BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (296 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_P71319 5,10-methylenetetrahydrofolate reductase n=247 T... 541 e-152 UniRef50_B7VLL7 Methylenetetrahydrofolate reductase n=16 Tax=Pro... 484 e-135 UniRef50_Q89B13 5,10-methylenetetrahydrofolate reductase n=74 Ta... 362 1e-98 UniRef50_A3H552 Methylenetetrahydrofolate reductase (Fragment) n... 354 2e-96 UniRef50_B2IJ01 Methylenetetrahydrofolate reductase n=5 Tax=Alph... 316 8e-85 UniRef50_Q3SVZ0 Methylenetetrahydrofolate reductase n=69 Tax=Pro... 295 1e-78 UniRef50_Q5FNV4 Methylenetetrahydrofolate reductase n=1 Tax=Gluc... 287 4e-76 UniRef50_D0RN29 Methylenetetrahydrofolate reductase n=1 Tax=alph... 286 8e-76 UniRef50_Q058D8 Methylenetetrahydrofolate reductase n=1 Tax=Buch... 247 3e-64 UniRef50_Q169G2 Methylenetetrahydrofolate reductase n=39 Tax=Rho... 244 4e-63 UniRef50_Q28TL9 Methylenetetrahydrofolate reductase n=3 Tax=Rhod... 241 2e-62 UniRef50_A1WXM6 Methylenetetrahydrofolate reductase n=221 Tax=Ba... 233 9e-60 UniRef50_Q0FF75 Methylenetetrahydrofolate reductase n=1 Tax=Rhod... 232 1e-59 UniRef50_O67422 5,10-methylenetetrahydrofolate reductase n=9 Tax... 231 2e-59 UniRef50_A6UBB8 Methylenetetrahydrofolate reductase n=45 Tax=Rhi... 224 2e-57 UniRef50_D2QYY6 5,10-methylenetetrahydrofolate reductase n=3 Tax... 218 3e-55 UniRef50_C6NUC2 Methylenetetrahydrofolate reductase n=1 Tax=Acid... 212 1e-53 UniRef50_A8PLM8 Methylenetetrahydrofolate reductase n=1 Tax=Rick... 208 2e-52 UniRef50_Q21NJ7 Methylenetetrahydrofolate reductase n=2 Tax=Gamm... 205 1e-51 UniRef50_A6C2T8 Methylenetetrahydrofolate reductase n=1 Tax=Plan... 204 4e-51 UniRef50_B9Z0I7 Methylenetetrahydrofolate reductase n=1 Tax=Luti... 200 5e-50 UniRef50_A5EYC8 Methylenetetrahydrofolate reductase n=2 Tax=Card... 198 2e-49 UniRef50_C1ZF18 Methylenetetrahydrofolate reductase n=1 Tax=Plan... 197 3e-49 UniRef50_A0LTK4 Methylenetetrahydrofolate reductase n=19 Tax=Act... 196 7e-49 UniRef50_B1ZNX1 Methylenetetrahydrofolate reductase n=2 Tax=Opit... 195 2e-48 UniRef50_O54235 5,10-methylenetetrahydrofolate reductase n=40 Ta... 194 4e-48 UniRef50_Q3A3T2 Methylenetetrahydrofolate reductase n=20 Tax=Bac... 191 3e-47 UniRef50_B5JFK7 Methylenetetrahydrofolate reductase n=1 Tax=Verr... 190 6e-47 UniRef50_B9XQY3 Methylenetetrahydrofolate reductase n=2 Tax=Verr... 186 6e-46 UniRef50_Q0AYF5 Methylenetetrahydrofolate reductase n=10 Tax=Bac... 185 1e-45 UniRef50_B6FS52 Methylenetetrahydrofolate reductase n=1 Tax=Clos... 185 2e-45 UniRef50_Q2ILB5 Methylenetetrahydrofolate reductase n=15 Tax=Bac... 181 2e-44 UniRef50_D1Y625 Methylenetetrahydrofolate reductase n=1 Tax=Pyra... 181 2e-44 UniRef50_Q9SE60 Methylenetetrahydrofolate reductase 1 n=8 Tax=Vi... 181 3e-44 UniRef50_C1SKU9 Methylenetetrahydrofolate reductase n=1 Tax=Deni... 179 1e-43 UniRef50_A8MFK9 Methylenetetrahydrofolate reductase n=7 Tax=Clos... 176 8e-43 UniRef50_Q0CXY7 Methylenetetrahydrofolate reductase n=18 Tax=Dik... 175 1e-42 UniRef50_C4XPB4 Methylenetetrahydrofolate reductase n=11 Tax=Del... 174 3e-42 UniRef50_B1L1W9 Methylenetetrahydrofolate reductase n=30 Tax=Bac... 174 3e-42 UniRef50_O80585 Methylenetetrahydrofolate reductase 2 n=14 Tax=E... 174 4e-42 UniRef50_B2UQZ6 Methylenetetrahydrofolate reductase n=3 Tax=Verr... 172 9e-42 UniRef50_Q04NW1 Methylenetetrahydrofolate reductase n=5 Tax=Lept... 172 1e-41 UniRef50_Q30YC4 Methylenetetrahydrofolate reductase n=5 Tax=Desu... 172 1e-41 UniRef50_A0JXH6 Methylenetetrahydrofolate reductase n=6 Tax=Micr... 170 7e-41 UniRef50_B9HG95 Methylenetetrahydrofolate reductase n=6 Tax=rosi... 169 8e-41 UniRef50_Q0AZY6 Methylenetetrahydrofolate reductase n=5 Tax=Clos... 169 8e-41 UniRef50_C0WB69 Methylenetetrahydrofolate reductase n=1 Tax=Acid... 169 1e-40 UniRef50_B3W8E2 Methylenetetrahydrofolate reductase n=15 Tax=Bac... 167 4e-40 UniRef50_D1B7X9 Methylenetetrahydrofolate reductase n=1 Tax=Ther... 167 5e-40 UniRef50_A8ZV44 Methylenetetrahydrofolate reductase n=2 Tax=Desu... 166 8e-40 UniRef50_A1W0I6 Methylenetetrahydrofolate reductase n=14 Tax=Cam... 166 1e-39 UniRef50_UPI0001C36AF7 5,10-methylenetetrahydrofolate reductase ... 164 3e-39 UniRef50_C7N1R9 Methylenetetrahydrofolate reductase n=2 Tax=Cori... 164 3e-39 UniRef50_C8NQ26 Methylenetetrahydrofolate reductase n=20 Tax=Cor... 164 3e-39 UniRef50_C0EZI4 Methylenetetrahydrofolate reductase n=1 Tax=Euba... 163 5e-39 UniRef50_C5RR04 Methylenetetrahydrofolate reductase n=1 Tax=Clos... 163 6e-39 UniRef50_C8W5Z9 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 162 9e-39 UniRef50_C9RM26 Methylenetetrahydrofolate reductase n=23 Tax=Bac... 160 4e-38 UniRef50_C7LW31 Methylenetetrahydrofolate reductase n=2 Tax=Desu... 160 7e-38 UniRef50_A6TTI5 Methylenetetrahydrofolate reductase n=3 Tax=Clos... 158 2e-37 UniRef50_C5BVR3 Methylenetetrahydrofolate reductase n=1 Tax=Beut... 156 7e-37 UniRef50_Q5M088 Methylenetetrahydrofolate reductase n=47 Tax=Fir... 156 7e-37 UniRef50_P53128 Methylenetetrahydrofolate reductase 2 n=42 Tax=A... 156 8e-37 UniRef50_C7NEN8 Methylenetetrahydrofolate reductase n=8 Tax=Fuso... 155 2e-36 UniRef50_P42898 Methylenetetrahydrofolate reductase n=58 Tax=Met... 153 5e-36 UniRef50_A6W769 Methylenetetrahydrofolate reductase n=1 Tax=Kine... 150 6e-35 UniRef50_D1U6W4 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 147 4e-34 UniRef50_Q8KTS2 Methylenetetrahydrofolate reductase n=1 Tax=Cand... 147 6e-34 UniRef50_A4E8J9 Methylenetetrahydrofolate reductase n=1 Tax=Coll... 147 6e-34 UniRef50_B7G287 Methylenetetrahydrofolate reductase n=3 Tax=stra... 145 2e-33 UniRef50_B8BVS6 Methylenetetrahydrofolate reductase n=1 Tax=Thal... 145 2e-33 UniRef50_Q17693 Probable methylenetetrahydrofolate reductase n=5... 144 3e-33 UniRef50_C4ZCX7 Methylenetetrahydrofolate reductase n=2 Tax=Firm... 143 9e-33 UniRef50_B7GRV7 Methylenetetrahydrofolate reductase n=16 Tax=Bif... 143 9e-33 UniRef50_C5L500 Methylenetetrahydrofolate reductase n=2 Tax=Perk... 142 1e-32 UniRef50_D1BTF0 Methylenetetrahydrofolate reductase n=2 Tax=Acti... 140 4e-32 UniRef50_C7QYL7 Methylenetetrahydrofolate reductase n=2 Tax=Acti... 140 4e-32 UniRef50_A9UZU5 Methylenetetrahydrofolate reductase n=1 Tax=Mono... 140 6e-32 UniRef50_C4R2L4 Methylenetetrahydrofolate reductase n=1 Tax=Pich... 140 6e-32 UniRef50_P46151 Methylenetetrahydrofolate reductase 1 n=10 Tax=S... 140 6e-32 UniRef50_C0QAY2 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 140 6e-32 UniRef50_C6PS47 Methylenetetrahydrofolate reductase n=1 Tax=Clos... 139 1e-31 UniRef50_Q5KN82 Methylenetetrahydrofolate reductase n=1 Tax=Filo... 138 2e-31 UniRef50_C2EUU9 Methylenetetrahydrofolate reductase n=2 Tax=Lact... 137 4e-31 UniRef50_D1ZNB9 Methylenetetrahydrofolate reductase n=1 Tax=Sord... 136 7e-31 UniRef50_A8NEV2 Methylenetetrahydrofolate reductase n=2 Tax=Agar... 136 8e-31 UniRef50_B7GB47 Methylenetetrahydrofolate reductase (Fragment) n... 135 1e-30 UniRef50_A8XGR9 Methylenetetrahydrofolate reductase n=1 Tax=Caen... 135 2e-30 UniRef50_C5DIA7 Methylenetetrahydrofolate reductase n=2 Tax=Sacc... 134 3e-30 UniRef50_B9WCV3 Methylenetetrahydrofolate reductase n=10 Tax=Sac... 134 4e-30 UniRef50_B2GHG1 Methylenetetrahydrofolate reductase n=1 Tax=Kocu... 133 6e-30 UniRef50_C9L8P5 Methylenetetrahydrofolate reductase n=1 Tax=Blau... 133 6e-30 UniRef50_C6BZ56 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 133 9e-30 UniRef50_Q2HBA5 Methylenetetrahydrofolate reductase n=2 Tax=Leot... 132 1e-29 UniRef50_D1BI58 Methylenetetrahydrofolate reductase n=2 Tax=Micr... 132 1e-29 UniRef50_C4Y9Q4 Methylenetetrahydrofolate reductase n=1 Tax=Clav... 131 3e-29 UniRef50_C5FI42 Methylenetetrahydrofolate reductase n=1 Tax=Micr... 130 4e-29 UniRef50_C3PE90 Methylenetetrahydrofolate reductase n=8 Tax=Cory... 130 7e-29 UniRef50_B2A780 Methylenetetrahydrofolate reductase n=1 Tax=Natr... 128 2e-28 UniRef50_Q03V90 Methylenetetrahydrofolate reductase n=2 Tax=Leuc... 128 2e-28 UniRef50_D0JBB4 Methylenetetrahydrofolate reductase n=31 Tax=Bac... 128 3e-28 UniRef50_Q4Q0B9 Methylenetetrahydrofolate reductase n=3 Tax=Leis... 127 3e-28 UniRef50_D0YUL0 Methylenetetrahydrofolate reductase n=1 Tax=Mobi... 126 9e-28 UniRef50_C2KSD1 Methylenetetrahydrofolate reductase n=2 Tax=Mobi... 125 1e-27 UniRef50_A2QUJ5 Methylenetetrahydrofolate reductase n=16 Tax=Leo... 125 2e-27 UniRef50_B7AVK8 Methylenetetrahydrofolate reductase n=1 Tax=Bact... 125 2e-27 UniRef50_A6W6I5 Methylenetetrahydrofolate reductase n=1 Tax=Kine... 125 2e-27 UniRef50_C8V780 Methylenetetrahydrofolate reductase n=17 Tax=Leo... 124 3e-27 UniRef50_C4R2Q6 Methylenetetrahydrofolate reductase n=6 Tax=Sacc... 124 5e-27 UniRef50_A9BEZ6 Methylenetetrahydrofolate reductase n=2 Tax=Ther... 122 1e-26 UniRef50_C7M2P8 Methylenetetrahydrofolate reductase n=1 Tax=Acid... 120 8e-26 UniRef50_Q4P1E8 Methylenetetrahydrofolate reductase n=1 Tax=Usti... 119 1e-25 UniRef50_Q6CEM7 Methylenetetrahydrofolate reductase n=1 Tax=Yarr... 117 3e-25 UniRef50_UPI00015B5A5C PREDICTED: hypothetical protein n=1 Tax=N... 117 4e-25 UniRef50_D1PME0 Methylenetetrahydrofolate reductase n=1 Tax=Subd... 116 1e-24 UniRef50_Q2S0T1 Methylenetetrahydrofolate reductase n=4 Tax=cell... 115 2e-24 UniRef50_A8QAM7 Methylenetetrahydrofolate reductase n=1 Tax=Mala... 114 4e-24 UniRef50_B5Y6J3 Methylenetetrahydrofolate reductase n=2 Tax=Bact... 113 1e-23 UniRef50_C0W5C3 Methylenetetrahydrofolate reductase n=1 Tax=Acti... 109 1e-22 UniRef50_O74927 Methylenetetrahydrofolate reductase 2 n=2 Tax=Sc... 108 2e-22 UniRef50_A7TTE9 Methylenetetrahydrofolate reductase n=2 Tax=Sacc... 107 4e-22 UniRef50_A6L1E2 Methylenetetrahydrofolate reductase n=45 Tax=Bac... 105 1e-21 UniRef50_A8F6Y4 Methylenetetrahydrofolate reductase n=2 Tax=Ther... 102 1e-20 UniRef50_A8Q9P3 Methylenetetrahydrofolate reductase n=1 Tax=Mala... 101 3e-20 UniRef50_B0VZI6 Methylenetetrahydrofolate reductase n=2 Tax=Culi... 93 1e-17 UniRef50_D0P2W8 Methylenetetrahydrofolate reductase n=1 Tax=Phyt... 88 4e-16 UniRef50_UPI00019055D0 5,10-methylenetetrahydrofolate reductase ... 86 1e-15 UniRef50_B2K1S3 Methylenetetrahydrofolate reductase n=22 Tax=Yer... 84 8e-15 UniRef50_UPI0001698591 5,10-methylenetetrahydrofolate reductase ... 75 2e-12 UniRef50_Q05FX5 Methylenetetrahydrofolate reductase n=1 Tax=Cand... 75 3e-12 UniRef50_B2Q6I6 Methylenetetrahydrofolate reductase n=1 Tax=Prov... 73 1e-11 UniRef50_Q5TWY6 Methylenetetrahydrofolate reductase n=1 Tax=Anop... 66 2e-09 UniRef50_A7S5W8 Methylenetetrahydrofolate reductase n=1 Tax=Nema... 65 2e-09 UniRef50_B4LC84 Methylenetetrahydrofolate reductase n=3 Tax=Dros... 65 3e-09 UniRef50_D0RM84 Methylenetetrahydrofolate reductase n=1 Tax=Phyt... 65 3e-09 UniRef50_A4J5C2 Methylenetetrahydrofolate reductase n=5 Tax=Clos... 64 7e-09 UniRef50_A4TRX0 Methylenetetrahydrofolate reductase n=1 Tax=Yers... 64 9e-09 UniRef50_Q67LF9 Methylenetetrahydrofolate reductase n=1 Tax=Symb... 64 9e-09 UniRef50_Q9VTI0 Methylenetetrahydrofolate reductase n=6 Tax=mela... 63 2e-08 UniRef50_D1CBD0 Methylenetetrahydrofolate reductase n=1 Tax=Ther... 62 3e-08 UniRef50_UPI000190699E 5,10-methylenetetrahydrofolate reductase ... 60 7e-08 UniRef50_B0TCJ7 Methylenetetrahydrofolate reductase n=6 Tax=Bact... 59 2e-07 UniRef50_B0K6M8 Methylenetetrahydrofolate reductase n=14 Tax=Clo... 57 7e-07 UniRef50_Q2LZ54 Methylenetetrahydrofolate reductase n=1 Tax=Dros... 57 8e-07 UniRef50_A7VPD0 Methylenetetrahydrofolate reductase n=1 Tax=Clos... 56 2e-06 UniRef50_Q1AXR8 Methylenetetrahydrofolate reductase n=2 Tax=Bact... 56 2e-06 UniRef50_C1F3L2 Methylenetetrahydrofolate reductase n=2 Tax=Bact... 55 2e-06 UniRef50_Q01QP4 Methylenetetrahydrofolate reductase n=2 Tax=Acid... 54 6e-06 UniRef50_A5UUW4 Methylenetetrahydrofolate reductase n=5 Tax=Chlo... 52 2e-05 UniRef50_A8SCX4 Methylenetetrahydrofolate reductase n=3 Tax=Clos... 52 3e-05 UniRef50_B7AQD9 Methylenetetrahydrofolate reductase n=1 Tax=Bact... 52 3e-05 UniRef50_A9B657 Methylenetetrahydrofolate reductase n=1 Tax=Herp... 52 3e-05 UniRef50_B9DIA5 Methylenetetrahydrofolate reductase n=10 Tax=Sta... 51 4e-05 UniRef50_B1GYU6 Methylenetetrahydrofolate reductase n=1 Tax=uncu... 51 4e-05 UniRef50_Q2RJ84 Methylenetetrahydrofolate reductase n=2 Tax=Bact... 50 7e-05 UniRef50_B4MKM9 Methylenetetrahydrofolate reductase n=1 Tax=Dros... 50 1e-04 UniRef50_B7RVE0 Methylenetetrahydrofolate reductase n=1 Tax=mari... 50 1e-04 UniRef50_A5ZMW8 Methylenetetrahydrofolate reductase n=4 Tax=Clos... 50 1e-04 UniRef50_B6A4H7 Methylenetetrahydrofolate reductase n=2 Tax=Rhiz... 49 1e-04 UniRef50_C4GEB4 Methylenetetrahydrofolate reductase n=1 Tax=Shut... 49 2e-04 UniRef50_A4XIN5 Methylenetetrahydrofolate reductase n=1 Tax=Cald... 49 2e-04 UniRef50_B5YJV3 Methylenetetrahydrofolate reductase n=1 Tax=Ther... 49 3e-04 UniRef50_Q189R6 Methylenetetrahydrofolate reductase n=6 Tax=Clos... 47 5e-04 UniRef50_Q12UZ6 Methylenetetrahydrofolate reductase n=4 Tax=Meth... 47 8e-04 UniRef50_B0PF81 Methylenetetrahydrofolate reductase n=1 Tax=Anae... 47 8e-04 UniRef50_Q1NSQ8 Methylenetetrahydrofolate reductase n=3 Tax=Delt... 47 0.001 UniRef50_C7MDX6 Methylenetetrahydrofolate reductase n=1 Tax=Brac... 47 0.001 UniRef50_Q60FX0 Methylenetetrahydrofolate reductase n=1 Tax=Sphi... 47 0.001 UniRef50_B9XKW8 Methylenetetrahydrofolate reductase n=1 Tax=bact... 46 0.001 UniRef50_Q3M8T4 Methylenetetrahydrofolate reductase n=56 Tax=Cya... 46 0.001 UniRef50_Q2LQ11 Methylenetetrahydrofolate reductase n=1 Tax=Synt... 46 0.002 UniRef50_C9KNQ4 Methylenetetrahydrofolate reductase n=1 Tax=Mits... 46 0.002 UniRef50_C4DNM1 Methylenetetrahydrofolate reductase n=1 Tax=Stac... 45 0.002 UniRef50_A8SPV0 Methylenetetrahydrofolate reductase n=2 Tax=Clos... 45 0.003 UniRef50_B8FFJ4 Methylenetetrahydrofolate reductase n=4 Tax=Bact... 45 0.003 UniRef50_B9L045 Methylenetetrahydrofolate reductase n=1 Tax=Ther... 45 0.004 UniRef50_B9MN09 Methylenetetrahydrofolate reductase n=2 Tax=root... 45 0.004 UniRef50_D0LSQ2 Methylenetetrahydrofolate reductase n=1 Tax=Hali... 45 0.004 UniRef50_UPI0001AF0D23 5,10-methylenetetrahydrofolate reductase ... 44 0.005 UniRef50_Q4W2U7 Methylenetetrahydrofolate reductase n=1 Tax=Rhod... 44 0.006 UniRef50_C4Z117 Methylenetetrahydrofolate reductase n=1 Tax=Euba... 44 0.006 UniRef50_Q64DN7 5-10-methylenetetrahydrofolate reductase n=3 Tax... 44 0.009 UniRef50_A6UAD8 Methylenetetrahydrofolate reductase n=11 Tax=Pro... 44 0.009 UniRef50_B9JGE7 Methylenetetrahydrofolate reductase n=3 Tax=Rhiz... 42 0.017 UniRef50_A1AKP7 Methylenetetrahydrofolate reductase n=10 Tax=Des... 42 0.017 UniRef50_D1N227 Methylenetetrahydrofolate reductase n=1 Tax=Vict... 42 0.023 UniRef50_A8ZTK4 Methylenetetrahydrofolate reductase n=24 Tax=Bac... 42 0.024 UniRef50_B9KZH8 Methylenetetrahydrofolate reductase n=2 Tax=Ther... 42 0.025 UniRef50_C6VPC5 Methylenetetrahydrofolate reductase n=3 Tax=Lact... 42 0.033 UniRef50_A9QPD6 Methylenetetrahydrofolate reductase n=1 Tax=Meth... 41 0.039 UniRef50_C8WWX3 Methylenetetrahydrofolate reductase n=2 Tax=Alic... 41 0.051 UniRef50_UPI0001BCEC92 bifunctional homocysteine S-methyltransfe... 41 0.056 UniRef50_C7MZV4 Methylenetetrahydrofolate reductase n=1 Tax=Sacc... 41 0.059 UniRef50_C0QIT4 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 40 0.086 >UniRef50_P71319 5,10-methylenetetrahydrofolate reductase n=247 Tax=Proteobacteria RepID=METF_PECCC Length = 298 Score = 541 bits (1393), Expect = e-152, Method: Compositional matrix adjust. Identities = 252/294 (85%), Positives = 278/294 (94%) Query: 1 MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY 60 MSFFHA+QR+ALNQSLAE+QG+INVSFEFFPPRTS+ME+TLW+SIDRLSSLKPKFVSVTY Sbjct: 1 MSFFHANQREALNQSLAELQGRINVSFEFFPPRTSDMEETLWSSIDRLSSLKPKFVSVTY 60 Query: 61 GANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD 120 GANSGERDRTHSIIK IK+RTGLEAAPHLTCIDA+ ++LR IA+DYW +GIRHIVALRGD Sbjct: 61 GANSGERDRTHSIIKTIKERTGLEAAPHLTCIDASREQLREIAQDYWESGIRHIVALRGD 120 Query: 121 LPPGSGKPEMYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRA 180 LP GKP+MYA+DLV+LLKEV DFDISVAAYPEVHPEAKSAQADL+NLK K+DAGANRA Sbjct: 121 LPQEGGKPDMYAADLVSLLKEVGDFDISVAAYPEVHPEAKSAQADLINLKHKIDAGANRA 180 Query: 181 ITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFD 240 ITQFFFDVESYLRFRDRCV+ GIDVEI+PGILPVSNFKQ +KFA MTNVR+P WM MFD Sbjct: 181 ITQFFFDVESYLRFRDRCVATGIDVEIVPGILPVSNFKQLQKFATMTNVRVPNWMTTMFD 240 Query: 241 GLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRP 294 GLD+D ETRK+VGA+IAMDMVKILSREGVKDFHFYTLNRAE+SYAICHTLGVRP Sbjct: 241 GLDNDPETRKMVGASIAMDMVKILSREGVKDFHFYTLNRAELSYAICHTLGVRP 294 >UniRef50_B7VLL7 Methylenetetrahydrofolate reductase n=16 Tax=Proteobacteria RepID=B7VLL7_VIBSL Length = 337 Score = 484 bits (1245), Expect = e-135, Method: Compositional matrix adjust. Identities = 225/294 (76%), Positives = 258/294 (87%) Query: 1 MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY 60 M + HAS DALNQ++AE+ INVSFEFFPP + +ME+TLWNS+ RL +L+PKFVSVTY Sbjct: 39 MGYTHASHIDALNQNIAELSDNINVSFEFFPPSSEKMEETLWNSVHRLKTLQPKFVSVTY 98 Query: 61 GANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD 120 GANSGERDRTHSIIK IK++TGL AAPHLTCIDA+ +EL IA DYW NGI IVALRGD Sbjct: 99 GANSGERDRTHSIIKEIKNQTGLVAAPHLTCIDASREELIQIADDYWANGIESIVALRGD 158 Query: 121 LPPGSGKPEMYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRA 180 +P G G P+MYASDLV LLK DFDISVAA+PEVHPEAKSAQ+DL+NLKRKVDAGANRA Sbjct: 159 IPAGGGAPDMYASDLVELLKSRHDFDISVAAFPEVHPEAKSAQSDLINLKRKVDAGANRA 218 Query: 181 ITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFD 240 ITQFFFDVESYLRFRDRCV+AG+DVEI+PGILPVSNFKQA +FA M NV++P WMA+ F+ Sbjct: 219 ITQFFFDVESYLRFRDRCVAAGVDVEIVPGILPVSNFKQASRFAAMNNVKVPGWMAKQFE 278 Query: 241 GLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRP 294 GLDDD TR+LVGA+ A+DMV+ LSREGVKDFHFYTLNRAEM+YA+CHTLGVRP Sbjct: 279 GLDDDPTTRQLVGASQAIDMVRTLSREGVKDFHFYTLNRAEMTYALCHTLGVRP 332 >UniRef50_Q89B13 5,10-methylenetetrahydrofolate reductase n=74 Tax=Proteobacteria RepID=METF_BUCBP Length = 295 Score = 362 bits (928), Expect = 1e-98, Method: Compositional matrix adjust. Identities = 159/291 (54%), Positives = 219/291 (75%), Gaps = 1/291 (0%) Query: 1 MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY 60 M + + + LNQ L + ++N+SFEFFPP E+ LW ID+L L PKF SVT+ Sbjct: 1 MKLVYKNYHETLNQHLMNICEKVNISFEFFPPNNILSEKNLWQVIDKLKLLTPKFFSVTH 60 Query: 61 GANSGERDR-THSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRG 119 G NS R T +I+K IK TG+E PHLTCI++T +EL+ IA+ YW++GIRHI+ALRG Sbjct: 61 GTNSKIRATCTSNIVKKIKKYTGIETVPHLTCINSTEEELKVIAKTYWDSGIRHILALRG 120 Query: 120 DLPPGSGKPEMYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANR 179 D+ + KP++YA DL+ LLK +A+F+ISVAAYPEVHPEA +A+ D++NLKRKV+AGA R Sbjct: 121 DIFNTNCKPKIYAVDLIKLLKSIANFEISVAAYPEVHPEAVNAKYDIINLKRKVEAGATR 180 Query: 180 AITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMF 239 AITQFFF+++ +LRFRD CV I ++I+PGI P+SNFKQ KF+ ++NV IP W+ MF Sbjct: 181 AITQFFFNIDCFLRFRDLCVKNNITIDIVPGIFPISNFKQLLKFSSVSNVSIPKWLCCMF 240 Query: 240 DGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 GLD+D T +++G++IA+DMVK+L EG++ FHFYTLN++E+S+AIC L Sbjct: 241 HGLDNDLNTSRIIGSSIAIDMVKVLYSEGIRSFHFYTLNKSEISFAICKIL 291 >UniRef50_A3H552 Methylenetetrahydrofolate reductase (Fragment) n=2 Tax=Vibrio cholerae RepID=A3H552_VIBCH Length = 208 Score = 354 bits (909), Expect = 2e-96, Method: Compositional matrix adjust. Identities = 166/206 (80%), Positives = 186/206 (90%) Query: 89 LTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVADFDIS 148 LTCIDAT DEL IA DYW+NGI++IVALRGD+P G GKPEMYASDLVTLLK DFDIS Sbjct: 1 LTCIDATRDELIQIADDYWHNGIQNIVALRGDIPAGGGKPEMYASDLVTLLKSRHDFDIS 60 Query: 149 VAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEII 208 VAA+PEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV+AGIDVEI+ Sbjct: 61 VAAFPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVAAGIDVEIV 120 Query: 209 PGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREG 268 PGILPVSNFKQA +FA NV++P WM + F+GL+DD TR+LVGA+ A+DMV++L REG Sbjct: 121 PGILPVSNFKQASRFAAQNNVKVPNWMVKQFEGLEDDPVTRQLVGASQAIDMVRVLCREG 180 Query: 269 VKDFHFYTLNRAEMSYAICHTLGVRP 294 VKDFHFYTLNRAEM+YA+CHTLGVRP Sbjct: 181 VKDFHFYTLNRAEMTYALCHTLGVRP 206 >UniRef50_B2IJ01 Methylenetetrahydrofolate reductase n=5 Tax=Alphaproteobacteria RepID=B2IJ01_BEII9 Length = 309 Score = 316 bits (809), Expect = 8e-85, Method: Compositional matrix adjust. Identities = 149/281 (53%), Positives = 200/281 (71%), Gaps = 7/281 (2%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 ++VSFEFFPP+T ME TLW SI+RL+ L+P FVSVTYGA R+RTH+ + I T Sbjct: 24 MSVSFEFFPPKTEAMEATLWESINRLAPLQPSFVSVTYGAGGSTRERTHATVARIVKETP 83 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK-----PEMYA--SDL 135 ++ A HLTC+ A+ E+ +A+ YW G+RHIVALRGD G G P+ YA +DL Sbjct: 84 IKPAAHLTCVAASCAEVDAVAKAYWEAGVRHIVALRGDPLEGIGTAFHPHPQGYAHSTDL 143 Query: 136 VTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFR 195 V L+++ADF+ISV+AYPE HPE+ S ++DL L+ K+DAGA RAITQFFF+ ++YLR+ Sbjct: 144 VAGLRKIADFEISVSAYPEKHPESASIESDLDVLQAKIDAGATRAITQFFFENDTYLRYL 203 Query: 196 DRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGAN 255 D+ + GI + I+PGI+PV NFKQ FA IP W+A+ F+GLDDD +TR+L+ A Sbjct: 204 DKVRARGITIPILPGIVPVQNFKQTANFAKKAGASIPPWLAERFEGLDDDPQTRRLIAAT 263 Query: 256 IAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 +A + V L GV+DFHFYT+NRA++ YAICH LG+RP L Sbjct: 264 VAAEQVLDLVDRGVRDFHFYTMNRADLVYAICHLLGLRPKL 304 >UniRef50_Q3SVZ0 Methylenetetrahydrofolate reductase n=69 Tax=Proteobacteria RepID=Q3SVZ0_NITWN Length = 343 Score = 295 bits (755), Expect = 1e-78, Method: Compositional matrix adjust. Identities = 147/279 (52%), Positives = 186/279 (66%), Gaps = 8/279 (2%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 +SFEFFPP+T EME+ LW +I RL+ L P FVSVTYGA R+RTHS I I T L Sbjct: 58 TISFEFFPPKTEEMERNLWGTITRLAPLDPSFVSVTYGAGGSTRERTHSTIARILSDTRL 117 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK-----PEMY--ASDLV 136 A HLTC+ A E+ I Y + G+RHIVALRGD P G G PE Y ++DLV Sbjct: 118 RPAAHLTCVGAPRGEIDEIVSRYRDIGVRHIVALRGDPPGGIGTAYSTHPEGYRTSADLV 177 Query: 137 TLLKEV-ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFR 195 +K D +ISV+AYPE HPE+ D+ LK KVDAGA RAITQ FFD YLR+ Sbjct: 178 AGIKRRHGDIEISVSAYPEKHPESPDIDTDIDVLKAKVDAGATRAITQVFFDNNLYLRYL 237 Query: 196 DRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGAN 255 DR + GID+ I+PGI+P+ NFKQA+ F +PAW+A+ F+GLD+D ETRKL+ A Sbjct: 238 DRVRARGIDIPIVPGIMPMHNFKQARAFVTKAGTTVPAWLAEKFEGLDEDPETRKLIAAT 297 Query: 256 IAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRP 294 +A V+ L++ GV FHFYT+NRA++ +AICH LG+RP Sbjct: 298 VAAGQVQKLAKRGVDTFHFYTMNRADLVFAICHLLGIRP 336 >UniRef50_Q5FNV4 Methylenetetrahydrofolate reductase n=1 Tax=Gluconobacter oxydans RepID=Q5FNV4_GLUOX Length = 309 Score = 287 bits (734), Expect = 4e-76, Method: Compositional matrix adjust. Identities = 136/276 (49%), Positives = 181/276 (65%), Gaps = 5/276 (1%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 +SFE PPRT MEQ LW + RL+ L P+FVSVTYGA + +T + + +K T L Sbjct: 29 LSFEVVPPRTDAMEQRLWQCMRRLAPLSPRFVSVTYGACGTMQAQTQATVLRLKQETTLV 88 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG-KPE----MYASDLVTLL 139 A HLTCI AT +E+ IAR YW G+RHI+ALRGD P G+ P YA DLV L Sbjct: 89 PAAHLTCIGATREEIDDIARTYWQAGVRHILALRGDAPAGTDYTPHPGGYAYAGDLVAGL 148 Query: 140 KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199 + +ADF+ISVAAYPE HP A + QAD+ NLKRK DAGA+RAITQ+FF+ + LRF DRC+ Sbjct: 149 RRIADFEISVAAYPETHPTAPNPQADIDNLKRKFDAGASRAITQYFFEASTCLRFLDRCL 208 Query: 200 SAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMD 259 +AGI I+PGI+PVSN+ +F+ V +P W+ +F+G + E ++ +A + Sbjct: 209 AAGITAPIVPGIMPVSNYDHIARFSAFCGVTVPVWLTHLFEGTAKNPELCRIAACIVAAE 268 Query: 260 MVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPG 295 V+ L G+ +FHF TLNR +++ AI H LGVRP Sbjct: 269 QVRTLQSHGINEFHFSTLNRPDLTCAIAHLLGVRPA 304 >UniRef50_D0RN29 Methylenetetrahydrofolate reductase n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RN29_9RICK Length = 298 Score = 286 bits (731), Expect = 8e-76, Method: Compositional matrix adjust. Identities = 131/278 (47%), Positives = 195/278 (70%), Gaps = 6/278 (2%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 ++ ++ SFEFFP + +E E W S+ +L S P+F SVT+GA GER +T S +K IK Sbjct: 1 MKEELKFSFEFFPSKNAEDEVAAWKSLKKLESFDPQFYSVTFGAGGGERIKTDSFVKKIK 60 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL-PPGSG---KPEMY--A 132 + + A HLTC+D + DE+ IA +++ GI+ IVALRGD+ PG P+ Y A Sbjct: 61 KESNVPVAGHLTCVDMSKDEINDIAVNWFEKGIKRIVALRGDVRKPGEQYKPHPDGYKNA 120 Query: 133 SDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYL 192 +D+ LK++A+FDISVA YPE+HP++K+ + DL NLKRKVDAGA+R ITQFFFD +L Sbjct: 121 ADMTAGLKKLANFDISVAGYPEIHPDSKNKELDLDNLKRKVDAGADRIITQFFFDENIFL 180 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV 252 +FRD GI ++++PGI+P+ N+K+ K F++ +PAW+ + F+G +D+ + +K++ Sbjct: 181 KFRDDIAKQGIKIQLLPGIMPIQNYKRVKNFSNKCGTSVPAWIEKEFEGSEDNPDVQKMI 240 Query: 253 GANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 G++IA D+VK L +EGV +FHFYTLN+ E+SYA+C L Sbjct: 241 GSSIATDLVKKLQKEGVNEFHFYTLNKYELSYAVCSRL 278 >UniRef50_Q058D8 Methylenetetrahydrofolate reductase n=1 Tax=Buchnera aphidicola str. Cc (Cinara cedri) RepID=Q058D8_BUCCC Length = 293 Score = 247 bits (631), Expect = 3e-64, Method: Compositional matrix adjust. Identities = 115/278 (41%), Positives = 168/278 (60%) Query: 15 SLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSII 74 + ++ +I +SFE FPP +++ L+ SI L+ P+F SVT D+T I+ Sbjct: 15 KIYNLKNKIKISFEVFPPGDIFLQKKLFKSIKILNQFNPEFFSVTNSTKINSFDQTFFIV 74 Query: 75 KGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASD 134 K I++ H T I ++ IA YWN+GI++I+ALRGDLP + +YA D Sbjct: 75 KKIRELIHCTVFAHFTTIGCNELKIEKIAHRYWNHGIKNIIALRGDLPVLYSRKIIYAVD 134 Query: 135 LVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 L+ LL + F I VAAYPE HPE+K+ Q DL NL+ K+D G +AITQFFF+++ +L+F Sbjct: 135 LIKLLNSINKFKIFVAAYPEGHPESKNIQEDLNNLRNKLDLGVKQAITQFFFNIDKFLKF 194 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGA 254 RD C S G++V +IPGILP+ NF+Q KKF++MTNV +P W+ F +D + Sbjct: 195 RDTCFSLGLNVNLIPGILPILNFEQLKKFSNMTNVEVPKWILNTFHRHKNDEKKCISCSV 254 Query: 255 NIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 I +D++ L EG+ FH YTLN+ + IC LG+ Sbjct: 255 YIIIDLIIKLYNEGITHFHLYTLNQPHLISLICQRLGL 292 >UniRef50_Q169G2 Methylenetetrahydrofolate reductase n=39 Tax=Rhodobacterales RepID=Q169G2_ROSDO Length = 289 Score = 244 bits (622), Expect = 4e-63, Method: Compositional matrix adjust. Identities = 128/275 (46%), Positives = 163/275 (59%), Gaps = 7/275 (2%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 VSFE FPPR+ + LW + L+ L P+F SVTYGA RD TH + +GL Sbjct: 5 EVSFEVFPPRSIDASFKLWETAQALAPLAPRFFSVTYGAGGTTRDLTHDAAYTLHKSSGL 64 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG----KPEMYAS--DLVT 137 A HLTC+ A+ E IA+ + GI IVALRGD P GS P+ +A+ +L+ Sbjct: 65 PVAAHLTCVGASKSETLAIAQRFAQAGITDIVALRGDAPEGSNGFTPHPDGFANAVELID 124 Query: 138 LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDR 197 L F + V AYPE HPEA S QA++ LK KVDAGA AITQFFF+ +++LRFRD Sbjct: 125 ALARSGQFTLRVGAYPEKHPEAASQQANIDWLKAKVDAGACEAITQFFFEADTFLRFRDD 184 Query: 198 CVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIA 257 CV AGI V I PGILP++N+ A+KFA IPAW+ Q FD D + L+ + Sbjct: 185 CVRAGISVPITPGILPITNWTNARKFAQRCGTSIPAWLDQAFDAAIRD-DRHDLLSRALC 243 Query: 258 MDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 ++ L EGV HFYTLNR E++ ICH LGV Sbjct: 244 TELCSDLVGEGVDKLHFYTLNRPELTREICHALGV 278 >UniRef50_Q28TL9 Methylenetetrahydrofolate reductase n=3 Tax=Rhodobacteraceae RepID=Q28TL9_JANSC Length = 288 Score = 241 bits (615), Expect = 2e-62, Method: Compositional matrix adjust. Identities = 125/279 (44%), Positives = 161/279 (57%), Gaps = 7/279 (2%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 NVSFEFFPP++ E LW ++ L+ L P FVSVTYGA R TH + I G+ Sbjct: 5 NVSFEFFPPKSLEGSFKLWETLGVLAPLDPTFVSVTYGAGGTTRKLTHEAVTAINANFGV 64 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK----PEMYAS--DLVT 137 A HLTC+DAT E IA Y GI IVALRGD P G+ P+ + S DLV Sbjct: 65 PVAAHLTCVDATRAETLEIADQYAQAGITQIVALRGDPPKGTATFQAHPDGFGSSEDLVA 124 Query: 138 LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDR 197 L + FDI V AYP+ HPEA S QA + LK K+DAGA AITQFFF+ +++ RFRD Sbjct: 125 ALAKTGKFDIRVGAYPDPHPEAASMQACVDYLKAKIDAGATSAITQFFFEADTFFRFRDA 184 Query: 198 CVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIA 257 C +AGI I+PGILP+ ++ +A++FA IP W+ + D L+ I Sbjct: 185 CAAAGITAPILPGILPIEDWSRARRFATACGAVIPTWLDDAYTSAIRDGR-EDLLSTAIC 243 Query: 258 MDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 ++ L GV D HFYTLNR E++ +C LGV P + Sbjct: 244 TELCTDLIEGGVDDLHFYTLNRPELTRDVCAALGVAPNV 282 >UniRef50_A1WXM6 Methylenetetrahydrofolate reductase n=221 Tax=Bacteria RepID=A1WXM6_HALHL Length = 304 Score = 233 bits (593), Expect = 9e-60, Method: Compositional matrix adjust. Identities = 117/273 (42%), Positives = 166/273 (60%), Gaps = 6/273 (2%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEA 85 SFEFFPP+T E + L + +RL L P + SVT+GA +DRT + I+ + +A Sbjct: 12 SFEFFPPKTDEGAENLKGTRERLERLNPAYFSVTFGAGGSTQDRTFETVIDIQRNSTADA 71 Query: 86 APHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG---KPEM-YASDLVTLLKE 141 APHL+CIDA+ D L+ + DY G+++IVALRGD P GSG + E+ YA++LV L++E Sbjct: 72 APHLSCIDASRDRLKQMILDYKEQGVKYIVALRGDRPSGSGSMGQGELSYANELVELIRE 131 Query: 142 VAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199 V F I V AYPE HPEA A D+ N RK AGA+ AITQFF++ + Y RF + C Sbjct: 132 VTGDHFYIEVGAYPEFHPEAPDALTDIENFVRKAKAGADSAITQFFYNADCYYRFVEDCE 191 Query: 200 SAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMD 259 G+D+ I+PGI+P+ NF+Q +FA +P W+AQ + DD ++R G ++ Sbjct: 192 KRGVDIPIVPGIMPLMNFEQQARFAAACKADMPRWLAQRMEAWKDDPQSRMEYGIDVVTR 251 Query: 260 MVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 + + L G HFY LN+A + I H LG+ Sbjct: 252 LCEDLLDNGAPGIHFYALNKAPVVERIWHNLGL 284 >UniRef50_Q0FF75 Methylenetetrahydrofolate reductase n=1 Tax=Rhodobacterales bacterium HTCC2255 RepID=Q0FF75_9RHOB Length = 293 Score = 232 bits (591), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 118/274 (43%), Positives = 165/274 (60%), Gaps = 9/274 (3%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 +SFE FPPR + LW +I+ L L P F+SVTYGA+ R+ T S + I ++ Sbjct: 10 LSFEIFPPRNLKASFKLWRTIEVLEKLNPNFISVTYGADGSTRELTQSAVSVIAKEYNID 69 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASD-------LVT 137 A HLTC+ ++ E+ IA +Y G R IVALRGD P G E + +D L+ Sbjct: 70 VAGHLTCVGSSKKEIMDIALEYGKAGARKIVALRGDSPEDQGS-ENHETDNFSSSVELIA 128 Query: 138 LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDR 197 LK+ +F++ VAAYP VHP A+S ++DL LK K DAGA+ AITQFFFD E +LRFRD+ Sbjct: 129 SLKKNTNFELYVAAYPNVHPNAQSEKSDLDVLKAKFDAGADSAITQFFFDKEDFLRFRDK 188 Query: 198 CVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIA 257 C +AGI IIPGILPV N+ + K FA + P WM++ ++ ++ E L+ + Sbjct: 189 CNAAGIYQNIIPGILPVENWSKTKIFAKRCGMDAPQWMSKAYENCKNN-EEHDLLSQALC 247 Query: 258 MDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 +M L +EGV + HFYTLN +++ +C LG Sbjct: 248 TEMCNELMQEGVNNLHFYTLNDPKLTQKVCEALG 281 >UniRef50_O67422 5,10-methylenetetrahydrofolate reductase n=9 Tax=Bacteria RepID=METF_AQUAE Length = 296 Score = 231 bits (590), Expect = 2e-59, Method: Compositional matrix adjust. Identities = 122/276 (44%), Positives = 172/276 (62%), Gaps = 10/276 (3%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 +G ++SFEFFPP+T E E+ L+ +I +L L P FVSVTYGA RDRT +I++ I + Sbjct: 9 KGVFSISFEFFPPKTEEGERQLFETIRKLEKLNPTFVSVTYGAGGSTRDRTRNIVQKIHE 68 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP-------PGSGKPEMYA 132 T L HLTCI T +EL I +DY N GI +I+ALRGD+P P G + YA Sbjct: 69 ETNLTVMAHLTCIAHTREELIDILQDYKNIGIENILALRGDVPRDKPDWRPPKGACK-YA 127 Query: 133 SDLVTLL-KEVAD-FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES 190 +LV L+ KE D F I VA+YPE HPE+ + + ++ K KV+AGA+ +ITQ FF + Sbjct: 128 KELVELIRKEFGDWFSIGVASYPEGHPESPNLEWEVKYFKEKVEAGADFSITQMFFVNDY 187 Query: 191 YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRK 250 Y RF + C +AGID+ IIPGI+P++NFKQ +KFA + IP + + + ++D E K Sbjct: 188 YYRFVEMCKNAGIDISIIPGIMPITNFKQIRKFASLCGATIPQSLIEKLEKVEDKPEEVK 247 Query: 251 LVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAI 286 +G A++ L GV HFYTLN+++ + I Sbjct: 248 KIGIEFAINQCLDLIEHGVPGLHFYTLNKSDATLKI 283 >UniRef50_A6UBB8 Methylenetetrahydrofolate reductase n=45 Tax=Rhizobiales RepID=A6UBB8_SINMW Length = 313 Score = 224 bits (572), Expect = 2e-57, Method: Compositional matrix adjust. Identities = 115/277 (41%), Positives = 163/277 (58%), Gaps = 8/277 (2%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 I SFE+FPP+ EME L+ ++ LS P FV+VTYGA + R+ + +K + Sbjct: 14 IRFSFEYFPPKNDEMEAQLFQTVTALSVFAPAFVTVTYGAGGSTKARSLTTVKRMIGEMA 73 Query: 83 L-EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK-----PEMY--ASD 134 + A HLTC+ A ++ + ++ G+RH VALRGD G G P Y A+D Sbjct: 74 IGNTAAHLTCVGAPKADVDAVVDEFVACGVRHFVALRGDPQGGIGSVYEPFPGGYENAAD 133 Query: 135 LVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 LV L+ DF+ISV+AYPE HPE+ AD+ LKRKVD GA RA+TQFFFD + + R+ Sbjct: 134 LVKALRARGDFEISVSAYPEKHPESSDVAADIDMLKRKVDKGATRALTQFFFDNDDFERY 193 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGA 254 +R AGI + ++PGILP++N Q +KFA + R+P + L+D E R A Sbjct: 194 LERVRRAGIGIPVVPGILPINNLAQVQKFAGLCGARVPESLISRLGPLNDRPEERFREAA 253 Query: 255 NIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 +IA + + L R GV DFH YT+NR ++ A+C +G Sbjct: 254 HIAAEQIADLVRRGVNDFHLYTMNRPQLVTAVCGLIG 290 >UniRef50_D2QYY6 5,10-methylenetetrahydrofolate reductase n=3 Tax=Planctomycetaceae RepID=D2QYY6_9PLAN Length = 292 Score = 218 bits (554), Expect = 3e-55, Method: Compositional matrix adjust. Identities = 118/281 (41%), Positives = 165/281 (58%), Gaps = 14/281 (4%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 G+ +SFE FPP+T+ E ++ SI L + +P ++ TYGA RD+T I +K + Sbjct: 7 GKRTLSFELFPPKTTAGETAMYQSIGELMAFQPDVITCTYGAGGSTRDKTLEITASVKQQ 66 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM------YASD 134 G++ A HLTC+ +T D+LR RD + G+ +IVALRGD P G +M YASD Sbjct: 67 FGVKVASHLTCVGSTQDQLRDYLRDAISRGVENIVALRGDPPKGETSFQMCEGGLRYASD 126 Query: 135 LVTLLKEVADF---DISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESY 191 LV L+K ADF I+VA YPE H EA S DL NLKRKVDAG + ITQ F+D + Sbjct: 127 LVALIK--ADFPELGIAVAGYPETHQEAISYADDLANLKRKVDAGGDAIITQLFYDNADF 184 Query: 192 LRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPA-WMAQMFDGLDDDAETRK 250 RFRD C + GI V IIPGILPV+N Q ++ + ++P+ ++A++ G DD + Sbjct: 185 FRFRDDCDALGITVPIIPGILPVTNLAQIQRITSLCKAKLPSVFVAKL--GEQDDTAWQF 242 Query: 251 LVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 VG A V+ L GV HFY LN+++ + + +G Sbjct: 243 QVGVEQATVQVQELLHAGVPGIHFYVLNKSQATSEVLRGIG 283 >UniRef50_C6NUC2 Methylenetetrahydrofolate reductase n=1 Tax=Acidithiobacillus caldus ATCC 51756 RepID=C6NUC2_9GAMM Length = 276 Score = 212 bits (540), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 108/269 (40%), Positives = 154/269 (57%), Gaps = 2/269 (0%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEA 85 S EFFPP+ E L +I L +L+P + SVTYGA ++RT + + + T LEA Sbjct: 8 SVEFFPPKNPAGEAKLRETIGALQALRPDYASVTYGAAGSTQERTLATVAMLARDTELEA 67 Query: 86 APHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY--ASDLVTLLKEVA 143 PHLTCI +T +R I Y GIR IVALRGDLPP P + A DL+ ++ Sbjct: 68 VPHLTCIGSTEAGIRAILEHYRELGIRRIVALRGDLPPDREDPGFFHQALDLIAYIRAFG 127 Query: 144 DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGI 203 F I AAYPE HP A A+ADL L+RKV+AGA+ ITQ+F++ ++YL+ RD G+ Sbjct: 128 GFQIYAAAYPEFHPRAVHARADLEYLQRKVEAGASGLITQYFYNPDAYLQLRDDLARRGV 187 Query: 204 DVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKI 263 DV I G++P++N+ Q F+ IP ++ + + DD + + +A ++ Sbjct: 188 DVPITVGVMPMTNYAQIANFSAQCGAEIPQFLRRRMESFADDPGAQAELAIEVASRQCRL 247 Query: 264 LSREGVKDFHFYTLNRAEMSYAICHTLGV 292 L +G HFYTLN+AE + AI LG+ Sbjct: 248 LLDQGAPGLHFYTLNQAEATLAIARNLGL 276 >UniRef50_A8PLM8 Methylenetetrahydrofolate reductase n=1 Tax=Rickettsiella grylli RepID=A8PLM8_9COXI Length = 281 Score = 208 bits (530), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 103/274 (37%), Positives = 165/274 (60%), Gaps = 7/274 (2%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKG-IKDR 80 + N SFE FPP+T + L+ + LS LKP + S+T+GA + ++ +IK +KD Sbjct: 6 KFNFSFEVFPPQTHRGLKNLYATRQELSKLKPNYFSITFGAGGAIQHQSLLVIKQFVKD- 64 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM--YASDLVTL 138 G+ A PH++C++ T L + +Y G++ ++ ++GDLP K YA++L++ Sbjct: 65 -GIAATPHISCVNMTYPRLYDLLMEYQQLGVKQLLVIQGDLPKEVPKLSEFNYANELISA 123 Query: 139 LKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRD 196 ++++ F I VAAYPE HP+A S + D+ N KRK++AGAN AITQFFF+ ++Y RF + Sbjct: 124 IRKITGNYFHIIVAAYPEFHPQAFSPRKDIENFKRKIEAGANSAITQFFFNSDAYFRFIE 183 Query: 197 RCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANI 256 C A I + I+PGI P+ N+++ +F+ IP W+ + L +D ++ + VG Sbjct: 184 ACEKASIHIPIVPGITPIINYQKLIQFSTACGAEIPLWLRKHLAMLSNDPQSLQEVGIEF 243 Query: 257 AMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + + L + GVK+FHFYTLNRA +Y I L Sbjct: 244 VTKLCQHLLQNGVKEFHFYTLNRANPTYRIIENL 277 >UniRef50_Q21NJ7 Methylenetetrahydrofolate reductase n=2 Tax=Gammaproteobacteria RepID=Q21NJ7_SACD2 Length = 297 Score = 205 bits (522), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 108/278 (38%), Positives = 157/278 (56%), Gaps = 5/278 (1%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 Q + +SFEFFPP+T + L L+ + P F SVTYGA RD T I+K +++ Sbjct: 4 QQEFRLSFEFFPPKTDVGREKLITVRKELNDIHPDFFSVTYGAGGSTRDNTKGIVKKMRE 63 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE--MYASDLVT 137 GL APHL+ T + + ++Y + G+ IVALRGD+P G G + +YA++LV Sbjct: 64 E-GLNVAPHLSFGGDTEQTILPLLQEYKDMGVDRIVALRGDMPSGVGGAQQLVYANELVA 122 Query: 138 LLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFR 195 +++ D F + VAAYPE+HPEA S D+ LK K DAGAN AITQ+FF+ ++Y F Sbjct: 123 FIRKHFDDYFHLEVAAYPEIHPEATSYLDDVRYLKGKFDAGANSAITQYFFNPDAYFYFM 182 Query: 196 DRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGAN 255 D+C GID I PGI+P+ N++ +F+D IP WM + + D+ E G + Sbjct: 183 DQCQKEGIDQPIYPGIMPILNYRNLARFSDSCGADIPRWMRKRMESFGDNQEALISFGID 242 Query: 256 IAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 ++ L G HFYT+N+ E + I LG+ Sbjct: 243 WISELCDTLLDAGAPGLHFYTMNQTEPTATIIKNLGLE 280 >UniRef50_A6C2T8 Methylenetetrahydrofolate reductase n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C2T8_9PLAN Length = 297 Score = 204 bits (518), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 106/278 (38%), Positives = 157/278 (56%), Gaps = 7/278 (2%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 G +S E FPPR + L+ +++ L +P FVS TYGA RT + I+++ Sbjct: 10 GTFGLSVEIFPPRNESGDAELFKTLEELVRYQPAFVSCTYGAGGSTSKRTIELCALIQNQ 69 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG------SGKPEMYASD 134 A H TC+++T +EL ++ + GI +I+ALRGD P G + YA++ Sbjct: 70 LHNTATAHFTCVNSTREELVEWLQNAVDAGITNIMALRGDPPAGQETFVPADGGLKYANE 129 Query: 135 LVTLL-KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLR 193 LV+L+ K D I VA YPE HPEA A+ DL NLKRKVDAGA+ TQ FF+ E + + Sbjct: 130 LVSLIRKHFPDMGIGVAGYPECHPEASDAEVDLTNLKRKVDAGADAIYTQLFFNNEHFYQ 189 Query: 194 FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVG 253 FR+RC+ AGID I+PGI+P++ +++ ++ M + PA + + DD E + +G Sbjct: 190 FRERCLKAGIDRPIVPGIMPITEYRRIQRIMSMCSSEFPADLVGQLEAAQDDLEAQFEIG 249 Query: 254 ANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 A+ + L +EGV HFY LNR++ I LG Sbjct: 250 VEYAIRQCEQLIKEGVPGIHFYVLNRSQACKRIFDALG 287 >UniRef50_B9Z0I7 Methylenetetrahydrofolate reductase n=1 Tax=Lutiella nitroferrum 2002 RepID=B9Z0I7_9NEIS Length = 287 Score = 200 bits (508), Expect = 5e-50, Method: Compositional matrix adjust. Identities = 103/274 (37%), Positives = 161/274 (58%), Gaps = 5/274 (1%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 I S E +PP + + + L ++ RL++L P++ SVTYGA R+RT ++ + + G Sbjct: 3 IPFSLELYPPTSPQSARQLERALPRLAALGPEYFSVTYGAGGCTRERTLDLVGQLHE-AG 61 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE--MYASDLVTLLK 140 APHL+ + A E+ + Y G+R + ALRGD P G G YASDLV ++ Sbjct: 62 HTVAPHLSGVGAERAEVAELCAHYRRLGVRRLFALRGDTPSGMGSRGDFAYASDLVRFIR 