BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (288 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_A7MT09 Methenyltetrahydrofolate cyclohydrolase n=64 Tax... 438 e-122 UniRef50_A5F6V4 Methenyltetrahydrofolate cyclohydrolase n=270 Ta... 429 e-119 UniRef50_Q0AB42 Methenyltetrahydrofolate cyclohydrolase n=19 Tax... 350 3e-95 UniRef50_Q057D7 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=... 317 2e-85 UniRef50_A0LE04 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 303 4e-81 UniRef50_B2V9R3 Methenyltetrahydrofolate cyclohydrolase n=14 Tax... 303 5e-81 UniRef50_A3DEE6 Methenyltetrahydrofolate cyclohydrolase n=6 Tax=... 291 2e-77 UniRef50_B5YJV1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 284 3e-75 UniRef50_A0M554 Methenyltetrahydrofolate cyclohydrolase n=88 Tax... 275 9e-73 UniRef50_Q11UD1 Methenyltetrahydrofolate cyclohydrolase n=6 Tax=... 274 3e-72 UniRef50_A5VAA8 Methenyltetrahydrofolate cyclohydrolase n=107 Ta... 272 1e-71 UniRef50_A4XY05 Methenyltetrahydrofolate cyclohydrolase n=47 Tax... 271 2e-71 UniRef50_Q17W13 Methenyltetrahydrofolate cyclohydrolase n=14 Tax... 270 6e-71 UniRef50_B8HXS0 Methenyltetrahydrofolate cyclohydrolase n=25 Tax... 268 1e-70 UniRef50_A0K8R4 Methenyltetrahydrofolate cyclohydrolase n=254 Ta... 268 1e-70 UniRef50_Q6F9E6 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 265 1e-69 UniRef50_D0GMJ6 Bifunctional protein FolD n=2 Tax=Leptotrichia R... 265 2e-69 UniRef50_Q18GK1 Methenyltetrahydrofolate cyclohydrolase n=15 Tax... 262 1e-68 UniRef50_A8JH65 5,10-methylenetetrahydrofolate dehydrogenase n=4... 261 2e-68 UniRef50_Q46A53 Methenyltetrahydrofolate cyclohydrolase n=13 Tax... 261 2e-68 UniRef50_Q9X7F6 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 261 2e-68 UniRef50_Q2JQ25 Methenyltetrahydrofolate cyclohydrolase n=8 Tax=... 261 3e-68 UniRef50_C5R8B8 Bifunctional protein: methylenetetrahydrofolate ... 260 3e-68 UniRef50_A9HEL1 Methenyltetrahydrofolate cyclohydrolase n=82 Tax... 260 4e-68 UniRef50_Q8LEA3 5,10-methylenetetrahydrofolate dehydrogenase:5,1... 260 5e-68 UniRef50_Q6GI21 Methenyltetrahydrofolate cyclohydrolase n=83 Tax... 259 5e-68 UniRef50_Q12V26 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=... 258 2e-67 UniRef50_O65271 F6N23.26 protein n=34 Tax=Viridiplantae RepID=O6... 257 3e-67 UniRef50_Q82XC3 Methenyltetrahydrofolate cyclohydrolase n=7 Tax=... 256 4e-67 UniRef50_D2QZP8 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 254 2e-66 UniRef50_UPI0001BC5140 bifunctional protein FolD n=3 Tax=Fusobac... 254 2e-66 UniRef50_B0KLM9 Methenyltetrahydrofolate cyclohydrolase n=184 Ta... 254 2e-66 UniRef50_Q1II76 Methenyltetrahydrofolate cyclohydrolase n=15 Tax... 253 4e-66 UniRef50_C8P269 Methylenetetrahydrofolate dehydrogenase/methenyl... 250 4e-65 UniRef50_C7TD85 5,10-methylene-tetrahydrofolate dehydrogenase/me... 249 6e-65 UniRef50_Q03RR1 Methenyltetrahydrofolate cyclohydrolase n=22 Tax... 249 7e-65 UniRef50_C8W0Y6 Methylenetetrahydrofolate dehydrogenase (NADP(+)... 248 2e-64 UniRef50_C4FUB1 Putative uncharacterized protein n=1 Tax=Catonel... 246 7e-64 UniRef50_Q14NV1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 245 1e-63 UniRef50_Q8DMU0 Methenyltetrahydrofolate cyclohydrolase n=80 Tax... 245 1e-63 UniRef50_D0J906 Putative methenyltetrahydrofolate cyclohydrolase... 244 2e-63 UniRef50_C2E8X3 Methylenetetrahydrofolate dehydrogenase (NADP+)/... 244 2e-63 UniRef50_A2BX55 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=... 243 5e-63 UniRef50_A9A4N5 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=... 243 5e-63 UniRef50_B3ESU1 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 243 8e-63 UniRef50_Q049N0 Methenyltetrahydrofolate cyclohydrolase n=18 Tax... 242 1e-62 UniRef50_C8PLX3 Bifunctional protein FolD n=1 Tax=Treponema vinc... 242 1e-62 UniRef50_Q8RAD0 Methenyltetrahydrofolate cyclohydrolase n=11 Tax... 242 1e-62 UniRef50_UPI00016C0DE6 Methenyltetrahydrofolate cyclohydrolase n... 241 2e-62 UniRef50_D1AX33 Methylenetetrahydrofolate dehydrogenase (NADP(+)... 241 3e-62 UniRef50_A8ZTQ4 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=... 240 4e-62 UniRef50_P13995 Methenyltetrahydrofolate cyclohydrolase n=52 Tax... 239 6e-62 UniRef50_B1GZ24 Bifunctional protein FolD n=2 Tax=Bacteria RepID... 239 7e-62 UniRef50_C3K8G7 Putative histidine biosynthesis-related tetrahyd... 238 1e-61 UniRef50_B2S3X1 Methenyltetrahydrofolate cyclohydrolase n=35 Tax... 238 2e-61 UniRef50_Q1QD30 Methenyltetrahydrofolate cyclohydrolase n=50 Tax... 237 3e-61 UniRef50_Q2SRE7 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=... 237 4e-61 UniRef50_B0TFC9 Methenyltetrahydrofolate cyclohydrolase n=7 Tax=... 235 2e-60 UniRef50_C8P9U1 Putative uncharacterized protein folD2 n=1 Tax=L... 233 5e-60 UniRef50_A6LU44 Methenyltetrahydrofolate cyclohydrolase n=22 Tax... 233 7e-60 UniRef50_B8C1N0 5, 10-methylenetetrahydrofolate dehydrogenase n=... 231 2e-59 UniRef50_Q9H903 Methenyltetrahydrofolate cyclohydrolase n=75 Tax... 230 5e-59 UniRef50_B0S8U6 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=... 230 5e-59 UniRef50_A8GNK0 Methenyltetrahydrofolate cyclohydrolase n=15 Tax... 229 7e-59 UniRef50_A5V1H2 Methenyltetrahydrofolate cyclohydrolase n=7 Tax=... 228 2e-58 UniRef50_D0MY89 Bifunctional folD protein n=1 Tax=Phytophthora i... 228 2e-58 UniRef50_C0R292 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=... 225 1e-57 UniRef50_A8IFV5 5,10-methylenetetrahydrofolate dehydrogenase (Fr... 224 2e-57 UniRef50_Q2GLF2 Methenyltetrahydrofolate cyclohydrolase n=41 Tax... 223 7e-57 UniRef50_P11586 Formyltetrahydrofolate synthetase n=378 Tax=root... 221 3e-56 UniRef50_D0N1V3 Bifunctional folD protein n=1 Tax=Phytophthora i... 220 5e-56 UniRef50_D0N1T3 Bifunctional folD protein n=1 Tax=Phytophthora i... 220 6e-56 UniRef50_UPI0000DB7ABF PREDICTED: similar to Bifunctional methyl... 218 2e-55 UniRef50_B1ZYH0 Methenyltetrahydrofolate cyclohydrolase n=8 Tax=... 217 3e-55 UniRef50_Q7TU81 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 217 3e-55 UniRef50_C5BI30 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=... 217 4e-55 UniRef50_C8PD95 Putative uncharacterized protein folD n=1 Tax=La... 212 1e-53 UniRef50_D1ITY4 Whole genome shotgun sequence of line PN40024, s... 212 1e-53 UniRef50_C9LM47 Methylenetetrahydrofolate dehydrogenase/methenyl... 211 3e-53 UniRef50_D1CB15 Methylenetetrahydrofolate dehydrogenase (NADP(+)... 208 2e-52 UniRef50_Q254F7 Methenyltetrahydrofolate cyclohydrolase n=13 Tax... 207 3e-52 UniRef50_UPI00015B59A5 PREDICTED: similar to ENSANGP00000016878 ... 207 5e-52 UniRef50_O65269 F6N23.28 protein n=1 Tax=Arabidopsis thaliana Re... 202 1e-50 UniRef50_A9UXQ1 Predicted protein n=7 Tax=cellular organisms Rep... 201 2e-50 UniRef50_C1XHV3 5,10-methylenetetrahydrofolate dehydrogenase (NA... 200 4e-50 UniRef50_B5IEC2 Tetrahydrofolate dehydrogenase/cyclohydrolase, N... 200 5e-50 UniRef50_A8SN78 Putative uncharacterized protein n=1 Tax=Parvimo... 200 5e-50 UniRef50_D2W298 Predicted protein n=2 Tax=Naegleria gruberi RepI... 200 6e-50 UniRef50_UPI00006CCCC6 methylenetetrahydrofolate dehydrogenase n... 200 6e-50 UniRef50_A0DMT9 Chromosome undetermined scaffold_57, whole genom... 199 8e-50 UniRef50_C5C958 Methenyltetrahydrofolate cyclohydrolase n=118 Ta... 199 1e-49 UniRef50_Q83FS2 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 198 2e-49 UniRef50_C1FDF4 5,10-methylene-tetrahydrofolate dehydrogenase/cy... 196 1e-48 UniRef50_Q0AWX5 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 195 2e-48 UniRef50_A5CF58 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 194 4e-48 UniRef50_UPI00017F08E4 PREDICTED: similar to MGC137793 protein n... 191 3e-47 UniRef50_B7QFP4 C1-tetrahydrofolate synthase, putative n=1 Tax=I... 190 4e-47 UniRef50_Q0S375 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=... 190 5e-47 UniRef50_A9NE96 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 189 8e-47 UniRef50_C0GE27 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 189 9e-47 UniRef50_C8WXG8 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 188 2e-46 UniRef50_Q21285 Dauer or aging adult overexpression protein 3, c... 188 2e-46 UniRef50_Q04FB7 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=... 187 5e-46 UniRef50_Q4T2B9 Chromosome undetermined SCAF10300, whole genome ... 186 8e-46 UniRef50_A5N5B5 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=... 184 3e-45 UniRef50_B0VGJ7 FolD bifunctional protein n=1 Tax=Candidatus Clo... 182 1e-44 UniRef50_C1BVL5 Bifunctional methylenetetrahydrofolate dehydroge... 181 4e-44 UniRef50_C4FZX7 Putative uncharacterized protein n=1 Tax=Abiotro... 181 4e-44 UniRef50_D2RNA3 Methylenetetrahydrofolate dehydrogenase (NADP(+)... 179 9e-44 UniRef50_Q54VK0 Methenyl tetrahydrofolate cyclohydrolase / NADP-... 179 1e-43 UniRef50_A0C3Q0 Chromosome undetermined scaffold_147, whole geno... 179 1e-43 UniRef50_Q189R8 Methenyltetrahydrofolate cyclohydrolase n=26 Tax... 179 1e-43 UniRef50_C1MLD7 5,10-methylene-tetrahydrofolate dehydrogenase/cy... 178 1e-43 UniRef50_B2KB67 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 178 2e-43 UniRef50_B5YA73 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 178 2e-43 UniRef50_D1C3C2 Methylenetetrahydrofolate dehydrogenase (NADP(+)... 177 3e-43 UniRef50_Q0SFQ8 Methenyltetrahydrofolate cyclohydrolase n=11 Tax... 175 1e-42 UniRef50_UPI00006CB712 tetrahydrofolate dehydrogenase/cyclohydro... 175 1e-42 UniRef50_D1BP88 Tetrahydrofolate dehydrogenase/cyclohydrolase n=... 172 9e-42 UniRef50_A4X776 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=... 172 2e-41 UniRef50_A8RJW5 Putative uncharacterized protein n=2 Tax=Clostri... 170 5e-41 UniRef50_C4XED5 Putative uncharacterized protein n=1 Tax=Mycopla... 169 8e-41 UniRef50_C6LCK2 Methylenetetrahydrofolate dehydrogenase/methenyl... 169 9e-41 UniRef50_Q4RT28 Chromosome 12 SCAF14999, whole genome shotgun se... 168 2e-40 UniRef50_C4Z3I2 Methylenetetrahydrofolate dehydrogenase (NADP+) ... 167 3e-40 UniRef50_C7N2I9 Methenyltetrahydrofolate cyclohydrolase /5,10-me... 167 3e-40 UniRef50_UPI00003BDED9 hypothetical protein DEHA0E19294g n=2 Tax... 166 7e-40 UniRef50_C6CV64 Methylenetetrahydrofolate dehydrogenase (NADP(+)... 166 1e-39 UniRef50_Q8EV80 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 165 1e-39 UniRef50_Q1AVQ0 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 165 2e-39 UniRef50_B7AQ13 Putative uncharacterized protein n=3 Tax=Bacteri... 164 3e-39 UniRef50_B5Y9D1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 164 4e-39 UniRef50_Q2JCX4 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=... 163 6e-39 UniRef50_B5RQK8 Methylenetetrahydrofolate dehydrogenase n=2 Tax=... 163 7e-39 UniRef50_C7MLE6 Methenyltetrahydrofolate cyclohydrolase /5,10-me... 162 1e-38 UniRef50_Q979W3 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 162 1e-38 UniRef50_Q6KID0 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 161 2e-38 UniRef50_UPI00003C8447 methylenetetrahydrofolate dehydrogenase/m... 161 3e-38 UniRef50_Q6L046 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 161 3e-38 UniRef50_A7AXK7 Putative uncharacterized protein n=1 Tax=Ruminoc... 160 5e-38 UniRef50_Q5IWX9 Plastid 5,10-methylene-tetrahydrofolate dehydrog... 160 6e-38 UniRef50_B9KZ23 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 159 8e-38 UniRef50_D1J7X9 Methylenetetrahydrofolate dehydrogenase n=1 Tax=... 159 1e-37 UniRef50_B3PMJ8 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 159 1e-37 UniRef50_C2L112 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 159 1e-37 UniRef50_C8WAB5 Tetrahydrofolate dehydrogenase/cyclohydrolase n=... 158 2e-37 UniRef50_B9K850 Bifunctional protein folD n=1 Tax=Thermotoga nea... 157 4e-37 UniRef50_C4QA37 Formate-tetrahydrofolate ligase, putative n=1 Ta... 157 6e-37 UniRef50_C8WUM8 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 156 6e-37 UniRef50_A6LP88 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 156 9e-37 UniRef50_Q86F84 Clone ZZD1003 mRNA sequence n=2 Tax=Schistosoma ... 155 2e-36 UniRef50_A5ILJ9 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=... 155 2e-36 UniRef50_A7HMQ2 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 152 1e-35 UniRef50_UPI000194D930 PREDICTED: methylene tetrahydrofolate deh... 151 2e-35 UniRef50_D1VQM8 Methylenetetrahydrofolate dehydrogenase (NADP(+)... 151 2e-35 UniRef50_Q160C0 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=... 150 4e-35 UniRef50_A6BAZ7 Fold bifunctional protein (Ppdc) (Fragment) n=1 ... 150 6e-35 UniRef50_A5IXS7 FolD bifunctional protein(Methylenetetrahydrofol... 149 1e-34 UniRef50_B7J0W5 Methenyltetrahydrofolate cyclohydrolase n=22 Tax... 147 5e-34 UniRef50_D1B5M7 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 147 6e-34 UniRef50_Q4DH06 Methylenetetrahydrofolate dehydrogenase-like pro... 146 7e-34 UniRef50_A1RQQ5 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=... 146 9e-34 UniRef50_Q4A6B1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 141 3e-32 UniRef50_D1VRZ1 Bifunctional protein FolD n=1 Tax=Peptoniphilus ... 138 3e-31 UniRef50_B8ZZU9 Putative uncharacterized protein MTHFD2 n=2 Tax=... 137 4e-31 UniRef50_Q1J118 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=... 136 9e-31 UniRef50_P47259 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 134 3e-30 UniRef50_A8IQS8 Methylenetetrahydrofolate dehydrogenase/ methyle... 130 5e-29 UniRef50_C5CI88 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 130 7e-29 UniRef50_C8WN84 Tetrahydrofolate dehydrogenase/cyclohydrolase n=... 129 1e-28 UniRef50_Q0AZF5 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 128 2e-28 UniRef50_A9BIV9 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=... 127 4e-28 UniRef50_B9CK25 Bifunctional protein FolD n=1 Tax=Atopobium rima... 127 6e-28 UniRef50_UPI00016B2244 FolD bifunctional protein n=2 Tax=candida... 122 1e-26 UniRef50_Q98QV3 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 122 2e-26 UniRef50_Q7NAE4 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 116 9e-25 UniRef50_Q9XYB0 PugilistDominant (Fragment) n=2 Tax=Eukaryota Re... 115 2e-24 UniRef50_UPI0001B58450 methylenetetrahydrofolate dehydrogenase/m... 109 1e-22 UniRef50_C7GZF5 FolD protein n=1 Tax=Eubacterium saphenum ATCC 4... 108 2e-22 UniRef50_C7HUG7 Bifunctional protein FolD protein n=1 Tax=Anaero... 107 6e-22 UniRef50_B0RZW6 Methylenetetrahydrofolate dehydrogenase n=2 Tax=... 100 8e-20 UniRef50_B6WAQ3 Putative uncharacterized protein n=1 Tax=Anaeroc... 97 9e-19 UniRef50_C7RD94 Tetrahydrofolate dehydrogenase/cyclohydrolase n=... 95 2e-18 UniRef50_B5GAQ6 Tetrahydrofolate dehydrogenase/cyclohydrolase n=... 91 6e-17 UniRef50_Q02046 Methylenetetrahydrofolate dehydrogenase [NAD+] n... 90 9e-17 UniRef50_B3QMF3 Tetrahydrofolate dehydrogenase/cyclohydrolase n=... 89 2e-16 UniRef50_C0Z3J6 AT2G38660 protein n=2 Tax=Arabidopsis thaliana R... 88 4e-16 UniRef50_B4FJK4 Putative uncharacterized protein n=1 Tax=Zea may... 86 1e-15 UniRef50_D1Z754 Whole genome shotgun sequence assembly, scaffold... 86 1e-15 UniRef50_UPI0001904966 Methenyltetrahydrofolate cyclohydrolase n... 84 6e-15 UniRef50_B6FPJ6 Putative uncharacterized protein n=1 Tax=Clostri... 80 1e-13 UniRef50_UPI00005A5066 PREDICTED: similar to Bifunctional methyl... 76 1e-12 UniRef50_Q6UB35 Monofunctional C1-tetrahydrofolate synthase, mit... 75 3e-12 UniRef50_Q4PBA5 Putative uncharacterized protein n=3 Tax=Basidio... 74 5e-12 UniRef50_UPI000023D48A hypothetical protein FG10624.1 n=1 Tax=Gi... 71 4e-11 UniRef50_A9EVL6 Methylenetetrahydrofolate dehydrogenase (NAD(+))... 71 5e-11 UniRef50_A4HZR2 Methylenetetrahydrofolate dehydrogenase-like pro... 71 5e-11 UniRef50_C4QVL0 NAD-dependent 5,10-methylenetetrahydrafolate deh... 70 1e-10 UniRef50_UPI0000D9A063 PREDICTED: similar to Bifunctional methyl... 66 1e-09 UniRef50_A1ZUI3 Tetrahydrofolate dehydrogenase/cyclohydrolase, N... 66 1e-09 UniRef50_B0CXH2 Predicted protein n=1 Tax=Laccaria bicolor S238N... 66 2e-09 UniRef50_A6QZK7 Putative uncharacterized protein n=1 Tax=Ajellom... 61 4e-08 UniRef50_Q4S6Y9 Chromosome 14 SCAF14723, whole genome shotgun se... 61 5e-08 UniRef50_Q0UVW9 Putative uncharacterized protein n=1 Tax=Phaeosp... 60 7e-08 UniRef50_B8BYF8 Predicted protein n=1 Tax=Thalassiosira pseudona... 60 1e-07 UniRef50_B8NT34 Methylenetetrahydrofolate dehydrogenase, putativ... 59 2e-07 UniRef50_Q86KU6 Methylenetetrahydrofolate dehydrogenase [NAD+] n... 57 6e-07 UniRef50_B1AIX6 Methylenetetrahydrofolate dehydrogenase n=15 Tax... 55 2e-06 UniRef50_Q5KEZ0 Methylenetetrahydrofolate dehydrogenase (NAD+), ... 54 5e-06 UniRef50_A8ZN24 Putative uncharacterized protein n=1 Tax=Acaryoc... 54 5e-06 UniRef50_Q6X5D4 Methylene-THF dehydrogenase (Fragment) n=1 Tax=T... 51 4e-05 UniRef50_B9PLA1 Methylenetetrahydrofolate dehydrogenase, putativ... 51 6e-05 UniRef50_Q5PNN5 Novel protein similar to methylenetetrahydrofola... 47 7e-04 UniRef50_B3L796 Putative uncharacterized protein n=2 Tax=Plasmod... 47 7e-04 UniRef50_UPI00015563B5 PREDICTED: similar to Mthfd2-prov protein... 45 0.003 UniRef50_Q3M1J6 Tetrahydrofolate dehydrogenase/cyclohydrolase n=... 43 0.015 >UniRef50_A7MT09 Methenyltetrahydrofolate cyclohydrolase n=64 Tax=cellular organisms RepID=FOLD_VIBHB Length = 286 Score = 438 bits (1127), Expect = e-122, Method: Compositional matrix adjust. Identities = 208/283 (73%), Positives = 245/283 (86%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A+ IDG I+Q VRSEVA +V+AR+ AGLRAPGLAVVLVG +PASQ+YV SKR+ACEE Sbjct: 1 MTAQNIDGTLISQTVRSEVAARVKARVEAGLRAPGLAVVLVGEDPASQVYVGSKRRACEE 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VGFVS+S+DLP TTSE ELL LID LN D IDGILVQLPLPAGID VLERIHP+KDV Sbjct: 61 VGFVSKSFDLPATTSEEELLALIDELNNDAEIDGILVQLPLPAGIDATHVLERIHPEKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHPYNVGRL QR P+LR CTP+GI+TLL+RYNI+ G +AVV+GASNIVGRPM++ELL Sbjct: 121 DGFHPYNVGRLAQRIPKLRSCTPKGIITLLDRYNIELRGKHAVVVGASNIVGRPMTLELL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 LAGCTTT HRFTK+L HV ADL++VAVGKP FIPG+WIK+GA+V+DVGINRLE+GK+ Sbjct: 181 LAGCTTTTCHRFTKDLEGHVRQADLVVVAVGKPNFIPGEWIKKGAVVVDVGINRLESGKL 240 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 VGDV ++ A + AS+ITPVPGGVGPMTVA+LIENT+ AC ++H Sbjct: 241 VGDVEYDKARENASFITPVPGGVGPMTVASLIENTMLACEQFH 283 >UniRef50_A5F6V4 Methenyltetrahydrofolate cyclohydrolase n=270 Tax=Bacteria RepID=FOLD_VIBC3 Length = 286 Score = 429 bits (1104), Expect = e-119, Method: Compositional matrix adjust. Identities = 202/283 (71%), Positives = 240/283 (84%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A+ IDG I+Q VRSEVA +V+AR+ AGLRAPGLAVVLVG +PASQ+YV SKR+ACEE Sbjct: 1 MTAQNIDGTLISQTVRSEVAARVKARVQAGLRAPGLAVVLVGEDPASQVYVGSKRRACEE 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VGFVS+S+DLP T SE LL L++ LN D IDGILVQLPLPAG+D KVLE IHP+KDV Sbjct: 61 VGFVSKSFDLPATASEEALLSLVEELNNDPQIDGILVQLPLPAGMDTTKVLESIHPEKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHPYNVGRL QR P+LR CTP+GI+TLLERYNI G +AV++GASNIVGRPM++ELL Sbjct: 121 DGFHPYNVGRLAQRIPKLRSCTPKGIITLLERYNIPLRGKHAVIVGASNIVGRPMTLELL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 LAGCTTT HRFT++L H+ AD+L+VAVGKP FIPG WIKEGA+V+DVGINRL+ GK+ Sbjct: 181 LAGCTTTTCHRFTQDLEGHIRQADILVVAVGKPNFIPGAWIKEGAVVVDVGINRLDTGKL 240 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 VGDV ++ A RAS+ITPVPGGVGPMTVA+LIENT+ AC ++H Sbjct: 241 VGDVEYDVARTRASFITPVPGGVGPMTVASLIENTMMACEQFH 283 >UniRef50_Q0AB42 Methenyltetrahydrofolate cyclohydrolase n=19 Tax=cellular organisms RepID=FOLD_ALHEH Length = 286 Score = 350 bits (898), Expect = 3e-95, Method: Compositional matrix adjust. Identities = 169/279 (60%), Positives = 215/279 (77%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M+A+I+DGK IA ++R +V ++V+AR+ G R PGLAVVLVG++PAS +YV KR+ACE+ Sbjct: 1 MSAQILDGKAIAAELREQVRKQVEARVERGGRRPGLAVVLVGADPASTVYVGKKRQACEQ 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G S +++LP T++ ELL L+D LN + IDGILVQLPLP ID V++RIHPDKDV Sbjct: 61 LGMHSSAHELPAETTQDELLALVDELNGRDEIDGILVQLPLPDHIDEQTVIDRIHPDKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP N+GRL R P LRPCTP G++T+L I+ G +AV+IG SNIVGRPM+MELL Sbjct: 121 DGFHPVNMGRLTLRLPGLRPCTPNGVMTMLAHAGIELEGKDAVIIGQSNIVGRPMAMELL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 A CT T+ H T+NL V AD+++ AVG+PGF+PGDWIK GA+VIDVGINRLE+GK+ Sbjct: 181 NARCTITICHSRTRNLADRVRAADIVVAAVGRPGFVPGDWIKPGAVVIDVGINRLESGKL 240 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 GDV F A + A +ITPVPGGVGPMTVATL+ NTL A Sbjct: 241 TGDVDFAAARELAGWITPVPGGVGPMTVATLMANTLAAA 279 >UniRef50_Q057D7 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=Gammaproteobacteria RepID=FOLD_BUCCC Length = 284 Score = 317 bits (813), Expect = 2e-85, Method: Compositional matrix adjust. Identities = 151/283 (53%), Positives = 209/283 (73%), Gaps = 3/283 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M KI+DG I++++ ++ +K++ R + PGLA++++G+NPAS IYV KR+AC + Sbjct: 1 METKILDGLKISKKIIKKIKKKIEKRKKKRKKIPGLAMIVIGNNPASLIYVNKKREACNQ 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 GF S + L E EL+ LI LN + IDGIL+QLPLP I+ +K++ I P KDV Sbjct: 61 AGFFSIYWHLSNQIEEIELINLIKKLNKNKCIDGILIQLPLPIKINYLKIITSIDPKKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHPYN+G LCQ P+ R CT +G++TLL++Y I+ GL AV+IG+SNIVG+PM MELL Sbjct: 121 DGFHPYNLGSLCQNNPQFRSCTSKGVITLLKKYKINIHGLYAVIIGSSNIVGKPMYMELL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-- 238 LAGCT T+ ++ TKN++ +V+ ADL+++A+G+P F+ G WIK GAIVID+GIN L N Sbjct: 181 LAGCTVTIVNKNTKNIKTYVKKADLVVIAIGQPNFLYGHWIKLGAIVIDIGINYLYNKNK 240 Query: 239 -KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 K+VGDV F+ + + SYITPVPGGVGPMTV +L+ENTLQAC+ Sbjct: 241 YKIVGDVHFKSTSVKTSYITPVPGGVGPMTVVSLLENTLQACI 283 >UniRef50_A0LE04 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Proteobacteria RepID=FOLD_MAGSM Length = 285 Score = 303 bits (777), Expect = 4e-81, Method: Compositional matrix adjust. Identities = 151/282 (53%), Positives = 198/282 (70%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A +IDGK IAQ VR E+ +V+ PGLAVVLVG++PASQ+YV +K++ACE G Sbjct: 2 AHVIDGKAIAQSVREELRMEVERLKLNHQLTPGLAVVLVGADPASQVYVRNKKRACETAG 61 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 S S++L TTS+AELL LI+ LN D+ + GILVQLPLP ID KVLE I P KD DG Sbjct: 62 IASFSHELAATTSQAELLALIEQLNQDDAVHGILVQLPLPKHIDEQKVLEAISPSKDADG 121 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 FHPYNVGRL P +PCTP G++ +L+ +D G +AVVIG SNIVG+P+++ LL A Sbjct: 122 FHPYNVGRLVTGDPTFQPCTPWGVMEMLKVSGVDPKGKHAVVIGRSNIVGKPVALMLLAA 181 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T T+ H T +L V+ AD+++ AVG+ +PG WIK+GA+VIDVGINR E+GK+ G Sbjct: 182 HATVTICHSRTPDLAETVKRADIVVAAVGRANMVPGSWIKKGAVVIDVGINRGEDGKLCG 241 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 DV + + AS ITPVPGGVGPMT+A L++NT++ H+ Sbjct: 242 DVDYASCFEHASAITPVPGGVGPMTIAMLLKNTVEGAKRAHN 283 >UniRef50_B2V9R3 Methenyltetrahydrofolate cyclohydrolase n=14 Tax=Bacteria RepID=FOLD_SULSY Length = 285 Score = 303 bits (776), Expect = 5e-81, Method: Compositional matrix adjust. Identities = 151/275 (54%), Positives = 200/275 (72%), Gaps = 3/275 (1%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 ++DGK++A+++++++ Q++ G R P L+V+LVG NPASQIYV K K C VG Sbjct: 3 LLDGKSLAEKIKNQIKQEIDQLTQKGYRQPVLSVILVGENPASQIYVNKKIKDCASVGIK 62 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S+ + LPE ++ ELLELI LN D +DGILVQLPLP+ I+ ++++E I+P KDVDGFH Sbjct: 63 SKPFFLPENITQTELLELIGDLNGDEEVDGILVQLPLPSHINTLEIIEAINPYKDVDGFH 122 Query: 125 PYNVGRLCQ-RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL-A 182 P NVG+L R + PCTP GI+ LL YNID FG + VV+GASNIVG+PMS+ L Sbjct: 123 PINVGKLATGRNDAILPCTPYGIMKLLHEYNIDHFGKDVVVVGASNIVGKPMSLLFLKDE 182 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T T+ H+ TK+L+ H AD+L+VAVGKP I D +KEGA+VIDVGINR++ GK+VG Sbjct: 183 KSTVTICHKNTKDLKSHTLKADILVVAVGKPKLITEDMVKEGAVVIDVGINRVD-GKIVG 241 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 DV FE+ K+A ITPVPGGVGPMTVA L+ NTL+ Sbjct: 242 DVDFENVKKKAYAITPVPGGVGPMTVAMLLYNTLE 276 >UniRef50_A3DEE6 Methenyltetrahydrofolate cyclohydrolase n=6 Tax=Bacteria RepID=FOLD_CLOTH Length = 285 Score = 291 bits (745), Expect = 2e-77, Method: Compositional matrix adjust. Identities = 147/278 (52%), Positives = 196/278 (70%), Gaps = 1/278 (0%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M AK+++GK ++ +++ E+ +V+ + PGLAV++VG++PAS++YV SK+KAC E Sbjct: 1 MEAKVLNGKELSTKIKEELKIEVEDLKKNNIN-PGLAVIIVGNDPASRVYVNSKKKACAE 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G S Y L E T++ EL+ELI LN D+ + GILVQLPLP ID KV+ I P KDV Sbjct: 60 IGIESFEYALEENTTQEELIELIHKLNKDDKVSGILVQLPLPKHIDEEKVIYAIDPSKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 D FHP NVG+L P PCTP G++ L++ ID G VV+G SNIVG+PM+M LL Sbjct: 120 DAFHPVNVGKLMIGNPDFLPCTPAGVMELIKESGIDITGKECVVVGRSNIVGKPMAMLLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T TV H T+N+ + AD+L+VAVGKP FI G IK GA+VIDVGINRLEN K+ Sbjct: 180 AQNGTVTVCHSRTQNIDEVCKRADILVVAVGKPEFIKGSSIKPGAVVIDVGINRLENKKL 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 VGDV +E A++ AS ITPVPGGVGPMT+A L++NT++A Sbjct: 240 VGDVEYESASRVASAITPVPGGVGPMTIAMLMKNTVKA 277 >UniRef50_B5YJV1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=FOLD_THEYD Length = 286 Score = 284 bits (726), Expect = 3e-75, Method: Compositional matrix adjust. Identities = 142/278 (51%), Positives = 197/278 (70%), Gaps = 1/278 (0%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M+A+I+DGK++A +++ E+ ++VQ G+ P LAVVLVG N +SQ YV+ K K C+E Sbjct: 1 MSAEILDGKSLALKIKEELKKEVQDLKNQGIN-PCLAVVLVGENKSSQKYVSFKEKTCKE 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 + S + LPE T E L++LID LN ++ ++GIL+QLPLP ++ KVLERI+P KDV Sbjct: 60 LDIQSLVFKLPENTEETSLIKLIDELNENSQVNGILIQLPLPKHLNQNKVLERINPFKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGF P+ +GRL +P PCTP+GI+ +L+ Y I+ G AVVIG S IVG+P+S+ LL Sbjct: 120 DGFTPFCLGRLLIDSPLFIPCTPKGIIRMLDEYKINLEGKQAVVIGRSIIVGKPLSLLLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T T+ H T NL+ + AD+L VA+G+ FI + IK+GA+VID+GIN +GKV Sbjct: 180 KRNATVTMCHSKTINLQDITKKADILCVAIGREKFITSNMIKKGAVVIDIGINVTASGKV 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 VGDV F+D ++ASYITPVPGGVGPMT+A L+EN + A Sbjct: 240 VGDVNFDDVKEKASYITPVPGGVGPMTIAMLMENAIYA 277 >UniRef50_A0M554 Methenyltetrahydrofolate cyclohydrolase n=88 Tax=Bacteria RepID=FOLD_GRAFK Length = 299 Score = 275 bits (704), Expect = 9e-73, Method: Compositional matrix adjust. Identities = 147/289 (50%), Positives = 192/289 (66%), Gaps = 10/289 (3%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+DGK I+ ++ E+A +V G + P LA ++VG + AS YV SK KACE VGF Sbjct: 3 ILDGKKISNDIKDEIAGEVTKIKKRGEKVPHLAAIIVGKDGASMTYVNSKVKACERVGFE 62 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S + LP T SE ELL+ I+ LN ++ IDG +VQLPLP I+ KVL + PDKDVDGFH Sbjct: 63 SSLFRLPHTVSELELLDKIEELNENDDIDGFIVQLPLPPQINTQKVLNAVDPDKDVDGFH 122 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG- 183 P N G++ P TP GI+ LLERY+I T G + VVIG S IVGRPMS+ + +G Sbjct: 123 PTNFGKMALDMTSFIPATPFGILELLERYDIPTKGKHTVVIGRSYIVGRPMSILMGRSGF 182 Query: 184 ---CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL----- 235 T T+TH FTKN+ AD++I+AVG P F+ G+ IK+ A++IDVGI R+ Sbjct: 183 PGNSTVTLTHEFTKNITQVTSQADIIIIAVGIPDFLKGEMIKDDAVIIDVGITRVPDDHA 242 Query: 236 ENGKVV-GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 E G V+ GDV FE+ +KRAS+ITPVPGGVGPMTV+ L++NTL A +H Sbjct: 243 ERGYVIKGDVDFENVSKRASFITPVPGGVGPMTVSMLLKNTLLARERHH 291 >UniRef50_Q11UD1 Methenyltetrahydrofolate cyclohydrolase n=6 Tax=Bacteria RepID=FOLD_CYTH3 Length = 290 Score = 274 bits (700), Expect = 3e-72, Method: Compositional matrix adjust. Identities = 145/288 (50%), Positives = 194/288 (67%), Gaps = 14/288 (4%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +++DGK + Q++ E+ KV+A A G + P LA VLVG + A+ YV +K KACE VGF Sbjct: 2 QLLDGKITSDQIKEELKTKVEAIKAKGGKIPHLAAVLVGDSGAAVTYVNAKVKACELVGF 61 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S LPET +EA+LL + +NAD IDG +VQLPLP ID KV E I PDKDVDGF Sbjct: 62 KSTLVKLPETITEADLLAKVAEINADKDIDGYIVQLPLPKHIDEQKVTEAISPDKDVDGF 121 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA- 182 HP ++GR+ P P TP GI+ LLER I+T G + VV+G S+IVG PMS +L+A Sbjct: 122 HPTSLGRMVLNLPTYLPATPYGIMQLLERNGIETSGKHCVVMGRSHIVGSPMS--ILMAR 179 Query: 183 -----GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 T T+ H TKNL+ AD+LIVA+GKP F+ D +KEGA+V+DVGI+R+++ Sbjct: 180 NTNPGNATVTMVHSRTKNLKELTLQADILIVAIGKPEFVTADMVKEGAVVVDVGIHRIDD 239 Query: 238 G------KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 +++GDV F++ A + SYI+PVPGGVGPMT+A+L+ NTLQA Sbjct: 240 ATKKSGFRLLGDVKFDEVAPKTSYISPVPGGVGPMTIASLLMNTLQAA 287 >UniRef50_A5VAA8 Methenyltetrahydrofolate cyclohydrolase n=107 Tax=cellular organisms RepID=FOLD3_SPHWW Length = 304 Score = 272 bits (695), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 160/283 (56%), Positives = 190/283 (67%), Gaps = 7/283 (2%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQA-RIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A+IIDGK A +R+ VA V A R+AAG RAPGLAVVLVG + ASQ+YV SK KA E Sbjct: 9 AEIIDGKAYAAGLRARVATAVPAFRVAAG-RAPGLAVVLVGEDAASQVYVRSKHKATVEA 67 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S + LP T SE ELL L++ LNAD+ +DGILVQLPLP ID KV+ I PDKDVD Sbjct: 68 GMESFEHRLPATASETELLALVERLNADDRVDGILVQLPLPPHIDEKKVIATIDPDKDVD 127 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GFH N GRL PCTP G + LL+ D GL AVVIG SNIVG+PM+ LL Sbjct: 128 GFHVVNAGRLAVGEAGYVPCTPLGCLMLLKDRRGDLSGLEAVVIGRSNIVGKPMAALLLA 187 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL---ENG 238 CT T+ H T++L V AD+++ AVG+P + GDWI+ GA VIDVGINR+ E G Sbjct: 188 ENCTVTIAHSRTRDLAEVVRRADIVVAAVGRPEMVRGDWIRPGATVIDVGINRVPGAEPG 247 Query: 239 K--VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 K +VGDV F +AA A ITPVPGGVGPMT+A L+ NTL A Sbjct: 248 KTRLVGDVAFAEAAAVAGAITPVPGGVGPMTIAVLLRNTLVAA 290 >UniRef50_A4XY05 Methenyltetrahydrofolate cyclohydrolase n=47 Tax=Proteobacteria RepID=FOLD3_PSEMY Length = 307 Score = 271 bits (693), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 151/278 (54%), Positives = 190/278 (68%), Gaps = 4/278 (1%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 K+IDGK A +V +EVA+ V+A AAG+ P LAVVLVG +PASQ+YV +K EE G Sbjct: 8 KLIDGKAAAARVLAEVAEDVRALKAAGI-VPALAVVLVGDDPASQVYVRNKVLRAEECGI 66 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S + LP T+EA L LI LNAD ++ GILVQLPLPA ID +VL+ + P KDVDGF Sbjct: 67 RSLEFKLPADTAEARLQALIAELNADASVHGILVQLPLPAHIDEQRVLQAVTPLKDVDGF 126 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 H NVG L Q L PCTP G + LL+ D G +AVVIG SNIVG+PM+ LL A Sbjct: 127 HAENVGGLSQGREVLTPCTPAGCLRLLQDSCGDLTGKHAVVIGRSNIVGKPMAALLLKAH 186 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL-ENG--KV 240 C+ TV H + NL+ AD+++ AVG+P + DW+K GA+VIDVGINR+ ENG ++ Sbjct: 187 CSVTVVHSKSANLKTLCRQADIVVAAVGRPRLVDADWLKPGAVVIDVGINRIDENGRSRL 246 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 VGDV F+ A + S ITPVPGGVGPMT+A L++NTL A Sbjct: 247 VGDVDFDSALPQVSAITPVPGGVGPMTIAYLMKNTLVA 284 >UniRef50_Q17W13 Methenyltetrahydrofolate cyclohydrolase n=14 Tax=Helicobacter RepID=FOLD_HELAH Length = 292 Score = 270 bits (689), Expect = 6e-71, Method: Compositional matrix adjust. Identities = 132/274 (48%), Positives = 183/274 (66%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 ++DG+ +A + ++ K+QA + P LAV+LVG +PAS YV K KACE VG Sbjct: 10 LLDGQALAYNIEEDLKYKIQAINTQTHKRPKLAVILVGKDPASITYVNMKIKACERVGMD 69 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 L E +EA+LL LI N + I G+LVQLPLP ID+ + E I P+KDVDGFH Sbjct: 70 FDLKTLQENITEAQLLSLIKDYNNNQNISGVLVQLPLPRHIDSKMISEAIDPNKDVDGFH 129 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 P N+G+LC + P TP G++ LLE Y+I G + +IGASNI+G+P+SM +L AG Sbjct: 130 PLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAIIGASNIIGKPLSMLMLNAGA 189 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 + +V H TK++ + +NAD++ V VGKP I +K+GA+V+D+GIN L +G++VGDV Sbjct: 190 SVSVCHILTKDINFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGDV 249 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 F +A K AS+ITPVP GVGPMT+ +L+ENTL A Sbjct: 250 DFTNAQKVASFITPVPKGVGPMTIVSLLENTLIA 283 >UniRef50_B8HXS0 Methenyltetrahydrofolate cyclohydrolase n=25 Tax=cellular organisms RepID=FOLD_CYAP4 Length = 293 Score = 268 bits (686), Expect = 1e-70, Method: Compositional matrix adjust. Identities = 138/276 (50%), Positives = 186/276 (67%), Gaps = 4/276 (1%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 ++DGK +AQ++++++ +VQA R PGLAV++VG NPAS YV +K +ACE+VG Sbjct: 8 LLDGKALAQEMQADLTLQVQALQTRVGRPPGLAVLMVGDNPASAAYVRNKERACEQVGIA 67 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S + LP T++AELL LI+ LN D +DGILVQLPLP +D +L I P KD DG H Sbjct: 68 SFGHHLPTETTQAELLTLINQLNQDPRVDGILVQLPLPNHLDARALLYAIDPTKDADGLH 127 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 P N+GRL + P LR CTP G++ LL++YNI+ G AVVIG S +VG+P++M LL A Sbjct: 128 PENLGRLVRSEPGLRSCTPAGVMRLLQKYNIELRGKEAVVIGRSILVGKPLAMMLLEADA 187 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL----ENGKV 240 T T+ H + +L AD+LI AVGKPG + +K GA+V+DVGINR+ ++ Sbjct: 188 TVTIAHSRSTDLAEIARRADILIAAVGKPGLVSAGMVKAGAVVVDVGINRVVEATGKSRL 247 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 VGDV F A YITPVPGG+GPMTVA L++NT+ Sbjct: 248 VGDVDFAAVQPIAGYITPVPGGIGPMTVAMLLDNTV 283 >UniRef50_A0K8R4 Methenyltetrahydrofolate cyclohydrolase n=254 Tax=cellular organisms RepID=FOLD_BURCH Length = 285 Score = 268 bits (686), Expect = 1e-70, Method: Compositional matrix adjust. Identities = 146/278 (52%), Positives = 188/278 (67%), Gaps = 1/278 (0%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A +IDG +++ +R++ A++ A A G PGLAV+LVG+NPAS++YV +K KACE+ Sbjct: 1 MTALLIDGNALSKTLRAQAAERAAALTARG-HQPGLAVILVGANPASEVYVRNKIKACED 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 GF S P T SEA+LL ID LN D I GILVQLPLPA ID+ KV+E I P+KDV Sbjct: 60 NGFFSLKDAYPATLSEADLLARIDELNRDPKIHGILVQLPLPAHIDSHKVIEAIAPEKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFH N G L P RPCTP G++ + E + I G NAVVIG SNIVG+PM+M LL Sbjct: 120 DGFHVANAGALMTGKPLFRPCTPYGVMKMFEAHGIALQGANAVVIGRSNIVGKPMAMMLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 AG T T+ H T++L H AD+++ AVGK + D +K GA VIDVG+NR + GK+ Sbjct: 180 DAGATVTICHSKTRDLAAHTREADIVVAAVGKRNILTADMVKPGATVIDVGMNRDDAGKL 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 GDV F + A YITPVPGGVGPMT+ L+ NT+++ Sbjct: 240 CGDVDFAGVKEVAGYITPVPGGVGPMTITMLLINTIES 277 >UniRef50_Q6F9E6 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Acinetobacter sp. ADP1 RepID=FOLD1_ACIAD Length = 297 Score = 265 bits (678), Expect = 1e-69, Method: Compositional matrix adjust. Identities = 152/287 (52%), Positives = 184/287 (64%), Gaps = 6/287 (2%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 KIIDGK IAQ V EV +V+ A G+ P LAVVLVG +PASQ+YV +K + VG Sbjct: 12 KIIDGKAIAQSVLEEVKLEVERYKAQGIE-PCLAVVLVGEDPASQVYVRNKVQKAAFVGI 70 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S + SE ELL ID LN + + GILVQLPLP I+ +VLERIHP KDVDGF Sbjct: 71 RSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVDGF 130 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLL-ERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 H NVG L Q L PCTP G + LL + D GL+AVVIG SNIVG+PM+ LL Sbjct: 131 HSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLLKE 190 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL---ENGK 239 CT TV H T+N+ + AD+++ AVGK I ++K A+VIDVGINR+ E + Sbjct: 191 SCTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGINRIMTHEKTR 250 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 +VGDV FEDA S ITPVPGGVGPMT+A L++NTLQA V PQ Sbjct: 251 LVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQA-VRLQHPQ 296 >UniRef50_D0GMJ6 Bifunctional protein FolD n=2 Tax=Leptotrichia RepID=D0GMJ6_9FUSO Length = 283 Score = 265 bits (676), Expect = 2e-69, Method: Compositional matrix adjust. Identities = 130/276 (47%), Positives = 190/276 (68%), Gaps = 2/276 (0%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 IDGK I+Q++ + ++ + R GLAV++ G+NPAS++YV +K KACE V F S Sbjct: 4 IDGKDISQKILKYIEKEHKLLRDKYERTAGLAVIMAGNNPASEVYVKNKIKACESVKFYS 63 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 L E +EA+ ++ I+ N ++ IDGIL+QLPLP I+ +KV+ + P+KDVDGFH Sbjct: 64 EIVRLDENVTEADFIKEIERFNKNDKIDGILIQLPLPEHINELKVINAVSPEKDVDGFHV 123 Query: 126 YNVGRLCQ-RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 N+G++ PCTP GI+ LLE Y+ID G + V++G SNIVG+P+++ L+ Sbjct: 124 VNIGKMMTGDKSGFWPCTPYGIIQLLEEYDIDPAGKDVVIVGRSNIVGKPLALMLIEKSA 183 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T V + TKN+R ++NAD++I A G P I + IKEGA+VIDVGINR+ NGK+ GDV Sbjct: 184 TVQVCNTKTKNIREKLKNADIVIAAAGVPNLISAEDIKEGAVVIDVGINRV-NGKLCGDV 242 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 +E+ +++A YITPVPGGVGPMT+A+LI+NT ++ + Sbjct: 243 NYEEVSEKAGYITPVPGGVGPMTIASLIKNTFKSYI 278 >UniRef50_Q18GK1 Methenyltetrahydrofolate cyclohydrolase n=15 Tax=cellular organisms RepID=FOLD_HALWD Length = 311 Score = 262 bits (669), Expect = 1e-68, Method: Compositional matrix adjust. Identities = 144/282 (51%), Positives = 180/282 (63%), Gaps = 8/282 (2%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 ++IDG +A +RS++ V RI P LA VL+ +PASQ YV+ K CEEVG Sbjct: 19 QLIDGTEVAASIRSDLISSV-TRIVNTGTTPQLATVLMNDDPASQTYVSMKHDDCEEVGI 77 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 +R + AEL + +D LNAD+++ GILVQ+PLP +D +VL RI P KDVDGF Sbjct: 78 ATRDITIDPEAPAAELFDTVDELNADSSVHGILVQMPLPDHVDEREVLRRIDPKKDVDGF 137 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL--- 180 HP NVGRL PR +PCTP GI LL +I+T G NAVVIG SNIVG+PM+ L+ Sbjct: 138 HPENVGRLVAGQPRYKPCTPHGIQKLLIAADIETEGANAVVIGRSNIVGKPMANLLIQKA 197 Query: 181 -LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL--EN 237 T T H T NL +AD++I A G P I GD I G +VIDVGINR+ EN Sbjct: 198 DAGNATVTTCHSRTNNLASKTRDADIIIAAAGVPEMIDGDMISTGTVVIDVGINRVETEN 257 Query: 238 G-KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 G ++VGDV FE AAK+A ITPVPGGVGPMT A L+ NT++A Sbjct: 258 GSELVGDVEFESAAKKADAITPVPGGVGPMTRAMLLWNTVKA 299 >UniRef50_A8JH65 5,10-methylenetetrahydrofolate dehydrogenase n=4 Tax=cellular organisms RepID=A8JH65_CHLRE Length = 340 Score = 261 bits (668), Expect = 2e-68, Method: Compositional matrix adjust. Identities = 143/285 (50%), Positives = 181/285 (63%), Gaps = 8/285 (2%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A+K+IDGK IA +RSE+A +V PGLAVVLVG+ S+ YV SK+KAC EV Sbjct: 44 ASKLIDGKGIADTIRSEIATEVADMKKQYGLTPGLAVVLVGARKDSETYVRSKKKACAEV 103 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 GF S DLP SE ELL+++ NAD + GILVQLPLP I ++L+ I DKDVD Sbjct: 104 GFDSFGTDLPADVSEEELLKVVAAYNADPRVHGILVQLPLPKHISEKRILDAISIDKDVD 163 Query: 122 GFHPYNVGRLCQRA--PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 GFHP N+G L R P PCTP+G + LLER + G A VIG SNIVG P ++ L Sbjct: 164 GFHPLNIGCLAMRGRDPLFVPCTPKGCIELLERMKVPIAGKKACVIGRSNIVGMPAALLL 223 Query: 180 LLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG- 238 T T+ H T + + AD++I A G + GDWIK GA+VIDVGIN ++ Sbjct: 224 QRRDATVTMVHSKTPDAKKICSEADIVIAACGVAEMVTGDWIKPGAVVIDVGINAKDDAT 283 Query: 239 -----KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 ++VGDV FE AA +AS ITPVPGGVGPMT+A L++NTL++ Sbjct: 284 QKKGYRLVGDVEFEGAAAKASLITPVPGGVGPMTIAMLLQNTLES 328 >UniRef50_Q46A53 Methenyltetrahydrofolate cyclohydrolase n=13 Tax=cellular organisms RepID=FOLD_METBF Length = 287 Score = 261 bits (667), Expect = 2e-68, Method: Compositional matrix adjust. Identities = 131/279 (46%), Positives = 186/279 (66%), Gaps = 2/279 (0%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 ++IIDGK +A+++ EV V+A ++ PGLA VLVG +PAS++YV K +ACE VG Sbjct: 8 SRIIDGKVLAKKIEDEVRSGVEALVSGRGITPGLATVLVGDDPASKMYVRLKHRACERVG 67 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 + + LP TS+ EL+ LI+TLN D + GIL+QLPLP + + +E I P+KD DG Sbjct: 68 IQAEDHFLPAETSQEELISLINTLNKDQNVHGILLQLPLPKHLFPQEAMEAIAPEKDADG 127 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 FHPYN+G+L L PCTP G++ LE YN+ G N V++G SN+VG+P++ L Sbjct: 128 FHPYNMGKLMIGDEGLVPCTPHGVIRALEEYNVPVKGKNVVIVGHSNVVGKPLAAMFLNR 187 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T +V H FT +L+ + +AD+L+VA G I D +KEGA++ DVGI + ++G V G Sbjct: 188 NATVSVCHVFTDDLKKYTLDADILVVATGVKHLIKADMVKEGAVIFDVGITKEKDG-VYG 246 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 DV FE+ K+A+ ITPVPGGVGP+TVA L+++ L C E Sbjct: 247 DVDFENVIKKAALITPVPGGVGPLTVAMLMKHVL-GCAE 284 >UniRef50_Q9X7F6 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Methylobacterium chloromethanicum CM4 RepID=FOLD_METC4 Length = 306 Score = 261 bits (667), Expect = 2e-68, Method: Compositional matrix adjust. Identities = 140/284 (49%), Positives = 181/284 (63%), Gaps = 4/284 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A++IDG+ A ++ V + R PGLAVVL+G +PAS +YV +K + Sbjct: 1 MIAQVIDGRAEAARLTDNVRARAHRFTDEFGRCPGLAVVLIGDDPASSVYVKAKTEKARS 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 G +S S+ LP T+E LL LID LN D T+DGILVQLPLP I +VL+RI P KDV Sbjct: 61 TGILSSSHRLPSDTTEDALLRLIDQLNRDRTVDGILVQLPLPPHIAPERVLQRILPCKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP N G L P L PCTP G + L++ + G N VV+G S IVGRP + L Sbjct: 121 DGFHPVNAGLLATGQPGLVPCTPLGCLRLVQSVAAELVGQNVVVVGRSTIVGRPAAQVFL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL---EN 237 A C+ T+ H+ ++++ H +AD+L+VA G PG + DW+K GA+VIDVGINR+ Sbjct: 181 NADCSVTILHKESRDVPGHCRSADILVVAAGSPGLVRRDWVKPGAVVIDVGINRIPVSSG 240 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 ++VGDV FE AS ITPVPGGVGPMTVA L+ENT+ AC E Sbjct: 241 YRLVGDVDFEGVQYVASAITPVPGGVGPMTVAALMENTV-ACAE 283 >UniRef50_Q2JQ25 Methenyltetrahydrofolate cyclohydrolase n=8 Tax=cellular organisms RepID=FOLD_SYNJB Length = 293 Score = 261 bits (666), Expect = 3e-68, Method: Compositional matrix adjust. Identities = 140/282 (49%), Positives = 184/282 (65%), Gaps = 4/282 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M AKI+DGK +A ++++E+A +VQA I R PGLAV+ VG +PAS YV K +ACE Sbjct: 1 MPAKILDGKALAARLQAEMAAQVQAWIPQVGRPPGLAVLRVGEDPASAAYVRGKERACER 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G S S A LL+ ID LN D +DGILVQLPLP G D + L I+PDKDV Sbjct: 61 LGIASFGRHFSAQDSPAHLLDTIDQLNQDERVDGILVQLPLPPGWDPIPPLLAINPDKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG HP N+GRL + P LR CTP G++ LL+ I G AVV+G S +VG+P+S+ LL Sbjct: 121 DGLHPLNLGRLLRGEPGLRSCTPLGVMRLLQAEGIPIAGRKAVVVGRSILVGKPLSLMLL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-- 238 A T T+ H T +L AD++++AVG+P + D +K GA+VIDVGINR+E Sbjct: 181 AADATVTLAHSRTPDLAEVTRAADIVVMAVGRPRLLRADMVKPGAVVIDVGINRIETPTG 240 Query: 239 --KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 ++VGDV +E + A+ ITPVPGGVGPMTV L+ NTLQ+ Sbjct: 241 AEQLVGDVDYEAVKELAAAITPVPGGVGPMTVTMLLANTLQS 282 >UniRef50_C5R8B8 Bifunctional protein: methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase n=1 Tax=Weissella paramesenteroides ATCC 33313 RepID=C5R8B8_WEIPA Length = 303 Score = 260 bits (665), Expect = 3e-68, Method: Compositional matrix adjust. Identities = 144/285 (50%), Positives = 191/285 (67%), Gaps = 5/285 (1%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 AKIIDGK IA+++RS V+++ A + PGLAV+LVG +PAS+IYV +K +A ++VG Sbjct: 9 AKIIDGKEIAKKLRSAVSEQA-AILKEQSVIPGLAVILVGDDPASEIYVRNKERAAKKVG 67 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 + ++ P T +E E+L+ + LNAD+TID ILVQ P+P+ I+ KV E I P KDVDG Sbjct: 68 VHAVTFKYPSTATEKEILDKVAELNADDTIDAILVQSPVPSQINEQKVQEAIIPSKDVDG 127 Query: 123 FHPYNVGRLCQRAPRLRPC--TPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 FHP NVGRL P TPRGI+T+L+ ID +AVVIG S +VGRPM L Sbjct: 128 FHPENVGRLYANQAGYYPIANTPRGIMTMLQHEKIDLLNKHAVVIGRSILVGRPMFALLQ 187 Query: 181 LAGCTTTVTHRFTKNL--RHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 A + T+ HR+T R + AD+++VA G P + G +K GA+VIDVGINRL N Sbjct: 188 AADTSVTLLHRYTPAALRRELLATADVVVVATGVPDLVMGADLKPGAVVIDVGINRLPNN 247 Query: 239 KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 K+VGDV F A K AS ITPVPGGVGPMT+ATL++ T++ E+H Sbjct: 248 KLVGDVNFGTAEKVASAITPVPGGVGPMTIATLLQTTVELAAEHH 292 >UniRef50_A9HEL1 Methenyltetrahydrofolate cyclohydrolase n=82 Tax=cellular organisms RepID=FOLD_GLUDA Length = 311 Score = 260 bits (664), Expect = 4e-68, Method: Compositional matrix adjust. Identities = 149/280 (53%), Positives = 181/280 (64%), Gaps = 4/280 (1%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A++IDGK A + +A+ VQ+ PGLAVVLVG++PAS++YV +K G Sbjct: 21 ARLIDGKAFAANLTQTIARDVQSFHDRYRVTPGLAVVLVGNDPASEVYVRNKALQTHRAG 80 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 S + LP TTS+AELL LI LNAD I GILVQLPLPAG+D V V I PDKDVDG Sbjct: 81 MRSFMHMLPATTSQAELLALIGRLNADPEIHGILVQLPLPAGLDPVAVTNAILPDKDVDG 140 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 N GRL P + PCTP G + LL+ D GL+AV+IGASN+VGRPM+ LL Sbjct: 141 LGEVNAGRLALGQPGIVPCTPLGCLMLLKSELGDLRGLHAVIIGASNLVGRPMARLLLAE 200 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINR--LENGK- 239 GCT TV H T++ D+L+VA G G + GDWIK GA VIDVGI R L +GK Sbjct: 201 GCTVTVGHIDTRDPAALARQGDILVVATGCHGLVRGDWIKPGAAVIDVGITRISLPSGKT 260 Query: 240 -VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 +VGDV F++A RA ITPVPGGVGPMT+A L+ NTL A Sbjct: 261 RLVGDVAFDEAVTRAGCITPVPGGVGPMTIACLLNNTLAA 300 >UniRef50_Q8LEA3 5,10-methylenetetrahydrofolate dehydrogenase:5,10-methenyltetrahydrofolate cyclohydrolase, putative n=9 Tax=Eukaryota RepID=Q8LEA3_ARATH Length = 299 Score = 260 bits (664), Expect = 5e-68, Method: Compositional matrix adjust. Identities = 142/285 (49%), Positives = 181/285 (63%), Gaps = 8/285 (2%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 AKIIDGK IA +RSE+A++V+ + PGLAVV+VGS SQ YV +KRKAC EVG Sbjct: 9 AKIIDGKAIAHTIRSEIAEEVRGLSEKHGKVPGLAVVIVGSRKDSQTYVNTKRKACAEVG 68 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 S LPE SEA+L+ + LN++ + GILVQLPLP I+ +L I DKDVDG Sbjct: 69 IKSFDVGLPEEVSEADLISKVHELNSNPDVHGILVQLPLPKHINEENILGAISIDKDVDG 128 Query: 123 FHPYNVGRLCQ--RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 FHP N+G+L R P PCTP+G + LL R + G AVV+G SNIVG P+S+ LL Sbjct: 129 FHPLNIGKLAMKGREPLFLPCTPKGCLELLARSGVKIKGQRAVVVGRSNIVGLPVSLLLL 188 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-- 238 A T T H TK+ + AD++I A G+ I G+WIK GA VIDVG N + + Sbjct: 189 KADATVTTVHSHTKDPEAIIREADIVIAACGQAHMIKGNWIKPGAAVIDVGTNAVSDPSK 248 Query: 239 ----KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 ++VGDV F +A+K A +ITPVPGGVGPMTVA L+ NT+ Sbjct: 249 KSGYRLVGDVDFAEASKVAGFITPVPGGVGPMTVAMLLRNTVDGA 293 >UniRef50_Q6GI21 Methenyltetrahydrofolate cyclohydrolase n=83 Tax=Bacteria RepID=FOLD_STAAR Length = 286 Score = 259 bits (663), Expect = 5e-68, Method: Compositional matrix adjust. Identities = 132/278 (47%), Positives = 189/278 (67%), Gaps = 1/278 (0%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M AKI+DGK IA+ R + +V+A G P L+V+LVG++ ASQ YV SK+KA E+ Sbjct: 1 MVAKILDGKQIAKDYRQGLQNQVEALKEKGF-TPKLSVILVGNDGASQSYVRSKKKAAEK 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G +S L ET +E E+L ++ LN D+++ GILVQ+PLP + K+LE I+PDKDV Sbjct: 60 IGMISEIVHLEETATEEEVLNELNRLNNDDSVSGILVQVPLPKQVSEQKILEAINPDKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP N+G+L PCTP GI+ +L+ +ID G NAVVIG S+IVG+P+S LL Sbjct: 120 DGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEGKNAVVIGRSHIVGQPVSKLLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 + T+ H +K++ ++++AD+++ AVGKPG + D +KEGA++IDVG ENGK+ Sbjct: 180 QKNASVTILHSRSKDMASYLKDADVIVSAVGKPGLVTKDVVKEGAVIIDVGNTPDENGKL 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 GDV ++ + A ITPVPGGVGP+T+ ++ NTL A Sbjct: 240 KGDVDYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLA 277 >UniRef50_Q12V26 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=cellular organisms RepID=FOLD_METBU Length = 286 Score = 258 bits (658), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 128/276 (46%), Positives = 182/276 (65%), Gaps = 1/276 (0%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 KIIDG+ IA++V +EV V+ + PGL+ +LVG +PAS++YV K KAC VG Sbjct: 8 KIIDGRAIAKKVEAEVKADVERLVREKGITPGLSAILVGEDPASKMYVRLKHKACGRVGI 67 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + LPE ++ ELLE I +LNA I GIL+QLPLP ++ + + I P KD DGF Sbjct: 68 FAEDQHLPEDITQEELLEAISSLNARKDIHGILLQLPLPKHLNEQEAMNAIDPAKDADGF 127 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 HP+N+G+L L PCTP+GI+ LE Y ++ G +AV++G SN+VG+PM+ L+ Sbjct: 128 HPFNMGQLLIGVEELVPCTPKGIIRALEEYGVEIQGKHAVIVGHSNVVGKPMAAMLVNRN 187 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T ++ H FTK++ +AD+L+VA G I D +KEG+++ DVGI ENGKV GD Sbjct: 188 ATVSICHVFTKDVTKFTRDADILVVATGVKHLIKEDMVKEGSVIFDVGITE-ENGKVYGD 246 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 V FE+ K+AS +TPVPGGVGP+T+ATL+++ L + Sbjct: 247 VDFENVIKKASRVTPVPGGVGPVTIATLMQHVLMSA 282 >UniRef50_O65271 F6N23.26 protein n=34 Tax=Viridiplantae RepID=O65271_ARATH Length = 360 Score = 257 bits (657), Expect = 3e-67, Method: Compositional matrix adjust. Identities = 136/293 (46%), Positives = 185/293 (63%), Gaps = 8/293 (2%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A +IDGK +A+++R E+ +V + PGLAV+LVG S YV +K+KAC+ V Sbjct: 68 GAIVIDGKAVAKKIRDEITIEVSRMKESIGVIPGLAVILVGDRKDSATYVRNKKKACDSV 127 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S L E +SE E+L+ + N D ++ GILVQLPLP+ +D +L + +KDVD Sbjct: 128 GIKSFEVRLAEDSSEEEVLKSVSGFNDDPSVHGILVQLPLPSHMDEQNILNAVSIEKDVD 187 Query: 122 GFHPYNVGRLCQRA--PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 GFHP N+GRL R P PCTP+G + LL RYNI+ G AVVIG SNIVG P ++ L Sbjct: 188 GFHPLNIGRLAMRGREPLFVPCTPKGCIELLHRYNIEIKGKRAVVIGRSNIVGMPAALLL 247 Query: 180 LLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG- 238 T ++ H TKN AD++I AVG+P + G WIK GA++IDVGIN +E+ Sbjct: 248 QREDATVSIIHSRTKNPEEITREADIIISAVGQPNMVRGSWIKPGAVLIDVGINPVEDPS 307 Query: 239 -----KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 ++VGD+ +E+A+K AS ITPVPGGVGPMT+A L+ NTL + H+ Q Sbjct: 308 AARGYRLVGDICYEEASKVASAITPVPGGVGPMTIAMLLSNTLTSAKRIHNFQ 360 >UniRef50_Q82XC3 Methenyltetrahydrofolate cyclohydrolase n=7 Tax=Proteobacteria RepID=FOLD_NITEU Length = 295 Score = 256 bits (655), Expect = 4e-67, Method: Compositional matrix adjust. Identities = 134/278 (48%), Positives = 178/278 (64%), Gaps = 1/278 (0%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M+A II G IA + R E+ Q+V+ ++ PGLAV+L G NPAS +YV +K K CEE Sbjct: 1 MSATIISGSLIASKFREELKQRVKI-LSETWMQPGLAVILAGDNPASCVYVRNKAKTCEE 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G S ++ P S+ LL+ I LN + I GILVQLPLP I +V+ I KDV Sbjct: 60 LGIRSEIFNFPGDISQKALLQQIQDLNVNPEIHGILVQLPLPGHIRIDEVIAAIAIGKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP NVG L PCTP G++ +L Y+I G +AV+IG SNIVG+PM++ LL Sbjct: 120 DGFHPCNVGALVTGHALFHPCTPFGVMKMLAEYDIPLQGQHAVIIGRSNIVGKPMALMLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 G T TV T++L H NAD++++A GK + D I+ GA VIDVGINRL +G++ Sbjct: 180 EKGATVTVCTSRTRDLASHTRNADIVVMAAGKANLLTSDMIRTGATVIDVGINRLADGRL 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 GDV F ++A YITPVPGGVGPMT+ L+ NT++A Sbjct: 240 CGDVEFSGVKEKAGYITPVPGGVGPMTIVMLMNNTIEA 277 >UniRef50_D2QZP8 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2QZP8_9PLAN Length = 293 Score = 254 bits (650), Expect = 2e-66, Method: Compositional matrix adjust. Identities = 139/287 (48%), Positives = 180/287 (62%), Gaps = 10/287 (3%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M +IDG+ I + + E+A++V I RAP LA VLVG +PAS +YV +K ACE Sbjct: 1 MTHVVIDGRAIGRVIELEIAEQVADFIQNNGRAPCLAAVLVGDDPASAVYVKNKHLACER 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG S+ + L +TSE ELL+LI LN D I GILVQLPLP+ I + VL+ +HP KDV Sbjct: 61 VGIESKLHRLAGSTSEEELLDLIAMLNDDPAISGILVQLPLPSQIRSTYVLDAVHPLKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 D FHP NVG L Q PR PCTP G + +L R + G + ++G S+IVGRP++ L Sbjct: 121 DCFHPENVGLLTQGRPRYLPCTPHGCLQILHRTGLSVAGKHVAIVGRSDIVGRPLATLLS 180 Query: 181 ---------LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVG 231 + T T+ H +KNL AD+LI A+GKP F+ D +K GAIVIDVG Sbjct: 181 QKDSHLSPEICNATVTLLHSRSKNLAAMTREADVLIAAIGKPKFVTADMVKPGAIVIDVG 240 Query: 232 INRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 INRL G + GDV F+ A +SYITPVP GVGP+T+ L++NTL A Sbjct: 241 INRLPEG-LCGDVDFDSVAPISSYITPVPKGVGPLTITMLLQNTLAA 286 >UniRef50_UPI0001BC5140 bifunctional protein FolD n=3 Tax=Fusobacterium RepID=UPI0001BC5140 Length = 292 Score = 254 bits (649), Expect = 2e-66, Method: Compositional matrix adjust. Identities = 123/277 (44%), Positives = 175/277 (63%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 K++DGK ++ +++ E+ K++ R PGL ++ +G N A+ +YV S+ K +G Sbjct: 2 KLLDGKKVSAEIKEELKSKIREEKERSGRVPGLGIIQIGHNEAASVYVQSQLKGSRALGM 61 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S Y ++ E +L+ I LN IDGI++QLPLP I + ++L+ I +KDVDGF Sbjct: 62 ESYLYSFDDSVEEETVLKKIKELNQTEEIDGIILQLPLPKHISHSRILQAIDVNKDVDGF 121 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 N+GRL PCTP G++ LL++Y+I+ N +IG SNIVG+PM + Sbjct: 122 KTENIGRLHLGEEGFNPCTPEGVIALLKKYDIEIASKNVTIIGRSNIVGKPMLGLFINHN 181 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T T+ + TKNL+ H E AD+++VAVGK F+ D ++EGAIVIDVGINR GK+VGD Sbjct: 182 ATVTICNSLTKNLKEHTERADIIVVAVGKEKFLTADMVREGAIVIDVGINRSREGKIVGD 241 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 V FE A +ASYITPVPGGVG MTVA L +N +A + Sbjct: 242 VDFEAVAPKASYITPVPGGVGSMTVAMLFQNIWKAFI 278 >UniRef50_B0KLM9 Methenyltetrahydrofolate cyclohydrolase n=184 Tax=Bacteria RepID=FOLD2_PSEPG Length = 303 Score = 254 bits (649), Expect = 2e-66, Method: Compositional matrix adjust. Identities = 147/278 (52%), Positives = 188/278 (67%), Gaps = 4/278 (1%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 K+IDGK A +V +EV ++VQ G++ PGL VVLVG++ ASQ+YV +K EEVG Sbjct: 8 KLIDGKATAARVLAEVREQVQELRQGGVQ-PGLVVVLVGADAASQVYVRNKVLRAEEVGI 66 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S+ + LP T++A LL LID LN D ++GILVQLPLPA ID VL+ I+P KDVDGF Sbjct: 67 RSQEHRLPADTTQAHLLTLIDRLNRDPEVNGILVQLPLPAHIDEHCVLQAINPLKDVDGF 126 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 H NVG L Q L PCTP G + LL + G +AVV+G SNIVG+PM+ LL A Sbjct: 127 HSENVGGLAQGRDVLTPCTPSGCMRLLRDACGELRGKHAVVVGRSNIVGKPMAALLLQAD 186 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL-ENGK--V 240 CT TV H +++L AD+L+ AVGKP I D +K GA+VIDVGINR+ E+G+ + Sbjct: 187 CTVTVVHSRSRDLPALCRQADILVAAVGKPRLIGADCLKPGAVVIDVGINRINEDGQNHL 246 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 VGDV F A + + ITPVPGGVGPMT+A L++NTL A Sbjct: 247 VGDVDFAAALPQVAGITPVPGGVGPMTIAYLMKNTLLA 284 >UniRef50_Q1II76 Methenyltetrahydrofolate cyclohydrolase n=15 Tax=Bacteria RepID=FOLD_ACIBL Length = 307 Score = 253 bits (647), Expect = 4e-66, Method: Compositional matrix adjust. Identities = 137/299 (45%), Positives = 187/299 (62%), Gaps = 22/299 (7%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A I+DG I+ ++++EVA +V A GL PGLAVVLVG NPAS+IYV +K KACE Sbjct: 1 MLATILDGNKISAEIKTEVAAEVAELKAKGL-TPGLAVVLVGHNPASEIYVRNKVKACEM 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 G S + P+T S A+LL+L+++LN N IDGILVQLPLP +D+ K+L + P+KDV Sbjct: 60 TGIYSEQHTPPDTVSTADLLQLVESLNRRNDIDGILVQLPLPKQVDSKKILLAVSPEKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP NVG L P L PCTP G + +L R N+ G +AVV+G S+IVG+P++M L Sbjct: 120 DGFHPMNVGYLSTVRPGLVPCTPAGCMEILRRSNVPVEGADAVVVGRSDIVGKPIAMLLT 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 A T T+ H T +L AD+L+ A+G+PG I D++K GA V+DVGIN++ + Sbjct: 180 NANATVTICHSKTHDLPAVCRRADILVAAIGRPGMITPDFVKPGATVLDVGINKITDRAE 239 Query: 241 VGDVVFEDAAKRASY---------------------ITPVPGGVGPMTVATLIENTLQA 278 DA + A++ TPVPGGVGP+T+A L+ NT++A Sbjct: 240 FEKFFAGDAKREAAFAKNGSTLVGDCHPKVAEVAGAFTPVPGGVGPLTIAMLMANTVKA 298 >UniRef50_C8P269 Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase n=1 Tax=Erysipelothrix rhusiopathiae ATCC 19414 RepID=C8P269_ERYRH Length = 284 Score = 250 bits (639), Expect = 4e-65, Method: Compositional matrix adjust. Identities = 131/274 (47%), Positives = 180/274 (65%), Gaps = 2/274 (0%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+DG +++ +R+ + + + I G RAP L VV+VG +PASQ YV SK K C+ VGF Sbjct: 4 ILDGLAVSKAIRASLKDETEVLIKQGKRAPSLTVVIVGDDPASQTYVNSKVKQCKSVGFS 63 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S++ T++ LL++I TLN DN +DGILVQLPLP ID ++E I P KDVDG H Sbjct: 64 SQAISCEVDTTQEALLKIIRTLNHDNDVDGILVQLPLPKHIDENVIIEAIDPQKDVDGLH 123 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 P NVG L P CTP+GIV LL+ YN++ G A+VIG S +VG+P+S L Sbjct: 124 PLNVGYLELNRPGFVSCTPKGIVRLLDWYNVELEGKRALVIGRSRLVGKPVSTLLSQKNA 183 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+ H TKNL V + D+++VA+GKP IP WI + +++DVGI+R++ G + GD Sbjct: 184 TVTLAHSKTKNLEELVRSNDIIVVAMGKPEAIPASWISDQHVLVDVGIHRID-GNLRGD- 241 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 V A + A+Y TPVP GVGPMT+A+L+ENT+ A Sbjct: 242 VDRRAYEIAAYATPVPKGVGPMTIASLLENTMIA 275 >UniRef50_C7TD85 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase n=5 Tax=Bacteria RepID=C7TD85_LACRG Length = 283 Score = 249 bits (637), Expect = 6e-65, Method: Compositional matrix adjust. Identities = 131/271 (48%), Positives = 182/271 (67%), Gaps = 1/271 (0%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 +DG+ +++++ E+ Q V A++A P LAVVLVGS+PAS++YV +K++ EE+G S Sbjct: 5 LDGRVVSKKILGELKQTV-AKLAQQDVTPTLAVVLVGSDPASEVYVRNKQRRAEEIGVRS 63 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 Y LPE TS+ LL + LN D +D ILVQLPLPAG+D V++ I P+KDVDGF P Sbjct: 64 LMYRLPEDTSQMTLLAKVAELNQDPDVDAILVQLPLPAGLDERAVIDAIDPNKDVDGFSP 123 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCT 185 +VGRL P + TP GI+ LL+ Y+ID G V++G SNIVGRP++ ++ T Sbjct: 124 VSVGRLWTNEPTVVASTPYGIMALLDAYDIDVAGQRVVIVGRSNIVGRPLAGLMVNHDAT 183 Query: 186 TTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVV 245 T+ H T+NL+ AD+L+VAVG+P FI D +K GA VIDVGI+R +GK+ GDV Sbjct: 184 VTIAHSKTRNLKQLTREADILVVAVGRPHFIGADAVKPGATVIDVGISRGADGKLHGDVD 243 Query: 246 FEDAAKRASYITPVPGGVGPMTVATLIENTL 276 + A A +TPVPGGVGPMT+A+L+ T+ Sbjct: 244 DDTVAPIAGALTPVPGGVGPMTIASLMAQTV 274 >UniRef50_Q03RR1 Methenyltetrahydrofolate cyclohydrolase n=22 Tax=Bacteria RepID=FOLD_LACBA Length = 288 Score = 249 bits (636), Expect = 7e-65, Method: Compositional matrix adjust. Identities = 137/277 (49%), Positives = 180/277 (64%), Gaps = 3/277 (1%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 IIDGK IA+ + ++ A +V A + PGLAV++VG +PAS IYV +K K ++G Sbjct: 4 IIDGKQIAKDLNAQTATRVAALKKRDI-VPGLAVIVVGDDPASAIYVRNKHKKALKLGIK 62 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S +LP TT++AEL +++ N D TI GILVQ PLPAG+D ++ I P KDVDGFH Sbjct: 63 SVVRELPATTTQAELTQIVMAYNVDPTIHGILVQSPLPAGLDEQAIVAAIDPQKDVDGFH 122 Query: 125 PYNVGRLCQRAPRLRP--CTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 P NVGRL P P CTPRGI+T+L + G AVV+G S IVGRPM+ LL A Sbjct: 123 PLNVGRLFANLPGKYPVSCTPRGIMTMLATLPMHLRGKRAVVVGRSLIVGRPMAAMLLNA 182 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T +V H T++L AD+L+VA G I +K GA+VIDVG++R ENGK+ G Sbjct: 183 DMTVSVAHVHTQHLSDLTRTADVLVVATGVTHLIKATDVKPGAVVIDVGMDRDENGKLTG 242 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 DV F++ A R + ITPVPGGVGPMT+ATL++ T+ C Sbjct: 243 DVDFDNVAPRVAAITPVPGGVGPMTIATLMQQTVDLC 279 >UniRef50_C8W0Y6 Methylenetetrahydrofolate dehydrogenase (NADP(+)) n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8W0Y6_DESAS Length = 287 Score = 248 bits (633), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 128/281 (45%), Positives = 187/281 (66%), Gaps = 5/281 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 MAA+++ GK IA +++ EV+ +V+A A G+ P L + VG N AS +Y +++K E Sbjct: 1 MAAELLKGKPIADKIKVEVSAEVEALKAKGV-TPFLVAIQVGENAASAVYTGAQKKVAES 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G +LP T++ EL++ I+ LNAD+ + GI++Q+PLPA ID +I KDV Sbjct: 60 LGIRYELRELPAETTQEELIKYIEGLNADDEVKGIILQMPLPAQIDARAAQWKIAYSKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 +G P+NVG + APRL PCTP G V L++ +D +G VV+G S+IVG+P +M LL Sbjct: 120 EGMTPHNVGLVTYFAPRLAPCTPAGAVELIKSTGVDLYGKEVVVVGHSDIVGKPTAMLLL 179 Query: 181 LAGCTTTVTHRFTKN---LRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 CT T+ H T HV NA++++VAVG PG + G+WIKEGAIVID+GIN++ + Sbjct: 180 KEFCTVTICHIATGQRGLTAQHVGNAEIVVVAVGVPGIVKGEWIKEGAIVIDIGINKVGD 239 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 K+VGDV FE A+++A+YITPVPGG G T A L++N ++A Sbjct: 240 -KIVGDVEFEAASEKAAYITPVPGGAGVATTAMLMKNLVEA 279 >UniRef50_C4FUB1 Putative uncharacterized protein n=1 Tax=Catonella morbi ATCC 51271 RepID=C4FUB1_9FIRM Length = 294 Score = 246 bits (628), Expect = 7e-64, Method: Compositional matrix adjust. Identities = 133/282 (47%), Positives = 178/282 (63%), Gaps = 2/282 (0%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 +DGKT++Q + + ++Q A + P L V+ VG +PAS++YV K+K E+G+ Sbjct: 4 LDGKTLSQSIFARLSQATAAFRSQTGTQPKLTVISVGEDPASKVYVGQKQKRALEIGYAF 63 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 LP S+ EL I N D G+L+QLPLP +D + + I P+KDVDGFHP Sbjct: 64 EWMLLPADISQEELERTIKVHNQDPQTHGLLLQLPLPDHLDPLSAMHLIDPEKDVDGFHP 123 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCT 185 +GR+ + L PCTP+GIV LLE I G N VV+G S IVG P+S+ L+ G T Sbjct: 124 LTMGRVVEDNTDLYPCTPKGIVRLLENAQIPLQGQNVVVVGRSQIVGLPISIMLINRGAT 183 Query: 186 TTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVV 245 TV + T++L H+ AD+LIVA G+ I D +KEGA+V+DVGINRL +GK+VGDV Sbjct: 184 VTVCNSKTQDLGHYTRYADILIVATGQAHLIGPDHLKEGAVVVDVGINRLMSGKLVGDVD 243 Query: 246 FEDAAKRASYITPVPGGVGPMTVATLIENTLQ-ACVEYH-DP 285 FE A + SYITPVPGGVGPMTVA L+E T AC + + DP Sbjct: 244 FEAVAHKVSYITPVPGGVGPMTVAMLMEQTFTCACQQQNLDP 285 >UniRef50_Q14NV1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Spiroplasma citri RepID=FOLD_SPICI Length = 286 Score = 245 bits (626), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 122/274 (44%), Positives = 176/274 (64%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 KIIDGK +++ +++++ +++ A R P L ++ +G+N AS Y+ +K+ ACE+VG Sbjct: 4 TKIIDGKMVSELIKAKITEQILKIKAKKQRVPALTIIQIGNNKASTTYIKNKKIACEKVG 63 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 + + P+ +E+ L+++I+ LN ++ ID ILVQLPLP+ I++ KV+ I KDVDG Sbjct: 64 VTCKVLNYPDIITESALIKIINDLNNNSKIDAILVQLPLPSHINSEKVINTIITKKDVDG 123 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 F P +G L L P TP+GI+ LL+ Y I G + V+IG SNIVG+P++ L+ A Sbjct: 124 FTPKILGNLMLGHYNLLPSTPKGIIALLKHYQIQLAGQHVVIIGRSNIVGKPLANLLINA 183 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T TV H TKNL AD+LI AVGK F+ + IKE IVIDVGINR E+ + G Sbjct: 184 SATVTVCHSQTKNLSDFTNQADILISAVGKAKFVTAEMIKENVIVIDVGINRDEDNNLCG 243 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 D+ F + + ITPVPGGVGPMT+A L+EN L Sbjct: 244 DIDFHNVFSKVKMITPVPGGVGPMTIAALLENIL 277 >UniRef50_Q8DMU0 Methenyltetrahydrofolate cyclohydrolase n=80 Tax=Bacteria RepID=FOLD_THEEB Length = 306 Score = 245 bits (625), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 141/289 (48%), Positives = 191/289 (66%), Gaps = 4/289 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 AA +DGK++AQ + ++A V+ A R+PGLAV+ VG++PAS +YV +K +AC V Sbjct: 5 AATCLDGKSLAQSIERQLADHVRTFQAQWGRSPGLAVLRVGNDPASAVYVRAKEQACSRV 64 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S LP T +EA LL I LN D +DGIL+QLPLP +D +L IHPDKDVD Sbjct: 65 GIQSFGAHLPATITEAALLAKITELNQDERVDGILLQLPLPPHLDPRPLLYAIHPDKDVD 124 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G HP N+GRL + P LR CTP G++ LL Y ID G +AVV+G S +VG+P+++ LL Sbjct: 125 GLHPENLGRLVRDEPGLRSCTPAGVMQLLAAYGIDVVGRSAVVVGRSILVGKPLALMLLS 184 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE--NGK 239 A T T+ H ++ L +A++L+ A+G+P I D I+ GA+VIDVGINR++ +GK Sbjct: 185 ANATVTIAHSRSRELASITRSAEILVTAMGQPRRITADMIRPGAVVIDVGINRIQRPDGK 244 Query: 240 --VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 + GDV +E A ASYITPVPGGVGPMTVA L+ NT+ + H+ Q Sbjct: 245 SSLWGDVDYEAARAVASYITPVPGGVGPMTVAMLLHNTVWSYCRRHNWQ 293 >UniRef50_D0J906 Putative methenyltetrahydrofolate cyclohydrolase n=1 Tax=Blattabacterium sp. (Periplaneta americana) str. BPLAN RepID=D0J906_BLASP Length = 292 Score = 244 bits (624), Expect = 2e-63, Method: Compositional matrix adjust. Identities = 129/287 (44%), Positives = 183/287 (63%), Gaps = 8/287 (2%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARI-AAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 ++++G +A +R E++++++ I R P L ++L+G+N +S YV SK + C+ + Sbjct: 2 TQLLNGNKLAIDIRKEISKEIEKSIRNKKKRLPHLGIILLGTNSSSLTYVNSKIQECKNI 61 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S LP +SE ELL+ I +N + IDG +VQLPL I++ K++ I+P KDVD Sbjct: 62 GIKSSLIHLPNDSSEKELLKEIQKMNNNPLIDGFIVQLPLQKHINSDKIIMSINPRKDVD 121 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRP----MSM 177 GFHP N G++ P T GI+T+LERY I+ G + VVIG S IVGRP MS Sbjct: 122 GFHPENFGKMSLDMKAFFPATALGILTILERYKIEISGKHTVVIGRSRIVGRPISILMSR 181 Query: 178 ELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 + L T T+TH T N+ ++ + AD++I AVG+PGF+ G IKEGAIVIDVGI +++N Sbjct: 182 KNYLGNSTVTLTHSQTPNIDYYTKQADIIITAVGRPGFLTGKMIKEGAIVIDVGITKVKN 241 Query: 238 GK---VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 GK + GDV F +ASY+TPVPGGVGPMT LI+NTL A + Sbjct: 242 GKKSFLKGDVDFNSVYGKASYLTPVPGGVGPMTRIMLIKNTLIAALN 288 >UniRef50_C2E8X3 Methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase n=1 Tax=Lactobacillus ruminis ATCC 25644 RepID=C2E8X3_9LACO Length = 284 Score = 244 bits (623), Expect = 2e-63, Method: Compositional matrix adjust. Identities = 117/274 (42%), Positives = 182/274 (66%), Gaps = 1/274 (0%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +I++G+ ++ +V+ + + V+ G+ P LAV+LVG + AS++YV +K +A E++G Sbjct: 3 EIMNGRDLSAKVKMNLKKSVEGLKKVGV-TPALAVILVGDDEASKVYVKNKHRAAEKIGI 61 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + +P + + +++++I+ N D + GILVQ+PLP ID +++ I P KDVDG Sbjct: 62 KTIDETMPADSKQEDVIKMIEKYNNDPDVHGILVQMPLPKHIDEKAIIDAIDPKKDVDGS 121 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 HP N+GRL + PCTPRGI+ LL+ Y+ID G V++G SN+VGRP++ ++ + Sbjct: 122 HPENMGRLFMNESQALPCTPRGIMELLKEYDIDVRGQEVVIVGRSNLVGRPLAALMINSS 181 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T TV H T +L+ + AD+L+ AVGK D+IKEGA+VIDVGINR GK+ GD Sbjct: 182 ATVTVAHSVTHDLQSVTKKADILVAAVGKAKMFTKDYIKEGAVVIDVGINRTAEGKLCGD 241 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 V +D +A+++TPVPGGVGPMTVA L++ T++ Sbjct: 242 VDAKDVMGKAAFLTPVPGGVGPMTVAMLMKQTVE 275 >UniRef50_A2BX55 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=cellular organisms RepID=FOLD_PROM5 Length = 298 Score = 243 bits (621), Expect = 5e-63, Method: Compositional matrix adjust. Identities = 121/276 (43%), Positives = 178/276 (64%), Gaps = 5/276 (1%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 +DGK ++ ++ ++ + +++ I + R PGLAV+ +G +PAS +YV +K +AC VG S Sbjct: 5 LDGKKLSLEIEEKLKKDIESNINSTKRPPGLAVIRIGEDPASGVYVKNKERACARVGIKS 64 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 + L +T + E+ +LI+ LN DN IDG+L+QLP+P D +++ I+PDKDVDG + Sbjct: 65 FIFHLKDTIDQKEVEQLINKLNLDNDIDGMLLQLPIPDKFDEQRLISLINPDKDVDGLNE 124 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCT 185 N+G+L + P +R CTP GIV LL NI G VV+G S +VG+P+S+ LL T Sbjct: 125 KNIGKLVKNEPGMRSCTPAGIVNLLRSQNITIEGKKIVVVGRSLLVGKPLSLMLLNLNGT 184 Query: 186 TTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-----KV 240 T+TH T NL+ + AD+LI A GKP I ++K+GA++IDVGI+RL + K+ Sbjct: 185 VTITHSKTINLKKICKEADILIAAAGKPNLINSSYVKDGAVIIDVGIHRLTSSDKSQTKL 244 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 GDV+ ED + TPVPGGVGPMTV L+ NT+ Sbjct: 245 CGDVLLEDVIPKVYAYTPVPGGVGPMTVTMLLVNTI 280 >UniRef50_A9A4N5 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=Thaumarchaeota RepID=FOLD_NITMS Length = 287 Score = 243 bits (621), Expect = 5e-63, Method: Compositional matrix adjust. Identities = 131/280 (46%), Positives = 178/280 (63%), Gaps = 4/280 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M IDGK I+Q V+ V + V+ G+ P LA VLVG NPAS YV +K +ACEE Sbjct: 1 MTGTKIDGKVISQSVKDRVKKAVEELKNQGIN-PCLATVLVGDNPASATYVRNKHRACEE 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG ++ + L +T++A+L E+I+ LN DN++ GILVQLPLP +D RI P KDV Sbjct: 60 VGITTKDHKLDASTTQAQLNEIIENLNNDNSVHGILVQLPLPEQLDEFTTTSRISPLKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG P+N G L + L CTP G++ + + + I+ G N V+I SN+VG+P+ LL Sbjct: 120 DGLTPHNAGLLAMKKAALVACTPSGVMEMFDYHGIELEGKNIVLINRSNLVGKPLYHLLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVG-KPGF-IPGDWIKEGAIVIDVGINRLENG 238 T H TKNL ++AD++I AVG + F + D IKEGAIVIDV I+R + Sbjct: 180 DKNATVITCHSRTKNLVELCQSADIIITAVGDRNKFTLTSDMIKEGAIVIDVAISRFQE- 238 Query: 239 KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 K+VGD +ED ++AS+ TPVPGGVGPMTVA L++NT+ A Sbjct: 239 KLVGDADYEDIIQKASFATPVPGGVGPMTVAMLLKNTITA 278 >UniRef50_B3ESU1 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Bacteria RepID=FOLD_AMOA5 Length = 298 Score = 243 bits (619), Expect = 8e-63, Method: Compositional matrix adjust. Identities = 132/295 (44%), Positives = 177/295 (60%), Gaps = 12/295 (4%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A I+DGK +A +R +A++VQ G P LA+VLVG +PAS YV +K KAC+EVG Sbjct: 2 AVILDGKQVAHFLRQSLAEQVQTLAKEGKPIPHLAIVLVGDDPASHTYVYNKVKACQEVG 61 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 F + E+ LL LI LN D +I GI++QLPLP I+ +K+++ I P KDVDG Sbjct: 62 FQTTFIQEASHVQESTLLYLIHKLNEDTSIHGIIIQLPLPKHINAIKIIQAITPSKDVDG 121 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL--- 179 H +N GR+ P P TP GI+ LLE Y I+T G + V+IG VG P+S+ + Sbjct: 122 LHTFNYGRMACNLPTHIPATPLGILLLLEHYQIETAGKHCVIIGRGPTVGAPLSILMSRN 181 Query: 180 -LLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 T T+ H +T+ L + AD+L+VAVGKPG I D IK VIDVGI R+ + Sbjct: 182 AYPGNATVTLCHSYTQQLTNFTRQADILVVAVGKPGLITADMIKPSTTVIDVGITRIPDT 241 Query: 239 ------KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE--YHDP 285 ++ GDV FE+ A + ITPVPGGVGPMT+A L+ NTL+A Y+ P Sbjct: 242 TKKRGYRLKGDVAFEEVATLCNAITPVPGGVGPMTIAALLTNTLRAATNQVYNTP 296 >UniRef50_Q049N0 Methenyltetrahydrofolate cyclohydrolase n=18 Tax=Firmicutes RepID=FOLD_LACDB Length = 283 Score = 242 bits (617), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 123/280 (43%), Positives = 186/280 (66%), Gaps = 2/280 (0%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +I+DGK +A+++ ++ +V + G+ +P L V+ +G +PAS++YVASK++ E++G Sbjct: 3 EILDGKKLARELGEKLGSEVDSLKEHGV-SPKLCVINIGDDPASKVYVASKKRKAEKLGI 61 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 Y LP SE ++L+LID+LNAD + ++VQLP+P I+ +V+ERI P+KDVD Sbjct: 62 KQVVYQLPADESEEDVLKLIDSLNADPEVSSLMVQLPVPPQINADRVIERIDPEKDVDCL 121 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 P N+GRL Q + P T GI+ LL+ Y ID G NAV++G SNIVG+P++ +L Sbjct: 122 TPANIGRLWQGKHFVEPATAAGIIALLDHYQIDLTGKNAVIVGRSNIVGKPLAALMLERN 181 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 + ++ H ++NL + AD+L+ AVGK I D +KEGA+VIDVGINR+ +G +VGD Sbjct: 182 ASVSILHSRSRNLADLTKQADILVCAVGKAEMIKADMVKEGAVVIDVGINRV-DGHLVGD 240 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 V F ++AS+ITPVPGGVGP+TV L+E ++ H Sbjct: 241 VDFAPVKEKASWITPVPGGVGPLTVEFLMEEVIKLTRRQH 280 >UniRef50_C8PLX3 Bifunctional protein FolD n=1 Tax=Treponema vincentii ATCC 35580 RepID=C8PLX3_9SPIO Length = 304 Score = 242 bits (617), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 135/287 (47%), Positives = 183/287 (63%), Gaps = 7/287 (2%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A+IIDGK +A+Q+ V ++ A P LA+V G++PASQ+Y+ +K KA E+ G Sbjct: 2 AQIIDGKRLAEQLTQAVTRE-NAAYCTRHPQPCLAIVSSGTDPASQVYIKTKIKALEKAG 60 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 SR +T SE EL + TLNAD+T+DGIL+QLPLP +D+ ++L + P KD+DG Sbjct: 61 MRSRIIPYSQTISEEELTACVQTLNADDTVDGILIQLPLPYPLDSRRILAPLAPHKDIDG 120 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 F P N+GRL P PCTP+GI+ L Y I G +AV++G S IVG+P++ L A Sbjct: 121 FTPENLGRLLTGRPGFIPCTPQGILYALREYGIPLSGAHAVIVGRSAIVGKPLAALLTAA 180 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL------E 236 T T+ H TK+L AD+LI A G PG I G IK+GA VIDVGINR+ + Sbjct: 181 DATVTLCHSKTKDLAAITRQADILIAAAGHPGLITGSMIKKGAAVIDVGINRIPDPSAPK 240 Query: 237 NGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 ++ GDV FE AA++A +ITPVPGGVGP+TVA ++ NTL+A H Sbjct: 241 GSRLTGDVDFESAAEQAGWITPVPGGVGPLTVAMVLRNTLRAAQLRH 287 >UniRef50_Q8RAD0 Methenyltetrahydrofolate cyclohydrolase n=11 Tax=Thermoanaerobacterales RepID=FOLD_THETN Length = 280 Score = 242 bits (617), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 123/278 (44%), Positives = 178/278 (64%), Gaps = 6/278 (2%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M IIDGK I+ +++ EV +++Q G + P LA+++ G + +S++Y SK KACE Sbjct: 1 MKRMIIDGKEISNRIKEEVKREIQE---FGYK-PRLAILMAGDDESSKVYANSKVKACES 56 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG ++ Y E E + + ++ LN D GI++++PLP G D KV + I+P KDV Sbjct: 57 VGIEAKVYYFSEK-EEDKFFDTLEKLNEDKDTHGIMIEMPLPKGFDVDKVYDTINPYKDV 115 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 D YN+GRL P PCTP+ I+ +LE +D G +AVVIG SNI+G+P++ LL Sbjct: 116 DCISNYNMGRLFAGKPLFVPCTPKAIIHILENTGVDLEGKHAVVIGRSNILGKPVAKLLL 175 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 CT TV H TK+L +H + AD+L+VA GK + GD +KEG ++ID GIN + GK+ Sbjct: 176 DKNCTVTVCHSKTKDLAYHTKQADVLVVAAGKMNLVRGDMVKEGVVLIDAGIN-VHEGKI 234 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 GD FE +ASY+TPVPGGVGP+T A +++NTL+A Sbjct: 235 YGDADFESIKDKASYVTPVPGGVGPVTTAMILKNTLEA 272 >UniRef50_UPI00016C0DE6 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016C0DE6 Length = 282 Score = 241 bits (615), Expect = 2e-62, Method: Compositional matrix adjust. Identities = 129/278 (46%), Positives = 175/278 (62%), Gaps = 9/278 (3%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAP---GLAVVLVGSNPASQIYVASKRKACEE 60 K IDG IA ++ EV V+A AP GL+V+ V +N ++QIY+ +K+KAC+ Sbjct: 6 KKIDGTKIASIIKQEVKDAVEAM------APETVGLSVITVQTNSSAQIYIKNKQKACDY 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG S+ Y L E+++ +LELI+ LN +++DGILVQLPLP +D ++ I P KDV Sbjct: 60 VGIKSQIYTLDESSTTNNVLELIEVLNDSHSVDGILVQLPLPKHMDQSTIIAAISPSKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGF N+ L CTP GI+ LL+ NI+ G V+IG SNIVG+P+++ LL Sbjct: 120 DGFSKENLAGLIAGGSSFESCTPLGIMALLKHENIEIAGKKCVIIGRSNIVGKPLALMLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T + H T NL + ++ AD+LI AVGK FI G IK A+VIDVGI ENGK+ Sbjct: 180 NEDATVCICHSKTVNLANEIKTADILISAVGKAKFITGAMIKPKAVVIDVGITHDENGKL 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 GDV F+ A YITPVPGGVGPMT+A L++N ++A Sbjct: 240 CGDVDFDSCLGIAEYITPVPGGVGPMTIAMLLKNCVRA 277 >UniRef50_D1AX33 Methylenetetrahydrofolate dehydrogenase (NADP(+)) n=1 Tax=Streptobacillus moniliformis DSM 12112 RepID=D1AX33_STRM9 Length = 285 Score = 241 bits (614), Expect = 3e-62, Method: Compositional matrix adjust. Identities = 123/280 (43%), Positives = 182/280 (65%), Gaps = 3/280 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M ++DG+ ++ + ++ + Q I + GLA + VG++ AS IY+ +K K C+E Sbjct: 1 MIKSMLDGRYVSNILYEKLKIEYQILIDKIGKRAGLAFIKVGNDRASTIYLKNKAKKCDE 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G ++ E +E EL+ I+ LN D IDGIL+QLPLP+ I+ + V+ I+P KDV Sbjct: 61 LGIYQKTIIFEENITETELISEINKLNDDKNIDGILLQLPLPSHINYISVMSTINPKKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP NVG L + + CTP+GI+ LL YNI + V+IG SNIVG+P+++ L+ Sbjct: 121 DGFHPENVGNLLFKDKGIYSCTPQGIMELLNYYNISIESKDIVIIGRSNIVGKPLALMLI 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 G T V + TK+L + + AD+LI A G I ++IK+GA+VIDVGI+ E GK+ Sbjct: 181 NEGATVQVCNSKTKDLFNKTKQADILISATGVSHLIKSEYIKDGAVVIDVGISEFE-GKI 239 Query: 241 VGDVVFEDAAKRAS--YITPVPGGVGPMTVATLIENTLQA 278 +GDV FED + ++ YITPVPGGVGPMT+ +LI+NT++A Sbjct: 240 IGDVDFEDVIQNSNVRYITPVPGGVGPMTIYSLIKNTIRA 279 >UniRef50_A8ZTQ4 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=Bacteria RepID=FOLD_DESOH Length = 303 Score = 240 bits (613), Expect = 4e-62, Method: Compositional matrix adjust. Identities = 138/295 (46%), Positives = 179/295 (60%), Gaps = 17/295 (5%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M+AK+I G I +++ E+ +V+ + PGL +LVG +PAS YV K + Sbjct: 1 MSAKLIKGTEIREEILKEIEAEVKEIKEKHGKVPGLVTILVGESPASISYVTLKIQTAHR 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VGF P SEA+LL LID N D++I GILVQLPLP ID KVL I PDKDV Sbjct: 61 VGFKEVQDSQPVDISEADLLALIDKYNKDDSIHGILVQLPLPKHIDEKKVLNAIDPDKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLR--PCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSME 178 DGFHP NVGRL ++ PCTP GI ++ R ++T G VV+G SNIVG+P++ Sbjct: 121 DGFHPVNVGRLMIGGSEVKFPPCTPAGIQEMIVRAGVETSGAEVVVVGRSNIVGKPIANM 180 Query: 179 LLLAG----CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINR 234 +L G T TV H TKN+ H + AD+LIVA G PG + +WIK GA VIDVG+NR Sbjct: 181 MLQKGPGANATVTVVHTRTKNMDEHCKRADILIVAAGVPGLVKPEWIKPGACVIDVGVNR 240 Query: 235 L-------ENGKVV----GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 + + K+V GDV F+ A + A ITPVPGGVGPMT+ L+ NTL++ Sbjct: 241 VGEKPSAKDPNKMVAILSGDVDFDAAKEIAGSITPVPGGVGPMTITMLMLNTLKS 295 >UniRef50_P13995 Methenyltetrahydrofolate cyclohydrolase n=52 Tax=cellular organisms RepID=MTDC_HUMAN Length = 350 Score = 239 bits (611), Expect = 6e-62, Method: Compositional matrix adjust. Identities = 139/292 (47%), Positives = 185/292 (63%), Gaps = 15/292 (5%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A +I G+ +AQQ++ EV Q+V+ +A+G + P L+V+LVG NPAS YV +K +A VG Sbjct: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVG 96 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 S + P + SE ELL LI+ LN D+ +DG+LVQLPLP ID ++ + PDKDVDG Sbjct: 97 INSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDG 156 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 FH NVGR+C + P TP G+ +++R I T G N VV G S VG P++M L Sbjct: 157 FHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 216 Query: 183 G--------CTTTVTHRFT--KNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGI 232 G T T++HR+T + L+ H AD++I A G P I D IKEGA VIDVGI Sbjct: 217 GAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGI 276 Query: 233 NRLEN-----GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 NR+ + K+VGDV FE ++A YITPVPGGVGPMTVA L++NT+ A Sbjct: 277 NRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAA 328 >UniRef50_B1GZ24 Bifunctional protein FolD n=2 Tax=Bacteria RepID=B1GZ24_UNCTG Length = 296 Score = 239 bits (611), Expect = 7e-62, Method: Compositional matrix adjust. Identities = 130/283 (45%), Positives = 176/283 (62%), Gaps = 9/283 (3%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 K+IDGK I+ R+E+ ++V + PGLA VLVG +PAS++Y+ SK KACE+ G Sbjct: 2 KLIDGKKISSDKRAEIKEEVAKIKQQTEKIPGLATVLVGGDPASRVYIKSKIKACEDAGI 61 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S ++L +S+ E++ LI LN ++ IDGIL+QLPLP D + L + P KDVDG Sbjct: 62 KSFHHNLDANSSKEEIIALIKKLNENSEIDGILLQLPLPQNKDAQECLNAVSPLKDVDGL 121 Query: 124 HPYNVGRLCQRAPR--------LRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPM 175 HP+N G L L CTP G+V +L + I G AVVIG SN+VG+P+ Sbjct: 122 HPFNAGLLNLSKSWNEIIEKNILVSCTPLGVVHILHKSGIIIEGKTAVVIGRSNLVGKPL 181 Query: 176 SMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL 235 SM LL T + H T+NL+ ++AD+++ AVGK F+ D+IK GA+VIDVGINR Sbjct: 182 SMLLLANNATVIMAHSKTRNLKEICKSADIVVAAVGKSKFVNKDFIKTGAVVIDVGINRT 241 Query: 236 ENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 G + GDV F+ ITPVPGGVGPMT+ L+ENTL+A Sbjct: 242 SEG-LCGDVDFDAVKDMDIKITPVPGGVGPMTITMLLENTLKA 283 >UniRef50_C3K8G7 Putative histidine biosynthesis-related tetrahydrofolate dehydrogenase n=1 Tax=Pseudomonas fluorescens SBW25 RepID=C3K8G7_PSEFS Length = 314 Score = 238 bits (608), Expect = 1e-61, Method: Compositional matrix adjust. Identities = 140/279 (50%), Positives = 183/279 (65%), Gaps = 4/279 (1%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A+ IDGK I+ +V EV ++V +A+ P LAV+LVG +PAS +YV +K ++VG Sbjct: 12 ARDIDGKAISARVLDEVREEV-LLLASQQIYPALAVLLVGDDPASHVYVRNKLLRAKDVG 70 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 S Y LPE S+ ++L+L+ LNAD +++GILVQLPLPA ID V+ I P KDVDG Sbjct: 71 IRSLEYRLPEDASQTQVLDLLAQLNADTSVNGILVQLPLPAQIDEAAVIHAIDPIKDVDG 130 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 FH NVG L Q L PCTP G + LL D GL+AVVIG SNIVG+PM+ LL A Sbjct: 131 FHRENVGGLVQGIEVLTPCTPSGCMRLLHETCGDLSGLHAVVIGRSNIVGKPMATLLLQA 190 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL--ENG-K 239 C+ +V H + + AD+++ AVG+P I W+K GA+VIDVGINR+ E G + Sbjct: 191 NCSVSVVHSRSVDAPALCRLADIVVAAVGRPQLIDARWLKPGAVVIDVGINRITTETGTR 250 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 +VGDV + A AS ITPVPGGVGPMT+A L++NTL A Sbjct: 251 LVGDVDYASARTVASAITPVPGGVGPMTIAYLLKNTLVA 289 >UniRef50_B2S3X1 Methenyltetrahydrofolate cyclohydrolase n=35 Tax=cellular organisms RepID=FOLD_TREPS Length = 315 Score = 238 bits (606), Expect = 2e-61, Method: Compositional matrix adjust. Identities = 133/290 (45%), Positives = 176/290 (60%), Gaps = 9/290 (3%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A++IDGK A + + +A +VQA AA AP LA VLVG +PAS YVA+K++A Sbjct: 1 MDARLIDGKQAAHECTARLATRVQALRAAVGTAPFLAAVLVGDDPASCTYVAAKQRALAR 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 ++ LP S A++LELI LN D + GIL+QLPLPA +D +V + P+KDV Sbjct: 61 AHLRGETHRLPAHASHAQVLELIARLNEDARVHGILIQLPLPAHLDAARVCRAVAPEKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP N G L P PCTP GIV LL R + G V++G S IVGRP+++ L Sbjct: 121 DGFHPLNCGALFLAQPGFVPCTPAGIVHLLRRAQVPLAGARVVIVGRSAIVGRPLAVLLA 180 Query: 181 LAGCTTTVT--HRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 GC TVT H T+ L AD+L+ A+GK FI +++ GA+VIDVGI+ + + Sbjct: 181 SPGCDATVTLCHSHTRGLADICVQADILVAALGKARFIGAPFVRTGAVVIDVGIHHVPDA 240 Query: 239 ------KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 ++ GDV F+ A + ITPVPGGVGPMT+A L+ NTL A EY Sbjct: 241 TAPRGRRLCGDVDFDAVAHKVQAITPVPGGVGPMTIAMLLHNTLCA-AEY 289 >UniRef50_Q1QD30 Methenyltetrahydrofolate cyclohydrolase n=50 Tax=Bacteria RepID=FOLD_PSYCK Length = 298 Score = 237 bits (605), Expect = 3e-61, Method: Compositional matrix adjust. Identities = 125/277 (45%), Positives = 172/277 (62%), Gaps = 1/277 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 +A ++DGK +A+Q+ ++ +V A A R P LA +LVG +PAS YV K AC+ V Sbjct: 13 SATVLDGKALAKQIEQQLRTRVDAIKAKTGRTPSLATILVGDDPASATYVRMKGNACKRV 72 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S ++P T+ AEL+ I LN+ + GIL+Q P+PA ID E+I KDVD Sbjct: 73 GMDSIRVEMPSVTTTAELMAKIYELNSSPDVHGILLQHPVPAHIDERACFEKIDLAKDVD 132 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G GR+ + CTP+GI+ LLE++NI+ GL AVV+G S I+G+PM+M LL Sbjct: 133 GVTCLGFGRMAMQQSAYGSCTPQGIMHLLEQHNIELAGLEAVVVGRSAILGKPMAMMLLN 192 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 A CT T+ H T++L H++ AD+++ AVG P I DWIK GA+VID G + +NG V Sbjct: 193 ANCTVTICHSRTQDLESHIKRADIIVGAVGVPELIKADWIKAGAVVIDAGFHPTDNGG-V 251 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 GD+ + AS TPVPGGVGPMT+ TLI T+ A Sbjct: 252 GDIELQGVENIASAYTPVPGGVGPMTINTLIRQTVDA 288 >UniRef50_Q2SRE7 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=Mollicutes RepID=FOLD_MYCCT Length = 284 Score = 237 bits (604), Expect = 4e-61, Method: Compositional matrix adjust. Identities = 124/275 (45%), Positives = 178/275 (64%), Gaps = 3/275 (1%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+DGK +++ + V Q++ + G R P LAV+L+G++ AS++YV++K KAC VG Sbjct: 3 ILDGKLVSKTRKQLVKQQIDIYLNKGYRKPKLAVILIGNDQASELYVSNKIKACNLVGIE 62 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S E + L + I+ LN D +D IL+QLPLP ++ L+ I P KDVDGFH Sbjct: 63 SMLLRFDENINSQTLSDQINQLNNDQLVDAILLQLPLPKHLNEQMFLQAITPLKDVDGFH 122 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 N G++ + + PCTP GI+ LL+ YN+D + +IG SNIVG+P+++ L G Sbjct: 123 YINQGKMLEGYDTIYPCTPIGIINLLKAYNVDVKSKDITIIGTSNIVGKPLAIMLSNMGA 182 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINR--LENGKVVG 242 T ++ ++ TK+L+ + + +D++I A GK I D IK+ AIVIDVGI R + N K+VG Sbjct: 183 TVSMCNKNTKSLKKYTKISDIVISATGKQFIITKDMIKKNAIVIDVGIIRDPITN-KIVG 241 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 DV FE+ + SYITPVPGGVGPMTVA L+ENTLQ Sbjct: 242 DVDFENVKELCSYITPVPGGVGPMTVAMLLENTLQ 276 >UniRef50_B0TFC9 Methenyltetrahydrofolate cyclohydrolase n=7 Tax=Clostridia RepID=FOLD_HELMI Length = 287 Score = 235 bits (599), Expect = 2e-60, Method: Compositional matrix adjust. Identities = 131/276 (47%), Positives = 166/276 (60%), Gaps = 1/276 (0%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A+ IDGK IA Q+R+E+ +V + G+ P LAV+LVG +PAS +Y SK KA Sbjct: 1 MTAQYIDGKAIAAQLRAEIKAEVASLREQGI-VPKLAVILVGDDPASVVYARSKEKAAAN 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G + LP T+EA LL LI+ LNAD + GI+V+LPLP I KVLE IHP KDV Sbjct: 60 LGIAFELFTLPGDTTEAALLALIERLNADAAVHGIMVELPLPKQISKEKVLEAIHPLKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG HP N G L P L P TP + LL R ++ G V+IG VG+P+ LL Sbjct: 120 DGVHPLNRGYLMAGQPGLVPATPMSCMELLARSGVELAGKRVVIIGRGETVGKPLFFLLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T TV H TK+L V A+++I A GK G + G+ I A+VID GIN E+G + Sbjct: 180 RRNATVTVCHTRTKDLAAEVRRAEIVIAAAGKAGLVTGEMIAPDAVVIDAGINEGEDGNI 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 VGDV +AA+RAS I+PVPGGVG T A L N L Sbjct: 240 VGDVKTAEAAERASLISPVPGGVGACTTALLFRNVL 275 >UniRef50_C8P9U1 Putative uncharacterized protein folD2 n=1 Tax=Lactobacillus antri DSM 16041 RepID=C8P9U1_9LACO Length = 289 Score = 233 bits (595), Expect = 5e-60, Method: Compositional matrix adjust. Identities = 125/275 (45%), Positives = 173/275 (62%), Gaps = 3/275 (1%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 IIDGK IA+++ ++ Q+V A A L PG+AV++VG +PASQIY +K + +++G Sbjct: 2 IIDGKKIAREINAKTRQQVAALKAHQL-TPGIAVIVVGDDPASQIYTRTKHRLAQKLGIA 60 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S Y P +A +L+ + LN D+++D ILVQ PLPA ++ +++ I P KD DG H Sbjct: 61 STRYHFPADVDQATVLQQVRKLNRDDSVDAILVQAPLPAQLNGEEIVNAIDPAKDADGLH 120 Query: 125 PYNVGRLCQRAPRLRP--CTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 P N+GRL + P CTPRGI+TLL++Y + G N V++G S +VG+P+ L Sbjct: 121 PLNLGRLYAKQGGHYPVACTPRGIMTLLKQYQVPLAGANVVIVGRSLLVGKPLLALLNNQ 180 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T T R TK AD+LIVA G PG + +K GA+VIDVGINRL +GK+VG Sbjct: 181 NATVTFVGRHTKKRATLTRQADILIVAAGVPGLVKAGDVKAGAVVIDVGINRLPSGKLVG 240 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 DV F A A ITPVPGGVGP+TVA L+ T++ Sbjct: 241 DVDFAGVASLARLITPVPGGVGPLTVAMLMRQTVE 275 >UniRef50_A6LU44 Methenyltetrahydrofolate cyclohydrolase n=22 Tax=Clostridium RepID=FOLD_CLOB8 Length = 282 Score = 233 bits (593), Expect = 7e-60, Method: Compositional matrix adjust. Identities = 117/279 (41%), Positives = 172/279 (61%), Gaps = 1/279 (0%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 +II+GK +A +V+ E+ V R L+ P +A +LVG++ S Y+ S+ K +G Sbjct: 2 GQIINGKEVALKVKEEIKNFVNNRKEKNLQVPKIASILVGNDGGSIYYMGSQEKVANSLG 61 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 LPET ++ +++ I+ LN DN I GI++QLPLP D K++++I P+KD+D Sbjct: 62 VEFLKLTLPETCNDEDVIAEINKLNEDNNIHGIILQLPLPNNFDEKKIIKQISPNKDIDC 121 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 + G+L P+ PCTP ++TL++ NID G N VV+G SNIVG+P++ LL Sbjct: 122 LTFESQGKLYMGEPKFLPCTPNSVITLIKSLNIDIVGKNVVVLGRSNIVGKPVAQLLLNE 181 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T T+ H TKNLR +NAD+L+VA+G+P FI ++ E AIVIDVG + E GK+ G Sbjct: 182 NATVTICHSKTKNLREVCKNADILVVAIGRPKFIDETYVNENAIVIDVGTSSFE-GKITG 240 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 DV F+ + Y+TPVPGGVG +T LI+N +A E Sbjct: 241 DVDFDKVIDKCRYLTPVPGGVGSLTTTLLIKNACEALQE 279 >UniRef50_B8C1N0 5, 10-methylenetetrahydrofolate dehydrogenase n=1 Tax=Thalassiosira pseudonana RepID=B8C1N0_THAPS Length = 316 Score = 231 bits (589), Expect = 2e-59, Method: Compositional matrix adjust. Identities = 130/306 (42%), Positives = 180/306 (58%), Gaps = 28/306 (9%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A+ IDGK+IA +RSE+A ++ + + PGLAV+LVGS SQ YV K+KAC + Sbjct: 1 MTAQDIDGKSIAATIRSELAAELSSLPSDSTSRPGLAVMLVGSRKDSQTYVRMKQKACSD 60 Query: 61 VGFVSRSYDLP--ETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDK 118 G VS + P E E LL+ I N D + GILVQLPLP I ++L+ + P K Sbjct: 61 CGMVSFLQEYPNGEEVEEEMLLKKIREWNEDEKVHGILVQLPLPEKISEERILKAVDPKK 120 Query: 119 DVDGFHPYNVGRLCQRA----------------PRLRPCTPRGIVTLLERYN----IDTF 158 DVDG HP N L + P PCTP+G + LL+R N ++ Sbjct: 121 DVDGLHPANTASLFSTSTHAGAQKLNWKDFTSIPFHIPCTPQGCIELLDRINDGKGVEIE 180 Query: 159 GLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPG 218 G+NAVVIG SN+VG P++M LL T T+ H TKN+ + V+ AD+++ AVG+ +P Sbjct: 181 GMNAVVIGRSNLVGLPVAMLLLHRNATVTIVHSRTKNIENVVKQADIVVAAVGRANMVPA 240 Query: 219 DWIKEGAIVIDVGINRLE------NGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLI 272 W+K G VIDVGIN ++ ++VGDV + +A + +ITPVPGGVGP+T+A L+ Sbjct: 241 SWLKPGCTVIDVGINSVDAPDTKRGYRLVGDVNYAEAKEVCGWITPVPGGVGPLTIAMLL 300 Query: 273 ENTLQA 278 NTL + Sbjct: 301 RNTLNS 306 >UniRef50_Q9H903 Methenyltetrahydrofolate cyclohydrolase n=75 Tax=cellular organisms RepID=MTD2L_HUMAN Length = 289 Score = 230 bits (586), Expect = 5e-59, Method: Compositional matrix adjust. Identities = 128/284 (45%), Positives = 173/284 (60%), Gaps = 15/284 (5%) Query: 11 IAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDL 70 +A+ ++ E+ + V++ ++ G R P L+++LVG NPAS YV +K +A VG S Sbjct: 1 MAKHIQKEIQRGVESWVSLGNRRPHLSIILVGDNPASHTYVRNKIRAASAVGICSELILK 60 Query: 71 PETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGR 130 P+ S+ ELL++ D LN D + GILVQLPLP +D + I P+KDVDGFH N+GR Sbjct: 61 PKDVSQEELLDVTDQLNMDPRVSGILVQLPLPDHVDERTICNGIAPEKDVDGFHIINIGR 120 Query: 131 LCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG------- 183 LC L P T + +++R I TFG N VV G S VG P++M L G Sbjct: 121 LCLDQHSLIPATASAVWEIIKRTGIQTFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGG 180 Query: 184 -CTTTVTHRFT--KNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN--- 237 T T+ HR+T + L+ H + AD++IVA G P I D +KEGA VIDVGIN + + Sbjct: 181 DATVTIAHRYTPKEQLKIHTQLADIIIVAAGIPKLITSDMVKEGAAVIDVGINYVHDPVT 240 Query: 238 --GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 K+VGDV FE K+A +ITPVPGGVGPMTVA L++NTL A Sbjct: 241 GKTKLVGDVDFEAVKKKAGFITPVPGGVGPMTVAMLLKNTLLAA 284 >UniRef50_B0S8U6 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=Bacteria RepID=FOLD_LEPBA Length = 291 Score = 230 bits (586), Expect = 5e-59, Method: Compositional matrix adjust. Identities = 122/284 (42%), Positives = 177/284 (62%), Gaps = 4/284 (1%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 ++DGK I++++R+ + + + A G P LA +LVG+NPAS+ YV K KACE+VG Sbjct: 6 LLDGKAISEKIRNRIQETLAKAKAEGKGIPTLATILVGNNPASETYVNMKVKACEKVGMH 65 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 SR L E T+ ELL I LN D +I+GIL+Q P+P ID K + I +KDVDG Sbjct: 66 SRYIRLKEETTTEELLGEIRKLNLDPSINGILLQHPVPHQIDERKAFDEIALEKDVDGVT 125 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 + G+L + PCTP G+V LL+ Y ID G +AVV+G S I+G+PM++ L Sbjct: 126 TISFGKLSMNSEAYYPCTPYGMVLLLQEYGIDVTGKHAVVVGRSPILGKPMAIMLTNLNA 185 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+ H T++L V+ AD+++ AVGKP FI +W+KEG +++D G N + N VGD+ Sbjct: 186 TVTLCHSKTEDLPSLVKQADIIVGAVGKPEFIKAEWMKEGVVILDAGYN-VGN---VGDI 241 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQDE 288 A ++SY TPVPGGVGPMT++ L+ T+ + + P+ E Sbjct: 242 EVSKAKDKSSYYTPVPGGVGPMTISVLLLQTMYSFLGQFSPKLE 285 >UniRef50_A8GNK0 Methenyltetrahydrofolate cyclohydrolase n=15 Tax=cellular organisms RepID=FOLD_RICAH Length = 295 Score = 229 bits (585), Expect = 7e-59, Method: Compositional matrix adjust. Identities = 119/281 (42%), Positives = 172/281 (61%), Gaps = 7/281 (2%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 IIDGK +A ++ ++ ++Q + +P LA+VLVG NPAS IYV +K K ++G Sbjct: 4 IIDGKALANEILEDLKLEIQELKSQTNASPKLAIVLVGDNPASIIYVKNKIKNAHKIGID 63 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + +L T +L+ I+ LN DN I G++VQLPLP ID K+L + P KDVDGFH Sbjct: 64 TLLVNLSTTIHTNDLITKINELNHDNEISGMIVQLPLPNSIDKNKILSAVSPYKDVDGFH 123 Query: 125 PYNVGRL-------CQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSM 177 P NVG L + + PCT G + ++++Y + G + VVIG SNIVG+P+S Sbjct: 124 PLNVGYLHSGIIDVSEFSQSFIPCTALGCLAVIKKYEPNLSGKHVVVIGRSNIVGKPLSA 183 Query: 178 ELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 LL C+ T+ H T NL AD+++ A+G P + ++ +IVIDVGINR+ Sbjct: 184 LLLKEDCSVTICHSKTHNLGSIALKADIVVAAIGSPLKLTAEYFNPESIVIDVGINRISG 243 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 K++GDV FE + YITPVPGG+GPMT+A L++NT++A Sbjct: 244 NKIIGDVDFEHVKSKVKYITPVPGGIGPMTIAFLLKNTVKA 284 >UniRef50_A5V1H2 Methenyltetrahydrofolate cyclohydrolase n=7 Tax=Bacteria RepID=FOLD_ROSS1 Length = 288 Score = 228 bits (581), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 131/279 (46%), Positives = 174/279 (62%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A I+DG+ +A+ +R E+ QA I AP LAVV + +PAS Y + RK CEE Sbjct: 1 MTAIILDGRALAKTLREELRADTQAFIQNNGIAPSLAVVKIAGDPASDRYTRTIRKGCEE 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G + LP T++A L E I L+ D TI GIL+ LPLP G+D+ + + +I P KDV Sbjct: 61 IGITFTDHTLPPETTQAMLEETISALSFDRTIHGILLHLPLPPGLDSARAIAQIDPAKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG HPYN G L P L P TP G + LL R NI G +A V+G S +VG+PM++ LL Sbjct: 121 DGVHPYNAGLLAMGRPGLIPNTPAGGMELLLRNNIPLKGQHATVVGRSVVVGKPMALLLL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T T+ H TK+L V +AD+++ A GKPG I GD +K GA+V+D G+N LE+G+V Sbjct: 181 NEHATVTIAHSRTKDLAAVVRSADIVVAATGKPGLITGDMVKPGAVVVDFGVNVLEDGRV 240 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 VGDV F+ AS ITPVPGG GP+T L+ N L+A Sbjct: 241 VGDVDFDSVVNVASAITPVPGGTGPVTNVMLLRNVLRAA 279 >UniRef50_D0MY89 Bifunctional folD protein n=1 Tax=Phytophthora infestans T30-4 RepID=D0MY89_PHYIN Length = 307 Score = 228 bits (580), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 125/294 (42%), Positives = 178/294 (60%), Gaps = 16/294 (5%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 MAA++IDGK IA+ +R+ + V A A RAP L +++VG S +YV +K AC Sbjct: 1 MAARLIDGKAIAKALRAALKGDVAALTAKHGRAPALGLIMVGDRKDSALYVRNKNTACRR 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVK-VLERIHPDKD 119 G S ++ E S+ +++ ++ LN D +IDGILVQLPLP N + +++RI DKD Sbjct: 61 TGIRSENFLFDEGVSQDTIVQKVEELNEDPSIDGILVQLPLPGTQLNAQQIIDRIQHDKD 120 Query: 120 VDGFHPYNVGRLCQRA--PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSM 177 VDG HP+N G L R P L PCT +GI+ LL+ + G AV+IG SN+VG P+SM Sbjct: 121 VDGLHPFNAGELAMRGRYPYLIPCTAKGILALLDEQHTPLRGKTAVIIGRSNLVGNPVSM 180 Query: 178 ELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 L TT + H T +L +V AD+++ A G+P + G+W+K GA V+DVGIN + + Sbjct: 181 LLQKRDATTILCHSKTVDLPRYVRQADVVVAACGQPYLVRGEWLKPGATVVDVGINFVRD 240 Query: 238 -------------GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 K+VGDV F +A + A +TPVPGGVGPMT+A L+ N ++A Sbjct: 241 VDGEFHGEANADGFKLVGDVNFHEACEVAGALTPVPGGVGPMTIAMLLHNVVEA 294 >UniRef50_C0R292 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=Brachyspira RepID=FOLD_BRAHW Length = 281 Score = 225 bits (573), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 112/274 (40%), Positives = 172/274 (62%), Gaps = 4/274 (1%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 + I+DG+ +A++++ + ++ + + P + + + ++++Y +K E VG Sbjct: 2 SNILDGRELAKEIKERIKKETEIL----EKKPRIDFLYFEDDKSTEVYFTRAKKQAESVG 57 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 + ++LP T+E + L LI+ LN ++ GI++Q+PLP I KV E I +KD D Sbjct: 58 MIGSLHNLPVNTTEKDFLTLIEYLNEESETSGIMIQMPLPKHISKKKVYETISIEKDADA 117 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 N+GR+ L PCT + + L+E+ I+ G NAVVIG S IVG+P++ LL Sbjct: 118 ISHVNLGRIFIGDSNLAPCTAKSAMALIEKSGINIEGANAVVIGRSEIVGKPLAHLLLQK 177 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T T+ H TKNL+ +NAD+L V++GK FI G++IKEGA+VIDVGIN LE+G + G Sbjct: 178 SATVTIAHSKTKNLKELCKNADILCVSIGKAEFITGEYIKEGAVVIDVGINVLEDGSLKG 237 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 DV FE+A+K ASYITPVP GVG +TV+ L++N L Sbjct: 238 DVNFEEASKLASYITPVPNGVGSVTVSMLLDNVL 271 >UniRef50_A8IFV5 5,10-methylenetetrahydrofolate dehydrogenase (Fragment) n=1 Tax=Chlamydomonas reinhardtii RepID=A8IFV5_CHLRE Length = 301 Score = 224 bits (572), Expect = 2e-57, Method: Compositional matrix adjust. Identities = 128/292 (43%), Positives = 179/292 (61%), Gaps = 17/292 (5%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGL-RAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A I+DG+ +A E+ V AR+ L R PGL VVLVGS P S +YV K++AC++ Sbjct: 1 AVILDGRAVAAAWERELVGDV-ARLTELLGRPPGLGVVLVGSRPDSMLYVTKKQEACQKA 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + + LP+T S+++L + + AD +DG+L+QLPLP + V+E + P KDVD Sbjct: 60 GMNTYVHHLPDTVSQSQLEAALAHVCADGRVDGVLIQLPLPRHLSEEAVMEVLDPRKDVD 119 Query: 122 GFHPYNVGRLCQRAP--RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 GFHP N+GR+ R RL P TP G + LL R +D G N VV+G SNIVG P++ L Sbjct: 120 GFHPLNMGRMLMRGRGVRLVPATPLGCIELLRRSGVDVQGKNCVVLGDSNIVGTPLAAML 179 Query: 180 LLAGCTT-TVTHRF-------TKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVG 231 G T+ HR + L +AD+L+VAVG P + GDW++ GA+VIDVG Sbjct: 180 RDKGAAAVTICHRRSYRECFQSYQLPDLTRSADILVVAVGHPELVRGDWVRPGAVVIDVG 239 Query: 232 INRLEN-----GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 IN + +VVGDV F++ ++ A ITPVPGG+GPMT+A ++ NTL+A Sbjct: 240 INVVSTLPRSPPRVVGDVAFDEVSRVAGAITPVPGGIGPMTIAAVLHNTLKA 291 >UniRef50_Q2GLF2 Methenyltetrahydrofolate cyclohydrolase n=41 Tax=Bacteria RepID=FOLD_ANAPZ Length = 304 Score = 223 bits (567), Expect = 7e-57, Method: Compositional matrix adjust. Identities = 119/280 (42%), Positives = 171/280 (61%), Gaps = 5/280 (1%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 IIDGK A + + ++ P L V++VG +PAS++YV +K++ EE+G Sbjct: 8 IIDGKAAAADLLGRLKVVMEGLKEEHGLFPSLVVIIVGDDPASRLYVGNKQRKAEELGIN 67 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S++ LP T++ ELL +I LN D + GILVQLPLP ID + ++ I P+KDVDGFH Sbjct: 68 SKTIALPYETTQEELLGIIQELNEDENVHGILVQLPLPKHIDKILIINAIDPEKDVDGFH 127 Query: 125 PYNVGRLCQ-RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 N G+L + PCTP+G + L+++ AVVIG SNIVG+P+++ L+ Sbjct: 128 NANAGKLLTGEMDCMVPCTPQGCIYLIKKVMPVLSSKRAVVIGRSNIVGKPVALLLMYEN 187 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL---ENGKV 240 CT ++ H T N+ H +A+++I AVGK + +W+ GA+VIDVGIN + + Sbjct: 188 CTVSILHSATANIEEHCRDAEIIIAAVGKARMVKSEWVSPGAVVIDVGINLITSESKNRF 247 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENT-LQAC 279 VGDV FE + + ITPVPGGVGPMT+A L+ NT L AC Sbjct: 248 VGDVDFESVRDKVAAITPVPGGVGPMTIAFLLVNTVLGAC 287 >UniRef50_P11586 Formyltetrahydrofolate synthetase n=378 Tax=root RepID=C1TC_HUMAN Length = 935 Score = 221 bits (562), Expect = 3e-56, Method: Compositional matrix adjust. Identities = 125/291 (42%), Positives = 181/291 (62%), Gaps = 11/291 (3%) Query: 3 AKIIDGKTIAQQVRSEVAQKV-QARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A+I++GK I+ Q+R+ + +V Q + P LA++ VG+ S +Y+ K KA EE+ Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPA--GIDNVKVLERIHPDKD 119 G + LP TT+E+E+++ I +LN D+T+ G LVQLPL + I+ +V+ I P+KD Sbjct: 64 GIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKD 123 Query: 120 VDGFHPYNVGRLCQRAPR--LRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSM 177 VDG N GRL + PCTP+G + L++ + G +AVV+G S IVG PM Sbjct: 124 VDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHD 183 Query: 178 ELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGIN---- 233 LL T T H T +L V D+L+VA G+P + G+WIK GAIVID GIN Sbjct: 184 LLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYVPD 243 Query: 234 -RLENG-KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 + NG KVVGDV +++A +RAS+ITPVPGGVGPMTVA L+++T+++ + Sbjct: 244 DKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRF 294 >UniRef50_D0N1V3 Bifunctional folD protein n=1 Tax=Phytophthora infestans T30-4 RepID=D0N1V3_PHYIN Length = 308 Score = 220 bits (560), Expect = 5e-56, Method: Compositional matrix adjust. Identities = 131/297 (44%), Positives = 175/297 (58%), Gaps = 21/297 (7%) Query: 5 IIDGKTIAQQVRSEVA-QKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 ++DGK + + +++ Q V + G R+ GLAV++VGS S YV K+KAC VG Sbjct: 9 LLDGKATSDAICTQLQPQCVDFKQRYG-RSVGLAVMVVGSRKDSATYVRMKQKACTAVGI 67 Query: 64 VSRSY-----DLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDK 118 S D P+ + +ELL +I LN +DGI+VQLPLP+ D +L I P+K Sbjct: 68 TSWKIAIALDDKPQESVTSELLAIIKQLNNREDVDGIIVQLPLPSFCDESAILATIAPNK 127 Query: 119 DVDGFHPYNVGRLCQRA-------PRLR-PCTPRGIVTLLERYNIDTFGLNAVVIGASNI 170 DVDG HP + +L Q A P PCTP G + LL+ Y I G + VV+G S I Sbjct: 128 DVDGLHPESHAKLFQYATTKAQLVPSFALPCTPAGCLELLDHYKIPLEGKHVVVMGRSQI 187 Query: 171 VGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDV 230 VG P+S+ L T T+ H T++L+ V AD++I A+G+P F+ GDWIK GA VIDV Sbjct: 188 VGLPVSLLCLHRNATVTMCHSHTRDLKARVLEADIVIAAIGRPCFVQGDWIKPGATVIDV 247 Query: 231 GINRLENG------KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 GIN LE+ ++VGDV F A K ITPVPGGVGPMTVA L++NTLQ + Sbjct: 248 GINPLEDATKKSGYRLVGDVDFNAAVKVVHAITPVPGGVGPMTVAMLLKNTLQCAIR 304 >UniRef50_D0N1T3 Bifunctional folD protein n=1 Tax=Phytophthora infestans T30-4 RepID=D0N1T3_PHYIN Length = 298 Score = 220 bits (560), Expect = 6e-56, Method: Compositional matrix adjust. Identities = 121/297 (40%), Positives = 184/297 (61%), Gaps = 22/297 (7%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 AK++DGK ++++ +E+ + V P LA++LVG++ S+ YV K+ AC VG Sbjct: 2 AKLLDGKACSKEIEAELKELVPTLNVT----PTLALLLVGTDQDSKTYVRLKKNACTRVG 57 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLP--AGIDNVKVLERIHPDKDV 120 + ++L E+ AELL LI +LNADN++ GIL+QLPLP + ++LE + P KDV Sbjct: 58 ITPQVHELAESIEFAELLALIQSLNADNSVHGILLQLPLPDHLKLHEEELLEAVSPLKDV 117 Query: 121 DGFHPYNVGRLCQ---------RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIV 171 DG H ++ RL + + +L+PCTP G + +L R I+ G + VVIG +V Sbjct: 118 DGLHSHHFARLAEPEKEEEGAVKTLQLQPCTPAGCLEILARNGIELAGKDVVVIGRGQLV 177 Query: 172 GRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVG 231 G P+S+ LL A T T H TKNL V A+++ V G+P + GDW+ EGA+V+DVG Sbjct: 178 GLPLSLMLLAANATVTTCHSKTKNLADKVRQAEVVFVGTGQPELVKGDWLAEGAVVVDVG 237 Query: 232 INRLENG------KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 I+ +++ K++GDV F A++R S ITPVPGG+GPMT+A L++NT++ C + Sbjct: 238 ISYVDDASSKKGYKILGDVDFAAASERVSAITPVPGGIGPMTIAMLLKNTVE-CATF 293 >UniRef50_UPI0000DB7ABF PREDICTED: similar to Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor n=1 Tax=Apis mellifera RepID=UPI0000DB7ABF Length = 407 Score = 218 bits (555), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 132/297 (44%), Positives = 179/297 (60%), Gaps = 17/297 (5%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A IIDGK IA ++++E+ V I + P L + VG+NPAS+IYV K KA +G Sbjct: 110 AIIIDGKKIANKIQNELKITVDNWINDNKKRPKLVAIKVGNNPASKIYVEKKIKAANFIG 169 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 + + L E +S+ +++ ID LN D T+DGILVQLPL ++ +V + I P KDVDG Sbjct: 170 IENYTIHLDEKSSQQDIINEIDNLNKDKTVDGILVQLPLIKHMNEQEVCQAIIPSKDVDG 229 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 FH N+G L + P T + L+ R NI+TFG NAVV+G S VG P++ LLL Sbjct: 230 FHLENLGNLALNRNGIIPATALAVKELIIRNNIETFGKNAVVVGRSKHVGLPIA--LLLH 287 Query: 183 G----------CTTTVTHRFTKN--LRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDV 230 G TTT+ HR T + L + ADL++VA G PG I + IK GA +IDV Sbjct: 288 GDSKDRTGALDMTTTICHRHTPHTELEKFTKLADLVVVAAGIPGLITKEMIKPGACIIDV 347 Query: 231 GINRLE---NGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 GI R++ K+VGDV FE+ A YITPVPGGVGPMTVA L++NT+ A + ++ Sbjct: 348 GITRIKMDNKYKIVGDVDFENVKSIAGYITPVPGGVGPMTVAMLMKNTILAANKNYE 404 >UniRef50_B1ZYH0 Methenyltetrahydrofolate cyclohydrolase n=8 Tax=root RepID=FOLD_OPITP Length = 293 Score = 217 bits (553), Expect = 3e-55, Method: Compositional matrix adjust. Identities = 125/285 (43%), Positives = 173/285 (60%), Gaps = 14/285 (4%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 +IDG IA + +E+ +V A R P +A+V +G +PAS YV +K + E+G Sbjct: 3 LIDGSKIAATIVAELKAEVAALTG---RKPCIALVRIGEDPASVSYVKNKERTAAEIGLT 59 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 R P T S+AEL LID LNAD +DGILVQ P+P +D ++V RI P+KDVDG Sbjct: 60 GRVILPPVTISQAELFALIDGLNADAGVDGILVQAPMPKHLDELQVFRRIAPEKDVDGLG 119 Query: 125 PYNVGRLCQRAPR-LRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL-- 181 N+G++ Q CTP GI+ LL R +D G + VV+G S +VG+P+++ L Sbjct: 120 TMNLGKVAQDDDTGFVSCTPAGIMELLSRSGVDLKGKHVVVVGRSLLVGKPVALLALQKK 179 Query: 182 --AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG- 238 A T T+ H TK+L AD+LI A+G+ GF+ D +K G +VIDVGINR+ + Sbjct: 180 AGANGTVTICHSATKDLPAITRQADVLIAAIGRAGFVTADMVKPGVVVIDVGINRVPDST 239 Query: 239 -----KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 ++VGDV F + AS ITPVPGGVGPMTVA L++NT++A Sbjct: 240 KKSGYRLVGDVDFPAVSPLASQITPVPGGVGPMTVAMLMKNTVKA 284 >UniRef50_Q7TU81 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Prochlorococcus marinus subsp. pastoris str. CCMP1986 RepID=FOLD_PROMP Length = 298 Score = 217 bits (553), Expect = 3e-55, Method: Compositional matrix adjust. Identities = 117/276 (42%), Positives = 170/276 (61%), Gaps = 5/276 (1%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 +DGK ++ ++ + + R PGLAV+ +G +PAS +YV +K KAC VG S Sbjct: 5 LDGKKLSLEIEERLRNYILTNKTIAKRNPGLAVIRIGEDPASGVYVGNKEKACSRVGIKS 64 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 + L +T + E+ +L++ LN DN IDG+L+QLP+ D +++ I+P+KDVDG + Sbjct: 65 YIFHLKDTVEQKEVEQLLNKLNLDNNIDGMLLQLPISKKFDEQRLISFINPEKDVDGLNE 124 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCT 185 N+G+L + +R CTP GIV LL+ NI G VVIG S +VG+P+S+ +L T Sbjct: 125 QNIGKLVKNEQAMRSCTPAGIVNLLKSQNIKIEGKKIVVIGRSLLVGKPLSLMMLNLNAT 184 Query: 186 TTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-----KV 240 T+TH T NL + AD+LI A GKP I ++KEGA++IDVGI+RL + ++ Sbjct: 185 VTITHSKTINLNKICKEADILIAAAGKPNLINSSFVKEGAVIIDVGIHRLTSSDKSKTRL 244 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 GDV+ ED + TPVPGGVGPMTV L+ NT+ Sbjct: 245 CGDVLLEDVIPKVFAYTPVPGGVGPMTVTMLLVNTI 280 >UniRef50_C5BI30 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=Bacteria RepID=FOLD_TERTT Length = 280 Score = 217 bits (552), Expect = 4e-55, Method: Compositional matrix adjust. Identities = 122/278 (43%), Positives = 169/278 (60%), Gaps = 4/278 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M+A I+DGK +AQ+ +E++++V A + R P LA +LVG +PAS YV K AC Sbjct: 1 MSALILDGKALAQKTEAELSERVAALKSKTGRTPILATILVGGDPASATYVRMKGNACTR 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G S +LPETT+ ELL I LN + + GIL+Q P+P+ ID + I KDV Sbjct: 61 IGMDSMKVELPETTTTDELLAKIAELNNNPDVHGILLQHPVPSQIDERACFDAIDLSKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG GR+ TP+GI+ LLE Y I G +AVV+G S I+G+PM++ LL Sbjct: 121 DGVTCLGFGRMAMGEEAYGCATPKGIMRLLEAYEIPLEGKHAVVVGRSPILGKPMALMLL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 A T T+ H TK+L+ H+ AD+++ AVG P FI DWIK GA+V+D G + G Sbjct: 181 NANATVTICHSRTKDLQSHIATADIVVGAVGIPEFIKADWIKPGAVVVDAGYH--PGG-- 236 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 VGD+ A +AS +TPVPGGVGPMT+ TLI ++ + Sbjct: 237 VGDIELGPLADKASALTPVPGGVGPMTINTLIYQSVDS 274 >UniRef50_C8PD95 Putative uncharacterized protein folD n=1 Tax=Lactobacillus iners DSM 13335 RepID=C8PD95_9LACO Length = 301 Score = 212 bits (539), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 114/272 (41%), Positives = 171/272 (62%), Gaps = 2/272 (0%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+DGK A+++ E+ +V+ A + P V+ VG +PAS+IY+ KRK +++G Sbjct: 21 ILDGKEPAKKIIDELTLEVEHLKAKNI-LPTFCVIEVGEDPASKIYLRLKRKLAKKIGIN 79 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 ++ P + EL++ I LNAD +D I+VQLP+P I+ VLE I P KD DGF Sbjct: 80 EQTIKFPGDIRQDELIDKIKELNADPHVDAIMVQLPIPEHINTRLVLEAIDPTKDADGFT 139 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 PYN GR+ Q + P T R I+T+L+ Y ++ G NA++IG S IVG+P++ +LL Sbjct: 140 PYNQGRMWQGQVNIIPATVRSIMTILDYYQLNVEGKNALIIGRSIIVGKPVASQLLARNA 199 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+ H T+NL+ D++I VG+ I + +K G+I+IDVG+NR ENGK++GD+ Sbjct: 200 TVTIAHSHTRNLQELTLLNDIIISDVGRAHLITKNMVKPGSILIDVGMNR-ENGKLMGDI 258 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 ++D A ITPVPGGVGP+TVA L++ + Sbjct: 259 EYDDCLPIAEAITPVPGGVGPLTVANLMKQVI 290 >UniRef50_D1ITY4 Whole genome shotgun sequence of line PN40024, scaffold_5.assembly12x (Fragment) n=1 Tax=Vitis vinifera RepID=D1ITY4_VITVI Length = 271 Score = 212 bits (539), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 127/282 (45%), Positives = 162/282 (57%), Gaps = 44/282 (15%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A IIDGK IAQ +RSE+A++V+ + PGLAVV+VG+ SQ YV+ KRKAC EVG Sbjct: 9 ASIIDGKAIAQAIRSEIAEEVRHLSEKYGKVPGLAVVIVGNRKDSQSYVSMKRKACAEVG 68 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 S DLPE E+EL+ + LNA + GILVQLPLP I+ KVL I +KDVDG Sbjct: 69 IKSFDVDLPEQVLESELIGKVHELNALPDVHGILVQLPLPKHINEEKVLSEISLEKDVDG 128 Query: 123 FHPYNVGRLCQ--RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 FHP N+G+L R P PCTP+G + LL R I V P S+ Sbjct: 129 FHPLNIGKLAMKGREPLFLPCTPKGCLELLSRSGIS--------------VKDPESI--- 171 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-- 238 + +AD++I A G+ I G WIK GA VIDVG N + + Sbjct: 172 -------------------IRDADIVIAAAGQAMMIKGSWIKPGAAVIDVGTNAVNDPSK 212 Query: 239 ----KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 ++VGDV F++A K A ++TPVPGGVGPMTVA L++NTL Sbjct: 213 KSGYRLVGDVDFQEACKVAGWVTPVPGGVGPMTVAMLLKNTL 254 >UniRef50_C9LM47 Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase n=1 Tax=Dialister invisus DSM 15470 RepID=C9LM47_9FIRM Length = 281 Score = 211 bits (536), Expect = 3e-53, Method: Compositional matrix adjust. Identities = 114/274 (41%), Positives = 163/274 (59%), Gaps = 2/274 (0%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+DGK A + ++ +++ G LAV+L GS+ S +Y +KA G Sbjct: 2 ILDGKVTAAALEKDIRERIDVLKERGCTLK-LAVILAGSSKPSHMYAEFMKKAALSYGIG 60 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + Y+ PE E EL LI LN + +I GIL+ +PLP I K++E IHPDKD+DG Sbjct: 61 TELYEKPENVKEDELGALIQALNGNPSITGILMMMPLPGHIHEEKMIEMIHPDKDMDGLT 120 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 N GRL L TPR ++ +L+ Y I G +AV+IG SN++G+P++M L+ Sbjct: 121 TVNAGRLFSGKDGLFGGTPRAVMAILKHYGISVEGKHAVIIGRSNVIGKPVAMMLMQKNA 180 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+ H TKNL + AD+L+ AVGK G + D +K GAIV+DVGINR+ +GK VGDV Sbjct: 181 TVTICHSRTKNLSEITQQADILVTAVGKAGCVTADMVKPGAIVLDVGINRI-HGKTVGDV 239 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 +E+ A +TPVPGGVG +T +IE+ ++A Sbjct: 240 DYENVFPVAGAVTPVPGGVGSVTTTMIIESIVKA 273 >UniRef50_D1CB15 Methylenetetrahydrofolate dehydrogenase (NADP(+)) n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CB15_THET1 Length = 285 Score = 208 bits (530), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 105/274 (38%), Positives = 167/274 (60%), Gaps = 1/274 (0%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 I+DGK +A+ +R ++ ++QA + P LAVVL P + +Y + +K +++G Sbjct: 7 NILDGKAVAKTIRQQLESQIQAFQTSRGYVPNLAVVLPSEEPDACLYAQNLQKWFQKLGL 66 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + L + ++ +L I +L + + G+++Q+PLP G+ + V E + P KDV+G Sbjct: 67 GCFVHQLSSSITQEDLCAYIRSLCSSADVHGVMIQMPLPDGVSYLSVAEALDPMKDVEGI 126 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 HPYN G L P++ P TP TL++ Y ID G N VVIG SN+VG+P + +L+ Sbjct: 127 HPYNFGLLSIGNPQVVPSTPMAAATLIDHYGIDVSGKNVVVIGRSNVVGKPFAQLMLMKH 186 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 + +V H +K++R + NAD++ VAVG+P + D ++EG IVID GIN + N ++VGD Sbjct: 187 ASVSVLHSRSKSIRDYTLNADIVAVAVGRPNTLTADMVREGVIVIDFGINFV-NDRLVGD 245 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 V FE + AS+ITPVPGG+GP+T L N ++ Sbjct: 246 VDFEAVSPLASFITPVPGGIGPLTNLMLASNLIK 279 >UniRef50_Q254F7 Methenyltetrahydrofolate cyclohydrolase n=13 Tax=Chlamydiaceae RepID=FOLD_CHLFF Length = 287 Score = 207 bits (528), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 112/274 (40%), Positives = 171/274 (62%), Gaps = 10/274 (3%) Query: 15 VRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETT 74 V + +K++ +I+ PGLAVVL+G++PAS++YV K K +G VS+++ LP Sbjct: 8 VAERILEKLKQKISQSPTPPGLAVVLIGNDPASEVYVGMKVKKAMNLGMVSKAHRLPSDA 67 Query: 75 SEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNV-GRLCQ 133 + ++L+LI+ LN D TI GILVQ+PLP +D+ +++ I P+KDVDG HP N+ L Sbjct: 68 TLTDILKLIERLNNDPTIHGILVQIPLPKHLDSNVIIQAISPEKDVDGLHPVNMGKLLLG 127 Query: 134 RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL----LAGCTTTVT 189 + PCTP ++ LL Y+I G + V+G SNIVG+P++ L+ T T+ Sbjct: 128 QLGGFSPCTPAAVIELLNYYDIPLQGRHVAVVGRSNIVGKPLAAMLMQKHPTTNATVTLL 187 Query: 190 HRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL--ENGK---VVGDV 244 H ++N ++ AD+++ AVG P FI + I A+++DVGI+R+ N K +VGDV Sbjct: 188 HSQSQNFTEILKTADIIVAAVGVPLFIQENMISPNAVIVDVGISRVATNNDKGYMLVGDV 247 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 F + + ITPVPGGVGPMTVA L++NT ++ Sbjct: 248 DFNNVVTKCKAITPVPGGVGPMTVAMLMKNTWES 281 >UniRef50_UPI00015B59A5 PREDICTED: similar to ENSANGP00000016878 n=2 Tax=Eumetazoa RepID=UPI00015B59A5 Length = 866 Score = 207 bits (526), Expect = 5e-52, Method: Compositional matrix adjust. Identities = 120/283 (42%), Positives = 171/283 (60%), Gaps = 12/283 (4%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGL--RAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 ++ G +A+++R +A+ V A I L APGLA+V VG S +Y+ K KA E+G Sbjct: 9 VLSGTDLAKEIRESLAKDVAA-IQQKLPNYAPGLAIVQVGGREDSNVYIRMKIKAASEIG 67 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPA--GIDNVKVLERIHPDKDV 120 + +P TT+E ELL ++ LN D GI+VQ+PL + I++ + + + PDKDV Sbjct: 68 IKATHVKMPNTTTEHELLTKLNKLNNDPDTHGIIVQMPLDSVNKINSHLITDTVSPDKDV 127 Query: 121 DGFHPYNVGRLC-QRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 DG + N GR+ PCTP G + L++R + G AVV+G S IVG P++ L Sbjct: 128 DGLNTINEGRVAIGDMSGFLPCTPNGCIELIKRSGVPIAGAQAVVLGRSKIVGTPVAELL 187 Query: 180 LLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN-- 237 T TV H TK+L V AD+++V +G+P + G WIK GA+VID GIN + + Sbjct: 188 KWHNATVTVCHSRTKDLPSVVSKADIVVVGIGQPELVKGSWIKPGAVVIDCGINSIPDPT 247 Query: 238 ----GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 ++VGDV + +AAK ASYITPVPGGVGPMTVA L++NT+ Sbjct: 248 KKSGQRLVGDVDYAEAAKVASYITPVPGGVGPMTVAMLMKNTV 290 >UniRef50_O65269 F6N23.28 protein n=1 Tax=Arabidopsis thaliana RepID=O65269_ARATH Length = 310 Score = 202 bits (514), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 105/223 (47%), Positives = 141/223 (63%), Gaps = 8/223 (3%) Query: 72 ETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRL 131 E +SE E+L+ + N D ++ G+LVQLPLP+ +D +L + +KDVDGFHP N+GRL Sbjct: 88 EDSSEEEVLKYVSGFNDDPSVHGVLVQLPLPSHMDEQNILNAVSIEKDVDGFHPLNIGRL 147 Query: 132 CQRA--PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVT 189 R P PCTP+G + LL RYNI+ G AVVIG SNIVG P ++ L T ++ Sbjct: 148 AMRGREPLFVPCTPKGCIELLHRYNIEFKGKRAVVIGRSNIVGMPAALLLQKEDATVSII 207 Query: 190 HRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN------GKVVGD 243 H T N AD+LI AVGKP + G WIK GA++IDVGI +E+ ++VGD Sbjct: 208 HSRTMNPEELTRQADILISAVGKPNMVRGSWIKPGAVLIDVGIKPVEDPSAAGGERLVGD 267 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 + + +A+K AS ITPVPG VGPMT+A L+ NTL + H+ Q Sbjct: 268 ICYVEASKIASAITPVPGDVGPMTIAMLLSNTLTSAKRIHNFQ 310 >UniRef50_A9UXQ1 Predicted protein n=7 Tax=cellular organisms RepID=A9UXQ1_MONBE Length = 882 Score = 201 bits (512), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 123/288 (42%), Positives = 166/288 (57%), Gaps = 37/288 (12%) Query: 3 AKIIDGKTIAQQV--RSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 AKIIDGK IAQ V R + A ++ ++ AG P + + Sbjct: 2 AKIIDGKAIAQYVGGRDDSAVYIRMKVRAGNELPAVTFAHM------------------- 42 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAG--IDNVKVLERIHPDK 118 + SR + L + +LLE I LN D + GI+VQLPL + ID V + + P+K Sbjct: 43 --YRSRLFCL----AHPQLLECIRALNDDMDVHGIIVQLPLDSQEEIDEVTITNAVRPEK 96 Query: 119 DVDGFHPYNVGRLCQRA--PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMS 176 DVDGF YN G L Q+ P L CTP+G + L+E I+ G +AVVIG S+IVGRP+S Sbjct: 97 DVDGFTRYNTGALAQKGELPLLYACTPKGCMHLIESTGIELSGKHAVVIGRSDIVGRPVS 156 Query: 177 MELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE 236 L T T+ H T NL+ V AD+++ AVG+PG + GDW+K GA+VID GIN +E Sbjct: 157 YLLTRRNATVTLCHSRTTNLKEEVARADIVVAAVGQPGLVQGDWLKPGAVVIDCGINSIE 216 Query: 237 NG------KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 + ++VGDV F A++ A +ITPVPGGVGPMTVA L+ NT+ A Sbjct: 217 DSSKKSGFRLVGDVDFASASQVAGHITPVPGGVGPMTVAMLMGNTVAA 264 >UniRef50_C1XHV3 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); methenyltetrahydrofolate cyclohydrolase n=2 Tax=Bacteria RepID=C1XHV3_MEIRU Length = 293 Score = 200 bits (509), Expect = 4e-50, Method: Compositional matrix adjust. Identities = 120/272 (44%), Positives = 162/272 (59%), Gaps = 6/272 (2%) Query: 15 VRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETT 74 V V Q++Q +A P L VV +G +PAS YV K + + +G S+ PE+T Sbjct: 9 VAEAVYQELQTLLATLPYVPHLRVVRLGDDPASVAYVRLKDRQAKRLGLSSQVDVFPEST 68 Query: 75 SEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQR 134 S+ ELL I LNAD +DGILVQ P+P +D VLE I P KDVDG P N GR+ Sbjct: 69 SQEELLAHIARLNADPEVDGILVQSPVPRQVDFNAVLEAIDPLKDVDGLTPVNAGRMWMG 128 Query: 135 APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTK 194 L CTP G++ LL+ Y I G V++G SN+VG+P++ +L T T+ H T+ Sbjct: 129 LEALESCTPAGVMRLLKHYQIPLAGKEVVIVGRSNLVGKPLAALMLREHATVTLAHSRTQ 188 Query: 195 NLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL---ENGK--VVGDVVFEDA 249 +L AD+L+ AVGK G I + ++ GA+V+DVGINR+ E G+ +VGDV Sbjct: 189 DLAAVCRRADVLVAAVGKAGLITPEMVRPGAVVVDVGINRVGQNEKGRDILVGDVA-PGV 247 Query: 250 AKRASYITPVPGGVGPMTVATLIENTLQACVE 281 A AS +TPVPGGVGPMTVA L+ NT+ A + Sbjct: 248 AAVASALTPVPGGVGPMTVAMLLYNTVIAAMR 279 >UniRef50_B5IEC2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein n=2 Tax=Aciduliprofundum boonei T469 RepID=B5IEC2_9EURY Length = 273 Score = 200 bits (508), Expect = 5e-50, Method: Compositional matrix adjust. Identities = 116/275 (42%), Positives = 169/275 (61%), Gaps = 10/275 (3%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 II+ KT+A+++R ++ + + L ++VG + AS +Y S K ++GF Sbjct: 2 IIECKTLAKEIRENAKKEAKGK------KLWLHNIVVGGDEASLVYARSNLKLLRKLGFD 55 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + + L E SE ELL+LI LN D+++ GI+V PLP ID +KV I P KDVDG + Sbjct: 56 GKIHHL-EEASERELLDLIQALNEDDSVHGIMVNFPLPDNIDPMKVRSTISPIKDVDGIN 114 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 P N G+L L P TPR ++ +LER + G + ++I + +VG+P+S+ LL Sbjct: 115 PINYGKLLLGEEILTPNTPRAVIRILERET-ELRGKDVLIINRTPVVGKPLSLLLLNRDA 173 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+ H T+NL+ AD+++VAVGKP F+ D + EGAI+IDVGIN + NGK+VGD Sbjct: 174 TPTIAHSKTRNLKEKALEADVIVVAVGKPKFLKEDMVHEGAIIIDVGINVV-NGKIVGDA 232 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 F+ K+A ITPVPGGVG +T A LIEN ++A Sbjct: 233 DFDSIEKKAK-ITPVPGGVGTVTNACLIENLVKAA 266 >UniRef50_A8SN78 Putative uncharacterized protein n=1 Tax=Parvimonas micra ATCC 33270 RepID=A8SN78_9FIRM Length = 283 Score = 200 bits (508), Expect = 5e-50, Method: Compositional matrix adjust. Identities = 106/275 (38%), Positives = 163/275 (59%), Gaps = 2/275 (0%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+ GK +A ++ ++ V A + + + VG S Y + K +G Sbjct: 4 IMKGKEVAIALKEKIKAGV-AELKEKGKVTTCGFIRVGDRSDSIGYENAAIKVLSSLGIE 62 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + PE +EA+ + ++ + D+++DG L+ PLPA ID+ V +I+P KD+DG Sbjct: 63 CVQFHYPEDITEADFISELEKIGNDDSVDGFLLLRPLPAHIDDDLVGMKINPKKDIDGVS 122 Query: 125 PYNVGRLCQ-RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 PYN+G + + PCT ++ +LE Y++D G NAVV+G SN++G+P++M LL Sbjct: 123 PYNIGEVFYPKEDSFIPCTAAAVIKMLEFYDLDLTGKNAVVLGRSNVIGKPVAMLLLAKN 182 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T TV H T+NL+ +NAD+L+ A+GK F+ + +KEGAIV+DVG N ENGKV GD Sbjct: 183 ATVTVCHSRTQNLKEVCKNADVLVSAIGKAHFVTKELVKEGAIVVDVGTNYDENGKVTGD 242 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 V F++ ++ ASYI PVPGG+G +T + L E L A Sbjct: 243 VDFDEVSEIASYINPVPGGIGSITTSVLAEKCLIA 277 >UniRef50_D2W298 Predicted protein n=2 Tax=Naegleria gruberi RepID=D2W298_NAEGR Length = 319 Score = 200 bits (508), Expect = 6e-50, Method: Compositional matrix adjust. Identities = 118/299 (39%), Positives = 186/299 (62%), Gaps = 26/299 (8%) Query: 5 IIDGKTIAQQVRSEVAQK----VQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 +I+G IA +++ E+ + V+ + +R PGLAVV+VGS S YV K++AC E Sbjct: 12 LINGLEIAAEIKEEIKRDIERIVEKQKGGQVRRPGLAVVMVGSRKDSLTYVQRKQEACAE 71 Query: 61 VGFVS--RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDK 118 +G S ++ ++ ++ ++++ I NAD+ + GILVQLPLP+ ++ K+LE I P K Sbjct: 72 LGIESFKTHFEDDQSVTDEDVIKTIQQYNADDRVHGILVQLPLPSHLNEEKILESISPAK 131 Query: 119 DVDGFHPYNVGRLCQRAPRL------RPCTPRGIVTLLER----YNIDTFGLNAVVIGAS 168 DVDG ++ G + + +L PCTP GI+ ++ R N++ GL++VV+GAS Sbjct: 132 DVDGLTQFSFGLISMKGRKLVDGINFVPCTPLGIMEMIRRTAQKLNMNLEGLDSVVVGAS 191 Query: 169 NIVGRPMSMELLLAGCTTTVT--HRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAI 226 NIVG P ++ +LL T+V H ++N+ + AD+L+V G I +WIK+GAI Sbjct: 192 NIVGIPTAL-VLLNQLQTSVQLLHIKSQNIPEKISKADILVVCCGCAEIIKPEWIKKGAI 250 Query: 227 VIDVGINRLENG------KVVGDVVFED-AAKRASYITPVPGGVGPMTVATLIENTLQA 278 VIDVG+ +E+ ++VGDV+F+D KRAS TPVPGGVGP+T+A+L++NT + Sbjct: 251 VIDVGLTPVEDKTQERGFRLVGDVLFDDNLKKRASAATPVPGGVGPVTIASLMKNTYHS 309 >UniRef50_UPI00006CCCC6 methylenetetrahydrofolate dehydrogenase n=1 Tax=Tetrahymena thermophila RepID=UPI00006CCCC6 Length = 342 Score = 200 bits (508), Expect = 6e-50, Method: Compositional matrix adjust. Identities = 112/280 (40%), Positives = 167/280 (59%), Gaps = 9/280 (3%) Query: 5 IIDGKTIAQQVRSEVAQKVQ--ARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 + +G A+++ S + ++++ + + R PGL ++LVG+NPAS Y+ K +ACE +G Sbjct: 18 VFNGNKSAKKILSSLRKEIEWFQKQSDLSRKPGLGIILVGNNPASLSYIKKKLQACEAIG 77 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 Y E E ++L ID LN + ID I+ QLPLP+ ID V+ I +KD DG Sbjct: 78 IRHELYHFSEDIQEYDVLSAIDNLNRKDDIDAIMAQLPLPSHIDKNNVINMISSEKDADG 137 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL-LL 181 N L +A + PCTP + +LE + I + V+IG +VG+P+ L L Sbjct: 138 LK-LNSNNLDPKA-NILPCTPAACLKILEEHQICLKDKHVVLIGRGRLVGQPLEQLLSKL 195 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINR----LEN 237 + T + T +++ H+ AD++I A G+ I G WIK+GAIV+DVG+N+ ++ Sbjct: 196 SPAQITTCVKETGDIKQHILKADVIIAAAGERQLIKGKWIKKGAIVLDVGVNKGIPGIDP 255 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 KVVGDV FE+A KRAS ITPVPGG+GPMTV+ L+ NT+Q Sbjct: 256 TKVVGDVEFEEAKKRASLITPVPGGIGPMTVSMLMYNTVQ 295 >UniRef50_A0DMT9 Chromosome undetermined scaffold_57, whole genome shotgun sequence n=2 Tax=Paramecium tetraurelia RepID=A0DMT9_PARTE Length = 309 Score = 199 bits (507), Expect = 8e-50, Method: Compositional matrix adjust. Identities = 107/249 (42%), Positives = 146/249 (58%), Gaps = 4/249 (1%) Query: 29 AGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNA 88 + L PGLA++ VG+NP+S YV K CEE Y PET S+ E++ I +LN Sbjct: 32 SALMRPGLAIIQVGNNPSSLTYVRKKIALCEEHQIHHELYHFPETISQKEIVHRIKSLNQ 91 Query: 89 DNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAP--RLRPCTPRGI 146 +IDGILVQLPLP + +++ I +KD+D H N L Q + PCTP + Sbjct: 92 KGSIDGILVQLPLPPHLSRLEISNEIKLNKDIDCLHMANFQNLLQNGEDNDIIPCTPAAV 151 Query: 147 VTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLL 206 + +L+ NID N VIG S +VG P+S+ LL T+ H T ++ HVE AD++ Sbjct: 152 LHILDTQNIDVRNQNVTVIGRSQLVGFPLSVLLLKRNARVTICHSET-TVQEHVEKADIV 210 Query: 207 IVAVGKPGFIPGDWIKEGAIVIDVGINRLE-NGKVVGDVVFEDAAKRASYITPVPGGVGP 265 I G + G+WIK GA VIDVGI R+ ++VGD+ F+ A R S+ITPVPGGVGP Sbjct: 211 ISCAGHKELVKGEWIKNGAKVIDVGITRIPGTNQIVGDIEFQKALPRVSFITPVPGGVGP 270 Query: 266 MTVATLIEN 274 +TV+ L N Sbjct: 271 LTVSMLFRN 279 >UniRef50_C5C958 Methenyltetrahydrofolate cyclohydrolase n=118 Tax=Actinobacteria (class) RepID=FOLD_MICLC Length = 303 Score = 199 bits (506), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 121/301 (40%), Positives = 172/301 (57%), Gaps = 20/301 (6%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M AK++DGK A ++ E+ +V A G R PGL +LVG + SQ YVA K + C E Sbjct: 1 MTAKVLDGKATAAAIKEELRGRVAALAERG-RTPGLGTLLVGEDAGSQKYVAGKHRDCAE 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG S +LP +E ++L+++ LN D G +VQLPLP +D KVLE I PDKD Sbjct: 60 VGIESIQRELPADATEEQILDVVRELNEDPACTGYIVQLPLPKHVDTQKVLEAIDPDKDA 119 Query: 121 DGFHPYNVGRLCQR------APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRP 174 DG HP N+GRL +P PCTP G V LL + ++ G + +VIG +GRP Sbjct: 120 DGLHPMNLGRLVASVGGELDSP--LPCTPAGCVELLRHHGVELAGKHVLVIGRGVTIGRP 177 Query: 175 MSMELLL--AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGI 232 + L T T+ H T NL + +AD++I A G + + +KEG IV+DVG+ Sbjct: 178 AGLVLTRREVNATVTLAHTGTTNLDELLASADVVIAAAGSAHMVTPEQVKEGVIVLDVGV 237 Query: 233 NRL--ENGK--VVGDVVFEDAA--KRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 +R+ E+GK V+GDV D A ++A+++ P PGGVGPMT L+ N ++A D + Sbjct: 238 SRVTGEDGKSRVLGDV---DPAVKEKAAWMAPNPGGVGPMTRVMLLANVVEAAERAADGE 294 Query: 287 D 287 + Sbjct: 295 N 295 >UniRef50_Q83FS2 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Tropheryma whipplei RepID=FOLD_TROWT Length = 295 Score = 198 bits (504), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 119/284 (41%), Positives = 161/284 (56%), Gaps = 9/284 (3%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M AK++DG ++ + E + + P LA VLVG+NPAS+ YV SK + C+ Sbjct: 1 MVAKVLDGLAVSAGIF-ERLHRACCELENNGVCPKLATVLVGNNPASRSYVLSKHRDCKN 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G S +LP TSE EL+ ++ LNA + + GI+VQLPLP ID KV+E I+PDKD Sbjct: 60 IGIQSTLIELPANTSEKELISKVEILNASSDVSGIIVQLPLPESIDQNKVIEAINPDKDA 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG HP N+G L + PCTP GIV LLE + I G VIG VGRP+ + L Sbjct: 120 DGLHPLNLGYLVTGKQGIVPCTPAGIVKLLEAHRITLEGKTIAVIGRGTTVGRPLGILLS 179 Query: 181 LAGCTTTV--THRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINR---L 235 G TV H ++N+ AD+++ G + WIK GA+V+DVGIN+ Sbjct: 180 GKGVNATVINIHSRSRNISGLSRIADVVVACAGVKHIVEPSWIKPGAVVVDVGINQSGVS 239 Query: 236 ENGKVV--GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 +GK++ GD V ASYI+PV GGVGPMT A L+ N + Sbjct: 240 SSGKMILTGD-VHPLTKNIASYISPVVGGVGPMTRAMLMSNVIN 282 >UniRef50_C1FDF4 5,10-methylene-tetrahydrofolate dehydrogenase/cyclohydrolase n=1 Tax=Micromonas sp. RCC299 RepID=C1FDF4_9CHLO Length = 396 Score = 196 bits (497), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 122/331 (36%), Positives = 173/331 (52%), Gaps = 57/331 (17%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQ-ARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 +A ++DG+ A + + E+A K+ R + + PGLA V++G P S +YV K +ACEE Sbjct: 56 SAIMLDGRLQAARWKREIAAKILFRRTSKRMGPPGLAAVVIGDRPDSLLYVRRKSEACEE 115 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG LP + ++ ++ LN+D+ GI++QLP+P ++ ++L I+P KDV Sbjct: 116 VGIRFHLERLPGDADQDMVVNVLRKLNSDDRFHGIMLQLPVPVHLNESRLLGSINPMKDV 175 Query: 121 DGFHPYNVGRLCQRA---PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSM 177 DG HPYNVGRL R P PC P G V LL R NI G + V+G SN+VG P+S Sbjct: 176 DGLHPYNVGRLAMRGTWRPAFIPCAPLGCVELLWRENIQIKGRSVAVLGDSNVVGMPISW 235 Query: 178 ELLLAGCTT-TVTHRFT-------------------KNLRHHVENADLLIVAVGKPGFIP 217 L +G +T V H + NL + V NAD++I A+G+ I Sbjct: 236 LLRDSGASTINVVHGYWLKVPEQNNMKFPAQANFVEPNLLNTVRNADIIISAIGRAEVIK 295 Query: 218 GDWIKEGAIVIDVGINRL---------------------------------ENGKVVGDV 244 DW+K GA VIDVGIN + + KVVGDV Sbjct: 296 RDWVKAGATVIDVGINPIPWDHHEGIARCRHASSRKVPAAFLEQRPDKPEKSDYKVVGDV 355 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENT 275 E+ + A+ +TPVPGG+GPMT+A L+ NT Sbjct: 356 AAEEVSHVANAMTPVPGGIGPMTIAALLSNT 386 >UniRef50_Q0AWX5 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Syntrophomonas wolfei subsp. wolfei str. Goettingen RepID=FOLD2_SYNWW Length = 272 Score = 195 bits (495), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 105/270 (38%), Positives = 157/270 (58%), Gaps = 7/270 (2%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 +I GK I +Q++ V Q + GLA++ VG +P+S YV RK EE G Sbjct: 2 LIYGKDIREQIKERVRQSAEEV------KMGLAIIRVGDDPSSMAYVRGIRKFAEETGVK 55 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 +LP+ E ELL+ I LN + I GI++Q PLPA ++ ++ I DKDV+G H Sbjct: 56 VEIVNLPDAVGERELLKTIGDLNNSSEITGIMLQTPLPASLNASHLVNAIDFDKDVEGIH 115 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 YN+G+L + +RPCTP+ ++++L+ ++I G +IG S VG P+++ + Sbjct: 116 NYNLGKLISKEEGVRPCTPKAVISMLKAHDILIEGQKVTIIGRSMTVGSPLALMMTAENA 175 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T TV H T+NL+ AD+L+ AVGK F+ D + + +VIDVGIN ENGK++GD Sbjct: 176 TVTVCHTRTRNLKEEALRADILVAAVGKREFVTADMVHKDMVVIDVGINFDENGKMLGD- 234 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIEN 274 V E+A + VPGG+G +TVA L +N Sbjct: 235 VHEEARNHCRLASAVPGGIGVITVAELFDN 264 >UniRef50_A5CF58 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Orientia tsutsugamushi RepID=FOLD_ORITB Length = 301 Score = 194 bits (492), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 119/280 (42%), Positives = 155/280 (55%), Gaps = 6/280 (2%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+DGK +A+ E + A L ++LVG+N AS IYV +K + +G Sbjct: 4 IMDGKKLAELRLIETKNDLLALKDKYQITVKLVIILVGNNDASLIYVNNKVAKAKAIGMD 63 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S L E E +L +ID LN D+T+ GI+VQLPLP ID +K+ RI KDVDG + Sbjct: 64 SEIIRLFEFIEEKKLFSVIDDLNCDSTVHGIIVQLPLPPHIDALKLFARIDSRKDVDGLN 123 Query: 125 PYNVGRLCQRAPR-LRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 P N+G L A + L PCT G + LL+ Y G + VVIG SNIVG+P+S LL Sbjct: 124 PINIGYLNIGANQGLIPCTALGCIDLLQYYVTGLKGKHVVVIGKSNIVGKPLSALLLRNS 183 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL-----ENG 238 CT T+ H T +L H AD++I AVGK F+ IDVGI+ + Sbjct: 184 CTVTICHSATVDLALHTRTADIVISAVGKANFLTDKHFSGNLAFIDVGISHIYDLQTHKR 243 Query: 239 KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 K+VGD F +ITPVPGGVGPMTVA L++NTL A Sbjct: 244 KLVGDGDFLKIKDLVKFITPVPGGVGPMTVAYLLKNTLTA 283 >UniRef50_UPI00017F08E4 PREDICTED: similar to MGC137793 protein n=1 Tax=Sus scrofa RepID=UPI00017F08E4 Length = 933 Score = 191 bits (484), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 104/252 (41%), Positives = 151/252 (59%), Gaps = 10/252 (3%) Query: 41 VGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLP 100 VG+ S +Y+ K KA +E+G + LP T +E+E+L+ I +LN D T+ G ++QLP Sbjct: 59 VGNRDDSNLYINVKLKAAKEIGIKAMHIKLPRTATESEVLKCITSLNEDLTVHGFILQLP 118 Query: 101 LPAG--IDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPR--LRPCTPRGIVTLLERYNID 156 L + I+ ++ I P+KDVDG N G+L + PCTP+G + L+++ + Sbjct: 119 LDSENPINAEALINAIAPEKDVDGLTSINAGKLARGDLNDCFIPCTPKGCLELIKQTGVQ 178 Query: 157 TFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFI 216 G AVVIG S IVG PM LL T T H T NL V D+++VA GKP + Sbjct: 179 IAGRQAVVIGRSKIVGAPMHDLLLWNHATVTTCHSKTANLNEEVNKGDIVVVAAGKPEMV 238 Query: 217 PGDWIKEGAIVIDVGIN------RLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVAT 270 G+WIK GA+VID GIN + ++VGDV + +A +RA +ITPVPGGVGPMTVA Sbjct: 239 KGEWIKPGAVVIDCGINCKPDDTKPSGKRIVGDVAYSEAKERAGFITPVPGGVGPMTVAM 298 Query: 271 LIENTLQACVEY 282 L+++T+++ + Sbjct: 299 LMQSTVESAEHF 310 >UniRef50_B7QFP4 C1-tetrahydrofolate synthase, putative n=1 Tax=Ixodes scapularis RepID=B7QFP4_IXOSC Length = 297 Score = 190 bits (483), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 108/259 (41%), Positives = 147/259 (56%), Gaps = 11/259 (4%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 ++IDGK IA ++ +E+ + + + G R P L VLVG + S +YV +K KA E G Sbjct: 32 EVIDGKRIANEIETEIRSAINSDLVHGGRRPHLCAVLVGDDEGSAVYVKNKIKASERTGI 91 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S + LP +T++ +LL LI LN +DGILVQLPLP I+ + + P KDVDGF Sbjct: 92 TSENIHLPSSTTQTDLLSLIKKLNESKFVDGILVQLPLPRHIEESVICNSVLPSKDVDGF 151 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA- 182 H +GRLC L PCTP IV +L+R ++T G + VV G S IVG P+S+ L A Sbjct: 152 HALQMGRLCLNMDSLAPCTPLAIVEILQRTGVNTTGKHIVVCGRSTIVGLPISIMLGSAR 211 Query: 183 ---GCTTTVTHRFT--KNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 T + H T +LR V AD+++ A G PG I + +K G VIDVGI R+ + Sbjct: 212 SYGNATVSCCHSHTSPSDLRALVGMADIVVTATGVPGLIMANMVKHGVCVIDVGITRVHD 271 Query: 238 G-----KVVGDVVFEDAAK 251 K+VGDV FE K Sbjct: 272 SVTGKTKLVGDVDFEGKNK 290 >UniRef50_Q0S375 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=Actinobacteridae RepID=FOLD2_RHOSR Length = 286 Score = 190 bits (482), Expect = 5e-47, Method: Compositional matrix adjust. Identities = 121/281 (43%), Positives = 163/281 (58%), Gaps = 9/281 (3%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A I+DGK ++ ++ +V A G+ PGL VLVG +P S YV K C + Sbjct: 1 MTATILDGKATRDEIFEDLKVRVSALKDRGI-TPGLGTVLVGDDPGSAAYVRGKHNDCAK 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG S DLP ++ +L ID LNA+ G +VQLPLP +D LERI PDKD Sbjct: 60 VGITSIRRDLPGDITQEKLDATIDELNANPDCTGYIVQLPLPKQLDENAALERIDPDKDA 119 Query: 121 DGFHPYNVGRLC--QRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSME 178 DG HP N+GRL ++AP PCTPRGI+ LL RY + G + VV+G VGRP+ + Sbjct: 120 DGLHPVNLGRLVLGKKAP--LPCTPRGILHLLRRYEVPIEGAHVVVVGRGVTVGRPIGLL 177 Query: 179 LLLAGCTTTVT--HRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE 236 TVT H T++L V AD++I A G PG I D +K GA V+DVG++R Sbjct: 178 FTRRSENATVTLCHTRTRDLGAEVRRADIVIAAAGVPGLITADMVKPGAAVLDVGVSRTA 237 Query: 237 NGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 +G + GDV D A+ A +++P PGGVGP+T A L+ N ++ Sbjct: 238 DG-LRGDVA-ADVAEVAGFLSPNPGGVGPLTRAFLLTNVVE 276 >UniRef50_A9NE96 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Acholeplasma laidlawii PG-8A RepID=FOLD_ACHLI Length = 277 Score = 189 bits (481), Expect = 8e-47, Method: Compositional matrix adjust. Identities = 115/270 (42%), Positives = 157/270 (58%), Gaps = 5/270 (1%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 ++DG+ A + + KVQ + P L ++L+G++ AS+ YV K +G Sbjct: 2 LLDGRKTADILNEALRVKVQYLT----KKPKLEIILIGNDEASKSYVKGKLNTASNLGME 57 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 L E + + LI LN D + GIL+QLP+P +D+ ++ I KDVDGFH Sbjct: 58 VHINYLDEAIDQLSVEALIQKLNTDKGVHGILLQLPIPKHLDSDYLISLIDYKKDVDGFH 117 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 N G L Q+ +RP TP GI+ LL+ YNI G + V+IG S IVG P+S L Sbjct: 118 TMNQGLLFQKKDGIRPATPLGIMMLLDFYNIPIEGKHVVIIGRSQIVGAPLSKMFLDRNA 177 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+TH TKNL + AD+L+ A+GKP F+ D +K GA+V+DVGINR++ K+VGDV Sbjct: 178 TVTITHSKTKNLPSITKQADILVAAIGKPKFVTKDMVKVGAVVVDVGINRVDK-KLVGDV 236 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIEN 274 FE ASYITPVP GVGPMT+ L N Sbjct: 237 DFEHVEPIASYITPVPKGVGPMTICALAHN 266 >UniRef50_C0GE27 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GE27_9FIRM Length = 278 Score = 189 bits (480), Expect = 9e-47, Method: Compositional matrix adjust. Identities = 113/279 (40%), Positives = 157/279 (56%), Gaps = 2/279 (0%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M+A+IIDG +A +++ ++ Q V + + PGLA+V+V S A + K++ CE+ Sbjct: 1 MSARIIDGSAVAGELQQQIKQDVAKLKSENKQLPGLAIVVVSSPKARKNIAELKKRMCEK 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG + L + + +++ LI+ LN D I GI + P+P ID V++ + P KDV Sbjct: 61 VGIHCEIHKLNPLSGQDDVIALIEKLNKDPKITGINIH-PVPDHIDYRAVVQALDPAKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 +G HP N G + P TPR I+ LLE D G AV++G S VG P+ LL Sbjct: 120 EGVHPMNQGNFLIGDKKFIPFTPRAIMRLLESTGEDLKGKRAVIVGRSQHVGLPVGFLLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T T H + L AD+LIVA G P I G IK GAIVIDVG N + G++ Sbjct: 180 EKHATVTYAHSRSWYLEDVTRLADILIVAAGHPEMITGSMIKPGAIVIDVGTN-IVGGQL 238 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 VGDV A + A +ITPVPGGVGPMTVA L+ N ++ C Sbjct: 239 VGDVEHHTAQRVAGWITPVPGGVGPMTVAMLLMNLVECC 277 >UniRef50_C8WXG8 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WXG8_ALIAD Length = 286 Score = 188 bits (478), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 105/277 (37%), Positives = 158/277 (57%), Gaps = 3/277 (1%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A+ +DG+ A++V+ E+ ++V+ + G+ P L +++ ++ S +V K + G Sbjct: 4 AQRLDGRRAAERVQEELKRRVEELASRGI-LPKLVMLVSEADEVSLGHVRRKARFARGAG 62 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 V+ L ID LN D+ +D ILVQLPLPAG D ++L R+ PDKDVDG Sbjct: 63 LVAEIRTFRAAEGPDALRSAIDRLNEDDEVDAILVQLPLPAGWDEGEILRRVRPDKDVDG 122 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 HP N+G++ PR+ PCT RG+ LL ++ I G A VIG S +VG P++ + Sbjct: 123 LHPENLGQMAYGLPRVWPCTARGVGELLHQHEIGVHGKVACVIGRSPLVGWPIAQWFMAH 182 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 G T HR T ++ AD+++ A G PG + + ++ GA+VIDVG+ +G G Sbjct: 183 GATVVQCHRQTPSVAVWTRQADIVVSAAGAPGLVGAEEVRPGAVVIDVGLTYTADGP-RG 241 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 D V +RAS++TPVPGGVGPMTVA + +N C Sbjct: 242 D-VDPGVRERASWLTPVPGGVGPMTVAMVAQNAFDLC 277 >UniRef50_Q21285 Dauer or aging adult overexpression protein 3, confirmed by transcript evidence n=2 Tax=Caenorhabditis RepID=Q21285_CAEEL Length = 303 Score = 188 bits (477), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 121/290 (41%), Positives = 164/290 (56%), Gaps = 15/290 (5%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKV-QARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACE 59 M A+I+ G +++V +V QK+ + R LA+V VG+ S +Y+ SK K + Sbjct: 1 MVAEIVSGLEYSKKVLHDVGQKIAKTREHHPNFHAVLAIVQVGNRSDSNVYINSKLKKAK 60 Query: 60 EVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAG--IDNVKVLERIHPD 117 E+G + LP+T ++ +L I LN DN IDGI++QLPL ID V++ I P Sbjct: 61 EIGADGKLIKLPDTITQGDLKREIMALNHDNEIDGIIIQLPLDCKHEIDADSVIDLIDPL 120 Query: 118 KDVDGFHPYNVGRLC----QRAPRLRPCTPRGIVTLLERYNIDT---FGLNAVVIGASNI 170 KDVDG N GRL QR + PCTP G + L+++ D G VV+G S I Sbjct: 121 KDVDGLTRINAGRLARGELQRT--IFPCTPFGCLYLVQQATGDANFVSGKEVVVLGRSKI 178 Query: 171 VGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDV 230 VG P + L T T+ H T NL+ AD+LIVA+G+ F+ DWIK GA VID Sbjct: 179 VGSPAAALFLWHHGTVTICHSKTPNLKEKCLRADILIVAIGRKHFVKADWIKPGAFVIDC 238 Query: 231 GINRLEN---GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 GIN ++ K+ GDV E A + A ++TPVPGGVGPMTVA LI NT + Sbjct: 239 GINVGDDPNSRKIYGDVDTEAAKEVAGFLTPVPGGVGPMTVAMLIRNTFE 288 >UniRef50_Q04FB7 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=Leuconostocaceae RepID=FOLD_OENOB Length = 285 Score = 187 bits (474), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 111/281 (39%), Positives = 158/281 (56%), Gaps = 9/281 (3%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +I+DG+++++++ EV KV AG LA + N S++YV K + G Sbjct: 3 QILDGRSVSKKILQEVKDKVAK---AGFPVK-LATIYNEENEGSKMYVGMKIRRATFAGL 58 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 +S Y + + ++L L+ LN D++I GILVQ PL GID K+ I P KD DG Sbjct: 59 ISVEYKVDNSWKTDDILRLLSKLNMDSSICGILVQSPLGDGIDESKIFNAIDPLKDADGL 118 Query: 124 HPYNVGRLCQRAPR--LRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 +N G L + A + P TP G+++LLE Y+ NA+V+G S + GRPMS+ L Sbjct: 119 SAFNQGLLFENAKENYIVPATPAGVISLLEAYHYQFAAKNALVVGRSVLFGRPMSVLLTN 178 Query: 182 AGCTTTVTHRFT--KNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGK 239 T T+ H T LR + ADL++VA+GK + +K+ +VIDVG N+L NG Sbjct: 179 RDMTVTLAHSKTPVDQLRQFAKRADLIVVAIGKANWFQFTDLKKDVVVIDVGANKL-NGH 237 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 GDV FE S I+PVPGGVGPMT+ATLI++T V Sbjct: 238 ATGDVDFEKVYPHVSQISPVPGGVGPMTIATLIKHTFDLAV 278 >UniRef50_Q4T2B9 Chromosome undetermined SCAF10300, whole genome shotgun sequence n=10 Tax=cellular organisms RepID=Q4T2B9_TETNG Length = 348 Score = 186 bits (472), Expect = 8e-46, Method: Compositional matrix adjust. Identities = 104/252 (41%), Positives = 147/252 (58%), Gaps = 10/252 (3%) Query: 41 VGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLP 100 VG S +Y+++K KA E+G ++ LP + ++ E+L I ++N D ++ G++VQLP Sbjct: 89 VGDRDDSNLYISAKMKAAAEIGIDAKHVRLPSSATQEEVLLNILSINEDQSVHGLIVQLP 148 Query: 101 LPA--GIDNVKVLERIHPDKDVDGFHPYNVGRLCQ--RAPRLRPCTPRGIVTLLERYNID 156 L + ID+ + + DKDVDG N GRL + PCTP G + L+ + + Sbjct: 149 LDSVHHIDSECITNTVSADKDVDGLSCINAGRLSRGDLDACFLPCTPSGCLELIRQTGVS 208 Query: 157 TFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFI 216 G AVVIG S IVG PM LL T T H T +L V AD+L+V G+ + Sbjct: 209 LEGKQAVVIGRSKIVGAPMHDLLLWNHATVTTCHSKTPDLPEQVGRADILVVGAGRAEMV 268 Query: 217 PGDWIKEGAIVIDVGIN------RLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVAT 270 G+W+KEGA+VID GIN R +VVGDV + A +RA +ITPVPGGVGPMTVA Sbjct: 269 RGEWLKEGAVVIDCGINQVPDCTRASGKRVVGDVHYASAHQRAGFITPVPGGVGPMTVAM 328 Query: 271 LIENTLQACVEY 282 L++NT+++ Y Sbjct: 329 LMQNTVRSAQRY 340 >UniRef50_A5N5B5 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=Clostridiales RepID=FOLD_CLOK5 Length = 284 Score = 184 bits (467), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 104/276 (37%), Positives = 154/276 (55%), Gaps = 2/276 (0%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 II GK +A + + ++V G+ P L ++ VG+ + Y K C +G Sbjct: 4 IIKGKPVADAISETLIKEVDNFKIQGI-IPKLVIIRVGAKASDLAYEKGILKRCNGIGIE 62 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + + PE S+ E + + LN D +DGI+V PLP +D + I P+KD+D F+ Sbjct: 63 TYVKEFPEDISQREFIRELRRLNEDRNVDGIMVFRPLPKHLDENIIKYVITPEKDIDCFN 122 Query: 125 PYNVGR-LCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 P N+ + + + PCTPR ++ +L+ YNID G +VVIG S IVG+PMSM LL Sbjct: 123 PINLAKVIAGDSTGFAPCTPRAVMEILKYYNIDVEGKFSVVIGRSMIVGKPMSMLLLNEN 182 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T T H T +L AD+L+ +GK FI +IKEGA+VIDVGIN + GK+ GD Sbjct: 183 STVTTCHSKTVHLDKICSQADILVAGIGKAEFIDSKYIKEGAVVIDVGINVDKYGKLCGD 242 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 V + + +TPVPGGVG +T + L ++ ++AC Sbjct: 243 VDIKSCQWKNVIVTPVPGGVGTVTSSVLAQHVVEAC 278 >UniRef50_B0VGJ7 FolD bifunctional protein n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VGJ7_9BACT Length = 307 Score = 182 bits (463), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 105/286 (36%), Positives = 166/286 (58%), Gaps = 12/286 (4%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 K+++GK +AQ + + + GL+ P + ++ VG +PAS YV S + +++G Sbjct: 7 KVLNGKPVAQLINRTCSSLIANY---GLK-PQMVLIQVGDDPASTYYVQSIINSGKKLGC 62 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + L + SE ELL +++ N + ++GI++Q PLP I+ KV I+P KD+D Sbjct: 63 FCQMKILLDNISEQELLAILNEANHNPDVNGIMLQKPLPKHINESKVNSAINPAKDLDCL 122 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL--- 180 HP N+G++ PCTP ++ + Y I+T G + V++G SN+VG+P++ LL Sbjct: 123 HPLNLGKIMLEEEGFLPCTPAAVLFCMLYYGIETQGKHIVILGRSNVVGKPLANILLWKR 182 Query: 181 -LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGIN--RLEN 237 A T TV H T NL + AD+LI A+GK F+ + +KE AI++DVGIN +L N Sbjct: 183 SFANATVTVCHSKTNNLAEFTKEADILITAIGKAEFVTPEMVKENAIILDVGINEIKLAN 242 Query: 238 GK--VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 G+ VGDV + +A ITPVPGG+G +T + L N + AC++ Sbjct: 243 GESNYVGDVNYSLCYDKALAITPVPGGIGRITTSVLFLNLVDACLK 288 >UniRef50_C1BVL5 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial n=2 Tax=Caligidae RepID=C1BVL5_9MAXI Length = 309 Score = 181 bits (458), Expect = 4e-44, Method: Compositional matrix adjust. Identities = 117/292 (40%), Positives = 175/292 (59%), Gaps = 23/292 (7%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 IDGK IA + + + +V++ ++ +P L +LVGS+PAS+IY+ K++A ++G Sbjct: 9 IDGKAIANGILAGLKSEVESFVSKYGCSPKLVPILVGSDPASEIYLKRKQEAASKIGIDC 68 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 L E T+E ++ I LN D + GI+VQLPLP+ + +V E I+ KDVD F Sbjct: 69 SIIRLHEKTTEESVISEICKLNQDPLVHGIIVQLPLPSEVREKEVCETINGLKDVDAFGL 128 Query: 126 YNVGRLCQRAPR--LRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 ++G++ R L PCTP + +++ ID G NAV++G S+ VG P++ LLLA Sbjct: 129 AHLGQIILNPLRSDLIPCTPLAVYKIIKSLEIDLSGKNAVILGRSHNVGMPIA--LLLAA 186 Query: 184 --------CTTTVTHRFT--KNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGIN 233 TTT+ HR T + L V+ AD+++ AVGKPG D IK+GA+++DVGI Sbjct: 187 DHIKGGFNMTTTICHRATPPEELEVAVKRADVIVSAVGKPGLARRDMIKKGAVIVDVGIT 246 Query: 234 RLENG----KVVGDV---VFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 R+++ K+ GDV V D AS++TPVPGGVGP TVA L+ NT++A Sbjct: 247 RVKDKDDRYKLFGDVDPLVLMDGI--ASHMTPVPGGVGPCTVACLMHNTVRA 296 >UniRef50_C4FZX7 Putative uncharacterized protein n=1 Tax=Abiotrophia defectiva ATCC 49176 RepID=C4FZX7_ABIDE Length = 283 Score = 181 bits (458), Expect = 4e-44, Method: Compositional matrix adjust. Identities = 94/276 (34%), Positives = 149/276 (53%), Gaps = 1/276 (0%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 KII GK +A+ + +E+ K ++ R P L ++ VG P Y K + +G Sbjct: 2 KIISGKEVAEHITAELKNKAESLKKGNRRLPKLVIIRVGEKPDDLSYQKGAVKRMDMIGV 61 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + E + E + D +N D ++DGILV P+P +D +++ I+P KD+D Sbjct: 62 IHEEVHFEENVPKEEFYKEFDEINNDESVDGILVLRPIPKHLDEDRLMNTINPKKDIDAI 121 Query: 124 HPYNVGRLCQRAPR-LRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 P ++G+L PCT G++ +L+ + G +IG SN+VGRP+++ + Sbjct: 122 SPVSLGKLMTGDKNGFAPCTAAGVIEILKYAGVKIRGKKVTIIGRSNVVGRPLALLFVSE 181 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T TV H FT +++ +NA++L+ + GK I +++ E A+VIDVGIN ENGK+ G Sbjct: 182 DATVTVCHSFTADVKQAGKNAEILVASCGKAKLINSEYVAENAVVIDVGINFDENGKLCG 241 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 DV D A+ TPVPGGVG +T + L + L A Sbjct: 242 DVDINDIEAVAAACTPVPGGVGAVTTSMLAKQLLLA 277 >UniRef50_D2RNA3 Methylenetetrahydrofolate dehydrogenase (NADP(+)) n=2 Tax=Acidaminococcus RepID=D2RNA3_ACIFE Length = 272 Score = 179 bits (454), Expect = 9e-44, Method: Compositional matrix adjust. Identities = 104/274 (37%), Positives = 154/274 (56%), Gaps = 7/274 (2%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M I+ GK +A+++R + +K + LA LVG NPA+ +Y S K Sbjct: 1 MEPIIMAGKPVAEEIRRNLREKFAGKELT------LATFLVGDNPAAHVYKRSLLKTAAS 54 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G +R +LPE S+ E + L+ D +DGIL +P P I ++++ ++ P+KD+ Sbjct: 55 LGIHTRDVELPEGASQEEAERALRALSEDPRVDGILPLVPFPWHISRMQLIRQLDPEKDM 114 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 D HP N G+L PCTPR + LL+ Y I G + V++G +VGRP+++ L+ Sbjct: 115 DCIHPINGGKLYLGITPWGPCTPRSCMALLDYYKIPLEGQHVVMVGYGEVVGRPLTLMLM 174 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T TV TKNL AD++I AVGKP I D I+EGA+V+DVGIN + +GK+ Sbjct: 175 GRYATVTVCRSRTKNLPAITRQADIIISAVGKPDLITEDMIREGAVVVDVGINSV-DGKL 233 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIEN 274 VGDV +AS TPVPGGVG ++ ++E Sbjct: 234 VGDVSEAAKKVKASAYTPVPGGVGVVSNLMVMET 267 >UniRef50_Q54VK0 Methenyl tetrahydrofolate cyclohydrolase / NADP-dependent methylene H4F dehydrogenase n=1 Tax=Dictyostelium discoideum RepID=Q54VK0_DICDI Length = 440 Score = 179 bits (454), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 104/294 (35%), Positives = 162/294 (55%), Gaps = 20/294 (6%) Query: 6 IDGKTIAQQV---RSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 +DGK +A + + + + I P L V+ VG + + Y+ +KR CE+VG Sbjct: 86 LDGKLLASHIVSSKKSIKADTEDFIKNSGVTPNLVVIYVGDSKQIESYIKAKRTGCEDVG 145 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 F E +L++ I + D ++ GI+VQLPLP ++ +++ I P KDVDG Sbjct: 146 FKFTLDRFSSDIKEDQLIKKIKYHSEDPSVHGIIVQLPLPDNLNKDAIIQSIDPKKDVDG 205 Query: 123 FHPYNVGR-LCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL-- 179 N+G+ + + P PCTP GI+ +L+ Y I G N VV+G SN+VGR ++ L Sbjct: 206 LTSTNLGQIMISKKPLYIPCTPLGILEILKAYKIKVEGKNVVVLGRSNLVGRTIATILSQ 265 Query: 180 -------LLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGI 232 ++ G T+ H+++KN + ADL+I A G PG I + +K G I+IDVGI Sbjct: 266 KDLTNPSIMNGANVTIIHKYSKNHLGSIRQADLIISATGVPGLIKKEDLKRGVILIDVGI 325 Query: 233 NRLENG------KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 + E+ K+VGD+ E ++ +Y TPVPGGVGP+TVA L+ N L++ + Sbjct: 326 SFKEDSTKKSGYKMVGDIDPEAYSRSIAY-TPVPGGVGPLTVACLLRNVLRSAI 378 >UniRef50_A0C3Q0 Chromosome undetermined scaffold_147, whole genome shotgun sequence n=2 Tax=Paramecium tetraurelia RepID=A0C3Q0_PARTE Length = 404 Score = 179 bits (454), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 107/256 (41%), Positives = 157/256 (61%), Gaps = 18/256 (7%) Query: 26 RIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDT 85 RI + ++ P L + LVG +PAS+ YV K KAC+E+ + ++ E + +L++ I Sbjct: 134 RITSEIK-PKLGICLVGDSPASKSYVNRKLKACQEINVDAEVFNFSENVGQEQLIKHIQQ 192 Query: 86 LNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNV------GRLCQRAPRLR 139 +N D GILVQLPLP+ ++ + ++ I +KDVD H +N+ G LC+ + Sbjct: 193 MNHD----GILVQLPLPSHLNKLDIIHSIPYEKDVDCLHMHNLQRILVYGELCE----ML 244 Query: 140 PCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHH 199 PCTP ++ +L+ Y+++ G +IG S +VG P+S+ L T TV HR T NL H Sbjct: 245 PCTPAAVLQILDYYDVNVIGKKVTMIGRSFLVGLPLSLLLQKRNATVTVCHRETLNLDQH 304 Query: 200 VENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE-NGKVVGDVVFEDAAKRASYITP 258 + NAD++I A G P + +K+GAIVIDVGI++ E GK+VGDV F+ +AS ITP Sbjct: 305 IMNADIVISAAGHPKLVRN--VKQGAIVIDVGISQGEKKGKIVGDVDFDVVKNQASLITP 362 Query: 259 VPGGVGPMTVATLIEN 274 VPGGVGPMTV L+ N Sbjct: 363 VPGGVGPMTVCMLMRN 378 >UniRef50_Q189R8 Methenyltetrahydrofolate cyclohydrolase n=26 Tax=Bacteria RepID=FOLD_CLOD6 Length = 290 Score = 179 bits (453), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 98/277 (35%), Positives = 154/277 (55%), Gaps = 2/277 (0%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +II GK +A ++ E+ ++V + G+ P L +V VG+ Y K C+ +G Sbjct: 9 QIIKGKPVADKISEELIKEVDLLVKEGIN-PKLTIVRVGARSDDLSYERGALKRCQNIGI 67 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + +L E ++ E ++++ +N D ++GIL PLP ++ + I P+KDVD F Sbjct: 68 TTEVLELAEDITQEEYIDVLKRVNDDKNVNGILCFRPLPKHLNEEVIKYVIAPEKDVDCF 127 Query: 124 HPYNVGRLCQ-RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 P N ++ + PCTP +V +L+ YN+D G V+G S +VG+P+SM LL Sbjct: 128 SPINSAKVMEGDKSGFPPCTPTAVVEILKHYNVDLKGSKVTVLGRSMVVGKPVSMLLLSE 187 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T T+ H TKNL AD+LI A+G+ + ++K+GA+VIDVGIN E G + G Sbjct: 188 HATVTICHSKTKNLSGVAAEADVLIAAIGRAKMVDESFVKDGAVVIDVGINVDEEGNLCG 247 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 DV + S ITPVP GVG +T + L ++ ++AC Sbjct: 248 DVDTNAVLDKVSMITPVPAGVGSVTTSILAKHVVKAC 284 >UniRef50_C1MLD7 5,10-methylene-tetrahydrofolate dehydrogenase/cyclohydrolase n=1 Tax=Micromonas pusilla CCMP1545 RepID=C1MLD7_9CHLO Length = 405 Score = 178 bits (452), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 121/352 (34%), Positives = 168/352 (47%), Gaps = 75/352 (21%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A+ +DG+ A + E+A + R PGLA ++VG+ P S +YV K +AC++ G Sbjct: 56 ARHLDGRQHAIRWMREIAISA----SRNPRPPGLAAIVVGNRPDSLLYVRRKGEACKKTG 111 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 LP + ++ +++ LN+D IDGILVQLP+P I K+LE I P+KDVDG Sbjct: 112 IHFYLIHLPGDIRQGKVRQILRRLNSDKNIDGILVQLPMPPQITENKLLECISPEKDVDG 171 Query: 123 FHPYNVGRLCQRA---PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 HP NVGRL R P PC P G + LL R I+ VIG SNIVG P+S L Sbjct: 172 LHPKNVGRLSARGTWRPVFMPCAPLGCMELLWREKINVKKKAVTVIGDSNIVGMPLSWLL 231 Query: 180 LLAGCTT-TVTH--------RFTK----------------NLRHHVENADLLIVAVGKPG 214 AG ++ T+ H +F+ + H + AD++I AVG G Sbjct: 232 RDAGASSVTILHSRAIWFLDKFSTAGSDDSQLCEDKPLQAQILHSLCEADVVIAAVGSVG 291 Query: 215 FIPGDWIKEGAIVIDVGINR---------------------------------------- 234 + +WIKEGA V+D+GIN Sbjct: 292 LVKREWIKEGATVVDIGINAVPDCHESVIFTGISPQKDCVNVCSSVTAMQRDAQQSFRSV 351 Query: 235 ---LENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 L N K++GDV E+ + A +T VPGG GPMT+A L+ NT + H Sbjct: 352 PQPLRNFKILGDVAAEEVSHVAGAMTSVPGGAGPMTIAALLSNTCLSASRKH 403 >UniRef50_B2KB67 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Elusimicrobium minutum Pei191 RepID=FOLD_ELUMP Length = 288 Score = 178 bits (451), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 101/283 (35%), Positives = 159/283 (56%), Gaps = 14/283 (4%) Query: 5 IIDGKTIAQQVRSEV---AQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 I++GKT+A +R + AQ + ++ L+ G+ ++ AS +Y+ + KA E+ Sbjct: 2 ILEGKTLAAAIRENLPARAQICKTKLGRPLKLTGIGW---AADYASYVYLDKEIKAAEKT 58 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G D+ E TS E+L +I L+ D T+D ++V PLP ++ +++ E ++P KD+D Sbjct: 59 GITGEVIDITEQTSHEEMLNIIKKLSTDETVDAVIVPKPLPRHLNTLEIWEALNPLKDID 118 Query: 122 GFHPYNVGRL--CQRAPRLR------PCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGR 173 G N+GRL C+ + P T ++ LL+ Y I G+ V+G S VG+ Sbjct: 119 GSSVLNMGRLFMCKNWAEVEAMQGFAPATAMAVIKLLDFYKIKLSGVETGVLGRSATVGK 178 Query: 174 PMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGIN 233 P++ L T + H T +L + D++I A+GK F+ + +K GA+VIDVG N Sbjct: 179 PLAHMLSCKDATVKICHSKTPSLTSSLSQCDIVISAIGKAKFVTENMVKTGAMVIDVGTN 238 Query: 234 RLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 + ENG GDV FE+ K S ITPVPGGVGP+T+A L+EN + Sbjct: 239 QDENGVFCGDVDFENVKKITSAITPVPGGVGPVTLACLLENII 281 >UniRef50_B5YA73 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Dictyoglomus RepID=FOLD_DICT6 Length = 283 Score = 178 bits (451), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 104/283 (36%), Positives = 160/283 (56%), Gaps = 3/283 (1%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I++GK +A+++ E+ +K++ G+ P L +V VG N ++ Y S + +G Sbjct: 4 ILEGKPVAEKLEKEIKEKIEIYKTKGI-IPNLCIVKVGENEEAEAYAKSIERFFSRIGIN 62 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + E S E + + L +N + GIL+ PL ++ K + PDKDV+G Sbjct: 63 VERKNFAENVSLLEFQKALKELEKNNKVHGILILRPLSEELERQKAFRFLSPDKDVEGIT 122 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 N+G+L PCTP+ ++ LL+ Y I G + VV+G S VG+P+S+ LL Sbjct: 123 YENLGKLFVGEKCFHPCTPQAVIELLDFYKISVEGKDVVVVGRSISVGKPLSILLLNRNA 182 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+ H TKNL A++L+ AVG+P FI D +KEG +VID+G N +E GK+VGDV Sbjct: 183 TVTICHSKTKNLEELTRRAEVLVAAVGRPHFIGKDMVKEGQVVIDIGTNVVE-GKLVGDV 241 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQD 287 FE+ + YITPVPGG+G +T L N L+A VE ++ ++ Sbjct: 242 NFEEVKDKVGYITPVPGGIGIITTRVLAMNLLKA-VEKNEARN 283 >UniRef50_D1C3C2 Methylenetetrahydrofolate dehydrogenase (NADP(+)) n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C3C2_SPHTD Length = 286 Score = 177 bits (450), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 103/275 (37%), Positives = 157/275 (57%), Gaps = 4/275 (1%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 ++G+ +A+ + +++ + P LA VL G + ++ YV + + + VG Sbjct: 5 LEGRPVARAILERAREELAEYVTQAGHPPELATVLAGDDASAAAYVRAIHRTFDRVGIPV 64 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 R LP +E+EL + ++ LNAD + GI++ PLP + + + P KDVDG P Sbjct: 65 RDVTLPGDVAESELRDAVERLNADPAVSGIIILHPLPRHLPAGIASQLVDPAKDVDGVTP 124 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCT 185 Y+ GRL P L P TP G + +LE Y I+ G +AVVIG S +VG PM++ L+ A T Sbjct: 125 YSAGRLAVGLPALPPSTPEGGMAILEHYGIEIAGSHAVVIGRSPVVGLPMALMLIAADAT 184 Query: 186 TTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVV 245 TV H T +L AD+L+ A G+PG + + +K GA VID G++ +G++VGDV Sbjct: 185 VTVCHSRTPDLPAMTRQADILVAAAGRPGLVRPEMVKPGATVIDFGVS-FVDGRMVGDV- 242 Query: 246 FEDA-AKRASYITPVPGGVGPMTVATLIENTLQAC 279 E A + A +TPVPGG G +T A L++NTL+A Sbjct: 243 -EPAVGEVAGALTPVPGGTGAVTNAILVQNTLRAA 276 >UniRef50_Q0SFQ8 Methenyltetrahydrofolate cyclohydrolase n=11 Tax=Actinomycetales RepID=FOLD1_RHOSR Length = 297 Score = 175 bits (444), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 103/286 (36%), Positives = 154/286 (53%), Gaps = 2/286 (0%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 + + G +A +R++ + A G R P LAVV + ++ YV S A + G Sbjct: 3 RSLGGAELATSIRNDASVAAAALNDLGTR-PKLAVVQATDDESTAWYVRSIASAAKRTGI 61 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + DL S ++ + L D + GI++Q PLP G D + E I+P KDVDG Sbjct: 62 LCDIVDLGAAASTEQIRSTLVELGHDPDVHGIILQTPLPDGTDLDALREAINPAKDVDGA 121 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 +P ++GRL R P P T + ++ LL+ + I A V+G S +VG P++ L+ Sbjct: 122 NPVSLGRLVARLPAFAPATAQAVIALLDHHGISPHARTATVVGRSTVVGSPVAHLLVQRN 181 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T TV HR T +L +AD+L+VAVG PG I D + +GA+VIDVG +G+++GD Sbjct: 182 ATVTVCHRHTTDLAAGTRDADILVVAVGIPGLITADHVADGAVVIDVGTTATADGQLLGD 241 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC-VEYHDPQDE 288 V RA +TPVPGGVGP+T A L+ +T+ A +Y + E Sbjct: 242 VDAAAVDGRAGALTPVPGGVGPVTTALLLNHTVDAAGTQYAQTRSE 287 >UniRef50_UPI00006CB712 tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain n=1 Tax=Tetrahymena thermophila RepID=UPI00006CB712 Length = 377 Score = 175 bits (444), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 102/272 (37%), Positives = 159/272 (58%), Gaps = 13/272 (4%) Query: 14 QVRSEVAQKVQARIA-AGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPE 72 ++ +V QKV+ RI +R P LA++LVG+ S YV+ K++AC+ VG S LPE Sbjct: 35 KISKDVLQKVKERILRVNIREPKLAIILVGNAADSISYVSVKQRACKRVGVQSELIHLPE 94 Query: 73 TTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLC 132 TT++ E++++++ LN +D IL QLP PA I V+ +I P KDVDG + + Sbjct: 95 TTTQKEVIQIVEDLNKREDVDSILTQLPFPAQISKTIVINQIEPSKDVDGLQRCFLTQQL 154 Query: 133 ---QRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVT 189 R PCTP+ + +L+ + ID G V++G +VG P+ LL G ++ Sbjct: 155 IWDDHNNRALPCTPQSCLHILDTHKIDVKGKQVVMLGKGLLVGSPLGAILLGRGAIVSMC 214 Query: 190 HRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINR----LENGKVVGDVV 245 + + +L +++AD+L+ A G + G+ +K+G IVIDVG +R + +VGDV Sbjct: 215 DKKS-DLSIALKDADILVSATGVRKLVKGEQLKKGVIVIDVGCSRPLPHEDQSSIVGDVE 273 Query: 246 FEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 FE AS +TPVPGGVGP+TV+ LI+N ++ Sbjct: 274 FES----ASLLTPVPGGVGPVTVSMLIQNVVK 301 >UniRef50_D1BP88 Tetrahydrofolate dehydrogenase/cyclohydrolase n=4 Tax=Veillonellaceae RepID=D1BP88_VEIPT Length = 275 Score = 172 bits (437), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 98/276 (35%), Positives = 152/276 (55%), Gaps = 7/276 (2%) Query: 8 GKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRS 67 GK +A ++ + +KV A G +AV+LVG + + +Y K + G+ Sbjct: 6 GKAVADAHKAILQEKVAA---VGNSVITMAVLLVGEDHGAHMYATFMEKTAKNFGYGFVL 62 Query: 68 YDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYN 127 LP+T ++ E++ + LN D +I GIL +P+P ID +++ + P KD+DG YN Sbjct: 63 KQLPKTATQDEVVAALHELNTDASIHGILPLMPMPKHIDTEALIDMLDPKKDIDGLTTYN 122 Query: 128 VGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTT 187 +G + PCT + + +L YNI + VV+G S ++G+P+++ L A T T Sbjct: 123 IGLVTAGKGGFAPCTAKACMAILNHYNISVEEKHVVVVGRSQVIGKPIALMALSAHGTVT 182 Query: 188 VTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFE 247 + H T +L V+ D++I A G+ I + IK GA+VIDVGIN L+ GK VGDV ++ Sbjct: 183 MCHSRTPDLAEQVKRGDIVIAAAGRAHMITANMIKPGAVVIDVGINELD-GKTVGDVDYD 241 Query: 248 DAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 AS ITPVPGGVG +T ++E +A YH Sbjct: 242 AVKDIASAITPVPGGVGSVTTTMMLEAVYEA---YH 274 >UniRef50_A4X776 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=Bacteria RepID=FOLD1_SALTO Length = 306 Score = 172 bits (435), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 102/278 (36%), Positives = 158/278 (56%), Gaps = 7/278 (2%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A+ + G +A+Q+ +EVAQ+V AAG+ P LA VLVG + AS Y+ K++ ++G Sbjct: 8 ARSLPGGPVAEQILAEVAQEVTQLRAAGV-TPALATVLVGDDDASVGYIRIKQRQAVQLG 66 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 F S LP + S+A+L ++ L+AD ++ G+LVQ P+P +D + ++ + P+KDVDG Sbjct: 67 FASPHVRLPASASQADLQAVVTQLSADTSVHGVLVQHPVPPHLDFDRAMQALDPEKDVDG 126 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL-- 180 HP N+GRL P PCTP GI LL + + G VV+G +GRP++M L Sbjct: 127 MHPVNLGRLALGLPGPTPCTPAGIEALLAYHEVPVAGREVVVLGRGATLGRPLAMVLAQK 186 Query: 181 --LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 A TV H + + A++++ A G PG + + ++ GA+V++ G+ R Sbjct: 187 RPTANAAVTVVHTGVPDWPRYTRRAEIVVAAAGVPGLVRPEHLRPGAVVVNGGV-RYAGR 245 Query: 239 KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 +++ D V E A A +TP GGVGP TVA L N + Sbjct: 246 RLLPD-VDESCATVAGAMTPRVGGVGPTTVAMLFRNAV 282 >UniRef50_A8RJW5 Putative uncharacterized protein n=2 Tax=Clostridium bolteae ATCC BAA-613 RepID=A8RJW5_9CLOT Length = 281 Score = 170 bits (430), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 99/278 (35%), Positives = 146/278 (52%), Gaps = 8/278 (2%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLR--APGLAVVLVGSNPASQIYVASKRKACEEV 61 KI+ G ++ +++ +V Q ++ GL AP LA+V VG P Y K E Sbjct: 2 KILKGAEVSAKIKEQVTQMME-----GLEGPAPKLAIVRVGEKPDDMSYERGAVKKMENF 56 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G ++Y PE S+++ +N D + GIL+ PLP I + + I P+KD+D Sbjct: 57 GLRVQTYVFPEQISDSDFKAEFSAINRDPDVSGILLLRPLPKQIAETDIEKMIDPEKDLD 116 Query: 122 GFHPYNVGR-LCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 G P N+ + PCT ++ +L+ ID G N ++G S +VGRP+SM +L Sbjct: 117 GISPANIAKVFAGDKTGFAPCTAEAVIEVLKANEIDMTGKNVTIVGRSMVVGRPLSMLML 176 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T T+ H T++L A++L+ A GK + G + + AIVIDVGIN ENGK+ Sbjct: 177 KENATVTICHTRTRDLETECRRAEILVAAAGKAKMLDGRHVGQDAIVIDVGINVDENGKL 236 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 GDV F AS TPVPGGVG +T A L ++ + A Sbjct: 237 CGDVDFPSIEPLASMATPVPGGVGAVTTAVLAKHLVLA 274 >UniRef50_C4XED5 Putative uncharacterized protein n=1 Tax=Mycoplasma fermentans PG18 RepID=C4XED5_MYCFE Length = 298 Score = 169 bits (429), Expect = 8e-41, Method: Compositional matrix adjust. Identities = 110/287 (38%), Positives = 161/287 (56%), Gaps = 12/287 (4%) Query: 4 KIIDGKTIAQQVRSE-VAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 KI+DGKT+AQ+ E +AQ + G R P L+++ VG NPAS Y+ +K K EE+G Sbjct: 15 KILDGKTLAQKRTKELIAQFKDIKEKLG-RKPILSIIQVGDNPASTHYIKNKLKKAEELG 73 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 + + P + +LL+ +D +N + DGI++QLPLP +L+ + +KD+DG Sbjct: 74 VEAIHHHFPADIRQKDLLKKLDIINEKS--DGIVIQLPLPKEFATQVILDSVRIEKDIDG 131 Query: 123 FHPYNVGRLCQRAP--RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 N +A L P T GI+ LL YNI A VIG S++VG+P + L Sbjct: 132 LCTRNAFNFYNQADDFTLVPATAIGILDLLNSYNIKMIDKKAAVIGRSSLVGKPTAFLLK 191 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE-NGK 239 GC + +R T VENAD+++VA G+ + + IKEGA+V+DVG N +E +GK Sbjct: 192 QEGCNVSTYNRNTG--IKGVENADIIVVAAGEAKLLKKENIKEGAVVVDVGSNWIEVDGK 249 Query: 240 VV--GDVVFEDAAKRA-SYITPVPGGVGPMTVATLIENTLQACVEYH 283 + GDV E + S + PVPGGVGPMTV +L N ++ + H Sbjct: 250 KILHGDVDIETIPENYLSALAPVPGGVGPMTVISLFTNLAKSIIHIH 296 >UniRef50_C6LCK2 Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase n=7 Tax=Bacteria RepID=C6LCK2_9FIRM Length = 282 Score = 169 bits (428), Expect = 9e-41, Method: Compositional matrix adjust. Identities = 95/272 (34%), Positives = 150/272 (55%), Gaps = 4/272 (1%) Query: 11 IAQQVRSEVAQKVQARIAAGLRA---PGLAVVLVGSNPASQIYVASKRKACEEVGFVSRS 67 + ++V + + ++++A +AA P LA++ VG NP+ Y K CE +G Sbjct: 6 LGKEVTAALNERIKANVAACQEKGVNPTLAIIRVGENPSDISYEKGATKRCETLGVACEK 65 Query: 68 YDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYN 127 LPE ++ ELL +ID +N D+ I G+L+ PLP +D + + +KDVD + Sbjct: 66 ILLPEDVAQEELLAVIDKVNKDDKIHGVLLFRPLPKHLDQAVIENALAAEKDVDCMTDLS 125 Query: 128 V-GRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTT 186 + G + PCTP+ + +L+ Y ID G AVVIG S +VG+P +M L+ T Sbjct: 126 MSGVFTGKKIGFPPCTPQACMEILDHYGIDCTGKKAVVIGRSLVVGKPAAMMLVKKNATV 185 Query: 187 TVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVF 246 T+ H T ++ AD++IVA G+ G + +++KEG +IDVGIN GK+ GDV + Sbjct: 186 TICHTRTVDMPSVAREADIIIVAAGRAGVVGAEYVKEGQTIIDVGINVNAEGKLCGDVDY 245 Query: 247 EDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 ITPVPGGVG +T + L+ + ++A Sbjct: 246 AAVEPIVDAITPVPGGVGSVTTSVLVGHVVEA 277 >UniRef50_Q4RT28 Chromosome 12 SCAF14999, whole genome shotgun sequence n=1 Tax=Tetraodon nigroviridis RepID=Q4RT28_TETNG Length = 342 Score = 168 bits (425), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 96/233 (41%), Positives = 133/233 (57%), Gaps = 15/233 (6%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A +I G+ +A+Q+R E V+ + G R P L+VVLVG +PAS YV +K +A ++G Sbjct: 30 AVVISGRKLARQIREEARADVEKWVLTGHRRPHLSVVLVGDDPASHSYVLNKTRAAADIG 89 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 S + SE ELL+LID LN D+ +DG+LVQLPLP ID + + P KDVDG Sbjct: 90 ISSETILKHSDISEEELLDLIDKLNTDHRVDGLLVQLPLPEHIDERTICNAVAPTKDVDG 149 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 FH NVGR+C + P TP G+ +++R I T G N VV G S VG P++M L Sbjct: 150 FHVVNVGRMCLDQSSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 209 Query: 183 G--------CTTTVTHRFT--KNLRHHVENADLLIVAVG---KPGFI--PGDW 220 G T T++HR+T + L H + AD++I A G K G++ P W Sbjct: 210 GRHERPGGDATVTISHRYTPKEQLCQHTKIADIVIAAAGLCKKEGWLHHPSTW 262 >UniRef50_C4Z3I2 Methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase n=3 Tax=Clostridiales RepID=C4Z3I2_EUBE2 Length = 280 Score = 167 bits (424), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 94/246 (38%), Positives = 135/246 (54%), Gaps = 1/246 (0%) Query: 34 PGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTID 93 P LA+V VG P Y K E+VGF SY P + D +N D ID Sbjct: 29 PHLAIVRVGERPDDMSYERGATKKMEKVGFRCTSYTFPADIDNDTFQKEFDKINEDEDID 88 Query: 94 GILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPR-LRPCTPRGIVTLLER 152 GIL+ PLP +D + RI KD+DG P N+ ++ P PCT ++ +L+ Sbjct: 89 GILLLRPLPKHLDEKAIENRIASVKDLDGISPMNLAKVYAGDPTGYGPCTAEAVIEMLDY 148 Query: 153 YNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGK 212 +D G AVVIG S ++G+P++M L+ T TV H T ++ + A++L+ A G Sbjct: 149 AGVDLKGKRAVVIGRSLVIGKPVAMMLMKKNATVTVCHTKTVDMPGVCKGAEVLVAAAGV 208 Query: 213 PGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLI 272 + ++ +GA+VIDVGIN E+G + GDV FED A+ AS TPVPGGVG +T + L Sbjct: 209 AKMVDKSFVADGAVVIDVGINVDEDGNLCGDVDFEDVAENASVCTPVPGGVGSVTTSVLA 268 Query: 273 ENTLQA 278 ++ L+A Sbjct: 269 KHLLKA 274 >UniRef50_C7N2I9 Methenyltetrahydrofolate cyclohydrolase /5,10-methylenetetrahydrofolate dehydrogenase (NADP+) n=7 Tax=Bacteria RepID=C7N2I9_SLAHD Length = 284 Score = 167 bits (423), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 101/278 (36%), Positives = 151/278 (54%), Gaps = 3/278 (1%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A+I+ GK +A + ++A +++A AAG+ P LA++ VG Y K E +G Sbjct: 2 AEILYGKPVADAINEKLAPRIEALKAAGV-TPQLAILRVGERDDDLSYERGAIKRFEALG 60 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 R + LPE S++ELL ++D +N D +I G L+ PLP +D E + P+KD DG Sbjct: 61 LDCRRFVLPENCSQSELLNVVDWINKDESIHGCLMFRPLPKHLDEAAACEALAPEKDADG 120 Query: 123 FHPYNV-GRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 ++ G R PCT + +L Y + G V+G S ++G+P+SM L Sbjct: 121 ITEGSLFGVFANRPVGFPPCTADACMKVLSHYGYELTGAKLAVVGRSLVIGKPVSMMLQA 180 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE-NGKV 240 A T T+ H TK+L AD+L+VA G G + ++EG +VIDVGIN + GK+ Sbjct: 181 ANATVTMCHTRTKDLSAACREADILVVAAGHIGTVGASEVREGQVVIDVGINWDDAAGKL 240 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 GDV F++ + ITPVP GVG +T A L E+ + A Sbjct: 241 CGDVTFDEVEPVVAAITPVPRGVGSVTTAVLAEHVVTA 278 >UniRef50_UPI00003BDED9 hypothetical protein DEHA0E19294g n=2 Tax=Debaryomyces hansenii CBS767 RepID=UPI00003BDED9 Length = 276 Score = 166 bits (421), Expect = 7e-40, Method: Compositional matrix adjust. Identities = 91/240 (37%), Positives = 134/240 (55%), Gaps = 16/240 (6%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKV---QARIAAGLRA-----------PGLAVVLVGSNPA 46 + A ++ G +A+ +RS++A+K+ + L A P L ++ VG P Sbjct: 29 LDAAVVSGTLLAKSIRSKIAEKIVDYNTTNFSNLNASNINFDNLQFRPNLTIIQVGGRPD 88 Query: 47 SQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGID 106 S YV +K KA + +S E SE +LLE ID LN D ++G+L+QLPLP + Sbjct: 89 SSAYVKAKLKAAKSSNILSSLLKFDEDMSEEDLLEEIDRLNKDPKVNGLLIQLPLPKHFN 148 Query: 107 NVKVLERIHPDKDVDGFHPYNVGRLCQR--APRLRPCTPRGIVTLLERYNIDTFGLNAVV 164 + + +KDVDGF YNVG L ++ AP +PCTP GI+ L++ I G NAVV Sbjct: 149 ETLITNAVATEKDVDGFARYNVGELTKKGGAPMFKPCTPNGIMELIKTTGISLRGKNAVV 208 Query: 165 IGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEG 224 +G S+IVG P++ L CT T+ HR T +L V NAD+++ AVG P ++ DW+KE Sbjct: 209 LGRSDIVGTPVAAMLRNEDCTVTICHRHTYDLPSVVRNADIIVAAVGIPEYVKADWVKEN 268 >UniRef50_C6CV64 Methylenetetrahydrofolate dehydrogenase (NADP(+)) n=1 Tax=Paenibacillus sp. JDR-2 RepID=C6CV64_PAESJ Length = 284 Score = 166 bits (419), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 94/275 (34%), Positives = 146/275 (53%), Gaps = 2/275 (0%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 K++ K A QV + KV+ G++ P +A +LV +PAS Y +K+K E++G Sbjct: 3 KLLKAKEAADQVYEGIRTKVEKWKHNGIQ-PRMAAILVEGDPASAYYAGAKQKIAEKLGV 61 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + +E E+L+L++ LN D ++ GI+++LPLP + + + I P KDVDG Sbjct: 62 AFTLHAFTAEVAEEEILQLVNRLNNDPSVHGIMLELPLPRHLSASTIEKAISPLKDVDGV 121 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 P N L P TP+ + LL+ Y G N ++G VG P+ L Sbjct: 122 TPANKLATVTGDSGLYPATPQSCIRLLQHYGYTLEGKNVTLVGRGQTVGLPLFHMLQREN 181 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T TV H T ++ H+ +A++ VAVG+P + + + ++ID GIN GK+VGD Sbjct: 182 ATVTVCHSRTPDIASHLSHAEIAFVAVGRPNIVEQNMVHSDLVIIDAGINETPQGKMVGD 241 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 V D A+ ++PVPGGVG +T A L EN ++A Sbjct: 242 VAI-DVQSSAAAVSPVPGGVGTLTTAILYENLMKA 275 >UniRef50_Q8EV80 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Mycoplasma penetrans RepID=FOLD_MYCPE Length = 282 Score = 165 bits (418), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 94/255 (36%), Positives = 147/255 (57%), Gaps = 5/255 (1%) Query: 34 PGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTID 93 P +A+V + + AS YV+ K K E+G V + ++ +L++ I LN D++ID Sbjct: 30 PHMAIVKINDDAASDKYVSIKLKKAAELG-VKTTLISEGIKTQDDLIKQIHILNNDDSID 88 Query: 94 GILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRL--RPCTPRGIVTLLE 151 G ++QLPLP G D+ + E I +KD+DG + + R + +PCT GI+ +L+ Sbjct: 89 GYIIQLPLPKGFDSNVICEHIDVNKDIDGLSSFAISRNLANSNLFHPKPCTANGIIEILK 148 Query: 152 RYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVG 211 + N G +AV+I S IVG+P+ L T TV H T+NL+ + AD+++VA+G Sbjct: 149 QSNYSIEGKHAVIINRSMIVGKPLIGLFLENNATVTVCHTKTQNLKEMTKTADIVVVAIG 208 Query: 212 KPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATL 271 KP F+ D + A VID GI+ ++ GKVVGD +D + YITPVP GVG +TVA + Sbjct: 209 KPDFLTKDMVNPNAFVIDAGISVVD-GKVVGDAA-KDLQEYVKYITPVPNGVGRLTVAMI 266 Query: 272 IENTLQACVEYHDPQ 286 +N + E ++ + Sbjct: 267 FKNLMDLVKEKYNER 281 >UniRef50_Q1AVQ0 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Rubrobacter xylanophilus DSM 9941 RepID=FOLD2_RUBXD Length = 320 Score = 165 bits (417), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 113/298 (37%), Positives = 161/298 (54%), Gaps = 24/298 (8%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A++IDG+ IA +++ VA +V+ A G+R PGLA VLVG + A++ Y E Sbjct: 1 MGARVIDGRPIAGELKKRVASEVEGLAARGVR-PGLATVLVGEDYAARAYERRVGGLAAE 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G LP EA++L ++ LNAD + GILV PLP I V + P KD+ Sbjct: 60 LGCRYVCERLPREAEEADVLAVVGKLNADPRVSGILVLRPLPGHISEPAVFSALDPLKDI 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGL---------NAVVIGASNIV 171 + HP N G L PR P TP LL+RY ++ G VV+G SN V Sbjct: 120 EAVHPVNAGLLALGRPRYVPSTPAACFYLLDRY-LERSGRPPEEFYPRSTVVVVGRSNNV 178 Query: 172 GRPMSMELLLAGCTTTVT-----HRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAI 226 G+P ++ L A ++ +R + LR H AD LIVA G G I +++EG I Sbjct: 179 GKP-AVSLGFARGAAVISCDANAYRAGR-LREHTLKADALIVAAGVAGLIDESYVREGVI 236 Query: 227 VIDVGINRLEN----GK--VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 +DVGIN + + G+ +VGD+ F A++A +TPVPGGVGP+T L++NT+ A Sbjct: 237 AVDVGINPVADPGGSGRTLLVGDLDFGSVARKAEALTPVPGGVGPITDVWLLKNTVAA 294 >UniRef50_B7AQ13 Putative uncharacterized protein n=3 Tax=Bacteria RepID=B7AQ13_9BACE Length = 286 Score = 164 bits (416), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 96/266 (36%), Positives = 140/266 (52%), Gaps = 2/266 (0%) Query: 15 VRSEVAQKVQARIAA-GLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPET 73 V + + ++VQ R+A P LA++ VG P Y K G +SY PE Sbjct: 15 VSAAIKEQVQNRLAELDGYIPTLAIIRVGEKPDDISYEKGAMKKMASFGLNVQSYTFPED 74 Query: 74 TSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGR-LC 132 S+A E +NAD IDGIL+ PLP I + + I P KD+DG P N+ + Sbjct: 75 ISDALFKEEFAKINADKAIDGILMLRPLPKHICEKDIEKMIDPAKDLDGISPENIAKVFA 134 Query: 133 QRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRF 192 + PCT ++ +L+ YNI G V+G S +VG+P+SM + T T+ H Sbjct: 135 GDSTGFAPCTAEAVIEVLKAYNIPMQGKRVTVVGRSMVVGKPLSMLFVKENATVTICHTR 194 Query: 193 TKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKR 252 T +L+ A++L+ A G+ + + + A+VIDVGIN ENG++ GDV +E Sbjct: 195 TADLKAECSRAEILVAAAGRARMLDSAYAGKDAVVIDVGINVDENGRLCGDVDYESLEGI 254 Query: 253 ASYITPVPGGVGPMTVATLIENTLQA 278 AS TPVPGGVG +T A L ++ +QA Sbjct: 255 ASMATPVPGGVGAVTTAVLAKHLVQA 280 >UniRef50_B5Y9D1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=FOLD_COPPD Length = 273 Score = 164 bits (414), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 102/273 (37%), Positives = 149/273 (54%), Gaps = 12/273 (4%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A I+ GK +A + E+ + G+ + GS+ Y++ KA + + Sbjct: 2 ALIMKGKPVADAIYEELQPMTSLNLTLGI------IKYKGSDAGG--YLSGLSKAAQRLN 53 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 R + E EL + + + D+ + GIL+ P P + + + I P+KDVD Sbjct: 54 VQLR---VNEVEQFQELTQSVVVMGKDSQVHGILLLKPFPKEWNFRQASDLIPPEKDVDA 110 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTF-GLNAVVIGASNIVGRPMSMELLL 181 HP N+G+L Q L P TP+ ++++L+ YN+ G +A+VIG S VG P ++L+ Sbjct: 111 LHPVNLGKLAQGRGNLVPATPQAVLSILDFYNVLPLEGASALVIGRSEAVGLPAFLQLMQ 170 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 T TV H TK+L ADL++VAVGKP F+ D +KEGA+VIDVG N LE+GKVV Sbjct: 171 RNATVTVAHSRTKDLPSLSRQADLVVVAVGKPNFLTKDHVKEGAVVIDVGTNVLEDGKVV 230 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIEN 274 GDV E+ ITPVPGGVG +T A L +N Sbjct: 231 GDVDRENVEPLVRAITPVPGGVGSVTTACLFKN 263 >UniRef50_Q2JCX4 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=Frankia RepID=FOLD1_FRASC Length = 276 Score = 163 bits (412), Expect = 6e-39, Method: Compositional matrix adjust. Identities = 105/277 (37%), Positives = 153/277 (55%), Gaps = 6/277 (2%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +++DG+++A ++ V + + R+AA P LAVVL ++PA+ Y + +VG Sbjct: 2 RMLDGRSMAAEIGRYVVDEAE-RLAAAGVTPTLAVVLPTADPAAYSYAEIIERTAGKVGV 60 Query: 64 VSRSYDLPETTSE-AELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 L E E A +L+ IDT+ AD T+ GI+VQ PLP G+ + +V E I KDVDG Sbjct: 61 ---HCVLHEPKGEPAAILDTIDTVAADPTVHGIIVQTPLPGGLTSREVGEHIPTAKDVDG 117 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 +P ++GRL P P T +V +L R I G VIG +VG+P+S+ LL Sbjct: 118 MNPSSLGRLALGLPSFAPATAAAVVEILTRARIPMSGARVCVIGRGPVVGKPVSLLLLAE 177 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T T+ H TK L AD+++ A G P + +++ GA VIDVG E G+ VG Sbjct: 178 DATVTICHSRTKGLVSIAHEADIIVSATGHPRLVGAGFVRPGAAVIDVGTVVTETGQ-VG 236 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 DV + A +TPVPGGVGP+T L+ NT++A Sbjct: 237 DVDAAAVSSVAGALTPVPGGVGPVTTMLLLRNTIRAA 273 >UniRef50_B5RQK8 Methylenetetrahydrofolate dehydrogenase n=2 Tax=Borrelia RepID=B5RQK8_BORRA Length = 313 Score = 163 bits (412), Expect = 7e-39, Method: Compositional matrix adjust. Identities = 102/253 (40%), Positives = 142/253 (56%), Gaps = 12/253 (4%) Query: 35 GLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDG 94 L V+L ++PAS++YV+ K + +E+G L E + ++L LI+ N ++ DG Sbjct: 44 SLKVILANNSPASELYVSVKERVSKEIGINFNVIRLSENLHQDDILRLIEIENTNDYTDG 103 Query: 95 ILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPR-LRPCTPRGIVTLLERY 153 I+VQLPL ID +L I KDVDG N+G+L R PCT I+ +L Y Sbjct: 104 IIVQLPLANKIDVNMILNSILSIKDVDGLSFVNLGKLVSGDKRGFIPCTALAILKILFDY 163 Query: 154 NIDTFGLNAVVIGASNIVGRPMSMELLLAGC-----TTTVTHRFTKNLRHHVENADLLIV 208 I+ G VVIG S +VGR +S +L C T V H T NL +V+ AD++I Sbjct: 164 KIEISGKTVVVIGRSLLVGRAIS---ILLSCKPYNATVIVCHSKTVNLDFYVKQADVIIS 220 Query: 209 AVGKPGFIPGDWIKEGAIVIDVGINRLE---NGKVVGDVVFEDAAKRASYITPVPGGVGP 265 AVGKP I I VID+GI+R++ + +VGDV FE R +ITPV GGVGP Sbjct: 221 AVGKPKLIDASMIVGHPYVIDIGISRVDVNNSSVLVGDVDFEAVKDRVRFITPVIGGVGP 280 Query: 266 MTVATLIENTLQA 278 +TV L+ NT++A Sbjct: 281 VTVLMLMFNTIKA 293 >UniRef50_C7MLE6 Methenyltetrahydrofolate cyclohydrolase /5,10-methylenetetrahydrofolate dehydrogenase (NADP+) n=4 Tax=Coriobacteriaceae RepID=C7MLE6_CRYCD Length = 293 Score = 162 bits (409), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 92/266 (34%), Positives = 143/266 (53%), Gaps = 2/266 (0%) Query: 17 SEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSE 76 +E ++ A++ A P LA++ VG+ P Y RK CE G + +++L +++ Sbjct: 15 AEETDRLVAQVTAQGITPQLAIIRVGNRPDDISYERGARKRCEARGIAATTFELAAESTQ 74 Query: 77 AELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNV-GRLCQRA 135 EL+ I +N D I G L+ PLPA ++ + P KD+DG P ++ G Q Sbjct: 75 DELMTTIQHINDDPAIHGCLMLRPLPASLNEEAATAVLLPQKDIDGITPSSLFGVFAQET 134 Query: 136 PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKN 195 PCT + ++ +L+ Y G N VIG S +VGRP+S+ L T T+ H T+ Sbjct: 135 VGFAPCTAQAVIEVLDHYGAHLDGTNVCVIGRSLVVGRPVSLMLQKRNATVTMCHSHTRT 194 Query: 196 LRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINR-LENGKVVGDVVFEDAAKRAS 254 ++ AD+++ A+G+ I DW+ G +VIDVGIN K+VGDV F+ + + Sbjct: 195 IQQVCRQADIVVAAIGQAHTIDVDWVSPGQVVIDVGINWDSAASKLVGDVDFDSVEPKVA 254 Query: 255 YITPVPGGVGPMTVATLIENTLQACV 280 ITPVPGG+G +T A L ++ QA V Sbjct: 255 AITPVPGGLGAVTSAVLCKHLAQAAV 280 >UniRef50_Q979W3 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Thermoplasma RepID=FOLD_THEVO Length = 281 Score = 162 bits (409), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 98/285 (34%), Positives = 169/285 (59%), Gaps = 13/285 (4%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 MA K++ G+ IA++ E+ ++++ G+ +P L ++ VG+ A+ IY +K K ++ Sbjct: 1 MAVKLLKGEEIAEKKAEELKERIEK---MGV-SPRLVLLQVGNYSAATIYARAKIKRGKK 56 Query: 61 VG--FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDK 118 +G V Y E ++ EL+ I+ L+AD ++GI+V+ PLP ID +++ I K Sbjct: 57 IGADVVLEKY---EDLTKQELVRRIEELSADKDVNGIMVENPLPKTIDYYDIVKSIPYYK 113 Query: 119 DVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSME 178 DVD PYN G + L P T +V +L+ Y + A +I S +VGRP+SM Sbjct: 114 DVDALSPYNQGSIAINREFLVPATAMAVVDILKYYGYEK--TTATIINRSPVVGRPLSMM 171 Query: 179 LLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 +L T ++ H T ++R + + +++VAVG+PGF+ ++ E ++VIDVGIN +++ Sbjct: 172 MLNRDYTVSICHSKTPDIRSIAKASKIIVVAVGRPGFLDDTYVTESSVVIDVGINYVQD- 230 Query: 239 KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 KV+GD+ F+ +++ +TPVPGGVGP+T ++ N ++A EY Sbjct: 231 KVIGDIDFDKVSEKVEAVTPVPGGVGPITATNILSNLVKAA-EYQ 274 >UniRef50_Q6KID0 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Mycoplasma mobile RepID=FOLD_MYCMO Length = 280 Score = 161 bits (408), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 104/283 (36%), Positives = 151/283 (53%), Gaps = 15/283 (5%) Query: 5 IIDGKTIAQQVRSEVAQKV-QARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 I+DGK ++Q+ + +KV Q +I P +V VG+ +S Y+ +K E+G Sbjct: 3 ILDGKKLSQKDTIFLKEKVNQFKIK-----PVFTIVQVGNLFSSNKYIKTKMDKALEIGV 57 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 VSR +PE+ SE +L+ +I+ G++VQLPLP D K+L + KD+DG Sbjct: 58 VSRLIKIPESISEKDLISIIE--EESKISHGLIVQLPLPLQFDQSKILNSVPITKDIDGL 115 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 N L ++P T RGI+ L++ YN VIG SN+VG+P+ AG Sbjct: 116 SEKNSKNLYSGKSCIQPATARGIIDLIKEYNFTIKDKKVYVIGESNLVGKPIKELFKQAG 175 Query: 184 CTTTVTHRFTKNLR-HHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL-ENGK-- 239 + F N E AD+LIVA G P + + +K +IVIDVGIN + EN K Sbjct: 176 A---IVKSFNINTGIKGSEEADILIVAAGHPNLVKPENVKNNSIVIDVGINSIGENDKMI 232 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 V GDV F + + I+PVPGGVGPMTV +L +N ++ +Y Sbjct: 233 VTGDVDFSNVKTKVKAISPVPGGVGPMTVISLFKNLIEIFEKY 275 >UniRef50_UPI00003C8447 methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI00003C8447 Length = 281 Score = 161 bits (407), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 95/274 (34%), Positives = 155/274 (56%), Gaps = 4/274 (1%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 ++DGK +A + + +++ I P L ++ VG++PAS IY SK K ++G + Sbjct: 2 LLDGKVVASEKMERLKSEIKGIIEKYGIEPELKLIQVGNDPASTIYANSKIKRGTKLG-I 60 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + + + + + +L++ I NA++ I+GI+V+ PLP ++ +V++ I KD DG Sbjct: 61 NVTLEKFDNITMGKLVDYIKDANANSRINGIMVESPLPPSLNFQEVVDNISFYKDTDGMT 120 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 +N G L + + P T R +V +LE Y I NA +I S +VGRP++M LL Sbjct: 121 SFNQGNLYTKNEMIAPATARAVVDILEYYKIQPG--NACIINRSAVVGRPLAMLLLNRDY 178 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+ H T +++ ++L+VA+GKP +I ++ + VIDVGIN N K+ GDV Sbjct: 179 TVTLCHSKTVDIKRIARENNVLVVAIGKPDYIDESYVTSESTVIDVGINYSGN-KISGDV 237 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 F+ + +A ITPVPGGVG +T + EN L Sbjct: 238 NFDSVSNKAKNITPVPGGVGIVTATDIFENFLNG 271 >UniRef50_Q6L046 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Picrophilus torridus RepID=FOLD_PICTO Length = 276 Score = 161 bits (407), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 94/274 (34%), Positives = 154/274 (56%), Gaps = 6/274 (2%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 IIDG I++ + +++ G+ P + ++L+G++ S +Y +K + ++G + Sbjct: 2 IIDGVKISETKMERLKNEIEKIKNTGIN-PKMKIILIGNDYGSVVYSKAKMRRGSKLG-I 59 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 D ++ S +L++L+ + + I GI+++ P+P GI+ V+ I KDVDG Sbjct: 60 DVDLDRYDSISREDLIKLLKRYSQSDDIHGIMIETPVP-GINYYDVVNEIPFYKDVDGMT 118 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 YN+G L + + P T R +V +L+ NI + N +I S +VGRP+SM LL Sbjct: 119 SYNLGNLYLKNEFIAPATARAVVDILDYINIKSG--NVAIINRSPVVGRPLSMMLLNRDF 176 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T TV H T N+ ++D+++VAVGKP F+ ++ + I+IDVGIN L NGK GD Sbjct: 177 TVTVCHSRTVNINEITRSSDIVVVAVGKPNFLDRSYVSDKNIIIDVGINYL-NGKTCGDA 235 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 +E+ + ITPVPGGVGP+T + EN + Sbjct: 236 DYENIKDYVNAITPVPGGVGPVTATDIFENFING 269 >UniRef50_A7AXK7 Putative uncharacterized protein n=1 Tax=Ruminococcus gnavus ATCC 29149 RepID=A7AXK7_RUMGN Length = 276 Score = 160 bits (405), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 91/251 (36%), Positives = 143/251 (56%), Gaps = 14/251 (5%) Query: 32 RAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNT 91 + P LAV+ + + AS Y+ K+K C+E+G R ++ T+E + +E + T A + Sbjct: 28 KKPVLAVIQIDDDQASNSYIKGKQKDCDEIGIEMRHVNIYSNTTEQKEVECVITDIAKSD 87 Query: 92 IDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLE 151 DGI++QLP+P + ++ I P+KDVDGF ++ +PCTP+GI+ +E Sbjct: 88 ADGIIIQLPIPDKYNLERLQHLIPPEKDVDGF---------RKDSCFKPCTPKGIIDWME 138 Query: 152 RYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVG 211 N + G + V+G S IVG P++ L+ G T T + T + ++ NAD AVG Sbjct: 139 YNNFEFEGKDCCVLGRSKIVGLPLTNMLIEKGATVTCCNSTTPSTWYYTRNADYAFSAVG 198 Query: 212 KPGFIP-GDWIKEGAIVIDVGINRLENGKVVGDVV---FEDAAKRASYITPVPGGVGPMT 267 P + D+ +V+D+GINR ENGK+ GDV FE ++ +Y+TPVPGGVG +T Sbjct: 199 VPNYFDFSDFQDFCELVVDIGINRDENGKLCGDVNNAGFE-SSLNDTYVTPVPGGVGLLT 257 Query: 268 VATLIENTLQA 278 TL++N + A Sbjct: 258 RLTLMQNVVDA 268 >UniRef50_Q5IWX9 Plastid 5,10-methylene-tetrahydrofolate dehydrogenase (Fragment) n=1 Tax=Prototheca wickerhamii RepID=Q5IWX9_PROWI Length = 248 Score = 160 bits (404), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 90/189 (47%), Positives = 115/189 (60%), Gaps = 2/189 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A +IDGK IA+ +R E+ +V A PGLAVVLVG SQ YV SK+KAC+E Sbjct: 60 MPAALIDGKKIAETIRGELKVEVDELRAQYNTVPGLAVVLVGERKDSQTYVRSKKKACDE 119 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG S DLPET +E E+L ++ N D + GILVQLPLP I+ +VL+ I +KDV Sbjct: 120 VGINSFGADLPETATEEEVLAVVAKFNDDPNVHGILVQLPLPEHINEKRVLDAISLEKDV 179 Query: 121 DGFHPYNVGRLCQ--RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSME 178 DGFHP N+G L R+P CTP+G + LL+R + G A V+G SNIVG P ++ Sbjct: 180 DGFHPNNIGELAMRGRSPTYVSCTPKGCLELLKRAGVTLAGKRAAVVGRSNIVGLPAALL 239 Query: 179 LLLAGCTTT 187 L T T Sbjct: 240 LQQEDATVT 248 >UniRef50_B9KZ23 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=FOLD_THERP Length = 288 Score = 159 bits (403), Expect = 8e-38, Method: Compositional matrix adjust. Identities = 100/267 (37%), Positives = 152/267 (56%), Gaps = 4/267 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 MAA I+ G+ + + + + + Q+V AR A P L VL+ ++P++Q Y + RK Sbjct: 1 MAAHILSGRPVVESLHARI-QQVLARRAPHQGPPTL-TVLLPNDPSAQAYARAIRKQFTT 58 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 + R+ ++ +T E+ L+ L D ++ GIL PLP G+ + + P KDV Sbjct: 59 LSLNYRTEEIDDTLDESRFAILLKRLAEDESVTGILALQPLPKGVSRRSLARLMPPTKDV 118 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG GRL +P + P TP G + LL+ Y I+ G +AVVIG S +VGRP+++ LL Sbjct: 119 DGVSFEQQGRLAIGSPWIAPSTPLGGLILLQHYGIEVAGRHAVVIGRSPVVGRPLALLLL 178 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T T+ HR T +L ADLL VA G+P + D + GA+VID G++ + +G++ Sbjct: 179 ARDATVTICHRRTPDLAKLTRQADLLFVAAGQPHLVKPDMVAPGAVVIDFGVS-VRDGRL 237 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMT 267 +GD V A+ AS +TPVPGG GP+T Sbjct: 238 IGD-VDPAVAEVASALTPVPGGTGPVT 263 >UniRef50_D1J7X9 Methylenetetrahydrofolate dehydrogenase n=1 Tax=Mycoplasma hominis ATCC 23114 RepID=D1J7X9_MYCHP Length = 292 Score = 159 bits (402), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 98/280 (35%), Positives = 162/280 (57%), Gaps = 11/280 (3%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A +++GK I+ +V+ ++ + ++ ++ +R P L ++ VG S IYV +K K ++G Sbjct: 2 AILLNGKAISLKVKEDLKKAIE-KMPQEIR-PTLGILQVGDLSESNIYVKNKLKYASDIG 59 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAG--IDNVKVLERIHPDKDV 120 ++ L + S+ ++ E I+ LN +T G +VQ+P+ ID+ ++L+ I D D+ Sbjct: 60 LNTKLIKLQQNASKLQIAEAIELLNKQST--GFIVQIPMQTNQIIDSQEILDLISIDHDI 117 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG +N+ L T GI LL +YNI VIG S IVG P++ L+ Sbjct: 118 DGLTSFNLD-LKNPNNYFLSATASGIFLLLNKYNILYKNAKIGVIGQSKIVGYPLANFLV 176 Query: 181 LAGCTTTVTHRFTKNL-RHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGK 239 L G R+ K+ ++++++ D++IVA G I D +K GA++IDVGI+R N K Sbjct: 177 LKGYNV---FRYNKDTPKNNIKDLDIIIVATGTKDPITYDQVKPGAVIIDVGIHRDSNNK 233 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 + GD+ F + + AS+ITPVPGGVGPMT++ L+ N L+A Sbjct: 234 ISGDLNFNEFSNVASFITPVPGGVGPMTISALLINLLKAS 273 >UniRef50_B3PMJ8 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Mycoplasma arthritidis 158L3-1 RepID=FOLD_MYCA5 Length = 293 Score = 159 bits (402), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 100/281 (35%), Positives = 161/281 (57%), Gaps = 15/281 (5%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+DGK +++ +++++A A P L ++ VG+ S IYVA K K E +GF+ Sbjct: 4 ILDGKRLSEALQAKIAMAFSAYRGP---KPILGILQVGNKEDSNIYVAHKLKVAESLGFL 60 Query: 65 SRSYDLPETTSEAELLELIDTL-NADNTIDGILVQLPLPAG-IDNVK-VLERIHPDKDVD 121 ++ +PE +++ E+ I TL NA + GI+VQLPL + I+N++ +L+ I +KD+D Sbjct: 61 TKLVKMPENSTQDEI---IGTLRNAAAEVTGIIVQLPLVSNRIENLQEILDNIPIEKDID 117 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G YN+ TP+GI+ LL+ YNI+ ++G SNIVG+P++ L Sbjct: 118 GLSSYNLASNYNCKDNFLSATPKGIILLLKHYNINFRSTVIALVGQSNIVGKPLAK--YL 175 Query: 182 AGCTTTVTHRFTKNL-RHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 + + K+ + + A ++IVA G + D + G ++IDVGI+R GK Sbjct: 176 SNFKNNTIKTYVKDTPKDDLHEAKIVIVATGVYQSVTADQLANGTVLIDVGIHR--QGKT 233 Query: 241 V-GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 + GD+ F K+ASYITPVPGGVGP+TV L+ N ++A + Sbjct: 234 IHGDLDFASCFKKASYITPVPGGVGPLTVVALMFNLIKALI 274 >UniRef50_C2L112 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Oribacterium sinus F0268 RepID=C2L112_9FIRM Length = 281 Score = 159 bits (402), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 94/272 (34%), Positives = 139/272 (51%), Gaps = 4/272 (1%) Query: 8 GKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRS 67 GK +A+++ E + R P LA++ VG A Y + +K G +S Sbjct: 6 GKPVAEEIEKECVAFLAERPGV---MPALALIRVGERTADVTYEKAIKKRFLSFGLEVKS 62 Query: 68 YDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYN 127 Y LP S + E+I LN D I GI+V PLP+ +D I +KDV+G N Sbjct: 63 YQLPADCSNEQFQEVIQFLNGDEEIHGIMVFRPLPSHLDQETAFRMIKREKDVEGVSREN 122 Query: 128 V-GRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTT 186 + G + + PCT + ++ + Y I G ++G S +VGRP+S+ + T Sbjct: 123 MAGLILKDESAFAPCTAQAVMEMCRFYKIPLAGKEVCILGRSLVVGRPLSILMTNKDATV 182 Query: 187 TVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVF 246 T+ H T N++ + AD+L+ +GK I + KEGA VIDVG NR E G +VGDV F Sbjct: 183 TLCHSKTSNIKEVTKRADVLVCCMGKAKAIGSSYCKEGATVIDVGTNRDEKGNLVGDVDF 242 Query: 247 EDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 + A A I+PVP G+G +T A L + L+A Sbjct: 243 DTMATVAEKISPVPRGLGAVTTAVLAKQLLKA 274 >UniRef50_C8WAB5 Tetrahydrofolate dehydrogenase/cyclohydrolase n=1 Tax=Atopobium parvulum DSM 20469 RepID=C8WAB5_ATOPD Length = 289 Score = 158 bits (400), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 96/273 (35%), Positives = 147/273 (53%), Gaps = 3/273 (1%) Query: 8 GKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRS 67 G +A+ + E+A +V+ A G+ P L +V +G Y + E+VGF + Sbjct: 12 GAPVAKAITEELAVQVEELRAEGI-IPRLVIVRIGQKSDDLTYERAAYMRAEKVGFEVET 70 Query: 68 YDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD-GFHPY 126 +LPE ++ ++ D ++AD ++ G L P PAGID + L+ + P+KDVD Sbjct: 71 IELPEDATQKQVNTTFDQVSADASVHGCLPMRPFPAGIDEHEALQHLTPEKDVDCATDSM 130 Query: 127 NVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTT 186 + LC L PCT ++ LL+ Y + G + V+G SN++GRP++ L T Sbjct: 131 LLATLCGTPGALGPCTAEAVLALLDFYQVPLEGASIAVVGRSNVIGRPVAALLSARNATV 190 Query: 187 TVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-KVVGDVV 245 TV H TK+L ++ AD+++VA G+ I D+++ G +IDVGIN E K+VGDV Sbjct: 191 TVCHSKTKDLAATLKQADVVVVAAGRAHLIGADYVRAGQTIIDVGINWDEAAQKLVGDVD 250 Query: 246 FEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 E A S TPVPGGVG +T A L + + A Sbjct: 251 TEQVAPLVSAYTPVPGGVGSVTTAILARHVVAA 283 >UniRef50_B9K850 Bifunctional protein folD n=1 Tax=Thermotoga neapolitana DSM 4359 RepID=B9K850_THENN Length = 284 Score = 157 bits (397), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 98/275 (35%), Positives = 156/275 (56%), Gaps = 14/275 (5%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 ID K+IA+ + +V ++V P L V+ +P++ Y+ S++K E++G Sbjct: 16 IDCKSIAKSIEEDVRKRVDLLSFT----PKLVSVVGTDDPSTASYLRSQKKKAEKLGI-- 69 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 +++ +T S + L ++ L D ++G+ V PLP G+D +V + +KDV+G +P Sbjct: 70 -DFEIIKT-SPGDFLSTLEKLAEDKNVNGVFVARPLPEGLDEKRVFSAVPVEKDVEGVNP 127 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG-- 183 N+G L PCT +V +LE + G ++G S VG+P+++ LL G Sbjct: 128 ENLGFLLYGEETFPPCTAEAVVKVLESVT-EISGKKVTIVGRSVTVGKPLAIMLLKKGRD 186 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T TV H T+NL +D+++VAVGK F+ D +KEGAIVIDVGIN + +GK GD Sbjct: 187 ATVTVCHSRTQNLGEITRASDIVVVAVGKAHFLKRDMVKEGAIVIDVGINYV-DGKWCGD 245 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 V + A + + +TPVPGGVG +T A L E+ ++A Sbjct: 246 V--DSAVEEIAQVTPVPGGVGQITTALLFEHVVRA 278 >UniRef50_C4QA37 Formate-tetrahydrofolate ligase, putative n=1 Tax=Schistosoma mansoni RepID=C4QA37_SCHMA Length = 335 Score = 157 bits (396), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 99/293 (33%), Positives = 148/293 (50%), Gaps = 23/293 (7%) Query: 8 GKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRS 67 G+ IAQ V ++ V + +P L VV VG+ P S++Y+ K K ++ G + Sbjct: 10 GQQIAQTVGQKIISDVAYLKSNFNISPKLVVVEVGNLPQSKLYIEQKSKFAKKYGILLSH 69 Query: 68 YDLPETTSEAELLELIDTLNADNTIDGILVQLPLPA--GIDNVKVLERIHPDKDVDGFHP 125 P E+ LL+ + LN+D+++ GI +QLP + I+ L + KDV+G +P Sbjct: 70 MRFPSHIPESVLLDYVYKLNSDSSVHGITLQLPFDSDSNINVTNPLNAVATLKDVEGLNP 129 Query: 126 YNVGRL---------CQRAPRLR---PCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGR 173 YN L C+ + PCT + N G V+IG +VG Sbjct: 130 YNTAVLSRGDILCPYCENVKQQHVHIPCTAAACYAFIRHVNFPIIGSRCVIIGGGRLVGA 189 Query: 174 PMSMELLLAGCTTTV--THRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVG 231 P + +LL C TV H + N+ + D++I AVG P I G+WIK GA+VID G Sbjct: 190 PTA-DLLSRSCGATVIQCHIQSNNINEEINRGDVVISAVGHPRLIKGEWIKPGALVIDCG 248 Query: 232 INRLEN------GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 + L + + VGDV FE A + A +ITPVPGGVGP+++A L NT+ + Sbjct: 249 YSVLNDPRNPNKSRCVGDVEFETAIENAKWITPVPGGVGPVSIAMLFRNTVNS 301 >UniRef50_C8WUM8 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WUM8_ALIAD Length = 285 Score = 156 bits (395), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 87/271 (32%), Positives = 145/271 (53%), Gaps = 2/271 (0%) Query: 8 GKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRS 67 G+ +A+ + +V + V+ + G++ P L +L + A+ +Y K++ E +G Sbjct: 7 GRPVAKALSHDVRKTVETWKSRGVQ-PKLVTLLANDDHAASVYANQKKRIAERLGIQCDV 65 Query: 68 YDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYN 127 +LP+ + ++ I LN D ++ GI++++PL +D +V+ IH KDVDG P + Sbjct: 66 IELPQQSDTEAIVRQIQALNDDPSVHGIMIEMPLAPSVDVQRVVGAIHALKDVDGLSPCH 125 Query: 128 VGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTT 187 L P TP + LL+ Y G + ++G VG P+ L+ G T Sbjct: 126 SFAKPTPEAALYPATPLACIRLLKHYGYQLKGADVTLVGCGQTVGMPLLHLLIAEGATVA 185 Query: 188 VTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFE 247 H T+++R H+ ++++ IVAVGK G + D + +G V+DVGI++ ENG V GD+ E Sbjct: 186 ACHEHTRDVRAHLRDSEIAIVAVGKGGLLGPDMVHDGLTVVDVGISQGENGDVQGDLAPE 245 Query: 248 DAAKRASYITPVPGGVGPMTVATLIENTLQA 278 AAK +Y TP PGGVG +T + N + A Sbjct: 246 AAAKTKAY-TPTPGGVGAVTTVQIFANLMHA 275 >UniRef50_A6LP88 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Thermosipho melanesiensis BI429 RepID=FOLD_THEM4 Length = 271 Score = 156 bits (394), Expect = 9e-37, Method: Compositional matrix adjust. Identities = 96/277 (34%), Positives = 158/277 (57%), Gaps = 14/277 (5%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 IID K + + ++ + + RI R P L V +P++ Y+ S+ KA + G Sbjct: 2 IIDVKPLYEDIKVNLLK----RIEKLKRTPKLVAVTFKPDPSTVSYLKSQEKAAKRFGL- 56 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 Y++ E S +L+++ L+ DN ++GI V PL + ++ +++ E + P KD++G H Sbjct: 57 --DYEIFEGNSPKGVLKILAELSRDNNVNGIFVTHPL-SQVNEMEIFENLVPSKDIEGRH 113 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA-- 182 PYN+G L PCT +V ++E I G N V++G SN VG+P+++ LL Sbjct: 114 PYNLGMLAYGEEFFAPCTAEAVVRIMEN-EIGIPGKNVVIVGRSNTVGKPLAIMLLRRDR 172 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T TV H T+NL + AD+++ A G+PG I D +++ +I+IDVGIN + G ++G Sbjct: 173 SATVTVCHTKTRNLSSITKGADVVVAAAGRPGLITVDMVEKDSIIIDVGINVTDEG-IIG 231 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 DV +D A A +TPVPGGVG +T L+E+ +++ Sbjct: 232 DVS-KDVANFAK-VTPVPGGVGKITTILLMEHLVKSA 266 >UniRef50_Q86F84 Clone ZZD1003 mRNA sequence n=2 Tax=Schistosoma japonicum RepID=Q86F84_SCHJA Length = 332 Score = 155 bits (392), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 98/295 (33%), Positives = 149/295 (50%), Gaps = 22/295 (7%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+ G+ +AQ V ++ V ++ P L V+ VG P S++Y+ K K ++ G + Sbjct: 6 ILYGRQVAQAVGHKIKLDVALLKSSFDVYPKLVVIEVGELPQSKLYIKQKFKFAKKYGIL 65 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPA--GIDNVKVLERIHPDKDVDG 122 LP SE+ LL+ + LNAD+++ GI +QLP + I+ L + KDV+G Sbjct: 66 LSHMRLPSHISESLLLDYVYKLNADSSVHGITLQLPFDSDTNINVTNSLNAVATHKDVEG 125 Query: 123 FHPYNVGRL-----CQRAPRLR------PCTPRGIVTLLERYNIDTFGLNAVVIGASNIV 171 + YN L RL+ CT L+ N G V+IG +V Sbjct: 126 LNSYNTALLSVVIYSATLRRLKTKTYSYTCTAAACYALIRHVNFPISGSRCVIIGRGRLV 185 Query: 172 GRPMSMELLLAGCTTTV--THRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVID 229 G P + ELL C TV H + N+ + D++I VG PG I GDW++ GA+VID Sbjct: 186 GAP-TAELLSGSCGATVIQCHLQSANIDEEINRGDIIISGVGHPGLIKGDWVRPGALVID 244 Query: 230 VGINRLEN------GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 G + + + + GDV F A ++A +ITPVPGGVGP+++A L NT+ + Sbjct: 245 CGYSVMNDPQNPSKSRCFGDVEFNTALEKAKWITPVPGGVGPVSIAMLFRNTVNS 299 >UniRef50_A5ILJ9 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=Thermotogaceae RepID=FOLD_THEP1 Length = 271 Score = 155 bits (391), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 96/275 (34%), Positives = 157/275 (57%), Gaps = 14/275 (5%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 ID +TIA+ + ++V+ G P L V +P++ Y+ S+RK E++G Sbjct: 3 IDCRTIARSIEERTKERVEK---LGF-TPKLVSVACTDDPSTLSYLKSQRKKAEKLGI-- 56 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 ++++ + E E++ + L +D +++G+ V P P D ++L + +KDV+G +P Sbjct: 57 -AFEILNVSPE-EIVSTLKKLGSDESVNGVFVARPFPPSFDEKEILSSVPVEKDVEGVNP 114 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG-- 183 N+G L PCT V +LER + G V+G S VG+P+++ LL G Sbjct: 115 ANLGLLLYDEEIFPPCTAEAAVRILER-ETNLSGKRVTVVGRSVTVGKPLALMLLKKGRD 173 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T TV H T NL +N+D+++VAVG+ F+ + +KEGAIVIDVGIN + +GK+ GD Sbjct: 174 ATVTVCHSRTVNLEEITKNSDIVVVAVGRAHFLKKNMVKEGAIVIDVGINYV-DGKLQGD 232 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 V + + + + +TPVPGGVG +T A L E+ ++A Sbjct: 233 V--DPSVEEIARVTPVPGGVGQVTTALLFEHVVRA 265 >UniRef50_A7HMQ2 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Fervidobacterium nodosum Rt17-B1 RepID=FOLD_FERNB Length = 272 Score = 152 bits (384), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 89/268 (33%), Positives = 149/268 (55%), Gaps = 9/268 (3%) Query: 13 QQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPE 72 + + S + + ++ R++ + P L V + ++ Y+ S+ K + G Y+ P+ Sbjct: 6 EPLYSSMVENIKERVSKLSKPPKLVAVTCQPDSSTLAYLRSQEKQAKRFGIDFAVYEAPK 65 Query: 73 TTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLC 132 +L L+ L+AD +++GI + PLP+ I + + I PDKD++G HP N+G + Sbjct: 66 AM---DLKILLPKLSADGSVNGIFLTHPLPSDISEYEAVSLISPDKDIEGRHPINLGNIL 122 Query: 133 QRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG--CTTTVTH 190 P PCT ++ ++ Y + G VIG S VG+P++M LL G T T+ H Sbjct: 123 YDKPVFPPCTAEAVLRII-NYLTNPSGKKIAVIGRSVTVGKPLAMLLLQKGIDATVTICH 181 Query: 191 RFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAA 250 TK++ +N+D+++VA+GK D+ K G IVIDVGIN +E ++VGDV + + Sbjct: 182 SRTKDIAEITKNSDIVVVAIGKAKMFGKDYFKPGTIVIDVGIN-VEGDEIVGDV--DPSV 238 Query: 251 KRASYITPVPGGVGPMTVATLIENTLQA 278 +TPVPGGVG +T L+E+T++A Sbjct: 239 SEICELTPVPGGVGRITTLVLMEHTVKA 266 >UniRef50_UPI000194D930 PREDICTED: methylene tetrahydrofolate dehydrogenase 2 n=1 Tax=Taeniopygia guttata RepID=UPI000194D930 Length = 299 Score = 151 bits (382), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 102/256 (39%), Positives = 128/256 (50%), Gaps = 59/256 (23%) Query: 27 IAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTL 86 +AAG R P L+VVLVG NPAS YV +K KA +VG S + P + SE ELLELI L Sbjct: 69 VAAGNRRPHLSVVLVGENPASHSYVLNKTKAAADVGISSETILRPASISEEELLELIAKL 128 Query: 87 NADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGI 146 N+D +DG+LVQLPLP ID +V + P KDVDGFH NVGR+C + P TPRG+ Sbjct: 129 NSDAAVDGLLVQLPLPEHIDERRVCNAVSPHKDVDGFHVLNVGRMCLDQDSMLPATPRGV 188 Query: 147 VTLLERYNIDTFGLNAVVIGASNIVGRPMSM---ELLLAGCTTTVTHRFTKNLRHHVENA 203 +++R I +S + RP S+ ELL L Sbjct: 189 WEIIQRTGI-----------SSETILRPASISEEELL----------ELIAKLNSDAA-V 226 Query: 204 DLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGV 263 D L+V + PG K+ASYITPVPGGV Sbjct: 227 DGLLVQLPLPGV----------------------------------RKKASYITPVPGGV 252 Query: 264 GPMTVATLIENTLQAC 279 GPMTVA L++NT+ A Sbjct: 253 GPMTVAMLMKNTIIAA 268 >UniRef50_D1VQM8 Methylenetetrahydrofolate dehydrogenase (NADP(+)) n=1 Tax=Frankia sp. EuI1c RepID=D1VQM8_9ACTO Length = 277 Score = 151 bits (382), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 104/276 (37%), Positives = 152/276 (55%), Gaps = 4/276 (1%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +++DG+ +A ++ V +V AG+ P LAVVL G + A+ + + VG Sbjct: 2 RLLDGRAMAAEIGRHVVDEVALLAEAGV-TPTLAVVLPGDDRAALSFARVIEQTAGRVGV 60 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + + L + EL E + L AD + GIL Q PLPAG+ +V RI KDVDG Sbjct: 61 ACQRHQL--SGKPDELTETLGRLAADPAVHGILAQTPLPAGMTADEVGARIPASKDVDGM 118 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 +P ++GRL P P T +V +L R ++ G A VIG S +VG+P ++ LL Sbjct: 119 NPTSLGRLALGLPAFAPATAAAVVEILRRGDVPMAGARACVIGRSPVVGKPAALLLLAED 178 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T TV H T++L AD+++ AVG+P + +++ GA VIDVG N + G +VGD Sbjct: 179 ATVTVCHSRTRDLATVAHEADIVVAAVGRPKLVGAGFVRPGATVIDVGTNVTDEG-LVGD 237 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 V + A A +TPVPGGVGP+T L+ NT+QA Sbjct: 238 VDADAIAGVAGALTPVPGGVGPVTTMLLLRNTVQAA 273 >UniRef50_Q160C0 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=Alphaproteobacteria RepID=FOLD3_ROSDO Length = 290 Score = 150 bits (380), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 92/272 (33%), Positives = 148/272 (54%), Gaps = 4/272 (1%) Query: 11 IAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDL 70 + + VR + ++V++ R L + +G P +YV ++ +A G Sbjct: 8 MGKPVRERILEEVRSVTEKVDRIGKLVSISIGDVPEVAVYVRNQARAASTAGLPFDQEFW 67 Query: 71 PETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGR 130 ++ E +I +N D + GI++Q P+P I+ + IHP KDV+G +P ++G Sbjct: 68 GADVTQDECKAMIQKMNDDPEVLGIILQRPVPDHINVRSLQSAIHPLKDVEGMNPASIGN 127 Query: 131 LCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTH 190 + + PCT V L+ + GL V++G S IVG+P +M L+ G T TV H Sbjct: 128 IVYNDVAMAPCTAAAAVELIRETGLKLEGLEVVMVGHSEIVGKPAAMMLMAEGATVTVCH 187 Query: 191 RFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE----NGKVVGDVVF 246 T+++ H AD+++VAVGK I D +K GA VID+GIN++ N ++VGDV Sbjct: 188 HLTRSVAMHSRRADVIVVAVGKAHLIGADMVKPGAAVIDIGINQITEADGNTRIVGDVDT 247 Query: 247 EDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 + + A ++TPVPGGVGP+TVA L+ N ++A Sbjct: 248 DAVKEIAGWVTPVPGGVGPVTVAILMRNAVRA 279 >UniRef50_A6BAZ7 Fold bifunctional protein (Ppdc) (Fragment) n=1 Tax=Vibrio parahaemolyticus AQ3810 RepID=A6BAZ7_VIBPA Length = 183 Score = 150 bits (378), Expect = 6e-35, Method: Compositional matrix adjust. Identities = 82/110 (74%), Positives = 93/110 (84%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A+ IDG I+Q VRSEVA +V+AR+AAGLRAPGLAVVLVG +PASQ+YV SKR+ACEE Sbjct: 1 MTAQNIDGTLISQTVRSEVAARVKARVAAGLRAPGLAVVLVGEDPASQVYVGSKRRACEE 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKV 110 VGFVS+S+DLP +TSE ELL LID LN DN IDGILVQLPLPAGID V Sbjct: 61 VGFVSKSFDLPASTSEEELLALIDELNNDNEIDGILVQLPLPAGIDTTHV 110 >UniRef50_A5IXS7 FolD bifunctional protein(Methylenetetrahydrofolate Dehydrogenase; Methenyltetrahydrofolate cyclohydrolase) n=1 Tax=Mycoplasma agalactiae PG2 RepID=A5IXS7_MYCAP Length = 286 Score = 149 bits (375), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 102/287 (35%), Positives = 151/287 (52%), Gaps = 14/287 (4%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I++GK IA++ E+ ++ + R P L+++ VG NPAS +Y+ +K K EE+G Sbjct: 3 ILNGKIIAEERTVELKKEFEEITKLIGRQPVLSIIQVGDNPASSLYIKNKIKKAEELGVK 62 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF- 123 + Y E S+ LL+ +D LN ++ DGI+VQLPLP I ++ I +KDVDG Sbjct: 63 ATLYKFDEDISQNSLLKKLDVLNEES--DGIIVQLPLPEHISPKVIMNGIRLEKDVDGLC 120 Query: 124 --HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 +N P T I+ L+ Y ID G A VIG S +VG+P + L Sbjct: 121 EKSTFNFYNDKYDELSFTPATAAAIIDLINYYKIDLNGKKAAVIGRSYLVGKPTAFLLKK 180 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE-NGK- 239 G + ++ T + VE+ADLL+ A G+P + + IK+GA +ID G +E GK Sbjct: 181 LGAMVSTYNKNTG--INGVESADLLVSAAGQPDLVKKENIKDGAWLIDAGTTMIEREGKK 238 Query: 240 -VVGDVVF--EDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 VGD E+ Y TP PGG+GP+TV L +N L ++Y Sbjct: 239 CFVGDASLTPEEYQLLEGY-TPTPGGIGPLTVIWLFKN-LAKAIKYE 283 >UniRef50_B7J0W5 Methenyltetrahydrofolate cyclohydrolase n=22 Tax=Borrelia RepID=FOLD_BORBZ Length = 308 Score = 147 bits (370), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 92/252 (36%), Positives = 140/252 (55%), Gaps = 10/252 (3%) Query: 35 GLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDG 94 L VVL PAS +YV+ K + +E+G + ++++LE+ID N + + DG Sbjct: 39 ALKVVLANDEPASNLYVSIKSRVAKEIGLNVEVIKFSANSVQSDILEVIDRENKNLSTDG 98 Query: 95 ILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPR-LRPCTPRGIVTLLERY 153 I+VQLPL G+D +L I KDVDG N+G++ + PCT ++ +L Sbjct: 99 IIVQLPLLKGMDLNSILNSIVYSKDVDGLSFVNLGKMILGDKKGFIPCTALAVLKILRDE 158 Query: 154 NIDTFGLNAVVIGASNIVGRPMSMELLLAG----CTTTVTHRFTKNLRHHVENADLLIVA 209 I T G VV+G S +VGRP+S +LL+ T H + L ++ AD++I A Sbjct: 159 GIKTLGKTVVVVGRSPLVGRPIS--ILLSSKPYDATVIACHSKSIYLDVYLRQADIVISA 216 Query: 210 VGKPGFIPGDWIKEGAIVIDVGINRLE--NGKVV-GDVVFEDAAKRASYITPVPGGVGPM 266 VGKP I + VID+GI+ +E NGK++ GD F++ + +ITPV GG+GP+ Sbjct: 217 VGKPRLIDKSMLCGKPYVIDIGISEIETDNGKILSGDTDFDNIKECVKFITPVKGGIGPV 276 Query: 267 TVATLIENTLQA 278 TV L+ NT++A Sbjct: 277 TVLMLMFNTIKA 288 >UniRef50_D1B5M7 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B5M7_THEAS Length = 292 Score = 147 bits (370), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 105/276 (38%), Positives = 146/276 (52%), Gaps = 15/276 (5%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 ++ G A V+ V ++V A L LA V V S+ AS+ Y ++ +AC+E G + Sbjct: 3 LMRGSEPASWVKGWVRRQVSA-----LGGCCLASVSVSSHGASEAYRRNQIRACQEAGIL 57 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 R D+ + L+E I LN D +DGI+VQ PLP G D +VL+ + P KD +G H Sbjct: 58 VRPVDVAPSLGILGLIETIRELNGDREVDGIIVQTPLPEGWDLSEVLQAMDPAKDAEGVH 117 Query: 125 PYNVGRL---CQRAPRLRPCTPRGIVTLLERYNI-DTFGLNAVVIGASNIVGRPMSMELL 180 P N+G+L + P PC V LLE Y + D G+ V+G S VGRP+ LL Sbjct: 118 PENLGKLFLGVKGHP--LPCAAWAAVGLLEWYGLWDLSGMVCAVVGHSVNVGRPIGALLL 175 Query: 181 LAGCTTTVTHRFTKN--LRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 T H+ T L V ++ ++I A G PG I ++ GA V+DVG E G Sbjct: 176 QRNGTVLQMHKHTPRDVLEELVSSSQVVISATGVPGLIGPGMVRPGAWVVDVGTTPTERG 235 Query: 239 KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIEN 274 +VGD V A A ++PVPGGVGP+TVA L+ N Sbjct: 236 -LVGD-VDPQCASVAHGLSPVPGGVGPLTVALLMAN 269 >UniRef50_Q4DH06 Methylenetetrahydrofolate dehydrogenase-like protein, putative n=1 Tax=Trypanosoma cruzi RepID=Q4DH06_TRYCR Length = 375 Score = 146 bits (369), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 106/332 (31%), Positives = 161/332 (48%), Gaps = 61/332 (18%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A+I+ G+ ++ + +++Q +A +P LAVV+VG+ S+ YV+ K++ E Sbjct: 1 MKAEILLGRPLS----GTLIERIQHEVARLSCSPSLAVVMVGNRQDSRRYVSVKQRTAEA 56 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 G LPET SE L + + ++ DN DG+L+QLP+P+ + L IHP KDV Sbjct: 57 CGIRFHLLSLPETVSEERLHQELRRISDDNAFDGVLLQLPIPSHLRVRPALLCIHPGKDV 116 Query: 121 DGFHPYNVG----------------------------RLCQRAPRLRPCTPRGIVTLLER 152 DG HP N G RL PCT + LL Sbjct: 117 DGLHPINAGSLFLDGNPIYEEAVHRGSSAEKEEALASRLLNEGRYFVPCTALAVHALLFS 176 Query: 153 YNIDTFG-----------LNAVVIGASNIVGRPMSMEL------LLAGCTTTVTHRFTKN 195 Y + L+AV+I S +VG P + L L+ C+ + K Sbjct: 177 YLANRTAVVPTPSKKPKNLHAVIINKSMVVGVPTAALLQKEDNFLVTLCSRSNDLEAVKE 236 Query: 196 LRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINR-------LENG--KVVGDVVF 246 + AD+L+ A+G P + D++K GAIV+DV IN + +G +V GDV Sbjct: 237 VS---RQADVLVTALGIPRVVTADFVKPGAIVLDVAINEDCASGGEMTSGSRRVCGDVDL 293 Query: 247 EDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 ++A+ +TPVPGG+GP+TVA L++NTL+A Sbjct: 294 ASVREKAAAVTPVPGGIGPLTVAYLMQNTLKA 325 >UniRef50_A1RQQ5 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=Thermoproteaceae RepID=FOLD_PYRIL Length = 311 Score = 146 bits (368), Expect = 9e-34, Method: Compositional matrix adjust. Identities = 98/263 (37%), Positives = 140/263 (53%), Gaps = 19/263 (7%) Query: 33 APGLAVVLVGSNP----ASQIYVASKRKACEEVGFVSRSYDL---PETTSEAELLELIDT 85 P LAV+L+ +P YV+ K + + +G ++L P E L+LI+ Sbjct: 31 TPKLAVLLLNDDPIELETQHKYVSLKARDIKSIGGEVELFELYKEPPEKREVAALKLIER 90 Query: 86 LNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLR---PCT 142 LN + + GILVQ PLP +D K+ ER+ P KDVDG P N RL R PCT Sbjct: 91 LNNADDVTGILVQKPLPPYVDETKIFERLSPLKDVDGLTPENKKRLVTGFDLDRDILPCT 150 Query: 143 PRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVEN 202 P GI+ L +Y ID G + VV+G +VG P+S+ L+ T TV H +K+ +++V N Sbjct: 151 PAGILELFRQYKIDVRGKDVVVVGKGTLVGFPLSIMLMQLDATVTVLHALSKDRKYYVRN 210 Query: 203 ADLLIVAVGK--------PGFIPGDWIKE-GAIVIDVGINRLENGKVVGDVVFEDAAKRA 253 AD++I AVG+ P + GD+IKE +V G K DV + A++A Sbjct: 211 ADIIISAVGRPPELYSDNPWKLTGDFIKEGAVVVGVGGKVDPVTKKWYFDVDEKSVAEKA 270 Query: 254 SYITPVPGGVGPMTVATLIENTL 276 SY+TP GGVG T A L++N + Sbjct: 271 SYLTPNIGGVGLATRARLVKNLI 293 >UniRef50_Q4A6B1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Mycoplasma synoviae 53 RepID=FOLD_MYCS5 Length = 278 Score = 141 bits (355), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 94/282 (33%), Positives = 151/282 (53%), Gaps = 16/282 (5%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAP-GLAVVLVGSNPASQIYVASKRKACEEVG 62 KI+ G+ A+Q ++ +++ L P LA++ VG S YV K K +E+G Sbjct: 2 KILSGREKAEQDLKQLKKELDE---LNLNRPIKLAIIQVGDKMESNRYVEQKLKKAKEIG 58 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 ++ + E ++ LL +D +N + DGIL+QLPLP + +L+ + +KD+DG Sbjct: 59 IEAKCFKFDENITQKRLLLAMDEINEN--WDGILIQLPLPKHLPKEVILDAVPYEKDIDG 116 Query: 123 FHPYNVGRLCQRAPR----LRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSME 178 N L P R ++ L+E + I+ V+G S++VG+P++ Sbjct: 117 LSHRNEFILYNEKNSDDKFFVPAAARAVLELIEHHEINYKKKKVAVVGRSHLVGKPVAHI 176 Query: 179 LLLAGCTTTVTHRFTKNLR-HHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 L G + + F +N V +AD++IVA+G P +I + IK+GAI+IDVG N +N Sbjct: 177 LKRRGASVST---FDENTPIKLVASADIVIVAIGVPKYIKAENIKQGAIIIDVGTNYDQN 233 Query: 238 --GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 + GDV E +AS ITPVPGGVGP+TV L++N ++ Sbjct: 234 DPSVIFGDVDHESVKTKASAITPVPGGVGPLTVVCLLKNLVE 275 >UniRef50_D1VRZ1 Bifunctional protein FolD n=1 Tax=Peptoniphilus lacrimalis 315-B RepID=D1VRZ1_9FIRM Length = 284 Score = 138 bits (347), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 81/254 (31%), Positives = 129/254 (50%), Gaps = 2/254 (0%) Query: 12 AQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLP 71 ++ +R + +K+ +I P LA++ +G P Y K +E+ Y L Sbjct: 18 SKDLRKRLKEKLLEKIENLNEKPVLAIIRLGQRPEDLSYEKGLTKTAKELSIPVDIYKLE 77 Query: 72 ETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRL 131 T +L+ LI+ LN D + GIL+ PLP ID +V I P KD+D +P N ++ Sbjct: 78 VQTKTIQLISLIEKLNEDKKVKGILIFRPLPKHIDEKEVALAISPQKDLDCINPINKAKI 137 Query: 132 CQ-RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTH 190 P +P+ V L+E Y + A++I S +VG+P++M LL T T+ H Sbjct: 138 YDGDVNGFIPLSPKAAVMLMEDYGYN-LAKRALIINRSQVVGKPLAMLLLNRNATVTIAH 196 Query: 191 RFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAA 250 T+N++ ++ +D + A+GK + + E +I+ID+ I ENGK+ GD+ ED Sbjct: 197 SKTENIKELIKKSDYVFTAMGKMKSLDRSFFTEKSIIIDLSIGIDENGKLCGDIDQEDVN 256 Query: 251 KRASYITPVPGGVG 264 TPVPGGVG Sbjct: 257 DFVQAYTPVPGGVG 270 >UniRef50_B8ZZU9 Putative uncharacterized protein MTHFD2 n=2 Tax=Homininae RepID=B8ZZU9_HUMAN Length = 267 Score = 137 bits (345), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 94/287 (32%), Positives = 131/287 (45%), Gaps = 88/287 (30%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A +I G+ +AQQ++ EV Q+V+ +A+G + P L+V+LVG NPAS YV +K +A V Sbjct: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVE 96 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 ID ++ + PDKDVDG Sbjct: 97 H-----------------------------------------IDERRICNAVSPDKDVDG 115 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 FH NVGR+C + P TP G+ +++R I T G N VV G S VG P++M L Sbjct: 116 FHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 175 Query: 183 GC--------TTTVTHRFT--KNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGI 232 G T T++HR+T + L+ H AD++I A G Sbjct: 176 GAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAG--------------------- 214 Query: 233 NRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 ++A YITPVPGGVGPMTVA L++NT+ A Sbjct: 215 ----------------VRQKAGYITPVPGGVGPMTVAMLMKNTIIAA 245 >UniRef50_Q1J118 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=Deinococcus RepID=FOLD1_DEIGD Length = 288 Score = 136 bits (342), Expect = 9e-31, Method: Compositional matrix adjust. Identities = 93/248 (37%), Positives = 134/248 (54%), Gaps = 7/248 (2%) Query: 34 PGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTID 93 P L VL + AS++YV SK + E +G + DL + EL ++ L+AD + Sbjct: 35 PHLVSVLASEDEASRVYVHSKARQAERLGVRFTARDLGADAKQDELHAVLQALSADADVH 94 Query: 94 GILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLC--QRAPRLRPCTPRGIVTLL- 150 G++++LPL G+D L I P KDV+G P N+ + + A L P TPR + LL Sbjct: 95 GVVLELPLAPGLDADAALRHIAPCKDVEGLTPANLALIAAGREAEALLPPTPRSVRFLLR 154 Query: 151 ERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAV 210 E D G VIG VGRP++ L G T T+ + T++LR + D ++VAV Sbjct: 155 EVLGDDLRGRRVAVIGPGRTVGRPLTFMLNNRGVTVTLCNECTRDLRDVLAPQDAVVVAV 214 Query: 211 GKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVAT 270 G G + + ++ +VID GIN + G VVGD V D RA TPVPGGVGP+T A Sbjct: 215 GHAGLLRPEQVQPHHVVIDAGIN-VTPGGVVGDAV-PDLPVRAQ--TPVPGGVGPLTSAL 270 Query: 271 LIENTLQA 278 + +N ++A Sbjct: 271 MYQNLVRA 278 >UniRef50_P47259 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Mycoplasma RepID=FOLD_MYCGE Length = 273 Score = 134 bits (337), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 77/239 (32%), Positives = 125/239 (52%), Gaps = 7/239 (2%) Query: 36 LAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGI 95 L ++ + +S ++ K AC VG S L ++AEL+E I +LN D + GI Sbjct: 26 LVIIQANDDDSSDSFIKQKLIACNTVGAKSELIKLSNQITQAELIEKIISLNHDVNVTGI 85 Query: 96 LVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNI 155 ++QLP+ +D +LE I+P KDVDG ++ + +PC I+TL E +N+ Sbjct: 86 ILQLPVYPHLDKNSLLEAINPLKDVDGLTTNHLAEI-------KPCIVEAIITLKELFNL 138 Query: 156 DTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGF 215 + VV+G G+P+ L +G + T N +++AD++ A+GK F Sbjct: 139 EFNNQKIVVVGLGITGGKPIYEFLKTSGYKVQACDKDTPNTFELIKSADIVFTAIGKSHF 198 Query: 216 IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIEN 274 K+G I+ D+G++R + K+ GD+ E K+A + T PGGVGP TV +I+N Sbjct: 199 FQAKNFKKGVILFDIGVSRNKQNKLCGDINPEGIEKKARWWTKTPGGVGPFTVLAIIKN 257 >UniRef50_A8IQS8 Methylenetetrahydrofolate dehydrogenase/ methylenetetrahydrofolate cyclohydrolase n=1 Tax=Chlamydomonas reinhardtii RepID=A8IQS8_CHLRE Length = 351 Score = 130 bits (327), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 88/249 (35%), Positives = 113/249 (45%), Gaps = 53/249 (21%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M +IDGK +A ++R E A K ++ + R PGLAVV+VG SQ YV K+K CE Sbjct: 25 MNGNVIDGKAVAAKIREETAAKSRSLKPSMARVPGLAVVIVGERKDSQTYVRMKKKVCEA 84 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 V L I +KDV Sbjct: 85 V-------------------------------------------------LGAISVEKDV 95 Query: 121 DGFHPYNVGRLCQ--RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSME 178 DGFHP N+GRL R P PCTP G + LLER I G AVV+G SNIVG P ++ Sbjct: 96 DGFHPLNIGRLAMKGREPLFTPCTPLGCMVLLERCGIPIKGKRAVVVGRSNIVGMPAALL 155 Query: 179 LLLAGCTTTVTHRFT--KNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE 236 L TV H T + AD++I A G+ + G W+K GA VIDVG N ++ Sbjct: 156 LNKRDAAVTVVHSATPKADAEAMCRQADIIIAAAGQAQLVRGSWVKPGAAVIDVGTNPID 215 Query: 237 NGKVVGDVV 245 + G V+ Sbjct: 216 DKTKAGAVI 224 >UniRef50_C5CI88 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=FOLD_KOSOT Length = 277 Score = 130 bits (326), Expect = 7e-29, Method: Compositional matrix adjust. Identities = 89/276 (32%), Positives = 146/276 (52%), Gaps = 16/276 (5%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNP--ASQIYVASKRKACEEVG 62 ++DGK +A+ + +E+ + + L+ +VL S P +++ Y+ S K ++G Sbjct: 4 LLDGKPVAKMIYAEIKEWL-----GNLQEKPPKLVLFCSEPDDSTKTYMNSIVKRGGKLG 58 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 E +E I LN + G+++ PL +D V+ + +KDV+G Sbjct: 59 ISVEICHAGENP-----VEEIKKLNESRDVAGVMIMHPL-KNVDEKLVVSALSLEKDVEG 112 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 P N+G + P T ++ +L Y++ G + ++G S VG+P+SM +L Sbjct: 113 RTPGNLGGIMTGDESFAPPTAEAVMEILRFYDVSLSGKDVTIVGRSTTVGKPLSMLMLKK 172 Query: 183 GCTTTVT--HRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 G TVT H TKNL ++ A++L+ AVG+ GFI + + + +I+IDVGIN L +GK+ Sbjct: 173 GIDATVTICHSRTKNLVEKIKRANVLVSAVGRAGFITKEMVGKDSIIIDVGIN-LYDGKI 231 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 VGDV FE + ITPVPGGVG +T A L + + Sbjct: 232 VGDVDFEQVEPEVAAITPVPGGVGIVTTAILFRHFM 267 >UniRef50_C8WN84 Tetrahydrofolate dehydrogenase/cyclohydrolase n=1 Tax=Eggerthella lenta DSM 2243 RepID=C8WN84_EGGLE Length = 289 Score = 129 bits (324), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 91/278 (32%), Positives = 142/278 (51%), Gaps = 8/278 (2%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRA---PGLAVVLVGSNPASQIYVASKRKACE 59 A+++ GK + + A ++ARI A RA P LA+V VG P Y + RK E Sbjct: 2 AELLKGKPVVDSM----ALDLRARIEALGRAKVVPALALVRVGQRPDDLSYERTARKRAE 57 Query: 60 EVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKD 119 +G R Y+L E +A + I +N D + G L+ PLP+ +D + E + P KD Sbjct: 58 SLGIAIRPYELDEFAPQAAIEAAIHEVNRDENVHGCLLFRPLPSFVDESHMCELLDPKKD 117 Query: 120 VDGFHPYNVGRLCQRA-PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSME 178 +DG ++ + P T + LL+ Y + G + VV+G S +VG+P+SM Sbjct: 118 IDGITLASLASVFTDGHAGYPPATAAACIQLLDHYQVPLQGKHVVVVGRSLVVGKPVSMM 177 Query: 179 LLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 LL + T+ H T+NL + +AD++I A G+ + G V+DVGIN G Sbjct: 178 LLRRNASVTICHSKTENLADIMRSADVVICATGRARTFGAQFFGPGQTVLDVGINFDTQG 237 Query: 239 KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 + GDV F + + ITPVPGG+G +T + + +T+ Sbjct: 238 NLCGDVDFAEVEPVVAAITPVPGGIGTVTTSVTMAHTV 275 >UniRef50_Q0AZF5 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Syntrophomonas wolfei subsp. wolfei str. Goettingen RepID=FOLD1_SYNWW Length = 277 Score = 128 bits (322), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 99/280 (35%), Positives = 148/280 (52%), Gaps = 14/280 (5%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +II G IAQ++R ++ +K + G+ +P LA++LVG YV K KA G Sbjct: 2 EIISGSQIAQEIRQKLKEKNERE---GI-SPCLAMILVGGQKEDLHYVGLKEKAATATGG 57 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNV--KVLERIHPDKDVD 121 SR LPE TS+ EL+ I LN D +DGIL+QLPLPA ++ ++L I PDKDVD Sbjct: 58 KSRLLHLPEDTSQQELMAKIAELNQDEQVDGILLQLPLPAALEEQTDEILAAIRPDKDVD 117 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GF N GR+ P C + ++ER+ G AV++G S + P++ ++ Sbjct: 118 GFSLVNRGRMSGDRPGFISCAALACLEVIERFFPSLAGKKAVLVGDSFDLIIPLATIMIK 177 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 C +V + L AD+L+V G+ G + + + G ++ID G G V Sbjct: 178 RACQLSVLPSYEPGL---ASGADILVVEKGRAGIVQAEGLAPGVLIIDAGFY-WGAGGVC 233 Query: 242 GDVVFEDAAKRASY---ITPVPGGVGPMTVATLIENTLQA 278 G+ V A +R + + PVPGG+GP+ +A L+EN QA Sbjct: 234 GN-VDRAALERQGFEARLLPVPGGMGPILIAKLMENLAQA 272 >UniRef50_A9BIV9 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=Thermotogaceae RepID=FOLD_PETMO Length = 273 Score = 127 bits (320), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 85/248 (34%), Positives = 137/248 (55%), Gaps = 12/248 (4%) Query: 34 PGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTID 93 P L ++V + +++ Y+ S+++ ++ G + ++ E+ +L + N D+ D Sbjct: 27 PKLVSLVVEPDESTKSYLNSQKRNAKKFGI---NLEIVESN---DLTNDLRKYNEDDDTD 80 Query: 94 GILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERY 153 I + PL G + + + I+P+KDV+G +N+G + PCT +V ++E Sbjct: 81 AIFIARPLKKGYTELDIAKYINPEKDVEGVSLHNIGSMFYEKELFVPCTAEAVVKIIED- 139 Query: 154 NIDTFGLNAVVIGASNIVGRPMSMELLLAG--CTTTVTHRFTKNLRHHVENADLLIVAVG 211 D G N V++G S VG+P ++ L G T TVTH TKNL+ + AD+L+ A+G Sbjct: 140 TTDVRGKNIVILGRSTTVGKPAAIMLQRHGRDATVTVTHTKTKNLKEITKEADILVAAIG 199 Query: 212 KPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATL 271 K F+ ++KEG IVIDVGIN ++ GK+VGDV +TPVPGGVG +T A L Sbjct: 200 KANFVDSTFVKEGMIVIDVGINVVD-GKIVGDV--NKDVSEICQLTPVPGGVGSVTTAIL 256 Query: 272 IENTLQAC 279 + N +A Sbjct: 257 MRNVFRAA 264 >UniRef50_B9CK25 Bifunctional protein FolD n=1 Tax=Atopobium rimae ATCC 49626 RepID=B9CK25_9ACTN Length = 285 Score = 127 bits (318), Expect = 6e-28, Method: Compositional matrix adjust. Identities = 81/247 (32%), Positives = 124/247 (50%), Gaps = 2/247 (0%) Query: 34 PGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTID 93 P LA++ +G Y + K E++G R L S+ ++ E I +++D I Sbjct: 32 PTLAILRLGERSDDLAYERAALKRAEKIGIAVRQTVLSRNASQHDVDETIRDISSDPHIH 91 Query: 94 GILVQLPLPAGIDNVKVLERIHPDKDVDGF-HPYNVGRLCQRAPRLRPCTPRGIVTLLER 152 L P P I+ + P KDVD + L R+ L PCT ++ +L+ Sbjct: 92 ACLPLRPFPKTINEAGAFALLSPSKDVDCVTDSMLLATLSGRSCALAPCTAEAVIAILDH 151 Query: 153 YNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGK 212 Y I+ G A V+G SN++GRP++ L + T T+ H T +L A++L+VA G+ Sbjct: 152 YGIEIAGARAAVVGRSNVIGRPVAALLTMRDATVTLCHSRTVDLPSVTCEAEILVVAAGR 211 Query: 213 PGFIPGDWIKEGAIVIDVGINRLE-NGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATL 271 I ++ G VIDVGIN E + K+VGDV E + TPVPGGVG +T A L Sbjct: 212 ARMIDSGYVAPGQTVIDVGINWDEASQKLVGDVDAEAIKDTVAAYTPVPGGVGSVTTAIL 271 Query: 272 IENTLQA 278 ++ ++A Sbjct: 272 AKHVIEA 278 >UniRef50_UPI00016B2244 FolD bifunctional protein n=2 Tax=candidate division TM7 RepID=UPI00016B2244 Length = 338 Score = 122 bits (306), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 88/278 (31%), Positives = 136/278 (48%), Gaps = 17/278 (6%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGS-NPASQIYVASKRKACEEVG 62 KI++G +A V+ ++V+ + P L+VV V S N Y+ K+ ++ Sbjct: 67 KILNGAELASFVKVRQLKQVRNLRQSKKIIPKLSVVYVDSGNKVIDTYINLKKAYANDIL 126 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 Y T ++E ++ L+ D++I GI+VQLPLP +D ++L I+P+KDVDG Sbjct: 127 VEFSVYKENADT----IIERLNILSRDDSIHGIIVQLPLPGDLDTDQILSHINPNKDVDG 182 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 N P TP I LL Y ID G N ++G +VG P++ + Sbjct: 183 LSGGN----------FTPATPMAINWLLSGYGIDLSGKNVAIVGRGKLVGAPLTRLWKES 232 Query: 183 GCTTTVTHRFT-KNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 G V + +L + D+++ A G G I +K GA+VID G E G + Sbjct: 233 GYNVDVFEKGDGYDLHIEIPKYDVIVTATGATGLIKSSMLKSGAVVIDAGTAS-EKGIIK 291 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 GD+ + ++ ITP GGVGP+TVA L +NT+ A Sbjct: 292 GDLSDDVRERKDLIITPDKGGVGPLTVAALFDNTILAA 329 >UniRef50_Q98QV3 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Mycoplasma pulmonis RepID=FOLD_MYCPU Length = 272 Score = 122 bits (305), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 85/281 (30%), Positives = 144/281 (51%), Gaps = 11/281 (3%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M K++ + + Q R+E+ +K +++ ++ A+VL+G N +S+IYV K + ++ Sbjct: 1 MMKKLLSNELV-QIKRAELKEKF-SKLDQKVK---FAIVLIGDNASSKIYVKKKIEFAQD 55 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G ++ + E L + + D DGI++QLP+ D ++L I +KD+ Sbjct: 56 IGVEAKLFHFEENVDFNLLKDAFKKI--DKEYDGIILQLPV-LHFDVNELLLMIDKNKDL 112 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG +P N + + P T R I T L+ + I V+G S +VG+P+S L Sbjct: 113 DGLNPENEKAFYENRECIIPATARAIWTFLKFHKISVENKKVFVVGQSRLVGKPISQFLK 172 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 V + T E AD+LIVA G I + IKE +I+IDVG +++ N K+ Sbjct: 173 NNNAIVRVFDKSTG--LKGTEEADILIVATGVAQLIKAENIKENSILIDVGFSKI-NNKI 229 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 GD+ E ++A TP G +GP+TV +L EN + ++ Sbjct: 230 YGDLDIESIKEKALKYTPPIGAIGPVTVLSLFENLYEIILK 270 >UniRef50_Q7NAE4 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Mycoplasma gallisepticum RepID=FOLD_MYCGA Length = 283 Score = 116 bits (290), Expect = 9e-25, Method: Compositional matrix adjust. Identities = 78/280 (27%), Positives = 144/280 (51%), Gaps = 20/280 (7%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNP--ASQIYVASKRKACEEVGF 63 +DG ++Q+++ ++A+KV + + ++++ S+P AS+IYV +K C+ +G Sbjct: 5 LDGTKLSQKLKEDLAKKVNNQ--------KIKILIIISDPSEASRIYVRNKINYCDSLGI 56 Query: 64 VSRSYDLPETTSEAELL-ELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 + YDL + + + E+ ++ N +G+LVQLP+ +D K++E I DVD Sbjct: 57 QTEVYDLSKIDDTNQFIVEMNQKISLSNP-NGVLVQLPIKERLDTNKIIENIPIRLDVDA 115 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 F + + + ++ PC ++ L + Y + ++IG +P+ L Sbjct: 116 FLYHRFDQ--DQKEKVIPCVLNAVLELFKEYQLSFLDKKILLIGNGITSNQPIVNYLNEH 173 Query: 183 GCT-TTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL---ENG 238 +T ++ L + ADL+I AVGK F+ K G I ID+GI++ E Sbjct: 174 QIKFDLITKENSQLLEEKTKVADLVISAVGKAKFLANYQFKRGVIFIDIGIDKYFDPEQS 233 Query: 239 K--VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 K + GD ++ + ASY TP PGG+GP+T+ +L++N + Sbjct: 234 KYLICGDFDYDKLKEIASYGTPTPGGIGPLTIYSLVKNLI 273 >UniRef50_Q9XYB0 PugilistDominant (Fragment) n=2 Tax=Eukaryota RepID=Q9XYB0_DROME Length = 268 Score = 115 bits (287), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 70/178 (39%), Positives = 100/178 (56%), Gaps = 6/178 (3%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLR--APGLAVVLVGSNPASQIYVASKRKACE 59 AKII G +A+ +R E+ +V A ++ L PGL +V VG S +Y+ K KA Sbjct: 3 GAKIISGTAVAKSIREELRNEVTA-MSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAAT 61 Query: 60 EVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAG--IDNVKVLERIHPD 117 E+G + LP + +E ELL+ I+ LN D + GI+VQ+PL ID+ ++ + + P+ Sbjct: 62 EIGIDAAHVQLPRSITEVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPE 121 Query: 118 KDVDGFHPYNVGRLC-QRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRP 174 KDVDG H N GRL PCTP G + L+ R ++ G AVV+G S IVG P Sbjct: 122 KDVDGLHTVNEGRLAIGDLGGFLPCTPWGCLELIRRSGVEIAGARAVVLGRSKIVGTP 179 >UniRef50_UPI0001B58450 methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase n=1 Tax=Streptomyces sp. SPB78 RepID=UPI0001B58450 Length = 357 Score = 109 bits (273), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 72/212 (33%), Positives = 107/212 (50%), Gaps = 1/212 (0%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A+ + GK +A +R V+A AG P LAVV + +S YV S A E+ G Sbjct: 12 ARPLRGKALAASLREGTRAAVEATRKAG-STPKLAVVTATDDESSAWYVRSLVSAAEKSG 70 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 + L S E+ + + L D ++ G+++Q PLP G+D + E + KDVDG Sbjct: 71 LLHEVVHLGPKASTEEVRDALRGLGEDGSVHGVILQTPLPPGVDARALAEAVPAAKDVDG 130 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 +P ++GRL P T ++ LL+ Y + G AVV+G S +VG+P++ LL Sbjct: 131 ANPLSLGRLAAGLAAFAPATAEAVIALLDHYEVPLRGARAVVVGRSTVVGKPLAHLLLAR 190 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPG 214 T TV H T++L AD+LI A G G Sbjct: 191 DATVTVCHSRTRDLAEVTREADILIAARGAAG 222 >UniRef50_C7GZF5 FolD protein n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7GZF5_9FIRM Length = 293 Score = 108 bits (271), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 86/287 (29%), Positives = 137/287 (47%), Gaps = 26/287 (9%) Query: 13 QQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPE 72 +Q+ E+ +++ +A +A+V N A +Y + K E++ RS L E Sbjct: 6 KQISEELLGEIKNDVAHLGFNKEIAIVKSAKNSAGTVYENAIIKKAEKLNIPVRSAVLEE 65 Query: 73 TTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNV-GRL 131 + + + L+ D I GI+ PL ID +V E I +KD+DG ++ G Sbjct: 66 GVDTEKAFKTVAKLSEDKDIAGIIPMQPLDESIDISRVKEAIACNKDIDGQTEKSMSGVF 125 Query: 132 CQRAPRLRPCTPRGIVTL----LERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTT 187 R L P T + + L R N T L ++G S +VGRP+SM + T T Sbjct: 126 SFRKDALAPATALACIEIAKKVLGRENFKT--LKVCILGRSLVVGRPLSMLFMKDDATVT 183 Query: 188 VTHRFT--KNLRHHVENADLLIVAVGKPGFIPGDWIKEGA---------------IVIDV 230 V H T N+ + +AD+++ AVG P F+ + + EG+ + IDV Sbjct: 184 VCHSKTGYDNIISSMADADIIVSAVGIPYFVTKEMV-EGSFERRKELKSIDEDDRLFIDV 242 Query: 231 GINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 GIN ++GK+ GD+ E +Y+TPVP GVG +T + L +N L+ Sbjct: 243 GIN-FKDGKITGDMESEAFKDEVAYVTPVPSGVGLVTTSVLFKNLLK 288 >UniRef50_C7HUG7 Bifunctional protein FolD protein n=1 Tax=Anaerococcus vaginalis ATCC 51170 RepID=C7HUG7_9FIRM Length = 263 Score = 107 bits (266), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 65/251 (25%), Positives = 120/251 (47%), Gaps = 5/251 (1%) Query: 17 SEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSE 76 +E+ + I + L ++ ++ A Y + + C E Y E + E Sbjct: 7 NEIKNDILKNIKYCNKKKSLLIISQNNDLAVNQYKNAIIRRCNEFNI---DYIDKEFSKE 63 Query: 77 AELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAP 136 L++I+ N IDG +V PL D + E I P D+DGF ++G++ + Sbjct: 64 DNHLDIINYCNNLKNIDGFIVLQPLLESTDLDYLRENI-PFNDLDGFKYDSLGKIMSKKF 122 Query: 137 RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNL 196 P T + I+ + N+D G + ++ ++NI+G+P++M L + T+ + TKN Sbjct: 123 ENLPQTVKSIIKFINYMNLDLEGKDIIIANSTNIIGKPLAMYLNYKKASVTLFNSKTKNQ 182 Query: 197 RHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYI 256 + ++N D+ I A+GK + D+ + G I+ID G++ ++ G + GD+ +E I Sbjct: 183 KEKIKNCDIFISAIGKANYYNKDYFRNGQIIIDAGVSFVD-GNMYGDIDYEYIKDLDIKI 241 Query: 257 TPVPGGVGPMT 267 GVG +T Sbjct: 242 VTCKNGVGSIT 252 >UniRef50_B0RZW6 Methylenetetrahydrofolate dehydrogenase n=2 Tax=Finegoldia magna RepID=B0RZW6_FINM2 Length = 267 Score = 100 bits (248), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 67/233 (28%), Positives = 118/233 (50%), Gaps = 6/233 (2%) Query: 13 QQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPE 72 +++R ++ +++ + R +A V VG N Y + + C ++ L E Sbjct: 7 KELREDLGKRIIDGVEKLGREVKVATVRVGENAGDISYEKAVKNNCAKLNITCDQIVLEE 66 Query: 73 TTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGR-L 131 +E +L++ I LN T DGIL+ PL ++ I P+KD+D N+G+ L Sbjct: 67 GENE-KLIQTIKELNE--THDGILMFRPLKDKNLEKEIQYIIAPEKDIDAMGMVNLGKVL 123 Query: 132 CQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHR 191 P T R +V +++ YN D N V++ S ++G+P+ L+ T T+ H Sbjct: 124 AAEEDAYYPATARAVVEIVKYYNFDV--KNVVIVNRSLVLGKPLFNMLIKENKTVTMCHS 181 Query: 192 FTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T++++ +NADL++ AVGK + + + V+DVG++ ENGK+ GDV Sbjct: 182 RTEDIKSFTKNADLVVTAVGKAKMFDDSYFTKDSYVVDVGVSLDENGKLSGDV 234 >UniRef50_B6WAQ3 Putative uncharacterized protein n=1 Tax=Anaerococcus hydrogenalis DSM 7454 RepID=B6WAQ3_9FIRM Length = 164 Score = 96.7 bits (239), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 47/159 (29%), Positives = 89/159 (55%), Gaps = 1/159 (0%) Query: 118 KDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSM 177 +D+DGF ++G++ + + P T R I+ ++ +ID G + ++ ++N++G+P+SM Sbjct: 4 EDLDGFRYDSLGKIMDKNFKNLPQTARSIIKFIDYMDIDLKGKDVIIANSTNVIGKPLSM 63 Query: 178 ELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 L T T+ + T N + ++ AD+ I A+GK F D+ ++G ++ID G + ++ Sbjct: 64 YLNYKKATVTLFNSKTINQKEKIKRADIFISAIGKANFYNVDYFRDGQVLIDAGTSFID- 122 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 GK+ GD+ ++ I GVG +T +LIE L Sbjct: 123 GKMYGDIDYDSLENLKVDIVTCKNGVGSITTLSLIETLL 161 >UniRef50_C7RD94 Tetrahydrofolate dehydrogenase/cyclohydrolase n=3 Tax=Anaerococcus RepID=C7RD94_ANAPD Length = 260 Score = 95.1 bits (235), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 66/241 (27%), Positives = 118/241 (48%), Gaps = 12/241 (4%) Query: 38 VVLVGSNPASQI--YVASKRKACEE--VGFVSRSYDLPETTSEAELLELIDTLNADNTID 93 ++L+ NP S++ Y S K CEE + +V +D S E+L I+T + + D Sbjct: 26 LLLLSKNPTSEVLYYKKSIIKRCEEFDIEYVDCEFD---KESPEEILAFINTFDKE---D 79 Query: 94 GILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERY 153 G ++ P G D + + I +D+D F G + + P T R IV LE Sbjct: 80 GYIILAPFGEGKDLTFLKDNIEI-RDLDAFTYKAQGHTMEGSTERLPQTARAIVRFLEDK 138 Query: 154 NIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKP 213 G + V+ + +G+P++M L+ T T+ R T + ++ ++N+D+ I A+G+ Sbjct: 139 YSSLKGKHIVISNKTTTIGKPLAMNLVTKYATVTMITRHTADQKNIIKNSDIFISAIGRA 198 Query: 214 GFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIE 273 F + ++G +V+DVG L+ GK+VGD+ + + G+G +T L+E Sbjct: 199 NFYDRSYFRDGMLVVDVGTTYLD-GKIVGDIDYGSLEDVDIEVLTNKRGIGALTTLMLLE 257 Query: 274 N 274 + Sbjct: 258 S 258 >UniRef50_B5GAQ6 Tetrahydrofolate dehydrogenase/cyclohydrolase n=1 Tax=Streptomyces sp. SPB74 RepID=B5GAQ6_9ACTO Length = 333 Score = 90.5 bits (223), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 77/237 (32%), Positives = 113/237 (47%), Gaps = 24/237 (10%) Query: 46 ASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGI 105 AS++ K KA +GF LP T S AE + ID NAD+ I I+VQ P PA + Sbjct: 55 ASRVSANQKVKAFSYLGFTVDHLVLPGTVSAAEFADRIDAFNADDHIRAIIVQFPPPARL 114 Query: 106 DNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGI----VTLLERYNIDTFGLN 161 +++R+ KD+DG L R+P T GI + + E +I Sbjct: 115 --TPLVQRLEQIKDIDGL-------LEDRSPHRACATADGISRVVIPVAEEASI------ 159 Query: 162 AVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWI 221 V+GA VGR + + LL + +LR +AD+++ GKP + D I Sbjct: 160 -AVVGARGFVGRGV-VRLLKDHGLDVIPLDIGDDLR-RAAHADIVVSTAGKPHILTPDHI 216 Query: 222 K-EGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 K +V+D G L +G V GD + A ITPVPGGVGP+ +A L++ ++ Sbjct: 217 KPHHRLVVDSGFTPLPDGTVAGD-IHPAATYIPQNITPVPGGVGPIEMAVLMDRIIR 272 >UniRef50_Q02046 Methylenetetrahydrofolate dehydrogenase [NAD+] n=46 Tax=Ascomycota RepID=MTD1_YEAST Length = 320 Score = 90.1 bits (222), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 82/319 (25%), Positives = 139/319 (43%), Gaps = 60/319 (18%) Query: 4 KIIDGKTIAQQVRSEVAQKVQA-RIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 + I +A+ +E+ V+ + + P L L ++PA+++Y +K E +G Sbjct: 6 RTILASKVAETFNTEIINNVEEYKKTHNGQGPLLVGFLANNDPAAKMYATWTQKTSESMG 65 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 F YDL + L E I N D++++GI+V P+ + + + + +KDV+G Sbjct: 66 F---RYDLRVIEDKDFLEEAIIQANGDDSVNGIMVYFPVFGNAQDQYLQQVVCKEKDVEG 122 Query: 123 FHP------YNVGRLCQRAPRLR---PCTPRGIVTLLERYNIDT---------FGLNAVV 164 + Y+ R + RL+ PCTP IV +LE I +G +V Sbjct: 123 LNHVYYQNLYHNVRYLDKENRLKSILPCTPLAIVKILEFLKIYNNLLPEGNRLYGKKCIV 182 Query: 165 IGASNIVGRPMSMELLLAGCTTTVT-----HRFTKNL-----RHHVE------------- 201 I S IVGRP++ L G T +FT+ +HHVE Sbjct: 183 INRSEIVGRPLAALLANDGATVYSVDVNNIQKFTRGESLKLNKHHVEDLGEYSEDLLKKC 242 Query: 202 --NADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITP 258 ++D++I V + P ++IKEGA+ I+ + +D ++AS P Sbjct: 243 SLDSDVVITGVPSENYKFPTEYIKEGAVCINFACTK---------NFSDDVKEKASLYVP 293 Query: 259 VPGGVGPMTVATLIENTLQ 277 + G V T+A L+ N L+ Sbjct: 294 MTGKV---TIAMLLRNMLR 309 >UniRef50_B3QMF3 Tetrahydrofolate dehydrogenase/cyclohydrolase n=2 Tax=Chlorobaculum RepID=B3QMF3_CHLP8 Length = 296 Score = 88.6 bits (218), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 77/278 (27%), Positives = 123/278 (44%), Gaps = 50/278 (17%) Query: 39 VLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQ 98 +L +PAS Y R CE+VG S+DL +T+ E+ + ++++ NAD+ + GI V Sbjct: 33 ILASDDPASATYADYTRAGCEDVGI---SFDLRKTSPES-VRNMLESANADSDVHGIFVY 88 Query: 99 LPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRL---------CQRAPRLRPCTPRGIVTL 149 P+ + ++ + I P KDV+G P+ + +L ++ + PCTP I+ L Sbjct: 89 YPIWGDSRDAELRDLISPHKDVEGLCPHWISKLYANERFDDEARKFKAILPCTPLAILKL 148 Query: 150 LER------YNIDTFGLNAVVIGASNIVGRPMSMEL-----------LLAGCTTTVT--- 189 LE Y + G + S +VGRP++ L + G V Sbjct: 149 LEETEAYIPYGLPFGGQQITIFNRSEVVGRPLAYMLSNDGARVYSFDIDGGFVVDVNDPG 208 Query: 190 -HRFTKNLRHHVENADLLIVAVGKPGF--IPGDWIKEGAIVIDVGINRLENGKVVGDVVF 246 R + +D++I V F I D +K GA+ ++ + ++N F Sbjct: 209 HERVPVTREEALRQSDIVITGVPSKVFDKIKADELKSGAVCLN--FSSIQN--------F 258 Query: 247 E-DAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 E DA + A P VGPMTVA + N LQ YH Sbjct: 259 EPDAKESAGLYIP---RVGPMTVAMCMRNALQLYRNYH 293 >UniRef50_C0Z3J6 AT2G38660 protein n=2 Tax=Arabidopsis thaliana RepID=C0Z3J6_ARATH Length = 185 Score = 87.8 bits (216), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 45/98 (45%), Positives = 63/98 (64%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 +IDG IA+++R+++ +V A + PGLAVVLVG SQ YV +K KACEE G Sbjct: 65 VIDGNVIAEEIRTKIISEVGKMKKAVGKVPGLAVVLVGEQRDSQTYVRNKIKACEETGIK 124 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLP 102 S +LPE +E +++ ++ N D +I GILVQLPLP Sbjct: 125 SVLAELPEDCTEGQIISVLRKFNEDTSIHGILVQLPLP 162 >UniRef50_B4FJK4 Putative uncharacterized protein n=1 Tax=Zea mays RepID=B4FJK4_MAIZE Length = 221 Score = 86.3 bits (212), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 49/101 (48%), Positives = 64/101 (63%), Gaps = 2/101 (1%) Query: 3 AKIIDGKTIAQQVRSEVAQKV-QARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A IIDGK+IA+ +R +A++V Q + + G PGLAVVLVG S+ YV K K CEEV Sbjct: 95 ASIIDGKSIAEDMRLHIAEEVCQMKCSVG-HVPGLAVVLVGDRRDSESYVRYKTKGCEEV 153 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLP 102 G S LP SE E+++ + N D ++ GILVQLPLP Sbjct: 154 GIKSLLAKLPGNCSEDEVMDSVSRFNEDPSVHGILVQLPLP 194 >UniRef50_D1Z754 Whole genome shotgun sequence assembly, scaffold_7 n=2 Tax=Sordariaceae RepID=D1Z754_SORMA Length = 386 Score = 85.9 bits (211), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 89/318 (27%), Positives = 138/318 (43%), Gaps = 59/318 (18%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 K+I TIA+++ SEV + + P LA L +P++ Y +K CEE GF Sbjct: 55 KVILSDTIAKKLLSEVRETLAKIQGPDASKPTLAAFLATDDPSALQYAEWSKKTCEENGF 114 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAG--IDNVKVLERIHPDKDVD 121 ++DL + E +L E I N D+ +DGILV P+ G + + E + KDV+ Sbjct: 115 ---NFDLRKVNKE-DLEESIIAANNDDNVDGILVYYPIWVGNHSQDKYIKETVALSKDVE 170 Query: 122 G------FHPYNVGRLCQRAPRLR----PCTPRGIVTLLER---------YNIDTFGLNA 162 G F+ Y+ R L+ PCTP IV LE Y FG Sbjct: 171 GLCHTHLFNMYHNVRFLDPPANLKKSILPCTPLAIVKTLEYLQIYNPILAYGNRLFGKTI 230 Query: 163 VVIGASNIVGRPMSMELLLAGCT-----TTVTHRFT-----KNLRHHVEN---------- 202 VI S + GRP++ L G T T FT + LRH V + Sbjct: 231 TVINRSEVNGRPLAALLANDGATVYSVDVTGVQVFTRGEGIRQLRHQVHDKEGWELKDVL 290 Query: 203 --ADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPV 259 +D++I V F +P + +++GA+ I+ + +G V + +AS P Sbjct: 291 PLSDVVIGGVPTEKFKVPTELLRDGAVCINFSSFKNFDGPAVKE--------KASIYVP- 341 Query: 260 PGGVGPMTVATLIENTLQ 277 +G +T+A L+ N ++ Sbjct: 342 --SIGKVTIAVLLRNLVR 357 >UniRef50_UPI0001904966 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Rhizobium etli RepID=UPI0001904966 Length = 175 Score = 83.6 bits (205), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 47/97 (48%), Positives = 59/97 (60%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 +IDGK +A V V A + GLAV++VG +PAS YV SK + +E GF Sbjct: 4 VIDGKNVAASVIQTVKSATAALEKSSGVTTGLAVIIVGDDPASHAYVGSKGRMAKECGFK 63 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPL 101 S + LP TS+AEL L+ TLNAD +I GILVQLPL Sbjct: 64 SVQHTLPAETSQAELAALVATLNADPSIHGILVQLPL 100 >UniRef50_B6FPJ6 Putative uncharacterized protein n=1 Tax=Clostridium nexile DSM 1787 RepID=B6FPJ6_9CLOT Length = 91 Score = 79.7 bits (195), Expect = 1e-13, Method: Composition-based stats. Identities = 36/79 (45%), Positives = 54/79 (68%) Query: 200 VENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPV 259 V AD+++ A+G+ + +W+K+G +VIDV +NR +NGK+ GDV D ++ SYITPV Sbjct: 6 VRQADIVVSAMGQAKLVKKEWLKQGTVVIDVEMNRDKNGKLCGDVELNDVMEKVSYITPV 65 Query: 260 PGGVGPMTVATLIENTLQA 278 G G +T A L+EN +QA Sbjct: 66 SKGDGFVTRAMLLENIMQA 84 >UniRef50_UPI00005A5066 PREDICTED: similar to Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor n=1 Tax=Canis lupus familiaris RepID=UPI00005A5066 Length = 239 Score = 76.3 bits (186), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 48/98 (48%), Positives = 64/98 (65%), Gaps = 8/98 (8%) Query: 188 VTHRFT--KNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINR-----LENGKV 240 ++H++T + L+ A+++I AVG I D IKEGA +I+VGINR L K+ Sbjct: 98 LSHQYTPKEQLKKCTVLAEIVISAVGILNLITADIIKEGAALINVGINRVQDPILSKAKL 157 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 VGDV FE K A+YITPV GVGPMTVA L++NT+ A Sbjct: 158 VGDVDFEGIRKNANYITPV-WGVGPMTVAMLMKNTIIA 194 >UniRef50_Q6UB35 Monofunctional C1-tetrahydrofolate synthase, mitochondrial n=54 Tax=cellular organisms RepID=C1TM_HUMAN Length = 978 Score = 74.7 bits (182), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 57/209 (27%), Positives = 100/209 (47%), Gaps = 8/209 (3%) Query: 34 PGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTID 93 P LA++ G + Q + EE G LP +SEAE+++ I +N D + Sbjct: 98 PVLAIIQAGDDNLMQ---EINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVH 154 Query: 94 GILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTP--RGIVTLLE 151 G+ +Q+ + + KVL + P+KDVDG N+G+L + +P + ++ LLE Sbjct: 155 GLALQIS--ENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLE 212 Query: 152 RYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVG 211 + ++ G +V+GA + + G T T+ L+ + AD++++ Sbjct: 213 KSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSP 272 Query: 212 KPGFIPGDWIKEGAIVIDVGINRLENGKV 240 KP IP WI+ G V++ + L +GKV Sbjct: 273 KPEEIPLTWIQPGTTVLNCSHDFL-SGKV 300 >UniRef50_Q4PBA5 Putative uncharacterized protein n=3 Tax=Basidiomycota RepID=Q4PBA5_USTMA Length = 607 Score = 74.3 bits (181), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 97/391 (24%), Positives = 141/391 (36%), Gaps = 123/391 (31%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 K+I IA + + + +QARI G P L +L +P S Y RKACE VG Sbjct: 223 KLIQASGIAAPYQDAIKEAIQARIQQGKSRPKLVGILATPSPPSVAYAEWTRKACEAVGI 282 Query: 64 ---VSRSYD-------------LPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDN 107 + +++D P+ EA++ +LI NAD + GI+V P+ G + Sbjct: 283 EFEIWKTWDDSVEVKEEDHKGSAPDFDLEADVEDLIIAANADEKVHGIMVYYPIFFGRQD 342 Query: 108 VKVLERIHPDKDVDGFH---------------PYNVGRLC--------QRAPR------- 137 + + + P KDV+G H P +G +RA R Sbjct: 343 TYLQQIVDPRKDVEGLHFSYCWNMYHNVRWISPAKLGNAPGTTRELPEERASREALDGEQ 402 Query: 138 --------LRPCTPRGIVTLLER---------YNIDTFGLNAVVIGASNIVGRPMSMELL 180 + PCTP +V LE Y +G VI S +VGRP++ L Sbjct: 403 VPPGMAKSILPCTPLAMVKCLEAIGVYDRDLPYGDRLYGKTITVINRSEVVGRPLAALLS 462 Query: 181 LAGCTTTVT-----HRFTK----------------------------NLR-HHV------ 200 G F K LR HHV Sbjct: 463 NDGAKVYSVDIDSIQEFNKRAVEPSSEPQGRARSEIVKEARAQNTASQLRPHHVVRNCSM 522 Query: 201 ------ENADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRA 253 +D++I V + I +WIK GA+ ++ + N K D RA Sbjct: 523 TAEECIRASDVVIAGVPSANYKIETEWIKPGAVCVNFSSEK--NFK-------SDVRTRA 573 Query: 254 SYITPVPGGVGPMTVATLIENTLQACVEYHD 284 S P +G T+A L N L+ VEY + Sbjct: 574 SMYLP---AIGKTTIAMLQRNLLR-LVEYRE 600 >UniRef50_UPI000023D48A hypothetical protein FG10624.1 n=1 Tax=Gibberella zeae PH-1 RepID=UPI000023D48A Length = 302 Score = 70.9 bits (172), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 60/254 (23%), Positives = 109/254 (42%), Gaps = 35/254 (13%) Query: 34 PGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTID 93 P +AVV + + YV K G Y++P S +++ + LN + I Sbjct: 45 PVMAVVYFNTGADAIDYVKIKAHVAARAGVSYWVYEMPVDASTTQVMTQVKKLNKNPRIH 104 Query: 94 GILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERY 153 GIL+Q PLP ++ +V+ I+P K+++ + + A +V LL +Y Sbjct: 105 GILIQRPLPRQLNEPEVMRSINPIKNIEEYAKGRANNIAADA----------LVRLLTKY 154 Query: 154 NIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENAD-------LL 206 + A + + G +T F K ++ + ++ Sbjct: 155 GLRESAQQA---------------RIQIVGFGNIITKEFIKQMKSQFPYMEVEAPRDSII 199 Query: 207 IVAVGK-PGFIPGDWIK-EGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVG 264 I + + PGFI +K E ++++D+G E G V+GDV + + I P PGGV Sbjct: 200 ISELHRGPGFIKSSMVKSEVSVLVDLGFYVTEKG-VLGDVSHVLFDRSSLAIAPTPGGVL 258 Query: 265 PMTVATLIENTLQA 278 P+ + ++E T++A Sbjct: 259 PILLWIMMERTIKA 272 >UniRef50_A9EVL6 Methylenetetrahydrofolate dehydrogenase (NAD(+)) n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9EVL6_SORC5 Length = 324 Score = 70.9 bits (172), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 81/318 (25%), Positives = 127/318 (39%), Gaps = 58/318 (18%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A ++D +A+ RSE+ +A +AA L VL + S Y RKACE+VG Sbjct: 25 ASVLDPTAVAETFRSEI----RAELAALPEPLVLVGVLAADHGPSYTYAEYTRKACEDVG 80 Query: 63 FVSRSYDLPETTS-EAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 +++ T +AE E I N D + G++V P+ +V + + + P KD++ Sbjct: 81 V---RFEIRHATRLDAE--EAIRAANEDARVHGMMVYYPIFGTEQDVYLRDSVDPAKDIE 135 Query: 122 GFHPYNVGRLCQRAPRLR---------PCTPRGIVTLLERYNI------DTFGLNAVVIG 166 G H + L Q L PCTP I+ L+E G + Sbjct: 136 GLHTFWARCLYQNQRFLDEAKTRKAILPCTPLAILKLVEAAGFFGEGERPLEGRRVCIFN 195 Query: 167 ASNIVGRPMSMELLLAGCTTTV-------------------THRFTKNLRHHVENADLLI 207 S +VGRP++ + G T T + + AD+++ Sbjct: 196 RSEVVGRPLASMMAHDGAHVTSFDIDGPLLFVPSSSGDMHEVRETTVDRATALRQADIVV 255 Query: 208 VAVGKPGF--IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGP 265 V F + G I+EGA+ I+ + +N +D +AS P VGP Sbjct: 256 TGVPSRSFPVVQGAEIREGALCIN--FSTFKNFS-------DDIQSKASVFVP---RVGP 303 Query: 266 MTVATLIENTLQACVEYH 283 MTV I N+L+ H Sbjct: 304 MTVTMAIRNSLRLYKNTH 321 >UniRef50_A4HZR2 Methylenetetrahydrofolate dehydrogenase-like protein n=3 Tax=Leishmania RepID=A4HZR2_LEIIN Length = 475 Score = 70.9 bits (172), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 50/145 (34%), Positives = 70/145 (48%), Gaps = 20/145 (13%) Query: 160 LNAVVIGASNIVGRPMSMELLLAGC-TTTVTHRFTK--NLRHHVENADLLIVAVGKPGFI 216 L+AV++ S +VG P + L AG T+ R +RH + AD+LI A G Sbjct: 294 LHAVIVNNSRVVGVPTAALLQCAGSFAVTLCSRSNSLDTIRHVAQQADVLITAYGAANVF 353 Query: 217 PGDWIKEGAIVIDVGINRL-----------ENG------KVVGDVVFEDAAKRASYITPV 259 +++EGAIVID +N L E G + GDV + A+ IT Sbjct: 354 DRSFVREGAIVIDAAVNELPEMTCQKEAAAETGGSARKKGICGDVDINSVSAVAAAITKT 413 Query: 260 PGGVGPMTVATLIENTLQACVEYHD 284 PGGVGP+T + L+ N L+A HD Sbjct: 414 PGGVGPLTASHLMFNVLKAYQLRHD 438 Score = 70.1 bits (170), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 50/138 (36%), Positives = 73/138 (52%), Gaps = 4/138 (2%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 +A+++ G I++++R Q+++ + R P L VVLVG + YV KR+A E Sbjct: 31 SAELLSGVPISKELR----QRIRTSTSVLRRPPCLVVVLVGDRADAIRYVNHKRRAAAEC 86 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G L T + EL + ++N D +D +L+QLPLP + L IHP KDVD Sbjct: 87 GIEVHLVHLSATIQQVELHRTLASVNDDVEVDAVLLQLPLPPHLRTRPALLHIHPGKDVD 146 Query: 122 GFHPYNVGRLCQRAPRLR 139 G HP N G LC + R R Sbjct: 147 GLHPLNAGSLCLQDQRSR 164 >UniRef50_C4QVL0 NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase n=14 Tax=Saccharomyceta RepID=C4QVL0_PICPG Length = 389 Score = 69.7 bits (169), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 66/271 (24%), Positives = 113/271 (41%), Gaps = 49/271 (18%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A K I TIA++ E+ V +++A P L +L +PA++ Y + CE + Sbjct: 80 AGKTILASTIAKKYSEELTS-VTSKMAT---KPKLVGLLGNQDPAAKTYAEWTARTCESL 135 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 GF P+ E E+ + N D+ ++GI+V P+ + + + + +KDV+ Sbjct: 136 GFQYELIQCPKENLEDEIYK----CNQDDAVNGIMVYFPVYNDGQDQYLQQCVSIEKDVE 191 Query: 122 GFHPYNVGRLCQR-----APR-----LRPCTPRGIVTLLER---------YNIDTFGLNA 162 G + V + AP + PCTP +V +LE Y FG Sbjct: 192 GLNFKYVSNMYHNIRYLDAPENTKKSILPCTPLAMVKILEYLGVYNTLLPYGNRLFGKTI 251 Query: 163 VVIGASNIVGRPMSMELLLAGCTTTV------------------THRFTKN---LRHHVE 201 ++ S IVGRP++ L G T +HR L+ Sbjct: 252 TIVNRSEIVGRPLAALLANDGATVYSVDINNVQKFERGDGLQLKSHRVVDTEFELKDVAP 311 Query: 202 NADLLIVAVGKPGF-IPGDWIKEGAIVIDVG 231 +D++I V + P +++K+GA+VI+ Sbjct: 312 KSDVIITGVPSSNYKFPLEYVKDGAVVINFS 342 >UniRef50_UPI0000D9A063 PREDICTED: similar to Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor n=1 Tax=Macaca mulatta RepID=UPI0000D9A063 Length = 198 Score = 66.2 bits (160), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 51/154 (33%), Positives = 70/154 (45%), Gaps = 10/154 (6%) Query: 94 GILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERY 153 G LVQLPL D K+ PDK VD F NVG C + T + +++ Sbjct: 31 GHLVQLPLAGHTDERKICNAFSPDKGVDDFPVMNVGLKCLDQYSMLLATRWDVRETIKQT 90 Query: 154 NIDTFGLNAVVIGASNIVGRPMSMELLLAG--------CTTTVTHRFTKN--LRHHVENA 203 ++ VV G S IV P+ M L + G T ++ ++ N L+ H A Sbjct: 91 DVPILEKTVVVAGRSKIVRMPIVMSLHIDGAHERPRDDATVIISPGYSPNEQLKKHKIFA 150 Query: 204 DLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 D + A G P D IKE A VIDVGI R+++ Sbjct: 151 DSVTSAAGIPSLFTIDIIKERAAVIDVGITRVQD 184 >UniRef50_A1ZUI3 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZUI3_9SPHI Length = 233 Score = 65.9 bits (159), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 55/218 (25%), Positives = 98/218 (44%), Gaps = 48/218 (22%) Query: 82 LIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPC 141 +ID+LN D I ++VQ P P G++N+ +++++P KD+D R+ P Sbjct: 1 MIDSLNKDTNIGAVIVQSPPPKGLENI--VKKLNPKKDLDALSGDKKNRMFPY-----PA 53 Query: 142 TPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHV- 200 T GIV ++E + + + + + +T K ++ H+ Sbjct: 54 TSEGIVRIVEPF--------------AEAGKKIVVVGGGGFIGEGVITMLKEKGIKPHII 99 Query: 201 ------------------ENADLLIVAVGKPGFIPGDWIKEG-AIVIDVG------INRL 235 +N D++I VGK G I G +K+ +++D G +++L Sbjct: 100 DPRVIDDPGYQGKDLALMKNYDIIISTVGKEGLIKGKDLKDDHTLIVDTGFVPLENVDKL 159 Query: 236 ENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIE 273 + V GDV A + ++TPVPGG GP+ +A L+E Sbjct: 160 TSKNVKGDV-DPTAKNKTKFVTPVPGGTGPVEMAVLME 196 >UniRef50_B0CXH2 Predicted protein n=1 Tax=Laccaria bicolor S238N-H82 RepID=B0CXH2_LACBS Length = 308 Score = 65.9 bits (159), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 85/322 (26%), Positives = 132/322 (40%), Gaps = 75/322 (23%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF- 63 ++ I+ R EV + ++A + P L +L S+ S Y RK CEE+GF Sbjct: 9 LLKADPISAAFRDEVKKDLEACSSR----PKLVGILATSSAPSNNYAEFTRKQCEELGFE 64 Query: 64 -------VSRSYDLP--ETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLER- 113 + S DL E EA +ID N D+++ GI+V P+ G+ L++ Sbjct: 65 FVLKKTGAALSSDLAAGEGVEEA----IIDA-NEDDSVHGIMVYYPI-FGVQQDHYLQQV 118 Query: 114 IHPDKDVDGFH---PYNVGRLCQRAP----RLRPCTPRGIVTLLER---------YNIDT 157 + P KDV+G H YN+ + P + PCTP IV LE Y Sbjct: 119 VSPLKDVEGLHFKFHYNLYHKYEPPPGTVKSIIPCTPLAIVKCLEFVGVYNTILPYGDRA 178 Query: 158 FGLNAVVIGASNIVGRPMSMELLLAGCT--------------TTVTHRFTKNLRHHVEN- 202 +G VI S +VGRP++ L G +T+ ++ H N Sbjct: 179 YGKTITVINRSEVVGRPLAALLANDGARVLSVDIDSIHVPYFSTLAQKYHPRHIVHPSNL 238 Query: 203 --------ADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFE-DAAKR 252 +D+++ AV P + + +K+G I ++V D FE D + Sbjct: 239 TLEECLAISDVVVSAVPSPSYKVKTALLKDGCICLNVA----------SDKNFEKDVRDK 288 Query: 253 ASYITPVPGGVGPMTVATLIEN 274 AS P VG +T+ L+ N Sbjct: 289 ASLYIP---AVGKVTILMLLRN 307 >UniRef50_A6QZK7 Putative uncharacterized protein n=1 Tax=Ajellomyces capsulatus NAm1 RepID=A6QZK7_AJECN Length = 297 Score = 61.2 bits (147), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 64/252 (25%), Positives = 106/252 (42%), Gaps = 49/252 (19%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 + K++ +A+ + +EV + Q A P L L S+PA+++Y K C++ Sbjct: 12 SCKVVLAANVARGLLAEVNEGRQTLSTA----PHLVGFLANSDPAAKMYADWTEKTCKDN 67 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 F Y L T S ++ + I N+D +DGI+V P+ + + + + KDV+ Sbjct: 68 NF---RYTL-RTVSRDDIEDAILVANSDPDVDGIIVYYPIFNNRQDQYLQQIVDISKDVE 123 Query: 122 G------FHPYNVGRLC----QRAPRLRPCTPRGIVTLLER---------YNIDTFGLNA 162 G F+ Y R + + PCTP ++ +LE Y FG Sbjct: 124 GLSHRYIFNMYQNIRFLDPPENKQKSILPCTPLAVIKILEYLQIYNTILPYGNRLFGHTI 183 Query: 163 VVIGASNIVGRPMSMELLLAG-CTTTV----THRFTK----NLRHH-------------V 200 V+ S +VGRP++ L G C +V +FT+ RHH Sbjct: 184 CVVNRSEVVGRPLAALLANDGACVYSVDVTGVQQFTRGEGIRKRHHEVMDMEGNFGPEVK 243 Query: 201 ENADLLIVAVGK 212 E A + + A+GK Sbjct: 244 EKASIYVPAIGK 255 >UniRef50_Q4S6Y9 Chromosome 14 SCAF14723, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4S6Y9_TETNG Length = 1066 Score = 60.8 bits (146), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 57/256 (22%), Positives = 106/256 (41%), Gaps = 21/256 (8%) Query: 34 PGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTID 93 P LA++ G + + +K +G L + SE E++ + L+ D + Sbjct: 23 PSLAIIQAGEDDG---LLEINKKMARRIGLNVTQICLAKECSEIEIVTEVLKLSEDPGVH 79 Query: 94 GILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQ--RAPRLRPCTPRGIVTLLE 151 G+ + LP A + + +VL + P+KDVDG N G L + + P ++ L Sbjct: 80 GLYLHLP-QASLTS-RVLTALKPEKDVDGLSDLNTGCLIRGDLSAGFVPPVTSAVLEWLS 137 Query: 152 RYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVG 211 ++++ G +++G + + G V+ +KNL+ V AD ++V Sbjct: 138 KHHVTLEGKTVLILGGHGTFEVTLRCLIERQGIEVVVSDWTSKNLKSQVMRADAVVVLEA 197 Query: 212 KPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATL 271 +P W K GA+V + E A+ +S G+G +T A Sbjct: 198 GKKNLPPTWFKPGALVFSCDPTSKTD---------ESVAESSSN-----SGLGYLTAAYR 243 Query: 272 IENTLQACVEYHDPQD 287 ++N Q+C + Q+ Sbjct: 244 MKNVAQSCGRWLQEQE 259 >UniRef50_Q0UVW9 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum RepID=Q0UVW9_PHANO Length = 292 Score = 60.5 bits (145), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 80/309 (25%), Positives = 123/309 (39%), Gaps = 82/309 (26%) Query: 11 IAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDL 70 +A + + ++V+ ++ R P L L S+PA+++Y K C E GF ++DL Sbjct: 12 LANNIAKSLLEEVRDGLSKIERKPLLVGFLSSSDPAARVYAEWTGKTCTENGF---AFDL 68 Query: 71 PETTSEAELLE--LIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG------ 122 E + ELLE LID N D + DKDV+G Sbjct: 69 REV--DRELLEDALIDANNDDKI----------------------VSIDKDVEGLSHRYI 104 Query: 123 FHPYNVGRLCQRA---PRLRPCTPRGIVTLLER---------YNIDTFGLNAVVIGASNI 170 F+ Y R A + PCTP ++ +LE Y G VI S + Sbjct: 105 FNMYQNIRFLDPANTKKSILPCTPLAVIKILEYLRIYNTILPYGNRLHGRTITVINRSEV 164 Query: 171 VGRPMSMELLLAG-CTTTV----THRFTKNL-----RHHVENADLLIVAVGKPGFIPGDW 220 VGRP++ L G C +V FT+ + RH V V KPG+ D Sbjct: 165 VGRPLAALLANDGACVYSVDISDVQEFTRGVGLRKRRHEV---------VDKPGWTLDDC 215 Query: 221 IKEGAIVID--------VGINRLENGKVVGDVVFE-----DAAKRASYITPVPGGVGPMT 267 + +VI V + ++ +G V + E + ++AS P +G +T Sbjct: 216 LPLSDVVISGVPGDKYKVPLEKMRDGAVCINFSSERNFTPEVKEKASIYVP---AIGKVT 272 Query: 268 VATLIENTL 276 +A L+ N L Sbjct: 273 IAVLLRNLL 281 >UniRef50_B8BYF8 Predicted protein n=1 Tax=Thalassiosira pseudonana RepID=B8BYF8_THAPS Length = 370 Score = 59.7 bits (143), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 80/324 (24%), Positives = 129/324 (39%), Gaps = 54/324 (16%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 AK ID IA+ R E+ +V AG+ AP L +L ++PA++ Y KAC G Sbjct: 15 AKKIDAGDIAKPFREEIRNQVAKLKQAGIDAPLLVGLLANTDPAAKKYAEWTGKACRADG 74 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVK-------VLERIH 115 Y+L ++ + N D + GI+V P+ +++ + + + Sbjct: 75 I---RYELRMIDDPIDVEAALCDANDDPRVHGIIVYYPIFGQVESFSGESQDDYLRDTVS 131 Query: 116 PDKDVDGF-HPY--NVGRLCQRAPR------LRPCTPRGIVTLLER----YNIDT----- 157 DV+G H Y N+ R + R + PCT +V +LE Y+ Sbjct: 132 HKCDVEGLCHQYRSNLYRNVRYMDRNHTKKCVLPCTALSVVKILESCESCYDKSKPIGRH 191 Query: 158 -FGLNAVVIGASNIVGRPMSMELLLAGCTTT-----VTHRFTKNLRHHVE---------N 202 G +I S IVGRP++ L G + F H E Sbjct: 192 MEGQTVTIINRSEIVGRPLAAMLANDGADVYSIDIDSIYLFRGGKLHKCEGETPESCVRK 251 Query: 203 ADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPG 261 + ++I V + +P +WIK V++V +N V ED + + +P Sbjct: 252 STVVITGVPTKNYRLPSEWIKPNTTVVNVA--SFKN-------VNEDEILQIEGVQYIP- 301 Query: 262 GVGPMTVATLIENTLQACVEYHDP 285 VG +TVA L N ++ +H P Sbjct: 302 MVGKVTVAMLERNLMRLFYNFHHP 325 >UniRef50_B8NT34 Methylenetetrahydrofolate dehydrogenase, putative n=2 Tax=Aspergillus RepID=B8NT34_ASPFN Length = 307 Score = 58.9 bits (141), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 67/282 (23%), Positives = 113/282 (40%), Gaps = 62/282 (21%) Query: 39 VLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQ 98 VL + S Y RK C+E+G L S + I +NA+N++ GI+V Sbjct: 38 VLASDDAGSNQYANWTRKTCQEIGVHFHLMKL----SPKNVATYIRAINANNSVHGIIVY 93 Query: 99 LPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLR---------PCTPRGIVTL 149 P+ + ++ + + P KDV+G + + R+ A R PCTPR + + Sbjct: 94 YPIFGDRRDDEIRQLVAPSKDVEGLNHQTLHRISDAAEVSRPPKPGRNVIPCTPRAVAWI 153 Query: 150 LERYNIDTFGLNA---------VVIGASNIVGRPMSMELLLAGCTTTV-------THRFT 193 LE ++ A +I S +VG P++ LLAG V F Sbjct: 154 LEWMDVHDRTRPAGERLQNQEICIINRSEVVGLPLAH--LLAGEGARVYSVDISGVQLFQ 211 Query: 194 K------------------NLRHHVENADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINR 234 + +++ V+ + ++I AV P F + W++ GAI ++V + Sbjct: 212 RLYYPWQSEALHGKDLPNWSVQDAVQRSRVVISAVPDPAFRVNTKWLQRGAICVNVSSEK 271 Query: 235 LENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 VV + AS P VG +T+ L+ N + Sbjct: 272 NFEANVV---------EVASKFVP---RVGSVTIGALLYNLI 301 >UniRef50_Q86KU6 Methylenetetrahydrofolate dehydrogenase [NAD+] n=1 Tax=Dictyostelium discoideum RepID=MTD1_DICDI Length = 313 Score = 57.4 bits (137), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 71/313 (22%), Positives = 124/313 (39%), Gaps = 64/313 (20%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG--F 63 +D IA R EV Q +I P + L + + Y + AC++ G F Sbjct: 15 VDVTPIANFFREEVKQ----QITKNCWKPRVVAFLTSDDQGAIDYSKWTKLACQKDGIEF 70 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG- 122 + + + +L +LI N D+ + GILV P+ G+ + + + + P KD++G Sbjct: 71 ILKRVE------RVDLEDLIIEANNDSCVHGILVYYPVFGGMMDSYLQDVVSPTKDIEGL 124 Query: 123 -----FHPYNVGRLCQRAPRLR----PCTPRGIVTLLERYNI---------DTFGLNAVV 164 F+ Y+ R + PCTP +V +++ I G + Sbjct: 125 STQNRFNLYHNIRFMDGETATKKCVIPCTPLAMVKIIDNLGIYDKSLAMGEHLKGKTVTI 184 Query: 165 IGASNIVGRPMSMELLLAGCTTTVTH-----RFTKNLRH--------------HVENADL 205 + S IVGRP++ L G F RH + +D+ Sbjct: 185 VNRSEIVGRPLAAMLANDGAIVYSIDINGIIIFQSGKRHGTIKMSETNVTREEAISKSDI 244 Query: 206 LIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVG 264 LI+ V P + + D I++G IVI+ G + +++ + S + P +G Sbjct: 245 LILGVPSPNYKVNSDLIQDGTIVINFA----------GCLNVDESIQEKSILVPT---IG 291 Query: 265 PMTVATLIENTLQ 277 +T+A L N L+ Sbjct: 292 KVTIAMLERNLLR 304 >UniRef50_B1AIX6 Methylenetetrahydrofolate dehydrogenase n=15 Tax=Ureaplasma RepID=B1AIX6_UREP2 Length = 269 Score = 55.5 bits (132), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/241 (23%), Positives = 97/241 (40%), Gaps = 9/241 (3%) Query: 40 LVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQL 99 LV N A Y+ SK K + YDL + E + L N D + + Sbjct: 35 LVNFNSA---YIQSKLKYAKLFSVKLIIYDLNAYQIQ-ENHHFLSKLKQANK-DFLFFEF 89 Query: 100 PLPAGIDNVKVLERIHPDKDVDGFHPY-NVGRLCQRAPRLRPCTPRGIVTLLERYNIDTF 158 PL + + + D+DG + + + + + P T I+TL++ +++ Sbjct: 90 PLSKKHLDQNYFQYLTFQNDLDGINSHLFLNKKQENQIIYHPATINAILTLIKELDVNLN 149 Query: 159 GLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPG 218 +IG S +G + L + H TKN ++ ++ +I V K Sbjct: 150 DYRICIIGRSPYLGDYLYKLLNPKNNKINIIHSQTKNPLRIIKESNFIISCVNKAHIFNS 209 Query: 219 DWIKEGAIVIDVGINRLENGKVVGDVVFE--DAAKRASYITPVPGGVGPMTVATLIENTL 276 + + + + +IDV + N K+ G + DA R TPVPGG+G +T L N Sbjct: 210 NALSDNSYLIDVTTEYI-NNKLCGSFLINKNDALNRNIKYTPVPGGIGKLTTLFLFLNYF 268 Query: 277 Q 277 + Sbjct: 269 K 269 >UniRef50_Q5KEZ0 Methylenetetrahydrofolate dehydrogenase (NAD+), putative n=2 Tax=Agaricomycotina RepID=Q5KEZ0_CRYNE Length = 367 Score = 54.3 bits (129), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 91/373 (24%), Positives = 140/373 (37%), Gaps = 113/373 (30%) Query: 5 IIDGKTIAQQVRSEVAQKVQA-RIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +I +A +SE+ + + R ++ R P L +L ++ Y +KACE +G Sbjct: 6 LITASKVATPFKSELLSALASPRFSS--RPPHLVGILATKKEDARTYAEFTKKACETLGI 63 Query: 64 VSRSYDLPETTSEA-----------ELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLE 112 +Y+L EA E+ E I N D +DG++V P+ G + + Sbjct: 64 ---TYEL-RLVGEAREGMDGEGVGIEVEEAILEANEDPEVDGMMVYYPIYGGRQDQYLQS 119 Query: 113 RIHPDKDVDG---------FH-----------PYNVGRLCQRAP---------------- 136 + P KDV+G +H P L + P Sbjct: 120 VVSPQKDVEGLNHQFLFNLYHNVRFINPLTLRPIPASHLPEPLPSKSGDSSKGEDVAPEG 179 Query: 137 ---RLRPCTPRGIVTLLER---YN-IDTFGLNA-----VVIGASNIVGRPMSMELLLAGC 184 + PCTP IV +LE YN + +G A VI S +VGRP++ L G Sbjct: 180 TVKSILPCTPLAIVKVLEHIGVYNRLLAYGDRARGKVITVINRSEVVGRPLAALLANDGA 239 Query: 185 ---------TTTVTHRFTKNLR---------HHVEN-------------ADLLIVAVGKP 213 + R +K+ HH+ +D++I AV Sbjct: 240 RVISVDLDSIVEFSKRPSKSAEGKKPSSASPHHITTPLPDMTLHKALSFSDVVISAVPVD 299 Query: 214 GF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFE-DAAKRASYITPVPGGVGPMTVATL 271 F +P +K+G + ++V G+ FE D RAS P VG MT+ L Sbjct: 300 SFKVPTRELKDGCVCVNVA----------GEKNFETDVRDRASIYVP---SVGVMTITML 346 Query: 272 IENTLQACVEYHD 284 N L+ C EY D Sbjct: 347 QRNLLRLC-EYRD 358 >UniRef50_A8ZN24 Putative uncharacterized protein n=1 Tax=Acaryochloris marina MBIC11017 RepID=A8ZN24_ACAM1 Length = 482 Score = 54.3 bits (129), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 65/244 (26%), Positives = 106/244 (43%), Gaps = 33/244 (13%) Query: 39 VLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQ 98 L+ A++ K K + +G +L +T+ E L+ +N + ++VQ Sbjct: 45 TLLAKYEAARFSTEHKVKTFKALGCEVEHLNLDASTTSVEFGRLLKHVNKKSI--SVIVQ 102 Query: 99 LPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLR-PCTPRGIVTLLERYNIDT 157 P P D L I +KD+DG N P R T I ++E + + Sbjct: 103 NPFPE--DFKSWLSEISYEKDIDGLRRDN--------PFFRVSATSETIFRIVEPFAQE- 151 Query: 158 FGLNAVV--IGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGF 215 N VV +GA VG ++ L +G + + + A++++ A+G P Sbjct: 152 ---NDVVAVVGAEGFVGGGVTRLLEESGISVIGLDK--NDDLTLTRQANIVVSAMGSPNE 206 Query: 216 IPGDWI-KEGAIVIDVGINRLENGKVVGDVVFEDAAKRASY-----ITPVPGGVGPMTVA 269 + I E +V+D G L + ++GDV R++Y ITPVPGGVGP +A Sbjct: 207 LDERHIIPEHRLVVDSGFIPLADSPILGDV------NRSAYDIPLNITPVPGGVGPFQMA 260 Query: 270 TLIE 273 TL+E Sbjct: 261 TLME 264 >UniRef50_Q6X5D4 Methylene-THF dehydrogenase (Fragment) n=1 Tax=Treponema primitia RepID=Q6X5D4_9SPIO Length = 97 Score = 51.2 bits (121), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 31/96 (32%), Positives = 50/96 (52%), Gaps = 1/96 (1%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A+++DGK +A + + + V+A A G+ P L ++ +G Y K EEVG Sbjct: 2 AQLLDGKVVAAALAESLKKDVEALKAKGV-TPTLGIIRLGEKGPDISYEKGATKRAEEVG 60 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQ 98 ++Y LPE T++ LL++I N D + G L Q Sbjct: 61 AAVKNYILPEDTTQEALLKVIKEANDDKGVHGCLAQ 96 >UniRef50_B9PLA1 Methylenetetrahydrofolate dehydrogenase, putative n=3 Tax=Toxoplasma gondii RepID=B9PLA1_TOXGO Length = 630 Score = 50.8 bits (120), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 32/98 (32%), Positives = 56/98 (57%) Query: 140 PCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHH 199 PC ++ +L+ +++ G V+GAS VG+ +++ LL T + H T++L+ Sbjct: 358 PCVALAVLDILKAWDMSLAGAAVAVVGASPRVGQAIALLLLQRQATVCLCHSRTRDLKGI 417 Query: 200 VENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 + +D++I A G P I D ++ A VIDVG+N LE+ Sbjct: 418 LLRSDVIIAAAGSPHLISSDMVRPNAAVIDVGVNVLES 455 >UniRef50_Q5PNN5 Novel protein similar to methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofola (Mthfd1) (Fragment) n=3 Tax=Danio rerio RepID=Q5PNN5_DANRE Length = 263 Score = 47.0 bits (110), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 45/161 (27%), Positives = 71/161 (44%), Gaps = 16/161 (9%) Query: 11 IAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDL 70 I Q+ R E+ K GL+ P LA++ G + + +K ++G L Sbjct: 81 IVQRCREEL--KSIGENNPGLK-PTLAIIQAGEDDG---LLEMNKKMAGKIGLNVMQICL 134 Query: 71 PETTSEAELLELIDTLNADNTIDGILVQLP---LPAGIDNVKVLERIHPDKDVDGFHPYN 127 P +E E++E + LN D+ + GI + LP L + N I P KDVDG N Sbjct: 135 PHRCTEEEVIEEVLRLNKDSRVHGIFLHLPQTFLSKSVRNA-----IKPQKDVDGVCDLN 189 Query: 128 VGR--LCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIG 166 VGR L + ++ LL +++ G AV++G Sbjct: 190 VGRVVLGDKTDGFTSPVAGAVLELLAKHDAPLVGKMAVLVG 230 >UniRef50_B3L796 Putative uncharacterized protein n=2 Tax=Plasmodium (Plasmodium) RepID=B3L796_PLAKH Length = 614 Score = 47.0 bits (110), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 23/53 (43%), Positives = 35/53 (66%), Gaps = 5/53 (9%) Query: 186 TTVTHRFTKNLRHH-----VENADLLIVAVGKPGFIPGDWIKEGAIVIDVGIN 233 T +TH LR + V+N+DL+I+A+G P + +IKEGAI++D+GIN Sbjct: 372 TKITHHDLSTLRKNMHTRIVKNSDLIIMAIGCPHILKKKYIKEGAIILDLGIN 424 >UniRef50_UPI00015563B5 PREDICTED: similar to Mthfd2-prov protein, partial n=1 Tax=Ornithorhynchus anatinus RepID=UPI00015563B5 Length = 161 Score = 44.7 bits (104), Expect = 0.003, Method: Compositional matrix adjust. Identities = 27/59 (45%), Positives = 41/59 (69%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A +I G+ +A+Q+R EV +V+ +A+G + P L+V+LVG NPAS YV +K KA +V Sbjct: 47 AVVISGRKLARQIREEVRHEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTKAAADV 105 >UniRef50_Q3M1J6 Tetrahydrofolate dehydrogenase/cyclohydrolase n=3 Tax=Nostocaceae RepID=Q3M1J6_ANAVT Length = 396 Score = 42.7 bits (99), Expect = 0.015, Method: Compositional matrix adjust. Identities = 66/286 (23%), Positives = 109/286 (38%), Gaps = 40/286 (13%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNP---------ASQIYVASKR 55 +IDG+ I + V+ E QK ++ A + + N A++I K Sbjct: 3 LIDGQLIREHVKQE-CQKYKSIFQASQKEVAIIRFEASENASNGLRARYEAARISAEQKV 61 Query: 56 KACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGID-NVKVLERI 114 +G L + + +I ++N ++ + +VQ P+PA ++ +LE Sbjct: 62 ATFNAIGITPNYIVLSPNIAVEQFDNIIQSINENSKVTAAIVQYPIPAKFTTSIGLLE-- 119 Query: 115 HPDKDVD--GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVG 172 P KD+D N C T GI ++E Y + V G G Sbjct: 120 -PQKDIDIVRRQSNNFFESC--------ATAEGIARIVESYAQSDSNVAVVGGGGFVGNG 170 Query: 173 RPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGI 232 +E C + + AD+++ G+ G + +V+D G Sbjct: 171 VIKYLEASRISCFCLEDG----DDLSRTQAADIVVSVTGRQGIFTPYVLPSHRLVVDGGF 226 Query: 233 NRLENGKVVGDVVFEDAAKRASY-----ITPVPGGVGPMTVATLIE 273 +G GDV R++Y ITPVPGGVGP+ +A L E Sbjct: 227 TPTASG-AAGDV------DRSAYRIPQNITPVPGGVGPIEMAILAE 265 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_A0LE04 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 409 e-113 UniRef50_A7MT09 Methenyltetrahydrofolate cyclohydrolase n=64 Tax... 407 e-112 UniRef50_A5F6V4 Methenyltetrahydrofolate cyclohydrolase n=270 Ta... 403 e-111 UniRef50_Q0AB42 Methenyltetrahydrofolate cyclohydrolase n=19 Tax... 403 e-111 UniRef50_O65271 F6N23.26 protein n=34 Tax=Viridiplantae RepID=O6... 391 e-107 UniRef50_A3DEE6 Methenyltetrahydrofolate cyclohydrolase n=6 Tax=... 390 e-107 UniRef50_Q82XC3 Methenyltetrahydrofolate cyclohydrolase n=7 Tax=... 384 e-105 UniRef50_B5YJV1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 377 e-103 UniRef50_Q2JQ25 Methenyltetrahydrofolate cyclohydrolase n=8 Tax=... 374 e-102 UniRef50_B8HXS0 Methenyltetrahydrofolate cyclohydrolase n=25 Tax... 372 e-102 UniRef50_A8JH65 5,10-methylenetetrahydrofolate dehydrogenase n=4... 371 e-101 UniRef50_Q46A53 Methenyltetrahydrofolate cyclohydrolase n=13 Tax... 370 e-101 UniRef50_C4FUB1 Putative uncharacterized protein n=1 Tax=Catonel... 367 e-100 UniRef50_A4XY05 Methenyltetrahydrofolate cyclohydrolase n=47 Tax... 367 e-100 UniRef50_B0KLM9 Methenyltetrahydrofolate cyclohydrolase n=184 Ta... 366 e-100 UniRef50_Q8LEA3 5,10-methylenetetrahydrofolate dehydrogenase:5,1... 366 e-100 UniRef50_B2V9R3 Methenyltetrahydrofolate cyclohydrolase n=14 Tax... 366 e-100 UniRef50_A0K8R4 Methenyltetrahydrofolate cyclohydrolase n=254 Ta... 365 e-100 UniRef50_Q6GI21 Methenyltetrahydrofolate cyclohydrolase n=83 Tax... 364 2e-99 UniRef50_Q12V26 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=... 363 3e-99 UniRef50_Q6F9E6 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 362 1e-98 UniRef50_P13995 Methenyltetrahydrofolate cyclohydrolase n=52 Tax... 362 1e-98 UniRef50_A0M554 Methenyltetrahydrofolate cyclohydrolase n=88 Tax... 359 7e-98 UniRef50_P11586 Formyltetrahydrofolate synthetase n=378 Tax=root... 359 9e-98 UniRef50_D2QZP8 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 358 1e-97 UniRef50_C2E8X3 Methylenetetrahydrofolate dehydrogenase (NADP+)/... 356 4e-97 UniRef50_Q8DMU0 Methenyltetrahydrofolate cyclohydrolase n=80 Tax... 356 4e-97 UniRef50_UPI0001BC5140 bifunctional protein FolD n=3 Tax=Fusobac... 356 7e-97 UniRef50_B3ESU1 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 355 8e-97 UniRef50_Q11UD1 Methenyltetrahydrofolate cyclohydrolase n=6 Tax=... 355 1e-96 UniRef50_B0TFC9 Methenyltetrahydrofolate cyclohydrolase n=7 Tax=... 355 1e-96 UniRef50_Q17W13 Methenyltetrahydrofolate cyclohydrolase n=14 Tax... 354 2e-96 UniRef50_C7TD85 5,10-methylene-tetrahydrofolate dehydrogenase/me... 352 6e-96 UniRef50_A9A4N5 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=... 351 1e-95 UniRef50_Q1II76 Methenyltetrahydrofolate cyclohydrolase n=15 Tax... 349 5e-95 UniRef50_D0GMJ6 Bifunctional protein FolD n=2 Tax=Leptotrichia R... 349 6e-95 UniRef50_B2S3X1 Methenyltetrahydrofolate cyclohydrolase n=35 Tax... 349 7e-95 UniRef50_Q1QD30 Methenyltetrahydrofolate cyclohydrolase n=50 Tax... 348 1e-94 UniRef50_Q049N0 Methenyltetrahydrofolate cyclohydrolase n=18 Tax... 348 1e-94 UniRef50_A5VAA8 Methenyltetrahydrofolate cyclohydrolase n=107 Ta... 348 1e-94 UniRef50_Q9X7F6 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 348 2e-94 UniRef50_Q8RAD0 Methenyltetrahydrofolate cyclohydrolase n=11 Tax... 347 3e-94 UniRef50_B1GZ24 Bifunctional protein FolD n=2 Tax=Bacteria RepID... 346 5e-94 UniRef50_UPI00015B59A5 PREDICTED: similar to ENSANGP00000016878 ... 345 9e-94 UniRef50_D0MY89 Bifunctional folD protein n=1 Tax=Phytophthora i... 345 1e-93 UniRef50_Q9H903 Methenyltetrahydrofolate cyclohydrolase n=75 Tax... 342 5e-93 UniRef50_C8P269 Methylenetetrahydrofolate dehydrogenase/methenyl... 342 8e-93 UniRef50_C5BI30 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=... 342 9e-93 UniRef50_D0J906 Putative methenyltetrahydrofolate cyclohydrolase... 341 1e-92 UniRef50_B8C1N0 5, 10-methylenetetrahydrofolate dehydrogenase n=... 341 2e-92 UniRef50_UPI0000DB7ABF PREDICTED: similar to Bifunctional methyl... 341 2e-92 UniRef50_A5V1H2 Methenyltetrahydrofolate cyclohydrolase n=7 Tax=... 341 2e-92 UniRef50_Q2GLF2 Methenyltetrahydrofolate cyclohydrolase n=41 Tax... 340 3e-92 UniRef50_A2BX55 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=... 340 3e-92 UniRef50_C8PLX3 Bifunctional protein FolD n=1 Tax=Treponema vinc... 340 5e-92 UniRef50_C3K8G7 Putative histidine biosynthesis-related tetrahyd... 339 6e-92 UniRef50_A8GNK0 Methenyltetrahydrofolate cyclohydrolase n=15 Tax... 339 7e-92 UniRef50_B0S8U6 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=... 339 7e-92 UniRef50_Q18GK1 Methenyltetrahydrofolate cyclohydrolase n=15 Tax... 339 8e-92 UniRef50_B1ZYH0 Methenyltetrahydrofolate cyclohydrolase n=8 Tax=... 339 1e-91 UniRef50_C8P9U1 Putative uncharacterized protein folD2 n=1 Tax=L... 338 1e-91 UniRef50_Q2SRE7 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=... 337 3e-91 UniRef50_UPI00016C0DE6 Methenyltetrahydrofolate cyclohydrolase n... 337 3e-91 UniRef50_Q03RR1 Methenyltetrahydrofolate cyclohydrolase n=22 Tax... 337 4e-91 UniRef50_A9HEL1 Methenyltetrahydrofolate cyclohydrolase n=82 Tax... 336 6e-91 UniRef50_C1XHV3 5,10-methylenetetrahydrofolate dehydrogenase (NA... 336 6e-91 UniRef50_A8ZTQ4 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=... 335 7e-91 UniRef50_D1AX33 Methylenetetrahydrofolate dehydrogenase (NADP(+)... 335 8e-91 UniRef50_C5R8B8 Bifunctional protein: methylenetetrahydrofolate ... 334 1e-90 UniRef50_Q14NV1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 333 5e-90 UniRef50_D0N1V3 Bifunctional folD protein n=1 Tax=Phytophthora i... 331 2e-89 UniRef50_C8PD95 Putative uncharacterized protein folD n=1 Tax=La... 330 5e-89 UniRef50_A6LU44 Methenyltetrahydrofolate cyclohydrolase n=22 Tax... 329 6e-89 UniRef50_A8IFV5 5,10-methylenetetrahydrofolate dehydrogenase (Fr... 329 1e-88 UniRef50_Q4T2B9 Chromosome undetermined SCAF10300, whole genome ... 327 4e-88 UniRef50_Q189R8 Methenyltetrahydrofolate cyclohydrolase n=26 Tax... 326 6e-88 UniRef50_Q254F7 Methenyltetrahydrofolate cyclohydrolase n=13 Tax... 324 3e-87 UniRef50_C5C958 Methenyltetrahydrofolate cyclohydrolase n=118 Ta... 323 5e-87 UniRef50_A5N5B5 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=... 322 6e-87 UniRef50_C8W0Y6 Methylenetetrahydrofolate dehydrogenase (NADP(+)... 322 7e-87 UniRef50_D0N1T3 Bifunctional folD protein n=1 Tax=Phytophthora i... 322 1e-86 UniRef50_C0GE27 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 322 1e-86 UniRef50_D1CB15 Methylenetetrahydrofolate dehydrogenase (NADP(+)... 320 2e-86 UniRef50_C7N2I9 Methenyltetrahydrofolate cyclohydrolase /5,10-me... 320 3e-86 UniRef50_UPI00017F08E4 PREDICTED: similar to MGC137793 protein n... 319 1e-85 UniRef50_C9LM47 Methylenetetrahydrofolate dehydrogenase/methenyl... 318 1e-85 UniRef50_Q7TU81 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 318 2e-85 UniRef50_C4FZX7 Putative uncharacterized protein n=1 Tax=Abiotro... 318 2e-85 UniRef50_C6LCK2 Methylenetetrahydrofolate dehydrogenase/methenyl... 314 3e-84 UniRef50_A8SN78 Putative uncharacterized protein n=1 Tax=Parvimo... 313 5e-84 UniRef50_Q057D7 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=... 311 1e-83 UniRef50_C0R292 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=... 310 2e-83 UniRef50_A9NE96 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 310 3e-83 UniRef50_D2RNA3 Methylenetetrahydrofolate dehydrogenase (NADP(+)... 310 3e-83 UniRef50_O65269 F6N23.28 protein n=1 Tax=Arabidopsis thaliana Re... 310 3e-83 UniRef50_Q21285 Dauer or aging adult overexpression protein 3, c... 310 3e-83 UniRef50_C4Z3I2 Methylenetetrahydrofolate dehydrogenase (NADP+) ... 309 6e-83 UniRef50_D1C3C2 Methylenetetrahydrofolate dehydrogenase (NADP(+)... 309 1e-82 UniRef50_Q83FS2 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 308 1e-82 UniRef50_Q0S375 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=... 308 1e-82 UniRef50_B0VGJ7 FolD bifunctional protein n=1 Tax=Candidatus Clo... 307 4e-82 UniRef50_A8RJW5 Putative uncharacterized protein n=2 Tax=Clostri... 306 7e-82 UniRef50_C7MLE6 Methenyltetrahydrofolate cyclohydrolase /5,10-me... 305 8e-82 UniRef50_C1FDF4 5,10-methylene-tetrahydrofolate dehydrogenase/cy... 305 1e-81 UniRef50_A5CF58 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 305 1e-81 UniRef50_B7AQ13 Putative uncharacterized protein n=3 Tax=Bacteri... 304 2e-81 UniRef50_D1BP88 Tetrahydrofolate dehydrogenase/cyclohydrolase n=... 304 2e-81 UniRef50_A9UXQ1 Predicted protein n=7 Tax=cellular organisms Rep... 303 5e-81 UniRef50_C8WXG8 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 302 1e-80 UniRef50_B5YA73 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 302 1e-80 UniRef50_C8WAB5 Tetrahydrofolate dehydrogenase/cyclohydrolase n=... 301 2e-80 UniRef50_C6CV64 Methylenetetrahydrofolate dehydrogenase (NADP(+)... 300 3e-80 UniRef50_Q0SFQ8 Methenyltetrahydrofolate cyclohydrolase n=11 Tax... 300 3e-80 UniRef50_C2L112 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 300 4e-80 UniRef50_UPI00006CCCC6 methylenetetrahydrofolate dehydrogenase n... 299 5e-80 UniRef50_B2KB67 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 299 7e-80 UniRef50_D1ITY4 Whole genome shotgun sequence of line PN40024, s... 298 2e-79 UniRef50_B9K850 Bifunctional protein folD n=1 Tax=Thermotoga nea... 296 5e-79 UniRef50_A0DMT9 Chromosome undetermined scaffold_57, whole genom... 294 2e-78 UniRef50_A5ILJ9 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=... 294 2e-78 UniRef50_D2W298 Predicted protein n=2 Tax=Naegleria gruberi RepI... 293 5e-78 UniRef50_B5IEC2 Tetrahydrofolate dehydrogenase/cyclohydrolase, N... 291 2e-77 UniRef50_B7QFP4 C1-tetrahydrofolate synthase, putative n=1 Tax=I... 291 2e-77 UniRef50_C1BVL5 Bifunctional methylenetetrahydrofolate dehydroge... 290 3e-77 UniRef50_Q54VK0 Methenyl tetrahydrofolate cyclohydrolase / NADP-... 290 3e-77 UniRef50_Q0AWX5 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 290 3e-77 UniRef50_A0C3Q0 Chromosome undetermined scaffold_147, whole geno... 289 1e-76 UniRef50_A4X776 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=... 287 4e-76 UniRef50_B9CK25 Bifunctional protein FolD n=1 Tax=Atopobium rima... 284 2e-75 UniRef50_Q86F84 Clone ZZD1003 mRNA sequence n=2 Tax=Schistosoma ... 284 2e-75 UniRef50_C1MLD7 5,10-methylene-tetrahydrofolate dehydrogenase/cy... 282 8e-75 UniRef50_C8WN84 Tetrahydrofolate dehydrogenase/cyclohydrolase n=... 282 9e-75 UniRef50_Q04FB7 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=... 280 3e-74 UniRef50_UPI00003C8447 methylenetetrahydrofolate dehydrogenase/m... 279 7e-74 UniRef50_Q2JCX4 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=... 279 8e-74 UniRef50_Q1AVQ0 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 278 1e-73 UniRef50_C8WUM8 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 278 1e-73 UniRef50_C4QA37 Formate-tetrahydrofolate ligase, putative n=1 Ta... 277 3e-73 UniRef50_B5Y9D1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 277 3e-73 UniRef50_Q6L046 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 275 9e-73 UniRef50_Q160C0 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=... 275 1e-72 UniRef50_C5CI88 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 275 2e-72 UniRef50_Q979W3 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 272 1e-71 UniRef50_UPI00006CB712 tetrahydrofolate dehydrogenase/cyclohydro... 270 3e-71 UniRef50_Q4A6B1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 270 3e-71 UniRef50_B5RQK8 Methylenetetrahydrofolate dehydrogenase n=2 Tax=... 270 4e-71 UniRef50_Q4RT28 Chromosome 12 SCAF14999, whole genome shotgun se... 269 8e-71 UniRef50_D1VQM8 Methylenetetrahydrofolate dehydrogenase (NADP(+)... 267 3e-70 UniRef50_C4XED5 Putative uncharacterized protein n=1 Tax=Mycopla... 266 5e-70 UniRef50_Q4DH06 Methylenetetrahydrofolate dehydrogenase-like pro... 266 6e-70 UniRef50_Q8EV80 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 266 7e-70 UniRef50_B9KZ23 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 265 1e-69 UniRef50_A7HMQ2 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 262 1e-68 UniRef50_B7J0W5 Methenyltetrahydrofolate cyclohydrolase n=22 Tax... 260 3e-68 UniRef50_A6LP88 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 259 6e-68 UniRef50_A5IXS7 FolD bifunctional protein(Methylenetetrahydrofol... 259 9e-68 UniRef50_Q1J118 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=... 256 6e-67 UniRef50_D1B5M7 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 256 8e-67 UniRef50_D1VRZ1 Bifunctional protein FolD n=1 Tax=Peptoniphilus ... 255 2e-66 UniRef50_A7AXK7 Putative uncharacterized protein n=1 Tax=Ruminoc... 253 6e-66 UniRef50_UPI00003BDED9 hypothetical protein DEHA0E19294g n=2 Tax... 252 2e-65 UniRef50_D1J7X9 Methylenetetrahydrofolate dehydrogenase n=1 Tax=... 250 4e-65 UniRef50_Q6KID0 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 247 4e-64 UniRef50_B3PMJ8 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 246 7e-64 UniRef50_Q5IWX9 Plastid 5,10-methylene-tetrahydrofolate dehydrog... 245 2e-63 UniRef50_B8ZZU9 Putative uncharacterized protein MTHFD2 n=2 Tax=... 243 5e-63 UniRef50_A9BIV9 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=... 239 1e-61 UniRef50_P47259 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 233 6e-60 UniRef50_Q0AZF5 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 232 1e-59 UniRef50_A1RQQ5 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=... 227 3e-58 UniRef50_Q98QV3 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 226 8e-58 UniRef50_UPI000194D930 PREDICTED: methylene tetrahydrofolate deh... 225 2e-57 UniRef50_UPI00016B2244 FolD bifunctional protein n=2 Tax=candida... 223 4e-57 UniRef50_A8IQS8 Methylenetetrahydrofolate dehydrogenase/ methyle... 222 1e-56 UniRef50_C7GZF5 FolD protein n=1 Tax=Eubacterium saphenum ATCC 4... 219 9e-56 UniRef50_UPI0001B58450 methylenetetrahydrofolate dehydrogenase/m... 211 2e-53 UniRef50_B0RZW6 Methylenetetrahydrofolate dehydrogenase n=2 Tax=... 210 4e-53 UniRef50_B3QMF3 Tetrahydrofolate dehydrogenase/cyclohydrolase n=... 205 1e-51 UniRef50_Q9XYB0 PugilistDominant (Fragment) n=2 Tax=Eukaryota Re... 201 2e-50 UniRef50_Q7NAE4 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 200 7e-50 UniRef50_A9EVL6 Methylenetetrahydrofolate dehydrogenase (NAD(+))... 198 1e-49 UniRef50_D1Z754 Whole genome shotgun sequence assembly, scaffold... 198 3e-49 UniRef50_Q02046 Methylenetetrahydrofolate dehydrogenase [NAD+] n... 196 8e-49 UniRef50_C7HUG7 Bifunctional protein FolD protein n=1 Tax=Anaero... 191 3e-47 UniRef50_B8BYF8 Predicted protein n=1 Tax=Thalassiosira pseudona... 190 5e-47 UniRef50_C4QVL0 NAD-dependent 5,10-methylenetetrahydrafolate deh... 189 1e-46 UniRef50_B0CXH2 Predicted protein n=1 Tax=Laccaria bicolor S238N... 187 4e-46 UniRef50_Q4PBA5 Putative uncharacterized protein n=3 Tax=Basidio... 185 1e-45 UniRef50_Q4S6Y9 Chromosome 14 SCAF14723, whole genome shotgun se... 183 8e-45 UniRef50_C7RD94 Tetrahydrofolate dehydrogenase/cyclohydrolase n=... 179 9e-44 UniRef50_Q6UB35 Monofunctional C1-tetrahydrofolate synthase, mit... 177 3e-43 UniRef50_Q86KU6 Methylenetetrahydrofolate dehydrogenase [NAD+] n... 176 6e-43 UniRef50_Q5KEZ0 Methylenetetrahydrofolate dehydrogenase (NAD+), ... 173 8e-42 UniRef50_B1AIX6 Methylenetetrahydrofolate dehydrogenase n=15 Tax... 169 8e-41 UniRef50_B8NT34 Methylenetetrahydrofolate dehydrogenase, putativ... 169 8e-41 UniRef50_Q0UVW9 Putative uncharacterized protein n=1 Tax=Phaeosp... 169 1e-40 UniRef50_A6QZK7 Putative uncharacterized protein n=1 Tax=Ajellom... 165 2e-39 UniRef50_B5GAQ6 Tetrahydrofolate dehydrogenase/cyclohydrolase n=... 160 4e-38 UniRef50_UPI000023D48A hypothetical protein FG10624.1 n=1 Tax=Gi... 157 5e-37 UniRef50_B6WAQ3 Putative uncharacterized protein n=1 Tax=Anaeroc... 153 9e-36 UniRef50_A8ZN24 Putative uncharacterized protein n=1 Tax=Acaryoc... 143 7e-33 UniRef50_A6BAZ7 Fold bifunctional protein (Ppdc) (Fragment) n=1 ... 141 4e-32 UniRef50_Q5PNN5 Novel protein similar to methylenetetrahydrofola... 136 8e-31 UniRef50_UPI0000D9A063 PREDICTED: similar to Bifunctional methyl... 136 1e-30 UniRef50_B4FJK4 Putative uncharacterized protein n=1 Tax=Zea may... 127 3e-28 UniRef50_A4HZR2 Methylenetetrahydrofolate dehydrogenase-like pro... 124 5e-27 UniRef50_C0Z3J6 AT2G38660 protein n=2 Tax=Arabidopsis thaliana R... 119 1e-25 UniRef50_UPI00005A5066 PREDICTED: similar to Bifunctional methyl... 117 6e-25 UniRef50_UPI0001904966 Methenyltetrahydrofolate cyclohydrolase n... 115 2e-24 UniRef50_B6FPJ6 Putative uncharacterized protein n=1 Tax=Clostri... 111 3e-23 UniRef50_B9PLA1 Methylenetetrahydrofolate dehydrogenase, putativ... 109 1e-22 UniRef50_A1ZUI3 Tetrahydrofolate dehydrogenase/cyclohydrolase, N... 101 4e-20 UniRef50_Q6X5D4 Methylene-THF dehydrogenase (Fragment) n=1 Tax=T... 96 1e-18 UniRef50_B3L796 Putative uncharacterized protein n=2 Tax=Plasmod... 53 1e-05 Sequences not found previously or not previously below threshold: UniRef50_B7G8Y9 Predicted protein (Fragment) n=8 Tax=Eukaryota R... 155 1e-36 UniRef50_D0NPK1 Methylenetetrahydrofolate dehydrogenase [NAD+], ... 150 5e-35 UniRef50_B5Y3N3 Predicted protein n=1 Tax=Phaeodactylum tricornu... 127 5e-28 UniRef50_B8BT80 Methylenetetrahydrofolate dehydrogenase (Fragmen... 123 7e-27 UniRef50_Q3M1J6 Tetrahydrofolate dehydrogenase/cyclohydrolase n=... 119 2e-25 UniRef50_D0NV87 Tetrahydrofolate dehydrogenase n=7 Tax=Phytophth... 68 3e-10 UniRef50_UPI00015563B5 PREDICTED: similar to Mthfd2-prov protein... 68 3e-10 UniRef50_D0NYB3 Tetrahydrofolate dehydrogenase n=1 Tax=Phytophth... 67 6e-10 UniRef50_C6KTE2 Putative uncharacterized protein n=1 Tax=Plasmod... 52 3e-05 UniRef50_D0YQ76 Bifunctional protein FolD 2 (Fragment) n=2 Tax=c... 51 4e-05 UniRef50_Q0IEF9 Putative uncharacterized protein n=1 Tax=Aedes a... 48 3e-04 UniRef50_C7YLA7 Predicted protein n=1 Tax=Nectria haematococca m... 48 3e-04 UniRef50_Q4YPQ5 Putative uncharacterized protein n=4 Tax=Plasmod... 48 4e-04 UniRef50_A4YD89 Glutamyl-tRNA reductase n=1 Tax=Metallosphaera s... 46 0.001 UniRef50_A5MC89 Putative uncharacterized protein n=1 Tax=Strepto... 46 0.001 UniRef50_A4FH75 Ornithine/acetylornithine aminotransferase n=6 T... 45 0.003 UniRef50_C3YVA9 Putative uncharacterized protein n=1 Tax=Branchi... 44 0.004 UniRef50_C3Y6A1 Putative uncharacterized protein n=1 Tax=Branchi... 44 0.005 UniRef50_C6P544 Biotin/acetyl-CoA-carboxylase ligase n=1 Tax=Sid... 44 0.007 UniRef50_A8L9A5 S-adenosyl-L-homocysteine hydrolase n=1 Tax=Fran... 44 0.007 UniRef50_C1XXU4 Predicted dehydrogenase n=1 Tax=Meiothermus silv... 43 0.010 UniRef50_B7PXT3 Putative uncharacterized protein n=1 Tax=Ixodes ... 42 0.026 UniRef50_B5Y9H6 Shikimate / quinate 5-dehydrogenase domain prote... 42 0.026 UniRef50_B0PHV3 Putative uncharacterized protein n=2 Tax=Bacteri... 41 0.049 UniRef50_O29376 S-adenosylhomocysteinase hydrolase (AhcY-1) n=1 ... 41 0.052 UniRef50_A0M2A6 Alanine dehydrogenase n=19 Tax=Bacteroidetes Rep... 41 0.056 UniRef50_B4RWI6 S-adenosyl-L-homocysteine hydrolase n=3 Tax=Gamm... 41 0.062 UniRef50_B1Z0C8 Short-chain dehydrogenase/reductase SDR n=4 Tax=... 41 0.064 UniRef50_C8W3U8 Shikimate/quinate 5-dehydrogenase n=1 Tax=Desulf... 41 0.069 UniRef50_B8I2R3 Dipicolinate synthase subunit A n=5 Tax=Clostrid... 40 0.079 UniRef50_B1I1H2 Shikimate/quinate 5-dehydrogenase n=22 Tax=Clost... 40 0.084 UniRef50_Q4JAZ7 Adenosylhomocysteinase n=9 Tax=Archaea RepID=SAH... 40 0.099 >UniRef50_A0LE04 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Proteobacteria RepID=FOLD_MAGSM Length = 285 Score = 409 bits (1053), Expect = e-113, Method: Composition-based stats. Identities = 151/283 (53%), Positives = 198/283 (69%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A +IDGK IAQ VR E+ +V+ PGLAVVLVG++PASQ+YV +K++ACE Sbjct: 1 MAHVIDGKAIAQSVREELRMEVERLKLNHQLTPGLAVVLVGADPASQVYVRNKKRACETA 60 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S S++L TTS+AELL LI+ LN D+ + GILVQLPLP ID KVLE I P KD D Sbjct: 61 GIASFSHELAATTSQAELLALIEQLNQDDAVHGILVQLPLPKHIDEQKVLEAISPSKDAD 120 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GFHPYNVGRL P +PCTP G++ +L+ +D G +AVVIG SNIVG+P+++ LL Sbjct: 121 GFHPYNVGRLVTGDPTFQPCTPWGVMEMLKVSGVDPKGKHAVVIGRSNIVGKPVALMLLA 180 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 A T T+ H T +L V+ AD+++ AVG+ +PG WIK+GA+VIDVGINR E+GK+ Sbjct: 181 AHATVTICHSRTPDLAETVKRADIVVAAVGRANMVPGSWIKKGAVVIDVGINRGEDGKLC 240 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 GDV + + AS ITPVPGGVGPMT+A L++NT++ H+ Sbjct: 241 GDVDYASCFEHASAITPVPGGVGPMTIAMLLKNTVEGAKRAHN 283 >UniRef50_A7MT09 Methenyltetrahydrofolate cyclohydrolase n=64 Tax=cellular organisms RepID=FOLD_VIBHB Length = 286 Score = 407 bits (1046), Expect = e-112, Method: Composition-based stats. Identities = 208/286 (72%), Positives = 246/286 (86%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A+ IDG I+Q VRSEVA +V+AR+ AGLRAPGLAVVLVG +PASQ+YV SKR+ACEE Sbjct: 1 MTAQNIDGTLISQTVRSEVAARVKARVEAGLRAPGLAVVLVGEDPASQVYVGSKRRACEE 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VGFVS+S+DLP TTSE ELL LID LN D IDGILVQLPLPAGID VLERIHP+KDV Sbjct: 61 VGFVSKSFDLPATTSEEELLALIDELNNDAEIDGILVQLPLPAGIDATHVLERIHPEKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHPYNVGRL QR P+LR CTP+GI+TLL+RYNI+ G +AVV+GASNIVGRPM++ELL Sbjct: 121 DGFHPYNVGRLAQRIPKLRSCTPKGIITLLDRYNIELRGKHAVVVGASNIVGRPMTLELL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 LAGCTTT HRFTK+L HV ADL++VAVGKP FIPG+WIK+GA+V+DVGINRLE+GK+ Sbjct: 181 LAGCTTTTCHRFTKDLEGHVRQADLVVVAVGKPNFIPGEWIKKGAVVVDVGINRLESGKL 240 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 VGDV ++ A + AS+ITPVPGGVGPMTVA+LIENT+ AC ++H + Sbjct: 241 VGDVEYDKARENASFITPVPGGVGPMTVASLIENTMLACEQFHTKK 286 >UniRef50_A5F6V4 Methenyltetrahydrofolate cyclohydrolase n=270 Tax=Bacteria RepID=FOLD_VIBC3 Length = 286 Score = 403 bits (1037), Expect = e-111, Method: Composition-based stats. Identities = 202/283 (71%), Positives = 240/283 (84%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A+ IDG I+Q VRSEVA +V+AR+ AGLRAPGLAVVLVG +PASQ+YV SKR+ACEE Sbjct: 1 MTAQNIDGTLISQTVRSEVAARVKARVQAGLRAPGLAVVLVGEDPASQVYVGSKRRACEE 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VGFVS+S+DLP T SE LL L++ LN D IDGILVQLPLPAG+D KVLE IHP+KDV Sbjct: 61 VGFVSKSFDLPATASEEALLSLVEELNNDPQIDGILVQLPLPAGMDTTKVLESIHPEKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHPYNVGRL QR P+LR CTP+GI+TLLERYNI G +AV++GASNIVGRPM++ELL Sbjct: 121 DGFHPYNVGRLAQRIPKLRSCTPKGIITLLERYNIPLRGKHAVIVGASNIVGRPMTLELL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 LAGCTTT HRFT++L H+ AD+L+VAVGKP FIPG WIKEGA+V+DVGINRL+ GK+ Sbjct: 181 LAGCTTTTCHRFTQDLEGHIRQADILVVAVGKPNFIPGAWIKEGAVVVDVGINRLDTGKL 240 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 VGDV ++ A RAS+ITPVPGGVGPMTVA+LIENT+ AC ++H Sbjct: 241 VGDVEYDVARTRASFITPVPGGVGPMTVASLIENTMMACEQFH 283 >UniRef50_Q0AB42 Methenyltetrahydrofolate cyclohydrolase n=19 Tax=cellular organisms RepID=FOLD_ALHEH Length = 286 Score = 403 bits (1036), Expect = e-111, Method: Composition-based stats. Identities = 169/280 (60%), Positives = 215/280 (76%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M+A+I+DGK IA ++R +V ++V+AR+ G R PGLAVVLVG++PAS +YV KR+ACE+ Sbjct: 1 MSAQILDGKAIAAELREQVRKQVEARVERGGRRPGLAVVLVGADPASTVYVGKKRQACEQ 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G S +++LP T++ ELL L+D LN + IDGILVQLPLP ID V++RIHPDKDV Sbjct: 61 LGMHSSAHELPAETTQDELLALVDELNGRDEIDGILVQLPLPDHIDEQTVIDRIHPDKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP N+GRL R P LRPCTP G++T+L I+ G +AV+IG SNIVGRPM+MELL Sbjct: 121 DGFHPVNMGRLTLRLPGLRPCTPNGVMTMLAHAGIELEGKDAVIIGQSNIVGRPMAMELL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 A CT T+ H T+NL V AD+++ AVG+PGF+PGDWIK GA+VIDVGINRLE+GK+ Sbjct: 181 NARCTITICHSRTRNLADRVRAADIVVAAVGRPGFVPGDWIKPGAVVIDVGINRLESGKL 240 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 GDV F A + A +ITPVPGGVGPMTVATL+ NTL A Sbjct: 241 TGDVDFAAARELAGWITPVPGGVGPMTVATLMANTLAAAE 280 >UniRef50_O65271 F6N23.26 protein n=34 Tax=Viridiplantae RepID=O65271_ARATH Length = 360 Score = 391 bits (1006), Expect = e-107, Method: Composition-based stats. Identities = 136/292 (46%), Positives = 185/292 (63%), Gaps = 8/292 (2%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A +IDGK +A+++R E+ +V + PGLAV+LVG S YV +K+KAC+ VG Sbjct: 69 AIVIDGKAVAKKIRDEITIEVSRMKESIGVIPGLAVILVGDRKDSATYVRNKKKACDSVG 128 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 S L E +SE E+L+ + N D ++ GILVQLPLP+ +D +L + +KDVDG Sbjct: 129 IKSFEVRLAEDSSEEEVLKSVSGFNDDPSVHGILVQLPLPSHMDEQNILNAVSIEKDVDG 188 Query: 123 FHPYNVGRLCQ--RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 FHP N+GRL R P PCTP+G + LL RYNI+ G AVVIG SNIVG P ++ L Sbjct: 189 FHPLNIGRLAMRGREPLFVPCTPKGCIELLHRYNIEIKGKRAVVIGRSNIVGMPAALLLQ 248 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-- 238 T ++ H TKN AD++I AVG+P + G WIK GA++IDVGIN +E+ Sbjct: 249 REDATVSIIHSRTKNPEEITREADIIISAVGQPNMVRGSWIKPGAVLIDVGINPVEDPSA 308 Query: 239 ----KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 ++VGD+ +E+A+K AS ITPVPGGVGPMT+A L+ NTL + H+ Q Sbjct: 309 ARGYRLVGDICYEEASKVASAITPVPGGVGPMTIAMLLSNTLTSAKRIHNFQ 360 >UniRef50_A3DEE6 Methenyltetrahydrofolate cyclohydrolase n=6 Tax=Bacteria RepID=FOLD_CLOTH Length = 285 Score = 390 bits (1003), Expect = e-107, Method: Composition-based stats. Identities = 147/280 (52%), Positives = 196/280 (70%), Gaps = 1/280 (0%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M AK+++GK ++ +++ E+ +V+ + PGLAV++VG++PAS++YV SK+KAC E Sbjct: 1 MEAKVLNGKELSTKIKEELKIEVEDLKKNNIN-PGLAVIIVGNDPASRVYVNSKKKACAE 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G S Y L E T++ EL+ELI LN D+ + GILVQLPLP ID KV+ I P KDV Sbjct: 60 IGIESFEYALEENTTQEELIELIHKLNKDDKVSGILVQLPLPKHIDEEKVIYAIDPSKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 D FHP NVG+L P PCTP G++ L++ ID G VV+G SNIVG+PM+M LL Sbjct: 120 DAFHPVNVGKLMIGNPDFLPCTPAGVMELIKESGIDITGKECVVVGRSNIVGKPMAMLLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T TV H T+N+ + AD+L+VAVGKP FI G IK GA+VIDVGINRLEN K+ Sbjct: 180 AQNGTVTVCHSRTQNIDEVCKRADILVVAVGKPEFIKGSSIKPGAVVIDVGINRLENKKL 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 VGDV +E A++ AS ITPVPGGVGPMT+A L++NT++A Sbjct: 240 VGDVEYESASRVASAITPVPGGVGPMTIAMLMKNTVKAAK 279 >UniRef50_Q82XC3 Methenyltetrahydrofolate cyclohydrolase n=7 Tax=Proteobacteria RepID=FOLD_NITEU Length = 295 Score = 384 bits (988), Expect = e-105, Method: Composition-based stats. Identities = 134/281 (47%), Positives = 177/281 (62%), Gaps = 1/281 (0%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M+A II G IA + R E+ Q+V+ + PGLAV+L G NPAS +YV +K K CEE Sbjct: 1 MSATIISGSLIASKFREELKQRVKIL-SETWMQPGLAVILAGDNPASCVYVRNKAKTCEE 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G S ++ P S+ LL+ I LN + I GILVQLPLP I +V+ I KDV Sbjct: 60 LGIRSEIFNFPGDISQKALLQQIQDLNVNPEIHGILVQLPLPGHIRIDEVIAAIAIGKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP NVG L PCTP G++ +L Y+I G +AV+IG SNIVG+PM++ LL Sbjct: 120 DGFHPCNVGALVTGHALFHPCTPFGVMKMLAEYDIPLQGQHAVIIGRSNIVGKPMALMLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 G T TV T++L H NAD++++A GK + D I+ GA VIDVGINRL +G++ Sbjct: 180 EKGATVTVCTSRTRDLASHTRNADIVVMAAGKANLLTSDMIRTGATVIDVGINRLADGRL 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 GDV F ++A YITPVPGGVGPMT+ L+ NT++A Sbjct: 240 CGDVEFSGVKEKAGYITPVPGGVGPMTIVMLMNNTIEAAER 280 >UniRef50_B5YJV1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=FOLD_THEYD Length = 286 Score = 377 bits (970), Expect = e-103, Method: Composition-based stats. Identities = 142/280 (50%), Positives = 197/280 (70%), Gaps = 1/280 (0%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M+A+I+DGK++A +++ E+ ++VQ G+ P LAVVLVG N +SQ YV+ K K C+E Sbjct: 1 MSAEILDGKSLALKIKEELKKEVQDLKNQGIN-PCLAVVLVGENKSSQKYVSFKEKTCKE 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 + S + LPE T E L++LID LN ++ ++GIL+QLPLP ++ KVLERI+P KDV Sbjct: 60 LDIQSLVFKLPENTEETSLIKLIDELNENSQVNGILIQLPLPKHLNQNKVLERINPFKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGF P+ +GRL +P PCTP+GI+ +L+ Y I+ G AVVIG S IVG+P+S+ LL Sbjct: 120 DGFTPFCLGRLLIDSPLFIPCTPKGIIRMLDEYKINLEGKQAVVIGRSIIVGKPLSLLLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T T+ H T NL+ + AD+L VA+G+ FI + IK+GA+VID+GIN +GKV Sbjct: 180 KRNATVTMCHSKTINLQDITKKADILCVAIGREKFITSNMIKKGAVVIDIGINVTASGKV 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 VGDV F+D ++ASYITPVPGGVGPMT+A L+EN + A Sbjct: 240 VGDVNFDDVKEKASYITPVPGGVGPMTIAMLMENAIYAAK 279 >UniRef50_Q2JQ25 Methenyltetrahydrofolate cyclohydrolase n=8 Tax=cellular organisms RepID=FOLD_SYNJB Length = 293 Score = 374 bits (962), Expect = e-102, Method: Composition-based stats. Identities = 140/288 (48%), Positives = 184/288 (63%), Gaps = 4/288 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M AKI+DGK +A ++++E+A +VQA I R PGLAV+ VG +PAS YV K +ACE Sbjct: 1 MPAKILDGKALAARLQAEMAAQVQAWIPQVGRPPGLAVLRVGEDPASAAYVRGKERACER 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G S S A LL+ ID LN D +DGILVQLPLP G D + L I+PDKDV Sbjct: 61 LGIASFGRHFSAQDSPAHLLDTIDQLNQDERVDGILVQLPLPPGWDPIPPLLAINPDKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG HP N+GRL + P LR CTP G++ LL+ I G AVV+G S +VG+P+S+ LL Sbjct: 121 DGLHPLNLGRLLRGEPGLRSCTPLGVMRLLQAEGIPIAGRKAVVVGRSILVGKPLSLMLL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-- 238 A T T+ H T +L AD++++AVG+P + D +K GA+VIDVGINR+E Sbjct: 181 AADATVTLAHSRTPDLAEVTRAADIVVMAVGRPRLLRADMVKPGAVVIDVGINRIETPTG 240 Query: 239 --KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 ++VGDV +E + A+ ITPVPGGVGPMTV L+ NTLQ+ Sbjct: 241 AEQLVGDVDYEAVKELAAAITPVPGGVGPMTVTMLLANTLQSYKLRSH 288 >UniRef50_B8HXS0 Methenyltetrahydrofolate cyclohydrolase n=25 Tax=cellular organisms RepID=FOLD_CYAP4 Length = 293 Score = 372 bits (957), Expect = e-102, Method: Composition-based stats. Identities = 138/284 (48%), Positives = 189/284 (66%), Gaps = 4/284 (1%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 ++DGK +AQ++++++ +VQA R PGLAV++VG NPAS YV +K +ACE+VG Sbjct: 7 NLLDGKALAQEMQADLTLQVQALQTRVGRPPGLAVLMVGDNPASAAYVRNKERACEQVGI 66 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S + LP T++AELL LI+ LN D +DGILVQLPLP +D +L I P KD DG Sbjct: 67 ASFGHHLPTETTQAELLTLINQLNQDPRVDGILVQLPLPNHLDARALLYAIDPTKDADGL 126 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 HP N+GRL + P LR CTP G++ LL++YNI+ G AVVIG S +VG+P++M LL A Sbjct: 127 HPENLGRLVRSEPGLRSCTPAGVMRLLQKYNIELRGKEAVVIGRSILVGKPLAMMLLEAD 186 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL----ENGK 239 T T+ H + +L AD+LI AVGKPG + +K GA+V+DVGINR+ + Sbjct: 187 ATVTIAHSRSTDLAEIARRADILIAAVGKPGLVSAGMVKAGAVVVDVGINRVVEATGKSR 246 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 +VGDV F A YITPVPGG+GPMTVA L++NT+ + + + Sbjct: 247 LVGDVDFAAVQPIAGYITPVPGGIGPMTVAMLLDNTVCSFQQRN 290 >UniRef50_A8JH65 5,10-methylenetetrahydrofolate dehydrogenase n=4 Tax=cellular organisms RepID=A8JH65_CHLRE Length = 340 Score = 371 bits (953), Expect = e-101, Method: Composition-based stats. Identities = 143/288 (49%), Positives = 181/288 (62%), Gaps = 8/288 (2%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A+K+IDGK IA +RSE+A +V PGLAVVLVG+ S+ YV SK+KAC EV Sbjct: 44 ASKLIDGKGIADTIRSEIATEVADMKKQYGLTPGLAVVLVGARKDSETYVRSKKKACAEV 103 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 GF S DLP SE ELL+++ NAD + GILVQLPLP I ++L+ I DKDVD Sbjct: 104 GFDSFGTDLPADVSEEELLKVVAAYNADPRVHGILVQLPLPKHISEKRILDAISIDKDVD 163 Query: 122 GFHPYNVGRLCQ--RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 GFHP N+G L R P PCTP+G + LLER + G A VIG SNIVG P ++ L Sbjct: 164 GFHPLNIGCLAMRGRDPLFVPCTPKGCIELLERMKVPIAGKKACVIGRSNIVGMPAALLL 223 Query: 180 LLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG- 238 T T+ H T + + AD++I A G + GDWIK GA+VIDVGIN ++ Sbjct: 224 QRRDATVTMVHSKTPDAKKICSEADIVIAACGVAEMVTGDWIKPGAVVIDVGINAKDDAT 283 Query: 239 -----KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 ++VGDV FE AA +AS ITPVPGGVGPMT+A L++NTL++ Sbjct: 284 QKKGYRLVGDVEFEGAAAKASLITPVPGGVGPMTIAMLLQNTLESARR 331 >UniRef50_Q46A53 Methenyltetrahydrofolate cyclohydrolase n=13 Tax=cellular organisms RepID=FOLD_METBF Length = 287 Score = 370 bits (950), Expect = e-101, Method: Composition-based stats. Identities = 129/279 (46%), Positives = 184/279 (65%), Gaps = 1/279 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 ++IIDGK +A+++ EV V+A ++ PGLA VLVG +PAS++YV K +ACE V Sbjct: 7 ESRIIDGKVLAKKIEDEVRSGVEALVSGRGITPGLATVLVGDDPASKMYVRLKHRACERV 66 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + + LP TS+ EL+ LI+TLN D + GIL+QLPLP + + +E I P+KD D Sbjct: 67 GIQAEDHFLPAETSQEELISLINTLNKDQNVHGILLQLPLPKHLFPQEAMEAIAPEKDAD 126 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GFHPYN+G+L L PCTP G++ LE YN+ G N V++G SN+VG+P++ L Sbjct: 127 GFHPYNMGKLMIGDEGLVPCTPHGVIRALEEYNVPVKGKNVVIVGHSNVVGKPLAAMFLN 186 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 T +V H FT +L+ + +AD+L+VA G I D +KEGA++ DVGI + ++G V Sbjct: 187 RNATVSVCHVFTDDLKKYTLDADILVVATGVKHLIKADMVKEGAVIFDVGITKEKDG-VY 245 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 GDV FE+ K+A+ ITPVPGGVGP+TVA L+++ L Sbjct: 246 GDVDFENVIKKAALITPVPGGVGPLTVAMLMKHVLGCAE 284 >UniRef50_C4FUB1 Putative uncharacterized protein n=1 Tax=Catonella morbi ATCC 51271 RepID=C4FUB1_9FIRM Length = 294 Score = 367 bits (943), Expect = e-100, Method: Composition-based stats. Identities = 129/279 (46%), Positives = 174/279 (62%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 +DGKT++Q + + ++Q A + P L V+ VG +PAS++YV K+K E+G+ Sbjct: 4 LDGKTLSQSIFARLSQATAAFRSQTGTQPKLTVISVGEDPASKVYVGQKQKRALEIGYAF 63 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 LP S+ EL I N D G+L+QLPLP +D + + I P+KDVDGFHP Sbjct: 64 EWMLLPADISQEELERTIKVHNQDPQTHGLLLQLPLPDHLDPLSAMHLIDPEKDVDGFHP 123 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCT 185 +GR+ + L PCTP+GIV LLE I G N VV+G S IVG P+S+ L+ G T Sbjct: 124 LTMGRVVEDNTDLYPCTPKGIVRLLENAQIPLQGQNVVVVGRSQIVGLPISIMLINRGAT 183 Query: 186 TTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVV 245 TV + T++L H+ AD+LIVA G+ I D +KEGA+V+DVGINRL +GK+VGDV Sbjct: 184 VTVCNSKTQDLGHYTRYADILIVATGQAHLIGPDHLKEGAVVVDVGINRLMSGKLVGDVD 243 Query: 246 FEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 FE A + SYITPVPGGVGPMTVA L+E T + + Sbjct: 244 FEAVAHKVSYITPVPGGVGPMTVAMLMEQTFTCACQQQN 282 >UniRef50_A4XY05 Methenyltetrahydrofolate cyclohydrolase n=47 Tax=Proteobacteria RepID=FOLD3_PSEMY Length = 307 Score = 367 bits (942), Expect = e-100, Method: Composition-based stats. Identities = 148/280 (52%), Positives = 188/280 (67%), Gaps = 4/280 (1%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 K+IDGK A +V +EVA+ V+A AAG+ P LAVVLVG +PASQ+YV +K EE G Sbjct: 8 KLIDGKAAAARVLAEVAEDVRALKAAGI-VPALAVVLVGDDPASQVYVRNKVLRAEECGI 66 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S + LP T+EA L LI LNAD ++ GILVQLPLPA ID +VL+ + P KDVDGF Sbjct: 67 RSLEFKLPADTAEARLQALIAELNADASVHGILVQLPLPAHIDEQRVLQAVTPLKDVDGF 126 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 H NVG L Q L PCTP G + LL+ D G +AVVIG SNIVG+PM+ LL A Sbjct: 127 HAENVGGLSQGREVLTPCTPAGCLRLLQDSCGDLTGKHAVVIGRSNIVGKPMAALLLKAH 186 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG---KV 240 C+ TV H + NL+ AD+++ AVG+P + DW+K GA+VIDVGINR++ ++ Sbjct: 187 CSVTVVHSKSANLKTLCRQADIVVAAVGRPRLVDADWLKPGAVVIDVGINRIDENGRSRL 246 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 VGDV F+ A + S ITPVPGGVGPMT+A L++NTL A Sbjct: 247 VGDVDFDSALPQVSAITPVPGGVGPMTIAYLMKNTLVAAR 286 >UniRef50_B0KLM9 Methenyltetrahydrofolate cyclohydrolase n=184 Tax=Bacteria RepID=FOLD2_PSEPG Length = 303 Score = 366 bits (941), Expect = e-100, Method: Composition-based stats. Identities = 149/285 (52%), Positives = 188/285 (65%), Gaps = 8/285 (2%) Query: 1 MAA----KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRK 56 M A K+IDGK A +V +EV ++VQ G PGL VVLVG++ ASQ+YV +K Sbjct: 1 MNALTSLKLIDGKATAARVLAEVREQVQELR-QGGVQPGLVVVLVGADAASQVYVRNKVL 59 Query: 57 ACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHP 116 EEVG S+ + LP T++A LL LID LN D ++GILVQLPLPA ID VL+ I+P Sbjct: 60 RAEEVGIRSQEHRLPADTTQAHLLTLIDRLNRDPEVNGILVQLPLPAHIDEHCVLQAINP 119 Query: 117 DKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMS 176 KDVDGFH NVG L Q L PCTP G + LL + G +AVV+G SNIVG+PM+ Sbjct: 120 LKDVDGFHSENVGGLAQGRDVLTPCTPSGCMRLLRDACGELRGKHAVVVGRSNIVGKPMA 179 Query: 177 MELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL- 235 LL A CT TV H +++L AD+L+ AVGKP I D +K GA+VIDVGINR+ Sbjct: 180 ALLLQADCTVTVVHSRSRDLPALCRQADILVAAVGKPRLIGADCLKPGAVVIDVGINRIN 239 Query: 236 ENGK--VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 E+G+ +VGDV F A + + ITPVPGGVGPMT+A L++NTL A Sbjct: 240 EDGQNHLVGDVDFAAALPQVAGITPVPGGVGPMTIAYLMKNTLLA 284 >UniRef50_Q8LEA3 5,10-methylenetetrahydrofolate dehydrogenase:5,10-methenyltetrahydrofolate cyclohydrolase, putative n=9 Tax=Eukaryota RepID=Q8LEA3_ARATH Length = 299 Score = 366 bits (941), Expect = e-100, Method: Composition-based stats. Identities = 141/288 (48%), Positives = 181/288 (62%), Gaps = 8/288 (2%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 AKIIDGK IA +RSE+A++V+ + PGLAVV+VGS SQ YV +KRKAC EV Sbjct: 8 TAKIIDGKAIAHTIRSEIAEEVRGLSEKHGKVPGLAVVIVGSRKDSQTYVNTKRKACAEV 67 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S LPE SEA+L+ + LN++ + GILVQLPLP I+ +L I DKDVD Sbjct: 68 GIKSFDVGLPEEVSEADLISKVHELNSNPDVHGILVQLPLPKHINEENILGAISIDKDVD 127 Query: 122 GFHPYNVGRLCQR--APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 GFHP N+G+L + P PCTP+G + LL R + G AVV+G SNIVG P+S+ L Sbjct: 128 GFHPLNIGKLAMKGREPLFLPCTPKGCLELLARSGVKIKGQRAVVVGRSNIVGLPVSLLL 187 Query: 180 LLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG- 238 L A T T H TK+ + AD++I A G+ I G+WIK GA VIDVG N + + Sbjct: 188 LKADATVTTVHSHTKDPEAIIREADIVIAACGQAHMIKGNWIKPGAAVIDVGTNAVSDPS 247 Query: 239 -----KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 ++VGDV F +A+K A +ITPVPGGVGPMTVA L+ NT+ Sbjct: 248 KKSGYRLVGDVDFAEASKVAGFITPVPGGVGPMTVAMLLRNTVDGAKR 295 >UniRef50_B2V9R3 Methenyltetrahydrofolate cyclohydrolase n=14 Tax=Bacteria RepID=FOLD_SULSY Length = 285 Score = 366 bits (940), Expect = e-100, Method: Composition-based stats. Identities = 150/280 (53%), Positives = 199/280 (71%), Gaps = 3/280 (1%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 ++DGK++A+++++++ Q++ G R P L+V+LVG NPASQIYV K K C VG Sbjct: 3 LLDGKSLAEKIKNQIKQEIDQLTQKGYRQPVLSVILVGENPASQIYVNKKIKDCASVGIK 62 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S+ + LPE ++ ELLELI LN D +DGILVQLPLP+ I+ ++++E I+P KDVDGFH Sbjct: 63 SKPFFLPENITQTELLELIGDLNGDEEVDGILVQLPLPSHINTLEIIEAINPYKDVDGFH 122 Query: 125 PYNVGRLCQR-APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA- 182 P NVG+L + PCTP GI+ LL YNID FG + VV+GASNIVG+PMS+ L Sbjct: 123 PINVGKLATGRNDAILPCTPYGIMKLLHEYNIDHFGKDVVVVGASNIVGKPMSLLFLKDE 182 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T T+ H+ TK+L+ H AD+L+VAVGKP I D +KEGA+VIDVGINR+ +GK+VG Sbjct: 183 KSTVTICHKNTKDLKSHTLKADILVVAVGKPKLITEDMVKEGAVVIDVGINRV-DGKIVG 241 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 DV FE+ K+A ITPVPGGVGPMTVA L+ NTL+ Sbjct: 242 DVDFENVKKKAYAITPVPGGVGPMTVAMLLYNTLEIYKRK 281 >UniRef50_A0K8R4 Methenyltetrahydrofolate cyclohydrolase n=254 Tax=cellular organisms RepID=FOLD_BURCH Length = 285 Score = 365 bits (938), Expect = e-100, Method: Composition-based stats. Identities = 146/281 (51%), Positives = 189/281 (67%), Gaps = 1/281 (0%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A +IDG +++ +R++ A++ A A G + PGLAV+LVG+NPAS++YV +K KACE+ Sbjct: 1 MTALLIDGNALSKTLRAQAAERAAALTARGHQ-PGLAVILVGANPASEVYVRNKIKACED 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 GF S P T SEA+LL ID LN D I GILVQLPLPA ID+ KV+E I P+KDV Sbjct: 60 NGFFSLKDAYPATLSEADLLARIDELNRDPKIHGILVQLPLPAHIDSHKVIEAIAPEKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFH N G L P RPCTP G++ + E + I G NAVVIG SNIVG+PM+M LL Sbjct: 120 DGFHVANAGALMTGKPLFRPCTPYGVMKMFEAHGIALQGANAVVIGRSNIVGKPMAMMLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 AG T T+ H T++L H AD+++ AVGK + D +K GA VIDVG+NR + GK+ Sbjct: 180 DAGATVTICHSKTRDLAAHTREADIVVAAVGKRNILTADMVKPGATVIDVGMNRDDAGKL 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 GDV F + A YITPVPGGVGPMT+ L+ NT+++ Sbjct: 240 CGDVDFAGVKEVAGYITPVPGGVGPMTITMLLINTIESAER 280 >UniRef50_Q6GI21 Methenyltetrahydrofolate cyclohydrolase n=83 Tax=Bacteria RepID=FOLD_STAAR Length = 286 Score = 364 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 132/278 (47%), Positives = 189/278 (67%), Gaps = 1/278 (0%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M AKI+DGK IA+ R + +V+A G P L+V+LVG++ ASQ YV SK+KA E+ Sbjct: 1 MVAKILDGKQIAKDYRQGLQNQVEALKEKGF-TPKLSVILVGNDGASQSYVRSKKKAAEK 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G +S L ET +E E+L ++ LN D+++ GILVQ+PLP + K+LE I+PDKDV Sbjct: 60 IGMISEIVHLEETATEEEVLNELNRLNNDDSVSGILVQVPLPKQVSEQKILEAINPDKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP N+G+L PCTP GI+ +L+ +ID G NAVVIG S+IVG+P+S LL Sbjct: 120 DGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEGKNAVVIGRSHIVGQPVSKLLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 + T+ H +K++ ++++AD+++ AVGKPG + D +KEGA++IDVG ENGK+ Sbjct: 180 QKNASVTILHSRSKDMASYLKDADVIVSAVGKPGLVTKDVVKEGAVIIDVGNTPDENGKL 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 GDV ++ + A ITPVPGGVGP+T+ ++ NTL A Sbjct: 240 KGDVDYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLA 277 >UniRef50_Q12V26 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=cellular organisms RepID=FOLD_METBU Length = 286 Score = 363 bits (933), Expect = 3e-99, Method: Composition-based stats. Identities = 128/280 (45%), Positives = 183/280 (65%), Gaps = 1/280 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 KIIDG+ IA++V +EV V+ + PGL+ +LVG +PAS++YV K KAC V Sbjct: 6 NTKIIDGRAIAKKVEAEVKADVERLVREKGITPGLSAILVGEDPASKMYVRLKHKACGRV 65 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + LPE ++ ELLE I +LNA I GIL+QLPLP ++ + + I P KD D Sbjct: 66 GIFAEDQHLPEDITQEELLEAISSLNARKDIHGILLQLPLPKHLNEQEAMNAIDPAKDAD 125 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GFHP+N+G+L L PCTP+GI+ LE Y ++ G +AV++G SN+VG+PM+ L+ Sbjct: 126 GFHPFNMGQLLIGVEELVPCTPKGIIRALEEYGVEIQGKHAVIVGHSNVVGKPMAAMLVN 185 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 T ++ H FTK++ +AD+L+VA G I D +KEG+++ DVGI ENGKV Sbjct: 186 RNATVSICHVFTKDVTKFTRDADILVVATGVKHLIKEDMVKEGSVIFDVGITE-ENGKVY 244 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 GDV FE+ K+AS +TPVPGGVGP+T+ATL+++ L + + Sbjct: 245 GDVDFENVIKKASRVTPVPGGVGPVTIATLMQHVLMSAQK 284 >UniRef50_Q6F9E6 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Acinetobacter sp. ADP1 RepID=FOLD1_ACIAD Length = 297 Score = 362 bits (929), Expect = 1e-98, Method: Composition-based stats. Identities = 152/289 (52%), Positives = 185/289 (64%), Gaps = 6/289 (2%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 + KIIDGK IAQ V EV +V+ A G+ P LAVVLVG +PASQ+YV +K + V Sbjct: 10 SPKIIDGKAIAQSVLEEVKLEVERYKAQGIE-PCLAVVLVGEDPASQVYVRNKVQKAAFV 68 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S + SE ELL ID LN + + GILVQLPLP I+ +VLERIHP KDVD Sbjct: 69 GIRSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVD 128 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERY-NIDTFGLNAVVIGASNIVGRPMSMELL 180 GFH NVG L Q L PCTP G + LL+ D GL+AVVIG SNIVG+PM+ LL Sbjct: 129 GFHSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLL 188 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL---EN 237 CT TV H T+N+ + AD+++ AVGK I ++K A+VIDVGINR+ E Sbjct: 189 KESCTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGINRIMTHEK 248 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 ++VGDV FEDA S ITPVPGGVGPMT+A L++NTLQA V PQ Sbjct: 249 TRLVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQA-VRLQHPQ 296 >UniRef50_P13995 Methenyltetrahydrofolate cyclohydrolase n=52 Tax=cellular organisms RepID=MTDC_HUMAN Length = 350 Score = 362 bits (929), Expect = 1e-98, Method: Composition-based stats. Identities = 139/295 (47%), Positives = 185/295 (62%), Gaps = 15/295 (5%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A +I G+ +AQQ++ EV Q+V+ +A+G + P L+V+LVG NPAS YV +K +A V Sbjct: 36 EAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVV 95 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S + P + SE ELL LI+ LN D+ +DG+LVQLPLP ID ++ + PDKDVD Sbjct: 96 GINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVD 155 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GFH NVGR+C + P TP G+ +++R I T G N VV G S VG P++M L Sbjct: 156 GFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHT 215 Query: 182 AG--------CTTTVTHRFTK--NLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVG 231 G T T++HR+T L+ H AD++I A G P I D IKEGA VIDVG Sbjct: 216 DGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVG 275 Query: 232 INRLEN-----GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 INR+ + K+VGDV FE ++A YITPVPGGVGPMTVA L++NT+ A + Sbjct: 276 INRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKK 330 >UniRef50_A0M554 Methenyltetrahydrofolate cyclohydrolase n=88 Tax=Bacteria RepID=FOLD_GRAFK Length = 299 Score = 359 bits (922), Expect = 7e-98, Method: Composition-based stats. Identities = 144/289 (49%), Positives = 190/289 (65%), Gaps = 10/289 (3%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+DGK I+ ++ E+A +V G + P LA ++VG + AS YV SK KACE VGF Sbjct: 3 ILDGKKISNDIKDEIAGEVTKIKKRGEKVPHLAAIIVGKDGASMTYVNSKVKACERVGFE 62 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S + LP T SE ELL+ I+ LN ++ IDG +VQLPLP I+ KVL + PDKDVDGFH Sbjct: 63 SSLFRLPHTVSELELLDKIEELNENDDIDGFIVQLPLPPQINTQKVLNAVDPDKDVDGFH 122 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 P N G++ P TP GI+ LLERY+I T G + VVIG S IVGRPMS+ + +G Sbjct: 123 PTNFGKMALDMTSFIPATPFGILELLERYDIPTKGKHTVVIGRSYIVGRPMSILMGRSGF 182 Query: 185 ----TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGK- 239 T T+TH FTKN+ AD++I+AVG P F+ G+ IK+ A++IDVGI R+ + Sbjct: 183 PGNSTVTLTHEFTKNITQVTSQADIIIIAVGIPDFLKGEMIKDDAVIIDVGITRVPDDHA 242 Query: 240 -----VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 + GDV FE+ +KRAS+ITPVPGGVGPMTV+ L++NTL A +H Sbjct: 243 ERGYVIKGDVDFENVSKRASFITPVPGGVGPMTVSMLLKNTLLARERHH 291 >UniRef50_P11586 Formyltetrahydrofolate synthetase n=378 Tax=root RepID=C1TC_HUMAN Length = 935 Score = 359 bits (921), Expect = 9e-98, Method: Composition-based stats. Identities = 122/293 (41%), Positives = 179/293 (61%), Gaps = 11/293 (3%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAA-GLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A+I++GK I+ Q+R+ + +V P LA++ VG+ S +Y+ K KA EE+ Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPA--GIDNVKVLERIHPDKD 119 G + LP TT+E+E+++ I +LN D+T+ G LVQLPL + I+ +V+ I P+KD Sbjct: 64 GIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKD 123 Query: 120 VDGFHPYNVGRLCQR--APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSM 177 VDG N GRL + PCTP+G + L++ + G +AVV+G S IVG PM Sbjct: 124 VDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHD 183 Query: 178 ELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 LL T T H T +L V D+L+VA G+P + G+WIK GAIVID GIN + + Sbjct: 184 LLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYVPD 243 Query: 238 ------GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 KVVGDV +++A +RAS+ITPVPGGVGPMTVA L+++T+++ + + Sbjct: 244 DKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLE 296 >UniRef50_D2QZP8 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2QZP8_9PLAN Length = 293 Score = 358 bits (920), Expect = 1e-97, Method: Composition-based stats. Identities = 139/289 (48%), Positives = 179/289 (61%), Gaps = 10/289 (3%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M +IDG+ I + + E+A++V I RAP LA VLVG +PAS +YV +K ACE Sbjct: 1 MTHVVIDGRAIGRVIELEIAEQVADFIQNNGRAPCLAAVLVGDDPASAVYVKNKHLACER 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG S+ + L +TSE ELL+LI LN D I GILVQLPLP+ I + VL+ +HP KDV Sbjct: 61 VGIESKLHRLAGSTSEEELLDLIAMLNDDPAISGILVQLPLPSQIRSTYVLDAVHPLKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 D FHP NVG L Q PR PCTP G + +L R + G + ++G S+IVGRP++ L Sbjct: 121 DCFHPENVGLLTQGRPRYLPCTPHGCLQILHRTGLSVAGKHVAIVGRSDIVGRPLATLLS 180 Query: 181 LA---------GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVG 231 T T+ H +KNL AD+LI A+GKP F+ D +K GAIVIDVG Sbjct: 181 QKDSHLSPEICNATVTLLHSRSKNLAAMTREADVLIAAIGKPKFVTADMVKPGAIVIDVG 240 Query: 232 INRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 INRL G + GDV F+ A +SYITPVP GVGP+T+ L++NTL A Sbjct: 241 INRLPEG-LCGDVDFDSVAPISSYITPVPKGVGPLTITMLLQNTLAAAR 288 >UniRef50_C2E8X3 Methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase n=1 Tax=Lactobacillus ruminis ATCC 25644 RepID=C2E8X3_9LACO Length = 284 Score = 356 bits (915), Expect = 4e-97, Method: Composition-based stats. Identities = 117/278 (42%), Positives = 182/278 (65%), Gaps = 1/278 (0%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +I++G+ ++ +V+ + + V+ G+ P LAV+LVG + AS++YV +K +A E++G Sbjct: 3 EIMNGRDLSAKVKMNLKKSVEGLKKVGV-TPALAVILVGDDEASKVYVKNKHRAAEKIGI 61 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + +P + + +++++I+ N D + GILVQ+PLP ID +++ I P KDVDG Sbjct: 62 KTIDETMPADSKQEDVIKMIEKYNNDPDVHGILVQMPLPKHIDEKAIIDAIDPKKDVDGS 121 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 HP N+GRL + PCTPRGI+ LL+ Y+ID G V++G SN+VGRP++ ++ + Sbjct: 122 HPENMGRLFMNESQALPCTPRGIMELLKEYDIDVRGQEVVIVGRSNLVGRPLAALMINSS 181 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T TV H T +L+ + AD+L+ AVGK D+IKEGA+VIDVGINR GK+ GD Sbjct: 182 ATVTVAHSVTHDLQSVTKKADILVAAVGKAKMFTKDYIKEGAVVIDVGINRTAEGKLCGD 241 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 V +D +A+++TPVPGGVGPMTVA L++ T++ Sbjct: 242 VDAKDVMGKAAFLTPVPGGVGPMTVAMLMKQTVEFAER 279 >UniRef50_Q8DMU0 Methenyltetrahydrofolate cyclohydrolase n=80 Tax=Bacteria RepID=FOLD_THEEB Length = 306 Score = 356 bits (915), Expect = 4e-97, Method: Composition-based stats. Identities = 141/290 (48%), Positives = 191/290 (65%), Gaps = 4/290 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 AA +DGK++AQ + ++A V+ A R+PGLAV+ VG++PAS +YV +K +AC V Sbjct: 5 AATCLDGKSLAQSIERQLADHVRTFQAQWGRSPGLAVLRVGNDPASAVYVRAKEQACSRV 64 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S LP T +EA LL I LN D +DGIL+QLPLP +D +L IHPDKDVD Sbjct: 65 GIQSFGAHLPATITEAALLAKITELNQDERVDGILLQLPLPPHLDPRPLLYAIHPDKDVD 124 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G HP N+GRL + P LR CTP G++ LL Y ID G +AVV+G S +VG+P+++ LL Sbjct: 125 GLHPENLGRLVRDEPGLRSCTPAGVMQLLAAYGIDVVGRSAVVVGRSILVGKPLALMLLS 184 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE--NGK 239 A T T+ H ++ L +A++L+ A+G+P I D I+ GA+VIDVGINR++ +GK Sbjct: 185 ANATVTIAHSRSRELASITRSAEILVTAMGQPRRITADMIRPGAVVIDVGINRIQRPDGK 244 Query: 240 --VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQD 287 + GDV +E A ASYITPVPGGVGPMTVA L+ NT+ + H+ Q Sbjct: 245 SSLWGDVDYEAARAVASYITPVPGGVGPMTVAMLLHNTVWSYCRRHNWQQ 294 >UniRef50_UPI0001BC5140 bifunctional protein FolD n=3 Tax=Fusobacterium RepID=UPI0001BC5140 Length = 292 Score = 356 bits (913), Expect = 7e-97, Method: Composition-based stats. Identities = 123/278 (44%), Positives = 175/278 (62%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 K++DGK ++ +++ E+ K++ R PGL ++ +G N A+ +YV S+ K +G Sbjct: 2 KLLDGKKVSAEIKEELKSKIREEKERSGRVPGLGIIQIGHNEAASVYVQSQLKGSRALGM 61 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S Y ++ E +L+ I LN IDGI++QLPLP I + ++L+ I +KDVDGF Sbjct: 62 ESYLYSFDDSVEEETVLKKIKELNQTEEIDGIILQLPLPKHISHSRILQAIDVNKDVDGF 121 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 N+GRL PCTP G++ LL++Y+I+ N +IG SNIVG+PM + Sbjct: 122 KTENIGRLHLGEEGFNPCTPEGVIALLKKYDIEIASKNVTIIGRSNIVGKPMLGLFINHN 181 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T T+ + TKNL+ H E AD+++VAVGK F+ D ++EGAIVIDVGINR GK+VGD Sbjct: 182 ATVTICNSLTKNLKEHTERADIIVVAVGKEKFLTADMVREGAIVIDVGINRSREGKIVGD 241 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 V FE A +ASYITPVPGGVG MTVA L +N +A + Sbjct: 242 VDFEAVAPKASYITPVPGGVGSMTVAMLFQNIWKAFIR 279 >UniRef50_B3ESU1 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Bacteria RepID=FOLD_AMOA5 Length = 298 Score = 355 bits (912), Expect = 8e-97, Method: Composition-based stats. Identities = 130/291 (44%), Positives = 174/291 (59%), Gaps = 10/291 (3%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A I+DGK +A +R +A++VQ G P LA+VLVG +PAS YV +K KAC+EV Sbjct: 1 MAVILDGKQVAHFLRQSLAEQVQTLAKEGKPIPHLAIVLVGDDPASHTYVYNKVKACQEV 60 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 GF + E+ LL LI LN D +I GI++QLPLP I+ +K+++ I P KDVD Sbjct: 61 GFQTTFIQEASHVQESTLLYLIHKLNEDTSIHGIIIQLPLPKHINAIKIIQAITPSKDVD 120 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G H +N GR+ P P TP GI+ LLE Y I+T G + V+IG VG P+S+ + Sbjct: 121 GLHTFNYGRMACNLPTHIPATPLGILLLLEHYQIETAGKHCVIIGRGPTVGAPLSILMSR 180 Query: 182 A----GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 T T+ H +T+ L + AD+L+VAVGKPG I D IK VIDVGI R+ + Sbjct: 181 NAYPGNATVTLCHSYTQQLTNFTRQADILVVAVGKPGLITADMIKPSTTVIDVGITRIPD 240 Query: 238 G------KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 ++ GDV FE+ A + ITPVPGGVGPMT+A L+ NTL+A Sbjct: 241 TTKKRGYRLKGDVAFEEVATLCNAITPVPGGVGPMTIAALLTNTLRAATNQ 291 >UniRef50_Q11UD1 Methenyltetrahydrofolate cyclohydrolase n=6 Tax=Bacteria RepID=FOLD_CYTH3 Length = 290 Score = 355 bits (912), Expect = 1e-96, Method: Composition-based stats. Identities = 143/287 (49%), Positives = 192/287 (66%), Gaps = 10/287 (3%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +++DGK + Q++ E+ KV+A A G + P LA VLVG + A+ YV +K KACE VGF Sbjct: 2 QLLDGKITSDQIKEELKTKVEAIKAKGGKIPHLAAVLVGDSGAAVTYVNAKVKACELVGF 61 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S LPET +EA+LL + +NAD IDG +VQLPLP ID KV E I PDKDVDGF Sbjct: 62 KSTLVKLPETITEADLLAKVAEINADKDIDGYIVQLPLPKHIDEQKVTEAISPDKDVDGF 121 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA- 182 HP ++GR+ P P TP GI+ LLER I+T G + VV+G S+IVG PMS+ + Sbjct: 122 HPTSLGRMVLNLPTYLPATPYGIMQLLERNGIETSGKHCVVMGRSHIVGSPMSILMARNT 181 Query: 183 ---GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG- 238 T T+ H TKNL+ AD+LIVA+GKP F+ D +KEGA+V+DVGI+R+++ Sbjct: 182 NPGNATVTMVHSRTKNLKELTLQADILIVAIGKPEFVTADMVKEGAVVVDVGIHRIDDAT 241 Query: 239 -----KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 +++GDV F++ A + SYI+PVPGGVGPMT+A+L+ NTLQA Sbjct: 242 KKSGFRLLGDVKFDEVAPKTSYISPVPGGVGPMTIASLLMNTLQAAA 288 >UniRef50_B0TFC9 Methenyltetrahydrofolate cyclohydrolase n=7 Tax=Clostridia RepID=FOLD_HELMI Length = 287 Score = 355 bits (911), Expect = 1e-96, Method: Composition-based stats. Identities = 131/276 (47%), Positives = 166/276 (60%), Gaps = 1/276 (0%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A+ IDGK IA Q+R+E+ +V + G+ P LAV+LVG +PAS +Y SK KA Sbjct: 1 MTAQYIDGKAIAAQLRAEIKAEVASLREQGI-VPKLAVILVGDDPASVVYARSKEKAAAN 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G + LP T+EA LL LI+ LNAD + GI+V+LPLP I KVLE IHP KDV Sbjct: 60 LGIAFELFTLPGDTTEAALLALIERLNADAAVHGIMVELPLPKQISKEKVLEAIHPLKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG HP N G L P L P TP + LL R ++ G V+IG VG+P+ LL Sbjct: 120 DGVHPLNRGYLMAGQPGLVPATPMSCMELLARSGVELAGKRVVIIGRGETVGKPLFFLLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T TV H TK+L V A+++I A GK G + G+ I A+VID GIN E+G + Sbjct: 180 RRNATVTVCHTRTKDLAAEVRRAEIVIAAAGKAGLVTGEMIAPDAVVIDAGINEGEDGNI 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 VGDV +AA+RAS I+PVPGGVG T A L N L Sbjct: 240 VGDVKTAEAAERASLISPVPGGVGACTTALLFRNVL 275 >UniRef50_Q17W13 Methenyltetrahydrofolate cyclohydrolase n=14 Tax=Helicobacter RepID=FOLD_HELAH Length = 292 Score = 354 bits (910), Expect = 2e-96, Method: Composition-based stats. Identities = 132/279 (47%), Positives = 184/279 (65%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 ++DG+ +A + ++ K+QA + P LAV+LVG +PAS YV K KACE VG Sbjct: 10 LLDGQALAYNIEEDLKYKIQAINTQTHKRPKLAVILVGKDPASITYVNMKIKACERVGMD 69 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 L E +EA+LL LI N + I G+LVQLPLP ID+ + E I P+KDVDGFH Sbjct: 70 FDLKTLQENITEAQLLSLIKDYNNNQNISGVLVQLPLPRHIDSKMISEAIDPNKDVDGFH 129 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 P N+G+LC + P TP G++ LLE Y+I G + +IGASNI+G+P+SM +L AG Sbjct: 130 PLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAIIGASNIIGKPLSMLMLNAGA 189 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 + +V H TK++ + +NAD++ V VGKP I +K+GA+V+D+GIN L +G++VGDV Sbjct: 190 SVSVCHILTKDINFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGDV 249 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 F +A K AS+ITPVP GVGPMT+ +L+ENTL A + Sbjct: 250 DFTNAQKVASFITPVPKGVGPMTIVSLLENTLIAFEKQQ 288 >UniRef50_C7TD85 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase n=5 Tax=Bacteria RepID=C7TD85_LACRG Length = 283 Score = 352 bits (905), Expect = 6e-96, Method: Composition-based stats. Identities = 131/283 (46%), Positives = 180/283 (63%), Gaps = 1/283 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A +DG+ +++++ E+ Q V A P LAVVLVGS+PAS++YV +K++ EE+ Sbjct: 1 MATRLDGRVVSKKILGELKQTVAKL-AQQDVTPTLAVVLVGSDPASEVYVRNKQRRAEEI 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S Y LPE TS+ LL + LN D +D ILVQLPLPAG+D V++ I P+KDVD Sbjct: 60 GVRSLMYRLPEDTSQMTLLAKVAELNQDPDVDAILVQLPLPAGLDERAVIDAIDPNKDVD 119 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GF P +VGRL P + TP GI+ LL+ Y+ID G V++G SNIVGRP++ ++ Sbjct: 120 GFSPVSVGRLWTNEPTVVASTPYGIMALLDAYDIDVAGQRVVIVGRSNIVGRPLAGLMVN 179 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 T T+ H T+NL+ AD+L+VAVG+P FI D +K GA VIDVGI+R +GK+ Sbjct: 180 HDATVTIAHSKTRNLKQLTREADILVVAVGRPHFIGADAVKPGATVIDVGISRGADGKLH 239 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 GDV + A A +TPVPGGVGPMT+A+L+ T+ Sbjct: 240 GDVDDDTVAPIAGALTPVPGGVGPMTIASLMAQTVALAKRRLH 282 >UniRef50_A9A4N5 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=Thaumarchaeota RepID=FOLD_NITMS Length = 287 Score = 351 bits (902), Expect = 1e-95, Method: Composition-based stats. Identities = 130/281 (46%), Positives = 176/281 (62%), Gaps = 4/281 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M IDGK I+Q V+ V + V+ G+ P LA VLVG NPAS YV +K +ACEE Sbjct: 1 MTGTKIDGKVISQSVKDRVKKAVEELKNQGIN-PCLATVLVGDNPASATYVRNKHRACEE 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG ++ + L +T++A+L E+I+ LN DN++ GILVQLPLP +D RI P KDV Sbjct: 60 VGITTKDHKLDASTTQAQLNEIIENLNNDNSVHGILVQLPLPEQLDEFTTTSRISPLKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG P+N G L + L CTP G++ + + + I+ G N V+I SN+VG+P+ LL Sbjct: 120 DGLTPHNAGLLAMKKAALVACTPSGVMEMFDYHGIELEGKNIVLINRSNLVGKPLYHLLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPG--FIPGDWIKEGAIVIDVGINRLENG 238 T H TKNL ++AD++I AVG + D IKEGAIVIDV I+R + Sbjct: 180 DKNATVITCHSRTKNLVELCQSADIIITAVGDRNKFTLTSDMIKEGAIVIDVAISRFQE- 238 Query: 239 KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 K+VGD +ED ++AS+ TPVPGGVGPMTVA L++NT+ A Sbjct: 239 KLVGDADYEDIIQKASFATPVPGGVGPMTVAMLLKNTITAA 279 >UniRef50_Q1II76 Methenyltetrahydrofolate cyclohydrolase n=15 Tax=Bacteria RepID=FOLD_ACIBL Length = 307 Score = 349 bits (897), Expect = 5e-95, Method: Composition-based stats. Identities = 139/302 (46%), Positives = 188/302 (62%), Gaps = 24/302 (7%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A I+DG I+ ++++EVA +V A GL PGLAVVLVG NPAS+IYV +K KACE Sbjct: 1 MLATILDGNKISAEIKTEVAAEVAELKAKGL-TPGLAVVLVGHNPASEIYVRNKVKACEM 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 G S + P+T S A+LL+L+++LN N IDGILVQLPLP +D+ K+L + P+KDV Sbjct: 60 TGIYSEQHTPPDTVSTADLLQLVESLNRRNDIDGILVQLPLPKQVDSKKILLAVSPEKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP NVG L P L PCTP G + +L R N+ G +AVV+G S+IVG+P++M L Sbjct: 120 DGFHPMNVGYLSTVRPGLVPCTPAGCMEILRRSNVPVEGADAVVVGRSDIVGKPIAMLLT 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN--- 237 A T T+ H T +L AD+L+ A+G+PG I D++K GA V+DVGIN++ + Sbjct: 180 NANATVTICHSKTHDLPAVCRRADILVAAIGRPGMITPDFVKPGATVLDVGINKITDRAE 239 Query: 238 -------------------GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 +VGD A+ A TPVPGGVGP+T+A L+ NT++A Sbjct: 240 FEKFFAGDAKREAAFAKNGSTLVGD-CHPKVAEVAGAFTPVPGGVGPLTIAMLMANTVKA 298 Query: 279 CV 280 Sbjct: 299 AK 300 >UniRef50_D0GMJ6 Bifunctional protein FolD n=2 Tax=Leptotrichia RepID=D0GMJ6_9FUSO Length = 283 Score = 349 bits (896), Expect = 6e-95, Method: Composition-based stats. Identities = 130/278 (46%), Positives = 190/278 (68%), Gaps = 2/278 (0%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 IDGK I+Q++ + ++ + R GLAV++ G+NPAS++YV +K KACE V F S Sbjct: 4 IDGKDISQKILKYIEKEHKLLRDKYERTAGLAVIMAGNNPASEVYVKNKIKACESVKFYS 63 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 L E +EA+ ++ I+ N ++ IDGIL+QLPLP I+ +KV+ + P+KDVDGFH Sbjct: 64 EIVRLDENVTEADFIKEIERFNKNDKIDGILIQLPLPEHINELKVINAVSPEKDVDGFHV 123 Query: 126 YNVGRLCQR-APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 N+G++ PCTP GI+ LLE Y+ID G + V++G SNIVG+P+++ L+ Sbjct: 124 VNIGKMMTGDKSGFWPCTPYGIIQLLEEYDIDPAGKDVVIVGRSNIVGKPLALMLIEKSA 183 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T V + TKN+R ++NAD++I A G P I + IKEGA+VIDVGINR+ NGK+ GDV Sbjct: 184 TVQVCNTKTKNIREKLKNADIVIAAAGVPNLISAEDIKEGAVVIDVGINRV-NGKLCGDV 242 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 +E+ +++A YITPVPGGVGPMT+A+LI+NT ++ + Sbjct: 243 NYEEVSEKAGYITPVPGGVGPMTIASLIKNTFKSYINK 280 >UniRef50_B2S3X1 Methenyltetrahydrofolate cyclohydrolase n=35 Tax=cellular organisms RepID=FOLD_TREPS Length = 315 Score = 349 bits (896), Expect = 7e-95, Method: Composition-based stats. Identities = 130/288 (45%), Positives = 174/288 (60%), Gaps = 8/288 (2%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A++IDGK A + + +A +VQA AA AP LA VLVG +PAS YVA+K++A Sbjct: 1 MDARLIDGKQAAHECTARLATRVQALRAAVGTAPFLAAVLVGDDPASCTYVAAKQRALAR 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 ++ LP S A++LELI LN D + GIL+QLPLPA +D +V + P+KDV Sbjct: 61 AHLRGETHRLPAHASHAQVLELIARLNEDARVHGILIQLPLPAHLDAARVCRAVAPEKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP N G L P PCTP GIV LL R + G V++G S IVGRP+++ L Sbjct: 121 DGFHPLNCGALFLAQPGFVPCTPAGIVHLLRRAQVPLAGARVVIVGRSAIVGRPLAVLLA 180 Query: 181 LAGC--TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 GC T T+ H T+ L AD+L+ A+GK FI +++ GA+VIDVGI+ + + Sbjct: 181 SPGCDATVTLCHSHTRGLADICVQADILVAALGKARFIGAPFVRTGAVVIDVGIHHVPDA 240 Query: 239 ------KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 ++ GDV F+ A + ITPVPGGVGPMT+A L+ NTL A Sbjct: 241 TAPRGRRLCGDVDFDAVAHKVQAITPVPGGVGPMTIAMLLHNTLCAAE 288 >UniRef50_Q1QD30 Methenyltetrahydrofolate cyclohydrolase n=50 Tax=Bacteria RepID=FOLD_PSYCK Length = 298 Score = 348 bits (894), Expect = 1e-94, Method: Composition-based stats. Identities = 125/280 (44%), Positives = 173/280 (61%), Gaps = 1/280 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 +A ++DGK +A+Q+ ++ +V A A R P LA +LVG +PAS YV K AC+ V Sbjct: 13 SATVLDGKALAKQIEQQLRTRVDAIKAKTGRTPSLATILVGDDPASATYVRMKGNACKRV 72 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S ++P T+ AEL+ I LN+ + GIL+Q P+PA ID E+I KDVD Sbjct: 73 GMDSIRVEMPSVTTTAELMAKIYELNSSPDVHGILLQHPVPAHIDERACFEKIDLAKDVD 132 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G GR+ + CTP+GI+ LLE++NI+ GL AVV+G S I+G+PM+M LL Sbjct: 133 GVTCLGFGRMAMQQSAYGSCTPQGIMHLLEQHNIELAGLEAVVVGRSAILGKPMAMMLLN 192 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 A CT T+ H T++L H++ AD+++ AVG P I DWIK GA+VID G + +NG V Sbjct: 193 ANCTVTICHSRTQDLESHIKRADIIVGAVGVPELIKADWIKAGAVVIDAGFHPTDNGG-V 251 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 GD+ + AS TPVPGGVGPMT+ TLI T+ A + Sbjct: 252 GDIELQGVENIASAYTPVPGGVGPMTINTLIRQTVDAAEK 291 >UniRef50_Q049N0 Methenyltetrahydrofolate cyclohydrolase n=18 Tax=Firmicutes RepID=FOLD_LACDB Length = 283 Score = 348 bits (894), Expect = 1e-94, Method: Composition-based stats. Identities = 123/282 (43%), Positives = 186/282 (65%), Gaps = 2/282 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 +I+DGK +A+++ ++ +V + G+ +P L V+ +G +PAS++YVASK++ E++ Sbjct: 1 MGEILDGKKLARELGEKLGSEVDSLKEHGV-SPKLCVINIGDDPASKVYVASKKRKAEKL 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G Y LP SE ++L+LID+LNAD + ++VQLP+P I+ +V+ERI P+KDVD Sbjct: 60 GIKQVVYQLPADESEEDVLKLIDSLNADPEVSSLMVQLPVPPQINADRVIERIDPEKDVD 119 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 P N+GRL Q + P T GI+ LL+ Y ID G NAV++G SNIVG+P++ +L Sbjct: 120 CLTPANIGRLWQGKHFVEPATAAGIIALLDHYQIDLTGKNAVIVGRSNIVGKPLAALMLE 179 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 + ++ H ++NL + AD+L+ AVGK I D +KEGA+VIDVGINR+ +G +V Sbjct: 180 RNASVSILHSRSRNLADLTKQADILVCAVGKAEMIKADMVKEGAVVIDVGINRV-DGHLV 238 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 GDV F ++AS+ITPVPGGVGP+TV L+E ++ H Sbjct: 239 GDVDFAPVKEKASWITPVPGGVGPLTVEFLMEEVIKLTRRQH 280 >UniRef50_A5VAA8 Methenyltetrahydrofolate cyclohydrolase n=107 Tax=cellular organisms RepID=FOLD3_SPHWW Length = 304 Score = 348 bits (893), Expect = 1e-94, Method: Composition-based stats. Identities = 154/285 (54%), Positives = 184/285 (64%), Gaps = 5/285 (1%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A+IIDGK A +R+ VA V A A RAPGLAVVLVG + ASQ+YV SK KA E G Sbjct: 9 AEIIDGKAYAAGLRARVATAVPAFRVAAGRAPGLAVVLVGEDAASQVYVRSKHKATVEAG 68 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 S + LP T SE ELL L++ LNAD+ +DGILVQLPLP ID KV+ I PDKDVDG Sbjct: 69 MESFEHRLPATASETELLALVERLNADDRVDGILVQLPLPPHIDEKKVIATIDPDKDVDG 128 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 FH N GRL PCTP G + LL+ D GL AVVIG SNIVG+PM+ LL Sbjct: 129 FHVVNAGRLAVGEAGYVPCTPLGCLMLLKDRRGDLSGLEAVVIGRSNIVGKPMAALLLAE 188 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE-----N 237 CT T+ H T++L V AD+++ AVG+P + GDWI+ GA VIDVGINR+ Sbjct: 189 NCTVTIAHSRTRDLAEVVRRADIVVAAVGRPEMVRGDWIRPGATVIDVGINRVPGAEPGK 248 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 ++VGDV F +AA A ITPVPGGVGPMT+A L+ NTL A Sbjct: 249 TRLVGDVAFAEAAAVAGAITPVPGGVGPMTIAVLLRNTLVAAHRR 293 >UniRef50_Q9X7F6 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Methylobacterium chloromethanicum CM4 RepID=FOLD_METC4 Length = 306 Score = 348 bits (893), Expect = 2e-94, Method: Composition-based stats. Identities = 137/283 (48%), Positives = 178/283 (62%), Gaps = 3/283 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A++IDG+ A ++ V + R PGLAVVL+G +PAS +YV +K + Sbjct: 1 MIAQVIDGRAEAARLTDNVRARAHRFTDEFGRCPGLAVVLIGDDPASSVYVKAKTEKARS 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 G +S S+ LP T+E LL LID LN D T+DGILVQLPLP I +VL+RI P KDV Sbjct: 61 TGILSSSHRLPSDTTEDALLRLIDQLNRDRTVDGILVQLPLPPHIAPERVLQRILPCKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP N G L P L PCTP G + L++ + G N VV+G S IVGRP + L Sbjct: 121 DGFHPVNAGLLATGQPGLVPCTPLGCLRLVQSVAAELVGQNVVVVGRSTIVGRPAAQVFL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE---N 237 A C+ T+ H+ ++++ H +AD+L+VA G PG + DW+K GA+VIDVGINR+ Sbjct: 181 NADCSVTILHKESRDVPGHCRSADILVVAAGSPGLVRRDWVKPGAVVIDVGINRIPVSSG 240 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 ++VGDV FE AS ITPVPGGVGPMTVA L+ENT+ Sbjct: 241 YRLVGDVDFEGVQYVASAITPVPGGVGPMTVAALMENTVACAE 283 >UniRef50_Q8RAD0 Methenyltetrahydrofolate cyclohydrolase n=11 Tax=Thermoanaerobacterales RepID=FOLD_THETN Length = 280 Score = 347 bits (890), Expect = 3e-94, Method: Composition-based stats. Identities = 122/280 (43%), Positives = 176/280 (62%), Gaps = 6/280 (2%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M IIDGK I+ +++ EV +++Q P LA+++ G + +S++Y SK KACE Sbjct: 1 MKRMIIDGKEISNRIKEEVKREIQEF----GYKPRLAILMAGDDESSKVYANSKVKACES 56 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG ++ Y E E + + ++ LN D GI++++PLP G D KV + I+P KDV Sbjct: 57 VGIEAKVYYFSEK-EEDKFFDTLEKLNEDKDTHGIMIEMPLPKGFDVDKVYDTINPYKDV 115 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 D YN+GRL P PCTP+ I+ +LE +D G +AVVIG SNI+G+P++ LL Sbjct: 116 DCISNYNMGRLFAGKPLFVPCTPKAIIHILENTGVDLEGKHAVVIGRSNILGKPVAKLLL 175 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 CT TV H TK+L +H + AD+L+VA GK + GD +KEG ++ID GIN + GK+ Sbjct: 176 DKNCTVTVCHSKTKDLAYHTKQADVLVVAAGKMNLVRGDMVKEGVVLIDAGIN-VHEGKI 234 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 GD FE +ASY+TPVPGGVGP+T A +++NTL+A Sbjct: 235 YGDADFESIKDKASYVTPVPGGVGPVTTAMILKNTLEAFK 274 >UniRef50_B1GZ24 Bifunctional protein FolD n=2 Tax=Bacteria RepID=B1GZ24_UNCTG Length = 296 Score = 346 bits (888), Expect = 5e-94, Method: Composition-based stats. Identities = 130/287 (45%), Positives = 176/287 (61%), Gaps = 9/287 (3%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 K+IDGK I+ R+E+ ++V + PGLA VLVG +PAS++Y+ SK KACE+ G Sbjct: 2 KLIDGKKISSDKRAEIKEEVAKIKQQTEKIPGLATVLVGGDPASRVYIKSKIKACEDAGI 61 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S ++L +S+ E++ LI LN ++ IDGIL+QLPLP D + L + P KDVDG Sbjct: 62 KSFHHNLDANSSKEEIIALIKKLNENSEIDGILLQLPLPQNKDAQECLNAVSPLKDVDGL 121 Query: 124 HPYNVGRL--------CQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPM 175 HP+N G L L CTP G+V +L + I G AVVIG SN+VG+P+ Sbjct: 122 HPFNAGLLNLSKSWNEIIEKNILVSCTPLGVVHILHKSGIIIEGKTAVVIGRSNLVGKPL 181 Query: 176 SMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL 235 SM LL T + H T+NL+ ++AD+++ AVGK F+ D+IK GA+VIDVGINR Sbjct: 182 SMLLLANNATVIMAHSKTRNLKEICKSADIVVAAVGKSKFVNKDFIKTGAVVIDVGINRT 241 Query: 236 ENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 G + GDV F+ ITPVPGGVGPMT+ L+ENTL+A Sbjct: 242 SEG-LCGDVDFDAVKDMDIKITPVPGGVGPMTITMLLENTLKAFNNR 287 >UniRef50_UPI00015B59A5 PREDICTED: similar to ENSANGP00000016878 n=2 Tax=Eumetazoa RepID=UPI00015B59A5 Length = 866 Score = 345 bits (886), Expect = 9e-94, Method: Composition-based stats. Identities = 118/290 (40%), Positives = 171/290 (58%), Gaps = 10/290 (3%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAG-LRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 ++ G +A+++R +A+ V A APGLA+V VG S +Y+ K KA E+G Sbjct: 9 VLSGTDLAKEIRESLAKDVAAIQQKLPNYAPGLAIVQVGGREDSNVYIRMKIKAASEIGI 68 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPA--GIDNVKVLERIHPDKDVD 121 + +P TT+E ELL ++ LN D GI+VQ+PL + I++ + + + PDKDVD Sbjct: 69 KATHVKMPNTTTEHELLTKLNKLNNDPDTHGIIVQMPLDSVNKINSHLITDTVSPDKDVD 128 Query: 122 GFHPYNVGRLCQRA-PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 G + N GR+ PCTP G + L++R + G AVV+G S IVG P++ L Sbjct: 129 GLNTINEGRVAIGDMSGFLPCTPNGCIELIKRSGVPIAGAQAVVLGRSKIVGTPVAELLK 188 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-- 238 T TV H TK+L V AD+++V +G+P + G WIK GA+VID GIN + + Sbjct: 189 WHNATVTVCHSRTKDLPSVVSKADIVVVGIGQPELVKGSWIKPGAVVIDCGINSIPDPTK 248 Query: 239 ----KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 ++VGDV + +AAK ASYITPVPGGVGPMTVA L++NT+ + + Sbjct: 249 KSGQRLVGDVDYAEAAKVASYITPVPGGVGPMTVAMLMKNTVISAQRAAE 298 >UniRef50_D0MY89 Bifunctional folD protein n=1 Tax=Phytophthora infestans T30-4 RepID=D0MY89_PHYIN Length = 307 Score = 345 bits (885), Expect = 1e-93, Method: Composition-based stats. Identities = 125/304 (41%), Positives = 182/304 (59%), Gaps = 16/304 (5%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 MAA++IDGK IA+ +R+ + V A A RAP L +++VG S +YV +K AC Sbjct: 1 MAARLIDGKAIAKALRAALKGDVAALTAKHGRAPALGLIMVGDRKDSALYVRNKNTACRR 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPA-GIDNVKVLERIHPDKD 119 G S ++ E S+ +++ ++ LN D +IDGILVQLPLP ++ ++++RI DKD Sbjct: 61 TGIRSENFLFDEGVSQDTIVQKVEELNEDPSIDGILVQLPLPGTQLNAQQIIDRIQHDKD 120 Query: 120 VDGFHPYNVGRLCQRA--PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSM 177 VDG HP+N G L R P L PCT +GI+ LL+ + G AV+IG SN+VG P+SM Sbjct: 121 VDGLHPFNAGELAMRGRYPYLIPCTAKGILALLDEQHTPLRGKTAVIIGRSNLVGNPVSM 180 Query: 178 ELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 L TT + H T +L +V AD+++ A G+P + G+W+K GA V+DVGIN + + Sbjct: 181 LLQKRDATTILCHSKTVDLPRYVRQADVVVAACGQPYLVRGEWLKPGATVVDVGINFVRD 240 Query: 238 -------------GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 K+VGDV F +A + A +TPVPGGVGPMT+A L+ N ++A D Sbjct: 241 VDGEFHGEANADGFKLVGDVNFHEACEVAGALTPVPGGVGPMTIAMLLHNVVEAFKRKMD 300 Query: 285 PQDE 288 + + Sbjct: 301 NRKK 304 >UniRef50_Q9H903 Methenyltetrahydrofolate cyclohydrolase n=75 Tax=cellular organisms RepID=MTD2L_HUMAN Length = 289 Score = 342 bits (879), Expect = 5e-93, Method: Composition-based stats. Identities = 128/286 (44%), Positives = 173/286 (60%), Gaps = 15/286 (5%) Query: 11 IAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDL 70 +A+ ++ E+ + V++ ++ G R P L+++LVG NPAS YV +K +A VG S Sbjct: 1 MAKHIQKEIQRGVESWVSLGNRRPHLSIILVGDNPASHTYVRNKIRAASAVGICSELILK 60 Query: 71 PETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGR 130 P+ S+ ELL++ D LN D + GILVQLPLP +D + I P+KDVDGFH N+GR Sbjct: 61 PKDVSQEELLDVTDQLNMDPRVSGILVQLPLPDHVDERTICNGIAPEKDVDGFHIINIGR 120 Query: 131 LCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG------- 183 LC L P T + +++R I TFG N VV G S VG P++M L G Sbjct: 121 LCLDQHSLIPATASAVWEIIKRTGIQTFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGG 180 Query: 184 -CTTTVTHRFTK--NLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-- 238 T T+ HR+T L+ H + AD++IVA G P I D +KEGA VIDVGIN + + Sbjct: 181 DATVTIAHRYTPKEQLKIHTQLADIIIVAAGIPKLITSDMVKEGAAVIDVGINYVHDPVT 240 Query: 239 ---KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 K+VGDV FE K+A +ITPVPGGVGPMTVA L++NTL A + Sbjct: 241 GKTKLVGDVDFEAVKKKAGFITPVPGGVGPMTVAMLLKNTLLAAKK 286 >UniRef50_C8P269 Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase n=1 Tax=Erysipelothrix rhusiopathiae ATCC 19414 RepID=C8P269_ERYRH Length = 284 Score = 342 bits (878), Expect = 8e-93, Method: Composition-based stats. Identities = 131/276 (47%), Positives = 180/276 (65%), Gaps = 2/276 (0%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+DG +++ +R+ + + + I G RAP L VV+VG +PASQ YV SK K C+ VGF Sbjct: 4 ILDGLAVSKAIRASLKDETEVLIKQGKRAPSLTVVIVGDDPASQTYVNSKVKQCKSVGFS 63 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S++ T++ LL++I TLN DN +DGILVQLPLP ID ++E I P KDVDG H Sbjct: 64 SQAISCEVDTTQEALLKIIRTLNHDNDVDGILVQLPLPKHIDENVIIEAIDPQKDVDGLH 123 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 P NVG L P CTP+GIV LL+ YN++ G A+VIG S +VG+P+S L Sbjct: 124 PLNVGYLELNRPGFVSCTPKGIVRLLDWYNVELEGKRALVIGRSRLVGKPVSTLLSQKNA 183 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+ H TKNL V + D+++VA+GKP IP WI + +++DVGI+R+ +G + GDV Sbjct: 184 TVTLAHSKTKNLEELVRSNDIIVVAMGKPEAIPASWISDQHVLVDVGIHRI-DGNLRGDV 242 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 A + A+Y TPVP GVGPMT+A+L+ENT+ A Sbjct: 243 D-RRAYEIAAYATPVPKGVGPMTIASLLENTMIAYK 277 >UniRef50_C5BI30 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=Bacteria RepID=FOLD_TERTT Length = 280 Score = 342 bits (877), Expect = 9e-93, Method: Composition-based stats. Identities = 121/282 (42%), Positives = 169/282 (59%), Gaps = 4/282 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M+A I+DGK +AQ+ +E++++V A + R P LA +LVG +PAS YV K AC Sbjct: 1 MSALILDGKALAQKTEAELSERVAALKSKTGRTPILATILVGGDPASATYVRMKGNACTR 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G S +LPETT+ ELL I LN + + GIL+Q P+P+ ID + I KDV Sbjct: 61 IGMDSMKVELPETTTTDELLAKIAELNNNPDVHGILLQHPVPSQIDERACFDAIDLSKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG GR+ TP+GI+ LLE Y I G +AVV+G S I+G+PM++ LL Sbjct: 121 DGVTCLGFGRMAMGEEAYGCATPKGIMRLLEAYEIPLEGKHAVVVGRSPILGKPMALMLL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 A T T+ H TK+L+ H+ AD+++ AVG P FI DWIK GA+V+D G + Sbjct: 181 NANATVTICHSRTKDLQSHIATADIVVGAVGIPEFIKADWIKPGAVVVDAGYHPGG---- 236 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 VGD+ A +AS +TPVPGGVGPMT+ TLI ++ + + Sbjct: 237 VGDIELGPLADKASALTPVPGGVGPMTINTLIYQSVDSGEKK 278 >UniRef50_D0J906 Putative methenyltetrahydrofolate cyclohydrolase n=1 Tax=Blattabacterium sp. (Periplaneta americana) str. BPLAN RepID=D0J906_BLASP Length = 292 Score = 341 bits (876), Expect = 1e-92, Method: Composition-based stats. Identities = 126/286 (44%), Positives = 182/286 (63%), Gaps = 8/286 (2%) Query: 4 KIIDGKTIAQQVRSEVAQKVQA-RIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 ++++G +A +R E++++++ R P L ++L+G+N +S YV SK + C+ +G Sbjct: 3 QLLNGNKLAIDIRKEISKEIEKSIRNKKKRLPHLGIILLGTNSSSLTYVNSKIQECKNIG 62 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 S LP +SE ELL+ I +N + IDG +VQLPL I++ K++ I+P KDVDG Sbjct: 63 IKSSLIHLPNDSSEKELLKEIQKMNNNPLIDGFIVQLPLQKHINSDKIIMSINPRKDVDG 122 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 FHP N G++ P T GI+T+LERY I+ G + VVIG S IVGRP+S+ + Sbjct: 123 FHPENFGKMSLDMKAFFPATALGILTILERYKIEISGKHTVVIGRSRIVGRPISILMSRK 182 Query: 183 GC----TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 T T+TH T N+ ++ + AD++I AVG+PGF+ G IKEGAIVIDVGI +++NG Sbjct: 183 NYLGNSTVTLTHSQTPNIDYYTKQADIIITAVGRPGFLTGKMIKEGAIVIDVGITKVKNG 242 Query: 239 K---VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 K + GDV F +ASY+TPVPGGVGPMT LI+NTL A + Sbjct: 243 KKSFLKGDVDFNSVYGKASYLTPVPGGVGPMTRIMLIKNTLIAALN 288 >UniRef50_B8C1N0 5, 10-methylenetetrahydrofolate dehydrogenase n=1 Tax=Thalassiosira pseudonana RepID=B8C1N0_THAPS Length = 316 Score = 341 bits (875), Expect = 2e-92, Method: Composition-based stats. Identities = 130/316 (41%), Positives = 180/316 (56%), Gaps = 28/316 (8%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A+ IDGK+IA +RSE+A ++ + + PGLAV+LVGS SQ YV K+KAC + Sbjct: 1 MTAQDIDGKSIAATIRSELAAELSSLPSDSTSRPGLAVMLVGSRKDSQTYVRMKQKACSD 60 Query: 61 VGFVSRSYDLP--ETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDK 118 G VS + P E E LL+ I N D + GILVQLPLP I ++L+ + P K Sbjct: 61 CGMVSFLQEYPNGEEVEEEMLLKKIREWNEDEKVHGILVQLPLPEKISEERILKAVDPKK 120 Query: 119 DVDGFHPYNVGRLCQRA----------------PRLRPCTPRGIVTLLERY----NIDTF 158 DVDG HP N L + P PCTP+G + LL+R ++ Sbjct: 121 DVDGLHPANTASLFSTSTHAGAQKLNWKDFTSIPFHIPCTPQGCIELLDRINDGKGVEIE 180 Query: 159 GLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPG 218 G+NAVVIG SN+VG P++M LL T T+ H TKN+ + V+ AD+++ AVG+ +P Sbjct: 181 GMNAVVIGRSNLVGLPVAMLLLHRNATVTIVHSRTKNIENVVKQADIVVAAVGRANMVPA 240 Query: 219 DWIKEGAIVIDVGINRLENG------KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLI 272 W+K G VIDVGIN ++ ++VGDV + +A + +ITPVPGGVGP+T+A L+ Sbjct: 241 SWLKPGCTVIDVGINSVDAPDTKRGYRLVGDVNYAEAKEVCGWITPVPGGVGPLTIAMLL 300 Query: 273 ENTLQACVEYHDPQDE 288 NTL + E Sbjct: 301 RNTLNSWKRATGEGSE 316 >UniRef50_UPI0000DB7ABF PREDICTED: similar to Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor n=1 Tax=Apis mellifera RepID=UPI0000DB7ABF Length = 407 Score = 341 bits (874), Expect = 2e-92, Method: Composition-based stats. Identities = 129/299 (43%), Positives = 178/299 (59%), Gaps = 13/299 (4%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A IIDGK IA ++++E+ V I + P L + VG+NPAS+IYV K KA + Sbjct: 109 NAIIIDGKKIANKIQNELKITVDNWINDNKKRPKLVAIKVGNNPASKIYVEKKIKAANFI 168 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + + L E +S+ +++ ID LN D T+DGILVQLPL ++ +V + I P KDVD Sbjct: 169 GIENYTIHLDEKSSQQDIINEIDNLNKDKTVDGILVQLPLIKHMNEQEVCQAIIPSKDVD 228 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GFH N+G L + P T + L+ R NI+TFG NAVV+G S VG P+++ L Sbjct: 229 GFHLENLGNLALNRNGIIPATALAVKELIIRNNIETFGKNAVVVGRSKHVGLPIALLLHG 288 Query: 182 A--------GCTTTVTHRFTKN--LRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVG 231 TTT+ HR T + L + ADL++VA G PG I + IK GA +IDVG Sbjct: 289 DSKDRTGALDMTTTICHRHTPHTELEKFTKLADLVVVAAGIPGLITKEMIKPGACIIDVG 348 Query: 232 INRLE---NGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQD 287 I R++ K+VGDV FE+ A YITPVPGGVGPMTVA L++NT+ A + ++ + Sbjct: 349 ITRIKMDNKYKIVGDVDFENVKSIAGYITPVPGGVGPMTVAMLMKNTILAANKNYENSN 407 >UniRef50_A5V1H2 Methenyltetrahydrofolate cyclohydrolase n=7 Tax=Bacteria RepID=FOLD_ROSS1 Length = 288 Score = 341 bits (874), Expect = 2e-92, Method: Composition-based stats. Identities = 131/286 (45%), Positives = 176/286 (61%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A I+DG+ +A+ +R E+ QA I AP LAVV + +PAS Y + RK CEE Sbjct: 1 MTAIILDGRALAKTLREELRADTQAFIQNNGIAPSLAVVKIAGDPASDRYTRTIRKGCEE 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G + LP T++A L E I L+ D TI GIL+ LPLP G+D+ + + +I P KDV Sbjct: 61 IGITFTDHTLPPETTQAMLEETISALSFDRTIHGILLHLPLPPGLDSARAIAQIDPAKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG HPYN G L P L P TP G + LL R NI G +A V+G S +VG+PM++ LL Sbjct: 121 DGVHPYNAGLLAMGRPGLIPNTPAGGMELLLRNNIPLKGQHATVVGRSVVVGKPMALLLL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T T+ H TK+L V +AD+++ A GKPG I GD +K GA+V+D G+N LE+G+V Sbjct: 181 NEHATVTIAHSRTKDLAAVVRSADIVVAATGKPGLITGDMVKPGAVVVDFGVNVLEDGRV 240 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 VGDV F+ AS ITPVPGG GP+T L+ N L+A + + Sbjct: 241 VGDVDFDSVVNVASAITPVPGGTGPVTNVMLLRNVLRAAQQQLASR 286 >UniRef50_Q2GLF2 Methenyltetrahydrofolate cyclohydrolase n=41 Tax=Bacteria RepID=FOLD_ANAPZ Length = 304 Score = 340 bits (873), Expect = 3e-92, Method: Composition-based stats. Identities = 116/283 (40%), Positives = 169/283 (59%), Gaps = 4/283 (1%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 IIDGK A + + ++ P L V++VG +PAS++YV +K++ EE+G Sbjct: 7 NIIDGKAAAADLLGRLKVVMEGLKEEHGLFPSLVVIIVGDDPASRLYVGNKQRKAEELGI 66 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S++ LP T++ ELL +I LN D + GILVQLPLP ID + ++ I P+KDVDGF Sbjct: 67 NSKTIALPYETTQEELLGIIQELNEDENVHGILVQLPLPKHIDKILIINAIDPEKDVDGF 126 Query: 124 HPYNVGRLCQRA-PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 H N G+L + PCTP+G + L+++ AVVIG SNIVG+P+++ L+ Sbjct: 127 HNANAGKLLTGEMDCMVPCTPQGCIYLIKKVMPVLSSKRAVVIGRSNIVGKPVALLLMYE 186 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE---NGK 239 CT ++ H T N+ H +A+++I AVGK + +W+ GA+VIDVGIN + + Sbjct: 187 NCTVSILHSATANIEEHCRDAEIIIAAVGKARMVKSEWVSPGAVVIDVGINLITSESKNR 246 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 VGDV FE + + ITPVPGGVGPMT+A L+ NT+ Sbjct: 247 FVGDVDFESVRDKVAAITPVPGGVGPMTIAFLLVNTVLGACRQ 289 >UniRef50_A2BX55 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=cellular organisms RepID=FOLD_PROM5 Length = 298 Score = 340 bits (873), Expect = 3e-92, Method: Composition-based stats. Identities = 121/276 (43%), Positives = 178/276 (64%), Gaps = 5/276 (1%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 +DGK ++ ++ ++ + +++ I + R PGLAV+ +G +PAS +YV +K +AC VG S Sbjct: 5 LDGKKLSLEIEEKLKKDIESNINSTKRPPGLAVIRIGEDPASGVYVKNKERACARVGIKS 64 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 + L +T + E+ +LI+ LN DN IDG+L+QLP+P D +++ I+PDKDVDG + Sbjct: 65 FIFHLKDTIDQKEVEQLINKLNLDNDIDGMLLQLPIPDKFDEQRLISLINPDKDVDGLNE 124 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCT 185 N+G+L + P +R CTP GIV LL NI G VV+G S +VG+P+S+ LL T Sbjct: 125 KNIGKLVKNEPGMRSCTPAGIVNLLRSQNITIEGKKIVVVGRSLLVGKPLSLMLLNLNGT 184 Query: 186 TTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-----KV 240 T+TH T NL+ + AD+LI A GKP I ++K+GA++IDVGI+RL + K+ Sbjct: 185 VTITHSKTINLKKICKEADILIAAAGKPNLINSSYVKDGAVIIDVGIHRLTSSDKSQTKL 244 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 GDV+ ED + TPVPGGVGPMTV L+ NT+ Sbjct: 245 CGDVLLEDVIPKVYAYTPVPGGVGPMTVTMLLVNTI 280 >UniRef50_C8PLX3 Bifunctional protein FolD n=1 Tax=Treponema vincentii ATCC 35580 RepID=C8PLX3_9SPIO Length = 304 Score = 340 bits (872), Expect = 5e-92, Method: Composition-based stats. Identities = 135/288 (46%), Positives = 184/288 (63%), Gaps = 7/288 (2%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A+IIDGK +A+Q+ V ++ A + P LA+V G++PASQ+Y+ +K KA E+ Sbjct: 1 MAQIIDGKRLAEQLTQAVTRENAAYCTRHPQ-PCLAIVSSGTDPASQVYIKTKIKALEKA 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G SR +T SE EL + TLNAD+T+DGIL+QLPLP +D+ ++L + P KD+D Sbjct: 60 GMRSRIIPYSQTISEEELTACVQTLNADDTVDGILIQLPLPYPLDSRRILAPLAPHKDID 119 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GF P N+GRL P PCTP+GI+ L Y I G +AV++G S IVG+P++ L Sbjct: 120 GFTPENLGRLLTGRPGFIPCTPQGILYALREYGIPLSGAHAVIVGRSAIVGKPLAALLTA 179 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN---- 237 A T T+ H TK+L AD+LI A G PG I G IK+GA VIDVGINR+ + Sbjct: 180 ADATVTLCHSKTKDLAAITRQADILIAAAGHPGLITGSMIKKGAAVIDVGINRIPDPSAP 239 Query: 238 --GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 ++ GDV FE AA++A +ITPVPGGVGP+TVA ++ NTL+A H Sbjct: 240 KGSRLTGDVDFESAAEQAGWITPVPGGVGPLTVAMVLRNTLRAAQLRH 287 >UniRef50_C3K8G7 Putative histidine biosynthesis-related tetrahydrofolate dehydrogenase n=1 Tax=Pseudomonas fluorescens SBW25 RepID=C3K8G7_PSEFS Length = 314 Score = 339 bits (871), Expect = 6e-92, Method: Composition-based stats. Identities = 138/289 (47%), Positives = 182/289 (62%), Gaps = 4/289 (1%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A+ IDGK I+ +V EV ++V + + P LAV+LVG +PAS +YV +K ++VG Sbjct: 12 ARDIDGKAISARVLDEVREEVLLLASQQIY-PALAVLLVGDDPASHVYVRNKLLRAKDVG 70 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 S Y LPE S+ ++L+L+ LNAD +++GILVQLPLPA ID V+ I P KDVDG Sbjct: 71 IRSLEYRLPEDASQTQVLDLLAQLNADTSVNGILVQLPLPAQIDEAAVIHAIDPIKDVDG 130 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 FH NVG L Q L PCTP G + LL D GL+AVVIG SNIVG+PM+ LL A Sbjct: 131 FHRENVGGLVQGIEVLTPCTPSGCMRLLHETCGDLSGLHAVVIGRSNIVGKPMATLLLQA 190 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN---GK 239 C+ +V H + + AD+++ AVG+P I W+K GA+VIDVGINR+ + Sbjct: 191 NCSVSVVHSRSVDAPALCRLADIVVAAVGRPQLIDARWLKPGAVVIDVGINRITTETGTR 250 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQDE 288 +VGDV + A AS ITPVPGGVGPMT+A L++NTL A +E Sbjct: 251 LVGDVDYASARTVASAITPVPGGVGPMTIAYLLKNTLVASQLQRSKANE 299 >UniRef50_A8GNK0 Methenyltetrahydrofolate cyclohydrolase n=15 Tax=cellular organisms RepID=FOLD_RICAH Length = 295 Score = 339 bits (870), Expect = 7e-92, Method: Composition-based stats. Identities = 119/284 (41%), Positives = 171/284 (60%), Gaps = 7/284 (2%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 IIDGK +A ++ ++ ++Q + +P LA+VLVG NPAS IYV +K K ++G Sbjct: 3 NIIDGKALANEILEDLKLEIQELKSQTNASPKLAIVLVGDNPASIIYVKNKIKNAHKIGI 62 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + +L T +L+ I+ LN DN I G++VQLPLP ID K+L + P KDVDGF Sbjct: 63 DTLLVNLSTTIHTNDLITKINELNHDNEISGMIVQLPLPNSIDKNKILSAVSPYKDVDGF 122 Query: 124 HPYNVGRLCQR-------APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMS 176 HP NVG L + PCT G + ++++Y + G + VVIG SNIVG+P+S Sbjct: 123 HPLNVGYLHSGIIDVSEFSQSFIPCTALGCLAVIKKYEPNLSGKHVVVIGRSNIVGKPLS 182 Query: 177 MELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE 236 LL C+ T+ H T NL AD+++ A+G P + ++ +IVIDVGINR+ Sbjct: 183 ALLLKEDCSVTICHSKTHNLGSIALKADIVVAAIGSPLKLTAEYFNPESIVIDVGINRIS 242 Query: 237 NGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 K++GDV FE + YITPVPGG+GPMT+A L++NT++A Sbjct: 243 GNKIIGDVDFEHVKSKVKYITPVPGGIGPMTIAFLLKNTVKAFK 286 >UniRef50_B0S8U6 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=Bacteria RepID=FOLD_LEPBA Length = 291 Score = 339 bits (870), Expect = 7e-92, Method: Composition-based stats. Identities = 121/287 (42%), Positives = 177/287 (61%), Gaps = 4/287 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 ++ ++DGK I++++R+ + + + A G P LA +LVG+NPAS+ YV K KACE+V Sbjct: 3 SSILLDGKAISEKIRNRIQETLAKAKAEGKGIPTLATILVGNNPASETYVNMKVKACEKV 62 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G SR L E T+ ELL I LN D +I+GIL+Q P+P ID K + I +KDVD Sbjct: 63 GMHSRYIRLKEETTTEELLGEIRKLNLDPSINGILLQHPVPHQIDERKAFDEIALEKDVD 122 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G + G+L + PCTP G+V LL+ Y ID G +AVV+G S I+G+PM++ L Sbjct: 123 GVTTISFGKLSMNSEAYYPCTPYGMVLLLQEYGIDVTGKHAVVVGRSPILGKPMAIMLTN 182 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 T T+ H T++L V+ AD+++ AVGKP FI +W+KEG +++D G N V Sbjct: 183 LNATVTLCHSKTEDLPSLVKQADIIVGAVGKPEFIKAEWMKEGVVILDAGYNVGN----V 238 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQDE 288 GD+ A ++SY TPVPGGVGPMT++ L+ T+ + + P+ E Sbjct: 239 GDIEVSKAKDKSSYYTPVPGGVGPMTISVLLLQTMYSFLGQFSPKLE 285 >UniRef50_Q18GK1 Methenyltetrahydrofolate cyclohydrolase n=15 Tax=cellular organisms RepID=FOLD_HALWD Length = 311 Score = 339 bits (869), Expect = 8e-92, Method: Composition-based stats. Identities = 142/282 (50%), Positives = 178/282 (63%), Gaps = 8/282 (2%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 ++IDG +A +RS++ V RI P LA VL+ +PASQ YV+ K CEEVG Sbjct: 19 QLIDGTEVAASIRSDLISSV-TRIVNTGTTPQLATVLMNDDPASQTYVSMKHDDCEEVGI 77 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 +R + AEL + +D LNAD+++ GILVQ+PLP +D +VL RI P KDVDGF Sbjct: 78 ATRDITIDPEAPAAELFDTVDELNADSSVHGILVQMPLPDHVDEREVLRRIDPKKDVDGF 137 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA- 182 HP NVGRL PR +PCTP GI LL +I+T G NAVVIG SNIVG+PM+ L+ Sbjct: 138 HPENVGRLVAGQPRYKPCTPHGIQKLLIAADIETEGANAVVIGRSNIVGKPMANLLIQKA 197 Query: 183 ---GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN-- 237 T T H T NL +AD++I A G P I GD I G +VIDVGINR+E Sbjct: 198 DAGNATVTTCHSRTNNLASKTRDADIIIAAAGVPEMIDGDMISTGTVVIDVGINRVETEN 257 Query: 238 -GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 ++VGDV FE AAK+A ITPVPGGVGPMT A L+ NT++A Sbjct: 258 GSELVGDVEFESAAKKADAITPVPGGVGPMTRAMLLWNTVKA 299 >UniRef50_B1ZYH0 Methenyltetrahydrofolate cyclohydrolase n=8 Tax=root RepID=FOLD_OPITP Length = 293 Score = 339 bits (869), Expect = 1e-91, Method: Composition-based stats. Identities = 124/291 (42%), Positives = 172/291 (59%), Gaps = 14/291 (4%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 +IDG IA + +E+ +V A R P +A+V +G +PAS YV +K + E+G Sbjct: 3 LIDGSKIAATIVAELKAEVAALT---GRKPCIALVRIGEDPASVSYVKNKERTAAEIGLT 59 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 R P T S+AEL LID LNAD +DGILVQ P+P +D ++V RI P+KDVDG Sbjct: 60 GRVILPPVTISQAELFALIDGLNADAGVDGILVQAPMPKHLDELQVFRRIAPEKDVDGLG 119 Query: 125 PYNVGRLCQRAP-RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA- 182 N+G++ Q CTP GI+ LL R +D G + VV+G S +VG+P+++ L Sbjct: 120 TMNLGKVAQDDDTGFVSCTPAGIMELLSRSGVDLKGKHVVVVGRSLLVGKPVALLALQKK 179 Query: 183 ---GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG- 238 T T+ H TK+L AD+LI A+G+ GF+ D +K G +VIDVGINR+ + Sbjct: 180 AGANGTVTICHSATKDLPAITRQADVLIAAIGRAGFVTADMVKPGVVVIDVGINRVPDST 239 Query: 239 -----KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 ++VGDV F + AS ITPVPGGVGPMTVA L++NT++A Sbjct: 240 KKSGYRLVGDVDFPAVSPLASQITPVPGGVGPMTVAMLMKNTVKAYRLRQH 290 >UniRef50_C8P9U1 Putative uncharacterized protein folD2 n=1 Tax=Lactobacillus antri DSM 16041 RepID=C8P9U1_9LACO Length = 289 Score = 338 bits (867), Expect = 1e-91, Method: Composition-based stats. Identities = 125/282 (44%), Positives = 174/282 (61%), Gaps = 3/282 (1%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 IIDGK IA+++ ++ Q+V A A L PG+AV++VG +PASQIY +K + +++G Sbjct: 2 IIDGKKIAREINAKTRQQVAALKAHQL-TPGIAVIVVGDDPASQIYTRTKHRLAQKLGIA 60 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S Y P +A +L+ + LN D+++D ILVQ PLPA ++ +++ I P KD DG H Sbjct: 61 STRYHFPADVDQATVLQQVRKLNRDDSVDAILVQAPLPAQLNGEEIVNAIDPAKDADGLH 120 Query: 125 PYNVGRLCQRAPRLRP--CTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 P N+GRL + P CTPRGI+TLL++Y + G N V++G S +VG+P+ L Sbjct: 121 PLNLGRLYAKQGGHYPVACTPRGIMTLLKQYQVPLAGANVVIVGRSLLVGKPLLALLNNQ 180 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T T R TK AD+LIVA G PG + +K GA+VIDVGINRL +GK+VG Sbjct: 181 NATVTFVGRHTKKRATLTRQADILIVAAGVPGLVKAGDVKAGAVVIDVGINRLPSGKLVG 240 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 DV F A A ITPVPGGVGP+TVA L+ T++ + Sbjct: 241 DVDFAGVASLARLITPVPGGVGPLTVAMLMRQTVELAEWRRE 282 >UniRef50_Q2SRE7 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=Mollicutes RepID=FOLD_MYCCT Length = 284 Score = 337 bits (865), Expect = 3e-91, Method: Composition-based stats. Identities = 123/279 (44%), Positives = 178/279 (63%), Gaps = 1/279 (0%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+DGK +++ + V Q++ + G R P LAV+L+G++ AS++YV++K KAC VG Sbjct: 3 ILDGKLVSKTRKQLVKQQIDIYLNKGYRKPKLAVILIGNDQASELYVSNKIKACNLVGIE 62 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S E + L + I+ LN D +D IL+QLPLP ++ L+ I P KDVDGFH Sbjct: 63 SMLLRFDENINSQTLSDQINQLNNDQLVDAILLQLPLPKHLNEQMFLQAITPLKDVDGFH 122 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 N G++ + + PCTP GI+ LL+ YN+D + +IG SNIVG+P+++ L G Sbjct: 123 YINQGKMLEGYDTIYPCTPIGIINLLKAYNVDVKSKDITIIGTSNIVGKPLAIMLSNMGA 182 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE-NGKVVGD 243 T ++ ++ TK+L+ + + +D++I A GK I D IK+ AIVIDVGI R K+VGD Sbjct: 183 TVSMCNKNTKSLKKYTKISDIVISATGKQFIITKDMIKKNAIVIDVGIIRDPITNKIVGD 242 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 V FE+ + SYITPVPGGVGPMTVA L+ENTLQ ++ Sbjct: 243 VDFENVKELCSYITPVPGGVGPMTVAMLLENTLQLYKKH 281 >UniRef50_UPI00016C0DE6 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016C0DE6 Length = 282 Score = 337 bits (865), Expect = 3e-91, Method: Composition-based stats. Identities = 127/277 (45%), Positives = 174/277 (62%), Gaps = 3/277 (1%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 K IDG IA ++ EV V+A + GL+V+ V +N ++QIY+ +K+KAC+ VG Sbjct: 6 KKIDGTKIASIIKQEVKDAVEAMAPETV---GLSVITVQTNSSAQIYIKNKQKACDYVGI 62 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S+ Y L E+++ +LELI+ LN +++DGILVQLPLP +D ++ I P KDVDGF Sbjct: 63 KSQIYTLDESSTTNNVLELIEVLNDSHSVDGILVQLPLPKHMDQSTIIAAISPSKDVDGF 122 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 N+ L CTP GI+ LL+ NI+ G V+IG SNIVG+P+++ LL Sbjct: 123 SKENLAGLIAGGSSFESCTPLGIMALLKHENIEIAGKKCVIIGRSNIVGKPLALMLLNED 182 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T + H T NL + ++ AD+LI AVGK FI G IK A+VIDVGI ENGK+ GD Sbjct: 183 ATVCICHSKTVNLANEIKTADILISAVGKAKFITGAMIKPKAVVIDVGITHDENGKLCGD 242 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 V F+ A YITPVPGGVGPMT+A L++N ++A Sbjct: 243 VDFDSCLGIAEYITPVPGGVGPMTIAMLLKNCVRAAQ 279 >UniRef50_Q03RR1 Methenyltetrahydrofolate cyclohydrolase n=22 Tax=Bacteria RepID=FOLD_LACBA Length = 288 Score = 337 bits (864), Expect = 4e-91, Method: Composition-based stats. Identities = 137/278 (49%), Positives = 180/278 (64%), Gaps = 3/278 (1%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 IIDGK IA+ + ++ A +V A + PGLAV++VG +PAS IYV +K K ++G Sbjct: 4 IIDGKQIAKDLNAQTATRVAALKKRDI-VPGLAVIVVGDDPASAIYVRNKHKKALKLGIK 62 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S +LP TT++AEL +++ N D TI GILVQ PLPAG+D ++ I P KDVDGFH Sbjct: 63 SVVRELPATTTQAELTQIVMAYNVDPTIHGILVQSPLPAGLDEQAIVAAIDPQKDVDGFH 122 Query: 125 PYNVGRLCQRAPRLRP--CTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 P NVGRL P P CTPRGI+T+L + G AVV+G S IVGRPM+ LL A Sbjct: 123 PLNVGRLFANLPGKYPVSCTPRGIMTMLATLPMHLRGKRAVVVGRSLIVGRPMAAMLLNA 182 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T +V H T++L AD+L+VA G I +K GA+VIDVG++R ENGK+ G Sbjct: 183 DMTVSVAHVHTQHLSDLTRTADVLVVATGVTHLIKATDVKPGAVVIDVGMDRDENGKLTG 242 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 DV F++ A R + ITPVPGGVGPMT+ATL++ T+ C Sbjct: 243 DVDFDNVAPRVAAITPVPGGVGPMTIATLMQQTVDLCE 280 >UniRef50_A9HEL1 Methenyltetrahydrofolate cyclohydrolase n=82 Tax=cellular organisms RepID=FOLD_GLUDA Length = 311 Score = 336 bits (862), Expect = 6e-91, Method: Composition-based stats. Identities = 146/284 (51%), Positives = 179/284 (63%), Gaps = 4/284 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A++IDGK A + +A+ VQ+ PGLAVVLVG++PAS++YV +K Sbjct: 20 TARLIDGKAFAANLTQTIARDVQSFHDRYRVTPGLAVVLVGNDPASEVYVRNKALQTHRA 79 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S + LP TTS+AELL LI LNAD I GILVQLPLPAG+D V V I PDKDVD Sbjct: 80 GMRSFMHMLPATTSQAELLALIGRLNADPEIHGILVQLPLPAGLDPVAVTNAILPDKDVD 139 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G N GRL P + PCTP G + LL+ D GL+AV+IGASN+VGRPM+ LL Sbjct: 140 GLGEVNAGRLALGQPGIVPCTPLGCLMLLKSELGDLRGLHAVIIGASNLVGRPMARLLLA 199 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE----N 237 GCT TV H T++ D+L+VA G G + GDWIK GA VIDVGI R+ Sbjct: 200 EGCTVTVGHIDTRDPAALARQGDILVVATGCHGLVRGDWIKPGAAVIDVGITRISLPSGK 259 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 ++VGDV F++A RA ITPVPGGVGPMT+A L+ NTL A Sbjct: 260 TRLVGDVAFDEAVTRAGCITPVPGGVGPMTIACLLNNTLAAARR 303 >UniRef50_C1XHV3 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); methenyltetrahydrofolate cyclohydrolase n=2 Tax=Bacteria RepID=C1XHV3_MEIRU Length = 293 Score = 336 bits (862), Expect = 6e-91, Method: Composition-based stats. Identities = 121/283 (42%), Positives = 165/283 (58%), Gaps = 10/283 (3%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 + G +A+ V E+ Q +A P L VV +G +PAS YV K + + +G S Sbjct: 4 LSGPPVAEAVYQEL----QTLLATLPYVPHLRVVRLGDDPASVAYVRLKDRQAKRLGLSS 59 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 + PE+TS+ ELL I LNAD +DGILVQ P+P +D VLE I P KDVDG P Sbjct: 60 QVDVFPESTSQEELLAHIARLNADPEVDGILVQSPVPRQVDFNAVLEAIDPLKDVDGLTP 119 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCT 185 N GR+ L CTP G++ LL+ Y I G V++G SN+VG+P++ +L T Sbjct: 120 VNAGRMWMGLEALESCTPAGVMRLLKHYQIPLAGKEVVIVGRSNLVGKPLAALMLREHAT 179 Query: 186 TTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL---ENGK--V 240 T+ H T++L AD+L+ AVGK G I + ++ GA+V+DVGINR+ E G+ + Sbjct: 180 VTLAHSRTQDLAAVCRRADVLVAAVGKAGLITPEMVRPGAVVVDVGINRVGQNEKGRDIL 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 VGDV A AS +TPVPGGVGPMTVA L+ NT+ A + Sbjct: 240 VGDVA-PGVAAVASALTPVPGGVGPMTVAMLLYNTVIAAMRRR 281 >UniRef50_A8ZTQ4 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=Bacteria RepID=FOLD_DESOH Length = 303 Score = 335 bits (861), Expect = 7e-91, Method: Composition-based stats. Identities = 136/295 (46%), Positives = 175/295 (59%), Gaps = 17/295 (5%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M+AK+I G I +++ E+ +V+ + PGL +LVG +PAS YV K + Sbjct: 1 MSAKLIKGTEIREEILKEIEAEVKEIKEKHGKVPGLVTILVGESPASISYVTLKIQTAHR 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VGF P SEA+LL LID N D++I GILVQLPLP ID KVL I PDKDV Sbjct: 61 VGFKEVQDSQPVDISEADLLALIDKYNKDDSIHGILVQLPLPKHIDEKKVLNAIDPDKDV 120 Query: 121 DGFHPYNVGRLCQRAP--RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSME 178 DGFHP NVGRL + PCTP GI ++ R ++T G VV+G SNIVG+P++ Sbjct: 121 DGFHPVNVGRLMIGGSEVKFPPCTPAGIQEMIVRAGVETSGAEVVVVGRSNIVGKPIANM 180 Query: 179 LLLAG----CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINR 234 +L G T TV H TKN+ H + AD+LIVA G PG + +WIK GA VIDVG+NR Sbjct: 181 MLQKGPGANATVTVVHTRTKNMDEHCKRADILIVAAGVPGLVKPEWIKPGACVIDVGVNR 240 Query: 235 LENGK-----------VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 + + GDV F+ A + A ITPVPGGVGPMT+ L+ NTL++ Sbjct: 241 VGEKPSAKDPNKMVAILSGDVDFDAAKEIAGSITPVPGGVGPMTITMLMLNTLKS 295 >UniRef50_D1AX33 Methylenetetrahydrofolate dehydrogenase (NADP(+)) n=1 Tax=Streptobacillus moniliformis DSM 12112 RepID=D1AX33_STRM9 Length = 285 Score = 335 bits (861), Expect = 8e-91, Method: Composition-based stats. Identities = 123/282 (43%), Positives = 180/282 (63%), Gaps = 3/282 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M ++DG+ ++ + ++ + Q I + GLA + VG++ AS IY+ +K K C+E Sbjct: 1 MIKSMLDGRYVSNILYEKLKIEYQILIDKIGKRAGLAFIKVGNDRASTIYLKNKAKKCDE 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G ++ E +E EL+ I+ LN D IDGIL+QLPLP+ I+ + V+ I+P KDV Sbjct: 61 LGIYQKTIIFEENITETELISEINKLNDDKNIDGILLQLPLPSHINYISVMSTINPKKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP NVG L + + CTP+GI+ LL YNI + V+IG SNIVG+P+++ L+ Sbjct: 121 DGFHPENVGNLLFKDKGIYSCTPQGIMELLNYYNISIESKDIVIIGRSNIVGKPLALMLI 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 G T V + TK+L + + AD+LI A G I ++IK+GA+VIDVGI+ E GK+ Sbjct: 181 NEGATVQVCNSKTKDLFNKTKQADILISATGVSHLIKSEYIKDGAVVIDVGISEFE-GKI 239 Query: 241 VGDVVFEDAAK--RASYITPVPGGVGPMTVATLIENTLQACV 280 +GDV FED + YITPVPGGVGPMT+ +LI+NT++A Sbjct: 240 IGDVDFEDVIQNSNVRYITPVPGGVGPMTIYSLIKNTIRAFE 281 >UniRef50_C5R8B8 Bifunctional protein: methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase n=1 Tax=Weissella paramesenteroides ATCC 33313 RepID=C5R8B8_WEIPA Length = 303 Score = 334 bits (858), Expect = 1e-90, Method: Composition-based stats. Identities = 144/291 (49%), Positives = 192/291 (65%), Gaps = 5/291 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 AKIIDGK IA+++RS V+++ + PGLAV+LVG +PAS+IYV +K +A ++V Sbjct: 8 MAKIIDGKEIAKKLRSAVSEQAAILKEQSV-IPGLAVILVGDDPASEIYVRNKERAAKKV 66 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + ++ P T +E E+L+ + LNAD+TID ILVQ P+P+ I+ KV E I P KDVD Sbjct: 67 GVHAVTFKYPSTATEKEILDKVAELNADDTIDAILVQSPVPSQINEQKVQEAIIPSKDVD 126 Query: 122 GFHPYNVGRLCQRAPRLRP--CTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 GFHP NVGRL P TPRGI+T+L+ ID +AVVIG S +VGRPM L Sbjct: 127 GFHPENVGRLYANQAGYYPIANTPRGIMTMLQHEKIDLLNKHAVVIGRSILVGRPMFALL 186 Query: 180 LLAGCTTTVTHRFTKN--LRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 A + T+ HR+T R + AD+++VA G P + G +K GA+VIDVGINRL N Sbjct: 187 QAADTSVTLLHRYTPAALRRELLATADVVVVATGVPDLVMGADLKPGAVVIDVGINRLPN 246 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQDE 288 K+VGDV F A K AS ITPVPGGVGPMT+ATL++ T++ E+H + E Sbjct: 247 NKLVGDVNFGTAEKVASAITPVPGGVGPMTIATLLQTTVELAAEHHQIELE 297 >UniRef50_Q14NV1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Spiroplasma citri RepID=FOLD_SPICI Length = 286 Score = 333 bits (854), Expect = 5e-90, Method: Composition-based stats. Identities = 122/273 (44%), Positives = 176/273 (64%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 KIIDGK +++ +++++ +++ A R P L ++ +G+N AS Y+ +K+ ACE+VG Sbjct: 5 KIIDGKMVSELIKAKITEQILKIKAKKQRVPALTIIQIGNNKASTTYIKNKKIACEKVGV 64 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + + P+ +E+ L+++I+ LN ++ ID ILVQLPLP+ I++ KV+ I KDVDGF Sbjct: 65 TCKVLNYPDIITESALIKIINDLNNNSKIDAILVQLPLPSHINSEKVINTIITKKDVDGF 124 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 P +G L L P TP+GI+ LL+ Y I G + V+IG SNIVG+P++ L+ A Sbjct: 125 TPKILGNLMLGHYNLLPSTPKGIIALLKHYQIQLAGQHVVIIGRSNIVGKPLANLLINAS 184 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T TV H TKNL AD+LI AVGK F+ + IKE IVIDVGINR E+ + GD Sbjct: 185 ATVTVCHSQTKNLSDFTNQADILISAVGKAKFVTAEMIKENVIVIDVGINRDEDNNLCGD 244 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 + F + + ITPVPGGVGPMT+A L+EN L Sbjct: 245 IDFHNVFSKVKMITPVPGGVGPMTIAALLENIL 277 >UniRef50_D0N1V3 Bifunctional folD protein n=1 Tax=Phytophthora infestans T30-4 RepID=D0N1V3_PHYIN Length = 308 Score = 331 bits (849), Expect = 2e-89, Method: Composition-based stats. Identities = 128/302 (42%), Positives = 173/302 (57%), Gaps = 19/302 (6%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 + ++DGK + + +++ + R+ GLAV++VGS S YV K+KAC V Sbjct: 6 SPILLDGKATSDAICTQLQPQCVDFKQRYGRSVGLAVMVVGSRKDSATYVRMKQKACTAV 65 Query: 62 GFVSRSY-----DLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHP 116 G S D P+ + +ELL +I LN +DGI+VQLPLP+ D +L I P Sbjct: 66 GITSWKIAIALDDKPQESVTSELLAIIKQLNNREDVDGIIVQLPLPSFCDESAILATIAP 125 Query: 117 DKDVDGFHPYNVGRLCQRA-------PRL-RPCTPRGIVTLLERYNIDTFGLNAVVIGAS 168 +KDVDG HP + +L Q A P PCTP G + LL+ Y I G + VV+G S Sbjct: 126 NKDVDGLHPESHAKLFQYATTKAQLVPSFALPCTPAGCLELLDHYKIPLEGKHVVVMGRS 185 Query: 169 NIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVI 228 IVG P+S+ L T T+ H T++L+ V AD++I A+G+P F+ GDWIK GA VI Sbjct: 186 QIVGLPVSLLCLHRNATVTMCHSHTRDLKARVLEADIVIAAIGRPCFVQGDWIKPGATVI 245 Query: 229 DVGINRLENG------KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 DVGIN LE+ ++VGDV F A K ITPVPGGVGPMTVA L++NTLQ + Sbjct: 246 DVGINPLEDATKKSGYRLVGDVDFNAAVKVVHAITPVPGGVGPMTVAMLLKNTLQCAIRR 305 Query: 283 HD 284 Sbjct: 306 AQ 307 >UniRef50_C8PD95 Putative uncharacterized protein folD n=1 Tax=Lactobacillus iners DSM 13335 RepID=C8PD95_9LACO Length = 301 Score = 330 bits (846), Expect = 5e-89, Method: Composition-based stats. Identities = 115/280 (41%), Positives = 173/280 (61%), Gaps = 2/280 (0%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+DGK A+++ E+ +V+ A + P V+ VG +PAS+IY+ KRK +++G Sbjct: 21 ILDGKEPAKKIIDELTLEVEHLKAKNI-LPTFCVIEVGEDPASKIYLRLKRKLAKKIGIN 79 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 ++ P + EL++ I LNAD +D I+VQLP+P I+ VLE I P KD DGF Sbjct: 80 EQTIKFPGDIRQDELIDKIKELNADPHVDAIMVQLPIPEHINTRLVLEAIDPTKDADGFT 139 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 PYN GR+ Q + P T R I+T+L+ Y ++ G NA++IG S IVG+P++ +LL Sbjct: 140 PYNQGRMWQGQVNIIPATVRSIMTILDYYQLNVEGKNALIIGRSIIVGKPVASQLLARNA 199 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+ H T+NL+ D++I VG+ I + +K G+I+IDVG+NR ENGK++GD+ Sbjct: 200 TVTIAHSHTRNLQELTLLNDIIISDVGRAHLITKNMVKPGSILIDVGMNR-ENGKLMGDI 258 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 ++D A ITPVPGGVGP+TVA L++ + H+ Sbjct: 259 EYDDCLPIAEAITPVPGGVGPLTVANLMKQVIILTKLRHN 298 >UniRef50_A6LU44 Methenyltetrahydrofolate cyclohydrolase n=22 Tax=Clostridium RepID=FOLD_CLOB8 Length = 282 Score = 329 bits (845), Expect = 6e-89, Method: Composition-based stats. Identities = 117/280 (41%), Positives = 172/280 (61%), Gaps = 1/280 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 +II+GK +A +V+ E+ V R L+ P +A +LVG++ S Y+ S+ K + Sbjct: 1 MGQIINGKEVALKVKEEIKNFVNNRKEKNLQVPKIASILVGNDGGSIYYMGSQEKVANSL 60 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G LPET ++ +++ I+ LN DN I GI++QLPLP D K++++I P+KD+D Sbjct: 61 GVEFLKLTLPETCNDEDVIAEINKLNEDNNIHGIILQLPLPNNFDEKKIIKQISPNKDID 120 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 + G+L P+ PCTP ++TL++ NID G N VV+G SNIVG+P++ LL Sbjct: 121 CLTFESQGKLYMGEPKFLPCTPNSVITLIKSLNIDIVGKNVVVLGRSNIVGKPVAQLLLN 180 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 T T+ H TKNLR +NAD+L+VA+G+P FI ++ E AIVIDVG + E GK+ Sbjct: 181 ENATVTICHSKTKNLREVCKNADILVVAIGRPKFIDETYVNENAIVIDVGTSSFE-GKIT 239 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 GDV F+ + Y+TPVPGGVG +T LI+N +A E Sbjct: 240 GDVDFDKVIDKCRYLTPVPGGVGSLTTTLLIKNACEALQE 279 >UniRef50_A8IFV5 5,10-methylenetetrahydrofolate dehydrogenase (Fragment) n=1 Tax=Chlamydomonas reinhardtii RepID=A8IFV5_CHLRE Length = 301 Score = 329 bits (843), Expect = 1e-88, Method: Composition-based stats. Identities = 124/293 (42%), Positives = 174/293 (59%), Gaps = 15/293 (5%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A I+DG+ +A E+ V R PGL VVLVGS P S +YV K++AC++ G Sbjct: 1 AVILDGRAVAAAWERELVGDVARLTELLGRPPGLGVVLVGSRPDSMLYVTKKQEACQKAG 60 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 + + LP+T S+++L + + AD +DG+L+QLPLP + V+E + P KDVDG Sbjct: 61 MNTYVHHLPDTVSQSQLEAALAHVCADGRVDGVLIQLPLPRHLSEEAVMEVLDPRKDVDG 120 Query: 123 FHPYNVGRLCQRAPR--LRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 FHP N+GR+ R L P TP G + LL R +D G N VV+G SNIVG P++ L Sbjct: 121 FHPLNMGRMLMRGRGVRLVPATPLGCIELLRRSGVDVQGKNCVVLGDSNIVGTPLAAMLR 180 Query: 181 LAG-CTTTVTHRF-------TKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGI 232 G T+ HR + L +AD+L+VAVG P + GDW++ GA+VIDVGI Sbjct: 181 DKGAAAVTICHRRSYRECFQSYQLPDLTRSADILVVAVGHPELVRGDWVRPGAVVIDVGI 240 Query: 233 NRLEN-----GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 N + +VVGDV F++ ++ A ITPVPGG+GPMT+A ++ NTL+A Sbjct: 241 NVVSTLPRSPPRVVGDVAFDEVSRVAGAITPVPGGIGPMTIAAVLHNTLKAAK 293 >UniRef50_Q4T2B9 Chromosome undetermined SCAF10300, whole genome shotgun sequence n=10 Tax=cellular organisms RepID=Q4T2B9_TETNG Length = 348 Score = 327 bits (838), Expect = 4e-88, Method: Composition-based stats. Identities = 111/317 (35%), Positives = 165/317 (52%), Gaps = 37/317 (11%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAA-GLRAPGLAVVL--------------------- 40 A II G ++ +R + V+ + P L ++ Sbjct: 24 ATIISGNKTSRLLRDRLKADVEEMKSLFSGFRPALVILQPWAELLGQKLLRLLVLTSVFL 83 Query: 41 -----VGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGI 95 VG S +Y+++K KA E+G ++ LP + ++ E+L I ++N D ++ G+ Sbjct: 84 VTLLQVGDRDDSNLYISAKMKAAAEIGIDAKHVRLPSSATQEEVLLNILSINEDQSVHGL 143 Query: 96 LVQLPLPA--GIDNVKVLERIHPDKDVDGFHPYNVGRLCQRA--PRLRPCTPRGIVTLLE 151 +VQLPL + ID+ + + DKDVDG N GRL + PCTP G + L+ Sbjct: 144 IVQLPLDSVHHIDSECITNTVSADKDVDGLSCINAGRLSRGDLDACFLPCTPSGCLELIR 203 Query: 152 RYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVG 211 + + G AVVIG S IVG PM LL T T H T +L V AD+L+V G Sbjct: 204 QTGVSLEGKQAVVIGRSKIVGAPMHDLLLWNHATVTTCHSKTPDLPEQVGRADILVVGAG 263 Query: 212 KPGFIPGDWIKEGAIVIDVGINRLEN------GKVVGDVVFEDAAKRASYITPVPGGVGP 265 + + G+W+KEGA+VID GIN++ + +VVGDV + A +RA +ITPVPGGVGP Sbjct: 264 RAEMVRGEWLKEGAVVIDCGINQVPDCTRASGKRVVGDVHYASAHQRAGFITPVPGGVGP 323 Query: 266 MTVATLIENTLQACVEY 282 MTVA L++NT+++ Y Sbjct: 324 MTVAMLMQNTVRSAQRY 340 >UniRef50_Q189R8 Methenyltetrahydrofolate cyclohydrolase n=26 Tax=Bacteria RepID=FOLD_CLOD6 Length = 290 Score = 326 bits (836), Expect = 6e-88, Method: Composition-based stats. Identities = 98/283 (34%), Positives = 156/283 (55%), Gaps = 2/283 (0%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 +II GK +A ++ E+ ++V + G+ P L +V VG+ Y K C+ +G Sbjct: 8 GQIIKGKPVADKISEELIKEVDLLVKEGIN-PKLTIVRVGARSDDLSYERGALKRCQNIG 66 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 + +L E ++ E ++++ +N D ++GIL PLP ++ + I P+KDVD Sbjct: 67 ITTEVLELAEDITQEEYIDVLKRVNDDKNVNGILCFRPLPKHLNEEVIKYVIAPEKDVDC 126 Query: 123 FHPYNVGRLCQR-APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 F P N ++ + PCTP +V +L+ YN+D G V+G S +VG+P+SM LL Sbjct: 127 FSPINSAKVMEGDKSGFPPCTPTAVVEILKHYNVDLKGSKVTVLGRSMVVGKPVSMLLLS 186 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 T T+ H TKNL AD+LI A+G+ + ++K+GA+VIDVGIN E G + Sbjct: 187 EHATVTICHSKTKNLSGVAAEADVLIAAIGRAKMVDESFVKDGAVVIDVGINVDEEGNLC 246 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 GDV + S ITPVP GVG +T + L ++ ++AC ++ Sbjct: 247 GDVDTNAVLDKVSMITPVPAGVGSVTTSILAKHVVKACKLQNN 289 >UniRef50_Q254F7 Methenyltetrahydrofolate cyclohydrolase n=13 Tax=Chlamydiaceae RepID=FOLD_CHLFF Length = 287 Score = 324 bits (830), Expect = 3e-87, Method: Composition-based stats. Identities = 111/287 (38%), Positives = 175/287 (60%), Gaps = 14/287 (4%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 ++ G +A+++ ++ QK+ + PGLAVVL+G++PAS++YV K K +G V Sbjct: 2 LLKGTPVAERILEKLKQKI----SQSPTPPGLAVVLIGNDPASEVYVGMKVKKAMNLGMV 57 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S+++ LP + ++L+LI+ LN D TI GILVQ+PLP +D+ +++ I P+KDVDG H Sbjct: 58 SKAHRLPSDATLTDILKLIERLNNDPTIHGILVQIPLPKHLDSNVIIQAISPEKDVDGLH 117 Query: 125 PYNV-GRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA- 182 P N+ L + PCTP ++ LL Y+I G + V+G SNIVG+P++ L+ Sbjct: 118 PVNMGKLLLGQLGGFSPCTPAAVIELLNYYDIPLQGRHVAVVGRSNIVGKPLAAMLMQKH 177 Query: 183 ---GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGK 239 T T+ H ++N ++ AD+++ AVG P FI + I A+++DVGI+R+ Sbjct: 178 PTTNATVTLLHSQSQNFTEILKTADIIVAAVGVPLFIQENMISPNAVIVDVGISRVATNN 237 Query: 240 -----VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 +VGDV F + + ITPVPGGVGPMTVA L++NT ++ + Sbjct: 238 DKGYMLVGDVDFNNVVTKCKAITPVPGGVGPMTVAMLMKNTWESYQK 284 >UniRef50_C5C958 Methenyltetrahydrofolate cyclohydrolase n=118 Tax=Actinobacteria (class) RepID=FOLD_MICLC Length = 303 Score = 323 bits (828), Expect = 5e-87, Method: Composition-based stats. Identities = 118/297 (39%), Positives = 168/297 (56%), Gaps = 12/297 (4%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M AK++DGK A ++ E+ +V A G R PGL +LVG + SQ YVA K + C E Sbjct: 1 MTAKVLDGKATAAAIKEELRGRVAALAERG-RTPGLGTLLVGEDAGSQKYVAGKHRDCAE 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG S +LP +E ++L+++ LN D G +VQLPLP +D KVLE I PDKD Sbjct: 60 VGIESIQRELPADATEEQILDVVRELNEDPACTGYIVQLPLPKHVDTQKVLEAIDPDKDA 119 Query: 121 DGFHPYNVGRLCQ----RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMS 176 DG HP N+GRL PCTP G V LL + ++ G + +VIG +GRP Sbjct: 120 DGLHPMNLGRLVASVGGELDSPLPCTPAGCVELLRHHGVELAGKHVLVIGRGVTIGRPAG 179 Query: 177 MELLLA--GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINR 234 + L T T+ H T NL + +AD++I A G + + +KEG IV+DVG++R Sbjct: 180 LVLTRREVNATVTLAHTGTTNLDELLASADVVIAAAGSAHMVTPEQVKEGVIVLDVGVSR 239 Query: 235 L--ENGK--VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQD 287 + E+GK V+GDV ++A+++ P PGGVGPMT L+ N ++A D ++ Sbjct: 240 VTGEDGKSRVLGDVD-PAVKEKAAWMAPNPGGVGPMTRVMLLANVVEAAERAADGEN 295 >UniRef50_A5N5B5 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=Clostridiales RepID=FOLD_CLOK5 Length = 284 Score = 322 bits (827), Expect = 6e-87, Method: Composition-based stats. Identities = 104/280 (37%), Positives = 155/280 (55%), Gaps = 2/280 (0%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 II GK +A + + ++V G+ P L ++ VG+ + Y K C +G Sbjct: 4 IIKGKPVADAISETLIKEVDNFKIQGI-IPKLVIIRVGAKASDLAYEKGILKRCNGIGIE 62 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + + PE S+ E + + LN D +DGI+V PLP +D + I P+KD+D F+ Sbjct: 63 TYVKEFPEDISQREFIRELRRLNEDRNVDGIMVFRPLPKHLDENIIKYVITPEKDIDCFN 122 Query: 125 PYNVGR-LCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 P N+ + + + PCTPR ++ +L+ YNID G +VVIG S IVG+PMSM LL Sbjct: 123 PINLAKVIAGDSTGFAPCTPRAVMEILKYYNIDVEGKFSVVIGRSMIVGKPMSMLLLNEN 182 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T T H T +L AD+L+ +GK FI +IKEGA+VIDVGIN + GK+ GD Sbjct: 183 STVTTCHSKTVHLDKICSQADILVAGIGKAEFIDSKYIKEGAVVIDVGINVDKYGKLCGD 242 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 V + + +TPVPGGVG +T + L ++ ++AC + Sbjct: 243 VDIKSCQWKNVIVTPVPGGVGTVTSSVLAQHVVEACKHKN 282 >UniRef50_C8W0Y6 Methylenetetrahydrofolate dehydrogenase (NADP(+)) n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8W0Y6_DESAS Length = 287 Score = 322 bits (827), Expect = 7e-87, Method: Composition-based stats. Identities = 128/281 (45%), Positives = 187/281 (66%), Gaps = 5/281 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 MAA+++ GK IA +++ EV+ +V+A A G+ P L + VG N AS +Y +++K E Sbjct: 1 MAAELLKGKPIADKIKVEVSAEVEALKAKGV-TPFLVAIQVGENAASAVYTGAQKKVAES 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G +LP T++ EL++ I+ LNAD+ + GI++Q+PLPA ID +I KDV Sbjct: 60 LGIRYELRELPAETTQEELIKYIEGLNADDEVKGIILQMPLPAQIDARAAQWKIAYSKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 +G P+NVG + APRL PCTP G V L++ +D +G VV+G S+IVG+P +M LL Sbjct: 120 EGMTPHNVGLVTYFAPRLAPCTPAGAVELIKSTGVDLYGKEVVVVGHSDIVGKPTAMLLL 179 Query: 181 LAGCTTTVTHRFTKN---LRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 CT T+ H T HV NA++++VAVG PG + G+WIKEGAIVID+GIN++ + Sbjct: 180 KEFCTVTICHIATGQRGLTAQHVGNAEIVVVAVGVPGIVKGEWIKEGAIVIDIGINKVGD 239 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 K+VGDV FE A+++A+YITPVPGG G T A L++N ++A Sbjct: 240 -KIVGDVEFEAASEKAAYITPVPGGAGVATTAMLMKNLVEA 279 >UniRef50_D0N1T3 Bifunctional folD protein n=1 Tax=Phytophthora infestans T30-4 RepID=D0N1T3_PHYIN Length = 298 Score = 322 bits (825), Expect = 1e-86, Method: Composition-based stats. Identities = 118/295 (40%), Positives = 177/295 (60%), Gaps = 21/295 (7%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 AK++DGK ++++ +E+ + V P LA++LVG++ S+ YV K+ AC V Sbjct: 1 MAKLLDGKACSKEIEAELKELVPTL----NVTPTLALLLVGTDQDSKTYVRLKKNACTRV 56 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLE--RIHPDKD 119 G + ++L E+ AELL LI +LNADN++ GIL+QLPLP + + + P KD Sbjct: 57 GITPQVHELAESIEFAELLALIQSLNADNSVHGILLQLPLPDHLKLHEEELLEAVSPLKD 116 Query: 120 VDGFHPYNVGRLCQRAPR---------LRPCTPRGIVTLLERYNIDTFGLNAVVIGASNI 170 VDG H ++ RL + L+PCTP G + +L R I+ G + VVIG + Sbjct: 117 VDGLHSHHFARLAEPEKEEEGAVKTLQLQPCTPAGCLEILARNGIELAGKDVVVIGRGQL 176 Query: 171 VGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDV 230 VG P+S+ LL A T T H TKNL V A+++ V G+P + GDW+ EGA+V+DV Sbjct: 177 VGLPLSLMLLAANATVTTCHSKTKNLADKVRQAEVVFVGTGQPELVKGDWLAEGAVVVDV 236 Query: 231 GINRLENG------KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 GI+ +++ K++GDV F A++R S ITPVPGG+GPMT+A L++NT++ Sbjct: 237 GISYVDDASSKKGYKILGDVDFAAASERVSAITPVPGGIGPMTIAMLLKNTVECA 291 >UniRef50_C0GE27 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GE27_9FIRM Length = 278 Score = 322 bits (825), Expect = 1e-86, Method: Composition-based stats. Identities = 113/280 (40%), Positives = 157/280 (56%), Gaps = 2/280 (0%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M+A+IIDG +A +++ ++ Q V + + PGLA+V+V S A + K++ CE+ Sbjct: 1 MSARIIDGSAVAGELQQQIKQDVAKLKSENKQLPGLAIVVVSSPKARKNIAELKKRMCEK 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG + L + + +++ LI+ LN D I GI + P+P ID V++ + P KDV Sbjct: 61 VGIHCEIHKLNPLSGQDDVIALIEKLNKDPKITGINIH-PVPDHIDYRAVVQALDPAKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 +G HP N G + P TPR I+ LLE D G AV++G S VG P+ LL Sbjct: 120 EGVHPMNQGNFLIGDKKFIPFTPRAIMRLLESTGEDLKGKRAVIVGRSQHVGLPVGFLLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T T H + L AD+LIVA G P I G IK GAIVIDVG N + G++ Sbjct: 180 EKHATVTYAHSRSWYLEDVTRLADILIVAAGHPEMITGSMIKPGAIVIDVGTN-IVGGQL 238 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 VGDV A + A +ITPVPGGVGPMTVA L+ N ++ C Sbjct: 239 VGDVEHHTAQRVAGWITPVPGGVGPMTVAMLLMNLVECCE 278 >UniRef50_D1CB15 Methylenetetrahydrofolate dehydrogenase (NADP(+)) n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CB15_THET1 Length = 285 Score = 320 bits (822), Expect = 2e-86, Method: Composition-based stats. Identities = 104/277 (37%), Positives = 168/277 (60%), Gaps = 1/277 (0%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 I+DGK +A+ +R ++ ++QA + P LAVVL P + +Y + +K +++G Sbjct: 7 NILDGKAVAKTIRQQLESQIQAFQTSRGYVPNLAVVLPSEEPDACLYAQNLQKWFQKLGL 66 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + L + ++ +L I +L + + G+++Q+PLP G+ + V E + P KDV+G Sbjct: 67 GCFVHQLSSSITQEDLCAYIRSLCSSADVHGVMIQMPLPDGVSYLSVAEALDPMKDVEGI 126 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 HPYN G L P++ P TP TL++ Y ID G N VVIG SN+VG+P + +L+ Sbjct: 127 HPYNFGLLSIGNPQVVPSTPMAAATLIDHYGIDVSGKNVVVIGRSNVVGKPFAQLMLMKH 186 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 + +V H +K++R + NAD++ VAVG+P + D ++EG IVID GIN + + ++VGD Sbjct: 187 ASVSVLHSRSKSIRDYTLNADIVAVAVGRPNTLTADMVREGVIVIDFGINFVND-RLVGD 245 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 V FE + AS+ITPVPGG+GP+T L N ++ + Sbjct: 246 VDFEAVSPLASFITPVPGGIGPLTNLMLASNLIKLAL 282 >UniRef50_C7N2I9 Methenyltetrahydrofolate cyclohydrolase /5,10-methylenetetrahydrofolate dehydrogenase (NADP+) n=7 Tax=Bacteria RepID=C7N2I9_SLAHD Length = 284 Score = 320 bits (821), Expect = 3e-86, Method: Composition-based stats. Identities = 101/282 (35%), Positives = 151/282 (53%), Gaps = 3/282 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A+I+ GK +A + ++A +++A AAG+ P LA++ VG Y K E + Sbjct: 1 MAEILYGKPVADAINEKLAPRIEALKAAGV-TPQLAILRVGERDDDLSYERGAIKRFEAL 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G R + LPE S++ELL ++D +N D +I G L+ PLP +D E + P+KD D Sbjct: 60 GLDCRRFVLPENCSQSELLNVVDWINKDESIHGCLMFRPLPKHLDEAAACEALAPEKDAD 119 Query: 122 GFHPYNV-GRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 G ++ G R PCT + +L Y + G V+G S ++G+P+SM L Sbjct: 120 GITEGSLFGVFANRPVGFPPCTADACMKVLSHYGYELTGAKLAVVGRSLVIGKPVSMMLQ 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE-NGK 239 A T T+ H TK+L AD+L+VA G G + ++EG +VIDVGIN + GK Sbjct: 180 AANATVTMCHTRTKDLSAACREADILVVAAGHIGTVGASEVREGQVVIDVGINWDDAAGK 239 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 + GDV F++ + ITPVP GVG +T A L E+ + A Sbjct: 240 LCGDVTFDEVEPVVAAITPVPRGVGSVTTAVLAEHVVTAAER 281 >UniRef50_UPI00017F08E4 PREDICTED: similar to MGC137793 protein n=1 Tax=Sus scrofa RepID=UPI00017F08E4 Length = 933 Score = 319 bits (817), Expect = 1e-85, Method: Composition-based stats. Identities = 104/254 (40%), Positives = 152/254 (59%), Gaps = 10/254 (3%) Query: 41 VGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLP 100 VG+ S +Y+ K KA +E+G + LP T +E+E+L+ I +LN D T+ G ++QLP Sbjct: 59 VGNRDDSNLYINVKLKAAKEIGIKAMHIKLPRTATESEVLKCITSLNEDLTVHGFILQLP 118 Query: 101 LPAG--IDNVKVLERIHPDKDVDGFHPYNVGRLCQR--APRLRPCTPRGIVTLLERYNID 156 L + I+ ++ I P+KDVDG N G+L + PCTP+G + L+++ + Sbjct: 119 LDSENPINAEALINAIAPEKDVDGLTSINAGKLARGDLNDCFIPCTPKGCLELIKQTGVQ 178 Query: 157 TFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFI 216 G AVVIG S IVG PM LL T T H T NL V D+++VA GKP + Sbjct: 179 IAGRQAVVIGRSKIVGAPMHDLLLWNHATVTTCHSKTANLNEEVNKGDIVVVAAGKPEMV 238 Query: 217 PGDWIKEGAIVIDVGINRLEN------GKVVGDVVFEDAAKRASYITPVPGGVGPMTVAT 270 G+WIK GA+VID GIN + ++VGDV + +A +RA +ITPVPGGVGPMTVA Sbjct: 239 KGEWIKPGAVVIDCGINCKPDDTKPSGKRIVGDVAYSEAKERAGFITPVPGGVGPMTVAM 298 Query: 271 LIENTLQACVEYHD 284 L+++T+++ + + Sbjct: 299 LMQSTVESAEHFLE 312 >UniRef50_C9LM47 Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase n=1 Tax=Dialister invisus DSM 15470 RepID=C9LM47_9FIRM Length = 281 Score = 318 bits (816), Expect = 1e-85, Method: Composition-based stats. Identities = 114/274 (41%), Positives = 162/274 (59%), Gaps = 2/274 (0%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+DGK A + ++ +++ G LAV+L GS+ S +Y +KA G Sbjct: 2 ILDGKVTAAALEKDIRERIDVLKERGCTL-KLAVILAGSSKPSHMYAEFMKKAALSYGIG 60 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + Y+ PE E EL LI LN + +I GIL+ +PLP I K++E IHPDKD+DG Sbjct: 61 TELYEKPENVKEDELGALIQALNGNPSITGILMMMPLPGHIHEEKMIEMIHPDKDMDGLT 120 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 N GRL L TPR ++ +L+ Y I G +AV+IG SN++G+P++M L+ Sbjct: 121 TVNAGRLFSGKDGLFGGTPRAVMAILKHYGISVEGKHAVIIGRSNVIGKPVAMMLMQKNA 180 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+ H TKNL + AD+L+ AVGK G + D +K GAIV+DVGINR+ GK VGDV Sbjct: 181 TVTICHSRTKNLSEITQQADILVTAVGKAGCVTADMVKPGAIVLDVGINRIH-GKTVGDV 239 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 +E+ A +TPVPGGVG +T +IE+ ++A Sbjct: 240 DYENVFPVAGAVTPVPGGVGSVTTTMIIESIVKA 273 >UniRef50_Q7TU81 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Prochlorococcus marinus subsp. pastoris str. CCMP1986 RepID=FOLD_PROMP Length = 298 Score = 318 bits (815), Expect = 2e-85, Method: Composition-based stats. Identities = 117/276 (42%), Positives = 170/276 (61%), Gaps = 5/276 (1%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 +DGK ++ ++ + + R PGLAV+ +G +PAS +YV +K KAC VG S Sbjct: 5 LDGKKLSLEIEERLRNYILTNKTIAKRNPGLAVIRIGEDPASGVYVGNKEKACSRVGIKS 64 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 + L +T + E+ +L++ LN DN IDG+L+QLP+ D +++ I+P+KDVDG + Sbjct: 65 YIFHLKDTVEQKEVEQLLNKLNLDNNIDGMLLQLPISKKFDEQRLISFINPEKDVDGLNE 124 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCT 185 N+G+L + +R CTP GIV LL+ NI G VVIG S +VG+P+S+ +L T Sbjct: 125 QNIGKLVKNEQAMRSCTPAGIVNLLKSQNIKIEGKKIVVIGRSLLVGKPLSLMMLNLNAT 184 Query: 186 TTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-----KV 240 T+TH T NL + AD+LI A GKP I ++KEGA++IDVGI+RL + ++ Sbjct: 185 VTITHSKTINLNKICKEADILIAAAGKPNLINSSFVKEGAVIIDVGIHRLTSSDKSKTRL 244 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 GDV+ ED + TPVPGGVGPMTV L+ NT+ Sbjct: 245 CGDVLLEDVIPKVFAYTPVPGGVGPMTVTMLLVNTI 280 >UniRef50_C4FZX7 Putative uncharacterized protein n=1 Tax=Abiotrophia defectiva ATCC 49176 RepID=C4FZX7_ABIDE Length = 283 Score = 318 bits (815), Expect = 2e-85, Method: Composition-based stats. Identities = 94/278 (33%), Positives = 149/278 (53%), Gaps = 1/278 (0%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 KII GK +A+ + +E+ K ++ R P L ++ VG P Y K + +G Sbjct: 2 KIISGKEVAEHITAELKNKAESLKKGNRRLPKLVIIRVGEKPDDLSYQKGAVKRMDMIGV 61 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + E + E + D +N D ++DGILV P+P +D +++ I+P KD+D Sbjct: 62 IHEEVHFEENVPKEEFYKEFDEINNDESVDGILVLRPIPKHLDEDRLMNTINPKKDIDAI 121 Query: 124 HPYNVGRLCQR-APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 P ++G+L PCT G++ +L+ + G +IG SN+VGRP+++ + Sbjct: 122 SPVSLGKLMTGDKNGFAPCTAAGVIEILKYAGVKIRGKKVTIIGRSNVVGRPLALLFVSE 181 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T TV H FT +++ +NA++L+ + GK I +++ E A+VIDVGIN ENGK+ G Sbjct: 182 DATVTVCHSFTADVKQAGKNAEILVASCGKAKLINSEYVAENAVVIDVGINFDENGKLCG 241 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 DV D A+ TPVPGGVG +T + L + L A Sbjct: 242 DVDINDIEAVAAACTPVPGGVGAVTTSMLAKQLLLAYE 279 >UniRef50_C6LCK2 Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase n=7 Tax=Bacteria RepID=C6LCK2_9FIRM Length = 282 Score = 314 bits (804), Expect = 3e-84, Method: Composition-based stats. Identities = 98/282 (34%), Positives = 151/282 (53%), Gaps = 3/282 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 MA +++ GK + + + V A G+ P LA++ VG NP+ Y K CE Sbjct: 1 MAKQLL-GKEVTAALNERIKANVAACQEKGVN-PTLAIIRVGENPSDISYEKGATKRCET 58 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G LPE ++ ELL +ID +N D+ I G+L+ PLP +D + + +KDV Sbjct: 59 LGVACEKILLPEDVAQEELLAVIDKVNKDDKIHGVLLFRPLPKHLDQAVIENALAAEKDV 118 Query: 121 DGFHPYNV-GRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 D ++ G + PCTP+ + +L+ Y ID G AVVIG S +VG+P +M L Sbjct: 119 DCMTDLSMSGVFTGKKIGFPPCTPQACMEILDHYGIDCTGKKAVVIGRSLVVGKPAAMML 178 Query: 180 LLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGK 239 + T T+ H T ++ AD++IVA G+ G + +++KEG +IDVGIN GK Sbjct: 179 VKKNATVTICHTRTVDMPSVAREADIIIVAAGRAGVVGAEYVKEGQTIIDVGINVNAEGK 238 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 + GDV + ITPVPGGVG +T + L+ + ++A + Sbjct: 239 LCGDVDYAAVEPIVDAITPVPGGVGSVTTSVLVGHVVEAAMR 280 >UniRef50_A8SN78 Putative uncharacterized protein n=1 Tax=Parvimonas micra ATCC 33270 RepID=A8SN78_9FIRM Length = 283 Score = 313 bits (802), Expect = 5e-84, Method: Composition-based stats. Identities = 106/279 (37%), Positives = 161/279 (57%), Gaps = 2/279 (0%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+ GK +A ++ ++ V G + VG S Y + K +G Sbjct: 4 IMKGKEVAIALKEKIKAGVAELKEKGKVTTC-GFIRVGDRSDSIGYENAAIKVLSSLGIE 62 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + PE +EA+ + ++ + D+++DG L+ PLPA ID+ V +I+P KD+DG Sbjct: 63 CVQFHYPEDITEADFISELEKIGNDDSVDGFLLLRPLPAHIDDDLVGMKINPKKDIDGVS 122 Query: 125 PYNVGR-LCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 PYN+G + PCT ++ +LE Y++D G NAVV+G SN++G+P++M LL Sbjct: 123 PYNIGEVFYPKEDSFIPCTAAAVIKMLEFYDLDLTGKNAVVLGRSNVIGKPVAMLLLAKN 182 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T TV H T+NL+ +NAD+L+ A+GK F+ + +KEGAIV+DVG N ENGKV GD Sbjct: 183 ATVTVCHSRTQNLKEVCKNADVLVSAIGKAHFVTKELVKEGAIVVDVGTNYDENGKVTGD 242 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 V F++ ++ ASYI PVPGG+G +T + L E L A + Sbjct: 243 VDFDEVSEIASYINPVPGGIGSITTSVLAEKCLIAARKK 281 >UniRef50_Q057D7 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=Gammaproteobacteria RepID=FOLD_BUCCC Length = 284 Score = 311 bits (798), Expect = 1e-83, Method: Composition-based stats. Identities = 151/283 (53%), Positives = 209/283 (73%), Gaps = 3/283 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M KI+DG I++++ ++ +K++ R + PGLA++++G+NPAS IYV KR+AC + Sbjct: 1 METKILDGLKISKKIIKKIKKKIEKRKKKRKKIPGLAMIVIGNNPASLIYVNKKREACNQ 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 GF S + L E EL+ LI LN + IDGIL+QLPLP I+ +K++ I P KDV Sbjct: 61 AGFFSIYWHLSNQIEEIELINLIKKLNKNKCIDGILIQLPLPIKINYLKIITSIDPKKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHPYN+G LCQ P+ R CT +G++TLL++Y I+ GL AV+IG+SNIVG+PM MELL Sbjct: 121 DGFHPYNLGSLCQNNPQFRSCTSKGVITLLKKYKINIHGLYAVIIGSSNIVGKPMYMELL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-- 238 LAGCT T+ ++ TKN++ +V+ ADL+++A+G+P F+ G WIK GAIVID+GIN L N Sbjct: 181 LAGCTVTIVNKNTKNIKTYVKKADLVVIAIGQPNFLYGHWIKLGAIVIDIGINYLYNKNK 240 Query: 239 -KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 K+VGDV F+ + + SYITPVPGGVGPMTV +L+ENTLQAC+ Sbjct: 241 YKIVGDVHFKSTSVKTSYITPVPGGVGPMTVVSLLENTLQACI 283 >UniRef50_C0R292 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=Brachyspira RepID=FOLD_BRAHW Length = 281 Score = 310 bits (796), Expect = 2e-83, Method: Composition-based stats. Identities = 112/275 (40%), Positives = 172/275 (62%), Gaps = 4/275 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 + I+DG+ +A++++ + ++ + + P + + + ++++Y +K E V Sbjct: 1 MSNILDGRELAKEIKERIKKETEILE----KKPRIDFLYFEDDKSTEVYFTRAKKQAESV 56 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + ++LP T+E + L LI+ LN ++ GI++Q+PLP I KV E I +KD D Sbjct: 57 GMIGSLHNLPVNTTEKDFLTLIEYLNEESETSGIMIQMPLPKHISKKKVYETISIEKDAD 116 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 N+GR+ L PCT + + L+E+ I+ G NAVVIG S IVG+P++ LL Sbjct: 117 AISHVNLGRIFIGDSNLAPCTAKSAMALIEKSGINIEGANAVVIGRSEIVGKPLAHLLLQ 176 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 T T+ H TKNL+ +NAD+L V++GK FI G++IKEGA+VIDVGIN LE+G + Sbjct: 177 KSATVTIAHSKTKNLKELCKNADILCVSIGKAEFITGEYIKEGAVVIDVGINVLEDGSLK 236 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 GDV FE+A+K ASYITPVP GVG +TV+ L++N L Sbjct: 237 GDVNFEEASKLASYITPVPNGVGSVTVSMLLDNVL 271 >UniRef50_A9NE96 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Acholeplasma laidlawii PG-8A RepID=FOLD_ACHLI Length = 277 Score = 310 bits (796), Expect = 3e-83, Method: Composition-based stats. Identities = 115/281 (40%), Positives = 159/281 (56%), Gaps = 5/281 (1%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 ++DG+ A + + KVQ + P L ++L+G++ AS+ YV K +G Sbjct: 2 LLDGRKTADILNEALRVKVQYLT----KKPKLEIILIGNDEASKSYVKGKLNTASNLGME 57 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 L E + + LI LN D + GIL+QLP+P +D+ ++ I KDVDGFH Sbjct: 58 VHINYLDEAIDQLSVEALIQKLNTDKGVHGILLQLPIPKHLDSDYLISLIDYKKDVDGFH 117 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 N G L Q+ +RP TP GI+ LL+ YNI G + V+IG S IVG P+S L Sbjct: 118 TMNQGLLFQKKDGIRPATPLGIMMLLDFYNIPIEGKHVVIIGRSQIVGAPLSKMFLDRNA 177 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+TH TKNL + AD+L+ A+GKP F+ D +K GA+V+DVGINR+ + K+VGDV Sbjct: 178 TVTITHSKTKNLPSITKQADILVAAIGKPKFVTKDMVKVGAVVVDVGINRV-DKKLVGDV 236 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDP 285 FE ASYITPVP GVGPMT+ L N ++ Sbjct: 237 DFEHVEPIASYITPVPKGVGPMTICALAHNLYALYLKQEKE 277 >UniRef50_D2RNA3 Methylenetetrahydrofolate dehydrogenase (NADP(+)) n=2 Tax=Acidaminococcus RepID=D2RNA3_ACIFE Length = 272 Score = 310 bits (796), Expect = 3e-83, Method: Composition-based stats. Identities = 104/277 (37%), Positives = 155/277 (55%), Gaps = 7/277 (2%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M I+ GK +A+++R + +K + LA LVG NPA+ +Y S K Sbjct: 1 MEPIIMAGKPVAEEIRRNLREKFA------GKELTLATFLVGDNPAAHVYKRSLLKTAAS 54 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G +R +LPE S+ E + L+ D +DGIL +P P I ++++ ++ P+KD+ Sbjct: 55 LGIHTRDVELPEGASQEEAERALRALSEDPRVDGILPLVPFPWHISRMQLIRQLDPEKDM 114 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 D HP N G+L PCTPR + LL+ Y I G + V++G +VGRP+++ L+ Sbjct: 115 DCIHPINGGKLYLGITPWGPCTPRSCMALLDYYKIPLEGQHVVMVGYGEVVGRPLTLMLM 174 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T TV TKNL AD++I AVGKP I D I+EGA+V+DVGIN + +GK+ Sbjct: 175 GRYATVTVCRSRTKNLPAITRQADIIISAVGKPDLITEDMIREGAVVVDVGINSV-DGKL 233 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 VGDV +AS TPVPGGVG ++ ++E + Sbjct: 234 VGDVSEAAKKVKASAYTPVPGGVGVVSNLMVMETLTR 270 >UniRef50_O65269 F6N23.28 protein n=1 Tax=Arabidopsis thaliana RepID=O65269_ARATH Length = 310 Score = 310 bits (796), Expect = 3e-83, Method: Composition-based stats. Identities = 114/292 (39%), Positives = 158/292 (54%), Gaps = 44/292 (15%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A +IDGK A+++R ++ +V + P Sbjct: 55 AIVIDGKAEAKKIRDDIKIEVSRMKESIGVVPA--------------------------- 87 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 E +SE E+L+ + N D ++ G+LVQLPLP+ +D +L + +KDVDG Sbjct: 88 ---------EDSSEEEVLKYVSGFNDDPSVHGVLVQLPLPSHMDEQNILNAVSIEKDVDG 138 Query: 123 FHPYNVGRLCQR--APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 FHP N+GRL R P PCTP+G + LL RYNI+ G AVVIG SNIVG P ++ L Sbjct: 139 FHPLNIGRLAMRGREPLFVPCTPKGCIELLHRYNIEFKGKRAVVIGRSNIVGMPAALLLQ 198 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-- 238 T ++ H T N AD+LI AVGKP + G WIK GA++IDVGI +E+ Sbjct: 199 KEDATVSIIHSRTMNPEELTRQADILISAVGKPNMVRGSWIKPGAVLIDVGIKPVEDPSA 258 Query: 239 ----KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 ++VGD+ + +A+K AS ITPVPG VGPMT+A L+ NTL + H+ Q Sbjct: 259 AGGERLVGDICYVEASKIASAITPVPGDVGPMTIAMLLSNTLTSAKRIHNFQ 310 >UniRef50_Q21285 Dauer or aging adult overexpression protein 3, confirmed by transcript evidence n=2 Tax=Caenorhabditis RepID=Q21285_CAEEL Length = 303 Score = 310 bits (796), Expect = 3e-83, Method: Composition-based stats. Identities = 119/299 (39%), Positives = 163/299 (54%), Gaps = 11/299 (3%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAG-LRAPGLAVVLVGSNPASQIYVASKRKACE 59 M A+I+ G +++V +V QK+ LA+V VG+ S +Y+ SK K + Sbjct: 1 MVAEIVSGLEYSKKVLHDVGQKIAKTREHHPNFHAVLAIVQVGNRSDSNVYINSKLKKAK 60 Query: 60 EVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAG--IDNVKVLERIHPD 117 E+G + LP+T ++ +L I LN DN IDGI++QLPL ID V++ I P Sbjct: 61 EIGADGKLIKLPDTITQGDLKREIMALNHDNEIDGIIIQLPLDCKHEIDADSVIDLIDPL 120 Query: 118 KDVDGFHPYNVGRLCQR--APRLRPCTPRGIVTLLERYNID---TFGLNAVVIGASNIVG 172 KDVDG N GRL + + PCTP G + L+++ D G VV+G S IVG Sbjct: 121 KDVDGLTRINAGRLARGELQRTIFPCTPFGCLYLVQQATGDANFVSGKEVVVLGRSKIVG 180 Query: 173 RPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGI 232 P + L T T+ H T NL+ AD+LIVA+G+ F+ DWIK GA VID GI Sbjct: 181 SPAAALFLWHHGTVTICHSKTPNLKEKCLRADILIVAIGRKHFVKADWIKPGAFVIDCGI 240 Query: 233 NRLEN---GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQDE 288 N ++ K+ GDV E A + A ++TPVPGGVGPMTVA LI NT + Q + Sbjct: 241 NVGDDPNSRKIYGDVDTEAAKEVAGFLTPVPGGVGPMTVAMLIRNTFEQAKRRRLGQKD 299 >UniRef50_C4Z3I2 Methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase n=3 Tax=Clostridiales RepID=C4Z3I2_EUBE2 Length = 280 Score = 309 bits (793), Expect = 6e-83, Method: Composition-based stats. Identities = 96/276 (34%), Positives = 146/276 (52%), Gaps = 4/276 (1%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 + G +A + ++ ++++ P LA+V VG P Y K E+VGF Sbjct: 4 LKGLPVANAINEKIIEEMKDWK---GAIPHLAIVRVGERPDDMSYERGATKKMEKVGFRC 60 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 SY P + D +N D IDGIL+ PLP +D + RI KD+DG P Sbjct: 61 TSYTFPADIDNDTFQKEFDKINEDEDIDGILLLRPLPKHLDEKAIENRIASVKDLDGISP 120 Query: 126 YNVGRLCQRAP-RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 N+ ++ P PCT ++ +L+ +D G AVVIG S ++G+P++M L+ Sbjct: 121 MNLAKVYAGDPTGYGPCTAEAVIEMLDYAGVDLKGKRAVVIGRSLVIGKPVAMMLMKKNA 180 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T TV H T ++ + A++L+ A G + ++ +GA+VIDVGIN E+G + GDV Sbjct: 181 TVTVCHTKTVDMPGVCKGAEVLVAAAGVAKMVDKSFVADGAVVIDVGINVDEDGNLCGDV 240 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 FED A+ AS TPVPGGVG +T + L ++ L+A Sbjct: 241 DFEDVAENASVCTPVPGGVGSVTTSVLAKHLLKAAK 276 >UniRef50_D1C3C2 Methylenetetrahydrofolate dehydrogenase (NADP(+)) n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C3C2_SPHTD Length = 286 Score = 309 bits (791), Expect = 1e-82, Method: Composition-based stats. Identities = 102/278 (36%), Positives = 157/278 (56%), Gaps = 2/278 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A ++G+ +A+ + +++ + P LA VL G + ++ YV + + + V Sbjct: 1 MAIALEGRPVARAILERAREELAEYVTQAGHPPELATVLAGDDASAAAYVRAIHRTFDRV 60 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G R LP +E+EL + ++ LNAD + GI++ PLP + + + P KDVD Sbjct: 61 GIPVRDVTLPGDVAESELRDAVERLNADPAVSGIIILHPLPRHLPAGIASQLVDPAKDVD 120 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G PY+ GRL P L P TP G + +LE Y I+ G +AVVIG S +VG PM++ L+ Sbjct: 121 GVTPYSAGRLAVGLPALPPSTPEGGMAILEHYGIEIAGSHAVVIGRSPVVGLPMALMLIA 180 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 A T TV H T +L AD+L+ A G+PG + + +K GA VID G++ + +G++V Sbjct: 181 ADATVTVCHSRTPDLPAMTRQADILVAAAGRPGLVRPEMVKPGATVIDFGVSFV-DGRMV 239 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 GDV + A +TPVPGG G +T A L++NTL+A Sbjct: 240 GDVE-PAVGEVAGALTPVPGGTGAVTNAILVQNTLRAA 276 >UniRef50_Q83FS2 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Tropheryma whipplei RepID=FOLD_TROWT Length = 295 Score = 308 bits (790), Expect = 1e-82, Method: Composition-based stats. Identities = 117/288 (40%), Positives = 157/288 (54%), Gaps = 9/288 (3%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M AK++DG ++ + + + P LA VLVG+NPAS+ YV SK + C+ Sbjct: 1 MVAKVLDGLAVSAGIFERLHRACCEL-ENNGVCPKLATVLVGNNPASRSYVLSKHRDCKN 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G S +LP TSE EL+ ++ LNA + + GI+VQLPLP ID KV+E I+PDKD Sbjct: 60 IGIQSTLIELPANTSEKELISKVEILNASSDVSGIIVQLPLPESIDQNKVIEAINPDKDA 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG HP N+G L + PCTP GIV LLE + I G VIG VGRP+ + L Sbjct: 120 DGLHPLNLGYLVTGKQGIVPCTPAGIVKLLEAHRITLEGKTIAVIGRGTTVGRPLGILLS 179 Query: 181 LAG--CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGIN---RL 235 G T H ++N+ AD+++ G + WIK GA+V+DVGIN Sbjct: 180 GKGVNATVINIHSRSRNISGLSRIADVVVACAGVKHIVEPSWIKPGAVVVDVGINQSGVS 239 Query: 236 ENGK--VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 +GK + GDV ASYI+PV GGVGPMT A L+ N + Sbjct: 240 SSGKMILTGDV-HPLTKNIASYISPVVGGVGPMTRAMLMSNVINLSER 286 >UniRef50_Q0S375 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=Actinobacteridae RepID=FOLD2_RHOSR Length = 286 Score = 308 bits (790), Expect = 1e-82, Method: Composition-based stats. Identities = 118/283 (41%), Positives = 159/283 (56%), Gaps = 5/283 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A I+DGK ++ ++ +V A G+ PGL VLVG +P S YV K C + Sbjct: 1 MTATILDGKATRDEIFEDLKVRVSALKDRGI-TPGLGTVLVGDDPGSAAYVRGKHNDCAK 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG S DLP ++ +L ID LNA+ G +VQLPLP +D LERI PDKD Sbjct: 60 VGITSIRRDLPGDITQEKLDATIDELNANPDCTGYIVQLPLPKQLDENAALERIDPDKDA 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG HP N+GRL PCTPRGI+ LL RY + G + VV+G VGRP+ + Sbjct: 120 DGLHPVNLGRLVLGKKAPLPCTPRGILHLLRRYEVPIEGAHVVVVGRGVTVGRPIGLLFT 179 Query: 181 LA--GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 T T+ H T++L V AD++I A G PG I D +K GA V+DVG++R +G Sbjct: 180 RRSENATVTLCHTRTRDLGAEVRRADIVIAAAGVPGLITADMVKPGAAVLDVGVSRTADG 239 Query: 239 KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 + GDV D A+ A +++P PGGVGP+T A L+ N ++ Sbjct: 240 -LRGDVA-ADVAEVAGFLSPNPGGVGPLTRAFLLTNVVERAER 280 >UniRef50_B0VGJ7 FolD bifunctional protein n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VGJ7_9BACT Length = 307 Score = 307 bits (786), Expect = 4e-82, Method: Composition-based stats. Identities = 101/290 (34%), Positives = 162/290 (55%), Gaps = 12/290 (4%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 K+++GK +AQ + + + IA P + ++ VG +PAS YV S + +++G Sbjct: 7 KVLNGKPVAQLIN----RTCSSLIANYGLKPQMVLIQVGDDPASTYYVQSIINSGKKLGC 62 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + L + SE ELL +++ N + ++GI++Q PLP I+ KV I+P KD+D Sbjct: 63 FCQMKILLDNISEQELLAILNEANHNPDVNGIMLQKPLPKHINESKVNSAINPAKDLDCL 122 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA- 182 HP N+G++ PCTP ++ + Y I+T G + V++G SN+VG+P++ LL Sbjct: 123 HPLNLGKIMLEEEGFLPCTPAAVLFCMLYYGIETQGKHIVILGRSNVVGKPLANILLWKR 182 Query: 183 ---GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE--- 236 T TV H T NL + AD+LI A+GK F+ + +KE AI++DVGIN ++ Sbjct: 183 SFANATVTVCHSKTNNLAEFTKEADILITAIGKAEFVTPEMVKENAIILDVGINEIKLAN 242 Query: 237 -NGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDP 285 VGDV + +A ITPVPGG+G +T + L N + AC++ + Sbjct: 243 GESNYVGDVNYSLCYDKALAITPVPGGIGRITTSVLFLNLVDACLKSRNT 292 >UniRef50_A8RJW5 Putative uncharacterized protein n=2 Tax=Clostridium bolteae ATCC BAA-613 RepID=A8RJW5_9CLOT Length = 281 Score = 306 bits (784), Expect = 7e-82, Method: Composition-based stats. Identities = 97/281 (34%), Positives = 144/281 (51%), Gaps = 4/281 (1%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 KI+ G ++ +++ +V Q ++ AP LA+V VG P Y K E G Sbjct: 2 KILKGAEVSAKIKEQVTQMMEGLE---GPAPKLAIVRVGEKPDDMSYERGAVKKMENFGL 58 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 ++Y PE S+++ +N D + GIL+ PLP I + + I P+KD+DG Sbjct: 59 RVQTYVFPEQISDSDFKAEFSAINRDPDVSGILLLRPLPKQIAETDIEKMIDPEKDLDGI 118 Query: 124 HPYNVGR-LCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 P N+ + PCT ++ +L+ ID G N ++G S +VGRP+SM +L Sbjct: 119 SPANIAKVFAGDKTGFAPCTAEAVIEVLKANEIDMTGKNVTIVGRSMVVGRPLSMLMLKE 178 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T T+ H T++L A++L+ A GK + G + + AIVIDVGIN ENGK+ G Sbjct: 179 NATVTICHTRTRDLETECRRAEILVAAAGKAKMLDGRHVGQDAIVIDVGINVDENGKLCG 238 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 DV F AS TPVPGGVG +T A L ++ + A Sbjct: 239 DVDFPSIEPLASMATPVPGGVGAVTTAVLAKHLVLAGRRQR 279 >UniRef50_C7MLE6 Methenyltetrahydrofolate cyclohydrolase /5,10-methylenetetrahydrofolate dehydrogenase (NADP+) n=4 Tax=Coriobacteriaceae RepID=C7MLE6_CRYCD Length = 293 Score = 305 bits (783), Expect = 8e-82, Method: Composition-based stats. Identities = 95/283 (33%), Positives = 147/283 (51%), Gaps = 3/283 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A+I + + + E + V A G+ P LA++ VG+ P Y RK CE Sbjct: 1 MAQIWKAAPVVEALAEETDRLVAQVTAQGI-TPQLAIIRVGNRPDDISYERGARKRCEAR 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + +++L +++ EL+ I +N D I G L+ PLPA ++ + P KD+D Sbjct: 60 GIAATTFELAAESTQDELMTTIQHINDDPAIHGCLMLRPLPASLNEEAATAVLLPQKDID 119 Query: 122 GFHPYNV-GRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 G P ++ G Q PCT + ++ +L+ Y G N VIG S +VGRP+S+ L Sbjct: 120 GITPSSLFGVFAQETVGFAPCTAQAVIEVLDHYGAHLDGTNVCVIGRSLVVGRPVSLMLQ 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE-NGK 239 T T+ H T+ ++ AD+++ A+G+ I DW+ G +VIDVGIN K Sbjct: 180 KRNATVTMCHSHTRTIQQVCRQADIVVAAIGQAHTIDVDWVSPGQVVIDVGINWDSAASK 239 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 +VGDV F+ + + ITPVPGG+G +T A L ++ QA V Sbjct: 240 LVGDVDFDSVEPKVAAITPVPGGLGAVTSAVLCKHLAQAAVNQ 282 >UniRef50_C1FDF4 5,10-methylene-tetrahydrofolate dehydrogenase/cyclohydrolase n=1 Tax=Micromonas sp. RCC299 RepID=C1FDF4_9CHLO Length = 396 Score = 305 bits (782), Expect = 1e-81, Method: Composition-based stats. Identities = 122/338 (36%), Positives = 172/338 (50%), Gaps = 57/338 (16%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQ-ARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 +A ++DG+ A + + E+A K+ R + + PGLA V++G P S +YV K +ACEE Sbjct: 56 SAIMLDGRLQAARWKREIAAKILFRRTSKRMGPPGLAAVVIGDRPDSLLYVRRKSEACEE 115 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG LP + ++ ++ LN+D+ GI++QLP+P ++ ++L I+P KDV Sbjct: 116 VGIRFHLERLPGDADQDMVVNVLRKLNSDDRFHGIMLQLPVPVHLNESRLLGSINPMKDV 175 Query: 121 DGFHPYNVGRLCQR---APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSM 177 DG HPYNVGRL R P PC P G V LL R NI G + V+G SN+VG P+S Sbjct: 176 DGLHPYNVGRLAMRGTWRPAFIPCAPLGCVELLWRENIQIKGRSVAVLGDSNVVGMPISW 235 Query: 178 ELLLAGC-TTTVTHRF-------------------TKNLRHHVENADLLIVAVGKPGFIP 217 L +G T V H + NL + V NAD++I A+G+ I Sbjct: 236 LLRDSGASTINVVHGYWLKVPEQNNMKFPAQANFVEPNLLNTVRNADIIISAIGRAEVIK 295 Query: 218 GDWIKEGAIVIDVGINRLE---------------------------------NGKVVGDV 244 DW+K GA VIDVGIN + + KVVGDV Sbjct: 296 RDWVKAGATVIDVGINPIPWDHHEGIARCRHASSRKVPAAFLEQRPDKPEKSDYKVVGDV 355 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 E+ + A+ +TPVPGG+GPMT+A L+ NT Sbjct: 356 AAEEVSHVANAMTPVPGGIGPMTIAALLSNTYLGASRQ 393 >UniRef50_A5CF58 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Orientia tsutsugamushi RepID=FOLD_ORITB Length = 301 Score = 305 bits (781), Expect = 1e-81, Method: Composition-based stats. Identities = 119/282 (42%), Positives = 155/282 (54%), Gaps = 6/282 (2%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+DGK +A+ E + A L ++LVG+N AS IYV +K + +G Sbjct: 4 IMDGKKLAELRLIETKNDLLALKDKYQITVKLVIILVGNNDASLIYVNNKVAKAKAIGMD 63 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S L E E +L +ID LN D+T+ GI+VQLPLP ID +K+ RI KDVDG + Sbjct: 64 SEIIRLFEFIEEKKLFSVIDDLNCDSTVHGIIVQLPLPPHIDALKLFARIDSRKDVDGLN 123 Query: 125 PYNVGRLCQRAP-RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 P N+G L A L PCT G + LL+ Y G + VVIG SNIVG+P+S LL Sbjct: 124 PINIGYLNIGANQGLIPCTALGCIDLLQYYVTGLKGKHVVVIGKSNIVGKPLSALLLRNS 183 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN-----G 238 CT T+ H T +L H AD++I AVGK F+ IDVGI+ + + Sbjct: 184 CTVTICHSATVDLALHTRTADIVISAVGKANFLTDKHFSGNLAFIDVGISHIYDLQTHKR 243 Query: 239 KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 K+VGD F +ITPVPGGVGPMTVA L++NTL A Sbjct: 244 KLVGDGDFLKIKDLVKFITPVPGGVGPMTVAYLLKNTLTAAK 285 >UniRef50_B7AQ13 Putative uncharacterized protein n=3 Tax=Bacteria RepID=B7AQ13_9BACE Length = 286 Score = 304 bits (780), Expect = 2e-81, Method: Composition-based stats. Identities = 95/284 (33%), Positives = 142/284 (50%), Gaps = 6/284 (2%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A + G ++ ++ +V ++ P LA++ VG P Y K Sbjct: 7 MEA--LKGAAVSAAIKEQVQNRLAEL---DGYIPTLAIIRVGEKPDDISYEKGAMKKMAS 61 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 G +SY PE S+A E +NAD IDGIL+ PLP I + + I P KD+ Sbjct: 62 FGLNVQSYTFPEDISDALFKEEFAKINADKAIDGILMLRPLPKHICEKDIEKMIDPAKDL 121 Query: 121 DGFHPYNVGR-LCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 DG P N+ + + PCT ++ +L+ YNI G V+G S +VG+P+SM Sbjct: 122 DGISPENIAKVFAGDSTGFAPCTAEAVIEVLKAYNIPMQGKRVTVVGRSMVVGKPLSMLF 181 Query: 180 LLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGK 239 + T T+ H T +L+ A++L+ A G+ + + + A+VIDVGIN ENG+ Sbjct: 182 VKENATVTICHTRTADLKAECSRAEILVAAAGRARMLDSAYAGKDAVVIDVGINVDENGR 241 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 + GDV +E AS TPVPGGVG +T A L ++ +QA Sbjct: 242 LCGDVDYESLEGIASMATPVPGGVGAVTTAVLAKHLVQAAARAR 285 >UniRef50_D1BP88 Tetrahydrofolate dehydrogenase/cyclohydrolase n=4 Tax=Veillonellaceae RepID=D1BP88_VEIPT Length = 275 Score = 304 bits (779), Expect = 2e-81, Method: Composition-based stats. Identities = 96/274 (35%), Positives = 151/274 (55%), Gaps = 4/274 (1%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 + GK +A ++ + +KV A G +AV+LVG + + +Y K + G+ Sbjct: 4 LRGKAVADAHKAILQEKVAA---VGNSVITMAVLLVGEDHGAHMYATFMEKTAKNFGYGF 60 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 LP+T ++ E++ + LN D +I GIL +P+P ID +++ + P KD+DG Sbjct: 61 VLKQLPKTATQDEVVAALHELNTDASIHGILPLMPMPKHIDTEALIDMLDPKKDIDGLTT 120 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCT 185 YN+G + PCT + + +L YNI + VV+G S ++G+P+++ L A T Sbjct: 121 YNIGLVTAGKGGFAPCTAKACMAILNHYNISVEEKHVVVVGRSQVIGKPIALMALSAHGT 180 Query: 186 TTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVV 245 T+ H T +L V+ D++I A G+ I + IK GA+VIDVGIN L +GK VGDV Sbjct: 181 VTMCHSRTPDLAEQVKRGDIVIAAAGRAHMITANMIKPGAVVIDVGINEL-DGKTVGDVD 239 Query: 246 FEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 ++ AS ITPVPGGVG +T ++E +A Sbjct: 240 YDAVKDIASAITPVPGGVGSVTTTMMLEAVYEAY 273 >UniRef50_A9UXQ1 Predicted protein n=7 Tax=cellular organisms RepID=A9UXQ1_MONBE Length = 882 Score = 303 bits (776), Expect = 5e-81, Method: Composition-based stats. Identities = 124/297 (41%), Positives = 163/297 (54%), Gaps = 47/297 (15%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 AKIIDGK IAQ VG S +Y+ K +A E+ Sbjct: 1 MAKIIDGKAIAQ--------------------------YVGGRDDSAVYIRMKVRAGNEL 34 Query: 62 G-------FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAG--IDNVKVLE 112 + SR + L +LLE I LN D + GI+VQLPL + ID V + Sbjct: 35 PAVTFAHMYRSRLFCLA----HPQLLECIRALNDDMDVHGIIVQLPLDSQEEIDEVTITN 90 Query: 113 RIHPDKDVDGFHPYNVGRLCQRA--PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNI 170 + P+KDVDGF YN G L Q+ P L CTP+G + L+E I+ G +AVVIG S+I Sbjct: 91 AVRPEKDVDGFTRYNTGALAQKGELPLLYACTPKGCMHLIESTGIELSGKHAVVIGRSDI 150 Query: 171 VGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDV 230 VGRP+S L T T+ H T NL+ V AD+++ AVG+PG + GDW+K GA+VID Sbjct: 151 VGRPVSYLLTRRNATVTLCHSRTTNLKEEVARADIVVAAVGQPGLVQGDWLKPGAVVIDC 210 Query: 231 GINRLENG------KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 GIN +E+ ++VGDV F A++ A +ITPVPGGVGPMTVA L+ NT+ A Sbjct: 211 GINSIEDSSKKSGFRLVGDVDFASASQVAGHITPVPGGVGPMTVAMLMGNTVAAARH 267 >UniRef50_C8WXG8 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WXG8_ALIAD Length = 286 Score = 302 bits (773), Expect = 1e-80, Method: Composition-based stats. Identities = 105/279 (37%), Positives = 158/279 (56%), Gaps = 3/279 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A+ +DG+ A++V+ E+ ++V+ + G+ P L +++ ++ S +V K + Sbjct: 3 MAQRLDGRRAAERVQEELKRRVEELASRGI-LPKLVMLVSEADEVSLGHVRRKARFARGA 61 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G V+ L ID LN D+ +D ILVQLPLPAG D ++L R+ PDKDVD Sbjct: 62 GLVAEIRTFRAAEGPDALRSAIDRLNEDDEVDAILVQLPLPAGWDEGEILRRVRPDKDVD 121 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G HP N+G++ PR+ PCT RG+ LL ++ I G A VIG S +VG P++ + Sbjct: 122 GLHPENLGQMAYGLPRVWPCTARGVGELLHQHEIGVHGKVACVIGRSPLVGWPIAQWFMA 181 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 G T HR T ++ AD+++ A G PG + + ++ GA+VIDVG+ +G Sbjct: 182 HGATVVQCHRQTPSVAVWTRQADIVVSAAGAPGLVGAEEVRPGAVVIDVGLTYTADGP-R 240 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 GDV +RAS++TPVPGGVGPMTVA + +N C Sbjct: 241 GDVD-PGVRERASWLTPVPGGVGPMTVAMVAQNAFDLCA 278 >UniRef50_B5YA73 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Dictyoglomus RepID=FOLD_DICT6 Length = 283 Score = 302 bits (773), Expect = 1e-80, Method: Composition-based stats. Identities = 104/283 (36%), Positives = 160/283 (56%), Gaps = 3/283 (1%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I++GK +A+++ E+ +K++ G+ P L +V VG N ++ Y S + +G Sbjct: 4 ILEGKPVAEKLEKEIKEKIEIYKTKGI-IPNLCIVKVGENEEAEAYAKSIERFFSRIGIN 62 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + E S E + + L +N + GIL+ PL ++ K + PDKDV+G Sbjct: 63 VERKNFAENVSLLEFQKALKELEKNNKVHGILILRPLSEELERQKAFRFLSPDKDVEGIT 122 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 N+G+L PCTP+ ++ LL+ Y I G + VV+G S VG+P+S+ LL Sbjct: 123 YENLGKLFVGEKCFHPCTPQAVIELLDFYKISVEGKDVVVVGRSISVGKPLSILLLNRNA 182 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+ H TKNL A++L+ AVG+P FI D +KEG +VID+G N +E GK+VGDV Sbjct: 183 TVTICHSKTKNLEELTRRAEVLVAAVGRPHFIGKDMVKEGQVVIDIGTNVVE-GKLVGDV 241 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQD 287 FE+ + YITPVPGG+G +T L N L+A VE ++ ++ Sbjct: 242 NFEEVKDKVGYITPVPGGIGIITTRVLAMNLLKA-VEKNEARN 283 >UniRef50_C8WAB5 Tetrahydrofolate dehydrogenase/cyclohydrolase n=1 Tax=Atopobium parvulum DSM 20469 RepID=C8WAB5_ATOPD Length = 289 Score = 301 bits (772), Expect = 2e-80, Method: Composition-based stats. Identities = 98/287 (34%), Positives = 152/287 (52%), Gaps = 7/287 (2%) Query: 1 MAAKIID----GKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRK 56 M+++ I G +A+ + E+A +V+ A G+ P L +V +G Y + Sbjct: 1 MSSETISQELRGAPVAKAITEELAVQVEELRAEGI-IPRLVIVRIGQKSDDLTYERAAYM 59 Query: 57 ACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHP 116 E+VGF + +LPE ++ ++ D ++AD ++ G L P PAGID + L+ + P Sbjct: 60 RAEKVGFEVETIELPEDATQKQVNTTFDQVSADASVHGCLPMRPFPAGIDEHEALQHLTP 119 Query: 117 DKDVDGFH-PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPM 175 +KDVD + LC L PCT ++ LL+ Y + G + V+G SN++GRP+ Sbjct: 120 EKDVDCATDSMLLATLCGTPGALGPCTAEAVLALLDFYQVPLEGASIAVVGRSNVIGRPV 179 Query: 176 SMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL 235 + L T TV H TK+L ++ AD+++VA G+ I D+++ G +IDVGIN Sbjct: 180 AALLSARNATVTVCHSKTKDLAATLKQADVVVVAAGRAHLIGADYVRAGQTIIDVGINWD 239 Query: 236 ENG-KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 E K+VGDV E A S TPVPGGVG +T A L + + A Sbjct: 240 EAAQKLVGDVDTEQVAPLVSAYTPVPGGVGSVTTAILARHVVAAAQR 286 >UniRef50_C6CV64 Methylenetetrahydrofolate dehydrogenase (NADP(+)) n=1 Tax=Paenibacillus sp. JDR-2 RepID=C6CV64_PAESJ Length = 284 Score = 300 bits (770), Expect = 3e-80, Method: Composition-based stats. Identities = 93/283 (32%), Positives = 147/283 (51%), Gaps = 2/283 (0%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 K++ K A QV + KV+ G++ P +A +LV +PAS Y +K+K E++G Sbjct: 3 KLLKAKEAADQVYEGIRTKVEKWKHNGIQ-PRMAAILVEGDPASAYYAGAKQKIAEKLGV 61 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + +E E+L+L++ LN D ++ GI+++LPLP + + + I P KDVDG Sbjct: 62 AFTLHAFTAEVAEEEILQLVNRLNNDPSVHGIMLELPLPRHLSASTIEKAISPLKDVDGV 121 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 P N L P TP+ + LL+ Y G N ++G VG P+ L Sbjct: 122 TPANKLATVTGDSGLYPATPQSCIRLLQHYGYTLEGKNVTLVGRGQTVGLPLFHMLQREN 181 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T TV H T ++ H+ +A++ VAVG+P + + + ++ID GIN GK+VGD Sbjct: 182 ATVTVCHSRTPDIASHLSHAEIAFVAVGRPNIVEQNMVHSDLVIIDAGINETPQGKMVGD 241 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 V + A+ ++PVPGGVG +T A L EN ++A + Sbjct: 242 VAID-VQSSAAAVSPVPGGVGTLTTAILYENLMKAIELQFGER 283 >UniRef50_Q0SFQ8 Methenyltetrahydrofolate cyclohydrolase n=11 Tax=Actinomycetales RepID=FOLD1_RHOSR Length = 297 Score = 300 bits (770), Expect = 3e-80, Method: Composition-based stats. Identities = 103/284 (36%), Positives = 153/284 (53%), Gaps = 2/284 (0%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 + G +A +R++ + A G R P LAVV + ++ YV S A + G + Sbjct: 5 LGGAELATSIRNDASVAAAALNDLGTR-PKLAVVQATDDESTAWYVRSIASAAKRTGILC 63 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 DL S ++ + L D + GI++Q PLP G D + E I+P KDVDG +P Sbjct: 64 DIVDLGAAASTEQIRSTLVELGHDPDVHGIILQTPLPDGTDLDALREAINPAKDVDGANP 123 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCT 185 ++GRL R P P T + ++ LL+ + I A V+G S +VG P++ L+ T Sbjct: 124 VSLGRLVARLPAFAPATAQAVIALLDHHGISPHARTATVVGRSTVVGSPVAHLLVQRNAT 183 Query: 186 TTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVV 245 TV HR T +L +AD+L+VAVG PG I D + +GA+VIDVG +G+++GDV Sbjct: 184 VTVCHRHTTDLAAGTRDADILVVAVGIPGLITADHVADGAVVIDVGTTATADGQLLGDVD 243 Query: 246 FEDAAKRASYITPVPGGVGPMTVATLIENTLQAC-VEYHDPQDE 288 RA +TPVPGGVGP+T A L+ +T+ A +Y + E Sbjct: 244 AAAVDGRAGALTPVPGGVGPVTTALLLNHTVDAAGTQYAQTRSE 287 >UniRef50_C2L112 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Oribacterium sinus F0268 RepID=C2L112_9FIRM Length = 281 Score = 300 bits (768), Expect = 4e-80, Method: Composition-based stats. Identities = 94/276 (34%), Positives = 139/276 (50%), Gaps = 4/276 (1%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 + GK +A+++ E V P LA++ VG A Y + +K G Sbjct: 4 LLGKPVAEEIEKEC---VAFLAERPGVMPALALIRVGERTADVTYEKAIKKRFLSFGLEV 60 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 +SY LP S + E+I LN D I GI+V PLP+ +D I +KDV+G Sbjct: 61 KSYQLPADCSNEQFQEVIQFLNGDEEIHGIMVFRPLPSHLDQETAFRMIKREKDVEGVSR 120 Query: 126 YNV-GRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 N+ G + + PCT + ++ + Y I G ++G S +VGRP+S+ + Sbjct: 121 ENMAGLILKDESAFAPCTAQAVMEMCRFYKIPLAGKEVCILGRSLVVGRPLSILMTNKDA 180 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+ H T N++ + AD+L+ +GK I + KEGA VIDVG NR E G +VGDV Sbjct: 181 TVTLCHSKTSNIKEVTKRADVLVCCMGKAKAIGSSYCKEGATVIDVGTNRDEKGNLVGDV 240 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 F+ A A I+PVP G+G +T A L + L+A Sbjct: 241 DFDTMATVAEKISPVPRGLGAVTTAVLAKQLLKAYR 276 >UniRef50_UPI00006CCCC6 methylenetetrahydrofolate dehydrogenase n=1 Tax=Tetrahymena thermophila RepID=UPI00006CCCC6 Length = 342 Score = 299 bits (767), Expect = 5e-80, Method: Composition-based stats. Identities = 110/283 (38%), Positives = 165/283 (58%), Gaps = 9/283 (3%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQ--ARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACE 59 + + +G A+++ S + ++++ + + R PGL ++LVG+NPAS Y+ K +ACE Sbjct: 15 STVVFNGNKSAKKILSSLRKEIEWFQKQSDLSRKPGLGIILVGNNPASLSYIKKKLQACE 74 Query: 60 EVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKD 119 +G Y E E ++L ID LN + ID I+ QLPLP+ ID V+ I +KD Sbjct: 75 AIGIRHELYHFSEDIQEYDVLSAIDNLNRKDDIDAIMAQLPLPSHIDKNNVINMISSEKD 134 Query: 120 VDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 DG N L + PCTP + +LE + I + V+IG +VG+P+ L Sbjct: 135 ADGL-KLNSNNL-DPKANILPCTPAACLKILEEHQICLKDKHVVLIGRGRLVGQPLEQLL 192 Query: 180 LL-AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINR---- 234 + T + T +++ H+ AD++I A G+ I G WIK+GAIV+DVG+N+ Sbjct: 193 SKLSPAQITTCVKETGDIKQHILKADVIIAAAGERQLIKGKWIKKGAIVLDVGVNKGIPG 252 Query: 235 LENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 ++ KVVGDV FE+A KRAS ITPVPGG+GPMTV+ L+ NT+Q Sbjct: 253 IDPTKVVGDVEFEEAKKRASLITPVPGGIGPMTVSMLMYNTVQ 295 >UniRef50_B2KB67 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Elusimicrobium minutum Pei191 RepID=FOLD_ELUMP Length = 288 Score = 299 bits (766), Expect = 7e-80, Method: Composition-based stats. Identities = 99/286 (34%), Positives = 153/286 (53%), Gaps = 8/286 (2%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I++GKT+A +R + + Q R L + ++ AS +Y+ + KA E+ G Sbjct: 2 ILEGKTLAAAIRENLPARAQICKTKLGRPLKLTGIGWAADYASYVYLDKEIKAAEKTGIT 61 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 D+ E TS E+L +I L+ D T+D ++V PLP ++ +++ E ++P KD+DG Sbjct: 62 GEVIDITEQTSHEEMLNIIKKLSTDETVDAVIVPKPLPRHLNTLEIWEALNPLKDIDGSS 121 Query: 125 PYNVGRLCQRAP--------RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMS 176 N+GRL P T ++ LL+ Y I G+ V+G S VG+P++ Sbjct: 122 VLNMGRLFMCKNWAEVEAMQGFAPATAMAVIKLLDFYKIKLSGVETGVLGRSATVGKPLA 181 Query: 177 MELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE 236 L T + H T +L + D++I A+GK F+ + +K GA+VIDVG N+ E Sbjct: 182 HMLSCKDATVKICHSKTPSLTSSLSQCDIVISAIGKAKFVTENMVKTGAMVIDVGTNQDE 241 Query: 237 NGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 NG GDV FE+ K S ITPVPGGVGP+T+A L+EN + + Sbjct: 242 NGVFCGDVDFENVKKITSAITPVPGGVGPVTLACLLENIIISGERK 287 >UniRef50_D1ITY4 Whole genome shotgun sequence of line PN40024, scaffold_5.assembly12x (Fragment) n=1 Tax=Vitis vinifera RepID=D1ITY4_VITVI Length = 271 Score = 298 bits (763), Expect = 2e-79, Method: Composition-based stats. Identities = 124/287 (43%), Positives = 160/287 (55%), Gaps = 44/287 (15%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A IIDGK IAQ +RSE+A++V+ + PGLAVV+VG+ SQ YV+ KRKAC EVG Sbjct: 9 ASIIDGKAIAQAIRSEIAEEVRHLSEKYGKVPGLAVVIVGNRKDSQSYVSMKRKACAEVG 68 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 S DLPE E+EL+ + LNA + GILVQLPLP I+ KVL I +KDVDG Sbjct: 69 IKSFDVDLPEQVLESELIGKVHELNALPDVHGILVQLPLPKHINEEKVLSEISLEKDVDG 128 Query: 123 FHPYNVGRLCQR--APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 FHP N+G+L + P PCTP+G + LL R I Sbjct: 129 FHPLNIGKLAMKGREPLFLPCTPKGCLELLSRSGISV----------------------- 165 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-- 238 K+ + +AD++I A G+ I G WIK GA VIDVG N + + Sbjct: 166 -------------KDPESIIRDADIVIAAAGQAMMIKGSWIKPGAAVIDVGTNAVNDPSK 212 Query: 239 ----KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 ++VGDV F++A K A ++TPVPGGVGPMTVA L++NTL Sbjct: 213 KSGYRLVGDVDFQEACKVAGWVTPVPGGVGPMTVAMLLKNTLDGAKR 259 >UniRef50_B9K850 Bifunctional protein folD n=1 Tax=Thermotoga neapolitana DSM 4359 RepID=B9K850_THENN Length = 284 Score = 296 bits (759), Expect = 5e-79, Method: Composition-based stats. Identities = 98/279 (35%), Positives = 151/279 (54%), Gaps = 14/279 (5%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 ID K+IA+ + +V ++V P L V+ +P++ Y+ S++K E++G Sbjct: 16 IDCKSIAKSIEEDVRKRVDLL----SFTPKLVSVVGTDDPSTASYLRSQKKKAEKLGIDF 71 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 TS + L ++ L D ++G+ V PLP G+D +V + +KDV+G +P Sbjct: 72 EIIK----TSPGDFLSTLEKLAEDKNVNGVFVARPLPEGLDEKRVFSAVPVEKDVEGVNP 127 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG-- 183 N+G L PCT +V +LE + G ++G S VG+P+++ LL G Sbjct: 128 ENLGFLLYGEETFPPCTAEAVVKVLESV-TEISGKKVTIVGRSVTVGKPLAIMLLKKGRD 186 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T TV H T+NL +D+++VAVGK F+ D +KEGAIVIDVGIN + +GK GD Sbjct: 187 ATVTVCHSRTQNLGEITRASDIVVVAVGKAHFLKRDMVKEGAIVIDVGINYV-DGKWCGD 245 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 V A + + +TPVPGGVG +T A L E+ ++A Sbjct: 246 VD--SAVEEIAQVTPVPGGVGQITTALLFEHVVRAAERQ 282 >UniRef50_A0DMT9 Chromosome undetermined scaffold_57, whole genome shotgun sequence n=2 Tax=Paramecium tetraurelia RepID=A0DMT9_PARTE Length = 309 Score = 294 bits (754), Expect = 2e-78, Method: Composition-based stats. Identities = 107/258 (41%), Positives = 150/258 (58%), Gaps = 4/258 (1%) Query: 23 VQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLEL 82 ++ + + L PGLA++ VG+NP+S YV K CEE Y PET S+ E++ Sbjct: 26 LKIKENSALMRPGLAIIQVGNNPSSLTYVRKKIALCEEHQIHHELYHFPETISQKEIVHR 85 Query: 83 IDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQR--APRLRP 140 I +LN +IDGILVQLPLP + +++ I +KD+D H N L Q + P Sbjct: 86 IKSLNQKGSIDGILVQLPLPPHLSRLEISNEIKLNKDIDCLHMANFQNLLQNGEDNDIIP 145 Query: 141 CTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHV 200 CTP ++ +L+ NID N VIG S +VG P+S+ LL T+ H T ++ HV Sbjct: 146 CTPAAVLHILDTQNIDVRNQNVTVIGRSQLVGFPLSVLLLKRNARVTICHSET-TVQEHV 204 Query: 201 ENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE-NGKVVGDVVFEDAAKRASYITPV 259 E AD++I G + G+WIK GA VIDVGI R+ ++VGD+ F+ A R S+ITPV Sbjct: 205 EKADIVISCAGHKELVKGEWIKNGAKVIDVGITRIPGTNQIVGDIEFQKALPRVSFITPV 264 Query: 260 PGGVGPMTVATLIENTLQ 277 PGGVGP+TV+ L N + Sbjct: 265 PGGVGPLTVSMLFRNLYR 282 >UniRef50_A5ILJ9 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=Thermotogaceae RepID=FOLD_THEP1 Length = 271 Score = 294 bits (754), Expect = 2e-78, Method: Composition-based stats. Identities = 96/280 (34%), Positives = 149/280 (53%), Gaps = 14/280 (5%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 ID +TIA+ + ++V+ P L V +P++ Y+ S+RK E++G Sbjct: 3 IDCRTIARSIEERTKERVEKL----GFTPKLVSVACTDDPSTLSYLKSQRKKAEKLGIAF 58 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 S E++ + L +D +++G+ V P P D ++L + +KDV+G +P Sbjct: 59 EIL----NVSPEEIVSTLKKLGSDESVNGVFVARPFPPSFDEKEILSSVPVEKDVEGVNP 114 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG-- 183 N+G L PCT V +LER + G V+G S VG+P+++ LL G Sbjct: 115 ANLGLLLYDEEIFPPCTAEAAVRILER-ETNLSGKRVTVVGRSVTVGKPLALMLLKKGRD 173 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T TV H T NL +N+D+++VAVG+ F+ + +KEGAIVIDVGIN + +GK+ GD Sbjct: 174 ATVTVCHSRTVNLEEITKNSDIVVVAVGRAHFLKKNMVKEGAIVIDVGINYV-DGKLQGD 232 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 V + A +TPVPGGVG +T A L E+ ++A Sbjct: 233 VD-PSVEEIAR-VTPVPGGVGQVTTALLFEHVVRAAERQR 270 >UniRef50_D2W298 Predicted protein n=2 Tax=Naegleria gruberi RepID=D2W298_NAEGR Length = 319 Score = 293 bits (751), Expect = 5e-78, Method: Composition-based stats. Identities = 114/303 (37%), Positives = 183/303 (60%), Gaps = 24/303 (7%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGL----RAPGLAVVLVGSNPASQIYVASKRKACEE 60 +I+G IA +++ E+ + ++ + R PGLAVV+VGS S YV K++AC E Sbjct: 12 LINGLEIAAEIKEEIKRDIERIVEKQKGGQVRRPGLAVVMVGSRKDSLTYVQRKQEACAE 71 Query: 61 VGFVS--RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDK 118 +G S ++ ++ ++ ++++ I NAD+ + GILVQLPLP+ ++ K+LE I P K Sbjct: 72 LGIESFKTHFEDDQSVTDEDVIKTIQQYNADDRVHGILVQLPLPSHLNEEKILESISPAK 131 Query: 119 DVDGFHPYNVGRLCQRAP------RLRPCTPRGIVTLLERY----NIDTFGLNAVVIGAS 168 DVDG ++ G + + PCTP GI+ ++ R N++ GL++VV+GAS Sbjct: 132 DVDGLTQFSFGLISMKGRKLVDGINFVPCTPLGIMEMIRRTAQKLNMNLEGLDSVVVGAS 191 Query: 169 NIVGRPMSMELLLA-GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIV 227 NIVG P ++ LL + + H ++N+ + AD+L+V G I +WIK+GAIV Sbjct: 192 NIVGIPTALVLLNQLQTSVQLLHIKSQNIPEKISKADILVVCCGCAEIIKPEWIKKGAIV 251 Query: 228 IDVGINRLENG------KVVGDVVFED-AAKRASYITPVPGGVGPMTVATLIENTLQACV 280 IDVG+ +E+ ++VGDV+F+D KRAS TPVPGGVGP+T+A+L++NT + + Sbjct: 252 IDVGLTPVEDKTQERGFRLVGDVLFDDNLKKRASAATPVPGGVGPVTIASLMKNTYHSFL 311 Query: 281 EYH 283 + Sbjct: 312 SKN 314 >UniRef50_B5IEC2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein n=2 Tax=Aciduliprofundum boonei T469 RepID=B5IEC2_9EURY Length = 273 Score = 291 bits (745), Expect = 2e-77, Method: Composition-based stats. Identities = 116/276 (42%), Positives = 169/276 (61%), Gaps = 10/276 (3%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 II+ KT+A+++R ++ + + L ++VG + AS +Y S K ++GF Sbjct: 2 IIECKTLAKEIRENAKKEAKGKKL------WLHNIVVGGDEASLVYARSNLKLLRKLGFD 55 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + + L E SE ELL+LI LN D+++ GI+V PLP ID +KV I P KDVDG + Sbjct: 56 GKIHHL-EEASERELLDLIQALNEDDSVHGIMVNFPLPDNIDPMKVRSTISPIKDVDGIN 114 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 P N G+L L P TPR ++ +LER + G + ++I + +VG+P+S+ LL Sbjct: 115 PINYGKLLLGEEILTPNTPRAVIRILER-ETELRGKDVLIINRTPVVGKPLSLLLLNRDA 173 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+ H T+NL+ AD+++VAVGKP F+ D + EGAI+IDVGIN + NGK+VGD Sbjct: 174 TPTIAHSKTRNLKEKALEADVIVVAVGKPKFLKEDMVHEGAIIIDVGINVV-NGKIVGDA 232 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 F+ K+A ITPVPGGVG +T A LIEN ++A Sbjct: 233 DFDSIEKKAK-ITPVPGGVGTVTNACLIENLVKAAK 267 >UniRef50_B7QFP4 C1-tetrahydrofolate synthase, putative n=1 Tax=Ixodes scapularis RepID=B7QFP4_IXOSC Length = 297 Score = 291 bits (745), Expect = 2e-77, Method: Composition-based stats. Identities = 107/255 (41%), Positives = 146/255 (57%), Gaps = 11/255 (4%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 ++IDGK IA ++ +E+ + + + G R P L VLVG + S +YV +K KA E G Sbjct: 32 EVIDGKRIANEIETEIRSAINSDLVHGGRRPHLCAVLVGDDEGSAVYVKNKIKASERTGI 91 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S + LP +T++ +LL LI LN +DGILVQLPLP I+ + + P KDVDGF Sbjct: 92 TSENIHLPSSTTQTDLLSLIKKLNESKFVDGILVQLPLPRHIEESVICNSVLPSKDVDGF 151 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA- 182 H +GRLC L PCTP IV +L+R ++T G + VV G S IVG P+S+ L A Sbjct: 152 HALQMGRLCLNMDSLAPCTPLAIVEILQRTGVNTTGKHIVVCGRSTIVGLPISIMLGSAR 211 Query: 183 ---GCTTTVTHRFT--KNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 T + H T +LR V AD+++ A G PG I + +K G VIDVGI R+ + Sbjct: 212 SYGNATVSCCHSHTSPSDLRALVGMADIVVTATGVPGLIMANMVKHGVCVIDVGITRVHD 271 Query: 238 G-----KVVGDVVFE 247 K+VGDV FE Sbjct: 272 SVTGKTKLVGDVDFE 286 >UniRef50_C1BVL5 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial n=2 Tax=Caligidae RepID=C1BVL5_9MAXI Length = 309 Score = 290 bits (744), Expect = 3e-77, Method: Composition-based stats. Identities = 114/299 (38%), Positives = 172/299 (57%), Gaps = 18/299 (6%) Query: 1 MAAKI---IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKA 57 MA I IDGK IA + + + +V++ ++ +P L +LVGS+PAS+IY+ K++A Sbjct: 1 MATSITRRIDGKAIANGILAGLKSEVESFVSKYGCSPKLVPILVGSDPASEIYLKRKQEA 60 Query: 58 CEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPD 117 ++G L E T+E ++ I LN D + GI+VQLPLP+ + +V E I+ Sbjct: 61 ASKIGIDCSIIRLHEKTTEESVISEICKLNQDPLVHGIIVQLPLPSEVREKEVCETINGL 120 Query: 118 KDVDGFHPYNVGRLCQR--APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPM 175 KDVD F ++G++ L PCTP + +++ ID G NAV++G S+ VG P+ Sbjct: 121 KDVDAFGLAHLGQIILNPLRSDLIPCTPLAVYKIIKSLEIDLSGKNAVILGRSHNVGMPI 180 Query: 176 SMELLLA------GCTTTVTHRFTK--NLRHHVENADLLIVAVGKPGFIPGDWIKEGAIV 227 ++ L TTT+ HR T L V+ AD+++ AVGKPG D IK+GA++ Sbjct: 181 ALLLAADHIKGGFNMTTTICHRATPPEELEVAVKRADVIVSAVGKPGLARRDMIKKGAVI 240 Query: 228 IDVGINRLENG----KVVGDVVFEDAAK-RASYITPVPGGVGPMTVATLIENTLQACVE 281 +DVGI R+++ K+ GDV AS++TPVPGGVGP TVA L+ NT++A Sbjct: 241 VDVGITRVKDKDDRYKLFGDVDPLVLMDGIASHMTPVPGGVGPCTVACLMHNTVRAAYN 299 >UniRef50_Q54VK0 Methenyl tetrahydrofolate cyclohydrolase / NADP-dependent methylene H4F dehydrogenase n=1 Tax=Dictyostelium discoideum RepID=Q54VK0_DICDI Length = 440 Score = 290 bits (743), Expect = 3e-77, Method: Composition-based stats. Identities = 106/301 (35%), Positives = 161/301 (53%), Gaps = 20/301 (6%) Query: 6 IDGKTIAQQV---RSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 +DGK +A + + + + I P L V+ VG + + Y+ +KR CE+VG Sbjct: 86 LDGKLLASHIVSSKKSIKADTEDFIKNSGVTPNLVVIYVGDSKQIESYIKAKRTGCEDVG 145 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 F E +L++ I + D ++ GI+VQLPLP ++ +++ I P KDVDG Sbjct: 146 FKFTLDRFSSDIKEDQLIKKIKYHSEDPSVHGIIVQLPLPDNLNKDAIIQSIDPKKDVDG 205 Query: 123 FHPYNVGRLC-QRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 N+G++ + P PCTP GI+ +L+ Y I G N VV+G SN+VGR ++ L Sbjct: 206 LTSTNLGQIMISKKPLYIPCTPLGILEILKAYKIKVEGKNVVVLGRSNLVGRTIATILSQ 265 Query: 182 A---------GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGI 232 G T+ H+++KN + ADL+I A G PG I + +K G I+IDVGI Sbjct: 266 KDLTNPSIMNGANVTIIHKYSKNHLGSIRQADLIISATGVPGLIKKEDLKRGVILIDVGI 325 Query: 233 NRLENG------KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 + E+ K+VGD+ E A R+ TPVPGGVGP+TVA L+ N L++ + + Q Sbjct: 326 SFKEDSTKKSGYKMVGDIDPE-AYSRSIAYTPVPGGVGPLTVACLLRNVLRSAILQYRIQ 384 Query: 287 D 287 Sbjct: 385 S 385 >UniRef50_Q0AWX5 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Syntrophomonas wolfei subsp. wolfei str. Goettingen RepID=FOLD2_SYNWW Length = 272 Score = 290 bits (743), Expect = 3e-77, Method: Composition-based stats. Identities = 105/271 (38%), Positives = 157/271 (57%), Gaps = 7/271 (2%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 +I GK I +Q++ V Q + GLA++ VG +P+S YV RK EE G Sbjct: 2 LIYGKDIREQIKERVRQSAEEVKM------GLAIIRVGDDPSSMAYVRGIRKFAEETGVK 55 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 +LP+ E ELL+ I LN + I GI++Q PLPA ++ ++ I DKDV+G H Sbjct: 56 VEIVNLPDAVGERELLKTIGDLNNSSEITGIMLQTPLPASLNASHLVNAIDFDKDVEGIH 115 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 YN+G+L + +RPCTP+ ++++L+ ++I G +IG S VG P+++ + Sbjct: 116 NYNLGKLISKEEGVRPCTPKAVISMLKAHDILIEGQKVTIIGRSMTVGSPLALMMTAENA 175 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T TV H T+NL+ AD+L+ AVGK F+ D + + +VIDVGIN ENGK++GDV Sbjct: 176 TVTVCHTRTRNLKEEALRADILVAAVGKREFVTADMVHKDMVVIDVGINFDENGKMLGDV 235 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENT 275 E+A + VPGG+G +TVA L +N Sbjct: 236 -HEEARNHCRLASAVPGGIGVITVAELFDNL 265 >UniRef50_A0C3Q0 Chromosome undetermined scaffold_147, whole genome shotgun sequence n=2 Tax=Paramecium tetraurelia RepID=A0C3Q0_PARTE Length = 404 Score = 289 bits (739), Expect = 1e-76, Method: Composition-based stats. Identities = 106/274 (38%), Positives = 158/274 (57%), Gaps = 16/274 (5%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I +G +A + + + P L + LVG +PAS+ YV K KAC+E+ Sbjct: 119 IFNGNQLANTILKTLRITSE-------IKPKLGICLVGDSPASKSYVNRKLKACQEINVD 171 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + ++ E + +L++ I +N D GILVQLPLP+ ++ + ++ I +KDVD H Sbjct: 172 AEVFNFSENVGQEQLIKHIQQMNHD----GILVQLPLPSHLNKLDIIHSIPYEKDVDCLH 227 Query: 125 PYNVGRLCQRAP--RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 +N+ R+ + PCTP ++ +L+ Y+++ G +IG S +VG P+S+ L Sbjct: 228 MHNLQRILVYGELCEMLPCTPAAVLQILDYYDVNVIGKKVTMIGRSFLVGLPLSLLLQKR 287 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE-NGKVV 241 T TV HR T NL H+ NAD++I A G P + +K+GAIVIDVGI++ E GK+V Sbjct: 288 NATVTVCHRETLNLDQHIMNADIVISAAGHPKLVRN--VKQGAIVIDVGISQGEKKGKIV 345 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENT 275 GDV F+ +AS ITPVPGGVGPMTV L+ N Sbjct: 346 GDVDFDVVKNQASLITPVPGGVGPMTVCMLMRNL 379 >UniRef50_A4X776 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=Bacteria RepID=FOLD1_SALTO Length = 306 Score = 287 bits (734), Expect = 4e-76, Method: Composition-based stats. Identities = 101/278 (36%), Positives = 157/278 (56%), Gaps = 7/278 (2%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A+ + G +A+Q+ +EVAQ+V AAG+ P LA VLVG + AS Y+ K++ ++G Sbjct: 8 ARSLPGGPVAEQILAEVAQEVTQLRAAGV-TPALATVLVGDDDASVGYIRIKQRQAVQLG 66 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 F S LP + S+A+L ++ L+AD ++ G+LVQ P+P +D + ++ + P+KDVDG Sbjct: 67 FASPHVRLPASASQADLQAVVTQLSADTSVHGVLVQHPVPPHLDFDRAMQALDPEKDVDG 126 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 HP N+GRL P PCTP GI LL + + G VV+G +GRP++M L Sbjct: 127 MHPVNLGRLALGLPGPTPCTPAGIEALLAYHEVPVAGREVVVLGRGATLGRPLAMVLAQK 186 Query: 183 ----GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 TV H + + A++++ A G PG + + ++ GA+V++ G+ R Sbjct: 187 RPTANAAVTVVHTGVPDWPRYTRRAEIVVAAAGVPGLVRPEHLRPGAVVVNGGV-RYAGR 245 Query: 239 KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 +++ DV E A A +TP GGVGP TVA L N + Sbjct: 246 RLLPDVD-ESCATVAGAMTPRVGGVGPTTVAMLFRNAV 282 >UniRef50_B9CK25 Bifunctional protein FolD n=1 Tax=Atopobium rimae ATCC 49626 RepID=B9CK25_9ACTN Length = 285 Score = 284 bits (728), Expect = 2e-75, Method: Composition-based stats. Identities = 86/282 (30%), Positives = 136/282 (48%), Gaps = 3/282 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A+ + G +A + ++ + A G+ P LA++ +G Y + K E++ Sbjct: 1 MAEELRGAPVAAALTEALSVRAAALADRGV-TPTLAILRLGERSDDLAYERAALKRAEKI 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G R L S+ ++ E I +++D I L P P I+ + P KDVD Sbjct: 60 GIAVRQTVLSRNASQHDVDETIRDISSDPHIHACLPLRPFPKTINEAGAFALLSPSKDVD 119 Query: 122 GFH-PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 + L R+ L PCT ++ +L+ Y I+ G A V+G SN++GRP++ L Sbjct: 120 CVTDSMLLATLSGRSCALAPCTAEAVIAILDHYGIEIAGARAAVVGRSNVIGRPVAALLT 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-K 239 + T T+ H T +L A++L+VA G+ I ++ G VIDVGIN E K Sbjct: 180 MRDATVTLCHSRTVDLPSVTCEAEILVVAAGRARMIDSGYVAPGQTVIDVGINWDEASQK 239 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 +VGDV E + TPVPGGVG +T A L ++ ++A Sbjct: 240 LVGDVDAEAIKDTVAAYTPVPGGVGSVTTAILAKHVIEAAER 281 >UniRef50_Q86F84 Clone ZZD1003 mRNA sequence n=2 Tax=Schistosoma japonicum RepID=Q86F84_SCHJA Length = 332 Score = 284 bits (728), Expect = 2e-75, Method: Composition-based stats. Identities = 94/297 (31%), Positives = 147/297 (49%), Gaps = 22/297 (7%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+ G+ +AQ V ++ V ++ P L V+ VG P S++Y+ K K ++ G + Sbjct: 6 ILYGRQVAQAVGHKIKLDVALLKSSFDVYPKLVVIEVGELPQSKLYIKQKFKFAKKYGIL 65 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPA--GIDNVKVLERIHPDKDVDG 122 LP SE+ LL+ + LNAD+++ GI +QLP + I+ L + KDV+G Sbjct: 66 LSHMRLPSHISESLLLDYVYKLNADSSVHGITLQLPFDSDTNINVTNSLNAVATHKDVEG 125 Query: 123 FHPYN------------VGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNI 170 + YN + RL + CT L+ N G V+IG + Sbjct: 126 LNSYNTALLSVVIYSATLRRLKTKTYSYT-CTAAACYALIRHVNFPISGSRCVIIGRGRL 184 Query: 171 VGRPMSMELLLA-GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVID 229 VG P + L + G T H + N+ + D++I VG PG I GDW++ GA+VID Sbjct: 185 VGAPTAELLSGSCGATVIQCHLQSANIDEEINRGDIIISGVGHPGLIKGDWVRPGALVID 244 Query: 230 VGINRLEN------GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 G + + + + GDV F A ++A +ITPVPGGVGP+++A L NT+ + Sbjct: 245 CGYSVMNDPQNPSKSRCFGDVEFNTALEKAKWITPVPGGVGPVSIAMLFRNTVNSAQ 301 >UniRef50_C1MLD7 5,10-methylene-tetrahydrofolate dehydrogenase/cyclohydrolase n=1 Tax=Micromonas pusilla CCMP1545 RepID=C1MLD7_9CHLO Length = 405 Score = 282 bits (723), Expect = 8e-75, Method: Composition-based stats. Identities = 120/352 (34%), Positives = 164/352 (46%), Gaps = 75/352 (21%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A+ +DG+ A + E+A + R PGLA ++VG+ P S +YV K +AC++ G Sbjct: 56 ARHLDGRQHAIRWMREIA----ISASRNPRPPGLAAIVVGNRPDSLLYVRRKGEACKKTG 111 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 LP + ++ +++ LN+D IDGILVQLP+P I K+LE I P+KDVDG Sbjct: 112 IHFYLIHLPGDIRQGKVRQILRRLNSDKNIDGILVQLPMPPQITENKLLECISPEKDVDG 171 Query: 123 FHPYNVGRLCQR---APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 HP NVGRL R P PC P G + LL R I+ VIG SNIVG P+S L Sbjct: 172 LHPKNVGRLSARGTWRPVFMPCAPLGCMELLWREKINVKKKAVTVIGDSNIVGMPLSWLL 231 Query: 180 LLAGC-TTTVTHRF------------------------TKNLRHHVENADLLIVAVGKPG 214 AG + T+ H + H + AD++I AVG G Sbjct: 232 RDAGASSVTILHSRAIWFLDKFSTAGSDDSQLCEDKPLQAQILHSLCEADVVIAAVGSVG 291 Query: 215 FIPGDWIKEGAIVIDVGIN----------------------------------------- 233 + +WIKEGA V+D+GIN Sbjct: 292 LVKREWIKEGATVVDIGINAVPDCHESVIFTGISPQKDCVNVCSSVTAMQRDAQQSFRSV 351 Query: 234 --RLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 L N K++GDV E+ + A +T VPGG GPMT+A L+ NT + H Sbjct: 352 PQPLRNFKILGDVAAEEVSHVAGAMTSVPGGAGPMTIAALLSNTCLSASRKH 403 >UniRef50_C8WN84 Tetrahydrofolate dehydrogenase/cyclohydrolase n=1 Tax=Eggerthella lenta DSM 2243 RepID=C8WN84_EGGLE Length = 289 Score = 282 bits (722), Expect = 9e-75, Method: Composition-based stats. Identities = 85/276 (30%), Positives = 139/276 (50%), Gaps = 2/276 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A+++ GK + + ++ +++A P LA+V VG P Y + RK E + Sbjct: 1 MAELLKGKPVVDSMALDLRARIEAL-GRAKVVPALALVRVGQRPDDLSYERTARKRAESL 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G R Y+L E +A + I +N D + G L+ PLP+ +D + E + P KD+D Sbjct: 60 GIAIRPYELDEFAPQAAIEAAIHEVNRDENVHGCLLFRPLPSFVDESHMCELLDPKKDID 119 Query: 122 GFHPYNVGRLC-QRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 G ++ + P T + LL+ Y + G + VV+G S +VG+P+SM LL Sbjct: 120 GITLASLASVFTDGHAGYPPATAAACIQLLDHYQVPLQGKHVVVVGRSLVVGKPVSMMLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 + T+ H T+NL + +AD++I A G+ + G V+DVGIN G + Sbjct: 180 RRNASVTICHSKTENLADIMRSADVVICATGRARTFGAQFFGPGQTVLDVGINFDTQGNL 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 GDV F + + ITPVPGG+G +T + + +T+ Sbjct: 240 CGDVDFAEVEPVVAAITPVPGGIGTVTTSVTMAHTV 275 >UniRef50_Q04FB7 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=Leuconostocaceae RepID=FOLD_OENOB Length = 285 Score = 280 bits (718), Expect = 3e-74, Method: Composition-based stats. Identities = 110/287 (38%), Positives = 157/287 (54%), Gaps = 9/287 (3%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +I+DG+++++++ EV KV A LA + N S++YV K + G Sbjct: 3 QILDGRSVSKKILQEVKDKV----AKAGFPVKLATIYNEENEGSKMYVGMKIRRATFAGL 58 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 +S Y + + ++L L+ LN D++I GILVQ PL GID K+ I P KD DG Sbjct: 59 ISVEYKVDNSWKTDDILRLLSKLNMDSSICGILVQSPLGDGIDESKIFNAIDPLKDADGL 118 Query: 124 HPYNVGRLCQR--APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 +N G L + + P TP G+++LLE Y+ NA+V+G S + GRPMS+ L Sbjct: 119 SAFNQGLLFENAKENYIVPATPAGVISLLEAYHYQFAAKNALVVGRSVLFGRPMSVLLTN 178 Query: 182 AGCTTTVTHRFTK--NLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGK 239 T T+ H T LR + ADL++VA+GK + +K+ +VIDVG N+L NG Sbjct: 179 RDMTVTLAHSKTPVDQLRQFAKRADLIVVAIGKANWFQFTDLKKDVVVIDVGANKL-NGH 237 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 GDV FE S I+PVPGGVGPMT+ATLI++T V Q Sbjct: 238 ATGDVDFEKVYPHVSQISPVPGGVGPMTIATLIKHTFDLAVFQQGEQ 284 >UniRef50_UPI00003C8447 methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI00003C8447 Length = 281 Score = 279 bits (715), Expect = 7e-74, Method: Composition-based stats. Identities = 95/272 (34%), Positives = 150/272 (55%), Gaps = 4/272 (1%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 ++DGK +A + + +++ I P L ++ VG++PAS IY SK K ++G Sbjct: 2 LLDGKVVASEKMERLKSEIKGIIEKYGIEPELKLIQVGNDPASTIYANSKIKRGTKLGIN 61 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + +L++ I NA++ I+GI+V+ PLP ++ +V++ I KD DG Sbjct: 62 VTLEKFD-NITMGKLVDYIKDANANSRINGIMVESPLPPSLNFQEVVDNISFYKDTDGMT 120 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 +N G L + + P T R +V +LE Y I NA +I S +VGRP++M LL Sbjct: 121 SFNQGNLYTKNEMIAPATARAVVDILEYYKIQPG--NACIINRSAVVGRPLAMLLLNRDY 178 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+ H T +++ ++L+VA+GKP +I ++ + VIDVGIN N K+ GDV Sbjct: 179 TVTLCHSKTVDIKRIARENNVLVVAIGKPDYIDESYVTSESTVIDVGINYSGN-KISGDV 237 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 F+ + +A ITPVPGGVG +T + EN L Sbjct: 238 NFDSVSNKAKNITPVPGGVGIVTATDIFENFL 269 >UniRef50_Q2JCX4 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=Frankia RepID=FOLD1_FRASC Length = 276 Score = 279 bits (714), Expect = 8e-74, Method: Composition-based stats. Identities = 102/277 (36%), Positives = 152/277 (54%), Gaps = 4/277 (1%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +++DG+++A ++ V + + AAG+ P LAVVL ++PA+ Y + +VG Sbjct: 2 RMLDGRSMAAEIGRYVVDEAERLAAAGV-TPTLAVVLPTADPAAYSYAEIIERTAGKVGV 60 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 ++ A +L+ IDT+ AD T+ GI+VQ PLP G+ + +V E I KDVDG Sbjct: 61 HCVLHE--PKGEPAAILDTIDTVAADPTVHGIIVQTPLPGGLTSREVGEHIPTAKDVDGM 118 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 +P ++GRL P P T +V +L R I G VIG +VG+P+S+ LL Sbjct: 119 NPSSLGRLALGLPSFAPATAAAVVEILTRARIPMSGARVCVIGRGPVVGKPVSLLLLAED 178 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T T+ H TK L AD+++ A G P + +++ GA VIDVG E G+ VGD Sbjct: 179 ATVTICHSRTKGLVSIAHEADIIVSATGHPRLVGAGFVRPGAAVIDVGTVVTETGQ-VGD 237 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 V + A +TPVPGGVGP+T L+ NT++A Sbjct: 238 VDAAAVSSVAGALTPVPGGVGPVTTMLLLRNTIRAAR 274 >UniRef50_Q1AVQ0 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Rubrobacter xylanophilus DSM 9941 RepID=FOLD2_RUBXD Length = 320 Score = 278 bits (713), Expect = 1e-73, Method: Composition-based stats. Identities = 110/296 (37%), Positives = 151/296 (51%), Gaps = 20/296 (6%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A++IDG+ IA +++ VA +V+ A G+R PGLA VLVG + A++ Y E Sbjct: 1 MGARVIDGRPIAGELKKRVASEVEGLAARGVR-PGLATVLVGEDYAARAYERRVGGLAAE 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G LP EA++L ++ LNAD + GILV PLP I V + P KD+ Sbjct: 60 LGCRYVCERLPREAEEADVLAVVGKLNADPRVSGILVLRPLPGHISEPAVFSALDPLKDI 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGL---------NAVVIGASNIV 171 + HP N G L PR P TP LL+RY ++ G VV+G SN V Sbjct: 120 EAVHPVNAGLLALGRPRYVPSTPAACFYLLDRY-LERSGRPPEEFYPRSTVVVVGRSNNV 178 Query: 172 GRPMSMELLLAGCTTTVTHR---FTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVI 228 G+P G LR H AD LIVA G G I +++EG I + Sbjct: 179 GKPAVSLGFARGAAVISCDANAYRAGRLREHTLKADALIVAAGVAGLIDESYVREGVIAV 238 Query: 229 DVGINRLENGK------VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 DVGIN + + +VGD+ F A++A +TPVPGGVGP+T L++NT+ A Sbjct: 239 DVGINPVADPGGSGRTLLVGDLDFGSVARKAEALTPVPGGVGPITDVWLLKNTVAA 294 >UniRef50_C8WUM8 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WUM8_ALIAD Length = 285 Score = 278 bits (712), Expect = 1e-73, Method: Composition-based stats. Identities = 86/275 (31%), Positives = 145/275 (52%), Gaps = 2/275 (0%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 K + G+ +A+ + +V + V+ + G++ P L +L + A+ +Y K++ E +G Sbjct: 3 KPLLGRPVAKALSHDVRKTVETWKSRGVQ-PKLVTLLANDDHAASVYANQKKRIAERLGI 61 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 +LP+ + ++ I LN D ++ GI++++PL +D +V+ IH KDVDG Sbjct: 62 QCDVIELPQQSDTEAIVRQIQALNDDPSVHGIMIEMPLAPSVDVQRVVGAIHALKDVDGL 121 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 P + L P TP + LL+ Y G + ++G VG P+ L+ G Sbjct: 122 SPCHSFAKPTPEAALYPATPLACIRLLKHYGYQLKGADVTLVGCGQTVGMPLLHLLIAEG 181 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T H T+++R H+ ++++ IVAVGK G + D + +G V+DVGI++ ENG V GD Sbjct: 182 ATVAACHEHTRDVRAHLRDSEIAIVAVGKGGLLGPDMVHDGLTVVDVGISQGENGDVQGD 241 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 + E AA + TP PGGVG +T + N + A Sbjct: 242 LAPEAAA-KTKAYTPTPGGVGAVTTVQIFANLMHA 275 >UniRef50_C4QA37 Formate-tetrahydrofolate ligase, putative n=1 Tax=Schistosoma mansoni RepID=C4QA37_SCHMA Length = 335 Score = 277 bits (709), Expect = 3e-73, Method: Composition-based stats. Identities = 98/302 (32%), Positives = 148/302 (49%), Gaps = 22/302 (7%) Query: 1 MAAKI-IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACE 59 M+ I + G+ IAQ V ++ V + +P L VV VG+ P S++Y+ K K + Sbjct: 2 MSKGITLCGQQIAQTVGQKIISDVAYLKSNFNISPKLVVVEVGNLPQSKLYIEQKSKFAK 61 Query: 60 EVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPL--PAGIDNVKVLERIHPD 117 + G + P E+ LL+ + LN+D+++ GI +QLP + I+ L + Sbjct: 62 KYGILLSHMRFPSHIPESVLLDYVYKLNSDSSVHGITLQLPFDSDSNINVTNPLNAVATL 121 Query: 118 KDVDGFHPYNVGRLCQR------------APRLRPCTPRGIVTLLERYNIDTFGLNAVVI 165 KDV+G +PYN L + PCT + N G V+I Sbjct: 122 KDVEGLNPYNTAVLSRGDILCPYCENVKQQHVHIPCTAAACYAFIRHVNFPIIGSRCVII 181 Query: 166 GASNIVGRPMSMELLLA-GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEG 224 G +VG P + L + G T H + N+ + D++I AVG P I G+WIK G Sbjct: 182 GGGRLVGAPTADLLSRSCGATVIQCHIQSNNINEEINRGDVVISAVGHPRLIKGEWIKPG 241 Query: 225 AIVIDVGINRLEN------GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 A+VID G + L + + VGDV FE A + A +ITPVPGGVGP+++A L NT+ + Sbjct: 242 ALVIDCGYSVLNDPRNPNKSRCVGDVEFETAIENAKWITPVPGGVGPVSIAMLFRNTVNS 301 Query: 279 CV 280 Sbjct: 302 AK 303 >UniRef50_B5Y9D1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=FOLD_COPPD Length = 273 Score = 277 bits (709), Expect = 3e-73, Method: Composition-based stats. Identities = 103/282 (36%), Positives = 148/282 (52%), Gaps = 12/282 (4%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A I+ GK +A + E+ + G+ GS+ Y++ KA + + Sbjct: 1 MALIMKGKPVADAIYEELQPMTSLNLTLGIIK------YKGSDAG--GYLSGLSKAAQRL 52 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 R E EL + + + D+ + GIL+ P P + + + I P+KDVD Sbjct: 53 NVQLRV---NEVEQFQELTQSVVVMGKDSQVHGILLLKPFPKEWNFRQASDLIPPEKDVD 109 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNI-DTFGLNAVVIGASNIVGRPMSMELL 180 HP N+G+L Q L P TP+ ++++L+ YN+ G +A+VIG S VG P ++L+ Sbjct: 110 ALHPVNLGKLAQGRGNLVPATPQAVLSILDFYNVLPLEGASALVIGRSEAVGLPAFLQLM 169 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T TV H TK+L ADL++VAVGKP F+ D +KEGA+VIDVG N LE+GKV Sbjct: 170 QRNATVTVAHSRTKDLPSLSRQADLVVVAVGKPNFLTKDHVKEGAVVIDVGTNVLEDGKV 229 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 VGDV E+ ITPVPGGVG +T A L +N E Sbjct: 230 VGDVDRENVEPLVRAITPVPGGVGSVTTACLFKNLFLCYQEQ 271 >UniRef50_Q6L046 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Picrophilus torridus RepID=FOLD_PICTO Length = 276 Score = 275 bits (705), Expect = 9e-73, Method: Composition-based stats. Identities = 92/272 (33%), Positives = 150/272 (55%), Gaps = 6/272 (2%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 IIDG I++ + +++ G+ P + ++L+G++ S +Y +K + ++G Sbjct: 2 IIDGVKISETKMERLKNEIEKIKNTGIN-PKMKIILIGNDYGSVVYSKAKMRRGSKLGID 60 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + S +L++L+ + + I GI+++ P+P GI+ V+ I KDVDG Sbjct: 61 VDLDRYD-SISREDLIKLLKRYSQSDDIHGIMIETPVP-GINYYDVVNEIPFYKDVDGMT 118 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 YN+G L + + P T R +V +L+ I+ N +I S +VGRP+SM LL Sbjct: 119 SYNLGNLYLKNEFIAPATARAVVDILDY--INIKSGNVAIINRSPVVGRPLSMMLLNRDF 176 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T TV H T N+ ++D+++VAVGKP F+ ++ + I+IDVGIN L NGK GD Sbjct: 177 TVTVCHSRTVNINEITRSSDIVVVAVGKPNFLDRSYVSDKNIIIDVGINYL-NGKTCGDA 235 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 +E+ + ITPVPGGVGP+T + EN + Sbjct: 236 DYENIKDYVNAITPVPGGVGPVTATDIFENFI 267 >UniRef50_Q160C0 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=Alphaproteobacteria RepID=FOLD3_ROSDO Length = 290 Score = 275 bits (705), Expect = 1e-72, Method: Composition-based stats. Identities = 93/283 (32%), Positives = 151/283 (53%), Gaps = 8/283 (2%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +++ GK + R + ++V++ R L + +G P +YV ++ +A G Sbjct: 5 RLLMGKPV----RERILEEVRSVTEKVDRIGKLVSISIGDVPEVAVYVRNQARAASTAGL 60 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 ++ E +I +N D + GI++Q P+P I+ + IHP KDV+G Sbjct: 61 PFDQEFWGADVTQDECKAMIQKMNDDPEVLGIILQRPVPDHINVRSLQSAIHPLKDVEGM 120 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 +P ++G + + PCT V L+ + GL V++G S IVG+P +M L+ G Sbjct: 121 NPASIGNIVYNDVAMAPCTAAAAVELIRETGLKLEGLEVVMVGHSEIVGKPAAMMLMAEG 180 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE----NGK 239 T TV H T+++ H AD+++VAVGK I D +K GA VID+GIN++ N + Sbjct: 181 ATVTVCHHLTRSVAMHSRRADVIVVAVGKAHLIGADMVKPGAAVIDIGINQITEADGNTR 240 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 +VGDV + + A ++TPVPGGVGP+TVA L+ N ++A Sbjct: 241 IVGDVDTDAVKEIAGWVTPVPGGVGPVTVAILMRNAVRAHERQ 283 >UniRef50_C5CI88 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=FOLD_KOSOT Length = 277 Score = 275 bits (703), Expect = 2e-72, Method: Composition-based stats. Identities = 85/282 (30%), Positives = 144/282 (51%), Gaps = 12/282 (4%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 ++DGK +A+ + +E+ + + + P L + + +++ Y+ S K ++ Sbjct: 1 MGILLDGKPVAKMIYAEIKEWLGNLQE---KPPKLVLFCSEPDDSTKTYMNSIVKRGGKL 57 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G E E I LN + G+++ PL +D V+ + +KDV+ Sbjct: 58 GISVEICHAGENPVEE-----IKKLNESRDVAGVMIMHPL-KNVDEKLVVSALSLEKDVE 111 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G P N+G + P T ++ +L Y++ G + ++G S VG+P+SM +L Sbjct: 112 GRTPGNLGGIMTGDESFAPPTAEAVMEILRFYDVSLSGKDVTIVGRSTTVGKPLSMLMLK 171 Query: 182 AG--CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGK 239 G T T+ H TKNL ++ A++L+ AVG+ GFI + + + +I+IDVGIN L +GK Sbjct: 172 KGIDATVTICHSRTKNLVEKIKRANVLVSAVGRAGFITKEMVGKDSIIIDVGIN-LYDGK 230 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 +VGDV FE + ITPVPGGVG +T A L + + + Sbjct: 231 IVGDVDFEQVEPEVAAITPVPGGVGIVTTAILFRHFMVSSRR 272 >UniRef50_Q979W3 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Thermoplasma RepID=FOLD_THEVO Length = 281 Score = 272 bits (695), Expect = 1e-71, Method: Composition-based stats. Identities = 93/280 (33%), Positives = 163/280 (58%), Gaps = 8/280 (2%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 MA K++ G+ IA++ E+ ++++ +P L ++ VG+ A+ IY +K K ++ Sbjct: 1 MAVKLLKGEEIAEKKAEELKERIE----KMGVSPRLVLLQVGNYSAATIYARAKIKRGKK 56 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G E ++ EL+ I+ L+AD ++GI+V+ PLP ID +++ I KDV Sbjct: 57 IGADVVLEKY-EDLTKQELVRRIEELSADKDVNGIMVENPLPKTIDYYDIVKSIPYYKDV 115 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 D PYN G + L P T +V +L+ Y + A +I S +VGRP+SM +L Sbjct: 116 DALSPYNQGSIAINREFLVPATAMAVVDILKYYGYEKT--TATIINRSPVVGRPLSMMML 173 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T ++ H T ++R + + +++VAVG+PGF+ ++ E ++VIDVGIN +++ KV Sbjct: 174 NRDYTVSICHSKTPDIRSIAKASKIIVVAVGRPGFLDDTYVTESSVVIDVGINYVQD-KV 232 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 +GD+ F+ +++ +TPVPGGVGP+T ++ N ++A Sbjct: 233 IGDIDFDKVSEKVEAVTPVPGGVGPITATNILSNLVKAAE 272 >UniRef50_UPI00006CB712 tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain n=1 Tax=Tetrahymena thermophila RepID=UPI00006CB712 Length = 377 Score = 270 bits (692), Expect = 3e-71, Method: Composition-based stats. Identities = 100/280 (35%), Positives = 163/280 (58%), Gaps = 15/280 (5%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 +++G I++ V +V +++ + +R P LA++LVG+ S YV+ K++AC+ VG Sbjct: 30 LVNGNKISKDVLQKVKERI---LRVNIREPKLAIILVGNAADSISYVSVKQRACKRVGVQ 86 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S LPETT++ E++++++ LN +D IL QLP PA I V+ +I P KDVDG Sbjct: 87 SELIHLPETTTQKEVIQIVEDLNKREDVDSILTQLPFPAQISKTIVINQIEPSKDVDGLQ 146 Query: 125 PYNVGRLC---QRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 + + R PCTP+ + +L+ + ID G V++G +VG P+ LL Sbjct: 147 RCFLTQQLIWDDHNNRALPCTPQSCLHILDTHKIDVKGKQVVMLGKGLLVGSPLGAILLG 206 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL----EN 237 G ++ + + +L +++AD+L+ A G + G+ +K+G IVIDVG +R + Sbjct: 207 RGAIVSMCDKKS-DLSIALKDADILVSATGVRKLVKGEQLKKGVIVIDVGCSRPLPHEDQ 265 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 +VGDV FE AS +TPVPGGVGP+TV+ LI+N ++ Sbjct: 266 SSIVGDVEFES----ASLLTPVPGGVGPVTVSMLIQNVVK 301 >UniRef50_Q4A6B1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Mycoplasma synoviae 53 RepID=FOLD_MYCS5 Length = 278 Score = 270 bits (691), Expect = 3e-71, Method: Composition-based stats. Identities = 92/283 (32%), Positives = 148/283 (52%), Gaps = 12/283 (4%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 KI+ G+ A+Q ++ +++ R LA++ VG S YV K K +E+G Sbjct: 2 KILSGREKAEQDLKQLKKELDEL--NLNRPIKLAIIQVGDKMESNRYVEQKLKKAKEIGI 59 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 ++ + E ++ LL +D +N + DGIL+QLPLP + +L+ + +KD+DG Sbjct: 60 EAKCFKFDENITQKRLLLAMDEINEN--WDGILIQLPLPKHLPKEVILDAVPYEKDIDGL 117 Query: 124 HPYNVGRLCQ----RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 N L P R ++ L+E + I+ V+G S++VG+P++ L Sbjct: 118 SHRNEFILYNEKNSDDKFFVPAAARAVLELIEHHEINYKKKKVAVVGRSHLVGKPVAHIL 177 Query: 180 LLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN-- 237 G + + T V +AD++IVA+G P +I + IK+GAI+IDVG N +N Sbjct: 178 KRRGASVSTFDENTP--IKLVASADIVIVAIGVPKYIKAENIKQGAIIIDVGTNYDQNDP 235 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 + GDV E +AS ITPVPGGVGP+TV L++N ++ Sbjct: 236 SVIFGDVDHESVKTKASAITPVPGGVGPLTVVCLLKNLVEIYK 278 >UniRef50_B5RQK8 Methylenetetrahydrofolate dehydrogenase n=2 Tax=Borrelia RepID=B5RQK8_BORRA Length = 313 Score = 270 bits (691), Expect = 4e-71, Method: Composition-based stats. Identities = 104/282 (36%), Positives = 151/282 (53%), Gaps = 8/282 (2%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 + DGK A + + + + + L V+L ++PAS++YV+ K + +E+G Sbjct: 16 VFDGKIFANRYYLLLKEFL--IYHNLVSKISLKVILANNSPASELYVSVKERVSKEIGIN 73 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 L E + ++L LI+ N ++ DGI+VQLPL ID +L I KDVDG Sbjct: 74 FNVIRLSENLHQDDILRLIEIENTNDYTDGIIVQLPLANKIDVNMILNSILSIKDVDGLS 133 Query: 125 PYNVGRLCQRAP-RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA- 182 N+G+L PCT I+ +L Y I+ G VVIG S +VGR +S+ L Sbjct: 134 FVNLGKLVSGDKRGFIPCTALAILKILFDYKIEISGKTVVVIGRSLLVGRAISILLSCKP 193 Query: 183 -GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE---NG 238 T V H T NL +V+ AD++I AVGKP I I VID+GI+R++ + Sbjct: 194 YNATVIVCHSKTVNLDFYVKQADVIISAVGKPKLIDASMIVGHPYVIDIGISRVDVNNSS 253 Query: 239 KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 +VGDV FE R +ITPV GGVGP+TV L+ NT++A + Sbjct: 254 VLVGDVDFEAVKDRVRFITPVIGGVGPVTVLMLMFNTIKAYL 295 >UniRef50_Q4RT28 Chromosome 12 SCAF14999, whole genome shotgun sequence n=1 Tax=Tetraodon nigroviridis RepID=Q4RT28_TETNG Length = 342 Score = 269 bits (688), Expect = 8e-71, Method: Composition-based stats. Identities = 92/220 (41%), Positives = 126/220 (57%), Gaps = 10/220 (4%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A +I G+ +A+Q+R E V+ + G R P L+VVLVG +PAS YV +K +A ++ Sbjct: 29 EAVVISGRKLARQIREEARADVEKWVLTGHRRPHLSVVLVGDDPASHSYVLNKTRAAADI 88 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S + SE ELL+LID LN D+ +DG+LVQLPLP ID + + P KDVD Sbjct: 89 GISSETILKHSDISEEELLDLIDKLNTDHRVDGLLVQLPLPEHIDERTICNAVAPTKDVD 148 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GFH NVGR+C + P TP G+ +++R I T G N VV G S VG P++M L Sbjct: 149 GFHVVNVGRMCLDQSSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHT 208 Query: 182 AG--------CTTTVTHRFTK--NLRHHVENADLLIVAVG 211 G T T++HR+T L H + AD++I A G Sbjct: 209 DGRHERPGGDATVTISHRYTPKEQLCQHTKIADIVIAAAG 248 >UniRef50_D1VQM8 Methylenetetrahydrofolate dehydrogenase (NADP(+)) n=1 Tax=Frankia sp. EuI1c RepID=D1VQM8_9ACTO Length = 277 Score = 267 bits (683), Expect = 3e-70, Method: Composition-based stats. Identities = 104/280 (37%), Positives = 151/280 (53%), Gaps = 4/280 (1%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +++DG+ +A ++ V +V AG+ P LAVVL G + A+ + + VG Sbjct: 2 RLLDGRAMAAEIGRHVVDEVALLAEAGV-TPTLAVVLPGDDRAALSFARVIEQTAGRVGV 60 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + + L EL E + L AD + GIL Q PLPAG+ +V RI KDVDG Sbjct: 61 ACQRHQLSG--KPDELTETLGRLAADPAVHGILAQTPLPAGMTADEVGARIPASKDVDGM 118 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 +P ++GRL P P T +V +L R ++ G A VIG S +VG+P ++ LL Sbjct: 119 NPTSLGRLALGLPAFAPATAAAVVEILRRGDVPMAGARACVIGRSPVVGKPAALLLLAED 178 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T TV H T++L AD+++ AVG+P + +++ GA VIDVG N + G +VGD Sbjct: 179 ATVTVCHSRTRDLATVAHEADIVVAAVGRPKLVGAGFVRPGATVIDVGTNVTDEG-LVGD 237 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 V + A A +TPVPGGVGP+T L+ NT+QA Sbjct: 238 VDADAIAGVAGALTPVPGGVGPVTTMLLLRNTVQAAHRAR 277 >UniRef50_C4XED5 Putative uncharacterized protein n=1 Tax=Mycoplasma fermentans PG18 RepID=C4XED5_MYCFE Length = 298 Score = 266 bits (681), Expect = 5e-70, Method: Composition-based stats. Identities = 106/286 (37%), Positives = 158/286 (55%), Gaps = 10/286 (3%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 KI+DGKT+AQ+ E+ + + R P L+++ VG NPAS Y+ +K K EE+G Sbjct: 15 KILDGKTLAQKRTKELIAQFKDIKEKLGRKPILSIIQVGDNPASTHYIKNKLKKAEELGV 74 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + + P + +LL+ +D +N + DGI++QLPLP +L+ + +KD+DG Sbjct: 75 EAIHHHFPADIRQKDLLKKLDIINEKS--DGIVIQLPLPKEFATQVILDSVRIEKDIDGL 132 Query: 124 HPYNVGRLCQRAPRL--RPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 N +A P T GI+ LL YNI A VIG S++VG+P + L Sbjct: 133 CTRNAFNFYNQADDFTLVPATAIGILDLLNSYNIKMIDKKAAVIGRSSLVGKPTAFLLKQ 192 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE-NGK- 239 GC + +R T VENAD+++VA G+ + + IKEGA+V+DVG N +E +GK Sbjct: 193 EGCNVSTYNRNTG--IKGVENADIIVVAAGEAKLLKKENIKEGAVVVDVGSNWIEVDGKK 250 Query: 240 -VVGDVVFEDAAKRA-SYITPVPGGVGPMTVATLIENTLQACVEYH 283 + GDV E + S + PVPGGVGPMTV +L N ++ + H Sbjct: 251 ILHGDVDIETIPENYLSALAPVPGGVGPMTVISLFTNLAKSIIHIH 296 >UniRef50_Q4DH06 Methylenetetrahydrofolate dehydrogenase-like protein, putative n=1 Tax=Trypanosoma cruzi RepID=Q4DH06_TRYCR Length = 375 Score = 266 bits (681), Expect = 6e-70, Method: Composition-based stats. Identities = 102/330 (30%), Positives = 154/330 (46%), Gaps = 57/330 (17%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A+I+ G+ ++ + + +V + P LAVV+VG+ S+ YV+ K++ E Sbjct: 1 MKAEILLGRPLSGTLIERIQHEVARLSCS----PSLAVVMVGNRQDSRRYVSVKQRTAEA 56 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 G LPET SE L + + ++ DN DG+L+QLP+P+ + L IHP KDV Sbjct: 57 CGIRFHLLSLPETVSEERLHQELRRISDDNAFDGVLLQLPIPSHLRVRPALLCIHPGKDV 116 Query: 121 DGFHPYNVGRLCQRAP----------------------------RLRPCTPRGIVTLLER 152 DG HP N G L PCT + LL Sbjct: 117 DGLHPINAGSLFLDGNPIYEEAVHRGSSAEKEEALASRLLNEGRYFVPCTALAVHALLFS 176 Query: 153 YNID-----------TFGLNAVVIGASNIVGRPMSMELLL-AGCTTTVTHRFTKNL---R 197 Y + L+AV+I S +VG P + L T+ + +L + Sbjct: 177 YLANRTAVVPTPSKKPKNLHAVIINKSMVVGVPTAALLQKEDNFLVTLC-SRSNDLEAVK 235 Query: 198 HHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL---------ENGKVVGDVVFED 248 AD+L+ A+G P + D++K GAIV+DV IN + +V GDV Sbjct: 236 EVSRQADVLVTALGIPRVVTADFVKPGAIVLDVAINEDCASGGEMTSGSRRVCGDVDLAS 295 Query: 249 AAKRASYITPVPGGVGPMTVATLIENTLQA 278 ++A+ +TPVPGG+GP+TVA L++NTL+A Sbjct: 296 VREKAAAVTPVPGGIGPLTVAYLMQNTLKA 325 >UniRef50_Q8EV80 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Mycoplasma penetrans RepID=FOLD_MYCPE Length = 282 Score = 266 bits (680), Expect = 7e-70, Method: Composition-based stats. Identities = 98/288 (34%), Positives = 155/288 (53%), Gaps = 9/288 (3%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M ID IA + + ++ + P +A+V + + AS YV+ K K E Sbjct: 1 MIVNCID---IANNILDKFKSDLEKLKKKKI-IPHMAIVKINDDAASDKYVSIKLKKAAE 56 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G + ++ +L++ I LN D++IDG ++QLPLP G D+ + E I +KD+ Sbjct: 57 LGVKTTLIS-EGIKTQDDLIKQIHILNNDDSIDGYIIQLPLPKGFDSNVICEHIDVNKDI 115 Query: 121 DGFHPYNVGRLCQRAPRLRP--CTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSME 178 DG + + R + P CT GI+ +L++ N G +AV+I S IVG+P+ Sbjct: 116 DGLSSFAISRNLANSNLFHPKPCTANGIIEILKQSNYSIEGKHAVIINRSMIVGKPLIGL 175 Query: 179 LLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 L T TV H T+NL+ + AD+++VA+GKP F+ D + A VID GI+ + +G Sbjct: 176 FLENNATVTVCHTKTQNLKEMTKTADIVVVAIGKPDFLTKDMVNPNAFVIDAGISVV-DG 234 Query: 239 KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 KVVGD +D + YITPVP GVG +TVA + +N + E ++ + Sbjct: 235 KVVGDAA-KDLQEYVKYITPVPNGVGRLTVAMIFKNLMDLVKEKYNER 281 >UniRef50_B9KZ23 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=FOLD_THERP Length = 288 Score = 265 bits (678), Expect = 1e-69, Method: Composition-based stats. Identities = 100/268 (37%), Positives = 152/268 (56%), Gaps = 4/268 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 MAA I+ G+ + + + + + Q+V AR A P L V+L ++P++Q Y + RK Sbjct: 1 MAAHILSGRPVVESLHARI-QQVLARRAPHQGPPTLTVLLP-NDPSAQAYARAIRKQFTT 58 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 + R+ ++ +T E+ L+ L D ++ GIL PLP G+ + + P KDV Sbjct: 59 LSLNYRTEEIDDTLDESRFAILLKRLAEDESVTGILALQPLPKGVSRRSLARLMPPTKDV 118 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG GRL +P + P TP G + LL+ Y I+ G +AVVIG S +VGRP+++ LL Sbjct: 119 DGVSFEQQGRLAIGSPWIAPSTPLGGLILLQHYGIEVAGRHAVVIGRSPVVGRPLALLLL 178 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T T+ HR T +L ADLL VA G+P + D + GA+VID G++ + +G++ Sbjct: 179 ARDATVTICHRRTPDLAKLTRQADLLFVAAGQPHLVKPDMVAPGAVVIDFGVS-VRDGRL 237 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTV 268 +GDV A+ AS +TPVPGG GP+T Sbjct: 238 IGDVD-PAVAEVASALTPVPGGTGPVTT 264 >UniRef50_A7HMQ2 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Fervidobacterium nodosum Rt17-B1 RepID=FOLD_FERNB Length = 272 Score = 262 bits (670), Expect = 1e-68, Method: Composition-based stats. Identities = 89/270 (32%), Positives = 149/270 (55%), Gaps = 9/270 (3%) Query: 13 QQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPE 72 + + S + + ++ R++ + P L V + ++ Y+ S+ K + G Y+ P+ Sbjct: 6 EPLYSSMVENIKERVSKLSKPPKLVAVTCQPDSSTLAYLRSQEKQAKRFGIDFAVYEAPK 65 Query: 73 TTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLC 132 +L L+ L+AD +++GI + PLP+ I + + I PDKD++G HP N+G + Sbjct: 66 AM---DLKILLPKLSADGSVNGIFLTHPLPSDISEYEAVSLISPDKDIEGRHPINLGNIL 122 Query: 133 QRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG--CTTTVTH 190 P PCT ++ ++ Y + G VIG S VG+P++M LL G T T+ H Sbjct: 123 YDKPVFPPCTAEAVLRIIN-YLTNPSGKKIAVIGRSVTVGKPLAMLLLQKGIDATVTICH 181 Query: 191 RFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAA 250 TK++ +N+D+++VA+GK D+ K G IVIDVGIN +E ++VGDV + Sbjct: 182 SRTKDIAEITKNSDIVVVAIGKAKMFGKDYFKPGTIVIDVGIN-VEGDEIVGDVD-PSVS 239 Query: 251 KRASYITPVPGGVGPMTVATLIENTLQACV 280 + +TPVPGGVG +T L+E+T++A Sbjct: 240 EICE-LTPVPGGVGRITTLVLMEHTVKAAE 268 >UniRef50_B7J0W5 Methenyltetrahydrofolate cyclohydrolase n=22 Tax=Borrelia RepID=FOLD_BORBZ Length = 308 Score = 260 bits (666), Expect = 3e-68, Method: Composition-based stats. Identities = 96/281 (34%), Positives = 147/281 (52%), Gaps = 10/281 (3%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAP-GLAVVLVGSNPASQIYVASKRKACEEVGF 63 + +GK A + + + LR L VVL PAS +YV+ K + +E+G Sbjct: 11 VFNGKDFANKYYLMLK---EFLKQHNLRDKIALKVVLANDEPASNLYVSIKSRVAKEIGL 67 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + ++++LE+ID N + + DGI+VQLPL G+D +L I KDVDG Sbjct: 68 NVEVIKFSANSVQSDILEVIDRENKNLSTDGIIVQLPLLKGMDLNSILNSIVYSKDVDGL 127 Query: 124 HPYNVGRLCQR-APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 N+G++ PCT ++ +L I T G VV+G S +VGRP+S+ L Sbjct: 128 SFVNLGKMILGDKKGFIPCTALAVLKILRDEGIKTLGKTVVVVGRSPLVGRPISILLSSK 187 Query: 183 --GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE--NG 238 T H + L ++ AD++I AVGKP I + VID+GI+ +E NG Sbjct: 188 PYDATVIACHSKSIYLDVYLRQADIVISAVGKPRLIDKSMLCGKPYVIDIGISEIETDNG 247 Query: 239 KVV-GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 K++ GD F++ + +ITPV GG+GP+TV L+ NT++A Sbjct: 248 KILSGDTDFDNIKECVKFITPVKGGIGPVTVLMLMFNTIKA 288 >UniRef50_A6LP88 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Thermosipho melanesiensis BI429 RepID=FOLD_THEM4 Length = 271 Score = 259 bits (663), Expect = 6e-68, Method: Composition-based stats. Identities = 93/279 (33%), Positives = 158/279 (56%), Gaps = 14/279 (5%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 IID K + + ++ + ++++ R P L V +P++ Y+ S+ KA + G Sbjct: 2 IIDVKPLYEDIKVNLLKRIEKLK----RTPKLVAVTFKPDPSTVSYLKSQEKAAKRFGLD 57 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + E S +L+++ L+ DN ++GI V PL + ++ +++ E + P KD++G H Sbjct: 58 YEIF---EGNSPKGVLKILAELSRDNNVNGIFVTHPL-SQVNEMEIFENLVPSKDIEGRH 113 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG- 183 PYN+G L PCT +V ++E I G N V++G SN VG+P+++ LL Sbjct: 114 PYNLGMLAYGEEFFAPCTAEAVVRIMEN-EIGIPGKNVVIVGRSNTVGKPLAIMLLRRDR 172 Query: 184 -CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T TV H T+NL + AD+++ A G+PG I D +++ +I+IDVGIN + G ++G Sbjct: 173 SATVTVCHTKTRNLSSITKGADVVVAAAGRPGLITVDMVEKDSIIIDVGINVTDEG-IIG 231 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 DV +D A A +TPVPGGVG +T L+E+ +++ + Sbjct: 232 DVS-KDVANFAK-VTPVPGGVGKITTILLMEHLVKSAEK 268 >UniRef50_A5IXS7 FolD bifunctional protein(Methylenetetrahydrofolate Dehydrogenase; Methenyltetrahydrofolate cyclohydrolase) n=1 Tax=Mycoplasma agalactiae PG2 RepID=A5IXS7_MYCAP Length = 286 Score = 259 bits (662), Expect = 9e-68, Method: Composition-based stats. Identities = 98/281 (34%), Positives = 147/281 (52%), Gaps = 11/281 (3%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I++GK IA++ E+ ++ + R P L+++ VG NPAS +Y+ +K K EE+G Sbjct: 3 ILNGKIIAEERTVELKKEFEEITKLIGRQPVLSIIQVGDNPASSLYIKNKIKKAEELGVK 62 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF- 123 + Y E S+ LL+ +D LN ++ DGI+VQLPLP I ++ I +KDVDG Sbjct: 63 ATLYKFDEDISQNSLLKKLDVLNEES--DGIIVQLPLPEHISPKVIMNGIRLEKDVDGLC 120 Query: 124 --HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 +N P T I+ L+ Y ID G A VIG S +VG+P + L Sbjct: 121 EKSTFNFYNDKYDELSFTPATAAAIIDLINYYKIDLNGKKAAVIGRSYLVGKPTAFLLKK 180 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE-NGKV 240 G + ++ T + VE+ADLL+ A G+P + + IK+GA +ID G +E GK Sbjct: 181 LGAMVSTYNKNTG--INGVESADLLVSAAGQPDLVKKENIKDGAWLIDAGTTMIEREGKK 238 Query: 241 V--GDVVF-EDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 GD + + TP PGG+GP+TV L +N +A Sbjct: 239 CFVGDASLTPEEYQLLEGYTPTPGGIGPLTVIWLFKNLAKA 279 >UniRef50_Q1J118 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=Deinococcus RepID=FOLD1_DEIGD Length = 288 Score = 256 bits (655), Expect = 6e-67, Method: Composition-based stats. Identities = 97/292 (33%), Positives = 143/292 (48%), Gaps = 8/292 (2%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARI-AAGLRAPGLAVVLVGSNPASQIYVASKRKACE 59 M + GK +A V V ++ A P L VL + AS++YV SK + E Sbjct: 1 MTKAQLFGKPLADDVTRGVRAALKEWAGAEPGFQPHLVSVLASEDEASRVYVHSKARQAE 60 Query: 60 EVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKD 119 +G + DL + EL ++ L+AD + G++++LPL G+D L I P KD Sbjct: 61 RLGVRFTARDLGADAKQDELHAVLQALSADADVHGVVLELPLAPGLDADAALRHIAPCKD 120 Query: 120 VDGFHPYNVGRLCQR--APRLRPCTPRGIVTLLER-YNIDTFGLNAVVIGASNIVGRPMS 176 V+G P N+ + A L P TPR + LL D G VIG VGRP++ Sbjct: 121 VEGLTPANLALIAAGREAEALLPPTPRSVRFLLREVLGDDLRGRRVAVIGPGRTVGRPLT 180 Query: 177 MELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE 236 L G T T+ + T++LR + D ++VAVG G + + ++ +VID GIN + Sbjct: 181 FMLNNRGVTVTLCNECTRDLRDVLAPQDAVVVAVGHAGLLRPEQVQPHHVVIDAGIN-VT 239 Query: 237 NGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQDE 288 G VVGD V + TPVPGGVGP+T A + +N ++A + E Sbjct: 240 PGGVVGDAVPDLP---VRAQTPVPGGVGPLTSALMYQNLVRAVKLQRGERVE 288 >UniRef50_D1B5M7 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B5M7_THEAS Length = 292 Score = 256 bits (654), Expect = 8e-67, Method: Composition-based stats. Identities = 103/286 (36%), Positives = 147/286 (51%), Gaps = 11/286 (3%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 ++ G A V+ V ++V A LA V V S+ AS+ Y ++ +AC+E G + Sbjct: 3 LMRGSEPASWVKGWVRRQVSAL-----GGCCLASVSVSSHGASEAYRRNQIRACQEAGIL 57 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 R D+ + L+E I LN D +DGI+VQ PLP G D +VL+ + P KD +G H Sbjct: 58 VRPVDVAPSLGILGLIETIRELNGDREVDGIIVQTPLPEGWDLSEVLQAMDPAKDAEGVH 117 Query: 125 PYNVGRLCQRAPRL-RPCTPRGIVTLLERYNI-DTFGLNAVVIGASNIVGRPMSMELLLA 182 P N+G+L PC V LLE Y + D G+ V+G S VGRP+ LL Sbjct: 118 PENLGKLFLGVKGHPLPCAAWAAVGLLEWYGLWDLSGMVCAVVGHSVNVGRPIGALLLQR 177 Query: 183 GCTTTVTHRFTKN--LRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T H+ T L V ++ ++I A G PG I ++ GA V+DVG E G + Sbjct: 178 NGTVLQMHKHTPRDVLEELVSSSQVVISATGVPGLIGPGMVRPGAWVVDVGTTPTERG-L 236 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 VGDV A A ++PVPGGVGP+TVA L+ N + + + + Sbjct: 237 VGDVD-PQCASVAHGLSPVPGGVGPLTVALLMANLVLLASKRRNGR 281 >UniRef50_D1VRZ1 Bifunctional protein FolD n=1 Tax=Peptoniphilus lacrimalis 315-B RepID=D1VRZ1_9FIRM Length = 284 Score = 255 bits (651), Expect = 2e-66, Method: Composition-based stats. Identities = 81/255 (31%), Positives = 129/255 (50%), Gaps = 2/255 (0%) Query: 12 AQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLP 71 ++ +R + +K+ +I P LA++ +G P Y K +E+ Y L Sbjct: 18 SKDLRKRLKEKLLEKIENLNEKPVLAIIRLGQRPEDLSYEKGLTKTAKELSIPVDIYKLE 77 Query: 72 ETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRL 131 T +L+ LI+ LN D + GIL+ PLP ID +V I P KD+D +P N ++ Sbjct: 78 VQTKTIQLISLIEKLNEDKKVKGILIFRPLPKHIDEKEVALAISPQKDLDCINPINKAKI 137 Query: 132 CQRA-PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTH 190 P +P+ V L+E Y + A++I S +VG+P++M LL T T+ H Sbjct: 138 YDGDVNGFIPLSPKAAVMLMEDYGYNLA-KRALIINRSQVVGKPLAMLLLNRNATVTIAH 196 Query: 191 RFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAA 250 T+N++ ++ +D + A+GK + + E +I+ID+ I ENGK+ GD+ ED Sbjct: 197 SKTENIKELIKKSDYVFTAMGKMKSLDRSFFTEKSIIIDLSIGIDENGKLCGDIDQEDVN 256 Query: 251 KRASYITPVPGGVGP 265 TPVPGGVG Sbjct: 257 DFVQAYTPVPGGVGS 271 >UniRef50_A7AXK7 Putative uncharacterized protein n=1 Tax=Ruminococcus gnavus ATCC 29149 RepID=A7AXK7_RUMGN Length = 276 Score = 253 bits (646), Expect = 6e-66, Method: Composition-based stats. Identities = 91/253 (35%), Positives = 142/253 (56%), Gaps = 14/253 (5%) Query: 32 RAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNT 91 + P LAV+ + + AS Y+ K+K C+E+G R ++ T+E + +E + T A + Sbjct: 28 KKPVLAVIQIDDDQASNSYIKGKQKDCDEIGIEMRHVNIYSNTTEQKEVECVITDIAKSD 87 Query: 92 IDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLE 151 DGI++QLP+P + ++ I P+KDVDGF ++ +PCTP+GI+ +E Sbjct: 88 ADGIIIQLPIPDKYNLERLQHLIPPEKDVDGF---------RKDSCFKPCTPKGIIDWME 138 Query: 152 RYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVG 211 N + G + V+G S IVG P++ L+ G T T + T + ++ NAD AVG Sbjct: 139 YNNFEFEGKDCCVLGRSKIVGLPLTNMLIEKGATVTCCNSTTPSTWYYTRNADYAFSAVG 198 Query: 212 KPGFIP-GDWIKEGAIVIDVGINRLENGKVVGDVV---FEDAAKRASYITPVPGGVGPMT 267 P + D+ +V+D+GINR ENGK+ GDV FE + +Y+TPVPGGVG +T Sbjct: 199 VPNYFDFSDFQDFCELVVDIGINRDENGKLCGDVNNAGFESSLN-DTYVTPVPGGVGLLT 257 Query: 268 VATLIENTLQACV 280 TL++N + A Sbjct: 258 RLTLMQNVVDAYK 270 >UniRef50_UPI00003BDED9 hypothetical protein DEHA0E19294g n=2 Tax=Debaryomyces hansenii CBS767 RepID=UPI00003BDED9 Length = 276 Score = 252 bits (643), Expect = 2e-65, Method: Composition-based stats. Identities = 89/241 (36%), Positives = 130/241 (53%), Gaps = 16/241 (6%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLR--------------APGLAVVLVGSNPA 46 + A ++ G +A+ +RS++A+K+ P L ++ VG P Sbjct: 29 LDAAVVSGTLLAKSIRSKIAEKIVDYNTTNFSNLNASNINFDNLQFRPNLTIIQVGGRPD 88 Query: 47 SQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGID 106 S YV +K KA + +S E SE +LLE ID LN D ++G+L+QLPLP + Sbjct: 89 SSAYVKAKLKAAKSSNILSSLLKFDEDMSEEDLLEEIDRLNKDPKVNGLLIQLPLPKHFN 148 Query: 107 NVKVLERIHPDKDVDGFHPYNVGRLCQ--RAPRLRPCTPRGIVTLLERYNIDTFGLNAVV 164 + + +KDVDGF YNVG L + AP +PCTP GI+ L++ I G NAVV Sbjct: 149 ETLITNAVATEKDVDGFARYNVGELTKKGGAPMFKPCTPNGIMELIKTTGISLRGKNAVV 208 Query: 165 IGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEG 224 +G S+IVG P++ L CT T+ HR T +L V NAD+++ AVG P ++ DW+KE Sbjct: 209 LGRSDIVGTPVAAMLRNEDCTVTICHRHTYDLPSVVRNADIIVAAVGIPEYVKADWVKEN 268 Query: 225 A 225 Sbjct: 269 V 269 >UniRef50_D1J7X9 Methylenetetrahydrofolate dehydrogenase n=1 Tax=Mycoplasma hominis ATCC 23114 RepID=D1J7X9_MYCHP Length = 292 Score = 250 bits (639), Expect = 4e-65, Method: Composition-based stats. Identities = 96/279 (34%), Positives = 157/279 (56%), Gaps = 9/279 (3%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A +++GK I+ +V+ ++ + ++ P L ++ VG S IYV +K K ++ Sbjct: 1 MAILLNGKAISLKVKEDLKKAIEKMPQE--IRPTLGILQVGDLSESNIYVKNKLKYASDI 58 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAG--IDNVKVLERIHPDKD 119 G ++ L + S+ ++ E I+ LN +T G +VQ+P+ ID+ ++L+ I D D Sbjct: 59 GLNTKLIKLQQNASKLQIAEAIELLNKQST--GFIVQIPMQTNQIIDSQEILDLISIDHD 116 Query: 120 VDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 +DG +N+ L T GI LL +YNI VIG S IVG P++ L Sbjct: 117 IDGLTSFNLD-LKNPNNYFLSATASGIFLLLNKYNILYKNAKIGVIGQSKIVGYPLANFL 175 Query: 180 LLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGK 239 +L G ++ T ++++++ D++IVA G I D +K GA++IDVGI+R N K Sbjct: 176 VLKGYNVFRYNKDTP--KNNIKDLDIIIVATGTKDPITYDQVKPGAVIIDVGIHRDSNNK 233 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 + GD+ F + + AS+ITPVPGGVGPMT++ L+ N L+A Sbjct: 234 ISGDLNFNEFSNVASFITPVPGGVGPMTISALLINLLKA 272 >UniRef50_Q6KID0 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Mycoplasma mobile RepID=FOLD_MYCMO Length = 280 Score = 247 bits (630), Expect = 4e-64, Method: Composition-based stats. Identities = 100/281 (35%), Positives = 148/281 (52%), Gaps = 11/281 (3%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+DGK ++Q+ + +KV P +V VG+ +S Y+ +K E+G V Sbjct: 3 ILDGKKLSQKDTIFLKEKVNQFK----IKPVFTIVQVGNLFSSNKYIKTKMDKALEIGVV 58 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 SR +PE+ SE +L+ +I+ G++VQLPLP D K+L + KD+DG Sbjct: 59 SRLIKIPESISEKDLISIIEE--ESKISHGLIVQLPLPLQFDQSKILNSVPITKDIDGLS 116 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 N L ++P T RGI+ L++ YN VIG SN+VG+P+ AG Sbjct: 117 EKNSKNLYSGKSCIQPATARGIIDLIKEYNFTIKDKKVYVIGESNLVGKPIKELFKQAGA 176 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL-ENGKVV-- 241 + T E AD+LIVA G P + + +K +IVIDVGIN + EN K++ Sbjct: 177 IVKSFNINTG--IKGSEEADILIVAAGHPNLVKPENVKNNSIVIDVGINSIGENDKMIVT 234 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 GDV F + + I+PVPGGVGPMTV +L +N ++ +Y Sbjct: 235 GDVDFSNVKTKVKAISPVPGGVGPMTVISLFKNLIEIFEKY 275 >UniRef50_B3PMJ8 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Mycoplasma arthritidis 158L3-1 RepID=FOLD_MYCA5 Length = 293 Score = 246 bits (628), Expect = 7e-64, Method: Composition-based stats. Identities = 94/279 (33%), Positives = 157/279 (56%), Gaps = 11/279 (3%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+DGK +++ +++++A A A P L ++ VG+ S IYVA K K E +GF+ Sbjct: 4 ILDGKRLSEALQAKIAM---AFSAYRGPKPILGILQVGNKEDSNIYVAHKLKVAESLGFL 60 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGI--DNVKVLERIHPDKDVDG 122 ++ +PE +++ E++ + NA + GI+VQLPL + + ++L+ I +KD+DG Sbjct: 61 TKLVKMPENSTQDEIIGTLR--NAAAEVTGIIVQLPLVSNRIENLQEILDNIPIEKDIDG 118 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 YN+ TP+GI+ LL+ YNI+ ++G SNIVG+P++ L + Sbjct: 119 LSSYNLASNYNCKDNFLSATPKGIILLLKHYNINFRSTVIALVGQSNIVGKPLAKYL--S 176 Query: 183 GCTTTVTHRFTKNL-RHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 + K+ + + A ++IVA G + D + G ++IDVGI+R + + Sbjct: 177 NFKNNTIKTYVKDTPKDDLHEAKIVIVATGVYQSVTADQLANGTVLIDVGIHR-QGKTIH 235 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 GD+ F K+ASYITPVPGGVGP+TV L+ N ++A + Sbjct: 236 GDLDFASCFKKASYITPVPGGVGPLTVVALMFNLIKALI 274 >UniRef50_Q5IWX9 Plastid 5,10-methylene-tetrahydrofolate dehydrogenase (Fragment) n=1 Tax=Prototheca wickerhamii RepID=Q5IWX9_PROWI Length = 248 Score = 245 bits (625), Expect = 2e-63, Method: Composition-based stats. Identities = 90/189 (47%), Positives = 115/189 (60%), Gaps = 2/189 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A +IDGK IA+ +R E+ +V A PGLAVVLVG SQ YV SK+KAC+E Sbjct: 60 MPAALIDGKKIAETIRGELKVEVDELRAQYNTVPGLAVVLVGERKDSQTYVRSKKKACDE 119 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG S DLPET +E E+L ++ N D + GILVQLPLP I+ +VL+ I +KDV Sbjct: 120 VGINSFGADLPETATEEEVLAVVAKFNDDPNVHGILVQLPLPEHINEKRVLDAISLEKDV 179 Query: 121 DGFHPYNVGRLCQ--RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSME 178 DGFHP N+G L R+P CTP+G + LL+R + G A V+G SNIVG P ++ Sbjct: 180 DGFHPNNIGELAMRGRSPTYVSCTPKGCLELLKRAGVTLAGKRAAVVGRSNIVGLPAALL 239 Query: 179 LLLAGCTTT 187 L T T Sbjct: 240 LQQEDATVT 248 >UniRef50_B8ZZU9 Putative uncharacterized protein MTHFD2 n=2 Tax=Homininae RepID=B8ZZU9_HUMAN Length = 267 Score = 243 bits (621), Expect = 5e-63, Method: Composition-based stats. Identities = 94/290 (32%), Positives = 131/290 (45%), Gaps = 88/290 (30%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A +I G+ +AQQ++ EV Q+V+ +A+G + P L+V+LVG NPAS YV +K +A V Sbjct: 36 EAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVV 95 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 ID ++ + PDKDVD Sbjct: 96 -----------------------------------------EHIDERRICNAVSPDKDVD 114 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GFH NVGR+C + P TP G+ +++R I T G N VV G S VG P++M L Sbjct: 115 GFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHT 174 Query: 182 AGC--------TTTVTHRFTK--NLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVG 231 G T T++HR+T L+ H AD++I A G Sbjct: 175 DGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAG-------------------- 214 Query: 232 INRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 ++A YITPVPGGVGPMTVA L++NT+ A + Sbjct: 215 -----------------VRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKK 247 >UniRef50_A9BIV9 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=Thermotogaceae RepID=FOLD_PETMO Length = 273 Score = 239 bits (610), Expect = 1e-61, Method: Composition-based stats. Identities = 86/272 (31%), Positives = 143/272 (52%), Gaps = 12/272 (4%) Query: 13 QQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPE 72 + E+ ++ + P L ++V + +++ Y+ S+++ ++ G + Sbjct: 6 DNIIDEIKAEISSLKEKVPYEPKLVSLVVEPDESTKSYLNSQKRNAKKFGINLEIVE--- 62 Query: 73 TTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLC 132 +L + N D+ D I + PL G + + + I+P+KDV+G +N+G + Sbjct: 63 ---SNDLTNDLRKYNEDDDTDAIFIARPLKKGYTELDIAKYINPEKDVEGVSLHNIGSMF 119 Query: 133 QRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG--CTTTVTH 190 PCT +V ++E D G N V++G S VG+P ++ L G T TVTH Sbjct: 120 YEKELFVPCTAEAVVKIIEDT-TDVRGKNIVILGRSTTVGKPAAIMLQRHGRDATVTVTH 178 Query: 191 RFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAA 250 TKNL+ + AD+L+ A+GK F+ ++KEG IVIDVGIN + +GK+VGDV +D + Sbjct: 179 TKTKNLKEITKEADILVAAIGKANFVDSTFVKEGMIVIDVGINVV-DGKIVGDVN-KDVS 236 Query: 251 KRASYITPVPGGVGPMTVATLIENTLQACVEY 282 + +TPVPGGVG +T A L+ N +A Sbjct: 237 EICQ-LTPVPGGVGSVTTAILMRNVFRAANNK 267 >UniRef50_P47259 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Mycoplasma RepID=FOLD_MYCGE Length = 273 Score = 233 bits (594), Expect = 6e-60, Method: Composition-based stats. Identities = 82/269 (30%), Positives = 131/269 (48%), Gaps = 14/269 (5%) Query: 7 DGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSR 66 DGK AQ + L ++ + +S ++ K AC VG S Sbjct: 4 DGKLKAQSILE-------TYKNFDWSKCKLVIIQANDDDSSDSFIKQKLIACNTVGAKSE 56 Query: 67 SYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPY 126 L ++AEL+E I +LN D + GI++QLP+ +D +LE I+P KDVDG Sbjct: 57 LIKLSNQITQAELIEKIISLNHDVNVTGIILQLPVYPHLDKNSLLEAINPLKDVDGLTTN 116 Query: 127 NVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTT 186 ++ ++PC I+TL E +N++ VV+G G+P+ L +G Sbjct: 117 HLA-------EIKPCIVEAIITLKELFNLEFNNQKIVVVGLGITGGKPIYEFLKTSGYKV 169 Query: 187 TVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVF 246 + T N +++AD++ A+GK F K+G I+ D+G++R + K+ GD+ Sbjct: 170 QACDKDTPNTFELIKSADIVFTAIGKSHFFQAKNFKKGVILFDIGVSRNKQNKLCGDINP 229 Query: 247 EDAAKRASYITPVPGGVGPMTVATLIENT 275 E K+A + T PGGVGP TV +I+N Sbjct: 230 EGIEKKARWWTKTPGGVGPFTVLAIIKNL 258 >UniRef50_Q0AZF5 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Syntrophomonas wolfei subsp. wolfei str. Goettingen RepID=FOLD1_SYNWW Length = 277 Score = 232 bits (592), Expect = 1e-59, Method: Composition-based stats. Identities = 98/285 (34%), Positives = 146/285 (51%), Gaps = 14/285 (4%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +II G IAQ++R ++ +K +P LA++LVG YV K KA G Sbjct: 2 EIISGSQIAQEIRQKLKEK----NEREGISPCLAMILVGGQKEDLHYVGLKEKAATATGG 57 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNV--KVLERIHPDKDVD 121 SR LPE TS+ EL+ I LN D +DGIL+QLPLPA ++ ++L I PDKDVD Sbjct: 58 KSRLLHLPEDTSQQELMAKIAELNQDEQVDGILLQLPLPAALEEQTDEILAAIRPDKDVD 117 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GF N GR+ P C + ++ER+ G AV++G S + P++ ++ Sbjct: 118 GFSLVNRGRMSGDRPGFISCAALACLEVIERFFPSLAGKKAVLVGDSFDLIIPLATIMIK 177 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 C +V + L AD+L+V G+ G + + + G ++ID G G V Sbjct: 178 RACQLSVLPSYEPGLAS---GADILVVEKGRAGIVQAEGLAPGVLIIDAGF-YWGAGGVC 233 Query: 242 GDVVFEDAAKRASY---ITPVPGGVGPMTVATLIENTLQACVEYH 283 G+V A +R + + PVPGG+GP+ +A L+EN QA + Sbjct: 234 GNVD-RAALERQGFEARLLPVPGGMGPILIAKLMENLAQAARQKR 277 >UniRef50_A1RQQ5 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=Thermoproteaceae RepID=FOLD_PYRIL Length = 311 Score = 227 bits (580), Expect = 3e-58, Method: Composition-based stats. Identities = 100/291 (34%), Positives = 147/291 (50%), Gaps = 20/291 (6%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNP----ASQIYVASKRKACEEV 61 I G + + + V+ P LAV+L+ +P YV+ K + + + Sbjct: 5 IKGDRLHTETLEWARRHVKEL-ERYGVTPKLAVLLLNDDPIELETQHKYVSLKARDIKSI 63 Query: 62 GFVSRSYDL---PETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDK 118 G ++L P E L+LI+ LN + + GILVQ PLP +D K+ ER+ P K Sbjct: 64 GGEVELFELYKEPPEKREVAALKLIERLNNADDVTGILVQKPLPPYVDETKIFERLSPLK 123 Query: 119 DVDGFHPYNVGRLCQR---APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPM 175 DVDG P N RL + PCTP GI+ L +Y ID G + VV+G +VG P+ Sbjct: 124 DVDGLTPENKKRLVTGFDLDRDILPCTPAGILELFRQYKIDVRGKDVVVVGKGTLVGFPL 183 Query: 176 SMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGK--------PGFIPGDWIKE-GAI 226 S+ L+ T TV H +K+ +++V NAD++I AVG+ P + GD+IKE + Sbjct: 184 SIMLMQLDATVTVLHALSKDRKYYVRNADIIISAVGRPPELYSDNPWKLTGDFIKEGAVV 243 Query: 227 VIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 V G K DV + A++ASY+TP GGVG T A L++N + Sbjct: 244 VGVGGKVDPVTKKWYFDVDEKSVAEKASYLTPNIGGVGLATRARLVKNLII 294 >UniRef50_Q98QV3 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Mycoplasma pulmonis RepID=FOLD_MYCPU Length = 272 Score = 226 bits (576), Expect = 8e-58, Method: Composition-based stats. Identities = 85/282 (30%), Positives = 138/282 (48%), Gaps = 11/282 (3%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M K++ + Q R+E+ +K A+VL+G N +S+IYV K + ++ Sbjct: 1 MMKKLLS-NELVQIKRAELKEKFSKLDQKV----KFAIVLIGDNASSKIYVKKKIEFAQD 55 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G ++ + E L + + D DGI++QLP+ D ++L I +KD+ Sbjct: 56 IGVEAKLFHFEENVDFNLLKDAFKKI--DKEYDGIILQLPVL-HFDVNELLLMIDKNKDL 112 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG +P N + + P T R I T L+ + I V+G S +VG+P+S L Sbjct: 113 DGLNPENEKAFYENRECIIPATARAIWTFLKFHKISVENKKVFVVGQSRLVGKPISQFLK 172 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 V + T E AD+LIVA G I + IKE +I+IDVG +++ N K+ Sbjct: 173 NNNAIVRVFDKSTG--LKGTEEADILIVATGVAQLIKAENIKENSILIDVGFSKI-NNKI 229 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 GD+ E ++A TP G +GP+TV +L EN + ++ Sbjct: 230 YGDLDIESIKEKALKYTPPIGAIGPVTVLSLFENLYEIILKK 271 >UniRef50_UPI000194D930 PREDICTED: methylene tetrahydrofolate dehydrogenase 2 n=1 Tax=Taeniopygia guttata RepID=UPI000194D930 Length = 299 Score = 225 bits (574), Expect = 2e-57, Method: Composition-based stats. Identities = 101/260 (38%), Positives = 127/260 (48%), Gaps = 59/260 (22%) Query: 26 RIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDT 85 +AAG R P L+VVLVG NPAS YV +K KA +VG S + P + SE ELLELI Sbjct: 68 WVAAGNRRPHLSVVLVGENPASHSYVLNKTKAAADVGISSETILRPASISEEELLELIAK 127 Query: 86 LNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRG 145 LN+D +DG+LVQLPLP ID +V + P KDVDGFH NVGR+C + P TPRG Sbjct: 128 LNSDAAVDGLLVQLPLPEHIDERRVCNAVSPHKDVDGFHVLNVGRMCLDQDSMLPATPRG 187 Query: 146 IVTLLERYNIDTFGLNAVVIGASNIVGRPMSM---ELLLAGCTTTVTHRFTKNLRHHVEN 202 + +++R I S + RP S+ ELL Sbjct: 188 VWEIIQRTGIS-----------SETILRPASISEEELLELIAKLNSD-----------AA 225 Query: 203 ADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGG 262 D L+V + PG K+ASYITPVPGG Sbjct: 226 VDGLLVQLPLPG----------------------------------VRKKASYITPVPGG 251 Query: 263 VGPMTVATLIENTLQACVEY 282 VGPMTVA L++NT+ A + Sbjct: 252 VGPMTVAMLMKNTIIAAKKR 271 >UniRef50_UPI00016B2244 FolD bifunctional protein n=2 Tax=candidate division TM7 RepID=UPI00016B2244 Length = 338 Score = 223 bits (570), Expect = 4e-57, Method: Composition-based stats. Identities = 88/281 (31%), Positives = 136/281 (48%), Gaps = 17/281 (6%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGS-NPASQIYVASKRKACEEVG 62 KI++G +A V+ ++V+ + P L+VV V S N Y+ K+ ++ Sbjct: 67 KILNGAELASFVKVRQLKQVRNLRQSKKIIPKLSVVYVDSGNKVIDTYINLKKAYANDIL 126 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 Y T ++E ++ L+ D++I GI+VQLPLP +D ++L I+P+KDVDG Sbjct: 127 VEFSVYKENADT----IIERLNILSRDDSIHGIIVQLPLPGDLDTDQILSHINPNKDVDG 182 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 N P TP I LL Y ID G N ++G +VG P++ + Sbjct: 183 LSGGN----------FTPATPMAINWLLSGYGIDLSGKNVAIVGRGKLVGAPLTRLWKES 232 Query: 183 GCTTTVTHRFTK-NLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 G V + +L + D+++ A G G I +K GA+VID G E G + Sbjct: 233 GYNVDVFEKGDGYDLHIEIPKYDVIVTATGATGLIKSSMLKSGAVVIDAG-TASEKGIIK 291 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 GD+ + ++ ITP GGVGP+TVA L +NT+ A Sbjct: 292 GDLSDDVRERKDLIITPDKGGVGPLTVAALFDNTILAAYRQ 332 >UniRef50_A8IQS8 Methylenetetrahydrofolate dehydrogenase/ methylenetetrahydrofolate cyclohydrolase n=1 Tax=Chlamydomonas reinhardtii RepID=A8IQS8_CHLRE Length = 351 Score = 222 bits (567), Expect = 1e-56, Method: Composition-based stats. Identities = 93/283 (32%), Positives = 122/283 (43%), Gaps = 71/283 (25%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M +IDGK +A ++R E A K ++ + R PGLAVV+VG SQ YV K+K CE Sbjct: 25 MNGNVIDGKAVAAKIREETAAKSRSLKPSMARVPGLAVVIVGERKDSQTYVRMKKKVCE- 83 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VL I +KDV Sbjct: 84 ------------------------------------------------AVLGAISVEKDV 95 Query: 121 DGFHPYNVGRLCQR--APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSME 178 DGFHP N+GRL + P PCTP G + LLER I G AVV+G SNIVG P ++ Sbjct: 96 DGFHPLNIGRLAMKGREPLFTPCTPLGCMVLLERCGIPIKGKRAVVVGRSNIVGMPAALL 155 Query: 179 LLLAGCTTTVTHRFTK--NLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE 236 L TV H T + AD++I A G+ + G W+K GA VIDVG N ++ Sbjct: 156 LNKRDAAVTVVHSATPKADAEAMCRQADIIIAAAGQAQLVRGSWVKPGAAVIDVGTNPID 215 Query: 237 NGKVVGDVVFEDAAKRASYITP---VPGG-VGPMT--VATLIE 273 + +A + P V G VG + A L+ Sbjct: 216 D------------KTKAGAVIPGEHVAGRWVGSVQARAAVLLR 246 >UniRef50_C7GZF5 FolD protein n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7GZF5_9FIRM Length = 293 Score = 219 bits (558), Expect = 9e-56, Method: Composition-based stats. Identities = 82/294 (27%), Positives = 136/294 (46%), Gaps = 24/294 (8%) Query: 7 DGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSR 66 D K I++++ E+ V +A+V N A +Y + K E++ R Sbjct: 4 DCKQISEELLGEIKNDVAHL----GFNKEIAIVKSAKNSAGTVYENAIIKKAEKLNIPVR 59 Query: 67 SYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPY 126 S L E + + + L+ D I GI+ PL ID +V E I +KD+DG Sbjct: 60 SAVLEEGVDTEKAFKTVAKLSEDKDIAGIIPMQPLDESIDISRVKEAIACNKDIDGQTEK 119 Query: 127 NV-GRLCQRAPRLRPCTPRGIVTLLERY--NIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 ++ G R L P T + + ++ + L ++G S +VGRP+SM + Sbjct: 120 SMSGVFSFRKDALAPATALACIEIAKKVLGRENFKTLKVCILGRSLVVGRPLSMLFMKDD 179 Query: 184 CTTTVTHRFT--KNLRHHVENADLLIVAVGKPGFIPGDWI--------------KEGAIV 227 T TV H T N+ + +AD+++ AVG P F+ + + ++ + Sbjct: 180 ATVTVCHSKTGYDNIISSMADADIIVSAVGIPYFVTKEMVEGSFERRKELKSIDEDDRLF 239 Query: 228 IDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 IDVGIN ++GK+ GD+ E +Y+TPVP GVG +T + L +N L+ + Sbjct: 240 IDVGINF-KDGKITGDMESEAFKDEVAYVTPVPSGVGLVTTSVLFKNLLKGYRQ 292 >UniRef50_UPI0001B58450 methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase n=1 Tax=Streptomyces sp. SPB78 RepID=UPI0001B58450 Length = 357 Score = 211 bits (538), Expect = 2e-53, Method: Composition-based stats. Identities = 72/212 (33%), Positives = 107/212 (50%), Gaps = 1/212 (0%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A+ + GK +A +R V+A AG P LAVV + +S YV S A E+ G Sbjct: 12 ARPLRGKALAASLREGTRAAVEATRKAG-STPKLAVVTATDDESSAWYVRSLVSAAEKSG 70 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 + L S E+ + + L D ++ G+++Q PLP G+D + E + KDVDG Sbjct: 71 LLHEVVHLGPKASTEEVRDALRGLGEDGSVHGVILQTPLPPGVDARALAEAVPAAKDVDG 130 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 +P ++GRL P T ++ LL+ Y + G AVV+G S +VG+P++ LL Sbjct: 131 ANPLSLGRLAAGLAAFAPATAEAVIALLDHYEVPLRGARAVVVGRSTVVGKPLAHLLLAR 190 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPG 214 T TV H T++L AD+LI A G G Sbjct: 191 DATVTVCHSRTRDLAEVTREADILIAARGAAG 222 >UniRef50_B0RZW6 Methylenetetrahydrofolate dehydrogenase n=2 Tax=Finegoldia magna RepID=B0RZW6_FINM2 Length = 267 Score = 210 bits (536), Expect = 4e-53, Method: Composition-based stats. Identities = 74/273 (27%), Positives = 129/273 (47%), Gaps = 14/273 (5%) Query: 13 QQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPE 72 +++R ++ +++ + R +A V VG N Y + + C ++ L E Sbjct: 7 KELREDLGKRIIDGVEKLGREVKVATVRVGENAGDISYEKAVKNNCAKLNITCDQIVLEE 66 Query: 73 TTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGR-L 131 +E L++ I LN T DGIL+ PL ++ I P+KD+D N+G+ L Sbjct: 67 GENEK-LIQTIKELNE--THDGILMFRPLKDKNLEKEIQYIIAPEKDIDAMGMVNLGKVL 123 Query: 132 CQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHR 191 P T R +V +++ YN D N V++ S ++G+P+ L+ T T+ H Sbjct: 124 AAEEDAYYPATARAVVEIVKYYNFDV--KNVVIVNRSLVLGKPLFNMLIKENKTVTMCHS 181 Query: 192 FTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFE-DAA 250 T++++ +NADL++ AVGK + + + V+DVG++ ENGK+ GDV E D Sbjct: 182 RTEDIKSFTKNADLVVTAVGKAKMFDDSYFTKDSYVVDVGVSLDENGKLSGDVNPEVDVK 241 Query: 251 KRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 A VG +T L+ ++ + Sbjct: 242 VLA-------NSVGKITTRVLLLQMVEGALNRQ 267 >UniRef50_B3QMF3 Tetrahydrofolate dehydrogenase/cyclohydrolase n=2 Tax=Chlorobaculum RepID=B3QMF3_CHLP8 Length = 296 Score = 205 bits (522), Expect = 1e-51, Method: Composition-based stats. Identities = 79/317 (24%), Positives = 124/317 (39%), Gaps = 54/317 (17%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A +D IA R V +++ + + +L +PAS Y R CE+ Sbjct: 1 MKA--LDPSPIAAAFRDAVRREISDEKLSIN----IVGILASDDPASATYADYTRAGCED 54 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG TS + ++++ NAD+ + GI V P+ + ++ + I P KDV Sbjct: 55 VGISFDLRK----TSPESVRNMLESANADSDVHGIFVYYPIWGDSRDAELRDLISPHKDV 110 Query: 121 DGFHPYNVGRLCQRA---------PRLRPCTPRGIVTLLER------YNIDTFGLNAVVI 165 +G P+ + +L + PCTP I+ LLE Y + G + Sbjct: 111 EGLCPHWISKLYANERFDDEARKFKAILPCTPLAILKLLEETEAYIPYGLPFGGQQITIF 170 Query: 166 GASNIVGRPMSMELLLAGCTTTVT--------------HRFTKNLRHHV-ENADLLIVAV 210 S +VGRP++ L G H R +D++I V Sbjct: 171 NRSEVVGRPLAYMLSNDGARVYSFDIDGGFVVDVNDPGHERVPVTREEALRQSDIVITGV 230 Query: 211 GKPGF--IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTV 268 F I D +K GA+ ++ + ++N + DA + A P VGPMTV Sbjct: 231 PSKVFDKIKADELKSGAVCLN--FSSIQNFE-------PDAKESAGLYIP---RVGPMTV 278 Query: 269 ATLIENTLQACVEYHDP 285 A + N LQ YH Sbjct: 279 AMCMRNALQLYRNYHHE 295 >UniRef50_Q9XYB0 PugilistDominant (Fragment) n=2 Tax=Eukaryota RepID=Q9XYB0_DROME Length = 268 Score = 201 bits (513), Expect = 2e-50, Method: Composition-based stats. Identities = 69/176 (39%), Positives = 97/176 (55%), Gaps = 4/176 (2%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQAR-IAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 AKII G +A+ +R E+ +V A PGL +V VG S +Y+ K KA E+ Sbjct: 4 AKIISGTAVAKSIREELRNEVTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEI 63 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAG--IDNVKVLERIHPDKD 119 G + LP + +E ELL+ I+ LN D + GI+VQ+PL ID+ ++ + + P+KD Sbjct: 64 GIDAAHVQLPRSITEVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKD 123 Query: 120 VDGFHPYNVGRLCQRA-PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRP 174 VDG H N GRL PCTP G + L+ R ++ G AVV+G S IVG P Sbjct: 124 VDGLHTVNEGRLAIGDLGGFLPCTPWGCLELIRRSGVEIAGARAVVLGRSKIVGTP 179 >UniRef50_Q7NAE4 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Mycoplasma gallisepticum RepID=FOLD_MYCGA Length = 283 Score = 200 bits (508), Expect = 7e-50, Method: Composition-based stats. Identities = 72/279 (25%), Positives = 140/279 (50%), Gaps = 14/279 (5%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 +DG ++Q+++ ++A+KV + + +++ + AS+IYV +K C+ +G + Sbjct: 5 LDGTKLSQKLKEDLAKKV------NNQKIKILIIISDPSEASRIYVRNKINYCDSLGIQT 58 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 YDL + + + ++ + + +G+LVQLP+ +D K++E I DVD F Sbjct: 59 EVYDLSKIDDTNQFIVEMNQKISLSNPNGVLVQLPIKERLDTNKIIENIPIRLDVDAFLY 118 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCT 185 + + + ++ PC ++ L + Y + ++IG +P+ L Sbjct: 119 HRFDQ--DQKEKVIPCVLNAVLELFKEYQLSFLDKKILLIGNGITSNQPIVNYLNEHQIK 176 Query: 186 -TTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGK----- 239 +T ++ L + ADL+I AVGK F+ K G I ID+GI++ + + Sbjct: 177 FDLITKENSQLLEEKTKVADLVISAVGKAKFLANYQFKRGVIFIDIGIDKYFDPEQSKYL 236 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 + GD ++ + ASY TP PGG+GP+T+ +L++N + Sbjct: 237 ICGDFDYDKLKEIASYGTPTPGGIGPLTIYSLVKNLINL 275 >UniRef50_A9EVL6 Methylenetetrahydrofolate dehydrogenase (NAD(+)) n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9EVL6_SORC5 Length = 324 Score = 198 bits (505), Expect = 1e-49, Method: Composition-based stats. Identities = 74/318 (23%), Positives = 120/318 (37%), Gaps = 56/318 (17%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A ++D +A+ RSE+ ++ A + L VL + S Y RKACE+V Sbjct: 24 TASVLDPTAVAETFRSEIRAELAALPEPLV----LVGVLAADHGPSYTYAEYTRKACEDV 79 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + + E I N D + G++V P+ +V + + + P KD++ Sbjct: 80 GVRFEIRH----ATRLDAEEAIRAANEDARVHGMMVYYPIFGTEQDVYLRDSVDPAKDIE 135 Query: 122 GFHPYNVGRLCQRA---------PRLRPCTPRGIVTLLERYNI------DTFGLNAVVIG 166 G H + L Q + PCTP I+ L+E G + Sbjct: 136 GLHTFWARCLYQNQRFLDEAKTRKAILPCTPLAILKLVEAAGFFGEGERPLEGRRVCIFN 195 Query: 167 ASNIVGRPMSMELLLAGCTTTVTH-------------------RFTKNLRHHVENADLLI 207 S +VGRP++ + G T T + + AD+++ Sbjct: 196 RSEVVGRPLASMMAHDGAHVTSFDIDGPLLFVPSSSGDMHEVRETTVDRATALRQADIVV 255 Query: 208 VAVGKPGF--IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGP 265 V F + G I+EGA+ I+ + + +D +AS P VGP Sbjct: 256 TGVPSRSFPVVQGAEIREGALCINFSTFKNFS---------DDIQSKASVFVP---RVGP 303 Query: 266 MTVATLIENTLQACVEYH 283 MTV I N+L+ H Sbjct: 304 MTVTMAIRNSLRLYKNTH 321 >UniRef50_D1Z754 Whole genome shotgun sequence assembly, scaffold_7 n=2 Tax=Sordariaceae RepID=D1Z754_SORMA Length = 386 Score = 198 bits (503), Expect = 3e-49, Method: Composition-based stats. Identities = 78/329 (23%), Positives = 129/329 (39%), Gaps = 59/329 (17%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 K+I TIA+++ SEV + + P LA L +P++ Y +K CEE Sbjct: 53 TCKVILSDTIAKKLLSEVRETLAKIQGPDASKPTLAAFLATDDPSALQYAEWSKKTCEEN 112 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLP--AGIDNVKVLERIHPDKD 119 GF ++ +L E I N D+ +DGILV P+ + + E + KD Sbjct: 113 GFNFDLRK----VNKEDLEESIIAANNDDNVDGILVYYPIWVGNHSQDKYIKETVALSKD 168 Query: 120 VDGFHPYNVGRLCQR----------APRLRPCTPRGIVTLLER---------YNIDTFGL 160 V+G ++ + + PCTP IV LE Y FG Sbjct: 169 VEGLCHTHLFNMYHNVRFLDPPANLKKSILPCTPLAIVKTLEYLQIYNPILAYGNRLFGK 228 Query: 161 NAVVIGASNIVGRPMSMELLLAGCT-----TTVTHRFTKN-----------------LRH 198 VI S + GRP++ L G T T FT+ L+ Sbjct: 229 TITVINRSEVNGRPLAALLANDGATVYSVDVTGVQVFTRGEGIRQLRHQVHDKEGWELKD 288 Query: 199 HVENADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYIT 257 + +D++I V F +P + +++GA+ I+ + +G ++AS Sbjct: 289 VLPLSDVVIGGVPTEKFKVPTELLRDGAVCINFSSFKNFDG--------PAVKEKASIYV 340 Query: 258 PVPGGVGPMTVATLIENTLQACVEYHDPQ 286 P +G +T+A L+ N ++ P+ Sbjct: 341 P---SIGKVTIAVLLRNLVRLIANRPRPE 366 >UniRef50_Q02046 Methylenetetrahydrofolate dehydrogenase [NAD+] n=46 Tax=Ascomycota RepID=MTD1_YEAST Length = 320 Score = 196 bits (499), Expect = 8e-49, Method: Composition-based stats. Identities = 76/324 (23%), Positives = 133/324 (41%), Gaps = 60/324 (18%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQA-RIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 + I +A+ +E+ V+ + + P L L ++PA+++Y +K E + Sbjct: 5 GRTILASKVAETFNTEIINNVEEYKKTHNGQGPLLVGFLANNDPAAKMYATWTQKTSESM 64 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 GF YDL + L E I N D++++GI+V P+ + + + + +KDV+ Sbjct: 65 GFR---YDLRVIEDKDFLEEAIIQANGDDSVNGIMVYFPVFGNAQDQYLQQVVCKEKDVE 121 Query: 122 GFHPYNVGRLC---------QRAPRLRPCTPRGIVTLLERYNI---------DTFGLNAV 163 G + L R + PCTP IV +LE I +G + Sbjct: 122 GLNHVYYQNLYHNVRYLDKENRLKSILPCTPLAIVKILEFLKIYNNLLPEGNRLYGKKCI 181 Query: 164 VIGASNIVGRPMSMELLLAGCTTTVT-----HRFTKN--------------------LRH 198 VI S IVGRP++ L G T +FT+ L+ Sbjct: 182 VINRSEIVGRPLAALLANDGATVYSVDVNNIQKFTRGESLKLNKHHVEDLGEYSEDLLKK 241 Query: 199 HVENADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYIT 257 ++D++I V + P ++IKEGA+ I+ + + +D ++AS Sbjct: 242 CSLDSDVVITGVPSENYKFPTEYIKEGAVCINFACTKNFS---------DDVKEKASLYV 292 Query: 258 PVPGGVGPMTVATLIENTLQACVE 281 P+ G +T+A L+ N L+ Sbjct: 293 PMT---GKVTIAMLLRNMLRLVRN 313 >UniRef50_C7HUG7 Bifunctional protein FolD protein n=1 Tax=Anaerococcus vaginalis ATCC 51170 RepID=C7HUG7_9FIRM Length = 263 Score = 191 bits (485), Expect = 3e-47, Method: Composition-based stats. Identities = 63/251 (25%), Positives = 118/251 (47%), Gaps = 5/251 (1%) Query: 18 EVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEA 77 E+ + I + L ++ ++ A Y + + C E + + E Sbjct: 8 EIKNDILKNIKYCNKKKSLLIISQNNDLAVNQYKNAIIRRCNEFNIDYIDKEFSK---ED 64 Query: 78 ELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPR 137 L++I+ N IDG +V PL D + E I P D+DGF ++G++ + Sbjct: 65 NHLDIINYCNNLKNIDGFIVLQPLLESTDLDYLRENI-PFNDLDGFKYDSLGKIMSKKFE 123 Query: 138 LRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLR 197 P T + I+ + N+D G + ++ ++NI+G+P++M L + T+ + TKN + Sbjct: 124 NLPQTVKSIIKFINYMNLDLEGKDIIIANSTNIIGKPLAMYLNYKKASVTLFNSKTKNQK 183 Query: 198 HHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYIT 257 ++N D+ I A+GK + D+ + G I+ID G++ + +G + GD+ +E I Sbjct: 184 EKIKNCDIFISAIGKANYYNKDYFRNGQIIIDAGVSFV-DGNMYGDIDYEYIKDLDIKIV 242 Query: 258 PVPGGVGPMTV 268 GVG +T Sbjct: 243 TCKNGVGSITT 253 >UniRef50_B8BYF8 Predicted protein n=1 Tax=Thalassiosira pseudonana RepID=B8BYF8_THAPS Length = 370 Score = 190 bits (483), Expect = 5e-47, Method: Composition-based stats. Identities = 71/328 (21%), Positives = 120/328 (36%), Gaps = 56/328 (17%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 AK ID IA+ R E+ +V AG+ AP L +L ++PA++ Y KAC G Sbjct: 15 AKKIDAGDIAKPFREEIRNQVAKLKQAGIDAPLLVGLLANTDPAAKKYAEWTGKACRADG 74 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGI-------DNVKVLERIH 115 Y+L ++ + N D + GI+V P+ + + + + + Sbjct: 75 IR---YELRMIDDPIDVEAALCDANDDPRVHGIIVYYPIFGQVESFSGESQDDYLRDTVS 131 Query: 116 PDKDVDGFHPYNVGRLCQR---------APRLRPCTPRGIVTLLER----------YNID 156 DV+G L + + PCT +V +LE Sbjct: 132 HKCDVEGLCHQYRSNLYRNVRYMDRNHTKKCVLPCTALSVVKILESCESCYDKSKPIGRH 191 Query: 157 TFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNL--------------RHHVEN 202 G +I S IVGRP++ L G + L V Sbjct: 192 MEGQTVTIINRSEIVGRPLAAMLANDGADVYSIDIDSIYLFRGGKLHKCEGETPESCVRK 251 Query: 203 ADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASY-ITPVP 260 + ++I V + +P +WIK V++V + +V ++ + P+ Sbjct: 252 STVVITGVPTKNYRLPSEWIKPNTTVVNVASFK--------NVNEDEILQIEGVQYIPM- 302 Query: 261 GGVGPMTVATLIENTLQACVEYHDPQDE 288 VG +TVA L N ++ +H P + Sbjct: 303 --VGKVTVAMLERNLMRLFYNFHHPDRQ 328 >UniRef50_C4QVL0 NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase n=14 Tax=Saccharomyceta RepID=C4QVL0_PICPG Length = 389 Score = 189 bits (480), Expect = 1e-46, Method: Composition-based stats. Identities = 66/304 (21%), Positives = 121/304 (39%), Gaps = 58/304 (19%) Query: 8 GKTI-AQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSR 66 GKTI A + + ++++ + + P L +L +PA++ Y + CE +GF Sbjct: 81 GKTILASTIAKKYSEELTSVTSKMATKPKLVGLLGNQDPAAKTYAEWTARTCESLGFQYE 140 Query: 67 SYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPY 126 P+ E E I N D+ ++GI+V P+ + + + + +KDV+G + Sbjct: 141 LIQCPKENLEDE----IYKCNQDDAVNGIMVYFPVYNDGQDQYLQQCVSIEKDVEGLNFK 196 Query: 127 NVGRLCQR----------APRLRPCTPRGIVTLLER---------YNIDTFGLNAVVIGA 167 V + + PCTP +V +LE Y FG ++ Sbjct: 197 YVSNMYHNIRYLDAPENTKKSILPCTPLAMVKILEYLGVYNTLLPYGNRLFGKTITIVNR 256 Query: 168 SNIVGRPMSMELLLAGCTTTV-----THRFTKN----------------LRHHVENADLL 206 S IVGRP++ L G T +F + L+ +D++ Sbjct: 257 SEIVGRPLAALLANDGATVYSVDINNVQKFERGDGLQLKSHRVVDTEFELKDVAPKSDVI 316 Query: 207 IVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGP 265 I V + P +++K+GA+VI+ + + ++ AS P +G Sbjct: 317 ITGVPSSNYKFPLEYVKDGAVVINFSSEKNFDDRI---------KDIASLYVP---SIGK 364 Query: 266 MTVA 269 +T+A Sbjct: 365 VTIA 368 >UniRef50_B0CXH2 Predicted protein n=1 Tax=Laccaria bicolor S238N-H82 RepID=B0CXH2_LACBS Length = 308 Score = 187 bits (476), Expect = 4e-46, Method: Composition-based stats. Identities = 77/317 (24%), Positives = 121/317 (38%), Gaps = 63/317 (19%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 ++ I+ R EV + ++A + P L +L S+ S Y RK CEE+GF Sbjct: 9 LLKADPISAAFRDEVKKDLEACSSR----PKLVGILATSSAPSNNYAEFTRKQCEELGFE 64 Query: 65 SRSYDLPETTSE-----AELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKD 119 S + E I N D+++ GI+V P+ + + + + P KD Sbjct: 65 FVLKKTGAALSSDLAAGEGVEEAIIDANEDDSVHGIMVYYPIFGVQQDHYLQQVVSPLKD 124 Query: 120 VDGFH---PYNVGRLCQRAPR----LRPCTPRGIVTLLER---------YNIDTFGLNAV 163 V+G H YN+ + P + PCTP IV LE Y +G Sbjct: 125 VEGLHFKFHYNLYHKYEPPPGTVKSIIPCTPLAIVKCLEFVGVYNTILPYGDRAYGKTIT 184 Query: 164 VIGASNIVGRPMSMELLLAGCTTT-----------------------VTHRFTKNLRHHV 200 VI S +VGRP++ L G + H L + Sbjct: 185 VINRSEVVGRPLAALLANDGARVLSVDIDSIHVPYFSTLAQKYHPRHIVHPSNLTLEECL 244 Query: 201 ENADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFE-DAAKRASYITP 258 +D+++ AV P + + +K+G I ++V D FE D +AS P Sbjct: 245 AISDVVVSAVPSPSYKVKTALLKDGCICLNVAS----------DKNFEKDVRDKASLYIP 294 Query: 259 VPGGVGPMTVATLIENT 275 VG +T+ L+ N Sbjct: 295 ---AVGKVTILMLLRNL 308 >UniRef50_Q4PBA5 Putative uncharacterized protein n=3 Tax=Basidiomycota RepID=Q4PBA5_USTMA Length = 607 Score = 185 bits (471), Expect = 1e-45, Method: Composition-based stats. Identities = 88/392 (22%), Positives = 131/392 (33%), Gaps = 123/392 (31%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 K+I IA + + + +QARI G P L +L +P S Y RKACE VG Sbjct: 222 GKLIQASGIAAPYQDAIKEAIQARIQQGKSRPKLVGILATPSPPSVAYAEWTRKACEAVG 281 Query: 63 FVSRSYD----------------LPETTSEAELLELIDTLNADNTIDGILVQLPLPAGID 106 + P+ EA++ +LI NAD + GI+V P+ G Sbjct: 282 IEFEIWKTWDDSVEVKEEDHKGSAPDFDLEADVEDLIIAANADEKVHGIMVYYPIFFGRQ 341 Query: 107 NVKVLERIHPDKDVDGFH---------------PYNVGR-------LCQR---------- 134 + + + + P KDV+G H P +G L + Sbjct: 342 DTYLQQIVDPRKDVEGLHFSYCWNMYHNVRWISPAKLGNAPGTTRELPEERASREALDGE 401 Query: 135 ------APRLRPCTPRGIVTLLE---------RYNIDTFGLNAVVIGASNIVGRPMSMEL 179 A + PCTP +V LE Y +G VI S +VGRP++ L Sbjct: 402 QVPPGMAKSILPCTPLAMVKCLEAIGVYDRDLPYGDRLYGKTITVINRSEVVGRPLAALL 461 Query: 180 LLAGCTTTVT------------------------------------------HRFTKN-- 195 G H +N Sbjct: 462 SNDGAKVYSVDIDSIQEFNKRAVEPSSEPQGRARSEIVKEARAQNTASQLRPHHVVRNCS 521 Query: 196 --LRHHVENADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKR 252 + +D++I V + I +WIK GA+ ++ + D R Sbjct: 522 MTAEECIRASDVVIAGVPSANYKIETEWIKPGAVCVNFSSEKNFKS---------DVRTR 572 Query: 253 ASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 AS P +G T+A L N L+ VEY + Sbjct: 573 ASMYLP---AIGKTTIAMLQRNLLRL-VEYRE 600 >UniRef50_Q4S6Y9 Chromosome 14 SCAF14723, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4S6Y9_TETNG Length = 1066 Score = 183 bits (464), Expect = 8e-45, Method: Composition-based stats. Identities = 57/278 (20%), Positives = 108/278 (38%), Gaps = 22/278 (7%) Query: 13 QQVRSEVAQKVQARIAAG-LRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLP 71 ++V + + P LA++ G + + +K +G L Sbjct: 1 REVIEVTKEMITVLQRRNPAIRPSLAIIQAGEDDG---LLEINKKMARRIGLNVTQICLA 57 Query: 72 ETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRL 131 + SE E++ + L+ D + G+ + LP + +VL + P+KDVDG N G L Sbjct: 58 KECSEIEIVTEVLKLSEDPGVHGLYLHLPQAS--LTSRVLTALKPEKDVDGLSDLNTGCL 115 Query: 132 CQRA--PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVT 189 + P ++ L ++++ G +++G + + G V+ Sbjct: 116 IRGDLSAGFVPPVTSAVLEWLSKHHVTLEGKTVLILGGHGTFEVTLRCLIERQGIEVVVS 175 Query: 190 HRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDA 249 +KNL+ V AD ++V +P W K GA+V + E Sbjct: 176 DWTSKNLKSQVMRADAVVVLEAGKKNLPPTWFKPGALVFSCDPTSKTD---------ESV 226 Query: 250 AKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQD 287 A+ +S G+G +T A ++N Q+C + Q+ Sbjct: 227 AESSSN-----SGLGYLTAAYRMKNVAQSCGRWLQEQE 259 >UniRef50_C7RD94 Tetrahydrofolate dehydrogenase/cyclohydrolase n=3 Tax=Anaerococcus RepID=C7RD94_ANAPD Length = 260 Score = 179 bits (455), Expect = 9e-44, Method: Composition-based stats. Identities = 66/262 (25%), Positives = 121/262 (46%), Gaps = 10/262 (3%) Query: 17 SEVAQKVQARIAAGLRAPGLAVVLVGSNPASQI--YVASKRKACEEVGFVSRSYDLPETT 74 E+ + ++ + L +L+ NP S++ Y S K CEE + + Sbjct: 7 DEIKNSLIDKLGSHKFTNKL--LLLSKNPTSEVLYYKKSIIKRCEEFDIEYVDCEFDKE- 63 Query: 75 SEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQR 134 S E+L I+T + + DG ++ P G D + + I D+D F G + Sbjct: 64 SPEEILAFINTFDKE---DGYIILAPFGEGKDLTFLKDNIEIR-DLDAFTYKAQGHTMEG 119 Query: 135 APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTK 194 + P T R IV LE G + V+ + +G+P++M L+ T T+ R T Sbjct: 120 STERLPQTARAIVRFLEDKYSSLKGKHIVISNKTTTIGKPLAMNLVTKYATVTMITRHTA 179 Query: 195 NLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRAS 254 + ++ ++N+D+ I A+G+ F + ++G +V+DVG L +GK+VGD+ + Sbjct: 180 DQKNIIKNSDIFISAIGRANFYDRSYFRDGMLVVDVGTTYL-DGKIVGDIDYGSLEDVDI 238 Query: 255 YITPVPGGVGPMTVATLIENTL 276 + G+G +T L+E+ + Sbjct: 239 EVLTNKRGIGALTTLMLLESLI 260 >UniRef50_Q6UB35 Monofunctional C1-tetrahydrofolate synthase, mitochondrial n=54 Tax=cellular organisms RepID=C1TM_HUMAN Length = 978 Score = 177 bits (450), Expect = 3e-43, Method: Composition-based stats. Identities = 62/282 (21%), Positives = 114/282 (40%), Gaps = 18/282 (6%) Query: 11 IAQQVRSEVAQKVQARIAAG-LRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYD 69 I ++V + + P LA++ G + Q + EE G Sbjct: 74 IVREVIQNSKEVLSLLQEKNPAFKPVLAIIQAGDDNLMQ---EINQNLAEEAGLNITHIC 130 Query: 70 LPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVG 129 LP +SEAE+++ I +N D + G+ +Q + + + KVL + P+KDVDG N+G Sbjct: 131 LPPDSSEAEIIDEILKINEDTRVHGLALQ--ISENLFSNKVLNALKPEKDVDGVTDINLG 188 Query: 130 RLCQRA--PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTT 187 +L + + ++ LLE+ ++ G +V+GA + + G T Sbjct: 189 KLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTM 248 Query: 188 VTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD--VV 245 T+ L+ + AD++++ KP IP WI+ G V++ + L G + Sbjct: 249 SIQWKTRQLQSKLHEADIVVLGSPKPEEIPLTWIQPGTTVLNCSHDFLSGKVGCGSPRIH 308 Query: 246 FEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQD 287 F + I + A I+N + + + Q Sbjct: 309 FGGLIEEDDVIL--------LAAALRIQNMVSSGRRWLREQQ 342 >UniRef50_Q86KU6 Methylenetetrahydrofolate dehydrogenase [NAD+] n=1 Tax=Dictyostelium discoideum RepID=MTD1_DICDI Length = 313 Score = 176 bits (448), Expect = 6e-43, Method: Composition-based stats. Identities = 65/315 (20%), Positives = 113/315 (35%), Gaps = 60/315 (19%) Query: 7 DGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSR 66 D IA R EV Q++ P + L + + Y + AC++ G Sbjct: 16 DVTPIANFFREEVKQQI----TKNCWKPRVVAFLTSDDQGAIDYSKWTKLACQKDGIEFI 71 Query: 67 SYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPY 126 +L +LI N D+ + GILV P+ G+ + + + + P KD++G Sbjct: 72 LKR----VERVDLEDLIIEANNDSCVHGILVYYPVFGGMMDSYLQDVVSPTKDIEGLSTQ 127 Query: 127 NVGRLCQR----------APRLRPCTPRGIVTLLERYNI---------DTFGLNAVVIGA 167 N L + PCTP +V +++ I G ++ Sbjct: 128 NRFNLYHNIRFMDGETATKKCVIPCTPLAMVKIIDNLGIYDKSLAMGEHLKGKTVTIVNR 187 Query: 168 SNIVGRPMSMELLLAGCTTTVTH-------------------RFTKNLRHHVENADLLIV 208 S IVGRP++ L G + +D+LI+ Sbjct: 188 SEIVGRPLAAMLANDGAIVYSIDINGIIIFQSGKRHGTIKMSETNVTREEAISKSDILIL 247 Query: 209 AVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMT 267 V P + + D I++G IVI+ G + +++ + S + P +G +T Sbjct: 248 GVPSPNYKVNSDLIQDGTIVINFA----------GCLNVDESIQEKSILVPT---IGKVT 294 Query: 268 VATLIENTLQACVEY 282 +A L N L+ Sbjct: 295 IAMLERNLLRLFNNQ 309 >UniRef50_Q5KEZ0 Methylenetetrahydrofolate dehydrogenase (NAD+), putative n=2 Tax=Agaricomycotina RepID=Q5KEZ0_CRYNE Length = 367 Score = 173 bits (438), Expect = 8e-42, Method: Composition-based stats. Identities = 82/369 (22%), Positives = 123/369 (33%), Gaps = 105/369 (28%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 +I +A +SE+ + + + R P L +L ++ Y +KACE +G Sbjct: 6 LITASKVATPFKSELLSALASPRFSS-RPPHLVGILATKKEDARTYAEFTKKACETLGIT 64 Query: 65 SRSYDLPETTSEA--------ELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHP 116 L E E+ E I N D +DG++V P+ G + + + P Sbjct: 65 YEL-RLVGEAREGMDGEGVGIEVEEAILEANEDPEVDGMMVYYPIYGGRQDQYLQSVVSP 123 Query: 117 DKDVDGFHPYNVGRLCQRA---------------------------------------PR 137 KDV+G + + L Sbjct: 124 QKDVEGLNHQFLFNLYHNVRFINPLTLRPIPASHLPEPLPSKSGDSSKGEDVAPEGTVKS 183 Query: 138 LRPCTPRGIVTLLER---------YNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTV 188 + PCTP IV +LE Y G VI S +VGRP++ L G Sbjct: 184 ILPCTPLAIVKVLEHIGVYNRLLAYGDRARGKVITVINRSEVVGRPLAALLANDGARVIS 243 Query: 189 T---------------------------HRFTK----NLRHHVENADLLIVAVGKPGF-I 216 H T L + +D++I AV F + Sbjct: 244 VDLDSIVEFSKRPSKSAEGKKPSSASPHHITTPLPDMTLHKALSFSDVVISAVPVDSFKV 303 Query: 217 PGDWIKEGAIVIDVGINRLENGKVVGDVVFE-DAAKRASYITPVPGGVGPMTVATLIENT 275 P +K+G + ++V G+ FE D RAS P VG MT+ L N Sbjct: 304 PTRELKDGCVCVNVA----------GEKNFETDVRDRASIYVP---SVGVMTITMLQRNL 350 Query: 276 LQACVEYHD 284 L+ C EY D Sbjct: 351 LRLC-EYRD 358 >UniRef50_B1AIX6 Methylenetetrahydrofolate dehydrogenase n=15 Tax=Ureaplasma RepID=B1AIX6_UREP2 Length = 269 Score = 169 bits (430), Expect = 8e-41, Method: Composition-based stats. Identities = 55/243 (22%), Positives = 95/243 (39%), Gaps = 13/243 (5%) Query: 40 LVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAE--LLELIDTLNADNTIDGILV 97 LV N A Y+ SK K + YDL + L + N D + Sbjct: 35 LVNFNSA---YIQSKLKYAKLFSVKLIIYDLNAYQIQENHHFLSKLKQANKD----FLFF 87 Query: 98 QLPLPAGIDNVKVLERIHPDKDVDGFHPY-NVGRLCQRAPRLRPCTPRGIVTLLERYNID 156 + PL + + + D+DG + + + + + P T I+TL++ +++ Sbjct: 88 EFPLSKKHLDQNYFQYLTFQNDLDGINSHLFLNKKQENQIIYHPATINAILTLIKELDVN 147 Query: 157 TFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFI 216 +IG S +G + L + H TKN ++ ++ +I V K Sbjct: 148 LNDYRICIIGRSPYLGDYLYKLLNPKNNKINIIHSQTKNPLRIIKESNFIISCVNKAHIF 207 Query: 217 PGDWIKEGAIVIDVGINRLENGKVVGDV--VFEDAAKRASYITPVPGGVGPMTVATLIEN 274 + + + + +IDV + N K+ G DA R TPVPGG+G +T L N Sbjct: 208 NSNALSDNSYLIDVTTEYI-NNKLCGSFLINKNDALNRNIKYTPVPGGIGKLTTLFLFLN 266 Query: 275 TLQ 277 + Sbjct: 267 YFK 269 >UniRef50_B8NT34 Methylenetetrahydrofolate dehydrogenase, putative n=2 Tax=Aspergillus RepID=B8NT34_ASPFN Length = 307 Score = 169 bits (429), Expect = 8e-41, Method: Composition-based stats. Identities = 64/303 (21%), Positives = 113/303 (37%), Gaps = 58/303 (19%) Query: 21 QKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELL 80 ++ + + L VL + S Y RK C+E+G L S + Sbjct: 20 SQISEILTNTPKRLFLMGVLASDDAGSNQYANWTRKTCQEIGVHFHLMKL----SPKNVA 75 Query: 81 ELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAP---- 136 I +NA+N++ GI+V P+ + ++ + + P KDV+G + + R+ A Sbjct: 76 TYIRAINANNSVHGIIVYYPIFGDRRDDEIRQLVAPSKDVEGLNHQTLHRISDAAEVSRP 135 Query: 137 -----RLRPCTPRGIVTLLERYNI---------DTFGLNAVVIGASNIVGRPMSMELLLA 182 + PCTPR + +LE ++ +I S +VG P++ L Sbjct: 136 PKPGRNVIPCTPRAVAWILEWMDVHDRTRPAGERLQNQEICIINRSEVVGLPLAHLLAGE 195 Query: 183 GCTTTVTHR------------------FTKNL-----RHHVENADLLIVAVGKPGF-IPG 218 G K+L + V+ + ++I AV P F + Sbjct: 196 GARVYSVDISGVQLFQRLYYPWQSEALHGKDLPNWSVQDAVQRSRVVISAVPDPAFRVNT 255 Query: 219 DWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 W++ GAI ++V + VV + AS P VG +T+ L+ N + Sbjct: 256 KWLQRGAICVNVSSEKNFEANVV---------EVASKFVP---RVGSVTIGALLYNLILC 303 Query: 279 CVE 281 Sbjct: 304 SSR 306 >UniRef50_Q0UVW9 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum RepID=Q0UVW9_PHANO Length = 292 Score = 169 bits (428), Expect = 1e-40, Method: Composition-based stats. Identities = 64/306 (20%), Positives = 113/306 (36%), Gaps = 68/306 (22%) Query: 11 IAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDL 70 +A + + ++V+ ++ R P L L S+PA+++Y K C E GF ++ Sbjct: 12 LANNIAKSLLEEVRDGLSKIERKPLLVGFLSSSDPAARVYAEWTGKTCTENGFAFDLREV 71 Query: 71 PETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGR 130 E L++ N D+ I + DKDV+G + Sbjct: 72 DRELLEDALIDA----NNDDKI---------------------VSIDKDVEGLSHRYIFN 106 Query: 131 LCQR---------APRLRPCTPRGIVTLLER---------YNIDTFGLNAVVIGASNIVG 172 + Q + PCTP ++ +LE Y G VI S +VG Sbjct: 107 MYQNIRFLDPANTKKSILPCTPLAVIKILEYLRIYNTILPYGNRLHGRTITVINRSEVVG 166 Query: 173 RPMSMELLLAGCTTTV-----THRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIV 227 RP++ L G FT+ + +++ KPG+ D + +V Sbjct: 167 RPLAALLANDGACVYSVDISDVQEFTRGVGLRKRRHEVV----DKPGWTLDDCLPLSDVV 222 Query: 228 ID--------VGINRLENGKVVGDVVFE-----DAAKRASYITPVPGGVGPMTVATLIEN 274 I V + ++ +G V + E + ++AS P +G +T+A L+ N Sbjct: 223 ISGVPGDKYKVPLEKMRDGAVCINFSSERNFTPEVKEKASIYVP---AIGKVTIAVLLRN 279 Query: 275 TLQACV 280 L + Sbjct: 280 LLVSLQ 285 >UniRef50_A6QZK7 Putative uncharacterized protein n=1 Tax=Ajellomyces capsulatus NAm1 RepID=A6QZK7_AJECN Length = 297 Score = 165 bits (418), Expect = 2e-39, Method: Composition-based stats. Identities = 63/292 (21%), Positives = 106/292 (36%), Gaps = 56/292 (19%) Query: 11 IAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDL 70 +A V + +V AP L L S+PA+++Y K C++ F Sbjct: 17 LAANVARGLLAEVNEGRQTLSTAPHLVGFLANSDPAAKMYADWTEKTCKDNNFRYTL--- 73 Query: 71 PETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGR 130 T S ++ + I N+D +DGI+V P+ + + + + KDV+G + Sbjct: 74 -RTVSRDDIEDAILVANSDPDVDGIIVYYPIFNNRQDQYLQQIVDISKDVEGLSHRYIFN 132 Query: 131 LCQR----------APRLRPCTPRGIVTLLER---------YNIDTFGLNAVVIGASNIV 171 + Q + PCTP ++ +LE Y FG V+ S +V Sbjct: 133 MYQNIRFLDPPENKQKSILPCTPLAVIKILEYLQIYNTILPYGNRLFGHTICVVNRSEVV 192 Query: 172 GRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWI-KEGAIVIDV 230 GRP++ L G D+ G F G+ I K V+D+ Sbjct: 193 GRPLAALLANDGACVYSV--------------DV----TGVQQFTRGEGIRKRHHEVMDM 234 Query: 231 GINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 N + ++AS P +G +T+ L+ N L+ Sbjct: 235 EGNFGP-----------EVKEKASIYVP---AIGKVTIVVLLRNLLRIVQNR 272 >UniRef50_B5GAQ6 Tetrahydrofolate dehydrogenase/cyclohydrolase n=1 Tax=Streptomyces sp. SPB74 RepID=B5GAQ6_9ACTO Length = 333 Score = 160 bits (406), Expect = 4e-38, Method: Composition-based stats. Identities = 86/285 (30%), Positives = 127/285 (44%), Gaps = 32/285 (11%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLV----GSNP-------ASQIYVASK 54 + G + + VR +A A +G G+AVV +P AS++ K Sbjct: 7 LSGNALLRSVRENLAMYRDAIEPSGK---GIAVVRFTPTDSDSPEWVRRMEASRVSANQK 63 Query: 55 RKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERI 114 KA +GF LP T S AE + ID NAD+ I I+VQ P PA + +++R+ Sbjct: 64 VKAFSYLGFTVDHLVLPGTVSAAEFADRIDAFNADDHIRAIIVQFPPPARL--TPLVQRL 121 Query: 115 HPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDT-FGLNAVVIGASNIVGR 173 KD+DG L R+P T GI ++ I + V+GA VGR Sbjct: 122 EQIKDIDGL-------LEDRSPHRACATADGISRVV----IPVAEEASIAVVGARGFVGR 170 Query: 174 PMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGA-IVIDVGI 232 + L G V + +AD+++ GKP + D IK +V+D G Sbjct: 171 GVVRLLKDHG--LDVIPLDIGDDLRRAAHADIVVSTAGKPHILTPDHIKPHHRLVVDSGF 228 Query: 233 NRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 L +G V GD+ A ITPVPGGVGP+ +A L++ ++ Sbjct: 229 TPLPDGTVAGDI-HPAATYIPQNITPVPGGVGPIEMAVLMDRIIR 272 >UniRef50_UPI000023D48A hypothetical protein FG10624.1 n=1 Tax=Gibberella zeae PH-1 RepID=UPI000023D48A Length = 302 Score = 157 bits (397), Expect = 5e-37, Method: Composition-based stats. Identities = 64/286 (22%), Positives = 120/286 (41%), Gaps = 39/286 (13%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 +A+++ G + + + + + G P +AVV + + YV K Sbjct: 17 SARLLTGDLVVRDIE----RWCDRKADKGGVKPVMAVVYFNTGADAIDYVKIKAHVAARA 72 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G Y++P S +++ + LN + I GIL+Q PLP ++ +V+ I+P K+++ Sbjct: 73 GVSYWVYEMPVDASTTQVMTQVKKLNKNPRIHGILIQRPLPRQLNEPEVMRSINPIKNIE 132 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 + + +V LL +Y + A IVG Sbjct: 133 EYAKGRANNIAAD----------ALVRLLTKYGLRESAQQA----RIQIVG--------- 169 Query: 182 AGCTTTVTHRFTKNLRHHVENAD-------LLIVAVGK-PGFIPGDWIK-EGAIVIDVGI 232 +T F K ++ + ++I + + PGFI +K E ++++D+G Sbjct: 170 --FGNIITKEFIKQMKSQFPYMEVEAPRDSIIISELHRGPGFIKSSMVKSEVSVLVDLGF 227 Query: 233 NRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 E G V+GDV + + I P PGGV P+ + ++E T++A Sbjct: 228 YVTEKG-VLGDVSHVLFDRSSLAIAPTPGGVLPILLWIMMERTIKA 272 >UniRef50_B7G8Y9 Predicted protein (Fragment) n=8 Tax=Eukaryota RepID=B7G8Y9_PHATR Length = 274 Score = 155 bits (393), Expect = 1e-36, Method: Composition-based stats. Identities = 60/287 (20%), Positives = 100/287 (34%), Gaps = 54/287 (18%) Query: 34 PGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTID 93 P L +L +PA++ Y KAC G L + ++ + N D + Sbjct: 1 PLLVGLLANKDPAAKKYAEWTGKACRADGLRYELRVLDDPI---DVEAALMDANDDPRVH 57 Query: 94 GILVQLPLPAG-------IDNVKVLERIHPDKDVDGFHPYNVGRLCQR----------AP 136 GI+V P+ + + + + DV+G L + Sbjct: 58 GIIVYYPIFGQEESFSGASQDDYLRDSVSFKCDVEGLCHTYRTNLYRNVRYLDYPSNTEK 117 Query: 137 RLRPCTPRGIVTLLER----------YNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTT 186 L PCT +V +LE G VI S IVGRP++ L G Sbjct: 118 CLLPCTALSVVKILEECPGCYDMTRPLGKRNEGKTITVINRSEIVGRPLAAMLSNDGADV 177 Query: 187 TVT-------------HRFTKNLRHHVENADLLIVAVGKPGF-IPGDWIKEGAIVIDVGI 232 H+ + V + ++I V + +P +WI+E V++V Sbjct: 178 YSVDVNSIYLFTGGRLHKVDETPESCVRKSSVIITGVPTKSYRLPTEWIQEHTTVVNVSS 237 Query: 233 NRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 + + E+A + + VP VG +TVA L N ++ Sbjct: 238 FKNVD---------EEALLKIPGVVYVPL-VGKVTVAMLERNLMRLY 274 >UniRef50_B6WAQ3 Putative uncharacterized protein n=1 Tax=Anaerococcus hydrogenalis DSM 7454 RepID=B6WAQ3_9FIRM Length = 164 Score = 153 bits (386), Expect = 9e-36, Method: Composition-based stats. Identities = 47/158 (29%), Positives = 88/158 (55%), Gaps = 1/158 (0%) Query: 119 DVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSME 178 D+DGF ++G++ + + P T R I+ ++ +ID G + ++ ++N++G+P+SM Sbjct: 5 DLDGFRYDSLGKIMDKNFKNLPQTARSIIKFIDYMDIDLKGKDVIIANSTNVIGKPLSMY 64 Query: 179 LLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 L T T+ + T N + ++ AD+ I A+GK F D+ ++G ++ID G + + +G Sbjct: 65 LNYKKATVTLFNSKTINQKEKIKRADIFISAIGKANFYNVDYFRDGQVLIDAGTSFI-DG 123 Query: 239 KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 K+ GD+ ++ I GVG +T +LIE L Sbjct: 124 KMYGDIDYDSLENLKVDIVTCKNGVGSITTLSLIETLL 161 >UniRef50_D0NPK1 Methylenetetrahydrofolate dehydrogenase [NAD+], putative n=12 Tax=Phytophthora infestans T30-4 RepID=D0NPK1_PHYIN Length = 471 Score = 150 bits (380), Expect = 5e-35, Method: Composition-based stats. Identities = 70/335 (20%), Positives = 116/335 (34%), Gaps = 84/335 (25%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 ++ TIA+ V Q ++ G P L V KAC G Sbjct: 156 MNAATIAEPFSLAVRQYIE--QDMGGVGPKLVEVR-----------RGTGKACARDGIRY 202 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLP-------LPAGIDNVKVLERIHPDK 118 ++P+ ELLE ++ N D+ + GILV P G + + + I K Sbjct: 203 ELREVPKD----ELLEALEKANKDSDVHGILVYYPCFGAFPSFFGGTMDDFLRDSISIKK 258 Query: 119 DVDGFHPYNVGRLCQR---------APRLRPCTPRGIVTLLERYNI---------DTFGL 160 DV+G + G L + + PCT IV +LE + G+ Sbjct: 259 DVEGLCQFYRGNLYRNMRYVDDEKTQKCVLPCTHLAIVKILEHLGVYDKTKPTGDHLSGV 318 Query: 161 NAVVIGASNIV------------------GRPMSMELLLAGCTTTVTHRFTKNL------ 196 N V+ S+IV GRP++ L G ++ L Sbjct: 319 NITVVSRSDIVTANVPYSFTCRGRVSYIVGRPLAAMLANDGADVYSADIYSLYLFRRGKL 378 Query: 197 -------RHHVENADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFED 248 + + ++I V + +P +W+ E ++I+V + + E Sbjct: 379 IPSEETQETACKKSRVIITGVPVKSYKLPLEWVSENTVIINVASFKNVD-------EAEL 431 Query: 249 AAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 + P+ VG +TVA L N L+ +H Sbjct: 432 LKIKGVQYVPL---VGKVTVAMLERNLLRLYENFH 463 >UniRef50_A8ZN24 Putative uncharacterized protein n=1 Tax=Acaryochloris marina MBIC11017 RepID=A8ZN24_ACAM1 Length = 482 Score = 143 bits (361), Expect = 7e-33, Method: Composition-based stats. Identities = 60/239 (25%), Positives = 101/239 (42%), Gaps = 17/239 (7%) Query: 40 LVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQL 99 L+ A++ K K + +G +L +T+ E L+ +N + ++VQ Sbjct: 46 LLAKYEAARFSTEHKVKTFKALGCEVEHLNLDASTTSVEFGRLLKHVNKKSI--SVIVQN 103 Query: 100 PLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFG 159 P P D L I +KD+DG N T I ++E + + Sbjct: 104 PFPE--DFKSWLSEISYEKDIDGLRRDN-------PFFRVSATSETIFRIVEPFAQE--N 152 Query: 160 LNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGD 219 V+GA VG ++ L +G + + + A++++ A+G P + Sbjct: 153 DVVAVVGAEGFVGGGVTRLLEESGISVIGLDKN--DDLTLTRQANIVVSAMGSPNELDER 210 Query: 220 WI-KEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 I E +V+D G L + ++GDV A ITPVPGGVGP +ATL+E ++ Sbjct: 211 HIIPEHRLVVDSGFIPLADSPILGDVN-RSAYDIPLNITPVPGGVGPFQMATLMERLVR 268 >UniRef50_A6BAZ7 Fold bifunctional protein (Ppdc) (Fragment) n=1 Tax=Vibrio parahaemolyticus AQ3810 RepID=A6BAZ7_VIBPA Length = 183 Score = 141 bits (355), Expect = 4e-32, Method: Composition-based stats. Identities = 82/115 (71%), Positives = 94/115 (81%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A+ IDG I+Q VRSEVA +V+AR+AAGLRAPGLAVVLVG +PASQ+YV SKR+ACEE Sbjct: 1 MTAQNIDGTLISQTVRSEVAARVKARVAAGLRAPGLAVVLVGEDPASQVYVGSKRRACEE 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIH 115 VGFVS+S+DLP +TSE ELL LID LN DN IDGILVQLPLPAGID V + Sbjct: 61 VGFVSKSFDLPASTSEEELLALIDELNNDNEIDGILVQLPLPAGIDTTHVQSVFN 115 >UniRef50_Q5PNN5 Novel protein similar to methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofola (Mthfd1) (Fragment) n=3 Tax=Danio rerio RepID=Q5PNN5_DANRE Length = 263 Score = 136 bits (343), Expect = 8e-31, Method: Composition-based stats. Identities = 44/191 (23%), Positives = 73/191 (38%), Gaps = 10/191 (5%) Query: 11 IAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDL 70 I Q+ R E+ P LA++ G + + +K ++G L Sbjct: 81 IVQRCREELKS---IGENNPGLKPTLAIIQAGEDDG---LLEMNKKMAGKIGLNVMQICL 134 Query: 71 PETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGR 130 P +E E++E + LN D+ + GI + LP + V I P KDVDG NVGR Sbjct: 135 PHRCTEEEVIEEVLRLNKDSRVHGIFLHLP--QTFLSKSVRNAIKPQKDVDGVCDLNVGR 192 Query: 131 LCQRA--PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTV 188 + ++ LL +++ G AV++G + + L G Sbjct: 193 VVLGDKTDGFTSPVAGAVLELLAKHDAPLVGKMAVLVGLEGPLKVALQCLLQNNGMILQT 252 Query: 189 THRFTKNLRHH 199 + NL+ Sbjct: 253 CRWSSTNLQKQ 263 >UniRef50_UPI0000D9A063 PREDICTED: similar to Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor n=1 Tax=Macaca mulatta RepID=UPI0000D9A063 Length = 198 Score = 136 bits (342), Expect = 1e-30, Method: Composition-based stats. Identities = 51/155 (32%), Positives = 70/155 (45%), Gaps = 10/155 (6%) Query: 93 DGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLER 152 G LVQLPL D K+ PDK VD F NVG C + T + +++ Sbjct: 30 HGHLVQLPLAGHTDERKICNAFSPDKGVDDFPVMNVGLKCLDQYSMLLATRWDVRETIKQ 89 Query: 153 YNIDTFGLNAVVIGASNIVGRPMSMELLLAG--------CTTTVTHRFTKN--LRHHVEN 202 ++ VV G S IV P+ M L + G T ++ ++ N L+ H Sbjct: 90 TDVPILEKTVVVAGRSKIVRMPIVMSLHIDGAHERPRDDATVIISPGYSPNEQLKKHKIF 149 Query: 203 ADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 AD + A G P D IKE A VIDVGI R+++ Sbjct: 150 ADSVTSAAGIPSLFTIDIIKERAAVIDVGITRVQD 184 >UniRef50_B4FJK4 Putative uncharacterized protein n=1 Tax=Zea mays RepID=B4FJK4_MAIZE Length = 221 Score = 127 bits (321), Expect = 3e-28, Method: Composition-based stats. Identities = 47/102 (46%), Positives = 61/102 (59%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A IIDGK+IA+ +R +A++V + PGLAVVLVG S+ YV K K CEEV Sbjct: 94 TASIIDGKSIAEDMRLHIAEEVCQMKCSVGHVPGLAVVLVGDRRDSESYVRYKTKGCEEV 153 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPA 103 G S LP SE E+++ + N D ++ GILVQLPLP Sbjct: 154 GIKSLLAKLPGNCSEDEVMDSVSRFNEDPSVHGILVQLPLPE 195 >UniRef50_B5Y3N3 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B5Y3N3_PHATR Length = 365 Score = 127 bits (319), Expect = 5e-28, Method: Composition-based stats. Identities = 62/319 (19%), Positives = 115/319 (36%), Gaps = 60/319 (18%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNP---ASQIYVASKRKACEEV 61 ++D +AQ +R +V + LA VL + P S++Y + E Sbjct: 60 VVDVSDLAQSMREQVRAYTARVAPERV---HLAGVLARNGPHRSDSEVYAERIAETLESD 116 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G Y+ +++ ++I +N + + GILV P+ + + P KDV+ Sbjct: 117 GIDFTLYECIGE-KPSDVSKVIREMNGRSDVHGILVFYPIFKKNSPMYGRRKGPPLKDVE 175 Query: 122 GF-HPYNV-------GRLCQRAPRLRPCTPRGIVTLLERYNI-----------DTFGLNA 162 G H YN GR PCT ++ +L+ Y+ G Sbjct: 176 GLGHNYNARWIFRARGRNRMEREVYIPCTALAVMKILQTYHPLESSVAEAQHKRWAGFRV 235 Query: 163 VVIGASNIVGRPMSMELLLAGCTTTVTHRFTK---------------NLRHHVENADLLI 207 ++ S I+GRP++ L L G + + L + + +++ Sbjct: 236 TIVNRSEILGRPLAALLALEGASVYSVDDSSILEFMDGGRMRLRNDLTLNECLRQSAIVV 295 Query: 208 VAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITP----VPGG 262 V + +P D I V+++ + + + A TP +P Sbjct: 296 TGVPSEDYCLPCDMILPETTVVNIS-------------EYANVDEAAVIHTPHIRLIPQ- 341 Query: 263 VGPMTVATLIENTLQACVE 281 +G +TVA L +N + Sbjct: 342 IGKVTVAALEQNLILLHQR 360 >UniRef50_A4HZR2 Methylenetetrahydrofolate dehydrogenase-like protein n=3 Tax=Leishmania RepID=A4HZR2_LEIIN Length = 475 Score = 124 bits (311), Expect = 5e-27, Method: Composition-based stats. Identities = 48/134 (35%), Positives = 70/134 (52%), Gaps = 4/134 (2%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 +A+++ G I++ E+ Q+++ + R P L VVLVG + YV KR+A E Sbjct: 31 SAELLSGVPISK----ELRQRIRTSTSVLRRPPCLVVVLVGDRADAIRYVNHKRRAAAEC 86 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G L T + EL + ++N D +D +L+QLPLP + L IHP KDVD Sbjct: 87 GIEVHLVHLSATIQQVELHRTLASVNDDVEVDAVLLQLPLPPHLRTRPALLHIHPGKDVD 146 Query: 122 GFHPYNVGRLCQRA 135 G HP N G LC + Sbjct: 147 GLHPLNAGSLCLQD 160 Score = 118 bits (297), Expect = 2e-25, Method: Composition-based stats. Identities = 48/149 (32%), Positives = 68/149 (45%), Gaps = 20/149 (13%) Query: 156 DTFGLNAVVIGASNIVGRPMSMELLLAG-CTTTVTHRFTK--NLRHHVENADLLIVAVGK 212 L+AV++ S +VG P + L AG T+ R +RH + AD+LI A G Sbjct: 290 PRRDLHAVIVNNSRVVGVPTAALLQCAGSFAVTLCSRSNSLDTIRHVAQQADVLITAYGA 349 Query: 213 PGFIPGDWIKEGAIVIDVGINRLE-----------------NGKVVGDVVFEDAAKRASY 255 +++EGAIVID +N L + GDV + A+ Sbjct: 350 ANVFDRSFVREGAIVIDAAVNELPEMTCQKEAAAETGGSARKKGICGDVDINSVSAVAAA 409 Query: 256 ITPVPGGVGPMTVATLIENTLQACVEYHD 284 IT PGGVGP+T + L+ N L+A HD Sbjct: 410 ITKTPGGVGPLTASHLMFNVLKAYQLRHD 438 >UniRef50_B8BT80 Methylenetetrahydrofolate dehydrogenase (Fragment) n=1 Tax=Thalassiosira pseudonana CCMP1335 RepID=B8BT80_THAPS Length = 266 Score = 123 bits (310), Expect = 7e-27, Method: Composition-based stats. Identities = 52/271 (19%), Positives = 91/271 (33%), Gaps = 49/271 (18%) Query: 50 YVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNV- 108 Y +C G + + +P ++ L I N + G+LV P+ + + Sbjct: 3 YSEQILTSCTADGIIYEPWRVPP--TKDALERAIHHANERLDVHGVLVFYPIYDKLLDDV 60 Query: 109 -------KVLERIHPDKDVDGFHPYNVGRLCQRAPR---------LRPCTPRGIVTLLER 152 + + P KDV+G+ + + + PCT + +LE Sbjct: 61 YYKSMDCYFRDLVSPHKDVEGYCRKALRMKQPGSNEGGDHSLYGPIYPCTALAVYRILES 120 Query: 153 -YNID--TFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRF----------------T 193 + ID +I S ++G P++ L G T T Sbjct: 121 LHAIDRRFDKTTITIINRSEVLGIPLATMLSNQGATVYSVDINSILQFSPDGKIRREPST 180 Query: 194 KNLRHHVENADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKR 252 + V + ++ V F +P +WI + V++V + E Sbjct: 181 TTVETCVRQSSAVVSGVPSTEFLVPTEWISDNTTVVNVATES--------NFDEETIYNV 232 Query: 253 ASYITPVPGGVGPMTVATLIENTLQACVEYH 283 +T VP VG +TVA L N + YH Sbjct: 233 PG-VTYVPH-VGRVTVAALEYNLICLHRNYH 261 >UniRef50_C0Z3J6 AT2G38660 protein n=2 Tax=Arabidopsis thaliana RepID=C0Z3J6_ARATH Length = 185 Score = 119 bits (299), Expect = 1e-25, Method: Composition-based stats. Identities = 45/98 (45%), Positives = 63/98 (64%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 +IDG IA+++R+++ +V A + PGLAVVLVG SQ YV +K KACEE G Sbjct: 65 VIDGNVIAEEIRTKIISEVGKMKKAVGKVPGLAVVLVGEQRDSQTYVRNKIKACEETGIK 124 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLP 102 S +LPE +E +++ ++ N D +I GILVQLPLP Sbjct: 125 SVLAELPEDCTEGQIISVLRKFNEDTSIHGILVQLPLP 162 >UniRef50_Q3M1J6 Tetrahydrofolate dehydrogenase/cyclohydrolase n=3 Tax=Nostocaceae RepID=Q3M1J6_ANAVT Length = 396 Score = 119 bits (298), Expect = 2e-25, Method: Composition-based stats. Identities = 62/285 (21%), Positives = 107/285 (37%), Gaps = 30/285 (10%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAA-GLRAPGLAVVL--VGSN---------PASQIYVA 52 +IDG Q +R V Q+ Q + +A++ N A++I Sbjct: 3 LIDG----QLIREHVKQECQKYKSIFQASQKEVAIIRFEASENASNGLRARYEAARISAE 58 Query: 53 SKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLE 112 K +G L + + +I ++N ++ + +VQ P+PA + Sbjct: 59 QKVATFNAIGITPNYIVLSPNIAVEQFDNIIQSINENSKVTAAIVQYPIPAKFTTS--IG 116 Query: 113 RIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVG 172 + P KD+D + R T GI ++E Y + V G Sbjct: 117 LLEPQKDID------IVRRQSNNFFESCATAEGIARIVESYAQSDSNVAVVGGGGFVGN- 169 Query: 173 RPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGI 232 ++ L A + +L + AD+++ G+ G + +V+D G Sbjct: 170 --GVIKYLEASRISCFCLEDGDDL-SRTQAADIVVSVTGRQGIFTPYVLPSHRLVVDGGF 226 Query: 233 NRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 +G GDV A + ITPVPGGVGP+ +A L E ++ Sbjct: 227 TPTASGA-AGDVD-RSAYRIPQNITPVPGGVGPIEMAILAERLVK 269 >UniRef50_UPI00005A5066 PREDICTED: similar to Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor n=1 Tax=Canis lupus familiaris RepID=UPI00005A5066 Length = 239 Score = 117 bits (293), Expect = 6e-25, Method: Composition-based stats. Identities = 49/114 (42%), Positives = 70/114 (61%), Gaps = 11/114 (9%) Query: 175 MSMELLLAGCTTTVTHRFTK--NLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGI 232 ++ LL ++H++T L+ A+++I AVG I D IKEGA +I+VGI Sbjct: 88 LAQHLLQKD---PLSHQYTPKEQLKKCTVLAEIVISAVGILNLITADIIKEGAALINVGI 144 Query: 233 NRLEN-----GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 NR+++ K+VGDV FE K A+YITPV GVGPMTVA L++NT+ A + Sbjct: 145 NRVQDPILSKAKLVGDVDFEGIRKNANYITPV-WGVGPMTVAMLMKNTIIAAKK 197 >UniRef50_UPI0001904966 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Rhizobium etli RepID=UPI0001904966 Length = 175 Score = 115 bits (289), Expect = 2e-24, Method: Composition-based stats. Identities = 47/99 (47%), Positives = 59/99 (59%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 +IDGK +A V V A + GLAV++VG +PAS YV SK + +E GF Sbjct: 4 VIDGKNVAASVIQTVKSATAALEKSSGVTTGLAVIIVGDDPASHAYVGSKGRMAKECGFK 63 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPA 103 S + LP TS+AEL L+ TLNAD +I GILVQLPL Sbjct: 64 SVQHTLPAETSQAELAALVATLNADPSIHGILVQLPLAE 102 >UniRef50_B6FPJ6 Putative uncharacterized protein n=1 Tax=Clostridium nexile DSM 1787 RepID=B6FPJ6_9CLOT Length = 91 Score = 111 bits (278), Expect = 3e-23, Method: Composition-based stats. Identities = 36/82 (43%), Positives = 54/82 (65%) Query: 198 HHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYIT 257 V AD+++ A+G+ + +W+K+G +VIDV +NR +NGK+ GDV D ++ SYIT Sbjct: 4 EEVRQADIVVSAMGQAKLVKKEWLKQGTVVIDVEMNRDKNGKLCGDVELNDVMEKVSYIT 63 Query: 258 PVPGGVGPMTVATLIENTLQAC 279 PV G G +T A L+EN +QA Sbjct: 64 PVSKGDGFVTRAMLLENIMQAY 85 >UniRef50_B9PLA1 Methylenetetrahydrofolate dehydrogenase, putative n=3 Tax=Toxoplasma gondii RepID=B9PLA1_TOXGO Length = 630 Score = 109 bits (273), Expect = 1e-22, Method: Composition-based stats. Identities = 36/111 (32%), Positives = 60/111 (54%), Gaps = 3/111 (2%) Query: 128 VGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTT 187 GRL P PC ++ +L+ +++ G V+GAS VG+ +++ LL T Sbjct: 349 AGRLL---PFPAPCVALAVLDILKAWDMSLAGAAVAVVGASPRVGQAIALLLLQRQATVC 405 Query: 188 VTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 + H T++L+ + +D++I A G P I D ++ A VIDVG+N LE+ Sbjct: 406 LCHSRTRDLKGILLRSDVIIAAAGSPHLISSDMVRPNAAVIDVGVNVLESS 456 Score = 55.2 bits (132), Expect = 3e-06, Method: Composition-based stats. Identities = 18/39 (46%), Positives = 25/39 (64%), Gaps = 1/39 (2%) Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 VVGDV + ++ +ITPVP GVG +T A L+ L+A Sbjct: 572 VVGDVDLD-VNRKTKFITPVPQGVGLVTSAVLMRQVLKA 609 >UniRef50_A1ZUI3 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZUI3_9SPHI Length = 233 Score = 101 bits (251), Expect = 4e-20, Method: Composition-based stats. Identities = 61/212 (28%), Positives = 96/212 (45%), Gaps = 24/212 (11%) Query: 82 LIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPC 141 +ID+LN D I ++VQ P P G+ ++++++P KD+D R+ P Sbjct: 1 MIDSLNKDTNIGAVIVQSPPPKGL--ENIVKKLNPKKDLDALSGDKKNRMFP-----YPA 53 Query: 142 TPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLR---- 197 T GIV ++E + G VV+G +G + L G + + Sbjct: 54 TSEGIVRIVEPFA--EAGKKIVVVGGGGFIGEGVITMLKEKGIKPHIIDPRVIDDPGYQG 111 Query: 198 ---HHVENADLLIVAVGKPGFIPGDWIKEGAIVI-DVGINRLEN------GKVVGDVVFE 247 ++N D++I VGK G I G +K+ +I D G LEN V GDV Sbjct: 112 KDLALMKNYDIIISTVGKEGLIKGKDLKDDHTLIVDTGFVPLENVDKLTSKNVKGDVD-P 170 Query: 248 DAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 A + ++TPVPGG GP+ +A L+E + Sbjct: 171 TAKNKTKFVTPVPGGTGPVEMAVLMERVAKLF 202 >UniRef50_Q6X5D4 Methylene-THF dehydrogenase (Fragment) n=1 Tax=Treponema primitia RepID=Q6X5D4_9SPIO Length = 97 Score = 96.4 bits (239), Expect = 1e-18, Method: Composition-based stats. Identities = 31/98 (31%), Positives = 50/98 (51%), Gaps = 1/98 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A+++DGK +A + + + V+A A G+ P L ++ +G Y K EEV Sbjct: 1 MAQLLDGKVVAAALAESLKKDVEALKAKGV-TPTLGIIRLGEKGPDISYEKGATKRAEEV 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQL 99 G ++Y LPE T++ LL++I N D + G L Q Sbjct: 60 GAAVKNYILPEDTTQEALLKVIKEANDDKGVHGCLAQR 97 >UniRef50_D0NV87 Tetrahydrofolate dehydrogenase n=7 Tax=Phytophthora infestans T30-4 RepID=D0NV87_PHYIN Length = 261 Score = 67.9 bits (165), Expect = 3e-10, Method: Composition-based stats. Identities = 29/146 (19%), Positives = 54/146 (36%), Gaps = 24/146 (16%) Query: 152 RYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNL-------------RH 198 + +I+ + V + S IVGRP++ L G + L Sbjct: 123 KSDIEGSVHDIVSVHVSYIVGRPLAAMLANDGADVYSADIDSLYLFRRGKLIPSEETQET 182 Query: 199 HVENADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYIT 257 + + ++I V + +P +W+ E ++I V + + E + Sbjct: 183 ACKKSRVIITGVPVKSYKLPLEWVSENTVIIYVASFKNVD-------DAELLKIKGVQYV 235 Query: 258 PVPGGVGPMTVATLIENTLQACVEYH 283 P+ VG +TVA L N L+ +H Sbjct: 236 PL---VGKVTVAMLERNLLRLYENFH 258 >UniRef50_UPI00015563B5 PREDICTED: similar to Mthfd2-prov protein, partial n=1 Tax=Ornithorhynchus anatinus RepID=UPI00015563B5 Length = 161 Score = 67.9 bits (165), Expect = 3e-10, Method: Composition-based stats. Identities = 27/60 (45%), Positives = 41/60 (68%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A +I G+ +A+Q+R EV +V+ +A+G + P L+V+LVG NPAS YV +K KA +V Sbjct: 46 EAVVISGRKLARQIREEVRHEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTKAAADV 105 >UniRef50_D0NYB3 Tetrahydrofolate dehydrogenase n=1 Tax=Phytophthora infestans T30-4 RepID=D0NYB3_PHYIN Length = 402 Score = 67.1 bits (163), Expect = 6e-10, Method: Composition-based stats. Identities = 27/130 (20%), Positives = 48/130 (36%), Gaps = 24/130 (18%) Query: 168 SNIVGRPMSMELLLAGCTTTVTHRFTKNL-------------RHHVENADLLIVAVGKPG 214 S IVGRP++ L G + L + + ++I V Sbjct: 275 SYIVGRPLAAMLANDGADVYSADIDSLYLFRRGKLIPSEETQETACKKSRVIITGVPVKS 334 Query: 215 F-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIE 273 + +P +W+ E ++I+V + + E + P+ VG +TVA L Sbjct: 335 YKLPLEWVSENTVIINVASFKNVD-------EAELLKIKGVQYVPL---VGKVTVAMLER 384 Query: 274 NTLQACVEYH 283 N L+ +H Sbjct: 385 NLLRLYENFH 394 >UniRef50_B3L796 Putative uncharacterized protein n=2 Tax=Plasmodium (Plasmodium) RepID=B3L796_PLAKH Length = 614 Score = 52.9 bits (126), Expect = 1e-05, Method: Composition-based stats. Identities = 24/129 (18%), Positives = 47/129 (36%), Gaps = 9/129 (6%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARI------AAGLRAPGLAVVLVGSNPASQIYVASK 54 M + G +A Q+ V +K+ + + L ++ N A+ Y+ Sbjct: 1 MNCGTLYGYELASQIDQLVIRKIASGKIQIEGNRNWPQEKTLFIIY-SKNIATYSYLHIL 59 Query: 55 RKACEEVG--FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLE 112 K + + + +E L+ LI +N +++ PL I+ + Sbjct: 60 IKKSLLLNADVTFVMIRVHKGCNEKRLINLIKKINRRGKNTWLIILSPLSRHINKCYISS 119 Query: 113 RIHPDKDVD 121 I +KDVD Sbjct: 120 FISQEKDVD 128 Score = 50.9 bits (121), Expect = 5e-05, Method: Composition-based stats. Identities = 34/162 (20%), Positives = 53/162 (32%), Gaps = 63/162 (38%) Query: 140 PCTPRGIVTLLERYNIDTFGLNAVVIGA-----------------SNIVGRPM-SMELLL 181 PC I+ L+ Y I N +++ + S V P+ L Sbjct: 268 PCCVHAILLFLKYYQIHVKEKNVLILSSNISIFLSLFAFFFQSEVSTTVYDPLRGHVLCR 327 Query: 182 AGCTTTVTHRFTKNLRH------------------------------------------- 198 T + T NL Sbjct: 328 YDDKTKKCYLRTSNLGKLHIRDKADFKSKCKKFSKFYISTSKGYTKITHHDLSTLRKNMH 387 Query: 199 --HVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 V+N+DL+I+A+G P + +IKEGAI++D+GIN + G Sbjct: 388 TRIVKNSDLIIMAIGCPHILKKKYIKEGAIILDLGINLVPPG 429 Score = 50.6 bits (120), Expect = 6e-05, Method: Composition-based stats. Identities = 16/42 (38%), Positives = 27/42 (64%), Gaps = 1/42 (2%) Query: 234 RLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENT 275 L+N ++VGD E+ ++ + I+ VPGG+GP+T + L N Sbjct: 571 FLQNYEIVGDAD-ENCKQKCALISSVPGGLGPITTSMLFYNL 611 >UniRef50_C6KTE2 Putative uncharacterized protein n=1 Tax=Plasmodium falciparum 3D7 RepID=C6KTE2_PLAF7 Length = 657 Score = 51.7 bits (123), Expect = 3e-05, Method: Composition-based stats. Identities = 18/43 (41%), Positives = 27/43 (62%), Gaps = 1/43 (2%) Query: 233 NRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENT 275 N L+N ++GDV + + SYI+ VPGG+GP+T + L N Sbjct: 612 NILKNYVIMGDVDM-NCKNKCSYISSVPGGLGPITTSMLFYNL 653 Score = 50.6 bits (120), Expect = 6e-05, Method: Composition-based stats. Identities = 28/140 (20%), Positives = 60/140 (42%), Gaps = 10/140 (7%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGL------RAPGLAVVLVGSNPASQIYVASK 54 M I++G +++++ V +K++ A + R L ++ N S Y+ Sbjct: 1 MNGVILNGHYVSEKIDEFVLEKIKYEDAKNIHSKGWKRKKKLFIIY-SKNIVSYSYLYIL 59 Query: 55 RKACEEVG--FVSRSYDLPETTSEAELLELIDTLNADNTID-GILVQLPLPAGIDNVKVL 111 K + V + + SE +L+++I +N + D +++ PL I+ + Sbjct: 60 LKKSIYLNSDVVFVLIRVNKKVSEEKLIKIIKRININENNDTSLIILSPLSYHINKCYIS 119 Query: 112 ERIHPDKDVDGFHPYNVGRL 131 E I +KD+D + +L Sbjct: 120 EFIQKEKDIDCSNYKTFLKL 139 >UniRef50_D0YQ76 Bifunctional protein FolD 2 (Fragment) n=2 Tax=cellular organisms RepID=D0YQ76_9ACTO Length = 37 Score = 51.3 bits (122), Expect = 4e-05, Method: Composition-based stats. Identities = 15/31 (48%), Positives = 22/31 (70%) Query: 251 KRASYITPVPGGVGPMTVATLIENTLQACVE 281 + A+++TP PGGVGPMT A L+ N ++A Sbjct: 2 RVAAWLTPNPGGVGPMTRALLLVNVVEAAER 32 >UniRef50_Q0IEF9 Putative uncharacterized protein n=1 Tax=Aedes aegypti RepID=Q0IEF9_AEDAE Length = 51 Score = 48.3 bits (114), Expect = 3e-04, Method: Composition-based stats. Identities = 16/41 (39%), Positives = 26/41 (63%), Gaps = 1/41 (2%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGL-RAPGLAVVLV 41 AK+IDGK IA +R E+ ++++ + G RAP L +L+ Sbjct: 7 MAKLIDGKQIAADIRMELREQIEEWMKQGGNRAPHLTAILM 47 >UniRef50_C7YLA7 Predicted protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YLA7_NECH7 Length = 269 Score = 48.3 bits (114), Expect = 3e-04, Method: Composition-based stats. Identities = 22/97 (22%), Positives = 42/97 (43%), Gaps = 8/97 (8%) Query: 35 GLAVVLVGSNPASQIYVASKRKACEEVGFV--SRSYDLP---ETTSEAELLELIDTLNAD 89 L ++ + + + +V K+ +++G + LP E+T L + LN + Sbjct: 3 HLVLINLDPSRDTSPHVRFKKDKIQDLGLDLTCVVWTLPQSSESTPIETLRLKLRELNEN 62 Query: 90 NTIDGILVQLPLPAG---IDNVKVLERIHPDKDVDGF 123 + G+ PLP G ID ++ + KDV+G Sbjct: 63 PEVVGVCFISPLPKGLGRIDLGELCLLLDEKKDVEGL 99 >UniRef50_Q4YPQ5 Putative uncharacterized protein n=4 Tax=Plasmodium (Vinckeia) RepID=Q4YPQ5_PLABE Length = 666 Score = 47.9 bits (113), Expect = 4e-04, Method: Composition-based stats. Identities = 16/42 (38%), Positives = 26/42 (61%), Gaps = 1/42 (2%) Query: 234 RLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENT 275 +N ++ GDV + K +S+I+ VPGG+GP+T + L N Sbjct: 607 FFKNYEIFGDVDL-NCRKNSSHISAVPGGIGPITTSMLFYNL 647 Score = 40.2 bits (93), Expect = 0.077, Method: Composition-based stats. Identities = 25/124 (20%), Positives = 50/124 (40%), Gaps = 9/124 (7%) Query: 8 GKTIAQQVRSEVAQKVQARIAAGLR-------APGLAVVLVGSNPA-SQIYVASKRKACE 59 G I++++ + +K++ L L V+ + A S +Y+ K+ Sbjct: 4 GLPISEKIDQLILKKIENYKKENLENGIELEVKKNLYVIYSKNVVAYSYLYILLKKSIYL 63 Query: 60 EVGFVSRSYDLPETTSEAELLELIDTLNADN-TIDGILVQLPLPAGIDNVKVLERIHPDK 118 ++ + + S+ +L+ LI +N IL+ PL I+ V + I K Sbjct: 64 KLDINFILVKIDKKYSQEKLINLIKKINKKKGDNTSILILSPLSFHINKFYVSKFISEKK 123 Query: 119 DVDG 122 D+D Sbjct: 124 DIDA 127 >UniRef50_A4YD89 Glutamyl-tRNA reductase n=1 Tax=Metallosphaera sedula DSM 5348 RepID=HEM1_METS5 Length = 424 Score = 46.3 bits (109), Expect = 0.001, Method: Composition-based stats. Identities = 23/99 (23%), Positives = 38/99 (38%), Gaps = 20/99 (20%) Query: 156 DTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFT----KNLR------------HH 199 D G ++GA I G+ +++ L G T T +NL Sbjct: 178 DILGKKIAILGAGEIGGK-LALILHNEGATDVTIFNRTFERGRNLAIKYGYSYFPLDFSR 236 Query: 200 VENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 + N D++ A+ P + EG +VID+G + G Sbjct: 237 LHNYDIIFSAIFYPEKVKA---PEGTVVIDLGSPPVFEG 272 >UniRef50_A5MC89 Putative uncharacterized protein n=1 Tax=Streptococcus pneumoniae SP14-BS69 RepID=A5MC89_STRPN Length = 65 Score = 46.3 bits (109), Expect = 0.001, Method: Composition-based stats. Identities = 15/39 (38%), Positives = 24/39 (61%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVG 42 +IIDGK +A +++ ++A+K PGL V+LVG Sbjct: 3 QIIDGKALAAKLQGQLAEKTAKLKEETALVPGLVVILVG 41 >UniRef50_A4FH75 Ornithine/acetylornithine aminotransferase n=6 Tax=Bacteria RepID=A4FH75_SACEN Length = 824 Score = 45.2 bits (106), Expect = 0.003, Method: Composition-based stats. Identities = 21/110 (19%), Positives = 41/110 (37%), Gaps = 22/110 (20%) Query: 148 TLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTK------------- 194 T++ R + ++G +G M+ LL GC + HR + Sbjct: 141 TVIARLGRRPSDVEVGIVGFPGAIGLAMARLLLDDGCRLHLVHRKGRMRPEQLLDELPAA 200 Query: 195 ---------NLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL 235 ++ + L++ A G I D ++ G++V+DV + R Sbjct: 201 AHDRVTIGDDVAECLRRTRLIVAASSAGGLIDCDDLRPGSVVVDVALPRD 250 >UniRef50_C3YVA9 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae RepID=C3YVA9_BRAFL Length = 511 Score = 44.4 bits (104), Expect = 0.004, Method: Composition-based stats. Identities = 28/128 (21%), Positives = 47/128 (36%), Gaps = 21/128 (16%) Query: 133 QRAPRLRPCTPRGIVTLLERY-NIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHR 191 Q+ L C ++ L+R +I G + VV G VG+ L G VT Sbjct: 267 QKFDNLYSC-RESVLDALKRTTDIMFGGKHVVVCGYGE-VGKGCCSALRGLGAIVCVTEI 324 Query: 192 -------------FTKNLRHHVENADLLIVAVGKPGFIPGDWI---KEGAIVIDVGI--N 233 L + D++I A G + D + K G +V ++G Sbjct: 325 DPICALQASMEGFKVVTLNEVIRQVDVVITASGNKNVVTRDHLDRMKTGCVVCNMGHSNT 384 Query: 234 RLENGKVV 241 ++ G++V Sbjct: 385 EIDVGRLV 392 >UniRef50_C3Y6A1 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae RepID=C3Y6A1_BRAFL Length = 1329 Score = 44.0 bits (103), Expect = 0.005, Method: Composition-based stats. Identities = 23/87 (26%), Positives = 38/87 (43%), Gaps = 5/87 (5%) Query: 142 TPRGIVTL---LERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRH 198 T RG++T L + G AVV GAS+ +G ++ L AG + R L+ Sbjct: 1068 TQRGVLTCNKKLRAASGPLAGKVAVVTGASSGIGASTALYLARAGAQVVLVARRVDRLQQ 1127 Query: 199 HVE--NADLLIVAVGKPGFIPGDWIKE 223 + A+ + VGK + +K+ Sbjct: 1128 LQKDVEAEGGVAIVGKADVVNRKEVKD 1154 >UniRef50_C6P544 Biotin/acetyl-CoA-carboxylase ligase n=1 Tax=Sideroxydans lithotrophicus ES-1 RepID=C6P544_9PROT Length = 330 Score = 43.6 bits (102), Expect = 0.007, Method: Composition-based stats. Identities = 31/122 (25%), Positives = 41/122 (33%), Gaps = 19/122 (15%) Query: 162 AVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWI 221 A + G S VG M L G L + + A +LI A G D + Sbjct: 153 AALSGLSLAVGVAMMRALAELGVQGVGLKWPNDVLLNDGKLAGILIEAQG-------DML 205 Query: 222 KEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 A+VI VGIN + G + + AS PVP N + A Sbjct: 206 GPSAVVIGVGINLTVPEALRGRID-QQVTDLASLGAPVP-----------ERNLVLAVSL 253 Query: 282 YH 283 H Sbjct: 254 KH 255 >UniRef50_A8L9A5 S-adenosyl-L-homocysteine hydrolase n=1 Tax=Frankia sp. EAN1pec RepID=A8L9A5_FRASN Length = 377 Score = 43.6 bits (102), Expect = 0.007, Method: Composition-based stats. Identities = 21/104 (20%), Positives = 41/104 (39%), Gaps = 14/104 (13%) Query: 138 LRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHR------ 191 + P + L+ + FGLNA ++G VGR ++ L G + +V Sbjct: 168 IGPSVAFSVEKLVRAMGVPLFGLNAGILGYGR-VGRNLAYSLAGRGSSVSVYDSDPLRRI 226 Query: 192 -------FTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVI 228 + + V+ +D+++ A G + D+ + VI Sbjct: 227 SAAADGFQSVSRESVVQTSDIIVGATGNTSLVEMDFPQLKHRVI 270 >UniRef50_C1XXU4 Predicted dehydrogenase n=1 Tax=Meiothermus silvanus DSM 9946 RepID=C1XXU4_9DEIN Length = 574 Score = 43.2 bits (101), Expect = 0.010, Method: Composition-based stats. Identities = 38/151 (25%), Positives = 51/151 (33%), Gaps = 40/151 (26%) Query: 164 VIGASNIVGRPMSME----------LLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKP 213 ++G +VGR M L G T H T + ADL+ A P Sbjct: 411 LVGKLILVGRNMERLEKSAESLRKNLERKGQTP---HLVTTTDISAIREADLIFTATSDP 467 Query: 214 G-FIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGV----GPMT- 267 I + +K GA + D G+ DV ED K +PGGV G MT Sbjct: 468 KAVIRPEHVKPGAWIYDEGVPP--------DVD-EDVKKIPGVRV-IPGGVVRPPGNMTG 517 Query: 268 -----------VATLIENTLQACVEYHDPQD 287 A L E + A +D + Sbjct: 518 NLDLHFGQGAVPACLAETMILAAERAYDRKS 548 >UniRef50_B7PXT3 Putative uncharacterized protein n=1 Tax=Ixodes scapularis RepID=B7PXT3_IXOSC Length = 60 Score = 41.7 bits (97), Expect = 0.026, Method: Composition-based stats. Identities = 13/41 (31%), Positives = 22/41 (53%), Gaps = 1/41 (2%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLR-APGLAVVLV 41 A I+ G+ IA+++R ++A V+ A P L +V V Sbjct: 7 EAVILSGRQIAKEIREKLAVDVKEIKAKHPEFKPLLTIVQV 47 >UniRef50_B5Y9H6 Shikimate / quinate 5-dehydrogenase domain protein n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5Y9H6_COPPD Length = 352 Score = 41.7 bits (97), Expect = 0.026, Method: Composition-based stats. Identities = 40/170 (23%), Positives = 58/170 (34%), Gaps = 37/170 (21%) Query: 114 IHPDKDVD-GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVG 172 I K +D G N L + ID V+GA+ +G Sbjct: 111 ISIAKALDIGVTTGNSYTAYTAGEALLLAA--------KEVGIDPKSCTLTVVGATGSIG 162 Query: 173 RPMSMELLLAGCTTTVTHR------------------FTKNLRHHVENADLLIVAVGKPG 214 ++ L + R +T N+ V ADLLI P Sbjct: 163 SVLTKVLAPQVGRVILVARNMDRLQSLAEVLKNYDVDYTSNVSEGVRKADLLITVSSAPE 222 Query: 215 -FIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGV 263 I + ++ GAIV+DV +R N V E AK+ S + + GGV Sbjct: 223 AIIDAEDLQPGAIVVDV--SRPRN-------VAESVAKKRSDVLVLDGGV 263 >UniRef50_B0PHV3 Putative uncharacterized protein n=2 Tax=Bacteria RepID=B0PHV3_9FIRM Length = 295 Score = 40.9 bits (95), Expect = 0.049, Method: Composition-based stats. Identities = 37/166 (22%), Positives = 62/166 (37%), Gaps = 30/166 (18%) Query: 142 TPRGIVTL-LERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHR--------- 191 T G V + +E I FG +++G I R + L G + TV R Sbjct: 136 TAEGAVAIAMEELPIALFGSRCLIVGHGRI-ARALIRILRGMGASVTVAARSYGSLAEIE 194 Query: 192 -------FTKNLRHHVENADLLIVAVGKPGFIPG--DWIKEGAIVIDVGINRLENGKVVG 242 T L+ V+ AD++I V +K A+VID+ G Sbjct: 195 AEGCRAVRTDALKTSVKAADVVINTVPARMLTEPVLSALKHDALVIDLASRP-------G 247 Query: 243 DVVFEDAAK---RASYITPVPGGVGPMTVATLIENTLQACVEYHDP 285 V A + + + +PG P+T +I +T++ C+ + Sbjct: 248 GVDLAAAGRLGVKTIWALSLPGKTAPITAGEIILHTIENCLSELEE 293 >UniRef50_O29376 S-adenosylhomocysteinase hydrolase (AhcY-1) n=1 Tax=Archaeoglobus fulgidus RepID=O29376_ARCFU Length = 326 Score = 40.9 bits (95), Expect = 0.052, Method: Composition-based stats. Identities = 27/127 (21%), Positives = 54/127 (42%), Gaps = 15/127 (11%) Query: 142 TPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTV-THRFTKNLRHHV 200 T G++ L R N+ G A+++G VGR + L GC V + T+ + Sbjct: 135 TAFGLLDALLRLNVFLPGKKALILGFGR-VGRGCARLLKSVGCDVAVWDNDETRQIEALY 193 Query: 201 E--------NADLLIVAVGKPGFIPG---DWIKEGAIVIDVG--INRLENGKVVGDVVFE 247 E A++++ G G + + I +G+I++++G + G+++ D Sbjct: 194 EGFRVEKDFTAEVVVTCTGVKGVLGKEELEEISDGSIILNMGAEMEIEPAGELIKDYGLV 253 Query: 248 DAAKRAS 254 + A Sbjct: 254 KEYEIAG 260 >UniRef50_A0M2A6 Alanine dehydrogenase n=19 Tax=Bacteroidetes RepID=A0M2A6_GRAFK Length = 400 Score = 40.9 bits (95), Expect = 0.056, Method: Composition-based stats. Identities = 26/82 (31%), Positives = 40/82 (48%), Gaps = 10/82 (12%) Query: 159 GLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAV-GK---PG 214 G + V +S R + L T+T+ KNL ++ AD++I AV GK P Sbjct: 220 GASVKVFDSSLTKLRNIQANLGNTFYTSTI---QPKNLLKALKRADVVIGAVRGKDRSPI 276 Query: 215 FIPGDWI---KEGAIVIDVGIN 233 I + + K GA++IDV I+ Sbjct: 277 LITEEMVRTMKRGAVIIDVSID 298 >UniRef50_B4RWI6 S-adenosyl-L-homocysteine hydrolase n=3 Tax=Gammaproteobacteria RepID=B4RWI6_ALTMD Length = 372 Score = 40.5 bits (94), Expect = 0.062, Method: Composition-based stats. Identities = 27/156 (17%), Positives = 49/156 (31%), Gaps = 36/156 (23%) Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 +G H ++ L + ++ VVIG +VG+ ++ Sbjct: 166 EGLHNRHMVGLSAWQTFF------------QTTHLTLHEKLVVVIGYG-LVGQGVAASAK 212 Query: 181 LAGCTTTVTH-------------RFTKNLRHHVENADLLIVAVGKPGFIPGDWI---KEG 224 G V L AD++ A G G + + K+G Sbjct: 213 AFGAQVQVAELDPARALQAKYDGWPVVGLDEAASQADVIATATGAYGVVNSKHLDSMKDG 272 Query: 225 AIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVP 260 A +++VG V ++ AS+ P+P Sbjct: 273 AFILNVG-------HVAQEIDVPYLKNNASHSEPMP 301 >UniRef50_B1Z0C8 Short-chain dehydrogenase/reductase SDR n=4 Tax=Bacteria RepID=B1Z0C8_BURA4 Length = 266 Score = 40.5 bits (94), Expect = 0.064, Method: Composition-based stats. Identities = 19/90 (21%), Positives = 34/90 (37%), Gaps = 9/90 (10%) Query: 153 YNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGK 212 +++ G +V G++ +G ++ L G T V H + + V A + VA G Sbjct: 1 MDLNLRGKRVLVTGSTAGLGEAIAKLLAAEGATV-VVHGRSSDRAEAVAAA--ITVAGGH 57 Query: 213 PGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 + G + D G N + G Sbjct: 58 AE------VALGDLATDAGANAVVAKATEG 81 >UniRef50_C8W3U8 Shikimate/quinate 5-dehydrogenase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8W3U8_DESAS Length = 370 Score = 40.5 bits (94), Expect = 0.069, Method: Composition-based stats. Identities = 31/135 (22%), Positives = 45/135 (33%), Gaps = 28/135 (20%) Query: 153 YNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHV------------ 200 D + V+IGA+ +G+ + L T+ R T L Sbjct: 143 MGYDICQADIVIIGATGSIGKVCARYLAREVKNLTLVARDTSKLEEIAAKILFDYGLAVK 202 Query: 201 ---------ENADLLI---VAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFED 248 AD++I AV I +K GA+V DV R + KV + Sbjct: 203 VTPYSRSALRKADVIITVTSAVDT--IIGPGDLKPGAVVCDVSRPRNVSKKVAEERDDVL 260 Query: 249 AAKRASYITPVPGGV 263 + I VP GV Sbjct: 261 VIE--GGIVEVPHGV 273 >UniRef50_B8I2R3 Dipicolinate synthase subunit A n=5 Tax=Clostridium RepID=B8I2R3_CLOCE Length = 291 Score = 40.2 bits (93), Expect = 0.079, Method: Composition-based stats. Identities = 31/157 (19%), Positives = 58/157 (36%), Gaps = 32/157 (20%) Query: 142 TPRGIVTL-LERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLR--- 197 T G + + +E I N +++G I G+ ++ L G V R +L Sbjct: 134 TAEGAIQIAMEEMPITLHNSNTLILGYGRI-GKILAKMLHGIGSNVYVEARKYADLAWIK 192 Query: 198 -------------HHVENADLLIVAVGKPGFIPGDWIK---EGAIVIDVGINRLENGKVV 241 H ++ D++ + + + +K ++ID+ Sbjct: 193 SLGYSPVMLSDLSHILKKIDVIFNTIPSM-VLNYELLKLLNPECLIIDLASKP------- 244 Query: 242 GDVVFEDAAK---RASYITPVPGGVGPMTVATLIENT 275 G V F A +A + +PG V P+T A I++T Sbjct: 245 GGVDFNKAKDLGVKAIWALSLPGKVAPVTAAIFIKDT 281 >UniRef50_B1I1H2 Shikimate/quinate 5-dehydrogenase n=22 Tax=Clostridia RepID=B1I1H2_DESAP Length = 371 Score = 40.2 bits (93), Expect = 0.084, Method: Composition-based stats. Identities = 31/148 (20%), Positives = 50/148 (33%), Gaps = 29/148 (19%) Query: 141 CTP-RGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRF------- 192 T +G + V+GA+ +G + L T+ R Sbjct: 136 ATAIQGAREAARLMGHNLAEAEVAVVGAAGAIGSVCARILAREAKRMTLVGRNQQKLELV 195 Query: 193 --------------TKNLRHHVENADLLI---VAVGKPGFIPGDWIKEGAIVIDVGINRL 235 T +L + AD+++ AV I + +K GA+V DV R Sbjct: 196 ADSILADCGLAARITSDLAGALRRADVVVTVTSAVDT--IIEPEHLKPGAVVCDVARPRD 253 Query: 236 ENGKVVGDVVFEDAAKRASYITPVPGGV 263 + +VV V +D + VPG V Sbjct: 254 VSRRVVE--VRDDVLVIEGGVVEVPGPV 279 >UniRef50_Q4JAZ7 Adenosylhomocysteinase n=9 Tax=Archaea RepID=SAHH_SULAC Length = 415 Score = 39.8 bits (92), Expect = 0.099, Method: Composition-based stats. Identities = 25/101 (24%), Positives = 36/101 (35%), Gaps = 21/101 (20%) Query: 149 LLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRF---------------T 193 +L NI G AVVIG VGR ++ G V T Sbjct: 194 ILRATNILIAGKVAVVIGYG-WVGRGIASRFKGMGARVIVVESSPFRALEALMDGFDVMT 252 Query: 194 KNLRHHVENADLLIVAVGKPGFIPGDWI---KEGAIVIDVG 231 N + D+ + A G + D I K+GA++ + G Sbjct: 253 MNRASEI--GDIFVTATGNLNVVSRDHILRMKDGAVLANSG 291 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_A0LE04 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 400 e-110 UniRef50_Q0AB42 Methenyltetrahydrofolate cyclohydrolase n=19 Tax... 384 e-105 UniRef50_O65271 F6N23.26 protein n=34 Tax=Viridiplantae RepID=O6... 377 e-103 UniRef50_A7MT09 Methenyltetrahydrofolate cyclohydrolase n=64 Tax... 375 e-102 UniRef50_A3DEE6 Methenyltetrahydrofolate cyclohydrolase n=6 Tax=... 374 e-102 UniRef50_A5F6V4 Methenyltetrahydrofolate cyclohydrolase n=270 Ta... 373 e-102 UniRef50_Q82XC3 Methenyltetrahydrofolate cyclohydrolase n=7 Tax=... 371 e-101 UniRef50_Q2JQ25 Methenyltetrahydrofolate cyclohydrolase n=8 Tax=... 363 3e-99 UniRef50_B8HXS0 Methenyltetrahydrofolate cyclohydrolase n=25 Tax... 363 5e-99 UniRef50_B5YJV1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 361 2e-98 UniRef50_A8JH65 5,10-methylenetetrahydrofolate dehydrogenase n=4... 360 3e-98 UniRef50_C4FUB1 Putative uncharacterized protein n=1 Tax=Catonel... 356 5e-97 UniRef50_Q46A53 Methenyltetrahydrofolate cyclohydrolase n=13 Tax... 356 6e-97 UniRef50_Q8LEA3 5,10-methylenetetrahydrofolate dehydrogenase:5,1... 355 9e-97 UniRef50_Q6GI21 Methenyltetrahydrofolate cyclohydrolase n=83 Tax... 354 1e-96 UniRef50_D2QZP8 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 352 8e-96 UniRef50_B0KLM9 Methenyltetrahydrofolate cyclohydrolase n=184 Ta... 352 9e-96 UniRef50_A0K8R4 Methenyltetrahydrofolate cyclohydrolase n=254 Ta... 351 1e-95 UniRef50_A4XY05 Methenyltetrahydrofolate cyclohydrolase n=47 Tax... 351 2e-95 UniRef50_B2V9R3 Methenyltetrahydrofolate cyclohydrolase n=14 Tax... 349 6e-95 UniRef50_B0TFC9 Methenyltetrahydrofolate cyclohydrolase n=7 Tax=... 349 7e-95 UniRef50_P11586 Formyltetrahydrofolate synthetase n=378 Tax=root... 347 3e-94 UniRef50_Q12V26 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=... 346 4e-94 UniRef50_C2E8X3 Methylenetetrahydrofolate dehydrogenase (NADP+)/... 346 5e-94 UniRef50_Q049N0 Methenyltetrahydrofolate cyclohydrolase n=18 Tax... 346 8e-94 UniRef50_Q6F9E6 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 345 9e-94 UniRef50_B3ESU1 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 345 1e-93 UniRef50_Q9X7F6 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 344 2e-93 UniRef50_C7TD85 5,10-methylene-tetrahydrofolate dehydrogenase/me... 344 3e-93 UniRef50_UPI0001BC5140 bifunctional protein FolD n=3 Tax=Fusobac... 343 5e-93 UniRef50_Q17W13 Methenyltetrahydrofolate cyclohydrolase n=14 Tax... 341 2e-92 UniRef50_Q1II76 Methenyltetrahydrofolate cyclohydrolase n=15 Tax... 341 2e-92 UniRef50_A0M554 Methenyltetrahydrofolate cyclohydrolase n=88 Tax... 340 3e-92 UniRef50_Q11UD1 Methenyltetrahydrofolate cyclohydrolase n=6 Tax=... 340 4e-92 UniRef50_P13995 Methenyltetrahydrofolate cyclohydrolase n=52 Tax... 339 5e-92 UniRef50_C8PLX3 Bifunctional protein FolD n=1 Tax=Treponema vinc... 339 7e-92 UniRef50_Q8DMU0 Methenyltetrahydrofolate cyclohydrolase n=80 Tax... 339 8e-92 UniRef50_Q8RAD0 Methenyltetrahydrofolate cyclohydrolase n=11 Tax... 338 1e-91 UniRef50_B2S3X1 Methenyltetrahydrofolate cyclohydrolase n=35 Tax... 338 1e-91 UniRef50_C5BI30 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=... 338 2e-91 UniRef50_D0MY89 Bifunctional folD protein n=1 Tax=Phytophthora i... 337 2e-91 UniRef50_Q1QD30 Methenyltetrahydrofolate cyclohydrolase n=50 Tax... 336 4e-91 UniRef50_A5VAA8 Methenyltetrahydrofolate cyclohydrolase n=107 Ta... 336 5e-91 UniRef50_B8C1N0 5, 10-methylenetetrahydrofolate dehydrogenase n=... 336 5e-91 UniRef50_D0GMJ6 Bifunctional protein FolD n=2 Tax=Leptotrichia R... 336 7e-91 UniRef50_B1ZYH0 Methenyltetrahydrofolate cyclohydrolase n=8 Tax=... 334 2e-90 UniRef50_A5V1H2 Methenyltetrahydrofolate cyclohydrolase n=7 Tax=... 333 3e-90 UniRef50_UPI00015B59A5 PREDICTED: similar to ENSANGP00000016878 ... 333 4e-90 UniRef50_C8P9U1 Putative uncharacterized protein folD2 n=1 Tax=L... 332 1e-89 UniRef50_C1XHV3 5,10-methylenetetrahydrofolate dehydrogenase (NA... 330 3e-89 UniRef50_A9A4N5 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=... 330 3e-89 UniRef50_C8P269 Methylenetetrahydrofolate dehydrogenase/methenyl... 330 4e-89 UniRef50_B1GZ24 Bifunctional protein FolD n=2 Tax=Bacteria RepID... 329 5e-89 UniRef50_Q18GK1 Methenyltetrahydrofolate cyclohydrolase n=15 Tax... 329 6e-89 UniRef50_Q2GLF2 Methenyltetrahydrofolate cyclohydrolase n=41 Tax... 329 9e-89 UniRef50_D0J906 Putative methenyltetrahydrofolate cyclohydrolase... 327 2e-88 UniRef50_A9HEL1 Methenyltetrahydrofolate cyclohydrolase n=82 Tax... 327 4e-88 UniRef50_B0S8U6 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=... 326 8e-88 UniRef50_UPI0000DB7ABF PREDICTED: similar to Bifunctional methyl... 325 9e-88 UniRef50_D0N1V3 Bifunctional folD protein n=1 Tax=Phytophthora i... 325 1e-87 UniRef50_D1AX33 Methylenetetrahydrofolate dehydrogenase (NADP(+)... 325 1e-87 UniRef50_A8GNK0 Methenyltetrahydrofolate cyclohydrolase n=15 Tax... 325 1e-87 UniRef50_Q9H903 Methenyltetrahydrofolate cyclohydrolase n=75 Tax... 324 2e-87 UniRef50_A2BX55 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=... 324 2e-87 UniRef50_Q03RR1 Methenyltetrahydrofolate cyclohydrolase n=22 Tax... 324 2e-87 UniRef50_A8ZTQ4 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=... 324 2e-87 UniRef50_C3K8G7 Putative histidine biosynthesis-related tetrahyd... 324 2e-87 UniRef50_UPI00016C0DE6 Methenyltetrahydrofolate cyclohydrolase n... 323 4e-87 UniRef50_Q2SRE7 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=... 323 4e-87 UniRef50_Q4T2B9 Chromosome undetermined SCAF10300, whole genome ... 320 3e-86 UniRef50_C8PD95 Putative uncharacterized protein folD n=1 Tax=La... 319 5e-86 UniRef50_A6LU44 Methenyltetrahydrofolate cyclohydrolase n=22 Tax... 319 5e-86 UniRef50_C7N2I9 Methenyltetrahydrofolate cyclohydrolase /5,10-me... 319 6e-86 UniRef50_Q14NV1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 319 6e-86 UniRef50_C5R8B8 Bifunctional protein: methylenetetrahydrofolate ... 319 6e-86 UniRef50_C0GE27 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 319 8e-86 UniRef50_A8IFV5 5,10-methylenetetrahydrofolate dehydrogenase (Fr... 318 2e-85 UniRef50_C8W0Y6 Methylenetetrahydrofolate dehydrogenase (NADP(+)... 317 2e-85 UniRef50_C5C958 Methenyltetrahydrofolate cyclohydrolase n=118 Ta... 317 4e-85 UniRef50_A5N5B5 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=... 317 4e-85 UniRef50_D1CB15 Methylenetetrahydrofolate dehydrogenase (NADP(+)... 316 4e-85 UniRef50_Q189R8 Methenyltetrahydrofolate cyclohydrolase n=26 Tax... 316 8e-85 UniRef50_C0R292 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=... 316 8e-85 UniRef50_C9LM47 Methylenetetrahydrofolate dehydrogenase/methenyl... 314 2e-84 UniRef50_A8SN78 Putative uncharacterized protein n=1 Tax=Parvimo... 313 5e-84 UniRef50_D0N1T3 Bifunctional folD protein n=1 Tax=Phytophthora i... 313 5e-84 UniRef50_C6LCK2 Methylenetetrahydrofolate dehydrogenase/methenyl... 312 7e-84 UniRef50_Q254F7 Methenyltetrahydrofolate cyclohydrolase n=13 Tax... 312 8e-84 UniRef50_D1C3C2 Methylenetetrahydrofolate dehydrogenase (NADP(+)... 311 3e-83 UniRef50_C4Z3I2 Methylenetetrahydrofolate dehydrogenase (NADP+) ... 309 8e-83 UniRef50_C6CV64 Methylenetetrahydrofolate dehydrogenase (NADP(+)... 309 9e-83 UniRef50_C4FZX7 Putative uncharacterized protein n=1 Tax=Abiotro... 308 1e-82 UniRef50_O65269 F6N23.28 protein n=1 Tax=Arabidopsis thaliana Re... 308 2e-82 UniRef50_B2KB67 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 307 3e-82 UniRef50_UPI00017F08E4 PREDICTED: similar to MGC137793 protein n... 306 4e-82 UniRef50_A8RJW5 Putative uncharacterized protein n=2 Tax=Clostri... 306 6e-82 UniRef50_B0VGJ7 FolD bifunctional protein n=1 Tax=Candidatus Clo... 306 6e-82 UniRef50_C8WXG8 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 305 1e-81 UniRef50_B9K850 Bifunctional protein folD n=1 Tax=Thermotoga nea... 305 1e-81 UniRef50_Q83FS2 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 304 2e-81 UniRef50_D2RNA3 Methylenetetrahydrofolate dehydrogenase (NADP(+)... 304 3e-81 UniRef50_C7MLE6 Methenyltetrahydrofolate cyclohydrolase /5,10-me... 304 3e-81 UniRef50_Q7TU81 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 303 4e-81 UniRef50_A5ILJ9 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=... 302 9e-81 UniRef50_Q0S375 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=... 302 1e-80 UniRef50_D1BP88 Tetrahydrofolate dehydrogenase/cyclohydrolase n=... 301 2e-80 UniRef50_Q21285 Dauer or aging adult overexpression protein 3, c... 301 3e-80 UniRef50_B7AQ13 Putative uncharacterized protein n=3 Tax=Bacteri... 300 3e-80 UniRef50_A9NE96 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 299 6e-80 UniRef50_B5YA73 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 299 6e-80 UniRef50_Q0SFQ8 Methenyltetrahydrofolate cyclohydrolase n=11 Tax... 297 2e-79 UniRef50_C8WAB5 Tetrahydrofolate dehydrogenase/cyclohydrolase n=... 297 2e-79 UniRef50_A5CF58 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 297 4e-79 UniRef50_C2L112 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 294 2e-78 UniRef50_UPI00006CCCC6 methylenetetrahydrofolate dehydrogenase n... 294 3e-78 UniRef50_C1FDF4 5,10-methylene-tetrahydrofolate dehydrogenase/cy... 292 1e-77 UniRef50_A9UXQ1 Predicted protein n=7 Tax=cellular organisms Rep... 291 1e-77 UniRef50_Q057D7 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=... 290 4e-77 UniRef50_Q54VK0 Methenyl tetrahydrofolate cyclohydrolase / NADP-... 289 9e-77 UniRef50_Q04FB7 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=... 287 4e-76 UniRef50_C5CI88 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 285 1e-75 UniRef50_B5IEC2 Tetrahydrofolate dehydrogenase/cyclohydrolase, N... 285 1e-75 UniRef50_C1BVL5 Bifunctional methylenetetrahydrofolate dehydroge... 284 2e-75 UniRef50_A4X776 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=... 284 2e-75 UniRef50_D1ITY4 Whole genome shotgun sequence of line PN40024, s... 284 3e-75 UniRef50_A0C3Q0 Chromosome undetermined scaffold_147, whole geno... 283 4e-75 UniRef50_B9CK25 Bifunctional protein FolD n=1 Tax=Atopobium rima... 282 1e-74 UniRef50_A0DMT9 Chromosome undetermined scaffold_57, whole genom... 282 1e-74 UniRef50_Q0AWX5 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 282 1e-74 UniRef50_B5Y9D1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 279 1e-73 UniRef50_C8WN84 Tetrahydrofolate dehydrogenase/cyclohydrolase n=... 277 3e-73 UniRef50_D2W298 Predicted protein n=2 Tax=Naegleria gruberi RepI... 277 4e-73 UniRef50_C8WUM8 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 277 4e-73 UniRef50_Q2JCX4 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=... 275 9e-73 UniRef50_Q1AVQ0 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 275 1e-72 UniRef50_B7QFP4 C1-tetrahydrofolate synthase, putative n=1 Tax=I... 275 1e-72 UniRef50_Q160C0 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=... 275 2e-72 UniRef50_UPI00003C8447 methylenetetrahydrofolate dehydrogenase/m... 274 3e-72 UniRef50_Q86F84 Clone ZZD1003 mRNA sequence n=2 Tax=Schistosoma ... 272 7e-72 UniRef50_B5RQK8 Methylenetetrahydrofolate dehydrogenase n=2 Tax=... 272 1e-71 UniRef50_C1MLD7 5,10-methylene-tetrahydrofolate dehydrogenase/cy... 272 1e-71 UniRef50_C4QA37 Formate-tetrahydrofolate ligase, putative n=1 Ta... 270 4e-71 UniRef50_Q6L046 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 268 1e-70 UniRef50_Q4A6B1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 267 4e-70 UniRef50_Q8EV80 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 265 1e-69 UniRef50_A7HMQ2 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 265 2e-69 UniRef50_Q979W3 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 263 6e-69 UniRef50_D1VQM8 Methylenetetrahydrofolate dehydrogenase (NADP(+)... 262 1e-68 UniRef50_A6LP88 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 261 2e-68 UniRef50_B9KZ23 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 261 2e-68 UniRef50_UPI00006CB712 tetrahydrofolate dehydrogenase/cyclohydro... 261 2e-68 UniRef50_Q1J118 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=... 260 3e-68 UniRef50_B7J0W5 Methenyltetrahydrofolate cyclohydrolase n=22 Tax... 259 6e-68 UniRef50_C4XED5 Putative uncharacterized protein n=1 Tax=Mycopla... 259 7e-68 UniRef50_D1B5M7 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 255 9e-67 UniRef50_Q4DH06 Methylenetetrahydrofolate dehydrogenase-like pro... 254 3e-66 UniRef50_A5IXS7 FolD bifunctional protein(Methylenetetrahydrofol... 253 4e-66 UniRef50_Q4RT28 Chromosome 12 SCAF14999, whole genome shotgun se... 252 1e-65 UniRef50_D1VRZ1 Bifunctional protein FolD n=1 Tax=Peptoniphilus ... 246 8e-64 UniRef50_UPI00003BDED9 hypothetical protein DEHA0E19294g n=2 Tax... 245 1e-63 UniRef50_A7AXK7 Putative uncharacterized protein n=1 Tax=Ruminoc... 244 2e-63 UniRef50_Q6KID0 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 242 9e-63 UniRef50_D1J7X9 Methylenetetrahydrofolate dehydrogenase n=1 Tax=... 242 1e-62 UniRef50_B3PMJ8 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 239 7e-62 UniRef50_A9BIV9 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=... 237 2e-61 UniRef50_P47259 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 237 5e-61 UniRef50_Q5IWX9 Plastid 5,10-methylene-tetrahydrofolate dehydrog... 233 7e-60 UniRef50_Q98QV3 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 230 6e-59 UniRef50_A1RQQ5 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=... 229 6e-59 UniRef50_Q0AZF5 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=... 228 2e-58 UniRef50_C7GZF5 FolD protein n=1 Tax=Eubacterium saphenum ATCC 4... 223 5e-57 UniRef50_UPI00016B2244 FolD bifunctional protein n=2 Tax=candida... 220 4e-56 UniRef50_B8ZZU9 Putative uncharacterized protein MTHFD2 n=2 Tax=... 218 2e-55 UniRef50_A8IQS8 Methylenetetrahydrofolate dehydrogenase/ methyle... 215 1e-54 UniRef50_UPI0001B58450 methylenetetrahydrofolate dehydrogenase/m... 213 6e-54 UniRef50_B0RZW6 Methylenetetrahydrofolate dehydrogenase n=2 Tax=... 213 6e-54 UniRef50_B3QMF3 Tetrahydrofolate dehydrogenase/cyclohydrolase n=... 213 6e-54 UniRef50_B8BYF8 Predicted protein n=1 Tax=Thalassiosira pseudona... 210 6e-53 UniRef50_D1Z754 Whole genome shotgun sequence assembly, scaffold... 206 8e-52 UniRef50_A9EVL6 Methylenetetrahydrofolate dehydrogenase (NAD(+))... 205 2e-51 UniRef50_Q7NAE4 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=... 202 1e-50 UniRef50_Q02046 Methylenetetrahydrofolate dehydrogenase [NAD+] n... 200 5e-50 UniRef50_UPI000194D930 PREDICTED: methylene tetrahydrofolate deh... 200 7e-50 UniRef50_C4QVL0 NAD-dependent 5,10-methylenetetrahydrafolate deh... 197 4e-49 UniRef50_Q6UB35 Monofunctional C1-tetrahydrofolate synthase, mit... 195 1e-48 UniRef50_Q86KU6 Methylenetetrahydrofolate dehydrogenase [NAD+] n... 191 2e-47 UniRef50_Q4PBA5 Putative uncharacterized protein n=3 Tax=Basidio... 191 2e-47 UniRef50_B0CXH2 Predicted protein n=1 Tax=Laccaria bicolor S238N... 191 2e-47 UniRef50_C7HUG7 Bifunctional protein FolD protein n=1 Tax=Anaero... 191 3e-47 UniRef50_Q9XYB0 PugilistDominant (Fragment) n=2 Tax=Eukaryota Re... 190 5e-47 UniRef50_C7RD94 Tetrahydrofolate dehydrogenase/cyclohydrolase n=... 187 3e-46 UniRef50_Q4S6Y9 Chromosome 14 SCAF14723, whole genome shotgun se... 183 5e-45 UniRef50_A6QZK7 Putative uncharacterized protein n=1 Tax=Ajellom... 183 7e-45 UniRef50_B7G8Y9 Predicted protein (Fragment) n=8 Tax=Eukaryota R... 176 1e-42 UniRef50_Q5KEZ0 Methylenetetrahydrofolate dehydrogenase (NAD+), ... 175 1e-42 UniRef50_D0NPK1 Methylenetetrahydrofolate dehydrogenase [NAD+], ... 175 2e-42 UniRef50_B8NT34 Methylenetetrahydrofolate dehydrogenase, putativ... 173 5e-42 UniRef50_B5GAQ6 Tetrahydrofolate dehydrogenase/cyclohydrolase n=... 168 2e-40 UniRef50_Q0UVW9 Putative uncharacterized protein n=1 Tax=Phaeosp... 166 8e-40 UniRef50_B1AIX6 Methylenetetrahydrofolate dehydrogenase n=15 Tax... 163 6e-39 UniRef50_UPI000023D48A hypothetical protein FG10624.1 n=1 Tax=Gi... 161 2e-38 UniRef50_A8ZN24 Putative uncharacterized protein n=1 Tax=Acaryoc... 155 1e-36 UniRef50_B8BT80 Methylenetetrahydrofolate dehydrogenase (Fragmen... 152 2e-35 UniRef50_B6WAQ3 Putative uncharacterized protein n=1 Tax=Anaeroc... 151 2e-35 UniRef50_B5Y3N3 Predicted protein n=1 Tax=Phaeodactylum tricornu... 150 7e-35 UniRef50_Q3M1J6 Tetrahydrofolate dehydrogenase/cyclohydrolase n=... 148 3e-34 UniRef50_Q5PNN5 Novel protein similar to methylenetetrahydrofola... 141 3e-32 UniRef50_UPI0000D9A063 PREDICTED: similar to Bifunctional methyl... 135 2e-30 UniRef50_A6BAZ7 Fold bifunctional protein (Ppdc) (Fragment) n=1 ... 127 5e-28 UniRef50_B4FJK4 Putative uncharacterized protein n=1 Tax=Zea may... 123 5e-27 UniRef50_A4HZR2 Methylenetetrahydrofolate dehydrogenase-like pro... 120 5e-26 UniRef50_UPI00005A5066 PREDICTED: similar to Bifunctional methyl... 116 8e-25 UniRef50_B9PLA1 Methylenetetrahydrofolate dehydrogenase, putativ... 115 2e-24 UniRef50_C0Z3J6 AT2G38660 protein n=2 Tax=Arabidopsis thaliana R... 113 5e-24 UniRef50_UPI0001904966 Methenyltetrahydrofolate cyclohydrolase n... 113 7e-24 UniRef50_B6FPJ6 Putative uncharacterized protein n=1 Tax=Clostri... 112 2e-23 UniRef50_A1ZUI3 Tetrahydrofolate dehydrogenase/cyclohydrolase, N... 109 1e-22 UniRef50_Q6X5D4 Methylene-THF dehydrogenase (Fragment) n=1 Tax=T... 95 3e-18 UniRef50_D0NV87 Tetrahydrofolate dehydrogenase n=7 Tax=Phytophth... 91 3e-17 UniRef50_D0NYB3 Tetrahydrofolate dehydrogenase n=1 Tax=Phytophth... 83 9e-15 UniRef50_B3L796 Putative uncharacterized protein n=2 Tax=Plasmod... 76 1e-12 UniRef50_C6KTE2 Putative uncharacterized protein n=1 Tax=Plasmod... 68 4e-10 UniRef50_C7YLA7 Predicted protein n=1 Tax=Nectria haematococca m... 63 2e-08 UniRef50_UPI00015563B5 PREDICTED: similar to Mthfd2-prov protein... 56 1e-06 UniRef50_A4YD89 Glutamyl-tRNA reductase n=1 Tax=Metallosphaera s... 55 3e-06 UniRef50_Q4YPQ5 Putative uncharacterized protein n=4 Tax=Plasmod... 51 3e-05 UniRef50_D0YQ76 Bifunctional protein FolD 2 (Fragment) n=2 Tax=c... 49 2e-04 UniRef50_Q0IEF9 Putative uncharacterized protein n=1 Tax=Aedes a... 48 3e-04 Sequences not found previously or not previously below threshold: UniRef50_A4FH75 Ornithine/acetylornithine aminotransferase n=6 T... 51 7e-05 UniRef50_C8WWK0 Dipicolinic acid synthetase, A subunit n=2 Tax=A... 50 9e-05 UniRef50_C1XXU4 Predicted dehydrogenase n=1 Tax=Meiothermus silv... 48 5e-04 UniRef50_B5Y9H6 Shikimate / quinate 5-dehydrogenase domain prote... 48 6e-04 UniRef50_B1I1H2 Shikimate/quinate 5-dehydrogenase n=22 Tax=Clost... 47 7e-04 UniRef50_C3YVA9 Putative uncharacterized protein n=1 Tax=Branchi... 47 8e-04 UniRef50_B0PHV3 Putative uncharacterized protein n=2 Tax=Bacteri... 46 0.002 UniRef50_C8W3U8 Shikimate/quinate 5-dehydrogenase n=1 Tax=Desulf... 46 0.002 UniRef50_B3DT49 S-adenosylhomocysteine hydrolase n=10 Tax=Bifido... 46 0.002 UniRef50_B1Z0C8 Short-chain dehydrogenase/reductase SDR n=4 Tax=... 46 0.002 UniRef50_C3Y6A1 Putative uncharacterized protein n=1 Tax=Branchi... 45 0.003 UniRef50_Q8SU39 Similarity to HYPOTHETICAL OXIDOREDUCTASE YAEB_S... 45 0.003 UniRef50_C6M1U6 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydro... 45 0.003 UniRef50_B5IQA9 Glycerate dehydrogenase n=1 Tax=Cyanobium sp. PC... 45 0.003 UniRef50_C6P544 Biotin/acetyl-CoA-carboxylase ligase n=1 Tax=Sid... 44 0.004 UniRef50_C2M1R4 Putative uncharacterized protein n=1 Tax=Capnocy... 44 0.004 UniRef50_Q3ACY7 Dipicolinate synthase, A subunit n=1 Tax=Carboxy... 44 0.004 UniRef50_B9J9W2 Adenosylhomocysteinase protein n=6 Tax=Bacteria ... 44 0.005 UniRef50_A8L9A5 S-adenosyl-L-homocysteine hydrolase n=1 Tax=Fran... 44 0.005 UniRef50_O29376 S-adenosylhomocysteinase hydrolase (AhcY-1) n=1 ... 44 0.005 UniRef50_A6NPY8 Putative uncharacterized protein n=1 Tax=Bactero... 43 0.009 UniRef50_A5MC89 Putative uncharacterized protein n=1 Tax=Strepto... 43 0.012 >UniRef50_A0LE04 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Proteobacteria RepID=FOLD_MAGSM Length = 285 Score = 400 bits (1028), Expect = e-110, Method: Composition-based stats. Identities = 151/283 (53%), Positives = 198/283 (69%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A +IDGK IAQ VR E+ +V+ PGLAVVLVG++PASQ+YV +K++ACE Sbjct: 1 MAHVIDGKAIAQSVREELRMEVERLKLNHQLTPGLAVVLVGADPASQVYVRNKKRACETA 60 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S S++L TTS+AELL LI+ LN D+ + GILVQLPLP ID KVLE I P KD D Sbjct: 61 GIASFSHELAATTSQAELLALIEQLNQDDAVHGILVQLPLPKHIDEQKVLEAISPSKDAD 120 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GFHPYNVGRL P +PCTP G++ +L+ +D G +AVVIG SNIVG+P+++ LL Sbjct: 121 GFHPYNVGRLVTGDPTFQPCTPWGVMEMLKVSGVDPKGKHAVVIGRSNIVGKPVALMLLA 180 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 A T T+ H T +L V+ AD+++ AVG+ +PG WIK+GA+VIDVGINR E+GK+ Sbjct: 181 AHATVTICHSRTPDLAETVKRADIVVAAVGRANMVPGSWIKKGAVVIDVGINRGEDGKLC 240 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 GDV + + AS ITPVPGGVGPMT+A L++NT++ H+ Sbjct: 241 GDVDYASCFEHASAITPVPGGVGPMTIAMLLKNTVEGAKRAHN 283 >UniRef50_Q0AB42 Methenyltetrahydrofolate cyclohydrolase n=19 Tax=cellular organisms RepID=FOLD_ALHEH Length = 286 Score = 384 bits (988), Expect = e-105, Method: Composition-based stats. Identities = 169/282 (59%), Positives = 215/282 (76%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M+A+I+DGK IA ++R +V ++V+AR+ G R PGLAVVLVG++PAS +YV KR+ACE+ Sbjct: 1 MSAQILDGKAIAAELREQVRKQVEARVERGGRRPGLAVVLVGADPASTVYVGKKRQACEQ 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G S +++LP T++ ELL L+D LN + IDGILVQLPLP ID V++RIHPDKDV Sbjct: 61 LGMHSSAHELPAETTQDELLALVDELNGRDEIDGILVQLPLPDHIDEQTVIDRIHPDKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP N+GRL R P LRPCTP G++T+L I+ G +AV+IG SNIVGRPM+MELL Sbjct: 121 DGFHPVNMGRLTLRLPGLRPCTPNGVMTMLAHAGIELEGKDAVIIGQSNIVGRPMAMELL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 A CT T+ H T+NL V AD+++ AVG+PGF+PGDWIK GA+VIDVGINRLE+GK+ Sbjct: 181 NARCTITICHSRTRNLADRVRAADIVVAAVGRPGFVPGDWIKPGAVVIDVGINRLESGKL 240 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 GDV F A + A +ITPVPGGVGPMTVATL+ NTL A Sbjct: 241 TGDVDFAAARELAGWITPVPGGVGPMTVATLMANTLAAAEAR 282 >UniRef50_O65271 F6N23.26 protein n=34 Tax=Viridiplantae RepID=O65271_ARATH Length = 360 Score = 377 bits (969), Expect = e-103, Method: Composition-based stats. Identities = 136/292 (46%), Positives = 185/292 (63%), Gaps = 8/292 (2%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A +IDGK +A+++R E+ +V + PGLAV+LVG S YV +K+KAC+ VG Sbjct: 69 AIVIDGKAVAKKIRDEITIEVSRMKESIGVIPGLAVILVGDRKDSATYVRNKKKACDSVG 128 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 S L E +SE E+L+ + N D ++ GILVQLPLP+ +D +L + +KDVDG Sbjct: 129 IKSFEVRLAEDSSEEEVLKSVSGFNDDPSVHGILVQLPLPSHMDEQNILNAVSIEKDVDG 188 Query: 123 FHPYNVGRLCQ--RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 FHP N+GRL R P PCTP+G + LL RYNI+ G AVVIG SNIVG P ++ L Sbjct: 189 FHPLNIGRLAMRGREPLFVPCTPKGCIELLHRYNIEIKGKRAVVIGRSNIVGMPAALLLQ 248 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-- 238 T ++ H TKN AD++I AVG+P + G WIK GA++IDVGIN +E+ Sbjct: 249 REDATVSIIHSRTKNPEEITREADIIISAVGQPNMVRGSWIKPGAVLIDVGINPVEDPSA 308 Query: 239 ----KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 ++VGD+ +E+A+K AS ITPVPGGVGPMT+A L+ NTL + H+ Q Sbjct: 309 ARGYRLVGDICYEEASKVASAITPVPGGVGPMTIAMLLSNTLTSAKRIHNFQ 360 >UniRef50_A7MT09 Methenyltetrahydrofolate cyclohydrolase n=64 Tax=cellular organisms RepID=FOLD_VIBHB Length = 286 Score = 375 bits (963), Expect = e-102, Method: Composition-based stats. Identities = 208/286 (72%), Positives = 246/286 (86%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A+ IDG I+Q VRSEVA +V+AR+ AGLRAPGLAVVLVG +PASQ+YV SKR+ACEE Sbjct: 1 MTAQNIDGTLISQTVRSEVAARVKARVEAGLRAPGLAVVLVGEDPASQVYVGSKRRACEE 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VGFVS+S+DLP TTSE ELL LID LN D IDGILVQLPLPAGID VLERIHP+KDV Sbjct: 61 VGFVSKSFDLPATTSEEELLALIDELNNDAEIDGILVQLPLPAGIDATHVLERIHPEKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHPYNVGRL QR P+LR CTP+GI+TLL+RYNI+ G +AVV+GASNIVGRPM++ELL Sbjct: 121 DGFHPYNVGRLAQRIPKLRSCTPKGIITLLDRYNIELRGKHAVVVGASNIVGRPMTLELL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 LAGCTTT HRFTK+L HV ADL++VAVGKP FIPG+WIK+GA+V+DVGINRLE+GK+ Sbjct: 181 LAGCTTTTCHRFTKDLEGHVRQADLVVVAVGKPNFIPGEWIKKGAVVVDVGINRLESGKL 240 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 VGDV ++ A + AS+ITPVPGGVGPMTVA+LIENT+ AC ++H + Sbjct: 241 VGDVEYDKARENASFITPVPGGVGPMTVASLIENTMLACEQFHTKK 286 >UniRef50_A3DEE6 Methenyltetrahydrofolate cyclohydrolase n=6 Tax=Bacteria RepID=FOLD_CLOTH Length = 285 Score = 374 bits (961), Expect = e-102, Method: Composition-based stats. Identities = 147/282 (52%), Positives = 195/282 (69%), Gaps = 1/282 (0%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M AK+++GK ++ +++ E+ +V+ PGLAV++VG++PAS++YV SK+KAC E Sbjct: 1 MEAKVLNGKELSTKIKEELKIEVEDLK-KNNINPGLAVIIVGNDPASRVYVNSKKKACAE 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G S Y L E T++ EL+ELI LN D+ + GILVQLPLP ID KV+ I P KDV Sbjct: 60 IGIESFEYALEENTTQEELIELIHKLNKDDKVSGILVQLPLPKHIDEEKVIYAIDPSKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 D FHP NVG+L P PCTP G++ L++ ID G VV+G SNIVG+PM+M LL Sbjct: 120 DAFHPVNVGKLMIGNPDFLPCTPAGVMELIKESGIDITGKECVVVGRSNIVGKPMAMLLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T TV H T+N+ + AD+L+VAVGKP FI G IK GA+VIDVGINRLEN K+ Sbjct: 180 AQNGTVTVCHSRTQNIDEVCKRADILVVAVGKPEFIKGSSIKPGAVVIDVGINRLENKKL 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 VGDV +E A++ AS ITPVPGGVGPMT+A L++NT++A Sbjct: 240 VGDVEYESASRVASAITPVPGGVGPMTIAMLMKNTVKAAKLQ 281 >UniRef50_A5F6V4 Methenyltetrahydrofolate cyclohydrolase n=270 Tax=Bacteria RepID=FOLD_VIBC3 Length = 286 Score = 373 bits (957), Expect = e-102, Method: Composition-based stats. Identities = 202/283 (71%), Positives = 240/283 (84%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A+ IDG I+Q VRSEVA +V+AR+ AGLRAPGLAVVLVG +PASQ+YV SKR+ACEE Sbjct: 1 MTAQNIDGTLISQTVRSEVAARVKARVQAGLRAPGLAVVLVGEDPASQVYVGSKRRACEE 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VGFVS+S+DLP T SE LL L++ LN D IDGILVQLPLPAG+D KVLE IHP+KDV Sbjct: 61 VGFVSKSFDLPATASEEALLSLVEELNNDPQIDGILVQLPLPAGMDTTKVLESIHPEKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHPYNVGRL QR P+LR CTP+GI+TLLERYNI G +AV++GASNIVGRPM++ELL Sbjct: 121 DGFHPYNVGRLAQRIPKLRSCTPKGIITLLERYNIPLRGKHAVIVGASNIVGRPMTLELL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 LAGCTTT HRFT++L H+ AD+L+VAVGKP FIPG WIKEGA+V+DVGINRL+ GK+ Sbjct: 181 LAGCTTTTCHRFTQDLEGHIRQADILVVAVGKPNFIPGAWIKEGAVVVDVGINRLDTGKL 240 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 VGDV ++ A RAS+ITPVPGGVGPMTVA+LIENT+ AC ++H Sbjct: 241 VGDVEYDVARTRASFITPVPGGVGPMTVASLIENTMMACEQFH 283 >UniRef50_Q82XC3 Methenyltetrahydrofolate cyclohydrolase n=7 Tax=Proteobacteria RepID=FOLD_NITEU Length = 295 Score = 371 bits (953), Expect = e-101, Method: Composition-based stats. Identities = 134/281 (47%), Positives = 177/281 (62%), Gaps = 1/281 (0%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M+A II G IA + R E+ Q+V+ + PGLAV+L G NPAS +YV +K K CEE Sbjct: 1 MSATIISGSLIASKFREELKQRVKIL-SETWMQPGLAVILAGDNPASCVYVRNKAKTCEE 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G S ++ P S+ LL+ I LN + I GILVQLPLP I +V+ I KDV Sbjct: 60 LGIRSEIFNFPGDISQKALLQQIQDLNVNPEIHGILVQLPLPGHIRIDEVIAAIAIGKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP NVG L PCTP G++ +L Y+I G +AV+IG SNIVG+PM++ LL Sbjct: 120 DGFHPCNVGALVTGHALFHPCTPFGVMKMLAEYDIPLQGQHAVIIGRSNIVGKPMALMLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 G T TV T++L H NAD++++A GK + D I+ GA VIDVGINRL +G++ Sbjct: 180 EKGATVTVCTSRTRDLASHTRNADIVVMAAGKANLLTSDMIRTGATVIDVGINRLADGRL 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 GDV F ++A YITPVPGGVGPMT+ L+ NT++A Sbjct: 240 CGDVEFSGVKEKAGYITPVPGGVGPMTIVMLMNNTIEAAER 280 >UniRef50_Q2JQ25 Methenyltetrahydrofolate cyclohydrolase n=8 Tax=cellular organisms RepID=FOLD_SYNJB Length = 293 Score = 363 bits (933), Expect = 3e-99, Method: Composition-based stats. Identities = 140/288 (48%), Positives = 184/288 (63%), Gaps = 4/288 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M AKI+DGK +A ++++E+A +VQA I R PGLAV+ VG +PAS YV K +ACE Sbjct: 1 MPAKILDGKALAARLQAEMAAQVQAWIPQVGRPPGLAVLRVGEDPASAAYVRGKERACER 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G S S A LL+ ID LN D +DGILVQLPLP G D + L I+PDKDV Sbjct: 61 LGIASFGRHFSAQDSPAHLLDTIDQLNQDERVDGILVQLPLPPGWDPIPPLLAINPDKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG HP N+GRL + P LR CTP G++ LL+ I G AVV+G S +VG+P+S+ LL Sbjct: 121 DGLHPLNLGRLLRGEPGLRSCTPLGVMRLLQAEGIPIAGRKAVVVGRSILVGKPLSLMLL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-- 238 A T T+ H T +L AD++++AVG+P + D +K GA+VIDVGINR+E Sbjct: 181 AADATVTLAHSRTPDLAEVTRAADIVVMAVGRPRLLRADMVKPGAVVIDVGINRIETPTG 240 Query: 239 --KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 ++VGDV +E + A+ ITPVPGGVGPMTV L+ NTLQ+ Sbjct: 241 AEQLVGDVDYEAVKELAAAITPVPGGVGPMTVTMLLANTLQSYKLRSH 288 >UniRef50_B8HXS0 Methenyltetrahydrofolate cyclohydrolase n=25 Tax=cellular organisms RepID=FOLD_CYAP4 Length = 293 Score = 363 bits (931), Expect = 5e-99, Method: Composition-based stats. Identities = 138/285 (48%), Positives = 189/285 (66%), Gaps = 4/285 (1%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 ++DGK +AQ++++++ +VQA R PGLAV++VG NPAS YV +K +ACE+VG Sbjct: 7 NLLDGKALAQEMQADLTLQVQALQTRVGRPPGLAVLMVGDNPASAAYVRNKERACEQVGI 66 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S + LP T++AELL LI+ LN D +DGILVQLPLP +D +L I P KD DG Sbjct: 67 ASFGHHLPTETTQAELLTLINQLNQDPRVDGILVQLPLPNHLDARALLYAIDPTKDADGL 126 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 HP N+GRL + P LR CTP G++ LL++YNI+ G AVVIG S +VG+P++M LL A Sbjct: 127 HPENLGRLVRSEPGLRSCTPAGVMRLLQKYNIELRGKEAVVIGRSILVGKPLAMMLLEAD 186 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN----GK 239 T T+ H + +L AD+LI AVGKPG + +K GA+V+DVGINR+ + Sbjct: 187 ATVTIAHSRSTDLAEIARRADILIAAVGKPGLVSAGMVKAGAVVVDVGINRVVEATGKSR 246 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 +VGDV F A YITPVPGG+GPMTVA L++NT+ + + + Sbjct: 247 LVGDVDFAAVQPIAGYITPVPGGIGPMTVAMLLDNTVCSFQQRNG 291 >UniRef50_B5YJV1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=FOLD_THEYD Length = 286 Score = 361 bits (927), Expect = 2e-98, Method: Composition-based stats. Identities = 141/284 (49%), Positives = 195/284 (68%), Gaps = 1/284 (0%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M+A+I+DGK++A +++ E+ ++VQ P LAVVLVG N +SQ YV+ K K C+E Sbjct: 1 MSAEILDGKSLALKIKEELKKEVQDLKNQ-GINPCLAVVLVGENKSSQKYVSFKEKTCKE 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 + S + LPE T E L++LID LN ++ ++GIL+QLPLP ++ KVLERI+P KDV Sbjct: 60 LDIQSLVFKLPENTEETSLIKLIDELNENSQVNGILIQLPLPKHLNQNKVLERINPFKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGF P+ +GRL +P PCTP+GI+ +L+ Y I+ G AVVIG S IVG+P+S+ LL Sbjct: 120 DGFTPFCLGRLLIDSPLFIPCTPKGIIRMLDEYKINLEGKQAVVIGRSIIVGKPLSLLLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T T+ H T NL+ + AD+L VA+G+ FI + IK+GA+VID+GIN +GKV Sbjct: 180 KRNATVTMCHSKTINLQDITKKADILCVAIGREKFITSNMIKKGAVVIDIGINVTASGKV 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 VGDV F+D ++ASYITPVPGGVGPMT+A L+EN + A Sbjct: 240 VGDVNFDDVKEKASYITPVPGGVGPMTIAMLMENAIYAAKLQKR 283 >UniRef50_A8JH65 5,10-methylenetetrahydrofolate dehydrogenase n=4 Tax=cellular organisms RepID=A8JH65_CHLRE Length = 340 Score = 360 bits (925), Expect = 3e-98, Method: Composition-based stats. Identities = 143/294 (48%), Positives = 182/294 (61%), Gaps = 8/294 (2%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A+K+IDGK IA +RSE+A +V PGLAVVLVG+ S+ YV SK+KAC EV Sbjct: 44 ASKLIDGKGIADTIRSEIATEVADMKKQYGLTPGLAVVLVGARKDSETYVRSKKKACAEV 103 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 GF S DLP SE ELL+++ NAD + GILVQLPLP I ++L+ I DKDVD Sbjct: 104 GFDSFGTDLPADVSEEELLKVVAAYNADPRVHGILVQLPLPKHISEKRILDAISIDKDVD 163 Query: 122 GFHPYNVGRLCQ--RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 GFHP N+G L R P PCTP+G + LLER + G A VIG SNIVG P ++ L Sbjct: 164 GFHPLNIGCLAMRGRDPLFVPCTPKGCIELLERMKVPIAGKKACVIGRSNIVGMPAALLL 223 Query: 180 LLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN-- 237 T T+ H T + + AD++I A G + GDWIK GA+VIDVGIN ++ Sbjct: 224 QRRDATVTMVHSKTPDAKKICSEADIVIAACGVAEMVTGDWIKPGAVVIDVGINAKDDAT 283 Query: 238 ----GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQD 287 ++VGDV FE AA +AS ITPVPGGVGPMT+A L++NTL++ + Sbjct: 284 QKKGYRLVGDVEFEGAAAKASLITPVPGGVGPMTIAMLLQNTLESARRAAKGEK 337 >UniRef50_C4FUB1 Putative uncharacterized protein n=1 Tax=Catonella morbi ATCC 51271 RepID=C4FUB1_9FIRM Length = 294 Score = 356 bits (914), Expect = 5e-97, Method: Composition-based stats. Identities = 129/279 (46%), Positives = 174/279 (62%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 +DGKT++Q + + ++Q A + P L V+ VG +PAS++YV K+K E+G+ Sbjct: 4 LDGKTLSQSIFARLSQATAAFRSQTGTQPKLTVISVGEDPASKVYVGQKQKRALEIGYAF 63 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 LP S+ EL I N D G+L+QLPLP +D + + I P+KDVDGFHP Sbjct: 64 EWMLLPADISQEELERTIKVHNQDPQTHGLLLQLPLPDHLDPLSAMHLIDPEKDVDGFHP 123 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCT 185 +GR+ + L PCTP+GIV LLE I G N VV+G S IVG P+S+ L+ G T Sbjct: 124 LTMGRVVEDNTDLYPCTPKGIVRLLENAQIPLQGQNVVVVGRSQIVGLPISIMLINRGAT 183 Query: 186 TTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVV 245 TV + T++L H+ AD+LIVA G+ I D +KEGA+V+DVGINRL +GK+VGDV Sbjct: 184 VTVCNSKTQDLGHYTRYADILIVATGQAHLIGPDHLKEGAVVVDVGINRLMSGKLVGDVD 243 Query: 246 FEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 FE A + SYITPVPGGVGPMTVA L+E T + + Sbjct: 244 FEAVAHKVSYITPVPGGVGPMTVAMLMEQTFTCACQQQN 282 >UniRef50_Q46A53 Methenyltetrahydrofolate cyclohydrolase n=13 Tax=cellular organisms RepID=FOLD_METBF Length = 287 Score = 356 bits (914), Expect = 6e-97, Method: Composition-based stats. Identities = 129/279 (46%), Positives = 184/279 (65%), Gaps = 1/279 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 ++IIDGK +A+++ EV V+A ++ PGLA VLVG +PAS++YV K +ACE V Sbjct: 7 ESRIIDGKVLAKKIEDEVRSGVEALVSGRGITPGLATVLVGDDPASKMYVRLKHRACERV 66 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + + LP TS+ EL+ LI+TLN D + GIL+QLPLP + + +E I P+KD D Sbjct: 67 GIQAEDHFLPAETSQEELISLINTLNKDQNVHGILLQLPLPKHLFPQEAMEAIAPEKDAD 126 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GFHPYN+G+L L PCTP G++ LE YN+ G N V++G SN+VG+P++ L Sbjct: 127 GFHPYNMGKLMIGDEGLVPCTPHGVIRALEEYNVPVKGKNVVIVGHSNVVGKPLAAMFLN 186 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 T +V H FT +L+ + +AD+L+VA G I D +KEGA++ DVGI + ++G V Sbjct: 187 RNATVSVCHVFTDDLKKYTLDADILVVATGVKHLIKADMVKEGAVIFDVGITKEKDG-VY 245 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 GDV FE+ K+A+ ITPVPGGVGP+TVA L+++ L Sbjct: 246 GDVDFENVIKKAALITPVPGGVGPLTVAMLMKHVLGCAE 284 >UniRef50_Q8LEA3 5,10-methylenetetrahydrofolate dehydrogenase:5,10-methenyltetrahydrofolate cyclohydrolase, putative n=9 Tax=Eukaryota RepID=Q8LEA3_ARATH Length = 299 Score = 355 bits (912), Expect = 9e-97, Method: Composition-based stats. Identities = 142/292 (48%), Positives = 181/292 (61%), Gaps = 8/292 (2%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 AKIIDGK IA +RSE+A++V+ + PGLAVV+VGS SQ YV +KRKAC EV Sbjct: 8 TAKIIDGKAIAHTIRSEIAEEVRGLSEKHGKVPGLAVVIVGSRKDSQTYVNTKRKACAEV 67 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S LPE SEA+L+ + LN++ + GILVQLPLP I+ +L I DKDVD Sbjct: 68 GIKSFDVGLPEEVSEADLISKVHELNSNPDVHGILVQLPLPKHINEENILGAISIDKDVD 127 Query: 122 GFHPYNVGRLCQ--RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 GFHP N+G+L R P PCTP+G + LL R + G AVV+G SNIVG P+S+ L Sbjct: 128 GFHPLNIGKLAMKGREPLFLPCTPKGCLELLARSGVKIKGQRAVVVGRSNIVGLPVSLLL 187 Query: 180 LLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG- 238 L A T T H TK+ + AD++I A G+ I G+WIK GA VIDVG N + + Sbjct: 188 LKADATVTTVHSHTKDPEAIIREADIVIAACGQAHMIKGNWIKPGAAVIDVGTNAVSDPS 247 Query: 239 -----KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDP 285 ++VGDV F +A+K A +ITPVPGGVGPMTVA L+ NT+ Sbjct: 248 KKSGYRLVGDVDFAEASKVAGFITPVPGGVGPMTVAMLLRNTVDGAKRVFGE 299 >UniRef50_Q6GI21 Methenyltetrahydrofolate cyclohydrolase n=83 Tax=Bacteria RepID=FOLD_STAAR Length = 286 Score = 354 bits (910), Expect = 1e-96, Method: Composition-based stats. Identities = 131/287 (45%), Positives = 188/287 (65%), Gaps = 1/287 (0%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M AKI+DGK IA+ R + +V+A P L+V+LVG++ ASQ YV SK+KA E+ Sbjct: 1 MVAKILDGKQIAKDYRQGLQNQVEALKEK-GFTPKLSVILVGNDGASQSYVRSKKKAAEK 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G +S L ET +E E+L ++ LN D+++ GILVQ+PLP + K+LE I+PDKDV Sbjct: 60 IGMISEIVHLEETATEEEVLNELNRLNNDDSVSGILVQVPLPKQVSEQKILEAINPDKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP N+G+L PCTP GI+ +L+ +ID G NAVVIG S+IVG+P+S LL Sbjct: 120 DGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEGKNAVVIGRSHIVGQPVSKLLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 + T+ H +K++ ++++AD+++ AVGKPG + D +KEGA++IDVG ENGK+ Sbjct: 180 QKNASVTILHSRSKDMASYLKDADVIVSAVGKPGLVTKDVVKEGAVIIDVGNTPDENGKL 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQD 287 GDV ++ + A ITPVPGGVGP+T+ ++ NTL A Sbjct: 240 KGDVDYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLAEKMRRGIDS 286 >UniRef50_D2QZP8 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2QZP8_9PLAN Length = 293 Score = 352 bits (904), Expect = 8e-96, Method: Composition-based stats. Identities = 139/291 (47%), Positives = 179/291 (61%), Gaps = 10/291 (3%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M +IDG+ I + + E+A++V I RAP LA VLVG +PAS +YV +K ACE Sbjct: 1 MTHVVIDGRAIGRVIELEIAEQVADFIQNNGRAPCLAAVLVGDDPASAVYVKNKHLACER 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG S+ + L +TSE ELL+LI LN D I GILVQLPLP+ I + VL+ +HP KDV Sbjct: 61 VGIESKLHRLAGSTSEEELLDLIAMLNDDPAISGILVQLPLPSQIRSTYVLDAVHPLKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 D FHP NVG L Q PR PCTP G + +L R + G + ++G S+IVGRP++ L Sbjct: 121 DCFHPENVGLLTQGRPRYLPCTPHGCLQILHRTGLSVAGKHVAIVGRSDIVGRPLATLLS 180 Query: 181 LA---------GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVG 231 T T+ H +KNL AD+LI A+GKP F+ D +K GAIVIDVG Sbjct: 181 QKDSHLSPEICNATVTLLHSRSKNLAAMTREADVLIAAIGKPKFVTADMVKPGAIVIDVG 240 Query: 232 INRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 INRL G + GDV F+ A +SYITPVP GVGP+T+ L++NTL A Sbjct: 241 INRLPEG-LCGDVDFDSVAPISSYITPVPKGVGPLTITMLLQNTLAAARAQ 290 >UniRef50_B0KLM9 Methenyltetrahydrofolate cyclohydrolase n=184 Tax=Bacteria RepID=FOLD2_PSEPG Length = 303 Score = 352 bits (903), Expect = 9e-96, Method: Composition-based stats. Identities = 147/295 (49%), Positives = 185/295 (62%), Gaps = 8/295 (2%) Query: 1 MAA----KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRK 56 M A K+IDGK A +V +EV ++VQ G PGL VVLVG++ ASQ+YV +K Sbjct: 1 MNALTSLKLIDGKATAARVLAEVREQVQELR-QGGVQPGLVVVLVGADAASQVYVRNKVL 59 Query: 57 ACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHP 116 EEVG S+ + LP T++A LL LID LN D ++GILVQLPLPA ID VL+ I+P Sbjct: 60 RAEEVGIRSQEHRLPADTTQAHLLTLIDRLNRDPEVNGILVQLPLPAHIDEHCVLQAINP 119 Query: 117 DKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMS 176 KDVDGFH NVG L Q L PCTP G + LL + G +AVV+G SNIVG+PM+ Sbjct: 120 LKDVDGFHSENVGGLAQGRDVLTPCTPSGCMRLLRDACGELRGKHAVVVGRSNIVGKPMA 179 Query: 177 MELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE 236 LL A CT TV H +++L AD+L+ AVGKP I D +K GA+VIDVGINR+ Sbjct: 180 ALLLQADCTVTVVHSRSRDLPALCRQADILVAAVGKPRLIGADCLKPGAVVIDVGINRIN 239 Query: 237 N---GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQDE 288 +VGDV F A + + ITPVPGGVGPMT+A L++NTL A + Sbjct: 240 EDGQNHLVGDVDFAAALPQVAGITPVPGGVGPMTIAYLMKNTLLALDLQQQAAHQ 294 >UniRef50_A0K8R4 Methenyltetrahydrofolate cyclohydrolase n=254 Tax=cellular organisms RepID=FOLD_BURCH Length = 285 Score = 351 bits (902), Expect = 1e-95, Method: Composition-based stats. Identities = 145/281 (51%), Positives = 187/281 (66%), Gaps = 1/281 (0%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A +IDG +++ +R++ A++ A A PGLAV+LVG+NPAS++YV +K KACE+ Sbjct: 1 MTALLIDGNALSKTLRAQAAERAAALTAR-GHQPGLAVILVGANPASEVYVRNKIKACED 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 GF S P T SEA+LL ID LN D I GILVQLPLPA ID+ KV+E I P+KDV Sbjct: 60 NGFFSLKDAYPATLSEADLLARIDELNRDPKIHGILVQLPLPAHIDSHKVIEAIAPEKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFH N G L P RPCTP G++ + E + I G NAVVIG SNIVG+PM+M LL Sbjct: 120 DGFHVANAGALMTGKPLFRPCTPYGVMKMFEAHGIALQGANAVVIGRSNIVGKPMAMMLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 AG T T+ H T++L H AD+++ AVGK + D +K GA VIDVG+NR + GK+ Sbjct: 180 DAGATVTICHSKTRDLAAHTREADIVVAAVGKRNILTADMVKPGATVIDVGMNRDDAGKL 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 GDV F + A YITPVPGGVGPMT+ L+ NT+++ Sbjct: 240 CGDVDFAGVKEVAGYITPVPGGVGPMTITMLLINTIESAER 280 >UniRef50_A4XY05 Methenyltetrahydrofolate cyclohydrolase n=47 Tax=Proteobacteria RepID=FOLD3_PSEMY Length = 307 Score = 351 bits (900), Expect = 2e-95, Method: Composition-based stats. Identities = 148/283 (52%), Positives = 188/283 (66%), Gaps = 4/283 (1%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 K+IDGK A +V +EVA+ V+A AAG+ P LAVVLVG +PASQ+YV +K EE G Sbjct: 8 KLIDGKAAAARVLAEVAEDVRALKAAGIV-PALAVVLVGDDPASQVYVRNKVLRAEECGI 66 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S + LP T+EA L LI LNAD ++ GILVQLPLPA ID +VL+ + P KDVDGF Sbjct: 67 RSLEFKLPADTAEARLQALIAELNADASVHGILVQLPLPAHIDEQRVLQAVTPLKDVDGF 126 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 H NVG L Q L PCTP G + LL+ D G +AVVIG SNIVG+PM+ LL A Sbjct: 127 HAENVGGLSQGREVLTPCTPAGCLRLLQDSCGDLTGKHAVVIGRSNIVGKPMAALLLKAH 186 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN---GKV 240 C+ TV H + NL+ AD+++ AVG+P + DW+K GA+VIDVGINR++ ++ Sbjct: 187 CSVTVVHSKSANLKTLCRQADIVVAAVGRPRLVDADWLKPGAVVIDVGINRIDENGRSRL 246 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 VGDV F+ A + S ITPVPGGVGPMT+A L++NTL A Sbjct: 247 VGDVDFDSALPQVSAITPVPGGVGPMTIAYLMKNTLVAARLQQ 289 >UniRef50_B2V9R3 Methenyltetrahydrofolate cyclohydrolase n=14 Tax=Bacteria RepID=FOLD_SULSY Length = 285 Score = 349 bits (896), Expect = 6e-95, Method: Composition-based stats. Identities = 150/282 (53%), Positives = 199/282 (70%), Gaps = 3/282 (1%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 ++DGK++A+++++++ Q++ G R P L+V+LVG NPASQIYV K K C VG Sbjct: 2 ILLDGKSLAEKIKNQIKQEIDQLTQKGYRQPVLSVILVGENPASQIYVNKKIKDCASVGI 61 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S+ + LPE ++ ELLELI LN D +DGILVQLPLP+ I+ ++++E I+P KDVDGF Sbjct: 62 KSKPFFLPENITQTELLELIGDLNGDEEVDGILVQLPLPSHINTLEIIEAINPYKDVDGF 121 Query: 124 HPYNVGRLCQR-APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSME-LLL 181 HP NVG+L + PCTP GI+ LL YNID FG + VV+GASNIVG+PMS+ L Sbjct: 122 HPINVGKLATGRNDAILPCTPYGIMKLLHEYNIDHFGKDVVVVGASNIVGKPMSLLFLKD 181 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 T T+ H+ TK+L+ H AD+L+VAVGKP I D +KEGA+VIDVGINR+ +GK+V Sbjct: 182 EKSTVTICHKNTKDLKSHTLKADILVVAVGKPKLITEDMVKEGAVVIDVGINRV-DGKIV 240 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 GDV FE+ K+A ITPVPGGVGPMTVA L+ NTL+ Sbjct: 241 GDVDFENVKKKAYAITPVPGGVGPMTVAMLLYNTLEIYKRKL 282 >UniRef50_B0TFC9 Methenyltetrahydrofolate cyclohydrolase n=7 Tax=Clostridia RepID=FOLD_HELMI Length = 287 Score = 349 bits (895), Expect = 7e-95, Method: Composition-based stats. Identities = 131/276 (47%), Positives = 166/276 (60%), Gaps = 1/276 (0%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A+ IDGK IA Q+R+E+ +V + G+ P LAV+LVG +PAS +Y SK KA Sbjct: 1 MTAQYIDGKAIAAQLRAEIKAEVASLREQGIV-PKLAVILVGDDPASVVYARSKEKAAAN 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G + LP T+EA LL LI+ LNAD + GI+V+LPLP I KVLE IHP KDV Sbjct: 60 LGIAFELFTLPGDTTEAALLALIERLNADAAVHGIMVELPLPKQISKEKVLEAIHPLKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG HP N G L P L P TP + LL R ++ G V+IG VG+P+ LL Sbjct: 120 DGVHPLNRGYLMAGQPGLVPATPMSCMELLARSGVELAGKRVVIIGRGETVGKPLFFLLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T TV H TK+L V A+++I A GK G + G+ I A+VID GIN E+G + Sbjct: 180 RRNATVTVCHTRTKDLAAEVRRAEIVIAAAGKAGLVTGEMIAPDAVVIDAGINEGEDGNI 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 VGDV +AA+RAS I+PVPGGVG T A L N L Sbjct: 240 VGDVKTAEAAERASLISPVPGGVGACTTALLFRNVL 275 >UniRef50_P11586 Formyltetrahydrofolate synthetase n=378 Tax=root RepID=C1TC_HUMAN Length = 935 Score = 347 bits (891), Expect = 3e-94, Method: Composition-based stats. Identities = 122/294 (41%), Positives = 179/294 (60%), Gaps = 11/294 (3%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAG-LRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A+I++GK I+ Q+R+ + +V P LA++ VG+ S +Y+ K KA EE+ Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPA--GIDNVKVLERIHPDKD 119 G + LP TT+E+E+++ I +LN D+T+ G LVQLPL + I+ +V+ I P+KD Sbjct: 64 GIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKD 123 Query: 120 VDGFHPYNVGRLCQRA--PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSM 177 VDG N GRL + PCTP+G + L++ + G +AVV+G S IVG PM Sbjct: 124 VDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHD 183 Query: 178 ELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 LL T T H T +L V D+L+VA G+P + G+WIK GAIVID GIN + + Sbjct: 184 LLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYVPD 243 Query: 238 ------GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDP 285 KVVGDV +++A +RAS+ITPVPGGVGPMTVA L+++T+++ + + Sbjct: 244 DKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLEK 297 >UniRef50_Q12V26 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=cellular organisms RepID=FOLD_METBU Length = 286 Score = 346 bits (889), Expect = 4e-94, Method: Composition-based stats. Identities = 128/280 (45%), Positives = 183/280 (65%), Gaps = 1/280 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 KIIDG+ IA++V +EV V+ + PGL+ +LVG +PAS++YV K KAC V Sbjct: 6 NTKIIDGRAIAKKVEAEVKADVERLVREKGITPGLSAILVGEDPASKMYVRLKHKACGRV 65 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + LPE ++ ELLE I +LNA I GIL+QLPLP ++ + + I P KD D Sbjct: 66 GIFAEDQHLPEDITQEELLEAISSLNARKDIHGILLQLPLPKHLNEQEAMNAIDPAKDAD 125 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GFHP+N+G+L L PCTP+GI+ LE Y ++ G +AV++G SN+VG+PM+ L+ Sbjct: 126 GFHPFNMGQLLIGVEELVPCTPKGIIRALEEYGVEIQGKHAVIVGHSNVVGKPMAAMLVN 185 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 T ++ H FTK++ +AD+L+VA G I D +KEG+++ DVGI ENGKV Sbjct: 186 RNATVSICHVFTKDVTKFTRDADILVVATGVKHLIKEDMVKEGSVIFDVGITE-ENGKVY 244 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 GDV FE+ K+AS +TPVPGGVGP+T+ATL+++ L + + Sbjct: 245 GDVDFENVIKKASRVTPVPGGVGPVTIATLMQHVLMSAQK 284 >UniRef50_C2E8X3 Methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase n=1 Tax=Lactobacillus ruminis ATCC 25644 RepID=C2E8X3_9LACO Length = 284 Score = 346 bits (889), Expect = 5e-94, Method: Composition-based stats. Identities = 116/280 (41%), Positives = 180/280 (64%), Gaps = 1/280 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 +I++G+ ++ +V+ + + V+ P LAV+LVG + AS++YV +K +A E++ Sbjct: 1 MTEIMNGRDLSAKVKMNLKKSVEGLK-KVGVTPALAVILVGDDEASKVYVKNKHRAAEKI 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + +P + + +++++I+ N D + GILVQ+PLP ID +++ I P KDVD Sbjct: 60 GIKTIDETMPADSKQEDVIKMIEKYNNDPDVHGILVQMPLPKHIDEKAIIDAIDPKKDVD 119 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G HP N+GRL + PCTPRGI+ LL+ Y+ID G V++G SN+VGRP++ ++ Sbjct: 120 GSHPENMGRLFMNESQALPCTPRGIMELLKEYDIDVRGQEVVIVGRSNLVGRPLAALMIN 179 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 + T TV H T +L+ + AD+L+ AVGK D+IKEGA+VIDVGINR GK+ Sbjct: 180 SSATVTVAHSVTHDLQSVTKKADILVAAVGKAKMFTKDYIKEGAVVIDVGINRTAEGKLC 239 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 GDV +D +A+++TPVPGGVGPMTVA L++ T++ Sbjct: 240 GDVDAKDVMGKAAFLTPVPGGVGPMTVAMLMKQTVEFAER 279 >UniRef50_Q049N0 Methenyltetrahydrofolate cyclohydrolase n=18 Tax=Firmicutes RepID=FOLD_LACDB Length = 283 Score = 346 bits (887), Expect = 8e-94, Method: Composition-based stats. Identities = 122/283 (43%), Positives = 184/283 (65%), Gaps = 2/283 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 +I+DGK +A+++ ++ +V + +P L V+ +G +PAS++YVASK++ E++ Sbjct: 1 MGEILDGKKLARELGEKLGSEVDSLKE-HGVSPKLCVINIGDDPASKVYVASKKRKAEKL 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G Y LP SE ++L+LID+LNAD + ++VQLP+P I+ +V+ERI P+KDVD Sbjct: 60 GIKQVVYQLPADESEEDVLKLIDSLNADPEVSSLMVQLPVPPQINADRVIERIDPEKDVD 119 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 P N+GRL Q + P T GI+ LL+ Y ID G NAV++G SNIVG+P++ +L Sbjct: 120 CLTPANIGRLWQGKHFVEPATAAGIIALLDHYQIDLTGKNAVIVGRSNIVGKPLAALMLE 179 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 + ++ H ++NL + AD+L+ AVGK I D +KEGA+VIDVGINR+ +G +V Sbjct: 180 RNASVSILHSRSRNLADLTKQADILVCAVGKAEMIKADMVKEGAVVIDVGINRV-DGHLV 238 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 GDV F ++AS+ITPVPGGVGP+TV L+E ++ H Sbjct: 239 GDVDFAPVKEKASWITPVPGGVGPLTVEFLMEEVIKLTRRQHG 281 >UniRef50_Q6F9E6 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Acinetobacter sp. ADP1 RepID=FOLD1_ACIAD Length = 297 Score = 345 bits (886), Expect = 9e-94, Method: Composition-based stats. Identities = 149/286 (52%), Positives = 181/286 (63%), Gaps = 5/286 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 + KIIDGK IAQ V EV +V+ A P LAVVLVG +PASQ+YV +K + V Sbjct: 10 SPKIIDGKAIAQSVLEEVKLEVERYKAQ-GIEPCLAVVLVGEDPASQVYVRNKVQKAAFV 68 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S + SE ELL ID LN + + GILVQLPLP I+ +VLERIHP KDVD Sbjct: 69 GIRSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVD 128 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERY-NIDTFGLNAVVIGASNIVGRPMSMELL 180 GFH NVG L Q L PCTP G + LL+ D GL+AVVIG SNIVG+PM+ LL Sbjct: 129 GFHSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALLL 188 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL---EN 237 CT TV H T+N+ + AD+++ AVGK I ++K A+VIDVGINR+ E Sbjct: 189 KESCTVTVVHSKTRNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVGINRIMTHEK 248 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 ++VGDV FEDA S ITPVPGGVGPMT+A L++NTLQA H Sbjct: 249 TRLVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQAVRLQH 294 >UniRef50_B3ESU1 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Bacteria RepID=FOLD_AMOA5 Length = 298 Score = 345 bits (885), Expect = 1e-93, Method: Composition-based stats. Identities = 130/291 (44%), Positives = 174/291 (59%), Gaps = 10/291 (3%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A I+DGK +A +R +A++VQ G P LA+VLVG +PAS YV +K KAC+EV Sbjct: 1 MAVILDGKQVAHFLRQSLAEQVQTLAKEGKPIPHLAIVLVGDDPASHTYVYNKVKACQEV 60 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 GF + E+ LL LI LN D +I GI++QLPLP I+ +K+++ I P KDVD Sbjct: 61 GFQTTFIQEASHVQESTLLYLIHKLNEDTSIHGIIIQLPLPKHINAIKIIQAITPSKDVD 120 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G H +N GR+ P P TP GI+ LLE Y I+T G + V+IG VG P+S+ + Sbjct: 121 GLHTFNYGRMACNLPTHIPATPLGILLLLEHYQIETAGKHCVIIGRGPTVGAPLSILMSR 180 Query: 182 A----GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 T T+ H +T+ L + AD+L+VAVGKPG I D IK VIDVGI R+ + Sbjct: 181 NAYPGNATVTLCHSYTQQLTNFTRQADILVVAVGKPGLITADMIKPSTTVIDVGITRIPD 240 Query: 238 ------GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 ++ GDV FE+ A + ITPVPGGVGPMT+A L+ NTL+A Sbjct: 241 TTKKRGYRLKGDVAFEEVATLCNAITPVPGGVGPMTIAALLTNTLRAATNQ 291 >UniRef50_Q9X7F6 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Methylobacterium chloromethanicum CM4 RepID=FOLD_METC4 Length = 306 Score = 344 bits (882), Expect = 2e-93, Method: Composition-based stats. Identities = 137/283 (48%), Positives = 178/283 (62%), Gaps = 3/283 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A++IDG+ A ++ V + R PGLAVVL+G +PAS +YV +K + Sbjct: 1 MIAQVIDGRAEAARLTDNVRARAHRFTDEFGRCPGLAVVLIGDDPASSVYVKAKTEKARS 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 G +S S+ LP T+E LL LID LN D T+DGILVQLPLP I +VL+RI P KDV Sbjct: 61 TGILSSSHRLPSDTTEDALLRLIDQLNRDRTVDGILVQLPLPPHIAPERVLQRILPCKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP N G L P L PCTP G + L++ + G N VV+G S IVGRP + L Sbjct: 121 DGFHPVNAGLLATGQPGLVPCTPLGCLRLVQSVAAELVGQNVVVVGRSTIVGRPAAQVFL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE---N 237 A C+ T+ H+ ++++ H +AD+L+VA G PG + DW+K GA+VIDVGINR+ Sbjct: 181 NADCSVTILHKESRDVPGHCRSADILVVAAGSPGLVRRDWVKPGAVVIDVGINRIPVSSG 240 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 ++VGDV FE AS ITPVPGGVGPMTVA L+ENT+ Sbjct: 241 YRLVGDVDFEGVQYVASAITPVPGGVGPMTVAALMENTVACAE 283 >UniRef50_C7TD85 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase n=5 Tax=Bacteria RepID=C7TD85_LACRG Length = 283 Score = 344 bits (882), Expect = 3e-93, Method: Composition-based stats. Identities = 130/284 (45%), Positives = 179/284 (63%), Gaps = 1/284 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A +DG+ +++++ E+ Q V P LAVVLVGS+PAS++YV +K++ EE+ Sbjct: 1 MATRLDGRVVSKKILGELKQTVAKLAQQD-VTPTLAVVLVGSDPASEVYVRNKQRRAEEI 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S Y LPE TS+ LL + LN D +D ILVQLPLPAG+D V++ I P+KDVD Sbjct: 60 GVRSLMYRLPEDTSQMTLLAKVAELNQDPDVDAILVQLPLPAGLDERAVIDAIDPNKDVD 119 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GF P +VGRL P + TP GI+ LL+ Y+ID G V++G SNIVGRP++ ++ Sbjct: 120 GFSPVSVGRLWTNEPTVVASTPYGIMALLDAYDIDVAGQRVVIVGRSNIVGRPLAGLMVN 179 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 T T+ H T+NL+ AD+L+VAVG+P FI D +K GA VIDVGI+R +GK+ Sbjct: 180 HDATVTIAHSKTRNLKQLTREADILVVAVGRPHFIGADAVKPGATVIDVGISRGADGKLH 239 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDP 285 GDV + A A +TPVPGGVGPMT+A+L+ T+ Sbjct: 240 GDVDDDTVAPIAGALTPVPGGVGPMTIASLMAQTVALAKRRLHG 283 >UniRef50_UPI0001BC5140 bifunctional protein FolD n=3 Tax=Fusobacterium RepID=UPI0001BC5140 Length = 292 Score = 343 bits (880), Expect = 5e-93, Method: Composition-based stats. Identities = 123/281 (43%), Positives = 175/281 (62%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 K++DGK ++ +++ E+ K++ R PGL ++ +G N A+ +YV S+ K +G Sbjct: 2 KLLDGKKVSAEIKEELKSKIREEKERSGRVPGLGIIQIGHNEAASVYVQSQLKGSRALGM 61 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S Y ++ E +L+ I LN IDGI++QLPLP I + ++L+ I +KDVDGF Sbjct: 62 ESYLYSFDDSVEEETVLKKIKELNQTEEIDGIILQLPLPKHISHSRILQAIDVNKDVDGF 121 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 N+GRL PCTP G++ LL++Y+I+ N +IG SNIVG+PM + Sbjct: 122 KTENIGRLHLGEEGFNPCTPEGVIALLKKYDIEIASKNVTIIGRSNIVGKPMLGLFINHN 181 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T T+ + TKNL+ H E AD+++VAVGK F+ D ++EGAIVIDVGINR GK+VGD Sbjct: 182 ATVTICNSLTKNLKEHTERADIIVVAVGKEKFLTADMVREGAIVIDVGINRSREGKIVGD 241 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 V FE A +ASYITPVPGGVG MTVA L +N +A + Sbjct: 242 VDFEAVAPKASYITPVPGGVGSMTVAMLFQNIWKAFIRNRR 282 >UniRef50_Q17W13 Methenyltetrahydrofolate cyclohydrolase n=14 Tax=Helicobacter RepID=FOLD_HELAH Length = 292 Score = 341 bits (875), Expect = 2e-92, Method: Composition-based stats. Identities = 132/281 (46%), Positives = 184/281 (65%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 ++DG+ +A + ++ K+QA + P LAV+LVG +PAS YV K KACE VG Sbjct: 10 LLDGQALAYNIEEDLKYKIQAINTQTHKRPKLAVILVGKDPASITYVNMKIKACERVGMD 69 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 L E +EA+LL LI N + I G+LVQLPLP ID+ + E I P+KDVDGFH Sbjct: 70 FDLKTLQENITEAQLLSLIKDYNNNQNISGVLVQLPLPRHIDSKMISEAIDPNKDVDGFH 129 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 P N+G+LC + P TP G++ LLE Y+I G + +IGASNI+G+P+SM +L AG Sbjct: 130 PLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAIIGASNIIGKPLSMLMLNAGA 189 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 + +V H TK++ + +NAD++ V VGKP I +K+GA+V+D+GIN L +G++VGDV Sbjct: 190 SVSVCHILTKDINFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGDV 249 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDP 285 F +A K AS+ITPVP GVGPMT+ +L+ENTL A + Sbjct: 250 DFTNAQKVASFITPVPKGVGPMTIVSLLENTLIAFEKQQRK 290 >UniRef50_Q1II76 Methenyltetrahydrofolate cyclohydrolase n=15 Tax=Bacteria RepID=FOLD_ACIBL Length = 307 Score = 341 bits (875), Expect = 2e-92, Method: Composition-based stats. Identities = 137/307 (44%), Positives = 186/307 (60%), Gaps = 24/307 (7%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A I+DG I+ ++++EVA +V A PGLAVVLVG NPAS+IYV +K KACE Sbjct: 1 MLATILDGNKISAEIKTEVAAEVAELKAK-GLTPGLAVVLVGHNPASEIYVRNKVKACEM 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 G S + P+T S A+LL+L+++LN N IDGILVQLPLP +D+ K+L + P+KDV Sbjct: 60 TGIYSEQHTPPDTVSTADLLQLVESLNRRNDIDGILVQLPLPKQVDSKKILLAVSPEKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP NVG L P L PCTP G + +L R N+ G +AVV+G S+IVG+P++M L Sbjct: 120 DGFHPMNVGYLSTVRPGLVPCTPAGCMEILRRSNVPVEGADAVVVGRSDIVGKPIAMLLT 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN--- 237 A T T+ H T +L AD+L+ A+G+PG I D++K GA V+DVGIN++ + Sbjct: 180 NANATVTICHSKTHDLPAVCRRADILVAAIGRPGMITPDFVKPGATVLDVGINKITDRAE 239 Query: 238 -------------------GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 +VGD A+ A TPVPGGVGP+T+A L+ NT++A Sbjct: 240 FEKFFAGDAKREAAFAKNGSTLVGD-CHPKVAEVAGAFTPVPGGVGPLTIAMLMANTVKA 298 Query: 279 CVEYHDP 285 Sbjct: 299 AKLRRGN 305 >UniRef50_A0M554 Methenyltetrahydrofolate cyclohydrolase n=88 Tax=Bacteria RepID=FOLD_GRAFK Length = 299 Score = 340 bits (873), Expect = 3e-92, Method: Composition-based stats. Identities = 144/289 (49%), Positives = 190/289 (65%), Gaps = 10/289 (3%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+DGK I+ ++ E+A +V G + P LA ++VG + AS YV SK KACE VGF Sbjct: 3 ILDGKKISNDIKDEIAGEVTKIKKRGEKVPHLAAIIVGKDGASMTYVNSKVKACERVGFE 62 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S + LP T SE ELL+ I+ LN ++ IDG +VQLPLP I+ KVL + PDKDVDGFH Sbjct: 63 SSLFRLPHTVSELELLDKIEELNENDDIDGFIVQLPLPPQINTQKVLNAVDPDKDVDGFH 122 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 P N G++ P TP GI+ LLERY+I T G + VVIG S IVGRPMS+ + +G Sbjct: 123 PTNFGKMALDMTSFIPATPFGILELLERYDIPTKGKHTVVIGRSYIVGRPMSILMGRSGF 182 Query: 185 ----TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN--- 237 T T+TH FTKN+ AD++I+AVG P F+ G+ IK+ A++IDVGI R+ + Sbjct: 183 PGNSTVTLTHEFTKNITQVTSQADIIIIAVGIPDFLKGEMIKDDAVIIDVGITRVPDDHA 242 Query: 238 ---GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 + GDV FE+ +KRAS+ITPVPGGVGPMTV+ L++NTL A +H Sbjct: 243 ERGYVIKGDVDFENVSKRASFITPVPGGVGPMTVSMLLKNTLLARERHH 291 >UniRef50_Q11UD1 Methenyltetrahydrofolate cyclohydrolase n=6 Tax=Bacteria RepID=FOLD_CYTH3 Length = 290 Score = 340 bits (872), Expect = 4e-92, Method: Composition-based stats. Identities = 143/289 (49%), Positives = 192/289 (66%), Gaps = 10/289 (3%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +++DGK + Q++ E+ KV+A A G + P LA VLVG + A+ YV +K KACE VGF Sbjct: 2 QLLDGKITSDQIKEELKTKVEAIKAKGGKIPHLAAVLVGDSGAAVTYVNAKVKACELVGF 61 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S LPET +EA+LL + +NAD IDG +VQLPLP ID KV E I PDKDVDGF Sbjct: 62 KSTLVKLPETITEADLLAKVAEINADKDIDGYIVQLPLPKHIDEQKVTEAISPDKDVDGF 121 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA- 182 HP ++GR+ P P TP GI+ LLER I+T G + VV+G S+IVG PMS+ + Sbjct: 122 HPTSLGRMVLNLPTYLPATPYGIMQLLERNGIETSGKHCVVMGRSHIVGSPMSILMARNT 181 Query: 183 ---GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG- 238 T T+ H TKNL+ AD+LIVA+GKP F+ D +KEGA+V+DVGI+R+++ Sbjct: 182 NPGNATVTMVHSRTKNLKELTLQADILIVAIGKPEFVTADMVKEGAVVVDVGIHRIDDAT 241 Query: 239 -----KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 +++GDV F++ A + SYI+PVPGGVGPMT+A+L+ NTLQA Sbjct: 242 KKSGFRLLGDVKFDEVAPKTSYISPVPGGVGPMTIASLLMNTLQAAALK 290 >UniRef50_P13995 Methenyltetrahydrofolate cyclohydrolase n=52 Tax=cellular organisms RepID=MTDC_HUMAN Length = 350 Score = 339 bits (871), Expect = 5e-92, Method: Composition-based stats. Identities = 139/303 (45%), Positives = 188/303 (62%), Gaps = 17/303 (5%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A +I G+ +AQQ++ EV Q+V+ +A+G + P L+V+LVG NPAS YV +K +A V Sbjct: 36 EAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVV 95 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S + P + SE ELL LI+ LN D+ +DG+LVQLPLP ID ++ + PDKDVD Sbjct: 96 GINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVD 155 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GFH NVGR+C + P TP G+ +++R I T G N VV G S VG P++M L Sbjct: 156 GFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHT 215 Query: 182 AG--------CTTTVTHRFTK--NLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVG 231 G T T++HR+T L+ H AD++I A G P I D IKEGA VIDVG Sbjct: 216 DGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVG 275 Query: 232 INRLEN-----GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE--YHD 284 INR+ + K+VGDV FE ++A YITPVPGGVGPMTVA L++NT+ A + + Sbjct: 276 INRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLE 335 Query: 285 PQD 287 ++ Sbjct: 336 ERE 338 >UniRef50_C8PLX3 Bifunctional protein FolD n=1 Tax=Treponema vincentii ATCC 35580 RepID=C8PLX3_9SPIO Length = 304 Score = 339 bits (870), Expect = 7e-92, Method: Composition-based stats. Identities = 135/289 (46%), Positives = 184/289 (63%), Gaps = 7/289 (2%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A+IIDGK +A+Q+ V ++ A + P LA+V G++PASQ+Y+ +K KA E+ Sbjct: 1 MAQIIDGKRLAEQLTQAVTRENAAYCTRHPQ-PCLAIVSSGTDPASQVYIKTKIKALEKA 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G SR +T SE EL + TLNAD+T+DGIL+QLPLP +D+ ++L + P KD+D Sbjct: 60 GMRSRIIPYSQTISEEELTACVQTLNADDTVDGILIQLPLPYPLDSRRILAPLAPHKDID 119 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GF P N+GRL P PCTP+GI+ L Y I G +AV++G S IVG+P++ L Sbjct: 120 GFTPENLGRLLTGRPGFIPCTPQGILYALREYGIPLSGAHAVIVGRSAIVGKPLAALLTA 179 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN---- 237 A T T+ H TK+L AD+LI A G PG I G IK+GA VIDVGINR+ + Sbjct: 180 ADATVTLCHSKTKDLAAITRQADILIAAAGHPGLITGSMIKKGAAVIDVGINRIPDPSAP 239 Query: 238 --GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 ++ GDV FE AA++A +ITPVPGGVGP+TVA ++ NTL+A H Sbjct: 240 KGSRLTGDVDFESAAEQAGWITPVPGGVGPLTVAMVLRNTLRAAQLRHG 288 >UniRef50_Q8DMU0 Methenyltetrahydrofolate cyclohydrolase n=80 Tax=Bacteria RepID=FOLD_THEEB Length = 306 Score = 339 bits (869), Expect = 8e-92, Method: Composition-based stats. Identities = 141/290 (48%), Positives = 190/290 (65%), Gaps = 4/290 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 AA +DGK++AQ + ++A V+ A R+PGLAV+ VG++PAS +YV +K +AC V Sbjct: 5 AATCLDGKSLAQSIERQLADHVRTFQAQWGRSPGLAVLRVGNDPASAVYVRAKEQACSRV 64 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S LP T +EA LL I LN D +DGIL+QLPLP +D +L IHPDKDVD Sbjct: 65 GIQSFGAHLPATITEAALLAKITELNQDERVDGILLQLPLPPHLDPRPLLYAIHPDKDVD 124 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G HP N+GRL + P LR CTP G++ LL Y ID G +AVV+G S +VG+P+++ LL Sbjct: 125 GLHPENLGRLVRDEPGLRSCTPAGVMQLLAAYGIDVVGRSAVVVGRSILVGKPLALMLLS 184 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL--ENGK 239 A T T+ H ++ L +A++L+ A+G+P I D I+ GA+VIDVGINR+ +GK Sbjct: 185 ANATVTIAHSRSRELASITRSAEILVTAMGQPRRITADMIRPGAVVIDVGINRIQRPDGK 244 Query: 240 --VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQD 287 + GDV +E A ASYITPVPGGVGPMTVA L+ NT+ + H+ Q Sbjct: 245 SSLWGDVDYEAARAVASYITPVPGGVGPMTVAMLLHNTVWSYCRRHNWQQ 294 >UniRef50_Q8RAD0 Methenyltetrahydrofolate cyclohydrolase n=11 Tax=Thermoanaerobacterales RepID=FOLD_THETN Length = 280 Score = 338 bits (868), Expect = 1e-91, Method: Composition-based stats. Identities = 122/280 (43%), Positives = 176/280 (62%), Gaps = 6/280 (2%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M IIDGK I+ +++ EV +++Q P LA+++ G + +S++Y SK KACE Sbjct: 1 MKRMIIDGKEISNRIKEEVKREIQEF----GYKPRLAILMAGDDESSKVYANSKVKACES 56 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG ++ Y E E + + ++ LN D GI++++PLP G D KV + I+P KDV Sbjct: 57 VGIEAKVYYFSEK-EEDKFFDTLEKLNEDKDTHGIMIEMPLPKGFDVDKVYDTINPYKDV 115 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 D YN+GRL P PCTP+ I+ +LE +D G +AVVIG SNI+G+P++ LL Sbjct: 116 DCISNYNMGRLFAGKPLFVPCTPKAIIHILENTGVDLEGKHAVVIGRSNILGKPVAKLLL 175 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 CT TV H TK+L +H + AD+L+VA GK + GD +KEG ++ID GIN + GK+ Sbjct: 176 DKNCTVTVCHSKTKDLAYHTKQADVLVVAAGKMNLVRGDMVKEGVVLIDAGIN-VHEGKI 234 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 GD FE +ASY+TPVPGGVGP+T A +++NTL+A Sbjct: 235 YGDADFESIKDKASYVTPVPGGVGPVTTAMILKNTLEAFK 274 >UniRef50_B2S3X1 Methenyltetrahydrofolate cyclohydrolase n=35 Tax=cellular organisms RepID=FOLD_TREPS Length = 315 Score = 338 bits (867), Expect = 1e-91, Method: Composition-based stats. Identities = 129/288 (44%), Positives = 173/288 (60%), Gaps = 8/288 (2%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A++IDGK A + + +A +VQA AA AP LA VLVG +PAS YVA+K++A Sbjct: 1 MDARLIDGKQAAHECTARLATRVQALRAAVGTAPFLAAVLVGDDPASCTYVAAKQRALAR 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 ++ LP S A++LELI LN D + GIL+QLPLPA +D +V + P+KDV Sbjct: 61 AHLRGETHRLPAHASHAQVLELIARLNEDARVHGILIQLPLPAHLDAARVCRAVAPEKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP N G L P PCTP GIV LL R + G V++G S IVGRP+++ L Sbjct: 121 DGFHPLNCGALFLAQPGFVPCTPAGIVHLLRRAQVPLAGARVVIVGRSAIVGRPLAVLLA 180 Query: 181 LAG--CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN- 237 G T T+ H T+ L AD+L+ A+GK FI +++ GA+VIDVGI+ + + Sbjct: 181 SPGCDATVTLCHSHTRGLADICVQADILVAALGKARFIGAPFVRTGAVVIDVGIHHVPDA 240 Query: 238 -----GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 ++ GDV F+ A + ITPVPGGVGPMT+A L+ NTL A Sbjct: 241 TAPRGRRLCGDVDFDAVAHKVQAITPVPGGVGPMTIAMLLHNTLCAAE 288 >UniRef50_C5BI30 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=Bacteria RepID=FOLD_TERTT Length = 280 Score = 338 bits (867), Expect = 2e-91, Method: Composition-based stats. Identities = 121/283 (42%), Positives = 169/283 (59%), Gaps = 4/283 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M+A I+DGK +AQ+ +E++++V A + R P LA +LVG +PAS YV K AC Sbjct: 1 MSALILDGKALAQKTEAELSERVAALKSKTGRTPILATILVGGDPASATYVRMKGNACTR 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G S +LPETT+ ELL I LN + + GIL+Q P+P+ ID + I KDV Sbjct: 61 IGMDSMKVELPETTTTDELLAKIAELNNNPDVHGILLQHPVPSQIDERACFDAIDLSKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG GR+ TP+GI+ LLE Y I G +AVV+G S I+G+PM++ LL Sbjct: 121 DGVTCLGFGRMAMGEEAYGCATPKGIMRLLEAYEIPLEGKHAVVVGRSPILGKPMALMLL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 A T T+ H TK+L+ H+ AD+++ AVG P FI DWIK GA+V+D G + Sbjct: 181 NANATVTICHSRTKDLQSHIATADIVVGAVGIPEFIKADWIKPGAVVVDAGYHPGG---- 236 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 VGD+ A +AS +TPVPGGVGPMT+ TLI ++ + + Sbjct: 237 VGDIELGPLADKASALTPVPGGVGPMTINTLIYQSVDSGEKKL 279 >UniRef50_D0MY89 Bifunctional folD protein n=1 Tax=Phytophthora infestans T30-4 RepID=D0MY89_PHYIN Length = 307 Score = 337 bits (866), Expect = 2e-91, Method: Composition-based stats. Identities = 125/304 (41%), Positives = 182/304 (59%), Gaps = 16/304 (5%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 MAA++IDGK IA+ +R+ + V A A RAP L +++VG S +YV +K AC Sbjct: 1 MAARLIDGKAIAKALRAALKGDVAALTAKHGRAPALGLIMVGDRKDSALYVRNKNTACRR 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPA-GIDNVKVLERIHPDKD 119 G S ++ E S+ +++ ++ LN D +IDGILVQLPLP ++ ++++RI DKD Sbjct: 61 TGIRSENFLFDEGVSQDTIVQKVEELNEDPSIDGILVQLPLPGTQLNAQQIIDRIQHDKD 120 Query: 120 VDGFHPYNVGRLCQRA--PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSM 177 VDG HP+N G L R P L PCT +GI+ LL+ + G AV+IG SN+VG P+SM Sbjct: 121 VDGLHPFNAGELAMRGRYPYLIPCTAKGILALLDEQHTPLRGKTAVIIGRSNLVGNPVSM 180 Query: 178 ELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 L TT + H T +L +V AD+++ A G+P + G+W+K GA V+DVGIN + + Sbjct: 181 LLQKRDATTILCHSKTVDLPRYVRQADVVVAACGQPYLVRGEWLKPGATVVDVGINFVRD 240 Query: 238 -------------GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 K+VGDV F +A + A +TPVPGGVGPMT+A L+ N ++A D Sbjct: 241 VDGEFHGEANADGFKLVGDVNFHEACEVAGALTPVPGGVGPMTIAMLLHNVVEAFKRKMD 300 Query: 285 PQDE 288 + + Sbjct: 301 NRKK 304 >UniRef50_Q1QD30 Methenyltetrahydrofolate cyclohydrolase n=50 Tax=Bacteria RepID=FOLD_PSYCK Length = 298 Score = 336 bits (863), Expect = 4e-91, Method: Composition-based stats. Identities = 125/280 (44%), Positives = 173/280 (61%), Gaps = 1/280 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 +A ++DGK +A+Q+ ++ +V A A R P LA +LVG +PAS YV K AC+ V Sbjct: 13 SATVLDGKALAKQIEQQLRTRVDAIKAKTGRTPSLATILVGDDPASATYVRMKGNACKRV 72 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S ++P T+ AEL+ I LN+ + GIL+Q P+PA ID E+I KDVD Sbjct: 73 GMDSIRVEMPSVTTTAELMAKIYELNSSPDVHGILLQHPVPAHIDERACFEKIDLAKDVD 132 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G GR+ + CTP+GI+ LLE++NI+ GL AVV+G S I+G+PM+M LL Sbjct: 133 GVTCLGFGRMAMQQSAYGSCTPQGIMHLLEQHNIELAGLEAVVVGRSAILGKPMAMMLLN 192 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 A CT T+ H T++L H++ AD+++ AVG P I DWIK GA+VID G + +NG V Sbjct: 193 ANCTVTICHSRTQDLESHIKRADIIVGAVGVPELIKADWIKAGAVVIDAGFHPTDNGG-V 251 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 GD+ + AS TPVPGGVGPMT+ TLI T+ A + Sbjct: 252 GDIELQGVENIASAYTPVPGGVGPMTINTLIRQTVDAAEK 291 >UniRef50_A5VAA8 Methenyltetrahydrofolate cyclohydrolase n=107 Tax=cellular organisms RepID=FOLD3_SPHWW Length = 304 Score = 336 bits (863), Expect = 5e-91, Method: Composition-based stats. Identities = 154/285 (54%), Positives = 184/285 (64%), Gaps = 5/285 (1%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A+IIDGK A +R+ VA V A A RAPGLAVVLVG + ASQ+YV SK KA E G Sbjct: 9 AEIIDGKAYAAGLRARVATAVPAFRVAAGRAPGLAVVLVGEDAASQVYVRSKHKATVEAG 68 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 S + LP T SE ELL L++ LNAD+ +DGILVQLPLP ID KV+ I PDKDVDG Sbjct: 69 MESFEHRLPATASETELLALVERLNADDRVDGILVQLPLPPHIDEKKVIATIDPDKDVDG 128 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 FH N GRL PCTP G + LL+ D GL AVVIG SNIVG+PM+ LL Sbjct: 129 FHVVNAGRLAVGEAGYVPCTPLGCLMLLKDRRGDLSGLEAVVIGRSNIVGKPMAALLLAE 188 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE-----N 237 CT T+ H T++L V AD+++ AVG+P + GDWI+ GA VIDVGINR+ Sbjct: 189 NCTVTIAHSRTRDLAEVVRRADIVVAAVGRPEMVRGDWIRPGATVIDVGINRVPGAEPGK 248 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 ++VGDV F +AA A ITPVPGGVGPMT+A L+ NTL A Sbjct: 249 TRLVGDVAFAEAAAVAGAITPVPGGVGPMTIAVLLRNTLVAAHRR 293 >UniRef50_B8C1N0 5, 10-methylenetetrahydrofolate dehydrogenase n=1 Tax=Thalassiosira pseudonana RepID=B8C1N0_THAPS Length = 316 Score = 336 bits (862), Expect = 5e-91, Method: Composition-based stats. Identities = 130/316 (41%), Positives = 180/316 (56%), Gaps = 28/316 (8%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A+ IDGK+IA +RSE+A ++ + + PGLAV+LVGS SQ YV K+KAC + Sbjct: 1 MTAQDIDGKSIAATIRSELAAELSSLPSDSTSRPGLAVMLVGSRKDSQTYVRMKQKACSD 60 Query: 61 VGFVSRSYDLP--ETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDK 118 G VS + P E E LL+ I N D + GILVQLPLP I ++L+ + P K Sbjct: 61 CGMVSFLQEYPNGEEVEEEMLLKKIREWNEDEKVHGILVQLPLPEKISEERILKAVDPKK 120 Query: 119 DVDGFHPYNVGRLCQRA----------------PRLRPCTPRGIVTLLER----YNIDTF 158 DVDG HP N L + P PCTP+G + LL+R ++ Sbjct: 121 DVDGLHPANTASLFSTSTHAGAQKLNWKDFTSIPFHIPCTPQGCIELLDRINDGKGVEIE 180 Query: 159 GLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPG 218 G+NAVVIG SN+VG P++M LL T T+ H TKN+ + V+ AD+++ AVG+ +P Sbjct: 181 GMNAVVIGRSNLVGLPVAMLLLHRNATVTIVHSRTKNIENVVKQADIVVAAVGRANMVPA 240 Query: 219 DWIKEGAIVIDVGINRLENG------KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLI 272 W+K G VIDVGIN ++ ++VGDV + +A + +ITPVPGGVGP+T+A L+ Sbjct: 241 SWLKPGCTVIDVGINSVDAPDTKRGYRLVGDVNYAEAKEVCGWITPVPGGVGPLTIAMLL 300 Query: 273 ENTLQACVEYHDPQDE 288 NTL + E Sbjct: 301 RNTLNSWKRATGEGSE 316 >UniRef50_D0GMJ6 Bifunctional protein FolD n=2 Tax=Leptotrichia RepID=D0GMJ6_9FUSO Length = 283 Score = 336 bits (861), Expect = 7e-91, Method: Composition-based stats. Identities = 130/278 (46%), Positives = 190/278 (68%), Gaps = 2/278 (0%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 IDGK I+Q++ + ++ + R GLAV++ G+NPAS++YV +K KACE V F S Sbjct: 4 IDGKDISQKILKYIEKEHKLLRDKYERTAGLAVIMAGNNPASEVYVKNKIKACESVKFYS 63 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 L E +EA+ ++ I+ N ++ IDGIL+QLPLP I+ +KV+ + P+KDVDGFH Sbjct: 64 EIVRLDENVTEADFIKEIERFNKNDKIDGILIQLPLPEHINELKVINAVSPEKDVDGFHV 123 Query: 126 YNVGRLCQRAP-RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 N+G++ PCTP GI+ LLE Y+ID G + V++G SNIVG+P+++ L+ Sbjct: 124 VNIGKMMTGDKSGFWPCTPYGIIQLLEEYDIDPAGKDVVIVGRSNIVGKPLALMLIEKSA 183 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T V + TKN+R ++NAD++I A G P I + IKEGA+VIDVGINR+ NGK+ GDV Sbjct: 184 TVQVCNTKTKNIREKLKNADIVIAAAGVPNLISAEDIKEGAVVIDVGINRV-NGKLCGDV 242 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 +E+ +++A YITPVPGGVGPMT+A+LI+NT ++ + Sbjct: 243 NYEEVSEKAGYITPVPGGVGPMTIASLIKNTFKSYINK 280 >UniRef50_B1ZYH0 Methenyltetrahydrofolate cyclohydrolase n=8 Tax=root RepID=FOLD_OPITP Length = 293 Score = 334 bits (858), Expect = 2e-90, Method: Composition-based stats. Identities = 124/291 (42%), Positives = 172/291 (59%), Gaps = 14/291 (4%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 +IDG IA + +E+ +V A R P +A+V +G +PAS YV +K + E+G Sbjct: 3 LIDGSKIAATIVAELKAEVAALT---GRKPCIALVRIGEDPASVSYVKNKERTAAEIGLT 59 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 R P T S+AEL LID LNAD +DGILVQ P+P +D ++V RI P+KDVDG Sbjct: 60 GRVILPPVTISQAELFALIDGLNADAGVDGILVQAPMPKHLDELQVFRRIAPEKDVDGLG 119 Query: 125 PYNVGRLCQRAP-RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 N+G++ Q CTP GI+ LL R +D G + VV+G S +VG+P+++ L Sbjct: 120 TMNLGKVAQDDDTGFVSCTPAGIMELLSRSGVDLKGKHVVVVGRSLLVGKPVALLALQKK 179 Query: 184 C----TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG- 238 T T+ H TK+L AD+LI A+G+ GF+ D +K G +VIDVGINR+ + Sbjct: 180 AGANGTVTICHSATKDLPAITRQADVLIAAIGRAGFVTADMVKPGVVVIDVGINRVPDST 239 Query: 239 -----KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 ++VGDV F + AS ITPVPGGVGPMTVA L++NT++A Sbjct: 240 KKSGYRLVGDVDFPAVSPLASQITPVPGGVGPMTVAMLMKNTVKAYRLRQH 290 >UniRef50_A5V1H2 Methenyltetrahydrofolate cyclohydrolase n=7 Tax=Bacteria RepID=FOLD_ROSS1 Length = 288 Score = 333 bits (855), Expect = 3e-90, Method: Composition-based stats. Identities = 131/286 (45%), Positives = 176/286 (61%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A I+DG+ +A+ +R E+ QA I AP LAVV + +PAS Y + RK CEE Sbjct: 1 MTAIILDGRALAKTLREELRADTQAFIQNNGIAPSLAVVKIAGDPASDRYTRTIRKGCEE 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G + LP T++A L E I L+ D TI GIL+ LPLP G+D+ + + +I P KDV Sbjct: 61 IGITFTDHTLPPETTQAMLEETISALSFDRTIHGILLHLPLPPGLDSARAIAQIDPAKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG HPYN G L P L P TP G + LL R NI G +A V+G S +VG+PM++ LL Sbjct: 121 DGVHPYNAGLLAMGRPGLIPNTPAGGMELLLRNNIPLKGQHATVVGRSVVVGKPMALLLL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T T+ H TK+L V +AD+++ A GKPG I GD +K GA+V+D G+N LE+G+V Sbjct: 181 NEHATVTIAHSRTKDLAAVVRSADIVVAATGKPGLITGDMVKPGAVVVDFGVNVLEDGRV 240 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 VGDV F+ AS ITPVPGG GP+T L+ N L+A + + Sbjct: 241 VGDVDFDSVVNVASAITPVPGGTGPVTNVMLLRNVLRAAQQQLASR 286 >UniRef50_UPI00015B59A5 PREDICTED: similar to ENSANGP00000016878 n=2 Tax=Eumetazoa RepID=UPI00015B59A5 Length = 866 Score = 333 bits (854), Expect = 4e-90, Method: Composition-based stats. Identities = 118/289 (40%), Positives = 170/289 (58%), Gaps = 10/289 (3%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAG-LRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 ++ G +A+++R +A+ V A APGLA+V VG S +Y+ K KA E+ Sbjct: 7 GVVLSGTDLAKEIRESLAKDVAAIQQKLPNYAPGLAIVQVGGREDSNVYIRMKIKAASEI 66 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPA--GIDNVKVLERIHPDKD 119 G + +P TT+E ELL ++ LN D GI+VQ+PL + I++ + + + PDKD Sbjct: 67 GIKATHVKMPNTTTEHELLTKLNKLNNDPDTHGIIVQMPLDSVNKINSHLITDTVSPDKD 126 Query: 120 VDGFHPYNVGRLCQRA-PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSME 178 VDG + N GR+ PCTP G + L++R + G AVV+G S IVG P++ Sbjct: 127 VDGLNTINEGRVAIGDMSGFLPCTPNGCIELIKRSGVPIAGAQAVVLGRSKIVGTPVAEL 186 Query: 179 LLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 L T TV H TK+L V AD+++V +G+P + G WIK GA+VID GIN + + Sbjct: 187 LKWHNATVTVCHSRTKDLPSVVSKADIVVVGIGQPELVKGSWIKPGAVVIDCGINSIPDP 246 Query: 239 ------KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 ++VGDV + +AAK ASYITPVPGGVGPMTVA L++NT+ + Sbjct: 247 TKKSGQRLVGDVDYAEAAKVASYITPVPGGVGPMTVAMLMKNTVISAQR 295 >UniRef50_C8P9U1 Putative uncharacterized protein folD2 n=1 Tax=Lactobacillus antri DSM 16041 RepID=C8P9U1_9LACO Length = 289 Score = 332 bits (851), Expect = 1e-89, Method: Composition-based stats. Identities = 124/282 (43%), Positives = 173/282 (61%), Gaps = 3/282 (1%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 IIDGK IA+++ ++ Q+V A A PG+AV++VG +PASQIY +K + +++G Sbjct: 2 IIDGKKIAREINAKTRQQVAALKAHQ-LTPGIAVIVVGDDPASQIYTRTKHRLAQKLGIA 60 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S Y P +A +L+ + LN D+++D ILVQ PLPA ++ +++ I P KD DG H Sbjct: 61 STRYHFPADVDQATVLQQVRKLNRDDSVDAILVQAPLPAQLNGEEIVNAIDPAKDADGLH 120 Query: 125 PYNVGRLCQRAPRLRP--CTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 P N+GRL + P CTPRGI+TLL++Y + G N V++G S +VG+P+ L Sbjct: 121 PLNLGRLYAKQGGHYPVACTPRGIMTLLKQYQVPLAGANVVIVGRSLLVGKPLLALLNNQ 180 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T T R TK AD+LIVA G PG + +K GA+VIDVGINRL +GK+VG Sbjct: 181 NATVTFVGRHTKKRATLTRQADILIVAAGVPGLVKAGDVKAGAVVIDVGINRLPSGKLVG 240 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 DV F A A ITPVPGGVGP+TVA L+ T++ + Sbjct: 241 DVDFAGVASLARLITPVPGGVGPLTVAMLMRQTVELAEWRRE 282 >UniRef50_C1XHV3 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); methenyltetrahydrofolate cyclohydrolase n=2 Tax=Bacteria RepID=C1XHV3_MEIRU Length = 293 Score = 330 bits (847), Expect = 3e-89, Method: Composition-based stats. Identities = 119/284 (41%), Positives = 163/284 (57%), Gaps = 10/284 (3%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 + G +A+ V E+ Q +A P L VV +G +PAS YV K + + +G S Sbjct: 4 LSGPPVAEAVYQEL----QTLLATLPYVPHLRVVRLGDDPASVAYVRLKDRQAKRLGLSS 59 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 + PE+TS+ ELL I LNAD +DGILVQ P+P +D VLE I P KDVDG P Sbjct: 60 QVDVFPESTSQEELLAHIARLNADPEVDGILVQSPVPRQVDFNAVLEAIDPLKDVDGLTP 119 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCT 185 N GR+ L CTP G++ LL+ Y I G V++G SN+VG+P++ +L T Sbjct: 120 VNAGRMWMGLEALESCTPAGVMRLLKHYQIPLAGKEVVIVGRSNLVGKPLAALMLREHAT 179 Query: 186 TTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGK-----V 240 T+ H T++L AD+L+ AVGK G I + ++ GA+V+DVGINR+ + + Sbjct: 180 VTLAHSRTQDLAAVCRRADVLVAAVGKAGLITPEMVRPGAVVVDVGINRVGQNEKGRDIL 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 VGDV A AS +TPVPGGVGPMTVA L+ NT+ A + Sbjct: 240 VGDVA-PGVAAVASALTPVPGGVGPMTVAMLLYNTVIAAMRRRG 282 >UniRef50_A9A4N5 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=Thaumarchaeota RepID=FOLD_NITMS Length = 287 Score = 330 bits (846), Expect = 3e-89, Method: Composition-based stats. Identities = 129/281 (45%), Positives = 173/281 (61%), Gaps = 4/281 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M IDGK I+Q V+ V + V+ P LA VLVG NPAS YV +K +ACEE Sbjct: 1 MTGTKIDGKVISQSVKDRVKKAVEELKNQ-GINPCLATVLVGDNPASATYVRNKHRACEE 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG ++ + L +T++A+L E+I+ LN DN++ GILVQLPLP +D RI P KDV Sbjct: 60 VGITTKDHKLDASTTQAQLNEIIENLNNDNSVHGILVQLPLPEQLDEFTTTSRISPLKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG P+N G L + L CTP G++ + + + I+ G N V+I SN+VG+P+ LL Sbjct: 120 DGLTPHNAGLLAMKKAALVACTPSGVMEMFDYHGIELEGKNIVLINRSNLVGKPLYHLLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFI--PGDWIKEGAIVIDVGINRLENG 238 T H TKNL ++AD++I AVG D IKEGAIVIDV I+R + Sbjct: 180 DKNATVITCHSRTKNLVELCQSADIIITAVGDRNKFTLTSDMIKEGAIVIDVAISRFQE- 238 Query: 239 KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 K+VGD +ED ++AS+ TPVPGGVGPMTVA L++NT+ A Sbjct: 239 KLVGDADYEDIIQKASFATPVPGGVGPMTVAMLLKNTITAA 279 >UniRef50_C8P269 Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase n=1 Tax=Erysipelothrix rhusiopathiae ATCC 19414 RepID=C8P269_ERYRH Length = 284 Score = 330 bits (846), Expect = 4e-89, Method: Composition-based stats. Identities = 131/281 (46%), Positives = 180/281 (64%), Gaps = 2/281 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 I+DG +++ +R+ + + + I G RAP L VV+VG +PASQ YV SK K C+ V Sbjct: 1 MTTILDGLAVSKAIRASLKDETEVLIKQGKRAPSLTVVIVGDDPASQTYVNSKVKQCKSV 60 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 GF S++ T++ LL++I TLN DN +DGILVQLPLP ID ++E I P KDVD Sbjct: 61 GFSSQAISCEVDTTQEALLKIIRTLNHDNDVDGILVQLPLPKHIDENVIIEAIDPQKDVD 120 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G HP NVG L P CTP+GIV LL+ YN++ G A+VIG S +VG+P+S L Sbjct: 121 GLHPLNVGYLELNRPGFVSCTPKGIVRLLDWYNVELEGKRALVIGRSRLVGKPVSTLLSQ 180 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 T T+ H TKNL V + D+++VA+GKP IP WI + +++DVGI+R+ +G + Sbjct: 181 KNATVTLAHSKTKNLEELVRSNDIIVVAMGKPEAIPASWISDQHVLVDVGIHRI-DGNLR 239 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 GDV A + A+Y TPVP GVGPMT+A+L+ENT+ A Sbjct: 240 GDVDRR-AYEIAAYATPVPKGVGPMTIASLLENTMIAYKLK 279 >UniRef50_B1GZ24 Bifunctional protein FolD n=2 Tax=Bacteria RepID=B1GZ24_UNCTG Length = 296 Score = 329 bits (845), Expect = 5e-89, Method: Composition-based stats. Identities = 130/289 (44%), Positives = 176/289 (60%), Gaps = 9/289 (3%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 K+IDGK I+ R+E+ ++V + PGLA VLVG +PAS++Y+ SK KACE+ G Sbjct: 2 KLIDGKKISSDKRAEIKEEVAKIKQQTEKIPGLATVLVGGDPASRVYIKSKIKACEDAGI 61 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S ++L +S+ E++ LI LN ++ IDGIL+QLPLP D + L + P KDVDG Sbjct: 62 KSFHHNLDANSSKEEIIALIKKLNENSEIDGILLQLPLPQNKDAQECLNAVSPLKDVDGL 121 Query: 124 HPYNVGRL--------CQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPM 175 HP+N G L L CTP G+V +L + I G AVVIG SN+VG+P+ Sbjct: 122 HPFNAGLLNLSKSWNEIIEKNILVSCTPLGVVHILHKSGIIIEGKTAVVIGRSNLVGKPL 181 Query: 176 SMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL 235 SM LL T + H T+NL+ ++AD+++ AVGK F+ D+IK GA+VIDVGINR Sbjct: 182 SMLLLANNATVIMAHSKTRNLKEICKSADIVVAAVGKSKFVNKDFIKTGAVVIDVGINRT 241 Query: 236 ENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 G + GDV F+ ITPVPGGVGPMT+ L+ENTL+A Sbjct: 242 SEG-LCGDVDFDAVKDMDIKITPVPGGVGPMTITMLLENTLKAFNNRKR 289 >UniRef50_Q18GK1 Methenyltetrahydrofolate cyclohydrolase n=15 Tax=cellular organisms RepID=FOLD_HALWD Length = 311 Score = 329 bits (844), Expect = 6e-89, Method: Composition-based stats. Identities = 140/282 (49%), Positives = 177/282 (62%), Gaps = 8/282 (2%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 ++IDG +A +RS++ V + P LA VL+ +PASQ YV+ K CEEVG Sbjct: 19 QLIDGTEVAASIRSDLISSVTRIV-NTGTTPQLATVLMNDDPASQTYVSMKHDDCEEVGI 77 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 +R + AEL + +D LNAD+++ GILVQ+PLP +D +VL RI P KDVDGF Sbjct: 78 ATRDITIDPEAPAAELFDTVDELNADSSVHGILVQMPLPDHVDEREVLRRIDPKKDVDGF 137 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA- 182 HP NVGRL PR +PCTP GI LL +I+T G NAVVIG SNIVG+PM+ L+ Sbjct: 138 HPENVGRLVAGQPRYKPCTPHGIQKLLIAADIETEGANAVVIGRSNIVGKPMANLLIQKA 197 Query: 183 ---GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN-- 237 T T H T NL +AD++I A G P I GD I G +VIDVGINR+E Sbjct: 198 DAGNATVTTCHSRTNNLASKTRDADIIIAAAGVPEMIDGDMISTGTVVIDVGINRVETEN 257 Query: 238 -GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 ++VGDV FE AAK+A ITPVPGGVGPMT A L+ NT++A Sbjct: 258 GSELVGDVEFESAAKKADAITPVPGGVGPMTRAMLLWNTVKA 299 >UniRef50_Q2GLF2 Methenyltetrahydrofolate cyclohydrolase n=41 Tax=Bacteria RepID=FOLD_ANAPZ Length = 304 Score = 329 bits (843), Expect = 9e-89, Method: Composition-based stats. Identities = 116/288 (40%), Positives = 171/288 (59%), Gaps = 4/288 (1%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 IIDGK A + + ++ P L V++VG +PAS++YV +K++ EE+G Sbjct: 7 NIIDGKAAAADLLGRLKVVMEGLKEEHGLFPSLVVIIVGDDPASRLYVGNKQRKAEELGI 66 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S++ LP T++ ELL +I LN D + GILVQLPLP ID + ++ I P+KDVDGF Sbjct: 67 NSKTIALPYETTQEELLGIIQELNEDENVHGILVQLPLPKHIDKILIINAIDPEKDVDGF 126 Query: 124 HPYNVGRLCQRA-PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 H N G+L + PCTP+G + L+++ AVVIG SNIVG+P+++ L+ Sbjct: 127 HNANAGKLLTGEMDCMVPCTPQGCIYLIKKVMPVLSSKRAVVIGRSNIVGKPVALLLMYE 186 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN---GK 239 CT ++ H T N+ H +A+++I AVGK + +W+ GA+VIDVGIN + + + Sbjct: 187 NCTVSILHSATANIEEHCRDAEIIIAAVGKARMVKSEWVSPGAVVIDVGINLITSESKNR 246 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQD 287 VGDV FE + + ITPVPGGVGPMT+A L+ NT+ + Sbjct: 247 FVGDVDFESVRDKVAAITPVPGGVGPMTIAFLLVNTVLGACRQKGIKQ 294 >UniRef50_D0J906 Putative methenyltetrahydrofolate cyclohydrolase n=1 Tax=Blattabacterium sp. (Periplaneta americana) str. BPLAN RepID=D0J906_BLASP Length = 292 Score = 327 bits (839), Expect = 2e-88, Method: Composition-based stats. Identities = 126/288 (43%), Positives = 182/288 (63%), Gaps = 8/288 (2%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQA-RIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 ++++G +A +R E++++++ R P L ++L+G+N +S YV SK + C+ Sbjct: 1 MTQLLNGNKLAIDIRKEISKEIEKSIRNKKKRLPHLGIILLGTNSSSLTYVNSKIQECKN 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G S LP +SE ELL+ I +N + IDG +VQLPL I++ K++ I+P KDV Sbjct: 61 IGIKSSLIHLPNDSSEKELLKEIQKMNNNPLIDGFIVQLPLQKHINSDKIIMSINPRKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP N G++ P T GI+T+LERY I+ G + VVIG S IVGRP+S+ + Sbjct: 121 DGFHPENFGKMSLDMKAFFPATALGILTILERYKIEISGKHTVVIGRSRIVGRPISILMS 180 Query: 181 LAGC----TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE 236 T T+TH T N+ ++ + AD++I AVG+PGF+ G IKEGAIVIDVGI +++ Sbjct: 181 RKNYLGNSTVTLTHSQTPNIDYYTKQADIIITAVGRPGFLTGKMIKEGAIVIDVGITKVK 240 Query: 237 NGK---VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 NGK + GDV F +ASY+TPVPGGVGPMT LI+NTL A + Sbjct: 241 NGKKSFLKGDVDFNSVYGKASYLTPVPGGVGPMTRIMLIKNTLIAALN 288 >UniRef50_A9HEL1 Methenyltetrahydrofolate cyclohydrolase n=82 Tax=cellular organisms RepID=FOLD_GLUDA Length = 311 Score = 327 bits (838), Expect = 4e-88, Method: Composition-based stats. Identities = 146/284 (51%), Positives = 179/284 (63%), Gaps = 4/284 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A++IDGK A + +A+ VQ+ PGLAVVLVG++PAS++YV +K Sbjct: 20 TARLIDGKAFAANLTQTIARDVQSFHDRYRVTPGLAVVLVGNDPASEVYVRNKALQTHRA 79 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S + LP TTS+AELL LI LNAD I GILVQLPLPAG+D V V I PDKDVD Sbjct: 80 GMRSFMHMLPATTSQAELLALIGRLNADPEIHGILVQLPLPAGLDPVAVTNAILPDKDVD 139 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G N GRL P + PCTP G + LL+ D GL+AV+IGASN+VGRPM+ LL Sbjct: 140 GLGEVNAGRLALGQPGIVPCTPLGCLMLLKSELGDLRGLHAVIIGASNLVGRPMARLLLA 199 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE----N 237 GCT TV H T++ D+L+VA G G + GDWIK GA VIDVGI R+ Sbjct: 200 EGCTVTVGHIDTRDPAALARQGDILVVATGCHGLVRGDWIKPGAAVIDVGITRISLPSGK 259 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 ++VGDV F++A RA ITPVPGGVGPMT+A L+ NTL A Sbjct: 260 TRLVGDVAFDEAVTRAGCITPVPGGVGPMTIACLLNNTLAAARR 303 >UniRef50_B0S8U6 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=Bacteria RepID=FOLD_LEPBA Length = 291 Score = 326 bits (835), Expect = 8e-88, Method: Composition-based stats. Identities = 121/287 (42%), Positives = 177/287 (61%), Gaps = 4/287 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 ++ ++DGK I++++R+ + + + A G P LA +LVG+NPAS+ YV K KACE+V Sbjct: 3 SSILLDGKAISEKIRNRIQETLAKAKAEGKGIPTLATILVGNNPASETYVNMKVKACEKV 62 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G SR L E T+ ELL I LN D +I+GIL+Q P+P ID K + I +KDVD Sbjct: 63 GMHSRYIRLKEETTTEELLGEIRKLNLDPSINGILLQHPVPHQIDERKAFDEIALEKDVD 122 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G + G+L + PCTP G+V LL+ Y ID G +AVV+G S I+G+PM++ L Sbjct: 123 GVTTISFGKLSMNSEAYYPCTPYGMVLLLQEYGIDVTGKHAVVVGRSPILGKPMAIMLTN 182 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 T T+ H T++L V+ AD+++ AVGKP FI +W+KEG +++D G N V Sbjct: 183 LNATVTLCHSKTEDLPSLVKQADIIVGAVGKPEFIKAEWMKEGVVILDAGYNVGN----V 238 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQDE 288 GD+ A ++SY TPVPGGVGPMT++ L+ T+ + + P+ E Sbjct: 239 GDIEVSKAKDKSSYYTPVPGGVGPMTISVLLLQTMYSFLGQFSPKLE 285 >UniRef50_UPI0000DB7ABF PREDICTED: similar to Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor n=1 Tax=Apis mellifera RepID=UPI0000DB7ABF Length = 407 Score = 325 bits (834), Expect = 9e-88, Method: Composition-based stats. Identities = 129/299 (43%), Positives = 178/299 (59%), Gaps = 13/299 (4%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A IIDGK IA ++++E+ V I + P L + VG+NPAS+IYV K KA + Sbjct: 109 NAIIIDGKKIANKIQNELKITVDNWINDNKKRPKLVAIKVGNNPASKIYVEKKIKAANFI 168 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + + L E +S+ +++ ID LN D T+DGILVQLPL ++ +V + I P KDVD Sbjct: 169 GIENYTIHLDEKSSQQDIINEIDNLNKDKTVDGILVQLPLIKHMNEQEVCQAIIPSKDVD 228 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GFH N+G L + P T + L+ R NI+TFG NAVV+G S VG P+++ L Sbjct: 229 GFHLENLGNLALNRNGIIPATALAVKELIIRNNIETFGKNAVVVGRSKHVGLPIALLLHG 288 Query: 182 A--------GCTTTVTHRFTKN--LRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVG 231 TTT+ HR T + L + ADL++VA G PG I + IK GA +IDVG Sbjct: 289 DSKDRTGALDMTTTICHRHTPHTELEKFTKLADLVVVAAGIPGLITKEMIKPGACIIDVG 348 Query: 232 INRLE---NGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQD 287 I R++ K+VGDV FE+ A YITPVPGGVGPMTVA L++NT+ A + ++ + Sbjct: 349 ITRIKMDNKYKIVGDVDFENVKSIAGYITPVPGGVGPMTVAMLMKNTILAANKNYENSN 407 >UniRef50_D0N1V3 Bifunctional folD protein n=1 Tax=Phytophthora infestans T30-4 RepID=D0N1V3_PHYIN Length = 308 Score = 325 bits (833), Expect = 1e-87, Method: Composition-based stats. Identities = 128/302 (42%), Positives = 173/302 (57%), Gaps = 19/302 (6%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 + ++DGK + + +++ + R+ GLAV++VGS S YV K+KAC V Sbjct: 6 SPILLDGKATSDAICTQLQPQCVDFKQRYGRSVGLAVMVVGSRKDSATYVRMKQKACTAV 65 Query: 62 GFVSRSY-----DLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHP 116 G S D P+ + +ELL +I LN +DGI+VQLPLP+ D +L I P Sbjct: 66 GITSWKIAIALDDKPQESVTSELLAIIKQLNNREDVDGIIVQLPLPSFCDESAILATIAP 125 Query: 117 DKDVDGFHPYNVGRLCQRA-------PRL-RPCTPRGIVTLLERYNIDTFGLNAVVIGAS 168 +KDVDG HP + +L Q A P PCTP G + LL+ Y I G + VV+G S Sbjct: 126 NKDVDGLHPESHAKLFQYATTKAQLVPSFALPCTPAGCLELLDHYKIPLEGKHVVVMGRS 185 Query: 169 NIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVI 228 IVG P+S+ L T T+ H T++L+ V AD++I A+G+P F+ GDWIK GA VI Sbjct: 186 QIVGLPVSLLCLHRNATVTMCHSHTRDLKARVLEADIVIAAIGRPCFVQGDWIKPGATVI 245 Query: 229 DVGINRLEN------GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 DVGIN LE+ ++VGDV F A K ITPVPGGVGPMTVA L++NTLQ + Sbjct: 246 DVGINPLEDATKKSGYRLVGDVDFNAAVKVVHAITPVPGGVGPMTVAMLLKNTLQCAIRR 305 Query: 283 HD 284 Sbjct: 306 AQ 307 >UniRef50_D1AX33 Methylenetetrahydrofolate dehydrogenase (NADP(+)) n=1 Tax=Streptobacillus moniliformis DSM 12112 RepID=D1AX33_STRM9 Length = 285 Score = 325 bits (833), Expect = 1e-87, Method: Composition-based stats. Identities = 123/282 (43%), Positives = 180/282 (63%), Gaps = 3/282 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M ++DG+ ++ + ++ + Q I + GLA + VG++ AS IY+ +K K C+E Sbjct: 1 MIKSMLDGRYVSNILYEKLKIEYQILIDKIGKRAGLAFIKVGNDRASTIYLKNKAKKCDE 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G ++ E +E EL+ I+ LN D IDGIL+QLPLP+ I+ + V+ I+P KDV Sbjct: 61 LGIYQKTIIFEENITETELISEINKLNDDKNIDGILLQLPLPSHINYISVMSTINPKKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHP NVG L + + CTP+GI+ LL YNI + V+IG SNIVG+P+++ L+ Sbjct: 121 DGFHPENVGNLLFKDKGIYSCTPQGIMELLNYYNISIESKDIVIIGRSNIVGKPLALMLI 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 G T V + TK+L + + AD+LI A G I ++IK+GA+VIDVGI+ E GK+ Sbjct: 181 NEGATVQVCNSKTKDLFNKTKQADILISATGVSHLIKSEYIKDGAVVIDVGISEFE-GKI 239 Query: 241 VGDVVFEDAAK--RASYITPVPGGVGPMTVATLIENTLQACV 280 +GDV FED + YITPVPGGVGPMT+ +LI+NT++A Sbjct: 240 IGDVDFEDVIQNSNVRYITPVPGGVGPMTIYSLIKNTIRAFE 281 >UniRef50_A8GNK0 Methenyltetrahydrofolate cyclohydrolase n=15 Tax=cellular organisms RepID=FOLD_RICAH Length = 295 Score = 325 bits (833), Expect = 1e-87, Method: Composition-based stats. Identities = 119/286 (41%), Positives = 171/286 (59%), Gaps = 7/286 (2%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 IIDGK +A ++ ++ ++Q + +P LA+VLVG NPAS IYV +K K ++ Sbjct: 1 MNNIIDGKALANEILEDLKLEIQELKSQTNASPKLAIVLVGDNPASIIYVKNKIKNAHKI 60 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + +L T +L+ I+ LN DN I G++VQLPLP ID K+L + P KDVD Sbjct: 61 GIDTLLVNLSTTIHTNDLITKINELNHDNEISGMIVQLPLPNSIDKNKILSAVSPYKDVD 120 Query: 122 GFHPYNVGRLCQR-------APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRP 174 GFHP NVG L + PCT G + ++++Y + G + VVIG SNIVG+P Sbjct: 121 GFHPLNVGYLHSGIIDVSEFSQSFIPCTALGCLAVIKKYEPNLSGKHVVVIGRSNIVGKP 180 Query: 175 MSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINR 234 +S LL C+ T+ H T NL AD+++ A+G P + ++ +IVIDVGINR Sbjct: 181 LSALLLKEDCSVTICHSKTHNLGSIALKADIVVAAIGSPLKLTAEYFNPESIVIDVGINR 240 Query: 235 LENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 + K++GDV FE + YITPVPGG+GPMT+A L++NT++A Sbjct: 241 ISGNKIIGDVDFEHVKSKVKYITPVPGGIGPMTIAFLLKNTVKAFK 286 >UniRef50_Q9H903 Methenyltetrahydrofolate cyclohydrolase n=75 Tax=cellular organisms RepID=MTD2L_HUMAN Length = 289 Score = 324 bits (832), Expect = 2e-87, Method: Composition-based stats. Identities = 128/285 (44%), Positives = 172/285 (60%), Gaps = 15/285 (5%) Query: 12 AQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLP 71 A+ ++ E+ + V++ ++ G R P L+++LVG NPAS YV +K +A VG S P Sbjct: 2 AKHIQKEIQRGVESWVSLGNRRPHLSIILVGDNPASHTYVRNKIRAASAVGICSELILKP 61 Query: 72 ETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRL 131 + S+ ELL++ D LN D + GILVQLPLP +D + I P+KDVDGFH N+GRL Sbjct: 62 KDVSQEELLDVTDQLNMDPRVSGILVQLPLPDHVDERTICNGIAPEKDVDGFHIINIGRL 121 Query: 132 CQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG-------- 183 C L P T + +++R I TFG N VV G S VG P++M L G Sbjct: 122 CLDQHSLIPATASAVWEIIKRTGIQTFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGGD 181 Query: 184 CTTTVTHRFTK--NLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG--- 238 T T+ HR+T L+ H + AD++IVA G P I D +KEGA VIDVGIN + + Sbjct: 182 ATVTIAHRYTPKEQLKIHTQLADIIIVAAGIPKLITSDMVKEGAAVIDVGINYVHDPVTG 241 Query: 239 --KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 K+VGDV FE K+A +ITPVPGGVGPMTVA L++NTL A + Sbjct: 242 KTKLVGDVDFEAVKKKAGFITPVPGGVGPMTVAMLLKNTLLAAKK 286 >UniRef50_A2BX55 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=cellular organisms RepID=FOLD_PROM5 Length = 298 Score = 324 bits (831), Expect = 2e-87, Method: Composition-based stats. Identities = 121/286 (42%), Positives = 181/286 (63%), Gaps = 5/286 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 + +DGK ++ ++ ++ + +++ I + R PGLAV+ +G +PAS +YV +K +AC V Sbjct: 1 MSLKLDGKKLSLEIEEKLKKDIESNINSTKRPPGLAVIRIGEDPASGVYVKNKERACARV 60 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S + L +T + E+ +LI+ LN DN IDG+L+QLP+P D +++ I+PDKDVD Sbjct: 61 GIKSFIFHLKDTIDQKEVEQLINKLNLDNDIDGMLLQLPIPDKFDEQRLISLINPDKDVD 120 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G + N+G+L + P +R CTP GIV LL NI G VV+G S +VG+P+S+ LL Sbjct: 121 GLNEKNIGKLVKNEPGMRSCTPAGIVNLLRSQNITIEGKKIVVVGRSLLVGKPLSLMLLN 180 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG--- 238 T T+TH T NL+ + AD+LI A GKP I ++K+GA++IDVGI+RL + Sbjct: 181 LNGTVTITHSKTINLKKICKEADILIAAAGKPNLINSSYVKDGAVIIDVGIHRLTSSDKS 240 Query: 239 --KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 K+ GDV+ ED + TPVPGGVGPMTV L+ NT+ + + Sbjct: 241 QTKLCGDVLLEDVIPKVYAYTPVPGGVGPMTVTMLLVNTIFSWQKQ 286 >UniRef50_Q03RR1 Methenyltetrahydrofolate cyclohydrolase n=22 Tax=Bacteria RepID=FOLD_LACBA Length = 288 Score = 324 bits (831), Expect = 2e-87, Method: Composition-based stats. Identities = 137/281 (48%), Positives = 180/281 (64%), Gaps = 3/281 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 IIDGK IA+ + ++ A +V A + PGLAV++VG +PAS IYV +K K ++ Sbjct: 1 MTTIIDGKQIAKDLNAQTATRVAALKKRDIV-PGLAVIVVGDDPASAIYVRNKHKKALKL 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S +LP TT++AEL +++ N D TI GILVQ PLPAG+D ++ I P KDVD Sbjct: 60 GIKSVVRELPATTTQAELTQIVMAYNVDPTIHGILVQSPLPAGLDEQAIVAAIDPQKDVD 119 Query: 122 GFHPYNVGRLCQRAPRLRP--CTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 GFHP NVGRL P P CTPRGI+T+L + G AVV+G S IVGRPM+ L Sbjct: 120 GFHPLNVGRLFANLPGKYPVSCTPRGIMTMLATLPMHLRGKRAVVVGRSLIVGRPMAAML 179 Query: 180 LLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGK 239 L A T +V H T++L AD+L+VA G I +K GA+VIDVG++R ENGK Sbjct: 180 LNADMTVSVAHVHTQHLSDLTRTADVLVVATGVTHLIKATDVKPGAVVIDVGMDRDENGK 239 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 + GDV F++ A R + ITPVPGGVGPMT+ATL++ T+ C Sbjct: 240 LTGDVDFDNVAPRVAAITPVPGGVGPMTIATLMQQTVDLCE 280 >UniRef50_A8ZTQ4 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=Bacteria RepID=FOLD_DESOH Length = 303 Score = 324 bits (831), Expect = 2e-87, Method: Composition-based stats. Identities = 136/301 (45%), Positives = 175/301 (58%), Gaps = 17/301 (5%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M+AK+I G I +++ E+ +V+ + PGL +LVG +PAS YV K + Sbjct: 1 MSAKLIKGTEIREEILKEIEAEVKEIKEKHGKVPGLVTILVGESPASISYVTLKIQTAHR 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VGF P SEA+LL LID N D++I GILVQLPLP ID KVL I PDKDV Sbjct: 61 VGFKEVQDSQPVDISEADLLALIDKYNKDDSIHGILVQLPLPKHIDEKKVLNAIDPDKDV 120 Query: 121 DGFHPYNVGRLCQR--APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSME 178 DGFHP NVGRL + PCTP GI ++ R ++T G VV+G SNIVG+P++ Sbjct: 121 DGFHPVNVGRLMIGGSEVKFPPCTPAGIQEMIVRAGVETSGAEVVVVGRSNIVGKPIANM 180 Query: 179 LLLAG----CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINR 234 +L G T TV H TKN+ H + AD+LIVA G PG + +WIK GA VIDVG+NR Sbjct: 181 MLQKGPGANATVTVVHTRTKNMDEHCKRADILIVAAGVPGLVKPEWIKPGACVIDVGVNR 240 Query: 235 LENGK-----------VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 + + GDV F+ A + A ITPVPGGVGPMT+ L+ NTL++ Sbjct: 241 VGEKPSAKDPNKMVAILSGDVDFDAAKEIAGSITPVPGGVGPMTITMLMLNTLKSLKFKL 300 Query: 284 D 284 Sbjct: 301 G 301 >UniRef50_C3K8G7 Putative histidine biosynthesis-related tetrahydrofolate dehydrogenase n=1 Tax=Pseudomonas fluorescens SBW25 RepID=C3K8G7_PSEFS Length = 314 Score = 324 bits (831), Expect = 2e-87, Method: Composition-based stats. Identities = 138/289 (47%), Positives = 182/289 (62%), Gaps = 4/289 (1%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A+ IDGK I+ +V EV ++V + + P LAV+LVG +PAS +YV +K ++VG Sbjct: 12 ARDIDGKAISARVLDEVREEVLLLASQQIY-PALAVLLVGDDPASHVYVRNKLLRAKDVG 70 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 S Y LPE S+ ++L+L+ LNAD +++GILVQLPLPA ID V+ I P KDVDG Sbjct: 71 IRSLEYRLPEDASQTQVLDLLAQLNADTSVNGILVQLPLPAQIDEAAVIHAIDPIKDVDG 130 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 FH NVG L Q L PCTP G + LL D GL+AVVIG SNIVG+PM+ LL A Sbjct: 131 FHRENVGGLVQGIEVLTPCTPSGCMRLLHETCGDLSGLHAVVIGRSNIVGKPMATLLLQA 190 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN---GK 239 C+ +V H + + AD+++ AVG+P I W+K GA+VIDVGINR+ + Sbjct: 191 NCSVSVVHSRSVDAPALCRLADIVVAAVGRPQLIDARWLKPGAVVIDVGINRITTETGTR 250 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQDE 288 +VGDV + A AS ITPVPGGVGPMT+A L++NTL A +E Sbjct: 251 LVGDVDYASARTVASAITPVPGGVGPMTIAYLLKNTLVASQLQRSKANE 299 >UniRef50_UPI00016C0DE6 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016C0DE6 Length = 282 Score = 323 bits (829), Expect = 4e-87, Method: Composition-based stats. Identities = 127/279 (45%), Positives = 174/279 (62%), Gaps = 3/279 (1%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 K IDG IA ++ EV V+A GL+V+ V +N ++QIY+ +K+KAC+ VG Sbjct: 6 KKIDGTKIASIIKQEVKDAVEAMAPE---TVGLSVITVQTNSSAQIYIKNKQKACDYVGI 62 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S+ Y L E+++ +LELI+ LN +++DGILVQLPLP +D ++ I P KDVDGF Sbjct: 63 KSQIYTLDESSTTNNVLELIEVLNDSHSVDGILVQLPLPKHMDQSTIIAAISPSKDVDGF 122 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 N+ L CTP GI+ LL+ NI+ G V+IG SNIVG+P+++ LL Sbjct: 123 SKENLAGLIAGGSSFESCTPLGIMALLKHENIEIAGKKCVIIGRSNIVGKPLALMLLNED 182 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T + H T NL + ++ AD+LI AVGK FI G IK A+VIDVGI ENGK+ GD Sbjct: 183 ATVCICHSKTVNLANEIKTADILISAVGKAKFITGAMIKPKAVVIDVGITHDENGKLCGD 242 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 V F+ A YITPVPGGVGPMT+A L++N ++A + Sbjct: 243 VDFDSCLGIAEYITPVPGGVGPMTIAMLLKNCVRAAQLH 281 >UniRef50_Q2SRE7 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=Mollicutes RepID=FOLD_MYCCT Length = 284 Score = 323 bits (829), Expect = 4e-87, Method: Composition-based stats. Identities = 123/282 (43%), Positives = 178/282 (63%), Gaps = 1/282 (0%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+DGK +++ + V Q++ + G R P LAV+L+G++ AS++YV++K KAC VG Sbjct: 3 ILDGKLVSKTRKQLVKQQIDIYLNKGYRKPKLAVILIGNDQASELYVSNKIKACNLVGIE 62 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S E + L + I+ LN D +D IL+QLPLP ++ L+ I P KDVDGFH Sbjct: 63 SMLLRFDENINSQTLSDQINQLNNDQLVDAILLQLPLPKHLNEQMFLQAITPLKDVDGFH 122 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 N G++ + + PCTP GI+ LL+ YN+D + +IG SNIVG+P+++ L G Sbjct: 123 YINQGKMLEGYDTIYPCTPIGIINLLKAYNVDVKSKDITIIGTSNIVGKPLAIMLSNMGA 182 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE-NGKVVGD 243 T ++ ++ TK+L+ + + +D++I A GK I D IK+ AIVIDVGI R K+VGD Sbjct: 183 TVSMCNKNTKSLKKYTKISDIVISATGKQFIITKDMIKKNAIVIDVGIIRDPITNKIVGD 242 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDP 285 V FE+ + SYITPVPGGVGPMTVA L+ENTLQ ++ Sbjct: 243 VDFENVKELCSYITPVPGGVGPMTVAMLLENTLQLYKKHIKE 284 >UniRef50_Q4T2B9 Chromosome undetermined SCAF10300, whole genome shotgun sequence n=10 Tax=cellular organisms RepID=Q4T2B9_TETNG Length = 348 Score = 320 bits (821), Expect = 3e-86, Method: Composition-based stats. Identities = 110/318 (34%), Positives = 164/318 (51%), Gaps = 37/318 (11%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAA-GLRAPGLAVVLV-------------------- 41 A II G ++ +R + V+ + P L ++ Sbjct: 24 ATIISGNKTSRLLRDRLKADVEEMKSLFSGFRPALVILQPWAELLGQKLLRLLVLTSVFL 83 Query: 42 ------GSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGI 95 G S +Y+++K KA E+G ++ LP + ++ E+L I ++N D ++ G+ Sbjct: 84 VTLLQVGDRDDSNLYISAKMKAAAEIGIDAKHVRLPSSATQEEVLLNILSINEDQSVHGL 143 Query: 96 LVQLPLPA--GIDNVKVLERIHPDKDVDGFHPYNVGRLCQRA--PRLRPCTPRGIVTLLE 151 +VQLPL + ID+ + + DKDVDG N GRL + PCTP G + L+ Sbjct: 144 IVQLPLDSVHHIDSECITNTVSADKDVDGLSCINAGRLSRGDLDACFLPCTPSGCLELIR 203 Query: 152 RYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVG 211 + + G AVVIG S IVG PM LL T T H T +L V AD+L+V G Sbjct: 204 QTGVSLEGKQAVVIGRSKIVGAPMHDLLLWNHATVTTCHSKTPDLPEQVGRADILVVGAG 263 Query: 212 KPGFIPGDWIKEGAIVIDVGINRLEN------GKVVGDVVFEDAAKRASYITPVPGGVGP 265 + + G+W+KEGA+VID GIN++ + +VVGDV + A +RA +ITPVPGGVGP Sbjct: 264 RAEMVRGEWLKEGAVVIDCGINQVPDCTRASGKRVVGDVHYASAHQRAGFITPVPGGVGP 323 Query: 266 MTVATLIENTLQACVEYH 283 MTVA L++NT+++ Y Sbjct: 324 MTVAMLMQNTVRSAQRYL 341 >UniRef50_C8PD95 Putative uncharacterized protein folD n=1 Tax=Lactobacillus iners DSM 13335 RepID=C8PD95_9LACO Length = 301 Score = 319 bits (819), Expect = 5e-86, Method: Composition-based stats. Identities = 115/280 (41%), Positives = 173/280 (61%), Gaps = 2/280 (0%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+DGK A+++ E+ +V+ A + P V+ VG +PAS+IY+ KRK +++G Sbjct: 21 ILDGKEPAKKIIDELTLEVEHLKAKNIL-PTFCVIEVGEDPASKIYLRLKRKLAKKIGIN 79 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 ++ P + EL++ I LNAD +D I+VQLP+P I+ VLE I P KD DGF Sbjct: 80 EQTIKFPGDIRQDELIDKIKELNADPHVDAIMVQLPIPEHINTRLVLEAIDPTKDADGFT 139 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 PYN GR+ Q + P T R I+T+L+ Y ++ G NA++IG S IVG+P++ +LL Sbjct: 140 PYNQGRMWQGQVNIIPATVRSIMTILDYYQLNVEGKNALIIGRSIIVGKPVASQLLARNA 199 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+ H T+NL+ D++I VG+ I + +K G+I+IDVG+NR ENGK++GD+ Sbjct: 200 TVTIAHSHTRNLQELTLLNDIIISDVGRAHLITKNMVKPGSILIDVGMNR-ENGKLMGDI 258 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 ++D A ITPVPGGVGP+TVA L++ + H+ Sbjct: 259 EYDDCLPIAEAITPVPGGVGPLTVANLMKQVIILTKLRHN 298 >UniRef50_A6LU44 Methenyltetrahydrofolate cyclohydrolase n=22 Tax=Clostridium RepID=FOLD_CLOB8 Length = 282 Score = 319 bits (819), Expect = 5e-86, Method: Composition-based stats. Identities = 117/280 (41%), Positives = 172/280 (61%), Gaps = 1/280 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 +II+GK +A +V+ E+ V R L+ P +A +LVG++ S Y+ S+ K + Sbjct: 1 MGQIINGKEVALKVKEEIKNFVNNRKEKNLQVPKIASILVGNDGGSIYYMGSQEKVANSL 60 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G LPET ++ +++ I+ LN DN I GI++QLPLP D K++++I P+KD+D Sbjct: 61 GVEFLKLTLPETCNDEDVIAEINKLNEDNNIHGIILQLPLPNNFDEKKIIKQISPNKDID 120 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 + G+L P+ PCTP ++TL++ NID G N VV+G SNIVG+P++ LL Sbjct: 121 CLTFESQGKLYMGEPKFLPCTPNSVITLIKSLNIDIVGKNVVVLGRSNIVGKPVAQLLLN 180 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 T T+ H TKNLR +NAD+L+VA+G+P FI ++ E AIVIDVG + E GK+ Sbjct: 181 ENATVTICHSKTKNLREVCKNADILVVAIGRPKFIDETYVNENAIVIDVGTSSFE-GKIT 239 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 GDV F+ + Y+TPVPGGVG +T LI+N +A E Sbjct: 240 GDVDFDKVIDKCRYLTPVPGGVGSLTTTLLIKNACEALQE 279 >UniRef50_C7N2I9 Methenyltetrahydrofolate cyclohydrolase /5,10-methylenetetrahydrofolate dehydrogenase (NADP+) n=7 Tax=Bacteria RepID=C7N2I9_SLAHD Length = 284 Score = 319 bits (819), Expect = 6e-86, Method: Composition-based stats. Identities = 98/282 (34%), Positives = 148/282 (52%), Gaps = 3/282 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A+I+ GK +A + ++A +++A A P LA++ VG Y K E + Sbjct: 1 MAEILYGKPVADAINEKLAPRIEALKA-AGVTPQLAILRVGERDDDLSYERGAIKRFEAL 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G R + LPE S++ELL ++D +N D +I G L+ PLP +D E + P+KD D Sbjct: 60 GLDCRRFVLPENCSQSELLNVVDWINKDESIHGCLMFRPLPKHLDEAAACEALAPEKDAD 119 Query: 122 GFHPYNVGRLCQRAP-RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 G ++ + P PCT + +L Y + G V+G S ++G+P+SM L Sbjct: 120 GITEGSLFGVFANRPVGFPPCTADACMKVLSHYGYELTGAKLAVVGRSLVIGKPVSMMLQ 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE-NGK 239 A T T+ H TK+L AD+L+VA G G + ++EG +VIDVGIN + GK Sbjct: 180 AANATVTMCHTRTKDLSAACREADILVVAAGHIGTVGASEVREGQVVIDVGINWDDAAGK 239 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 + GDV F++ + ITPVP GVG +T A L E+ + A Sbjct: 240 LCGDVTFDEVEPVVAAITPVPRGVGSVTTAVLAEHVVTAAER 281 >UniRef50_Q14NV1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Spiroplasma citri RepID=FOLD_SPICI Length = 286 Score = 319 bits (819), Expect = 6e-86, Method: Composition-based stats. Identities = 122/277 (44%), Positives = 176/277 (63%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 KIIDGK +++ +++++ +++ A R P L ++ +G+N AS Y+ +K+ ACE+VG Sbjct: 5 KIIDGKMVSELIKAKITEQILKIKAKKQRVPALTIIQIGNNKASTTYIKNKKIACEKVGV 64 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + + P+ +E+ L+++I+ LN ++ ID ILVQLPLP+ I++ KV+ I KDVDGF Sbjct: 65 TCKVLNYPDIITESALIKIINDLNNNSKIDAILVQLPLPSHINSEKVINTIITKKDVDGF 124 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 P +G L L P TP+GI+ LL+ Y I G + V+IG SNIVG+P++ L+ A Sbjct: 125 TPKILGNLMLGHYNLLPSTPKGIIALLKHYQIQLAGQHVVIIGRSNIVGKPLANLLINAS 184 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T TV H TKNL AD+LI AVGK F+ + IKE IVIDVGINR E+ + GD Sbjct: 185 ATVTVCHSQTKNLSDFTNQADILISAVGKAKFVTAEMIKENVIVIDVGINRDEDNNLCGD 244 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 + F + + ITPVPGGVGPMT+A L+EN L Sbjct: 245 IDFHNVFSKVKMITPVPGGVGPMTIAALLENILYFYQ 281 >UniRef50_C5R8B8 Bifunctional protein: methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase n=1 Tax=Weissella paramesenteroides ATCC 33313 RepID=C5R8B8_WEIPA Length = 303 Score = 319 bits (818), Expect = 6e-86, Method: Composition-based stats. Identities = 144/291 (49%), Positives = 191/291 (65%), Gaps = 5/291 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 AKIIDGK IA+++RS V+++ PGLAV+LVG +PAS+IYV +K +A ++V Sbjct: 8 MAKIIDGKEIAKKLRSAVSEQAAILKEQS-VIPGLAVILVGDDPASEIYVRNKERAAKKV 66 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + ++ P T +E E+L+ + LNAD+TID ILVQ P+P+ I+ KV E I P KDVD Sbjct: 67 GVHAVTFKYPSTATEKEILDKVAELNADDTIDAILVQSPVPSQINEQKVQEAIIPSKDVD 126 Query: 122 GFHPYNVGRLCQRAPRLRP--CTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 GFHP NVGRL P TPRGI+T+L+ ID +AVVIG S +VGRPM L Sbjct: 127 GFHPENVGRLYANQAGYYPIANTPRGIMTMLQHEKIDLLNKHAVVIGRSILVGRPMFALL 186 Query: 180 LLAGCTTTVTHRFTKN--LRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 A + T+ HR+T R + AD+++VA G P + G +K GA+VIDVGINRL N Sbjct: 187 QAADTSVTLLHRYTPAALRRELLATADVVVVATGVPDLVMGADLKPGAVVIDVGINRLPN 246 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQDE 288 K+VGDV F A K AS ITPVPGGVGPMT+ATL++ T++ E+H + E Sbjct: 247 NKLVGDVNFGTAEKVASAITPVPGGVGPMTIATLLQTTVELAAEHHQIELE 297 >UniRef50_C0GE27 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GE27_9FIRM Length = 278 Score = 319 bits (817), Expect = 8e-86, Method: Composition-based stats. Identities = 113/280 (40%), Positives = 157/280 (56%), Gaps = 2/280 (0%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M+A+IIDG +A +++ ++ Q V + + PGLA+V+V S A + K++ CE+ Sbjct: 1 MSARIIDGSAVAGELQQQIKQDVAKLKSENKQLPGLAIVVVSSPKARKNIAELKKRMCEK 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG + L + + +++ LI+ LN D I GI + P+P ID V++ + P KDV Sbjct: 61 VGIHCEIHKLNPLSGQDDVIALIEKLNKDPKITGINIH-PVPDHIDYRAVVQALDPAKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 +G HP N G + P TPR I+ LLE D G AV++G S VG P+ LL Sbjct: 120 EGVHPMNQGNFLIGDKKFIPFTPRAIMRLLESTGEDLKGKRAVIVGRSQHVGLPVGFLLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T T H + L AD+LIVA G P I G IK GAIVIDVG N + G++ Sbjct: 180 EKHATVTYAHSRSWYLEDVTRLADILIVAAGHPEMITGSMIKPGAIVIDVGTN-IVGGQL 238 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 VGDV A + A +ITPVPGGVGPMTVA L+ N ++ C Sbjct: 239 VGDVEHHTAQRVAGWITPVPGGVGPMTVAMLLMNLVECCE 278 >UniRef50_A8IFV5 5,10-methylenetetrahydrofolate dehydrogenase (Fragment) n=1 Tax=Chlamydomonas reinhardtii RepID=A8IFV5_CHLRE Length = 301 Score = 318 bits (815), Expect = 2e-85, Method: Composition-based stats. Identities = 124/295 (42%), Positives = 174/295 (58%), Gaps = 15/295 (5%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A I+DG+ +A E+ V R PGL VVLVGS P S +YV K++AC++ G Sbjct: 1 AVILDGRAVAAAWERELVGDVARLTELLGRPPGLGVVLVGSRPDSMLYVTKKQEACQKAG 60 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 + + LP+T S+++L + + AD +DG+L+QLPLP + V+E + P KDVDG Sbjct: 61 MNTYVHHLPDTVSQSQLEAALAHVCADGRVDGVLIQLPLPRHLSEEAVMEVLDPRKDVDG 120 Query: 123 FHPYNVGRLCQRAPR--LRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 FHP N+GR+ R L P TP G + LL R +D G N VV+G SNIVG P++ L Sbjct: 121 FHPLNMGRMLMRGRGVRLVPATPLGCIELLRRSGVDVQGKNCVVLGDSNIVGTPLAAMLR 180 Query: 181 LAG-CTTTVTHRF-------TKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGI 232 G T+ HR + L +AD+L+VAVG P + GDW++ GA+VIDVGI Sbjct: 181 DKGAAAVTICHRRSYRECFQSYQLPDLTRSADILVVAVGHPELVRGDWVRPGAVVIDVGI 240 Query: 233 NRLEN-----GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 N + +VVGDV F++ ++ A ITPVPGG+GPMT+A ++ NTL+A Sbjct: 241 NVVSTLPRSPPRVVGDVAFDEVSRVAGAITPVPGGIGPMTIAAVLHNTLKAAKYR 295 >UniRef50_C8W0Y6 Methylenetetrahydrofolate dehydrogenase (NADP(+)) n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8W0Y6_DESAS Length = 287 Score = 317 bits (814), Expect = 2e-85, Method: Composition-based stats. Identities = 127/287 (44%), Positives = 186/287 (64%), Gaps = 5/287 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 MAA+++ GK IA +++ EV+ +V+A A P L + VG N AS +Y +++K E Sbjct: 1 MAAELLKGKPIADKIKVEVSAEVEALKAK-GVTPFLVAIQVGENAASAVYTGAQKKVAES 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G +LP T++ EL++ I+ LNAD+ + GI++Q+PLPA ID +I KDV Sbjct: 60 LGIRYELRELPAETTQEELIKYIEGLNADDEVKGIILQMPLPAQIDARAAQWKIAYSKDV 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 +G P+NVG + APRL PCTP G V L++ +D +G VV+G S+IVG+P +M LL Sbjct: 120 EGMTPHNVGLVTYFAPRLAPCTPAGAVELIKSTGVDLYGKEVVVVGHSDIVGKPTAMLLL 179 Query: 181 LAGCTTTVTHRFTKN---LRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 CT T+ H T HV NA++++VAVG PG + G+WIKEGAIVID+GIN++ + Sbjct: 180 KEFCTVTICHIATGQRGLTAQHVGNAEIVVVAVGVPGIVKGEWIKEGAIVIDIGINKVGD 239 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 K+VGDV FE A+++A+YITPVPGG G T A L++N ++A + Sbjct: 240 -KIVGDVEFEAASEKAAYITPVPGGAGVATTAMLMKNLVEATKWQLE 285 >UniRef50_C5C958 Methenyltetrahydrofolate cyclohydrolase n=118 Tax=Actinobacteria (class) RepID=FOLD_MICLC Length = 303 Score = 317 bits (812), Expect = 4e-85, Method: Composition-based stats. Identities = 117/297 (39%), Positives = 167/297 (56%), Gaps = 12/297 (4%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M AK++DGK A ++ E+ +V A R PGL +LVG + SQ YVA K + C E Sbjct: 1 MTAKVLDGKATAAAIKEELRGRVAALAER-GRTPGLGTLLVGEDAGSQKYVAGKHRDCAE 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG S +LP +E ++L+++ LN D G +VQLPLP +D KVLE I PDKD Sbjct: 60 VGIESIQRELPADATEEQILDVVRELNEDPACTGYIVQLPLPKHVDTQKVLEAIDPDKDA 119 Query: 121 DGFHPYNVGRLCQ----RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMS 176 DG HP N+GRL PCTP G V LL + ++ G + +VIG +GRP Sbjct: 120 DGLHPMNLGRLVASVGGELDSPLPCTPAGCVELLRHHGVELAGKHVLVIGRGVTIGRPAG 179 Query: 177 MELLLA--GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINR 234 + L T T+ H T NL + +AD++I A G + + +KEG IV+DVG++R Sbjct: 180 LVLTRREVNATVTLAHTGTTNLDELLASADVVIAAAGSAHMVTPEQVKEGVIVLDVGVSR 239 Query: 235 L--ENGK--VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQD 287 + E+GK V+GDV ++A+++ P PGGVGPMT L+ N ++A D ++ Sbjct: 240 VTGEDGKSRVLGDVD-PAVKEKAAWMAPNPGGVGPMTRVMLLANVVEAAERAADGEN 295 >UniRef50_A5N5B5 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=Clostridiales RepID=FOLD_CLOK5 Length = 284 Score = 317 bits (812), Expect = 4e-85, Method: Composition-based stats. Identities = 104/283 (36%), Positives = 154/283 (54%), Gaps = 2/283 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 II GK +A + + ++V G+ P L ++ VG+ + Y K C + Sbjct: 1 MGLIIKGKPVADAISETLIKEVDNFKIQGII-PKLVIIRVGAKASDLAYEKGILKRCNGI 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + + PE S+ E + + LN D +DGI+V PLP +D + I P+KD+D Sbjct: 60 GIETYVKEFPEDISQREFIRELRRLNEDRNVDGIMVFRPLPKHLDENIIKYVITPEKDID 119 Query: 122 GFHPYNVGRLCQRAP-RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 F+P N+ ++ PCTPR ++ +L+ YNID G +VVIG S IVG+PMSM LL Sbjct: 120 CFNPINLAKVIAGDSTGFAPCTPRAVMEILKYYNIDVEGKFSVVIGRSMIVGKPMSMLLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T T H T +L AD+L+ +GK FI +IKEGA+VIDVGIN + GK+ Sbjct: 180 NENSTVTTCHSKTVHLDKICSQADILVAGIGKAEFIDSKYIKEGAVVIDVGINVDKYGKL 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 GDV + + +TPVPGGVG +T + L ++ ++AC + Sbjct: 240 CGDVDIKSCQWKNVIVTPVPGGVGTVTSSVLAQHVVEACKHKN 282 >UniRef50_D1CB15 Methylenetetrahydrofolate dehydrogenase (NADP(+)) n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CB15_THET1 Length = 285 Score = 316 bits (811), Expect = 4e-85, Method: Composition-based stats. Identities = 104/279 (37%), Positives = 168/279 (60%), Gaps = 1/279 (0%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 I+DGK +A+ +R ++ ++QA + P LAVVL P + +Y + +K +++G Sbjct: 7 NILDGKAVAKTIRQQLESQIQAFQTSRGYVPNLAVVLPSEEPDACLYAQNLQKWFQKLGL 66 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + L + ++ +L I +L + + G+++Q+PLP G+ + V E + P KDV+G Sbjct: 67 GCFVHQLSSSITQEDLCAYIRSLCSSADVHGVMIQMPLPDGVSYLSVAEALDPMKDVEGI 126 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 HPYN G L P++ P TP TL++ Y ID G N VVIG SN+VG+P + +L+ Sbjct: 127 HPYNFGLLSIGNPQVVPSTPMAAATLIDHYGIDVSGKNVVVIGRSNVVGKPFAQLMLMKH 186 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 + +V H +K++R + NAD++ VAVG+P + D ++EG IVID GIN + + ++VGD Sbjct: 187 ASVSVLHSRSKSIRDYTLNADIVAVAVGRPNTLTADMVREGVIVIDFGINFVND-RLVGD 245 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 V FE + AS+ITPVPGG+GP+T L N ++ + Sbjct: 246 VDFEAVSPLASFITPVPGGIGPLTNLMLASNLIKLALTQ 284 >UniRef50_Q189R8 Methenyltetrahydrofolate cyclohydrolase n=26 Tax=Bacteria RepID=FOLD_CLOD6 Length = 290 Score = 316 bits (809), Expect = 8e-85, Method: Composition-based stats. Identities = 97/284 (34%), Positives = 154/284 (54%), Gaps = 2/284 (0%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 +II GK +A ++ E+ ++V + P L +V VG+ Y K C+ +G Sbjct: 8 GQIIKGKPVADKISEELIKEVDLLV-KEGINPKLTIVRVGARSDDLSYERGALKRCQNIG 66 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 + +L E ++ E ++++ +N D ++GIL PLP ++ + I P+KDVD Sbjct: 67 ITTEVLELAEDITQEEYIDVLKRVNDDKNVNGILCFRPLPKHLNEEVIKYVIAPEKDVDC 126 Query: 123 FHPYNVGRLCQRAP-RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 F P N ++ + PCTP +V +L+ YN+D G V+G S +VG+P+SM LL Sbjct: 127 FSPINSAKVMEGDKSGFPPCTPTAVVEILKHYNVDLKGSKVTVLGRSMVVGKPVSMLLLS 186 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 T T+ H TKNL AD+LI A+G+ + ++K+GA+VIDVGIN E G + Sbjct: 187 EHATVTICHSKTKNLSGVAAEADVLIAAIGRAKMVDESFVKDGAVVIDVGINVDEEGNLC 246 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDP 285 GDV + S ITPVP GVG +T + L ++ ++AC ++ Sbjct: 247 GDVDTNAVLDKVSMITPVPAGVGSVTTSILAKHVVKACKLQNNK 290 >UniRef50_C0R292 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=Brachyspira RepID=FOLD_BRAHW Length = 281 Score = 316 bits (809), Expect = 8e-85, Method: Composition-based stats. Identities = 112/280 (40%), Positives = 171/280 (61%), Gaps = 4/280 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 + I+DG+ +A++++ + ++ + P + + + ++++Y +K E V Sbjct: 1 MSNILDGRELAKEIKERIKKETEILEKK----PRIDFLYFEDDKSTEVYFTRAKKQAESV 56 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + ++LP T+E + L LI+ LN ++ GI++Q+PLP I KV E I +KD D Sbjct: 57 GMIGSLHNLPVNTTEKDFLTLIEYLNEESETSGIMIQMPLPKHISKKKVYETISIEKDAD 116 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 N+GR+ L PCT + + L+E+ I+ G NAVVIG S IVG+P++ LL Sbjct: 117 AISHVNLGRIFIGDSNLAPCTAKSAMALIEKSGINIEGANAVVIGRSEIVGKPLAHLLLQ 176 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 T T+ H TKNL+ +NAD+L V++GK FI G++IKEGA+VIDVGIN LE+G + Sbjct: 177 KSATVTIAHSKTKNLKELCKNADILCVSIGKAEFITGEYIKEGAVVIDVGINVLEDGSLK 236 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 GDV FE+A+K ASYITPVP GVG +TV+ L++N L Sbjct: 237 GDVNFEEASKLASYITPVPNGVGSVTVSMLLDNVLYLHKN 276 >UniRef50_C9LM47 Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase n=1 Tax=Dialister invisus DSM 15470 RepID=C9LM47_9FIRM Length = 281 Score = 314 bits (805), Expect = 2e-84, Method: Composition-based stats. Identities = 113/277 (40%), Positives = 161/277 (58%), Gaps = 2/277 (0%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I+DGK A + ++ +++ LAV+L GS+ S +Y +KA G Sbjct: 2 ILDGKVTAAALEKDIRERIDVLKER-GCTLKLAVILAGSSKPSHMYAEFMKKAALSYGIG 60 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + Y+ PE E EL LI LN + +I GIL+ +PLP I K++E IHPDKD+DG Sbjct: 61 TELYEKPENVKEDELGALIQALNGNPSITGILMMMPLPGHIHEEKMIEMIHPDKDMDGLT 120 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 N GRL L TPR ++ +L+ Y I G +AV+IG SN++G+P++M L+ Sbjct: 121 TVNAGRLFSGKDGLFGGTPRAVMAILKHYGISVEGKHAVIIGRSNVIGKPVAMMLMQKNA 180 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+ H TKNL + AD+L+ AVGK G + D +K GAIV+DVGINR+ GK VGDV Sbjct: 181 TVTICHSRTKNLSEITQQADILVTAVGKAGCVTADMVKPGAIVLDVGINRIH-GKTVGDV 239 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 +E+ A +TPVPGGVG +T +IE+ ++A Sbjct: 240 DYENVFPVAGAVTPVPGGVGSVTTTMIIESIVKAGEH 276 >UniRef50_A8SN78 Putative uncharacterized protein n=1 Tax=Parvimonas micra ATCC 33270 RepID=A8SN78_9FIRM Length = 283 Score = 313 bits (802), Expect = 5e-84, Method: Composition-based stats. Identities = 106/282 (37%), Positives = 161/282 (57%), Gaps = 2/282 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 I+ GK +A ++ ++ V G + VG S Y + K + Sbjct: 1 MTTIMKGKEVAIALKEKIKAGVAELKEKGKVTTC-GFIRVGDRSDSIGYENAAIKVLSSL 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + PE +EA+ + ++ + D+++DG L+ PLPA ID+ V +I+P KD+D Sbjct: 60 GIECVQFHYPEDITEADFISELEKIGNDDSVDGFLLLRPLPAHIDDDLVGMKINPKKDID 119 Query: 122 GFHPYNVGR-LCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 G PYN+G + PCT ++ +LE Y++D G NAVV+G SN++G+P++M LL Sbjct: 120 GVSPYNIGEVFYPKEDSFIPCTAAAVIKMLEFYDLDLTGKNAVVLGRSNVIGKPVAMLLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T TV H T+NL+ +NAD+L+ A+GK F+ + +KEGAIV+DVG N ENGKV Sbjct: 180 AKNATVTVCHSRTQNLKEVCKNADVLVSAIGKAHFVTKELVKEGAIVVDVGTNYDENGKV 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 GDV F++ ++ ASYI PVPGG+G +T + L E L A + Sbjct: 240 TGDVDFDEVSEIASYINPVPGGIGSITTSVLAEKCLIAARKK 281 >UniRef50_D0N1T3 Bifunctional folD protein n=1 Tax=Phytophthora infestans T30-4 RepID=D0N1T3_PHYIN Length = 298 Score = 313 bits (802), Expect = 5e-84, Method: Composition-based stats. Identities = 118/295 (40%), Positives = 177/295 (60%), Gaps = 21/295 (7%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 AK++DGK ++++ +E+ + V P LA++LVG++ S+ YV K+ AC V Sbjct: 1 MAKLLDGKACSKEIEAELKELVPTL----NVTPTLALLLVGTDQDSKTYVRLKKNACTRV 56 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLE--RIHPDKD 119 G + ++L E+ AELL LI +LNADN++ GIL+QLPLP + + + P KD Sbjct: 57 GITPQVHELAESIEFAELLALIQSLNADNSVHGILLQLPLPDHLKLHEEELLEAVSPLKD 116 Query: 120 VDGFHPYNVGRLCQRAPR---------LRPCTPRGIVTLLERYNIDTFGLNAVVIGASNI 170 VDG H ++ RL + L+PCTP G + +L R I+ G + VVIG + Sbjct: 117 VDGLHSHHFARLAEPEKEEEGAVKTLQLQPCTPAGCLEILARNGIELAGKDVVVIGRGQL 176 Query: 171 VGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDV 230 VG P+S+ LL A T T H TKNL V A+++ V G+P + GDW+ EGA+V+DV Sbjct: 177 VGLPLSLMLLAANATVTTCHSKTKNLADKVRQAEVVFVGTGQPELVKGDWLAEGAVVVDV 236 Query: 231 GINRLEN------GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 GI+ +++ K++GDV F A++R S ITPVPGG+GPMT+A L++NT++ Sbjct: 237 GISYVDDASSKKGYKILGDVDFAAASERVSAITPVPGGIGPMTIAMLLKNTVECA 291 >UniRef50_C6LCK2 Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase n=7 Tax=Bacteria RepID=C6LCK2_9FIRM Length = 282 Score = 312 bits (801), Expect = 7e-84, Method: Composition-based stats. Identities = 96/281 (34%), Positives = 146/281 (51%), Gaps = 2/281 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 AK + GK + + + V A P LA++ VG NP+ Y K CE + Sbjct: 1 MAKQLLGKEVTAALNERIKANVAACQEK-GVNPTLAIIRVGENPSDISYEKGATKRCETL 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G LPE ++ ELL +ID +N D+ I G+L+ PLP +D + + +KDVD Sbjct: 60 GVACEKILLPEDVAQEELLAVIDKVNKDDKIHGVLLFRPLPKHLDQAVIENALAAEKDVD 119 Query: 122 GFHPYNVGRLCQRAP-RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 ++ + PCTP+ + +L+ Y ID G AVVIG S +VG+P +M L+ Sbjct: 120 CMTDLSMSGVFTGKKIGFPPCTPQACMEILDHYGIDCTGKKAVVIGRSLVVGKPAAMMLV 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T T+ H T ++ AD++IVA G+ G + +++KEG +IDVGIN GK+ Sbjct: 180 KKNATVTICHTRTVDMPSVAREADIIIVAAGRAGVVGAEYVKEGQTIIDVGINVNAEGKL 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 GDV + ITPVPGGVG +T + L+ + ++A + Sbjct: 240 CGDVDYAAVEPIVDAITPVPGGVGSVTTSVLVGHVVEAAMR 280 >UniRef50_Q254F7 Methenyltetrahydrofolate cyclohydrolase n=13 Tax=Chlamydiaceae RepID=FOLD_CHLFF Length = 287 Score = 312 bits (800), Expect = 8e-84, Method: Composition-based stats. Identities = 111/287 (38%), Positives = 175/287 (60%), Gaps = 14/287 (4%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 ++ G +A+++ ++ QK+ + PGLAVVL+G++PAS++YV K K +G V Sbjct: 2 LLKGTPVAERILEKLKQKI----SQSPTPPGLAVVLIGNDPASEVYVGMKVKKAMNLGMV 57 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 S+++ LP + ++L+LI+ LN D TI GILVQ+PLP +D+ +++ I P+KDVDG H Sbjct: 58 SKAHRLPSDATLTDILKLIERLNNDPTIHGILVQIPLPKHLDSNVIIQAISPEKDVDGLH 117 Query: 125 PYNV-GRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA- 182 P N+ L + PCTP ++ LL Y+I G + V+G SNIVG+P++ L+ Sbjct: 118 PVNMGKLLLGQLGGFSPCTPAAVIELLNYYDIPLQGRHVAVVGRSNIVGKPLAAMLMQKH 177 Query: 183 ---GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGK 239 T T+ H ++N ++ AD+++ AVG P FI + I A+++DVGI+R+ Sbjct: 178 PTTNATVTLLHSQSQNFTEILKTADIIVAAVGVPLFIQENMISPNAVIVDVGISRVATNN 237 Query: 240 -----VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 +VGDV F + + ITPVPGGVGPMTVA L++NT ++ + Sbjct: 238 DKGYMLVGDVDFNNVVTKCKAITPVPGGVGPMTVAMLMKNTWESYQK 284 >UniRef50_D1C3C2 Methylenetetrahydrofolate dehydrogenase (NADP(+)) n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C3C2_SPHTD Length = 286 Score = 311 bits (796), Expect = 3e-83, Method: Composition-based stats. Identities = 102/278 (36%), Positives = 157/278 (56%), Gaps = 2/278 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A ++G+ +A+ + +++ + P LA VL G + ++ YV + + + V Sbjct: 1 MAIALEGRPVARAILERAREELAEYVTQAGHPPELATVLAGDDASAAAYVRAIHRTFDRV 60 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G R LP +E+EL + ++ LNAD + GI++ PLP + + + P KDVD Sbjct: 61 GIPVRDVTLPGDVAESELRDAVERLNADPAVSGIIILHPLPRHLPAGIASQLVDPAKDVD 120 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G PY+ GRL P L P TP G + +LE Y I+ G +AVVIG S +VG PM++ L+ Sbjct: 121 GVTPYSAGRLAVGLPALPPSTPEGGMAILEHYGIEIAGSHAVVIGRSPVVGLPMALMLIA 180 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 A T TV H T +L AD+L+ A G+PG + + +K GA VID G++ + +G++V Sbjct: 181 ADATVTVCHSRTPDLPAMTRQADILVAAAGRPGLVRPEMVKPGATVIDFGVSFV-DGRMV 239 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 GDV + A +TPVPGG G +T A L++NTL+A Sbjct: 240 GDVE-PAVGEVAGALTPVPGGTGAVTNAILVQNTLRAA 276 >UniRef50_C4Z3I2 Methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase n=3 Tax=Clostridiales RepID=C4Z3I2_EUBE2 Length = 280 Score = 309 bits (791), Expect = 8e-83, Method: Composition-based stats. Identities = 96/279 (34%), Positives = 146/279 (52%), Gaps = 4/279 (1%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 + G +A + ++ ++++ P LA+V VG P Y K E+VGF Sbjct: 4 LKGLPVANAINEKIIEEMKDWK---GAIPHLAIVRVGERPDDMSYERGATKKMEKVGFRC 60 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 SY P + D +N D IDGIL+ PLP +D + RI KD+DG P Sbjct: 61 TSYTFPADIDNDTFQKEFDKINEDEDIDGILLLRPLPKHLDEKAIENRIASVKDLDGISP 120 Query: 126 YNVGRLCQRAP-RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 N+ ++ P PCT ++ +L+ +D G AVVIG S ++G+P++M L+ Sbjct: 121 MNLAKVYAGDPTGYGPCTAEAVIEMLDYAGVDLKGKRAVVIGRSLVIGKPVAMMLMKKNA 180 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T TV H T ++ + A++L+ A G + ++ +GA+VIDVGIN E+G + GDV Sbjct: 181 TVTVCHTKTVDMPGVCKGAEVLVAAAGVAKMVDKSFVADGAVVIDVGINVDEDGNLCGDV 240 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 FED A+ AS TPVPGGVG +T + L ++ L+A Sbjct: 241 DFEDVAENASVCTPVPGGVGSVTTSVLAKHLLKAAKARR 279 >UniRef50_C6CV64 Methylenetetrahydrofolate dehydrogenase (NADP(+)) n=1 Tax=Paenibacillus sp. JDR-2 RepID=C6CV64_PAESJ Length = 284 Score = 309 bits (791), Expect = 9e-83, Method: Composition-based stats. Identities = 92/286 (32%), Positives = 144/286 (50%), Gaps = 2/286 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 K++ K A QV + KV+ P +A +LV +PAS Y +K+K E++ Sbjct: 1 MTKLLKAKEAADQVYEGIRTKVEKWK-HNGIQPRMAAILVEGDPASAYYAGAKQKIAEKL 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + +E E+L+L++ LN D ++ GI+++LPLP + + + I P KDVD Sbjct: 60 GVAFTLHAFTAEVAEEEILQLVNRLNNDPSVHGIMLELPLPRHLSASTIEKAISPLKDVD 119 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G P N L P TP+ + LL+ Y G N ++G VG P+ L Sbjct: 120 GVTPANKLATVTGDSGLYPATPQSCIRLLQHYGYTLEGKNVTLVGRGQTVGLPLFHMLQR 179 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 T TV H T ++ H+ +A++ VAVG+P + + + ++ID GIN GK+V Sbjct: 180 ENATVTVCHSRTPDIASHLSHAEIAFVAVGRPNIVEQNMVHSDLVIIDAGINETPQGKMV 239 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQD 287 GDV + A+ ++PVPGGVG +T A L EN ++A + Sbjct: 240 GDVAID-VQSSAAAVSPVPGGVGTLTTAILYENLMKAIELQFGERK 284 >UniRef50_C4FZX7 Putative uncharacterized protein n=1 Tax=Abiotrophia defectiva ATCC 49176 RepID=C4FZX7_ABIDE Length = 283 Score = 308 bits (790), Expect = 1e-82, Method: Composition-based stats. Identities = 94/278 (33%), Positives = 149/278 (53%), Gaps = 1/278 (0%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 KII GK +A+ + +E+ K ++ R P L ++ VG P Y K + +G Sbjct: 2 KIISGKEVAEHITAELKNKAESLKKGNRRLPKLVIIRVGEKPDDLSYQKGAVKRMDMIGV 61 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + E + E + D +N D ++DGILV P+P +D +++ I+P KD+D Sbjct: 62 IHEEVHFEENVPKEEFYKEFDEINNDESVDGILVLRPIPKHLDEDRLMNTINPKKDIDAI 121 Query: 124 HPYNVGRLCQR-APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 P ++G+L PCT G++ +L+ + G +IG SN+VGRP+++ + Sbjct: 122 SPVSLGKLMTGDKNGFAPCTAAGVIEILKYAGVKIRGKKVTIIGRSNVVGRPLALLFVSE 181 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T TV H FT +++ +NA++L+ + GK I +++ E A+VIDVGIN ENGK+ G Sbjct: 182 DATVTVCHSFTADVKQAGKNAEILVASCGKAKLINSEYVAENAVVIDVGINFDENGKLCG 241 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 DV D A+ TPVPGGVG +T + L + L A Sbjct: 242 DVDINDIEAVAAACTPVPGGVGAVTTSMLAKQLLLAYE 279 >UniRef50_O65269 F6N23.28 protein n=1 Tax=Arabidopsis thaliana RepID=O65269_ARATH Length = 310 Score = 308 bits (789), Expect = 2e-82, Method: Composition-based stats. Identities = 114/292 (39%), Positives = 158/292 (54%), Gaps = 44/292 (15%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A +IDGK A+++R ++ +V + P Sbjct: 55 AIVIDGKAEAKKIRDDIKIEVSRMKESIGVVPA--------------------------- 87 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 E +SE E+L+ + N D ++ G+LVQLPLP+ +D +L + +KDVDG Sbjct: 88 ---------EDSSEEEVLKYVSGFNDDPSVHGVLVQLPLPSHMDEQNILNAVSIEKDVDG 138 Query: 123 FHPYNVGRLCQR--APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 FHP N+GRL R P PCTP+G + LL RYNI+ G AVVIG SNIVG P ++ L Sbjct: 139 FHPLNIGRLAMRGREPLFVPCTPKGCIELLHRYNIEFKGKRAVVIGRSNIVGMPAALLLQ 198 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-- 238 T ++ H T N AD+LI AVGKP + G WIK GA++IDVGI +E+ Sbjct: 199 KEDATVSIIHSRTMNPEELTRQADILISAVGKPNMVRGSWIKPGAVLIDVGIKPVEDPSA 258 Query: 239 ----KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 ++VGD+ + +A+K AS ITPVPG VGPMT+A L+ NTL + H+ Q Sbjct: 259 AGGERLVGDICYVEASKIASAITPVPGDVGPMTIAMLLSNTLTSAKRIHNFQ 310 >UniRef50_B2KB67 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Elusimicrobium minutum Pei191 RepID=FOLD_ELUMP Length = 288 Score = 307 bits (787), Expect = 3e-82, Method: Composition-based stats. Identities = 99/287 (34%), Positives = 153/287 (53%), Gaps = 8/287 (2%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I++GKT+A +R + + Q R L + ++ AS +Y+ + KA E+ G Sbjct: 2 ILEGKTLAAAIRENLPARAQICKTKLGRPLKLTGIGWAADYASYVYLDKEIKAAEKTGIT 61 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 D+ E TS E+L +I L+ D T+D ++V PLP ++ +++ E ++P KD+DG Sbjct: 62 GEVIDITEQTSHEEMLNIIKKLSTDETVDAVIVPKPLPRHLNTLEIWEALNPLKDIDGSS 121 Query: 125 PYNVGRLCQRAP--------RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMS 176 N+GRL P T ++ LL+ Y I G+ V+G S VG+P++ Sbjct: 122 VLNMGRLFMCKNWAEVEAMQGFAPATAMAVIKLLDFYKIKLSGVETGVLGRSATVGKPLA 181 Query: 177 MELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE 236 L T + H T +L + D++I A+GK F+ + +K GA+VIDVG N+ E Sbjct: 182 HMLSCKDATVKICHSKTPSLTSSLSQCDIVISAIGKAKFVTENMVKTGAMVIDVGTNQDE 241 Query: 237 NGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 NG GDV FE+ K S ITPVPGGVGP+T+A L+EN + + Sbjct: 242 NGVFCGDVDFENVKKITSAITPVPGGVGPVTLACLLENIIISGERKL 288 >UniRef50_UPI00017F08E4 PREDICTED: similar to MGC137793 protein n=1 Tax=Sus scrofa RepID=UPI00017F08E4 Length = 933 Score = 306 bits (785), Expect = 4e-82, Method: Composition-based stats. Identities = 104/255 (40%), Positives = 152/255 (59%), Gaps = 10/255 (3%) Query: 41 VGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLP 100 VG+ S +Y+ K KA +E+G + LP T +E+E+L+ I +LN D T+ G ++QLP Sbjct: 59 VGNRDDSNLYINVKLKAAKEIGIKAMHIKLPRTATESEVLKCITSLNEDLTVHGFILQLP 118 Query: 101 LPAG--IDNVKVLERIHPDKDVDGFHPYNVGRLCQRA--PRLRPCTPRGIVTLLERYNID 156 L + I+ ++ I P+KDVDG N G+L + PCTP+G + L+++ + Sbjct: 119 LDSENPINAEALINAIAPEKDVDGLTSINAGKLARGDLNDCFIPCTPKGCLELIKQTGVQ 178 Query: 157 TFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFI 216 G AVVIG S IVG PM LL T T H T NL V D+++VA GKP + Sbjct: 179 IAGRQAVVIGRSKIVGAPMHDLLLWNHATVTTCHSKTANLNEEVNKGDIVVVAAGKPEMV 238 Query: 217 PGDWIKEGAIVIDVGINRLEN------GKVVGDVVFEDAAKRASYITPVPGGVGPMTVAT 270 G+WIK GA+VID GIN + ++VGDV + +A +RA +ITPVPGGVGPMTVA Sbjct: 239 KGEWIKPGAVVIDCGINCKPDDTKPSGKRIVGDVAYSEAKERAGFITPVPGGVGPMTVAM 298 Query: 271 LIENTLQACVEYHDP 285 L+++T+++ + + Sbjct: 299 LMQSTVESAEHFLEK 313 >UniRef50_A8RJW5 Putative uncharacterized protein n=2 Tax=Clostridium bolteae ATCC BAA-613 RepID=A8RJW5_9CLOT Length = 281 Score = 306 bits (784), Expect = 6e-82, Method: Composition-based stats. Identities = 97/283 (34%), Positives = 145/283 (51%), Gaps = 4/283 (1%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 KI+ G ++ +++ +V Q ++ AP LA+V VG P Y K E G Sbjct: 2 KILKGAEVSAKIKEQVTQMMEGLE---GPAPKLAIVRVGEKPDDMSYERGAVKKMENFGL 58 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 ++Y PE S+++ +N D + GIL+ PLP I + + I P+KD+DG Sbjct: 59 RVQTYVFPEQISDSDFKAEFSAINRDPDVSGILLLRPLPKQIAETDIEKMIDPEKDLDGI 118 Query: 124 HPYNVGRLCQRAP-RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 P N+ ++ PCT ++ +L+ ID G N ++G S +VGRP+SM +L Sbjct: 119 SPANIAKVFAGDKTGFAPCTAEAVIEVLKANEIDMTGKNVTIVGRSMVVGRPLSMLMLKE 178 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T T+ H T++L A++L+ A GK + G + + AIVIDVGIN ENGK+ G Sbjct: 179 NATVTICHTRTRDLETECRRAEILVAAAGKAKMLDGRHVGQDAIVIDVGINVDENGKLCG 238 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDP 285 DV F AS TPVPGGVG +T A L ++ + A Sbjct: 239 DVDFPSIEPLASMATPVPGGVGAVTTAVLAKHLVLAGRRQRGN 281 >UniRef50_B0VGJ7 FolD bifunctional protein n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VGJ7_9BACT Length = 307 Score = 306 bits (784), Expect = 6e-82, Method: Composition-based stats. Identities = 101/294 (34%), Positives = 162/294 (55%), Gaps = 12/294 (4%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 K+++GK +AQ + + + IA P + ++ VG +PAS YV S + +++ Sbjct: 5 MEKVLNGKPVAQLIN----RTCSSLIANYGLKPQMVLIQVGDDPASTYYVQSIINSGKKL 60 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + L + SE ELL +++ N + ++GI++Q PLP I+ KV I+P KD+D Sbjct: 61 GCFCQMKILLDNISEQELLAILNEANHNPDVNGIMLQKPLPKHINESKVNSAINPAKDLD 120 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 HP N+G++ PCTP ++ + Y I+T G + V++G SN+VG+P++ LL Sbjct: 121 CLHPLNLGKIMLEEEGFLPCTPAAVLFCMLYYGIETQGKHIVILGRSNVVGKPLANILLW 180 Query: 182 A----GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE- 236 T TV H T NL + AD+LI A+GK F+ + +KE AI++DVGIN ++ Sbjct: 181 KRSFANATVTVCHSKTNNLAEFTKEADILITAIGKAEFVTPEMVKENAIILDVGINEIKL 240 Query: 237 ---NGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQD 287 VGDV + +A ITPVPGG+G +T + L N + AC++ + Sbjct: 241 ANGESNYVGDVNYSLCYDKALAITPVPGGIGRITTSVLFLNLVDACLKSRNTNK 294 >UniRef50_C8WXG8 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WXG8_ALIAD Length = 286 Score = 305 bits (782), Expect = 1e-81, Method: Composition-based stats. Identities = 104/284 (36%), Positives = 156/284 (54%), Gaps = 3/284 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A+ +DG+ A++V+ E+ ++V+ + P L +++ ++ S +V K + Sbjct: 3 MAQRLDGRRAAERVQEELKRRVEELASR-GILPKLVMLVSEADEVSLGHVRRKARFARGA 61 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G V+ L ID LN D+ +D ILVQLPLPAG D ++L R+ PDKDVD Sbjct: 62 GLVAEIRTFRAAEGPDALRSAIDRLNEDDEVDAILVQLPLPAGWDEGEILRRVRPDKDVD 121 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G HP N+G++ PR+ PCT RG+ LL ++ I G A VIG S +VG P++ + Sbjct: 122 GLHPENLGQMAYGLPRVWPCTARGVGELLHQHEIGVHGKVACVIGRSPLVGWPIAQWFMA 181 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 G T HR T ++ AD+++ A G PG + + ++ GA+VIDVG+ +G Sbjct: 182 HGATVVQCHRQTPSVAVWTRQADIVVSAAGAPGLVGAEEVRPGAVVIDVGLTYTADGP-R 240 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDP 285 GDV +RAS++TPVPGGVGPMTVA + +N C Sbjct: 241 GDVD-PGVRERASWLTPVPGGVGPMTVAMVAQNAFDLCAMRRGG 283 >UniRef50_B9K850 Bifunctional protein folD n=1 Tax=Thermotoga neapolitana DSM 4359 RepID=B9K850_THENN Length = 284 Score = 305 bits (781), Expect = 1e-81, Method: Composition-based stats. Identities = 98/279 (35%), Positives = 151/279 (54%), Gaps = 14/279 (5%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 ID K+IA+ + +V ++V P L V+ +P++ Y+ S++K E++G Sbjct: 16 IDCKSIAKSIEEDVRKRVDLL----SFTPKLVSVVGTDDPSTASYLRSQKKKAEKLGIDF 71 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 TS + L ++ L D ++G+ V PLP G+D +V + +KDV+G +P Sbjct: 72 EIIK----TSPGDFLSTLEKLAEDKNVNGVFVARPLPEGLDEKRVFSAVPVEKDVEGVNP 127 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG-- 183 N+G L PCT +V +LE + G ++G S VG+P+++ LL G Sbjct: 128 ENLGFLLYGEETFPPCTAEAVVKVLESV-TEISGKKVTIVGRSVTVGKPLAIMLLKKGRD 186 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T TV H T+NL +D+++VAVGK F+ D +KEGAIVIDVGIN + +GK GD Sbjct: 187 ATVTVCHSRTQNLGEITRASDIVVVAVGKAHFLKRDMVKEGAIVIDVGINYV-DGKWCGD 245 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 V A + + +TPVPGGVG +T A L E+ ++A Sbjct: 246 VD--SAVEEIAQVTPVPGGVGQITTALLFEHVVRAAERQ 282 >UniRef50_Q83FS2 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Tropheryma whipplei RepID=FOLD_TROWT Length = 295 Score = 304 bits (779), Expect = 2e-81, Method: Composition-based stats. Identities = 117/293 (39%), Positives = 158/293 (53%), Gaps = 9/293 (3%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M AK++DG ++ + + + P LA VLVG+NPAS+ YV SK + C+ Sbjct: 1 MVAKVLDGLAVSAGIFERLHRACCEL-ENNGVCPKLATVLVGNNPASRSYVLSKHRDCKN 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G S +LP TSE EL+ ++ LNA + + GI+VQLPLP ID KV+E I+PDKD Sbjct: 60 IGIQSTLIELPANTSEKELISKVEILNASSDVSGIIVQLPLPESIDQNKVIEAINPDKDA 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG HP N+G L + PCTP GIV LLE + I G VIG VGRP+ + L Sbjct: 120 DGLHPLNLGYLVTGKQGIVPCTPAGIVKLLEAHRITLEGKTIAVIGRGTTVGRPLGILLS 179 Query: 181 LAG--CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGIN---RL 235 G T H ++N+ AD+++ G + WIK GA+V+DVGIN Sbjct: 180 GKGVNATVINIHSRSRNISGLSRIADVVVACAGVKHIVEPSWIKPGAVVVDVGINQSGVS 239 Query: 236 ENGK--VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 +GK + GDV ASYI+PV GGVGPMT A L+ N + + Sbjct: 240 SSGKMILTGDV-HPLTKNIASYISPVVGGVGPMTRAMLMSNVINLSERDFRKR 291 >UniRef50_D2RNA3 Methylenetetrahydrofolate dehydrogenase (NADP(+)) n=2 Tax=Acidaminococcus RepID=D2RNA3_ACIFE Length = 272 Score = 304 bits (779), Expect = 3e-81, Method: Composition-based stats. Identities = 104/277 (37%), Positives = 155/277 (55%), Gaps = 7/277 (2%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M I+ GK +A+++R + +K + LA LVG NPA+ +Y S K Sbjct: 1 MEPIIMAGKPVAEEIRRNLREKFA------GKELTLATFLVGDNPAAHVYKRSLLKTAAS 54 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G +R +LPE S+ E + L+ D +DGIL +P P I ++++ ++ P+KD+ Sbjct: 55 LGIHTRDVELPEGASQEEAERALRALSEDPRVDGILPLVPFPWHISRMQLIRQLDPEKDM 114 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 D HP N G+L PCTPR + LL+ Y I G + V++G +VGRP+++ L+ Sbjct: 115 DCIHPINGGKLYLGITPWGPCTPRSCMALLDYYKIPLEGQHVVMVGYGEVVGRPLTLMLM 174 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T TV TKNL AD++I AVGKP I D I+EGA+V+DVGIN + +GK+ Sbjct: 175 GRYATVTVCRSRTKNLPAITRQADIIISAVGKPDLITEDMIREGAVVVDVGINSV-DGKL 233 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 VGDV +AS TPVPGGVG ++ ++E + Sbjct: 234 VGDVSEAAKKVKASAYTPVPGGVGVVSNLMVMETLTR 270 >UniRef50_C7MLE6 Methenyltetrahydrofolate cyclohydrolase /5,10-methylenetetrahydrofolate dehydrogenase (NADP+) n=4 Tax=Coriobacteriaceae RepID=C7MLE6_CRYCD Length = 293 Score = 304 bits (778), Expect = 3e-81, Method: Composition-based stats. Identities = 94/284 (33%), Positives = 145/284 (51%), Gaps = 3/284 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A+I + + + E + V A P LA++ VG+ P Y RK CE Sbjct: 1 MAQIWKAAPVVEALAEETDRLVAQVTAQ-GITPQLAIIRVGNRPDDISYERGARKRCEAR 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + +++L +++ EL+ I +N D I G L+ PLPA ++ + P KD+D Sbjct: 60 GIAATTFELAAESTQDELMTTIQHINDDPAIHGCLMLRPLPASLNEEAATAVLLPQKDID 119 Query: 122 GFHPYNV-GRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 G P ++ G Q PCT + ++ +L+ Y G N VIG S +VGRP+S+ L Sbjct: 120 GITPSSLFGVFAQETVGFAPCTAQAVIEVLDHYGAHLDGTNVCVIGRSLVVGRPVSLMLQ 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE-NGK 239 T T+ H T+ ++ AD+++ A+G+ I DW+ G +VIDVGIN K Sbjct: 180 KRNATVTMCHSHTRTIQQVCRQADIVVAAIGQAHTIDVDWVSPGQVVIDVGINWDSAASK 239 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 +VGDV F+ + + ITPVPGG+G +T A L ++ QA V Sbjct: 240 LVGDVDFDSVEPKVAAITPVPGGLGAVTSAVLCKHLAQAAVNQL 283 >UniRef50_Q7TU81 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Prochlorococcus marinus subsp. pastoris str. CCMP1986 RepID=FOLD_PROMP Length = 298 Score = 303 bits (777), Expect = 4e-81, Method: Composition-based stats. Identities = 117/288 (40%), Positives = 173/288 (60%), Gaps = 5/288 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 + +DGK ++ ++ + + R PGLAV+ +G +PAS +YV +K KAC V Sbjct: 1 MSLKLDGKKLSLEIEERLRNYILTNKTIAKRNPGLAVIRIGEDPASGVYVGNKEKACSRV 60 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S + L +T + E+ +L++ LN DN IDG+L+QLP+ D +++ I+P+KDVD Sbjct: 61 GIKSYIFHLKDTVEQKEVEQLLNKLNLDNNIDGMLLQLPISKKFDEQRLISFINPEKDVD 120 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G + N+G+L + +R CTP GIV LL+ NI G VVIG S +VG+P+S+ +L Sbjct: 121 GLNEQNIGKLVKNEQAMRSCTPAGIVNLLKSQNIKIEGKKIVVIGRSLLVGKPLSLMMLN 180 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG--- 238 T T+TH T NL + AD+LI A GKP I ++KEGA++IDVGI+RL + Sbjct: 181 LNATVTITHSKTINLNKICKEADILIAAAGKPNLINSSFVKEGAVIIDVGIHRLTSSDKS 240 Query: 239 --KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 ++ GDV+ ED + TPVPGGVGPMTV L+ NT+ + + Sbjct: 241 KTRLCGDVLLEDVIPKVFAYTPVPGGVGPMTVTMLLVNTIFSWQKQFG 288 >UniRef50_A5ILJ9 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=Thermotogaceae RepID=FOLD_THEP1 Length = 271 Score = 302 bits (774), Expect = 9e-81, Method: Composition-based stats. Identities = 96/280 (34%), Positives = 149/280 (53%), Gaps = 14/280 (5%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 ID +TIA+ + ++V+ P L V +P++ Y+ S+RK E++G Sbjct: 3 IDCRTIARSIEERTKERVEKL----GFTPKLVSVACTDDPSTLSYLKSQRKKAEKLGIAF 58 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 S E++ + L +D +++G+ V P P D ++L + +KDV+G +P Sbjct: 59 EIL----NVSPEEIVSTLKKLGSDESVNGVFVARPFPPSFDEKEILSSVPVEKDVEGVNP 114 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG-- 183 N+G L PCT V +LER + G V+G S VG+P+++ LL G Sbjct: 115 ANLGLLLYDEEIFPPCTAEAAVRILER-ETNLSGKRVTVVGRSVTVGKPLALMLLKKGRD 173 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T TV H T NL +N+D+++VAVG+ F+ + +KEGAIVIDVGIN + +GK+ GD Sbjct: 174 ATVTVCHSRTVNLEEITKNSDIVVVAVGRAHFLKKNMVKEGAIVIDVGINYV-DGKLQGD 232 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 V + A +TPVPGGVG +T A L E+ ++A Sbjct: 233 VD-PSVEEIAR-VTPVPGGVGQVTTALLFEHVVRAAERQR 270 >UniRef50_Q0S375 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=Actinobacteridae RepID=FOLD2_RHOSR Length = 286 Score = 302 bits (773), Expect = 1e-80, Method: Composition-based stats. Identities = 117/283 (41%), Positives = 157/283 (55%), Gaps = 5/283 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A I+DGK ++ ++ +V A PGL VLVG +P S YV K C + Sbjct: 1 MTATILDGKATRDEIFEDLKVRVSALKDR-GITPGLGTVLVGDDPGSAAYVRGKHNDCAK 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG S DLP ++ +L ID LNA+ G +VQLPLP +D LERI PDKD Sbjct: 60 VGITSIRRDLPGDITQEKLDATIDELNANPDCTGYIVQLPLPKQLDENAALERIDPDKDA 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG HP N+GRL PCTPRGI+ LL RY + G + VV+G VGRP+ + Sbjct: 120 DGLHPVNLGRLVLGKKAPLPCTPRGILHLLRRYEVPIEGAHVVVVGRGVTVGRPIGLLFT 179 Query: 181 LA--GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 T T+ H T++L V AD++I A G PG I D +K GA V+DVG++R +G Sbjct: 180 RRSENATVTLCHTRTRDLGAEVRRADIVIAAAGVPGLITADMVKPGAAVLDVGVSRTADG 239 Query: 239 KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 + GDV D A+ A +++P PGGVGP+T A L+ N ++ Sbjct: 240 -LRGDVA-ADVAEVAGFLSPNPGGVGPLTRAFLLTNVVERAER 280 >UniRef50_D1BP88 Tetrahydrofolate dehydrogenase/cyclohydrolase n=4 Tax=Veillonellaceae RepID=D1BP88_VEIPT Length = 275 Score = 301 bits (771), Expect = 2e-80, Method: Composition-based stats. Identities = 96/274 (35%), Positives = 151/274 (55%), Gaps = 4/274 (1%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 + GK +A ++ + +KV A G +AV+LVG + + +Y K + G+ Sbjct: 4 LRGKAVADAHKAILQEKVAAV---GNSVITMAVLLVGEDHGAHMYATFMEKTAKNFGYGF 60 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 LP+T ++ E++ + LN D +I GIL +P+P ID +++ + P KD+DG Sbjct: 61 VLKQLPKTATQDEVVAALHELNTDASIHGILPLMPMPKHIDTEALIDMLDPKKDIDGLTT 120 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCT 185 YN+G + PCT + + +L YNI + VV+G S ++G+P+++ L A T Sbjct: 121 YNIGLVTAGKGGFAPCTAKACMAILNHYNISVEEKHVVVVGRSQVIGKPIALMALSAHGT 180 Query: 186 TTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVV 245 T+ H T +L V+ D++I A G+ I + IK GA+VIDVGIN L +GK VGDV Sbjct: 181 VTMCHSRTPDLAEQVKRGDIVIAAAGRAHMITANMIKPGAVVIDVGINEL-DGKTVGDVD 239 Query: 246 FEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 ++ AS ITPVPGGVG +T ++E +A Sbjct: 240 YDAVKDIASAITPVPGGVGSVTTTMMLEAVYEAY 273 >UniRef50_Q21285 Dauer or aging adult overexpression protein 3, confirmed by transcript evidence n=2 Tax=Caenorhabditis RepID=Q21285_CAEEL Length = 303 Score = 301 bits (770), Expect = 3e-80, Method: Composition-based stats. Identities = 119/299 (39%), Positives = 163/299 (54%), Gaps = 11/299 (3%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAG-LRAPGLAVVLVGSNPASQIYVASKRKACE 59 M A+I+ G +++V +V QK+ LA+V VG+ S +Y+ SK K + Sbjct: 1 MVAEIVSGLEYSKKVLHDVGQKIAKTREHHPNFHAVLAIVQVGNRSDSNVYINSKLKKAK 60 Query: 60 EVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAG--IDNVKVLERIHPD 117 E+G + LP+T ++ +L I LN DN IDGI++QLPL ID V++ I P Sbjct: 61 EIGADGKLIKLPDTITQGDLKREIMALNHDNEIDGIIIQLPLDCKHEIDADSVIDLIDPL 120 Query: 118 KDVDGFHPYNVGRLCQRA--PRLRPCTPRGIVTLLERYNID---TFGLNAVVIGASNIVG 172 KDVDG N GRL + + PCTP G + L+++ D G VV+G S IVG Sbjct: 121 KDVDGLTRINAGRLARGELQRTIFPCTPFGCLYLVQQATGDANFVSGKEVVVLGRSKIVG 180 Query: 173 RPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGI 232 P + L T T+ H T NL+ AD+LIVA+G+ F+ DWIK GA VID GI Sbjct: 181 SPAAALFLWHHGTVTICHSKTPNLKEKCLRADILIVAIGRKHFVKADWIKPGAFVIDCGI 240 Query: 233 NRLENG---KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQDE 288 N ++ K+ GDV E A + A ++TPVPGGVGPMTVA LI NT + Q + Sbjct: 241 NVGDDPNSRKIYGDVDTEAAKEVAGFLTPVPGGVGPMTVAMLIRNTFEQAKRRRLGQKD 299 >UniRef50_B7AQ13 Putative uncharacterized protein n=3 Tax=Bacteria RepID=B7AQ13_9BACE Length = 286 Score = 300 bits (769), Expect = 3e-80, Method: Composition-based stats. Identities = 95/285 (33%), Positives = 142/285 (49%), Gaps = 6/285 (2%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A + G ++ ++ +V ++ P LA++ VG P Y K Sbjct: 7 MEA--LKGAAVSAAIKEQVQNRLAEL---DGYIPTLAIIRVGEKPDDISYEKGAMKKMAS 61 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 G +SY PE S+A E +NAD IDGIL+ PLP I + + I P KD+ Sbjct: 62 FGLNVQSYTFPEDISDALFKEEFAKINADKAIDGILMLRPLPKHICEKDIEKMIDPAKDL 121 Query: 121 DGFHPYNVGRLCQRAP-RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 DG P N+ ++ PCT ++ +L+ YNI G V+G S +VG+P+SM Sbjct: 122 DGISPENIAKVFAGDSTGFAPCTAEAVIEVLKAYNIPMQGKRVTVVGRSMVVGKPLSMLF 181 Query: 180 LLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGK 239 + T T+ H T +L+ A++L+ A G+ + + + A+VIDVGIN ENG+ Sbjct: 182 VKENATVTICHTRTADLKAECSRAEILVAAAGRARMLDSAYAGKDAVVIDVGINVDENGR 241 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 + GDV +E AS TPVPGGVG +T A L ++ +QA Sbjct: 242 LCGDVDYESLEGIASMATPVPGGVGAVTTAVLAKHLVQAAARARG 286 >UniRef50_A9NE96 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Acholeplasma laidlawii PG-8A RepID=FOLD_ACHLI Length = 277 Score = 299 bits (767), Expect = 6e-80, Method: Composition-based stats. Identities = 115/281 (40%), Positives = 158/281 (56%), Gaps = 5/281 (1%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 ++DG+ A + + KVQ P L ++L+G++ AS+ YV K +G Sbjct: 2 LLDGRKTADILNEALRVKVQYLTKK----PKLEIILIGNDEASKSYVKGKLNTASNLGME 57 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 L E + + LI LN D + GIL+QLP+P +D+ ++ I KDVDGFH Sbjct: 58 VHINYLDEAIDQLSVEALIQKLNTDKGVHGILLQLPIPKHLDSDYLISLIDYKKDVDGFH 117 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 N G L Q+ +RP TP GI+ LL+ YNI G + V+IG S IVG P+S L Sbjct: 118 TMNQGLLFQKKDGIRPATPLGIMMLLDFYNIPIEGKHVVIIGRSQIVGAPLSKMFLDRNA 177 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+TH TKNL + AD+L+ A+GKP F+ D +K GA+V+DVGINR+ + K+VGDV Sbjct: 178 TVTITHSKTKNLPSITKQADILVAAIGKPKFVTKDMVKVGAVVVDVGINRV-DKKLVGDV 236 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDP 285 FE ASYITPVP GVGPMT+ L N ++ Sbjct: 237 DFEHVEPIASYITPVPKGVGPMTICALAHNLYALYLKQEKE 277 >UniRef50_B5YA73 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Dictyoglomus RepID=FOLD_DICT6 Length = 283 Score = 299 bits (767), Expect = 6e-80, Method: Composition-based stats. Identities = 102/280 (36%), Positives = 155/280 (55%), Gaps = 2/280 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 I++GK +A+++ E+ +K++ G+ P L +V VG N ++ Y S + + Sbjct: 1 MGVILEGKPVAEKLEKEIKEKIEIYKTKGII-PNLCIVKVGENEEAEAYAKSIERFFSRI 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + E S E + + L +N + GIL+ PL ++ K + PDKDV+ Sbjct: 60 GINVERKNFAENVSLLEFQKALKELEKNNKVHGILILRPLSEELERQKAFRFLSPDKDVE 119 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G N+G+L PCTP+ ++ LL+ Y I G + VV+G S VG+P+S+ LL Sbjct: 120 GITYENLGKLFVGEKCFHPCTPQAVIELLDFYKISVEGKDVVVVGRSISVGKPLSILLLN 179 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 T T+ H TKNL A++L+ AVG+P FI D +KEG +VID+G N +E GK+V Sbjct: 180 RNATVTICHSKTKNLEELTRRAEVLVAAVGRPHFIGKDMVKEGQVVIDIGTNVVE-GKLV 238 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 GDV FE+ + YITPVPGG+G +T L N L+A + Sbjct: 239 GDVNFEEVKDKVGYITPVPGGIGIITTRVLAMNLLKAVEK 278 >UniRef50_Q0SFQ8 Methenyltetrahydrofolate cyclohydrolase n=11 Tax=Actinomycetales RepID=FOLD1_RHOSR Length = 297 Score = 297 bits (762), Expect = 2e-79, Method: Composition-based stats. Identities = 101/288 (35%), Positives = 152/288 (52%), Gaps = 2/288 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 + + G +A +R++ + A P LAVV + ++ YV S A + Sbjct: 1 MTRSLGGAELATSIRNDASVAAAALND-LGTRPKLAVVQATDDESTAWYVRSIASAAKRT 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + DL S ++ + L D + GI++Q PLP G D + E I+P KDVD Sbjct: 60 GILCDIVDLGAAASTEQIRSTLVELGHDPDVHGIILQTPLPDGTDLDALREAINPAKDVD 119 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G +P ++GRL R P P T + ++ LL+ + I A V+G S +VG P++ L+ Sbjct: 120 GANPVSLGRLVARLPAFAPATAQAVIALLDHHGISPHARTATVVGRSTVVGSPVAHLLVQ 179 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 T TV HR T +L +AD+L+VAVG PG I D + +GA+VIDVG +G+++ Sbjct: 180 RNATVTVCHRHTTDLAAGTRDADILVVAVGIPGLITADHVADGAVVIDVGTTATADGQLL 239 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC-VEYHDPQDE 288 GDV RA +TPVPGGVGP+T A L+ +T+ A +Y + E Sbjct: 240 GDVDAAAVDGRAGALTPVPGGVGPVTTALLLNHTVDAAGTQYAQTRSE 287 >UniRef50_C8WAB5 Tetrahydrofolate dehydrogenase/cyclohydrolase n=1 Tax=Atopobium parvulum DSM 20469 RepID=C8WAB5_ATOPD Length = 289 Score = 297 bits (762), Expect = 2e-79, Method: Composition-based stats. Identities = 96/278 (34%), Positives = 148/278 (53%), Gaps = 3/278 (1%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 + G +A+ + E+A +V+ A G+ P L +V +G Y + E+VGF Sbjct: 10 LRGAPVAKAITEELAVQVEELRAEGII-PRLVIVRIGQKSDDLTYERAAYMRAEKVGFEV 68 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH- 124 + +LPE ++ ++ D ++AD ++ G L P PAGID + L+ + P+KDVD Sbjct: 69 ETIELPEDATQKQVNTTFDQVSADASVHGCLPMRPFPAGIDEHEALQHLTPEKDVDCATD 128 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 + LC L PCT ++ LL+ Y + G + V+G SN++GRP++ L Sbjct: 129 SMLLATLCGTPGALGPCTAEAVLALLDFYQVPLEGASIAVVGRSNVIGRPVAALLSARNA 188 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-KVVGD 243 T TV H TK+L ++ AD+++VA G+ I D+++ G +IDVGIN E K+VGD Sbjct: 189 TVTVCHSKTKDLAATLKQADVVVVAAGRAHLIGADYVRAGQTIIDVGINWDEAAQKLVGD 248 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 V E A S TPVPGGVG +T A L + + A Sbjct: 249 VDTEQVAPLVSAYTPVPGGVGSVTTAILARHVVAAAQR 286 >UniRef50_A5CF58 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Orientia tsutsugamushi RepID=FOLD_ORITB Length = 301 Score = 297 bits (760), Expect = 4e-79, Method: Composition-based stats. Identities = 119/285 (41%), Positives = 155/285 (54%), Gaps = 6/285 (2%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 I+DGK +A+ E + A L ++LVG+N AS IYV +K + + Sbjct: 1 MTVIMDGKKLAELRLIETKNDLLALKDKYQITVKLVIILVGNNDASLIYVNNKVAKAKAI 60 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S L E E +L +ID LN D+T+ GI+VQLPLP ID +K+ RI KDVD Sbjct: 61 GMDSEIIRLFEFIEEKKLFSVIDDLNCDSTVHGIIVQLPLPPHIDALKLFARIDSRKDVD 120 Query: 122 GFHPYNVGRLCQRAP-RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 G +P N+G L A L PCT G + LL+ Y G + VVIG SNIVG+P+S LL Sbjct: 121 GLNPINIGYLNIGANQGLIPCTALGCIDLLQYYVTGLKGKHVVVIGKSNIVGKPLSALLL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN--- 237 CT T+ H T +L H AD++I AVGK F+ IDVGI+ + + Sbjct: 181 RNSCTVTICHSATVDLALHTRTADIVISAVGKANFLTDKHFSGNLAFIDVGISHIYDLQT 240 Query: 238 --GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 K+VGD F +ITPVPGGVGPMTVA L++NTL A Sbjct: 241 HKRKLVGDGDFLKIKDLVKFITPVPGGVGPMTVAYLLKNTLTAAK 285 >UniRef50_C2L112 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Oribacterium sinus F0268 RepID=C2L112_9FIRM Length = 281 Score = 294 bits (754), Expect = 2e-78, Method: Composition-based stats. Identities = 94/278 (33%), Positives = 139/278 (50%), Gaps = 4/278 (1%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 + GK +A+++ E V P LA++ VG A Y + +K G Sbjct: 4 LLGKPVAEEIEKEC---VAFLAERPGVMPALALIRVGERTADVTYEKAIKKRFLSFGLEV 60 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 +SY LP S + E+I LN D I GI+V PLP+ +D I +KDV+G Sbjct: 61 KSYQLPADCSNEQFQEVIQFLNGDEEIHGIMVFRPLPSHLDQETAFRMIKREKDVEGVSR 120 Query: 126 YNV-GRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 N+ G + + PCT + ++ + Y I G ++G S +VGRP+S+ + Sbjct: 121 ENMAGLILKDESAFAPCTAQAVMEMCRFYKIPLAGKEVCILGRSLVVGRPLSILMTNKDA 180 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+ H T N++ + AD+L+ +GK I + KEGA VIDVG NR E G +VGDV Sbjct: 181 TVTLCHSKTSNIKEVTKRADVLVCCMGKAKAIGSSYCKEGATVIDVGTNRDEKGNLVGDV 240 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 F+ A A I+PVP G+G +T A L + L+A Sbjct: 241 DFDTMATVAEKISPVPRGLGAVTTAVLAKQLLKAYRLQ 278 >UniRef50_UPI00006CCCC6 methylenetetrahydrofolate dehydrogenase n=1 Tax=Tetrahymena thermophila RepID=UPI00006CCCC6 Length = 342 Score = 294 bits (752), Expect = 3e-78, Method: Composition-based stats. Identities = 110/289 (38%), Positives = 164/289 (56%), Gaps = 9/289 (3%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGL--RAPGLAVVLVGSNPASQIYVASKRKACE 59 + + +G A+++ S + ++++ R PGL ++LVG+NPAS Y+ K +ACE Sbjct: 15 STVVFNGNKSAKKILSSLRKEIEWFQKQSDLSRKPGLGIILVGNNPASLSYIKKKLQACE 74 Query: 60 EVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKD 119 +G Y E E ++L ID LN + ID I+ QLPLP+ ID V+ I +KD Sbjct: 75 AIGIRHELYHFSEDIQEYDVLSAIDNLNRKDDIDAIMAQLPLPSHIDKNNVINMISSEKD 134 Query: 120 VDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 DG N L + PCTP + +LE + I + V+IG +VG+P+ L Sbjct: 135 ADGL-KLNSNNL-DPKANILPCTPAACLKILEEHQICLKDKHVVLIGRGRLVGQPLEQLL 192 Query: 180 LL-AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINR---- 234 + T + T +++ H+ AD++I A G+ I G WIK+GAIV+DVG+N+ Sbjct: 193 SKLSPAQITTCVKETGDIKQHILKADVIIAAAGERQLIKGKWIKKGAIVLDVGVNKGIPG 252 Query: 235 LENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 ++ KVVGDV FE+A KRAS ITPVPGG+GPMTV+ L+ NT+Q + Sbjct: 253 IDPTKVVGDVEFEEAKKRASLITPVPGGIGPMTVSMLMYNTVQIWKQRR 301 >UniRef50_C1FDF4 5,10-methylene-tetrahydrofolate dehydrogenase/cyclohydrolase n=1 Tax=Micromonas sp. RCC299 RepID=C1FDF4_9CHLO Length = 396 Score = 292 bits (748), Expect = 1e-77, Method: Composition-based stats. Identities = 122/338 (36%), Positives = 172/338 (50%), Gaps = 57/338 (16%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQ-ARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 +A ++DG+ A + + E+A K+ R + + PGLA V++G P S +YV K +ACEE Sbjct: 56 SAIMLDGRLQAARWKREIAAKILFRRTSKRMGPPGLAAVVIGDRPDSLLYVRRKSEACEE 115 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG LP + ++ ++ LN+D+ GI++QLP+P ++ ++L I+P KDV Sbjct: 116 VGIRFHLERLPGDADQDMVVNVLRKLNSDDRFHGIMLQLPVPVHLNESRLLGSINPMKDV 175 Query: 121 DGFHPYNVGRLCQR---APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSM 177 DG HPYNVGRL R P PC P G V LL R NI G + V+G SN+VG P+S Sbjct: 176 DGLHPYNVGRLAMRGTWRPAFIPCAPLGCVELLWRENIQIKGRSVAVLGDSNVVGMPISW 235 Query: 178 ELLLAGC-TTTVTHRF-------------------TKNLRHHVENADLLIVAVGKPGFIP 217 L +G T V H + NL + V NAD++I A+G+ I Sbjct: 236 LLRDSGASTINVVHGYWLKVPEQNNMKFPAQANFVEPNLLNTVRNADIIISAIGRAEVIK 295 Query: 218 GDWIKEGAIVIDVGINRLE---------------------------------NGKVVGDV 244 DW+K GA VIDVGIN + + KVVGDV Sbjct: 296 RDWVKAGATVIDVGINPIPWDHHEGIARCRHASSRKVPAAFLEQRPDKPEKSDYKVVGDV 355 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 E+ + A+ +TPVPGG+GPMT+A L+ NT Sbjct: 356 AAEEVSHVANAMTPVPGGIGPMTIAALLSNTYLGASRQ 393 >UniRef50_A9UXQ1 Predicted protein n=7 Tax=cellular organisms RepID=A9UXQ1_MONBE Length = 882 Score = 291 bits (746), Expect = 1e-77, Method: Composition-based stats. Identities = 124/297 (41%), Positives = 163/297 (54%), Gaps = 47/297 (15%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 AKIIDGK IAQ VG S +Y+ K +A E+ Sbjct: 1 MAKIIDGKAIAQ--------------------------YVGGRDDSAVYIRMKVRAGNEL 34 Query: 62 G-------FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAG--IDNVKVLE 112 + SR + L +LLE I LN D + GI+VQLPL + ID V + Sbjct: 35 PAVTFAHMYRSRLFCLA----HPQLLECIRALNDDMDVHGIIVQLPLDSQEEIDEVTITN 90 Query: 113 RIHPDKDVDGFHPYNVGRLCQRA--PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNI 170 + P+KDVDGF YN G L Q+ P L CTP+G + L+E I+ G +AVVIG S+I Sbjct: 91 AVRPEKDVDGFTRYNTGALAQKGELPLLYACTPKGCMHLIESTGIELSGKHAVVIGRSDI 150 Query: 171 VGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDV 230 VGRP+S L T T+ H T NL+ V AD+++ AVG+PG + GDW+K GA+VID Sbjct: 151 VGRPVSYLLTRRNATVTLCHSRTTNLKEEVARADIVVAAVGQPGLVQGDWLKPGAVVIDC 210 Query: 231 GINRLENG------KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 GIN +E+ ++VGDV F A++ A +ITPVPGGVGPMTVA L+ NT+ A Sbjct: 211 GINSIEDSSKKSGFRLVGDVDFASASQVAGHITPVPGGVGPMTVAMLMGNTVAAARH 267 >UniRef50_Q057D7 Methenyltetrahydrofolate cyclohydrolase n=4 Tax=Gammaproteobacteria RepID=FOLD_BUCCC Length = 284 Score = 290 bits (743), Expect = 4e-77, Method: Composition-based stats. Identities = 151/282 (53%), Positives = 208/282 (73%), Gaps = 3/282 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M KI+DG I++++ ++ +K++ R + PGLA++++G+NPAS IYV KR+AC + Sbjct: 1 METKILDGLKISKKIIKKIKKKIEKRKKKRKKIPGLAMIVIGNNPASLIYVNKKREACNQ 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 GF S + L E EL+ LI LN + IDGIL+QLPLP I+ +K++ I P KDV Sbjct: 61 AGFFSIYWHLSNQIEEIELINLIKKLNKNKCIDGILIQLPLPIKINYLKIITSIDPKKDV 120 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DGFHPYN+G LCQ P+ R CT +G++TLL++Y I+ GL AV+IG+SNIVG+PM MELL Sbjct: 121 DGFHPYNLGSLCQNNPQFRSCTSKGVITLLKKYKINIHGLYAVIIGSSNIVGKPMYMELL 180 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-- 238 LAGCT T+ ++ TKN++ +V+ ADL+++A+G+P F+ G WIK GAIVID+GIN L N Sbjct: 181 LAGCTVTIVNKNTKNIKTYVKKADLVVIAIGQPNFLYGHWIKLGAIVIDIGINYLYNKNK 240 Query: 239 -KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 K+VGDV F+ + + SYITPVPGGVGPMTV +L+ENTLQAC Sbjct: 241 YKIVGDVHFKSTSVKTSYITPVPGGVGPMTVVSLLENTLQAC 282 >UniRef50_Q54VK0 Methenyl tetrahydrofolate cyclohydrolase / NADP-dependent methylene H4F dehydrogenase n=1 Tax=Dictyostelium discoideum RepID=Q54VK0_DICDI Length = 440 Score = 289 bits (739), Expect = 9e-77, Method: Composition-based stats. Identities = 106/301 (35%), Positives = 161/301 (53%), Gaps = 20/301 (6%) Query: 6 IDGKTIAQQV---RSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 +DGK +A + + + + I P L V+ VG + + Y+ +KR CE+VG Sbjct: 86 LDGKLLASHIVSSKKSIKADTEDFIKNSGVTPNLVVIYVGDSKQIESYIKAKRTGCEDVG 145 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 F E +L++ I + D ++ GI+VQLPLP ++ +++ I P KDVDG Sbjct: 146 FKFTLDRFSSDIKEDQLIKKIKYHSEDPSVHGIIVQLPLPDNLNKDAIIQSIDPKKDVDG 205 Query: 123 FHPYNVGRLC-QRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 N+G++ + P PCTP GI+ +L+ Y I G N VV+G SN+VGR ++ L Sbjct: 206 LTSTNLGQIMISKKPLYIPCTPLGILEILKAYKIKVEGKNVVVLGRSNLVGRTIATILSQ 265 Query: 182 A---------GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGI 232 G T+ H+++KN + ADL+I A G PG I + +K G I+IDVGI Sbjct: 266 KDLTNPSIMNGANVTIIHKYSKNHLGSIRQADLIISATGVPGLIKKEDLKRGVILIDVGI 325 Query: 233 NRLENG------KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 + E+ K+VGD+ E A R+ TPVPGGVGP+TVA L+ N L++ + + Q Sbjct: 326 SFKEDSTKKSGYKMVGDIDPE-AYSRSIAYTPVPGGVGPLTVACLLRNVLRSAILQYRIQ 384 Query: 287 D 287 Sbjct: 385 S 385 >UniRef50_Q04FB7 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=Leuconostocaceae RepID=FOLD_OENOB Length = 285 Score = 287 bits (734), Expect = 4e-76, Method: Composition-based stats. Identities = 109/290 (37%), Positives = 156/290 (53%), Gaps = 9/290 (3%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 +I+DG+++++++ EV KV LA + N S++YV K + Sbjct: 1 MVQILDGRSVSKKILQEVKDKVA----KAGFPVKLATIYNEENEGSKMYVGMKIRRATFA 56 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G +S Y + + ++L L+ LN D++I GILVQ PL GID K+ I P KD D Sbjct: 57 GLISVEYKVDNSWKTDDILRLLSKLNMDSSICGILVQSPLGDGIDESKIFNAIDPLKDAD 116 Query: 122 GFHPYNVGRLCQR--APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 G +N G L + + P TP G+++LLE Y+ NA+V+G S + GRPMS+ L Sbjct: 117 GLSAFNQGLLFENAKENYIVPATPAGVISLLEAYHYQFAAKNALVVGRSVLFGRPMSVLL 176 Query: 180 LLAGCTTTVTHRFTK--NLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 T T+ H T LR + ADL++VA+GK + +K+ +VIDVG N+L N Sbjct: 177 TNRDMTVTLAHSKTPVDQLRQFAKRADLIVVAIGKANWFQFTDLKKDVVVIDVGANKL-N 235 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQD 287 G GDV FE S I+PVPGGVGPMT+ATLI++T V Q Sbjct: 236 GHATGDVDFEKVYPHVSQISPVPGGVGPMTIATLIKHTFDLAVFQQGEQK 285 >UniRef50_C5CI88 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=FOLD_KOSOT Length = 277 Score = 285 bits (731), Expect = 1e-75, Method: Composition-based stats. Identities = 85/282 (30%), Positives = 143/282 (50%), Gaps = 12/282 (4%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 ++DGK +A+ + +E+ + + P L + + +++ Y+ S K ++ Sbjct: 1 MGILLDGKPVAKMIYAEIKEWLGNLQEK---PPKLVLFCSEPDDSTKTYMNSIVKRGGKL 57 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G E E I LN + G+++ PL +D V+ + +KDV+ Sbjct: 58 GISVEICHAGENPVEE-----IKKLNESRDVAGVMIMHPL-KNVDEKLVVSALSLEKDVE 111 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G P N+G + P T ++ +L Y++ G + ++G S VG+P+SM +L Sbjct: 112 GRTPGNLGGIMTGDESFAPPTAEAVMEILRFYDVSLSGKDVTIVGRSTTVGKPLSMLMLK 171 Query: 182 AG--CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGK 239 G T T+ H TKNL ++ A++L+ AVG+ GFI + + + +I+IDVGIN L +GK Sbjct: 172 KGIDATVTICHSRTKNLVEKIKRANVLVSAVGRAGFITKEMVGKDSIIIDVGIN-LYDGK 230 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 +VGDV FE + ITPVPGGVG +T A L + + + Sbjct: 231 IVGDVDFEQVEPEVAAITPVPGGVGIVTTAILFRHFMVSSRR 272 >UniRef50_B5IEC2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein n=2 Tax=Aciduliprofundum boonei T469 RepID=B5IEC2_9EURY Length = 273 Score = 285 bits (729), Expect = 1e-75, Method: Composition-based stats. Identities = 116/278 (41%), Positives = 169/278 (60%), Gaps = 10/278 (3%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 II+ KT+A+++R ++ + + L ++VG + AS +Y S K ++GF Sbjct: 2 IIECKTLAKEIRENAKKEAK------GKKLWLHNIVVGGDEASLVYARSNLKLLRKLGFD 55 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + + L E SE ELL+LI LN D+++ GI+V PLP ID +KV I P KDVDG + Sbjct: 56 GKIHHL-EEASERELLDLIQALNEDDSVHGIMVNFPLPDNIDPMKVRSTISPIKDVDGIN 114 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 P N G+L L P TPR ++ +LER + G + ++I + +VG+P+S+ LL Sbjct: 115 PINYGKLLLGEEILTPNTPRAVIRILER-ETELRGKDVLIINRTPVVGKPLSLLLLNRDA 173 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+ H T+NL+ AD+++VAVGKP F+ D + EGAI+IDVGIN + NGK+VGD Sbjct: 174 TPTIAHSKTRNLKEKALEADVIVVAVGKPKFLKEDMVHEGAIIIDVGINVV-NGKIVGDA 232 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 F+ K+A ITPVPGGVG +T A LIEN ++A Sbjct: 233 DFDSIEKKAK-ITPVPGGVGTVTNACLIENLVKAAKLQ 269 >UniRef50_C1BVL5 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial n=2 Tax=Caligidae RepID=C1BVL5_9MAXI Length = 309 Score = 284 bits (728), Expect = 2e-75, Method: Composition-based stats. Identities = 114/299 (38%), Positives = 172/299 (57%), Gaps = 18/299 (6%) Query: 1 MAAKI---IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKA 57 MA I IDGK IA + + + +V++ ++ +P L +LVGS+PAS+IY+ K++A Sbjct: 1 MATSITRRIDGKAIANGILAGLKSEVESFVSKYGCSPKLVPILVGSDPASEIYLKRKQEA 60 Query: 58 CEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPD 117 ++G L E T+E ++ I LN D + GI+VQLPLP+ + +V E I+ Sbjct: 61 ASKIGIDCSIIRLHEKTTEESVISEICKLNQDPLVHGIIVQLPLPSEVREKEVCETINGL 120 Query: 118 KDVDGFHPYNVGRLCQR--APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPM 175 KDVD F ++G++ L PCTP + +++ ID G NAV++G S+ VG P+ Sbjct: 121 KDVDAFGLAHLGQIILNPLRSDLIPCTPLAVYKIIKSLEIDLSGKNAVILGRSHNVGMPI 180 Query: 176 SMELLLA------GCTTTVTHRFTK--NLRHHVENADLLIVAVGKPGFIPGDWIKEGAIV 227 ++ L TTT+ HR T L V+ AD+++ AVGKPG D IK+GA++ Sbjct: 181 ALLLAADHIKGGFNMTTTICHRATPPEELEVAVKRADVIVSAVGKPGLARRDMIKKGAVI 240 Query: 228 IDVGINRLENG----KVVGDVVFEDAAK-RASYITPVPGGVGPMTVATLIENTLQACVE 281 +DVGI R+++ K+ GDV AS++TPVPGGVGP TVA L+ NT++A Sbjct: 241 VDVGITRVKDKDDRYKLFGDVDPLVLMDGIASHMTPVPGGVGPCTVACLMHNTVRAAYN 299 >UniRef50_A4X776 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=Bacteria RepID=FOLD1_SALTO Length = 306 Score = 284 bits (727), Expect = 2e-75, Method: Composition-based stats. Identities = 100/281 (35%), Positives = 156/281 (55%), Gaps = 8/281 (2%) Query: 1 MA-AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACE 59 M+ A+ + G +A+Q+ +EVAQ+V A P LA VLVG + AS Y+ K++ Sbjct: 5 MSVARSLPGGPVAEQILAEVAQEVTQLRA-AGVTPALATVLVGDDDASVGYIRIKQRQAV 63 Query: 60 EVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKD 119 ++GF S LP + S+A+L ++ L+AD ++ G+LVQ P+P +D + ++ + P+KD Sbjct: 64 QLGFASPHVRLPASASQADLQAVVTQLSADTSVHGVLVQHPVPPHLDFDRAMQALDPEKD 123 Query: 120 VDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 VDG HP N+GRL P PCTP GI LL + + G VV+G +GRP++M L Sbjct: 124 VDGMHPVNLGRLALGLPGPTPCTPAGIEALLAYHEVPVAGREVVVLGRGATLGRPLAMVL 183 Query: 180 LLA----GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL 235 TV H + + A++++ A G PG + + ++ GA+V++ G+ R Sbjct: 184 AQKRPTANAAVTVVHTGVPDWPRYTRRAEIVVAAAGVPGLVRPEHLRPGAVVVNGGV-RY 242 Query: 236 ENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 +++ DV E A A +TP GGVGP TVA L N + Sbjct: 243 AGRRLLPDVD-ESCATVAGAMTPRVGGVGPTTVAMLFRNAV 282 >UniRef50_D1ITY4 Whole genome shotgun sequence of line PN40024, scaffold_5.assembly12x (Fragment) n=1 Tax=Vitis vinifera RepID=D1ITY4_VITVI Length = 271 Score = 284 bits (727), Expect = 3e-75, Method: Composition-based stats. Identities = 125/287 (43%), Positives = 160/287 (55%), Gaps = 44/287 (15%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A IIDGK IAQ +RSE+A++V+ + PGLAVV+VG+ SQ YV+ KRKAC EVG Sbjct: 9 ASIIDGKAIAQAIRSEIAEEVRHLSEKYGKVPGLAVVIVGNRKDSQSYVSMKRKACAEVG 68 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 S DLPE E+EL+ + LNA + GILVQLPLP I+ KVL I +KDVDG Sbjct: 69 IKSFDVDLPEQVLESELIGKVHELNALPDVHGILVQLPLPKHINEEKVLSEISLEKDVDG 128 Query: 123 FHPYNVGRLCQ--RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 FHP N+G+L R P PCTP+G + LL R I Sbjct: 129 FHPLNIGKLAMKGREPLFLPCTPKGCLELLSRSGISV----------------------- 165 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-- 238 K+ + +AD++I A G+ I G WIK GA VIDVG N + + Sbjct: 166 -------------KDPESIIRDADIVIAAAGQAMMIKGSWIKPGAAVIDVGTNAVNDPSK 212 Query: 239 ----KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 ++VGDV F++A K A ++TPVPGGVGPMTVA L++NTL Sbjct: 213 KSGYRLVGDVDFQEACKVAGWVTPVPGGVGPMTVAMLLKNTLDGAKR 259 >UniRef50_A0C3Q0 Chromosome undetermined scaffold_147, whole genome shotgun sequence n=2 Tax=Paramecium tetraurelia RepID=A0C3Q0_PARTE Length = 404 Score = 283 bits (725), Expect = 4e-75, Method: Composition-based stats. Identities = 106/283 (37%), Positives = 159/283 (56%), Gaps = 16/283 (5%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I +G +A + + + P L + LVG +PAS+ YV K KAC+E+ Sbjct: 119 IFNGNQLANTILKTLRITSE-------IKPKLGICLVGDSPASKSYVNRKLKACQEINVD 171 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + ++ E + +L++ I +N D GILVQLPLP+ ++ + ++ I +KDVD H Sbjct: 172 AEVFNFSENVGQEQLIKHIQQMNHD----GILVQLPLPSHLNKLDIIHSIPYEKDVDCLH 227 Query: 125 PYNVGRLCQRAP--RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 +N+ R+ + PCTP ++ +L+ Y+++ G +IG S +VG P+S+ L Sbjct: 228 MHNLQRILVYGELCEMLPCTPAAVLQILDYYDVNVIGKKVTMIGRSFLVGLPLSLLLQKR 287 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE-NGKVV 241 T TV HR T NL H+ NAD++I A G P + +K+GAIVIDVGI++ E GK+V Sbjct: 288 NATVTVCHRETLNLDQHIMNADIVISAAGHPKLVRN--VKQGAIVIDVGISQGEKKGKIV 345 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 GDV F+ +AS ITPVPGGVGPMTV L+ N + Sbjct: 346 GDVDFDVVKNQASLITPVPGGVGPMTVCMLMRNLCNIWKKKQG 388 >UniRef50_B9CK25 Bifunctional protein FolD n=1 Tax=Atopobium rimae ATCC 49626 RepID=B9CK25_9ACTN Length = 285 Score = 282 bits (722), Expect = 1e-74, Method: Composition-based stats. Identities = 85/282 (30%), Positives = 134/282 (47%), Gaps = 3/282 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A+ + G +A + ++ + A P LA++ +G Y + K E++ Sbjct: 1 MAEELRGAPVAAALTEALSVRAAALADR-GVTPTLAILRLGERSDDLAYERAALKRAEKI 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G R L S+ ++ E I +++D I L P P I+ + P KDVD Sbjct: 60 GIAVRQTVLSRNASQHDVDETIRDISSDPHIHACLPLRPFPKTINEAGAFALLSPSKDVD 119 Query: 122 GFH-PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 + L R+ L PCT ++ +L+ Y I+ G A V+G SN++GRP++ L Sbjct: 120 CVTDSMLLATLSGRSCALAPCTAEAVIAILDHYGIEIAGARAAVVGRSNVIGRPVAALLT 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG-K 239 + T T+ H T +L A++L+VA G+ I ++ G VIDVGIN E K Sbjct: 180 MRDATVTLCHSRTVDLPSVTCEAEILVVAAGRARMIDSGYVAPGQTVIDVGINWDEASQK 239 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 +VGDV E + TPVPGGVG +T A L ++ ++A Sbjct: 240 LVGDVDAEAIKDTVAAYTPVPGGVGSVTTAILAKHVIEAAER 281 >UniRef50_A0DMT9 Chromosome undetermined scaffold_57, whole genome shotgun sequence n=2 Tax=Paramecium tetraurelia RepID=A0DMT9_PARTE Length = 309 Score = 282 bits (722), Expect = 1e-74, Method: Composition-based stats. Identities = 106/252 (42%), Positives = 145/252 (57%), Gaps = 4/252 (1%) Query: 33 APGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTI 92 PGLA++ VG+NP+S YV K CEE Y PET S+ E++ I +LN +I Sbjct: 36 RPGLAIIQVGNNPSSLTYVRKKIALCEEHQIHHELYHFPETISQKEIVHRIKSLNQKGSI 95 Query: 93 DGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQR--APRLRPCTPRGIVTLL 150 DGILVQLPLP + +++ I +KD+D H N L Q + PCTP ++ +L Sbjct: 96 DGILVQLPLPPHLSRLEISNEIKLNKDIDCLHMANFQNLLQNGEDNDIIPCTPAAVLHIL 155 Query: 151 ERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAV 210 + NID N VIG S +VG P+S+ LL T+ H T ++ HVE AD++I Sbjct: 156 DTQNIDVRNQNVTVIGRSQLVGFPLSVLLLKRNARVTICHSET-TVQEHVEKADIVISCA 214 Query: 211 GKPGFIPGDWIKEGAIVIDVGINRLE-NGKVVGDVVFEDAAKRASYITPVPGGVGPMTVA 269 G + G+WIK GA VIDVGI R+ ++VGD+ F+ A R S+ITPVPGGVGP+TV+ Sbjct: 215 GHKELVKGEWIKNGAKVIDVGITRIPGTNQIVGDIEFQKALPRVSFITPVPGGVGPLTVS 274 Query: 270 TLIENTLQACVE 281 L N + Sbjct: 275 MLFRNLYRVWCR 286 >UniRef50_Q0AWX5 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Syntrophomonas wolfei subsp. wolfei str. Goettingen RepID=FOLD2_SYNWW Length = 272 Score = 282 bits (722), Expect = 1e-74, Method: Composition-based stats. Identities = 105/277 (37%), Positives = 158/277 (57%), Gaps = 7/277 (2%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 +I GK I +Q++ V Q + GLA++ VG +P+S YV RK EE G Sbjct: 2 LIYGKDIREQIKERVRQSAEEVKM------GLAIIRVGDDPSSMAYVRGIRKFAEETGVK 55 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 +LP+ E ELL+ I LN + I GI++Q PLPA ++ ++ I DKDV+G H Sbjct: 56 VEIVNLPDAVGERELLKTIGDLNNSSEITGIMLQTPLPASLNASHLVNAIDFDKDVEGIH 115 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 YN+G+L + +RPCTP+ ++++L+ ++I G +IG S VG P+++ + Sbjct: 116 NYNLGKLISKEEGVRPCTPKAVISMLKAHDILIEGQKVTIIGRSMTVGSPLALMMTAENA 175 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T TV H T+NL+ AD+L+ AVGK F+ D + + +VIDVGIN ENGK++GDV Sbjct: 176 TVTVCHTRTRNLKEEALRADILVAAVGKREFVTADMVHKDMVVIDVGINFDENGKMLGDV 235 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 E+A + VPGG+G +TVA L +N + Sbjct: 236 -HEEARNHCRLASAVPGGIGVITVAELFDNLRILSQK 271 >UniRef50_B5Y9D1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=FOLD_COPPD Length = 273 Score = 279 bits (713), Expect = 1e-73, Method: Composition-based stats. Identities = 100/282 (35%), Positives = 146/282 (51%), Gaps = 12/282 (4%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A I+ GK +A + E+ + G+ + Y++ KA + + Sbjct: 1 MALIMKGKPVADAIYEELQPMTSLNLTLGIIKYK--------GSDAGGYLSGLSKAAQRL 52 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 + E EL + + + D+ + GIL+ P P + + + I P+KDVD Sbjct: 53 NVQ---LRVNEVEQFQELTQSVVVMGKDSQVHGILLLKPFPKEWNFRQASDLIPPEKDVD 109 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNI-DTFGLNAVVIGASNIVGRPMSMELL 180 HP N+G+L Q L P TP+ ++++L+ YN+ G +A+VIG S VG P ++L+ Sbjct: 110 ALHPVNLGKLAQGRGNLVPATPQAVLSILDFYNVLPLEGASALVIGRSEAVGLPAFLQLM 169 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T TV H TK+L ADL++VAVGKP F+ D +KEGA+VIDVG N LE+GKV Sbjct: 170 QRNATVTVAHSRTKDLPSLSRQADLVVVAVGKPNFLTKDHVKEGAVVIDVGTNVLEDGKV 229 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 VGDV E+ ITPVPGGVG +T A L +N E Sbjct: 230 VGDVDRENVEPLVRAITPVPGGVGSVTTACLFKNLFLCYQEQ 271 >UniRef50_C8WN84 Tetrahydrofolate dehydrogenase/cyclohydrolase n=1 Tax=Eggerthella lenta DSM 2243 RepID=C8WN84_EGGLE Length = 289 Score = 277 bits (709), Expect = 3e-73, Method: Composition-based stats. Identities = 85/276 (30%), Positives = 139/276 (50%), Gaps = 2/276 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A+++ GK + + ++ +++A P LA+V VG P Y + RK E + Sbjct: 1 MAELLKGKPVVDSMALDLRARIEAL-GRAKVVPALALVRVGQRPDDLSYERTARKRAESL 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G R Y+L E +A + I +N D + G L+ PLP+ +D + E + P KD+D Sbjct: 60 GIAIRPYELDEFAPQAAIEAAIHEVNRDENVHGCLLFRPLPSFVDESHMCELLDPKKDID 119 Query: 122 GFHPYNVGRLC-QRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 G ++ + P T + LL+ Y + G + VV+G S +VG+P+SM LL Sbjct: 120 GITLASLASVFTDGHAGYPPATAAACIQLLDHYQVPLQGKHVVVVGRSLVVGKPVSMMLL 179 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 + T+ H T+NL + +AD++I A G+ + G V+DVGIN G + Sbjct: 180 RRNASVTICHSKTENLADIMRSADVVICATGRARTFGAQFFGPGQTVLDVGINFDTQGNL 239 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 GDV F + + ITPVPGG+G +T + + +T+ Sbjct: 240 CGDVDFAEVEPVVAAITPVPGGIGTVTTSVTMAHTV 275 >UniRef50_D2W298 Predicted protein n=2 Tax=Naegleria gruberi RepID=D2W298_NAEGR Length = 319 Score = 277 bits (708), Expect = 4e-73, Method: Composition-based stats. Identities = 115/303 (37%), Positives = 179/303 (59%), Gaps = 24/303 (7%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGL----RAPGLAVVLVGSNPASQIYVASKRKACEE 60 +I+G IA +++ E+ + ++ + R PGLAVV+VGS S YV K++AC E Sbjct: 12 LINGLEIAAEIKEEIKRDIERIVEKQKGGQVRRPGLAVVMVGSRKDSLTYVQRKQEACAE 71 Query: 61 VGFVSRSYDLPET--TSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDK 118 +G S + ++ ++++ I NAD+ + GILVQLPLP+ ++ K+LE I P K Sbjct: 72 LGIESFKTHFEDDQSVTDEDVIKTIQQYNADDRVHGILVQLPLPSHLNEEKILESISPAK 131 Query: 119 DVDGFHPYNV------GRLCQRAPRLRPCTPRGIVTLLERY----NIDTFGLNAVVIGAS 168 DVDG ++ GR PCTP GI+ ++ R N++ GL++VV+GAS Sbjct: 132 DVDGLTQFSFGLISMKGRKLVDGINFVPCTPLGIMEMIRRTAQKLNMNLEGLDSVVVGAS 191 Query: 169 NIVGRPMSMELLLA-GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIV 227 NIVG P ++ LL + + H ++N+ + AD+L+V G I +WIK+GAIV Sbjct: 192 NIVGIPTALVLLNQLQTSVQLLHIKSQNIPEKISKADILVVCCGCAEIIKPEWIKKGAIV 251 Query: 228 IDVGINRLENG------KVVGDVVFED-AAKRASYITPVPGGVGPMTVATLIENTLQACV 280 IDVG+ +E+ ++VGDV+F+D KRAS TPVPGGVGP+T+A+L++NT + + Sbjct: 252 IDVGLTPVEDKTQERGFRLVGDVLFDDNLKKRASAATPVPGGVGPVTIASLMKNTYHSFL 311 Query: 281 EYH 283 + Sbjct: 312 SKN 314 >UniRef50_C8WUM8 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WUM8_ALIAD Length = 285 Score = 277 bits (708), Expect = 4e-73, Method: Composition-based stats. Identities = 85/281 (30%), Positives = 142/281 (50%), Gaps = 2/281 (0%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 K + G+ +A+ + +V + V+ + P L +L + A+ +Y K++ E + Sbjct: 1 MPKPLLGRPVAKALSHDVRKTVETWKSR-GVQPKLVTLLANDDHAASVYANQKKRIAERL 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G +LP+ + ++ I LN D ++ GI++++PL +D +V+ IH KDVD Sbjct: 60 GIQCDVIELPQQSDTEAIVRQIQALNDDPSVHGIMIEMPLAPSVDVQRVVGAIHALKDVD 119 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 G P + L P TP + LL+ Y G + ++G VG P+ L+ Sbjct: 120 GLSPCHSFAKPTPEAALYPATPLACIRLLKHYGYQLKGADVTLVGCGQTVGMPLLHLLIA 179 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 G T H T+++R H+ ++++ IVAVGK G + D + +G V+DVGI++ ENG V Sbjct: 180 EGATVAACHEHTRDVRAHLRDSEIAIVAVGKGGLLGPDMVHDGLTVVDVGISQGENGDVQ 239 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 GD+ E AA + TP PGGVG +T + N + A Sbjct: 240 GDLAPEAAA-KTKAYTPTPGGVGAVTTVQIFANLMHAMELQ 279 >UniRef50_Q2JCX4 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=Frankia RepID=FOLD1_FRASC Length = 276 Score = 275 bits (705), Expect = 9e-73, Method: Composition-based stats. Identities = 100/277 (36%), Positives = 149/277 (53%), Gaps = 4/277 (1%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +++DG+++A ++ V + + A P LAVVL ++PA+ Y + +VG Sbjct: 2 RMLDGRSMAAEIGRYVVDEAERLAA-AGVTPTLAVVLPTADPAAYSYAEIIERTAGKVGV 60 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 ++ A +L+ IDT+ AD T+ GI+VQ PLP G+ + +V E I KDVDG Sbjct: 61 HCVLHE--PKGEPAAILDTIDTVAADPTVHGIIVQTPLPGGLTSREVGEHIPTAKDVDGM 118 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 +P ++GRL P P T +V +L R I G VIG +VG+P+S+ LL Sbjct: 119 NPSSLGRLALGLPSFAPATAAAVVEILTRARIPMSGARVCVIGRGPVVGKPVSLLLLAED 178 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T T+ H TK L AD+++ A G P + +++ GA VIDVG E G+ VGD Sbjct: 179 ATVTICHSRTKGLVSIAHEADIIVSATGHPRLVGAGFVRPGAAVIDVGTVVTETGQ-VGD 237 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 V + A +TPVPGGVGP+T L+ NT++A Sbjct: 238 VDAAAVSSVAGALTPVPGGVGPVTTMLLLRNTIRAAR 274 >UniRef50_Q1AVQ0 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Rubrobacter xylanophilus DSM 9941 RepID=FOLD2_RUBXD Length = 320 Score = 275 bits (704), Expect = 1e-72, Method: Composition-based stats. Identities = 110/298 (36%), Positives = 151/298 (50%), Gaps = 20/298 (6%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A++IDG+ IA +++ VA +V+ A G+R PGLA VLVG + A++ Y E Sbjct: 1 MGARVIDGRPIAGELKKRVASEVEGLAARGVR-PGLATVLVGEDYAARAYERRVGGLAAE 59 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G LP EA++L ++ LNAD + GILV PLP I V + P KD+ Sbjct: 60 LGCRYVCERLPREAEEADVLAVVGKLNADPRVSGILVLRPLPGHISEPAVFSALDPLKDI 119 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGL---------NAVVIGASNIV 171 + HP N G L PR P TP LL+RY ++ G VV+G SN V Sbjct: 120 EAVHPVNAGLLALGRPRYVPSTPAACFYLLDRY-LERSGRPPEEFYPRSTVVVVGRSNNV 178 Query: 172 GRPMSMELLLAGCTTTVTHR---FTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVI 228 G+P G LR H AD LIVA G G I +++EG I + Sbjct: 179 GKPAVSLGFARGAAVISCDANAYRAGRLREHTLKADALIVAAGVAGLIDESYVREGVIAV 238 Query: 229 DVGINRLENGK------VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 DVGIN + + +VGD+ F A++A +TPVPGGVGP+T L++NT+ A Sbjct: 239 DVGINPVADPGGSGRTLLVGDLDFGSVARKAEALTPVPGGVGPITDVWLLKNTVAAGR 296 >UniRef50_B7QFP4 C1-tetrahydrofolate synthase, putative n=1 Tax=Ixodes scapularis RepID=B7QFP4_IXOSC Length = 297 Score = 275 bits (703), Expect = 1e-72, Method: Composition-based stats. Identities = 107/256 (41%), Positives = 146/256 (57%), Gaps = 11/256 (4%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 ++IDGK IA ++ +E+ + + + G R P L VLVG + S +YV +K KA E G Sbjct: 32 EVIDGKRIANEIETEIRSAINSDLVHGGRRPHLCAVLVGDDEGSAVYVKNKIKASERTGI 91 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S + LP +T++ +LL LI LN +DGILVQLPLP I+ + + P KDVDGF Sbjct: 92 TSENIHLPSSTTQTDLLSLIKKLNESKFVDGILVQLPLPRHIEESVICNSVLPSKDVDGF 151 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA- 182 H +GRLC L PCTP IV +L+R ++T G + VV G S IVG P+S+ L A Sbjct: 152 HALQMGRLCLNMDSLAPCTPLAIVEILQRTGVNTTGKHIVVCGRSTIVGLPISIMLGSAR 211 Query: 183 ---GCTTTVTHRFT--KNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN 237 T + H T +LR V AD+++ A G PG I + +K G VIDVGI R+ + Sbjct: 212 SYGNATVSCCHSHTSPSDLRALVGMADIVVTATGVPGLIMANMVKHGVCVIDVGITRVHD 271 Query: 238 G-----KVVGDVVFED 248 K+VGDV FE Sbjct: 272 SVTGKTKLVGDVDFEG 287 >UniRef50_Q160C0 Methenyltetrahydrofolate cyclohydrolase n=9 Tax=Alphaproteobacteria RepID=FOLD3_ROSDO Length = 290 Score = 275 bits (703), Expect = 2e-72, Method: Composition-based stats. Identities = 93/283 (32%), Positives = 151/283 (53%), Gaps = 8/283 (2%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +++ GK + R + ++V++ R L + +G P +YV ++ +A G Sbjct: 5 RLLMGKPV----RERILEEVRSVTEKVDRIGKLVSISIGDVPEVAVYVRNQARAASTAGL 60 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 ++ E +I +N D + GI++Q P+P I+ + IHP KDV+G Sbjct: 61 PFDQEFWGADVTQDECKAMIQKMNDDPEVLGIILQRPVPDHINVRSLQSAIHPLKDVEGM 120 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 +P ++G + + PCT V L+ + GL V++G S IVG+P +M L+ G Sbjct: 121 NPASIGNIVYNDVAMAPCTAAAAVELIRETGLKLEGLEVVMVGHSEIVGKPAAMMLMAEG 180 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE----NGK 239 T TV H T+++ H AD+++VAVGK I D +K GA VID+GIN++ N + Sbjct: 181 ATVTVCHHLTRSVAMHSRRADVIVVAVGKAHLIGADMVKPGAAVIDIGINQITEADGNTR 240 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 +VGDV + + A ++TPVPGGVGP+TVA L+ N ++A Sbjct: 241 IVGDVDTDAVKEIAGWVTPVPGGVGPVTVAILMRNAVRAHERQ 283 >UniRef50_UPI00003C8447 methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI00003C8447 Length = 281 Score = 274 bits (701), Expect = 3e-72, Method: Composition-based stats. Identities = 95/282 (33%), Positives = 151/282 (53%), Gaps = 4/282 (1%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 ++DGK +A + + +++ I P L ++ VG++PAS IY SK K ++G Sbjct: 2 LLDGKVVASEKMERLKSEIKGIIEKYGIEPELKLIQVGNDPASTIYANSKIKRGTKLGIN 61 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + +L++ I NA++ I+GI+V+ PLP ++ +V++ I KD DG Sbjct: 62 VTLEKFD-NITMGKLVDYIKDANANSRINGIMVESPLPPSLNFQEVVDNISFYKDTDGMT 120 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 +N G L + + P T R +V +LE Y I NA +I S +VGRP++M LL Sbjct: 121 SFNQGNLYTKNEMIAPATARAVVDILEYYKIQPG--NACIINRSAVVGRPLAMLLLNRDY 178 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T T+ H T +++ ++L+VA+GKP +I ++ + VIDVGIN N K+ GDV Sbjct: 179 TVTLCHSKTVDIKRIARENNVLVVAIGKPDYIDESYVTSESTVIDVGINYSGN-KISGDV 237 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 F+ + +A ITPVPGGVG +T + EN L + Sbjct: 238 NFDSVSNKAKNITPVPGGVGIVTATDIFENFLNGLKYQIKEK 279 >UniRef50_Q86F84 Clone ZZD1003 mRNA sequence n=2 Tax=Schistosoma japonicum RepID=Q86F84_SCHJA Length = 332 Score = 272 bits (697), Expect = 7e-72, Method: Composition-based stats. Identities = 94/299 (31%), Positives = 147/299 (49%), Gaps = 22/299 (7%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 I+ G+ +AQ V ++ V ++ P L V+ VG P S++Y+ K K ++ G Sbjct: 4 GIILYGRQVAQAVGHKIKLDVALLKSSFDVYPKLVVIEVGELPQSKLYIKQKFKFAKKYG 63 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPA--GIDNVKVLERIHPDKDV 120 + LP SE+ LL+ + LNAD+++ GI +QLP + I+ L + KDV Sbjct: 64 ILLSHMRLPSHISESLLLDYVYKLNADSSVHGITLQLPFDSDTNINVTNSLNAVATHKDV 123 Query: 121 DGFHPYN------------VGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGAS 168 +G + YN + RL + CT L+ N G V+IG Sbjct: 124 EGLNSYNTALLSVVIYSATLRRLKTKTYSYT-CTAAACYALIRHVNFPISGSRCVIIGRG 182 Query: 169 NIVGRPMSMELLLA-GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIV 227 +VG P + L + G T H + N+ + D++I VG PG I GDW++ GA+V Sbjct: 183 RLVGAPTAELLSGSCGATVIQCHLQSANIDEEINRGDIIISGVGHPGLIKGDWVRPGALV 242 Query: 228 IDVGINRLEN------GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 ID G + + + + GDV F A ++A +ITPVPGGVGP+++A L NT+ + Sbjct: 243 IDCGYSVMNDPQNPSKSRCFGDVEFNTALEKAKWITPVPGGVGPVSIAMLFRNTVNSAQ 301 >UniRef50_B5RQK8 Methylenetetrahydrofolate dehydrogenase n=2 Tax=Borrelia RepID=B5RQK8_BORRA Length = 313 Score = 272 bits (696), Expect = 1e-71, Method: Composition-based stats. Identities = 104/285 (36%), Positives = 151/285 (52%), Gaps = 8/285 (2%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 + DGK A + + + + + L V+L ++PAS++YV+ K + +E+G Sbjct: 16 VFDGKIFANRYYLLLKEFL--IYHNLVSKISLKVILANNSPASELYVSVKERVSKEIGIN 73 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 L E + ++L LI+ N ++ DGI+VQLPL ID +L I KDVDG Sbjct: 74 FNVIRLSENLHQDDILRLIEIENTNDYTDGIIVQLPLANKIDVNMILNSILSIKDVDGLS 133 Query: 125 PYNVGRLCQRAP-RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA- 182 N+G+L PCT I+ +L Y I+ G VVIG S +VGR +S+ L Sbjct: 134 FVNLGKLVSGDKRGFIPCTALAILKILFDYKIEISGKTVVVIGRSLLVGRAISILLSCKP 193 Query: 183 -GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE---NG 238 T V H T NL +V+ AD++I AVGKP I I VID+GI+R++ + Sbjct: 194 YNATVIVCHSKTVNLDFYVKQADVIISAVGKPKLIDASMIVGHPYVIDIGISRVDVNNSS 253 Query: 239 KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 +VGDV FE R +ITPV GGVGP+TV L+ NT++A + Sbjct: 254 VLVGDVDFEAVKDRVRFITPVIGGVGPVTVLMLMFNTIKAYLIRR 298 >UniRef50_C1MLD7 5,10-methylene-tetrahydrofolate dehydrogenase/cyclohydrolase n=1 Tax=Micromonas pusilla CCMP1545 RepID=C1MLD7_9CHLO Length = 405 Score = 272 bits (695), Expect = 1e-71, Method: Composition-based stats. Identities = 116/353 (32%), Positives = 164/353 (46%), Gaps = 75/353 (21%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A+ +DG+ A + +++ + R PGLA ++VG+ P S +YV K +AC++ G Sbjct: 56 ARHLDGRQHAIRWM----REIAISASRNPRPPGLAAIVVGNRPDSLLYVRRKGEACKKTG 111 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 LP + ++ +++ LN+D IDGILVQLP+P I K+LE I P+KDVDG Sbjct: 112 IHFYLIHLPGDIRQGKVRQILRRLNSDKNIDGILVQLPMPPQITENKLLECISPEKDVDG 171 Query: 123 FHPYNVGRLCQR---APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 HP NVGRL R P PC P G + LL R I+ VIG SNIVG P+S L Sbjct: 172 LHPKNVGRLSARGTWRPVFMPCAPLGCMELLWREKINVKKKAVTVIGDSNIVGMPLSWLL 231 Query: 180 LLAGC-TTTVTHRFT------------------------KNLRHHVENADLLIVAVGKPG 214 AG + T+ H + H + AD++I AVG G Sbjct: 232 RDAGASSVTILHSRAIWFLDKFSTAGSDDSQLCEDKPLQAQILHSLCEADVVIAAVGSVG 291 Query: 215 FIPGDWIKEGAIVIDVGINRLEN------------------------------------- 237 + +WIKEGA V+D+GIN + + Sbjct: 292 LVKREWIKEGATVVDIGINAVPDCHESVIFTGISPQKDCVNVCSSVTAMQRDAQQSFRSV 351 Query: 238 ------GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHD 284 K++GDV E+ + A +T VPGG GPMT+A L+ NT + H Sbjct: 352 PQPLRNFKILGDVAAEEVSHVAGAMTSVPGGAGPMTIAALLSNTCLSASRKHR 404 >UniRef50_C4QA37 Formate-tetrahydrofolate ligase, putative n=1 Tax=Schistosoma mansoni RepID=C4QA37_SCHMA Length = 335 Score = 270 bits (691), Expect = 4e-71, Method: Composition-based stats. Identities = 98/303 (32%), Positives = 148/303 (48%), Gaps = 23/303 (7%) Query: 1 MAAK--IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKAC 58 M +K + G+ IAQ V ++ V + +P L VV VG+ P S++Y+ K K Sbjct: 1 MMSKGITLCGQQIAQTVGQKIISDVAYLKSNFNISPKLVVVEVGNLPQSKLYIEQKSKFA 60 Query: 59 EEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPL--PAGIDNVKVLERIHP 116 ++ G + P E+ LL+ + LN+D+++ GI +QLP + I+ L + Sbjct: 61 KKYGILLSHMRFPSHIPESVLLDYVYKLNSDSSVHGITLQLPFDSDSNINVTNPLNAVAT 120 Query: 117 DKDVDGFHPYNVGRLCQRA------------PRLRPCTPRGIVTLLERYNIDTFGLNAVV 164 KDV+G +PYN L + PCT + N G V+ Sbjct: 121 LKDVEGLNPYNTAVLSRGDILCPYCENVKQQHVHIPCTAAACYAFIRHVNFPIIGSRCVI 180 Query: 165 IGASNIVGRPMSMELLLA-GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKE 223 IG +VG P + L + G T H + N+ + D++I AVG P I G+WIK Sbjct: 181 IGGGRLVGAPTADLLSRSCGATVIQCHIQSNNINEEINRGDVVISAVGHPRLIKGEWIKP 240 Query: 224 GAIVIDVGINRLEN------GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 GA+VID G + L + + VGDV FE A + A +ITPVPGGVGP+++A L NT+ Sbjct: 241 GALVIDCGYSVLNDPRNPNKSRCVGDVEFETAIENAKWITPVPGGVGPVSIAMLFRNTVN 300 Query: 278 ACV 280 + Sbjct: 301 SAK 303 >UniRef50_Q6L046 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Picrophilus torridus RepID=FOLD_PICTO Length = 276 Score = 268 bits (686), Expect = 1e-70, Method: Composition-based stats. Identities = 91/278 (32%), Positives = 148/278 (53%), Gaps = 6/278 (2%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 IIDG I++ + +++ P + ++L+G++ S +Y +K + ++G Sbjct: 2 IIDGVKISETKMERLKNEIEKIK-NTGINPKMKIILIGNDYGSVVYSKAKMRRGSKLGID 60 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + S +L++L+ + + I GI+++ P+P GI+ V+ I KDVDG Sbjct: 61 VDLDRYD-SISREDLIKLLKRYSQSDDIHGIMIETPVP-GINYYDVVNEIPFYKDVDGMT 118 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGC 184 YN+G L + + P T R +V +L+ I+ N +I S +VGRP+SM LL Sbjct: 119 SYNLGNLYLKNEFIAPATARAVVDILDY--INIKSGNVAIINRSPVVGRPLSMMLLNRDF 176 Query: 185 TTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDV 244 T TV H T N+ ++D+++VAVGKP F+ ++ + I+IDVGIN L NGK GD Sbjct: 177 TVTVCHSRTVNINEITRSSDIVVVAVGKPNFLDRSYVSDKNIIIDVGINYL-NGKTCGDA 235 Query: 245 VFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 +E+ + ITPVPGGVGP+T + EN + Sbjct: 236 DYENIKDYVNAITPVPGGVGPVTATDIFENFINGLKYQ 273 >UniRef50_Q4A6B1 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Mycoplasma synoviae 53 RepID=FOLD_MYCS5 Length = 278 Score = 267 bits (682), Expect = 4e-70, Method: Composition-based stats. Identities = 92/283 (32%), Positives = 148/283 (52%), Gaps = 12/283 (4%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 KI+ G+ A+Q ++ +++ R LA++ VG S YV K K +E+G Sbjct: 2 KILSGREKAEQDLKQLKKELDEL--NLNRPIKLAIIQVGDKMESNRYVEQKLKKAKEIGI 59 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 ++ + E ++ LL +D +N + DGIL+QLPLP + +L+ + +KD+DG Sbjct: 60 EAKCFKFDENITQKRLLLAMDEINEN--WDGILIQLPLPKHLPKEVILDAVPYEKDIDGL 117 Query: 124 HPYNVGRLCQ----RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 N L P R ++ L+E + I+ V+G S++VG+P++ L Sbjct: 118 SHRNEFILYNEKNSDDKFFVPAAARAVLELIEHHEINYKKKKVAVVGRSHLVGKPVAHIL 177 Query: 180 LLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLEN-- 237 G + + T V +AD++IVA+G P +I + IK+GAI+IDVG N +N Sbjct: 178 