BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (282 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_Q0T1R0 NADPH-dependent 7-cyano-7-deazaguanine reductase...   583   e-165
UniRef50_Q0HGT5 NADPH-dependent 7-cyano-7-deazaguanine reductase...   370   e-101
UniRef50_Q1LSV9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   308   2e-82
UniRef50_Q1K442 GTP cyclohydrolase I n=2 Tax=Proteobacteria RepI...   298   2e-79
UniRef50_Q7WH69 NADPH-dependent 7-cyano-7-deazaguanine reductase...   283   4e-75
UniRef50_A4VK37 GTP cyclohydrolase I, putative n=2 Tax=Gammaprot...   282   7e-75
UniRef50_Q5P6G9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   277   2e-73
UniRef50_Q5X7D5 NADPH-dependent 7-cyano-7-deazaguanine reductase...   273   5e-72
UniRef50_A4T050 GTP cyclohydrolase I n=2 Tax=Proteobacteria RepI...   268   1e-70
UniRef50_Q21VW6 NADPH-dependent 7-cyano-7-deazaguanine reductase...   259   5e-68
UniRef50_Q6ARX8 NADPH-dependent 7-cyano-7-deazaguanine reductase...   257   2e-67
UniRef50_Q0VR70 NADPH-dependent 7-cyano-7-deazaguanine reductase...   253   4e-66
UniRef50_P44165 Uncharacterized protein HI1340 n=9 Tax=Gammaprot...   235   1e-60
UniRef50_A8F0H9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   231   3e-59
UniRef50_C8PYF2 Queuine synthase n=3 Tax=Moraxellaceae RepID=C8P...   225   1e-57
UniRef50_Q6FA61 NADPH-dependent 7-cyano-7-deazaguanine reductase...   214   3e-54
UniRef50_A4A3I6 GTP cyclohydrolase I n=1 Tax=Congregibacter lito...   213   5e-54
UniRef50_Q1QDK8 NADPH-dependent 7-cyano-7-deazaguanine reductase...   207   3e-52
UniRef50_B8KG68 NADPH-dependent 7-cyano-7-deazaguanine reductase...   201   3e-50
UniRef50_B8KRQ4 NADPH-dependent 7-cyano-7-deazaguanine reductase...   180   4e-44
UniRef50_A0Z1W1 Putative uncharacterized protein n=1 Tax=marine ...   179   8e-44
UniRef50_B7RUV0 GTP cyclohydrolase I subfamily, putative n=1 Tax...   153   5e-36
UniRef50_Q6WI29 GTP cyclohydrolase I family protein n=1 Tax=Vibr...   144   2e-33
UniRef50_Q9ZJJ9 NADPH-dependent 7-cyano-7-deazaguanine reductase...    74   6e-12
UniRef50_A9VKS1 NADPH-dependent 7-cyano-7-deazaguanine reductase...    73   1e-11
UniRef50_Q6MRJ2 NADPH-dependent 7-cyano-7-deazaguanine reductase...    72   2e-11
UniRef50_Q8DNP8 NADPH-dependent 7-cyano-7-deazaguanine reductase...    68   3e-10
UniRef50_C7M0Q2 7-cyano-7-deazaguanine reductase n=1 Tax=Acidimi...    68   3e-10
UniRef50_B3E3W5 7-cyano-7-deazaguanine reductase n=3 Tax=Proteob...    67   5e-10
UniRef50_D1N404 7-cyano-7-deazaguanine reductase n=3 Tax=Bacteri...    63   1e-08
UniRef50_D2L9R9 7-cyano-7-deazaguanine reductase n=1 Tax=Desulfo...    62   2e-08
UniRef50_C4XPJ6 Putative uncharacterized protein n=1 Tax=Desulfo...    60   6e-08
UniRef50_Q2J7K4 NADPH-dependent 7-cyano-7-deazaguanine reductase...    60   6e-08
UniRef50_B2UN89 7-cyano-7-deazaguanine reductase n=2 Tax=Verruco...    58   3e-07
UniRef50_C7JB01 Queuosine biosynthesis protein QueF n=9 Tax=Alph...    55   3e-06
UniRef50_A8ZUH0 GTP cyclohydrolase I n=2 Tax=Desulfobacteraceae ...    54   5e-06
UniRef50_Q8UD54 NADPH-dependent 7-cyano-7-deazaguanine reductase...    54   7e-06
UniRef50_A6C8E2 Putative uncharacterized protein n=2 Tax=Plancto...    52   2e-05
UniRef50_Q0AAV5 NADPH-dependent 7-cyano-7-deazaguanine reductase...    50   9e-05
UniRef50_B3QM19 NADPH-dependent 7-cyano-7-deazaguanine reductase...    50   1e-04
UniRef50_Q3SJI1 NADPH-dependent 7-cyano-7-deazaguanine reductase...    49   2e-04
UniRef50_C1CXM3 Putative GTP cyclohydrolase I n=2 Tax=Deinococcu...    49   2e-04
UniRef50_Q04RM8 NADPH-dependent 7-cyano-7-deazaguanine reductase...    49   2e-04
UniRef50_Q2IH01 NADPH-dependent 7-cyano-7-deazaguanine reductase...    49   2e-04
UniRef50_A8W229 ATP-dependent metalloprotease FtsH n=1 Tax=Bacil...    49   3e-04
UniRef50_B5JRC9 7-cyano-7-deazaguanine reductase n=1 Tax=Verruco...    48   3e-04
UniRef50_B2KDU6 NADPH-dependent 7-cyano-7-deazaguanine reductase...    48   3e-04
UniRef50_Q8GJN6 NADPH-dependent 7-cyano-7-deazaguanine reductase...    48   3e-04
UniRef50_C0GIY6 7-cyano-7-deazaguanine reductase n=1 Tax=Dethiob...    47   5e-04
UniRef50_B7J648 NADPH-dependent 7-cyano-7-deazaguanine reductase...    47   0.001
UniRef50_A5IIZ4 NADPH-dependent 7-cyano-7-deazaguanine reductase...    46   0.001
UniRef50_B3EMR0 NADPH-dependent 7-cyano-7-deazaguanine reductase...    46   0.002
UniRef50_Q2LTJ0 NADPH-dependent 7-cyano-7-deazaguanine reductase...    46   0.002
UniRef50_A1WY83 NADPH-dependent 7-cyano-7-deazaguanine reductase...    45   0.003
UniRef50_B0KAC5 NADPH-dependent 7-cyano-7-deazaguanine reductase...    45   0.004
UniRef50_B8IYG6 NADPH-dependent 7-cyano-7-deazaguanine reductase...    43   0.012
UniRef50_D2REX4 GTP cyclohydrolase I n=1 Tax=Archaeoglobus profu...    42   0.017
UniRef50_B8HRW7 7-cyano-7-deazaguanine reductase n=2 Tax=Cyanoba...    41   0.049

>UniRef50_Q0T1R0 NADPH-dependent 7-cyano-7-deazaguanine reductase n=139
           Tax=Gammaproteobacteria RepID=QUEF_SHIF8
          Length = 282

 Score =  583 bits (1504), Expect = e-165,   Method: Compositional matrix adjust.
 Identities = 280/282 (99%), Positives = 281/282 (99%)

Query: 1   MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLY 60
           MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLY
Sbjct: 1   MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLY 60

Query: 61  ELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLS 120
           ELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLS
Sbjct: 61  ELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLS 120

Query: 121 TCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEET 180
           TCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENAT GEKVVEET
Sbjct: 121 TCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATSGEKVVEET 180

Query: 181 LVSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDL 240
           LVSHLLKSNCLITHQPDWGS+QIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDL
Sbjct: 181 LVSHLLKSNCLITHQPDWGSIQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDL 240

Query: 241 LRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           LRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ
Sbjct: 241 LRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282


>UniRef50_Q0HGT5 NADPH-dependent 7-cyano-7-deazaguanine reductase n=142
           Tax=Proteobacteria RepID=QUEF_SHESM
          Length = 286

 Score =  370 bits (950), Expect = e-101,   Method: Compositional matrix adjust.
 Identities = 177/279 (63%), Positives = 219/279 (78%)

Query: 4   YANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELS 63
           Y++ + LAGLTLGK+TDY+  YDASLLQGVPRSLNR+ + L A++LPFHG DIWT YELS
Sbjct: 8   YSDAKELAGLTLGKATDYQAEYDASLLQGVPRSLNRNAINLTAESLPFHGADIWTAYELS 67

Query: 64  WLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCA 123
           WLNAKG P VA+  ++L + S NLIESKSFKLYLNSFNQT+F+N D V++TL +DLS CA
Sbjct: 68  WLNAKGKPMVAIADIQLSHESQNLIESKSFKLYLNSFNQTKFDNIDAVQKTLVQDLSECA 127

Query: 124 QGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVS 183
           QG+++V +        Q +    GTCIDD DI + +Y+F  DYLEN+T  +++V ETL S
Sbjct: 128 QGQVTVKIIEPKSFGIQRVVELPGTCIDDLDIEVSDYDFNPDYLENSTDDKQIVAETLNS 187

Query: 184 HLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRF 243
           +LLKSNCLIT QPDWGS+ I+Y+G +IDREKLLRYL+SFR HNEFHEQCVERIF DL  +
Sbjct: 188 NLLKSNCLITSQPDWGSVMIRYQGPKIDREKLLRYLISFRQHNEFHEQCVERIFVDLKHY 247

Query: 244 CQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           C   KL+VYARYTRRGGLDINP+RS+ +    + RL RQ
Sbjct: 248 CHCTKLTVYARYTRRGGLDINPYRSDFEHPGESHRLARQ 286


>UniRef50_Q1LSV9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2
           Tax=Gammaproteobacteria RepID=QUEF_BAUCH
          Length = 283

 Score =  308 bits (788), Expect = 2e-82,   Method: Compositional matrix adjust.
 Identities = 153/279 (54%), Positives = 195/279 (69%), Gaps = 4/279 (1%)

Query: 7   HQALAGLTLGKS-TDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWL 65
           +Q L    L KS   YR  Y+  LLQ +PR+++R+ LG+ + +LPF G D WTLYELSWL
Sbjct: 6   YQLLQKFKLDKSKISYRTHYNPMLLQPIPRTIHRELLGISSISLPFQGADFWTLYELSWL 65

Query: 66  NAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQG 125
           N  GLPQVA+G + +D TS NLIES+S KLYLNS NQT F++  E+R TL  D++ C   
Sbjct: 66  NKYGLPQVAIGEMIIDATSDNLIESQSLKLYLNSINQTCFSSEQELRNTLITDITKCINS 125

Query: 126 KISVALYRLDELEGQPIGHFNGTCIDDQDITIDN--YEFTTDYLENATCGEKVVEETLVS 183
           ++ + ++ L +    PI  F G CID+Q I IDN  Y F ++ L N+   EKV +ETLVS
Sbjct: 126 QVKITIHSLSQWMTVPILEFTGECIDNQSIQIDNDNYIFNSNLLVNSVEREKV-KETLVS 184

Query: 184 HLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRF 243
           HLLKSNC IT+QPDWGS+QI Y G +I+RE LLRYL+SFR +  FHEQCVE+I+ D+++F
Sbjct: 185 HLLKSNCPITNQPDWGSVQISYYGMRINREALLRYLISFRKYKIFHEQCVEQIYCDIMQF 244

Query: 244 CQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           C P  LSVY RY RRGGLDINPWRSN  + P    L RQ
Sbjct: 245 CLPNTLSVYVRYNRRGGLDINPWRSNISYSPVNRPLARQ 283


>UniRef50_Q1K442 GTP cyclohydrolase I n=2 Tax=Proteobacteria RepID=Q1K442_DESAC
          Length = 275

 Score =  298 bits (762), Expect = 2e-79,   Method: Compositional matrix adjust.
 Identities = 148/273 (54%), Positives = 182/273 (66%), Gaps = 1/273 (0%)

Query: 10  LAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKG 69
           L  + LGK+T+Y   YDA LL  VPR L RD LG+ ++ LPF+G D+W  YELSWLN KG
Sbjct: 4   LTEIPLGKTTEYPSQYDAGLLYPVPRHLKRDELGI-SEPLPFYGEDVWNSYELSWLNRKG 62

Query: 70  LPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISV 129
            P VA+        S NL+ESKSFKLYLNS NQTRF++   V   L+RDLS  +   ++V
Sbjct: 63  KPVVALAVFRFSCQSPNLVESKSFKLYLNSLNQTRFDDQQAVIDCLQRDLSQASGSSVTV 122

Query: 130 ALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSN 189
            L  LD+     +    G C+D  D+ +++Y+   D L +A      VEETL SHLLKSN
Sbjct: 123 ELSSLDDQSLWQVQTLPGECLDSVDLDVEHYQLNADLLRDAADSADPVEETLYSHLLKSN 182

Query: 190 CLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKL 249
           CLIT QPDW S+ I YRG +++R  LL YL+SFR HNEFHEQCVERIF DL+R+C P+ L
Sbjct: 183 CLITSQPDWASVWISYRGGRLERRALLAYLISFRQHNEFHEQCVERIFADLMRYCHPQSL 242

Query: 250 SVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           +VYARYTRRGGLDINPWRS         RL RQ
Sbjct: 243 TVYARYTRRGGLDINPWRSTEPGTAPQWRLSRQ 275


>UniRef50_Q7WH69 NADPH-dependent 7-cyano-7-deazaguanine reductase n=5
           Tax=Proteobacteria RepID=QUEF_BORBR
          Length = 273

 Score =  283 bits (724), Expect = 4e-75,   Method: Compositional matrix adjust.
 Identities = 146/278 (52%), Positives = 177/278 (63%), Gaps = 10/278 (3%)

Query: 9   ALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAK 68
           +L+   LG+   Y   YD  LL  +PR+ NR  L L A  LPF G D+W  YELSWL+A+
Sbjct: 2   SLSNAPLGQHVAYPSQYDPGLLFPIPRATNRASLQLGA-TLPFTGVDLWNAYELSWLDAR 60

Query: 69  GLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKIS 128
           G P+VA+        S N++ESKSFKLYLNSFNQTR  N   +R  LERDL+  A   + 
Sbjct: 61  GKPRVAMATFSFPADSPNIVESKSFKLYLNSFNQTRLPNAQALRDRLERDLAAAAGAPVG 120

Query: 129 ---VALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHL 185
              ++  R  EL    +   +G  ID  DI ID YE     L+ A   E  VEETL + L
Sbjct: 121 LEFISPQRFGELN---MAELDGIYIDKLDIEIDTYEPAPQLLQCAPGDE--VEETLATRL 175

Query: 186 LKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQ 245
           LKSNC +T QPDW SLQ++YRGR IDR  LL+Y+VSFR H EFHE CVERIF D++R CQ
Sbjct: 176 LKSNCPVTGQPDWASLQVRYRGRPIDRAALLKYVVSFRQHAEFHEHCVERIFGDIMRACQ 235

Query: 246 PEKLSVYARYTRRGGLDINPWRSNSDFVPST-TRLVRQ 282
           P +L+VYARYTRRGGLDINPWRSN +  P    R  RQ
Sbjct: 236 PRQLTVYARYTRRGGLDINPWRSNFESAPPADVRTARQ 273


>UniRef50_A4VK37 GTP cyclohydrolase I, putative n=2 Tax=Gammaproteobacteria
           RepID=A4VK37_PSEU5
          Length = 298

 Score =  282 bits (722), Expect = 7e-75,   Method: Compositional matrix adjust.
 Identities = 140/268 (52%), Positives = 175/268 (65%), Gaps = 1/268 (0%)

Query: 15  LGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVA 74
           LGKS+DY  TY   LL  +PR+     LGL A+ LP+ G D+W  YELSWL   G P VA
Sbjct: 32  LGKSSDYVATYSPGLLFPIPRAPKWVELGLTAETLPYQGVDLWNCYELSWLLPSGKPVVA 91

Query: 75  VGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRL 134
           +G  E+   S ++IESKSFKLYLNS NQ+ F + + + + +  DLS  A   + V L  L
Sbjct: 92  IGEFEIPADSPSIIESKSFKLYLNSLNQSVFESREALAEVMSSDLSAAAGKPVKVRLRTL 151

Query: 135 DELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITH 194
           DE+  + +    G C+DD D+TI++Y+     L     G  +VEE+L SHLLKSNC +T 
Sbjct: 152 DEVAAEGVATLPGRCVDDLDVTIEHYDHPQPGLLACDAGH-MVEESLHSHLLKSNCPVTG 210

Query: 195 QPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYAR 254
           QPDWGS+ ++YRG  +  E LL YLVSFR H +FHEQCVERIF DL R  QPEKL+VYAR
Sbjct: 211 QPDWGSVVVEYRGAALQAESLLAYLVSFRQHADFHEQCVERIFLDLQRLLQPEKLTVYAR 270

Query: 255 YTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           Y RRGGLDINP+RS    V    RLVRQ
Sbjct: 271 YVRRGGLDINPYRSTGAMVVDNRRLVRQ 298


>UniRef50_Q5P6G9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=1
           Tax=Aromatoleum aromaticum EbN1 RepID=QUEF_AZOSE
          Length = 283

 Score =  277 bits (709), Expect = 2e-73,   Method: Compositional matrix adjust.
 Identities = 143/267 (53%), Positives = 178/267 (66%), Gaps = 2/267 (0%)

Query: 6   NHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWL 65
           +H A A   LG+S  YRD+Y   LL  + R + RD LGL  D LPF G D+W  YELSWL
Sbjct: 8   DHGAEAS-PLGQSVVYRDSYAPELLFPIARQIKRDELGLAPDTLPFVGEDLWNAYELSWL 66

Query: 66  NAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQG 125
           N++G P  A+G   +  TS  LIESKS KLYLNSFNQ RF +   V  TL RDLST A  
Sbjct: 67  NSRGKPVAAIGTFRVPVTSPRLIESKSLKLYLNSFNQHRFVDPTLVHDTLTRDLSTAAGA 126

Query: 126 KISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHL 185
            ++V++  L     +  G+ +G  +D+ DI ID Y     +L++    ++V  ETL SHL
Sbjct: 127 PVAVSIEVLSRRPTRVFGYPHGVLLDEIDIEIDTYRTDPAFLQSDFNADEV-SETLYSHL 185

Query: 186 LKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQ 245
           LKSNCL+T QPDWG++ ++Y G  IDR  LLRY+VSFR HNEFHEQCVERIF D+LR C 
Sbjct: 186 LKSNCLVTGQPDWGTIVLRYIGPPIDRAGLLRYIVSFRSHNEFHEQCVERIFCDVLRRCA 245

Query: 246 PEKLSVYARYTRRGGLDINPWRSNSDF 272
           P  L+V+ARYTRRGGLDINP+RS   F
Sbjct: 246 PRHLAVWARYTRRGGLDINPFRSTGHF 272


>UniRef50_Q5X7D5 NADPH-dependent 7-cyano-7-deazaguanine reductase n=43 Tax=Bacteria
           RepID=QUEF_LEGPA
          Length = 285

 Score =  273 bits (698), Expect = 5e-72,   Method: Compositional matrix adjust.
 Identities = 134/271 (49%), Positives = 180/271 (66%), Gaps = 6/271 (2%)

Query: 15  LGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVA 74
           LG++ +Y   Y+   L  +PR+  R  + L  ++  F+G D W  YE+SWLN+KG P VA
Sbjct: 18  LGQTANYDSYYNPKRLYPIPRAPKRQEINLDPNSTTFYGFDCWNHYEVSWLNSKGKPVVA 77

Query: 75  VGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRL 134
           +  +  D  S  +IESKS KLY NS N + F + + V QT+ +DLS C   +++V +Y L
Sbjct: 78  MAVISYDCHSPCIIESKSLKLYFNSLNNSTFPDVETVVQTISKDLSHCIGSEVAVNVYPL 137

Query: 135 DELEGQPI-GHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLIT 193
            E+  Q I   F+G C+D  DI    Y    D+L  ++   K+VEE L S LLKSNCL+T
Sbjct: 138 SEIASQTIYAAFDGICLDKLDIECSVYHVMPDFLSTSS---KLVEEVLYSDLLKSNCLVT 194

Query: 194 HQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYA 253
           +QPDWGS+QI Y+G++I+ E LL+YL+SFR+HNEFHEQC+ERIF D++RFCQPE L+VY 
Sbjct: 195 NQPDWGSVQIIYKGKKINHEGLLKYLISFRNHNEFHEQCIERIFADIMRFCQPESLAVYG 254

Query: 254 RYTRRGGLDINPWRSNSD--FVPSTTRLVRQ 282
           RYTRRGGLDINP RS     F     RL+RQ
Sbjct: 255 RYTRRGGLDINPIRSTEPCAFDGQNIRLIRQ 285


>UniRef50_A4T050 GTP cyclohydrolase I n=2 Tax=Proteobacteria RepID=A4T050_POLSQ
          Length = 275

 Score =  268 bits (686), Expect = 1e-70,   Method: Compositional matrix adjust.
 Identities = 139/275 (50%), Positives = 176/275 (64%), Gaps = 2/275 (0%)

Query: 10  LAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLK-ADNLPFHGTDIWTLYELSWLNAK 68
           +A L LG+ST Y D YD SLL  +PR+ NR  LGLK    LPF G DIW  +ELSWLN K
Sbjct: 1   MATLPLGQSTQYPDQYDPSLLFPIPRTENRAKLGLKEGQALPFVGIDIWNAFELSWLNQK 60

Query: 69  GLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKIS 128
           G PQ+A+   ++   S N+IESKSFKLYLNS N  RF +  +V+  L  DLS  A  K++
Sbjct: 61  GKPQIALAEFQIPADSPNMIESKSFKLYLNSLNSARFEDEGQVKDRLITDLSAVAGSKVA 120

Query: 129 VALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKS 188
             ++  + +  + +   +G  +D  DI ID +      L         +E+ LVSHLLKS
Sbjct: 121 TRIHSTEAVSKKGMQEMSGILMDRLDIEIDPHLPADPSLLGVNESFGPIEQCLVSHLLKS 180

Query: 189 NCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEK 248
           NC +T QPDW S+QI+Y+GR I  E LLRYL+ FR   EFHE CVE IF D+ R C+PEK
Sbjct: 181 NCPVTGQPDWASVQIRYQGRPILEEGLLRYLIGFRQLGEFHEHCVETIFTDIKRQCKPEK 240

Query: 249 LSVYARYTRRGGLDINPWRSNSDFV-PSTTRLVRQ 282
           LSVYARYTRRGGLDINP+R++ +   P  TR  RQ
Sbjct: 241 LSVYARYTRRGGLDINPFRTDHNSPWPENTRHARQ 275


>UniRef50_Q21VW6 NADPH-dependent 7-cyano-7-deazaguanine reductase n=143
           Tax=Proteobacteria RepID=QUEF_RHOFD
          Length = 289

 Score =  259 bits (663), Expect = 5e-68,   Method: Compositional matrix adjust.
 Identities = 140/283 (49%), Positives = 176/283 (62%), Gaps = 17/283 (6%)

Query: 15  LGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVA 74
           LG++T Y D YDASLL  + R+  R  +G+    LPF G D+WT +ELSWLN +G PQVA
Sbjct: 9   LGQATAYLDQYDASLLFPIARATKRAEIGVTG-ALPFLGADMWTAFELSWLNLRGKPQVA 67

Query: 75  VGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLS-------------- 120
           +    +   S N+IESKSFKLYLNSFN TRF + D V+  L  DLS              
Sbjct: 68  LARFTVPCESPNIIESKSFKLYLNSFNNTRFADVDAVKARLRADLSEAVWRDAGKNVSPD 127

Query: 121 TCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEET 180
             A   I V L   +  + +PI   +G  +D  D+   +Y    D L      E  V E 
Sbjct: 128 AAAPPSIGVTLLLPELFDREPIYELDGLSLDRLDVECTHYTPAPDLLR-VVPDEAPVSEV 186

Query: 181 LVSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDL 240
           LVS+LLKSNC +T QPDW S+QI Y G  ID+E LL+YLVSFR+HNEFHEQCVERIF DL
Sbjct: 187 LVSNLLKSNCPVTGQPDWASVQISYSGAPIDQEGLLQYLVSFRNHNEFHEQCVERIFMDL 246

Query: 241 LRFCQPEKLSVYARYTRRGGLDINPWRSN-SDFVPSTTRLVRQ 282
              C+P +L+VYARYTRRGGLDINP+R++ +  +P+  R  RQ
Sbjct: 247 WTRCKPVRLAVYARYTRRGGLDINPFRTSYAQALPANVRNARQ 289


>UniRef50_Q6ARX8 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2
           Tax=Proteobacteria RepID=QUEF_DESPS
          Length = 276

 Score =  257 bits (657), Expect = 2e-67,   Method: Compositional matrix adjust.
 Identities = 134/274 (48%), Positives = 175/274 (63%), Gaps = 6/274 (2%)

Query: 11  AGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGL 70
           AG+ LGK   + +TYD S L  V R   R  LGL AD+LPF G DIW  YELSWL++KG 
Sbjct: 7   AGIPLGKQVGHSETYDPSHLFPVARREARKSLGL-ADDLPFSGPDIWNAYELSWLDSKGK 65

Query: 71  PQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVA 130
           P VA+G +    TS N+IESKS KLYLNSFN TRF +   V++ +  DLS  A  ++ V 
Sbjct: 66  PCVALGEITFPCTSENIIESKSLKLYLNSFNLTRFTSTARVKEIIREDLSRVAGAEVEVK 125

Query: 131 LYRLDELEGQPIGHFNGTCIDDQDIT--IDNYEFTTDYLENATCGEKVVEETLVSHLLKS 188
           +   +E     I    G+CIDD ++   I+ Y  T +YL   + G +  EE L ++LL++
Sbjct: 126 ILTPEEFTEVTISAPEGSCIDDLELEEEINAYRPTANYL---STGPEETEEELYTNLLRT 182

Query: 189 NCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEK 248
           NC +T QPDW ++ I YRG+ ID+  LLRY++SFR H  FHE CVERIF D+L  C P +
Sbjct: 183 NCPVTGQPDWATVIINYRGKAIDQRGLLRYIISFRQHEGFHENCVERIFMDILNRCAPAR 242

Query: 249 LSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           L+VYAR+TRRGGLDINP+R+         RL RQ
Sbjct: 243 LTVYARFTRRGGLDINPYRTTHAEHFVNLRLARQ 276


>UniRef50_Q0VR70 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2
           Tax=Alcanivorax RepID=QUEF_ALCBS
          Length = 274

 Score =  253 bits (647), Expect = 4e-66,   Method: Compositional matrix adjust.
 Identities = 127/268 (47%), Positives = 174/268 (64%), Gaps = 2/268 (0%)

Query: 15  LGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVA 74
           LG+S++Y D Y  SLL  VPR   R+ L L++  LPFHG+DIW  YELSWLN KG P VA
Sbjct: 9   LGRSSEYVDQYMPSLLCPVPRWDAREGLELESATLPFHGSDIWNAYELSWLNEKGKPIVA 68

Query: 75  VGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRL 134
           +  + +  T+ N++ESKS KLYLNSF  TRF + D VR  +E+D++  A G I V L+ L
Sbjct: 69  MCELRVPCTTPNIVESKSLKLYLNSFANTRFQSRDAVRAAIEKDVAQTAGGNIEVLLFSL 128

Query: 135 DELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITH 194
            E  G P+    G C+D+ D+  ++YE+  D L      E+  +  L SHLL+S+C +T 
Sbjct: 129 QESAGFPVWEDRGDCVDNIDLNFEHYEYRPDLLLCDQGPEQTGQ--LYSHLLRSHCPVTD 186

Query: 195 QPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYAR 254
           QPDW ++ ++Y GR I     LRY+VS R+H  FHEQ +E++F DL+  C P  L+VY R
Sbjct: 187 QPDWATVVVRYTGRAISPASFLRYVVSLRNHQGFHEQIIEQMFVDLMTQCSPRHLTVYGR 246

Query: 255 YTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           +TRRGG+DINP+RSNS+      R +RQ
Sbjct: 247 FTRRGGIDINPFRSNSEQPLPNRRTIRQ 274


>UniRef50_P44165 Uncharacterized protein HI1340 n=9 Tax=Gammaproteobacteria
           RepID=Y1340_HAEIN
          Length = 441

 Score =  235 bits (599), Expect = 1e-60,   Method: Compositional matrix adjust.
 Identities = 126/261 (48%), Positives = 166/261 (63%), Gaps = 17/261 (6%)

Query: 9   ALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFH-GTDIWTLYELSWLNA 67
           +L  L LG+ T+Y   YD +LLQ VPR+LNRD LG+   N PF  G DIWT YE+SWLN 
Sbjct: 7   SLKSLKLGQKTEYASQYDRTLLQPVPRALNRDGLGI-TQNQPFTIGADIWTAYEISWLNE 65

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKI 127
           KGLPQVA+  + LDY S NLIESKSFKLYLNSFNQ++F +++ V+QT++RDLS CAQG +
Sbjct: 66  KGLPQVAIADIYLDYQSQNLIESKSFKLYLNSFNQSKFTDFNAVQQTMQRDLSECAQGDV 125

Query: 128 SVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLK 187
            V L  +   + Q I H  G CID+QDI I +YEF  ++L++    E +VEE LVSHLLK
Sbjct: 126 KVRLNPVAVYDAQKINHLQGDCIDEQDIEITSYEFNANWLKDCVSNE-IVEEKLVSHLLK 184

Query: 188 SNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIF----NDLLRF 243
           SNCLIT+QPDWG+ Q Q         KL     +F    +  EQ +  +     N+ L  
Sbjct: 185 SNCLITNQPDWGTDQAQQAILTARNNKL-----NFETQRKTAEQTLRNLLNLKPNEALNI 239

Query: 244 CQPEKLSVYARYTRRGGLDIN 264
             P  ++V     +  G+++N
Sbjct: 240 TFPHIMNV-----KTAGVNLN 255


>UniRef50_A8F0H9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=14
           Tax=Rickettsia RepID=QUEF_RICM5
          Length = 273

 Score =  231 bits (588), Expect = 3e-59,   Method: Compositional matrix adjust.
 Identities = 121/277 (43%), Positives = 173/277 (62%), Gaps = 6/277 (2%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNA 67
             L+   LGK + Y+D+YD +LL  +PR  NR+ LG+ ++NLPF+G D+W  YELS LN 
Sbjct: 1   MPLSTSLLGKKSTYKDSYDVTLLFKIPRINNRNELGINSNNLPFYGVDVWNTYELSCLNK 60

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKI 127
            G P V VG   +   S N++ESKSFKLYLNSFN     +  E+ + + +DLS     K+
Sbjct: 61  NGKPWVGVGTFYIPTDSENIVESKSFKLYLNSFNNFVVESVKELERIILQDLSNVTHAKV 120

Query: 128 SVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLK 187
           +  ++ ++       G  +G  IDD DI  +NY    + L      + +VEE + S+LLK
Sbjct: 121 TGRIFPINT--KVEFGVPSGKNIDDLDIVCNNYGAPDNSL--IEYEDVLVEEEINSNLLK 176

Query: 188 SNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           SNCL+T QPDWG++ I+Y+G+++  +  L+YL+SFR+ NEF EQC ERIF D+     P+
Sbjct: 177 SNCLVTGQPDWGTIVIKYKGKKLKHDSFLKYLISFRNCNEFAEQCAERIFTDIKNAISPD 236

Query: 248 KLSVYARYTRRGGLDINPWRS--NSDFVPSTTRLVRQ 282
            LS+   YTRRGG+DI P+RS   S  +PS  R +RQ
Sbjct: 237 FLSISIVYTRRGGIDICPYRSTDKSYTLPSDKRFIRQ 273


>UniRef50_C8PYF2 Queuine synthase n=3 Tax=Moraxellaceae RepID=C8PYF2_9GAMM
          Length = 283

 Score =  225 bits (574), Expect = 1e-57,   Method: Compositional matrix adjust.
 Identities = 119/278 (42%), Positives = 166/278 (59%), Gaps = 14/278 (5%)

Query: 15  LGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVA 74
           LG+ST Y  TY   +L  +PR+L R  L L AD L   G D W ++E+SWLN+ G+ QVA
Sbjct: 10  LGQSTSYPKTYAPDMLYPIPRALGRAKLALPADALSI-GMDWWQVFEMSWLNSHGISQVA 68

Query: 75  VGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRL 134
           +  + +  TS  ++ESKS KLY NS N T F+N   V+  +E+DLS C +  +++ ++ +
Sbjct: 69  MVRLAIPATSDYIVESKSLKLYFNSLNFTEFDNQQAVKAAVEKDLSACLKTDVTLEIFEV 128

Query: 135 DELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVE---------ETLVSHL 185
           +     PI    G CID+    +DN       + +       V          + L SHL
Sbjct: 129 NIANSLPISAPQGDCIDN---ALDNSGKKIAIVSDVDSSSLTVADQGASDSQLQILHSHL 185

Query: 186 LKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQ 245
           L+SNC +T+QPDWG+L+IQ   + IDR  LL Y++SFR HN FHEQCVE+IF+DL +   
Sbjct: 186 LRSNCPVTNQPDWGTLEIQIDSQPIDRAGLLEYILSFRQHNGFHEQCVEQIFSDLTQAFA 245

Query: 246 PEKLSVYARYTRRGGLDINPWR-SNSDFVPSTTRLVRQ 282
           P+ L V A YTRRGG+DINP R S+   +P  +RL RQ
Sbjct: 246 PKTLMVRAWYTRRGGIDINPCRVSDISLLPPPSRLNRQ 283


>UniRef50_Q6FA61 NADPH-dependent 7-cyano-7-deazaguanine reductase n=16
           Tax=Acinetobacter RepID=QUEF_ACIAD
          Length = 271

 Score =  214 bits (545), Expect = 3e-54,   Method: Compositional matrix adjust.
 Identities = 120/269 (44%), Positives = 163/269 (60%), Gaps = 6/269 (2%)

Query: 15  LGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVA 74
           LGK T+Y  TY  S+L  + R   R+    + + +   G D W ++ELSWLN+  +PQVA
Sbjct: 8   LGKETEYPTTYSPSVLFPISRDAAREKYA-QIEGIS-QGKDWWHVFELSWLNSDNIPQVA 65

Query: 75  VGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRL 134
           +G + L  TS  LIESKS KLY NS N   F +  E+   +E+DLS  A  K+S+ L+ +
Sbjct: 66  IGRITLPATSPYLIESKSLKLYFNSLNFHVFASKQELIDLVEKDLSQAANAKVSLELFDV 125

Query: 135 DELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITH 194
           D LE   I   +G CIDD              L+     +   + TL SHLL+SNC +T 
Sbjct: 126 DSLE---ISKPSGMCIDDLKPERLESHPDASLLKLDANEQHDADVTLYSHLLRSNCPVTG 182

Query: 195 QPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYAR 254
           QPDWG++ I+Y GR+     +L Y++S+R HN FHEQCVE+I+ D+ +  QPEKL VYA 
Sbjct: 183 QPDWGTVFIRYTGRKHCYRSILAYIISYRQHNGFHEQCVEQIYADIWKNLQPEKLMVYAT 242

Query: 255 YTRRGGLDINPWR-SNSDFVPSTTRLVRQ 282
           YTRRGGLDINP R S+  ++P+  RL RQ
Sbjct: 243 YTRRGGLDINPCRVSDLSWMPNPIRLARQ 271


>UniRef50_A4A3I6 GTP cyclohydrolase I n=1 Tax=Congregibacter litoralis KT71
           RepID=A4A3I6_9GAMM
          Length = 272

 Score =  213 bits (542), Expect = 5e-54,   Method: Compositional matrix adjust.
 Identities = 119/273 (43%), Positives = 159/273 (58%), Gaps = 13/273 (4%)

Query: 12  GLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLP 71
           G  LG+     + YD SLL  VPRS  R    L        G DIW  YELSWL+A G+P
Sbjct: 11  GPLLGQQVVGSEQYDPSLLFPVPRSNAR--ASLPEQRFQGFGEDIWHAYELSWLSAAGMP 68

Query: 72  QVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVAL 131
           Q  VG   +  TS NLIESKS KLYLNS N  RF + +  RQT+ RDLS  A   +S+ L
Sbjct: 69  QAFVGTFAIPATSANLIESKSLKLYLNSLNNHRFTSAEAARQTIVRDLSEVAGAPVSLTL 128

Query: 132 YRLDE--LEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSN 189
              ++    G+      G+C+DD ++T+ +       L     G+ +    L +HL++S 
Sbjct: 129 GSPEDPAFRGE---DLPGSCLDDLEVTVPDA--ADPVLLTGVAGDGL----LYTHLMRSL 179

Query: 190 CLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKL 249
           C +T QPDW ++ ++ RG   +   LLRYL+++R+H EFHEQCVERI+ D+L   QP+ L
Sbjct: 180 CPVTAQPDWATVVVETRGVAPESPGLLRYLLAYRNHQEFHEQCVERIYTDILDRLQPDYL 239

Query: 250 SVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           SV+A YTRRGGLDI+PWR +        RL RQ
Sbjct: 240 SVHALYTRRGGLDISPWRCSEHQPAPRYRLNRQ 272


>UniRef50_Q1QDK8 NADPH-dependent 7-cyano-7-deazaguanine reductase n=3
           Tax=Psychrobacter RepID=QUEF_PSYCK
          Length = 285