121 Query: 141 EVA--DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRC 198 E + DF I VAAYPEVHP+AKS ADL L+ K +AGAN A+TQ+FF+ +++L RD C Sbjct: 122 EHSGDDFRIEVAAYPEVHPQAKSPAADLAALRVKQEAGANAAVTQYFFNTDAFLYLRDSC 181 Query: 199 VSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAM 258 +AGI + ++PG+LP++ F+ + A+ + +P W+ + + L DD + G ++ Sbjct: 182 HAAGITLPLVPGVLPLTRFRSTAQRAEARGIEMPRWIYRKMESLADDTAAVRAFGLDVTA 241 Query: 259 DMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 + L EGV HF++LN+ + A+ LG+ Sbjct: 242 RQCERLIAEGVPALHFFSLNQIDAIEALHARLGL 275 >UniRef50_A5EYC8 Methylenetetrahydrofolate reductase n=2 Tax=Cardiobacteriaceae RepID=A5EYC8_DICNV Length = 293 Score = 198 bits (503), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 104/281 (37%), Positives = 159/281 (56%), Gaps = 4/281 (1%) Query: 15 SLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSII 74 ++ E + +S EFFP T E+ L LS L ++ SVTYGA RD+T +++ Sbjct: 9 NMIEKSNSLRLSCEFFPAATKIGEKKLAEVRQALSFLNCEYYSVTYGAGGATRDQTIALV 68 Query: 75 KGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE--MYA 132 K + PH+TC+ + + ++ Y GI+H++ LRGD+P G + M A Sbjct: 69 KTLCREAERAVMPHITCVASHKRAIASLLAQYQKLGIKHLMLLRGDMPSGIYQLGDIMSA 128 Query: 133 SDLVTLL-KEVAD-FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES 190 DLV L+ K+ D I VAAYPE HP+A++ Q DL+N K AGAN A+TQ+FF+ ++ Sbjct: 129 RDLVRLVRKQWGDSVHIVVAAYPETHPQAQTQQIDLINFYEKCAAGANEAVTQYFFNGDA 188 Query: 191 YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRK 250 YLRFRD V G+ + I+PGI+P++N+ + +F+D IP W+ + +D+ + Sbjct: 189 YLRFRDDVVKMGVSIPIVPGIMPITNYVRLARFSDNCGTEIPRWIRTRLESYQEDSASLL 248 Query: 251 LVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 GA++ + + L EGV HFYT+NRA+ I LG Sbjct: 249 DFGADVVSQLCQRLVSEGVPGLHFYTMNRADALIEIAKRLG 289 >UniRef50_C1ZF18 Methylenetetrahydrofolate reductase n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZF18_PLALI Length = 310 Score = 197 bits (502), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 99/282 (35%), Positives = 154/282 (54%), Gaps = 9/282 (3%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 GQ +S E FPP+T+E + L ++ S+ P FVS TYGA R RT + I DR Sbjct: 22 GQFALSIEIFPPKTAEGDAALRQALQEFSTYNPAFVSCTYGAGGSTRSRTLDWCREIIDR 81 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM------YASD 134 G+ H TC+ + DEL W G+R+I+ALRGD+P G + + +A Sbjct: 82 VGVAPTAHFTCVGSNSDELIDWLGQAWQLGVRNIMALRGDVPQGETEFKAVEGGFSHARQ 141 Query: 135 LVTLL-KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLR 193 LV L+ KE + I VA YPE HPEA S + D+ LK K+ G + TQ F+D E++ R Sbjct: 142 LVELIRKEFPEMGIGVAGYPEKHPEAVSLETDIAFLKEKITVGGHAVFTQLFYDNETFYR 201 Query: 194 FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDG--LDDDAETRKL 251 + + C+ GID IIPG++P++ + + K+ +++ ++PA + + + L DD + Sbjct: 202 YWEMCLKQGIDAPIIPGVMPITEYSRVKRIVEISGTKVPAELLEQLEAAHLRDDKAAQLE 261 Query: 252 VGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 +G ++ + L GV HFY LN+A + I +LG++ Sbjct: 262 IGIEYSVQQCQDLIDHGVPGLHFYVLNKAHATSQILQSLGLK 303 >UniRef50_A0LTK4 Methylenetetrahydrofolate reductase n=19 Tax=Actinomycetales RepID=A0LTK4_ACIC1 Length = 331 Score = 196 bits (499), Expect = 7e-49, Method: Compositional matrix adjust. Identities = 109/279 (39%), Positives = 154/279 (55%), Gaps = 9/279 (3%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 +G + SFEFFPP+T++ E+ L+ +I L L+P FVSVTYGA T I + I Sbjct: 22 RGGSSFSFEFFPPKTADGERALFQTIRALEVLRPTFVSVTYGAGGSTAAATVRITERIAT 81 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE--------MY 131 T L HLT ++ + E+R + Y G+R+I+ALRGD PPG+ E Y Sbjct: 82 ETTLTPVGHLTIVNQSVAEIRRVIGQYAAAGVRNILALRGD-PPGNPNGEWIPHPHGFRY 140 Query: 132 ASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESY 191 A +LV LLK V DF + VAA+P HP + + + D K AGA+ AITQ FF VE Y Sbjct: 141 AVELVRLLKMVGDFCVGVAAFPRKHPRSPTLEDDTRYFVEKCRAGADFAITQMFFRVEDY 200 Query: 192 LRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKL 251 LR R+R AG V IIPG++P+++ Q ++FA ++ P +A + D + Sbjct: 201 LRLRERIERAGCTVPIIPGVMPITSIGQIERFALLSGDEFPPELADRILAVADQPAAVRA 260 Query: 252 VGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 +G +A +M + L EG HFYTLNR+ + I L Sbjct: 261 IGIEVATEMCRRLLDEGAPGLHFYTLNRSTATREIYQNL 299 >UniRef50_B1ZNX1 Methylenetetrahydrofolate reductase n=2 Tax=Opitutaceae RepID=B1ZNX1_OPITP Length = 292 Score = 195 bits (495), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 103/261 (39%), Positives = 148/261 (56%), Gaps = 7/261 (2%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEA 85 S EF+PP+ + + L + L + P FVSVTYGA ++RT + ++ G Sbjct: 19 SLEFYPPKDAAGVEALRATAHALRRMLPDFVSVTYGAGGSTQERTAQVSSILRKDCGFTV 78 Query: 86 APHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK--PE----MYASDLVTLL 139 PHLTC+ + EL +A + ++G R+I+ALRGD P GS + P+ YA+DLVTLL Sbjct: 79 MPHLTCVGHSQLELAALADGFHDHGFRNIMALRGDPPKGSAQFTPQPDGLRYAADLVTLL 138 Query: 140 KEV-ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRC 198 K DF + VA YPE HPEA S DL NLKRKVDAGA+ TQ FFD Y RF ++C Sbjct: 139 KSRHTDFCLGVAGYPEKHPEAASLDVDLTNLKRKVDAGADFITTQLFFDNTVYYRFVEKC 198 Query: 199 VSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAM 258 + GI V I+PGI+PV + Q ++F M +P + + ++ + + +G + A+ Sbjct: 199 RAVGITVPIVPGIMPVLSLHQIQRFTAMCGATLPKQLITRLEVAAENTDVVETIGIDWAL 258 Query: 259 DMVKILSREGVKDFHFYTLNR 279 ++ L G +H Y LNR Sbjct: 259 TQIRGLLANGAPGYHLYVLNR 279 >UniRef50_O54235 5,10-methylenetetrahydrofolate reductase n=40 Tax=Bacteria RepID=METF_STRLI Length = 307 Score = 194 bits (492), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 111/302 (36%), Positives = 163/302 (53%), Gaps = 11/302 (3%) Query: 1 MSFFHASQRDALNQSLAEV--QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSV 58 M+ AS R +++ ++ G+ SFEF P+T + E+ LW+++ R+ ++ P FVSV Sbjct: 1 MALGTASTRTDRARTVRDILATGKTTYSFEFSAPKTPKGEKNLWSALRRVEAVAPDFVSV 60 Query: 59 TYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALR 118 TYGA R T + I T L HLT +D + ELR I Y + GIR+++A+R Sbjct: 61 TYGAGGSTRAGTVRETQQIVADTTLTPVAHLTAVDHSVAELRNIIGQYADAGIRNMLAVR 120 Query: 119 GDLPPGS------GKPE--MYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLK 170 GD PPG PE YA++LV L+KE DF + VAA+PE+HP + D+ N Sbjct: 121 GD-PPGDPNADWIAHPEGLTYAAELVRLIKESGDFCVGVAAFPEMHPRSADWDTDVTNFV 179 Query: 171 RKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVR 230 K AGA+ AITQ FF +SYLR RDR +AG +IP ++PV++ K ++ ++N Sbjct: 180 DKCRAGADYAITQMFFQPDSYLRLRDRVAAAGCATPVIPEVMPVTSVKMLERLPKLSNAS 239 Query: 231 IPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 PA + + DD + +G A + L EGV HF TLN + + I L Sbjct: 240 FPAELKERILTAKDDPAAVRSIGIEFATEFCARLLAEGVPGLHFITLNNSTATLEIYENL 299 Query: 291 GV 292 G+ Sbjct: 300 GL 301 >UniRef50_Q3A3T2 Methylenetetrahydrofolate reductase n=20 Tax=Bacteria RepID=Q3A3T2_PELCD Length = 301 Score = 191 bits (485), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 104/288 (36%), Positives = 158/288 (54%), Gaps = 16/288 (5%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + SFEFFPP+T + + L+ +I +L SL P F SVTYGA R+RTH ++ I + + Sbjct: 11 ETTFSFEFFPPKTDKAAERLYETIRQLESLHPHFTSVTYGAGGSTRERTHDLVMRIHESS 70 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG------SGKPEMYASDL 135 L+ PHLTC+ + E+ I + Y GI +I+AL GD PP S +A+DL Sbjct: 71 SLDPIPHLTCVSSPEQEIHQILKRYAEAGISNILALAGDPPPDMPHYDRSQDAFPHAADL 130 Query: 136 VTLLKEVAD---------FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFF 186 V +++ D F I VA +PE HP + ++ LK KVD GA+ TQ FF Sbjct: 131 VRFIRKFNDEGLHPDKRGFGIGVAGFPEGHPTTPNRLLEMDYLKAKVDEGADYICTQLFF 190 Query: 187 DVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADM-TNVRIPAWMAQMFDGLDDD 245 D + FR+RC AGI + II GI+P+++ + K+ A++ R PA + + D DD Sbjct: 191 DNRDFYDFRERCELAGISIPIIAGIMPIASVEGMKRMAELAAGARFPAPLLRAVDRCQDD 250 Query: 246 AETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 E+ + +G + A + + L V+ HFYTLN ++ + I LG++ Sbjct: 251 PESVRRIGIHWATEQCRDLLDNEVRGIHFYTLNNSDATRQIFQCLGLQ 298 >UniRef50_B5JFK7 Methylenetetrahydrofolate reductase n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JFK7_9BACT Length = 296 Score = 190 bits (482), Expect = 6e-47, Method: Compositional matrix adjust. Identities = 102/266 (38%), Positives = 147/266 (55%), Gaps = 7/266 (2%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 +S EFFPP++ E L S + L+ P FVSVTYGA RDR+ + ++D Sbjct: 17 LSVEFFPPKSDEALDELVESAEELAPYSPDFVSVTYGAGGSTRDRSAKACQLLRDEHDFN 76 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM------YASDLVTL 138 PHLTC+ A+ EL + G R+I+ALRGD P S + +ASDLV+ Sbjct: 77 IMPHLTCVGASRGELAETINGLYEAGYRNIMALRGDPPKDSNSFVVAKDGFAHASDLVSF 136 Query: 139 LKEV-ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDR 197 +KE+ D I VA YPE HPEA DL +LK KVDAGA+ TQ FFD RF D+ Sbjct: 137 IKELHPDISIGVAGYPEKHPEATDLATDLRHLKTKVDAGASFITTQLFFDNADLYRFLDQ 196 Query: 198 CVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIA 257 GI+V +IPG++PV + KQ K+ A + +P+ + + D+AE + +G A Sbjct: 197 AADQGIEVPVIPGLMPVLSIKQIKRIASLCGASLPSELETHLNAAGDNAELVRQIGVRWA 256 Query: 258 MDMVKILSREGVKDFHFYTLNRAEMS 283 + ++ L +G+ H Y LNR++++ Sbjct: 257 SEQLQDLVEQGLPGVHLYALNRSDIA 282 >UniRef50_B9XQY3 Methylenetetrahydrofolate reductase n=2 Tax=Verrucomicrobia RepID=B9XQY3_9BACT Length = 303 Score = 186 bits (473), Expect = 6e-46, Method: Compositional matrix adjust. Identities = 102/277 (36%), Positives = 152/277 (54%), Gaps = 9/277 (3%) Query: 25 VSFEFFPPRTSEMEQTLW-NSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 +SFEFFPP+T E ++ L +I L LKP F SVTYGA G RD+T I+ I+ L Sbjct: 25 ISFEFFPPKTDEGDRALLEKTIPALLRLKPDFCSVTYGAGGGTRDKTLMIVDRIQREHQL 84 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM------YASDLVT 137 HLTC++AT ++LR + + G+++I+ALRGD P G+G+ +M Y+ LV Sbjct: 85 PTMLHLTCVNATREQLRDVIEQARSLGVKNILALRGDPPGGNGEFKMTDGGFEYSHQLVA 144 Query: 138 LLKEVADFDISVAAYPEVHPEAKSAQ-ADLLNLKRKVDAGANRAITQFFFDVESYLRFRD 196 LL+E+ F I A +PE H K + D +LK+K+D GA+ +TQ F++ Y FRD Sbjct: 145 LLRELGGFSIGTAGFPEGHIACKEGKHVDWEHLKKKIDCGADFVVTQLFYNNADYFEFRD 204 Query: 197 RCVSA-GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGAN 255 G V I PGILP+ + Q K+ + + ++P+ + + L D+ E G + Sbjct: 205 HLTKKLGASVPIFPGILPILSAGQIKRISALCGAKLPSRLVSCLEKLADNDEAAAAYGID 264 Query: 256 IAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 A + L REG H YTLN+A + + L + Sbjct: 265 YATEQCAELLREGAPGLHMYTLNKAPSTIQVLKNLAL 301 >UniRef50_Q0AYF5 Methylenetetrahydrofolate reductase n=10 Tax=Bacteria RepID=Q0AYF5_SYNWW Length = 287 Score = 185 bits (470), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 103/274 (37%), Positives = 152/274 (55%), Gaps = 6/274 (2%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDR-THSIIKGIKDRTGL 83 +S E FPPR + ++ +++ L L P F+SVTYGA E + T I IK+ G+ Sbjct: 13 LSLEIFPPRRTASIGIIYKTLEELQGLNPDFISVTYGAGGSETNTATLEIASAIKNNYGI 72 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE--MYASDLVTLLKE 141 E+ HL CI+ DE+ + + G+ +I+ALRGD+ P + YASDLV+ +KE Sbjct: 73 ESVAHLPCINLNKDEVLNMLEGFKQAGVENILALRGDVNPARVPKQDFRYASDLVSFIKE 132 Query: 142 VADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSA 201 DF+I A YPE H E+ S D+ +LK KVDAG ++ ITQ FFD + FR+R A Sbjct: 133 NGDFNIIGACYPEGHSESPSLLDDIRHLKIKVDAGTDQLITQLFFDNSYFYSFRERASVA 192 Query: 202 GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMV 261 GI+V I GI+PV N +Q ++ + V++P M + +++ E + G A+D + Sbjct: 193 GINVAIEAGIMPVVNKRQIERMVALCGVKLPKKFVTMMERYENNPEAMRDAGIAYAVDQI 252 Query: 262 KILSREGVKDFHFYTLNR---AEMSYAICHTLGV 292 L +GV H YT+N A+ YA TL V Sbjct: 253 VDLIAQGVDGIHLYTMNNPYIAKKIYAAISTLLV 286 >UniRef50_B6FS52 Methylenetetrahydrofolate reductase n=1 Tax=Clostridium nexile DSM 1787 RepID=B6FS52_9CLOT Length = 288 Score = 185 bits (469), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 95/275 (34%), Positives = 148/275 (53%), Gaps = 4/275 (1%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 + ++N+SFE FPP+T + + + +++LKP F+SVTYGA G T I I++ Sbjct: 9 ENRVNISFEVFPPKTDAGYGKVLEATEEIAALKPSFISVTYGAGGGTSKNTVKIASHIQN 68 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP----EMYASDL 135 G+ + HLTC +T +E+R + GI++I+ALRGD+P P YAS+L Sbjct: 69 DLGVASLAHLTCASSTKEEVRQVIEQLKEQGIQNILALRGDIPKDGAFPIPNHYKYASEL 128 Query: 136 VTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFR 195 + +K DF I A YPE H E++ D+ +LK KVD G + TQ FFD F Sbjct: 129 IADIKSQGDFCIGAACYPEGHVESEHKSEDIAHLKEKVDVGVDFLTTQMFFDNSILYNFL 188 Query: 196 DRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGAN 255 R GI V ++PGI+PV+N KQ + +++ +P + D DD + + G Sbjct: 189 YRIREKGITVPVLPGIMPVTNGKQIARICELSGTILPERFRAIVDRFGDDPKAMQQAGIA 248 Query: 256 IAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 A D + L G+++ H Y++N+ E++ AI L Sbjct: 249 YATDQIIDLIANGIQNIHIYSMNKPEIAAAIMTNL 283 >UniRef50_Q2ILB5 Methylenetetrahydrofolate reductase n=15 Tax=Bacteria RepID=Q2ILB5_ANADE Length = 300 Score = 181 bits (460), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 101/284 (35%), Positives = 157/284 (55%), Gaps = 9/284 (3%) Query: 16 LAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIK 75 A +G+ SFEFFPP+T + + L+ +++ L L P +VSVTYGA R +T ++K Sbjct: 9 FARERGEPIFSFEFFPPKTDDGVRGLFETVEALRPLGPAYVSVTYGAGGSTRAKTIDLVK 68 Query: 76 GIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG----KPE-- 129 +K +EA H+TC+ A+ +E+ + + + GI++++ALRGD P G P+ Sbjct: 69 RLKRDAEVEAMAHVTCVGASREEIAAVLDEVADAGIQNVLALRGDAPRGQSAFVPHPDGF 128 Query: 130 MYASDLVTLLK---EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFF 186 +AS+LV ++ E F + AAYPE H E + DL NLK KV+AG + +TQ FF Sbjct: 129 THASELVAFIRSRPERWRFCVGAAAYPEGHVETRDLAQDLRNLKLKVEAGTDFLVTQLFF 188 Query: 187 DVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDA 246 + Y RF +R +AG++V ++PGI+P +N +Q ++F M IP + + D Sbjct: 189 ENAHYFRFVERARAAGVEVPVVPGIMPFTNVEQVERFTAMCGAAIPPPLRAAMEVRRADP 248 Query: 247 ETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + + +G A L R G HFYTLNR+ + AI L Sbjct: 249 DGARELGVAYATLQCADLLRRGAPGIHFYTLNRSPSTRAIVAAL 292 >UniRef50_D1Y625 Methylenetetrahydrofolate reductase n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y625_9BACT Length = 292 Score = 181 bits (460), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 99/282 (35%), Positives = 155/282 (54%), Gaps = 5/282 (1%) Query: 12 LNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTH 71 +N + EV N SFE FPP+ + +++++++D L+SL+P +SVTYGA RD T Sbjct: 1 MNNAFKEVLP--NFSFEIFPPKRTGSLESIYSTVDALASLRPDLISVTYGAGGSNRDNTI 58 Query: 72 SIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY 131 I I++R L A HLTC+ ++ ++ + + G+R I+ALRGD + + Y Sbjct: 59 EIASTIQNRYLLPAVAHLTCVGSSLEQTDALLAELKERGVRTILALRGDRRADADFEDGY 118 Query: 132 ---ASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDV 188 A++LV +K+ DF + A YPE HPEA S +AD+ +LK KVDAG + ITQ F + Sbjct: 119 FKHAAELVAHIKKNYDFRVLGACYPEKHPEAPSLEADIAHLKEKVDAGVDALITQLFLNN 178 Query: 189 ESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAET 248 + + RFRD AG++V II GI+P++ K M IP + + D +AE Sbjct: 179 DDFYRFRDLAQKAGVNVPIIAGIMPITQASMLDKVVSMCGASIPPAVRRFVDAYGHNAEA 238 Query: 249 RKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + G A + L GV+ H Y++N+A ++ I + Sbjct: 239 VREAGIAYAASQIVDLLASGVEGIHIYSMNKAGVTRQIAQNI 280 >UniRef50_Q9SE60 Methylenetetrahydrofolate reductase 1 n=8 Tax=Viridiplantae RepID=MTHR1_ARATH Length = 592 Score = 181 bits (458), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 103/290 (35%), Positives = 156/290 (53%), Gaps = 17/290 (5%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 QGQ SFEFFPP+T + + L+ +DRL S P F +T+GA D T I +++ Sbjct: 13 QGQTAFSFEFFPPKTEDGVENLFERMDRLVSYGPTFCDITWGAGGSTADLTLEIASRMQN 72 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY------AS 133 +E HLTC + +++ +NGI++++ALRGD P G K A Sbjct: 73 VICVETMMHLTCTNMPIEKIDHALETIRSNGIQNVLALRGDPPHGQDKFVQVEGGFACAL 132 Query: 134 DLVTLLK-EVAD-FDISVAAYPEVHPEA---------KSAQADLLNLKRKVDAGANRAIT 182 DLV ++ + D F I+VA YPE HP+ +S Q+DL LK+KVDAGA+ +T Sbjct: 133 DLVNHIRSKYGDYFGITVAGYPEAHPDVIEADGLATPESYQSDLAYLKKKVDAGADLIVT 192 Query: 183 QFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGL 242 Q F+D + +L+F + C GI+ I+PGI+P+SN+K + A +IPA + + + Sbjct: 193 QLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCKTKIPAELTAALEPI 252 Query: 243 DDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 D+ E K G + A +M K + G+ H YTLN + + I LG+ Sbjct: 253 KDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDKSAIGILMNLGL 302 >UniRef50_C1SKU9 Methylenetetrahydrofolate reductase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SKU9_9BACT Length = 284 Score = 179 bits (454), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 101/263 (38%), Positives = 145/263 (55%), Gaps = 9/263 (3%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 +VSFEFFPP+ E EQ L+ +I +L P+FVSVTYGA ++T K +K+ Sbjct: 12 SVSFEFFPPKKQESEQVLFETIKKLRRYNPEFVSVTYGAGGSTTEKTLEWTKRMKEDHDY 71 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG--KPE---MYASDLVTL 138 H TCI A + + + + + +I+ALRGD+P G+ KP YA+DLV Sbjct: 72 SVMMHFTCIGADAAVIDSATQSLKESRVDNILALRGDIPAGTTEFKPTKDFQYAADLVRY 131 Query: 139 LKEVA--DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRD 196 +++ F I VA YPE HPEA S D+ NLKRKVD GA+ ITQ FFD + + D Sbjct: 132 IRKTTGDHFSIGVAGYPEKHPEAGSMAEDIDNLKRKVDEGADFIITQLFFDNFYFYNYLD 191 Query: 197 RCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANI 256 + AGI++ ++ GI+P+ N QA KF DM IP + + + D + + +G + Sbjct: 192 KVRKAGINIPVVAGIMPLVNLSQAVKFTDMCGASIPKPLLEKME--DKSLKDQFEIGLDY 249 Query: 257 AMDMVKILSREGVKDFHFYTLNR 279 A+ L G + HFYTLN+ Sbjct: 250 AVKQCGGLWESGAEGLHFYTLNK 272 >UniRef50_A8MFK9 Methylenetetrahydrofolate reductase n=7 Tax=Clostridiales RepID=A8MFK9_ALKOO Length = 298 Score = 176 bits (446), Expect = 8e-43, Method: Compositional matrix adjust. Identities = 92/270 (34%), Positives = 157/270 (58%), Gaps = 5/270 (1%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN-SGERDRTHSIIKGIKDRTGLE 84 SFE FPP+ + +++++++ L LKP ++SVTYGA +G +RT I IK++ G+E Sbjct: 15 SFEVFPPKVTSPIGSIYDTLEGLQDLKPDYISVTYGAGGNGNDNRTGEIAAIIKNKYGIE 74 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG-SGKPEMYAS-DLVTLLKEV 142 A HLTCI +T ++ + + ++ + G+ +++ALRGD+P G GK E+ S DL+ L++E Sbjct: 75 ALAHLTCIGSTLEQTKGVLQELRDKGVHNVLALRGDIPEGFEGKGELKNSQDLIRLIRED 134 Query: 143 AD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVS 200 F I+ A YPE H E K+ D+ LK K +AGA+ AITQ FFD + F ++ Sbjct: 135 QGNRFGIAAACYPEGHVEGKNVDQDIEILKLKEEAGADHAITQLFFDNNYFYEFLNKVEE 194 Query: 201 AGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDM 260 GI + I GI+PV+N KQ ++ ++ +P ++ + + + E + G A+D Sbjct: 195 KGIQLPIQAGIMPVTNKKQIERIVALSGANLPVKFKKIMEKYEHNKEALRDAGIAYALDQ 254 Query: 261 VKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + L G + H YT+N ++ ++ ++ Sbjct: 255 IVDLISTGARGIHLYTMNNPYIARSVTESI 284 >UniRef50_Q0CXY7 Methylenetetrahydrofolate reductase n=18 Tax=Dikarya RepID=Q0CXY7_ASPTN Length = 619 Score = 175 bits (444), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 97/299 (32%), Positives = 159/299 (53%), Gaps = 12/299 (4%) Query: 4 FHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN 63 H S++ A N E G+ +SFEFFPP+T++ Q L++ +DR+ +L P F+ +T+GA Sbjct: 1 MHISEKLAQN----EAAGRPGISFEFFPPKTAQGVQNLYDRMDRMHALGPSFIDITWGAG 56 Query: 64 SGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP 123 D T ++ + GLE HLTC D +++ + + G +I+ALRGD P Sbjct: 57 GRLSDLTCEMVNVAQSVYGLETCMHLTCTDMPLEKVDAALQSAYKAGCTNILALRGDPPR 116 Query: 124 GSGKPEM------YASDLVTLLKEV--ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDA 175 K E YA DLV +++ FDI V YPE + + +LK KVDA Sbjct: 117 EKEKWEATDGGFRYAKDLVKYIRDKYGNHFDIGVGGYPEGADDNPDVDLLIDHLKEKVDA 176 Query: 176 GANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWM 235 G++ +TQ F+D ++++ + +C + GI+V IIPGI+P+ + + A+ T +RIP Sbjct: 177 GSSFIVTQMFYDTDNFINWVKKCRAKGINVPIIPGIMPIQTYAAFMRRANWTKIRIPPEW 236 Query: 236 AQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRP 294 + + + +D K +G + DM + L G+ HFYT+N A+ + + L + P Sbjct: 237 LEALEPVKNDDAAVKEIGKGLIADMCRRLLAAGINHLHFYTMNLAQSTQLVLEELNLTP 295 >UniRef50_C4XPB4 Methylenetetrahydrofolate reductase n=11 Tax=Deltaproteobacteria RepID=C4XPB4_DESMR Length = 330 Score = 174 bits (442), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 102/275 (37%), Positives = 145/275 (52%), Gaps = 9/275 (3%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 VS EFFPP+ E + +++L ++P FVSVTYGA T I+ +K GLE Sbjct: 54 VSLEFFPPKEREAWDGFFGVVEKLIPVRPLFVSVTYGAGGSTHAHTLEIVSRLKTAYGLE 113 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK--PE----MYASDLVTL 138 HLTC+ A+ D++R G+ +++ALRGD P G P+ +ASDLV Sbjct: 114 PMAHLTCVGASKDKIRGFLGALAQAGVDNVLALRGDPPKGQETFVPDSEDFQHASDLVAF 173 Query: 139 LK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDR 197 ++ E + + VA YPE HPEA S Q DL +L+ K+ G + A+TQ FFD + Y F R Sbjct: 174 IRAEYPNLCLGVAGYPECHPEAVSPQEDLEHLRHKLALGGSFAVTQLFFDNDRYFDFVAR 233 Query: 198 CVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRI-PAWMAQM-FDGLDDDAETRKLVGAN 255 +AGID ++PG+LPV + K+FA + + PA+MA++ VG Sbjct: 234 ARAAGIDAPMVPGVLPVLSLASIKRFAALCGASLPPAYMAELEAADAAGGNAAVAEVGIA 293 Query: 256 IAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 A + L R G H YTLN+AE +I L Sbjct: 294 YARKQAQDLLRRGAPGVHLYTLNKAEAVLSIVSGL 328 >UniRef50_B1L1W9 Methylenetetrahydrofolate reductase n=30 Tax=Bacteria RepID=B1L1W9_CLOBM Length = 295 Score = 174 bits (441), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 94/267 (35%), Positives = 146/267 (54%), Gaps = 3/267 (1%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERD-RTHSIIKGIKDRTGLE 84 SFE FP + + T++ +++ L L P F+SVTYGA +D +T + +K++ G+E Sbjct: 15 SFEIFPSKVTSSITTIYETLEELKDLTPDFISVTYGAGGSLKDNKTCELSSLVKNKYGIE 74 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG--KPEMYASDLVTLLKEV 142 A HLTCI++T D++ I ++ N I +I+ALRGD+P YA +L+ +K Sbjct: 75 ALAHLTCINSTKDDIDLIIKELKENNIENILALRGDIPKDKDIIGEYNYAFELIEKIKAS 134 Query: 143 ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAG 202 +F IS A YPE H E KS D+ LKRKVDAGA I+Q FFD + F ++ Sbjct: 135 NNFGISGACYPEGHIECKSLDQDIRELKRKVDAGAEHLISQLFFDNNIFYEFLNKTQEKS 194 Query: 203 IDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVK 262 I+V I GI+PV N KQ ++ ++ +P ++ D + D + + G A++ + Sbjct: 195 INVPIQAGIMPVVNKKQIERIVKISGATLPKKFMKILDKYEYDKKAMEDAGIAYAVEQIV 254 Query: 263 ILSREGVKDFHFYTLNRAEMSYAICHT 289 L GVK H YT+N ++ I + Sbjct: 255 DLVSSGVKGIHLYTMNNPYIARKITES 281 >UniRef50_O80585 Methylenetetrahydrofolate reductase 2 n=14 Tax=Eukaryota RepID=MTHR2_ARATH Length = 594 Score = 174 bits (440), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 99/296 (33%), Positives = 160/296 (54%), Gaps = 18/296 (6%) Query: 14 QSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSI 73 QSLA+ +G+ SFEFFPP+T + L+ +DR+ + P F +T+GA D T I Sbjct: 8 QSLAD-EGKTAFSFEFFPPKTEDGVDNLFERMDRMVAYGPTFCDITWGAGGSTADLTLDI 66 Query: 74 IKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY-- 131 +++ +E+ HLTC + +++ +NGI++++ALRGD P G K Sbjct: 67 ASRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQDKFVQVEG 126 Query: 132 ----ASDLVTLLK-EVAD-FDISVAAYPEVHPEA---------KSAQADLLNLKRKVDAG 176 A DLV ++ + D F I+VA YPE HP+ ++ Q+DL LK+K+DAG Sbjct: 127 GFDCALDLVNHIRSKYGDYFGITVAGYPEAHPDVIGENGLASNEAYQSDLEYLKKKIDAG 186 Query: 177 ANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMA 236 A+ +TQ F+D + +L+F + C GI I+PGI+P++N++ + +IP + Sbjct: 187 ADLIVTQLFYDTDIFLKFVNDCRQIGISCPIVPGIMPINNYRGFLRMTGFCKTKIPVEVM 246 Query: 237 QMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 + + D+ E K G ++ +M K + GVK H YTLN + + AI LG+ Sbjct: 247 AALEPIKDNEEAVKAYGIHLGTEMCKKMLAHGVKSLHLYTLNMEKSALAILMNLGM 302 >UniRef50_B2UQZ6 Methylenetetrahydrofolate reductase n=3 Tax=Verrucomicrobia RepID=B2UQZ6_AKKM8 Length = 311 Score = 172 bits (437), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 98/289 (33%), Positives = 151/289 (52%), Gaps = 16/289 (5%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 ++SFEFFPP+ + L+ +I L +P FVSVTYGA R+ T ++ I+ + + Sbjct: 14 SLSFEFFPPKNEQAASALYQTIRELEPYRPSFVSVTYGAGGSTRELTREVVLRIQHESRI 73 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE------MYASDLVT 137 PHLTC+ + +E+ I Y G+R ++ALRGD P G+ +A+DLVT Sbjct: 74 PTVPHLTCVGHSREEVWNILDQYARAGVRAVLALRGDPPRGAKDYNRDADVFRHAADLVT 133 Query: 138 LLKEVAD---------FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDV 188 ++E + F I VA +PE HP + ++ LK KVDAGA+ TQ FFD Sbjct: 134 FIREYNESGRHPDPDGFAIGVAGFPEGHPATPNRLREMDFLKAKVDAGADYICTQLFFDN 193 Query: 189 ESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMT-NVRIPAWMAQMFDGLDDDAE 247 S+L +R+RC+ AGI V I+ GI+PV++ + A+++ PA + + + + Sbjct: 194 HSFLDYRERCLLAGIKVPILAGIMPVTSLSGMNRMAELSGGTCFPARLLKALKRAGSNPD 253 Query: 248 TRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 + VG A L V HFYTLN++ + I LG++ L Sbjct: 254 AIQEVGIQYASSQCAELLDSDVDGIHFYTLNQSRATREIYRNLGLKDSL 302 >UniRef50_Q04NW1 Methylenetetrahydrofolate reductase n=5 Tax=Leptospira RepID=Q04NW1_LEPBJ Length = 290 Score = 172 bits (436), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 93/272 (34%), Positives = 144/272 (52%), Gaps = 7/272 (2%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEA 85 SFEFFPP+T + + L ++ L+ L P FV+VTYGA RD+T I+ I Sbjct: 17 SFEFFPPKTQDGDLKLMGTVKELARLDPDFVTVTYGAGGSTRDKTAQILSEISKNYSFPT 76 Query: 86 APHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY------ASDLVTLL 139 H TC+ A D++ ++ ++GI +++ALRGD P G GK + A++L++ + Sbjct: 77 VSHFTCVGANQDQIFKTLKEIRSSGIVNLMALRGDPPKGEGKFKKTEGGFENATELISFI 136 Query: 140 K-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRC 198 + E DF I YPE HP AKS + D+ NLKRKVDAG + ++Q FF + F + Sbjct: 137 RSEKLDFCIGGGCYPEKHPNAKSLEEDVRNLKRKVDAGTDFLVSQLFFVNSIFENFLNLV 196 Query: 199 VSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAM 258 A I +IPGI+P+++F Q ++F + P+ + + ++ E N ++ Sbjct: 197 RKADIRAPVIPGIMPITSFSQIERFRSIAGCEFPSSLIEDLQEVEHRPEEFYRRSLNFSI 256 Query: 259 DMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + L GV H YTLN++ SY I L Sbjct: 257 KQCRELLAMGVPGIHLYTLNQSHASYDIVREL 288 >UniRef50_Q30YC4 Methylenetetrahydrofolate reductase n=5 Tax=Desulfovibrio RepID=Q30YC4_DESDG Length = 316 Score = 172 bits (435), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 96/274 (35%), Positives = 138/274 (50%), Gaps = 8/274 (2%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEA 85 S E+FPP+ EM + ++ RL +L P F SVTYGA G +D T I + K LE Sbjct: 40 SLEYFPPKNPEMWPKFFANVGRLMALNPVFCSVTYGAGGGTQDNTFEITRRFKQDLDLEP 99 Query: 86 APHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG-----KPEMYASDLVTLLK 140 PHLTC+ AT D++R + G+ +++ALRGD P +G +ASDLV + Sbjct: 100 MPHLTCVGATKDKIRGFVSQLRDIGVDNVLALRGDAPADAGFSWDDGEFRHASDLVEFVN 159 Query: 141 -EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199 E + + VA YP HPE+ S DL K K+DAG++ + Q FDV Y F + Sbjct: 160 AEFPEMCVGVAGYPTAHPESASFAEDLHWTKAKIDAGSDFIVCQLLFDVREYFHFVAQLR 219 Query: 200 SAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLD--DDAETRKLVGANIA 257 + G+ ++PGILP+ + + ++ + IP + D A K +G A Sbjct: 220 AMGVTSPVLPGILPIQSLESVRRILSLCGANIPGRFYLQLEEADAKGGAAAVKELGTKFA 279 Query: 258 MDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 DM++ L GV H YTLN+AE I G Sbjct: 280 ADMIRRLVDGGVPGVHLYTLNQAETCLRIAEMAG 313 >UniRef50_A0JXH6 Methylenetetrahydrofolate reductase n=6 Tax=Micrococcineae RepID=A0JXH6_ARTS2 Length = 323 Score = 170 bits (430), Expect = 7e-41, Method: Compositional matrix adjust. Identities = 99/289 (34%), Positives = 147/289 (50%), Gaps = 18/289 (6%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 + +S+E FPPR+ ++LW +I L + P +VSVTYGA+ RD +I + T Sbjct: 19 VALSYELFPPRSPAAAESLWTTIGELEATDPDYVSVTYGASGSNRDTAVELINRLLLETT 78 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE----MYASDLVTL 138 L HLTC+ TP+EL I + + G+R I+ALRGD P P YA DL+ L Sbjct: 79 LRPLAHLTCVGNTPEELSEIIGELLDVGVRGILALRGDRPKDGAAPVSGSLRYAQDLIEL 138 Query: 139 LKEV----------ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDV 188 ++ V + VAAYP HPE+ + D+ L K +GA+ AITQ FF Sbjct: 139 IRRVEQRRSALLCAGKVAVGVAAYPTRHPESPTEAHDVEVLLAKQRSGADFAITQVFFHT 198 Query: 189 ESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVR-IPAWMAQMFDGLDDDAE 247 E Y R AG+ + IIPG++P+++ ++ + A++T V P MA++ D DAE Sbjct: 199 EQYADLITRARRAGVTIPIIPGVMPLTSVRRLNRLAELTGVEPAPELMARLAAA-DTDAE 257 Query: 248 TRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV-RPG 295 R+L+G +D+ G H YT N + + L + RP Sbjct: 258 -RRLIGVRATVDLANAALDAGAPGIHLYTFNEHACALEVLDKLALPRPA 305 >UniRef50_B9HG95 Methylenetetrahydrofolate reductase n=6 Tax=rosids RepID=B9HG95_POPTR Length = 608 Score = 169 bits (429), Expect = 8e-41, Method: Compositional matrix adjust. Identities = 96/288 (33%), Positives = 153/288 (53%), Gaps = 17/288 (5%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 ++ SFEFFPP+T + L+ +DR+ + P F +T+GA D T I +++ Sbjct: 29 KVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADLTLDIANKMQNII 88 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY------ASDL 135 +E HLTC + +++ +NGI++++ALRGD P G K A DL Sbjct: 89 CVETMMHLTCTNMPVEKIDHALETIKSNGIQNVLALRGDPPHGQDKFVQIQGGFACALDL 148 Query: 136 VTLLK-EVAD-FDISVAAYPEVHPEA---------KSAQADLLNLKRKVDAGANRAITQF 184 V ++ + D F I+VA YPE HP+A + Q DL LK+KVDAGA+ +TQ Sbjct: 149 VKHIRSKYGDYFGITVAGYPEAHPDAIGSDGFATPEDYQKDLAYLKQKVDAGADLIVTQL 208 Query: 185 FFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDD 244 F+D + +L+F + C GI I+PGI+P++N+K + +IPA + + + D Sbjct: 209 FYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCKTKIPAEVTAALEPIKD 268 Query: 245 DAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 + E + G ++ +M K + G+K H YTLN + + AI LG+ Sbjct: 269 NEEAVRAYGIHLGTEMCKKILAHGIKTLHLYTLNMEKSALAILMNLGL 316 >UniRef50_Q0AZY6 Methylenetetrahydrofolate reductase n=5 Tax=Clostridiales RepID=Q0AZY6_SYNWW Length = 295 Score = 169 bits (429), Expect = 8e-41, Method: Compositional matrix adjust. Identities = 94/282 (33%), Positives = 149/282 (52%), Gaps = 13/282 (4%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 +S E FPPR + +++++++ L L P ++SVTYGA R+RT I +K G+E Sbjct: 14 LSLEIFPPRMAYPLESVFDTVQELKRLNPAYISVTYGAGGSNRERTVEIAARVKKEYGIE 73 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM--------YASDLV 136 A HLTCI ++++ I GI +I+ALRGD+P +PE YA +L+ Sbjct: 74 AQAHLTCIGHRQEDIKNILARLNREGICNIMALRGDIP--EDEPEFDFRRQEYHYAFELI 131 Query: 137 TLLKEVA--DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 ++ F I+ AA+PE HPE + D+ +LK KVD G + ITQ FFD + F Sbjct: 132 RDIRAAYGDSFGIAAAAHPEGHPECPRLKDDIFHLKNKVDNGVDFLITQLFFDNRIFFDF 191 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGA 254 +RC + GI+ +IPGI+PV N Q K+ + +PA + ++ D + + + G Sbjct: 192 WERCQAMGINCPVIPGIMPVLNAGQIKRMIYLCGASMPAGLLKLVDKYEKEPVDMEKAGI 251 Query: 255 NIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV-RPG 295 + A +K L V H Y++N+ I + +G+ PG Sbjct: 252 DYASQQIKELLENAVAGVHLYSMNKPRQISEIVYNIGLASPG 293 >UniRef50_C0WB69 Methylenetetrahydrofolate reductase n=1 Tax=Acidaminococcus sp. D21 RepID=C0WB69_9FIRM Length = 288 Score = 169 bits (428), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 92/273 (33%), Positives = 147/273 (53%), Gaps = 5/273 (1%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 ++ +S E FPP+ Q + + ++ ++SVTYGA ++ +I + +R+ Sbjct: 11 KVTISCELFPPKKGTELQNAMDIVHAIAIDGVDYMSVTYGAGGTAVGKSLAIASEV-ERS 69 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK-PEM---YASDLVT 137 G+ A HLTCI A D + + RD GI +++ALRGD P G + PE +ASDLV Sbjct: 70 GVPALAHLTCIGAKKDGIARVLRDMKAGGIDNVLALRGDRPQGMDELPESDFPHASDLVR 129 Query: 138 LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDR 197 +KE DF + A YPE HPE+++ DL N+KRKVDAG + +TQ FFD E + F R Sbjct: 130 FIKETGDFCVGCATYPEGHPESRTLDEDLENMKRKVDAGCDFLVTQMFFDNEMFYNFMYR 189 Query: 198 CVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIA 257 ++ G+ V ++ G++P++N KQ ++ ++ IP+ + + + D E + G Sbjct: 190 LLAKGVRVPVVAGVMPITNAKQVERIFTLSGTPIPSKLRAVVERFGDHPEALRQAGMAYT 249 Query: 258 MDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + L G H YT+N+ E+ I TL Sbjct: 250 TGQIMDLIANGFNHIHVYTMNKPEVIGGIRRTL 282 >UniRef50_B3W8E2 Methylenetetrahydrofolate reductase n=15 Tax=Bacteria RepID=B3W8E2_LACCB Length = 290 Score = 167 bits (423), Expect = 4e-40, Method: Compositional matrix adjust. Identities = 97/261 (37%), Positives = 142/261 (54%), Gaps = 8/261 (3%) Query: 25 VSFEFFPPRTSEMEQTL---WNSIDRLSSLKPKFVSVTYGANSGERDR-THSIIKGIKDR 80 +SFE FPPR + L N++D + P FVSVT+GAN + T + K IKD Sbjct: 13 ISFEVFPPRKNASNIALTPILNTLDAVKEADPDFVSVTFGANGNKPHMGTLEVAKLIKDE 72 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM---YASDLVT 137 +E HL T +++ R + + GI +I+ALRGD+P SG+ YA DL+ Sbjct: 73 FDMEPVAHLPAAQLTREQVDAELRGFQDAGIDNILALRGDIP-KSGRVSNDFPYACDLIE 131 Query: 138 LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDR 197 + +V DF++ A YPE HPE+ +D+ +LK KVD+GA++ I+Q FFD + + RFR+R Sbjct: 132 HIHQVGDFNVVAACYPEKHPESPDVVSDIHHLKEKVDSGASQLISQLFFDNQVFYRFRER 191 Query: 198 CVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIA 257 AGI+V I GI+PV N Q ++ A M V +P M + E + G A Sbjct: 192 AQLAGINVPIEAGIMPVINEHQIERMATMAGVNLPPKFVAMMQHFSGNKEAMRDAGIAYA 251 Query: 258 MDMVKILSREGVKDFHFYTLN 278 +D + L GV H YT++ Sbjct: 252 IDQIVDLLVHGVDGIHIYTMD 272 >UniRef50_D1B7X9 Methylenetetrahydrofolate reductase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B7X9_THEAS Length = 298 Score = 167 bits (422), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 98/279 (35%), Positives = 141/279 (50%), Gaps = 6/279 (2%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 +G+ +SFE FPPR + ++ ++ + L P FVSVTYGA RD T I +K+ Sbjct: 9 RGRPVISFEIFPPRGGVPVEEVYRTLGAIKDLAPDFVSVTYGAGGSTRDATLEIASTVKN 68 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM----YASDL 135 R GLE H T + TP E+ + D G+ +++A+RGD P PE + SDL Sbjct: 69 RFGLEVMAHCTGLCHTPPEVHEMVEDLMYEGVHNLLAMRGDPPRDRHVPEGPSFPHGSDL 128 Query: 136 VTLLKEVA--DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLR 193 + L+ + I+ AAYPE H EA+ + DL LK KVD GA ITQ FFD E + R Sbjct: 129 IGYLRRAFGDEVCIAAAAYPEGHVEARDMEEDLAFLKLKVDMGAELLITQLFFDNEIFYR 188 Query: 194 FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVG 253 F + GI V + GI PV N +Q ++ + V P +M DD + G Sbjct: 189 FLESIGRLGIRVPVCAGIFPVLNARQVERIVSLCGVSFPPKFTRMVARYADDPASLAEAG 248 Query: 254 ANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 A + + L GV H YT+NR + + I + +G+ Sbjct: 249 VAYATEQIVDLLAFGVDGIHIYTMNRPDTTRRIMNNIGL 287 >UniRef50_A8ZV44 Methylenetetrahydrofolate reductase n=2 Tax=Desulfobacteraceae RepID=A8ZV44_DESOH Length = 292 Score = 166 bits (420), Expect = 8e-40, Method: Compositional matrix adjust. Identities = 97/272 (35%), Positives = 141/272 (51%), Gaps = 6/272 (2%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 VSFEFFPPR + + T ID L+ LKP ++SVT+GA +D ++ +K + L Sbjct: 15 VSFEFFPPRDEKAQGTFDAVIDELTPLKPDYLSVTFGAGGSTKDGSYQTVKHLTADANLP 74 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS---GKPE--MYASDLVTLL 139 ++ +PD + + Y GI I +RGD P PE MYASDL+ + Sbjct: 75 VVAYVAGYGLSPDTIVNVLDRYRAIGIETIFVIRGDQPREPDFVSHPESFMYASDLIAFI 134 Query: 140 KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199 E DF + A YPE H +A+S + D+ LK KVD GA +TQ+F+D Y + ++C Sbjct: 135 AEQYDFSLGCAGYPEGHLQAESLEKDIEYLKLKVDNGARYVVTQYFYDNTFYFDYVEKCR 194 Query: 200 SAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKL-VGANIAM 258 +AGI V IIPGI+PV K + + + IPA M L D R + G A+ Sbjct: 195 AAGITVPIIPGIMPVYTLKMTRMLSKVCGSSIPASMETALADLADAPADRVVDFGIEKAV 254 Query: 259 DMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + + L +GV HFYT++R+ + I L Sbjct: 255 EQCRGLLEQGVPGLHFYTMDRSRSTREILTRL 286 >UniRef50_A1W0I6 Methylenetetrahydrofolate reductase n=14 Tax=Campylobacter RepID=A1W0I6_CAMJJ Length = 282 Score = 166 bits (419), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 89/264 (33%), Positives = 143/264 (54%), Gaps = 3/264 (1%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN-SGERDRTHSIIKGIKDRTGLE 84 SFE FPPR E + L +D L L P F+SVT+GA S T + I++ + Sbjct: 5 SFEVFPPRKDENIKNLHAILDDLGQLSPNFISVTFGAGGSINSQNTLEVASLIQEEYQIP 64 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE--MYASDLVTLLKEV 142 + HL CI ++ +++ I + + I+ALRGD+ K + YASDL++ +K+ Sbjct: 65 SIVHLPCIHSSKEKITQILQKCKEKNLNQILALRGDICENLEKSKDFSYASDLISFIKKQ 124 Query: 143 ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAG 202 F+I A YPE H E+K+ D+ LK KV+AG ++ ITQ F+D E + F+ C AG Sbjct: 125 EYFEIYAACYPEKHNESKNFIEDIHYLKTKVNAGTDKLITQLFYDNEDFYTFKQNCALAG 184 Query: 203 IDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVK 262 ID+ I GI+P++N +Q K + + +IP ++ + +++A + G A D + Sbjct: 185 IDIPIYAGIMPITNKRQVLKISQLCGAKIPPKFVKILEKYENNALALEDAGIAYACDQIV 244 Query: 263 ILSREGVKDFHFYTLNRAEMSYAI 286 L GV H YT+N+++ + I Sbjct: 245 DLITSGVDGIHLYTMNKSKAAIKI 268 >UniRef50_UPI0001C36AF7 5,10-methylenetetrahydrofolate reductase n=1 Tax=Clostridium hathewayi DSM 13479 RepID=UPI0001C36AF7 Length = 293 Score = 164 bits (415), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 92/279 (32%), Positives = 145/279 (51%), Gaps = 5/279 (1%) Query: 18 EVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG-ERDRTHSIIKG 76 E + +SFE FPP+ + + ++ L L P ++SVT+GA G R+RT + K Sbjct: 14 ETPSKKTLSFEIFPPKKDSELKNIDKTLSVLCELNPDYISVTFGAGGGANRNRTIELAKR 73 Query: 77 IKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE--MYASD 134 IK +E HLTC+ E+ AR N G+++++ALRGD P + E ++ASD Sbjct: 74 IKQEYHVEPVVHLTCLHYDKAEIDEFARVLTNAGLQNVLALRGDKNPNMREKESFLHASD 133 Query: 135 LVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 L+ +K+ DF A YPE HPE++ ++ +LK KV+AGA ++Q FD ++ RF Sbjct: 134 LIAYMKDKWDFCFLGACYPECHPESEDKVCEIKHLKAKVNAGAEVLLSQLCFDNHAFFRF 193 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGA 254 ++ C A I +IPGI+PV N Q K+ M P ++ + + E G Sbjct: 194 QEACRIADIQAPVIPGIMPVINAAQIKRMITMCGATFPVRFQKIIQAYESNKEALFDAGM 253 Query: 255 NIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 + A+ + L V+ H YT+N ++ IC G+R Sbjct: 254 SYALSQIIDLLVSDVEGIHLYTMNNPLVARRICE--GIR 290 >UniRef50_C7N1R9 Methylenetetrahydrofolate reductase n=2 Tax=Coriobacteriaceae RepID=C7N1R9_SLAHD Length = 286 Score = 164 bits (415), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 103/275 (37%), Positives = 148/275 (53%), Gaps = 9/275 (3%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN-SGERDRTHSIIKGIKD 79 G+I VSFE FPP+ + + L+ L P FVSVTY A +G +RT + K +D Sbjct: 10 GKIPVSFETFPPKGEMPVEEARGLMAGLAPLNPAFVSVTYSAGGAGNSERTVDVAKMGQD 69 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYW---NNGIRHIVALRGDLPPGSGKPEM-YASDL 135 GL HLTC+ AT + ++AR++ GI +++ALRGD PG YA DL Sbjct: 70 EFGLTCMAHLTCMGATKE---SVAREFERMREAGIENVLALRGDKVPGRDADVFHYAKDL 126 Query: 136 VTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFR 195 + L +E A F + AAYPE H + A + +LK K DAGA +TQ FF+ + LRF Sbjct: 127 IPLARE-AGFCVGAAAYPEGHVDCLDFDASIRHLKEKQDAGAEFFVTQLFFENDVALRFL 185 Query: 196 DRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGAN 255 D SAGI V I GI+P + Q + M +P+ + ++ + +DD E+ + G Sbjct: 186 DAARSAGITVPITFGIMPFMSKAQLTRMIFMCGASLPSPIIKLLNHYEDDEESLRQAGIE 245 Query: 256 IAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 A + L REGV H YT+NRA+++ A+ L Sbjct: 246 YACNQFVELGREGVDGLHVYTMNRADIASAVMEAL 280 >UniRef50_C8NQ26 Methylenetetrahydrofolate reductase n=20 Tax=Corynebacterineae RepID=C8NQ26_COREF Length = 326 Score = 164 bits (415), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 105/296 (35%), Positives = 154/296 (52%), Gaps = 23/296 (7%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 V G++ S EF PPR E L+ + + L FVSVTYGA R+RT + + + Sbjct: 22 VPGRVPFSVEFMPPRDDAAENRLYRAAEVFHDLGASFVSVTYGAGGSTRERTARVARRLS 81 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM-------- 130 R L HLT +D T EL+ I R Y G+ +++ALRGD PPG E Sbjct: 82 -RQPLTTLVHLTLVDHTIAELQEILRGYAELGLTNLLALRGD-PPGDPLGEWATSEGGMS 139 Query: 131 YASDLVTLLK---EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFD 187 YA +L+ ++K E + FDI +A++PE H A S + D K+ AGA +ITQ FFD Sbjct: 140 YALELIEMIKNSPEFSHFDIGIASFPEGHYRAGSLENDTRYTLAKLRAGAEYSITQMFFD 199 Query: 188 VESYLRFRDRCVSA----GIDVEIIPGILPVSNFKQAKKFADMTNVRIP-AWMAQMFDGL 242 VE +LR RDR V+A G IIPG++P+++ + ++ +++ +P A ++ Sbjct: 200 VEDFLRLRDRLVAADPIHGAK-PIIPGLMPITSLRSVRRQVELSGSTLPRALEEKLLRAA 258 Query: 243 DDDAETR----KLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRP 294 + D E + VG +M + L EGV D HF TLN + + H LG+ P Sbjct: 259 NGDEEANRNEIRKVGIETTSEMAERLIAEGVPDLHFMTLNFTRATQEVLHNLGMAP 314 >UniRef50_C0EZI4 Methylenetetrahydrofolate reductase n=1 Tax=Eubacterium hallii DSM 3353 RepID=C0EZI4_9FIRM Length = 288 Score = 163 bits (413), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 88/271 (32%), Positives = 145/271 (53%), Gaps = 7/271 (2%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 +++SFE FPP+ E L+ ++D L L P+F+S TYGA +T I I++ G Sbjct: 15 LSLSFEVFPPKKWEDFPGLYETLDELKGLHPEFISCTYGAGGSNSKKTAEIASHIENELG 74 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM------YASDLV 136 + + HLTC T D+L + ++ N GI ++ALRGD P + + + S+++ Sbjct: 75 IRSIAHLTCAALTEDKLLSTIENFKNAGIHSVLALRGDKPFDMSEEDFANRQYKHPSEII 134 Query: 137 TLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRD 196 +LK+ A F ++ A YPE H EA S + DL LK KV+ GA+ I+Q FFD +++ RF D Sbjct: 135 PILKK-AGFRVAAACYPEKHYEAPSMEEDLHWLKHKVEQGADALISQLFFDNDAFYRFMD 193 Query: 197 RCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANI 256 GI V I GI+P+++ K +++ IP ++ + ++ + G Sbjct: 194 AADQKGITVPIHAGIMPITSAKMINTTINLSGASIPKALSDLIATYGENPSDMRKAGIEY 253 Query: 257 AMDMVKILSREGVKDFHFYTLNRAEMSYAIC 287 A + L+ +G+ H YT+N +E + IC Sbjct: 254 AARQINDLAEQGMHYVHIYTMNHSETAKEIC 284 >UniRef50_C5RR04 Methylenetetrahydrofolate reductase n=1 Tax=Clostridium cellulovorans 743B RepID=C5RR04_CLOCL Length = 285 Score = 163 bits (413), Expect = 6e-39, Method: Compositional matrix adjust. Identities = 89/270 (32%), Positives = 142/270 (52%), Gaps = 2/270 (0%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEA 85 S E FPP+ ++ + N++D L+ L FVSVTYGA RD T + K IK LE Sbjct: 14 SVELFPPKKTDSFDNIINTLDNLNGLDIDFVSVTYGAGGSSRDNTVKLSKKIKSEYNLEV 73 Query: 86 APHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM-YASDLVTLLKEVAD 144 HLTCI++ DE+ ++ + N + +I+ALRGD+P + YASDL+ +K + D Sbjct: 74 ITHLTCINSKKDEIASLLDEMKENNLENILALRGDIPSEVIYDDYKYASDLIPEIKSLGD 133 Query: 145 FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGID 204 F + A YPE HPEA S D+ LK+K G + I+Q F D + F++R A ++ Sbjct: 134 FCVGAACYPEKHPEAPSNVYDIKKLKQKTALGCDFLISQLFLDNTMFFNFQERLELADVN 193 Query: 205 VEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKIL 264 +++ GI+PV N Q ++ ++ +P ++ + + + K G A+D + L Sbjct: 194 TKVLAGIMPVINKAQFERIIQLSGCNVPPKFKKILEKYEHNPSALKDAGIAYAIDQIIDL 253 Query: 265 SREGVKDFHFYTLNRAEMSYAICHTL-GVR 293 V H Y +N+ E + I + G+R Sbjct: 254 MCHDVDGIHLYIMNKPENAKRILDNITGLR 283 >UniRef50_C8W5Z9 Methylenetetrahydrofolate reductase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8W5Z9_DESAS Length = 294 Score = 162 bits (411), Expect = 9e-39, Method: Compositional matrix adjust. Identities = 96/278 (34%), Positives = 149/278 (53%), Gaps = 9/278 (3%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 G+ +SFEFFP R + +T +I+ L LKP FVSVT+GA ++ ++ ++K +K Sbjct: 10 GKPTLSFEFFPARNEKAAETFNQTIEDLVELKPDFVSVTFGAGGSTKEGSYELVKKLKKE 69 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG------SGKPEMYASD 134 LE +L DE+ + Y + GI +I+ALRGD P S + YAS+ Sbjct: 70 KELEVVAYLAAFALKKDEINAVLNSYQDLGIENILALRGDPPKDADVTQVSAESFKYASE 129 Query: 135 LVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 L + + F + VA YPE H EA S + D+ LK KVD G + I QFF+D + F Sbjct: 130 LAAFIHQNYSFCLGVAGYPEGHIEAPSLKKDIEYLKHKVDQGVDFIIAQFFYDNVCFFDF 189 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV-- 252 R+RC +GI++ ++PGI+PV + K + A +IP + + L + +T+ LV Sbjct: 190 RERCQKSGINIPVLPGIMPVYSVKMMEMLAGSCGAKIPEKLRKGISEL-PEGDTKALVDF 248 Query: 253 GANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 G A + L +EG + HFYT++++E + I L Sbjct: 249 GIEYATGQCEELLKEGARGLHFYTMDKSESTVGIVKGL 286 >UniRef50_C9RM26 Methylenetetrahydrofolate reductase n=23 Tax=Bacteria RepID=C9RM26_FIBSS Length = 296 Score = 160 bits (406), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 87/274 (31%), Positives = 144/274 (52%), Gaps = 7/274 (2%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 Q ++++SFE FPP+ + + + + ++ L P F+SVTYGA G T I K +K Sbjct: 9 QDKMSLSFEVFPPKKETSFENVKAATEAIAKLNPAFMSVTYGAGGGVSQYTLEIAKNLKY 68 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP---GSGKPEMYASDLV 136 + HLTCI +T + + D GI++++ALRGDL P +G+ + V Sbjct: 69 NFNIPMLAHLTCISSTKETIHQRIEDMKAAGIKNVMALRGDLTPELIANGRGDCDYHHAV 128 Query: 137 TLLKEV----ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYL 192 L++E+ ADF I A YPE HPE+ + D+ +LK KV+AGA+ TQ FD + Sbjct: 129 ELIRELKAADADFCIGAACYPEKHPESPNQAEDIKHLKEKVEAGADFLTTQMVFDNNLFF 188 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV 252 F + AG++ ++PGI+P++N Q ++ ++ +P + D D E K Sbjct: 189 SFLYKLRDAGVNCPVLPGIMPITNANQVERAIKLSGSFMPQHFKSLVDKFGSDPEAMKQA 248 Query: 253 GANIAMDMVKILSREGVKDFHFYTLNRAEMSYAI 286 G A D + L G+ + H Y++N+ +++ I Sbjct: 249 GIIYATDQIIDLYANGITNVHVYSMNKPDVAEGI 282 >UniRef50_C7LW31 Methylenetetrahydrofolate reductase n=2 Tax=Desulfovibrionales RepID=C7LW31_DESBD Length = 295 Score = 160 bits (404), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 101/282 (35%), Positives = 140/282 (49%), Gaps = 11/282 (3%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 +S EFFPP+ ++ + +L +L P F SVTYGA + T I+ +K GLE Sbjct: 14 LSLEFFPPKDRAQWPGFFDVVRQLRALAPLFCSVTYGAGGSTQHNTLEIVTRMKQEYGLE 73 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG--SGKPE----MYASDLVTL 138 HLTC+ A L + G+ +++ALRGD P G S P+ + SDLV+ Sbjct: 74 PLAHLTCVGADRARLGSFLSGLGEAGVDNVLALRGDPPRGETSFTPDSEEFQHGSDLVSF 133 Query: 139 LK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDR 197 ++ E +D I VA YPE HPEA S DL L+ KV +GA+ ITQ FFD + Y F R Sbjct: 134 IRQEFSDLCIGVAGYPEKHPEAPSMADDLERLRHKVASGADFVITQLFFDNDRYFDFVVR 193 Query: 198 CVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDD---DAETRKLVGA 254 +AGI V IIPGILPV N ++ +P + + + ++ R L G Sbjct: 194 ARAAGIGVPIIPGILPVQNLGALQRMLTFCGASVPEGYMRDLEHVHKVYGESGVRGL-GL 252 Query: 255 NIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 A ++ L G H YTLN+A+ I R GL Sbjct: 253 GYAKSQIRNLLDRGAPGVHLYTLNKADTCLDIWKDFSSRDGL 294 >UniRef50_A6TTI5 Methylenetetrahydrofolate reductase n=3 Tax=Clostridiales RepID=A6TTI5_ALKMQ Length = 294 Score = 158 bits (400), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 86/266 (32%), Positives = 140/266 (52%), Gaps = 4/266 (1%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 +SFE FPP+ +++ ++D L+ L P F+SVTYGA ++T I IK++ +E Sbjct: 14 ISFEIFPPKKELPISSIYGALDGLADLNPDFISVTYGAGGTGSNKTIEIASIIKNKYEIE 73 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE----MYASDLVTLLK 140 A HLTCI + + ++ + N + +++ALRGD+P + E Y DL+ LK Sbjct: 74 ALAHLTCITSNKEVIQQNIKALQENNLENVLALRGDVPSDFIRREENQYQYGVDLIKELK 133 Query: 141 EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVS 200 DFDI A YPE H E + DL LK K AGAN ++Q FFD E + F ++ + Sbjct: 134 GYGDFDIGAAVYPEGHIECDDVEKDLQYLKEKEAAGANFLVSQLFFDNEIFYGFLEKLKA 193 Query: 201 AGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDM 260 I+ +++ G++P+ + KQ +K M +PA + ++ + E + G A + Sbjct: 194 YKIESKVLAGVMPILSKKQVEKMIFMCGASLPAKVIRLVSKYEHQPELLRQAGIEYAAEQ 253 Query: 261 VKILSREGVKDFHFYTLNRAEMSYAI 286 V L V H YT+N+ +++ I Sbjct: 254 VADLIANEVDGIHIYTMNQPDIAKGI 279 >UniRef50_C5BVR3 Methylenetetrahydrofolate reductase n=1 Tax=Beutenbergia cavernae DSM 12333 RepID=C5BVR3_BEUC1 Length = 337 Score = 156 bits (395), Expect = 7e-37, Method: Compositional matrix adjust. Identities = 97/299 (32%), Positives = 151/299 (50%), Gaps = 31/299 (10%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 +SFE +PPRT E+ W +++ L P + SVTYGA+ + S+++ I T + Sbjct: 13 TISFELYPPRTPAGEERAWETVEALVGADPDYFSVTYGASGSTATASQSLVRRILTETDV 72 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE--------MYASDL 135 A HLTC+ + + R + + ++G+R +ALRGD P +G P+ A DL Sbjct: 73 PAVAHLTCVGLSREHARDVVGGFLDDGVRDFLALRGD--PPAGNPDWRPAPGGLARACDL 130 Query: 136 VTLLKEVAD--------------FDISVAAYP--EVHPEA--KSAQADLLNLKRKVDAGA 177 V L++++ D I+VAAYP + HP A + DL L K GA Sbjct: 131 VALIRDLEDERFAGNAHADVANRLSIAVAAYPGMQEHPGAEFRVRDCDLEALVAKQRCGA 190 Query: 178 NRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQ 237 + AITQ FFDV +Y D AG+ + ++PG+LP+++ ++ ++ ++ + +PA + Sbjct: 191 DYAITQVFFDVRAYTALVDAARGAGVRIPLVPGVLPLTDPRRIRRLCELNAIPLPAELLA 250 Query: 238 MFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAIC-HTLGVRPG 295 D DD E R +G + +V L G H YT NRAE S A+ H G PG Sbjct: 251 RLDAADD--EERVAIGLTATLALVADLLAAGAPGIHLYTFNRAEASLAVLEHAFGRVPG 307 >UniRef50_Q5M088 Methylenetetrahydrofolate reductase n=47 Tax=Firmicutes RepID=Q5M088_STRT1 Length = 311 Score = 156 bits (395), Expect = 7e-37, Method: Compositional matrix adjust. Identities = 93/275 (33%), Positives = 146/275 (53%), Gaps = 8/275 (2%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE-RDRTHSIIKGIKDRTG 82 ++SFE FPP + + + ++D + P F+SVT N ++ T + I++ Sbjct: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG--KPEMYASDLVTLLK 140 + HL I + +++ R+ G+ I+ALRGD+ PG K YA+DL+ +K Sbjct: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146 Query: 141 -EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199 E +FDI A YPE HP++ + +D+ NLK+KVDAG + +TQ FFD E + F+D+C Sbjct: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206 Query: 200 SAGIDVEIIPGILPVSNFKQAKKFADMT-NVRIPAWMAQMFDGLDDDAETRKLVGANIAM 258 AGIDV I GI+P+ N QA + N+ +P + D + D E+ + G A+ Sbjct: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266 Query: 259 DMVKILSREGVKDFHFYTLNRAEMS---YAICHTL 290 D + L + V H YT+N AE + Y H+L Sbjct: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301 >UniRef50_P53128 Methylenetetrahydrofolate reductase 2 n=42 Tax=Ascomycota RepID=MTHR2_YEAST Length = 600 Score = 156 bits (394), Expect = 8e-37, Method: Compositional matrix adjust. Identities = 94/291 (32%), Positives = 155/291 (53%), Gaps = 15/291 (5%) Query: 18 EVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLK-PKFVSVTYGANSGERDRTHS-IIK 75 + G+ SFE+F P+T++ Q L++ +DR+ P+F+ +T+ A G + ++ Sbjct: 12 QTSGKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGGGRLSHLSTDLVA 71 Query: 76 GIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP-------PGSGKP 128 + GLE HLTC + + + +++G ++I+ALRGD P P G Sbjct: 72 TAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPRDAENWTPVEGGF 131 Query: 129 EMYASDLVTLLK-EVAD-FDISVAAYPEVHPEA--KSAQADLLNLKRKVDAGANRAITQF 184 + YA DL+ +K + D F I VA YPE HPE K + DL LK+K+DAG + ITQ Sbjct: 132 Q-YAKDLIKYIKSKYGDHFAIGVAGYPECHPELPNKDVKLDLEYLKQKIDAGGDFIITQM 190 Query: 185 FFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDD 244 F+DV++++ + + +AG+DV IIPGI+P++ + + A + IP + D + D Sbjct: 191 FYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQWGQISIPQHFSSRLDPIKD 250 Query: 245 DAETRKLVGANIAMDMV-KILSREGVKDFHFYTLNRAEMSYAICHTLGVRP 294 D E + +G N+ ++M K+L V H YT+N + I L + P Sbjct: 251 DDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLMILERLNILP 301 >UniRef50_C7NEN8 Methylenetetrahydrofolate reductase n=8 Tax=Fusobacteriaceae RepID=C7NEN8_LEPBD Length = 291 Score = 155 bits (391), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 91/275 (33%), Positives = 146/275 (53%), Gaps = 10/275 (3%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 +SFE FPP + E+ L N L KP F+SVTYGA + T + IK+ E Sbjct: 14 ISFEIFPPNKNFSEEKLKNVTAELVEYKPDFISVTYGAGGKTKGGTIEMASHIKNNLKTE 73 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYASDLVTL 138 HLTC+ + E+ ++ + I++I+ALRGD+P G + YAS+L++ Sbjct: 74 VLAHLTCVGSKKSEIHDYLQEAKSKNIKNILALRGDVPQGETEEIYDKGDYKYASELISD 133 Query: 139 LK---EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFR 195 L+ E DF I A YPE H E DL +LK KV+AG + +Q FFD + +++F+ Sbjct: 134 LRKNSEFNDFSIGGAFYPETHYENNDL-VDLFHLKNKVEAGTDFLASQMFFDNDVFVKFK 192 Query: 196 DRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGAN 255 ++ I V +I GI+PV+N KQ K+ +++ +P + ++ + D+ E+ K G Sbjct: 193 EQAEKLDIKVPLIAGIMPVTNAKQIKRIIELSKCSVPEKLDKLLEKYGDNPESMKKAGIM 252 Query: 256 IAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 A + + L G+K H YT+N+ E++ I + Sbjct: 253 YASEQIIELLAYGIKGIHIYTMNKPEIAKEIMKNI 287 >UniRef50_P42898 Methylenetetrahydrofolate reductase n=58 Tax=Metazoa RepID=MTHR_HUMAN Length = 656 Score = 153 bits (387), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 100/300 (33%), Positives = 152/300 (50%), Gaps = 15/300 (5%) Query: 5 HASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY--GA 62 H R+ + + L G S EFFPPRT+E L + DR+++ P ++ VT+ Sbjct: 42 HERLREKMRRRLE--SGDKWFSLEFFPPRTAEGAVNLISRFDRMAAGGPLYIDVTWHPAG 99 Query: 63 NSGERDRTHS--IIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD 120 + G T S I + GLE H+TC +E+ G+++I+ALRGD Sbjct: 100 DPGSDKETSSMMIASTAVNYCGLETILHMTCCRQRLEEITGHLHKAKQLGLKNIMALRGD 159 Query: 121 LPPGSGKPEM-----YASDLVTLLK-EVAD-FDISVAAYPEVHPEAKSAQADLLNLKRKV 173 P G E YA DLV ++ E D FDI VA YP+ HPEA S +ADL +LK KV Sbjct: 160 -PIGDQWEEEEGGFNYAVDLVKHIRSEFGDYFDICVAGYPKGHPEAGSFEADLKHLKEKV 218 Query: 174 DAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPA 233 AGA+ ITQ FF+ +++ RF C GI I+PGI P+ + ++ ++ + +P Sbjct: 219 SAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLEVPQ 278 Query: 234 WMAQMFDGLDDDAETRKLVGANIAMDMVKILSREG-VKDFHFYTLNRAEMSYAICHTLGV 292 + + + + D+ + G +A+ + + L G V HFYTLNR + + LG+ Sbjct: 279 EIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLHFYTLNREMATTEVLKRLGM 338 >UniRef50_A6W769 Methylenetetrahydrofolate reductase n=1 Tax=Kineococcus radiotolerans SRS30216 RepID=A6W769_KINRD Length = 298 Score = 150 bits (379), Expect = 6e-35, Method: Compositional matrix adjust. Identities = 96/278 (34%), Positives = 139/278 (50%), Gaps = 7/278 (2%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 Q S EF P E Q W +++RL+ L+P F SVTYGA G R+ T + + RT Sbjct: 17 QRRFSVEFSPAHDEEGAQRQWRAVERLARLRPVFASVTYGAGGGTREGTVELASRLAART 76 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD-----LPPGSGKPE--MYASD 134 L HLT + + +LR + RD G+ ++ALRGD P P+ +A + Sbjct: 77 DLRPVAHLTAVGQSVPQLRGVVRDLLAGGVTDVLALRGDPDGDPRAPWRAHPQGLQHADE 136 Query: 135 LVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 LV L VAA+P HPE++ DL +L K AGA AI Q FDVE +LR Sbjct: 137 LVRLALAEGVRSAGVAAFPLGHPESRDLDEDLRHLLGKFAAGAGFAIAQLTFDVEDFLRL 196 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGA 254 RDR +AG ++PG+LPV++ K + +T+ P+W+ + DD + G Sbjct: 197 RDRLAAAGCTAPLVPGLLPVTSPKVLEVTRRLTDGHEPSWLQRRLAPFLDDRGAFREEGV 256 Query: 255 NIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 +A++ + L EGV H Y+LN A + LG+ Sbjct: 257 RLALEDGRRLLAEGVPLLHLYSLNAAGNVETLVEELGL 294 >UniRef50_D1U6W4 Methylenetetrahydrofolate reductase n=1 Tax=Desulfovibrio aespoeensis Aspo-2 RepID=D1U6W4_9DELT Length = 290 Score = 147 bits (371), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 89/277 (32%), Positives = 134/277 (48%), Gaps = 8/277 (2%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 VS E PPR ++ L +KP F +VT GA T + + + G Sbjct: 15 VSIELLPPRREAELAGFGQAVQALKGMKPLFAAVTCGAGGRGAVGTLETARDLAEDHGFT 74 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS---GKPEMYASDLVTLLKE 141 PHLTC+ P L GIR+++A+RGD P G K +ASDLV +++ Sbjct: 75 VMPHLTCVHVPPAALPGQLDALRTCGIRNVLAVRGDFPAGMEPVSKGFRHASDLVARVRQ 134 Query: 142 VA-DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVS 200 +A D + VAAYP+ HP+++S D+ L+ K+D GA+ A+TQ FFD Y DR + Sbjct: 135 LAPDMAVGVAAYPDGHPDSRSILEDIGFLRFKLDQGASFAVTQLFFDNRRYFDMVDRLAA 194 Query: 201 AGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGL---DDDAETRKLVGANIA 257 G IIP ILP+ + Q K+ ++ + +P + + D DA R+ A A Sbjct: 195 MGCTKPIIPSILPIRSLGQIKRVMELCDAPVPGTLLADIEAAHAKDGDAGVRRYGVAQAA 254 Query: 258 MDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRP 294 + ++L +G H Y NRA+M + G+ P Sbjct: 255 SQLSELLE-QGAPGVHLYPFNRADMCLEVVQRAGLLP 290 >UniRef50_Q8KTS2 Methylenetetrahydrofolate reductase n=1 Tax=Candidatus Tremblaya princeps RepID=Q8KTS2_TREPR Length = 300 Score = 147 bits (370), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 97/279 (34%), Positives = 144/279 (51%), Gaps = 24/279 (8%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK--DRT 81 +SFEFF PR+ L + LS P+FVSVT + G++ +I + RT Sbjct: 25 GLSFEFFAPRSHAGSIRLMCAQQVLSRFVPRFVSVTRSTSLGQQAHIDTIASTLSVFPRT 84 Query: 82 GLEAAPHL---TCIDATPDELRTIARDYWNNGIRHIVALRGD--LPPGS-GKPEMYASDL 135 APH+ C A ELR Y GIRH+V LRGD + PGS G PE L Sbjct: 85 ----APHVLFCQCPRALARELRA----YELLGIRHLVLLRGDNGIAPGSIGAPE-----L 131 Query: 136 VTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLR 193 V++++ F I VAAYP+ HP + + D+ L RKV GAN AITQ F++ ++Y R Sbjct: 132 VSMVRRSYGEAFYIDVAAYPDGHPMSSTIFEDVRALARKVRCGANSAITQCFYNPDAYYR 191 Query: 194 FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVG 253 +D G+ + + PGI+PV + +F + V +PAW+ + + L + + G Sbjct: 192 LQDELQRLGVSLPVTPGIMPVLSHDYMSRFILPSGVDVPAWILKRLEALRYCSASVLEFG 251 Query: 254 ANIAMDMVKILSREGVKDFHFYTLNRAEMSYAIC-HTLG 291 ++A+ + + L+ G DFH YT+N + +C H LG Sbjct: 252 TDVALSLCESLAARGASDFHLYTMNDHRAVWRVCEHVLG 290 >UniRef50_A4E8J9 Methylenetetrahydrofolate reductase n=1 Tax=Collinsella aerofaciens ATCC 25986 RepID=A4E8J9_9ACTN Length = 290 Score = 147 bits (370), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 93/281 (33%), Positives = 134/281 (47%), Gaps = 6/281 (2%) Query: 17 AEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN-SGERDRTHSIIK 75 A QG +SFE FPP+ T L L P FVSVT A SG T I Sbjct: 10 AASQGTAPISFEMFPPKGELTLDTAREVAGNLCKLSPSFVSVTCSAGGSGNGAATAPIAH 69 Query: 76 GIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDL 135 I + HLTC+ + ++ +Y G+ +I+ALRGDLP G+ + + ASD Sbjct: 70 MITSEFDTPSVAHLTCVGRSHADIAAKIDEYRTAGVENILALRGDLPAGATEDDKPASDY 129 Query: 136 V---TLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES 190 L+ E+ D F + AAYPE H + + +LK+K DAGA+ +TQ FFD E Sbjct: 130 AYARDLIPELVDAGFCVGAAAYPEGHIACEDLNLSVEHLKQKQDAGASFFVTQLFFDNEC 189 Query: 191 YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRK 250 + RFR+ AGI V I GI+P Q + M +P+ + ++ ++D E+ + Sbjct: 190 FYRFRELADKAGITVPITAGIMPFMGKSQISRMVFMCGASLPSPVIKILAKYENDPESLQ 249 Query: 251 LVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 G + A + L G H YT+NR ++ I LG Sbjct: 250 AAGVDYAARQLCDLKEHGADGLHLYTMNRPAIAATIMERLG 290 >UniRef50_B7G287 Methylenetetrahydrofolate reductase n=3 Tax=stramenopiles RepID=B7G287_PHATR Length = 634 Score = 145 bits (366), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 95/289 (32%), Positives = 146/289 (50%), Gaps = 21/289 (7%) Query: 10 DALNQSLAEVQ-----GQINVSFEFFPPRTSEMEQTLWNSIDRLSS-LKPKFVSVTYGAN 63 D+ SL + Q G SFEFFPP+T L IDR++ L P F+ VT+G++ Sbjct: 21 DSRQPSLHDCQLNFPGGNWYYSFEFFPPKTEAGLDNLLTRIDRMAQRLDPLFIDVTWGSD 80 Query: 64 SGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP 123 RT ++ + G++ HL+C T D+L + GI +I+ALRGD P Sbjct: 81 KTSA-RTMALASHAQKYLGVDVLLHLSCQGMTRDQLIRVLDQAKVLGIHNILALRGDPPK 139 Query: 124 G---------SGKPEMYASDLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRK 172 SG A DLV L++ F I+VA +PE HP + S + +L +LK K Sbjct: 140 AKKHWQVGDVSGGECERAIDLVRLIRNTYGDYFGIAVAGHPEGHPSSTSPEDELDHLKEK 199 Query: 173 VDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIP 232 + AGA+ I+QF +D E +L F RC GI I+PGI+P+ ++ + V +P Sbjct: 200 MRAGADFIISQFVYDTERFLDFCYRCRDVGIQCPILPGIMPIQSYSSFTRMTQYCGVSVP 259 Query: 233 AWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDF---HFYTLN 278 + + + + DD E K +G ++A +M + + + + HFYTLN Sbjct: 260 DEIWKRLEPIKDDDEAVKEIGCSLAAEMCRQILADPIAKIDGVHFYTLN 308 >UniRef50_B8BVS6 Methylenetetrahydrofolate reductase n=1 Tax=Thalassiosira pseudonana RepID=B8BVS6_THAPS Length = 383 Score = 145 bits (365), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 97/298 (32%), Positives = 146/298 (48%), Gaps = 28/298 (9%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDR-LSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 +VS E+FPPRT + + L +DR L + + +T+GA D + + +TG Sbjct: 25 HVSLEYFPPRTDQGVKNLHARMDRMLVNTNALYTDMTWGAGGSTADLSLELALHAH-KTG 83 Query: 83 LEAAPHLTCIDATPD-----ELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS---- 133 + HLTC + D + + ++ GIR+IVALRGD P G+ E A+ Sbjct: 84 HVSNMHLTCTNMEKDGDPVKAVHDALQQAYDGGIRNIVALRGDPP--EGEKEWTATEGGF 141 Query: 134 ----DLVTLLKEV--ADFDISVAAYPEVHPEAKSAQADLLN---------LKRKVDAGAN 178 DLV +++ F ISVA YPE HP S ++ + LK KVDAG + Sbjct: 142 SCALDLVKYIRKTFGDKFGISVAGYPEGHPNRISQLSEEEDEDYKKEMDYLKEKVDAGGD 201 Query: 179 RAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQM 238 ITQ FFD E + F + C + GI ++PG++ ++ + KK R+P + + Sbjct: 202 FIITQMFFDAEVFKTFVNDCRTWGITCPVVPGLMCINAYPGFKKMTKFCKTRVPKSLEER 261 Query: 239 FDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 D + DDA+ K G ++ + L GVK HFYTLN ++ Y I LG+ GL Sbjct: 262 MDAIKDDADAVKKFGVEFGAEISRNLLDSGVKILHFYTLNLEKVVYGITDELGITSGL 319 >UniRef50_Q17693 Probable methylenetetrahydrofolate reductase n=5 Tax=Chromadorea RepID=MTHR_CAEEL Length = 663 Score = 144 bits (364), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 92/279 (32%), Positives = 143/279 (51%), Gaps = 13/279 (4%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY--GANSGERDR---THSIIKGIKDR 80 S EFFPPR ++RLS FV +T+ G++ D+ + SI + D Sbjct: 74 SLEFFPPRFVNGVPNFLERVERLSEGGSVFVDMTWHMGSDPANVDKVTSSSSIAASMLDY 133 Query: 81 TGLEAAPHLTCIDATP-DELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY---ASDLV 136 G++ H+TC+ D L+ + + G+R I+ALRGDLPPG+ + + A D++ Sbjct: 134 CGVDTMLHMTCVQYNKADTLKHLEQAK-AMGLRSILALRGDLPPGTELEDTHQFRALDMI 192 Query: 137 TLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 ++E F I A YP HP+A S +ADL+ LK K DAGAN ITQ FF+ E++ +F Sbjct: 193 RWIREEYGNYFSIGCAGYPLGHPQAPSYKADLMYLKAKCDAGANFVITQLFFEAETFEKF 252 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGA 254 C GI IIPGI+P+ ++ K+ A ++ + IP + + + D + + G Sbjct: 253 VRDCREIGITQPIIPGIMPIMGYESIKRIAKLSQLEIPQHILDDLEPIKHDDDAVQKYGT 312 Query: 255 NIAMDMVKILSREGVK-DFHFYTLNRAEMSYAICHTLGV 292 ++M + L G H YT+NR I +LG+ Sbjct: 313 ERCIEMCRRLLDNGTAPSIHLYTMNREGSIREILKSLGL 351 >UniRef50_C4ZCX7 Methylenetetrahydrofolate reductase n=2 Tax=Firmicutes RepID=C4ZCX7_EUBR3 Length = 288 Score = 143 bits (360), Expect = 9e-33, Method: Compositional matrix adjust. Identities = 88/265 (33%), Positives = 139/265 (52%), Gaps = 5/265 (1%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN-SGERDRTHSIIKGIKDRTG 82 ++SFE FPP+ E + + ++ L P+++SVT+GA S ++T I K IK++ Sbjct: 13 SLSFEIFPPKKEEDFKNIDEMLEILCDCHPEYISVTFGAGGSSNNNKTIEIAKKIKNQYN 72 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE--MYASDLVTLLK 140 +E HLTC+ E+ R GI +I+ALRGD P E ++ASDL+ +K Sbjct: 73 VEPVVHLTCLCYNKAEIDEFTRQLSYEGIENILALRGDRNPNVPAKEDFLHASDLIKYIK 132 Query: 141 EVA--DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRC 198 + F I+ A YP++HPEA D+ NLK+KVDAGA ++Q FFD +++ F + C Sbjct: 133 DTTGDQFCIAGACYPDIHPEAADKVDDIKNLKKKVDAGAELLLSQLFFDNDTFFNFAEDC 192 Query: 199 VSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAM 258 AGI+V +IPGI+P N Q ++ M + P ++ D+ G + Sbjct: 193 RLAGINVPVIPGIMPCINAAQIQRMVTMCGAKFPEKFQKIVHRYGDNKAALFDAGMSYCE 252 Query: 259 DMVKILSREGVKDFHFYTLNRAEMS 283 + L V+ H YT+N ++ Sbjct: 253 SQIIELLANDVEGIHLYTMNNVRVA 277 >UniRef50_B7GRV7 Methylenetetrahydrofolate reductase n=16 Tax=Bifidobacteriaceae RepID=B7GRV7_BIFLI Length = 284 Score = 143 bits (360), Expect = 9e-33, Method: Compositional matrix adjust. Identities = 86/257 (33%), Positives = 134/257 (52%), Gaps = 4/257 (1%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANS-GERDRTHSIIKGIKDRTGLE 84 S E FPP+ + T+++++D L L P F+SVTYG + +R T I I G+ Sbjct: 7 SLEVFPPKRNAPVDTIYDTLDGLEGLNPDFISVTYGHGTHSDRTATARIAHTISKEYGIP 66 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG--KPEMYASDLVTLLKEV 142 A HLT + + ++ + G+ ++ALRGD G +ASDLV+ ++ + Sbjct: 67 AVAHLTALYSDKAKIDEALDMFEQAGVSAVLALRGDYIDGERLVGDFNHASDLVSYIRSM 126 Query: 143 A-DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSA 201 D + A YPE H ++ S D+ NLK KVDAG R I+Q F+D E + RF D+ +A Sbjct: 127 KPDLTVFGACYPEGHYQSGSLDQDIENLKIKVDAGVTRLISQLFYDNEDFYRFLDKARAA 186 Query: 202 GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMV 261 GI V I GI+PV K ++ A+ RIP + + + +DD ++ + G A + + Sbjct: 187 GITVPIEAGIMPVRGAKSVRRMAERNASRIPDKLDALLNRWEDDIQSLRTAGILYASEQI 246 Query: 262 KILSREGVKDFHFYTLN 278 L GV H Y++N Sbjct: 247 ADLVAHGVDGVHLYSMN 263 >UniRef50_C5L500 Methylenetetrahydrofolate reductase n=2 Tax=Perkinsus marinus ATCC 50983 RepID=C5L500_9ALVE Length = 631 Score = 142 bits (359), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 89/268 (33%), Positives = 138/268 (51%), Gaps = 19/268 (7%) Query: 39 QTLWNSIDRLSSLKPKFVSVTYGANSGER--DRTHSIIKGIKDRTGLEAAPHLTCIDATP 96 Q L+ +DR++ L P ++ VT+GA ++T I + GL+ HLTC + Sbjct: 4 QNLYERLDRMAELGPMWIDVTWGAGGSSSSSNKTFEICRNALTYHGLDVMMHLTCTQQSV 63 Query: 97 DELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM------YASDLVTLLK-EVAD-FDIS 148 +E+ + GIR+I+ALRGD P S + +A DLV ++ + D F I+ Sbjct: 64 EEIDEVLDKCKEVGIRNILALRGDAPTQSSEWRACQGGFSHAVDLVRHIRGKYGDYFCIA 123 Query: 149 VAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEII 208 VA YPE H EA+S + DL++LK KVDAGA+ ITQ F+D E + +F GI V I Sbjct: 124 VAGYPEGHLEAESIEEDLVHLKEKVDAGADLIITQLFYDTEVFFKFVAAVRKLGIQVPIF 183 Query: 209 PGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREG 268 PGI+P+ ++ KK + ++P +A + + D + K +G I + M + G Sbjct: 184 PGIMPIQSYSGFKKMTEFCKTKVPRAIADQLEQVKGDDQRVKDLGVEICVAMCSQIMSYG 243 Query: 269 VKD------FHFYTLNRAEMSYAICHTL 290 V HFYTLN + ++C + Sbjct: 244 VDHTHSSGGLHFYTLN---LESSVCRII 268 >UniRef50_D1BTF0 Methylenetetrahydrofolate reductase n=2 Tax=Actinomycetales RepID=D1BTF0_XYLCX Length = 323 Score = 140 bits (354), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 87/295 (29%), Positives = 149/295 (50%), Gaps = 29/295 (9%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 VSFE PPR + W + RL +++P FVSVTYGA G+R ++ + T + Sbjct: 16 TVSFELMPPRRPDAAPNFWETARRLVAVQPDFVSVTYGAGGGDRATARQVVATLLAGTPV 75 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE--------MYASDL 135 HLTC+ A+ +++ + D+ G+R +ALRGD P +P+ A +L Sbjct: 76 LPIAHLTCVGASREDVSEVIDDFLEAGVRAFLALRGD--PPKDQPDWRPPVDGVHSADEL 133 Query: 136 VTLLKEV------AD-----------FDISVAAYPEVHPEAKSAQA-DLLNLKRKVDAGA 177 V LL+EV AD I+VA +P+ +P A + +A ++ L K AGA Sbjct: 134 VRLLREVESARAAADPSSALRGAAHPLSIAVATFPDGNPAAGTTRAQEVQRLLAKQSAGA 193 Query: 178 NRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQ 237 + AITQ F++ +SY++F +AG+ + I+ G+LP + ++ ++ ++T V P + Sbjct: 194 SFAITQLFYEADSYIQFVAEARAAGVTIPILAGLLPTTEPRRLRRVEELTGVVAPPDLLD 253 Query: 238 MFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 D L DAE + G ++++ + + G H YT N+ + + +G+ Sbjct: 254 ALDAL-PDAEAQHEYGIARSVELARAVLDAGAPGLHVYTFNKHRPALDLLAGIGL 307 >UniRef50_C7QYL7 Methylenetetrahydrofolate reductase n=2 Tax=Actinomycetales RepID=C7QYL7_JONDD Length = 339 Score = 140 bits (354), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 88/282 (31%), Positives = 136/282 (48%), Gaps = 25/282 (8%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 VSFE PPR WN+ +L P FVSVTYGA G+RD ++++ + T + Sbjct: 17 TVSFELMPPRNPAAAPKFWNTARKLVEAHPDFVSVTYGAAGGDRDSARTVVETLVQHTNV 76 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP---PGSGKPE---MYASDLVT 137 HLTC+ AT D + D+ G R +ALRGD P P P + + +L+ Sbjct: 77 LPIAHLTCVGATRDNVADTIDDFLAAGARTFLALRGDPPKDQPDWAPPTNGVVSSLELIA 136 Query: 138 LLKEV------AD-----------FDISVAAYPEVHPEAKSA-QADLLNLKRKVDAGANR 179 LL++V AD I+VA +PE + +A + + + L +K AGAN Sbjct: 137 LLRDVEAQRCQADASEALRGAMKPLTIAVATFPEGNRDAGTTREQEAARLLQKQQAGANF 196 Query: 180 AITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMF 239 AITQ F+ +Y F D S G+ + I+ GILP+++ ++ ++ +T V +P +A Sbjct: 197 AITQLFYTASAYTEFVDVARSLGVTIPIVAGILPMTDPQRLRRLEQLTGVPVPLELAAQL 256 Query: 240 DGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAE 281 D + R G ++D+ + G H YT N+ E Sbjct: 257 DAIASP-HVRHSHGIAASVDLANAVLDSGAPGLHIYTFNKHE 297 >UniRef50_A9UZU5 Methylenetetrahydrofolate reductase n=1 Tax=Monosiga brevicollis RepID=A9UZU5_MONBE Length = 332 Score = 140 bits (353), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 98/311 (31%), Positives = 141/311 (45%), Gaps = 38/311 (12%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 +G+ VSFEFFPPRT + +L + I R + +P F+ +T+GA D T + + Sbjct: 16 KGEKFVSFEFFPPRTDDGVTSLMSRIQRYNDQQPLFMDMTWGAGGSTSDLTLDLCTRMVK 75 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY------AS 133 G A HLTC + +++ + + GIR+IVALRGD P G E A Sbjct: 76 ECGANANMHLTCTNMPSEKIDIALKGARDAGIRNIVALRGDPPAGEEAWEAVEGGYSCAL 135 Query: 134 DLVT-LLKEVAD-FDISVAAYPEVHPEAKSA----------------------------- 162 DLV + KE D F I+V+ YPE HP A + Sbjct: 136 DLVKHIRKEHGDFFSIAVSGYPEGHPNAITKVQDEAELTESERERVIEMEDGLYVCRDGD 195 Query: 163 -QADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAK 221 Q ++ LK KVDAGA+ ITQ FD Y F C + GI++ ++PGI+ + N K Sbjct: 196 FQKEMEYLKAKVDAGADLIITQMVFDAPVYGAFLKACKAYGINIPVVPGIMCIQNAGGFK 255 Query: 222 KFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAE 281 + R PA + + DD E + V + + L G HFYTLN + Sbjct: 256 RMTAFCKSRTPAALRAAVEAAGDDKEAIRKVAVEHGAQLCRDLQAAGAPGLHFYTLNLEK 315 Query: 282 MSYAICHTLGV 292 ++ AI L + Sbjct: 316 VTLAILDALNL 326 >UniRef50_C4R2L4 Methylenetetrahydrofolate reductase n=1 Tax=Pichia pastoris GS115 RepID=C4R2L4_PICPG Length = 596 Score = 140 bits (353), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 90/281 (32%), Positives = 151/281 (53%), Gaps = 19/281 (6%) Query: 16 LAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIK 75 + E++G+ SFEFFPP+T + L + R+S L P FV+VT+GA +T + Sbjct: 8 IKELKGEPFYSFEFFPPKTDNGLRNLLARLGRMSMLNPLFVTVTWGAGGTTSSKTLDLAI 67 Query: 76 GIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM----- 130 + L HLTC + + + + ++NGI++I+ALRGD P + + + Sbjct: 68 TCQKDLDLTTCIHLTCTNTSKKLIDNALKAAYDNGIKNILALRGDPPREAQEVAVDQDFK 127 Query: 131 YASDLVTLLK-EVAD-FDISVAAYPEVHPEA-----KSAQADLLNLKRKVDAGANRAITQ 183 YA DLV ++ + D F I VAAYPE H E +S D+ L K++AGA+ +TQ Sbjct: 128 YAIDLVRYIRGQYGDYFCIGVAAYPEGHVEGNDDSEQSIDHDMPYLLEKINAGADFVVTQ 187 Query: 184 FFFDVESYLRFRDRCVS-AGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMF--D 240 F+D + + F + G DV +IPG++P++ ++ ++ ++++ IP + Q+F D Sbjct: 188 LFYDADKFCTFYNTLKQRLGRDVVVIPGLMPINTYQLFQRATNLSHASIPPAVGQLFPPD 247 Query: 241 GLDDDAETRKLVGANIAMDMVKILSREG---VKDFHFYTLN 278 DD + + +G + +D+V + E V +HFYTLN Sbjct: 248 VRHDDDKVKD-IGVKLMIDIVDQIYNETHGEVNGYHFYTLN 287 >UniRef50_P46151 Methylenetetrahydrofolate reductase 1 n=10 Tax=Saccharomycetaceae RepID=MTHR1_YEAST Length = 657 Score = 140 bits (352), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 95/296 (32%), Positives = 154/296 (52%), Gaps = 30/296 (10%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 +S EFFPP+T + L + R+++L P F++VT+GA ++T ++ + + Sbjct: 15 ISLEFFPPKTELGTRNLMERMHRMTALDPLFITVTWGAGGTTAEKTLTLASLAQQTLNIP 74 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG--------SGKPEMYASDLV 136 HLTC + + +N GIR+I+ALRGD P G + P YA DLV Sbjct: 75 VCMHLTCTNTEKAIIDDALDRCYNAGIRNILALRGDPPIGEDWLDSQSNESPFKYAVDLV 134 Query: 137 TLLKEVA--DFDISVAAYPEVHPEAKSAQ------ADLLNLKRKVDAGANRAITQFFFDV 188 +K+ F + VAAYPE H E ++ DL+ LK KV+AGA+ ITQ F+DV Sbjct: 135 RYIKQSYGDKFCVGVAAYPEGHCEGEAEGHEQDPLKDLVYLKEKVEAGADFVITQLFYDV 194 Query: 189 ESYLR----FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRI-PAWMAQMFDGLD 243 E +L FR+R D+ + PG++P++++ + A +++ I PA +++ + Sbjct: 195 EKFLTFEMLFRERISQ---DLPLFPGLMPINSYLLFHRAAKLSHASIPPAILSRFPPEIQ 251 Query: 244 DDAETRKLVGANIAMDMVK-ILSREG--VKDFHFYTLNRAEMSYAICHTLGVRPGL 296 D K +G +I +++++ I R +K FHFYTLN + AI + P L Sbjct: 252 SDDNAVKSIGVDILIELIQEIYQRTSGRIKGFHFYTLN---LEKAIAQIVSQSPVL 304 >UniRef50_C0QAY2 Methylenetetrahydrofolate reductase n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QAY2_DESAH Length = 293 Score = 140 bits (352), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 88/272 (32%), Positives = 143/272 (52%), Gaps = 6/272 (2%) Query: 15 SLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSII 74 +L + Q +VSFEFFPPR + E + + +D LS+L P ++S+T+GA + + + Sbjct: 5 NLYKNQSDPSVSFEFFPPRDDKAESSFYGVVDALSALNPAYMSMTFGAGGSTSEGSFQAV 64 Query: 75 KGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG---KPEMY 131 K + L ++ P E+ + Y G+ I +RGD P G PE + Sbjct: 65 KRMMIEKNLPMVAYIAGYGLGPHEITEVLDRYKALGVETIFVIRGDKPRTDGFTPHPESF 124 Query: 132 A--SDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVE 189 A SDL+ + + DFD+ A YPE H +A+S + D+ L+ K D GA + Q+F+D + Sbjct: 125 AHASDLIRFISDRYDFDLGCAGYPEGHVQAESLEKDVEYLRLKQDNGAQYVVAQYFYDND 184 Query: 190 SYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGL-DDDAET 248 S+ R+ D C +GI + IIPGI+P+ K + + +P + + D L +D +E Sbjct: 185 SFYRYVDLCRKSGITIPIIPGIMPIYTVKLTRMLCKLCGSTLPTGLREKLDSLTNDKSEA 244 Query: 249 RKLVGANIAMDMVKILSREGVKDFHFYTLNRA 280 +G N A D + L +GV HFYT++R+ Sbjct: 245 VADLGVNFAFDQCRDLVLKGVDGLHFYTMDRS 276 >UniRef50_C6PS47 Methylenetetrahydrofolate reductase n=1 Tax=Clostridium carboxidivorans P7 RepID=C6PS47_9CLOT Length = 285 Score = 139 bits (351), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 84/279 (30%), Positives = 140/279 (50%), Gaps = 4/279 (1%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 ++ +++ SFE FPP++ + + L ++++ L P F+S TYGA R I K IK Sbjct: 7 MKKKMSFSFEVFPPKSDKPIEPLLDTLEHLYEFNPDFISCTYGAGGTNAGRNMEICKAIK 66 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASDL 135 D H TCI T ++++ + Y + G+ HI+ALRGDLP G YA++L Sbjct: 67 DSGKSIPVTHYTCIGNTKEKMKQELQRYLDMGVDHILALRGDLPKGWEGTRGDFNYANEL 126 Query: 136 VTLLK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 V +K F I+V+ PE H E+ S D+ +L+ K DAGA+ +TQ DV+ Y + Sbjct: 127 VQYIKSNFPKFTIAVSGNPEKHFESYSFDEDITHLRIKQDAGADYIMTQLCHDVDQYCWW 186 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGA 254 ++ AG+ + I G++P+ + + A IP +A++ D+ E K G Sbjct: 187 VEKIRKAGVSMPIDVGVMPILSKDPTIRMAVSNGSSIPRDLAEIIARYGDNPEDFKKAGK 246 Query: 255 NIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 + + G+ H Y+LN+ + I +G+R Sbjct: 247 EYSAKQIFKFINAGIDGLHIYSLNKWQDVTDIIKDVGIR 285 >UniRef50_Q5KN82 Methylenetetrahydrofolate reductase n=1 Tax=Filobasidiella neoformans RepID=Q5KN82_CRYNE Length = 633 Score = 138 bits (348), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 94/282 (33%), Positives = 142/282 (50%), Gaps = 18/282 (6%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSS---LKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 ++EFFPP T L + I RL+S P VSVT+GA +++ + + + D G Sbjct: 17 NYEFFPPLTDPGFVNLLDRIRRLTSSPFQAPLAVSVTWGAGGSTAEKSLELAQQVVD-MG 75 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP--------PGSGKPEMY--A 132 +E HLTC + D++ R + GI +I+ALRGD P P S P+ + A Sbjct: 76 VEVILHLTCTNMPKDKVDFALRRCKDLGISNILALRGDPPREEEYAINPTS-TPDFFKHA 134 Query: 133 SDLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES 190 DLV +++ F I VA YP HP+++S + D K K DAGA+ +TQ F+DV+ Sbjct: 135 DDLVRYIRQTHGDYFCIGVAGYPNPHPDSESEEEDFKWFKAKCDAGADFIVTQLFYDVDV 194 Query: 191 YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRK 250 +L + C + GI+ IIPGI+P+ N+ ++ ++T +P + + D T K Sbjct: 195 FLEWVKTCRARGINQPIIPGIMPIQNYASFRRLVNLTKCPVPDSITSDLQPISSDDATVK 254 Query: 251 LVGANIAMDMVKILSREG-VKDFHFYTLNRAEMSYAICHTLG 291 GA +A MV + G V H TLN + I LG Sbjct: 255 RYGAELATKMVSQIIESGLVPGVHLCTLNLEKSVRMILDNLG 296 >UniRef50_C2EUU9 Methylenetetrahydrofolate reductase n=2 Tax=Lactobacillus RepID=C2EUU9_9LACO Length = 281 Score = 137 bits (345), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 85/273 (31%), Positives = 134/273 (49%), Gaps = 8/273 (2%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIK---GIKDRT 81 +S+E FPP ++ L + L L P F+SVT NS + H ++ +++ Sbjct: 4 LSYEVFPPNSTVGINHLNQVLTSLRDLSPDFISVT--CNSNTKQLAHETVRVADYVENDC 61 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE--MYASDLVTLL 139 + A HL + +++ I + ++ LRGD P K +ASDL+ + Sbjct: 62 QVPAMAHLPAWYLSREDVDRILEQLRVCHVDRVLVLRGDERPKLEKKTDFAHASDLIAYI 121 Query: 140 KE-VADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRC 198 K+ DF I+ A YPE HPE+ S ++ +LK KV++G ++ ITQ F D SY RFR+ C Sbjct: 122 KQNYPDFQITGACYPEKHPESLSMVDEIQHLKLKVESGCDQIITQLFLDNHSYYRFRELC 181 Query: 199 VSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAM 258 GIDV II GI+PV N +QA + + V +P + D + K G A+ Sbjct: 182 AIGGIDVPIIAGIMPVVNERQANRILRTSAVTVPEKFKDILAKYHDHPQALKQAGITYAI 241 Query: 259 DMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 D + L V H YT+N ++ + + +G Sbjct: 242 DQIVDLVTNDVSGIHLYTMNHSDTARQVKQNIG 274 >UniRef50_D1ZNB9 Methylenetetrahydrofolate reductase n=1 Tax=Sordaria macrospora RepID=D1ZNB9_SORMA Length = 758 Score = 136 bits (343), Expect = 7e-31, Method: Compositional matrix adjust. Identities = 96/286 (33%), Positives = 146/286 (51%), Gaps = 29/286 (10%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLS-SLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 Q S EFFPP+T+ L + ++R++ L+P FV+VT+GA ++ + + + Sbjct: 91 QHYFSLEFFPPKTAMGFANLRDRLERMARGLRPLFVNVTWGAGGSTAQKSLELAEICQRE 150 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP------------PGSGKP 128 GL HLTC + + L D GIR+I+ALRGD P P + Sbjct: 151 LGLTTCLHLTCTNMSRRLLDKTLEDAKVLGIRNILALRGDPPRAAEYHDENDPEPTDDEE 210 Query: 129 EMYASDLVTLLKEVAD--FDISVAAYPE-----VHPEAKSAQADLLNLKRKVDAGANRAI 181 +A+DLV +K+ F I VAAYPE HP +S + DL L KV AGA+ + Sbjct: 211 FSWAADLVRYIKKNHGDYFCIGVAAYPEGHADQSHPREQSLEHDLPYLVEKVQAGADFIM 270 Query: 182 TQFFFDVESYLRF----RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQ 237 TQ FFD+++Y F R A DV IIPG++P+ +++ K+ +++ +IP + Sbjct: 271 TQLFFDIDAYEHFENTLRGHPSGAFKDVLIIPGLMPIQSYQMIKRTTKLSHAKIPPALMA 330 Query: 238 MFDGLDDDAETRKLVGANIAMDMV----KILSREGV-KDFHFYTLN 278 D + D E K+ G I +++ +I SR + FHFYTLN Sbjct: 331 RLDAVKGDDEKVKMEGVAIVSEIIERIKEIKSRTHTPRGFHFYTLN 376 >UniRef50_A8NEV2 Methylenetetrahydrofolate reductase n=2 Tax=Agaricales RepID=A8NEV2_COPC7 Length = 617 Score = 136 bits (343), Expect = 8e-31, Method: Compositional matrix adjust. Identities = 88/283 (31%), Positives = 146/283 (51%), Gaps = 15/283 (5%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEA 85 +FEFFPPRT + + L I RLS+L P +S+T+GA ++R+ + + + L+ Sbjct: 18 TFEFFPPRTDQGTENLIARISRLSTLDPLAISITWGAGGSTKERSLDLASITQSQHRLDT 77 Query: 86 APHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS-----GKPEM-YASDLVTLL 139 HLTC + + + +D + GI I+ALRGD P G P +A DLV + Sbjct: 78 ILHLTCTNMEQGLIDDVLKDVKDRGIETILALRGDPPRGEEEWIPSDPRFTHAIDLVKYI 137 Query: 140 KEVAD----FDISVAAYPEVHPEAKSAQ-ADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 + + F I VA + H E+ ++ +L +LK KVDAGA+ +TQ F+DV+ +L++ Sbjct: 138 RGSQEYSSHFCIGVA---DGHTESTCSEDEELEHLKAKVDAGADFIVTQLFYDVDRFLQW 194 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGA 254 + + GI V IIPGI+P+ + + + ++P+ + + +D + K G Sbjct: 195 LKKVRAKGITVPIIPGIMPIQTYATFARLTKLCGTKVPSTLEADLLPIKNDDQLVKDYGV 254 Query: 255 NIAMDMVKILSRE-GVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 A+ + L E G++ FHF TLN + + L R G+ Sbjct: 255 KYAVKTIHRLRNEGGIQGFHFCTLNLEKSVQRVLEELKWRTGV 297 >UniRef50_B7GB47 Methylenetetrahydrofolate reductase (Fragment) n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B7GB47_PHATR Length = 376 Score = 135 bits (341), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 102/340 (30%), Positives = 150/340 (44%), Gaps = 70/340 (20%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRL-SSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G+ VS E+FPPRT+E Q L + R+ +L+P F +T+GA + + + Sbjct: 38 GKPFVSLEYFPPRTAEGVQNLHARMHRMRDTLQPAFTDMTWGAGGSTAELSLQLAL-YAH 96 Query: 80 RTGLEAAPHLTCID--------------------------ATPDE-LRTIARDYWNNGIR 112 TG A H+TC + A P E LR + + GIR Sbjct: 97 NTGHVANLHMTCTNLDSGKSSTSTSSSSEHNGNASDDVASADPRETLRRALQQAHDGGIR 156 Query: 113 HIVALRGDLPPG------SGKPEMYASDLVTLLKEV----ADFDISVAAYPEVHPEAKSA 162 ++VALRGD P G + A DLV ++ + ADF ++VA YPE HP A S Sbjct: 157 NLVALRGDPPAGQETWTATEGGFTCALDLVEFIRSLPDIGADFHLAVAGYPEGHPNAISE 216 Query: 163 QAD------------------------------LLNLKRKVDAGANRAITQFFFDVESYL 192 AD + LK+KVDAG + +TQ FFD +L Sbjct: 217 IADPTTLTAAEAARASVTDGKTYCCLDADYHKEMEYLKKKVDAGGDMIMTQMFFDAAVFL 276 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV 252 +F + C + GI V I+PG++ ++ + K A R+P + + + DDA K Sbjct: 277 QFVEDCRAWGITVPIVPGLMCINAYAGFVKMAKFCKTRVPETLRARMEAIKDDAAAVKAF 336 Query: 253 GANIAMDMVKILSREG-VKDFHFYTLNRAEMSYAICHTLG 291 G ++M + L G V HFYTLN ++ Y + LG Sbjct: 337 GVEFGVEMCRTLLASGHVSVLHFYTLNLEKVVYGVLDALG 376 >UniRef50_A8XGR9 Methylenetetrahydrofolate reductase n=1 Tax=Caenorhabditis briggsae RepID=A8XGR9_CAEBR Length = 724 Score = 135 bits (339), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 91/295 (30%), Positives = 140/295 (47%), Gaps = 29/295 (9%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY--GANSGERDR---THSIIKGIKDR 80 S EFFPPR ++RLS FV +T+ G++ D+ + SI + D Sbjct: 109 SLEFFPPRFVNGVPNFLERVERLSEGGSVFVDMTWHMGSDPANIDKVTSSSSIAASMLDY 168 Query: 81 TGLEAAPHLTCIDATP-DELRTIARDYWNNGIRHIVALRGDLPPG--------------- 124 G++ H+TC+ D L+ + + G+R I+ALRGDLPPG Sbjct: 169 CGVDTMLHMTCVQYNKADTLKHLEQAK-AMGLRSILALRGDLPPGVCCGIVSNSFFIFMF 227 Query: 125 ----SGKPEMYASDLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGAN 178 + A D++ ++E F I A YP HP+A S +ADL LK K DAGAN Sbjct: 228 QTELEDTNQFRALDMIRWIREEYGDYFSIGCAGYPLGHPQAPSYKADLQYLKAKCDAGAN 287 Query: 179 RAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQM 238 ITQ FF+ E++ +F C GI IIPGI+P+ ++ K+ A ++ + IP + + Sbjct: 288 FVITQLFFEPETFEKFVADCREIGITKPIIPGIMPIMGYESIKRIAKLSQLEIPEHILED 347 Query: 239 FDGLDDDAETRKLVGANIAMDMV-KILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 + + D + + G ++M ++L H YT+NR I LG+ Sbjct: 348 LEPIKHDDDAVQKYGTERCIEMCRRLLDNGSAPSIHLYTMNREGSIREILKALGL 402 >UniRef50_C5DIA7 Methylenetetrahydrofolate reductase n=2 Tax=Saccharomycetaceae RepID=C5DIA7_LACTC Length = 660 Score = 134 bits (338), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 96/294 (32%), Positives = 150/294 (51%), Gaps = 27/294 (9%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 +S EFFPP+T +Q L + R+++L P F+++T+GA +T + + + Sbjct: 35 ISLEFFPPKTKLGKQNLTARMTRMTALNPLFITITWGAGGTTAKKTLELATVAQRELNVP 94 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP-------PGSGKPEMYASDLVT 137 HLTC + + + + IR+I+ALRGD P P +A DLV Sbjct: 95 VCMHLTCTNTNKEIIDEALKLAHEADIRNILALRGDPPVGEEWETPSESSEFQHAVDLVR 154 Query: 138 LLKEVA--DFDISVAAYPEVHPE------AKSAQADLLNLKRKVDAGANRAITQFFFDVE 189 +KE DF + VAAYPE H E A+ + DL LK KVDAGA+ ITQ F+DVE Sbjct: 155 YIKEKYNDDFCVGVAAYPEGHCEGEADGVAQDPRRDLGFLKEKVDAGADFVITQLFYDVE 214 Query: 190 SYLRFRDRC---VSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIP-AWMAQMFDGLDDD 245 +L F VSA D+ + PG++P++++ + A +++ IP A ++ D Sbjct: 215 KFLSFEQMFRNEVSA--DIPLFPGLMPINSYLLFNRAAKLSHASIPQAIRDRLPQEYHSD 272 Query: 246 AETRKLVGANIAMDMVKILSR--EG-VKDFHFYTLNRAEMSYAICHTLGVRPGL 296 + +G +I ++MV+ + + EG +K HFYTLN + AI + P L Sbjct: 273 DNKVRAIGVDILVEMVEEIYKRTEGRIKGIHFYTLN---LEKAIAQIVTKSPSL 323 >UniRef50_B9WCV3 Methylenetetrahydrofolate reductase n=10 Tax=Saccharomycetales RepID=B9WCV3_CANDC Length = 640 Score = 134 bits (337), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 88/275 (32%), Positives = 145/275 (52%), Gaps = 27/275 (9%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 VSFEFFPP+T + L ++R+S+ P F++VT+GA +++ + ++ G+ Sbjct: 18 VSFEFFPPKTDSGFRNLLARLNRMSAFNPLFITVTWGAGGSTSEKSLDLAATCQNEIGIT 77 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY---------ASDL 135 HLTC + + + G+R+I+ALRGD P + E Y A DL Sbjct: 78 TVLHLTCTNTNKEVIDQALSKAKAAGVRNILALRGDPP----RTEEYWTPNCDFSGAVDL 133 Query: 136 VTLLKE-VAD-FDISVAAYPEVHPE-----AKSAQADLLNLKRKVDAGANRAITQFFFDV 188 V ++E D F I VAAYPE H + +++ Q D+ L KV AGA+ ITQ FFDV Sbjct: 134 VKYIRENYGDYFCIGVAAYPEGHVDGSDISSQNPQKDIPFLVEKVKAGADFIITQLFFDV 193 Query: 189 ESYLRF----RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDD 244 E ++ F ++ GI +IPG++P++ +K + A +++ IP + + D + Sbjct: 194 EKFIAFEKLLKEHDELKGI--PLIPGLMPITTYKVFNRAAKLSHASIPRGILKQVDQVCH 251 Query: 245 DAETRKLVGANIAMDMV-KILSREGVKDFHFYTLN 278 D K +G +I +++ +I ++ +HFYTLN Sbjct: 252 DDNAVKALGVDILTEIIDRIDKSTNIRGYHFYTLN 286 >UniRef50_B2GHG1 Methylenetetrahydrofolate reductase n=1 Tax=Kocuria rhizophila DC2201 RepID=B2GHG1_KOCRD Length = 331 Score = 133 bits (335), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 91/289 (31%), Positives = 143/289 (49%), Gaps = 25/289 (8%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 VSFE FPPR + T+W SID ++ P F SVT+G +SG R + ++ ++ T Sbjct: 35 VSFEVFPPRPTTDPDTVWRSIDAMAQAGPDFFSVTHG-HSGGRGVSREALRHLRRTTRTP 93 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK---PEM---YASDLVTL 138 H TC L ++G+R ++ALRGD P G+G+ P AS+LV L Sbjct: 94 VMAHFTCGGTDRAGLERSVEHLLDDGVRDLLALRGDPPLGAGEWVTPPGGIGRASELVRL 153 Query: 139 LKEVA-------------DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFF 185 +++V +SVA YP + +ADL +L K +AGA+ AITQ Sbjct: 154 IRDVERRRFGDGFRPGTRPLSVSVACYPSPA-RGRDFEADLASLWEKQEAGADYAITQVL 212 Query: 186 FDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFD-GLDD 244 ++ E Y F +R S GI + ++ G++P++N K+ ++ ++T V +P + + G D Sbjct: 213 YEPEDYAAFLERARSEGIHIPVVAGLMPLTNPKRLQRMTEITGVPVPERLTRFLTAGSPD 272 Query: 245 DAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 + R G + ++ L G FH YT NR + + I L VR Sbjct: 273 ELRHR---GTAATLTLIDDLLDLGCAGFHLYTFNRPDAALTILEHLRVR 318 >UniRef50_C9L8P5 Methylenetetrahydrofolate reductase n=1 Tax=Blautia hansenii DSM 20583 RepID=C9L8P5_RUMHA Length = 311 Score = 133 bits (335), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 91/291 (31%), Positives = 142/291 (48%), Gaps = 23/291 (7%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 +SFE FPP+T + + L +I+ L KP+++S TYGA + + K IKD G Sbjct: 19 LSFELFPPKTDKGMENLPGTIEHLCKYKPEYISCTYGAGGTNVGKNMDVCKMIKD-AGTI 77 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP---PGSGKPEMYASDLVTLL-K 140 H TCI T + ++ ++Y +NG+ H++ALRGDLP G+G YA+DLV + K Sbjct: 78 PVTHFTCIGNTAEGIKDQLQNYLDNGVDHMLALRGDLPFGWTGTGGDFAYATDLVAYVRK 137 Query: 141 EVAD-FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199 E D +I+VA PE H +S +AD+ LK+K D GA+ +TQ +D+E + + D Sbjct: 138 EFGDKIEIAVAGSPEGHISCRSLEADIAVLKQKQDNGADYIMTQLCWDMEQFKYWLDAIR 197 Query: 200 SAGIDVEIIPGILPVSNFKQAKKFADMTNVRI-PAWMAQMF------------DGLDDDA 246 AGI + + GI+P+ + A N + P + ++ D D D Sbjct: 198 CAGITMPVDVGIMPILDQAATINMALSRNACVMPRELCEIISKNWIFPNPFVQDPFDADV 257 Query: 247 ETRKL----VGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 E +K G + + G+ H Y LN+ + I G+R Sbjct: 258 EGKKARFKEAGIEYTIRQIDEYRACGIDGIHLYALNKWKDVSEIIDRSGLR 308 >UniRef50_C6BZ56 Methylenetetrahydrofolate reductase n=1 Tax=Desulfovibrio salexigens DSM 2638 RepID=C6BZ56_DESAD Length = 293 Score = 133 bits (334), Expect = 9e-30, Method: Compositional matrix adjust. Identities = 84/266 (31%), Positives = 123/266 (46%), Gaps = 11/266 (4%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEA 85 SFEFFPP+ RL++LKP F SVTYGA D + I +K G++ Sbjct: 15 SFEFFPPKDKSTWPVFMERAARLAALKPLFASVTYGAGGTSHDNSLEICSLLKKDMGIDI 74 Query: 86 APHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL---PPGSGKPEMY-ASDLVTLLKE 141 HLTC+ A+ + G+ I+AL GD G G+ + ASDLV + + Sbjct: 75 LAHLTCVGASEQSIDEFVSRLCETGVSDILALGGDGVKDANGEGQSRFFHASDLVEYVDD 134 Query: 142 -VADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVS 200 ++ I+VA YP HPE+ S D+ K+ GA+ +TQ FFD Y + DR Sbjct: 135 KFSEVGIAVAGYPGGHPESPSIAKDIEIHNSKLSKGADFTMTQLFFDNRLYFDYVDRLAE 194 Query: 201 AGIDVEIIPGILPVSNFKQAKKFADMTNVRIPA----WMAQMFDGLDDDAETRKLVGANI 256 G +IPG+LP+ + ++ + IP + + F+ D+A G + Sbjct: 195 LGSTAPVIPGVLPIQSLSSLRRIMSLCGAGIPGDLYCGVEKAFEKGGDEAVME--FGFDF 252 Query: 257 AMDMVKILSREGVKDFHFYTLNRAEM 282 A + L G H Y+LNRA M Sbjct: 253 ARKQISDLLDRGAPGVHIYSLNRAAM 278 >UniRef50_Q2HBA5 Methylenetetrahydrofolate reductase n=2 Tax=Leotiomyceta RepID=Q2HBA5_CHAGB Length = 643 Score = 132 bits (332), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 97/302 (32%), Positives = 152/302 (50%), Gaps = 31/302 (10%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLS-SLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 GQ S EFFPP+T+ L + +DR++ +L+P FV+VT+GA ++ + + + Sbjct: 33 GQDYFSLEFFPPKTAMGFSNLRSRLDRMARALRPLFVNVTWGAGGSTATKSLELAEICQR 92 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---------- 129 GL HLTC + + + D GIR+I+ALRGD PP + Sbjct: 93 ELGLTTCLHLTCTNMSRRLIDKALDDAKALGIRNILALRGD-PPRRAEYRDANEPEPEEE 151 Query: 130 ---MYASDLVTLLKEVAD--FDISVAAYPE-----VHPEAKSAQADLLNLKRKVDAGANR 179 +A DLV +++ F I VAAYPE HP +S + DL L K AGA+ Sbjct: 152 EEFSWAVDLVRYIRKTHGDYFCIGVAAYPEGHADESHPLGQSLEHDLPYLVEKTQAGADF 211 Query: 180 AITQFFFDVESYLRF----RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWM 235 +TQ FFDVE+Y F R+ A ++ I+PG++P+ +++ K+ +++ IP + Sbjct: 212 IMTQLFFDVEAYNHFEKTLREHPSGAFKNITILPGLMPIQSYQMIKRTTKLSHANIPDSL 271 Query: 236 AQMFDGLDDDAETRKLVGANIAMDMV----KILSR-EGVKDFHFYTLNRAEMSYAICHTL 290 D + D E K VG +I ++V ++ SR + + FHFYTLN + I Sbjct: 272 MARLDAVKGDDEKVKEVGVDILSEIVEQIKEVKSRTDEPRGFHFYTLNLEKAVSFIVERT 331 Query: 291 GV 292 G+ Sbjct: 332 GL 333 >UniRef50_D1BI58 Methylenetetrahydrofolate reductase n=2 Tax=Micrococcineae RepID=D1BI58_SANKS Length = 354 Score = 132 bits (332), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 81/286 (28%), Positives = 141/286 (49%), Gaps = 29/286 (10%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 +SFE PPR W+++D L + +P FVSVTYGA G+R ++++ I + + Sbjct: 31 TLSFELMPPRNPAAAPKFWSTVDHLVAARPDFVSVTYGAAGGDRTTAQTVVRRILEHAPV 90 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY--------ASDL 135 HLTC+ A+ D + + ++ G+R +ALRGD P +P+ + +L Sbjct: 91 LPIAHLTCVGASRDNVAEVIDEFLAEGVRSFLALRGD--PPRDQPDWQPHPDGVNSSDEL 148 Query: 136 VTLLKEVA-----------------DFDISVAAYPEVHPEAKSAQA-DLLNLKRKVDAGA 177 V LL+EV I+VA + + + A + ++ ++ L K AGA Sbjct: 149 VALLREVEAQRCAEDPSSALRSAARPLTIAVATFLDGNAAAGTTRSQEVQRLLEKQQAGA 208 Query: 178 NRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQ 237 + AITQ F+D +SY+ F D AG+ + I+ G+LP+++ + + +T V P + + Sbjct: 209 DFAITQLFYDADSYVGFVDEARRAGVTLPILAGLLPMTDPARLARVETLTGVPAPKALVR 268 Query: 238 MFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMS 283 + L D A R G ++++ + + G H YT N+ E + Sbjct: 269 DLESLTDPA-ARHAHGIRASVELAEAVLAAGAPGLHIYTFNKHEAA 313 >UniRef50_C4Y9Q4 Methylenetetrahydrofolate reductase n=1 Tax=Clavispora lusitaniae ATCC 42720 RepID=C4Y9Q4_CLAL4 Length = 601 Score = 131 bits (330), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 93/284 (32%), Positives = 147/284 (51%), Gaps = 23/284 (8%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 SFEFFPP+T + L + R+ L P FVSVT+GA +++ + + G+ Sbjct: 17 CSFEFFPPKTDAGFRNLLARLHRMRDLNPLFVSVTWGAGGSTSEKSLELAVTCQQLLGIS 76 Query: 85 AAPHLTCID---ATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK---PEM---YASDL 135 HLTC + A D+ + A+ GIR+I+ALRGD PP + + PE A DL Sbjct: 77 TVLHLTCTNTNKAIIDDALSRAK---AAGIRNILALRGD-PPRTREYWTPECSFRTAVDL 132 Query: 136 VTLLK-EVAD-FDISVAAYPEVHPEA-----KSAQADLLNLKRKVDAGANRAITQFFFDV 188 V ++ + D F I VA YPE H + + + DL L+ KV AGA+ +TQ FFD Sbjct: 133 VRYIRAQYGDYFCIGVAGYPEGHVDGSDGAEQDPKRDLPYLEEKVAAGASFVVTQMFFDA 192 Query: 189 ESYLRFRDRCVSAGI--DVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDA 246 + Y+ F ++ + DV +IPG++P++ +K + +++ +PA +A+ D Sbjct: 193 DKYVAFEKMVRASPVLKDVVLIPGLMPITTYKVFTRATKLSHASVPAAVAEQLSSAAVDD 252 Query: 247 ETRKLVGANIAMDMVKILS-REGVKDFHFYTLNRAEMSYAICHT 289 + K +G ++ +V +S R + FHFYTLN AI + Sbjct: 253 DQVKKIGVDVLSQLVADVSARSAARGFHFYTLNLERAVAAIVES 296 >UniRef50_C5FI42 Methylenetetrahydrofolate reductase n=1 Tax=Microsporum canis CBS 113480 RepID=C5FI42_NANOT Length = 715 Score = 130 bits (328), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 95/285 (33%), Positives = 143/285 (50%), Gaps = 39/285 (13%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLS-SLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 S EFFPP+T L ++R+S +L+P FV+VT+GA R+ + + + + GL Sbjct: 19 SLEFFPPKTQMGSSNLQARLERMSQALRPLFVTVTWGAGGSTAARSLELAEICQRQLGLT 78 Query: 85 AAPHLTC-------IDATPDELRTIARDYWNNGIRHIVALRGDLPPG----------SGK 127 HLTC ID +E + + GIR+I+ALRGD P S K Sbjct: 79 TCLHLTCTNMNRTLIDEALEETKAL-------GIRNILALRGDPPRSEEYNIDGEDDSNK 131 Query: 128 PEMYASDLVTLL-KEVAD-FDISVAAYPE-----VHPEAKSAQADLLNLKRKVDAGANRA 180 +A DLV + K+ D F I VA YPE HPE + DL L K AGA+ Sbjct: 132 DFSHAVDLVRYIRKKYGDYFCIGVAGYPEGHADESHPEVQDPLKDLPYLIEKTQAGADFI 191 Query: 181 ITQFFFDVESYLRFRD--RCVSAGI--DVEIIPGILPVSNFKQAKKFADMTNVRIPAWMA 236 +TQ +D+E+Y ++ D R +G + IIPG++P+ ++ + +++ +IP + Sbjct: 192 MTQLTYDIEAYRKYEDLLRNHESGTFKTIPIIPGLMPIQSYHTLTRVTKLSHAKIPPEIL 251 Query: 237 QMFDGLDDDAETRKLVGANIAMDMV---KILSREGVKDFHFYTLN 278 + D E K VG +I ++V K +S G + FHFYTLN Sbjct: 252 AKVEACKADDEVVKRVGVDIVSELVEGIKKISTPGHRGFHFYTLN 296 >UniRef50_C3PE90 Methylenetetrahydrofolate reductase n=8 Tax=Corynebacterium RepID=C3PE90_CORA7 Length = 307 Score = 130 bits (326), Expect = 7e-29, Method: Compositional matrix adjust. Identities = 85/285 (29%), Positives = 135/285 (47%), Gaps = 19/285 (6%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 +SFE PPR + + L++ P +++VT SG + T + I+ I T + Sbjct: 27 LSFEVIPPRHDADAAKIDRLLATLAAYNPDYIAVTSSQRSGWLEGTAAFIEKISRDTAMR 86 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY---ASDLVTLLKE 141 HL C T +EL + G+R ++ALRGDLP G G PE + A LV L++ Sbjct: 87 PLAHLACTAGTEEELVGWIDTLVDAGVRGLLALRGDLPEG-GMPEGHLPHADSLVRLIRR 145 Query: 142 ----------VADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESY 191 + VA YP H E+ + D+ L K GA+ AITQ FFD E Y Sbjct: 146 WESDRVARLAAGRLAVGVACYPNGHAESATPDEDIDVLLAKQRLGADFAITQLFFDAEDY 205 Query: 192 LRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGL--DDDAETR 249 +RF R AG+ + +IPGI+P+++ + ++ ++ + P ++ D L E Sbjct: 206 VRFAQRARLAGVRIPLIPGIMPMTSRARVERMCQLSGLAGP---TKVLDQLAAATSPEEE 262 Query: 250 KLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRP 294 K +G I + K + G H YT N +++ + + +GV P Sbjct: 263 KEIGMQITASLAKSVMNAGADGLHIYTHNNPDITTDLLNRIGVTP 307 >UniRef50_B2A780 Methylenetetrahydrofolate reductase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A780_NATTJ Length = 305 Score = 128 bits (322), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 88/282 (31%), Positives = 150/282 (53%), Gaps = 18/282 (6%) Query: 16 LAEVQGQIN---VSFEFFPPRTSEMEQ-----TLWNSIDRLSSLKPKFVSVTYGANSGER 67 ++E+ Q N VSFE FPP+ + + +L +ID L+ LKP F+SVTYGA Sbjct: 3 ISEIFSQSNGPVVSFEIFPPKRKKNQSKEDFDSLLKTIDNLARLKPDFISVTYGAGGTNS 62 Query: 68 DRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK 127 D + I + +K++ G+ + PH T I +E+ + +N G +I+ALRGDLP K Sbjct: 63 DGSLEISEYVKNK-GITSLPHFTSIGYPVEEINSYLGTIYNKGFENILALRGDLPKSPSK 121 Query: 128 PEM------YASDLVTLL-KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRA 180 ++ +A+DL+ ++ ++ +F I AAYPE H E+ A D+ +K K G Sbjct: 122 ADLVWRDFLHATDLIKVISRDFPNFCIGGAAYPEGHQESSYAGQDIEIMKIKEKMGVKFF 181 Query: 181 ITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFD 240 +TQ FF+ +++ +F + + G++ + G++P+ + K K +++ V++P + + Sbjct: 182 LTQLFFNNDNFFKFMENVRNNGVESPVSAGVMPLISPKYVDKIIELSGVKLPKELENALE 241 Query: 241 GL-DDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAE 281 DD+ E RK + + V L GV H YT+NR E Sbjct: 242 NYRDDEVEFRKR-SLDYCVRQVNDLFERGVDGVHLYTMNRHE 282 >UniRef50_Q03V90 Methylenetetrahydrofolate reductase n=2 Tax=Leuconostoc mesenteroides RepID=Q03V90_LEUMM Length = 297 Score = 128 bits (322), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 82/263 (31%), Positives = 126/263 (47%), Gaps = 11/263 (4%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPK-----FVSVTYGANSG-ERDRTHSIIKGIK 78 +SFE FPP+T + L+ + L + PK ++SVTYGA G RT I + I+ Sbjct: 16 LSFEIFPPKTEDGLHALYKT---LQEVNPKETGVDYISVTYGAGGGSNHKRTKEIAEYIE 72 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY--ASDLV 136 G+ A +LT I+ TP L+ G+ +I ALRGD P E Y A DL+ Sbjct: 73 RNCGITALHNLTGINQTPSSLKGNLEKISVAGVENIFALRGDTPTKDYVNEYYPFAKDLI 132 Query: 137 TLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRD 196 +K+ FDI A YPE H + + + +K KV +G I+Q FFD + ++ Sbjct: 133 KEIKKDGRFDIGAAIYPEGHVDNPTTGISVTGVKEKVISGTEFLISQLFFDNGVFYNMQE 192 Query: 197 RCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANI 256 I V + GILP+ + Q ++ M +PA +A++ +D E + G Sbjct: 193 ALKENYIKVPVSAGILPIISRAQVERITYMIGSSLPARLAKIVHKYEDQPEALQQAGIEY 252 Query: 257 AMDMVKILSREGVKDFHFYTLNR 279 A++ + L GV H Y +N+ Sbjct: 253 ALEQIHDLLDHGVDGIHLYAMNQ 275 >UniRef50_D0JBB4 Methylenetetrahydrofolate reductase n=31 Tax=Bacteria RepID=D0JBB4_BLASB Length = 320 Score = 128 bits (321), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 93/306 (30%), Positives = 135/306 (44%), Gaps = 43/306 (14%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANS----------------GERDR 69 SFE PP + +++++D L P F+ VTY R Sbjct: 16 SFEILPPLRGHDIKDIFSTLDPLMEFNPPFIDVTYHREEFIYVEKENGLLQRRKISRRPG 75 Query: 70 THSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP- 128 T I I ++ G++A PHL C D GI +++ LRGD P S K Sbjct: 76 TVGICAAIMNKYGVDAVPHLICGGFNKQMTENALIDLNFLGIDNVLVLRGD-PLKSEKDF 134 Query: 129 ------EMYASDLVTLLKEVA------------------DFDISVAAYPEVHPEAKSAQA 164 YA +LV +K++ DF I VA YPE H EA + ++ Sbjct: 135 IAKKDGHKYAVELVEQVKDLNRGKYLDKTFVERKESPLFDFCIGVAGYPEKHLEAPNIES 194 Query: 165 DLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA 224 DL LK+KV++GA+ +TQ FFD + Y F +C S GI V IIPGI P+S+ KQ Sbjct: 195 DLFFLKKKVESGADYIVTQMFFDNKKYFSFVKKCRSEGISVPIIPGIKPISSKKQLNSLP 254 Query: 225 DMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSY 284 + IP + + + D + +G A+ K L GV+ H+YT++R E Y Sbjct: 255 SHFYLNIPNELVKEVEKA-KDKKIISHIGIEWAIHQSKELKNFGVEVIHYYTMDRPENIY 313 Query: 285 AICHTL 290 I + Sbjct: 314 KIIQAI 319 >UniRef50_Q4Q0B9 Methylenetetrahydrofolate reductase n=3 Tax=Leishmania RepID=Q4Q0B9_LEIMA Length = 309 Score = 127 bits (320), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 85/295 (28%), Positives = 140/295 (47%), Gaps = 30/295 (10%) Query: 17 AEVQGQINVSFEFFPPRTSEMEQTLWNS-IDRLSSLKPKFVSVTYGANSGERDRTHSIIK 75 AE + N S+E +PPR+ + E+ + + P F+ +T+GA T + K Sbjct: 11 AEDASKWNTSYELYPPRSEKAEEDMMKVLVPNFMHQSPVFLDLTWGAGGRTSGTTMRLCK 70 Query: 76 GIKDRTGLEAAP------HLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG--- 126 ++ A P H+TC + ++ +GIR+I+ALRGD P G Sbjct: 71 DLQ-----HAHPDTPINMHITCTNTPKGLIKETLEFAKTHGIRNILALRGDPPSGEEFQV 125 Query: 127 KPEMYAS--DLVTLLKEVAD--FDISVAAYPEVHPE---------AKSAQADLLNLKRKV 173 P+ +A DLV +++ F +SVA YPE HP + Q +L LK KV Sbjct: 126 DPDGFACARDLVRYIRDTYGDYFCVSVAGYPEGHPSRIAENGTISHEDHQKELEYLKEKV 185 Query: 174 DAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPA 233 DAGA+ ITQ F+D Y++F RC GI V I+ G+LP++ + + + +P+ Sbjct: 186 DAGASFIITQLFYDASLYVKFVKRCREVGITVPILAGLLPITTYAGFVRMVSLCKTSVPS 245 Query: 234 WMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGV--KDFHFYTLNRAEMSYAI 286 + + + L ++ + K G + M++ + G+ HFYTLN + + I Sbjct: 246 DVKKRVEELKENPDGLKEYGVEQCVQMIECIRASGLDYHHLHFYTLNNSAQIFKI 300 >UniRef50_D0YUL0 Methylenetetrahydrofolate reductase n=1 Tax=Mobiluncus mulieris 28-1 RepID=D0YUL0_9ACTO Length = 350 Score = 126 bits (317), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 98/290 (33%), Positives = 141/290 (48%), Gaps = 18/290 (6%) Query: 4 FHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN 63 F + R A +S + VSFE +PPR + W IDRL P +VSVT+G + Sbjct: 25 FTSVSRGANPKSSRNPTRPVRVSFELYPPRNPDPFSQAWAGIDRLLDAHPDYVSVTFGTS 84 Query: 64 SGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP 123 + + S++ R G HLTC+ T EL T + + G+R +ALRGD P Sbjct: 85 NSTSASSQSVLAHALQRLGRPVLAHLTCVGKTRTELSTTITEMLDIGVRDFLALRGDNPK 144 Query: 124 GSGKPE------MYASDLVTLLKEVA--------DFDISVAAYPEVHPEAKSAQADLLNL 169 GS E AS LVTLL+EVA I+VAAYP A++ + L Sbjct: 145 GSVNWEPAPGEFSRASQLVTLLREVAAEYLGDARAISIAVAAYPAGTVSARTNA--VAAL 202 Query: 170 KRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNV 229 K AGA+ AITQ F++ + Y D G+ + IIPGI+P ++ + ++ +T V Sbjct: 203 AEKQSAGADFAITQVFYNADDYGALLDSATYQGVSIPIIPGIIPFTDAARLQRLEGLTGV 262 Query: 230 RIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNR 279 +P+ + + + D E R L G + +D V L + G HFYT NR Sbjct: 263 SVPSRLQAISE--ISDPEERFLEGLSATLDFVNDLIQAGAPGLHFYTFNR 310 >UniRef50_C2KSD1 Methylenetetrahydrofolate reductase n=2 Tax=Mobiluncus RepID=C2KSD1_9ACTO Length = 307 Score = 125 bits (315), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 94/271 (34%), Positives = 135/271 (49%), Gaps = 18/271 (6%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 + VSFE +PPR + W IDRL P +VSVT+G ++ + S++ R G Sbjct: 1 MRVSFELYPPRNPDPFSQAWAGIDRLLDAHPDYVSVTFGTSNSTSASSQSVLAHALQRLG 60 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE------MYASDLV 136 HLTC+ T EL T + + G+R +ALRGD P GS E AS LV Sbjct: 61 RPVLAHLTCVGKTRAELSTTITEMLDIGVRDFLALRGDNPKGSVNWEPAPGEFSRASQLV 120 Query: 137 TLLKEVA--------DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDV 188 TLL+EVA I+VAAYP A++ + L K AGA+ AITQ F++ Sbjct: 121 TLLREVAAEYLGDARAISIAVAAYPAGTVSARTNA--VAALAEKQSAGADFAITQVFYNA 178 Query: 189 ESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAET 248 + Y D G+ + IIPGI+P ++ + ++ +T V +P+ + + + D E Sbjct: 179 DDYGALLDSATYQGVSIPIIPGIIPFTDAARLQRLEGLTGVSVPSRLQAISE--ISDPEE 236 Query: 249 RKLVGANIAMDMVKILSREGVKDFHFYTLNR 279 R L G + +D V L + G HFYT NR Sbjct: 237 RFLEGLSATLDFVNDLIQAGAPGLHFYTFNR 267 >UniRef50_A2QUJ5 Methylenetetrahydrofolate reductase n=16 Tax=Leotiomyceta RepID=A2QUJ5_ASPNC Length = 699 Score = 125 bits (314), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 94/282 (33%), Positives = 148/282 (52%), Gaps = 33/282 (11%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLS-SLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 S EFFPP+T L ++R++ +L+P FV+VT+GA R+ + + + + L Sbjct: 19 SLEFFPPKTKMGFANLQARLERMAQALRPLFVTVTWGAGGSTAARSLELAEICQRQLQLT 78 Query: 85 AAPHLTCID---ATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM----------- 130 HLTC + A DE A+ GIR+I+ALRGD PP S + M Sbjct: 79 TCLHLTCTNMSRALVDEALEEAKVL---GIRNILALRGD-PPRSEEYNMHGEDDSNKDFT 134 Query: 131 YASDLVTLL-KEVAD-FDISVAAYPEVHP-----EAKSAQADLLNLKRKVDAGANRAITQ 183 +A DLV + K+ D F I VAAYPE HP + + DL L K AGA+ +TQ Sbjct: 135 FAVDLVRYIRKQYGDYFCIGVAAYPEGHPADNFQDGQDPARDLPFLIEKTQAGADFIMTQ 194 Query: 184 FFFDVESYLRFRD--RCVSAGI--DVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMF 239 +D+E+Y +F R +G+ + I+PG++P+ ++K + +++V+IP + Sbjct: 195 LTYDLEAYTKFETMLRNHESGVFKTIPIVPGLMPIHSYKILTRVTKLSHVKIPPHVLSKL 254 Query: 240 DGLDDDAETRKLVGANIAMDMV---KILSREGVKDFHFYTLN 278 + + D + K +G +I D+V + L G++ FHFYTLN Sbjct: 255 EEVKHDDDAVKRIGVDIISDLVHGIRDLVSPGLRGFHFYTLN 296 >UniRef50_B7AVK8 Methylenetetrahydrofolate reductase n=1 Tax=Bacteroides pectinophilus ATCC 43243 RepID=B7AVK8_9BACE Length = 218 Score = 125 bits (314), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 71/205 (34%), Positives = 111/205 (54%), Gaps = 5/205 (2%) Query: 48 LSSLKPKFVSVTYGAN-SGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDY 106 + +P ++SVT+GA S ++T + + IK++ +E HLTC+ E+ R+ Sbjct: 1 MCDCRPDYISVTFGAGGSSNNNKTIQLARKIKEKYHVEPVVHLTCLCYNRAEIDEFVREL 60 Query: 107 WNNGIRHIVALRGDLPPGSGKPE--MYASDLVTLLKEVAD--FDISVAAYPEVHPEAKSA 162 GI +I+ALRGD P E +ASDL+ L+ F I+ A YP+VHPE + Sbjct: 61 TAEGIENILALRGDRNPDVPAKEDFAHASDLIKYLRATTGDRFCIAGACYPDVHPETGNR 120 Query: 163 QADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKK 222 D+ NLK K DAGA+ I+Q FFD +++L+F C A I+V I+PGI+P N Q ++ Sbjct: 121 VDDINNLKIKTDAGADILISQLFFDNDTFLQFVSDCRRARIEVPIVPGIMPCINAAQIQR 180 Query: 223 FADMTNVRIPAWMAQMFDGLDDDAE 247 M + P ++ D+ + Sbjct: 181 MVTMCGAKFPERFRKLIRKYGDNKD 205 >UniRef50_A6W6I5 Methylenetetrahydrofolate reductase n=1 Tax=Kineococcus radiotolerans SRS30216 RepID=A6W6I5_KINRD Length = 317 Score = 125 bits (314), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 83/292 (28%), Positives = 139/292 (47%), Gaps = 30/292 (10%) Query: 12 LNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTH 71 L +A G+ +SFE FPPR+ + LW + L + +P FVSVT+GA R + Sbjct: 3 LAPLVAGAAGRPVLSFELFPPRSESAREGLWRKLSDLLAARPDFVSVTFGAAGATRGPSR 62 Query: 72 SIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG----SGK 127 ++ + T + A HLTC+ ++ E+ +A ++ + G+R+++ALRGD P G + Sbjct: 63 DLLAHVLRTTAVPAMAHLTCVGSSRREVVDLASEFLDAGVRNVLALRGDPPAGDAGWTPH 122 Query: 128 PEMYAS--DLVTLLK----------------EVADFDISVAAYPEVHPEAKSAQADLLNL 169 P+ A+ DLV LL+ + ++VAA+P + + +L L Sbjct: 123 PDGVATARDLVELLQVADRRRAALRGARVPVDEGPLSLAVAAFP------RGGEGELAAL 176 Query: 170 KRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNV 229 + K DAGA+ A+ Q F Y F R +AG+ + ++PG+ ++ + ++T V Sbjct: 177 RAKQDAGADFAVCQVTFSAGEYAAFVRRARAAGVRIPLLPGVAVTDCTRRLGRIGELTGV 236 Query: 230 RIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAE 281 +P + D DDA R+ + + L G H YT N AE Sbjct: 237 PVPVPLLAALD--TDDAPRRRRAATAFTAGLARGLLDAGAPGVHLYTFNAAE 286 >UniRef50_C8V780 Methylenetetrahydrofolate reductase n=17 Tax=Leotiomyceta RepID=C8V780_EMENI Length = 684 Score = 124 bits (311), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 92/286 (32%), Positives = 148/286 (51%), Gaps = 41/286 (14%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLS-SLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 S EFFPP+T L ++R++ +L+P FV+VT+GA R+ + + + + L Sbjct: 19 SLEFFPPKTQMGFANLQARLERMAQALRPLFVTVTWGAGGSTAARSLELAEICQRQLQLT 78 Query: 85 AAPHLTC-------IDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM------- 130 HLTC +D +E + + GIR+I+ALRGD PP S + M Sbjct: 79 TCLHLTCTNMSRALVDQALEEAKVL-------GIRNILALRGD-PPRSEEYNMHGEDDSN 130 Query: 131 ----YASDLVTLL-KEVAD-FDISVAAYPEVHP-----EAKSAQADLLNLKRKVDAGANR 179 +A DLV + K+ D F + VAAYPE HP + + + DL L K AGA+ Sbjct: 131 KDFTFAVDLVRYIRKKYGDYFCVGVAAYPEGHPADSFQDIQDPKVDLPWLVEKTQAGADF 190 Query: 180 AITQFFFDVESYLRFRD--RCVSAGI--DVEIIPGILPVSNFKQAKKFADMTNVRIPAWM 235 +TQ +D+++Y F + R +G + IIPG++P+ ++K + +++V+IP + Sbjct: 191 IMTQLTYDIDAYTEFENLLRNHESGTFKTIPIIPGLMPIHSYKILTRVTKLSHVKIPPPI 250 Query: 236 AQMFDGLDDDAETRKLVGANIAMDMV---KILSREGVKDFHFYTLN 278 D + D + K +G +I ++V K L G++ FHFYTLN Sbjct: 251 LAKLDEVKHDDDAVKRLGVDILAELVDGMKKLPTPGLRGFHFYTLN 296 >UniRef50_C4R2Q6 Methylenetetrahydrofolate reductase n=6 Tax=Saccharomycetaceae RepID=C4R2Q6_PICPG Length = 603 Score = 124 bits (310), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 84/270 (31%), Positives = 135/270 (50%), Gaps = 17/270 (6%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEA 85 SFEFF P+T++ Q L++ +DR+ +L P+F+ +T+ A + T +I + GLE Sbjct: 21 SFEFFTPKTAQGVQNLYDRMDRMYNLSPQFIDITWNAGGRSSNLTCEMINTAQTVLGLET 80 Query: 86 APHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM----YASDLVTLLKE 141 HLTC + T + + + +++G ++I+ALRGD PP G YA DL+ +KE Sbjct: 81 CMHLTCTNMTLEVIDEALKSAYDSGCQNILALRGD-PPLDGSESTGCFRYAKDLIKHIKE 139 Query: 142 VADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSA 201 HP+ + LK K DAG + ITQ F+DVE ++ + + Sbjct: 140 KYG-----------HPDEPDVDRLIEILKEKQDAGGDFMITQMFYDVEQFITWCKKVRDY 188 Query: 202 GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMV 261 GI + IIPGI+P+S + + A + +P+W + D DD + +G + DM Sbjct: 189 GITIPIIPGIMPISTYASFSRRAKWCQINVPSWFQKQLDASKDDDSEVRCLGTQLVADMC 248 Query: 262 KILSREG-VKDFHFYTLNRAEMSYAICHTL 290 L G V HFYT+N + + + L Sbjct: 249 LKLVESGYVNHLHFYTMNLEKSTIMVLEKL 278 >UniRef50_A9BEZ6 Methylenetetrahydrofolate reductase n=2 Tax=Thermotogaceae RepID=A9BEZ6_PETMO Length = 315 Score = 122 bits (306), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 85/290 (29%), Positives = 131/290 (45%), Gaps = 33/290 (11%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN---------------SGERDR 69 +SFE PP E +++N +D L PK+++VT AN +R Sbjct: 15 LSFEIIPPNVGESIDSIFNVVDNLIEFSPKYINVTKHANEIDYVEENGKIMKIIQKKRPG 74 Query: 70 THSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE 129 T + IK R +E PHL C +L I D I +I +RGD + K Sbjct: 75 TVGVSASIKHRYNIEVVPHLICTGFNKYQLEDILIDLNYLRIENIFVVRGDKKRYTWKET 134 Query: 130 ---MYASDLVTLLKEV--------------ADFDISVAAYPEVHPEAKSAQADLLNLKRK 172 +AS LV + + +F + VA YPE H E+ + + DL LK K Sbjct: 135 DEYEHASQLVEQIANMNRGIYTFPTKEHNSTNFCVGVAGYPEKHFESPNFEKDLDYLKLK 194 Query: 173 VDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIP 232 VD GA ITQ FFD+E Y F ++ GI+V IIPGI P+ + K +V IP Sbjct: 195 VDMGATFIITQMFFDIEYYKNFVNKVRDLGIEVPIIPGIKPLGSKKTLYNIPKTFHVNIP 254 Query: 233 AWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEM 282 + + F+ ++ ++G A+ +++ L GV H +T+ + ++ Sbjct: 255 KSIVEEFENA-KSSQDEYIIGVRHAIKLIEQLLELGVPGVHLFTMGKGKI 303 >UniRef50_C7M2P8 Methylenetetrahydrofolate reductase n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7M2P8_ACIFD Length = 284 Score = 120 bits (300), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 81/268 (30%), Positives = 130/268 (48%), Gaps = 12/268 (4%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 G+ S E +P RTS+ E L ++D L SL P FVSVTYGA R + ++I+ + Sbjct: 9 GERVCSVELWPARTSDQEHRLTATLDVLRSLPPAFVSVTYGAFGSSRHESLALIERVLA- 67 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM-----YASDL 135 G HL +P++L + G ++ALRGD P +A +L Sbjct: 68 DGHRVLAHLAVAGHSPEQLVALLTHVERLGADGVLALRGDPPLDDPDDRARFVGRHALEL 127 Query: 136 VTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFR 195 V L ++ + VA +P HPEA+S + DL + K+ A A+ ITQF+F+ + R R Sbjct: 128 VELARQHTQLSVGVALHPSGHPEARSLEDDLDHQAAKL-ARADFGITQFYFEAAALTRLR 186 Query: 196 DRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGAN 255 G+ +IPG+L + +Q + +M VR+P + + +G D A R +VG Sbjct: 187 GALRGRGVTRPVIPGLLVPRSPRQLLRMGEMAAVRVPRELVEALEGPDGPARARTVVG-- 244 Query: 256 IAMDMVKILSREGVKDFHFYTLNRAEMS 283 ++ EG H +++N+ E + Sbjct: 245 ---ELASAALEEGSPGVHLFSMNQPETT 269 >UniRef50_Q4P1E8 Methylenetetrahydrofolate reductase n=1 Tax=Ustilago maydis RepID=Q4P1E8_USTMA Length = 684 Score = 119 bits (297), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 94/319 (29%), Positives = 147/319 (46%), Gaps = 52/319 (16%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLS-SLKPKFVSVTYGA---------------------- 62 SFEFFPP+TS+ L+N I R+ +L+P ++ VT+GA Sbjct: 41 SFEFFPPKTSQGLANLYNRIARMHVNLEPSWIHVTWGAGGTTGGKSLELAGRIQKGKLDP 100 Query: 63 ------------NSGERDRTHSIIKGIKDRTGLEAAP-----HLTCIDATPDELRTIARD 105 SG + ++ KG ++ A P HLTC + L Sbjct: 101 DVELVQTEINHIGSGTQQHIENV-KGGQEWEQERADPCDVCLHLTCTNVEKSSLDQTLDT 159 Query: 106 YWNNGIRHIVALRGDLPPG------SGKPEMYASDLVTLLKEVAD--FDISVAAYPEVHP 157 GI++I+ALRGD P G + K +A+DLV +++ F I VA YPE H Sbjct: 160 AKRLGIKNILALRGDPPRGEEYWIAADKRFQHATDLVRYIRQRHGNYFCIGVAGYPEGHA 219 Query: 158 EA--KSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVS 215 + + DL LK K DAGA ITQ F+DV+ +L + C GI + I+PGI+P+ Sbjct: 220 DYVDRDVNRDLRYLKDKQDAGAQYIITQLFYDVDRFLEWYRDCREIGITIPILPGIMPIQ 279 Query: 216 NFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMV-KILSREGVKDFHF 274 N+ ++ ++ V++P + + + D K G ++++ MV +I V+ FH Sbjct: 280 NYSSFRRMTNLCKVQVPQLILDALEPIKSDDAAVKEYGVSLSIHMVGRIFLETDVRGFHL 339 Query: 275 YTLNRAEMSYAICHTLGVR 293 +LN + I LG + Sbjct: 340 CSLNLEKSIERILEGLGWK 358 >UniRef50_Q6CEM7 Methylenetetrahydrofolate reductase n=1 Tax=Yarrowia lipolytica RepID=Q6CEM7_YARLI Length = 625 Score = 117 bits (294), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 84/273 (30%), Positives = 136/273 (49%), Gaps = 21/273 (7%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEA 85 S EFFPP+T + R+++LKP F+++T+GA ++ I + GL+ Sbjct: 19 SLEFFPPKTQNGMANFRARLARMAALKPLFITITWGAGGSTAKKSLDIASECQS-MGLDV 77 Query: 86 APHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS-----GKPEM-YASDLVTLL 139 HLTC + P + GI +I+ALRGD P G PE +A+DLV + Sbjct: 78 CLHLTCTNMDPALIDQALEAASKAGICNILALRGDPPRGEEYWQPASPEFQHAADLVKYI 137 Query: 140 KEV--ADFDISVAAYPEVHPEAKSA-----QADLLNLKRKVDAGANRAITQFFFDVESYL 192 K+ F + VA YPE H + A DL LK KV+AGA+ ITQ F+D +L Sbjct: 138 KKKHGNKFCVGVAGYPEGHVDGSDASHQDFHHDLPYLKEKVEAGADFIITQMFYDDNKFL 197 Query: 193 RFRD--RCVSAGI-DVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETR 249 + R S + ++ IIPG++P++ + + A +++ +P + + + + Sbjct: 198 EYNKAVREFSPLLKNITIIPGLMPINTYTSFVRAARLSHASVPPAILDRIQAVPTGNDQQ 257 Query: 250 -KLVGANIAMDMVKIL---SREGVKDFHFYTLN 278 K +G + D+V + + + V+ FHFYTLN Sbjct: 258 VKDIGVEVVSDIVNDVYTKTNKTVRGFHFYTLN 290 >UniRef50_UPI00015B5A5C PREDICTED: hypothetical protein n=1 Tax=Nasonia vitripennis RepID=UPI00015B5A5C Length = 326 Score = 117 bits (294), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 85/266 (31%), Positives = 133/266 (50%), Gaps = 22/266 (8%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY--GANSGERDRTHSIIKGIKDRTG 82 S+E FP + + Q + +P F ++T+ G +GE +R S+ Sbjct: 49 CSYELFPTKCHGVYQGFFRDT---QICEPLFYALTWHEGWATGE-ERFPSL-------KS 97 Query: 83 LEAAPHLTCIDATPDELR-----TIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVT 137 E P T + T L+ I GI +I AL+GD G +ASDLV Sbjct: 98 AEVFPRNTLLHCTAKGLKKTDAEMILTRALELGIANIFALQGDSGSDDGD-FDHASDLVK 156 Query: 138 LLKEV--ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFR 195 ++E F I VA YPE+HP + S + D+ LK KVDAGA+ +TQFFF+ + +++F Sbjct: 157 FIRERYGQQFSICVAGYPEMHPHSPSKELDIFYLKAKVDAGADFILTQFFFESQLFIKFV 216 Query: 196 DRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGAN 255 + C GI V IIPGI P ++ K K ++ + IP W+ + ++DD E + G + Sbjct: 217 NDCREVGISVPIIPGIYPFTDVKLLGKMIEICHTNIPDWIQEELRHIEDDDEAVRKFGID 276 Query: 256 IAMDMVK-ILSREGVKDFHFYTLNRA 280 +++ ++K I +H YTLNR+ Sbjct: 277 LSVKLIKEIRESAHFCGYHVYTLNRS 302 >UniRef50_D1PME0 Methylenetetrahydrofolate reductase n=1 Tax=Subdoligranulum variabile DSM 15176 RepID=D1PME0_9FIRM Length = 287 Score = 116 bits (290), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 76/267 (28%), Positives = 126/267 (47%), Gaps = 8/267 (2%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDR-THSIIKGIKDRTGLE 84 S E FPP+ + + L ++ + L+P F+SVT+GA T + I++ G+ Sbjct: 15 SIECFPPKQTTQMEKLRGTLFAMKDLQPDFISVTFGAGGSAGGVSTVEVADLIQNELGIP 74 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE----MYASDLVTLLK 140 A HL C+ I + G+ ++ALRGD P +PE +A DL +K Sbjct: 75 ALAHLICMGNDKTSAAKILDELEQVGVHDVLALRGDRTPN--RPESPDFAHACDLTAFIK 132 Query: 141 EVA-DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199 F + A YPE HPEA++ + D+ NL K AGA +TQ FFD + RF + Sbjct: 133 SYKPGFSVHGACYPEGHPEAENLRQDVENLCTKQAAGAEHLVTQLFFDNMHFYRFLNLAR 192 Query: 200 SAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMD 259 AGI + + G++P+ Q ++ +++ +P+ +M DD G + A+ Sbjct: 193 RAGITLPVSAGVMPIVKRSQIERTVALSSASLPSDFTRMISRWQDDPAALYEAGIDYAVR 252 Query: 260 MVKILSREGVKDFHFYTLNRAEMSYAI 286 ++ L G H Y +N A ++ + Sbjct: 253 QLRDLIEGGADGVHLYAMNDAAVAKKV 279 >UniRef50_Q2S0T1 Methylenetetrahydrofolate reductase n=4 Tax=cellular organisms RepID=Q2S0T1_SALRD Length = 319 Score = 115 bits (288), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 80/293 (27%), Positives = 127/293 (43%), Gaps = 38/293 (12%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE----------------RD 68 +S+E PP+ + ++ L +P F+ VT + E R Sbjct: 15 ISYEIIPPKRGGSADQILGVVEELMPYEPPFIDVTSHSAEVEYKQKDDGTWTRCVKRKRP 74 Query: 69 RTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD------LP 122 T + I+ R ++ PH+ C T +E + G+ +++A+RGD Sbjct: 75 GTIGLCAAIEARFDIDTVPHILCKGFTREETEDALIELNYLGVENVLAIRGDDNGYEKSI 134 Query: 123 PGSGKPEMYASDLVTLLK--------------EVADFDISVAAYPEVHPEAKSAQADLLN 168 G+ YA DLV ++ E DF + V YPE H EA + D++ Sbjct: 135 SGNRSRNEYAVDLVRQIQDMNEGTYLEDLMDAEPTDFCVGVGGYPETHFEAPNLAWDIMR 194 Query: 169 LKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTN 228 LK +VDAGA+ +TQ FFD E + F D+C GI+V I+PG+ + + + + Sbjct: 195 LKEQVDAGADYIVTQMFFDNEYFFNFVDKCREVGIEVPIVPGLKILKRKRHLRLLPKYFH 254 Query: 229 VRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAE 281 IP +A D D D R +G N A+ + L GV HFY ++ A+ Sbjct: 255 TEIPEELAAEVDAADPDDVER--IGVNWAIRQARELMEAGVPGIHFYIMSSAD 305 >UniRef50_A8QAM7 Methylenetetrahydrofolate reductase n=1 Tax=Malassezia globosa CBS 7966 RepID=A8QAM7_MALGO Length = 589 Score = 114 bits (285), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 100/305 (32%), Positives = 155/305 (50%), Gaps = 44/305 (14%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLS-SLKPKFVSVTYGANSGERDRTHSII----KGIKD- 79 S EFFPPRT+ L + R+S +L+P +V VT+G RD + + KG+ D Sbjct: 27 SLEFFPPRTALGLANLCARVARMSEALQPGWVHVTWGTGGSTRDASMELAARVQKGVYDP 86 Query: 80 -----------RTGLEAAPHLTC-------IDATPDELRTIARDYWNNGIRHIVALRGDL 121 + + HLTC +DAT DE R I GIR+I+ALRGD Sbjct: 87 LEDYTNVKERRKGACDVCLHLTCTNVERAYLDATLDEARQI-------GIRNILALRGD- 138 Query: 122 PPGSGKPEMY-------ASDLVTLLKEVAD--FDISVAAYPEVHPEAKSA--QADLLNLK 170 PP S + + A+DLV ++E F I VA YPE + + D+ LK Sbjct: 139 PPRSDEYWVATDQRLQNATDLVRYIRERHGDYFCIGVAGYPEGLKQGIDCDMRHDIKVLK 198 Query: 171 RKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVR 230 K +AGA+ +TQ F+DV++ +R+ C +AGI + IIPGI+P+ N+ ++ A++ V Sbjct: 199 AKQEAGAHFIVTQLFYDVDALVRWTKECRAAGITIPIIPGIMPIQNYTMFRRMANLCGVH 258 Query: 231 IPAWMAQMFDGLDDDAETRKLVGANIAMDMVK-ILSREGVKDFHFYTLNRAEMSYAICHT 289 P + + + + D K G ++++DM+K I + G++ FH YTLN + + + Sbjct: 259 TPEDVLEQLEPIKMDDAKVKEHGIHLSIDMIKSIREQTGIRAFHLYTLNLEKSATCVIKV 318 Query: 290 LGVRP 294 L P Sbjct: 319 LADVP 323 >UniRef50_B5Y6J3 Methylenetetrahydrofolate reductase n=2 Tax=Bacteria RepID=B5Y6J3_COPPD Length = 318 Score = 113 bits (282), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 87/311 (27%), Positives = 138/311 (44%), Gaps = 43/311 (13%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKP-KFVSVTYGANSG------------- 65 QG+I +S E PP + ++ ++D L + P F++VT A Sbjct: 9 QGRI-ISIEVLPPNRGHSAEDIFKAVDELITDYPISFINVTRHAAETTYVELEDGIIVKV 67 Query: 66 ---ERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP 122 +R T + + R ++ PH+ C EL + D + G++++ A+RG+ Sbjct: 68 PKVKRPGTVGLTAALMKRYSVDVVPHVLCRGMNKFELEDLLIDLYLIGVQNVFAIRGEYE 127 Query: 123 PGSGKPEM--------YASDLVTLLKEV--------------ADFDISVAAYPEVHPEAK 160 G+ + YA DLV + + DF I VA YPE H EA Sbjct: 128 NAEGESKQENNKDYHTYAVDLVQQIAHMNKGHYLYQKESTMSTDFCIGVAGYPEKHFEAP 187 Query: 161 SAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQA 220 + + D+ +LK KV+AGAN ITQ FD + Y F +R S GI+V IIPGI PV + K Sbjct: 188 NLEEDMKHLKEKVEAGANYIITQMVFDFDVYKDFVERARSIGINVPIIPGIKPVVSLKSI 247 Query: 221 KKFADMTNVRIP-AWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNR 279 V IP A++ +M + E VG +V+ L G H +T+ + Sbjct: 248 YSIPRKFFVNIPHAFLEKMQEAKSSKEEFE--VGTAFMASLVEKLLSWGAPGLHLFTMGK 305 Query: 280 AEMSYAICHTL 290 ++ + A+ + Sbjct: 306 SKSAKALLQAV 316 >UniRef50_C0W5C3 Methylenetetrahydrofolate reductase n=1 Tax=Actinomyces urogenitalis DSM 15434 RepID=C0W5C3_9ACTO Length = 384 Score = 109 bits (272), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 79/286 (27%), Positives = 128/286 (44%), Gaps = 32/286 (11%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY-----------GANSGERDRTH- 71 ++S E FPPR W ++DRL + +P FVSVTY A +G R H Sbjct: 46 SLSLELFPPRPGRYASQTWGALDRLLAARPDFVSVTYRPRFITTAGGPTAAAGSPTRLHV 105 Query: 72 --------SIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP 123 ++ + + + HLTC+ + I R + + G+R +ALRGD P Sbjct: 106 VREHNPSEDVVAHVIATSRVPLMAHLTCLGYRKANVVEIVRLFLDMGVRRFLALRGDPPR 165 Query: 124 GSGKPEM-----YASDLVTLLKEV-ADFDISVAAYPEVHPEAKSAQADLLN----LKRKV 173 G ++ +A LV +++EV A++ A + +V A A D L K Sbjct: 166 GVAAEDVVGELRHADQLVRVIREVEAEYFDDGARHVQVAVAAYPAAVDYAREIGVLAAKQ 225 Query: 174 DAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPA 233 AGA+ AITQ F++ E YL G+ + I+PGI+P+++ ++ + D+T V +P Sbjct: 226 AAGADLAITQVFYESEDYLALARAASYCGVTMPILPGIIPLTDLRRLTRLEDLTGVSVPT 285 Query: 234 WMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNR 279 ++Q + G + + + L G H YT NR Sbjct: 286 RLSQTLT--SRQGASVMTAGIDATLQLAGDLIEGGAPGLHLYTFNR 329 >UniRef50_O74927 Methylenetetrahydrofolate reductase 2 n=2 Tax=Schizosaccharomyces RepID=MTHR2_SCHPO Length = 641 Score = 108 bits (270), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 95/284 (33%), Positives = 149/284 (52%), Gaps = 28/284 (9%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLS-SLKPKFVSVTYGANSGERDRTHSIIKGIK 78 G SFE+FPP+T+ + L + I R+S ++ P F SVT+G + + + K ++ Sbjct: 12 NGNAFYSFEYFPPKTTVGLENLSSRITRMSRNMMPLFSSVTWGTAGSTAEVSIYLAKMLE 71 Query: 79 DRTGLEAAPHLTCID---ATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE------ 129 + A HLTC + A D+ A++Y GIR+I+ALRGD P S E Sbjct: 72 QHHKIPACLHLTCTNVDKAIIDKALETAKEY---GIRNILALRGDPPLNSDHWEGKVSEF 128 Query: 130 MYASDLVTLLKEVAD--FDISVAAYPEVH-----PE-AKSAQADLLNLKRKVDAGANRAI 181 +A DLV ++E F I VAAYPE H PE +K D+ L KV+AGA+ I Sbjct: 129 EHAVDLVRYIREKYGDYFCIGVAAYPEGHVDSNVPELSKDPLRDIPFLIEKVEAGADFII 188 Query: 182 TQFFFDVESYLRF----RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQ 237 TQ F++ E++++F R+ +A ++ IIP I+P+ ++ K+ + +P+ + Q Sbjct: 189 TQIFYEPEAFIKFENFVRNHSSNALRNIPIIPAIMPIQSYGSLKRMTRLCGCSVPSSLMQ 248 Query: 238 MFDGLDDDAETRKLVGANIAMDMVKIL--SREG-VKDFHFYTLN 278 + D E K +G +DM+K + + +G V FHF TLN Sbjct: 249 RLNAAKPDDEAIKNIGVEHIVDMIKKIMDNVQGRVHGFHFCTLN 292 >UniRef50_A7TTE9 Methylenetetrahydrofolate reductase n=2 Tax=Saccharomycetaceae RepID=A7TTE9_VANPO Length = 612 Score = 107 bits (267), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 74/239 (30%), Positives = 107/239 (44%), Gaps = 28/239 (11%) Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM----------- 130 GLE HLTC + + + +G +I+ALRGD P G+P Sbjct: 53 GLETCMHLTCTNMSLAAIDAALEQAHASGCHNILALRGD--PPRGQPSTASSSESGSSGG 110 Query: 131 ------------YASDLVTLL--KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAG 176 +A+ LV + K F I VA YPE E + L +LK KV+ G Sbjct: 111 GNGSSDGDCNFKFAAQLVRYIRSKYGNHFAIGVAGYPEGDGEQADQRLLLQHLKEKVECG 170 Query: 177 ANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMA 236 A+ ITQ F+DV+++LR+ G+ V IIPGI+P+S + + VR+P Sbjct: 171 ADFIITQMFYDVDNFLRWVHGLREVGVTVPIIPGIMPISTYAAFLRRCSWCGVRVPDNFL 230 Query: 237 QMFDGLDDDAETRKLVGANIAMDMVKILSREG-VKDFHFYTLNRAEMSYAICHTLGVRP 294 Q + DD E + +G + +DM + L G V H YT+N I LG+ P Sbjct: 231 