BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for composition-based statistics:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (282 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_Q0T1R0 NADPH-dependent 7-cyano-7-deazaguanine reductase...   433   e-120
UniRef50_Q0HGT5 NADPH-dependent 7-cyano-7-deazaguanine reductase...   398   e-109
UniRef50_Q7WH69 NADPH-dependent 7-cyano-7-deazaguanine reductase...   387   e-106
UniRef50_Q1K442 GTP cyclohydrolase I n=2 Tax=Proteobacteria RepI...   383   e-105
UniRef50_A4VK37 GTP cyclohydrolase I, putative n=2 Tax=Gammaprot...   382   e-105
UniRef50_A4T050 GTP cyclohydrolase I n=2 Tax=Proteobacteria RepI...   380   e-104
UniRef50_Q0VR70 NADPH-dependent 7-cyano-7-deazaguanine reductase...   377   e-103
UniRef50_Q5P6G9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   375   e-103
UniRef50_Q6ARX8 NADPH-dependent 7-cyano-7-deazaguanine reductase...   370   e-101
UniRef50_Q1LSV9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   363   4e-99
UniRef50_Q5X7D5 NADPH-dependent 7-cyano-7-deazaguanine reductase...   360   2e-98
UniRef50_Q21VW6 NADPH-dependent 7-cyano-7-deazaguanine reductase...   359   7e-98
UniRef50_Q6FA61 NADPH-dependent 7-cyano-7-deazaguanine reductase...   357   2e-97
UniRef50_B8KG68 NADPH-dependent 7-cyano-7-deazaguanine reductase...   349   7e-95
UniRef50_C8PYF2 Queuine synthase n=3 Tax=Moraxellaceae RepID=C8P...   348   1e-94
UniRef50_A4A3I6 GTP cyclohydrolase I n=1 Tax=Congregibacter lito...   344   2e-93
UniRef50_A8F0H9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   341   1e-92
UniRef50_Q1QDK8 NADPH-dependent 7-cyano-7-deazaguanine reductase...   340   3e-92
UniRef50_B8KRQ4 NADPH-dependent 7-cyano-7-deazaguanine reductase...   331   2e-89
UniRef50_A0Z1W1 Putative uncharacterized protein n=1 Tax=marine ...   329   8e-89
UniRef50_P44165 Uncharacterized protein HI1340 n=9 Tax=Gammaprot...   298   2e-79
UniRef50_Q6WI29 GTP cyclohydrolase I family protein n=1 Tax=Vibr...   282   9e-75
UniRef50_B7RUV0 GTP cyclohydrolase I subfamily, putative n=1 Tax...   216   7e-55
UniRef50_B8DRK9 7-cyano-7-deazaguanine reductase n=2 Tax=Desulfo...   165   2e-39
UniRef50_A9VKS1 NADPH-dependent 7-cyano-7-deazaguanine reductase...   165   2e-39
UniRef50_Q2IH01 NADPH-dependent 7-cyano-7-deazaguanine reductase...   163   8e-39
UniRef50_B3E3W5 7-cyano-7-deazaguanine reductase n=3 Tax=Proteob...   162   2e-38
UniRef50_C7JB01 Queuosine biosynthesis protein QueF n=9 Tax=Alph...   162   2e-38
UniRef50_Q3SJI1 NADPH-dependent 7-cyano-7-deazaguanine reductase...   159   9e-38
UniRef50_C4XPJ6 Putative uncharacterized protein n=1 Tax=Desulfo...   159   1e-37
UniRef50_Q0AAV5 NADPH-dependent 7-cyano-7-deazaguanine reductase...   158   2e-37
UniRef50_C7M0Q2 7-cyano-7-deazaguanine reductase n=1 Tax=Acidimi...   157   4e-37
UniRef50_B8IYG6 NADPH-dependent 7-cyano-7-deazaguanine reductase...   156   8e-37
UniRef50_Q9ZJJ9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   154   4e-36
UniRef50_D2L9R9 7-cyano-7-deazaguanine reductase n=1 Tax=Desulfo...   153   5e-36
UniRef50_Q8GJN6 NADPH-dependent 7-cyano-7-deazaguanine reductase...   153   5e-36
UniRef50_Q8UD54 NADPH-dependent 7-cyano-7-deazaguanine reductase...   153   6e-36
UniRef50_Q6MRJ2 NADPH-dependent 7-cyano-7-deazaguanine reductase...   152   2e-35
UniRef50_A6C8E2 Putative uncharacterized protein n=2 Tax=Plancto...   152   2e-35
UniRef50_A1WY83 NADPH-dependent 7-cyano-7-deazaguanine reductase...   151   2e-35
UniRef50_Q2LTJ0 NADPH-dependent 7-cyano-7-deazaguanine reductase...   149   1e-34
UniRef50_D1N404 7-cyano-7-deazaguanine reductase n=3 Tax=Bacteri...   146   7e-34
UniRef50_B2UN89 7-cyano-7-deazaguanine reductase n=2 Tax=Verruco...   146   7e-34
UniRef50_B3QM19 NADPH-dependent 7-cyano-7-deazaguanine reductase...   144   4e-33
UniRef50_A8ZUH0 GTP cyclohydrolase I n=2 Tax=Desulfobacteraceae ...   142   1e-32
UniRef50_D2REX4 GTP cyclohydrolase I n=1 Tax=Archaeoglobus profu...   142   1e-32
UniRef50_B3EMR0 NADPH-dependent 7-cyano-7-deazaguanine reductase...   142   2e-32
UniRef50_B7J648 NADPH-dependent 7-cyano-7-deazaguanine reductase...   142   2e-32
UniRef50_Q04RM8 NADPH-dependent 7-cyano-7-deazaguanine reductase...   141   3e-32
UniRef50_C0GIY6 7-cyano-7-deazaguanine reductase n=1 Tax=Dethiob...   139   1e-31
UniRef50_Q8DNP8 NADPH-dependent 7-cyano-7-deazaguanine reductase...   139   1e-31
UniRef50_Q8DMA3 NADPH-dependent 7-cyano-7-deazaguanine reductase...   137   3e-31
UniRef50_Q2J7K4 NADPH-dependent 7-cyano-7-deazaguanine reductase...   136   7e-31
UniRef50_B2KDU6 NADPH-dependent 7-cyano-7-deazaguanine reductase...   136   9e-31
UniRef50_B8HRW7 7-cyano-7-deazaguanine reductase n=2 Tax=Cyanoba...   136   1e-30
UniRef50_A6Q0W4 NADPH-dependent 7-cyano-7-deazaguanine reductase...   135   1e-30
UniRef50_B5IMF1 7-cyano-7-deazaguanine reductase n=1 Tax=Cyanobi...   133   5e-30
UniRef50_B0CDX9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   133   6e-30
UniRef50_Q113I7 NADPH-dependent 7-cyano-7-deazaguanine reductase...   132   2e-29
UniRef50_C1CXM3 Putative GTP cyclohydrolase I n=2 Tax=Deinococcu...   131   2e-29
UniRef50_B4U9Q5 7-cyano-7-deazaguanine reductase n=5 Tax=Bacteri...   130   4e-29
UniRef50_B0KAC5 NADPH-dependent 7-cyano-7-deazaguanine reductase...   129   8e-29
UniRef50_B7JWF0 7-cyano-7-deazaguanine reductase n=8 Tax=Cyanoba...   128   2e-28
UniRef50_Q5HS73 NADPH-dependent 7-cyano-7-deazaguanine reductase...   128   2e-28
UniRef50_A5IIZ4 NADPH-dependent 7-cyano-7-deazaguanine reductase...   125   1e-27
UniRef50_A8W229 ATP-dependent metalloprotease FtsH n=1 Tax=Bacil...   125   1e-27
UniRef50_B5JRC9 7-cyano-7-deazaguanine reductase n=1 Tax=Verruco...   125   1e-27
UniRef50_B5IBP5 7-cyano-7-deazaguanine reductase n=2 Tax=Aciduli...   120   4e-26
UniRef50_D0MDN3 7-cyano-7-deazaguanine reductase n=1 Tax=Rhodoth...   105   2e-21
UniRef50_Q9YBX9 Putative GTP cyclohydrolase I n=1 Tax=Aeropyrum ...    77   9e-13
UniRef50_A2BLN0 Predicted GTP cyclohydrolase I n=1 Tax=Hyperther...    73   8e-12
UniRef50_B1YDZ8 GTP cyclohydrolase I n=5 Tax=Thermoproteaceae Re...    52   2e-05
UniRef50_B1SCE4 Putative uncharacterized protein n=1 Tax=Strepto...    45   0.004

>UniRef50_Q0T1R0 NADPH-dependent 7-cyano-7-deazaguanine reductase n=139
           Tax=Gammaproteobacteria RepID=QUEF_SHIF8
          Length = 282

 Score =  433 bits (1113), Expect = e-120,   Method: Composition-based stats.
 Identities = 280/282 (99%), Positives = 281/282 (99%)

Query: 1   MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLY 60
           MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLY
Sbjct: 1   MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLY 60

Query: 61  ELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLS 120
           ELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLS
Sbjct: 61  ELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLS 120

Query: 121 TCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEET 180
           TCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENAT GEKVVEET
Sbjct: 121 TCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATSGEKVVEET 180

Query: 181 LVSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDL 240
           LVSHLLKSNCLITHQPDWGS+QIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDL
Sbjct: 181 LVSHLLKSNCLITHQPDWGSIQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDL 240

Query: 241 LRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           LRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ
Sbjct: 241 LRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282


>UniRef50_Q0HGT5 NADPH-dependent 7-cyano-7-deazaguanine reductase n=142
           Tax=Proteobacteria RepID=QUEF_SHESM
          Length = 286

 Score =  398 bits (1022), Expect = e-109,   Method: Composition-based stats.
 Identities = 177/279 (63%), Positives = 219/279 (78%)

Query: 4   YANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELS 63
           Y++ + LAGLTLGK+TDY+  YDASLLQGVPRSLNR+ + L A++LPFHG DIWT YELS
Sbjct: 8   YSDAKELAGLTLGKATDYQAEYDASLLQGVPRSLNRNAINLTAESLPFHGADIWTAYELS 67

Query: 64  WLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCA 123
           WLNAKG P VA+  ++L + S NLIESKSFKLYLNSFNQT+F+N D V++TL +DLS CA
Sbjct: 68  WLNAKGKPMVAIADIQLSHESQNLIESKSFKLYLNSFNQTKFDNIDAVQKTLVQDLSECA 127

Query: 124 QGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVS 183
           QG+++V +        Q +    GTCIDD DI + +Y+F  DYLEN+T  +++V ETL S
Sbjct: 128 QGQVTVKIIEPKSFGIQRVVELPGTCIDDLDIEVSDYDFNPDYLENSTDDKQIVAETLNS 187

Query: 184 HLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRF 243
           +LLKSNCLIT QPDWGS+ I+Y+G +IDREKLLRYL+SFR HNEFHEQCVERIF DL  +
Sbjct: 188 NLLKSNCLITSQPDWGSVMIRYQGPKIDREKLLRYLISFRQHNEFHEQCVERIFVDLKHY 247

Query: 244 CQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           C   KL+VYARYTRRGGLDINP+RS+ +    + RL RQ
Sbjct: 248 CHCTKLTVYARYTRRGGLDINPYRSDFEHPGESHRLARQ 286


>UniRef50_Q7WH69 NADPH-dependent 7-cyano-7-deazaguanine reductase n=5
           Tax=Proteobacteria RepID=QUEF_BORBR
          Length = 273

 Score =  387 bits (994), Expect = e-106,   Method: Composition-based stats.
 Identities = 142/276 (51%), Positives = 173/276 (62%), Gaps = 4/276 (1%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNA 67
            +L+   LG+   Y   YD  LL  +PR+ NR  L L    LPF G D+W  YELSWL+A
Sbjct: 1   MSLSNAPLGQHVAYPSQYDPGLLFPIPRATNRASLQL-GATLPFTGVDLWNAYELSWLDA 59

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKI 127
           +G P+VA+        S N++ESKSFKLYLNSFNQTR  N   +R  LERDL+  A   +
Sbjct: 60  RGKPRVAMATFSFPADSPNIVESKSFKLYLNSFNQTRLPNAQALRDRLERDLAAAAGAPV 119

Query: 128 SVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLK 187
            +            +   +G  ID  DI ID YE     L+ A   E  VEETL + LLK
Sbjct: 120 GLEFISPQRFGELNMAELDGIYIDKLDIEIDTYEPAPQLLQCAPGDE--VEETLATRLLK 177

Query: 188 SNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           SNC +T QPDW SLQ++YRGR IDR  LL+Y+VSFR H EFHE CVERIF D++R CQP 
Sbjct: 178 SNCPVTGQPDWASLQVRYRGRPIDRAALLKYVVSFRQHAEFHEHCVERIFGDIMRACQPR 237

Query: 248 KLSVYARYTRRGGLDINPWRSNSD-FVPSTTRLVRQ 282
           +L+VYARYTRRGGLDINPWRSN +   P+  R  RQ
Sbjct: 238 QLTVYARYTRRGGLDINPWRSNFESAPPADVRTARQ 273


>UniRef50_Q1K442 GTP cyclohydrolase I n=2 Tax=Proteobacteria RepID=Q1K442_DESAC
          Length = 275

 Score =  383 bits (984), Expect = e-105,   Method: Composition-based stats.
 Identities = 148/275 (53%), Positives = 182/275 (66%), Gaps = 1/275 (0%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNA 67
             L  + LGK+T+Y   YDA LL  VPR L RD LG+ ++ LPF+G D+W  YELSWLN 
Sbjct: 2   SDLTEIPLGKTTEYPSQYDAGLLYPVPRHLKRDELGI-SEPLPFYGEDVWNSYELSWLNR 60

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKI 127
           KG P VA+        S NL+ESKSFKLYLNS NQTRF++   V   L+RDLS  +   +
Sbjct: 61  KGKPVVALAVFRFSCQSPNLVESKSFKLYLNSLNQTRFDDQQAVIDCLQRDLSQASGSSV 120

Query: 128 SVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLK 187
           +V L  LD+     +    G C+D  D+ +++Y+   D L +A      VEETL SHLLK
Sbjct: 121 TVELSSLDDQSLWQVQTLPGECLDSVDLDVEHYQLNADLLRDAADSADPVEETLYSHLLK 180

Query: 188 SNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           SNCLIT QPDW S+ I YRG +++R  LL YL+SFR HNEFHEQCVERIF DL+R+C P+
Sbjct: 181 SNCLITSQPDWASVWISYRGGRLERRALLAYLISFRQHNEFHEQCVERIFADLMRYCHPQ 240

Query: 248 KLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
            L+VYARYTRRGGLDINPWRS         RL RQ
Sbjct: 241 SLTVYARYTRRGGLDINPWRSTEPGTAPQWRLSRQ 275


>UniRef50_A4VK37 GTP cyclohydrolase I, putative n=2 Tax=Gammaproteobacteria
           RepID=A4VK37_PSEU5
          Length = 298

 Score =  382 bits (982), Expect = e-105,   Method: Composition-based stats.
 Identities = 142/277 (51%), Positives = 177/277 (63%), Gaps = 2/277 (0%)

Query: 6   NHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWL 65
            H A     LGKS+DY  TY   LL  +PR+     LGL A+ LP+ G D+W  YELSWL
Sbjct: 24  QHPAEHS-PLGKSSDYVATYSPGLLFPIPRAPKWVELGLTAETLPYQGVDLWNCYELSWL 82

Query: 66  NAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQG 125
              G P VA+G  E+   S ++IESKSFKLYLNS NQ+ F + + + + +  DLS  A  
Sbjct: 83  LPSGKPVVAIGEFEIPADSPSIIESKSFKLYLNSLNQSVFESREALAEVMSSDLSAAAGK 142

Query: 126 KISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHL 185
            + V L  LDE+  + +    G C+DD D+TI++Y+     L     G  +VEE+L SHL
Sbjct: 143 PVKVRLRTLDEVAAEGVATLPGRCVDDLDVTIEHYDHPQPGLLACDAG-HMVEESLHSHL 201

Query: 186 LKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQ 245
           LKSNC +T QPDWGS+ ++YRG  +  E LL YLVSFR H +FHEQCVERIF DL R  Q
Sbjct: 202 LKSNCPVTGQPDWGSVVVEYRGAALQAESLLAYLVSFRQHADFHEQCVERIFLDLQRLLQ 261

Query: 246 PEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           PEKL+VYARY RRGGLDINP+RS    V    RLVRQ
Sbjct: 262 PEKLTVYARYVRRGGLDINPYRSTGAMVVDNRRLVRQ 298


>UniRef50_A4T050 GTP cyclohydrolase I n=2 Tax=Proteobacteria RepID=A4T050_POLSQ
          Length = 275

 Score =  380 bits (975), Expect = e-104,   Method: Composition-based stats.
 Identities = 138/275 (50%), Positives = 176/275 (64%), Gaps = 2/275 (0%)

Query: 10  LAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGL-KADNLPFHGTDIWTLYELSWLNAK 68
           +A L LG+ST Y D YD SLL  +PR+ NR  LGL +   LPF G DIW  +ELSWLN K
Sbjct: 1   MATLPLGQSTQYPDQYDPSLLFPIPRTENRAKLGLKEGQALPFVGIDIWNAFELSWLNQK 60

Query: 69  GLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKIS 128
           G PQ+A+   ++   S N+IESKSFKLYLNS N  RF +  +V+  L  DLS  A  K++
Sbjct: 61  GKPQIALAEFQIPADSPNMIESKSFKLYLNSLNSARFEDEGQVKDRLITDLSAVAGSKVA 120

Query: 129 VALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKS 188
             ++  + +  + +   +G  +D  DI ID +      L         +E+ LVSHLLKS
Sbjct: 121 TRIHSTEAVSKKGMQEMSGILMDRLDIEIDPHLPADPSLLGVNESFGPIEQCLVSHLLKS 180

Query: 189 NCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEK 248
           NC +T QPDW S+QI+Y+GR I  E LLRYL+ FR   EFHE CVE IF D+ R C+PEK
Sbjct: 181 NCPVTGQPDWASVQIRYQGRPILEEGLLRYLIGFRQLGEFHEHCVETIFTDIKRQCKPEK 240

Query: 249 LSVYARYTRRGGLDINPWRSNSDFV-PSTTRLVRQ 282
           LSVYARYTRRGGLDINP+R++ +   P  TR  RQ
Sbjct: 241 LSVYARYTRRGGLDINPFRTDHNSPWPENTRHARQ 275


>UniRef50_Q0VR70 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2
           Tax=Alcanivorax RepID=QUEF_ALCBS
          Length = 274

 Score =  377 bits (968), Expect = e-103,   Method: Composition-based stats.
 Identities = 128/273 (46%), Positives = 175/273 (64%), Gaps = 2/273 (0%)

Query: 10  LAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKG 69
           L    LG+S++Y D Y  SLL  VPR   R+ L L++  LPFHG+DIW  YELSWLN KG
Sbjct: 4   LKETPLGRSSEYVDQYMPSLLCPVPRWDAREGLELESATLPFHGSDIWNAYELSWLNEKG 63

Query: 70  LPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISV 129
            P VA+  + +  T+ N++ESKS KLYLNSF  TRF + D VR  +E+D++  A G I V
Sbjct: 64  KPIVAMCELRVPCTTPNIVESKSLKLYLNSFANTRFQSRDAVRAAIEKDVAQTAGGNIEV 123

Query: 130 ALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSN 189
            L+ L E  G P+    G C+D+ D+  ++YE+  D L      E+  +  L SHLL+S+
Sbjct: 124 LLFSLQESAGFPVWEDRGDCVDNIDLNFEHYEYRPDLLLCDQGPEQTGQ--LYSHLLRSH 181

Query: 190 CLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKL 249
           C +T QPDW ++ ++Y GR I     LRY+VS R+H  FHEQ +E++F DL+  C P  L
Sbjct: 182 CPVTDQPDWATVVVRYTGRAISPASFLRYVVSLRNHQGFHEQIIEQMFVDLMTQCSPRHL 241

Query: 250 SVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           +VY R+TRRGG+DINP+RSNS+      R +RQ
Sbjct: 242 TVYGRFTRRGGIDINPFRSNSEQPLPNRRTIRQ 274


>UniRef50_Q5P6G9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=1
           Tax=Aromatoleum aromaticum EbN1 RepID=QUEF_AZOSE
          Length = 283

 Score =  375 bits (964), Expect = e-103,   Method: Composition-based stats.
 Identities = 147/282 (52%), Positives = 180/282 (63%), Gaps = 3/282 (1%)

Query: 2   SSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYE 61
           S   +H A A   LG+S  YRD+Y   LL  + R + RD LGL  D LPF G D+W  YE
Sbjct: 4   SDTHDHGAEAS-PLGQSVVYRDSYAPELLFPIARQIKRDELGLAPDTLPFVGEDLWNAYE 62

Query: 62  LSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLST 121
           LSWLN++G P  A+G   +  TS  LIESKS KLYLNSFNQ RF +   V  TL RDLST
Sbjct: 63  LSWLNSRGKPVAAIGTFRVPVTSPRLIESKSLKLYLNSFNQHRFVDPTLVHDTLTRDLST 122

Query: 122 CAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETL 181
            A   ++V++  L     +  G+ +G  +D+ DI ID Y     +L+ +      V ETL
Sbjct: 123 AAGAPVAVSIEVLSRRPTRVFGYPHGVLLDEIDIEIDTYRTDPAFLQ-SDFNADEVSETL 181

Query: 182 VSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLL 241
            SHLLKSNCL+T QPDWG++ ++Y G  IDR  LLRY+VSFR HNEFHEQCVERIF D+L
Sbjct: 182 YSHLLKSNCLVTGQPDWGTIVLRYIGPPIDRAGLLRYIVSFRSHNEFHEQCVERIFCDVL 241

Query: 242 RFCQPEKLSVYARYTRRGGLDINPWRSNSDFV-PSTTRLVRQ 282
           R C P  L+V+ARYTRRGGLDINP+RS   F        VRQ
Sbjct: 242 RRCAPRHLAVWARYTRRGGLDINPFRSTGHFTQFDNIAEVRQ 283


>UniRef50_Q6ARX8 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2
           Tax=Proteobacteria RepID=QUEF_DESPS
          Length = 276

 Score =  370 bits (949), Expect = e-101,   Method: Composition-based stats.
 Identities = 133/274 (48%), Positives = 172/274 (62%), Gaps = 6/274 (2%)

Query: 11  AGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGL 70
           AG+ LGK   + +TYD S L  V R   R  LGL AD+LPF G DIW  YELSWL++KG 
Sbjct: 7   AGIPLGKQVGHSETYDPSHLFPVARREARKSLGL-ADDLPFSGPDIWNAYELSWLDSKGK 65

Query: 71  PQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVA 130
           P VA+G +    TS N+IESKS KLYLNSFN TRF +   V++ +  DLS  A  ++ V 
Sbjct: 66  PCVALGEITFPCTSENIIESKSLKLYLNSFNLTRFTSTARVKEIIREDLSRVAGAEVEVK 125

Query: 131 LYRLDELEGQPIGHFNGTCIDDQDI--TIDNYEFTTDYLENATCGEKVVEETLVSHLLKS 188
           +   +E     I    G+CIDD ++   I+ Y  T +YL          EE L ++LL++
Sbjct: 126 ILTPEEFTEVTISAPEGSCIDDLELEEEINAYRPTANYLSTGPEE---TEEELYTNLLRT 182

Query: 189 NCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEK 248
           NC +T QPDW ++ I YRG+ ID+  LLRY++SFR H  FHE CVERIF D+L  C P +
Sbjct: 183 NCPVTGQPDWATVIINYRGKAIDQRGLLRYIISFRQHEGFHENCVERIFMDILNRCAPAR 242

Query: 249 LSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           L+VYAR+TRRGGLDINP+R+         RL RQ
Sbjct: 243 LTVYARFTRRGGLDINPYRTTHAEHFVNLRLARQ 276


>UniRef50_Q1LSV9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2
           Tax=Gammaproteobacteria RepID=QUEF_BAUCH
          Length = 283

 Score =  363 bits (932), Expect = 4e-99,   Method: Composition-based stats.
 Identities = 153/281 (54%), Positives = 195/281 (69%), Gaps = 4/281 (1%)

Query: 5   ANHQALAGLTLGKS-TDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELS 63
             +Q L    L KS   YR  Y+  LLQ +PR+++R+ LG+ + +LPF G D WTLYELS
Sbjct: 4   QQYQLLQKFKLDKSKISYRTHYNPMLLQPIPRTIHRELLGISSISLPFQGADFWTLYELS 63

Query: 64  WLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCA 123
           WLN  GLPQVA+G + +D TS NLIES+S KLYLNS NQT F++  E+R TL  D++ C 
Sbjct: 64  WLNKYGLPQVAIGEMIIDATSDNLIESQSLKLYLNSINQTCFSSEQELRNTLITDITKCI 123

Query: 124 QGKISVALYRLDELEGQPIGHFNGTCIDDQDITI--DNYEFTTDYLENATCGEKVVEETL 181
             ++ + ++ L +    PI  F G CID+Q I I  DNY F ++ L N+   EK V+ETL
Sbjct: 124 NSQVKITIHSLSQWMTVPILEFTGECIDNQSIQIDNDNYIFNSNLLVNSVEREK-VKETL 182

Query: 182 VSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLL 241
           VSHLLKSNC IT+QPDWGS+QI Y G +I+RE LLRYL+SFR +  FHEQCVE+I+ D++
Sbjct: 183 VSHLLKSNCPITNQPDWGSVQISYYGMRINREALLRYLISFRKYKIFHEQCVEQIYCDIM 242

Query: 242 RFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           +FC P  LSVY RY RRGGLDINPWRSN  + P    L RQ
Sbjct: 243 QFCLPNTLSVYVRYNRRGGLDINPWRSNISYSPVNRPLARQ 283


>UniRef50_Q5X7D5 NADPH-dependent 7-cyano-7-deazaguanine reductase n=43 Tax=Bacteria
           RepID=QUEF_LEGPA
          Length = 285

 Score =  360 bits (925), Expect = 2e-98,   Method: Composition-based stats.
 Identities = 134/271 (49%), Positives = 180/271 (66%), Gaps = 6/271 (2%)

Query: 15  LGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVA 74
           LG++ +Y   Y+   L  +PR+  R  + L  ++  F+G D W  YE+SWLN+KG P VA
Sbjct: 18  LGQTANYDSYYNPKRLYPIPRAPKRQEINLDPNSTTFYGFDCWNHYEVSWLNSKGKPVVA 77

Query: 75  VGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRL 134
           +  +  D  S  +IESKS KLY NS N + F + + V QT+ +DLS C   +++V +Y L
Sbjct: 78  MAVISYDCHSPCIIESKSLKLYFNSLNNSTFPDVETVVQTISKDLSHCIGSEVAVNVYPL 137

Query: 135 DELEGQPI-GHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLIT 193
            E+  Q I   F+G C+D  DI    Y    D+L  ++   K+VEE L S LLKSNCL+T
Sbjct: 138 SEIASQTIYAAFDGICLDKLDIECSVYHVMPDFLSTSS---KLVEEVLYSDLLKSNCLVT 194

Query: 194 HQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYA 253
           +QPDWGS+QI Y+G++I+ E LL+YL+SFR+HNEFHEQC+ERIF D++RFCQPE L+VY 
Sbjct: 195 NQPDWGSVQIIYKGKKINHEGLLKYLISFRNHNEFHEQCIERIFADIMRFCQPESLAVYG 254

Query: 254 RYTRRGGLDINPWRSNS--DFVPSTTRLVRQ 282
           RYTRRGGLDINP RS     F     RL+RQ
Sbjct: 255 RYTRRGGLDINPIRSTEPCAFDGQNIRLIRQ 285


>UniRef50_Q21VW6 NADPH-dependent 7-cyano-7-deazaguanine reductase n=143
           Tax=Proteobacteria RepID=QUEF_RHOFD
          Length = 289

 Score =  359 bits (921), Expect = 7e-98,   Method: Composition-based stats.
 Identities = 140/287 (48%), Positives = 175/287 (60%), Gaps = 17/287 (5%)

Query: 11  AGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGL 70
               LG++T Y D YDASLL  + R+  R  +G+    LPF G D+WT +ELSWLN +G 
Sbjct: 5   QNSPLGQATAYLDQYDASLLFPIARATKRAEIGVTG-ALPFLGADMWTAFELSWLNLRGK 63

Query: 71  PQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTC-------- 122
           PQVA+    +   S N+IESKSFKLYLNSFN TRF + D V+  L  DLS          
Sbjct: 64  PQVALARFTVPCESPNIIESKSFKLYLNSFNNTRFADVDAVKARLRADLSEAVWRDAGKN 123

Query: 123 ------AQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKV 176
                 A   I V L   +  + +PI   +G  +D  D+   +Y    D L      E  
Sbjct: 124 VSPDAAAPPSIGVTLLLPELFDREPIYELDGLSLDRLDVECTHYTPAPDLL-RVVPDEAP 182

Query: 177 VEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERI 236
           V E LVS+LLKSNC +T QPDW S+QI Y G  ID+E LL+YLVSFR+HNEFHEQCVERI
Sbjct: 183 VSEVLVSNLLKSNCPVTGQPDWASVQISYSGAPIDQEGLLQYLVSFRNHNEFHEQCVERI 242

Query: 237 FNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDF-VPSTTRLVRQ 282
           F DL   C+P +L+VYARYTRRGGLDINP+R++    +P+  R  RQ
Sbjct: 243 FMDLWTRCKPVRLAVYARYTRRGGLDINPFRTSYAQALPANVRNARQ 289


>UniRef50_Q6FA61 NADPH-dependent 7-cyano-7-deazaguanine reductase n=16
           Tax=Acinetobacter RepID=QUEF_ACIAD
          Length = 271

 Score =  357 bits (917), Expect = 2e-97,   Method: Composition-based stats.
 Identities = 120/277 (43%), Positives = 165/277 (59%), Gaps = 8/277 (2%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLG-LKADNLPFHGTDIWTLYELSWLN 66
            ++    LGK T+Y  TY  S+L  + R   R+    ++  +    G D W ++ELSWLN
Sbjct: 1   MSVEQSLLGKETEYPTTYSPSVLFPISRDAAREKYAQIEGIS---QGKDWWHVFELSWLN 57

Query: 67  AKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGK 126
           +  +PQVA+G + L  TS  LIESKS KLY NS N   F +  E+   +E+DLS  A  K
Sbjct: 58  SDNIPQVAIGRITLPATSPYLIESKSLKLYFNSLNFHVFASKQELIDLVEKDLSQAANAK 117

Query: 127 ISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLL 186
           +S+ L+ +D LE   I   +G CIDD              L+     +   + TL SHLL
Sbjct: 118 VSLELFDVDSLE---ISKPSGMCIDDLKPERLESHPDASLLKLDANEQHDADVTLYSHLL 174

Query: 187 KSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQP 246
           +SNC +T QPDWG++ I+Y GR+     +L Y++S+R HN FHEQCVE+I+ D+ +  QP
Sbjct: 175 RSNCPVTGQPDWGTVFIRYTGRKHCYRSILAYIISYRQHNGFHEQCVEQIYADIWKNLQP 234

Query: 247 EKLSVYARYTRRGGLDINPWR-SNSDFVPSTTRLVRQ 282
           EKL VYA YTRRGGLDINP R S+  ++P+  RL RQ
Sbjct: 235 EKLMVYATYTRRGGLDINPCRVSDLSWMPNPIRLARQ 271


>UniRef50_B8KG68 NADPH-dependent 7-cyano-7-deazaguanine reductase (Nadph-dependent
           nitrile oxidoreductase) n=1 Tax=gamma proteobacterium
           NOR5-3 RepID=B8KG68_9GAMM
          Length = 276

 Score =  349 bits (895), Expect = 7e-95,   Method: Composition-based stats.
 Identities = 114/285 (40%), Positives = 157/285 (55%), Gaps = 12/285 (4%)