 Score =  207 bits (527), Expect = 3e-52,   Method: Compositional matrix adjust.
 Identities = 116/285 (40%), Positives = 170/285 (59%), Gaps = 12/285 (4%)

Query: 9   ALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAK 68
           ++ G+   ++TDY   Y    L  + RS+ R+ +G + D L   G D W  +ELSWLN +
Sbjct: 2   SIHGILGEQTTDYPTEYSPETLYPIARSMGREVIGWQDDKLEV-GFDWWQAFELSWLNEQ 60

Query: 69  GLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKIS 128
           G+ QVA+    +  +S  ++ESKS KLYLNS N T F + + V+  + +DLS C Q +++
Sbjct: 61  GISQVAIARFGIPASSPFIVESKSLKLYLNSINFTEFGSLETVQTLIAKDLSKCVQAEVN 120

Query: 129 VALYRL-DELEGQPIGHFNGTCIDDQDI-TIDNYEFT----TDYLENATCGEKVVEE--- 179
           V L+ L DE  G  I   +G CIDD    + +    T       LE  T   K+ E    
Sbjct: 121 VELFDLEDEHSGLLIAQPDGICIDDALADSTEKVALTLHPDASLLERNTSDAKISEGKTF 180

Query: 180 TLVSHLLKSNCLITHQPDWGSLQIQY-RGRQIDREKLLRYLVSFRHHNEFHEQCVERIFN 238
           +  S+LL+SNC +T+QPDWG+L +     + ++   +LRY++SFR HN FHEQCVE+IF 
Sbjct: 181 SFYSNLLRSNCPVTNQPDWGTLAVSITSNKPVNNANMLRYILSFRQHNGFHEQCVEQIFA 240

Query: 239 DLLRFCQPEKLSVYARYTRRGGLDINPWR-SNSDFVPSTTRLVRQ 282
           DL ++ +P +L V A YTRRGG+DINP R S+   +P  +RL+RQ
Sbjct: 241 DLSQYYEPSELMVRAWYTRRGGIDINPCRVSDIALLPVPSRLIRQ 285


>UniRef50_B8KG68 NADPH-dependent 7-cyano-7-deazaguanine reductase (Nadph-dependent
           nitrile oxidoreductase) n=1 Tax=gamma proteobacterium
           NOR5-3 RepID=B8KG68_9GAMM
          Length = 276

 Score =  201 bits (510), Expect = 3e-50,   Method: Compositional matrix adjust.
 Identities = 113/273 (41%), Positives = 156/273 (57%), Gaps = 13/273 (4%)

Query: 12  GLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLP 71
           G  LG+       YD  LL  VPR+  R    L        G DIW  YELSWLNA G+P
Sbjct: 15  GPLLGRQVAGSHYYDPGLLFPVPRANARK--SLPGGAFAGFGEDIWHAYELSWLNASGMP 72

Query: 72  QVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVAL 131
           Q+ +G   +   S N+IESKSFKLYLNS N   F +    R+T+ RDLS  A  ++S+ L
Sbjct: 73  QMFLGTFSVPADSANIIESKSFKLYLNSLNNFEFASDGLARETIVRDLSAVAGAQVSLVL 132

Query: 132 YRLDE--LEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSN 189
             +D+   +G+ +    G C+D   +++   E   + LE      +V      +HL++S 
Sbjct: 133 KAVDDQRYDGRVL---EGDCLDGFQVSVPE-EPHVELLEPVVGDARVY-----THLMRSL 183

Query: 190 CLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKL 249
           C +T QPDW ++ I+ RG    R+KLL YL+++R+H EFHEQCVER++ DL +  +P+ L
Sbjct: 184 CPVTAQPDWATMIIETRGTSAQRDKLLSYLLAYRNHQEFHEQCVERVYTDLWKRLEPDYL 243

Query: 250 SVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           SV A YTRRGGLDI PWR +        R+ RQ
Sbjct: 244 SVQALYTRRGGLDICPWRCSEARPAPQGRMNRQ 276


>UniRef50_B8KRQ4 NADPH-dependent 7-cyano-7-deazaguanine reductase n=1 Tax=gamma
           proteobacterium NOR51-B RepID=B8KRQ4_9GAMM
          Length = 267

 Score =  180 bits (457), Expect = 4e-44,   Method: Compositional matrix adjust.
 Identities = 102/270 (37%), Positives = 139/270 (51%), Gaps = 8/270 (2%)

Query: 14  TLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQV 73
            LG   D    Y   +L+ V R    + L       P  G D+W LYELSWL+ +G P  
Sbjct: 5   VLGSRVDAPTRYSPEILEPVERQRGDERLS------PMLGADVWHLYELSWLSREGWPTA 58

Query: 74  AVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYR 133
            VG + +  +S   +ESKS KLYLNS N  RF+N      T+ RD+       + + +  
Sbjct: 59  FVGALAIPASSPRTVESKSLKLYLNSLNFHRFDNERAAVSTIMRDVQAVVGASVDLTIAA 118

Query: 134 LDELEGQPIGHFNGTCIDDQ-DITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLI 192
             EL  Q      G CIDD     +   ++        + GE  V ETL+SH L+S C +
Sbjct: 119 PTEL-AQWTREPAGVCIDDVFSGALVAADWGASRKTPFSQGEDRVSETLISHQLRSLCPV 177

Query: 193 THQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVY 252
           T QPDWG+L + Y G ++D  +LL ++ SFR H +FHE CVE+I+  L     PE L+V 
Sbjct: 178 TGQPDWGTLVVDYSGYRLDPAELLSFVCSFREHQDFHEHCVEQIYKKLFGDLSPEALTVT 237

Query: 253 ARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           A Y RRGG+DI PWR +        R+ RQ
Sbjct: 238 AYYQRRGGIDITPWRGHEKLDAPLWRMGRQ 267


>UniRef50_A0Z1W1 Putative uncharacterized protein n=1 Tax=marine gamma
           proteobacterium HTCC2080 RepID=A0Z1W1_9GAMM
          Length = 267

 Score =  179 bits (454), Expect = 8e-44,   Method: Compositional matrix adjust.
 Identities = 104/273 (38%), Positives = 147/273 (53%), Gaps = 6/273 (2%)

Query: 10  LAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKG 69
           +A   LG+       Y   +L+ + R   R+ LG    ++  H  D W LYELSWLN + 
Sbjct: 1   MAVHALGQKVAAPKRYAPDILEAISRREGREALGPAPKSMVGH--DCWHLYELSWLNLRN 58

Query: 70  LPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISV 129
            PQ  VG + +D  S   IESKS KLYLNS N   F +  +  + +  D+    Q  +S+
Sbjct: 59  EPQHCVGVLLVDSASPATIESKSLKLYLNSLNFHCFASEAQACEVICGDIGRVTQSDVSL 118

Query: 130 ALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSN 189
            +   D L G       G  ++      D+    + + ++   G+ +++ T VSH L+S 
Sbjct: 119 TVLPPDGL-GAITREPEGVLLEADPQQSDHTSMQSPWCDS---GDDILDATYVSHRLRSL 174

Query: 190 CLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKL 249
           C +T QPDWG+L I YRGR I+  +LL ++ SFR H EFHEQCVER F ++++    E L
Sbjct: 175 CPVTAQPDWGTLVIDYRGRPINHHRLLGFIESFREHQEFHEQCVERCFYEVMKQTNAESL 234

Query: 250 SVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
            V A Y RRGG+DI P RSN   VP   R+ RQ
Sbjct: 235 RVSAFYQRRGGIDITPVRSNHRVVPELWRMGRQ 267


>UniRef50_B7RUV0 GTP cyclohydrolase I subfamily, putative n=1 Tax=marine gamma
           proteobacterium HTCC2148 RepID=B7RUV0_9GAMM
          Length = 168

 Score =  153 bits (387), Expect = 5e-36,   Method: Compositional matrix adjust.
 Identities = 79/174 (45%), Positives = 113/174 (64%), Gaps = 8/174 (4%)

Query: 111 VRQTLERDLSTCAQGKISVALYRLD--ELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLE 168
           +R+TL++D+       I + L  +D  EL+G   G  +G CIDD  I+ID+     + L+
Sbjct: 1   MRETLKKDIENTVGASIELELLPVDAVELDG---GIPDGLCIDDLQISIDSSPPGVNLLQ 57

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEF 228
               GE++VEE + SHLL+S C +T QPDW ++ ++YRGR +  E LLRYL++FR H EF
Sbjct: 58  ---AGEELVEEAVYSHLLRSLCPVTGQPDWATVYVRYRGRALTHESLLRYLIAFRKHQEF 114

Query: 229 HEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           HEQCVER++ D+ +   PE L + A YTRRGGLDINP+RS+       +R+ RQ
Sbjct: 115 HEQCVERMYCDIHKLVSPEFLEIQAFYTRRGGLDINPFRSSDANPIPLSRMNRQ 168


>UniRef50_Q6WI29 GTP cyclohydrolase I family protein n=1 Tax=Vibrio phage KVP40
           RepID=Q6WI29_BPKV4
          Length = 302

 Score =  144 bits (364), Expect = 2e-33,   Method: Compositional matrix adjust.
 Identities = 103/286 (36%), Positives = 142/286 (49%), Gaps = 28/286 (9%)

Query: 1   MSSYANHQALAGLTLGK-STDYRDTYD-----ASLLQGVPRSLNRDPLGLKADNLPFHGT 54
           MS+Y    A+A   LGK + DY D  D       LL  +PR LNR   G+   N  F G 
Sbjct: 1   MSNYDQVSAIAAEHLGKKAGDYSDFVDIVEVRPDLLVPIPRELNRTDYGIT--NEDFAGF 58

Query: 55  DIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQ-----TRFNNWD 109
           D W  +E+S L  +GLP   +  V     S N++ESKS KLY NSFN      TR    D
Sbjct: 59  DTWHGFEVSALTEQGLPVSGMAKVVYPSDSPNIVESKSMKLYWNSFNMAKVAATRAEVKD 118

Query: 110 EVRQTLERDLSTCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLEN 169
            +     RDLS      + V+ +   E   QP G    T   + D  +     +T +   
Sbjct: 119 AIEAIASRDLSEVIGAPVQVSFFT--EKLTQPHGM---TGFAELDKYVSE---STVFDSE 170

Query: 170 ATCGEKVVEETLVSHL------LKSNCLITHQPDWGSLQIQYRGRQIDR-EKLLRYLVSF 222
           +     +++E+ +  L      L+SNC +THQPD+G L +   G +    + L++Y+VSF
Sbjct: 171 SGADADLLQESHIKKLKVFTPNLRSNCRVTHQPDFGDLYVYMSGEKTPTVDSLMQYIVSF 230

Query: 223 RHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRS 268
           R  N FHE+CVE I+  LL    P +L V A YTRRGG +I P R+
Sbjct: 231 RKENHFHEECVEMIYKALLDKFDPTELMVTALYTRRGGWNICPARA 276


>UniRef50_Q9ZJJ9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=12
           Tax=Helicobacter RepID=QUEF_HELPJ
          Length = 148

 Score = 73.9 bits (180), Expect = 6e-12,   Method: Compositional matrix adjust.
 Identities = 38/111 (34%), Positives = 61/111 (54%), Gaps = 4/111 (3%)

Query: 160 YEFTTDYLENATCGEKVVEE--TLVSHLLKSNCLITHQPDWGSLQIQY--RGRQIDREKL 215
           +E+ +D LE        ++   TL      S C IT QPD+G + I+Y  + + ++ + L
Sbjct: 18  FEYNSDLLEAFPNPNPNLDPLITLECKEFTSLCPITSQPDFGVIFIRYIPKDKMVESKSL 77

Query: 216 LRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW 266
             YL S+R+H  FHE C+  I  DL++  +P+ L VY  +  RGG+ I P+
Sbjct: 78  KLYLFSYRNHGSFHESCINTILLDLVQLLEPKYLEVYGDFVSRGGIAIKPF 128


>UniRef50_A9VKS1 NADPH-dependent 7-cyano-7-deazaguanine reductase n=310 Tax=Bacteria
           RepID=QUEF_BACWK
          Length = 165

 Score = 73.2 bits (178), Expect = 1e-11,   Method: Compositional matrix adjust.
 Identities = 38/113 (33%), Positives = 56/113 (49%), Gaps = 13/113 (11%)

Query: 156 TIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQY--RGRQIDRE 213
             DN     DY     C E             S C  T QPD+ ++ I Y    R ++ +
Sbjct: 33  VFDNNHPNRDYFVKFNCPE-----------FTSLCPKTGQPDFATIYISYIPEQRMVESK 81

Query: 214 KLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW 266
            L  YL SFR+H +FHE C+  I NDL++   P  + V+ ++T RGG+ I+P+
Sbjct: 82  SLKLYLFSFRNHGDFHEDCMNVIMNDLIKLMDPRYIEVWGKFTPRGGISIDPY 134


>UniRef50_Q6MRJ2 NADPH-dependent 7-cyano-7-deazaguanine reductase n=1
           Tax=Bdellovibrio bacteriovorus RepID=QUEF_BDEBA
          Length = 170

 Score = 72.0 bits (175), Expect = 2e-11,   Method: Compositional matrix adjust.
 Identities = 34/94 (36%), Positives = 53/94 (56%), Gaps = 2/94 (2%)

Query: 175 KVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHNEFHEQC 232
           K+   T V     S C  T QPD+  + I Y    + ++ + L  YL SFR+H +FHE C
Sbjct: 43  KIAWTTFVCTEFTSLCPKTRQPDFAKIFINYIADKKMVESKSLKLYLFSFRNHGDFHEDC 102

Query: 233 VERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW 266
           V+ I +DL++  +P+ + V   +T RGG+ I P+
Sbjct: 103 VQTICDDLVKLMKPKYIEVIGEFTPRGGIAIYPY 136


>UniRef50_Q8DNP8 NADPH-dependent 7-cyano-7-deazaguanine reductase n=26
           Tax=Streptococcus pneumoniae RepID=QUEF_STRR6
          Length = 154

 Score = 68.2 bits (165), Expect = 3e-10,   Method: Compositional matrix adjust.
 Identities = 36/105 (34%), Positives = 59/105 (56%), Gaps = 4/105 (3%)

Query: 166 YLENATCGEKVVEETLVSHLLKSNCL--ITHQPDWGSLQIQYRGRQ--IDREKLLRYLVS 221
           +LE     E   E+ +  H+L  + L  IT QPD+ ++ I Y   +  ++ + L  YL S
Sbjct: 19  HLEIQITREIAKEQGIRHHILDMSLLGQITAQPDFATIHISYIPDKLCVESKSLKLYLFS 78

Query: 222 FRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW 266
           +R+H +FHE C+  I  DL+    P  L V+ ++T RGG+ I+P+
Sbjct: 79  YRNHGDFHENCINTIGKDLVNLLDPRYLEVWGKFTPRGGISIDPY 123


>UniRef50_C7M0Q2 7-cyano-7-deazaguanine reductase n=1 Tax=Acidimicrobium
           ferrooxidans DSM 10331 RepID=C7M0Q2_ACIFD
          Length = 155

 Score = 68.2 bits (165), Expect = 3e-10,   Method: Compositional matrix adjust.
 Identities = 34/82 (41%), Positives = 45/82 (54%), Gaps = 2/82 (2%)

Query: 188 SNCLITHQPDWGSLQIQY--RGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQ 245
           S C +T QPD+G L I Y    R ++ + L  YL+ FR+H  FHE CV ++  DL     
Sbjct: 50  SLCPVTGQPDYGQLDIVYVPGPRCVESKSLKLYLMRFRNHGAFHEACVAQVAQDLASVLA 109

Query: 246 PEKLSVYARYTRRGGLDINPWR 267
           P  L V  R+  RGG+ I P R
Sbjct: 110 PRYLRVIGRFNARGGIAIWPLR 131


>UniRef50_B3E3W5 7-cyano-7-deazaguanine reductase n=3 Tax=Proteobacteria
           RepID=B3E3W5_GEOLS
          Length = 144

 Score = 67.4 bits (163), Expect = 5e-10,   Method: Compositional matrix adjust.
 Identities = 34/78 (43%), Positives = 47/78 (60%), Gaps = 2/78 (2%)

Query: 190 CLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           C +T QPD+G++ I Y+   R ++ + L  YL SFR H EFHE  V RI NDL++   P 
Sbjct: 60  CPMTGQPDFGTIIIDYQPDQRCVESKSLKLYLGSFRMHGEFHEAGVNRICNDLVKLLDPV 119

Query: 248 KLSVYARYTRRGGLDINP 265
            L+V   +T RGG+   P
Sbjct: 120 WLTVKGEFTPRGGIPFWP 137


>UniRef50_D1N404 7-cyano-7-deazaguanine reductase n=3 Tax=Bacteria
           RepID=D1N404_9BACT
          Length = 142

 Score = 62.8 bits (151), Expect = 1e-08,   Method: Compositional matrix adjust.
 Identities = 31/79 (39%), Positives = 47/79 (59%), Gaps = 2/79 (2%)

Query: 188 SNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQ 245
           S C +T QPD+G + ++Y   +  I+ + L  YL SFR+ N FHE+ V  I + +++ C 
Sbjct: 54  SLCPVTGQPDFGHIILRYVPDKLCIESKSLKLYLYSFRNTNTFHEESVNTILDAVVKTCA 113

Query: 246 PEKLSVYARYTRRGGLDIN 264
           P K  V  R+  RGG+ IN
Sbjct: 114 PRKAEVIGRFRPRGGIAIN 132


>UniRef50_D2L9R9 7-cyano-7-deazaguanine reductase n=1 Tax=Desulfovibrio sp. FW1012B
           RepID=D2L9R9_9DELT
          Length = 145

 Score = 62.4 bits (150), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 32/87 (36%), Positives = 45/87 (51%), Gaps = 2/87 (2%)

Query: 180 TLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHNEFHEQCVERIF 237
           T  S    S C  T QPD+G + I+Y    R I+ + L  YL S+R    F E    RI 
Sbjct: 51  TFASEEFTSLCPKTGQPDFGMITIRYVPDERCIESKSLKLYLFSYRDEGTFMETLTNRIL 110

Query: 238 NDLLRFCQPEKLSVYARYTRRGGLDIN 264
           +DL+  CQP ++ V   +  RGG+ I+
Sbjct: 111 DDLVAACQPLEMEVTGDFAARGGITIS 137


>UniRef50_C4XPJ6 Putative uncharacterized protein n=1 Tax=Desulfovibrio magneticus
           RS-1 RepID=C4XPJ6_DESMR
          Length = 143

 Score = 60.5 bits (145), Expect = 6e-08,   Method: Compositional matrix adjust.
 Identities = 31/87 (35%), Positives = 45/87 (51%), Gaps = 2/87 (2%)

Query: 180 TLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEFHEQCVERIF 237
           T  S    S C  T QPD+G++ I+Y   +  I+ + L  YL S+R    F E    RI 
Sbjct: 47  TFASDEFTSLCPKTGQPDFGTITIRYVPDKLCIESKSLKLYLFSYRDEGAFMETLTNRIL 106

Query: 238 NDLLRFCQPEKLSVYARYTRRGGLDIN 264
           +DL+  CQP  + V   +  RGG+ I+
Sbjct: 107 DDLVEVCQPHHMEVTGDFAARGGITIS 133


>UniRef50_Q2J7K4 NADPH-dependent 7-cyano-7-deazaguanine reductase n=4
           Tax=Actinomycetales RepID=QUEF_FRASC
          Length = 125

 Score = 60.5 bits (145), Expect = 6e-08,   Method: Compositional matrix adjust.
 Identities = 43/139 (30%), Positives = 61/139 (43%), Gaps = 28/139 (20%)

Query: 129 VALYRLDELEGQPIGHFNGTCIDD--QDITIDNYEFTTDYLENATCGEKVVEETLVSHLL 186
           +AL +L   E +         IDD  Q+I ID  EFT                       
Sbjct: 1   MALTKLGNPEAKADRSLETFPIDDTSQEIRIDCREFT----------------------- 37

Query: 187 KSNCLITHQPDWGSLQIQYR--GRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFC 244
              C IT QPDW +++I YR  GR ++ + L  YL +FR    FHE     I +DL+   
Sbjct: 38  -CRCPITGQPDWATIRIDYRPGGRGLETKSLKLYLETFREEGIFHEHLATLIRDDLVAAL 96

Query: 245 QPEKLSVYARYTRRGGLDI 263
            P +L+V   +  RGG+ +
Sbjct: 97  APVQLTVTVNFNARGGIAL 115


>UniRef50_B2UN89 7-cyano-7-deazaguanine reductase n=2 Tax=Verrucomicrobiaceae
           RepID=B2UN89_AKKM8
          Length = 136

 Score = 58.2 bits (139), Expect = 3e-07,   Method: Compositional matrix adjust.
 Identities = 32/93 (34%), Positives = 50/93 (53%), Gaps = 2/93 (2%)

Query: 173 GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEFHE 230
           G +    TL +H   S C +T QPD   L I Y   +  ++ + L  YL ++R++  F+E
Sbjct: 31  GTRPYTITLDTHEFSSLCPVTGQPDSCHLTITYVPAEKCVETKSLKYYLAAYRNYPAFNE 90

Query: 231 QCVERIFNDLLRFCQPEKLSVYARYTRRGGLDI 263
           Q V RI +DL+    P  L V  R++ RGG+ +
Sbjct: 91  QIVNRITDDLVAAISPRWLKVEGRFSPRGGIQL 123


>UniRef50_C7JB01 Queuosine biosynthesis protein QueF n=9 Tax=Alphaproteobacteria
           RepID=C7JB01_ACEP3
          Length = 178

 Score = 54.7 bits (130), Expect = 3e-06,   Method: Compositional matrix adjust.
 Identities = 30/79 (37%), Positives = 43/79 (54%), Gaps = 2/79 (2%)

Query: 188 SNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQ 245
           S C IT QPD+  + I Y   +  ++ + L  YL SFR+H  FHE C  +I N L+    
Sbjct: 74  SLCPITGQPDFAHIVIDYVPDKWIVESKSLKLYLTSFRNHGAFHEACSIQIANTLVERLA 133

Query: 246 PEKLSVYARYTRRGGLDIN 264
           P  L + A +  RGG+ I+
Sbjct: 134 PRWLRIGAYWYPRGGIPID 152


>UniRef50_A8ZUH0 GTP cyclohydrolase I n=2 Tax=Desulfobacteraceae RepID=A8ZUH0_DESOH
          Length = 134

 Score = 53.9 bits (128), Expect = 5e-06,   Method: Compositional matrix adjust.
 Identities = 28/88 (31%), Positives = 44/88 (50%), Gaps = 2/88 (2%)

Query: 186 LKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRF 243
             S C +T  PD+G + I+YR R   ++ + L  YL+ +R+   F+E  + RI NDL   
Sbjct: 46  FTSLCPMTGLPDYGCITIRYRPRHHIVELKSLKYYLLQYRNVGIFYEHVINRILNDLSGA 105

Query: 244 CQPEKLSVYARYTRRGGLDINPWRSNSD 271
             P  + V   +T RGG+      +  D
Sbjct: 106 VAPVWMEVSGEFTARGGITTTVTAATGD 133


>UniRef50_Q8UD54 NADPH-dependent 7-cyano-7-deazaguanine reductase n=45
           Tax=Alphaproteobacteria RepID=QUEF_AGRT5
          Length = 154

 Score = 53.5 bits (127), Expect = 7e-06,   Method: Compositional matrix adjust.
 Identities = 34/110 (30%), Positives = 50/110 (45%), Gaps = 13/110 (11%)

Query: 157 IDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREK 214
           + N    TDY+   T  E             S C +T QPD+  + I Y      ++ + 
Sbjct: 30  VPNGNAGTDYVVRFTAPE-----------FTSLCPMTGQPDFAHIVIDYIPGDFLVESKS 78

Query: 215 LLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDIN 264
           L  +L SFR+H  FHE C   I   L+   QP+ L + A +  RGG+ I+
Sbjct: 79  LKLFLQSFRNHGAFHEDCSVYIAKRLVELLQPKWLRIGAYWYPRGGIPID 128


>UniRef50_A6C8E2 Putative uncharacterized protein n=2 Tax=Planctomycetaceae
           RepID=A6C8E2_9PLAN
          Length = 121

 Score = 52.0 bits (123), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 33/108 (30%), Positives = 50/108 (46%), Gaps = 13/108 (12%)

Query: 156 TIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQI--DRE 213
           T +N     DY+    C E             S C  T QPD+G+L I Y   ++  + +
Sbjct: 13  TFENPHPHRDYVMETVCPE-----------FTSVCPKTGQPDYGTLIITYIPDKVCFELK 61

Query: 214 KLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGL 261
            L  YL S+R+   F+E    RI +DL+    P  + + A +T RGG+
Sbjct: 62  SLKMYLQSYRNVGAFYEDVTNRILDDLVAITDPRWMELRAEFTPRGGI 109


>UniRef50_Q0AAV5 NADPH-dependent 7-cyano-7-deazaguanine reductase n=11 Tax=Bacteria
           RepID=QUEF_ALHEH
          Length = 129

 Score = 50.1 bits (118), Expect = 9e-05,   Method: Compositional matrix adjust.
 Identities = 25/74 (33%), Positives = 39/74 (52%), Gaps = 2/74 (2%)

Query: 190 CLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           C  T QPD+ ++ + Y    R ++ + L  Y+ SFR    FHE     I +DL+R  +P 
Sbjct: 34  CPKTGQPDFATIHLDYVPDERCVELKSLKLYMWSFRDQGAFHEAITNEILDDLVRATEPR 93

Query: 248 KLSVYARYTRRGGL 261
            + V A +  RGG+
Sbjct: 94  YMKVTAEFYVRGGI 107


>UniRef50_B3QM19 NADPH-dependent 7-cyano-7-deazaguanine reductase n=4 Tax=Bacteria
           RepID=QUEF_CHLP8
          Length = 116

 Score = 49.7 bits (117), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 25/83 (30%), Positives = 43/83 (51%), Gaps = 2/83 (2%)

Query: 181 LVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEFHEQCVERIFN 238
           +V+    S C  T  PD+G++ I Y   +  I+ + L  Y + FR+   F+E     I +
Sbjct: 22  IVNPEFTSVCPKTGLPDFGTITITYVPDKSCIELKSLKYYFLEFRNAGIFYENITNTILD 81

Query: 239 DLLRFCQPEKLSVYARYTRRGGL 261
            L+  CQP+ ++V   +  RGG+
Sbjct: 82  HLVEACQPKSMTVKTDWNARGGI 104


>UniRef50_Q3SJI1 NADPH-dependent 7-cyano-7-deazaguanine reductase n=9 Tax=Bacteria
           RepID=QUEF_THIDA
          Length = 139

 Score = 48.9 bits (115), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 26/77 (33%), Positives = 40/77 (51%), Gaps = 2/77 (2%)

Query: 190 CLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           C  T QPD+ +L + Y   Q  ++ + L  Y+ SFR    FHE    RI +DL+    P 
Sbjct: 34  CPKTGQPDFATLVLDYIPNQACVELKSLKLYMWSFRDEGHFHEDVTNRILDDLVAATDPR 93

Query: 248 KLSVYARYTRRGGLDIN 264
            + + A++  RGG+  N
Sbjct: 94  YMRLTAKFYVRGGIFTN 110


>UniRef50_C1CXM3 Putative GTP cyclohydrolase I n=2 Tax=Deinococcus deserti VCD115
           RepID=C1CXM3_DEIDV
          Length = 155

 Score = 48.9 bits (115), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 31/116 (26%), Positives = 57/116 (49%), Gaps = 4/116 (3%)

Query: 150 IDDQDITI-DNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR 208
           +D  D+ + D + +       A  GE +  E +++      C  +  PD+G L+I+Y+ R
Sbjct: 20  LDAIDVAVLDTFAYVRQDDPAAYPGEPMDIE-IITDEFSPVCPWSGLPDFGRLEIRYQPR 78

Query: 209 Q--IDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLD 262
           +  ++ + L  YL S+R    +HE    R+  DL +   P  +++   Y  RGGL+
Sbjct: 79  EKCVELKSLKYYLTSYRFVGIYHEHATRRLLADLTQLLDPLSMTIRCDYGMRGGLN 134


>UniRef50_Q04RM8 NADPH-dependent 7-cyano-7-deazaguanine reductase n=6 Tax=Leptospira
           RepID=QUEF_LEPBJ
          Length = 133

 Score = 48.5 bits (114), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 25/74 (33%), Positives = 38/74 (51%), Gaps = 2/74 (2%)

Query: 190 CLITHQPDWGSLQIQY--RGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           C  T  PD+G + + Y    R I+ +    Y++S+R+   FHE  V +I  DL+    P+
Sbjct: 49  CPKTGLPDFGVIYVSYVPTKRCIELKSFKEYILSYRNVGVFHEFLVNKIMEDLIAAIDPK 108

Query: 248 KLSVYARYTRRGGL 261
            L V   Y  RGG+
Sbjct: 109 YLKVIGDYNARGGI 122


>UniRef50_Q2IH01 NADPH-dependent 7-cyano-7-deazaguanine reductase n=5 Tax=Bacteria
           RepID=QUEF_ANADE
          Length = 122

 Score = 48.5 bits (114), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 25/74 (33%), Positives = 40/74 (54%), Gaps = 2/74 (2%)

Query: 190 CLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           C +T QPD+ +++++Y    R ++ + L  YL SFR    FHE    RI +DL+    P 
Sbjct: 34  CPMTGQPDFATIRLRYVPAERCVELKSLKLYLWSFRDEGTFHEAVTNRICDDLVAALAPR 93

Query: 248 KLSVYARYTRRGGL 261
            + V   +  RGG+
Sbjct: 94  WIEVVGDFAVRGGI 107


>UniRef50_A8W229 ATP-dependent metalloprotease FtsH n=1 Tax=Bacillus
           selenitireducens MLS10 RepID=A8W229_9BACI
          Length = 135

 Score = 48.5 bits (114), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 24/77 (31%), Positives = 42/77 (54%), Gaps = 2/77 (2%)

Query: 190 CLITHQPDWGSLQIQY--RGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           C  T QPD+G ++I+Y  R + I+ + L  YL S+R    + E    +I +D++   +P 
Sbjct: 50  CPKTGQPDFGQVEIEYVPRNKCIESKSLKFYLWSYRDEGAYCESLAAQIADDVMAAIEPA 109

Query: 248 KLSVYARYTRRGGLDIN 264
           ++ V    T RGG+ + 
Sbjct: 110 RVKVMVHQTPRGGIQLE 126


>UniRef50_B5JRC9 7-cyano-7-deazaguanine reductase n=1 Tax=Verrucomicrobiae bacterium
           DG1235 RepID=B5JRC9_9BACT
          Length = 126

 Score = 48.1 bits (113), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 30/102 (29%), Positives = 50/102 (49%), Gaps = 2/102 (1%)

Query: 165 DYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSF 222
           D L+     E V   T+ S  L S+C IT QPD+ ++ I+Y  ++  I+ + L  +L  F
Sbjct: 15  DELDTFEAPEGVTTVTMTSDELTSSCPITGQPDFYNVSIEYAPKELCIESKSLKLFLWGF 74

Query: 223 RHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDIN 264
           R    F E+    I + +++   P +  V      RGG++I 
Sbjct: 75  RDKAMFAEKIAAVICDRVVQDISPRRCRVMTFQKARGGIEIE 116


>UniRef50_B2KDU6 NADPH-dependent 7-cyano-7-deazaguanine reductase n=4 Tax=Bacteria
           RepID=QUEF_ELUMP
          Length = 132

 Score = 48.1 bits (113), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 25/76 (32%), Positives = 41/76 (53%), Gaps = 2/76 (2%)

Query: 188 SNCLITHQPDWGSLQIQYRGRQI--DREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQ 245
           S C  T  PD+G + I Y   ++  + + L  YL+ +R    F E    +I +D+++ C+
Sbjct: 46  SVCPKTGLPDFGVITIDYIPDRLCLELKSLKYYLLEYRDMGIFMENIANKILDDVVKACK 105

Query: 246 PEKLSVYARYTRRGGL 261
           P+K  V   +T RGGL
Sbjct: 106 PKKAVVTGDFTPRGGL 121


>UniRef50_Q8GJN6 NADPH-dependent 7-cyano-7-deazaguanine reductase n=98 Tax=cellular
           organisms RepID=QUEF_SYNE7
          Length = 174

 Score = 48.1 bits (113), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 29/86 (33%), Positives = 41/86 (47%), Gaps = 2/86 (2%)

Query: 181 LVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHNEFHEQCVERIFN 238
            V+    S C +T QPD+  L + Y    R ++ + L  +L SFR+H  FHE C   I  
Sbjct: 63  FVAPEFTSLCPLTGQPDFAHLVLDYVPDQRLVESKSLKLFLGSFRNHGAFHENCTLTIAK 122

Query: 239 DLLRFCQPEKLSVYARYTRRGGLDIN 264
            L     P  L +   +  RGGL I+
Sbjct: 123 RLEEAMNPTWLRLGGYWYPRGGLPID 148


>UniRef50_C0GIY6 7-cyano-7-deazaguanine reductase n=1 Tax=Dethiobacter alkaliphilus
           AHT 1 RepID=C0GIY6_9FIRM
          Length = 130

 Score = 47.4 bits (111), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 29/87 (33%), Positives = 41/87 (47%), Gaps = 2/87 (2%)

Query: 180 TLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEFHEQCVERIF 237
            L S  + S C +T QPDW ++ I+Y   +  I+ + L  Y  SFR    F E    +I 
Sbjct: 32  VLESDEVTSLCPVTGQPDWETVIIEYEPDRYCIESKSLKLYFWSFRQEGVFCEGLAAQIA 91

Query: 238 NDLLRFCQPEKLSVYARYTRRGGLDIN 264
           ND+   C+P    V      RGG+ I 
Sbjct: 92  NDVHAACKPFFCKVTVIQKPRGGITIT 118


>UniRef50_B7J648 NADPH-dependent 7-cyano-7-deazaguanine reductase n=22 Tax=Bacteria
           RepID=QUEF_ACIF2
          Length = 141

 Score = 46.6 bits (109), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 25/74 (33%), Positives = 37/74 (50%), Gaps = 2/74 (2%)

Query: 190 CLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           C +T QPD+    + +   Q  ++ + L  YL SFR    FHE    RI +DL+    P 
Sbjct: 34  CPLTGQPDFAHFMLDFIPDQHNVELKSLKLYLWSFRDEGAFHEAMTNRIADDLIGLINPR 93

Query: 248 KLSVYARYTRRGGL 261
            L +  R+  RGG+
Sbjct: 94  YLRLLGRWYVRGGI 107


>UniRef50_A5IIZ4 NADPH-dependent 7-cyano-7-deazaguanine reductase n=7
           Tax=Thermotogaceae RepID=QUEF_THEP1
          Length = 137

 Score = 46.2 bits (108), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 28/101 (27%), Positives = 49/101 (48%), Gaps = 3/101 (2%)

Query: 164 TDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQY---RGRQIDREKLLRYLV 220
           TD+LE      K     + +    + C  +  PD G + I+Y    G+ ++ + L  Y V
Sbjct: 19  TDFLEAIDFDGKDEYIKIETDEFSAVCPFSGLPDIGRVIIEYYPDGGKIVELKSLKYYFV 78

Query: 221 SFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGL 261
           SFR+   + E+  +RI+ DL    + +++ V   Y  RGG+
Sbjct: 79  SFRNVGIYQEEATKRIYEDLKNLLKTDRIRVTVIYNIRGGI 119


>UniRef50_B3EMR0 NADPH-dependent 7-cyano-7-deazaguanine reductase n=9 Tax=Bacteria
           RepID=QUEF_CHLPB
          Length = 118

 Score = 45.8 bits (107), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 24/83 (28%), Positives = 43/83 (51%), Gaps = 2/83 (2%)

Query: 181 LVSHLLKSNCLITHQPDWGSLQIQYRGRQI--DREKLLRYLVSFRHHNEFHEQCVERIFN 238
           +V+    S C IT  PD+G++ I+Y   ++  + + L  Y + FR+   F+E     I +
Sbjct: 22  IVNPEFTSVCPITGLPDFGTITIRYIPDKVCVELKSLKYYYLEFRNAGIFYENVTNTILD 81

Query: 239 DLLRFCQPEKLSVYARYTRRGGL 261
            L+   +P  L+V   +  RGG+
Sbjct: 82  HLVDLLKPRTLTVTTAWKARGGI 104


>UniRef50_Q2LTJ0 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2 Tax=Bacteria
           RepID=QUEF_SYNAS
          Length = 140

 Score = 45.8 bits (107), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 25/77 (32%), Positives = 36/77 (46%), Gaps = 2/77 (2%)

Query: 190 CLITHQPDWGSLQIQY--RGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           C +T QPD+  L I Y      ++ + L  YL S+R+   FHE     I  D++    P 
Sbjct: 51  CPMTGQPDFADLHISYIPDASILESKSLKLYLWSYRNEGIFHEHVTNVILEDVVAALSPR 110

Query: 248 KLSVYARYTRRGGLDIN 264
              V A +  RGG+ I 
Sbjct: 111 WCKVTANFGVRGGISIT 127


>UniRef50_A1WY83 NADPH-dependent 7-cyano-7-deazaguanine reductase n=5 Tax=Bacteria
           RepID=QUEF_HALHL
          Length = 118

