50_O94048 Porphobilinogen deaminase n=53 Tax=Saccharomycet...   375   e-103
UniRef50_A6Q7Y4 Porphobilinogen deaminase n=7 Tax=Epsilonproteob...   375   e-102
UniRef50_D0LUE1 Porphobilinogen deaminase n=1 Tax=Haliangium och...   373   e-102
UniRef50_Q43316 Porphobilinogen deaminase, chloroplastic n=61 Ta...   372   e-102
UniRef50_D2R3S6 Porphobilinogen deaminase n=2 Tax=Planctomycetac...   372   e-102
UniRef50_P28789 Porphobilinogen deaminase n=18 Tax=Saccharomycet...   371   e-101
UniRef50_A5VM67 Porphobilinogen deaminase n=9 Tax=Lactobacillus ...   370   e-101
UniRef50_Q8RFP5 Porphobilinogen deaminase n=16 Tax=Fusobacteriac...   370   e-101
UniRef50_UPI0001926E0E PREDICTED: similar to hydroxymethylbilane...   369   e-101
UniRef50_C8WXM9 Porphobilinogen deaminase n=2 Tax=Alicyclobacill...   369   e-101
UniRef50_B3T8H9 Putative Porphobilinogen deaminase, dipyromethan...   369   e-100
UniRef50_A9A1A1 Probable porphobilinogen deaminase n=3 Tax=Thaum...   369   e-100
UniRef50_A8LIJ6 Porphobilinogen deaminase n=11 Tax=Alphaproteoba...   368   e-100
UniRef50_UPI00017922DC PREDICTED: similar to porphobilinogen dea...   368   e-100
UniRef50_C1CYD9 Porphobilinogen deaminase n=3 Tax=Deinococci Rep...   367   e-100
UniRef50_D1CBT4 Porphobilinogen deaminase n=1 Tax=Thermobaculum ...   367   e-100
UniRef50_C3WGN0 Porphobilinogen deaminase n=5 Tax=Fusobacterium ...   366   e-100
UniRef50_Q3YSA8 Porphobilinogen deaminase n=17 Tax=Rickettsiales...   365   e-100
UniRef50_B0K2L4 Porphobilinogen deaminase n=7 Tax=Bacteria RepID...   364   2e-99
UniRef50_UPI0000583C22 PREDICTED: hypothetical protein n=1 Tax=S...   363   4e-99
UniRef50_C3XEZ5 Porphobilinogen deaminase n=3 Tax=Campylobactera...   362   1e-98
UniRef50_Q5HBG1 Porphobilinogen deaminase n=2 Tax=Ehrlichia rumi...   360   3e-98
UniRef50_C6XGK7 Porphobilinogen deaminase n=1 Tax=Candidatus Lib...   359   6e-98
UniRef50_Q2S2A6 Porphobilinogen deaminase n=1 Tax=Salinibacter r...   359   1e-97
UniRef50_D0NJW2 Porphobilinogen deaminase n=2 Tax=Phytophthora i...   358   2e-97
UniRef50_Q4HT06 Porphobilinogen deaminase n=1 Tax=Campylobacter ...   357   3e-97
UniRef50_C7N5L0 Porphobilinogen deaminase n=2 Tax=Slackia RepID=...   357   3e-97
UniRef50_Q11XT5 Porphobilinogen deaminase n=8 Tax=Bacteria RepID...   354   2e-96
UniRef50_A6GB01 Porphobilinogen deaminase n=2 Tax=Bacteria RepID...   354   2e-96
UniRef50_A6DBT5 Porphobilinogen deaminase n=1 Tax=Caminibacter m...   354   2e-96
UniRef50_A8U3E9 Porphobilinogen deaminase n=1 Tax=alpha proteoba...   353   6e-96
UniRef50_B3U3W9 Hydroxymethylbilane synthetase n=1 Tax=Oxyrrhis ...   352   9e-96
UniRef50_A6GVP0 Hydroxymethylbilane synthase n=18 Tax=Bacteroide...   352   1e-95
UniRef50_C4Z552 Porphobilinogen deaminase n=8 Tax=Bacteria RepID...   350   2e-95
UniRef50_B2W5W6 Porphobilinogen deaminase n=2 Tax=Pleosporineae ...   350   2e-95
UniRef50_UPI00006CBE06 porphobilinogen deaminase family protein ...   350   4e-95
UniRef50_C6WZF5 Porphobilinogen deaminase n=1 Tax=Flavobacteriac...   350   4e-95
UniRef50_A9FDP9 Porphobilinogen deaminase n=1 Tax=Sorangium cell...   349   6e-95
UniRef50_A3CL78 Porphobilinogen deaminase n=1 Tax=Streptococcus ...   347   2e-94
UniRef50_Q1V167 Hydroxymethylbilane synthase n=3 Tax=Candidatus ...   347   3e-94
UniRef50_A0LRF1 Porphobilinogen deaminase n=1 Tax=Acidothermus c...   347   4e-94
UniRef50_A2Q9P7 Catalytic activity: 4 porphobilinogen+H(2)O<=>hy...   345   9e-94
UniRef50_C0YV01 Hydroxymethylbilane synthase n=1 Tax=Chryseobact...   344   2e-93
UniRef50_Q0TQG4 Porphobilinogen deaminase n=32 Tax=Clostridium R...   344   2e-93
UniRef50_C3PNS9 Porphobilinogen deaminase n=15 Tax=Rickettsia Re...   343   4e-93
UniRef50_C1AA38 Porphobilinogen deaminase n=1 Tax=Gemmatimonas a...   343   5e-93
UniRef50_A8MDU3 Probable porphobilinogen deaminase n=2 Tax=Therm...   343   5e-93
UniRef50_C1ZK04 Porphobilinogen deaminase n=1 Tax=Planctomyces l...   342   8e-93
UniRef50_A3ZKX4 Porphobilinogen deaminase n=1 Tax=Blastopirellul...   342   1e-92
UniRef50_C4ZFT9 Porphobilinogen deaminase n=1 Tax=Eubacterium re...   342   1e-92
UniRef50_A5CDH4 Porphobilinogen deaminase n=2 Tax=Orientia tsuts...   340   3e-92
UniRef50_B3DZQ6 Porphobilinogen deaminase n=1 Tax=Methylacidiphi...   339   7e-92
UniRef50_B8MVK7 Porphobilinogen deaminase, putative n=1 Tax=Tala...   339   7e-92
UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia...   339   8e-92
UniRef50_Q0BX92 Porphobilinogen deaminase n=1 Tax=Hyphomonas nep...   338   1e-91
UniRef50_A2BL26 Probable porphobilinogen deaminase n=2 Tax=Therm...   338   1e-91
UniRef50_B5G8F1 Porphobilinogen deaminase n=1 Tax=Streptomyces s...   336   5e-91
UniRef50_A4XK06 Porphobilinogen deaminase n=2 Tax=Clostridia Rep...   336   5e-91
UniRef50_C7NFP7 Hydroxymethylbilane synthase n=7 Tax=Actinomycet...   335   8e-91
UniRef50_Q09899 Porphobilinogen deaminase n=2 Tax=Schizosaccharo...   335   8e-91
UniRef50_C8WIZ2 Porphobilinogen deaminase n=2 Tax=Coriobacteriac...   334   3e-90
UniRef50_A8SQW4 Putative uncharacterized protein n=1 Tax=Coproco...   334   3e-90
UniRef50_A8MGE4 Porphobilinogen deaminase n=30 Tax=cellular orga...   333   4e-90
UniRef50_B9XN63 Porphobilinogen deaminase n=1 Tax=bacterium Elli...   332   7e-90
UniRef50_A4QB59 Porphobilinogen deaminase n=15 Tax=Corynebacteri...   332   9e-90
UniRef50_Q82P95 Porphobilinogen deaminase 2 n=14 Tax=Actinomycet...   332   1e-89
UniRef50_C1F251 Hydroxymethylbilane synthase n=1 Tax=Acidobacter...   332   1e-89
UniRef50_Q8TXC8 Probable porphobilinogen deaminase n=1 Tax=Metha...   332   1e-89
UniRef50_A0DD68 Chromosome undetermined scaffold_46, whole genom...   331   2e-89
UniRef50_B8GXG1 Porphobilinogen deaminase n=8 Tax=Caulobacterace...   331   2e-89
UniRef50_B0D5Q2 Predicted protein n=1 Tax=Laccaria bicolor S238N...   331   2e-89
UniRef50_D0J8N1 Porphobilinogen deaminase n=2 Tax=Blattabacteriu...   331   2e-89
UniRef50_C6XKH7 Porphobilinogen deaminase n=1 Tax=Hirschia balti...   330   3e-89
UniRef50_B6W7F3 Putative uncharacterized protein n=1 Tax=Anaeroc...   330   5e-89
UniRef50_Q7UPN0 Porphobilinogen deaminase n=1 Tax=Rhodopirellula...   330   5e-89
UniRef50_B2IAW6 Porphobilinogen deaminase n=4 Tax=Alphaproteobac...   328   1e-88
UniRef50_Q46CH0 Probable porphobilinogen deaminase n=7 Tax=Eurya...   328   2e-88
UniRef50_C4QMG7 Hydroxymethylbilane synthase (Porphobilinogen de...   327   3e-88
UniRef50_C5RMN3 Porphobilinogen deaminase n=1 Tax=Clostridium ce...   327   4e-88
UniRef50_O29026 Probable porphobilinogen deaminase n=1 Tax=Archa...   327   4e-88
UniRef50_D1BFI8 Hydroxymethylbilane synthase n=4 Tax=Actinomycet...   327   5e-88
UniRef50_C2FZW8 Porphobilinogen deaminase n=2 Tax=Sphingobacteri...   326   6e-88
UniRef50_A4CHM3 Porphobilinogen deaminase n=4 Tax=Bacteroidetes ...   325   1e-87
UniRef50_B3RTQ8 Putative uncharacterized protein n=1 Tax=Trichop...   325   1e-87
UniRef50_Q47LA7 Porphobilinogen deaminase n=3 Tax=Actinomycetale...   324   2e-87
UniRef50_C9M5W1 Hydroxymethylbilane synthase n=1 Tax=Jonquetella...   324   2e-87
UniRef50_Q4T5L1 Chromosome undetermined SCAF9206, whole genome s...   324   3e-87
UniRef50_A8AAB4 Probable porphobilinogen deaminase n=1 Tax=Ignic...   324   3e-87
UniRef50_D2RH82 Porphobilinogen deaminase n=2 Tax=Archaeoglobace...   323   4e-87
UniRef50_C6XST0 Porphobilinogen deaminase n=2 Tax=Pedobacter Rep...   323   4e-87
UniRef50_A3MLK5 Porphobilinogen deaminase n=155 Tax=Proteobacter...   323   6e-87
UniRef50_D2NS36 Porphobilinogen deaminase n=2 Tax=Micrococcaceae...   322   1e-86
UniRef50_C1TM53 Porphobilinogen deaminase n=1 Tax=Dethiosulfovib...   322   1e-86
UniRef50_UPI000174444E Hydroxymethylbilane synthase n=1 Tax=Verr...   322   1e-86
UniRef50_C2GGB5 Porphobilinogen deaminase n=2 Tax=Corynebacteriu...   322   1e-86
UniRef50_D1VCA1 Porphobilinogen deaminase n=1 Tax=Frankia sp. Eu...   321   2e-86
UniRef50_A4WN24 Probable porphobilinogen deaminase n=3 Tax=Therm...   321   2e-86
UniRef50_Q2NEP4 HemC n=4 Tax=Methanobacteriaceae RepID=Q2NEP4_METST   320   3e-86
UniRef50_Q9F7M2 Predicted porphobilinogen deaminase n=2 Tax=Bact...   320   4e-86
UniRef50_C6R3Y0 Hydroxymethylbilane synthase n=1 Tax=Rothia muci...   319   7e-86
UniRef50_A0QLI0 Porphobilinogen deaminase n=69 Tax=Actinomycetal...   318   2e-85
UniRef50_Q8D2W2 HemC protein n=1 Tax=Wigglesworthia glossinidia ...   318   2e-85
UniRef50_C0BZ93 Putative uncharacterized protein n=1 Tax=Clostri...   318   2e-85
UniRef50_Q57989 Probable porphobilinogen deaminase n=11 Tax=Meth...   317   4e-85
UniRef50_A1DGB8 Porphobilinogen deaminase n=1 Tax=Neosartorya fi...   316   5e-85
UniRef50_UPI0001BC2D4C glutamyl-tRNA reductase n=1 Tax=Brevibact...   316   8e-85
UniRef50_D1C4S0 Porphobilinogen deaminase n=1 Tax=Sphaerobacter ...   315   9e-85
UniRef50_O26960 Probable porphobilinogen deaminase n=1 Tax=Metha...   315   1e-84
UniRef50_Q1EPC8 Porphobilinogen deaminase, chloroplast (Hydroxym...   315   1e-84
UniRef50_C5CB88 Porphobilinogen deaminase n=5 Tax=Actinomycetale...   314   2e-84
UniRef50_B6JII8 Porphobilinogen deaminase n=11 Tax=Bradyrhizobia...   313   6e-84
UniRef50_C9RPT6 Porphobilinogen deaminase n=1 Tax=Fibrobacter su...   312   9e-84
UniRef50_Q6AHF1 Porphobilinogen deaminase n=5 Tax=Actinobacteria...   310   3e-83
UniRef50_A3VPD5 Porphobilinogen deaminase n=1 Tax=Parvularcula b...   308   1e-82
UniRef50_A8PWJ5 Putative uncharacterized protein n=1 Tax=Malasse...   308   1e-82
UniRef50_C5EV71 Pyruvate ferredoxin/flavodoxin oxidoreductase n=...   308   2e-82
UniRef50_B2ULP1 Porphobilinogen deaminase n=1 Tax=Akkermansia mu...   306   8e-82
UniRef50_A2SQU4 Uroporphyrin-III C-methyltransferase n=11 Tax=Eu...   305   1e-81
UniRef50_A6LKX0 Porphobilinogen deaminase n=1 Tax=Thermosipho me...   305   2e-81
UniRef50_Q6L2G8 Probable porphobilinogen deaminase n=1 Tax=Picro...   304   3e-81
UniRef50_C7DH16 Porphobilinogen deaminase n=1 Tax=Candidatus Mic...   303   5e-81
UniRef50_C6V4N6 Porphobilinogen deaminase n=2 Tax=Neorickettsia ...   303   5e-81
UniRef50_B3LB83 Porphobilinogen deaminase, putative n=1 Tax=Plas...   303   7e-81
UniRef50_D1B7N1 Porphobilinogen deaminase n=1 Tax=Thermanaerovib...   303   7e-81
UniRef50_Q5KKQ0 Hydroxymethylbilane synthase, putative n=2 Tax=F...   302   2e-80
UniRef50_Q0ATQ1 Porphobilinogen deaminase n=3 Tax=Alphaproteobac...   302   2e-80
UniRef50_B5GJG2 Porphobilinogen deaminase n=3 Tax=Streptomyces R...   300   3e-80
UniRef50_C7M2H5 Porphobilinogen deaminase n=1 Tax=Acidimicrobium...   300   5e-80
UniRef50_Q1AUK3 Porphobilinogen deaminase n=1 Tax=Rubrobacter xy...   299   8e-80
UniRef50_A4YD92 Probable porphobilinogen deaminase n=1 Tax=Metal...   298   2e-79
UniRef50_C7R376 Porphobilinogen deaminase n=1 Tax=Jonesia denitr...   298   2e-79
UniRef50_D1JID7 Porphobilinogen deaminase n=1 Tax=uncultured arc...   297   3e-79
UniRef50_C4JRY9 Porphobilinogen deaminase n=1 Tax=Uncinocarpus r...   296   8e-79
UniRef50_A9HK97 Porphobilinogen deaminase n=12 Tax=Acetobacterac...   295   1e-78
UniRef50_B5JN62 Porphobilinogen deaminase n=1 Tax=Verrucomicrobi...   295   1e-78
UniRef50_Q2FTK7 Hydroxymethylbilane synthase n=3 Tax=Methanomicr...   293   4e-78
UniRef50_C3MZR8 Probable porphobilinogen deaminase n=11 Tax=Sulf...   293   5e-78
UniRef50_D2RNT2 Porphobilinogen deaminase n=1 Tax=Acidaminococcu...   292   8e-78
UniRef50_C0W553 Porphobilinogen deaminase n=2 Tax=Actinomycetale...   291   2e-77
UniRef50_Q4PFH9 Putative uncharacterized protein n=1 Tax=Ustilag...   291   3e-77
UniRef50_C8WDJ7 Porphobilinogen deaminase n=3 Tax=Zymomonas mobi...   285   1e-75
UniRef50_Q97B26 Probable porphobilinogen deaminase n=2 Tax=Therm...   284   3e-75
UniRef50_A2BFN7 Hydroxymethylbilane synthase (Fragment) n=6 Tax=...   283   4e-75
UniRef50_C1XV35 Porphobilinogen deaminase n=2 Tax=Meiothermus Re...   283   5e-75
UniRef50_C5C5B3 Porphobilinogen deaminase n=6 Tax=Actinomycetale...   282   1e-74
UniRef50_Q8I5V3 Porphobilinogen deaminase n=6 Tax=Plasmodium Rep...   281   2e-74
UniRef50_B4D5X7 Porphobilinogen deaminase n=1 Tax=Chthoniobacter...   281   2e-74
UniRef50_B0WMK9 Porphobilinogen deaminase n=1 Tax=Culex quinquef...   281   3e-74
UniRef50_Q93A65 Porphobilinogen deaminase n=1 Tax=uncultured bac...   280   4e-74
UniRef50_Q9Y9J0 Probable porphobilinogen deaminase n=1 Tax=Aerop...   280   4e-74
UniRef50_Q0RS16 Porphobilinogen deaminase 1 (PBG 1) (Hydroxymeth...   278   1e-73
UniRef50_Q1GP41 Porphobilinogen deaminase n=7 Tax=Sphingomonadal...   274   2e-72
UniRef50_Q83H95 Porphobilinogen deaminase n=2 Tax=Tropheryma whi...   271   3e-71
UniRef50_UPI000038E213 porphobilinogen deaminase n=1 Tax=Ferropl...   270   7e-71
UniRef50_A9V9E0 Predicted protein n=1 Tax=Monosiga brevicollis R...   268   2e-70
UniRef50_UPI0001C31A39 porphobilinogen deaminase n=1 Tax=Conexib...   262   1e-68
UniRef50_Q04X38 Bifunctional porphobilinogen deaminase/uroporphy...   262   1e-68
UniRef50_B0SF66 Bifunctional porphobilinogen deaminase/uroporphy...   261   2e-68
UniRef50_A7BMK1 Porphobilinogen deaminase n=1 Tax=Beggiatoa sp. ...   261   2e-68
UniRef50_A5K0J5 Porphobilinogen deaminase, putative n=1 Tax=Plas...   258   1e-67
UniRef50_B1ZV87 Porphobilinogen deaminase n=2 Tax=Opitutaceae Re...   254   4e-66
UniRef50_Q86ET2 Clone ZZD1450 mRNA sequence n=3 Tax=Schistosoma ...   243   7e-63
UniRef50_C0EAN0 Putative uncharacterized protein n=1 Tax=Clostri...   237   4e-61
UniRef50_Q6MHU0 Hydroxymethylbilane synthase n=1 Tax=Bdellovibri...   235   1e-60
UniRef50_Q4E9D5 Porphobilinogen deaminase (Fragment) n=1 Tax=Wol...   233   8e-60
UniRef50_B6YQR9 Hydroxymethylbilane synthase/uroporphyrin-III C-...   225   2e-57
UniRef50_Q6MEK3 Putative Porphobilinogen deaminase n=2 Tax=Parac...   224   3e-57
UniRef50_B4UXX3 Porphobilinogen deaminase 2 (Fragment) n=1 Tax=S...   223   8e-57
UniRef50_A8I2X7 Porphobilinogen deaminase n=1 Tax=Chlamydomonas ...   218   1e-55
UniRef50_Q6Q923 Predicted porphobilinogen deaminase n=2 Tax=envi...   210   5e-53
UniRef50_Q9PK95 Probable porphobilinogen deaminase n=13 Tax=Chla...   207   3e-52
UniRef50_D0RNS6 Putative porphobilinogen deaminase (Pbg)(Hydroxy...   203   6e-51
UniRef50_C5LJF7 Porphobilinogen deaminase, putative n=5 Tax=Perk...   200   4e-50
UniRef50_Q9HMY5 Probable porphobilinogen deaminase n=2 Tax=Halob...   196   1e-48
UniRef50_Q18ES3 Hydroxymethylbilane synthase (Porphobilinogen de...   181   2e-44
UniRef50_UPI000155526F PREDICTED: similar to hydroxymethylbilane...   166   1e-39
UniRef50_B0KCR7 Porphobilinogen deaminase n=3 Tax=Thermoanaeroba...   161   3e-38
UniRef50_C0DZX9 Putative uncharacterized protein n=1 Tax=Coryneb...   154   3e-36
UniRef50_UPI0001B4213A porphobilinogen deaminase n=1 Tax=Listeri...   144   3e-33
UniRef50_A8CBG6 Porphobilinogen deaminase n=3 Tax=Toxoplasma gon...   143   8e-33
UniRef50_UPI0001742E92 Porphobilinogen deaminase n=1 Tax=candida...   133   1e-29
UniRef50_C4Z1K5 Putative uncharacterized protein n=1 Tax=Eubacte...   126   1e-27
UniRef50_Q401C3 Hydroxymethylbilane synthase (Fragment) n=7 Tax=...   124   6e-27
UniRef50_UPI0001698669 porphobilinogen deaminase n=1 Tax=Endorif...   120   5e-26
UniRef50_Q1HRH6 Hydroxymethylbilane synthase-like protein n=1 Ta...   118   2e-25
UniRef50_C5G109 Porphobilinogen deaminase n=1 Tax=Microsporum ca...   112   2e-23
UniRef50_B8N6H4 Putative uncharacterized protein n=1 Tax=Aspergi...   100   6e-20
UniRef50_UPI0000D9FBB5 PREDICTED: similar to lethal (3) 02640 CG...   100   1e-19
UniRef50_UPI0001C35DE1 porphobilinogen deaminase n=1 Tax=Clostri...    89   2e-16
UniRef50_C5U771 Porphobilinogen deaminase n=1 Tax=Methanocaldoco...    74   9e-12
UniRef50_Q4EB45 Porphobilinogen deaminase n=1 Tax=Wolbachia endo...    63   1e-08
UniRef50_B5XH53 Porphobilinogen deaminase n=1 Tax=Salmo salar Re...    60   1e-07
UniRef50_C2BR76 Putative uncharacterized protein (Fragment) n=1 ...    59   2e-07

Sequences not found previously or not previously below threshold:

UniRef50_UPI0000D537E6 hypothetical protein P700755_22735 n=1 Ta...    55   3e-06

>UniRef50_B7LU53 Porphobilinogen deaminase n=87 Tax=cellular organisms
           RepID=HEM3_ESCF3
          Length = 313

 Score =  447 bits (1151), Expect = e-124,   Method: Composition-based stats.
 Identities = 296/312 (94%), Positives = 302/312 (96%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           MLDNVLRIATRQSPLALWQAHYVKD LMA HPGL VELVPMVTRGDVILDTPLAKVGGKG
Sbjct: 1   MLDNVLRIATRQSPLALWQAHYVKDALMAKHPGLTVELVPMVTRGDVILDTPLAKVGGKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN Y SLD LP
Sbjct: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNKYASLDELP 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
           AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE
Sbjct: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
           SRIR ALPPE+SLPAVGQGAVGIECRLDD+RTRELLAALNH ETALRVTAERAMNTRLEG
Sbjct: 181 SRIRDALPPEVSLPAVGQGAVGIECRLDDTRTRELLAALNHPETALRVTAERAMNTRLEG 240

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           GCQVPIGSYAELI GEIWLRALVGAPDGSQ+IRGERRG+PQDAE+MGISLAEELLNNGAR
Sbjct: 241 GCQVPIGSYAELIGGEIWLRALVGAPDGSQMIRGERRGSPQDAEKMGISLAEELLNNGAR 300

Query: 301 EILAEVYNGDAP 312
            ILA+VYNGDAP
Sbjct: 301 AILADVYNGDAP 312


>UniRef50_B5FN93 Porphobilinogen deaminase n=168 Tax=cellular organisms
           RepID=HEM3_SALDC
          Length = 313

 Score =  440 bits (1133), Expect = e-122,   Method: Composition-based stats.
 Identities = 279/313 (89%), Positives = 294/313 (93%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           MLDNVLRIATRQSPLALWQAHYVKD LMA+HPGL VELVPMVTRGDVILDTPLAKVGGKG
Sbjct: 1   MLDNVLRIATRQSPLALWQAHYVKDALMATHPGLTVELVPMVTRGDVILDTPLAKVGGKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKELE+ALLE RADIAVHSMKDVPV FP GLGLVTICEREDPRDAFVSN Y SLD LP
Sbjct: 61  LFVKELEIALLEKRADIAVHSMKDVPVAFPDGLGLVTICEREDPRDAFVSNKYHSLDDLP 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
           AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRL KLDNG+YDAIILAVAGLKRLGLE
Sbjct: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLGKLDNGDYDAIILAVAGLKRLGLE 180

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
           SRIR ALPP++SLPAVGQGAVGIECRLDD+RT+ LLA LNH +TALRVTAERAMNTRLEG
Sbjct: 181 SRIRTALPPDVSLPAVGQGAVGIECRLDDARTQALLAPLNHSQTALRVTAERAMNTRLEG 240

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           GCQVPIGSYAE+I+GEIWLRALVGAPDGS ++RGERRG+P+ AEQMGISLAEELL NGAR
Sbjct: 241 GCQVPIGSYAEIINGEIWLRALVGAPDGSVMVRGERRGSPEQAEQMGISLAEELLENGAR 300

Query: 301 EILAEVYNGDAPA 313
            IL EVYNG+ PA
Sbjct: 301 AILTEVYNGETPA 313


>UniRef50_Q3ACT3 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=HEM3_CARHZ
          Length = 311

 Score =  436 bits (1123), Expect = e-121,   Method: Composition-based stats.
 Identities = 146/310 (47%), Positives = 202/310 (65%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   + + +R S LALWQ ++V ++L   HP +  ++V M T+GD ILD  LAK+G KGL
Sbjct: 1   MKKEVIVGSRDSALALWQTNWVVERLSKIHPEINFKIVTMKTKGDKILDVALAKIGDKGL 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F KELE ALL    D+AVHSMKD+P   P+GL +   CERE P D F+S        LP 
Sbjct: 61  FTKELEHALLNKTIDMAVHSMKDLPTVLPEGLKIGAFCEREYPGDVFISPKGFKFLELPQ 120

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ +GTSSLRR  Q+   RPDL    LRGN+ TR  K++  + D IILA AG+KRLG E 
Sbjct: 121 GARIGTSSLRRIAQILAVRPDLQAIPLRGNLPTRFRKMEEMDLDGIILAYAGVKRLGYED 180

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
           +I   L  ++ LPAVGQG++G+E R DD+   ELL  ++H  T   + AERA   RLEGG
Sbjct: 181 KITEMLSFDLCLPAVGQGSIGVEIRADDTFIEELLKPIDHFATNRAIRAERAFLKRLEGG 240

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           CQ+PIG+Y+E+ +  + L+ +V + DG  +I+GE+ G+ ++ E++GISLAEELL  GA++
Sbjct: 241 CQIPIGAYSEVKENRLHLKGVVASLDGKLVIKGEKEGSIEEPEKVGISLAEELLTKGAQK 300

Query: 302 ILAEVYNGDA 311
           IL E+     
Sbjct: 301 ILEEIRRDAN 310


>UniRef50_C0QU69 Porphobilinogen deaminase n=4 Tax=Bacteria RepID=C0QU69_PERMH
          Length = 308

 Score =  435 bits (1119), Expect = e-120,   Method: Composition-based stats.
 Identities = 171/306 (55%), Positives = 229/306 (74%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR+S LALWQA+Y+ D+L    P L VELV +VT+GD ILD PLAKVGGKGLFVKE
Sbjct: 3   IRIGTRKSKLALWQANYIADQLKKHFPDLEVELVKIVTKGDKILDVPLAKVGGKGLFVKE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E A+L N  DIAVHS+KDVP  FP+GLGLV I EREDPRDAF+S  Y+S++ +P G+++
Sbjct: 63  IEEAMLRNEIDIAVHSLKDVPTYFPEGLGLVAITEREDPRDAFLSVKYNSIEDMPEGAVL 122

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSSLRR+ Q+  +R D+ I  LRGNV TR+ KL+ G+YD IILA AGLKRLGLE ++R 
Sbjct: 123 GTSSLRRKAQIMMKRKDIRIEDLRGNVDTRIRKLEEGQYDGIILAYAGLKRLGLEGKVRQ 182

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L P+  +PAV QG +GIE RLDD +TRE+++ LNH E+ +R  AERA    LEGGCQVP
Sbjct: 183 ILQPDYMIPAVAQGFLGIEARLDDEKTREIVSVLNHRESEIRAKAERAFLKTLEGGCQVP 242

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305
           +  Y+E+++G++ +   V    G ++ R    G+ +DAE +G+ LAE+LL++GA+E+L E
Sbjct: 243 LAGYSEIVNGKLKITGFVSDLTGDRVFRDSMEGSLEDAESLGVKLAEKLLSDGAKEVLEE 302

Query: 306 VYNGDA 311
           +Y+G  
Sbjct: 303 IYSGSE 308


>UniRef50_B5YJZ4 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=B5YJZ4_THEYD
          Length = 311

 Score =  429 bits (1104), Expect = e-119,   Method: Composition-based stats.
 Identities = 157/309 (50%), Positives = 219/309 (70%), Gaps = 1/309 (0%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           +  N + I +R S LA+WQA++VKDKL   +P L VE+  + T GD ILD PLAK+GGKG
Sbjct: 3   VKRNKIVIGSRGSKLAMWQANWVKDKLQTLYPELKVEIEKIKTTGDKILDAPLAKIGGKG 62

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKE+E ALL  R D+AVHSMKDVP E P+GL +  ICEREDPRDAF+S +   L+ LP
Sbjct: 63  LFVKEIEEALLSKRVDLAVHSMKDVPTEIPEGLQISAICEREDPRDAFISKDGVLLNELP 122

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
             +++GTSSLRR  QL   R DL+I+ LRGNV TR+ KL +GE+ AI+LA+AG+KR+G+E
Sbjct: 123 QEAVLGTSSLRRTVQLKALRNDLVIKPLRGNVDTRIRKLKDGEFQAIVLAMAGVKRMGVE 182

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
           + +  A   ++ +PA+GQGA+GIE R+DD    EL+  LNH ETA+ + AERA  + + G
Sbjct: 183 NLVTQAFSEDLMIPAIGQGAIGIETRVDDDFVNELIKPLNHEETAICILAERAFLSVMGG 242

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQ-IIRGERRGAPQDAEQMGISLAEELLNNGA 299
           GCQVP+  +A +++  + +  ++G P+G   +I+G R G+   A+ +G+ LA ELL+ G 
Sbjct: 243 GCQVPLACHARIVNNSLKIVGMIGDPEGKMPVIKGFREGSLSQAQSLGVELANELLHRGG 302

Query: 300 REILAEVYN 308
           +EIL +VY 
Sbjct: 303 KEILEKVYK 311


>UniRef50_C0Q9U2 HemC n=2 Tax=Bacteria RepID=C0Q9U2_DESAH
          Length = 325

 Score =  428 bits (1101), Expect = e-118,   Method: Composition-based stats.
 Identities = 146/307 (47%), Positives = 199/307 (64%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   ++I TR S LALWQA++VKD++    P   VE++ + T GD+I+D PL+ VGGKGL
Sbjct: 19  MKKTIKIGTRGSKLALWQANHVKDRIEDQFPETEVEIMTIKTTGDMIVDRPLSMVGGKGL 78

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FVKE+E ALLE+  D+AVHSMKD+P E P GL +  +  RE+P D  +SNN  SL  LP 
Sbjct: 79  FVKEIEKALLESTIDMAVHSMKDMPGELPPGLVIGAVPARENPFDVLISNNNLSLADLPK 138

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ +GTSSLRR  Q+   RPD+   S+RGN+ TRL KL  GE+DA +LA AGL RLG+++
Sbjct: 139 GARIGTSSLRRASQIKHARPDIETASIRGNLDTRLKKLAAGEFDATLLAAAGLIRLGMKT 198

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
            I       I +PAVGQGA+ IE R +D     +LA LNH ET   V+ ERA   RL+G 
Sbjct: 199 VITQYFDETIMIPAVGQGALCIESRQEDLDIAPVLAFLNHGETHTVVSGERAFLRRLDGS 258

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           C +P+  +  L D  + L  LV + DG  I++    G P+D ++ GI+LAE LL+ GA +
Sbjct: 259 CHIPVACFGRLEDHRVILTGLVASEDGRTILKETVAGTPEDPQKAGIALAETLLSKGADK 318

Query: 302 ILAEVYN 308
           IL  + +
Sbjct: 319 ILENLNS 325


>UniRef50_Q8YVU6 Porphobilinogen deaminase n=50 Tax=cellular organisms
           RepID=HEM3_ANASP
          Length = 323

 Score =  423 bits (1088), Expect = e-117,   Method: Composition-based stats.
 Identities = 151/308 (49%), Positives = 199/308 (64%), Gaps = 3/308 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             +RI +R+S LAL Q ++V+++L  S P +  E+  M T+GD ILD  LAK+G KGLF 
Sbjct: 10  RTIRIGSRKSQLALVQTYWVREQLQNSFPDINFEVHTMSTQGDKILDVALAKIGDKGLFT 69

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALP 120
           KELEV ++    D AVHS+KD+P   P+GL L  I ERE+P DA V +       +D LP
Sbjct: 70  KELEVGMINEEIDFAVHSLKDLPTNLPEGLALAAITERENPADALVVHENFKDKQIDTLP 129

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
           AG+++GTSSLRR  QL  + P L  + +RGN+ TRL+KLD GEYD +ILA AGL+RLG+ 
Sbjct: 130 AGAVIGTSSLRRLAQLRNQFPHLTFKDVRGNLNTRLAKLDAGEYDGLILAAAGLQRLGMG 189

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            R+   LP EISL AVGQGA+GIECR DD+    +L A+ H ET  R  AER+    LEG
Sbjct: 190 DRVHQILPKEISLHAVGQGALGIECRADDAELITVLKAIEHPETRDRCLAERSFLRSLEG 249

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           GCQVPIG   E+   E+ L  +V + DG  +++    G   DAE +GI LAE L   GA+
Sbjct: 250 GCQVPIGVNTEINGNELILTGVVASVDGQNLVKDTVSGNASDAEAIGIRLAELLREQGAQ 309

Query: 301 EILAEVYN 308
           EIL  ++ 
Sbjct: 310 EILNTIFA 317


>UniRef50_D1BNZ5 Porphobilinogen deaminase n=3 Tax=Veillonella RepID=D1BNZ5_VEIPT
          Length = 312

 Score =  422 bits (1087), Expect = e-117,   Method: Composition-based stats.
 Identities = 144/309 (46%), Positives = 195/309 (63%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           + + +RI TR+S LALWQA ++  +L   +P + VELV   T+GD IL+ PLA+VGGKGL
Sbjct: 1   MRDHIRIGTRKSALALWQAEHISAELQRLYPNITVELVHFNTKGDRILEKPLAQVGGKGL 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F  ELE A+     DIAVHS+KD+P E P+GL L  I  RE P DA VS  Y +LD LP 
Sbjct: 61  FTAELEEAMHAGDIDIAVHSLKDMPTELPEGLTLGAISAREVPYDALVSPVYKTLDKLPQ 120

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ VGTSSLRRQ QL   RPDL +  +RGNV TRLSK++  + D +ILA AGLKRLGLE 
Sbjct: 121 GARVGTSSLRRQAQLLHVRPDLKVEVIRGNVQTRLSKIETEKLDGVILAQAGLKRLGLED 180

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
           +I      +  +PAVGQGA+ IECR DD+   ++L  +N   T   V  ER+   +L GG
Sbjct: 181 QITQVFKADEMIPAVGQGALAIECRADDTEMLDMLDPINDEATRYAVEGERSFLRQLNGG 240

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           CQVP+G +  +  G++ L+A++ + DG  +  GE  G  +  E +G +LA+ L   G + 
Sbjct: 241 CQVPMGVHGTINKGQLTLKAMIASLDGKTVYEGEISGPAKKGEILGKNLAKALYEEGGKR 300

Query: 302 ILAEVYNGD 310
           I+  +    
Sbjct: 301 IVDALIEEG 309


>UniRef50_Q8DIE4 Porphobilinogen deaminase n=11 Tax=cellular organisms
           RepID=HEM3_THEEB
          Length = 320

 Score =  419 bits (1077), Expect = e-116,   Method: Composition-based stats.
 Identities = 151/314 (48%), Positives = 199/314 (63%), Gaps = 3/314 (0%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
               +RI +R+S LAL Q  +V+ +L   H     E+V M T+GD ILD  LAK+G KGL
Sbjct: 5   SSRPVRIGSRKSQLALVQTEWVQAQLQTHHRDRAFEVVTMTTQGDNILDVALAKIGDKGL 64

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDA 118
           F KELE+++L    D+AVHS+KD+P + P GL L  I EREDP DA V        ++D 
Sbjct: 65  FTKELELSMLRGETDLAVHSLKDLPTQLPDGLVLAAITEREDPADALVLGAKWTGHTIDT 124

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178
           LP G+++GTSSLRR  QL    P L  + +RGN+ TRL+KLD GEYDA+ILAVAGL+RLG
Sbjct: 125 LPEGTVIGTSSLRRLAQLRHYYPHLTFKDVRGNLNTRLAKLDAGEYDALILAVAGLRRLG 184

Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
              RI   LP  +SL AVGQGA+GIECR +D+    L+  L H ET  R  AERA   +L
Sbjct: 185 FGDRISQVLPATVSLYAVGQGALGIECRAEDADILALVKTLEHPETTARCLAERAFLRQL 244

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
           EGGCQVPIG +  + +G++ L  LV + DG ++++    G    AE++G  LA +L   G
Sbjct: 245 EGGCQVPIGVHTVIENGQLTLTGLVASLDGQRLVKDSLTGDVATAEELGTRLALKLREQG 304

Query: 299 AREILAEVYNGDAP 312
           A EIL E++    P
Sbjct: 305 ASEILEEIFATVRP 318


>UniRef50_Q0I178 Porphobilinogen deaminase n=45 Tax=Bacteria RepID=HEM3_HAES1
          Length = 321

 Score =  415 bits (1068), Expect = e-115,   Method: Composition-based stats.
 Identities = 199/317 (62%), Positives = 235/317 (74%), Gaps = 11/317 (3%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62
           +  L+IATRQSPLALWQA+YVK++L   +  L VELVP++T+GDVILDTPLAK+GGKGLF
Sbjct: 4   NKTLKIATRQSPLALWQANYVKNRLQQRYSHLSVELVPIITKGDVILDTPLAKIGGKGLF 63

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122
           VKELE ALL   ADIAVHSMKDVP++FP+GL L  IC REDPRDAFVSN Y +LD LP G
Sbjct: 64  VKELENALLNGEADIAVHSMKDVPMQFPKGLELSVICPREDPRDAFVSNKYRTLDELPQG 123

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           +IVGTSSLRRQCQL   R DL IRSLRGNVGTRL+KLD G+YDAIILA AGL RLGL  R
Sbjct: 124 AIVGTSSLRRQCQLKNWRADLDIRSLRGNVGTRLNKLDQGDYDAIILASAGLIRLGLTER 183

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
           IR+ +  +  LPA GQGAVGIECR+DD   + LL  L    T   V AERAMN  L+GGC
Sbjct: 184 IRSFIEIDTILPACGQGAVGIECRVDDRDVQSLLMPLADQTTTYCVLAERAMNFHLQGGC 243

Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE-----------RRGAPQDAEQMGISLA 291
           QVPIG+YA L + +++LR LVG   GSQI+  E            + A Q AE++G+S+A
Sbjct: 244 QVPIGAYAILENNQLYLRGLVGDVHGSQILSAEGQFELSLDFESSQSAVQKAEELGVSIA 303

Query: 292 EELLNNGAREILAEVYN 308
           E+LL  GA +IL  VY 
Sbjct: 304 EQLLQQGADKILQAVYQ 320


>UniRef50_Q65GK1 Porphobilinogen deaminase n=98 Tax=Bacillales RepID=HEM3_BACLD
          Length = 313

 Score =  414 bits (1066), Expect = e-114,   Method: Composition-based stats.
 Identities = 143/307 (46%), Positives = 188/307 (61%), Gaps = 4/307 (1%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             + + +R+S LA+ Q  +V  KL   +P    E+  +VT+GD ILD  L+KVGGKGLFV
Sbjct: 2   RNIIVGSRRSKLAMTQTKWVIKKLEELNPDFTFEIKEIVTKGDRILDVTLSKVGGKGLFV 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KE+E A+L    D+AVHSMKD+P   P+GL +  I +RED RD  +S     L  L  G+
Sbjct: 62  KEIEQAMLSGEIDMAVHSMKDMPSVLPEGLMVGCIPKREDARDVLISKGRQKLADLKQGA 121

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL-ESR 182
           +VGTSSLRR  QL + RPDL I+ +RGN+ TRL KL+  +YDAIILA AGL R+G  +  
Sbjct: 122 VVGTSSLRRSAQLLQMRPDLEIKWIRGNIDTRLKKLETEDYDAIILAAAGLSRMGWKDDV 181

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
           +   L PE  LPAVGQGA+ IECR  D     L + LN   T L VTAERA    +EGGC
Sbjct: 182 VTEFLDPESCLPAVGQGALAIECRGSDEELLSLFSRLNDRYTQLTVTAERAFLHAMEGGC 241

Query: 243 QVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           QVPI  +A++  DG I L  LV +PDG  + R   +G  +D E +G   A  +   GA+ 
Sbjct: 242 QVPIAGFAKMDEDGVIELTGLVASPDGKTVYRETVKG--KDPEAVGRECAAVMSEKGAKA 299

Query: 302 ILAEVYN 308
           ++  V  
Sbjct: 300 LIDRVKQ 306


>UniRef50_A1AUE7 Porphobilinogen deaminase n=44 Tax=Bacteria RepID=HEM3_PELPD
          Length = 310

 Score =  413 bits (1062), Expect = e-114,   Method: Composition-based stats.
 Identities = 167/310 (53%), Positives = 204/310 (65%), Gaps = 1/310 (0%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M    LRI TR S LALWQA++VK +L   +P + V L  + T GD ILD PLA+VGGKG
Sbjct: 1   MPPRQLRIGTRASQLALWQANWVKSELEKRYPAMEVTLTKIKTMGDRILDVPLAQVGGKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKE+E A+L    DIAVHSMKDVP EFP+GLGL  I EREDPRDA VS        LP
Sbjct: 61  LFVKEIEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVVSR-AARFSHLP 119

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ VGTS+LRRQ QL   RPDL + ++RGNV TR+ KLD    DA+ILA AGLKRLGL 
Sbjct: 120 PGARVGTSALRRQAQLLHARPDLEMVTIRGNVETRIRKLDEENLDAVILAAAGLKRLGLT 179

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            R+   L  E S+PA+GQGA+GIECRL D    E +A  NH +T+  V AERA+  R +G
Sbjct: 180 QRVAEYLDVEFSIPAIGQGALGIECRLSDPVVTEAIAFFNHPDTSHAVRAERALLRRCQG 239

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           GCQVPI ++  +  GE+ L  L+ A DG + +R E  G     E +G  LA+ LL+ G R
Sbjct: 240 GCQVPIAAHGTIRGGELRLVGLIAAVDGREFVRDEISGPVDQCEHLGEELADRLLSRGGR 299

Query: 301 EILAEVYNGD 310
            IL EVY  +
Sbjct: 300 AILEEVYQRE 309


>UniRef50_B5EBG8 Porphobilinogen deaminase n=166 Tax=Bacteria RepID=HEM3_GEOBB
          Length = 318

 Score =  411 bits (1058), Expect = e-113,   Method: Composition-based stats.
 Identities = 158/310 (50%), Positives = 205/310 (66%), Gaps = 1/310 (0%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M    LRI TR S LALWQA++VK +L   +P + V L  + T GD ILD PLA+VGGKG
Sbjct: 1   MALKELRIGTRASQLALWQANWVKSELEKRYPDMTVTLTKIKTIGDKILDVPLAQVGGKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKE+E A+L    DIAVHSMKDVP EFP+GLGL  I EREDPRDA +SN       LP
Sbjct: 61  LFVKEIEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVISN-GVKFADLP 119

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ +GTS+LRRQ QL + RPDL +  +RGNV TR+ KL     DA+ILA AGL RLG  
Sbjct: 120 QGARIGTSALRRQAQLLKVRPDLEMVIIRGNVQTRMDKLKTEGLDAVILAAAGLNRLGFA 179

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            +I   LP ++SLPA+GQGA+GIEC L +   ++ ++  N  +T+  V AERA+  R EG
Sbjct: 180 DQITEMLPTDLSLPAIGQGALGIECNLSNQDVKDAISFFNSPDTSRAVRAERALLWRCEG 239

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           GCQVPI ++ E+   ++ L   + + DG   ++G   G   D E++G+ LAE+LL+ G  
Sbjct: 240 GCQVPIAAFGEVTGDQLKLTGFIASVDGKVSVKGVVTGPADDCEKLGVKLAEQLLSEGGH 299

Query: 301 EILAEVYNGD 310
            ILAEVY  +
Sbjct: 300 AILAEVYQRE 309


>UniRef50_A6TJD5 Porphobilinogen deaminase n=2 Tax=Firmicutes RepID=HEM3_ALKMQ
          Length = 316

 Score =  410 bits (1054), Expect = e-113,   Method: Composition-based stats.
 Identities = 139/308 (45%), Positives = 191/308 (62%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             ++I +R S LAL QA  + + L    P    E++ + T GD ILD  L K+GGKGLFV
Sbjct: 2   RTIKIGSRASQLALVQAEIIINMLKEKFPQYTYEIIKITTLGDRILDKTLDKIGGKGLFV 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KE++ AL E + D+A+HSMKD+P E P+ L L  I +REDPRD  ++    SL+ LP G+
Sbjct: 62  KEIQKALAEEKIDLAIHSMKDMPGETPEELVLGAITKREDPRDVLITRENKSLEELPKGA 121

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           ++G+SSLRRQ Q+   R D+ +  +RGNVGTRL K++    D +ILA AGL RLGL+ +I
Sbjct: 122 VIGSSSLRRQAQVMALRGDIKVVPIRGNVGTRLGKIETESLDGVILAAAGLNRLGLKEKI 181

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
            + L  E   PAVGQGA+G E R  D    E+L A+NH ET   V AERA    LEGGC 
Sbjct: 182 SSYLEIEDFTPAVGQGALGCEARRKDIEMLEMLLAINHEETYRCVMAERAFLKLLEGGCH 241

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           VPIG+Y +    E+ +  +V + DG ++I+ +  G   D + +GI L E L+  GA+EIL
Sbjct: 242 VPIGAYGQQQGQELHMTGMVASSDGRRVIKEQVMGDIADFQALGIQLGETLIEKGAKEIL 301

Query: 304 AEVYNGDA 311
             V   + 
Sbjct: 302 ETVNTDNR 309


>UniRef50_C9KL85 Hydroxymethylbilane synthase n=1 Tax=Mitsuokella multacida DSM
           20544 RepID=C9KL85_9FIRM
          Length = 315

 Score =  409 bits (1051), Expect = e-113,   Method: Composition-based stats.
 Identities = 162/307 (52%), Positives = 201/307 (65%), Gaps = 1/307 (0%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M ++ + I TR S LALWQA YV D L   +P L VE   M T+GD ILD PLAK+GGKG
Sbjct: 1   MKNDTIVIGTRSSKLALWQADYVADCLRKRYPELRVEKKLMTTKGDKILDAPLAKIGGKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LF KELE  +L    DIAVHS+KD+P E P+GL +  I ER DP DA VS  Y +L+ LP
Sbjct: 61  LFTKELEQDMLAGGIDIAVHSLKDMPTEVPEGLVISAITERFDPGDAVVSPKYRTLENLP 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ VGTSSLRR+ QL   RPDL I  LRGNV TRL KL+   +DAIILAVAGLKRLG  
Sbjct: 121 QGAKVGTSSLRRKAQLLHARPDLQISDLRGNVNTRLEKLEREHFDAIILAVAGLKRLGFA 180

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            RI   LP E+ LPAVGQGA+ IE R +D   R L+A LN   T     AERA   R+EG
Sbjct: 181 DRITEVLPREMVLPAVGQGALAIETRENDREVRNLIAFLNDEATVACARAERAFLARVEG 240

Query: 241 GCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
           GCQVP+G YA    +G + + A++ + DG+++ R    G+  +AE +G +LA++LL  G 
Sbjct: 241 GCQVPVGVYAVPEAEGRLHVEAVIASLDGARLYRDAAVGSAAEAESLGTALADKLLAMGG 300

Query: 300 REILAEV 306
             IL E+
Sbjct: 301 IAILHEI 307


>UniRef50_Q31PM2 Porphobilinogen deaminase n=8 Tax=cellular organisms
           RepID=HEM3_SYNE7
          Length = 320

 Score =  406 bits (1045), Expect = e-112,   Method: Composition-based stats.
 Identities = 151/312 (48%), Positives = 200/312 (64%), Gaps = 3/312 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             +RI +R+S LAL Q H+V+ +L   +P    ++  M T+GD+ILD  LAK+G KGLF 
Sbjct: 7   RPIRIGSRKSQLALVQTHWVQGELQRLYPDRQFDVQTMSTQGDIILDVALAKIGDKGLFT 66

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALP 120
           KELEVA+L    D AVHS+KD+P   P+GL L  + EREDP DA V +       L+ LP
Sbjct: 67  KELEVAMLAGEVDFAVHSLKDLPTRLPEGLILGCVTEREDPADALVVHDRFKDHQLETLP 126

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+++GTSSLRR  QL    P L  + +RGN+ TRL+KLD GEYDA+ILA AGL+RL + 
Sbjct: 127 EGTVIGTSSLRRLAQLRHHYPHLQFKDVRGNLNTRLAKLDAGEYDALILAAAGLQRLSMA 186

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            RI   +P  +SL AVGQGA+GIECR +D    ELL AL H  T+ R  AERA    LEG
Sbjct: 187 DRIHQLIPAAVSLHAVGQGALGIECRAEDPEILELLKALEHEPTSQRCLAERAFLRELEG 246

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           GCQVPIG    + DG + L  +V + DG +++R +  G   D E +G++LA +L   GA+
Sbjct: 247 GCQVPIGVNTAIADGTLTLTGMVASLDGQRLLRDQVSGPTSDPEALGLALAAQLKAQGAK 306

Query: 301 EILAEVYNGDAP 312
           EIL E++    P
Sbjct: 307 EILDEIFATVRP 318


>UniRef50_C6HUG2 Porphobilinogen deaminase n=1 Tax=Leptospirillum ferrodiazotrophum
           RepID=C6HUG2_9BACT
          Length = 321

 Score =  402 bits (1033), Expect = e-110,   Method: Composition-based stats.
 Identities = 156/305 (51%), Positives = 205/305 (67%), Gaps = 2/305 (0%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62
            + +RI TR S LALWQA +V   +     GL  EL  + T GD+IL  PL++VGGKGLF
Sbjct: 7   SSPIRIGTRGSELALWQARHVAAMIR-HTAGLESELTIIKTTGDMILSVPLSQVGGKGLF 65

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122
           VKE+E AL+    D+AVHSMKDVP   P+GL +  I  REDPRDAFVSN Y S  +LP G
Sbjct: 66  VKEIEEALIAGTIDLAVHSMKDVPAFLPEGLEIGAILSREDPRDAFVSNAYSSFSSLPPG 125

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           + +GTSSLRR  QL +RRPDL   SLRGNVGTRL KLD  + DAIILA AGL RLG   R
Sbjct: 126 ARIGTSSLRRMAQLKKRRPDLRFESLRGNVGTRLRKLDENQIDAIILAAAGLIRLGFSDR 185

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
           IR  LP E+SLPAVGQGA+G+ECR  D R R +LA ++  ET   V AER + + L+GGC
Sbjct: 186 IREYLPVELSLPAVGQGALGLECRTGDHRIRTILARMHDPETTACVLAERGVLSALDGGC 245

Query: 243 QVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           Q+PI ++A  +   +I L A +   +G+ ++     G  ++A ++G+  A++LL+ G ++
Sbjct: 246 QLPIAAHARTISPEQIELIARILDVEGTTLLEEHTSGPAKEAHRLGVEAAQKLLSRGGQK 305

Query: 302 ILAEV 306
           IL ++
Sbjct: 306 ILTDI 310


>UniRef50_Q5ZRY6 Porphobilinogen deaminase n=6 Tax=Legionella RepID=HEM3_LEGPH
          Length = 309

 Score =  399 bits (1025), Expect = e-110,   Method: Composition-based stats.
 Identities = 153/309 (49%), Positives = 205/309 (66%), Gaps = 1/309 (0%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M   ++RIATRQSPLALWQA++V++ L+   P L +EL+PM+T GD  L   L   GGKG
Sbjct: 1   MSAKIIRIATRQSPLALWQANHVREMLVKQWPNLSIELLPMITSGDRFLKDKLLSAGGKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKELE ALL+ RAD+AVHS KD+P + P GL L  IC+R++P DA +S  + SL ALP
Sbjct: 61  LFVKELEEALLDKRADLAVHSTKDMPAQLPDGLLLTAICKRDNPFDALISPQFKSLAALP 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
             +I+GTSSLRRQ QL    P+L I++LRGN+ TRLSKL++GEY AIILA AGL+R+GL 
Sbjct: 121 KNAIIGTSSLRRQSQLLAYNPNLQIKTLRGNIHTRLSKLESGEYQAIILAAAGLERMGLA 180

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
             I   +P +I LP   QGA+ IECR DD   +EL+  LN   +AL V  ER +N +L G
Sbjct: 181 HHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELVHGLNDPISALCVHTERRVNAKLGG 240

Query: 241 GCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
            C +P   Y  + + + + LRA V   DGSQ+I  E++G   +AE +     E L+  GA
Sbjct: 241 NCHIPFAVYCTITEEKLLLLRAKVLNMDGSQMIDDEQQGKIAEAEVIADRCTESLMTKGA 300

Query: 300 REILAEVYN 308
             +L+ + +
Sbjct: 301 MSLLSTIPS 309


>UniRef50_Q2RJ26 Porphobilinogen deaminase n=5 Tax=Clostridia RepID=HEM3_MOOTA
          Length = 313