QRLAPVSDDDELVREIGTQLVVDMCRRLLESGVVSHLHLYTMNLERPPLVILERLGLLP 289 >UniRef50_A6L1E2 Methylenetetrahydrofolate reductase n=45 Tax=Bacteroidetes RepID=A6L1E2_BACV8 Length = 317 Score = 105 bits (263), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 76/297 (25%), Positives = 129/297 (43%), Gaps = 52/297 (17%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVT----------YGANSGERDR------ 69 SFE PP + L+ ++D L PK++++T G +R R Sbjct: 16 SFEILPPLKGTGIEKLYKTVDTLREFDPKYINITTHRSEYVYKELGNGLYQRTRQRRRPG 75 Query: 70 THSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD--------L 121 T ++ ++++ + PH+ C + ++ + D GI ++ LRGD + Sbjct: 76 TVAVAAALQNKYNITTVPHILCSGFSREDTEYVLLDLQFLGITDLLVLRGDKAKHESAFV 135 Query: 122 PPGSGKPEMYASDLVTLLKEVADFD------------------ISVAAYPEVHPEAKSAQ 163 P +G + + L +++ DF+ VA YPE H E+ + + Sbjct: 136 PENNG-----YNHAIELEEQINDFNKGVFVDGSPIKVTGTPFSYGVACYPEKHEESPNME 190 Query: 164 ADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF 223 D+ LK+K++AGA A+TQ F+D Y F +R GI+V IIPGI P Q Sbjct: 191 QDIYWLKKKIEAGAEYAVTQMFYDNRKYFEFVERVRKEGINVPIIPGIKPFRKLSQLNMI 250 Query: 224 ADMTNVRIPAWMA--QMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLN 278 + +P +A M D++AE+ +G + + L GV HFYT++ Sbjct: 251 PKTFKIDLPQELAGEAMKCQTDEEAES---LGIEWCIHQCRELIACGVPSIHFYTVS 304 >UniRef50_A8F6Y4 Methylenetetrahydrofolate reductase n=2 Tax=Thermotogaceae RepID=A8F6Y4_THELT Length = 315 Score = 102 bits (255), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 76/304 (25%), Positives = 136/304 (44%), Gaps = 36/304 (11%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG-------------- 65 +GQI +S E PP + + ++ +D L + F++VT A Sbjct: 12 KGQI-LSIEILPPNRGQNIEEIYAVLDELMNFPISFINVTKHAPEMTYLELEDGIVKVPK 70 Query: 66 -ERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG 124 +R T + + +R ++ PH+ C ++ + D G+R++ +RG+ Sbjct: 71 VKRPGTVGMTAALMNRYNIDVVPHVLCFGMNKYQIEDMLIDLHLIGVRNLFVIRGEYENQ 130 Query: 125 SGKPE---MYASDLVTLLKEV--------------ADFDISVAAYPEVHPEAKSAQADLL 167 + + + +ASDLV + + DF I VA YPE H EA + + D+ Sbjct: 131 TIEEKDSYSHASDLVKQISNMNMGEYLYPCENAKPTDFCIGVAGYPEKHFEAPNIEEDMR 190 Query: 168 NLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMT 227 LK+K+++GA+ ITQ FD + Y +F +R I+V IIPG+ PV + K Sbjct: 191 YLKKKIESGADYVITQMIFDFDVYKKFVERARQLSINVPIIPGVKPVVSLKSIYTIPRKF 250 Query: 228 NVRIP-AWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAI 286 V IP +++ QM + E + +G +V+ L G H +T+ + + + A+ Sbjct: 251 FVNIPESFVKQMQEAKTHREEFQ--IGTKYMAKLVEKLLSSGAPGVHVFTMGKGQSTKAL 308 Query: 287 CHTL 290 + Sbjct: 309 LEAV 312 >UniRef50_A8Q9P3 Methylenetetrahydrofolate reductase n=1 Tax=Malassezia globosa CBS 7966 RepID=A8Q9P3_MALGO Length = 515 Score = 101 bits (252), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 72/262 (27%), Positives = 120/262 (45%), Gaps = 50/262 (19%) Query: 48 LSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYW 107 +S L P+FV +T+ A D T ++K ++ G+E HLTC + ++ R+ Sbjct: 1 MSKLGPEFVDITWNAGGRTSDMTTQLVKTVQTYFGVETCMHLTCTNMPRSKIEVALREAK 60 Query: 108 NNGIRHIVALRGDLPPGSGKPE-------MYASDLVTLLKEVAD--FDISVAAYPEVHPE 158 G R+++ALRGD PP +G P +A +LV ++E F I+VA +PE HPE Sbjct: 61 EFGCRNVLALRGD-PPAAGSPWEPHAAGFSHAFELVQYIREHYGDYFSIAVAGFPEGHPE 119 Query: 159 AKSA-QADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNF 217 A + ++ +LK+K+DAGA+ TQ F+D+++++ + R +D PV Sbjct: 120 AVGGPELEMQHLKQKIDAGADFIFTQMFYDLDAFVNWTRRFFHDALD--------PVK-- 169 Query: 218 KQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSRE---GVKDFHF 274 +D E ++VG + DM K + + H Sbjct: 170 --------------------------EDDEQVRIVGTRLVGDMCKKILEHPDLDIHGVHI 203 Query: 275 YTLNRAEMSYAICHTLGVRPGL 296 YT+N S + LG+ P + Sbjct: 204 YTMNLERGSRMLLEYLGLTPSV 225 >UniRef50_B0VZI6 Methylenetetrahydrofolate reductase n=2 Tax=Culicini RepID=B0VZI6_CULQU Length = 443 Score = 92.8 bits (229), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 64/206 (31%), Positives = 102/206 (49%), Gaps = 15/206 (7%) Query: 85 AAPHLTCIDATPDEL-RTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLL--KE 141 A PHL+C + T ++ + + WN + +RGD G+ ++ DLV L K Sbjct: 233 AVPHLSCYNITETQVDKFVDMGNWN-----LFVIRGDTV-SEGQRFQHSCDLVEYLRAKN 286 Query: 142 VADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSA 201 D I V YP HPE+ S D+ LK+KVD G + +TQ +D S+L + D C A Sbjct: 287 NPDLTIGVGGYPYGHPESPSVDYDVKYLKQKVDLGVDFIVTQTLYDAASFLAYVDECRRA 346 Query: 202 GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFD--GLDDDAETRKLVGANIAMD 259 GI V I+PG+ + Q + +T V PA + ++ D+ + V + A + Sbjct: 347 GITVPIVPGLFLPGSPDQLETVLALTRVNPPAGVRELLQSHAHDEPDQFEAFVVKHFA-E 405 Query: 260 MVKILSRE---GVKDFHFYTLNRAEM 282 +++ L RE V+ HF+T NR ++ Sbjct: 406 LIRTLRRERPDEVRLVHFFTFNRLDL 431 >UniRef50_D0P2W8 Methylenetetrahydrofolate reductase n=1 Tax=Phytophthora infestans T30-4 RepID=D0P2W8_PHYIN Length = 244 Score = 87.8 bits (216), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 70/207 (33%), Positives = 107/207 (51%), Gaps = 20/207 (9%) Query: 7 SQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLS-SLKPKFVSVTYGANSG 65 S R A + + VSFEFFP +T+ L ++ + +L+P FV++T+ + Sbjct: 7 SIRSAYATRTDDTSARPTVSFEFFPAKTNAGVFNLLTRVEEMGLALQPTFVTLTWRSAFK 66 Query: 66 ERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS 125 + I I++ L+ HLTC T ++L+ I ++ GIR+I+ALRGD P G+ Sbjct: 67 DEALWLRIGAHIQNEFQLDVLLHLTCHLPT-EQLKRILKNARAAGIRNILALRGDPPIGA 125 Query: 126 GKPE------MYASDLVTLLKEVAD--FDISVAAYPEVH---------PEAKSAQA-DLL 167 + A DL+ L++E F I+ A Y EVH P + A+A DL Sbjct: 126 EQWSPVEGGLSNAVDLIKLIREEHGDYFCIACAGYAEVHTESWNHPDLPPSNEARALDLQ 185 Query: 168 NLKRKVDAGANRAITQFFFDVESYLRF 194 LK K DAGA+ ITQFFFDV++ + + Sbjct: 186 RLKAKQDAGADFIITQFFFDVDNMIHW 212 >UniRef50_UPI00019055D0 5,10-methylenetetrahydrofolate reductase protein n=2 Tax=Rhizobium etli RepID=UPI00019055D0 Length = 135 Score = 86.3 bits (212), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 36/91 (39%), Positives = 56/91 (61%) Query: 202 GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMV 261 GI + I+PGI+P+ N Q K+FA IP ++ + F G DD E R V A++A + + Sbjct: 33 GISIPIVPGIMPIQNVTQLKRFAGACGAVIPGFLDERFAGFDDKPEERAKVAADVAAEQI 92 Query: 262 KILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 + L R G++DFH YT+NR+ + A+ LG+ Sbjct: 93 EDLVRRGIRDFHLYTMNRSPLVSAVLDNLGL 123 >UniRef50_B2K1S3 Methylenetetrahydrofolate reductase n=22 Tax=Yersinia RepID=B2K1S3_YERPB Length = 266 Score = 83.6 bits (205), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 62/269 (23%), Positives = 119/269 (44%), Gaps = 16/269 (5%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 +SFE + + + ++ I+ +L P + +V S T+ + ++++T + Sbjct: 5 LSFEMNSAKNEKEMENIFKLIEFTDTLDPIYYTVNTEIGSSVWSDTYRTVIELREKTDVS 64 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP-GSGKPEMYASDLVTLLKEV- 142 PH+T + E+ I Y N GI +RGD P Y +L+ L++ Sbjct: 65 LIPHITINNKKEREIMQIIEKYINVGICEFFVIRGDKHVYDQDNPINYGVELIELIRRSH 124 Query: 143 ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAG 202 I + YP+ H E + ++ +RK G N I+Q + + L F +S Sbjct: 125 KHIGIKTSLYPDFHKETTEVKEEIDWNERKYQLGVNEFISQLTLNTNA-LDF----LSHW 179 Query: 203 IDVE--IIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDM 260 +D E P I+P+ NF +KF ++ P W+ + + + E ++ NI +++ Sbjct: 180 VDKERPFTPSIMPLGNFSFIEKFTSSNSIDYPLWIKKFANSKSNSNEDKE----NIGIEI 235 Query: 261 VKILSREGVKD---FHFYTLNRAEMSYAI 286 ++ L RE + H +TLN+ ++ I Sbjct: 236 IRFLCREYLNQRERLHVFTLNKVDVMKKI 264 >UniRef50_UPI0001698591 5,10-methylenetetrahydrofolate reductase n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2' RepID=UPI0001698591 Length = 99 Score = 75.5 bits (184), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 34/91 (37%), Positives = 59/91 (64%), Gaps = 1/91 (1%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 ++SFE FPP+T + + L +I +L+ KP++ SVTYGA ++RT + + ++++ G+ Sbjct: 10 SISFELFPPKTGQGFENLKRTISQLNQAKPEYFSVTYGAGGSTQERTFASVDWLREQ-GI 68 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHI 114 E APHL+CI A+ +E I + Y + G+ I Sbjct: 69 ETAPHLSCIGASVEETVAILQHYRDQGVNRI 99 >UniRef50_Q05FX5 Methylenetetrahydrofolate reductase n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FX5_CARRP Length = 239 Score = 75.1 bits (183), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 64/259 (24%), Positives = 106/259 (40%), Gaps = 28/259 (10%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 N+SFE FP + L I+ L+ KP FVSVT+G + + +K I+ + Sbjct: 3 NISFEIFPCNNIKDLSVL---INYLNKNKPSFVSVTFGKINNLK-----FVKNIQKQIST 54 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVA 143 + PHL C D + + I ++ + GD + +Y L + Sbjct: 55 KIIPHLIC-DNIFNIINYIIYFIKIKIFNFLI-ITGDKNKNNSIKYIYFIRF--LFGHII 110 Query: 144 DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGI 203 I Y E H +K+ + ++L +K G N ITQFF++ + + + GI Sbjct: 111 K--IITGCYFENHKFSKNFKNEILFHYKKNKIGTNMCITQFFYNFNTIKYYINIIKKTGI 168 Query: 204 DVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKI 263 I GI+ N K + ++ + IP W+ + + NI + VK Sbjct: 169 SKNFILGIISKKNIKDILNYTNLCKIDIPIWIIKNYKEF------------NIELFFVKN 216 Query: 264 LSREGVKDFHFYTLNRAEM 282 L + K+ HFYT N + Sbjct: 217 LKKY--KNLHFYTFNNINL 233 >UniRef50_B2Q6I6 Methylenetetrahydrofolate reductase n=1 Tax=Providencia stuartii ATCC 25827 RepID=B2Q6I6_PROST Length = 273 Score = 73.2 bits (178), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 55/250 (22%), Positives = 108/250 (43%), Gaps = 8/250 (3%) Query: 35 SEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDA 94 S+++ TL + + L P F +V E T++ +K+ T + PH+ + Sbjct: 21 SKIDNTLEHLLKNTEELTPLFYTVNTEIGKTEWRDTYNTCCELKNLTHVNVVPHIAINNK 80 Query: 95 TPDELRTIARDYWNNGIRHIVALRGDLPPGSGK-PEMYASDLVTLL-KEVADFDISVAAY 152 EL I +Y N I + +RGD + P Y +L+ + + + I + Y Sbjct: 81 DECELCFIIEEYLKNDITELFVIRGDRHRFDEELPFNYGIELIDFIRRRYPEVMIKSSIY 140 Query: 153 PEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGIL 212 P+ H E+ + + ++ L++K+ G I+Q + ++ + + G D+ I ++ Sbjct: 141 PDYHKESITPEIEIDWLRKKLQLGVTELISQLCLNKNAFSYMKKQ---LGNDIPITISMM 197 Query: 213 PVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDF 272 P+ NF + F + P W+ + + + G + ++ +E K Sbjct: 198 PMLNFSFIESFFKNNAIDYPLWIKKHIRP--SNINNHRAFGIQLTQFLIGEYIKEN-KRL 254 Query: 273 HFYTLNRAEM 282 HF+TLN AEM Sbjct: 255 HFFTLNNAEM 264 >UniRef50_Q5TWY6 Methylenetetrahydrofolate reductase n=1 Tax=Anopheles gambiae RepID=Q5TWY6_ANOGA Length = 320 Score = 65.9 bits (159), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 56/209 (26%), Positives = 100/209 (47%), Gaps = 19/209 (9%) Query: 89 LTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVAD---- 144 ++C + T ++ + R GIR++ +RGD G+ ++ LV L++ + Sbjct: 103 VSCYNITEQQVDQLLRA---TGIRNLFVIRGD-TVSPGQQFQNSAGLVQHLRKWQEQQPN 158 Query: 145 ---FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSA 201 F I+V YP H ++ S +L L+ K+ GA+ +TQ +D S+LR+RDRC A Sbjct: 159 HRQFTIAVGGYPYGHYQSSSQTVELHYLRAKISQGADFLLTQTLYDAPSFLRYRDRCREA 218 Query: 202 GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAE-------TRKLVG- 253 GI + IIPGI +++ + ++T + + + F+ +DA VG Sbjct: 219 GITIPIIPGIYVPHSYRHLQALLNLTRIELGPTVRDAFEAHANDAPDQFQAFMVEYFVGV 278 Query: 254 ANIAMDMVKILSREGVKDFHFYTLNRAEM 282 + M S + +K HF+T N+ + Sbjct: 279 VRELLQMNATTSSDPIKLVHFFTFNKFHL 307 >UniRef50_A7S5W8 Methylenetetrahydrofolate reductase n=1 Tax=Nematostella vectensis RepID=A7S5W8_NEMVE Length = 619 Score = 65.5 bits (158), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 80/285 (28%), Positives = 127/285 (44%), Gaps = 20/285 (7%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSSL---KPKFVSVTYG------ANSGERDRTHSIIKG 76 S E FPP+T +L+ + RL+ L KP F +T+ ++ T I Sbjct: 32 SVEIFPPKTFNGATSLFGIMCRLNELEDTKPLFADITWKPSKEPMSDKCLEPTTLLIAAS 91 Query: 77 IKDRTGLEAAPHLTCIDATPDEL---RTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS 133 + H+ T ++ A+++ GIR G + ++S Sbjct: 92 ARQVNNFNTIIHIPYFGTTRTQVFEHLMRAKEFGVCGIRAQRPAPGITYENPVHEDGFSS 151 Query: 134 --DLVTLLKEV--ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVE 189 DL+ +K+ DF I+V YP +DL LKR+VDAGA+ TQ FF+VE Sbjct: 152 IEDLIIFIKQEFGNDFAIAVTGYPS--QRCDWYDSDLALLKREVDAGADFITTQLFFEVE 209 Query: 190 SYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMT-NVRIPAWMAQMFDGLDDDAET 248 ++ +F C + GID+ IIPGILP+ N + + M V++P + ++ +D E Sbjct: 210 TFFKFERDCRNIGIDIPIIPGILPIQNLQTVRNLRKMNFAVKVPNEILEVLKSGKEDLEA 269 Query: 249 RKLVGANIAMDMVKILSREG-VKDFHFYTLNRAEMSYAICHTLGV 292 + G A M + L G V+ H YTLN + +I L + Sbjct: 270 IQAFGIQHATKMCQELFASGKVQGIHLYTLNIEKPVMSILENLKI 314 >UniRef50_B4LC84 Methylenetetrahydrofolate reductase n=3 Tax=Drosophila RepID=B4LC84_DROVI Length = 390 Score = 65.1 bits (157), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 58/237 (24%), Positives = 108/237 (45%), Gaps = 17/237 (7%) Query: 53 PKFVSVTY-----GANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYW 107 P F+S+ + ER T +I+ ++ T + A PHL+ T + + ++ Sbjct: 132 PTFISIVWLPQYWNVMPIERVETLQLIRNLE--THIPAMPHLSLFRQTKERID----EFL 185 Query: 108 NNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEV--ADFDISVAAYPEVHPEAKSAQAD 165 R+++A+RGD + Y+ LV + V + I+VA +P+ + A+ Sbjct: 186 ALNFRNMLAVRGD-KTHEDQVYRYSHQLVEHARRVRGVNISIAVAGHPQGYAGGPQGLAE 244 Query: 166 LLN-LKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA 224 + LK+K+D GA+ ITQ + E+ + F +AGI I+ G++ +FK Sbjct: 245 SIEMLKKKIDNGADFIITQLCYSPETIVEFLRGARNAGIQTPIMVGVVVPDSFKSYALIE 304 Query: 225 DMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKIL--SREGVKDFHFYTLNR 279 ++ + +PA + +D K +A+ ++ + + GV FYTLNR Sbjct: 305 MISKISLPAEARAEVEKYQNDDAKVKSYFVQLALRTIQQVLDANLGVHGIQFYTLNR 361 >UniRef50_D0RM84 Methylenetetrahydrofolate reductase n=1 Tax=Phytophthora infestans T30-4 RepID=D0RM84_PHYIN Length = 469 Score = 64.7 bits (156), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 29/104 (27%), Positives = 50/104 (48%) Query: 192 LRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKL 251 +++ +C AGI + I+PG LP+ N+ KF R+P + D + +D + Sbjct: 2 IQWITQCKDAGISIPILPGYLPIQNYSSFCKFTSWCKTRVPEKVLAALDAIKNDDAAVRR 61 Query: 252 VGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPG 295 G +A++ + L GV HFYT+N A + L ++P Sbjct: 62 YGTQLAVETCQRLLAAGVNSLHFYTMNLAATVTQVLEELQLQPA 105 >UniRef50_A4J5C2 Methylenetetrahydrofolate reductase n=5 Tax=Clostridiales RepID=A4J5C2_DESRM Length = 598 Score = 63.5 bits (153), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 67/289 (23%), Positives = 139/289 (48%), Gaps = 30/289 (10%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNS-IDRLSSLKPKFVSVTYGANSGERDRTHSIIKG-- 76 +G+ ++ E PP ++ + L N+ I + + ++T + R R SI+ Sbjct: 318 KGKFVIAVELDPPFNADTDLILQNAWICKDHGVD----AITIADSPMARARADSIMIAAK 373 Query: 77 IKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM---YAS 133 IK G+E PHL C D + L++ + IR+++A+ GD + K ++ + Sbjct: 374 IKREVGIEVLPHLCCRDKNLNALKSALLAGYIENIRNVLAITGDPVAIADKNDIKGVFNL 433 Query: 134 DLVTLLKEVADFDISVAAYPE--------VHPEAKSAQADLLNLKRKVDAGANRAITQFF 185 + + L++ ++ + + +PE ++ +A+L + +K+++GA +TQ Sbjct: 434 NSMKLIQLISTMNKEL--FPEDPINVGGALNLNLLKPEAELAKMVKKINSGATFFLTQPI 491 Query: 186 FDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGL-- 242 F E Y+ R ++ ++I+ GI+P+ ++K A ++ ++IP + ++ Sbjct: 492 F--EDYVINILRLINKNDGIKILGGIMPLVSYKNALFLNNEVAGIKIPERIINKYNSNMG 549 Query: 243 DDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTL 290 D+AE ++G IA+++ + +E V F+F T NR EM I L Sbjct: 550 KDEAE---IIGIEIAVEIANKI-KESVDGFYFITPFNRVEMIMKIIKKL 594 >UniRef50_A4TRX0 Methylenetetrahydrofolate reductase n=1 Tax=Yersinia pestis Pestoides F RepID=A4TRX0_YERPP Length = 187 Score = 63.5 bits (153), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 48/192 (25%), Positives = 85/192 (44%), Gaps = 16/192 (8%) Query: 102 IARDYWNNGIRHIVALRGDLPP-GSGKPEMYASDLVTLLKEV-ADFDISVAAYPEVHPEA 159 I Y N GI +RGD P Y +L+ L++ I + YP+ H E Sbjct: 3 IIEKYINVGICEFFVIRGDKHVYDQDNPINYGVELIELIRRSHKHIGIKTSLYPDFHKET 62 Query: 160 KSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVE--IIPGILPVSNF 217 + ++ +RK G N I+Q + + L F +S +D E P I+P+ NF Sbjct: 63 TEVKEEIDWNERKYQLGVNEFISQLTLNTNA-LDF----LSHWVDKERPFTPSIMPLGNF 117 Query: 218 KQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKD---FHF 274 +KF ++ P W+ + + + E ++ NI +++++ L RE + H Sbjct: 118 SFIEKFTSSNSIDYPLWIKKFANSKSNSNEDKE----NIGIEIIRFLCREYLNQRERLHV 173 Query: 275 YTLNRAEMSYAI 286 +TLN+ ++ I Sbjct: 174 FTLNKVDVMKKI 185 >UniRef50_Q67LF9 Methylenetetrahydrofolate reductase n=1 Tax=Symbiobacterium thermophilum RepID=Q67LF9_SYMTH Length = 326 Score = 63.5 bits (153), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 73/294 (24%), Positives = 126/294 (42%), Gaps = 47/294 (15%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSI-IKGIK 78 QG V+ E PPR + + TL +R+ + +V R I + + Sbjct: 36 QGAFCVTVEIDPPRGAGVAGTL----ERVRRFGDRVDAVNVADCPMANVRMSPITLAHLL 91 Query: 79 DRTG-LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASD 134 R G +EA HLT D L+ G+R+I+ALRGD P P+ ++ D Sbjct: 92 QRDGQVEAIFHLTTRDRNIIGLQAELLGAAGLGVRNILALRGDDPSRGDHPDARGVFEVD 151 Query: 135 LVTLLKEVA-----------------DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGA 177 + L++ A DF I A +P A +A++ L+ KV+AGA Sbjct: 152 TIGLIRLAAALNRGQTVSGTPLEQGTDFAIGCAC----NPAAADLEAEVSRLEEKVEAGA 207 Query: 178 NRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTN-----VRIP 232 + A TQ +D RF+ + ++ + + I+ G+LP+ ++ +FAD N + IP Sbjct: 208 HFAQTQPVYDPRQVERFQAK-LAGRVKIPILYGVLPLKSY----EFADRLNRTVPGIVIP 262 Query: 233 AWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAI 286 W+ G D++ G + ++++ + V H + +N A A+ Sbjct: 263 GWVLDRMRGRDEEE------GLRLTAELLREIGPH-VHGVHIFPMNSARRVVAV 309 >UniRef50_Q9VTI0 Methylenetetrahydrofolate reductase n=6 Tax=melanogaster group RepID=Q9VTI0_DROME Length = 349 Score = 62.8 bits (151), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 44/158 (27%), Positives = 72/158 (45%), Gaps = 14/158 (8%) Query: 147 ISVAAYPEVHPE----AKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAG 202 + V YPE + +++ ++ LK K+DAGA+ ITQ + E ++F C +AG Sbjct: 174 VCVGGYPEGYTSLGDIPQNSAKNMEFLKAKIDAGADCIITQLCYRPEVIVQFVKDCRAAG 233 Query: 203 IDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGL----------DDDAETRKLV 252 I V I+ G++ +F+ +T V +P + + D L D D R V Sbjct: 234 ISVPIVVGLMSHESFRSYSMIEQITGVHLPDDLREQLDQLHSAHMKDMKSDQDLIRRFFV 293 Query: 253 GANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + + + GV FHF+TLNR + A+ L Sbjct: 294 SLTVRTIRNVLDADVGVWGFHFFTLNRFKSVQAVLQEL 331 >UniRef50_D1CBD0 Methylenetetrahydrofolate reductase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CBD0_THET1 Length = 629 Score = 62.0 bits (149), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 59/220 (26%), Positives = 106/220 (48%), Gaps = 23/220 (10%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 +G+ VS E PP+ +TL + L+ K++++ + R ++ K I++ Sbjct: 329 RGEFIVSVEVDPPKGLSARKTLEGA-KMLAEKGVKWINIGDSPMARVRMSCIALAKLIQE 387 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASDLV 136 T +EA H T D +++ GIR+++AL GD P P+ ++ D V Sbjct: 388 TTPIEAIIHFTTRDRNVMAIQSDLIGAHAMGIRNVIALTGDPPSLGDYPDATGVWDIDSV 447 Query: 137 TLLKEVA----DFDIS-----------VAAYPEVHPEAKSAQADLLNLKRKVDAGANRAI 181 L+K ++ FD++ +AA V P AK + + + +K++AGA+ + Sbjct: 448 GLIKALSRMNEGFDLAGKQIGAKAGFCIAA--AVDPTAKDIEFQIDRMWQKIEAGAHLIM 505 Query: 182 TQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAK 221 +Q +DVE +F DR I V I G+LP+ ++K A+ Sbjct: 506 SQPLYDVEDLQKFLDRV--GNIPVPFILGVLPLQSYKHAE 543 >UniRef50_UPI000190699E 5,10-methylenetetrahydrofolate reductase protein n=1 Tax=Rhizobium etli GR56 RepID=UPI000190699E Length = 74 Score = 60.5 bits (145), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 27/61 (44%), Positives = 36/61 (59%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 I +SFEFFPP++ EME LWN++ L P FVSVTYGA + T + + +T Sbjct: 12 IGISFEFFPPKSEEMEGQLWNTVSELQDWDPDFVSVTYGAGGTTKAPTLTAVTRFLSQTP 71 Query: 83 L 83 L Sbjct: 72 L 72 >UniRef50_B0TCJ7 Methylenetetrahydrofolate reductase n=6 Tax=Bacteria RepID=B0TCJ7_HELMI Length = 258 Score = 59.3 bits (142), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 43/149 (28%), Positives = 68/149 (45%), Gaps = 5/149 (3%) Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVAD 144 A PH+ ID PD +A NGI ++ + GD PP ++Y + + +++ Sbjct: 68 AIPHIRAIDLNPDAPLQMAEQLQQNGIAEVLIVTGD-PPQDMSRKVYPTTSIDVIRRFKR 126 Query: 145 FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGID 204 + Y + P S + + +KRK+DAGA+ TQ FFD LRF + Sbjct: 127 ELPDMKVYAAIDPYRNSLRKEYDYIKRKIDAGADGFFTQPFFD----LRFMEIYGEMLEG 182 Query: 205 VEIIPGILPVSNFKQAKKFADMTNVRIPA 233 ++ GI PV+ K A + +V PA Sbjct: 183 QQVFWGISPVTTEKSACYWETKNHVLFPA 211 >UniRef50_B0K6M8 Methylenetetrahydrofolate reductase n=14 Tax=Clostridia RepID=B0K6M8_THEPX Length = 303 Score = 57.0 bits (136), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 60/227 (26%), Positives = 100/227 (44%), Gaps = 27/227 (11%) Query: 77 IKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYAS 133 ++D +EA HLTC D L++ + G+R+I+AL GD P P+ +Y Sbjct: 68 LQDHLNIEAIFHLTCRDRNLIGLQSELLGAYALGVRNILALTGDDPSRGDTPQAKGVYDV 127 Query: 134 DLVTLLKEVADFD-------------ISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRA 180 D + LLK ++ F+ A +P +A L LK K++AGA Sbjct: 128 DSIGLLKIISAFNRGYDYNGNKLDSPTEFCAGTTANPNDLRDEA-LEKLKVKIEAGAEFI 186 Query: 181 ITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD-MTNVRIPAWMAQMF 239 TQ +D E +F ++ +V ++ GILP+ ++K A + + + IP ++ Sbjct: 187 QTQPVYDEEILFKFIEKI--KNFNVPLLIGILPLKSYKMAVNLNEKVPGIDIP---EKVL 241 Query: 240 DGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAI 286 + L D G NIA++ +K + E V H L + I Sbjct: 242 ERLKDGGREE---GINIAVEFIKRIRSE-VAGIHIMPLGSTNVVLEI 284 >UniRef50_Q2LZ54 Methylenetetrahydrofolate reductase n=1 Tax=Drosophila pseudoobscura pseudoobscura RepID=Q2LZ54_DROPS Length = 433 Score = 57.0 bits (136), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 60/239 (25%), Positives = 108/239 (45%), Gaps = 18/239 (7%) Query: 53 PKFVSVTY-GANSGERDRTHSIIKGIKDRTGLEA----APHLTCIDATPDELRTIARDYW 107 P F+S+ + GA D ++ ++ LEA PHL+ T + L ++ Sbjct: 178 PTFLSIVWLGATYCSVDPIE-LVTSLQLARSLEARIPVMPHLSLYCLTEERLN----EFL 232 Query: 108 NNGIRHIVALRGDLPPGSGKPEMYASDLVT-LLKEVAD-FDISVAAYPEVH---PEAKSA 162 +++ +RGD G+ Y +V + ++ D I VA YPE + E + Sbjct: 233 ALNFTNVLPIRGD-AVKEGQTFRYTQQVVEHIRRQRGDRISICVAGYPEGYTNLAEPQDP 291 Query: 163 QADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKK 222 + LK K+ AGA+ ITQ + ++ ++F SAGI V I+ G L +F+ Sbjct: 292 AEAMRYLKAKIAAGADCIITQMCYRSDTIIQFIKDVRSAGITVPIVVGQLVADSFRTYCL 351 Query: 223 FADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVK-ILSRE-GVKDFHFYTLNR 279 ++ V +P + ++ DAE +++ +++ IL+ + GV FYT N+ Sbjct: 352 SENIAGVHLPPGLRSELLAIESDAERVSQFFIQLSIRIIRDILAADVGVYGVQFYTFNQ 410 >UniRef50_A7VPD0 Methylenetetrahydrofolate reductase n=1 Tax=Clostridium leptum DSM 753 RepID=A7VPD0_9CLOT Length = 600 Score = 55.8 bits (133), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 54/219 (24%), Positives = 103/219 (47%), Gaps = 20/219 (9%) Query: 77 IKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP----GSGKP--EM 130 ++ TG+E PH C D + LR + IR I+A+ GD P G KP + Sbjct: 378 LQRETGMEVLPHFCCRDRNVNALRAMLLGAQCENIRTILAVTGDHVPELDRGYIKPVFNV 437 Query: 131 YASDLVTLLKEV-----ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFF 185 ++ L+ ++ ++ AD ++ +P + +A+L L++K+ AGA +TQ Sbjct: 438 TSAKLMEMISQMNQDVFADSPFTIGG--AFNPNVANPKAELARLEKKLKAGAVFFLTQPV 495 Query: 186 FDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDD 244 FD ++ + + +++ GI+P+ +++ A ++ ++IP F Sbjct: 496 FDEGRISTVKE---AREMGAKMLLGIMPLVSYRNAVYMNNEVPGIQIPTAYVNRFSPEMS 552 Query: 245 DAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEM 282 E ++ G IA+++ + L R F+F T NRAE+ Sbjct: 553 REEAQR-TGIEIALEIAESL-RPHADGFYFMTPFNRAEI 589 >UniRef50_Q1AXR8 Methylenetetrahydrofolate reductase n=2 Tax=Bacteria RepID=Q1AXR8_RUBXD Length = 611 Score = 55.8 bits (133), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 57/232 (24%), Positives = 107/232 (46%), Gaps = 24/232 (10%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKG--IK 78 G V+ E PR +++ + + RL + ++ GA + R R H + ++ Sbjct: 329 GGFAVAVEVDLPRGNDLSGVV-EAARRLKERGADAIDISDGARA--RLRMHPVAAARIVQ 385 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD------LPPGSGKPEMYA 132 +R G+EA H++C D L+ G+R+I+A+ GD P +G + A Sbjct: 386 ERAGIEAVAHMSCRDRNILGLQADLLAAAALGVRNILAVTGDPAQIGDYPEATGVFDTDA 445 Query: 133 SDLVTLLKEV---ADFDISVAAYP-------EVHPEAKSAQADLLNLKRKVDAGANRAIT 182 LV +L + D + P +P A+ A++ L+RK++AGA+ T Sbjct: 446 VGLVHILSRMNRGEDLAGNAIGRPPGFLIGAAFNPTAEDLDAEVERLRRKLEAGAHAFWT 505 Query: 183 QFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPA 233 Q F++ + R +R G ++ G++P+ + +QA+ ++ V+IPA Sbjct: 506 QPVFELPALERALERL--EGTGARLLLGLMPLRSARQAEFLHHEVPGVKIPA 555 >UniRef50_C1F3L2 Methylenetetrahydrofolate reductase n=2 Tax=Bacteria RepID=C1F3L2_ACIC5 Length = 636 Score = 55.5 bits (132), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 54/225 (24%), Positives = 96/225 (42%), Gaps = 27/225 (12%) Query: 28 EFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEAAP 87 E PPR + ++ + + L+ L ++V + R S+ ++ ++G+E Sbjct: 342 EIVPPRGIDCQKEI-DGATMLAGLGVHVINVPDSPRASARMSAQSLCIQLQQKSGIETLL 400 Query: 88 HLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS------DLVTLLKE 141 H TC D +++ + G+R+I+ L GD P P+ A LV +++ Sbjct: 401 HYTCRDRNVLSIQSDLLGASSIGLRNILCLTGDPPKLGNYPDATAVFDVDAIGLVNIVRR 460 Query: 142 V--------------ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFD 187 + F I AA P V P+ + ++ KV+AGA AITQ FD Sbjct: 461 LNHGLDIGGNPIGASTGFTIGCAANPGV-PDIDN---EVRRFAYKVEAGAEYAITQPVFD 516 Query: 188 VESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIP 232 + F R G + +I GI P+++ + A+ + V +P Sbjct: 517 LRILESFLKRI--EGFRIPVIAGIWPLTSLRNAEFMRNDLRVSVP 559 >UniRef50_Q01QP4 Methylenetetrahydrofolate reductase n=2 Tax=Acidobacteria RepID=Q01QP4_SOLUE Length = 622 Score = 53.9 bits (128), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 54/262 (20%), Positives = 110/262 (41%), Gaps = 20/262 (7%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 G+ E PPR + + + + + ++V G + R + I+ + Sbjct: 338 GKFVTFVEILPPRGVDATREIAGA-KLCAEHGIDAINVPDGPRASARMSAQVTCQLIQAQ 396 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS---DLVT 137 G+EA H C D +++ G+R+++ + GD P P+ A D + Sbjct: 397 AGIEAVNHFCCRDRNILGIQSELLGTHGAGVRNLICITGDPPRMGAYPDATAVFDVDAIG 456 Query: 138 LLKEVADFD--ISVAAYP-----------EVHPEAKSAQADLLNLKRKVDAGANRAITQF 184 L+ V + + + + P +P A + ++ + KV+AGA +TQ Sbjct: 457 LVNIVRNLNHGLDIGGNPMGSQTALLIGVGANPGALNMDEEIRRFEWKVEAGAEYVVTQP 516 Query: 185 FFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDD 244 FD++ F R + + ++ GI P+++++ A+ + V +P + + D Sbjct: 517 VFDLDLLEAFLKRIEH--VKIPVLCGIWPLTSYRNAEFMVNELRVPVPEMFMERMRRV-D 573 Query: 245 DAETRKLVGANIAMDMVKILSR 266 +AE + G IA +MV +S+ Sbjct: 574 NAEKAREEGVAIAREMVARVSK 595 >UniRef50_A5UUW4 Methylenetetrahydrofolate reductase n=5 Tax=Chloroflexaceae RepID=A5UUW4_ROSS1 Length = 309 Score = 52.4 bits (124), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 63/284 (22%), Positives = 117/284 (41%), Gaps = 42/284 (14%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLS-SLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G I V+ E PPR + +++RL+ L+ ++ N R ++ GI Sbjct: 14 GHIVVTGEIAPPRGASRA-----TVERLALGLRDAVDAINLTDNQRGLGRMSALGAGIII 68 Query: 80 RT-GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE------MYA 132 R GLE +TC L+ GI + +A+ GD P P+ + + Sbjct: 69 RQLGLEPIVQMTCQHRNRIALQADVLSGAACGITNFLAMTGDHPKIGDHPDAKNVLDLNS 128 Query: 133 SDLVTLLKEVAD---------------FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGA 177 L+ +L+ + D F + A P + A+ L+RK+ GA Sbjct: 129 FQLLKMLRTMRDEGKFQSGVALTEAPRFFLGGVANPNIERVAR--------LERKIQFGA 180 Query: 178 NRAITQFFFDVESYLRFRDRCVSAGIDVE--IIPGILPVSNFKQAKKFAD-MTNVRIPAW 234 TQ FD++ + ++ +AG+ + I+ GI+ V + + A+ D + R+P W Sbjct: 181 EFIQTQILFDLDRFRQWMADARAAGLHQKAYILAGIMVVKSAQSARFLRDHLPGSRVPEW 240 Query: 235 MAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLN 278 + + + E + A +A +++ I EGV+ H ++ Sbjct: 241 VIERMERAAHPEEEGIAIAAELAQELLAI---EGVRGVHIMSVG 281 >UniRef50_A8SCX4 Methylenetetrahydrofolate reductase n=3 Tax=Clostridiales RepID=A8SCX4_9FIRM Length = 605 Score = 51.6 bits (122), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 46/237 (19%), Positives = 102/237 (43%), Gaps = 12/237 (5%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 GQ ++ E P+ +++ L + RL + +++ + R + + + Sbjct: 322 GQRVIAVELDSPKDADLTAYLEGA-RRLQAAGADLLTIADCPIARARMDSSLVACRVHRE 380 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM---------- 130 G+ PH+TC D + + + + G+R ++A+ GD P + + E+ Sbjct: 381 LGMNVLPHMTCRDRNLNATKALLLGLYAEGVREVLAITGDPIPTAERDEVKNVYQFNSRK 440 Query: 131 YASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES 190 A +V+L E + + + ++ A++ + +L K++ G + +TQ ++ Sbjct: 441 LAQYIVSLAGEGREMPSPITVFGALNLNARNFEVELRRAAEKLENGMSGFLTQPVLSAQA 500 Query: 191 YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTN-VRIPAWMAQMFDGLDDDA 246 + + G +I+ GILPV + + A + N + + + Q F+GLD A Sbjct: 501 VENLKKTRETLGERAKILAGILPVVSQRNAIFMENEVNGIHVDDAIIQRFEGLDRAA 557 >UniRef50_B7AQD9 Methylenetetrahydrofolate reductase n=1 Tax=Bacteroides pectinophilus ATCC 43243 RepID=B7AQD9_9BACE Length = 603 Score = 51.6 bits (122), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 58/256 (22%), Positives = 113/256 (44%), Gaps = 24/256 (9%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSV-TYGANSGERDRTHSIIKGIK- 78 G V+ E PP ++ ++ I++ LK V + T+ + R R S++ +K Sbjct: 327 GHKVVAVELDPPYDAKYDRL----IEQAQYLKSIGVDILTFADSPMGRSRVDSVLMSLKV 382 Query: 79 -DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG------SGKPEMY 131 TG+ PH+ C D +R+ + NGIR ++ + GD P +G + Sbjct: 383 TQETGMMVMPHVCCRDKNVIAMRSTLLGAYINGIRQLLLVTGDPVPSVSRVSTTGVFDYN 442 Query: 132 ASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLN-----LKRKVDAGANRAITQFFF 186 + L+ +KE+ A P + A + ++ +++K+D GA+ +TQ F Sbjct: 443 SIRLMNFVKEMNQEHF--ADEPLYYGGALNVTLGRIDRIMERMQKKIDNGASYFMTQPVF 500 Query: 187 DVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNVRIPAWMAQMFDGLDDD 245 E R + +D +I+ GI+P+ +++ A + + +P + + D Sbjct: 501 SKEGIERL--AIIKEKMDTKILCGIMPLVSYRNANFIKNEFIGIDVPDEIVARYSP-DMS 557 Query: 246 AETRKLVGANIAMDMV 261 E + VGA IA +++ Sbjct: 558 KEEGEAVGAQIANELI 573 >UniRef50_A9B657 Methylenetetrahydrofolate reductase n=1 Tax=Herpetosiphon aurantiacus ATCC 23779 RepID=A9B657_HERA2 Length = 617 Score = 51.6 bits (122), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 57/238 (23%), Positives = 106/238 (44%), Gaps = 33/238 (13%) Query: 6 ASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG 65 +++ L + LA+ G S E PP+ + L + ++ + F++V + Sbjct: 319 SAETTQLGRMLAD--GAFVTSVEIDPPKGHNPRRCLEGA-RQMQAAGVNFINVADSPMAR 375 Query: 66 ERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP--- 122 R + I+ + G+E H T D + L++ G+R+I+AL+GD P Sbjct: 376 VRMSALPMCNLIQQQVGMETILHFTTRDRSLMGLQSDLLGAHALGVRNILALKGDPPSFG 435 Query: 123 --PGSGKPEMYASDLVTLLKEVA-----------------DFDISVAAYPEVHPEAKSAQ 163 PG+ ++ D + L+K +A +F I VA ++ A+ Sbjct: 436 AYPGTSG--VFDVDTIGLVKVIAGMNSGVDTAGNDIGTPTNFLIGVA----LNINAEDPD 489 Query: 164 ADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAK 221 ++ L +KV AGA+ A+TQ +D RF D+ + + II G++PV +++ A Sbjct: 490 WEIDRLHQKVAAGAHYAMTQISYDATELDRFLDKL--GPLPIPIILGLMPVQSYRHAS 545 >UniRef50_B9DIA5 Methylenetetrahydrofolate reductase n=10 Tax=Staphylococcus RepID=B9DIA5_STACT Length = 613 Score = 51.2 bits (121), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 49/211 (23%), Positives = 94/211 (44%), Gaps = 27/211 (12%) Query: 77 IKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD------LPPGSGKPEM 130 IK +E H+TC D L++ GI I+A+ GD LP + ++ Sbjct: 373 IKQNYNIEPLVHITCRDRNLIGLQSHLLGLSLLGINEILAITGDPSKVGHLPGANNVYDV 432 Query: 131 YASDLVTL--------------LKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAG 176 + L L LK +F+I+ A P V + +A + L +K+D+G Sbjct: 433 NSKGLTELAVRFNQGLNIDGGALKTTTNFNIAGAFNPNV----RKMEAAVRRLDKKLDSG 488 Query: 177 ANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWM 235 N ITQ + VE ++ +A +D GI+P+++++ A+ ++ + +P + Sbjct: 489 MNYFITQPVYTVEKIQEIAEK--TAHLDSPFFIGIMPITSYRNAQFLHNEVPGITLPEDV 546 Query: 236 AQMFDGLDDDAETRKLVGANIAMDMVKILSR 266 + F+ + DD + K + I +V +++ Sbjct: 547 LEQFEAVKDDKQKTKELSLRICRKLVDEVTK 577 >UniRef50_B1GYU6 Methylenetetrahydrofolate reductase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=B1GYU6_UNCTG Length = 287 Score = 51.2 bits (121), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 63/249 (25%), Positives = 107/249 (42%), Gaps = 23/249 (9%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 ++ E FPP+ ++ L + D L L V+VT + R + ++ + + +R +E Sbjct: 16 ITAELFPPKGVDISSFLRRA-DCLYGLDA--VNVTDNQRASMRVSSLAMSRILIER-AIE 71 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP---GSGKPEMYASDLVTLLKE 141 LT D L++ GI +++ L GD P S +Y D + L+K Sbjct: 72 PILQLTARDRNRISLQSELLGANVLGIENVLLLSGDHPSIGECSDAKAVYDLDTIQLIKT 131 Query: 142 VADFDISV-------AAYPE------VHPEAKSAQADLLNLKRKVDAGANRAITQFFFDV 188 + V P+ V+P +S L L++KV AG TQ FDV Sbjct: 132 ARLLETGVDIAGKKLQGSPKFCVGAVVNPSVQSVDLQALMLEKKVKAGTEFFQTQAIFDV 191 Query: 189 ESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDD-AE 247 + Y F D+ + V+I+PG++ + + K + M+ V IP + + D AE Sbjct: 192 QIYKNFFDKV--KHLKVKILPGMILIKSPKFLQFLKSMSGVNIPDEIKDRINSASDPLAE 249 Query: 248 TRKLVGANI 256 + K+ A I Sbjct: 250 SIKICSATI 258 >UniRef50_Q2RJ84 Methylenetetrahydrofolate reductase n=2 Tax=Bacteria RepID=Q2RJ84_MOOTA Length = 306 Score = 50.4 bits (119), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 70/303 (23%), Positives = 127/303 (41%), Gaps = 41/303 (13%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFV-SVTYGANSGERDRTHSIIKGIK 78 QGQ VS E PP+ ++ I + ++L +V ++ N R SI G+ Sbjct: 12 QGQFLVSGEIGPPKHAD-----PTEIKKHAALLKDYVDAMNLTDNQTAIVRLSSIAAGVH 66 Query: 79 D-RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL------PPGSGKPEMY 131 + G E +T D L++ ++ G+R+++ L GD P ++ Sbjct: 67 VLQAGGEPIIQMTVRDRNRIALQSDLLGAYSLGMRNVLCLSGDHQSFGNHPTAKNVHDVD 126 Query: 132 ASDLVTLLKEVAD----------------FDISVAAYPEVHPEAKSAQADLLNLKRKVDA 175 + L+ ++K++ D F I AA P P + ++ L++K++A Sbjct: 127 SLQLIRIVKDLRDEKKFACGEEIKGQEPRFFIGAAANPFADP----FEFRVMRLEKKINA 182 Query: 176 GANRAITQFFFDVESYLRFRDRCVSAGID--VEIIPGILPVSNFKQAKKFAD-MTNVRIP 232 GA+ TQ FD+E + RF G+ +II G++P+ + + AK + + +P Sbjct: 183 GADFIQTQCIFDMERFERFMALVRERGLHKRAKIIAGVMPLKSARAAKYMQQSVAGMIVP 242 Query: 233 AWMAQMFDGLDDDAETRKLVGANIAMDMVKIL-SREGVKDFHFYTLNRAEMSYAICHTLG 291 + + D K G I ++ +K L S EGV H + ++ I G Sbjct: 243 DEIVNRMEKASDP----KAEGVAICVEQIKHLQSIEGVAGVHIMAVMWEDIIPTIVKEAG 298 Query: 292 VRP 294 + P Sbjct: 299 LYP 301 >UniRef50_B4MKM9 Methylenetetrahydrofolate reductase n=1 Tax=Drosophila willistoni RepID=B4MKM9_DROWI Length = 318 Score = 50.1 bits (118), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 53/244 (21%), Positives = 98/244 (40%), Gaps = 34/244 (13%) Query: 53 PKFVSVTYGANSG---ERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNN 109 P FVS+ + S D +S+ + + HL+ T + L ++ Sbjct: 74 PAFVSLVWLGISYWNIPMDENYSLQLAKHMESHIPVLAHLSAYRMTEERLN----EFLAK 129 Query: 110 GIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVA--DFDISVAAYPEVHPEAKSAQADLL 167 R+++ +RGD G+ Y +++ ++ + I V YPE + +L Sbjct: 130 NFRNVLIVRGD-EIHEGQKFTYGREMIEYARQQRKDNLSIGVPGYPEGY-HKNPINDPIL 187 Query: 168 N---LKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA 224 N LK K+ AG ITQ + + ++F + C A + V II GI+ + + Sbjct: 188 NIQYLKEKISAGGEFIITQTCYSSQKIIQFINDCREANVTVPIIIGIMVPDSVRNYHIVK 247 Query: 225 DMTNVRIPAWMAQMFDGLDDDAE---------TRKLVGANIAMDMVKILSREGVKDFHFY 275 ++T R+P + + DD + R + AN+ G++ F+ Sbjct: 248 NITGARLPNEVNDLSVNADDILKFFVDLTVRNIRDIFTANL-----------GIQGIQFF 296 Query: 276 TLNR 279 T+NR Sbjct: 297 TMNR 300 >UniRef50_B7RVE0 Methylenetetrahydrofolate reductase n=1 Tax=marine gamma proteobacterium HTCC2148 RepID=B7RVE0_9GAMM Length = 293 Score = 49.7 bits (117), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 54/232 (23%), Positives = 90/232 (38%), Gaps = 32/232 (13%) Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE------MYASDL 135 G+E +T D L++ W G++++V + GD P PE + DL Sbjct: 69 GVEPILQMTIRDRNRIALQSDMLGAWLLGVKNLVCMGGDPPHLGDHPEAKPVFDISTEDL 128 Query: 136 V--------------TLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAI 181 + LL F I V+P A+ ++ L+ KV AGA Sbjct: 129 IQAAGNLNNGKDMMDNLLSGSTGFHIGAV----VNPGAEDLDKEIARLESKVAAGAKFFQ 184 Query: 182 TQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD-MTNVRIPAWMAQMFD 240 TQ FD + + F +R + +D+ I+ GI+P+ + K A + + + +P + D Sbjct: 185 TQAIFDADRFAGFMERV--SHLDIAILAGIMPIKSVKMAAFMNEKIPGIDVPDHVIDRID 242 Query: 241 GLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 G D + V A I ++ I + H L E + GV Sbjct: 243 GAADTVKESTAVAAEIIKEIKPI-----CQGIHVMALGWEEHIPGVLQLAGV 289 >UniRef50_A5ZMW8 Methylenetetrahydrofolate reductase n=4 Tax=Clostridiales RepID=A5ZMW8_9FIRM Length = 292 Score = 49.7 bits (117), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 67/265 (25%), Positives = 116/265 (43%), Gaps = 32/265 (12%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 +G+ VS E PP+ +++ + + L + V+VT +S R + ++ K +KD Sbjct: 9 RGEFVVSAEVGPPKGIHVDELVEEAKTYLKDVHA--VNVTDNQSSVMRLGSLAMCKVLKD 66 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASDLV 136 G++ L C D L + GI +I+ L GD P+ ++ D V Sbjct: 67 -AGMDPIFQLACRDRNRIALESDLLSAAMFGIENILCLTGDHTKMGDHPQAKPVFDLDSV 125 Query: 137 TLLKEV----ADFDIS----VAAYPE------VHPEAKSAQADLLNLKRKVDAGANRAIT 182 +LL V + D+ V P+ V P + S A L ++RKV AGA+ T Sbjct: 126 SLLHTVKLLESGVDLGGNELVGEPPKFSKGAVVSPCSDSVDAQLAKMERKVAAGADYFQT 185 Query: 183 QFFFDVESYLRFRDRCVSAGIDVE---IIPGILPVSNFKQAKKFADMTNVRIPAWMAQMF 239 Q F+ E +++F ++ G V+ IIP + + F ++ + +P +M Sbjct: 186 QAVFEPEKFIKFMEKAKQFGKPVQVGIIIPKSVGMVRFMN----NNVAGIHVP---DEMI 238 Query: 240 DGLDDDAETRK--LVGANIAMDMVK 262 + L D E K + G IA ++K Sbjct: 239 EELKADKEKTKAGITGVEIAARIIK 263 >UniRef50_B6A4H7 Methylenetetrahydrofolate reductase n=2 Tax=Rhizobium leguminosarum RepID=B6A4H7_RHILW Length = 292 Score = 49.3 bits (116), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 48/158 (30%), Positives = 68/158 (43%), Gaps = 12/158 (7%) Query: 76 GIKDRTGLEAAPHLTC--IDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS 133 G++D G PH+ I P+ +AR G+RH + L GD +G A Sbjct: 66 GLRD-AGFVPVPHIVARNIRNRPELDTMLARLSEEAGVRHALVLGGDRDDAAGAFS-SAL 123 Query: 134 DLVT--LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRA-----ITQFFF 186 DL+ L + I++A YPE HP A D L KVDA A ++QF F Sbjct: 124 DLIETGLFQTYGIGRIAIACYPEGHPRIAGAVLDT-ALTAKVDAAARAGLDLLLVSQFLF 182 Query: 187 DVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA 224 D + L F R G+ V + GI + + K+A Sbjct: 183 DQKPLLSFARRLRERGVTVPLRVGIAGPAGRTKLLKYA 220 >UniRef50_C4GEB4 Methylenetetrahydrofolate reductase n=1 Tax=Shuttleworthia satelles DSM 14600 RepID=C4GEB4_9FIRM Length = 670 Score = 49.3 bits (116), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 51/250 (20%), Positives = 113/250 (45%), Gaps = 19/250 (7%) Query: 9 RDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERD 68 +DA Q L + G+ V+ E PR ++ + + + L +++ + R Sbjct: 377 QDAFYQKL--MSGRKVVAVELDSPRGCDITR-FMEAAENLKEAGADIITIADNPIAKAR- 432 Query: 69 RTHSIIKGI-KDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK 127 SI+ GI + + GL+A PH+TC D + +++ + GIR+++ + GD P + + Sbjct: 433 MDSSIVAGIIRRQVGLDALPHMTCRDRNLNATKSLLLGNYAQGIRNVLVITGDPIPSARR 492 Query: 128 PEMYA----------SDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGA 177 E+ + + L +E F + + ++ A++ + +L + KV AGA Sbjct: 493 DEVKVVYQFNSRKLMAYMKALGQEEGTFPSPMHIFGALNVNARNFEIELDRAREKVQAGA 552 Query: 178 NRAITQFFFDVES---YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPA 233 +TQ E+ R + + + ++ GI+PV + + + ++++ + +P Sbjct: 553 VGFLTQPALTTEAIANICRASETLRAENSRIRLLGGIIPVISERNGRFMQSEISGIDVPD 612 Query: 234 WMAQMFDGLD 243 + + + G D Sbjct: 613 ALIERYVGKD 622 >UniRef50_A4XIN5 Methylenetetrahydrofolate reductase n=1 Tax=Caldicellulosiruptor saccharolyticus DSM 8903 RepID=A4XIN5_CALS8 Length = 604 Score = 48.9 bits (115), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 57/242 (23%), Positives = 110/242 (45%), Gaps = 39/242 (16%) Query: 8 QRDALNQSLAEVQGQINVSF----EFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN 63 Q+ L + +E+ ++ F E PP+ E+E+T + L V++ Sbjct: 306 QKSILKDTPSELSQKLGKKFVFTVEISPPKGIELEKT-KEGVKLLKEAGADTVNIADSPM 364 Query: 64 SGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP 123 + R ++ +K+ G+E+ H TC D L++ G+++++AL GD PP Sbjct: 365 