 Score = 44.7 bits (104), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 23/74 (31%), Positives = 39/74 (52%), Gaps = 2/74 (2%)

Query: 190 CLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           C  T QPD+ +L ++Y   +  ++ + L  Y+ S+R    FHE    +I  DL+   QP 
Sbjct: 34  CPKTGQPDFATLNLEYIPERHCVELKSLKLYIWSYRDVGGFHEALTNQILGDLVAATQPR 93

Query: 248 KLSVYARYTRRGGL 261
            + + A +  RGG+
Sbjct: 94  YMKLTAHFNVRGGI 107


>UniRef50_B0KAC5 NADPH-dependent 7-cyano-7-deazaguanine reductase n=11
           Tax=Clostridia RepID=QUEF_THEP3
          Length = 133

 Score = 44.7 bits (104), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 23/82 (28%), Positives = 41/82 (50%), Gaps = 2/82 (2%)

Query: 182 VSHLLKSNCLITHQPDWGSLQIQY--RGRQIDREKLLRYLVSFRHHNEFHEQCVERIFND 239
           +++   S C  T  PD   L I+Y    + ++ + L  YL S+R+     E  + RI +D
Sbjct: 40  ITNEFSSVCPWTGLPDNAKLTIRYIPSKKLVELKSLKYYLTSYRNVGILQEHAINRILDD 99

Query: 240 LLRFCQPEKLSVYARYTRRGGL 261
           L+   QP+ + +   +  RGG+
Sbjct: 100 LVELLQPKFMEIIGEFQERGGI 121


>UniRef50_B8IYG6 NADPH-dependent 7-cyano-7-deazaguanine reductase n=6
           Tax=Desulfovibrionaceae RepID=QUEF_DESDA
          Length = 167

 Score = 43.1 bits (100), Expect = 0.012,   Method: Compositional matrix adjust.
 Identities = 22/81 (27%), Positives = 37/81 (45%), Gaps = 2/81 (2%)

Query: 186 LKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRF 243
             S C +T QPD G++ ++Y   +  ++ +    Y+ +FR+H  F E     +  DL   
Sbjct: 53  FTSLCPVTGQPDCGTITVEYIPDELCVESKSFKLYMFAFRNHQSFMETITNNVLEDLRAL 112

Query: 244 CQPEKLSVYARYTRRGGLDIN 264
             P    V   +  RGG  I+
Sbjct: 113 LNPCWCRVKGLFAPRGGTRIH 133


>UniRef50_D2REX4 GTP cyclohydrolase I n=1 Tax=Archaeoglobus profundus DSM 5631
           RepID=D2REX4_ARCPR
          Length = 236

 Score = 42.4 bits (98), Expect = 0.017,   Method: Compositional matrix adjust.
 Identities = 24/74 (32%), Positives = 38/74 (51%), Gaps = 2/74 (2%)

Query: 190 CLITHQPDWGSLQIQYR--GRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           C +T   D G+++I+Y+   R ++ E L  Y   F      HE  V ++FND+ +   PE
Sbjct: 155 CPVTGLRDIGTIKIRYKPKDRILEYESLDSYFKLFADKKMHHEAVVCKVFNDIYQALNPE 214

Query: 248 KLSVYARYTRRGGL 261
            L V A +  R G+
Sbjct: 215 WLEVVAEFEERSGV 228


>UniRef50_B8HRW7 7-cyano-7-deazaguanine reductase n=2 Tax=Cyanobacteria
           RepID=B8HRW7_CYAP4
          Length = 142

 Score = 40.8 bits (94), Expect = 0.049,   Method: Compositional matrix adjust.
 Identities = 20/75 (26%), Positives = 39/75 (52%), Gaps = 2/75 (2%)

Query: 189 NCLITHQPDWGSLQIQY--RGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQP 246
            C  +  PD+ ++ + Y    R ++ + +  Y+ S+R     HE+ V +I +DL+  C P
Sbjct: 57  KCPFSGYPDFATIHVSYIPDQRVVELKAIKLYINSYRDRYISHEESVNQILDDLVTACDP 116

Query: 247 EKLSVYARYTRRGGL 261
            ++SV   +  RG +
Sbjct: 117 LQISVKGDFAPRGNV 131


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q0T1R0 NADPH-dependent 7-cyano-7-deazaguanine reductase...   475   e-133
UniRef50_Q0HGT5 NADPH-dependent 7-cyano-7-deazaguanine reductase...   427   e-118
UniRef50_Q1K442 GTP cyclohydrolase I n=2 Tax=Proteobacteria RepI...   412   e-113
UniRef50_Q7WH69 NADPH-dependent 7-cyano-7-deazaguanine reductase...   409   e-113
UniRef50_A4VK37 GTP cyclohydrolase I, putative n=2 Tax=Gammaprot...   406   e-112
UniRef50_A4T050 GTP cyclohydrolase I n=2 Tax=Proteobacteria RepI...   406   e-112
UniRef50_Q0VR70 NADPH-dependent 7-cyano-7-deazaguanine reductase...   401   e-110
UniRef50_Q5P6G9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   398   e-110
UniRef50_Q6ARX8 NADPH-dependent 7-cyano-7-deazaguanine reductase...   398   e-110
UniRef50_Q1LSV9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   388   e-106
UniRef50_Q5X7D5 NADPH-dependent 7-cyano-7-deazaguanine reductase...   388   e-106
UniRef50_Q21VW6 NADPH-dependent 7-cyano-7-deazaguanine reductase...   386   e-106
UniRef50_Q6FA61 NADPH-dependent 7-cyano-7-deazaguanine reductase...   372   e-102
UniRef50_A8F0H9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   370   e-101
UniRef50_A4A3I6 GTP cyclohydrolase I n=1 Tax=Congregibacter lito...   369   e-101
UniRef50_B8KG68 NADPH-dependent 7-cyano-7-deazaguanine reductase...   368   e-100
UniRef50_C8PYF2 Queuine synthase n=3 Tax=Moraxellaceae RepID=C8P...   365   e-100
UniRef50_Q1QDK8 NADPH-dependent 7-cyano-7-deazaguanine reductase...   360   3e-98
UniRef50_B8KRQ4 NADPH-dependent 7-cyano-7-deazaguanine reductase...   351   2e-95
UniRef50_A0Z1W1 Putative uncharacterized protein n=1 Tax=marine ...   350   3e-95
UniRef50_P44165 Uncharacterized protein HI1340 n=9 Tax=Gammaprot...   336   5e-91
UniRef50_Q6WI29 GTP cyclohydrolase I family protein n=1 Tax=Vibr...   301   1e-80
UniRef50_B7RUV0 GTP cyclohydrolase I subfamily, putative n=1 Tax...   228   2e-58
UniRef50_A9VKS1 NADPH-dependent 7-cyano-7-deazaguanine reductase...   157   3e-37
UniRef50_Q9ZJJ9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   154   4e-36
UniRef50_Q6MRJ2 NADPH-dependent 7-cyano-7-deazaguanine reductase...   149   8e-35
UniRef50_C4XPJ6 Putative uncharacterized protein n=1 Tax=Desulfo...   148   2e-34
UniRef50_B3E3W5 7-cyano-7-deazaguanine reductase n=3 Tax=Proteob...   145   1e-33
UniRef50_C7JB01 Queuosine biosynthesis protein QueF n=9 Tax=Alph...   145   2e-33
UniRef50_C7M0Q2 7-cyano-7-deazaguanine reductase n=1 Tax=Acidimi...   143   5e-33
UniRef50_D2L9R9 7-cyano-7-deazaguanine reductase n=1 Tax=Desulfo...   141   3e-32
UniRef50_Q8DNP8 NADPH-dependent 7-cyano-7-deazaguanine reductase...   140   7e-32
UniRef50_Q8GJN6 NADPH-dependent 7-cyano-7-deazaguanine reductase...   140   8e-32
UniRef50_Q2IH01 NADPH-dependent 7-cyano-7-deazaguanine reductase...   140   8e-32
UniRef50_A6C8E2 Putative uncharacterized protein n=2 Tax=Plancto...   139   9e-32
UniRef50_Q8UD54 NADPH-dependent 7-cyano-7-deazaguanine reductase...   139   1e-31
UniRef50_B2UN89 7-cyano-7-deazaguanine reductase n=2 Tax=Verruco...   137   3e-31
UniRef50_Q3SJI1 NADPH-dependent 7-cyano-7-deazaguanine reductase...   136   6e-31
UniRef50_Q2LTJ0 NADPH-dependent 7-cyano-7-deazaguanine reductase...   136   7e-31
UniRef50_D1N404 7-cyano-7-deazaguanine reductase n=3 Tax=Bacteri...   135   2e-30
UniRef50_Q0AAV5 NADPH-dependent 7-cyano-7-deazaguanine reductase...   135   2e-30
UniRef50_C0GIY6 7-cyano-7-deazaguanine reductase n=1 Tax=Dethiob...   134   3e-30
UniRef50_A8ZUH0 GTP cyclohydrolase I n=2 Tax=Desulfobacteraceae ...   132   1e-29
UniRef50_B3QM19 NADPH-dependent 7-cyano-7-deazaguanine reductase...   130   4e-29
UniRef50_Q2J7K4 NADPH-dependent 7-cyano-7-deazaguanine reductase...   130   6e-29
UniRef50_B3EMR0 NADPH-dependent 7-cyano-7-deazaguanine reductase...   129   1e-28
UniRef50_C1CXM3 Putative GTP cyclohydrolase I n=2 Tax=Deinococcu...   128   2e-28
UniRef50_B5JRC9 7-cyano-7-deazaguanine reductase n=1 Tax=Verruco...   127   5e-28
UniRef50_B7J648 NADPH-dependent 7-cyano-7-deazaguanine reductase...   125   3e-27
UniRef50_Q04RM8 NADPH-dependent 7-cyano-7-deazaguanine reductase...   123   7e-27
UniRef50_B2KDU6 NADPH-dependent 7-cyano-7-deazaguanine reductase...   122   1e-26
UniRef50_A8W229 ATP-dependent metalloprotease FtsH n=1 Tax=Bacil...   121   2e-26
UniRef50_A5IIZ4 NADPH-dependent 7-cyano-7-deazaguanine reductase...   117   3e-25

Sequences not found previously or not previously below threshold:

UniRef50_A1WY83 NADPH-dependent 7-cyano-7-deazaguanine reductase...   130   4e-29
UniRef50_B8DRK9 7-cyano-7-deazaguanine reductase n=2 Tax=Desulfo...   129   1e-28
UniRef50_B8IYG6 NADPH-dependent 7-cyano-7-deazaguanine reductase...   124   4e-27
UniRef50_B0KAC5 NADPH-dependent 7-cyano-7-deazaguanine reductase...   118   2e-25
UniRef50_Q8DMA3 NADPH-dependent 7-cyano-7-deazaguanine reductase...    99   1e-19
UniRef50_B8HRW7 7-cyano-7-deazaguanine reductase n=2 Tax=Cyanoba...    99   2e-19
UniRef50_B4U9Q5 7-cyano-7-deazaguanine reductase n=5 Tax=Bacteri...    98   3e-19
UniRef50_A6Q0W4 NADPH-dependent 7-cyano-7-deazaguanine reductase...    98   3e-19
UniRef50_B5IMF1 7-cyano-7-deazaguanine reductase n=1 Tax=Cyanobi...    98   3e-19
UniRef50_B0CDX9 NADPH-dependent 7-cyano-7-deazaguanine reductase...    97   7e-19
UniRef50_B5IBP5 7-cyano-7-deazaguanine reductase n=2 Tax=Aciduli...    96   1e-18
UniRef50_Q113I7 NADPH-dependent 7-cyano-7-deazaguanine reductase...    93   8e-18
UniRef50_D0MDN3 7-cyano-7-deazaguanine reductase n=1 Tax=Rhodoth...    92   1e-17
UniRef50_B7JWF0 7-cyano-7-deazaguanine reductase n=8 Tax=Cyanoba...    92   3e-17
UniRef50_D2REX4 GTP cyclohydrolase I n=1 Tax=Archaeoglobus profu...    87   8e-16
UniRef50_Q5HS73 NADPH-dependent 7-cyano-7-deazaguanine reductase...    83   7e-15
UniRef50_Q9YBX9 Putative GTP cyclohydrolase I n=1 Tax=Aeropyrum ...    56   1e-06
UniRef50_A2BLN0 Predicted GTP cyclohydrolase I n=1 Tax=Hyperther...    47   8e-04
UniRef50_B1SCE4 Putative uncharacterized protein n=1 Tax=Strepto...    46   0.002

>UniRef50_Q0T1R0 NADPH-dependent 7-cyano-7-deazaguanine reductase n=139
           Tax=Gammaproteobacteria RepID=QUEF_SHIF8
          Length = 282

 Score =  475 bits (1222), Expect = e-133,   Method: Composition-based stats.
 Identities = 280/282 (99%), Positives = 281/282 (99%)

Query: 1   MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLY 60
           MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLY
Sbjct: 1   MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLY 60

Query: 61  ELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLS 120
           ELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLS
Sbjct: 61  ELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLS 120

Query: 121 TCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEET 180
           TCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENAT GEKVVEET
Sbjct: 121 TCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATSGEKVVEET 180

Query: 181 LVSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDL 240
           LVSHLLKSNCLITHQPDWGS+QIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDL
Sbjct: 181 LVSHLLKSNCLITHQPDWGSIQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDL 240

Query: 241 LRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           LRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ
Sbjct: 241 LRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282


>UniRef50_Q0HGT5 NADPH-dependent 7-cyano-7-deazaguanine reductase n=142
           Tax=Proteobacteria RepID=QUEF_SHESM
          Length = 286

 Score =  427 bits (1099), Expect = e-118,   Method: Composition-based stats.
 Identities = 177/279 (63%), Positives = 219/279 (78%)

Query: 4   YANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELS 63
           Y++ + LAGLTLGK+TDY+  YDASLLQGVPRSLNR+ + L A++LPFHG DIWT YELS
Sbjct: 8   YSDAKELAGLTLGKATDYQAEYDASLLQGVPRSLNRNAINLTAESLPFHGADIWTAYELS 67

Query: 64  WLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCA 123
           WLNAKG P VA+  ++L + S NLIESKSFKLYLNSFNQT+F+N D V++TL +DLS CA
Sbjct: 68  WLNAKGKPMVAIADIQLSHESQNLIESKSFKLYLNSFNQTKFDNIDAVQKTLVQDLSECA 127

Query: 124 QGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVS 183
           QG+++V +        Q +    GTCIDD DI + +Y+F  DYLEN+T  +++V ETL S
Sbjct: 128 QGQVTVKIIEPKSFGIQRVVELPGTCIDDLDIEVSDYDFNPDYLENSTDDKQIVAETLNS 187

Query: 184 HLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRF 243
           +LLKSNCLIT QPDWGS+ I+Y+G +IDREKLLRYL+SFR HNEFHEQCVERIF DL  +
Sbjct: 188 NLLKSNCLITSQPDWGSVMIRYQGPKIDREKLLRYLISFRQHNEFHEQCVERIFVDLKHY 247

Query: 244 CQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           C   KL+VYARYTRRGGLDINP+RS+ +    + RL RQ
Sbjct: 248 CHCTKLTVYARYTRRGGLDINPYRSDFEHPGESHRLARQ 286


>UniRef50_Q1K442 GTP cyclohydrolase I n=2 Tax=Proteobacteria RepID=Q1K442_DESAC
          Length = 275

 Score =  412 bits (1058), Expect = e-113,   Method: Composition-based stats.
 Identities = 148/275 (53%), Positives = 182/275 (66%), Gaps = 1/275 (0%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNA 67
             L  + LGK+T+Y   YDA LL  VPR L RD LG+ ++ LPF+G D+W  YELSWLN 
Sbjct: 2   SDLTEIPLGKTTEYPSQYDAGLLYPVPRHLKRDELGI-SEPLPFYGEDVWNSYELSWLNR 60

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKI 127
           KG P VA+        S NL+ESKSFKLYLNS NQTRF++   V   L+RDLS  +   +
Sbjct: 61  KGKPVVALAVFRFSCQSPNLVESKSFKLYLNSLNQTRFDDQQAVIDCLQRDLSQASGSSV 120

Query: 128 SVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLK 187
           +V L  LD+     +    G C+D  D+ +++Y+   D L +A      VEETL SHLLK
Sbjct: 121 TVELSSLDDQSLWQVQTLPGECLDSVDLDVEHYQLNADLLRDAADSADPVEETLYSHLLK 180

Query: 188 SNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           SNCLIT QPDW S+ I YRG +++R  LL YL+SFR HNEFHEQCVERIF DL+R+C P+
Sbjct: 181 SNCLITSQPDWASVWISYRGGRLERRALLAYLISFRQHNEFHEQCVERIFADLMRYCHPQ 240

Query: 248 KLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
            L+VYARYTRRGGLDINPWRS         RL RQ
Sbjct: 241 SLTVYARYTRRGGLDINPWRSTEPGTAPQWRLSRQ 275


>UniRef50_Q7WH69 NADPH-dependent 7-cyano-7-deazaguanine reductase n=5
           Tax=Proteobacteria RepID=QUEF_BORBR
          Length = 273

 Score =  409 bits (1051), Expect = e-113,   Method: Composition-based stats.
 Identities = 143/276 (51%), Positives = 173/276 (62%), Gaps = 4/276 (1%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNA 67
            +L+   LG+   Y   YD  LL  +PR+ NR  L L A  LPF G D+W  YELSWL+A
Sbjct: 1   MSLSNAPLGQHVAYPSQYDPGLLFPIPRATNRASLQLGA-TLPFTGVDLWNAYELSWLDA 59

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKI 127
           +G P+VA+        S N++ESKSFKLYLNSFNQTR  N   +R  LERDL+  A   +
Sbjct: 60  RGKPRVAMATFSFPADSPNIVESKSFKLYLNSFNQTRLPNAQALRDRLERDLAAAAGAPV 119

Query: 128 SVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLK 187
            +            +   +G  ID  DI ID YE     L+ A   E  VEETL + LLK
Sbjct: 120 GLEFISPQRFGELNMAELDGIYIDKLDIEIDTYEPAPQLLQCAPGDE--VEETLATRLLK 177

Query: 188 SNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           SNC +T QPDW SLQ++YRGR IDR  LL+Y+VSFR H EFHE CVERIF D++R CQP 
Sbjct: 178 SNCPVTGQPDWASLQVRYRGRPIDRAALLKYVVSFRQHAEFHEHCVERIFGDIMRACQPR 237

Query: 248 KLSVYARYTRRGGLDINPWRSNSDFVPS-TTRLVRQ 282
           +L+VYARYTRRGGLDINPWRSN +  P    R  RQ
Sbjct: 238 QLTVYARYTRRGGLDINPWRSNFESAPPADVRTARQ 273


>UniRef50_A4VK37 GTP cyclohydrolase I, putative n=2 Tax=Gammaproteobacteria
           RepID=A4VK37_PSEU5
          Length = 298

 Score =  406 bits (1044), Expect = e-112,   Method: Composition-based stats.
 Identities = 142/277 (51%), Positives = 177/277 (63%), Gaps = 2/277 (0%)

Query: 6   NHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWL 65
            H A     LGKS+DY  TY   LL  +PR+     LGL A+ LP+ G D+W  YELSWL
Sbjct: 24  QHPAEHS-PLGKSSDYVATYSPGLLFPIPRAPKWVELGLTAETLPYQGVDLWNCYELSWL 82

Query: 66  NAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQG 125
              G P VA+G  E+   S ++IESKSFKLYLNS NQ+ F + + + + +  DLS  A  
Sbjct: 83  LPSGKPVVAIGEFEIPADSPSIIESKSFKLYLNSLNQSVFESREALAEVMSSDLSAAAGK 142

Query: 126 KISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHL 185
            + V L  LDE+  + +    G C+DD D+TI++Y+     L     G  +VEE+L SHL
Sbjct: 143 PVKVRLRTLDEVAAEGVATLPGRCVDDLDVTIEHYDHPQPGLLACDAG-HMVEESLHSHL 201

Query: 186 LKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQ 245
           LKSNC +T QPDWGS+ ++YRG  +  E LL YLVSFR H +FHEQCVERIF DL R  Q
Sbjct: 202 LKSNCPVTGQPDWGSVVVEYRGAALQAESLLAYLVSFRQHADFHEQCVERIFLDLQRLLQ 261

Query: 246 PEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           PEKL+VYARY RRGGLDINP+RS    V    RLVRQ
Sbjct: 262 PEKLTVYARYVRRGGLDINPYRSTGAMVVDNRRLVRQ 298


>UniRef50_A4T050 GTP cyclohydrolase I n=2 Tax=Proteobacteria RepID=A4T050_POLSQ
          Length = 275

 Score =  406 bits (1043), Expect = e-112,   Method: Composition-based stats.
 Identities = 139/275 (50%), Positives = 176/275 (64%), Gaps = 2/275 (0%)

Query: 10  LAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLK-ADNLPFHGTDIWTLYELSWLNAK 68
           +A L LG+ST Y D YD SLL  +PR+ NR  LGLK    LPF G DIW  +ELSWLN K
Sbjct: 1   MATLPLGQSTQYPDQYDPSLLFPIPRTENRAKLGLKEGQALPFVGIDIWNAFELSWLNQK 60

Query: 69  GLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKIS 128
           G PQ+A+   ++   S N+IESKSFKLYLNS N  RF +  +V+  L  DLS  A  K++
Sbjct: 61  GKPQIALAEFQIPADSPNMIESKSFKLYLNSLNSARFEDEGQVKDRLITDLSAVAGSKVA 120

Query: 129 VALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKS 188
             ++  + +  + +   +G  +D  DI ID +      L         +E+ LVSHLLKS
Sbjct: 121 TRIHSTEAVSKKGMQEMSGILMDRLDIEIDPHLPADPSLLGVNESFGPIEQCLVSHLLKS 180

Query: 189 NCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEK 248
           NC +T QPDW S+QI+Y+GR I  E LLRYL+ FR   EFHE CVE IF D+ R C+PEK
Sbjct: 181 NCPVTGQPDWASVQIRYQGRPILEEGLLRYLIGFRQLGEFHEHCVETIFTDIKRQCKPEK 240

Query: 249 LSVYARYTRRGGLDINPWRSNSDFV-PSTTRLVRQ 282
           LSVYARYTRRGGLDINP+R++ +   P  TR  RQ
Sbjct: 241 LSVYARYTRRGGLDINPFRTDHNSPWPENTRHARQ 275


>UniRef50_Q0VR70 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2
           Tax=Alcanivorax RepID=QUEF_ALCBS
          Length = 274

 Score =  401 bits (1031), Expect = e-110,   Method: Composition-based stats.
 Identities = 128/273 (46%), Positives = 175/273 (64%), Gaps = 2/273 (0%)

Query: 10  LAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKG 69
           L    LG+S++Y D Y  SLL  VPR   R+ L L++  LPFHG+DIW  YELSWLN KG
Sbjct: 4   LKETPLGRSSEYVDQYMPSLLCPVPRWDAREGLELESATLPFHGSDIWNAYELSWLNEKG 63

Query: 70  LPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISV 129
            P VA+  + +  T+ N++ESKS KLYLNSF  TRF + D VR  +E+D++  A G I V
Sbjct: 64  KPIVAMCELRVPCTTPNIVESKSLKLYLNSFANTRFQSRDAVRAAIEKDVAQTAGGNIEV 123

Query: 130 ALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSN 189
            L+ L E  G P+    G C+D+ D+  ++YE+  D L      E+  +  L SHLL+S+
Sbjct: 124 LLFSLQESAGFPVWEDRGDCVDNIDLNFEHYEYRPDLLLCDQGPEQTGQ--LYSHLLRSH 181

Query: 190 CLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKL 249
           C +T QPDW ++ ++Y GR I     LRY+VS R+H  FHEQ +E++F DL+  C P  L
Sbjct: 182 CPVTDQPDWATVVVRYTGRAISPASFLRYVVSLRNHQGFHEQIIEQMFVDLMTQCSPRHL 241

Query: 250 SVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           +VY R+TRRGG+DINP+RSNS+      R +RQ
Sbjct: 242 TVYGRFTRRGGIDINPFRSNSEQPLPNRRTIRQ 274


>UniRef50_Q5P6G9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=1
           Tax=Aromatoleum aromaticum EbN1 RepID=QUEF_AZOSE
          Length = 283

 Score =  398 bits (1024), Expect = e-110,   Method: Composition-based stats.
 Identities = 147/282 (52%), Positives = 180/282 (63%), Gaps = 3/282 (1%)

Query: 2   SSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYE 61
           S   +H A A   LG+S  YRD+Y   LL  + R + RD LGL  D LPF G D+W  YE
Sbjct: 4   SDTHDHGAEAS-PLGQSVVYRDSYAPELLFPIARQIKRDELGLAPDTLPFVGEDLWNAYE 62

Query: 62  LSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLST 121
           LSWLN++G P  A+G   +  TS  LIESKS KLYLNSFNQ RF +   V  TL RDLST
Sbjct: 63  LSWLNSRGKPVAAIGTFRVPVTSPRLIESKSLKLYLNSFNQHRFVDPTLVHDTLTRDLST 122

Query: 122 CAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETL 181
            A   ++V++  L     +  G+ +G  +D+ DI ID Y     +L+ +      V ETL
Sbjct: 123 AAGAPVAVSIEVLSRRPTRVFGYPHGVLLDEIDIEIDTYRTDPAFLQ-SDFNADEVSETL 181

Query: 182 VSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLL 241
            SHLLKSNCL+T QPDWG++ ++Y G  IDR  LLRY+VSFR HNEFHEQCVERIF D+L
Sbjct: 182 YSHLLKSNCLVTGQPDWGTIVLRYIGPPIDRAGLLRYIVSFRSHNEFHEQCVERIFCDVL 241

Query: 242 RFCQPEKLSVYARYTRRGGLDINPWRSNSDFV-PSTTRLVRQ 282
           R C P  L+V+ARYTRRGGLDINP+RS   F        VRQ
Sbjct: 242 RRCAPRHLAVWARYTRRGGLDINPFRSTGHFTQFDNIAEVRQ 283


>UniRef50_Q6ARX8 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2
           Tax=Proteobacteria RepID=QUEF_DESPS
          Length = 276

 Score =  398 bits (1024), Expect = e-110,   Method: Composition-based stats.
 Identities = 134/274 (48%), Positives = 174/274 (63%), Gaps = 6/274 (2%)

Query: 11  AGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGL 70
           AG+ LGK   + +TYD S L  V R   R  LGL AD+LPF G DIW  YELSWL++KG 
Sbjct: 7   AGIPLGKQVGHSETYDPSHLFPVARREARKSLGL-ADDLPFSGPDIWNAYELSWLDSKGK 65

Query: 71  PQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVA 130
           P VA+G +    TS N+IESKS KLYLNSFN TRF +   V++ +  DLS  A  ++ V 
Sbjct: 66  PCVALGEITFPCTSENIIESKSLKLYLNSFNLTRFTSTARVKEIIREDLSRVAGAEVEVK 125

Query: 131 LYRLDELEGQPIGHFNGTCIDDQDI--TIDNYEFTTDYLENATCGEKVVEETLVSHLLKS 188
           +   +E     I    G+CIDD ++   I+ Y  T +YL     G +  EE L ++LL++
Sbjct: 126 ILTPEEFTEVTISAPEGSCIDDLELEEEINAYRPTANYLST---GPEETEEELYTNLLRT 182

Query: 189 NCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEK 248
           NC +T QPDW ++ I YRG+ ID+  LLRY++SFR H  FHE CVERIF D+L  C P +
Sbjct: 183 NCPVTGQPDWATVIINYRGKAIDQRGLLRYIISFRQHEGFHENCVERIFMDILNRCAPAR 242

Query: 249 LSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           L+VYAR+TRRGGLDINP+R+         RL RQ
Sbjct: 243 LTVYARFTRRGGLDINPYRTTHAEHFVNLRLARQ 276


>UniRef50_Q1LSV9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2
           Tax=Gammaproteobacteria RepID=QUEF_BAUCH
          Length = 283

 Score =  388 bits (997), Expect = e-106,   Method: Composition-based stats.
 Identities = 153/280 (54%), Positives = 195/280 (69%), Gaps = 4/280 (1%)

Query: 6   NHQALAGLTLGKS-TDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSW 64
            +Q L    L KS   YR  Y+  LLQ +PR+++R+ LG+ + +LPF G D WTLYELSW
Sbjct: 5   QYQLLQKFKLDKSKISYRTHYNPMLLQPIPRTIHRELLGISSISLPFQGADFWTLYELSW 64

Query: 65  LNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQ 124
           LN  GLPQVA+G + +D TS NLIES+S KLYLNS NQT F++  E+R TL  D++ C  
Sbjct: 65  LNKYGLPQVAIGEMIIDATSDNLIESQSLKLYLNSINQTCFSSEQELRNTLITDITKCIN 124

Query: 125 GKISVALYRLDELEGQPIGHFNGTCIDDQDITI--DNYEFTTDYLENATCGEKVVEETLV 182
            ++ + ++ L +    PI  F G CID+Q I I  DNY F ++ L N+   EK V+ETLV
Sbjct: 125 SQVKITIHSLSQWMTVPILEFTGECIDNQSIQIDNDNYIFNSNLLVNSVEREK-VKETLV 183

Query: 183 SHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLR 242
           SHLLKSNC IT+QPDWGS+QI Y G +I+RE LLRYL+SFR +  FHEQCVE+I+ D+++
Sbjct: 184 SHLLKSNCPITNQPDWGSVQISYYGMRINREALLRYLISFRKYKIFHEQCVEQIYCDIMQ 243

Query: 243 FCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           FC P  LSVY RY RRGGLDINPWRSN  + P    L RQ
Sbjct: 244 FCLPNTLSVYVRYNRRGGLDINPWRSNISYSPVNRPLARQ 283


>UniRef50_Q5X7D5 NADPH-dependent 7-cyano-7-deazaguanine reductase n=43 Tax=Bacteria
           RepID=QUEF_LEGPA
          Length = 285

 Score =  388 bits (997), Expect = e-106,   Method: Composition-based stats.
 Identities = 134/271 (49%), Positives = 180/271 (66%), Gaps = 6/271 (2%)

Query: 15  LGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVA 74
           LG++ +Y   Y+   L  +PR+  R  + L  ++  F+G D W  YE+SWLN+KG P VA
Sbjct: 18  LGQTANYDSYYNPKRLYPIPRAPKRQEINLDPNSTTFYGFDCWNHYEVSWLNSKGKPVVA 77

Query: 75  VGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRL 134
           +  +  D  S  +IESKS KLY NS N + F + + V QT+ +DLS C   +++V +Y L
Sbjct: 78  MAVISYDCHSPCIIESKSLKLYFNSLNNSTFPDVETVVQTISKDLSHCIGSEVAVNVYPL 137

Query: 135 DELEGQPI-GHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLIT 193
            E+  Q I   F+G C+D  DI    Y    D+L  ++   K+VEE L S LLKSNCL+T
Sbjct: 138 SEIASQTIYAAFDGICLDKLDIECSVYHVMPDFLSTSS---KLVEEVLYSDLLKSNCLVT 194

Query: 194 HQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYA 253
           +QPDWGS+QI Y+G++I+ E LL+YL+SFR+HNEFHEQC+ERIF D++RFCQPE L+VY 
Sbjct: 195 NQPDWGSVQIIYKGKKINHEGLLKYLISFRNHNEFHEQCIERIFADIMRFCQPESLAVYG 254

Query: 254 RYTRRGGLDINPWRSNS--DFVPSTTRLVRQ 282
           RYTRRGGLDINP RS     F     RL+RQ
Sbjct: 255 RYTRRGGLDINPIRSTEPCAFDGQNIRLIRQ 285


>UniRef50_Q21VW6 NADPH-dependent 7-cyano-7-deazaguanine reductase n=143
           Tax=Proteobacteria RepID=QUEF_RHOFD
          Length = 289

 Score =  386 bits (993), Expect = e-106,   Method: Composition-based stats.
 Identities = 140/287 (48%), Positives = 175/287 (60%), Gaps = 17/287 (5%)

Query: 11  AGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGL 70
               LG++T Y D YDASLL  + R+  R  +G+    LPF G D+WT +ELSWLN +G 
Sbjct: 5   QNSPLGQATAYLDQYDASLLFPIARATKRAEIGVTG-ALPFLGADMWTAFELSWLNLRGK 63

Query: 71  PQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTC-------- 122
           PQVA+    +   S N+IESKSFKLYLNSFN TRF + D V+  L  DLS          
Sbjct: 64  PQVALARFTVPCESPNIIESKSFKLYLNSFNNTRFADVDAVKARLRADLSEAVWRDAGKN 123

Query: 123 ------AQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKV 176
                 A   I V L   +  + +PI   +G  +D  D+   +Y    D L      E  
Sbjct: 124 VSPDAAAPPSIGVTLLLPELFDREPIYELDGLSLDRLDVECTHYTPAPDLL-RVVPDEAP 182

Query: 177 VEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERI 236
           V E LVS+LLKSNC +T QPDW S+QI Y G  ID+E LL+YLVSFR+HNEFHEQCVERI
Sbjct: 183 VSEVLVSNLLKSNCPVTGQPDWASVQISYSGAPIDQEGLLQYLVSFRNHNEFHEQCVERI 242

Query: 237 FNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDF-VPSTTRLVRQ 282
           F DL   C+P +L+VYARYTRRGGLDINP+R++    +P+  R  RQ
Sbjct: 243 FMDLWTRCKPVRLAVYARYTRRGGLDINPFRTSYAQALPANVRNARQ 289


>UniRef50_Q6FA61 NADPH-dependent 7-cyano-7-deazaguanine reductase n=16
           Tax=Acinetobacter RepID=QUEF_ACIAD
          Length = 271

 Score =  372 bits (955), Expect = e-102,   Method: Composition-based stats.
 Identities = 120/277 (43%), Positives = 165/277 (59%), Gaps = 8/277 (2%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLG-LKADNLPFHGTDIWTLYELSWLN 66
            ++    LGK T+Y  TY  S+L  + R   R+    ++  +    G D W ++ELSWLN
Sbjct: 1   MSVEQSLLGKETEYPTTYSPSVLFPISRDAAREKYAQIEGIS---QGKDWWHVFELSWLN 57

Query: 67  AKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGK 126
           +  +PQVA+G + L  TS  LIESKS KLY NS N   F +  E+   +E+DLS  A  K
Sbjct: 58  SDNIPQVAIGRITLPATSPYLIESKSLKLYFNSLNFHVFASKQELIDLVEKDLSQAANAK 117

Query: 127 ISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLL 186
           +S+ L+ +D LE   I   +G CIDD              L+     +   + TL SHLL
Sbjct: 118 VSLELFDVDSLE---ISKPSGMCIDDLKPERLESHPDASLLKLDANEQHDADVTLYSHLL 174

Query: 187 KSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQP 246
           +SNC +T QPDWG++ I+Y GR+     +L Y++S+R HN FHEQCVE+I+ D+ +  QP
Sbjct: 175 RSNCPVTGQPDWGTVFIRYTGRKHCYRSILAYIISYRQHNGFHEQCVEQIYADIWKNLQP 234

Query: 247 EKLSVYARYTRRGGLDINPWR-SNSDFVPSTTRLVRQ 282
           EKL VYA YTRRGGLDINP R S+  ++P+  RL RQ
Sbjct: 235 EKLMVYATYTRRGGLDINPCRVSDLSWMPNPIRLARQ 271


>UniRef50_A8F0H9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=14
           Tax=Rickettsia RepID=QUEF_RICM5
          Length = 273

 Score =  370 bits (949), Expect = e-101,   Method: Composition-based stats.
 Identities = 121/277 (43%), Positives = 173/277 (62%), Gaps = 6/277 (2%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNA 67
             L+   LGK + Y+D+YD +LL  +PR  NR+ LG+ ++NLPF+G D+W  YELS LN 
Sbjct: 1   MPLSTSLLGKKSTYKDSYDVTLLFKIPRINNRNELGINSNNLPFYGVDVWNTYELSCLNK 60

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKI 127
            G P V VG   +   S N++ESKSFKLYLNSFN     +  E+ + + +DLS     K+
Sbjct: 61  NGKPWVGVGTFYIPTDSENIVESKSFKLYLNSFNNFVVESVKELERIILQDLSNVTHAKV 120

Query: 128 SVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLK 187
           +  ++ ++       G  +G  IDD DI  +NY    + L      + +VEE + S+LLK
Sbjct: 121 TGRIFPIN--TKVEFGVPSGKNIDDLDIVCNNYGAPDNSL--IEYEDVLVEEEINSNLLK 176

Query: 188 SNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           SNCL+T QPDWG++ I+Y+G+++  +  L+YL+SFR+ NEF EQC ERIF D+     P+
Sbjct: 177 SNCLVTGQPDWGTIVIKYKGKKLKHDSFLKYLISFRNCNEFAEQCAERIFTDIKNAISPD 236

Query: 248 KLSVYARYTRRGGLDINPWRSN--SDFVPSTTRLVRQ 282
            LS+   YTRRGG+DI P+RS   S  +PS  R +RQ
Sbjct: 237 FLSISIVYTRRGGIDICPYRSTDKSYTLPSDKRFIRQ 273


>UniRef50_A4A3I6 GTP cyclohydrolase I n=1 Tax=Congregibacter litoralis KT71
           RepID=A4A3I6_9GAMM
          Length = 272

