Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	T	L	T	F	L	L	S	T	V	I	E	L	Y	T	M	V	L	L	L	R	I	W	M	Q	W	A	H	C	D	F	Y	N	P	F	S	Q	F	V	V	K	V	T	Q	P	I	I	G	P	L	R	R	V	I	P	A	M	G	P
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	D	S	A	S	L	L	V	A	Y	I	L	S	F	I	K	A	I	V	L	F	K	V	V	T	F	L	P	I	I	W	I	A	G	L	L	I	L	L	K	T	I	G	L	L	I	F	W	V	L	L	V	M	A	I	M	S	W	V	S
Secondary structure
SS confidence
Disorder																								?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Q	G	R	S	P	I	E	Y	V	L	I	Q	L	A	D	P	L	L	R	P	I	R	R	L	L	P	A	M	G	G	I	D	F	S	P	M	I	L	V	L	L	L	Y	V	I	N	M	G	V	A	E	V	L	Q	A	T	G	N	M	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.
Sequence		L	P	G	L	W	M	A	L
Secondary structure
SS confidence
Disorder			?	?	?		?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1izn chain A Region: 31 - 63 Aligned: 33 Modelled: 33 Confidence: 10.0% Identity: 21% Fold: Subunits of heterodimeric actin filament capping protein Capz Superfamily: Subunits of heterodimeric actin filament capping protein Capz Family: Capz alpha-1 subunit Phyre2 PDB 1vko chain A domain 1 Region: 140 - 154 Aligned: 15 Modelled: 15 Confidence: 7.5% Identity: 33% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 3rru chain A Region: 31 - 69 Aligned: 29 Modelled: 26 Confidence: 7.2% Identity: 17% PDB header:signaling protein Chain: A: PDB Molecule:tom1l1 protein; PDBTitle: x-ray crystal structure of the vhs domain of human tom1-like protein,2 northeast structural genomics consortium target hr3050e Phyre2 PDB 3lvw chain A Region: 9 - 38 Aligned: 29 Modelled: 30 Confidence: 6.5% Identity: 7% PDB header:ligase Chain: A: PDB Molecule:glutamate--cysteine ligase; PDBTitle: glutathione-inhibited scgcl Phyre2 PDB 1np7 chain A domain 1 Region: 33 - 62 Aligned: 28 Modelled: 30 Confidence: 6.4% Identity: 21% Fold: Cryptochrome/photolyase FAD-binding domain Superfamily: Cryptochrome/photolyase FAD-binding domain Family: Cryptochrome/photolyase FAD-binding domain Phyre2 PDB 1p1j chain A domain 1 Region: 140 - 155 Aligned: 16 Modelled: 16 Confidence: 5.7% Identity: 38% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 1 d1izna_ 2 d1vkoa1 3 c3rruA_ 4 c3lvwA_ 5 d1np7a1 6 d1p1ja1

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1izna_ 10.0 21 Fold:Subunits of heterodimeric actin filament capping protein Capz Superfamily:Subunits of heterodimeric actin filament capping protein Capz Family:Capz alpha-1 subunit 2 d1vkoa1 7.5 33 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain 3 c3rruA_ 7.2 17 PDB header:signaling protein Chain: A: PDB Molecule:tom1l1 protein; PDBTitle: x-ray crystal structure of the vhs domain of human tom1-like protein,2 northeast structural genomics consortium target hr3050e 4 c3lvwA_ 6.5 7 PDB header:ligase Chain: A: PDB Molecule:glutamate--cysteine ligase; PDBTitle: glutathione-inhibited scgcl 5 d1np7a1 6.4 21 Fold:Cryptochrome/photolyase FAD-binding domain Superfamily:Cryptochrome/photolyase FAD-binding domain Family:Cryptochrome/photolyase FAD-binding domain 6 d1p1ja1 5.7 38 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0