ARVRISPIALAHILKEELGVESILHFTCRDRNLISLQSELLGAAALGVKNVLALTGD-PP 423 Query: 124 GSG-----KP--EMYASDLVTLLKEV--------------ADFDISVAAYPEVHPEAKSA 162 G KP ++ + LV +L ++ +F I VA ++ A Sbjct: 424 SIGDYPQAKPVFDVNSEGLVLILNKLNSGTDYMGNPIGKATNFTIGVA----LNLNADDL 479 Query: 163 QADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIP---GILPVSNFKQ 219 ++ LKRK++ GA+ TQ ++VE+ +F ++ +D ++ P GILP+ + + Sbjct: 480 DKEIERLKRKIENGAHFIETQPIYEVEALEKFFEK-----VDFKLPPILGGILPLRSSRH 534 Query: 220 AK 221 A+ Sbjct: 535 AE 536 >UniRef50_B5YJV3 Methylenetetrahydrofolate reductase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=B5YJV3_THEYD Length = 295 Score = 48.5 bits (114), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 61/294 (20%), Positives = 115/294 (39%), Gaps = 27/294 (9%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIK-GI 77 + G ++ E PP+ ++ + +L LK +V + N R R S+ + Sbjct: 9 MSGDFVITVEITPPKGPDIT----GMVKKLEELKTMVDAVNFTDNPSARMRLCSLAACKL 64 Query: 78 KDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASD 134 G E + C D +++ GIR+++ + GD P E +Y D Sbjct: 65 SMDIGFEPVLQMACRDRNRLAIQSDLLGAHALGIRNLLVMTGDHPVWGDHREAKPVYDID 124 Query: 135 LVTLLKEVADFDISVAAYPE-------------VHPEAKSAQADLLNLKRKVDAGANRAI 181 L+K V + + + V+P A+ L ++K+ GA Sbjct: 125 SSILVKLVGNLNSGLDINGNKLNGKTEFFCGAVVNPNAEPLMPQLKRFEQKLKMGAEFFQ 184 Query: 182 TQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD-MTNVRIPAWMAQMFD 240 TQ F++E RF D S + ++I GI+ + K A + V +P+W+ + Sbjct: 185 TQMIFEIEKLERFID--YSKKFNTKVIAGIVLIRTKKMLHYLASKVPGVVMPSWLIDKIE 242 Query: 241 GLDDDAETRKLVGANIAMDMV-KILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 L+D E + G + A ++ ++ R+ H ++ E + L +R Sbjct: 243 RLND--EDVEKFGVDFAGSIILNLMERKLCDGVHIMAFSKVEEVKNLLDFLKIR 294 >UniRef50_Q189R6 Methylenetetrahydrofolate reductase n=6 Tax=Clostridium RepID=Q189R6_CLOD6 Length = 293 Score = 47.4 bits (111), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 66/300 (22%), Positives = 122/300 (40%), Gaps = 45/300 (15%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE------RDRTHSII 74 G+ V+ E PP+ +++ + + KP V + AN + R + + Sbjct: 11 GKFAVTTEMAPPKGTDLSHLIECA-------KP-LVGRVHAANVTDFQSAVMRATSLATC 62 Query: 75 KGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE----- 129 K +KD GLE +T D ++ GI +++AL GD P+ Sbjct: 63 KLLKD-AGLEPVIQITGRDRNRIAIQGEMLSAGVFGINNLLALTGDHTSVGDHPQAKGVF 121 Query: 130 --------------MYASDLV-TLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVD 174 M +D+ LK DF + + PE P + LL +K+K+ Sbjct: 122 DLDSVGILQTAETLMAGTDMAGNKLKGSPDFYLGASVTPEYSP----IEVQLLKMKKKIK 177 Query: 175 AGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPA 233 AGA TQ +D+ + +FR+ ++ +D +++ GI+P+ + AK A++ + +P Sbjct: 178 AGAKFFQTQALYDINTMRKFRE--LTRDMDCKVLAGIVPLKSPGMAKFMTANVPGIFVPD 235 Query: 234 WMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKD-FHFYTLNRAEMSYAICHTLGV 292 + + + G +A +++K L E + D H + E AI G+ Sbjct: 236 EQIERLRAAGKENWVSE--GIKMAGELIKQLKEEDLCDGVHIMAIGAEENIPAILDAAGL 293 >UniRef50_Q12UZ6 Methylenetetrahydrofolate reductase n=4 Tax=Methanosarcinaceae RepID=Q12UZ6_METBU Length = 294 Score = 47.0 bits (110), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 58/224 (25%), Positives = 96/224 (42%), Gaps = 22/224 (9%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 V+ E PP+ +++ TL ++ L +++T + R ++ K + D G E Sbjct: 16 VTAEVAPPKGTDISATLEDA--ELIRGLVDAINITDNQRAVMRMSPIAVGKLLMD-AGHE 72 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS---GKPEMYASDLVTLL-- 139 LTC D L++ GI ++ + GD G +Y D V LL Sbjct: 73 VIVQLTCRDRNRLALQSDILAASALGIENLCVMTGDYTTKGDHVGAKAVYDLDSVQLLSL 132 Query: 140 --KEVADFDIS---VAAYPEVHPEAKS-----AQADLLNLKRKVDAGANRAITQFFFDVE 189 K + D++ +A P A S + +L LK+K++AGA TQ +DVE Sbjct: 133 ITKMMGGSDMAGNELAGAPSFTVGAVSNTDVTKRMQMLKLKKKINAGARFIQTQAVYDVE 192 Query: 190 SYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPA 233 S+ F D G +V ++ GI+P+ ++ A N IP Sbjct: 193 SFKDFSDLMGQIGPNVLVLAGIIPL----RSAAMAHFMNNNIPG 232 >UniRef50_B0PF81 Methylenetetrahydrofolate reductase n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PF81_9FIRM Length = 582 Score = 47.0 bits (110), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 50/196 (25%), Positives = 83/196 (42%), Gaps = 23/196 (11%) Query: 67 RDRTHSIIKGIKDR--TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG 124 R R S++ K R G+E PH++C D LR GI ++ + GD P Sbjct: 345 RTRADSLMTAAKIRREAGIEVMPHISCRDKNHIALRAGLLGAAFEGIGRVLIVTGDPPMQ 404 Query: 125 SGKP------EMYASDLVTLLKEV-----ADFDISVAAYPEVHPEAKSAQADLLNLKRKV 173 +G + + DL+ + + AD + V+ A + A+L K+K+ Sbjct: 405 AGTRGSDGVYHLSSYDLIAWIHSMNSEVFADAPFLIGGALNVN--AANFDAELARAKKKL 462 Query: 174 DAGANRAITQFFFD---VESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNV 229 GA+ TQ F V+ +LR R D + GILPV+ +K A +++ + Sbjct: 463 SLGASMLFTQPIFSDKAVDHFLRARQELK----DCRLFAGILPVAGYKNALFLINEVSGI 518 Query: 230 RIPAWMAQMFDGLDDD 245 IP + + +G D Sbjct: 519 EIPDNVVRSLEGKTPD 534 >UniRef50_Q1NSQ8 Methylenetetrahydrofolate reductase n=3 Tax=Deltaproteobacteria RepID=Q1NSQ8_9DELT Length = 704 Score = 46.6 bits (109), Expect = 0.001, Method: Compositional matrix adjust. Identities = 52/210 (24%), Positives = 90/210 (42%), Gaps = 34/210 (16%) Query: 77 IKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EM 130 I+ G++ HLTC D L++ GI I+A+ GD S +P ++ Sbjct: 459 IQQEAGIKTIIHLTCRDRNALGLQSHIMGAHLLGIDSILAVTGDPATSSDQPGVSGVFDV 518 Query: 131 YASDLVTLL--------------KEVADFDISVA-AYPEVHPEAKSAQADLLNLKRKVDA 175 + LV ++ KE DF + VA +Y +P Q + L+RK Sbjct: 519 RSFGLVRMIDRFNQGFNMAGKNIKEKTDFSLGVAFSYRPSNP-----QVQIKRLERKAAL 573 Query: 176 GANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNVRIPAW 234 GA +TQ FF + ++ ++ +D+ I PGI P+ + + A ++ + IPA Sbjct: 574 GARYVMTQPFFAADEVEAMMEK--TSHLDLLIFPGIFPLISARNADFLHNEVPGISIPAT 631 Query: 235 MAQMFDGLDDDAETRKLVGANIAMDMVKIL 264 + Q + + R+ +AMD + L Sbjct: 632 LRQKLHQYEQVEDQRR-----VAMDFTREL 656 >UniRef50_C7MDX6 Methylenetetrahydrofolate reductase n=1 Tax=Brachybacterium faecium DSM 4810 RepID=C7MDX6_BRAFD Length = 274 Score = 46.6 bits (109), Expect = 0.001, Method: Compositional matrix adjust. Identities = 41/133 (30%), Positives = 60/133 (45%), Gaps = 5/133 (3%) Query: 80 RTGLEAAPHLTC-IDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTL 138 R G A PHL + P E+ + G+R + + GD P +G+ E A DL+ + Sbjct: 64 RHGFCAIPHLAARMLRDPGEVAEVLARLGEAGVREVFVIAGDAPHPAGRFE-GALDLLEV 122 Query: 139 LKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRC 198 L + + A+PE HP A A L+L R A A+TQ F+ L + R Sbjct: 123 LSP-SGMRAGIGAHPEGHPFLDEAAA--LSLLRAKAEHAAYAVTQMSFEAVPLLAWTRRL 179 Query: 199 VSAGIDVEIIPGI 211 GI + + PGI Sbjct: 180 REEGITLPVRPGI 192 >UniRef50_Q60FX0 Methylenetetrahydrofolate reductase n=1 Tax=Sphingomonas paucimobilis RepID=Q60FX0_PSEPA Length = 288 Score = 46.6 bits (109), Expect = 0.001, Method: Compositional matrix adjust. Identities = 68/245 (27%), Positives = 103/245 (42%), Gaps = 43/245 (17%) Query: 55 FVSVTY--GANSGERDRTHSIIKGIKDRTGLEAAPHLTC---IDATPDELRTIARDYWNN 109 +SVT+ GA +R R I+ G PHL+ ID +LRT D Sbjct: 42 LISVTFLPGAEYEDRARAAKRIQ----ELGFRPVPHLSARRLIDEA--DLRTYL-DMLKG 94 Query: 110 GI--RHIVALRGDLPPGSGKPEMYASDLVTL-----LKEVADFDISVAAYPEVHPE---- 158 I +H+ + GD +P D + L LKE ++ YPE HP+ Sbjct: 95 VIDLKHVFVIAGD----PNEPLGIYEDALALIDSGILKEYGIEHCGISGYPEGHPDITDE 150 Query: 159 --AKSAQADLLNLKRKVDAGANRAI-TQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVS 215 AK+ + +LKR+ G + +I TQF FD E L + + S GID + G+ + Sbjct: 151 KLAKAMHDKVASLKRQ---GIDYSIMTQFGFDAEPVLEWLKQIRSEGIDGPVRIGLAGPA 207 Query: 216 NFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGAN----IAMDMVKILSRE-GVK 270 + K +FA V A + + + GL L+G+ + D+ +L E G Sbjct: 208 SIKTLLRFAARCGVGTSAKVVKKY-GL----SITSLIGSAGPDPVIEDLTPVLGPEHGQV 262 Query: 271 DFHFY 275 HFY Sbjct: 263 HLHFY 267 >UniRef50_B9XKW8 Methylenetetrahydrofolate reductase n=1 Tax=bacterium Ellin514 RepID=B9XKW8_9BACT Length = 624 Score = 46.2 bits (108), Expect = 0.001, Method: Compositional matrix adjust. Identities = 53/213 (24%), Positives = 93/213 (43%), Gaps = 25/213 (11%) Query: 28 EFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKG--IKDRTGLEA 85 E PP++ +++ L + L FV T NS R ++ G +K++TG E Sbjct: 330 ELDPPKSLSLDKLLEGA-QALKQAGTDFV--TLADNSLAILRVSNMAAGFLVKEKTGAEP 386 Query: 86 APHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE----MYASDLVTLLKE 141 HL C D L++ GI H++AL GD P G + +Y + V L++ Sbjct: 387 LIHLACRDKNLIGLQSELMGLHALGIDHVLALTGD-PAKVGDHQEATSVYDVNSVGLIRM 445 Query: 142 VADFDISVAAYPE-------------VHPEAKSAQADLLNLKRKVDAGANRAITQFFFDV 188 + + AA +P A++ + + L+ K++AGA +TQ FD Sbjct: 446 IKRLNEGFAANGRDLKTKTQFVIGCAFNPNARNLDSQVRKLEDKLEAGAQFVMTQPIFD- 504 Query: 189 ESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAK 221 L + G+ V ++ G++P+ N + A+ Sbjct: 505 -PVLAKVTHEKTKGLGVPVLVGVMPLLNSRNAE 536 >UniRef50_Q3M8T4 Methylenetetrahydrofolate reductase n=56 Tax=Cyanobacteria RepID=Q3M8T4_ANAVT Length = 357 Score = 46.2 bits (108), Expect = 0.001, Method: Compositional matrix adjust. Identities = 74/307 (24%), Positives = 121/307 (39%), Gaps = 36/307 (11%) Query: 11 ALNQ-SLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDR 69 ALN S A G+ V+ E PP+ + + ++LK + +V S R Sbjct: 57 ALNYFSKAAQAGEFLVTAEVAPPKGGNPTHMM----EMAATLKGRVHAVNITDGSRAVLR 112 Query: 70 THSII-KGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP 128 S++ I + G+E + C D L+ GIR+I+AL GD P Sbjct: 113 MSSLVASAILLQQGIEPVCQMACRDRNRIALQADLMGAHALGIRNILALTGDPVKAGDHP 172 Query: 129 E------MYASDLVTLLKEV-------------ADFDISVAAYPEVHPEAKSAQADLLNL 169 E + A L+ L++++ D+ V A V P+ S Sbjct: 173 EAKAVFDLEAVRLLQLIRKMNQGVDCNDKPLTDGATDLFVGA--AVDPQCASWSGLQSRF 230 Query: 170 KRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD--MT 227 +RK++AGA +Q D E +F D+ S ++ GI + + K A +F + + Sbjct: 231 ERKIEAGAQFFQSQLITDFERLEKFMDKIASVH-KKPVLAGIFLLKSAKNA-QFINRCVP 288 Query: 228 NVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAIC 287 V IP + + D E G IA + V+I +R+ H + R ++ I Sbjct: 289 GVNIPEHIIERLAKAKDPLEE----GVKIAAEQVQI-ARQLCHGVHMMAVKREDLIPQIL 343 Query: 288 HTLGVRP 294 GV P Sbjct: 344 DLAGVSP 350 >UniRef50_Q2LQ11 Methylenetetrahydrofolate reductase n=1 Tax=Syntrophus aciditrophicus SB RepID=Q2LQ11_SYNAS Length = 618 Score = 45.8 bits (107), Expect = 0.002, Method: Compositional matrix adjust. Identities = 52/235 (22%), Positives = 90/235 (38%), Gaps = 29/235 (12%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 GQ S E PPR + L + R +++ G + R I Sbjct: 329 GQKVTSVEILPPRAGDFSNMLAK-VRRCHEAGVDAINIPDGPRASARVSPMITALVILRE 387 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASDLVT 137 G+E H C D +++ + G+ + + + GD P PE ++ D + Sbjct: 388 VGIEPVVHYCCRDRNLIGMQSDLLGGYAVGLVNYLIITGDPPKLGNCPEATGVFDVDSIG 447 Query: 138 LLKEVADFD-----------------ISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRA 180 L V + + I V A +P A + ++ +K++AGA A Sbjct: 448 LTSVVHNLNSGWDIGGSPVDPPTGIFIGVGA----NPCAVDLEREIDRYFQKIEAGAEFA 503 Query: 181 ITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWM 235 ITQ FD ++ RF DR V ++ G+ P+ +++ A+ N +P M Sbjct: 504 ITQPVFDEKALFRFLDRVEKHSKRVPVLAGVWPLLSYRN----AEFMNNEVPGVM 554 >UniRef50_C9KNQ4 Methylenetetrahydrofolate reductase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KNQ4_9FIRM Length = 247 Score = 45.8 bits (107), Expect = 0.002, Method: Compositional matrix adjust. Identities = 39/150 (26%), Positives = 66/150 (44%), Gaps = 7/150 (4%) Query: 84 EAAPHLTCIDATPDELRTIARDYW-NNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEV 142 E+ PH+ +D D+ +DY + IR ++ + GD PP E+Y ++ V ++ + Sbjct: 58 ESMPHIRAMDIDLDK-ELAMKDYLREHDIREVLVIEGD-PPQDMMHEVYPTNSVDVIWKF 115 Query: 143 ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAG 202 V Y + S +L +KRK+ AGA TQ FFD +RF Sbjct: 116 RKEMPEVKVYAGIDQYRGSLSQELYRIKRKLQAGAAGFFTQPFFD----MRFLSVYADML 171 Query: 203 IDVEIIPGILPVSNFKQAKKFADMTNVRIP 232 +E+ G+ PV + + + +V P Sbjct: 172 QGLEVYWGVSPVMSARSQSYWERKNHVVFP 201 >UniRef50_C4DNM1 Methylenetetrahydrofolate reductase n=1 Tax=Stackebrandtia nassauensis DSM 44728 RepID=C4DNM1_9ACTO Length = 289 Score = 45.4 bits (106), Expect = 0.002, Method: Compositional matrix adjust. Identities = 43/137 (31%), Positives = 58/137 (42%), Gaps = 14/137 (10%) Query: 82 GLEAAPHLTCIDATPD-ELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLK 140 GL PHL+ D EL + + + GIR + GD S D + LL+ Sbjct: 70 GLRPVPHLSARGMRDDAELVEVVQRLDHAGIRDAFVVGGDASSASA----VFPDGLALLQ 125 Query: 141 EVADF-----DISVAAYPEVHPEAKSAQA-DLLNLKRKVDAGANRAITQFFFDVESYLRF 194 + D DI + AYPE HP L KR+ A A+TQ FD E+ RF Sbjct: 126 AMDDIGHRLHDIGIPAYPEGHPSIDDDTLWAALAAKRRY---ATYAVTQLCFDAEAICRF 182 Query: 195 RDRCVSAGIDVEIIPGI 211 + G D+ I+ GI Sbjct: 183 TVQARQRGFDLPILAGI 199 >UniRef50_A8SPV0 Methylenetetrahydrofolate reductase n=2 Tax=Clostridiales RepID=A8SPV0_9FIRM Length = 606 Score = 45.1 bits (105), Expect = 0.003, Method: Compositional matrix adjust. Identities = 54/221 (24%), Positives = 92/221 (41%), Gaps = 19/221 (8%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSV-TYGANSGERDRTHSII--KGIKDRT 81 ++ E PP ++ L D LK V V T+ + R R SI+ + + T Sbjct: 337 IAVELAPPVDVNDQKLL----DAAHILKQSHVDVVTFPDSPSGRTRADSILMAEKVHKET 392 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP---EMYASDLVTL 138 GL PHL C D +R NGI+ + + GD P + ++ D V + Sbjct: 393 GLRVMPHLCCRDKNAIAIRGSVLGAQLNGIKDFLVITGDPVPVMFRQTTRSVFNFDSVGM 452 Query: 139 LKEVADFDISV------AAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYL 192 +K + + V ++ + + ++ +KRK++AGA ++Q F E Sbjct: 453 MKLLQTMNEEVFIGDKITYGGAINQNRINTKFEIDRIKRKLEAGAEFFLSQPVFSREQAQ 512 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNVRIP 232 RD G I+ GI+P+ + + A +MT + IP Sbjct: 513 ILRDMKAETG--ATILVGIMPLVSRRNALFMKNEMTGIEIP 551 >UniRef50_B8FFJ4 Methylenetetrahydrofolate reductase n=4 Tax=Bacteria RepID=B8FFJ4_DESAA Length = 295 Score = 45.1 bits (105), Expect = 0.003, Method: Compositional matrix adjust. Identities = 64/281 (22%), Positives = 120/281 (42%), Gaps = 25/281 (8%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 QG+ V+ E PP+ +E+ + + I+ L K ++VT +S R + +K+ Sbjct: 11 QGKFVVTSEVAPPKGVNLEK-MAHHIELLKD-KVDAMNVTDHQSSVMRFPSLGAALMVKE 68 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL------PPGSGKPEMYAS 133 G E +TC D L+ GI +++ L GD G ++ +S Sbjct: 69 MGG-EPILQMTCRDRNRLALQADLLFAHQRGINNVLCLTGDSVVLGDHKTAKGVFDLDSS 127 Query: 134 DLVTLLKEVA--------DFD--ISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQ 183 LV ++++ D D +S A V PEA Q L+ ++K++AGA TQ Sbjct: 128 QLVAAVRKLEKGKDMAGNDLDGAVSFCAGAIVTPEANPIQPQLIKFEKKIEAGAEFIQTQ 187 Query: 184 FFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGL 242 +D+E++ F + + V+++ GI+ +++ A+ ++ V +P Sbjct: 188 AVYDLENFKNFMEY--ARQFPVKVLAGIILLTSAPMARFMNKNVAGVTVPQVFIDEMASA 245 Query: 243 DDDAETRKLVGANIAMDMVKILSREGVKD-FHFYTLNRAEM 282 +K G IA +K + E + D H + + E+ Sbjct: 246 PKGGAIKK--GIEIAGRQIKQIVEENICDGVHIMAIGKEEL 284 >UniRef50_B9L045 Methylenetetrahydrofolate reductase n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=B9L045_THERP Length = 624 Score = 44.7 bits (104), Expect = 0.004, Method: Compositional matrix adjust. Identities = 56/219 (25%), Positives = 91/219 (41%), Gaps = 27/219 (12%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 VS E PP+ + + + L + +F++V + R ++ ++ TG+E Sbjct: 335 VSVEIDPPKGLNPSKAIEGA-RLLRQVGVEFINVADSPMARVRMSALALCVILQQETGVE 393 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASD---LVTL 138 HLT D L+ G+R+I+AL GD P P +Y D LV L Sbjct: 394 TILHLTTRDRNLMGLQADLLGAHALGVRNILALTGDPPTLGDYPHATPVYDLDSIGLVRL 453 Query: 139 LKEV--------------ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQF 184 L+ A F I VA P Q ++ L K+ AGA+ +TQ Sbjct: 454 LQNFRQGFDAGGASIGRPAMFTIGVAC----DPTRPDLQQEIERLHAKLAAGADFVMTQP 509 Query: 185 FFDVESYLRF--RDRCVSAGIDVEIIPGILPVSNFKQAK 221 FD ++ F + I+V ++ G+LP+ +F+ A Sbjct: 510 VFDFSTWRNFVAQYEIRYGPIEVPVLLGVLPLQSFRHAS 548 >UniRef50_B9MN09 Methylenetetrahydrofolate reductase n=2 Tax=root RepID=B9MN09_ANATD Length = 605 Score = 44.7 bits (104), Expect = 0.004, Method: Compositional matrix adjust. Identities = 56/242 (23%), Positives = 107/242 (44%), Gaps = 39/242 (16%) Query: 8 QRDALNQSLAEVQGQINVSF----EFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN 63 Q+ L + +E+ ++ F E PP+ E+E+T + L V++ Sbjct: 307 QKAVLKDTPSELSQKLGKKFIFTVEISPPKGIELEKT-KEGVKLLKEAGADTVNIADSPM 365 Query: 64 SGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP 123 + R ++ +K+ G+E+ H TC D L++ G+++++AL GD PP Sbjct: 366 ARVRISPIALAHILKEELGMESILHFTCRDRNLISLQSELLGAAALGVKNVLALTGD-PP 424 Query: 124 GSG-----KP--EMYASDLVTLLKEV--------------ADFDISVAAYPEVHPEAKSA 162 G KP ++ + LV +L + +F I VA ++ A Sbjct: 425 SIGDHPQAKPVFDVNSEGLVLILSRLNNGTDYMGNPIGKATNFTIGVA----LNLNADDL 480 Query: 163 QADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIP---GILPVSNFKQ 219 ++ LK K++ GA+ TQ ++ E+ RF ++ +D ++ P GILP+ + + Sbjct: 481 GKEIEKLKHKIENGAHFIETQPIYEPETLERFFEK-----VDFKLPPILGGILPLRSPRH 535 Query: 220 AK 221 A+ Sbjct: 536 AE 537 >UniRef50_D0LSQ2 Methylenetetrahydrofolate reductase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LSQ2_HALO1 Length = 643 Score = 44.7 bits (104), Expect = 0.004, Method: Compositional matrix adjust. Identities = 61/234 (26%), Positives = 95/234 (40%), Gaps = 27/234 (11%) Query: 7 SQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE 66 + R L LA GQ VS E P ++ + L N I L V++ G + Sbjct: 329 AMRSRLGARLA--AGQFAVSVELTAPAGTDDSKLLGN-IRTLLEAGVDVVNIADGPRASA 385 Query: 67 RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNN--GIRHIVALRGDLPPG 124 R ++ ++ TG+E H+ D + L IA + GIR++V + GD P Sbjct: 386 RTGNLAVCTKLQATTGVEPILHVCTRDR--NYLGLIAHLLGAHALGIRNMVIITGDPPKM 443 Query: 125 SGKP---EMYASDLVTLL--------------KEVADFDISVAAYPEVHPEAKSAQADLL 167 P +Y D + LL KE+ D S P A + ++ Sbjct: 444 GDYPFATPVYDVDSIGLLRMARTLNEGYDPAGKEI-DGHTSFVLATGAEPAATDYEREMR 502 Query: 168 NLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAK 221 L+ K AGA +TQ +D RF D G+ V + GILP+++ + A+ Sbjct: 503 RLEDKRAAGAELVMTQPVYDPRVLERFLDDAEPLGLPVMV--GILPLASHRNAE 554 >UniRef50_UPI0001AF0D23 5,10-methylenetetrahydrofolate reductase n=1 Tax=Streptomyces ghanaensis ATCC 14672 RepID=UPI0001AF0D23 Length = 290 Score = 44.3 bits (103), Expect = 0.005, Method: Compositional matrix adjust. Identities = 20/49 (40%), Positives = 28/49 (57%) Query: 138 LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFF 186 L++E FD +VAA+PE HP + D+ + K +GA AI Q FF Sbjct: 3 LVRECGAFDAAVAAFPERHPRSADRDDDIRHFVAKCRSGAGFAIIQMFF 51 >UniRef50_Q4W2U7 Methylenetetrahydrofolate reductase n=1 Tax=Rhodobacteraceae bacterium 179 RepID=Q4W2U7_9RHOB Length = 286 Score = 43.9 bits (102), Expect = 0.006, Method: Compositional matrix adjust. Identities = 45/176 (25%), Positives = 75/176 (42%), Gaps = 23/176 (13%) Query: 74 IKGIKDRTGLEAAPHLTCIDATP------------DELRTIARDYWNNGIRHIVALRGDL 121 I G +T ++AA L + P +E + + + +NG+ H + L G+ Sbjct: 51 ITGKNPQTQIDAAKQLLSMGYVPVVHMGARNFESDEEFVRLVQAHSDNGVTHGLFLGGN- 109 Query: 122 PPGSGKPEMYASDLVT--LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGAN- 178 P P A DL+T +L + + YPE HP+ +AQ L N +++ N Sbjct: 110 PLKHNGPLHEAMDLLTHDVLPDTCMTHAFIGGYPEGHPDIDTAQ--LENARKQKLEACNA 167 Query: 179 -----RAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNV 229 I+QF FD ++ + + DV I G+ V++ + KFA M V Sbjct: 168 IGLKPEIISQFAFDGDTMAAWATKMSQEEPDVPIRLGLAGVTSLHKLIKFAVMCGV 223 >UniRef50_C4Z117 Methylenetetrahydrofolate reductase n=1 Tax=Eubacterium eligens ATCC 27750 RepID=C4Z117_EUBE2 Length = 595 Score = 43.9 bits (102), Expect = 0.006, Method: Compositional matrix adjust. Identities = 62/277 (22%), Positives = 118/277 (42%), Gaps = 22/277 (7%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSV-TYGANSGERDRTHSII--KG 76 +G+ ++ E PP + E+ + D +K V V T+ + R R SI+ + Sbjct: 317 EGRKLIAVELAPPLGIDDEKIM----DAAFLMKESGVDVLTFPDSPSGRTRADSILMAEK 372 Query: 77 IKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG---SGKPEMYAS 133 + TG+ PH+ C D +R+ N I + + + GD P + ++ Sbjct: 373 VSRETGMCVMPHICCRDKNAIAMRSQLLGAHINDINNFLVITGDPIPSVVRASVKSVFNF 432 Query: 134 DLVTLLKEVADFDI-SVAAYPEVHPEAKSA-----QADLLNLKRKVDAGANRAITQFFFD 187 D V L+ ++D + A P ++ A + + +L +K+K++AGA +TQ F Sbjct: 433 DSVGLMNIISDMNQEQFAGKPVIYGGAINQGRVNFKVELERVKKKMEAGATFFMTQPVFS 492 Query: 188 VESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNVRIPAWMAQMFDGLDDDA 246 E R R + I+ GI+P + + A +MT + + + + D Sbjct: 493 DEDIDRLRQ--IKEQTGARILCGIMPFVSLRNATFMKNEMTGINVTDEILSRYRA-DMSK 549 Query: 247 ETRKLVGANIAMDMVKILSREGVKDFHF-YTLNRAEM 282 E + G IA +++ + + V ++F + NR M Sbjct: 550 EEGEETGIQIAREIIA-KTTDFVDGYYFSFPFNRVHM 585 >UniRef50_Q64DN7 5-10-methylenetetrahydrofolate reductase n=3 Tax=environmental samples RepID=Q64DN7_9ARCH Length = 306 Score = 43.5 bits (101), Expect = 0.009, Method: Compositional matrix adjust. Identities = 47/214 (21%), Positives = 85/214 (39%), Gaps = 27/214 (12%) Query: 34 TSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKG------IKDRTGLEAAP 87 T E+E ++ + + V + N + ++ + + I+ TG+E Sbjct: 21 TGELEPEKAGDVNEPIEMARELVGMVVACNVTDNPQSFAYVNSMAASYLIQKETGMECVY 80 Query: 88 HLTCIDATPDELRTIARDYWNNGIRHIVALRGD------LPPGSGKPEMYASDLVTLLKE 141 L C D L + G+++I+AL GD P ++ ++ L+ L++ Sbjct: 81 QLRCSDRNRMALLSDVLGAGALGLKNILALAGDHVSLGDTPDAKPVFDLDSTTLIKLIRT 140 Query: 142 VADFDISVAAYPEVHPEAK------------SAQADLLNLKRKVDAGANRAITQFFFDVE 189 + D D E+H K +A++ +KRK++AG TQ + + Sbjct: 141 MVD-DGKDLGGNEIHNPPKLHVGGAAAPGAAHLKAEVGKVKRKINAGVEYLQTQVVYYTD 199 Query: 190 SYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF 223 +F D +DV I+ GI P F QA F Sbjct: 200 VLDKFFDEL--GKVDVPILVGIFPARTFGQADFF 231 >UniRef50_A6UAD8 Methylenetetrahydrofolate reductase n=11 Tax=Proteobacteria RepID=A6UAD8_SINMW Length = 367 Score = 43.5 bits (101), Expect = 0.009, Method: Compositional matrix adjust. Identities = 33/131 (25%), Positives = 63/131 (48%), Gaps = 8/131 (6%) Query: 169 LKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVE--IIPGILPVSNFKQAKKF-AD 225 L +K++AGA +Q+ FDV + + + G+ + I+ G+ P+++ K A+ ++ Sbjct: 195 LAKKIEAGAQFVQSQYCFDVPMFREYMKKVRDLGLHEKCFILVGVGPLASAKTARWIRSN 254 Query: 226 MTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMD-MVKILSREGVKDFHFYTLNRAEMSY 284 + + IP + + +G A+ +K G + +D M ++ EGV H + E Sbjct: 255 VPGIHIPDGIIRRLEG----AQDQKKEGKQLCIDVMNEVKEIEGVSGVHVMAYRQEEYVA 310 Query: 285 AICHTLGVRPG 295 I H GV G Sbjct: 311 EIVHESGVLRG 321 >UniRef50_B9JGE7 Methylenetetrahydrofolate reductase n=3 Tax=Rhizobiales RepID=B9JGE7_AGRRK Length = 368 Score = 42.4 bits (98), Expect = 0.017, Method: Compositional matrix adjust. Identities = 32/131 (24%), Positives = 64/131 (48%), Gaps = 8/131 (6%) Query: 169 LKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVE--IIPGILPVSNFKQAKKF-AD 225 L +K++AGA +Q+ +DV + + + G+ + I+ G+ P+++ K A+ ++ Sbjct: 196 LAKKIEAGAQFVQSQYCYDVPMFRDYMKKVRDLGLHEKCFILVGVGPLASAKTARWMRSN 255 Query: 226 MTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMV-KILSREGVKDFHFYTLNRAEMSY 284 + V IP + + +G AE +K G + +D++ ++ EGV H + E Sbjct: 256 VPGVHIPDEIIKRIEG----AEDQKKEGKQLCIDIINEVKEIEGVSGVHVMAYRQEEYVA 311 Query: 285 AICHTLGVRPG 295 + H GV G Sbjct: 312 EMVHDSGVLKG 322 >UniRef50_A1AKP7 Methylenetetrahydrofolate reductase n=10 Tax=Desulfuromonadales RepID=A1AKP7_PELPD Length = 615 Score = 42.4 bits (98), Expect = 0.017, Method: Compositional matrix adjust. Identities = 56/242 (23%), Positives = 104/242 (42%), Gaps = 26/242 (10%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFV-SVTYGANSGERDRTHSIIKG--IKDRT 81 ++ E PP+ + + I+ LK V ++ N R R +I G I+ + Sbjct: 326 ITVELDPPKGLDCSRI----IEGCRRLKRAGVDAINLAENPLARPRMGNIALGSLIQQQV 381 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD---LPPGSGKPEMYASDLVTL 138 G+ H+T D +++ GIR ++A+ GD + +G ++ +TL Sbjct: 382 GIPVIIHVTGRDRNLIGMQSDLMGASLLGIRSVLAVTGDPATMGDHAGATSVFDLHSLTL 441 Query: 139 LKEVADFDISVAAY-------------PEVHPEAKSAQADLLNLKRKVDAGANRAITQFF 185 +K +AD + V A +P A+ L++KV GA A TQ Sbjct: 442 IKLLADLNRGVNAMGNPIGGGAGFTIGAAFNPNARDMAGQASRLRKKVANGAMFAQTQPI 501 Query: 186 FDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDD 244 +D + L F+ ++A + +IPGI+P+ + + A ++ + IP + GL+ Sbjct: 502 YD--AGLFFQALELTADCAIPLIPGIMPLVSQRNADYLHNEVPGISIPETVLARMCGLEK 559 Query: 245 DA 246 +A Sbjct: 560 EA 561 >UniRef50_D1N227 Methylenetetrahydrofolate reductase n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N227_9BACT Length = 605 Score = 42.0 bits (97), Expect = 0.023, Method: Compositional matrix adjust. Identities = 55/207 (26%), Positives = 85/207 (41%), Gaps = 30/207 (14%) Query: 77 IKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP---EMYAS 133 I+ G+E H C D + L+ GI +I+ + GD P P ++ Sbjct: 380 IQRNAGIETILHCCCRDKSLIGLQADLLGCAGVGINNILFITGDPPKLGDYPFSSGVFDV 439 Query: 134 DLVTLLK-----------------EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAG 176 D V L+K V I V A P A + + KV+AG Sbjct: 440 DSVGLVKIQKRMNQGVDLGGKPLNAVTKMVIGVGA----DPNAIDLEREYRRTCEKVEAG 495 Query: 177 ANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIP-AW 234 A ITQ F E+ F DR A ++V +I GI P+++ + A+ ++ V +P A Sbjct: 496 AEFIITQPVFAPEALFVFLDRV--AHLNVPVIAGIWPLTSLRNAEFMRTEVPGVVVPDAV 553 Query: 235 MAQMFDGLDDDAETRKLVGANIAMDMV 261 M +M D+ E ++ G IA + V Sbjct: 554 MERM--AADESKEAQREAGIAIARESV 578 >UniRef50_A8ZTK4 Methylenetetrahydrofolate reductase n=24 Tax=Bacteria RepID=A8ZTK4_DESOH Length = 321 Score = 42.0 bits (97), Expect = 0.024, Method: Compositional matrix adjust. Identities = 53/237 (22%), Positives = 98/237 (41%), Gaps = 29/237 (12%) Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL------PPGSGKPEMYASDL 135 G+E + C D ++ + GIR+I+AL GD P G ++ + L Sbjct: 72 GVEPNYQMVCRDRNRLAMQADILGAYALGIRNILALSGDHQQFGDHPFAKGVYDLDSIQL 131 Query: 136 VTLLKEVAD-------FDISVAAYP-------EVHPEAKSAQADLLNLKRKVDAGANRAI 181 V ++K + D DIS +P +P A+ + + L +K+DAGA+ Sbjct: 132 VNMIKNMRDEGKFQGGADIS---HPPKMFIGAAANPFAEPYEWRVHRLAKKIDAGADFVQ 188 Query: 182 TQFFFDVESYLRFRDRCVSAGI--DVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQM 238 TQ F++E + + + G+ + I+ GI P+ + A+ + + +P + + Sbjct: 189 TQCIFNMERFREWIRQANDMGLTEKIYILGGITPMKSIGMARYMQKKVPGMDVPEAIIKR 248 Query: 239 FDGLDDDAETRKLVGANIAMDMVKILSR-EGVKDFHFYTLNRAEMSYAICHTLGVRP 294 G+D + G IA + ++ L +GV H + I G+ P Sbjct: 249 LQGVDKKEVANE--GIKIACEQIQELKETKGVAGVHLMAIEWEHKVPEIAEKAGMLP 303 >UniRef50_B9KZH8 Methylenetetrahydrofolate reductase n=2 Tax=Thermomicrobia (class) RepID=B9KZH8_THERP Length = 299 Score = 42.0 bits (97), Expect = 0.025, Method: Compositional matrix adjust. Identities = 43/142 (30%), Positives = 62/142 (43%), Gaps = 19/142 (13%) Query: 82 GLEAAPHLTCIDA-TPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLK 140 G PHL + EL + + + GI + + GD +P D TLL Sbjct: 74 GYRVVPHLAARALRSHQELVLLWQQFVAAGIDEVFVVGGD----QTEPAGEFPDSRTLLT 129 Query: 141 EVADFD-----ISVAAYPEVHPE--AKSAQADLLNLKRKVDAGANRAITQFFFDVESYLR 193 + + I +AAYPE HP A ADLL + A A+ AITQ FD ++ +R Sbjct: 130 ALVELQPRPRRIGIAAYPEGHPHIPADVLDADLLTKQ----ALADYAITQLVFDPDALVR 185 Query: 194 FRDRCVSAGIDVEI---IPGIL 212 + R S G + + +PG L Sbjct: 186 WLTRMRSRGFTLPLYLCLPGTL 207 >UniRef50_C6VPC5 Methylenetetrahydrofolate reductase n=3 Tax=Lactobacillus plantarum RepID=C6VPC5_LACPJ Length = 618 Score = 41.6 bits (96), Expect = 0.033, Method: Compositional matrix adjust. Identities = 55/268 (20%), Positives = 115/268 (42%), Gaps = 29/268 (10%) Query: 16 LAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIK 75 L +V Q E PPR + + + +RL + ++++ + + R +I Sbjct: 320 LQKVATQKTALVELDPPRDFDTTK-FFRGAERLKAAGVDGITLSDNSLATVRIANTTIAA 378 Query: 76 GIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD------LPPGSGKPE 129 +K G+ HLT D L++ + GI I+A+ GD P + + Sbjct: 379 QLKLNYGITPIVHLTTRDHNLIGLQSEIMGLHSLGIEDILAITGDPAKLGDFPGATSVSD 438 Query: 130 MYASDLVTL--------------LKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDA 175 + + +L+ L LKE +DF ++ A P + + S ++ + RK+ Sbjct: 439 VRSVELMKLIKQFNSGIGPTGKSLKEASDFRVAGAFNPNAYRTSISTKS----ISRKLSY 494 Query: 176 GANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIP-A 233 G + ITQ +D+ + D + ++V + G++P+ + + A+ ++ +RIP Sbjct: 495 GCDYIITQPVYDLANVDALADALAANHVNVPVFVGVMPLVSRRNAEFLHHEVHGIRIPEP 554 Query: 234 WMAQMFDGLDDDAETRKLVGANIAMDMV 261 + +M + + + VG IA +++ Sbjct: 555 ILTRMAEA--EQTGNERAVGIAIAKELI 580 >UniRef50_A9QPD6 Methylenetetrahydrofolate reductase n=1 Tax=Methylacidiphilum infernorum V4 RepID=A9QPD6_METI4 Length = 617 Score = 41.2 bits (95), Expect = 0.039, Method: Compositional matrix adjust. Identities = 44/179 (24%), Positives = 75/179 (41%), Gaps = 21/179 (11%) Query: 88 HLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG----KPEMYASDLVTLLKEVA 143 H+ C D L++ G RHI+AL GD P SG +Y + V L++ +A Sbjct: 396 HVACRDRNLLGLQSELMGLGTLGFRHILALTGD-PAKSGDHPGATSVYDLNSVGLIRLLA 454 Query: 144 DFDISVAAYPE-------------VHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES 190 + V A + +P A + L+ K+ AGA +TQ FD E Sbjct: 455 GLNRGVNAAGKDLKGKTDFIIGCAFNPNTVQFDAQVRKLEAKLAAGARFVMTQPVFDFEL 514 Query: 191 YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDDDAET 248 + + G+ V + GI+P+ N++ A+ ++ + IP + L+ + T Sbjct: 515 IKKIFNYLKPLGVPVFV--GIMPILNYRNAEFLHNEVPGISIPEKIRSRMKDLEGEKAT 571 >UniRef50_C8WWX3 Methylenetetrahydrofolate reductase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WWX3_ALIAD Length = 637 Score = 40.8 bits (94), Expect = 0.051, Method: Compositional matrix adjust. Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 32/212 (15%) Query: 77 IKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD------LPPGSGKPEM 130 +K R G+E H+TC D ++ GIR+++ + GD LP + ++ Sbjct: 397 LKQR-GIEPLVHVTCRDRNLIGQQSHLMGLAVLGIRNVLLVTGDPSRYGELPGATSVYDV 455 Query: 131 YASDLVTL--------------LKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAG 176 + DL + LK+ + F I A P VH K+ + L+RKV+AG Sbjct: 456 SSMDLTKMVRRLNEGIGFSGQPLKQPSRFVIGTAFNPHVHNFRKAVE----RLRRKVEAG 511 Query: 177 ANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAW- 234 A+ +TQ FD + G+ V + GI+P+++ + A+ + +R+ Sbjct: 512 ADFVMTQPVFDPNLMAAIAEATRDLGVPVFV--GIMPLTSARNAEFLHHQVPGIRLSEQA 569 Query: 235 MAQMFDGLDDDAETRKLVGANIAMDMVKILSR 266 + +M + ++A VG IA ++V++ R Sbjct: 570 LRRMQEAAPEEAPA---VGEAIARELVEVAIR 598 >UniRef50_UPI0001BCEC92 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein n=1 Tax=Selenomonas noxia ATCC 43541 RepID=UPI0001BCEC92 Length = 597 Score = 40.8 bits (94), Expect = 0.056, Method: Compositional matrix adjust. Identities = 54/250 (21%), Positives = 107/250 (42%), Gaps = 25/250 (10%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVS-VTYGANSGERDRTHS-IIKG-IKDRT 81 ++ E PP T ++ L + L+ +S +T N R R + ++ G + Sbjct: 320 IAVELDPPETGNADKFLVG----VRELQAAGISAITIADNPIARARMDAAMLAGRVHREL 375 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYA--------- 132 G+E PH+TC D + +++I G+ +++A+ GD P + + E+ + Sbjct: 376 GIEPIPHMTCRDRNLNAIKSILLGLSAEGVHNMIAITGDPIPTAERDEVKSVYQFNSRKL 435 Query: 133 SDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFD---VE 189 + VT L D + + ++ AK + L ++K++AG TQ E Sbjct: 436 ASFVTSLGSRGDI-VPFHVFGALNVNAKHFPSQLGLARKKMEAGMTGFFTQPVLSERAKE 494 Query: 190 SYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDDDAET 248 + RD A I+ GI+PV + + A+ +++ + + + + GLD A Sbjct: 495 NLQTARDMLPGA----FILGGIMPVVSERNARFMESEIVGIHVEERIISAYRGLDRTAAE 550 Query: 249 RKLVGANIAM 258 V ++A+ Sbjct: 551 ELAVRLSLAI 560 >UniRef50_C7MZV4 Methylenetetrahydrofolate reductase n=1 Tax=Saccharomonospora viridis DSM 43017 RepID=C7MZV4_SACVD Length = 292 Score = 40.8 bits (94), Expect = 0.059, Method: Compositional matrix adjust. Identities = 37/136 (27%), Positives = 60/136 (44%), Gaps = 8/136 (5%) Query: 80 RTGLEAAPHLTCIDATPD-ELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTL 138 R G PHL D +R + G+ + + GD P +G+ A L+ Sbjct: 69 RHGYTVTPHLAARQFVDDNHVREVIDRLQTAGVNSVFIVGGDAPKPAGRFH-SAYMLLQA 127 Query: 139 LKEVAD--FDISVAAYPEVHPEAKSAQADL-LNLKRKVDAGANRAITQFFFDVESYLRFR 195 ++E+ ++ + YPE H A Q+D+ L LK+K A R +TQ FD + + Sbjct: 128 MQELGHPFSEVGIGGYPEGH--ANIPQSDIELALKQKAPL-ATRILTQICFDANTTANWA 184 Query: 196 DRCVSAGIDVEIIPGI 211 +GID+ I G+ Sbjct: 185 AGVAKSGIDLPIYVGM 200 >UniRef50_C0QIT4 Methylenetetrahydrofolate reductase n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QIT4_DESAH Length = 274 Score = 40.0 bits (92), Expect = 0.086, Method: Compositional matrix adjust. Identities = 23/65 (35%), Positives = 33/65 (50%), Gaps = 2/65 (3%) Query: 156 HPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVS 215 HPE + L++KVDAGA +TQ +D S R + G+ + +I GILP+ Sbjct: 147 HPEINGFDLAVDRLRKKVDAGAGFVVTQPVYDRASAERI--AVATQGLGIPVILGILPLR 204 Query: 216 NFKQA 220 K A Sbjct: 205 TLKHA 209 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_P71319 5,10-methylenetetrahydrofolate reductase n=247 T... 424 e-117 UniRef50_B7VLL7 Methylenetetrahydrofolate reductase n=16 Tax=Pro... 403 e-111 UniRef50_O67422 5,10-methylenetetrahydrofolate reductase n=9 Tax... 379 e-104 UniRef50_Q0CXY7 Methylenetetrahydrofolate reductase n=18 Tax=Dik... 367 e-100 UniRef50_Q9SE60 Methylenetetrahydrofolate reductase 1 n=8 Tax=Vi... 362 1e-98 UniRef50_B9HG95 Methylenetetrahydrofolate reductase n=6 Tax=rosi... 362 1e-98 UniRef50_B2IJ01 Methylenetetrahydrofolate reductase n=5 Tax=Alph... 361 1e-98 UniRef50_A6C2T8 Methylenetetrahydrofolate reductase n=1 Tax=Plan... 358 1e-97 UniRef50_O80585 Methylenetetrahydrofolate reductase 2 n=14 Tax=E... 357 3e-97 UniRef50_Q3SVZ0 Methylenetetrahydrofolate reductase n=69 Tax=Pro... 354 2e-96 UniRef50_Q89B13 5,10-methylenetetrahydrofolate reductase n=74 Ta... 352 9e-96 UniRef50_Q2ILB5 Methylenetetrahydrofolate reductase n=15 Tax=Bac... 352 9e-96 UniRef50_Q3A3T2 Methylenetetrahydrofolate reductase n=20 Tax=Bac... 350 3e-95 UniRef50_B2UQZ6 Methylenetetrahydrofolate reductase n=3 Tax=Verr... 350 4e-95 UniRef50_A1WXM6 Methylenetetrahydrofolate reductase n=221 Tax=Ba... 349 7e-95 UniRef50_O54235 5,10-methylenetetrahydrofolate reductase n=40 Ta... 346 6e-94 UniRef50_B7G287 Methylenetetrahydrofolate reductase n=3 Tax=stra... 346 8e-94 UniRef50_A0LTK4 Methylenetetrahydrofolate reductase n=19 Tax=Act... 345 9e-94 UniRef50_C1ZF18 Methylenetetrahydrofolate reductase n=1 Tax=Plan... 344 3e-93 UniRef50_Q0AYF5 Methylenetetrahydrofolate reductase n=10 Tax=Bac... 343 4e-93 UniRef50_D1Y625 Methylenetetrahydrofolate reductase n=1 Tax=Pyra... 342 1e-92 UniRef50_B5JFK7 Methylenetetrahydrofolate reductase n=1 Tax=Verr... 341 2e-92 UniRef50_B9XQY3 Methylenetetrahydrofolate reductase n=2 Tax=Verr... 341 2e-92 UniRef50_C1SKU9 Methylenetetrahydrofolate reductase n=1 Tax=Deni... 339 6e-92 UniRef50_Q5FNV4 Methylenetetrahydrofolate reductase n=1 Tax=Gluc... 339 7e-92 UniRef50_C7LW31 Methylenetetrahydrofolate reductase n=2 Tax=Desu... 337 3e-91 UniRef50_C6NUC2 Methylenetetrahydrofolate reductase n=1 Tax=Acid... 337 3e-91 UniRef50_Q21NJ7 Methylenetetrahydrofolate reductase n=2 Tax=Gamm... 336 4e-91 UniRef50_B6FS52 Methylenetetrahydrofolate reductase n=1 Tax=Clos... 336 5e-91 UniRef50_P53128 Methylenetetrahydrofolate reductase 2 n=42 Tax=A... 336 7e-91 UniRef50_D2QYY6 5,10-methylenetetrahydrofolate reductase n=3 Tax... 334 3e-90 UniRef50_A8NEV2 Methylenetetrahydrofolate reductase n=2 Tax=Agar... 334 3e-90 UniRef50_Q04NW1 Methylenetetrahydrofolate reductase n=5 Tax=Lept... 332 1e-89 UniRef50_D1B7X9 Methylenetetrahydrofolate reductase n=1 Tax=Ther... 332 1e-89 UniRef50_B9WCV3 Methylenetetrahydrofolate reductase n=10 Tax=Sac... 331 1e-89 UniRef50_B1ZNX1 Methylenetetrahydrofolate reductase n=2 Tax=Opit... 331 2e-89 UniRef50_P42898 Methylenetetrahydrofolate reductase n=58 Tax=Met... 331 3e-89 UniRef50_D0RN29 Methylenetetrahydrofolate reductase n=1 Tax=alph... 329 6e-89 UniRef50_B1L1W9 Methylenetetrahydrofolate reductase n=30 Tax=Bac... 329 9e-89 UniRef50_C5FI42 Methylenetetrahydrofolate reductase n=1 Tax=Micr... 329 1e-88 UniRef50_Q0AZY6 Methylenetetrahydrofolate reductase n=5 Tax=Clos... 328 2e-88 UniRef50_A6TTI5 Methylenetetrahydrofolate reductase n=3 Tax=Clos... 327 2e-88 UniRef50_A2QUJ5 Methylenetetrahydrofolate reductase n=16 Tax=Leo... 327 3e-88 UniRef50_Q2HBA5 Methylenetetrahydrofolate reductase n=2 Tax=Leot... 327 3e-88 UniRef50_C8V780 Methylenetetrahydrofolate reductase n=17 Tax=Leo... 327 4e-88 UniRef50_Q5KN82 Methylenetetrahydrofolate reductase n=1 Tax=Filo... 326 7e-88 UniRef50_D1ZNB9 Methylenetetrahydrofolate reductase n=1 Tax=Sord... 325 8e-88 UniRef50_C5RR04 Methylenetetrahydrofolate reductase n=1 Tax=Clos... 325 9e-88 UniRef50_Q28TL9 Methylenetetrahydrofolate reductase n=3 Tax=Rhod... 325 1e-87 UniRef50_UPI0001C36AF7 5,10-methylenetetrahydrofolate reductase ... 325 1e-87 UniRef50_C5DIA7 Methylenetetrahydrofolate reductase n=2 Tax=Sacc... 325 1e-87 UniRef50_A8MFK9 Methylenetetrahydrofolate reductase n=7 Tax=Clos... 324 2e-87 UniRef50_C4XPB4 Methylenetetrahydrofolate reductase n=11 Tax=Del... 324 3e-87 UniRef50_C7N1R9 Methylenetetrahydrofolate reductase n=2 Tax=Cori... 323 4e-87 UniRef50_Q17693 Probable methylenetetrahydrofolate reductase n=5... 