 Score =  369 bits (948), Expect = e-101,   Method: Composition-based stats.
 Identities = 118/272 (43%), Positives = 158/272 (58%), Gaps = 9/272 (3%)

Query: 11  AGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGL 70
            G  LG+     + YD SLL  VPRS  R    L        G DIW  YELSWL+A G+
Sbjct: 10  KGPLLGQQVVGSEQYDPSLLFPVPRSNARA--SLPEQRFQGFGEDIWHAYELSWLSAAGM 67

Query: 71  PQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVA 130
           PQ  VG   +  TS NLIESKS KLYLNS N  RF + +  RQT+ RDLS  A   +S+ 
Sbjct: 68  PQAFVGTFAIPATSANLIESKSLKLYLNSLNNHRFTSAEAARQTIVRDLSEVAGAPVSLT 127

Query: 131 LYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNC 190
           L   ++   +      G+C+DD ++T+   +     L     G+ +    L +HL++S C
Sbjct: 128 LGSPEDPAFRG-EDLPGSCLDDLEVTVP--DAADPVLLTGVAGDGL----LYTHLMRSLC 180

Query: 191 LITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLS 250
            +T QPDW ++ ++ RG   +   LLRYL+++R+H EFHEQCVERI+ D+L   QP+ LS
Sbjct: 181 PVTAQPDWATVVVETRGVAPESPGLLRYLLAYRNHQEFHEQCVERIYTDILDRLQPDYLS 240

Query: 251 VYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           V+A YTRRGGLDI+PWR +        RL RQ
Sbjct: 241 VHALYTRRGGLDISPWRCSEHQPAPRYRLNRQ 272


>UniRef50_B8KG68 NADPH-dependent 7-cyano-7-deazaguanine reductase (Nadph-dependent
           nitrile oxidoreductase) n=1 Tax=gamma proteobacterium
           NOR5-3 RepID=B8KG68_9GAMM
          Length = 276

 Score =  368 bits (945), Expect = e-100,   Method: Composition-based stats.
 Identities = 112/272 (41%), Positives = 152/272 (55%), Gaps = 9/272 (3%)

Query: 11  AGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGL 70
            G  LG+       YD  LL  VPR+  R    L        G DIW  YELSWLNA G+
Sbjct: 14  KGPLLGRQVAGSHYYDPGLLFPVPRANARK--SLPGGAFAGFGEDIWHAYELSWLNASGM 71

Query: 71  PQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVA 130
           PQ+ +G   +   S N+IESKSFKLYLNS N   F +    R+T+ RDLS  A  ++S+ 
Sbjct: 72  PQMFLGTFSVPADSANIIESKSFKLYLNSLNNFEFASDGLARETIVRDLSAVAGAQVSLV 131

Query: 131 LYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNC 190
           L  +D+          G C+D   +++   E   + LE      +V      +HL++S C
Sbjct: 132 LKAVDDQRYDG-RVLEGDCLDGFQVSVPE-EPHVELLEPVVGDARV-----YTHLMRSLC 184

Query: 191 LITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLS 250
            +T QPDW ++ I+ RG    R+KLL YL+++R+H EFHEQCVER++ DL +  +P+ LS
Sbjct: 185 PVTAQPDWATMIIETRGTSAQRDKLLSYLLAYRNHQEFHEQCVERVYTDLWKRLEPDYLS 244

Query: 251 VYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           V A YTRRGGLDI PWR +        R+ RQ
Sbjct: 245 VQALYTRRGGLDICPWRCSEARPAPQGRMNRQ 276


>UniRef50_C8PYF2 Queuine synthase n=3 Tax=Moraxellaceae RepID=C8PYF2_9GAMM
          Length = 283

 Score =  365 bits (938), Expect = e-100,   Method: Composition-based stats.
 Identities = 118/275 (42%), Positives = 165/275 (60%), Gaps = 8/275 (2%)

Query: 15  LGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVA 74
           LG+ST Y  TY   +L  +PR+L R  L L AD L   G D W ++E+SWLN+ G+ QVA
Sbjct: 10  LGQSTSYPKTYAPDMLYPIPRALGRAKLALPADALSI-GMDWWQVFEMSWLNSHGISQVA 68

Query: 75  VGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRL 134
           +  + +  TS  ++ESKS KLY NS N T F+N   V+  +E+DLS C +  +++ ++ +
Sbjct: 69  MVRLAIPATSDYIVESKSLKLYFNSLNFTEFDNQQAVKAAVEKDLSACLKTDVTLEIFEV 128

Query: 135 DELEGQPIGHFNGTCIDDQ------DITIDNYEFTTDYLENATCGEKVVEETLVSHLLKS 188
           +     PI    G CID+        I I +   ++              + L SHLL+S
Sbjct: 129 NIANSLPISAPQGDCIDNALDNSGKKIAIVSDVDSSSLTVADQGASDSQLQILHSHLLRS 188

Query: 189 NCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEK 248
           NC +T+QPDWG+L+IQ   + IDR  LL Y++SFR HN FHEQCVE+IF+DL +   P+ 
Sbjct: 189 NCPVTNQPDWGTLEIQIDSQPIDRAGLLEYILSFRQHNGFHEQCVEQIFSDLTQAFAPKT 248

Query: 249 LSVYARYTRRGGLDINPWR-SNSDFVPSTTRLVRQ 282
           L V A YTRRGG+DINP R S+   +P  +RL RQ
Sbjct: 249 LMVRAWYTRRGGIDINPCRVSDISLLPPPSRLNRQ 283


>UniRef50_Q1QDK8 NADPH-dependent 7-cyano-7-deazaguanine reductase n=3
           Tax=Psychrobacter RepID=QUEF_PSYCK
          Length = 285

 Score =  360 bits (924), Expect = 3e-98,   Method: Composition-based stats.
 Identities = 115/286 (40%), Positives = 167/286 (58%), Gaps = 12/286 (4%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNA 67
            ++ G+   ++TDY   Y    L  + RS+ R+ +G + D L   G D W  +ELSWLN 
Sbjct: 1   MSIHGILGEQTTDYPTEYSPETLYPIARSMGREVIGWQDDKLE-VGFDWWQAFELSWLNE 59

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKI 127
           +G+ QVA+    +  +S  ++ESKS KLYLNS N T F + + V+  + +DLS C Q ++
Sbjct: 60  QGISQVAIARFGIPASSPFIVESKSLKLYLNSINFTEFGSLETVQTLIAKDLSKCVQAEV 119

Query: 128 SVALYRL-DELEGQPIGHFNGTCIDDQ-----DITIDNYEFTTDYLENATCGEKVVEET- 180
           +V L+ L DE  G  I   +G CIDD      +            LE  T   K+ E   
Sbjct: 120 NVELFDLEDEHSGLLIAQPDGICIDDALADSTEKVALTLHPDASLLERNTSDAKISEGKT 179

Query: 181 --LVSHLLKSNCLITHQPDWGSLQIQY-RGRQIDREKLLRYLVSFRHHNEFHEQCVERIF 237
               S+LL+SNC +T+QPDWG+L +     + ++   +LRY++SFR HN FHEQCVE+IF
Sbjct: 180 FSFYSNLLRSNCPVTNQPDWGTLAVSITSNKPVNNANMLRYILSFRQHNGFHEQCVEQIF 239

Query: 238 NDLLRFCQPEKLSVYARYTRRGGLDINPWR-SNSDFVPSTTRLVRQ 282
            DL ++ +P +L V A YTRRGG+DINP R S+   +P  +RL+RQ
Sbjct: 240 ADLSQYYEPSELMVRAWYTRRGGIDINPCRVSDIALLPVPSRLIRQ 285


>UniRef50_B8KRQ4 NADPH-dependent 7-cyano-7-deazaguanine reductase n=1 Tax=gamma
           proteobacterium NOR51-B RepID=B8KRQ4_9GAMM
          Length = 267

 Score =  351 bits (900), Expect = 2e-95,   Method: Composition-based stats.
 Identities = 102/269 (37%), Positives = 139/269 (51%), Gaps = 8/269 (2%)

Query: 15  LGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVA 74
           LG   D    Y   +L+ V R    + L       P  G D+W LYELSWL+ +G P   
Sbjct: 6   LGSRVDAPTRYSPEILEPVERQRGDERLS------PMLGADVWHLYELSWLSREGWPTAF 59

Query: 75  VGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRL 134
           VG + +  +S   +ESKS KLYLNS N  RF+N      T+ RD+       + + +   
Sbjct: 60  VGALAIPASSPRTVESKSLKLYLNSLNFHRFDNERAAVSTIMRDVQAVVGASVDLTIAAP 119

Query: 135 DELEGQPIGHFNGTCIDDQ-DITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLIT 193
            EL  Q      G CIDD     +   ++        + GE  V ETL+SH L+S C +T
Sbjct: 120 TEL-AQWTREPAGVCIDDVFSGALVAADWGASRKTPFSQGEDRVSETLISHQLRSLCPVT 178

Query: 194 HQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYA 253
            QPDWG+L + Y G ++D  +LL ++ SFR H +FHE CVE+I+  L     PE L+V A
Sbjct: 179 GQPDWGTLVVDYSGYRLDPAELLSFVCSFREHQDFHEHCVEQIYKKLFGDLSPEALTVTA 238

Query: 254 RYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
            Y RRGG+DI PWR +        R+ RQ
Sbjct: 239 YYQRRGGIDITPWRGHEKLDAPLWRMGRQ 267


>UniRef50_A0Z1W1 Putative uncharacterized protein n=1 Tax=marine gamma
           proteobacterium HTCC2080 RepID=A0Z1W1_9GAMM
          Length = 267

 Score =  350 bits (899), Expect = 3e-95,   Method: Composition-based stats.
 Identities = 104/273 (38%), Positives = 145/273 (53%), Gaps = 6/273 (2%)

Query: 10  LAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKG 69
           +A   LG+       Y   +L+ + R   R+ LG    ++   G D W LYELSWLN + 
Sbjct: 1   MAVHALGQKVAAPKRYAPDILEAISRREGREALGPAPKSM--VGHDCWHLYELSWLNLRN 58

Query: 70  LPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISV 129
            PQ  VG + +D  S   IESKS KLYLNS N   F +  +  + +  D+    Q  +S+
Sbjct: 59  EPQHCVGVLLVDSASPATIESKSLKLYLNSLNFHCFASEAQACEVICGDIGRVTQSDVSL 118

Query: 130 ALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSN 189
            +   D L G       G  ++      D+    + +      G+ +++ T VSH L+S 
Sbjct: 119 TVLPPDGL-GAITREPEGVLLEADPQQSDHTSMQSPW---CDSGDDILDATYVSHRLRSL 174

Query: 190 CLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKL 249
           C +T QPDWG+L I YRGR I+  +LL ++ SFR H EFHEQCVER F ++++    E L
Sbjct: 175 CPVTAQPDWGTLVIDYRGRPINHHRLLGFIESFREHQEFHEQCVERCFYEVMKQTNAESL 234

Query: 250 SVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
            V A Y RRGG+DI P RSN   VP   R+ RQ
Sbjct: 235 RVSAFYQRRGGIDITPVRSNHRVVPELWRMGRQ 267


>UniRef50_P44165 Uncharacterized protein HI1340 n=9 Tax=Gammaproteobacteria
           RepID=Y1340_HAEIN
          Length = 441

 Score =  336 bits (862), Expect = 5e-91,   Method: Composition-based stats.
 Identities = 127/267 (47%), Positives = 169/267 (63%), Gaps = 18/267 (6%)

Query: 3   SYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFH-GTDIWTLYE 61
           +Y +  +L  L LG+ T+Y   YD +LLQ VPR+LNRD LG+   N PF  G DIWT YE
Sbjct: 2   NYQD-NSLKSLKLGQKTEYASQYDRTLLQPVPRALNRDGLGIT-QNQPFTIGADIWTAYE 59

Query: 62  LSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLST 121
           +SWLN KGLPQVA+  + LDY S NLIESKSFKLYLNSFNQ++F +++ V+QT++RDLS 
Sbjct: 60  ISWLNEKGLPQVAIADIYLDYQSQNLIESKSFKLYLNSFNQSKFTDFNAVQQTMQRDLSE 119

Query: 122 CAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETL 181
           CAQG + V L  +   + Q I H  G CID+QDI I +YEF  ++L++    E +VEE L
Sbjct: 120 CAQGDVKVRLNPVAVYDAQKINHLQGDCIDEQDIEITSYEFNANWLKDCVSNE-IVEEKL 178

Query: 182 VSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIF---- 237
           VSHLLKSNCLIT+QPDWG+ Q Q         KL     +F    +  EQ +  +     
Sbjct: 179 VSHLLKSNCLITNQPDWGTDQAQQAILTARNNKL-----NFETQRKTAEQTLRNLLNLKP 233

Query: 238 NDLLRFCQPEKLSVYARYTRRGGLDIN 264
           N+ L    P  ++V     +  G+++N
Sbjct: 234 NEALNITFPHIMNV-----KTAGVNLN 255


>UniRef50_Q6WI29 GTP cyclohydrolase I family protein n=1 Tax=Vibrio phage KVP40
           RepID=Q6WI29_BPKV4
          Length = 302

 Score =  301 bits (772), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 103/293 (35%), Positives = 143/293 (48%), Gaps = 28/293 (9%)

Query: 1   MSSYANHQALAGLTLGKS-TDYRDTYD-----ASLLQGVPRSLNRDPLGLKADNLPFHGT 54
           MS+Y    A+A   LGK   DY D  D       LL  +PR LNR   G+   N  F G 
Sbjct: 1   MSNYDQVSAIAAEHLGKKAGDYSDFVDIVEVRPDLLVPIPRELNRTDYGIT--NEDFAGF 58

Query: 55  DIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQ-----TRFNNWD 109
           D W  +E+S L  +GLP   +  V     S N++ESKS KLY NSFN      TR    D
Sbjct: 59  DTWHGFEVSALTEQGLPVSGMAKVVYPSDSPNIVESKSMKLYWNSFNMAKVAATRAEVKD 118

Query: 110 EVRQTLERDLSTCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLEN 169
            +     RDLS      + V+ +   E   QP G    T   + D  +     +T +   
Sbjct: 119 AIEAIASRDLSEVIGAPVQVSFFT--EKLTQPHGM---TGFAELDKYVSE---STVFDSE 170

Query: 170 ATCGEKVVEETLVSHL------LKSNCLITHQPDWGSLQIQYRGRQIDR-EKLLRYLVSF 222
           +     +++E+ +  L      L+SNC +THQPD+G L +   G +    + L++Y+VSF
Sbjct: 171 SGADADLLQESHIKKLKVFTPNLRSNCRVTHQPDFGDLYVYMSGEKTPTVDSLMQYIVSF 230

Query: 223 RHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPS 275
           R  N FHE+CVE I+  LL    P +L V A YTRRGG +I P R+  + +  
Sbjct: 231 RKENHFHEECVEMIYKALLDKFDPTELMVTALYTRRGGWNICPARATHEELLP 283


>UniRef50_B7RUV0 GTP cyclohydrolase I subfamily, putative n=1 Tax=marine gamma
           proteobacterium HTCC2148 RepID=B7RUV0_9GAMM
          Length = 168

 Score =  228 bits (582), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 77/172 (44%), Positives = 111/172 (64%), Gaps = 4/172 (2%)

Query: 111 VRQTLERDLSTCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENA 170
           +R+TL++D+       I + L  +D +E    G  +G CIDD  I+ID+     + L+  
Sbjct: 1   MRETLKKDIENTVGASIELELLPVDAVELDG-GIPDGLCIDDLQISIDSSPPGVNLLQ-- 57

Query: 171 TCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHE 230
             GE++VEE + SHLL+S C +T QPDW ++ ++YRGR +  E LLRYL++FR H EFHE
Sbjct: 58  -AGEELVEEAVYSHLLRSLCPVTGQPDWATVYVRYRGRALTHESLLRYLIAFRKHQEFHE 116

Query: 231 QCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           QCVER++ D+ +   PE L + A YTRRGGLDINP+RS+       +R+ RQ
Sbjct: 117 QCVERMYCDIHKLVSPEFLEIQAFYTRRGGLDINPFRSSDANPIPLSRMNRQ 168


>UniRef50_A9VKS1 NADPH-dependent 7-cyano-7-deazaguanine reductase n=310 Tax=Bacteria
           RepID=QUEF_BACWK
          Length = 165

 Score =  157 bits (398), Expect = 3e-37,   Method: Composition-based stats.
 Identities = 35/111 (31%), Positives = 58/111 (52%), Gaps = 4/111 (3%)

Query: 160 YEFTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKL 215
           +E++ + LE        +            S C  T QPD+ ++ I Y    R ++ + L
Sbjct: 24  FEYSPEILEVFDNNHPNRDYFVKFNCPEFTSLCPKTGQPDFATIYISYIPEQRMVESKSL 83

Query: 216 LRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW 266
             YL SFR+H +FHE C+  I NDL++   P  + V+ ++T RGG+ I+P+
Sbjct: 84  KLYLFSFRNHGDFHEDCMNVIMNDLIKLMDPRYIEVWGKFTPRGGISIDPY 134


>UniRef50_Q9ZJJ9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=12
           Tax=Helicobacter RepID=QUEF_HELPJ
          Length = 148

 Score =  154 bits (389), Expect = 4e-36,   Method: Composition-based stats.
 Identities = 38/111 (34%), Positives = 60/111 (54%), Gaps = 4/111 (3%)

Query: 160 YEFTTDYLENATCGEKVVE--ETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKL 215
           +E+ +D LE        ++   TL      S C IT QPD+G + I+Y  +   ++ + L
Sbjct: 18  FEYNSDLLEAFPNPNPNLDPLITLECKEFTSLCPITSQPDFGVIFIRYIPKDKMVESKSL 77

Query: 216 LRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW 266
             YL S+R+H  FHE C+  I  DL++  +P+ L VY  +  RGG+ I P+
Sbjct: 78  KLYLFSYRNHGSFHESCINTILLDLVQLLEPKYLEVYGDFVSRGGIAIKPF 128


>UniRef50_Q6MRJ2 NADPH-dependent 7-cyano-7-deazaguanine reductase n=1
           Tax=Bdellovibrio bacteriovorus RepID=QUEF_BDEBA
          Length = 170

 Score =  149 bits (377), Expect = 8e-35,   Method: Composition-based stats.
 Identities = 36/110 (32%), Positives = 57/110 (51%), Gaps = 4/110 (3%)

Query: 162 FTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLR 217
           +  + LE        K+   T V     S C  T QPD+  + I Y   +  ++ + L  
Sbjct: 28  YAPEVLEAFDNKNPGKIAWTTFVCTEFTSLCPKTRQPDFAKIFINYIADKKMVESKSLKL 87

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWR 267
           YL SFR+H +FHE CV+ I +DL++  +P+ + V   +T RGG+ I P+ 
Sbjct: 88  YLFSFRNHGDFHEDCVQTICDDLVKLMKPKYIEVIGEFTPRGGIAIYPYA 137



 Score = 49.5 bits (117), Expect = 1e-04,   Method: Composition-based stats.
 Identities = 36/119 (30%), Positives = 55/119 (46%), Gaps = 21/119 (17%)

Query: 6   NHQALAGLTLGKS-TDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLY---E 61
           + + LA   LG+S T+Y +TY   +L+      N++P           G   WT +   E
Sbjct: 8   DSKELADFALGESQTNYPETYAPEVLEAF---DNKNP-----------GKIAWTTFVCTE 53

Query: 62  LSWLNAKGLPQVAVGHVELDYTSVN-LIESKSFKLYLNSFNQTRFNNWDEVRQTLERDL 119
            + L  K   Q     + ++Y +   ++ESKS KLYL SF      + D V QT+  DL
Sbjct: 54  FTSLCPKTR-QPDFAKIFINYIADKKMVESKSLKLYLFSFRNHGDFHEDCV-QTICDDL 110


>UniRef50_C4XPJ6 Putative uncharacterized protein n=1 Tax=Desulfovibrio magneticus
           RS-1 RepID=C4XPJ6_DESMR
          Length = 143

 Score =  148 bits (373), Expect = 2e-34,   Method: Composition-based stats.
 Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 4/110 (3%)

Query: 163 TTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRY 218
           T   LE       ++  + T  S    S C  T QPD+G++ I+Y      I+ + L  Y
Sbjct: 28  TPGLLETFPNAFPDRRYDITFASDEFTSLCPKTGQPDFGTITIRYVPDKLCIESKSLKLY 87

Query: 219 LVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRS 268
           L S+R    F E    RI +DL+  CQP  + V   +  RGG+ I+   +
Sbjct: 88  LFSYRDEGAFMETLTNRILDDLVEVCQPHHMEVTGDFAARGGITISVTAT 137


>UniRef50_B3E3W5 7-cyano-7-deazaguanine reductase n=3 Tax=Proteobacteria
           RepID=B3E3W5_GEOLS
          Length = 144

 Score =  145 bits (366), Expect = 1e-33,   Method: Composition-based stats.
 Identities = 36/119 (30%), Positives = 53/119 (44%), Gaps = 2/119 (1%)

Query: 151 DDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--R 208
           D  D  +  +  +                 +        C +T QPD+G++ I Y+   R
Sbjct: 21  DAPDAGLLEWFPSPYVDPELNPCGCTGTLHISCPEFTCLCPMTGQPDFGTIIIDYQPDQR 80

Query: 209 QIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWR 267
            ++ + L  YL SFR H EFHE  V RI NDL++   P  L+V   +T RGG+   P  
Sbjct: 81  CVESKSLKLYLGSFRMHGEFHEAGVNRICNDLVKLLDPVWLTVKGEFTPRGGIPFWPTA 139



 Score = 43.4 bits (101), Expect = 0.008,   Method: Composition-based stats.
 Identities = 36/145 (24%), Positives = 48/145 (33%), Gaps = 15/145 (10%)

Query: 7   HQALAGLTLGKSTDYR-DTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWL 65
           H+ L  L  GK+T Y  D  DA LL+  P       L         H +      E + L
Sbjct: 4   HEGLKTLGEGKATTYSYDAPDAGLLEWFPSPYVDPELNPCGCTGTLHIS----CPEFTCL 59

Query: 66  NA-KGLPQVAVGHVELDYT-SVNLIESKSFKLYLNSFNQT-RFNNWDEVRQTLERDLSTC 122
               G P    G + +DY      +ESKS KLYL SF     F   +     +  DL   
Sbjct: 60  CPMTGQPD--FGTIIIDYQPDQRCVESKSLKLYLGSFRMHGEF--HEAGVNRICNDLVKL 115

Query: 123 AQG---KISVALYRLDELEGQPIGH 144
                  +         +   P   
Sbjct: 116 LDPVWLTVKGEFTPRGGIPFWPTAE 140


>UniRef50_C7JB01 Queuosine biosynthesis protein QueF n=9 Tax=Alphaproteobacteria
           RepID=C7JB01_ACEP3
          Length = 178

 Score =  145 bits (366), Expect = 2e-33,   Method: Composition-based stats.
 Identities = 32/111 (28%), Positives = 49/111 (44%), Gaps = 2/111 (1%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHN 226
            A   +K       +    S C IT QPD+  + I Y   +  ++ + L  YL SFR+H 
Sbjct: 55  PAPYPDKHYLVRFTAPEFTSLCPITGQPDFAHIVIDYVPDKWIVESKSLKLYLTSFRNHG 114

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTT 277
            FHE C  +I N L+    P  L + A +  RGG+ I+ +    +      
Sbjct: 115 AFHEACSIQIANTLVERLAPRWLRIGAYWYPRGGIPIDVFWQTGEPPAGVW 165


>UniRef50_C7M0Q2 7-cyano-7-deazaguanine reductase n=1 Tax=Acidimicrobium
           ferrooxidans DSM 10331 RepID=C7M0Q2_ACIFD
          Length = 155

 Score =  143 bits (362), Expect = 5e-33,   Method: Composition-based stats.
 Identities = 39/127 (30%), Positives = 58/127 (45%), Gaps = 7/127 (5%)

Query: 161 EFTTDYLENATCGEKV--VEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLL 216
           +     LE     +    +   L +    S C +T QPD+G L I Y    R ++ + L 
Sbjct: 21  DPDPSVLETFPTPQPSGGLVIRLFALEFTSLCPVTGQPDYGQLDIVYVPGPRCVESKSLK 80

Query: 217 RYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWR---SNSDFV 273
            YL+ FR+H  FHE CV ++  DL     P  L V  R+  RGG+ I P R   ++ +  
Sbjct: 81  LYLMRFRNHGAFHEACVAQVAQDLASVLAPRYLRVIGRFNARGGIAIWPLREVVADHEDP 140

Query: 274 PSTTRLV 280
            +   LV
Sbjct: 141 AALRALV 147


>UniRef50_D2L9R9 7-cyano-7-deazaguanine reductase n=1 Tax=Desulfovibrio sp. FW1012B
           RepID=D2L9R9_9DELT
          Length = 145

 Score =  141 bits (356), Expect = 3e-32,   Method: Composition-based stats.
 Identities = 35/106 (33%), Positives = 49/106 (46%), Gaps = 4/106 (3%)

Query: 163 TTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRY 218
           T   LE        +    T  S    S C  T QPD+G + I+Y    R I+ + L  Y
Sbjct: 32  TPGLLETFPNAFPGRRYTVTFASEEFTSLCPKTGQPDFGMITIRYVPDERCIESKSLKLY 91

Query: 219 LVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDIN 264
           L S+R    F E    RI +DL+  CQP ++ V   +  RGG+ I+
Sbjct: 92  LFSYRDEGTFMETLTNRILDDLVAACQPLEMEVTGDFAARGGITIS 137



 Score = 46.5 bits (109), Expect = 0.001,   Method: Composition-based stats.
 Identities = 26/121 (21%), Positives = 39/121 (32%), Gaps = 15/121 (12%)

Query: 5   ANHQALAGLTLGK-STDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELS 63
            +   L    LG+ +T Y  T    LL+  P +       +   +  F           S
Sbjct: 12  DDVSTLTT--LGQGATAYPRTVTPGLLETFPNAFPGRRYTVTFASEEFT----------S 59

Query: 64  WLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCA 123
                G P   +  +         IESKS KLYL S+        + +   +  DL    
Sbjct: 60  LCPKTGQPDFGMITIRYVPD-ERCIESKSLKLYLFSYRD-EGTFMETLTNRILDDLVAAC 117

Query: 124 Q 124
           Q
Sbjct: 118 Q 118


>UniRef50_Q8DNP8 NADPH-dependent 7-cyano-7-deazaguanine reductase n=26
           Tax=Streptococcus pneumoniae RepID=QUEF_STRR6
          Length = 154

 Score =  140 bits (352), Expect = 7e-32,   Method: Composition-based stats.
 Identities = 36/105 (34%), Positives = 58/105 (55%), Gaps = 4/105 (3%)

Query: 166 YLENATCGEKVVEETLVSHLLKSNCL--ITHQPDWGSLQIQYRGR--QIDREKLLRYLVS 221
           +LE     E   E+ +  H+L  + L  IT QPD+ ++ I Y      ++ + L  YL S
Sbjct: 19  HLEIQITREIAKEQGIRHHILDMSLLGQITAQPDFATIHISYIPDKLCVESKSLKLYLFS 78

Query: 222 FRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW 266
           +R+H +FHE C+  I  DL+    P  L V+ ++T RGG+ I+P+
Sbjct: 79  YRNHGDFHENCINTIGKDLVNLLDPRYLEVWGKFTPRGGISIDPY 123


>UniRef50_Q8GJN6 NADPH-dependent 7-cyano-7-deazaguanine reductase n=98 Tax=cellular
           organisms RepID=QUEF_SYNE7
          Length = 174

 Score =  140 bits (352), Expect = 8e-32,   Method: Composition-based stats.
 Identities = 34/124 (27%), Positives = 48/124 (38%), Gaps = 13/124 (10%)

Query: 156 TIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDRE 213
           T DN      YL      E             S C +T QPD+  L + Y   Q  ++ +
Sbjct: 49  TFDNPHPDRQYLVRFVAPE-----------FTSLCPLTGQPDFAHLVLDYVPDQRLVESK 97

Query: 214 KLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFV 273
            L  +L SFR+H  FHE C   I   L     P  L +   +  RGGL I+ +  + +  
Sbjct: 98  SLKLFLGSFRNHGAFHENCTLTIAKRLEEAMNPTWLRLGGYWYPRGGLPIDVFYQSGEPP 157

Query: 274 PSTT 277
               
Sbjct: 158 AGVW 161


>UniRef50_Q2IH01 NADPH-dependent 7-cyano-7-deazaguanine reductase n=5 Tax=Bacteria
           RepID=QUEF_ANADE
          Length = 122

 Score =  140 bits (352), Expect = 8e-32,   Method: Composition-based stats.
 Identities = 26/108 (24%), Positives = 45/108 (41%), Gaps = 2/108 (1%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHN 226
                 +  E  +        C +T QPD+ +++++Y    R ++ + L  YL SFR   
Sbjct: 13  PNPKPGRPFEIAMECPEFTCVCPMTGQPDFATIRLRYVPAERCVELKSLKLYLWSFRDEG 72

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVP 274
            FHE    RI +DL+    P  + V   +  RGG+       + +   
Sbjct: 73  TFHEAVTNRICDDLVAALAPRWIEVVGDFAVRGGIHTVVTARHGERPA 120


>UniRef50_A6C8E2 Putative uncharacterized protein n=2 Tax=Planctomycetaceae
           RepID=A6C8E2_9PLAN
          Length = 121

 Score =  139 bits (351), Expect = 9e-32,   Method: Composition-based stats.
 Identities = 34/124 (27%), Positives = 53/124 (42%), Gaps = 13/124 (10%)

Query: 152 DQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQI- 210
           +   T +N     DY+    C E             S C  T QPD+G+L I Y   ++ 
Sbjct: 9   ELLETFENPHPHRDYVMETVCPE-----------FTSVCPKTGQPDYGTLIITYIPDKVC 57

Query: 211 -DREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSN 269
            + + L  YL S+R+   F+E    RI +DL+    P  + + A +T RGG+      S+
Sbjct: 58  FELKSLKMYLQSYRNVGAFYEDVTNRILDDLVAITDPRWMELRAEFTPRGGISSTVTVSH 117

Query: 270 SDFV 273
               
Sbjct: 118 HKED 121


>UniRef50_Q8UD54 NADPH-dependent 7-cyano-7-deazaguanine reductase n=45
           Tax=Alphaproteobacteria RepID=QUEF_AGRT5
          Length = 154

 Score =  139 bits (350), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 34/119 (28%), Positives = 51/119 (42%), Gaps = 13/119 (10%)

Query: 157 IDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREK 214
           + N    TDY+   T  E             S C +T QPD+  + I Y      ++ + 
Sbjct: 30  VPNGNAGTDYVVRFTAPE-----------FTSLCPMTGQPDFAHIVIDYIPGDFLVESKS 78

Query: 215 LLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFV 273
           L  +L SFR+H  FHE C   I   L+   QP+ L + A +  RGG+ I+ +       
Sbjct: 79  LKLFLQSFRNHGAFHEDCSVYIAKRLVELLQPKWLRIGAYWYPRGGIPIDVFWQTGAAP 137


>UniRef50_B2UN89 7-cyano-7-deazaguanine reductase n=2 Tax=Verrucomicrobiaceae
           RepID=B2UN89_AKKM8
          Length = 136

 Score =  137 bits (346), Expect = 3e-31,   Method: Composition-based stats.
 Identities = 36/122 (29%), Positives = 58/122 (47%), Gaps = 6/122 (4%)

Query: 161 EFTTDYLENATC-GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLR 217
                 LE+    G +    TL +H   S C +T QPD   L I Y    + ++ + L  
Sbjct: 18  NPDDARLESFPNRGTRPYTITLDTHEFSSLCPVTGQPDSCHLTITYVPAEKCVETKSLKY 77

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTT 277
           YL ++R++  F+EQ V RI +DL+    P  L V  R++ RGG+ +    + ++  P   
Sbjct: 78  YLAAYRNYPAFNEQIVNRITDDLVAAISPRWLKVEGRFSPRGGIQLT---ATAEHNPENR 134

Query: 278 RL 279
            L
Sbjct: 135 PL 136


>UniRef50_Q3SJI1 NADPH-dependent 7-cyano-7-deazaguanine reductase n=9 Tax=Bacteria
           RepID=QUEF_THIDA
          Length = 139

 Score =  136 bits (344), Expect = 6e-31,   Method: Composition-based stats.
 Identities = 27/116 (23%), Positives = 44/116 (37%), Gaps = 5/116 (4%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRHHN 226
                 +     +        C  T QPD+ +L + Y      ++ + L  Y+ SFR   
Sbjct: 13  PNPKPGRDFHIHMEVPEFTCLCPKTGQPDFATLVLDYIPNQACVELKSLKLYMWSFRDEG 72

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW---RSNSDFVPSTTRL 279
            FHE    RI +DL+    P  + + A++  RGG+  N     R +         L
Sbjct: 73  HFHEDVTNRILDDLVAATDPRYMRLTAKFYVRGGIFTNVVAEHRKDGWQPAPRVDL 128


>UniRef50_Q2LTJ0 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2 Tax=Bacteria
           RepID=QUEF_SYNAS
          Length = 140

 Score =  136 bits (344), Expect = 7e-31,   Method: Composition-based stats.
 Identities = 26/94 (27%), Positives = 41/94 (43%), Gaps = 2/94 (2%)

Query: 173 GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEFHE 230
            ++    T+ +      C +T QPD+  L I Y      ++ + L  YL S+R+   FHE
Sbjct: 34  PDRDYIVTMETAEFTCVCPMTGQPDFADLHISYIPDASILESKSLKLYLWSYRNEGIFHE 93

Query: 231 QCVERIFNDLLRFCQPEKLSVYARYTRRGGLDIN 264
                I  D++    P    V A +  RGG+ I 
Sbjct: 94  HVTNVILEDVVAALSPRWCKVTANFGVRGGISIT 127


>UniRef50_D1N404 7-cyano-7-deazaguanine reductase n=3 Tax=Bacteria
           RepID=D1N404_9BACT
          Length = 142

 Score =  135 bits (339), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 31/98 (31%), Positives = 48/98 (48%), Gaps = 2/98 (2%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRHHN 226
                ++            S C +T QPD+G + ++Y      I+ + L  YL SFR+ N
Sbjct: 35  RNVYADRDYIIEFDCPEYTSLCPVTGQPDFGHIILRYVPDKLCIESKSLKLYLYSFRNTN 94

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDIN 264
            FHE+ V  I + +++ C P K  V  R+  RGG+ IN
Sbjct: 95  TFHEESVNTILDAVVKTCAPRKAEVIGRFRPRGGIAIN 132


>UniRef50_Q0AAV5 NADPH-dependent 7-cyano-7-deazaguanine reductase n=11 Tax=Bacteria
           RepID=QUEF_ALHEH
          Length = 129

 Score =  135 bits (339), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 30/121 (24%), Positives = 45/121 (37%), Gaps = 7/121 (5%)

Query: 167 LENATCGEKVVEETLVS--HLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSF 222
           LE         +  L          C  T QPD+ ++ + Y    R ++ + L  Y+ SF
Sbjct: 9   LETFPNPRPERDFVLHMRIPEFTCLCPKTGQPDFATIHLDYVPDERCVELKSLKLYMWSF 68

Query: 223 RHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW---RSNSDFVPSTTRL 279
           R    FHE     I +DL+R  +P  + V A +  RGG+        R           L
Sbjct: 69  RDQGAFHEAITNEILDDLVRATEPRYMKVTAEFYVRGGIYTTVVAEHRKPGWAPAPKVEL 128

Query: 280 V 280
            
Sbjct: 129 A 129


>UniRef50_C0GIY6 7-cyano-7-deazaguanine reductase n=1 Tax=Dethiobacter alkaliphilus
           AHT 1 RepID=C0GIY6_9FIRM
          Length = 130

 Score =  134 bits (338), Expect = 3e-30,   Method: Composition-based stats.
 Identities = 32/100 (32%), Positives = 43/100 (43%), Gaps = 2/100 (2%)

Query: 167 LENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRH 224
           LE       V    L S  + S C +T QPDW ++ I+Y      I+ + L  Y  SFR 
Sbjct: 19  LEVFEKPAGVDRVVLESDEVTSLCPVTGQPDWETVIIEYEPDRYCIESKSLKLYFWSFRQ 78

Query: 225 HNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDIN 264
              F E    +I ND+   C+P    V      RGG+ I 
Sbjct: 79  EGVFCEGLAAQIANDVHAACKPFFCKVTVIQKPRGGITIT 118


>UniRef50_A8ZUH0 GTP cyclohydrolase I n=2 Tax=Desulfobacteraceae RepID=A8ZUH0_DESOH
          Length = 134

 Score =  132 bits (333), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 30/108 (27%), Positives = 51/108 (47%), Gaps = 2/108 (1%)

Query: 167 LENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRH 224
           +E A    + ++  +      S C +T  PD+G + I+YR R   ++ + L  YL+ +R+
Sbjct: 27  IEYAYRETRPIDVVIRQPEFTSLCPMTGLPDYGCITIRYRPRHHIVELKSLKYYLLQYRN 86

Query: 225 HNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDF 272
              F+E  + RI NDL     P  + V   +T RGG+      +  D 
Sbjct: 87  VGIFYEHVINRILNDLSGAVAPVWMEVSGEFTARGGITTTVTAATGDQ 134