Query: 1   MSSYANHQALA---GLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIW 57
           M  + +   +A   G  LG+       YD  LL  VPR+  R    L        G DIW
Sbjct: 1   MGDHHSAPGVAHDKGPLLGRQVAGSHYYDPGLLFPVPRANARK--SLPGGAFAGFGEDIW 58

Query: 58  TLYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLER 117
             YELSWLNA G+PQ+ +G   +   S N+IESKSFKLYLNS N   F +    R+T+ R
Sbjct: 59  HAYELSWLNASGMPQMFLGTFSVPADSANIIESKSFKLYLNSLNNFEFASDGLARETIVR 118

Query: 118 DLSTCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVV 177
           DLS  A  ++S+ L  +D+          G C+D   +++   E   + LE      +V 
Sbjct: 119 DLSAVAGAQVSLVLKAVDDQRYDG-RVLEGDCLDGFQVSVPE-EPHVELLEPVVGDARVY 176

Query: 178 EETLVSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIF 237
                +HL++S C +T QPDW ++ I+ RG    R+KLL YL+++R+H EFHEQCVER++
Sbjct: 177 -----THLMRSLCPVTAQPDWATMIIETRGTSAQRDKLLSYLLAYRNHQEFHEQCVERVY 231

Query: 238 NDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
            DL +  +P+ LSV A YTRRGGLDI PWR +        R+ RQ
Sbjct: 232 TDLWKRLEPDYLSVQALYTRRGGLDICPWRCSEARPAPQGRMNRQ 276


>UniRef50_C8PYF2 Queuine synthase n=3 Tax=Moraxellaceae RepID=C8PYF2_9GAMM
          Length = 283

 Score =  348 bits (894), Expect = 1e-94,   Method: Composition-based stats.
 Identities = 118/275 (42%), Positives = 165/275 (60%), Gaps = 8/275 (2%)

Query: 15  LGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVA 74
           LG+ST Y  TY   +L  +PR+L R  L L AD L   G D W ++E+SWLN+ G+ QVA
Sbjct: 10  LGQSTSYPKTYAPDMLYPIPRALGRAKLALPADALSI-GMDWWQVFEMSWLNSHGISQVA 68

Query: 75  VGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRL 134
           +  + +  TS  ++ESKS KLY NS N T F+N   V+  +E+DLS C +  +++ ++ +
Sbjct: 69  MVRLAIPATSDYIVESKSLKLYFNSLNFTEFDNQQAVKAAVEKDLSACLKTDVTLEIFEV 128

Query: 135 DELEGQPIGHFNGTCIDDQ------DITIDNYEFTTDYLENATCGEKVVEETLVSHLLKS 188
           +     PI    G CID+        I I +   ++              + L SHLL+S
Sbjct: 129 NIANSLPISAPQGDCIDNALDNSGKKIAIVSDVDSSSLTVADQGASDSQLQILHSHLLRS 188

Query: 189 NCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEK 248
           NC +T+QPDWG+L+IQ   + IDR  LL Y++SFR HN FHEQCVE+IF+DL +   P+ 
Sbjct: 189 NCPVTNQPDWGTLEIQIDSQPIDRAGLLEYILSFRQHNGFHEQCVEQIFSDLTQAFAPKT 248

Query: 249 LSVYARYTRRGGLDINPWR-SNSDFVPSTTRLVRQ 282
           L V A YTRRGG+DINP R S+   +P  +RL RQ
Sbjct: 249 LMVRAWYTRRGGIDINPCRVSDISLLPPPSRLNRQ 283


>UniRef50_A4A3I6 GTP cyclohydrolase I n=1 Tax=Congregibacter litoralis KT71
           RepID=A4A3I6_9GAMM
          Length = 272

 Score =  344 bits (883), Expect = 2e-93,   Method: Composition-based stats.
 Identities = 118/272 (43%), Positives = 158/272 (58%), Gaps = 9/272 (3%)

Query: 11  AGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGL 70
            G  LG+     + YD SLL  VPRS  R    L        G DIW  YELSWL+A G+
Sbjct: 10  KGPLLGQQVVGSEQYDPSLLFPVPRSNARA--SLPEQRFQGFGEDIWHAYELSWLSAAGM 67

Query: 71  PQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVA 130
           PQ  VG   +  TS NLIESKS KLYLNS N  RF + +  RQT+ RDLS  A   +S+ 
Sbjct: 68  PQAFVGTFAIPATSANLIESKSLKLYLNSLNNHRFTSAEAARQTIVRDLSEVAGAPVSLT 127

Query: 131 LYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNC 190
           L   ++   +      G+C+DD ++T+   +     L     G+ +    L +HL++S C
Sbjct: 128 LGSPEDPAFRG-EDLPGSCLDDLEVTVP--DAADPVLLTGVAGDGL----LYTHLMRSLC 180

Query: 191 LITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLS 250
            +T QPDW ++ ++ RG   +   LLRYL+++R+H EFHEQCVERI+ D+L   QP+ LS
Sbjct: 181 PVTAQPDWATVVVETRGVAPESPGLLRYLLAYRNHQEFHEQCVERIYTDILDRLQPDYLS 240

Query: 251 VYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           V+A YTRRGGLDI+PWR +        RL RQ
Sbjct: 241 VHALYTRRGGLDISPWRCSEHQPAPRYRLNRQ 272


>UniRef50_A8F0H9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=14
           Tax=Rickettsia RepID=QUEF_RICM5
          Length = 273

 Score =  341 bits (876), Expect = 1e-92,   Method: Composition-based stats.
 Identities = 120/277 (43%), Positives = 172/277 (62%), Gaps = 6/277 (2%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNA 67
             L+   LGK + Y+D+YD +LL  +PR  NR+ LG+ ++NLPF+G D+W  YELS LN 
Sbjct: 1   MPLSTSLLGKKSTYKDSYDVTLLFKIPRINNRNELGINSNNLPFYGVDVWNTYELSCLNK 60

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKI 127
            G P V VG   +   S N++ESKSFKLYLNSFN     +  E+ + + +DLS     K+
Sbjct: 61  NGKPWVGVGTFYIPTDSENIVESKSFKLYLNSFNNFVVESVKELERIILQDLSNVTHAKV 120

Query: 128 SVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLK 187
           +  ++ ++       G  +G  IDD DI  +NY    + L      + +VEE + S+LLK
Sbjct: 121 TGRIFPIN--TKVEFGVPSGKNIDDLDIVCNNYGAPDNSL--IEYEDVLVEEEINSNLLK 176

Query: 188 SNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           SNCL+T QPDWG++ I+Y+G+++  +  L+YL+SFR+ NEF EQC ERIF D+     P+
Sbjct: 177 SNCLVTGQPDWGTIVIKYKGKKLKHDSFLKYLISFRNCNEFAEQCAERIFTDIKNAISPD 236

Query: 248 KLSVYARYTRRGGLDINPWRSNSDF--VPSTTRLVRQ 282
            LS+   YTRRGG+DI P+RS      +PS  R +RQ
Sbjct: 237 FLSISIVYTRRGGIDICPYRSTDKSYTLPSDKRFIRQ 273


>UniRef50_Q1QDK8 NADPH-dependent 7-cyano-7-deazaguanine reductase n=3
           Tax=Psychrobacter RepID=QUEF_PSYCK
          Length = 285

 Score =  340 bits (873), Expect = 3e-92,   Method: Composition-based stats.
 Identities = 115/286 (40%), Positives = 167/286 (58%), Gaps = 12/286 (4%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNA 67
            ++ G+   ++TDY   Y    L  + RS+ R+ +G + D L   G D W  +ELSWLN 
Sbjct: 1   MSIHGILGEQTTDYPTEYSPETLYPIARSMGREVIGWQDDKLE-VGFDWWQAFELSWLNE 59

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKI 127
           +G+ QVA+    +  +S  ++ESKS KLYLNS N T F + + V+  + +DLS C Q ++
Sbjct: 60  QGISQVAIARFGIPASSPFIVESKSLKLYLNSINFTEFGSLETVQTLIAKDLSKCVQAEV 119

Query: 128 SVALYRL-DELEGQPIGHFNGTCIDDQ-----DITIDNYEFTTDYLENATCGEKVVEET- 180
           +V L+ L DE  G  I   +G CIDD      +            LE  T   K+ E   
Sbjct: 120 NVELFDLEDEHSGLLIAQPDGICIDDALADSTEKVALTLHPDASLLERNTSDAKISEGKT 179

Query: 181 --LVSHLLKSNCLITHQPDWGSLQIQYRG-RQIDREKLLRYLVSFRHHNEFHEQCVERIF 237
               S+LL+SNC +T+QPDWG+L +     + ++   +LRY++SFR HN FHEQCVE+IF
Sbjct: 180 FSFYSNLLRSNCPVTNQPDWGTLAVSITSNKPVNNANMLRYILSFRQHNGFHEQCVEQIF 239

Query: 238 NDLLRFCQPEKLSVYARYTRRGGLDINPWR-SNSDFVPSTTRLVRQ 282
            DL ++ +P +L V A YTRRGG+DINP R S+   +P  +RL+RQ
Sbjct: 240 ADLSQYYEPSELMVRAWYTRRGGIDINPCRVSDIALLPVPSRLIRQ 285


>UniRef50_B8KRQ4 NADPH-dependent 7-cyano-7-deazaguanine reductase n=1 Tax=gamma
           proteobacterium NOR51-B RepID=B8KRQ4_9GAMM
          Length = 267

 Score =  331 bits (848), Expect = 2e-89,   Method: Composition-based stats.
 Identities = 102/274 (37%), Positives = 140/274 (51%), Gaps = 8/274 (2%)

Query: 10  LAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKG 69
           +    LG   D    Y   +L+ V R    + L       P  G D+W LYELSWL+ +G
Sbjct: 1   MVDRVLGSRVDAPTRYSPEILEPVERQRGDERLS------PMLGADVWHLYELSWLSREG 54

Query: 70  LPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISV 129
            P   VG + +  +S   +ESKS KLYLNS N  RF+N      T+ RD+       + +
Sbjct: 55  WPTAFVGALAIPASSPRTVESKSLKLYLNSLNFHRFDNERAAVSTIMRDVQAVVGASVDL 114

Query: 130 ALYRLDELEGQPIGHFNGTCIDD-QDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKS 188
            +    EL  Q      G CIDD     +   ++        + GE  V ETL+SH L+S
Sbjct: 115 TIAAPTEL-AQWTREPAGVCIDDVFSGALVAADWGASRKTPFSQGEDRVSETLISHQLRS 173

Query: 189 NCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEK 248
            C +T QPDWG+L + Y G ++D  +LL ++ SFR H +FHE CVE+I+  L     PE 
Sbjct: 174 LCPVTGQPDWGTLVVDYSGYRLDPAELLSFVCSFREHQDFHEHCVEQIYKKLFGDLSPEA 233

Query: 249 LSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           L+V A Y RRGG+DI PWR +        R+ RQ
Sbjct: 234 LTVTAYYQRRGGIDITPWRGHEKLDAPLWRMGRQ 267


>UniRef50_A0Z1W1 Putative uncharacterized protein n=1 Tax=marine gamma
           proteobacterium HTCC2080 RepID=A0Z1W1_9GAMM
          Length = 267

 Score =  329 bits (843), Expect = 8e-89,   Method: Composition-based stats.
 Identities = 103/273 (37%), Positives = 144/273 (52%), Gaps = 6/273 (2%)

Query: 10  LAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKG 69
           +A   LG+       Y   +L+ + R   R+ LG    ++   G D W LYELSWLN + 
Sbjct: 1   MAVHALGQKVAAPKRYAPDILEAISRREGREALGPAPKSM--VGHDCWHLYELSWLNLRN 58

Query: 70  LPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISV 129
            PQ  VG + +D  S   IESKS KLYLNS N   F +  +  + +  D+    Q  +S+
Sbjct: 59  EPQHCVGVLLVDSASPATIESKSLKLYLNSLNFHCFASEAQACEVICGDIGRVTQSDVSL 118

Query: 130 ALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSN 189
            +   D L         G  ++      D+    + +      G+ +++ T VSH L+S 
Sbjct: 119 TVLPPDGLGA-ITREPEGVLLEADPQQSDHTSMQSPW---CDSGDDILDATYVSHRLRSL 174

Query: 190 CLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKL 249
           C +T QPDWG+L I YRGR I+  +LL ++ SFR H EFHEQCVER F ++++    E L
Sbjct: 175 CPVTAQPDWGTLVIDYRGRPINHHRLLGFIESFREHQEFHEQCVERCFYEVMKQTNAESL 234

Query: 250 SVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
            V A Y RRGG+DI P RSN   VP   R+ RQ
Sbjct: 235 RVSAFYQRRGGIDITPVRSNHRVVPELWRMGRQ 267


>UniRef50_P44165 Uncharacterized protein HI1340 n=9 Tax=Gammaproteobacteria
           RepID=Y1340_HAEIN
          Length = 441

 Score =  298 bits (763), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 129/281 (45%), Positives = 171/281 (60%), Gaps = 18/281 (6%)

Query: 3   SYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFH-GTDIWTLYE 61
           +Y +  +L  L LG+ T+Y   YD +LLQ VPR+LNRD LG+   N PF  G DIWT YE
Sbjct: 2   NYQD-NSLKSLKLGQKTEYASQYDRTLLQPVPRALNRDGLGIT-QNQPFTIGADIWTAYE 59

Query: 62  LSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLST 121
           +SWLN KGLPQVA+  + LDY S NLIESKSFKLYLNSFNQ++F +++ V+QT++RDLS 
Sbjct: 60  ISWLNEKGLPQVAIADIYLDYQSQNLIESKSFKLYLNSFNQSKFTDFNAVQQTMQRDLSE 119

Query: 122 CAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETL 181
           CAQG + V L  +   + Q I H  G CID+QDI I +YEF  ++L++    E +VEE L
Sbjct: 120 CAQGDVKVRLNPVAVYDAQKINHLQGDCIDEQDIEITSYEFNANWLKDCVSNE-IVEEKL 178

Query: 182 VSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIF---- 237
           VSHLLKSNCLIT+QPDWG+ Q Q         KL     +F    +  EQ +  +     
Sbjct: 179 VSHLLKSNCLITNQPDWGTDQAQQAILTARNNKL-----NFETQRKTAEQTLRNLLNLKP 233

Query: 238 NDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTR 278
           N+ L    P  ++V     +  G+++N   S     P    
Sbjct: 234 NEALNITFPHIMNV-----KTAGVNLNVPVSVIANRPDVKA 269


>UniRef50_Q6WI29 GTP cyclohydrolase I family protein n=1 Tax=Vibrio phage KVP40
           RepID=Q6WI29_BPKV4
          Length = 302

 Score =  282 bits (722), Expect = 9e-75,   Method: Composition-based stats.
 Identities = 99/288 (34%), Positives = 138/288 (47%), Gaps = 16/288 (5%)

Query: 1   MSSYANHQALAGLTLGKST-DYRDTYD-----ASLLQGVPRSLNRDPLGLKADNLPFHGT 54
           MS+Y    A+A   LGK   DY D  D       LL  +PR LNR   G+   N  F G 
Sbjct: 1   MSNYDQVSAIAAEHLGKKAGDYSDFVDIVEVRPDLLVPIPRELNRTDYGIT--NEDFAGF 58

Query: 55  DIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQ-----TRFNNWD 109
           D W  +E+S L  +GLP   +  V     S N++ESKS KLY NSFN      TR    D
Sbjct: 59  DTWHGFEVSALTEQGLPVSGMAKVVYPSDSPNIVESKSMKLYWNSFNMAKVAATRAEVKD 118

Query: 110 EVRQTLERDLSTCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLEN 169
            +     RDLS      + V+ +   E   QP G      +D        ++  +    +
Sbjct: 119 AIEAIASRDLSEVIGAPVQVSFFT--EKLTQPHGMTGFAELDKYVSESTVFDSESGADAD 176

Query: 170 ATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQIDR-EKLLRYLVSFRHHNEF 228
                 + +  + +  L+SNC +THQPD+G L +   G +    + L++Y+VSFR  N F
Sbjct: 177 LLQESHIKKLKVFTPNLRSNCRVTHQPDFGDLYVYMSGEKTPTVDSLMQYIVSFRKENHF 236

Query: 229 HEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPST 276
           HE+CVE I+  LL    P +L V A YTRRGG +I P R+  + +   
Sbjct: 237 HEECVEMIYKALLDKFDPTELMVTALYTRRGGWNICPARATHEELLPE 284


>UniRef50_B7RUV0 GTP cyclohydrolase I subfamily, putative n=1 Tax=marine gamma
           proteobacterium HTCC2148 RepID=B7RUV0_9GAMM
          Length = 168

 Score =  216 bits (550), Expect = 7e-55,   Method: Composition-based stats.
 Identities = 77/172 (44%), Positives = 111/172 (64%), Gaps = 4/172 (2%)

Query: 111 VRQTLERDLSTCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENA 170
           +R+TL++D+       I + L  +D +E    G  +G CIDD  I+ID+     + L+  
Sbjct: 1   MRETLKKDIENTVGASIELELLPVDAVELDG-GIPDGLCIDDLQISIDSSPPGVNLLQ-- 57

Query: 171 TCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHE 230
             GE++VEE + SHLL+S C +T QPDW ++ ++YRGR +  E LLRYL++FR H EFHE
Sbjct: 58  -AGEELVEEAVYSHLLRSLCPVTGQPDWATVYVRYRGRALTHESLLRYLIAFRKHQEFHE 116

Query: 231 QCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           QCVER++ D+ +   PE L + A YTRRGGLDINP+RS+       +R+ RQ
Sbjct: 117 QCVERMYCDIHKLVSPEFLEIQAFYTRRGGLDINPFRSSDANPIPLSRMNRQ 168


>UniRef50_B8DRK9 7-cyano-7-deazaguanine reductase n=2 Tax=Desulfovibrio
           RepID=B8DRK9_DESVM
          Length = 188

 Score =  165 bits (418), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 24/136 (17%), Positives = 50/136 (36%), Gaps = 5/136 (3%)

Query: 152 DQDITIDNYEFTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG-- 207
                  +       LE       ++    ++      S C +T QPD+ ++  +Y    
Sbjct: 39  GVKAEYPHAGPGPHILEAFPNNFPDRPYIVSIAFPEFTSLCPVTGQPDFATIVTEYIPDQ 98

Query: 208 RQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWR 267
           R ++ +    Y+ ++R+H  F E     + + +     P    V   +T RGG  ++ + 
Sbjct: 99  RCVESKSFKLYMFAYRNHQSFMETITNTVLDHMTEALDPLWCRVKGLFTPRGGTHLHVFA 158

Query: 268 SNSDFVPSTT-RLVRQ 282
                V      +VR+
Sbjct: 159 ERFKQVEEPRAAMVRE 174



 Score = 62.3 bits (150), Expect = 2e-08,   Method: Composition-based stats.
 Identities = 24/124 (19%), Positives = 42/124 (33%), Gaps = 15/124 (12%)

Query: 2   SSYANHQALAGLT--LGKSTDYRDT-YDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWT 58
           ++Y   Q   G    LG   +Y        +L+  P +    P  +      F       
Sbjct: 23  AAYTRSQDQTGHLRTLGVKAEYPHAGPGPHILEAFPNNFPDRPYIVSIAFPEFT------ 76

Query: 59  LYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERD 118
               S     G P  A    E        +ESKSFKLY+ ++   + +  + +  T+   
Sbjct: 77  ----SLCPVTGQPDFATIVTEYIPD-QRCVESKSFKLYMFAYRNHQ-SFMETITNTVLDH 130

Query: 119 LSTC 122
           ++  
Sbjct: 131 MTEA 134


>UniRef50_A9VKS1 NADPH-dependent 7-cyano-7-deazaguanine reductase n=310 Tax=Bacteria
           RepID=QUEF_BACWK
          Length = 165

 Score =  165 bits (417), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 35/111 (31%), Positives = 58/111 (52%), Gaps = 4/111 (3%)

Query: 160 YEFTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKL 215
           +E++ + LE        +            S C  T QPD+ ++ I Y    R ++ + L
Sbjct: 24  FEYSPEILEVFDNNHPNRDYFVKFNCPEFTSLCPKTGQPDFATIYISYIPEQRMVESKSL 83

Query: 216 LRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW 266
             YL SFR+H +FHE C+  I NDL++   P  + V+ ++T RGG+ I+P+
Sbjct: 84  KLYLFSFRNHGDFHEDCMNVIMNDLIKLMDPRYIEVWGKFTPRGGISIDPY 134



 Score = 73.8 bits (180), Expect = 6e-12,   Method: Composition-based stats.
 Identities = 25/108 (23%), Positives = 39/108 (36%), Gaps = 13/108 (12%)

Query: 13  LTLG-KSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLP 71
             LG ++T Y   Y   +L+    +       +K +   F           S     G P
Sbjct: 13  TLLGNQNTKYLFEYSPEILEVFDNNHPNRDYFVKFNCPEFT----------SLCPKTGQP 62

Query: 72  QVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDL 119
             A  ++        ++ESKS KLYL SF      + D +   +  DL
Sbjct: 63  DFATIYISYIPE-QRMVESKSLKLYLFSFRNHGDFHEDCM-NVIMNDL 108


>UniRef50_Q2IH01 NADPH-dependent 7-cyano-7-deazaguanine reductase n=5 Tax=Bacteria
           RepID=QUEF_ANADE
          Length = 122

 Score =  163 bits (412), Expect = 8e-39,   Method: Composition-based stats.
 Identities = 26/109 (23%), Positives = 45/109 (41%), Gaps = 2/109 (1%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHN 226
                 +  E  +        C +T QPD+ +++++Y    R ++ + L  YL SFR   
Sbjct: 13  PNPKPGRPFEIAMECPEFTCVCPMTGQPDFATIRLRYVPAERCVELKSLKLYLWSFRDEG 72

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPS 275
            FHE    RI +DL+    P  + V   +  RGG+       + +    
Sbjct: 73  TFHEAVTNRICDDLVAALAPRWIEVVGDFAVRGGIHTVVTARHGERPAG 121



 Score = 58.0 bits (139), Expect = 4e-07,   Method: Composition-based stats.
 Identities = 20/93 (21%), Positives = 27/93 (29%), Gaps = 12/93 (12%)

Query: 30  LQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIE 89
           LQ  P      P  +  +   F                 G P  A   +     +   +E
Sbjct: 9   LQTFPNPKPGRPFEIAMECPEFTCV----------CPMTGQPDFATIRLRYVP-AERCVE 57

Query: 90  SKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTC 122
            KS KLYL SF        + V   +  DL   
Sbjct: 58  LKSLKLYLWSFRD-EGTFHEAVTNRICDDLVAA 89


>UniRef50_B3E3W5 7-cyano-7-deazaguanine reductase n=3 Tax=Proteobacteria
           RepID=B3E3W5_GEOLS
          Length = 144

 Score =  162 bits (409), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 36/120 (30%), Positives = 53/120 (44%), Gaps = 2/120 (1%)

Query: 151 DDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--R 208
           D  D  +  +  +                 +        C +T QPD+G++ I Y+   R
Sbjct: 21  DAPDAGLLEWFPSPYVDPELNPCGCTGTLHISCPEFTCLCPMTGQPDFGTIIIDYQPDQR 80

Query: 209 QIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRS 268
            ++ + L  YL SFR H EFHE  V RI NDL++   P  L+V   +T RGG+   P   
Sbjct: 81  CVESKSLKLYLGSFRMHGEFHEAGVNRICNDLVKLLDPVWLTVKGEFTPRGGIPFWPTAE 140



 Score = 64.6 bits (156), Expect = 4e-09,   Method: Composition-based stats.
 Identities = 33/143 (23%), Positives = 45/143 (31%), Gaps = 11/143 (7%)

Query: 7   HQALAGLTLGKSTDYR-DTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWL 65
           H+ L  L  GK+T Y  D  DA LL+  P       L          GT   +  E + L
Sbjct: 4   HEGLKTLGEGKATTYSYDAPDAGLLEWFPSPYVDPELNPCGCT----GTLHISCPEFTCL 59

Query: 66  NA-KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQ 124
               G P      ++        +ESKS KLYL SF        +     +  DL     
Sbjct: 60  CPMTGQPDFGTIIIDYQPD-QRCVESKSLKLYLGSFRMH-GEFHEAGVNRICNDLVKLLD 117

Query: 125 G---KISVALYRLDELEGQPIGH 144
                +         +   P   
Sbjct: 118 PVWLTVKGEFTPRGGIPFWPTAE 140


>UniRef50_C7JB01 Queuosine biosynthesis protein QueF n=9 Tax=Alphaproteobacteria
           RepID=C7JB01_ACEP3
          Length = 178

 Score =  162 bits (409), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 32/111 (28%), Positives = 49/111 (44%), Gaps = 2/111 (1%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHN 226
            A   +K       +    S C IT QPD+  + I Y   +  ++ + L  YL SFR+H 
Sbjct: 55  PAPYPDKHYLVRFTAPEFTSLCPITGQPDFAHIVIDYVPDKWIVESKSLKLYLTSFRNHG 114

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTT 277
            FHE C  +I N L+    P  L + A +  RGG+ I+ +    +      
Sbjct: 115 AFHEACSIQIANTLVERLAPRWLRIGAYWYPRGGIPIDVFWQTGEPPAGVW 165



 Score = 61.5 bits (148), Expect = 3e-08,   Method: Composition-based stats.
 Identities = 22/100 (22%), Positives = 34/100 (34%), Gaps = 11/100 (11%)

Query: 15  LGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVA 74
           LGK      + + ++L+ VP         ++     F           S     G P  A
Sbjct: 36  LGKQVAAPQSPEEAILERVPAPYPDKHYLVRFTAPEFT----------SLCPITGQPDFA 85

Query: 75  VGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQT 114
              ++       ++ESKS KLYL SF      +     Q 
Sbjct: 86  HIVIDYVPDK-WIVESKSLKLYLTSFRNHGAFHEACSIQI 124


>UniRef50_Q3SJI1 NADPH-dependent 7-cyano-7-deazaguanine reductase n=9 Tax=Bacteria
           RepID=QUEF_THIDA
          Length = 139

 Score =  159 bits (403), Expect = 9e-38,   Method: Composition-based stats.
 Identities = 29/120 (24%), Positives = 46/120 (38%), Gaps = 7/120 (5%)

Query: 167 LENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSF 222
           LE        +     +        C  T QPD+ +L + Y      ++ + L  Y+ SF
Sbjct: 9   LETFPNPKPGRDFHIHMEVPEFTCLCPKTGQPDFATLVLDYIPNQACVELKSLKLYMWSF 68

Query: 223 RHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW---RSNSDFVPSTTRL 279
           R    FHE    RI +DL+    P  + + A++  RGG+  N     R +         L
Sbjct: 69  RDEGHFHEDVTNRILDDLVAATDPRYMRLTAKFYVRGGIFTNVVAEHRKDGWQPAPRVDL 128



 Score = 47.3 bits (111), Expect = 7e-04,   Method: Composition-based stats.
 Identities = 18/94 (19%), Positives = 27/94 (28%), Gaps = 12/94 (12%)

Query: 30  LQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIE 89
           L+  P         +  +   F                 G P  A   ++        +E
Sbjct: 9   LETFPNPKPGRDFHIHMEVPEFT----------CLCPKTGQPDFATLVLDYIPN-QACVE 57

Query: 90  SKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCA 123
            KS KLY+ SF      + D V   +  DL    
Sbjct: 58  LKSLKLYMWSFRDEGHFHED-VTNRILDDLVAAT 90


>UniRef50_C4XPJ6 Putative uncharacterized protein n=1 Tax=Desulfovibrio magneticus
           RS-1 RepID=C4XPJ6_DESMR
          Length = 143

 Score =  159 bits (402), Expect = 1e-37,   Method: Composition-based stats.
 Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 4/110 (3%)

Query: 163 TTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRY 218
           T   LE       ++  + T  S    S C  T QPD+G++ I+Y      I+ + L  Y
Sbjct: 28  TPGLLETFPNAFPDRRYDITFASDEFTSLCPKTGQPDFGTITIRYVPDKLCIESKSLKLY 87

Query: 219 LVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRS 268
           L S+R    F E    RI +DL+  CQP  + V   +  RGG+ I+   +
Sbjct: 88  LFSYRDEGAFMETLTNRILDDLVEVCQPHHMEVTGDFAARGGITISVTAT 137



 Score = 93.9 bits (232), Expect = 5e-18,   Method: Composition-based stats.
 Identities = 25/121 (20%), Positives = 37/121 (30%), Gaps = 15/121 (12%)

Query: 5   ANHQALAGLTLGK-STDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELS 63
            +   L    LG+ +T Y       LL+  P +       +   +  F           S
Sbjct: 8   DDVSTLKT--LGQGATVYPRNVTPGLLETFPNAFPDRRYDITFASDEFT----------S 55

Query: 64  WLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCA 123
                G P      +         IESKS KLYL S+        + +   +  DL    
Sbjct: 56  LCPKTGQPDFGTITIRYVPDK-LCIESKSLKLYLFSYRD-EGAFMETLTNRILDDLVEVC 113

Query: 124 Q 124
           Q
Sbjct: 114 Q 114


>UniRef50_Q0AAV5 NADPH-dependent 7-cyano-7-deazaguanine reductase n=11 Tax=Bacteria
           RepID=QUEF_ALHEH
          Length = 129

 Score =  158 bits (399), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 30/121 (24%), Positives = 46/121 (38%), Gaps = 7/121 (5%)

Query: 167 LENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSF 222
           LE       E+     +        C  T QPD+ ++ + Y    R ++ + L  Y+ SF
Sbjct: 9   LETFPNPRPERDFVLHMRIPEFTCLCPKTGQPDFATIHLDYVPDERCVELKSLKLYMWSF 68

Query: 223 RHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW---RSNSDFVPSTTRL 279
           R    FHE     I +DL+R  +P  + V A +  RGG+        R           L
Sbjct: 69  RDQGAFHEAITNEILDDLVRATEPRYMKVTAEFYVRGGIYTTVVAEHRKPGWAPAPKVEL 128

Query: 280 V 280
            
Sbjct: 129 A 129



 Score = 50.0 bits (118), Expect = 1e-04,   Method: Composition-based stats.
 Identities = 17/64 (26%), Positives = 26/64 (40%), Gaps = 3/64 (4%)

Query: 61  ELSWLNAK-GLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDL 119
           E + L  K G P  A  H++        +E KS KLY+ SF   +    + +   +  DL
Sbjct: 29  EFTCLCPKTGQPDFATIHLDYVPD-ERCVELKSLKLYMWSFRD-QGAFHEAITNEILDDL 86

Query: 120 STCA 123
               
Sbjct: 87  VRAT 90


>UniRef50_C7M0Q2 7-cyano-7-deazaguanine reductase n=1 Tax=Acidimicrobium
           ferrooxidans DSM 10331 RepID=C7M0Q2_ACIFD
          Length = 155

 Score =  157 bits (397), Expect = 4e-37,   Method: Composition-based stats.
 Identities = 39/127 (30%), Positives = 58/127 (45%), Gaps = 7/127 (5%)

Query: 161 EFTTDYLENATCGEKV--VEETLVSHLLKSNCLITHQPDWGSLQIQYR--GRQIDREKLL 216
           +     LE     +    +   L +    S C +T QPD+G L I Y    R ++ + L 
Sbjct: 21  DPDPSVLETFPTPQPSGGLVIRLFALEFTSLCPVTGQPDYGQLDIVYVPGPRCVESKSLK 80

Query: 217 RYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWR---SNSDFV 273
            YL+ FR+H  FHE CV ++  DL     P  L V  R+  RGG+ I P R   ++ +  
Sbjct: 81  LYLMRFRNHGAFHEACVAQVAQDLASVLAPRYLRVIGRFNARGGIAIWPLREVVADHEDP 140

Query: 274 PSTTRLV 280
            +   LV
Sbjct: 141 AALRALV 147



 Score = 68.8 bits (167), Expect = 2e-10,   Method: Composition-based stats.
 Identities = 34/172 (19%), Positives = 53/172 (30%), Gaps = 18/172 (10%)