KRRGASVSTFDENTP--IKLVASADIVIVAIGVPKYIKAENIKQGAIIIDVGTNYDQNDP 235 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 + GDV E +AS ITPVPGGVGP+TV L++N ++ Sbjct: 236 SVIFGDVDHESVKTKASAITPVPGGVGPLTVVCLLKNLVEIYK 278 >UniRef50_Q8EV80 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Mycoplasma penetrans RepID=FOLD_MYCPE Length = 282 Score = 265 bits (678), Expect = 1e-69, Method: Composition-based stats. Identities = 98/288 (34%), Positives = 155/288 (53%), Gaps = 9/288 (3%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M ID IA + + ++ + P +A+V + + AS YV+ K K E Sbjct: 1 MIVNCID---IANNILDKFKSDLEKLKKKKII-PHMAIVKINDDAASDKYVSIKLKKAAE 56 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G + ++ +L++ I LN D++IDG ++QLPLP G D+ + E I +KD+ Sbjct: 57 LGVKTTLIS-EGIKTQDDLIKQIHILNNDDSIDGYIIQLPLPKGFDSNVICEHIDVNKDI 115 Query: 121 DGFHPYNVGRLCQRAPRLRP--CTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSME 178 DG + + R + P CT GI+ +L++ N G +AV+I S IVG+P+ Sbjct: 116 DGLSSFAISRNLANSNLFHPKPCTANGIIEILKQSNYSIEGKHAVIINRSMIVGKPLIGL 175 Query: 179 LLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 L T TV H T+NL+ + AD+++VA+GKP F+ D + A VID GI+ + +G Sbjct: 176 FLENNATVTVCHTKTQNLKEMTKTADIVVVAIGKPDFLTKDMVNPNAFVIDAGISVV-DG 234 Query: 239 KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 KVVGD +D + YITPVP GVG +TVA + +N + E ++ + Sbjct: 235 KVVGDAA-KDLQEYVKYITPVPNGVGRLTVAMIFKNLMDLVKEKYNER 281 >UniRef50_A7HMQ2 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Fervidobacterium nodosum Rt17-B1 RepID=FOLD_FERNB Length = 272 Score = 265 bits (677), Expect = 2e-69, Method: Composition-based stats. Identities = 87/273 (31%), Positives = 144/273 (52%), Gaps = 13/273 (4%) Query: 10 TIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYD 69 + + + ++V + P L V + ++ Y+ S+ K + G Y+ Sbjct: 7 PLYSSMVENIKERVSKL----SKPPKLVAVTCQPDSSTLAYLRSQEKQAKRFGIDFAVYE 62 Query: 70 LPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVG 129 P+ +L L+ L+AD +++GI + PLP+ I + + I PDKD++G HP N+G Sbjct: 63 APKAM---DLKILLPKLSADGSVNGIFLTHPLPSDISEYEAVSLISPDKDIEGRHPINLG 119 Query: 130 RLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG--CTTT 187 + P PCT ++ ++ Y + G VIG S VG+P++M LL G T T Sbjct: 120 NILYDKPVFPPCTAEAVLRIIN-YLTNPSGKKIAVIGRSVTVGKPLAMLLLQKGIDATVT 178 Query: 188 VTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFE 247 + H TK++ +N+D+++VA+GK D+ K G IVIDVGIN + ++VGDV Sbjct: 179 ICHSRTKDIAEITKNSDIVVVAIGKAKMFGKDYFKPGTIVIDVGINVEGD-EIVGDVD-P 236 Query: 248 DAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 ++ +TPVPGGVG +T L+E+T++A Sbjct: 237 SVSEICE-LTPVPGGVGRITTLVLMEHTVKAAE 268 >UniRef50_Q979W3 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Thermoplasma RepID=FOLD_THEVO Length = 281 Score = 263 bits (672), Expect = 6e-69, Method: Composition-based stats. Identities = 93/285 (32%), Positives = 164/285 (57%), Gaps = 8/285 (2%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 MA K++ G+ IA++ E+ ++++ +P L ++ VG+ A+ IY +K K ++ Sbjct: 1 MAVKLLKGEEIAEKKAEELKERIEKM----GVSPRLVLLQVGNYSAATIYARAKIKRGKK 56 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G E ++ EL+ I+ L+AD ++GI+V+ PLP ID +++ I KDV Sbjct: 57 IGADVVLEKY-EDLTKQELVRRIEELSADKDVNGIMVENPLPKTIDYYDIVKSIPYYKDV 115 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 D PYN G + L P T +V +L+ Y + A +I S +VGRP+SM +L Sbjct: 116 DALSPYNQGSIAINREFLVPATAMAVVDILKYYGYEKT--TATIINRSPVVGRPLSMMML 173 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T ++ H T ++R + + +++VAVG+PGF+ ++ E ++VIDVGIN +++ KV Sbjct: 174 NRDYTVSICHSKTPDIRSIAKASKIIVVAVGRPGFLDDTYVTESSVVIDVGINYVQD-KV 232 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDP 285 +GD+ F+ +++ +TPVPGGVGP+T ++ N ++A + Sbjct: 233 IGDIDFDKVSEKVEAVTPVPGGVGPITATNILSNLVKAAEYQSNT 277 >UniRef50_D1VQM8 Methylenetetrahydrofolate dehydrogenase (NADP(+)) n=1 Tax=Frankia sp. EuI1c RepID=D1VQM8_9ACTO Length = 277 Score = 262 bits (669), Expect = 1e-68, Method: Composition-based stats. Identities = 103/280 (36%), Positives = 150/280 (53%), Gaps = 4/280 (1%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +++DG+ +A ++ V +V +A P LAVVL G + A+ + + VG Sbjct: 2 RLLDGRAMAAEIGRHVVDEVA-LLAEAGVTPTLAVVLPGDDRAALSFARVIEQTAGRVGV 60 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + + L EL E + L AD + GIL Q PLPAG+ +V RI KDVDG Sbjct: 61 ACQRHQLSG--KPDELTETLGRLAADPAVHGILAQTPLPAGMTADEVGARIPASKDVDGM 118 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 +P ++GRL P P T +V +L R ++ G A VIG S +VG+P ++ LL Sbjct: 119 NPTSLGRLALGLPAFAPATAAAVVEILRRGDVPMAGARACVIGRSPVVGKPAALLLLAED 178 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD 243 T TV H T++L AD+++ AVG+P + +++ GA VIDVG N + G +VGD Sbjct: 179 ATVTVCHSRTRDLATVAHEADIVVAAVGRPKLVGAGFVRPGATVIDVGTNVTDEG-LVGD 237 Query: 244 VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 V + A A +TPVPGGVGP+T L+ NT+QA Sbjct: 238 VDADAIAGVAGALTPVPGGVGPVTTMLLLRNTVQAAHRAR 277 >UniRef50_A6LP88 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Thermosipho melanesiensis BI429 RepID=FOLD_THEM4 Length = 271 Score = 261 bits (668), Expect = 2e-68, Method: Composition-based stats. Identities = 93/279 (33%), Positives = 158/279 (56%), Gaps = 14/279 (5%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 IID K + + ++ + ++++ R P L V +P++ Y+ S+ KA + G Sbjct: 2 IIDVKPLYEDIKVNLLKRIEKLK----RTPKLVAVTFKPDPSTVSYLKSQEKAAKRFGLD 57 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + E S +L+++ L+ DN ++GI V PL + ++ +++ E + P KD++G H Sbjct: 58 YEIF---EGNSPKGVLKILAELSRDNNVNGIFVTHPL-SQVNEMEIFENLVPSKDIEGRH 113 Query: 125 PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG- 183 PYN+G L PCT +V ++E I G N V++G SN VG+P+++ LL Sbjct: 114 PYNLGMLAYGEEFFAPCTAEAVVRIMEN-EIGIPGKNVVIVGRSNTVGKPLAIMLLRRDR 172 Query: 184 -CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVG 242 T TV H T+NL + AD+++ A G+PG I D +++ +I+IDVGIN + G ++G Sbjct: 173 SATVTVCHTKTRNLSSITKGADVVVAAAGRPGLITVDMVEKDSIIIDVGINVTDEG-IIG 231 Query: 243 DVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 DV +D A A +TPVPGGVG +T L+E+ +++ + Sbjct: 232 DVS-KDVANFAK-VTPVPGGVGKITTILLMEHLVKSAEK 268 >UniRef50_B9KZ23 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=FOLD_THERP Length = 288 Score = 261 bits (668), Expect = 2e-68, Method: Composition-based stats. Identities = 100/268 (37%), Positives = 152/268 (56%), Gaps = 4/268 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 MAA I+ G+ + + + + + Q+V AR A P L V+L ++P++Q Y + RK Sbjct: 1 MAAHILSGRPVVESLHARI-QQVLARRAPHQGPPTLTVLLP-NDPSAQAYARAIRKQFTT 58 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 + R+ ++ +T E+ L+ L D ++ GIL PLP G+ + + P KDV Sbjct: 59 LSLNYRTEEIDDTLDESRFAILLKRLAEDESVTGILALQPLPKGVSRRSLARLMPPTKDV 118 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG GRL +P + P TP G + LL+ Y I+ G +AVVIG S +VGRP+++ LL Sbjct: 119 DGVSFEQQGRLAIGSPWIAPSTPLGGLILLQHYGIEVAGRHAVVIGRSPVVGRPLALLLL 178 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T T+ HR T +L ADLL VA G+P + D + GA+VID G++ + +G++ Sbjct: 179 ARDATVTICHRRTPDLAKLTRQADLLFVAAGQPHLVKPDMVAPGAVVIDFGVS-VRDGRL 237 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTV 268 +GDV A+ AS +TPVPGG GP+T Sbjct: 238 IGDVD-PAVAEVASALTPVPGGTGPVTT 264 >UniRef50_UPI00006CB712 tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain n=1 Tax=Tetrahymena thermophila RepID=UPI00006CB712 Length = 377 Score = 261 bits (667), Expect = 2e-68, Method: Composition-based stats. Identities = 100/285 (35%), Positives = 162/285 (56%), Gaps = 15/285 (5%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +++G I++ V +V +++ +R P LA++LVG+ S YV+ K++AC+ VG Sbjct: 29 ILVNGNKISKDVLQKVKERILRV---NIREPKLAIILVGNAADSISYVSVKQRACKRVGV 85 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 S LPETT++ E++++++ LN +D IL QLP PA I V+ +I P KDVDG Sbjct: 86 QSELIHLPETTTQKEVIQIVEDLNKREDVDSILTQLPFPAQISKTIVINQIEPSKDVDGL 145 Query: 124 HPYNVGRLC---QRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 + + R PCTP+ + +L+ + ID G V++G +VG P+ LL Sbjct: 146 QRCFLTQQLIWDDHNNRALPCTPQSCLHILDTHKIDVKGKQVVMLGKGLLVGSPLGAILL 205 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL----E 236 G ++ + + +L +++AD+L+ A G + G+ +K+G IVIDVG +R + Sbjct: 206 GRGAIVSMCDKKS-DLSIALKDADILVSATGVRKLVKGEQLKKGVIVIDVGCSRPLPHED 264 Query: 237 NGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 +VGDV FE AS +TPVPGGVGP+TV+ LI+N ++ Sbjct: 265 QSSIVGDVEFES----ASLLTPVPGGVGPVTVSMLIQNVVKQWER 305 >UniRef50_Q1J118 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=Deinococcus RepID=FOLD1_DEIGD Length = 288 Score = 260 bits (665), Expect = 3e-68, Method: Composition-based stats. Identities = 96/292 (32%), Positives = 141/292 (48%), Gaps = 8/292 (2%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARI-AAGLRAPGLAVVLVGSNPASQIYVASKRKACE 59 M + GK +A V V ++ A P L VL + AS++YV SK + E Sbjct: 1 MTKAQLFGKPLADDVTRGVRAALKEWAGAEPGFQPHLVSVLASEDEASRVYVHSKARQAE 60 Query: 60 EVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKD 119 +G + DL + EL ++ L+AD + G++++LPL G+D L I P KD Sbjct: 61 RLGVRFTARDLGADAKQDELHAVLQALSADADVHGVVLELPLAPGLDADAALRHIAPCKD 120 Query: 120 VDGFHPYNVGRLCQRA--PRLRPCTPRGIVTLLER-YNIDTFGLNAVVIGASNIVGRPMS 176 V+G P N+ + L P TPR + LL D G VIG VGRP++ Sbjct: 121 VEGLTPANLALIAAGREAEALLPPTPRSVRFLLREVLGDDLRGRRVAVIGPGRTVGRPLT 180 Query: 177 MELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE 236 L G T T+ + T++LR + D ++VAVG G + + ++ +VID GIN Sbjct: 181 FMLNNRGVTVTLCNECTRDLRDVLAPQDAVVVAVGHAGLLRPEQVQPHHVVIDAGINVTP 240 Query: 237 NGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQDE 288 G VVGD V + TPVPGGVGP+T A + +N ++A + E Sbjct: 241 GG-VVGDAVPDLP---VRAQTPVPGGVGPLTSALMYQNLVRAVKLQRGERVE 288 >UniRef50_B7J0W5 Methenyltetrahydrofolate cyclohydrolase n=22 Tax=Borrelia RepID=FOLD_BORBZ Length = 308 Score = 259 bits (663), Expect = 6e-68, Method: Composition-based stats. Identities = 96/283 (33%), Positives = 147/283 (51%), Gaps = 10/283 (3%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLR-APGLAVVLVGSNPASQIYVASKRKACEEVG 62 + +GK A + + + LR L VVL PAS +YV+ K + +E+G Sbjct: 10 IVFNGKDFANKYYLMLK---EFLKQHNLRDKIALKVVLANDEPASNLYVSIKSRVAKEIG 66 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 + ++++LE+ID N + + DGI+VQLPL G+D +L I KDVDG Sbjct: 67 LNVEVIKFSANSVQSDILEVIDRENKNLSTDGIIVQLPLLKGMDLNSILNSIVYSKDVDG 126 Query: 123 FHPYNVGRLCQR-APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 N+G++ PCT ++ +L I T G VV+G S +VGRP+S+ L Sbjct: 127 LSFVNLGKMILGDKKGFIPCTALAVLKILRDEGIKTLGKTVVVVGRSPLVGRPISILLSS 186 Query: 182 A--GCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE--N 237 T H + L ++ AD++I AVGKP I + VID+GI+ +E N Sbjct: 187 KPYDATVIACHSKSIYLDVYLRQADIVISAVGKPRLIDKSMLCGKPYVIDIGISEIETDN 246 Query: 238 GKVV-GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 GK++ GD F++ + +ITPV GG+GP+TV L+ NT++A Sbjct: 247 GKILSGDTDFDNIKECVKFITPVKGGIGPVTVLMLMFNTIKAH 289 >UniRef50_C4XED5 Putative uncharacterized protein n=1 Tax=Mycoplasma fermentans PG18 RepID=C4XED5_MYCFE Length = 298 Score = 259 bits (663), Expect = 7e-68, Method: Composition-based stats. Identities = 106/287 (36%), Positives = 158/287 (55%), Gaps = 10/287 (3%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 KI+DGKT+AQ+ E+ + + R P L+++ VG NPAS Y+ +K K EE+G Sbjct: 15 KILDGKTLAQKRTKELIAQFKDIKEKLGRKPILSIIQVGDNPASTHYIKNKLKKAEELGV 74 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 + + P + +LL+ +D +N + DGI++QLPLP +L+ + +KD+DG Sbjct: 75 EAIHHHFPADIRQKDLLKKLDIINEKS--DGIVIQLPLPKEFATQVILDSVRIEKDIDGL 132 Query: 124 HPYNVGRLCQRAPRL--RPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 N +A P T GI+ LL YNI A VIG S++VG+P + L Sbjct: 133 CTRNAFNFYNQADDFTLVPATAIGILDLLNSYNIKMIDKKAAVIGRSSLVGKPTAFLLKQ 192 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE-NGK- 239 GC + +R T VENAD+++VA G+ + + IKEGA+V+DVG N +E +GK Sbjct: 193 EGCNVSTYNRNTG--IKGVENADIIVVAAGEAKLLKKENIKEGAVVVDVGSNWIEVDGKK 250 Query: 240 -VVGDVVFEDAAKRA-SYITPVPGGVGPMTVATLIENTLQACVEYHD 284 + GDV E + S + PVPGGVGPMTV +L N ++ + H Sbjct: 251 ILHGDVDIETIPENYLSALAPVPGGVGPMTVISLFTNLAKSIIHIHR 297 >UniRef50_D1B5M7 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B5M7_THEAS Length = 292 Score = 255 bits (653), Expect = 9e-67, Method: Composition-based stats. Identities = 103/286 (36%), Positives = 147/286 (51%), Gaps = 11/286 (3%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 ++ G A V+ V ++V A LA V V S+ AS+ Y ++ +AC+E G + Sbjct: 3 LMRGSEPASWVKGWVRRQVSAL-----GGCCLASVSVSSHGASEAYRRNQIRACQEAGIL 57 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 R D+ + L+E I LN D +DGI+VQ PLP G D +VL+ + P KD +G H Sbjct: 58 VRPVDVAPSLGILGLIETIRELNGDREVDGIIVQTPLPEGWDLSEVLQAMDPAKDAEGVH 117 Query: 125 PYNVGRLCQRAPRL-RPCTPRGIVTLLERYNI-DTFGLNAVVIGASNIVGRPMSMELLLA 182 P N+G+L PC V LLE Y + D G+ V+G S VGRP+ LL Sbjct: 118 PENLGKLFLGVKGHPLPCAAWAAVGLLEWYGLWDLSGMVCAVVGHSVNVGRPIGALLLQR 177 Query: 183 GCTTTVTHRFTKN--LRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T H+ T L V ++ ++I A G PG I ++ GA V+DVG E G + Sbjct: 178 NGTVLQMHKHTPRDVLEELVSSSQVVISATGVPGLIGPGMVRPGAWVVDVGTTPTERG-L 236 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQ 286 VGDV A A ++PVPGGVGP+TVA L+ N + + + + Sbjct: 237 VGDVD-PQCASVAHGLSPVPGGVGPLTVALLMANLVLLASKRRNGR 281 >UniRef50_Q4DH06 Methylenetetrahydrofolate dehydrogenase-like protein, putative n=1 Tax=Trypanosoma cruzi RepID=Q4DH06_TRYCR Length = 375 Score = 254 bits (649), Expect = 3e-66, Method: Composition-based stats. Identities = 102/331 (30%), Positives = 154/331 (46%), Gaps = 57/331 (17%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A+I+ G+ ++ + + +V + P LAVV+VG+ S+ YV+ K++ E Sbjct: 1 MKAEILLGRPLSGTLIERIQHEVARLSCS----PSLAVVMVGNRQDSRRYVSVKQRTAEA 56 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 G LPET SE L + + ++ DN DG+L+QLP+P+ + L IHP KDV Sbjct: 57 CGIRFHLLSLPETVSEERLHQELRRISDDNAFDGVLLQLPIPSHLRVRPALLCIHPGKDV 116 Query: 121 DGFHPYNVGRLCQRAP----------------------------RLRPCTPRGIVTLLER 152 DG HP N G L PCT + LL Sbjct: 117 DGLHPINAGSLFLDGNPIYEEAVHRGSSAEKEEALASRLLNEGRYFVPCTALAVHALLFS 176 Query: 153 YNID-----------TFGLNAVVIGASNIVGRPMSMELL-LAGCTTTVTHRFTKNL---R 197 Y + L+AV+I S +VG P + L T+ + +L + Sbjct: 177 YLANRTAVVPTPSKKPKNLHAVIINKSMVVGVPTAALLQKEDNFLVTLC-SRSNDLEAVK 235 Query: 198 HHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL---------ENGKVVGDVVFED 248 AD+L+ A+G P + D++K GAIV+DV IN + +V GDV Sbjct: 236 EVSRQADVLVTALGIPRVVTADFVKPGAIVLDVAINEDCASGGEMTSGSRRVCGDVDLAS 295 Query: 249 AAKRASYITPVPGGVGPMTVATLIENTLQAC 279 ++A+ +TPVPGG+GP+TVA L++NTL+A Sbjct: 296 VREKAAAVTPVPGGIGPLTVAYLMQNTLKAH 326 >UniRef50_A5IXS7 FolD bifunctional protein(Methylenetetrahydrofolate Dehydrogenase; Methenyltetrahydrofolate cyclohydrolase) n=1 Tax=Mycoplasma agalactiae PG2 RepID=A5IXS7_MYCAP Length = 286 Score = 253 bits (647), Expect = 4e-66, Method: Composition-based stats. Identities = 98/283 (34%), Positives = 147/283 (51%), Gaps = 11/283 (3%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 I++GK IA++ E+ ++ + R P L+++ VG NPAS +Y+ +K K EE+G Sbjct: 3 ILNGKIIAEERTVELKKEFEEITKLIGRQPVLSIIQVGDNPASSLYIKNKIKKAEELGVK 62 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFH 124 + Y E S+ LL+ +D LN ++ DGI+VQLPLP I ++ I +KDVDG Sbjct: 63 ATLYKFDEDISQNSLLKKLDVLNEES--DGIIVQLPLPEHISPKVIMNGIRLEKDVDGLC 120 Query: 125 ---PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 +N P T I+ L+ Y ID G A VIG S +VG+P + L Sbjct: 121 EKSTFNFYNDKYDELSFTPATAAAIIDLINYYKIDLNGKKAAVIGRSYLVGKPTAFLLKK 180 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE-NGKV 240 G + ++ T + VE+ADLL+ A G+P + + IK+GA +ID G +E GK Sbjct: 181 LGAMVSTYNKNTG--INGVESADLLVSAAGQPDLVKKENIKDGAWLIDAGTTMIEREGKK 238 Query: 241 V--GDVVF-EDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 GD + + TP PGG+GP+TV L +N +A Sbjct: 239 CFVGDASLTPEEYQLLEGYTPTPGGIGPLTVIWLFKNLAKAIK 281 >UniRef50_Q4RT28 Chromosome 12 SCAF14999, whole genome shotgun sequence n=1 Tax=Tetraodon nigroviridis RepID=Q4RT28_TETNG Length = 342 Score = 252 bits (644), Expect = 1e-65, Method: Composition-based stats. Identities = 92/220 (41%), Positives = 126/220 (57%), Gaps = 10/220 (4%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A +I G+ +A+Q+R E V+ + G R P L+VVLVG +PAS YV +K +A ++ Sbjct: 29 EAVVISGRKLARQIREEARADVEKWVLTGHRRPHLSVVLVGDDPASHSYVLNKTRAAADI 88 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G S + SE ELL+LID LN D+ +DG+LVQLPLP ID + + P KDVD Sbjct: 89 GISSETILKHSDISEEELLDLIDKLNTDHRVDGLLVQLPLPEHIDERTICNAVAPTKDVD 148 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GFH NVGR+C + P TP G+ +++R I T G N VV G S VG P++M L Sbjct: 149 GFHVVNVGRMCLDQSSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHT 208 Query: 182 AG--------CTTTVTHRFTK--NLRHHVENADLLIVAVG 211 G T T++HR+T L H + AD++I A G Sbjct: 209 DGRHERPGGDATVTISHRYTPKEQLCQHTKIADIVIAAAG 248 >UniRef50_D1VRZ1 Bifunctional protein FolD n=1 Tax=Peptoniphilus lacrimalis 315-B RepID=D1VRZ1_9FIRM Length = 284 Score = 246 bits (628), Expect = 8e-64, Method: Composition-based stats. Identities = 82/265 (30%), Positives = 134/265 (50%), Gaps = 6/265 (2%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 KI+ K + ++++ ++ +K++ P LA++ +G P Y K +E+ Sbjct: 12 MTKILTSKDLRKRLKEKLLEKIENLNEK----PVLAIIRLGQRPEDLSYEKGLTKTAKEL 67 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 Y L T +L+ LI+ LN D + GIL+ PLP ID +V I P KD+D Sbjct: 68 SIPVDIYKLEVQTKTIQLISLIEKLNEDKKVKGILIFRPLPKHIDEKEVALAISPQKDLD 127 Query: 122 GFHPYNVGRLCQRA-PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 +P N ++ P +P+ V L+E Y + A++I S +VG+P++M LL Sbjct: 128 CINPINKAKIYDGDVNGFIPLSPKAAVMLMEDYGYNLA-KRALIINRSQVVGKPLAMLLL 186 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 T T+ H T+N++ ++ +D + A+GK + + E +I+ID+ I ENGK+ Sbjct: 187 NRNATVTIAHSKTENIKELIKKSDYVFTAMGKMKSLDRSFFTEKSIIIDLSIGIDENGKL 246 Query: 241 VGDVVFEDAAKRASYITPVPGGVGP 265 GD+ ED TPVPGGVG Sbjct: 247 CGDIDQEDVNDFVQAYTPVPGGVGS 271 >UniRef50_UPI00003BDED9 hypothetical protein DEHA0E19294g n=2 Tax=Debaryomyces hansenii CBS767 RepID=UPI00003BDED9 Length = 276 Score = 245 bits (626), Expect = 1e-63, Method: Composition-based stats. Identities = 89/239 (37%), Positives = 129/239 (53%), Gaps = 16/239 (6%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIA--------------AGLRAPGLAVVLVGSNPASQ 48 A ++ G +A+ +RS++A+K+ P L ++ VG P S Sbjct: 31 AAVVSGTLLAKSIRSKIAEKIVDYNTTNFSNLNASNINFDNLQFRPNLTIIQVGGRPDSS 90 Query: 49 IYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNV 108 YV +K KA + +S E SE +LLE ID LN D ++G+L+QLPLP + Sbjct: 91 AYVKAKLKAAKSSNILSSLLKFDEDMSEEDLLEEIDRLNKDPKVNGLLIQLPLPKHFNET 150 Query: 109 KVLERIHPDKDVDGFHPYNVGRLCQ--RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIG 166 + + +KDVDGF YNVG L + AP +PCTP GI+ L++ I G NAVV+G Sbjct: 151 LITNAVATEKDVDGFARYNVGELTKKGGAPMFKPCTPNGIMELIKTTGISLRGKNAVVLG 210 Query: 167 ASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGA 225 S+IVG P++ L CT T+ HR T +L V NAD+++ AVG P ++ DW+KE Sbjct: 211 RSDIVGTPVAAMLRNEDCTVTICHRHTYDLPSVVRNADIIVAAVGIPEYVKADWVKENV 269 >UniRef50_A7AXK7 Putative uncharacterized protein n=1 Tax=Ruminococcus gnavus ATCC 29149 RepID=A7AXK7_RUMGN Length = 276 Score = 244 bits (624), Expect = 2e-63, Method: Composition-based stats. Identities = 91/258 (35%), Positives = 142/258 (55%), Gaps = 14/258 (5%) Query: 29 AGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNA 88 + P LAV+ + + AS Y+ K+K C+E+G R ++ T+E + +E + T A Sbjct: 25 HLDKKPVLAVIQIDDDQASNSYIKGKQKDCDEIGIEMRHVNIYSNTTEQKEVECVITDIA 84 Query: 89 DNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVT 148 + DGI++QLP+P + ++ I P+KDVDGF ++ +PCTP+GI+ Sbjct: 85 KSDADGIIIQLPIPDKYNLERLQHLIPPEKDVDGF---------RKDSCFKPCTPKGIID 135 Query: 149 LLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIV 208 +E N + G + V+G S IVG P++ L+ G T T + T + ++ NAD Sbjct: 136 WMEYNNFEFEGKDCCVLGRSKIVGLPLTNMLIEKGATVTCCNSTTPSTWYYTRNADYAFS 195 Query: 209 AVGKPGFIP-GDWIKEGAIVIDVGINRLENGKVVGDVV---FEDAAKRASYITPVPGGVG 264 AVG P + D+ +V+D+GINR ENGK+ GDV FE + +Y+TPVPGGVG Sbjct: 196 AVGVPNYFDFSDFQDFCELVVDIGINRDENGKLCGDVNNAGFESSLN-DTYVTPVPGGVG 254 Query: 265 PMTVATLIENTLQACVEY 282 +T TL++N + A Sbjct: 255 LLTRLTLMQNVVDAYKVQ 272 >UniRef50_Q6KID0 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Mycoplasma mobile RepID=FOLD_MYCMO Length = 280 Score = 242 bits (619), Expect = 9e-63, Method: Composition-based stats. Identities = 98/283 (34%), Positives = 144/283 (50%), Gaps = 11/283 (3%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 I+DGK ++Q+ + +KV P +V VG+ +S Y+ +K E+G Sbjct: 2 IILDGKKLSQKDTIFLKEKVNQFK----IKPVFTIVQVGNLFSSNKYIKTKMDKALEIGV 57 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGF 123 VSR +PE+ SE +L+ +I+ G++VQLPLP D K+L + KD+DG Sbjct: 58 VSRLIKIPESISEKDLISIIEE--ESKISHGLIVQLPLPLQFDQSKILNSVPITKDIDGL 115 Query: 124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 N L ++P T RGI+ L++ YN VIG SN+VG+P+ AG Sbjct: 116 SEKNSKNLYSGKSCIQPATARGIIDLIKEYNFTIKDKKVYVIGESNLVGKPIKELFKQAG 175 Query: 184 CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGK---V 240 + T E AD+LIVA G P + + +K +IVIDVGIN + V Sbjct: 176 AIVKSFNINTG--IKGSEEADILIVAAGHPNLVKPENVKNNSIVIDVGINSIGENDKMIV 233 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 GDV F + + I+PVPGGVGPMTV +L +N ++ +Y Sbjct: 234 TGDVDFSNVKTKVKAISPVPGGVGPMTVISLFKNLIEIFEKYL 276 >UniRef50_D1J7X9 Methylenetetrahydrofolate dehydrogenase n=1 Tax=Mycoplasma hominis ATCC 23114 RepID=D1J7X9_MYCHP Length = 292 Score = 242 bits (618), Expect = 1e-62, Method: Composition-based stats. Identities = 95/284 (33%), Positives = 157/284 (55%), Gaps = 9/284 (3%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A +++GK I+ +V+ ++ + ++ P L ++ VG S IYV +K K ++ Sbjct: 1 MAILLNGKAISLKVKEDLKKAIEKMPQE--IRPTLGILQVGDLSESNIYVKNKLKYASDI 58 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAG--IDNVKVLERIHPDKD 119 G ++ L + S+ ++ E I+ LN + G +VQ+P+ ID+ ++L+ I D D Sbjct: 59 GLNTKLIKLQQNASKLQIAEAIELLNKQS--TGFIVQIPMQTNQIIDSQEILDLISIDHD 116 Query: 120 VDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 +DG +N+ L T GI LL +YNI VIG S IVG P++ L Sbjct: 117 IDGLTSFNLD-LKNPNNYFLSATASGIFLLLNKYNILYKNAKIGVIGQSKIVGYPLANFL 175 Query: 180 LLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGK 239 +L G ++ T ++++++ D++IVA G I D +K GA++IDVGI+R N K Sbjct: 176 VLKGYNVFRYNKDTP--KNNIKDLDIIIVATGTKDPITYDQVKPGAVIIDVGIHRDSNNK 233 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 + GD+ F + + AS+ITPVPGGVGPMT++ L+ N L+A + Sbjct: 234 ISGDLNFNEFSNVASFITPVPGGVGPMTISALLINLLKASSLQN 277 >UniRef50_B3PMJ8 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Mycoplasma arthritidis 158L3-1 RepID=FOLD_MYCA5 Length = 293 Score = 239 bits (611), Expect = 7e-62, Method: Composition-based stats. Identities = 94/285 (32%), Positives = 156/285 (54%), Gaps = 11/285 (3%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 I+DGK +++ +++++A A P L ++ VG+ S IYVA K K E + Sbjct: 1 MPVILDGKRLSEALQAKIAMAFSAYR---GPKPILGILQVGNKEDSNIYVAHKLKVAESL 57 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGI--DNVKVLERIHPDKD 119 GF+++ +PE +++ E++ + NA + GI+VQLPL + + ++L+ I +KD Sbjct: 58 GFLTKLVKMPENSTQDEIIGTLR--NAAAEVTGIIVQLPLVSNRIENLQEILDNIPIEKD 115 Query: 120 VDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMEL 179 +DG YN+ TP+GI+ LL+ YNI+ ++G SNIVG+P++ L Sbjct: 116 IDGLSSYNLASNYNCKDNFLSATPKGIILLLKHYNINFRSTVIALVGQSNIVGKPLAKYL 175 Query: 180 LL-AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 T + T + + A ++IVA G + D + G ++IDVGI+R + Sbjct: 176 SNFKNNTIKTYVKDTP--KDDLHEAKIVIVATGVYQSVTADQLANGTVLIDVGIHR-QGK 232 Query: 239 KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 + GD+ F K+ASYITPVPGGVGP+TV L+ N ++A + + Sbjct: 233 TIHGDLDFASCFKKASYITPVPGGVGPLTVVALMFNLIKALILQN 277 >UniRef50_A9BIV9 Methenyltetrahydrofolate cyclohydrolase n=3 Tax=Thermotogaceae RepID=FOLD_PETMO Length = 273 Score = 237 bits (606), Expect = 2e-61, Method: Composition-based stats. Identities = 86/272 (31%), Positives = 143/272 (52%), Gaps = 12/272 (4%) Query: 13 QQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPE 72 + E+ ++ + P L ++V + +++ Y+ S+++ ++ G + Sbjct: 6 DNIIDEIKAEISSLKEKVPYEPKLVSLVVEPDESTKSYLNSQKRNAKKFGINLEIVE--- 62 Query: 73 TTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLC 132 +L + N D+ D I + PL G + + + I+P+KDV+G +N+G + Sbjct: 63 ---SNDLTNDLRKYNEDDDTDAIFIARPLKKGYTELDIAKYINPEKDVEGVSLHNIGSMF 119 Query: 133 QRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAG--CTTTVTH 190 PCT +V ++E D G N V++G S VG+P ++ L G T TVTH Sbjct: 120 YEKELFVPCTAEAVVKIIEDT-TDVRGKNIVILGRSTTVGKPAAIMLQRHGRDATVTVTH 178 Query: 191 RFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAA 250 TKNL+ + AD+L+ A+GK F+ ++KEG IVIDVGIN + +GK+VGDV +D + Sbjct: 179 TKTKNLKEITKEADILVAAIGKANFVDSTFVKEGMIVIDVGINVV-DGKIVGDVN-KDVS 236 Query: 251 KRASYITPVPGGVGPMTVATLIENTLQACVEY 282 + +TPVPGGVG +T A L+ N +A Sbjct: 237 EIC-QLTPVPGGVGSVTTAILMRNVFRAANNK 267 >UniRef50_P47259 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Mycoplasma RepID=FOLD_MYCGE Length = 273 Score = 237 bits (604), Expect = 5e-61, Method: Composition-based stats. Identities = 82/276 (29%), Positives = 132/276 (47%), Gaps = 14/276 (5%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 DGK AQ + L ++ + +S ++ K AC VG S Sbjct: 3 FDGKLKAQSILE-------TYKNFDWSKCKLVIIQANDDDSSDSFIKQKLIACNTVGAKS 55 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 L ++AEL+E I +LN D + GI++QLP+ +D +LE I+P KDVDG Sbjct: 56 ELIKLSNQITQAELIEKIISLNHDVNVTGIILQLPVYPHLDKNSLLEAINPLKDVDGLTT 115 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCT 185 ++ ++PC I+TL E +N++ VV+G G+P+ L +G Sbjct: 116 NHLA-------EIKPCIVEAIITLKELFNLEFNNQKIVVVGLGITGGKPIYEFLKTSGYK 168 Query: 186 TTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVV 245 + T N +++AD++ A+GK F K+G I+ D+G++R + K+ GD+ Sbjct: 169 VQACDKDTPNTFELIKSADIVFTAIGKSHFFQAKNFKKGVILFDIGVSRNKQNKLCGDIN 228 Query: 246 FEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 E K+A + T PGGVGP TV +I+N + Sbjct: 229 PEGIEKKARWWTKTPGGVGPFTVLAIIKNLWILHEK 264 >UniRef50_Q5IWX9 Plastid 5,10-methylene-tetrahydrofolate dehydrogenase (Fragment) n=1 Tax=Prototheca wickerhamii RepID=Q5IWX9_PROWI Length = 248 Score = 233 bits (594), Expect = 7e-60, Method: Composition-based stats. Identities = 90/189 (47%), Positives = 115/189 (60%), Gaps = 2/189 (1%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A +IDGK IA+ +R E+ +V A PGLAVVLVG SQ YV SK+KAC+E Sbjct: 60 MPAALIDGKKIAETIRGELKVEVDELRAQYNTVPGLAVVLVGERKDSQTYVRSKKKACDE 119 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG S DLPET +E E+L ++ N D + GILVQLPLP I+ +VL+ I +KDV Sbjct: 120 VGINSFGADLPETATEEEVLAVVAKFNDDPNVHGILVQLPLPEHINEKRVLDAISLEKDV 179 Query: 121 DGFHPYNVGRLCQ--RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSME 178 DGFHP N+G L R+P CTP+G + LL+R + G A V+G SNIVG P ++ Sbjct: 180 DGFHPNNIGELAMRGRSPTYVSCTPKGCLELLKRAGVTLAGKRAAVVGRSNIVGLPAALL 239 Query: 179 LLLAGCTTT 187 L T T Sbjct: 240 LQQEDATVT 248 >UniRef50_Q98QV3 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Mycoplasma pulmonis RepID=FOLD_MYCPU Length = 272 Score = 230 bits (586), Expect = 6e-59, Method: Composition-based stats. Identities = 85/282 (30%), Positives = 138/282 (48%), Gaps = 11/282 (3%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M K++ + Q R+E+ +K A+VL+G N +S+IYV K + ++ Sbjct: 1 MMKKLLS-NELVQIKRAELKEKFSKLDQKV----KFAIVLIGDNASSKIYVKKKIEFAQD 55 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 +G ++ + E L + + D DGI++QLP+ D ++L I +KD+ Sbjct: 56 IGVEAKLFHFEENVDFNLLKDAFKKI--DKEYDGIILQLPVL-HFDVNELLLMIDKNKDL 112 Query: 121 DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL 180 DG +P N + + P T R I T L+ + I V+G S +VG+P+S L Sbjct: 113 DGLNPENEKAFYENRECIIPATARAIWTFLKFHKISVENKKVFVVGQSRLVGKPISQFLK 172 Query: 181 LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV 240 V + T E AD+LIVA G I + IKE +I+IDVG +++ N K+ Sbjct: 173 NNNAIVRVFDKSTG--LKGTEEADILIVATGVAQLIKAENIKENSILIDVGFSKI-NNKI 229 Query: 241 VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 GD+ E ++A TP G +GP+TV +L EN + ++ Sbjct: 230 YGDLDIESIKEKALKYTPPIGAIGPVTVLSLFENLYEIILKK 271 >UniRef50_A1RQQ5 Methenyltetrahydrofolate cyclohydrolase n=5 Tax=Thermoproteaceae RepID=FOLD_PYRIL Length = 311 Score = 229 bits (585), Expect = 6e-59, Method: Composition-based stats. Identities = 100/290 (34%), Positives = 147/290 (50%), Gaps = 20/290 (6%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNP----ASQIYVASKRKACEEV 61 I G + + + V+ P LAV+L+ +P YV+ K + + + Sbjct: 5 IKGDRLHTETLEWARRHVKEL-ERYGVTPKLAVLLLNDDPIELETQHKYVSLKARDIKSI 63 Query: 62 GFVSRSYDL---PETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDK 118 G ++L P E L+LI+ LN + + GILVQ PLP +D K+ ER+ P K Sbjct: 64 GGEVELFELYKEPPEKREVAALKLIERLNNADDVTGILVQKPLPPYVDETKIFERLSPLK 123 Query: 119 DVDGFHPYNVGRLCQR---APRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPM 175 DVDG P N RL + PCTP GI+ L +Y ID G + VV+G +VG P+ Sbjct: 124 DVDGLTPENKKRLVTGFDLDRDILPCTPAGILELFRQYKIDVRGKDVVVVGKGTLVGFPL 183 Query: 176 SMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGK--------PGFIPGDWIKE-GAI 226 S+ L+ T TV H +K+ +++V NAD++I AVG+ P + GD+IKE + Sbjct: 184 SIMLMQLDATVTVLHALSKDRKYYVRNADIIISAVGRPPELYSDNPWKLTGDFIKEGAVV 243 Query: 227 VIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 V G K DV + A++ASY+TP GGVG T A L++N + Sbjct: 244 VGVGGKVDPVTKKWYFDVDEKSVAEKASYLTPNIGGVGLATRARLVKNLI 293 >UniRef50_Q0AZF5 Methenyltetrahydrofolate cyclohydrolase n=1 Tax=Syntrophomonas wolfei subsp. wolfei str. Goettingen RepID=FOLD1_SYNWW Length = 277 Score = 228 bits (582), Expect = 2e-58, Method: Composition-based stats. Identities = 96/284 (33%), Positives = 145/284 (51%), Gaps = 12/284 (4%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGF 63 +II G IAQ++R ++ +K +P LA++LVG YV K KA G Sbjct: 2 EIISGSQIAQEIRQKLKEK----NEREGISPCLAMILVGGQKEDLHYVGLKEKAATATGG 57 Query: 64 VSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNV--KVLERIHPDKDVD 121 SR LPE TS+ EL+ I LN D +DGIL+QLPLPA ++ ++L I PDKDVD Sbjct: 58 KSRLLHLPEDTSQQELMAKIAELNQDEQVDGILLQLPLPAALEEQTDEILAAIRPDKDVD 117 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GF N GR+ P C + ++ER+ G AV++G S + P++ ++ Sbjct: 118 GFSLVNRGRMSGDRPGFISCAALACLEVIERFFPSLAGKKAVLVGDSFDLIIPLATIMIK 177 Query: 182 AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 C +V + L AD+L+V G+ G + + + G ++ID G G V Sbjct: 178 RACQLSVLPSYEPGLASG---ADILVVEKGRAGIVQAEGLAPGVLIIDAGF-YWGAGGVC 233 Query: 242 GDVVFEDAAKRA--SYITPVPGGVGPMTVATLIENTLQACVEYH 283 G+V ++ + + PVPGG+GP+ +A L+EN QA + Sbjct: 234 GNVDRAALERQGFEARLLPVPGGMGPILIAKLMENLAQAARQKR 277 >UniRef50_C7GZF5 FolD protein n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7GZF5_9FIRM Length = 293 Score = 223 bits (569), Expect = 5e-57, Method: Composition-based stats. Identities = 82/294 (27%), Positives = 136/294 (46%), Gaps = 24/294 (8%) Query: 7 DGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSR 66 D K I++++ E+ V +A+V N A +Y + K E++ R Sbjct: 4 DCKQISEELLGEIKNDVAHL----GFNKEIAIVKSAKNSAGTVYENAIIKKAEKLNIPVR 59 Query: 67 SYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPY 126 S L E + + + L+ D I GI+ PL ID +V E I +KD+DG Sbjct: 60 SAVLEEGVDTEKAFKTVAKLSEDKDIAGIIPMQPLDESIDISRVKEAIACNKDIDGQTEK 119 Query: 127 NV-GRLCQRAPRLRPCTPRGIVTLLERY--NIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 ++ G R L P T + + ++ + L ++G S +VGRP+SM + Sbjct: 120 SMSGVFSFRKDALAPATALACIEIAKKVLGRENFKTLKVCILGRSLVVGRPLSMLFMKDD 179 Query: 184 CTTTVTHRFTK--NLRHHVENADLLIVAVGKPGFIPGDWI--------------KEGAIV 227 T TV H T N+ + +AD+++ AVG P F+ + + ++ + Sbjct: 180 ATVTVCHSKTGYDNIISSMADADIIVSAVGIPYFVTKEMVEGSFERRKELKSIDEDDRLF 239 Query: 228 IDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 IDVGIN ++GK+ GD+ E +Y+TPVP GVG +T + L +N L+ + Sbjct: 240 IDVGINF-KDGKITGDMESEAFKDEVAYVTPVPSGVGLVTTSVLFKNLLKGYRQ 292 >UniRef50_UPI00016B2244 FolD bifunctional protein n=2 Tax=candidate division TM7 RepID=UPI00016B2244 Length = 338 Score = 220 bits (562), Expect = 4e-56, Method: Composition-based stats. Identities = 88/281 (31%), Positives = 136/281 (48%), Gaps = 17/281 (6%) Query: 4 KIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGS-NPASQIYVASKRKACEEVG 62 KI++G +A V+ ++V+ + P L+VV V S N Y+ K+ ++ Sbjct: 67 KILNGAELASFVKVRQLKQVRNLRQSKKIIPKLSVVYVDSGNKVIDTYINLKKAYANDIL 126 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 Y T ++E ++ L+ D++I GI+VQLPLP +D ++L I+P+KDVDG Sbjct: 127 VEFSVYKENADT----IIERLNILSRDDSIHGIIVQLPLPGDLDTDQILSHINPNKDVDG 182 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 N P TP I LL Y ID G N ++G +VG P++ + Sbjct: 183 LSGGN----------FTPATPMAINWLLSGYGIDLSGKNVAIVGRGKLVGAPLTRLWKES 232 Query: 183 GCTTTVTHRFTK-NLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVV 241 G V + +L + D+++ A G G I +K GA+VID G E G + Sbjct: 233 GYNVDVFEKGDGYDLHIEIPKYDVIVTATGATGLIKSSMLKSGAVVIDAG-TASEKGIIK 291 Query: 242 GDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEY 282 GD+ + ++ ITP GGVGP+TVA L +NT+ A Sbjct: 292 GDLSDDVRERKDLIITPDKGGVGPLTVAALFDNTILAAYRQ 332 >UniRef50_B8ZZU9 Putative uncharacterized protein MTHFD2 n=2 Tax=Homininae RepID=B8ZZU9_HUMAN Length = 267 Score = 218 bits (556), Expect = 2e-55, Method: Composition-based stats. Identities = 94/298 (31%), Positives = 134/298 (44%), Gaps = 90/298 (30%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A +I G+ +AQQ++ EV Q+V+ +A+G + P L+V+LVG NPAS YV +K +A V Sbjct: 36 EAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVV 95 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 ID ++ + PDKDVD Sbjct: 96 -----------------------------------------EHIDERRICNAVSPDKDVD 114 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 GFH NVGR+C + P TP G+ +++R I T G N VV G S VG P++M L Sbjct: 115 GFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHT 174 Query: 182 AGC--------TTTVTHRFTK--NLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVG 231 G T T++HR+T L+ H AD++I A G Sbjct: 175 DGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAG-------------------- 214 Query: 232 INRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE--YHDPQD 287 ++A YITPVPGGVGPMTVA L++NT+ A + + ++ Sbjct: 215 -----------------VRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEERE 255 >UniRef50_A8IQS8 Methylenetetrahydrofolate dehydrogenase/ methylenetetrahydrofolate cyclohydrolase n=1 Tax=Chlamydomonas reinhardtii RepID=A8IQS8_CHLRE Length = 351 Score = 215 bits (549), Expect = 1e-54, Method: Composition-based stats. Identities = 94/284 (33%), Positives = 122/284 (42%), Gaps = 71/284 (25%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M +IDGK +A ++R E A K ++ + R PGLAVV+VG SQ YV K+K CE Sbjct: 25 MNGNVIDGKAVAAKIREETAAKSRSLKPSMARVPGLAVVIVGERKDSQTYVRMKKKVCE- 83 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VL I +KDV Sbjct: 84 ------------------------------------------------AVLGAISVEKDV 95 Query: 121 DGFHPYNVGRLCQ--RAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSME 178 DGFHP N+GRL R P PCTP G + LLER I G AVV+G SNIVG P ++ Sbjct: 96 DGFHPLNIGRLAMKGREPLFTPCTPLGCMVLLERCGIPIKGKRAVVVGRSNIVGMPAALL 155 Query: 179 LLLAGCTTTVTHRFTK--NLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLE 236 L TV H T + AD++I A G+ + G W+K GA VIDVG N ++ Sbjct: 156 LNKRDAAVTVVHSATPKADAEAMCRQADIIIAAAGQAQLVRGSWVKPGAAVIDVGTNPID 215 Query: 237 NGKVVGDVVFEDAAKRASYITP---VPGG-VGPMT--VATLIEN 274 + +A + P V G VG + A L+ Sbjct: 216 D------------KTKAGAVIPGEHVAGRWVGSVQARAAVLLRR 247 >UniRef50_UPI0001B58450 methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase n=1 Tax=Streptomyces sp. SPB78 RepID=UPI0001B58450 Length = 357 Score = 213 bits (543), Expect = 6e-54, Method: Composition-based stats. Identities = 70/212 (33%), Positives = 105/212 (49%), Gaps = 1/212 (0%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 A+ + GK +A +R V+A P LAVV + +S YV S A E+ G Sbjct: 12 ARPLRGKALAASLREGTRAAVEA-TRKAGSTPKLAVVTATDDESSAWYVRSLVSAAEKSG 70 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDG 122 + L S E+ + + L D ++ G+++Q PLP G+D + E + KDVDG Sbjct: 71 LLHEVVHLGPKASTEEVRDALRGLGEDGSVHGVILQTPLPPGVDARALAEAVPAAKDVDG 130 Query: 123 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 182 +P ++GRL P T ++ LL+ Y + G AVV+G S +VG+P++ LL Sbjct: 131 ANPLSLGRLAAGLAAFAPATAEAVIALLDHYEVPLRGARAVVVGRSTVVGKPLAHLLLAR 190 Query: 183 GCTTTVTHRFTKNLRHHVENADLLIVAVGKPG 214 T TV H T++L AD+LI A G G Sbjct: 191 DATVTVCHSRTRDLAEVTREADILIAARGAAG 222 >UniRef50_B0RZW6 Methylenetetrahydrofolate dehydrogenase n=2 Tax=Finegoldia magna RepID=B0RZW6_FINM2 Length = 267 Score = 213 bits (543), Expect = 6e-54, Method: Composition-based stats. Identities = 74/273 (27%), Positives = 129/273 (47%), Gaps = 14/273 (5%) Query: 13 QQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPE 72 +++R ++ +++ + R +A V VG N Y + + C ++ L E Sbjct: 7 KELREDLGKRIIDGVEKLGREVKVATVRVGENAGDISYEKAVKNNCAKLNITCDQIVLEE 66 Query: 73 TTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGR-L 131 +E L++ I LN T DGIL+ PL ++ I P+KD+D N+G+ L Sbjct: 67 GENEK-LIQTIKELNE--THDGILMFRPLKDKNLEKEIQYIIAPEKDIDAMGMVNLGKVL 123 Query: 132 CQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHR 191 P T R +V +++ YN D N V++ S ++G+P+ L+ T T+ H Sbjct: 124 AAEEDAYYPATARAVVEIVKYYNFDV--KNVVIVNRSLVLGKPLFNMLIKENKTVTMCHS 181 Query: 192 FTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFE-DAA 250 T++++ +NADL++ AVGK + + + V+DVG++ ENGK+ GDV E D Sbjct: 182 RTEDIKSFTKNADLVVTAVGKAKMFDDSYFTKDSYVVDVGVSLDENGKLSGDVNPEVDVK 241 Query: 251 KRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 A VG +T L+ ++ + Sbjct: 242 VLA-------NSVGKITTRVLLLQMVEGALNRQ 267 >UniRef50_B3QMF3 Tetrahydrofolate dehydrogenase/cyclohydrolase n=2 Tax=Chlorobaculum RepID=B3QMF3_CHLP8 Length = 296 Score = 213 bits (542), Expect = 6e-54, Method: Composition-based stats. Identities = 77/317 (24%), Positives = 120/317 (37%), Gaps = 54/317 (17%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A +D IA R V +++ + + +L +PAS Y R CE+ Sbjct: 1 MKA--LDPSPIAAAFRDAVRREISDEKLSIN----IVGILASDDPASATYADYTRAGCED 54 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV 120 VG TS + ++++ NAD+ + GI V P+ + ++ + I P KDV Sbjct: 55 VGISFDLRK----TSPESVRNMLESANADSDVHGIFVYYPIWGDSRDAELRDLISPHKDV 110 Query: 121 DGFHPYNVGRLCQRA---------PRLRPCTPRGIVTLLER------YNIDTFGLNAVVI 165 +G P+ + +L + PCTP I+ LLE Y + G + Sbjct: 111 EGLCPHWISKLYANERFDDEARKFKAILPCTPLAILKLLEETEAYIPYGLPFGGQQITIF 170 Query: 166 GASNIVGRPMSMELLLAGCTTTVT--------------HRFTK-NLRHHVENADLLIVAV 210 S +VGRP++ L G H + +D++I V Sbjct: 171 NRSEVVGRPLAYMLSNDGARVYSFDIDGGFVVDVNDPGHERVPVTREEALRQSDIVITGV 230 Query: 211 GKPGF--IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTV 268 F I D +K GA+ ++ + DA + A P VGPMTV Sbjct: 231 PSKVFDKIKADELKSGAVCLNFSSIQNFE---------PDAKESAGLYIP---RVGPMTV 278 Query: 269 ATLIENTLQACVEYHDP 285 A + N LQ YH Sbjct: 279 AMCMRNALQLYRNYHHE 295 >UniRef50_B8BYF8 Predicted protein n=1 Tax=Thalassiosira pseudonana RepID=B8BYF8_THAPS Length = 370 Score = 210 bits (534), Expect = 6e-53, Method: Composition-based stats. Identities = 69/328 (21%), Positives = 119/328 (36%), Gaps = 56/328 (17%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 AK ID IA+ R E+ +V AG+ AP L +L ++PA++ Y KAC G Sbjct: 15 AKKIDAGDIAKPFREEIRNQVAKLKQAGIDAPLLVGLLANTDPAAKKYAEWTGKACRADG 74 Query: 63 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGI-------DNVKVLERIH 115 + + ++ + N D + GI+V P+ + + + + + Sbjct: 75 IRYELRMIDDPI---DVEAALCDANDDPRVHGIIVYYPIFGQVESFSGESQDDYLRDTVS 131 Query: 116 PDKDVDGFHPYNVGRLCQR---------APRLRPCTPRGIVTLLER----------YNID 156 DV+G L + + PCT +V +LE Sbjct: 132 HKCDVEGLCHQYRSNLYRNVRYMDRNHTKKCVLPCTALSVVKILESCESCYDKSKPIGRH 191 Query: 157 TFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNL--------------RHHVEN 202 G +I S IVGRP++ L G + L V Sbjct: 192 MEGQTVTIINRSEIVGRPLAAMLANDGADVYSIDIDSIYLFRGGKLHKCEGETPESCVRK 251 Query: 203 ADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASY-ITPVP 260 + ++I V + +P +WIK V++V + +V ++ + P+ Sbjct: 252 STVVITGVPTKNYRLPSEWIKPNTTVVNVASFK--------NVNEDEILQIEGVQYIPM- 302 Query: 261 GGVGPMTVATLIENTLQACVEYHDPQDE 288 VG +TVA L N ++ +H P + Sbjct: 303 --VGKVTVAMLERNLMRLFYNFHHPDRQ 328 >UniRef50_D1Z754 Whole genome shotgun sequence assembly, scaffold_7 n=2 Tax=Sordariaceae RepID=D1Z754_SORMA Length = 386 Score = 206 bits (524), Expect = 8e-52, Method: Composition-based stats. Identities = 75/329 (22%), Positives = 126/329 (38%), Gaps = 59/329 (17%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 K+I TIA+++ SEV + + P LA L +P++ Y +K CEE Sbjct: 53 TCKVILSDTIAKKLLSEVRETLAKIQGPDASKPTLAAFLATDDPSALQYAEWSKKTCEEN 112 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLP--AGIDNVKVLERIHPDKD 119 GF ++ +L E I N D+ +DGILV P+ + + E + KD Sbjct: 113 GFNFDLRK----VNKEDLEESIIAANNDDNVDGILVYYPIWVGNHSQDKYIKETVALSKD 168 Query: 120 VDGFHPYNVGRLCQR----------APRLRPCTPRGIVTLLER---------YNIDTFGL 160 V+G ++ + + PCTP IV LE Y FG Sbjct: 169 VEGLCHTHLFNMYHNVRFLDPPANLKKSILPCTPLAIVKTLEYLQIYNPILAYGNRLFGK 228 Query: 161 NAVVIGASNIVGRPMSMELLLAGCTTTVT----------------------HRFTKNLRH 198 VI S + GRP++ L G T + L+ Sbjct: 229 TITVINRSEVNGRPLAALLANDGATVYSVDVTGVQVFTRGEGIRQLRHQVHDKEGWELKD 288 Query: 199 HVENADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYIT 257 + +D++I V F +P + +++GA+ I+ + +G ++AS Sbjct: 289 VLPLSDVVIGGVPTEKFKVPTELLRDGAVCINFSSFKNFDG--------PAVKEKASIYV 340 Query: 258 PVPGGVGPMTVATLIENTLQACVEYHDPQ 286 P +G +T+A L+ N ++ P+ Sbjct: 341 P---SIGKVTIAVLLRNLVRLIANRPRPE 366 >UniRef50_A9EVL6 Methylenetetrahydrofolate dehydrogenase (NAD(+)) n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9EVL6_SORC5 Length = 324 Score = 205 bits (521), Expect = 2e-51, Method: Composition-based stats. Identities = 74/318 (23%), Positives = 119/318 (37%), Gaps = 56/318 (17%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A ++D +A+ RSE+ ++ A L VL + S Y RKACE+V Sbjct: 24 TASVLDPTAVAETFRSEIRAELAALPE----PLVLVGVLAADHGPSYTYAEYTRKACEDV 79 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G + + E I N D + G++V P+ +V + + + P KD++ Sbjct: 80 GVRFEIRH----ATRLDAEEAIRAANEDARVHGMMVYYPIFGTEQDVYLRDSVDPAKDIE 135 Query: 122 GFHPYNVGRLCQRA---------PRLRPCTPRGIVTLLERYNI------DTFGLNAVVIG 166 G H + L Q + PCTP I+ L+E G + Sbjct: 136 GLHTFWARCLYQNQRFLDEAKTRKAILPCTPLAILKLVEAAGFFGEGERPLEGRRVCIFN 195 Query: 167 ASNIVGRPMSMELLLAGCTTTVTH-------------------RFTKNLRHHVENADLLI 207 S +VGRP++ + G T T + + AD+++ Sbjct: 196 RSEVVGRPLASMMAHDGAHVTSFDIDGPLLFVPSSSGDMHEVRETTVDRATALRQADIVV 255 Query: 208 VAVGKPGF--IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGP 265 V F + G I+EGA+ I+ + + +D +AS P VGP Sbjct: 256 TGVPSRSFPVVQGAEIREGALCINFSTFKNFS---------DDIQSKASVFVP---RVGP 303 Query: 266 MTVATLIENTLQACVEYH 283 MTV I N+L+ H Sbjct: 304 MTVTMAIRNSLRLYKNTH 321 >UniRef50_Q7NAE4 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Mycoplasma gallisepticum RepID=FOLD_MYCGA Length = 283 Score = 202 bits (514), Expect = 1e-50, Method: Composition-based stats. Identities = 72/281 (25%), Positives = 140/281 (49%), Gaps = 14/281 (4%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 +DG ++Q+++ ++A+KV + + +++ + AS+IYV +K C+ +G + Sbjct: 5 LDGTKLSQKLKEDLAKKV------NNQKIKILIIISDPSEASRIYVRNKINYCDSLGIQT 58 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHP 125 YDL + + + ++ + + +G+LVQLP+ +D K++E I DVD F Sbjct: 59 EVYDLSKIDDTNQFIVEMNQKISLSNPNGVLVQLPIKERLDTNKIIENIPIRLDVDAFLY 118 Query: 126 YNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCT 185 + + + ++ PC ++ L + Y + ++IG +P+ L Sbjct: 119 HRFDQ--DQKEKVIPCVLNAVLELFKEYQLSFLDKKILLIGNGITSNQPIVNYLNEHQIK 176 Query: 186 -TTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGK----- 239 +T ++ L + ADL+I AVGK F+ K G I ID+GI++ + + Sbjct: 177 FDLITKENSQLLEEKTKVADLVISAVGKAKFLANYQFKRGVIFIDIGIDKYFDPEQSKYL 236 Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACV 280 + GD ++ + ASY TP PGG+GP+T+ +L++N + Sbjct: 237 ICGDFDYDKLKEIASYGTPTPGGIGPLTIYSLVKNLINLSE 277 >UniRef50_Q02046 Methylenetetrahydrofolate dehydrogenase [NAD+] n=46 Tax=Ascomycota RepID=MTD1_YEAST Length = 320 Score = 200 bits (509), Expect = 5e-50, Method: Composition-based stats. Identities = 72/324 (22%), Positives = 129/324 (39%), Gaps = 60/324 (18%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARI-AAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 + I +A+ +E+ V+ + P L L ++PA+++Y +K E + Sbjct: 5 GRTILASKVAETFNTEIINNVEEYKKTHNGQGPLLVGFLANNDPAAKMYATWTQKTSESM 64 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 GF + + L E I N D++++GI+V P+ + + + + +KDV+ Sbjct: 65 GFRYDLRVIE---DKDFLEEAIIQANGDDSVNGIMVYFPVFGNAQDQYLQQVVCKEKDVE 121 Query: 122 GFHPYNVGRLCQR---------APRLRPCTPRGIVTLLERYNI---------DTFGLNAV 163 G + L + PCTP IV +LE I +G + Sbjct: 122 GLNHVYYQNLYHNVRYLDKENRLKSILPCTPLAIVKILEFLKIYNNLLPEGNRLYGKKCI 181 Query: 164 VIGASNIVGRPMSMELLLAGCTTTVTH-----RFTKN--------------------LRH 198 VI S IVGRP++ L G T +FT+ L+ Sbjct: 182 VINRSEIVGRPLAALLANDGATVYSVDVNNIQKFTRGESLKLNKHHVEDLGEYSEDLLKK 241 Query: 199 HVENADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYIT 257 ++D++I V + P ++IKEGA+ I+ + + +D ++AS Sbjct: 242 CSLDSDVVITGVPSENYKFPTEYIKEGAVCINFACTKNFS---------DDVKEKASLYV 292 Query: 258 PVPGGVGPMTVATLIENTLQACVE 281 P+ G +T+A L+ N L+ Sbjct: 293 PMT---GKVTIAMLLRNMLRLVRN 313 >UniRef50_UPI000194D930 PREDICTED: methylene tetrahydrofolate dehydrogenase 2 n=1 Tax=Taeniopygia guttata RepID=UPI000194D930 Length = 299 Score = 200 bits (508), Expect = 7e-50, Method: Composition-based stats. Identities = 101/260 (38%), Positives = 127/260 (48%), Gaps = 59/260 (22%) Query: 26 RIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDT 85 +AAG R P L+VVLVG NPAS YV +K KA +VG S + P + SE ELLELI Sbjct: 68 WVAAGNRRPHLSVVLVGENPASHSYVLNKTKAAADVGISSETILRPASISEEELLELIAK 127 Query: 86 LNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRG 145 LN+D +DG+LVQLPLP ID +V + P KDVDGFH NVGR+C + P TPRG Sbjct: 128 LNSDAAVDGLLVQLPLPEHIDERRVCNAVSPHKDVDGFHVLNVGRMCLDQDSMLPATPRG 187 Query: 146 IVTLLERYNIDTFGLNAVVIGASNIVGRPMSM---ELLLAGCTTTVTHRFTKNLRHHVEN 202 + +++R I S + RP S+ ELL Sbjct: 188 VWEIIQRTGIS-----------SETILRPASISEEELLELIAKLNSD-----------AA 225 Query: 203 ADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGG 262 D L+V + PG K+ASYITPVPGG Sbjct: 226 VDGLLVQLPLPG----------------------------------VRKKASYITPVPGG 251 Query: 263 VGPMTVATLIENTLQACVEY 282 VGPMTVA L++NT+ A + Sbjct: 252 VGPMTVAMLMKNTIIAAKKR 271 >UniRef50_C4QVL0 NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase n=14 Tax=Saccharomyceta RepID=C4QVL0_PICPG Length = 389 Score = 197 bits (501), Expect = 4e-49, Method: Composition-based stats. Identities = 64/304 (21%), Positives = 118/304 (38%), Gaps = 58/304 (19%) Query: 8 GKTI-AQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSR 66 GKTI A + + ++++ + + P L +L +PA++ Y + CE +GF Sbjct: 81 GKTILASTIAKKYSEELTSVTSKMATKPKLVGLLGNQDPAAKTYAEWTARTCESLGFQYE 140 Query: 67 SYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPY 126 P+ L + I N D+ ++GI+V P+ + + + + +KDV+G + Sbjct: 141 LIQCPK----ENLEDEIYKCNQDDAVNGIMVYFPVYNDGQDQYLQQCVSIEKDVEGLNFK 196 Query: 127 NVGRLCQR----------APRLRPCTPRGIVTLLER---------YNIDTFGLNAVVIGA 167 V + + PCTP +V +LE Y FG ++ Sbjct: 197 YVSNMYHNIRYLDAPENTKKSILPCTPLAMVKILEYLGVYNTLLPYGNRLFGKTITIVNR 256 Query: 168 SNIVGRPMSMELLLAGCTTTVTHRFTKN---------------------LRHHVENADLL 206 S IVGRP++ L G T L+ +D++ Sbjct: 257 SEIVGRPLAALLANDGATVYSVDINNVQKFERGDGLQLKSHRVVDTEFELKDVAPKSDVI 316 Query: 207 IVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGP 265 I V + P +++K+GA+VI+ + + ++ AS P +G Sbjct: 317 ITGVPSSNYKFPLEYVKDGAVVINFSSEKNFDDRI---------KDIASLYVP---SIGK 364 Query: 266 MTVA 269 +T+A Sbjct: 365 VTIA 368 >UniRef50_Q6UB35 Monofunctional C1-tetrahydrofolate synthase, mitochondrial n=54 Tax=cellular organisms RepID=C1TM_HUMAN Length = 978 Score = 195 bits (496), Expect = 1e-48, Method: Composition-based stats. Identities = 62/282 (21%), Positives = 114/282 (40%), Gaps = 18/282 (6%) Query: 11 IAQQVRSEVAQKVQARIAAGL-RAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYD 69 I ++V + + P LA++ G + Q + EE G Sbjct: 74 IVREVIQNSKEVLSLLQEKNPAFKPVLAIIQAGDDNLMQ---EINQNLAEEAGLNITHIC 130 Query: 70 LPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVG 129 LP +SEAE+++ I +N D + G+ +Q + + + KVL + P+KDVDG N+G Sbjct: 131 LPPDSSEAEIIDEILKINEDTRVHGLALQ--ISENLFSNKVLNALKPEKDVDGVTDINLG 188 Query: 130 RLCQRA--PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTT 187 +L + + ++ LLE+ ++ G +V+GA + + G T Sbjct: 189 KLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTM 248 Query: 188 VTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGD--VV 245 T+ L+ + AD++++ KP IP WI+ G V++ + L G + Sbjct: 249 SIQWKTRQLQSKLHEADIVVLGSPKPEEIPLTWIQPGTTVLNCSHDFLSGKVGCGSPRIH 308 Query: 246 FEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQD 287 F + I + A I+N + + + Q Sbjct: 309 FGGLIEEDDVIL--------LAAALRIQNMVSSGRRWLREQQ 342 >UniRef50_Q86KU6 Methylenetetrahydrofolate dehydrogenase [NAD+] n=1 Tax=Dictyostelium discoideum RepID=MTD1_DICDI Length = 313 Score = 191 bits (487), Expect = 2e-47, Method: Composition-based stats. Identities = 65/315 (20%), Positives = 113/315 (35%), Gaps = 60/315 (19%) Query: 7 DGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSR 66 D IA R EV Q++ P + L + + Y + AC++ G Sbjct: 16 DVTPIANFFREEVKQQI----TKNCWKPRVVAFLTSDDQGAIDYSKWTKLACQKDGIEFI 71 Query: 67 SYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPY 126 +L +LI N D+ + GILV P+ G+ + + + + P KD++G Sbjct: 72 LKR----VERVDLEDLIIEANNDSCVHGILVYYPVFGGMMDSYLQDVVSPTKDIEGLSTQ 127 Query: 127 NVGRLCQR----------APRLRPCTPRGIVTLLERYNI---------DTFGLNAVVIGA 167 N L + PCTP +V +++ I G ++ Sbjct: 128 NRFNLYHNIRFMDGETATKKCVIPCTPLAMVKIIDNLGIYDKSLAMGEHLKGKTVTIVNR 187 Query: 168 SNIVGRPMSMELLLAGCTTTVTH-------------------RFTKNLRHHVENADLLIV 208 S IVGRP++ L G + +D+LI+ Sbjct: 188 SEIVGRPLAAMLANDGAIVYSIDINGIIIFQSGKRHGTIKMSETNVTREEAISKSDILIL 247 Query: 209 AVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMT 267 V P + + D I++G IVI+ G + +++ + S + P +G +T Sbjct: 248 GVPSPNYKVNSDLIQDGTIVINFA----------GCLNVDESIQEKSILVPT---IGKVT 294 Query: 268 VATLIENTLQACVEY 282 +A L N L+ Sbjct: 295 IAMLERNLLRLFNNQ 309 >UniRef50_Q4PBA5 Putative uncharacterized protein n=3 Tax=Basidiomycota RepID=Q4PBA5_USTMA Length = 607 Score = 191 bits (486), Expect = 2e-47, Method: Composition-based stats. Identities = 80/390 (20%), Positives = 121/390 (31%), Gaps = 122/390 (31%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 62 K+I IA + + + +QARI G P L +L +P S Y RKACE VG Sbjct: 222 GKLIQASGIAAPYQDAIKEAIQARIQQGKSRPKLVGILATPSPPSVAYAEWTRKACEAVG 281 Query: 63 FVSRSYD----------------LPETTSEAELLELIDTLNADNTIDGILVQLPLPAGID 106 + P+ EA++ +LI NAD + GI+V P+ G Sbjct: 282 IEFEIWKTWDDSVEVKEEDHKGSAPDFDLEADVEDLIIAANADEKVHGIMVYYPIFFGRQ 341 Query: 107 NVKVLERIHPDKDVDGFHPYNVGRLCQR-------------------------------- 134 + + + + P KDV+G H + Sbjct: 342 DTYLQQIVDPRKDVEGLHFSYCWNMYHNVRWISPAKLGNAPGTTRELPEERASREALDGE 401 Query: 135 ------APRLRPCTPRGIVTLLE---------RYNIDTFGLNAVVIGASNIVGRPMSMEL 179 A + PCTP +V LE Y +G VI S +VGRP++ L Sbjct: 402 QVPPGMAKSILPCTPLAMVKCLEAIGVYDRDLPYGDRLYGKTITVINRSEVVGRPLAALL 461 Query: 180 LLAGCTTTVTHRFTKN-------------------------------------------- 195 G + Sbjct: 462 SNDGAKVYSVDIDSIQEFNKRAVEPSSEPQGRARSEIVKEARAQNTASQLRPHHVVRNCS 521 Query: 196 --LRHHVENADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKR 252 + +D++I V + I +WIK GA+ ++ + D R Sbjct: 522 MTAEECIRASDVVIAGVPSANYKIETEWIKPGAVCVNFSSEKNFKS---------DVRTR 572 Query: 253 ASYITPVPGGVGPMTVATLIENTLQACVEY 282 AS P +G T+A L N L+ Sbjct: 573 ASMYLP---AIGKTTIAMLQRNLLRLVEYR 599 >UniRef50_B0CXH2 Predicted protein n=1 Tax=Laccaria bicolor S238N-H82 RepID=B0CXH2_LACBS Length = 308 Score = 191 bits (486), Expect = 2e-47, Method: Composition-based stats. Identities = 77/317 (24%), Positives = 121/317 (38%), Gaps = 63/317 (19%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 ++ I+ R EV + ++A + P L +L S+ S Y RK CEE+GF Sbjct: 9 LLKADPISAAFRDEVKKDLEACSSR----PKLVGILATSSAPSNNYAEFTRKQCEELGFE 64 Query: 65 SRSYDLPETTSE-----AELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKD 119 S + E I N D+++ GI+V P+ + + + + P KD Sbjct: 65 FVLKKTGAALSSDLAAGEGVEEAIIDANEDDSVHGIMVYYPIFGVQQDHYLQQVVSPLKD 124 Query: 120 VDGFH---PYNVGRLCQRAPR----LRPCTPRGIVTLLER---------YNIDTFGLNAV 163 V+G H YN+ + P + PCTP IV LE Y +G Sbjct: 125 VEGLHFKFHYNLYHKYEPPPGTVKSIIPCTPLAIVKCLEFVGVYNTILPYGDRAYGKTIT 184 Query: 164 VIGASNIVGRPMSMELLLAGCTT-----------------------TVTHRFTKNLRHHV 200 VI S +VGRP++ L G + H L + Sbjct: 185 VINRSEVVGRPLAALLANDGARVLSVDIDSIHVPYFSTLAQKYHPRHIVHPSNLTLEECL 244 Query: 201 ENADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFE-DAAKRASYITP 258 +D+++ AV P + + +K+G I ++V D FE D +AS P Sbjct: 245 AISDVVVSAVPSPSYKVKTALLKDGCICLNVAS----------DKNFEKDVRDKASLYIP 294 Query: 259 VPGGVGPMTVATLIENT 275 VG +T+ L+ N Sbjct: 295 ---AVGKVTILMLLRNL 308 >UniRef50_C7HUG7 Bifunctional protein FolD protein n=1 Tax=Anaerococcus vaginalis ATCC 51170 RepID=C7HUG7_9FIRM Length = 263 Score = 191 bits (485), Expect = 3e-47, Method: Composition-based stats. Identities = 63/251 (25%), Positives = 118/251 (47%), Gaps = 5/251 (1%) Query: 18 EVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEA 77 E+ + I + L ++ ++ A Y + + C E + + E Sbjct: 8 EIKNDILKNIKYCNKKKSLLIISQNNDLAVNQYKNAIIRRCNEFNIDYIDKEFSK---ED 64 Query: 78 ELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPR 137 L++I+ N IDG +V PL D + E I P D+DGF ++G++ + Sbjct: 65 NHLDIINYCNNLKNIDGFIVLQPLLESTDLDYLRENI-PFNDLDGFKYDSLGKIMSKKFE 123 Query: 138 LRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLR 197 P T + I+ + N+D G + ++ ++NI+G+P++M L + T+ + TKN + Sbjct: 124 NLPQTVKSIIKFINYMNLDLEGKDIIIANSTNIIGKPLAMYLNYKKASVTLFNSKTKNQK 183 Query: 198 HHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYIT 257 ++N D+ I A+GK + D+ + G I+ID G++ + +G + GD+ +E I Sbjct: 184 EKIKNCDIFISAIGKANYYNKDYFRNGQIIIDAGVSFV-DGNMYGDIDYEYIKDLDIKIV 242 Query: 258 PVPGGVGPMTV 268 GVG +T Sbjct: 243 TCKNGVGSITT 253 >UniRef50_Q9XYB0 PugilistDominant (Fragment) n=2 Tax=Eukaryota RepID=Q9XYB0_DROME Length = 268 Score = 190 bits (483), Expect = 5e-47, Method: Composition-based stats. Identities = 69/176 (39%), Positives = 97/176 (55%), Gaps = 4/176 (2%) Query: 3 AKIIDGKTIAQQVRSEVAQKVQAR-IAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 AKII G +A+ +R E+ +V A PGL +V VG S +Y+ K KA E+ Sbjct: 4 AKIISGTAVAKSIREELRNEVTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEI 63 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAG--IDNVKVLERIHPDKD 119 G + LP + +E ELL+ I+ LN D + GI+VQ+PL ID+ ++ + + P+KD Sbjct: 64 GIDAAHVQLPRSITEVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKD 123 Query: 120 VDGFHPYNVGRLCQRA-PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRP 174 VDG H N GRL PCTP G + L+ R ++ G AVV+G S IVG P Sbjct: 124 VDGLHTVNEGRLAIGDLGGFLPCTPWGCLELIRRSGVEIAGARAVVLGRSKIVGTP 179 >UniRef50_C7RD94 Tetrahydrofolate dehydrogenase/cyclohydrolase n=3 Tax=Anaerococcus RepID=C7RD94_ANAPD Length = 260 Score = 187 bits (476), Expect = 3e-46, Method: Composition-based stats. Identities = 62/260 (23%), Positives = 115/260 (44%), Gaps = 6/260 (2%) Query: 17 SEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSE 76 E+ + ++ + L ++ Y S K CEE + + S Sbjct: 7 DEIKNSLIDKLGSHKFTNKLLLLSKNPTSEVLYYKKSIIKRCEEFDIEYVDCEFDKE-SP 65 Query: 77 AELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAP 136 E+L I+T + + DG ++ P G D + + I D+D F G + + Sbjct: 66 EEILAFINTFDKE---DGYIILAPFGEGKDLTFLKDNIEIR-DLDAFTYKAQGHTMEGST 121 Query: 137 RLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNL 196 P T R IV LE G + V+ + +G+P++M L+ T T+ R T + Sbjct: 122 ERLPQTARAIVRFLEDKYSSLKGKHIVISNKTTTIGKPLAMNLVTKYATVTMITRHTADQ 181 Query: 197 RHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYI 256 ++ ++N+D+ I A+G+ F + ++G +V+DVG L +GK+VGD+ + + Sbjct: 182 KNIIKNSDIFISAIGRANFYDRSYFRDGMLVVDVGTTYL-DGKIVGDIDYGSLEDVDIEV 240 Query: 257 TPVPGGVGPMTVATLIENTL 276 G+G +T L+E+ + Sbjct: 241 LTNKRGIGALTTLMLLESLI 260 >UniRef50_Q4S6Y9 Chromosome 14 SCAF14723, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4S6Y9_TETNG Length = 1066 Score = 183 bits (465), Expect = 5e-45, Method: Composition-based stats. Identities = 57/278 (20%), Positives = 108/278 (38%), Gaps = 22/278 (7%) Query: 13 QQVRSEVAQKVQARIAAGL-RAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLP 71 ++V + + P LA++ G + + +K +G L Sbjct: 1 REVIEVTKEMITVLQRRNPAIRPSLAIIQAGEDDG---LLEINKKMARRIGLNVTQICLA 57 Query: 72 ETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRL 131 + SE E++ + L+ D + G+ + LP + +VL + P+KDVDG N G L Sbjct: 58 KECSEIEIVTEVLKLSEDPGVHGLYLHLPQAS--LTSRVLTALKPEKDVDGLSDLNTGCL 115 Query: 132 CQRA--PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVT 189 + P ++ L ++++ G +++G + + G V+ Sbjct: 116 IRGDLSAGFVPPVTSAVLEWLSKHHVTLEGKTVLILGGHGTFEVTLRCLIERQGIEVVVS 175 Query: 190 HRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDA 249 +KNL+ V AD ++V +P W K GA+V + E Sbjct: 176 DWTSKNLKSQVMRADAVVVLEAGKKNLPPTWFKPGALVFSCDPTSKTD---------ESV 226 Query: 250 AKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQD 287 A+ +S G+G +T A ++N Q+C + Q+ Sbjct: 227 AESSSN-----SGLGYLTAAYRMKNVAQSCGRWLQEQE 259 >UniRef50_A6QZK7 Putative uncharacterized protein n=1 Tax=Ajellomyces capsulatus NAm1 RepID=A6QZK7_AJECN Length = 297 Score = 183 bits (465), Expect = 7e-45, Method: Composition-based stats. Identities = 62/298 (20%), Positives = 106/298 (35%), Gaps = 56/298 (18%) Query: 11 IAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDL 70 +A V + +V AP L L S+PA+++Y K C++ F Sbjct: 17 LAANVARGLLAEVNEGRQTLSTAPHLVGFLANSDPAAKMYADWTEKTCKDNNFRYTLR-- 74 Query: 71 PETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGR 130 T S ++ + I N+D +DGI+V P+ + + + + KDV+G + Sbjct: 75 --TVSRDDIEDAILVANSDPDVDGIIVYYPIFNNRQDQYLQQIVDISKDVEGLSHRYIFN 132 Query: 131 LCQR----------APRLRPCTPRGIVTLLER---------YNIDTFGLNAVVIGASNIV 171 + Q + PCTP ++ +LE Y FG V+ S +V Sbjct: 133 MYQNIRFLDPPENKQKSILPCTPLAVIKILEYLQIYNTILPYGNRLFGHTICVVNRSEVV 192 Query: 172 GRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWI-KEGAIVIDV 230 GRP++ L G G F G+ I K V+D+ Sbjct: 193 GRPLAALLANDGACVYSVD------------------VTGVQQFTRGEGIRKRHHEVMDM 234 Query: 231 GINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQDE 288 N + ++AS P +G +T+ L+ N L+ + + Sbjct: 235 EGNFGP-----------EVKEKASIYVP---AIGKVTIVVLLRNLLRIVQNRSRNRVQ 278 >UniRef50_B7G8Y9 Predicted protein (Fragment) n=8 Tax=Eukaryota RepID=B7G8Y9_PHATR Length = 274 Score = 176 bits (446), Expect = 1e-42, Method: Composition-based stats. Identities = 60/287 (20%), Positives = 99/287 (34%), Gaps = 54/287 (18%) Query: 34 PGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTID 93 P L +L +PA++ Y KAC G L + ++ + N D + Sbjct: 1 PLLVGLLANKDPAAKKYAEWTGKACRADGLRYELRVLDDPI---DVEAALMDANDDPRVH 57 Query: 94 GILVQLPLPAG-------IDNVKVLERIHPDKDVDGFHPYNVGRLCQR----------AP 136 GI+V P+ + + + + DV+G L + Sbjct: 58 GIIVYYPIFGQEESFSGASQDDYLRDSVSFKCDVEGLCHTYRTNLYRNVRYLDYPSNTEK 117 Query: 137 RLRPCTPRGIVTLLER----------YNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTT 186 L PCT +V +LE G VI S IVGRP++ L G Sbjct: 118 CLLPCTALSVVKILEECPGCYDMTRPLGKRNEGKTITVINRSEIVGRPLAAMLSNDGADV 177 Query: 187 TVTHRFTKNL-------------RHHVENADLLIVAVGKPGF-IPGDWIKEGAIVIDVGI 232 + L V + ++I V + +P +WI+E V++V Sbjct: 178 YSVDVNSIYLFTGGRLHKVDETPESCVRKSSVIITGVPTKSYRLPTEWIQEHTTVVNVSS 237 Query: 233 NRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 + + E+A + + VP VG +TVA L N ++ Sbjct: 238 FKNVD---------EEALLKIPGVVYVPL-VGKVTVAMLERNLMRLY 274 >UniRef50_Q5KEZ0 Methylenetetrahydrofolate dehydrogenase (NAD+), putative n=2 Tax=Agaricomycotina RepID=Q5KEZ0_CRYNE Length = 367 Score = 175 bits (445), Expect = 1e-42, Method: Composition-based stats. Identities = 80/372 (21%), Positives = 122/372 (32%), Gaps = 105/372 (28%) Query: 1 MA-AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACE 59 M+ +I +A +SE+ + + + R P L +L ++ Y +KACE Sbjct: 1 MSQGILITASKVATPFKSELLSALASPRFSS-RPPHLVGILATKKEDARTYAEFTKKACE 59 Query: 60 EVGFVSRSYDLPETTSEA--------ELLELIDTLNADNTIDGILVQLPLPAGIDNVKVL 111 +G L E E+ E I N D +DG++V P+ G + + Sbjct: 60 TLGITYEL-RLVGEAREGMDGEGVGIEVEEAILEANEDPEVDGMMVYYPIYGGRQDQYLQ 118 Query: 112 ERIHPDKDVDGFHPYNVGRLCQRA------------------------------------ 135 + P KDV+G + + L Sbjct: 119 SVVSPQKDVEGLNHQFLFNLYHNVRFINPLTLRPIPASHLPEPLPSKSGDSSKGEDVAPE 178 Query: 136 ---PRLRPCTPRGIVTLLER---------YNIDTFGLNAVVIGASNIVGRPMSMELLLAG 183 + PCTP IV +LE Y G VI S +VGRP++ L G Sbjct: 179 GTVKSILPCTPLAIVKVLEHIGVYNRLLAYGDRARGKVITVINRSEVVGRPLAALLANDG 238 Query: 184 CTTTVT---------------------------HRFTK----NLRHHVENADLLIVAVGK 212 H T L + +D++I AV Sbjct: 239 ARVISVDLDSIVEFSKRPSKSAEGKKPSSASPHHITTPLPDMTLHKALSFSDVVISAVPV 298 Query: 213 PGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFE-DAAKRASYITPVPGGVGPMTVAT 270 F +P +K+G + ++V G+ FE D RAS P VG MT+ Sbjct: 299 DSFKVPTRELKDGCVCVNVA----------GEKNFETDVRDRASIYVP---SVGVMTITM 345 Query: 271 LIENTLQACVEY 282 L N L+ C Sbjct: 346 LQRNLLRLCEYR 357 >UniRef50_D0NPK1 Methylenetetrahydrofolate dehydrogenase [NAD+], putative n=12 Tax=Phytophthora infestans T30-4 RepID=D0NPK1_PHYIN Length = 471 Score = 175 bits (443), Expect = 2e-42, Method: Composition-based stats. Identities = 70/335 (20%), Positives = 116/335 (34%), Gaps = 84/335 (25%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVS 65 ++ TIA+ V Q ++ G P L V KAC G Sbjct: 156 MNAATIAEPFSLAVRQYIE--QDMGGVGPKLVEVR-----------RGTGKACARDGIRY 202 Query: 66 RSYDLPETTSEAELLELIDTLNADNTIDGILVQLP-------LPAGIDNVKVLERIHPDK 118 ++P+ ELLE ++ N D+ + GILV P G + + + I K Sbjct: 203 ELREVPKD----ELLEALEKANKDSDVHGILVYYPCFGAFPSFFGGTMDDFLRDSISIKK 258 Query: 119 DVDGFHPYNVGRLCQR---------APRLRPCTPRGIVTLLERYNI---------DTFGL 160 DV+G + G L + + PCT IV +LE + G+ Sbjct: 259 DVEGLCQFYRGNLYRNMRYVDDEKTQKCVLPCTHLAIVKILEHLGVYDKTKPTGDHLSGV 318 Query: 161 NAVVIGASN------------------IVGRPMSMELLLAGCTTTVTHRFTKNL------ 196 N V+ S+ IVGRP++ L G ++ L Sbjct: 319 NITVVSRSDIVTANVPYSFTCRGRVSYIVGRPLAAMLANDGADVYSADIYSLYLFRRGKL 378 Query: 197 -------RHHVENADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFED 248 + + ++I V + +P +W+ E ++I+V + + E Sbjct: 379 IPSEETQETACKKSRVIITGVPVKSYKLPLEWVSENTVIINVASFKNVD-------EAEL 431 Query: 249 AAKRASYITPVPGGVGPMTVATLIENTLQACVEYH 283 + P+ VG +TVA L N L+ +H Sbjct: 432 LKIKGVQYVPL---VGKVTVAMLERNLLRLYENFH 463 >UniRef50_B8NT34 Methylenetetrahydrofolate dehydrogenase, putative n=2 Tax=Aspergillus RepID=B8NT34_ASPFN Length = 307 Score = 173 bits (440), Expect = 5e-42, Method: Composition-based stats. Identities = 64/311 (20%), Positives = 114/311 (36%), Gaps = 58/311 (18%) Query: 13 QQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPE 72 + ++ + + L VL + S Y RK C+E+G L Sbjct: 12 DDLAKRAHSQISEILTNTPKRLFLMGVLASDDAGSNQYANWTRKTCQEIGVHFHLMKL-- 69 Query: 73 TTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLC 132 S + I +NA+N++ GI+V P+ + ++ + + P KDV+G + + R+ Sbjct: 70 --SPKNVATYIRAINANNSVHGIIVYYPIFGDRRDDEIRQLVAPSKDVEGLNHQTLHRIS 127 Query: 133 QRAP---------RLRPCTPRGIVTLLERYNID---------TFGLNAVVIGASNIVGRP 174 A + PCTPR + +LE ++ +I S +VG P Sbjct: 128 DAAEVSRPPKPGRNVIPCTPRAVAWILEWMDVHDRTRPAGERLQNQEICIINRSEVVGLP 187 Query: 175 MSMELLLAGCTTTVTHR------------------FTKNLRHH-----VENADLLIVAVG 211 ++ L G K+L + V+ + ++I AV Sbjct: 188 LAHLLAGEGARVYSVDISGVQLFQRLYYPWQSEALHGKDLPNWSVQDAVQRSRVVISAVP 247 Query: 212 KPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVAT 270 P F + W++ GAI ++V + VV + AS P VG +T+ Sbjct: 248 DPAFRVNTKWLQRGAICVNVSSEKNFEANVV---------EVASKFVP---RVGSVTIGA 295 Query: 271 LIENTLQACVE 281 L+ N + Sbjct: 296 LLYNLILCSSR 306 >UniRef50_B5GAQ6 Tetrahydrofolate dehydrogenase/cyclohydrolase n=1 Tax=Streptomyces sp. SPB74 RepID=B5GAQ6_9ACTO Length = 333 Score = 168 bits (427), Expect = 2e-40, Method: Composition-based stats. Identities = 85/285 (29%), Positives = 126/285 (44%), Gaps = 32/285 (11%) Query: 6 IDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLV----GSNP-------ASQIYVASK 54 + G + + VR +A A +G G+AVV +P AS++ K Sbjct: 7 LSGNALLRSVRENLAMYRDAIEPSGK---GIAVVRFTPTDSDSPEWVRRMEASRVSANQK 63 Query: 55 RKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERI 114 KA +GF LP T S AE + ID NAD+ I I+VQ P PA + +++R+ Sbjct: 64 VKAFSYLGFTVDHLVLPGTVSAAEFADRIDAFNADDHIRAIIVQFPPPARL--TPLVQRL 121 Query: 115 HPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDT-FGLNAVVIGASNIVGR 173 KD+DG L R+P T GI ++ I + V+GA VGR Sbjct: 122 EQIKDIDGL-------LEDRSPHRACATADGISRVV----IPVAEEASIAVVGARGFVGR 170 Query: 174 PMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGA-IVIDVGI 232 + L G + +AD+++ GKP + D IK +V+D G Sbjct: 171 GVVRLLKDHGLDV--IPLDIGDDLRRAAHADIVVSTAGKPHILTPDHIKPHHRLVVDSGF 228 Query: 233 NRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 L +G V GD+ A ITPVPGGVGP+ +A L++ ++ Sbjct: 229 TPLPDGTVAGDI-HPAATYIPQNITPVPGGVGPIEMAVLMDRIIR 272 >UniRef50_Q0UVW9 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum RepID=Q0UVW9_PHANO Length = 292 Score = 166 bits (421), Expect = 8e-40, Method: Composition-based stats. Identities = 64/306 (20%), Positives = 113/306 (36%), Gaps = 68/306 (22%) Query: 11 IAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDL 70 +A + + ++V+ ++ R P L L S+PA+++Y K C E GF ++ Sbjct: 12 LANNIAKSLLEEVRDGLSKIERKPLLVGFLSSSDPAARVYAEWTGKTCTENGFAFDLREV 71 Query: 71 PETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGR 130 E L++ N D+ I + DKDV+G + Sbjct: 72 DRELLEDALIDA----NNDDKI---------------------VSIDKDVEGLSHRYIFN 106 Query: 131 LCQR---------APRLRPCTPRGIVTLLER---------YNIDTFGLNAVVIGASNIVG 172 + Q + PCTP ++ +LE Y G VI S +VG Sbjct: 107 MYQNIRFLDPANTKKSILPCTPLAVIKILEYLRIYNTILPYGNRLHGRTITVINRSEVVG 166 Query: 173 RPMSMELLLAGCTTTVTH-----RFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIV 227 RP++ L G FT+ + +++ KPG+ D + +V Sbjct: 167 RPLAALLANDGACVYSVDISDVQEFTRGVGLRKRRHEVV----DKPGWTLDDCLPLSDVV 222 Query: 228 ID--------VGINRLENGKVVGDVVFE-----DAAKRASYITPVPGGVGPMTVATLIEN 274 I V + ++ +G V + E + ++AS P +G +T+A L+ N Sbjct: 223 ISGVPGDKYKVPLEKMRDGAVCINFSSERNFTPEVKEKASIYVP---AIGKVTIAVLLRN 279 Query: 275 TLQACV 280 L + Sbjct: 280 LLVSLQ 285 >UniRef50_B1AIX6 Methylenetetrahydrofolate dehydrogenase n=15 Tax=Ureaplasma RepID=B1AIX6_UREP2 Length = 269 Score = 163 bits (413), Expect = 6e-39, Method: Composition-based stats. Identities = 51/234 (21%), Positives = 91/234 (38%), Gaps = 10/234 (4%) Query: 49 IYVASKRKACEEVGFVSRSYDLPETTSEAE--LLELIDTLNADNTIDGILVQLPLPAGID 106 Y+ SK K + YDL + L + N D + + PL Sbjct: 41 AYIQSKLKYAKLFSVKLIIYDLNAYQIQENHHFLSKLKQANKD----FLFFEFPLSKKHL 96 Query: 107 NVKVLERIHPDKDVDGFH-PYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVI 165 + + + D+DG + + + + P T I+TL++ +++ +I Sbjct: 97 DQNYFQYLTFQNDLDGINSHLFLNKKQENQIIYHPATINAILTLIKELDVNLNDYRICII 156 Query: 166 GASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGA 225 G S +G + L + H TKN ++ ++ +I V K + + + + Sbjct: 157 GRSPYLGDYLYKLLNPKNNKINIIHSQTKNPLRIIKESNFIISCVNKAHIFNSNALSDNS 216 Query: 226 IVIDVGINRLENGKVVGD--VVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 +IDV + N K+ G + DA R TPVPGG+G +T L N + Sbjct: 217 YLIDVTTEYI-NNKLCGSFLINKNDALNRNIKYTPVPGGIGKLTTLFLFLNYFK 269 >UniRef50_UPI000023D48A hypothetical protein FG10624.1 n=1 Tax=Gibberella zeae PH-1 RepID=UPI000023D48A Length = 302 Score = 161 bits (409), Expect = 2e-38, Method: Composition-based stats. Identities = 64/296 (21%), Positives = 122/296 (41%), Gaps = 39/296 (13%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 +A+++ G + + + + + G P +AVV + + YV K Sbjct: 17 SARLLTGDLVVRDIE----RWCDRKADKGGVKPVMAVVYFNTGADAIDYVKIKAHVAARA 72 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G Y++P S +++ + LN + I GIL+Q PLP ++ +V+ I+P K+++ Sbjct: 73 GVSYWVYEMPVDASTTQVMTQVKKLNKNPRIHGILIQRPLPRQLNEPEVMRSINPIKNIE 132 Query: 122 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 181 + + +V LL +Y + A IVG Sbjct: 133 EYAKGRANNIA----------ADALVRLLTKYGLRESAQQA----RIQIVG--------- 169 Query: 182 AGCTTTVTHRFTKNLRHHVENAD-------LLIVAVGK-PGFIPGDWIK-EGAIVIDVGI 232 +T F K ++ + ++I + + PGFI +K E ++++D+G Sbjct: 170 --FGNIITKEFIKQMKSQFPYMEVEAPRDSIIISELHRGPGFIKSSMVKSEVSVLVDLGF 227 Query: 233 NRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQDE 288 E G V+GDV + + I P PGGV P+ + ++E T++A + + Sbjct: 228 YVTEKG-VLGDVSHVLFDRSSLAIAPTPGGVLPILLWIMMERTIKAKNLTMKEEMQ 282 >UniRef50_A8ZN24 Putative uncharacterized protein n=1 Tax=Acaryochloris marina MBIC11017 RepID=A8ZN24_ACAM1 Length = 482 Score = 155 bits (393), Expect = 1e-36, Method: Composition-based stats. Identities = 60/239 (25%), Positives = 101/239 (42%), Gaps = 17/239 (7%) Query: 40 LVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQL 99 L+ A++ K K + +G +L +T+ E L+ +N + ++VQ Sbjct: 46 LLAKYEAARFSTEHKVKTFKALGCEVEHLNLDASTTSVEFGRLLKHVNKKSI--SVIVQN 103 Query: 100 PLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFG 159 P P D L I +KD+DG N T I ++E + + Sbjct: 104 PFPE--DFKSWLSEISYEKDIDGLRRDN-------PFFRVSATSETIFRIVEPFAQE--N 152 Query: 160 LNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGD 219 V+GA VG ++ L +G + + + A++++ A+G P + Sbjct: 153 DVVAVVGAEGFVGGGVTRLLEESGISVIGLDKN--DDLTLTRQANIVVSAMGSPNELDER 210 Query: 220 WI-KEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 I E +V+D G L + ++GDV A ITPVPGGVGP +ATL+E ++ Sbjct: 211 HIIPEHRLVVDSGFIPLADSPILGDVN-RSAYDIPLNITPVPGGVGPFQMATLMERLVR 268 >UniRef50_B8BT80 Methylenetetrahydrofolate dehydrogenase (Fragment) n=1 Tax=Thalassiosira pseudonana CCMP1335 RepID=B8BT80_THAPS Length = 266 Score = 152 bits (384), Expect = 2e-35, Method: Composition-based stats. Identities = 52/271 (19%), Positives = 91/271 (33%), Gaps = 49/271 (18%) Query: 50 YVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNV- 108 Y +C G + + +P ++ L I N + G+LV P+ + + Sbjct: 3 YSEQILTSCTADGIIYEPWRVPP--TKDALERAIHHANERLDVHGVLVFYPIYDKLLDDV 60 Query: 109 -------KVLERIHPDKDVDGFHPYNVGRLCQRAPR---------LRPCTPRGIVTLLER 152 + + P KDV+G+ + + + PCT + +LE Sbjct: 61 YYKSMDCYFRDLVSPHKDVEGYCRKALRMKQPGSNEGGDHSLYGPIYPCTALAVYRILES 120 Query: 153 -YNID--TFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRF----------------T 193 + ID +I S ++G P++ L G T T Sbjct: 121 LHAIDRRFDKTTITIINRSEVLGIPLATMLSNQGATVYSVDINSILQFSPDGKIRREPST 180 Query: 194 KNLRHHVENADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKR 252 + V + ++ V F +P +WI + V++V + E Sbjct: 181 TTVETCVRQSSAVVSGVPSTEFLVPTEWISDNTTVVNVATES--------NFDEETIYNV 232 Query: 253 ASYITPVPGGVGPMTVATLIENTLQACVEYH 283 +T VP VG +TVA L N + YH Sbjct: 233 PG-VTYVPH-VGRVTVAALEYNLICLHRNYH 261 >UniRef50_B6WAQ3 Putative uncharacterized protein n=1 Tax=Anaerococcus hydrogenalis DSM 7454 RepID=B6WAQ3_9FIRM Length = 164 Score = 151 bits (382), Expect = 2e-35, Method: Composition-based stats. Identities = 47/158 (29%), Positives = 88/158 (55%), Gaps = 1/158 (0%) Query: 119 DVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSME 178 D+DGF ++G++ + + P T R I+ ++ +ID G + ++ ++N++G+P+SM Sbjct: 5 DLDGFRYDSLGKIMDKNFKNLPQTARSIIKFIDYMDIDLKGKDVIIANSTNVIGKPLSMY 64 Query: 179 LLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 L T T+ + T N + ++ AD+ I A+GK F D+ ++G ++ID G + + +G Sbjct: 65 LNYKKATVTLFNSKTINQKEKIKRADIFISAIGKANFYNVDYFRDGQVLIDAGTSFI-DG 123 Query: 239 KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 K+ GD+ ++ I GVG +T +LIE L Sbjct: 124 KMYGDIDYDSLENLKVDIVTCKNGVGSITTLSLIETLL 161 >UniRef50_B5Y3N3 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B5Y3N3_PHATR Length = 365 Score = 150 bits (378), Expect = 7e-35, Method: Composition-based stats. Identities = 63/319 (19%), Positives = 114/319 (35%), Gaps = 60/319 (18%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNP---ASQIYVASKRKACEEV 61 ++D +AQ +R +V LA VL + P S++Y + E Sbjct: 60 VVDVSDLAQSMREQVRAYTARVAPE---RVHLAGVLARNGPHRSDSEVYAERIAETLESD 116 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G Y+ +++ ++I +N + + GILV P+ + + P KDV+ Sbjct: 117 GIDFTLYECIGE-KPSDVSKVIREMNGRSDVHGILVFYPIFKKNSPMYGRRKGPPLKDVE 175 Query: 122 GF-HPYNV-------GRLCQRAPRLRPCTPRGIVTLLERYNI-----------DTFGLNA 162 G H YN GR PCT ++ +L+ Y+ G Sbjct: 176 GLGHNYNARWIFRARGRNRMEREVYIPCTALAVMKILQTYHPLESSVAEAQHKRWAGFRV 235 Query: 163 VVIGASNIVGRPMSMELLLAGCTTTVTH---------------RFTKNLRHHVENADLLI 207 ++ S I+GRP++ L L G + R L + + +++ Sbjct: 236 TIVNRSEILGRPLAALLALEGASVYSVDDSSILEFMDGGRMRLRNDLTLNECLRQSAIVV 295 Query: 208 VAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITP----VPGG 262 V + +P D I V+++ + + + A TP +P Sbjct: 296 TGVPSEDYCLPCDMILPETTVVNIS-------------EYANVDEAAVIHTPHIRLIPQ- 341 Query: 263 VGPMTVATLIENTLQACVE 281 +G +TVA L +N + Sbjct: 342 IGKVTVAALEQNLILLHQR 360 >UniRef50_Q3M1J6 Tetrahydrofolate dehydrogenase/cyclohydrolase n=3 Tax=Nostocaceae RepID=Q3M1J6_ANAVT Length = 396 Score = 148 bits (373), Expect = 3e-34, Method: Composition-based stats. Identities = 60/285 (21%), Positives = 107/285 (37%), Gaps = 30/285 (10%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAA-GLRAPGLAVVLVGSNP-----------ASQIYVA 52 +IDG Q +R V Q+ Q + +A++ ++ A++I Sbjct: 3 LIDG----QLIREHVKQECQKYKSIFQASQKEVAIIRFEASENASNGLRARYEAARISAE 58 Query: 53 SKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLE 112 K +G L + + +I ++N ++ + +VQ P+PA + Sbjct: 59 QKVATFNAIGITPNYIVLSPNIAVEQFDNIIQSINENSKVTAAIVQYPIPAKFTTS--IG 116 Query: 113 RIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVG 172 + P KD+D + R T GI ++E Y + V Sbjct: 117 LLEPQKDID------IVRRQSNNFFESCATAEGIARIVESYAQSDSNVAVV---GGGGFV 167 Query: 173 RPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGI 232 ++ L A + +L + AD+++ G+ G + +V+D G Sbjct: 168 GNGVIKYLEASRISCFCLEDGDDL-SRTQAADIVVSVTGRQGIFTPYVLPSHRLVVDGGF 226 Query: 233 NRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQ 277 +G GDV A + ITPVPGGVGP+ +A L E ++ Sbjct: 227 TPTASGA-AGDVD-RSAYRIPQNITPVPGGVGPIEMAILAERLVK 269 >UniRef50_Q5PNN5 Novel protein similar to methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofola (Mthfd1) (Fragment) n=3 Tax=Danio rerio RepID=Q5PNN5_DANRE Length = 263 Score = 141 bits (355), Expect = 3e-32, Method: Composition-based stats. Identities = 44/190 (23%), Positives = 73/190 (38%), Gaps = 10/190 (5%) Query: 11 IAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDL 70 I Q+ R E+ P LA++ G + + +K ++G L Sbjct: 81 IVQRCREELK---SIGENNPGLKPTLAIIQAGEDDG---LLEMNKKMAGKIGLNVMQICL 134 Query: 71 PETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGR 130 P +E E++E + LN D+ + GI + LP + V I P KDVDG NVGR Sbjct: 135 PHRCTEEEVIEEVLRLNKDSRVHGIFLH--LPQTFLSKSVRNAIKPQKDVDGVCDLNVGR 192 Query: 131 LCQRA--PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTV 188 + ++ LL +++ G AV++G + + L G Sbjct: 193 VVLGDKTDGFTSPVAGAVLELLAKHDAPLVGKMAVLVGLEGPLKVALQCLLQNNGMILQT 252 Query: 189 THRFTKNLRH 198 + NL+ Sbjct: 253 CRWSSTNLQK 262 >UniRef50_UPI0000D9A063 PREDICTED: similar to Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor n=1 Tax=Macaca mulatta RepID=UPI0000D9A063 Length = 198 Score = 135 bits (341), Expect = 2e-30, Method: Composition-based stats. Identities = 50/156 (32%), Positives = 68/156 (43%), Gaps = 10/156 (6%) Query: 93 DGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLER 152 G LVQLPL D K+ PDK VD F NVG C + T + +++ Sbjct: 30 HGHLVQLPLAGHTDERKICNAFSPDKGVDDFPVMNVGLKCLDQYSMLLATRWDVRETIKQ 89 Query: 153 YNIDTFGLNAVVIGASNIVGRPMSMELL--------LAGCTTTVTHRFTKN--LRHHVEN 202 ++ VV G S IV P+ M L T ++ ++ N L+ H Sbjct: 90 TDVPILEKTVVVAGRSKIVRMPIVMSLHIDGAHERPRDDATVIISPGYSPNEQLKKHKIF 149 Query: 203 ADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 AD + A G P D IKE A VIDVGI R+++ Sbjct: 150 ADSVTSAAGIPSLFTIDIIKERAAVIDVGITRVQDP 185 >UniRef50_A6BAZ7 Fold bifunctional protein (Ppdc) (Fragment) n=1 Tax=Vibrio parahaemolyticus AQ3810 RepID=A6BAZ7_VIBPA Length = 183 Score = 127 bits (319), Expect = 5e-28, Method: Composition-based stats. Identities = 82/115 (71%), Positives = 94/115 (81%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE 60 M A+ IDG I+Q VRSEVA +V+AR+AAGLRAPGLAVVLVG +PASQ+YV SKR+ACEE Sbjct: 1 MTAQNIDGTLISQTVRSEVAARVKARVAAGLRAPGLAVVLVGEDPASQVYVGSKRRACEE 60 Query: 61 VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIH 115 VGFVS+S+DLP +TSE ELL LID LN DN IDGILVQLPLPAGID V + Sbjct: 61 VGFVSKSFDLPASTSEEELLALIDELNNDNEIDGILVQLPLPAGIDTTHVQSVFN 115 >UniRef50_B4FJK4 Putative uncharacterized protein n=1 Tax=Zea mays RepID=B4FJK4_MAIZE Length = 221 Score = 123 bits (310), Expect = 5e-27, Method: Composition-based stats. Identities = 47/102 (46%), Positives = 61/102 (59%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A IIDGK+IA+ +R +A++V + PGLAVVLVG S+ YV K K CEEV Sbjct: 94 TASIIDGKSIAEDMRLHIAEEVCQMKCSVGHVPGLAVVLVGDRRDSESYVRYKTKGCEEV 153 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPA 103 G S LP SE E+++ + N D ++ GILVQLPLP Sbjct: 154 GIKSLLAKLPGNCSEDEVMDSVSRFNEDPSVHGILVQLPLPE 195 >UniRef50_A4HZR2 Methylenetetrahydrofolate dehydrogenase-like protein n=3 Tax=Leishmania RepID=A4HZR2_LEIIN Length = 475 Score = 120 bits (302), Expect = 5e-26, Method: Composition-based stats. Identities = 48/153 (31%), Positives = 70/153 (45%), Gaps = 22/153 (14%) Query: 156 DTFGLNAVVIGASNIVGRPMSMELLLAG-CTTTVTHRFTKNL---RHHVENADLLIVAVG 211 L+AV++ S +VG P + L AG T+ + +L RH + AD+LI A G Sbjct: 290 PRRDLHAVIVNNSRVVGVPTAALLQCAGSFAVTLC-SRSNSLDTIRHVAQQADVLITAYG 348 Query: 212 KPGFIPGDWIKEGAIVIDVGINRLEN-----------------GKVVGDVVFEDAAKRAS 254 +++EGAIVID +N L + GDV + A+ Sbjct: 349 AANVFDRSFVREGAIVIDAAVNELPEMTCQKEAAAETGGSARKKGICGDVDINSVSAVAA 408 Query: 255 YITPVPGGVGPMTVATLIENTLQACVEYHDPQD 287 IT PGGVGP+T + L+ N L+A HD + Sbjct: 409 AITKTPGGVGPLTASHLMFNVLKAYQLRHDNER 441 Score = 105 bits (263), Expect = 2e-21, Method: Composition-based stats. Identities = 47/134 (35%), Positives = 67/134 (50%), Gaps = 4/134 (2%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 +A+++ G I++++R + R P L VVLVG + YV KR+A E Sbjct: 31 SAELLSGVPISKELRQRIRTSTSVLR----RPPCLVVVLVGDRADAIRYVNHKRRAAAEC 86 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVD 121 G L T + EL + ++N D +D +L+QLPLP + L IHP KDVD Sbjct: 87 GIEVHLVHLSATIQQVELHRTLASVNDDVEVDAVLLQLPLPPHLRTRPALLHIHPGKDVD 146 Query: 122 GFHPYNVGRLCQRA 135 G HP N G LC + Sbjct: 147 GLHPLNAGSLCLQD 160 >UniRef50_UPI00005A5066 PREDICTED: similar to Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor n=1 Tax=Canis lupus familiaris RepID=UPI00005A5066 Length = 239 Score = 116 bits (291), Expect = 8e-25, Method: Composition-based stats. Identities = 49/114 (42%), Positives = 70/114 (61%), Gaps = 11/114 (9%) Query: 175 MSMELLLAGCTTTVTHRFTK--NLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGI 232 ++ LL ++H++T L+ A+++I AVG I D IKEGA +I+VGI Sbjct: 88 LAQHLLQKD---PLSHQYTPKEQLKKCTVLAEIVISAVGILNLITADIIKEGAALINVGI 144 Query: 233 NRLENG-----KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 NR+++ K+VGDV FE K A+YITPV GVGPMTVA L++NT+ A + Sbjct: 145 NRVQDPILSKAKLVGDVDFEGIRKNANYITPV-WGVGPMTVAMLMKNTIIAAKK 197 >UniRef50_B9PLA1 Methylenetetrahydrofolate dehydrogenase, putative n=3 Tax=Toxoplasma gondii RepID=B9PLA1_TOXGO Length = 630 Score = 115 bits (288), Expect = 2e-24, Method: Composition-based stats. Identities = 33/103 (32%), Positives = 57/103 (55%) Query: 136 PRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKN 195 P PC ++ +L+ +++ G V+GAS VG+ +++ LL T + H T++ Sbjct: 354 PFPAPCVALAVLDILKAWDMSLAGAAVAVVGASPRVGQAIALLLLQRQATVCLCHSRTRD 413 Query: 196 LRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 L+ + +D++I A G P I D ++ A VIDVG+N LE+ Sbjct: 414 LKGILLRSDVIIAAAGSPHLISSDMVRPNAAVIDVGVNVLESS 456 Score = 52.6 bits (125), Expect = 2e-05, Method: Composition-based stats. Identities = 18/39 (46%), Positives = 25/39 (64%), Gaps = 1/39 (2%) Query: 240 VVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQA 278 VVGDV + ++ +ITPVP GVG +T A L+ L+A Sbjct: 572 VVGDVDLD-VNRKTKFITPVPQGVGLVTSAVLMRQVLKA 609 >UniRef50_C0Z3J6 AT2G38660 protein n=2 Tax=Arabidopsis thaliana RepID=C0Z3J6_ARATH Length = 185 Score = 113 bits (284), Expect = 5e-24, Method: Composition-based stats. Identities = 45/99 (45%), Positives = 63/99 (63%) Query: 5 IIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFV 64 +IDG IA+++R+++ +V A + PGLAVVLVG SQ YV +K KACEE G Sbjct: 65 VIDGNVIAEEIRTKIISEVGKMKKAVGKVPGLAVVLVGEQRDSQTYVRNKIKACEETGIK 124 Query: 65 SRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPA 103 S +LPE +E +++ ++ N D +I GILVQLPLP Sbjct: 125 SVLAELPEDCTEGQIISVLRKFNEDTSIHGILVQLPLPQ 163 >UniRef50_UPI0001904966 Methenyltetrahydrofolate cyclohydrolase n=2 Tax=Rhizobium etli RepID=UPI0001904966 Length = 175 Score = 113 bits (283), Expect = 7e-24, Method: Composition-based stats. Identities = 47/102 (46%), Positives = 59/102 (57%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 +IDGK +A V V A + GLAV++VG +PAS YV SK + +E Sbjct: 1 MTTVIDGKNVAASVIQTVKSATAALEKSSGVTTGLAVIIVGDDPASHAYVGSKGRMAKEC 60 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPA 103 GF S + LP TS+AEL L+ TLNAD +I GILVQLPL Sbjct: 61 GFKSVQHTLPAETSQAELAALVATLNADPSIHGILVQLPLAE 102 >UniRef50_B6FPJ6 Putative uncharacterized protein n=1 Tax=Clostridium nexile DSM 1787 RepID=B6FPJ6_9CLOT Length = 91 Score = 112 bits (280), Expect = 2e-23, Method: Composition-based stats. Identities = 36/88 (40%), Positives = 55/88 (62%) Query: 198 HHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYIT 257 V AD+++ A+G+ + +W+K+G +VIDV +NR +NGK+ GDV D ++ SYIT Sbjct: 4 EEVRQADIVVSAMGQAKLVKKEWLKQGTVVIDVEMNRDKNGKLCGDVELNDVMEKVSYIT 63 Query: 258 PVPGGVGPMTVATLIENTLQACVEYHDP 285 PV G G +T A L+EN +QA + Sbjct: 64 PVSKGDGFVTRAMLLENIMQAYSGKMNK 91 >UniRef50_A1ZUI3 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZUI3_9SPHI Length = 233 Score = 109 bits (273), Expect = 1e-22, Method: Composition-based stats. Identities = 61/212 (28%), Positives = 97/212 (45%), Gaps = 24/212 (11%) Query: 82 LIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPC 141 +ID+LN D I ++VQ P P G+ ++++++P KD+D R+ P Sbjct: 1 MIDSLNKDTNIGAVIVQSPPPKGL--ENIVKKLNPKKDLDALSGDKKNRMFP-----YPA 53 Query: 142 TPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHH-- 199 T GIV ++E + G VV+G +G + L G + + + Sbjct: 54 TSEGIVRIVEPFA--EAGKKIVVVGGGGFIGEGVITMLKEKGIKPHIIDPRVIDDPGYQG 111 Query: 200 -----VENADLLIVAVGKPGFIPGDWIKEGAIVI-DVGINRLEN------GKVVGDVVFE 247 ++N D++I VGK G I G +K+ +I D G LEN V GDV Sbjct: 112 KDLALMKNYDIIISTVGKEGLIKGKDLKDDHTLIVDTGFVPLENVDKLTSKNVKGDVD-P 170 Query: 248 DAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 A + ++TPVPGG GP+ +A L+E + Sbjct: 171 TAKNKTKFVTPVPGGTGPVEMAVLMERVAKLF 202 >UniRef50_Q6X5D4 Methylene-THF dehydrogenase (Fragment) n=1 Tax=Treponema primitia RepID=Q6X5D4_9SPIO Length = 97 Score = 94.9 bits (235), Expect = 3e-18, Method: Composition-based stats. Identities = 30/98 (30%), Positives = 48/98 (48%), Gaps = 1/98 (1%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A+++DGK +A + + + V+A A P L ++ +G Y K EEV Sbjct: 1 MAQLLDGKVVAAALAESLKKDVEALKAK-GVTPTLGIIRLGEKGPDISYEKGATKRAEEV 59 Query: 62 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQL 99 G ++Y LPE T++ LL++I N D + G L Q Sbjct: 60 GAAVKNYILPEDTTQEALLKVIKEANDDKGVHGCLAQR 97 >UniRef50_D0NV87 Tetrahydrofolate dehydrogenase n=7 Tax=Phytophthora infestans T30-4 RepID=D0NV87_PHYIN Length = 261 Score = 91.5 bits (226), Expect = 3e-17, Method: Composition-based stats. Identities = 29/146 (19%), Positives = 54/146 (36%), Gaps = 24/146 (16%) Query: 152 RYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNL-------------RH 198 + +I+ + V + S IVGRP++ L G + L Sbjct: 123 KSDIEGSVHDIVSVHVSYIVGRPLAAMLANDGADVYSADIDSLYLFRRGKLIPSEETQET 182 Query: 199 HVENADLLIVAVGKPGF-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYIT 257 + + ++I V + +P +W+ E ++I V + + E + Sbjct: 183 ACKKSRVIITGVPVKSYKLPLEWVSENTVIIYVASFKNVD-------DAELLKIKGVQYV 235 Query: 258 PVPGGVGPMTVATLIENTLQACVEYH 283 P+ VG +TVA L N L+ +H Sbjct: 236 PL---VGKVTVAMLERNLLRLYENFH 258 >UniRef50_D0NYB3 Tetrahydrofolate dehydrogenase n=1 Tax=Phytophthora infestans T30-4 RepID=D0NYB3_PHYIN Length = 402 Score = 83.4 bits (205), Expect = 9e-15, Method: Composition-based stats. Identities = 27/130 (20%), Positives = 48/130 (36%), Gaps = 24/130 (18%) Query: 168 SNIVGRPMSMELLLAGCTTTVTHRFTKNL-------------RHHVENADLLIVAVGKPG 214 S IVGRP++ L G + L + + ++I V Sbjct: 275 SYIVGRPLAAMLANDGADVYSADIDSLYLFRRGKLIPSEETQETACKKSRVIITGVPVKS 334 Query: 215 F-IPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIE 273 + +P +W+ E ++I+V + + E + P+ VG +TVA L Sbjct: 335 YKLPLEWVSENTVIINVASFKNVD-------EAELLKIKGVQYVPL---VGKVTVAMLER 384 Query: 274 NTLQACVEYH 283 N L+ +H Sbjct: 385 NLLRLYENFH 394 >UniRef50_B3L796 Putative uncharacterized protein n=2 Tax=Plasmodium (Plasmodium) RepID=B3L796_PLAKH Length = 614 Score = 76.4 bits (187), Expect = 1e-12, Method: Composition-based stats. Identities = 24/129 (18%), Positives = 47/129 (36%), Gaps = 9/129 (6%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARI------AAGLRAPGLAVVLVGSNPASQIYVASK 54 M + G +A Q+ V +K+ + + L ++ N A+ Y+ Sbjct: 1 MNCGTLYGYELASQIDQLVIRKIASGKIQIEGNRNWPQEKTLFIIY-SKNIATYSYLHIL 59 Query: 55 RKACEEVG--FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLE 112 K + + + +E L+ LI +N +++ PL I+ + Sbjct: 60 IKKSLLLNADVTFVMIRVHKGCNEKRLINLIKKINRRGKNTWLIILSPLSRHINKCYISS 119 Query: 113 RIHPDKDVD 121 I +KDVD Sbjct: 120 FISQEKDVD 128 Score = 67.6 bits (164), Expect = 5e-10, Method: Composition-based stats. Identities = 37/184 (20%), Positives = 57/184 (30%), Gaps = 63/184 (34%) Query: 118 KDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGA---------- 167 K + P L PC I+ L+ Y I N +++ + Sbjct: 246 KHISSVSPEIYNYLRNSTKYNFPCCVHAILLFLKYYQIHVKEKNVLILSSNISIFLSLFA 305 Query: 168 -------SNIVGRPM-SMELLLAGCTTTVTHRFTKNLRH--------------------- 198 S V P+ L T + T NL Sbjct: 306 FFFQSEVSTTVYDPLRGHVLCRYDDKTKKCYLRTSNLGKLHIRDKADFKSKCKKFSKFYI 365 Query: 199 ------------------------HVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINR 234 V+N+DL+I+A+G P + +IKEGAI++D+GIN Sbjct: 366 STSKGYTKITHHDLSTLRKNMHTRIVKNSDLIIMAIGCPHILKKKYIKEGAIILDLGINL 425 Query: 235 LENG 238 + G Sbjct: 426 VPPG 429 Score = 51.8 bits (123), Expect = 3e-05, Method: Composition-based stats. Identities = 16/43 (37%), Positives = 27/43 (62%), Gaps = 1/43 (2%) Query: 234 RLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTL 276 L+N ++VGD E+ ++ + I+ VPGG+GP+T + L N Sbjct: 571 FLQNYEIVGDAD-ENCKQKCALISSVPGGLGPITTSMLFYNLY 612 >UniRef50_C6KTE2 Putative uncharacterized protein n=1 Tax=Plasmodium falciparum 3D7 RepID=C6KTE2_PLAF7 Length = 657 Score = 68.0 bits (165), Expect = 4e-10, Method: Composition-based stats. Identities = 28/140 (20%), Positives = 60/140 (42%), Gaps = 10/140 (7%) Query: 1 MAAKIIDGKTIAQQVRSEVAQKVQARIAAGL------RAPGLAVVLVGSNPASQIYVASK 54 M I++G +++++ V +K++ A + R L ++ N S Y+ Sbjct: 1 MNGVILNGHYVSEKIDEFVLEKIKYEDAKNIHSKGWKRKKKLFIIY-SKNIVSYSYLYIL 59 Query: 55 RKACEEVG--FVSRSYDLPETTSEAELLELIDTLNADNTID-GILVQLPLPAGIDNVKVL 111 K + V + + SE +L+++I +N + D +++ PL I+ + Sbjct: 60 LKKSIYLNSDVVFVLIRVNKKVSEEKLIKIIKRININENNDTSLIILSPLSYHINKCYIS 119 Query: 112 ERIHPDKDVDGFHPYNVGRL 131 E I +KD+D + +L Sbjct: 120 EFIQKEKDIDCSNYKTFLKL 139 Score = 53.3 bits (127), Expect = 1e-05, Method: Composition-based stats. Identities = 18/43 (41%), Positives = 27/43 (62%), Gaps = 1/43 (2%) Query: 233 NRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENT 275 N L+N ++GDV + + SYI+ VPGG+GP+T + L N Sbjct: 612 NILKNYVIMGDVDM-NCKNKCSYISSVPGGLGPITTSMLFYNL 653 >UniRef50_C7YLA7 Predicted protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YLA7_NECH7 Length = 269 Score = 62.6 bits (151), Expect = 2e-08, Method: Composition-based stats. Identities = 22/97 (22%), Positives = 42/97 (43%), Gaps = 8/97 (8%) Query: 35 GLAVVLVGSNPASQIYVASKRKACEEVGFV--SRSYDLP---ETTSEAELLELIDTLNAD 89 L ++ + + + +V K+ +++G + LP E+T L + LN + Sbjct: 3 HLVLINLDPSRDTSPHVRFKKDKIQDLGLDLTCVVWTLPQSSESTPIETLRLKLRELNEN 62 Query: 90 NTIDGILVQLPLPAG---IDNVKVLERIHPDKDVDGF 123 + G+ PLP G ID ++ + KDV+G Sbjct: 63 PEVVGVCFISPLPKGLGRIDLGELCLLLDEKKDVEGL 99 >UniRef50_UPI00015563B5 PREDICTED: similar to Mthfd2-prov protein, partial n=1 Tax=Ornithorhynchus anatinus RepID=UPI00015563B5 Length = 161 Score = 56.4 bits (135), Expect = 1e-06, Method: Composition-based stats. Identities = 27/60 (45%), Positives = 41/60 (68%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 61 A +I G+ +A+Q+R EV +V+ +A+G + P L+V+LVG NPAS YV +K KA +V Sbjct: 46 EAVVISGRKLARQIREEVRHEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTKAAADV 105 >UniRef50_A4YD89 Glutamyl-tRNA reductase n=1 Tax=Metallosphaera sedula DSM 5348 RepID=HEM1_METS5 Length = 424 Score = 54.9 bits (131), Expect = 3e-06, Method: Composition-based stats. Identities = 25/108 (23%), Positives = 43/108 (39%), Gaps = 20/108 (18%) Query: 147 VTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCT-TTVTHR---FTKNLR----- 197 V + D G ++GA I G+ +++ L G T T+ +R +NL Sbjct: 169 VEFAKSRFGDILGKKIAILGAGEIGGK-LALILHNEGATDVTIFNRTFERGRNLAIKYGY 227 Query: 198 -------HHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENG 238 + N D++ A+ P + EG +VID+G + G Sbjct: 228 SYFPLDFSRLHNYDIIFSAIFYPEKVKA---PEGTVVIDLGSPPVFEG 272 >UniRef50_Q4YPQ5 Putative uncharacterized protein n=4 Tax=Plasmodium (Vinckeia) RepID=Q4YPQ5_PLABE Length = 666 Score = 51.4 bits (122), Expect = 3e-05, Method: Composition-based stats. Identities = 26/141 (18%), Positives = 55/141 (39%), Gaps = 9/141 (6%) Query: 8 GKTIAQQVRSEVAQKVQARIAAGL-------RAPGLAVVLVGSNPA-SQIYVASKRKACE 59 G I++++ + +K++ L L V+ + A S +Y+ K+ Sbjct: 4 GLPISEKIDQLILKKIENYKKENLENGIELEVKKNLYVIYSKNVVAYSYLYILLKKSIYL 63 Query: 60 EVGFVSRSYDLPETTSEAELLELIDTLNAD-NTIDGILVQLPLPAGIDNVKVLERIHPDK 118 ++ + + S+ +L+ LI +N IL+ PL I+ V + I K Sbjct: 64 KLDINFILVKIDKKYSQEKLINLIKKINKKKGDNTSILILSPLSFHINKFYVSKFISEKK 123 Query: 119 DVDGFHPYNVGRLCQRAPRLR 139 D+D + + ++ L Sbjct: 124 DIDASNNNAIFKVLNIKKSLL 144 Score = 47.5 bits (112), Expect = 5e-04, Method: Composition-based stats. Identities = 16/42 (38%), Positives = 26/42 (61%), Gaps = 1/42 (2%) Query: 234 RLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENT 275 +N ++ GDV + K +S+I+ VPGG+GP+T + L N Sbjct: 607 FFKNYEIFGDVDL-NCRKNSSHISAVPGGIGPITTSMLFYNL 647 >UniRef50_A4FH75 Ornithine/acetylornithine aminotransferase n=6 Tax=Bacteria RepID=A4FH75_SACEN Length = 824 Score = 50.6 bits (120), Expect = 7e-05, Method: Composition-based stats. Identities = 21/110 (19%), Positives = 41/110 (37%), Gaps = 22/110 (20%) Query: 148 TLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTK------------- 194 T++ R + ++G +G M+ LL GC + HR + Sbjct: 141 TVIARLGRRPSDVEVGIVGFPGAIGLAMARLLLDDGCRLHLVHRKGRMRPEQLLDELPAA 200 Query: 195 ---------NLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRL 235 ++ + L++ A G I D ++ G++V+DV + R Sbjct: 201 AHDRVTIGDDVAECLRRTRLIVAASSAGGLIDCDDLRPGSVVVDVALPRD 250 >UniRef50_C8WWK0 Dipicolinic acid synthetase, A subunit n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WWK0_ALIAD Length = 302 Score = 49.9 bits (118), Expect = 9e-05, Method: Composition-based stats. Identities = 29/149 (19%), Positives = 55/149 (36%), Gaps = 28/149 (18%) Query: 141 CTPRGIVTL-LERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNL--- 196 T G + + ++ +I G VV+G G+ ++ +L G V ++L Sbjct: 135 PTAEGAIAIAMQETDITLHGAKTVVLG-FGRCGQTLAHKLHAMGAVVHVCASDPRDLARI 193 Query: 197 -------------RHHVENADLLIVAVGK---PGFIPGDWIKEGAIVIDVGINRLENGKV 240 H V +AD++ + P + +E A++ID+ Sbjct: 194 HEQSLIPVPLKHIEHAVHDADIVFNTIPAMVLPAAVLKRMRRE-AVIIDIASKPGGT--- 249 Query: 241 VGDVVFEDAAKRASYITP-VPGGVGPMTV 268 D + + + +TP +PG V P T Sbjct: 250 --DFRYAERRGIKAILTPSLPGLVAPRTA 276 >UniRef50_D0YQ76 Bifunctional protein FolD 2 (Fragment) n=2 Tax=cellular organisms RepID=D0YQ76_9ACTO Length = 37 Score = 49.1 bits (116), Expect = 2e-04, Method: Composition-based stats. Identities = 15/31 (48%), Positives = 22/31 (70%) Query: 251 KRASYITPVPGGVGPMTVATLIENTLQACVE 281 + A+++TP PGGVGPMT A L+ N ++A Sbjct: 2 RVAAWLTPNPGGVGPMTRALLLVNVVEAAER 32 >UniRef50_Q0IEF9 Putative uncharacterized protein n=1 Tax=Aedes aegypti RepID=Q0IEF9_AEDAE Length = 51 Score = 48.3 bits (114), Expect = 3e-04, Method: Composition-based stats. Identities = 16/42 (38%), Positives = 26/42 (61%), Gaps = 1/42 (2%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGL-RAPGLAVVLVG 42 AK+IDGK IA +R E+ ++++ + G RAP L +L+ Sbjct: 7 MAKLIDGKQIAADIRMELREQIEEWMKQGGNRAPHLTAILME 48 >UniRef50_C1XXU4 Predicted dehydrogenase n=1 Tax=Meiothermus silvanus DSM 9946 RepID=C1XXU4_9DEIN Length = 574 Score = 47.5 bits (112), Expect = 5e-04, Method: Composition-based stats. Identities = 38/166 (22%), Positives = 53/166 (31%), Gaps = 34/166 (20%) Query: 143 PRGIVTL-LERYNIDTFGLNAVVIGASNIVGRPMSME---LLLAGCTTTVTHRFTKNLRH 198 G+V + R G +V + + L G T H T Sbjct: 396 ANGVVAFGIARQIAPLVGKLILVGRNMERLEKSAESLRKNLERKGQTP---HLVTTTDIS 452 Query: 199 HVENADLLIVAVGKPG-FIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYIT 257 + ADL+ A P I + +K GA + D G+ DV ED K Sbjct: 453 AIREADLIFTATSDPKAVIRPEHVKPGAWIYDEGVPP--------DVD-EDVKKIPGVRV 503 Query: 258 PVPGGV----GPMT------------VATLIENTLQACVEYHDPQD 287 +PGGV G MT A L E + A +D + Sbjct: 504 -IPGGVVRPPGNMTGNLDLHFGQGAVPACLAETMILAAERAYDRKS 548 >UniRef50_B5Y9H6 Shikimate / quinate 5-dehydrogenase domain protein n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5Y9H6_COPPD Length = 352 Score = 47.5 bits (112), Expect = 6e-04, Method: Composition-based stats. Identities = 37/170 (21%), Positives = 52/170 (30%), Gaps = 30/170 (17%) Query: 114 IHPDKDVD-GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVG 172 I K +D G N L + ID V+GA+ +G Sbjct: 111 ISIAKALDIGVTTGNSYTAYTAGEALLLAA--------KEVGIDPKSCTLTVVGATGSIG 162 Query: 173 RPMSMELLLAGCTTTVTHR------------------FTKNLRHHVENADLLIVAVGKPG 214 ++ L + R +T N+ V ADLLI P Sbjct: 163 SVLTKVLAPQVGRVILVARNMDRLQSLAEVLKNYDVDYTSNVSEGVRKADLLITVSSAPE 222 Query: 215 -FIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGV 263 I + ++ GAIV+DV R V D + VPG V Sbjct: 223 AIIDAEDLQPGAIVVDVSRPRNVAESVA--KKRSDVLVLDGGVVRVPGDV 270 >UniRef50_B1I1H2 Shikimate/quinate 5-dehydrogenase n=22 Tax=Clostridia RepID=B1I1H2_DESAP Length = 371 Score = 47.2 bits (111), Expect = 7e-04, Method: Composition-based stats. Identities = 34/176 (19%), Positives = 57/176 (32%), Gaps = 34/176 (19%) Query: 141 CTP-RGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRF------- 192 T +G + V+GA+ +G + L T+ R Sbjct: 136 ATAIQGAREAARLMGHNLAEAEVAVVGAAGAIGSVCARILAREAKRMTLVGRNQQKLELV 195 Query: 193 --------------TKNLRHHVENADLLIVAV-GKPGFIPGDWIKEGAIVIDVGINRLEN 237 T +L + AD+++ I + +K GA+V DV R + Sbjct: 196 ADSILADCGLAARITSDLAGALRRADVVVTVTSAVDTIIEPEHLKPGAVVCDVARPRDVS 255 Query: 238 GKVVGDVVFEDAAKRASYITPVPGGV------G---PMTVATLIENTLQACVEYHD 284 +VV V +D + VPG V G M A + E + A + + Sbjct: 256 RRVV--EVRDDVLVIEGGVVEVPGPVDFHLNFGFPPRMAYACMAETMILALEKRFE 309 >UniRef50_C3YVA9 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae RepID=C3YVA9_BRAFL Length = 511 Score = 46.8 bits (110), Expect = 8e-04, Method: Composition-based stats. Identities = 32/161 (19%), Positives = 53/161 (32%), Gaps = 28/161 (17%) Query: 136 PRLRPCTPRGIVTLLERY-NIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHR--- 191 L C ++ L+R +I G + VV G VG+ L G VT Sbjct: 270 DNLYSC-RESVLDALKRTTDIMFGGKHVVVCGYGE-VGKGCCSALRGLGAIVCVTEIDPI 327 Query: 192 ----------FTKNLRHHVENADLLIVAVGKPGFIPGDWI---KEGAIVIDVGINRLENG 238 L + D++I A G + D + K G +V ++G + E Sbjct: 328 CALQASMEGFKVVTLNEVIRQVDVVITASGNKNVVTRDHLDRMKTGCVVCNMGHSNTE-- 385 Query: 239 KVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 279 + + + VP V +T AT ++ Sbjct: 386 -----IDVGRLVNLS--CSSVPSFVVSITAATQALALIELF 419 >UniRef50_B0PHV3 Putative uncharacterized protein n=2 Tax=Bacteria RepID=B0PHV3_9FIRM Length = 295 Score = 46.0 bits (108), Expect = 0.002, Method: Composition-based stats. Identities = 36/166 (21%), Positives = 62/166 (37%), Gaps = 30/166 (18%) Query: 142 TPRGIVTL-LERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHR--------- 191 T G V + +E I FG +++G + R + L G + TV R Sbjct: 136 TAEGAVAIAMEELPIALFGSRCLIVG-HGRIARALIRILRGMGASVTVAARSYGSLAEIE 194 Query: 192 -------FTKNLRHHVENADLLIVAVGKPGFIPG--DWIKEGAIVIDVGINRLENGKVVG 242 T L+ V+ AD++I V +K A+VID+ G Sbjct: 195 AEGCRAVRTDALKTSVKAADVVINTVPARMLTEPVLSALKHDALVIDLASRP-------G 247 Query: 243 DVVFEDAAK---RASYITPVPGGVGPMTVATLIENTLQACVEYHDP 285 V A + + + +PG P+T +I +T++ C+ + Sbjct: 248 GVDLAAAGRLGVKTIWALSLPGKTAPITAGEIILHTIENCLSELEE 293 >UniRef50_C8W3U8 Shikimate/quinate 5-dehydrogenase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8W3U8_DESAS Length = 370 Score = 45.6 bits (107), Expect = 0.002, Method: Composition-based stats. Identities = 30/132 (22%), Positives = 44/132 (33%), Gaps = 24/132 (18%) Query: 154 NIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHH-------------- 199 D + V+IGA+ +G+ + L T+ R T L Sbjct: 144 GYDICQADIVIIGATGSIGKVCARYLAREVKNLTLVARDTSKLEEIAAKILFDYGLAVKV 203 Query: 200 -------VENADLLIVAV-GKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAK 251 + AD++I I +K GA+V DV R + KV +D Sbjct: 204 TPYSRSALRKADVIITVTSAVDTIIGPGDLKPGAVVCDVSRPRNVSKKVA--EERDDVLV 261 Query: 252 RASYITPVPGGV 263 I VP GV Sbjct: 262 IEGGIVEVPHGV 273 >UniRef50_B3DT49 S-adenosylhomocysteine hydrolase n=10 Tax=Bifidobacteriaceae RepID=B3DT49_BIFLD Length = 500 Score = 45.6 bits (107), Expect = 0.002, Method: Composition-based stats. Identities = 25/127 (19%), Positives = 45/127 (35%), Gaps = 30/127 (23%) Query: 148 TLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRF-------------TK 194 +L + D G N VIG VG+ + + G T+ + Sbjct: 275 RILGEHAFD--GKNVTVIGYGP-VGQGFARRIRALGAEVTICDIDPVASLKAVFDGFAAQ 331 Query: 195 NLRHHVENADLLIVAVGKPGFIPGDWIK---EGAIVIDVGINRLENGKVVGDVVFEDAAK 251 ++ + AD+++ A G + + ++ EGA + V+G + E A Sbjct: 332 DIDEALPCADMVVSATGVRHTVTLEHMRAMHEGAAL-----------AVIGGIANEIALD 380 Query: 252 RASYITP 258 S TP Sbjct: 381 EVSDFTP 387 >UniRef50_B1Z0C8 Short-chain dehydrogenase/reductase SDR n=4 Tax=Bacteria RepID=B1Z0C8_BURA4 Length = 266 Score = 45.6 bits (107), Expect = 0.002, Method: Composition-based stats. Identities = 19/89 (21%), Positives = 34/89 (38%), Gaps = 9/89 (10%) Query: 154 NIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKP 213 +++ G +V G++ +G ++ L G T V H + + V A + VA G Sbjct: 2 DLNLRGKRVLVTGSTAGLGEAIAKLLAAEGATV-VVHGRSSDRAEAVAAA--ITVAGGHA 58 Query: 214 GFIPGDWIKEGAIVIDVGINRLENGKVVG 242 + G + D G N + G Sbjct: 59 E------VALGDLATDAGANAVVAKATEG 81 >UniRef50_C3Y6A1 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae RepID=C3Y6A1_BRAFL Length = 1329 Score = 44.8 bits (105), Expect = 0.003, Method: Composition-based stats. Identities = 23/87 (26%), Positives = 38/87 (43%), Gaps = 5/87 (5%) Query: 142 TPRGIVTL---LERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRH 198 T RG++T L + G AVV GAS+ +G ++ L AG + R L+ Sbjct: 1068 TQRGVLTCNKKLRAASGPLAGKVAVVTGASSGIGASTALYLARAGAQVVLVARRVDRLQQ 1127 Query: 199 HVE--NADLLIVAVGKPGFIPGDWIKE 223 + A+ + VGK + +K+ Sbjct: 1128 LQKDVEAEGGVAIVGKADVVNRKEVKD 1154 >UniRef50_Q8SU39 Similarity to HYPOTHETICAL OXIDOREDUCTASE YAEB_SCHPO n=1 Tax=Encephalitozoon cuniculi RepID=Q8SU39_ENCCU Length = 299 Score = 44.8 bits (105), Expect = 0.003, Method: Composition-based stats. Identities = 24/92 (26%), Positives = 35/92 (38%), Gaps = 8/92 (8%) Query: 138 LRPCTPRGIVTLL---ERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTK 194 L T I ++ R+ I G ++IG S+ +G + L AG TVT R K Sbjct: 6 LVLATVVAIYFMIGYSARHGISIRGRKILIIGGSSGLGLAFARILKEAGNDVTVTSRSMK 65 Query: 195 NLRHHVEN----ADLL-IVAVGKPGFIPGDWI 221 L +L + A P D+I Sbjct: 66 KLEALQRRWGLKTQVLDVNAADVPEPTDFDYI 97 >UniRef50_C6M1U6 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase n=2 Tax=Neisseriaceae RepID=C6M1U6_NEISI Length = 253 Score = 44.8 bits (105), Expect = 0.003, Method: Composition-based stats. Identities = 18/69 (26%), Positives = 29/69 (42%), Gaps = 3/69 (4%) Query: 155 IDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPG 214 ++ A VIGAS+ +GR + + L G + R T L A L+ G+ Sbjct: 5 LNLKNKTAAVIGASSGIGRAVVLLLAEHGANVVLCARRTDKLEET---AALIRSRGGRAV 61 Query: 215 FIPGDWIKE 223 + GD + Sbjct: 62 AVAGDAVLP 70 >UniRef50_B5IQA9 Glycerate dehydrogenase n=1 Tax=Cyanobium sp. PCC 7001 RepID=B5IQA9_9CHRO Length = 315 Score = 44.8 bits (105), Expect = 0.003, Method: Composition-based stats. Identities = 21/96 (21%), Positives = 41/96 (42%), Gaps = 12/96 (12%) Query: 146 IVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTK--NLRHHVENA 203 + L+E + G + V+GA +I GR ++ G T T L + A Sbjct: 145 VFALVEPAFDELAGRHLTVVGAGDI-GRGVAAVGDAFGMTVHPITSRTPAQELEVALRQA 203 Query: 204 DLL-----IVAVGKPGFIPGD---WIKEGAIVIDVG 231 D++ + A + I + W+K A+++++G Sbjct: 204 DVVSLHAPLTAASR-HLINAERLAWMKASAVLVNMG 238 >UniRef50_C6P544 Biotin/acetyl-CoA-carboxylase ligase n=1 Tax=Sideroxydans lithotrophicus ES-1 RepID=C6P544_9PROT Length = 330 Score = 44.5 bits (104), Expect = 0.004, Method: Composition-based stats. Identities = 31/122 (25%), Positives = 41/122 (33%), Gaps = 19/122 (15%) Query: 162 AVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWI 221 A + G S VG M L G L + + A +LI A G D + Sbjct: 153 AALSGLSLAVGVAMMRALAELGVQGVGLKWPNDVLLNDGKLAGILIEAQG-------DML 205 Query: 222 KEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVE 281 A+VI VGIN + G + + AS PVP N + A Sbjct: 206 GPSAVVIGVGINLTVPEALRGRID-QQVTDLASLGAPVP-----------ERNLVLAVSL 253 Query: 282 YH 283 H Sbjct: 254 KH 255 >UniRef50_C2M1R4 Putative uncharacterized protein n=1 Tax=Capnocytophaga gingivalis ATCC 33624 RepID=C2M1R4_CAPGI Length = 835 Score = 44.5 bits (104), Expect = 0.004, Method: Composition-based stats. Identities = 20/134 (14%), Positives = 44/134 (32%), Gaps = 19/134 (14%) Query: 20 AQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRK-------ACEEVGFVSRSYDLPE 72 + + P ++ +P S Y SK + ++ + + L E Sbjct: 554 KAETETGYKETNYIPHKPIIPTKKDPVSTSY-RSKEEVIRLCNFFANKINIEFKLHSLNE 612 Query: 73 TTSEAELLE---LIDTLNADNTIDGILVQLPLPAGID----NVKVLERIHP----DKDVD 121 + E ++ +I + I I QL + I+ +L I P +++ + Sbjct: 613 EVAPKEYIDRGEIIFDFRRNPEILSIYNQLKEKSSINGYKPYESILILITPEDEQEENSE 672 Query: 122 GFHPYNVGRLCQRA 135 G N + + Sbjct: 673 GVSHKNKTHIYENN 686 >UniRef50_Q3ACY7 Dipicolinate synthase, A subunit n=1 Tax=Carboxydothermus hydrogenoformans Z-2901 RepID=Q3ACY7_CARHZ Length = 302 Score = 44.5 bits (104), Expect = 0.004, Method: Composition-based stats. Identities = 38/161 (23%), Positives = 56/161 (34%), Gaps = 33/161 (20%) Query: 139 RPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRH 198 P I +E I G NA VIG G+ ++ L G V R K+L Sbjct: 135 IPSAEGAIQMAMEMIPITIHGSNAFVIGFGRT-GQTLARMLAGIGARVFVAARKPKDLAR 193 Query: 199 H----------------VENADLLIVAVGK----PGFIPGDWIKEGAIVIDVGINRLENG 238 + AD++ V + +K+ A++ID+ N Sbjct: 194 IYEQCYIPVTFKELEVKIVEADIVFNTVPALVLPANLLQK--LKKDAVIIDLASNP---- 247 Query: 239 KVVGDVVFEDAAK--RASYITP-VPGGVGPMTVATLIENTL 276 G V FE A + + P +PG V P T L+ L Sbjct: 248 ---GGVDFEAAKSLGIQAVLAPGLPGKVAPKTAGKLLAKVL 285 >UniRef50_B9J9W2 Adenosylhomocysteinase protein n=6 Tax=Bacteria RepID=B9J9W2_AGRRK Length = 388 Score = 44.5 bits (104), Expect = 0.005, Method: Composition-based stats. Identities = 25/103 (24%), Positives = 35/103 (33%), Gaps = 17/103 (16%) Query: 150 LERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRF-------------TKNL 196 L N T G V G G+ + A +V T Sbjct: 184 LRFTNRSTNGKRVAVFGYGAC-GKGTAACFRNAFSAVSVVDIDPVTTLEAHLDGFGTPLR 242 Query: 197 RHHVENADLLIVAVGKPGFIPGDW---IKEGAIVIDVGINRLE 236 + +AD+LI G P I IK+GAI+++ G LE Sbjct: 243 DEGIRSADILITVTGYPAIITATDLPLIKDGAILMNGGHFPLE 285 >UniRef50_A8L9A5 S-adenosyl-L-homocysteine hydrolase n=1 Tax=Frankia sp. EAN1pec RepID=A8L9A5_FRASN Length = 377 Score = 44.1 bits (103), Expect = 0.005, Method: Composition-based stats. Identities = 21/104 (20%), Positives = 41/104 (39%), Gaps = 14/104 (13%) Query: 138 LRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRF----- 192 + P + L+ + FGLNA ++G VGR ++ L G + +V Sbjct: 168 IGPSVAFSVEKLVRAMGVPLFGLNAGILGYGR-VGRNLAYSLAGRGSSVSVYDSDPLRRI 226 Query: 193 --------TKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVI 228 + + V+ +D+++ A G + D+ + VI Sbjct: 227 SAAADGFQSVSRESVVQTSDIIVGATGNTSLVEMDFPQLKHRVI 270 >UniRef50_O29376 S-adenosylhomocysteinase hydrolase (AhcY-1) n=1 Tax=Archaeoglobus fulgidus RepID=O29376_ARCFU Length = 326 Score = 44.1 bits (103), Expect = 0.005, Method: Composition-based stats. Identities = 24/102 (23%), Positives = 45/102 (44%), Gaps = 13/102 (12%) Query: 142 TPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRF-TKNLRHHV 200 T G++ L R N+ G A+++G VGR + L GC V T+ + Sbjct: 135 TAFGLLDALLRLNVFLPGKKALILG-FGRVGRGCARLLKSVGCDVAVWDNDETRQIEALY 193 Query: 201 E--------NADLLIVAVGKPGFIPG---DWIKEGAIVIDVG 231 E A++++ G G + + I +G+I++++G Sbjct: 194 EGFRVEKDFTAEVVVTCTGVKGVLGKEELEEISDGSIILNMG 235 >UniRef50_A6NPY8 Putative uncharacterized protein n=1 Tax=Bacteroides capillosus ATCC 29799 RepID=A6NPY8_9BACE Length = 256 Score = 43.3 bits (101), Expect = 0.009, Method: Composition-based stats. Identities = 28/121 (23%), Positives = 42/121 (34%), Gaps = 20/121 (16%) Query: 141 CTPRGIVTL-LERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRF------- 192 T G + + +E I G +VIG VGR + G +V+ R Sbjct: 137 PTAEGAIQIAMEELPITIHGARVLVIGYGR-VGRMTAQRFQALGAKVSVSARKYADLAWA 195 Query: 193 ---------TKNLRHHVENADLLIVAVGKPGFIPGD--WIKEGAIVIDVGINRLENGKVV 241 T L + DL+I V + +K G +VID+ G+ V Sbjct: 196 ESLGLGVEQTGRLLGWLCGYDLVINTVPARVLGEAELGDLKPGCLVIDLASKPGGAGERV 255 Query: 242 G 242 G Sbjct: 256 G 256 >UniRef50_A5MC89 Putative uncharacterized protein n=1 Tax=Streptococcus pneumoniae SP14-BS69 RepID=A5MC89_STRPN Length = 65 Score = 42.9 bits (100), Expect = 0.012, Method: Composition-based stats. Identities = 15/41 (36%), Positives = 24/41 (58%) Query: 2 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVG 42 +IIDGK +A +++ ++A+K PGL V+LVG Sbjct: 1 MTQIIDGKALAAKLQGQLAEKTAKLKEETALVPGLVVILVG 41 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.313 0.154 0.433 Lambda K H 0.267 0.0475 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 1,952,569,875 Number of Sequences: 3077464 Number of extensions: 88455784 Number of successful extensions: 267066 Number of sequences better than 1.0e-01: 250 Number of HSP's better than 0.1 without gapping: 649 Number of HSP's successfully gapped in prelim test: 134 Number of HSP's that attempted gapping in prelim test: 264683 Number of HSP's gapped (non-prelim): 882 length of query: 288 length of database: 1,040,396,356 effective HSP length: 127 effective length of query: 161 effective length of database: 649,558,428 effective search space: 104578906908 effective search space used: 104578906908 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 93 (40.2 bits)