BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (159 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_B2K578 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 274 5e-73 UniRef50_Q1QU74 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 201 7e-51 UniRef50_Q487E8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 201 8e-51 UniRef50_D1PLD9 IspD/IspF enzyme n=2 Tax=Firmicutes RepID=D1PLD9... 195 3e-49 UniRef50_B8D9J7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 188 4e-47 UniRef50_D2RJ59 2C-methyl-D-erythritol 2,4-cyclodiphosphate synt... 186 3e-46 UniRef50_Q1LLZ4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 186 3e-46 UniRef50_Q18CD3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 185 5e-46 UniRef50_B0TYX5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 182 3e-45 UniRef50_C9KNS3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 178 5e-44 UniRef50_Q21YT7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 177 1e-43 UniRef50_C4Z3N3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 176 2e-43 UniRef50_C6LHN9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 174 6e-43 UniRef50_A9BVX5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 174 8e-43 UniRef50_Q6ARN9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 173 1e-42 UniRef50_C8PHW7 Bifunctional enzyme IspD/ispF n=1 Tax=Campylobac... 171 5e-42 UniRef50_B7H1F3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 171 9e-42 UniRef50_C4Z8W9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 169 3e-41 UniRef50_A9KSM7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 169 3e-41 UniRef50_A4WSL4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 168 6e-41 UniRef50_A0RN28 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 162 3e-39 UniRef50_Q30QG7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 158 5e-38 UniRef50_Q87DY3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 158 5e-38 UniRef50_Q1AU09 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 158 5e-38 UniRef50_Q2NAE1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 157 1e-37 UniRef50_Q0BTD5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 157 1e-37 UniRef50_Q5P993 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 157 2e-37 UniRef50_C6XJQ8 2C-methyl-D-erythritol 2,4-cyclodiphosphate synt... 156 2e-37 UniRef50_B6YRV8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 155 3e-37 UniRef50_UPI000197A0EE bifunctional 2-C-methyl-D-erythritol 4-ph... 154 8e-37 UniRef50_B2JA49 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 154 9e-37 UniRef50_Q1QM99 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 152 4e-36 UniRef50_C0R0Y4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 152 5e-36 UniRef50_UPI0001913A58 2-C-methyl-D-erythritol 2,4-cyclodiphosph... 151 8e-36 UniRef50_Q2IW23 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 150 1e-35 UniRef50_C9LKY7 IspD/IspF enzyme n=1 Tax=Dialister invisus DSM 1... 149 3e-35 UniRef50_Q7VFU3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 149 4e-35 UniRef50_Q2RFM1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 149 4e-35 UniRef50_B1GYT3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 148 5e-35 UniRef50_Q9CAK8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 148 7e-35 UniRef50_Q1QBM3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 147 8e-35 UniRef50_C3XLN9 Bifunctional enzyme ispD/ispF n=1 Tax=Helicobact... 147 1e-34 UniRef50_B6DX86 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 145 3e-34 UniRef50_A8LKV5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 145 3e-34 UniRef50_Q7MQW9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 145 4e-34 UniRef50_C1FJN6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 145 5e-34 UniRef50_C7GYL8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 145 6e-34 UniRef50_A5VQP4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 145 6e-34 UniRef50_A5V2U9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 143 2e-33 UniRef50_Q2GER2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 142 3e-33 UniRef50_Q2K8V5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 142 4e-33 UniRef50_C0QQE6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 142 4e-33 UniRef50_A6U8F8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 141 6e-33 UniRef50_C5EY67 Bifunctional enzyme ispD/ispF n=2 Tax=Helicobact... 140 2e-32 UniRef50_Q5GSM7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 138 5e-32 UniRef50_B1I0S9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 138 7e-32 UniRef50_Q4FM31 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 136 2e-31 UniRef50_B9JW91 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 136 3e-31 UniRef50_B8E112 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 135 4e-31 UniRef50_D1CCF0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 135 4e-31 UniRef50_Q310X3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 135 6e-31 UniRef50_Q9ZM19 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 135 6e-31 UniRef50_A7HDA2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 132 3e-30 UniRef50_Q0APQ6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 132 4e-30 UniRef50_C4XSW4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 132 5e-30 UniRef50_C3XI64 Bifunctional 2-C-methyl-D-erythritol 4-phosphate... 131 6e-30 UniRef50_Q1IVA8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 130 1e-29 UniRef50_D1B5E2 2C-methyl-D-erythritol 2,4-cyclodiphosphate synt... 130 1e-29 UniRef50_D1BMU2 2-C-methyl-D-erythritol 4-phosphate cytidylyltra... 130 1e-29 UniRef50_A3ZYT9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 129 3e-29 UniRef50_C1F762 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 129 4e-29 UniRef50_Q4MZY9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 128 5e-29 UniRef50_C6BS25 2-C-methyl-D-erythritol 4-phosphate cytidylyltra... 127 1e-28 UniRef50_B1Q2Q5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 127 1e-28 UniRef50_Q73KC6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 127 1e-28 UniRef50_B2URI3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 122 5e-27 UniRef50_B8CD73 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 121 7e-27 UniRef50_D0RP30 Bifunctional enzyme IspD/ispF n=1 Tax=alpha prot... 118 8e-26 UniRef50_B0SAT2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 117 1e-25 UniRef50_C4RE02 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 115 6e-25 UniRef50_B7FYU1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 115 6e-25 UniRef50_C8R0Y1 2-C-methyl-D-erythritol 4-phosphate cytidylyltra... 113 2e-24 UniRef50_A5CTY4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 112 5e-24 UniRef50_Q1MR76 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 111 7e-24 UniRef50_B2KDX1 2-C-methyl-D-erythritol 4-phosphate cytidylyltra... 109 2e-23 UniRef50_Q72HP8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 109 3e-23 UniRef50_B9KAZ0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 105 4e-22 UniRef50_B3L0R0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 105 4e-22 UniRef50_C7M1Q8 2-C-methyl-D-erythritol 4-phosphate cytidylyltra... 104 7e-22 UniRef50_B1L8F8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 103 2e-21 UniRef50_P62368 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 101 7e-21 UniRef50_B9RCH5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 100 2e-20 UniRef50_C1TMK1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 100 2e-20 UniRef50_B6KAQ3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 100 2e-20 UniRef50_C1CZ33 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 99 4e-20 UniRef50_B1VS88 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 98 9e-20 UniRef50_B1VIQ0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 97 1e-19 UniRef50_C5CGG7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 95 7e-19 UniRef50_C9M692 2-C-methyl-D-erythritol 4-phosphate cytidylyltra... 95 9e-19 UniRef50_Q7NC56 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 94 1e-18 UniRef50_Q14PQ0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 94 2e-18 UniRef50_A9BHL8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 89 3e-17 UniRef50_B4U9N6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 87 2e-16 UniRef50_A8F4L5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 85 6e-16 UniRef50_Q8EUA4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 84 1e-15 UniRef50_Q83NK3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 80 2e-14 UniRef50_B0BC71 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 78 8e-14 UniRef50_A7AVQ2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 78 1e-13 UniRef50_A6LJL2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 74 1e-12 UniRef50_B5Y8V5 Bifunctional enzyme IspD/ispF n=1 Tax=Coprotherm... 73 3e-12 UniRef50_B8I5R3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 73 3e-12 UniRef50_Q0PH58 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 72 8e-12 UniRef50_C2BUI0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 69 4e-11 UniRef50_B7GT04 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 69 4e-11 UniRef50_C5BMS2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 69 5e-11 UniRef50_B7IFV0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 66 4e-10 UniRef50_A7HN63 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 65 6e-10 UniRef50_UPI0001B44793 2-C-methyl-D-erythritol 2,4-cyclodiphosph... 62 5e-09 UniRef50_Q0PH60 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 57 2e-07 >UniRef50_B2K578 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=32 Tax=Bacteria RepID=ISPF_YERPB Length = 162 Score = 274 bits (701), Expect = 5e-73, Method: Compositional matrix adjust. Identities = 136/161 (84%), Positives = 145/161 (90%), Gaps = 2/161 (1%) Query: 1 MRIGHGFDVHAFG--GEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIG 58 MRIGHGFDVH FG G GP+IIGGVRIPYEKGLLAHSDGDVALHA TDALLGAAALGDIG Sbjct: 1 MRIGHGFDVHKFGENGSGPLIIGGVRIPYEKGLLAHSDGDVALHAATDALLGAAALGDIG 60 Query: 59 KLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAE 118 KLFPDTDPAFKGADSR LLREA+R I AKGY LGN+D+TIIAQAPKM PHIPQMRV +AE Sbjct: 61 KLFPDTDPAFKGADSRGLLREAYRCILAKGYKLGNLDITIIAQAPKMAPHIPQMRVNLAE 120 Query: 119 DLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 DL CHMDD+NVKATTTE+LGFTGRGEGIACEAV LL+ + Sbjct: 121 DLQCHMDDINVKATTTEQLGFTGRGEGIACEAVVLLVNVEQ 161 >UniRef50_Q1QU74 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=14 Tax=Bacteria RepID=ISPF_CHRSD Length = 162 Score = 201 bits (510), Expect = 7e-51, Method: Compositional matrix adjust. Identities = 101/155 (65%), Positives = 118/155 (76%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIGHGFDVH FG ++IGGVRIPY +G +AHSDGDV LHA+ DALLGA ALGDIG+ Sbjct: 3 LRIGHGFDVHRFGDGDHLMIGGVRIPYVQGFVAHSDGDVLLHAICDALLGACALGDIGRH 62 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD A+ GADSR+LLR + A GY + N+D T+IAQAP+M HIP MR IAEDL Sbjct: 63 FPDTDAAWAGADSRDLLRHVHTLVMAAGYAVANLDATVIAQAPRMAEHIPAMRACIAEDL 122 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 VNVKATT+E+LGFTGR EGIA EAV LL+ Sbjct: 123 DLDTTAVNVKATTSERLGFTGRKEGIAAEAVVLLM 157 >UniRef50_Q487E8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=49 Tax=Bacteria RepID=ISPF_COLP3 Length = 170 Score = 201 bits (510), Expect = 8e-51, Method: Compositional matrix adjust. Identities = 96/155 (61%), Positives = 118/155 (76%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIGHGFDVH FGG+GP+++GGV+IP+E G +AHSDGDVA+HAL DA+LGA L DIG Sbjct: 1 MRIGHGFDVHKFGGKGPLVLGGVKIPFELGFIAHSDGDVAIHALCDAILGALCLADIGNH 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD ++ SR LLR + KG+ LGN D+TI+AQAPKM PH+ MR ++EDL Sbjct: 61 FPDTDGQYENISSRILLRHVVSLMTDKGFQLGNADITIVAQAPKMAPHLVAMRTCLSEDL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 ++ VNVKATTTEKLG+TGR EGI+ AV LLI Sbjct: 121 KTTIEQVNVKATTTEKLGYTGRKEGISVHAVVLLI 155 >UniRef50_D1PLD9 IspD/IspF enzyme n=2 Tax=Firmicutes RepID=D1PLD9_9FIRM Length = 400 Score = 195 bits (496), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 97/154 (62%), Positives = 114/154 (74%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIGHG+DVH +I+GGV IPYEKGLL HSD DV LHA+ DA+LGAAALGDIGK Sbjct: 245 MRIGHGYDVHQLVEGRKLILGGVEIPYEKGLLGHSDADVLLHAIMDAVLGAAALGDIGKH 304 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTDPA+KGADS L R ++ +GY++GN+D TI+ QAPK+ PHIP MR IAE Sbjct: 305 FPDTDPAYKGADSLALTRAVAGLVREQGYSVGNIDSTILCQAPKLAPHIPAMRAHIAEAF 364 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 G +D V+VKATT E +GFTG G GIA AV LL Sbjct: 365 GIPLDAVSVKATTEEHMGFTGEGRGIAAHAVVLL 398 >UniRef50_B8D9J7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=55 Tax=Gammaproteobacteria RepID=ISPF_BUCA5 Length = 161 Score = 188 bits (478), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 84/159 (52%), Positives = 117/159 (73%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIG+GFD+HAFG P+IIGGV IP EKGL+AHS+GD+ +H+L DALLGA A+GDIG Sbjct: 1 MRIGYGFDLHAFGSTKPLIIGGVLIPCEKGLIAHSNGDLLIHSLIDALLGATAMGDIGSF 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP + +K DSR LL++ W +I Y + N+D+TIIA+ PKMLP+I MR ++ DL Sbjct: 61 FPSNNYIYKNIDSRILLKKIWNKIILLNYDICNIDITIIAEYPKMLPYIFFMRSNLSLDL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 +D++++K+TT++K+G GR E IAC ++ +LIK K Sbjct: 121 NTEIDNISIKSTTSKKIGCIGRKEAIACHSIVMLIKNKK 159 >UniRef50_D2RJ59 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RJ59_ACIFE Length = 395 Score = 186 bits (471), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 95/156 (60%), Positives = 115/156 (73%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 RIG G+DVH P+I+ GV +P+++GL HSD DVALHAL DALLGAA +GDIG+L Sbjct: 240 FRIGSGYDVHRLVEGRPLILCGVTVPWDRGLDGHSDADVALHALMDALLGAAGMGDIGRL 299 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD A+ GADSR+LL +++A G+ + NVDVTIIAQ PK+ P+ P M + DL Sbjct: 300 FPDTDDAYLGADSRKLLAAVLEKLRAAGWQVNNVDVTIIAQRPKLAPYEPAMLENLLTDL 359 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 G D VNVKATTTEKLGFTGRGEGIA EAVA L + Sbjct: 360 GLPRDAVNVKATTTEKLGFTGRGEGIAAEAVASLTR 395 >UniRef50_Q1LLZ4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=60 Tax=Bacteria RepID=ISPF_RALME Length = 168 Score = 186 bits (471), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 93/156 (59%), Positives = 113/156 (72%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIG G+DVHA +I+GGV IP+++GLL HSD D LHA+TDAL GAAALGDIG+ Sbjct: 6 IRIGQGYDVHALVPGRKLILGGVDIPHDRGLLGHSDADALLHAVTDALFGAAALGDIGRH 65 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTDP F GADSR LLREA RR++ GY +GNVD T+IAQ PK+ PHI M +AEDL Sbjct: 66 FPDTDPNFAGADSRVLLREAVRRVREAGYEIGNVDATVIAQKPKLAPHISGMVANLAEDL 125 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 G + NVKA T EKLGF G+ EGI +A L+ + Sbjct: 126 GLPVTRCNVKAKTNEKLGFEGKEEGIVAQAAVLIYR 161 >UniRef50_Q18CD3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=116 Tax=Bacteria RepID=ISPF_CLOD6 Length = 161 Score = 185 bits (469), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 87/159 (54%), Positives = 117/159 (73%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIG G+DVH + +IIGGV IP++KGLL HSD DV +HA+ D++LGA ALGDIGK Sbjct: 1 MRIGLGYDVHKLTEDRKLIIGGVEIPHDKGLLGHSDADVLIHAIMDSILGALALGDIGKH 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD +KGADS +LL + I +KGY +GN+D TIIAQ+PKM P+I MR I++ L Sbjct: 61 FPDTDEEYKGADSMKLLEHVYNLITSKGYKIGNIDSTIIAQSPKMAPYIESMRSNISKVL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 +D++N+KATT E LGFTG +GIA +++ LL+ ++ Sbjct: 121 NTDIDNINIKATTEEGLGFTGAKQGIASQSICLLLLTSQ 159 >UniRef50_B0TYX5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=5 Tax=Gammaproteobacteria RepID=ISPF_FRAP2 Length = 159 Score = 182 bits (463), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 89/155 (57%), Positives = 110/155 (70%), Gaps = 1/155 (0%) Query: 1 MRIGHGFDVHAFGG-EGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGK 59 RIGHG+DVH F + II+GG+ IPYE GL AHSDGDV +HAL DA+LGA LGDIGK Sbjct: 3 FRIGHGYDVHKFTSTKKNIILGGIEIPYEMGLEAHSDGDVLIHALCDAILGALCLGDIGK 62 Query: 60 LFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAED 119 FPDTD +K DS+ L E + + K Y++ N+D TIIAQAPKMLPHI +M+ +A Sbjct: 63 HFPDTDMEYKNTDSKFFLAEIKKMLDDKEYSISNIDCTIIAQAPKMLPHIEKMKACLASV 122 Query: 120 LGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 L ++ +N+KATTTE+LGF GR EGIA V LL Sbjct: 123 LEIQINQINIKATTTEQLGFIGRKEGIATHVVCLL 157 >UniRef50_C9KNS3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KNS3_9FIRM Length = 158 Score = 178 bits (452), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 93/151 (61%), Positives = 109/151 (72%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 R G G+DVH +IIGGV IP+ GLL HSD DV LHA++DALLGAAALGDIG+ F Sbjct: 3 RFGMGYDVHRLVEGRKLIIGGVEIPHALGLLGHSDADVLLHAISDALLGAAALGDIGRHF 62 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 PDTDP ++GADS +LL E R + KGY +GNVD TI+AQ PKM IP+M IA LG Sbjct: 63 PDTDPRYEGADSMKLLAEVRRLLAEKGYRIGNVDATIVAQKPKMKDFIPKMNENIATVLG 122 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVA 152 +DDVNVKATT EKLGFTG +GI+ AVA Sbjct: 123 VSLDDVNVKATTEEKLGFTGAEQGISAYAVA 153 >UniRef50_Q21YT7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=175 Tax=Bacteria RepID=ISPDF_RHOFD Length = 418 Score = 177 bits (448), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 91/156 (58%), Positives = 110/156 (70%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 RIG G+D+HA +++GGV IPY GLL HSD DV LHA+TDALLGAAALGDIG Sbjct: 261 FRIGEGWDIHALVAGRKLLLGGVEIPYHLGLLGHSDADVLLHAITDALLGAAALGDIGTH 320 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD FKGADS LL EA RR++AKG+ +GNVD T+IAQAPK++P++ MR IA L Sbjct: 321 FPDTDARFKGADSLVLLTEAARRVRAKGFEIGNVDSTVIAQAPKLMPYMAAMRAQIALAL 380 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 +D VNVKA T EK+G G G+ + A LL K Sbjct: 381 ALEVDQVNVKAKTAEKMGPVGLGQAMEARATVLLRK 416 >UniRef50_C4Z3N3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=426 Tax=cellular organisms RepID=ISPF_EUBE2 Length = 183 Score = 176 bits (447), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 90/154 (58%), Positives = 108/154 (70%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MR+G G+DVH + +I+GGV IPYE GLL HSD DV LHA+ DALLGAAALGDIGK Sbjct: 1 MRVGMGYDVHKLVKDRKLIMGGVEIPYELGLLGHSDADVLLHAIMDALLGAAALGDIGKH 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD +KG S +LL E ++I Y + N+D TIIAQ PKM P+I MR IA+ L Sbjct: 61 FPDTDDRYKGISSIKLLEEVGKKIDEANYIIENIDATIIAQKPKMRPYIDDMRKNIADAL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 +D VNVKATT E LGFTG GEGI+ +A+ L Sbjct: 121 KIDVDRVNVKATTEEGLGFTGSGEGISSQAICSL 154 >UniRef50_C6LHN9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Bryantella formatexigens DSM 14469 RepID=C6LHN9_9FIRM Length = 226 Score = 174 bits (442), Expect = 6e-43, Method: Compositional matrix adjust. Identities = 87/155 (56%), Positives = 109/155 (70%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MR+G G+DVH +I+ GV IPYEKGLL HSD DVA+HA+ DALLGAAALGDIGK Sbjct: 40 MRVGMGYDVHRLTEGRKLILCGVEIPYEKGLLGHSDADVAVHAIMDALLGAAALGDIGKH 99 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD + G S LL+ ++ Y + N+D TIIAQ PK+LP++PQM +AE L Sbjct: 100 FPDTDAQYAGISSILLLKRVGDLLEENNYIIENIDATIIAQRPKLLPYMPQMVKNVAEAL 159 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 G + VN+KATT E LGFTG GEGI+ +A+ LL+ Sbjct: 160 GIEENQVNIKATTEEGLGFTGNGEGISAQAICLLM 194 >UniRef50_A9BVX5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Bacteria RepID=A9BVX5_DELAS Length = 162 Score = 174 bits (441), Expect = 8e-43, Method: Compositional matrix adjust. Identities = 89/146 (60%), Positives = 107/146 (73%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 RIG G+DVHA +I+GG+ +P+E GLL HSD DV LHA+TDALLG AALGDIG+ Sbjct: 6 FRIGEGWDVHALVPGRKLILGGIEVPHELGLLGHSDADVLLHAITDALLGGAALGDIGRH 65 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTDP F+GADS LL EA RR++A G +GN+D TIIAQAPK+ PHIP MR IA L Sbjct: 66 FPDTDPEFRGADSLVLLVEAARRVRATGLEIGNIDSTIIAQAPKLAPHIPAMRERIATAL 125 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGI 146 G +D VNVKA T EKLG G+ + + Sbjct: 126 GLALDQVNVKAKTAEKLGPVGQQQAM 151 >UniRef50_Q6ARN9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=4 Tax=Proteobacteria RepID=ISPDF_DESPS Length = 386 Score = 173 bits (439), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 81/154 (52%), Positives = 105/154 (68%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIGHGFD H + +I+GGV IPY GL HSD DV +HAL DALLGA GDIG+ Sbjct: 231 IRIGHGFDAHQLVEKRRLILGGVEIPYHLGLAGHSDADVLVHALCDALLGAIGAGDIGRH 290 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPD+ AFK S LL +++ Y +GN D+++I QAPK+ P++ QM+ IA Sbjct: 291 FPDSSDAFKDIYSIRLLESVMQKVGELNYKIGNADISVICQAPKLAPYLKQMQEIIATSC 350 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 C + D+N+KATTTEK+G+TGRGEGI+C AV LL Sbjct: 351 ACQISDINIKATTTEKMGYTGRGEGISCHAVVLL 384 >UniRef50_C8PHW7 Bifunctional enzyme IspD/ispF n=1 Tax=Campylobacter gracilis RM3268 RepID=C8PHW7_9PROT Length = 440 Score = 171 bits (434), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 89/151 (58%), Positives = 109/151 (72%), Gaps = 2/151 (1%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G G+DVHA I++GGV+IP E L+AHSDGDVA+HAL DA+ GAA LGDIG+LFPD Sbjct: 277 GTGYDVHALEKGAGIMLGGVQIPCEFALIAHSDGDVAIHALIDAICGAAMLGDIGELFPD 336 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCH 123 +D KGADS+ELLR+ RR++ GY L N D+TIIAQ PK+ + QM+ ++E L C Sbjct: 337 SDAKLKGADSKELLRKVMRRVRGYGYELVNADITIIAQRPKIGAYKAQMQKVLSEILNCA 396 Query: 124 MDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 VNVKATTTE LGFTGR EGIA +A L Sbjct: 397 R--VNVKATTTEGLGFTGRSEGIAAQAAVSL 425 >UniRef50_B7H1F3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=15 Tax=Bacteria RepID=ISPF_ACIB3 Length = 160 Score = 171 bits (432), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 85/154 (55%), Positives = 108/154 (70%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIG G DVHAF + + GV+IP+ GL AHSDGDV LHAL DALLGA ALGDIG+ Sbjct: 5 IRIGQGMDVHAFEEGNFVTLAGVQIPHTHGLKAHSDGDVVLHALCDALLGALALGDIGQH 64 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTDP FKGADSR LL+ ++ I +GY L N D+T+ + PK+ + +MR IA+ L Sbjct: 65 FPDTDPEFKGADSRVLLKHVYQLILDRGYHLNNADITVACERPKLAKYNLEMRQSIADVL 124 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 ++ +++KATTTEKLGFTGR EGI A L+ Sbjct: 125 NVDLNQISIKATTTEKLGFTGRQEGILATATVLI 158 >UniRef50_C4Z8W9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=38 Tax=cellular organisms RepID=ISPF_EUBR3 Length = 177 Score = 169 bits (428), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 85/154 (55%), Positives = 107/154 (69%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MR+G G+DVH +I+GGV++P+ GLL HSD DV LHA+ DALLGAAALGDIGK Sbjct: 1 MRVGMGYDVHKLVEGRDLILGGVKVPHTLGLLGHSDADVLLHAIMDALLGAAALGDIGKH 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTDPA++G S +LL I KGY + N+D T+IAQ PK+ P+I QM +A+ L Sbjct: 61 FPDTDPAYEGISSLKLLEHVRDLIAKKGYVIENIDATVIAQKPKLRPYIEQMEQNVADTL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 + VN+KATT E LGFTGR EGIA +A+ L Sbjct: 121 QIAKEQVNIKATTEEWLGFTGREEGIASQAICSL 154 >UniRef50_A9KSM7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=5 Tax=Bacteria RepID=A9KSM7_CLOPH Length = 192 Score = 169 bits (428), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 86/154 (55%), Positives = 106/154 (68%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIG G+DVH +IIGGV +PYEKGLL HSD DV +HA+ DA+LGAAALGDIGK Sbjct: 1 MRIGMGYDVHKLVEGRDLIIGGVTVPYEKGLLGHSDADVLVHAIMDAILGAAALGDIGKH 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDT ++G S LL + ++ + Y +GN+D TIIAQ PKM +IPQM IA+ L Sbjct: 61 FPDTSKEYEGVSSIVLLEKVKELVEKECYIIGNIDATIIAQRPKMAQYIPQMVTNIAKTL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 VNVKATT E LGFTG G+GI+ +A+ LL Sbjct: 121 HISEKQVNVKATTEEGLGFTGSGDGISAQAICLL 154 >UniRef50_A4WSL4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=6 Tax=Rhodobacterales RepID=ISPF_RHOS5 Length = 159 Score = 168 bits (425), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 86/157 (54%), Positives = 111/157 (70%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G+GFDVHAFG + + GVR+P+ +GL+ HSD DV +HALTDA+ GA A GDIG Sbjct: 3 IRTGNGFDVHAFGPGDHVWLCGVRVPHHRGLIGHSDADVGMHALTDAIYGALAEGDIGVH 62 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA SR L A RI A+G+TL N DVT+I + PK+ P P MR +A + Sbjct: 63 FPPSDPQWKGAASRIFLEHAMGRIAARGFTLANCDVTLICERPKIGPMAPAMREALAAIM 122 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 G + ++VKATT+EKLGFTGR EGIAC A A L++A Sbjct: 123 GVEVGRISVKATTSEKLGFTGREEGIACIATATLLQA 159 >UniRef50_A0RN28 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=19 Tax=Campylobacter RepID=ISPDF_CAMFF Length = 372 Score = 162 bits (411), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 82/151 (54%), Positives = 105/151 (69%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G+GFDVHAF I + GV+IPY K +AHSDGDVALHAL DALLGAA+ DIG+L+PD Sbjct: 213 GNGFDVHAFKEGDFITLCGVKIPYSKAFIAHSDGDVALHALCDALLGAASAPDIGELYPD 272 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCH 123 D FK DS+ LL+ + I++ G+ + N D+TIIAQ+PK+ P+ M +A+ LG Sbjct: 273 NDSKFKDIDSKILLQNSVNLIRSIGFDIINADITIIAQSPKISPYKDAMAKIVADILGIP 332 Query: 124 MDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 + VN+KATTTE LGF GR EGIA A+ L Sbjct: 333 LHKVNIKATTTEHLGFIGRNEGIAANAIVNL 363 >UniRef50_Q30QG7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=11 Tax=Epsilonproteobacteria RepID=ISPDF_SULDN Length = 386 Score = 158 bits (400), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 82/151 (54%), Positives = 105/151 (69%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G GFDVHAF +G + +GG++I E G LAHSDGDVA+HAL DALLGAA +GDIG +FPD Sbjct: 228 GVGFDVHAFDDKGEMFLGGIKIDSEYGFLAHSDGDVAIHALIDALLGAAGMGDIGMMFPD 287 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCH 123 D +KGADS+ELL +++ G+ + NVD+TI A+ P++ + MR I+ LG Sbjct: 288 NDVKYKGADSKELLGTLVTKLRHFGFVIVNVDITIAAEKPRIGNYKMAMRKKISSILGID 347 Query: 124 MDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 VN+KATTTEKLGF GRGEG+ A A L Sbjct: 348 AQRVNIKATTTEKLGFIGRGEGVGVIANANL 378 >UniRef50_Q87DY3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=9 Tax=Xylella fastidiosa RepID=ISPF_XYLFT Length = 176 Score = 158 bits (400), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 80/156 (51%), Positives = 109/156 (69%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIG G+DVHAFG +++GGVR+P+ G+LAHSDGDV LHAL DA+LGA LGDIG+ Sbjct: 15 VRIGQGYDVHAFGPSDHVMLGGVRVPHRCGVLAHSDGDVILHALCDAMLGALGLGDIGQH 74 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +D +KGADS +R ++ + + +GNVD T I ++PK+ P++ MR IA L Sbjct: 75 FPPSDVRWKGADSGVFVRHCNLLLRERDWCVGNVDATAICESPKIAPYVNAMREGIARLL 134 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 + V+VKATT+E LGF GRGEG+A + V LL + Sbjct: 135 EVQPECVSVKATTSEGLGFIGRGEGLAAQVVVLLYR 170 >UniRef50_Q1AU09 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=6 Tax=Bacteria RepID=ISPF_RUBXD Length = 165 Score = 158 bits (399), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 88/160 (55%), Positives = 109/160 (68%), Gaps = 4/160 (2%) Query: 2 RIGHGFDVHAFG--GEG-PIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIG 58 R+G G DVHAF EG +++GGVRIP E+GL HSD DV HA+TDALLGAA L DIG Sbjct: 5 RVGLGVDVHAFADPAEGRQLVLGGVRIPSERGLRGHSDADVLAHAVTDALLGAAGLEDIG 64 Query: 59 KLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAE 118 FPDTD F+ ADS LLREA RRI G+ + NVD +I + P++ H +MR +A Sbjct: 65 HYFPDTDERFRDADSIWLLREA-RRIVGGGWEVVNVDAVVICERPRIREHREKMRENLAA 123 Query: 119 DLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 LG V+V+ TT+E+LGFTGRGEGIA +AV LL +A Sbjct: 124 ALGVEASRVSVRGTTSERLGFTGRGEGIAAQAVCLLERAV 163 >UniRef50_Q2NAE1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=7 Tax=Bacteria RepID=ISPDF_ERYLH Length = 386 Score = 157 bits (397), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 80/156 (51%), Positives = 106/156 (67%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R+G GFDVH + +GG+R+ ++KGL HSD DVALHA+ DALLGA GDIG Sbjct: 226 VRVGTGFDVHKLEAGEELWLGGIRLEHDKGLAGHSDADVALHAIVDALLGAIGKGDIGDH 285 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA S + A + + GY +GN+D+TII +AP++ PH M IAE L Sbjct: 286 FPPSDPQWKGAASSAFIEHAAKLVDEAGYRVGNIDLTIICEAPRIGPHRDAMGQRIAELL 345 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 D ++VKATTTEKLGFTGRGEGIA +A A +++ Sbjct: 346 ATSPDAISVKATTTEKLGFTGRGEGIAAQAAATVVR 381 >UniRef50_Q0BTD5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Alphaproteobacteria RepID=ISPDF_GRABC Length = 376 Score = 157 bits (397), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 79/154 (51%), Positives = 106/154 (68%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 RIG G+DVHAF +I+ G+ +P+ +GL HSD DV +HAL DA+ GA A GDIG+ F Sbjct: 220 RIGTGYDVHAFETGRKLILCGIEVPHHQGLAGHSDADVGIHALCDAIYGALAEGDIGRHF 279 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 P T+ ++K ADS LR A RI A+G L N D+T+I + PK+ PH P M +AE LG Sbjct: 280 PPTEASWKDADSARFLRHAAERIAARGGFLANADLTLICEKPKITPHAPAMIARLAELLG 339 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 +D ++VKATT+EKLGFTGR EGIA +A +++ Sbjct: 340 VSIDKISVKATTSEKLGFTGREEGIAAQAAVIIM 373 >UniRef50_Q5P993 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=7 Tax=Anaplasmataceae RepID=ISPF_ANAMM Length = 184 Score = 157 bits (396), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 78/162 (48%), Positives = 105/162 (64%), Gaps = 4/162 (2%) Query: 1 MRIGHGFDVHAFGGEGP----IIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGD 56 R+G G+DVH F P I++ GV I + + + AHSDGDV HAL DALLG G Sbjct: 10 FRVGIGYDVHGFADSPPENGHIVLCGVEIAFHRKIKAHSDGDVGTHALVDALLGCVGEGS 69 Query: 57 IGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFI 116 IG+ FP+TDP ++ S L EA + AKGY + N D+TI+ + PK++PH+P+M++F+ Sbjct: 70 IGEHFPNTDPRWENMSSTHFLLEAQSKALAKGYAVLNFDLTIVCELPKIIPHVPKMKLFM 129 Query: 117 AEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 ++ LG +N+KA TTEKLGF GRGEGIA AV L K T Sbjct: 130 SKLLGMDASAINIKAVTTEKLGFIGRGEGIAAHAVVLCRKVT 171 >UniRef50_C6XJQ8 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XJQ8_HIRBI Length = 387 Score = 156 bits (394), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 80/156 (51%), Positives = 104/156 (66%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 RIG+G+DVHAF + + G+ IP+ L HSD DVA HALTDA+ GA A GDIG F Sbjct: 231 RIGNGYDVHAFEDGQSVTLCGLEIPHSASLKGHSDADVAWHALTDAIYGALAEGDIGTHF 290 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 P +D +KGA S+ L+ A +KG+ + N D+TII +APK+ PH MR ++ LG Sbjct: 291 PPSDVKWKGAASKVFLKHAVELADSKGFMIANADITIICEAPKIKPHSMTMRDITSKILG 350 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 +D V+VKATTTEKLGFTGR EGIA +A LL+ + Sbjct: 351 IPLDRVSVKATTTEKLGFTGRKEGIAAQASVLLVSS 386 >UniRef50_B6YRV8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=4 Tax=Bacteroidales RepID=ISPF_AZOPC Length = 167 Score = 155 bits (393), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 73/154 (47%), Positives = 103/154 (66%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIG G+DVH + +GG++IPYEKGL HSD DV +HAL DALLGAA +G+IG Sbjct: 3 IRIGFGYDVHPLVMNYNLWLGGIKIPYEKGLKGHSDADVLIHALCDALLGAADIGNIGTN 62 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP+T+ + DS+ LL++ I +K Y L N D+T+ + PK+ P IPQM+ +AE + Sbjct: 63 FPNTNKKLRNIDSKILLKQTMSFIYSKNYELNNADITVCIEQPKLNPFIPQMKTCLAEIM 122 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 ++++KATT+EK+GF GR EGIA A L+ Sbjct: 123 QTDKGNISIKATTSEKMGFIGREEGIAVFATVLI 156 >UniRef50_UPI000197A0EE bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein n=1 Tax=Helicobacter cinaedi CCUG 18818 RepID=UPI000197A0EE Length = 401 Score = 154 bits (389), Expect = 8e-37, Method: Compositional matrix adjust. Identities = 76/148 (51%), Positives = 102/148 (68%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 +G+G DVH+F + +GGV+I G AHSDGDVALHAL+DA+LGA GDIG+ FP Sbjct: 227 VGNGIDVHSFEDNKEMWLGGVKIESSFGFKAHSDGDVALHALSDAILGAIGGGDIGQWFP 286 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 D++ A+K ADS++LL+ + + + GY L NVD++I+AQ PK+ P+ QMR IA L Sbjct: 287 DSNEAYKNADSKKLLQHIYDFVLSVGYELHNVDISIMAQTPKIAPYKSQMRECIARILHL 346 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEA 150 VN+KATTTE LGF GR EG+ +A Sbjct: 347 PKSRVNIKATTTESLGFVGRKEGVCVQA 374 >UniRef50_B2JA49 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=7 Tax=Bacteria RepID=ISPF_NOSP7 Length = 160 Score = 154 bits (389), Expect = 9e-37, Method: Compositional matrix adjust. Identities = 75/156 (48%), Positives = 106/156 (67%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIG+G+D+H + +I+GG++IP+E GLL HSD DV HA+ DA+LGA +LGDIG Sbjct: 4 IRIGNGYDIHQLVSDRVLILGGIQIPHELGLLGHSDADVLTHAIMDAMLGALSLGDIGHY 63 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP + GADS LL + + I+ +G+ +GN+D ++A+ PK+ PHI MR +A L Sbjct: 64 FPPSDPKWAGADSLVLLNQVHQLIRDRGWQVGNIDSVVVAERPKLKPHIHNMRDKLAAIL 123 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 + + +KATT EKLG GR EGI AV LL+K Sbjct: 124 ELESNQIGIKATTNEKLGPVGREEGICAYAVVLLLK 159 >UniRef50_Q1QM99 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=37 Tax=Alphaproteobacteria RepID=ISPDF_NITHX Length = 403 Score = 152 bits (383), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 79/154 (51%), Positives = 106/154 (68%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G G+DVHAFG +++ GV++P+ +G LAHSDGDV LHAL DA+LGA A GDIG Sbjct: 234 IRTGTGYDVHAFGDGDHVMLCGVKVPHNRGFLAHSDGDVGLHALVDAILGALADGDIGSH 293 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA S + L+ A R+ A+G + N++VT+I + PK+ P MR IAE Sbjct: 294 FPPSDPQWKGAASDKFLKYAVDRVAARGGRIANLEVTMICERPKIGPLRDTMRARIAEIT 353 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 G + + VKATT+E+LGFTGR EGIA A A + Sbjct: 354 GVAISRIAVKATTSERLGFTGREEGIATTASATV 387 >UniRef50_C0R0Y4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Bacteria RepID=ISPF_BRAHW Length = 158 Score = 152 bits (383), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 75/159 (47%), Positives = 102/159 (64%), Gaps = 1/159 (0%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIG+G+D HAF +I+ G+ IPYE GL HSD D +HAL D++LGA ALGDIG Sbjct: 1 MRIGYGYDSHAFAENRKLILSGIEIPYELGLKGHSDADAVIHALIDSILGALALGDIGSH 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPD D +KG S LL + ++ K Y + N D+TII + PK+ +I MR +++ L Sbjct: 61 FPDNDSKYKGISSIVLLEKTVSIMEEKNYEISNTDITIILEKPKLRNYIDTMRENLSKIL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 +++V++KA T EK+ GRGEGIA V+LL K TK Sbjct: 121 KTDIENVSIKAKTNEKMDSIGRGEGIAVHCVSLL-KKTK 158 >UniRef50_UPI0001913A58 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Salmonella enterica subsp. enterica serovar Typhi RepID=UPI0001913A58 Length = 128 Score = 151 bits (381), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 85/87 (97%), Positives = 86/87 (98%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL Sbjct: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAK 87 FPDTDPAFKGADSRELLREAWRRIQ + Sbjct: 61 FPDTDPAFKGADSRELLREAWRRIQPR 87 >UniRef50_Q2IW23 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=10 Tax=Alphaproteobacteria RepID=ISPDF_RHOP2 Length = 401 Score = 150 bits (379), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 80/154 (51%), Positives = 105/154 (68%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G G+DVHAFG + + G+++P+ +G LAHSDGDV LHAL DA+LGA A GDIG Sbjct: 234 IRTGTGYDVHAFGDGDHVWLCGLKVPHNRGFLAHSDGDVGLHALVDAILGALADGDIGSH 293 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP TDP +KGA S + L+ A R+ A+G + N++VT+I + PK+ P MR IAE Sbjct: 294 FPPTDPQWKGAASDKFLKYAVDRVAARGGRIANLEVTMICERPKIGPLRDPMRQRIAEIT 353 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 G + V VKATT+E+LGFTGR EGIA A A + Sbjct: 354 GVPVSRVAVKATTSERLGFTGREEGIAATASATI 387 >UniRef50_C9LKY7 IspD/IspF enzyme n=1 Tax=Dialister invisus DSM 15470 RepID=C9LKY7_9FIRM Length = 392 Score = 149 bits (375), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 72/156 (46%), Positives = 101/156 (64%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R+G G+D+H F P+ +GG++I GL HSD DV +HA+ DALLGAA L DIG Sbjct: 232 IRVGEGYDIHRFEVSRPLFLGGIKIADSGGLSGHSDADVLIHAIMDALLGAAGLPDIGHF 291 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPD+D F GA S ELL++ R I + Y +GN+D T+IA+ PK+ +I M+ ++ L Sbjct: 292 FPDSDVRFDGACSLELLKQVSRHITKQNYLIGNIDSTVIAEKPKISEYIEAMKAIMSAAL 351 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 + +N+KATT EKLG GRG+GIA A +L + Sbjct: 352 NISKNQINIKATTNEKLGDIGRGKGIAALASVILFR 387 >UniRef50_Q7VFU3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Campylobacterales RepID=ISPDF_HELHP Length = 389 Score = 149 bits (375), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 77/148 (52%), Positives = 95/148 (64%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 IG+G DVH F + +GGV I G AHSDGDV LHAL+DA+LGA GDIG+ FP Sbjct: 225 IGNGIDVHQFEKNKQMWLGGVEIESPFGFKAHSDGDVVLHALSDAILGAIGGGDIGEWFP 284 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 DTD +K ADS+ +L E + Q+ GY L N D++IIAQ PK+ P+ MR IA L Sbjct: 285 DTDETYKNADSKMMLSEIYTFAQSVGYELYNADISIIAQTPKIAPYKSAMRECIARILRV 344 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEA 150 +N+KATTTE LGF GR EG+ EA Sbjct: 345 PNAHINIKATTTEGLGFVGREEGVCVEA 372 >UniRef50_Q2RFM1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=4 Tax=Bacteria RepID=ISPF_MOOTA Length = 163 Score = 149 bits (375), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 91/155 (58%), Positives = 110/155 (70%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIG+G+DVH +++GGV IPY++GL HSD DV LHAL DALLGAAALGDIG Sbjct: 1 MRIGYGYDVHGLVPGRKLVLGGVTIPYDRGLAGHSDADVLLHALADALLGAAALGDIGHY 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP DP +K ADS LLRE +R +Q GY L N D TI AQ P++ P+I MR IA L Sbjct: 61 FPPGDPRYKDADSMLLLREVYRHVQTAGYRLANADATITAQEPRLAPYIDAMRERIAAAL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 G + ++VKATTTE LGFTGRGEGI+ +AV LL+ Sbjct: 121 