Query: 5   ANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSW 64
            +   L  L   + T   D  D S+L+  P       L ++   L F           S 
Sbjct: 2   DDSITLQALGSSRQTYAYDDPDPSVLETFPTPQPSGGLVIRLFALEFT----------SL 51

Query: 65  LNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQ 124
               G P      +         +ESKS KLYL  F      +   V Q + +DL++   
Sbjct: 52  CPVTGQPDYGQLDIVYVP-GPRCVESKSLKLYLMRFRNHGAFHEACVAQ-VAQDLASVLA 109

Query: 125 GKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKV 176
            +    + R +   G  I        D +D            L +   G + 
Sbjct: 110 PRYLRVIGRFNARGGIAIWPLREVVADHEDPAALRA------LVDLDNGARP 155


>UniRef50_B8IYG6 NADPH-dependent 7-cyano-7-deazaguanine reductase n=6
           Tax=Desulfovibrionaceae RepID=QUEF_DESDA
          Length = 167

 Score =  156 bits (395), Expect = 8e-37,   Method: Composition-based stats.
 Identities = 28/134 (20%), Positives = 51/134 (38%), Gaps = 6/134 (4%)

Query: 155 ITIDNYEFTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QI 210
           +T      +   LE       ++    ++      S C +T QPD G++ ++Y      +
Sbjct: 20  LTSPEGGPSVALLEAFPNCFPQRPYVISISFPEFTSLCPVTGQPDCGTITVEYIPDELCV 79

Query: 211 DREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNS 270
           + +    Y+ +FR+H  F E     +  DL     P    V   +  RGG  I+ +    
Sbjct: 80  ESKSFKLYMFAFRNHQSFMETITNNVLEDLRALLNPCWCRVKGLFAPRGGTRIHVFAEAF 139

Query: 271 D--FVPSTTRLVRQ 282
                   + LVR+
Sbjct: 140 KDGMPEEQSALVRE 153



 Score = 58.8 bits (141), Expect = 2e-07,   Method: Composition-based stats.
 Identities = 26/119 (21%), Positives = 40/119 (33%), Gaps = 12/119 (10%)

Query: 3   SYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYEL 62
           S    + L  L  G+ T        +LL+  P    + P  +      F           
Sbjct: 5   SQDQTRDLKVLGTGRLTSPEGGPSVALLEAFPNCFPQRPYVISISFPEFT---------- 54

Query: 63  SWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLST 121
           S     G P      VE        +ESKSFKLY+ +F   + +  + +   +  DL  
Sbjct: 55  SLCPVTGQPDCGTITVEYIPD-ELCVESKSFKLYMFAFRNHQ-SFMETITNNVLEDLRA 111


>UniRef50_Q9ZJJ9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=12
           Tax=Helicobacter RepID=QUEF_HELPJ
          Length = 148

 Score =  154 bits (389), Expect = 4e-36,   Method: Composition-based stats.
 Identities = 38/111 (34%), Positives = 60/111 (54%), Gaps = 4/111 (3%)

Query: 160 YEFTTDYLENATCGEKVVE--ETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKL 215
           +E+ +D LE        ++   TL      S C IT QPD+G + I+Y  +   ++ + L
Sbjct: 18  FEYNSDLLEAFPNPNPNLDPLITLECKEFTSLCPITSQPDFGVIFIRYIPKDKMVESKSL 77

Query: 216 LRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW 266
             YL S+R+H  FHE C+  I  DL++  +P+ L VY  +  RGG+ I P+
Sbjct: 78  KLYLFSYRNHGSFHESCINTILLDLVQLLEPKYLEVYGDFVSRGGIAIKPF 128



 Score = 66.9 bits (162), Expect = 8e-10,   Method: Composition-based stats.
 Identities = 24/107 (22%), Positives = 36/107 (33%), Gaps = 12/107 (11%)

Query: 15  LGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVA 74
           LG  T Y   Y++ LL+  P         +  +   F           S       P   
Sbjct: 10  LGAKTPYIFEYNSDLLEAFPNPNPNLDPLITLECKEFT----------SLCPITSQPDFG 59

Query: 75  VGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLST 121
           V  +        ++ESKS KLYL S+      +   +  T+  DL  
Sbjct: 60  VIFIRYIP-KDKMVESKSLKLYLFSYRNHGSFHESCI-NTILLDLVQ 104


>UniRef50_D2L9R9 7-cyano-7-deazaguanine reductase n=1 Tax=Desulfovibrio sp. FW1012B
           RepID=D2L9R9_9DELT
          Length = 145

 Score =  153 bits (388), Expect = 5e-36,   Method: Composition-based stats.
 Identities = 35/109 (32%), Positives = 49/109 (44%), Gaps = 4/109 (3%)

Query: 163 TTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRY 218
           T   LE        +    T  S    S C  T QPD+G + I+Y    R I+ + L  Y
Sbjct: 32  TPGLLETFPNAFPGRRYTVTFASEEFTSLCPKTGQPDFGMITIRYVPDERCIESKSLKLY 91

Query: 219 LVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWR 267
           L S+R    F E    RI +DL+  CQP ++ V   +  RGG+ I+   
Sbjct: 92  LFSYRDEGTFMETLTNRILDDLVAACQPLEMEVTGDFAARGGITISVTA 140



 Score =  105 bits (261), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 29/145 (20%), Positives = 45/145 (31%), Gaps = 17/145 (11%)

Query: 5   ANHQALAGLTLGK-STDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELS 63
            +   L    LG+ +T Y  T    LL+  P +       +   +  F           S
Sbjct: 12  DDVSTLTT--LGQGATAYPRTVTPGLLETFPNAFPGRRYTVTFASEEFT----------S 59

Query: 64  WLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCA 123
                G P   +  +         IESKS KLYL S+        + +   +  DL    
Sbjct: 60  LCPKTGQPDFGMITIRYVPD-ERCIESKSLKLYLFSYRD-EGTFMETLTNRILDDLVAAC 117

Query: 124 QGKISVALY-RLDELEGQPIGHFNG 147
           Q  + + +        G  I    G
Sbjct: 118 Q-PLEMEVTGDFAARGGITISVTAG 141


>UniRef50_Q8GJN6 NADPH-dependent 7-cyano-7-deazaguanine reductase n=98 Tax=cellular
           organisms RepID=QUEF_SYNE7
          Length = 174

 Score =  153 bits (387), Expect = 5e-36,   Method: Composition-based stats.
 Identities = 31/120 (25%), Positives = 48/120 (40%), Gaps = 4/120 (3%)

Query: 162 FTTDYLENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLR 217
                LE       ++      V+    S C +T QPD+  L + Y   Q  ++ + L  
Sbjct: 42  PEVAVLETFDNPHPDRQYLVRFVAPEFTSLCPLTGQPDFAHLVLDYVPDQRLVESKSLKL 101

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTT 277
           +L SFR+H  FHE C   I   L     P  L +   +  RGGL I+ +  + +      
Sbjct: 102 FLGSFRNHGAFHENCTLTIAKRLEEAMNPTWLRLGGYWYPRGGLPIDVFYQSGEPPAGVW 161



 Score = 59.6 bits (143), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 21/122 (17%), Positives = 37/122 (30%), Gaps = 12/122 (9%)

Query: 3   SYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYEL 62
           S           LG+      + + ++L+            ++     F           
Sbjct: 20  SLQKFMTETLTQLGQMVGLPASPEVAVLETFDNPHPDRQYLVRFVAPEFT---------- 69

Query: 63  SWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTC 122
           S     G P  A   ++       L+ESKS KL+L SF      + +    T+ + L   
Sbjct: 70  SLCPLTGQPDFAHLVLDYVPD-QRLVESKSLKLFLGSFRNHGAFHENCTL-TIAKRLEEA 127

Query: 123 AQ 124
             
Sbjct: 128 MN 129


>UniRef50_Q8UD54 NADPH-dependent 7-cyano-7-deazaguanine reductase n=45
           Tax=Alphaproteobacteria RepID=QUEF_AGRT5
          Length = 154

 Score =  153 bits (387), Expect = 6e-36,   Method: Composition-based stats.
 Identities = 31/120 (25%), Positives = 47/120 (39%), Gaps = 4/120 (3%)

Query: 162 FTTDYLENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLR 217
                LE    G           +    S C +T QPD+  + I Y      ++ + L  
Sbjct: 22  PEKAVLEKVPNGNAGTDYVVRFTAPEFTSLCPMTGQPDFAHIVIDYIPGDFLVESKSLKL 81

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTT 277
           +L SFR+H  FHE C   I   L+   QP+ L + A +  RGG+ I+ +           
Sbjct: 82  FLQSFRNHGAFHEDCSVYIAKRLVELLQPKWLRIGAYWYPRGGIPIDVFWQTGAAPEGVW 141



 Score = 63.4 bits (153), Expect = 9e-09,   Method: Composition-based stats.
 Identities = 31/150 (20%), Positives = 49/150 (32%), Gaps = 24/150 (16%)

Query: 3   SYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYEL 62
           S  +   L+   LG   D  ++ + ++L+ VP         ++     F           
Sbjct: 2   SVTDVSGLSQ--LGTKVDTPESPEKAVLEKVPNGNAGTDYVVRFTAPEFT---------- 49

Query: 63  SWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTC 122
           S     G P  A   ++       L+ESKS KL+L SF      + D      +R     
Sbjct: 50  SLCPMTGQPDFAHIVIDYIP-GDFLVESKSLKLFLQSFRNHGAFHEDCSVYIAKR----- 103

Query: 123 AQGKISVALYRLDELEGQPIGHFN-GTCID 151
                 V L +   L      +   G  ID
Sbjct: 104 -----LVELLQPKWLRIGAYWYPRGGIPID 128


>UniRef50_Q6MRJ2 NADPH-dependent 7-cyano-7-deazaguanine reductase n=1
           Tax=Bdellovibrio bacteriovorus RepID=QUEF_BDEBA
          Length = 170

 Score =  152 bits (383), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 36/110 (32%), Positives = 57/110 (51%), Gaps = 4/110 (3%)

Query: 162 FTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLR 217
           +  + LE        K+   T V     S C  T QPD+  + I Y   +  ++ + L  
Sbjct: 28  YAPEVLEAFDNKNPGKIAWTTFVCTEFTSLCPKTRQPDFAKIFINYIADKKMVESKSLKL 87

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWR 267
           YL SFR+H +FHE CV+ I +DL++  +P+ + V   +T RGG+ I P+ 
Sbjct: 88  YLFSFRNHGDFHEDCVQTICDDLVKLMKPKYIEVIGEFTPRGGIAIYPYA 137



 Score = 96.6 bits (239), Expect = 8e-19,   Method: Composition-based stats.
 Identities = 35/129 (27%), Positives = 54/129 (41%), Gaps = 21/129 (16%)

Query: 3   SYANHQALAGLTLGKS-TDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLY- 60
           +  + + LA   LG+S T+Y +TY   +L+                     G   WT + 
Sbjct: 5   NGRDSKELADFALGESQTNYPETYAPEVLEAFDNKNP--------------GKIAWTTFV 50

Query: 61  --ELSWLNAKGLPQVAVGHVELDYTSVN-LIESKSFKLYLNSFNQTRFNNWDEVRQTLER 117
             E + L  K   Q     + ++Y +   ++ESKS KLYL SF      + D V QT+  
Sbjct: 51  CTEFTSLCPKTR-QPDFAKIFINYIADKKMVESKSLKLYLFSFRNHGDFHEDCV-QTICD 108

Query: 118 DLSTCAQGK 126
           DL    + K
Sbjct: 109 DLVKLMKPK 117


>UniRef50_A6C8E2 Putative uncharacterized protein n=2 Tax=Planctomycetaceae
           RepID=A6C8E2_9PLAN
          Length = 121

 Score =  152 bits (383), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 32/120 (26%), Positives = 51/120 (42%), Gaps = 4/120 (3%)

Query: 158 DNYEFTTDYLENATCGE--KVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQI--DRE 213
              E + + LE        +      V     S C  T QPD+G+L I Y   ++  + +
Sbjct: 2   SENEASRELLETFENPHPHRDYVMETVCPEFTSVCPKTGQPDYGTLIITYIPDKVCFELK 61

Query: 214 KLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFV 273
            L  YL S+R+   F+E    RI +DL+    P  + + A +T RGG+      S+    
Sbjct: 62  SLKMYLQSYRNVGAFYEDVTNRILDDLVAITDPRWMELRAEFTPRGGISSTVTVSHHKED 121



 Score = 43.4 bits (101), Expect = 0.008,   Method: Composition-based stats.
 Identities = 18/98 (18%), Positives = 25/98 (25%), Gaps = 12/98 (12%)

Query: 26  DASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSV 85
              LL+            ++     F           S     G P      +      V
Sbjct: 7   SRELLETFENPHPHRDYVMETVCPEFT----------SVCPKTGQPDYGTLIITYIPDKV 56

Query: 86  NLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCA 123
              E KS K+YL S+        D V   +  DL    
Sbjct: 57  -CFELKSLKMYLQSYRNVGAFYED-VTNRILDDLVAIT 92


>UniRef50_A1WY83 NADPH-dependent 7-cyano-7-deazaguanine reductase n=5 Tax=Bacteria
           RepID=QUEF_HALHL
          Length = 118

 Score =  151 bits (382), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 24/104 (23%), Positives = 42/104 (40%), Gaps = 2/104 (1%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRHHN 226
                E+     +        C  T QPD+ +L ++Y      ++ + L  Y+ S+R   
Sbjct: 13  ENPNPERDYTIRMEIPEFTCLCPKTGQPDFATLNLEYIPERHCVELKSLKLYIWSYRDVG 72

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNS 270
            FHE    +I  DL+   QP  + + A +  RGG+       + 
Sbjct: 73  GFHEALTNQILGDLVAATQPRYMKLTAHFNVRGGIWTTVEAEHH 116



 Score = 45.7 bits (107), Expect = 0.002,   Method: Composition-based stats.
 Identities = 16/95 (16%), Positives = 30/95 (31%), Gaps = 12/95 (12%)

Query: 30  LQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIE 89
           L+            ++ +   F                 G P  A  ++E      + +E
Sbjct: 9   LETFENPNPERDYTIRMEIPEFT----------CLCPKTGQPDFATLNLEYIPER-HCVE 57

Query: 90  SKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQ 124
            KS KLY+ S+      + + +   +  DL    Q
Sbjct: 58  LKSLKLYIWSYRDVGGFH-EALTNQILGDLVAATQ 91


>UniRef50_Q2LTJ0 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2 Tax=Bacteria
           RepID=QUEF_SYNAS
          Length = 140

 Score =  149 bits (377), Expect = 1e-34,   Method: Composition-based stats.
 Identities = 28/103 (27%), Positives = 43/103 (41%), Gaps = 4/103 (3%)

Query: 167 LENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSF 222
           LE       ++    T+ +      C +T QPD+  L I Y      ++ + L  YL S+
Sbjct: 26  LETFPNRHPDRDYIVTMETAEFTCVCPMTGQPDFADLHISYIPDASILESKSLKLYLWSY 85

Query: 223 RHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINP 265
           R+   FHE     I  D++    P    V A +  RGG+ I  
Sbjct: 86  RNEGIFHEHVTNVILEDVVAALSPRWCKVTANFGVRGGISITV 128



 Score = 52.7 bits (125), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 18/93 (19%), Positives = 30/93 (32%), Gaps = 12/93 (12%)

Query: 30  LQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIE 89
           L+  P         +  +   F                 G P  A  H+     + +++E
Sbjct: 26  LETFPNRHPDRDYIVTMETAEFTCV----------CPMTGQPDFADLHISYIPDA-SILE 74

Query: 90  SKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTC 122
           SKS KLYL S+      +   V   +  D+   
Sbjct: 75  SKSLKLYLWSYRNEGIFHEH-VTNVILEDVVAA 106


>UniRef50_D1N404 7-cyano-7-deazaguanine reductase n=3 Tax=Bacteria
           RepID=D1N404_9BACT
          Length = 142

 Score =  146 bits (369), Expect = 7e-34,   Method: Composition-based stats.
 Identities = 33/109 (30%), Positives = 50/109 (45%), Gaps = 4/109 (3%)

Query: 161 EFTTDYLENA--TCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLL 216
                 LE       ++            S C +T QPD+G + ++Y      I+ + L 
Sbjct: 25  RPEEARLEAFRNVYADRDYIIEFDCPEYTSLCPVTGQPDFGHIILRYVPDKLCIESKSLK 84

Query: 217 RYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINP 265
            YL SFR+ N FHE+ V  I + +++ C P K  V  R+  RGG+ IN 
Sbjct: 85  LYLYSFRNTNTFHEESVNTILDAVVKTCAPRKAEVIGRFRPRGGIAINV 133



 Score = 60.0 bits (144), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 23/121 (19%), Positives = 39/121 (32%), Gaps = 13/121 (10%)

Query: 20  DYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVE 79
           +Y    + + L+            ++ D   +           S     G P      + 
Sbjct: 21  NYPTRPEEARLEAFRNVYADRDYIIEFDCPEYT----------SLCPVTGQPDFGHIILR 70

Query: 80  LDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCA--QGKISVALYRLDEL 137
                   IESKS KLYL SF  T   + + V   L+  + TCA  + ++         +
Sbjct: 71  YVPDK-LCIESKSLKLYLYSFRNTNTFHEESVNTILDAVVKTCAPRKAEVIGRFRPRGGI 129

Query: 138 E 138
            
Sbjct: 130 A 130


>UniRef50_B2UN89 7-cyano-7-deazaguanine reductase n=2 Tax=Verrucomicrobiaceae
           RepID=B2UN89_AKKM8
          Length = 136

 Score =  146 bits (369), Expect = 7e-34,   Method: Composition-based stats.
 Identities = 36/122 (29%), Positives = 58/122 (47%), Gaps = 6/122 (4%)

Query: 161 EFTTDYLENATC-GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLR 217
                 LE+    G +    TL +H   S C +T QPD   L I Y    + ++ + L  
Sbjct: 18  NPDDARLESFPNRGTRPYTITLDTHEFSSLCPVTGQPDSCHLTITYVPAEKCVETKSLKY 77

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTT 277
           YL ++R++  F+EQ V RI +DL+    P  L V  R++ RGG+ +    + ++  P   
Sbjct: 78  YLAAYRNYPAFNEQIVNRITDDLVAAISPRWLKVEGRFSPRGGIQLT---ATAEHNPENR 134

Query: 278 RL 279
            L
Sbjct: 135 PL 136



 Score = 54.6 bits (130), Expect = 4e-06,   Method: Composition-based stats.
 Identities = 24/143 (16%), Positives = 41/143 (28%), Gaps = 20/143 (13%)

Query: 5   ANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSW 64
            +H  L    LG  + +    D + L+  P    R P  +  D   F           S 
Sbjct: 3   DDHLTL----LGSQSSFFTNPDDARLESFPNRGTR-PYTITLDTHEFS----------SL 47

Query: 65  LNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQ 124
               G P      +     +   +E+KS K YL ++      N   +   +  DL     
Sbjct: 48  CPVTGQPDSCHLTITYVP-AEKCVETKSLKYYLAAYRNYPAFNEQ-IVNRITDDLVAAIS 105

Query: 125 G---KISVALYRLDELEGQPIGH 144
               K+         ++      
Sbjct: 106 PRWLKVEGRFSPRGGIQLTATAE 128


>UniRef50_B3QM19 NADPH-dependent 7-cyano-7-deazaguanine reductase n=4 Tax=Bacteria
           RepID=QUEF_CHLP8
          Length = 116

 Score =  144 bits (363), Expect = 4e-33,   Method: Composition-based stats.
 Identities = 27/111 (24%), Positives = 47/111 (42%), Gaps = 4/111 (3%)

Query: 162 FTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLR 217
              + +E        +     +V+    S C  T  PD+G++ I Y      I+ + L  
Sbjct: 1   MNKEIIEVFDNTFPNRDYTIEIVNPEFTSVCPKTGLPDFGTITITYVPDKSCIELKSLKY 60

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRS 268
           Y + FR+   F+E     I + L+  CQP+ ++V   +  RGG+      S
Sbjct: 61  YFLEFRNAGIFYENITNTILDHLVEACQPKSMTVKTDWNARGGITETVTVS 111



 Score = 45.7 bits (107), Expect = 0.002,   Method: Composition-based stats.
 Identities = 17/99 (17%), Positives = 28/99 (28%), Gaps = 12/99 (12%)

Query: 28  SLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNL 87
            +++    +       ++  N  F           S     GLP      +       + 
Sbjct: 4   EIIEVFDNTFPNRDYTIEIVNPEFT----------SVCPKTGLPDFGTITITYVPDK-SC 52

Query: 88  IESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGK 126
           IE KS K Y   F        + +  T+   L    Q K
Sbjct: 53  IELKSLKYYFLEFRNAGIFYEN-ITNTILDHLVEACQPK 90


>UniRef50_A8ZUH0 GTP cyclohydrolase I n=2 Tax=Desulfobacteraceae RepID=A8ZUH0_DESOH
          Length = 134

 Score =  142 bits (359), Expect = 1e-32,   Method: Composition-based stats.
 Identities = 30/109 (27%), Positives = 51/109 (46%), Gaps = 2/109 (1%)

Query: 166 YLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFR 223
            +E A    + ++  +      S C +T  PD+G + I+YR R   ++ + L  YL+ +R
Sbjct: 26  VIEYAYRETRPIDVVIRQPEFTSLCPMTGLPDYGCITIRYRPRHHIVELKSLKYYLLQYR 85

Query: 224 HHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDF 272
           +   F+E  + RI NDL     P  + V   +T RGG+      +  D 
Sbjct: 86  NVGIFYEHVINRILNDLSGAVAPVWMEVSGEFTARGGITTTVTAATGDQ 134


>UniRef50_D2REX4 GTP cyclohydrolase I n=1 Tax=Archaeoglobus profundus DSM 5631
           RepID=D2REX4_ARCPR
          Length = 236

 Score =  142 bits (358), Expect = 1e-32,   Method: Composition-based stats.
 Identities = 35/182 (19%), Positives = 63/182 (34%), Gaps = 26/182 (14%)

Query: 106 NNWDEVRQTLERDLSTCAQGKISVALY---RLDELEGQPIGHFNGTCIDDQDITIDNYEF 162
           +N +  R+ + RDL  C +  + V +        +    I    G  +           +
Sbjct: 47  DNEELCREIVTRDLELCEKADVIVLVAKHPSFGAMAEVVISAMKGKPVVAFCPEKVRSPW 106

Query: 163 TTDY--------------LENATCGEKVVEETLVSHL-------LKSNCLITHQPDWGSL 201
              +              L+      + +      H            C +T   D G++
Sbjct: 107 PIYFANKVVRSEEELVRALKELETPLRTIPNVYSDHEAEFTYTKFTCICPVTGLRDIGTI 166

Query: 202 QIQYRG--RQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRG 259
           +I+Y+   R ++ E L  Y   F      HE  V ++FND+ +   PE L V A +  R 
Sbjct: 167 KIRYKPKDRILEYESLDSYFKLFADKKMHHEAVVCKVFNDIYQALNPEWLEVVAEFEERS 226

Query: 260 GL 261
           G+
Sbjct: 227 GV 228


>UniRef50_B3EMR0 NADPH-dependent 7-cyano-7-deazaguanine reductase n=9 Tax=Bacteria
           RepID=QUEF_CHLPB
          Length = 118

 Score =  142 bits (357), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 27/111 (24%), Positives = 48/111 (43%), Gaps = 4/111 (3%)

Query: 162 FTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLR 217
              + LE       ++     +V+    S C IT  PD+G++ I+Y      ++ + L  
Sbjct: 1   MQKELLEVFDNRFPDRDYTIEIVNPEFTSVCPITGLPDFGTITIRYIPDKVCVELKSLKY 60

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRS 268
           Y + FR+   F+E     I + L+   +P  L+V   +  RGG+      S
Sbjct: 61  YYLEFRNAGIFYENVTNTILDHLVDLLKPRTLTVTTAWKARGGITETVTVS 111



 Score = 40.7 bits (94), Expect = 0.063,   Method: Composition-based stats.
 Identities = 18/92 (19%), Positives = 25/92 (27%), Gaps = 12/92 (13%)

Query: 28  SLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNL 87
            LL+            ++  N  F           S     GLP      +      V  
Sbjct: 4   ELLEVFDNRFPDRDYTIEIVNPEFT----------SVCPITGLPDFGTITIRYIPDKV-C 52

Query: 88  IESKSFKLYLNSFNQTRFNNWDEVRQTLERDL 119
           +E KS K Y   F        + V  T+   L
Sbjct: 53  VELKSLKYYYLEFRNAGIFYEN-VTNTILDHL 83


>UniRef50_B7J648 NADPH-dependent 7-cyano-7-deazaguanine reductase n=22 Tax=Bacteria
           RepID=QUEF_ACIF2
          Length = 141

 Score =  142 bits (357), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 28/111 (25%), Positives = 43/111 (38%), Gaps = 5/111 (4%)

Query: 170 ATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNE 227
               E+     +        C +T QPD+    + +   Q  ++ + L  YL SFR    
Sbjct: 14  NPHPERDYVVHMDLPEFTCLCPLTGQPDFAHFMLDFIPDQHNVELKSLKLYLWSFRDEGA 73

Query: 228 FHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW---RSNSDFVPS 275
           FHE    RI +DL+    P  L +  R+  RGG+  +     R      P 
Sbjct: 74  FHEAMTNRIADDLIGLINPRYLRLLGRWYVRGGITTDVLIEHRQPGWQNPD 124



 Score = 44.2 bits (103), Expect = 0.005,   Method: Composition-based stats.
 Identities = 17/60 (28%), Positives = 24/60 (40%), Gaps = 3/60 (5%)

Query: 61  ELSWLNA-KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDL 119
           E + L    G P  A   ++      N +E KS KLYL SF        + +   +  DL
Sbjct: 29  EFTCLCPLTGQPDFAHFMLDFIPDQHN-VELKSLKLYLWSFRD-EGAFHEAMTNRIADDL 86


>UniRef50_Q04RM8 NADPH-dependent 7-cyano-7-deazaguanine reductase n=6 Tax=Leptospira
           RepID=QUEF_LEPBJ
          Length = 133

 Score =  141 bits (356), Expect = 3e-32,   Method: Composition-based stats.
 Identities = 27/102 (26%), Positives = 41/102 (40%), Gaps = 2/102 (1%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHN 226
                 K            + C  T  PD+G + + Y    R I+ +    Y++S+R+  
Sbjct: 28  TNVYEGKDYTIDFTVPEFTAVCPKTGLPDFGVIYVSYVPTKRCIELKSFKEYILSYRNVG 87

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRS 268
            FHE  V +I  DL+    P+ L V   Y  RGG+     R 
Sbjct: 88  VFHEFLVNKIMEDLIAAIDPKYLKVIGDYNARGGIKTVVTRE 129



 Score = 48.0 bits (113), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 26/119 (21%), Positives = 38/119 (31%), Gaps = 22/119 (18%)

Query: 18  STDYRDTYD------ASL----LQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNA 67
            T++ +TYD       SL    ++            +      F                
Sbjct: 2   KTNHPETYDGRQDHIPSLKTPEIESFTNVYEGKDYTIDFTVPEFTAV----------CPK 51

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGK 126
            GLP   V +V    T    IE KSFK Y+ S+      +   V + +E DL      K
Sbjct: 52  TGLPDFGVIYVSYVPTK-RCIELKSFKEYILSYRNVGVFHEFLVNKIME-DLIAAIDPK 108


>UniRef50_C0GIY6 7-cyano-7-deazaguanine reductase n=1 Tax=Dethiobacter alkaliphilus
           AHT 1 RepID=C0GIY6_9FIRM
          Length = 130

 Score =  139 bits (351), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 33/114 (28%), Positives = 45/114 (39%), Gaps = 2/114 (1%)

Query: 159 NYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLL 216
           N       LE       V    L S  + S C +T QPDW ++ I+Y      I+ + L 
Sbjct: 11  NVPEPRRKLEVFEKPAGVDRVVLESDEVTSLCPVTGQPDWETVIIEYEPDRYCIESKSLK 70

Query: 217 RYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNS 270
            Y  SFR    F E    +I ND+   C+P    V      RGG+ I    +  
Sbjct: 71  LYFWSFRQEGVFCEGLAAQIANDVHAACKPFFCKVTVIQKPRGGITITASATAG 124



 Score = 46.1 bits (108), Expect = 0.001,   Method: Composition-based stats.
 Identities = 18/70 (25%), Positives = 27/70 (38%), Gaps = 5/70 (7%)

Query: 63  SWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTC 122
           S     G P      +E +      IESKS KLY  SF Q      + +   +  D+   
Sbjct: 40  SLCPVTGQPDWETVIIEYEPDR-YCIESKSLKLYFWSFRQ-EGVFCEGLAAQIANDVHAA 97

Query: 123 AQG---KISV 129
            +    K++V
Sbjct: 98  CKPFFCKVTV 107


>UniRef50_Q8DNP8 NADPH-dependent 7-cyano-7-deazaguanine reductase n=26
           Tax=Streptococcus pneumoniae RepID=QUEF_STRR6
          Length = 154

 Score =  139 bits (350), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 36/123 (29%), Positives = 62/123 (50%), Gaps = 5/123 (4%)

Query: 155 ITIDNYEFTTDY-LENATCGEKVVEETLVSHLLKSNCL--ITHQPDWGSLQIQYRGR--Q 209
           +    + +   + LE     E   E+ +  H+L  + L  IT QPD+ ++ I Y      
Sbjct: 7   VEAVTFAYGQHHHLEIQITREIAKEQGIRHHILDMSLLGQITAQPDFATIHISYIPDKLC 66

Query: 210 IDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSN 269
           ++ + L  YL S+R+H +FHE C+  I  DL+    P  L V+ ++T RGG+ I+P+ + 
Sbjct: 67  VESKSLKLYLFSYRNHGDFHENCINTIGKDLVNLLDPRYLEVWGKFTPRGGISIDPYYNY 126

Query: 270 SDF 272
              
Sbjct: 127 GKQ 129



 Score = 54.6 bits (130), Expect = 4e-06,   Method: Composition-based stats.
 Identities = 22/91 (24%), Positives = 33/91 (36%), Gaps = 12/91 (13%)

Query: 58  TLYELSWLNA-KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLE 116
            + ++S L      P  A  H+         +ESKS KLYL S+      + + +  T+ 
Sbjct: 37  HILDMSLLGQITAQPDFATIHISYIPDK-LCVESKSLKLYLFSYRNHGDFHENCI-NTIG 94

Query: 117 RDLSTCAQGKISVALYRLDELEGQPIGHFNG 147
           +DL         V L     LE        G
Sbjct: 95  KDL---------VNLLDPRYLEVWGKFTPRG 116


>UniRef50_Q8DMA3 NADPH-dependent 7-cyano-7-deazaguanine reductase n=14 Tax=Bacteria
           RepID=QUEF_THEEB
          Length = 132

 Score =  137 bits (346), Expect = 3e-31,   Method: Composition-based stats.
 Identities = 17/106 (16%), Positives = 40/106 (37%), Gaps = 2/106 (1%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHN 226
                 +     +        C  +  PD+ +L + Y    + ++ + +  Y+ S+R   
Sbjct: 22  PNPRPGRQYTIEITLPEFTCKCPFSGYPDFATLYVSYIPHEKVVELKAIKLYINSYRDRY 81

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDF 272
             HE+ V ++ +DL+  C P  + +   +  RG +       +   
Sbjct: 82  ISHEEAVNQVLDDLVAACDPLYMKIKGDFAPRGNVHTVITVEHHRQ 127



 Score = 43.4 bits (101), Expect = 0.008,   Method: Composition-based stats.
 Identities = 19/96 (19%), Positives = 30/96 (31%), Gaps = 12/96 (12%)

Query: 28  SLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNL 87
             L   P         ++     F                 G P  A  +V        +
Sbjct: 16  GQLITFPNPRPGRQYTIEITLPEFTCK----------CPFSGYPDFATLYVSYIPH-EKV 64