>UniRef50_B3QM19 NADPH-dependent 7-cyano-7-deazaguanine reductase n=4 Tax=Bacteria
           RepID=QUEF_CHLP8
          Length = 116

 Score =  130 bits (328), Expect = 4e-29,   Method: Composition-based stats.
 Identities = 26/96 (27%), Positives = 45/96 (46%), Gaps = 2/96 (2%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRHHN 226
           + T   +     +V+    S C  T  PD+G++ I Y      I+ + L  Y + FR+  
Sbjct: 10  DNTFPNRDYTIEIVNPEFTSVCPKTGLPDFGTITITYVPDKSCIELKSLKYYFLEFRNAG 69

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLD 262
            F+E     I + L+  CQP+ ++V   +  RGG+ 
Sbjct: 70  IFYENITNTILDHLVEACQPKSMTVKTDWNARGGIT 105


>UniRef50_A1WY83 NADPH-dependent 7-cyano-7-deazaguanine reductase n=5 Tax=Bacteria
           RepID=QUEF_HALHL
          Length = 118

 Score =  130 bits (328), Expect = 4e-29,   Method: Composition-based stats.
 Identities = 24/95 (25%), Positives = 41/95 (43%), Gaps = 2/95 (2%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRHHN 226
                E+     +        C  T QPD+ +L ++Y      ++ + L  Y+ S+R   
Sbjct: 13  ENPNPERDYTIRMEIPEFTCLCPKTGQPDFATLNLEYIPERHCVELKSLKLYIWSYRDVG 72

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGL 261
            FHE    +I  DL+   QP  + + A +  RGG+
Sbjct: 73  GFHEALTNQILGDLVAATQPRYMKLTAHFNVRGGI 107


>UniRef50_Q2J7K4 NADPH-dependent 7-cyano-7-deazaguanine reductase n=4
           Tax=Actinomycetales RepID=QUEF_FRASC
          Length = 125

 Score =  130 bits (327), Expect = 6e-29,   Method: Composition-based stats.
 Identities = 36/137 (26%), Positives = 54/137 (39%), Gaps = 24/137 (17%)

Query: 129 VALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKS 188
           +AL +L   E +         IDD    I                       +       
Sbjct: 1   MALTKLGNPEAKADRSLETFPIDDTSQEI----------------------RIDCREFTC 38

Query: 189 NCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQP 246
            C IT QPDW +++I YR   R ++ + L  YL +FR    FHE     I +DL+    P
Sbjct: 39  RCPITGQPDWATIRIDYRPGGRGLETKSLKLYLETFREEGIFHEHLATLIRDDLVAALAP 98

Query: 247 EKLSVYARYTRRGGLDI 263
            +L+V   +  RGG+ +
Sbjct: 99  VQLTVTVNFNARGGIAL 115


>UniRef50_B8DRK9 7-cyano-7-deazaguanine reductase n=2 Tax=Desulfovibrio
           RepID=B8DRK9_DESVM
          Length = 188

 Score =  129 bits (324), Expect = 1e-28,   Method: Composition-based stats.
 Identities = 22/129 (17%), Positives = 46/129 (35%), Gaps = 4/129 (3%)

Query: 153 QDITIDNYEFTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--R 208
                 +       LE       ++    ++      S C +T QPD+ ++  +Y    R
Sbjct: 40  VKAEYPHAGPGPHILEAFPNNFPDRPYIVSIAFPEFTSLCPVTGQPDFATIVTEYIPDQR 99

Query: 209 QIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRS 268
            ++ +    Y+ ++R+H  F E     + + +     P    V   +T RGG  ++ +  
Sbjct: 100 CVESKSFKLYMFAYRNHQSFMETITNTVLDHMTEALDPLWCRVKGLFTPRGGTHLHVFAE 159

Query: 269 NSDFVPSTT 277
               V    
Sbjct: 160 RFKQVEEPR 168


>UniRef50_B3EMR0 NADPH-dependent 7-cyano-7-deazaguanine reductase n=9 Tax=Bacteria
           RepID=QUEF_CHLPB
          Length = 118

 Score =  129 bits (324), Expect = 1e-28,   Method: Composition-based stats.
 Identities = 26/105 (24%), Positives = 47/105 (44%), Gaps = 4/105 (3%)

Query: 162 FTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLR 217
              + LE       ++     +V+    S C IT  PD+G++ I+Y      ++ + L  
Sbjct: 1   MQKELLEVFDNRFPDRDYTIEIVNPEFTSVCPITGLPDFGTITIRYIPDKVCVELKSLKY 60

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLD 262
           Y + FR+   F+E     I + L+   +P  L+V   +  RGG+ 
Sbjct: 61  YYLEFRNAGIFYENVTNTILDHLVDLLKPRTLTVTTAWKARGGIT 105


>UniRef50_C1CXM3 Putative GTP cyclohydrolase I n=2 Tax=Deinococcus deserti VCD115
           RepID=C1CXM3_DEIDV
          Length = 155

 Score =  128 bits (322), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 33/132 (25%), Positives = 59/132 (44%), Gaps = 7/132 (5%)

Query: 150 IDDQDITI-DNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR 208
           +D  D+ + D + +       A  GE +  E +++      C  +  PD+G L+I+Y+ R
Sbjct: 20  LDAIDVAVLDTFAYVRQDDPAAYPGEPMDIE-IITDEFSPVCPWSGLPDFGRLEIRYQPR 78

Query: 209 --QIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW 266
              ++ + L  YL S+R    +HE    R+  DL +   P  +++   Y  RGGL+    
Sbjct: 79  EKCVELKSLKYYLTSYRFVGIYHEHATRRLLADLTQLLDPLSMTIRCDYGMRGGLN---T 135

Query: 267 RSNSDFVPSTTR 278
                +V    R
Sbjct: 136 VCTVRYVAPERR 147


>UniRef50_B5JRC9 7-cyano-7-deazaguanine reductase n=1 Tax=Verrucomicrobiae bacterium
           DG1235 RepID=B5JRC9_9BACT
          Length = 126

 Score =  127 bits (319), Expect = 5e-28,   Method: Composition-based stats.
 Identities = 30/102 (29%), Positives = 49/102 (48%), Gaps = 2/102 (1%)

Query: 165 DYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSF 222
           D L+     E V   T+ S  L S+C IT QPD+ ++ I+Y  +   I+ + L  +L  F
Sbjct: 15  DELDTFEAPEGVTTVTMTSDELTSSCPITGQPDFYNVSIEYAPKELCIESKSLKLFLWGF 74

Query: 223 RHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDIN 264
           R    F E+    I + +++   P +  V      RGG++I 
Sbjct: 75  RDKAMFAEKIAAVICDRVVQDISPRRCRVMTFQKARGGIEIE 116


>UniRef50_B7J648 NADPH-dependent 7-cyano-7-deazaguanine reductase n=22 Tax=Bacteria
           RepID=QUEF_ACIF2
          Length = 141

 Score =  125 bits (313), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 26/94 (27%), Positives = 41/94 (43%), Gaps = 2/94 (2%)

Query: 173 GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEFHE 230
            E+     +        C +T QPD+    + +   Q  ++ + L  YL SFR    FHE
Sbjct: 17  PERDYVVHMDLPEFTCLCPLTGQPDFAHFMLDFIPDQHNVELKSLKLYLWSFRDEGAFHE 76

Query: 231 QCVERIFNDLLRFCQPEKLSVYARYTRRGGLDIN 264
               RI +DL+    P  L +  R+  RGG+  +
Sbjct: 77  AMTNRIADDLIGLINPRYLRLLGRWYVRGGITTD 110


>UniRef50_B8IYG6 NADPH-dependent 7-cyano-7-deazaguanine reductase n=6
           Tax=Desulfovibrionaceae RepID=QUEF_DESDA
          Length = 167

 Score =  124 bits (311), Expect = 4e-27,   Method: Composition-based stats.
 Identities = 28/134 (20%), Positives = 51/134 (38%), Gaps = 6/134 (4%)

Query: 155 ITIDNYEFTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QI 210
           +T      +   LE       ++    ++      S C +T QPD G++ ++Y      +
Sbjct: 20  LTSPEGGPSVALLEAFPNCFPQRPYVISISFPEFTSLCPVTGQPDCGTITVEYIPDELCV 79

Query: 211 DREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNS 270
           + +    Y+ +FR+H  F E     +  DL     P    V   +  RGG  I+ +    
Sbjct: 80  ESKSFKLYMFAFRNHQSFMETITNNVLEDLRALLNPCWCRVKGLFAPRGGTRIHVFAEAF 139

Query: 271 D--FVPSTTRLVRQ 282
                   + LVR+
Sbjct: 140 KDGMPEEQSALVRE 153


>UniRef50_Q04RM8 NADPH-dependent 7-cyano-7-deazaguanine reductase n=6 Tax=Leptospira
           RepID=QUEF_LEPBJ
          Length = 133

 Score =  123 bits (309), Expect = 7e-27,   Method: Composition-based stats.
 Identities = 27/101 (26%), Positives = 41/101 (40%), Gaps = 2/101 (1%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHN 226
                 K            + C  T  PD+G + + Y    R I+ +    Y++S+R+  
Sbjct: 28  TNVYEGKDYTIDFTVPEFTAVCPKTGLPDFGVIYVSYVPTKRCIELKSFKEYILSYRNVG 87

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWR 267
            FHE  V +I  DL+    P+ L V   Y  RGG+     R
Sbjct: 88  VFHEFLVNKIMEDLIAAIDPKYLKVIGDYNARGGIKTVVTR 128


>UniRef50_B2KDU6 NADPH-dependent 7-cyano-7-deazaguanine reductase n=4 Tax=Bacteria
           RepID=QUEF_ELUMP
          Length = 132

 Score =  122 bits (307), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 25/89 (28%), Positives = 43/89 (48%), Gaps = 2/89 (2%)

Query: 175 KVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRHHNEFHEQC 232
           +  +  +      S C  T  PD+G + I Y      ++ + L  YL+ +R    F E  
Sbjct: 33  RDYDIRIELPEFTSVCPKTGLPDFGVITIDYIPDRLCLELKSLKYYLLEYRDMGIFMENI 92

Query: 233 VERIFNDLLRFCQPEKLSVYARYTRRGGL 261
             +I +D+++ C+P+K  V   +T RGGL
Sbjct: 93  ANKILDDVVKACKPKKAVVTGDFTPRGGL 121


>UniRef50_A8W229 ATP-dependent metalloprotease FtsH n=1 Tax=Bacillus
           selenitireducens MLS10 RepID=A8W229_9BACI
          Length = 135

 Score =  121 bits (305), Expect = 2e-26,   Method: Composition-based stats.
 Identities = 27/109 (24%), Positives = 49/109 (44%), Gaps = 3/109 (2%)

Query: 159 NYEFTTDYLENATCGEKVVEET-LVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKL 215
           + E   + L +       V      +    + C  T QPD+G ++I+Y  R   I+ + L
Sbjct: 18  SVEEGRNVLRDEAFPAPDVSVVRFKALEFTAVCPKTGQPDFGQVEIEYVPRNKCIESKSL 77

Query: 216 LRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDIN 264
             YL S+R    + E    +I +D++   +P ++ V    T RGG+ + 
Sbjct: 78  KFYLWSYRDEGAYCESLAAQIADDVMAAIEPARVKVMVHQTPRGGIQLE 126


>UniRef50_B0KAC5 NADPH-dependent 7-cyano-7-deazaguanine reductase n=11
           Tax=Clostridia RepID=QUEF_THEP3
          Length = 133

 Score =  118 bits (296), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 29/115 (25%), Positives = 50/115 (43%), Gaps = 12/115 (10%)

Query: 150 IDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ 209
           ID + +    YE+           EK      +++   S C  T  PD   L I+Y   +
Sbjct: 18  IDKEVLESIEYEY----------PEKNTIVEYITNEFSSVCPWTGLPDNAKLTIRYIPSK 67

Query: 210 --IDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLD 262
             ++ + L  YL S+R+     E  + RI +DL+   QP+ + +   +  RGG+ 
Sbjct: 68  KLVELKSLKYYLTSYRNVGILQEHAINRILDDLVELLQPKFMEIIGEFQERGGIA 122


>UniRef50_A5IIZ4 NADPH-dependent 7-cyano-7-deazaguanine reductase n=7
           Tax=Thermotogaceae RepID=QUEF_THEP1
          Length = 137

 Score =  117 bits (294), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 27/104 (25%), Positives = 48/104 (46%), Gaps = 3/104 (2%)

Query: 164 TDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG---RQIDREKLLRYLV 220
           TD+LE      K     + +    + C  +  PD G + I+Y     + ++ + L  Y V
Sbjct: 19  TDFLEAIDFDGKDEYIKIETDEFSAVCPFSGLPDIGRVIIEYYPDGGKIVELKSLKYYFV 78

Query: 221 SFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDIN 264
           SFR+   + E+  +RI+ DL    + +++ V   Y  RGG+   
Sbjct: 79  SFRNVGIYQEEATKRIYEDLKNLLKTDRIRVTVIYNIRGGIKTT 122


>UniRef50_Q8DMA3 NADPH-dependent 7-cyano-7-deazaguanine reductase n=14 Tax=Bacteria
           RepID=QUEF_THEEB
          Length = 132

 Score = 99.2 bits (246), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 25/111 (22%), Positives = 46/111 (41%), Gaps = 13/111 (11%)

Query: 151 DDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--R 208
           + Q IT  N      Y          +E TL        C  +  PD+ +L + Y    +
Sbjct: 15  EGQLITFPNPRPGRQY---------TIEITL--PEFTCKCPFSGYPDFATLYVSYIPHEK 63

Query: 209 QIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRG 259
            ++ + +  Y+ S+R     HE+ V ++ +DL+  C P  + +   +  RG
Sbjct: 64  VVELKAIKLYINSYRDRYISHEEAVNQVLDDLVAACDPLYMKIKGDFAPRG 114


>UniRef50_B8HRW7 7-cyano-7-deazaguanine reductase n=2 Tax=Cyanobacteria
           RepID=B8HRW7_CYAP4
          Length = 142

 Score = 98.9 bits (245), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 20/89 (22%), Positives = 40/89 (44%), Gaps = 2/89 (2%)

Query: 173 GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEFHE 230
             +     +        C  +  PD+ ++ + Y   Q  ++ + +  Y+ S+R     HE
Sbjct: 41  PGRRYTIQITLPEFTCKCPFSGYPDFATIHVSYIPDQRVVELKAIKLYINSYRDRYISHE 100

Query: 231 QCVERIFNDLLRFCQPEKLSVYARYTRRG 259
           + V +I +DL+  C P ++SV   +  RG
Sbjct: 101 ESVNQILDDLVTACDPLQISVKGDFAPRG 129


>UniRef50_B4U9Q5 7-cyano-7-deazaguanine reductase n=5 Tax=Bacteria
           RepID=B4U9Q5_HYDS0
          Length = 128

 Score = 98.1 bits (243), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 25/110 (22%), Positives = 48/110 (43%), Gaps = 5/110 (4%)

Query: 154 DITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--ID 211
           +I I+       +   A   + ++E +         C  +  PD+ +++I+Y   +  ++
Sbjct: 9   EIEIEKAALEP-WENPAKENDYIIEMSF--PEFSCLCPRSGYPDYATIKIRYIPNEYIVE 65

Query: 212 REKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGL 261
            + L  +L SFR+    HE     I+N L    +P+ L V   +  RG L
Sbjct: 66  LKSLKLWLNSFRNQYISHEAATNTIYNKLFELLKPKFLEVIGDFHPRGNL 115


>UniRef50_A6Q0W4 NADPH-dependent 7-cyano-7-deazaguanine reductase n=6 Tax=Bacteria
           RepID=QUEF_NITSB
          Length = 131

 Score = 98.1 bits (243), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 22/108 (20%), Positives = 44/108 (40%), Gaps = 2/108 (1%)

Query: 154 DITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--ID 211
           +  I  ++   D         K  +  +        C  +  PD+ ++ ++Y   Q  ++
Sbjct: 5   EKEIQEFDPKKDLEIWPNKHNKPYKIKITLPEFSCLCPRSGYPDYATMHLEYIPDQYVVE 64

Query: 212 REKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRG 259
            + L  Y+ SFR+    HE     IF+ L    +P+ + + A +  RG
Sbjct: 65  LKALKLYINSFRNRYISHEDSTNEIFDTLYSKLKPKYMRLVADFNPRG 112


>UniRef50_B5IMF1 7-cyano-7-deazaguanine reductase n=1 Tax=Cyanobium sp. PCC 7001
           RepID=B5IMF1_9CHRO
          Length = 154

 Score = 98.1 bits (243), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 23/100 (23%), Positives = 47/100 (47%), Gaps = 3/100 (3%)

Query: 173 GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHNEFHE 230
             +V E ++        C  +  PD+ +LQ+ Y+   R ++ + +  Y+ S+R     HE
Sbjct: 50  PGRVYEISITLPEFTCLCPFSGYPDFATLQLLYQPGPRVMELKAIKLYVNSYRDRTISHE 109

Query: 231 QCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNS 270
           + V R+ +D +  C P  + + A +  RG +     R++ 
Sbjct: 110 EVVNRLLDDFVAACDPVWMQLEADFNPRGNVH-TVIRASH 148


>UniRef50_B0CDX9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=40
           Tax=Cyanobacteria RepID=QUEF_ACAM1
          Length = 144

 Score = 96.9 bits (240), Expect = 7e-19,   Method: Composition-based stats.
 Identities = 19/87 (21%), Positives = 41/87 (47%), Gaps = 2/87 (2%)

Query: 175 KVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEFHEQC 232
           +  +  +        C  +  PD+ ++ + Y   Q  ++ + L  Y+ S+R     HE+ 
Sbjct: 46  RRYDIHITLPEFTCKCPFSGYPDFATIHLTYVPDQRVVELKALKLYINSYRDRYISHEES 105

Query: 233 VERIFNDLLRFCQPEKLSVYARYTRRG 259
           V +I +D++  C P +++V   +  RG
Sbjct: 106 VNQILDDIVAACDPLEITVKGDFLPRG 132


>UniRef50_B5IBP5 7-cyano-7-deazaguanine reductase n=2 Tax=Aciduliprofundum boonei
           T469 RepID=B5IBP5_9EURY
          Length = 135

 Score = 95.8 bits (237), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 23/99 (23%), Positives = 40/99 (40%), Gaps = 2/99 (2%)

Query: 171 TCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEF 228
              E       +   L + C  T  PD+  L+I Y   +   + + L  YL+++R+   +
Sbjct: 12  EYPETKEVVEYIYPELTAVCPQTGLPDYYILRILYEPDKKLPELKSLKMYLIAYRNFGIW 71

Query: 229 HEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWR 267
           HE    +I +D     +P  + V      RGG+     R
Sbjct: 72  HEHLANKILDDFKSAVEPRWVYVELYVNNRGGIYTTVRR 110


>UniRef50_Q113I7 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2
           Tax=Cyanobacteria RepID=QUEF_TRIEI
          Length = 141

 Score = 93.5 bits (231), Expect = 8e-18,   Method: Composition-based stats.
 Identities = 19/87 (21%), Positives = 40/87 (45%), Gaps = 2/87 (2%)

Query: 175 KVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHNEFHEQC 232
           +  E  +        C  +  PD+ ++ I+Y    R ++ + +  Y+ S+R     HE+ 
Sbjct: 41  RRYEINISLPEFTCKCPFSGYPDFATIHIKYIPNERVVELKAIKLYINSYRERYISHEES 100

Query: 233 VERIFNDLLRFCQPEKLSVYARYTRRG 259
           V +I +D +  C P ++ +   +  RG
Sbjct: 101 VNQILDDFVAACDPLEVKIKGDFLPRG 127


>UniRef50_D0MDN3 7-cyano-7-deazaguanine reductase n=1 Tax=Rhodothermus marinus DSM
           4252 RepID=D0MDN3_RHOM4
          Length = 168

 Score = 92.3 bits (228), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 3/80 (3%)

Query: 185 LLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEFHEQCVERIFNDLLR 242
              + C  +  PD+G L+I+Y      ++ + L  Y+VS+R+     E     I+ DL+R
Sbjct: 76  EFSAVCPFSGLPDYGVLRIEYVPGSWILELKSLKYYIVSWRNIGAAQEDLTAIIYQDLMR 135

Query: 243 FC-QPEKLSVYARYTRRGGL 261
               PE L V   Y  RGG+
Sbjct: 136 HLEDPEYLRVITVYNVRGGI 155


>UniRef50_B7JWF0 7-cyano-7-deazaguanine reductase n=8 Tax=Cyanobacteria
           RepID=B7JWF0_CYAP8
          Length = 142

 Score = 91.5 bits (226), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 16/87 (18%), Positives = 39/87 (44%), Gaps = 2/87 (2%)

Query: 175 KVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEFHEQC 232
           +  +  +        C  +  PD+ +L + Y   +  ++ + L  Y+  +R     HE+ 
Sbjct: 41  RRYDINITLPEFTCKCPFSGYPDFATLYLTYIPDEKVVELKALKLYINRYRDRYISHEES 100

Query: 233 VERIFNDLLRFCQPEKLSVYARYTRRG 259
           + +I +D +  C P ++++   +  RG
Sbjct: 101 INQILDDFVAACDPLEVTLKGDFNPRG 127


>UniRef50_D2REX4 GTP cyclohydrolase I n=1 Tax=Archaeoglobus profundus DSM 5631
           RepID=D2REX4_ARCPR
          Length = 236

 Score = 86.5 bits (213), Expect = 8e-16,   Method: Composition-based stats.
 Identities = 35/182 (19%), Positives = 63/182 (34%), Gaps = 26/182 (14%)

Query: 106 NNWDEVRQTLERDLSTCAQGKISVALY---RLDELEGQPIGHFNGTCIDDQDITIDNYEF 162
           +N +  R+ + RDL  C +  + V +        +    I    G  +           +
Sbjct: 47  DNEELCREIVTRDLELCEKADVIVLVAKHPSFGAMAEVVISAMKGKPVVAFCPEKVRSPW 106

Query: 163 TTDY--------------LENATCGEKVVEETLVSHL-------LKSNCLITHQPDWGSL 201
              +              L+      + +      H            C +T   D G++
Sbjct: 107 PIYFANKVVRSEEELVRALKELETPLRTIPNVYSDHEAEFTYTKFTCICPVTGLRDIGTI 166

Query: 202 QIQYRG--RQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRG 259
           +I+Y+   R ++ E L  Y   F      HE  V ++FND+ +   PE L V A +  R 
Sbjct: 167 KIRYKPKDRILEYESLDSYFKLFADKKMHHEAVVCKVFNDIYQALNPEWLEVVAEFEERS 226

Query: 260 GL 261
           G+
Sbjct: 227 GV 228


>UniRef50_Q5HS73 NADPH-dependent 7-cyano-7-deazaguanine reductase n=20 Tax=Bacteria
           RepID=QUEF_CAMJR
          Length = 127

 Score = 83.4 bits (205), Expect = 7e-15,   Method: Composition-based stats.
 Identities = 22/117 (18%), Positives = 48/117 (41%), Gaps = 4/117 (3%)

Query: 161 EFTTDYLENATCGEK-VVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLR 217
           EF  + +E      K      +        C  +  PD+ ++ ++Y   +  ++ + +  
Sbjct: 10  EFDVENMEIWPNDAKNDYIIKITLPEFMCCCPRSGYPDFATIYLEYMPNKFVVELKAIKL 69

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGL-DINPWRSNSDFV 273
           Y+ +F + N  HE  +  I+N L    +P+ + V   +  RG +  +   RS+    
Sbjct: 70  YINTFMYRNVSHEASINEIYNTLKDKLKPKWIKVVGDFNPRGNVHTVIECRSDMVVP 126


>UniRef50_Q9YBX9 Putative GTP cyclohydrolase I n=1 Tax=Aeropyrum pernix
           RepID=Q9YBX9_AERPE
          Length = 101

 Score = 56.5 bits (135), Expect = 1e-06,   Method: Composition-based stats.
 Identities = 19/66 (28%), Positives = 28/66 (42%), Gaps = 2/66 (3%)

Query: 188 SNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQ 245
           + C  T  PD   ++I+Y  R   ++   L  +L SFR      EQ    I   L    +
Sbjct: 8   AVCPFTGAPDSYDVEIEYVSRDACLEALSLASWLESFRGVKISQEQLAHEIALTLKELLK 67

Query: 246 PEKLSV 251
           PE + V
Sbjct: 68  PEYVCV 73


>UniRef50_A2BLN0 Predicted GTP cyclohydrolase I n=1 Tax=Hyperthermus butylicus DSM
           5456 RepID=A2BLN0_HYPBU
          Length = 119

 Score = 46.9 bits (110), Expect = 8e-04,   Method: Composition-based stats.
 Identities = 16/83 (19%), Positives = 32/83 (38%), Gaps = 7/83 (8%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG-------RQIDREKLLRYLVS 221
               GE  VE+ +++  +++ C +T   D   + ++Y+        R I+      YL S
Sbjct: 7   RVVEGEACVEKVVLTGSVEAVCPVTGMVDLYRVIVEYKPSSAGRVCRYIEALSFHFYLQS 66

Query: 222 FRHHNEFHEQCVERIFNDLLRFC 244
           ++      E+    I  D     
Sbjct: 67  YKGRKILQEELTATIVRDFCEAL 89


>UniRef50_B1SCE4 Putative uncharacterized protein n=1 Tax=Streptococcus infantarius
           subsp. infantarius ATCC BAA-102 RepID=B1SCE4_9STRE
          Length = 58

 Score = 45.7 bits (107), Expect = 0.002,   Method: Composition-based stats.
 Identities = 11/27 (40%), Positives = 18/27 (66%)

Query: 240 LLRFCQPEKLSVYARYTRRGGLDINPW 266
           ++   QP  L V+ ++T RGGL I+P+
Sbjct: 1   MIDLLQPRYLEVWGKFTPRGGLSIDPY 27


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q0T1R0 NADPH-dependent 7-cyano-7-deazaguanine reductase...   433   e-120
UniRef50_Q0HGT5 NADPH-dependent 7-cyano-7-deazaguanine reductase...   398   e-109
UniRef50_Q7WH69 NADPH-dependent 7-cyano-7-deazaguanine reductase...   387   e-106
UniRef50_Q1K442 GTP cyclohydrolase I n=2 Tax=Proteobacteria RepI...   383   e-105
UniRef50_A4VK37 GTP cyclohydrolase I, putative n=2 Tax=Gammaprot...   382   e-105
UniRef50_A4T050 GTP cyclohydrolase I n=2 Tax=Proteobacteria RepI...   380   e-104
UniRef50_Q0VR70 NADPH-dependent 7-cyano-7-deazaguanine reductase...   377   e-103
UniRef50_Q5P6G9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   375   e-103
UniRef50_Q6ARX8 NADPH-dependent 7-cyano-7-deazaguanine reductase...   370   e-101
UniRef50_Q1LSV9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   363   4e-99
UniRef50_Q5X7D5 NADPH-dependent 7-cyano-7-deazaguanine reductase...   360   2e-98
UniRef50_Q21VW6 NADPH-dependent 7-cyano-7-deazaguanine reductase...   359   7e-98
UniRef50_Q6FA61 NADPH-dependent 7-cyano-7-deazaguanine reductase...   357   2e-97
UniRef50_B8KG68 NADPH-dependent 7-cyano-7-deazaguanine reductase...   349   7e-95
UniRef50_C8PYF2 Queuine synthase n=3 Tax=Moraxellaceae RepID=C8P...   348   1e-94
UniRef50_A4A3I6 GTP cyclohydrolase I n=1 Tax=Congregibacter lito...   344   2e-93
UniRef50_A8F0H9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   341   1e-92
UniRef50_Q1QDK8 NADPH-dependent 7-cyano-7-deazaguanine reductase...   340   3e-92
UniRef50_B8KRQ4 NADPH-dependent 7-cyano-7-deazaguanine reductase...   331   2e-89
UniRef50_A0Z1W1 Putative uncharacterized protein n=1 Tax=marine ...   329   8e-89
UniRef50_P44165 Uncharacterized protein HI1340 n=9 Tax=Gammaprot...   298   2e-79
UniRef50_Q6WI29 GTP cyclohydrolase I family protein n=1 Tax=Vibr...   282   9e-75
UniRef50_B7RUV0 GTP cyclohydrolase I subfamily, putative n=1 Tax...   216   7e-55
UniRef50_B8DRK9 7-cyano-7-deazaguanine reductase n=2 Tax=Desulfo...   165   2e-39
UniRef50_A9VKS1 NADPH-dependent 7-cyano-7-deazaguanine reductase...   165   2e-39
UniRef50_Q2IH01 NADPH-dependent 7-cyano-7-deazaguanine reductase...   163   8e-39
UniRef50_B3E3W5 7-cyano-7-deazaguanine reductase n=3 Tax=Proteob...   162   2e-38
UniRef50_C7JB01 Queuosine biosynthesis protein QueF n=9 Tax=Alph...   162   2e-38
UniRef50_Q3SJI1 NADPH-dependent 7-cyano-7-deazaguanine reductase...   159   9e-38
UniRef50_C4XPJ6 Putative uncharacterized protein n=1 Tax=Desulfo...   159   1e-37
UniRef50_Q0AAV5 NADPH-dependent 7-cyano-7-deazaguanine reductase...   158   2e-37
UniRef50_C7M0Q2 7-cyano-7-deazaguanine reductase n=1 Tax=Acidimi...   157   4e-37
UniRef50_B8IYG6 NADPH-dependent 7-cyano-7-deazaguanine reductase...   156   8e-37
UniRef50_Q9ZJJ9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   154   4e-36
UniRef50_D2L9R9 7-cyano-7-deazaguanine reductase n=1 Tax=Desulfo...   153   5e-36
UniRef50_Q8GJN6 NADPH-dependent 7-cyano-7-deazaguanine reductase...   153   5e-36
UniRef50_Q8UD54 NADPH-dependent 7-cyano-7-deazaguanine reductase...   153   6e-36
UniRef50_Q6MRJ2 NADPH-dependent 7-cyano-7-deazaguanine reductase...   152   2e-35
UniRef50_A6C8E2 Putative uncharacterized protein n=2 Tax=Plancto...   152   2e-35
UniRef50_A1WY83 NADPH-dependent 7-cyano-7-deazaguanine reductase...   151   2e-35
UniRef50_Q2LTJ0 NADPH-dependent 7-cyano-7-deazaguanine reductase...   149   1e-34
UniRef50_D1N404 7-cyano-7-deazaguanine reductase n=3 Tax=Bacteri...   146   7e-34
UniRef50_B2UN89 7-cyano-7-deazaguanine reductase n=2 Tax=Verruco...   146   7e-34
UniRef50_B3QM19 NADPH-dependent 7-cyano-7-deazaguanine reductase...   144   4e-33
UniRef50_A8ZUH0 GTP cyclohydrolase I n=2 Tax=Desulfobacteraceae ...   142   1e-32
UniRef50_D2REX4 GTP cyclohydrolase I n=1 Tax=Archaeoglobus profu...   142   1e-32
UniRef50_B3EMR0 NADPH-dependent 7-cyano-7-deazaguanine reductase...   142   2e-32
UniRef50_B7J648 NADPH-dependent 7-cyano-7-deazaguanine reductase...   142   2e-32
UniRef50_Q04RM8 NADPH-dependent 7-cyano-7-deazaguanine reductase...   141   3e-32
UniRef50_C0GIY6 7-cyano-7-deazaguanine reductase n=1 Tax=Dethiob...   139   1e-31
UniRef50_Q8DNP8 NADPH-dependent 7-cyano-7-deazaguanine reductase...   139   1e-31
UniRef50_Q8DMA3 NADPH-dependent 7-cyano-7-deazaguanine reductase...   137   3e-31
UniRef50_Q2J7K4 NADPH-dependent 7-cyano-7-deazaguanine reductase...   136   7e-31
UniRef50_B2KDU6 NADPH-dependent 7-cyano-7-deazaguanine reductase...   136   9e-31
UniRef50_B8HRW7 7-cyano-7-deazaguanine reductase n=2 Tax=Cyanoba...   136   1e-30
UniRef50_A6Q0W4 NADPH-dependent 7-cyano-7-deazaguanine reductase...   135   1e-30
UniRef50_B5IMF1 7-cyano-7-deazaguanine reductase n=1 Tax=Cyanobi...   133   5e-30
UniRef50_B0CDX9 NADPH-dependent 7-cyano-7-deazaguanine reductase...   133   6e-30
UniRef50_Q113I7 NADPH-dependent 7-cyano-7-deazaguanine reductase...   132   2e-29
UniRef50_C1CXM3 Putative GTP cyclohydrolase I n=2 Tax=Deinococcu...   131   2e-29
UniRef50_B4U9Q5 7-cyano-7-deazaguanine reductase n=5 Tax=Bacteri...   130   4e-29
UniRef50_B0KAC5 NADPH-dependent 7-cyano-7-deazaguanine reductase...   129   8e-29
UniRef50_B7JWF0 7-cyano-7-deazaguanine reductase n=8 Tax=Cyanoba...   128   2e-28
UniRef50_Q5HS73 NADPH-dependent 7-cyano-7-deazaguanine reductase...   128   2e-28
UniRef50_A5IIZ4 NADPH-dependent 7-cyano-7-deazaguanine reductase...   125   1e-27
UniRef50_A8W229 ATP-dependent metalloprotease FtsH n=1 Tax=Bacil...   125   1e-27
UniRef50_B5JRC9 7-cyano-7-deazaguanine reductase n=1 Tax=Verruco...   125   1e-27
UniRef50_B5IBP5 7-cyano-7-deazaguanine reductase n=2 Tax=Aciduli...   120   4e-26
UniRef50_D0MDN3 7-cyano-7-deazaguanine reductase n=1 Tax=Rhodoth...   105   2e-21
UniRef50_Q9YBX9 Putative GTP cyclohydrolase I n=1 Tax=Aeropyrum ...    77   9e-13
UniRef50_A2BLN0 Predicted GTP cyclohydrolase I n=1 Tax=Hyperther...    73   8e-12

Sequences not found previously or not previously below threshold:

UniRef50_B1YDZ8 GTP cyclohydrolase I n=5 Tax=Thermoproteaceae Re...    52   2e-05
UniRef50_B1SCE4 Putative uncharacterized protein n=1 Tax=Strepto...    45   0.004

>UniRef50_Q0T1R0 NADPH-dependent 7-cyano-7-deazaguanine reductase n=139
           Tax=Gammaproteobacteria RepID=QUEF_SHIF8
          Length = 282

 Score =  433 bits (1113), Expect = e-120,   Method: Composition-based stats.
 Identities = 280/282 (99%), Positives = 281/282 (99%)

Query: 1   MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLY 60
           MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLY
Sbjct: 1   MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLY 60

Query: 61  ELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLS 120
           ELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLS
Sbjct: 61  ELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLS 120

Query: 121 TCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEET 180
           TCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENAT GEKVVEET
Sbjct: 121 TCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATSGEKVVEET 180

Query: 181 LVSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDL 240
           LVSHLLKSNCLITHQPDWGS+QIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDL
Sbjct: 181 LVSHLLKSNCLITHQPDWGSIQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDL 240

Query: 241 LRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           LRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ
Sbjct: 241 LRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282


>UniRef50_Q0HGT5 NADPH-dependent 7-cyano-7-deazaguanine reductase n=142
           Tax=Proteobacteria RepID=QUEF_SHESM
          Length = 286

 Score =  398 bits (1022), Expect = e-109,   Method: Composition-based stats.
 Identities = 177/279 (63%), Positives = 219/279 (78%)

Query: 4   YANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELS 63
           Y++ + LAGLTLGK+TDY+  YDASLLQGVPRSLNR+ + L A++LPFHG DIWT YELS
Sbjct: 8   YSDAKELAGLTLGKATDYQAEYDASLLQGVPRSLNRNAINLTAESLPFHGADIWTAYELS 67

Query: 64  WLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCA 123
           WLNAKG P VA+  ++L + S NLIESKSFKLYLNSFNQT+F+N D V++TL +DLS CA
Sbjct: 68  WLNAKGKPMVAIADIQLSHESQNLIESKSFKLYLNSFNQTKFDNIDAVQKTLVQDLSECA 127

Query: 124 QGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVS 183
           QG+++V +        Q +    GTCIDD DI + +Y+F  DYLEN+T  +++V ETL S
Sbjct: 128 QGQVTVKIIEPKSFGIQRVVELPGTCIDDLDIEVSDYDFNPDYLENSTDDKQIVAETLNS 187

Query: 184 HLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRF 243
           +LLKSNCLIT QPDWGS+ I+Y+G +IDREKLLRYL+SFR HNEFHEQCVERIF DL  +
Sbjct: 188 NLLKSNCLITSQPDWGSVMIRYQGPKIDREKLLRYLISFRQHNEFHEQCVERIFVDLKHY 247

Query: 244 CQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           C   KL+VYARYTRRGGLDINP+RS+ +    + RL RQ
Sbjct: 248 CHCTKLTVYARYTRRGGLDINPYRSDFEHPGESHRLARQ 286


>UniRef50_Q7WH69 NADPH-dependent 7-cyano-7-deazaguanine reductase n=5
           Tax=Proteobacteria RepID=QUEF_BORBR
          Length = 273

