Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	N	T	K	L	L	L	A	I	A	T	S	A	A	L	L	T	G	C	Q	N	T	H	G	I	D	T	N	M	A	I	S	S	G	L	N	A	Y	K	A	A	T	L	S	D	A	D	A	K	A	I	A	N	Q	G	C	A	E	M
Secondary structure
SS confidence
Disorder		?	?	?	?																?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	S	G	N	Q	V	A	S	K	S	S	K	Y	G	K	R	L	A	K	I	A	K	A	L	G	N	N	I	N	G	T	P	V	N	Y	K	V	Y	M	T	S	D	V	N	A	W	A	M	A	N	G	C	V	R	V	Y	S	G	L	M
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?	?	?																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		D	M	M	N	D	N	E	I	E	G	V	L	G	H	E	L	G	H	V	A	L	G	H	S	L	A	E	M	K	A	S	Y	A	I	V	A	A	R	D	A	I	S	A	T	S	G	V	A	S	Q	L	S	R	S	Q	L	G	D	I	A
Secondary structure
SS confidence
Disorder																																													?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	G	A	I	N	A	K	Y	S	R	D	K	E	S	E	A	D	D	F	S	F	D	L	L	K	K	R	G	I	S	T	Q	G	L	V	G	S	F	E	T	L	A	S	L	D	G	G	R	T	Q	S	M	F	D	S	H	P	P	S	T
Secondary structure
SS confidence
Disorder						?	?	?	?																																				?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.
Sequence		E	R	A	Q	H	I	R	D	R	I	A	S	G	K
Secondary structure
SS confidence
Disorder												?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3c37 chain B Region: 40 - 254 Aligned: 197 Modelled: 215 Confidence: 100.0% Identity: 26% PDB header:hydrolase Chain: B: PDB Molecule:peptidase, m48 family; PDBTitle: x-ray structure of the putative zn-dependent peptidase q74d82 at the2 resolution 1.7 a. northeast structural genomics consortium target3 gsr143a Phyre2 PDB 3cqb chain B Region: 62 - 143 Aligned: 82 Modelled: 81 Confidence: 99.7% Identity: 26% PDB header:hydrolase Chain: B: PDB Molecule:probable protease htpx homolog; PDBTitle: crystal structure of heat shock protein htpx domain from vibrio2 parahaemolyticus rimd 2210633 Phyre2 PDB 3dtk chain A Region: 72 - 222 Aligned: 119 Modelled: 123 Confidence: 97.4% Identity: 17% PDB header:gene regulation Chain: A: PDB Molecule:irre protein; PDBTitle: crystal structure of the irre protein, a central regulator2 of dna damage repair in deinococcaceae Phyre2 PDB 3b7u chain X Region: 74 - 138 Aligned: 63 Modelled: 65 Confidence: 91.3% Identity: 22% PDB header:hydrolase Chain: X: PDB Molecule:leukotriene a-4 hydrolase; PDBTitle: leukotriene a4 hydrolase complexed with kelatorphan Phyre2 PDB 2ejq chain A domain 1 Region: 104 - 139 Aligned: 36 Modelled: 36 Confidence: 89.3% Identity: 19% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: TTHA0227-like Phyre2 PDB 3cia chain A Region: 74 - 138 Aligned: 63 Modelled: 65 Confidence: 87.3% Identity: 11% PDB header:hydrolase Chain: A: PDB Molecule:cold-active aminopeptidase; PDBTitle: crystal structure of cold-aminopeptidase from colwellia2 psychrerythraea Phyre2 PDB 2gtq chain A Region: 71 - 138 Aligned: 68 Modelled: 68 Confidence: 86.7% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase n; PDBTitle: crystal structure of aminopeptidase n from human pathogen neisseria2 meningitidis Phyre2 PDB 1r55 chain A Region: 124 - 139 Aligned: 16 Modelled: 16 Confidence: 86.7% Identity: 25% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Reprolysin-like Phyre2 PDB 3ebh chain A Region: 71 - 138 Aligned: 68 Modelled: 68 Confidence: 86.2% Identity: 19% PDB header:hydrolase inhibitor Chain: A: PDB Molecule:m1 family aminopeptidase; PDBTitle: structure of the m1 alanylaminopeptidase from malaria complexed with2 bestatin Phyre2 PDB 2xs4 chain A Region: 128 - 141 Aligned: 14 Modelled: 14 Confidence: 86.1% Identity: 36% PDB header:hydrolase Chain: A: PDB Molecule:karilysin protease; PDBTitle: structure of karilysin catalytic mmp domain in complex with2 magnesium Phyre2 PDB 