Query: 88  IESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCA 123
           +E K+ KLY+NS+     ++ + V Q L  DL    
Sbjct: 65  VELKAIKLYINSYRDRYISHEEAVNQVL-DDLVAAC 99


>UniRef50_Q2J7K4 NADPH-dependent 7-cyano-7-deazaguanine reductase n=4
           Tax=Actinomycetales RepID=QUEF_FRASC
          Length = 125

 Score =  136 bits (343), Expect = 7e-31,   Method: Composition-based stats.
 Identities = 31/99 (31%), Positives = 47/99 (47%), Gaps = 2/99 (2%)

Query: 167 LENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRH 224
           LE     +   E  +        C IT QPDW +++I YR   R ++ + L  YL +FR 
Sbjct: 17  LETFPIDDTSQEIRIDCREFTCRCPITGQPDWATIRIDYRPGGRGLETKSLKLYLETFRE 76

Query: 225 HNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDI 263
              FHE     I +DL+    P +L+V   +  RGG+ +
Sbjct: 77  EGIFHEHLATLIRDDLVAALAPVQLTVTVNFNARGGIAL 115



 Score = 40.3 bits (93), Expect = 0.079,   Method: Composition-based stats.
 Identities = 13/67 (19%), Positives = 25/67 (37%), Gaps = 3/67 (4%)

Query: 65  LNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQ 124
               G P  A   ++        +E+KS KLYL +F +    +   +   +  DL     
Sbjct: 40  CPITGQPDWATIRIDYRPGG-RGLETKSLKLYLETFREEGIFHEH-LATLIRDDLVAAL- 96

Query: 125 GKISVAL 131
             + + +
Sbjct: 97  APVQLTV 103


>UniRef50_B2KDU6 NADPH-dependent 7-cyano-7-deazaguanine reductase n=4 Tax=Bacteria
           RepID=QUEF_ELUMP
          Length = 132

 Score =  136 bits (343), Expect = 9e-31,   Method: Composition-based stats.
 Identities = 25/89 (28%), Positives = 43/89 (48%), Gaps = 2/89 (2%)

Query: 175 KVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRHHNEFHEQC 232
           +  +  +      S C  T  PD+G + I Y      ++ + L  YL+ +R    F E  
Sbjct: 33  RDYDIRIELPEFTSVCPKTGLPDFGVITIDYIPDRLCLELKSLKYYLLEYRDMGIFMENI 92

Query: 233 VERIFNDLLRFCQPEKLSVYARYTRRGGL 261
             +I +D+++ C+P+K  V   +T RGGL
Sbjct: 93  ANKILDDVVKACKPKKAVVTGDFTPRGGL 121


>UniRef50_B8HRW7 7-cyano-7-deazaguanine reductase n=2 Tax=Cyanobacteria
           RepID=B8HRW7_CYAP4
          Length = 142

 Score =  136 bits (342), Expect = 1e-30,   Method: Composition-based stats.
 Identities = 20/97 (20%), Positives = 41/97 (42%), Gaps = 2/97 (2%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHN 226
                 +     +        C  +  PD+ ++ + Y   Q  ++ + +  Y+ S+R   
Sbjct: 37  PNPRPGRRYTIQITLPEFTCKCPFSGYPDFATIHVSYIPDQRVVELKAIKLYINSYRDRY 96

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDI 263
             HE+ V +I +DL+  C P ++SV   +  RG +  
Sbjct: 97  ISHEESVNQILDDLVTACDPLQISVKGDFAPRGNVHT 133



 Score = 48.4 bits (114), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 22/103 (21%), Positives = 36/103 (34%), Gaps = 11/103 (10%)

Query: 28  SLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNL 87
             L   P         ++     F                 G P  A  HV        +
Sbjct: 31  GQLITFPNPRPGRRYTIQITLPEFTCK----------CPFSGYPDFATIHVSYIPD-QRV 79

Query: 88  IESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVA 130
           +E K+ KLY+NS+     ++ + V Q L+  ++ C   +ISV 
Sbjct: 80  VELKAIKLYINSYRDRYISHEESVNQILDDLVTACDPLQISVK 122


>UniRef50_A6Q0W4 NADPH-dependent 7-cyano-7-deazaguanine reductase n=6 Tax=Bacteria
           RepID=QUEF_NITSB
          Length = 131

 Score =  135 bits (341), Expect = 1e-30,   Method: Composition-based stats.
 Identities = 22/112 (19%), Positives = 45/112 (40%), Gaps = 2/112 (1%)

Query: 154 DITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--ID 211
           +  I  ++   D         K  +  +        C  +  PD+ ++ ++Y   Q  ++
Sbjct: 5   EKEIQEFDPKKDLEIWPNKHNKPYKIKITLPEFSCLCPRSGYPDYATMHLEYIPDQYVVE 64

Query: 212 REKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDI 263
            + L  Y+ SFR+    HE     IF+ L    +P+ + + A +  RG +  
Sbjct: 65  LKALKLYINSFRNRYISHEDSTNEIFDTLYSKLKPKYMRLVADFNPRGNVHT 116



 Score = 43.8 bits (102), Expect = 0.007,   Method: Composition-based stats.
 Identities = 19/58 (32%), Positives = 28/58 (48%), Gaps = 2/58 (3%)

Query: 58  TLYELSWLNAK-GLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQT 114
           TL E S L  + G P  A  H+E       ++E K+ KLY+NSF     ++ D   + 
Sbjct: 33  TLPEFSCLCPRSGYPDYATMHLEYIPD-QYVVELKALKLYINSFRNRYISHEDSTNEI 89


>UniRef50_B5IMF1 7-cyano-7-deazaguanine reductase n=1 Tax=Cyanobium sp. PCC 7001
           RepID=B5IMF1_9CHRO
          Length = 154

 Score =  133 bits (336), Expect = 5e-30,   Method: Composition-based stats.
 Identities = 25/109 (22%), Positives = 48/109 (44%), Gaps = 2/109 (1%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHN 226
                 +V E ++        C  +  PD+ +LQ+ Y+   R ++ + +  Y+ S+R   
Sbjct: 46  ENPRPGRVYEISITLPEFTCLCPFSGYPDFATLQLLYQPGPRVMELKAIKLYVNSYRDRT 105

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPS 275
             HE+ V R+ +D +  C P  + + A +  RG +      S+    PS
Sbjct: 106 ISHEEVVNRLLDDFVAACDPVWMQLEADFNPRGNVHTVIRASHGVRQPS 154



 Score = 41.5 bits (96), Expect = 0.034,   Method: Composition-based stats.
 Identities = 19/67 (28%), Positives = 28/67 (41%), Gaps = 3/67 (4%)

Query: 58  TLYELSWLNA-KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLE 116
           TL E + L    G P  A   +        ++E K+ KLY+NS+   R  + +EV   L 
Sbjct: 59  TLPEFTCLCPFSGYPDFATLQLLYQP-GPRVMELKAIKLYVNSYRD-RTISHEEVVNRLL 116

Query: 117 RDLSTCA 123
            D     
Sbjct: 117 DDFVAAC 123


>UniRef50_B0CDX9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=40
           Tax=Cyanobacteria RepID=QUEF_ACAM1
          Length = 144

 Score =  133 bits (335), Expect = 6e-30,   Method: Composition-based stats.
 Identities = 20/101 (19%), Positives = 43/101 (42%), Gaps = 4/101 (3%)

Query: 167 LENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSF 222
           L         +  +  +        C  +  PD+ ++ + Y   Q  ++ + L  Y+ S+
Sbjct: 36  LITFPNPRVGRRYDIHITLPEFTCKCPFSGYPDFATIHLTYVPDQRVVELKALKLYINSY 95

Query: 223 RHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDI 263
           R     HE+ V +I +D++  C P +++V   +  RG +  
Sbjct: 96  RDRYISHEESVNQILDDIVAACDPLEITVKGDFLPRGNVHT 136



 Score = 48.4 bits (114), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 22/128 (17%), Positives = 41/128 (32%), Gaps = 16/128 (12%)

Query: 3   SYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYEL 62
           +  + Q  +    G+            L   P         +      F           
Sbjct: 14  NAQSVQETSESKYGE-----RQIAEGTLITFPNPRVGRRYDIHITLPEFTCK-------- 60

Query: 63  SWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTC 122
                 G P  A  H+        ++E K+ KLY+NS+     ++ + V Q L+  ++ C
Sbjct: 61  --CPFSGYPDFATIHLTYVPD-QRVVELKALKLYINSYRDRYISHEESVNQILDDIVAAC 117

Query: 123 AQGKISVA 130
              +I+V 
Sbjct: 118 DPLEITVK 125


>UniRef50_Q113I7 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2
           Tax=Cyanobacteria RepID=QUEF_TRIEI
          Length = 141

 Score =  132 bits (331), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 20/102 (19%), Positives = 42/102 (41%), Gaps = 4/102 (3%)

Query: 167 LENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSF 222
           L         +  E  +        C  +  PD+ ++ I+Y    R ++ + +  Y+ S+
Sbjct: 31  LITFPNPRIGRRYEINISLPEFTCKCPFSGYPDFATIHIKYIPNERVVELKAIKLYINSY 90

Query: 223 RHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDIN 264
           R     HE+ V +I +D +  C P ++ +   +  RG +   
Sbjct: 91  RERYISHEESVNQILDDFVAACDPLEVKIKGDFLPRGNVHTT 132



 Score = 45.3 bits (106), Expect = 0.002,   Method: Composition-based stats.
 Identities = 21/101 (20%), Positives = 42/101 (41%), Gaps = 15/101 (14%)

Query: 31  QGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSW-LNAKGLPQVAVGHVELDYTSVNLIE 89
              PR   R  + +   +LP          E +      G P  A  H++       ++E
Sbjct: 34  FPNPRIGRRYEINI---SLP----------EFTCKCPFSGYPDFATIHIKYIPN-ERVVE 79

Query: 90  SKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVA 130
            K+ KLY+NS+ +   ++ + V Q L+  ++ C   ++ + 
Sbjct: 80  LKAIKLYINSYRERYISHEESVNQILDDFVAACDPLEVKIK 120


>UniRef50_C1CXM3 Putative GTP cyclohydrolase I n=2 Tax=Deinococcus deserti VCD115
           RepID=C1CXM3_DEIDV
          Length = 155

 Score =  131 bits (330), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 30/152 (19%), Positives = 60/152 (39%), Gaps = 7/152 (4%)

Query: 129 VALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKS 188
           +      +          G  +D  D+ + +        + A    + ++  +++     
Sbjct: 1   MTTTPPCQPGFDRRYDVQG--LDAIDVAVLDTFAYVRQDDPAAYPGEPMDIEIITDEFSP 58

Query: 189 NCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQP 246
            C  +  PD+G L+I+Y+ R   ++ + L  YL S+R    +HE    R+  DL +   P
Sbjct: 59  VCPWSGLPDFGRLEIRYQPREKCVELKSLKYYLTSYRFVGIYHEHATRRLLADLTQLLDP 118

Query: 247 EKLSVYARYTRRGGLDINPWRSNSDFVPSTTR 278
             +++   Y  RGGL+         +V    R
Sbjct: 119 LSMTIRCDYGMRGGLNT---VCTVRYVAPERR 147



 Score = 39.9 bits (92), Expect = 0.087,   Method: Composition-based stats.
 Identities = 18/88 (20%), Positives = 28/88 (31%), Gaps = 12/88 (13%)

Query: 34  PRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSF 93
           P +   +P+ ++     F     W           GLP      +         +E KS 
Sbjct: 39  PAAYPGEPMDIEIITDEFSPVCPW----------SGLPDFGRLEIRYQP-REKCVELKSL 87

Query: 94  KLYLNSFNQTRFNNWDEVRQTLERDLST 121
           K YL S+      +    R  L  DL+ 
Sbjct: 88  KYYLTSYRFVGIYHEHATR-RLLADLTQ 114


>UniRef50_B4U9Q5 7-cyano-7-deazaguanine reductase n=5 Tax=Bacteria
           RepID=B4U9Q5_HYDS0
          Length = 128

 Score =  130 bits (328), Expect = 4e-29,   Method: Composition-based stats.
 Identities = 28/126 (22%), Positives = 47/126 (37%), Gaps = 5/126 (3%)

Query: 153 QDITIDNYEFTTDYLENATCGEK--VVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR-- 208
           Q+      E     LE      K       +        C  +  PD+ +++I+Y     
Sbjct: 3   QEKKYGEIEIEKAALEPWENPAKENDYIIEMSFPEFSCLCPRSGYPDYATIKIRYIPNEY 62

Query: 209 QIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINP-WR 267
            ++ + L  +L SFR+    HE     I+N L    +P+ L V   +  RG L      R
Sbjct: 63  IVELKSLKLWLNSFRNQYISHEAATNTIYNKLFELLKPKFLEVIGDFHPRGNLHTVVRVR 122

Query: 268 SNSDFV 273
           S+  + 
Sbjct: 123 SDKKYD 128



 Score = 47.6 bits (112), Expect = 4e-04,   Method: Composition-based stats.
 Identities = 22/88 (25%), Positives = 33/88 (37%), Gaps = 12/88 (13%)

Query: 61  ELSWLNAK-GLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDL 119
           E S L  + G P  A   +        ++E KS KL+LNSF   ++ + +    T+   L
Sbjct: 37  EFSCLCPRSGYPDYATIKIRYIPN-EYIVELKSLKLWLNSFRN-QYISHEAATNTIYNKL 94

Query: 120 STCAQGKISVALYRLDELEGQPIGHFNG 147
                      L +   LE     H  G
Sbjct: 95  ---------FELLKPKFLEVIGDFHPRG 113


>UniRef50_B0KAC5 NADPH-dependent 7-cyano-7-deazaguanine reductase n=11
           Tax=Clostridia RepID=QUEF_THEP3
          Length = 133

 Score =  129 bits (325), Expect = 8e-29,   Method: Composition-based stats.
 Identities = 29/116 (25%), Positives = 50/116 (43%), Gaps = 12/116 (10%)

Query: 150 IDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ 209
           ID + +    YE+           EK      +++   S C  T  PD   L I+Y   +
Sbjct: 18  IDKEVLESIEYEY----------PEKNTIVEYITNEFSSVCPWTGLPDNAKLTIRYIPSK 67

Query: 210 --IDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDI 263
             ++ + L  YL S+R+     E  + RI +DL+   QP+ + +   +  RGG+  
Sbjct: 68  KLVELKSLKYYLTSYRNVGILQEHAINRILDDLVELLQPKFMEIIGEFQERGGIAT 123



 Score = 43.4 bits (101), Expect = 0.008,   Method: Composition-based stats.
 Identities = 21/84 (25%), Positives = 28/84 (33%), Gaps = 3/84 (3%)

Query: 61  ELSWLNA-KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDL 119
           E S +    GLP  A   +     S  L+E KS K YL S+          +   +  DL
Sbjct: 43  EFSSVCPWTGLPDNAKLTIRYIP-SKKLVELKSLKYYLTSYRNVGILQEHAI-NRILDDL 100

Query: 120 STCAQGKISVALYRLDELEGQPIG 143
               Q K    +    E  G    
Sbjct: 101 VELLQPKFMEIIGEFQERGGIATR 124


>UniRef50_B7JWF0 7-cyano-7-deazaguanine reductase n=8 Tax=Cyanobacteria
           RepID=B7JWF0_CYAP8
          Length = 142

 Score =  128 bits (323), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 17/101 (16%), Positives = 41/101 (40%), Gaps = 4/101 (3%)

Query: 167 LENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSF 222
           L         +  +  +        C  +  PD+ +L + Y   +  ++ + L  Y+  +
Sbjct: 31  LITFPNPRIGRRYDINITLPEFTCKCPFSGYPDFATLYLTYIPDEKVVELKALKLYINRY 90

Query: 223 RHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDI 263
           R     HE+ + +I +D +  C P ++++   +  RG +  
Sbjct: 91  RDRYISHEESINQILDDFVAACDPLEVTLKGDFNPRGNVHT 131



 Score = 41.9 bits (97), Expect = 0.024,   Method: Composition-based stats.
 Identities = 18/101 (17%), Positives = 39/101 (38%), Gaps = 15/101 (14%)

Query: 31  QGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSW-LNAKGLPQVAVGHVELDYTSVNLIE 89
              PR   R  + +    LP          E +      G P  A  ++        ++E
Sbjct: 34  FPNPRIGRRYDINIT---LP----------EFTCKCPFSGYPDFATLYLTYIPD-EKVVE 79

Query: 90  SKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVA 130
            K+ KLY+N +     ++ + + Q L+  ++ C   ++++ 
Sbjct: 80  LKALKLYINRYRDRYISHEESINQILDDFVAACDPLEVTLK 120


>UniRef50_Q5HS73 NADPH-dependent 7-cyano-7-deazaguanine reductase n=20 Tax=Bacteria
           RepID=QUEF_CAMJR
          Length = 127

 Score =  128 bits (322), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 22/117 (18%), Positives = 47/117 (40%), Gaps = 4/117 (3%)

Query: 161 EFTTDYLENATCGEK-VVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLR 217
           EF  + +E      K      +        C  +  PD+ ++ ++Y   +  ++ + +  
Sbjct: 10  EFDVENMEIWPNDAKNDYIIKITLPEFMCCCPRSGYPDFATIYLEYMPNKFVVELKAIKL 69

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDI-NPWRSNSDFV 273
           Y+ +F + N  HE  +  I+N L    +P+ + V   +  RG +      RS+    
Sbjct: 70  YINTFMYRNVSHEASINEIYNTLKDKLKPKWIKVVGDFNPRGNVHTVIECRSDMVVP 126


>UniRef50_A5IIZ4 NADPH-dependent 7-cyano-7-deazaguanine reductase n=7
           Tax=Thermotogaceae RepID=QUEF_THEP1
          Length = 137

 Score =  125 bits (315), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 27/104 (25%), Positives = 47/104 (45%), Gaps = 3/104 (2%)

Query: 164 TDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR---QIDREKLLRYLV 220
           TD+LE      K     + +    + C  +  PD G + I+Y       ++ + L  Y V
Sbjct: 19  TDFLEAIDFDGKDEYIKIETDEFSAVCPFSGLPDIGRVIIEYYPDGGKIVELKSLKYYFV 78

Query: 221 SFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDIN 264
           SFR+   + E+  +RI+ DL    + +++ V   Y  RGG+   
Sbjct: 79  SFRNVGIYQEEATKRIYEDLKNLLKTDRIRVTVIYNIRGGIKTT 122



 Score = 45.3 bits (106), Expect = 0.002,   Method: Composition-based stats.
 Identities = 18/84 (21%), Positives = 30/84 (35%), Gaps = 5/84 (5%)

Query: 47  DNLPFHGTDIW---TLYELSWLNA-KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQ 102
           + + F G D +      E S +    GLP +    +E       ++E KS K Y  SF  
Sbjct: 23  EAIDFDGKDEYIKIETDEFSAVCPFSGLPDIGRVIIEYYPDGGKIVELKSLKYYFVSFRN 82

Query: 103 TRFNNWDEVRQTLERDLSTCAQGK 126
                 +  +  +  DL    +  
Sbjct: 83  VGIYQEEATK-RIYEDLKNLLKTD 105


>UniRef50_A8W229 ATP-dependent metalloprotease FtsH n=1 Tax=Bacillus
           selenitireducens MLS10 RepID=A8W229_9BACI
          Length = 135

 Score =  125 bits (315), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 27/109 (24%), Positives = 49/109 (44%), Gaps = 3/109 (2%)

Query: 159 NYEFTTDYLENATCGEKVVEET-LVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKL 215
           + E   + L +       V      +    + C  T QPD+G ++I+Y  R   I+ + L
Sbjct: 18  SVEEGRNVLRDEAFPAPDVSVVRFKALEFTAVCPKTGQPDFGQVEIEYVPRNKCIESKSL 77

Query: 216 LRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDIN 264
             YL S+R    + E    +I +D++   +P ++ V    T RGG+ + 
Sbjct: 78  KFYLWSYRDEGAYCESLAAQIADDVMAAIEPARVKVMVHQTPRGGIQLE 126



 Score = 50.7 bits (120), Expect = 5e-05,   Method: Composition-based stats.
 Identities = 22/106 (20%), Positives = 38/106 (35%), Gaps = 6/106 (5%)

Query: 32  GVPR----SLNRDPLGLKADNLPFHGTDIWTLYELSWLNAK-GLPQVAVGHVELDYTSVN 86
            +PR       R+ L  +A   P      +   E + +  K G P      +E    +  
Sbjct: 12  PMPRPASVEEGRNVLRDEAFPAPDVSVVRFKALEFTAVCPKTGQPDFGQVEIEYVPRN-K 70

Query: 87  LIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALY 132
            IESKS K YL S+            Q  +  ++     ++ V ++
Sbjct: 71  CIESKSLKFYLWSYRDEGAYCESLAAQIADDVMAAIEPARVKVMVH 116


>UniRef50_B5JRC9 7-cyano-7-deazaguanine reductase n=1 Tax=Verrucomicrobiae bacterium
           DG1235 RepID=B5JRC9_9BACT
          Length = 126

 Score =  125 bits (315), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 30/104 (28%), Positives = 49/104 (47%), Gaps = 2/104 (1%)

Query: 163 TTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLV 220
             D L+     E V   T+ S  L S+C IT QPD+ ++ I+Y  +   I+ + L  +L 
Sbjct: 13  PIDELDTFEAPEGVTTVTMTSDELTSSCPITGQPDFYNVSIEYAPKELCIESKSLKLFLW 72

Query: 221 SFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDIN 264
            FR    F E+    I + +++   P +  V      RGG++I 
Sbjct: 73  GFRDKAMFAEKIAAVICDRVVQDISPRRCRVMTFQKARGGIEIE 116


>UniRef50_B5IBP5 7-cyano-7-deazaguanine reductase n=2 Tax=Aciduliprofundum boonei
           T469 RepID=B5IBP5_9EURY
          Length = 135

 Score =  120 bits (302), Expect = 4e-26,   Method: Composition-based stats.
 Identities = 23/99 (23%), Positives = 40/99 (40%), Gaps = 2/99 (2%)

Query: 171 TCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEF 228
              E       +   L + C  T  PD+  L+I Y   +   + + L  YL+++R+   +
Sbjct: 12  EYPETKEVVEYIYPELTAVCPQTGLPDYYILRILYEPDKKLPELKSLKMYLIAYRNFGIW 71

Query: 229 HEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWR 267
           HE    +I +D     +P  + V      RGG+     R
Sbjct: 72  HEHLANKILDDFKSAVEPRWVYVELYVNNRGGIYTTVRR 110


>UniRef50_D0MDN3 7-cyano-7-deazaguanine reductase n=1 Tax=Rhodothermus marinus DSM
           4252 RepID=D0MDN3_RHOM4
          Length = 168

 Score =  105 bits (261), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 25/83 (30%), Positives = 39/83 (46%), Gaps = 3/83 (3%)

Query: 185 LLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEFHEQCVERIFNDLLR 242
              + C  +  PD+G L+I+Y      ++ + L  Y+VS+R+     E     I+ DL+R
Sbjct: 76  EFSAVCPFSGLPDYGVLRIEYVPGSWILELKSLKYYIVSWRNIGAAQEDLTAIIYQDLMR 135

Query: 243 FC-QPEKLSVYARYTRRGGLDIN 264
               PE L V   Y  RGG+   
Sbjct: 136 HLEDPEYLRVITVYNVRGGIRTT 158


>UniRef50_Q9YBX9 Putative GTP cyclohydrolase I n=1 Tax=Aeropyrum pernix
           RepID=Q9YBX9_AERPE
          Length = 101

 Score = 76.5 bits (187), Expect = 9e-13,   Method: Composition-based stats.
 Identities = 19/67 (28%), Positives = 28/67 (41%), Gaps = 2/67 (2%)

Query: 188 SNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQ 245
           + C  T  PD   ++I+Y  R   ++   L  +L SFR      EQ    I   L    +
Sbjct: 8   AVCPFTGAPDSYDVEIEYVSRDACLEALSLASWLESFRGVKISQEQLAHEIALTLKELLK 67

Query: 246 PEKLSVY 252
           PE + V 
Sbjct: 68  PEYVCVK 74


>UniRef50_A2BLN0 Predicted GTP cyclohydrolase I n=1 Tax=Hyperthermus butylicus DSM
           5456 RepID=A2BLN0_HYPBU
          Length = 119

 Score = 73.5 bits (179), Expect = 8e-12,   Method: Composition-based stats.
 Identities = 17/93 (18%), Positives = 35/93 (37%), Gaps = 7/93 (7%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG-------RQIDREKLLRYLVS 221
               GE  VE+ +++  +++ C +T   D   + ++Y+        R I+      YL S
Sbjct: 7   RVVEGEACVEKVVLTGSVEAVCPVTGMVDLYRVIVEYKPSSAGRVCRYIEALSFHFYLQS 66

Query: 222 FRHHNEFHEQCVERIFNDLLRFCQPEKLSVYAR 254
           ++      E+    I  D        ++ V   
Sbjct: 67  YKGRKILQEELTATIVRDFCEALGGGEVKVVTE 99


>UniRef50_B1YDZ8 GTP cyclohydrolase I n=5 Tax=Thermoproteaceae RepID=B1YDZ8_THENV
          Length = 114

 Score = 51.9 bits (123), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 16/91 (17%), Positives = 34/91 (37%), Gaps = 7/91 (7%)

Query: 188 SNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQ 245
           + C I+   D   + ++Y  R   +  E+  R + S+R     HE+    +   +     
Sbjct: 24  AVCPISKVVDSFEVTVEYMPRGGALAIEEFKRMVDSYRGREILHEELAVDLMEKIKAAVN 83

Query: 246 PEKLSV--YARYTRRGGLDINPWRSNSDFVP 274
           P  + V   + Y    G+++     +    P
Sbjct: 84  PPYVKVVLKSVYI---GVEVEVVAESGGVPP 111


>UniRef50_B1SCE4 Putative uncharacterized protein n=1 Tax=Streptococcus infantarius
           subsp. infantarius ATCC BAA-102 RepID=B1SCE4_9STRE
          Length = 58

 Score = 44.6 bits (104), Expect = 0.004,   Method: Composition-based stats.
 Identities = 11/27 (40%), Positives = 18/27 (66%)

Query: 240 LLRFCQPEKLSVYARYTRRGGLDINPW 266
           ++   QP  L V+ ++T RGGL I+P+
Sbjct: 1   MIDLLQPRYLEVWGKFTPRGGLSIDPY 27


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q0T1R0 NADPH-dependent 7-cyano-7-deazaguanine reductase...   397   e-109
UniRef50_Q0HGT5 NADPH-dependent 7-cyano-7-deazaguanine reductase...   364   2e-99
UniRef50_Q7WH69 NADPH-dependent 7-cyano-7-deazaguanine reductase...   358   1e-97
UniRef50_Q1K442 GTP cyclohydrolase I n=2 Tax=Proteobacteria RepI...   353   5e-96
UniRef50_A4T050 GTP cyclohydrolase I n=2 Tax=Proteobacteria RepI...   350   4e-95
UniRef50_A4VK37 GTP cyclohydrolase I, putative n=2 Tax=Gammaprot...   350   5e-95
UniRef50_Q0VR70 NADPH-dependent 7-cyano-7-deazaguanine reductase...   344   2e-93
UniRef50_Q5P6G9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   343   3e-93
UniRef50_Q1LSV9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   336   5e-91
UniRef50_Q6ARX8 NADPH-dependent 7-cyano-7-deazaguanine reductase...   335   9e-91
UniRef50_Q21VW6 NADPH-dependent 7-cyano-7-deazaguanine reductase...   333   3e-90
UniRef50_Q5X7D5 NADPH-dependent 7-cyano-7-deazaguanine reductase...   330   3e-89
UniRef50_Q6FA61 NADPH-dependent 7-cyano-7-deazaguanine reductase...   329   6e-89
UniRef50_A8F0H9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   323   6e-87
UniRef50_B8KG68 NADPH-dependent 7-cyano-7-deazaguanine reductase...   322   7e-87
UniRef50_C8PYF2 Queuine synthase n=3 Tax=Moraxellaceae RepID=C8P...   316   5e-85
UniRef50_A4A3I6 GTP cyclohydrolase I n=1 Tax=Congregibacter lito...   313   4e-84
UniRef50_B8KRQ4 NADPH-dependent 7-cyano-7-deazaguanine reductase...   308   2e-82
UniRef50_A0Z1W1 Putative uncharacterized protein n=1 Tax=marine ...   305   1e-81
UniRef50_Q1QDK8 NADPH-dependent 7-cyano-7-deazaguanine reductase...   304   2e-81
UniRef50_P44165 Uncharacterized protein HI1340 n=9 Tax=Gammaprot...   274   3e-72
UniRef50_Q6WI29 GTP cyclohydrolase I family protein n=1 Tax=Vibr...   269   7e-71
UniRef50_B7RUV0 GTP cyclohydrolase I subfamily, putative n=1 Tax...   205   2e-51
UniRef50_B8DRK9 7-cyano-7-deazaguanine reductase n=2 Tax=Desulfo...   168   2e-40
UniRef50_A9VKS1 NADPH-dependent 7-cyano-7-deazaguanine reductase...   166   9e-40
UniRef50_Q2IH01 NADPH-dependent 7-cyano-7-deazaguanine reductase...   165   1e-39
UniRef50_C7JB01 Queuosine biosynthesis protein QueF n=9 Tax=Alph...   162   1e-38
UniRef50_Q3SJI1 NADPH-dependent 7-cyano-7-deazaguanine reductase...   161   3e-38
UniRef50_C4XPJ6 Putative uncharacterized protein n=1 Tax=Desulfo...   160   4e-38
UniRef50_Q0AAV5 NADPH-dependent 7-cyano-7-deazaguanine reductase...   160   6e-38
UniRef50_B3E3W5 7-cyano-7-deazaguanine reductase n=3 Tax=Proteob...   159   8e-38
UniRef50_B8IYG6 NADPH-dependent 7-cyano-7-deazaguanine reductase...   158   1e-37
UniRef50_Q8UD54 NADPH-dependent 7-cyano-7-deazaguanine reductase...   157   3e-37
UniRef50_A1WY83 NADPH-dependent 7-cyano-7-deazaguanine reductase...   157   5e-37
UniRef50_Q8GJN6 NADPH-dependent 7-cyano-7-deazaguanine reductase...   156   8e-37
UniRef50_D2L9R9 7-cyano-7-deazaguanine reductase n=1 Tax=Desulfo...   156   9e-37
UniRef50_C7M0Q2 7-cyano-7-deazaguanine reductase n=1 Tax=Acidimi...   156   1e-36
UniRef50_A6C8E2 Putative uncharacterized protein n=2 Tax=Plancto...   155   1e-36
UniRef50_Q2LTJ0 NADPH-dependent 7-cyano-7-deazaguanine reductase...   154   3e-36
UniRef50_Q9ZJJ9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   153   6e-36
UniRef50_Q6MRJ2 NADPH-dependent 7-cyano-7-deazaguanine reductase...   152   1e-35
UniRef50_D1N404 7-cyano-7-deazaguanine reductase n=3 Tax=Bacteri...   149   1e-34
UniRef50_B2UN89 7-cyano-7-deazaguanine reductase n=2 Tax=Verruco...   148   2e-34
UniRef50_B3QM19 NADPH-dependent 7-cyano-7-deazaguanine reductase...   148   3e-34
UniRef50_B7J648 NADPH-dependent 7-cyano-7-deazaguanine reductase...   146   8e-34
UniRef50_B3EMR0 NADPH-dependent 7-cyano-7-deazaguanine reductase...   145   1e-33
UniRef50_Q8DMA3 NADPH-dependent 7-cyano-7-deazaguanine reductase...   145   2e-33
UniRef50_B8HRW7 7-cyano-7-deazaguanine reductase n=2 Tax=Cyanoba...   145   2e-33
UniRef50_Q04RM8 NADPH-dependent 7-cyano-7-deazaguanine reductase...   145   2e-33
UniRef50_A8ZUH0 GTP cyclohydrolase I n=2 Tax=Desulfobacteraceae ...   142   2e-32
UniRef50_C1CXM3 Putative GTP cyclohydrolase I n=2 Tax=Deinococcu...   141   2e-32
UniRef50_C0GIY6 7-cyano-7-deazaguanine reductase n=1 Tax=Dethiob...   141   3e-32
UniRef50_B5IMF1 7-cyano-7-deazaguanine reductase n=1 Tax=Cyanobi...   141   3e-32
UniRef50_Q113I7 NADPH-dependent 7-cyano-7-deazaguanine reductase...   140   4e-32
UniRef50_Q8DNP8 NADPH-dependent 7-cyano-7-deazaguanine reductase...   140   6e-32
UniRef50_B0CDX9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   140   6e-32
UniRef50_B4U9Q5 7-cyano-7-deazaguanine reductase n=5 Tax=Bacteri...   140   7e-32
UniRef50_Q2J7K4 NADPH-dependent 7-cyano-7-deazaguanine reductase...   138   2e-31
UniRef50_B2KDU6 NADPH-dependent 7-cyano-7-deazaguanine reductase...   137   3e-31
UniRef50_A6Q0W4 NADPH-dependent 7-cyano-7-deazaguanine reductase...   137   4e-31
UniRef50_B7JWF0 7-cyano-7-deazaguanine reductase n=8 Tax=Cyanoba...   135   2e-30
UniRef50_D2REX4 GTP cyclohydrolase I n=1 Tax=Archaeoglobus profu...   134   3e-30
UniRef50_Q5HS73 NADPH-dependent 7-cyano-7-deazaguanine reductase...   132   1e-29
UniRef50_B0KAC5 NADPH-dependent 7-cyano-7-deazaguanine reductase...   131   3e-29
UniRef50_A5IIZ4 NADPH-dependent 7-cyano-7-deazaguanine reductase...   127   4e-28
UniRef50_B5JRC9 7-cyano-7-deazaguanine reductase n=1 Tax=Verruco...   127   6e-28
UniRef50_A8W229 ATP-dependent metalloprotease FtsH n=1 Tax=Bacil...   126   1e-27
UniRef50_B5IBP5 7-cyano-7-deazaguanine reductase n=2 Tax=Aciduli...   120   5e-26
UniRef50_D0MDN3 7-cyano-7-deazaguanine reductase n=1 Tax=Rhodoth...   105   2e-21
UniRef50_A2BLN0 Predicted GTP cyclohydrolase I n=1 Tax=Hyperther...    80   9e-14
UniRef50_Q9YBX9 Putative GTP cyclohydrolase I n=1 Tax=Aeropyrum ...    78   3e-13
UniRef50_B1YDZ8 GTP cyclohydrolase I n=5 Tax=Thermoproteaceae Re...    75   4e-12