GVTKEQISVKATTTEGLGFTGRGEGISAQAVVLLL 155 >UniRef50_B1GYT3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=ISPF_UNCTG Length = 160 Score = 148 bits (374), Expect = 5e-35, Method: Compositional matrix adjust. Identities = 72/159 (45%), Positives = 100/159 (62%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 M IG G+D H +I+GGV+I +GL HSD DV +HAL DALLGAA L DIG Sbjct: 1 MYIGFGYDAHRLKKGRELILGGVKILTSEGLDGHSDADVLIHALMDALLGAAGLNDIGHF 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPD DP +K S LL ++ ++ + +++ NVD+T+I +APK+ P I M+ I+ + Sbjct: 61 FPDMDPKYKNVSSISLLESVYKELKKQNFSVNNVDITVIVEAPKICPFIADMKENISRVI 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 + + +KATT EK+GF GRGEGIA AVA + + K Sbjct: 121 ELKRERIGIKATTNEKMGFVGRGEGIAAVAVASISQEKK 159 >UniRef50_Q9CAK8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, chloroplastic n=38 Tax=Viridiplantae RepID=ISPF_ARATH Length = 231 Score = 148 bits (373), Expect = 7e-35, Method: Compositional matrix adjust. Identities = 75/156 (48%), Positives = 101/156 (64%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 RIGHGFD+H P+IIGG+ IP+++G AHSDGDV LH + DA+LGA L DIG++ Sbjct: 75 FRIGHGFDLHRLEPGYPLIIGGIVIPHDRGCEAHSDGDVLLHCVVDAILGALGLPDIGQI 134 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPD+DP +KGA S ++EA R + GY +GN+D T+I Q PK+ PH +R +++ L Sbjct: 135 FPDSDPKWKGAASSVFIKEAVRLMDEAGYEIGNLDATLILQRPKISPHKETIRSNLSKLL 194 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 G VN+KA T EK+ G IA V LL+K Sbjct: 195 GADPSVVNLKAKTHEKVDSLGENRSIAAHTVILLMK 230 >UniRef50_Q1QBM3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=16 Tax=Bacteria RepID=ISPF_PSYCK Length = 168 Score = 147 bits (372), Expect = 8e-35, Method: Compositional matrix adjust. Identities = 89/159 (55%), Positives = 109/159 (68%), Gaps = 4/159 (2%) Query: 1 MRIGHGFDVHAFGGEGP----IIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGD 56 ++IG G DVHAF G +++ GV I + LLAHSDGDV LHAL DALLGA ALGD Sbjct: 4 IKIGQGIDVHAFHNNGQQQQYVVLAGVPIDHTHSLLAHSDGDVVLHALADALLGALALGD 63 Query: 57 IGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFI 116 IG+ FPDTD A G DSR LLR + ++ A GY LGN D+T++ + PK+ PH MR I Sbjct: 64 IGQHFPDTDAANAGLDSRVLLRYVYGKVLAAGYILGNADITVMCERPKLAPHNLAMRANI 123 Query: 117 AEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 A DL + +++VKATTTEKLGFTGR EGI AV LL+ Sbjct: 124 ASDLQTDVSNISVKATTTEKLGFTGRQEGIMANAVVLLV 162 >UniRef50_C3XLN9 Bifunctional enzyme ispD/ispF n=1 Tax=Helicobacter winghamensis ATCC BAA-430 RepID=C3XLN9_9HELI Length = 400 Score = 147 bits (370), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 80/152 (52%), Positives = 96/152 (63%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 +G G D+H I +GG+ I L+AHSDGDV LHAL DA+LGA GDIG+ FP Sbjct: 239 VGIGNDIHTLASGNGITLGGIFIDCPYQLIAHSDGDVCLHALCDAILGAIGAGDIGEWFP 298 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 D DP +KGADS+ELL+ GY+L VD+TI AQ PK+ P M IA+ LG Sbjct: 299 DNDPKYKGADSKELLQRIVDFTYNVGYSLKQVDITIFAQKPKISPFKKIMESQIAKLLGI 358 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 VNVKATTTEKLGF GRGEGI +A +L Sbjct: 359 PNFKVNVKATTTEKLGFVGRGEGIFAQANIVL 390 >UniRef50_B6DX86 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Guillardia theta RepID=B6DX86_GUITH Length = 225 Score = 145 bits (367), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 78/165 (47%), Positives = 106/165 (64%), Gaps = 7/165 (4%) Query: 1 MRIGHGFDVHAFG-----GEGPIIIGGVRIP-YEKGLLAHSDGDVALHALTDALLGAAAL 54 RIGHGFD+H G+G +IGGV++ +E G AHSDGDV H++TDA+LGA +L Sbjct: 62 FRIGHGFDIHRLAPLEVAGQG-CVIGGVKVENFELGTEAHSDGDVLYHSVTDAILGALSL 120 Query: 55 GDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRV 114 DIG+L PDTDP +KG DS + L EAW+ + +GY + N+DVT+I + PK+ P +M Sbjct: 121 PDIGQLSPDTDPKWKGCDSEKFLAEAWKLMDERGYQVSNLDVTLILERPKVSPIKSRMED 180 Query: 115 FIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 ++ L +D VNVKA T EK+ G G +AC AV L+ K K Sbjct: 181 NLSRVLKAELDVVNVKARTHEKVDSIGEGRAMACHAVILMEKKAK 225 >UniRef50_A8LKV5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=16 Tax=Alphaproteobacteria RepID=ISPDF_DINSH Length = 400 Score = 145 bits (367), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 71/156 (45%), Positives = 105/156 (67%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G+G+DVH FG +I+ GV +P+++ L+ HSD DV +HA+TDA+ GA GDIG+ Sbjct: 244 IRTGNGYDVHRFGTGDAVILCGVEVPHDRALMGHSDADVGMHAVTDAIYGALGDGDIGQH 303 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA S LR A +GYT+ ++D T++ + PK+ P+ M+ ++E + Sbjct: 304 FPPSDPQWKGAASEIFLRHAVALAAERGYTITHMDCTLVCERPKIGPYHAVMKAKMSELM 363 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 G D V+VKATT+E+LGFTGR EGIA A L++ Sbjct: 364 GLQPDQVSVKATTSERLGFTGREEGIAALATVTLVR 399 >UniRef50_Q7MQW9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Proteobacteria RepID=ISPDF_WOLSU Length = 379 Score = 145 bits (366), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 81/152 (53%), Positives = 101/152 (66%), Gaps = 2/152 (1%) Query: 4 GHGFDVHAF-GGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 G GFDVHAF GEG + + GV IP AHSDGDVA+HAL DALLGAA GDIG+ FP Sbjct: 216 GSGFDVHAFMEGEG-LRLAGVNIPAPVTFKAHSDGDVAIHALIDALLGAAGAGDIGEWFP 274 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 D+D A+KG DS LL+E + I+ G+ L N D+TI+AQAPK+ P+ M + E + Sbjct: 275 DSDLAYKGVDSTLLLQEVIKFIRGIGFELINADLTIMAQAPKLSPYKEAMERRLGEVMEV 334 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 ++VKATTTE LGF GR EG+A A +L Sbjct: 335 SRQRISVKATTTESLGFVGRKEGVAVSAQVVL 366 >UniRef50_C1FJN6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Micromonas sp. RCC299 RepID=C1FJN6_9CHLO Length = 256 Score = 145 bits (365), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 74/162 (45%), Positives = 103/162 (63%), Gaps = 5/162 (3%) Query: 1 MRIGHGFDVHAFG--GEGP---IIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALG 55 MR+GHGFD+H E P + +GG+++ +++G +AHSDGDV LH + DA+ GA L Sbjct: 60 MRVGHGFDLHRMELLSEMPDLELWLGGIKLEHDRGCVAHSDGDVLLHCVFDAITGALGLP 119 Query: 56 DIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVF 115 DIG+ FPD DP +KG S ++EA R ++ GY +GN+D TIIAQ PK+ PH ++ Sbjct: 120 DIGQCFPDNDPKWKGCTSDVFIKEAVRLMRDSGYEMGNIDCTIIAQRPKISPHKKAIKEN 179 Query: 116 IAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 +A+ L C VNVKA T EK+ G IAC V +L+KA Sbjct: 180 LAKLLECDEGLVNVKAKTHEKVDSLGENRSIACHTVCMLVKA 221 >UniRef50_C7GYL8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7GYL8_9FIRM Length = 171 Score = 145 bits (365), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 76/156 (48%), Positives = 100/156 (64%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G G+DVH II+GG++IP E + AHSDGDV H++ DA+LGAA LGDIG+ Sbjct: 14 IRTGIGYDVHKLVPGSEIILGGIKIPCEFSIEAHSDGDVLCHSIMDAMLGAAGLGDIGEH 73 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD KGA S ELL++ +++ G + N+D II + PK+ +M+ IA + Sbjct: 74 FPDTDAKLKGASSMELLKDVNDKLKKAGMKVANIDAIIILEKPKISEMKVKMKENIANVI 133 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 M VN+KATTTEKLG GR EGIA +AV L K Sbjct: 134 EIDMGRVNIKATTTEKLGSIGRSEGIASQAVVTLEK 169 >UniRef50_A5VQP4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=88 Tax=Proteobacteria RepID=ISPDF_BRUO2 Length = 409 Score = 145 bits (365), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 77/155 (49%), Positives = 101/155 (65%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G+G+DVH+F + + GV+IP+E L HSD DVALHALTDALL GDIG Sbjct: 248 IRTGNGYDVHSFEPGDHVTLCGVKIPHEAKLNGHSDADVALHALTDALLATRGAGDIGTH 307 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA SR + A + ++ G + NVDVT+I++APK+ PH M + + L Sbjct: 308 FPPSDPQWKGAASRIFIEHAAKIVREAGGRIANVDVTLISEAPKIGPHRAAMTQALCDML 367 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 G D V++KATT EKLGF GR EGIA A A +I Sbjct: 368 GIAADRVSIKATTNEKLGFVGRREGIAAIATATVI 402 >UniRef50_A5V2U9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=8 Tax=Bacteria RepID=ISPDF_SPHWW Length = 382 Score = 143 bits (361), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 82/153 (53%), Positives = 99/153 (64%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 R GFDVH F + +GGVRI +++ L HSD DVALHALTDALLG A GDIG F Sbjct: 225 RTAMGFDVHGFTAGDGVQLGGVRIAHDRALAGHSDADVALHALTDALLGTIAAGDIGSHF 284 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 P +D +KGADS L A + A G + VD+TII +APK+ PH +R IA LG Sbjct: 285 PPSDQRWKGADSAMFLAHARDLVAAAGGIVDFVDLTIICEAPKVGPHRAAIRDRIAALLG 344 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 V+VKATTTE+LGFTGR EGIA +AVA + Sbjct: 345 LTAGQVSVKATTTERLGFTGRREGIAAQAVATV 377 >UniRef50_Q2GER2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Neorickettsia RepID=ISPF_NEOSM Length = 168 Score = 142 bits (359), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 75/163 (46%), Positives = 100/163 (61%), Gaps = 8/163 (4%) Query: 2 RIGHGFDVHAF-----GGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAAL-- 54 R+G G+DVH G I++ GV +P E ++AHSDGDVALHAL DALLGAA + Sbjct: 3 RVGFGYDVHKIDKPVKTGNTCIVLCGVSVPCEYKVIAHSDGDVALHALVDALLGAACIEG 62 Query: 55 -GDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMR 113 DIG LFPDTD ++G S + IQ GY + N D+TI+ + P++ + +M+ Sbjct: 63 ANDIGMLFPDTDEKWRGKSSSYFVEHVVTLIQRAGYVVNNADLTIVCETPRIQQYKSEMQ 122 Query: 114 VFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 +A+ L + +NVKATTTEKLGF GR EGIA A+ L K Sbjct: 123 QQVADLLCVRKEQINVKATTTEKLGFEGRKEGIAAYAIVSLTK 165 >UniRef50_Q2K8V5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=7 Tax=cellular organisms RepID=ISPDF_RHIEC Length = 406 Score = 142 bits (358), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 74/155 (47%), Positives = 102/155 (65%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G+G+DVH + + GV IP+++ L HSD DVALHALTDALL GDIG Sbjct: 246 VRTGNGYDVHQLEPGDGVTLCGVFIPHDQRLKGHSDADVALHALTDALLATCGAGDIGDH 305 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA S+ + A R ++ +G T+ N DV++IA+APK+ PH MR ++E L Sbjct: 306 FPPSDPQWKGAASKIFIEHAARIVRERGGTIMNADVSLIAEAPKVGPHREAMRARLSEYL 365 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 G ++ +VKATT EK+GF GR EGIA A A ++ Sbjct: 366 GIDIERCSVKATTNEKIGFVGRREGIAAIATATVV 400 >UniRef50_C0QQE6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Hydrogenothermaceae RepID=C0QQE6_PERMH Length = 168 Score = 142 bits (357), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 74/155 (47%), Positives = 98/155 (63%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 RIG GFD+H +IIGGV+IP+EKG AHSDGD+ HALTDALLGA GDIG+LF Sbjct: 4 RIGTGFDIHRLEEGRKLIIGGVQIPFEKGFKAHSDGDIFFHALTDALLGAIGYGDIGQLF 63 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 PD+D ++GADS L+EA R ++ KGY + N+D I+ + PK+LP ++ A L Sbjct: 64 PDSDKKWEGADSSIFLKEASRIVKEKGYEIVNIDCYILLERPKLLPFREKIIENTANILQ 123 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 + + +K + EKLG GR E + V LL K Sbjct: 124 IDKNRIFIKGKSYEKLGEIGRSEAGSAHVVVLLRK 158 >UniRef50_A6U8F8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=12 Tax=Proteobacteria RepID=ISPDF_SINMW Length = 404 Score = 141 bits (356), Expect = 6e-33, Method: Compositional matrix adjust. Identities = 75/158 (47%), Positives = 102/158 (64%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G+G+DVH + + GV IP+++ L HSD DVALHALTDALL GDIG Sbjct: 243 VRTGNGYDVHQLVEGDGVTLCGVFIPHDRKLSGHSDADVALHALTDALLATCGAGDIGDH 302 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA S L A R ++ +G T+ + D+++IA+APK+ PH QMR ++ L Sbjct: 303 FPPSDPRWKGAPSHIFLEHAARIVRERGGTITHADISLIAEAPKVGPHRQQMRESLSAML 362 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 +D +VKATT EKLGF GR EGIA A A ++ A+ Sbjct: 363 AIAIDRCSVKATTNEKLGFVGRNEGIAAIATATVVYAS 400 >UniRef50_C5EY67 Bifunctional enzyme ispD/ispF n=2 Tax=Helicobacter RepID=C5EY67_9HELI Length = 386 Score = 140 bits (352), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 75/152 (49%), Positives = 96/152 (63%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 IG+G D+HA II+GG+ IP + L+AHSDGDV LHA++DA+LG GDIG+ FP Sbjct: 224 IGNGSDIHALKSGNGIILGGISIPCDFELIAHSDGDVCLHAISDAILGGIGAGDIGEWFP 283 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 D + A+K ADS LL++ GY + D+TI AQ PK+ P+ M I+E L Sbjct: 284 DNNNAYKNADSALLLKKIVDFSINVGYQITQADITIFAQKPKLSPYKNAMEKRISEILEI 343 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 + VNVKATTTE LGF GRGEGI +A L Sbjct: 344 PLFSVNVKATTTEHLGFIGRGEGIMVQATLAL 375 >UniRef50_Q5GSM7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=13 Tax=Rickettsiales RepID=ISPDF_WOLTR Length = 405 Score = 138 bits (348), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 73/160 (45%), Positives = 100/160 (62%), Gaps = 5/160 (3%) Query: 2 RIGHGFDVHAF-----GGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGD 56 R+G G+D+H F + I I GV I Y+ + AHSDGDVA+HA+ DA+LGA GD Sbjct: 240 RVGTGYDIHRFIKAQGKAKSFIKICGVEIEYDMKIEAHSDGDVAIHAVVDAILGALGCGD 299 Query: 57 IGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFI 116 IG FP + P +K +S L A ++ + KGY++ N+D+TI+ + PK+ P+ M+ FI Sbjct: 300 IGAHFPPSFPEWKDRNSSHFLDFAAKKAKEKGYSVSNLDITIVCEEPKISPYKVAMKKFI 359 Query: 117 AEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 ++ L + VNVKATTTEKLG GR EGI A LL K Sbjct: 360 SKTLEIDSEFVNVKATTTEKLGSIGRNEGILAHASVLLYK 399 >UniRef50_B1I0S9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=9 Tax=Bacteria RepID=ISPDF_DESAP Length = 394 Score = 138 bits (347), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 68/141 (48%), Positives = 94/141 (66%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 +G G+DVH + +I+GGV +P+++GLL HSD DV +HA+ DALLGAA GDIG+ FP Sbjct: 232 VGFGYDVHRLVDDRKLILGGVEVPHDRGLLGHSDADVLVHAVMDALLGAAGAGDIGRWFP 291 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 D DP ++G S +LL ++ +G N+D ++A+AP++ P I +MR +A LG Sbjct: 292 DDDPTYRGISSMDLLVRVAAFLRERGLETSNLDAVVVAEAPRLSPFISRMRDNLASVLGV 351 Query: 123 HMDDVNVKATTTEKLGFTGRG 143 VNVKATTTE LGFTG G Sbjct: 352 SPAAVNVKATTTEGLGFTGSG 372 >UniRef50_Q4FM31 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Candidatus Pelagibacter RepID=ISPDF_PELUB Length = 371 Score = 136 bits (343), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 68/156 (43%), Positives = 94/156 (60%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 ++ G GFDVH + +GGV+IP G L HSDGD LHA+TDA+LGA ++GDIG+ Sbjct: 214 IKFGIGFDVHRLVPNKKLYLGGVKIPSPIGTLGHSDGDPVLHAVTDAILGACSMGDIGEK 273 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 F D + FK S LL E ++ KGY + N+D+ II Q PK+ + Q+ IA+ Sbjct: 274 FSDKNKKFKNIRSTILLSEIIKQTLKKGYLINNLDINIITQKPKIQKYKKQILNCIAKIC 333 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 +N+K TTEKLG G+ + IACE +A +IK Sbjct: 334 NISPTQINIKGKTTEKLGVIGKEKAIACEVIASVIK 369 >UniRef50_B9JW91 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=6 Tax=Alphaproteobacteria RepID=ISPDF_AGRVS Length = 407 Score = 136 bits (342), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 72/155 (46%), Positives = 100/155 (64%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G+G+DVH + + G+ I +++ L HSD DVALHALTDALL GDIG Sbjct: 247 VRTGNGYDVHQLVPGDGVTLCGIFIAHDQALSGHSDADVALHALTDALLATCGAGDIGDH 306 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP ++GA SR L A ++ G T+ N D+++IA+APK+ PH MR ++E L Sbjct: 307 FPPSDPQWRGAASRIFLEHAANIVRDAGGTIMNADISLIAEAPKIGPHRQIMREKLSEIL 366 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 G ++ +VKATT EK+GF GRGEGIA A A ++ Sbjct: 367 GIALERCSVKATTNEKIGFVGRGEGIAAIATATVV 401 >UniRef50_B8E112 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Dictyoglomus turgidum DSM 6724 RepID=B8E112_DICTD Length = 164 Score = 135 bits (341), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 71/154 (46%), Positives = 102/154 (66%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R+G G+DVH F + +GG++IP++KGL HSDGDV +HA+ DALLGA+AL DIG Sbjct: 9 IRVGLGYDVHPFEEGRELFLGGIKIPFDKGLKGHSDGDVLIHAIADALLGASALPDIGYF 68 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP D + +G S +L + ++ KG + N+D TIIA+ PK++P ++ ++ L Sbjct: 69 FPVDDKSIEGIPSTIILEKVRDLLKEKGVNIINIDCTIIAEEPKIMPFRDKIIKNLSSIL 128 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 D ++VKATT EKLGF G+ EGIA AVAL+ Sbjct: 129 RIPEDCLSVKATTNEKLGFIGKKEGIAVFAVALV 162 >UniRef50_D1CCF0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CCF0_THET1 Length = 159 Score = 135 bits (340), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 75/151 (49%), Positives = 97/151 (64%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MR G GFD H F ++IGGV IP+ GL HSD DV HA+ DALLGAA++GDIG L Sbjct: 1 MRSGIGFDAHRFVVGRKLVIGGVAIPHHMGLEGHSDADVLTHAIIDALLGAASMGDIGTL 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 F DP G DS +LL + ++ G+ + +VD TIIAQAP+M P+I MR I++ + Sbjct: 61 FSSDDPDLAGVDSTKLLAKVCEYVRGAGWDIDHVDSTIIAQAPRMSPYIGAMRDKISKVM 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAV 151 + V++KATTT+ LG GR EGIA AV Sbjct: 121 EIPLTSVSIKATTTDGLGPWGREEGIAALAV 151 >UniRef50_Q310X3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Desulfovibrionales RepID=ISPDF_DESDG Length = 399 Score = 135 bits (339), Expect = 6e-31, Method: Compositional matrix adjust. Identities = 77/159 (48%), Positives = 99/159 (62%), Gaps = 2/159 (1%) Query: 3 IGHGFDVHAFGGEG-PIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 +G G+DVH FG +G P+ +GGV I G++AHSDGDV LHALTDA+LG LGDIG LF Sbjct: 241 VGWGYDVHRFGSDGRPMKLGGVPIAGGPGVIAHSDGDVLLHALTDAVLGCMGLGDIGMLF 300 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 PDTD A+ ADS +L E + + G + +VD+TII Q P++ P Q+ I Sbjct: 301 PDTDAAYDNADSAVMLNEVLEKARNAGLLITHVDLTIITQIPRITPWRDQIHKNICRITR 360 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGI-ACEAVALLIKATK 159 VN+KATT EKLGFTG +GI A AV L + + Sbjct: 361 LDASSVNLKATTEEKLGFTGEKKGIKAVAAVTALRRVSS 399 >UniRef50_Q9ZM19 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=14 Tax=Helicobacter RepID=ISPDF_HELPJ Length = 409 Score = 135 bits (339), Expect = 6e-31, Method: Compositional matrix adjust. Identities = 67/148 (45%), Positives = 96/148 (64%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 IG GFD HAF + P+++GGV + E GL AHSDGD LHA+ DA+LGA GDIG+ FP Sbjct: 252 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 311 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 D DP +K A S+ELL+ Q+ G+ L + TI ++ PK+ P+ P + +++ LG Sbjct: 312 DNDPKYKNASSKELLKIVLDFSQSIGFELLEMGATIFSEIPKITPYKPAILENLSQLLGL 371 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEA 150 +++KATT EK+GF G+ EG+ +A Sbjct: 372 EKSQISLKATTMEKMGFIGKQEGLLVQA 399 >UniRef50_A7HDA2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=5 Tax=Bacteria RepID=ISPDF_ANADF Length = 386 Score = 132 bits (332), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 79/154 (51%), Positives = 102/154 (66%), Gaps = 1/154 (0%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 +G G+D H F +++GGV + GLL HSD DV HA+ DA+LG A LGD+G+ FP Sbjct: 232 MGVGYDTHRFAEGRRLVLGGVEFEGD-GLLGHSDADVCAHAIGDAILGGAGLGDLGRHFP 290 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 DTDP +KG S LLRE ++ A G+ +GN DVT+ A+ PK+ P +MR +AE LG Sbjct: 291 DTDPRWKGVSSLALLREIAAKVAAAGFRVGNCDVTLAARRPKIAPRAEEMRARLAEALGV 350 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 VNVKATT E +GF GRGEGIA AVALL++ Sbjct: 351 TPGQVNVKATTGEGMGFVGRGEGIAAHAVALLVR 384 >UniRef50_Q0APQ6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=10 Tax=Proteobacteria RepID=ISPDF_MARMM Length = 383 Score = 132 bits (332), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 73/148 (49%), Positives = 94/148 (63%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G G+DVH + + GV I GL+ HSD D LHALTDA+LGAA GDIG+ FP Sbjct: 229 GQGYDVHRLEPADVMWLCGVEIRAGLGLIGHSDADAGLHALTDAVLGAAGAGDIGQHFPP 288 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCH 123 +DP +KGA S L A + ++ G L + D+T+IA+ PK+ PH MR +AE G Sbjct: 289 SDPQWKGAASDAFLLHAIKLLKQVGGELVHADITLIAERPKIGPHRDAMRARVAELTGLP 348 Query: 124 MDDVNVKATTTEKLGFTGRGEGIACEAV 151 VN+ ATTTEKLGFTGRGEG+A +A+ Sbjct: 349 EKRVNIAATTTEKLGFTGRGEGLAAQAI 376 >UniRef50_C4XSW4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=7 Tax=Desulfovibrionales RepID=ISPDF_DESMR Length = 400 Score = 132 bits (331), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 78/159 (49%), Positives = 102/159 (64%), Gaps = 10/159 (6%) Query: 4 GHGFDVHAFGGEG--------PIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALG 55 G+G+DVH + P+ +GG I +LAHSDGDV LHALTDA+LG A G Sbjct: 238 GYGYDVHRYADPRNPGKQPPRPMKLGGFPILGAPEVLAHSDGDVLLHALTDAVLGCVAGG 297 Query: 56 DIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVF 115 DIG+LFPD++P F S L EA +AKG T+ +VD+TIIAQ PK+ PH +R+ Sbjct: 298 DIGRLFPDSNPDFDNMASGVFLSEALLAAKAKGLTITHVDLTIIAQIPKISPHAEAIRLN 357 Query: 116 IAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 +A LG + + VN+KATT E LGFTG +GI +AVAL+ Sbjct: 358 VAALLGLNKEQVNLKATTEEGLGFTGEKKGI--KAVALV 394 >UniRef50_C3XI64 Bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Helicobacter bilis ATCC 43879 RepID=C3XI64_9HELI Length = 485 Score = 131 bits (330), Expect = 6e-30, Method: Composition-based stats. Identities = 70/157 (44%), Positives = 98/157 (62%), Gaps = 1/157 (0%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 IG+G D+H F + + GV+I G AHSDGDVA+HA+ D++LGA GDIG+LFP Sbjct: 328 IGYGSDIHGFIDSKDMYLCGVKIESSMGFKAHSDGDVAIHAIIDSILGAMNYGDIGELFP 387 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 D+ FK DS+ LL+E + + G L N+D+TI AQ P++ P+ QM+ +A L Sbjct: 388 DSKDEFKNIDSKILLKEVYDYCLSVGLELINLDITITAQTPRISPYKAQMQEVLANILYL 447 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 V++KA+T E LGF GR EG+ ++A L KA K Sbjct: 448 PKMCVSIKASTAEGLGFVGRKEGVLVNSIAQL-KARK 483 >UniRef50_Q1IVA8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Candidatus Koribacter versatilis Ellin345 RepID=ISPF_ACIBL Length = 155 Score = 130 bits (328), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 68/141 (48%), Positives = 89/141 (63%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R+G GFD H F P+ IGG+ IP+ GL HSDGDV LHA+TDALLGA A GDIG Sbjct: 2 IRVGLGFDSHEFREGIPLRIGGLTIPHTHGLSGHSDGDVLLHAITDALLGAVAAGDIGAF 61 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA+S + EA R I+ GY +GNVD +++ APK+ PH ++ +A+ L Sbjct: 62 FPPSDPKWKGANSVVFIEEAMRHIETAGYRVGNVDCSLVLNAPKIGPHAKAIQESVAKLL 121 Query: 121 GCHMDDVNVKATTTEKLGFTG 141 V +KA T E L G Sbjct: 122 KIEPTAVGIKAKTPEGLNLDG 142 >UniRef50_D1B5E2 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B5E2_THEAS Length = 381 Score = 130 bits (327), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 75/157 (47%), Positives = 97/157 (61%), Gaps = 2/157 (1%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIP-YEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 R GHG+DVH P+I+GG+ I GL HSD D HA+ DA+LGAA DIG L Sbjct: 226 RCGHGYDVHPLVPGRPLILGGLEIEGANLGLQGHSDADAVCHAVADAILGAAGEPDIGTL 285 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +D +KGA S +LL EA+RR+ G+ + VDVTI AQ PK+ IP++R I+ L Sbjct: 286 FPASDDRYKGAYSLDLLAEAYRRVVQGGFQIQWVDVTINAQVPKLSSWIPRIRSSISRAL 345 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 G + VNVK + E +G GRGE I C AVA L ++ Sbjct: 346 G-GLKVVNVKVKSGEHVGSVGRGESIVCHAVATLRRS 381 >UniRef50_D1BMU2 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase n=6 Tax=Bacteria RepID=D1BMU2_VEIPT Length = 391 Score = 130 bits (327), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 67/151 (44%), Positives = 93/151 (61%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MR+G G+D+H P I+GGV+I + G HSD DV +HAL DALLGAA L DIG Sbjct: 233 MRVGFGYDIHQLKAGRPCILGGVQIESDLGPDGHSDADVLIHALMDALLGAAGLRDIGYY 292 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP D +KG S LL + ++ +G N+D+ +I++ PK+ PHI M++ + L Sbjct: 293 FPPEDDQYKGISSMLLLEKVNFLLKERGLQAYNIDIMVISETPKLKPHIDMMKMNLQSIL 352 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAV 151 +D +++KATT E LG GR EGIA +AV Sbjct: 353 EIPLDRISIKATTNEMLGAIGRREGIAAQAV 383 >UniRef50_A3ZYT9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A3ZYT9_9PLAN Length = 162 Score = 129 bits (325), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 68/156 (43%), Positives = 95/156 (60%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIG G D H GP+ +GGV I +++ L+ HSD DV +HA+TDALLGAA L DIG+ Sbjct: 2 IRIGLGHDTHRLAEGGPLRLGGVDILHDQHLVGHSDADVLMHAITDALLGAANLPDIGEW 61 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP++ +G DS + LR A+ ++ +G+ + N+D I AQ PK+ P+ MR +A L Sbjct: 62 FPNSAAENRGRDSADFLRFAYHKVNEEGWRIINIDTVIFAQEPKLSPYKEAMRTALANIL 121 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 V +KA T E++G GR E I E V LL K Sbjct: 122 TIEPAQVGIKAKTGEQVGLVGRREAIQAECVVLLEK 157 >UniRef50_C1F762 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F762_ACIC5 Length = 207 Score = 129 bits (323), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 69/139 (49%), Positives = 89/139 (64%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIG+G+D HAF P+ IGG+ I + +GL HSDGDV LHA+TDALLGA A GDIG Sbjct: 3 IRIGYGWDSHAFKPGVPLRIGGLAIEHPEGLAGHSDGDVLLHAITDALLGAVAAGDIGSF 62 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP DP +KGADS L A IQ GY + NVD T++ AP++ P +MR +A L Sbjct: 63 FPPGDPRWKGADSAIFLNIALEEIQNAGYRIANVDTTLVLAAPRIGPIAGEMRERVASLL 122 Query: 121 GCHMDDVNVKATTTEKLGF 139 + D+++KA T E LG Sbjct: 123 DIPLGDISIKAKTPEGLGL 141 >UniRef50_Q4MZY9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Theileria RepID=Q4MZY9_THEPA Length = 210 Score = 128 bits (322), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 74/158 (46%), Positives = 99/158 (62%), Gaps = 6/158 (3%) Query: 2 RIGHGFDVHAF--GGEG--PIIIGGVRIPYEK-GLLAHSDGDVALHALTDALLGAAALGD 56 R+G G+D+H GEG +I+GGV +P + +LAHSDGDV LH+++DA+LGA GD Sbjct: 51 RVGFGYDIHRVVNAGEGGKTLILGGVEVPGDSVRVLAHSDGDVVLHSISDAVLGALGKGD 110 Query: 57 IGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFI 116 IG FPDT+P F+ +S ++LR + GY+L NVD II + PK+ P Q++ + Sbjct: 111 IGDYFPDTNPQFEDYNSVKILRRVLEIAEEMGYSLVNVDACIILEYPKLGPVKSQIKENL 170 Query: 117 AEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 LG H VNVKA T EKL G+G IAC AV LL Sbjct: 171 QSLLG-HGTVVNVKAKTNEKLDSIGKGSAIACHAVVLL 207 >UniRef50_C6BS25 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase n=2 Tax=Desulfovibrio RepID=C6BS25_DESAD Length = 396 Score = 127 bits (319), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 70/154 (45%), Positives = 95/154 (61%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 +G G+DVH FG P+++GGV IP ++AHSDGDV LHAL DA+LG GDIG FP Sbjct: 241 VGWGYDVHKFGEGRPMVLGGVPIPGGPEVIAHSDGDVLLHALADAILGLFGGGDIGHHFP 300 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 DT A + S +++E + + G + +VD+T+I+Q PK+ PH +R +A +G Sbjct: 301 DTSDACENMSSGIIVKEVMAKAEEAGVEIVHVDLTVISQIPKLSPHRELIRKNVASVMGL 360 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 VNVKATT EKLGFTG +GI A +K Sbjct: 361 DKAQVNVKATTEEKLGFTGEKKGIKAVAAVTGLK 394 >UniRef50_B1Q2Q5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Perkinsus marinus RepID=B1Q2Q5_9ALVE Length = 237 Score = 127 bits (318), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 66/162 (40%), Positives = 101/162 (62%), Gaps = 6/162 (3%) Query: 1 MRIGHGFDVHAFGG----EGPIIIGGVRIP--YEKGLLAHSDGDVALHALTDALLGAAAL 54 +RIGH +D+H FG GP I+ GV +P + GL+AHSDGDV H++TDA+LG+ L Sbjct: 74 LRIGHAWDIHRFGRRSAENGPFILAGVEVPDCSDIGLVAHSDGDVIFHSVTDAILGSIGL 133 Query: 55 GDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRV 114 DIG+ +PDTDP ++G S + L + +R A G+ + ++DVT++ + PK+ +P + Sbjct: 134 RDIGQYYPDTDPEWEGQSSDKFLHDTLKRASALGFRVISIDVTLVLERPKVGKVMPAVVE 193 Query: 115 FIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 + + + + VNVKA T+EKL G G+ + AV LL K Sbjct: 194 NLRKAINDNRASVNVKARTSEKLNAAGEGKSVEAHAVVLLYK 235 >UniRef50_Q73KC6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Bacteria RepID=ISPF_TREDE Length = 161 Score = 127 bits (318), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 70/154 (45%), Positives = 97/154 (62%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MR G G+D+H +++GGV IP++KG AHSDGDV LHA+TDALLGA +GDIG+ Sbjct: 1 MRTGLGYDLHRLVRGKKLMMGGVHIPFKKGEKAHSDGDVLLHAITDALLGACGMGDIGEF 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +D +K A+S ELL W RI G+ + N+D II + PK+LP ++R IA L Sbjct: 61 FPPSDKKWKDANSSELLSTVWERISEAGWKIQNIDCVIIIEEPKILPFREEIRKSIAGIL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 + + +KA T E +G GRG+ +A A L+ Sbjct: 121 KIEKEQIFIKAKTGEGIGIIGRGKAVAALASCLI 154 >UniRef50_B2URI3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Verrucomicrobia RepID=ISPF_AKKM8 Length = 169 Score = 122 bits (305), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 68/153 (44%), Positives = 97/153 (63%), Gaps = 1/153 (0%) Query: 4 GHGFDVHAFGG-EGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 G G+D+H F P+++GGV IP +GL HSD DV HA+ DALLGAA L DIG FP Sbjct: 9 GIGYDIHRFAEVPRPLMLGGVHIPSSRGLDGHSDADVLCHAIADALLGAAGLPDIGYWFP 68 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 DP+ K S +++ +A I+ +G + NVD ++IA++P++ P++ QM+ + LG Sbjct: 69 PGDPSCKDIPSLDIVAKAVSLIRERGGRIVNVDSSLIAESPRISPYLEQMKGALGAALGI 128 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 V +KATT E+LG GR EGIA AVA ++ Sbjct: 129 SPVRVGIKATTNEQLGALGRREGIAAFAVAAIL 161 >UniRef50_B8CD73 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Thalassiosira pseudonana RepID=B8CD73_THAPS Length = 263 Score = 121 bits (304), Expect = 7e-27, Method: Compositional matrix adjust. Identities = 70/184 (38%), Positives = 99/184 (53%), Gaps = 28/184 (15%) Query: 1 MRIGHGFDVHAF-----GGEGPIIIGGVRIPYEK----------------------GLLA 33 +RIGHGFD+H G+ P++IGGV I +E G++A Sbjct: 74 LRIGHGFDIHRMVPLEEAGQ-PVVIGGVVIDHEDQKWTDKEGTYTGTPNSIYKTQLGVIA 132 Query: 34 HSDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGN 93 HSDGDV H+L DA+ GA L DIG++F DTDP +KG DS + + A+ ++ GY +GN Sbjct: 133 HSDGDVIYHSLVDAIFGALTLPDIGQVFQDTDPRWKGCDSSKFMEHAYEVMKYYGYQIGN 192 Query: 94 VDVTIIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVAL 153 VDVT+I + PK+ P+M+ I L VN+KA T E++ G ++C V Sbjct: 193 VDVTLILERPKVAGFKPRMKENIVRLLHTTDGRVNIKARTHERVDSVGELRSLSCHVVVT 252 Query: 154 LIKA 157 L K Sbjct: 253 LEKV 256 >UniRef50_D0RP30 Bifunctional enzyme IspD/ispF n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RP30_9RICK Length = 400 Score = 118 bits (295), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 56/151 (37%), Positives = 94/151 (62%), Gaps = 1/151 (0%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G G+D+H + IGG++IP + G + HSDGD LHAL D+ +GAA LGDIG LFP+ Sbjct: 248 GIGYDIHKMSPGYNLYIGGIKIPSKYGAVGHSDGDSLLHALIDSFMGAARLGDIGTLFPN 307 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCH 123 + +KG S +L+RE +++ + ++D+ II Q+P + + +++ I++ Sbjct: 308 -NKKYKGIRSTKLVREIIIKLKMINLKISSIDLNIILQSPNLKNYKEKIKKNISKLCFIK 366 Query: 124 MDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 + +N+KA TT+KLG G+ + +ACE ++ L Sbjct: 367 PNKINIKAKTTDKLGIIGKNKALACEVISTL 397 >UniRef50_B0SAT2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=6 Tax=Leptospira RepID=ISPF_LEPBA Length = 162 Score = 117 bits (294), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 62/156 (39%), Positives = 88/156 (56%), Gaps = 2/156 (1%) Query: 1 MRIGHGFDVHAFGGEG--PIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIG 58 R+G+G D H E P+++ GV I E L HSD DV LHA+ DA+LGA +LGDIG Sbjct: 2 FRVGNGIDFHKLIHEPFRPLVLAGVEIKSEFAFLGHSDADVILHAVADAILGALSLGDIG 61 Query: 59 KLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAE 118 FPDTDP +K S ++ + + K + L NVD T + PK+ P ++ +A Sbjct: 62 VHFPDTDPQYKNMKSTRIIEKCLELVAEKKFKLINVDCTYVGDHPKISPIRAELNASLAN 121 Query: 119 DLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 +D V++KATT+E +G GR EG+ A L+ Sbjct: 122 ITKLPLDCVSIKATTSEGMGALGRSEGVMVMATVLI 157 >UniRef50_C4RE02 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (Fragment) n=1 Tax=Micromonospora sp. ATCC 39149 RepID=C4RE02_9ACTO Length = 220 Score = 115 bits (287), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 67/153 (43%), Positives = 89/153 (58%), Gaps = 3/153 (1%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 R+ G DVHAF P + G+ P + GL HSD DV HA +ALL AA LGD+G F Sbjct: 65 RVAIGTDVHAFEVGRPCWLAGLLWPGQDGLAGHSDADVVAHAACNALLSAAGLGDLGSNF 124 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 +P + GA LL E RR++A G+ +GNV V ++ PK+ P + ++E +G Sbjct: 125 GVAEPEWAGAPGVALLAETARRVRAAGFEIGNVSVQVVGNRPKIGPRRAEAEAVLSEAVG 184 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 V V A TT+ LGFTGRGEG+A AVAL+ Sbjct: 185 A---PVAVSAATTDGLGFTGRGEGLAGIAVALV 214 >UniRef50_B7FYU1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B7FYU1_PHATR Length = 244 Score = 115 bits (287), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 68/180 (37%), Positives = 96/180 (53%), Gaps = 27/180 (15%) Query: 1 MRIGHGFDVH-----AFGGEGPIIIGGVRIPY---------------------EKGLLAH 34 +RIGHGFD+H A G+ P++IGGV I + E G++AH Sbjct: 62 LRIGHGFDIHRMAPLAEAGQ-PVVIGGVVIDHLPQKWTDAEGRYVEKGGVYETELGVVAH 120 Query: 35 SDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNV 94 SDGDV H++ DA+ GA L DIG++F DTDP +KG DS + + A + GY +GN+ Sbjct: 121 SDGDVIYHSIVDAIFGALTLPDIGQVFQDTDPRWKGCDSSKFMEHAHTVMADYGYKVGNI 180 Query: 95 DVTIIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 DVT+I + PK+ P M+ I L VN+KA T E++ G ++C V L Sbjct: 181 DVTLILERPKVASFKPAMKKNIVNLLQTTPGRVNIKARTHERVDSVGELRSLSCHVVMTL 240 >UniRef50_C8R0Y1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase n=1 Tax=Desulfurivibrio alkaliphilus AHT2 RepID=C8R0Y1_9DELT Length = 454 Score = 113 bits (283), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 60/134 (44%), Positives = 83/134 (61%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 RIGHG+DVH + P+I+GGV I + GLL HSD DV HAL DA+LGA GDIG+ F Sbjct: 235 RIGHGYDVHRLVTDRPLILGGVTIEHHLGLLGHSDADVLTHALCDAILGALGAGDIGRHF 294 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 PD D ++G S +LL + ++ A L + D+TIIA+ PK+ P + M+ +A Sbjct: 295 PDNDQQYRGISSLKLLAQVMTKVWAANCRLHHADLTIIAEKPKLAPQLAAMQANLAAACQ 354 Query: 122 CHMDDVNVKATTTE 135 + +N+KATTT Sbjct: 355 VNPSQINLKATTTR 368 >UniRef50_A5CTY4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=28 Tax=Actinobacteria (class) RepID=ISPDF_CLAM3 Length = 410 Score = 112 bits (279), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 64/154 (41%), Positives = 86/154 (55%), Gaps = 3/154 (1%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G G DVHA P+ + G+ P E GL HSDGD HA+ DALL AA LGDIG + Sbjct: 257 LRSGIGTDVHAVDASQPLWLAGLHWPGEAGLAGHSDGDAVSHAMCDALLSAAGLGDIGGI 316 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 F DP GA LR ++ GY + NV V ++A PK+ P + ++ + Sbjct: 317 FGTDDPELDGAHGEVFLRRTAELVRDAGYRIVNVAVQVMAVRPKLSPRRAEAERILSAAV 376 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 G V++ TTT+ LGFTGRG+G+A A AL+ Sbjct: 377 GA---PVSLAGTTTDGLGFTGRGDGVAAVATALV 407 >UniRef50_Q1MR76 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=4 Tax=Desulfovibrionaceae RepID=ISPDF_LAWIP Length = 399 Score = 111 bits (278), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 63/163 (38%), Positives = 92/163 (56%), Gaps = 7/163 (4%) Query: 3 IGHGFDVHAFGGEGPII-------IGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALG 55 +G+G+DVH + E I +GG+ IP ++AHSDGDV LHAL DALLG G Sbjct: 237 VGYGYDVHKYVTEDQINQPIRSMRLGGISIPNAPNVVAHSDGDVLLHALMDALLGCIGGG 296 Query: 56 DIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVF 115 DIG FPD+D + G +S LL ++ + ++D TI+AQ PK+ + +R Sbjct: 297 DIGLHFPDSDKRYDGINSAILLDHVLTKVLESSIKIVHMDATIVAQLPKISQYREAIRSN 356 Query: 116 IAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 ++ L + +VN+KATT E LGFTG +GI + I+ + Sbjct: 357 LSRLLDLDLANVNIKATTEEGLGFTGECKGIKAIVIVTAIRIS 399 >UniRef50_B2KDX1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase n=1 Tax=Elusimicrobium minutum Pei191 RepID=B2KDX1_ELUMP Length = 382 Score = 109 bits (273), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 56/153 (36%), Positives = 84/153 (54%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 R G GFD+H + IGG+ IP+ KG L HSDGDV LHA+ DA LGA G+IG + Sbjct: 226 RTGIGFDLHRLVEGRKLFIGGLEIPHTKGFLGHSDGDVVLHAVCDAALGAVCAGEIGVYY 285 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 P TD +G S ++ ++ ++ K + ++D II + PKM PH +R + + Sbjct: 286 PPTDAKIEGISSVDIAKKVIEILKEKNARIVHIDAVIITEEPKMKPHYQAIRESLGKVFN 345 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 +D ++ K+ + EKLG G G C+ V + Sbjct: 346 MGVDSISFKSKSHEKLGDIGAGNAAMCQCVVTV 378 >UniRef50_Q72HP8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=5 Tax=Deinococci RepID=ISPF_THET2 Length = 152 Score = 109 bits (273), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 62/137 (45%), Positives = 79/137 (57%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIG+G D H P+ + G+ IP G LAHSDGD ALHALTDALL A LGDIG L Sbjct: 1 MRIGYGEDSHRLEEGRPLYLCGLLIPSPVGALAHSDGDAALHALTDALLSAYGLGDIGLL 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTDP ++G S LREA R ++A+G L + + PK+ PH + +A L Sbjct: 61 FPDTDPRWRGERSEVFLREALRLVEARGARLLQASLVLTLDRPKLGPHRKALVDSLARLL 120 Query: 121 GCHMDDVNVKATTTEKL 137 D + + T+E L Sbjct: 121 RLPQDRIGLTFKTSEGL 137 >UniRef50_B9KAZ0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Thermotoga RepID=ISPF_THENN Length = 165 Score = 105 bits (263), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 64/156 (41%), Positives = 91/156 (58%), Gaps = 7/156 (4%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 M IG G+D H +++ GV I G L HSDGDV HA+ DALLGA LGDIG Sbjct: 6 MFIGFGYDRHPLVEGRRLVLAGVEIDAPLGSLGHSDGDVLSHAIIDALLGAGCLGDIGTW 65 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP+T +K A+S +LL+E + ++ +G+++ NVD T++A K+ P+ R I E+L Sbjct: 66 FPET-KEYKDANSLDLLKETVKILEERGFSVVNVDATVVASIVKLSPY----REKILENL 120 Query: 121 GCHMDD--VNVKATTTEKLGFTGRGEGIACEAVALL 154 ++ VNVK + LGF G GI+ AV L+ Sbjct: 121 KSALETSRVNVKFKSGNTLGFEGEERGISAYAVCLV 156 >UniRef50_B3L0R0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=4 Tax=Plasmodium RepID=B3L0R0_PLAKH Length = 272 Score = 105 bits (262), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 64/174 (36%), Positives = 89/174 (51%), Gaps = 19/174 (10%) Query: 1 MRIGHGFDVHAFGGEGP------------------IIIGGVRIPYEKGLLAHSDGDVALH 42 +RIG G+D+H P + IGGV++ +L+HSDGDV H Sbjct: 94 VRIGQGYDIHQIRVSTPEDITVDSSADANKQNFKRLTIGGVQVD-TISVLSHSDGDVIYH 152 Query: 43 ALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQA 102 AL DALLG D+G LFPD +K S LR A + K Y + N+D+ +IA+ Sbjct: 153 ALVDALLGGMNCLDLGTLFPDGSEKYKNKKSISFLRYARLLLYKKNYAIANLDIIVIAEI 212 Query: 103 PKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 PK+ P ++ I+ LG V++K T EKLG G+ + I C A ALLI+ Sbjct: 213 PKISPIREEIVRNISSALGISESQVSLKGKTHEKLGPIGQKKAIECFANALLIR 266 >UniRef50_C7M1Q8 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7M1Q8_ACIFD Length = 364 Score = 104 bits (260), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 71/156 (45%), Positives = 94/156 (60%), Gaps = 6/156 (3%) Query: 1 MRIGHGFDVHAFGGEG--PIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIG 58 +R+G G D H E P+++GGV +P GL AHSDGD HA+ DA+LGAA +G IG Sbjct: 205 VRVGLGLDQHPRSDEPGRPLVLGGVTVPG-PGLRAHSDGDALCHAVADAMLGAAGIGGIG 263 Query: 59 KLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAE 118 L+ DTDPAF+GADS ELL R ++ +G + VD TI+ + PK+ P++ +M I Sbjct: 264 DLYADTDPAFRGADSLELLAGCVRLVRGRGLRVVQVDATIVCETPKLSPYLARMARTIE- 322 Query: 119 DLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 G VKA E +G GRGEG+A AV LL Sbjct: 323 --GVVAAPALVKAKHPEGIGALGRGEGVAALAVVLL 356 >UniRef50_B1L8F8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=4 Tax=Thermotogaceae RepID=B1L8F8_THESQ Length = 160 Score = 103 bits (257), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 66/156 (42%), Positives = 88/156 (56%), Gaps = 7/156 (4%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 M IG G+D H +I+ GV I G L HSDGDV HA+ DALLGA LGDIG Sbjct: 1 MFIGFGYDRHPLVEGRRLILAGVEIDSPVGSLGHSDGDVLSHAIIDALLGAVGLGDIGTW 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP+T+ ++GA S ELL++ I+ +G+ + NVD T++ +M + R I E+L Sbjct: 61 FPETEE-YRGAISLELLKKTMGMIEERGFKVINVDSTVVLSGVRMSAY----RDRIVENL 115 Query: 121 GCHMDD--VNVKATTTEKLGFTGRGEGIACEAVALL 154 + VNVK + LGF G G GI+ AV LL Sbjct: 116 KSVLKTPHVNVKFKSGNTLGFEGEGRGISAYAVCLL 151 >UniRef50_P62368 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Plasmodium RepID=ISPF_PLAF7 Length = 240 Score = 101 bits (252), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 63/174 (36%), Positives = 86/174 (49%), Gaps = 20/174 (11%) Query: 1 MRIGHGFDVHA---------------FGGE----GPIIIGGVRIPYEKGLLAHSDGDVAL 41 +RIG G+D+H F + +GGV+I +L+HSDGD+ Sbjct: 64 IRIGQGYDIHKIKVLDEEYNTYANNDFNKNEQSFKTLTLGGVKIN-NVLVLSHSDGDIIY 122 Query: 42 HALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQ 101 H++ D++LGA DIG LFPD D K +S LR A I K Y +GNVD+ +IAQ Sbjct: 123 HSIVDSILGALGSLDIGTLFPDKDEKNKNKNSAIFLRYARLLIYKKNYDIGNVDINVIAQ 182 Query: 102 APKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 PK+ + I+ L ++VK T EKLG G + I C A LLI Sbjct: 183 VPKISNIRKNIIKNISTVLNIDESQISVKGKTHEKLGVIGEKKAIECFANILLI 236 >UniRef50_B9RCH5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Ricinus communis RepID=B9RCH5_RICCO Length = 230 Score = 100 bits (249), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 51/114 (44%), Positives = 69/114 (60%) Query: 38 DVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVT 97 DV LH + DA+LGA L DIG++FPD+DP +KGA S ++EA R + GY +GN+D T Sbjct: 71 DVLLHCVVDAILGALGLPDIGQIFPDSDPKWKGAPSSVFIKEAVRLMHEAGYDIGNLDAT 130 Query: 98 IIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAV 151 +I Q PK+ PH +R + E LG +N+KA T EK+ G IA V Sbjct: 131 LILQRPKLSPHKEAIRSNLCELLGADPSVINLKAKTHEKVDSLGENRSIAAHTV 184 >UniRef50_C1TMK1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TMK1_9BACT Length = 357 Score = 100 bits (249), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 63/158 (39%), Positives = 93/158 (58%), Gaps = 8/158 (5%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G GFDVH +++GGV +P GL HSD D+ H ++DA+LGAA L DIG++ Sbjct: 190 VRTGIGFDVHPLVPGRSLVLGGVEVPSPMGLDGHSDADIICHGISDAILGAAGLPDIGRV 249 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP D A+K ADS ELLRE +++ G+++ +DV + AQ LP I + + I ++L Sbjct: 250 FPACDDAYKDADSYELLREVVSKVERCGWSIVWLDVVLHAQ----LPRIGETVIEITKNL 305 Query: 121 GCHMDD----VNVKATTTEKLGFTGRGEGIACEAVALL 154 +D VN+K + E +G G G + C AVA + Sbjct: 306 DSVWNDGMRRVNLKVKSGEGVGSVGSGHCMMCYAVATI 343 >UniRef50_B6KAQ3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Toxoplasma gondii RepID=B6KAQ3_TOXGO Length = 338 Score = 100 bits (248), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 60/133 (45%), Positives = 83/133 (62%), Gaps = 3/133 (2%) Query: 30 GLLAHSDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAK-- 87 G++AHSDGDV LHA+ DA+ GA ALGDIG+ F D++PAF+G S L+ A ++AK Sbjct: 181 GVVAHSDGDVLLHAVCDAVFGAFALGDIGEHFSDSNPAFRGMSSSLLVARALEIVRAKHP 240 Query: 88 GYTLGNVDVTIIAQAPKM-LPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGI 146 + LG+VD T++ A K +MR +AE L V+VKA T+E +G GR E + Sbjct: 241 DWRLGSVDATVVFDAMKFGRARKQKMRENLAELLQLPAAAVSVKAKTSEGVGPVGRKEAV 300 Query: 147 ACEAVALLIKATK 159 AC V L K+T+ Sbjct: 301 ACHVVLTLFKSTR 313 >UniRef50_C1CZ33 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Deinococci RepID=C1CZ33_DEIDV Length = 167 Score = 99.4 bits (246), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 59/137 (43%), Positives = 79/137 (57%), Gaps = 1/137 (0%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPY-EKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 RIG+G D H P+I+GGV IP+ E+G +AHSDGD LHA+ DALL ALGDIG Sbjct: 13 RIGYGEDAHRLARGLPLILGGVPIPHAEQGAVAHSDGDAVLHAVADALLSGLALGDIGHY 72 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDT +K DSR +L A ++A+GY NV + + PK+ P ++ +A L Sbjct: 73 FPDTAAEYKEMDSRIILDRALMLVRARGYAPVNVALVVTLDRPKLGPLRAEIAQTVAGLL 132 Query: 121 GCHMDDVNVKATTTEKL 137 +V V T+E L Sbjct: 133 DLPATEVGVSFKTSEGL 149 >UniRef50_B1VS88 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=93 Tax=Actinomycetales RepID=ISPF_STRGG Length = 172 Score = 97.8 bits (242), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 61/155 (39%), Positives = 88/155 (56%), Gaps = 4/155 (2%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYE-KGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 +G G D+HAF + G++ E GL HSD DV HA +AL AA LGD+G+ F Sbjct: 19 VGIGTDIHAFEEGRKLWCAGLKWEGEGPGLAGHSDADVVAHAACNALFSAAGLGDLGQHF 78 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 P + GA LL EA R ++A G+ +GNV V ++ PK+ + + ++E +G Sbjct: 79 GTGRPEWSGAAGITLLTEAARIVRAGGFEIGNVAVQVVGSRPKIGKRREEAQKVLSEAVG 138 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 V++ A T++ LGFTGRGEGIA A AL+ + Sbjct: 139 A---PVSLSAATSDGLGFTGRGEGIAGLATALVYR 170 >UniRef50_B1VIQ0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=10 Tax=Actinomycetales RepID=ISPF_CORU7 Length = 162 Score = 97.4 bits (241), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 58/156 (37%), Positives = 80/156 (51%), Gaps = 3/156 (1%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 R+G D H P + G+ G HSDGDV H + DALL A+ LGD+G Sbjct: 8 RVGIASDAHQVEPGKPCWMAGLLFEDADGCEGHSDGDVVSHVIVDALLSASGLGDLGSFV 67 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 + G L+ E + + G+T+GNV +I PKM P + + E +G Sbjct: 68 GVGRKEYDGVSGERLITECRQLLAENGFTIGNVAAQMIGNRPKMGPRREEAERRLTELVG 127 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 V+V ATTT+K+GFTGRGEG+A A A++ KA Sbjct: 128 A---PVSVSATTTDKMGFTGRGEGVAALATAVVWKA 160 >UniRef50_C5CGG7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=ISPF_KOSOT Length = 156 Score = 94.7 bits (234), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 57/157 (36%), Positives = 84/157 (53%), Gaps = 6/157 (3%) Query: 2 RIGHGFDVHAF-GGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 R+G GFD H + + +GGV++ E + HSDGD +HA+ DA+LGA G+IG Sbjct: 3 RVGIGFDAHPLEANKKGLYLGGVKVSEEYSSIGHSDGDALIHAIVDAILGATNAGNIGIW 62 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP+ + +G S E L ++I A Y + N+D II +M PHI +R+ +A L Sbjct: 63 FPENEEN-RGRRSTEFLEIIRKKILAGKYEILNIDSVIIIDKVRMNPHIENIRLKLARIL 121 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 G ++NVK K G T G ++ AV +L K Sbjct: 122 GISKGNINVKP----KSGNTLYGNSVSVYAVCMLKKV 154 >UniRef50_C9M692 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase n=2 Tax=Synergistaceae RepID=C9M692_9BACT Length = 384 Score = 94.7 bits (234), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 48/131 (36%), Positives = 74/131 (56%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G G+DVH + P+++ GV +P GL HSD D+ H DA+L AA L DIG L Sbjct: 221 IRTGIGYDVHPLTPDRPLVLAGVTVPSPLGLAGHSDADIISHVAADAVLSAAGLPDIGTL 280 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 +P +D + G S +LL +A R + G+++ V + + AQ PK+ P+ P +R + + L Sbjct: 281 YPSSDEQYAGCRSMDLLADAVSRAEQAGWSVQFVSLVVTAQVPKLAPYGPAIRQALEKVL 340 Query: 121 GCHMDDVNVKA 131 G V K+ Sbjct: 341 GDGKISVTFKS 351 >UniRef50_Q7NC56 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Mycoplasma gallisepticum RepID=ISPF_MYCGA Length = 157 Score = 94.4 bits (233), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 57/156 (36%), Positives = 90/156 (57%), Gaps = 9/156 (5%) Query: 1 MRIGHGFDVHAFGGE--GPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIG 58 +RIG GFD H + + +GG+ + ++ L+A+SDGDV LHAL+DA+LG + GDIG Sbjct: 5 IRIGQGFDSHKLKTKKNSRVFLGGIPVRTDQQLIANSDGDVVLHALSDAVLGCGSFGDIG 64 Query: 59 KLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAE 118 F + D + KG DS+ +L + I+ N+D+TI AQ ++ P +++ + + Sbjct: 65 MYFDENDLSNKGLDSKTILNYCLKLIKKLKLEFVNIDLTIFAQDIRIDPIRFEIKSSLMK 124 Query: 119 DLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 GC+ VNVKA + E+ + E IAC V L+ Sbjct: 125 LTGCN--SVNVKAKSYEE----PKNE-IACSCVVLM 153 >UniRef50_Q14PQ0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Spiroplasma citri RepID=Q14PQ0_SPICI Length = 152 Score = 93.6 bits (231), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 45/136 (33%), Positives = 82/136 (60%), Gaps = 3/136 (2%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MR+G+ +D+H +GG+ IP + + A SDGD+ LH +++A++GA LGD+G+ Sbjct: 1 MRVGNSYDLHNLKMGTGFYLGGILIPCQYQVEAVSDGDILLHTISEAIIGALGLGDLGEW 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 F +T+ K +S+ +L++A + + Y + N+D TII P++ H ++ + + L Sbjct: 61 FDETN---KKINSQLILKKALTLMAEQNYQISNIDTTIIIDEPRLQKHKKAIKTNLQKLL 117 Query: 121 GCHMDDVNVKATTTEK 136 + +N+KATTTE+ Sbjct: 118 QISAEKINLKATTTEQ 133 >UniRef50_A9BHL8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Petrotoga mobilis SJ95 RepID=ISPF_PETMO Length = 162 Score = 89.4 bits (220), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 55/156 (35%), Positives = 82/156 (52%), Gaps = 4/156 (2%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKG--LLAHSDGDVALHALTDALLGAAALGDIG 58 ++IG G+DVH F +I+GGV I + KG LL HSDGDV HAL D+LLG LG IG Sbjct: 2 LKIGFGYDVHPFAENRRLILGGVVINHPKGYGLLGHSDGDVFFHALIDSLLGMCGLGSIG 61 Query: 59 KLFPDTDPAFKGADSRELLREAWRRIQAKGYT-LGNVDVTIIAQAPKMLPHIPQMRVFIA 117 + FP++ F+ S LL + I + + N+DV II+++ + Q++ + Sbjct: 62 EYFPES-KEFENISSSILLEKTIDLINKRYIVKINNIDVVIISKSVNISSITGQIKNNTS 120 Query: 118 EDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVAL 153 L + +N+K + LG G +GI L Sbjct: 121 CILNLEVSRINLKGKSGNGLGVGGNDQGIEVYCTIL 156 >UniRef50_B4U9N6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Aquificaceae RepID=ISPF_HYDS0 Length = 156 Score = 86.7 bits (213), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 59/159 (37%), Positives = 82/159 (51%), Gaps = 11/159 (6%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 RIG G D H F + +GG GL HSDGD LHA+TDA+LGA A DIG LF Sbjct: 3 RIGIGQDAHYFEKGKKLYLGGEEFDIGYGLKGHSDGDALLHAITDAILGALAKTDIGTLF 62 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 PD K +S + L +A + Y++ N+D IIA P+I +R I E L Sbjct: 63 PDKSKENKNRNSVDFLNKALEIMYDMDYSIVNLDCNIIADK----PNISSVRDKIIESLS 118 Query: 122 CHM----DDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 + D++++KA T E G+ + + + +ALL K Sbjct: 119 RLLSIPKDNISIKAKTKE--GYN-KEDSLEVVCIALLQK 154 >UniRef50_A8F4L5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Thermotoga lettingae TMO RepID=A8F4L5_THELT Length = 163 Score = 85.1 bits (209), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 52/154 (33%), Positives = 83/154 (53%), Gaps = 2/154 (1%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R+G G D H F +I+ GV I GLL HSDGD H+L D+LLGA LGDIG+ Sbjct: 4 LRVGIGTDRHPFVEGRKLILAGVEINSSVGLLGHSDGDALCHSLIDSLLGAVCLGDIGQY 63 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP+TD +K A S LL + I+ +G+ + N+D + ++ + M +++ + Sbjct: 64 FPETDE-WKDASSIFLLEKIIDMIRDQGWEVVNIDTIVTCGRIRLSDYRDDMIKNLSKIM 122 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 ++VK + LGF + +G++ + LL Sbjct: 123 NIPEQRISVKFKSANGLGFESQ-DGVSVLTICLL 155 >UniRef50_Q8EUA4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Mycoplasma penetrans RepID=Q8EUA4_MYCPE Length = 165 Score = 84.3 bits (207), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 38/101 (37%), Positives = 61/101 (60%), Gaps = 1/101 (0%) Query: 2 RIGHGFDVHAFGGEG-PIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +IG+G D+H E + G+ + ++AHSDGD+ LH+++ A+LGA +L D+G Sbjct: 17 KIGNGIDIHKIKKEKCKQRLAGLDFELDYKIIAHSDGDIILHSISSAILGALSLQDLGTY 76 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQ 101 F DTD K DS E+L ++ + Y++ NVD+TII + Sbjct: 77 FSDTDSKNKNLDSLEILSMCLNELKKQDYSISNVDITIICE 117 >UniRef50_Q83NK3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Tropheryma whipplei RepID=ISPDF_TROW8 Length = 422 Score = 80.1 bits (196), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 53/151 (35%), Positives = 76/151 (50%), Gaps = 3/151 (1%) Query: 3 IGHGFDVHAF-GGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 IG G D H F E P+ + + + L HSDGDV HA T ALL AA +GDIG +F Sbjct: 269 IGVGIDFHKFILDESPLFLACLEWKNYRRLQGHSDGDVVAHACTTALLSAANMGDIGSVF 328 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 A K A L R + G+ + N+ V +I+ P++ + I++ L Sbjct: 329 GVDLAATKDASGAYFLESTNRLLATNGFCVLNIAVQVISNTPRLADRRVEAEHAISDCLS 388 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVA 152 +++ + TT+ +GF GRGEGI AVA Sbjct: 389 GAR--ISLSSVTTDGMGFLGRGEGIGAIAVA 417 >UniRef50_B0BC71 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=18 Tax=Bacteria RepID=ISPF_CHLTB Length = 178 Score = 78.2 bits (191), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 52/161 (32%), Positives = 81/161 (50%), Gaps = 4/161 (2%) Query: 2 RIGHGFDVHAFGGE---GPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIG 58 R+G G D H F + P I+GG+ G A+SDGDV HA+ +A G +G Sbjct: 18 RVGIGQDSHRFLPDEDPKPCILGGIIFENTPGFEANSDGDVVFHAICNAFSSVTHKGILG 77 Query: 59 KLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAE 118 L + DS L+EA ++ + ++ +TI + PK+LP +P MR IAE Sbjct: 78 GLADELLKTKGITDSVVYLQEAIASLKPT-QRVSHLAITIEGKRPKLLPQLPSMRKRIAE 136 Query: 119 DLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 L +D +N+ AT+ E L G+G G+ C V +++ + Sbjct: 137 VLHIPLDSINITATSGEGLTAMGQGYGVQCFCVLTIMEYCR 177 >UniRef50_A7AVQ2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Babesia bovis RepID=A7AVQ2_BABBO Length = 199 Score = 77.8 bits (190), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 62/159 (38%), Positives = 88/159 (55%), Gaps = 7/159 (4%) Query: 2 RIGHGFDVHAFGGEG----PIIIGGVRIPYEK-GLLAHSDGDVALHALTDALLGAAALGD 56 RIG G+D+H G G P +GGV + K ++ HSDGD LHAL DALLGA GD Sbjct: 39 RIGLGYDIHRLVGTGKGGKPFKLGGVLVDDSKIFVVGHSDGDTLLHALADALLGATGCGD 98 Query: 57 IGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQ-MRVF 115 IG F + D K DSR +L A + +GY N+D+ II + ++ + ++ Sbjct: 99 IGDYFSELDSINKDMDSRIILESAIKEASLRGYRPTNIDINIILERVRLGRRLKDAIKKA 158 Query: 116 IAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 + + LG + +NVKA T E L GRGE ++C+ +A L Sbjct: 159 LYDMLGSDV-MINVKAKTNEGLDAIGRGEAVSCQVIAHL 196 >UniRef50_A6LJL2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Thermosipho melanesiensis BI429 RepID=A6LJL2_THEM4 Length = 331 Score = 73.9 bits (180), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 39/97 (40%), Positives = 56/97 (57%), Gaps = 1/97 (1%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G G+D H E +++GGV I GL HSDGDV +H++ D+LLG + DIG LFP+ Sbjct: 183 GVGWDTHKIIKERKLVLGGVEIDSTFGLKGHSDGDVVIHSIIDSLLGVSLKKDIGVLFPE 242 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIA 100 + +G S +L+E + I KGY N+D +I Sbjct: 243 SKVP-EGISSVYMLQEVVKAINRKGYFPENIDCVVIT 278 >UniRef50_B5Y8V5 Bifunctional enzyme IspD/ispF n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5Y8V5_COPPD Length = 362 Score = 73.2 bits (178), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 42/106 (39%), Positives = 62/106 (58%), Gaps = 3/106 (2%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIP-YEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 G G+D H F P+I+GGVRI + GL + +DGDV +HA+ DALL GD+G L+P Sbjct: 211 GIGWDFHRFSENAPLILGGVRIEDADVGLESWTDGDVIIHAVADALLSTLGQGDLGTLYP 270 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPH 108 ++ +KG S ++L + R++ K L V ++A P ML H Sbjct: 271 NSQ-LWKGGSSTDILADVMERMRKKHVLLEKATVLLLADKP-MLKH 314 >UniRef50_B8I5R3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=6 Tax=Bacteria RepID=B8I5R3_CLOCE Length = 168 Score = 73.2 bits (178), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 52/149 (34%), Positives = 76/149 (51%), Gaps = 5/149 (3%) Query: 1 MRIGHGFDVHAF---GGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDI 57 M++G G D H F I+GGV L +SD DV LHALT+A+ G + + Sbjct: 13 MKVGIGQDSHRFDFQNNSKKFILGGVIFDDVTPLDGNSDADVVLHALTNAISGVTCVNIL 72 Query: 58 GKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIA 117 GK+ + DS E LREA + + + +V ++I PK+ P I +MR I+ Sbjct: 73 GKVSDEMCLERGITDSSEYLREALKYLV--DVKVVHVSISIECSYPKISPKIAEMRKSIS 130 Query: 118 EDLGCHMDDVNVKATTTEKLGFTGRGEGI 146 E LG + V + ATT E L G+G+G+ Sbjct: 131 ELLGIPENCVGITATTGEGLTAFGQGKGV 159 >UniRef50_Q0PH58 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (Fragment) n=1 Tax=Toxoplasma gondii RepID=Q0PH58_TOXGO Length = 91 Score = 71.6 bits (174), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 42/89 (47%), Positives = 57/89 (64%), Gaps = 3/89 (3%) Query: 33 AHSDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAK--GYT 90 AHSDGDV LHA+ DA+ GA ALGDIG+ F D++PAF+G S L+ A ++AK + Sbjct: 1 AHSDGDVLLHAVCDAVFGAFALGDIGEHFSDSNPAFRGMSSSILVARALEIVRAKHPDWR 60 Query: 91 LGNVDVTIIAQAPKM-LPHIPQMRVFIAE 118 LG+VD T++ A K +MR +AE Sbjct: 61 LGSVDATVVFDAMKFGRARKQKMRENLAE 89 >UniRef50_C2BUI0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Mobiluncus RepID=C2BUI0_9ACTO Length = 195 Score = 69.3 bits (168), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 63/161 (39%), Positives = 87/161 (54%), Gaps = 8/161 (4%) Query: 1 MRIGHGFDVHAFGGEGPII-----IGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALG 55 R+G GFD H F P++ +G + P L HSDGDVA HALTDALL AA LG Sbjct: 37 FRVGQGFDAHRFAAGAPVVGRPLRVGTLSFPDHAPLEGHSDGDVAAHALTDALLAAAGLG 96 Query: 56 DIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVF 115 D+G F + P + GA LR A R + G+ + N VT++ Q P++ H + Sbjct: 97 DLGTNFGVSRPEYAGASGEVFLRAAMRMLHETGWVVVNASVTVVGQEPRLGSHYAEAEAA 156 Query: 116 IAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 + L V+ ATTT+++GFTG EG+A A+ LL + Sbjct: 157 LGNILAA---PVSFSATTTDRMGFTGNKEGLAALAICLLRR 194 >UniRef50_B7GT04 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=14 Tax=Bifidobacterium RepID=ISPF_BIFLI Length = 174 Score = 69.3 bits (168), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 70/170 (41%), Positives = 88/170 (51%), Gaps = 20/170 (11%) Query: 3 IGHGFDVHAFGGEGP---IIIGGVRIP------------YEKGLLAHSDGDVALHALTDA 47 IG GFD H F G + I G+ P YE G+ SDGDVA HAL DA Sbjct: 8 IGQGFDAHRFAPAGSGRELWIAGLYWPVPDSCSEADAARYE-GIEGDSDGDVAAHALIDA 66 Query: 48 LLGAAALGDIGKLFP-DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKML 106 LL AA LGDIG LF D G ++L+E + + GYT + V II PK+ Sbjct: 67 LLAAARLGDIGSLFGVGADAHGAGRHGIDMLQEVVAHLASNGYTPASASVAIIGNRPKIG 126 Query: 107 PHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 + ++ +GC V+V ATTT+ +GFTGRGEGIA A AL+ K Sbjct: 127 TRRAEAEAALSAAVGC---PVSVTATTTDHMGFTGRGEGIAAIANALVEK 173 >UniRef50_C5BMS2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Teredinibacter turnerae T7901 RepID=C5BMS2_TERTT Length = 157 Score = 68.9 bits (167), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 44/132 (33%), Positives = 69/132 (52%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIGHG +++GGV + GL +DGD+ L A+ DAL GAA LG+ L Sbjct: 1 MRIGHGIVCAQRTQARKLVLGGVYLEPGFGLAIMNDGDLLLAAVGDALAGAAGLGNFVSL 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 + T P FK A +R LL+ +++KG N+D+++ + + M+ IA+ L Sbjct: 61 YDLTSPDFKHASTRSLLQMLATSLRSKGLRTVNLDISLCGRDLIFNAYRDDMQASIADAL 120 Query: 121 GCHMDDVNVKAT 132 G +N+K + Sbjct: 121 GIDATRINLKLS 132 >UniRef50_B7IFV0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Thermosipho africanus TCF52B RepID=B7IFV0_THEAB Length = 332 Score = 65.9 bits (159), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 45/140 (32%), Positives = 70/140 (50%), Gaps = 11/140 (7%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G G+D H + +I+GGV I + GL HSD DV +H++ D+ +G + DIG+LFP+ Sbjct: 184 GIGWDTHPIKKDRKLILGGVEIESDIGLDGHSDADVLIHSIVDSFVGVSLKKDIGELFPE 243 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTII---------AQAPKMLPHIPQMRV 114 D KG S +L + ++ G+ +VD +I A+ K L I V Sbjct: 244 KDVP-KGISSVFILENVLKSMKENGFFPESVDCVLITDFRLGKYRAEISKNLEKIINCPV 302 Query: 115 FIAEDLGCHM-DDVNVKATT 133 I G ++ + N+KA T Sbjct: 303 SIKFKTGNNVYPETNLKAMT 322 >UniRef50_A7HN63 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Fervidobacterium nodosum Rt17-B1 RepID=A7HN63_FERNB Length = 326 Score = 65.5 bits (158), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 35/97 (36%), Positives = 53/97 (54%), Gaps = 1/97 (1%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G G+D H ++IGGV I GLL HSD DV HA+ D+++G DIG LFP+ Sbjct: 178 GIGWDTHPLVESRNLVIGGVDIESNMGLLGHSDADVLTHAIIDSIVGITHKKDIGVLFPE 237 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIA 100 + K S ++L E + + + G+ ++D II+ Sbjct: 238 NESN-KDRRSIDMLEEVTKYVISSGFFPSSIDCVIIS 273 >UniRef50_UPI0001B44793 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Listeria monocytogenes FSL J1-208 RepID=UPI0001B44793 Length = 62 Score = 62.0 bits (149), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 31/59 (52%), Positives = 42/59 (71%) Query: 98 IIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 ++ ++ KM P++ Q+++ IAE L VNVKATTTEKLGFTGR EGIA A+ L+ K Sbjct: 4 LLLKSQKMAPYVEQIKLRIAELLHADSAQVNVKATTTEKLGFTGREEGIASLAIVLIEK 62 >UniRef50_Q0PH60 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (Fragment) n=1 Tax=Eimeria tenella RepID=Q0PH60_EIMTE Length = 87 Score = 56.6 bits (135), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 35/86 (40%), Positives = 47/86 (54%) Query: 57 IGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFI 116 IG+ FPDT KG +SRE + A A GYT+ VDVT++ Q P++ QM + Sbjct: 2 IGQPFPDTAAENKGRNSREFVAAAVAAAAAAGYTVAQVDVTLMLQRPRISSKKQQMIDTL 61 Query: 117 AEDLGCHMDDVNVKATTTEKLGFTGR 142 A LG V++KA T E +G GR Sbjct: 62 AAALGISSSKVSLKAKTGEGVGPVGR 87 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_D1PLD9 IspD/IspF enzyme n=2 Tax=Firmicutes RepID=D1PLD9... 260 1e-68 UniRef50_D2RJ59 2C-methyl-D-erythritol 2,4-cyclodiphosphate synt... 254 7e-67 UniRef50_C6LHN9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 248 5e-65 UniRef50_B2K578 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 247 1e-64 UniRef50_C4Z8W9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 246 2e-64 UniRef50_Q1LLZ4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 245 3e-64 UniRef50_C4Z3N3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 244 5e-64 UniRef50_Q18CD3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 244 6e-64 UniRef50_Q21YT7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 244 9e-64 UniRef50_Q9CAK8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 241 6e-63 UniRef50_Q7VFU3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 241 9e-63 UniRef50_B0TYX5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 240 1e-62 UniRef50_A8LKV5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 239 2e-62 UniRef50_Q87DY3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 239 2e-62 UniRef50_C9KNS3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 239 2e-62 UniRef50_C6XJQ8 2C-methyl-D-erythritol 2,4-cyclodiphosphate synt... 239 3e-62 UniRef50_Q2NAE1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 239 3e-62 UniRef50_B7H1F3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 238 3e-62 UniRef50_UPI000197A0EE bifunctional 2-C-methyl-D-erythritol 4-ph... 238 4e-62 UniRef50_A9KSM7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 238 5e-62 UniRef50_Q487E8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 238 5e-62 UniRef50_Q2IW23 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 238 6e-62 UniRef50_Q6ARN9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 237 6e-62 UniRef50_Q1QU74 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 236 2e-61 UniRef50_A4WSL4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 236 3e-61 UniRef50_B2JA49 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 235 4e-61 UniRef50_C0R0Y4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 235 4e-61 UniRef50_A5VQP4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 234 1e-60 UniRef50_Q2K8V5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 232 2e-60 UniRef50_B6YRV8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 232 3e-60 UniRef50_Q5GSM7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 231 6e-60 UniRef50_C3XLN9 Bifunctional enzyme ispD/ispF n=1 Tax=Helicobact... 231 9e-60 UniRef50_A6U8F8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 230 1e-59 UniRef50_A0RN28 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 230 1e-59 UniRef50_Q1QM99 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 229 2e-59 UniRef50_Q0BTD5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 229 3e-59 UniRef50_C5EY67 Bifunctional enzyme ispD/ispF n=2 Tax=Helicobact... 229 3e-59 UniRef50_C8PHW7 Bifunctional enzyme IspD/ispF n=1 Tax=Campylobac... 228 4e-59 UniRef50_C9LKY7 IspD/IspF enzyme n=1 Tax=Dialister invisus DSM 1... 227 8e-59 UniRef50_B1GYT3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 227 9e-59 UniRef50_C1FJN6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 227 1e-58 UniRef50_C0QQE6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 227 1e-58 UniRef50_Q30QG7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 226 2e-58 UniRef50_D1BMU2 2-C-methyl-D-erythritol 4-phosphate cytidylyltra... 226 3e-58 UniRef50_A9BVX5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 225 3e-58 UniRef50_B9JW91 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 225 4e-58 UniRef50_Q1AU09 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 224 6e-58 UniRef50_C7GYL8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 222 2e-57 UniRef50_B6DX86 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 222 2e-57 UniRef50_B8E112 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 222 2e-57 UniRef50_Q7MQW9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 222 3e-57 UniRef50_Q0APQ6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 222 4e-57 UniRef50_B1I0S9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 220 1e-56 UniRef50_Q2GER2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 219 3e-56 UniRef50_Q9ZM19 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 218 4e-56 UniRef50_D1CCF0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 217 1e-55 UniRef50_Q4FM31 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 216 2e-55 UniRef50_A3ZYT9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 216 2e-55 UniRef50_Q5P993 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 216 3e-55 UniRef50_C3XI64 Bifunctional 2-C-methyl-D-erythritol 4-phosphate... 215 3e-55 UniRef50_B8D9J7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 215 4e-55 UniRef50_C6BS25 2-C-methyl-D-erythritol 4-phosphate cytidylyltra... 215 5e-55 UniRef50_Q310X3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 214 5e-55 UniRef50_D1B5E2 2C-methyl-D-erythritol 2,4-cyclodiphosphate synt... 212 3e-54 UniRef50_B0SAT2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 212 3e-54 UniRef50_A5V2U9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 211 1e-53 UniRef50_B2URI3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 210 1e-53 UniRef50_A7HDA2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 208 4e-53 UniRef50_B9KAZ0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 207 7e-53 UniRef50_B8CD73 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 207 1e-52 UniRef50_Q2RFM1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 206 2e-52 UniRef50_Q1MR76 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 205 3e-52 UniRef50_C1F762 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 205 4e-52 UniRef50_Q73KC6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 205 4e-52 UniRef50_Q1IVA8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 201 5e-51 UniRef50_B2KDX1 2-C-methyl-D-erythritol 4-phosphate cytidylyltra... 200 1e-50 UniRef50_B7FYU1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 199 2e-50 UniRef50_B1L8F8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 199 3e-50 UniRef50_A8F4L5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 198 4e-50 UniRef50_B1Q2Q5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 198 5e-50 UniRef50_C4RE02 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 197 8e-50 UniRef50_C4XSW4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 197 9e-50 UniRef50_Q4MZY9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 197 1e-49 UniRef50_C8R0Y1 2-C-methyl-D-erythritol 4-phosphate cytidylyltra... 191 7e-48 UniRef50_D0RP30 Bifunctional enzyme IspD/ispF n=1 Tax=alpha prot... 190 9e-48 UniRef50_Q72HP8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 189 4e-47 UniRef50_B3L0R0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 186 2e-46 UniRef50_Q1QBM3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 186 2e-46 UniRef50_B4U9N6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 186 2e-46 UniRef50_A5CTY4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 185 4e-46 UniRef50_B6KAQ3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 184 1e-45 UniRef50_P62368 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 183 1e-45 UniRef50_B1VS88 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 183 2e-45 UniRef50_B1VIQ0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 182 4e-45 UniRef50_C1TMK1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 178 6e-44 UniRef50_B9RCH5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 176 2e-43 UniRef50_C1CZ33 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 172 4e-42 UniRef50_C9M692 2-C-methyl-D-erythritol 4-phosphate cytidylyltra... 172 4e-42 UniRef50_Q14PQ0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 172 5e-42 UniRef50_A9BHL8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 171 6e-42 UniRef50_C5CGG7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 170 1e-41 UniRef50_B0BC71 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 170 2e-41 UniRef50_C7M1Q8 2-C-methyl-D-erythritol 4-phosphate cytidylyltra... 165 3e-40 UniRef50_B8I5R3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 162 4e-39 UniRef50_Q83NK3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 159 2e-38 UniRef50_A6LJL2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 155 3e-37 UniRef50_A7HN63 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 155 4e-37 UniRef50_Q7NC56 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 153 1e-36 UniRef50_B7IFV0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 150 1e-35 UniRef50_Q8EUA4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 146 3e-34 UniRef50_C5BMS2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 145 3e-34 UniRef50_A7AVQ2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 141 7e-33 UniRef50_UPI0001913A58 2-C-methyl-D-erythritol 2,4-cyclodiphosph... 138 4e-32 UniRef50_B5Y8V5 Bifunctional enzyme IspD/ispF n=1 Tax=Coprotherm... 131 7e-30 UniRef50_C2BUI0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 122 5e-27 UniRef50_B7GT04 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 118 4e-26 UniRef50_Q0PH58 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 115 6e-25 UniRef50_Q0PH60 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 96 3e-19 UniRef50_UPI0001B44793 2-C-methyl-D-erythritol 2,4-cyclodiphosph... 82 4e-15 Sequences not found previously or not previously below threshold: UniRef50_Q49436 Uncharacterized protein MG459 n=2 Tax=Mycoplasma... 