1atl chain A Region: 124 - 141 Aligned: 18 Modelled: 18 Confidence: 84.7% Identity: 28% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Reprolysin-like Phyre2 PDB 3b37 chain A Region: 71 - 138 Aligned: 68 Modelled: 68 Confidence: 84.6% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase n; PDBTitle: crystal structure of e. coli aminopeptidase n in complex with tyrosine Phyre2 PDB 2i47 chain A domain 1 Region: 124 - 141 Aligned: 18 Modelled: 18 Confidence: 84.4% Identity: 39% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: TNF-alpha converting enzyme, TACE, catalytic domain Phyre2 PDB 2i47 chain A Region: 124 - 139 Aligned: 16 Modelled: 16 Confidence: 84.4% Identity: 44% PDB header:hydrolase Chain: A: PDB Molecule:adam 17; PDBTitle: crystal structure of catalytic domain of tace with inhibitor Phyre2 PDB 3k7l chain A Region: 128 - 139 Aligned: 12 Modelled: 12 Confidence: 84.2% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:atragin; PDBTitle: structures of two elapid snake venom metalloproteases with2 distinct activities highlight the disulfide patterns in the3 d domain of adamalysin family proteins Phyre2 PDB 1bqq chain M Region: 128 - 141 Aligned: 14 Modelled: 14 Confidence: 83.8% Identity: 50% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 2dw1 chain B Region: 128 - 139 Aligned: 12 Modelled: 12 Confidence: 83.6% Identity: 33% PDB header:apoptosis, toxin Chain: B: PDB Molecule:catrocollastatin; PDBTitle: crystal structure of vap2 from crotalus atrox venom (form 2-2 crystal) Phyre2 PDB 1bsw chain A Region: 124 - 138 Aligned: 15 Modelled: 15 Confidence: 83.5% Identity: 27% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Reprolysin-like Phyre2 PDB 1rm8 chain A Region: 128 - 141 Aligned: 14 Modelled: 14 Confidence: 83.4% Identity: 43% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 2erp chain A Region: 124 - 141 Aligned: 18 Modelled: 18 Confidence: 83.4% Identity: 22% PDB header:toxin Chain: A: PDB Molecule:vascular apoptosis-inducing protein 1; PDBTitle: crystal structure of vascular apoptosis-inducing protein-1(inhibitor-2 bound form) Phyre2 1 c3c37B_ 2 c3cqbB_ 3 c3dtkA_ 4 c3b7uX_ 5 d2ejqa1 6 c3ciaA_ 7 c2gtqA_ 8 d1r55a_ 9 c3ebhA_ 10 c2xs4A_ 11 d1atla_ 12 c3b37A_ 13 d2i47a1 14 c2i47A_ 15 c3k7lA_ 16 d1bqqm_ 17 c2dw1B_ 18 d1bswa_ 19 d1rm8a_ 20 c2erpA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3c37B_ 100.0 26 PDB header:hydrolase Chain: B: PDB Molecule:peptidase, m48 family; PDBTitle: x-ray structure of the putative zn-dependent peptidase q74d82 at the2 resolution 1.7 a. northeast structural genomics consortium target3 gsr143a 2 c3cqbB_ 99.7 26 PDB header:hydrolase Chain: B: PDB Molecule:probable protease htpx homolog; PDBTitle: crystal structure of heat shock protein htpx domain from vibrio2 parahaemolyticus rimd 2210633 3 c3dtkA_ 97.4 17 PDB header:gene regulation Chain: A: PDB Molecule:irre protein; PDBTitle: crystal structure of the irre protein, a central regulator2 of dna damage repair in deinococcaceae 4 c3b7uX_ 91.3 22 PDB header:hydrolase Chain: X: PDB Molecule:leukotriene a-4 hydrolase; PDBTitle: leukotriene a4 hydrolase complexed with kelatorphan 5 d2ejqa1 89.3 19 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:TTHA0227-like 6 c3ciaA_ 87.3 11 PDB header:hydrolase Chain: A: PDB Molecule:cold-active aminopeptidase; PDBTitle: crystal structure of cold-aminopeptidase from colwellia2 psychrerythraea 7 c2gtqA_ 86.7 13 PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase n; PDBTitle: crystal structure of aminopeptidase n from human pathogen neisseria2 meningitidis 8 d1r55a_ 86.7 25 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 9 c3ebhA_ 