Sequences not found previously or not previously below threshold:

UniRef50_B1SCE4 Putative uncharacterized protein n=1 Tax=Strepto...    43   0.011


CONVERGED!
>UniRef50_Q0T1R0 NADPH-dependent 7-cyano-7-deazaguanine reductase n=139
           Tax=Gammaproteobacteria RepID=QUEF_SHIF8
          Length = 282

 Score =  397 bits (1021), Expect = e-109,   Method: Composition-based stats.
 Identities = 280/282 (99%), Positives = 281/282 (99%)

Query: 1   MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLY 60
           MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLY
Sbjct: 1   MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLY 60

Query: 61  ELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLS 120
           ELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLS
Sbjct: 61  ELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLS 120

Query: 121 TCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEET 180
           TCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENAT GEKVVEET
Sbjct: 121 TCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATSGEKVVEET 180

Query: 181 LVSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDL 240
           LVSHLLKSNCLITHQPDWGS+QIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDL
Sbjct: 181 LVSHLLKSNCLITHQPDWGSIQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDL 240

Query: 241 LRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           LRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ
Sbjct: 241 LRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282


>UniRef50_Q0HGT5 NADPH-dependent 7-cyano-7-deazaguanine reductase n=142
           Tax=Proteobacteria RepID=QUEF_SHESM
          Length = 286

 Score =  364 bits (934), Expect = 2e-99,   Method: Composition-based stats.
 Identities = 177/279 (63%), Positives = 219/279 (78%)

Query: 4   YANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELS 63
           Y++ + LAGLTLGK+TDY+  YDASLLQGVPRSLNR+ + L A++LPFHG DIWT YELS
Sbjct: 8   YSDAKELAGLTLGKATDYQAEYDASLLQGVPRSLNRNAINLTAESLPFHGADIWTAYELS 67

Query: 64  WLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCA 123
           WLNAKG P VA+  ++L + S NLIESKSFKLYLNSFNQT+F+N D V++TL +DLS CA
Sbjct: 68  WLNAKGKPMVAIADIQLSHESQNLIESKSFKLYLNSFNQTKFDNIDAVQKTLVQDLSECA 127

Query: 124 QGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVS 183
           QG+++V +        Q +    GTCIDD DI + +Y+F  DYLEN+T  +++V ETL S
Sbjct: 128 QGQVTVKIIEPKSFGIQRVVELPGTCIDDLDIEVSDYDFNPDYLENSTDDKQIVAETLNS 187

Query: 184 HLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRF 243
           +LLKSNCLIT QPDWGS+ I+Y+G +IDREKLLRYL+SFR HNEFHEQCVERIF DL  +
Sbjct: 188 NLLKSNCLITSQPDWGSVMIRYQGPKIDREKLLRYLISFRQHNEFHEQCVERIFVDLKHY 247

Query: 244 CQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           C   KL+VYARYTRRGGLDINP+RS+ +    + RL RQ
Sbjct: 248 CHCTKLTVYARYTRRGGLDINPYRSDFEHPGESHRLARQ 286


>UniRef50_Q7WH69 NADPH-dependent 7-cyano-7-deazaguanine reductase n=5
           Tax=Proteobacteria RepID=QUEF_BORBR
          Length = 273

 Score =  358 bits (919), Expect = 1e-97,   Method: Composition-based stats.
 Identities = 142/276 (51%), Positives = 173/276 (62%), Gaps = 4/276 (1%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNA 67
            +L+   LG+   Y   YD  LL  +PR+ NR  L L    LPF G D+W  YELSWL+A
Sbjct: 1   MSLSNAPLGQHVAYPSQYDPGLLFPIPRATNRASLQL-GATLPFTGVDLWNAYELSWLDA 59

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKI 127
           +G P+VA+        S N++ESKSFKLYLNSFNQTR  N   +R  LERDL+  A   +
Sbjct: 60  RGKPRVAMATFSFPADSPNIVESKSFKLYLNSFNQTRLPNAQALRDRLERDLAAAAGAPV 119

Query: 128 SVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLK 187
            +            +   +G  ID  DI ID YE     L+ A   E  VEETL + LLK
Sbjct: 120 GLEFISPQRFGELNMAELDGIYIDKLDIEIDTYEPAPQLLQCAPGDE--VEETLATRLLK 177

Query: 188 SNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           SNC +T QPDW SLQ++YRGR IDR  LL+Y+VSFR H EFHE CVERIF D++R CQP 
Sbjct: 178 SNCPVTGQPDWASLQVRYRGRPIDRAALLKYVVSFRQHAEFHEHCVERIFGDIMRACQPR 237

Query: 248 KLSVYARYTRRGGLDINPWRSNSDF-VPSTTRLVRQ 282
           +L+VYARYTRRGGLDINPWRSN +   P+  R  RQ
Sbjct: 238 QLTVYARYTRRGGLDINPWRSNFESAPPADVRTARQ 273


>UniRef50_Q1K442 GTP cyclohydrolase I n=2 Tax=Proteobacteria RepID=Q1K442_DESAC
          Length = 275

 Score =  353 bits (905), Expect = 5e-96,   Method: Composition-based stats.
 Identities = 148/275 (53%), Positives = 181/275 (65%), Gaps = 1/275 (0%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNA 67
             L  + LGK+T+Y   YDA LL  VPR L RD LG+  + LPF+G D+W  YELSWLN 
Sbjct: 2   SDLTEIPLGKTTEYPSQYDAGLLYPVPRHLKRDELGIS-EPLPFYGEDVWNSYELSWLNR 60

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKI 127
           KG P VA+        S NL+ESKSFKLYLNS NQTRF++   V   L+RDLS  +   +
Sbjct: 61  KGKPVVALAVFRFSCQSPNLVESKSFKLYLNSLNQTRFDDQQAVIDCLQRDLSQASGSSV 120

Query: 128 SVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLK 187
           +V L  LD+     +    G C+D  D+ +++Y+   D L +A      VEETL SHLLK
Sbjct: 121 TVELSSLDDQSLWQVQTLPGECLDSVDLDVEHYQLNADLLRDAADSADPVEETLYSHLLK 180

Query: 188 SNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           SNCLIT QPDW S+ I YRG +++R  LL YL+SFR HNEFHEQCVERIF DL+R+C P+
Sbjct: 181 SNCLITSQPDWASVWISYRGGRLERRALLAYLISFRQHNEFHEQCVERIFADLMRYCHPQ 240

Query: 248 KLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
            L+VYARYTRRGGLDINPWRS         RL RQ
Sbjct: 241 SLTVYARYTRRGGLDINPWRSTEPGTAPQWRLSRQ 275


>UniRef50_A4T050 GTP cyclohydrolase I n=2 Tax=Proteobacteria RepID=A4T050_POLSQ
          Length = 275

 Score =  350 bits (898), Expect = 4e-95,   Method: Composition-based stats.
 Identities = 138/275 (50%), Positives = 176/275 (64%), Gaps = 2/275 (0%)

Query: 10  LAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGL-KADNLPFHGTDIWTLYELSWLNAK 68
           +A L LG+ST Y D YD SLL  +PR+ NR  LGL +   LPF G DIW  +ELSWLN K
Sbjct: 1   MATLPLGQSTQYPDQYDPSLLFPIPRTENRAKLGLKEGQALPFVGIDIWNAFELSWLNQK 60

Query: 69  GLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKIS 128
           G PQ+A+   ++   S N+IESKSFKLYLNS N  RF +  +V+  L  DLS  A  K++
Sbjct: 61  GKPQIALAEFQIPADSPNMIESKSFKLYLNSLNSARFEDEGQVKDRLITDLSAVAGSKVA 120

Query: 129 VALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKS 188
             ++  + +  + +   +G  +D  DI ID +      L         +E+ LVSHLLKS
Sbjct: 121 TRIHSTEAVSKKGMQEMSGILMDRLDIEIDPHLPADPSLLGVNESFGPIEQCLVSHLLKS 180

Query: 189 NCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEK 248
           NC +T QPDW S+QI+Y+GR I  E LLRYL+ FR   EFHE CVE IF D+ R C+PEK
Sbjct: 181 NCPVTGQPDWASVQIRYQGRPILEEGLLRYLIGFRQLGEFHEHCVETIFTDIKRQCKPEK 240

Query: 249 LSVYARYTRRGGLDINPWRSNSDFV-PSTTRLVRQ 282
           LSVYARYTRRGGLDINP+R++ +   P  TR  RQ
Sbjct: 241 LSVYARYTRRGGLDINPFRTDHNSPWPENTRHARQ 275


>UniRef50_A4VK37 GTP cyclohydrolase I, putative n=2 Tax=Gammaproteobacteria
           RepID=A4VK37_PSEU5
          Length = 298

 Score =  350 bits (897), Expect = 5e-95,   Method: Composition-based stats.
 Identities = 141/277 (50%), Positives = 176/277 (63%), Gaps = 2/277 (0%)

Query: 6   NHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWL 65
            H A     LGKS+DY  TY   LL  +PR+     LGL A+ LP+ G D+W  YELSWL
Sbjct: 24  QHPAEH-SPLGKSSDYVATYSPGLLFPIPRAPKWVELGLTAETLPYQGVDLWNCYELSWL 82

Query: 66  NAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQG 125
              G P VA+G  E+   S ++IESKSFKLYLNS NQ+ F + + + + +  DLS  A  
Sbjct: 83  LPSGKPVVAIGEFEIPADSPSIIESKSFKLYLNSLNQSVFESREALAEVMSSDLSAAAGK 142

Query: 126 KISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHL 185
            + V L  LDE+  + +    G C+DD D+TI++Y+     L        +VEE+L SHL
Sbjct: 143 PVKVRLRTLDEVAAEGVATLPGRCVDDLDVTIEHYDHPQPGLLACDA-GHMVEESLHSHL 201

Query: 186 LKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQ 245
           LKSNC +T QPDWGS+ ++YRG  +  E LL YLVSFR H +FHEQCVERIF DL R  Q
Sbjct: 202 LKSNCPVTGQPDWGSVVVEYRGAALQAESLLAYLVSFRQHADFHEQCVERIFLDLQRLLQ 261

Query: 246 PEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           PEKL+VYARY RRGGLDINP+RS    V    RLVRQ
Sbjct: 262 PEKLTVYARYVRRGGLDINPYRSTGAMVVDNRRLVRQ 298


>UniRef50_Q0VR70 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2
           Tax=Alcanivorax RepID=QUEF_ALCBS
          Length = 274

 Score =  344 bits (882), Expect = 2e-93,   Method: Composition-based stats.
 Identities = 128/273 (46%), Positives = 174/273 (63%), Gaps = 2/273 (0%)

Query: 10  LAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKG 69
           L    LG+S++Y D Y  SLL  VPR   R+ L L++  LPFHG+DIW  YELSWLN KG
Sbjct: 4   LKETPLGRSSEYVDQYMPSLLCPVPRWDAREGLELESATLPFHGSDIWNAYELSWLNEKG 63

Query: 70  LPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISV 129
            P VA+  + +  T+ N++ESKS KLYLNSF  TRF + D VR  +E+D++  A G I V
Sbjct: 64  KPIVAMCELRVPCTTPNIVESKSLKLYLNSFANTRFQSRDAVRAAIEKDVAQTAGGNIEV 123

Query: 130 ALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSN 189
            L+ L E  G P+    G C+D+ D+  ++YE+  D L      E+     L SHLL+S+
Sbjct: 124 LLFSLQESAGFPVWEDRGDCVDNIDLNFEHYEYRPDLLLCDQGPEQ--TGQLYSHLLRSH 181

Query: 190 CLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKL 249
           C +T QPDW ++ ++Y GR I     LRY+VS R+H  FHEQ +E++F DL+  C P  L
Sbjct: 182 CPVTDQPDWATVVVRYTGRAISPASFLRYVVSLRNHQGFHEQIIEQMFVDLMTQCSPRHL 241

Query: 250 SVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           +VY R+TRRGG+DINP+RSNS+      R +RQ
Sbjct: 242 TVYGRFTRRGGIDINPFRSNSEQPLPNRRTIRQ 274


>UniRef50_Q5P6G9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=1
           Tax=Aromatoleum aromaticum EbN1 RepID=QUEF_AZOSE
          Length = 283

 Score =  343 bits (881), Expect = 3e-93,   Method: Composition-based stats.
 Identities = 147/282 (52%), Positives = 180/282 (63%), Gaps = 3/282 (1%)

Query: 2   SSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYE 61
           S   +H A A   LG+S  YRD+Y   LL  + R + RD LGL  D LPF G D+W  YE
Sbjct: 4   SDTHDHGAEA-SPLGQSVVYRDSYAPELLFPIARQIKRDELGLAPDTLPFVGEDLWNAYE 62

Query: 62  LSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLST 121
           LSWLN++G P  A+G   +  TS  LIESKS KLYLNSFNQ RF +   V  TL RDLST
Sbjct: 63  LSWLNSRGKPVAAIGTFRVPVTSPRLIESKSLKLYLNSFNQHRFVDPTLVHDTLTRDLST 122

Query: 122 CAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETL 181
            A   ++V++  L     +  G+ +G  +D+ DI ID Y     +L++       V ETL
Sbjct: 123 AAGAPVAVSIEVLSRRPTRVFGYPHGVLLDEIDIEIDTYRTDPAFLQS-DFNADEVSETL 181

Query: 182 VSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLL 241
            SHLLKSNCL+T QPDWG++ ++Y G  IDR  LLRY+VSFR HNEFHEQCVERIF D+L
Sbjct: 182 YSHLLKSNCLVTGQPDWGTIVLRYIGPPIDRAGLLRYIVSFRSHNEFHEQCVERIFCDVL 241

Query: 242 RFCQPEKLSVYARYTRRGGLDINPWRSNSDF-VPSTTRLVRQ 282
           R C P  L+V+ARYTRRGGLDINP+RS   F        VRQ
Sbjct: 242 RRCAPRHLAVWARYTRRGGLDINPFRSTGHFTQFDNIAEVRQ 283


>UniRef50_Q1LSV9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2
           Tax=Gammaproteobacteria RepID=QUEF_BAUCH
          Length = 283

 Score =  336 bits (862), Expect = 5e-91,   Method: Composition-based stats.
 Identities = 152/281 (54%), Positives = 194/281 (69%), Gaps = 4/281 (1%)

Query: 5   ANHQALAGLTLGK-STDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELS 63
             +Q L    L K    YR  Y+  LLQ +PR+++R+ LG+ + +LPF G D WTLYELS
Sbjct: 4   QQYQLLQKFKLDKSKISYRTHYNPMLLQPIPRTIHRELLGISSISLPFQGADFWTLYELS 63

Query: 64  WLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCA 123
           WLN  GLPQVA+G + +D TS NLIES+S KLYLNS NQT F++  E+R TL  D++ C 
Sbjct: 64  WLNKYGLPQVAIGEMIIDATSDNLIESQSLKLYLNSINQTCFSSEQELRNTLITDITKCI 123

Query: 124 QGKISVALYRLDELEGQPIGHFNGTCIDDQDITI--DNYEFTTDYLENATCGEKVVEETL 181
             ++ + ++ L +    PI  F G CID+Q I I  DNY F ++ L N+   EK V+ETL
Sbjct: 124 NSQVKITIHSLSQWMTVPILEFTGECIDNQSIQIDNDNYIFNSNLLVNSVEREK-VKETL 182

Query: 182 VSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLL 241
           VSHLLKSNC IT+QPDWGS+QI Y G +I+RE LLRYL+SFR +  FHEQCVE+I+ D++
Sbjct: 183 VSHLLKSNCPITNQPDWGSVQISYYGMRINREALLRYLISFRKYKIFHEQCVEQIYCDIM 242

Query: 242 RFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           +FC P  LSVY RY RRGGLDINPWRSN  + P    L RQ
Sbjct: 243 QFCLPNTLSVYVRYNRRGGLDINPWRSNISYSPVNRPLARQ 283


>UniRef50_Q6ARX8 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2
           Tax=Proteobacteria RepID=QUEF_DESPS
          Length = 276

 Score =  335 bits (860), Expect = 9e-91,   Method: Composition-based stats.
 Identities = 133/274 (48%), Positives = 172/274 (62%), Gaps = 6/274 (2%)

Query: 11  AGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGL 70
           AG+ LGK   + +TYD S L  V R   R  LGL AD+LPF G DIW  YELSWL++KG 
Sbjct: 7   AGIPLGKQVGHSETYDPSHLFPVARREARKSLGL-ADDLPFSGPDIWNAYELSWLDSKGK 65

Query: 71  PQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVA 130
           P VA+G +    TS N+IESKS KLYLNSFN TRF +   V++ +  DLS  A  ++ V 
Sbjct: 66  PCVALGEITFPCTSENIIESKSLKLYLNSFNLTRFTSTARVKEIIREDLSRVAGAEVEVK 125

Query: 131 LYRLDELEGQPIGHFNGTCIDDQDIT--IDNYEFTTDYLENATCGEKVVEETLVSHLLKS 188
           +   +E     I    G+CIDD ++   I+ Y  T +YL          EE L ++LL++
Sbjct: 126 ILTPEEFTEVTISAPEGSCIDDLELEEEINAYRPTANYLSTGPEE---TEEELYTNLLRT 182

Query: 189 NCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEK 248
           NC +T QPDW ++ I YRG+ ID+  LLRY++SFR H  FHE CVERIF D+L  C P +
Sbjct: 183 NCPVTGQPDWATVIINYRGKAIDQRGLLRYIISFRQHEGFHENCVERIFMDILNRCAPAR 242

Query: 249 LSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           L+VYAR+TRRGGLDINP+R+         RL RQ
Sbjct: 243 LTVYARFTRRGGLDINPYRTTHAEHFVNLRLARQ 276


>UniRef50_Q21VW6 NADPH-dependent 7-cyano-7-deazaguanine reductase n=143
           Tax=Proteobacteria RepID=QUEF_RHOFD
          Length = 289

 Score =  333 bits (855), Expect = 3e-90,   Method: Composition-based stats.
 Identities = 140/287 (48%), Positives = 175/287 (60%), Gaps = 17/287 (5%)

Query: 11  AGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGL 70
               LG++T Y D YDASLL  + R+  R  +G+    LPF G D+WT +ELSWLN +G 
Sbjct: 5   QNSPLGQATAYLDQYDASLLFPIARATKRAEIGVTG-ALPFLGADMWTAFELSWLNLRGK 63

Query: 71  PQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLS---------- 120
           PQVA+    +   S N+IESKSFKLYLNSFN TRF + D V+  L  DLS          
Sbjct: 64  PQVALARFTVPCESPNIIESKSFKLYLNSFNNTRFADVDAVKARLRADLSEAVWRDAGKN 123

Query: 121 ----TCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKV 176
                 A   I V L   +  + +PI   +G  +D  D+   +Y    D L      E  
Sbjct: 124 VSPDAAAPPSIGVTLLLPELFDREPIYELDGLSLDRLDVECTHYTPAPDLLRVVP-DEAP 182

Query: 177 VEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERI 236
           V E LVS+LLKSNC +T QPDW S+QI Y G  ID+E LL+YLVSFR+HNEFHEQCVERI
Sbjct: 183 VSEVLVSNLLKSNCPVTGQPDWASVQISYSGAPIDQEGLLQYLVSFRNHNEFHEQCVERI 242

Query: 237 FNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDF-VPSTTRLVRQ 282
           F DL   C+P +L+VYARYTRRGGLDINP+R++    +P+  R  RQ
Sbjct: 243 FMDLWTRCKPVRLAVYARYTRRGGLDINPFRTSYAQALPANVRNARQ 289


>UniRef50_Q5X7D5 NADPH-dependent 7-cyano-7-deazaguanine reductase n=43 Tax=Bacteria
           RepID=QUEF_LEGPA
          Length = 285

 Score =  330 bits (846), Expect = 3e-89,   Method: Composition-based stats.
 Identities = 134/274 (48%), Positives = 179/274 (65%), Gaps = 6/274 (2%)

Query: 12  GLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLP 71
              LG++ +Y   Y+   L  +PR+  R  + L  ++  F+G D W  YE+SWLN+KG P
Sbjct: 15  QSELGQTANYDSYYNPKRLYPIPRAPKRQEINLDPNSTTFYGFDCWNHYEVSWLNSKGKP 74

Query: 72  QVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVAL 131
            VA+  +  D  S  +IESKS KLY NS N + F + + V QT+ +DLS C   +++V +
Sbjct: 75  VVAMAVISYDCHSPCIIESKSLKLYFNSLNNSTFPDVETVVQTISKDLSHCIGSEVAVNV 134

Query: 132 YRLDELEGQPIG-HFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNC 190
           Y L E+  Q I   F+G C+D  DI    Y    D+L  +    K+VEE L S LLKSNC
Sbjct: 135 YPLSEIASQTIYAAFDGICLDKLDIECSVYHVMPDFLSTS---SKLVEEVLYSDLLKSNC 191

Query: 191 LITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLS 250
           L+T+QPDWGS+QI Y+G++I+ E LL+YL+SFR+HNEFHEQC+ERIF D++RFCQPE L+
Sbjct: 192 LVTNQPDWGSVQIIYKGKKINHEGLLKYLISFRNHNEFHEQCIERIFADIMRFCQPESLA 251

Query: 251 VYARYTRRGGLDINPWRSNS--DFVPSTTRLVRQ 282
           VY RYTRRGGLDINP RS     F     RL+RQ
Sbjct: 252 VYGRYTRRGGLDINPIRSTEPCAFDGQNIRLIRQ 285


>UniRef50_Q6FA61 NADPH-dependent 7-cyano-7-deazaguanine reductase n=16
           Tax=Acinetobacter RepID=QUEF_ACIAD
          Length = 271

 Score =  329 bits (844), Expect = 6e-89,   Method: Composition-based stats.
 Identities = 120/277 (43%), Positives = 165/277 (59%), Gaps = 8/277 (2%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLG-LKADNLPFHGTDIWTLYELSWLN 66
            ++    LGK T+Y  TY  S+L  + R   R+    ++  +    G D W ++ELSWLN
Sbjct: 1   MSVEQSLLGKETEYPTTYSPSVLFPISRDAAREKYAQIEGIS---QGKDWWHVFELSWLN 57

Query: 67  AKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGK 126
           +  +PQVA+G + L  TS  LIESKS KLY NS N   F +  E+   +E+DLS  A  K
Sbjct: 58  SDNIPQVAIGRITLPATSPYLIESKSLKLYFNSLNFHVFASKQELIDLVEKDLSQAANAK 117

Query: 127 ISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLL 186
           +S+ L+ +D LE   I   +G CIDD              L+     +   + TL SHLL
Sbjct: 118 VSLELFDVDSLE---ISKPSGMCIDDLKPERLESHPDASLLKLDANEQHDADVTLYSHLL 174

Query: 187 KSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQP 246
           +SNC +T QPDWG++ I+Y GR+     +L Y++S+R HN FHEQCVE+I+ D+ +  QP
Sbjct: 175 RSNCPVTGQPDWGTVFIRYTGRKHCYRSILAYIISYRQHNGFHEQCVEQIYADIWKNLQP 234

Query: 247 EKLSVYARYTRRGGLDINPWR-SNSDFVPSTTRLVRQ 282
           EKL VYA YTRRGGLDINP R S+  ++P+  RL RQ
Sbjct: 235 EKLMVYATYTRRGGLDINPCRVSDLSWMPNPIRLARQ 271


>UniRef50_A8F0H9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=14
           Tax=Rickettsia RepID=QUEF_RICM5
          Length = 273

 Score =  323 bits (827), Expect = 6e-87,   Method: Composition-based stats.
 Identities = 120/277 (43%), Positives = 172/277 (62%), Gaps = 6/277 (2%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNA 67
             L+   LGK + Y+D+YD +LL  +PR  NR+ LG+ ++NLPF+G D+W  YELS LN 
Sbjct: 1   MPLSTSLLGKKSTYKDSYDVTLLFKIPRINNRNELGINSNNLPFYGVDVWNTYELSCLNK 60

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKI 127
            G P V VG   +   S N++ESKSFKLYLNSFN     +  E+ + + +DLS     K+
Sbjct: 61  NGKPWVGVGTFYIPTDSENIVESKSFKLYLNSFNNFVVESVKELERIILQDLSNVTHAKV 120

Query: 128 SVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLK 187
           +  ++ ++       G  +G  IDD DI  +NY    + L      + +VEE + S+LLK
Sbjct: 121 TGRIFPIN--TKVEFGVPSGKNIDDLDIVCNNYGAPDNSL--IEYEDVLVEEEINSNLLK 176

Query: 188 SNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           SNCL+T QPDWG++ I+Y+G+++  +  L+YL+SFR+ NEF EQC ERIF D+     P+
Sbjct: 177 SNCLVTGQPDWGTIVIKYKGKKLKHDSFLKYLISFRNCNEFAEQCAERIFTDIKNAISPD 236

Query: 248 KLSVYARYTRRGGLDINPWRSNSDF--VPSTTRLVRQ 282
            LS+   YTRRGG+DI P+RS      +PS  R +RQ
Sbjct: 237 FLSISIVYTRRGGIDICPYRSTDKSYTLPSDKRFIRQ 273


>UniRef50_B8KG68 NADPH-dependent 7-cyano-7-deazaguanine reductase (Nadph-dependent
           nitrile oxidoreductase) n=1 Tax=gamma proteobacterium
           NOR5-3 RepID=B8KG68_9GAMM
          Length = 276

 Score =  322 bits (826), Expect = 7e-87,   Method: Composition-based stats.
 Identities = 114/285 (40%), Positives = 157/285 (55%), Gaps = 12/285 (4%)

Query: 1   MSSYANHQALA---GLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIW 57
           M  + +   +A   G  LG+       YD  LL  VPR+  R  L          G DIW
Sbjct: 1   MGDHHSAPGVAHDKGPLLGRQVAGSHYYDPGLLFPVPRANARKSL--PGGAFAGFGEDIW 58

Query: 58  TLYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLER 117
             YELSWLNA G+PQ+ +G   +   S N+IESKSFKLYLNS N   F +    R+T+ R
Sbjct: 59  HAYELSWLNASGMPQMFLGTFSVPADSANIIESKSFKLYLNSLNNFEFASDGLARETIVR 118

Query: 118 DLSTCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVV 177
           DLS  A  ++S+ L  +D+          G C+D   +++   E   + LE      +V 
Sbjct: 119 DLSAVAGAQVSLVLKAVDDQRYDG-RVLEGDCLDGFQVSVPE-EPHVELLEPVVGDARVY 176

Query: 178 EETLVSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIF 237
                +HL++S C +T QPDW ++ I+ RG    R+KLL YL+++R+H EFHEQCVER++
Sbjct: 177 -----THLMRSLCPVTAQPDWATMIIETRGTSAQRDKLLSYLLAYRNHQEFHEQCVERVY 231

Query: 238 NDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
            DL +  +P+ LSV A YTRRGGLDI PWR +        R+ RQ
Sbjct: 232 TDLWKRLEPDYLSVQALYTRRGGLDICPWRCSEARPAPQGRMNRQ 276


>UniRef50_C8PYF2 Queuine synthase n=3 Tax=Moraxellaceae RepID=C8PYF2_9GAMM
          Length = 283

 Score =  316 bits (810), Expect = 5e-85,   Method: Composition-based stats.
 Identities = 118/275 (42%), Positives = 165/275 (60%), Gaps = 8/275 (2%)

Query: 15  LGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVA 74
           LG+ST Y  TY   +L  +PR+L R  L L AD L   G D W ++E+SWLN+ G+ QVA
Sbjct: 10  LGQSTSYPKTYAPDMLYPIPRALGRAKLALPADALSI-GMDWWQVFEMSWLNSHGISQVA 68

Query: 75  VGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRL 134
           +  + +  TS  ++ESKS KLY NS N T F+N   V+  +E+DLS C +  +++ ++ +
Sbjct: 69  MVRLAIPATSDYIVESKSLKLYFNSLNFTEFDNQQAVKAAVEKDLSACLKTDVTLEIFEV 128

Query: 135 DELEGQPIGHFNGTCIDDQ------DITIDNYEFTTDYLENATCGEKVVEETLVSHLLKS 188
           +     PI    G CID+        I I +   ++              + L SHLL+S
Sbjct: 129 NIANSLPISAPQGDCIDNALDNSGKKIAIVSDVDSSSLTVADQGASDSQLQILHSHLLRS 188

Query: 189 NCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEK 248
           NC +T+QPDWG+L+IQ   + IDR  LL Y++SFR HN FHEQCVE+IF+DL +   P+ 
Sbjct: 189 NCPVTNQPDWGTLEIQIDSQPIDRAGLLEYILSFRQHNGFHEQCVEQIFSDLTQAFAPKT 248

Query: 249 LSVYARYTRRGGLDINPWR-SNSDFVPSTTRLVRQ 282
           L V A YTRRGG+DINP R S+   +P  +RL RQ
Sbjct: 249 LMVRAWYTRRGGIDINPCRVSDISLLPPPSRLNRQ 283


>UniRef50_A4A3I6 GTP cyclohydrolase I n=1 Tax=Congregibacter litoralis KT71
           RepID=A4A3I6_9GAMM
          Length = 272