76 3e-13 UniRef50_UPI0001699D05 tRNA pseudouridine synthase D n=1 Tax=End... 49 4e-05 >UniRef50_D1PLD9 IspD/IspF enzyme n=2 Tax=Firmicutes RepID=D1PLD9_9FIRM Length = 400 Score = 260 bits (666), Expect = 1e-68, Method: Composition-based stats. Identities = 97/155 (62%), Positives = 114/155 (73%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIGHG+DVH +I+GGV IPYEKGLL HSD DV LHA+ DA+LGAAALGDIGK Sbjct: 245 MRIGHGYDVHQLVEGRKLILGGVEIPYEKGLLGHSDADVLLHAIMDAVLGAAALGDIGKH 304 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTDPA+KGADS L R ++ +GY++GN+D TI+ QAPK+ PHIP MR IAE Sbjct: 305 FPDTDPAYKGADSLALTRAVAGLVREQGYSVGNIDSTILCQAPKLAPHIPAMRAHIAEAF 364 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 G +D V+VKATT E +GFTG G GIA AV LL Sbjct: 365 GIPLDAVSVKATTEEHMGFTGEGRGIAAHAVVLLE 399 >UniRef50_D2RJ59 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RJ59_ACIFE Length = 395 Score = 254 bits (650), Expect = 7e-67, Method: Composition-based stats. Identities = 95/156 (60%), Positives = 115/156 (73%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 RIG G+DVH P+I+ GV +P+++GL HSD DVALHAL DALLGAA +GDIG+L Sbjct: 240 FRIGSGYDVHRLVEGRPLILCGVTVPWDRGLDGHSDADVALHALMDALLGAAGMGDIGRL 299 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD A+ GADSR+LL +++A G+ + NVDVTIIAQ PK+ P+ P M + DL Sbjct: 300 FPDTDDAYLGADSRKLLAAVLEKLRAAGWQVNNVDVTIIAQRPKLAPYEPAMLENLLTDL 359 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 G D VNVKATTTEKLGFTGRGEGIA EAVA L + Sbjct: 360 GLPRDAVNVKATTTEKLGFTGRGEGIAAEAVASLTR 395 >UniRef50_C6LHN9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Bryantella formatexigens DSM 14469 RepID=C6LHN9_9FIRM Length = 226 Score = 248 bits (634), Expect = 5e-65, Method: Composition-based stats. Identities = 87/155 (56%), Positives = 109/155 (70%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MR+G G+DVH +I+ GV IPYEKGLL HSD DVA+HA+ DALLGAAALGDIGK Sbjct: 40 MRVGMGYDVHRLTEGRKLILCGVEIPYEKGLLGHSDADVAVHAIMDALLGAAALGDIGKH 99 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD + G S LL+ ++ Y + N+D TIIAQ PK+LP++PQM +AE L Sbjct: 100 FPDTDAQYAGISSILLLKRVGDLLEENNYIIENIDATIIAQRPKLLPYMPQMVKNVAEAL 159 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 G + VN+KATT E LGFTG GEGI+ +A+ LL+ Sbjct: 160 GIEENQVNIKATTEEGLGFTGNGEGISAQAICLLM 194 >UniRef50_B2K578 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=32 Tax=Bacteria RepID=ISPF_YERPB Length = 162 Score = 247 bits (631), Expect = 1e-64, Method: Composition-based stats. Identities = 135/161 (83%), Positives = 144/161 (89%), Gaps = 2/161 (1%) Query: 1 MRIGHGFDVHAFGGEG--PIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIG 58 MRIGHGFDVH FG G P+IIGGVRIPYEKGLLAHSDGDVALHA TDALLGAAALGDIG Sbjct: 1 MRIGHGFDVHKFGENGSGPLIIGGVRIPYEKGLLAHSDGDVALHAATDALLGAAALGDIG 60 Query: 59 KLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAE 118 KLFPDTDPAFKGADSR LLREA+R I AKGY LGN+D+TIIAQAPKM PHIPQMRV +AE Sbjct: 61 KLFPDTDPAFKGADSRGLLREAYRCILAKGYKLGNLDITIIAQAPKMAPHIPQMRVNLAE 120 Query: 119 DLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 DL CHMDD+NVKATTTE+LGFTGRGEGIACEAV LL+ + Sbjct: 121 DLQCHMDDINVKATTTEQLGFTGRGEGIACEAVVLLVNVEQ 161 >UniRef50_C4Z8W9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=38 Tax=cellular organisms RepID=ISPF_EUBR3 Length = 177 Score = 246 bits (628), Expect = 2e-64, Method: Composition-based stats. Identities = 85/154 (55%), Positives = 107/154 (69%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MR+G G+DVH +I+GGV++P+ GLL HSD DV LHA+ DALLGAAALGDIGK Sbjct: 1 MRVGMGYDVHKLVEGRDLILGGVKVPHTLGLLGHSDADVLLHAIMDALLGAAALGDIGKH 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTDPA++G S +LL I KGY + N+D T+IAQ PK+ P+I QM +A+ L Sbjct: 61 FPDTDPAYEGISSLKLLEHVRDLIAKKGYVIENIDATVIAQKPKLRPYIEQMEQNVADTL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 + VN+KATT E LGFTGR EGIA +A+ L Sbjct: 121 QIAKEQVNIKATTEEWLGFTGREEGIASQAICSL 154 >UniRef50_Q1LLZ4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=60 Tax=Bacteria RepID=ISPF_RALME Length = 168 Score = 245 bits (627), Expect = 3e-64, Method: Composition-based stats. Identities = 93/156 (59%), Positives = 113/156 (72%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIG G+DVHA +I+GGV IP+++GLL HSD D LHA+TDAL GAAALGDIG+ Sbjct: 6 IRIGQGYDVHALVPGRKLILGGVDIPHDRGLLGHSDADALLHAVTDALFGAAALGDIGRH 65 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTDP F GADSR LLREA RR++ GY +GNVD T+IAQ PK+ PHI M +AEDL Sbjct: 66 FPDTDPNFAGADSRVLLREAVRRVREAGYEIGNVDATVIAQKPKLAPHISGMVANLAEDL 125 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 G + NVKA T EKLGF G+ EGI +A L+ + Sbjct: 126 GLPVTRCNVKAKTNEKLGFEGKEEGIVAQAAVLIYR 161 >UniRef50_C4Z3N3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=426 Tax=cellular organisms RepID=ISPF_EUBE2 Length = 183 Score = 244 bits (625), Expect = 5e-64, Method: Composition-based stats. Identities = 90/158 (56%), Positives = 109/158 (68%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MR+G G+DVH + +I+GGV IPYE GLL HSD DV LHA+ DALLGAAALGDIGK Sbjct: 1 MRVGMGYDVHKLVKDRKLIMGGVEIPYELGLLGHSDADVLLHAIMDALLGAAALGDIGKH 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD +KG S +LL E ++I Y + N+D TIIAQ PKM P+I MR IA+ L Sbjct: 61 FPDTDDRYKGISSIKLLEEVGKKIDEANYIIENIDATIIAQKPKMRPYIDDMRKNIADAL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 +D VNVKATT E LGFTG GEGI+ +A+ L + Sbjct: 121 KIDVDRVNVKATTEEGLGFTGSGEGISSQAICSLNSVS 158 >UniRef50_Q18CD3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=116 Tax=Bacteria RepID=ISPF_CLOD6 Length = 161 Score = 244 bits (625), Expect = 6e-64, Method: Composition-based stats. Identities = 87/159 (54%), Positives = 117/159 (73%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIG G+DVH + +IIGGV IP++KGLL HSD DV +HA+ D++LGA ALGDIGK Sbjct: 1 MRIGLGYDVHKLTEDRKLIIGGVEIPHDKGLLGHSDADVLIHAIMDSILGALALGDIGKH 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD +KGADS +LL + I +KGY +GN+D TIIAQ+PKM P+I MR I++ L Sbjct: 61 FPDTDEEYKGADSMKLLEHVYNLITSKGYKIGNIDSTIIAQSPKMAPYIESMRSNISKVL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 +D++N+KATT E LGFTG +GIA +++ LL+ ++ Sbjct: 121 NTDIDNINIKATTEEGLGFTGAKQGIASQSICLLLLTSQ 159 >UniRef50_Q21YT7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=175 Tax=Bacteria RepID=ISPDF_RHOFD Length = 418 Score = 244 bits (623), Expect = 9e-64, Method: Composition-based stats. Identities = 91/156 (58%), Positives = 110/156 (70%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 RIG G+D+HA +++GGV IPY GLL HSD DV LHA+TDALLGAAALGDIG Sbjct: 261 FRIGEGWDIHALVAGRKLLLGGVEIPYHLGLLGHSDADVLLHAITDALLGAAALGDIGTH 320 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD FKGADS LL EA RR++AKG+ +GNVD T+IAQAPK++P++ MR IA L Sbjct: 321 FPDTDARFKGADSLVLLTEAARRVRAKGFEIGNVDSTVIAQAPKLMPYMAAMRAQIALAL 380 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 +D VNVKA T EK+G G G+ + A LL K Sbjct: 381 ALEVDQVNVKAKTAEKMGPVGLGQAMEARATVLLRK 416 >UniRef50_Q9CAK8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, chloroplastic n=38 Tax=Viridiplantae RepID=ISPF_ARATH Length = 231 Score = 241 bits (616), Expect = 6e-63, Method: Composition-based stats. Identities = 75/157 (47%), Positives = 101/157 (64%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 RIGHGFD+H P+IIGG+ IP+++G AHSDGDV LH + DA+LGA L DIG++ Sbjct: 75 FRIGHGFDLHRLEPGYPLIIGGIVIPHDRGCEAHSDGDVLLHCVVDAILGALGLPDIGQI 134 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPD+DP +KGA S ++EA R + GY +GN+D T+I Q PK+ PH +R +++ L Sbjct: 135 FPDSDPKWKGAASSVFIKEAVRLMDEAGYEIGNLDATLILQRPKISPHKETIRSNLSKLL 194 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 G VN+KA T EK+ G IA V LL+K Sbjct: 195 GADPSVVNLKAKTHEKVDSLGENRSIAAHTVILLMKK 231 >UniRef50_Q7VFU3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Campylobacterales RepID=ISPDF_HELHP Length = 389 Score = 241 bits (615), Expect = 9e-63, Method: Composition-based stats. Identities = 77/152 (50%), Positives = 96/152 (63%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 IG+G DVH F + +GGV I G AHSDGDV LHAL+DA+LGA GDIG+ FP Sbjct: 225 IGNGIDVHQFEKNKQMWLGGVEIESPFGFKAHSDGDVVLHALSDAILGAIGGGDIGEWFP 284 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 DTD +K ADS+ +L E + Q+ GY L N D++IIAQ PK+ P+ MR IA L Sbjct: 285 DTDETYKNADSKMMLSEIYTFAQSVGYELYNADISIIAQTPKIAPYKSAMRECIARILRV 344 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 +N+KATTTE LGF GR EG+ EA + Sbjct: 345 PNAHINIKATTTEGLGFVGREEGVCVEACVSM 376 >UniRef50_B0TYX5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=5 Tax=Gammaproteobacteria RepID=ISPF_FRAP2 Length = 159 Score = 240 bits (614), Expect = 1e-62, Method: Composition-based stats. Identities = 89/157 (56%), Positives = 110/157 (70%), Gaps = 1/157 (0%) Query: 1 MRIGHGFDVHAFGGEGP-IIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGK 59 RIGHG+DVH F II+GG+ IPYE GL AHSDGDV +HAL DA+LGA LGDIGK Sbjct: 3 FRIGHGYDVHKFTSTKKNIILGGIEIPYEMGLEAHSDGDVLIHALCDAILGALCLGDIGK 62 Query: 60 LFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAED 119 FPDTD +K DS+ L E + + K Y++ N+D TIIAQAPKMLPHI +M+ +A Sbjct: 63 HFPDTDMEYKNTDSKFFLAEIKKMLDDKEYSISNIDCTIIAQAPKMLPHIEKMKACLASV 122 Query: 120 LGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 L ++ +N+KATTTE+LGF GR EGIA V LL + Sbjct: 123 LEIQINQINIKATTTEQLGFIGRKEGIATHVVCLLNR 159 >UniRef50_A8LKV5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=16 Tax=Alphaproteobacteria RepID=ISPDF_DINSH Length = 400 Score = 239 bits (611), Expect = 2e-62, Method: Composition-based stats. Identities = 71/157 (45%), Positives = 105/157 (66%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G+G+DVH FG +I+ GV +P+++ L+ HSD DV +HA+TDA+ GA GDIG+ Sbjct: 244 IRTGNGYDVHRFGTGDAVILCGVEVPHDRALMGHSDADVGMHAVTDAIYGALGDGDIGQH 303 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA S LR A +GYT+ ++D T++ + PK+ P+ M+ ++E + Sbjct: 304 FPPSDPQWKGAASEIFLRHAVALAAERGYTITHMDCTLVCERPKIGPYHAVMKAKMSELM 363 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 G D V+VKATT+E+LGFTGR EGIA A L++ Sbjct: 364 GLQPDQVSVKATTSERLGFTGREEGIAALATVTLVRT 400 >UniRef50_Q87DY3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=9 Tax=Xylella fastidiosa RepID=ISPF_XYLFT Length = 176 Score = 239 bits (611), Expect = 2e-62, Method: Composition-based stats. Identities = 80/156 (51%), Positives = 109/156 (69%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIG G+DVHAFG +++GGVR+P+ G+LAHSDGDV LHAL DA+LGA LGDIG+ Sbjct: 15 VRIGQGYDVHAFGPSDHVMLGGVRVPHRCGVLAHSDGDVILHALCDAMLGALGLGDIGQH 74 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +D +KGADS +R ++ + + +GNVD T I ++PK+ P++ MR IA L Sbjct: 75 FPPSDVRWKGADSGVFVRHCNLLLRERDWCVGNVDATAICESPKIAPYVNAMREGIARLL 134 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 + V+VKATT+E LGF GRGEG+A + V LL + Sbjct: 135 EVQPECVSVKATTSEGLGFIGRGEGLAAQVVVLLYR 170 >UniRef50_C9KNS3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KNS3_9FIRM Length = 158 Score = 239 bits (611), Expect = 2e-62, Method: Composition-based stats. Identities = 94/155 (60%), Positives = 111/155 (71%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 R G G+DVH +IIGGV IP+ GLL HSD DV LHA++DALLGAAALGDIG+ F Sbjct: 3 RFGMGYDVHRLVEGRKLIIGGVEIPHALGLLGHSDADVLLHAISDALLGAAALGDIGRHF 62 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 PDTDP ++GADS +LL E R + KGY +GNVD TI+AQ PKM IP+M IA LG Sbjct: 63 PDTDPRYEGADSMKLLAEVRRLLAEKGYRIGNVDATIVAQKPKMKDFIPKMNENIATVLG 122 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 +DDVNVKATT EKLGFTG +GI+ AVA + K Sbjct: 123 VSLDDVNVKATTEEKLGFTGAEQGISAYAVAGIEK 157 >UniRef50_C6XJQ8 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XJQ8_HIRBI Length = 387 Score = 239 bits (610), Expect = 3e-62, Method: Composition-based stats. Identities = 80/154 (51%), Positives = 103/154 (66%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 RIG+G+DVHAF + + G+ IP+ L HSD DVA HALTDA+ GA A GDIG F Sbjct: 231 RIGNGYDVHAFEDGQSVTLCGLEIPHSASLKGHSDADVAWHALTDAIYGALAEGDIGTHF 290 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 P +D +KGA S+ L+ A +KG+ + N D+TII +APK+ PH MR ++ LG Sbjct: 291 PPSDVKWKGAASKVFLKHAVELADSKGFMIANADITIICEAPKIKPHSMTMRDITSKILG 350 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 +D V+VKATTTEKLGFTGR EGIA +A LL+ Sbjct: 351 IPLDRVSVKATTTEKLGFTGRKEGIAAQASVLLV 384 >UniRef50_Q2NAE1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=7 Tax=Bacteria RepID=ISPDF_ERYLH Length = 386 Score = 239 bits (610), Expect = 3e-62, Method: Composition-based stats. Identities = 80/157 (50%), Positives = 106/157 (67%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R+G GFDVH + +GG+R+ ++KGL HSD DVALHA+ DALLGA GDIG Sbjct: 226 VRVGTGFDVHKLEAGEELWLGGIRLEHDKGLAGHSDADVALHAIVDALLGAIGKGDIGDH 285 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA S + A + + GY +GN+D+TII +AP++ PH M IAE L Sbjct: 286 FPPSDPQWKGAASSAFIEHAAKLVDEAGYRVGNIDLTIICEAPRIGPHRDAMGQRIAELL 345 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 D ++VKATTTEKLGFTGRGEGIA +A A +++ Sbjct: 346 ATSPDAISVKATTTEKLGFTGRGEGIAAQAAATVVRK 382 >UniRef50_B7H1F3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=15 Tax=Bacteria RepID=ISPF_ACIB3 Length = 160 Score = 238 bits (609), Expect = 3e-62, Method: Composition-based stats. Identities = 85/154 (55%), Positives = 108/154 (70%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIG G DVHAF + + GV+IP+ GL AHSDGDV LHAL DALLGA ALGDIG+ Sbjct: 5 IRIGQGMDVHAFEEGNFVTLAGVQIPHTHGLKAHSDGDVVLHALCDALLGALALGDIGQH 64 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTDP FKGADSR LL+ ++ I +GY L N D+T+ + PK+ + +MR IA+ L Sbjct: 65 FPDTDPEFKGADSRVLLKHVYQLILDRGYHLNNADITVACERPKLAKYNLEMRQSIADVL 124 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 ++ +++KATTTEKLGFTGR EGI A L+ Sbjct: 125 NVDLNQISIKATTTEKLGFTGRQEGILATATVLI 158 >UniRef50_UPI000197A0EE bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein n=1 Tax=Helicobacter cinaedi CCUG 18818 RepID=UPI000197A0EE Length = 401 Score = 238 bits (608), Expect = 4e-62, Method: Composition-based stats. Identities = 76/152 (50%), Positives = 103/152 (67%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 +G+G DVH+F + +GGV+I G AHSDGDVALHAL+DA+LGA GDIG+ FP Sbjct: 227 VGNGIDVHSFEDNKEMWLGGVKIESSFGFKAHSDGDVALHALSDAILGAIGGGDIGQWFP 286 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 D++ A+K ADS++LL+ + + + GY L NVD++I+AQ PK+ P+ QMR IA L Sbjct: 287 DSNEAYKNADSKKLLQHIYDFVLSVGYELHNVDISIMAQTPKIAPYKSQMRECIARILHL 346 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 VN+KATTTE LGF GR EG+ +A + Sbjct: 347 PKSRVNIKATTTESLGFVGRKEGVCVQASVSM 378 >UniRef50_A9KSM7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=5 Tax=Bacteria RepID=A9KSM7_CLOPH Length = 192 Score = 238 bits (608), Expect = 5e-62, Method: Composition-based stats. Identities = 86/154 (55%), Positives = 106/154 (68%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIG G+DVH +IIGGV +PYEKGLL HSD DV +HA+ DA+LGAAALGDIGK Sbjct: 1 MRIGMGYDVHKLVEGRDLIIGGVTVPYEKGLLGHSDADVLVHAIMDAILGAAALGDIGKH 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDT ++G S LL + ++ + Y +GN+D TIIAQ PKM +IPQM IA+ L Sbjct: 61 FPDTSKEYEGVSSIVLLEKVKELVEKECYIIGNIDATIIAQRPKMAQYIPQMVTNIAKTL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 VNVKATT E LGFTG G+GI+ +A+ LL Sbjct: 121 HISEKQVNVKATTEEGLGFTGSGDGISAQAICLL 154 >UniRef50_Q487E8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=49 Tax=Bacteria RepID=ISPF_COLP3 Length = 170 Score = 238 bits (608), Expect = 5e-62, Method: Composition-based stats. Identities = 96/155 (61%), Positives = 118/155 (76%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIGHGFDVH FGG+GP+++GGV+IP+E G +AHSDGDVA+HAL DA+LGA L DIG Sbjct: 1 MRIGHGFDVHKFGGKGPLVLGGVKIPFELGFIAHSDGDVAIHALCDAILGALCLADIGNH 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD ++ SR LLR + KG+ LGN D+TI+AQAPKM PH+ MR ++EDL Sbjct: 61 FPDTDGQYENISSRILLRHVVSLMTDKGFQLGNADITIVAQAPKMAPHLVAMRTCLSEDL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 ++ VNVKATTTEKLG+TGR EGI+ AV LLI Sbjct: 121 KTTIEQVNVKATTTEKLGYTGRKEGISVHAVVLLI 155 >UniRef50_Q2IW23 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=10 Tax=Alphaproteobacteria RepID=ISPDF_RHOP2 Length = 401 Score = 238 bits (608), Expect = 6e-62, Method: Composition-based stats. Identities = 80/155 (51%), Positives = 105/155 (67%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G G+DVHAFG + + G+++P+ +G LAHSDGDV LHAL DA+LGA A GDIG Sbjct: 234 IRTGTGYDVHAFGDGDHVWLCGLKVPHNRGFLAHSDGDVGLHALVDAILGALADGDIGSH 293 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP TDP +KGA S + L+ A R+ A+G + N++VT+I + PK+ P MR IAE Sbjct: 294 FPPTDPQWKGAASDKFLKYAVDRVAARGGRIANLEVTMICERPKIGPLRDPMRQRIAEIT 353 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 G + V VKATT+E+LGFTGR EGIA A A + Sbjct: 354 GVPVSRVAVKATTSERLGFTGREEGIAATASATIR 388 >UniRef50_Q6ARN9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=4 Tax=Proteobacteria RepID=ISPDF_DESPS Length = 386 Score = 237 bits (607), Expect = 6e-62, Method: Composition-based stats. Identities = 81/156 (51%), Positives = 106/156 (67%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIGHGFD H + +I+GGV IPY GL HSD DV +HAL DALLGA GDIG+ Sbjct: 231 IRIGHGFDAHQLVEKRRLILGGVEIPYHLGLAGHSDADVLVHALCDALLGAIGAGDIGRH 290 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPD+ AFK S LL +++ Y +GN D+++I QAPK+ P++ QM+ IA Sbjct: 291 FPDSSDAFKDIYSIRLLESVMQKVGELNYKIGNADISVICQAPKLAPYLKQMQEIIATSC 350 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 C + D+N+KATTTEK+G+TGRGEGI+C AV LL + Sbjct: 351 ACQISDINIKATTTEKMGYTGRGEGISCHAVVLLQQ 386 >UniRef50_Q1QU74 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=14 Tax=Bacteria RepID=ISPF_CHRSD Length = 162 Score = 236 bits (603), Expect = 2e-61, Method: Composition-based stats. Identities = 101/155 (65%), Positives = 118/155 (76%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIGHGFDVH FG ++IGGVRIPY +G +AHSDGDV LHA+ DALLGA ALGDIG+ Sbjct: 3 LRIGHGFDVHRFGDGDHLMIGGVRIPYVQGFVAHSDGDVLLHAICDALLGACALGDIGRH 62 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD A+ GADSR+LLR + A GY + N+D T+IAQAP+M HIP MR IAEDL Sbjct: 63 FPDTDAAWAGADSRDLLRHVHTLVMAAGYAVANLDATVIAQAPRMAEHIPAMRACIAEDL 122 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 VNVKATT+E+LGFTGR EGIA EAV LL+ Sbjct: 123 DLDTTAVNVKATTSERLGFTGRKEGIAAEAVVLLM 157 >UniRef50_A4WSL4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=6 Tax=Rhodobacterales RepID=ISPF_RHOS5 Length = 159 Score = 236 bits (602), Expect = 3e-61, Method: Composition-based stats. Identities = 86/157 (54%), Positives = 111/157 (70%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G+GFDVHAFG + + GVR+P+ +GL+ HSD DV +HALTDA+ GA A GDIG Sbjct: 3 IRTGNGFDVHAFGPGDHVWLCGVRVPHHRGLIGHSDADVGMHALTDAIYGALAEGDIGVH 62 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA SR L A RI A+G+TL N DVT+I + PK+ P P MR +A + Sbjct: 63 FPPSDPQWKGAASRIFLEHAMGRIAARGFTLANCDVTLICERPKIGPMAPAMREALAAIM 122 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 G + ++VKATT+EKLGFTGR EGIAC A A L++A Sbjct: 123 GVEVGRISVKATTSEKLGFTGREEGIACIATATLLQA 159 >UniRef50_B2JA49 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=7 Tax=Bacteria RepID=ISPF_NOSP7 Length = 160 Score = 235 bits (600), Expect = 4e-61, Method: Composition-based stats. Identities = 75/156 (48%), Positives = 106/156 (67%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIG+G+D+H + +I+GG++IP+E GLL HSD DV HA+ DA+LGA +LGDIG Sbjct: 4 IRIGNGYDIHQLVSDRVLILGGIQIPHELGLLGHSDADVLTHAIMDAMLGALSLGDIGHY 63 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP + GADS LL + + I+ +G+ +GN+D ++A+ PK+ PHI MR +A L Sbjct: 64 FPPSDPKWAGADSLVLLNQVHQLIRDRGWQVGNIDSVVVAERPKLKPHIHNMRDKLAAIL 123 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 + + +KATT EKLG GR EGI AV LL+K Sbjct: 124 ELESNQIGIKATTNEKLGPVGREEGICAYAVVLLLK 159 >UniRef50_C0R0Y4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Bacteria RepID=ISPF_BRAHW Length = 158 Score = 235 bits (600), Expect = 4e-61, Method: Composition-based stats. Identities = 73/158 (46%), Positives = 100/158 (63%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIG+G+D HAF +I+ G+ IPYE GL HSD D +HAL D++LGA ALGDIG Sbjct: 1 MRIGYGYDSHAFAENRKLILSGIEIPYELGLKGHSDADAVIHALIDSILGALALGDIGSH 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPD D +KG S LL + ++ K Y + N D+TII + PK+ +I MR +++ L Sbjct: 61 FPDNDSKYKGISSIVLLEKTVSIMEEKNYEISNTDITIILEKPKLRNYIDTMRENLSKIL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 +++V++KA T EK+ GRGEGIA V+LL K Sbjct: 121 KTDIENVSIKAKTNEKMDSIGRGEGIAVHCVSLLKKTK 158 >UniRef50_A5VQP4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=88 Tax=Proteobacteria RepID=ISPDF_BRUO2 Length = 409 Score = 234 bits (597), Expect = 1e-60, Method: Composition-based stats. Identities = 77/155 (49%), Positives = 101/155 (65%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G+G+DVH+F + + GV+IP+E L HSD DVALHALTDALL GDIG Sbjct: 248 IRTGNGYDVHSFEPGDHVTLCGVKIPHEAKLNGHSDADVALHALTDALLATRGAGDIGTH 307 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA SR + A + ++ G + NVDVT+I++APK+ PH M + + L Sbjct: 308 FPPSDPQWKGAASRIFIEHAAKIVREAGGRIANVDVTLISEAPKIGPHRAAMTQALCDML 367 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 G D V++KATT EKLGF GR EGIA A A +I Sbjct: 368 GIAADRVSIKATTNEKLGFVGRREGIAAIATATVI 402 >UniRef50_Q2K8V5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=7 Tax=cellular organisms RepID=ISPDF_RHIEC Length = 406 Score = 232 bits (594), Expect = 2e-60, Method: Composition-based stats. Identities = 74/155 (47%), Positives = 102/155 (65%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G+G+DVH + + GV IP+++ L HSD DVALHALTDALL GDIG Sbjct: 246 VRTGNGYDVHQLEPGDGVTLCGVFIPHDQRLKGHSDADVALHALTDALLATCGAGDIGDH 305 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA S+ + A R ++ +G T+ N DV++IA+APK+ PH MR ++E L Sbjct: 306 FPPSDPQWKGAASKIFIEHAARIVRERGGTIMNADVSLIAEAPKVGPHREAMRARLSEYL 365 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 G ++ +VKATT EK+GF GR EGIA A A ++ Sbjct: 366 GIDIERCSVKATTNEKIGFVGRREGIAAIATATVV 400 >UniRef50_B6YRV8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=4 Tax=Bacteroidales RepID=ISPF_AZOPC Length = 167 Score = 232 bits (592), Expect = 3e-60, Method: Composition-based stats. Identities = 73/154 (47%), Positives = 103/154 (66%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIG G+DVH + +GG++IPYEKGL HSD DV +HAL DALLGAA +G+IG Sbjct: 3 IRIGFGYDVHPLVMNYNLWLGGIKIPYEKGLKGHSDADVLIHALCDALLGAADIGNIGTN 62 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP+T+ + DS+ LL++ I +K Y L N D+T+ + PK+ P IPQM+ +AE + Sbjct: 63 FPNTNKKLRNIDSKILLKQTMSFIYSKNYELNNADITVCIEQPKLNPFIPQMKTCLAEIM 122 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 ++++KATT+EK+GF GR EGIA A L+ Sbjct: 123 QTDKGNISIKATTSEKMGFIGREEGIAVFATVLI 156 >UniRef50_Q5GSM7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=13 Tax=Rickettsiales RepID=ISPDF_WOLTR Length = 405 Score = 231 bits (590), Expect = 6e-60, Method: Composition-based stats. Identities = 73/162 (45%), Positives = 99/162 (61%), Gaps = 5/162 (3%) Query: 2 RIGHGFDVHAFGGEGP-----IIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGD 56 R+G G+D+H F I I GV I Y+ + AHSDGDVA+HA+ DA+LGA GD Sbjct: 240 RVGTGYDIHRFIKAQGKAKSFIKICGVEIEYDMKIEAHSDGDVAIHAVVDAILGALGCGD 299 Query: 57 IGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFI 116 IG FP + P +K +S L A ++ + KGY++ N+D+TI+ + PK+ P+ M+ FI Sbjct: 300 IGAHFPPSFPEWKDRNSSHFLDFAAKKAKEKGYSVSNLDITIVCEEPKISPYKVAMKKFI 359 Query: 117 AEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 ++ L + VNVKATTTEKLG GR EGI A LL K Sbjct: 360 SKTLEIDSEFVNVKATTTEKLGSIGRNEGILAHASVLLYKIA 401 >UniRef50_C3XLN9 Bifunctional enzyme ispD/ispF n=1 Tax=Helicobacter winghamensis ATCC BAA-430 RepID=C3XLN9_9HELI Length = 400 Score = 231 bits (589), Expect = 9e-60, Method: Composition-based stats. Identities = 80/153 (52%), Positives = 96/153 (62%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 +G G D+H I +GG+ I L+AHSDGDV LHAL DA+LGA GDIG+ FP Sbjct: 239 VGIGNDIHTLASGNGITLGGIFIDCPYQLIAHSDGDVCLHALCDAILGAIGAGDIGEWFP 298 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 D DP +KGADS+ELL+ GY+L VD+TI AQ PK+ P M IA+ LG Sbjct: 299 DNDPKYKGADSKELLQRIVDFTYNVGYSLKQVDITIFAQKPKISPFKKIMESQIAKLLGI 358 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 VNVKATTTEKLGF GRGEGI +A +L Sbjct: 359 PNFKVNVKATTTEKLGFVGRGEGIFAQANIVLE 391 >UniRef50_A6U8F8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=12 Tax=Proteobacteria RepID=ISPDF_SINMW Length = 404 Score = 230 bits (588), Expect = 1e-59, Method: Composition-based stats. Identities = 75/158 (47%), Positives = 102/158 (64%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G+G+DVH + + GV IP+++ L HSD DVALHALTDALL GDIG Sbjct: 243 VRTGNGYDVHQLVEGDGVTLCGVFIPHDRKLSGHSDADVALHALTDALLATCGAGDIGDH 302 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA S L A R ++ +G T+ + D+++IA+APK+ PH QMR ++ L Sbjct: 303 FPPSDPRWKGAPSHIFLEHAARIVRERGGTITHADISLIAEAPKVGPHRQQMRESLSAML 362 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 +D +VKATT EKLGF GR EGIA A A ++ A+ Sbjct: 363 AIAIDRCSVKATTNEKLGFVGRNEGIAAIATATVVYAS 400 >UniRef50_A0RN28 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=19 Tax=Campylobacter RepID=ISPDF_CAMFF Length = 372 Score = 230 bits (588), Expect = 1e-59, Method: Composition-based stats. Identities = 82/155 (52%), Positives = 106/155 (68%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 + G+GFDVHAF I + GV+IPY K +AHSDGDVALHAL DALLGAA+ DIG+L Sbjct: 210 IFCGNGFDVHAFKEGDFITLCGVKIPYSKAFIAHSDGDVALHALCDALLGAASAPDIGEL 269 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 +PD D FK DS+ LL+ + I++ G+ + N D+TIIAQ+PK+ P+ M +A+ L Sbjct: 270 YPDNDSKFKDIDSKILLQNSVNLIRSIGFDIINADITIIAQSPKISPYKDAMAKIVADIL 329 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 G + VN+KATTTE LGF GR EGIA A+ L Sbjct: 330 GIPLHKVNIKATTTEHLGFIGRNEGIAANAIVNLK 364 >UniRef50_Q1QM99 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=37 Tax=Alphaproteobacteria RepID=ISPDF_NITHX Length = 403 Score = 229 bits (585), Expect = 2e-59, Method: Composition-based stats. Identities = 79/155 (50%), Positives = 106/155 (68%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G G+DVHAFG +++ GV++P+ +G LAHSDGDV LHAL DA+LGA A GDIG Sbjct: 234 IRTGTGYDVHAFGDGDHVMLCGVKVPHNRGFLAHSDGDVGLHALVDAILGALADGDIGSH 293 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA S + L+ A R+ A+G + N++VT+I + PK+ P MR IAE Sbjct: 294 FPPSDPQWKGAASDKFLKYAVDRVAARGGRIANLEVTMICERPKIGPLRDTMRARIAEIT 353 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 G + + VKATT+E+LGFTGR EGIA A A + Sbjct: 354 GVAISRIAVKATTSERLGFTGREEGIATTASATVR 388 >UniRef50_Q0BTD5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Alphaproteobacteria RepID=ISPDF_GRABC Length = 376 Score = 229 bits (584), Expect = 3e-59, Method: Composition-based stats. Identities = 79/154 (51%), Positives = 106/154 (68%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 RIG G+DVHAF +I+ G+ +P+ +GL HSD DV +HAL DA+ GA A GDIG+ F Sbjct: 220 RIGTGYDVHAFETGRKLILCGIEVPHHQGLAGHSDADVGIHALCDAIYGALAEGDIGRHF 279 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 P T+ ++K ADS LR A RI A+G L N D+T+I + PK+ PH P M +AE LG Sbjct: 280 PPTEASWKDADSARFLRHAAERIAARGGFLANADLTLICEKPKITPHAPAMIARLAELLG 339 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 +D ++VKATT+EKLGFTGR EGIA +A +++ Sbjct: 340 VSIDKISVKATTSEKLGFTGREEGIAAQAAVIIM 373 >UniRef50_C5EY67 Bifunctional enzyme ispD/ispF n=2 Tax=Helicobacter RepID=C5EY67_9HELI Length = 386 Score = 229 bits (584), Expect = 3e-59, Method: Composition-based stats. Identities = 75/152 (49%), Positives = 96/152 (63%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 IG+G D+HA II+GG+ IP + L+AHSDGDV LHA++DA+LG GDIG+ FP Sbjct: 224 IGNGSDIHALKSGNGIILGGISIPCDFELIAHSDGDVCLHAISDAILGGIGAGDIGEWFP 283 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 D + A+K ADS LL++ GY + D+TI AQ PK+ P+ M I+E L Sbjct: 284 DNNNAYKNADSALLLKKIVDFSINVGYQITQADITIFAQKPKLSPYKNAMEKRISEILEI 343 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 + VNVKATTTE LGF GRGEGI +A L Sbjct: 344 PLFSVNVKATTTEHLGFIGRGEGIMVQATLAL 375 >UniRef50_C8PHW7 Bifunctional enzyme IspD/ispF n=1 Tax=Campylobacter gracilis RM3268 RepID=C8PHW7_9PROT Length = 440 Score = 228 bits (583), Expect = 4e-59, Method: Composition-based stats. Identities = 89/152 (58%), Positives = 109/152 (71%), Gaps = 2/152 (1%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G G+DVHA I++GGV+IP E L+AHSDGDVA+HAL DA+ GAA LGDIG+LFPD Sbjct: 277 GTGYDVHALEKGAGIMLGGVQIPCEFALIAHSDGDVAIHALIDAICGAAMLGDIGELFPD 336 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCH 123 +D KGADS+ELLR+ RR++ GY L N D+TIIAQ PK+ + QM+ ++E L C Sbjct: 337 SDAKLKGADSKELLRKVMRRVRGYGYELVNADITIIAQRPKIGAYKAQMQKVLSEILNC- 395 Query: 124 MDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 VNVKATTTE LGFTGR EGIA +A L Sbjct: 396 -ARVNVKATTTEGLGFTGRSEGIAAQAAVSLK 426 >UniRef50_C9LKY7 IspD/IspF enzyme n=1 Tax=Dialister invisus DSM 15470 RepID=C9LKY7_9FIRM Length = 392 Score = 227 bits (580), Expect = 8e-59, Method: Composition-based stats. Identities = 72/156 (46%), Positives = 101/156 (64%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R+G G+D+H F P+ +GG++I GL HSD DV +HA+ DALLGAA L DIG Sbjct: 232 IRVGEGYDIHRFEVSRPLFLGGIKIADSGGLSGHSDADVLIHAIMDALLGAAGLPDIGHF 291 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPD+D F GA S ELL++ R I + Y +GN+D T+IA+ PK+ +I M+ ++ L Sbjct: 292 FPDSDVRFDGACSLELLKQVSRHITKQNYLIGNIDSTVIAEKPKISEYIEAMKAIMSAAL 351 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 + +N+KATT EKLG GRG+GIA A +L + Sbjct: 352 NISKNQINIKATTNEKLGDIGRGKGIAALASVILFR 387 >UniRef50_B1GYT3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=ISPF_UNCTG Length = 160 Score = 227 bits (580), Expect = 9e-59, Method: Composition-based stats. Identities = 72/159 (45%), Positives = 100/159 (62%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 M IG G+D H +I+GGV+I +GL HSD DV +HAL DALLGAA L DIG Sbjct: 1 MYIGFGYDAHRLKKGRELILGGVKILTSEGLDGHSDADVLIHALMDALLGAAGLNDIGHF 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPD DP +K S LL ++ ++ + +++ NVD+T+I +APK+ P I M+ I+ + Sbjct: 61 FPDMDPKYKNVSSISLLESVYKELKKQNFSVNNVDITVIVEAPKICPFIADMKENISRVI 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 + + +KATT EK+GF GRGEGIA AVA + + K Sbjct: 121 ELKRERIGIKATTNEKMGFVGRGEGIAAVAVASISQEKK 159 >UniRef50_C1FJN6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Micromonas sp. RCC299 RepID=C1FJN6_9CHLO Length = 256 Score = 227 bits (580), Expect = 1e-58, Method: Composition-based stats. Identities = 72/164 (43%), Positives = 102/164 (62%), Gaps = 5/164 (3%) Query: 1 MRIGHGFDVHAFG-----GEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALG 55 MR+GHGFD+H + + +GG+++ +++G +AHSDGDV LH + DA+ GA L Sbjct: 60 MRVGHGFDLHRMELLSEMPDLELWLGGIKLEHDRGCVAHSDGDVLLHCVFDAITGALGLP 119 Query: 56 DIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVF 115 DIG+ FPD DP +KG S ++EA R ++ GY +GN+D TIIAQ PK+ PH ++ Sbjct: 120 DIGQCFPDNDPKWKGCTSDVFIKEAVRLMRDSGYEMGNIDCTIIAQRPKISPHKKAIKEN 179 Query: 116 IAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 +A+ L C VNVKA T EK+ G IAC V +L+KA Sbjct: 180 LAKLLECDEGLVNVKAKTHEKVDSLGENRSIACHTVCMLVKARS 223 >UniRef50_C0QQE6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Hydrogenothermaceae RepID=C0QQE6_PERMH Length = 168 Score = 227 bits (579), Expect = 1e-58, Method: Composition-based stats. Identities = 74/158 (46%), Positives = 98/158 (62%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 RIG GFD+H +IIGGV+IP+EKG AHSDGD+ HALTDALLGA GDIG+LF Sbjct: 4 RIGTGFDIHRLEEGRKLIIGGVQIPFEKGFKAHSDGDIFFHALTDALLGAIGYGDIGQLF 63 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 PD+D ++GADS L+EA R ++ KGY + N+D I+ + PK+LP ++ A L Sbjct: 64 PDSDKKWEGADSSIFLKEASRIVKEKGYEIVNIDCYILLERPKLLPFREKIIENTANILQ 123 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 + + +K + EKLG GR E + V LL K Sbjct: 124 IDKNRIFIKGKSYEKLGEIGRSEAGSAHVVVLLRKKRS 161 >UniRef50_Q30QG7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=11 Tax=Epsilonproteobacteria RepID=ISPDF_SULDN Length = 386 Score = 226 bits (577), Expect = 2e-58, Method: Composition-based stats. Identities = 82/152 (53%), Positives = 105/152 (69%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G GFDVHAF +G + +GG++I E G LAHSDGDVA+HAL DALLGAA +GDIG +FPD Sbjct: 228 GVGFDVHAFDDKGEMFLGGIKIDSEYGFLAHSDGDVAIHALIDALLGAAGMGDIGMMFPD 287 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCH 123 D +KGADS+ELL +++ G+ + NVD+TI A+ P++ + MR I+ LG Sbjct: 288 NDVKYKGADSKELLGTLVTKLRHFGFVIVNVDITIAAEKPRIGNYKMAMRKKISSILGID 347 Query: 124 MDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 VN+KATTTEKLGF GRGEG+ A A L Sbjct: 348 AQRVNIKATTTEKLGFIGRGEGVGVIANANLK 379 >UniRef50_D1BMU2 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase n=6 Tax=Bacteria RepID=D1BMU2_VEIPT Length = 391 Score = 226 bits (576), Expect = 3e-58, Method: Composition-based stats. Identities = 67/156 (42%), Positives = 95/156 (60%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MR+G G+D+H P I+GGV+I + G HSD DV +HAL DALLGAA L DIG Sbjct: 233 MRVGFGYDIHQLKAGRPCILGGVQIESDLGPDGHSDADVLIHALMDALLGAAGLRDIGYY 292 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP D +KG S LL + ++ +G N+D+ +I++ PK+ PHI M++ + L Sbjct: 293 FPPEDDQYKGISSMLLLEKVNFLLKERGLQAYNIDIMVISETPKLKPHIDMMKMNLQSIL 352 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 +D +++KATT E LG GR EGIA +AV + + Sbjct: 353 EIPLDRISIKATTNEMLGAIGRREGIAAQAVVSVYE 388 >UniRef50_A9BVX5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Bacteria RepID=A9BVX5_DELAS Length = 162 Score = 225 bits (575), Expect = 3e-58, Method: Composition-based stats. Identities = 89/147 (60%), Positives = 107/147 (72%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 RIG G+DVHA +I+GG+ +P+E GLL HSD DV LHA+TDALLG AALGDIG+ Sbjct: 6 FRIGEGWDVHALVPGRKLILGGIEVPHELGLLGHSDADVLLHAITDALLGGAALGDIGRH 65 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTDP F+GADS LL EA RR++A G +GN+D TIIAQAPK+ PHIP MR IA L Sbjct: 66 FPDTDPEFRGADSLVLLVEAARRVRATGLEIGNIDSTIIAQAPKLAPHIPAMRERIATAL 125 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIA 147 G +D VNVKA T EKLG G+ + + Sbjct: 126 GLALDQVNVKAKTAEKLGPVGQQQAME 152 >UniRef50_B9JW91 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=6 Tax=Alphaproteobacteria RepID=ISPDF_AGRVS Length = 407 Score = 225 bits (574), Expect = 4e-58, Method: Composition-based stats. Identities = 72/155 (46%), Positives = 100/155 (64%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G+G+DVH + + G+ I +++ L HSD DVALHALTDALL GDIG Sbjct: 247 VRTGNGYDVHQLVPGDGVTLCGIFIAHDQALSGHSDADVALHALTDALLATCGAGDIGDH 306 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP ++GA SR L A ++ G T+ N D+++IA+APK+ PH MR ++E L Sbjct: 307 FPPSDPQWRGAASRIFLEHAANIVRDAGGTIMNADISLIAEAPKIGPHRQIMREKLSEIL 366 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 G ++ +VKATT EK+GF GRGEGIA A A ++ Sbjct: 367 GIALERCSVKATTNEKIGFVGRGEGIAAIATATVV 401 >UniRef50_Q1AU09 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=6 Tax=Bacteria RepID=ISPF_RUBXD Length = 165 Score = 224 bits (573), Expect = 6e-58, Method: Composition-based stats. Identities = 84/159 (52%), Positives = 106/159 (66%), Gaps = 4/159 (2%) Query: 2 RIGHGFDVHAFG---GEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIG 58 R+G G DVHAF +++GGVRIP E+GL HSD DV HA+TDALLGAA L DIG Sbjct: 5 RVGLGVDVHAFADPAEGRQLVLGGVRIPSERGLRGHSDADVLAHAVTDALLGAAGLEDIG 64 Query: 59 KLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAE 118 FPDTD F+ ADS LLREA R + G+ + NVD +I + P++ H +MR +A Sbjct: 65 HYFPDTDERFRDADSIWLLREARRIV-GGGWEVVNVDAVVICERPRIREHREKMRENLAA 123 Query: 119 DLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 LG V+V+ TT+E+LGFTGRGEGIA +AV LL +A Sbjct: 124 ALGVEASRVSVRGTTSERLGFTGRGEGIAAQAVCLLERA 162 >UniRef50_C7GYL8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7GYL8_9FIRM Length = 171 Score = 222 bits (568), Expect = 2e-57, Method: Composition-based stats. Identities = 76/156 (48%), Positives = 100/156 (64%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G G+DVH II+GG++IP E + AHSDGDV H++ DA+LGAA LGDIG+ Sbjct: 14 IRTGIGYDVHKLVPGSEIILGGIKIPCEFSIEAHSDGDVLCHSIMDAMLGAAGLGDIGEH 73 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD KGA S ELL++ +++ G + N+D II + PK+ +M+ IA + Sbjct: 74 FPDTDAKLKGASSMELLKDVNDKLKKAGMKVANIDAIIILEKPKISEMKVKMKENIANVI 133 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 M VN+KATTTEKLG GR EGIA +AV L K Sbjct: 134 EIDMGRVNIKATTTEKLGSIGRSEGIASQAVVTLEK 169 >UniRef50_B6DX86 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Guillardia theta RepID=B6DX86_GUITH Length = 225 Score = 222 bits (568), Expect = 2e-57, Method: Composition-based stats. Identities = 76/164 (46%), Positives = 102/164 (62%), Gaps = 5/164 (3%) Query: 1 MRIGHGFDVHAFGG----EGPIIIGGVRIPY-EKGLLAHSDGDVALHALTDALLGAAALG 55 RIGHGFD+H +IGGV++ E G AHSDGDV H++TDA+LGA +L Sbjct: 62 FRIGHGFDIHRLAPLEVAGQGCVIGGVKVENFELGTEAHSDGDVLYHSVTDAILGALSLP 121 Query: 56 DIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVF 115 DIG+L PDTDP +KG DS + L EAW+ + +GY + N+DVT+I + PK+ P +M Sbjct: 122 DIGQLSPDTDPKWKGCDSEKFLAEAWKLMDERGYQVSNLDVTLILERPKVSPIKSRMEDN 181 Query: 116 IAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 ++ L +D VNVKA T EK+ G G +AC AV L+ K K Sbjct: 182 LSRVLKAELDVVNVKARTHEKVDSIGEGRAMACHAVILMEKKAK 225 >UniRef50_B8E112 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Dictyoglomus turgidum DSM 6724 RepID=B8E112_DICTD Length = 164 Score = 222 bits (568), Expect = 2e-57, Method: Composition-based stats. Identities = 71/154 (46%), Positives = 102/154 (66%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R+G G+DVH F + +GG++IP++KGL HSDGDV +HA+ DALLGA+AL DIG Sbjct: 9 IRVGLGYDVHPFEEGRELFLGGIKIPFDKGLKGHSDGDVLIHAIADALLGASALPDIGYF 68 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP D + +G S +L + ++ KG + N+D TIIA+ PK++P ++ ++ L Sbjct: 69 FPVDDKSIEGIPSTIILEKVRDLLKEKGVNIINIDCTIIAEEPKIMPFRDKIIKNLSSIL 128 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 D ++VKATT EKLGF G+ EGIA AVAL+ Sbjct: 129 RIPEDCLSVKATTNEKLGFIGKKEGIAVFAVALV 162 >UniRef50_Q7MQW9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Proteobacteria RepID=ISPDF_WOLSU Length = 379 Score = 222 bits (567), Expect = 3e-57, Method: Composition-based stats. Identities = 78/152 (51%), Positives = 98/152 (64%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G GFDVHAF + + GV IP AHSDGDVA+HAL DALLGAA GDIG+ FPD Sbjct: 216 GSGFDVHAFMEGEGLRLAGVNIPAPVTFKAHSDGDVAIHALIDALLGAAGAGDIGEWFPD 275 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCH 123 +D A+KG DS LL+E + I+ G+ L N D+TI+AQAPK+ P+ M + E + Sbjct: 276 SDLAYKGVDSTLLLQEVIKFIRGIGFELINADLTIMAQAPKLSPYKEAMERRLGEVMEVS 335 Query: 124 MDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 ++VKATTTE LGF GR EG+A A +L Sbjct: 336 RQRISVKATTTESLGFVGRKEGVAVSAQVVLK 367 >UniRef50_Q0APQ6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=10 Tax=Proteobacteria RepID=ISPDF_MARMM Length = 383 Score = 222 bits (566), Expect = 4e-57, Method: Composition-based stats. Identities = 73/151 (48%), Positives = 94/151 (62%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 G G+DVH + + GV I GL+ HSD D LHALTDA+LGAA GDIG+ FP Sbjct: 228 TGQGYDVHRLEPADVMWLCGVEIRAGLGLIGHSDADAGLHALTDAVLGAAGAGDIGQHFP 287 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 +DP +KGA S L A + ++ G L + D+T+IA+ PK+ PH MR +AE G Sbjct: 288 PSDPQWKGAASDAFLLHAIKLLKQVGGELVHADITLIAERPKIGPHRDAMRARVAELTGL 347 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVAL 153 VN+ ATTTEKLGFTGRGEG+A +A+ Sbjct: 348 PEKRVNIAATTTEKLGFTGRGEGLAAQAIVT 378 >UniRef50_B1I0S9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=9 Tax=Bacteria RepID=ISPDF_DESAP Length = 394 Score = 220 bits (561), Expect = 1e-56, Method: Composition-based stats. Identities = 68/141 (48%), Positives = 94/141 (66%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 +G G+DVH + +I+GGV +P+++GLL HSD DV +HA+ DALLGAA GDIG+ FP Sbjct: 232 VGFGYDVHRLVDDRKLILGGVEVPHDRGLLGHSDADVLVHAVMDALLGAAGAGDIGRWFP 291 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 D DP ++G S +LL ++ +G N+D ++A+AP++ P I +MR +A LG Sbjct: 292 DDDPTYRGISSMDLLVRVAAFLRERGLETSNLDAVVVAEAPRLSPFISRMRDNLASVLGV 351 Query: 123 HMDDVNVKATTTEKLGFTGRG 143 VNVKATTTE LGFTG G Sbjct: 352 SPAAVNVKATTTEGLGFTGSG 372 >UniRef50_Q2GER2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Neorickettsia RepID=ISPF_NEOSM Length = 168 Score = 219 bits (558), Expect = 3e-56, Method: Composition-based stats. Identities = 75/165 (45%), Positives = 99/165 (60%), Gaps = 8/165 (4%) Query: 2 RIGHGFDVHAF-----GGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAA---A 53 R+G G+DVH G I++ GV +P E ++AHSDGDVALHAL DALLGAA Sbjct: 3 RVGFGYDVHKIDKPVKTGNTCIVLCGVSVPCEYKVIAHSDGDVALHALVDALLGAACIEG 62 Query: 54 LGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMR 113 DIG LFPDTD ++G S + IQ GY + N D+TI+ + P++ + +M+ Sbjct: 63 ANDIGMLFPDTDEKWRGKSSSYFVEHVVTLIQRAGYVVNNADLTIVCETPRIQQYKSEMQ 122 Query: 114 VFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 +A+ L + +NVKATTTEKLGF GR EGIA A+ L K Sbjct: 123 QQVADLLCVRKEQINVKATTTEKLGFEGRKEGIAAYAIVSLTKIR 167 >UniRef50_Q9ZM19 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=14 Tax=Helicobacter RepID=ISPDF_HELPJ Length = 409 Score = 218 bits (557), Expect = 4e-56, Method: Composition-based stats. Identities = 68/157 (43%), Positives = 98/157 (62%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 IG GFD HAF + P+++GGV + E GL AHSDGD LHA+ DA+LGA GDIG+ FP Sbjct: 252 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 311 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 D DP +K A S+ELL+ Q+ G+ L + TI ++ PK+ P+ P + +++ LG Sbjct: 312 DNDPKYKNASSKELLKIVLDFSQSIGFELLEMGATIFSEIPKITPYKPAILENLSQLLGL 371 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 +++KATT EK+GF G+ EG+ +A + K Sbjct: 372 EKSQISLKATTMEKMGFIGKQEGLLVQAHVSMRYKQK 408 >UniRef50_D1CCF0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CCF0_THET1 Length = 159 Score = 217 bits (553), Expect = 1e-55, Method: Composition-based stats. Identities = 75/157 (47%), Positives = 99/157 (63%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MR G GFD H F ++IGGV IP+ GL HSD DV HA+ DALLGAA++GDIG L Sbjct: 1 MRSGIGFDAHRFVVGRKLVIGGVAIPHHMGLEGHSDADVLTHAIIDALLGAASMGDIGTL 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 F DP G DS +LL + ++ G+ + +VD TIIAQAP+M P+I MR I++ + Sbjct: 61 FSSDDPDLAGVDSTKLLAKVCEYVRGAGWDIDHVDSTIIAQAPRMSPYIGAMRDKISKVM 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 + V++KATTT+ LG GR EGIA AV + + Sbjct: 121 EIPLTSVSIKATTTDGLGPWGREEGIAALAVCNISRK 157 >UniRef50_Q4FM31 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Candidatus Pelagibacter RepID=ISPDF_PELUB Length = 371 Score = 216 bits (552), Expect = 2e-55, Method: Composition-based stats. Identities = 68/156 (43%), Positives = 94/156 (60%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 ++ G GFDVH + +GGV+IP G L HSDGD LHA+TDA+LGA ++GDIG+ Sbjct: 214 IKFGIGFDVHRLVPNKKLYLGGVKIPSPIGTLGHSDGDPVLHAVTDAILGACSMGDIGEK 273 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 F D + FK S LL E ++ KGY + N+D+ II Q PK+ + Q+ IA+ Sbjct: 274 FSDKNKKFKNIRSTILLSEIIKQTLKKGYLINNLDINIITQKPKIQKYKKQILNCIAKIC 333 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 +N+K TTEKLG G+ + IACE +A +IK Sbjct: 334 NISPTQINIKGKTTEKLGVIGKEKAIACEVIASVIK 369 >UniRef50_A3ZYT9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A3ZYT9_9PLAN Length = 162 Score = 216 bits (551), Expect = 