86.2 19 PDB header:hydrolase inhibitor Chain: A: PDB Molecule:m1 family aminopeptidase; PDBTitle: structure of the m1 alanylaminopeptidase from malaria complexed with2 bestatin 10 c2xs4A_ 86.1 36 PDB header:hydrolase Chain: A: PDB Molecule:karilysin protease; PDBTitle: structure of karilysin catalytic mmp domain in complex with2 magnesium 11 d1atla_ 84.7 28 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 12 c3b37A_ 84.6 13 PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase n; PDBTitle: crystal structure of e. coli aminopeptidase n in complex with tyrosine 13 d2i47a1 84.4 39 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:TNF-alpha converting enzyme, TACE, catalytic domain 14 c2i47A_ 84.4 44 PDB header:hydrolase Chain: A: PDB Molecule:adam 17; PDBTitle: crystal structure of catalytic domain of tace with inhibitor 15 c3k7lA_ 84.2 33 PDB header:hydrolase Chain: A: PDB Molecule:atragin; PDBTitle: structures of two elapid snake venom metalloproteases with2 distinct activities highlight the disulfide patterns in the3 d domain of adamalysin family proteins 16 d1bqqm_ 83.8 50 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 17 c2dw1B_ 83.6 33 PDB header:apoptosis, toxin Chain: B: PDB Molecule:catrocollastatin; PDBTitle: crystal structure of vap2 from crotalus atrox venom (form 2-2 crystal) 18 d1bswa_ 83.5 27 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 19 d1rm8a_ 83.4 43 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 20 c2erpA_ 83.4 22 PDB header:toxin Chain: A: PDB Molecule:vascular apoptosis-inducing protein 1; PDBTitle: crystal structure of vascular apoptosis-inducing protein-1(inhibitor-2 bound form) 21 d2ovxa1 not modelled 83.3 29 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 22 d1y93a1 not modelled 82.9 29 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 23 d1u4ga_ not modelled 82.8 23 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Thermolysin-like 24 c3sksA_ not modelled 82.8 12 PDB header:hydrolase Chain: A: PDB Molecule:putative oligoendopeptidase f; PDBTitle: crystal structure of a putative oligoendopeptidase f from bacillus2 anthracis str. ames 25 c3nqxA_ not modelled 82.5 22 PDB header:hydrolase Chain: A: PDB Molecule:secreted metalloprotease mcp02; PDBTitle: crystal structure of vibriolysin mcp-02 mature enzyme, a zinc2 metalloprotease from m4 family 26 d1qiba_ not modelled 82.4 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 27 d1cxva_ not modelled 82.3 43 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 28 d1xuca1 not modelled 82.2 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 29 c3k7nA_ not modelled 82.1 31 PDB header:hydrolase Chain: A: PDB Molecule:k-like; PDBTitle: structures of two elapid snake venom metalloproteases with2 distinct activities highlight the disulfide patterns in the3 d domain of adamalysin family proteins 30 c2e3xA_ not modelled 81.9 36 PDB header:hydrolase, blood clotting, toxin Chain: A: PDB Molecule:coagulation factor x-activating enzyme heavy chain; PDBTitle: crystal structure of russell's viper venom metalloproteinase 31 d1hv5a_ not modelled 81.8 43 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 32 d1i76a_ not modelled 81.7 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 33 c3qnfA_ not modelled 81.6 14 PDB header:hydrolase Chain: A: PDB Molecule:endoplasmic reticulum aminopeptidase 1; PDBTitle: crystal structure of the open state of human endoplasmic reticulum2 aminopeptidase 1 erap1 34 d4aiga_ not modelled 81.4 31 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 35 d1hfca_ not modelled 81.3 43 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 36 d1hy7a_ not modelled 81.1 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 37 c3p24C_ not modelled 81.0 58 PDB header:hydrolase Chain: C: PDB Molecule:bft-3; PDBTitle: structure of profragilysin-3 from bacteroides fragilis 38 d1mmqa_ not modelled 81.0 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 39 c2cltB_ not modelled 80.7 36 PDB header:hydrolase Chain: B: PDB Molecule:interstitial collagenase; PDBTitle: crystal structure of the active form (full-length) of human2 fibroblast collagenase. 