 Score =  313 bits (803), Expect = 4e-84,   Method: Composition-based stats.
 Identities = 118/272 (43%), Positives = 158/272 (58%), Gaps = 9/272 (3%)

Query: 11  AGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGL 70
            G  LG+     + YD SLL  VPRS  R  L          G DIW  YELSWL+A G+
Sbjct: 10  KGPLLGQQVVGSEQYDPSLLFPVPRSNARASL--PEQRFQGFGEDIWHAYELSWLSAAGM 67

Query: 71  PQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVA 130
           PQ  VG   +  TS NLIESKS KLYLNS N  RF + +  RQT+ RDLS  A   +S+ 
Sbjct: 68  PQAFVGTFAIPATSANLIESKSLKLYLNSLNNHRFTSAEAARQTIVRDLSEVAGAPVSLT 127

Query: 131 LYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNC 190
           L   ++   +      G+C+DD ++T+   +     L     G+ +    L +HL++S C
Sbjct: 128 LGSPEDPAFRG-EDLPGSCLDDLEVTVP--DAADPVLLTGVAGDGL----LYTHLMRSLC 180

Query: 191 LITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLS 250
            +T QPDW ++ ++ RG   +   LLRYL+++R+H EFHEQCVERI+ D+L   QP+ LS
Sbjct: 181 PVTAQPDWATVVVETRGVAPESPGLLRYLLAYRNHQEFHEQCVERIYTDILDRLQPDYLS 240

Query: 251 VYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           V+A YTRRGGLDI+PWR +        RL RQ
Sbjct: 241 VHALYTRRGGLDISPWRCSEHQPAPRYRLNRQ 272


>UniRef50_B8KRQ4 NADPH-dependent 7-cyano-7-deazaguanine reductase n=1 Tax=gamma
           proteobacterium NOR51-B RepID=B8KRQ4_9GAMM
          Length = 267

 Score =  308 bits (789), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 102/274 (37%), Positives = 140/274 (51%), Gaps = 8/274 (2%)

Query: 10  LAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKG 69
           +    LG   D    Y   +L+ V R    + L       P  G D+W LYELSWL+ +G
Sbjct: 1   MVDRVLGSRVDAPTRYSPEILEPVERQRGDERLS------PMLGADVWHLYELSWLSREG 54

Query: 70  LPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISV 129
            P   VG + +  +S   +ESKS KLYLNS N  RF+N      T+ RD+       + +
Sbjct: 55  WPTAFVGALAIPASSPRTVESKSLKLYLNSLNFHRFDNERAAVSTIMRDVQAVVGASVDL 114

Query: 130 ALYRLDELEGQPIGHFNGTCIDD-QDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKS 188
            +    EL  Q      G CIDD     +   ++        + GE  V ETL+SH L+S
Sbjct: 115 TIAAPTELA-QWTREPAGVCIDDVFSGALVAADWGASRKTPFSQGEDRVSETLISHQLRS 173

Query: 189 NCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEK 248
            C +T QPDWG+L + Y G ++D  +LL ++ SFR H +FHE CVE+I+  L     PE 
Sbjct: 174 LCPVTGQPDWGTLVVDYSGYRLDPAELLSFVCSFREHQDFHEHCVEQIYKKLFGDLSPEA 233

Query: 249 LSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           L+V A Y RRGG+DI PWR +        R+ RQ
Sbjct: 234 LTVTAYYQRRGGIDITPWRGHEKLDAPLWRMGRQ 267


>UniRef50_A0Z1W1 Putative uncharacterized protein n=1 Tax=marine gamma
           proteobacterium HTCC2080 RepID=A0Z1W1_9GAMM
          Length = 267

 Score =  305 bits (781), Expect = 1e-81,   Method: Composition-based stats.
 Identities = 103/273 (37%), Positives = 144/273 (52%), Gaps = 6/273 (2%)

Query: 10  LAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKG 69
           +A   LG+       Y   +L+ + R   R+ LG    ++   G D W LYELSWLN + 
Sbjct: 1   MAVHALGQKVAAPKRYAPDILEAISRREGREALGPAPKSM--VGHDCWHLYELSWLNLRN 58

Query: 70  LPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISV 129
            PQ  VG + +D  S   IESKS KLYLNS N   F +  +  + +  D+    Q  +S+
Sbjct: 59  EPQHCVGVLLVDSASPATIESKSLKLYLNSLNFHCFASEAQACEVICGDIGRVTQSDVSL 118

Query: 130 ALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSN 189
            +   D L         G  ++      D+    + +      G+ +++ T VSH L+S 
Sbjct: 119 TVLPPDGLGAI-TREPEGVLLEADPQQSDHTSMQSPW---CDSGDDILDATYVSHRLRSL 174

Query: 190 CLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKL 249
           C +T QPDWG+L I YRGR I+  +LL ++ SFR H EFHEQCVER F ++++    E L
Sbjct: 175 CPVTAQPDWGTLVIDYRGRPINHHRLLGFIESFREHQEFHEQCVERCFYEVMKQTNAESL 234

Query: 250 SVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
            V A Y RRGG+DI P RSN   VP   R+ RQ
Sbjct: 235 RVSAFYQRRGGIDITPVRSNHRVVPELWRMGRQ 267


>UniRef50_Q1QDK8 NADPH-dependent 7-cyano-7-deazaguanine reductase n=3
           Tax=Psychrobacter RepID=QUEF_PSYCK
          Length = 285

 Score =  304 bits (780), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 115/286 (40%), Positives = 167/286 (58%), Gaps = 12/286 (4%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNA 67
            ++ G+   ++TDY   Y    L  + RS+ R+ +G + D L   G D W  +ELSWLN 
Sbjct: 1   MSIHGILGEQTTDYPTEYSPETLYPIARSMGREVIGWQDDKLE-VGFDWWQAFELSWLNE 59

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKI 127
           +G+ QVA+    +  +S  ++ESKS KLYLNS N T F + + V+  + +DLS C Q ++
Sbjct: 60  QGISQVAIARFGIPASSPFIVESKSLKLYLNSINFTEFGSLETVQTLIAKDLSKCVQAEV 119

Query: 128 SVALYRL-DELEGQPIGHFNGTCIDDQ-----DITIDNYEFTTDYLENATCGEKVVEET- 180
           +V L+ L DE  G  I   +G CIDD      +            LE  T   K+ E   
Sbjct: 120 NVELFDLEDEHSGLLIAQPDGICIDDALADSTEKVALTLHPDASLLERNTSDAKISEGKT 179

Query: 181 --LVSHLLKSNCLITHQPDWGSLQIQYRG-RQIDREKLLRYLVSFRHHNEFHEQCVERIF 237
               S+LL+SNC +T+QPDWG+L +     + ++   +LRY++SFR HN FHEQCVE+IF
Sbjct: 180 FSFYSNLLRSNCPVTNQPDWGTLAVSITSNKPVNNANMLRYILSFRQHNGFHEQCVEQIF 239

Query: 238 NDLLRFCQPEKLSVYARYTRRGGLDINPWR-SNSDFVPSTTRLVRQ 282
            DL ++ +P +L V A YTRRGG+DINP R S+   +P  +RL+RQ
Sbjct: 240 ADLSQYYEPSELMVRAWYTRRGGIDINPCRVSDIALLPVPSRLIRQ 285


>UniRef50_P44165 Uncharacterized protein HI1340 n=9 Tax=Gammaproteobacteria
           RepID=Y1340_HAEIN
          Length = 441

 Score =  274 bits (701), Expect = 3e-72,   Method: Composition-based stats.
 Identities = 126/280 (45%), Positives = 168/280 (60%), Gaps = 16/280 (5%)

Query: 3   SYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYEL 62
           +Y +  +L  L LG+ T+Y   YD +LLQ VPR+LNRD LG+  +     G DIWT YE+
Sbjct: 2   NYQD-NSLKSLKLGQKTEYASQYDRTLLQPVPRALNRDGLGITQNQPFTIGADIWTAYEI 60

Query: 63  SWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTC 122
           SWLN KGLPQVA+  + LDY S NLIESKSFKLYLNSFNQ++F +++ V+QT++RDLS C
Sbjct: 61  SWLNEKGLPQVAIADIYLDYQSQNLIESKSFKLYLNSFNQSKFTDFNAVQQTMQRDLSEC 120

Query: 123 AQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLV 182
           AQG + V L  +   + Q I H  G CID+QDI I +YEF  ++L++    E +VEE LV
Sbjct: 121 AQGDVKVRLNPVAVYDAQKINHLQGDCIDEQDIEITSYEFNANWLKDCVSNE-IVEEKLV 179

Query: 183 SHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIF----N 238
           SHLLKSNCLIT+QPDWG+ Q Q         KL     +F    +  EQ +  +     N
Sbjct: 180 SHLLKSNCLITNQPDWGTDQAQQAILTARNNKL-----NFETQRKTAEQTLRNLLNLKPN 234

Query: 239 DLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTR 278
           + L    P  ++V        G+++N   S     P    
Sbjct: 235 EALNITFPHIMNVKT-----AGVNLNVPVSVIANRPDVKA 269


>UniRef50_Q6WI29 GTP cyclohydrolase I family protein n=1 Tax=Vibrio phage KVP40
           RepID=Q6WI29_BPKV4
          Length = 302

 Score =  269 bits (688), Expect = 7e-71,   Method: Composition-based stats.
 Identities = 99/288 (34%), Positives = 138/288 (47%), Gaps = 16/288 (5%)

Query: 1   MSSYANHQALAGLTLGKST-DYRDTYD-----ASLLQGVPRSLNRDPLGLKADNLPFHGT 54
           MS+Y    A+A   LGK   DY D  D       LL  +PR LNR   G+   N  F G 
Sbjct: 1   MSNYDQVSAIAAEHLGKKAGDYSDFVDIVEVRPDLLVPIPRELNRTDYGIT--NEDFAGF 58

Query: 55  DIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQ-----TRFNNWD 109
           D W  +E+S L  +GLP   +  V     S N++ESKS KLY NSFN      TR    D
Sbjct: 59  DTWHGFEVSALTEQGLPVSGMAKVVYPSDSPNIVESKSMKLYWNSFNMAKVAATRAEVKD 118

Query: 110 EVRQTLERDLSTCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLEN 169
            +     RDLS      + V+ +   E   QP G      +D        ++  +    +
Sbjct: 119 AIEAIASRDLSEVIGAPVQVSFFT--EKLTQPHGMTGFAELDKYVSESTVFDSESGADAD 176

Query: 170 ATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQIDR-EKLLRYLVSFRHHNEF 228
                 + +  + +  L+SNC +THQPD+G L +   G +    + L++Y+VSFR  N F
Sbjct: 177 LLQESHIKKLKVFTPNLRSNCRVTHQPDFGDLYVYMSGEKTPTVDSLMQYIVSFRKENHF 236

Query: 229 HEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPST 276
           HE+CVE I+  LL    P +L V A YTRRGG +I P R+  + +   
Sbjct: 237 HEECVEMIYKALLDKFDPTELMVTALYTRRGGWNICPARATHEELLPE 284


>UniRef50_B7RUV0 GTP cyclohydrolase I subfamily, putative n=1 Tax=marine gamma
           proteobacterium HTCC2148 RepID=B7RUV0_9GAMM
          Length = 168

 Score =  205 bits (521), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 77/172 (44%), Positives = 111/172 (64%), Gaps = 4/172 (2%)

Query: 111 VRQTLERDLSTCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENA 170
           +R+TL++D+       I + L  +D +E    G  +G CIDD  I+ID+     + L+  
Sbjct: 1   MRETLKKDIENTVGASIELELLPVDAVELDG-GIPDGLCIDDLQISIDSSPPGVNLLQA- 58

Query: 171 TCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHE 230
             GE++VEE + SHLL+S C +T QPDW ++ ++YRGR +  E LLRYL++FR H EFHE
Sbjct: 59  --GEELVEEAVYSHLLRSLCPVTGQPDWATVYVRYRGRALTHESLLRYLIAFRKHQEFHE 116

Query: 231 QCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           QCVER++ D+ +   PE L + A YTRRGGLDINP+RS+       +R+ RQ
Sbjct: 117 QCVERMYCDIHKLVSPEFLEIQAFYTRRGGLDINPFRSSDANPIPLSRMNRQ 168



 Score = 48.4 bits (114), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 16/98 (16%), Positives = 30/98 (30%), Gaps = 13/98 (13%)

Query: 50  PFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWD 109
                 +++    S     G P  A  +V         +  +S   YL +F + +  +  
Sbjct: 61  ELVEEAVYSHLLRSLCPVTGQPDWATVYVRY---RGRALTHESLLRYLIAFRKHQEFHEQ 117

Query: 110 EVRQTLERDLSTCAQGKISVALYRLDELEGQPIGHFNG 147
            V + +  D+           L   + LE Q      G
Sbjct: 118 CV-ERMYCDIHK---------LVSPEFLEIQAFYTRRG 145


>UniRef50_B8DRK9 7-cyano-7-deazaguanine reductase n=2 Tax=Desulfovibrio
           RepID=B8DRK9_DESVM
          Length = 188

 Score =  168 bits (426), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 24/136 (17%), Positives = 50/136 (36%), Gaps = 5/136 (3%)

Query: 152 DQDITIDNYEFTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG-- 207
                  +       LE       ++    ++      S C +T QPD+ ++  +Y    
Sbjct: 39  GVKAEYPHAGPGPHILEAFPNNFPDRPYIVSIAFPEFTSLCPVTGQPDFATIVTEYIPDQ 98

Query: 208 RQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWR 267
           R ++ +    Y+ ++R+H  F E     + + +     P    V   +T RGG  ++ + 
Sbjct: 99  RCVESKSFKLYMFAYRNHQSFMETITNTVLDHMTEALDPLWCRVKGLFTPRGGTHLHVFA 158

Query: 268 SNSDFVPSTT-RLVRQ 282
                V      +VR+
Sbjct: 159 ERFKQVEEPRAAMVRE 174



 Score =  123 bits (308), Expect = 9e-27,   Method: Composition-based stats.
 Identities = 24/149 (16%), Positives = 43/149 (28%), Gaps = 18/149 (12%)

Query: 2   SSYANHQALAGLT--LGKSTDYRDT-YDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWT 58
           ++Y   Q   G    LG   +Y        +L+  P +    P  +      F       
Sbjct: 23  AAYTRSQDQTGHLRTLGVKAEYPHAGPGPHILEAFPNNFPDRPYIVSIAFPEFT------ 76

Query: 59  LYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERD 118
               S     G P  A    E        +ESKSFKLY+ ++   +    + +  T+   
Sbjct: 77  ----SLCPVTGQPDFATIVTEYIPD-QRCVESKSFKLYMFAYRNHQSF-METITNTVLDH 130

Query: 119 LSTCAQG---KISVALYRLDELEGQPIGH 144
           ++        ++                 
Sbjct: 131 MTEALDPLWCRVKGLFTPRGGTHLHVFAE 159


>UniRef50_A9VKS1 NADPH-dependent 7-cyano-7-deazaguanine reductase n=310 Tax=Bacteria
           RepID=QUEF_BACWK
          Length = 165

 Score =  166 bits (420), Expect = 9e-40,   Method: Composition-based stats.
 Identities = 35/116 (30%), Positives = 59/116 (50%), Gaps = 4/116 (3%)

Query: 160 YEFTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKL 215
           +E++ + LE        +            S C  T QPD+ ++ I Y    R ++ + L
Sbjct: 24  FEYSPEILEVFDNNHPNRDYFVKFNCPEFTSLCPKTGQPDFATIYISYIPEQRMVESKSL 83

Query: 216 LRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSD 271
             YL SFR+H +FHE C+  I NDL++   P  + V+ ++T RGG+ I+P+ +   
Sbjct: 84  KLYLFSFRNHGDFHEDCMNVIMNDLIKLMDPRYIEVWGKFTPRGGISIDPYCNYGR 139



 Score =  129 bits (325), Expect = 8e-29,   Method: Composition-based stats.
 Identities = 26/134 (19%), Positives = 43/134 (32%), Gaps = 16/134 (11%)

Query: 13  LTLG-KSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLP 71
             LG ++T Y   Y   +L+    +       +K +   F           S     G P
Sbjct: 13  TLLGNQNTKYLFEYSPEILEVFDNNHPNRDYFVKFNCPEFT----------SLCPKTGQP 62

Query: 72  QVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQG---KIS 128
             A  ++        ++ESKS KLYL SF      + D +   +  DL         ++ 
Sbjct: 63  DFATIYISYIPE-QRMVESKSLKLYLFSFRNHGDFHEDCM-NVIMNDLIKLMDPRYIEVW 120

Query: 129 VALYRLDELEGQPI 142
                   +   P 
Sbjct: 121 GKFTPRGGISIDPY 134


>UniRef50_Q2IH01 NADPH-dependent 7-cyano-7-deazaguanine reductase n=5 Tax=Bacteria
           RepID=QUEF_ANADE
          Length = 122

 Score =  165 bits (419), Expect = 1e-39,   Method: Composition-based stats.
 Identities = 27/118 (22%), Positives = 48/118 (40%), Gaps = 4/118 (3%)

Query: 163 TTDYLENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRY 218
            +  L+        +  E  +        C +T QPD+ +++++Y    R ++ + L  Y
Sbjct: 5   PSRDLQTFPNPKPGRPFEIAMECPEFTCVCPMTGQPDFATIRLRYVPAERCVELKSLKLY 64

Query: 219 LVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPST 276
           L SFR    FHE    RI +DL+    P  + V   +  RGG+       + +     
Sbjct: 65  LWSFRDEGTFHEAVTNRICDDLVAALAPRWIEVVGDFAVRGGIHTVVTARHGERPAGV 122



 Score =  115 bits (289), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 21/119 (17%), Positives = 30/119 (25%), Gaps = 13/119 (10%)

Query: 22  RDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELD 81
                   LQ  P      P  +  +   F                 G P  A   +   
Sbjct: 2   PTQPSRD-LQTFPNPKPGRPFEIAMECPEFTCV----------CPMTGQPDFATIRLRYV 50

Query: 82  YTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRLDELEGQ 140
             +   +E KS KLYL SF      +   V   +  DL      +    +       G 
Sbjct: 51  P-AERCVELKSLKLYLWSFRDEGTFHE-AVTNRICDDLVAALAPRWIEVVGDFAVRGGI 107


>UniRef50_C7JB01 Queuosine biosynthesis protein QueF n=9 Tax=Alphaproteobacteria
           RepID=C7JB01_ACEP3
          Length = 178

 Score =  162 bits (411), Expect = 1e-38,   Method: Composition-based stats.
 Identities = 34/120 (28%), Positives = 51/120 (42%), Gaps = 4/120 (3%)

Query: 162 FTTDYLE--NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLR 217
                LE   A   +K       +    S C IT QPD+  + I Y   +  ++ + L  
Sbjct: 46  PEEAILERVPAPYPDKHYLVRFTAPEFTSLCPITGQPDFAHIVIDYVPDKWIVESKSLKL 105

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTT 277
           YL SFR+H  FHE C  +I N L+    P  L + A +  RGG+ I+ +    +      
Sbjct: 106 YLTSFRNHGAFHEACSIQIANTLVERLAPRWLRIGAYWYPRGGIPIDVFWQTGEPPAGVW 165



 Score =  123 bits (310), Expect = 5e-27,   Method: Composition-based stats.
 Identities = 29/161 (18%), Positives = 49/161 (30%), Gaps = 18/161 (11%)

Query: 1   MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLY 60
           M+   + +      LGK      + + ++L+ VP         ++     F         
Sbjct: 23  MTPADDGRD-QLTQLGKQVAAPQSPEEAILERVPAPYPDKHYLVRFTAPEFT-------- 73

Query: 61  ELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLS 120
             S     G P  A   ++       ++ESKS KLYL SF      +     Q     + 
Sbjct: 74  --SLCPITGQPDFAHIVIDYVPDK-WIVESKSLKLYLTSFRNHGAFHEACSIQIANTLVE 130

Query: 121 TCAQ--GKISVALYRLDELEGQPIGH----FNGTCIDDQDI 155
             A    +I    Y    +             G  +  QD+
Sbjct: 131 RLAPRWLRIGAYWYPRGGIPIDVFWQTGEPPAGVWVPAQDV 171


>UniRef50_Q3SJI1 NADPH-dependent 7-cyano-7-deazaguanine reductase n=9 Tax=Bacteria
           RepID=QUEF_THIDA
          Length = 139

 Score =  161 bits (407), Expect = 3e-38,   Method: Composition-based stats.
 Identities = 29/124 (23%), Positives = 47/124 (37%), Gaps = 7/124 (5%)

Query: 163 TTDYLENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRY 218
            +  LE        +     +        C  T QPD+ +L + Y      ++ + L  Y
Sbjct: 5   PSKTLETFPNPKPGRDFHIHMEVPEFTCLCPKTGQPDFATLVLDYIPNQACVELKSLKLY 64

Query: 219 LVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW---RSNSDFVPS 275
           + SFR    FHE    RI +DL+    P  + + A++  RGG+  N     R +      
Sbjct: 65  MWSFRDEGHFHEDVTNRILDDLVAATDPRYMRLTAKFYVRGGIFTNVVAEHRKDGWQPAP 124

Query: 276 TTRL 279
              L
Sbjct: 125 RVDL 128



 Score =  113 bits (282), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 20/119 (16%), Positives = 31/119 (26%), Gaps = 13/119 (10%)

Query: 22  RDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELD 81
             T     L+  P         +  +   F                 G P  A   ++  
Sbjct: 2   PSTPS-KTLETFPNPKPGRDFHIHMEVPEFTC----------LCPKTGQPDFATLVLDYI 50

Query: 82  YTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRLDELEGQ 140
                 +E KS KLY+ SF      + D V   +  DL      +      +     G 
Sbjct: 51  PN-QACVELKSLKLYMWSFRDEGHFHED-VTNRILDDLVAATDPRYMRLTAKFYVRGGI 107


>UniRef50_C4XPJ6 Putative uncharacterized protein n=1 Tax=Desulfovibrio magneticus
           RS-1 RepID=C4XPJ6_DESMR
          Length = 143

 Score =  160 bits (406), Expect = 4e-38,   Method: Composition-based stats.
 Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 4/110 (3%)

Query: 163 TTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRY 218
           T   LE       ++  + T  S    S C  T QPD+G++ I+Y      I+ + L  Y
Sbjct: 28  TPGLLETFPNAFPDRRYDITFASDEFTSLCPKTGQPDFGTITIRYVPDKLCIESKSLKLY 87

Query: 219 LVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRS 268
           L S+R    F E    RI +DL+  CQP  + V   +  RGG+ I+   +
Sbjct: 88  LFSYRDEGAFMETLTNRILDDLVEVCQPHHMEVTGDFAARGGITISVTAT 137



 Score =  135 bits (339), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 27/141 (19%), Positives = 38/141 (26%), Gaps = 13/141 (9%)

Query: 5   ANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSW 64
            +   L  L  G +T Y       LL+  P +       +   +  F           S 
Sbjct: 8   DDVSTLKTLGQG-ATVYPRNVTPGLLETFPNAFPDRRYDITFASDEFT----------SL 56

Query: 65  LNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQ 124
               G P      +         IESKS KLYL S+        + +   +  DL    Q
Sbjct: 57  CPKTGQPDFGTITIRYVPDK-LCIESKSLKLYLFSYRDEGAF-METLTNRILDDLVEVCQ 114

Query: 125 GKISVALYRLDELEGQPIGHF 145
                         G  I   
Sbjct: 115 PHHMEVTGDFAARGGITISVT 135


>UniRef50_Q0AAV5 NADPH-dependent 7-cyano-7-deazaguanine reductase n=11 Tax=Bacteria
           RepID=QUEF_ALHEH
          Length = 129

 Score =  160 bits (404), Expect = 6e-38,   Method: Composition-based stats.
 Identities = 29/121 (23%), Positives = 46/121 (38%), Gaps = 7/121 (5%)

Query: 167 LENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSF 222
           LE       E+     +        C  T QPD+ ++ + Y    R ++ + L  Y+ SF
Sbjct: 9   LETFPNPRPERDFVLHMRIPEFTCLCPKTGQPDFATIHLDYVPDERCVELKSLKLYMWSF 68

Query: 223 RHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSN---SDFVPSTTRL 279
           R    FHE     I +DL+R  +P  + V A +  RGG+       +            L
Sbjct: 69  RDQGAFHEAITNEILDDLVRATEPRYMKVTAEFYVRGGIYTTVVAEHRKPGWAPAPKVEL 128

Query: 280 V 280
            
Sbjct: 129 A 129



 Score =  110 bits (276), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 20/126 (15%), Positives = 33/126 (26%), Gaps = 16/126 (12%)

Query: 22  RDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELD 81
                   L+  P         L      F                 G P  A  H++  
Sbjct: 2   STQPSKD-LETFPNPRPERDFVLHMRIPEFTC----------LCPKTGQPDFATIHLDYV 50

Query: 82  YTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQG---KISVALYRLDELE 138
                 +E KS KLY+ SF      +   +   +  DL    +    K++   Y    + 
Sbjct: 51  PD-ERCVELKSLKLYMWSFRDQGAFHE-AITNEILDDLVRATEPRYMKVTAEFYVRGGIY 108

Query: 139 GQPIGH 144
              +  
Sbjct: 109 TTVVAE 114


>UniRef50_B3E3W5 7-cyano-7-deazaguanine reductase n=3 Tax=Proteobacteria
           RepID=B3E3W5_GEOLS
          Length = 144

 Score =  159 bits (403), Expect = 8e-38,   Method: Composition-based stats.
 Identities = 36/120 (30%), Positives = 53/120 (44%), Gaps = 2/120 (1%)

Query: 151 DDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--R 208
           D  D  +  +  +                 +        C +T QPD+G++ I Y+   R
Sbjct: 21  DAPDAGLLEWFPSPYVDPELNPCGCTGTLHISCPEFTCLCPMTGQPDFGTIIIDYQPDQR 80

Query: 209 QIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRS 268
            ++ + L  YL SFR H EFHE  V RI NDL++   P  L+V   +T RGG+   P   
Sbjct: 81  CVESKSLKLYLGSFRMHGEFHEAGVNRICNDLVKLLDPVWLTVKGEFTPRGGIPFWPTAE 140



 Score =  130 bits (328), Expect = 4e-29,   Method: Composition-based stats.
 Identities = 33/145 (22%), Positives = 46/145 (31%), Gaps = 11/145 (7%)

Query: 7   HQALAGLTLGKSTDYR-DTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSW- 64
           H+ L  L  GK+T Y  D  DA LL+  P       L          GT   +  E +  
Sbjct: 4   HEGLKTLGEGKATTYSYDAPDAGLLEWFPSPYVDPELNPCGC----TGTLHISCPEFTCL 59

Query: 65  LNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQ 124
               G P      ++        +ESKS KLYL SF      +   V   +  DL     
Sbjct: 60  CPMTGQPDFGTIIIDYQPD-QRCVESKSLKLYLGSFRMHGEFHEAGV-NRICNDLVKLLD 117

Query: 125 G---KISVALYRLDELEGQPIGHFN 146
                +         +   P   + 
Sbjct: 118 PVWLTVKGEFTPRGGIPFWPTAEYR 142


>UniRef50_B8IYG6 NADPH-dependent 7-cyano-7-deazaguanine reductase n=6
           Tax=Desulfovibrionaceae RepID=QUEF_DESDA
          Length = 167

 Score =  158 bits (401), Expect = 1e-37,   Method: Composition-based stats.
 Identities = 28/134 (20%), Positives = 51/134 (38%), Gaps = 6/134 (4%)

Query: 155 ITIDNYEFTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QI 210
           +T      +   LE       ++    ++      S C +T QPD G++ ++Y      +
Sbjct: 20  LTSPEGGPSVALLEAFPNCFPQRPYVISISFPEFTSLCPVTGQPDCGTITVEYIPDELCV 79

Query: 211 DREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNS 270
           + +    Y+ +FR+H  F E     +  DL     P    V   +  RGG  I+ +    
Sbjct: 80  ESKSFKLYMFAFRNHQSFMETITNNVLEDLRALLNPCWCRVKGLFAPRGGTRIHVFAEAF 139

Query: 271 D--FVPSTTRLVRQ 282
                   + LVR+
Sbjct: 140 KDGMPEEQSALVRE 153



 Score =  117 bits (294), Expect = 4e-25,   Method: Composition-based stats.
 Identities = 26/145 (17%), Positives = 41/145 (28%), Gaps = 15/145 (10%)

Query: 3   SYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYEL 62
           S    + L  L  G+ T        +LL+  P    + P  +      F           
Sbjct: 5   SQDQTRDLKVLGTGRLTSPEGGPSVALLEAFPNCFPQRPYVISISFPEFT---------- 54

Query: 63  SWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTC 122
           S     G P      VE        +ESKSFKLY+ +F   +    + +   +  DL   
Sbjct: 55  SLCPVTGQPDCGTITVEYIPD-ELCVESKSFKLYMFAFRNHQSF-METITNNVLEDLRAL 112

Query: 123 AQG---KISVALYRLDELEGQPIGH 144
                 ++                 
Sbjct: 113 LNPCWCRVKGLFAPRGGTRIHVFAE 137


>UniRef50_Q8UD54 NADPH-dependent 7-cyano-7-deazaguanine reductase n=45
           Tax=Alphaproteobacteria RepID=QUEF_AGRT5
          Length = 154

 Score =  157 bits (398), Expect = 3e-37,   Method: Composition-based stats.
 Identities = 31/120 (25%), Positives = 47/120 (39%), Gaps = 4/120 (3%)

Query: 162 FTTDYLENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLR 217
                LE    G           +    S C +T QPD+  + I Y      ++ + L  
Sbjct: 22  PEKAVLEKVPNGNAGTDYVVRFTAPEFTSLCPMTGQPDFAHIVIDYIPGDFLVESKSLKL 81

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTT 277
           +L SFR+H  FHE C   I   L+   QP+ L + A +  RGG+ I+ +           
Sbjct: 82  FLQSFRNHGAFHEDCSVYIAKRLVELLQPKWLRIGAYWYPRGGIPIDVFWQTGAAPEGVW 141



 Score =  125 bits (315), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 29/145 (20%), Positives = 47/145 (32%), Gaps = 23/145 (15%)

Query: 3   SYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYEL 62
           S  +   L+   LG   D  ++ + ++L+ VP         ++     F           
Sbjct: 2   SVTDVSGLSQ--LGTKVDTPESPEKAVLEKVPNGNAGTDYVVRFTAPEFT---------- 49

Query: 63  SWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTC 122
           S     G P  A   ++       L+ESKS KL+L SF      + D      +R     
Sbjct: 50  SLCPMTGQPDFAHIVIDYIP-GDFLVESKSLKLFLQSFRNHGAFHEDCSVYIAKR----- 103

Query: 123 AQGKISVALYRLDELEGQPIGHFNG 147
                 V L +   L      +  G
Sbjct: 104 -----LVELLQPKWLRIGAYWYPRG 123


>UniRef50_A1WY83 NADPH-dependent 7-cyano-7-deazaguanine reductase n=5 Tax=Bacteria
           RepID=QUEF_HALHL
          Length = 118

 Score =  157 bits (396), Expect = 5e-37,   Method: Composition-based stats.
 Identities = 26/114 (22%), Positives = 45/114 (39%), Gaps = 4/114 (3%)

Query: 163 TTDYLENA--TCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRY 218
            +  LE       E+     +        C  T QPD+ +L ++Y      ++ + L  Y
Sbjct: 5   PSKTLETFENPNPERDYTIRMEIPEFTCLCPKTGQPDFATLNLEYIPERHCVELKSLKLY 64

Query: 219 LVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDF 272
           + S+R    FHE    +I  DL+   QP  + + A +  RGG+       +   
Sbjct: 65  IWSYRDVGGFHEALTNQILGDLVAATQPRYMKLTAHFNVRGGIWTTVEAEHHGR 118



 Score =  109 bits (273), Expect = 9e-23,   Method: Composition-based stats.
 Identities = 17/113 (15%), Positives = 32/113 (28%), Gaps = 12/113 (10%)