2e-55, Method: Composition-based stats. Identities = 68/157 (43%), Positives = 95/157 (60%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIG G D H GP+ +GGV I +++ L+ HSD DV +HA+TDALLGAA L DIG+ Sbjct: 2 IRIGLGHDTHRLAEGGPLRLGGVDILHDQHLVGHSDADVLMHAITDALLGAANLPDIGEW 61 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP++ +G DS + LR A+ ++ +G+ + N+D I AQ PK+ P+ MR +A L Sbjct: 62 FPNSAAENRGRDSADFLRFAYHKVNEEGWRIINIDTVIFAQEPKLSPYKEAMRTALANIL 121 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 V +KA T E++G GR E I E V LL K Sbjct: 122 TIEPAQVGIKAKTGEQVGLVGRREAIQAECVVLLEKI 158 >UniRef50_Q5P993 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=7 Tax=Anaplasmataceae RepID=ISPF_ANAMM Length = 184 Score = 216 bits (550), Expect = 3e-55, Method: Composition-based stats. Identities = 78/162 (48%), Positives = 105/162 (64%), Gaps = 4/162 (2%) Query: 1 MRIGHGFDVHAFGGEGP----IIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGD 56 R+G G+DVH F P I++ GV I + + + AHSDGDV HAL DALLG G Sbjct: 10 FRVGIGYDVHGFADSPPENGHIVLCGVEIAFHRKIKAHSDGDVGTHALVDALLGCVGEGS 69 Query: 57 IGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFI 116 IG+ FP+TDP ++ S L EA + AKGY + N D+TI+ + PK++PH+P+M++F+ Sbjct: 70 IGEHFPNTDPRWENMSSTHFLLEAQSKALAKGYAVLNFDLTIVCELPKIIPHVPKMKLFM 129 Query: 117 AEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 ++ LG +N+KA TTEKLGF GRGEGIA AV L K T Sbjct: 130 SKLLGMDASAINIKAVTTEKLGFIGRGEGIAAHAVVLCRKVT 171 >UniRef50_C3XI64 Bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Helicobacter bilis ATCC 43879 RepID=C3XI64_9HELI Length = 485 Score = 215 bits (549), Expect = 3e-55, Method: Composition-based stats. Identities = 70/157 (44%), Positives = 98/157 (62%), Gaps = 1/157 (0%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 IG+G D+H F + + GV+I G AHSDGDVA+HA+ D++LGA GDIG+LFP Sbjct: 328 IGYGSDIHGFIDSKDMYLCGVKIESSMGFKAHSDGDVAIHAIIDSILGAMNYGDIGELFP 387 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 D+ FK DS+ LL+E + + G L N+D+TI AQ P++ P+ QM+ +A L Sbjct: 388 DSKDEFKNIDSKILLKEVYDYCLSVGLELINLDITITAQTPRISPYKAQMQEVLANILYL 447 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 V++KA+T E LGF GR EG+ ++A L KA K Sbjct: 448 PKMCVSIKASTAEGLGFVGRKEGVLVNSIAQL-KARK 483 >UniRef50_B8D9J7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=55 Tax=Gammaproteobacteria RepID=ISPF_BUCA5 Length = 161 Score = 215 bits (549), Expect = 4e-55, Method: Composition-based stats. Identities = 84/159 (52%), Positives = 117/159 (73%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIG+GFD+HAFG P+IIGGV IP EKGL+AHS+GD+ +H+L DALLGA A+GDIG Sbjct: 1 MRIGYGFDLHAFGSTKPLIIGGVLIPCEKGLIAHSNGDLLIHSLIDALLGATAMGDIGSF 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP + +K DSR LL++ W +I Y + N+D+TIIA+ PKMLP+I MR ++ DL Sbjct: 61 FPSNNYIYKNIDSRILLKKIWNKIILLNYDICNIDITIIAEYPKMLPYIFFMRSNLSLDL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 +D++++K+TT++K+G GR E IAC ++ +LIK K Sbjct: 121 NTEIDNISIKSTTSKKIGCIGRKEAIACHSIVMLIKNKK 159 >UniRef50_C6BS25 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase n=2 Tax=Desulfovibrio RepID=C6BS25_DESAD Length = 396 Score = 215 bits (548), Expect = 5e-55, Method: Composition-based stats. Identities = 70/155 (45%), Positives = 95/155 (61%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 +G G+DVH FG P+++GGV IP ++AHSDGDV LHAL DA+LG GDIG FP Sbjct: 241 VGWGYDVHKFGEGRPMVLGGVPIPGGPEVIAHSDGDVLLHALADAILGLFGGGDIGHHFP 300 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 DT A + S +++E + + G + +VD+T+I+Q PK+ PH +R +A +G Sbjct: 301 DTSDACENMSSGIIVKEVMAKAEEAGVEIVHVDLTVISQIPKLSPHRELIRKNVASVMGL 360 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 VNVKATT EKLGFTG +GI A +K Sbjct: 361 DKAQVNVKATTEEKLGFTGEKKGIKAVAAVTGLKK 395 >UniRef50_Q310X3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Desulfovibrionales RepID=ISPDF_DESDG Length = 399 Score = 214 bits (547), Expect = 5e-55, Method: Composition-based stats. Identities = 73/155 (47%), Positives = 94/155 (60%), Gaps = 1/155 (0%) Query: 3 IGHGFDVHAFG-GEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 +G G+DVH FG P+ +GGV I G++AHSDGDV LHALTDA+LG LGDIG LF Sbjct: 241 VGWGYDVHRFGSDGRPMKLGGVPIAGGPGVIAHSDGDVLLHALTDAVLGCMGLGDIGMLF 300 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 PDTD A+ ADS +L E + + G + +VD+TII Q P++ P Q+ I Sbjct: 301 PDTDAAYDNADSAVMLNEVLEKARNAGLLITHVDLTIITQIPRITPWRDQIHKNICRITR 360 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 VN+KATT EKLGFTG +GI A ++ Sbjct: 361 LDASSVNLKATTEEKLGFTGEKKGIKAVAAVTALR 395 >UniRef50_D1B5E2 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B5E2_THEAS Length = 381 Score = 212 bits (541), Expect = 3e-54, Method: Composition-based stats. Identities = 75/157 (47%), Positives = 97/157 (61%), Gaps = 2/157 (1%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPY-EKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 R GHG+DVH P+I+GG+ I GL HSD D HA+ DA+LGAA DIG L Sbjct: 226 RCGHGYDVHPLVPGRPLILGGLEIEGANLGLQGHSDADAVCHAVADAILGAAGEPDIGTL 285 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +D +KGA S +LL EA+RR+ G+ + VDVTI AQ PK+ IP++R I+ L Sbjct: 286 FPASDDRYKGAYSLDLLAEAYRRVVQGGFQIQWVDVTINAQVPKLSSWIPRIRSSISRAL 345 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 G + VNVK + E +G GRGE I C AVA L ++ Sbjct: 346 G-GLKVVNVKVKSGEHVGSVGRGESIVCHAVATLRRS 381 >UniRef50_B0SAT2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=6 Tax=Leptospira RepID=ISPF_LEPBA Length = 162 Score = 212 bits (540), Expect = 3e-54, Method: Composition-based stats. Identities = 62/161 (38%), Positives = 88/161 (54%), Gaps = 2/161 (1%) Query: 1 MRIGHGFDVHAF--GGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIG 58 R+G+G D H P+++ GV I E L HSD DV LHA+ DA+LGA +LGDIG Sbjct: 2 FRVGNGIDFHKLIHEPFRPLVLAGVEIKSEFAFLGHSDADVILHAVADAILGALSLGDIG 61 Query: 59 KLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAE 118 FPDTDP +K S ++ + + K + L NVD T + PK+ P ++ +A Sbjct: 62 VHFPDTDPQYKNMKSTRIIEKCLELVAEKKFKLINVDCTYVGDHPKISPIRAELNASLAN 121 Query: 119 DLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 +D V++KATT+E +G GR EG+ A L+ K Sbjct: 122 ITKLPLDCVSIKATTSEGMGALGRSEGVMVMATVLIESLKK 162 >UniRef50_A5V2U9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=8 Tax=Bacteria RepID=ISPDF_SPHWW Length = 382 Score = 211 bits (537), Expect = 1e-53, Method: Composition-based stats. Identities = 82/154 (53%), Positives = 99/154 (64%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 R GFDVH F + +GGVRI +++ L HSD DVALHALTDALLG A GDIG F Sbjct: 225 RTAMGFDVHGFTAGDGVQLGGVRIAHDRALAGHSDADVALHALTDALLGTIAAGDIGSHF 284 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 P +D +KGADS L A + A G + VD+TII +APK+ PH +R IA LG Sbjct: 285 PPSDQRWKGADSAMFLAHARDLVAAAGGIVDFVDLTIICEAPKVGPHRAAIRDRIAALLG 344 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 V+VKATTTE+LGFTGR EGIA +AVA + Sbjct: 345 LTAGQVSVKATTTERLGFTGRREGIAAQAVATVR 378 >UniRef50_B2URI3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Verrucomicrobia RepID=ISPF_AKKM8 Length = 169 Score = 210 bits (536), Expect = 1e-53, Method: Composition-based stats. Identities = 68/154 (44%), Positives = 97/154 (62%), Gaps = 1/154 (0%) Query: 3 IGHGFDVHAFGG-EGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 G G+D+H F P+++GGV IP +GL HSD DV HA+ DALLGAA L DIG F Sbjct: 8 TGIGYDIHRFAEVPRPLMLGGVHIPSSRGLDGHSDADVLCHAIADALLGAAGLPDIGYWF 67 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 P DP+ K S +++ +A I+ +G + NVD ++IA++P++ P++ QM+ + LG Sbjct: 68 PPGDPSCKDIPSLDIVAKAVSLIRERGGRIVNVDSSLIAESPRISPYLEQMKGALGAALG 127 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 V +KATT E+LG GR EGIA AVA ++ Sbjct: 128 ISPVRVGIKATTNEQLGALGRREGIAAFAVAAIL 161 >UniRef50_A7HDA2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=5 Tax=Bacteria RepID=ISPDF_ANADF Length = 386 Score = 208 bits (531), Expect = 4e-53, Method: Composition-based stats. Identities = 79/155 (50%), Positives = 101/155 (65%), Gaps = 1/155 (0%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G G+D H F +++GGV + GLL HSD DV HA+ DA+LG A LGD+G+ FPD Sbjct: 233 GVGYDTHRFAEGRRLVLGGVEFEGD-GLLGHSDADVCAHAIGDAILGGAGLGDLGRHFPD 291 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCH 123 TDP +KG S LLRE ++ A G+ +GN DVT+ A+ PK+ P +MR +AE LG Sbjct: 292 TDPRWKGVSSLALLREIAAKVAAAGFRVGNCDVTLAARRPKIAPRAEEMRARLAEALGVT 351 Query: 124 MDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 VNVKATT E +GF GRGEGIA AVALL++ Sbjct: 352 PGQVNVKATTGEGMGFVGRGEGIAAHAVALLVRVR 386 >UniRef50_B9KAZ0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Thermotoga RepID=ISPF_THENN Length = 165 Score = 207 bits (529), Expect = 7e-53, Method: Composition-based stats. Identities = 61/158 (38%), Positives = 89/158 (56%), Gaps = 3/158 (1%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 M IG G+D H +++ GV I G L HSDGDV HA+ DALLGA LGDIG Sbjct: 6 MFIGFGYDRHPLVEGRRLVLAGVEIDAPLGSLGHSDGDVLSHAIIDALLGAGCLGDIGTW 65 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP+T +K A+S +LL+E + ++ +G+++ NVD T++A K+ P+ ++ + L Sbjct: 66 FPET-KEYKDANSLDLLKETVKILEERGFSVVNVDATVVASIVKLSPYREKILENLKSAL 124 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 VNVK + LGF G GI+ AV L+ + Sbjct: 125 ET--SRVNVKFKSGNTLGFEGEERGISAYAVCLVEEKK 160 >UniRef50_B8CD73 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Thalassiosira pseudonana RepID=B8CD73_THAPS Length = 263 Score = 207 bits (527), Expect = 1e-52, Method: Composition-based stats. Identities = 69/183 (37%), Positives = 97/183 (53%), Gaps = 26/183 (14%) Query: 1 MRIGHGFDVHAFGG----EGPIIIGGVRIPYE----------------------KGLLAH 34 +RIGHGFD+H P++IGGV I +E G++AH Sbjct: 74 LRIGHGFDIHRMVPLEEAGQPVVIGGVVIDHEDQKWTDKEGTYTGTPNSIYKTQLGVIAH 133 Query: 35 SDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNV 94 SDGDV H+L DA+ GA L DIG++F DTDP +KG DS + + A+ ++ GY +GNV Sbjct: 134 SDGDVIYHSLVDAIFGALTLPDIGQVFQDTDPRWKGCDSSKFMEHAYEVMKYYGYQIGNV 193 Query: 95 DVTIIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 DVT+I + PK+ P+M+ I L VN+KA T E++ G ++C V L Sbjct: 194 DVTLILERPKVAGFKPRMKENIVRLLHTTDGRVNIKARTHERVDSVGELRSLSCHVVVTL 253 Query: 155 IKA 157 K Sbjct: 254 EKV 256 >UniRef50_Q2RFM1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=4 Tax=Bacteria RepID=ISPF_MOOTA Length = 163 Score = 206 bits (525), Expect = 2e-52, Method: Composition-based stats. Identities = 91/155 (58%), Positives = 110/155 (70%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIG+G+DVH +++GGV IPY++GL HSD DV LHAL DALLGAAALGDIG Sbjct: 1 MRIGYGYDVHGLVPGRKLVLGGVTIPYDRGLAGHSDADVLLHALADALLGAAALGDIGHY 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP DP +K ADS LLRE +R +Q GY L N D TI AQ P++ P+I MR IA L Sbjct: 61 FPPGDPRYKDADSMLLLREVYRHVQTAGYRLANADATITAQEPRLAPYIDAMRERIAAAL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 G + ++VKATTTE LGFTGRGEGI+ +AV LL+ Sbjct: 121 GVTKEQISVKATTTEGLGFTGRGEGISAQAVVLLL 155 >UniRef50_Q1MR76 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=4 Tax=Desulfovibrionaceae RepID=ISPDF_LAWIP Length = 399 Score = 205 bits (524), Expect = 3e-52, Method: Composition-based stats. Identities = 62/163 (38%), Positives = 92/163 (56%), Gaps = 7/163 (4%) Query: 3 IGHGFDVHAFGGE-------GPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALG 55 +G+G+DVH + E + +GG+ IP ++AHSDGDV LHAL DALLG G Sbjct: 237 VGYGYDVHKYVTEDQINQPIRSMRLGGISIPNAPNVVAHSDGDVLLHALMDALLGCIGGG 296 Query: 56 DIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVF 115 DIG FPD+D + G +S LL ++ + ++D TI+AQ PK+ + +R Sbjct: 297 DIGLHFPDSDKRYDGINSAILLDHVLTKVLESSIKIVHMDATIVAQLPKISQYREAIRSN 356 Query: 116 IAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 ++ L + +VN+KATT E LGFTG +GI + I+ + Sbjct: 357 LSRLLDLDLANVNIKATTEEGLGFTGECKGIKAIVIVTAIRIS 399 >UniRef50_C1F762 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F762_ACIC5 Length = 207 Score = 205 bits (523), Expect = 4e-52, Method: Composition-based stats. Identities = 72/159 (45%), Positives = 94/159 (59%), Gaps = 3/159 (1%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIG+G+D HAF P+ IGG+ I + +GL HSDGDV LHA+TDALLGA A GDIG Sbjct: 3 IRIGYGWDSHAFKPGVPLRIGGLAIEHPEGLAGHSDGDVLLHAITDALLGAVAAGDIGSF 62 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP DP +KGADS L A IQ GY + NVD T++ AP++ P +MR +A L Sbjct: 63 FPPGDPRWKGADSAIFLNIALEEIQNAGYRIANVDTTLVLAAPRIGPIAGEMRERVASLL 122 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 + D+++KA T E LG A LL + + Sbjct: 123 DIPLGDISIKAKTPEGLGL---DHVAQAHATVLLERVEE 158 >UniRef50_Q73KC6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Bacteria RepID=ISPF_TREDE Length = 161 Score = 205 bits (523), Expect = 4e-52, Method: Composition-based stats. Identities = 70/155 (45%), Positives = 97/155 (62%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MR G G+D+H +++GGV IP++KG AHSDGDV LHA+TDALLGA +GDIG+ Sbjct: 1 MRTGLGYDLHRLVRGKKLMMGGVHIPFKKGEKAHSDGDVLLHAITDALLGACGMGDIGEF 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +D +K A+S ELL W RI G+ + N+D II + PK+LP ++R IA L Sbjct: 61 FPPSDKKWKDANSSELLSTVWERISEAGWKIQNIDCVIIIEEPKILPFREEIRKSIAGIL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 + + +KA T E +G GRG+ +A A L+ Sbjct: 121 KIEKEQIFIKAKTGEGIGIIGRGKAVAALASCLIF 155 >UniRef50_Q1IVA8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Candidatus Koribacter versatilis Ellin345 RepID=ISPF_ACIBL Length = 155 Score = 201 bits (513), Expect = 5e-51, Method: Composition-based stats. Identities = 72/156 (46%), Positives = 93/156 (59%), Gaps = 3/156 (1%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R+G GFD H F P+ IGG+ IP+ GL HSDGDV LHA+TDALLGA A GDIG Sbjct: 2 IRVGLGFDSHEFREGIPLRIGGLTIPHTHGLSGHSDGDVLLHAITDALLGAVAAGDIGAF 61 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA+S + EA R I+ GY +GNVD +++ APK+ PH ++ +A+ L Sbjct: 62 FPPSDPKWKGANSVVFIEEAMRHIETAGYRVGNVDCSLVLNAPKIGPHAKAIQESVAKLL 121 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 V +KA T E L G V LL K Sbjct: 122 KIEPTAVGIKAKTPEGLNLDG---TALAHVVVLLEK 154 >UniRef50_B2KDX1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase n=1 Tax=Elusimicrobium minutum Pei191 RepID=B2KDX1_ELUMP Length = 382 Score = 200 bits (510), Expect = 1e-50, Method: Composition-based stats. Identities = 56/154 (36%), Positives = 84/154 (54%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 R G GFD+H + IGG+ IP+ KG L HSDGDV LHA+ DA LGA G+IG + Sbjct: 226 RTGIGFDLHRLVEGRKLFIGGLEIPHTKGFLGHSDGDVVLHAVCDAALGAVCAGEIGVYY 285 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 P TD +G S ++ ++ ++ K + ++D II + PKM PH +R + + Sbjct: 286 PPTDAKIEGISSVDIAKKVIEILKEKNARIVHIDAVIITEEPKMKPHYQAIRESLGKVFN 345 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 +D ++ K+ + EKLG G G C+ V + Sbjct: 346 MGVDSISFKSKSHEKLGDIGAGNAAMCQCVVTVK 379 >UniRef50_B7FYU1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B7FYU1_PHATR Length = 244 Score = 199 bits (508), Expect = 2e-50, Method: Composition-based stats. Identities = 66/180 (36%), Positives = 93/180 (51%), Gaps = 25/180 (13%) Query: 1 MRIGHGFDVHAFGG----EGPIIIGGVRIPY---------------------EKGLLAHS 35 +RIGHGFD+H P++IGGV I + E G++AHS Sbjct: 62 LRIGHGFDIHRMAPLAEAGQPVVIGGVVIDHLPQKWTDAEGRYVEKGGVYETELGVVAHS 121 Query: 36 DGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVD 95 DGDV H++ DA+ GA L DIG++F DTDP +KG DS + + A + GY +GN+D Sbjct: 122 DGDVIYHSIVDAIFGALTLPDIGQVFQDTDPRWKGCDSSKFMEHAHTVMADYGYKVGNID 181 Query: 96 VTIIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 VT+I + PK+ P M+ I L VN+KA T E++ G ++C V L Sbjct: 182 VTLILERPKVASFKPAMKKNIVNLLQTTPGRVNIKARTHERVDSVGELRSLSCHVVMTLE 241 >UniRef50_B1L8F8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=4 Tax=Thermotogaceae RepID=B1L8F8_THESQ Length = 160 Score = 199 bits (506), Expect = 3e-50, Method: Composition-based stats. Identities = 63/157 (40%), Positives = 86/157 (54%), Gaps = 3/157 (1%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 M IG G+D H +I+ GV I G L HSDGDV HA+ DALLGA LGDIG Sbjct: 1 MFIGFGYDRHPLVEGRRLILAGVEIDSPVGSLGHSDGDVLSHAIIDALLGAVGLGDIGTW 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP+T ++GA S ELL++ I+ +G+ + NVD T++ +M + ++ + L Sbjct: 61 FPET-EEYRGAISLELLKKTMGMIEERGFKVINVDSTVVLSGVRMSAYRDRIVENLKSVL 119 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 VNVK + LGF G G GI+ AV LL + Sbjct: 120 KTP--HVNVKFKSGNTLGFEGEGRGISAYAVCLLEEK 154 >UniRef50_A8F4L5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Thermotoga lettingae TMO RepID=A8F4L5_THELT Length = 163 Score = 198 bits (505), Expect = 4e-50, Method: Composition-based stats. Identities = 52/155 (33%), Positives = 83/155 (53%), Gaps = 2/155 (1%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R+G G D H F +I+ GV I GLL HSDGD H+L D+LLGA LGDIG+ Sbjct: 4 LRVGIGTDRHPFVEGRKLILAGVEINSSVGLLGHSDGDALCHSLIDSLLGAVCLGDIGQY 63 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP+TD +K A S LL + I+ +G+ + N+D + ++ + M +++ + Sbjct: 64 FPETD-EWKDASSIFLLEKIIDMIRDQGWEVVNIDTIVTCGRIRLSDYRDDMIKNLSKIM 122 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 ++VK + LGF + +G++ + LL Sbjct: 123 NIPEQRISVKFKSANGLGFESQ-DGVSVLTICLLR 156 >UniRef50_B1Q2Q5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Perkinsus marinus RepID=B1Q2Q5_9ALVE Length = 237 Score = 198 bits (504), Expect = 5e-50, Method: Composition-based stats. Identities = 65/162 (40%), Positives = 100/162 (61%), Gaps = 6/162 (3%) Query: 1 MRIGHGFDVHAF----GGEGPIIIGGVRIP--YEKGLLAHSDGDVALHALTDALLGAAAL 54 +RIGH +D+H F GP I+ GV +P + GL+AHSDGDV H++TDA+LG+ L Sbjct: 74 LRIGHAWDIHRFGRRSAENGPFILAGVEVPDCSDIGLVAHSDGDVIFHSVTDAILGSIGL 133 Query: 55 GDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRV 114 DIG+ +PDTDP ++G S + L + +R A G+ + ++DVT++ + PK+ +P + Sbjct: 134 RDIGQYYPDTDPEWEGQSSDKFLHDTLKRASALGFRVISIDVTLVLERPKVGKVMPAVVE 193 Query: 115 FIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 + + + + VNVKA T+EKL G G+ + AV LL K Sbjct: 194 NLRKAINDNRASVNVKARTSEKLNAAGEGKSVEAHAVVLLYK 235 >UniRef50_C4RE02 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (Fragment) n=1 Tax=Micromonospora sp. ATCC 39149 RepID=C4RE02_9ACTO Length = 220 Score = 197 bits (503), Expect = 8e-50, Method: Composition-based stats. Identities = 67/153 (43%), Positives = 89/153 (58%), Gaps = 3/153 (1%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 R+ G DVHAF P + G+ P + GL HSD DV HA +ALL AA LGD+G F Sbjct: 65 RVAIGTDVHAFEVGRPCWLAGLLWPGQDGLAGHSDADVVAHAACNALLSAAGLGDLGSNF 124 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 +P + GA LL E RR++A G+ +GNV V ++ PK+ P + ++E +G Sbjct: 125 GVAEPEWAGAPGVALLAETARRVRAAGFEIGNVSVQVVGNRPKIGPRRAEAEAVLSEAVG 184 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 V V A TT+ LGFTGRGEG+A AVAL+ Sbjct: 185 AP---VAVSAATTDGLGFTGRGEGLAGIAVALV 214 >UniRef50_C4XSW4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=7 Tax=Desulfovibrionales RepID=ISPDF_DESMR Length = 400 Score = 197 bits (502), Expect = 9e-50, Method: Composition-based stats. Identities = 75/162 (46%), Positives = 99/162 (61%), Gaps = 8/162 (4%) Query: 3 IGHGFDVHAFG--------GEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAAL 54 G+G+DVH + P+ +GG I +LAHSDGDV LHALTDA+LG A Sbjct: 237 TGYGYDVHRYADPRNPGKQPPRPMKLGGFPILGAPEVLAHSDGDVLLHALTDAVLGCVAG 296 Query: 55 GDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRV 114 GDIG+LFPD++P F S L EA +AKG T+ +VD+TIIAQ PK+ PH +R+ Sbjct: 297 GDIGRLFPDSNPDFDNMASGVFLSEALLAAKAKGLTITHVDLTIIAQIPKISPHAEAIRL 356 Query: 115 FIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 +A LG + + VN+KATT E LGFTG +GI A+ + Sbjct: 357 NVAALLGLNKEQVNLKATTEEGLGFTGEKKGIKAVALVSGWR 398 >UniRef50_Q4MZY9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Theileria RepID=Q4MZY9_THEPA Length = 210 Score = 197 bits (501), Expect = 1e-49, Method: Composition-based stats. Identities = 72/159 (45%), Positives = 97/159 (61%), Gaps = 6/159 (3%) Query: 2 RIGHGFDVHAF----GGEGPIIIGGVRIPYE-KGLLAHSDGDVALHALTDALLGAAALGD 56 R+G G+D+H G +I+GGV +P + +LAHSDGDV LH+++DA+LGA GD Sbjct: 51 RVGFGYDIHRVVNAGEGGKTLILGGVEVPGDSVRVLAHSDGDVVLHSISDAVLGALGKGD 110 Query: 57 IGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFI 116 IG FPDT+P F+ +S ++LR + GY+L NVD II + PK+ P Q++ + Sbjct: 111 IGDYFPDTNPQFEDYNSVKILRRVLEIAEEMGYSLVNVDACIILEYPKLGPVKSQIKENL 170 Query: 117 AEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 LG H VNVKA T EKL G+G IAC AV LL Sbjct: 171 QSLLG-HGTVVNVKAKTNEKLDSIGKGSAIACHAVVLLQ 208 >UniRef50_C8R0Y1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase n=1 Tax=Desulfurivibrio alkaliphilus AHT2 RepID=C8R0Y1_9DELT Length = 454 Score = 191 bits (486), Expect = 7e-48, Method: Composition-based stats. Identities = 60/133 (45%), Positives = 83/133 (62%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 RIGHG+DVH + P+I+GGV I + GLL HSD DV HAL DA+LGA GDIG+ F Sbjct: 235 RIGHGYDVHRLVTDRPLILGGVTIEHHLGLLGHSDADVLTHALCDAILGALGAGDIGRHF 294 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 PD D ++G S +LL + ++ A L + D+TIIA+ PK+ P + M+ +A Sbjct: 295 PDNDQQYRGISSLKLLAQVMTKVWAANCRLHHADLTIIAEKPKLAPQLAAMQANLAAACQ 354 Query: 122 CHMDDVNVKATTT 134 + +N+KATTT Sbjct: 355 VNPSQINLKATTT 367 >UniRef50_D0RP30 Bifunctional enzyme IspD/ispF n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RP30_9RICK Length = 400 Score = 190 bits (485), Expect = 9e-48, Method: Composition-based stats. Identities = 57/154 (37%), Positives = 94/154 (61%), Gaps = 1/154 (0%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G G+D+H + IGG++IP + G + HSDGD LHAL D+ +GAA LGDIG LFP Sbjct: 248 GIGYDIHKMSPGYNLYIGGIKIPSKYGAVGHSDGDSLLHALIDSFMGAARLGDIGTLFP- 306 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCH 123 + +KG S +L+RE +++ + ++D+ II Q+P + + +++ I++ Sbjct: 307 NNKKYKGIRSTKLVREIIIKLKMINLKISSIDLNIILQSPNLKNYKEKIKKNISKLCFIK 366 Query: 124 MDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 + +N+KA TT+KLG G+ + +ACE ++ L A Sbjct: 367 PNKINIKAKTTDKLGIIGKNKALACEVISTLENA 400 >UniRef50_Q72HP8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=5 Tax=Deinococci RepID=ISPF_THET2 Length = 152 Score = 189 bits (480), Expect = 4e-47, Method: Composition-based stats. Identities = 66/154 (42%), Positives = 85/154 (55%), Gaps = 4/154 (2%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIG+G D H P+ + G+ IP G LAHSDGD ALHALTDALL A LGDIG L Sbjct: 1 MRIGYGEDSHRLEEGRPLYLCGLLIPSPVGALAHSDGDAALHALTDALLSAYGLGDIGLL 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTDP ++G S LREA R ++A+G L + + PK+ PH + +A L Sbjct: 61 FPDTDPRWRGERSEVFLREALRLVEARGARLLQASLVLTLDRPKLGPHRKALVDSLARLL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 D + + T+E L + + AV LL Sbjct: 121 RLPQDRIGLTFKTSEGLAPS----HVQARAVVLL 150 >UniRef50_B3L0R0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=4 Tax=Plasmodium RepID=B3L0R0_PLAKH Length = 272 Score = 186 bits (474), Expect = 2e-46, Method: Composition-based stats. Identities = 64/177 (36%), Positives = 89/177 (50%), Gaps = 19/177 (10%) Query: 1 MRIGHGFDVHAFGGEGP------------------IIIGGVRIPYEKGLLAHSDGDVALH 42 +RIG G+D+H P + IGGV++ +L+HSDGDV H Sbjct: 94 VRIGQGYDIHQIRVSTPEDITVDSSADANKQNFKRLTIGGVQVD-TISVLSHSDGDVIYH 152 Query: 43 ALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQA 102 AL DALLG D+G LFPD +K S LR A + K Y + N+D+ +IA+ Sbjct: 153 ALVDALLGGMNCLDLGTLFPDGSEKYKNKKSISFLRYARLLLYKKNYAIANLDIIVIAEI 212 Query: 103 PKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 PK+ P ++ I+ LG V++K T EKLG G+ + I C A ALLI+ Sbjct: 213 PKISPIREEIVRNISSALGISESQVSLKGKTHEKLGPIGQKKAIECFANALLIRKKS 269 >UniRef50_Q1QBM3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=16 Tax=Bacteria RepID=ISPF_PSYCK Length = 168 Score = 186 bits (474), Expect = 2e-46, Method: Composition-based stats. Identities = 89/159 (55%), Positives = 109/159 (68%), Gaps = 4/159 (2%) Query: 1 MRIGHGFDVHAFGGEGP----IIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGD 56 ++IG G DVHAF G +++ GV I + LLAHSDGDV LHAL DALLGA ALGD Sbjct: 4 IKIGQGIDVHAFHNNGQQQQYVVLAGVPIDHTHSLLAHSDGDVVLHALADALLGALALGD 63 Query: 57 IGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFI 116 IG+ FPDTD A G DSR LLR + ++ A GY LGN D+T++ + PK+ PH MR I Sbjct: 64 IGQHFPDTDAANAGLDSRVLLRYVYGKVLAAGYILGNADITVMCERPKLAPHNLAMRANI 123 Query: 117 AEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 A DL + +++VKATTTEKLGFTGR EGI AV LL+ Sbjct: 124 ASDLQTDVSNISVKATTTEKLGFTGRQEGIMANAVVLLV 162 >UniRef50_B4U9N6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Aquificaceae RepID=ISPF_HYDS0 Length = 156 Score = 186 bits (474), Expect = 2e-46, Method: Composition-based stats. Identities = 54/155 (34%), Positives = 78/155 (50%), Gaps = 3/155 (1%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 RIG G D H F + +GG GL HSDGD LHA+TDA+LGA A DIG LF Sbjct: 3 RIGIGQDAHYFEKGKKLYLGGEEFDIGYGLKGHSDGDALLHAITDAILGALAKTDIGTLF 62 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 PD K +S + L +A + Y++ N+D IIA P + ++ ++ L Sbjct: 63 PDKSKENKNRNSVDFLNKALEIMYDMDYSIVNLDCNIIADKPNISSVRDKIIESLSRLLS 122 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 D++++KA T E + + + +ALL K Sbjct: 123 IPKDNISIKAKTKEGYN---KEDSLEVVCIALLQK 154 >UniRef50_A5CTY4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=28 Tax=Actinobacteria (class) RepID=ISPDF_CLAM3 Length = 410 Score = 185 bits (471), Expect = 4e-46, Method: Composition-based stats. Identities = 64/156 (41%), Positives = 87/156 (55%), Gaps = 3/156 (1%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G G DVHA P+ + G+ P E GL HSDGD HA+ DALL AA LGDIG + Sbjct: 257 LRSGIGTDVHAVDASQPLWLAGLHWPGEAGLAGHSDGDAVSHAMCDALLSAAGLGDIGGI 316 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 F DP GA LR ++ GY + NV V ++A PK+ P + ++ + Sbjct: 317 FGTDDPELDGAHGEVFLRRTAELVRDAGYRIVNVAVQVMAVRPKLSPRRAEAERILSAAV 376 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 G V++ TTT+ LGFTGRG+G+A A AL+ + Sbjct: 377 GAP---VSLAGTTTDGLGFTGRGDGVAAVATALVER 409 >UniRef50_B6KAQ3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Toxoplasma gondii RepID=B6KAQ3_TOXGO Length = 338 Score = 184 bits (467), Expect = 1e-45, Method: Composition-based stats. Identities = 60/138 (43%), Positives = 84/138 (60%), Gaps = 3/138 (2%) Query: 25 IPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRI 84 + G++AHSDGDV LHA+ DA+ GA ALGDIG+ F D++PAF+G S L+ A + Sbjct: 176 VENSFGVVAHSDGDVLLHAVCDAVFGAFALGDIGEHFSDSNPAFRGMSSSLLVARALEIV 235 Query: 85 QAK--GYTLGNVDVTIIAQAPKML-PHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTG 141 +AK + LG+VD T++ A K +MR +AE L V+VKA T+E +G G Sbjct: 236 RAKHPDWRLGSVDATVVFDAMKFGRARKQKMRENLAELLQLPAAAVSVKAKTSEGVGPVG 295 Query: 142 RGEGIACEAVALLIKATK 159 R E +AC V L K+T+ Sbjct: 296 RKEAVACHVVLTLFKSTR 313 Score = 42.3 bits (99), Expect = 0.005, Method: Composition-based stats. Identities = 18/37 (48%), Positives = 22/37 (59%), Gaps = 7/37 (18%) Query: 1 MRIGHGFDVHA-----FGGEGPIIIGGVRI--PYEKG 30 RIGHG+D+H GP++IGGV I P EKG Sbjct: 36 FRIGHGYDLHRVTANPLEATGPLVIGGVCISTPPEKG 72 >UniRef50_P62368 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Plasmodium RepID=ISPF_PLAF7 Length = 240 Score = 183 bits (466), Expect = 1e-45, Method: Composition-based stats. Identities = 63/174 (36%), Positives = 86/174 (49%), Gaps = 20/174 (11%) Query: 1 MRIGHGFDVHA---------------FGGE----GPIIIGGVRIPYEKGLLAHSDGDVAL 41 +RIG G+D+H F + +GGV+I +L+HSDGD+ Sbjct: 64 IRIGQGYDIHKIKVLDEEYNTYANNDFNKNEQSFKTLTLGGVKINNVL-VLSHSDGDIIY 122 Query: 42 HALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQ 101 H++ D++LGA DIG LFPD D K +S LR A I K Y +GNVD+ +IAQ Sbjct: 123 HSIVDSILGALGSLDIGTLFPDKDEKNKNKNSAIFLRYARLLIYKKNYDIGNVDINVIAQ 182 Query: 102 APKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 PK+ + I+ L ++VK T EKLG G + I C A LLI Sbjct: 183 VPKISNIRKNIIKNISTVLNIDESQISVKGKTHEKLGVIGEKKAIECFANILLI 236 >UniRef50_B1VS88 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=93 Tax=Actinomycetales RepID=ISPF_STRGG Length = 172 Score = 183 bits (465), Expect = 2e-45, Method: Composition-based stats. Identities = 61/157 (38%), Positives = 88/157 (56%), Gaps = 4/157 (2%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYE-KGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 +G G D+HAF + G++ E GL HSD DV HA +AL AA LGD+G+ F Sbjct: 19 VGIGTDIHAFEEGRKLWCAGLKWEGEGPGLAGHSDADVVAHAACNALFSAAGLGDLGQHF 78 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 P + GA LL EA R ++A G+ +GNV V ++ PK+ + + ++E +G Sbjct: 79 GTGRPEWSGAAGITLLTEAARIVRAGGFEIGNVAVQVVGSRPKIGKRREEAQKVLSEAVG 138 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 V++ A T++ LGFTGRGEGIA A AL+ + Sbjct: 139 AP---VSLSAATSDGLGFTGRGEGIAGLATALVYRTA 172 >UniRef50_B1VIQ0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=10 Tax=Actinomycetales RepID=ISPF_CORU7 Length = 162 Score = 182 bits (462), Expect = 4e-45, Method: Composition-based stats. Identities = 58/156 (37%), Positives = 80/156 (51%), Gaps = 3/156 (1%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 R+G D H P + G+ G HSDGDV H + DALL A+ LGD+G Sbjct: 8 RVGIASDAHQVEPGKPCWMAGLLFEDADGCEGHSDGDVVSHVIVDALLSASGLGDLGSFV 67 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 + G L+ E + + G+T+GNV +I PKM P + + E +G Sbjct: 68 GVGRKEYDGVSGERLITECRQLLAENGFTIGNVAAQMIGNRPKMGPRREEAERRLTELVG 127 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 V+V ATTT+K+GFTGRGEG+A A A++ KA Sbjct: 128 AP---VSVSATTTDKMGFTGRGEGVAALATAVVWKA 160 >UniRef50_C1TMK1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TMK1_9BACT Length = 357 Score = 178 bits (452), Expect = 6e-44, Method: Composition-based stats. Identities = 59/158 (37%), Positives = 91/158 (57%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G GFDVH +++GGV +P GL HSD D+ H ++DA+LGAA L DIG++ Sbjct: 190 VRTGIGFDVHPLVPGRSLVLGGVEVPSPMGLDGHSDADIICHGISDAILGAAGLPDIGRV 249 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP D A+K ADS ELLRE +++ G+++ +DV + AQ P++ + ++ + Sbjct: 250 FPACDDAYKDADSYELLREVVSKVERCGWSIVWLDVVLHAQLPRIGETVIEITKNLDSVW 309 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 M VN+K + E +G G G + C AVA + + Sbjct: 310 NDGMRRVNLKVKSGEGVGSVGSGHCMMCYAVATIKNTS 347 >UniRef50_B9RCH5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Ricinus communis RepID=B9RCH5_RICCO Length = 230 Score = 176 bits (448), Expect = 2e-43, Method: Composition-based stats. Identities = 51/118 (43%), Positives = 71/118 (60%) Query: 38 DVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVT 97 DV LH + DA+LGA L DIG++FPD+DP +KGA S ++EA R + GY +GN+D T Sbjct: 71 DVLLHCVVDAILGALGLPDIGQIFPDSDPKWKGAPSSVFIKEAVRLMHEAGYDIGNLDAT 130 Query: 98 IIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 +I Q PK+ PH +R + E LG +N+KA T EK+ G IA V ++ Sbjct: 131 LILQRPKLSPHKEAIRSNLCELLGADPSVINLKAKTHEKVDSLGENRSIAAHTVMNVL 188 >UniRef50_C1CZ33 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Deinococci RepID=C1CZ33_DEIDV Length = 167 Score = 172 bits (437), Expect = 4e-42, Method: Composition-based stats. Identities = 59/137 (43%), Positives = 79/137 (57%), Gaps = 1/137 (0%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPY-EKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 RIG+G D H P+I+GGV IP+ E+G +AHSDGD LHA+ DALL ALGDIG Sbjct: 13 RIGYGEDAHRLARGLPLILGGVPIPHAEQGAVAHSDGDAVLHAVADALLSGLALGDIGHY 72 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDT +K DSR +L A ++A+GY NV + + PK+ P ++ +A L Sbjct: 73 FPDTAAEYKEMDSRIILDRALMLVRARGYAPVNVALVVTLDRPKLGPLRAEIAQTVAGLL 132 Query: 121 GCHMDDVNVKATTTEKL 137 +V V T+E L Sbjct: 133 DLPATEVGVSFKTSEGL 149 >UniRef50_C9M692 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase n=2 Tax=Synergistaceae RepID=C9M692_9BACT Length = 384 Score = 172 bits (436), Expect = 4e-42, Method: Composition-based stats. Identities = 50/142 (35%), Positives = 79/142 (55%), Gaps = 2/142 (1%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G G+DVH + P+++ GV +P GL HSD D+ H DA+L AA L DIG L Sbjct: 221 IRTGIGYDVHPLTPDRPLVLAGVTVPSPLGLAGHSDADIISHVAADAVLSAAGLPDIGTL 280 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 +P +D + G S +LL +A R + G+++ V + + AQ PK+ P+ P +R + + L Sbjct: 281 YPSSDEQYAGCRSMDLLADAVSRAEQAGWSVQFVSLVVTAQVPKLAPYGPAIRQALEKVL 340 Query: 121 GCHMDDVNVKATTTEKLGFTGR 142 G ++V + E +G G Sbjct: 341 GD--GKISVTFKSGESVGPVGE 360 >UniRef50_Q14PQ0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Spiroplasma citri RepID=Q14PQ0_SPICI Length = 152 Score = 172 bits (436), Expect = 5e-42, Method: Composition-based stats. Identities = 44/136 (32%), Positives = 81/136 (59%), Gaps = 3/136 (2%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MR+G+ +D+H +GG+ IP + + A SDGD+ LH +++A++GA LGD+G+ Sbjct: 1 MRVGNSYDLHNLKMGTGFYLGGILIPCQYQVEAVSDGDILLHTISEAIIGALGLGDLGEW 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 F +T+ +S+ +L++A + + Y + N+D TII P++ H ++ + + L Sbjct: 61 FDETNKK---INSQLILKKALTLMAEQNYQISNIDTTIIIDEPRLQKHKKAIKTNLQKLL 117 Query: 121 GCHMDDVNVKATTTEK 136 + +N+KATTTE+ Sbjct: 118 QISAEKINLKATTTEQ 133 >UniRef50_A9BHL8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Petrotoga mobilis SJ95 RepID=ISPF_PETMO Length = 162 Score = 171 bits (435), Expect = 6e-42, Method: Composition-based stats. Identities = 54/156 (34%), Positives = 81/156 (51%), Gaps = 4/156 (2%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYE--KGLLAHSDGDVALHALTDALLGAAALGDIG 58 ++IG G+DVH F +I+GGV I + GLL HSDGDV HAL D+LLG LG IG Sbjct: 2 LKIGFGYDVHPFAENRRLILGGVVINHPKGYGLLGHSDGDVFFHALIDSLLGMCGLGSIG 61 Query: 59 KLFPDTDPAFKGADSRELLREAWRRIQAKG-YTLGNVDVTIIAQAPKMLPHIPQMRVFIA 117 + FP++ F+ S LL + I + + N+DV II+++ + Q++ + Sbjct: 62 EYFPES-KEFENISSSILLEKTIDLINKRYIVKINNIDVVIISKSVNISSITGQIKNNTS 120 Query: 118 EDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVAL 153 L + +N+K + LG G +GI L Sbjct: 121 CILNLEVSRINLKGKSGNGLGVGGNDQGIEVYCTIL 156 >UniRef50_C5CGG7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=ISPF_KOSOT Length = 156 Score = 170 bits (433), Expect = 1e-41, Method: Composition-based stats. Identities = 56/157 (35%), Positives = 82/157 (52%), Gaps = 6/157 (3%) Query: 2 RIGHGFDVHAFGGEGP-IIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 R+G GFD H + +GGV++ E + HSDGD +HA+ DA+LGA G+IG Sbjct: 3 RVGIGFDAHPLEANKKGLYLGGVKVSEEYSSIGHSDGDALIHAIVDAILGATNAGNIGIW 62 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP+ +G S E L ++I A Y + N+D II +M PHI +R+ +A L Sbjct: 63 FPEN-EENRGRRSTEFLEIIRKKILAGKYEILNIDSVIIIDKVRMNPHIENIRLKLARIL 121 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 G ++NVK + G T G ++ AV +L K Sbjct: 122 GISKGNINVKPKS----GNTLYGNSVSVYAVCMLKKV 154 >UniRef50_B0BC71 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=18 Tax=Bacteria RepID=ISPF_CHLTB Length = 178 Score = 170 bits (431), Expect = 2e-41, Method: Composition-based stats. Identities = 52/161 (32%), Positives = 81/161 (50%), Gaps = 4/161 (2%) Query: 2 RIGHGFDVHAFGGE---GPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIG 58 R+G G D H F + P I+GG+ G A+SDGDV HA+ +A G +G Sbjct: 18 RVGIGQDSHRFLPDEDPKPCILGGIIFENTPGFEANSDGDVVFHAICNAFSSVTHKGILG 77 Query: 59 KLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAE 118 L + DS L+EA ++ + ++ +TI + PK+LP +P MR IAE Sbjct: 78 GLADELLKTKGITDSVVYLQEAIASLKPT-QRVSHLAITIEGKRPKLLPQLPSMRKRIAE 136 Query: 119 DLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 L +D +N+ AT+ E L G+G G+ C V +++ + Sbjct: 137 VLHIPLDSINITATSGEGLTAMGQGYGVQCFCVLTIMEYCR 177 >UniRef50_C7M1Q8 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7M1Q8_ACIFD Length = 364 Score = 165 bits (420), Expect = 3e-40, Method: Composition-based stats. Identities = 70/157 (44%), Positives = 93/157 (59%), Gaps = 6/157 (3%) Query: 1 MRIGHGFDVHAF--GGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIG 58 +R+G G D H P+++GGV +P GL AHSDGD HA+ DA+LGAA +G IG Sbjct: 205 VRVGLGLDQHPRSDEPGRPLVLGGVTVPGP-GLRAHSDGDALCHAVADAMLGAAGIGGIG 263 Query: 59 KLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAE 118 L+ DTDPAF+GADS ELL R ++ +G + VD TI+ + PK+ P++ +M I Sbjct: 264 DLYADTDPAFRGADSLELLAGCVRLVRGRGLRVVQVDATIVCETPKLSPYLARMARTIE- 322 Query: 119 DLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 G VKA E +G GRGEG+A AV LL Sbjct: 323 --GVVAAPALVKAKHPEGIGALGRGEGVAALAVVLLE 357 >UniRef50_B8I5R3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=6 Tax=Bacteria RepID=B8I5R3_CLOCE Length = 168 Score = 162 bits (410), Expect = 4e-39, Method: Composition-based stats. Identities = 52/156 (33%), Positives = 77/156 (49%), Gaps = 5/156 (3%) Query: 1 MRIGHGFDVHAF---GGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDI 57 M++G G D H F I+GGV L +SD DV LHALT+A+ G + + Sbjct: 13 MKVGIGQDSHRFDFQNNSKKFILGGVIFDDVTPLDGNSDADVVLHALTNAISGVTCVNIL 72 Query: 58 GKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIA 117 GK+ + DS E LREA + + + +V ++I PK+ P I +MR I+ Sbjct: 73 GKVSDEMCLERGITDSSEYLREALKYLVD--VKVVHVSISIECSYPKISPKIAEMRKSIS 130 Query: 118 EDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVAL 153 E LG + V + ATT E L G+G+G+ + Sbjct: 131 ELLGIPENCVGITATTGEGLTAFGQGKGVQAFCIVT 166 >UniRef50_Q83NK3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Tropheryma whipplei RepID=ISPDF_TROW8 Length = 422 Score = 159 bits (404), Expect = 2e-38, Method: Composition-based stats. Identities = 53/154 (34%), Positives = 77/154 (50%), Gaps = 3/154 (1%) Query: 3 IGHGFDVHAFG-GEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 IG G D H F E P+ + + + L HSDGDV HA T ALL AA +GDIG +F Sbjct: 269 IGVGIDFHKFILDESPLFLACLEWKNYRRLQGHSDGDVVAHACTTALLSAANMGDIGSVF 328 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 A K A L R + G+ + N+ V +I+ P++ + I++ L Sbjct: 329 GVDLAATKDASGAYFLESTNRLLATNGFCVLNIAVQVISNTPRLADRRVEAEHAISDCL- 387 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 +++ + TT+ +GF GRGEGI AVA + Sbjct: 388 -SGARISLSSVTTDGMGFLGRGEGIGAIAVAQIY 420 >UniRef50_A6LJL2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Thermosipho melanesiensis BI429 RepID=A6LJL2_THEM4 Length = 331 Score = 155 bits (394), Expect = 3e-37, Method: Composition-based stats. Identities = 46/152 (30%), Positives = 75/152 (49%), Gaps = 5/152 (3%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G G+D H E +++GGV I GL HSDGDV +H++ D+LLG + DIG LFP+ Sbjct: 183 GVGWDTHKIIKERKLVLGGVEIDSTFGLKGHSDGDVVIHSIIDSLLGVSLKKDIGVLFPE 242 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCH 123 + +G S +L+E + I KGY N+D +I ++ ++ + + + C Sbjct: 243 SKVP-EGISSVYMLQEVVKAINRKGYFPENIDCVVITDF-RLGSFRDEITKSLEKLVKCP 300 Query: 124 MDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 V++K T + I V+ +I Sbjct: 301 ---VSLKFKTGNGVYPEKNLNAITAICVSNII 329 >UniRef50_A7HN63 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Fervidobacterium nodosum Rt17-B1 RepID=A7HN63_FERNB Length = 326 Score = 155 bits (393), Expect = 4e-37, Method: Composition-based stats. Identities = 44/155 (28%), Positives = 75/155 (48%), Gaps = 5/155 (3%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 G G+D H ++IGGV I GLL HSD DV HA+ D+++G DIG LFP Sbjct: 177 TGIGWDTHPLVESRNLVIGGVDIESNMGLLGHSDADVLTHAIIDSIVGITHKKDIGVLFP 236 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 + + K S ++L E + + + G+ ++D II+ K+ + ++ + L C Sbjct: 237 EN-ESNKDRRSIDMLEEVTKYVISSGFFPSSIDCVIISPI-KLKDYREKITQNLENILNC 294 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 V+VK + + + +GI ++ + K Sbjct: 295 ---QVSVKFKSGNNVYPESQNKGITAICISNIDKI 326 >UniRef50_Q7NC56 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Mycoplasma gallisepticum RepID=ISPF_MYCGA Length = 157 Score = 153 bits (389), Expect = 1e-36, Method: Composition-based stats. Identities = 57/156 (36%), Positives = 88/156 (56%), Gaps = 9/156 (5%) Query: 1 MRIGHGFDVHAFG--GEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIG 58 +RIG GFD H + +GG+ + ++ L+A+SDGDV LHAL+DA+LG + GDIG Sbjct: 5 IRIGQGFDSHKLKTKKNSRVFLGGIPVRTDQQLIANSDGDVVLHALSDAVLGCGSFGDIG 64 Query: 59 KLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAE 118 F + D + KG DS+ +L + I+ N+D+TI AQ ++ P +++ + + Sbjct: 65 MYFDENDLSNKGLDSKTILNYCLKLIKKLKLEFVNIDLTIFAQDIRIDPIRFEIKSSLMK 124 Query: 119 DLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 GC + VNVKA + E + E IAC V L+ Sbjct: 125 LTGC--NSVNVKAKSYE----EPKNE-IACSCVVLM 153 >UniRef50_B7IFV0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Thermosipho africanus TCF52B RepID=B7IFV0_THEAB Length = 332 Score = 150 bits (381), Expect = 1e-35, Method: Composition-based stats. Identities = 40/152 (26%), Positives = 75/152 (49%), Gaps = 5/152 (3%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G G+D H + +I+GGV I + GL HSD DV +H++ D+ +G + DIG+LFP+ Sbjct: 184 GIGWDTHPIKKDRKLILGGVEIESDIGLDGHSDADVLIHSIVDSFVGVSLKKDIGELFPE 243 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCH 123 D KG S +L + ++ G+ +VD +I ++ + ++ + + + C Sbjct: 244 KDVP-KGISSVFILENVLKSMKENGFFPESVDCVLITDF-RLGKYRAEISKNLEKIINCP 301 Query: 124 MDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 V++K T + + + V+ +I Sbjct: 302 ---VSIKFKTGNNVYPETNLKAMTAMCVSNII 330 >UniRef50_Q8EUA4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Mycoplasma penetrans RepID=Q8EUA4_MYCPE Length = 165 Score = 146 bits (369), Expect = 3e-34, Method: Composition-based stats. Identities = 48/156 (30%), Positives = 81/156 (51%), Gaps = 8/156 (5%) Query: 2 RIGHGFDVHAFGGEG-PIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +IG+G D+H E + G+ + ++AHSDGD+ LH+++ A+LGA +L D+G Sbjct: 17 KIGNGIDIHKIKKEKCKQRLAGLDFELDYKIIAHSDGDIILHSISSAILGALSLQDLGTY 76 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 F DTD K DS E+L ++ + Y++ NVD+TII + Q++ + + L Sbjct: 77 FSDTDSKNKNLDSLEILSMCLNELKKQDYSISNVDITIICEYIIFKDIKDQIKSNLEKLL 136 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 ++++KAT E+ I V L+ K Sbjct: 137 NN--TEISLKATRYEE-----DKNMIQVNTVLLINK 165 >UniRef50_C5BMS2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Teredinibacter turnerae T7901 RepID=C5BMS2_TERTT Length = 157 Score = 145 bits (368), Expect = 3e-34, Method: Composition-based stats. Identities = 44/130 (33%), Positives = 68/130 (52%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIGHG +++GGV + GL +DGD+ L A+ DAL GAA LG+ L Sbjct: 1 MRIGHGIVCAQRTQARKLVLGGVYLEPGFGLAIMNDGDLLLAAVGDALAGAAGLGNFVSL 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 + T P FK A +R LL+ +++KG N+D+++ + + M+ IA+ L Sbjct: 61 YDLTSPDFKHASTRSLLQMLATSLRSKGLRTVNLDISLCGRDLIFNAYRDDMQASIADAL 120 Query: 121 GCHMDDVNVK 130 G +N+K Sbjct: 121 GIDATRINLK 130 >UniRef50_A7AVQ2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Babesia bovis RepID=A7AVQ2_BABBO Length = 199 Score = 141 bits (356), Expect = 7e-33, Method: Composition-based stats. Identities = 61/162 (37%), Positives = 87/162 (53%), Gaps = 7/162 (4%) Query: 2 RIGHGFDVHAFGG----EGPIIIGGVRIPYEK-GLLAHSDGDVALHALTDALLGAAALGD 56 RIG G+D+H G P +GGV + K ++ HSDGD LHAL DALLGA GD Sbjct: 39 RIGLGYDIHRLVGTGKGGKPFKLGGVLVDDSKIFVVGHSDGDTLLHALADALLGATGCGD 98 Query: 57 IGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPH-IPQMRVF 115 IG F + D K DSR +L A + +GY N+D+ II + ++ ++ Sbjct: 99 IGDYFSELDSINKDMDSRIILESAIKEASLRGYRPTNIDINIILERVRLGRRLKDAIKKA 158 Query: 116 IAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 + + LG + +NVKA T E L GRGE ++C+ +A L + Sbjct: 159 LYDMLGSDV-MINVKAKTNEGLDAIGRGEAVSCQVIAHLKRI 199 >UniRef50_UPI0001913A58 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Salmonella enterica subsp. enterica serovar Typhi RepID=UPI0001913A58 Length = 128 Score = 138 bits (350), Expect = 4e-32, Method: Composition-based stats. Identities = 85/88 (96%), Positives = 86/88 (97%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL Sbjct: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKG 88 FPDTDPAFKGADSRELLREAWRRIQ + Sbjct: 61 FPDTDPAFKGADSRELLREAWRRIQPRD 88 >UniRef50_B5Y8V5 Bifunctional enzyme IspD/ispF n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5Y8V5_COPPD Length = 362 Score = 131 bits (331), Expect = 7e-30, Method: Composition-based stats. Identities = 44/135 (32%), Positives = 71/135 (52%), Gaps = 5/135 (3%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPY-EKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 G G+D H F P+I+GGVRI + GL + +DGDV +HA+ DALL GD+G L+P Sbjct: 211 GIGWDFHRFSENAPLILGGVRIEDADVGLESWTDGDVIIHAVADALLSTLGQGDLGTLYP 270 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 ++ +KG S ++L + R++ K L V ++A P + I + ++ L Sbjct: 271 NSQL-WKGGSSTDILADVMERMRKKHVLLEKATVLLLADKPMLKHWIDPITRNLSSLLNA 329 Query: 123 HMDDVNVKATTTEKL 137 V + T +E + Sbjct: 330 P---VYLSVTRSEGI 341 >UniRef50_C2BUI0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Mobiluncus RepID=C2BUI0_9ACTO Length = 195 Score = 122 bits (306), Expect = 5e-27, Method: Composition-based stats. Identities = 63/161 (39%), Positives = 86/161 (53%), Gaps = 8/161 (4%) Query: 1 MRIGHGFDVHAFGGE-----GPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALG 55 R+G GFD H F P+ +G + P L HSDGDVA HALTDALL AA LG Sbjct: 37 FRVGQGFDAHRFAAGAPVVGRPLRVGTLSFPDHAPLEGHSDGDVAAHALTDALLAAAGLG 96 Query: 56 DIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVF 115 D+G F + P + GA LR A R + G+ + N VT++ Q P++ H + Sbjct: 97 DLGTNFGVSRPEYAGASGEVFLRAAMRMLHETGWVVVNASVTVVGQEPRLGSHYAEAEAA 156 Query: 116 IAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 + L V+ ATTT+++GFTG EG+A A+ LL + Sbjct: 157 LGNILAAP---VSFSATTTDRMGFTGNKEGLAALAICLLRR 194 >UniRef50_B7GT04 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=14 Tax=Bifidobacterium RepID=ISPF_BIFLI Length = 174 Score = 118 bits (298), Expect = 4e-26, Method: Composition-based stats. Identities = 67/170 (39%), Positives = 85/170 (50%), Gaps = 18/170 (10%) Query: 3 IGHGFDVHAFGG---EGPIIIGGVRIPYEK-----------GLLAHSDGDVALHALTDAL 48 IG GFD H F + I G+ P G+ SDGDVA HAL DAL Sbjct: 8 IGQGFDAHRFAPAGSGRELWIAGLYWPVPDSCSEADAARYEGIEGDSDGDVAAHALIDAL 67 Query: 49 LGAAALGDIGKLFPDT-DPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLP 107 L AA LGDIG LF D G ++L+E + + GYT + V II PK+ Sbjct: 68 LAAARLGDIGSLFGVGADAHGAGRHGIDMLQEVVAHLASNGYTPASASVAIIGNRPKIGT 127 Query: 108 HIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 + ++ +GC V+V ATTT+ +GFTGRGEGIA A AL+ K Sbjct: 128 RRAEAEAALSAAVGCP---VSVTATTTDHMGFTGRGEGIAAIANALVEKI 174 >UniRef50_Q0PH58 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (Fragment) n=1 Tax=Toxoplasma gondii RepID=Q0PH58_TOXGO Length = 91 Score = 115 bits (288), Expect = 6e-25, Method: Composition-based stats. Identities = 43/91 (47%), Positives = 58/91 (63%), Gaps = 3/91 (3%) Query: 33 AHSDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAK--GYT 90 AHSDGDV LHA+ DA+ GA ALGDIG+ F D++PAF+G S L+ A ++AK + Sbjct: 1 AHSDGDVLLHAVCDAVFGAFALGDIGEHFSDSNPAFRGMSSSILVARALEIVRAKHPDWR 60 Query: 91 LGNVDVTIIAQAPKML-PHIPQMRVFIAEDL 120 LG+VD T++ A K +MR +AE L Sbjct: 61 LGSVDATVVFDAMKFGRARKQKMRENLAELL 91 >UniRef50_Q0PH60 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (Fragment) n=1 Tax=Eimeria tenella RepID=Q0PH60_EIMTE Length = 87 Score = 96.2 bits (239), Expect = 3e-19, Method: Composition-based stats. Identities = 35/86 (40%), Positives = 47/86 (54%) Query: 57 IGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFI 116 IG+ FPDT KG +SRE + A A GYT+ VDVT++ Q P++ QM + Sbjct: 2 IGQPFPDTAAENKGRNSREFVAAAVAAAAAAGYTVAQVDVTLMLQRPRISSKKQQMIDTL 61 Query: 117 AEDLGCHMDDVNVKATTTEKLGFTGR 142 A LG V++KA T E +G GR Sbjct: 62 AAALGISSSKVSLKAKTGEGVGPVGR 87 >UniRef50_UPI0001B44793 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Listeria monocytogenes FSL J1-208 RepID=UPI0001B44793 Length = 62 Score = 82.3 bits (203), Expect = 4e-15, Method: Composition-based stats. Identities = 31/59 (52%), Positives = 42/59 (71%) Query: 98 IIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 ++ ++ KM P++ Q+++ IAE L VNVKATTTEKLGFTGR EGIA A+ L+ K Sbjct: 4 LLLKSQKMAPYVEQIKLRIAELLHADSAQVNVKATTTEKLGFTGREEGIASLAIVLIEK 62 >UniRef50_Q49436 Uncharacterized protein MG459 n=2 Tax=Mycoplasma RepID=Y459_MYCGE Length = 169 Score = 76.2 bits (187), Expect = 3e-13, Method: Composition-based stats. Identities = 47/176 (26%), Positives = 73/176 (41%), Gaps = 29/176 (16%) Query: 1 MRIGHGFD-VH---AFGGEGPIIIGGVRIPYEKGL--LAHSD--GDVALHALTDALLGAA 52 +R+G G H + +GGV K + L +SD DV A+ DAL GA Sbjct: 3 LRVGLGSKKYHIKLRKESKNKFWLGGVDFENSKYIYDLENSDEVSDVIQLAVADALFGAT 62 Query: 53 ALGD--IGKLFPDTDPAFKGADSRE---LLREAWRRIQAKGYTLGNVDVTI-IAQAPKML 106 ALGD I + FKG +E +L + I+ K + + N+D+++ I Q K+ Sbjct: 63 ALGDGHIVFNKGKSTVQFKGTAKKEAPRVLARTYNFIR-KNWIINNIDISLEIPQEQKVD 121 Query: 107 PHIPQMRVFIAEDLGCHMDDVNVKAT----TTEKLGFTGRGEGIACEAVALLIKAT 158 + + FI L +N+K + E I C AV L+ + Sbjct: 122 DYKHAIFAFICSALRISELTINLKVRKPLDSNE----------INCLAVVLVERQK 167 >UniRef50_UPI0001699D05 tRNA pseudouridine synthase D n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2' RepID=UPI0001699D05 Length = 101 Score = 49.2 bits (117), Expect = 4e-05, Method: Composition-based stats. Identities = 16/30 (53%), Positives = 23/30 (76%) Query: 112 MRVFIAEDLGCHMDDVNVKATTTEKLGFTG 141 MR +A DL ++ ++VKATTTE++GFTG Sbjct: 1 MRAHLANDLKIDVNQISVKATTTERMGFTG 30 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_D1PLD9 IspD/IspF enzyme n=2 Tax=Firmicutes RepID=D1PLD9... 261 4e-69 UniRef50_D2RJ59 2C-methyl-D-erythritol 2,4-cyclodiphosphate synt... 256 1e-67 UniRef50_C6LHN9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 249 1e-65 UniRef50_Q1LLZ4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 247 8e-65 UniRef50_B2K578 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 246 2e-64 UniRef50_C4Z8W9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 246 2e-64 UniRef50_Q21YT7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 246 3e-64 UniRef50_C4Z3N3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 244 5e-64 UniRef50_Q18CD3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 244 9e-64 UniRef50_Q7VFU3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 243 1e-63 UniRef50_Q9CAK8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 242 4e-63 UniRef50_Q2NAE1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 241 4e-63 UniRef50_C9KNS3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 241 7e-63 UniRef50_B0TYX5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 241 8e-63 UniRef50_UPI000197A0EE bifunctional 2-C-methyl-D-erythritol 4-ph... 240 1e-62 UniRef50_C6XJQ8 2C-methyl-D-erythritol 2,4-cyclodiphosphate synt... 240 1e-62 UniRef50_A8LKV5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 239 2e-62 UniRef50_Q87DY3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 239 3e-62 UniRef50_A9KSM7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 239 3e-62 UniRef50_B7H1F3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 238 4e-62 UniRef50_Q2IW23 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 237 8e-62 UniRef50_Q6ARN9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 237 9e-62 UniRef50_A4WSL4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 236 2e-61 UniRef50_A5VQP4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 236 2e-61 UniRef50_Q1QU74 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 235 3e-61 UniRef50_Q487E8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 235 4e-61 UniRef50_Q2K8V5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 234 5e-61 UniRef50_C0R0Y4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 234 5e-61 UniRef50_B2JA49 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 234 7e-61 UniRef50_A0RN28 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 234 7e-61 UniRef50_C8PHW7 Bifunctional enzyme IspD/ispF n=1 Tax=Campylobac... 232 4e-60 UniRef50_Q5GSM7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 231 4e-60 UniRef50_C3XLN9 Bifunctional enzyme ispD/ispF n=1 Tax=Helicobact... 231 5e-60 UniRef50_A6U8F8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 231 6e-60 UniRef50_C1FJN6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 231 7e-60 UniRef50_B6YRV8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 229 2e-59 UniRef50_C9LKY7 IspD/IspF enzyme n=1 Tax=Dialister invisus DSM 1... 229 2e-59 UniRef50_C0QQE6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 229 3e-59 UniRef50_Q0BTD5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 228 4e-59 UniRef50_C5EY67 Bifunctional enzyme ispD/ispF n=2 Tax=Helicobact... 228 5e-59 UniRef50_D1BMU2 2-C-methyl-D-erythritol 4-phosphate cytidylyltra... 227 8e-59 UniRef50_Q1QM99 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 227 1e-58 UniRef50_A9BVX5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 227 1e-58 UniRef50_B1GYT3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 227 1e-58 UniRef50_B9JW91 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 226 2e-58 UniRef50_B8E112 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 226 2e-58 UniRef50_Q7MQW9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 226 3e-58 UniRef50_Q30QG7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 225 3e-58 UniRef50_Q1AU09 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 225 3e-58 UniRef50_B6DX86 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 225 4e-58 UniRef50_Q0APQ6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 224 1e-57 UniRef50_C7GYL8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 223 1e-57 UniRef50_Q9ZM19 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 221 7e-57 UniRef50_B1I0S9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 221 8e-57 UniRef50_A3ZYT9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 220 1e-56 UniRef50_D1CCF0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 219 2e-56 UniRef50_Q2GER2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 219 4e-56 UniRef50_C3XI64 Bifunctional 2-C-methyl-D-erythritol 4-phosphate... 217 7e-56 UniRef50_Q4FM31 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 216 1e-55 UniRef50_Q310X3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 216 2e-55 UniRef50_C6BS25 2-C-methyl-D-erythritol 4-phosphate cytidylyltra... 216 2e-55 UniRef50_B0SAT2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 214 9e-55 UniRef50_B8D9J7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 214 9e-55 UniRef50_B2URI3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 213 1e-54 UniRef50_Q5P993 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 213 2e-54 UniRef50_A5V2U9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 212 4e-54 UniRef50_D1B5E2 2C-methyl-D-erythritol 2,4-cyclodiphosphate synt... 211 5e-54 UniRef50_B9KAZ0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 211 7e-54 UniRef50_B8CD73 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 207 7e-53 UniRef50_C1F762 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 207 7e-53 UniRef50_A7HDA2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 207 1e-52 UniRef50_Q73KC6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 206 2e-52 UniRef50_Q2RFM1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 206 2e-52 UniRef50_Q1MR76 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 206 2e-52 UniRef50_Q1IVA8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 204 6e-52 UniRef50_B2KDX1 2-C-methyl-D-erythritol 4-phosphate cytidylyltra... 202 2e-51 UniRef50_B1L8F8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 202 3e-51 UniRef50_B7FYU1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 202 4e-51 UniRef50_A8F4L5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 202 4e-51 UniRef50_B1Q2Q5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 201 7e-51 UniRef50_Q4MZY9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 200 1e-50 UniRef50_C4XSW4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 199 2e-50 UniRef50_C4RE02 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 199 2e-50 UniRef50_Q72HP8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 195 3e-49 UniRef50_C8R0Y1 2-C-methyl-D-erythritol 4-phosphate cytidylyltra... 192 2e-48 UniRef50_D0RP30 Bifunctional enzyme IspD/ispF n=1 Tax=alpha prot... 190 9e-48 UniRef50_B3L0R0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 189 2e-47 UniRef50_A5CTY4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 188 4e-47 UniRef50_C1TMK1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 187 9e-47 UniRef50_B4U9N6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 186 2e-46 UniRef50_B1VS88 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 185 3e-46 UniRef50_Q1QBM3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 184 7e-46 UniRef50_P62368 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 184 8e-46 UniRef50_B6KAQ3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 183 1e-45 UniRef50_B1VIQ0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 183 2e-45 UniRef50_B9RCH5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 179 3e-44 UniRef50_C1CZ33 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 178 4e-44 UniRef50_C9M692 2-C-methyl-D-erythritol 4-phosphate cytidylyltra... 176 2e-43 UniRef50_Q14PQ0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 173 2e-42 UniRef50_A9BHL8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 173 2e-42 UniRef50_C7M1Q8 2-C-methyl-D-erythritol 4-phosphate cytidylyltra... 172 4e-42 UniRef50_A6LJL2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 167 8e-41 UniRef50_C5CGG7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 167 9e-41 UniRef50_A7HN63 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 167 9e-41 UniRef50_B0BC71 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 165 3e-40 UniRef50_B7IFV0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 163 1e-39 UniRef50_B8I5R3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 162 5e-39 UniRef50_Q83NK3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 161 7e-39 UniRef50_Q7NC56 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 154 7e-37 UniRef50_Q8EUA4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 154 1e-36 UniRef50_A7AVQ2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 143 1e-33 UniRef50_B5Y8V5 Bifunctional enzyme IspD/ispF n=1 Tax=Coprotherm... 142 5e-33 UniRef50_C5BMS2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 138 6e-32 UniRef50_UPI0001913A58 2-C-methyl-D-erythritol 2,4-cyclodiphosph... 137 1e-31 UniRef50_C2BUI0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 125 6e-28 UniRef50_B7GT04 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 121 9e-27 UniRef50_Q0PH58 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 115 5e-25 UniRef50_Q49436 Uncharacterized protein MG459 n=2 Tax=Mycoplasma... 114 1e-24 UniRef50_Q0PH60 2-C-methyl-D-erythritol 2,4-cyclodiphosphate syn... 98 7e-20 UniRef50_UPI0001B44793 2-C-methyl-D-erythritol 2,4-cyclodiphosph... 82 8e-15 UniRef50_UPI0001699D05 tRNA pseudouridine synthase D n=1 Tax=End... 48 7e-05 Sequences not found previously or not previously below threshold: CONVERGED! >UniRef50_D1PLD9 IspD/IspF enzyme n=2 Tax=Firmicutes RepID=D1PLD9_9FIRM Length = 400 Score = 261 bits (669), Expect = 4e-69, Method: Composition-based stats. Identities = 97/156 (62%), Positives = 114/156 (73%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIGHG+DVH +I+GGV IPYEKGLL HSD DV LHA+ DA+LGAAALGDIGK Sbjct: 245 MRIGHGYDVHQLVEGRKLILGGVEIPYEKGLLGHSDADVLLHAIMDAVLGAAALGDIGKH 304 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTDPA+KGADS L R ++ +GY++GN+D TI+ QAPK+ PHIP MR IAE Sbjct: 305 FPDTDPAYKGADSLALTRAVAGLVREQGYSVGNIDSTILCQAPKLAPHIPAMRAHIAEAF 364 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 G +D V+VKATT E +GFTG G GIA AV LL Sbjct: 365 GIPLDAVSVKATTEEHMGFTGEGRGIAAHAVVLLEN 400 >UniRef50_D2RJ59 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RJ59_ACIFE Length = 395 Score = 256 bits (656), Expect = 1e-67, Method: Composition-based stats. Identities = 95/156 (60%), Positives = 115/156 (73%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 RIG G+DVH P+I+ GV +P+++GL HSD DVALHAL DALLGAA +GDIG+L Sbjct: 240 FRIGSGYDVHRLVEGRPLILCGVTVPWDRGLDGHSDADVALHALMDALLGAAGMGDIGRL 299 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD A+ GADSR+LL +++A G+ + NVDVTIIAQ PK+ P+ P M + DL Sbjct: 300 FPDTDDAYLGADSRKLLAAVLEKLRAAGWQVNNVDVTIIAQRPKLAPYEPAMLENLLTDL 359 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 G D VNVKATTTEKLGFTGRGEGIA EAVA L + Sbjct: 360 GLPRDAVNVKATTTEKLGFTGRGEGIAAEAVASLTR 395 >UniRef50_C6LHN9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Bryantella formatexigens DSM 14469 RepID=C6LHN9_9FIRM Length = 226 Score = 249 bits (638), Expect = 1e-65, Method: Composition-based stats. Identities = 87/155 (56%), Positives = 109/155 (70%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MR+G G+DVH +I+ GV IPYEKGLL HSD DVA+HA+ DALLGAAALGDIGK Sbjct: 40 MRVGMGYDVHRLTEGRKLILCGVEIPYEKGLLGHSDADVAVHAIMDALLGAAALGDIGKH 99 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD + G S LL+ ++ Y + N+D TIIAQ PK+LP++PQM +AE L Sbjct: 100 FPDTDAQYAGISSILLLKRVGDLLEENNYIIENIDATIIAQRPKLLPYMPQMVKNVAEAL 159 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 G + VN+KATT E LGFTG GEGI+ +A+ LL+ Sbjct: 160 GIEENQVNIKATTEEGLGFTGNGEGISAQAICLLM 194 >UniRef50_Q1LLZ4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=60 Tax=Bacteria RepID=ISPF_RALME Length = 168 Score = 247 bits (632), Expect = 8e-65, Method: Composition-based stats. Identities = 93/156 (59%), Positives = 113/156 (72%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIG G+DVHA +I+GGV IP+++GLL HSD D LHA+TDAL GAAALGDIG+ Sbjct: 6 IRIGQGYDVHALVPGRKLILGGVDIPHDRGLLGHSDADALLHAVTDALFGAAALGDIGRH 65 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTDP F GADSR LLREA RR++ GY +GNVD T+IAQ PK+ PHI M +AEDL Sbjct: 66 FPDTDPNFAGADSRVLLREAVRRVREAGYEIGNVDATVIAQKPKLAPHISGMVANLAEDL 125 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 G + NVKA T EKLGF G+ EGI +A L+ + Sbjct: 126 GLPVTRCNVKAKTNEKLGFEGKEEGIVAQAAVLIYR 161 >UniRef50_B2K578 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=32 Tax=Bacteria RepID=ISPF_YERPB Length = 162 Score = 246 bits (629), Expect = 2e-64, Method: Composition-based stats. Identities = 135/161 (83%), Positives = 144/161 (89%), Gaps = 2/161 (1%) Query: 1 MRIGHGFDVHAFGGEG--PIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIG 58 MRIGHGFDVH FG G P+IIGGVRIPYEKGLLAHSDGDVALHA TDALLGAAALGDIG Sbjct: 1 MRIGHGFDVHKFGENGSGPLIIGGVRIPYEKGLLAHSDGDVALHAATDALLGAAALGDIG 60 Query: 59 KLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAE 118 KLFPDTDPAFKGADSR LLREA+R I AKGY LGN+D+TIIAQAPKM PHIPQMRV +AE Sbjct: 61 KLFPDTDPAFKGADSRGLLREAYRCILAKGYKLGNLDITIIAQAPKMAPHIPQMRVNLAE 120 Query: 119 DLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 DL CHMDD+NVKATTTE+LGFTGRGEGIACEAV LL+ + Sbjct: 121 DLQCHMDDINVKATTTEQLGFTGRGEGIACEAVVLLVNVEQ 161 >UniRef50_C4Z8W9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=38 Tax=cellular organisms RepID=ISPF_EUBR3 Length = 177 Score = 246 bits (628), Expect = 2e-64, Method: Composition-based stats. Identities = 85/154 (55%), Positives = 107/154 (69%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MR+G G+DVH +I+GGV++P+ GLL HSD DV LHA+ DALLGAAALGDIGK Sbjct: 1 MRVGMGYDVHKLVEGRDLILGGVKVPHTLGLLGHSDADVLLHAIMDALLGAAALGDIGKH 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTDPA++G S +LL I KGY + N+D T+IAQ PK+ P+I QM +A+ L Sbjct: 61 FPDTDPAYEGISSLKLLEHVRDLIAKKGYVIENIDATVIAQKPKLRPYIEQMEQNVADTL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 + VN+KATT E LGFTGR EGIA +A+ L Sbjct: 121 QIAKEQVNIKATTEEWLGFTGREEGIASQAICSL 154 >UniRef50_Q21YT7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=175 Tax=Bacteria RepID=ISPDF_RHOFD Length = 418 Score = 246 bits (628), Expect = 3e-64, Method: Composition-based stats. Identities = 91/156 (58%), Positives = 110/156 (70%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 RIG G+D+HA +++GGV IPY GLL HSD DV LHA+TDALLGAAALGDIG Sbjct: 261 FRIGEGWDIHALVAGRKLLLGGVEIPYHLGLLGHSDADVLLHAITDALLGAAALGDIGTH 320 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD FKGADS LL EA RR++AKG+ +GNVD T+IAQAPK++P++ MR IA L Sbjct: 321 FPDTDARFKGADSLVLLTEAARRVRAKGFEIGNVDSTVIAQAPKLMPYMAAMRAQIALAL 380 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 +D VNVKA T EK+G G G+ + A LL K Sbjct: 381 ALEVDQVNVKAKTAEKMGPVGLGQAMEARATVLLRK 416 >UniRef50_C4Z3N3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=426 Tax=cellular organisms RepID=ISPF_EUBE2 Length = 183 Score = 244 bits (625), Expect = 5e-64, Method: Composition-based stats. Identities = 90/158 (56%), Positives = 109/158 (68%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MR+G G+DVH + +I+GGV IPYE GLL HSD DV LHA+ DALLGAAALGDIGK Sbjct: 1 MRVGMGYDVHKLVKDRKLIMGGVEIPYELGLLGHSDADVLLHAIMDALLGAAALGDIGKH 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD +KG S +LL E ++I Y + N+D TIIAQ PKM P+I MR IA+ L Sbjct: 61 FPDTDDRYKGISSIKLLEEVGKKIDEANYIIENIDATIIAQKPKMRPYIDDMRKNIADAL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 +D VNVKATT E LGFTG GEGI+ +A+ L + Sbjct: 121 KIDVDRVNVKATTEEGLGFTGSGEGISSQAICSLNSVS 158 >UniRef50_Q18CD3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=116 Tax=Bacteria RepID=ISPF_CLOD6 Length = 161 Score = 244 bits (623), Expect = 9e-64, Method: Composition-based stats. Identities = 87/159 (54%), Positives = 117/159 (73%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIG G+DVH + +IIGGV IP++KGLL HSD DV +HA+ D++LGA ALGDIGK Sbjct: 1 MRIGLGYDVHKLTEDRKLIIGGVEIPHDKGLLGHSDADVLIHAIMDSILGALALGDIGKH 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD +KGADS +LL + I +KGY +GN+D TIIAQ+PKM P+I MR I++ L Sbjct: 61 FPDTDEEYKGADSMKLLEHVYNLITSKGYKIGNIDSTIIAQSPKMAPYIESMRSNISKVL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 +D++N+KATT E LGFTG +GIA +++ LL+ ++ Sbjct: 121 NTDIDNINIKATTEEGLGFTGAKQGIASQSICLLLLTSQ 159 >UniRef50_Q7VFU3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Campylobacterales RepID=ISPDF_HELHP Length = 389 Score = 243 bits (622), Expect = 1e-63, Method: Composition-based stats. Identities = 77/154 (50%), Positives = 97/154 (62%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 + IG+G DVH F + +GGV I G AHSDGDV LHAL+DA+LGA GDIG+ Sbjct: 223 VFIGNGIDVHQFEKNKQMWLGGVEIESPFGFKAHSDGDVVLHALSDAILGAIGGGDIGEW 282 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD +K ADS+ +L E + Q+ GY L N D++IIAQ PK+ P+ MR IA L Sbjct: 283 FPDTDETYKNADSKMMLSEIYTFAQSVGYELYNADISIIAQTPKIAPYKSAMRECIARIL 342 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 +N+KATTTE LGF GR EG+ EA + Sbjct: 343 RVPNAHINIKATTTEGLGFVGREEGVCVEACVSM 376 >UniRef50_Q9CAK8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, chloroplastic n=38 Tax=Viridiplantae RepID=ISPF_ARATH Length = 231 Score = 242 bits (618), Expect = 4e-63, Method: Composition-based stats. Identities = 75/157 (47%), Positives = 101/157 (64%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 RIGHGFD+H P+IIGG+ IP+++G AHSDGDV LH + DA+LGA L DIG++ Sbjct: 75 FRIGHGFDLHRLEPGYPLIIGGIVIPHDRGCEAHSDGDVLLHCVVDAILGALGLPDIGQI 134 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPD+DP +KGA S ++EA R + GY +GN+D T+I Q PK+ PH +R +++ L Sbjct: 135 FPDSDPKWKGAASSVFIKEAVRLMDEAGYEIGNLDATLILQRPKISPHKETIRSNLSKLL 194 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 G VN+KA T EK+ G IA V LL+K Sbjct: 195 GADPSVVNLKAKTHEKVDSLGENRSIAAHTVILLMKK 231 >UniRef50_Q2NAE1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=7 Tax=Bacteria RepID=ISPDF_ERYLH Length = 386 Score = 241 bits (617), Expect = 4e-63, Method: Composition-based stats. Identities = 80/157 (50%), Positives = 106/157 (67%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R+G GFDVH + +GG+R+ ++KGL HSD DVALHA+ DALLGA GDIG Sbjct: 226 VRVGTGFDVHKLEAGEELWLGGIRLEHDKGLAGHSDADVALHAIVDALLGAIGKGDIGDH 285 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA S + A + + GY +GN+D+TII +AP++ PH M IAE L Sbjct: 286 FPPSDPQWKGAASSAFIEHAAKLVDEAGYRVGNIDLTIICEAPRIGPHRDAMGQRIAELL 345 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 D ++VKATTTEKLGFTGRGEGIA +A A +++ Sbjct: 346 ATSPDAISVKATTTEKLGFTGRGEGIAAQAAATVVRK 382 >UniRef50_C9KNS3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KNS3_9FIRM Length = 158 Score = 241 bits (615), Expect = 7e-63, Method: Composition-based stats. Identities = 94/155 (60%), Positives = 111/155 (71%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 R G G+DVH +IIGGV IP+ GLL HSD DV LHA++DALLGAAALGDIG+ F Sbjct: 3 RFGMGYDVHRLVEGRKLIIGGVEIPHALGLLGHSDADVLLHAISDALLGAAALGDIGRHF 62 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 PDTDP ++GADS +LL E R + KGY +GNVD TI+AQ PKM IP+M IA LG Sbjct: 63 PDTDPRYEGADSMKLLAEVRRLLAEKGYRIGNVDATIVAQKPKMKDFIPKMNENIATVLG 122 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 +DDVNVKATT EKLGFTG +GI+ AVA + K Sbjct: 123 VSLDDVNVKATTEEKLGFTGAEQGISAYAVAGIEK 157 >UniRef50_B0TYX5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=5 Tax=Gammaproteobacteria RepID=ISPF_FRAP2 Length = 159 Score = 241 bits (615), Expect = 8e-63, Method: Composition-based stats. Identities = 89/157 (56%), Positives = 110/157 (70%), Gaps = 1/157 (0%) Query: 1 MRIGHGFDVHAFGGEGP-IIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGK 59 RIGHG+DVH F II+GG+ IPYE GL AHSDGDV +HAL DA+LGA LGDIGK Sbjct: 3 FRIGHGYDVHKFTSTKKNIILGGIEIPYEMGLEAHSDGDVLIHALCDAILGALCLGDIGK 62 Query: 60 LFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAED 119 FPDTD +K DS+ L E + + K Y++ N+D TIIAQAPKMLPHI +M+ +A Sbjct: 63 HFPDTDMEYKNTDSKFFLAEIKKMLDDKEYSISNIDCTIIAQAPKMLPHIEKMKACLASV 122 Query: 120 LGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 L ++ +N+KATTTE+LGF GR EGIA V LL + Sbjct: 123 LEIQINQINIKATTTEQLGFIGRKEGIATHVVCLLNR 159 >UniRef50_UPI000197A0EE bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein n=1 Tax=Helicobacter cinaedi CCUG 18818 RepID=UPI000197A0EE Length = 401 Score = 240 bits (613), Expect = 1e-62, Method: Composition-based stats. Identities = 76/154 (49%), Positives = 104/154 (67%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 + +G+G DVH+F + +GGV+I G AHSDGDVALHAL+DA+LGA GDIG+ Sbjct: 225 VFVGNGIDVHSFEDNKEMWLGGVKIESSFGFKAHSDGDVALHALSDAILGAIGGGDIGQW 284 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPD++ A+K ADS++LL+ + + + GY L NVD++I+AQ PK+ P+ QMR IA L Sbjct: 285 FPDSNEAYKNADSKKLLQHIYDFVLSVGYELHNVDISIMAQTPKIAPYKSQMRECIARIL 344 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 VN+KATTTE LGF GR EG+ +A + Sbjct: 345 HLPKSRVNIKATTTESLGFVGRKEGVCVQASVSM 378 >UniRef50_C6XJQ8 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XJQ8_HIRBI Length = 387 Score = 240 bits (613), Expect = 1e-62, Method: Composition-based stats. Identities = 80/153 (52%), Positives = 102/153 (66%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 RIG+G+DVHAF + + G+ IP+ L HSD DVA HALTDA+ GA A GDIG F Sbjct: 231 RIGNGYDVHAFEDGQSVTLCGLEIPHSASLKGHSDADVAWHALTDAIYGALAEGDIGTHF 290 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 P +D +KGA S+ L+ A +KG+ + N D+TII +APK+ PH MR ++ LG Sbjct: 291 PPSDVKWKGAASKVFLKHAVELADSKGFMIANADITIICEAPKIKPHSMTMRDITSKILG 350 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 +D V+VKATTTEKLGFTGR EGIA +A LL Sbjct: 351 IPLDRVSVKATTTEKLGFTGRKEGIAAQASVLL 383 >UniRef50_A8LKV5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=16 Tax=Alphaproteobacteria RepID=ISPDF_DINSH Length = 400 Score = 239 bits (612), Expect = 2e-62, Method: Composition-based stats. Identities = 71/157 (45%), Positives = 105/157 (66%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G+G+DVH FG +I+ GV +P+++ L+ HSD DV +HA+TDA+ GA GDIG+ Sbjct: 244 IRTGNGYDVHRFGTGDAVILCGVEVPHDRALMGHSDADVGMHAVTDAIYGALGDGDIGQH 303 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA S LR A +GYT+ ++D T++ + PK+ P+ M+ ++E + Sbjct: 304 FPPSDPQWKGAASEIFLRHAVALAAERGYTITHMDCTLVCERPKIGPYHAVMKAKMSELM 363 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 G D V+VKATT+E+LGFTGR EGIA A L++ Sbjct: 364 GLQPDQVSVKATTSERLGFTGREEGIAALATVTLVRT 400 >UniRef50_Q87DY3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=9 Tax=Xylella fastidiosa RepID=ISPF_XYLFT Length = 176 Score = 239 bits (611), Expect = 3e-62, Method: Composition-based stats. Identities = 80/156 (51%), Positives = 109/156 (69%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIG G+DVHAFG +++GGVR+P+ G+LAHSDGDV LHAL DA+LGA LGDIG+ Sbjct: 15 VRIGQGYDVHAFGPSDHVMLGGVRVPHRCGVLAHSDGDVILHALCDAMLGALGLGDIGQH 74 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +D +KGADS +R ++ + + +GNVD T I ++PK+ P++ MR IA L Sbjct: 75 FPPSDVRWKGADSGVFVRHCNLLLRERDWCVGNVDATAICESPKIAPYVNAMREGIARLL 134 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 + V+VKATT+E LGF GRGEG+A + V LL + Sbjct: 135 EVQPECVSVKATTSEGLGFIGRGEGLAAQVVVLLYR 170 >UniRef50_A9KSM7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=5 Tax=Bacteria RepID=A9KSM7_CLOPH Length = 192 Score = 239 bits (611), Expect = 3e-62, Method: Composition-based stats. Identities = 86/154 (55%), Positives = 106/154 (68%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIG G+DVH +IIGGV +PYEKGLL HSD DV +HA+ DA+LGAAALGDIGK Sbjct: 1 MRIGMGYDVHKLVEGRDLIIGGVTVPYEKGLLGHSDADVLVHAIMDAILGAAALGDIGKH 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDT ++G S LL + ++ + Y +GN+D TIIAQ PKM +IPQM IA+ L Sbjct: 61 FPDTSKEYEGVSSIVLLEKVKELVEKECYIIGNIDATIIAQRPKMAQYIPQMVTNIAKTL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 VNVKATT E LGFTG G+GI+ +A+ LL Sbjct: 121 HISEKQVNVKATTEEGLGFTGSGDGISAQAICLL 154 >UniRef50_B7H1F3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=15 Tax=Bacteria RepID=ISPF_ACIB3 Length = 160 Score = 238 bits (609), Expect = 4e-62, Method: Composition-based stats. Identities = 85/154 (55%), Positives = 108/154 (70%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIG G DVHAF + + GV+IP+ GL AHSDGDV LHAL DALLGA ALGDIG+ Sbjct: 5 IRIGQGMDVHAFEEGNFVTLAGVQIPHTHGLKAHSDGDVVLHALCDALLGALALGDIGQH 64 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTDP FKGADSR LL+ ++ I +GY L N D+T+ + PK+ + +MR IA+ L Sbjct: 65 FPDTDPEFKGADSRVLLKHVYQLILDRGYHLNNADITVACERPKLAKYNLEMRQSIADVL 124 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 ++ +++KATTTEKLGFTGR EGI A L+ Sbjct: 125 NVDLNQISIKATTTEKLGFTGRQEGILATATVLI 158 >UniRef50_Q2IW23 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=10 Tax=Alphaproteobacteria RepID=ISPDF_RHOP2 Length = 401 Score = 237 bits (606), Expect = 8e-62, Method: Composition-based stats. Identities = 80/155 (51%), Positives = 105/155 (67%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G G+DVHAFG + + G+++P+ +G LAHSDGDV LHAL DA+LGA A GDIG Sbjct: 234 IRTGTGYDVHAFGDGDHVWLCGLKVPHNRGFLAHSDGDVGLHALVDAILGALADGDIGSH 293 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP TDP +KGA S + L+ A R+ A+G + N++VT+I + PK+ P MR IAE Sbjct: 294 FPPTDPQWKGAASDKFLKYAVDRVAARGGRIANLEVTMICERPKIGPLRDPMRQRIAEIT 353 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 G + V VKATT+E+LGFTGR EGIA A A + Sbjct: 354 GVPVSRVAVKATTSERLGFTGREEGIAATASATIR 388 >UniRef50_Q6ARN9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=4 Tax=Proteobacteria RepID=ISPDF_DESPS Length = 386 Score = 237 bits (606), Expect = 9e-62, Method: Composition-based stats. Identities = 81/156 (51%), Positives = 106/156 (67%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIGHGFD H + +I+GGV IPY GL HSD DV +HAL DALLGA GDIG+ Sbjct: 231 IRIGHGFDAHQLVEKRRLILGGVEIPYHLGLAGHSDADVLVHALCDALLGAIGAGDIGRH 290 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPD+ AFK S LL +++ Y +GN D+++I QAPK+ P++ QM+ IA Sbjct: 291 FPDSSDAFKDIYSIRLLESVMQKVGELNYKIGNADISVICQAPKLAPYLKQMQEIIATSC 350 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 C + D+N+KATTTEK+G+TGRGEGI+C AV LL + Sbjct: 351 ACQISDINIKATTTEKMGYTGRGEGISCHAVVLLQQ 386 >UniRef50_A4WSL4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=6 Tax=Rhodobacterales RepID=ISPF_RHOS5 Length = 159 Score = 236 bits (603), Expect = 2e-61, Method: Composition-based stats. Identities = 86/157 (54%), Positives = 111/157 (70%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G+GFDVHAFG + + GVR+P+ +GL+ HSD DV +HALTDA+ GA A GDIG Sbjct: 3 IRTGNGFDVHAFGPGDHVWLCGVRVPHHRGLIGHSDADVGMHALTDAIYGALAEGDIGVH 62 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA SR L A RI A+G+TL N DVT+I + PK+ P P MR +A + Sbjct: 63 FPPSDPQWKGAASRIFLEHAMGRIAARGFTLANCDVTLICERPKIGPMAPAMREALAAIM 122 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 G + ++VKATT+EKLGFTGR