40 c1yp1A_ not modelled 80.3 38 PDB header:hydrolase Chain: A: PDB Molecule:fii; PDBTitle: crystal structure of a non-hemorrhagic fibrin(ogen)olytic2 metalloproteinase from venom of agkistrodon acutus 41 c2xpyA_ not modelled 80.2 16 PDB header:hydrolase Chain: A: PDB Molecule:leukotriene a-4 hydrolase; PDBTitle: structure of native leukotriene a4 hydrolase from saccharomyces2 cerevisiae 42 d1quaa_ not modelled 79.8 31 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 43 d1hova_ not modelled 79.7 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 44 c3mdjB_ not modelled 79.7 13 PDB header:hydrolase/hydrolase inhibitor Chain: B: PDB Molecule:endoplasmic reticulum aminopeptidase 1; PDBTitle: er aminopeptidase, erap1, bound to the zinc aminopeptidase inhibitor,2 bestatin 45 c2jsdA_ not modelled 79.6 36 PDB header:hydrolase Chain: A: PDB Molecule:matrix metalloproteinase-20; PDBTitle: solution structure of mmp20 complexed with nngh 46 c1slmA_ not modelled 79.4 36 PDB header:hydrolase Chain: A: PDB Molecule:stromelysin-1; PDBTitle: crystal structure of fibroblast stromelysin-1: the c-truncated human2 proenzyme 47 d1q3aa_ not modelled 79.4 43 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 48 d1cgla_ not modelled 78.6 43 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 49 c2v4bB_ not modelled 78.6 55 PDB header:hydrolase Chain: B: PDB Molecule:adamts-1; PDBTitle: crystal structure of human adamts-1 catalytic domain and2 cysteine-rich domain (apo-form) 50 d1kufa_ not modelled 78.5 31 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 51 d1wnia_ not modelled 78.3 38 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 52 c1z5hB_ not modelled 78.0 13 PDB header:hydrolase Chain: B: PDB Molecule:tricorn protease interacting factor f3; PDBTitle: crystal structures of the tricorn interacting factor f32 from thermoplasma acidophilum 53 c3g5cA_ not modelled 78.0 18 PDB header:membrane protein Chain: A: PDB Molecule:adam 22; PDBTitle: structural and biochemical studies on the ectodomain of human adam22 54 d1lmla_ not modelled 77.8 22 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Leishmanolysin 55 c3b8zB_ not modelled 77.6 36 PDB header:hydrolase Chain: B: PDB Molecule:protein adamts-5; PDBTitle: high resolution crystal structure of the catalytic domain2 of adamts-5 (aggrecanase-2) 56 d1nd1a_ not modelled 77.4 45 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 57 d3b7sa3 not modelled 76.8 21 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Leukotriene A4 hydrolase catalytic domain 58 d1eaka2 not modelled 76.7 29 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 59 d1fbla2 not modelled 76.7 43 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 60 d1bqba_ not modelled 76.6 18 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Thermolysin-like 61 d1kjpa_ not modelled 76.5 23 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Thermolysin-like 62 c2xdtA_ not modelled 75.2 13 PDB header:hydrolase Chain: A: PDB Molecule:endoplasmic reticulum aminopeptidase 1; PDBTitle: crystal structure of the soluble domain of human2 endoplasmic reticulum aminopeptidase 1 erap1 63 c2rjqA_ not modelled 