 Score =  397 bits (1020), Expect = e-109,   Method: Composition-based stats.
 Identities = 150/303 (49%), Positives = 193/303 (63%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +++ +R+S LA WQA +V   L  + PGL   LV + T+GD ILD  LA++G KGLF KE
Sbjct: 4   IKVGSRESELARWQARWVIQALEKAWPGLSCRLVTLKTKGDKILDVALARIGDKGLFTKE 63

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           LE+ALL+   D+AVHSMKD+P   P+GL +  I  REDP D  VS    +L  LP  + V
Sbjct: 64  LELALLDGAIDLAVHSMKDMPTTLPEGLVIGAIGPREDPADVLVSPEGYTLATLPIKARV 123

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSSLRR+ QLA  RPDL +  LRGNV TRL+K++     AI+LA AGLKRL     +  
Sbjct: 124 GTSSLRRKAQLAYARPDLELVDLRGNVPTRLAKMERDGLTAIVLAAAGLKRLNHGQVLGE 183

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            +P  I LPAVGQGA+G+E R  D R  EL+AA+NH  TA  V AERA    LEGGCQVP
Sbjct: 184 PIPYHICLPAVGQGAIGVEIRAGDRRVAELVAAINHPPTAAAVRAERAYLRALEGGCQVP 243

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305
           I + A + D  + L+ +V + DG +++R    G+ +D E  G  LA +LL  GA EIL E
Sbjct: 244 IAALATVEDTALVLQGMVASLDGREMLRDIASGSTRDPEAAGRELARKLLARGAGEILQE 303

Query: 306 VYN 308
           V  
Sbjct: 304 VKA 306


>UniRef50_P08397 Porphobilinogen deaminase n=59 Tax=Chordata RepID=HEM3_HUMAN
          Length = 361

 Score =  394 bits (1012), Expect = e-108,   Method: Composition-based stats.
 Identities = 145/340 (42%), Positives = 192/340 (56%), Gaps = 33/340 (9%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
            V+R+ TR+S LA  Q   V   L AS+PGL  E++ M T GD ILDT L+K+G K LF 
Sbjct: 19  RVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFT 78

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALP 120
           KELE AL +N  D+ VHS+KD+P   P G  +  IC+RE+P DA V +      +L+ LP
Sbjct: 79  KELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLP 138

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGL 179
             S+VGTSSLRR  QL  + P L  RS+RGN+ TRL KLD   E+ AIILA AGL+R+G 
Sbjct: 139 EKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQEFSAIILATAGLQRMGW 198

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
            +R+   L PE  + AVGQGA+G+E R  D    +L+  L+  ET LR  AERA    LE
Sbjct: 199 HNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLE 258

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-----------GAPQD------ 282
           GGC VP+  +  + DG+++L   V + DGS  I+   +           G   D      
Sbjct: 259 GGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIHVPAQHEDGPEDDPQLVGI 318

Query: 283 ------------AEQMGISLAEELLNNGAREILAEVYNGD 310
                       A+ +GISLA  LL+ GA+ IL      +
Sbjct: 319 TARNIPRGPQLAAQNLGISLANLLLSKGAKNILDVARQLN 358


>UniRef50_B2A1G7 Porphobilinogen deaminase n=1 Tax=Natranaerobius thermophilus
           JW/NM-WN-LF RepID=HEM3_NATTJ
          Length = 311

 Score =  393 bits (1011), Expect = e-108,   Method: Composition-based stats.
 Identities = 137/310 (44%), Positives = 195/310 (62%), Gaps = 5/310 (1%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            LRI TR+S LAL Q ++V ++L   +P + +E+  + T+GD +L+  L+KVGGKGLF+K
Sbjct: 2   KLRIGTRRSQLALDQTNWVVEQLKTHYPDIEIEIKKIETKGDQLLNVSLSKVGGKGLFLK 61

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           E++ ALL+   D+AVHSMKD+P E  + L +  I +R DP DA +SNN  ++D LP  + 
Sbjct: 62  EIQNALLQGEIDLAVHSMKDIPTETTEDLEICAITKRVDPLDALISNNDITIDELPENAK 121

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESRI 183
           +GTSSLRR  QL   R DL I  +RGN+ TR++KL    E DA++LA AGL R G+   I
Sbjct: 122 IGTSSLRRGSQLKAYRNDLQIIPIRGNINTRMNKLQELPELDAVVLAKAGLVRSGMTDSI 181

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              + PEI +P  GQGA+G+E R D+   +E LA L+  E+   + AERA   RL G C 
Sbjct: 182 SQNISPEIIVPCPGQGALGLEIRHDNENLKEKLAVLDDSESRKAIGAERAFLNRLGGSCH 241

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD----AEQMGISLAEELLNNGA 299
           VP+G+YAE+I  E+ L  +V + DG  +I+   +    D       +G  LAEEL+  GA
Sbjct: 242 VPVGAYAEIISNELHLTGVVASEDGQDVIKRSVQTHLSDNNKIPSTLGNDLAEELIELGA 301

Query: 300 REILAEVYNG 309
            +IL+E+  G
Sbjct: 302 NKILSELKEG 311


>UniRef50_Q30Y29 Porphobilinogen deaminase n=13 Tax=Bacteria RepID=HEM3_DESDG
          Length = 316

 Score =  393 bits (1010), Expect = e-108,   Method: Composition-based stats.
 Identities = 163/309 (52%), Positives = 206/309 (66%), Gaps = 2/309 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPG-LVVELVPMVTRGDVILDTPLAKVGGKGLF 62
             + IATR S LALWQA ++K+++M  +P    VEL+ + T+GD+ILD PLAKVGGKGLF
Sbjct: 2   KKIVIATRGSKLALWQAEHIKERIMQQYPDSFEVELLVLKTKGDIILDVPLAKVGGKGLF 61

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122
           VKE+E ALL+ RADIAVHSMKDVP+E PQGL L  I ERE P D+ +S  YD LDALP G
Sbjct: 62  VKEIEEALLDGRADIAVHSMKDVPMELPQGLTLGAIPEREVPTDSLLSARYDGLDALPQG 121

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           ++VGTSSLRRQ Q+   RPDL ++ LRGNV TR+ KL +GEYDAII+A +GLKRLG  + 
Sbjct: 122 AVVGTSSLRRQSQILAMRPDLEVKWLRGNVQTRIRKLMDGEYDAIIMATSGLKRLGETAP 181

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
             + L P + +PAVGQGA+G+E R D     E+LA L+H  + + V AER     L+GGC
Sbjct: 182 FHSELGPPLFMPAVGQGALGLEYRSDRQDLAEMLAFLDHRPSRICVEAERGFLFGLQGGC 241

Query: 243 QVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           QVPI  YA +       L  LV   DG+ +IR    G   DA   G++LA ++   GA  
Sbjct: 242 QVPIAGYAVMTGDNSFELTGLVAELDGTAVIRRTAAGTEADARDTGLTLAAQVKAAGADA 301

Query: 302 ILAEVYNGD 310
           IL  VY   
Sbjct: 302 ILQRVYENG 310


>UniRef50_Q4L709 Porphobilinogen deaminase n=88 Tax=Bacillales RepID=HEM3_STAHJ
          Length = 310

 Score =  391 bits (1005), Expect = e-107,   Method: Composition-based stats.
 Identities = 139/310 (44%), Positives = 196/310 (63%), Gaps = 4/310 (1%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             L + +R+S LAL Q+    DKL A  P L +E+  +VT+GD I++  L+KVGGKGLFV
Sbjct: 2   RKLVVGSRRSKLALTQSQQFIDKLKAVDPTLEIEIKEIVTKGDRIVNKQLSKVGGKGLFV 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KE++  L +   D+A+HS+KDVP   P+GL L  I +RE P DA++S N+  L+ LP GS
Sbjct: 62  KEIQQELFDKEIDMAIHSLKDVPSIIPEGLTLGCIPDREVPFDAYISKNHIPLNELPDGS 121

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           I+GTSSLRR  Q+  + P+L I+ +RGN+ TRL KL+  +YDAIILA AGL+R+G    I
Sbjct: 122 IIGTSSLRRGAQILSKYPNLEIKWIRGNIDTRLKKLEIEDYDAIILAAAGLRRMGWSDDI 181

Query: 184 -RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
               L  +I LPA+GQGA+GIECR DD    ELL+ +++   A  VTAER   + ++G C
Sbjct: 182 VTTYLDKDILLPAIGQGALGIECRSDDVELLELLSKVHNQAVANCVTAERTFLSAMDGSC 241

Query: 243 QVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           QVPIG YA    +GEI    L+  PDG++       G  ++   +G +++  L   GA E
Sbjct: 242 QVPIGGYATNKENGEIEFTGLIMTPDGTKRYEHTEVG--KNPVDLGEAVSRVLKEQGAYE 299

Query: 302 ILAEVYNGDA 311
           I+ ++    A
Sbjct: 300 IIKKLNEEQA 309


>UniRef50_B3QWI1 Porphobilinogen deaminase n=12 Tax=Chlorobiaceae RepID=HEM3_CHLT3
          Length = 314

 Score =  390 bits (1004), Expect = e-107,   Method: Composition-based stats.
 Identities = 144/314 (45%), Positives = 195/314 (62%), Gaps = 4/314 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   L I TR SPLALWQA ++K +L   +P L + L  + T GD ILD PLAK+G KGL
Sbjct: 1   MKKALIIGTRSSPLALWQAEFIKAELSKHYPSLDISLRHIKTTGDKILDAPLAKIGDKGL 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F +E+E  +L N  D+AVHS+KD+P E P+GL +  I ERED RD  +S    +L  LP 
Sbjct: 61  FTREIEHVMLRNEIDLAVHSLKDLPTETPEGLVITAITEREDNRDVLISKGKYTLKTLPQ 120

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+IV TSSLRR+ QL   RPDL +  +RGN+ TR  + + G+ +A++LA AG+ RL    
Sbjct: 121 GAIVATSSLRRRSQLLHLRPDLEVIDMRGNLNTRFKRFEEGDAEAMLLAFAGVHRLEFSE 180

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
            I   +  +  LPAVGQGA+GIE R+DD  TRELL  LNH ET L    ER++   LEGG
Sbjct: 181 HIAEIISFDDILPAVGQGALGIETRIDDEETRELLKVLNHAETELCTKCERSLLRTLEGG 240

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR----GAPQDAEQMGISLAEELLNN 297
           CQ+PIG++A + +G       VG+ DG + I+           ++AEQ+GI +A+     
Sbjct: 241 CQIPIGAHARIENGTFHFATYVGSIDGKRAIKKSLSRENVTTVEEAEQIGIEVADAARAA 300

Query: 298 GAREILAEVYNGDA 311
           GA EIL E+   +A
Sbjct: 301 GANEILCEIRTDNA 314


>UniRef50_C9R7U0 Porphobilinogen deaminase n=1 Tax=Ammonifex degensii KC4
           RepID=C9R7U0_AMMDK
          Length = 308

 Score =  390 bits (1002), Expect = e-107,   Method: Composition-based stats.
 Identities = 144/304 (47%), Positives = 186/304 (61%), Gaps = 3/304 (0%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
               LRI TR S LAL Q   V   L    P    E+V + T GD + +  L ++GGKGL
Sbjct: 4   SKRCLRIGTRGSDLALAQTEQVLQILRERWPHYTYEIVKIKTTGDKVRNLALPRIGGKGL 63

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F KELEVALLE + D+AVHS+KD+P E P+ L +  +  RE P D  +S     L+ LP 
Sbjct: 64  FTKELEVALLEEKIDLAVHSLKDLPTELPEELCVGAVLPREHPGDVLISLTGAGLEDLPE 123

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLK--RLGL 179
           G+ +GTSSLRRQ QL   RPDL    LRGNV TRL KL+ GE +A++LA AGL+  RL L
Sbjct: 124 GARIGTSSLRRQAQLKAARPDLNFVPLRGNVPTRLRKLEKGECEAVVLAWAGLRRLRLDL 183

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
             R+   LP ++ LPAV QGA+G+E R +D   R+++  L+   T L VTAERA    L 
Sbjct: 184 TGRMT-LLPYQVCLPAVAQGAIGVEMRKEDRELRKMVEVLDDPTTRLEVTAERAFLRWLG 242

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
           GGC VPI + A +   EI L  LV  P+G +I+RG+  G+    E++GI LAE LL  GA
Sbjct: 243 GGCHVPIAALARVAGAEILLEGLVADPEGKRIVRGQESGSTAYPEEVGIRLAERLLREGA 302

Query: 300 REIL 303
            E+L
Sbjct: 303 EELL 306


>UniRef50_B3E2H7 Porphobilinogen deaminase n=3 Tax=Proteobacteria RepID=HEM3_GEOLS
          Length = 312

 Score =  389 bits (1001), Expect = e-107,   Method: Composition-based stats.
 Identities = 161/310 (51%), Positives = 207/310 (66%), Gaps = 1/310 (0%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M    LRI TR S LALWQA++ K +L A +PG+ VELV + T GD ILD PLA+VGGKG
Sbjct: 1   MAPKRLRIGTRASQLALWQANWTKSELEARYPGIQVELVKIKTMGDKILDVPLAQVGGKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKE+E A+L    D+AVHSMKDVP EFP+GLGLV   +REDPRDAF+S +  +   L 
Sbjct: 61  LFVKEIEEAMLRGEIDLAVHSMKDVPTEFPEGLGLVVTTKREDPRDAFIS-DKVTFSELR 119

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ +GTS+LRRQ QL + RPDL +  +RGNV TR+ KL     DA+ILA AGL RLG  
Sbjct: 120 QGARIGTSALRRQAQLLKARPDLEMVIIRGNVETRIRKLKEDNLDAVILAAAGLNRLGFT 179

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
             +   L  + S+PA+GQGA+G+ECRLDD+ T E LA LNH +TA  V AERA+  R EG
Sbjct: 180 DVVTELLDTDFSIPAIGQGALGLECRLDDNATIEALAFLNHADTAAAVAAERALLKRCEG 239

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           GCQVPI ++  +    + L   + + DG Q +R    G+  DA ++G  LA+ LL  G +
Sbjct: 240 GCQVPIAAHGTVSGDTLTLVGFIASVDGKQTVRDRISGSTADAVKLGTELADRLLAAGGK 299

Query: 301 EILAEVYNGD 310
            IL +VY  +
Sbjct: 300 AILEDVYQRE 309


>UniRef50_Q54P93 Porphobilinogen deaminase n=1 Tax=Dictyostelium discoideum
           RepID=HEM3_DICDI
          Length = 325

 Score =  388 bits (997), Expect = e-106,   Method: Composition-based stats.
 Identities = 132/317 (41%), Positives = 191/317 (60%), Gaps = 12/317 (3%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            + I +R+S LA+ Q  +V+D++   +PG++VE+  M T GD +LD  L+K+G KGLF K
Sbjct: 9   KVIIGSRKSQLAMLQTEWVRDRIQELNPGIIVEIKTMDTTGDKVLDVSLSKIGDKGLFTK 68

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN-----NYDSLDAL 119
           ELE  +L    D+AVHS+KD+P + P GL L  I +R +  DAF++N         L  L
Sbjct: 69  ELEDMMLNGTIDLAVHSLKDIPTKLPDGLKLGAITKRYNTSDAFIANAKKHGKNCKLSEL 128

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--DNGEYDAIILAVAGLKRL 177
           P G+++G+SSLRR  QL +  P L  + +RGN+ TR  KL  D+  YD +ILAVAGL+R+
Sbjct: 129 PQGAMIGSSSLRRVAQLKKAYPHLQFKDIRGNLNTRFKKLEDDSNGYDGMILAVAGLERM 188

Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237
            L   I   +P  ISL AVGQG++GIEC+  D   + +L  L H E+     AER+M   
Sbjct: 189 ELTDHISEIIPDSISLYAVGQGSLGIECKDGDDFIQSILNPLIHRESMYCCEAERSMLRD 248

Query: 238 LEGGCQVPIGSYAELI-----DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAE 292
           LEGGC VPIG   +L      D  + + A+V   DGS+ I  +  G      Q+G S+A+
Sbjct: 249 LEGGCHVPIGVVTKLHNQSQPDETLEINAIVLNLDGSKYIESKIIGPSIQYYQLGKSIAQ 308

Query: 293 ELLNNGAREILAEVYNG 309
           +L+N G+++IL+E    
Sbjct: 309 DLINKGSKDILSEFIKK 325


>UniRef50_Q2LQU2 Porphobilinogen deaminase n=1 Tax=Syntrophus aciditrophicus SB
           RepID=HEM3_SYNAS
          Length = 306

 Score =  385 bits (989), Expect = e-105,   Method: Composition-based stats.
 Identities = 131/305 (42%), Positives = 186/305 (60%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           ++I TR S LAL Q   +  +L   +P + +E+V + T GD+  D PLAK+GGKGLF+KE
Sbjct: 1   MKIGTRGSALALTQTRQIAARLQGQYPEMHLEIVVIKTSGDIQKDVPLAKIGGKGLFIKE 60

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E ALL    D+AVHSMKD+P E P+GL +  +  REDPRD  +S      D LPAG+ +
Sbjct: 61  IEEALLAGTVDLAVHSMKDLPAELPEGLQIAAVPRREDPRDVLISGICREFDNLPAGARI 120

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GT SLRR  QL + RPDL I  LRGN+ TR+ K+     D +++A AG++R+G   ++  
Sbjct: 121 GTGSLRRSVQLRDWRPDLEIVPLRGNLDTRIRKVAQAALDGVVVAAAGIRRMGWAEKVTQ 180

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            +P E  LPAVGQG + +E R +D   +  LA L    T   VTAERA   RL GGC +P
Sbjct: 181 FIPTEKMLPAVGQGVLCLETREEDEDLKAGLAFLEDKRTRREVTAERAFLRRLGGGCTLP 240

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305
           + ++AE     + +R +VG+ +   +IR E  G+ + A  +G  LAE LL+ G R +L  
Sbjct: 241 VAAFAEQRGDVLTIRGMVGSLNERTMIRQEIYGSVEQAVDLGTELAERLLDGGGRILLEH 300

Query: 306 VYNGD 310
           + +G 
Sbjct: 301 LEDGQ 305


>UniRef50_A8PKX6 Porphobilinogen deaminase n=2 Tax=Gammaproteobacteria
           RepID=A8PKX6_9COXI
          Length = 311

 Score =  384 bits (986), Expect = e-105,   Method: Composition-based stats.
 Identities = 153/309 (49%), Positives = 194/309 (62%), Gaps = 3/309 (0%)

Query: 1   MLDNV-LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGK 59
           M     LRIATR+SPLA WQA  +K++L    P L + L+P VT GD      L + GGK
Sbjct: 1   MSKKKFLRIATRKSPLAYWQATSIKNQLEKIFPFLKITLLPFVTEGDR-PSHSLNQWGGK 59

Query: 60  GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119
           GLFVKELE ALL  +ADIAVHS+KD+P+   +GL L  IC+R DPRD  +S +      L
Sbjct: 60  GLFVKELEAALLHGQADIAVHSLKDLPMTLEKGLVLGAICKRCDPRDVLISRSDRLFTQL 119

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179
           P GS VGTSSLRRQ QL   RPDL I  LRGN+GTRL+KL  GE+DAIILA AGL RL  
Sbjct: 120 PPGSYVGTSSLRRQSQLLALRPDLKIGVLRGNIGTRLNKLAAGEFDAIILAAAGLIRLKK 179

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
              I      +  LPA GQGA+GIEC  +D  +   ++AL H  T   V AERA++  L 
Sbjct: 180 TECISEYFEIDHFLPAPGQGALGIECHENDEESLTYISALIHPITHSCVLAERALSRELG 239

Query: 240 GGCQVPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
           GGCQVP+ +YA  +    I L+A VG+ DG+  I+ E++G   +AE++G   A++L   G
Sbjct: 240 GGCQVPLAAYAASLGQDFIRLQAFVGSSDGTTQIKVEKQGPRVEAEKIGFLAAQDLRALG 299

Query: 299 AREILAEVY 307
             EIL +  
Sbjct: 300 VEEILNKFK 308


>UniRef50_A7NKU8 Porphobilinogen deaminase n=5 Tax=Bacteria RepID=HEM3_ROSCS
          Length = 303

 Score =  382 bits (983), Expect = e-105,   Method: Composition-based stats.
 Identities = 152/303 (50%), Positives = 195/303 (64%), Gaps = 1/303 (0%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           + N L I TR S LAL Q H ++D L A+HPGL V +  + TRGD+ILD PL  +G KGL
Sbjct: 1   MRNSLTIGTRASKLALVQTHMIRDALQAAHPGLTVAVERITTRGDIILDRPLNAIGDKGL 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FV E+E A+   R D+AVHS KD+P   P  + L     R DPRDA V+    +L +LP 
Sbjct: 61  FVVEIEEAMRAGRVDLAVHSAKDLPSTLPPDMTLAVCPRRADPRDALVAQPGMTLASLPH 120

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ VGTSSLRR CQL   RPDL +  LRGNV TRL KL  G+YDAI+LA AGLKRLGLE 
Sbjct: 121 GARVGTSSLRRACQLRALRPDLTLLDLRGNVDTRLRKLREGQYDAIVLAAAGLKRLGLEE 180

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
            I   L P++ +PAVGQG +G+E R  D     LLA L+       +TAERA   R+ GG
Sbjct: 181 VITELLEPDVLIPAVGQGIIGVEARAGDDEVLRLLAPLDDPAARAAITAERAFLARIGGG 240

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           C+VP+G+ A L   E+ L  ++GA DG +++RG R G+  D   +G +LAEELL+ G + 
Sbjct: 241 CRVPVGALALLEGDELLLYGMIGALDG-RMVRGMRSGSASDPAGLGSALAEELLDAGGQA 299

Query: 302 ILA 304
           +LA
Sbjct: 300 LLA 302


>UniRef50_A3ETN3 Porphobilinogen deaminase n=2 Tax=Leptospirillum sp. Group II
           RepID=A3ETN3_9BACT
          Length = 314

 Score =  382 bits (982), Expect = e-105,   Method: Composition-based stats.
 Identities = 149/315 (47%), Positives = 191/315 (60%), Gaps = 5/315 (1%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           ML   L+I +R S LALWQA +V   + +   G++ E+V + T GD+ILD  L++VGGKG
Sbjct: 1   MLPTPLKIGSRGSELALWQARHVASLIESVS-GVLPEIVVIKTTGDIILDRQLSEVGGKG 59

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKE+E ALL    D+AVHSMKDVP   P GL L     REDPRD F+S +Y  + +LP
Sbjct: 60  LFVKEIEEALLRKEIDLAVHSMKDVPAFLPPGLTLAATLTREDPRDVFLSPHYPDIKSLP 119

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
             + VGTSSLRR  Q+ E R DL    LRGNVGTR+ K++ G  DAIILA AGL RLG  
Sbjct: 120 QKARVGTSSLRRLAQIREIRNDLEFIPLRGNVGTRIRKMEEGVVDAIILAGAGLLRLGHA 179

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
           +R+R  + P + LPA+GQGA+G+E R DD  T  L+ +L+   T L V AER +   L G
Sbjct: 180 NRVREWISPRVLLPAIGQGALGLEIRTDDETTGTLVRSLSDESTHLSVAAERGVLQSLNG 239

Query: 241 GCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERR---GAPQDAEQMGISLAEELLN 296
           GCQVPI +YA       + L   V    G++ I            DA QMGI L   LL+
Sbjct: 240 GCQVPIAAYAVWEKNRTLSLEGRVLDISGTRRIHARETRDIVTIDDAYQMGIDLGNRLLS 299

Query: 297 NGAREILAEVYNGDA 311
           +GA EIL  +    +
Sbjct: 300 DGAEEILNSILKKSS 314


>UniRef50_Q1J288 Porphobilinogen deaminase n=5 Tax=Deinococci RepID=HEM3_DEIGD
          Length = 309

 Score =  382 bits (981), Expect = e-104,   Method: Composition-based stats.
 Identities = 130/304 (42%), Positives = 181/304 (59%), Gaps = 3/304 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILD--TPLAKVGGKGL 61
             + + TR S LAL Q  +V  +L    P     +  + T+GD        LA+ G KG 
Sbjct: 2   RTVTVGTRGSALALAQTRWVVARLKEEWPDTDFRIQTISTKGDRDRAALQSLAQKGDKGF 61

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALP 120
           +VKE+E ALL  R DIAVHS+KD+P E P+GL + +I +R D RD  +  +    L+ LP
Sbjct: 62  WVKEIEDALLAGRIDIAVHSLKDLPTEQPEGLEIASIPKRVDARDVLIGKDGMKRLEDLP 121

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
           +G+ VGTSS+RR+  L   RPDL I  LRGN+ TRL+ L   +YDAI+LA AGL R  + 
Sbjct: 122 SGARVGTSSVRRKAFLRAYRPDLQILDLRGNIDTRLAALGTPDYDAIVLAAAGLIRTEMR 181

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            RI   + P++ LPA GQGA+ +E R DD  + E++ A++ H T  RVTAER     L  
Sbjct: 182 HRIDEFIDPDLLLPAPGQGALALETRADDDLSIEVVYAIHDHATDDRVTAEREFLAGLGA 241

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
           GC  P+G++A L DG + L   VGA DGSQ+IR    G P +   +G  LA ++L  GA+
Sbjct: 242 GCMAPVGAHATLKDGVLTLEGWVGALDGSQVIRATTSGDPAECADLGAELAADMLGQGAQ 301

Query: 301 EILA 304
           +++ 
Sbjct: 302 QLIE 305


>UniRef50_Q180R9 Porphobilinogen deaminase n=11 Tax=Bacteria RepID=HEM3_CLOD6
          Length = 301

 Score =  380 bits (976), Expect = e-104,   Method: Composition-based stats.
 Identities = 110/293 (37%), Positives = 171/293 (58%), Gaps = 1/293 (0%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           + + TR S LAL Q  +V ++L   +P +  E+  + T+GD+I +  L K+G KGLFVKE
Sbjct: 3   IVVGTRGSNLALIQTEWVINELKKKYPEISFEIKIIKTKGDLIQNVSLDKIGDKGLFVKE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS-LDALPAGSI 124
           +E  LL+ + DIAVHSMKD+P     GL      +REDPRD  +       LD LP G++
Sbjct: 63  IEQQLLDGKIDIAVHSMKDMPSYLANGLKFAHTPKREDPRDVLILREGYKNLDDLPHGAV 122

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GT S RR+ QL ++RPDL I  +RGNV TR+ K+ +     I+LA +G+ R  L+ +I 
Sbjct: 123 IGTGSKRRKFQLLKQRPDLNIVQVRGNVETRIRKIKDENMHGIVLAASGIIRANLQDKIS 182

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
           + LP ++ +PA  QGA+ IE R +DS    ++ +L    T +++ AER     + G C +
Sbjct: 183 SYLPVDVVIPAPAQGALAIEIRSNDSAIEGIVNSLKDENTEIQILAERGFLDGVNGSCHI 242

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           P+ +Y E+I  +I L  L G  +G +++     G      ++G+ LA+ +L  
Sbjct: 243 PMAAYCEIIQDKIHLTGLYGDSEGKKVVIKSIDGDISSPRELGLKLAKLVLKE 295


>UniRef50_A6WXJ2 Porphobilinogen deaminase n=56 Tax=cellular organisms
           RepID=HEM3_OCHA4
          Length = 314

 Score =  380 bits (976), Expect = e-104,   Method: Composition-based stats.
 Identities = 132/306 (43%), Positives = 174/306 (56%), Gaps = 2/306 (0%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGG 58
           + +  L+I TR S LAL QA+  + +LM +H  P   +E++PM T GD I D  L+++GG
Sbjct: 6   LKNGTLKIGTRGSKLALAQAYETRRRLMEAHGLPEEAIEIIPMSTAGDRIQDRALSEIGG 65

Query: 59  KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118
           KGLF +E+E AL + R D+AVHS KD+P   P GL L    EREDPRDAF+      L  
Sbjct: 66  KGLFTEEIEQALTDGRIDLAVHSTKDMPTVLPDGLHLSVFLEREDPRDAFIGRTASRLLD 125

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178
           LP G+ VG+SSLRRQ  +   RPD+ +   RGNV TRL KL+ GE D   LA AGL+RLG
Sbjct: 126 LPQGATVGSSSLRRQALIRRLRPDIQVVIFRGNVDTRLRKLEAGEVDGTFLACAGLRRLG 185

Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
           L   I     PE   PA GQGA+GIE R+ D+R   LLA L H ET + +  ERA    L
Sbjct: 186 LGDVITDLADPESFPPAPGQGAIGIETRIGDTRIDTLLAPLAHRETGIALACERAFLAAL 245

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
           +G C+ PI   A +    +    ++  PDGS+    +  G   +A  +G   AE L    
Sbjct: 246 DGSCRTPIAGLATVNGDTVSFHGMILKPDGSEAHEIKTEGPASNAAAIGTEAAEHLRAKA 305

Query: 299 AREILA 304
             +   
Sbjct: 306 GPQFFE 311


>UniRef50_B6FXV9 Putative uncharacterized protein n=1 Tax=Clostridium hiranonis DSM
           13275 RepID=B6FXV9_9CLOT
          Length = 299

 Score =  379 bits (975), Expect = e-104,   Method: Composition-based stats.
 Identities = 113/298 (37%), Positives = 176/298 (59%), Gaps = 1/298 (0%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            +R+ TR S LAL Q ++  D+L    P +  E+  + T+GD IL   L K+G KGLFVK
Sbjct: 2   KIRVGTRGSNLALIQTNWAIDRLKEKFPEVEFEVKIIKTKGDKILHLSLDKIGDKGLFVK 61

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALPAGS 123
           E+E  LLE   D+AVHSMKD+P E  +GL    + +REDPRD  +     +S D LP G+
Sbjct: 62  EIESQLLEGEIDLAVHSMKDMPAEVVEGLKFAAVPKREDPRDVIILREGLNSFDELPIGA 121

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            +GT S RR+ QL  +RPDL I  +RGN+ TR+SK+++   D I+LA +G+ R  LE +I
Sbjct: 122 TIGTGSKRRKYQLLRKRPDLNIVPIRGNIETRISKIESENLDGIVLAASGVIRADLEEKI 181

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              LP ++ +PA  QGA+ +E R +D    +++ A+    + ++  AER+    ++G C 
Sbjct: 182 TEFLPVDLMIPAPAQGALALEIRENDEELEKMIDAIKDEISQIQTDAERSYLAGIDGSCH 241

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           +P+G+Y E+   ++ L  + G  DG +I      G   + +++G +LA+ +L     E
Sbjct: 242 IPMGAYCEVDGEKLTLTGIFGDEDGEKITVASLEGDRDNPKELGSNLAKLVLKKHREE 299


>UniRef50_B2S842 Porphobilinogen deaminase n=38 Tax=Rhizobiales RepID=HEM3_BRUA1
          Length = 314

 Score =  377 bits (970), Expect = e-103,   Method: Composition-based stats.
 Identities = 134/305 (43%), Positives = 170/305 (55%), Gaps = 2/305 (0%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGK 59
            +  L+I TR S LAL QA+  +  L  +H  P   +E++PM T GD I D PL++VGGK
Sbjct: 7   KNGTLKIGTRGSKLALAQAYLTRRLLQEAHGLPEDAIEILPMSTAGDRIQDRPLSEVGGK 66

Query: 60  GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119
           GLF +E+E AL + R DIAVHS KD+P   P+GL L    EREDPRDAF+  +      L
Sbjct: 67  GLFTEEIEQALKDGRIDIAVHSTKDMPTALPEGLHLSVFLEREDPRDAFIGRSARRFMDL 126

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179
           P G+ VG+SSLRRQ  +   RPD+ +   RGNV TRL KLD GE D   LA AGL+RLGL
Sbjct: 127 PQGATVGSSSLRRQALIRRLRPDIEVVMYRGNVDTRLRKLDAGEVDGTFLACAGLRRLGL 186

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
              I   L P +  PA GQGA+GIE R+ D R   LLA L H ET + +  ERA    L+
Sbjct: 187 ADVITDVLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERAFLGALD 246

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
           G C+ PI   A +    +  R ++  PDG Q       G   DA  +G   A  +     
Sbjct: 247 GSCRTPIAGLATVEGDRLSFRGMILTPDGRQAHEVTAEGVVSDAAALGTDAANRVRAMAG 306

Query: 300 REILA 304
                
Sbjct: 307 PHFFD 311


>UniRef50_A7GYU4 Porphobilinogen deaminase n=34 Tax=Campylobacterales
           RepID=HEM3_CAMC5
          Length = 311

 Score =  377 bits (970), Expect = e-103,   Method: Composition-based stats.
 Identities = 160/307 (52%), Positives = 200/307 (65%), Gaps = 3/307 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
            +L+IATR+S LALWQ+ ++K +LMA H GL VELV M T+GDVILDTPLAK+GGKGLF 
Sbjct: 2   KILKIATRKSALALWQSEHIKARLMAQHAGLQVELVGMKTKGDVILDTPLAKIGGKGLFT 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KELE ++L  +  IAVHS+KDVPV F  GL L  IC RED RDA +S  Y   D LP  +
Sbjct: 62  KELEDSMLSGQTHIAVHSLKDVPVAFLDGLVLAAICSREDVRDAMISQRYVKFDDLPQSA 121

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            VGT+SLRR+ QL   RPDL I SLRGNV TRL KL  GE+DAIILA+AG+ RL L   +
Sbjct: 122 KVGTTSLRRKMQLLRMRPDLNIISLRGNVQTRLRKLKEGEFDAIILAMAGINRLNLADEV 181

Query: 184 RAALPPEI--SLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
               P +I    PA+GQGA+G+E  +DD++  E +  LN   + +    ER   T LEGG
Sbjct: 182 AHIYPFDIAQMTPAMGQGALGVEA-VDDAQILEKIKFLNDERSVIETRVERDFVTLLEGG 240

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           CQVPIG  A L   EI + A+VG PDGS++I         + E +G  LA E +  GA+E
Sbjct: 241 CQVPIGINARLASEEIEINAIVGLPDGSEVITENLTAKKSEFESVGKELAREFIARGAKE 300

Query: 302 ILAEVYN 308
           +L     
Sbjct: 301 LLKRAEE 307


>UniRef50_O94048 Porphobilinogen deaminase n=53 Tax=Saccharomyceta RepID=HEM3_CANAL
          Length = 340

 Score =  375 bits (965), Expect = e-103,   Method: Composition-based stats.
 Identities = 129/319 (40%), Positives = 185/319 (57%), Gaps = 17/319 (5%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62
            N ++I  R+S LA+ Q+  VK  +  + P L   ++ + T GD +   PL   GGK L+
Sbjct: 11  SNHVQIGGRKSKLAVVQSEIVKKVIEDTFPNLSCSILALSTLGDKVQTQPLYTFGGKSLW 70

Query: 63  VKELEVALLEN-----RADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---D 114
            KELE+ LL++     + D+ VHS+KD+P   P+   L  I +REDPRDA V        
Sbjct: 71  TKELEILLLDSVDEFPKLDLIVHSLKDMPTNLPEEFELGCIFQREDPRDAIVMKQGSSYK 130

Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVA 172
           SL  LPAG+IVGTSS+RR  QL +  P L   S+RGN+ TRL+KLD  N EY  +ILA A
Sbjct: 131 SLKDLPAGAIVGTSSIRRSSQLIKNYPHLRFESVRGNIQTRLNKLDQPNNEYCCLILASA 190

Query: 173 GLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232
           GL RLGL  RI + L  +    AVGQGA+GIE R  D   + +L  +      +   AER
Sbjct: 191 GLIRLGLGHRITSYL--DDMYYAVGQGALGIEIRKGDDNIKSILKKIEDPIATICCLAER 248

Query: 233 AMNTRLEGGCQVPIGSYAELIDGE--IWLRALVGAPDGSQIIRGER---RGAPQDAEQMG 287
           ++   LEGGC VP+G +++  + +  + L+ ++ +PDG+  I  E        +D EQ+G
Sbjct: 249 SLMRYLEGGCSVPLGVHSDYNESKQELTLKGIIVSPDGTVSIEDEVIKRITCDEDCEQVG 308

Query: 288 ISLAEELLNNGAREILAEV 306
           I L ++L   GA+EIL ++
Sbjct: 309 IELGDKLKAKGAKEILDKI 327


>UniRef50_A6Q7Y4 Porphobilinogen deaminase n=7 Tax=Epsilonproteobacteria
           RepID=HEM3_SULNB
          Length = 323

 Score =  375 bits (963), Expect = e-102,   Method: Composition-based stats.
 Identities = 137/319 (42%), Positives = 191/319 (59%), Gaps = 10/319 (3%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             L IATR S LALWQA+++K+++  + P + VEL  + ++GD ILD PLA VGGKG F 
Sbjct: 2   EKLVIATRASNLALWQAYHIKERIETAFPEVRVELNEITSKGDKILDKPLALVGGKGHFT 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KELE  ++   A +AVHS+KDVP   P+GL L  I ER+D  D F+S+ Y SL  LP G+
Sbjct: 62  KELEDEMIAGNAHLAVHSLKDVPTYIPEGLELCAITERQDQSDVFLSHTYKSLSELPEGA 121

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           +VGT+SLRR+ QL E+RPDL ++ LRGNV TRL KL  G+YDAIILA  GL RL L   I
Sbjct: 122 VVGTTSLRRRMQLLEKRPDLKVKDLRGNVNTRLRKLKEGQYDAIILAYIGLYRLDLLKDI 181

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
                 +  +P +GQ A+GIE   ++ R RE+   LNH  T +    ER   + +  GC 
Sbjct: 182 PYVEKLDFFIPPMGQAALGIEIVANNDRIREIAMTLNHEPTFICTKVERDFISVIGAGCS 241

Query: 244 VPIGSYAELIDGE------IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
            P+   A +   E      I +RA++G PDG+ I+         +A+ +G  LA+ ++  
Sbjct: 242 APVAVNATMDKKEDDKVPTISVRAMIGYPDGTHILHKSLTVPLNEADILGDELAQAMIEE 301

Query: 298 GAREILAE----VYNGDAP 312
           GA +IL +     +  + P
Sbjct: 302 GALDILEQAEIIAFKDEMP 320


>UniRef50_D0LUE1 Porphobilinogen deaminase n=1 Tax=Haliangium ochraceum DSM 14365
           RepID=D0LUE1_HALO1
          Length = 320

 Score =  373 bits (959), Expect = e-102,   Method: Composition-based stats.
 Identities = 156/315 (49%), Positives = 196/315 (62%), Gaps = 11/315 (3%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M +  + I+TR S LALWQAH+V+D++    P   VELV + T+GD ILD PL+K+GGK 
Sbjct: 1   MSERTIHISTRGSQLALWQAHHVRDEIRRVRPAWQVELVIIKTQGDKILDVPLSKIGGKA 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LFVKE+E ALL+ RAD+AVHSMKDVP E   GL +     REDP DA  + +   LD L 
Sbjct: 61  LFVKEIEQALLDGRADVAVHSMKDVPAELAPGLFMAATSRREDPYDALCTRDGRGLDELA 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ +GTSSLRRQCQ+  RRPDL I  LRGNV TRL KLD+G +DA+ILA AGLKRLG  
Sbjct: 121 EGATLGTSSLRRQCQILARRPDLRIEMLRGNVPTRLGKLDDGSFDAVILAAAGLKRLGHG 180

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDD-----SRTRELLAALNHHETALRVTAERAMN 235
            RI   L   + +PAVGQG +GIE R  D          L  AL+      RV AERAM 
Sbjct: 181 ERISQRLDGGVCVPAVGQGVLGIETRQGDAPADRELVEALREALHDPAEERRVVAERAMM 240

Query: 236 TRLEGGCQVPIGSYAELIDG------EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGIS 289
             L G CQ P+ ++A            + +  L G PDGS+I+R +  G  +DA+ +G S
Sbjct: 241 AALGGSCQTPLAAHASYRGDSDPVAGTLVIEGLCGRPDGSEILRAQVEGRAEDAQALGSS 300

Query: 290 LAEELLNNGAREILA 304
           LAEEL   GA+ I+ 
Sbjct: 301 LAEELRGQGAQAIID 315


>UniRef50_Q43316 Porphobilinogen deaminase, chloroplastic n=61 Tax=cellular
           organisms RepID=HEM3_ARATH
          Length = 382

 Score =  372 bits (957), Expect = e-102,   Method: Composition-based stats.
 Identities = 137/303 (45%), Positives = 185/303 (61%), Gaps = 8/303 (2%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGL----VVELVPMVTRGDVILDTPLAKVGGKG 60
           ++RI TR SPLAL QA+  ++KL   HP L     + +  + T GD IL  PLA +GGKG
Sbjct: 74  IIRIGTRGSPLALAQAYETREKLKKKHPELVEDGAIHIEIIKTTGDKILSQPLADIGGKG 133

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LF KE++ AL+    DIAVHSMKDVP   P+   L     RED RDAF+     +L  LP
Sbjct: 134 LFTKEIDEALINGHIDIAVHSMKDVPTYLPEKTILPCNLPREDVRDAFICLTAATLAELP 193

Query: 121 AGSIVGTSSLRRQCQLAERRPDLII-RSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179
           AGS+VGT+SLRR+ Q+  + P L +  + RGNV TRLSKL  G+  A +LA+AGLKRL +
Sbjct: 194 AGSVVGTASLRRKSQILHKYPALHVEENFRGNVQTRLSKLQGGKVQATLLALAGLKRLSM 253

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
              + + L  +  LPAV QGA+GI CR DD +    LA+LNH ET L ++ ERA    L+
Sbjct: 254 TENVASILSLDEMLPAVAQGAIGIACRTDDDKMATYLASLNHEETRLAISCERAFLETLD 313

Query: 240 GGCQVPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGA--PQDAEQMGISLAEELLN 296
           G C+ PI  YA +  +G    R LV +PDG++++   R+G    +D  +MG    +ELL+
Sbjct: 314 GSCRTPIAGYASKDEEGNCIFRGLVASPDGTKVLETSRKGPYVYEDMVKMGKDAGQELLS 373

Query: 297 NGA 299
              
Sbjct: 374 RAG 376


>UniRef50_D2R3S6 Porphobilinogen deaminase n=2 Tax=Planctomycetaceae
           RepID=D2R3S6_9PLAN
          Length = 311

 Score =  372 bits (957), Expect = e-102,   Method: Composition-based stats.
 Identities = 144/303 (47%), Positives = 192/303 (63%), Gaps = 2/303 (0%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            LR+ TR SPLA WQA +V+D+L+A+  G+ VE++ + T GD     PL ++GG+GLF K
Sbjct: 6   KLRLGTRASPLARWQADWVRDQLIAA--GIDVEMILITTEGDQQTSQPLGQIGGQGLFTK 63

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           E++  LL    D+AVHS+KD+P     GL L  + ERED  D  +     SL  LP+G+ 
Sbjct: 64  EIQRRLLAGDIDLAVHSLKDLPTLPIDGLSLAAVPEREDTADILIGPAGTSLATLPSGAK 123

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GT SLRR+ QL   R DL I  +RGNV TRL KLD G+Y AIILA AGLKRL L+ R+ 
Sbjct: 124 IGTGSLRRKAQLLHARADLEILDIRGNVDTRLRKLDEGQYHAIILAAAGLKRLKLDDRMT 183

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L   + LPAVGQGA+GIE R DD  TR+LLA L+H  T   V AER++   L  GC  
Sbjct: 184 ERLEAPLMLPAVGQGALGIESRSDDPTTRKLLAPLSHAPTLQAVIAERSLLAALRAGCLA 243

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304
           P+G++A+++DG++ L A+V + DG   +      AP DA Q+G  +AE L   GA E+LA
Sbjct: 244 PVGAHAQVVDGQLTLAAVVLSIDGQSRLFASLTSAPADAAQLGEEVAELLRQQGATELLA 303

Query: 305 EVY 307
              
Sbjct: 304 SSR 306


>UniRef50_P28789 Porphobilinogen deaminase n=18 Tax=Saccharomycetales
           RepID=HEM3_YEAST
          Length = 327

 Score =  371 bits (954), Expect = e-101,   Method: Composition-based stats.
 Identities = 123/322 (38%), Positives = 177/322 (54%), Gaps = 15/322 (4%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M    L I  R+S LA+ Q+++V   +   +P    ++  + T GD I   PL   GGK 
Sbjct: 1   MGPETLHIGGRKSKLAVIQSNHVLKLIEEKYPDYDCKVFTLQTLGDQIQFKPLYSFGGKA 60

Query: 61  LFVKELEVALL----ENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NY 113
           L+ KELE  L       + D+ VHS+KD+P   P+G  L  I +R DP D  V      Y
Sbjct: 61  LWTKELEDHLYHDDPSKKLDLIVHSLKDMPTLLPEGFELGGITKRVDPTDCLVMPFYSAY 120

Query: 114 DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAV 171
            SLD LP G IVGTSS+RR  QL  + P L   S+RGN+ TRL KLD+ +  Y  IILA 
Sbjct: 121 KSLDDLPDGGIVGTSSVRRSAQLKRKYPHLKFESVRGNIQTRLQKLDDPKSPYQCIILAS 180

Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231
           AGL R+GLE+RI      +    AVGQGA+GIE R  D++  ++L  +      +   +E
Sbjct: 181 AGLMRMGLENRITQRFHSDTMYHAVGQGALGIEIRKGDTKMMKILDEICDLNATICCLSE 240

Query: 232 RAMNTRLEGGCQVPIGSYAELIDG--EIWLRALVGAPDGSQIIRGE----RRGAPQDAEQ 285
           RA+   LEGGC VPIG  ++  +   ++ L+A+V   +G++ +  E         +D+  
Sbjct: 241 RALMRTLEGGCSVPIGVESKYNEETKKLLLKAIVVDVEGTEAVEDEIEMLIENVKEDSMA 300

Query: 286 MGISLAEELLNNGAREILAEVY 307
            G  LAE ++ +GA++IL E+ 
Sbjct: 301 CGKILAERMIADGAKKILDEIN 322


>UniRef50_A5VM67 Porphobilinogen deaminase n=9 Tax=Lactobacillus RepID=HEM3_LACRD
          Length = 305

 Score =  370 bits (952), Expect = e-101,   Method: Composition-based stats.
 Identities = 118/298 (39%), Positives = 167/298 (56%), Gaps = 4/298 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           + N + + +R+S LA+ Q   V   L    P +  E+  ++T GD      LAK+GGKG+
Sbjct: 1   MTNKVIVGSRKSKLAMAQTELVIASLEKIFPDIKFEIKNVITEGDRNRHVSLAKIGGKGV 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALP 120
           FVKE+E  L +   D AVHS+KDV    P+ L L    +R  P D  VS     SL+ LP
Sbjct: 61  FVKEIEDELKDGTIDFAVHSLKDVMPILPEELVLGAFPKRVSPYDCLVSRKNLSSLNDLP 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ +GT+SLRRQ QL   RPDL I  +RGN+ TRL K+D    D IILA AGL RL ++
Sbjct: 121 KGARIGTNSLRRQGQLLSIRPDLKIIPIRGNIDTRLRKIDTEALDGIILAEAGLTRLNID 180

Query: 181 SRIRAALPPE-ISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
                 L  +   +PAVGQG + IECR +D+R R++L  +N  E+A  V  ER     L 
Sbjct: 181 LSSYHVLDLQNYIMPAVGQGCLAIECRKNDTRIRKMLDQINDEESAYCVQVEREFMRELG 240

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           G C  PIG +A   +G+I    L+ +P+G  +I+  +   P +   +G  +A++LL  
Sbjct: 241 GSCNFPIGGHAYAKNGQILFDGLIASPNGEHVIKETKI--PANNSGVGKKVADQLLAK 296


>UniRef50_Q8RFP5 Porphobilinogen deaminase n=16 Tax=Fusobacteriaceae
           RepID=HEM3_FUSNN
          Length = 298

 Score =  370 bits (950), Expect = e-101,   Method: Composition-based stats.
 Identities = 119/298 (39%), Positives = 166/298 (55%), Gaps = 5/298 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPL--AKVGGK 59
           +   + I +R S LAL QA+ VKD+L  ++P L  E+  +VT GD  L +    + +  K
Sbjct: 1   MKKNIIIGSRGSILALAQANLVKDRLQGNYPNLSFEIKEIVTSGDKDLKSNWENSDISLK 60

Query: 60  GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119
             F KE+E  LL+   DIAVHSMKD+P    + L    I +REDPRD  VS N   L  L
Sbjct: 61  SFFTKEIEQELLDGEIDIAVHSMKDMPAVSAKSLICGAIPDREDPRDVLVSKNGL-LVTL 119

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179
           P G+ VGTSSLRR   L   RPD  I+ LRGN+ TRL KL+  +YDAI+LA AGLKR GL
Sbjct: 120 PQGAKVGTSSLRRAMNLKTVRPDFEIKHLRGNIHTRLKKLETEDYDAIVLAAAGLKRTGL 179

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
             +I   L  E+  PA  QG + I+CR +D   +E+L ++++   A  V  ER  +   +
Sbjct: 180 ADKITEYLNGEVFPPAPAQGVLYIQCRENDEEIKEILKSIHNEAIAKIVEIEREFSKIFD 239

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           GGC  P+G Y+++   +I   A+    D  + IR          +++    AEE+ N 
Sbjct: 240 GGCHTPMGCYSQVNGDKIKFTAVY--LDEGKQIRAVVEDDLAKGKEIAYMAAEEIKNK 295


>UniRef50_UPI0001926E0E PREDICTED: similar to hydroxymethylbilane synthase, partial n=1
           Tax=Hydra magnipapillata RepID=UPI0001926E0E
          Length = 418

 Score =  369 bits (948), Expect = e-101,   Method: Composition-based stats.
 Identities = 123/342 (35%), Positives = 167/342 (48%), Gaps = 35/342 (10%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62
              + + +R+S LA+ Q   +   L      +   +  M T GD IL   L K+G K LF
Sbjct: 28  KTSVVVGSRKSQLAVIQTKSIVAALCQKEKDVECIIETMDTLGDKILHIALPKIGEKSLF 87

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDAL 119
            K+LE+AL E R D  VHS+KD+P   PQG+ + TI +R+DPRD  + +   N   L  L
Sbjct: 88  TKDLELALSEKRVDFLVHSLKDLPTTLPQGMAISTIYKRDDPRDCIIFHPKHNGKKLADL 147

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-YDAIILAVAGLKRLG 178
           P  SI+GTSSLRR  QL  +   L  +S+RGN+ TRL KL+    YDAI+LA AG+ R+G
Sbjct: 148 PENSIIGTSSLRRVAQLKRKYNKLTFQSVRGNLNTRLQKLEEESLYDAIVLAKAGVDRMG 207

Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
              +I   L  +  L A+GQGA+ +E R DD  T  +LA L   ET L   AER     L
Sbjct: 208 WTEKIGQILSEDECLYAIGQGAITVEVRNDDKYTISILAQLTDMETLLACVAERCFMRTL 267

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ----------------- 281
            GGC  PI  +++       LR +V   DGS+ +        Q                 
Sbjct: 268 NGGCSTPIACHSQFSGNNYSLRGIVLNADGSRFLDSTVSTTLQVNILTDQNEPPSYTVSK 327

Query: 282 --------------DAEQMGISLAEELLNNGAREILAEVYNG 309
                          AE+ G  LA  L   GA ++L EV + 
Sbjct: 328 SGVVINSLYINEFIKAEKCGEELAYCLKKLGADDVLKEVRSK 369


>UniRef50_C8WXM9 Porphobilinogen deaminase n=2 Tax=Alicyclobacillus acidocaldarius
           RepID=C8WXM9_ALIAD
          Length = 305

 Score =  369 bits (947), Expect = e-101,   Method: Composition-based stats.
 Identities = 151/301 (50%), Positives = 196/301 (65%), Gaps = 2/301 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             LR+ATR+S LAL Q ++V D L     G+  ELVP+ TRGD I+D  L++VGGKGLFV
Sbjct: 2   RTLRVATRRSALALTQTNHVVDLLKQVAHGVEFELVPIRTRGDEIVDRALSEVGGKGLFV 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
            ++E AL   +AD+AVHS+KDVP E   GL +  +  REDPRDA +S     L  LP G+
Sbjct: 62  ADIEDALATGQADLAVHSLKDVPFELRDGLTIGAVPPREDPRDALISRTGQGLFDLPPGA 121

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            VGTSSLRRQ  L   RPDL + +LRGNV TRL +L+ G++DAI+LA +GL RLGL  RI
Sbjct: 122 RVGTSSLRRQAALRRLRPDLCVETLRGNVDTRLRRLEEGQFDAIVLAASGLHRLGLAERI 181

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              LP +  +PAVGQGA+ IECR +D      LAA+   +    V AERA  +RLEG CQ
Sbjct: 182 TEYLPVDRFVPAVGQGALAIECRAEDDEVMRHLAAIADPDATRAVEAERAFLSRLEGSCQ 241

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           VPIG+YAE +  E+ L A V  P G   ++ ER G   +A  +G+++AEE+L  GA + L
Sbjct: 242 VPIGAYAEPVGHELRLIAFVADPSGIHHLQLERTG--DEARALGVAMAEEMLRQGAEDWL 299

Query: 304 A 304
            
Sbjct: 300 K 300


>UniRef50_B3T8H9 Putative Porphobilinogen deaminase, dipyromethane cofactor binding
           domain protein n=1 Tax=uncultured marine microorganism
           HF4000_APKG5H11 RepID=B3T8H9_9ZZZZ
          Length = 322

 Score =  369 bits (947), Expect = e-100,   Method: Composition-based stats.
 Identities = 122/306 (39%), Positives = 171/306 (55%), Gaps = 1/306 (0%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +++ +R S LAL Q H V ++L A+ P L  E+  + TRGDV   + LA +G  G+FVKE
Sbjct: 18  IKVGSRGSTLALIQDHVVINRLKANSPALEFEVDTVRTRGDVDQTSRLAGMG-LGIFVKE 76

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           LE  LL+ + DIAVHS+KD+P +   GL L  +  REDPRD  V+     LD LP G+ +
Sbjct: 77  LEQELLDGKLDIAVHSLKDMPTQLADGLVLGAVLSREDPRDVLVNRYGCPLDGLPKGAKI 136

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS RR  QL +  P + + S+RGNV TRL K    E D  ILA AG+ RLGL+ +I  
Sbjct: 137 GTSSPRRAAQLKQYAPQVEVVSIRGNVETRLRKAQGEEADGAILAAAGMIRLGLQDQIAE 196

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L     +P  GQG + +E R DD R  ELL+A++  +T    TAER    RL GGC +P
Sbjct: 197 YLSATQFVPPPGQGILAVEARADDFRMLELLSAIDDADTRYEATAERGFLARLGGGCSIP 256

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAE 305
           +G+YA      I +   +   DG +    + +G  +D  Q+       L+  G  +++A 
Sbjct: 257 VGAYARCNGDNIVMTIYMSTADGEKKFSAKIQGLKRDPLQLANDAYLALVERGGADLVAA 316