Query: 30  LQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIE 89
           L+            ++ +   F                 G P  A  ++E      + +E
Sbjct: 9   LETFENPNPERDYTIRMEIPEFTC----------LCPKTGQPDFATLNLEYIPER-HCVE 57

Query: 90  SKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRLDELEGQPI 142
            KS KLY+ S+      +   +   +  DL    Q +        +   G   
Sbjct: 58  LKSLKLYIWSYRDVGGFHE-ALTNQILGDLVAATQPRYMKLTAHFNVRGGIWT 109


>UniRef50_Q8GJN6 NADPH-dependent 7-cyano-7-deazaguanine reductase n=98 Tax=cellular
           organisms RepID=QUEF_SYNE7
          Length = 174

 Score =  156 bits (395), Expect = 8e-37,   Method: Composition-based stats.
 Identities = 31/120 (25%), Positives = 48/120 (40%), Gaps = 4/120 (3%)

Query: 162 FTTDYLENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLR 217
                LE       ++      V+    S C +T QPD+  L + Y   Q  ++ + L  
Sbjct: 42  PEVAVLETFDNPHPDRQYLVRFVAPEFTSLCPLTGQPDFAHLVLDYVPDQRLVESKSLKL 101

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTT 277
           +L SFR+H  FHE C   I   L     P  L +   +  RGGL I+ +  + +      
Sbjct: 102 FLGSFRNHGAFHENCTLTIAKRLEEAMNPTWLRLGGYWYPRGGLPIDVFYQSGEPPAGVW 161



 Score =  130 bits (326), Expect = 8e-29,   Method: Composition-based stats.
 Identities = 25/164 (15%), Positives = 44/164 (26%), Gaps = 23/164 (14%)

Query: 3   SYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYEL 62
           S           LG+      + + ++L+            ++     F           
Sbjct: 20  SLQKFMTETLTQLGQMVGLPASPEVAVLETFDNPHPDRQYLVRFVAPEFT---------- 69

Query: 63  SWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTC 122
           S     G P  A   ++       L+ESKS KL+L SF      + +    T+ + L   
Sbjct: 70  SLCPLTGQPDFAHLVLDYVPD-QRLVESKSLKLFLGSFRNHGAFHENCTL-TIAKRLEEA 127

Query: 123 AQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDY 166
                         L      +  G      D+   + E     
Sbjct: 128 MN---------PTWLRLGGYWYPRGGL--PIDVFYQSGEPPAGV 160


>UniRef50_D2L9R9 7-cyano-7-deazaguanine reductase n=1 Tax=Desulfovibrio sp. FW1012B
           RepID=D2L9R9_9DELT
          Length = 145

 Score =  156 bits (394), Expect = 9e-37,   Method: Composition-based stats.
 Identities = 35/114 (30%), Positives = 49/114 (42%), Gaps = 4/114 (3%)

Query: 163 TTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRY 218
           T   LE        +    T  S    S C  T QPD+G + I+Y    R I+ + L  Y
Sbjct: 32  TPGLLETFPNAFPGRRYTVTFASEEFTSLCPKTGQPDFGMITIRYVPDERCIESKSLKLY 91

Query: 219 LVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDF 272
           L S+R    F E    RI +DL+  CQP ++ V   +  RGG+ I+        
Sbjct: 92  LFSYRDEGTFMETLTNRILDDLVAACQPLEMEVTGDFAARGGITISVTAGYVKE 145



 Score =  140 bits (352), Expect = 8e-32,   Method: Composition-based stats.
 Identities = 29/143 (20%), Positives = 41/143 (28%), Gaps = 13/143 (9%)

Query: 5   ANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSW 64
            +   L  L  G +T Y  T    LL+  P +       +   +  F           S 
Sbjct: 12  DDVSTLTTLGQG-ATAYPRTVTPGLLETFPNAFPGRRYTVTFASEEFT----------SL 60

Query: 65  LNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQ 124
               G P   +  +         IESKS KLYL S+        + +   +  DL    Q
Sbjct: 61  CPKTGQPDFGMITIRYVPD-ERCIESKSLKLYLFSYRDEG-TFMETLTNRILDDLVAACQ 118

Query: 125 GKISVALYRLDELEGQPIGHFNG 147
                         G  I    G
Sbjct: 119 PLEMEVTGDFAARGGITISVTAG 141


>UniRef50_C7M0Q2 7-cyano-7-deazaguanine reductase n=1 Tax=Acidimicrobium
           ferrooxidans DSM 10331 RepID=C7M0Q2_ACIFD
          Length = 155

 Score =  156 bits (394), Expect = 1e-36,   Method: Composition-based stats.
 Identities = 39/127 (30%), Positives = 57/127 (44%), Gaps = 7/127 (5%)

Query: 161 EFTTDYLENATCGEKV--VEETLVSHLLKSNCLITHQPDWGSLQIQYR--GRQIDREKLL 216
           +     LE     +    +   L +    S C +T QPD+G L I Y    R ++ + L 
Sbjct: 21  DPDPSVLETFPTPQPSGGLVIRLFALEFTSLCPVTGQPDYGQLDIVYVPGPRCVESKSLK 80

Query: 217 RYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRS---NSDFV 273
            YL+ FR+H  FHE CV ++  DL     P  L V  R+  RGG+ I P R    + +  
Sbjct: 81  LYLMRFRNHGAFHEACVAQVAQDLASVLAPRYLRVIGRFNARGGIAIWPLREVVADHEDP 140

Query: 274 PSTTRLV 280
            +   LV
Sbjct: 141 AALRALV 147



 Score =  141 bits (355), Expect = 3e-32,   Method: Composition-based stats.
 Identities = 34/172 (19%), Positives = 53/172 (30%), Gaps = 18/172 (10%)

Query: 5   ANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSW 64
            +   L  L   + T   D  D S+L+  P       L ++   L F           S 
Sbjct: 2   DDSITLQALGSSRQTYAYDDPDPSVLETFPTPQPSGGLVIRLFALEFT----------SL 51

Query: 65  LNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQ 124
               G P      +         +ESKS KLYL  F      +   V Q + +DL++   
Sbjct: 52  CPVTGQPDYGQLDIVYVP-GPRCVESKSLKLYLMRFRNHGAFHEACVAQ-VAQDLASVLA 109

Query: 125 GKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKV 176
            +    + R +   G  I        D +D            L +   G + 
Sbjct: 110 PRYLRVIGRFNARGGIAIWPLREVVADHEDPAALRA------LVDLDNGARP 155


>UniRef50_A6C8E2 Putative uncharacterized protein n=2 Tax=Planctomycetaceae
           RepID=A6C8E2_9PLAN
          Length = 121

 Score =  155 bits (393), Expect = 1e-36,   Method: Composition-based stats.
 Identities = 32/120 (26%), Positives = 51/120 (42%), Gaps = 4/120 (3%)

Query: 158 DNYEFTTDYLENATCGE--KVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQI--DRE 213
              E + + LE        +      V     S C  T QPD+G+L I Y   ++  + +
Sbjct: 2   SENEASRELLETFENPHPHRDYVMETVCPEFTSVCPKTGQPDYGTLIITYIPDKVCFELK 61

Query: 214 KLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFV 273
            L  YL S+R+   F+E    RI +DL+    P  + + A +T RGG+      S+    
Sbjct: 62  SLKMYLQSYRNVGAFYEDVTNRILDDLVAITDPRWMELRAEFTPRGGISSTVTVSHHKED 121



 Score = 98.5 bits (244), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 20/120 (16%), Positives = 30/120 (25%), Gaps = 21/120 (17%)

Query: 28  SLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNL 87
            LL+            ++     F           S     G P      +      V  
Sbjct: 9   ELLETFENPHPHRDYVMETVCPEFT----------SVCPKTGQPDYGTLIITYIPDKV-C 57

Query: 88  IESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRLDELEGQPIGHFNG 147
            E KS K+YL S+        D V   +  DL           +     +E +      G
Sbjct: 58  FELKSLKMYLQSYRNVGAFYED-VTNRILDDLVA---------ITDPRWMELRAEFTPRG 107


>UniRef50_Q2LTJ0 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2 Tax=Bacteria
           RepID=QUEF_SYNAS
          Length = 140

 Score =  154 bits (390), Expect = 3e-36,   Method: Composition-based stats.
 Identities = 28/113 (24%), Positives = 44/113 (38%), Gaps = 4/113 (3%)

Query: 163 TTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRY 218
            +  LE       ++    T+ +      C +T QPD+  L I Y      ++ + L  Y
Sbjct: 22  PSRKLETFPNRHPDRDYIVTMETAEFTCVCPMTGQPDFADLHISYIPDASILESKSLKLY 81

Query: 219 LVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSD 271
           L S+R+   FHE     I  D++    P    V A +  RGG+ I        
Sbjct: 82  LWSYRNEGIFHEHVTNVILEDVVAALSPRWCKVTANFGVRGGISITVEAEYKK 134



 Score =  110 bits (274), Expect = 8e-23,   Method: Composition-based stats.
 Identities = 22/130 (16%), Positives = 36/130 (27%), Gaps = 17/130 (13%)

Query: 13  LTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQ 72
             LG+            L+  P         +  +   F                 G P 
Sbjct: 14  TLLGREAKPSRK-----LETFPNRHPDRDYIVTMETAEFTCV----------CPMTGQPD 58

Query: 73  VAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALY 132
            A  H+     + +++ESKS KLYL S+      +   V   +  D+      +      
Sbjct: 59  FADLHISYIPDA-SILESKSLKLYLWSYRNEGIFHEH-VTNVILEDVVAALSPRWCKVTA 116

Query: 133 RLDELEGQPI 142
                 G  I
Sbjct: 117 NFGVRGGISI 126


>UniRef50_Q9ZJJ9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=12
           Tax=Helicobacter RepID=QUEF_HELPJ
          Length = 148

 Score =  153 bits (387), Expect = 6e-36,   Method: Composition-based stats.
 Identities = 38/112 (33%), Positives = 60/112 (53%), Gaps = 4/112 (3%)

Query: 160 YEFTTDYLENATCGEKVVE--ETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKL 215
           +E+ +D LE        ++   TL      S C IT QPD+G + I+Y  +   ++ + L
Sbjct: 18  FEYNSDLLEAFPNPNPNLDPLITLECKEFTSLCPITSQPDFGVIFIRYIPKDKMVESKSL 77

Query: 216 LRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWR 267
             YL S+R+H  FHE C+  I  DL++  +P+ L VY  +  RGG+ I P+ 
Sbjct: 78  KLYLFSYRNHGSFHESCINTILLDLVQLLEPKYLEVYGDFVSRGGIAIKPFV 129



 Score =  120 bits (301), Expect = 6e-26,   Method: Composition-based stats.
 Identities = 28/131 (21%), Positives = 41/131 (31%), Gaps = 12/131 (9%)

Query: 15  LGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVA 74
           LG  T Y   Y++ LL+  P         +  +   F           S       P   
Sbjct: 10  LGAKTPYIFEYNSDLLEAFPNPNPNLDPLITLECKEFT----------SLCPITSQPDFG 59

Query: 75  VGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRL 134
           V  +        ++ESKS KLYL S+      +   +  T+  DL    + K        
Sbjct: 60  VIFIRYIP-KDKMVESKSLKLYLFSYRNHGSFHESCI-NTILLDLVQLLEPKYLEVYGDF 117

Query: 135 DELEGQPIGHF 145
               G  I  F
Sbjct: 118 VSRGGIAIKPF 128


>UniRef50_Q6MRJ2 NADPH-dependent 7-cyano-7-deazaguanine reductase n=1
           Tax=Bdellovibrio bacteriovorus RepID=QUEF_BDEBA
          Length = 170

 Score =  152 bits (384), Expect = 1e-35,   Method: Composition-based stats.
 Identities = 36/116 (31%), Positives = 59/116 (50%), Gaps = 4/116 (3%)

Query: 162 FTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLR 217
           +  + LE        K+   T V     S C  T QPD+  + I Y   +  ++ + L  
Sbjct: 28  YAPEVLEAFDNKNPGKIAWTTFVCTEFTSLCPKTRQPDFAKIFINYIADKKMVESKSLKL 87

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFV 273
           YL SFR+H +FHE CV+ I +DL++  +P+ + V   +T RGG+ I P+ + +   
Sbjct: 88  YLFSFRNHGDFHEDCVQTICDDLVKLMKPKYIEVIGEFTPRGGIAIYPYANYAAKD 143



 Score =  134 bits (338), Expect = 3e-30,   Method: Composition-based stats.
 Identities = 32/142 (22%), Positives = 47/142 (33%), Gaps = 13/142 (9%)

Query: 3   SYANHQALAGLTLGK-STDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYE 61
           +  + + LA   LG+  T+Y +TY   +L+                   F          
Sbjct: 5   NGRDSKELADFALGESQTNYPETYAPEVLEAFDNKNPGKIAWTTFVCTEFT--------- 55

Query: 62  LSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLST 121
            S       P  A   +        ++ESKS KLYL SF      + D V QT+  DL  
Sbjct: 56  -SLCPKTRQPDFAKIFINYIADK-KMVESKSLKLYLFSFRNHGDFHEDCV-QTICDDLVK 112

Query: 122 CAQGKISVALYRLDELEGQPIG 143
             + K    +       G  I 
Sbjct: 113 LMKPKYIEVIGEFTPRGGIAIY 134


>UniRef50_D1N404 7-cyano-7-deazaguanine reductase n=3 Tax=Bacteria
           RepID=D1N404_9BACT
          Length = 142

 Score =  149 bits (376), Expect = 1e-34,   Method: Composition-based stats.
 Identities = 33/116 (28%), Positives = 51/116 (43%), Gaps = 4/116 (3%)

Query: 160 YEFTTDYLENA--TCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKL 215
                  LE       ++            S C +T QPD+G + ++Y      I+ + L
Sbjct: 24  TRPEEARLEAFRNVYADRDYIIEFDCPEYTSLCPVTGQPDFGHIILRYVPDKLCIESKSL 83

Query: 216 LRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSD 271
             YL SFR+ N FHE+ V  I + +++ C P K  V  R+  RGG+ IN   +   
Sbjct: 84  KLYLYSFRNTNTFHEESVNTILDAVVKTCAPRKAEVIGRFRPRGGIAINVKATYGG 139



 Score =  120 bits (301), Expect = 6e-26,   Method: Composition-based stats.
 Identities = 24/131 (18%), Positives = 40/131 (30%), Gaps = 13/131 (9%)

Query: 20  DYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVE 79
           +Y    + + L+            ++ D   +           S     G P      + 
Sbjct: 21  NYPTRPEEARLEAFRNVYADRDYIIEFDCPEYT----------SLCPVTGQPDFGHIILR 70

Query: 80  LDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQ--GKISVALYRLDEL 137
                   IESKS KLYL SF  T   + + V   L+  + TCA    ++         +
Sbjct: 71  YVPDK-LCIESKSLKLYLYSFRNTNTFHEESVNTILDAVVKTCAPRKAEVIGRFRPRGGI 129

Query: 138 EGQPIGHFNGT 148
                  + G 
Sbjct: 130 AINVKATYGGA 140


>UniRef50_B2UN89 7-cyano-7-deazaguanine reductase n=2 Tax=Verrucomicrobiaceae
           RepID=B2UN89_AKKM8
          Length = 136

 Score =  148 bits (375), Expect = 2e-34,   Method: Composition-based stats.
 Identities = 36/123 (29%), Positives = 56/123 (45%), Gaps = 6/123 (4%)

Query: 160 YEFTTDYLENATC-GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLL 216
                  LE+    G +    TL +H   S C +T QPD   L I Y    + ++ + L 
Sbjct: 17  TNPDDARLESFPNRGTRPYTITLDTHEFSSLCPVTGQPDSCHLTITYVPAEKCVETKSLK 76

Query: 217 RYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPST 276
            YL ++R++  F+EQ V RI +DL+    P  L V  R++ RGG+ +     +    P  
Sbjct: 77  YYLAAYRNYPAFNEQIVNRITDDLVAAISPRWLKVEGRFSPRGGIQLTATAEH---NPEN 133

Query: 277 TRL 279
             L
Sbjct: 134 RPL 136



 Score =  108 bits (270), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 24/143 (16%), Positives = 41/143 (28%), Gaps = 20/143 (13%)

Query: 5   ANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSW 64
            +H  L    LG  + +    D + L+  P    R P  +  D   F           S 
Sbjct: 3   DDHLTL----LGSQSSFFTNPDDARLESFPNRGTR-PYTITLDTHEFS----------SL 47

Query: 65  LNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQ 124
               G P      +     +   +E+KS K YL ++      N   +   +  DL     
Sbjct: 48  CPVTGQPDSCHLTITYVP-AEKCVETKSLKYYLAAYRNYPAFNEQ-IVNRITDDLVAAIS 105

Query: 125 G---KISVALYRLDELEGQPIGH 144
               K+         ++      
Sbjct: 106 PRWLKVEGRFSPRGGIQLTATAE 128


>UniRef50_B3QM19 NADPH-dependent 7-cyano-7-deazaguanine reductase n=4 Tax=Bacteria
           RepID=QUEF_CHLP8
          Length = 116

 Score =  148 bits (373), Expect = 3e-34,   Method: Composition-based stats.
 Identities = 27/111 (24%), Positives = 47/111 (42%), Gaps = 4/111 (3%)

Query: 162 FTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLR 217
              + +E        +     +V+    S C  T  PD+G++ I Y      I+ + L  
Sbjct: 1   MNKEIIEVFDNTFPNRDYTIEIVNPEFTSVCPKTGLPDFGTITITYVPDKSCIELKSLKY 60

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRS 268
           Y + FR+   F+E     I + L+  CQP+ ++V   +  RGG+      S
Sbjct: 61  YFLEFRNAGIFYENITNTILDHLVEACQPKSMTVKTDWNARGGITETVTVS 111



 Score =  101 bits (253), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 18/116 (15%), Positives = 31/116 (26%), Gaps = 12/116 (10%)

Query: 26  DASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSV 85
           +  +++    +       ++  N  F           S     GLP      +       
Sbjct: 2   NKEIIEVFDNTFPNRDYTIEIVNPEFT----------SVCPKTGLPDFGTITITYVPDK- 50

Query: 86  NLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRLDELEGQP 141
           + IE KS K Y   F        + +  T+   L    Q K        +   G  
Sbjct: 51  SCIELKSLKYYFLEFRNAGIFYEN-ITNTILDHLVEACQPKSMTVKTDWNARGGIT 105


>UniRef50_B7J648 NADPH-dependent 7-cyano-7-deazaguanine reductase n=22 Tax=Bacteria
           RepID=QUEF_ACIF2
          Length = 141

 Score =  146 bits (369), Expect = 8e-34,   Method: Composition-based stats.
 Identities = 30/120 (25%), Positives = 46/120 (38%), Gaps = 7/120 (5%)

Query: 163 TTDYLENA--TCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRY 218
            +  LE       E+     +        C +T QPD+    + +   Q  ++ + L  Y
Sbjct: 5   PSRELERFSNPHPERDYVVHMDLPEFTCLCPLTGQPDFAHFMLDFIPDQHNVELKSLKLY 64

Query: 219 LVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW---RSNSDFVPS 275
           L SFR    FHE    RI +DL+    P  L +  R+  RGG+  +     R      P 
Sbjct: 65  LWSFRDEGAFHEAMTNRIADDLIGLINPRYLRLLGRWYVRGGITTDVLIEHRQPGWQNPD 124



 Score =  101 bits (251), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 21/124 (16%), Positives = 30/124 (24%), Gaps = 13/124 (10%)

Query: 22  RDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELD 81
                   L+            +  D   F                 G P  A   ++  
Sbjct: 2   PSQPSRE-LERFSNPHPERDYVVHMDLPEFTC----------LCPLTGQPDFAHFMLDFI 50

Query: 82  YTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRLDELEGQP 141
               N +E KS KLYL SF      +   +   +  DL      +    L R     G  
Sbjct: 51  PDQHN-VELKSLKLYLWSFRDEGAFHE-AMTNRIADDLIGLINPRYLRLLGRWYVRGGIT 108

Query: 142 IGHF 145
               
Sbjct: 109 TDVL 112


>UniRef50_B3EMR0 NADPH-dependent 7-cyano-7-deazaguanine reductase n=9 Tax=Bacteria
           RepID=QUEF_CHLPB
          Length = 118

 Score =  145 bits (367), Expect = 1e-33,   Method: Composition-based stats.
 Identities = 28/114 (24%), Positives = 49/114 (42%), Gaps = 4/114 (3%)

Query: 162 FTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLR 217
              + LE       ++     +V+    S C IT  PD+G++ I+Y      ++ + L  
Sbjct: 1   MQKELLEVFDNRFPDRDYTIEIVNPEFTSVCPITGLPDFGTITIRYIPDKVCVELKSLKY 60

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSD 271
           Y + FR+   F+E     I + L+   +P  L+V   +  RGG+      S S 
Sbjct: 61  YYLEFRNAGIFYENVTNTILDHLVDLLKPRTLTVTTAWKARGGITETVTVSYSA 114



 Score = 98.9 bits (245), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 19/114 (16%), Positives = 28/114 (24%), Gaps = 12/114 (10%)

Query: 28  SLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNL 87
            LL+            ++  N  F           S     GLP      +      V  
Sbjct: 4   ELLEVFDNRFPDRDYTIEIVNPEFT----------SVCPITGLPDFGTITIRYIPDKV-C 52

Query: 88  IESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRLDELEGQP 141
           +E KS K Y   F        + V  T+   L    + +            G  
Sbjct: 53  VELKSLKYYYLEFRNAGIFYEN-VTNTILDHLVDLLKPRTLTVTTAWKARGGIT 105


>UniRef50_Q8DMA3 NADPH-dependent 7-cyano-7-deazaguanine reductase n=14 Tax=Bacteria
           RepID=QUEF_THEEB
          Length = 132

 Score =  145 bits (366), Expect = 2e-33,   Method: Composition-based stats.
 Identities = 18/110 (16%), Positives = 41/110 (37%), Gaps = 2/110 (1%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHN 226
                 +     +        C  +  PD+ +L + Y    + ++ + +  Y+ S+R   
Sbjct: 22  PNPRPGRQYTIEITLPEFTCKCPFSGYPDFATLYVSYIPHEKVVELKAIKLYINSYRDRY 81

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPST 276
             HE+ V ++ +DL+  C P  + +   +  RG +       +     S 
Sbjct: 82  ISHEEAVNQVLDDLVAACDPLYMKIKGDFAPRGNVHTVITVEHHRQTESL 131



 Score = 96.6 bits (239), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 21/139 (15%), Positives = 40/139 (28%), Gaps = 18/139 (12%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNA 67
             ++ +  G+            L   P         ++     F                
Sbjct: 1   MQVSEMKYGERA-----IQEGQLITFPNPRPGRQYTIEITLPEFTCK----------CPF 45

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQG-- 125
            G P  A  +V        ++E K+ KLY+NS+     ++ + V Q L+  ++ C     
Sbjct: 46  SGYPDFATLYVSYIPH-EKVVELKAIKLYINSYRDRYISHEEAVNQVLDDLVAACDPLYM 104

Query: 126 KISVALYRLDELEGQPIGH 144
           KI         +       
Sbjct: 105 KIKGDFAPRGNVHTVITVE 123


>UniRef50_B8HRW7 7-cyano-7-deazaguanine reductase n=2 Tax=Cyanobacteria
           RepID=B8HRW7_CYAP4
          Length = 142

 Score =  145 bits (365), Expect = 2e-33,   Method: Composition-based stats.
 Identities = 23/130 (17%), Positives = 49/130 (37%), Gaps = 4/130 (3%)

Query: 146 NGTCIDDQDITIDNYEFTTDYLENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQI 203
           +GT     ++     +     L         +     +        C  +  PD+ ++ +
Sbjct: 12  DGTIAISTELKYGERQIQEGQLITFPNPRPGRRYTIQITLPEFTCKCPFSGYPDFATIHV 71

Query: 204 QYRGRQ--IDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGL 261
            Y   Q  ++ + +  Y+ S+R     HE+ V +I +DL+  C P ++SV   +  RG +
Sbjct: 72  SYIPDQRVVELKAIKLYINSYRDRYISHEESVNQILDDLVTACDPLQISVKGDFAPRGNV 131

Query: 262 DINPWRSNSD 271
                  +  
Sbjct: 132 HTVIEVEHQK 141



 Score =  104 bits (259), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 22/108 (20%), Positives = 36/108 (33%), Gaps = 11/108 (10%)

Query: 23  DTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDY 82
                  L   P         ++     F                 G P  A  HV    
Sbjct: 26  RQIQEGQLITFPNPRPGRRYTIQITLPEFTCK----------CPFSGYPDFATIHVSYIP 75

Query: 83  TSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVA 130
               ++E K+ KLY+NS+     ++ + V Q L+  ++ C   +ISV 
Sbjct: 76  D-QRVVELKAIKLYINSYRDRYISHEESVNQILDDLVTACDPLQISVK 122


>UniRef50_Q04RM8 NADPH-dependent 7-cyano-7-deazaguanine reductase n=6 Tax=Leptospira
           RepID=QUEF_LEPBJ
          Length = 133

 Score =  145 bits (365), Expect = 2e-33,   Method: Composition-based stats.
 Identities = 27/105 (25%), Positives = 42/105 (40%), Gaps = 2/105 (1%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHN 226
                 K            + C  T  PD+G + + Y    R I+ +    Y++S+R+  
Sbjct: 28  TNVYEGKDYTIDFTVPEFTAVCPKTGLPDFGVIYVSYVPTKRCIELKSFKEYILSYRNVG 87

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSD 271
            FHE  V +I  DL+    P+ L V   Y  RGG+     R  + 
Sbjct: 88  VFHEFLVNKIMEDLIAAIDPKYLKVIGDYNARGGIKTVVTREYNK 132



 Score =  102 bits (254), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 26/139 (18%), Positives = 39/139 (28%), Gaps = 22/139 (15%)

Query: 18  STDYRDTYD------ASL----LQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNA 67
            T++ +TYD       SL    ++            +      F                
Sbjct: 2   KTNHPETYDGRQDHIPSLKTPEIESFTNVYEGKDYTIDFTVPEFTAV----------CPK 51

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKI 127
            GLP   V +V    T    IE KSFK Y+ S+      +   V   +  DL      K 
Sbjct: 52  TGLPDFGVIYVSYVPTK-RCIELKSFKEYILSYRNVGVFHEFLV-NKIMEDLIAAIDPKY 109

Query: 128 SVALYRLDELEGQPIGHFN 146
              +   +   G       
Sbjct: 110 LKVIGDYNARGGIKTVVTR 128


>UniRef50_A8ZUH0 GTP cyclohydrolase I n=2 Tax=Desulfobacteraceae RepID=A8ZUH0_DESOH
          Length = 134

 Score =  142 bits (358), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 30/109 (27%), Positives = 51/109 (46%), Gaps = 2/109 (1%)

Query: 166 YLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFR 223
            +E A    + ++  +      S C +T  PD+G + I+YR R   ++ + L  YL+ +R
Sbjct: 26  VIEYAYRETRPIDVVIRQPEFTSLCPMTGLPDYGCITIRYRPRHHIVELKSLKYYLLQYR 85

Query: 224 HHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDF 272
           +   F+E  + RI NDL     P  + V   +T RGG+      +  D 
Sbjct: 86  NVGIFYEHVINRILNDLSGAVAPVWMEVSGEFTARGGITTTVTAATGDQ 134



 Score = 73.8 bits (180), Expect = 5e-12,   Method: Composition-based stats.
 Identities = 17/110 (15%), Positives = 28/110 (25%), Gaps = 15/110 (13%)

Query: 40  DPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNS 99
            P+ +      F           S     GLP      +       +++E KS K YL  
Sbjct: 35  RPIDVVIRQPEFT----------SLCPMTGLPDYGCITIRYRP-RHHIVELKSLKYYLLQ 83

Query: 100 FNQTRFNNWDEVRQTLERDLSTCAQG---KISVALYRLDELEGQPIGHFN 146
           +          V   +  DLS        ++S        +         
Sbjct: 84  YRNVGIFYEH-VINRILNDLSGAVAPVWMEVSGEFTARGGITTTVTAATG 132


>UniRef50_C1CXM3 Putative GTP cyclohydrolase I n=2 Tax=Deinococcus deserti VCD115
           RepID=C1CXM3_DEIDV
          Length = 155

 Score =  141 bits (356), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 30/152 (19%), Positives = 60/152 (39%), Gaps = 7/152 (4%)

Query: 129 VALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKS 188
           +      +          G  +D  D+ + +        + A    + ++  +++     
Sbjct: 1   MTTTPPCQPGFDRRYDVQG--LDAIDVAVLDTFAYVRQDDPAAYPGEPMDIEIITDEFSP 58

Query: 189 NCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQP 246
            C  +  PD+G L+I+Y+ R   ++ + L  YL S+R    +HE    R+  DL +   P
Sbjct: 59  VCPWSGLPDFGRLEIRYQPREKCVELKSLKYYLTSYRFVGIYHEHATRRLLADLTQLLDP 118

Query: 247 EKLSVYARYTRRGGLDINPWRSNSDFVPSTTR 278
             +++   Y  RGGL+         +V    R
Sbjct: 119 LSMTIRCDYGMRGGLNT---VCTVRYVAPERR 147



 Score = 72.7 bits (177), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 20/114 (17%), Positives = 32/114 (28%), Gaps = 19/114 (16%)

Query: 19  TDYRDTYDASLLQGV-------PRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLP 71
               D  D ++L          P +   +P+ ++     F                 GLP
Sbjct: 17  VQGLDAIDVAVLDTFAYVRQDDPAAYPGEPMDIEIITDEFSPV----------CPWSGLP 66

Query: 72  QVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQG 125
                 +         +E KS K YL S+      +    R  L  DL+     
Sbjct: 67  DFGRLEIRYQP-REKCVELKSLKYYLTSYRFVGIYHEHATR-RLLADLTQLLDP 118


>UniRef50_C0GIY6 7-cyano-7-deazaguanine reductase n=1 Tax=Dethiobacter alkaliphilus
           AHT 1 RepID=C0GIY6_9FIRM
          Length = 130

 Score =  141 bits (355), Expect = 3e-32,   Method: Composition-based stats.
 Identities = 33/123 (26%), Positives = 48/123 (39%), Gaps = 2/123 (1%)

Query: 152 DQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--Q 209
           + ++   N       LE       V    L S  + S C +T QPDW ++ I+Y      
Sbjct: 4   EFEVLGKNVPEPRRKLEVFEKPAGVDRVVLESDEVTSLCPVTGQPDWETVIIEYEPDRYC 63

Query: 210 IDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSN 269
           I+ + L  Y  SFR    F E    +I ND+   C+P    V      RGG+ I    + 
Sbjct: 64  IESKSLKLYFWSFRQEGVFCEGLAAQIANDVHAACKPFFCKVTVIQKPRGGITITASATA 123

Query: 270 SDF 272
              
Sbjct: 124 GGE 126



 Score = 88.5 bits (218), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 23/117 (19%), Positives = 35/117 (29%), Gaps = 7/117 (5%)

Query: 36  SLNRDPLGLKADNLPFHGTDIWTLYEL-SWLNAKGLPQVAVGHVELDYTSVNLIESKSFK 94
              R  L +  +        +    E+ S     G P      +E +      IESKS K
Sbjct: 13  PEPRRKLEV-FEKPAGVDRVVLESDEVTSLCPVTGQPDWETVIIEYEPDR-YCIESKSLK 70

Query: 95  LYLNSFNQTRFNNWDEVRQTLERDLSTCAQG---KISVALYRLDELEGQPIGHFNGT 148
           LY  SF Q          Q +  D+    +    K++V       +         G 
Sbjct: 71  LYFWSFRQEGVFCEGLAAQ-IANDVHAACKPFFCKVTVIQKPRGGITITASATAGGE 126


>UniRef50_B5IMF1 7-cyano-7-deazaguanine reductase n=1 Tax=Cyanobium sp. PCC 7001
           RepID=B5IMF1_9CHRO
          Length = 154