 Score =  387 bits (994), Expect = e-106,   Method: Composition-based stats.
 Identities = 142/276 (51%), Positives = 173/276 (62%), Gaps = 4/276 (1%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNA 67
            +L+   LG+   Y   YD  LL  +PR+ NR  L L    LPF G D+W  YELSWL+A
Sbjct: 1   MSLSNAPLGQHVAYPSQYDPGLLFPIPRATNRASLQL-GATLPFTGVDLWNAYELSWLDA 59

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKI 127
           +G P+VA+        S N++ESKSFKLYLNSFNQTR  N   +R  LERDL+  A   +
Sbjct: 60  RGKPRVAMATFSFPADSPNIVESKSFKLYLNSFNQTRLPNAQALRDRLERDLAAAAGAPV 119

Query: 128 SVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLK 187
            +            +   +G  ID  DI ID YE     L+ A   E  VEETL + LLK
Sbjct: 120 GLEFISPQRFGELNMAELDGIYIDKLDIEIDTYEPAPQLLQCAPGDE--VEETLATRLLK 177

Query: 188 SNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           SNC +T QPDW SLQ++YRGR IDR  LL+Y+VSFR H EFHE CVERIF D++R CQP 
Sbjct: 178 SNCPVTGQPDWASLQVRYRGRPIDRAALLKYVVSFRQHAEFHEHCVERIFGDIMRACQPR 237

Query: 248 KLSVYARYTRRGGLDINPWRSNSD-FVPSTTRLVRQ 282
           +L+VYARYTRRGGLDINPWRSN +   P+  R  RQ
Sbjct: 238 QLTVYARYTRRGGLDINPWRSNFESAPPADVRTARQ 273


>UniRef50_Q1K442 GTP cyclohydrolase I n=2 Tax=Proteobacteria RepID=Q1K442_DESAC
          Length = 275

 Score =  383 bits (984), Expect = e-105,   Method: Composition-based stats.
 Identities = 148/275 (53%), Positives = 182/275 (66%), Gaps = 1/275 (0%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNA 67
             L  + LGK+T+Y   YDA LL  VPR L RD LG+ ++ LPF+G D+W  YELSWLN 
Sbjct: 2   SDLTEIPLGKTTEYPSQYDAGLLYPVPRHLKRDELGI-SEPLPFYGEDVWNSYELSWLNR 60

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKI 127
           KG P VA+        S NL+ESKSFKLYLNS NQTRF++   V   L+RDLS  +   +
Sbjct: 61  KGKPVVALAVFRFSCQSPNLVESKSFKLYLNSLNQTRFDDQQAVIDCLQRDLSQASGSSV 120

Query: 128 SVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLK 187
           +V L  LD+     +    G C+D  D+ +++Y+   D L +A      VEETL SHLLK
Sbjct: 121 TVELSSLDDQSLWQVQTLPGECLDSVDLDVEHYQLNADLLRDAADSADPVEETLYSHLLK 180

Query: 188 SNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           SNCLIT QPDW S+ I YRG +++R  LL YL+SFR HNEFHEQCVERIF DL+R+C P+
Sbjct: 181 SNCLITSQPDWASVWISYRGGRLERRALLAYLISFRQHNEFHEQCVERIFADLMRYCHPQ 240

Query: 248 KLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
            L+VYARYTRRGGLDINPWRS         RL RQ
Sbjct: 241 SLTVYARYTRRGGLDINPWRSTEPGTAPQWRLSRQ 275


>UniRef50_A4VK37 GTP cyclohydrolase I, putative n=2 Tax=Gammaproteobacteria
           RepID=A4VK37_PSEU5
          Length = 298

 Score =  382 bits (982), Expect = e-105,   Method: Composition-based stats.
 Identities = 142/277 (51%), Positives = 177/277 (63%), Gaps = 2/277 (0%)

Query: 6   NHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWL 65
            H A     LGKS+DY  TY   LL  +PR+     LGL A+ LP+ G D+W  YELSWL
Sbjct: 24  QHPAEHS-PLGKSSDYVATYSPGLLFPIPRAPKWVELGLTAETLPYQGVDLWNCYELSWL 82

Query: 66  NAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQG 125
              G P VA+G  E+   S ++IESKSFKLYLNS NQ+ F + + + + +  DLS  A  
Sbjct: 83  LPSGKPVVAIGEFEIPADSPSIIESKSFKLYLNSLNQSVFESREALAEVMSSDLSAAAGK 142

Query: 126 KISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHL 185
            + V L  LDE+  + +    G C+DD D+TI++Y+     L     G  +VEE+L SHL
Sbjct: 143 PVKVRLRTLDEVAAEGVATLPGRCVDDLDVTIEHYDHPQPGLLACDAG-HMVEESLHSHL 201

Query: 186 LKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQ 245
           LKSNC +T QPDWGS+ ++YRG  +  E LL YLVSFR H +FHEQCVERIF DL R  Q
Sbjct: 202 LKSNCPVTGQPDWGSVVVEYRGAALQAESLLAYLVSFRQHADFHEQCVERIFLDLQRLLQ 261

Query: 246 PEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           PEKL+VYARY RRGGLDINP+RS    V    RLVRQ
Sbjct: 262 PEKLTVYARYVRRGGLDINPYRSTGAMVVDNRRLVRQ 298


>UniRef50_A4T050 GTP cyclohydrolase I n=2 Tax=Proteobacteria RepID=A4T050_POLSQ
          Length = 275

 Score =  380 bits (975), Expect = e-104,   Method: Composition-based stats.
 Identities = 138/275 (50%), Positives = 176/275 (64%), Gaps = 2/275 (0%)

Query: 10  LAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGL-KADNLPFHGTDIWTLYELSWLNAK 68
           +A L LG+ST Y D YD SLL  +PR+ NR  LGL +   LPF G DIW  +ELSWLN K
Sbjct: 1   MATLPLGQSTQYPDQYDPSLLFPIPRTENRAKLGLKEGQALPFVGIDIWNAFELSWLNQK 60

Query: 69  GLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKIS 128
           G PQ+A+   ++   S N+IESKSFKLYLNS N  RF +  +V+  L  DLS  A  K++
Sbjct: 61  GKPQIALAEFQIPADSPNMIESKSFKLYLNSLNSARFEDEGQVKDRLITDLSAVAGSKVA 120

Query: 129 VALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKS 188
             ++  + +  + +   +G  +D  DI ID +      L         +E+ LVSHLLKS
Sbjct: 121 TRIHSTEAVSKKGMQEMSGILMDRLDIEIDPHLPADPSLLGVNESFGPIEQCLVSHLLKS 180

Query: 189 NCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEK 248
           NC +T QPDW S+QI+Y+GR I  E LLRYL+ FR   EFHE CVE IF D+ R C+PEK
Sbjct: 181 NCPVTGQPDWASVQIRYQGRPILEEGLLRYLIGFRQLGEFHEHCVETIFTDIKRQCKPEK 240

Query: 249 LSVYARYTRRGGLDINPWRSNSDFV-PSTTRLVRQ 282
           LSVYARYTRRGGLDINP+R++ +   P  TR  RQ
Sbjct: 241 LSVYARYTRRGGLDINPFRTDHNSPWPENTRHARQ 275


>UniRef50_Q0VR70 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2
           Tax=Alcanivorax RepID=QUEF_ALCBS
          Length = 274

 Score =  377 bits (968), Expect = e-103,   Method: Composition-based stats.
 Identities = 128/273 (46%), Positives = 175/273 (64%), Gaps = 2/273 (0%)

Query: 10  LAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKG 69
           L    LG+S++Y D Y  SLL  VPR   R+ L L++  LPFHG+DIW  YELSWLN KG
Sbjct: 4   LKETPLGRSSEYVDQYMPSLLCPVPRWDAREGLELESATLPFHGSDIWNAYELSWLNEKG 63

Query: 70  LPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISV 129
            P VA+  + +  T+ N++ESKS KLYLNSF  TRF + D VR  +E+D++  A G I V
Sbjct: 64  KPIVAMCELRVPCTTPNIVESKSLKLYLNSFANTRFQSRDAVRAAIEKDVAQTAGGNIEV 123

Query: 130 ALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSN 189
            L+ L E  G P+    G C+D+ D+  ++YE+  D L      E+  +  L SHLL+S+
Sbjct: 124 LLFSLQESAGFPVWEDRGDCVDNIDLNFEHYEYRPDLLLCDQGPEQTGQ--LYSHLLRSH 181

Query: 190 CLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKL 249
           C +T QPDW ++ ++Y GR I     LRY+VS R+H  FHEQ +E++F DL+  C P  L
Sbjct: 182 CPVTDQPDWATVVVRYTGRAISPASFLRYVVSLRNHQGFHEQIIEQMFVDLMTQCSPRHL 241

Query: 250 SVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           +VY R+TRRGG+DINP+RSNS+      R +RQ
Sbjct: 242 TVYGRFTRRGGIDINPFRSNSEQPLPNRRTIRQ 274


>UniRef50_Q5P6G9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=1
           Tax=Aromatoleum aromaticum EbN1 RepID=QUEF_AZOSE
          Length = 283

 Score =  375 bits (964), Expect = e-103,   Method: Composition-based stats.
 Identities = 147/282 (52%), Positives = 180/282 (63%), Gaps = 3/282 (1%)

Query: 2   SSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYE 61
           S   +H A A   LG+S  YRD+Y   LL  + R + RD LGL  D LPF G D+W  YE
Sbjct: 4   SDTHDHGAEAS-PLGQSVVYRDSYAPELLFPIARQIKRDELGLAPDTLPFVGEDLWNAYE 62

Query: 62  LSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLST 121
           LSWLN++G P  A+G   +  TS  LIESKS KLYLNSFNQ RF +   V  TL RDLST
Sbjct: 63  LSWLNSRGKPVAAIGTFRVPVTSPRLIESKSLKLYLNSFNQHRFVDPTLVHDTLTRDLST 122

Query: 122 CAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETL 181
            A   ++V++  L     +  G+ +G  +D+ DI ID Y     +L+ +      V ETL
Sbjct: 123 AAGAPVAVSIEVLSRRPTRVFGYPHGVLLDEIDIEIDTYRTDPAFLQ-SDFNADEVSETL 181

Query: 182 VSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLL 241
            SHLLKSNCL+T QPDWG++ ++Y G  IDR  LLRY+VSFR HNEFHEQCVERIF D+L
Sbjct: 182 YSHLLKSNCLVTGQPDWGTIVLRYIGPPIDRAGLLRYIVSFRSHNEFHEQCVERIFCDVL 241

Query: 242 RFCQPEKLSVYARYTRRGGLDINPWRSNSDFV-PSTTRLVRQ 282
           R C P  L+V+ARYTRRGGLDINP+RS   F        VRQ
Sbjct: 242 RRCAPRHLAVWARYTRRGGLDINPFRSTGHFTQFDNIAEVRQ 283


>UniRef50_Q6ARX8 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2
           Tax=Proteobacteria RepID=QUEF_DESPS
          Length = 276

 Score =  370 bits (949), Expect = e-101,   Method: Composition-based stats.
 Identities = 133/274 (48%), Positives = 172/274 (62%), Gaps = 6/274 (2%)

Query: 11  AGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGL 70
           AG+ LGK   + +TYD S L  V R   R  LGL AD+LPF G DIW  YELSWL++KG 
Sbjct: 7   AGIPLGKQVGHSETYDPSHLFPVARREARKSLGL-ADDLPFSGPDIWNAYELSWLDSKGK 65

Query: 71  PQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVA 130
           P VA+G +    TS N+IESKS KLYLNSFN TRF +   V++ +  DLS  A  ++ V 
Sbjct: 66  PCVALGEITFPCTSENIIESKSLKLYLNSFNLTRFTSTARVKEIIREDLSRVAGAEVEVK 125

Query: 131 LYRLDELEGQPIGHFNGTCIDDQDI--TIDNYEFTTDYLENATCGEKVVEETLVSHLLKS 188
           +   +E     I    G+CIDD ++   I+ Y  T +YL          EE L ++LL++
Sbjct: 126 ILTPEEFTEVTISAPEGSCIDDLELEEEINAYRPTANYLSTGPEE---TEEELYTNLLRT 182

Query: 189 NCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEK 248
           NC +T QPDW ++ I YRG+ ID+  LLRY++SFR H  FHE CVERIF D+L  C P +
Sbjct: 183 NCPVTGQPDWATVIINYRGKAIDQRGLLRYIISFRQHEGFHENCVERIFMDILNRCAPAR 242

Query: 249 LSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           L+VYAR+TRRGGLDINP+R+         RL RQ
Sbjct: 243 LTVYARFTRRGGLDINPYRTTHAEHFVNLRLARQ 276


>UniRef50_Q1LSV9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2
           Tax=Gammaproteobacteria RepID=QUEF_BAUCH
          Length = 283

 Score =  363 bits (932), Expect = 4e-99,   Method: Composition-based stats.
 Identities = 153/281 (54%), Positives = 195/281 (69%), Gaps = 4/281 (1%)

Query: 5   ANHQALAGLTLGKS-TDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELS 63
             +Q L    L KS   YR  Y+  LLQ +PR+++R+ LG+ + +LPF G D WTLYELS
Sbjct: 4   QQYQLLQKFKLDKSKISYRTHYNPMLLQPIPRTIHRELLGISSISLPFQGADFWTLYELS 63

Query: 64  WLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCA 123
           WLN  GLPQVA+G + +D TS NLIES+S KLYLNS NQT F++  E+R TL  D++ C 
Sbjct: 64  WLNKYGLPQVAIGEMIIDATSDNLIESQSLKLYLNSINQTCFSSEQELRNTLITDITKCI 123

Query: 124 QGKISVALYRLDELEGQPIGHFNGTCIDDQDITI--DNYEFTTDYLENATCGEKVVEETL 181
             ++ + ++ L +    PI  F G CID+Q I I  DNY F ++ L N+   EK V+ETL
Sbjct: 124 NSQVKITIHSLSQWMTVPILEFTGECIDNQSIQIDNDNYIFNSNLLVNSVEREK-VKETL 182

Query: 182 VSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLL 241
           VSHLLKSNC IT+QPDWGS+QI Y G +I+RE LLRYL+SFR +  FHEQCVE+I+ D++
Sbjct: 183 VSHLLKSNCPITNQPDWGSVQISYYGMRINREALLRYLISFRKYKIFHEQCVEQIYCDIM 242

Query: 242 RFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           +FC P  LSVY RY RRGGLDINPWRSN  + P    L RQ
Sbjct: 243 QFCLPNTLSVYVRYNRRGGLDINPWRSNISYSPVNRPLARQ 283


>UniRef50_Q5X7D5 NADPH-dependent 7-cyano-7-deazaguanine reductase n=43 Tax=Bacteria
           RepID=QUEF_LEGPA
          Length = 285

 Score =  360 bits (925), Expect = 2e-98,   Method: Composition-based stats.
 Identities = 134/271 (49%), Positives = 180/271 (66%), Gaps = 6/271 (2%)

Query: 15  LGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVA 74
           LG++ +Y   Y+   L  +PR+  R  + L  ++  F+G D W  YE+SWLN+KG P VA
Sbjct: 18  LGQTANYDSYYNPKRLYPIPRAPKRQEINLDPNSTTFYGFDCWNHYEVSWLNSKGKPVVA 77

Query: 75  VGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRL 134
           +  +  D  S  +IESKS KLY NS N + F + + V QT+ +DLS C   +++V +Y L
Sbjct: 78  MAVISYDCHSPCIIESKSLKLYFNSLNNSTFPDVETVVQTISKDLSHCIGSEVAVNVYPL 137

Query: 135 DELEGQPI-GHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLIT 193
            E+  Q I   F+G C+D  DI    Y    D+L  ++   K+VEE L S LLKSNCL+T
Sbjct: 138 SEIASQTIYAAFDGICLDKLDIECSVYHVMPDFLSTSS---KLVEEVLYSDLLKSNCLVT 194

Query: 194 HQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYA 253
           +QPDWGS+QI Y+G++I+ E LL+YL+SFR+HNEFHEQC+ERIF D++RFCQPE L+VY 
Sbjct: 195 NQPDWGSVQIIYKGKKINHEGLLKYLISFRNHNEFHEQCIERIFADIMRFCQPESLAVYG 254

Query: 254 RYTRRGGLDINPWRSNS--DFVPSTTRLVRQ 282
           RYTRRGGLDINP RS     F     RL+RQ
Sbjct: 255 RYTRRGGLDINPIRSTEPCAFDGQNIRLIRQ 285


>UniRef50_Q21VW6 NADPH-dependent 7-cyano-7-deazaguanine reductase n=143
           Tax=Proteobacteria RepID=QUEF_RHOFD
          Length = 289

 Score =  359 bits (921), Expect = 7e-98,   Method: Composition-based stats.
 Identities = 140/287 (48%), Positives = 175/287 (60%), Gaps = 17/287 (5%)

Query: 11  AGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGL 70
               LG++T Y D YDASLL  + R+  R  +G+    LPF G D+WT +ELSWLN +G 
Sbjct: 5   QNSPLGQATAYLDQYDASLLFPIARATKRAEIGVTG-ALPFLGADMWTAFELSWLNLRGK 63

Query: 71  PQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTC-------- 122
           PQVA+    +   S N+IESKSFKLYLNSFN TRF + D V+  L  DLS          
Sbjct: 64  PQVALARFTVPCESPNIIESKSFKLYLNSFNNTRFADVDAVKARLRADLSEAVWRDAGKN 123

Query: 123 ------AQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKV 176
                 A   I V L   +  + +PI   +G  +D  D+   +Y    D L      E  
Sbjct: 124 VSPDAAAPPSIGVTLLLPELFDREPIYELDGLSLDRLDVECTHYTPAPDLL-RVVPDEAP 182

Query: 177 VEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERI 236
           V E LVS+LLKSNC +T QPDW S+QI Y G  ID+E LL+YLVSFR+HNEFHEQCVERI
Sbjct: 183 VSEVLVSNLLKSNCPVTGQPDWASVQISYSGAPIDQEGLLQYLVSFRNHNEFHEQCVERI 242

Query: 237 FNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDF-VPSTTRLVRQ 282
           F DL   C+P +L+VYARYTRRGGLDINP+R++    +P+  R  RQ
Sbjct: 243 FMDLWTRCKPVRLAVYARYTRRGGLDINPFRTSYAQALPANVRNARQ 289


>UniRef50_Q6FA61 NADPH-dependent 7-cyano-7-deazaguanine reductase n=16
           Tax=Acinetobacter RepID=QUEF_ACIAD
          Length = 271

 Score =  357 bits (917), Expect = 2e-97,   Method: Composition-based stats.
 Identities = 120/277 (43%), Positives = 165/277 (59%), Gaps = 8/277 (2%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLG-LKADNLPFHGTDIWTLYELSWLN 66
            ++    LGK T+Y  TY  S+L  + R   R+    ++  +    G D W ++ELSWLN
Sbjct: 1   MSVEQSLLGKETEYPTTYSPSVLFPISRDAAREKYAQIEGIS---QGKDWWHVFELSWLN 57

Query: 67  AKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGK 126
           +  +PQVA+G + L  TS  LIESKS KLY NS N   F +  E+   +E+DLS  A  K
Sbjct: 58  SDNIPQVAIGRITLPATSPYLIESKSLKLYFNSLNFHVFASKQELIDLVEKDLSQAANAK 117

Query: 127 ISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLL 186
           +S+ L+ +D LE   I   +G CIDD              L+     +   + TL SHLL
Sbjct: 118 VSLELFDVDSLE---ISKPSGMCIDDLKPERLESHPDASLLKLDANEQHDADVTLYSHLL 174

Query: 187 KSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQP 246
           +SNC +T QPDWG++ I+Y GR+     +L Y++S+R HN FHEQCVE+I+ D+ +  QP
Sbjct: 175 RSNCPVTGQPDWGTVFIRYTGRKHCYRSILAYIISYRQHNGFHEQCVEQIYADIWKNLQP 234

Query: 247 EKLSVYARYTRRGGLDINPWR-SNSDFVPSTTRLVRQ 282
           EKL VYA YTRRGGLDINP R S+  ++P+  RL RQ
Sbjct: 235 EKLMVYATYTRRGGLDINPCRVSDLSWMPNPIRLARQ 271


>UniRef50_B8KG68 NADPH-dependent 7-cyano-7-deazaguanine reductase (Nadph-dependent
           nitrile oxidoreductase) n=1 Tax=gamma proteobacterium
           NOR5-3 RepID=B8KG68_9GAMM
          Length = 276

 Score =  349 bits (895), Expect = 7e-95,   Method: Composition-based stats.
 Identities = 114/285 (40%), Positives = 157/285 (55%), Gaps = 12/285 (4%)

Query: 1   MSSYANHQALA---GLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIW 57
           M  + +   +A   G  LG+       YD  LL  VPR+  R    L        G DIW
Sbjct: 1   MGDHHSAPGVAHDKGPLLGRQVAGSHYYDPGLLFPVPRANARK--SLPGGAFAGFGEDIW 58

Query: 58  TLYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLER 117
             YELSWLNA G+PQ+ +G   +   S N+IESKSFKLYLNS N   F +    R+T+ R
Sbjct: 59  HAYELSWLNASGMPQMFLGTFSVPADSANIIESKSFKLYLNSLNNFEFASDGLARETIVR 118

Query: 118 DLSTCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVV 177
           DLS  A  ++S+ L  +D+          G C+D   +++   E   + LE      +V 
Sbjct: 119 DLSAVAGAQVSLVLKAVDDQRYDG-RVLEGDCLDGFQVSVPE-EPHVELLEPVVGDARVY 176

Query: 178 EETLVSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIF 237
                +HL++S C +T QPDW ++ I+ RG    R+KLL YL+++R+H EFHEQCVER++
Sbjct: 177 -----THLMRSLCPVTAQPDWATMIIETRGTSAQRDKLLSYLLAYRNHQEFHEQCVERVY 231

Query: 238 NDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
            DL +  +P+ LSV A YTRRGGLDI PWR +        R+ RQ
Sbjct: 232 TDLWKRLEPDYLSVQALYTRRGGLDICPWRCSEARPAPQGRMNRQ 276


>UniRef50_C8PYF2 Queuine synthase n=3 Tax=Moraxellaceae RepID=C8PYF2_9GAMM
          Length = 283

 Score =  348 bits (894), Expect = 1e-94,   Method: Composition-based stats.
 Identities = 118/275 (42%), Positives = 165/275 (60%), Gaps = 8/275 (2%)

Query: 15  LGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVA 74
           LG+ST Y  TY   +L  +PR+L R  L L AD L   G D W ++E+SWLN+ G+ QVA
Sbjct: 10  LGQSTSYPKTYAPDMLYPIPRALGRAKLALPADALSI-GMDWWQVFEMSWLNSHGISQVA 68

Query: 75  VGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRL 134
           +  + +  TS  ++ESKS KLY NS N T F+N   V+  +E+DLS C +  +++ ++ +
Sbjct: 69  MVRLAIPATSDYIVESKSLKLYFNSLNFTEFDNQQAVKAAVEKDLSACLKTDVTLEIFEV 128

Query: 135 DELEGQPIGHFNGTCIDDQ------DITIDNYEFTTDYLENATCGEKVVEETLVSHLLKS 188
           +     PI    G CID+        I I +   ++              + L SHLL+S
Sbjct: 129 NIANSLPISAPQGDCIDNALDNSGKKIAIVSDVDSSSLTVADQGASDSQLQILHSHLLRS 188

Query: 189 NCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEK 248
           NC +T+QPDWG+L+IQ   + IDR  LL Y++SFR HN FHEQCVE+IF+DL +   P+ 
Sbjct: 189 NCPVTNQPDWGTLEIQIDSQPIDRAGLLEYILSFRQHNGFHEQCVEQIFSDLTQAFAPKT 248

Query: 249 LSVYARYTRRGGLDINPWR-SNSDFVPSTTRLVRQ 282
           L V A YTRRGG+DINP R S+   +P  +RL RQ
Sbjct: 249 LMVRAWYTRRGGIDINPCRVSDISLLPPPSRLNRQ 283


>UniRef50_A4A3I6 GTP cyclohydrolase I n=1 Tax=Congregibacter litoralis KT71
           RepID=A4A3I6_9GAMM
          Length = 272

 Score =  344 bits (883), Expect = 2e-93,   Method: Composition-based stats.
 Identities = 118/272 (43%), Positives = 158/272 (58%), Gaps = 9/272 (3%)

Query: 11  AGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGL 70
            G  LG+     + YD SLL  VPRS  R    L        G DIW  YELSWL+A G+
Sbjct: 10  KGPLLGQQVVGSEQYDPSLLFPVPRSNARA--SLPEQRFQGFGEDIWHAYELSWLSAAGM 67

Query: 71  PQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVA 130
           PQ  VG   +  TS NLIESKS KLYLNS N  RF + +  RQT+ RDLS  A   +S+ 
Sbjct: 68  PQAFVGTFAIPATSANLIESKSLKLYLNSLNNHRFTSAEAARQTIVRDLSEVAGAPVSLT 127

Query: 131 LYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNC 190
           L   ++   +      G+C+DD ++T+   +     L     G+ +    L +HL++S C
Sbjct: 128 LGSPEDPAFRG-EDLPGSCLDDLEVTVP--DAADPVLLTGVAGDGL----LYTHLMRSLC 180

Query: 191 LITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLS 250
            +T QPDW ++ ++ RG   +   LLRYL+++R+H EFHEQCVERI+ D+L   QP+ LS
Sbjct: 181 PVTAQPDWATVVVETRGVAPESPGLLRYLLAYRNHQEFHEQCVERIYTDILDRLQPDYLS 240

Query: 251 VYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           V+A YTRRGGLDI+PWR +        RL RQ
Sbjct: 241 VHALYTRRGGLDISPWRCSEHQPAPRYRLNRQ 272


>UniRef50_A8F0H9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=14
           Tax=Rickettsia RepID=QUEF_RICM5
          Length = 273

 Score =  341 bits (876), Expect = 1e-92,   Method: Composition-based stats.
 Identities = 120/277 (43%), Positives = 172/277 (62%), Gaps = 6/277 (2%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNA 67
             L+   LGK + Y+D+YD +LL  +PR  NR+ LG+ ++NLPF+G D+W  YELS LN 
Sbjct: 1   MPLSTSLLGKKSTYKDSYDVTLLFKIPRINNRNELGINSNNLPFYGVDVWNTYELSCLNK 60

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKI 127
            G P V VG   +   S N++ESKSFKLYLNSFN     +  E+ + + +DLS     K+
Sbjct: 61  NGKPWVGVGTFYIPTDSENIVESKSFKLYLNSFNNFVVESVKELERIILQDLSNVTHAKV 120

Query: 128 SVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLK 187
           +  ++ ++       G  +G  IDD DI  +NY    + L      + +VEE + S+LLK
Sbjct: 121 TGRIFPIN--TKVEFGVPSGKNIDDLDIVCNNYGAPDNSL--IEYEDVLVEEEINSNLLK 176

Query: 188 SNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPE 247
           SNCL+T QPDWG++ I+Y+G+++  +  L+YL+SFR+ NEF EQC ERIF D+     P+
Sbjct: 177 SNCLVTGQPDWGTIVIKYKGKKLKHDSFLKYLISFRNCNEFAEQCAERIFTDIKNAISPD 236

Query: 248 KLSVYARYTRRGGLDINPWRSNSDF--VPSTTRLVRQ 282
            LS+   YTRRGG+DI P+RS      +PS  R +RQ
Sbjct: 237 FLSISIVYTRRGGIDICPYRSTDKSYTLPSDKRFIRQ 273


>UniRef50_Q1QDK8 NADPH-dependent 7-cyano-7-deazaguanine reductase n=3
           Tax=Psychrobacter RepID=QUEF_PSYCK
          Length = 285

 Score =  340 bits (873), Expect = 3e-92,   Method: Composition-based stats.
 Identities = 115/286 (40%), Positives = 167/286 (58%), Gaps = 12/286 (4%)

Query: 8   QALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNA 67
            ++ G+   ++TDY   Y    L  + RS+ R+ +G + D L   G D W  +ELSWLN 
Sbjct: 1   MSIHGILGEQTTDYPTEYSPETLYPIARSMGREVIGWQDDKLE-VGFDWWQAFELSWLNE 59

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKI 127
           +G+ QVA+    +  +S  ++ESKS KLYLNS N T F + + V+  + +DLS C Q ++
Sbjct: 60  QGISQVAIARFGIPASSPFIVESKSLKLYLNSINFTEFGSLETVQTLIAKDLSKCVQAEV 119

Query: 128 SVALYRL-DELEGQPIGHFNGTCIDDQ-----DITIDNYEFTTDYLENATCGEKVVEET- 180
           +V L+ L DE  G  I   +G CIDD      +            LE  T   K+ E   
Sbjct: 120 NVELFDLEDEHSGLLIAQPDGICIDDALADSTEKVALTLHPDASLLERNTSDAKISEGKT 179

Query: 181 --LVSHLLKSNCLITHQPDWGSLQIQYRG-RQIDREKLLRYLVSFRHHNEFHEQCVERIF 237
               S+LL+SNC +T+QPDWG+L +     + ++   +LRY++SFR HN FHEQCVE+IF
Sbjct: 180 FSFYSNLLRSNCPVTNQPDWGTLAVSITSNKPVNNANMLRYILSFRQHNGFHEQCVEQIF 239

Query: 238 NDLLRFCQPEKLSVYARYTRRGGLDINPWR-SNSDFVPSTTRLVRQ 282
            DL ++ +P +L V A YTRRGG+DINP R S+   +P  +RL+RQ
Sbjct: 240 ADLSQYYEPSELMVRAWYTRRGGIDINPCRVSDIALLPVPSRLIRQ 285


>UniRef50_B8KRQ4 NADPH-dependent 7-cyano-7-deazaguanine reductase n=1 Tax=gamma
           proteobacterium NOR51-B RepID=B8KRQ4_9GAMM
          Length = 267

 Score =  331 bits (848), Expect = 2e-89,   Method: Composition-based stats.
 Identities = 102/274 (37%), Positives = 140/274 (51%), Gaps = 8/274 (2%)

Query: 10  LAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKG 69
           +    LG   D    Y   +L+ V R    + L       P  G D+W LYELSWL+ +G
Sbjct: 1   MVDRVLGSRVDAPTRYSPEILEPVERQRGDERLS------PMLGADVWHLYELSWLSREG 54

Query: 70  LPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISV 129
            P   VG + +  +S   +ESKS KLYLNS N  RF+N      T+ RD+       + +
Sbjct: 55  WPTAFVGALAIPASSPRTVESKSLKLYLNSLNFHRFDNERAAVSTIMRDVQAVVGASVDL 114

Query: 130 ALYRLDELEGQPIGHFNGTCIDD-QDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKS 188
            +    EL  Q      G CIDD     +   ++        + GE  V ETL+SH L+S
Sbjct: 115 TIAAPTEL-AQWTREPAGVCIDDVFSGALVAADWGASRKTPFSQGEDRVSETLISHQLRS 173

Query: 189 NCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEK 248
            C +T QPDWG+L + Y G ++D  +LL ++ SFR H +FHE CVE+I+  L     PE 
Sbjct: 174 LCPVTGQPDWGTLVVDYSGYRLDPAELLSFVCSFREHQDFHEHCVEQIYKKLFGDLSPEA 233

Query: 249 LSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           L+V A Y RRGG+DI PWR +        R+ RQ
Sbjct: 234 LTVTAYYQRRGGIDITPWRGHEKLDAPLWRMGRQ 267


>UniRef50_A0Z1W1 Putative uncharacterized protein n=1 Tax=marine gamma
           proteobacterium HTCC2080 RepID=A0Z1W1_9GAMM
          Length = 267

 Score =  329 bits (843), Expect = 8e-89,   Method: Composition-based stats.
 Identities = 103/273 (37%), Positives = 144/273 (52%), Gaps = 6/273 (2%)

Query: 10  LAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKG 69
           +A   LG+       Y   +L+ + R   R+ LG    ++   G D W LYELSWLN + 
Sbjct: 1   MAVHALGQKVAAPKRYAPDILEAISRREGREALGPAPKSM--VGHDCWHLYELSWLNLRN 58

Query: 70  LPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISV 129
            PQ  VG + +D  S   IESKS KLYLNS N   F +  +  + +  D+    Q  +S+
Sbjct: 59  EPQHCVGVLLVDSASPATIESKSLKLYLNSLNFHCFASEAQACEVICGDIGRVTQSDVSL 118

Query: 130 ALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSN 189
            +   D L         G  ++      D+    + +      G+ +++ T VSH L+S 
Sbjct: 119 TVLPPDGLGA-ITREPEGVLLEADPQQSDHTSMQSPW---CDSGDDILDATYVSHRLRSL 174

Query: 190 CLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKL 249
           C +T QPDWG+L I YRGR I+  +LL ++ SFR H EFHEQCVER F ++++    E L
Sbjct: 175 CPVTAQPDWGTLVIDYRGRPINHHRLLGFIESFREHQEFHEQCVERCFYEVMKQTNAESL 234

Query: 250 SVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
            V A Y RRGG+DI P RSN   VP   R+ RQ
Sbjct: 235 RVSAFYQRRGGIDITPVRSNHRVVPELWRMGRQ 267


>UniRef50_P44165 Uncharacterized protein HI1340 n=9 Tax=Gammaproteobacteria
           RepID=Y1340_HAEIN
          Length = 441

 Score =  298 bits (763), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 129/281 (45%), Positives = 171/281 (60%), Gaps = 18/281 (6%)

Query: 3   SYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFH-GTDIWTLYE 61
           +Y +  +L  L LG+ T+Y   YD +LLQ VPR+LNRD LG+   N PF  G DIWT YE
Sbjct: 2   NYQD-NSLKSLKLGQKTEYASQYDRTLLQPVPRALNRDGLGIT-QNQPFTIGADIWTAYE 59

Query: 62  LSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLST 121
           +SWLN KGLPQVA+  + LDY S NLIESKSFKLYLNSFNQ++F +++ V+QT++RDLS 
Sbjct: 60  ISWLNEKGLPQVAIADIYLDYQSQNLIESKSFKLYLNSFNQSKFTDFNAVQQTMQRDLSE 119

Query: 122 CAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETL 181
           CAQG + V L  +   + Q I H  G CID+QDI I +YEF  ++L++    E +VEE L
Sbjct: 120 CAQGDVKVRLNPVAVYDAQKINHLQGDCIDEQDIEITSYEFNANWLKDCVSNE-IVEEKL 178

Query: 182 VSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIF---- 237
           VSHLLKSNCLIT+QPDWG+ Q Q         KL     +F    +  EQ +  +     
Sbjct: 179 VSHLLKSNCLITNQPDWGTDQAQQAILTARNNKL-----NFETQRKTAEQTLRNLLNLKP 233

Query: 238 NDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTR 278
           N+ L    P  ++V     +  G+++N   S     P    
Sbjct: 234 NEALNITFPHIMNV-----KTAGVNLNVPVSVIANRPDVKA 269


>UniRef50_Q6WI29 GTP cyclohydrolase I family protein n=1 Tax=Vibrio phage KVP40
           RepID=Q6WI29_BPKV4
          Length = 302

 Score =  282 bits (722), Expect = 9e-75,   Method: Composition-based stats.
 Identities = 99/288 (34%), Positives = 138/288 (47%), Gaps = 16/288 (5%)

Query: 1   MSSYANHQALAGLTLGKST-DYRDTYD-----ASLLQGVPRSLNRDPLGLKADNLPFHGT 54
           MS+Y    A+A   LGK   DY D  D       LL  +PR LNR   G+   N  F G 
Sbjct: 1   MSNYDQVSAIAAEHLGKKAGDYSDFVDIVEVRPDLLVPIPRELNRTDYGIT--NEDFAGF 58

Query: 55  DIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQ-----TRFNNWD 109
           D W  +E+S L  +GLP   +  V     S N++ESKS KLY NSFN      TR    D
Sbjct: 59  DTWHGFEVSALTEQGLPVSGMAKVVYPSDSPNIVESKSMKLYWNSFNMAKVAATRAEVKD 118

Query: 110 EVRQTLERDLSTCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLEN 169
            +     RDLS      + V+ +   E   QP G      +D        ++  +    +
Sbjct: 119 AIEAIASRDLSEVIGAPVQVSFFT--EKLTQPHGMTGFAELDKYVSESTVFDSESGADAD 176

Query: 170 ATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQIDR-EKLLRYLVSFRHHNEF 228
                 + +  + +  L+SNC +THQPD+G L +   G +    + L++Y+VSFR  N F
Sbjct: 177 LLQESHIKKLKVFTPNLRSNCRVTHQPDFGDLYVYMSGEKTPTVDSLMQYIVSFRKENHF 236

Query: 229 HEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPST 276
           HE+CVE I+  LL    P +L V A YTRRGG +I P R+  + +   
Sbjct: 237 HEECVEMIYKALLDKFDPTELMVTALYTRRGGWNICPARATHEELLPE 284


>UniRef50_B7RUV0 GTP cyclohydrolase I subfamily, putative n=1 Tax=marine gamma
           proteobacterium HTCC2148 RepID=B7RUV0_9GAMM
          Length = 168

 Score =  216 bits (550), Expect = 7e-55,   Method: Composition-based stats.
 Identities = 77/172 (44%), Positives = 111/172 (64%), Gaps = 4/172 (2%)