EGIAC A A L++A Sbjct: 123 GVEVGRISVKATTSEKLGFTGREEGIACIATATLLQA 159 >UniRef50_A5VQP4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=88 Tax=Proteobacteria RepID=ISPDF_BRUO2 Length = 409 Score = 236 bits (603), Expect = 2e-61, Method: Composition-based stats. Identities = 77/155 (49%), Positives = 101/155 (65%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G+G+DVH+F + + GV+IP+E L HSD DVALHALTDALL GDIG Sbjct: 248 IRTGNGYDVHSFEPGDHVTLCGVKIPHEAKLNGHSDADVALHALTDALLATRGAGDIGTH 307 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA SR + A + ++ G + NVDVT+I++APK+ PH M + + L Sbjct: 308 FPPSDPQWKGAASRIFIEHAAKIVREAGGRIANVDVTLISEAPKIGPHRAAMTQALCDML 367 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 G D V++KATT EKLGF GR EGIA A A +I Sbjct: 368 GIAADRVSIKATTNEKLGFVGRREGIAAIATATVI 402 >UniRef50_Q1QU74 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=14 Tax=Bacteria RepID=ISPF_CHRSD Length = 162 Score = 235 bits (601), Expect = 3e-61, Method: Composition-based stats. Identities = 101/155 (65%), Positives = 118/155 (76%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIGHGFDVH FG ++IGGVRIPY +G +AHSDGDV LHA+ DALLGA ALGDIG+ Sbjct: 3 LRIGHGFDVHRFGDGDHLMIGGVRIPYVQGFVAHSDGDVLLHAICDALLGACALGDIGRH 62 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD A+ GADSR+LLR + A GY + N+D T+IAQAP+M HIP MR IAEDL Sbjct: 63 FPDTDAAWAGADSRDLLRHVHTLVMAAGYAVANLDATVIAQAPRMAEHIPAMRACIAEDL 122 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 VNVKATT+E+LGFTGR EGIA EAV LL+ Sbjct: 123 DLDTTAVNVKATTSERLGFTGRKEGIAAEAVVLLM 157 >UniRef50_Q487E8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=49 Tax=Bacteria RepID=ISPF_COLP3 Length = 170 Score = 235 bits (600), Expect = 4e-61, Method: Composition-based stats. Identities = 96/155 (61%), Positives = 118/155 (76%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIGHGFDVH FGG+GP+++GGV+IP+E G +AHSDGDVA+HAL DA+LGA L DIG Sbjct: 1 MRIGHGFDVHKFGGKGPLVLGGVKIPFELGFIAHSDGDVAIHALCDAILGALCLADIGNH 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD ++ SR LLR + KG+ LGN D+TI+AQAPKM PH+ MR ++EDL Sbjct: 61 FPDTDGQYENISSRILLRHVVSLMTDKGFQLGNADITIVAQAPKMAPHLVAMRTCLSEDL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 ++ VNVKATTTEKLG+TGR EGI+ AV LLI Sbjct: 121 KTTIEQVNVKATTTEKLGYTGRKEGISVHAVVLLI 155 >UniRef50_Q2K8V5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=7 Tax=cellular organisms RepID=ISPDF_RHIEC Length = 406 Score = 234 bits (599), Expect = 5e-61, Method: Composition-based stats. Identities = 74/154 (48%), Positives = 101/154 (65%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G+G+DVH + + GV IP+++ L HSD DVALHALTDALL GDIG Sbjct: 246 VRTGNGYDVHQLEPGDGVTLCGVFIPHDQRLKGHSDADVALHALTDALLATCGAGDIGDH 305 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA S+ + A R ++ +G T+ N DV++IA+APK+ PH MR ++E L Sbjct: 306 FPPSDPQWKGAASKIFIEHAARIVRERGGTIMNADVSLIAEAPKVGPHREAMRARLSEYL 365 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 G ++ +VKATT EK+GF GR EGIA A A + Sbjct: 366 GIDIERCSVKATTNEKIGFVGRREGIAAIATATV 399 >UniRef50_C0R0Y4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Bacteria RepID=ISPF_BRAHW Length = 158 Score = 234 bits (599), Expect = 5e-61, Method: Composition-based stats. Identities = 73/158 (46%), Positives = 100/158 (63%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIG+G+D HAF +I+ G+ IPYE GL HSD D +HAL D++LGA ALGDIG Sbjct: 1 MRIGYGYDSHAFAENRKLILSGIEIPYELGLKGHSDADAVIHALIDSILGALALGDIGSH 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPD D +KG S LL + ++ K Y + N D+TII + PK+ +I MR +++ L Sbjct: 61 FPDNDSKYKGISSIVLLEKTVSIMEEKNYEISNTDITIILEKPKLRNYIDTMRENLSKIL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 +++V++KA T EK+ GRGEGIA V+LL K Sbjct: 121 KTDIENVSIKAKTNEKMDSIGRGEGIAVHCVSLLKKTK 158 >UniRef50_B2JA49 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=7 Tax=Bacteria RepID=ISPF_NOSP7 Length = 160 Score = 234 bits (598), Expect = 7e-61, Method: Composition-based stats. Identities = 75/156 (48%), Positives = 106/156 (67%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIG+G+D+H + +I+GG++IP+E GLL HSD DV HA+ DA+LGA +LGDIG Sbjct: 4 IRIGNGYDIHQLVSDRVLILGGIQIPHELGLLGHSDADVLTHAIMDAMLGALSLGDIGHY 63 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP + GADS LL + + I+ +G+ +GN+D ++A+ PK+ PHI MR +A L Sbjct: 64 FPPSDPKWAGADSLVLLNQVHQLIRDRGWQVGNIDSVVVAERPKLKPHIHNMRDKLAAIL 123 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 + + +KATT EKLG GR EGI AV LL+K Sbjct: 124 ELESNQIGIKATTNEKLGPVGREEGICAYAVVLLLK 159 >UniRef50_A0RN28 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=19 Tax=Campylobacter RepID=ISPDF_CAMFF Length = 372 Score = 234 bits (598), Expect = 7e-61, Method: Composition-based stats. Identities = 82/155 (52%), Positives = 106/155 (68%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 + G+GFDVHAF I + GV+IPY K +AHSDGDVALHAL DALLGAA+ DIG+L Sbjct: 210 IFCGNGFDVHAFKEGDFITLCGVKIPYSKAFIAHSDGDVALHALCDALLGAASAPDIGEL 269 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 +PD D FK DS+ LL+ + I++ G+ + N D+TIIAQ+PK+ P+ M +A+ L Sbjct: 270 YPDNDSKFKDIDSKILLQNSVNLIRSIGFDIINADITIIAQSPKISPYKDAMAKIVADIL 329 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 G + VN+KATTTE LGF GR EGIA A+ L Sbjct: 330 GIPLHKVNIKATTTEHLGFIGRNEGIAANAIVNLK 364 >UniRef50_C8PHW7 Bifunctional enzyme IspD/ispF n=1 Tax=Campylobacter gracilis RM3268 RepID=C8PHW7_9PROT Length = 440 Score = 232 bits (592), Expect = 4e-60, Method: Composition-based stats. Identities = 89/152 (58%), Positives = 109/152 (71%), Gaps = 2/152 (1%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G G+DVHA I++GGV+IP E L+AHSDGDVA+HAL DA+ GAA LGDIG+LFPD Sbjct: 277 GTGYDVHALEKGAGIMLGGVQIPCEFALIAHSDGDVAIHALIDAICGAAMLGDIGELFPD 336 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCH 123 +D KGADS+ELLR+ RR++ GY L N D+TIIAQ PK+ + QM+ ++E L C Sbjct: 337 SDAKLKGADSKELLRKVMRRVRGYGYELVNADITIIAQRPKIGAYKAQMQKVLSEILNC- 395 Query: 124 MDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 VNVKATTTE LGFTGR EGIA +A L Sbjct: 396 -ARVNVKATTTEGLGFTGRSEGIAAQAAVSLK 426 >UniRef50_Q5GSM7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=13 Tax=Rickettsiales RepID=ISPDF_WOLTR Length = 405 Score = 231 bits (591), Expect = 4e-60, Method: Composition-based stats. Identities = 73/162 (45%), Positives = 99/162 (61%), Gaps = 5/162 (3%) Query: 2 RIGHGFDVHAFGGEGP-----IIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGD 56 R+G G+D+H F I I GV I Y+ + AHSDGDVA+HA+ DA+LGA GD Sbjct: 240 RVGTGYDIHRFIKAQGKAKSFIKICGVEIEYDMKIEAHSDGDVAIHAVVDAILGALGCGD 299 Query: 57 IGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFI 116 IG FP + P +K +S L A ++ + KGY++ N+D+TI+ + PK+ P+ M+ FI Sbjct: 300 IGAHFPPSFPEWKDRNSSHFLDFAAKKAKEKGYSVSNLDITIVCEEPKISPYKVAMKKFI 359 Query: 117 AEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 ++ L + VNVKATTTEKLG GR EGI A LL K Sbjct: 360 SKTLEIDSEFVNVKATTTEKLGSIGRNEGILAHASVLLYKIA 401 >UniRef50_C3XLN9 Bifunctional enzyme ispD/ispF n=1 Tax=Helicobacter winghamensis ATCC BAA-430 RepID=C3XLN9_9HELI Length = 400 Score = 231 bits (591), Expect = 5e-60, Method: Composition-based stats. Identities = 80/153 (52%), Positives = 96/153 (62%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 +G G D+H I +GG+ I L+AHSDGDV LHAL DA+LGA GDIG+ FP Sbjct: 239 VGIGNDIHTLASGNGITLGGIFIDCPYQLIAHSDGDVCLHALCDAILGAIGAGDIGEWFP 298 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 D DP +KGADS+ELL+ GY+L VD+TI AQ PK+ P M IA+ LG Sbjct: 299 DNDPKYKGADSKELLQRIVDFTYNVGYSLKQVDITIFAQKPKISPFKKIMESQIAKLLGI 358 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 VNVKATTTEKLGF GRGEGI +A +L Sbjct: 359 PNFKVNVKATTTEKLGFVGRGEGIFAQANIVLE 391 >UniRef50_A6U8F8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=12 Tax=Proteobacteria RepID=ISPDF_SINMW Length = 404 Score = 231 bits (590), Expect = 6e-60, Method: Composition-based stats. Identities = 75/158 (47%), Positives = 102/158 (64%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G+G+DVH + + GV IP+++ L HSD DVALHALTDALL GDIG Sbjct: 243 VRTGNGYDVHQLVEGDGVTLCGVFIPHDRKLSGHSDADVALHALTDALLATCGAGDIGDH 302 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA S L A R ++ +G T+ + D+++IA+APK+ PH QMR ++ L Sbjct: 303 FPPSDPRWKGAPSHIFLEHAARIVRERGGTITHADISLIAEAPKVGPHRQQMRESLSAML 362 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 +D +VKATT EKLGF GR EGIA A A ++ A+ Sbjct: 363 AIAIDRCSVKATTNEKLGFVGRNEGIAAIATATVVYAS 400 >UniRef50_C1FJN6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Micromonas sp. RCC299 RepID=C1FJN6_9CHLO Length = 256 Score = 231 bits (589), Expect = 7e-60, Method: Composition-based stats. Identities = 72/164 (43%), Positives = 102/164 (62%), Gaps = 5/164 (3%) Query: 1 MRIGHGFDVHAFG-----GEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALG 55 MR+GHGFD+H + + +GG+++ +++G +AHSDGDV LH + DA+ GA L Sbjct: 60 MRVGHGFDLHRMELLSEMPDLELWLGGIKLEHDRGCVAHSDGDVLLHCVFDAITGALGLP 119 Query: 56 DIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVF 115 DIG+ FPD DP +KG S ++EA R ++ GY +GN+D TIIAQ PK+ PH ++ Sbjct: 120 DIGQCFPDNDPKWKGCTSDVFIKEAVRLMRDSGYEMGNIDCTIIAQRPKISPHKKAIKEN 179 Query: 116 IAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 +A+ L C VNVKA T EK+ G IAC V +L+KA Sbjct: 180 LAKLLECDEGLVNVKAKTHEKVDSLGENRSIACHTVCMLVKARS 223 >UniRef50_B6YRV8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=4 Tax=Bacteroidales RepID=ISPF_AZOPC Length = 167 Score = 229 bits (586), Expect = 2e-59, Method: Composition-based stats. Identities = 73/154 (47%), Positives = 103/154 (66%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIG G+DVH + +GG++IPYEKGL HSD DV +HAL DALLGAA +G+IG Sbjct: 3 IRIGFGYDVHPLVMNYNLWLGGIKIPYEKGLKGHSDADVLIHALCDALLGAADIGNIGTN 62 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP+T+ + DS+ LL++ I +K Y L N D+T+ + PK+ P IPQM+ +AE + Sbjct: 63 FPNTNKKLRNIDSKILLKQTMSFIYSKNYELNNADITVCIEQPKLNPFIPQMKTCLAEIM 122 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 ++++KATT+EK+GF GR EGIA A L+ Sbjct: 123 QTDKGNISIKATTSEKMGFIGREEGIAVFATVLI 156 >UniRef50_C9LKY7 IspD/IspF enzyme n=1 Tax=Dialister invisus DSM 15470 RepID=C9LKY7_9FIRM Length = 392 Score = 229 bits (585), Expect = 2e-59, Method: Composition-based stats. Identities = 72/156 (46%), Positives = 101/156 (64%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R+G G+D+H F P+ +GG++I GL HSD DV +HA+ DALLGAA L DIG Sbjct: 232 IRVGEGYDIHRFEVSRPLFLGGIKIADSGGLSGHSDADVLIHAIMDALLGAAGLPDIGHF 291 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPD+D F GA S ELL++ R I + Y +GN+D T+IA+ PK+ +I M+ ++ L Sbjct: 292 FPDSDVRFDGACSLELLKQVSRHITKQNYLIGNIDSTVIAEKPKISEYIEAMKAIMSAAL 351 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 + +N+KATT EKLG GRG+GIA A +L + Sbjct: 352 NISKNQINIKATTNEKLGDIGRGKGIAALASVILFR 387 >UniRef50_C0QQE6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Hydrogenothermaceae RepID=C0QQE6_PERMH Length = 168 Score = 229 bits (584), Expect = 3e-59, Method: Composition-based stats. Identities = 74/158 (46%), Positives = 98/158 (62%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 RIG GFD+H +IIGGV+IP+EKG AHSDGD+ HALTDALLGA GDIG+LF Sbjct: 4 RIGTGFDIHRLEEGRKLIIGGVQIPFEKGFKAHSDGDIFFHALTDALLGAIGYGDIGQLF 63 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 PD+D ++GADS L+EA R ++ KGY + N+D I+ + PK+LP ++ A L Sbjct: 64 PDSDKKWEGADSSIFLKEASRIVKEKGYEIVNIDCYILLERPKLLPFREKIIENTANILQ 123 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 + + +K + EKLG GR E + V LL K Sbjct: 124 IDKNRIFIKGKSYEKLGEIGRSEAGSAHVVVLLRKKRS 161 >UniRef50_Q0BTD5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Alphaproteobacteria RepID=ISPDF_GRABC Length = 376 Score = 228 bits (583), Expect = 4e-59, Method: Composition-based stats. Identities = 79/154 (51%), Positives = 106/154 (68%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 RIG G+DVHAF +I+ G+ +P+ +GL HSD DV +HAL DA+ GA A GDIG+ F Sbjct: 220 RIGTGYDVHAFETGRKLILCGIEVPHHQGLAGHSDADVGIHALCDAIYGALAEGDIGRHF 279 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 P T+ ++K ADS LR A RI A+G L N D+T+I + PK+ PH P M +AE LG Sbjct: 280 PPTEASWKDADSARFLRHAAERIAARGGFLANADLTLICEKPKITPHAPAMIARLAELLG 339 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 +D ++VKATT+EKLGFTGR EGIA +A +++ Sbjct: 340 VSIDKISVKATTSEKLGFTGREEGIAAQAAVIIM 373 >UniRef50_C5EY67 Bifunctional enzyme ispD/ispF n=2 Tax=Helicobacter RepID=C5EY67_9HELI Length = 386 Score = 228 bits (582), Expect = 5e-59, Method: Composition-based stats. Identities = 75/152 (49%), Positives = 96/152 (63%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 IG+G D+HA II+GG+ IP + L+AHSDGDV LHA++DA+LG GDIG+ FP Sbjct: 224 IGNGSDIHALKSGNGIILGGISIPCDFELIAHSDGDVCLHAISDAILGGIGAGDIGEWFP 283 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 D + A+K ADS LL++ GY + D+TI AQ PK+ P+ M I+E L Sbjct: 284 DNNNAYKNADSALLLKKIVDFSINVGYQITQADITIFAQKPKLSPYKNAMEKRISEILEI 343 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 + VNVKATTTE LGF GRGEGI +A L Sbjct: 344 PLFSVNVKATTTEHLGFIGRGEGIMVQATLAL 375 >UniRef50_D1BMU2 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase n=6 Tax=Bacteria RepID=D1BMU2_VEIPT Length = 391 Score = 227 bits (581), Expect = 8e-59, Method: Composition-based stats. Identities = 67/156 (42%), Positives = 95/156 (60%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MR+G G+D+H P I+GGV+I + G HSD DV +HAL DALLGAA L DIG Sbjct: 233 MRVGFGYDIHQLKAGRPCILGGVQIESDLGPDGHSDADVLIHALMDALLGAAGLRDIGYY 292 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP D +KG S LL + ++ +G N+D+ +I++ PK+ PHI M++ + L Sbjct: 293 FPPEDDQYKGISSMLLLEKVNFLLKERGLQAYNIDIMVISETPKLKPHIDMMKMNLQSIL 352 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 +D +++KATT E LG GR EGIA +AV + + Sbjct: 353 EIPLDRISIKATTNEMLGAIGRREGIAAQAVVSVYE 388 >UniRef50_Q1QM99 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=37 Tax=Alphaproteobacteria RepID=ISPDF_NITHX Length = 403 Score = 227 bits (580), Expect = 1e-58, Method: Composition-based stats. Identities = 79/155 (50%), Positives = 106/155 (68%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G G+DVHAFG +++ GV++P+ +G LAHSDGDV LHAL DA+LGA A GDIG Sbjct: 234 IRTGTGYDVHAFGDGDHVMLCGVKVPHNRGFLAHSDGDVGLHALVDAILGALADGDIGSH 293 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA S + L+ A R+ A+G + N++VT+I + PK+ P MR IAE Sbjct: 294 FPPSDPQWKGAASDKFLKYAVDRVAARGGRIANLEVTMICERPKIGPLRDTMRARIAEIT 353 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 G + + VKATT+E+LGFTGR EGIA A A + Sbjct: 354 GVAISRIAVKATTSERLGFTGREEGIATTASATVR 388 >UniRef50_A9BVX5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Bacteria RepID=A9BVX5_DELAS Length = 162 Score = 227 bits (579), Expect = 1e-58, Method: Composition-based stats. Identities = 89/147 (60%), Positives = 107/147 (72%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 RIG G+DVHA +I+GG+ +P+E GLL HSD DV LHA+TDALLG AALGDIG+ Sbjct: 6 FRIGEGWDVHALVPGRKLILGGIEVPHELGLLGHSDADVLLHAITDALLGGAALGDIGRH 65 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTDP F+GADS LL EA RR++A G +GN+D TIIAQAPK+ PHIP MR IA L Sbjct: 66 FPDTDPEFRGADSLVLLVEAARRVRATGLEIGNIDSTIIAQAPKLAPHIPAMRERIATAL 125 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIA 147 G +D VNVKA T EKLG G+ + + Sbjct: 126 GLALDQVNVKAKTAEKLGPVGQQQAME 152 >UniRef50_B1GYT3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=ISPF_UNCTG Length = 160 Score = 227 bits (579), Expect = 1e-58, Method: Composition-based stats. Identities = 72/159 (45%), Positives = 100/159 (62%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 M IG G+D H +I+GGV+I +GL HSD DV +HAL DALLGAA L DIG Sbjct: 1 MYIGFGYDAHRLKKGRELILGGVKILTSEGLDGHSDADVLIHALMDALLGAAGLNDIGHF 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPD DP +K S LL ++ ++ + +++ NVD+T+I +APK+ P I M+ I+ + Sbjct: 61 FPDMDPKYKNVSSISLLESVYKELKKQNFSVNNVDITVIVEAPKICPFIADMKENISRVI 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 + + +KATT EK+GF GRGEGIA AVA + + K Sbjct: 121 ELKRERIGIKATTNEKMGFVGRGEGIAAVAVASISQEKK 159 >UniRef50_B9JW91 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=6 Tax=Alphaproteobacteria RepID=ISPDF_AGRVS Length = 407 Score = 226 bits (577), Expect = 2e-58, Method: Composition-based stats. Identities = 72/154 (46%), Positives = 99/154 (64%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G+G+DVH + + G+ I +++ L HSD DVALHALTDALL GDIG Sbjct: 247 VRTGNGYDVHQLVPGDGVTLCGIFIAHDQALSGHSDADVALHALTDALLATCGAGDIGDH 306 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP ++GA SR L A ++ G T+ N D+++IA+APK+ PH MR ++E L Sbjct: 307 FPPSDPQWRGAASRIFLEHAANIVRDAGGTIMNADISLIAEAPKIGPHRQIMREKLSEIL 366 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 G ++ +VKATT EK+GF GRGEGIA A A + Sbjct: 367 GIALERCSVKATTNEKIGFVGRGEGIAAIATATV 400 >UniRef50_B8E112 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Dictyoglomus turgidum DSM 6724 RepID=B8E112_DICTD Length = 164 Score = 226 bits (577), Expect = 2e-58, Method: Composition-based stats. Identities = 71/154 (46%), Positives = 102/154 (66%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R+G G+DVH F + +GG++IP++KGL HSDGDV +HA+ DALLGA+AL DIG Sbjct: 9 IRVGLGYDVHPFEEGRELFLGGIKIPFDKGLKGHSDGDVLIHAIADALLGASALPDIGYF 68 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP D + +G S +L + ++ KG + N+D TIIA+ PK++P ++ ++ L Sbjct: 69 FPVDDKSIEGIPSTIILEKVRDLLKEKGVNIINIDCTIIAEEPKIMPFRDKIIKNLSSIL 128 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 D ++VKATT EKLGF G+ EGIA AVAL+ Sbjct: 129 RIPEDCLSVKATTNEKLGFIGKKEGIAVFAVALV 162 >UniRef50_Q7MQW9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Proteobacteria RepID=ISPDF_WOLSU Length = 379 Score = 226 bits (576), Expect = 3e-58, Method: Composition-based stats. Identities = 78/152 (51%), Positives = 98/152 (64%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G GFDVHAF + + GV IP AHSDGDVA+HAL DALLGAA GDIG+ FPD Sbjct: 216 GSGFDVHAFMEGEGLRLAGVNIPAPVTFKAHSDGDVAIHALIDALLGAAGAGDIGEWFPD 275 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCH 123 +D A+KG DS LL+E + I+ G+ L N D+TI+AQAPK+ P+ M + E + Sbjct: 276 SDLAYKGVDSTLLLQEVIKFIRGIGFELINADLTIMAQAPKLSPYKEAMERRLGEVMEVS 335 Query: 124 MDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 ++VKATTTE LGF GR EG+A A +L Sbjct: 336 RQRISVKATTTESLGFVGRKEGVAVSAQVVLK 367 >UniRef50_Q30QG7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=11 Tax=Epsilonproteobacteria RepID=ISPDF_SULDN Length = 386 Score = 225 bits (575), Expect = 3e-58, Method: Composition-based stats. Identities = 82/152 (53%), Positives = 105/152 (69%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G GFDVHAF +G + +GG++I E G LAHSDGDVA+HAL DALLGAA +GDIG +FPD Sbjct: 228 GVGFDVHAFDDKGEMFLGGIKIDSEYGFLAHSDGDVAIHALIDALLGAAGMGDIGMMFPD 287 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCH 123 D +KGADS+ELL +++ G+ + NVD+TI A+ P++ + MR I+ LG Sbjct: 288 NDVKYKGADSKELLGTLVTKLRHFGFVIVNVDITIAAEKPRIGNYKMAMRKKISSILGID 347 Query: 124 MDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 VN+KATTTEKLGF GRGEG+ A A L Sbjct: 348 AQRVNIKATTTEKLGFIGRGEGVGVIANANLK 379 >UniRef50_Q1AU09 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=6 Tax=Bacteria RepID=ISPF_RUBXD Length = 165 Score = 225 bits (575), Expect = 3e-58, Method: Composition-based stats. Identities = 84/159 (52%), Positives = 106/159 (66%), Gaps = 4/159 (2%) Query: 2 RIGHGFDVHAFG---GEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIG 58 R+G G DVHAF +++GGVRIP E+GL HSD DV HA+TDALLGAA L DIG Sbjct: 5 RVGLGVDVHAFADPAEGRQLVLGGVRIPSERGLRGHSDADVLAHAVTDALLGAAGLEDIG 64 Query: 59 KLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAE 118 FPDTD F+ ADS LLREA R + G+ + NVD +I + P++ H +MR +A Sbjct: 65 HYFPDTDERFRDADSIWLLREARRIV-GGGWEVVNVDAVVICERPRIREHREKMRENLAA 123 Query: 119 DLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 LG V+V+ TT+E+LGFTGRGEGIA +AV LL +A Sbjct: 124 ALGVEASRVSVRGTTSERLGFTGRGEGIAAQAVCLLERA 162 >UniRef50_B6DX86 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Guillardia theta RepID=B6DX86_GUITH Length = 225 Score = 225 bits (574), Expect = 4e-58, Method: Composition-based stats. Identities = 76/164 (46%), Positives = 102/164 (62%), Gaps = 5/164 (3%) Query: 1 MRIGHGFDVHAFGG----EGPIIIGGVRIPY-EKGLLAHSDGDVALHALTDALLGAAALG 55 RIGHGFD+H +IGGV++ E G AHSDGDV H++TDA+LGA +L Sbjct: 62 FRIGHGFDIHRLAPLEVAGQGCVIGGVKVENFELGTEAHSDGDVLYHSVTDAILGALSLP 121 Query: 56 DIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVF 115 DIG+L PDTDP +KG DS + L EAW+ + +GY + N+DVT+I + PK+ P +M Sbjct: 122 DIGQLSPDTDPKWKGCDSEKFLAEAWKLMDERGYQVSNLDVTLILERPKVSPIKSRMEDN 181 Query: 116 IAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 ++ L +D VNVKA T EK+ G G +AC AV L+ K K Sbjct: 182 LSRVLKAELDVVNVKARTHEKVDSIGEGRAMACHAVILMEKKAK 225 >UniRef50_Q0APQ6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=10 Tax=Proteobacteria RepID=ISPDF_MARMM Length = 383 Score = 224 bits (571), Expect = 1e-57, Method: Composition-based stats. Identities = 73/151 (48%), Positives = 94/151 (62%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 G G+DVH + + GV I GL+ HSD D LHALTDA+LGAA GDIG+ FP Sbjct: 228 TGQGYDVHRLEPADVMWLCGVEIRAGLGLIGHSDADAGLHALTDAVLGAAGAGDIGQHFP 287 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 +DP +KGA S L A + ++ G L + D+T+IA+ PK+ PH MR +AE G Sbjct: 288 PSDPQWKGAASDAFLLHAIKLLKQVGGELVHADITLIAERPKIGPHRDAMRARVAELTGL 347 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVAL 153 VN+ ATTTEKLGFTGRGEG+A +A+ Sbjct: 348 PEKRVNIAATTTEKLGFTGRGEGLAAQAIVT 378 >UniRef50_C7GYL8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7GYL8_9FIRM Length = 171 Score = 223 bits (570), Expect = 1e-57, Method: Composition-based stats. Identities = 76/156 (48%), Positives = 100/156 (64%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G G+DVH II+GG++IP E + AHSDGDV H++ DA+LGAA LGDIG+ Sbjct: 14 IRTGIGYDVHKLVPGSEIILGGIKIPCEFSIEAHSDGDVLCHSIMDAMLGAAGLGDIGEH 73 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTD KGA S ELL++ +++ G + N+D II + PK+ +M+ IA + Sbjct: 74 FPDTDAKLKGASSMELLKDVNDKLKKAGMKVANIDAIIILEKPKISEMKVKMKENIANVI 133 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 M VN+KATTTEKLG GR EGIA +AV L K Sbjct: 134 EIDMGRVNIKATTTEKLGSIGRSEGIASQAVVTLEK 169 >UniRef50_Q9ZM19 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=14 Tax=Helicobacter RepID=ISPDF_HELPJ Length = 409 Score = 221 bits (564), Expect = 7e-57, Method: Composition-based stats. Identities = 68/157 (43%), Positives = 98/157 (62%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 IG GFD HAF + P+++GGV + E GL AHSDGD LHA+ DA+LGA GDIG+ FP Sbjct: 252 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 311 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 D DP +K A S+ELL+ Q+ G+ L + TI ++ PK+ P+ P + +++ LG Sbjct: 312 DNDPKYKNASSKELLKIVLDFSQSIGFELLEMGATIFSEIPKITPYKPAILENLSQLLGL 371 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 +++KATT EK+GF G+ EG+ +A + K Sbjct: 372 EKSQISLKATTMEKMGFIGKQEGLLVQAHVSMRYKQK 408 >UniRef50_B1I0S9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=9 Tax=Bacteria RepID=ISPDF_DESAP Length = 394 Score = 221 bits (563), Expect = 8e-57, Method: Composition-based stats. Identities = 68/141 (48%), Positives = 94/141 (66%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 +G G+DVH + +I+GGV +P+++GLL HSD DV +HA+ DALLGAA GDIG+ FP Sbjct: 232 VGFGYDVHRLVDDRKLILGGVEVPHDRGLLGHSDADVLVHAVMDALLGAAGAGDIGRWFP 291 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 D DP ++G S +LL ++ +G N+D ++A+AP++ P I +MR +A LG Sbjct: 292 DDDPTYRGISSMDLLVRVAAFLRERGLETSNLDAVVVAEAPRLSPFISRMRDNLASVLGV 351 Query: 123 HMDDVNVKATTTEKLGFTGRG 143 VNVKATTTE LGFTG G Sbjct: 352 SPAAVNVKATTTEGLGFTGSG 372 >UniRef50_A3ZYT9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A3ZYT9_9PLAN Length = 162 Score = 220 bits (561), Expect = 1e-56, Method: Composition-based stats. Identities = 68/157 (43%), Positives = 95/157 (60%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIG G D H GP+ +GGV I +++ L+ HSD DV +HA+TDALLGAA L DIG+ Sbjct: 2 IRIGLGHDTHRLAEGGPLRLGGVDILHDQHLVGHSDADVLMHAITDALLGAANLPDIGEW 61 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP++ +G DS + LR A+ ++ +G+ + N+D I AQ PK+ P+ MR +A L Sbjct: 62 FPNSAAENRGRDSADFLRFAYHKVNEEGWRIINIDTVIFAQEPKLSPYKEAMRTALANIL 121 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 V +KA T E++G GR E I E V LL K Sbjct: 122 TIEPAQVGIKAKTGEQVGLVGRREAIQAECVVLLEKI 158 >UniRef50_D1CCF0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CCF0_THET1 Length = 159 Score = 219 bits (559), Expect = 2e-56, Method: Composition-based stats. Identities = 75/157 (47%), Positives = 99/157 (63%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MR G GFD H F ++IGGV IP+ GL HSD DV HA+ DALLGAA++GDIG L Sbjct: 1 MRSGIGFDAHRFVVGRKLVIGGVAIPHHMGLEGHSDADVLTHAIIDALLGAASMGDIGTL 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 F DP G DS +LL + ++ G+ + +VD TIIAQAP+M P+I MR I++ + Sbjct: 61 FSSDDPDLAGVDSTKLLAKVCEYVRGAGWDIDHVDSTIIAQAPRMSPYIGAMRDKISKVM 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 + V++KATTT+ LG GR EGIA AV + + Sbjct: 121 EIPLTSVSIKATTTDGLGPWGREEGIAALAVCNISRK 157 >UniRef50_Q2GER2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Neorickettsia RepID=ISPF_NEOSM Length = 168 Score = 219 bits (558), Expect = 4e-56, Method: Composition-based stats. Identities = 74/165 (44%), Positives = 98/165 (59%), Gaps = 8/165 (4%) Query: 2 RIGHGFDVHAFGG-----EGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAA---A 53 R+G G+DVH I++ GV +P E ++AHSDGDVALHAL DALLGAA Sbjct: 3 RVGFGYDVHKIDKPVKTGNTCIVLCGVSVPCEYKVIAHSDGDVALHALVDALLGAACIEG 62 Query: 54 LGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMR 113 DIG LFPDTD ++G S + IQ GY + N D+TI+ + P++ + +M+ Sbjct: 63 ANDIGMLFPDTDEKWRGKSSSYFVEHVVTLIQRAGYVVNNADLTIVCETPRIQQYKSEMQ 122 Query: 114 VFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 +A+ L + +NVKATTTEKLGF GR EGIA A+ L K Sbjct: 123 QQVADLLCVRKEQINVKATTTEKLGFEGRKEGIAAYAIVSLTKIR 167 >UniRef50_C3XI64 Bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Helicobacter bilis ATCC 43879 RepID=C3XI64_9HELI Length = 485 Score = 217 bits (555), Expect = 7e-56, Method: Composition-based stats. Identities = 67/153 (43%), Positives = 95/153 (62%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 IG+G D+H F + + GV+I G AHSDGDVA+HA+ D++LGA GDIG+LFP Sbjct: 328 IGYGSDIHGFIDSKDMYLCGVKIESSMGFKAHSDGDVAIHAIIDSILGAMNYGDIGELFP 387 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 D+ FK DS+ LL+E + + G L N+D+TI AQ P++ P+ QM+ +A L Sbjct: 388 DSKDEFKNIDSKILLKEVYDYCLSVGLELINLDITITAQTPRISPYKAQMQEVLANILYL 447 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 V++KA+T E LGF GR EG+ ++A L Sbjct: 448 PKMCVSIKASTAEGLGFVGRKEGVLVNSIAQLK 480 >UniRef50_Q4FM31 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Candidatus Pelagibacter RepID=ISPDF_PELUB Length = 371 Score = 216 bits (552), Expect = 1e-55, Method: Composition-based stats. Identities = 68/156 (43%), Positives = 94/156 (60%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 ++ G GFDVH + +GGV+IP G L HSDGD LHA+TDA+LGA ++GDIG+ Sbjct: 214 IKFGIGFDVHRLVPNKKLYLGGVKIPSPIGTLGHSDGDPVLHAVTDAILGACSMGDIGEK 273 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 F D + FK S LL E ++ KGY + N+D+ II Q PK+ + Q+ IA+ Sbjct: 274 FSDKNKKFKNIRSTILLSEIIKQTLKKGYLINNLDINIITQKPKIQKYKKQILNCIAKIC 333 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 +N+K TTEKLG G+ + IACE +A +IK Sbjct: 334 NISPTQINIKGKTTEKLGVIGKEKAIACEVIASVIK 369 >UniRef50_Q310X3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Desulfovibrionales RepID=ISPDF_DESDG Length = 399 Score = 216 bits (551), Expect = 2e-55, Method: Composition-based stats. Identities = 74/159 (46%), Positives = 95/159 (59%), Gaps = 2/159 (1%) Query: 3 IGHGFDVHAFG-GEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 +G G+DVH FG P+ +GGV I G++AHSDGDV LHALTDA+LG LGDIG LF Sbjct: 241 VGWGYDVHRFGSDGRPMKLGGVPIAGGPGVIAHSDGDVLLHALTDAVLGCMGLGDIGMLF 300 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 PDTD A+ ADS +L E + + G + +VD+TII Q P++ P Q+ I Sbjct: 301 PDTDAAYDNADSAVMLNEVLEKARNAGLLITHVDLTIITQIPRITPWRDQIHKNICRITR 360 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVAL-LIKATK 159 VN+KATT EKLGFTG +GI A L + + Sbjct: 361 LDASSVNLKATTEEKLGFTGEKKGIKAVAAVTALRRVSS 399 >UniRef50_C6BS25 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase n=2 Tax=Desulfovibrio RepID=C6BS25_DESAD Length = 396 Score = 216 bits (551), Expect = 2e-55, Method: Composition-based stats. Identities = 70/155 (45%), Positives = 95/155 (61%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 +G G+DVH FG P+++GGV IP ++AHSDGDV LHAL DA+LG GDIG FP Sbjct: 241 VGWGYDVHKFGEGRPMVLGGVPIPGGPEVIAHSDGDVLLHALADAILGLFGGGDIGHHFP 300 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 DT A + S +++E + + G + +VD+T+I+Q PK+ PH +R +A +G Sbjct: 301 DTSDACENMSSGIIVKEVMAKAEEAGVEIVHVDLTVISQIPKLSPHRELIRKNVASVMGL 360 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 VNVKATT EKLGFTG +GI A +K Sbjct: 361 DKAQVNVKATTEEKLGFTGEKKGIKAVAAVTGLKK 395 >UniRef50_B0SAT2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=6 Tax=Leptospira RepID=ISPF_LEPBA Length = 162 Score = 214 bits (545), Expect = 9e-55, Method: Composition-based stats. Identities = 62/161 (38%), Positives = 88/161 (54%), Gaps = 2/161 (1%) Query: 1 MRIGHGFDVHAF--GGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIG 58 R+G+G D H P+++ GV I E L HSD DV LHA+ DA+LGA +LGDIG Sbjct: 2 FRVGNGIDFHKLIHEPFRPLVLAGVEIKSEFAFLGHSDADVILHAVADAILGALSLGDIG 61 Query: 59 KLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAE 118 FPDTDP +K S ++ + + K + L NVD T + PK+ P ++ +A Sbjct: 62 VHFPDTDPQYKNMKSTRIIEKCLELVAEKKFKLINVDCTYVGDHPKISPIRAELNASLAN 121 Query: 119 DLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 +D V++KATT+E +G GR EG+ A L+ K Sbjct: 122 ITKLPLDCVSIKATTSEGMGALGRSEGVMVMATVLIESLKK 162 >UniRef50_B8D9J7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=55 Tax=Gammaproteobacteria RepID=ISPF_BUCA5 Length = 161 Score = 214 bits (545), Expect = 9e-55, Method: Composition-based stats. Identities = 84/159 (52%), Positives = 117/159 (73%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIG+GFD+HAFG P+IIGGV IP EKGL+AHS+GD+ +H+L DALLGA A+GDIG Sbjct: 1 MRIGYGFDLHAFGSTKPLIIGGVLIPCEKGLIAHSNGDLLIHSLIDALLGATAMGDIGSF 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP + +K DSR LL++ W +I Y + N+D+TIIA+ PKMLP+I MR ++ DL Sbjct: 61 FPSNNYIYKNIDSRILLKKIWNKIILLNYDICNIDITIIAEYPKMLPYIFFMRSNLSLDL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 +D++++K+TT++K+G GR E IAC ++ +LIK K Sbjct: 121 NTEIDNISIKSTTSKKIGCIGRKEAIACHSIVMLIKNKK 159 >UniRef50_B2URI3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Verrucomicrobia RepID=ISPF_AKKM8 Length = 169 Score = 213 bits (544), Expect = 1e-54, Method: Composition-based stats. Identities = 68/153 (44%), Positives = 96/153 (62%), Gaps = 1/153 (0%) Query: 3 IGHGFDVHAFGG-EGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 G G+D+H F P+++GGV IP +GL HSD DV HA+ DALLGAA L DIG F Sbjct: 8 TGIGYDIHRFAEVPRPLMLGGVHIPSSRGLDGHSDADVLCHAIADALLGAAGLPDIGYWF 67 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 P DP+ K S +++ +A I+ +G + NVD ++IA++P++ P++ QM+ + LG Sbjct: 68 PPGDPSCKDIPSLDIVAKAVSLIRERGGRIVNVDSSLIAESPRISPYLEQMKGALGAALG 127 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 V +KATT E+LG GR EGIA AVA + Sbjct: 128 ISPVRVGIKATTNEQLGALGRREGIAAFAVAAI 160 >UniRef50_Q5P993 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=7 Tax=Anaplasmataceae RepID=ISPF_ANAMM Length = 184 Score = 213 bits (543), Expect = 2e-54, Method: Composition-based stats. Identities = 78/162 (48%), Positives = 105/162 (64%), Gaps = 4/162 (2%) Query: 1 MRIGHGFDVHAFG----GEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGD 56 R+G G+DVH F G I++ GV I + + + AHSDGDV HAL DALLG G Sbjct: 10 FRVGIGYDVHGFADSPPENGHIVLCGVEIAFHRKIKAHSDGDVGTHALVDALLGCVGEGS 69 Query: 57 IGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFI 116 IG+ FP+TDP ++ S L EA + AKGY + N D+TI+ + PK++PH+P+M++F+ Sbjct: 70 IGEHFPNTDPRWENMSSTHFLLEAQSKALAKGYAVLNFDLTIVCELPKIIPHVPKMKLFM 129 Query: 117 AEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 ++ LG +N+KA TTEKLGF GRGEGIA AV L K T Sbjct: 130 SKLLGMDASAINIKAVTTEKLGFIGRGEGIAAHAVVLCRKVT 171 >UniRef50_A5V2U9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=8 Tax=Bacteria RepID=ISPDF_SPHWW Length = 382 Score = 212 bits (540), Expect = 4e-54, Method: Composition-based stats. Identities = 82/154 (53%), Positives = 99/154 (64%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 R GFDVH F + +GGVRI +++ L HSD DVALHALTDALLG A GDIG F Sbjct: 225 RTAMGFDVHGFTAGDGVQLGGVRIAHDRALAGHSDADVALHALTDALLGTIAAGDIGSHF 284 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 P +D +KGADS L A + A G + VD+TII +APK+ PH +R IA LG Sbjct: 285 PPSDQRWKGADSAMFLAHARDLVAAAGGIVDFVDLTIICEAPKVGPHRAAIRDRIAALLG 344 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 V+VKATTTE+LGFTGR EGIA +AVA + Sbjct: 345 LTAGQVSVKATTTERLGFTGRREGIAAQAVATVR 378 >UniRef50_D1B5E2 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B5E2_THEAS Length = 381 Score = 211 bits (539), Expect = 5e-54, Method: Composition-based stats. Identities = 75/156 (48%), Positives = 96/156 (61%), Gaps = 2/156 (1%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPY-EKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 R GHG+DVH P+I+GG+ I GL HSD D HA+ DA+LGAA DIG L Sbjct: 226 RCGHGYDVHPLVPGRPLILGGLEIEGANLGLQGHSDADAVCHAVADAILGAAGEPDIGTL 285 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +D +KGA S +LL EA+RR+ G+ + VDVTI AQ PK+ IP++R I+ L Sbjct: 286 FPASDDRYKGAYSLDLLAEAYRRVVQGGFQIQWVDVTINAQVPKLSSWIPRIRSSISRAL 345 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 G + VNVK + E +G GRGE I C AVA L + Sbjct: 346 G-GLKVVNVKVKSGEHVGSVGRGESIVCHAVATLRR 380 >UniRef50_B9KAZ0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Thermotoga RepID=ISPF_THENN Length = 165 Score = 211 bits (538), Expect = 7e-54, Method: Composition-based stats. Identities = 61/158 (38%), Positives = 89/158 (56%), Gaps = 3/158 (1%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 M IG G+D H +++ GV I G L HSDGDV HA+ DALLGA LGDIG Sbjct: 6 MFIGFGYDRHPLVEGRRLVLAGVEIDAPLGSLGHSDGDVLSHAIIDALLGAGCLGDIGTW 65 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP+T +K A+S +LL+E + ++ +G+++ NVD T++A K+ P+ ++ + L Sbjct: 66 FPET-KEYKDANSLDLLKETVKILEERGFSVVNVDATVVASIVKLSPYREKILENLKSAL 124 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 VNVK + LGF G GI+ AV L+ + Sbjct: 125 ET--SRVNVKFKSGNTLGFEGEERGISAYAVCLVEEKK 160 >UniRef50_B8CD73 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Thalassiosira pseudonana RepID=B8CD73_THAPS Length = 263 Score = 207 bits (529), Expect = 7e-53, Method: Composition-based stats. Identities = 69/183 (37%), Positives = 97/183 (53%), Gaps = 26/183 (14%) Query: 1 MRIGHGFDVHAFGG----EGPIIIGGVRIPYE----------------------KGLLAH 34 +RIGHGFD+H P++IGGV I +E G++AH Sbjct: 74 LRIGHGFDIHRMVPLEEAGQPVVIGGVVIDHEDQKWTDKEGTYTGTPNSIYKTQLGVIAH 133 Query: 35 SDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNV 94 SDGDV H+L DA+ GA L DIG++F DTDP +KG DS + + A+ ++ GY +GNV Sbjct: 134 SDGDVIYHSLVDAIFGALTLPDIGQVFQDTDPRWKGCDSSKFMEHAYEVMKYYGYQIGNV 193 Query: 95 DVTIIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 DVT+I + PK+ P+M+ I L VN+KA T E++ G ++C V L Sbjct: 194 DVTLILERPKVAGFKPRMKENIVRLLHTTDGRVNIKARTHERVDSVGELRSLSCHVVVTL 253 Query: 155 IKA 157 K Sbjct: 254 EKV 256 >UniRef50_C1F762 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F762_ACIC5 Length = 207 Score = 207 bits (529), Expect = 7e-53, Method: Composition-based stats. Identities = 72/159 (45%), Positives = 94/159 (59%), Gaps = 3/159 (1%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +RIG+G+D HAF P+ IGG+ I + +GL HSDGDV LHA+TDALLGA A GDIG Sbjct: 3 IRIGYGWDSHAFKPGVPLRIGGLAIEHPEGLAGHSDGDVLLHAITDALLGAVAAGDIGSF 62 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP DP +KGADS L A IQ GY + NVD T++ AP++ P +MR +A L Sbjct: 63 FPPGDPRWKGADSAIFLNIALEEIQNAGYRIANVDTTLVLAAPRIGPIAGEMRERVASLL 122 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 + D+++KA T E LG A LL + + Sbjct: 123 DIPLGDISIKAKTPEGLGL---DHVAQAHATVLLERVEE 158 >UniRef50_A7HDA2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=5 Tax=Bacteria RepID=ISPDF_ANADF Length = 386 Score = 207 bits (528), Expect = 1e-52, Method: Composition-based stats. Identities = 79/155 (50%), Positives = 101/155 (65%), Gaps = 1/155 (0%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G G+D H F +++GGV + GLL HSD DV HA+ DA+LG A LGD+G+ FPD Sbjct: 233 GVGYDTHRFAEGRRLVLGGVEFEGD-GLLGHSDADVCAHAIGDAILGGAGLGDLGRHFPD 291 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCH 123 TDP +KG S LLRE ++ A G+ +GN DVT+ A+ PK+ P +MR +AE LG Sbjct: 292 TDPRWKGVSSLALLREIAAKVAAAGFRVGNCDVTLAARRPKIAPRAEEMRARLAEALGVT 351 Query: 124 MDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 VNVKATT E +GF GRGEGIA AVALL++ Sbjct: 352 PGQVNVKATTGEGMGFVGRGEGIAAHAVALLVRVR 386 >UniRef50_Q73KC6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Bacteria RepID=ISPF_TREDE Length = 161 Score = 206 bits (526), Expect = 2e-52, Method: Composition-based stats. Identities = 70/154 (45%), Positives = 97/154 (62%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MR G G+D+H +++GGV IP++KG AHSDGDV LHA+TDALLGA +GDIG+ Sbjct: 1 MRTGLGYDLHRLVRGKKLMMGGVHIPFKKGEKAHSDGDVLLHAITDALLGACGMGDIGEF 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +D +K A+S ELL W RI G+ + N+D II + PK+LP ++R IA L Sbjct: 61 FPPSDKKWKDANSSELLSTVWERISEAGWKIQNIDCVIIIEEPKILPFREEIRKSIAGIL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 + + +KA T E +G GRG+ +A A L+ Sbjct: 121 KIEKEQIFIKAKTGEGIGIIGRGKAVAALASCLI 154 >UniRef50_Q2RFM1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=4 Tax=Bacteria RepID=ISPF_MOOTA Length = 163 Score = 206 bits (526), Expect = 2e-52, Method: Composition-based stats. Identities = 91/154 (59%), Positives = 109/154 (70%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIG+G+DVH +++GGV IPY++GL HSD DV LHAL DALLGAAALGDIG Sbjct: 1 