Query: 306 VYNGDA 311
                A
Sbjct: 317 ARANQA 322


>UniRef50_A9A1A1 Probable porphobilinogen deaminase n=3 Tax=Thaumarchaeota
           RepID=HEM3_NITMS
          Length = 311

 Score =  369 bits (947), Expect = e-100,   Method: Composition-based stats.
 Identities = 107/298 (35%), Positives = 171/298 (57%), Gaps = 2/298 (0%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
              +  R S L++ Q + V  +L  +HP    E+  + T+GD     PL  +  KG+F K
Sbjct: 2   KYIVGARGSQLSVAQTNLVIAELKKAHPDTEYEIKTITTKGDTD-SRPLFTIDQKGIFEK 60

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           E++ A+ +   D AVHS+KDVP E    L L  I +RE   D F+S +  +LD++  GS+
Sbjct: 61  EIDRAVAQKEVDFAVHSLKDVPSELDDNLVLACIPKRETVNDVFISPDGSTLDSIKPGSV 120

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GTSSLRR  Q++ +RPD+ ++ +RGN+ TR+ K     YDAI+LA AG+ RLG++ +  
Sbjct: 121 IGTSSLRRAVQVSRKRPDVTVKPIRGNIETRIKKASGENYDAIVLAKAGISRLGVDVKYT 180

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L  +   P+ GQGA+ I  R DDS+T E+L  +   ++ L + AERA++  ++ GC+ 
Sbjct: 181 E-LSTDDFSPSPGQGAIAIVARADDSKTIEMLKKIEDPDSRLEIEAERALSDFVDSGCRF 239

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302
           P+G+YA+    E+ L     + DG Q +   + G   + + +G S  EEL   G  ++
Sbjct: 240 PVGAYAKSNGSEMTLTVTAFSVDGKQFLHVSKTGDKNNPKSLGQSAGEELREKGVNDL 297


>UniRef50_A8LIJ6 Porphobilinogen deaminase n=11 Tax=Alphaproteobacteria
           RepID=A8LIJ6_DINSH
          Length = 347

 Score =  368 bits (945), Expect = e-100,   Method: Composition-based stats.
 Identities = 144/304 (47%), Positives = 191/304 (62%), Gaps = 2/304 (0%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           D+ L+I TR S LAL QAH  + +L A+   P    E+V + T GD I D  L+++GGKG
Sbjct: 38  DSPLKIGTRGSLLALAQAHETRARLSAAFDLPEEAFEIVVIKTTGDRIQDRSLSEIGGKG 97

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LF +E+E A+L+   DIAVHSMKD+PV+ P GL L T   RED RDAFV+ +  +L  LP
Sbjct: 98  LFTREIEDAMLDGSIDIAVHSMKDMPVDTPAGLALDTYLPREDVRDAFVTLDGGTLADLP 157

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G++VG+SSLRR+ QLA RRPDL +   RGNV TR+ KL +G   A  LA+AGL RLG++
Sbjct: 158 EGAVVGSSSLRRRAQLAHRRPDLQLVEFRGNVQTRMKKLGDGVAHATFLAMAGLNRLGMD 217

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
              R+A+ PE  LPAV QG +GIE R DD R  E+LAA++   +  R+  ERA  + L+G
Sbjct: 218 EVPRSAIAPEDMLPAVAQGCIGIERRADDPRAAEMLAAIHDGPSGHRLACERAYLSALDG 277

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAR 300
            CQ PI   AEL  G I LRA +  PDGS+++        +DA +MG  +AE L      
Sbjct: 278 SCQTPIAGLAELDGGSIHLRAEILRPDGSEVLSDSETAPVEDAAKMGREVAERLRARAPD 337

Query: 301 EILA 304
              +
Sbjct: 338 GFFS 341


>UniRef50_UPI00017922DC PREDICTED: similar to porphobilinogen deaminase n=1
           Tax=Acyrthosiphon pisum RepID=UPI00017922DC
          Length = 377

 Score =  368 bits (945), Expect = e-100,   Method: Composition-based stats.
 Identities = 130/364 (35%), Positives = 186/364 (51%), Gaps = 59/364 (16%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             +R+ +R+S LAL Q  +V  +L   HP +  E+V M T GD +LD PL K+G K LF 
Sbjct: 7   KTIRVGSRKSELALIQTKFVISQLKELHPEIEFEIVSMTTMGDRVLDKPLPKIGEKSLFT 66

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS---LDALP 120
           K+LEVALL    D  VHS+KD+P     G  +  I +R+DPRDA V  +      LD+LP
Sbjct: 67  KDLEVALLSGTVDFIVHSLKDLPTVMEIGTTIGAILKRDDPRDALVLRDDCKEYQLDSLP 126

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE---------YDAIILAV 171
           + S +GTSSLRR  QL  + P+L +  +RGN+ TRL KLD+ +         Y  IILA+
Sbjct: 127 SKSFIGTSSLRRTAQLKRKFPNLQVSDVRGNLNTRLKKLDSSQSTGDNTNTNYSGIILAL 186

Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231
           AG++R+G E R+   +  ++ L AVGQGA+ +ECRL D    E+L  L+H+ET L+V AE
Sbjct: 187 AGIQRMGWEKRVSQIIDSDVMLYAVGQGALAVECRLGDDYILEMLEPLHHYETVLQVVAE 246

Query: 232 RAMNTRLEGGCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQD------- 282
           R   TRL GGC  P+G  + +      + L   V + DG++ ++        D       
Sbjct: 247 RGFLTRLGGGCSAPVGIRSTVCLTKNAMSLDGAVWSLDGAEELQYSSSAELADKKVIQSH 306

Query: 283 --------------------------------------AEQMGISLAEELLNNGAREILA 304
                                                 A ++G  LAE L++ GA +I+ 
Sbjct: 307 IDQYRGEDGEPPKKCPYKQPRQFVGVTPGKISYLDLDTALKLGTELAENLISKGALDIMN 366

Query: 305 EVYN 308
               
Sbjct: 367 AAKE 370


>UniRef50_C1CYD9 Porphobilinogen deaminase n=3 Tax=Deinococci RepID=HEM3_DEIDV
          Length = 311

 Score =  367 bits (944), Expect = e-100,   Method: Composition-based stats.
 Identities = 126/310 (40%), Positives = 176/310 (56%), Gaps = 5/310 (1%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDT--PLAKVGGKGL 61
             + + TR S LAL Q  +V  +L    P     +  + T+GD   ++   +A+ G KG 
Sbjct: 2   RTVTVGTRGSTLALAQTRWVVARLKEEWPDTDFRIQTISTKGDRNRESLEAMAQKGDKGF 61

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALP 120
           +VKE+E ALL+ R DIAVHS+KD+P E P+GL + +I +R D RD  +       L  LP
Sbjct: 62  WVKEIEDALLQKRIDIAVHSLKDLPTEQPEGLEVASIPKRVDARDVLIGKEGMKRLADLP 121

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ VGTSS+RR+  L   RPDL +  LRGN+ TRL+ L   EYDAIILA AGL R  + 
Sbjct: 122 QGARVGTSSVRRKAFLRAYRPDLQVIDLRGNIDTRLAALAGDEYDAIILAAAGLIRTEMR 181

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSR--TRELLAALNHHETALRVTAERAMNTRL 238
            RI   + P+I LPA GQGA+ +E R       T E+  A++ H T  R+TAER     L
Sbjct: 182 HRIDEFVEPDILLPAPGQGALALETRSGPENDLTIEVAYAIHDHGTDDRITAEREFLAGL 241

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
             GC  P+G++A +  G + L   VGA DGS++IR    G P +   +G  LA ++L  G
Sbjct: 242 GAGCMAPVGAHASIKGGVLTLEGWVGALDGSKVIRATSIGDPAECADIGAELAGDMLGQG 301

Query: 299 AREILAEVYN 308
           A+ ++     
Sbjct: 302 AQALIDAARE 311


>UniRef50_D1CBT4 Porphobilinogen deaminase n=1 Tax=Thermobaculum terrenum ATCC
           BAA-798 RepID=D1CBT4_THET1
          Length = 300

 Score =  367 bits (944), Expect = e-100,   Method: Composition-based stats.
 Identities = 111/295 (37%), Positives = 170/295 (57%), Gaps = 2/295 (0%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
            V+++ TR S LALWQ  +V ++L + +PG   E V +    D   D P++ +G  G+F 
Sbjct: 2   KVIKVGTRGSKLALWQTQWVINRLRSLYPGFQFEPVVIKVTSDRSPDAPISAIGQVGVFT 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           K++E ALL     +AVHS+KD+P     G  +    EREDPRD  +      +  L   S
Sbjct: 62  KDIEQALLAGDIHLAVHSLKDLPTLSTPGTVIAAFTEREDPRDCILWPKGQPMPDL-NNS 120

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            VGTSS+RR   +    P+  + +LRGNV TR+ K+  G YD +++A A +KR+ L    
Sbjct: 121 RVGTSSVRRSALVRSYWPNANVVNLRGNVDTRVRKMLEGNYDVVLMAYAAVKRMDLPVEF 180

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
           +  LP +  +P+ GQG + ++ R DD +   +L A+N   + +   AER++   L GGC 
Sbjct: 181 K-PLPLDSWVPSAGQGIIAVQAREDDQQIIGMLNAINFFPSKVAYLAERSLMRALGGGCS 239

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
           +P+G+YAEL DGE+ L  +V APDGSQ++   R   P  A+ +G  +A E+L+ G
Sbjct: 240 MPVGAYAELHDGELSLIGMVAAPDGSQVVITRRVDTPDQADHLGERVAREMLDLG 294


>UniRef50_C3WGN0 Porphobilinogen deaminase n=5 Tax=Fusobacterium RepID=C3WGN0_9FUSO
          Length = 301

 Score =  366 bits (941), Expect = e-100,   Method: Composition-based stats.
 Identities = 122/311 (39%), Positives = 172/311 (55%), Gaps = 13/311 (4%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPL--AKVGGK 59
           +   + I +R S LAL QA  VK+ L A++P L  E+  +VT GD  L +    +    K
Sbjct: 1   MKRHVVIGSRGSILALAQASLVKNSLEANYPDLTFEIKEIVTSGDKDLKSNWENSNASLK 60

Query: 60  GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119
             F KE+E  LL+ + DIAVHSMKD+P   P+GL    I +RED RD  +S N   L  L
Sbjct: 61  SFFTKEIEQELLDGQIDIAVHSMKDMPAVSPKGLICGAIPDREDARDVLISKNG-FLVTL 119

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179
           P G+ +GTSSLRR   L   RPD  I+ LRGN+ TRL KL+  +YDAIILA AGLKR G+
Sbjct: 120 PQGAKIGTSSLRRVMNLKAIRPDFEIKHLRGNIHTRLKKLETEDYDAIILAAAGLKRTGM 179

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
             +I   L  E   PA  QG + I+CR +D   + +L ++++ + A  V  ER  +   +
Sbjct: 180 ADKITEYLSGEAFPPAPAQGVLYIQCRENDEEIKGILKSIHNEDIAKIVEIEREFSKIFD 239

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
           GGC  P+G Y+++ + +I   A   + DG Q      R   +D    G  +A    +  A
Sbjct: 240 GGCHTPMGCYSQVDEDKIKFIAAY-SHDGKQ-----IRVVIEDDLTKGKEIA----HMAA 289

Query: 300 REILAEVYNGD 310
            EI A++  G+
Sbjct: 290 EEIKAKINKGN 300


>UniRef50_Q3YSA8 Porphobilinogen deaminase n=17 Tax=Rickettsiales RepID=HEM3_EHRCJ
          Length = 298

 Score =  365 bits (939), Expect = e-100,   Method: Composition-based stats.
 Identities = 112/293 (38%), Positives = 175/293 (59%), Gaps = 3/293 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR S LAL Q   V + L    P + +++V + T GD+    P+  +GGKGLF+KE
Sbjct: 3   IRIGTRGSVLALAQTLEVTNLLNRYFPEINIQVVKIKTSGDINNKVPINTIGGKGLFIKE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E ALL  + D+AVHS+KD+P  +  GL +  + +R  P D FVS+ Y S+ +LP  + V
Sbjct: 63  IEEALLIGKVDLAVHSVKDIPAFYCDGLIIPCVLKRSSPYDVFVSSKYQSIKSLPINATV 122

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS+RR+ QL   RPDL +  +RGN+ TR+ K D GE+D I+LA AGL R+   + I+ 
Sbjct: 123 GTSSIRRKVQLNYLRPDLQVIPVRGNIDTRILKSDIGEFDGIVLAEAGLIRINKCNVIKE 182

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L  +I L AVGQGA+ ++CR DD      +  LN H++ + V AER+    + G C  P
Sbjct: 183 VLDSKIMLSAVGQGAICVQCRADDYNIINKIKVLNCHKSYVCVIAERSFLKTINGSCDTP 242

Query: 246 IGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           + + A+ +D   I++  ++      +++  +      +AE+ GI + ++L+N 
Sbjct: 243 LAALAQYVDSDTIYMSCMLSNE--KEMVFSDCYFKECNAEESGIDMGKKLINE 293


>UniRef50_B0K2L4 Porphobilinogen deaminase n=7 Tax=Bacteria RepID=B0K2L4_THEPX
          Length = 299

 Score =  364 bits (936), Expect = 2e-99,   Method: Composition-based stats.
 Identities = 110/296 (37%), Positives = 172/296 (58%), Gaps = 3/296 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +  V+++ TR S LAL Q   V +++         E+V + T+GD ++D P++++GGKG+
Sbjct: 1   MKKVIKVGTRSSELALKQTAMVINEIKKFRQDFEFEIVKITTQGDALIDKPVSEIGGKGV 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FVKE+E ALL+   D+AVHSMKD+P E P+GL L+ + +REDP+D FVS +      L  
Sbjct: 61  FVKEIESALLKGEIDMAVHSMKDMPYEIPKGLKLMAVLKREDPKDVFVSGDGTQFMDLKE 120

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ +GTSSLRRQ QL   +PD+ I  +RGNV TRL K++    D I+L+ AGL RLGLE+
Sbjct: 121 GAKIGTSSLRRQVQLKALKPDIQIVPIRGNVRTRLKKMEELNLDGIVLSAAGLHRLGLEN 180

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            I    PP++ +PA  QG + +E     D+  +E    +   +T    + ER +      
Sbjct: 181 IITEYFPPDVVVPAPCQGILAVEIAESFDNIFQEFYPYIVDRKTFFEASVERELLKAFGV 240

Query: 241 GCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
            C+ P G+YA+    + E  +   V     +++++ E  G  ++ ++M   L EE 
Sbjct: 241 NCRQPFGAYAQYRKEEDEEKINIKVAYQKENKLLKSEVTGLIEETDKMIEKLIEEF 296


>UniRef50_UPI0000583C22 PREDICTED: hypothetical protein n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000583C22
          Length = 324

 Score =  363 bits (933), Expect = 4e-99,   Method: Composition-based stats.
 Identities = 125/315 (39%), Positives = 179/315 (56%), Gaps = 13/315 (4%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
            ++R+ +R+S LA+ Q ++V + L   HP    ++V M T GD I D PLA +G   LF 
Sbjct: 6   EIVRVGSRKSELAMIQTNHVVEMLQKVHPETEFKIVTMETIGDHIQDKPLASIGESNLFT 65

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALP 120
           KELE AL  +  D+ VHS+KD+P   P  + +  ICEREDP DA V +      S++ + 
Sbjct: 66  KELEKALALDEVDMLVHSLKDMPSRLPSNMAIGAICEREDPHDALVLHKKLTGISIETMK 125

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-YDAIILAVAGLKRLGL 179
            GS++GTSS+RR  QL  + P L+ + +RGN+ TRL KLD G+ YD ++LAVAG+ R+G 
Sbjct: 126 EGSVLGTSSVRRVAQLKRKFPHLVFKDVRGNLNTRLRKLDEGQVYDGLVLAVAGMMRMGW 185

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
           E RI   L P+I   +V QGA+GIE +  + R  ELL  LNH  T +R  AER +   LE
Sbjct: 186 EHRISQILKPDICKYSVSQGALGIEIKTKNRRMHELLRQLNHVPTLIRCIAERGLLKTLE 245

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGA------PQDAEQMGISLAEE 293
           GGC  P+  ++EL +    L A     +    +              Q+AE +G+S+A+ 
Sbjct: 246 GGCSAPVAVHSELEENRHSLDAE---TNEEMKLFSSVIAPWVSQHAMQEAEALGVSVAKG 302

Query: 294 LLNNGAREILAEVYN 308
           L + GA  IL     
Sbjct: 303 LFDKGAGPILEAAKE 317


>UniRef50_C3XEZ5 Porphobilinogen deaminase n=3 Tax=Campylobacterales
           RepID=C3XEZ5_9HELI
          Length = 328

 Score =  362 bits (929), Expect = 1e-98,   Method: Composition-based stats.
 Identities = 146/315 (46%), Positives = 190/315 (60%), Gaps = 12/315 (3%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62
           +  L + TR S LALWQA+++K+KL +   G  V L  + T+GD ILD PLAK+GGKGLF
Sbjct: 12  EKPLVLGTRGSLLALWQANHIKEKLESL--GFQVVLKTIKTKGDKILDAPLAKIGGKGLF 69

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122
            KELE  LL    D AVHS+KDVP+  P  L LV+I +RED RD FVS  Y  + +LP G
Sbjct: 70  TKELENELLSGGIDFAVHSLKDVPIAIPPELMLVSITQREDARDCFVSEKYADIASLPQG 129

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           + VGT+SLRR  QL   R DL  +SLRGNV TRL KL  GE+DAIILA AGL RL L+  
Sbjct: 130 AKVGTTSLRRSMQLKRIRQDLDTQSLRGNVQTRLEKLRKGEFDAIILASAGLNRLDLKDD 189

Query: 183 IRAA--LPPEISLPAVGQGAVGIECRL-------DDSRTRELLAALNHHETALRVTAERA 233
           I     L     +PA+GQG++GIECR         D    ++L +L+  ++AL    ERA
Sbjct: 190 IGFISHLQINQFIPAMGQGSLGIECRDPKYSPDFRDQAIMKVLESLHDSKSALCCNIERA 249

Query: 234 MNTRLEGGCQVPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAE 292
               L GGCQ PIG +A+++D + I ++ +VG  D S+++   R     + E     +  
Sbjct: 250 FIQLLGGGCQSPIGIHAQILDSKEIEIQCVVGNLDASKVLTETRVCNKGEVEYALQDMIN 309

Query: 293 ELLNNGAREILAEVY 307
            L  NG  EIL EV 
Sbjct: 310 TLKKNGVMEILEEVR 324


>UniRef50_Q5HBG1 Porphobilinogen deaminase n=2 Tax=Ehrlichia ruminantium
           RepID=Q5HBG1_EHRRW
          Length = 299

 Score =  360 bits (925), Expect = 3e-98,   Method: Composition-based stats.
 Identities = 112/298 (37%), Positives = 177/298 (59%), Gaps = 3/298 (1%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M    + + TR S LA+ QA  VK  L    P + V++V +VT GD+     L+++GGKG
Sbjct: 1   MNSMNVYVGTRGSILAIAQAMEVKKLLYNYFPDINVQIVHIVTSGDINDKISLSEIGGKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LF+KELE ALL    D+AVHSMKDVP  +   L +  I +R  P D F+S+ Y SL +LP
Sbjct: 61  LFLKELEEALLTGTIDLAVHSMKDVPAFYCDSLVIPCILKRSSPYDVFISSKYQSLRSLP 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
             +++GTSS+RR+ QL      + +  +RGNV TR+ KL+ G+YD IILA AGL R+   
Sbjct: 121 DNAVIGTSSIRRKVQLMRLLSSVQVVPIRGNVDTRILKLEAGQYDGIILAKAGLMRINKT 180

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
             I+  L P++ L AVGQGA+GI+CR +D +  +++  LN  ++ + V AER+    + G
Sbjct: 181 HVIKEVLDPQVMLSAVGQGAIGIQCRANDYKMIDMIKILNCKKSYISVAAERSFMKTVNG 240

Query: 241 GCQVPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
            C  P+ + A+ ++   +++  ++   +  + +  +      DAE  GI++  +L++ 
Sbjct: 241 SCDTPLAALAKYVNSDTLYMSCMLSNEE--KTVFSDCYFNECDAEISGINMGNDLMDQ 296


>UniRef50_C6XGK7 Porphobilinogen deaminase n=1 Tax=Candidatus Liberibacter asiaticus
           str. psy62 RepID=C6XGK7_LIBAP
          Length = 307

 Score =  359 bits (923), Expect = 6e-98,   Method: Composition-based stats.
 Identities = 113/297 (38%), Positives = 162/297 (54%), Gaps = 2/297 (0%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGG 58
           M     RI TR SPLAL  A   +  LM  H  P   + ++P+ T+GD I +  L ++GG
Sbjct: 1   MEKKPFRIGTRCSPLALAHAFETRSSLMDVHKIPPHNIVIIPLSTKGDRITNRTLTEIGG 60

Query: 59  KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118
           KGLF +E+E  L+    D AVHS KD+P +  +GL +     RED RD F+S+   SL  
Sbjct: 61  KGLFTEEIEKKLISGEIDCAVHSAKDMPTKLLKGLQISAYLPREDIRDVFISHTAQSLKD 120

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178
           L   S++GTSSLRR+  L   R D+ +   RG + TRL+KL+N +  AI+LA AG+KRL 
Sbjct: 121 LALHSVIGTSSLRRKALLLRWRSDISVIDFRGKIETRLNKLNNNKAHAILLAYAGIKRLK 180

Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
            E  I+  L  E   P+ GQGA+ IE  +++ + +EL+  +NH +T   V  ERA    L
Sbjct: 181 KEKVIKEILNIEDFPPSPGQGAICIETHVNNPKAQELVKVINHEDTWDSVNCERAFLAEL 240

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295
           +G C+  I  +A      ++   +V A DG       R G   DA  +G   A+ + 
Sbjct: 241 DGSCKSAIAGFAYCKGSTLYFYGIVLASDGKIFHEVSRNGNRCDAINIGRDAAQYIR 297


>UniRef50_Q2S2A6 Porphobilinogen deaminase n=1 Tax=Salinibacter ruber DSM 13855
           RepID=Q2S2A6_SALRD
          Length = 323

 Score =  359 bits (921), Expect = 1e-97,   Method: Composition-based stats.
 Identities = 144/307 (46%), Positives = 192/307 (62%), Gaps = 5/307 (1%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62
            + L + TR S LAL QA+ V+ +L A+  G  VEL  + TRGD   DTP++++G + +F
Sbjct: 4   SDPLVLGTRGSELALRQANVVRSRLEAA--GHRVELETITTRGDEATDTPISEIGDEAVF 61

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN--YDSLDALP 120
            KEL+ ALL+   D+AVHS+KD+P   P GL L  I EREDPRDAFV++      L  LP
Sbjct: 62  TKELDRALLQGGVDLAVHSLKDIPSTVPSGLALAAIGEREDPRDAFVAHPSFDGHLHDLP 121

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ V T+SLRR  QL   R DL +  +RGNV TRL KL   ++  ++LAVAGL RLGL 
Sbjct: 122 EGATVATASLRRTAQLLTWRSDLEVVPVRGNVDTRLEKLGESDWTGMVLAVAGLVRLGLS 181

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLA-ALNHHETALRVTAERAMNTRLE 239
             IR  + P + +PAVGQGA+GI CR D    R+LL   L+H  +     AERA   ++ 
Sbjct: 182 LHIRDRIDPSLIVPAVGQGALGIACREDQDALRDLLRETLHHAPSGHAANAERAFLKKVG 241

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
           GGCQVP+G++A + DG + L A + A DGS+  R ERR AP+D   +G  LA +LL  G 
Sbjct: 242 GGCQVPLGAWAHIDDGTLVLDACIAALDGSEHYRDERRCAPEDGAAVGRKLAADLLAMGG 301

Query: 300 REILAEV 306
             IL +V
Sbjct: 302 DHILDDV 308


>UniRef50_D0NJW2 Porphobilinogen deaminase n=2 Tax=Phytophthora infestans T30-4
           RepID=D0NJW2_PHYIN
          Length = 361

 Score =  358 bits (919), Expect = 2e-97,   Method: Composition-based stats.
 Identities = 124/320 (38%), Positives = 174/320 (54%), Gaps = 11/320 (3%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGK--- 59
              + +++R+S LA+ Q + V   L    P L   +    T GD +LD  L+ +G     
Sbjct: 13  KRTIFVSSRKSQLAMAQTNTVIAMLEERFPDLQFVVGQEDTVGDQVLDRHLSDLGTTTAS 72

Query: 60  GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY------ 113
           GLF K LE ALL   A  AVHS+KD+P   P GL L  I +RE P DA V +        
Sbjct: 73  GLFTKSLEEALLAKAASFAVHSLKDMPTTLPDGLVLAAITKRESPEDAAVIHPKHKEKGI 132

Query: 114 DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE-YDAIILAVA 172
            +L  LP GS++GTSSLRR+  L  + P   I+++RGN+ TRL+KLD  + YDAII+A  
Sbjct: 133 KTLQELPEGSVIGTSSLRREALLRSQFPTFEIKTVRGNIQTRLAKLDEHDDYDAIIVAAC 192

Query: 173 GLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232
           G +R  L  RI   LP +     VGQG++G+ECR DD  T E+L  +   ++A    AER
Sbjct: 193 GFRRGELGDRIDEILPMDTFGYGVGQGSIGVECRADDEETIEMLKTITDEKSAQLCKAER 252

Query: 233 AMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAE 292
           ++   LEGGCQ+ +G  A L +  + L A V + DG + +     G     E++G  LAE
Sbjct: 253 SLLYHLEGGCQIAMGVSATLDEDTLTLNATVLSRDGKESVHETISGPRTQCEELGKQLAE 312

Query: 293 ELLNNG-AREILAEVYNGDA 311
              NN  AR++L +     A
Sbjct: 313 RFWNNELARKVLGKTRQKRA 332


>UniRef50_Q4HT06 Porphobilinogen deaminase n=1 Tax=Campylobacter upsaliensis RM3195
           RepID=Q4HT06_CAMUP
          Length = 308

 Score =  357 bits (917), Expect = 3e-97,   Method: Composition-based stats.
 Identities = 151/305 (49%), Positives = 201/305 (65%), Gaps = 4/305 (1%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             L IATR+SPLALWQ+ +V D L  +H G+ V L    T+GD++LD+PLAK+GGKGLF 
Sbjct: 2   KKLIIATRKSPLALWQSEFVADILRKTH-GIEVHLEGFSTKGDILLDSPLAKIGGKGLFT 60

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KELE A+LEN+A +AVHS+KDVP   PQGL L  +  RED  DA +S  Y  L+ALP  +
Sbjct: 61  KELENAMLENKAHLAVHSLKDVPSFLPQGLVLAALSVREDDTDALLSELYKDLNALPQNA 120

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            VGT+SLRR+ QL   RPDL I +LRGNV +RL +L  GE+DAIILA AG+KRLGLES +
Sbjct: 121 KVGTTSLRRKMQLLSLRPDLHIINLRGNVNSRLKRLKGGEFDAIILASAGVKRLGLESEV 180

Query: 184 RAA--LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
           +       +  +PA  QG +GI+   D +    LL  LN  ++ +  T ER     LEGG
Sbjct: 181 KFIYRFSKDELVPAATQGILGIQS-PDKNEILTLLQCLNDEKSLIESTVERDFIRTLEGG 239

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           CQVPIG  AEL+  +I +R+++G PDGS+I+R +R    ++ +  G  LA E +  GA+E
Sbjct: 240 CQVPIGINAELMGEQITVRSILGLPDGSEILRDKRIILKKNYQGFGERLALEFIKRGAKE 299

Query: 302 ILAEV 306
           +L   
Sbjct: 300 LLKRA 304


>UniRef50_C7N5L0 Porphobilinogen deaminase n=2 Tax=Slackia RepID=C7N5L0_SLAHD
          Length = 318

 Score =  357 bits (917), Expect = 3e-97,   Method: Composition-based stats.
 Identities = 121/313 (38%), Positives = 167/313 (53%), Gaps = 5/313 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +     I TR S LALWQ   V   +M + P + VE+    T GD+ L +PLA++G KGL
Sbjct: 1   MPERFVIGTRGSKLALWQTETVGRAIMRAFPEIEVEIRVRNTTGDINLASPLAEIGDKGL 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDA 118
           F +ELE  LL    D+ VHS+KD+  E P+G  +  +  R D RD  V        SL  
Sbjct: 61  FTRELETDLLLGEVDMCVHSLKDLETEQPEGCVVAGVLPRADARDVLVCGPRIQAASLAE 120

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178
           +P GS +GT S RR  QL    P+++   +RGNV TR++K +  +Y+  ILA AG+KR+G
Sbjct: 121 VPEGSRIGTGSRRRVAQLKANFPNMVPEGIRGNVDTRVAKAEGDDYEGAILAAAGMKRMG 180

Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
            E  I A LP E  +PA GQGA+ +E    + R  ++  ALN   T     AER +   L
Sbjct: 181 YEDHIAAYLPIEDMIPAPGQGAIAMEVLKKNERAYQIARALNDPVTKACTDAERFVLFSL 240

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ--DAEQMGISLAEELLN 296
           EGGC  PIG++  L DG+    A V +  G++  R          D   M   +  EL+ 
Sbjct: 241 EGGCSAPIGAHCRLEDGKYIFDACVLSLGGTKAARCHLEADADSADPMDMAWEVVSELIG 300

Query: 297 NGAREILAEVYNG 309
            GAR IL ++ NG
Sbjct: 301 EGARAILRDIKNG 313


>UniRef50_Q11XT5 Porphobilinogen deaminase n=8 Tax=Bacteria RepID=HEM3_CYTH3
          Length = 312

 Score =  354 bits (909), Expect = 2e-96,   Method: Composition-based stats.
 Identities = 125/310 (40%), Positives = 172/310 (55%), Gaps = 4/310 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           ++  +RI TR S LALWQA +V   L     GL  ++V + T GD ILD  L+K+G KGL
Sbjct: 1   MNKTVRIGTRGSKLALWQAEHVAACLQTK--GLEPQIVIIDTTGDKILDQSLSKIGSKGL 58

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F +ELE  L     DIAVHS KD+      G+ ++ I ERE   D  VS+          
Sbjct: 59  FTEELEEQLHAGTIDIAVHSAKDLQTHLKGGMYILAITERELVNDVLVSHKPIDTLKNNP 118

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
             I+GTSS RR+  L +  P   +  +RGN+ TR+ K++ G  DA++LA AG+ R+G +S
Sbjct: 119 DLIIGTSSTRRRALLRKFYPQAKMVDMRGNLQTRIRKMEEGACDAMLLAYAGMHRMGYDS 178

Query: 182 RIRAALPPEISLPAVGQGAVGIECRL--DDSRTRELLAALNHHETALRVTAERAMNTRLE 239
            I+  L  E  +PA GQG + IE     D  +   + A LN   T   V+AERA    LE
Sbjct: 179 LIKEKLSLEEFIPAAGQGTLAIEAASTLDKEKAAVIRAVLNDAATETAVSAERAFLRTLE 238

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
           GGC +P+ + A   D +  L   + + DG++ +R E R    DAEQ G+ LA  LL +GA
Sbjct: 239 GGCSIPVFALAVERDTDYLLTGGIVSLDGTKYLRKEIRFTAADAEQRGVELATVLLKDGA 298

Query: 300 REILAEVYNG 309
            EILAE+  G
Sbjct: 299 DEILAEIKKG 308


>UniRef50_A6GB01 Porphobilinogen deaminase n=2 Tax=Bacteria RepID=A6GB01_9DELT
          Length = 322

 Score =  354 bits (909), Expect = 2e-96,   Method: Composition-based stats.
 Identities = 138/309 (44%), Positives = 182/309 (58%), Gaps = 6/309 (1%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
             LR+ TR S LALWQA+ ++D+L+A+    GL VELV +VT+GD + D PL +VGG GL
Sbjct: 9   RKLRLGTRGSALALWQANMIRDRLLAAWGAQGLEVELVRVVTKGDRVTDRPLNQVGGMGL 68

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD--SLDAL 119
           FVK LE  LL    D AVHSMKD+P   P+GL L +  ER DPRDAF++      +L  L
Sbjct: 69  FVKGLEDKLLAGEIDFAVHSMKDMPGTLPEGLTLASTPERADPRDAFLAAPGRDVTLATL 128

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179
           PAGS +GTSSLRR        P L I  +RGNV TR+ K+  GE DA++LA AGL RLG 
Sbjct: 129 PAGSRLGTSSLRRGALAKRINPGLEIVPIRGNVPTRMGKIAEGEVDAVLLAAAGLDRLGK 188

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
              I   L P+  +PA  QG + IE R  D+    L   L H  T++   AER+    L+
Sbjct: 189 GEAITERLDPDAFMPAACQGVLAIELRAADTDIAALFEPLGHGPTSIVAAAERSYLATLQ 248

Query: 240 GGCQVPIGSYAELIDG--EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           GGCQVP+  +A L +    + +  LV  PDGS +   E  G   DA Q+G  +A E+L  
Sbjct: 249 GGCQVPLACHARLSEDGRRVRVEGLVVEPDGSTVYASEAEGPVADAAQLGAGVAREVLAA 308

Query: 298 GAREILAEV 306
           G + ++  +
Sbjct: 309 GGQGVIDRL 317


>UniRef50_A6DBT5 Porphobilinogen deaminase n=1 Tax=Caminibacter mediatlanticus TB-2
           RepID=A6DBT5_9PROT
          Length = 295

 Score =  354 bits (909), Expect = 2e-96,   Method: Composition-based stats.
 Identities = 132/296 (44%), Positives = 177/296 (59%), Gaps = 8/296 (2%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            L IATR S LALWQA +VK +L     G  V+L  + T GD ILD PLA +GGKGLF+K
Sbjct: 2   KLTIATRGSKLALWQAEWVKKRLENL--GHEVDLKIVTTTGDKILDKPLASIGGKGLFIK 59

Query: 65  ELEVALLENRADIAVHSMKDVPVEF-PQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           E+E ALL   A IAVHS+KD P E+  +   L  + +RE   D F+S  +++L  LP  +
Sbjct: 60  EVEEALLRGEAQIAVHSLKDFPTEYNKEHFTLAAVPKREAVEDVFLSETFETLAELPHNA 119

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL--ES 181
           +VGTSS+RR  QL   R DL+I  LRGNV TR++KL  GEYDAIILA AG+KRL L  E 
Sbjct: 120 VVGTSSIRRAMQLKAFREDLVISDLRGNVDTRINKLKKGEYDAIILAYAGVKRLNLIKEV 179

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
           +    L  +I +PA+GQGA+GIE  + D +  E +  LN   T + VT ER     L  G
Sbjct: 180 KYFEILDTDIMIPAMGQGALGIET-IKDEKVIEAVKPLNDLWTKIEVTIERDFIDELNLG 238

Query: 242 CQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
           C  P+G  A++ +D  I ++A +   + +++I+ E      + E  G   AEE   
Sbjct: 239 CHAPVGVNAKIMVDDSIKIKAAILDKN-NKVIKKEMVVPFDEWENAGREFAEEFKE 293


>UniRef50_A8U3E9 Porphobilinogen deaminase n=1 Tax=alpha proteobacterium BAL199
           RepID=A8U3E9_9PROT
          Length = 321

 Score =  353 bits (906), Expect = 6e-96,   Method: Composition-based stats.
 Identities = 131/306 (42%), Positives = 178/306 (58%), Gaps = 7/306 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLV--VELVPMVTRGDVILDTPLAKVGGKGLFV 63
           L + +R SPLAL Q H V+D+L A+ P L   + +  + T GD + D PLA++GGKGLF+
Sbjct: 15  LTLGSRGSPLALRQTHEVRDRLAAAWPELAGAIAVQEIRTTGDAVRDRPLAEIGGKGLFI 74

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KE+E AL+  + D AVHSMKD+         LV +  REDPRDA++S   D +D LP+G+
Sbjct: 75  KEIEQALMAGQIDAAVHSMKDMETTIAPASVLVAVLPREDPRDAWLSPIADRVDDLPSGA 134

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            +GT+S+RR  Q+  RRPDL +   RGNV TRL KL  GE     LA AGL RLG+  + 
Sbjct: 135 KIGTASVRRAAQVLNRRPDLQVVLFRGNVDTRLRKLAEGEVAGTFLAAAGLSRLGMLDKA 194

Query: 184 RAALPPEISLPAVGQGAVGIECRLD-----DSRTRELLAALNHHETALRVTAERAMNTRL 238
              L  +  LPAV QGA+G++CR       D+  R  L+ L+   + LRVTAERAM   L
Sbjct: 195 TRILEVDEMLPAVSQGAIGVQCRDGEASARDAEIRNWLSILDDRPSRLRVTAERAMLATL 254

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
           +G C+ PI  +A L    + L  +V + DG          A  D E +G ++ E +L  G
Sbjct: 255 DGSCRTPIAGHATLGGARLTLSGMVFSLDGQSSHGAVDTSATDDPEALGRTVGEAILARG 314

Query: 299 AREILA 304
            R  LA
Sbjct: 315 GRNFLA 320


>UniRef50_B3U3W9 Hydroxymethylbilane synthetase n=1 Tax=Oxyrrhis marina
           RepID=B3U3W9_OXYMA
          Length = 395

 Score =  352 bits (904), Expect = 9e-96,   Method: Composition-based stats.
 Identities = 129/303 (42%), Positives = 168/303 (55%), Gaps = 3/303 (0%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMA-SHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           LRI TR SPLAL QA  V+ +       G  +++  + T GD ILD  LA VGGKGLF K
Sbjct: 76  LRIGTRGSPLALAQARDVESRAREQLQQGGEIDICVISTEGDRILDRALADVGGKGLFTK 135

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           EL+ ALL    D  VHSMKDVP     G  +V    RED RD F+S  Y +L  LP G++
Sbjct: 136 ELDRALLSGEVDCCVHSMKDVPTTVAPGTEIVAYLPREDTRDVFLSAKYATLADLPDGAV 195

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGT+SLRRQ Q+  +  ++++ + RGNV TRL KL  G  D   LA AGLKRLG+ +   
Sbjct: 196 VGTASLRRQAQILAQ-KNVVVTNFRGNVQTRLRKLAAGTVDCTFLAYAGLKRLGMLAEAT 254

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L     LPA+ QGAVGI+ R +D+  R  L+ L+H  T L V  ERA    L+G C+ 
Sbjct: 255 QVLEWSDMLPAIAQGAVGIQIRSNDAALRGTLSQLDHEPTRLAVETERAFLRALDGSCRT 314

Query: 245 PIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           PI   A +  D  +  R  V + DG Q         P D  ++G +L ++L      E  
Sbjct: 315 PIAGQAWIGPDSRLAFRGQVLSADGKQRFERVGDCLPCDGPELGKTLGDDLRREAGEEFF 374

Query: 304 AEV 306
           AE+
Sbjct: 375 AEL 377


>UniRef50_A6GVP0 Hydroxymethylbilane synthase n=18 Tax=Bacteroidetes
           RepID=A6GVP0_FLAPJ
          Length = 308

 Score =  352 bits (903), Expect = 1e-95,   Method: Composition-based stats.
 Identities = 111/311 (35%), Positives = 173/311 (55%), Gaps = 8/311 (2%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M    ++I TR S LALWQAH+V+  L     G   +++ + ++GD+ILD PL ++G  G
Sbjct: 1   MAKKTIKIGTRDSELALWQAHHVEKMLNDL--GHKTKIIAVKSQGDIILDKPLYELGITG 58

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           +F K L++A++    DIAVHSMKDVP   PQG+    + ER + +D  V NN  +LD L 
Sbjct: 59  IFTKTLDIAMVNGDIDIAVHSMKDVPTALPQGIVQAAVLERANEKDILVYNN--NLDFLN 116

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
             + + T SLRRQ Q   + P+  +  LRGNV TR+ KL +  ++  + A AGL+R+ ++
Sbjct: 117 TQATIATGSLRRQAQWLHKYPNHKVVDLRGNVNTRMQKLQDNNWNGAVFAAAGLERINIK 176

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
                 +  +  +PA  QGA+ +    +D+   + LA LNH ET +    ER     LEG
Sbjct: 177 PE--NYINLDWMIPAPAQGAMMVVAMGNDTYCLDALAELNHIETEITTYIERQFLRTLEG 234

Query: 241 GCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
           GC  PIG+YA     D  I  + ++ + DGSQ I  ++    Q+ +Q+G    +E+  NG
Sbjct: 235 GCTAPIGAYARFNEKDETIHFQGVLFSLDGSQKIEIKKIVEIQEWKQLGYHAGQEIFENG 294

Query: 299 AREILAEVYNG 309
             +++  +   
Sbjct: 295 GVQLMKTIKEK 305


>UniRef50_C4Z552 Porphobilinogen deaminase n=8 Tax=Bacteria RepID=HEM3_EUBE2
          Length = 295

 Score =  350 bits (900), Expect = 2e-95,   Method: Composition-based stats.
 Identities = 123/291 (42%), Positives = 166/291 (57%), Gaps = 5/291 (1%)

Query: 7   RIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66
           RI TR S LAL Q+ YVK ++  ++P    ELV + T GD + D PLA +G KG FVKE+
Sbjct: 4   RIGTRGSKLALVQSEYVKRRMEEAYPEDTFELVIIKTTGDKVTDKPLAAIGTKGFFVKEI 63

Query: 67  EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126
           E ALL    D+AVHSMKD+P E   GL      +RED RD  +     S   LP+G+++G
Sbjct: 64  EEALLSGSIDMAVHSMKDMPAECAAGLTFAKAWKREDCRDVLILKTAGSFSELPSGAVIG 123

Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY--DAIILAVAGLKRLGLESRIR 184
           T SLRR CQLA  RPD+   ++RGNV TR++KL +  Y  D I+LA AGL RLG  S I 
Sbjct: 124 TGSLRRACQLAMLRPDIQFTAIRGNVDTRINKLMDDSYGLDGIVLAAAGLNRLGRSSEIT 183

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L PE+ +PA  QG + IE    ++   + + AL+   +     AER       GGC  
Sbjct: 184 EYLDPEVVIPAPAQGVLAIETAEVNTELLDKINALSDDNSDREAVAERTFLRLTGGGCHA 243

Query: 245 PIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
           P+G++    D G++ +  L G  D S+I+R E  G   D+E +G   A  L
Sbjct: 244 PVGAHCVTKDNGDLRMVVLFGNDDCSRILRIEVTGT--DSEAVGHEAARML 292


>UniRef50_B2W5W6 Porphobilinogen deaminase n=2 Tax=Pleosporineae RepID=B2W5W6_PYRTR
          Length = 399

 Score =  350 bits (900), Expect = 2e-95,   Method: Composition-based stats.
 Identities = 128/348 (36%), Positives = 177/348 (50%), Gaps = 45/348 (12%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG----KG 60
            + I TR S LA  QA  V+  L  ++P     + P++ +GD    TPL ++      K 
Sbjct: 30  PVNIGTRNSVLAQIQARAVERSLKDAYPERTYNICPVIVQGDRDKITPLQQLSQGENAKS 89

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS----NNYDSL 116
           L+  ELE  L     DI VH +KD+P + P  L L  I EREDPRDA +         +L
Sbjct: 90  LWTGELESMLESGDLDIIVHCLKDMPTQLPDHLELGAILEREDPRDALLVSPRLPKETTL 149

Query: 117 DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAGL 174
             LP G+ +GTSS+RR   L +  P L    LRGNVGTRL+KLD  +  Y AIILA AGL
Sbjct: 150 ATLPQGATIGTSSVRRAATLRKLYPHLKFADLRGNVGTRLAKLDAEDSPYSAIILAAAGL 209

Query: 175 KRLGLESRIRAALPPEI--SLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAER 232
           KR+GL++RI   L       L AVGQGA+GIE R +D   +EL++ +    T    +AER
Sbjct: 210 KRMGLDNRITQYLSSTSGGMLHAVGQGALGIEIRKNDEAMKELMSKIRCERTTRACSAER 269

Query: 233 AMNTRLEGGCQVPIGSYAELIDGE------------------------------IWLRAL 262
           A+   LEGGC VPIG       G+                              + +RA+
Sbjct: 270 ALLRTLEGGCSVPIGVETSWKGGKGLSVGPQPAKDYDKHGNAVEEDEPDVDDQELVMRAM 329

Query: 263 VGAPDGSQIIRGERR---GAPQDAEQMGISLAEELLNNGAREILAEVY 307
           V + DG + +  E        ++AE+MG  +A+ L+  GA +IL ++ 
Sbjct: 330 VVSVDGKESVEYEATRKVRNAEEAEEMGREVAKILIEKGADKILEKIN 377


>UniRef50_UPI00006CBE06 porphobilinogen deaminase family protein n=1 Tax=Tetrahymena
           thermophila RepID=UPI00006CBE06
          Length = 362

 Score =  350 bits (899), Expect = 4e-95,   Method: Composition-based stats.
 Identities = 123/339 (36%), Positives = 178/339 (52%), Gaps = 32/339 (9%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKL----MASHPGLVVELVPM--------------- 41
           + +   +IA+R S LAL Q + V D L             E+VP+               
Sbjct: 16  LKNRKFKIASRSSQLALSQTYEVIDLLVGVKELGLTKENFEVVPISNAPGKNCTLKFKIN 75

Query: 42  ------VTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGL 95
                   +GD  L  PL  +GG G+F K +EV LL    DIAVHS+KD+P    + L +
Sbjct: 76  ITNKQFTNKGDQNLKDPLYVMGGVGVFTKIVEVELLNKNGDIAVHSLKDLPTIIDERLFI 135

Query: 96  VTICEREDPRDAFVS---NNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNV 152
             +   +   D  +    +    L  LP GS++GTSSLRR   L  R P L   ++RGN+
Sbjct: 136 GAVPPLKPRGDVVIFNEKHKGKELKDLPEGSVIGTSSLRRITNLKNRYPHLKYENIRGNL 195

Query: 153 GTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRT 212
            TRL+KL+NG+YDAIILA AG+ RLG   ++   L  E  L A GQGA+G++CR DD   
Sbjct: 196 NTRLTKLENGQYDAIILAEAGVFRLGWIEKVGQFLKQEDFLYAPGQGALGVQCRADDKEA 255

Query: 213 RELLAALNHHETALRVTAERAMNTRLEG---GCQVPIGSYAELIDGEIWLRALVGAPDGS 269
             LL+ +N  E  +RV AER    +LEG   GC++PI  ++E+ID  + L   V + +  
Sbjct: 256 IALLSYINQKEPRIRVDAERQFLNKLEGVILGCKLPIAVHSEIIDQTLRLTGQVWSLEAD 315

Query: 270 QIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYN 308
           + IR    G   D + +G+ L+E++   GA EIL ++ +
Sbjct: 316 KTIREVIEGHISD-QDLGLKLSEKMKQAGAGEILEKIRS 353


>UniRef50_C6WZF5 Porphobilinogen deaminase n=1 Tax=Flavobacteriaceae bacterium
           3519-10 RepID=C6WZF5_FLAB3
          Length = 311

 Score =  350 bits (898), Expect = 4e-95,   Method: Composition-based stats.
 Identities = 107/307 (34%), Positives = 172/307 (56%), Gaps = 7/307 (2%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             ++I TR SPLALWQA  V   L  +      ++ P++++GD  L  PL  +G  G+F 
Sbjct: 10  RSIKIGTRNSPLALWQAREVARHLQNN--NHTTDITPIISKGDKNLSQPLYTLGITGIFT 67

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           K+L++ALL N  DIAVHS+KD+P + P+ + ++ + +R+ P+D  V     +   L    
Sbjct: 68  KDLDIALLNNEVDIAVHSLKDIPTQLPENVEIIAVLQRDYPQDVLVRKKDAATLELHQ-L 126

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            + TSSLRR+    +  P      +RGNV TRL+KL+  ++DA + ++A ++R+GL    
Sbjct: 127 KIATSSLRRRAFWLKEFPGTEFSDIRGNVQTRLTKLEENDFDATMFSLAAIERMGLSVD- 185

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
                  + +PA  QG V +  R +D   +EL   +NH ET + +  ER+  + LEGGC 
Sbjct: 186 --YEHLPLMIPAPAQGVVAVCARSNDPEIKELFKEINHRETRICIDIERSFLSTLEGGCT 243

Query: 244 VPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302
            PIG++AE+ D GE+     + + DG   I  +   A  + +  G  LAE++L NG RE+
Sbjct: 244 APIGAFAEINDLGEVRFTGRICSLDGQNCIETDEIFAWNEHDDFGKILAEKILQNGGREL 303

Query: 303 LAEVYNG 309
           + E+ + 
Sbjct: 304 MQEIKSK 310


>UniRef50_A9FDP9 Porphobilinogen deaminase n=1 Tax=Sorangium cellulosum 'So ce 56'
           RepID=HEM3_SORC5
          Length = 300

 Score =  349 bits (897), Expect = 6e-95,   Method: Composition-based stats.
 Identities = 152/299 (50%), Positives = 196/299 (65%), Gaps = 4/299 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   L +ATR+S LAL Q+      L A+ P L +  + +VT GD   D  L  +GGKGL
Sbjct: 1   MPTELTLATRRSALALAQSRAFARSLEAAVPDLSLRELEVVTSGDKTQDRSLQDIGGKGL 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F+KELE ALL+ RAD AVHS+KDVP E    L L  I  REDPRDA V+ +   L  LPA
Sbjct: 61  FIKELEEALLDRRADFAVHSIKDVPAEIAPALCLACIPAREDPRDALVTRSGALLAELPA 120

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ VGTSSLRR   L E RPDL+I  +RGNV TRL K+ +G +DA++LA+AGLKRLGLE+
Sbjct: 121 GARVGTSSLRRAVALREARPDLVIEPVRGNVDTRLRKVFDGVFDAVVLALAGLKRLGLEA 180

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
           R    L PE+SLPA+GQGA+GIECR  D   R++L  L   ET + V+AERA+   +EG 
Sbjct: 181 RATEVLSPEVSLPAIGQGALGIECRTADDSVRDVLGTLADAETTICVSAERAVMAAVEGS 240

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR----GAPQDAEQMGISLAEELLN 296
           C+ P+ +YA    G +WLRAL+  PDGS++ R ERR    G  ++AE++G  L  EL  
Sbjct: 241 CRTPVAAYAVRDGGALWLRALLAEPDGSRLRRAERRLSWPGNTREAERLGADLGAELKK 299


>UniRef50_A3CL78 Porphobilinogen deaminase n=1 Tax=Streptococcus sanguinis SK36
           RepID=HEM3_STRSV
          Length = 306

 Score =  347 bits (892), Expect = 2e-94,   Method: Composition-based stats.
 Identities = 126/300 (42%), Positives = 179/300 (59%), Gaps = 7/300 (2%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
            V+++ TR+S LA+ Q   + D+L A HP     LVP  T+GD +    L ++GGKG+FV
Sbjct: 2   KVIKVGTRKSKLAMTQTQQLVDQLKALHPERDFVLVPYTTKGDRLTHVSLQEIGGKGVFV 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALPAG 122
           KE+E ALL    ++AVHS+KD+P +  +G  L  I +RED RD  +      +L  LP G
Sbjct: 62  KEIERALLAGEINMAVHSLKDMPAKLAEGCALGAISQREDVRDCLIFRQAGQTLADLPKG 121

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           S++GTSS+RRQ QL  +RPDL  + LRGN+ TR+ KL+ GEYDAI+LA+AGLKRLG   +
Sbjct: 122 SLIGTSSIRRQVQLQAQRPDLAFKPLRGNIDTRIKKLEEGEYDAIVLAMAGLKRLGWLDQ 181

Query: 183 IR---AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
            R     L   + LPA+ QGA+ +ECR +D     LLAA+   +TA  V  ERA+  ++ 
Sbjct: 182 SRLHIQPLETSLCLPAISQGALAVECREEDEELLSLLAAVQDEKTAAEVAVERAVLAQMN 241

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
             C  PI ++A+       L A++   DG Q I    +G  QD +Q+      +L + GA
Sbjct: 242 ADCTFPIAAFAQKNGQGYQLEAMLAKEDG-QCIFVSLQG--QDGQQLAEQAVRQLADKGA 298


>UniRef50_Q1V167 Hydroxymethylbilane synthase n=3 Tax=Candidatus Pelagibacter
           RepID=Q1V167_PELUB
          Length = 307

 Score =  347 bits (891), Expect = 3e-94,   Method: Composition-based stats.
 Identities = 111/300 (37%), Positives = 168/300 (56%), Gaps = 3/300 (1%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVE---LVPMVTRGDVILDTPLAKVG 57
           M +  + I +R S LAL  A   ++K++       +E   +  +VT+GD + D  L++VG
Sbjct: 1   MKNRKIIIGSRGSKLALIYAEKAREKILKHSKDFGIEEVIIKEIVTKGDQVQDKRLSEVG 60

Query: 58  GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD 117
           GKGLF K +EV LLE + DIAVH++KD+P E  +GL      ER DPR+  +S +   L 
Sbjct: 61  GKGLFSKTIEVELLEKKIDIAVHALKDMPSEETRGLLTDCFLERNDPREILISKDNKHLK 120

Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177
            L + SI+GTSS RR+ Q+ + R DL  + +RGNV TR+ KL    YDAIIL+ AG+  L
Sbjct: 121 DLASNSIIGTSSYRREFQIKKIRDDLNCKLIRGNVDTRIRKLKENLYDAIILSYAGIDSL 180

Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237
           GL   I         +P  GQG + ++CR +D    ELL  ++H  T   + AER +   
Sbjct: 181 GLNQNISQTFSTSEIIPCAGQGVIALQCRDNDESLIELLKQVDHQSTHSSIKAERNVLKV 240

Query: 238 LEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           LEG C+  +G++A +   +I L   + + DGS+    +   +   AE++GI + + L   
Sbjct: 241 LEGDCETAVGAFANIEGNKINLEVELFSLDGSKRFYLKSSESVDKAEELGIEMGKTLKKM 300


>UniRef50_A0LRF1 Porphobilinogen deaminase n=1 Tax=Acidothermus cellulolyticus 11B
           RepID=HEM3_ACIC1
          Length = 331

 Score =  347 bits (890), Expect = 4e-94,   Method: Composition-based stats.
 Identities = 128/313 (40%), Positives = 165/313 (52%), Gaps = 6/313 (1%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           +VLR+ TR+S LA  Q   +   L A+  G  VE+V + + GD   D PL +  G G+FV
Sbjct: 8   SVLRLGTRRSTLARAQTEEIAGALRAA--GCRVEIVGIQSTGDRHADVPLHEFAGSGVFV 65