Query: 111 VRQTLERDLSTCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENA 170
           +R+TL++D+       I + L  +D +E    G  +G CIDD  I+ID+     + L+  
Sbjct: 1   MRETLKKDIENTVGASIELELLPVDAVELDG-GIPDGLCIDDLQISIDSSPPGVNLLQ-- 57

Query: 171 TCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHE 230
             GE++VEE + SHLL+S C +T QPDW ++ ++YRGR +  E LLRYL++FR H EFHE
Sbjct: 58  -AGEELVEEAVYSHLLRSLCPVTGQPDWATVYVRYRGRALTHESLLRYLIAFRKHQEFHE 116

Query: 231 QCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ 282
           QCVER++ D+ +   PE L + A YTRRGGLDINP+RS+       +R+ RQ
Sbjct: 117 QCVERMYCDIHKLVSPEFLEIQAFYTRRGGLDINPFRSSDANPIPLSRMNRQ 168


>UniRef50_B8DRK9 7-cyano-7-deazaguanine reductase n=2 Tax=Desulfovibrio
           RepID=B8DRK9_DESVM
          Length = 188

 Score =  165 bits (418), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 24/136 (17%), Positives = 50/136 (36%), Gaps = 5/136 (3%)

Query: 152 DQDITIDNYEFTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG-- 207
                  +       LE       ++    ++      S C +T QPD+ ++  +Y    
Sbjct: 39  GVKAEYPHAGPGPHILEAFPNNFPDRPYIVSIAFPEFTSLCPVTGQPDFATIVTEYIPDQ 98

Query: 208 RQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWR 267
           R ++ +    Y+ ++R+H  F E     + + +     P    V   +T RGG  ++ + 
Sbjct: 99  RCVESKSFKLYMFAYRNHQSFMETITNTVLDHMTEALDPLWCRVKGLFTPRGGTHLHVFA 158

Query: 268 SNSDFVPSTT-RLVRQ 282
                V      +VR+
Sbjct: 159 ERFKQVEEPRAAMVRE 174



 Score = 62.3 bits (150), Expect = 2e-08,   Method: Composition-based stats.
 Identities = 24/124 (19%), Positives = 42/124 (33%), Gaps = 15/124 (12%)

Query: 2   SSYANHQALAGLT--LGKSTDYRDT-YDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWT 58
           ++Y   Q   G    LG   +Y        +L+  P +    P  +      F       
Sbjct: 23  AAYTRSQDQTGHLRTLGVKAEYPHAGPGPHILEAFPNNFPDRPYIVSIAFPEFT------ 76

Query: 59  LYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERD 118
               S     G P  A    E        +ESKSFKLY+ ++   + +  + +  T+   
Sbjct: 77  ----SLCPVTGQPDFATIVTEYIPD-QRCVESKSFKLYMFAYRNHQ-SFMETITNTVLDH 130

Query: 119 LSTC 122
           ++  
Sbjct: 131 MTEA 134


>UniRef50_A9VKS1 NADPH-dependent 7-cyano-7-deazaguanine reductase n=310 Tax=Bacteria
           RepID=QUEF_BACWK
          Length = 165

 Score =  165 bits (417), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 35/111 (31%), Positives = 58/111 (52%), Gaps = 4/111 (3%)

Query: 160 YEFTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKL 215
           +E++ + LE        +            S C  T QPD+ ++ I Y    R ++ + L
Sbjct: 24  FEYSPEILEVFDNNHPNRDYFVKFNCPEFTSLCPKTGQPDFATIYISYIPEQRMVESKSL 83

Query: 216 LRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW 266
             YL SFR+H +FHE C+  I NDL++   P  + V+ ++T RGG+ I+P+
Sbjct: 84  KLYLFSFRNHGDFHEDCMNVIMNDLIKLMDPRYIEVWGKFTPRGGISIDPY 134



 Score = 73.8 bits (180), Expect = 6e-12,   Method: Composition-based stats.
 Identities = 25/108 (23%), Positives = 39/108 (36%), Gaps = 13/108 (12%)

Query: 13  LTLG-KSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLP 71
             LG ++T Y   Y   +L+    +       +K +   F           S     G P
Sbjct: 13  TLLGNQNTKYLFEYSPEILEVFDNNHPNRDYFVKFNCPEFT----------SLCPKTGQP 62

Query: 72  QVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDL 119
             A  ++        ++ESKS KLYL SF      + D +   +  DL
Sbjct: 63  DFATIYISYIPE-QRMVESKSLKLYLFSFRNHGDFHEDCM-NVIMNDL 108


>UniRef50_Q2IH01 NADPH-dependent 7-cyano-7-deazaguanine reductase n=5 Tax=Bacteria
           RepID=QUEF_ANADE
          Length = 122

 Score =  163 bits (412), Expect = 8e-39,   Method: Composition-based stats.
 Identities = 26/109 (23%), Positives = 45/109 (41%), Gaps = 2/109 (1%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHN 226
                 +  E  +        C +T QPD+ +++++Y    R ++ + L  YL SFR   
Sbjct: 13  PNPKPGRPFEIAMECPEFTCVCPMTGQPDFATIRLRYVPAERCVELKSLKLYLWSFRDEG 72

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPS 275
            FHE    RI +DL+    P  + V   +  RGG+       + +    
Sbjct: 73  TFHEAVTNRICDDLVAALAPRWIEVVGDFAVRGGIHTVVTARHGERPAG 121



 Score = 58.0 bits (139), Expect = 4e-07,   Method: Composition-based stats.
 Identities = 20/93 (21%), Positives = 27/93 (29%), Gaps = 12/93 (12%)

Query: 30  LQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIE 89
           LQ  P      P  +  +   F                 G P  A   +     +   +E
Sbjct: 9   LQTFPNPKPGRPFEIAMECPEFTCV----------CPMTGQPDFATIRLRYVP-AERCVE 57

Query: 90  SKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTC 122
            KS KLYL SF        + V   +  DL   
Sbjct: 58  LKSLKLYLWSFRD-EGTFHEAVTNRICDDLVAA 89


>UniRef50_B3E3W5 7-cyano-7-deazaguanine reductase n=3 Tax=Proteobacteria
           RepID=B3E3W5_GEOLS
          Length = 144

 Score =  162 bits (409), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 36/120 (30%), Positives = 53/120 (44%), Gaps = 2/120 (1%)

Query: 151 DDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--R 208
           D  D  +  +  +                 +        C +T QPD+G++ I Y+   R
Sbjct: 21  DAPDAGLLEWFPSPYVDPELNPCGCTGTLHISCPEFTCLCPMTGQPDFGTIIIDYQPDQR 80

Query: 209 QIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRS 268
            ++ + L  YL SFR H EFHE  V RI NDL++   P  L+V   +T RGG+   P   
Sbjct: 81  CVESKSLKLYLGSFRMHGEFHEAGVNRICNDLVKLLDPVWLTVKGEFTPRGGIPFWPTAE 140



 Score = 64.6 bits (156), Expect = 4e-09,   Method: Composition-based stats.
 Identities = 33/143 (23%), Positives = 45/143 (31%), Gaps = 11/143 (7%)

Query: 7   HQALAGLTLGKSTDYR-DTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWL 65
           H+ L  L  GK+T Y  D  DA LL+  P       L          GT   +  E + L
Sbjct: 4   HEGLKTLGEGKATTYSYDAPDAGLLEWFPSPYVDPELNPCGCT----GTLHISCPEFTCL 59

Query: 66  NA-KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQ 124
               G P      ++        +ESKS KLYL SF        +     +  DL     
Sbjct: 60  CPMTGQPDFGTIIIDYQPD-QRCVESKSLKLYLGSFRMH-GEFHEAGVNRICNDLVKLLD 117

Query: 125 G---KISVALYRLDELEGQPIGH 144
                +         +   P   
Sbjct: 118 PVWLTVKGEFTPRGGIPFWPTAE 140


>UniRef50_C7JB01 Queuosine biosynthesis protein QueF n=9 Tax=Alphaproteobacteria
           RepID=C7JB01_ACEP3
          Length = 178

 Score =  162 bits (409), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 32/111 (28%), Positives = 49/111 (44%), Gaps = 2/111 (1%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHN 226
            A   +K       +    S C IT QPD+  + I Y   +  ++ + L  YL SFR+H 
Sbjct: 55  PAPYPDKHYLVRFTAPEFTSLCPITGQPDFAHIVIDYVPDKWIVESKSLKLYLTSFRNHG 114

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTT 277
            FHE C  +I N L+    P  L + A +  RGG+ I+ +    +      
Sbjct: 115 AFHEACSIQIANTLVERLAPRWLRIGAYWYPRGGIPIDVFWQTGEPPAGVW 165



 Score = 61.5 bits (148), Expect = 3e-08,   Method: Composition-based stats.
 Identities = 22/100 (22%), Positives = 34/100 (34%), Gaps = 11/100 (11%)

Query: 15  LGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVA 74
           LGK      + + ++L+ VP         ++     F           S     G P  A
Sbjct: 36  LGKQVAAPQSPEEAILERVPAPYPDKHYLVRFTAPEFT----------SLCPITGQPDFA 85

Query: 75  VGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQT 114
              ++       ++ESKS KLYL SF      +     Q 
Sbjct: 86  HIVIDYVPDK-WIVESKSLKLYLTSFRNHGAFHEACSIQI 124


>UniRef50_Q3SJI1 NADPH-dependent 7-cyano-7-deazaguanine reductase n=9 Tax=Bacteria
           RepID=QUEF_THIDA
          Length = 139

 Score =  159 bits (403), Expect = 9e-38,   Method: Composition-based stats.
 Identities = 29/120 (24%), Positives = 46/120 (38%), Gaps = 7/120 (5%)

Query: 167 LENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSF 222
           LE        +     +        C  T QPD+ +L + Y      ++ + L  Y+ SF
Sbjct: 9   LETFPNPKPGRDFHIHMEVPEFTCLCPKTGQPDFATLVLDYIPNQACVELKSLKLYMWSF 68

Query: 223 RHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW---RSNSDFVPSTTRL 279
           R    FHE    RI +DL+    P  + + A++  RGG+  N     R +         L
Sbjct: 69  RDEGHFHEDVTNRILDDLVAATDPRYMRLTAKFYVRGGIFTNVVAEHRKDGWQPAPRVDL 128



 Score = 47.3 bits (111), Expect = 7e-04,   Method: Composition-based stats.
 Identities = 18/94 (19%), Positives = 27/94 (28%), Gaps = 12/94 (12%)

Query: 30  LQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIE 89
           L+  P         +  +   F                 G P  A   ++        +E
Sbjct: 9   LETFPNPKPGRDFHIHMEVPEFT----------CLCPKTGQPDFATLVLDYIPN-QACVE 57

Query: 90  SKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCA 123
            KS KLY+ SF      + D V   +  DL    
Sbjct: 58  LKSLKLYMWSFRDEGHFHED-VTNRILDDLVAAT 90


>UniRef50_C4XPJ6 Putative uncharacterized protein n=1 Tax=Desulfovibrio magneticus
           RS-1 RepID=C4XPJ6_DESMR
          Length = 143

 Score =  159 bits (402), Expect = 1e-37,   Method: Composition-based stats.
 Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 4/110 (3%)

Query: 163 TTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRY 218
           T   LE       ++  + T  S    S C  T QPD+G++ I+Y      I+ + L  Y
Sbjct: 28  TPGLLETFPNAFPDRRYDITFASDEFTSLCPKTGQPDFGTITIRYVPDKLCIESKSLKLY 87

Query: 219 LVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRS 268
           L S+R    F E    RI +DL+  CQP  + V   +  RGG+ I+   +
Sbjct: 88  LFSYRDEGAFMETLTNRILDDLVEVCQPHHMEVTGDFAARGGITISVTAT 137



 Score = 93.9 bits (232), Expect = 5e-18,   Method: Composition-based stats.
 Identities = 25/121 (20%), Positives = 37/121 (30%), Gaps = 15/121 (12%)

Query: 5   ANHQALAGLTLGK-STDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELS 63
            +   L    LG+ +T Y       LL+  P +       +   +  F           S
Sbjct: 8   DDVSTLKT--LGQGATVYPRNVTPGLLETFPNAFPDRRYDITFASDEFT----------S 55

Query: 64  WLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCA 123
                G P      +         IESKS KLYL S+        + +   +  DL    
Sbjct: 56  LCPKTGQPDFGTITIRYVPDK-LCIESKSLKLYLFSYRD-EGAFMETLTNRILDDLVEVC 113

Query: 124 Q 124
           Q
Sbjct: 114 Q 114


>UniRef50_Q0AAV5 NADPH-dependent 7-cyano-7-deazaguanine reductase n=11 Tax=Bacteria
           RepID=QUEF_ALHEH
          Length = 129

 Score =  158 bits (399), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 30/121 (24%), Positives = 46/121 (38%), Gaps = 7/121 (5%)

Query: 167 LENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSF 222
           LE       E+     +        C  T QPD+ ++ + Y    R ++ + L  Y+ SF
Sbjct: 9   LETFPNPRPERDFVLHMRIPEFTCLCPKTGQPDFATIHLDYVPDERCVELKSLKLYMWSF 68

Query: 223 RHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW---RSNSDFVPSTTRL 279
           R    FHE     I +DL+R  +P  + V A +  RGG+        R           L
Sbjct: 69  RDQGAFHEAITNEILDDLVRATEPRYMKVTAEFYVRGGIYTTVVAEHRKPGWAPAPKVEL 128

Query: 280 V 280
            
Sbjct: 129 A 129



 Score = 50.0 bits (118), Expect = 1e-04,   Method: Composition-based stats.
 Identities = 17/64 (26%), Positives = 26/64 (40%), Gaps = 3/64 (4%)

Query: 61  ELSWLNAK-GLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDL 119
           E + L  K G P  A  H++        +E KS KLY+ SF   +    + +   +  DL
Sbjct: 29  EFTCLCPKTGQPDFATIHLDYVPD-ERCVELKSLKLYMWSFRD-QGAFHEAITNEILDDL 86

Query: 120 STCA 123
               
Sbjct: 87  VRAT 90


>UniRef50_C7M0Q2 7-cyano-7-deazaguanine reductase n=1 Tax=Acidimicrobium
           ferrooxidans DSM 10331 RepID=C7M0Q2_ACIFD
          Length = 155

 Score =  157 bits (397), Expect = 4e-37,   Method: Composition-based stats.
 Identities = 39/127 (30%), Positives = 58/127 (45%), Gaps = 7/127 (5%)

Query: 161 EFTTDYLENATCGEKV--VEETLVSHLLKSNCLITHQPDWGSLQIQYR--GRQIDREKLL 216
           +     LE     +    +   L +    S C +T QPD+G L I Y    R ++ + L 
Sbjct: 21  DPDPSVLETFPTPQPSGGLVIRLFALEFTSLCPVTGQPDYGQLDIVYVPGPRCVESKSLK 80

Query: 217 RYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWR---SNSDFV 273
            YL+ FR+H  FHE CV ++  DL     P  L V  R+  RGG+ I P R   ++ +  
Sbjct: 81  LYLMRFRNHGAFHEACVAQVAQDLASVLAPRYLRVIGRFNARGGIAIWPLREVVADHEDP 140

Query: 274 PSTTRLV 280
            +   LV
Sbjct: 141 AALRALV 147



 Score = 68.8 bits (167), Expect = 2e-10,   Method: Composition-based stats.
 Identities = 34/172 (19%), Positives = 53/172 (30%), Gaps = 18/172 (10%)

Query: 5   ANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSW 64
            +   L  L   + T   D  D S+L+  P       L ++   L F           S 
Sbjct: 2   DDSITLQALGSSRQTYAYDDPDPSVLETFPTPQPSGGLVIRLFALEFT----------SL 51

Query: 65  LNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQ 124
               G P      +         +ESKS KLYL  F      +   V Q + +DL++   
Sbjct: 52  CPVTGQPDYGQLDIVYVP-GPRCVESKSLKLYLMRFRNHGAFHEACVAQ-VAQDLASVLA 109

Query: 125 GKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKV 176
            +    + R +   G  I        D +D            L +   G + 
Sbjct: 110 PRYLRVIGRFNARGGIAIWPLREVVADHEDPAALRA------LVDLDNGARP 155


>UniRef50_B8IYG6 NADPH-dependent 7-cyano-7-deazaguanine reductase n=6
           Tax=Desulfovibrionaceae RepID=QUEF_DESDA
          Length = 167

 Score =  156 bits (395), Expect = 8e-37,   Method: Composition-based stats.
 Identities = 28/134 (20%), Positives = 51/134 (38%), Gaps = 6/134 (4%)

Query: 155 ITIDNYEFTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QI 210
           +T      +   LE       ++    ++      S C +T QPD G++ ++Y      +
Sbjct: 20  LTSPEGGPSVALLEAFPNCFPQRPYVISISFPEFTSLCPVTGQPDCGTITVEYIPDELCV 79

Query: 211 DREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNS 270
           + +    Y+ +FR+H  F E     +  DL     P    V   +  RGG  I+ +    
Sbjct: 80  ESKSFKLYMFAFRNHQSFMETITNNVLEDLRALLNPCWCRVKGLFAPRGGTRIHVFAEAF 139

Query: 271 D--FVPSTTRLVRQ 282
                   + LVR+
Sbjct: 140 KDGMPEEQSALVRE 153



 Score = 58.8 bits (141), Expect = 2e-07,   Method: Composition-based stats.
 Identities = 26/119 (21%), Positives = 40/119 (33%), Gaps = 12/119 (10%)

Query: 3   SYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYEL 62
           S    + L  L  G+ T        +LL+  P    + P  +      F           
Sbjct: 5   SQDQTRDLKVLGTGRLTSPEGGPSVALLEAFPNCFPQRPYVISISFPEFT---------- 54

Query: 63  SWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLST 121
           S     G P      VE        +ESKSFKLY+ +F   + +  + +   +  DL  
Sbjct: 55  SLCPVTGQPDCGTITVEYIPD-ELCVESKSFKLYMFAFRNHQ-SFMETITNNVLEDLRA 111


>UniRef50_Q9ZJJ9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=12
           Tax=Helicobacter RepID=QUEF_HELPJ
          Length = 148

 Score =  154 bits (389), Expect = 4e-36,   Method: Composition-based stats.
 Identities = 38/111 (34%), Positives = 60/111 (54%), Gaps = 4/111 (3%)

Query: 160 YEFTTDYLENATCGEKVVE--ETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKL 215
           +E+ +D LE        ++   TL      S C IT QPD+G + I+Y  +   ++ + L
Sbjct: 18  FEYNSDLLEAFPNPNPNLDPLITLECKEFTSLCPITSQPDFGVIFIRYIPKDKMVESKSL 77

Query: 216 LRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW 266
             YL S+R+H  FHE C+  I  DL++  +P+ L VY  +  RGG+ I P+
Sbjct: 78  KLYLFSYRNHGSFHESCINTILLDLVQLLEPKYLEVYGDFVSRGGIAIKPF 128



 Score = 66.9 bits (162), Expect = 8e-10,   Method: Composition-based stats.
 Identities = 24/107 (22%), Positives = 36/107 (33%), Gaps = 12/107 (11%)

Query: 15  LGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVA 74
           LG  T Y   Y++ LL+  P         +  +   F           S       P   
Sbjct: 10  LGAKTPYIFEYNSDLLEAFPNPNPNLDPLITLECKEFT----------SLCPITSQPDFG 59

Query: 75  VGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLST 121
           V  +        ++ESKS KLYL S+      +   +  T+  DL  
Sbjct: 60  VIFIRYIP-KDKMVESKSLKLYLFSYRNHGSFHESCI-NTILLDLVQ 104


>UniRef50_D2L9R9 7-cyano-7-deazaguanine reductase n=1 Tax=Desulfovibrio sp. FW1012B
           RepID=D2L9R9_9DELT
          Length = 145

 Score =  153 bits (388), Expect = 5e-36,   Method: Composition-based stats.
 Identities = 35/109 (32%), Positives = 49/109 (44%), Gaps = 4/109 (3%)

Query: 163 TTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRY 218
           T   LE        +    T  S    S C  T QPD+G + I+Y    R I+ + L  Y
Sbjct: 32  TPGLLETFPNAFPGRRYTVTFASEEFTSLCPKTGQPDFGMITIRYVPDERCIESKSLKLY 91

Query: 219 LVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWR 267
           L S+R    F E    RI +DL+  CQP ++ V   +  RGG+ I+   
Sbjct: 92  LFSYRDEGTFMETLTNRILDDLVAACQPLEMEVTGDFAARGGITISVTA 140



 Score =  105 bits (261), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 29/145 (20%), Positives = 45/145 (31%), Gaps = 17/145 (11%)

Query: 5   ANHQALAGLTLGK-STDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELS 63
            +   L    LG+ +T Y  T    LL+  P +       +   +  F           S
Sbjct: 12  DDVSTLTT--LGQGATAYPRTVTPGLLETFPNAFPGRRYTVTFASEEFT----------S 59

Query: 64  WLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCA 123
                G P   +  +         IESKS KLYL S+        + +   +  DL    
Sbjct: 60  LCPKTGQPDFGMITIRYVPD-ERCIESKSLKLYLFSYRD-EGTFMETLTNRILDDLVAAC 117

Query: 124 QGKISVALY-RLDELEGQPIGHFNG 147
           Q  + + +        G  I    G
Sbjct: 118 Q-PLEMEVTGDFAARGGITISVTAG 141


>UniRef50_Q8GJN6 NADPH-dependent 7-cyano-7-deazaguanine reductase n=98 Tax=cellular
           organisms RepID=QUEF_SYNE7
          Length = 174

 Score =  153 bits (387), Expect = 5e-36,   Method: Composition-based stats.
 Identities = 31/120 (25%), Positives = 48/120 (40%), Gaps = 4/120 (3%)

Query: 162 FTTDYLENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLR 217
                LE       ++      V+    S C +T QPD+  L + Y   Q  ++ + L  
Sbjct: 42  PEVAVLETFDNPHPDRQYLVRFVAPEFTSLCPLTGQPDFAHLVLDYVPDQRLVESKSLKL 101

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTT 277
           +L SFR+H  FHE C   I   L     P  L +   +  RGGL I+ +  + +      
Sbjct: 102 FLGSFRNHGAFHENCTLTIAKRLEEAMNPTWLRLGGYWYPRGGLPIDVFYQSGEPPAGVW 161



 Score = 59.6 bits (143), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 21/122 (17%), Positives = 37/122 (30%), Gaps = 12/122 (9%)

Query: 3   SYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYEL 62
           S           LG+      + + ++L+            ++     F           
Sbjct: 20  SLQKFMTETLTQLGQMVGLPASPEVAVLETFDNPHPDRQYLVRFVAPEFT---------- 69

Query: 63  SWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTC 122
           S     G P  A   ++       L+ESKS KL+L SF      + +    T+ + L   
Sbjct: 70  SLCPLTGQPDFAHLVLDYVPD-QRLVESKSLKLFLGSFRNHGAFHENCTL-TIAKRLEEA 127

Query: 123 AQ 124
             
Sbjct: 128 MN 129


>UniRef50_Q8UD54 NADPH-dependent 7-cyano-7-deazaguanine reductase n=45
           Tax=Alphaproteobacteria RepID=QUEF_AGRT5
          Length = 154

 Score =  153 bits (387), Expect = 6e-36,   Method: Composition-based stats.
 Identities = 31/120 (25%), Positives = 47/120 (39%), Gaps = 4/120 (3%)

Query: 162 FTTDYLENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLR 217
                LE    G           +    S C +T QPD+  + I Y      ++ + L  
Sbjct: 22  PEKAVLEKVPNGNAGTDYVVRFTAPEFTSLCPMTGQPDFAHIVIDYIPGDFLVESKSLKL 81

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTT 277
           +L SFR+H  FHE C   I   L+   QP+ L + A +  RGG+ I+ +           
Sbjct: 82  FLQSFRNHGAFHEDCSVYIAKRLVELLQPKWLRIGAYWYPRGGIPIDVFWQTGAAPEGVW 141



 Score = 63.4 bits (153), Expect = 9e-09,   Method: Composition-based stats.
 Identities = 31/150 (20%), Positives = 49/150 (32%), Gaps = 24/150 (16%)

Query: 3   SYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYEL 62
           S  +   L+   LG   D  ++ + ++L+ VP         ++     F           
Sbjct: 2   SVTDVSGLSQ--LGTKVDTPESPEKAVLEKVPNGNAGTDYVVRFTAPEFT---------- 49

Query: 63  SWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTC 122
           S     G P  A   ++       L+ESKS KL+L SF      + D      +R     
Sbjct: 50  SLCPMTGQPDFAHIVIDYIP-GDFLVESKSLKLFLQSFRNHGAFHEDCSVYIAKR----- 103

Query: 123 AQGKISVALYRLDELEGQPIGHFN-GTCID 151
                 V L +   L      +   G  ID
Sbjct: 104 -----LVELLQPKWLRIGAYWYPRGGIPID 128


>UniRef50_Q6MRJ2 NADPH-dependent 7-cyano-7-deazaguanine reductase n=1
           Tax=Bdellovibrio bacteriovorus RepID=QUEF_BDEBA
          Length = 170

 Score =  152 bits (383), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 36/110 (32%), Positives = 57/110 (51%), Gaps = 4/110 (3%)

Query: 162 FTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLR 217
           +  + LE        K+   T V     S C  T QPD+  + I Y   +  ++ + L  
Sbjct: 28  YAPEVLEAFDNKNPGKIAWTTFVCTEFTSLCPKTRQPDFAKIFINYIADKKMVESKSLKL 87

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWR 267
           YL SFR+H +FHE CV+ I +DL++  +P+ + V   +T RGG+ I P+ 
Sbjct: 88  YLFSFRNHGDFHEDCVQTICDDLVKLMKPKYIEVIGEFTPRGGIAIYPYA 137



 Score = 96.6 bits (239), Expect = 8e-19,   Method: Composition-based stats.
 Identities = 35/129 (27%), Positives = 54/129 (41%), Gaps = 21/129 (16%)

Query: 3   SYANHQALAGLTLGKS-TDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLY- 60
           +  + + LA   LG+S T+Y +TY   +L+                     G   WT + 
Sbjct: 5   NGRDSKELADFALGESQTNYPETYAPEVLEAFDNKNP--------------GKIAWTTFV 50

Query: 61  --ELSWLNAKGLPQVAVGHVELDYTSVN-LIESKSFKLYLNSFNQTRFNNWDEVRQTLER 117
             E + L  K   Q     + ++Y +   ++ESKS KLYL SF      + D V QT+  
Sbjct: 51  CTEFTSLCPKTR-QPDFAKIFINYIADKKMVESKSLKLYLFSFRNHGDFHEDCV-QTICD 108

Query: 118 DLSTCAQGK 126
           DL    + K
Sbjct: 109 DLVKLMKPK 117


>UniRef50_A6C8E2 Putative uncharacterized protein n=2 Tax=Planctomycetaceae
           RepID=A6C8E2_9PLAN
          Length = 121

 Score =  152 bits (383), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 32/120 (26%), Positives = 51/120 (42%), Gaps = 4/120 (3%)

Query: 158 DNYEFTTDYLENATCGE--KVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQI--DRE 213
              E + + LE        +      V     S C  T QPD+G+L I Y   ++  + +
Sbjct: 2   SENEASRELLETFENPHPHRDYVMETVCPEFTSVCPKTGQPDYGTLIITYIPDKVCFELK 61

Query: 214 KLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFV 273
            L  YL S+R+   F+E    RI +DL+    P  + + A +T RGG+      S+    
Sbjct: 62  SLKMYLQSYRNVGAFYEDVTNRILDDLVAITDPRWMELRAEFTPRGGISSTVTVSHHKED 121



 Score = 43.4 bits (101), Expect = 0.008,   Method: Composition-based stats.
 Identities = 18/98 (18%), Positives = 25/98 (25%), Gaps = 12/98 (12%)

Query: 26  DASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSV 85
              LL+            ++     F           S     G P      +      V
Sbjct: 7   SRELLETFENPHPHRDYVMETVCPEFT----------SVCPKTGQPDYGTLIITYIPDKV 56

Query: 86  NLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCA 123
              E KS K+YL S+        D V   +  DL    
Sbjct: 57  -CFELKSLKMYLQSYRNVGAFYED-VTNRILDDLVAIT 92


>UniRef50_A1WY83 NADPH-dependent 7-cyano-7-deazaguanine reductase n=5 Tax=Bacteria
           RepID=QUEF_HALHL
          Length = 118

 Score =  151 bits (382), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 24/104 (23%), Positives = 42/104 (40%), Gaps = 2/104 (1%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRHHN 226
                E+     +        C  T QPD+ +L ++Y      ++ + L  Y+ S+R   
Sbjct: 13  ENPNPERDYTIRMEIPEFTCLCPKTGQPDFATLNLEYIPERHCVELKSLKLYIWSYRDVG 72

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNS 270
            FHE    +I  DL+   QP  + + A +  RGG+       + 
Sbjct: 73  GFHEALTNQILGDLVAATQPRYMKLTAHFNVRGGIWTTVEAEHH 116



 Score = 45.7 bits (107), Expect = 0.002,   Method: Composition-based stats.
 Identities = 16/95 (16%), Positives = 30/95 (31%), Gaps = 12/95 (12%)

Query: 30  LQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIE 89
           L+            ++ +   F                 G P  A  ++E      + +E
Sbjct: 9   LETFENPNPERDYTIRMEIPEFT----------CLCPKTGQPDFATLNLEYIPER-HCVE 57

Query: 90  SKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQ 124
            KS KLY+ S+      + + +   +  DL    Q
Sbjct: 58  LKSLKLYIWSYRDVGGFH-EALTNQILGDLVAATQ 91


>UniRef50_Q2LTJ0 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2 Tax=Bacteria
           RepID=QUEF_SYNAS
          Length = 140

 Score =  149 bits (377), Expect = 1e-34,   Method: Composition-based stats.
 Identities = 28/103 (27%), Positives = 43/103 (41%), Gaps = 4/103 (3%)

Query: 167 LENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSF 222
           LE       ++    T+ +      C +T QPD+  L I Y      ++ + L  YL S+
Sbjct: 26  LETFPNRHPDRDYIVTMETAEFTCVCPMTGQPDFADLHISYIPDASILESKSLKLYLWSY 85

Query: 223 RHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINP 265
           R+   FHE     I  D++    P    V A +  RGG+ I  
Sbjct: 86  RNEGIFHEHVTNVILEDVVAALSPRWCKVTANFGVRGGISITV 128



 Score = 52.7 bits (125), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 18/93 (19%), Positives = 30/93 (32%), Gaps = 12/93 (12%)

Query: 30  LQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIE 89
           L+  P         +  +   F                 G P  A  H+     + +++E
Sbjct: 26  LETFPNRHPDRDYIVTMETAEFTCV----------CPMTGQPDFADLHISYIPDA-SILE 74

Query: 90  SKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTC 122
           SKS KLYL S+      +   V   +  D+   
Sbjct: 75  SKSLKLYLWSYRNEGIFHEH-VTNVILEDVVAA 106


>UniRef50_D1N404 7-cyano-7-deazaguanine reductase n=3 Tax=Bacteria
           RepID=D1N404_9BACT
          Length = 142

 Score =  146 bits (369), Expect = 7e-34,   Method: Composition-based stats.
 Identities = 33/109 (30%), Positives = 50/109 (45%), Gaps = 4/109 (3%)

Query: 161 EFTTDYLENA--TCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLL 216
                 LE       ++            S C +T QPD+G + ++Y      I+ + L 
Sbjct: 25  RPEEARLEAFRNVYADRDYIIEFDCPEYTSLCPVTGQPDFGHIILRYVPDKLCIESKSLK 84

Query: 217 RYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINP 265
            YL SFR+ N FHE+ V  I + +++ C P K  V  R+  RGG+ IN 
Sbjct: 85  LYLYSFRNTNTFHEESVNTILDAVVKTCAPRKAEVIGRFRPRGGIAINV 133



 Score = 60.0 bits (144), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 23/121 (19%), Positives = 39/121 (32%), Gaps = 13/121 (10%)

Query: 20  DYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVE 79
           +Y    + + L+            ++ D   +           S     G P      + 
Sbjct: 21  NYPTRPEEARLEAFRNVYADRDYIIEFDCPEYT----------SLCPVTGQPDFGHIILR 70

Query: 80  LDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCA--QGKISVALYRLDEL 137
                   IESKS KLYL SF  T   + + V   L+  + TCA  + ++         +
Sbjct: 71  YVPDK-LCIESKSLKLYLYSFRNTNTFHEESVNTILDAVVKTCAPRKAEVIGRFRPRGGI 129

Query: 138 E 138
            
Sbjct: 130 A 130


>UniRef50_B2UN89 7-cyano-7-deazaguanine reductase n=2 Tax=Verrucomicrobiaceae
           RepID=B2UN89_AKKM8
          Length = 136

 Score =  146 bits (369), Expect = 7e-34,   Method: Composition-based stats.
 Identities = 36/122 (29%), Positives = 58/122 (47%), Gaps = 6/122 (4%)

Query: 161 EFTTDYLENATC-GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLR 217
                 LE+    G +    TL +H   S C +T QPD   L I Y    + ++ + L  
Sbjct: 18  NPDDARLESFPNRGTRPYTITLDTHEFSSLCPVTGQPDSCHLTITYVPAEKCVETKSLKY 77

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTT 277
           YL ++R++  F+EQ V RI +DL+    P  L V  R++ RGG+ +    + ++  P   
Sbjct: 78  YLAAYRNYPAFNEQIVNRITDDLVAAISPRWLKVEGRFSPRGGIQLT---ATAEHNPENR 134

Query: 278 RL 279
            L
Sbjct: 135 PL 136



 Score = 54.6 bits (130), Expect = 4e-06,   Method: Composition-based stats.
 Identities = 24/143 (16%), Positives = 41/143 (28%), Gaps = 20/143 (13%)

Query: 5   ANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSW 64
            +H  L    LG  + +    D + L+  P    R P  +  D   F           S 
Sbjct: 3   DDHLTL----LGSQSSFFTNPDDARLESFPNRGTR-PYTITLDTHEFS----------SL 47

Query: 65  LNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQ 124
               G P      +     +   +E+KS K YL ++      N   +   +  DL     
Sbjct: 48  CPVTGQPDSCHLTITYVP-AEKCVETKSLKYYLAAYRNYPAFNEQ-IVNRITDDLVAAIS 105

Query: 125 G---KISVALYRLDELEGQPIGH 144
               K+         ++      
Sbjct: 106 PRWLKVEGRFSPRGGIQLTATAE 128


>UniRef50_B3QM19 NADPH-dependent 7-cyano-7-deazaguanine reductase n=4 Tax=Bacteria
           RepID=QUEF_CHLP8
          Length = 116

 Score =  144 bits (363), Expect = 4e-33,   Method: Composition-based stats.
 Identities = 27/111 (24%), Positives = 47/111 (42%), Gaps = 4/111 (3%)

Query: 162 FTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLR 217
              + +E        +     +V+    S C  T  PD+G++ I Y      I+ + L  
Sbjct: 1   MNKEIIEVFDNTFPNRDYTIEIVNPEFTSVCPKTGLPDFGTITITYVPDKSCIELKSLKY 60

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRS 268
           Y + FR+   F+E     I + L+  CQP+ ++V   +  RGG+      S
Sbjct: 61  YFLEFRNAGIFYENITNTILDHLVEACQPKSMTVKTDWNARGGITETVTVS 111



 Score = 45.7 bits (107), Expect = 0.002,   Method: Composition-based stats.
 Identities = 17/99 (17%), Positives = 28/99 (28%), Gaps = 12/99 (12%)

Query: 28  SLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNL 87
            +++    +       ++  N  F           S     GLP      +       + 
Sbjct: 4   EIIEVFDNTFPNRDYTIEIVNPEFT----------SVCPKTGLPDFGTITITYVPDK-SC 52

Query: 88  IESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGK 126
           IE KS K Y   F        + +  T+   L    Q K
Sbjct: 53  IELKSLKYYFLEFRNAGIFYEN-ITNTILDHLVEACQPK 90


>UniRef50_A8ZUH0 GTP cyclohydrolase I n=2 Tax=Desulfobacteraceae RepID=A8ZUH0_DESOH
          Length = 134

 Score =  142 bits (359), Expect = 1e-32,   Method: Composition-based stats.
 Identities = 30/109 (27%), Positives = 51/109 (46%), Gaps = 2/109 (1%)

Query: 166 YLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFR 223
            +E A    + ++  +      S C +T  PD+G + I+YR R   ++ + L  YL+ +R
Sbjct: 26  VIEYAYRETRPIDVVIRQPEFTSLCPMTGLPDYGCITIRYRPRHHIVELKSLKYYLLQYR 85

Query: 224 HHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDF 272
           +   F+E  + RI NDL     P  + V   +T RGG+      +  D 
Sbjct: 86  NVGIFYEHVINRILNDLSGAVAPVWMEVSGEFTARGGITTTVTAATGDQ 134


>UniRef50_D2REX4 GTP cyclohydrolase I n=1 Tax=Archaeoglobus profundus DSM 5631
           RepID=D2REX4_ARCPR
          Length = 236

 Score =  142 bits (358), Expect = 1e-32,   Method: Composition-based stats.
 Identities = 35/182 (19%), Positives = 63/182 (34%), Gaps = 26/182 (14%)