 Score =  141 bits (355), Expect = 3e-32,   Method: Composition-based stats.
 Identities = 25/109 (22%), Positives = 48/109 (44%), Gaps = 2/109 (1%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHN 226
                 +V E ++        C  +  PD+ +LQ+ Y+   R ++ + +  Y+ S+R   
Sbjct: 46  ENPRPGRVYEISITLPEFTCLCPFSGYPDFATLQLLYQPGPRVMELKAIKLYVNSYRDRT 105

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPS 275
             HE+ V R+ +D +  C P  + + A +  RG +      S+    PS
Sbjct: 106 ISHEEVVNRLLDDFVAACDPVWMQLEADFNPRGNVHTVIRASHGVRQPS 154



 Score = 80.4 bits (197), Expect = 6e-14,   Method: Composition-based stats.
 Identities = 18/100 (18%), Positives = 29/100 (29%), Gaps = 13/100 (13%)

Query: 26  DASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSV 85
           +ASLL             +      F                 G P  A   +       
Sbjct: 39  EASLLC-FENPRPGRVYEISITLPEFTC----------LCPFSGYPDFATLQLLYQP-GP 86

Query: 86  NLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQG 125
            ++E K+ KLY+NS+     ++ + V   L  D       
Sbjct: 87  RVMELKAIKLYVNSYRDRTISHEE-VVNRLLDDFVAACDP 125


>UniRef50_Q113I7 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2
           Tax=Cyanobacteria RepID=QUEF_TRIEI
          Length = 141

 Score =  140 bits (354), Expect = 4e-32,   Method: Composition-based stats.
 Identities = 20/109 (18%), Positives = 43/109 (39%), Gaps = 4/109 (3%)

Query: 167 LENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSF 222
           L         +  E  +        C  +  PD+ ++ I+Y    R ++ + +  Y+ S+
Sbjct: 31  LITFPNPRIGRRYEINISLPEFTCKCPFSGYPDFATIHIKYIPNERVVELKAIKLYINSY 90

Query: 223 RHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSD 271
           R     HE+ V +I +D +  C P ++ +   +  RG +       +  
Sbjct: 91  RERYISHEESVNQILDDFVAACDPLEVKIKGDFLPRGNVHTTIEVEHYK 139



 Score = 94.6 bits (234), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 20/125 (16%), Positives = 40/125 (32%), Gaps = 16/125 (12%)

Query: 6   NHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWL 65
               +  L  G+            L   P         +      F              
Sbjct: 12  QESNMQELKYGE-----RNILEGELITFPNPRIGRRYEINISLPEFTCK----------C 56

Query: 66  NAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQG 125
              G P  A  H++       ++E K+ KLY+NS+ +   ++ + V Q L+  ++ C   
Sbjct: 57  PFSGYPDFATIHIKYIPN-ERVVELKAIKLYINSYRERYISHEESVNQILDDFVAACDPL 115

Query: 126 KISVA 130
           ++ + 
Sbjct: 116 EVKIK 120


>UniRef50_Q8DNP8 NADPH-dependent 7-cyano-7-deazaguanine reductase n=26
           Tax=Streptococcus pneumoniae RepID=QUEF_STRR6
          Length = 154

 Score =  140 bits (352), Expect = 6e-32,   Method: Composition-based stats.
 Identities = 36/123 (29%), Positives = 62/123 (50%), Gaps = 5/123 (4%)

Query: 155 ITIDNYEFTTDY-LENATCGEKVVEETLVSHLLKSNCL--ITHQPDWGSLQIQYRGR--Q 209
           +    + +   + LE     E   E+ +  H+L  + L  IT QPD+ ++ I Y      
Sbjct: 7   VEAVTFAYGQHHHLEIQITREIAKEQGIRHHILDMSLLGQITAQPDFATIHISYIPDKLC 66

Query: 210 IDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSN 269
           ++ + L  YL S+R+H +FHE C+  I  DL+    P  L V+ ++T RGG+ I+P+ + 
Sbjct: 67  VESKSLKLYLFSYRNHGDFHENCINTIGKDLVNLLDPRYLEVWGKFTPRGGISIDPYYNY 126

Query: 270 SDF 272
              
Sbjct: 127 GKQ 129



 Score = 92.0 bits (227), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 18/90 (20%), Positives = 32/90 (35%), Gaps = 6/90 (6%)

Query: 58  TLYELSWLNA-KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLE 116
            + ++S L      P  A  H+         +ESKS KLYL S+      + + +  T+ 
Sbjct: 37  HILDMSLLGQITAQPDFATIHISYIPDK-LCVESKSLKLYLFSYRNHGDFHENCI-NTIG 94

Query: 117 RDLSTCAQG---KISVALYRLDELEGQPIG 143
           +DL         ++         +   P  
Sbjct: 95  KDLVNLLDPRYLEVWGKFTPRGGISIDPYY 124


>UniRef50_B0CDX9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=40
           Tax=Cyanobacteria RepID=QUEF_ACAM1
          Length = 144

 Score =  140 bits (352), Expect = 6e-32,   Method: Composition-based stats.
 Identities = 20/109 (18%), Positives = 44/109 (40%), Gaps = 4/109 (3%)

Query: 167 LENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSF 222
           L         +  +  +        C  +  PD+ ++ + Y   Q  ++ + L  Y+ S+
Sbjct: 36  LITFPNPRVGRRYDIHITLPEFTCKCPFSGYPDFATIHLTYVPDQRVVELKALKLYINSY 95

Query: 223 RHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSD 271
           R     HE+ V +I +D++  C P +++V   +  RG +       +  
Sbjct: 96  RDRYISHEESVNQILDDIVAACDPLEITVKGDFLPRGNVHTVIEVHHQK 144



 Score =  108 bits (269), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 22/128 (17%), Positives = 41/128 (32%), Gaps = 16/128 (12%)

Query: 3   SYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYEL 62
           +  + Q  +    G+            L   P         +      F           
Sbjct: 14  NAQSVQETSESKYGE-----RQIAEGTLITFPNPRVGRRYDIHITLPEFTCK-------- 60

Query: 63  SWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTC 122
                 G P  A  H+        ++E K+ KLY+NS+     ++ + V Q L+  ++ C
Sbjct: 61  --CPFSGYPDFATIHLTYVPD-QRVVELKALKLYINSYRDRYISHEESVNQILDDIVAAC 117

Query: 123 AQGKISVA 130
              +I+V 
Sbjct: 118 DPLEITVK 125


>UniRef50_B4U9Q5 7-cyano-7-deazaguanine reductase n=5 Tax=Bacteria
           RepID=B4U9Q5_HYDS0
          Length = 128

 Score =  140 bits (352), Expect = 7e-32,   Method: Composition-based stats.
 Identities = 28/126 (22%), Positives = 47/126 (37%), Gaps = 5/126 (3%)

Query: 153 QDITIDNYEFTTDYLENATCGEK--VVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR-- 208
           Q+      E     LE      K       +        C  +  PD+ +++I+Y     
Sbjct: 3   QEKKYGEIEIEKAALEPWENPAKENDYIIEMSFPEFSCLCPRSGYPDYATIKIRYIPNEY 62

Query: 209 QIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINP-WR 267
            ++ + L  +L SFR+    HE     I+N L    +P+ L V   +  RG L      R
Sbjct: 63  IVELKSLKLWLNSFRNQYISHEAATNTIYNKLFELLKPKFLEVIGDFHPRGNLHTVVRVR 122

Query: 268 SNSDFV 273
           S+  + 
Sbjct: 123 SDKKYD 128



 Score = 92.3 bits (228), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 21/124 (16%), Positives = 35/124 (28%), Gaps = 21/124 (16%)

Query: 24  TYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYT 83
             + + L+        +   ++     F                 G P  A   +     
Sbjct: 11  EIEKAALEPWENPAKENDYIIEMSFPEFSC----------LCPRSGYPDYATIKIRYIPN 60

Query: 84  SVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRLDELEGQPIG 143
              ++E KS KL+LNSF     ++      T+   L           L +   LE     
Sbjct: 61  -EYIVELKSLKLWLNSFRNQYISHE-AATNTIYNKL---------FELLKPKFLEVIGDF 109

Query: 144 HFNG 147
           H  G
Sbjct: 110 HPRG 113


>UniRef50_Q2J7K4 NADPH-dependent 7-cyano-7-deazaguanine reductase n=4
           Tax=Actinomycetales RepID=QUEF_FRASC
          Length = 125

 Score =  138 bits (349), Expect = 2e-31,   Method: Composition-based stats.
 Identities = 31/99 (31%), Positives = 47/99 (47%), Gaps = 2/99 (2%)

Query: 167 LENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRH 224
           LE     +   E  +        C IT QPDW +++I YR   R ++ + L  YL +FR 
Sbjct: 17  LETFPIDDTSQEIRIDCREFTCRCPITGQPDWATIRIDYRPGGRGLETKSLKLYLETFRE 76

Query: 225 HNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDI 263
              FHE     I +DL+    P +L+V   +  RGG+ +
Sbjct: 77  EGIFHEHLATLIRDDLVAALAPVQLTVTVNFNARGGIAL 115



 Score = 77.3 bits (189), Expect = 5e-13,   Method: Composition-based stats.
 Identities = 21/135 (15%), Positives = 38/135 (28%), Gaps = 18/135 (13%)

Query: 10  LAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKG 69
           +A   LG      +      L+  P  ++     ++ D   F                 G
Sbjct: 1   MALTKLGN----PEAKADRSLETFP--IDDTSQEIRIDCREFTCR----------CPITG 44

Query: 70  LPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISV 129
            P  A   ++        +E+KS KLYL +F +    +       +  DL          
Sbjct: 45  QPDWATIRIDYRP-GGRGLETKSLKLYLETFREEGIFHEHLAT-LIRDDLVAALAPVQLT 102

Query: 130 ALYRLDELEGQPIGH 144
                +   G  +  
Sbjct: 103 VTVNFNARGGIALAA 117


>UniRef50_B2KDU6 NADPH-dependent 7-cyano-7-deazaguanine reductase n=4 Tax=Bacteria
           RepID=QUEF_ELUMP
          Length = 132

 Score =  137 bits (346), Expect = 3e-31,   Method: Composition-based stats.
 Identities = 25/99 (25%), Positives = 43/99 (43%), Gaps = 2/99 (2%)

Query: 175 KVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRHHNEFHEQC 232
           +  +  +      S C  T  PD+G + I Y      ++ + L  YL+ +R    F E  
Sbjct: 33  RDYDIRIELPEFTSVCPKTGLPDFGVITIDYIPDRLCLELKSLKYYLLEYRDMGIFMENI 92

Query: 233 VERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSD 271
             +I +D+++ C+P+K  V   +T RGGL          
Sbjct: 93  ANKILDDVVKACKPKKAVVTGDFTPRGGLRSVIVAKYEK 131



 Score = 85.0 bits (209), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 15/107 (14%), Positives = 30/107 (28%), Gaps = 15/107 (14%)

Query: 40  DPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNS 99
               ++ +   F           S     GLP   V  ++        +E KS K YL  
Sbjct: 33  RDYDIRIELPEFT----------SVCPKTGLPDFGVITIDYIPDR-LCLELKSLKYYLLE 81

Query: 100 FNQTRFNNWDEVRQTLERDLSTCAQGK---ISVALYRLDELEGQPIG 143
           +        + +   +  D+    + K   ++        L    + 
Sbjct: 82  YRDMGIFMEN-IANKILDDVVKACKPKKAVVTGDFTPRGGLRSVIVA 127


>UniRef50_A6Q0W4 NADPH-dependent 7-cyano-7-deazaguanine reductase n=6 Tax=Bacteria
           RepID=QUEF_NITSB
          Length = 131

 Score =  137 bits (346), Expect = 4e-31,   Method: Composition-based stats.
 Identities = 22/112 (19%), Positives = 45/112 (40%), Gaps = 2/112 (1%)

Query: 154 DITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--ID 211
           +  I  ++   D         K  +  +        C  +  PD+ ++ ++Y   Q  ++
Sbjct: 5   EKEIQEFDPKKDLEIWPNKHNKPYKIKITLPEFSCLCPRSGYPDYATMHLEYIPDQYVVE 64

Query: 212 REKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDI 263
            + L  Y+ SFR+    HE     IF+ L    +P+ + + A +  RG +  
Sbjct: 65  LKALKLYINSFRNRYISHEDSTNEIFDTLYSKLKPKYMRLVADFNPRGNVHT 116



 Score = 80.4 bits (197), Expect = 6e-14,   Method: Composition-based stats.
 Identities = 25/130 (19%), Positives = 42/130 (32%), Gaps = 17/130 (13%)

Query: 30  LQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIE 89
           L+  P   N  P  +K     F                 G P  A  H+E       ++E
Sbjct: 17  LEIWPNKHN-KPYKIKITLPEFSC----------LCPRSGYPDYATMHLEYIPD-QYVVE 64

Query: 90  SKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRLDELEGQPIGHFNGTC 149
            K+ KLY+NSF     ++ D     +   L +  + K    +   +              
Sbjct: 65  LKALKLYINSFRNRYISHEDS-TNEIFDTLYSKLKPKYMRLVADFNPRGNVHTL----IE 119

Query: 150 IDDQDITIDN 159
           ID ++I   +
Sbjct: 120 IDSEEIEKVS 129


>UniRef50_B7JWF0 7-cyano-7-deazaguanine reductase n=8 Tax=Cyanobacteria
           RepID=B7JWF0_CYAP8
          Length = 142

 Score =  135 bits (340), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 17/107 (15%), Positives = 41/107 (38%), Gaps = 4/107 (3%)

Query: 167 LENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSF 222
           L         +  +  +        C  +  PD+ +L + Y      ++ + L  Y+  +
Sbjct: 31  LITFPNPRIGRRYDINITLPEFTCKCPFSGYPDFATLYLTYIPDEKVVELKALKLYINRY 90

Query: 223 RHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSN 269
           R     HE+ + +I +D +  C P ++++   +  RG +       +
Sbjct: 91  RDRYISHEESINQILDDFVAACDPLEVTLKGDFNPRGNVHTVIEVRH 137



 Score = 93.9 bits (232), Expect = 6e-18,   Method: Composition-based stats.
 Identities = 15/105 (14%), Positives = 35/105 (33%), Gaps = 11/105 (10%)

Query: 26  DASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSV 85
           +   L   P         +      F                 G P  A  ++       
Sbjct: 27  EEGELITFPNPRIGRRYDINITLPEFTCK----------CPFSGYPDFATLYLTYIPD-E 75

Query: 86  NLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVA 130
            ++E K+ KLY+N +     ++ + + Q L+  ++ C   ++++ 
Sbjct: 76  KVVELKALKLYINRYRDRYISHEESINQILDDFVAACDPLEVTLK 120


>UniRef50_D2REX4 GTP cyclohydrolase I n=1 Tax=Archaeoglobus profundus DSM 5631
           RepID=D2REX4_ARCPR
          Length = 236

 Score =  134 bits (338), Expect = 3e-30,   Method: Composition-based stats.
 Identities = 35/182 (19%), Positives = 63/182 (34%), Gaps = 26/182 (14%)

Query: 106 NNWDEVRQTLERDLSTCAQGKISVALY---RLDELEGQPIGHFNGTCIDDQDITIDNYEF 162
           +N +  R+ + RDL  C +  + V +        +    I    G  +           +
Sbjct: 47  DNEELCREIVTRDLELCEKADVIVLVAKHPSFGAMAEVVISAMKGKPVVAFCPEKVRSPW 106

Query: 163 TTDY--------------LENATCGEKVVEETLVSHL-------LKSNCLITHQPDWGSL 201
              +              L+      + +      H            C +T   D G++
Sbjct: 107 PIYFANKVVRSEEELVRALKELETPLRTIPNVYSDHEAEFTYTKFTCICPVTGLRDIGTI 166

Query: 202 QIQYRG--RQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRG 259
           +I+Y+   R ++ E L  Y   F      HE  V ++FND+ +   PE L V A +  R 
Sbjct: 167 KIRYKPKDRILEYESLDSYFKLFADKKMHHEAVVCKVFNDIYQALNPEWLEVVAEFEERS 226

Query: 260 GL 261
           G+
Sbjct: 227 GV 228



 Score = 47.7 bits (112), Expect = 5e-04,   Method: Composition-based stats.
 Identities = 13/111 (11%), Positives = 30/111 (27%), Gaps = 14/111 (12%)

Query: 30  LQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIE 89
           L+ +P   +      +     F                 GL  +    +        ++E
Sbjct: 132 LRTIPNVYSDHE--AEFTYTKFTCI----------CPVTGLRDIGTIKIRYKP-KDRILE 178

Query: 90  SKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRLDELEGQ 140
            +S   Y   F   +  + + V   +  D+      +    +   +E  G 
Sbjct: 179 YESLDSYFKLFADKKM-HHEAVVCKVFNDIYQALNPEWLEVVAEFEERSGV 228


>UniRef50_Q5HS73 NADPH-dependent 7-cyano-7-deazaguanine reductase n=20 Tax=Bacteria
           RepID=QUEF_CAMJR
          Length = 127

 Score =  132 bits (332), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 22/117 (18%), Positives = 47/117 (40%), Gaps = 4/117 (3%)

Query: 161 EFTTDYLENATCGEK-VVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLR 217
           EF  + +E      K      +        C  +  PD+ ++ ++Y   +  ++ + +  
Sbjct: 10  EFDVENMEIWPNDAKNDYIIKITLPEFMCCCPRSGYPDFATIYLEYMPNKFVVELKAIKL 69

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINP-WRSNSDFV 273
           Y+ +F + N  HE  +  I+N L    +P+ + V   +  RG +      RS+    
Sbjct: 70  YINTFMYRNVSHEASINEIYNTLKDKLKPKWIKVVGDFNPRGNVHTVIECRSDMVVP 126



 Score = 68.8 bits (167), Expect = 2e-10,   Method: Composition-based stats.
 Identities = 18/116 (15%), Positives = 38/116 (32%), Gaps = 13/116 (11%)

Query: 23  DTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDY 82
             +D   ++  P    ++   +K     F          +      G P  A  ++E   
Sbjct: 9   KEFDVENMEIWPN-DAKNDYIIKITLPEF----------MCCCPRSGYPDFATIYLEYMP 57

Query: 83  TSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRLDELE 138
               ++E K+ KLY+N+F   R  + +     +   L    + K    +   +   
Sbjct: 58  NK-FVVELKAIKLYINTF-MYRNVSHEASINEIYNTLKDKLKPKWIKVVGDFNPRG 111


>UniRef50_B0KAC5 NADPH-dependent 7-cyano-7-deazaguanine reductase n=11
           Tax=Clostridia RepID=QUEF_THEP3
          Length = 133

 Score =  131 bits (329), Expect = 3e-29,   Method: Composition-based stats.
 Identities = 29/125 (23%), Positives = 50/125 (40%), Gaps = 12/125 (9%)

Query: 150 IDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ 209
           ID + +    YE+           EK      +++   S C  T  PD   L I+Y   +
Sbjct: 18  IDKEVLESIEYEY----------PEKNTIVEYITNEFSSVCPWTGLPDNAKLTIRYIPSK 67

Query: 210 --IDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWR 267
             ++ + L  YL S+R+     E  + RI +DL+   QP+ + +   +  RGG+      
Sbjct: 68  KLVELKSLKYYLTSYRNVGILQEHAINRILDDLVELLQPKFMEIIGEFQERGGIATRIVA 127

Query: 268 SNSDF 272
                
Sbjct: 128 KYEKE 132



 Score = 81.9 bits (201), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 24/125 (19%), Positives = 36/125 (28%), Gaps = 12/125 (9%)

Query: 19  TDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHV 78
           T   +  D  +L+ +          ++     F           S     GLP  A   +
Sbjct: 12  TYGYEKIDKEVLESIEYEYPEKNTIVEYITNEFS----------SVCPWTGLPDNAKLTI 61

Query: 79  ELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRLDELE 138
                S  L+E KS K YL S+          +   +  DL    Q K    +    E  
Sbjct: 62  RYIP-SKKLVELKSLKYYLTSYRNVGILQEHAI-NRILDDLVELLQPKFMEIIGEFQERG 119

Query: 139 GQPIG 143
           G    
Sbjct: 120 GIATR 124


>UniRef50_A5IIZ4 NADPH-dependent 7-cyano-7-deazaguanine reductase n=7
           Tax=Thermotogaceae RepID=QUEF_THEP1
          Length = 137

 Score =  127 bits (319), Expect = 4e-28,   Method: Composition-based stats.
 Identities = 27/104 (25%), Positives = 47/104 (45%), Gaps = 3/104 (2%)

Query: 164 TDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR---QIDREKLLRYLV 220
           TD+LE      K     + +    + C  +  PD G + I+Y       ++ + L  Y V
Sbjct: 19  TDFLEAIDFDGKDEYIKIETDEFSAVCPFSGLPDIGRVIIEYYPDGGKIVELKSLKYYFV 78

Query: 221 SFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDIN 264
           SFR+   + E+  +RI+ DL    + +++ V   Y  RGG+   
Sbjct: 79  SFRNVGIYQEEATKRIYEDLKNLLKTDRIRVTVIYNIRGGIKTT 122



 Score = 70.0 bits (170), Expect = 9e-11,   Method: Composition-based stats.
 Identities = 18/122 (14%), Positives = 33/122 (27%), Gaps = 13/122 (10%)

Query: 28  SLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNL 87
             L+ +    +     +K +   F                 GLP +    +E       +
Sbjct: 20  DFLEAID--FDGKDEYIKIETDEFSAV----------CPFSGLPDIGRVIIEYYPDGGKI 67

Query: 88  IESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRLDELEGQPIGHFNG 147
           +E KS K Y  SF        +   + +  DL    +          +   G       G
Sbjct: 68  VELKSLKYYFVSFRNVGIYQEEA-TKRIYEDLKNLLKTDRIRVTVIYNIRGGIKTTTQMG 126

Query: 148 TC 149
           + 
Sbjct: 127 SL 128


>UniRef50_B5JRC9 7-cyano-7-deazaguanine reductase n=1 Tax=Verrucomicrobiae bacterium
           DG1235 RepID=B5JRC9_9BACT
          Length = 126

 Score =  127 bits (318), Expect = 6e-28,   Method: Composition-based stats.
 Identities = 30/108 (27%), Positives = 49/108 (45%), Gaps = 2/108 (1%)

Query: 163 TTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLV 220
             D L+     E V   T+ S  L S+C IT QPD+ ++ I+Y  +   I+ + L  +L 
Sbjct: 13  PIDELDTFEAPEGVTTVTMTSDELTSSCPITGQPDFYNVSIEYAPKELCIESKSLKLFLW 72

Query: 221 SFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRS 268
            FR    F E+    I + +++   P +  V      RGG++I     
Sbjct: 73  GFRDKAMFAEKIAAVICDRVVQDISPRRCRVMTFQKARGGIEIESVAE 120



 Score = 69.6 bits (169), Expect = 1e-10,   Method: Composition-based stats.
 Identities = 19/99 (19%), Positives = 30/99 (30%), Gaps = 3/99 (3%)

Query: 45  KADNLPFHGTDIWTLYEL-SWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQT 103
             +      T   T  EL S     G P      +E        IESKS KL+L  F   
Sbjct: 19  TFEAPEGVTTVTMTSDELTSSCPITGQPDFYNVSIEYAP-KELCIESKSLKLFLWGFRD- 76

Query: 104 RFNNWDEVRQTLERDLSTCAQGKISVALYRLDELEGQPI 142
           +    +++   +   +      +    +       G  I
Sbjct: 77  KAMFAEKIAAVICDRVVQDISPRRCRVMTFQKARGGIEI 115


>UniRef50_A8W229 ATP-dependent metalloprotease FtsH n=1 Tax=Bacillus
           selenitireducens MLS10 RepID=A8W229_9BACI
          Length = 135

 Score =  126 bits (316), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 27/117 (23%), Positives = 49/117 (41%), Gaps = 3/117 (2%)

Query: 159 NYEFTTDYLENATCGEKVV-EETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKL 215
           + E   + L +       V      +    + C  T QPD+G ++I+Y  R   I+ + L
Sbjct: 18  SVEEGRNVLRDEAFPAPDVSVVRFKALEFTAVCPKTGQPDFGQVEIEYVPRNKCIESKSL 77

Query: 216 LRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDF 272
             YL S+R    + E    +I +D++   +P ++ V    T RGG+ +         
Sbjct: 78  KFYLWSYRDEGAYCESLAAQIADDVMAAIEPARVKVMVHQTPRGGIQLETEAERIHE 134



 Score = 98.9 bits (245), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 21/106 (19%), Positives = 36/106 (33%), Gaps = 6/106 (5%)

Query: 32  GVPRS----LNRDPLGLKADNLPFHGTDIWTLYELSW-LNAKGLPQVAVGHVELDYTSVN 86
            +PR       R+ L  +A   P      +   E +      G P      +E    +  
Sbjct: 12  PMPRPASVEEGRNVLRDEAFPAPDVSVVRFKALEFTAVCPKTGQPDFGQVEIEYVPRN-K 70

Query: 87  LIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALY 132
            IESKS K YL S+            Q  +  ++     ++ V ++
Sbjct: 71  CIESKSLKFYLWSYRDEGAYCESLAAQIADDVMAAIEPARVKVMVH 116


>UniRef50_B5IBP5 7-cyano-7-deazaguanine reductase n=2 Tax=Aciduliprofundum boonei
           T469 RepID=B5IBP5_9EURY
          Length = 135

 Score =  120 bits (302), Expect = 5e-26,   Method: Composition-based stats.
 Identities = 25/109 (22%), Positives = 42/109 (38%), Gaps = 2/109 (1%)

Query: 161 EFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRY 218
           EF           E       +   L + C  T  PD+  L+I Y   +   + + L  Y
Sbjct: 2   EFPKIETAQYEYPETKEVVEYIYPELTAVCPQTGLPDYYILRILYEPDKKLPELKSLKMY 61

Query: 219 LVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWR 267
           L+++R+   +HE    +I +D     +P  + V      RGG+     R
Sbjct: 62  LIAYRNFGIWHEHLANKILDDFKSAVEPRWVYVELYVNNRGGIYTTVRR 110



 Score = 60.4 bits (145), Expect = 6e-08,   Method: Composition-based stats.
 Identities = 15/68 (22%), Positives = 25/68 (36%), Gaps = 1/68 (1%)

Query: 65  LNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQ 124
               GLP   +  +  +     L E KS K+YL ++      +     + L+   S    
Sbjct: 31  CPQTGLPDYYILRILYEPDK-KLPELKSLKMYLIAYRNFGIWHEHLANKILDDFKSAVEP 89

Query: 125 GKISVALY 132
             + V LY
Sbjct: 90  RWVYVELY 97


>UniRef50_D0MDN3 7-cyano-7-deazaguanine reductase n=1 Tax=Rhodothermus marinus DSM
           4252 RepID=D0MDN3_RHOM4
          Length = 168

 Score =  105 bits (261), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 25/83 (30%), Positives = 39/83 (46%), Gaps = 3/83 (3%)

Query: 185 LLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLR 242
              + C  +  PD+G L+I+Y      ++ + L  Y+VS+R+     E     I+ DL+R
Sbjct: 76  EFSAVCPFSGLPDYGVLRIEYVPGSWILELKSLKYYIVSWRNIGAAQEDLTAIIYQDLMR 135

Query: 243 FC-QPEKLSVYARYTRRGGLDIN 264
               PE L V   Y  RGG+   
Sbjct: 136 HLEDPEYLRVITVYNVRGGIRTT 158



 Score = 62.3 bits (150), Expect = 2e-08,   Method: Composition-based stats.
 Identities = 16/83 (19%), Positives = 26/83 (31%), Gaps = 2/83 (2%)

Query: 61  ELSW-LNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDL 119
           E S      GLP   V  +E    S  ++E KS K Y+ S+        D      +  +
Sbjct: 76  EFSAVCPFSGLPDYGVLRIEYVPGS-WILELKSLKYYIVSWRNIGAAQEDLTAIIYQDLM 134

Query: 120 STCAQGKISVALYRLDELEGQPI 142
                 +    +   +   G   
Sbjct: 135 RHLEDPEYLRVITVYNVRGGIRT 157


>UniRef50_A2BLN0 Predicted GTP cyclohydrolase I n=1 Tax=Hyperthermus butylicus DSM
           5456 RepID=A2BLN0_HYPBU
          Length = 119

 Score = 80.0 bits (196), Expect = 9e-14,   Method: Composition-based stats.
 Identities = 17/93 (18%), Positives = 35/93 (37%), Gaps = 7/93 (7%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG-------RQIDREKLLRYLVS 221
               GE  VE+ +++  +++ C +T   D   + ++Y+        R I+      YL S
Sbjct: 7   RVVEGEACVEKVVLTGSVEAVCPVTGMVDLYRVIVEYKPSSAGRVCRYIEALSFHFYLQS 66

Query: 222 FRHHNEFHEQCVERIFNDLLRFCQPEKLSVYAR 254
           ++      E+    I  D        ++ V   
Sbjct: 67  YKGRKILQEELTATIVRDFCEALGGGEVKVVTE 99


>UniRef50_Q9YBX9 Putative GTP cyclohydrolase I n=1 Tax=Aeropyrum pernix
           RepID=Q9YBX9_AERPE
          Length = 101

 Score = 78.5 bits (192), Expect = 3e-13,   Method: Composition-based stats.
 Identities = 19/67 (28%), Positives = 28/67 (41%), Gaps = 2/67 (2%)

Query: 188 SNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQ 245
           + C  T  PD   ++I+Y  R   ++   L  +L SFR      EQ    I   L    +
Sbjct: 8   AVCPFTGAPDSYDVEIEYVSRDACLEALSLASWLESFRGVKISQEQLAHEIALTLKELLK 67

Query: 246 PEKLSVY 252
           PE + V 
Sbjct: 68  PEYVCVK 74


>UniRef50_B1YDZ8 GTP cyclohydrolase I n=5 Tax=Thermoproteaceae RepID=B1YDZ8_THENV
          Length = 114

 Score = 74.6 bits (182), Expect = 4e-12,   Method: Composition-based stats.
 Identities = 16/91 (17%), Positives = 34/91 (37%), Gaps = 7/91 (7%)

Query: 188 SNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQ 245
           + C I+   D   + ++Y  R   +  E+  R + S+R     HE+    +   +     
Sbjct: 24  AVCPISKVVDSFEVTVEYMPRGGALAIEEFKRMVDSYRGREILHEELAVDLMEKIKAAVN 83

Query: 246 PEKLSV--YARYTRRGGLDINPWRSNSDFVP 274
           P  + V   + Y    G+++     +    P
Sbjct: 84  PPYVKVVLKSVYI---GVEVEVVAESGGVPP 111


>UniRef50_B1SCE4 Putative uncharacterized protein n=1 Tax=Streptococcus infantarius
           subsp. infantarius ATCC BAA-102 RepID=B1SCE4_9STRE
          Length = 58

 Score = 43.0 bits (100), Expect = 0.011,   Method: Composition-based stats.
 Identities = 11/32 (34%), Positives = 19/32 (59%)

Query: 240 LLRFCQPEKLSVYARYTRRGGLDINPWRSNSD 271
           ++   QP  L V+ ++T RGGL I+P+ +   
Sbjct: 1   MIDLLQPRYLEVWGKFTPRGGLSIDPYFNYGK 32


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.310    0.143    0.419 

Lambda     K      H
   0.267   0.0441    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,154,019,592
Number of Sequences: 3077464
Number of extensions: 50930777
Number of successful extensions: 114706
Number of sequences better than 1.0e-01: 73
Number of HSP's better than  0.1 without gapping: 145
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 114082
Number of HSP's gapped (non-prelim): 253
length of query: 282
length of database: 1,040,396,356
effective HSP length: 127
effective length of query: 155
effective length of database: 649,558,428
effective search space: 100681556340
effective search space used: 100681556340
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.1 bits)
S2: 92 (39.9 bits)