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
            EL  ALL    D+ VHSMKD+P      L +  I  R DPRDA V+     L  LP G+
Sbjct: 66  AELRAALLRGEVDVVVHSMKDLPTAEIPELAIAAIPRRADPRDALVTGAGCRLAELPTGA 125

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           IVGT S RR  QL   RPDL IR +RGN+ TRL KL  G Y A+I+A AGL RL      
Sbjct: 126 IVGTGSPRRAAQLRLLRPDLEIRPIRGNLDTRLGKLHAGGYAALIVAAAGLARLHRSEEA 185

Query: 184 RAALPPEISLPAVGQGAVGIECRLDD----SRTRELLAALNHHETALRVTAERAMNTRLE 239
                P + LPA GQGA+ +ECR  D     R   +LA L+   T   VTAERA+   + 
Sbjct: 186 AEFFDPTVMLPAPGQGALAVECRRADIADGGRLAGILAGLDDPATRAAVTAERALLAAVG 245

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
            GC  P+G+   +    + L A+V  P G+   R    G P DA  +G  LA +L+  GA
Sbjct: 246 AGCSAPVGALGVVTADTLQLDAVVVDPSGTTAFRRSLTGTPDDASDLGRRLAADLIRAGA 305

Query: 300 REILAEVYNGDAP 312
            ++L        P
Sbjct: 306 DQLLQAPKQTGEP 318


>UniRef50_A2Q9P7 Catalytic activity: 4 porphobilinogen+H(2)O<=>hydroxymethylbilane+4
           NH(3) n=1 Tax=Aspergillus niger CBS 513.88
           RepID=A2Q9P7_ASPNC
          Length = 346

 Score =  345 bits (887), Expect = 9e-94,   Method: Composition-based stats.
 Identities = 120/324 (37%), Positives = 173/324 (53%), Gaps = 22/324 (6%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG-----KG 60
           LR+ TR S LAL QA +V  +L ++HPG+      +V RGD    +P  K  G     K 
Sbjct: 12  LRLGTRNSKLALVQAEHVSKELTSAHPGVQFPWQTVVVRGDADKSSPFLKFAGPSDAAKN 71

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-----DS 115
           ++ +E+E  L     D+ VH +KD+P   P+   L  I  REDP DA V           
Sbjct: 72  IWTEEMETKLCAGELDLLVHCLKDMPTRLPETCTLGAIVYREDPTDALVIKEGLRSQYTD 131

Query: 116 LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAG 173
           L  LP GS+VGTSS RR+  L  R P L +   RGN+GTRL KLD+ E  + AIILA AG
Sbjct: 132 LSQLPPGSVVGTSSTRRKALLRYRYPHLKVEECRGNLGTRLKKLDDPEGPFSAIILATAG 191

Query: 174 LKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERA 233
           + R+ LE RI   LPP     AVGQGA+GIE R +D++T+ ++  +    T     AER+
Sbjct: 192 MVRINLEDRITKRLPPSEFPYAVGQGALGIEIRKEDAQTKTMVRKIEDLVTRRICLAERS 251

Query: 234 MNTRLEGGCQVPIGSYAELID-------GEIWLRALVGAPDGSQIIRGERR---GAPQDA 283
           +   L+GGC  P+  +  +          ++ L   +  P G+ ++        G  +DA
Sbjct: 252 LLRTLQGGCSSPVAVHCTVEQAPTASSPAQLRLDGTIIHPHGTTLLSERTTAEVGTDEDA 311

Query: 284 EQMGISLAEELLNNGAREILAEVY 307
           E +G ++A++LL NG + +L E+ 
Sbjct: 312 EALGATVAQQLLKNGGQALLEEIR 335


>UniRef50_C0YV01 Hydroxymethylbilane synthase n=1 Tax=Chryseobacterium gleum ATCC
           35910 RepID=C0YV01_9FLAO
          Length = 302

 Score =  344 bits (884), Expect = 2e-93,   Method: Composition-based stats.
 Identities = 110/305 (36%), Positives = 167/305 (54%), Gaps = 6/305 (1%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             +RI TR S LALWQA  V   L  +    + E+VP+V+ GD  L+ PL  +G  G+F 
Sbjct: 2   KSIRIGTRNSALALWQAREVARHLQNN--NYLTEIVPIVSSGDKNLNQPLYSLGITGVFT 59

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           ++L++ALL +  DIAVHS+KDVP + PQ + ++   ER+ P+D  +              
Sbjct: 60  RDLDIALLNDEIDIAVHSLKDVPTQLPQNIEMIAYLERDYPQDILIRKESSRNKEFHE-L 118

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            + TSSLRR+       P      +RGN+ TRL KL+ G++DA IL++AG+KR+ +E   
Sbjct: 119 KLATSSLRRRAFWLRNYPTAEFSDIRGNIQTRLQKLEEGDFDATILSLAGIKRMKMEIDY 178

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              LP    + A  QG + +    D     E++  +NH ET + V  ER   + LEGGC 
Sbjct: 179 -EMLPL--MISAPSQGVISVAGHTDKPEINEIVRQINHQETQICVEIERNFLSTLEGGCT 235

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
            PIG++AE+I  +I  +A + + DG   I  +       AE  G   A+ +L NG +E++
Sbjct: 236 APIGAFAEIIGDQIRFKAALCSLDGKNCIAVDENFVYTPAENFGEKYAKVVLENGGKELM 295

Query: 304 AEVYN 308
           AE+ +
Sbjct: 296 AEIKS 300


>UniRef50_Q0TQG4 Porphobilinogen deaminase n=32 Tax=Clostridium RepID=HEM3_CLOP1
          Length = 291

 Score =  344 bits (883), Expect = 2e-93,   Method: Composition-based stats.
 Identities = 128/292 (43%), Positives = 170/292 (58%), Gaps = 4/292 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L IATR+S LA  Q   V + L      +  + + ++T GD  LD  L K+GGKGLFVKE
Sbjct: 3   LIIATRKSKLAQVQTEKVMELLKEKE-NVDSKKLLVMTEGDRRLDVSLNKIGGKGLFVKE 61

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +E+ALL   A  AVHSMKDVP E P    LV + ERED RDAFVS N  +L  L  G+ +
Sbjct: 62  IELALLNKEAHGAVHSMKDVPFELPSEFELVAMPEREDIRDAFVSLNGSTLSNLRKGARI 121

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS+RR  QL   R DL I  +RGNV TR+ K+     D IILA AGLKRLG+E  I  
Sbjct: 122 GTSSIRRAEQLKLFRDDLEIVPIRGNVQTRIKKITEENLDGIILAAAGLKRLGMEDVISD 181

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
              P++ LPA+GQGA+GIEC        +   AL+  E    V AER+    L GGC   
Sbjct: 182 YFDPKVFLPAIGQGALGIECLKGG-EFNDYFKALDSKEVRTTVEAERSFMKVLNGGCHSL 240

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           IG+Y+E+ D ++++       +  +I++ +  G  +D   +G  LAE++L  
Sbjct: 241 IGAYSEVKDNDLYMIGTFTVNN--RIVKKDILGNKEDNILLGKKLAEKILGE 290


>UniRef50_C3PNS9 Porphobilinogen deaminase n=15 Tax=Rickettsia RepID=HEM3_RICAE
          Length = 351

 Score =  343 bits (882), Expect = 4e-93,   Method: Composition-based stats.
 Identities = 105/254 (41%), Positives = 155/254 (61%), Gaps = 1/254 (0%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           + N +RI TR+SPLAL   + V  ++    P +  E+VP++T GD+I + PL  +GGK L
Sbjct: 1   MTNSIRIGTRKSPLALIHTNLVIQQIKQFFPDINCEIVPIITSGDLIQNKPLYDIGGKAL 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F+KE+E ALL+ + D+AVHS+KDVP   P+ L +  + EREDPRD FV   Y S++ LP 
Sbjct: 61  FLKEIEQALLDKKIDLAVHSLKDVPGRIPEPLVIAAVLEREDPRDVFVCLKYKSIEELPQ 120

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG-LE 180
            +++G+S++RR+  + + RPDL +   RGNV +R+ KL  GE DA ILA  GLKRL    
Sbjct: 121 NAVIGSSAVRRKAFIQKIRPDLKVTVFRGNVDSRIKKLMTGEVDATILAYTGLKRLEVFN 180

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
                 +     LP +GQG + +E R DD+   E+   +NH  T   +  ERA    L+ 
Sbjct: 181 PEYCHLIEYSQMLPCIGQGVIAVEIRKDDNAMLEICNQINHLPTFELIKPERAFLEYLDA 240

Query: 241 GCQVPIGSYAELID 254
            C+ PI +Y++ +D
Sbjct: 241 NCRTPIAAYSQYLD 254


>UniRef50_C1AA38 Porphobilinogen deaminase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1AA38_GEMAT
          Length = 309

 Score =  343 bits (881), Expect = 5e-93,   Method: Composition-based stats.
 Identities = 151/311 (48%), Positives = 186/311 (59%), Gaps = 6/311 (1%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M+   +RI TR S LAL QA  V  +L A   G+  ELV   T GD ILD PL+ +G KG
Sbjct: 1   MMTVPVRIGTRSSELALRQARQVAAQLDAR--GVPSELVEYTTLGDRILDRPLSAIGEKG 58

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLD 117
           LF  ELE  LL  R D AVHS+KD+P   PQG+ +V + EREDPRDA V        SLD
Sbjct: 59  LFTAELEADLLAGRIDCAVHSLKDLPTADPQGIIVVALLEREDPRDALVVRAGVDAHSLD 118

Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177
            LP G+ VGTSSLRR+ QL   R DL +  LRGNVGTRL KLD G+ DA +LA AGL RL
Sbjct: 119 TLPEGARVGTSSLRRRAQLQALRSDLEVCELRGNVGTRLRKLDEGQVDAALLAAAGLHRL 178

Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237
           GL  RI A L     L A GQGA+ ++ R DD      L++L+H  T + VTAERA+   
Sbjct: 179 GLADRIVAYLDAPEWLSAPGQGAIAVQGRADDEALLSTLSSLDHAPTRVAVTAERALLAA 238

Query: 238 LEGGCQVPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
           LEGGCQVPIG+   E  +    L A++ + DGS  +RG       +    GI LA +L  
Sbjct: 239 LEGGCQVPIGAAVLEEPEYGTILHAVIVSLDGSSAVRGGYPVDHANPAASGIELARQLRA 298

Query: 297 NGAREILAEVY 307
            G  +IL+E+ 
Sbjct: 299 AGGAQILSEIR 309


>UniRef50_A8MDU3 Probable porphobilinogen deaminase n=2 Tax=Thermoproteaceae
           RepID=HEM3_CALMQ
          Length = 305

 Score =  343 bits (880), Expect = 5e-93,   Method: Composition-based stats.
 Identities = 124/304 (40%), Positives = 180/304 (59%), Gaps = 2/304 (0%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           ++RIATR S L+L Q   V D+++  +  +  +L+ + T GDV L  PL ++G KG+F +
Sbjct: 2   IIRIATRGSALSLKQTKIVMDRILEFNKDVEFKLIIVKTTGDVDLSKPLYEIGVKGIFER 61

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           E+  A+L   AD+AVHS+KD+P +    L LV    R++PRDA VS    ++D LP  SI
Sbjct: 62  EVNQAVLRGEADVAVHSLKDMPAQISNDLTLVMTPPRDNPRDALVSLRQYTVDTLPLNSI 121

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGTSSLRR+  L   R D+ ++ +RGNV TR+ KL+NGEYDA+I+A AGL+RL + + + 
Sbjct: 122 VGTSSLRRRGFLLSLRRDVTVKPIRGNVDTRIRKLNNGEYDALIMAAAGLERLSINANVS 181

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             + PE+  PA GQG +G+  R D     ++L   +  ET     AERA  +R+  GC V
Sbjct: 182 E-ISPELMPPAPGQGIIGVVARRDRDDLIKVLRRSSDEETFKEAAAERAFLSRIGAGCHV 240

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304
           P+G  A L DG       V  PDG +      R   ++ E+ G   AE+LL N AR ++A
Sbjct: 241 PLGGLALLDDGYFDFTYGVVDPDGVEKFINSTRIDARNPEEAGRVAAEDLLRN-ARGLVA 299

Query: 305 EVYN 308
            +  
Sbjct: 300 RLLK 303


>UniRef50_C1ZK04 Porphobilinogen deaminase n=1 Tax=Planctomyces limnophilus DSM 3776
           RepID=C1ZK04_PLALI
          Length = 318

 Score =  342 bits (879), Expect = 8e-93,   Method: Composition-based stats.
 Identities = 139/315 (44%), Positives = 181/315 (57%), Gaps = 16/315 (5%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           VLRIATR S LALWQA++V D L +  P L VELV + T GD +   PL + GG+G+F +
Sbjct: 3   VLRIATRASQLALWQANFVADSLRSLDPELTVELVHVTTTGDRVQGEPLRQFGGQGVFTR 62

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS----LDALP 120
           E++ ALLE RADIAVHS+KD+P     GL L  +  R    DA +     S    L  LP
Sbjct: 63  EVQAALLEGRADIAVHSLKDLPTVPTAGLELAAVPARAPVADALLLPTGHSGPASLAMLP 122

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ +GT S RRQ QL   RPDL+   +RGN+ TR+ KLD GEY+ +ILAVAGL RLG  
Sbjct: 123 RGARIGTGSPRRQAQLLRIRPDLVCSEVRGNLDTRIRKLDAGEYEGLILAVAGLSRLGWS 182

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            RI   L P    PA GQGA+G+ECR  D  T   ++ L   +T L V AERA+   LE 
Sbjct: 183 DRISLILAPPTMFPAAGQGALGLECRHGDEATIRWVSQLEDRQTRLAVDAERAVLRTLEA 242

Query: 241 GCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRG--ERRGAPQD---------AEQMGI 288
           GC  P+G++A       + L A++ APDGS+ +      +G             A ++G 
Sbjct: 243 GCHAPVGTWASWKSPETLHLEAILIAPDGSETLAAASSMQGPLSQYGSGNALDAAHELGA 302

Query: 289 SLAEELLNNGAREIL 303
           ++A  LL  GA   L
Sbjct: 303 NVAHLLLKQGASRYL 317


>UniRef50_A3ZKX4 Porphobilinogen deaminase n=1 Tax=Blastopirellula marina DSM 3645
           RepID=A3ZKX4_9PLAN
          Length = 308

 Score =  342 bits (878), Expect = 1e-92,   Method: Composition-based stats.
 Identities = 133/308 (43%), Positives = 185/308 (60%), Gaps = 5/308 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR S LA WQA++V D+L A   G  VE++ + T+GDV    PL  +GG+G+F  E
Sbjct: 4   IRIGTRGSQLAQWQANWVADQLRAV--GTDVEIIHIATQGDVTQG-PLDLIGGRGVFTTE 60

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           ++ ALL+NR D+AVHS+KD+P E   GL L  +  R    D  +++    +  LP  SI+
Sbjct: 61  IQAALLDNRIDVAVHSLKDLPTEAVVGLRLAAVPARGADGDVLITSKASDVLGLPQESII 120

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GT S+RR+ QL   R D  IR +RGN+ TRL KLD+G YDAIILA AGL+RL L  RIR 
Sbjct: 121 GTGSMRRKAQLLHLRRDFQIRDIRGNLDTRLRKLDDGLYDAIILAEAGLRRLELIERIRH 180

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            +P    LPAVGQGA+G+E R  DS T  +LA LNH ++   V AER+M   L GGC  P
Sbjct: 181 VIPKAQMLPAVGQGALGLEIRERDSATAAMLAPLNHEDSHYSVLAERSMLRNLRGGCLAP 240

Query: 246 IGSYAELI--DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           +G++  +      ++L  +V + DG   +     G P  AE +G  +A++L   GA  ++
Sbjct: 241 VGAWGRIDPIKQLLFLDGVVVSGDGHHKVTASACGPPNRAEDIGRQVADQLAIQGAERLI 300

Query: 304 AEVYNGDA 311
           A      +
Sbjct: 301 AFARATGS 308


>UniRef50_C4ZFT9 Porphobilinogen deaminase n=1 Tax=Eubacterium rectale ATCC 33656
           RepID=C4ZFT9_EUBR3
          Length = 338

 Score =  342 bits (878), Expect = 1e-92,   Method: Composition-based stats.
 Identities = 113/309 (36%), Positives = 160/309 (51%), Gaps = 39/309 (12%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELE 67
           I TR S LAL Q  YV DKL  ++P    + V + T GD+     L K+G KG+FVKE+E
Sbjct: 5   IGTRGSKLALVQTDYVIDKLKRAYPDDDFKAVIIKTTGDLEQKKALDKIGSKGIFVKEIE 64

Query: 68  VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127
             LL  +  +AVHSMKD+P E   GL      +REDPRD  V  N  SLD LP G+++GT
Sbjct: 65  DELLSGKIHMAVHSMKDMPDEPAAGLTFAKAWKREDPRDVLVLKNAASLDELPHGAVIGT 124

Query: 128 SSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE------------------------ 163
            S RR+ QL + RPDL +  +RGN+ TRL KL +GE                        
Sbjct: 125 GSKRRKYQLLKLRPDLKVVGIRGNIDTRLRKLYDGEIIYEEVADNTVNNNEIANEKKNKY 184

Query: 164 ----YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAAL 219
                D I+LA AG+KR+G +S I      +  +PA  QG + +E R D+++    L AL
Sbjct: 185 SEYRLDGIVLAAAGIKRIGRDSEITQYFSEDDMIPAPAQGTLALELRADNAKLMAKLDAL 244

Query: 220 NHHETALRVTAERAMNTRLEGGCQVPIGSYAEL-----------IDGEIWLRALVGAPDG 268
           +  +T L    ER    ++ G C +P+ +Y ++            +  + L A+ G+ DG
Sbjct: 245 SDEKTNLCAGIEREFLKQIGGNCHLPVAAYCDIVSEKDRGNDSNKNNRLKLLAMFGSEDG 304

Query: 269 SQIIRGERR 277
            Q+ R E+ 
Sbjct: 305 KQLARTEQV 313


>UniRef50_A5CDH4 Porphobilinogen deaminase n=2 Tax=Orientia tsutsugamushi
           RepID=HEM3_ORITB
          Length = 298

 Score =  340 bits (874), Expect = 3e-92,   Method: Composition-based stats.
 Identities = 124/295 (42%), Positives = 161/295 (54%), Gaps = 3/295 (1%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           ++R+ +R S LAL QA  V  K+     GL   ++P+ T GD+I +  L  +GGKGLF+K
Sbjct: 2   IIRVGSRASRLALIQAQAVVQKINDL-LGLNAIIIPIKTTGDLIQNKNLYDIGGKGLFLK 60

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           E+E ALL N  DIAVHS+KDVP   P GL L  + ER D  D  VS   + +  LP G+I
Sbjct: 61  EIEYALLNNTIDIAVHSLKDVPAYLPDGLQLAAVLERGDVGDMLVSKIANKITDLPLGAI 120

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE-SRI 183
           VGTSS+RR+ QL   RPDL I   RGNV TR +K+ N E DA +LA AGL+RL  + SR 
Sbjct: 121 VGTSSVRRRIQLLMLRPDLNIVLFRGNVDTRWNKIINNEVDATVLAAAGLQRLNYDTSRF 180

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              +P    LPA+GQGA+ IE R DD     L A +NH  T   +  ER     L   C 
Sbjct: 181 CNIIPQSEMLPAIGQGAIAIEARKDDKLIMPLCAKINHQLTWQLIQVERGYLKTLNADCN 240

Query: 244 VPIGSYAELIDGE-IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           VPIG  A  I       + ++G  +       E RG  Q    +G+  A+     
Sbjct: 241 VPIGGIASYIGNNSFEAKFMLGDYNMRYFFYSEVRGKLQHGYDIGVEAAKNFQKR 295


>UniRef50_B3DZQ6 Porphobilinogen deaminase n=1 Tax=Methylacidiphilum infernorum V4
           RepID=B3DZQ6_METI4
          Length = 298

 Score =  339 bits (871), Expect = 7e-92,   Method: Composition-based stats.
 Identities = 114/296 (38%), Positives = 164/296 (55%), Gaps = 3/296 (1%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             L I +R S LAL QA  + D L   +P L +++  + T GD +   P+  +  +G+F 
Sbjct: 2   KPLIIGSRGSRLALIQAQLIVDSLKKEYPLLDIQIRVIKTTGDHLEAQPIRDIDQRGIFT 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KE+E  LLE   D+AVHS+KD+ VE    L +  I  REDPRD ++S  +    +L AG+
Sbjct: 62  KEIENKLLEGEIDLAVHSLKDLQVELHPRLVIAAIPPREDPRDCWISLQHPHPSSLQAGA 121

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG-EYDAIILAVAGLKRLGLE-- 180
           IV T S RR  QL  +RPDL I  +RGNV +RL KL    ++   +LA+AG+KRLG++  
Sbjct: 122 IVVTGSPRRANQLLRKRPDLRIVPVRGNVESRLRKLRENRQWQGTVLALAGIKRLGIDIS 181

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
           S     L  +  LPA GQGA+ ++ R++D  T+ L+  LN   TA  VTAER     L G
Sbjct: 182 SFFCTPLSMDWMLPAPGQGALALQARIEDKHTQSLVKHLNDFSTACAVTAERVFLHELGG 241

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
           GC+  +G+ AE+    + L  +       +   G+  G    AE +G  LA+ L N
Sbjct: 242 GCRTAVGARAEVEGSRLVLEGIWWPQQAIEPKEGKVVGEIHRAEDLGKKLADLLKN 297


>UniRef50_B8MVK7 Porphobilinogen deaminase, putative n=1 Tax=Talaromyces stipitatus
           ATCC 10500 RepID=B8MVK7_TALSN
          Length = 413

 Score =  339 bits (871), Expect = 7e-92,   Method: Composition-based stats.
 Identities = 120/337 (35%), Positives = 170/337 (50%), Gaps = 36/337 (10%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGL-VVELVPMVTRGDVILDTPLAKVG----- 57
             +R+ +R S +AL Q   V   L  +H G     +     +GD    +    +      
Sbjct: 72  KAVRVGSRNSKMALIQTSSVAAALYKAHHGFFTFPVSTHSVQGDRDKTSAFRDLAKAHGN 131

Query: 58  -------GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS 110
                   K L+  E+E  LL    D+ VHS+KDVP   P G  +     R DP DA + 
Sbjct: 132 KQTAADTAKSLWTLEIEARLLAGDIDLIVHSLKDVPTTLPDGCEIGAFPHRNDPTDALLV 191

Query: 111 N---NYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YD 165
                Y SL+ LPAGS+VGT S+RR  QL    P LII+  RGNV TR++KLD  +  Y 
Sbjct: 192 KAGLPYKSLEELPAGSVVGTCSVRRTAQLRHYCPHLIIQECRGNVDTRVAKLDANDSPYT 251

Query: 166 AIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETA 225
           AI++A AG+ RL LE RI   L       AVGQGA+GIE R +D + REL+A ++H  T 
Sbjct: 252 AIVVAAAGIVRLNLEHRITQRLSGPAYTYAVGQGALGIEIRKEDQKARELVACIDHWPTR 311

Query: 226 LRVTAERAMNTRLEGGCQVPIGSYAELI---------------DGEIWLRALVGAPDGSQ 270
           +R  AERA+   L+GGC  PIG ++  +               +G ++L   +  PDG  
Sbjct: 312 VRCLAERALLRFLQGGCSAPIGVHSAFVRTPAKGEPNVNDNHYEGTLYLTGTLLHPDGGM 371

Query: 271 IIRGERRGAP---QDAEQMGISLAEELLNNGAREILA 304
            IR   +G      D+E +G S+ +++L+ G  +IL 
Sbjct: 372 EIRAHEKGQVKCTADSETIGKSVGKKILDLGGAQILD 408


>UniRef50_B9L0Q4 Porphobilinogen deaminase n=2 Tax=Thermomicrobia (class)
           RepID=B9L0Q4_THERP
          Length = 560

 Score =  339 bits (870), Expect = 8e-92,   Method: Composition-based stats.
 Identities = 125/295 (42%), Positives = 163/295 (55%), Gaps = 4/295 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   +RI +R S LAL Q   V ++L    P   V +VP+VT GD    T L  +GG G+
Sbjct: 1   MAARIRIGSRGSTLALAQTEEVVERLRRLVPECSVTVVPIVTTGDRDRATSLTVLGGSGV 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F KEL  ALL    D+AVHS KD+P + P GL LV +  RED RD  V++    L  LPA
Sbjct: 61  FAKELHEALLAGTIDLAVHSAKDLPTQLPPGLVLVAVLAREDARDVLVTSPPRKLGELPA 120

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ VGTSS RRQ  L   RPDLI+  +RGNV TRL KL  G  DA++L  AGL+RL    
Sbjct: 121 GARVGTSSRRRQALLQRARPDLIVVDIRGNVDTRLRKLREGIVDALVLGAAGLRRLSQAD 180

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
            +   L P+  +PA GQGA+ +  R  D R  ELL+ L+       V  ERA       G
Sbjct: 181 LVAEYLDPDEFVPAPGQGALAVVARESDGRL-ELLSRLDEPLVHEAVAVERAFLAAFGSG 239

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDG---SQIIRGERRGAPQDAEQMGISLAEE 293
           C VP+G+YA +    +  R  V  PDG   SQ +   R  A + A ++G++LA  
Sbjct: 240 CSVPLGAYATIAGNRLRFRIAVLLPDGRFISQCLDWPREEAIERARELGLTLATR 294


>UniRef50_Q0BX92 Porphobilinogen deaminase n=1 Tax=Hyphomonas neptunium ATCC 15444
           RepID=HEM3_HYPNA
          Length = 321

 Score =  338 bits (869), Expect = 1e-91,   Method: Composition-based stats.
 Identities = 120/298 (40%), Positives = 166/298 (55%), Gaps = 7/298 (2%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPG-LVVELVPMVTRGDVILDTPLAKVGGKGLF 62
             LR+ TR SPLAL QAH + D + A+  G    E+V   T GD +    L   GGKGLF
Sbjct: 11  KRLRLGTRGSPLALAQAHQIADGIRAASAGAYDCEIVAFTTTGDKLTTERLINSGGKGLF 70

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122
            +EL+ AL     D+AVHS+KDVP   P G       +REDPRD F+S+   S+  LP G
Sbjct: 71  TRELDDALSRGELDLAVHSLKDVPSVLPPGQIFAAFPKREDPRDGFLSHGAKSIQDLPEG 130

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           + +GT+SLRR+ Q    RPDL + + RGNV TR+ KL+ G  DA  LA+AGL RLGL   
Sbjct: 131 ATLGTASLRREAQALALRPDLKVVTFRGNVATRMRKLEEGLADATFLAMAGLTRLGLSEV 190

Query: 183 IRAALPPEISLPAVGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
               +P E  LPA GQG +G+  R D D+   E+L  L+H  + +   AERA   +L+G 
Sbjct: 191 AT-PIPLEDMLPAAGQGIIGVVTRDDVDTELLEILGQLSHEPSRVAAIAERAFLEKLDGS 249

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQ----MGISLAEELL 295
           C+ PI ++      E  L   V +P G+   RG+        +     +G ++A+E++
Sbjct: 250 CRTPIAAHLFDRGDEWQLIGEVLSPGGTTRWRGDGVCRKDATDAQLVLLGRAVAQEII 307


>UniRef50_A2BL26 Probable porphobilinogen deaminase n=2 Tax=Thermoprotei
           RepID=HEM3_HYPBU
          Length = 303

 Score =  338 bits (869), Expect = 1e-91,   Method: Composition-based stats.
 Identities = 127/299 (42%), Positives = 168/299 (56%), Gaps = 3/299 (1%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            LR+ATR S L++ Q     + +    P L  ELV + TRGD+  D P   +GGKGLF K
Sbjct: 2   KLRVATRGSKLSIAQTMIALEAIKRVEPSLEYELVIVKTRGDIHQDKPFTAIGGKGLFEK 61

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY--DSLDALPAG 122
           E+ +A+LE RADIAVHS+KDVP     GL L     R+ P D  V       ++  LP+G
Sbjct: 62  EVNLAVLEGRADIAVHSLKDVPSAISPGLVLAMTPPRDPPYDVLVVRGGKEKTIWDLPSG 121

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
           +IVGTSS RR   L   R DL+ + LRGNV TRL KL+ G+YDAI+LA AGLKRLG++  
Sbjct: 122 AIVGTSSARRVAMLKHVRRDLVFKVLRGNVDTRLRKLEQGQYDAIVLAEAGLKRLGVDIE 181

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
               +PP+I  PA GQG +G+      S    +L   +  +      AERA      GGC
Sbjct: 182 YWR-IPPDILPPAPGQGIIGVYTLSSRSDILPILEKASDQKAMAEARAERAFLAYAGGGC 240

Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
             P+G+YAEL    ++  A + +PDGS+ +     G P    Q+G+  A EL    ARE
Sbjct: 241 HTPLGAYAELRGNTLYFHAALASPDGSRRVEVRVEGDPDKPTQVGLEAAFELRRLAARE 299


>UniRef50_B5G8F1 Porphobilinogen deaminase n=1 Tax=Streptomyces sp. SPB74
           RepID=B5G8F1_9ACTO
          Length = 314

 Score =  336 bits (863), Expect = 5e-91,   Method: Composition-based stats.
 Identities = 128/314 (40%), Positives = 172/314 (54%), Gaps = 13/314 (4%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR SPLAL Q   V   L    P L +E+VP+ T+ D      LA++GGKGLFV+E
Sbjct: 1   MRIGTRSSPLALAQVEQVSGLLRKFEPDLDIEVVPVTTKADKWQGD-LAQLGGKGLFVRE 59

Query: 66  LEVALLENRADIAVHSMKDVP--VEFPQGLGLVTICEREDPRDAFVSNNY---DSLDALP 120
           ++  L   + D+AVH MKDVP  V  P+GL       R+D RD  +        SL  LP
Sbjct: 60  IDQMLQRGQVDMAVHCMKDVPGDVPMPRGLIFAAYLPRDDVRDVLLVPEGSDVQSLAGLP 119

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD-----NGEYDAIILAVAGLK 175
            G+ V TS++RR+ Q+   RPDL +  +RG VG+R+ KLD     +   DA++LA AGL+
Sbjct: 120 PGASVATSAVRRKAQINRVRPDLNVVRVRGLVGSRIDKLDGRKPMDHMLDAMVLARAGLE 179

Query: 176 RLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235
           RL L  R R        LPAVG GA+G+ECR DD     LL  LN   T   +TAER M 
Sbjct: 180 RLDLMHRARQVFEVAEMLPAVGAGALGLECREDDDAVAYLLQQLNDEPTMTEITAERVML 239

Query: 236 TRLEGGCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRG-APQDAEQMGISLAEE 293
             L G C  PI  +     DG++ LR +V + DGS+ +     G +  D   +G  +  E
Sbjct: 240 HGLRGHCNSPIAGHCVTDPDGQLSLRGMVFSRDGSKFVHAHFWGESMNDPAVLGSRVCAE 299

Query: 294 LLNNGAREILAEVY 307
           LL  GAR+I+  + 
Sbjct: 300 LLRQGARDIIEGIP 313


>UniRef50_A4XK06 Porphobilinogen deaminase n=2 Tax=Clostridia RepID=HEM3_CALS8
          Length = 290

 Score =  336 bits (863), Expect = 5e-91,   Method: Composition-based stats.
 Identities = 101/293 (34%), Positives = 152/293 (51%), Gaps = 4/293 (1%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             LRI  R S L+  Q   V  K+     G+  E VP+ T+GD+     L      G+FV
Sbjct: 2   KKLRIGARDSKLSRIQVDIVARKIK-QTLGIECEFVPIKTKGDIDKTKSLKDFKSPGVFV 60

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KE+E+ALL    D+AVHS+KD+P E      +V + EREDPRD  VS +      L   +
Sbjct: 61  KEIELALLSREIDLAVHSLKDLPCEMDSNFEIVAVVEREDPRDVLVSKDGVGFYQLKPNA 120

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            +GTSSLRR+  L   R D+ + ++RGN+ TRLSK+++   D ++LA A LKRL L+S +
Sbjct: 121 KIGTSSLRREVHLKNLRQDIQVVNIRGNIETRLSKIESEGLDGVVLAYAALKRLNLDSHV 180

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
                     P  GQGA+ IEC  D    + +L+ +N  +  ++   ER +   L GGC 
Sbjct: 181 SYIFDVNEITPCPGQGAICIECLKDSPY-KNILSKINDADAYIQTQFERLVLKFLGGGCH 239

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
             IG + +    +I+  A + +  G ++I+    G   D   +   L+  L +
Sbjct: 240 SSIGVFCKTDQDKIYAFASILS--GDKLIKASIEGDKDDFLSLANKLSNMLKS 290


>UniRef50_C7NFP7 Hydroxymethylbilane synthase n=7 Tax=Actinomycetales
           RepID=C7NFP7_KYTSD
          Length = 358

 Score =  335 bits (861), Expect = 8e-91,   Method: Composition-based stats.
 Identities = 134/329 (40%), Positives = 180/329 (54%), Gaps = 33/329 (10%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
            V+R+ TR+S LA  Q+ +V D L A   G  VELV + T GDV    PL+++GG G+FV
Sbjct: 14  RVVRLGTRRSDLATTQSTHVADALRAR--GHEVELVLVTTEGDVNR-APLSRIGGTGVFV 70

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
             L  ALL    DIAVHS+KD+PV  PQ L +  + EREDPRDA V+ +  +L+ LPAG+
Sbjct: 71  SALRDALLAGEIDIAVHSLKDLPVAQPQELVIAAVPEREDPRDALVARDGLTLETLPAGA 130

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            VGT S RR+ QL   RPDL +  LRGNV  RL+ +  GE DA++LA AGL+RLGL   +
Sbjct: 131 RVGTGSPRREAQLRVARPDLEVVDLRGNVPRRLATVAEGELDAVVLAGAGLRRLGLTEHV 190

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              L P++ +PA GQGA+ +ECR DD+ +  +L  L+H  T    TAERA+   LE GC 
Sbjct: 191 TQWLEPQVMVPAPGQGALAVECRSDDAESIAMLEPLDHLPTRTATTAERAVLGTLEAGCS 250

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQII------------------------------R 273
            PIG+ A      + L    G  DGS+ +                               
Sbjct: 251 APIGALARHDGARVDLMTFAGPRDGSRALLEADCARGVPAGHPADTPDDTPADTPDDSRN 310

Query: 274 GERRGAPQDAEQMGISLAEELLNNGAREI 302
            +R      A ++G  +AE L   GA  +
Sbjct: 311 DDRVALDTAARELGRRVAEALRGGGADVL 339


>UniRef50_Q09899 Porphobilinogen deaminase n=2 Tax=Schizosaccharomyces
           RepID=HEM3_SCHPO
          Length = 336

 Score =  335 bits (861), Expect = 8e-91,   Method: Composition-based stats.
 Identities = 126/314 (40%), Positives = 176/314 (56%), Gaps = 16/314 (5%)

Query: 8   IATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG---GKGLFVK 64
           I TR+S LA+ Q+  ++++L   +P L   ++   T GD IL   L +      K L+ +
Sbjct: 9   IGTRKSKLAVIQSEIIREELEKHYPHLEFPIISRDTIGDEILSKALFEFKRQLAKSLWTR 68

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALPA 121
           ELE  L+ N+  I VHS+KD+P E P G+ +  I +R  P DA V     +Y ++  LP 
Sbjct: 69  ELEALLVTNQCRILVHSLKDLPSEMPDGMVIACIPKRSCPLDAIVFKAGSHYKTVADLPP 128

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAGLKRLGL 179
           GS+VGTSS+RR+  LA   P L    +RGNVGTRL+KLD  +  +D ++LA AGL RLGL
Sbjct: 129 GSVVGTSSIRRRALLARNFPHLRFVDIRGNVGTRLAKLDAPDSQFDCLVLAAAGLFRLGL 188

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
           + RI   L       AVGQGA+ +E R DD    E+L  L H ET     AERA+  RL+
Sbjct: 189 KDRIAQMLTAPFVYYAVGQGALAVEVRADDKEMIEMLKPLQHQETLYACLAERALMKRLQ 248

Query: 240 GGCQVPIGSYAEL-----IDGEIWLRALVGAPDGSQIIRGE---RRGAPQDAEQMGISLA 291
           GGC +PIG   ++         I L   V + DG +   G       + ++AE++GI++A
Sbjct: 249 GGCAIPIGVQTDVLAISNSSYRISLLGTVLSADGLRAAFGNAEAVVSSEEEAEELGITVA 308

Query: 292 EELLNNGAREILAE 305
             LL NGA  IL E
Sbjct: 309 LALLKNGAGPILEE 322


>UniRef50_C8WIZ2 Porphobilinogen deaminase n=2 Tax=Coriobacteriaceae
           RepID=C8WIZ2_EGGLE
          Length = 327

 Score =  334 bits (857), Expect = 3e-90,   Method: Composition-based stats.
 Identities = 137/318 (43%), Positives = 183/318 (57%), Gaps = 13/318 (4%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR S LALWQAH+V D L A+ PG+ V +  + T+GD IL   L+K+G KGLF KE
Sbjct: 4   MRIGTRGSKLALWQAHHVADLLRAASPGMDVSVEVVKTKGDRILGVALSKIGDKGLFTKE 63

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           LE AL + R D+ VHSMKDVP   P+GL L     R D RD  V+ +  +   LPAGS V
Sbjct: 64  LEQALFDGRVDVCVHSMKDVPTALPEGLALAGCLIRADARDVLVAASGTTFAGLPAGSRV 123

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GT +LRR  QL   R DL    +RGN+ TR++K+ +G  DA++LA AG++R+G  + +  
Sbjct: 124 GTGALRRLSQLRAVRDDLDYVEVRGNLDTRIAKVRDGALDAVVLAAAGIERMGWSAEVAE 183

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
           A   +  +PAVGQGA+G+E R DD RT    A +    T   V AER +   L+GGCQVP
Sbjct: 184 AFSVDTVVPAVGQGAIGLEVRADDERTARACAQVRCAATDACVAAERHVMRALDGGCQVP 243

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGE-------------RRGAPQDAEQMGISLAE 292
           IG+YA   +G + L A VG+ DGS ++R                  A ++A  +     E
Sbjct: 244 IGAYARYEEGLLVLDAFVGSLDGSHVLRSRLSAASQPPNDTDAVEAAVREARALAQRAVE 303

Query: 293 ELLNNGAREILAEVYNGD 310
           E    GAR +L  V    
Sbjct: 304 EFEAQGARAVLDAVRAAG 321


>UniRef50_A8SQW4 Putative uncharacterized protein n=1 Tax=Coprococcus eutactus ATCC
           27759 RepID=A8SQW4_9FIRM
          Length = 350

 Score =  334 bits (857), Expect = 3e-90,   Method: Composition-based stats.
 Identities = 115/314 (36%), Positives = 164/314 (52%), Gaps = 26/314 (8%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62
              +++ TR S LAL Q   V   L    P +  ++V M TRGD      L + GGK +F
Sbjct: 39  KKTVKVGTRGSKLALAQTELVIKALNERFPQIDFQMVTMSTRGDRDTSRALLEFGGKAVF 98

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122
           V+E E A+L+   DIAVHS KD+P+E  +GL +     R  P+D F+  +  S D     
Sbjct: 99  VEEFEEAILKGDIDIAVHSAKDMPMEIMEGLTISGTLPRACPQDVFIYKSGRSFDR-NDS 157

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL--- 179
            +VGTSSLRRQ Q+ +  P+ + ++LRGNVGTR+ KL++GEYDAIILA AGL+RLG+   
Sbjct: 158 FVVGTSSLRRQYQIRDMYPNAVCKNLRGNVGTRIQKLEDGEYDAIILAAAGLERLGVIED 217

Query: 180 -------------ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETAL 226
                        +      L  E  LPA  QG + IE R       +++ A+N  E   
Sbjct: 218 KGNDSTECFEVHKDELTFRYLSTESMLPAACQGIIAIETRTSGEAY-DMVRAINDTEAYT 276

Query: 227 RVTAERAMNTRLEGGCQVPIGSYAELIDGEIWL---RALVGAPDGSQ-----IIRGERRG 278
           ++T ERA+ +RL  GC  PIG Y+EL    + L   +    + D  +     I R    G
Sbjct: 277 QLTCERAVLSRLNAGCHEPIGVYSELKGKHMKLSLMKVDAASSDKEKDEEIQIHRKTVEG 336

Query: 279 APQDAEQMGISLAE 292
              + EQ+  +L +
Sbjct: 337 NTSEWEQLVEALIK 350


>UniRef50_A8MGE4 Porphobilinogen deaminase n=30 Tax=cellular organisms
           RepID=HEM3_ALKOO
          Length = 296

 Score =  333 bits (856), Expect = 4e-90,   Method: Composition-based stats.
 Identities = 113/293 (38%), Positives = 160/293 (54%), Gaps = 5/293 (1%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            +R+ +R+S LA+ Q+  V + +    P + +ELV M T GD+ LD  L K+GGKGLF+K
Sbjct: 2   KIRVGSRESKLAVKQSEIVIEAIRKYDPNIEIELVTMKTTGDIKLDQTLDKIGGKGLFIK 61

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           EL+ AL ++R DI VHS KD+P+   + L +V + +REDPRD  V     ++        
Sbjct: 62  ELDQALYDDRVDITVHSFKDMPMAIDEYLPIVAVSKREDPRDVLVLPK--TVKEPDFSKP 119

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +G SS RR+ QL E  P   +  +RGNV TRL KLD GE+ AI LA+AGLKRLGLE RI 
Sbjct: 120 IGCSSFRRKIQLQEIYPHCSVEPIRGNVLTRLEKLDRGEFSAITLALAGLKRLGLEERIS 179

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
                   LPA  QG + ++ R         L+  +  E      AER+    L GGC  
Sbjct: 180 RIFEVTEILPAACQGVIVVQARKG--FDVSFLSDFHDKEAWDISMAERSFVRTLNGGCSS 237

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           P+ +Y E+ D  + L  L      S + +    GA +  E+MG +LA ++   
Sbjct: 238 PVAAYGEIKDNYLTLTGLYVDSSNS-VHKKTITGARKQGEEMGFNLALQMKGE 289


>UniRef50_B9XN63 Porphobilinogen deaminase n=1 Tax=bacterium Ellin514
           RepID=B9XN63_9BACT
          Length = 332

 Score =  332 bits (853), Expect = 7e-90,   Method: Composition-based stats.
 Identities = 127/329 (38%), Positives = 172/329 (52%), Gaps = 38/329 (11%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGG---K 59
           +  + IATR S LAL QA+ V  +  ++ P L +EL  + T GD +    LAK G    K
Sbjct: 6   NKPIFIATRGSALALAQANAVLSQCRSAFPKLDIELKIIKTTGDKLQKASLAKEGESLPK 65

Query: 60  GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSL--- 116
           GLF KELEVALL   ADIAVHS+KD+P E P GL L  + +R D RD  V  + + L   
Sbjct: 66  GLFTKELEVALLNGDADIAVHSLKDLPTELPTGLILGAVSKRADVRDVLVYRDAEYLRSQ 125

Query: 117 ---------------DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN 161
                             P G+ V TSS RR+ QL  +R DL +  +RGNV TRL KL N
Sbjct: 126 PGKSNRRGFTPKLAIKDFPPGATVATSSTRRKAQLLAQRGDLNVVEIRGNVATRLEKLAN 185

Query: 162 -GEYDAIILAVAGLKRLGL--------------ESRIRAALPPEISLPAVGQGAVGIECR 206
             E DA +LA AGL+RL                E  +   L  ++ LP VGQ A+G+E R
Sbjct: 186 QPELDATVLAAAGLERLNFKITAEGKLAGEGIPEGLLATILDFDVMLPCVGQAALGMEIR 245

Query: 207 LDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAP 266
            +D+R +E+   LNH ET   V AER+  + + GGCQ P+ +YAE+   ++ +RA     
Sbjct: 246 ENDARIQEICDRLNHPETHACVLAERSFLSGMGGGCQSPVAAYAEIAGDQLQMRAASFRE 305

Query: 267 DGSQIIRGERRGAPQDAEQMGISLAEELL 295
             +   R     +  +A  +G  LA +L 
Sbjct: 306 --TSARRAVGGKSINEAVALGQELAAKLK 332


>UniRef50_A4QB59 Porphobilinogen deaminase n=15 Tax=Corynebacterium RepID=HEM3_CORGB
          Length = 302

 Score =  332 bits (853), Expect = 9e-90,   Method: Composition-based stats.
 Identities = 118/304 (38%), Positives = 171/304 (56%), Gaps = 8/304 (2%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            L+I TR S LA  QA  ++D+L   + G   EL  + T GDV + +P+ ++G  G+F +
Sbjct: 2   TLKIGTRGSKLATTQAGTIRDQLK--YFGRDAELHIVTTPGDVNM-SPVERIG-VGVFTQ 57

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
            L   L     D+AVHSMKD+P        LV +  R D R+A ++ +  +L  LP G+ 
Sbjct: 58  ALRDVLHAGECDVAVHSMKDLPTAADPRFHLV-VPTRADSREALIARDGLTLAELPEGAK 116

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGTS+ RR  QL   RPDL I  LRGN+ TR+ K+ +GE DA++LA AGL R+G++ R  
Sbjct: 117 VGTSAPRRISQLKAIRPDLEILPLRGNIDTRMGKVTSGELDAVMLAYAGLTRVGMQDRAT 176

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
                +I +PA  QGA+ IECR DD+ T   L  L H +T +   AER +  RLE GC  
Sbjct: 177 EVFDADIIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVLNRLEAGCTA 236

Query: 245 PIGSYAELI---DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           P+ ++A L       + L A V A DGS  +     G     E++G  +A++L++ GA  
Sbjct: 237 PVAAHATLDGYSGDTMTLTAGVYALDGSDQLVFSAEGDGARPEELGELVAQQLIDAGAAN 296

Query: 302 ILAE 305
           +L +
Sbjct: 297 LLGD 300


>UniRef50_Q82P95 Porphobilinogen deaminase 2 n=14 Tax=Actinomycetales
           RepID=HEM32_STRAW
          Length = 314

 Score =  332 bits (852), Expect = 1e-89,   Method: Composition-based stats.
 Identities = 124/305 (40%), Positives = 167/305 (54%), Gaps = 4/305 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI +R SP+AL Q   V+ +L A HP    E+V + T GD  +   L+KV GKG F KE
Sbjct: 10  IRIVSRDSPMALAQVARVRAELAALHPRTRTEVVAVKTTGDKWMGD-LSKVDGKGAFTKE 68

Query: 66  LEVALLENRADIAVHSMKDVPV--EFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           ++ ALL   AD+AVH +KDVP     P G       +R+D RDA V     +LD LP G+
Sbjct: 69  VDAALLAGEADLAVHCVKDVPADRPLPAGTMFAAFLKRDDIRDALVHPGGLTLDELPPGT 128

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            +GTSS+RR  QLA   P L     RGN   RL KL  GE DA++LAV+GL+R+G E  I
Sbjct: 129 RIGTSSVRRVAQLAAAYPHLECVPFRGNANRRLEKLAAGEADALLLAVSGLERIGREDVI 188

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              L PE  +P +G G + ++CR  D+   E ++ L    T    TAER     L+G C 
Sbjct: 189 TEVLEPETMMPPIGAGILALQCREGDTGLIETISELGDPGTHREATAERMFLHVLQGHCN 248

Query: 244 VPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302
            PI  YA    +GE+ LRA V   DG  ++         D   +G S+A  LL  GARE+
Sbjct: 249 SPIAGYARTERNGELSLRASVFTLDGKTVLNAHEWAGRLDPATLGTSVAVALLRQGAREL 308

Query: 303 LAEVY 307
           + ++ 
Sbjct: 309 IDDIP 313


>UniRef50_C1F251 Hydroxymethylbilane synthase n=1 Tax=Acidobacterium capsulatum ATCC
           51196 RepID=C1F251_ACIC5
          Length = 312

 Score =  332 bits (851), Expect = 1e-89,   Method: Composition-based stats.
 Identities = 139/322 (43%), Positives = 176/322 (54%), Gaps = 37/322 (11%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLA----KVGGKGL 61
           +RI +R S LALWQA+++  +L     G  V +  + T GD +     A    ++GGKG+
Sbjct: 2   MRIGSRGSQLALWQANHIAARLRTL--GHEVTIEIIRTTGDALQHVTFAKVSTELGGKGI 59

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F KE+E AL E R D+AVHS+KD+P +      L  I ER DPRDA +S  Y SL +LP 
Sbjct: 60  FTKEIEEALREGRIDLAVHSLKDLPTDLDPAFTLAAIPERVDPRDALLSARYTSLASLPH 119

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ VGTSS RR+ QL   R DL  +  RGNV TR+ K+  G+ DAIILA AGL+RLGL  
Sbjct: 120 GACVGTSSERRRAQLLVHRSDLRFQEFRGNVDTRIRKMVEGQADAIILASAGLERLGLTE 179

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
             R  L PEI  PA GQGA+ IE R DD+ T  +LA+L+H  T   VTAER     L GG
Sbjct: 180 YRRECLAPEILCPAAGQGALAIETRADDAETLAILASLDHSATRYAVTAERTALASLGGG 239

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ-------------------- 281
           CQVPIG +           A V   DG+  I+G   GA                      
Sbjct: 240 CQVPIGIHC----------APVPGADGAYAIQGVVAGAAAKAASSAAHPVIRVAFEHQQG 289

Query: 282 -DAEQMGISLAEELLNNGAREI 302
              + +G  LAEELL  GA+  
Sbjct: 290 LSPQALGRQLAEELLRQGAQPF 311


>UniRef50_Q8TXC8 Probable porphobilinogen deaminase n=1 Tax=Methanopyrus kandleri
           RepID=HEM3_METKA
          Length = 298

 Score =  332 bits (851), Expect = 1e-89,   Method: Composition-based stats.
 Identities = 120/299 (40%), Positives = 172/299 (57%), Gaps = 3/299 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHP-GLVVELVPMVTRGDVILDTPLAKVGGKG 60
           +   +R+ATR S LA+ Q   V + L    P  + VE+V   +RGDV+ D PL K+G KG
Sbjct: 1   MSETIRVATRSSRLAIIQTREVIELLERESPRDVEVEIVKTKSRGDVVRDRPLHKLGEKG 60

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           +FVKE++  +LE +ADIAVHS KDVP      + +  +  R DPR+  VS +   L  LP
Sbjct: 61  VFVKEVDRLVLEGKADIAVHSAKDVPSVVDYPVDVAAVPPRRDPRECLVSRHGG-LKELP 119

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ VGTSS RR+ Q+   RPDL +  +RGNV TR+SK+   EYDA +LA  GL RLG+ 
Sbjct: 120 RGATVGTSSPRRRAQILLERPDLKVEPMRGNVDTRVSKVRRREYDAAVLAKVGLDRLGMT 179

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
           S +     PE  +P  GQGA+ I CR DD R + LL  ++  ++ + V  E+A+   L  
Sbjct: 180 SEVSEVYDPEEFVPPAGQGALMITCRKDDDRVKRLLEVVDDEKSRVEVETEKAVVRELGV 239

Query: 241 GCQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
           GC  P+G +        + L   +   DGS     + RG+P+D  +  +S A E+L++G
Sbjct: 240 GCSEPVGVHVRARDGDHVRLVLGLFEEDGSCGHVLKMRGSPEDVVREAVSQAREVLSDG 298


>UniRef50_A0DD68 Chromosome undetermined scaffold_46, whole genome shotgun sequence
           n=2 Tax=Paramecium tetraurelia RepID=A0DD68_PARTE
          Length = 306

 Score =  331 bits (850), Expect = 2e-89,   Method: Composition-based stats.
 Identities = 124/312 (39%), Positives = 171/312 (54%), Gaps = 13/312 (4%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTR-GDVILDTPLAKVGGKG 60
           +   LRIATR S LA+ Q +YV  +L         E++ +    GDV L  PL ++   G
Sbjct: 1   MQRQLRIATRSSALAMAQTNYVISELKQ-----ECEIIKVSNEVGDVNLQDPLYQMPTVG 55

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLD 117
           +F K++E  LLE +AD+AVHS+KD+P      L L    + E   D  + N    Y SL 
Sbjct: 56  VFTKQVEQYLLEQKADVAVHSLKDLPTIIDAQLHLAAYTKFEQRGDVVLLNKKYNYKSLS 115

Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177
            LP G  VGTSSLRR   +  R P L + ++RGN+ TR+ KLD G+YDAIILA AG+ RL
Sbjct: 116 ELPDGLKVGTSSLRRIATIRSRYPKLNLINIRGNLNTRIQKLDEGQYDAIILAKAGILRL 175

Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237
           GL  +I   L  +  L A  Q A+GI+CR DD  T   L  LN  +   R  AER     
Sbjct: 176 GLAEKISFDLDEKEFLYAPAQAALGIQCRKDDLETIGRLQILNDTDAQKRCVAERMFLNL 235

Query: 238 LEGGCQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
           LEGGC++PI  Y+E   DG+++++  V A DGS++I  E        E +G  L E++  
Sbjct: 236 LEGGCRLPIAVYSECREDGQVYIKGRVLAVDGSKVIEDEA---LDHFEIVGQILCEKIKV 292

Query: 297 NGAREILAEVYN 308
            G  E++  +  
Sbjct: 293 LGGVELIESLKQ 304


>UniRef50_B8GXG1 Porphobilinogen deaminase n=8 Tax=Caulobacteraceae RepID=HEM3_CAUCN
          Length = 322

 Score =  331 bits (850), Expect = 2e-89,   Method: Composition-based stats.
 Identities = 132/315 (41%), Positives = 176/315 (55%), Gaps = 17/315 (5%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMAS----------HPGLVVELVPMVTRGDVILDTPLA 54
            +RI  R S L+L Q+  ++ ++  +                 L+P+VT GD I D  L 
Sbjct: 6   PIRIGARGSKLSLAQSGLMQARIAHALGVPAGASKDEIEAAAPLIPIVTSGDRIQDRRLM 65

Query: 55  KVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD 114
           ++GGKGLF KE+E ALL+ R D AVHS+KD+P E P GL L    EREDPRDAF+S+  +
Sbjct: 66  EIGGKGLFTKEIEEALLDGRIDCAVHSLKDMPAELPPGLVLAATPEREDPRDAFISHVCE 125

Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174
            L+ LP G+ +GT+SLRRQ Q    RPDL I  LRGNV TRL+KL+ GE DAI+LA +GL
Sbjct: 126 RLEDLPKGARLGTASLRRQAQALHVRPDLEIVMLRGNVDTRLAKLERGEADAILLAQSGL 185

Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234
            RLGL    R+ L P+   PA GQGA+ IE R +D      L A+   +T + V AER  
Sbjct: 186 NRLGLGHLTRSWLDPDACPPAPGQGALVIETRAEDIG-APWLEAVRCRQTTIAVAAERGA 244