Query: 106 NNWDEVRQTLERDLSTCAQGKISVALY---RLDELEGQPIGHFNGTCIDDQDITIDNYEF 162
           +N +  R+ + RDL  C +  + V +        +    I    G  +           +
Sbjct: 47  DNEELCREIVTRDLELCEKADVIVLVAKHPSFGAMAEVVISAMKGKPVVAFCPEKVRSPW 106

Query: 163 TTDY--------------LENATCGEKVVEETLVSHL-------LKSNCLITHQPDWGSL 201
              +              L+      + +      H            C +T   D G++
Sbjct: 107 PIYFANKVVRSEEELVRALKELETPLRTIPNVYSDHEAEFTYTKFTCICPVTGLRDIGTI 166

Query: 202 QIQYRG--RQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRG 259
           +I+Y+   R ++ E L  Y   F      HE  V ++FND+ +   PE L V A +  R 
Sbjct: 167 KIRYKPKDRILEYESLDSYFKLFADKKMHHEAVVCKVFNDIYQALNPEWLEVVAEFEERS 226

Query: 260 GL 261
           G+
Sbjct: 227 GV 228


>UniRef50_B3EMR0 NADPH-dependent 7-cyano-7-deazaguanine reductase n=9 Tax=Bacteria
           RepID=QUEF_CHLPB
          Length = 118

 Score =  142 bits (357), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 27/111 (24%), Positives = 48/111 (43%), Gaps = 4/111 (3%)

Query: 162 FTTDYLENATC--GEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLR 217
              + LE       ++     +V+    S C IT  PD+G++ I+Y      ++ + L  
Sbjct: 1   MQKELLEVFDNRFPDRDYTIEIVNPEFTSVCPITGLPDFGTITIRYIPDKVCVELKSLKY 60

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRS 268
           Y + FR+   F+E     I + L+   +P  L+V   +  RGG+      S
Sbjct: 61  YYLEFRNAGIFYENVTNTILDHLVDLLKPRTLTVTTAWKARGGITETVTVS 111



 Score = 40.7 bits (94), Expect = 0.063,   Method: Composition-based stats.
 Identities = 18/92 (19%), Positives = 25/92 (27%), Gaps = 12/92 (13%)

Query: 28  SLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNL 87
            LL+            ++  N  F           S     GLP      +      V  
Sbjct: 4   ELLEVFDNRFPDRDYTIEIVNPEFT----------SVCPITGLPDFGTITIRYIPDKV-C 52

Query: 88  IESKSFKLYLNSFNQTRFNNWDEVRQTLERDL 119
           +E KS K Y   F        + V  T+   L
Sbjct: 53  VELKSLKYYYLEFRNAGIFYEN-VTNTILDHL 83


>UniRef50_B7J648 NADPH-dependent 7-cyano-7-deazaguanine reductase n=22 Tax=Bacteria
           RepID=QUEF_ACIF2
          Length = 141

 Score =  142 bits (357), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 28/111 (25%), Positives = 43/111 (38%), Gaps = 5/111 (4%)

Query: 170 ATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNE 227
               E+     +        C +T QPD+    + +   Q  ++ + L  YL SFR    
Sbjct: 14  NPHPERDYVVHMDLPEFTCLCPLTGQPDFAHFMLDFIPDQHNVELKSLKLYLWSFRDEGA 73

Query: 228 FHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPW---RSNSDFVPS 275
           FHE    RI +DL+    P  L +  R+  RGG+  +     R      P 
Sbjct: 74  FHEAMTNRIADDLIGLINPRYLRLLGRWYVRGGITTDVLIEHRQPGWQNPD 124



 Score = 44.2 bits (103), Expect = 0.005,   Method: Composition-based stats.
 Identities = 17/60 (28%), Positives = 24/60 (40%), Gaps = 3/60 (5%)

Query: 61  ELSWLNA-KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDL 119
           E + L    G P  A   ++      N +E KS KLYL SF        + +   +  DL
Sbjct: 29  EFTCLCPLTGQPDFAHFMLDFIPDQHN-VELKSLKLYLWSFRD-EGAFHEAMTNRIADDL 86


>UniRef50_Q04RM8 NADPH-dependent 7-cyano-7-deazaguanine reductase n=6 Tax=Leptospira
           RepID=QUEF_LEPBJ
          Length = 133

 Score =  141 bits (356), Expect = 3e-32,   Method: Composition-based stats.
 Identities = 27/102 (26%), Positives = 41/102 (40%), Gaps = 2/102 (1%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHN 226
                 K            + C  T  PD+G + + Y    R I+ +    Y++S+R+  
Sbjct: 28  TNVYEGKDYTIDFTVPEFTAVCPKTGLPDFGVIYVSYVPTKRCIELKSFKEYILSYRNVG 87

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRS 268
            FHE  V +I  DL+    P+ L V   Y  RGG+     R 
Sbjct: 88  VFHEFLVNKIMEDLIAAIDPKYLKVIGDYNARGGIKTVVTRE 129



 Score = 48.0 bits (113), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 26/119 (21%), Positives = 38/119 (31%), Gaps = 22/119 (18%)

Query: 18  STDYRDTYD------ASL----LQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNA 67
            T++ +TYD       SL    ++            +      F                
Sbjct: 2   KTNHPETYDGRQDHIPSLKTPEIESFTNVYEGKDYTIDFTVPEFTAV----------CPK 51

Query: 68  KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGK 126
            GLP   V +V    T    IE KSFK Y+ S+      +   V + +E DL      K
Sbjct: 52  TGLPDFGVIYVSYVPTK-RCIELKSFKEYILSYRNVGVFHEFLVNKIME-DLIAAIDPK 108


>UniRef50_C0GIY6 7-cyano-7-deazaguanine reductase n=1 Tax=Dethiobacter alkaliphilus
           AHT 1 RepID=C0GIY6_9FIRM
          Length = 130

 Score =  139 bits (351), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 33/114 (28%), Positives = 45/114 (39%), Gaps = 2/114 (1%)

Query: 159 NYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLL 216
           N       LE       V    L S  + S C +T QPDW ++ I+Y      I+ + L 
Sbjct: 11  NVPEPRRKLEVFEKPAGVDRVVLESDEVTSLCPVTGQPDWETVIIEYEPDRYCIESKSLK 70

Query: 217 RYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNS 270
            Y  SFR    F E    +I ND+   C+P    V      RGG+ I    +  
Sbjct: 71  LYFWSFRQEGVFCEGLAAQIANDVHAACKPFFCKVTVIQKPRGGITITASATAG 124



 Score = 46.1 bits (108), Expect = 0.001,   Method: Composition-based stats.
 Identities = 18/70 (25%), Positives = 27/70 (38%), Gaps = 5/70 (7%)

Query: 63  SWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTC 122
           S     G P      +E +      IESKS KLY  SF Q      + +   +  D+   
Sbjct: 40  SLCPVTGQPDWETVIIEYEPDR-YCIESKSLKLYFWSFRQ-EGVFCEGLAAQIANDVHAA 97

Query: 123 AQG---KISV 129
            +    K++V
Sbjct: 98  CKPFFCKVTV 107


>UniRef50_Q8DNP8 NADPH-dependent 7-cyano-7-deazaguanine reductase n=26
           Tax=Streptococcus pneumoniae RepID=QUEF_STRR6
          Length = 154

 Score =  139 bits (350), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 36/123 (29%), Positives = 62/123 (50%), Gaps = 5/123 (4%)

Query: 155 ITIDNYEFTTDY-LENATCGEKVVEETLVSHLLKSNCL--ITHQPDWGSLQIQYRGR--Q 209
           +    + +   + LE     E   E+ +  H+L  + L  IT QPD+ ++ I Y      
Sbjct: 7   VEAVTFAYGQHHHLEIQITREIAKEQGIRHHILDMSLLGQITAQPDFATIHISYIPDKLC 66

Query: 210 IDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSN 269
           ++ + L  YL S+R+H +FHE C+  I  DL+    P  L V+ ++T RGG+ I+P+ + 
Sbjct: 67  VESKSLKLYLFSYRNHGDFHENCINTIGKDLVNLLDPRYLEVWGKFTPRGGISIDPYYNY 126

Query: 270 SDF 272
              
Sbjct: 127 GKQ 129



 Score = 54.6 bits (130), Expect = 4e-06,   Method: Composition-based stats.
 Identities = 22/91 (24%), Positives = 33/91 (36%), Gaps = 12/91 (13%)

Query: 58  TLYELSWLNA-KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLE 116
            + ++S L      P  A  H+         +ESKS KLYL S+      + + +  T+ 
Sbjct: 37  HILDMSLLGQITAQPDFATIHISYIPDK-LCVESKSLKLYLFSYRNHGDFHENCI-NTIG 94

Query: 117 RDLSTCAQGKISVALYRLDELEGQPIGHFNG 147
           +DL         V L     LE        G
Sbjct: 95  KDL---------VNLLDPRYLEVWGKFTPRG 116


>UniRef50_Q8DMA3 NADPH-dependent 7-cyano-7-deazaguanine reductase n=14 Tax=Bacteria
           RepID=QUEF_THEEB
          Length = 132

 Score =  137 bits (346), Expect = 3e-31,   Method: Composition-based stats.
 Identities = 17/106 (16%), Positives = 40/106 (37%), Gaps = 2/106 (1%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHN 226
                 +     +        C  +  PD+ +L + Y    + ++ + +  Y+ S+R   
Sbjct: 22  PNPRPGRQYTIEITLPEFTCKCPFSGYPDFATLYVSYIPHEKVVELKAIKLYINSYRDRY 81

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDF 272
             HE+ V ++ +DL+  C P  + +   +  RG +       +   
Sbjct: 82  ISHEEAVNQVLDDLVAACDPLYMKIKGDFAPRGNVHTVITVEHHRQ 127



 Score = 43.4 bits (101), Expect = 0.008,   Method: Composition-based stats.
 Identities = 19/96 (19%), Positives = 30/96 (31%), Gaps = 12/96 (12%)

Query: 28  SLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNL 87
             L   P         ++     F                 G P  A  +V        +
Sbjct: 16  GQLITFPNPRPGRQYTIEITLPEFTCK----------CPFSGYPDFATLYVSYIPH-EKV 64

Query: 88  IESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCA 123
           +E K+ KLY+NS+     ++ + V Q L  DL    
Sbjct: 65  VELKAIKLYINSYRDRYISHEEAVNQVL-DDLVAAC 99


>UniRef50_Q2J7K4 NADPH-dependent 7-cyano-7-deazaguanine reductase n=4
           Tax=Actinomycetales RepID=QUEF_FRASC
          Length = 125

 Score =  136 bits (343), Expect = 7e-31,   Method: Composition-based stats.
 Identities = 31/99 (31%), Positives = 47/99 (47%), Gaps = 2/99 (2%)

Query: 167 LENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRH 224
           LE     +   E  +        C IT QPDW +++I YR   R ++ + L  YL +FR 
Sbjct: 17  LETFPIDDTSQEIRIDCREFTCRCPITGQPDWATIRIDYRPGGRGLETKSLKLYLETFRE 76

Query: 225 HNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDI 263
              FHE     I +DL+    P +L+V   +  RGG+ +
Sbjct: 77  EGIFHEHLATLIRDDLVAALAPVQLTVTVNFNARGGIAL 115



 Score = 40.3 bits (93), Expect = 0.079,   Method: Composition-based stats.
 Identities = 13/67 (19%), Positives = 25/67 (37%), Gaps = 3/67 (4%)

Query: 65  LNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQ 124
               G P  A   ++        +E+KS KLYL +F +    +   +   +  DL     
Sbjct: 40  CPITGQPDWATIRIDYRPGG-RGLETKSLKLYLETFREEGIFHEH-LATLIRDDLVAAL- 96

Query: 125 GKISVAL 131
             + + +
Sbjct: 97  APVQLTV 103


>UniRef50_B2KDU6 NADPH-dependent 7-cyano-7-deazaguanine reductase n=4 Tax=Bacteria
           RepID=QUEF_ELUMP
          Length = 132

 Score =  136 bits (343), Expect = 9e-31,   Method: Composition-based stats.
 Identities = 25/89 (28%), Positives = 43/89 (48%), Gaps = 2/89 (2%)

Query: 175 KVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRHHNEFHEQC 232
           +  +  +      S C  T  PD+G + I Y      ++ + L  YL+ +R    F E  
Sbjct: 33  RDYDIRIELPEFTSVCPKTGLPDFGVITIDYIPDRLCLELKSLKYYLLEYRDMGIFMENI 92

Query: 233 VERIFNDLLRFCQPEKLSVYARYTRRGGL 261
             +I +D+++ C+P+K  V   +T RGGL
Sbjct: 93  ANKILDDVVKACKPKKAVVTGDFTPRGGL 121


>UniRef50_B8HRW7 7-cyano-7-deazaguanine reductase n=2 Tax=Cyanobacteria
           RepID=B8HRW7_CYAP4
          Length = 142

 Score =  136 bits (342), Expect = 1e-30,   Method: Composition-based stats.
 Identities = 20/97 (20%), Positives = 41/97 (42%), Gaps = 2/97 (2%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHN 226
                 +     +        C  +  PD+ ++ + Y   Q  ++ + +  Y+ S+R   
Sbjct: 37  PNPRPGRRYTIQITLPEFTCKCPFSGYPDFATIHVSYIPDQRVVELKAIKLYINSYRDRY 96

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDI 263
             HE+ V +I +DL+  C P ++SV   +  RG +  
Sbjct: 97  ISHEESVNQILDDLVTACDPLQISVKGDFAPRGNVHT 133



 Score = 48.4 bits (114), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 22/103 (21%), Positives = 36/103 (34%), Gaps = 11/103 (10%)

Query: 28  SLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNL 87
             L   P         ++     F                 G P  A  HV        +
Sbjct: 31  GQLITFPNPRPGRRYTIQITLPEFTCK----------CPFSGYPDFATIHVSYIPD-QRV 79

Query: 88  IESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVA 130
           +E K+ KLY+NS+     ++ + V Q L+  ++ C   +ISV 
Sbjct: 80  VELKAIKLYINSYRDRYISHEESVNQILDDLVTACDPLQISVK 122


>UniRef50_A6Q0W4 NADPH-dependent 7-cyano-7-deazaguanine reductase n=6 Tax=Bacteria
           RepID=QUEF_NITSB
          Length = 131

 Score =  135 bits (341), Expect = 1e-30,   Method: Composition-based stats.
 Identities = 22/112 (19%), Positives = 45/112 (40%), Gaps = 2/112 (1%)

Query: 154 DITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--ID 211
           +  I  ++   D         K  +  +        C  +  PD+ ++ ++Y   Q  ++
Sbjct: 5   EKEIQEFDPKKDLEIWPNKHNKPYKIKITLPEFSCLCPRSGYPDYATMHLEYIPDQYVVE 64

Query: 212 REKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDI 263
            + L  Y+ SFR+    HE     IF+ L    +P+ + + A +  RG +  
Sbjct: 65  LKALKLYINSFRNRYISHEDSTNEIFDTLYSKLKPKYMRLVADFNPRGNVHT 116



 Score = 43.8 bits (102), Expect = 0.007,   Method: Composition-based stats.
 Identities = 19/58 (32%), Positives = 28/58 (48%), Gaps = 2/58 (3%)

Query: 58  TLYELSWLNAK-GLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQT 114
           TL E S L  + G P  A  H+E       ++E K+ KLY+NSF     ++ D   + 
Sbjct: 33  TLPEFSCLCPRSGYPDYATMHLEYIPD-QYVVELKALKLYINSFRNRYISHEDSTNEI 89


>UniRef50_B5IMF1 7-cyano-7-deazaguanine reductase n=1 Tax=Cyanobium sp. PCC 7001
           RepID=B5IMF1_9CHRO
          Length = 154

 Score =  133 bits (336), Expect = 5e-30,   Method: Composition-based stats.
 Identities = 25/109 (22%), Positives = 48/109 (44%), Gaps = 2/109 (1%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSFRHHN 226
                 +V E ++        C  +  PD+ +LQ+ Y+   R ++ + +  Y+ S+R   
Sbjct: 46  ENPRPGRVYEISITLPEFTCLCPFSGYPDFATLQLLYQPGPRVMELKAIKLYVNSYRDRT 105

Query: 227 EFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPS 275
             HE+ V R+ +D +  C P  + + A +  RG +      S+    PS
Sbjct: 106 ISHEEVVNRLLDDFVAACDPVWMQLEADFNPRGNVHTVIRASHGVRQPS 154



 Score = 41.5 bits (96), Expect = 0.034,   Method: Composition-based stats.
 Identities = 19/67 (28%), Positives = 28/67 (41%), Gaps = 3/67 (4%)

Query: 58  TLYELSWLNA-KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLE 116
           TL E + L    G P  A   +        ++E K+ KLY+NS+   R  + +EV   L 
Sbjct: 59  TLPEFTCLCPFSGYPDFATLQLLYQP-GPRVMELKAIKLYVNSYRD-RTISHEEVVNRLL 116

Query: 117 RDLSTCA 123
            D     
Sbjct: 117 DDFVAAC 123


>UniRef50_B0CDX9 NADPH-dependent 7-cyano-7-deazaguanine reductase n=40
           Tax=Cyanobacteria RepID=QUEF_ACAM1
          Length = 144

 Score =  133 bits (335), Expect = 6e-30,   Method: Composition-based stats.
 Identities = 20/101 (19%), Positives = 43/101 (42%), Gaps = 4/101 (3%)

Query: 167 LENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSF 222
           L         +  +  +        C  +  PD+ ++ + Y   Q  ++ + L  Y+ S+
Sbjct: 36  LITFPNPRVGRRYDIHITLPEFTCKCPFSGYPDFATIHLTYVPDQRVVELKALKLYINSY 95

Query: 223 RHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDI 263
           R     HE+ V +I +D++  C P +++V   +  RG +  
Sbjct: 96  RDRYISHEESVNQILDDIVAACDPLEITVKGDFLPRGNVHT 136



 Score = 48.4 bits (114), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 22/128 (17%), Positives = 41/128 (32%), Gaps = 16/128 (12%)

Query: 3   SYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYEL 62
           +  + Q  +    G+            L   P         +      F           
Sbjct: 14  NAQSVQETSESKYGE-----RQIAEGTLITFPNPRVGRRYDIHITLPEFTCK-------- 60

Query: 63  SWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTC 122
                 G P  A  H+        ++E K+ KLY+NS+     ++ + V Q L+  ++ C
Sbjct: 61  --CPFSGYPDFATIHLTYVPD-QRVVELKALKLYINSYRDRYISHEESVNQILDDIVAAC 117

Query: 123 AQGKISVA 130
              +I+V 
Sbjct: 118 DPLEITVK 125


>UniRef50_Q113I7 NADPH-dependent 7-cyano-7-deazaguanine reductase n=2
           Tax=Cyanobacteria RepID=QUEF_TRIEI
          Length = 141

 Score =  132 bits (331), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 20/102 (19%), Positives = 42/102 (41%), Gaps = 4/102 (3%)

Query: 167 LENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG--RQIDREKLLRYLVSF 222
           L         +  E  +        C  +  PD+ ++ I+Y    R ++ + +  Y+ S+
Sbjct: 31  LITFPNPRIGRRYEINISLPEFTCKCPFSGYPDFATIHIKYIPNERVVELKAIKLYINSY 90

Query: 223 RHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDIN 264
           R     HE+ V +I +D +  C P ++ +   +  RG +   
Sbjct: 91  RERYISHEESVNQILDDFVAACDPLEVKIKGDFLPRGNVHTT 132



 Score = 45.3 bits (106), Expect = 0.002,   Method: Composition-based stats.
 Identities = 21/101 (20%), Positives = 42/101 (41%), Gaps = 15/101 (14%)

Query: 31  QGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSW-LNAKGLPQVAVGHVELDYTSVNLIE 89
              PR   R  + +   +LP          E +      G P  A  H++       ++E
Sbjct: 34  FPNPRIGRRYEINI---SLP----------EFTCKCPFSGYPDFATIHIKYIPN-ERVVE 79

Query: 90  SKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVA 130
            K+ KLY+NS+ +   ++ + V Q L+  ++ C   ++ + 
Sbjct: 80  LKAIKLYINSYRERYISHEESVNQILDDFVAACDPLEVKIK 120


>UniRef50_C1CXM3 Putative GTP cyclohydrolase I n=2 Tax=Deinococcus deserti VCD115
           RepID=C1CXM3_DEIDV
          Length = 155

 Score =  131 bits (330), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 30/152 (19%), Positives = 60/152 (39%), Gaps = 7/152 (4%)

Query: 129 VALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKS 188
           +      +          G  +D  D+ + +        + A    + ++  +++     
Sbjct: 1   MTTTPPCQPGFDRRYDVQG--LDAIDVAVLDTFAYVRQDDPAAYPGEPMDIEIITDEFSP 58

Query: 189 NCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQP 246
            C  +  PD+G L+I+Y+ R   ++ + L  YL S+R    +HE    R+  DL +   P
Sbjct: 59  VCPWSGLPDFGRLEIRYQPREKCVELKSLKYYLTSYRFVGIYHEHATRRLLADLTQLLDP 118

Query: 247 EKLSVYARYTRRGGLDINPWRSNSDFVPSTTR 278
             +++   Y  RGGL+         +V    R
Sbjct: 119 LSMTIRCDYGMRGGLNT---VCTVRYVAPERR 147



 Score = 39.9 bits (92), Expect = 0.087,   Method: Composition-based stats.
 Identities = 18/88 (20%), Positives = 28/88 (31%), Gaps = 12/88 (13%)

Query: 34  PRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSF 93
           P +   +P+ ++     F     W           GLP      +         +E KS 
Sbjct: 39  PAAYPGEPMDIEIITDEFSPVCPW----------SGLPDFGRLEIRYQP-REKCVELKSL 87

Query: 94  KLYLNSFNQTRFNNWDEVRQTLERDLST 121
           K YL S+      +    R  L  DL+ 
Sbjct: 88  KYYLTSYRFVGIYHEHATR-RLLADLTQ 114


>UniRef50_B4U9Q5 7-cyano-7-deazaguanine reductase n=5 Tax=Bacteria
           RepID=B4U9Q5_HYDS0
          Length = 128

 Score =  130 bits (328), Expect = 4e-29,   Method: Composition-based stats.
 Identities = 28/126 (22%), Positives = 47/126 (37%), Gaps = 5/126 (3%)

Query: 153 QDITIDNYEFTTDYLENATCGEK--VVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR-- 208
           Q+      E     LE      K       +        C  +  PD+ +++I+Y     
Sbjct: 3   QEKKYGEIEIEKAALEPWENPAKENDYIIEMSFPEFSCLCPRSGYPDYATIKIRYIPNEY 62

Query: 209 QIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINP-WR 267
            ++ + L  +L SFR+    HE     I+N L    +P+ L V   +  RG L      R
Sbjct: 63  IVELKSLKLWLNSFRNQYISHEAATNTIYNKLFELLKPKFLEVIGDFHPRGNLHTVVRVR 122

Query: 268 SNSDFV 273
           S+  + 
Sbjct: 123 SDKKYD 128



 Score = 47.6 bits (112), Expect = 4e-04,   Method: Composition-based stats.
 Identities = 22/88 (25%), Positives = 33/88 (37%), Gaps = 12/88 (13%)

Query: 61  ELSWLNAK-GLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDL 119
           E S L  + G P  A   +        ++E KS KL+LNSF   ++ + +    T+   L
Sbjct: 37  EFSCLCPRSGYPDYATIKIRYIPN-EYIVELKSLKLWLNSFRN-QYISHEAATNTIYNKL 94

Query: 120 STCAQGKISVALYRLDELEGQPIGHFNG 147
                      L +   LE     H  G
Sbjct: 95  ---------FELLKPKFLEVIGDFHPRG 113


>UniRef50_B0KAC5 NADPH-dependent 7-cyano-7-deazaguanine reductase n=11
           Tax=Clostridia RepID=QUEF_THEP3
          Length = 133

 Score =  129 bits (325), Expect = 8e-29,   Method: Composition-based stats.
 Identities = 29/116 (25%), Positives = 50/116 (43%), Gaps = 12/116 (10%)

Query: 150 IDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ 209
           ID + +    YE+           EK      +++   S C  T  PD   L I+Y   +
Sbjct: 18  IDKEVLESIEYEY----------PEKNTIVEYITNEFSSVCPWTGLPDNAKLTIRYIPSK 67

Query: 210 --IDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDI 263
             ++ + L  YL S+R+     E  + RI +DL+   QP+ + +   +  RGG+  
Sbjct: 68  KLVELKSLKYYLTSYRNVGILQEHAINRILDDLVELLQPKFMEIIGEFQERGGIAT 123



 Score = 43.4 bits (101), Expect = 0.008,   Method: Composition-based stats.
 Identities = 21/84 (25%), Positives = 28/84 (33%), Gaps = 3/84 (3%)

Query: 61  ELSWLNA-KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDL 119
           E S +    GLP  A   +     S  L+E KS K YL S+          +   +  DL
Sbjct: 43  EFSSVCPWTGLPDNAKLTIRYIP-SKKLVELKSLKYYLTSYRNVGILQEHAI-NRILDDL 100

Query: 120 STCAQGKISVALYRLDELEGQPIG 143
               Q K    +    E  G    
Sbjct: 101 VELLQPKFMEIIGEFQERGGIATR 124


>UniRef50_B7JWF0 7-cyano-7-deazaguanine reductase n=8 Tax=Cyanobacteria
           RepID=B7JWF0_CYAP8
          Length = 142

 Score =  128 bits (323), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 17/101 (16%), Positives = 41/101 (40%), Gaps = 4/101 (3%)

Query: 167 LENATCG--EKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSF 222
           L         +  +  +        C  +  PD+ +L + Y   +  ++ + L  Y+  +
Sbjct: 31  LITFPNPRIGRRYDINITLPEFTCKCPFSGYPDFATLYLTYIPDEKVVELKALKLYINRY 90

Query: 223 RHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDI 263
           R     HE+ + +I +D +  C P ++++   +  RG +  
Sbjct: 91  RDRYISHEESINQILDDFVAACDPLEVTLKGDFNPRGNVHT 131



 Score = 41.9 bits (97), Expect = 0.024,   Method: Composition-based stats.
 Identities = 18/101 (17%), Positives = 39/101 (38%), Gaps = 15/101 (14%)

Query: 31  QGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSW-LNAKGLPQVAVGHVELDYTSVNLIE 89
              PR   R  + +    LP          E +      G P  A  ++        ++E
Sbjct: 34  FPNPRIGRRYDINIT---LP----------EFTCKCPFSGYPDFATLYLTYIPD-EKVVE 79

Query: 90  SKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVA 130
            K+ KLY+N +     ++ + + Q L+  ++ C   ++++ 
Sbjct: 80  LKALKLYINRYRDRYISHEESINQILDDFVAACDPLEVTLK 120


>UniRef50_Q5HS73 NADPH-dependent 7-cyano-7-deazaguanine reductase n=20 Tax=Bacteria
           RepID=QUEF_CAMJR
          Length = 127

 Score =  128 bits (322), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 22/117 (18%), Positives = 47/117 (40%), Gaps = 4/117 (3%)

Query: 161 EFTTDYLENATCGEK-VVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLR 217
           EF  + +E      K      +        C  +  PD+ ++ ++Y   +  ++ + +  
Sbjct: 10  EFDVENMEIWPNDAKNDYIIKITLPEFMCCCPRSGYPDFATIYLEYMPNKFVVELKAIKL 69

Query: 218 YLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDI-NPWRSNSDFV 273
           Y+ +F + N  HE  +  I+N L    +P+ + V   +  RG +      RS+    
Sbjct: 70  YINTFMYRNVSHEASINEIYNTLKDKLKPKWIKVVGDFNPRGNVHTVIECRSDMVVP 126


>UniRef50_A5IIZ4 NADPH-dependent 7-cyano-7-deazaguanine reductase n=7
           Tax=Thermotogaceae RepID=QUEF_THEP1
          Length = 137

 Score =  125 bits (315), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 27/104 (25%), Positives = 47/104 (45%), Gaps = 3/104 (2%)

Query: 164 TDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR---QIDREKLLRYLV 220
           TD+LE      K     + +    + C  +  PD G + I+Y       ++ + L  Y V
Sbjct: 19  TDFLEAIDFDGKDEYIKIETDEFSAVCPFSGLPDIGRVIIEYYPDGGKIVELKSLKYYFV 78

Query: 221 SFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDIN 264
           SFR+   + E+  +RI+ DL    + +++ V   Y  RGG+   
Sbjct: 79  SFRNVGIYQEEATKRIYEDLKNLLKTDRIRVTVIYNIRGGIKTT 122



 Score = 45.3 bits (106), Expect = 0.002,   Method: Composition-based stats.
 Identities = 18/84 (21%), Positives = 30/84 (35%), Gaps = 5/84 (5%)

Query: 47  DNLPFHGTDIW---TLYELSWLNA-KGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQ 102
           + + F G D +      E S +    GLP +    +E       ++E KS K Y  SF  
Sbjct: 23  EAIDFDGKDEYIKIETDEFSAVCPFSGLPDIGRVIIEYYPDGGKIVELKSLKYYFVSFRN 82

Query: 103 TRFNNWDEVRQTLERDLSTCAQGK 126
                 +  +  +  DL    +  
Sbjct: 83  VGIYQEEATK-RIYEDLKNLLKTD 105


>UniRef50_A8W229 ATP-dependent metalloprotease FtsH n=1 Tax=Bacillus
           selenitireducens MLS10 RepID=A8W229_9BACI
          Length = 135

 Score =  125 bits (315), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 27/109 (24%), Positives = 49/109 (44%), Gaps = 3/109 (2%)

Query: 159 NYEFTTDYLENATCGEKVVEET-LVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKL 215
           + E   + L +       V      +    + C  T QPD+G ++I+Y  R   I+ + L
Sbjct: 18  SVEEGRNVLRDEAFPAPDVSVVRFKALEFTAVCPKTGQPDFGQVEIEYVPRNKCIESKSL 77

Query: 216 LRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDIN 264
             YL S+R    + E    +I +D++   +P ++ V    T RGG+ + 
Sbjct: 78  KFYLWSYRDEGAYCESLAAQIADDVMAAIEPARVKVMVHQTPRGGIQLE 126



 Score = 50.7 bits (120), Expect = 5e-05,   Method: Composition-based stats.
 Identities = 22/106 (20%), Positives = 38/106 (35%), Gaps = 6/106 (5%)

Query: 32  GVPR----SLNRDPLGLKADNLPFHGTDIWTLYELSWLNAK-GLPQVAVGHVELDYTSVN 86
            +PR       R+ L  +A   P      +   E + +  K G P      +E    +  
Sbjct: 12  PMPRPASVEEGRNVLRDEAFPAPDVSVVRFKALEFTAVCPKTGQPDFGQVEIEYVPRN-K 70

Query: 87  LIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALY 132
            IESKS K YL S+            Q  +  ++     ++ V ++
Sbjct: 71  CIESKSLKFYLWSYRDEGAYCESLAAQIADDVMAAIEPARVKVMVH 116


>UniRef50_B5JRC9 7-cyano-7-deazaguanine reductase n=1 Tax=Verrucomicrobiae bacterium
           DG1235 RepID=B5JRC9_9BACT
          Length = 126

 Score =  125 bits (315), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 30/104 (28%), Positives = 49/104 (47%), Gaps = 2/104 (1%)

Query: 163 TTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLV 220
             D L+     E V   T+ S  L S+C IT QPD+ ++ I+Y  +   I+ + L  +L 
Sbjct: 13  PIDELDTFEAPEGVTTVTMTSDELTSSCPITGQPDFYNVSIEYAPKELCIESKSLKLFLW 72

Query: 221 SFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDIN 264
            FR    F E+    I + +++   P +  V      RGG++I 
Sbjct: 73  GFRDKAMFAEKIAAVICDRVVQDISPRRCRVMTFQKARGGIEIE 116


>UniRef50_B5IBP5 7-cyano-7-deazaguanine reductase n=2 Tax=Aciduliprofundum boonei
           T469 RepID=B5IBP5_9EURY
          Length = 135

 Score =  120 bits (302), Expect = 4e-26,   Method: Composition-based stats.
 Identities = 23/99 (23%), Positives = 40/99 (40%), Gaps = 2/99 (2%)

Query: 171 TCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEF 228
              E       +   L + C  T  PD+  L+I Y   +   + + L  YL+++R+   +
Sbjct: 12  EYPETKEVVEYIYPELTAVCPQTGLPDYYILRILYEPDKKLPELKSLKMYLIAYRNFGIW 71

Query: 229 HEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWR 267
           HE    +I +D     +P  + V      RGG+     R
Sbjct: 72  HEHLANKILDDFKSAVEPRWVYVELYVNNRGGIYTTVRR 110


>UniRef50_D0MDN3 7-cyano-7-deazaguanine reductase n=1 Tax=Rhodothermus marinus DSM
           4252 RepID=D0MDN3_RHOM4
          Length = 168

 Score =  105 bits (261), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 25/83 (30%), Positives = 39/83 (46%), Gaps = 3/83 (3%)

Query: 185 LLKSNCLITHQPDWGSLQIQYRGRQ--IDREKLLRYLVSFRHHNEFHEQCVERIFNDLLR 242
              + C  +  PD+G L+I+Y      ++ + L  Y+VS+R+     E     I+ DL+R
Sbjct: 76  EFSAVCPFSGLPDYGVLRIEYVPGSWILELKSLKYYIVSWRNIGAAQEDLTAIIYQDLMR 135

Query: 243 FC-QPEKLSVYARYTRRGGLDIN 264
               PE L V   Y  RGG+   
Sbjct: 136 HLEDPEYLRVITVYNVRGGIRTT 158


>UniRef50_Q9YBX9 Putative GTP cyclohydrolase I n=1 Tax=Aeropyrum pernix
           RepID=Q9YBX9_AERPE
          Length = 101

 Score = 76.5 bits (187), Expect = 9e-13,   Method: Composition-based stats.
 Identities = 19/67 (28%), Positives = 28/67 (41%), Gaps = 2/67 (2%)

Query: 188 SNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQ 245
           + C  T  PD   ++I+Y  R   ++   L  +L SFR      EQ    I   L    +
Sbjct: 8   AVCPFTGAPDSYDVEIEYVSRDACLEALSLASWLESFRGVKISQEQLAHEIALTLKELLK 67

Query: 246 PEKLSVY 252
           PE + V 
Sbjct: 68  PEYVCVK 74


>UniRef50_A2BLN0 Predicted GTP cyclohydrolase I n=1 Tax=Hyperthermus butylicus DSM
           5456 RepID=A2BLN0_HYPBU
          Length = 119

 Score = 73.5 bits (179), Expect = 8e-12,   Method: Composition-based stats.
 Identities = 17/93 (18%), Positives = 35/93 (37%), Gaps = 7/93 (7%)

Query: 169 NATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRG-------RQIDREKLLRYLVS 221
               GE  VE+ +++  +++ C +T   D   + ++Y+        R I+      YL S
Sbjct: 7   RVVEGEACVEKVVLTGSVEAVCPVTGMVDLYRVIVEYKPSSAGRVCRYIEALSFHFYLQS 66

Query: 222 FRHHNEFHEQCVERIFNDLLRFCQPEKLSVYAR 254
           ++      E+    I  D        ++ V   
Sbjct: 67  YKGRKILQEELTATIVRDFCEALGGGEVKVVTE 99


>UniRef50_B1YDZ8 GTP cyclohydrolase I n=5 Tax=Thermoproteaceae RepID=B1YDZ8_THENV
          Length = 114

 Score = 51.9 bits (123), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 16/91 (17%), Positives = 34/91 (37%), Gaps = 7/91 (7%)

Query: 188 SNCLITHQPDWGSLQIQYRGR--QIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQ 245
           + C I+   D   + ++Y  R   +  E+  R + S+R     HE+    +   +     
Sbjct: 24  AVCPISKVVDSFEVTVEYMPRGGALAIEEFKRMVDSYRGREILHEELAVDLMEKIKAAVN 83

Query: 246 PEKLSV--YARYTRRGGLDINPWRSNSDFVP 274
           P  + V   + Y    G+++     +    P
Sbjct: 84  PPYVKVVLKSVYI---GVEVEVVAESGGVPP 111


>UniRef50_B1SCE4 Putative uncharacterized protein n=1 Tax=Streptococcus infantarius
           subsp. infantarius ATCC BAA-102 RepID=B1SCE4_9STRE
          Length = 58

 Score = 44.6 bits (104), Expect = 0.004,   Method: Composition-based stats.
 Identities = 11/27 (40%), Positives = 18/27 (66%)

Query: 240 LLRFCQPEKLSVYARYTRRGGLDINPW 266
           ++   QP  L V+ ++T RGGL I+P+
Sbjct: 1   MIDLLQPRYLEVWGKFTPRGGLSIDPY 27


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.310    0.144    0.433 

Lambda     K      H
   0.267   0.0447    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,821,018,385
Number of Sequences: 3077464
Number of extensions: 81551764
Number of successful extensions: 177089
Number of sequences better than 1.0e-01: 73
Number of HSP's better than  0.1 without gapping: 179
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 176482
Number of HSP's gapped (non-prelim): 323
length of query: 282
length of database: 1,040,396,356
effective HSP length: 127
effective length of query: 155
effective length of database: 649,558,428
effective search space: 100681556340
effective search space used: 100681556340
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.1 bits)
S2: 92 (39.9 bits)