75.0 36 PDB header:hydrolase Chain: A: PDB Molecule:adamts-5; PDBTitle: crystal structure of adamts5 with inhibitor bound 64 c2rjpC_ not modelled 75.0 45 PDB header:hydrolase Chain: C: PDB Molecule:adamts-4; PDBTitle: crystal structure of adamts4 with inhibitor bound 65 c3se6A_ not modelled 74.6 15 PDB header:hydrolase Chain: A: PDB Molecule:endoplasmic reticulum aminopeptidase 2; PDBTitle: crystal structure of the human endoplasmic reticulum aminopeptidase 2 66 d1c7ka_ not modelled 74.5 55 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Zinc protease 67 c3ba0A_ not modelled 73.6 29 PDB header:hydrolase Chain: A: PDB Molecule:macrophage metalloelastase; PDBTitle: crystal structure of full-length human mmp-12 68 d3e11a1 not modelled 73.5 19 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:TTHA0227-like 69 d1npca_ not modelled 73.2 22 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Thermolysin-like 70 c1su3A_ not modelled 73.1 43 PDB header:hydrolase Chain: A: PDB Molecule:interstitial collagenase; PDBTitle: x-ray structure of human prommp-1: new insights into2 collagenase action 71 c3nqzB_ not modelled 72.9 50 PDB header:hydrolase Chain: B: PDB Molecule:secreted metalloprotease mcp02; PDBTitle: crystal structure of the autoprocessed vibriolysin mcp-02 with e369a2 mutation 72 c2qr4B_ not modelled 72.3 15 PDB header:hydrolase Chain: B: PDB Molecule:peptidase m3b, oligoendopeptidase f; PDBTitle: crystal structure of oligoendopeptidase-f from enterococcus faecium 73 d2ajfa1 not modelled 72.2 25 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 74 c2h1jA_ not modelled 71.1 55 PDB header:hydrolase Chain: A: PDB Molecule:oligoendopeptidase f; PDBTitle: 3.1 a x-ray structure of putative oligoendopeptidase f: crystals grown2 by microfluidic seeding 75 c2vqxA_ not modelled 69.0 36 PDB header:hydrolase Chain: A: PDB Molecule:metalloproteinase; PDBTitle: precursor of protealysin, metalloproteinase from serratia2 proteamaculans. 76 c3ce2A_ not modelled 68.4 42 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative peptidase; PDBTitle: crystal structure of putative peptidase from chlamydophila abortus 77 c1eakA_ not modelled 67.3 29 PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:72 kda type iv collagenase; PDBTitle: catalytic domain of prommp-2 e404q mutant 78 c2xhqA_ not modelled 65.7 20 PDB header:hydrolase Chain: A: PDB Molecule:archaemetzincin; PDBTitle: crystal structure of archaemetzincin (amza) from archaeoglobus2 fulgidus at 1.45 a resolution 79 c1y791_ not modelled 65.1 45 PDB header:hydrolase Chain: 1: PDB Molecule:peptidyl-dipeptidase dcp; PDBTitle: crystal structure of the e.coli dipeptidyl carboxypeptidase2 dcp in complex with a peptidic inhibitor 80 c2j83B_ not modelled 65.0 36 PDB header:hydrolase Chain: B: PDB Molecule:ulilysin; PDBTitle: ulilysin metalloprotease in complex with batimastat. 81 d1sata2 not modelled 64.8 29 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain 82 d1kapp2 not modelled 64.0 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain 83 d1k7ia2 not modelled 63.2 22 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain 84 d1g9ka2 not modelled 63.2 45 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain 85 d1s4bp_ not modelled 60.8 42 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 86 d1i1ip_ not modelled 57.8 42 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 87 c2c6nA_ not modelled 50.6 36 PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:angiotensin-converting enzyme, somatic isoform; PDBTitle: structure of human somatic angiontensin-i converting enzyme n domain2 with lisinopril 88 c1jiwP_ not modelled 50.1 54 PDB header:hydrolase/hyrolase inhibitor Chain: P: PDB Molecule:alkaline metalloproteinase; PDBTitle: crystal structure of the apr-aprin complex 89 c1l6jA_ not modelled 49.5 36 PDB header:hydrolase Chain: A: PDB Molecule:matrix metalloproteinase-9; PDBTitle: crystal structure of human matrix metalloproteinase mmp92 (gelatinase b). 