Query: 235 NTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGA------PQDAEQMGI 288
              LEG C+  IG+ A L    + +      PDG+Q  R E            +A   G+
Sbjct: 245 LLALEGSCRTAIGARAILDGARLSMIVEALTPDGAQRFRREGDITLTGADDIAEARAFGL 304

Query: 289 SLAEELLNNGAREIL 303
           +L  E+   G   I+
Sbjct: 305 TLGAEVRAAGGDAII 319


>UniRef50_B0D5Q2 Predicted protein n=1 Tax=Laccaria bicolor S238N-H82
           RepID=B0D5Q2_LACBS
          Length = 340

 Score =  331 bits (850), Expect = 2e-89,   Method: Composition-based stats.
 Identities = 118/316 (37%), Positives = 172/316 (54%), Gaps = 10/316 (3%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62
              + I  R S LA  QA  V+ +L    P    E+         I  + + + GG  L+
Sbjct: 16  QKAIVIGCRPSTLAKIQAELVRSRLKVLFPASRFEISSKKFPQPEIGTSQITERGGASLW 75

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLDAL 119
             ELE AL +   DI VHS+KDVP +  +G  ++ + ERED RD  V  +     +L+ L
Sbjct: 76  TTELEDALFDGDIDILVHSLKDVPTKLKEGCEIIHVLEREDRRDCLVVKDGLPYRTLEEL 135

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAIILAVAGLKRL 177
           PAGS+VGT S+RR  Q+  R P L+I+ +RGN+ TRL KLD+ +  Y A+ILA AGL RL
Sbjct: 136 PAGSVVGTGSVRRVAQMKRRYPLLVIKDVRGNIDTRLQKLDSPDLPYTALILASAGLLRL 195

Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237
            L  RI + L P IS PAVGQG +G E R  D++ + +++ L   +    V AERA+   
Sbjct: 196 SLHDRITSYLSPPISYPAVGQGCLGAEFRSADTKVKAMVSRLEVWQDGWAVRAERALLWV 255

Query: 238 LEGGCQVPIGSYAELIDGEI--WLRALVGAPDGSQIIRGERRG---APQDAEQMGISLAE 292
           LEGGC  P+G ++      I     +++ +PDGS+ I  E  G   + ++  ++G   A 
Sbjct: 256 LEGGCAFPVGIWSSWSGDNIASESLSVMTSPDGSEEITVETTGVVASVEEVLELGKQAAR 315

Query: 293 ELLNNGAREILAEVYN 308
            LL  G R I+ ++  
Sbjct: 316 SLLEKGGRGIIVDLRA 331


>UniRef50_D0J8N1 Porphobilinogen deaminase n=2 Tax=Blattabacterium
           RepID=D0J8N1_BLASP
          Length = 310

 Score =  331 bits (849), Expect = 2e-89,   Method: Composition-based stats.
 Identities = 99/312 (31%), Positives = 153/312 (49%), Gaps = 7/312 (2%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           ++ ++RI TR SPLA+ QA  V+  L     G    L  + + GD+I + PL K    G+
Sbjct: 1   MNKIIRIGTRNSPLAISQAIEVQKVLHRL--GYCSHLFFIKSEGDLIQNIPLYKFKKVGI 58

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS-LDALP 120
           F + L   LL  + D+AVHS+KDVP   P+ + L    +R    D  +     + L    
Sbjct: 59  FTRNLTDVLLSGKIDMAVHSLKDVPTSLPEKIVLSAYLKRGSFSDLLIYQGSSNFLLNSK 118

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
             +++ T SLRR+     R P   I  LRGN+ TRL KL N  +   I A  GL+RLGL 
Sbjct: 119 IEAVIATGSLRRRAFWKNRYPHHTIVDLRGNINTRLKKLYNNSWKGAIFAKVGLERLGLL 178

Query: 181 SRIRAALP--PEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
           + +        +  +P+ GQG + +  R D+     L   L+   T L    ER     L
Sbjct: 179 NDLEGFNFKVLDWMIPSPGQGIIVVSTRKDNEWIHYLTKELDDRNTRLSANIERQFLKTL 238

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
            GGC  PIG++A + +  I+   ++ + DG Q IR ++ G   +   +G   A+E+L  G
Sbjct: 239 GGGCVTPIGAHAIIKNKIIYFTGILFSLDGMQKIRKKKIGT--NYNVIGYQCAKEILEEG 296

Query: 299 AREILAEVYNGD 310
            ++IL  +   +
Sbjct: 297 GKKILENMRIKN 308


>UniRef50_C6XKH7 Porphobilinogen deaminase n=1 Tax=Hirschia baltica ATCC 49814
           RepID=C6XKH7_HIRBI
          Length = 323

 Score =  330 bits (848), Expect = 3e-89,   Method: Composition-based stats.
 Identities = 110/299 (36%), Positives = 152/299 (50%), Gaps = 7/299 (2%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPG-LVVELVPMVTRGDVILDTPLAKVGGKG 60
              +++I  R SPLA+ QA     +        + +E+    T GD +LD  L   GGKG
Sbjct: 17  STQIVKIGARGSPLAVQQAEDFAARFKEIVGNTVEIEIHTFTTSGDQLLDKRLQDAGGKG 76

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LF +EL++A L  R DI VHS+KDVP   P GL +     REDPRDA       ++  LP
Sbjct: 77  LFTRELDIAQLSGRIDIVVHSLKDVPTVLPDGLQMGCYLPREDPRDALFGKVG-NIKDLP 135

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ +GT+SLRR  Q    RPDL I   RGNV TRL KL+ G+ DA +LA AGL RLG+ 
Sbjct: 136 HGATLGTASLRRSAQALALRPDLKIVMFRGNVQTRLRKLEEGQADATLLAAAGLNRLGMT 195

Query: 181 SRIRAALPPEISLPAVGQGAVGIE-CRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
            +    +P E  LPA GQG V        +    +    ++  E+ +   AERA   RL+
Sbjct: 196 DKAAGFMPKEEMLPACGQGIVCTTLTNNAEDWIFKACLQIDVLESRIAAIAERAFLKRLD 255

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRG----APQDAEQMGISLAEEL 294
           G C+ PI  +    +  + +R  V A DGS+    +           A  +G  L E++
Sbjct: 256 GSCRTPIAGHLSFNETGVDMRGEVLADDGSKRWFSQMSLDTIPDENQAASLGFELGEKV 314


>UniRef50_B6W7F3 Putative uncharacterized protein n=1 Tax=Anaerococcus hydrogenalis
           DSM 7454 RepID=B6W7F3_9FIRM
          Length = 318

 Score =  330 bits (846), Expect = 5e-89,   Method: Composition-based stats.
 Identities = 103/309 (33%), Positives = 155/309 (50%), Gaps = 12/309 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           ++I +R S LAL QA+ VKD L     GL  ++V + T+GD I D  + ++  KG+FV+E
Sbjct: 2   IKIGSRASKLALIQANMVKDILEKE--GLEAQIVEISTKGDRIRDRKIDQLNSKGVFVRE 59

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN-YDSLDALPAGSI 124
           +E  LL+   DIAVHS+KD+P +    L      + EDPRD FV  + +  +D L   ++
Sbjct: 60  IEEKLLDKTIDIAVHSLKDMPSQIDDRLIFTPPLKGEDPRDCFVGKDVFKKMDDL-NNAL 118

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGT S RR CQ      ++  +++RGNV TR+ K+ +   D +ILA +GL R GL+  I 
Sbjct: 119 VGTGSNRRVCQGKNHFSNIKFKAIRGNVETRIKKVQSENLDGVILAKSGLIRAGLDGEIN 178

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L P I  P+  QG +GIE R +D +  E+    +  +T  R+  ERA    L   C  
Sbjct: 179 FDLDPHIFTPSPCQGILGIEIRKEDKKLFEIFKKNSDEKTLFRMETERAFQKELGADCST 238

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304
           P+G + E+   +I L   +      +I      G   +   +   LA  L          
Sbjct: 239 PMGIFTEIDHDKITLTGSMAFDKDDRINYERVSGNISERIHLAQKLARTLKKK------- 291

Query: 305 EVYNGDAPA 313
             Y  + P 
Sbjct: 292 -SYKKNNPC 299


>UniRef50_Q7UPN0 Porphobilinogen deaminase n=1 Tax=Rhodopirellula baltica
           RepID=HEM3_RHOBA
          Length = 337

 Score =  330 bits (846), Expect = 5e-89,   Method: Composition-based stats.
 Identities = 127/332 (38%), Positives = 182/332 (54%), Gaps = 27/332 (8%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62
              LRIATR+SPLA+WQA +V   L     G   E+VP+V++GD  +  P+      GLF
Sbjct: 9   TTRLRIATRESPLAMWQAEHVAKLLKKH--GFQTEIVPLVSKGDTDM-RPIDGTRQVGLF 65

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS------- 115
            K ++ AL+++ AD+AVHS+KD+P E      L  +  RE   DA V  +          
Sbjct: 66  TKRIQQALVDDEADVAVHSLKDLPTEPDSRFVLAAVPPRESVLDALVFADNSPHLESQTG 125

Query: 116 ----LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAV 171
               LD LP G+ VGT S RR  QL + RPDL +  +RGNV TRL+KL+ GE+DAI+LA 
Sbjct: 126 AESPLDYLPQGARVGTGSTRRLAQLKQLRPDLEVLPIRGNVQTRLAKLNAGEFDAIVLAH 185

Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231
           AG+ RL +        P +  +PA GQGA+GIE R DD+   + +A LN     L  TAE
Sbjct: 186 AGILRLEMTDLPHRLFPLDEMIPAPGQGALGIEVRSDDAGAMDAIANLNDAAARLAATAE 245

Query: 232 RAMNTRLEGGCQVPIGSYAELI----DGEIWLRALVGAPDGSQIIRGERRGA-------- 279
           R + + L GGC  PI  +A+L       E+ LRA+V + DG Q ++ + R          
Sbjct: 246 RKVLSELHGGCLAPIACHAKLETSNHGTELCLRAIVMSADGEQRLQEDARITVQPNDADL 305

Query: 280 -PQDAEQMGISLAEELLNNGAREILAEVYNGD 310
              +A ++G  +A+ L + GA ++++ V    
Sbjct: 306 HVAEAHELGTLVAKRLRDKGADKLISTVRENH 337


>UniRef50_B2IAW6 Porphobilinogen deaminase n=4 Tax=Alphaproteobacteria
           RepID=B2IAW6_BEII9
          Length = 337

 Score =  328 bits (842), Expect = 1e-88,   Method: Composition-based stats.
 Identities = 138/306 (45%), Positives = 179/306 (58%), Gaps = 5/306 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASH--PGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           LR+ TR SPLAL QAH + D+L  +H      V +  + T GD+I D PL+  GGKGLF 
Sbjct: 19  LRLGTRGSPLALAQAHELADRLARAHGFAKEAVAITIIRTSGDMIQDRPLSLAGGKGLFT 78

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KEL+ AL+E   D+AVHS KD+P   P+ L +     RED RD ++S        LP GS
Sbjct: 79  KELDQALIEGMVDLAVHSAKDLPTILPEDLIIAGYLPREDVRDVWISPKAGHPRDLPPGS 138

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           +VGT+SLRR   L   RPDL +R LRGNV TRL+KL  GE DA +LA+AGL+RLGL  + 
Sbjct: 139 VVGTASLRRGALLKRLRPDLEVRLLRGNVETRLAKLAAGEVDATLLALAGLRRLGLADKA 198

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
              L  E  LPA GQGA+GI  R DD+ T  LLA +    T + + AER   T L+G C+
Sbjct: 199 TQVLAIEDFLPAAGQGAIGITTRRDDAATLALLAPILDPATHVALAAERGFLTVLDGSCK 258

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
            PIG++A +   ++ LR +V  PDGS+       G  +      +  A EL    AR IL
Sbjct: 259 TPIGAHATVEHDQVTLRGIVLRPDGSEWFEACESGPLESGS---LEAARELGETAARAIL 315

Query: 304 AEVYNG 309
           A +  G
Sbjct: 316 ARLPEG 321


>UniRef50_Q46CH0 Probable porphobilinogen deaminase n=7 Tax=Euryarchaeota
           RepID=HEM3_METBF
          Length = 316

 Score =  328 bits (842), Expect = 2e-88,   Method: Composition-based stats.
 Identities = 113/304 (37%), Positives = 164/304 (53%), Gaps = 7/304 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG-GKGLFVK 64
           + I TR S LAL QA  V   L A   G+   L  + T GD   D PL  V  G G FV+
Sbjct: 1   MIIGTRGSQLALAQAETVARLLKAK--GVETSLKIIKTSGDRFTDRPLHAVSSGVGAFVR 58

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           EL+  +LE + DIAVHSMKD+P   P  L  V + +R+ P D  ++ +   LD L   SI
Sbjct: 59  ELDEVMLEGKIDIAVHSMKDMPTIRPPTLPTVAVLKRDTPFDLLLTYDGTPLDELSEQSI 118

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GTSSLRR  Q+   RPDL+ + LRGN+ TRL KL  G+YD I+LA AGL+R+G E    
Sbjct: 119 IGTSSLRRAAQIKRYRPDLVTQDLRGNIDTRLRKLKEGKYDGILLAKAGLERMGWELE-G 177

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L P+   P+  QG + +  R + +     ++ L+H ++ +    ER + + L GGC  
Sbjct: 178 EILSPDFFCPSPNQGTIAVVTRAE-TEAEAAVSRLDHTDSRIATEIERILISELGGGCTT 236

Query: 245 PIGSYAELIDG--EIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREI 302
           PIGSYAE++    ++ +RA V + DG + +            +    L   L++ G +++
Sbjct: 237 PIGSYAEIMPDRKKLHVRAEVLSLDGEETVGINEFIPMAGGIEKARELGSSLVHMGGKKL 296

Query: 303 LAEV 306
             E 
Sbjct: 297 ADEA 300


>UniRef50_C4QMG7 Hydroxymethylbilane synthase (Porphobilinogen deaminase, putative)
           n=1 Tax=Schistosoma mansoni RepID=C4QMG7_SCHMA
          Length = 411

 Score =  327 bits (839), Expect = 3e-88,   Method: Composition-based stats.
 Identities = 117/302 (38%), Positives = 160/302 (52%), Gaps = 25/302 (8%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           NV+R+ +R+S LAL Q     + L   +P ++ E+V M T GD ILD  L+K+G K LF 
Sbjct: 8   NVVRVGSRRSNLALLQTGMAVNLLQKQNPHILFEVVEMATVGDKILDVSLSKIGDKSLFT 67

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS---NNYDSLDALP 120
           KELE ALL    D+ VHS+KDVP   P GL L  +  R  P D  +         L  LP
Sbjct: 68  KELENALLSGEVDLVVHSLKDVPSTLPSGLVLGCVFARVSPEDVVLMAPHYRGRKLSDLP 127

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--------------NGEYDA 166
            GS VGTS++RR   L  + P L   S+RGN+ TRL+KLD              +  YDA
Sbjct: 128 IGSTVGTSAVRRVATLTRKYPHLKFVSIRGNLNTRLAKLDTPPASKDNCCSGNPSPSYDA 187

Query: 167 IILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETAL 226
           IILA AG++R+G   RI   L  +    AV QGA+  ECRL D+   +LL+ ++    AL
Sbjct: 188 IILAKAGVERMGWSHRIDQVL-TDSF-YAVSQGALACECRLVDNFIMDLLSHIHDESAAL 245

Query: 227 RVTAERAMNTRLEGGCQVPIGSYA--ELIDG----EIWLRALVGAPDGSQIIRGERRGAP 280
              AER++  +L+GGC +PIG  +   L       ++ L A + + DG + I        
Sbjct: 246 TTIAERSLMRQLDGGCSIPIGVRSDLVLKGDLNYYQLTLHANILSVDGGKSIERSASVVF 305

Query: 281 QD 282
            D
Sbjct: 306 PD 307


>UniRef50_C5RMN3 Porphobilinogen deaminase n=1 Tax=Clostridium cellulovorans 743B
           RepID=C5RMN3_CLOCL
          Length = 300

 Score =  327 bits (838), Expect = 4e-88,   Method: Composition-based stats.
 Identities = 113/301 (37%), Positives = 168/301 (55%), Gaps = 8/301 (2%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +  ++RI TR+S LAL Q + V D +   HP +  E+V M T+GD ILD  L   GGKG 
Sbjct: 1   MKKIIRIGTRKSKLALMQTNIVIDAIKKKHPEINCEVVEMSTKGDEILDKSLLSFGGKGA 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS-NNYDSLDAL- 119
           FV E E A+     D+AVHS KD+P++   GL +V + +REDPRD  V+ NN D+++   
Sbjct: 61  FVSEFEKAIKSGEIDLAVHSAKDMPMDLLTGLKIVAVTKREDPRDVLVTANNKDTINDFN 120

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179
               ++GT+SLRR+ Q+     ++  + LRGNV  RL KL +GEYD IILA AGLKRLGL
Sbjct: 121 KTNKLIGTTSLRRKLQIKRLLNNVDTKDLRGNVQRRLEKLISGEYDGIILAAAGLKRLGL 180

Query: 180 ESRIR---AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236
               R     L  E  +PA GQG + +E R +      L  ++++ E    +  ER +  
Sbjct: 181 LDDERINLNYLSVEDFIPAGGQGIIAVEGRAE-EEFSFLKDSIHNEEAMYSLEVERYVMK 239

Query: 237 RLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
           +L  GC  PIG+Y+ +    I+L   +      ++ R +   + ++  ++   L EE+L 
Sbjct: 240 KLNAGCNEPIGAYSFIDKDTIFLD--IIYEHNGKVSRKKGSDSIENRLKLTEKLVEEILQ 297

Query: 297 N 297
            
Sbjct: 298 E 298


>UniRef50_O29026 Probable porphobilinogen deaminase n=1 Tax=Archaeoglobus fulgidus
           RepID=HEM3_ARCFU
          Length = 289

 Score =  327 bits (838), Expect = 4e-88,   Method: Composition-based stats.
 Identities = 111/294 (37%), Positives = 163/294 (55%), Gaps = 11/294 (3%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            L + TR S LAL Q + V ++L   +    VE+  + T GD++ D PL +  G G FV+
Sbjct: 2   KLIVGTRGSKLALAQTNKVAERLKERY---EVEIRIVKTAGDIMKDKPLYEFKGMGAFVR 58

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
            L+ AL E + D+AVHS KDVP +  +G  +  + ER+ P D  +S +  +L+ L  G++
Sbjct: 59  ALDTALAEGKVDVAVHSFKDVPSQRVEGTVVAAVIERDSPCDVLISRDGSTLEELDEGAV 118

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI- 183
           VGTSSLRR+ QL+  R DL   +LRGN+ TRL KL  G YDAI++A AGLKRLGL+  + 
Sbjct: 119 VGTSSLRRRAQLSRLRGDLRFENLRGNLDTRLRKLREGNYDAIVVAEAGLKRLGLDREVE 178

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
               PPE+ +P   QG + I  R  +    +L+A LN  +T L    ERA+   L  GC 
Sbjct: 179 YQPFPPEVIVPPANQGIIAIATRKGEE---DLVAFLNDEKTWLEAMVERAVIKELGVGCA 235

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           VP+G YAE     + L   +      + +R E + +   A +    + ++L   
Sbjct: 236 VPVGVYAE-AQSRVRLICEILD---KKYLRVEEKLSKDTAVEEAAEIGKDLRKE 285


>UniRef50_D1BFI8 Hydroxymethylbilane synthase n=4 Tax=Actinomycetales
           RepID=D1BFI8_SANKS
          Length = 312

 Score =  327 bits (838), Expect = 5e-88,   Method: Composition-based stats.
 Identities = 126/309 (40%), Positives = 173/309 (55%), Gaps = 14/309 (4%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LRI TR S LAL Q   V D L     G  VE+VP+ T GD +L   L+++GG G+FV  
Sbjct: 7   LRIGTRSSLLALTQTGTVADDLRRL-TGRPVEIVPVTTDGD-VLTGSLSQMGGTGVFVTA 64

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L  ALL++R D+AVHS+KD+P     GL  V    R+DPRDA  S     L  LP G+ V
Sbjct: 65  LRAALLDDRCDVAVHSLKDLPTAGVLGLQHV-TPVRQDPRDALCSRAGHRLADLPHGARV 123

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--DNGEYDAIILAVAGLKRLGLESRI 183
           GT S RR  QL   RPDL +  +RGN+ TRL ++  + G+ DA++LA AGL R+G E  I
Sbjct: 124 GTGSPRRAAQLRLVRPDLDVVDIRGNIDTRLGRVHPETGDLDAVVLAAAGLNRIGREHAI 183

Query: 184 RAALPPEISLPAVGQGAVGIECR----LDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
              +      PA GQGA+ +E R     +D         L+   T+L V AERA+  RLE
Sbjct: 184 TELISVTDMAPAPGQGALAVETRSSLLEEDPVVARAFDQLDDPATSLSVLAERALLARLE 243

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-----GAPQDAEQMGISLAEEL 294
            GC  P+G++A + DG + L A+V  PDGS+ +R  +       +  +A  +G ++A+  
Sbjct: 244 AGCAAPVGTHATVSDGLLTLHAVVARPDGSEQLRHNQSTEVADTSTAEAVALGEAVADHF 303

Query: 295 LNNGAREIL 303
           L  GA   +
Sbjct: 304 LALGAASFI 312


>UniRef50_C2FZW8 Porphobilinogen deaminase n=2 Tax=Sphingobacterium spiritivorum
           RepID=C2FZW8_9SPHI
          Length = 528

 Score =  326 bits (836), Expect = 6e-88,   Method: Composition-based stats.
 Identities = 112/311 (36%), Positives = 158/311 (50%), Gaps = 24/311 (7%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           ++  L I TR S LA+WQA+++KD+L A+  G+  EL  + T+GD+I    L K+ GKG 
Sbjct: 1   MNRKLIIGTRGSQLAMWQANHIKDRLAAA--GIDSELKVIKTQGDIIQHLRLDKLEGKGF 58

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY----DSLD 117
           F KELE  LL +  D+AVHS KD+P   P GL +  + ERE P +  +            
Sbjct: 59  FTKELEEELLSSTIDLAVHSHKDLPTVNPPGLIIAAVSERESPAELLIVLKDCVDIKKRL 118

Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKR- 176
           +L   + VGTSS RR+ QL   RPDL    LRGN+ TR+ KL +  YDAIILA AG++R 
Sbjct: 119 SLKHNATVGTSSNRRKAQLLSLRPDLEFDDLRGNLQTRIQKLRDENYDAIILAKAGVERI 178

Query: 177 -LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235
            + L       +PP   +PA  QG + I+ R  D    E L  +++ E A  +  ER + 
Sbjct: 179 DMDLSDFYVEEIPPVELIPAPAQGVLAIQIRESDQELFEALQVIHNKEVAEVIAVERKVL 238

Query: 236 TRLEGGCQVPIGSYAELIDGEIWLRALVGA-----PDGSQIIRGERRGAPQDAEQMGISL 290
              + GC  P+G Y    +G+      V       PD   I R    G           +
Sbjct: 239 NLFDAGCHAPLGCYCRKSEGKYEAWTSVAETSDEFPDRLYIQRDSTEG-----------M 287

Query: 291 AEELLNNGARE 301
           AEE+    A++
Sbjct: 288 AEEIFTKFAKD 298


>UniRef50_A4CHM3 Porphobilinogen deaminase n=4 Tax=Bacteroidetes RepID=A4CHM3_9FLAO
          Length = 315

 Score =  325 bits (835), Expect = 1e-87,   Method: Composition-based stats.
 Identities = 121/318 (38%), Positives = 167/318 (52%), Gaps = 18/318 (5%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   LRI TR S LALWQA  V+D+L A+  G   ELVP+ + GD++LD PL ++G  G+
Sbjct: 1   MSRALRIGTRDSELALWQAQTVRDRLEAA--GHRAELVPVKSTGDLVLDKPLYELGITGI 58

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F K L+VALL    D+AVHSMKDVP   P+G+    + ER   RD  V +        P 
Sbjct: 59  FTKTLDVALLREDIDLAVHSMKDVPTALPEGICQAAVLERASARDVLV-HKGLGFLDGP- 116

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
              + T SLRR+ Q   R P   +  LRGNV TRL  L    +D  I A AGL+R+GL  
Sbjct: 117 -GTIATGSLRRKAQWLNRYPAHQVTGLRGNVNTRLKLLRENSWDGAIFAQAGLERIGLLP 175

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
                L  +  LPA  QGA+ +  R  D+  RE    L+H ++AL V  ER     LEGG
Sbjct: 176 DNAEPL--DWMLPAPAQGAMLVVARTSDTAAREAARPLHHEQSALEVAVEREFLRTLEGG 233

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER-RGAPQ----------DAEQMGISL 290
           C  PIG+     DG++ L   + + DG +  R  R  G+ +          DA + G + 
Sbjct: 234 CSAPIGARVHAADGQLHLEGGLFSLDGKKAFRVTRHTGSLEAGGTGDARFQDAGEFGAAC 293

Query: 291 AEELLNNGAREILAEVYN 308
           A E+L++G   ++  +  
Sbjct: 294 AREILDSGGAVLMESIRK 311


>UniRef50_B3RTQ8 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens
           RepID=B3RTQ8_TRIAD
          Length = 314

 Score =  325 bits (834), Expect = 1e-87,   Method: Composition-based stats.
 Identities = 120/338 (35%), Positives = 172/338 (50%), Gaps = 64/338 (18%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M + V+RI TR+S LA+ Q H V D L   HP   +E+V M T GD +LD  L ++G   
Sbjct: 4   MEETVVRIGTRKSQLAMIQTHSVVDALREIHPKARIEIVTMDTIGDRVLDKALPEIGQTN 63

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LF K+LEVAL +N+ D+ +HS+KDVP   P+GL +  I                      
Sbjct: 64  LFTKDLEVALTDNKIDLIIHSLKDVPSTLPEGLAIAAI---------------------- 101

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGL 179
            G+++GTSSLRR  QL  R P L   ++RGN+ TRL KLD  G YDA++LA AG++    
Sbjct: 102 -GNVIGTSSLRRIAQLKRRFPHLKFENVRGNLNTRLKKLDESGIYDALVLAGAGVE---- 156

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
                  L P+  L A+GQGA+GIE R +D +T  L++A    ++ +   AERA    L+
Sbjct: 157 -------LTPDECLYAIGQGALGIEIRKNDKKTFSLISAYTDFDSLVCNAAERAFLRFLD 209

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ------------------ 281
            GC VPIG Y E  + ++ +   V + DGS+ ++                          
Sbjct: 210 KGCSVPIGVYTEFTENKLKITGAVFSLDGSKRVQYSDECTISGLNAKDDCESNYESLSSI 269

Query: 282 -----------DAEQMGISLAEELLNNGAREILAEVYN 308
                      +AE++G  +AE +L N   E+LAE   
Sbjct: 270 LCPSEMCNSLIEAERLGKYVAEMILKNHGGEVLAEARQ 307


>UniRef50_Q47LA7 Porphobilinogen deaminase n=3 Tax=Actinomycetales RepID=HEM3_THEFY
          Length = 320

 Score =  324 bits (832), Expect = 2e-87,   Method: Composition-based stats.
 Identities = 127/319 (39%), Positives = 177/319 (55%), Gaps = 11/319 (3%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M     R+ TR+S +A  Q+  V + L A   G+ VELV + + GD I    L ++GG G
Sbjct: 1   MSTTPARLGTRRSTMATNQSRRVAEILTAR-TGVPVELVLITSFGD-ITRAHLTQLGGTG 58

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           +FV  L  ALL    + AVHS+KD+P    +G+ L  + ER+DPRDA  + +      LP
Sbjct: 59  VFVSALRDALLAGEVEFAVHSLKDLPTAPTEGIVLAAVTERDDPRDALCARDGLKFADLP 118

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
            G+ VGT S RR  QLA  RPDL    +RGN  TRL K+ +GE DA++LA AGL R+G  
Sbjct: 119 PGATVGTGSPRRVAQLAALRPDLRYVPIRGNAETRLGKVASGELDAVVLAYAGLHRVGRL 178

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDD-SRTRELLAALNHHETALRVTAERAMNTRLE 239
             +      +  LPA GQGA+ +ECR  D +     L A++H  T   VTAER +   LE
Sbjct: 179 DDVTDVFDVDQVLPAPGQGALAVECRTADFTGPLRYLTAVDHLPTRAAVTAERVILAELE 238

Query: 240 GGCQVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQD-------AEQMGISLA 291
            GC  P+G+YAE + +  + LRA V A DGSQ +R E+     +       A  +G  LA
Sbjct: 239 AGCAAPVGAYAEFVAEDRLRLRAAVVATDGSQAVRAEQTVTVTEFPDAVQAATALGRQLA 298

Query: 292 EELLNNGAREILAEVYNGD 310
            +++  GA +I+A+   G 
Sbjct: 299 HDMIEQGADQIVADAAAGR 317


>UniRef50_C9M5W1 Hydroxymethylbilane synthase n=1 Tax=Jonquetella anthropi E3_33 E1
           RepID=C9M5W1_9BACT
          Length = 714

 Score =  324 bits (832), Expect = 2e-87,   Method: Composition-based stats.
 Identities = 115/295 (38%), Positives = 160/295 (54%), Gaps = 7/295 (2%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             LR+A+R+S LA+ Q+  V ++L  +  G  VE++P  TRGD + D  L   GGKGLFV
Sbjct: 424 RPLRLASRESELAMAQSRLVAERLHEA-TGFDVEIIPFRTRGDAVADRRLESAGGKGLFV 482

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KELE A+L  +AD+AVHS+KD+P   P GL    + +R+   D  V     +   +    
Sbjct: 483 KELERAILSGQADLAVHSLKDMPSSCPDGLAFAALMDRQTAFDCLVLRPGLTGRPV---- 538

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            +GTSS RR  Q      D     LRGN+ TRLSKLD GE+DA+ILA AGL+RLGL+ R+
Sbjct: 539 RIGTSSARRIAQGRALFSDAQFVPLRGNLRTRLSKLDGGEFDALILAEAGLRRLGLQERV 598

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
                 +  +P+ GQG + ++C  D     +L++ L+         AERA   RL GGC 
Sbjct: 599 SRVFSADQMIPSAGQGTLAVQCPFDGP-VFDLVSQLDEPAVRTCCLAERAFIDRLNGGCT 657

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNG 298
            P G+YA +    I +  L   PDG   + G+  G   D   +   LA+ L   G
Sbjct: 658 APHGAYARVDGETIEMIGLYVRPDGKT-LSGKISGPAADGPSLAAELADRLKRRG 711


>UniRef50_Q4T5L1 Chromosome undetermined SCAF9206, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4T5L1_TETNG
          Length = 385

 Score =  324 bits (831), Expect = 3e-87,   Method: Composition-based stats.
 Identities = 134/383 (34%), Positives = 191/383 (49%), Gaps = 85/383 (22%)

Query: 13  SPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLE 72
           S LA  Q   V +KL   +P + +E+V M T GD ILDT L+K+G K LF KELE AL  
Sbjct: 1   SQLARIQTDSVAEKLKELYPDVHLEIVAMSTTGDKILDTALSKIGEKSLFTKELENALER 60

Query: 73  NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALPAGSIVGTSS 129
           N  D+ VHS+KD+P   P G  +  + +RE+P DA V +      +LDALPA S++GTSS
Sbjct: 61  NEVDLVVHSLKDLPTSLPPGFTIGAVLKRENPHDAVVLHPKNAGKTLDALPAHSVIGTSS 120

Query: 130 LRRQCQLAERRPDLIIRSL------------------------RGNVGTRLSKLDN-GEY 164
           LRR  QL +R P L  + +                        RGN+ TRL KLD   ++
Sbjct: 121 LRRAAQLKKRFPHLDFKDIVSSERCFLPVQPGHRCFFLSSRSQRGNLNTRLKKLDEKEDF 180

Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224
            AIILA AGL+R+G ++RI   L PE  + AVGQGA+ +E R  D+   E+++ L+  +T
Sbjct: 181 AAIILAAAGLRRMGWDNRISQILEPEDCMYAVGQGALAVEVRAKDADILEMVSVLHDPDT 240

Query: 225 ALRVTAERAMNTRL----------------------------EGGCQVPIGSYAELIDGE 256
            LR  AERA    L                            EGGC VP+  + ++ D +
Sbjct: 241 VLRCIAERAFLKHLVQHTHTHTHTHTHTRSLAVAHWNLFCLQEGGCSVPVAVHTKVKDSQ 300

Query: 257 IWLRALVGAPDGSQIIRGERR--------GAPQD---------------------AEQMG 287
           ++L   V + DGS  ++   +        G+P +                     AE++G
Sbjct: 301 LYLTGAVYSLDGSDSLKETMQTSVAAPADGSPDEVDECARVGVTANKIPGEAQDRAERLG 360

Query: 288 ISLAEELLNNGAREILAEVYNGD 310
           + LA+ LL+ GA+EIL      +
Sbjct: 361 VDLAKLLLSKGAKEILTVARQLN 383


>UniRef50_A8AAB4 Probable porphobilinogen deaminase n=1 Tax=Ignicoccus hospitalis
           KIN4/I RepID=HEM3_IGNH4
          Length = 304

 Score =  324 bits (831), Expect = 3e-87,   Method: Composition-based stats.
 Identities = 113/295 (38%), Positives = 158/295 (53%), Gaps = 7/295 (2%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILD--TPLAKVGGKGLF 62
            ++IA R S L+L Q       L+   P L  E++ + T GD        LAK G  GLF
Sbjct: 2   KIKIAARGSKLSLKQVSMFTSYLLKFFPDLEYEVITVKTTGDKANAPFEELAKRGLTGLF 61

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-DSLDALPA 121
            KE+  A+LE +AD+AVHS+KD+P E    L +     R+ P D  +S      +  LP 
Sbjct: 62  EKEVNKAVLEGKADVAVHSLKDLPTELDPRLEIAAFLPRDPPYDVLISRAGNYDIFDLPK 121

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           GS+VGTSS RR+  +   RPDL+++ LRGNV TRL KL  GEYDAI+LA AG+ RLGL +
Sbjct: 122 GSVVGTSSARRKALIKNLRPDLVVKDLRGNVDTRLEKLRRGEYDAIVLAEAGVSRLGL-N 180

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
                L   +  P+ GQG +    R   S   +LL +++  ++    TAER +     GG
Sbjct: 181 VDYVRLDWRLFPPSPGQGIIVAVTRKG-SEISDLLKSISDVKSEKLATAERTVLKEFGGG 239

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
           C V +G+ A      I LRA V +P G + +  E  G  +  E++G+  AE L  
Sbjct: 240 CFVALGAIAFEEGSLIRLRATVLSPSGRERVDVELIG--KGPEEVGMRAAERLKA 292


>UniRef50_D2RH82 Porphobilinogen deaminase n=2 Tax=Archaeoglobaceae
           RepID=D2RH82_ARCPR
          Length = 292

 Score =  323 bits (830), Expect = 4e-87,   Method: Composition-based stats.
 Identities = 107/296 (36%), Positives = 161/296 (54%), Gaps = 9/296 (3%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   + + TR S LAL Q   V ++L     G  VE+  + + GD++ D PL +  G G 
Sbjct: 1   MSERVVVGTRGSKLALAQTSKVVERLKEE--GYSVEIRIIKSTGDIMKDKPLYEFKGSGA 58

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FV+ LE AL+    D+AVHS KD+P    +G+ +  + ER+ P DAF++ N +SL+ +  
Sbjct: 59  FVRALEHALVRGEIDVAVHSYKDIPSNMLEGVTVSAVLERDSPYDAFIARNGESLEEIKP 118

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
            +++GTSSLRR+ QL   R DL   +LRGNV TRL KL  G YDAI+LA AG++RLGL  
Sbjct: 119 NAVIGTSSLRRRAQLKLYRSDLRFENLRGNVDTRLRKLREGLYDAIVLAEAGIQRLGLNV 178

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
           +    LP E  +P   QG + ++ R+ +    +L+  +NH ET +    ER +   L  G
Sbjct: 179 KY-QRLPIERFVPPANQGIIAVQTRVGEE---DLVKFMNHEETWIEAEVERIVMKTLGVG 234

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           C +P G YAE    ++ L   V   DG +  +     + + A +    +AE     
Sbjct: 235 CAIPAGIYAECRG-KVRLIVQVIR-DGRE-FKVIEELSRESAIEEAREIAENFREE 287


>UniRef50_C6XST0 Porphobilinogen deaminase n=2 Tax=Pedobacter RepID=C6XST0_PEDHD
          Length = 526

 Score =  323 bits (830), Expect = 4e-87,   Method: Composition-based stats.
 Identities = 115/270 (42%), Positives = 157/270 (58%), Gaps = 8/270 (2%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             L I TR S LALWQA+++KDKL A   G+  EL  + T+GD IL+  L K+ GKG F 
Sbjct: 2   KRLIIGTRGSDLALWQANFIKDKLAAI--GVEAELKIIKTQGDKILNLRLDKLEGKGFFT 59

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRD-AFVSNNYDSLD---AL 119
           KELE  LL    DIAVHS KD+P   P GL +  + EREDP +   +  +  S++   +L
Sbjct: 60  KELEEELLGGTIDIAVHSHKDLPTVHPAGLTIAAVTEREDPSELLLILKDCVSINHKLSL 119

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG- 178
             G++VGTSS RR+ QL   RPDL I  LRGNV TR+ KL + +YDAI+LA AG+ RL  
Sbjct: 120 KKGAMVGTSSNRRKAQLLALRPDLNIEDLRGNVPTRIQKLRDEDYDAILLARAGVNRLNI 179

Query: 179 -LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237
            L       +     +PA  QGA+ I+ R +++   ++L  +NH ETA  +  ER +   
Sbjct: 180 DLSEFHVEVVDTTELVPAPAQGALAIQIRENENELFDILQQINHSETAEEIAIERKVLNL 239

Query: 238 LEGGCQVPIGSYAELIDGEIWLRALVGAPD 267
            EGGC +P+G Y +  DG+  +       D
Sbjct: 240 FEGGCHMPLGCYCKKEDGQYEVWTSKAETD 269


>UniRef50_A3MLK5 Porphobilinogen deaminase n=155 Tax=Proteobacteria RepID=HEM3_BURM7
          Length = 329

 Score =  323 bits (828), Expect = 6e-87,   Method: Composition-based stats.
 Identities = 162/315 (51%), Positives = 208/315 (66%), Gaps = 3/315 (0%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           L   L IA+R+S LA+WQA +V+D L   +P   V+++ M TRGD ILD  L+KVGGKGL
Sbjct: 10  LPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGL 69

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FVKELE AL + RAD+AVHS+KDVP+  P+G  L  +  REDPRDAFVSN+Y SLDALPA
Sbjct: 70  FVKELESALADGRADLAVHSLKDVPMALPEGFALAAVMSREDPRDAFVSNDYASLDALPA 129

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G++VGTSSLRR+  L  R P L +R LRGN+ TRL+KLD G+Y AIILA AGLKRLGL +
Sbjct: 130 GAVVGTSSLRREAMLRARHPRLDVRPLRGNLDTRLAKLDRGDYAAIILAAAGLKRLGLAA 189

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
           RIRA L  + SLPA GQGA+GIE     +     LA L+ H +AL V AERA++  L G 
Sbjct: 190 RIRALLDVDDSLPAAGQGALGIEIAARRADVAAWLAPLHDHASALAVEAERAVSRALGGS 249

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQI---IRGERRGAPQDAEQMGISLAEELLNNG 298
           C+VP+ ++A    GE+ L   V   DG+++       R     DA  +G  +++ L   G
Sbjct: 250 CEVPLAAHAVWRGGELHLTGSVSTTDGARVLAAHAHARAATAADALALGRRVSDALERQG 309

Query: 299 AREILAEVYNGDAPA 313
           AR I+  +    A A
Sbjct: 310 ARAIVDALVAASAQA 324


>UniRef50_D2NS36 Porphobilinogen deaminase n=2 Tax=Micrococcaceae RepID=D2NS36_9MICC
          Length = 454

 Score =  322 bits (826), Expect = 1e-86,   Method: Composition-based stats.
 Identities = 134/372 (36%), Positives = 186/372 (50%), Gaps = 71/372 (19%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPG------------LVVELVPMVTRGDVI 48
           M  +   + TR S LAL Q+    + + + +              +   L  + T GD +
Sbjct: 78  MSHHEYILGTRGSALALTQSRIAAETVTSLYTEHQAHHGAADAEVVDFTLRTVKTEGD-V 136

Query: 49  LDTPLAKVGGKGLFVKELEVALLENR-------ADIAVHSMKDVPVEFPQGLGLVTICER 101
           L  PLA +GG G+F   L   LL+          D+AVHS+KD+P     GL +    +R
Sbjct: 137 LTGPLATLGGTGVFAAALRQRLLDGENASEENRVDMAVHSLKDLPSAPCPGLVIAATLKR 196

Query: 102 EDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-- 159
           EDPRDA V+ +  +LD LP GS VGT S RR  QL   RPDL I  +RGNVGTR+ ++  
Sbjct: 197 EDPRDALVARDGLTLDTLPEGSRVGTGSPRRAAQLRALRPDLEIVDIRGNVGTRIGRVKG 256

Query: 160 ----------------------------DNGEYDAIILAVAGLKRLGLESRIRAALPPEI 191
                                        +G+ DA++LAV+GLKRLG E  I   L P  
Sbjct: 257 LEEHAGKQVVLRQNTETSERADHGVGTERSGDCDAVVLAVSGLKRLGKEELITEYLDPTR 316

Query: 192 SLPAVGQGAVGIECRLD-----------DSRTRELLAAL-------NHHETALRVTAERA 233
            LPA GQGA+ +E R             D      + AL       NHHET L V+AERA
Sbjct: 317 MLPAPGQGALALEVRESEFENPDPAVLADPEVARPVRALGRALLAANHHETRLAVSAERA 376

Query: 234 MNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---AEQMGISL 290
           +  RLE GC  PIG+YA +++G++ L  +V +PDG+ ++R     A  D   AE++G+ +
Sbjct: 377 LLRRLEAGCAAPIGAYAHVVEGDLVLSVVVASPDGTDMLRHTSATAELDVPGAERLGVRV 436

Query: 291 AEELLNNGAREI 302
           AE+LL  GA  +
Sbjct: 437 AEDLLQMGAAAL 448


>UniRef50_C1TM53 Porphobilinogen deaminase n=1 Tax=Dethiosulfovibrio peptidovorans
           DSM 11002 RepID=C1TM53_9BACT
          Length = 454

 Score =  322 bits (826), Expect = 1e-86,   Method: Composition-based stats.
 Identities = 124/289 (42%), Positives = 159/289 (55%), Gaps = 8/289 (2%)

Query: 10  TRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVA 69
           +R+S LA  Q       L     GL VE+  M T GD   D  L+  GG G FVK LE A
Sbjct: 160 SRKSALARAQTMEAARALAKK--GLPVEIKTMSTCGDEKQDCHLSAFGGNGAFVKCLEEA 217

Query: 70  LLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSS 129
           ++E + D A+HS+KDVP   P GL LV +  R    D  VSN+   L+ LPAG++VGTSS
Sbjct: 218 IMEGKGDGAIHSLKDVPSVLPDGLELVAVLPRASTSDVIVSNHKGGLEGLPAGAVVGTSS 277

Query: 130 LRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPP 189
           LRR+ QLA  RPDL    +RGNV TRL+KL +G+ DAI+LA AGL RLG+       LP 
Sbjct: 278 LRRKAQLAITRPDLDYTLIRGNVNTRLAKLQSGDADAIVLAKAGLDRLGISPEGATTLP- 336

Query: 190 EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSY 249
              LPA  QG + +E R   SR  E   A+NH  T L   AER +   L+ GC VP  + 
Sbjct: 337 --FLPAPCQGIIAVEARSG-SRLAEEFRAINHRPTWLMALAERELLESLQVGCHVPFAAL 393

Query: 250 AELIDGEIWLRALVGAPDGSQI-IRGERRG-APQDAEQMGISLAEELLN 296
           +E + GE+ LRA   + DG  I   G     +  DA  +G  +A  +  
Sbjct: 394 SEWVGGELRLRAQTLSYDGRHIDFEGSLAVRSDDDARDLGRDVALSIKA 442


>UniRef50_UPI000174444E Hydroxymethylbilane synthase n=1 Tax=Verrucomicrobium spinosum DSM
           4136 RepID=UPI000174444E
          Length = 318

 Score =  322 bits (826), Expect = 1e-86,   Method: Composition-based stats.
 Identities = 119/307 (38%), Positives = 156/307 (50%), Gaps = 18/307 (5%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG----- 57
            + LR+ TR S LAL QA  V+  L A+HP L VE   + T GD   D   ++       
Sbjct: 6   TDTLRLGTRGSELALRQAEMVEAALHAAHPYLRVERKVIATTGDKRPDLRFSEFTEGDRL 65

Query: 58  GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD 117
            KG+F KELE+AL     DIAVHS+KDVP    +   +  +  R    D  +S    +L 
Sbjct: 66  DKGIFTKELEIALASGEIDIAVHSLKDVPTVLDEKFFIAGVLPRAPIEDVLISREGYTLA 125

Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG-EYDAIILAVAGLKR 176
            LPAG+ VGTSS+RR  QL    P +    +RGNV TR+ KL    + DAI+LA AGL+R
Sbjct: 126 TLPAGAKVGTSSVRRIRQLQWLNPGVECVEIRGNVPTRIRKLFAPSDLDAILLARAGLER 185

Query: 177 LGLES----------RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETAL 226
           L L                 L  E  LPA GQGA+GIE R+DD+ T E L A+NH ET  
Sbjct: 186 LSLLDGEHVVVDGQPLHAVILDCEEFLPAAGQGAIGIEARVDDAHTLEFLKAINHEETYA 245

Query: 227 RVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPD--GSQIIRGERRGAPQDAE 284
           RVTAER     L+ GCQ PIG++  L +G + ++  V      G               +
Sbjct: 246 RVTAEREFLHILKAGCQTPIGAHTFLENGVLQMKVRVFDETDPGRPPKEVTSTEPYHSPK 305

Query: 285 QMGISLA 291
            +   +A
Sbjct: 306 GLAAEVA 312


>UniRef50_C2GGB5 Porphobilinogen deaminase n=2 Tax=Corynebacterium glucuronolyticum
           RepID=C2GGB5_9CORY
          Length = 290

 Score =  322 bits (826), Expect = 1e-86,   Method: Composition-based stats.
 Identities = 121/299 (40%), Positives = 165/299 (55%), Gaps = 11/299 (3%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            LRI TR S LA  QA +V+D L+ +  G   EL  + T GD  L +P+ K+G  G+F +
Sbjct: 2   TLRIGTRGSKLATTQAGHVRDALIRA--GYDAELTIITTPGDKNL-SPVQKIG-VGVFTQ 57

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
            L  A+  +  DIAVHS KD+P   P+GL  +    RE P +A ++ +  +LD LP G+ 
Sbjct: 58  ALREAMDRDEIDIAVHSCKDLPTGQPEGLATI-YPVRETPCEALIARDGLTLDQLPEGAK 116

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGT + RR  QL   RPDL IR LRGNV TR+ K+ +GE DA+ILA AGL R+G      
Sbjct: 117 VGTGAPRRISQLKALRPDLDIRPLRGNVDTRMGKVTSGELDAVILAHAGLTRIGRGDEAT 176

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
               P   +PA  QG + +E R        L   ++ H T L   AERA+ + L+ GC  
Sbjct: 177 QVFDPTYLMPAPAQGILAVESRTHVDAISTL---IDDHAT-LSAQAERAVLSTLQAGCTA 232

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           P+ +Y+ +   EI L A   A DGS+ I     G   D   +G S+AE+L   GA EI+
Sbjct: 233 PLAAYSTVSGDEITLTAGAFALDGSKQIVETATGT--DPVALGTSVAEKLRACGAEEII 289


>UniRef50_D1VCA1 Porphobilinogen deaminase n=1 Tax=Frankia sp. EuI1c
           RepID=D1VCA1_9ACTO
          Length = 380

 Score =  321 bits (824), Expect = 2e-86,   Method: Composition-based stats.
 Identities = 124/344 (36%), Positives = 179/344 (52%), Gaps = 44/344 (12%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           L + LR+ TR+S LAL Q+  V D+L     G+ V+LV +VT GD      ++++G  G+
Sbjct: 36  LPSRLRLGTRRSALALAQSGMVADELRTR-LGIEVDLVHVVTEGDRNR-AEISQLGSTGV 93

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           +V  L  ALL    D+AVHS+KD+P   P+G+ L  I  RED RD  VS    +L  L  
Sbjct: 94  WVSALREALLSGEVDLAVHSLKDLPTAPPEGITLAAIPPREDVRDVLVSPTGRTLAQLGP 153

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ +GT + RR  QL      L +  +RGNV TR+ K  +GE DA++LA AGL RL    
Sbjct: 154 GARIGTGAPRRAAQLRALGLGLDVVPIRGNVDTRIKKAIDGEVDAVVLARAGLARLDRLD 213

Query: 182 RIRAALPPEISLPAVGQGAVGIECRL--------------DDSR---------------- 211
            I   L PE+ LPA GQGA+ IEC                +D                  
Sbjct: 214 AITELLEPEVMLPAPGQGALAIECVATTLAPLTLLTVGTPEDQGAVTGMSCPVAPGSGVE 273

Query: 212 --TRELLAA-LNHHETALRVTAERAMNTRLEGGCQVPIGSYAEL---------IDGEIWL 259
                LL   L+   +++ V AERA    +E GC  P+G+ A++          +GE+ L
Sbjct: 274 IPLERLLRFVLDDAPSSVAVRAERAFLAAIEAGCTAPVGALAQVLPARGQAPASEGEVRL 333

Query: 260 RALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           RA+V + DG+ ++R E  G+  D E +G  LA++LL+ GA  ++
Sbjct: 334 RAVVASLDGTTVLRRELGGSTADPEALGRRLADDLLSAGAHTLM 377


>UniRef50_A4WN24 Probable porphobilinogen deaminase n=3 Tax=Thermoproteaceae
           RepID=HEM3_PYRAR
          Length = 297

 Score =  321 bits (824), Expect = 2e-86,   Method: Composition-based stats.
 Identities = 110/293 (37%), Positives = 157/293 (53%), Gaps = 6/293 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L +ATR S L++ Q   +  ++ A  P +  E+  + T GD + D PL ++G KG+F KE
Sbjct: 3   LVVATRGSKLSMLQTEELLAQIKAVEPSIEFEIKIVKTTGDEVQDKPLYQIGVKGIFEKE 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           + +A+L   AD+AVHS+KD+P E   GL L    +R  P DA VS     L+ LP G++V
Sbjct: 63  VNLAVLRGEADVAVHSLKDLPSELSPGLVLAGFSKRAPPFDAVVSTAGYVLETLPRGALV 122

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL-GLESRIR 184
           GTSS+RR   +   RPD+ +  LRGNV TR++K+  G+YDA I+AVAG+ RL G    I+
Sbjct: 123 GTSSVRRAEFVKAIRPDVRVEPLRGNVDTRINKILQGKYDAAIMAVAGIYRLYGASPPIK 182

Query: 185 -AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
            A L PE+  P  GQG V    R  DS   +LL   +  + +L   AER     +  GC 
Sbjct: 183 LAVLRPEVLPPPPGQGIVAAVVREADSWLIDLLKKASDPKASLEAIAEREFLKAVGAGCH 242

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
           V IG  A   +  +   A   +  G +       G   D  ++G   AEE+  
Sbjct: 243 VAIGGVAFARNDTVEFIAGYAS--GGRKYIVRVVG--DDPVEVGRRAAEEIRK 291


>UniRef50_Q2NEP4 HemC n=4 Tax=Methanobacteriaceae RepID=Q2NEP4_METST
          Length = 290

 Score =  320 bits (822), Expect = 3e-86,   Method: Composition-based stats.
 Identities = 91/292 (31%), Positives = 149/292 (51%), Gaps = 4/292 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           + + TR S LA  Q   V   L     G  +E   + T GD I ++ L  +  KG+F KE
Sbjct: 1   MIVGTRGSKLATTQTKTVVKALEEIT-GEEIETKIIKTTGDKIKNSQLYNIDAKGIFTKE 59

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L+ AL++   D AVHS KD+P E    L +  I +RE   +  +SN   S D LP  + +
Sbjct: 60  LDTALIDGSIDFAVHSFKDLPSELNDQLTITAIPQREAINEVLISN--YSWDELPENATL 117

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS+RR+         +  + +RGN+ TR+ K++ GEYDA I+A+AG+ RLGL+  I+ 
Sbjct: 118 GTSSVRREAFCKLHGKKIQTKPIRGNIDTRIRKVEEGEYDATIMALAGINRLGLQEHIKE 177

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
               +   P  GQGA+ +     DS   ++++ LNH ++ +    E+A+   +  GCQ P
Sbjct: 178 VFDEQYITPPAGQGALAVMTHK-DSEYNDVISKLNHEDSRIEAMTEKAILETIGVGCQWP 236

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           IG  +++    I +   + +P+G  +    +     +A      +  +L  +
Sbjct: 237 IGIVSKVDGNNINIHCKLLSPEGKLLADVNKTTDKNNAINTAKVIGTKLRED 288


>UniRef50_Q9F7M2 Predicted porphobilinogen deaminase n=2 Tax=Bacteria
           RepID=Q9F7M2_PRB01
          Length = 303

 Score =  320 bits (821), Expect = 4e-86,   Method: Composition-based stats.
 Identities = 111/306 (36%), Positives = 173/306 (56%), Gaps = 4/306 (1%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            +RIATRQS LA++QA +V D+L+A    + VELVPM + GD   D PL ++GGKGLF+ 
Sbjct: 2   KIRIATRQSELAMYQAKFVADELLAKINNIKVELVPMTSEGDQ-TDKPLHEIGGKGLFIS 60

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
            LE +L  + ADIAVHS+KDVP +      ++++  RE P D  +S +  S       S 
Sbjct: 61  TLESSLEADEADIAVHSLKDVPAKLDPKFKIISVFSRESPEDLLLSKDGKSFSEFARNST 120

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GTS  RR+ Q+   RPD+    +RGN+ TR+ KL++G +D +++A A +KRLGL+    
Sbjct: 121 IGTSGPRRKAQINNLRPDIKTIPVRGNIATRIKKLNDGLFDGLVVAKAAIKRLGLKQNSY 180

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
                E  LP+  QG + IEC  D     ELL  +   +  +  +AER+    +EG C  
Sbjct: 181 E-FSIEEMLPSASQGYIAIECLSDKKDIIELLENIGDPKELILASAERSFVAAMEGTCLS 239