MRIGYGYDVHGLVPGRKLVLGGVTIPYDRGLAGHSDADVLLHALADALLGAAALGDIGHY 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP DP +K ADS LLRE +R +Q GY L N D TI AQ P++ P+I MR IA L Sbjct: 61 FPPGDPRYKDADSMLLLREVYRHVQTAGYRLANADATITAQEPRLAPYIDAMRERIAAAL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 G + ++VKATTTE LGFTGRGEGI+ +AV LL Sbjct: 121 GVTKEQISVKATTTEGLGFTGRGEGISAQAVVLL 154 >UniRef50_Q1MR76 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=4 Tax=Desulfovibrionaceae RepID=ISPDF_LAWIP Length = 399 Score = 206 bits (525), Expect = 2e-52, Method: Composition-based stats. Identities = 61/163 (37%), Positives = 91/163 (55%), Gaps = 7/163 (4%) Query: 3 IGHGFDVHAFG-------GEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALG 55 +G+G+DVH + + +GG+ IP ++AHSDGDV LHAL DALLG G Sbjct: 237 VGYGYDVHKYVTEDQINQPIRSMRLGGISIPNAPNVVAHSDGDVLLHALMDALLGCIGGG 296 Query: 56 DIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVF 115 DIG FPD+D + G +S LL ++ + ++D TI+AQ PK+ + +R Sbjct: 297 DIGLHFPDSDKRYDGINSAILLDHVLTKVLESSIKIVHMDATIVAQLPKISQYREAIRSN 356 Query: 116 IAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 ++ L + +VN+KATT E LGFTG +GI + I+ + Sbjct: 357 LSRLLDLDLANVNIKATTEEGLGFTGECKGIKAIVIVTAIRIS 399 >UniRef50_Q1IVA8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Candidatus Koribacter versatilis Ellin345 RepID=ISPF_ACIBL Length = 155 Score = 204 bits (521), Expect = 6e-52, Method: Composition-based stats. Identities = 72/156 (46%), Positives = 93/156 (59%), Gaps = 3/156 (1%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R+G GFD H F P+ IGG+ IP+ GL HSDGDV LHA+TDALLGA A GDIG Sbjct: 2 IRVGLGFDSHEFREGIPLRIGGLTIPHTHGLSGHSDGDVLLHAITDALLGAVAAGDIGAF 61 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP +DP +KGA+S + EA R I+ GY +GNVD +++ APK+ PH ++ +A+ L Sbjct: 62 FPPSDPKWKGANSVVFIEEAMRHIETAGYRVGNVDCSLVLNAPKIGPHAKAIQESVAKLL 121 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 V +KA T E L G V LL K Sbjct: 122 KIEPTAVGIKAKTPEGLNLDG---TALAHVVVLLEK 154 >UniRef50_B2KDX1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase n=1 Tax=Elusimicrobium minutum Pei191 RepID=B2KDX1_ELUMP Length = 382 Score = 202 bits (516), Expect = 2e-51, Method: Composition-based stats. Identities = 56/154 (36%), Positives = 84/154 (54%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 R G GFD+H + IGG+ IP+ KG L HSDGDV LHA+ DA LGA G+IG + Sbjct: 226 RTGIGFDLHRLVEGRKLFIGGLEIPHTKGFLGHSDGDVVLHAVCDAALGAVCAGEIGVYY 285 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 P TD +G S ++ ++ ++ K + ++D II + PKM PH +R + + Sbjct: 286 PPTDAKIEGISSVDIAKKVIEILKEKNARIVHIDAVIITEEPKMKPHYQAIRESLGKVFN 345 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 +D ++ K+ + EKLG G G C+ V + Sbjct: 346 MGVDSISFKSKSHEKLGDIGAGNAAMCQCVVTVK 379 >UniRef50_B1L8F8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=4 Tax=Thermotogaceae RepID=B1L8F8_THESQ Length = 160 Score = 202 bits (515), Expect = 3e-51, Method: Composition-based stats. Identities = 63/158 (39%), Positives = 86/158 (54%), Gaps = 3/158 (1%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 M IG G+D H +I+ GV I G L HSDGDV HA+ DALLGA LGDIG Sbjct: 1 MFIGFGYDRHPLVEGRRLILAGVEIDSPVGSLGHSDGDVLSHAIIDALLGAVGLGDIGTW 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP+T ++GA S ELL++ I+ +G+ + NVD T++ +M + ++ + L Sbjct: 61 FPET-EEYRGAISLELLKKTMGMIEERGFKVINVDSTVVLSGVRMSAYRDRIVENLKSVL 119 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 VNVK + LGF G G GI+ AV LL + Sbjct: 120 KTP--HVNVKFKSGNTLGFEGEGRGISAYAVCLLEEKE 155 >UniRef50_B7FYU1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B7FYU1_PHATR Length = 244 Score = 202 bits (514), Expect = 4e-51, Method: Composition-based stats. Identities = 66/180 (36%), Positives = 93/180 (51%), Gaps = 25/180 (13%) Query: 1 MRIGHGFDVHAFGG----EGPIIIGGVRIPY---------------------EKGLLAHS 35 +RIGHGFD+H P++IGGV I + E G++AHS Sbjct: 62 LRIGHGFDIHRMAPLAEAGQPVVIGGVVIDHLPQKWTDAEGRYVEKGGVYETELGVVAHS 121 Query: 36 DGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVD 95 DGDV H++ DA+ GA L DIG++F DTDP +KG DS + + A + GY +GN+D Sbjct: 122 DGDVIYHSIVDAIFGALTLPDIGQVFQDTDPRWKGCDSSKFMEHAHTVMADYGYKVGNID 181 Query: 96 VTIIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 VT+I + PK+ P M+ I L VN+KA T E++ G ++C V L Sbjct: 182 VTLILERPKVASFKPAMKKNIVNLLQTTPGRVNIKARTHERVDSVGELRSLSCHVVMTLE 241 >UniRef50_A8F4L5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Thermotoga lettingae TMO RepID=A8F4L5_THELT Length = 163 Score = 202 bits (514), Expect = 4e-51, Method: Composition-based stats. Identities = 52/155 (33%), Positives = 83/155 (53%), Gaps = 2/155 (1%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R+G G D H F +I+ GV I GLL HSDGD H+L D+LLGA LGDIG+ Sbjct: 4 LRVGIGTDRHPFVEGRKLILAGVEINSSVGLLGHSDGDALCHSLIDSLLGAVCLGDIGQY 63 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP+TD +K A S LL + I+ +G+ + N+D + ++ + M +++ + Sbjct: 64 FPETD-EWKDASSIFLLEKIIDMIRDQGWEVVNIDTIVTCGRIRLSDYRDDMIKNLSKIM 122 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 ++VK + LGF + +G++ + LL Sbjct: 123 NIPEQRISVKFKSANGLGFESQ-DGVSVLTICLLR 156 >UniRef50_B1Q2Q5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Perkinsus marinus RepID=B1Q2Q5_9ALVE Length = 237 Score = 201 bits (512), Expect = 7e-51, Method: Composition-based stats. Identities = 65/164 (39%), Positives = 100/164 (60%), Gaps = 6/164 (3%) Query: 1 MRIGHGFDVHAF----GGEGPIIIGGVRIP--YEKGLLAHSDGDVALHALTDALLGAAAL 54 +RIGH +D+H F GP I+ GV +P + GL+AHSDGDV H++TDA+LG+ L Sbjct: 74 LRIGHAWDIHRFGRRSAENGPFILAGVEVPDCSDIGLVAHSDGDVIFHSVTDAILGSIGL 133 Query: 55 GDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRV 114 DIG+ +PDTDP ++G S + L + +R A G+ + ++DVT++ + PK+ +P + Sbjct: 134 RDIGQYYPDTDPEWEGQSSDKFLHDTLKRASALGFRVISIDVTLVLERPKVGKVMPAVVE 193 Query: 115 FIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 + + + + VNVKA T+EKL G G+ + AV LL K Sbjct: 194 NLRKAINDNRASVNVKARTSEKLNAAGEGKSVEAHAVVLLYKDR 237 >UniRef50_Q4MZY9 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Theileria RepID=Q4MZY9_THEPA Length = 210 Score = 200 bits (510), Expect = 1e-50, Method: Composition-based stats. Identities = 72/161 (44%), Positives = 97/161 (60%), Gaps = 6/161 (3%) Query: 2 RIGHGFDVHAF----GGEGPIIIGGVRIPYE-KGLLAHSDGDVALHALTDALLGAAALGD 56 R+G G+D+H G +I+GGV +P + +LAHSDGDV LH+++DA+LGA GD Sbjct: 51 RVGFGYDIHRVVNAGEGGKTLILGGVEVPGDSVRVLAHSDGDVVLHSISDAVLGALGKGD 110 Query: 57 IGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFI 116 IG FPDT+P F+ +S ++LR + GY+L NVD II + PK+ P Q++ + Sbjct: 111 IGDYFPDTNPQFEDYNSVKILRRVLEIAEEMGYSLVNVDACIILEYPKLGPVKSQIKENL 170 Query: 117 AEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 LG H VNVKA T EKL G+G IAC AV LL Sbjct: 171 QSLLG-HGTVVNVKAKTNEKLDSIGKGSAIACHAVVLLQNI 210 >UniRef50_C4XSW4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=7 Tax=Desulfovibrionales RepID=ISPDF_DESMR Length = 400 Score = 199 bits (508), Expect = 2e-50, Method: Composition-based stats. Identities = 75/162 (46%), Positives = 99/162 (61%), Gaps = 8/162 (4%) Query: 3 IGHGFDVHAFG--------GEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAAL 54 G+G+DVH + P+ +GG I +LAHSDGDV LHALTDA+LG A Sbjct: 237 TGYGYDVHRYADPRNPGKQPPRPMKLGGFPILGAPEVLAHSDGDVLLHALTDAVLGCVAG 296 Query: 55 GDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRV 114 GDIG+LFPD++P F S L EA +AKG T+ +VD+TIIAQ PK+ PH +R+ Sbjct: 297 GDIGRLFPDSNPDFDNMASGVFLSEALLAAKAKGLTITHVDLTIIAQIPKISPHAEAIRL 356 Query: 115 FIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 +A LG + + VN+KATT E LGFTG +GI A+ + Sbjct: 357 NVAALLGLNKEQVNLKATTEEGLGFTGEKKGIKAVALVSGWR 398 >UniRef50_C4RE02 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (Fragment) n=1 Tax=Micromonospora sp. ATCC 39149 RepID=C4RE02_9ACTO Length = 220 Score = 199 bits (507), Expect = 2e-50, Method: Composition-based stats. Identities = 67/153 (43%), Positives = 89/153 (58%), Gaps = 3/153 (1%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 R+ G DVHAF P + G+ P + GL HSD DV HA +ALL AA LGD+G F Sbjct: 65 RVAIGTDVHAFEVGRPCWLAGLLWPGQDGLAGHSDADVVAHAACNALLSAAGLGDLGSNF 124 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 +P + GA LL E RR++A G+ +GNV V ++ PK+ P + ++E +G Sbjct: 125 GVAEPEWAGAPGVALLAETARRVRAAGFEIGNVSVQVVGNRPKIGPRRAEAEAVLSEAVG 184 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 V V A TT+ LGFTGRGEG+A AVAL+ Sbjct: 185 AP---VAVSAATTDGLGFTGRGEGLAGIAVALV 214 >UniRef50_Q72HP8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=5 Tax=Deinococci RepID=ISPF_THET2 Length = 152 Score = 195 bits (497), Expect = 3e-49, Method: Composition-based stats. Identities = 66/154 (42%), Positives = 85/154 (55%), Gaps = 4/154 (2%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIG+G D H P+ + G+ IP G LAHSDGD ALHALTDALL A LGDIG L Sbjct: 1 MRIGYGEDSHRLEEGRPLYLCGLLIPSPVGALAHSDGDAALHALTDALLSAYGLGDIGLL 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDTDP ++G S LREA R ++A+G L + + PK+ PH + +A L Sbjct: 61 FPDTDPRWRGERSEVFLREALRLVEARGARLLQASLVLTLDRPKLGPHRKALVDSLARLL 120 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 D + + T+E L + + AV LL Sbjct: 121 RLPQDRIGLTFKTSEGLAPS----HVQARAVVLL 150 >UniRef50_C8R0Y1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase n=1 Tax=Desulfurivibrio alkaliphilus AHT2 RepID=C8R0Y1_9DELT Length = 454 Score = 192 bits (490), Expect = 2e-48, Method: Composition-based stats. Identities = 60/133 (45%), Positives = 83/133 (62%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 RIGHG+DVH + P+I+GGV I + GLL HSD DV HAL DA+LGA GDIG+ F Sbjct: 235 RIGHGYDVHRLVTDRPLILGGVTIEHHLGLLGHSDADVLTHALCDAILGALGAGDIGRHF 294 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 PD D ++G S +LL + ++ A L + D+TIIA+ PK+ P + M+ +A Sbjct: 295 PDNDQQYRGISSLKLLAQVMTKVWAANCRLHHADLTIIAEKPKLAPQLAAMQANLAAACQ 354 Query: 122 CHMDDVNVKATTT 134 + +N+KATTT Sbjct: 355 VNPSQINLKATTT 367 >UniRef50_D0RP30 Bifunctional enzyme IspD/ispF n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RP30_9RICK Length = 400 Score = 190 bits (485), Expect = 9e-48, Method: Composition-based stats. Identities = 57/154 (37%), Positives = 94/154 (61%), Gaps = 1/154 (0%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G G+D+H + IGG++IP + G + HSDGD LHAL D+ +GAA LGDIG LFP Sbjct: 248 GIGYDIHKMSPGYNLYIGGIKIPSKYGAVGHSDGDSLLHALIDSFMGAARLGDIGTLFP- 306 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCH 123 + +KG S +L+RE +++ + ++D+ II Q+P + + +++ I++ Sbjct: 307 NNKKYKGIRSTKLVREIIIKLKMINLKISSIDLNIILQSPNLKNYKEKIKKNISKLCFIK 366 Query: 124 MDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 + +N+KA TT+KLG G+ + +ACE ++ L A Sbjct: 367 PNKINIKAKTTDKLGIIGKNKALACEVISTLENA 400 >UniRef50_B3L0R0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=4 Tax=Plasmodium RepID=B3L0R0_PLAKH Length = 272 Score = 189 bits (482), Expect = 2e-47, Method: Composition-based stats. Identities = 64/177 (36%), Positives = 89/177 (50%), Gaps = 19/177 (10%) Query: 1 MRIGHGFDVHAFGGEGP------------------IIIGGVRIPYEKGLLAHSDGDVALH 42 +RIG G+D+H P + IGGV++ +L+HSDGDV H Sbjct: 94 VRIGQGYDIHQIRVSTPEDITVDSSADANKQNFKRLTIGGVQVD-TISVLSHSDGDVIYH 152 Query: 43 ALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQA 102 AL DALLG D+G LFPD +K S LR A + K Y + N+D+ +IA+ Sbjct: 153 ALVDALLGGMNCLDLGTLFPDGSEKYKNKKSISFLRYARLLLYKKNYAIANLDIIVIAEI 212 Query: 103 PKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 PK+ P ++ I+ LG V++K T EKLG G+ + I C A ALLI+ Sbjct: 213 PKISPIREEIVRNISSALGISESQVSLKGKTHEKLGPIGQKKAIECFANALLIRKKS 269 >UniRef50_A5CTY4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=28 Tax=Actinobacteria (class) RepID=ISPDF_CLAM3 Length = 410 Score = 188 bits (479), Expect = 4e-47, Method: Composition-based stats. Identities = 64/156 (41%), Positives = 87/156 (55%), Gaps = 3/156 (1%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G G DVHA P+ + G+ P E GL HSDGD HA+ DALL AA LGDIG + Sbjct: 257 LRSGIGTDVHAVDASQPLWLAGLHWPGEAGLAGHSDGDAVSHAMCDALLSAAGLGDIGGI 316 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 F DP GA LR ++ GY + NV V ++A PK+ P + ++ + Sbjct: 317 FGTDDPELDGAHGEVFLRRTAELVRDAGYRIVNVAVQVMAVRPKLSPRRAEAERILSAAV 376 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 G V++ TTT+ LGFTGRG+G+A A AL+ + Sbjct: 377 GAP---VSLAGTTTDGLGFTGRGDGVAAVATALVER 409 >UniRef50_C1TMK1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TMK1_9BACT Length = 357 Score = 187 bits (476), Expect = 9e-47, Method: Composition-based stats. Identities = 59/158 (37%), Positives = 91/158 (57%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G GFDVH +++GGV +P GL HSD D+ H ++DA+LGAA L DIG++ Sbjct: 190 VRTGIGFDVHPLVPGRSLVLGGVEVPSPMGLDGHSDADIICHGISDAILGAAGLPDIGRV 249 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP D A+K ADS ELLRE +++ G+++ +DV + AQ P++ + ++ + Sbjct: 250 FPACDDAYKDADSYELLREVVSKVERCGWSIVWLDVVLHAQLPRIGETVIEITKNLDSVW 309 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 M VN+K + E +G G G + C AVA + + Sbjct: 310 NDGMRRVNLKVKSGEGVGSVGSGHCMMCYAVATIKNTS 347 >UniRef50_B4U9N6 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Aquificaceae RepID=ISPF_HYDS0 Length = 156 Score = 186 bits (474), Expect = 2e-46, Method: Composition-based stats. Identities = 54/155 (34%), Positives = 78/155 (50%), Gaps = 3/155 (1%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 RIG G D H F + +GG GL HSDGD LHA+TDA+LGA A DIG LF Sbjct: 3 RIGIGQDAHYFEKGKKLYLGGEEFDIGYGLKGHSDGDALLHAITDAILGALAKTDIGTLF 62 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 PD K +S + L +A + Y++ N+D IIA P + ++ ++ L Sbjct: 63 PDKSKENKNRNSVDFLNKALEIMYDMDYSIVNLDCNIIADKPNISSVRDKIIESLSRLLS 122 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 D++++KA T E + + + +ALL K Sbjct: 123 IPKDNISIKAKTKEGYN---KEDSLEVVCIALLQK 154 >UniRef50_B1VS88 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=93 Tax=Actinomycetales RepID=ISPF_STRGG Length = 172 Score = 185 bits (472), Expect = 3e-46, Method: Composition-based stats. Identities = 61/157 (38%), Positives = 88/157 (56%), Gaps = 4/157 (2%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYE-KGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 +G G D+HAF + G++ E GL HSD DV HA +AL AA LGD+G+ F Sbjct: 19 VGIGTDIHAFEEGRKLWCAGLKWEGEGPGLAGHSDADVVAHAACNALFSAAGLGDLGQHF 78 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 P + GA LL EA R ++A G+ +GNV V ++ PK+ + + ++E +G Sbjct: 79 GTGRPEWSGAAGITLLTEAARIVRAGGFEIGNVAVQVVGSRPKIGKRREEAQKVLSEAVG 138 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 V++ A T++ LGFTGRGEGIA A AL+ + Sbjct: 139 AP---VSLSAATSDGLGFTGRGEGIAGLATALVYRTA 172 >UniRef50_Q1QBM3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=16 Tax=Bacteria RepID=ISPF_PSYCK Length = 168 Score = 184 bits (469), Expect = 7e-46, Method: Composition-based stats. Identities = 89/158 (56%), Positives = 108/158 (68%), Gaps = 4/158 (2%) Query: 1 MRIGHGFDVHAFGGEGP----IIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGD 56 ++IG G DVHAF G +++ GV I + LLAHSDGDV LHAL DALLGA ALGD Sbjct: 4 IKIGQGIDVHAFHNNGQQQQYVVLAGVPIDHTHSLLAHSDGDVVLHALADALLGALALGD 63 Query: 57 IGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFI 116 IG+ FPDTD A G DSR LLR + ++ A GY LGN D+T++ + PK+ PH MR I Sbjct: 64 IGQHFPDTDAANAGLDSRVLLRYVYGKVLAAGYILGNADITVMCERPKLAPHNLAMRANI 123 Query: 117 AEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 A DL + +++VKATTTEKLGFTGR EGI AV LL Sbjct: 124 ASDLQTDVSNISVKATTTEKLGFTGRQEGIMANAVVLL 161 >UniRef50_P62368 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Plasmodium RepID=ISPF_PLAF7 Length = 240 Score = 184 bits (468), Expect = 8e-46, Method: Composition-based stats. Identities = 62/174 (35%), Positives = 85/174 (48%), Gaps = 20/174 (11%) Query: 1 MRIGHGFDVHAFG-------------------GEGPIIIGGVRIPYEKGLLAHSDGDVAL 41 +RIG G+D+H + +GGV+I +L+HSDGD+ Sbjct: 64 IRIGQGYDIHKIKVLDEEYNTYANNDFNKNEQSFKTLTLGGVKINNVL-VLSHSDGDIIY 122 Query: 42 HALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQ 101 H++ D++LGA DIG LFPD D K +S LR A I K Y +GNVD+ +IAQ Sbjct: 123 HSIVDSILGALGSLDIGTLFPDKDEKNKNKNSAIFLRYARLLIYKKNYDIGNVDINVIAQ 182 Query: 102 APKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 PK+ + I+ L ++VK T EKLG G + I C A LLI Sbjct: 183 VPKISNIRKNIIKNISTVLNIDESQISVKGKTHEKLGVIGEKKAIECFANILLI 236 >UniRef50_B6KAQ3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Toxoplasma gondii RepID=B6KAQ3_TOXGO Length = 338 Score = 183 bits (466), Expect = 1e-45, Method: Composition-based stats. Identities = 60/138 (43%), Positives = 84/138 (60%), Gaps = 3/138 (2%) Query: 25 IPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRI 84 + G++AHSDGDV LHA+ DA+ GA ALGDIG+ F D++PAF+G S L+ A + Sbjct: 176 VENSFGVVAHSDGDVLLHAVCDAVFGAFALGDIGEHFSDSNPAFRGMSSSLLVARALEIV 235 Query: 85 QAK--GYTLGNVDVTIIAQAPKML-PHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTG 141 +AK + LG+VD T++ A K +MR +AE L V+VKA T+E +G G Sbjct: 236 RAKHPDWRLGSVDATVVFDAMKFGRARKQKMRENLAELLQLPAAAVSVKAKTSEGVGPVG 295 Query: 142 RGEGIACEAVALLIKATK 159 R E +AC V L K+T+ Sbjct: 296 RKEAVACHVVLTLFKSTR 313 Score = 41.1 bits (96), Expect = 0.013, Method: Composition-based stats. Identities = 18/37 (48%), Positives = 22/37 (59%), Gaps = 7/37 (18%) Query: 1 MRIGHGFDVHA-----FGGEGPIIIGGVRI--PYEKG 30 RIGHG+D+H GP++IGGV I P EKG Sbjct: 36 FRIGHGYDLHRVTANPLEATGPLVIGGVCISTPPEKG 72 >UniRef50_B1VIQ0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=10 Tax=Actinomycetales RepID=ISPF_CORU7 Length = 162 Score = 183 bits (466), Expect = 2e-45, Method: Composition-based stats. Identities = 58/156 (37%), Positives = 80/156 (51%), Gaps = 3/156 (1%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 R+G D H P + G+ G HSDGDV H + DALL A+ LGD+G Sbjct: 8 RVGIASDAHQVEPGKPCWMAGLLFEDADGCEGHSDGDVVSHVIVDALLSASGLGDLGSFV 67 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 + G L+ E + + G+T+GNV +I PKM P + + E +G Sbjct: 68 GVGRKEYDGVSGERLITECRQLLAENGFTIGNVAAQMIGNRPKMGPRREEAERRLTELVG 127 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 V+V ATTT+K+GFTGRGEG+A A A++ KA Sbjct: 128 AP---VSVSATTTDKMGFTGRGEGVAALATAVVWKA 160 >UniRef50_B9RCH5 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Ricinus communis RepID=B9RCH5_RICCO Length = 230 Score = 179 bits (455), Expect = 3e-44, Method: Composition-based stats. Identities = 51/117 (43%), Positives = 70/117 (59%) Query: 38 DVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVT 97 DV LH + DA+LGA L DIG++FPD+DP +KGA S ++EA R + GY +GN+D T Sbjct: 71 DVLLHCVVDAILGALGLPDIGQIFPDSDPKWKGAPSSVFIKEAVRLMHEAGYDIGNLDAT 130 Query: 98 IIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALL 154 +I Q PK+ PH +R + E LG +N+KA T EK+ G IA V + Sbjct: 131 LILQRPKLSPHKEAIRSNLCELLGADPSVINLKAKTHEKVDSLGENRSIAAHTVMNV 187 >UniRef50_C1CZ33 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Deinococci RepID=C1CZ33_DEIDV Length = 167 Score = 178 bits (453), Expect = 4e-44, Method: Composition-based stats. Identities = 61/158 (38%), Positives = 84/158 (53%), Gaps = 5/158 (3%) Query: 2 RIGHGFDVHAFGGEGPIIIGGVRIPY-EKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 RIG+G D H P+I+GGV IP+ E+G +AHSDGD LHA+ DALL ALGDIG Sbjct: 13 RIGYGEDAHRLARGLPLILGGVPIPHAEQGAVAHSDGDAVLHAVADALLSGLALGDIGHY 72 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FPDT +K DSR +L A ++A+GY NV + + PK+ P ++ +A L Sbjct: 73 FPDTAAEYKEMDSRIILDRALMLVRARGYAPVNVALVVTLDRPKLGPLRAEIAQTVAGLL 132 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 +V V T+E L + + LL + Sbjct: 133 DLPATEVGVSFKTSEGLAP----DHVQTRVTVLLGRTR 166 >UniRef50_C9M692 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase n=2 Tax=Synergistaceae RepID=C9M692_9BACT Length = 384 Score = 176 bits (448), Expect = 2e-43, Method: Composition-based stats. Identities = 50/142 (35%), Positives = 79/142 (55%), Gaps = 2/142 (1%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +R G G+DVH + P+++ GV +P GL HSD D+ H DA+L AA L DIG L Sbjct: 221 IRTGIGYDVHPLTPDRPLVLAGVTVPSPLGLAGHSDADIISHVAADAVLSAAGLPDIGTL 280 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 +P +D + G S +LL +A R + G+++ V + + AQ PK+ P+ P +R + + L Sbjct: 281 YPSSDEQYAGCRSMDLLADAVSRAEQAGWSVQFVSLVVTAQVPKLAPYGPAIRQALEKVL 340 Query: 121 GCHMDDVNVKATTTEKLGFTGR 142 G ++V + E +G G Sbjct: 341 GD--GKISVTFKSGESVGPVGE 360 >UniRef50_Q14PQ0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Spiroplasma citri RepID=Q14PQ0_SPICI Length = 152 Score = 173 bits (440), Expect = 2e-42, Method: Composition-based stats. Identities = 48/156 (30%), Positives = 86/156 (55%), Gaps = 7/156 (4%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MR+G+ +D+H +GG+ IP + + A SDGD+ LH +++A++GA LGD+G+ Sbjct: 1 MRVGNSYDLHNLKMGTGFYLGGILIPCQYQVEAVSDGDILLHTISEAIIGALGLGDLGEW 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 F +T+ +S+ +L++A + + Y + N+D TII P++ H ++ + + L Sbjct: 61 FDETNKK---INSQLILKKALTLMAEQNYQISNIDTTIIIDEPRLQKHKKAIKTNLQKLL 117 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 + +N+KATTTE+ I LL+K Sbjct: 118 QISAEKINLKATTTEQNFP----NIIQSYTTLLLLK 149 >UniRef50_A9BHL8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Petrotoga mobilis SJ95 RepID=ISPF_PETMO Length = 162 Score = 173 bits (439), Expect = 2e-42, Method: Composition-based stats. Identities = 54/156 (34%), Positives = 81/156 (51%), Gaps = 4/156 (2%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYE--KGLLAHSDGDVALHALTDALLGAAALGDIG 58 ++IG G+DVH F +I+GGV I + GLL HSDGDV HAL D+LLG LG IG Sbjct: 2 LKIGFGYDVHPFAENRRLILGGVVINHPKGYGLLGHSDGDVFFHALIDSLLGMCGLGSIG 61 Query: 59 KLFPDTDPAFKGADSRELLREAWRRIQAKG-YTLGNVDVTIIAQAPKMLPHIPQMRVFIA 117 + FP++ F+ S LL + I + + N+DV II+++ + Q++ + Sbjct: 62 EYFPES-KEFENISSSILLEKTIDLINKRYIVKINNIDVVIISKSVNISSITGQIKNNTS 120 Query: 118 EDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVAL 153 L + +N+K + LG G +GI L Sbjct: 121 CILNLEVSRINLKGKSGNGLGVGGNDQGIEVYCTIL 156 >UniRef50_C7M1Q8 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7M1Q8_ACIFD Length = 364 Score = 172 bits (436), Expect = 4e-42, Method: Composition-based stats. Identities = 69/157 (43%), Positives = 93/157 (59%), Gaps = 6/157 (3%) Query: 1 MRIGHGFDVHAF--GGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIG 58 +R+G G D H P+++GGV +P GL AHSDGD HA+ DA+LGAA +G IG Sbjct: 205 VRVGLGLDQHPRSDEPGRPLVLGGVTVPGP-GLRAHSDGDALCHAVADAMLGAAGIGGIG 263 Query: 59 KLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAE 118 L+ DTDPAF+GADS ELL R ++ +G + VD TI+ + PK+ P++ +M I Sbjct: 264 DLYADTDPAFRGADSLELLAGCVRLVRGRGLRVVQVDATIVCETPKLSPYLARMARTIEG 323 Query: 119 DLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 + VKA E +G GRGEG+A AV LL Sbjct: 324 VVAAPA---LVKAKHPEGIGALGRGEGVAALAVVLLE 357 >UniRef50_A6LJL2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Thermosipho melanesiensis BI429 RepID=A6LJL2_THEM4 Length = 331 Score = 167 bits (425), Expect = 8e-41, Method: Composition-based stats. Identities = 46/154 (29%), Positives = 75/154 (48%), Gaps = 5/154 (3%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G G+D H E +++GGV I GL HSDGDV +H++ D+LLG + DIG LFP+ Sbjct: 183 GVGWDTHKIIKERKLVLGGVEIDSTFGLKGHSDGDVVIHSIIDSLLGVSLKKDIGVLFPE 242 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCH 123 + +G S +L+E + I KGY N+D +I ++ ++ + + + C Sbjct: 243 SKVP-EGISSVYMLQEVVKAINRKGYFPENIDCVVITDF-RLGSFRDEITKSLEKLVKCP 300 Query: 124 MDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 V++K T + I V+ +I Sbjct: 301 ---VSLKFKTGNGVYPEKNLNAITAICVSNIISI 331 >UniRef50_C5CGG7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=ISPF_KOSOT Length = 156 Score = 167 bits (425), Expect = 9e-41, Method: Composition-based stats. Identities = 55/157 (35%), Positives = 81/157 (51%), Gaps = 6/157 (3%) Query: 2 RIGHGFDVHAFGGEGP-IIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 R+G GFD H + +GGV++ E + HSDGD +HA+ DA+LGA G+IG Sbjct: 3 RVGIGFDAHPLEANKKGLYLGGVKVSEEYSSIGHSDGDALIHAIVDAILGATNAGNIGIW 62 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 FP+ +G S E L ++I A Y + N+D II +M PHI +R+ +A L Sbjct: 63 FPEN-EENRGRRSTEFLEIIRKKILAGKYEILNIDSVIIIDKVRMNPHIENIRLKLARIL 121 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 G ++NVK + L G ++ AV +L K Sbjct: 122 GISKGNINVKPKSGNTLY----GNSVSVYAVCMLKKV 154 >UniRef50_A7HN63 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Fervidobacterium nodosum Rt17-B1 RepID=A7HN63_FERNB Length = 326 Score = 167 bits (425), Expect = 9e-41, Method: Composition-based stats. Identities = 44/155 (28%), Positives = 75/155 (48%), Gaps = 5/155 (3%) Query: 3 IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 G G+D H ++IGGV I GLL HSD DV HA+ D+++G DIG LFP Sbjct: 177 TGIGWDTHPLVESRNLVIGGVDIESNMGLLGHSDADVLTHAIIDSIVGITHKKDIGVLFP 236 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 + + K S ++L E + + + G+ ++D II+ K+ + ++ + L C Sbjct: 237 EN-ESNKDRRSIDMLEEVTKYVISSGFFPSSIDCVIISPI-KLKDYREKITQNLENILNC 294 Query: 123 HMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 V+VK + + + +GI ++ + K Sbjct: 295 ---QVSVKFKSGNNVYPESQNKGITAICISNIDKI 326 >UniRef50_B0BC71 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=18 Tax=Bacteria RepID=ISPF_CHLTB Length = 178 Score = 165 bits (420), Expect = 3e-40, Method: Composition-based stats. Identities = 52/161 (32%), Positives = 81/161 (50%), Gaps = 4/161 (2%) Query: 2 RIGHGFDVHAFGGE---GPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIG 58 R+G G D H F + P I+GG+ G A+SDGDV HA+ +A G +G Sbjct: 18 RVGIGQDSHRFLPDEDPKPCILGGIIFENTPGFEANSDGDVVFHAICNAFSSVTHKGILG 77 Query: 59 KLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAE 118 L + DS L+EA ++ + ++ +TI + PK+LP +P MR IAE Sbjct: 78 GLADELLKTKGITDSVVYLQEAIASLKPT-QRVSHLAITIEGKRPKLLPQLPSMRKRIAE 136 Query: 119 DLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK 159 L +D +N+ AT+ E L G+G G+ C V +++ + Sbjct: 137 VLHIPLDSINITATSGEGLTAMGQGYGVQCFCVLTIMEYCR 177 >UniRef50_B7IFV0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Thermosipho africanus TCF52B RepID=B7IFV0_THEAB Length = 332 Score = 163 bits (415), Expect = 1e-39, Method: Composition-based stats. Identities = 40/154 (25%), Positives = 75/154 (48%), Gaps = 5/154 (3%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPD 63 G G+D H + +I+GGV I + GL HSD DV +H++ D+ +G + DIG+LFP+ Sbjct: 184 GIGWDTHPIKKDRKLILGGVEIESDIGLDGHSDADVLIHSIVDSFVGVSLKKDIGELFPE 243 Query: 64 TDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCH 123 D KG S +L + ++ G+ +VD +I ++ + ++ + + + C Sbjct: 244 KDVP-KGISSVFILENVLKSMKENGFFPESVDCVLITDF-RLGKYRAEISKNLEKIINCP 301 Query: 124 MDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 V++K T + + + V+ +I Sbjct: 302 ---VSIKFKTGNNVYPETNLKAMTAMCVSNIISI 332 >UniRef50_B8I5R3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=6 Tax=Bacteria RepID=B8I5R3_CLOCE Length = 168 Score = 162 bits (410), Expect = 5e-39, Method: Composition-based stats. Identities = 52/156 (33%), Positives = 77/156 (49%), Gaps = 5/156 (3%) Query: 1 MRIGHGFDVHAF---GGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDI 57 M++G G D H F I+GGV L +SD DV LHALT+A+ G + + Sbjct: 13 MKVGIGQDSHRFDFQNNSKKFILGGVIFDDVTPLDGNSDADVVLHALTNAISGVTCVNIL 72 Query: 58 GKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIA 117 GK+ + DS E LREA + + + +V ++I PK+ P I +MR I+ Sbjct: 73 GKVSDEMCLERGITDSSEYLREALKYLVD--VKVVHVSISIECSYPKISPKIAEMRKSIS 130 Query: 118 EDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVAL 153 E LG + V + ATT E L G+G+G+ + Sbjct: 131 ELLGIPENCVGITATTGEGLTAFGQGKGVQAFCIVT 166 >UniRef50_Q83NK3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Tropheryma whipplei RepID=ISPDF_TROW8 Length = 422 Score = 161 bits (408), Expect = 7e-39, Method: Composition-based stats. Identities = 53/154 (34%), Positives = 77/154 (50%), Gaps = 3/154 (1%) Query: 3 IGHGFDVHAFG-GEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLF 61 IG G D H F E P+ + + + L HSDGDV HA T ALL AA +GDIG +F Sbjct: 269 IGVGIDFHKFILDESPLFLACLEWKNYRRLQGHSDGDVVAHACTTALLSAANMGDIGSVF 328 Query: 62 PDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLG 121 A K A L R + G+ + N+ V +I+ P++ + I++ L Sbjct: 329 GVDLAATKDASGAYFLESTNRLLATNGFCVLNIAVQVISNTPRLADRRVEAEHAISDCL- 387 Query: 122 CHMDDVNVKATTTEKLGFTGRGEGIACEAVALLI 155 +++ + TT+ +GF GRGEGI AVA + Sbjct: 388 -SGARISLSSVTTDGMGFLGRGEGIGAIAVAQIY 420 >UniRef50_Q7NC56 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Mycoplasma gallisepticum RepID=ISPF_MYCGA Length = 157 Score = 154 bits (391), Expect = 7e-37, Method: Composition-based stats. Identities = 56/160 (35%), Positives = 87/160 (54%), Gaps = 9/160 (5%) Query: 1 MRIGHGFDVHAFG--GEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIG 58 +RIG GFD H + +GG+ + ++ L+A+SDGDV LHAL+DA+LG + GDIG Sbjct: 5 IRIGQGFDSHKLKTKKNSRVFLGGIPVRTDQQLIANSDGDVVLHALSDAVLGCGSFGDIG 64 Query: 59 KLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAE 118 F + D + KG DS+ +L + I+ N+D+TI AQ ++ P +++ + + Sbjct: 65 MYFDENDLSNKGLDSKTILNYCLKLIKKLKLEFVNIDLTIFAQDIRIDPIRFEIKSSLMK 124 Query: 119 DLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 GC + VNVKA + E+ IAC V L+ Sbjct: 125 LTGC--NSVNVKAKSYEE-----PKNEIACSCVVLMNTNK 157 >UniRef50_Q8EUA4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Mycoplasma penetrans RepID=Q8EUA4_MYCPE Length = 165 Score = 154 bits (390), Expect = 1e-36, Method: Composition-based stats. Identities = 48/156 (30%), Positives = 81/156 (51%), Gaps = 8/156 (5%) Query: 2 RIGHGFDVHAFGGEG-PIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 +IG+G D+H E + G+ + ++AHSDGD+ LH+++ A+LGA +L D+G Sbjct: 17 KIGNGIDIHKIKKEKCKQRLAGLDFELDYKIIAHSDGDIILHSISSAILGALSLQDLGTY 76 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 F DTD K DS E+L ++ + Y++ NVD+TII + Q++ + + L Sbjct: 77 FSDTDSKNKNLDSLEILSMCLNELKKQDYSISNVDITIICEYIIFKDIKDQIKSNLEKLL 136 Query: 121 GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 ++++KAT E+ I V L+ K Sbjct: 137 N--NTEISLKATRYEE-----DKNMIQVNTVLLINK 165 >UniRef50_A7AVQ2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Babesia bovis RepID=A7AVQ2_BABBO Length = 199 Score = 143 bits (363), Expect = 1e-33, Method: Composition-based stats. Identities = 61/162 (37%), Positives = 87/162 (53%), Gaps = 7/162 (4%) Query: 2 RIGHGFDVHAFGG----EGPIIIGGVRIPYEK-GLLAHSDGDVALHALTDALLGAAALGD 56 RIG G+D+H G P +GGV + K ++ HSDGD LHAL DALLGA GD Sbjct: 39 RIGLGYDIHRLVGTGKGGKPFKLGGVLVDDSKIFVVGHSDGDTLLHALADALLGATGCGD 98 Query: 57 IGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPH-IPQMRVF 115 IG F + D K DSR +L A + +GY N+D+ II + ++ ++ Sbjct: 99 IGDYFSELDSINKDMDSRIILESAIKEASLRGYRPTNIDINIILERVRLGRRLKDAIKKA 158 Query: 116 IAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 + + LG + +NVKA T E L GRGE ++C+ +A L + Sbjct: 159 LYDMLGSDV-MINVKAKTNEGLDAIGRGEAVSCQVIAHLKRI 199 >UniRef50_B5Y8V5 Bifunctional enzyme IspD/ispF n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5Y8V5_COPPD Length = 362 Score = 142 bits (358), Expect = 5e-33, Method: Composition-based stats. Identities = 46/158 (29%), Positives = 79/158 (50%), Gaps = 8/158 (5%) Query: 4 GHGFDVHAFGGEGPIIIGGVRIPY-EKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62 G G+D H F P+I+GGVRI + GL + +DGDV +HA+ DALL GD+G L+P Sbjct: 211 GIGWDFHRFSENAPLILGGVRIEDADVGLESWTDGDVIIHAVADALLSTLGQGDLGTLYP 270 Query: 63 DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122 ++ +KG S ++L + R++ K L V ++A P + I + ++ L Sbjct: 271 NSQL-WKGGSSTDILADVMERMRKKHVLLEKATVLLLADKPMLKHWIDPITRNLSSLLNA 329 Query: 123 HMDDVNVKATTTEKLGFTGRG-EGIACEAVALLIKATK 159 V + T +E + G+ G+ + ++ + Sbjct: 330 P---VYLSVTRSEGI--IGKDLNGMISLSFVNCVEVKR 362 >UniRef50_C5BMS2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Teredinibacter turnerae T7901 RepID=C5BMS2_TERTT Length = 157 Score = 138 bits (348), Expect = 6e-32, Method: Composition-based stats. Identities = 44/130 (33%), Positives = 68/130 (52%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIGHG +++GGV + GL +DGD+ L A+ DAL GAA LG+ L Sbjct: 1 MRIGHGIVCAQRTQARKLVLGGVYLEPGFGLAIMNDGDLLLAAVGDALAGAAGLGNFVSL 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL 120 + T P FK A +R LL+ +++KG N+D+++ + + M+ IA+ L Sbjct: 61 YDLTSPDFKHASTRSLLQMLATSLRSKGLRTVNLDISLCGRDLIFNAYRDDMQASIADAL 120 Query: 121 GCHMDDVNVK 130 G +N+K Sbjct: 121 GIDATRINLK 130 >UniRef50_UPI0001913A58 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=2 Tax=Salmonella enterica subsp. enterica serovar Typhi RepID=UPI0001913A58 Length = 128 Score = 137 bits (346), Expect = 1e-31, Method: Composition-based stats. Identities = 85/87 (97%), Positives = 86/87 (98%) Query: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL Sbjct: 1 MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL 60 Query: 61 FPDTDPAFKGADSRELLREAWRRIQAK 87 FPDTDPAFKGADSRELLREAWRRIQ + Sbjct: 61 FPDTDPAFKGADSRELLREAWRRIQPR 87 >UniRef50_C2BUI0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=3 Tax=Mobiluncus RepID=C2BUI0_9ACTO Length = 195 Score = 125 bits (314), Expect = 6e-28, Method: Composition-based stats. Identities = 63/161 (39%), Positives = 86/161 (53%), Gaps = 8/161 (4%) Query: 1 MRIGHGFDVHAFGGE-----GPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALG 55 R+G GFD H F P+ +G + P L HSDGDVA HALTDALL AA LG Sbjct: 37 FRVGQGFDAHRFAAGAPVVGRPLRVGTLSFPDHAPLEGHSDGDVAAHALTDALLAAAGLG 96 Query: 56 DIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVF 115 D+G F + P + GA LR A R + G+ + N VT++ Q P++ H + Sbjct: 97 DLGTNFGVSRPEYAGASGEVFLRAAMRMLHETGWVVVNASVTVVGQEPRLGSHYAEAEAA 156 Query: 116 IAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 + L V+ ATTT+++GFTG EG+A A+ LL + Sbjct: 157 LGNILAAP---VSFSATTTDRMGFTGNKEGLAALAICLLRR 194 >UniRef50_B7GT04 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=14 Tax=Bifidobacterium RepID=ISPF_BIFLI Length = 174 Score = 121 bits (304), Expect = 9e-27, Method: Composition-based stats. Identities = 67/170 (39%), Positives = 85/170 (50%), Gaps = 18/170 (10%) Query: 3 IGHGFDVHAFGG---EGPIIIGGVRIPYEK-----------GLLAHSDGDVALHALTDAL 48 IG GFD H F + I G+ P G+ SDGDVA HAL DAL Sbjct: 8 IGQGFDAHRFAPAGSGRELWIAGLYWPVPDSCSEADAARYEGIEGDSDGDVAAHALIDAL 67 Query: 49 LGAAALGDIGKLFPDT-DPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLP 107 L AA LGDIG LF D G ++L+E + + GYT + V II PK+ Sbjct: 68 LAAARLGDIGSLFGVGADAHGAGRHGIDMLQEVVAHLASNGYTPASASVAIIGNRPKIGT 127 Query: 108 HIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKA 157 + ++ +GC V+V ATTT+ +GFTGRGEGIA A AL+ K Sbjct: 128 RRAEAEAALSAAVGCP---VSVTATTTDHMGFTGRGEGIAAIANALVEKI 174 >UniRef50_Q0PH58 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (Fragment) n=1 Tax=Toxoplasma gondii RepID=Q0PH58_TOXGO Length = 91 Score = 115 bits (289), Expect = 5e-25, Method: Composition-based stats. Identities = 43/91 (47%), Positives = 58/91 (63%), Gaps = 3/91 (3%) Query: 33 AHSDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAK--GYT 90 AHSDGDV LHA+ DA+ GA ALGDIG+ F D++PAF+G S L+ A ++AK + Sbjct: 1 AHSDGDVLLHAVCDAVFGAFALGDIGEHFSDSNPAFRGMSSSILVARALEIVRAKHPDWR 60 Query: 91 LGNVDVTIIAQAPKML-PHIPQMRVFIAEDL 120 LG+VD T++ A K +MR +AE L Sbjct: 61 LGSVDATVVFDAMKFGRARKQKMRENLAELL 91 >UniRef50_Q49436 Uncharacterized protein MG459 n=2 Tax=Mycoplasma RepID=Y459_MYCGE Length = 169 Score = 114 bits (286), Expect = 1e-24, Method: Composition-based stats. Identities = 46/172 (26%), Positives = 71/172 (41%), Gaps = 21/172 (12%) Query: 1 MRIGHGFD-VH---AFGGEGPIIIGGVRIPYEKGL--LAHSD--GDVALHALTDALLGAA 52 +R+G G H + +GGV K + L +SD DV A+ DAL GA Sbjct: 3 LRVGLGSKKYHIKLRKESKNKFWLGGVDFENSKYIYDLENSDEVSDVIQLAVADALFGAT 62 Query: 53 ALGD--IGKLFPDTDPAFKGADSRE---LLREAWRRIQAKGYTLGNVDVTI-IAQAPKML 106 ALGD I + FKG +E +L + I+ K + + N+D+++ I Q K+ Sbjct: 63 ALGDGHIVFNKGKSTVQFKGTAKKEAPRVLARTYNFIR-KNWIINNIDISLEIPQEQKVD 121 Query: 107 PHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAT 158 + + FI L +N+K I C AV L+ + Sbjct: 122 DYKHAIFAFICSALRISELTINLKVRKP------LDSNEINCLAVVLVERQK 167 >UniRef50_Q0PH60 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (Fragment) n=1 Tax=Eimeria tenella RepID=Q0PH60_EIMTE Length = 87 Score = 98.1 bits (244), Expect = 7e-20, Method: Composition-based stats. Identities = 35/86 (40%), Positives = 47/86 (54%) Query: 57 IGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFI 116 IG+ FPDT KG +SRE + A A GYT+ VDVT++ Q P++ QM + Sbjct: 2 IGQPFPDTAAENKGRNSREFVAAAVAAAAAAGYTVAQVDVTLMLQRPRISSKKQQMIDTL 61 Query: 117 AEDLGCHMDDVNVKATTTEKLGFTGR 142 A LG V++KA T E +G GR Sbjct: 62 AAALGISSSKVSLKAKTGEGVGPVGR 87 >UniRef50_UPI0001B44793 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n=1 Tax=Listeria monocytogenes FSL J1-208 RepID=UPI0001B44793 Length = 62 Score = 81.6 bits (201), Expect = 8e-15, Method: Composition-based stats. Identities = 31/59 (52%), Positives = 42/59 (71%) Query: 98 IIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIK 156 ++ ++ KM P++ Q+++ IAE L VNVKATTTEKLGFTGR EGIA A+ L+ K Sbjct: 4 LLLKSQKMAPYVEQIKLRIAELLHADSAQVNVKATTTEKLGFTGREEGIASLAIVLIEK 62 >UniRef50_UPI0001699D05 tRNA pseudouridine synthase D n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2' RepID=UPI0001699D05 Length = 101 Score = 48.4 bits (115), Expect = 7e-05, Method: Composition-based stats. Identities = 16/30 (53%), Positives = 23/30 (76%) Query: 112 MRVFIAEDLGCHMDDVNVKATTTEKLGFTG 141 MR +A DL ++ ++VKATTTE++GFTG Sbjct: 1 MRAHLANDLKIDVNQISVKATTTERMGFTG 30 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.315 0.186 0.609 Lambda K H 0.267 0.0567 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 1,418,233,544 Number of Sequences: 3077464 Number of extensions: 83912226 Number of successful extensions: 162681 Number of sequences better than 1.0e-01: 122 Number of HSP's better than 0.1 without gapping: 360 Number of HSP's successfully gapped in prelim test: 3 Number of HSP's that attempted gapping in prelim test: 162075 Number of HSP's gapped (non-prelim): 373 length of query: 159 length of database: 1,040,396,356 effective HSP length: 118 effective length of query: 41 effective length of database: 677,255,604 effective search space: 27767479764 effective search space used: 27767479764 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 88 (38.0 bits)