90 c3b4rB_ not modelled 48.8 50 PDB header:hydrolase Chain: B: PDB Molecule:putative zinc metalloprotease mj0392; PDBTitle: site-2 protease from methanocaldococcus jannaschii 91 c3zukB_ not modelled 48.8 32 PDB header:hydrolase/inhibitor Chain: B: PDB Molecule:endopeptidase, peptidase family m13; PDBTitle: crystal structure of mycobacterium tuberculosis zinc metalloprotease2 zmp1 in complex with inhibitor 92 d1k9xa_ not modelled 48.1 10 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 93 c3lqbA_ not modelled 47.8 38 PDB header:hydrolase Chain: A: PDB Molecule:loc792177 protein; PDBTitle: crystal structure of the hatching enzyme zhe1 from the zebrafish danio2 rerio 94 c3dwbA_ not modelled 45.3 27 PDB header:hydrolase Chain: A: PDB Molecule:endothelin-converting enzyme 1; PDBTitle: structure of human ece-1 complexed with phosphoramidon 95 d1j36a_ not modelled 44.4 45 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 96 c2x3bB_ not modelled 44.2 13 PDB header:hydrolase Chain: B: PDB Molecule:toxic extracellular endopeptidase; PDBTitle: asap1 inactive mutant e294a, an extracellular toxic zinc2 metalloendopeptidase 97 d1asta_ not modelled 43.9 42 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Astacin 98 c3edhA_ not modelled 43.1 54 PDB header:hydrolase Chain: A: PDB Molecule:bone morphogenetic protein 1; PDBTitle: crystal structure of bone morphogenetic protein 1 protease2 domain in complex with partially bound dmso 99 c1gxdA_ not modelled 41.6 29 PDB header:hydrolase Chain: A: PDB Molecule:72 kda type iv collagenase; PDBTitle: prommp-2/timp-2 complex 100 c1om8A_ not modelled 41.2 50 PDB header:hydrolase Chain: A: PDB Molecule:serralysin; PDBTitle: crystal structure of a cold adapted alkaline protease from pseudomonas2 tac ii 18, co-crystallyzed with 10 mm edta 101 c3lq0A_ not modelled 39.0 33 PDB header:hydrolase Chain: A: PDB Molecule:proastacin; PDBTitle: zymogen structure of crayfish astacin metallopeptidase 102 c2l0rA_ not modelled 38.2 40 PDB header:hydrolase,toxin Chain: A: PDB Molecule:lethal factor; PDBTitle: conformational dynamics of the anthrax lethal factor catalytic center 103 d1dmta_ not modelled 33.3 23 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neutral endopeptidase (neprilysin) 104 d1uzea_ not modelled 31.6 45 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 105 d1saza1 not modelled 31.4 17 Fold:Ribonuclease H-like motif Superfamily:Actin-like ATPase domain Family:Acetokinase-like 106 d1j7na2 not modelled 27.7 29 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Anthrax toxin lethal factor, N- and C-terminal domains 107 d2di4a1 not modelled 26.2 33 Fold:FtsH protease domain-like Superfamily:FtsH protease domain-like Family:FtsH protease domain-like 108 c1wgzC_ not modelled 25.2 21 PDB header:hydrolase Chain: C: PDB Molecule:carboxypeptidase 1; PDBTitle: crystal structure of carboxypeptidase 1 from thermus thermophilus 109 d2ce7a1 not modelled 23.6 28 Fold:FtsH protease domain-like Superfamily:FtsH protease domain-like Family:FtsH protease domain-like 110 d1np3a1 not modelled 23.0 29 Fold:6-phosphogluconate dehydrogenase C-terminal domain-like Superfamily:6-phosphogluconate dehydrogenase C-terminal domain-like Family:Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI)

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0