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304
           PI    E  +G+I +   + + +G++ I  E+  + QD     +  A+E +  GA+ ++ 
Sbjct: 240 PIAILCEDKNGQIKISGKILSYEGNEKIYKEKISSFQDIAIDIMLFADEFILEGAKSLI- 298

Query: 305 EVYNGD 310
            + N +
Sbjct: 299 -LKNDN 303


>UniRef50_C6R3Y0 Hydroxymethylbilane synthase n=1 Tax=Rothia mucilaginosa ATCC 25296
           RepID=C6R3Y0_9MICC
          Length = 377

 Score =  319 bits (819), Expect = 7e-86,   Method: Composition-based stats.
 Identities = 134/372 (36%), Positives = 186/372 (50%), Gaps = 71/372 (19%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLV------------VELVPMVTRGDVI 48
           M  +   + TR S LAL Q+    + + + +                 EL  + T GD +
Sbjct: 1   MSHHEYTLGTRGSALALTQSRIAAETVTSLYTEHQAHHGAENPEAVSFELRTVKTEGD-V 59

Query: 49  LDTPLAKVGGKGLFVKELEVALLENR-------ADIAVHSMKDVPVEFPQGLGLVTICER 101
           L  PLA +GG G+F   L   LL+          D+AVHS+KD+P     GL +    +R
Sbjct: 60  LTGPLATLGGTGVFAAALRQRLLDGENASEENRVDMAVHSLKDLPSAPCPGLVVAATLKR 119

Query: 102 EDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL-- 159
           EDPRDA V+ +  ++D LP GS VGT S RR  QL   RPDL I  +RGNVGTR+ ++  
Sbjct: 120 EDPRDALVARDGLTVDTLPEGSRVGTGSPRRAAQLRALRPDLEIVDVRGNVGTRIGRVKG 179

Query: 160 ----------------------------DNGEYDAIILAVAGLKRLGLESRIRAALPPEI 191
                                        +G+ DA++LAV+GLKRLG E  I   L P  
Sbjct: 180 LEEHAGKQVVLRQNAETSERADHGVGTERSGDCDAVVLAVSGLKRLGKEELITEYLDPTR 239

Query: 192 SLPAVGQGAVGIECRLD-----------DSRTRELLAAL-------NHHETALRVTAERA 233
            LPA GQGA+ +E R             D      + AL       NHHET L V+AERA
Sbjct: 240 MLPAPGQGALALEVRESEFENPDSAVLADPEVARPVRALGRALLAANHHETRLAVSAERA 299

Query: 234 MNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---AEQMGISL 290
           +  RLE GC  PIG+YA +++G++ L  +V +PDG+ ++R     A  D   AE++G+ +
Sbjct: 300 LLRRLEAGCAAPIGAYAHVVEGDLVLNVVVASPDGTDMLRHTSATAELDVPGAERLGVRV 359

Query: 291 AEELLNNGAREI 302
           AE+LL  GA  +
Sbjct: 360 AEDLLQMGAAAL 371


>UniRef50_A0QLI0 Porphobilinogen deaminase n=69 Tax=Actinomycetales RepID=HEM3_MYCA1
          Length = 315

 Score =  318 bits (816), Expect = 2e-85,   Method: Composition-based stats.
 Identities = 133/311 (42%), Positives = 175/311 (56%), Gaps = 13/311 (4%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR S LA  QA  V+D L+A   G   ELV + T GD     P+  +G  G+F   
Sbjct: 2   IRIGTRGSLLATTQAGGVRDALIAR--GHPAELVTITTAGDR-SSGPIESLG-VGVFTTA 57

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L  A+ E R D AVHS KD+P        +  I  R DPRDA V+ +   L  LP GS+V
Sbjct: 58  LREAIEEGRVDAAVHSHKDLPTADDPRFAVAAIPARNDPRDAVVARDGLVLGELPPGSLV 117

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS RR  QL      L IR LRGN+ TRL+++ +G+ DAI++A AGL RLG    +  
Sbjct: 118 GTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLGDVTE 177

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L P   LPA  QGA+ +ECR  DSR   +LA L+  +T   VTAERA+   LE GC  P
Sbjct: 178 TLEPVQMLPAPAQGALAVECRAGDSRLAAVLAELDDADTRASVTAERALLAELEAGCSAP 237

Query: 246 IGSYAELID---------GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
           +G+ AE+++          E+ LR  V A DGS +IR    G P  A ++G+S+A EL  
Sbjct: 238 VGAIAEVVESIDEDGRIFEELSLRGCVAALDGSDVIRASGIGTPGRARELGLSVAAELFE 297

Query: 297 NGAREILAEVY 307
            GARE+++   
Sbjct: 298 LGARELMSGAR 308


>UniRef50_Q8D2W2 HemC protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of
           Glossina brevipalpis RepID=Q8D2W2_WIGBR
          Length = 291

 Score =  318 bits (816), Expect = 2e-85,   Method: Composition-based stats.
 Identities = 132/289 (45%), Positives = 193/289 (66%), Gaps = 1/289 (0%)

Query: 20  AHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAV 79
           +   K KL+  HP L ++LVP++T GD+I          KGLF+KELE +LL+ ++DIAV
Sbjct: 3   SKLCKKKLLHYHPKLNIKLVPILTTGDLINKIRNNITNEKGLFIKELEKSLLKYQSDIAV 62

Query: 80  HSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAER 139
           HSMKD    F   LGL  IC+R+DPRDA VSN Y+++ +LP  + VGTSSLRR+CQL   
Sbjct: 63  HSMKDFSSSFLDSLGLAAICKRDDPRDAIVSNYYNNIISLPNNAKVGTSSLRRKCQLLSI 122

Query: 140 RPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQG 199
           RPDL I   +GN+ +RL KL+ G +DA+ILA A LKRL +  ++   + P   LPA+GQG
Sbjct: 123 RPDLKIFPCKGNIHSRLKKLNQGVFDALILATAALKRLKINEQMYTPIDPSYLLPAMGQG 182

Query: 200 AVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID-GEIW 258
           ++ I+CRL D++  +++  +N+ +TAL + +E+ + + L  GC+VPIGSYA++ +   IW
Sbjct: 183 SIAIQCRLYDNKIIDIVRNINNKKTALCINSEKIVVSMLGTGCRVPIGSYAKIENKNTIW 242

Query: 259 LRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVY 307
           +RALVG+ DGS IIR E +    +AE++     + L+N GA+ IL +  
Sbjct: 243 IRALVGSIDGSNIIRSEGKSCVSNAEKLSKKQVKNLINLGAKNILKKFK 291


>UniRef50_C0BZ93 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM
           15053 RepID=C0BZ93_9CLOT
          Length = 298

 Score =  318 bits (815), Expect = 2e-85,   Method: Composition-based stats.
 Identities = 118/296 (39%), Positives = 161/296 (54%), Gaps = 5/296 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           + +++RI +R+S LA+ QA  VK  +  + P +  E+V M T GD ILD  L   GGKGL
Sbjct: 1   MQSIIRIGSRESRLAVKQAEIVKQAVERNCPDIKAEIVTMKTEGDKILDRRLELAGGKGL 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FVKELE ALL+ R DI VHS+KDVP+E P+ L +V   EREDPRD  +     +  ++P 
Sbjct: 61  FVKELEKALLDGRIDICVHSLKDVPMEVPEDLPVVAFGEREDPRDVLIYKPGRT--SIPE 118

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G ++GTSS RR+ QL    P    RS+RGNV TRL KL    +D  +LA AGLKRL +E 
Sbjct: 119 GGVIGTSSRRRELQLKRLYPSCTFRSIRGNVQTRLRKLSEEGFDGTVLAAAGLKRLHMEE 178

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
                   +  +PAVGQG + ++ R         L +    ++     AER     L GG
Sbjct: 179 VAGRVFSVDEIIPAVGQGILAVQGRKGRDY--SWLTSFACGKSRAEAEAEREFAAALGGG 236

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           C  P+ ++A+    E+ L  L     G       R G    A Q+G +LAEE+   
Sbjct: 237 CTSPVAAHAQAQGAELKLTGLYYC-GGDIYRTRTRTGETDRARQLGAALAEEMRRE 291


>UniRef50_Q57989 Probable porphobilinogen deaminase n=11 Tax=Methanococcales
           RepID=HEM3_METJA
          Length = 292

 Score =  317 bits (812), Expect = 4e-85,   Method: Composition-based stats.
 Identities = 106/296 (35%), Positives = 156/296 (52%), Gaps = 10/296 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR S LAL+QA+ V + L     G  VE+  + T GD +LD  L+ +G  G+F KE
Sbjct: 2   IRIGTRGSKLALYQANKVAELLKNL--GYKVEIKIIKTTGDRVLDKKLSDIG-IGVFTKE 58

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L++A+L N  DIAVHS+KD+P  + + L +  + ER+   D  + N     +   +  ++
Sbjct: 59  LDLAMLNNEIDIAVHSLKDIPTIWNENLMVGAVLERDSYHDLLIWNKDIDFNE-DSKIVI 117

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS+RR+  L    P+     LRGNV TRL KL  G YDAI+L+ AG+ RLG+      
Sbjct: 118 GTSSMRRRAFLKFIYPNAKFELLRGNVDTRLRKLKEGLYDAIVLSEAGIIRLGVSLEDFN 177

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
               +I LPA  QG + + C+ DD   + +L  +NH  T L    ER       GGC VP
Sbjct: 178 YKRLDI-LPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSVP 236

Query: 246 IGSYAELIDGE--IWLRALVGAPDGSQIIRGERRGAPQD---AEQMGISLAEELLN 296
            G+ A   +    + L+A V   D  +   GE +    +   A ++G  +  +L N
Sbjct: 237 FGALAVYDEKNELLKLKAAVVTNDELKNASGEVKCKIDEIDKAVELGKKIGLKLKN 292


>UniRef50_A1DGB8 Porphobilinogen deaminase n=1 Tax=Neosartorya fischeri NRRL 181
           RepID=A1DGB8_NEOFI
          Length = 363

 Score =  316 bits (811), Expect = 5e-85,   Method: Composition-based stats.
 Identities = 120/342 (35%), Positives = 162/342 (47%), Gaps = 39/342 (11%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKL-MASHPGLVVELVPMVTRGDVILDTPLAKVG---- 57
           + V+    R+S LAL Q  +V  KL     P    ++      GD     P A +     
Sbjct: 20  EEVVIFGCRKSELALVQTRWVTSKLGQTLDPSPTFQIATGSAVGDADKQAPFAVLSKLTG 79

Query: 58  ----GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN-- 111
               GK L+  ELE+ L+  +    VHS+KD+P   P    L  + ERED  DA      
Sbjct: 80  GSDIGKSLWTNELELDLVAGKVHCLVHSLKDMPTTLPPHCLLGAVPEREDCSDAVCMRSD 139

Query: 112 -NYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE--YDAII 168
             + S+D LP GSIVGTSS RR+  +    P L +   RGNV TRL+KLD     +  I+
Sbjct: 140 LKFTSIDQLPPGSIVGTSSSRRKALVRRNWPHLEVVECRGNVDTRLAKLDAPSSRFSCIL 199

Query: 169 LAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRV 228
           LA AGL RLGL  RI   L   I   AVGQGA+G+E   D     EL+  ++H  +  R 
Sbjct: 200 LATAGLLRLGLGHRITHRLDDSIFPYAVGQGALGLEVSTDRPDILELVRHVDHKPSRWRG 259

Query: 229 TAERAMNTRLEGGCQVPIGSYAELI----------------------DGEIWLRALVGAP 266
            AERAM   L+GGC  PIG  + L                        G + LRA+V   
Sbjct: 260 IAERAMLRSLQGGCSSPIGVQSSLEPLGKEENGSTEDDSQRGRDSSSGGNLSLRAMVLHI 319

Query: 267 DGSQIIRGERRGAP---QDAEQMGISLAEELLNNGAREILAE 305
           +G+  I  E        ++AE +G+S+A  LL  GAR ++ +
Sbjct: 320 EGTSEIVAEDMATVRCDEEAELLGVSVANMLLAKGARGLMPK 361


>UniRef50_UPI0001BC2D4C glutamyl-tRNA reductase n=1 Tax=Brevibacterium linens BL2
           RepID=UPI0001BC2D4C
          Length = 825

 Score =  316 bits (810), Expect = 8e-85,   Method: Composition-based stats.
 Identities = 115/333 (34%), Positives = 169/333 (50%), Gaps = 30/333 (9%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
               +R+ TR+S LA  Q+  +  +L A   G  VE+V +VT GDV + +PL   GG G+
Sbjct: 475 SGRTIRLGTRRSKLARSQSTAIAHQLAAL-TGWRVEIVEVVTEGDVNM-SPLTGFGGTGV 532

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FV  +  AL + + DIAVHS+KD+P     G+ +  I  R DP D  +  +  S   LPA
Sbjct: 533 FVSAVRQALHQGKIDIAVHSLKDLPTTPEAGIQMAAIPPRVDPADVLIGRDGLSFAELPA 592

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           GS+VGT S RR  QL   RPD+ +R +RGNV TR++ + +G  DA++LA AG++R+G  +
Sbjct: 593 GSVVGTGSPRRAVQLRAARPDIEVRGVRGNVDTRIAHVRDGRLDAVVLAAAGVRRIGRLA 652

Query: 182 RIRAALPPEISLPAVGQGAVGIECR-------------LDDSRTRELLAALNHHETALRV 228
               +L  +  LPA GQGA+ +E R               D+  R  L  L+   T L V
Sbjct: 653 EATDSLDFDTMLPAPGQGALAVETRGADSPFALDNEVMEADAEVRTQLKRLHDETTDLAV 712

Query: 229 TAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER------------ 276
           T ERA+ +R E GC  PIG+ A +   +  + A++   DG      +             
Sbjct: 713 TCERAILSRAEAGCSAPIGALATIQGSDFVVDAVMADDDGKLARTRQVAPLPTTPDVDLD 772

Query: 277 RGAPQDAEQMGISLAE---ELLNNGAREILAEV 306
            G+       G  LA    EL    A ++L ++
Sbjct: 773 SGSANQLSITGKELARLADELGTAAAEDLLGQL 805


>UniRef50_D1C4S0 Porphobilinogen deaminase n=1 Tax=Sphaerobacter thermophilus DSM
           20745 RepID=D1C4S0_SPHTD
          Length = 311

 Score =  315 bits (809), Expect = 9e-85,   Method: Composition-based stats.
 Identities = 124/299 (41%), Positives = 161/299 (53%), Gaps = 2/299 (0%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +R+ TR S LA  Q   V   L A  P L +    + T GD    TPL  +GG+G+F +E
Sbjct: 11  VRLGTRGSALAREQTRRVMAALAALRPDLELIETIVSTAGDRDKRTPLTVIGGQGVFARE 70

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L+ ALL    D+AVHS KD+P E   GL +     RED RD  VS +  SL  LP G+ V
Sbjct: 71  LQTALLAGTVDVAVHSAKDLPTEPVPGLVIGAFFSREDARDVLVSRDGRSLADLPPGARV 130

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSS RR   L   RPDL    LRGN+ TRL K+  GE DA ILA AGL R+G +  I  
Sbjct: 131 GTSSRRRLVALRRLRPDLEAVDLRGNLDTRLRKVREGEVDAAILAAAGLLRMGWQEHITE 190

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L  +  +PA GQGA+ IECR DD    E+LAALN    AL    ER+    L GGC+ P
Sbjct: 191 FLSLDDFVPAPGQGALAIECRADDPAVNEMLAALNDPAAALAARTERSFLRALGGGCRSP 250

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN--NGAREI 302
           IG++A +    + LR ++G    +++          +AE    +LA E+     GA  +
Sbjct: 251 IGAHATVSGDTVTLRVMLGDEAMTRVRLSTWTLPAAEAETRAGALAVEVQRSLAGADPL 309


>UniRef50_O26960 Probable porphobilinogen deaminase n=1 Tax=Methanothermobacter
           thermautotrophicus str. Delta H RepID=HEM3_METTH
          Length = 289

 Score =  315 bits (808), Expect = 1e-84,   Method: Composition-based stats.
 Identities = 102/286 (35%), Positives = 153/286 (53%), Gaps = 4/286 (1%)

Query: 9   ATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEV 68
            TR S LAL Q ++V + L       + + +    +GD I D+ L  +  +GLF +EL++
Sbjct: 4   GTRGSRLALVQTNHVIEMLSEVCKEKIEKKIIKT-KGDRIRDSQLYSMDSRGLFTRELDM 62

Query: 69  ALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTS 128
           A+L    D+AVHS+KDVP +    L +  +  RE P +  VS      + LP GS +GTS
Sbjct: 63  AVLNEEVDLAVHSLKDVPSDLDPDLAIAAVPPRESPAEVLVSR--LDWEDLPQGSKLGTS 120

Query: 129 SLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALP 188
           SLRR+      + +  +  LRGN+ TR+ K+ +GE  A I+A AGLKRLGLE  I+   P
Sbjct: 121 SLRREAFCNHHQKNFKMEPLRGNIDTRIRKVMDGEVHATIMAEAGLKRLGLEEHIKRRFP 180

Query: 189 PEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGS 248
            E   PA GQGA+ +  R  DS     +  + HH +   VTAE+ +   L  GCQ P+G 
Sbjct: 181 VEYFTPAAGQGALAVITRA-DSELISSIGRITHHPSLQEVTAEKTLLRELGAGCQCPLGV 239

Query: 249 YAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
                  ++ L A++   +G  + +   RG   +AE +G   A+E+
Sbjct: 240 IGRATGNQLTLYAVLLTREGEMLRKVTVRGPLAEAEDIGKKAAKEM 285


>UniRef50_Q1EPC8 Porphobilinogen deaminase, chloroplast (Hydroxymethylbilane
           synthase) (Pre-uroporphyrinogen synthase), putative n=1
           Tax=Musa acuminata RepID=Q1EPC8_MUSAC
          Length = 328

 Score =  315 bits (808), Expect = 1e-84,   Method: Composition-based stats.
 Identities = 126/296 (42%), Positives = 163/296 (55%), Gaps = 34/296 (11%)

Query: 11  RQSPLALWQAHYVKDKLMASHPGLV----VELVPMVTRGDVILDTPLAKVGGKGLFVKEL 66
           R S LAL QA   +DKL A+H  L     VE++ + T GD+ILD PLA +GGKGLF KE+
Sbjct: 54  RDSDLALAQARETRDKLKAAHSELAEEGAVEIIIIKTTGDMILDKPLADIGGKGLFTKEI 113

Query: 67  EVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVG 126
           + ALL+ R DIAVHSMKDVP   P+G  L                               
Sbjct: 114 DDALLQGRIDIAVHSMKDVPTYLPEGTILPCNLP-------------------------- 147

Query: 127 TSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAA 186
            +SLRRQ Q+  R P L + +LRGNV TRL+KL NG+  A +LA+AGLKRL +   + + 
Sbjct: 148 -ASLRRQSQILCRYPSLKVVNLRGNVQTRLTKLKNGDVHATLLALAGLKRLNMVENVTSI 206

Query: 187 LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPI 246
           L  E  LPAV QGA+GI CR +D++  E L++LNH +T   V  ER   T L+G C+ PI
Sbjct: 207 LSMEEMLPAVAQGAIGIACRSNDNKMMEYLSSLNHEDTRSAVACEREFLTVLDGNCRTPI 266

Query: 247 GSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAP--QDAEQMGISLAEELLNNGA 299
            +YA    DG    R L+ +PDGS++    R G     D  +MG     EL     
Sbjct: 267 AAYAHRDKDGSCSFRGLLASPDGSKVYETTRIGPYSFDDMVEMGKDAGHELKAKAG 322


>UniRef50_C5CB88 Porphobilinogen deaminase n=5 Tax=Actinomycetales RepID=HEM3_MICLC
          Length = 377

 Score =  314 bits (806), Expect = 2e-84,   Method: Composition-based stats.
 Identities = 129/356 (36%), Positives = 179/356 (50%), Gaps = 61/356 (17%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           + LRI TR S LA  Q  +V + L A   GL  ELV + T GD +    LA +GG G+F 
Sbjct: 2   SPLRIGTRGSALATTQTSHVAEALTARS-GLAHELVVIRTEGD-VTTGSLASLGGTGVFA 59

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
             L  A+L+   D AVHS+KD+P   P+ L +  +  R D RDA  + +  +L  LP G+
Sbjct: 60  SALRAAVLDGVVDAAVHSLKDLPAAQPETLEIAAVPARADLRDALCARDGLTLATLPEGA 119

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL----------------DNGEYDAI 167
            VGT S RR  QL   RPDL +  +RGNV TRL+++                  G+ DA+
Sbjct: 120 RVGTGSPRRVAQLKALRPDLELVDIRGNVQTRLARVPGLEQHDDHAPAAVGSPRGDLDAV 179

Query: 168 ILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDS---------------RT 212
           ILA AGL RLGL+  I   + PE+ +PA GQGA+ +E R +D                R 
Sbjct: 180 ILACAGLDRLGLDHVITERIDPEVMVPAPGQGALAMEIRAEDESFLGRALLDPEAPVGRL 239

Query: 213 RELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDG-----EIWLRALVGAPD 267
              L  ++  +T + VTAERA+  RLE GC  PIG+ A + DG      I + A+V A D
Sbjct: 240 HAALELVDDRDTHVAVTAERALLRRLEAGCAAPIGAVARVGDGEAGAPRIEMTAMVAALD 299

Query: 268 GSQIIR-----------GERRGAPQ------------DAEQMGISLAEELLNNGAR 300
           GS+++R            +  G P              AE +G+ +AE+ +  GA 
Sbjct: 300 GSRVLRRTSSVQLDPVPADVVGDPAAADEWLEDTLFVAAEALGVHVAEQFVAEGAD 355


>UniRef50_B6JII8 Porphobilinogen deaminase n=11 Tax=Bradyrhizobiaceae
           RepID=B6JII8_OLICO
          Length = 338

 Score =  313 bits (802), Expect = 6e-84,   Method: Composition-based stats.
 Identities = 111/323 (34%), Positives = 159/323 (49%), Gaps = 18/323 (5%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG-L 61
           D  +RI TR+S +AL Q   +  +L A+ P L VE+V   T GD      L  +GGKG  
Sbjct: 11  DKAMRIGTRKSVMALAQTSEIARQLTAADPALDVEIVKFETTGDQDQTGKLLDLGGKGGA 70

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFP-QGLGLVTICEREDPRDAFVSNNYDSLDAL- 119
           FV ++  A+ E R + A+HS+KD+P      GL +     R+ P DA V  +  +L  L 
Sbjct: 71  FVAQIRDAVREGRLEAAMHSLKDMPGNEDTPGLVIGATLTRDPPTDALVVRHGVTLADLR 130

Query: 120 ---PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGE------------Y 164
                G  +GT+++RR   +    P+  I   RG   TR+ KLDNGE             
Sbjct: 131 RTGGKGFKIGTNAVRRAAYVRRLFPECEIIHFRGAADTRIRKLDNGEKQRLPEGGEVGPA 190

Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224
           DA+++A AGL+R+G   RI     P+  LPAVGQG V +EC   D  T   LA ++   +
Sbjct: 191 DALVMAQAGLERVGCADRIAHCFSPDEILPAVGQGIVAVECAASDWCTLARLAQIDDPVS 250

Query: 225 ALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAE 284
                AER +   L G C  PI  YA +   ++ L+A V        I   RRG      
Sbjct: 251 RCCAAAEREVLWVLNGHCNSPIAGYAIVEGDDVLLKAAVLDEANDHFIEVTRRGPASRPR 310

Query: 285 QMGISLAEELLNNGAREILAEVY 307
           ++G ++A ELL  GA +++A   
Sbjct: 311 ELGRAVAFELLAKGAADVIARTR 333


>UniRef50_C9RPT6 Porphobilinogen deaminase n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RPT6_FIBSS
          Length = 351

 Score =  312 bits (801), Expect = 9e-84,   Method: Composition-based stats.
 Identities = 128/346 (36%), Positives = 170/346 (49%), Gaps = 57/346 (16%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHP-------------GLVVELVPMVTRGDV 47
           M D  LRIATR+S LAL Q     D ++A++               L  ELV M T GD 
Sbjct: 1   MSDLKLRIATRKSALALAQTTMAADAIVAANSVIGNAADSNNARDSLTYELVSMTTEGDR 60

Query: 48  ILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDA 107
            LD  LA  GGKG+F+KELE+ALLE RADIA+HS+KD+P E      L  + +REDPRDA
Sbjct: 61  RLDKSLASFGGKGVFIKELEIALLEGRADIAIHSLKDMPAEVLPQFKLAAVLKREDPRDA 120

Query: 108 FVSNNYD---SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY 164
           F+S           LPAG+ VGT S+RR  QL   RPDL    +RGN+ TR+ KL   E 
Sbjct: 121 FLSRGGSAGIRFMDLPAGARVGTGSIRRVVQLKALRPDLEYVPIRGNIQTRIGKLA--EL 178

Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLD----------DSRTRE 214
           D ++LA AGLKR+GL  ++      E  LPA GQG + IE   D           +   +
Sbjct: 179 DGVVLAAAGLKRMGLADQVTEYFSTEQMLPASGQGILAIETLNDATVQESRVTGRADLAQ 238

Query: 215 LLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDG------------------- 255
           +LA +N   T    +AE A    L  GCQ P+ S+AE +                     
Sbjct: 239 ILARVNDVATYCIASAEMAYLKALNAGCQFPVASFAEFVCEDGIENRGTCGALEENANRI 298

Query: 256 --EIWLRALVGAPDGSQIIRGERRGAPQ--------DAEQMGISLA 291
              + +R +       +++R E  G            ++ +GI LA
Sbjct: 299 AQTLKIRGIYWDEKSEKLLRAEVAGNVDLNSEDCVQQSKNLGIELA 344


>UniRef50_Q6AHF1 Porphobilinogen deaminase n=5 Tax=Actinobacteria (class)
           RepID=HEM3_LEIXX
          Length = 329

 Score =  310 bits (796), Expect = 3e-83,   Method: Composition-based stats.
 Identities = 115/310 (37%), Positives = 158/310 (50%), Gaps = 15/310 (4%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LR+ TR SPLA+ Q   V   +  +  G  +ELV + T GD   +  L+++GG G+F   
Sbjct: 15  LRVGTRGSPLAVAQTQAVSAAVARA-TGFDIELVTVTTHGDTSRE-SLSELGGTGVFATA 72

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L  AL     D+ VHS+KD+P     GL L  + +R D RD   + +      LP G+ V
Sbjct: 73  LRDALRNGECDLVVHSLKDLPTAPAPGLVLGAVPKRADARDTLCARDGLRFGELPEGASV 132

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GT S RR  QL  +RP L I  +RGNV TRLS++  G+ DA++LA AGL RLG       
Sbjct: 133 GTGSPRRAAQLRAQRPGLDIVDIRGNVDTRLSRVSAGDLDAVVLAAAGLGRLGRLDAATD 192

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSR----TRELLAALNHHETALRVTAERAMNTRLEGG 241
                    A GQGA+ +E R  D R        LAA++H  T    TAERA+   LE G
Sbjct: 193 FFSLSTMPTAPGQGALALEVREGDERGRGPIARALAAVDHATTCAATTAERAVLAGLEAG 252

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQD---------AEQMGISLAE 292
           C  P+G+ A + DG ++L A V  PDG+  +       P           A  +G  +  
Sbjct: 253 CAAPVGATAMIDDGLLFLTATVYRPDGAAQLTASHAATPDSFGAAHLDEAARDVGERVVA 312

Query: 293 ELLNNGAREI 302
           ELL +GA ++
Sbjct: 313 ELLASGAADL 322


>UniRef50_A3VPD5 Porphobilinogen deaminase n=1 Tax=Parvularcula bermudensis HTCC2503
           RepID=A3VPD5_9PROT
          Length = 324

 Score =  308 bits (791), Expect = 1e-82,   Method: Composition-based stats.
 Identities = 135/286 (47%), Positives = 178/286 (62%), Gaps = 6/286 (2%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMAS------HPGLVVELVPMVTRGDVILDTPLA 54
           M    LRIA+R+SPLA+ QA +V+D+L  +                 VT GD +L+  LA
Sbjct: 1   MSFKPLRIASRRSPLAVAQALWVRDRLAEALGIDEVDRDAAFPHETFVTTGDRMLNPTLA 60

Query: 55  KVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD 114
            +GGKGLF KE+E+ALL+ +ADIAVHSMKD+P + P GL L  +  REDPRDAFV+ +  
Sbjct: 61  DIGGKGLFTKEIEIALLDGQADIAVHSMKDMPAQMPPGLVLAAVPVREDPRDAFVTLDGR 120

Query: 115 SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174
            LD +PAG+ +GTSS RR+ QLA  RPDL +  +RGNVGTRL KL  GE +   LA AGL
Sbjct: 121 PLDQMPAGARIGTSSTRRRAQLARLRPDLALVPMRGNVGTRLQKLAAGEAEGTFLAEAGL 180

Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234
           +RLG+    R AL P   LPA+GQGA+ ++ R  D  T    A +N+  TAL   AERA+
Sbjct: 181 RRLGMTDVKREALSPARMLPALGQGALCVQARSGDHETLSACAHINNRPTALAAAAERAL 240

Query: 235 NTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAP 280
            + L+G C+ PIG  A      + L   +  PDG +++RGER  A 
Sbjct: 241 ISGLDGSCKTPIGGLARQTGDSLILEGQILTPDGRRVLRGERTVAI 286


>UniRef50_A8PWJ5 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS
           7966 RepID=A8PWJ5_MALGO
          Length = 530

 Score =  308 bits (791), Expect = 1e-82,   Method: Composition-based stats.
 Identities = 131/394 (33%), Positives = 187/394 (47%), Gaps = 92/394 (23%)

Query: 5   VLRIATRQSPLALWQAHYV------------------------------KDKLMASHPG- 33
            L +++R+S LA+ QA  V                              +  L    P  
Sbjct: 89  TLVLSSRKSELAVRQATQVQMLLDTRYGRASPVFAPGADQWPSTEVANIRAFLRTFSPDQ 148

Query: 34  -----LVVELVPMVTRGDVILDTPLAKVGGKG--LFVKELEVALLENRADIAVHSMKDVP 86
                +   +  M T GD  L +PL  +GG+G  ++ KELEVAL+    D  VHS+KDVP
Sbjct: 149 KDVRPVDFPVRTMATLGDQNLKSPLYVIGGEGRAIWTKELEVALMAGGVDAIVHSLKDVP 208

Query: 87  VEFPQGLGLVTICEREDPRDAFVSN---NYDSLDALPAGSIVGTSSLRRQCQLAERRPDL 143
              P G+ L  I EREDPRDA V      Y SL  +P GS++GTSS+RR   L    P L
Sbjct: 209 TTMPDGVELAAILEREDPRDALVVKENLPYKSLQEMPQGSVIGTSSVRRVSLLRRAYPHL 268

Query: 144 IIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAV 201
           +   +RGN+ TRL+KLD  +G Y A++LA AGLKR+ LE RI A +   + L AVGQG++
Sbjct: 269 MFSDVRGNINTRLAKLDAADGPYTALVLAAAGLKRMDLEHRITAYVSEPVMLHAVGQGSL 328

Query: 202 GIECR-------LDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELI- 253
            IE R         D R R ++ ++++     R  AERA+  R+EGGC +P+G       
Sbjct: 329 AIEVRTPRGESAERDERIRRMIRSISNWRATWRCVAERALMHRMEGGCSIPLGVSTRFED 388

Query: 254 -------------------------------------DGEIWLRALVGAPDGSQIIRGER 276
                                                   + + A++ + DG+++ +   
Sbjct: 389 HADIEGLLNERNETPSEMASAGISRPDIRIAHEPPPQGSFLTMAAVIVSLDGTRMCKHSH 448

Query: 277 R---GAPQDAEQMGISLAEELL-NNGAREILAEV 306
                + +DAEQ+GI +AEEL  +  AR ILAEV
Sbjct: 449 TQLCRSEKDAEQLGILVAEELEHHQNARAILAEV 482


>UniRef50_C5EV71 Pyruvate ferredoxin/flavodoxin oxidoreductase n=3 Tax=Clostridiales
           RepID=C5EV71_9FIRM
          Length = 301

 Score =  308 bits (789), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 119/305 (39%), Positives = 165/305 (54%), Gaps = 15/305 (4%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           + N++RI TR+S LAL Q H + D L  + P + VELV   T GD ILD PL + GGKG+
Sbjct: 1   MSNIIRIGTRKSALALIQTHLIADGLKRAWPDIEVELVTKETLGDKILDKPLQEFGGKGV 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           FV E E A+ E   D+AVHS KD+P+E  +GL +  +  R DPRD  V+      D    
Sbjct: 61  FVSEFEQAMKEGAIDLAVHSAKDLPMELGEGLVIAAVSGRGDPRDVLVTMKGSPKDR--E 118

Query: 122 GSIVGTSSLRRQCQLAERR-------PDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGL 174
             ++GTSS RRQ +  E R         L   +LRGNV TRL KL+ G YD IILA AGL
Sbjct: 119 HIVIGTSSPRRQLEAVEYRGQLWPGAASLTCATLRGNVHTRLRKLEEGLYDGIILAAAGL 178

Query: 175 KRLGLESRIRA---ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231
           +RL L          L P + +PA GQG + +E R      R L  A++  E  L +T E
Sbjct: 179 ERLDLLGNPSYDFKYLDPTVFIPAGGQGIMAVEAREGSDAAR-LCQAIDSREGRLCLTLE 237

Query: 232 RAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDG-SQIIRGERRGAPQDAEQMGISL 290
           R +   L+ GC  PIG Y+ ++DG++ +   +  PD  ++ I  E     ++ E + +  
Sbjct: 238 RMVLKLLDAGCHEPIGIYSNIMDGKMEVWG-ISRPDRVTRRISLEGAVTEKELEALALQA 296

Query: 291 AEELL 295
              L+
Sbjct: 297 GRGLM 301


>UniRef50_B2ULP1 Porphobilinogen deaminase n=1 Tax=Akkermansia muciniphila ATCC
           BAA-835 RepID=B2ULP1_AKKM8
          Length = 325

 Score =  306 bits (784), Expect = 8e-82,   Method: Composition-based stats.
 Identities = 121/317 (38%), Positives = 157/317 (49%), Gaps = 21/317 (6%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVG---- 57
             N L I TR S LAL QA  V+  L   +P L V    + T GD   D PLA V     
Sbjct: 3   SKNTLIIGTRGSALALAQADMVRAALSLRYPELDVRCEIIHTIGDRRTDVPLADVARVSG 62

Query: 58  --GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS 115
              KG+F+KELE AL + R D+AVHS+KDVP E   G  L  +  R    D  ++   D 
Sbjct: 63  MVDKGIFIKELETALRDGRIDVAVHSLKDVPSELAAGFTLAAVLPRAAVEDVLITKEPDW 122

Query: 116 LDALPAGSIVGTSSLRRQCQLAERR-PDLIIRSLRGNVGTRLSKL-DNGEYDAIILAVAG 173
             +      + T S+RR+          L   +LRGNV TRL KL ++  +DA+ILA AG
Sbjct: 123 NGS----GTLATGSVRRRLMARTYWGSGLRFENLRGNVPTRLGKLVEHPGWDAVILARAG 178

Query: 174 LKRLGLESRIR---------AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224
           L+RLGL +              LP E+ +PAVGQG VG+ECR  D  T E+L  +N  E+
Sbjct: 179 LERLGLYAPETLVEGRKLYMRPLPVEVFIPAVGQGIVGMECRSSDRETAEMLEGINDPES 238

Query: 225 ALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAE 284
                AERA   RL   C  P+G YA     E+ LRA    P   +      RG  +  E
Sbjct: 239 FACALAERAFLVRLGANCSTPVGVYAHPDGEELVLRAAYYVPGREEPFAVVIRGDRKAPE 298

Query: 285 QMGISLAEELLNNGARE 301
            +G+   EEL  +G R+
Sbjct: 299 ALGLRAFEELGLSGWRK 315


>UniRef50_A2SQU4 Uroporphyrin-III C-methyltransferase n=11 Tax=Euryarchaeota
           RepID=A2SQU4_METLZ
          Length = 542

 Score =  305 bits (783), Expect = 1e-81,   Method: Composition-based stats.
 Identities = 119/308 (38%), Positives = 165/308 (53%), Gaps = 22/308 (7%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           + +RI TR S LAL Q   V   L  +  G+  E V + T GD + D  L ++GG G+FV
Sbjct: 2   SKIRIGTRGSKLALAQTKKVIGLLAEN--GIDAEYVIIKTTGDKVTDRGLHQIGGFGMFV 59

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           +EL+ A+L    D AVHSMKD+P E P+GL  V + +R+ P D  V N    ++ L    
Sbjct: 60  RELDNAILRGEIDCAVHSMKDIPAERPKGLLTVAVLKRDPPYDFLVMN--GKVEDL---M 114

Query: 124 IVGTSSLRRQCQLAERR---PDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
           ++GTSSLRR+ QL       P + +  LRGN+ TRL KLD+G YD I++A AGL RL  +
Sbjct: 115 VIGTSSLRRKAQLLRYFHNCPAVRVEMLRGNLDTRLGKLDDGLYDGIMVAEAGLMRLDYK 174

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            R    L P++ +PA  QG + I  R D    R   A LN  ++AL    ER +  ++ G
Sbjct: 175 -RNGVRLSPDMFVPAANQGTIAIVSR-DTPELRAAFAPLNDPQSALDCAIERIVMEQVGG 232

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-GAPQDAEQMGISLAEELLNNGA 299
           GC  P+G + E       L A V + DG++  R     G  + A   GI     L N GA
Sbjct: 233 GCFTPMGIFCENQ----HLTAEVLSLDGTRAERITAEIGDLEGARVAGI----RLKNVGA 284

Query: 300 REILAEVY 307
            E++AE  
Sbjct: 285 -ELIAEAK 291


>UniRef50_A6LKX0 Porphobilinogen deaminase n=1 Tax=Thermosipho melanesiensis BI429
           RepID=A6LKX0_THEM4
          Length = 279

 Score =  305 bits (781), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 94/247 (38%), Positives = 141/247 (57%), Gaps = 6/247 (2%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            +R+ TR+S LAL Q   V +KL    P +  E+ P+VT+GD  L TP+ K+GGKG+FV 
Sbjct: 2   KIRVGTRKSKLALIQTQLVVNKLKELLPNIDFEITPVVTKGDR-LKTPIDKIGGKGVFVS 60

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           ++E  +L+++ DIA+HSMKD+P + P  L L ++ +RE P D F+     +   L  G+ 
Sbjct: 61  DIEKLILDDKLDIAIHSMKDLPSKIPDKLFLTSVLKRECPNDVFIGKE--NFFNLKKGAK 118

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GTSS RR  Q+   RPD+ I  +RGNV TR+ K+  GE D I++A AG+ RLGL+ +I 
Sbjct: 119 IGTSSKRRALQINMLRPDIEIVPIRGNVDTRIKKI--GELDGIVIAAAGVIRLGLKDKIT 176

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSR-TRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
                E  +PA  QG + +E      +   E+   +   +T +    ER + + L   C 
Sbjct: 177 NLFEFEKIVPAPCQGILALEFSEKFLKPFEEIKDVIVDPKTEVETQIERKILSLLNFDCN 236

Query: 244 VPIGSYA 250
            P G Y 
Sbjct: 237 TPFGFYC 243


>UniRef50_Q6L2G8 Probable porphobilinogen deaminase n=1 Tax=Picrophilus torridus
           RepID=HEM3_PICTO
          Length = 282

 Score =  304 bits (779), Expect = 3e-81,   Method: Composition-based stats.
 Identities = 105/255 (41%), Positives = 151/255 (59%), Gaps = 8/255 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR S LA+ QA  VKD+L +   G+  E+    ++GD+ LD+PL  +GG G+FV +
Sbjct: 3   IRIGTRSSKLAMIQAMMVKDRLDSL--GIETEVKGFTSKGDINLDSPLYSIGGTGVFVDD 60

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L   +L+N  DIAVHS KD+P      L +  + +R+DPRD  +S +  SL+ L A S++
Sbjct: 61  LNRMILKNEIDIAVHSAKDIPSFIDDSLEISAVLKRDDPRDVLISQH--SLNDLEASSVI 118

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSSLRR  +L   R D++I+ LRGN+ TRL KLDNG+YD II+A A   R+   +R   
Sbjct: 119 GTSSLRRIKELKTLRNDILIKDLRGNIDTRLKKLDNGDYDGIIMAKAAYDRM-RINRRHF 177

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            L  +  +PA  QG + I     DS   ++L  +N  ET   + AER + + L  GC  P
Sbjct: 178 ILNYDDFVPAPNQGIIAI-ISKKDSEINDVLKKINDDETYNDMKAERLILSGLNLGCSKP 236

Query: 246 IGSYAELIDGEIWLR 260
           +G YA      I++R
Sbjct: 237 VGIYAH--KNRIFMR 249


>UniRef50_C7DH16 Porphobilinogen deaminase n=1 Tax=Candidatus Micrarchaeum
           acidiphilum ARMAN-2 RepID=C7DH16_9EURY
          Length = 301

 Score =  303 bits (777), Expect = 5e-81,   Method: Composition-based stats.
 Identities = 108/306 (35%), Positives = 169/306 (55%), Gaps = 7/306 (2%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M ++ + I TR S LA+ QA  V++KL A  P +   +V + T  + + D   A+   K 
Sbjct: 1   MSESEITIGTRGSELAVAQAEIVRNKLAAIEPRISFRIVKIKTLNEKV-DRSKART-EKD 58

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           ++ KE++ A+LE R DIAVHS+KD+     + + +  + +R+DPRD F+ N     + L 
Sbjct: 59  IYTKEIDEAILERRIDIAVHSLKDLKFNMDENMQIGAVPDRDDPRDVFIGNTETEFEHLG 118

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
             ++VGTSS+RR+ QL    P  +I  L GN+ TRLSKL++GE+  I++A AG+KRLG  
Sbjct: 119 TDALVGTSSIRRRVQLTRINPKPMISDLHGNIDTRLSKLNSGEFSGIVIAAAGVKRLGKA 178

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
            R+         +PA+GQGA+ +    D+S   ELL  +++ +  + V  E         
Sbjct: 179 VRM-QYFDERDVVPAIGQGAIAVTVHKDNSAAAELLKRIDNMKARVEVGEEIEFGKAFGT 237

Query: 241 GCQVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGA 299
           GC +PIG+ A+ L  G+I +   V    G  +++GE    P  A   G SLAE L+  GA
Sbjct: 238 GCNLPIGANAKMLESGKIGIVGFVSDLAGKTLVKGETETGPGHA---GKSLAELLIKKGA 294

Query: 300 REILAE 305
             ++  
Sbjct: 295 GNLIER 300


>UniRef50_C6V4N6 Porphobilinogen deaminase n=2 Tax=Neorickettsia RepID=C6V4N6_NEORI
          Length = 286

 Score =  303 bits (777), Expect = 5e-81,   Method: Composition-based stats.
 Identities = 113/292 (38%), Positives = 163/292 (55%), Gaps = 9/292 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           L++  R S LAL QA  V+  L      +   LV + T GD++ D PL +VGGK LF+KE
Sbjct: 4   LKVGARCSTLALAQARLVERALAPYCERID--LVGVRTSGDILSDIPLTEVGGKALFLKE 61

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           LE  LL    DIAVHSMKDVP  +   L +V + +R  P D FVS  Y ++ +LP+G+++
Sbjct: 62  LEEKLLTGEIDIAVHSMKDVPAFYHDDLEVVPVLKRAIPNDVFVSFRYPNMLSLPSGAVI 121

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GT + RR  QL +R     +  LRGN+ TR+ K  N   D IILA  GL+RLGL   I  
Sbjct: 122 GTCAPRRVVQLNQRF---RVIPLRGNIATRVEKAKN--LDGIILAFCGLERLGLCKMISE 176

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVP 245
            +  ++ LP V QGA+ +E R  D   REL+  ++  ET +  TAERA    + G C+  
Sbjct: 177 VIHEDVMLPGVAQGALCVEFRKKDHFLRELILNISDRETIICTTAERAFLEEINGDCKTA 236

Query: 246 IGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           +G+ A + +  ++   ++G  +     R    G+  +A+Q+G S A  LL  
Sbjct: 237 LGALAVVKNNTLYFTGMLGKDNRPCYFRTS--GSCLNAKQIGRSAALALLRM 286


>UniRef50_B3LB83 Porphobilinogen deaminase, putative n=1 Tax=Plasmodium knowlesi
           strain H RepID=B3LB83_PLAKH
          Length = 449

 Score =  303 bits (776), Expect = 7e-81,   Method: Composition-based stats.
 Identities = 102/382 (26%), Positives = 168/382 (43%), Gaps = 73/382 (19%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHP----GLVVELVPMVTRGDVILDTPLAKVGGK 59
             + I TR SPLA+ Q+  V+ KL A        + + L  + T GD ILD  +   GGK
Sbjct: 65  KEIIIGTRDSPLAIKQSEKVRTKLEAYFKKVNKNVKITLKSIKTMGDNILDQKVDLFGGK 124

Query: 60  GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119
           G+F KEL+  L++ +  I VHS+KDVP+E P+ + L    +R+   DAF+S  Y +L+ +
Sbjct: 125 GIFTKELDEELIKGKVHICVHSLKDVPMELPEQVQLSCFLKRDTINDAFLSVKYGTLEDM 184

Query: 120 ---------------PAGS------------------------IVGTSSLRRQCQLAERR 140
                          P G                          +GTSSLRR  Q+  + 
Sbjct: 185 NKMKMANKMEEGSYQPKGMSQRVINQNVKRDNYEGDHYDNFIPTIGTSSLRRSSQIKYKY 244

Query: 141 PDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL----------------------- 177
            ++ ++++RGN+ TR++KL NG+YDAII+A  GL+RL                       
Sbjct: 245 KNVAVKNMRGNINTRIAKLCNGQYDAIIIAKCGLERLTTKKGIRNIIGGKNKVTPKNFLI 304

Query: 178 -------GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTA 230
                   L S     +      PA+ QG + +     D    ++L  +N  +  +    
Sbjct: 305 NYNNTEINLTSLHIQQINKRTIYPALCQGIIAVSSHKSDKYISDVLKNINDEKAQIMANI 364

Query: 231 ERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISL 290
           ER+   ++EG C +PIG YA++++GEI   A++    G +       G  +   ++ +  
Sbjct: 365 ERSFLYQIEGNCMMPIGGYAKIVNGEIVFNAVINDIHGREKYHVREVGKVESYNEIAVMA 424

Query: 291 AEELLNNGAREILAEVYNGDAP 312
           A ++          ++    A 
Sbjct: 425 ATKMKEKIGTHRFNKIREEAAQ 446


>UniRef50_D1B7N1 Porphobilinogen deaminase n=1 Tax=Thermanaerovibrio acidaminovorans
           DSM 6589 RepID=D1B7N1_THEAS
          Length = 307

 Score =  303 bits (776), Expect = 7e-81,   Method: Composition-based stats.
 Identities = 114/298 (38%), Positives = 159/298 (53%), Gaps = 12/298 (4%)

Query: 10  TRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVA 69
           TR SPLA+ QA   KD++ +   G  V L+ + T GD      LA  GG G FVK LE  
Sbjct: 8   TRSSPLAMAQARMWKDRIESL--GHSVRLLDVSTHGDRDRRRHLACFGGFGAFVKALEDR 65

Query: 70  LLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSS 129
           LL  +   AVHS+KDVP   P GL +  + ER    D  V+    SL+ LP+G+++GTSS
Sbjct: 66  LLSGQGHGAVHSLKDVPSVQPDGLVIAGVLERGPRGDVLVTREGLSLEELPSGAVIGTSS 125

Query: 130 LRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPP 189
           +RR  Q+   R DL +   RGNV +RL KL+ G +  I+LA AGL+RLG    IRA +  
Sbjct: 126 IRRAAQVRMLRGDLNVECCRGNVHSRLRKLEQGLFHGIVLARAGLERLG----IRAPMAE 181

Query: 190 EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSY 249
              + + GQGAV +E R   S    L A L H  T L V AER+       GC  P+ + 
Sbjct: 182 LPFITSPGQGAVALEAREG-SELHLLGARLTHRSTWLEVLAERSFLKAFGMGCSAPVAAS 240

Query: 250 AELIDGEIWLRALVGAPDGSQIIRGERRGAP---QDAEQMGISLAEELLNNGAREILA 304
           A +    + L+  V +P+G+     E    P   +DA  +G +   E+  +G+ E+L+
Sbjct: 241 AVMDRDTLTLKVQVLSPNGTSAAEAEVSCVPWGEEDAYALGEAAFREI--SGSPEVLS 296


>UniRef50_Q5KKQ0 Hydroxymethylbilane synthase, putative n=2 Tax=Filobasidiella
           neoformans RepID=Q5KKQ0_CRYNE
          Length = 481

 Score =  302 bits (773), Expect = 2e-80,   Method: Composition-based stats.
 Identities = 105/289 (36%), Positives = 141/289 (48%), Gaps = 37/289 (12%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPG-------------------------LVVE 37
            N   + TR+S LAL Q  +V D L   H G                             
Sbjct: 30  TNTFILGTRKSNLALVQTGHVADDLRRLHSGAGSKFGETREEGDDAEQGDVPFVHPYTFS 89

Query: 38  LVPMVTRGDVILDTPLAKV-------GGKGLFVKELEVALLENRADIAVHSMKDVPVEFP 90
           +  M T GD    TPL  +         K L+  ELE  L+    D+ VHS+KDVP    
Sbjct: 90  IESMTTVGDRNQTTPLHLLSPYSSTQPAKSLWTDELEARLINGHFDMLVHSLKDVPTVLK 149

Query: 91  QGLGLVTICEREDPRDAFVSNNY---DSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRS 147
            G  +  + +R DPRDA V         L+ LP G++VGT S+RR  QL    P+L+   
Sbjct: 150 DGCEIGCMAKRHDPRDALVVKQGLPYKRLEDLPDGAVVGTGSVRRVAQLKRAFPNLVFED 209

Query: 148 LRGNVGTRLSKLDNGE--YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIEC 205
           +RGN+ TR +KLDN +  + A+ILA++GL+RLG+  R  + L     + AVGQGA+ IE 
Sbjct: 210 MRGNLNTRFNKLDNPQSPFSALILAMSGLERLGMAHRATSPLSSPTLMHAVGQGALAIEI 269

Query: 206 RLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID 254
           R  D R R  L  L H +T     AER     LEGGC VP+G  +EL++
Sbjct: 270 RSTDPRVRNCLRGLGHWQTEWSCGAERGCLRVLEGGCSVPVGVESELVE 318



 Score = 48.2 bits (114), Expect = 4e-04,   Method: Composition-based stats.
 Identities = 17/57 (29%), Positives = 26/57 (45%), Gaps = 4/57 (7%)

Query: 256 EIWLRALVGAPDGSQIIRGE----RRGAPQDAEQMGISLAEELLNNGAREILAEVYN 308
           ++ L + V + DGS+ +          + + AEQ G   A  L   GA EIL E+  
Sbjct: 386 KLTLHSCVTSTDGSKHVLFTPPPVLVRSYRQAEQFGEECARRLRGMGAGEILDEINK 442


>UniRef50_Q0ATQ1 Porphobilinogen deaminase n=3 Tax=Alphaproteobacteria
           RepID=Q0ATQ1_MARMM
          Length = 321

 Score =  302 bits (773), Expect = 2e-80,   Method: Composition-based stats.
 Identities = 129/305 (42%), Positives = 165/305 (54%), Gaps = 14/305 (4%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASH------PGLVVELVPMVTRGDVILDTPLAKV 56
              L IATR+SPLAL QA  V+ KL A              ++ +V+ GD I D  L + 
Sbjct: 5   SRPLAIATRRSPLALVQARDVQAKLAAQCGLSGEDAERCFPILGLVSTGDRIQDRTLIEA 64

Query: 57  GGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS- 115
           GGKGLF KE++ A L+ RA  AVHSMKDVP   P G+ L  + EREDPRD  ++ + ++ 
Sbjct: 65  GGKGLFTKEIDEAQLDGRAAFAVHSMKDVPTVLPDGIVLGALLEREDPRDMLIARDGETR 124

Query: 116 LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLK 175
           L  LP G  +GT+SLRRQ QL  +RPDL +  LRGNV TRL KL +G   A  LA AGL 
Sbjct: 125 LADLPEGVTIGTASLRRQAQLLHKRPDLHVVPLRGNVDTRLGKLADGGIHATFLARAGLN 184

Query: 176 RLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMN 235
           RLG    +R  L  +  LPA  QGAVG+  R  D      +A L+H +T L V AERA  
Sbjct: 185 RLGRAEALRDPLEADEMLPAAAQGAVGVAIRDGDEEAASYVAGLHHRDTELAVLAERAFL 244

Query: 236 TRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR-----GAPQDAEQMGISL 290
             L+G C+ PI ++  +    +     V  PDG Q  R + R       P  A Q G  L
Sbjct: 245 FELDGSCRTPIAAH--VNKVSMDFIGEVLTPDGQQSWRRQIRFDMTHATPDSARQAGQDL 302

Query: 291 AEELL 295
              + 
Sbjct: 303 GRAVR 307


>UniRef50_B5GJG2 Porphobilinogen deaminase n=3 Tax=Streptomyces RepID=B5GJG2_9ACTO
          Length = 335

 Score =  300 bits (770), Expect = 3e-80,   Method: Composition-based stats.
 Identities = 113/309 (36%), Positives = 153/309 (49%), Gaps = 12/309 (3%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTP----LAKVGGK 59
             + + +R S LA  Q   + ++     PG+      +   GD    TP    + +  G 
Sbjct: 31  RTVTVGSRGSALARAQVREMVERWEREVPGVRFVRRVITEAGDADRSTPTVAGVTRRAGV 90

Query: 60  GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTIC-EREDPRDAFVSNNYDSLDA 118
             F    E AL+    D+ VH +KD+P     G  L+     RED RDA       +L  
Sbjct: 91  SAFSSRQEAALVRREVDVVVHCLKDLPTTPAPGTALLRTPGPREDARDALC---GATLAG 147

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178
           LP G+ VGT S RR  QL   RPDL +  +RGNV  RL++L     DA++LA AGL RLG
Sbjct: 148 LPRGARVGTGSTRRVAQLLALRPDLEVIPVRGNVPARLARLRT--LDAVVLAAAGLHRLG 205

Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
           L   I   L PE   PA GQGA+ I+ R   S    LLAA     T   V AER +   L
Sbjct: 206 LTEEITEYLDPEAYPPAPGQGALAIQVREG-SGAARLLAASGDPATDTEVRAERVLLAEL 264

Query: 239 EGGCQVPIGSY-AELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
            GGC VP+G++ +    G + L A V APDG + I    +G   + +++ +++AE LL  
Sbjct: 265 HGGCSVPLGTWTSRPSPGTLRLHAAVTAPDGGRQITATAQGPASEPDKLALTVAERLLAG 324

Query: 298 GAREILAEV 306
           GA  ILAE 
Sbjct: 325 GAARILAEA 333


>UniRef50_C7M2H5 Porphobilinogen deaminase n=1 Tax=Acidimicrobium ferrooxidans DSM
           10331 RepID=C7M2H5_ACIFD
          Length = 291

 Score =  300 bits (768), Expect = 5e-80,   Method: Composition-based stats.
 Identities = 123/299 (41%), Positives = 171/299 (57%), Gaps = 14/299 (4%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            +RIATR+S LA WQA  V ++L         ELV + T GD    + LA++GG+G+FVK
Sbjct: 3   PVRIATRRSALARWQASLVGERLGR------YELVEVHTAGDRDQASSLAEIGGQGVFVK 56

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           E++ A++   ADIAVHS KD+P      L L  + ER D RDA V      L+ L  G+ 
Sbjct: 57  EVQAAVVRGEADIAVHSAKDLPTAAGP-LLLAAVLERADARDAIV---GARLEELAIGAR 112

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGTS+ RR  QL   RPDL + S+RGN+ TRL ++  GE DAI++AVA L+RLGLE    
Sbjct: 113 VGTSAPRRAAQLRLLRPDLEVVSIRGNIATRLGRV--GELDAIVMAVAALERLGLEEPPW 170

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             LP E+  P  GQGA+ +EC  D     E L +L+   +   + AERA+      GC +
Sbjct: 171 WPLPEEVLCPQAGQGAIAVECAPDADGLIERLRSLDDDRSRREIEAERAVLAAFGTGCAL 230

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
           P+G+ A      + LRA+   PDG++ +  ER G   D   +G ++AE L   GA  ++
Sbjct: 231 PLGARAHADGSSLRLRAVAVDPDGTRQLEVEREGV--DPATLGATVAEVLRRLGADALV 287


>UniRef50_Q1AUK3 Porphobilinogen deaminase n=1 Tax=Rubrobacter xylanophilus DSM 9941
           RepID=HEM3_RUBXD
          Length = 305

 Score =  299 bits (767), Expect = 8e-80,   Method: Composition-based stats.
 Identities = 134/306 (43%), Positives = 175/306 (57%), Gaps = 5/306 (1%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   L + TR SPLAL QA      L A+  G  VEL  + T  D   D PL+ +  + +
Sbjct: 1   MAGRLVLGTRGSPLALAQAEACAAGLRAA--GFAVELRRIRTTSDRRPDDPLSVIDQRDV 58

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F ++L+ ALL    D+AVHSMKDVP E P+G+ L  +  R DP DA VS     +D LP 
Sbjct: 59  FTRQLDEALLAGEVDLAVHSMKDVPTEVPEGIVLAAVAGRADPSDALVSEGGWGVDGLPE 118

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           G+ V TSSLRR+ QL  RRPDL +  +RGNV TR+ K+  G  +A++LA AGL RLGLE 
Sbjct: 119 GARVATSSLRRRAQLLHRRPDLRVVEIRGNVDTRIRKMRAGAAEAVVLARAGLVRLGLE- 177

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
              A +P ++ LPAVGQGA+ +  R  D R  E+  ALN       V AERA+   LEGG
Sbjct: 178 VPHAVIPHDVLLPAVGQGALAVAVRRGDPRLEEIRRALNDPAAEREVAAERALLRALEGG 237

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           C+VP+G+ A      + LR +V +PDG+ +  GE RG   +       LA  LL  GA  
Sbjct: 238 CRVPVGARAVAGGRGVLLRGVVVSPDGAALCGGEERGEEPEEVG--RRLAARLLERGAAG 295

Query: 302 ILAEVY 307
           IL  V 
Sbjct: 296 ILGFVR 301


>UniRef50_A4YD92 Probable porphobilinogen deaminase n=1 Tax=Metallosphaera sedula
           DSM 5348 RepID=HEM3_METS5
          Length = 290

 Score =  298 bits (764), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 110/297 (37%), Positives = 153/297 (51%), Gaps = 14/297 (4%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            +RIA R S L+L Q   V   L A   G   E + + T+ D+  + PL ++G KG+F K
Sbjct: 2   KIRIAARGSKLSLKQVEIVTTYLQAK--GYETEFIEIKTKADLFGNKPLHEIG-KGVFEK 58

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           E+  A+L+ RADIAVHSMKD+  E P GL L+   +RE+P D  VS    +L+ LP  S 
Sbjct: 59  EVNEAVLQGRADIAVHSMKDMSSELPPGLELLATPKRENPVDVLVSE--LNLEELPEKSR 116

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GT SLRR   L   RPDL++ ++RGNV TRL K  + EYD IILA AGL+RLG+E + R
Sbjct: 117 IGTGSLRRANFLKVVRPDLVVENIRGNVDTRLRKYRDHEYDGIILAEAGLRRLGVEVK-R 175

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L  E   P   QG + +       +   L   LN   T     AE+     + GGC  
Sbjct: 176 FPLDVESFTPEPNQGIIAVV---GSPKFLGLFQELNDTGTMKEALAEKETVKVVGGGCHS 232

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRG---ERRGAPQDAEQMGISLAEELLNNG 298
           P+G    L D    L  +    +G + +      R        Q+G +L + + + G
Sbjct: 233 PLGVLFRLEDDV--LHGIASYSNGVKRVTVKLSTRESPQIAGNQLGKALVKAMKDEG 287


>UniRef50_C7R376 Porphobilinogen deaminase n=1 Tax=Jonesia denitrificans DSM 20603
           RepID=C7R376_JONDD
          Length = 344

 Score =  298 bits (763), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 126/344 (36%), Positives = 172/344 (50%), Gaps = 47/344 (13%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LR+ TR S LA  Q+      L+A   G+ V+L  + T GD +L   LA +GG G+FV  
Sbjct: 4   LRLGTRASALATAQSRATA-ALIAQATGVTVDLTHIRTDGD-VLTGSLATMGGAGVFVTA 61

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           +  ALL    DIAVHS+KD+P    +G  ++ + ERE+P+DA  S + +SL  LP G++V
Sbjct: 62  IRQALLAGDIDIAVHSLKDLPTTPHEGTTII-VPERENPQDALCSRHGESLAHLPHGALV 120

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD---------NGEYDAIILAVAGLKR 176
           GT S RR  QL   RPDL I  +RGNV TRL+++            + DA++LA AGL+R
Sbjct: 121 GTGSPRRAAQLLVARPDLRIVDIRGNVDTRLARVGLSTADKPHIRNDLDAVVLAAAGLRR 180

Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSR----TRELLAALNHHETALRVTAER 232
           LG    I   LPP   LPA GQGA+ IE R D +         +  L+H  TA  V AER
Sbjct: 181 LGRAHVISELLPPTSMLPAPGQGALAIEVRHDMADHHPSILAGIRTLHHQPTAYAVAAER 240

Query: 233 AMNTRLEGGCQVPIGSYAEL-----------IDGEIWLRALVGAPDGSQII--------- 272
           A+   LE GC  P+G+ A +           +D  +   A    P  +  I         
Sbjct: 241 AVLRHLEAGCAAPVGALATMHNTTLTLTATALDPRLTPTAHTPTPSTTTDINAAPTPMTA 300

Query: 273 -----------RGERRGAPQDAEQMGISLAEELLNNGAREILAE 305
                            +  DA + GI+LA  LL +GA E L +
Sbjct: 301 PADARPPIRLTHTHTVTSENDATEAGITLATTLLTHGAAEFLRD 344


>UniRef50_D1JID7 Porphobilinogen deaminase n=1 Tax=uncultured archaeon
           RepID=D1JID7_9ARCH
          Length = 290

 Score =  297 bits (761), Expect = 3e-79,   Method: Composition-based stats.
 Identities = 97/295 (32%), Positives = 153/295 (51%), Gaps = 11/295 (3%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           + + TR S LAL Q   V ++L     G+  E+  + + GDV+ D  L ++   G+FVK+
Sbjct: 1   MIVGTRGSNLALVQTKKVCERLSEL--GVECEIKTVQSLGDVMTDRGLYEMPTIGVFVKK 58

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           L++ LL+ + DIAVHSMKD+P E  + L    +  R+ P DA VS     LD +P G+++
Sbjct: 59  LDMMLLDAKIDIAVHSMKDMPSEREEELDTSAVLPRDSPYDALVSR--YRLDDMPEGAVI 116

Query: 126 GTSSLRRQCQLAER----RPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           GTSS+RR+ Q           + I+ +RGNV TR++K   GEYD++ILA AG +RL L+ 
Sbjct: 117 GTSSVRRRYQFLNYVGERGVKVTIKDIRGNVDTRIAKFRRGEYDSVILAEAGFERLKLDI 176

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
                L  +  +P+  QG + +  R       E+L  ++  ET +    E  +   + GG
Sbjct: 177 EY-ERLDRDPFVPSPRQGIIAVVARRGSKE-SEILKQIDDSETRIEAEVEEEVLKVIGGG 234

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
           C +P+G +A    G + L   V A D    +     G     E+    LA++  +
Sbjct: 235 CSLPVGVHATAKGGSVELAVYVAASDVRYKLEKVVLGKDYYMEET-RELAQKFKS 288


>UniRef50_C4JRY9 Porphobilinogen deaminase n=1 Tax=Uncinocarpus reesii 1704
           RepID=C4JRY9_UNCRE
          Length = 287

 Score =  296 bits (758), Expect = 8e-79,   Method: Composition-based stats.
 Identities = 107/318 (33%), Positives = 154/318 (48%), Gaps = 58/318 (18%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
               I TR+SPLAL Q   V+  L  ++P                               
Sbjct: 7   KTYTIGTRKSPLALVQTDLVRRALQTAYPN------------------------------ 36

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLDALP 120
                       D+ VH    VP + P    L  +  RE+PRD  V        +L  LP
Sbjct: 37  -----------CDLKVHG--HVPTQIPDACVLGAMMPRENPRDVLVIKKGLPWMTLAELP 83

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGLKRLG 178
           AGS+VGTSS+RR  QLA   P L+++ +RGN+ TRL+KLD  +G +  +I+A AGL R G
Sbjct: 84  AGSVVGTSSVRRTAQLARHYPHLVVQDIRGNIDTRLAKLDAEDGPFTCLIMAAAGLLRTG 143

Query: 179 LESRIRAALPPE--ISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236
            E+R+   L  +    L AVGQGA+GIE R DD   ++++  +    T     AER +  
Sbjct: 144 HENRVTQYLDSKNGKMLHAVGQGALGIEVRTDDEVMKDMVNKIGDMPTTYACMAERNLLR 203

Query: 237 RLEGGCQVPIGSYAELIDGE-----IWLRALVGAPDGSQIIRGERRGA---PQDAEQMGI 288
            +EGGC  P+G   E I  +     + LRA+V + DG + +  E+ G     ++AE  G 
Sbjct: 204 TVEGGCSAPLGVETEWIQDDNGKSLLRLRAIVVSVDGKEAVELEKDGDVESIEEAEAFGK 263

Query: 289 SLAEELLNNGAREILAEV 306
            +A EL++ GA +IL E+
Sbjct: 264 QVALELIDKGAGKILEEI 281


>UniRef50_A9HK97 Porphobilinogen deaminase n=12 Tax=Acetobacteraceae
           RepID=A9HK97_GLUDA
          Length = 367

 Score =  295 bits (757), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 132/312 (42%), Positives = 166/312 (53%), Gaps = 21/312 (6%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLV----VELVPMVTRGDVILDTPLAKVGGKG 60
            LR+ TR SPLAL Q       L    P L      +   + T GD + +  LA++GGKG
Sbjct: 46  PLRVGTRASPLALVQTRAFLTMLTRFCPVLRDMGAFQEHQINTTGDQVQNRRLAEIGGKG 105

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD------ 114
           LF KE+  AL + R D AVHS+KD+    P GL L     RED RDA +           
Sbjct: 106 LFAKEIHDALSDGRIDFAVHSLKDLETTLPPGLVLACTLRREDARDALILGPGAGGRHDA 165

Query: 115 -----SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIIL 169
                   ALP  ++VG +S+RRQ Q+   RPDL    LRGNV TRL KL   + DA +L
Sbjct: 166 ADAADPYAALPRNALVGCASVRRQAQMLHVRPDLRFGLLRGNVQTRLDKLAARQCDATLL 225

Query: 170 AVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVT 229
           A+AGL+RLG+E R    L PEI +PA GQG VG+  R  D   RELLAA+  +E     T
Sbjct: 226 ALAGLRRLGMEDRADIVLDPEIMVPAAGQGIVGVTVRESDVELRELLAAIEDYEARAVAT 285

Query: 230 AERAMNTRLEGGCQVPIGSYAELIDG------EIWLRALVGAPDGSQIIRGERRGAPQDA 283
           AERA+   L+G C+ PIG YA L+ G       + L  LV   DGS ++R    G   DA
Sbjct: 286 AERALLAELDGSCRTPIGGYARLVPGLAGAEASLRLTGLVAREDGSFLLRRTVTGLRADA 345

Query: 284 EQMGISLAEELL 295
           E+MG  L   L 
Sbjct: 346 EEMGRELGRSLR 357


>UniRef50_B5JN62 Porphobilinogen deaminase n=1 Tax=Verrucomicrobiae bacterium DG1235
           RepID=B5JN62_9BACT
          Length = 291

 Score =  295 bits (757), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 112/294 (38%), Positives = 143/294 (48%), Gaps = 16/294 (5%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
               IATR+SPLA+ Q H  K+      P  V  +  MVT GD   +  L K GGKGLF 
Sbjct: 6   REYVIATRKSPLAMAQTHLAKELFQRGMPDAVFRIEKMVTTGDKRQEWSLEKQGGKGLFT 65

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KELE ALLE RAD AVHS KD+P E P+GL L     R+   D  +  +      L    
Sbjct: 66  KELEDALLEGRADFAVHSAKDLPSEMPKGLALAGFLPRQTCEDVLILRDGVESPKL---- 121

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG---LE 180
            + T S RR+ QL    P      +RGNV TRL+K+  G+ DA +LA AGL RLG    E
Sbjct: 122 -IATGSPRRRIQLRYLFPKAEFTEIRGNVDTRLTKIARGDADATVLASAGLNRLGIESWE 180

Query: 181 SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEG 240
                 L  +  +PAVGQ AV I+CR +D  T     A    ETA+ V  ER+    L G
Sbjct: 181 GVTFRKLTLDECVPAVGQAAVAIQCREEDVDT---FRAHLDEETAIAVNLERSFLEELGG 237

Query: 241 GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
           GCQV        + G + +        G ++    +       EQ+   L E+L
Sbjct: 238 GCQVAFAV--NYVGGRLRI---YHKQCGKEVRDLPQEYVATHYEQIAAKLIEQL 286


>UniRef50_Q2FTK7 Hydroxymethylbilane synthase n=3 Tax=Methanomicrobiales
           RepID=Q2FTK7_METHJ
          Length = 295

 Score =  293 bits (752), Expect = 4e-78,   Method: Composition-based stats.
 Identities = 111/306 (36%), Positives = 163/306 (53%), Gaps = 19/306 (6%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            LR+ TR S LA  QA  V   L     G+  ELV + T GD     PL ++GG+G+FV+
Sbjct: 2   PLRVGTRASELAKAQAVKVCTMLEDL--GVDTELVFISTAGDEQTGVPLHEIGGQGVFVR 59

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
            L+ AL++N+ D+AVHSMKD+P E P GL    I  R+ P D  V+++      L   + 
Sbjct: 60  ALDDALVQNKIDLAVHSMKDIPAERPYGLVTSAILARDSPCDYIVTDH-----ELDEITT 114

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GTSS RR  Q     P   IR LRGNV TRLSKL +GEYDAI+LA AGL+RL +     
Sbjct: 115 LGTSSTRRTAQCRRNLPWADIRPLRGNVNTRLSKLQSGEYDAIMLAKAGLERLSMTLDGY 174

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L P + +P+  QG + +  R  D    ++++ ++  +T +    ER +   + GGC  
Sbjct: 175 Q-LDPRVHVPSPNQGTIAVVSRT-DPDVTDIISKIDDPKTRMDTLLERRVMEMIGGGCFT 232

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGER-RGAPQDAEQMGISLAEELLNNGAREIL 303
           P+G Y +       + A V + +G +  R ER      DA++ G+ + E      A +++
Sbjct: 233 PLGIYCKDR----LMIAEVLSLEGDRHFRLERLVSDIDDADRFGLEVRER-----AGDLI 283

Query: 304 AEVYNG 309
            E Y  
Sbjct: 284 REAYER 289


>UniRef50_C3MZR8 Probable porphobilinogen deaminase n=11 Tax=Sulfolobus
           RepID=HEM3_SULIA
          Length = 293

 Score =  293 bits (751), Expect = 5e-78,   Method: Composition-based stats.
 Identities = 97/293 (33%), Positives = 147/293 (50%), Gaps = 9/293 (3%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            +RIA R S L+  Q   + +KL     G+  E++ + T+ D+    PL+K+G KG+F K
Sbjct: 2   KIRIAARGSKLSRIQVDMLGEKLKKI--GIEYEIIDIKTKADLFSTEPLSKLG-KGVFEK 58

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           E+  A+LE +ADIAVHSMKD+  E    L +  + ER+ P D  ++    +LD L +   
Sbjct: 59  EVNEAVLEGKADIAVHSMKDILSEINPSLEIFAVLERDPPYDILIAEK--NLDKLDSNIT 116

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GTSS+RR+  L   +P++  + +RGNV TR+ K  + EY  +ILA A LKRL +     
Sbjct: 117 IGTSSIRRKNFLKYIKPEINTKDIRGNVDTRIRKYLSKEYQGLILAEASLKRLNMTMNYH 176

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
                +   P   QG +    R  D + +E+   +NH +T     AERA+ + + GGC  
Sbjct: 177 RLNVYD-FTPEANQGIIVALGRKKDEKIKEIFKEINHKDTLDEALAERAVISLVGGGCHS 235

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           PIG   +    E     +    DG + I       P D   +G  L   L   
Sbjct: 236 PIGVLFKKEGKE--FYGIASYSDGKKKITVSIS-KPGDPYTIGSELGLLLKKE 285


>UniRef50_D2RNT2 Porphobilinogen deaminase n=1 Tax=Acidaminococcus fermentans DSM
           20731 RepID=D2RNT2_ACIFE
          Length = 288

 Score =  292 bits (749), Expect = 8e-78,   Method: Composition-based stats.
 Identities = 117/297 (39%), Positives = 163/297 (54%), Gaps = 14/297 (4%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             L +ATR S LAL Q H V   L  +  G+  E+  + T GD      L K+GG+G+FV
Sbjct: 2   KKLIVATRGSRLALAQTHIVCRLLEEA--GVETEIRTITTAGDRDRIHALVKIGGRGIFV 59

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           +E+E  LL   ADIAVHS KD+P +   GL +     + DPRDA V      L+   AGS
Sbjct: 60  REIERELLSGEADIAVHSAKDLPYQLASGLVIAGTPSQADPRDALVLLKERKLE---AGS 116

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           +VGT S RR  +++   P+L+ R +RGNV TRL KL+ GEYDAI+LA+AG++RL L+   
Sbjct: 117 VVGTGSPRRIREISRVLPELVFRDIRGNVTTRLHKLERGEYDAIVLAMAGIQRLALDMEQ 176

Query: 184 RAA--LPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
                L  E  +PA  QG +G+ECR  D     LL  ++  ET  R   ER + T ++  
Sbjct: 177 FQIRPLSTEQVIPAGCQGIIGVECRQKDRELVRLLQQISDPETWRRFQWERQLFTSMKVD 236

Query: 242 CQVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
           C  P+G +   L  G + L A+V   DG +  R    G  ++ + +  SL EEL + 
Sbjct: 237 CSRPVGIHCRLLKSGRMELLAMV---DGKRARRL---GMEKEGKALCASLKEELYDR 287


>UniRef50_C0W553 Porphobilinogen deaminase n=2 Tax=Actinomycetales
           RepID=C0W553_9ACTO
          Length = 402

 Score =  291 bits (747), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 129/387 (33%), Positives = 176/387 (45%), Gaps = 81/387 (20%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASH----PGLVVELVPMVTRGDVILDTPLAKVGGK 59
           + +R+ TR S LAL Q+  V   L  +       L VELVP+ TRGDV   T L+++GG 
Sbjct: 2   STVRLGTRGSALALTQSGLVARMLEQAAALAGQELHVELVPVRTRGDVD-PTALSQLGGV 60

Query: 60  GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD-SLDA 118
           G+F   L  ALL    D+AVHS KD+P     GL +  +  REDPRD   +      L  
Sbjct: 61  GVFATALREALLAGECDLAVHSYKDLPTAAVPGLRIAAVPAREDPRDVLCTRAATLGLHD 120

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL--------------DNGEY 164
           LPAG+ VGT S RR  QL  +RPDL I  +RGNV TRL+++                 + 
Sbjct: 121 LPAGARVGTGSPRRSAQLLAQRPDLTIVPIRGNVPTRLARVVGSVVSADGPMGATAEPDL 180

Query: 165 DAIILAVAGLKRLGLESRIRAALP---------------------------PEISLPAVG 197
           DA ILA++G++RLGLE      L                                LPA  
Sbjct: 181 DAAILALSGMRRLGLEDYASQPLAARCGARSQVEVQGIPDGGSAAGSPATTEPWMLPAAA 240

Query: 198 QGAVGIECRLDDSRTREL------LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAE 251
           QGA+ +E R  D  + EL      LA ++   T     AER++   L  GC  P+G+ A 
Sbjct: 241 QGALAVETR--DRVSCELPVLTVALALVDDPVTRACADAERSLMRCLAAGCAAPVGALAR 298

Query: 252 LID--------------------------GEIWLRALVGAPDGSQIIRGERRGAPQDAEQ 285
            +D                            I L ALV + DG+Q+ R    G  ++AE 
Sbjct: 299 PLDVAGEPAAGRDLPTEPGTALEPGPDQAPAICLEALVASLDGTQLRRASATGTLEEAED 358

Query: 286 MGISLAEELLNNGAREILAEVYNGDAP 312
           +G  +AE LL +GA +I     +  +P
Sbjct: 359 LGRCVAERLLADGAAQITDLQASKGSP 385


>UniRef50_Q4PFH9 Putative uncharacterized protein n=1 Tax=Ustilago maydis
           RepID=Q4PFH9_USTMA
          Length = 770

 Score =  291 bits (745), Expect = 3e-77,   Method: Composition-based stats.
 Identities = 115/296 (38%), Positives = 153/296 (51%), Gaps = 39/296 (13%)

Query: 34  LVVELVPMVTRGDVILDTPLAKVGGKG--LFVKELEVALLENRADIAVHSMKDVPVEFPQ 91
               +  M T GD  L +PL  +GG+G  ++ KELEVAL +   D  VH +KDVP   PQ
Sbjct: 249 HAFPITSMSTAGDQNLRSPLYVIGGEGKAIWTKELEVALEQGAVDAIVHCLKDVPTALPQ 308

Query: 92  GLGLVTICEREDPRDAFVSNNYDS---LDALPAGSIVGTSSLRRQCQLAERRPDLIIRSL 148
           GL L  + EREDPRDA V         LD LP GS++GTSS+RR  QL  R P L+   +
Sbjct: 309 GLELAAVLEREDPRDALVVKAGLPYKVLDELPVGSVIGTSSVRRVAQLRRRYPHLVFSDV 368

Query: 149 RGNVGTRLSKLD--NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECR 206
           RGN+ TRL+KLD  NG Y A+ILA AGL RL + +RI A L   + L +VGQG++ IE R
Sbjct: 369 RGNINTRLAKLDAPNGPYTALILAAAGLVRLNMHARITAFLSSPVLLHSVGQGSLAIEVR 428

Query: 207 L----------DDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGE 256
                       D+R REL+ ++       R  AER++   LEGGC +P+G      D  
Sbjct: 429 TPPEGADPTTNRDARIRELIRSIGDWRATFRAEAERSLLKELEGGCSIPVGVETRFDD-- 486

Query: 257 IWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYNGDAP 312
                             +  G   +A    I+L ++ +  G     AE+ NG  P
Sbjct: 487 ----------------HDQVEGQRSEA----IALVDDFVTQGNAGAKAELPNGGMP 522



 Score = 48.6 bits (115), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 28/89 (31%), Positives = 39/89 (43%), Gaps = 8/89 (8%)

Query: 222 HETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERR---G 278
             T  +  AER ++T       +   S        + L A+V + DGSQ  R        
Sbjct: 573 PSTNAQTIAERIVSTSY----SIVDRSTPAPEGRTLHLDAIVVSLDGSQESRYSASKHCT 628

Query: 279 APQDAEQMGISLAEELL-NNGAREILAEV 306
             +DA ++GI +A EL    GAR IL EV
Sbjct: 629 TVKDARELGIHVAHELAHKKGARAILEEV 657


>UniRef50_C8WDJ7 Porphobilinogen deaminase n=3 Tax=Zymomonas mobilis
           RepID=C8WDJ7_ZYMMN
          Length = 308

 Score =  285 bits (730), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 116/292 (39%), Positives = 162/292 (55%), Gaps = 7/292 (2%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHP--GLVVELVPMVTRGDVILDTPLAKVGGK 59
           +    R+ +R SPLAL QA  V   L A+H      V +VP+ T GD      LA +GGK
Sbjct: 1   MQLPFRLGSRGSPLALIQARSVASALCAAHSWSEDAVVIVPIRTSGDKNRHQALADIGGK 60

Query: 60  GLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDAL 119
            L+ KEL++AL   + D AVHSMKDV    P  + +  +  RED  D  +     SL+ L
Sbjct: 61  ALWTKELDIALTTGQIDAAVHSMKDVETFRPSHISIAAMLPREDVHDRLIG--IPSLEVL 118

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL 179
           P    VGT+S RR  Q+   RPD+ I+ LRGN+ TRL KL N ++DA +LA AGL RLG 
Sbjct: 119 PYSGCVGTASPRRAAQIRRIRPDIEIKLLRGNIDTRLEKLANKQFDATLLAAAGLIRLGR 178

Query: 180 ESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
              +   +P +  LPA GQGA+GIE    DS   E ++ ++H+ T L V +ER +  RL 
Sbjct: 179 ND-VGYDVPLDQMLPAAGQGAIGIEALA-DSAAWEKVSIIDHYPTHLAVQSERQLLLRLN 236

Query: 240 GGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGA-PQDAEQMGISL 290
             C  PI  +AE+++  I LRA +   +G      ++  + P DA ++G  L
Sbjct: 237 ADCHSPIAVFAEILEKNIRLRACLYTENGKFSASIDKEISQPSDAFEVGSLL 288


>UniRef50_Q97B26 Probable porphobilinogen deaminase n=2 Tax=Thermoplasma
           RepID=HEM3_THEVO
          Length = 297

 Score =  284 bits (728), Expect = 3e-75,   Method: Composition-based stats.
 Identities = 86/267 (32%), Positives = 136/267 (50%), Gaps = 6/267 (2%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            ++I TR S LA+ QA+ V   L A   G+  E+V   + GD+    P+  +G  G+FV+
Sbjct: 2   KIKIGTRPSNLAVAQANMVASSLEAI--GIDTEIVKHRSAGDIDTKNPIYSIGKTGVFVQ 59

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           +L   +L    D+AVHS KD+P E    L +    +R    DA VS     L +LP  + 
Sbjct: 60  DLNNMILRGEIDVAVHSAKDIPSEIENRLTIAATLKRGSFNDALVSK--YDLRSLPISAK 117

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGTSS+RR  QL   R DL   ++RGN+ TR++K+     DAI++A A ++RLGL     
Sbjct: 118 VGTSSIRRIFQLKYARQDLKFENIRGNIETRIAKMSELGLDAIVMAEAAIQRLGLNVEYS 177

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L     +PA  QG + +  + + +  R++L  +N   T   +  ER++  +L+ GC  
Sbjct: 178 K-LDENKFVPAPNQGIIAVVSKKEGT-VRKILEEINDENTFEEMQIERSVVQQLKLGCST 235

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQI 271
           P+G  +        + A   +  G  +
Sbjct: 236 PVGILSRPSGKGHKIIAQFFSMQGDDV 262


>UniRef50_A2BFN7 Hydroxymethylbilane synthase (Fragment) n=6 Tax=Coelomata
           RepID=A2BFN7_DANRE
          Length = 247

 Score =  283 bits (726), Expect = 4e-75,   Method: Composition-based stats.
 Identities = 112/229 (48%), Positives = 144/229 (62%), Gaps = 4/229 (1%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62
             V+R+ TR+S LA  Q   V   L   +P + +E+V M T GD ILDT L+K+G K LF
Sbjct: 19  SRVIRMGTRKSQLARIQTDSVAGTLKQLYPDVHLEIVAMSTIGDKILDTALSKIGEKSLF 78

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDAL 119
            KELE AL  N  DI VHS+KD+P   P G  +  I ERE+P DA V +      +LD+L
Sbjct: 79  TKELENALERNEVDIVVHSLKDLPTSLPPGFTIGAILERENPHDAVVLHPKNAGLTLDSL 138

Query: 120 PAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLG 178
           P  S++GTSSLRR  QL +R P L   ++RGN+ TRL KLD   +Y AIILA AGLKR+G
Sbjct: 139 PEKSVIGTSSLRRAAQLKKRFPQLEFENIRGNLNTRLKKLDEKDDYAAIILAAAGLKRMG 198

Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALR 227
            ESRI   L PE  + AVGQGA+ +E R  D    E+++ L+H +T LR
Sbjct: 199 WESRISQVLGPEDCMYAVGQGALAVEVRAQDKDILEMVSVLHHPDTVLR 247


>UniRef50_C1XV35 Porphobilinogen deaminase n=2 Tax=Meiothermus RepID=C1XV35_9DEIN
          Length = 304

 Score =  283 bits (725), Expect = 5e-75,   Method: Composition-based stats.
 Identities = 114/270 (42%), Positives = 159/270 (58%), Gaps = 11/270 (4%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   +RIATR S LA WQA +V  +L     G+   LV + T+GD       +++ G+G 
Sbjct: 1   MSR-VRIATRGSRLARWQAEWVAAQLQDQ--GIASTLVIVETQGDRER-VAFSQMQGQGF 56

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP- 120
           F K ++ A+ E RAD+AVHS+KD+P     GL L  I  REDPR+A +          P 
Sbjct: 57  FTKAVQDAVREGRADLAVHSLKDLPSAPTPGLVLAAIPIREDPREALLVLPSAWDAQAPA 116

Query: 121 ----AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKR 176
                G+ VG+S++RRQ QLA+ RPDL +  LRGNV TR+ KL +G Y+AI+LA AGLKR
Sbjct: 117 LPLAPGARVGSSAVRRQAQLAQLRPDLKLLELRGNVPTRVEKLQSGGYEAILLAWAGLKR 176

Query: 177 LGLE--SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234
           LGL+        L P   +PA GQGA+ +ECR +D++ R +L  L+     L V  ER +
Sbjct: 177 LGLDLGGLAVRLLEPREFVPAPGQGALALECREEDTQLRGVLQGLDDPTARLTVGIERGL 236

Query: 235 NTRLEGGCQVPIGSYAELIDGEIWLRALVG 264
             RL+GGCQ+ +G+ A+ + G   L A  G
Sbjct: 237 MARLQGGCQLALGASAQRVQGGWQLLAWYG 266


>UniRef50_C5C5B3 Porphobilinogen deaminase n=6 Tax=Actinomycetales
           RepID=C5C5B3_BEUC1
          Length = 334

 Score =  282 bits (722), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 120/294 (40%), Positives = 155/294 (52%), Gaps = 25/294 (8%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASH-----PGLVVELVPMVTRGDVILDTPLAKV 56
               LR+ TR S LA  Q+ +  + + A         + VELV + T GD +L   LA +
Sbjct: 18  STRTLRVGTRASALATTQSEWAGEAIAARVAAATGSDVEVELVRVTTTGD-VLTGSLASM 76

Query: 57  GGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSL 116
           GG G+FV  L  ALL+ R D+AVHS+KD+P     GL L  + +REDPRD   +     L
Sbjct: 77  GGTGVFVTALREALLDGRCDVAVHSLKDLPTAAAPGLVLGAVPQREDPRDVLCARAGAGL 136

Query: 117 DALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD--NGEYDAIILAVAGL 174
             LPAG  VGT S RR  QL   RPDL I  +RGNV TRLS++    G+ DA++LA AGL
Sbjct: 137 ADLPAGGRVGTGSPRRAAQLRRARPDLEIVDIRGNVDTRLSRISPGKGDLDAVVLARAGL 196

Query: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECR-LDDSRTRELLAALNHHETALRVTAERA 233
            RLG    +  AL   + +PA GQGA+ +E            L A +   T L VTAERA
Sbjct: 197 ARLGRLDAVTEALDAGVMVPAPGQGALAVEAVDAAPDWLLAGLRAFDDAPTRLAVTAERA 256

Query: 234 MNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMG 287
           M  RLE GC  P+G+ A L   ++ LR  VG                +DAE +G
Sbjct: 257 MLARLEVGCSAPVGALATLAGSQLLLRTSVG----------------EDAEDLG 294


>UniRef50_Q8I5V3 Porphobilinogen deaminase n=6 Tax=Plasmodium RepID=Q8I5V3_PLAF7
          Length = 435

 Score =  281 bits (721), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 95/367 (25%), Positives = 164/367 (44%), Gaps = 61/367 (16%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHP----GLVVELVPMVTRGDVILD-TPLAKVG 57
            + + I TR SPLAL Q+  V+ K+M+        + V    + T GD ILD   +   G
Sbjct: 59  KDEIIIGTRDSPLALKQSEKVRKKIMSYFKKMNKNINVTFKYIKTTGDNILDSKSVGLYG 118

Query: 58  GKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLD 117
           GKG+F KEL+  L+    D+ VHS+KDVP+  P  + L    +R+   DAF+S  Y S++
Sbjct: 119 GKGIFTKELDEQLINGNVDLCVHSLKDVPILLPNNIELSCFLKRDTINDAFLSIKYKSIN 178

Query: 118 ALPAGS------------------------IVGTSSLRRQCQLAERRPDLIIRSLRGNVG 153
            +                             +GTSSLRR+ Q+  R  ++ + ++RGN+ 
Sbjct: 179 DMNTVKSVSKTEDIHHINKKDSDHNNDTLCTIGTSSLRRRSQIKNRYKNIYVNNIRGNIN 238

Query: 154 TRLSKLDNGEYDAIILAVAGLKRL--------------------------------GLES 181
           TR+ KL NGE DA+I+A+ G++RL                                 L  
Sbjct: 239 TRIEKLYNGEVDALIIAMCGIERLIKKANLKHLLKNKEQKNICQPFLLKCNNKKCIDLCH 298

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
                L   +  PA+GQG + +     +     LL  +N+ ++ +    ER+    ++G 
Sbjct: 299 VNIQKLNKNLIYPALGQGIIAVTSHKKNYFISSLLKNINNKKSEMMAQIERSFLYHIDGN 358

Query: 242 CQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGARE 301
           C +PIG Y  + + +I+L  ++    G    +  ++    + +++G + A ++      E
Sbjct: 359 CMMPIGGYTNMRNEDIYLHVIINDIHGYNKYQVTQKDTLYNYKEIGPNAAIKMKEIIGTE 418

Query: 302 ILAEVYN 308
              ++  
Sbjct: 419 QFNKIKA 425


>UniRef50_B4D5X7 Porphobilinogen deaminase n=1 Tax=Chthoniobacter flavus Ellin428
           RepID=B4D5X7_9BACT
          Length = 307

 Score =  281 bits (720), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 109/277 (39%), Positives = 149/277 (53%), Gaps = 14/277 (5%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPL---AKVGGKG 60
             + + TR S LA+ Q       L A+ P + +E    VTRGD  LD  L    + GGKG
Sbjct: 2   KSIILGTRASALAVAQVELTTKALAAAFPAMQIERREFVTRGDKKLDLSLLRANEAGGKG 61

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
           LF KELE ALL    D+AVHS+KD+P   P GL +  + ER    D  ++    +L  LP
Sbjct: 62  LFTKELEDALLNGSIDVAVHSLKDLPGHNPPGLDITAVLERAPTADVLITKQPQTLLDLP 121

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGL 179
            G ++GTSS+RR  QL  RRPD+ +   RGNV TRL KL    +   IILA AGL+RLG 
Sbjct: 122 QGVLLGTSSVRRARQLQWRRPDVRVEEWRGNVQTRLRKLAERDDVTGIILAQAGLERLGH 181

Query: 180 ESRIRAALPP----------EISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVT 229
           +                   E  LPA+GQGA+ ++ R D +    +L  ++H ET L + 
Sbjct: 182 DLSAGRLETEHGKFYVTSLAEDLLPAIGQGAIALQSRADRAEVAAVLQKIDHRETHLAIR 241

Query: 230 AERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAP 266
           AER +   L G C +P+G   +L+ G I +RA++  P
Sbjct: 242 AERELQRLLAGDCALPVGVRTKLLPGGIAMRAILFGP 278


>UniRef50_B0WMK9 Porphobilinogen deaminase n=1 Tax=Culex quinquefasciatus
           RepID=B0WMK9_CULQU
          Length = 474

 Score =  281 bits (719), Expect = 3e-74,   Method: Composition-based stats.
 Identities = 96/243 (39%), Positives = 133/243 (54%), Gaps = 29/243 (11%)

Query: 13  SPLALWQAHYVKDKLMASHPGLVVELV------------------------PMVTRGDVI 48
           S LAL Q  YV   L   +P +V E+                          M T GD +
Sbjct: 167 SKLALIQTKYVISCLQKLNPDVVYEIRKYFQHVHLCWHVPSYLLAFFLSPDTMTTVGDRV 226

Query: 49  LDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAF 108
           L+  L K+G K LF K+LE AL     D  VHS+KD+P   P G+ +  + ER+DPRDA 
Sbjct: 227 LNKSLPKIGEKSLFTKDLEDALRTGGVDFVVHSLKDLPTALPLGMAIGAVLERDDPRDAL 286

Query: 109 V---SNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG--E 163
           V   ++   +L  LP GS+VGTSSLRR  QLA +  ++++  +RGN+ TRL+KLD    +
Sbjct: 287 VLNEAHRGRTLSTLPKGSVVGTSSLRRSAQLARKYENVVVCDIRGNLNTRLAKLDADGSK 346

Query: 164 YDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHE 223
           +  IILA AGL R+G  +R+   + P   L AVGQGA+ +ECR +D    ++L+ L H E
Sbjct: 347 FAGIILAQAGLVRMGWNARVSQVIEPGEILYAVGQGALAVECRSNDEYILDMLSKLCHLE 406

Query: 224 TAL 226
           T  
Sbjct: 407 TQC 409


>UniRef50_Q93A65 Porphobilinogen deaminase n=1 Tax=uncultured bacterium
           RepID=Q93A65_9BACT
          Length = 299

 Score =  280 bits (717), Expect = 4e-74,   Method: Composition-based stats.
 Identities = 120/296 (40%), Positives = 168/296 (56%), Gaps = 19/296 (6%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +R+ATR S LALWQA +V  +L+    G  VELV + T+GD     P A++ G+G F K 
Sbjct: 4   VRLATRGSRLALWQAEWVAKQLVQQ--GAEVELVVVETQGDR-EKRPFAQMQGQGFFTKA 60

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSN-----NYDSLDALP 120
           ++ A+LE RAD AVHS KD+P   P GL +  +  REDPR+  +              L 
Sbjct: 61  VQEAVLEGRADFAVHSYKDLPSARPAGLEIAAVPPREDPRELLLVRLQAVDQVAPGLPLR 120

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLE 180
           AG+ VG+S+ RRQ QLA  RPDL +  LRGNV TR+ KL  GEYDA++LA AG++RLGL+
Sbjct: 121 AGARVGSSAARRQAQLAHLRPDLSLLELRGNVLTRVEKLRQGEYDAVLLAYAGVRRLGLD 180

Query: 181 --SRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRL 238
                   LPP + +PA  QGA+ +ECR DD R R LL  L+     +R      +  RL
Sbjct: 181 LSPFHWQVLPPTLLVPAPAQGALALECRQDDKRLRPLLEPLDDPSAGVRCGGA-GLMARL 239

Query: 239 EGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
            GGCQ+ +G+ A+     + L A        +    + RG+  D E +  ++ +E+
Sbjct: 240 AGGCQLALGALAQETPEGLQLLAWY------RGRSYQARGS--DPEAVAEAVFKEI 287


>UniRef50_Q9Y9J0 Probable porphobilinogen deaminase n=1 Tax=Aeropyrum pernix
           RepID=HEM3_AERPE
          Length = 307

 Score =  280 bits (717), Expect = 4e-74,   Method: Composition-based stats.
 Identities = 106/294 (36%), Positives = 158/294 (53%), Gaps = 8/294 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVV--ELVPMVTRGDVILDTPLAKVGGKGLFV 63
           +R+A R S L+L Q     ++L + + G+ +  E+V + + GDV  D PL  +G  G+F 
Sbjct: 3   VRVAARGSRLSLLQVEQALEEL-SRYAGVSMHWEVVRVKSAGDVWSDRPLESIGVVGVFT 61

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQG-LGLVTICEREDPRDAFVSNNYD-SLDALPA 121
           +E++ A+    ADIAVHS+KD+P     G L +V I  R   RDA +S      ++ L  
Sbjct: 62  REVDRAVASGAADIAVHSLKDMPTSGYGGPLKIVYIASRPSARDALISRQGPGRVEDLEP 121

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLES 181
           GS +GTSS RR+       P + + +LRGN+ TRL KL  G YDAII + AGL RLG++ 
Sbjct: 122 GSTLGTSSARRRALSLHYNPRIRVENLRGNLDTRLRKLREGLYDAIIASEAGLIRLGVDV 181

Query: 182 RIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGG 241
                L P    PA GQG V +  R+  S   ++L  L+         AER +      G
Sbjct: 182 EYT-PLDPSYFPPAPGQGFVAVVARVG-SNVEKMLRDLDKPPWWHVAWAERGVLEGARAG 239

Query: 242 CQVPIGSYAELID-GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
           C+ P+ +YAE +    + + A   +PDGS+       G  ++A ++G+SL EEL
Sbjct: 240 CRTPVAAYAEPLGRSMVRVTAAALSPDGSRAYWARAEGRIEEARRIGVSLGEEL 293


>UniRef50_Q0RS16 Porphobilinogen deaminase 1 (PBG 1) (Hydroxymethylbilane synthase
           1) (HMBS 1) (Pre-uroporphyrinogen synthase 1) n=2
           Tax=Frankia RepID=Q0RS16_FRAAA
          Length = 402

 Score =  278 bits (713), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 121/366 (33%), Positives = 168/366 (45%), Gaps = 77/366 (21%)

Query: 13  SPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLE 72
           S LAL Q+  +  +L     G  V+LVP+VT GD      ++++GG G+FV  L  ALL 
Sbjct: 36  SALALTQSGMIAAQLRERV-GCAVDLVPIVTAGDR-SPAEISQIGGTGVFVSALRDALLA 93

Query: 73  NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRR 132
              D+AVHS+KD+P   P GL L  +  RED RD  VS +   L AL  G+ V T + RR
Sbjct: 94  GEIDLAVHSLKDLPTATPPGLVLAAVPTREDTRDVLVSPSGRGLAALGPGARVATGAPRR 153

Query: 133 QCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEIS 192
             QL        + ++RGNV TRL K  +GE DA++LA AGL RL     +   L PE+ 
Sbjct: 154 AAQLRALGLGFDVVAIRGNVDTRLKKAIDGEVDAVVLAYAGLARLDRLDAVTEILDPEVM 213

Query: 193 LPAVGQGAVGIE------------------------------------------------ 204
           LPA GQGA+ +E                                                
Sbjct: 214 LPAPGQGALAVECAAEAGLRLAGPARALVAAGAGDHADGDRPGAEAGRDGRGRGPDVGRN 273

Query: 205 ---CRLD-----DSRTRELLAA-LNHHETALRVTAERAMNTRLEGGCQVPIGSYAELID- 254
               R D     D    ELL   L+   +++ + AERA    +E GC  P+G+ A     
Sbjct: 274 SGQTRSDHGQPLDGGLAELLRFVLDDASSSVAIRAERAFLAGIEAGCTAPVGALAVAEPA 333

Query: 255 -----------------GEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
                            G + LRA+V APDGS ++R +  G+  D E +G  LA++LL+ 
Sbjct: 334 PAAAVGTVAPAGDASPAGRLRLRAVVAAPDGSTVLRRDVTGSAVDPEALGQRLADDLLSA 393

Query: 298 GAREIL 303
           GA  ++
Sbjct: 394 GAHSLM 399


>UniRef50_Q1GP41 Porphobilinogen deaminase n=7 Tax=Sphingomonadales RepID=HEM3_SPHAL
          Length = 315

 Score =  274 bits (702), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 134/306 (43%), Positives = 169/306 (55%), Gaps = 10/306 (3%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGL--VVELVPMVTRGDVILDTPLAKVGGKG 60
           DN LRI TR SPLA+ QAH     L+A+H      +E+VPM   GD I D  LA+VGGK 
Sbjct: 8   DNPLRIGTRASPLAMAQAHMAAAALIAAHGLAMAALEIVPMTATGDRIQDRALAEVGGKA 67

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY---DSLD 117
           L+ +EL+ AL     D+AVHS+KDV         L  + ER DPRD  V         + 
Sbjct: 68  LWTRELDAALDAGTIDVAVHSLKDVETLRDARFFLGAMLERADPRDRLVVREGIAAQKIS 127

Query: 118 ALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRL 177
            LP G+ +GTSS RR  Q+   RPDL    LRGNV TRL+KL  GE DA +LA AGL+RL
Sbjct: 128 ELPHGARLGTSSPRRAAQVRRLRPDLDTVLLRGNVATRLAKLAAGEADATLLAAAGLERL 187

Query: 178 GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR 237
           G+   I A    E+ LPA  QGA+GIECR DD+ T  LLAA++H  T   V AERA+   
Sbjct: 188 GM-HDIGAVQGTELLLPAASQGAIGIECRADDAATIALLAAIDHAPTHRAVAAERALLAV 246

Query: 238 LEGGCQVPIGSYAELI-DGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLN 296
           L G C+ P+ +YAE   DG + L A + + DG+  + G              +L   LL 
Sbjct: 247 LGGDCRSPVAAYAEWQADGVLRLDAEIFSEDGADHVAGHVIVTDAGVVA---ALGHRLLA 303

Query: 297 NGAREI 302
                I
Sbjct: 304 EAPPSI 309


>UniRef50_Q83H95 Porphobilinogen deaminase n=2 Tax=Tropheryma whipplei
           RepID=Q83H95_TROW8
          Length = 321

 Score =  271 bits (693), Expect = 3e-71,   Method: Composition-based stats.
 Identities = 109/331 (32%), Positives = 154/331 (46%), Gaps = 42/331 (12%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            LRI TR S LA  Q   V+  +      L  + V + T      D         G FV 
Sbjct: 3   PLRIGTRSSLLATAQTAQVQKTMRDVFL-LDTQQVLIQTGSVRRRD---------GSFVA 52

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
            L  ALLE   D+AVHS+KD+P+   +G  +  +  REDP D   +    +L  LP+G+ 
Sbjct: 53  ALRTALLEGECDLAVHSLKDIPIAPHEGTLITAVLPREDPCDVLCARKDLTLTTLPSGAK 112

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           VGT+S RR+ Q+   RPDL + SLRGN+  RL  LD    DAI+L+ AGLKR+  E  I 
Sbjct: 113 VGTASARRRAQILNFRPDLDVVSLRGNIDKRLIHLDT--LDAIVLSAAGLKRIDREDAIT 170

Query: 185 AALPPEISLPAVGQGAVGIE-CRL--DDSRTRELLA-ALNHHETALRVTAERAMNTRLEG 240
            +        A GQG++ IE CR   DD + R  +   L++    +  TAER + + L+ 
Sbjct: 171 ESFDIHDWPTAAGQGSLAIEVCRAQLDDPQNRVAVTYRLDNPMARVTTTAERGVLSLLQA 230

Query: 241 GCQVPIGSYAEL--IDGEIWLRALVGAPDGSQIIRG--------------------ERRG 278
            C  PI  +A     D  + L A V + DG                              
Sbjct: 231 DCFSPIAVHAVYTANDKSLRLHAKVFSRDGKIFCESIRFARLVKQLTDTNQNHTKNSGSD 290

Query: 279 APQDAEQMGISLAE----ELLNNGAREILAE 305
              +A ++ ++LA+    ELL+  AREIL +
Sbjct: 291 DIGNALEVAMTLAKTVVDELLSKNAREILKQ 321


>UniRef50_UPI000038E213 porphobilinogen deaminase n=1 Tax=Ferroplasma acidarmanus fer1
           RepID=UPI000038E213
          Length = 285

 Score =  270 bits (690), Expect = 7e-71,   Method: Composition-based stats.
 Identities = 91/266 (34%), Positives = 139/266 (52%), Gaps = 8/266 (3%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            + I TR S LAL QA+ VKD L +   G  V +    + GD   + PL ++   G+FV 
Sbjct: 2   PVTIGTRNSKLALIQANSVKDALESR--GYEVNIKSYTSAGDSNKNIPLYRMSSTGVFVD 59

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           EL   +L+   D+AVHS KD+P    +GL +  +  R+D RD  +S     L+ + AGS+
Sbjct: 60  ELNERVLKGEIDLAVHSAKDIPSNIQKGLEITAVTGRDDFRDVLISR--TPLEEMTAGSV 117

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +GTSS+RR  Q     P++ +  +RGN+ TR+SK    +Y  II+A+A  KR+ L+    
Sbjct: 118 IGTSSMRRIRQAMTVNPEITVSDIRGNIDTRISKYTEKKYTGIIIAMAAYKRMKLDIE-H 176

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             L  E  LPA  QG + I  + +   +  +   +N  ET   +  ER + T L  GC +
Sbjct: 177 FILSEEQFLPAPNQGIIAIVGKSNSPASI-ISGEINDRETYRDMKNERFIATSLNLGCSM 235

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQ 270
           P+G  ++  DG+I  R      D  +
Sbjct: 236 PVGILSK--DGKIKTRFYSLDSDEHR 259


>UniRef50_A9V9E0 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V9E0_MONBE
          Length = 643

 Score =  268 bits (685), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 99/206 (48%), Positives = 124/206 (60%), Gaps = 6/206 (2%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           +RI TR S LA+WQ  +V ++L  +HPG+   +VP+ T GD  L   L K    G+F   
Sbjct: 417 IRIGTRSSVLAMWQTRWVVERLTRAHPGVRFSVVPLSTVGDANLTLDLNKFSTTGIFTDA 476

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS----LDALPA 121
           L  ALL    DI VHS+KD+P     G  L  I  REDPRD  V ++  S    L  LPA
Sbjct: 477 LVRALLAQEVDILVHSLKDLPSTISPGTQLAAIGPREDPRDVVVFHHRHSEIKDLAQLPA 536

Query: 122 GSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN--GEYDAIILAVAGLKRLGL 179
           G++VGTSS RR+ QLA   P L    +RGNV TRL KLD+    YDA+ LA AGL RLGL
Sbjct: 537 GAVVGTSSTRRRAQLAAAYPQLRFAPVRGNVMTRLRKLDDPANGYDALCLAAAGLIRLGL 596

Query: 180 ESRIRAALPPEISLPAVGQGAVGIEC 205
           E+RI   LP  +S  A+GQGA+GI+ 
Sbjct: 597 EARIGQFLPLTVSRHAIGQGALGIQV 622


>UniRef50_UPI0001C31A39 porphobilinogen deaminase n=1 Tax=Conexibacter woesei DSM 14684
           RepID=UPI0001C31A39
          Length = 314

 Score =  262 bits (671), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 132/292 (45%), Positives = 169/292 (57%), Gaps = 13/292 (4%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
           +VLRI TR S LAL QA +V   L     G  VE++P+ T GD         +G K  +V
Sbjct: 2   SVLRIGTRASALALVQAEHVASLLRDG--GAQVEVIPITTSGDRGR-----LLGDKSRWV 54

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           KELE ALL +  D+AVHS KDVP E P G  L  +  R D RDA       SL+ LP G+
Sbjct: 55  KELEAALLADEVDVAVHSAKDVPAELPDGFVLAGVPARADARDALCG--AASLEQLPDGA 112

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
           +VGTSSLRR  +L   RPDL + +LRGNV TRL KL +G+  AI+LAVAGL+RL   + I
Sbjct: 113 VVGTSSLRRAAELRALRPDLGVVALRGNVDTRLRKLADGQAAAIVLAVAGLERLDRGAAI 172

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
            A L  +  +PA GQGA+ +E R DD R R   AA+   + A  + AERA+  RL   C 
Sbjct: 173 GAVL--DQLVPAPGQGALALETRADDDRARAAAAAITDADAAACLAAERALVRRLGATCH 230

Query: 244 VPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRGAPQ-DAEQMGISLAEE 293
            P+G++A    DG + LR+ VG PDGS  +R E   A   D E  G++    
Sbjct: 231 TPLGAHAVRTADGGLRLRSFVGLPDGSAWLRDELSAAAGIDPETFGVAAGTR 282


>UniRef50_Q04X38 Bifunctional porphobilinogen deaminase/uroporphyrinogen synthase
           n=4 Tax=Leptospira RepID=Q04X38_LEPBL
          Length = 542

 Score =  262 bits (670), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 89/279 (31%), Positives = 127/279 (45%), Gaps = 32/279 (11%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +  VL+IA+R+S LA  Q + V D L    P + +EL      GD+ L TPL K+G +G+
Sbjct: 1   MSRVLKIASRKSALAKLQTYLVLDALKKKFPNIQIELHFREASGDLDLQTPLWKMGTRGV 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F ++L   L+E + D+ +HS KD+ +E   G  +V + +R D RD  +          P+
Sbjct: 61  FTQDLTKDLVEKKVDLVIHSWKDLDLEGHSGTTIVGVLDRADQRDVLLWKKSSLSKNFPS 120

Query: 122 GSIVGTSSLRRQCQLAERRPD----------LIIRSLRGNVGTRLSKLDNGEYDAIILAV 171
              + TSS RR+  L +   +          LI   +RGN+ TR+ K  N + D ++LA 
Sbjct: 121 ELKIQTSSPRREYNLKKFLNNSLPSRYKNSSLIFLPVRGNIQTRIRKWRNSDSDGLVLAK 180

Query: 172 AGLKRL----------------------GLESRIRAALPPEISLPAVGQGAVGIECRLDD 209
           A L RL                       LE  I   LP  +S  A  QGA+  E R DD
Sbjct: 181 AALDRLLSEDFLNSNELEYQEIRKFLKEILEESIFQVLPLSLSPSAPAQGAIAAEVRTDD 240

Query: 210 SRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGS 248
                 + AL+  E    V  ER    R  GGC   IG 
Sbjct: 241 EWALGFVRALSKPEVVSAVEEERNTLKRFGGGCHQKIGV 279


>UniRef50_B0SF66 Bifunctional porphobilinogen deaminase/uroporphyrinogen synthase
           n=2 Tax=Leptospira biflexa serovar Patoc
           RepID=B0SF66_LEPBA
          Length = 511

 Score =  261 bits (668), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 88/314 (28%), Positives = 136/314 (43%), Gaps = 37/314 (11%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   ++I  R S L+  Q H V + L   +  L  E +   + GD  L TPL + GG+G+
Sbjct: 1   MSETIKIGGRSSLLSRIQIHTVTNALKEKNKDLNFETIFRESSGDKDLTTPLWQFGGQGI 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F K+L+  LL ++ DI +HS KD+ ++  +   L+ +  RED RD  +      ++ LP 
Sbjct: 61  FTKDLQEDLLNHKVDIVIHSYKDMDLKERKETTLIPVLPREDVRDVLLFKKNKWIN-LPN 119

Query: 122 GSIVGTSSLRRQC----QLAERRPD------LIIRSLRGNVGTRLSKLDNGEYDAIILAV 171
              + TSS RR+      L    P       + I S+RGN+ TRL K  + E   I++A 
Sbjct: 120 EITILTSSPRREYHIKEFLRNYFPTPINNFEIKIESVRGNIQTRLRKYLDHESGGILVAK 179

Query: 172 AGLKRL----------------------GLESRIRAALPPEISLPAVGQGAVGIECRLDD 209
           A L R+                       +   +   LP  I   A  QGA+  E R +D
Sbjct: 180 AALDRILNFQDPDQLLPELKEIQQLIKDTMNVSLFMVLPSSIFPSAPAQGALCAEIRKED 239

Query: 210 SRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYA--ELIDGEIWLRALVGAPD 267
                LL+ ++  ET L    ER + +R  GGC   IG            ++R +    D
Sbjct: 240 KHLETLLSKISDSETNLTTNEEREILSRYGGGCHQKIGVTVLHREYGKVCFIRGI--TED 297

Query: 268 GSQIIRGERRGAPQ 281
           G  +   E   +P 
Sbjct: 298 GQILQTKELSESPN 311


>UniRef50_A7BMK1 Porphobilinogen deaminase n=1 Tax=Beggiatoa sp. SS
           RepID=A7BMK1_9GAMM
          Length = 211

 Score =  261 bits (668), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 123/209 (58%), Positives = 148/209 (70%), Gaps = 1/209 (0%)

Query: 101 REDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD 160
           RE+P DAFVSN Y +L ALP G+IVGTSSLRRQ QL   RPDL IRSLRGNVGTRLSKLD
Sbjct: 3   REEPFDAFVSNTYATLAALPEGAIVGTSSLRRQSQLLAHRPDLQIRSLRGNVGTRLSKLD 62

Query: 161 NGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALN 220
           NG+YDAI+LA  GLKRLGL  RIR  +   I LPA+GQGA+GIECR DD  TR+ +  LN
Sbjct: 63  NGDYDAIVLAAVGLKRLGLVERIREIIDSTIMLPAIGQGAIGIECRQDDLETRQHIDNLN 122

Query: 221 HHETALRVTAERAMNTRLEGGCQVPIGSYAEL-IDGEIWLRALVGAPDGSQIIRGERRGA 279
             +T   V AERA+N  LEGGCQVPI  YAE+     + +R LVG  +G  I+R   +GA
Sbjct: 123 DPDTQDCVIAERALNESLEGGCQVPIAGYAEIQSSENLTMRGLVGDIEGQHILRHNLQGA 182

Query: 280 PQDAEQMGISLAEELLNNGAREILAEVYN 308
              A ++G SLA+ LL  GA +IL ++ +
Sbjct: 183 RHLAAELGKSLAKVLLTQGAAQILEKLKD 211


>UniRef50_A5K0J5 Porphobilinogen deaminase, putative n=1 Tax=Plasmodium vivax
           RepID=A5K0J5_PLAVI
          Length = 341

 Score =  258 bits (661), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 91/337 (27%), Positives = 147/337 (43%), Gaps = 69/337 (20%)

Query: 45  GDVILDTPLAKVGGKGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDP 104
           GD ILD  +   GGKG+F KEL+  L++    I VHS+KDVP+E P+ + L    +R+  
Sbjct: 2   GDHILDKKVGLFGGKGIFTKELDEQLIKKNVHICVHSLKDVPMELPEHVQLSCFLKRDTI 61

Query: 105 RDAFVSNNYDSLDALPAGS---------------------------------------IV 125
            DAF+S  Y +L+ +                                            +
Sbjct: 62  NDAFLSVKYATLEDMNKRKMANKVEEESDQEKGTIQQMTNQGLKRDNCEGDKCTNFIPTI 121

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
           GTSSLRR  Q+     ++ ++++RGN+ TR++KL NG+YDAII+A  GL+RL  +  +R 
Sbjct: 122 GTSSLRRSSQIKYTYKNVAVKNVRGNINTRIAKLCNGQYDAIIIAKCGLERLLTKKVVRN 181

Query: 186 AL------PPEISL------------------------PAVGQGAVGIECRLDDSRTREL 215
            +      PPE  L                        PA+ QG + +    +D  T  +
Sbjct: 182 IIRGKGKVPPEKFLLNHNDMETNLRLLRIQQINRRTIYPALCQGIIAVTSHKNDVDTSNI 241

Query: 216 LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE 275
           L  +N  +  +    ER+   ++EG C +PIG YA+++ GEI   A++    G +     
Sbjct: 242 LKNINDEKAQIMANVERSFLYQIEGNCMMPIGGYAQIVGGEIVFNAVINDTHGREKYHVR 301

Query: 276 RRGAPQDAEQMGISLAEELLNNGAREILAEVYNGDAP 312
             G  Q+   +    A ++          ++    A 
Sbjct: 302 EVGTVQNCNNIAAMAATKMKEKIGTHRFNKIKEEAAQ 338


>UniRef50_B1ZV87 Porphobilinogen deaminase n=2 Tax=Opitutaceae RepID=B1ZV87_OPITP
          Length = 284

 Score =  254 bits (649), Expect = 4e-66,   Method: Composition-based stats.
 Identities = 94/260 (36%), Positives = 126/260 (48%), Gaps = 15/260 (5%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             L +ATR+SPLAL Q   V   L A   G+  EL+ +VT GD   +  L + GGKGLF 
Sbjct: 2   KKLILATRKSPLALRQTEMVAAHLEAR-LGVQTELLKLVTTGDRQTEWSLEQKGGKGLFT 60

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
            ELE AL    AD+AVHS KD+P +    L +     R D RD  V         + A  
Sbjct: 61  SELENALRRGEADLAVHSTKDLPGDMAAELAVAGYLPRADARDVLVLRAG-----VAAPK 115

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESR 182
            + T S RR+ Q+A+  P +    +RGNV TRL K+   G  D  +LA AGL RLG+ + 
Sbjct: 116 SLATGSPRRRLQIAKLYPGVTFTEIRGNVDTRLKKIGELGVADGTVLASAGLNRLGIGNW 175

Query: 183 IRAALP---PEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLE 239
                        +PAVGQGA+ ++CR  D+      A +    T   V  ERA    L 
Sbjct: 176 PGVEFHALGFNDMVPAVGQGAIAVQCRAADAA---RFAPVFDAATKRAVDVERAFQAALG 232

Query: 240 GGCQVPIGSYAELIDGEIWL 259
            GCQ   G++  +    +  
Sbjct: 233 VGCQTAFGAH--VAGDTLHF 250


>UniRef50_Q86ET2 Clone ZZD1450 mRNA sequence n=3 Tax=Schistosoma japonicum
           RepID=Q86ET2_SCHJA
          Length = 277

 Score =  243 bits (620), Expect = 7e-63,   Method: Composition-based stats.
 Identities = 100/329 (30%), Positives = 137/329 (41%), Gaps = 75/329 (22%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
             + +R+ +R+S LAL Q       L    P ++ E+V + T GD ILD PL+K+G K L
Sbjct: 6   SQHAVRVGSRRSNLALLQTEMAISLLKVQKPHIMFEVVEIATVGDEILDVPLSKIGDKSL 65

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS---NNYDSLDA 118
           F KELE +LL    D+ VHS+KDVP   P GL L  +  R  P D  +    N    L  
Sbjct: 66  FTKELEKSLLVGEVDLVVHSLKDVPSVLPTGLVLGCVFGRSSPEDVVLMAPHNRGMKLSD 125

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNG--------------EY 164
           LP G+ VGTSS+RR   L  + P L   S+RGN+ TRL+KLD                 Y
Sbjct: 126 LPVGATVGTSSIRRVATLIRKYPHLKFISIRGNLNTRLAKLDTPSNLQKQCCTGNQSLSY 185

Query: 165 DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHET 224
           DA+ILA AG++R+G   RI   L                     DS     L       +
Sbjct: 186 DALILAKAGVERMGWVDRIDQVLS--------------------DSFYANELKGALDASS 225

Query: 225 ALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAE 284
                                +G           LR  +                   A+
Sbjct: 226 VF-------------------MGVAVTPSSEVSRLRMAI-------------------AQ 247

Query: 285 QMGISLAEELLNNGAREILAEVYNGDAPA 313
            +G  +A+ LL +GA EIL E+ +    +
Sbjct: 248 SLGCIVAKYLLLSGAGEILHEIRSQSTES 276


>UniRef50_C0EAN0 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum
           DSM 5476 RepID=C0EAN0_9CLOT
          Length = 292

 Score =  237 bits (605), Expect = 4e-61,   Method: Composition-based stats.
 Identities = 87/293 (29%), Positives = 127/293 (43%), Gaps = 16/293 (5%)

Query: 4   NVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFV 63
             + I   Q+ L+   A ++   L + HP L  ELVP+   G     T         L  
Sbjct: 13  EKIHIGCAQNELSRNFADHLAQCLHSYHPELTAELVPIKNTGADEEPT---------LVA 63

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
           + LE AL++ R D+AV+   D+P+E    L +V I  RED RDA V          P  S
Sbjct: 64  RRLEQALIDCRVDLAVYHALDLPLELHPELPIVAISSREDVRDALVFPQG---KQQPDFS 120

Query: 124 I-VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESR 182
             +G +S R+Q QL    PD I   + G V  +L++LD GEY A++L  A L   GL+ R
Sbjct: 121 KPIGCTSRRQQVQLHRVFPDCITAPVGGTVAEQLARLDQGEYGALVLPAAQLGWFGLQQR 180

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
           +      E  +PA G  A+ ++ R        LL   +  ++   V  ER     LE   
Sbjct: 181 VGQLFCVEELVPAAGHAAIAVQARE--EFDAGLLECFHSWDSWDAVFCEREFARALEEE- 237

Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295
             PI  +AE+    + +                  G  +DA ++G  LA EL 
Sbjct: 238 PGPIAVHAEVKGETLSVVGFYADEAEGIYRMSSMSGDRKDAGRLGFELAAELK 290


>UniRef50_Q6MHU0 Hydroxymethylbilane synthase n=1 Tax=Bdellovibrio bacteriovorus
           RepID=Q6MHU0_BDEBA
          Length = 502

 Score =  235 bits (601), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 82/290 (28%), Positives = 123/290 (42%), Gaps = 37/290 (12%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           LRI+ R+S LA  QA+ V D L   +P + ++     + GD  L  PL K+  KG+F ++
Sbjct: 3   LRISARKSDLARLQAYMVGDALKEKNPQIEIDYRFRESLGDKNLTDPLWKIPEKGVFTED 62

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNY-----DSLDALP 120
               LL +  D+ VHS KD+P E      +     R D RD  +          +   L 
Sbjct: 63  FFGELLRDETDLVVHSWKDLPTEHKSETVIAATLPRADQRDLLLVKKSHFDKIKTSKTL- 121

Query: 121 AGSIVGTSSLRRQCQL----AERRP----DLIIRSLRGNVGTRLSKL-DNGEYDAIILAV 171
               V +SS RR+  L     E  P    D+   S+RGN+ TR+ KL ++ E D +I+A 
Sbjct: 122 ---KVFSSSPRREYNLTGFFKEHLPFGLQDVKFESVRGNMLTRVRKLIESPETDGLIVAK 178

Query: 172 AGLKRLG-----------------LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRE 214
           A   RL                          LP  ++  A  QGA+ +E        ++
Sbjct: 179 AAFDRLFSATLPEFLEGQQQLRQYFNELNWVVLPLSVNPNAAAQGALAVEVLKSRQDLQD 238

Query: 215 LLAALNHHETALRVTAERAMNTRLEGGCQVPIG--SYAELIDGEIWLRAL 262
           LL +++H +T      ER + +   GGC   IG    A        L+ L
Sbjct: 239 LLQSIHHADTFHCSQKERDVLSSFGGGCHQKIGVAVLARPYGQITLLKGL 288


>UniRef50_Q4E9D5 Porphobilinogen deaminase (Fragment) n=1 Tax=Wolbachia endosymbiont
           of Drosophila ananassae RepID=Q4E9D5_9RICK
          Length = 199

 Score =  233 bits (594), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 81/202 (40%), Positives = 121/202 (59%), Gaps = 6/202 (2%)

Query: 97  TICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRL 156
            + ER  P DAF+S+ ++SL++LP  + + TS++RR+ QL   RPDL I  LRGNV TRL
Sbjct: 1   CVLERLSPCDAFISHKHNSLESLPQQATIATSAIRRKVQLLNFRPDLNIVPLRGNVTTRL 60

Query: 157 SKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELL 216
               N  +D IILA AGL RL     I   LPP++ L AVGQGA+ I+CR +D +  +LL
Sbjct: 61  ---QNQSFDGIILAEAGLIRLEKHHLITEVLPPKVMLSAVGQGAICIQCRRNDVKIIDLL 117

Query: 217 AALNHHETALRVTAERAMNTRLEGGCQVPIGSYAE-LIDGEIWLRALVGAPDGSQIIRGE 275
             +N++ + + V +ER+    + G C  P+ + AE + +  ++LR ++   DG  I   E
Sbjct: 118 EKINNNMSFIGVKSERSFMKTVNGSCFTPLAALAEYVSENMLYLRCMLA--DGKNIYFTE 175

Query: 276 RRGAPQDAEQMGISLAEELLNN 297
           R    +DAE+MG+    EL + 
Sbjct: 176 RTSFIEDAEKMGMDAGLELKSK 197


>UniRef50_B6YQR9 Hydroxymethylbilane synthase/uroporphyrin-III
           C-methyltransferase/uroporphyrinogen-III synthase n=1
           Tax=Candidatus Azobacteroides pseudotrichonymphae
           genomovar. CFP2 RepID=B6YQR9_AZOPC
          Length = 682

 Score =  225 bits (574), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 80/226 (35%), Positives = 119/226 (52%), Gaps = 18/226 (7%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG- 60
               LR+ +R SPL+L Q   V     +  P +  +L+ + + GD      L  +     
Sbjct: 7   SKGNLRVISRNSPLSLLQVKEV----FSFFPNIDYQLITIESFGDKNKHVALFDISNVSS 62

Query: 61  ----------LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVS 110
                      F +EL+ AL+ N+ADIAVHS KD+P   P  L L  + +  D  D+ +S
Sbjct: 63  FFLEEESISDFFTRELDEALIYNKADIAVHSAKDLPYPLPYDLELFALFQAMDKSDSLIS 122

Query: 111 NNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILA 170
            N  +L+ LP  + VGTSS +R+ +L + RPDL + S+RGN+  R++K+DNG  DA+I+A
Sbjct: 123 RNNLTLEQLPPRARVGTSSQKRKTELLKIRPDLEVVSIRGNIEERIAKMDNGFIDALIVA 182

Query: 171 VAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELL 216
              L RLG+E+RI   LP E       QG + I  R +D   + L 
Sbjct: 183 TCALIRLGMEARIACILPFETH---SLQGNLAIVGRKNDKNVKNLF 225


>UniRef50_Q6MEK3 Putative Porphobilinogen deaminase n=2 Tax=Parachlamydiaceae
           RepID=Q6MEK3_PARUW
          Length = 233

 Score =  224 bits (571), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 3/218 (1%)

Query: 6   LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVKE 65
           + +  R SPL+  Q   +   L + +P +   +    T GD+   T L  +     F KE
Sbjct: 18  ISVGARSSPLSRAQVQEILKALRSFYPSIEFTISYFDTIGDLDQKTSLRDLDKTNFFTKE 77

Query: 66  LEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIV 125
           ++ A+L+ +  I +HS KD+P   P GL L+ + +  D  D  V  + ++L  LP  S +
Sbjct: 78  IDEAILQKKCQIGIHSAKDLPDPIPDGLQLICLTKGVDCSDVLVLRDGETLQTLPPHSRI 137

Query: 126 GTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRA 185
            TSS+RR+  +   R D I   LRG +  RL+ L+  + D +++A A L RLGL    R 
Sbjct: 138 ATSSIRRENIVKLLRNDFIFLDLRGTIHQRLALLEKKQADGVVVAEAALIRLGLTHLNRI 197

Query: 186 ALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHE 223
            LP        GQG + I  R DD++ + L A L+  +
Sbjct: 198 RLPGTTV---EGQGQLAIIARKDDAKMQTLFACLDVRK 232


>UniRef50_B4UXX3 Porphobilinogen deaminase 2 (Fragment) n=1 Tax=Streptomyces sp. Mg1
           RepID=B4UXX3_9ACTO
          Length = 231

 Score =  223 bits (568), Expect = 8e-57,   Method: Composition-based stats.
 Identities = 88/231 (38%), Positives = 120/231 (51%), Gaps = 13/231 (5%)

Query: 1   MLDN-----VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAK 55
           M+ +      +R+ TR SP+AL Q     D   A +P +V+++V +V+ GD     PL+ 
Sbjct: 1   MMTSSTDLTTVRLGTRPSPMALEQTGRFADVFRARYPQVVLDIVEIVSEGDRHRG-PLST 59

Query: 56  VGGKGLFVKELEVALLENRADIAVHSMKDVPVEFP--QGLGLVTICEREDPRDAFVSNNY 113
           +GGKG F +  +  LL+ R    +   KDVP       G+ +  +  RED RDA V    
Sbjct: 60  IGGKGAFTRNADRYLLDGRVQATIACAKDVPGPHDRSPGIVIAAVLPREDTRDALVLPTG 119

Query: 114 D---SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDA--II 168
               +L  LP G+ VGTS+ RR   L    P L+   +RGN  +RL  LD G   A  +I
Sbjct: 120 HPVTTLAELPPGTRVGTSAPRRSALLKALHPTLVQVPIRGNADSRLRALDAGRLGADVMI 179

Query: 169 LAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAAL 219
            A+AGL+RLG E R    L P + LPA G G V +E R DD  T  LLA L
Sbjct: 180 AALAGLRRLGHEDRASEILDPAVWLPAAGAGTVIVEHRSDDPATGWLLAPL 230


>UniRef50_A8I2X7 Porphobilinogen deaminase n=1 Tax=Chlamydomonas reinhardtii
           RepID=A8I2X7_CHLRE
          Length = 380

 Score =  218 bits (557), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 102/319 (31%), Positives = 137/319 (42%), Gaps = 36/319 (11%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMA----SHPGLVVELVPMVTRGDVILDTPLAKVGG 58
              L IATR S LA  Q   V+  L+A        L +  + + +RGD      L  +G 
Sbjct: 60  QRPLVIATRPSKLAKEQTRQVQQLLLAAAQLKDEQLQLSTLELASRGDTTQGVSLRSLG- 118

Query: 59  KGLFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDA 118
            G F +EL+ A+L   AD++VHS+KD P     GL L     R DPRD  ++    SL  
Sbjct: 119 SGAFTEELDQAVLSGAADMSVHSLKDCPAALAPGLLLAACLPRADPRDVLIAPEATSLGE 178

Query: 119 LPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLG 178
           L  GS VGTSS RR  Q+    P L +  LRGNV +RL ++ + +  A +LA AGLKRLG
Sbjct: 179 LVPGSRVGTSSSRRAAQIKHSFPHLQVVQLRGNVDSRLGRIRSRDIGATVLAAAGLKRLG 238

Query: 179 LESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTR- 237
           + +                 GAVG+ CR DD     LL A++H  TAL V AERA     
Sbjct: 239 VMNSDEGD--------TTATGAVGVVCRADDEWVVGLLDAISHRGTALEVAAERACLAAL 290

Query: 238 --------------LEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER----RGA 279
                         +   C        +     + L  LV   +G ++ R          
Sbjct: 291 LGGGGACQRSAFPDIAWACHTRH----DPDSNTMDLDCLVADLEGKELFRYTEFYRPVID 346

Query: 280 PQDAEQMGISLAEELLNNG 298
             DA  +G      L    
Sbjct: 347 EVDAVSLGSLYGSLLRMMA 365


>UniRef50_Q6Q923 Predicted porphobilinogen deaminase n=2 Tax=environmental samples
           RepID=Q6Q923_9GAMM
          Length = 291

 Score =  210 bits (535), Expect = 5e-53,   Method: Composition-based stats.
 Identities = 82/252 (32%), Positives = 115/252 (45%), Gaps = 17/252 (6%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGL-VVELVPMVTRGDVILDTPLAKVGGKGLFV 63
            ++IA+R S LAL Q      K      G+   +++ + T GD I       +  K  FV
Sbjct: 2   TIKIASRSSKLALAQVEEFVKKF-----GISDYKIIKVKTEGD-IKSANGETLFDKAHFV 55

Query: 64  KELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGS 123
            +++  LL   ADIAVHS KD P     GL L      +  +D  +    D  ++     
Sbjct: 56  SDVQKCLLNGEADIAVHSAKDTPAGETTGL-LRYFLPSQSNQDVLIFREEDKFNS---EM 111

Query: 124 IVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRI 183
            +GTSSLRRQ Q       + I +L GNV TRL KL  GEYD IILA AGL RL L + +
Sbjct: 112 KLGTSSLRRQLQAKHHLNAINIVNLSGNVDTRLEKLSQGEYDCIILAKAGLARLKLLNEL 171

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSR--TRELLAALN--HHETALRVTAERAMNTRLE 239
           +  +       A GQG + IE   D S      LL ++          ++ ER++   + 
Sbjct: 172 QYEVM--DWSTASGQGFLCIEVLNDPSADIYNFLLKSIREIDLNLGKNISTERSILEAIN 229

Query: 240 GGCQVPIGSYAE 251
            GC   I    +
Sbjct: 230 AGCNSAISIQTQ 241


>UniRef50_Q9PK95 Probable porphobilinogen deaminase n=13 Tax=Chlamydiaceae
           RepID=HEM3_CHLMU
          Length = 242

 Score =  207 bits (528), Expect = 3e-52,   Method: Composition-based stats.
 Identities = 69/197 (35%), Positives = 105/197 (53%), Gaps = 3/197 (1%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            LR+A+R+SPLA+ QAH    +L    P L  +++   T+GD+   TPL  V   G F  
Sbjct: 20  PLRLASRKSPLAVLQAHECLRRLQTFFPRLWGQVITETTQGDLDQHTPLHSVENTGFFTD 79

Query: 65  ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSI 124
           +++  +   + D+A+HS KD+P E P+   +  I    DPRD  V      L   P+   
Sbjct: 80  DIDFLVQSGKCDLAIHSAKDLP-EKPKARVI-AITASIDPRDILVFQEKYLLQPFPSRLR 137

Query: 125 VGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIR 184
           +G SS RR+  ++   P  +I  +RG + TRL+ LD  ++DAI++A A + RLGL     
Sbjct: 138 IGCSSDRRRALISSLYPSAVITDIRGTIQTRLALLDQQKFDAIVMANAAVSRLGLRLPCT 197

Query: 185 AALPPEISLPAVGQGAV 201
             LPP    P  G+ A+
Sbjct: 198 VVLPPPYH-PFQGRLAI 213


>UniRef50_D0RNS6 Putative porphobilinogen deaminase (Pbg)(Hydroxymethylbilane
           synthase) (Hmbs) (Pre-uroporphyrinogen synthase) n=1
           Tax=alpha proteobacterium HIMB114 RepID=D0RNS6_9RICK
          Length = 492

 Score =  203 bits (517), Expect = 6e-51,   Method: Composition-based stats.
 Identities = 79/281 (28%), Positives = 120/281 (42%), Gaps = 28/281 (9%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
           +   L I +R S LA  Q   VK +L      + +      T+GD        K  G G+
Sbjct: 1   MSLSLIIGSRASFLAKIQTFIVKQELKKKIKNIKITTKYHSTKGDKNQGHMPWKNLGYGI 60

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPA 121
           F   L   L+    +  VHS KD+PV   +      +  R+DPRD  +            
Sbjct: 61  FTTSLTNELINKNFNCVVHSYKDLPVL--KSKTDYYVITRDDPRDVLLVKKKCLNK---K 115

Query: 122 GSIVGTSSLRRQCQLAERRP-----DLIIRSLRGNVGTRLSK-LDNGEYDAIILAVAGLK 175
             IVGTSS RR+  + + +      D+  +++RGNV TRL K +   +YDA+ +A A + 
Sbjct: 116 KFIVGTSSPRRKSSVKDLKDLTGIKDIKTKTIRGNVTTRLLKVISKNQYDAVFMAKAAID 175

Query: 176 R----------------LGLESRIR-AALPPEISLPAVGQGAVGIECRLDDSRTRELLAA 218
           R                L L  + +   LP  I   A  QGA+ +E   +D +T+  L  
Sbjct: 176 RIFKYGNKVDKVETKKFLNLFKKFKPFILPLSIFPTAASQGAIAVEYLKNDKKTKSTLNK 235

Query: 219 LNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWL 259
           +N  +T      ER++  +  GGC + IG   E I    +L
Sbjct: 236 INCKKTLSICNQERSLLKKYGGGCGLDIGITIEEIKNNNFL 276


>UniRef50_C5LJF7 Porphobilinogen deaminase, putative n=5 Tax=Perkinsus marinus ATCC
           50983 RepID=C5LJF7_9ALVE
          Length = 556

 Score =  200 bits (510), Expect = 4e-50,   Method: Composition-based stats.
 Identities = 79/298 (26%), Positives = 115/298 (38%), Gaps = 40/298 (13%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLF 62
            +VL I +R+S LA  Q   + D L     G+ VE       GD  L  PL K+   G+F
Sbjct: 7   PSVLHIGSRRSDLARLQTLMIADLLQDEM-GVKVECHYREAPGDTNLKDPLWKMPETGVF 65

Query: 63  VKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122
              L   L+    D+ VHS KD+P+    G  +V    R DPRD  +       +    G
Sbjct: 66  TSFLRDGLMNGAFDLVVHSWKDLPLAEESGTTVVATLPRADPRDLLLIRRDAIEEMTSEG 125

Query: 123 SI--VGTSSLRRQCQLAERRP-------DLIIRSLRGNVGTRLSKLDNGEY--------- 164
               V +SS RRQ  L             +  R +RGN+ TR+ KL +            
Sbjct: 126 GKLIVLSSSPRRQFNLTPFLESVVPGVTSVQFRDVRGNIQTRMKKLMDPTIHDESLGCRP 185

Query: 165 DAIILAVAGLKRL----------------GLESRIRA-ALPPEISLPAVGQGAVGIECRL 207
             +++A A + R                 G  S  R   LP   +  A  QGA+GIE   
Sbjct: 186 HGLVVAKAAVDRFIRSTREEFKESRQLVQGYISECRCMVLPLSANPTAAAQGALGIEVST 245

Query: 208 --DDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGS--YAELIDGEIWLRA 261
             +    R+++ +LN   T    + E+ +     GGC   IG           ++L  
Sbjct: 246 APEKEHVRKIVRSLNDRSTFDAASKEKELLNSYGGGCHQKIGCTILPRQYGDVLFLCG 303


>UniRef50_Q9HMY5 Probable porphobilinogen deaminase n=2 Tax=Halobacterium salinarum
           RepID=HEM3_HALSA
          Length = 396

 Score =  196 bits (499), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 72/165 (43%), Positives = 96/165 (58%), Gaps = 2/165 (1%)

Query: 1   MLDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKG 60
           M    +R+ATR S LAL QA  V D L        VELV + T GD + D  ++ +G  G
Sbjct: 1   MSSQQIRLATRGSDLALRQAGEVVDTLEDRR--HDVELVEVETEGDRVTDALISDLGKTG 58

Query: 61  LFVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALP 120
            FV+ L+  ++E   D AVHSMKDVP E P+ L +  +  RE+P D  V+ +   L+ LP
Sbjct: 59  AFVRALDQEVMEGTVDAAVHSMKDVPTEVPEDLVVAAVPHRENPADVLVTPDGTDLEDLP 118

Query: 121 AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYD 165
           AGS+VGT+SLRR  Q+   RP L +  +RGNVGTR+ KL      
Sbjct: 119 AGSVVGTASLRRGAQVQAHRPGLDVEPIRGNVGTRVEKLLAPALH 163



 Score =  138 bits (348), Expect = 3e-31,   Method: Composition-based stats.
 Identities = 48/146 (32%), Positives = 70/146 (47%), Gaps = 1/146 (0%)

Query: 163 EYDAIILAVAGLKRLGLESRIR-AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNH 221
           EYDA+++A  GL+R GL   +    L     +PA GQGA+ +  R D      L  AL H
Sbjct: 248 EYDALVMARVGLERTGLLHHVGIEELSTGTHVPATGQGALCVTARRDSDVVDTLRDALEH 307

Query: 222 HETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQ 281
             T + VTAER +   L GGC  PIG +A +    I     V + DGS+ +   R    +
Sbjct: 308 VRTRVEVTAERVVLEELGGGCIAPIGVHALVQGDTIRTAVQVFSQDGSEQVGETRELDAE 367

Query: 282 DAEQMGISLAEELLNNGAREILAEVY 307
                   LA +L + GA +++ +  
Sbjct: 368 QYATDARELAADLRDRGAADLIEDAR 393


>UniRef50_Q18ES3 Hydroxymethylbilane synthase (Porphobilinogen deaminase) n=9
           Tax=Halobacteriaceae RepID=Q18ES3_HALWD
          Length = 394

 Score =  181 bits (461), Expect = 2e-44,   Method: Composition-based stats.
 Identities = 66/157 (42%), Positives = 95/157 (60%), Gaps = 4/157 (2%)

Query: 5   VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
            L +ATR S LAL QA  V++ L        V+L+ + TRGD I D  + ++G  G FV+
Sbjct: 10  TLTLATRGSDLALKQATSVQEALTDER--YEVDLIEVETRGDQIQDELIHQLGKTGAFVR 67

Query: 65  ELEVALLE--NRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAG 122
            L+  +L+    AD AVHSMKD+P + P  L +  I +R  P D  ++ +   L  LP+G
Sbjct: 68  ALDKKVLDPTAEADAAVHSMKDMPTDSPDDLVVAGIPQRAPPGDLLITTDGQRLSDLPSG 127

Query: 123 SIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKL 159
           + +GTSSLRRQ QL ++R D+ +  LRGN+ TR+ KL
Sbjct: 128 ATIGTSSLRRQAQLLDQRTDITVEPLRGNIDTRIEKL 164



 Score =  137 bits (345), Expect = 6e-31,   Method: Composition-based stats.
 Identities = 52/153 (33%), Positives = 76/153 (49%), Gaps = 1/153 (0%)

Query: 156 LSKLDNGEYDAIILAVAGLKRLGLESRIRAA-LPPEISLPAVGQGAVGIECRLDDSRTRE 214
           L +    EYDAI+LA AGL+R GL   I    L     +PA GQGA+ I  + + + T +
Sbjct: 228 LERSVETEYDAIVLAEAGLQRSGLIHHIEYVQLDTTTFVPAPGQGAIAITTQGEANATAQ 287

Query: 215 LLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRG 274
           +  A++H  T +  T ER +   L GGC  PIG +A L    + + A V A DG++ + G
Sbjct: 288 IREAIDHPRTRVETTVERTVLAELGGGCIAPIGVHATLQGEYVHVAAQVFASDGTETVDG 347

Query: 275 ERRGAPQDAEQMGISLAEELLNNGAREILAEVY 307
            R              A +L + GA E++A   
Sbjct: 348 SRNLPVDAHADAAAQFANKLADRGADELIAAAR 380


>UniRef50_UPI000155526F PREDICTED: similar to hydroxymethylbilane synthase n=1
           Tax=Ornithorhynchus anatinus RepID=UPI000155526F
          Length = 218

 Score =  166 bits (420), Expect = 1e-39,   Method: Composition-based stats.
 Identities = 60/130 (46%), Positives = 78/130 (60%), Gaps = 9/130 (6%)

Query: 75  ADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNN---YDSLDALPAGSIVGTSSLR 131
            D+ VHS+KD+P   P G  +  +C+RE P DA V +      +L  LP  S+VGTSSLR
Sbjct: 90  VDLVVHSLKDLPTVLPPGFTIGAVCKRESPYDAVVFHPKHVGKTLATLPEKSVVGTSSLR 149

Query: 132 RQCQLAERRPDLIIRSLRGNVGTRLSKLDN-GEYDAIILAVAGLKRLGLESRIRAALPPE 190
           R  QL  + P L  +S+RGN+ TRL KLD   E+ AIILA AGL+RLG +SR+       
Sbjct: 150 RAAQLQRKFPHLEFKSIRGNLNTRLRKLDELQEFSAIILAAAGLQRLGWQSRLGQV---- 205

Query: 191 ISLPAV-GQG 199
              PA  G+G
Sbjct: 206 RVAPAPRGRG 215


>UniRef50_B0KCR7 Porphobilinogen deaminase n=3 Tax=Thermoanaerobacter
           RepID=B0KCR7_THEP3
          Length = 168

 Score =  161 bits (408), Expect = 3e-38,   Method: Composition-based stats.
 Identities = 48/164 (29%), Positives = 82/164 (50%), Gaps = 7/164 (4%)

Query: 136 LAERRPDLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPA 195
           +     D+ I  +RGNV TRL K++    D I+L+ AGL RLGLES I    PP++ +PA
Sbjct: 4   IQALMSDIQIVPIRGNVRTRLKKMEELNLDGIVLSAAGLHRLGLESIITEYFPPDVVVPA 63

Query: 196 VGQGAVGIECRLD-DSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAEL-- 252
             QG + +E     D+  +E  + +    T    + ER +       C+ P G+YA+   
Sbjct: 64  PCQGILAVEIAESFDNIFQEFYSYIVDRRTFFEASVERELLKAFGVNCRQPFGAYAQYRK 123

Query: 253 --IDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEEL 294
              + +I ++ +    D  ++++ E  G  ++ ++M   L EE 
Sbjct: 124 EKDEEKINIKVVYQKED--KLLKSEVTGLIEETDKMIEKLIEEF 165


>UniRef50_C0DZX9 Putative uncharacterized protein n=1 Tax=Corynebacterium
           matruchotii ATCC 33806 RepID=C0DZX9_9CORY
          Length = 152

 Score =  154 bits (391), Expect = 3e-36,   Method: Composition-based stats.
 Identities = 54/150 (36%), Positives = 79/150 (52%), Gaps = 1/150 (0%)

Query: 156 LSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTREL 215
           ++K+ +GE DA++LA AGL R+           P   LPA  QGA+ +ECR DD+ T   
Sbjct: 1   MAKVHDGELDAVVLAYAGLSRVHRADEATEVFDPLEFLPAPAQGALAVECRADDADTIAA 60

Query: 216 LAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEI-WLRALVGAPDGSQIIRG 274
           +  +   +       ER +  RLE GC  P+ +YA +    I  L A V A DGS  +R 
Sbjct: 61  ITTIADSKAYACAHTERVVLARLEAGCTAPVAAYATVAADNIMTLHAAVIAMDGSATLRA 120

Query: 275 ERRGAPQDAEQMGISLAEELLNNGAREILA 304
              G    AE +G+++A  LL++GA  +LA
Sbjct: 121 TAAGPIDTAENLGMTVARALLDDGASSLLA 150


>UniRef50_UPI0001B4213A porphobilinogen deaminase n=1 Tax=Listeria monocytogenes LO28
           RepID=UPI0001B4213A
          Length = 128

 Score =  144 bits (365), Expect = 3e-33,   Method: Composition-based stats.
 Identities = 51/124 (41%), Positives = 78/124 (62%), Gaps = 2/124 (1%)

Query: 185 AALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQV 244
             +PPE+ LPAVGQGA+ IECR  D + R++L +++H ET + V AER    +L GGC++
Sbjct: 6   EDIPPEVCLPAVGQGALAIECRESDQQIRDMLTSIHHEETGICVEAERVFLKKLNGGCEI 65

Query: 245 PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILA 304
           PI  +A   +  +  + LVG  DGS I+  E+ G   +  ++G  +AE+LL+ GA  I+ 
Sbjct: 66  PIAGFATRANEFVQFKGLVGNADGSIILESEQVG--ANPSEIGNKVAEDLLSEGADTIIK 123

Query: 305 EVYN 308
           E+ N
Sbjct: 124 ELRN 127


>UniRef50_A8CBG6 Porphobilinogen deaminase n=3 Tax=Toxoplasma gondii
           RepID=A8CBG6_TOXGO
          Length = 747

 Score =  143 bits (361), Expect = 8e-33,   Method: Composition-based stats.
 Identities = 56/163 (34%), Positives = 74/163 (45%), Gaps = 33/163 (20%)

Query: 124 IVGTSSLRRQCQLAERRP--DLIIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGL-- 179
            +GT SLRRQ  L    P     +  LRGNV TR+S+++ G  DA +LA AGLKRL L  
Sbjct: 444 RIGTCSLRRQALLYALLPPSSFQLMGLRGNVQTRMSRIEKGTLDATLLAAAGLKRLNLLS 503

Query: 180 ---------------------ESRIRAA--------LPPEISLPAVGQGAVGIECRLDDS 210
                                 SR            LP ++ +PAV QG +G++CR  D+
Sbjct: 504 AMLAPSPSATPSPCPAPSPNETSRGTEPGGCVEAVLLPADVFVPAVCQGIIGVQCRSADT 563

Query: 211 RTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELI 253
               LL  LN   +  +   ERA    L+G C+ PI   AE  
Sbjct: 564 GILSLLRELNSPSSRGQALCERAFLRALDGSCRTPIAGIAEWR 606



 Score =  117 bits (295), Expect = 4e-25,   Method: Composition-based stats.
 Identities = 44/96 (45%), Positives = 56/96 (58%), Gaps = 3/96 (3%)

Query: 23  VKDKLMASHPGLVV---ELVPMVTRGDVILDTPLAKVGGKGLFVKELEVALLENRADIAV 79
           V   L+     L      +VPM T GD  L  PLA+VGGKGLF KEL++ALL  + D+ V
Sbjct: 253 VLASLLRVDSRLEYGELRIVPMQTTGDKELHLPLAQVGGKGLFTKELDLALLHGQVDVVV 312

Query: 80  HSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDS 115
           HS+KDVP E P+G  +     REDPRDA + +    
Sbjct: 313 HSLKDVPTELPEGTEIGAYLPREDPRDALIFSRKPR 348



 Score = 52.4 bits (125), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 18/67 (26%), Positives = 32/67 (47%), Gaps = 5/67 (7%)

Query: 247 GSYAELIDGEI-WLRALVGAPDGSQIIRGERRG----APQDAEQMGISLAEELLNNGARE 301
           G  A     ++     ++  PDG Q+ R ER       P++AE +G ++AEE+      +
Sbjct: 669 GVLATPDGKQLLRFCGVLATPDGKQLFREERTVRGVRTPEEAEALGRAVAEEIKKAAGAD 728

Query: 302 ILAEVYN 308
            LA++  
Sbjct: 729 RLAQIKK 735



 Score = 44.3 bits (104), Expect = 0.006,   Method: Composition-based stats.
 Identities = 12/31 (38%), Positives = 15/31 (48%)

Query: 3   DNVLRIATRQSPLALWQAHYVKDKLMASHPG 33
              LR+ +R SPLAL QA     +L    P 
Sbjct: 160 KTPLRVGSRASPLALAQARQFVYRLALRFPD 190


>UniRef50_UPI0001742E92 Porphobilinogen deaminase n=1 Tax=candidate division TM7
           single-cell isolate TM7a RepID=UPI0001742E92
          Length = 119

 Score =  133 bits (335), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 32/115 (27%), Positives = 60/115 (52%), Gaps = 2/115 (1%)

Query: 183 IRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGC 242
           +      +  +PA GQG + I+CR +D++ R LL  +N  E  +   AER  +   +GGC
Sbjct: 1   MSEYFDTDFFMPAPGQGILCIQCRENDNKIRHLLEIINDDEVTMMCEAEREFSKIFDGGC 60

Query: 243 QVPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNN 297
             PIG  + +    + L+ +    +GS++++ E  G  ++ +++   LAEE+   
Sbjct: 61  HTPIGCSSVIEGDTLKLKGM-FNDNGSRMLK-EVEGNKENPKEIAQKLAEEIKKE 113


>UniRef50_C4Z1K5 Putative uncharacterized protein n=1 Tax=Eubacterium eligens ATCC
           27750 RepID=C4Z1K5_EUBE2
          Length = 287

 Score =  126 bits (317), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 48/242 (19%), Positives = 96/242 (39%), Gaps = 34/242 (14%)

Query: 55  KVGGKGLFVKELEVALLENRADIAVHSMKDVPV---------EFPQGLGLVTICEREDPR 105
           ++GG  ++   LE AL+++  D+    + D+ +         +   G+ +  + +R DPR
Sbjct: 42  EIGGSDIY-PALE-ALIDDNIDMV---LVDMRMLVEMEKSGQQLDDGIVISGVIKRRDPR 96

Query: 106 DAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEYD 165
              +         +   ++V T S      + E   ++    +  N+   +SKLD+ E D
Sbjct: 97  YVMIRRRGT--KDVVENAVVVTDSDENAAVICEMYDNVECV-VENNIKDCMSKLDSEECD 153

Query: 166 AIILAV---AGLKRL--GLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALN 220
           A + A      + RL  GL+ +    +     +P  GQG   I      S  + +   ++
Sbjct: 154 A-VFAFYDDIRIARLYNGLKYKYT-LMDFSDCVPPHGQGIYCILTNGKRSVIKHMFD-VS 210

Query: 221 HHETALRVTAERAMNTRLEG-----GCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGE 275
           H  TA+    E  +  RL        C     +Y ++   +I + A V    G+  ++ +
Sbjct: 211 HRTTAMSFDIEEDIIRRLLMNDYVKSCN----AYVKISGDKIEVYADVKGYRGNIKVQEK 266

Query: 276 RR 277
             
Sbjct: 267 DE 268


>UniRef50_Q401C3 Hydroxymethylbilane synthase (Fragment) n=7 Tax=Coelomata
           RepID=Q401C3_CAPHI
          Length = 109

 Score =  124 bits (311), Expect = 6e-27,   Method: Composition-based stats.
 Identities = 44/93 (47%), Positives = 59/93 (63%), Gaps = 4/93 (4%)

Query: 104 PRDAFVSNN---YDSLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLD 160
           P +A V +      +L+ LP  S+VGTSSLRR  QL  + P L  R++RGN+ TRL KLD
Sbjct: 17  PMNAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRNIRGNLNTRLRKLD 76

Query: 161 N-GEYDAIILAVAGLKRLGLESRIRAALPPEIS 192
              E+ AIILA AGL+R+G ++R+   L PE  
Sbjct: 77  ELQEFSAIILAAAGLQRMGWQNRVGQILHPEEC 109


>UniRef50_UPI0001698669 porphobilinogen deaminase n=1 Tax=Endoriftia persephone
           'Hot96_1+Hot96_2' RepID=UPI0001698669
          Length = 136

 Score =  120 bits (302), Expect = 5e-26,   Method: Composition-based stats.
 Identities = 64/133 (48%), Positives = 79/133 (59%), Gaps = 11/133 (8%)

Query: 172 AGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAE 231
           AGLKRLG E RI A + PE SLPA+GQGA+GIECR DD++   L+A L+H +TA  V AE
Sbjct: 8   AGLKRLGFEQRITAFIAPEQSLPAIGQGAIGIECRSDDAQVNALIAPLHHVDTAACVHAE 67

Query: 232 RAMNTRLEGG-----CQV-PIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQ 285
           RAMN RL GG     C++   G  A       W R+ V      +   GE  G P +AE 
Sbjct: 68  RAMNNRLMGGSPCADCRLRDAGVPATSGCVVWWARSTVA-----RSCVGEAEGTPDEAES 122

Query: 286 MGISLAEELLNNG 298
           +G+ LAE LL  G
Sbjct: 123 LGVGLAERLLELG 135


>UniRef50_Q1HRH6 Hydroxymethylbilane synthase-like protein n=1 Tax=Aedes aegypti
           RepID=Q1HRH6_AEDAE
          Length = 349

 Score =  118 bits (297), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 34/111 (30%), Positives = 52/111 (46%), Gaps = 6/111 (5%)

Query: 177 LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNT 236
           +G E RI   + P   L AVGQGA+ +ECR +D     +L+ L H ET  ++  ER+   
Sbjct: 1   MGWEKRIDQVIEPSEILYAVGQGALAVECRSNDEYILNMLSKLCHLETQCKILVERSFLK 60

Query: 237 RLEGGCQVPIGSYAEL------IDGEIWLRALVGAPDGSQIIRGERRGAPQ 281
            L GGC  P+     L          + ++  V + DG   IR +   + +
Sbjct: 61  TLGGGCSAPVAVCTSLKRKHDSKSNYLNIQGAVWSLDGKTEIRADDGCSVE 111


>UniRef50_C5G109 Porphobilinogen deaminase n=1 Tax=Microsporum canis CBS 113480
           RepID=C5G109_NANOT
          Length = 282

 Score =  112 bits (280), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 54/233 (23%), Positives = 81/233 (34%), Gaps = 48/233 (20%)

Query: 84  DVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGTSSLRRQCQLAERRPDL 143
           DV  + P       I  +           Y SL  LP G+I+ TS +R   QL    P L
Sbjct: 93  DVSTKLPDSCDPAAIPVKA-------GLPYTSLQTLPEGAIIATSLVRPSAQLRRLFPTL 145

Query: 144 IIRSLRGNVGTRLSKLDNGEYDAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGI 203
              ++RGNV +            + +  A    LG         P         QG    
Sbjct: 146 RFANVRGNVES------------LTIPQA----LGTVGSSTRGRPRARRR--RHQGY--- 184

Query: 204 ECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALV 263
                 + + + L AL    + L           L  GC  PIG   E     + +RA+V
Sbjct: 185 ----SSAGSADRLLAL---PSVLMC--------ALRSGCNAPIGIETEWTATHLSIRAIV 229

Query: 264 GAPDGSQIIRGERRG---APQDAEQMGISLAEELLNNGAREILAEVYNGDAPA 313
            + D SQ +            +++  G +LA  L   G   IL ++ N + P+
Sbjct: 230 VSLDISQSVEDAIDAMMHTKDESDAPGQALA-RLFGAGVAPILIDI-NRNQPS 280


>UniRef50_B8N6H4 Putative uncharacterized protein n=1 Tax=Aspergillus flavus
          NRRL3357 RepID=B8N6H4_ASPFN
          Length = 90

 Score =  100 bits (250), Expect = 6e-20,   Method: Composition-based stats.
 Identities = 30/79 (37%), Positives = 40/79 (50%)

Query: 5  VLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGLFVK 64
           LRI TR+S LA+ QA  +++ L    PG   E+  + T GD    T L   G K L+  
Sbjct: 10 PLRIGTRRSNLAMVQAEGIRNCLQKIAPGRSFEIEALRTLGDRDQLTALYNFGAKSLWTT 69

Query: 65 ELEVALLENRADIAVHSMK 83
          ELE  L     D+ VH +K
Sbjct: 70 ELEEKLNAGELDVIVHCLK 88


>UniRef50_UPI0000D9FBB5 PREDICTED: similar to lethal (3) 02640 CG9165-PA n=1 Tax=Macaca
           mulatta RepID=UPI0000D9FBB5
          Length = 105

 Score = 99.8 bits (248), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 34/113 (30%), Positives = 45/113 (39%), Gaps = 17/113 (15%)

Query: 2   LDNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAKVGGKGL 61
            +  LRI +R+S LA  Q   V D+L     G  V LV M                  G+
Sbjct: 5   SNATLRIGSRRSDLARLQTLMVADRLEE--MGYKVVLVGM---------------PETGV 47

Query: 62  FVKELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD 114
           F   L   LL+   D+ VHS KD+P+    G  +     R DPRD  +     
Sbjct: 48  FTTFLRQKLLDGSVDLVVHSWKDLPLAEEAGTTVAATLPRADPRDLIIIRKDA 100


>UniRef50_UPI0001C35DE1 porphobilinogen deaminase n=1 Tax=Clostridium hathewayi DSM 13479
           RepID=UPI0001C35DE1
          Length = 121

 Score = 89.0 bits (220), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 25/112 (22%), Positives = 47/112 (41%), Gaps = 3/112 (2%)

Query: 184 RAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAMNTRLEGGCQ 243
                 E  +PA GQG + +E R++D R  E+   +   +    +  ER +   L+ GC 
Sbjct: 13  FHYFACEAFIPAGGQGILAVEGRIED-RICEMAVRIQDEDAKTCLMLERKILKLLDAGCH 71

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELL 295
            P+G Y+ +   EI +  +  +    +  R    G   + + +    A+ L 
Sbjct: 72  EPVGVYSRIRGEEIEVFGI--SRRDRETKRVYLTGGIGELDLLAERAAKGLR 121


>UniRef50_C5U771 Porphobilinogen deaminase n=1 Tax=Methanocaldococcus infernus ME
           RepID=C5U771_9EURY
          Length = 89

 Score = 73.6 bits (180), Expect = 9e-12,   Method: Composition-based stats.
 Identities = 24/83 (28%), Positives = 34/83 (40%), Gaps = 3/83 (3%)

Query: 217 AALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQIIRGER 276
             +N  +T L  TAER     L  GC VP G++A+     + L+  V   D         
Sbjct: 2   EKINDKKTFLETTAERKALNELGCGCHVPFGAFAKYEGKRLMLKVAVANKDRVIKKESSI 61

Query: 277 RGAPQD---AEQMGISLAEELLN 296
                +   AE++G SL  EL  
Sbjct: 62  CCEVDEIEKAEKLGESLGRELRR 84


>UniRef50_Q4EB45 Porphobilinogen deaminase n=1 Tax=Wolbachia endosymbiont of
          Drosophila ananassae RepID=Q4EB45_9RICK
          Length = 62

 Score = 62.8 bits (152), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 20/50 (40%), Positives = 30/50 (60%)

Query: 6  LRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDVILDTPLAK 55
          ++I TR S LA+ QA   K KL+ S P L +E+V + + GD   +  LA+
Sbjct: 13 VKIGTRGSKLAVVQALEAKQKLLDSFPNLSIEIVKIKSSGDKYANANLAE 62


>UniRef50_B5XH53 Porphobilinogen deaminase n=1 Tax=Salmo salar RepID=B5XH53_SALSA
          Length = 55

 Score = 59.7 bits (144), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 15/39 (38%), Positives = 22/39 (56%)

Query: 3  DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPM 41
            V+RI TR S LA  Q   V +KL   +P + +E+V +
Sbjct: 16 SRVIRIGTRNSQLARIQTDSVAEKLKGLYPDVHIEIVGI 54


>UniRef50_C2BR76 Putative uncharacterized protein (Fragment) n=1 Tax=Corynebacterium
           pseudogenitalium ATCC 33035 RepID=C2BR76_9CORY
          Length = 62

 Score = 59.0 bits (142), Expect = 2e-07,   Method: Composition-based stats.
 Identities = 16/62 (25%), Positives = 32/62 (51%)

Query: 244 VPIGSYAELIDGEIWLRALVGAPDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREIL 303
            P+ + +     ++ +R  V A DGS+ +     G+  +A  +G  +++EL   GA E+L
Sbjct: 1   APVAATSRWDGDQLTVRGGVFALDGSRQLTATASGSAAEAADLGARISDELFAGGAAELL 60

Query: 304 AE 305
            +
Sbjct: 61  GK 62


>UniRef50_UPI0000D537E6 hypothetical protein P700755_22735 n=1 Tax=Psychroflexus torquis
           ATCC 700755 RepID=UPI0000D537E6
          Length = 356

 Score = 55.5 bits (133), Expect = 3e-06,   Method: Composition-based stats.
 Identities = 46/234 (19%), Positives = 83/234 (35%), Gaps = 38/234 (16%)

Query: 68  VALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYDSLDALPAGSIVGT 127
            +L +   D+   S  D   +  +GL +  +  R++P    V+N+    + L  G+ +  
Sbjct: 49  QSLRDGAGDLVAMSAFDWQQQDVEGLIIAGLLTRKEPTWVLVANDKP--EYLKQGAYILC 106

Query: 128 S--SLRRQCQLAERRPDLIIRSL-----RGNVGTRLSKLDN-------------GEYDAI 167
               LRR  Q+   R DL + ++     R N    +S+LD              G  D  
Sbjct: 107 DHELLRR--QMMRLRGDLTLETMEEMGKRLNAAATISELDEEDIWPWVEGLLKNGNIDGF 164

Query: 168 ILAVA--GLKR-------LGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAA 218
           I+  A     R       LGL+     +   E  +P    G   +  R    +    +  
Sbjct: 165 IVPRAIHASHRMKSRRHTLGLQRDNSES-NRERFIPPPLHGFTMLVGRNGFPKAS--IQD 221

Query: 219 LNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVGAPDGSQII 272
           +      L    E A+   LE   +  +G++ E    +I       + DG + +
Sbjct: 222 MVDQSAELAYRLEAAILESLEPSLRPIVGAFVEQR--KIATILKKASEDGDEAL 273


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.312    0.171    0.535 

Lambda     K      H
   0.267   0.0525    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 2,502,518,840
Number of Sequences: 3077464
Number of extensions: 137751043
Number of successful extensions: 330475
Number of sequences better than 1.0e-01: 231
Number of HSP's better than  0.1 without gapping: 680
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 327984
Number of HSP's gapped (non-prelim): 799
length of query: 313
length of database: 1,040,396,356
effective HSP length: 128
effective length of query: 185
effective length of database: 646,480,964
effective search space: 119598978340
effective search space used: 119598978340
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.0 bits)
S2: 94 (40.5 bits)