323 4e-87 UniRef50_C4R2L4 Methylenetetrahydrofolate reductase n=1 Tax=Pich... 323 4e-87 UniRef50_C4Y9Q4 Methylenetetrahydrofolate reductase n=1 Tax=Clav... 323 5e-87 UniRef50_Q169G2 Methylenetetrahydrofolate reductase n=39 Tax=Rho... 323 6e-87 UniRef50_P46151 Methylenetetrahydrofolate reductase 1 n=10 Tax=S... 322 8e-87 UniRef50_C0WB69 Methylenetetrahydrofolate reductase n=1 Tax=Acid... 320 5e-86 UniRef50_C6PS47 Methylenetetrahydrofolate reductase n=1 Tax=Clos... 320 5e-86 UniRef50_C9RM26 Methylenetetrahydrofolate reductase n=23 Tax=Bac... 319 8e-86 UniRef50_Q30YC4 Methylenetetrahydrofolate reductase n=5 Tax=Desu... 319 8e-86 UniRef50_A9UZU5 Methylenetetrahydrofolate reductase n=1 Tax=Mono... 319 1e-85 UniRef50_A1W0I6 Methylenetetrahydrofolate reductase n=14 Tax=Cam... 318 2e-85 UniRef50_Q0FF75 Methylenetetrahydrofolate reductase n=1 Tax=Rhod... 318 2e-85 UniRef50_C5L500 Methylenetetrahydrofolate reductase n=2 Tax=Perk... 315 1e-84 UniRef50_A8XGR9 Methylenetetrahydrofolate reductase n=1 Tax=Caen... 314 2e-84 UniRef50_A6UBB8 Methylenetetrahydrofolate reductase n=45 Tax=Rhi... 312 7e-84 UniRef50_Q6CEM7 Methylenetetrahydrofolate reductase n=1 Tax=Yarr... 311 1e-83 UniRef50_C8W5Z9 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 311 1e-83 UniRef50_A4E8J9 Methylenetetrahydrofolate reductase n=1 Tax=Coll... 311 2e-83 UniRef50_B3W8E2 Methylenetetrahydrofolate reductase n=15 Tax=Bac... 310 3e-83 UniRef50_C0EZI4 Methylenetetrahydrofolate reductase n=1 Tax=Euba... 310 4e-83 UniRef50_A8ZV44 Methylenetetrahydrofolate reductase n=2 Tax=Desu... 309 8e-83 UniRef50_B8BVS6 Methylenetetrahydrofolate reductase n=1 Tax=Thal... 309 1e-82 UniRef50_A5EYC8 Methylenetetrahydrofolate reductase n=2 Tax=Card... 304 2e-81 UniRef50_C7NEN8 Methylenetetrahydrofolate reductase n=8 Tax=Fuso... 304 2e-81 UniRef50_A8PLM8 Methylenetetrahydrofolate reductase n=1 Tax=Rick... 303 6e-81 UniRef50_Q4Q0B9 Methylenetetrahydrofolate reductase n=3 Tax=Leis... 302 1e-80 UniRef50_B7GRV7 Methylenetetrahydrofolate reductase n=16 Tax=Bif... 300 4e-80 UniRef50_B9Z0I7 Methylenetetrahydrofolate reductase n=1 Tax=Luti... 300 4e-80 UniRef50_Q4P1E8 Methylenetetrahydrofolate reductase n=1 Tax=Usti... 300 5e-80 UniRef50_C4ZCX7 Methylenetetrahydrofolate reductase n=2 Tax=Firm... 299 7e-80 UniRef50_Q058D8 Methylenetetrahydrofolate reductase n=1 Tax=Buch... 299 8e-80 UniRef50_Q5M088 Methylenetetrahydrofolate reductase n=47 Tax=Fir... 297 2e-79 UniRef50_B7GB47 Methylenetetrahydrofolate reductase (Fragment) n... 296 7e-79 UniRef50_A0JXH6 Methylenetetrahydrofolate reductase n=6 Tax=Micr... 294 2e-78 UniRef50_O74927 Methylenetetrahydrofolate reductase 2 n=2 Tax=Sc... 294 2e-78 UniRef50_C8NQ26 Methylenetetrahydrofolate reductase n=20 Tax=Cor... 294 4e-78 UniRef50_A3H552 Methylenetetrahydrofolate reductase (Fragment) n... 292 1e-77 UniRef50_C9L8P5 Methylenetetrahydrofolate reductase n=1 Tax=Blau... 289 9e-77 UniRef50_D1U6W4 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 289 1e-76 UniRef50_C2EUU9 Methylenetetrahydrofolate reductase n=2 Tax=Lact... 287 4e-76 UniRef50_C6BZ56 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 287 5e-76 UniRef50_C4R2Q6 Methylenetetrahydrofolate reductase n=6 Tax=Sacc... 283 6e-75 UniRef50_A8QAM7 Methylenetetrahydrofolate reductase n=1 Tax=Mala... 282 1e-74 UniRef50_C0QAY2 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 281 2e-74 UniRef50_B2A780 Methylenetetrahydrofolate reductase n=1 Tax=Natr... 280 5e-74 UniRef50_D1BTF0 Methylenetetrahydrofolate reductase n=2 Tax=Acti... 278 2e-73 UniRef50_D1PME0 Methylenetetrahydrofolate reductase n=1 Tax=Subd... 277 3e-73 UniRef50_Q03V90 Methylenetetrahydrofolate reductase n=2 Tax=Leuc... 275 1e-72 UniRef50_Q2S0T1 Methylenetetrahydrofolate reductase n=4 Tax=cell... 272 9e-72 UniRef50_C3PE90 Methylenetetrahydrofolate reductase n=8 Tax=Cory... 271 2e-71 UniRef50_D0JBB4 Methylenetetrahydrofolate reductase n=31 Tax=Bac... 270 3e-71 UniRef50_A9BEZ6 Methylenetetrahydrofolate reductase n=2 Tax=Ther... 269 7e-71 UniRef50_D1BI58 Methylenetetrahydrofolate reductase n=2 Tax=Micr... 267 3e-70 UniRef50_C7QYL7 Methylenetetrahydrofolate reductase n=2 Tax=Acti... 266 5e-70 UniRef50_A7TTE9 Methylenetetrahydrofolate reductase n=2 Tax=Sacc... 266 6e-70 UniRef50_C5BVR3 Methylenetetrahydrofolate reductase n=1 Tax=Beut... 265 1e-69 UniRef50_B5Y6J3 Methylenetetrahydrofolate reductase n=2 Tax=Bact... 262 1e-68 UniRef50_A6L1E2 Methylenetetrahydrofolate reductase n=45 Tax=Bac... 258 1e-67 UniRef50_B2GHG1 Methylenetetrahydrofolate reductase n=1 Tax=Kocu... 257 2e-67 UniRef50_A8F6Y4 Methylenetetrahydrofolate reductase n=2 Tax=Ther... 256 6e-67 UniRef50_A8Q9P3 Methylenetetrahydrofolate reductase n=1 Tax=Mala... 255 1e-66 UniRef50_A6W769 Methylenetetrahydrofolate reductase n=1 Tax=Kine... 253 3e-66 UniRef50_D0YUL0 Methylenetetrahydrofolate reductase n=1 Tax=Mobi... 246 8e-64 UniRef50_B7AVK8 Methylenetetrahydrofolate reductase n=1 Tax=Bact... 242 1e-62 UniRef50_UPI00015B5A5C PREDICTED: hypothetical protein n=1 Tax=N... 239 9e-62 UniRef50_C2KSD1 Methylenetetrahydrofolate reductase n=2 Tax=Mobi... 236 6e-61 UniRef50_A6W6I5 Methylenetetrahydrofolate reductase n=1 Tax=Kine... 235 1e-60 UniRef50_Q8KTS2 Methylenetetrahydrofolate reductase n=1 Tax=Cand... 233 7e-60 UniRef50_C7M2P8 Methylenetetrahydrofolate reductase n=1 Tax=Acid... 228 2e-58 UniRef50_C0W5C3 Methylenetetrahydrofolate reductase n=1 Tax=Acti... 220 4e-56 UniRef50_Q67LF9 Methylenetetrahydrofolate reductase n=1 Tax=Symb... 218 2e-55 UniRef50_D0P2W8 Methylenetetrahydrofolate reductase n=1 Tax=Phyt... 215 2e-54 UniRef50_A7S5W8 Methylenetetrahydrofolate reductase n=1 Tax=Nema... 210 6e-53 UniRef50_A9B657 Methylenetetrahydrofolate reductase n=1 Tax=Herp... 207 5e-52 UniRef50_D1CBD0 Methylenetetrahydrofolate reductase n=1 Tax=Ther... 204 3e-51 UniRef50_Q2LQ11 Methylenetetrahydrofolate reductase n=1 Tax=Synt... 204 3e-51 UniRef50_Q2RJ84 Methylenetetrahydrofolate reductase n=2 Tax=Bact... 202 1e-50 UniRef50_B0VZI6 Methylenetetrahydrofolate reductase n=2 Tax=Culi... 201 2e-50 UniRef50_B5YJV3 Methylenetetrahydrofolate reductase n=1 Tax=Ther... 201 2e-50 UniRef50_Q3M8T4 Methylenetetrahydrofolate reductase n=56 Tax=Cya... 201 2e-50 UniRef50_B4LC84 Methylenetetrahydrofolate reductase n=3 Tax=Dros... 201 3e-50 UniRef50_B0K6M8 Methylenetetrahydrofolate reductase n=14 Tax=Clo... 201 3e-50 UniRef50_Q01QP4 Methylenetetrahydrofolate reductase n=2 Tax=Acid... 200 5e-50 UniRef50_C1F3L2 Methylenetetrahydrofolate reductase n=2 Tax=Bact... 197 3e-49 UniRef50_A4XIN5 Methylenetetrahydrofolate reductase n=1 Tax=Cald... 196 6e-49 UniRef50_Q2LZ54 Methylenetetrahydrofolate reductase n=1 Tax=Dros... 195 1e-48 UniRef50_B2K1S3 Methylenetetrahydrofolate reductase n=22 Tax=Yer... 194 3e-48 UniRef50_A4J5C2 Methylenetetrahydrofolate reductase n=5 Tax=Clos... 194 4e-48 UniRef50_A5UUW4 Methylenetetrahydrofolate reductase n=5 Tax=Chlo... 191 2e-47 UniRef50_A5ZMW8 Methylenetetrahydrofolate reductase n=4 Tax=Clos... 190 7e-47 UniRef50_A7VPD0 Methylenetetrahydrofolate reductase n=1 Tax=Clos... 188 2e-46 UniRef50_B2Q6I6 Methylenetetrahydrofolate reductase n=1 Tax=Prov... 187 4e-46 UniRef50_B7RVE0 Methylenetetrahydrofolate reductase n=1 Tax=mari... 186 6e-46 UniRef50_Q189R6 Methylenetetrahydrofolate reductase n=6 Tax=Clos... 185 2e-45 UniRef50_C4GEB4 Methylenetetrahydrofolate reductase n=1 Tax=Shut... 183 7e-45 UniRef50_A8SCX4 Methylenetetrahydrofolate reductase n=3 Tax=Clos... 180 4e-44 UniRef50_Q9VTI0 Methylenetetrahydrofolate reductase n=6 Tax=mela... 180 5e-44 UniRef50_B1GYU6 Methylenetetrahydrofolate reductase n=1 Tax=uncu... 180 6e-44 UniRef50_B4MKM9 Methylenetetrahydrofolate reductase n=1 Tax=Dros... 179 1e-43 UniRef50_B0PF81 Methylenetetrahydrofolate reductase n=1 Tax=Anae... 178 2e-43 UniRef50_Q12UZ6 Methylenetetrahydrofolate reductase n=4 Tax=Meth... 177 4e-43 UniRef50_B9XKW8 Methylenetetrahydrofolate reductase n=1 Tax=bact... 176 6e-43 UniRef50_Q1AXR8 Methylenetetrahydrofolate reductase n=2 Tax=Bact... 171 3e-41 UniRef50_B7AQD9 Methylenetetrahydrofolate reductase n=1 Tax=Bact... 170 4e-41 UniRef50_Q1NSQ8 Methylenetetrahydrofolate reductase n=3 Tax=Delt... 170 5e-41 UniRef50_B9DIA5 Methylenetetrahydrofolate reductase n=10 Tax=Sta... 166 8e-40 UniRef50_Q5TWY6 Methylenetetrahydrofolate reductase n=1 Tax=Anop... 158 2e-37 UniRef50_Q05FX5 Methylenetetrahydrofolate reductase n=1 Tax=Cand... 148 2e-34 UniRef50_A4TRX0 Methylenetetrahydrofolate reductase n=1 Tax=Yers... 141 3e-32 UniRef50_D0RM84 Methylenetetrahydrofolate reductase n=1 Tax=Phyt... 124 3e-27 UniRef50_B0TCJ7 Methylenetetrahydrofolate reductase n=6 Tax=Bact... 124 5e-27 UniRef50_Q60FX0 Methylenetetrahydrofolate reductase n=1 Tax=Sphi... 122 1e-26 UniRef50_B6A4H7 Methylenetetrahydrofolate reductase n=2 Tax=Rhiz... 120 5e-26 UniRef50_UPI0001698591 5,10-methylenetetrahydrofolate reductase ... 114 4e-24 UniRef50_C7MDX6 Methylenetetrahydrofolate reductase n=1 Tax=Brac... 114 4e-24 UniRef50_UPI00019055D0 5,10-methylenetetrahydrofolate reductase ... 112 1e-23 UniRef50_C9KNQ4 Methylenetetrahydrofolate reductase n=1 Tax=Mits... 111 3e-23 Sequences not found previously or not previously below threshold: UniRef50_B9L045 Methylenetetrahydrofolate reductase n=1 Tax=Ther... 201 2e-50 UniRef50_B9MN09 Methylenetetrahydrofolate reductase n=2 Tax=root... 192 1e-47 UniRef50_A8ZTK4 Methylenetetrahydrofolate reductase n=24 Tax=Bac... 188 2e-46 UniRef50_D0LSQ2 Methylenetetrahydrofolate reductase n=1 Tax=Hali... 181 2e-44 UniRef50_A9FZY9 Methylenetetrahydrofolate reductase n=1 Tax=Sora... 178 2e-43 UniRef50_D1N227 Methylenetetrahydrofolate reductase n=1 Tax=Vict... 178 2e-43 UniRef50_B8FFJ4 Methylenetetrahydrofolate reductase n=4 Tax=Bact... 177 5e-43 UniRef50_C6VPC5 Methylenetetrahydrofolate reductase n=3 Tax=Lact... 171 2e-41 UniRef50_A9QPD6 Methylenetetrahydrofolate reductase n=1 Tax=Meth... 169 8e-41 UniRef50_A1AKP7 Methylenetetrahydrofolate reductase n=10 Tax=Des... 169 8e-41 UniRef50_C4Z117 Methylenetetrahydrofolate reductase n=1 Tax=Euba... 167 5e-40 UniRef50_B1HTR8 Methylenetetrahydrofolate reductase n=95 Tax=Bac... 166 7e-40 UniRef50_C6D4G9 Methylenetetrahydrofolate reductase n=12 Tax=cel... 164 3e-39 UniRef50_O06745 5,10-methylenetetrahydrofolate reductase n=78 Ta... 164 4e-39 UniRef50_C5RGW2 Methylenetetrahydrofolate reductase n=1 Tax=Clos... 164 4e-39 UniRef50_A8SPV0 Methylenetetrahydrofolate reductase n=2 Tax=Clos... 162 1e-38 UniRef50_A9BD12 Methylenetetrahydrofolate reductase n=2 Tax=Proc... 161 3e-38 UniRef50_A3EWD2 Methylenetetrahydrofolate reductase n=2 Tax=Lept... 160 6e-38 UniRef50_B8CZI6 Methylenetetrahydrofolate reductase n=1 Tax=Halo... 159 1e-37 UniRef50_Q39WH6 Methylenetetrahydrofolate reductase n=4 Tax=Geob... 158 3e-37 UniRef50_C8WWX3 Methylenetetrahydrofolate reductase n=2 Tax=Alic... 158 3e-37 UniRef50_C0EVI7 Methylenetetrahydrofolate reductase n=1 Tax=Euba... 157 4e-37 UniRef50_C6HTS1 Methylenetetrahydrofolate reductase n=1 Tax=Lept... 156 1e-36 UniRef50_A5N923 Methylenetetrahydrofolate reductase n=2 Tax=Clos... 154 3e-36 UniRef50_Q8DUN2 Methylenetetrahydrofolate reductase n=12 Tax=Str... 154 5e-36 UniRef50_B8I637 Methylenetetrahydrofolate reductase n=2 Tax=Clos... 153 6e-36 UniRef50_B9JGE7 Methylenetetrahydrofolate reductase n=3 Tax=Rhiz... 152 1e-35 UniRef50_A6UAD8 Methylenetetrahydrofolate reductase n=11 Tax=Pro... 149 7e-35 UniRef50_C7LX76 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 149 8e-35 UniRef50_B3TCN7 Methylenetetrahydrofolate reductase n=1 Tax=uncu... 146 7e-34 UniRef50_UPI0001BCEC92 bifunctional homocysteine S-methyltransfe... 144 5e-33 UniRef50_B5YA71 Methylenetetrahydrofolate reductase n=2 Tax=Dict... 141 3e-32 UniRef50_B8FJ30 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 138 2e-31 UniRef50_Q64DN7 5-10-methylenetetrahydrofolate reductase n=3 Tax... 125 2e-27 UniRef50_C0QIT4 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 124 3e-27 UniRef50_B9KC45 Methylenetetrahydrofolate reductase n=6 Tax=Ther... 122 9e-27 UniRef50_Q7M8S8 Methylenetetrahydrofolate reductase n=1 Tax=Woli... 119 2e-25 UniRef50_A9G9E1 Methylenetetrahydrofolate reductase n=1 Tax=Sora... 118 2e-25 UniRef50_C0QE80 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 118 3e-25 UniRef50_B9L912 Methylenetetrahydrofolate reductase n=1 Tax=Naut... 118 3e-25 UniRef50_A6Q7Z1 Methylenetetrahydrofolate reductase n=4 Tax=Epsi... 117 3e-25 UniRef50_Q9HJI8 5, 10-methylenetetrahydrofolate reductase relate... 117 6e-25 UniRef50_C8R0R0 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 116 1e-24 UniRef50_Q18JC7 5,10-methylenetetrahydrofolate reductase n=2 Tax... 113 6e-24 UniRef50_A6DEC7 Methylenetetrahydrofolate reductase n=1 Tax=Cami... 110 5e-23 UniRef50_A7HND8 Methylenetetrahydrofolate reductase n=1 Tax=Ferv... 110 5e-23 UniRef50_A8A9S7 Methylenetetrahydrofolate reductase n=1 Tax=Igni... 109 8e-23 UniRef50_C3XLP8 Methylenetetrahydrofolate reductase n=1 Tax=Heli... 107 4e-22 UniRef50_C7MZV4 Methylenetetrahydrofolate reductase n=1 Tax=Sacc... 107 6e-22 UniRef50_Q9EYI8 Methylenetetrahydrofolate reductase n=2 Tax=Acti... 106 9e-22 UniRef50_B1ZRF7 Methylenetetrahydrofolate reductase n=2 Tax=Verr... 106 1e-21 UniRef50_C4DNM1 Methylenetetrahydrofolate reductase n=1 Tax=Stac... 106 1e-21 UniRef50_B0VPR6 Methylenetetrahydrofolate reductase n=15 Tax=Aci... 104 3e-21 UniRef50_D0XP42 Methylenetetrahydrofolate reductase n=1 Tax=Brev... 104 4e-21 UniRef50_C5F201 Methylenetetrahydrofolate reductase n=2 Tax=Heli... 103 7e-21 UniRef50_A4FL79 Methylenetetrahydrofolate reductase n=1 Tax=Sacc... 101 2e-20 UniRef50_Q251W5 Methylenetetrahydrofolate reductase n=3 Tax=Bact... 101 4e-20 UniRef50_C0QKT3 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 100 8e-20 UniRef50_A6DQ26 Methylenetetrahydrofolate reductase n=1 Tax=Lent... 99 2e-19 UniRef50_UPI0001C31E0D methylenetetrahydrofolate reductase n=1 T... 99 2e-19 UniRef50_A0L7S2 Methylenetetrahydrofolate reductase n=2 Tax=cell... 98 3e-19 UniRef50_A0JQZ4 Methylenetetrahydrofolate reductase n=1 Tax=Arth... 97 6e-19 UniRef50_Q3BYU2 Methylenetetrahydrofolate reductase n=16 Tax=cel... 96 1e-18 UniRef50_B9KZH8 Methylenetetrahydrofolate reductase n=2 Tax=Ther... 96 1e-18 UniRef50_Q2G4C7 Methylenetetrahydrofolate reductase n=1 Tax=Novo... 96 1e-18 UniRef50_A5EXW9 Methylenetetrahydrofolate reductase n=1 Tax=Dich... 94 3e-18 UniRef50_D1B0C6 Methylenetetrahydrofolate reductase n=1 Tax=Sulf... 94 6e-18 UniRef50_C0QY90 Methylenetetrahydrofolate reductase n=2 Tax=Brac... 91 3e-17 UniRef50_A8TJJ1 MetFprotein-like protein n=2 Tax=Bacteria RepID=... 91 6e-17 UniRef50_D2S7Q5 Methylenetetrahydrofolate reductase n=1 Tax=Geod... 89 2e-16 UniRef50_B9KUP2 Methylenetetrahydrofolate reductase n=1 Tax=Rhod... 88 3e-16 UniRef50_B6BQ92 Methylenetetrahydrofolate reductase n=2 Tax=Bact... 86 2e-15 UniRef50_B1L3C6 Methylenetetrahydrofolate reductase n=1 Tax=Cand... 85 2e-15 UniRef50_C9YXB3 Putative uncharacterized protein n=2 Tax=Actinom... 85 3e-15 UniRef50_C7JBE9 Methylenetetrahydrofolate reductase n=10 Tax=Ace... 84 5e-15 UniRef50_C8N7U0 Methylenetetrahydrofolate reductase n=1 Tax=Card... 84 6e-15 UniRef50_A9CIN8 Methylenetetrahydrofolate reductase n=2 Tax=Rhiz... 84 7e-15 UniRef50_Q7VHW2 Methylenetetrahydrofolate reductase n=3 Tax=Heli... 83 8e-15 UniRef50_Q1AXZ5 Methylenetetrahydrofolate reductase n=2 Tax=Rubr... 83 1e-14 >UniRef50_P71319 5,10-methylenetetrahydrofolate reductase n=247 Tax=Proteobacteria RepID=METF_PECCC Length = 298 Score = 424 bits (1092), Expect = e-117, Method: Composition-based stats. Identities = 252/296 (85%), Positives = 279/296 (94%) Query: 1 MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY 60 MSFFHA+QR+ALNQSLAE+QG+INVSFEFFPPRTS+ME+TLW+SIDRLSSLKPKFVSVTY Sbjct: 1 MSFFHANQREALNQSLAELQGRINVSFEFFPPRTSDMEETLWSSIDRLSSLKPKFVSVTY 60 Query: 61 GANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD 120 GANSGERDRTHSIIK IK+RTGLEAAPHLTCIDA+ ++LR IA+DYW +GIRHIVALRGD Sbjct: 61 GANSGERDRTHSIIKTIKERTGLEAAPHLTCIDASREQLREIAQDYWESGIRHIVALRGD 120 Query: 121 LPPGSGKPEMYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRA 180 LP GKP+MYA+DLV+LLKEV DFDISVAAYPEVHPEAKSAQADL+NLK K+DAGANRA Sbjct: 121 LPQEGGKPDMYAADLVSLLKEVGDFDISVAAYPEVHPEAKSAQADLINLKHKIDAGANRA 180 Query: 181 ITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFD 240 ITQFFFDVESYLRFRDRCV+ GIDVEI+PGILPVSNFKQ +KFA MTNVR+P WM MFD Sbjct: 181 ITQFFFDVESYLRFRDRCVATGIDVEIVPGILPVSNFKQLQKFATMTNVRVPNWMTTMFD 240 Query: 241 GLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 GLD+D ETRK+VGA+IAMDMVKILSREGVKDFHFYTLNRAE+SYAICHTLGVRP + Sbjct: 241 GLDNDPETRKMVGASIAMDMVKILSREGVKDFHFYTLNRAELSYAICHTLGVRPDV 296 >UniRef50_B7VLL7 Methylenetetrahydrofolate reductase n=16 Tax=Proteobacteria RepID=B7VLL7_VIBSL Length = 337 Score = 403 bits (1037), Expect = e-111, Method: Composition-based stats. Identities = 225/296 (76%), Positives = 259/296 (87%) Query: 1 MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY 60 M + HAS DALNQ++AE+ INVSFEFFPP + +ME+TLWNS+ RL +L+PKFVSVTY Sbjct: 39 MGYTHASHIDALNQNIAELSDNINVSFEFFPPSSEKMEETLWNSVHRLKTLQPKFVSVTY 98 Query: 61 GANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD 120 GANSGERDRTHSIIK IK++TGL AAPHLTCIDA+ +EL IA DYW NGI IVALRGD Sbjct: 99 GANSGERDRTHSIIKEIKNQTGLVAAPHLTCIDASREELIQIADDYWANGIESIVALRGD 158 Query: 121 LPPGSGKPEMYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRA 180 +P G G P+MYASDLV LLK DFDISVAA+PEVHPEAKSAQ+DL+NLKRKVDAGANRA Sbjct: 159 IPAGGGAPDMYASDLVELLKSRHDFDISVAAFPEVHPEAKSAQSDLINLKRKVDAGANRA 218 Query: 181 ITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFD 240 ITQFFFDVESYLRFRDRCV+AG+DVEI+PGILPVSNFKQA +FA M NV++P WMA+ F+ Sbjct: 219 ITQFFFDVESYLRFRDRCVAAGVDVEIVPGILPVSNFKQASRFAAMNNVKVPGWMAKQFE 278 Query: 241 GLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 GLDDD TR+LVGA+ A+DMV+ LSREGVKDFHFYTLNRAEM+YA+CHTLGVRP + Sbjct: 279 GLDDDPTTRQLVGASQAIDMVRTLSREGVKDFHFYTLNRAEMTYALCHTLGVRPQV 334 >UniRef50_O67422 5,10-methylenetetrahydrofolate reductase n=9 Tax=Bacteria RepID=METF_AQUAE Length = 296 Score = 379 bits (973), Expect = e-104, Method: Composition-based stats. Identities = 119/279 (42%), Positives = 170/279 (60%), Gaps = 8/279 (2%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 +G ++SFEFFPP+T E E+ L+ +I +L L P FVSVTYGA RDRT +I++ I + Sbjct: 9 KGVFSISFEFFPPKTEEGERQLFETIRKLEKLNPTFVSVTYGAGGSTRDRTRNIVQKIHE 68 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE------MYAS 133 T L HLTCI T +EL I +DY N GI +I+ALRGD+P YA Sbjct: 69 ETNLTVMAHLTCIAHTREELIDILQDYKNIGIENILALRGDVPRDKPDWRPPKGACKYAK 128 Query: 134 DLVTLLK-EVAD-FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESY 191 +LV L++ E D F I VA+YPE HPE+ + + ++ K KV+AGA+ +ITQ FF + Y Sbjct: 129 ELVELIRKEFGDWFSIGVASYPEGHPESPNLEWEVKYFKEKVEAGADFSITQMFFVNDYY 188 Query: 192 LRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKL 251 RF + C +AGID+ IIPGI+P++NFKQ +KFA + IP + + + ++D E K Sbjct: 189 YRFVEMCKNAGIDISIIPGIMPITNFKQIRKFASLCGATIPQSLIEKLEKVEDKPEEVKK 248 Query: 252 VGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 +G A++ L GV HFYTLN+++ + I + Sbjct: 249 IGIEFAINQCLDLIEHGVPGLHFYTLNKSDATLKIYEAI 287 >UniRef50_Q0CXY7 Methylenetetrahydrofolate reductase n=18 Tax=Dikarya RepID=Q0CXY7_ASPTN Length = 619 Score = 367 bits (943), Expect = e-100, Method: Composition-based stats. Identities = 97/300 (32%), Positives = 159/300 (53%), Gaps = 12/300 (4%) Query: 4 FHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN 63 H S++ A N E G+ +SFEFFPP+T++ Q L++ +DR+ +L P F+ +T+GA Sbjct: 1 MHISEKLAQN----EAAGRPGISFEFFPPKTAQGVQNLYDRMDRMHALGPSFIDITWGAG 56 Query: 64 SGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP 123 D T ++ + GLE HLTC D +++ + + G +I+ALRGD P Sbjct: 57 GRLSDLTCEMVNVAQSVYGLETCMHLTCTDMPLEKVDAALQSAYKAGCTNILALRGDPPR 116 Query: 124 GSGKPEM------YASDLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDA 175 K E YA DLV +++ FDI V YPE + + +LK KVDA Sbjct: 117 EKEKWEATDGGFRYAKDLVKYIRDKYGNHFDIGVGGYPEGADDNPDVDLLIDHLKEKVDA 176 Query: 176 GANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWM 235 G++ +TQ F+D ++++ + +C + GI+V IIPGI+P+ + + A+ T +RIP Sbjct: 177 GSSFIVTQMFYDTDNFINWVKKCRAKGINVPIIPGIMPIQTYAAFMRRANWTKIRIPPEW 236 Query: 236 AQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPG 295 + + + +D K +G + DM + L G+ HFYT+N A+ + + L + P Sbjct: 237 LEALEPVKNDDAAVKEIGKGLIADMCRRLLAAGINHLHFYTMNLAQSTQLVLEELNLTPS 296 >UniRef50_Q9SE60 Methylenetetrahydrofolate reductase 1 n=8 Tax=Viridiplantae RepID=MTHR1_ARATH Length = 592 Score = 362 bits (929), Expect = 1e-98, Method: Composition-based stats. Identities = 102/290 (35%), Positives = 154/290 (53%), Gaps = 17/290 (5%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 QGQ SFEFFPP+T + + L+ +DRL S P F +T+GA D T I +++ Sbjct: 13 QGQTAFSFEFFPPKTEDGVENLFERMDRLVSYGPTFCDITWGAGGSTADLTLEIASRMQN 72 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYAS 133 +E HLTC + +++ +NGI++++ALRGD P G K A Sbjct: 73 VICVETMMHLTCTNMPIEKIDHALETIRSNGIQNVLALRGDPPHGQDKFVQVEGGFACAL 132 Query: 134 DLVTLLKEVAD--FDISVAAYPEVHPEA---------KSAQADLLNLKRKVDAGANRAIT 182 DLV ++ F I+VA YPE HP+ +S Q+DL LK+KVDAGA+ +T Sbjct: 133 DLVNHIRSKYGDYFGITVAGYPEAHPDVIEADGLATPESYQSDLAYLKKKVDAGADLIVT 192 Query: 183 QFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGL 242 Q F+D + +L+F + C GI+ I+PGI+P+SN+K + A +IPA + + + Sbjct: 193 QLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCKTKIPAELTAALEPI 252 Query: 243 DDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 D+ E K G + A +M K + G+ H YTLN + + I LG+ Sbjct: 253 KDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDKSAIGILMNLGL 302 >UniRef50_B9HG95 Methylenetetrahydrofolate reductase n=6 Tax=rosids RepID=B9HG95_POPTR Length = 608 Score = 362 bits (929), Expect = 1e-98, Method: Composition-based stats. Identities = 95/290 (32%), Positives = 151/290 (52%), Gaps = 17/290 (5%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 ++ SFEFFPP+T + L+ +DR+ + P F +T+GA D T I +++ Sbjct: 27 SNKVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADLTLDIANKMQN 86 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYAS 133 +E HLTC + +++ +NGI++++ALRGD P G K A Sbjct: 87 IICVETMMHLTCTNMPVEKIDHALETIKSNGIQNVLALRGDPPHGQDKFVQIQGGFACAL 146 Query: 134 DLVTLLKEVAD--FDISVAAYPEVHPEA---------KSAQADLLNLKRKVDAGANRAIT 182 DLV ++ F I+VA YPE HP+A + Q DL LK+KVDAGA+ +T Sbjct: 147 DLVKHIRSKYGDYFGITVAGYPEAHPDAIGSDGFATPEDYQKDLAYLKQKVDAGADLIVT 206 Query: 183 QFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGL 242 Q F+D + +L+F + C GI I+PGI+P++N+K + +IPA + + + Sbjct: 207 QLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCKTKIPAEVTAALEPI 266 Query: 243 DDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 D+ E + G ++ +M K + G+K H YTLN + + AI LG+ Sbjct: 267 KDNEEAVRAYGIHLGTEMCKKILAHGIKTLHLYTLNMEKSALAILMNLGL 316 >UniRef50_B2IJ01 Methylenetetrahydrofolate reductase n=5 Tax=Alphaproteobacteria RepID=B2IJ01_BEII9 Length = 309 Score = 361 bits (928), Expect = 1e-98, Method: Composition-based stats. Identities = 150/300 (50%), Positives = 204/300 (68%), Gaps = 7/300 (2%) Query: 4 FHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN 63 D+ ++ ++VSFEFFPP+T ME TLW SI+RL+ L+P FVSVTYGA Sbjct: 5 MTLQSIDSSPRASRGTCEGMSVSFEFFPPKTEAMEATLWESINRLAPLQPSFVSVTYGAG 64 Query: 64 SGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP 123 R+RTH+ + I T ++ A HLTC+ A+ E+ +A+ YW G+RHIVALRGD Sbjct: 65 GSTRERTHATVARIVKETPIKPAAHLTCVAASCAEVDAVAKAYWEAGVRHIVALRGDPLE 124 Query: 124 GSG-----KPEMYA--SDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAG 176 G G P+ YA +DLV L+++ADF+ISV+AYPE HPE+ S ++DL L+ K+DAG Sbjct: 125 GIGTAFHPHPQGYAHSTDLVAGLRKIADFEISVSAYPEKHPESASIESDLDVLQAKIDAG 184 Query: 177 ANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMA 236 A RAITQFFF+ ++YLR+ D+ + GI + I+PGI+PV NFKQ FA IP W+A Sbjct: 185 ATRAITQFFFENDTYLRYLDKVRARGITIPILPGIVPVQNFKQTANFAKKAGASIPPWLA 244 Query: 237 QMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 + F+GLDDD +TR+L+ A +A + V L GV+DFHFYT+NRA++ YAICH LG+RP L Sbjct: 245 ERFEGLDDDPQTRRLIAATVAAEQVLDLVDRGVRDFHFYTMNRADLVYAICHLLGLRPKL 304 >UniRef50_A6C2T8 Methylenetetrahydrofolate reductase n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C2T8_9PLAN Length = 297 Score = 358 bits (919), Expect = 1e-97, Method: Composition-based stats. Identities = 105/278 (37%), Positives = 157/278 (56%), Gaps = 7/278 (2%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 G +S E FPPR + L+ +++ L +P FVS TYGA RT + I+++ Sbjct: 10 GTFGLSVEIFPPRNESGDAELFKTLEELVRYQPAFVSCTYGAGGSTSKRTIELCALIQNQ 69 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE------MYASD 134 A H TC+++T +EL ++ + GI +I+ALRGD P G YA++ Sbjct: 70 LHNTATAHFTCVNSTREELVEWLQNAVDAGITNIMALRGDPPAGQETFVPADGGLKYANE 129 Query: 135 LVTLLKE-VADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLR 193 LV+L+++ D I VA YPE HPEA A+ DL NLKRKVDAGA+ TQ FF+ E + + Sbjct: 130 LVSLIRKHFPDMGIGVAGYPECHPEASDAEVDLTNLKRKVDAGADAIYTQLFFNNEHFYQ 189 Query: 194 FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVG 253 FR+RC+ AGID I+PGI+P++ +++ ++ M + PA + + DD E + +G Sbjct: 190 FRERCLKAGIDRPIVPGIMPITEYRRIQRIMSMCSSEFPADLVGQLEAAQDDLEAQFEIG 249 Query: 254 ANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 A+ + L +EGV HFY LNR++ I LG Sbjct: 250 VEYAIRQCEQLIKEGVPGIHFYVLNRSQACKRIFDALG 287 >UniRef50_O80585 Methylenetetrahydrofolate reductase 2 n=14 Tax=Eukaryota RepID=MTHR2_ARATH Length = 594 Score = 357 bits (917), Expect = 3e-97, Method: Composition-based stats. Identities = 98/296 (33%), Positives = 158/296 (53%), Gaps = 18/296 (6%) Query: 14 QSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSI 73 QSLA+ +G+ SFEFFPP+T + L+ +DR+ + P F +T+GA D T I Sbjct: 8 QSLAD-EGKTAFSFEFFPPKTEDGVDNLFERMDRMVAYGPTFCDITWGAGGSTADLTLDI 66 Query: 74 IKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP----- 128 +++ +E+ HLTC + +++ +NGI++++ALRGD P G K Sbjct: 67 ASRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQDKFVQVEG 126 Query: 129 -EMYASDLVTLLKEVAD--FDISVAAYPEVHPE---------AKSAQADLLNLKRKVDAG 176 A DLV ++ F I+VA YPE HP+ ++ Q+DL LK+K+DAG Sbjct: 127 GFDCALDLVNHIRSKYGDYFGITVAGYPEAHPDVIGENGLASNEAYQSDLEYLKKKIDAG 186 Query: 177 ANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMA 236 A+ +TQ F+D + +L+F + C GI I+PGI+P++N++ + +IP + Sbjct: 187 ADLIVTQLFYDTDIFLKFVNDCRQIGISCPIVPGIMPINNYRGFLRMTGFCKTKIPVEVM 246 Query: 237 QMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 + + D+ E K G ++ +M K + GVK H YTLN + + AI LG+ Sbjct: 247 AALEPIKDNEEAVKAYGIHLGTEMCKKMLAHGVKSLHLYTLNMEKSALAILMNLGM 302 >UniRef50_Q3SVZ0 Methylenetetrahydrofolate reductase n=69 Tax=Proteobacteria RepID=Q3SVZ0_NITWN Length = 343 Score = 354 bits (908), Expect = 2e-96, Method: Composition-based stats. Identities = 146/281 (51%), Positives = 187/281 (66%), Gaps = 8/281 (2%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + +SFEFFPP+T EME+ LW +I RL+ L P FVSVTYGA R+RTHS I I T Sbjct: 56 RPTISFEFFPPKTEEMERNLWGTITRLAPLDPSFVSVTYGAGGSTRERTHSTIARILSDT 115 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG-----KPEMY--ASD 134 L A HLTC+ A E+ I Y + G+RHIVALRGD P G G PE Y ++D Sbjct: 116 RLRPAAHLTCVGAPRGEIDEIVSRYRDIGVRHIVALRGDPPGGIGTAYSTHPEGYRTSAD 175 Query: 135 LVTLL-KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLR 193 LV + + D +ISV+AYPE HPE+ D+ LK KVDAGA RAITQ FFD YLR Sbjct: 176 LVAGIKRRHGDIEISVSAYPEKHPESPDIDTDIDVLKAKVDAGATRAITQVFFDNNLYLR 235 Query: 194 FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVG 253 + DR + GID+ I+PGI+P+ NFKQA+ F +PAW+A+ F+GLD+D ETRKL+ Sbjct: 236 YLDRVRARGIDIPIVPGIMPMHNFKQARAFVTKAGTTVPAWLAEKFEGLDEDPETRKLIA 295 Query: 254 ANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRP 294 A +A V+ L++ GV FHFYT+NRA++ +AICH LG+RP Sbjct: 296 ATVAAGQVQKLAKRGVDTFHFYTMNRADLVFAICHLLGIRP 336 >UniRef50_Q89B13 5,10-methylenetetrahydrofolate reductase n=74 Tax=Proteobacteria RepID=METF_BUCBP Length = 295 Score = 352 bits (904), Expect = 9e-96, Method: Composition-based stats. Identities = 159/291 (54%), Positives = 219/291 (75%), Gaps = 1/291 (0%) Query: 1 MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY 60 M + + + LNQ L + ++N+SFEFFPP E+ LW ID+L L PKF SVT+ Sbjct: 1 MKLVYKNYHETLNQHLMNICEKVNISFEFFPPNNILSEKNLWQVIDKLKLLTPKFFSVTH 60 Query: 61 GANSGERDR-THSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRG 119 G NS R T +I+K IK TG+E PHLTCI++T +EL+ IA+ YW++GIRHI+ALRG Sbjct: 61 GTNSKIRATCTSNIVKKIKKYTGIETVPHLTCINSTEEELKVIAKTYWDSGIRHILALRG 120 Query: 120 DLPPGSGKPEMYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANR 179 D+ + KP++YA DL+ LLK +A+F+ISVAAYPEVHPEA +A+ D++NLKRKV+AGA R Sbjct: 121 DIFNTNCKPKIYAVDLIKLLKSIANFEISVAAYPEVHPEAVNAKYDIINLKRKVEAGATR 180 Query: 180 AITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMF 239 AITQFFF+++ +LRFRD CV I ++I+PGI P+SNFKQ KF+ ++NV IP W+ MF Sbjct: 181 AITQFFFNIDCFLRFRDLCVKNNITIDIVPGIFPISNFKQLLKFSSVSNVSIPKWLCCMF 240 Query: 240 DGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 GLD+D T +++G++IA+DMVK+L EG++ FHFYTLN++E+S+AIC L Sbjct: 241 HGLDNDLNTSRIIGSSIAIDMVKVLYSEGIRSFHFYTLNKSEISFAICKIL 291 >UniRef50_Q2ILB5 Methylenetetrahydrofolate reductase n=15 Tax=Bacteria RepID=Q2ILB5_ANADE Length = 300 Score = 352 bits (904), Expect = 9e-96, Method: Composition-based stats. Identities = 100/285 (35%), Positives = 155/285 (54%), Gaps = 9/285 (3%) Query: 15 SLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSII 74 A +G+ SFEFFPP+T + + L+ +++ L L P +VSVTYGA R +T ++ Sbjct: 8 RFARERGEPIFSFEFFPPKTDDGVRGLFETVEALRPLGPAYVSVTYGAGGSTRAKTIDLV 67 Query: 75 KGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------ 128 K +K +EA H+TC+ A+ +E+ + + + GI++++ALRGD P G Sbjct: 68 KRLKRDAEVEAMAHVTCVGASREEIAAVLDEVADAGIQNVLALRGDAPRGQSAFVPHPDG 127 Query: 129 EMYASDLVTLLK---EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFF 185 +AS+LV ++ E F + AAYPE H E + DL NLK KV+AG + +TQ F Sbjct: 128 FTHASELVAFIRSRPERWRFCVGAAAYPEGHVETRDLAQDLRNLKLKVEAGTDFLVTQLF 187 Query: 186 FDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDD 245 F+ Y RF +R +AG++V ++PGI+P +N +Q ++F M IP + + D Sbjct: 188 FENAHYFRFVERARAAGVEVPVVPGIMPFTNVEQVERFTAMCGAAIPPPLRAAMEVRRAD 247 Query: 246 AETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + + +G A L R G HFYTLNR+ + AI L Sbjct: 248 PDGARELGVAYATLQCADLLRRGAPGIHFYTLNRSPSTRAIVAAL 292 >UniRef50_Q3A3T2 Methylenetetrahydrofolate reductase n=20 Tax=Bacteria RepID=Q3A3T2_PELCD Length = 301 Score = 350 bits (899), Expect = 3e-95, Method: Composition-based stats. Identities = 103/288 (35%), Positives = 158/288 (54%), Gaps = 16/288 (5%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + SFEFFPP+T + + L+ +I +L SL P F SVTYGA R+RTH ++ I + + Sbjct: 11 ETTFSFEFFPPKTDKAAERLYETIRQLESLHPHFTSVTYGAGGSTRERTHDLVMRIHESS 70 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM------YASDL 135 L+ PHLTC+ + E+ I + Y GI +I+AL GD PP + +A+DL Sbjct: 71 SLDPIPHLTCVSSPEQEIHQILKRYAEAGISNILALAGDPPPDMPHYDRSQDAFPHAADL 130 Query: 136 VTLLKEVAD---------FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFF 186 V +++ D F I VA +PE HP + ++ LK KVD GA+ TQ FF Sbjct: 131 VRFIRKFNDEGLHPDKRGFGIGVAGFPEGHPTTPNRLLEMDYLKAKVDEGADYICTQLFF 190 Query: 187 DVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADM-TNVRIPAWMAQMFDGLDDD 245 D + FR+RC AGI + II GI+P+++ + K+ A++ R PA + + D DD Sbjct: 191 DNRDFYDFRERCELAGISIPIIAGIMPIASVEGMKRMAELAAGARFPAPLLRAVDRCQDD 250 Query: 246 AETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 E+ + +G + A + + L V+ HFYTLN ++ + I LG++ Sbjct: 251 PESVRRIGIHWATEQCRDLLDNEVRGIHFYTLNNSDATRQIFQCLGLQ 298 >UniRef50_B2UQZ6 Methylenetetrahydrofolate reductase n=3 Tax=Verrucomicrobia RepID=B2UQZ6_AKKM8 Length = 311 Score = 350 bits (898), Expect = 4e-95, Method: Composition-based stats. Identities = 98/290 (33%), Positives = 150/290 (51%), Gaps = 16/290 (5%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 ++SFEFFPP+ + L+ +I L +P FVSVTYGA R+ T ++ I+ + Sbjct: 13 PSLSFEFFPPKNEQAASALYQTIRELEPYRPSFVSVTYGAGGSTRELTREVVLRIQHESR 72 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYASDLV 136 + PHLTC+ + +E+ I Y G+R ++ALRGD P G+ +A+DLV Sbjct: 73 IPTVPHLTCVGHSREEVWNILDQYARAGVRAVLALRGDPPRGAKDYNRDADVFRHAADLV 132 Query: 137 TLLKEVA---------DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFD 187 T ++E F I VA +PE HP + ++ LK KVDAGA+ TQ FFD Sbjct: 133 TFIREYNESGRHPDPDGFAIGVAGFPEGHPATPNRLREMDFLKAKVDAGADYICTQLFFD 192 Query: 188 VESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMT-NVRIPAWMAQMFDGLDDDA 246 S+L +R+RC+ AGI V I+ GI+PV++ + A+++ PA + + + Sbjct: 193 NHSFLDYRERCLLAGIKVPILAGIMPVTSLSGMNRMAELSGGTCFPARLLKALKRAGSNP 252 Query: 247 ETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 + + VG A L V HFYTLN++ + I LG++ L Sbjct: 253 DAIQEVGIQYASSQCAELLDSDVDGIHFYTLNQSRATREIYRNLGLKDSL 302 >UniRef50_A1WXM6 Methylenetetrahydrofolate reductase n=221 Tax=Bacteria RepID=A1WXM6_HALHL Length = 304 Score = 349 bits (896), Expect = 7e-95, Method: Composition-based stats. Identities = 116/277 (41%), Positives = 163/277 (58%), Gaps = 6/277 (2%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 SFEFFPP+T E + L + +RL L P + SVT+GA +DRT + I+ + Sbjct: 9 RVFSFEFFPPKTDEGAENLKGTRERLERLNPAYFSVTFGAGGSTQDRTFETVIDIQRNST 68 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK----PEMYASDLVTL 138 +AAPHL+CIDA+ D L+ + DY G+++IVALRGD P GSG YA++LV L Sbjct: 69 ADAAPHLSCIDASRDRLKQMILDYKEQGVKYIVALRGDRPSGSGSMGQGELSYANELVEL 128 Query: 139 LKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRD 196 ++EV F I V AYPE HPEA A D+ N RK AGA+ AITQFF++ + Y RF + Sbjct: 129 IREVTGDHFYIEVGAYPEFHPEAPDALTDIENFVRKAKAGADSAITQFFYNADCYYRFVE 188 Query: 197 RCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANI 256 C G+D+ I+PGI+P+ NF+Q +FA +P W+AQ + DD ++R G ++ Sbjct: 189 DCEKRGVDIPIVPGIMPLMNFEQQARFAAACKADMPRWLAQRMEAWKDDPQSRMEYGIDV 248 Query: 257 AMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 + + L G HFY LN+A + I H LG+ Sbjct: 249 VTRLCEDLLDNGAPGIHFYALNKAPVVERIWHNLGLS 285 >UniRef50_O54235 5,10-methylenetetrahydrofolate reductase n=40 Tax=Bacteria RepID=METF_STRLI Length = 307 Score = 346 bits (888), Expect = 6e-94, Method: Composition-based stats. Identities = 109/301 (36%), Positives = 161/301 (53%), Gaps = 9/301 (2%) Query: 1 MSFFHASQRDALNQSLAEV--QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSV 58 M+ AS R +++ ++ G+ SFEF P+T + E+ LW+++ R+ ++ P FVSV Sbjct: 1 MALGTASTRTDRARTVRDILATGKTTYSFEFSAPKTPKGEKNLWSALRRVEAVAPDFVSV 60 Query: 59 TYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALR 118 TYGA R T + I T L HLT +D + ELR I Y + GIR+++A+R Sbjct: 61 TYGAGGSTRAGTVRETQQIVADTTLTPVAHLTAVDHSVAELRNIIGQYADAGIRNMLAVR 120 Query: 119 GDLPPGSG-----KPEM--YASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKR 171 GD P PE YA++LV L+KE DF + VAA+PE+HP + D+ N Sbjct: 121 GDPPGDPNADWIAHPEGLTYAAELVRLIKESGDFCVGVAAFPEMHPRSADWDTDVTNFVD 180 Query: 172 KVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRI 231 K AGA+ AITQ FF +SYLR RDR +AG +IP ++PV++ K ++ ++N Sbjct: 181 KCRAGADYAITQMFFQPDSYLRLRDRVAAAGCATPVIPEVMPVTSVKMLERLPKLSNASF 240 Query: 232 PAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 PA + + DD + +G A + L EGV HF TLN + + I LG Sbjct: 241 PAELKERILTAKDDPAAVRSIGIEFATEFCARLLAEGVPGLHFITLNNSTATLEIYENLG 300 Query: 292 V 292 + Sbjct: 301 L 301 >UniRef50_B7G287 Methylenetetrahydrofolate reductase n=3 Tax=stramenopiles RepID=B7G287_PHATR Length = 634 Score = 346 bits (887), Expect = 8e-94, Method: Composition-based stats. Identities = 95/304 (31%), Positives = 149/304 (49%), Gaps = 21/304 (6%) Query: 7 SQRDALNQSLAEVQ-----GQINVSFEFFPPRTSEMEQTLWNSIDRLSS-LKPKFVSVTY 60 D+ SL + Q G SFEFFPP+T L IDR++ L P F+ VT+ Sbjct: 18 RSNDSRQPSLHDCQLNFPGGNWYYSFEFFPPKTEAGLDNLLTRIDRMAQRLDPLFIDVTW 77 Query: 61 GANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD 120 G++ RT ++ + G++ HL+C T D+L + GI +I+ALRGD Sbjct: 78 GSD-KTSARTMALASHAQKYLGVDVLLHLSCQGMTRDQLIRVLDQAKVLGIHNILALRGD 136 Query: 121 LPPGSGKPEM---------YASDLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNL 169 P ++ A DLV L++ F I+VA +PE HP + S + +L +L Sbjct: 137 PPKAKKHWQVGDVSGGECERAIDLVRLIRNTYGDYFGIAVAGHPEGHPSSTSPEDELDHL 196 Query: 170 KRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNV 229 K K+ AGA+ I+QF +D E +L F RC GI I+PGI+P+ ++ + V Sbjct: 197 KEKMRAGADFIISQFVYDTERFLDFCYRCRDVGIQCPILPGIMPIQSYSSFTRMTQYCGV 256 Query: 230 RIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREG---VKDFHFYTLNRAEMSYAI 286 +P + + + + DD E K +G ++A +M + + + + HFYTLN + I Sbjct: 257 SVPDEIWKRLEPIKDDDEAVKEIGCSLAAEMCRQILADPIAKIDGVHFYTLNLERSATRI 316 Query: 287 CHTL 290 L Sbjct: 317 LMQL 320 >UniRef50_A0LTK4 Methylenetetrahydrofolate reductase n=19 Tax=Actinomycetales RepID=A0LTK4_ACIC1 Length = 331 Score = 345 bits (886), Expect = 9e-94, Method: Composition-based stats. Identities = 106/281 (37%), Positives = 151/281 (53%), Gaps = 7/281 (2%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 +G + SFEFFPP+T++ E+ L+ +I L L+P FVSVTYGA T I + I Sbjct: 22 RGGSSFSFEFFPPKTADGERALFQTIRALEVLRPTFVSVTYGAGGSTAAATVRITERIAT 81 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG-------KPEMYA 132 T L HLT ++ + E+R + Y G+R+I+ALRGD P YA Sbjct: 82 ETTLTPVGHLTIVNQSVAEIRRVIGQYAAAGVRNILALRGDPPGNPNGEWIPHPHGFRYA 141 Query: 133 SDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYL 192 +LV LLK V DF + VAA+P HP + + + D K AGA+ AITQ FF VE YL Sbjct: 142 VELVRLLKMVGDFCVGVAAFPRKHPRSPTLEDDTRYFVEKCRAGADFAITQMFFRVEDYL 201 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV 252 R R+R AG V IIPG++P+++ Q ++FA ++ P +A + D + + Sbjct: 202 RLRERIERAGCTVPIIPGVMPITSIGQIERFALLSGDEFPPELADRILAVADQPAAVRAI 261 Query: 253 GANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 G +A +M + L EG HFYTLNR+ + I L + Sbjct: 262 GIEVATEMCRRLLDEGAPGLHFYTLNRSTATREIYQNLRLS 302 >UniRef50_C1ZF18 Methylenetetrahydrofolate reductase n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZF18_PLALI Length = 310 Score = 344 bits (882), Expect = 3e-93, Method: Composition-based stats. Identities = 97/283 (34%), Positives = 152/283 (53%), Gaps = 9/283 (3%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 GQ +S E FPP+T+E + L ++ S+ P FVS TYGA R RT + I D Sbjct: 21 SGQFALSIEIFPPKTAEGDAALRQALQEFSTYNPAFVSCTYGAGGSTRSRTLDWCREIID 80 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYAS 133 R G+ H TC+ + DEL W G+R+I+ALRGD+P G + +A Sbjct: 81 RVGVAPTAHFTCVGSNSDELIDWLGQAWQLGVRNIMALRGDVPQGETEFKAVEGGFSHAR 140 Query: 134 DLVTLLK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYL 192 LV L++ E + I VA YPE HPEA S + D+ LK K+ G + TQ F+D E++ Sbjct: 141 QLVELIRKEFPEMGIGVAGYPEKHPEAVSLETDIAFLKEKITVGGHAVFTQLFYDNETFY 200 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLD--DDAETRK 250 R+ + C+ GID IIPG++P++ + + K+ +++ ++PA + + + DD + Sbjct: 201 RYWEMCLKQGIDAPIIPGVMPITEYSRVKRIVEISGTKVPAELLEQLEAAHLRDDKAAQL 260 Query: 251 LVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 +G ++ + L GV HFY LN+A + I +LG++ Sbjct: 261 EIGIEYSVQQCQDLIDHGVPGLHFYVLNKAHATSQILQSLGLK 303 >UniRef50_Q0AYF5 Methylenetetrahydrofolate reductase n=10 Tax=Bacteria RepID=Q0AYF5_SYNWW Length = 287 Score = 343 bits (880), Expect = 4e-93, Method: Composition-based stats. Identities = 97/273 (35%), Positives = 148/273 (54%), Gaps = 3/273 (1%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG-ERDRTHSIIKGIKD 79 + +S E FPPR + ++ +++ L L P F+SVTYGA T I IK+ Sbjct: 9 NKTVLSLEIFPPRRTASIGIIYKTLEELQGLNPDFISVTYGAGGSETNTATLEIASAIKN 68 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG--SGKPEMYASDLVT 137 G+E+ HL CI+ DE+ + + G+ +I+ALRGD+ P + YASDLV+ Sbjct: 69 NYGIESVAHLPCINLNKDEVLNMLEGFKQAGVENILALRGDVNPARVPKQDFRYASDLVS 128 Query: 138 LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDR 197 +KE DF+I A YPE H E+ S D+ +LK KVDAG ++ ITQ FFD + FR+R Sbjct: 129 FIKENGDFNIIGACYPEGHSESPSLLDDIRHLKIKVDAGTDQLITQLFFDNSYFYSFRER 188 Query: 198 CVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIA 257 AGI+V I GI+PV N +Q ++ + V++P M + +++ E + G A Sbjct: 189 ASVAGINVAIEAGIMPVVNKRQIERMVALCGVKLPKKFVTMMERYENNPEAMRDAGIAYA 248 Query: 258 MDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 +D + L +GV H YT+N ++ I + Sbjct: 249 VDQIVDLIAQGVDGIHLYTMNNPYIAKKIYAAI 281 >UniRef50_D1Y625 Methylenetetrahydrofolate reductase n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y625_9BACT Length = 292 Score = 342 bits (877), Expect = 1e-92, Method: Composition-based stats. Identities = 96/271 (35%), Positives = 150/271 (55%), Gaps = 3/271 (1%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 N SFE FPP+ + +++++++D L+SL+P +SVTYGA RD T I I++R Sbjct: 10 PNFSFEIFPPKRTGSLESIYSTVDALASLRPDLISVTYGAGGSNRDNTIEIASTIQNRYL 69 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY---ASDLVTLL 139 L A HLTC+ ++ ++ + + G+R I+ALRGD + + Y A++LV + Sbjct: 70 LPAVAHLTCVGSSLEQTDALLAELKERGVRTILALRGDRRADADFEDGYFKHAAELVAHI 129 Query: 140 KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199 K+ DF + A YPE HPEA S +AD+ +LK KVDAG + ITQ F + + + RFRD Sbjct: 130 KKNYDFRVLGACYPEKHPEAPSLEADIAHLKEKVDAGVDALITQLFLNNDDFYRFRDLAQ 189 Query: 200 SAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMD 259 AG++V II GI+P++ K M IP + + D +AE + G A Sbjct: 190 KAGVNVPIIAGIMPITQASMLDKVVSMCGASIPPAVRRFVDAYGHNAEAVREAGIAYAAS 249 Query: 260 MVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + L GV+ H Y++N+A ++ I + Sbjct: 250 QIVDLLASGVEGIHIYSMNKAGVTRQIAQNI 280 >UniRef50_B5JFK7 Methylenetetrahydrofolate reductase n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JFK7_9BACT Length = 296 Score = 341 bits (876), Expect = 2e-92, Method: Composition-based stats. Identities = 102/277 (36%), Positives = 148/277 (53%), Gaps = 7/277 (2%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 + + +S EFFPP++ E L S + L+ P FVSVTYGA RDR+ + ++D Sbjct: 12 ESRPLLSVEFFPPKSDEALDELVESAEELAPYSPDFVSVTYGAGGSTRDRSAKACQLLRD 71 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYAS 133 PHLTC+ A+ EL + G R+I+ALRGD P S +AS Sbjct: 72 EHDFNIMPHLTCVGASRGELAETINGLYEAGYRNIMALRGDPPKDSNSFVVAKDGFAHAS 131 Query: 134 DLVTLLKE-VADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYL 192 DLV+ +KE D I VA YPE HPEA DL +LK KVDAGA+ TQ FFD Sbjct: 132 DLVSFIKELHPDISIGVAGYPEKHPEATDLATDLRHLKTKVDAGASFITTQLFFDNADLY 191 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV 252 RF D+ GI+V +IPG++PV + KQ K+ A + +P+ + + D+AE + + Sbjct: 192 RFLDQAADQGIEVPVIPGLMPVLSIKQIKRIASLCGASLPSELETHLNAAGDNAELVRQI 251 Query: 253 GANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHT 289 G A + ++ L +G+ H Y LNR++++ + Sbjct: 252 GVRWASEQLQDLVEQGLPGVHLYALNRSDIATELMSA 288 >UniRef50_B9XQY3 Methylenetetrahydrofolate reductase n=2 Tax=Verrucomicrobia RepID=B9XQY3_9BACT Length = 303 Score = 341 bits (875), Expect = 2e-92, Method: Composition-based stats. Identities = 104/301 (34%), Positives = 156/301 (51%), Gaps = 12/301 (3%) Query: 4 FHASQRDALNQSLAEVQG---QINVSFEFFPPRTSEMEQTLWN-SIDRLSSLKPKFVSVT 59 H Q + + + Q +SFEFFPP+T E ++ L +I L LKP F SVT Sbjct: 1 MHNRQLMQFIRDIYAAKADAHQPVISFEFFPPKTDEGDRALLEKTIPALLRLKPDFCSVT 60 Query: 60 YGANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRG 119 YGA G RD+T I+ I+ L HLTC++AT ++LR + + G+++I+ALRG Sbjct: 61 YGAGGGTRDKTLMIVDRIQREHQLPTMLHLTCVNATREQLRDVIEQARSLGVKNILALRG 120 Query: 120 DLPPGSGKP------EMYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQA-DLLNLKRK 172 D P G+G+ Y+ LV LL+E+ F I A +PE H K + D +LK+K Sbjct: 121 DPPGGNGEFKMTDGGFEYSHQLVALLRELGGFSIGTAGFPEGHIACKEGKHVDWEHLKKK 180 Query: 173 VDAGANRAITQFFFDVESYLRFRDRC-VSAGIDVEIIPGILPVSNFKQAKKFADMTNVRI 231 +D GA+ +TQ F++ Y FRD G V I PGILP+ + Q K+ + + ++ Sbjct: 181 IDCGADFVVTQLFYNNADYFEFRDHLTKKLGASVPIFPGILPILSAGQIKRISALCGAKL 240 Query: 232 PAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 P+ + + L D+ E G + A + L REG H YTLN+A + + L Sbjct: 241 PSRLVSCLEKLADNDEAAAAYGIDYATEQCAELLREGAPGLHMYTLNKAPSTIQVLKNLA 300 Query: 292 V 292 + Sbjct: 301 L 301 >UniRef50_C1SKU9 Methylenetetrahydrofolate reductase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SKU9_9BACT Length = 284 Score = 339 bits (871), Expect = 6e-92, Method: Composition-based stats. Identities = 100/279 (35%), Positives = 151/279 (54%), Gaps = 9/279 (3%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 ++ + +VSFEFFPP+ E EQ L+ +I +L P+FVSVTYGA ++T K +K Sbjct: 7 LKDKRSVSFEFFPPKKQESEQVLFETIKKLRRYNPEFVSVTYGAGGSTTEKTLEWTKRMK 66 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP-----EMYAS 133 + H TCI A + + + + + +I+ALRGD+P G+ + YA+ Sbjct: 67 EDHDYSVMMHFTCIGADAAVIDSATQSLKESRVDNILALRGDIPAGTTEFKPTKDFQYAA 126 Query: 134 DLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESY 191 DLV +++ F I VA YPE HPEA S D+ NLKRKVD GA+ ITQ FFD + Sbjct: 127 DLVRYIRKTTGDHFSIGVAGYPEKHPEAGSMAEDIDNLKRKVDEGADFIITQLFFDNFYF 186 Query: 192 LRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKL 251 + D+ AGI++ ++ GI+P+ N QA KF DM IP + + + D + + Sbjct: 187 YNYLDKVRKAGINIPVVAGIMPLVNLSQAVKFTDMCGASIPKPLLEKME--DKSLKDQFE 244 Query: 252 VGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 +G + A+ L G + HFYTLN+ ++ I + Sbjct: 245 IGLDYAVKQCGGLWESGAEGLHFYTLNKHGVTEEILKRI 283 >UniRef50_Q5FNV4 Methylenetetrahydrofolate reductase n=1 Tax=Gluconobacter oxydans RepID=Q5FNV4_GLUOX Length = 309 Score = 339 bits (870), Expect = 7e-92, Method: Composition-based stats. Identities = 136/278 (48%), Positives = 181/278 (65%), Gaps = 5/278 (1%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 +SFE PPRT MEQ LW + RL+ L P+FVSVTYGA + +T + + +K T Sbjct: 27 PVLSFEVVPPRTDAMEQRLWQCMRRLAPLSPRFVSVTYGACGTMQAQTQATVLRLKQETT 86 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG---KP--EMYASDLVT 137 L A HLTCI AT +E+ IAR YW G+RHI+ALRGD P G+ P YA DLV Sbjct: 87 LVPAAHLTCIGATREEIDDIARTYWQAGVRHILALRGDAPAGTDYTPHPGGYAYAGDLVA 146 Query: 138 LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDR 197 L+ +ADF+ISVAAYPE HP A + QAD+ NLKRK DAGA+RAITQ+FF+ + LRF DR Sbjct: 147 GLRRIADFEISVAAYPETHPTAPNPQADIDNLKRKFDAGASRAITQYFFEASTCLRFLDR 206 Query: 198 CVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIA 257 C++AGI I+PGI+PVSN+ +F+ V +P W+ +F+G + E ++ +A Sbjct: 207 CLAAGITAPIVPGIMPVSNYDHIARFSAFCGVTVPVWLTHLFEGTAKNPELCRIAACIVA 266 Query: 258 MDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPG 295 + V+ L G+ +FHF TLNR +++ AI H LGVRP Sbjct: 267 AEQVRTLQSHGINEFHFSTLNRPDLTCAIAHLLGVRPA 304 >UniRef50_C7LW31 Methylenetetrahydrofolate reductase n=2 Tax=Desulfovibrionales RepID=C7LW31_DESBD Length = 295 Score = 337 bits (864), Expect = 3e-91, Method: Composition-based stats. Identities = 97/287 (33%), Positives = 138/287 (48%), Gaps = 9/287 (3%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 + + +S EFFPP+ ++ + +L +L P F SVTYGA + T I+ +K Sbjct: 8 QRQEPFLSLEFFPPKDRAQWPGFFDVVRQLRALAPLFCSVTYGAGGSTQHNTLEIVTRMK 67 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS------GKPEMYA 132 GLE HLTC+ A L + G+ +++ALRGD P G + + Sbjct: 68 QEYGLEPLAHLTCVGADRARLGSFLSGLGEAGVDNVLALRGDPPRGETSFTPDSEEFQHG 127 Query: 133 SDLVTLLK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESY 191 SDLV+ ++ E +D I VA YPE HPEA S DL L+ KV +GA+ ITQ FFD + Y Sbjct: 128 SDLVSFIRQEFSDLCIGVAGYPEKHPEAPSMADDLERLRHKVASGADFVITQLFFDNDRY 187 Query: 192 LRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDD--DAETR 249 F R +AGI V IIPGILPV N ++ +P + + + Sbjct: 188 FDFVVRARAAGIGVPIIPGILPVQNLGALQRMLTFCGASVPEGYMRDLEHVHKVYGESGV 247 Query: 250 KLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 + +G A ++ L G H YTLN+A+ I R GL Sbjct: 248 RGLGLGYAKSQIRNLLDRGAPGVHLYTLNKADTCLDIWKDFSSRDGL 294 >UniRef50_C6NUC2 Methylenetetrahydrofolate reductase n=1 Tax=Acidithiobacillus caldus ATCC 51756 RepID=C6NUC2_9GAMM Length = 276 Score = 337 bits (864), Expect = 3e-91, Method: Composition-based stats. Identities = 108/270 (40%), Positives = 154/270 (57%), Gaps = 2/270 (0%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 S EFFPP+ E L +I L +L+P + SVTYGA ++RT + + + T LE Sbjct: 7 FSVEFFPPKNPAGEAKLRETIGALQALRPDYASVTYGAAGSTQERTLATVAMLARDTELE 66 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY--ASDLVTLLKEV 142 A PHLTCI +T +R I Y GIR IVALRGDLPP P + A DL+ ++ Sbjct: 67 AVPHLTCIGSTEAGIRAILEHYRELGIRRIVALRGDLPPDREDPGFFHQALDLIAYIRAF 126 Query: 143 ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAG 202 F I AAYPE HP A A+ADL L+RKV+AGA+ ITQ+F++ ++YL+ RD G Sbjct: 127 GGFQIYAAAYPEFHPRAVHARADLEYLQRKVEAGASGLITQYFYNPDAYLQLRDDLARRG 186 Query: 203 IDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVK 262 +DV I G++P++N+ Q F+ IP ++ + + DD + + +A + Sbjct: 187 VDVPITVGVMPMTNYAQIANFSAQCGAEIPQFLRRRMESFADDPGAQAELAIEVASRQCR 246 Query: 263 ILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 +L +G HFYTLN+AE + AI LG+ Sbjct: 247 LLLDQGAPGLHFYTLNQAEATLAIARNLGL 276 >UniRef50_Q21NJ7 Methylenetetrahydrofolate reductase n=2 Tax=Gammaproteobacteria RepID=Q21NJ7_SACD2 Length = 297 Score = 336 bits (863), Expect = 4e-91, Method: Composition-based stats. Identities = 108/280 (38%), Positives = 157/280 (56%), Gaps = 5/280 (1%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 Q + +SFEFFPP+T + L L+ + P F SVTYGA RD T I+K +++ Sbjct: 4 QQEFRLSFEFFPPKTDVGREKLITVRKELNDIHPDFFSVTYGAGGSTRDNTKGIVKKMRE 63 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE--MYASDLVT 137 GL APHL+ T + + ++Y + G+ IVALRGD+P G G + +YA++LV Sbjct: 64 E-GLNVAPHLSFGGDTEQTILPLLQEYKDMGVDRIVALRGDMPSGVGGAQQLVYANELVA 122 Query: 138 LLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFR 195 +++ D F + VAAYPE+HPEA S D+ LK K DAGAN AITQ+FF+ ++Y F Sbjct: 123 FIRKHFDDYFHLEVAAYPEIHPEATSYLDDVRYLKGKFDAGANSAITQYFFNPDAYFYFM 182 Query: 196 DRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGAN 255 D+C GID I PGI+P+ N++ +F+D IP WM + + D+ E G + Sbjct: 183 DQCQKEGIDQPIYPGIMPILNYRNLARFSDSCGADIPRWMRKRMESFGDNQEALISFGID 242 Query: 256 IAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPG 295 ++ L G HFYT+N+ E + I LG+ Sbjct: 243 WISELCDTLLDAGAPGLHFYTMNQTEPTATIIKNLGLEDA 282 >UniRef50_B6FS52 Methylenetetrahydrofolate reductase n=1 Tax=Clostridium nexile DSM 1787 RepID=B6FS52_9CLOT Length = 288 Score = 336 bits (862), Expect = 5e-91, Method: Composition-based stats. Identities = 95/275 (34%), Positives = 148/275 (53%), Gaps = 4/275 (1%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 + ++N+SFE FPP+T + + + +++LKP F+SVTYGA G T I I++ Sbjct: 9 ENRVNISFEVFPPKTDAGYGKVLEATEEIAALKPSFISVTYGAGGGTSKNTVKIASHIQN 68 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP----EMYASDL 135 G+ + HLTC +T +E+R + GI++I+ALRGD+P P YAS+L Sbjct: 69 DLGVASLAHLTCASSTKEEVRQVIEQLKEQGIQNILALRGDIPKDGAFPIPNHYKYASEL 128 Query: 136 VTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFR 195 + +K DF I A YPE H E++ D+ +LK KVD G + TQ FFD F Sbjct: 129 IADIKSQGDFCIGAACYPEGHVESEHKSEDIAHLKEKVDVGVDFLTTQMFFDNSILYNFL 188 Query: 196 DRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGAN 255 R GI V ++PGI+PV+N KQ + +++ +P + D DD + + G Sbjct: 189 YRIREKGITVPVLPGIMPVTNGKQIARICELSGTILPERFRAIVDRFGDDPKAMQQAGIA 248 Query: 256 IAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 A D + L G+++ H Y++N+ E++ AI L Sbjct: 249 YATDQIIDLIANGIQNIHIYSMNKPEIAAAIMTNL 283 >UniRef50_P53128 Methylenetetrahydrofolate reductase 2 n=42 Tax=Ascomycota RepID=MTHR2_YEAST Length = 600 Score = 336 bits (861), Expect = 7e-91, Method: Composition-based stats. Identities = 90/291 (30%), Positives = 150/291 (51%), Gaps = 13/291 (4%) Query: 17 AEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLK-PKFVSVTYGANSG-ERDRTHSII 74 + G+ SFE+F P+T++ Q L++ +DR+ P+F+ +T+ A G + ++ Sbjct: 11 RQTSGKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGGGRLSHLSTDLV 70 Query: 75 KGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------ 128 + GLE HLTC + + + +++G ++I+ALRGD P + Sbjct: 71 ATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPRDAENWTPVEGG 130 Query: 129 EMYASDLVTLLKEVAD--FDISVAAYPEVHPEAKSAQA--DLLNLKRKVDAGANRAITQF 184 YA DL+ +K F I VA YPE HPE + DL LK+K+DAG + ITQ Sbjct: 131 FQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPNKDVKLDLEYLKQKIDAGGDFIITQM 190 Query: 185 FFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDD 244 F+DV++++ + + +AG+DV IIPGI+P++ + + A + IP + D + D Sbjct: 191 FYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQWGQISIPQHFSSRLDPIKD 250 Query: 245 DAETRKLVGANIAMDMVKILSREG-VKDFHFYTLNRAEMSYAICHTLGVRP 294 D E + +G N+ ++M + L G V H YT+N + I L + P Sbjct: 251 DDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLMILERLNILP 301 >UniRef50_D2QYY6 5,10-methylenetetrahydrofolate reductase n=3 Tax=Planctomycetaceae RepID=D2QYY6_9PLAN Length = 292 Score = 334 bits (856), Expect = 3e-90, Method: Composition-based stats. Identities = 114/282 (40%), Positives = 159/282 (56%), Gaps = 8/282 (2%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 G+ +SFE FPP+T+ E ++ SI L + +P ++ TYGA RD+T I +K Sbjct: 5 PSGKRTLSFELFPPKTTAGETAMYQSIGELMAFQPDVITCTYGAGGSTRDKTLEITASVK 64 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM------YA 132 + G++ A HLTC+ +T D+LR RD + G+ +IVALRGD P G +M YA Sbjct: 65 QQFGVKVASHLTCVGSTQDQLRDYLRDAISRGVENIVALRGDPPKGETSFQMCEGGLRYA 124 Query: 133 SDLVTLLK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESY 191 SDLV L+K + + I+VA YPE H EA S DL NLKRKVDAG + ITQ F+D + Sbjct: 125 SDLVALIKADFPELGIAVAGYPETHQEAISYADDLANLKRKVDAGGDAIITQLFYDNADF 184 Query: 192 LRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKL 251 RFRD C + GI V IIPGILPV+N Q ++ + ++P+ G DD + Sbjct: 185 FRFRDDCDALGITVPIIPGILPVTNLAQIQRITSLCKAKLPSVFVAKL-GEQDDTAWQFQ 243 Query: 252 VGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 VG A V+ L GV HFY LN+++ + + +G Sbjct: 244 VGVEQATVQVQELLHAGVPGIHFYVLNKSQATSEVLRGIGWS 285 >UniRef50_A8NEV2 Methylenetetrahydrofolate reductase n=2 Tax=Agaricales RepID=A8NEV2_COPC7 Length = 617 Score = 334 bits (856), Expect = 3e-90, Method: Composition-based stats. Identities = 92/299 (30%), Positives = 152/299 (50%), Gaps = 16/299 (5%) Query: 11 ALNQSLAE-VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDR 69 L+Q +AE + +FEFFPPRT + + L I RLS+L P +S+T+GA ++R Sbjct: 2 KLSQKIAEHDPSKPFYTFEFFPPRTDQGTENLIARISRLSTLDPLAISITWGAGGSTKER 61 Query: 70 THSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP- 128 + + + + L+ HLTC + + + +D + GI I+ALRGD P G + Sbjct: 62 SLDLASITQSQHRLDTILHLTCTNMEQGLIDDVLKDVKDRGIETILALRGDPPRGEEEWI 121 Query: 129 -----EMYASDLVTLLKE----VADFDISVAAYPEVHPEAK-SAQADLLNLKRKVDAGAN 178 +A DLV ++ + F I VA + H E+ S +L +LK KVDAGA+ Sbjct: 122 PSDPRFTHAIDLVKYIRGSQEYSSHFCIGVA---DGHTESTCSEDEELEHLKAKVDAGAD 178 Query: 179 RAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQM 238 +TQ F+DV+ +L++ + + GI V IIPGI+P+ + + + ++P+ + Sbjct: 179 FIVTQLFYDVDRFLQWLKKVRAKGITVPIIPGIMPIQTYATFARLTKLCGTKVPSTLEAD 238 Query: 239 FDGLDDDAETRKLVGANIAMDMVKILSRE-GVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 + +D + K G A+ + L E G++ FHF TLN + + L R G+ Sbjct: 239 LLPIKNDDQLVKDYGVKYAVKTIHRLRNEGGIQGFHFCTLNLEKSVQRVLEELKWRTGV 297 >UniRef50_Q04NW1 Methylenetetrahydrofolate reductase n=5 Tax=Leptospira RepID=Q04NW1_LEPBJ Length = 290 Score = 332 bits (851), Expect = 1e-89, Method: Composition-based stats. Identities = 93/282 (32%), Positives = 144/282 (51%), Gaps = 7/282 (2%) Query: 16 LAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIK 75 + SFEFFPP+T + + L ++ L+ L P FV+VTYGA RD+T I+ Sbjct: 7 IYGSAKGPVYSFEFFPPKTQDGDLKLMGTVKELARLDPDFVTVTYGAGGSTRDKTAQILS 66 Query: 76 GIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------E 129 I H TC+ A D++ ++ ++GI +++ALRGD P G GK Sbjct: 67 EISKNYSFPTVSHFTCVGANQDQIFKTLKEIRSSGIVNLMALRGDPPKGEGKFKKTEGGF 126 Query: 130 MYASDLVTLLK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDV 188 A++L++ ++ E DF I YPE HP AKS + D+ NLKRKVDAG + ++Q FF Sbjct: 127 ENATELISFIRSEKLDFCIGGGCYPEKHPNAKSLEEDVRNLKRKVDAGTDFLVSQLFFVN 186 Query: 189 ESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAET 248 + F + A I +IPGI+P+++F Q ++F + P+ + + ++ E Sbjct: 187 SIFENFLNLVRKADIRAPVIPGIMPITSFSQIERFRSIAGCEFPSSLIEDLQEVEHRPEE 246 Query: 249 RKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 N ++ + L GV H YTLN++ SY I L Sbjct: 247 FYRRSLNFSIKQCRELLAMGVPGIHLYTLNQSHASYDIVREL 288 >UniRef50_D1B7X9 Methylenetetrahydrofolate reductase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B7X9_THEAS Length = 298 Score = 332 bits (851), Expect = 1e-89, Method: Composition-based stats. Identities = 99/279 (35%), Positives = 141/279 (50%), Gaps = 6/279 (2%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 +G+ +SFE FPPR + ++ ++ + L P FVSVTYGA RD T I +K+ Sbjct: 9 RGRPVISFEIFPPRGGVPVEEVYRTLGAIKDLAPDFVSVTYGAGGSTRDATLEIASTVKN 68 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM----YASDL 135 R GLE H T + TP E+ + D G+ +++A+RGD P PE + SDL Sbjct: 69 RFGLEVMAHCTGLCHTPPEVHEMVEDLMYEGVHNLLAMRGDPPRDRHVPEGPSFPHGSDL 128 Query: 136 VTLLKE-VAD-FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLR 193 + L+ D I+ AAYPE H EA+ + DL LK KVD GA ITQ FFD E + R Sbjct: 129 IGYLRRAFGDEVCIAAAAYPEGHVEARDMEEDLAFLKLKVDMGAELLITQLFFDNEIFYR 188 Query: 194 FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVG 253 F + GI V + GI PV N +Q ++ + V P +M DD + G Sbjct: 189 FLESIGRLGIRVPVCAGIFPVLNARQVERIVSLCGVSFPPKFTRMVARYADDPASLAEAG 248 Query: 254 ANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 A + + L GV H YT+NR + + I + +G+ Sbjct: 249 VAYATEQIVDLLAFGVDGIHIYTMNRPDTTRRIMNNIGL 287 >UniRef50_B9WCV3 Methylenetetrahydrofolate reductase n=10 Tax=Saccharomycetales RepID=B9WCV3_CANDC Length = 640 Score = 331 bits (850), Expect = 1e-89, Method: Composition-based stats. Identities = 83/283 (29%), Positives = 141/283 (49%), Gaps = 15/283 (5%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + VSFEFFPP+T + L ++R+S+ P F++VT+GA +++ + ++ Sbjct: 15 EKFVSFEFFPPKTDSGFRNLLARLNRMSAFNPLFITVTWGAGGSTSEKSLDLAATCQNEI 74 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP-----EMYASDLV 136 G+ HLTC + + + G+R+I+ALRGD P A DLV Sbjct: 75 GITTVLHLTCTNTNKEVIDQALSKAKAAGVRNILALRGDPPRTEEYWTPNCDFSGAVDLV 134 Query: 137 TLLKEVAD--FDISVAAYPEVHPE-----AKSAQADLLNLKRKVDAGANRAITQFFFDVE 189 ++E F I VAAYPE H + +++ Q D+ L KV AGA+ ITQ FFDVE Sbjct: 135 KYIRENYGDYFCIGVAAYPEGHVDGSDISSQNPQKDIPFLVEKVKAGADFIITQLFFDVE 194 Query: 190 SYLRFRDRCVSAG--IDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAE 247 ++ F + +IPG++P++ +K + A +++ IP + + D + D Sbjct: 195 KFIAFEKLLKEHDELKGIPLIPGLMPITTYKVFNRAAKLSHASIPRGILKQVDQVCHDDN 254 Query: 248 TRKLVGANIAMDMVKIL-SREGVKDFHFYTLNRAEMSYAICHT 289 K +G +I +++ + ++ +HFYTLN + +I Sbjct: 255 AVKALGVDILTEIIDRIDKSTNIRGYHFYTLNLEKAVASILDK 297 >UniRef50_B1ZNX1 Methylenetetrahydrofolate reductase n=2 Tax=Opitutaceae RepID=B1ZNX1_OPITP Length = 292 Score = 331 bits (848), Expect = 2e-89, Method: Composition-based stats. Identities = 102/265 (38%), Positives = 147/265 (55%), Gaps = 7/265 (2%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + S EF+PP+ + + L + L + P FVSVTYGA ++RT + ++ Sbjct: 15 RPVRSLEFYPPKDAAGVEALRATAHALRRMLPDFVSVTYGAGGSTQERTAQVSSILRKDC 74 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE------MYASDL 135 G PHLTC+ + EL +A + ++G R+I+ALRGD P GS + YA+DL Sbjct: 75 GFTVMPHLTCVGHSQLELAALADGFHDHGFRNIMALRGDPPKGSAQFTPQPDGLRYAADL 134 Query: 136 VTLLK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 VTLLK DF + VA YPE HPEA S DL NLKRKVDAGA+ TQ FFD Y RF Sbjct: 135 VTLLKSRHTDFCLGVAGYPEKHPEAASLDVDLTNLKRKVDAGADFITTQLFFDNTVYYRF 194 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGA 254 ++C + GI V I+PGI+PV + Q ++F M +P + + ++ + + +G Sbjct: 195 VEKCRAVGITVPIVPGIMPVLSLHQIQRFTAMCGATLPKQLITRLEVAAENTDVVETIGI 254 Query: 255 NIAMDMVKILSREGVKDFHFYTLNR 279 + A+ ++ L G +H Y LNR Sbjct: 255 DWALTQIRGLLANGAPGYHLYVLNR 279 >UniRef50_P42898 Methylenetetrahydrofolate reductase n=58 Tax=Metazoa RepID=MTHR_HUMAN Length = 656 Score = 331 bits (848), Expect = 3e-89, Method: Composition-based stats. Identities = 96/299 (32%), Positives = 152/299 (50%), Gaps = 13/299 (4%) Query: 5 HASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY---G 61 H R+ + + L G S EFFPPRT+E L + DR+++ P ++ VT+ G Sbjct: 42 HERLREKMRRRLE--SGDKWFSLEFFPPRTAEGAVNLISRFDRMAAGGPLYIDVTWHPAG 99 Query: 62 ANSGERD-RTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD 120 +++ + I + GLE H+TC +E+ G+++I+ALRGD Sbjct: 100 DPGSDKETSSMMIASTAVNYCGLETILHMTCCRQRLEEITGHLHKAKQLGLKNIMALRGD 159 Query: 121 LPPGSGKPE----MYASDLVTLLK-EVAD-FDISVAAYPEVHPEAKSAQADLLNLKRKVD 174 + E YA DLV ++ E D FDI VA YP+ HPEA S +ADL +LK KV Sbjct: 160 PIGDQWEEEEGGFNYAVDLVKHIRSEFGDYFDICVAGYPKGHPEAGSFEADLKHLKEKVS 219 Query: 175 AGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAW 234 AGA+ ITQ FF+ +++ RF C GI I+PGI P+ + ++ ++ + +P Sbjct: 220 AGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLEVPQE 279 Query: 235 MAQMFDGLDDDAETRKLVGANIAMDMVKILSREG-VKDFHFYTLNRAEMSYAICHTLGV 292 + + + + D+ + G +A+ + + L G V HFYTLNR + + LG+ Sbjct: 280 IKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLHFYTLNREMATTEVLKRLGM 338 >UniRef50_D0RN29 Methylenetetrahydrofolate reductase n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RN29_9RICK Length = 298 Score = 329 bits (845), Expect = 6e-89, Method: Composition-based stats. Identities = 129/278 (46%), Positives = 193/278 (69%), Gaps = 6/278 (2%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 ++ ++ SFEFFP + +E E W S+ +L S P+F SVT+GA GER +T S +K IK Sbjct: 1 MKEELKFSFEFFPSKNAEDEVAAWKSLKKLESFDPQFYSVTFGAGGGERIKTDSFVKKIK 60 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG----KPEMY--A 132 + + A HLTC+D + DE+ IA +++ GI+ IVALRGD+ P+ Y A Sbjct: 61 KESNVPVAGHLTCVDMSKDEINDIAVNWFEKGIKRIVALRGDVRKPGEQYKPHPDGYKNA 120 Query: 133 SDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYL 192 +D+ LK++A+FDISVA YPE+HP++K+ + DL NLKRKVDAGA+R ITQFFFD +L Sbjct: 121 ADMTAGLKKLANFDISVAGYPEIHPDSKNKELDLDNLKRKVDAGADRIITQFFFDENIFL 180 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV 252 +FRD GI ++++PGI+P+ N+K+ K F++ +PAW+ + F+G +D+ + +K++ Sbjct: 181 KFRDDIAKQGIKIQLLPGIMPIQNYKRVKNFSNKCGTSVPAWIEKEFEGSEDNPDVQKMI 240 Query: 253 GANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 G++IA D+VK L +EGV +FHFYTLN+ E+SYA+C L Sbjct: 241 GSSIATDLVKKLQKEGVNEFHFYTLNKYELSYAVCSRL 278 >UniRef50_B1L1W9 Methylenetetrahydrofolate reductase n=30 Tax=Bacteria RepID=B1L1W9_CLOBM Length = 295 Score = 329 bits (843), Expect = 9e-89, Method: Composition-based stats. Identities = 94/270 (34%), Positives = 147/270 (54%), Gaps = 3/270 (1%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERD-RTHSIIKGIKDR 80 ++ SFE FP + + T++ +++ L L P F+SVTYGA +D +T + +K++ Sbjct: 11 KLVFSFEIFPSKVTSSITTIYETLEELKDLTPDFISVTYGAGGSLKDNKTCELSSLVKNK 70 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG--KPEMYASDLVTL 138 G+EA HLTCI++T D++ I ++ N I +I+ALRGD+P YA +L+ Sbjct: 71 YGIEALAHLTCINSTKDDIDLIIKELKENNIENILALRGDIPKDKDIIGEYNYAFELIEK 130 Query: 139 LKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRC 198 +K +F IS A YPE H E KS D+ LKRKVDAGA I+Q FFD + F ++ Sbjct: 131 IKASNNFGISGACYPEGHIECKSLDQDIRELKRKVDAGAEHLISQLFFDNNIFYEFLNKT 190 Query: 199 VSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAM 258 I+V I GI+PV N KQ ++ ++ +P ++ D + D + + G A+ Sbjct: 191 QEKSINVPIQAGIMPVVNKKQIERIVKISGATLPKKFMKILDKYEYDKKAMEDAGIAYAV 250 Query: 259 DMVKILSREGVKDFHFYTLNRAEMSYAICH 288 + + L GVK H YT+N ++ I Sbjct: 251 EQIVDLVSSGVKGIHLYTMNNPYIARKITE 280 >UniRef50_C5FI42 Methylenetetrahydrofolate reductase n=1 Tax=Microsporum canis CBS 113480 RepID=C5FI42_NANOT Length = 715 Score = 329 bits (843), Expect = 1e-88, Method: Composition-based stats. Identities = 88/295 (29%), Positives = 140/295 (47%), Gaps = 25/295 (8%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRL-SSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 S EFFPP+T L ++R+ +L+P FV+VT+GA R+ + + + + GL Sbjct: 18 FSLEFFPPKTQMGSSNLQARLERMSQALRPLFVTVTWGAGGSTAARSLELAEICQRQLGL 77 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP----------GSGKPEMYAS 133 HLTC + + + GIR+I+ALRGD P S K +A Sbjct: 78 TTCLHLTCTNMNRTLIDEALEETKALGIRNILALRGDPPRSEEYNIDGEDDSNKDFSHAV 137 Query: 134 DLVTLLKEVAD--FDISVAAYPEV-----HPEAKSAQADLLNLKRKVDAGANRAITQFFF 186 DLV +++ F I VA YPE HPE + DL L K AGA+ +TQ + Sbjct: 138 DLVRYIRKKYGDYFCIGVAGYPEGHADESHPEVQDPLKDLPYLIEKTQAGADFIMTQLTY 197 Query: 187 DVESYLRFRDRCVSA----GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGL 242 D+E+Y ++ D + + IIPG++P+ ++ + +++ +IP + + Sbjct: 198 DIEAYRKYEDLLRNHESGTFKTIPIIPGLMPIQSYHTLTRVTKLSHAKIPPEILAKVEAC 257 Query: 243 DDDAETRKLVGANIAMDM---VKILSREGVKDFHFYTLNRAEMSYAICHTLGVRP 294 D E K VG +I ++ +K +S G + FHFYTLN + I + P Sbjct: 258 KADDEVVKRVGVDIVSELVEGIKKISTPGHRGFHFYTLNLEKSVSFILERCNLIP 312 >UniRef50_Q0AZY6 Methylenetetrahydrofolate reductase n=5 Tax=Clostridiales RepID=Q0AZY6_SYNWW Length = 295 Score = 328 bits (841), Expect = 2e-88, Method: Composition-based stats. Identities = 93/285 (32%), Positives = 149/285 (52%), Gaps = 9/285 (3%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 Q +S E FPPR + +++++++ L L P ++SVTYGA R+RT I +K Sbjct: 9 QKAPLLSLEIFPPRMAYPLESVFDTVQELKRLNPAYISVTYGAGGSNRERTVEIAARVKK 68 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM------YAS 133 G+EA HLTCI ++++ I GI +I+ALRGD+P + + YA Sbjct: 69 EYGIEAQAHLTCIGHRQEDIKNILARLNREGICNIMALRGDIPEDEPEFDFRRQEYHYAF 128 Query: 134 DLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESY 191 +L+ ++ F I+ AA+PE HPE + D+ +LK KVD G + ITQ FFD + Sbjct: 129 ELIRDIRAAYGDSFGIAAAAHPEGHPECPRLKDDIFHLKNKVDNGVDFLITQLFFDNRIF 188 Query: 192 LRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKL 251 F +RC + GI+ +IPGI+PV N Q K+ + +PA + ++ D + + + Sbjct: 189 FDFWERCQAMGINCPVIPGIMPVLNAGQIKRMIYLCGASMPAGLLKLVDKYEKEPVDMEK 248 Query: 252 VGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV-RPG 295 G + A +K L V H Y++N+ I + +G+ PG Sbjct: 249 AGIDYASQQIKELLENAVAGVHLYSMNKPRQISEIVYNIGLASPG 293 >UniRef50_A6TTI5 Methylenetetrahydrofolate reductase n=3 Tax=Clostridiales RepID=A6TTI5_ALKMQ Length = 294 Score = 327 bits (840), Expect = 2e-88, Method: Composition-based stats. Identities = 85/272 (31%), Positives = 139/272 (51%), Gaps = 4/272 (1%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + +SFE FPP+ +++ ++D L+ L P F+SVTYGA ++T I IK++ Sbjct: 11 RPVISFEIFPPKKELPISSIYGALDGLADLNPDFISVTYGAGGTGSNKTIEIASIIKNKY 70 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG----SGKPEMYASDLVT 137 +EA HLTCI + + ++ + N + +++ALRGD+P Y DL+ Sbjct: 71 EIEALAHLTCITSNKEVIQQNIKALQENNLENVLALRGDVPSDFIRREENQYQYGVDLIK 130 Query: 138 LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDR 197 LK DFDI A YPE H E + DL LK K AGAN ++Q FFD E + F ++ Sbjct: 131 ELKGYGDFDIGAAVYPEGHIECDDVEKDLQYLKEKEAAGANFLVSQLFFDNEIFYGFLEK 190 Query: 198 CVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIA 257 + I+ +++ G++P+ + KQ +K M +PA + ++ + E + G A Sbjct: 191 LKAYKIESKVLAGVMPILSKKQVEKMIFMCGASLPAKVIRLVSKYEHQPELLRQAGIEYA 250 Query: 258 MDMVKILSREGVKDFHFYTLNRAEMSYAICHT 289 + V L V H YT+N+ +++ I Sbjct: 251 AEQVADLIANEVDGIHIYTMNQPDIAKGILKR 282 >UniRef50_A2QUJ5 Methylenetetrahydrofolate reductase n=16 Tax=Leotiomyceta RepID=A2QUJ5_ASPNC Length = 699 Score = 327 bits (839), Expect = 3e-88, Method: Composition-based stats. Identities = 86/295 (29%), Positives = 144/295 (48%), Gaps = 25/295 (8%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLS-SLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 S EFFPP+T L ++R++ +L+P FV+VT+GA R+ + + + + L Sbjct: 18 FSLEFFPPKTKMGFANLQARLERMAQALRPLFVTVTWGAGGSTAARSLELAEICQRQLQL 77 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP----------GSGKPEMYAS 133 HLTC + + + + GIR+I+ALRGD P S K +A Sbjct: 78 TTCLHLTCTNMSRALVDEALEEAKVLGIRNILALRGDPPRSEEYNMHGEDDSNKDFTFAV 137 Query: 134 DLVTLLKEVAD--FDISVAAYPEVHP-----EAKSAQADLLNLKRKVDAGANRAITQFFF 186 DLV +++ F I VAAYPE HP + + DL L K AGA+ +TQ + Sbjct: 138 DLVRYIRKQYGDYFCIGVAAYPEGHPADNFQDGQDPARDLPFLIEKTQAGADFIMTQLTY 197 Query: 187 DVESYLRFRDRCVSA----GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGL 242 D+E+Y +F + + I+PG++P+ ++K + +++V+IP + + + Sbjct: 198 DLEAYTKFETMLRNHESGVFKTIPIVPGLMPIHSYKILTRVTKLSHVKIPPHVLSKLEEV 257 Query: 243 DDDAETRKLVGANIAMDM---VKILSREGVKDFHFYTLNRAEMSYAICHTLGVRP 294 D + K +G +I D+ ++ L G++ FHFYTLN + I + P Sbjct: 258 KHDDDAVKRIGVDIISDLVHGIRDLVSPGLRGFHFYTLNLEKTVSFILERCELIP 312 >UniRef50_Q2HBA5 Methylenetetrahydrofolate reductase n=2 Tax=Leotiomyceta RepID=Q2HBA5_CHAGB Length = 643 Score = 327 bits (838), Expect = 3e-88, Method: Composition-based stats. Identities = 94/303 (31%), Positives = 150/303 (49%), Gaps = 29/303 (9%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLS-SLKPKFVSVTYGANSGERDRTHSIIKGI 77 GQ S EFFPP+T+ L + +DR++ +L+P FV+VT+GA ++ + + Sbjct: 31 PAGQDYFSLEFFPPKTAMGFSNLRSRLDRMARALRPLFVNVTWGAGGSTATKSLELAEIC 90 Query: 78 KDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM------- 130 + GL HLTC + + + D GIR+I+ALRGD P + + Sbjct: 91 QRELGLTTCLHLTCTNMSRRLIDKALDDAKALGIRNILALRGDPPRRAEYRDANEPEPEE 150 Query: 131 -----YASDLVTLLKEVAD--FDISVAAYPEV-----HPEAKSAQADLLNLKRKVDAGAN 178 +A DLV +++ F I VAAYPE HP +S + DL L K AGA+ Sbjct: 151 EEEFSWAVDLVRYIRKTHGDYFCIGVAAYPEGHADESHPLGQSLEHDLPYLVEKTQAGAD 210 Query: 179 RAITQFFFDVESYLRF----RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAW 234 +TQ FFDVE+Y F R+ A ++ I+PG++P+ +++ K+ +++ IP Sbjct: 211 FIMTQLFFDVEAYNHFEKTLREHPSGAFKNITILPGLMPIQSYQMIKRTTKLSHANIPDS 270 Query: 235 MAQMFDGLDDDAETRKLVGANIAMDMVKILSR-----EGVKDFHFYTLNRAEMSYAICHT 289 + D + D E K VG +I ++V+ + + + FHFYTLN + I Sbjct: 271 LMARLDAVKGDDEKVKEVGVDILSEIVEQIKEVKSRTDEPRGFHFYTLNLEKAVSFIVER 330 Query: 290 LGV 292 G+ Sbjct: 331 TGL 333 >UniRef50_C8V780 Methylenetetrahydrofolate reductase n=17 Tax=Leotiomyceta RepID=C8V780_EMENI Length = 684 Score = 327 bits (838), Expect = 4e-88, Method: Composition-based stats. Identities = 88/301 (29%), Positives = 146/301 (48%), Gaps = 25/301 (8%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLS-SLKPKFVSVTYGANSGERDRTHSIIKGI 77 G S EFFPP+T L ++R++ +L+P FV+VT+GA R+ + + Sbjct: 12 PPGANYFSLEFFPPKTQMGFANLQARLERMAQALRPLFVTVTWGAGGSTAARSLELAEIC 71 Query: 78 KDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP----------GSGK 127 + + L HLTC + + + + GIR+I+ALRGD P S K Sbjct: 72 QRQLQLTTCLHLTCTNMSRALVDQALEEAKVLGIRNILALRGDPPRSEEYNMHGEDDSNK 131 Query: 128 PEMYASDLVTLLKEVAD--FDISVAAYPEVHP-----EAKSAQADLLNLKRKVDAGANRA 180 +A DLV +++ F + VAAYPE HP + + + DL L K AGA+ Sbjct: 132 DFTFAVDLVRYIRKKYGDYFCVGVAAYPEGHPADSFQDIQDPKVDLPWLVEKTQAGADFI 191 Query: 181 ITQFFFDVESYLRFRDRCVSA----GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMA 236 +TQ +D+++Y F + + + IIPG++P+ ++K + +++V+IP + Sbjct: 192 MTQLTYDIDAYTEFENLLRNHESGTFKTIPIIPGLMPIHSYKILTRVTKLSHVKIPPPIL 251 Query: 237 QMFDGLDDDAETRKLVGANIAMDMV---KILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 D + D + K +G +I ++V K L G++ FHFYTLN + I + Sbjct: 252 AKLDEVKHDDDAVKRLGVDILAELVDGMKKLPTPGLRGFHFYTLNLEKTVSFILERCKLI 311 Query: 294 P 294 P Sbjct: 312 P 312 >UniRef50_Q5KN82 Methylenetetrahydrofolate reductase n=1 Tax=Filobasidiella neoformans RepID=Q5KN82_CRYNE Length = 633 Score = 326 bits (836), Expect = 7e-88, Method: Composition-based stats. Identities = 91/282 (32%), Positives = 137/282 (48%), Gaps = 16/282 (5%) Query: 27 FEFFPPRTSEMEQTLWNSIDRLSS---LKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 +EFFPP T L + I RL+S P VSVT+GA +++ + + + D G+ Sbjct: 18 YEFFPPLTDPGFVNLLDRIRRLTSSPFQAPLAVSVTWGAGGSTAEKSLELAQQVVD-MGV 76 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG---------KPEMYASD 134 E HLTC + D++ R + GI +I+ALRGD P +A D Sbjct: 77 EVILHLTCTNMPKDKVDFALRRCKDLGISNILALRGDPPREEEYAINPTSTPDFFKHADD 136 Query: 135 LVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYL 192 LV +++ F I VA YP HP+++S + D K K DAGA+ +TQ F+DV+ +L Sbjct: 137 LVRYIRQTHGDYFCIGVAGYPNPHPDSESEEEDFKWFKAKCDAGADFIVTQLFYDVDVFL 196 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV 252 + C + GI+ IIPGI+P+ N+ ++ ++T +P + + D T K Sbjct: 197 EWVKTCRARGINQPIIPGIMPIQNYASFRRLVNLTKCPVPDSITSDLQPISSDDATVKRY 256 Query: 253 GANIAMDMVKILSREG-VKDFHFYTLNRAEMSYAICHTLGVR 293 GA +A MV + G V H TLN + I LG Sbjct: 257 GAELATKMVSQIIESGLVPGVHLCTLNLEKSVRMILDNLGWS 298 >UniRef50_D1ZNB9 Methylenetetrahydrofolate reductase n=1 Tax=Sordaria macrospora RepID=D1ZNB9_SORMA Length = 758 Score = 325 bits (835), Expect = 8e-88, Method: Composition-based stats. Identities = 94/302 (31%), Positives = 148/302 (49%), Gaps = 29/302 (9%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSS-LKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 Q S EFFPP+T+ L + ++R++ L+P FV+VT+GA ++ + + + Sbjct: 91 QHYFSLEFFPPKTAMGFANLRDRLERMARGLRPLFVNVTWGAGGSTAQKSLELAEICQRE 150 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP------------PGSGKP 128 GL HLTC + + L D GIR+I+ALRGD P P + Sbjct: 151 LGLTTCLHLTCTNMSRRLLDKTLEDAKVLGIRNILALRGDPPRAAEYHDENDPEPTDDEE 210 Query: 129 EMYASDLVTLLKEVAD--FDISVAAYPEV-----HPEAKSAQADLLNLKRKVDAGANRAI 181 +A+DLV +K+ F I VAAYPE HP +S + DL L KV AGA+ + Sbjct: 211 FSWAADLVRYIKKNHGDYFCIGVAAYPEGHADQSHPREQSLEHDLPYLVEKVQAGADFIM 270 Query: 182 TQFFFDVESYLRFRDRCV----SAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQ 237 TQ FFD+++Y F + A DV IIPG++P+ +++ K+ +++ +IP + Sbjct: 271 TQLFFDIDAYEHFENTLRGHPSGAFKDVLIIPGLMPIQSYQMIKRTTKLSHAKIPPALMA 330 Query: 238 MFDGLDDDAETRKLVGANIAMDMVKILSR-----EGVKDFHFYTLNRAEMSYAICHTLGV 292 D + D E K+ G I ++++ + + FHFYTLN + I + Sbjct: 331 RLDAVKGDDEKVKMEGVAIVSEIIERIKEIKSRTHTPRGFHFYTLNLEKAVAFIAEGTNL 390 Query: 293 RP 294 P Sbjct: 391 IP 392 >UniRef50_C5RR04 Methylenetetrahydrofolate reductase n=1 Tax=Clostridium cellulovorans 743B RepID=C5RR04_CLOCL Length = 285 Score = 325 bits (835), Expect = 9e-88, Method: Composition-based stats. Identities = 89/275 (32%), Positives = 144/275 (52%), Gaps = 2/275 (0%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 + + S E FPP+ ++ + N++D L+ L FVSVTYGA RD T + K IK Sbjct: 9 NRQSFSVELFPPKKTDSFDNIINTLDNLNGLDIDFVSVTYGAGGSSRDNTVKLSKKIKSE 68 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM-YASDLVTLL 139 LE HLTCI++ DE+ ++ + N + +I+ALRGD+P + YASDL+ + Sbjct: 69 YNLEVITHLTCINSKKDEIASLLDEMKENNLENILALRGDIPSEVIYDDYKYASDLIPEI 128 Query: 140 KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199 K + DF + A YPE HPEA S D+ LK+K G + I+Q F D + F++R Sbjct: 129 KSLGDFCVGAACYPEKHPEAPSNVYDIKKLKQKTALGCDFLISQLFLDNTMFFNFQERLE 188 Query: 200 SAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMD 259 A ++ +++ GI+PV N Q ++ ++ +P ++ + + + K G A+D Sbjct: 189 LADVNTKVLAGIMPVINKAQFERIIQLSGCNVPPKFKKILEKYEHNPSALKDAGIAYAID 248 Query: 260 MVKILSREGVKDFHFYTLNRAEMSYAICHTL-GVR 293 + L V H Y +N+ E + I + G+R Sbjct: 249 QIIDLMCHDVDGIHLYIMNKPENAKRILDNITGLR 283 >UniRef50_Q28TL9 Methylenetetrahydrofolate reductase n=3 Tax=Rhodobacteraceae RepID=Q28TL9_JANSC Length = 288 Score = 325 bits (834), Expect = 1e-87, Method: Composition-based stats. Identities = 123/280 (43%), Positives = 160/280 (57%), Gaps = 7/280 (2%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 NVSFEFFPP++ E LW ++ L+ L P FVSVTYGA R TH + I G Sbjct: 4 PNVSFEFFPPKSLEGSFKLWETLGVLAPLDPTFVSVTYGAGGTTRKLTHEAVTAINANFG 63 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY------ASDLV 136 + A HLTC+DAT E IA Y GI IVALRGD P G+ + + + DLV Sbjct: 64 VPVAAHLTCVDATRAETLEIADQYAQAGITQIVALRGDPPKGTATFQAHPDGFGSSEDLV 123 Query: 137 TLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRD 196 L + FDI V AYP+ HPEA S QA + LK K+DAGA AITQFFF+ +++ RFRD Sbjct: 124 AALAKTGKFDIRVGAYPDPHPEAASMQACVDYLKAKIDAGATSAITQFFFEADTFFRFRD 183 Query: 197 RCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANI 256 C +AGI I+PGILP+ ++ +A++FA IP W+ + D L+ I Sbjct: 184 ACAAAGITAPILPGILPIEDWSRARRFATACGAVIPTWLDDAYTSAIRDGRE-DLLSTAI 242 Query: 257 AMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 ++ L GV D HFYTLNR E++ +C LGV P + Sbjct: 243 CTELCTDLIEGGVDDLHFYTLNRPELTRDVCAALGVAPNV 282 >UniRef50_UPI0001C36AF7 5,10-methylenetetrahydrofolate reductase n=1 Tax=Clostridium hathewayi DSM 13479 RepID=UPI0001C36AF7 Length = 293 Score = 325 bits (834), Expect = 1e-87, Method: Composition-based stats. Identities = 90/276 (32%), Positives = 142/276 (51%), Gaps = 3/276 (1%) Query: 18 EVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG-ERDRTHSIIKG 76 E + +SFE FPP+ + + ++ L L P ++SVT+GA G R+RT + K Sbjct: 14 ETPSKKTLSFEIFPPKKDSELKNIDKTLSVLCELNPDYISVTFGAGGGANRNRTIELAKR 73 Query: 77 IKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM--YASD 134 IK +E HLTC+ E+ AR N G+++++ALRGD P + E +ASD Sbjct: 74 IKQEYHVEPVVHLTCLHYDKAEIDEFARVLTNAGLQNVLALRGDKNPNMREKESFLHASD 133 Query: 135 LVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 L+ +K+ DF A YPE HPE++ ++ +LK KV+AGA ++Q FD ++ RF Sbjct: 134 LIAYMKDKWDFCFLGACYPECHPESEDKVCEIKHLKAKVNAGAEVLLSQLCFDNHAFFRF 193 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGA 254 ++ C A I +IPGI+PV N Q K+ M P ++ + + E G Sbjct: 194 QEACRIADIQAPVIPGIMPVINAAQIKRMITMCGATFPVRFQKIIQAYESNKEALFDAGM 253 Query: 255 NIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + A+ + L V+ H YT+N ++ IC + Sbjct: 254 SYALSQIIDLLVSDVEGIHLYTMNNPLVARRICEGI 289 >UniRef50_C5DIA7 Methylenetetrahydrofolate reductase n=2 Tax=Saccharomycetaceae RepID=C5DIA7_LACTC Length = 660 Score = 325 bits (833), Expect = 1e-87, Method: Composition-based stats. Identities = 90/291 (30%), Positives = 143/291 (49%), Gaps = 20/291 (6%) Query: 17 AEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKG 76 E +S EFFPP+T +Q L + R+++L P F+++T+GA +T + Sbjct: 27 YESTDGPFISLEFFPPKTKLGKQNLTARMTRMTALNPLFITITWGAGGTTAKKTLELATV 86 Query: 77 IKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP-------PGSGKPE 129 + + HLTC + + + + IR+I+ALRGD P P Sbjct: 87 AQRELNVPVCMHLTCTNTNKEIIDEALKLAHEADIRNILALRGDPPVGEEWETPSESSEF 146 Query: 130 MYASDLVTLLKEVA--DFDISVAAYPEVHPE------AKSAQADLLNLKRKVDAGANRAI 181 +A DLV +KE DF + VAAYPE H E A+ + DL LK KVDAGA+ I Sbjct: 147 QHAVDLVRYIKEKYNDDFCVGVAAYPEGHCEGEADGVAQDPRRDLGFLKEKVDAGADFVI 206 Query: 182 TQFFFDVESYLRFRDRCVSA-GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMF- 239 TQ F+DVE +L F + D+ + PG++P++++ + A +++ IP + Sbjct: 207 TQLFYDVEKFLSFEQMFRNEVSADIPLFPGLMPINSYLLFNRAAKLSHASIPQAIRDRLP 266 Query: 240 DGLDDDAETRKLVGANIAMDMVKILSR--EG-VKDFHFYTLNRAEMSYAIC 287 D + +G +I ++MV+ + + EG +K HFYTLN + I Sbjct: 267 QEYHSDDNKVRAIGVDILVEMVEEIYKRTEGRIKGIHFYTLNLEKAIAQIV 317 >UniRef50_A8MFK9 Methylenetetrahydrofolate reductase n=7 Tax=Clostridiales RepID=A8MFK9_ALKOO Length = 298 Score = 324 bits (832), Expect = 2e-87, Method: Composition-based stats. Identities = 91/274 (33%), Positives = 156/274 (56%), Gaps = 5/274 (1%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERD-RTHSIIKGIKDR 80 + SFE FPP+ + +++++++ L LKP ++SVTYGA D RT I IK++ Sbjct: 11 NLVFSFEVFPPKVTSPIGSIYDTLEGLQDLKPDYISVTYGAGGNGNDNRTGEIAAIIKNK 70 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG-SGKPEM-YASDLVTL 138 G+EA HLTCI +T ++ + + ++ + G+ +++ALRGD+P G GK E+ + DL+ L Sbjct: 71 YGIEALAHLTCIGSTLEQTKGVLQELRDKGVHNVLALRGDIPEGFEGKGELKNSQDLIRL 130 Query: 139 LKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRD 196 ++E F I+ A YPE H E K+ D+ LK K +AGA+ AITQ FFD + F + Sbjct: 131 IREDQGNRFGIAAACYPEGHVEGKNVDQDIEILKLKEEAGADHAITQLFFDNNYFYEFLN 190 Query: 197 RCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANI 256 + GI + I GI+PV+N KQ ++ ++ +P ++ + + + E + G Sbjct: 191 KVEEKGIQLPIQAGIMPVTNKKQIERIVALSGANLPVKFKKIMEKYEHNKEALRDAGIAY 250 Query: 257 AMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 A+D + L G + H YT+N ++ ++ ++ Sbjct: 251 ALDQIVDLISTGARGIHLYTMNNPYIARSVTESI 284 >UniRef50_C4XPB4 Methylenetetrahydrofolate reductase n=11 Tax=Deltaproteobacteria RepID=C4XPB4_DESMR Length = 330 Score = 324 bits (830), Expect = 3e-87, Method: Composition-based stats. Identities = 98/278 (35%), Positives = 140/278 (50%), Gaps = 9/278 (3%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + VS EFFPP+ E + +++L ++P FVSVTYGA T I+ +K Sbjct: 51 RPFVSLEFFPPKEREAWDGFFGVVEKLIPVRPLFVSVTYGAGGSTHAHTLEIVSRLKTAY 110 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG------SGKPEMYASDL 135 GLE HLTC+ A+ D++R G+ +++ALRGD P G + +ASDL Sbjct: 111 GLEPMAHLTCVGASKDKIRGFLGALAQAGVDNVLALRGDPPKGQETFVPDSEDFQHASDL 170 Query: 136 VTLLK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 V ++ E + + VA YPE HPEA S Q DL +L+ K+ G + A+TQ FFD + Y F Sbjct: 171 VAFIRAEYPNLCLGVAGYPECHPEAVSPQEDLEHLRHKLALGGSFAVTQLFFDNDRYFDF 230 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFD--GLDDDAETRKLV 252 R +AGID ++PG+LPV + K+FA + +P + V Sbjct: 231 VARARAAGIDAPMVPGVLPVLSLASIKRFAALCGASLPPAYMAELEAADAAGGNAAVAEV 290 Query: 253 GANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 G A + L R G H YTLN+AE +I L Sbjct: 291 GIAYARKQAQDLLRRGAPGVHLYTLNKAEAVLSIVSGL 328 >UniRef50_C7N1R9 Methylenetetrahydrofolate reductase n=2 Tax=Coriobacteriaceae RepID=C7N1R9_SLAHD Length = 286 Score = 323 bits (829), Expect = 4e-87, Method: Composition-based stats. Identities = 101/273 (36%), Positives = 142/273 (52%), Gaps = 3/273 (1%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANS-GERDRTHSIIKGIK 78 G+I VSFE FPP+ + + L+ L P FVSVTY A G +RT + K + Sbjct: 9 PGKIPVSFETFPPKGEMPVEEARGLMAGLAPLNPAFVSVTYSAGGAGNSERTVDVAKMGQ 68 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP-EMYASDLVT 137 D GL HLTC+ AT + + GI +++ALRGD PG YA DL+ Sbjct: 69 DEFGLTCMAHLTCMGATKESVAREFERMREAGIENVLALRGDKVPGRDADVFHYAKDLIP 128 Query: 138 LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDR 197 L +E A F + AAYPE H + A + +LK K DAGA +TQ FF+ + LRF D Sbjct: 129 LARE-AGFCVGAAAYPEGHVDCLDFDASIRHLKEKQDAGAEFFVTQLFFENDVALRFLDA 187 Query: 198 CVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIA 257 SAGI V I GI+P + Q + M +P+ + ++ + +DD E+ + G A Sbjct: 188 ARSAGITVPITFGIMPFMSKAQLTRMIFMCGASLPSPIIKLLNHYEDDEESLRQAGIEYA 247 Query: 258 MDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + L REGV H YT+NRA+++ A+ L Sbjct: 248 CNQFVELGREGVDGLHVYTMNRADIASAVMEAL 280 >UniRef50_Q17693 Probable methylenetetrahydrofolate reductase n=5 Tax=Chromadorea RepID=MTHR_CAEEL Length = 663 Score = 323 bits (829), Expect = 4e-87, Method: Composition-based stats. Identities = 91/290 (31%), Positives = 141/290 (48%), Gaps = 12/290 (4%) Query: 14 QSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERD----- 68 + L + + Q S EFFPPR ++RLS FV +T+ S + Sbjct: 63 ERLIDEKQQF-FSLEFFPPRFVNGVPNFLERVERLSEGGSVFVDMTWHMGSDPANVDKVT 121 Query: 69 RTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP 128 + SI + D G++ H+TC+ + G+R I+ALRGDLPPG+ Sbjct: 122 SSSSIAASMLDYCGVDTMLHMTCVQYNKADTLKHLEQAKAMGLRSILALRGDLPPGTELE 181 Query: 129 EMY---ASDLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQ 183 + + A D++ ++E F I A YP HP+A S +ADL+ LK K DAGAN ITQ Sbjct: 182 DTHQFRALDMIRWIREEYGNYFSIGCAGYPLGHPQAPSYKADLMYLKAKCDAGANFVITQ 241 Query: 184 FFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLD 243 FF+ E++ +F C GI IIPGI+P+ ++ K+ A ++ + IP + + + Sbjct: 242 LFFEAETFEKFVRDCREIGITQPIIPGIMPIMGYESIKRIAKLSQLEIPQHILDDLEPIK 301 Query: 244 DDAETRKLVGANIAMDMVKILSREG-VKDFHFYTLNRAEMSYAICHTLGV 292 D + + G ++M + L G H YT+NR I +LG+ Sbjct: 302 HDDDAVQKYGTERCIEMCRRLLDNGTAPSIHLYTMNREGSIREILKSLGL 351 >UniRef50_C4R2L4 Methylenetetrahydrofolate reductase n=1 Tax=Pichia pastoris GS115 RepID=C4R2L4_PICPG Length = 596 Score = 323 bits (829), Expect = 4e-87, Method: Composition-based stats. Identities = 90/296 (30%), Positives = 152/296 (51%), Gaps = 17/296 (5%) Query: 14 QSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSI 73 + E++G+ SFEFFPP+T + L + R+S L P FV+VT+GA +T + Sbjct: 6 DKIKELKGEPFYSFEFFPPKTDNGLRNLLARLGRMSMLNPLFVTVTWGAGGTTSSKTLDL 65 Query: 74 IKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS-----GKP 128 + L HLTC + + + + ++NGI++I+ALRGD P + + Sbjct: 66 AITCQKDLDLTTCIHLTCTNTSKKLIDNALKAAYDNGIKNILALRGDPPREAQEVAVDQD 125 Query: 129 EMYASDLVTLLK-EVAD-FDISVAAYPEVHPEA-----KSAQADLLNLKRKVDAGANRAI 181 YA DLV ++ + D F I VAAYPE H E +S D+ L K++AGA+ + Sbjct: 126 FKYAIDLVRYIRGQYGDYFCIGVAAYPEGHVEGNDDSEQSIDHDMPYLLEKINAGADFVV 185 Query: 182 TQFFFDVESYLRFRDRCVSA-GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFD 240 TQ F+D + + F + G DV +IPG++P++ ++ ++ ++++ IP + Q+F Sbjct: 186 TQLFYDADKFCTFYNTLKQRLGRDVVVIPGLMPINTYQLFQRATNLSHASIPPAVGQLFP 245 Query: 241 G-LDDDAETRKLVGANIAMDMVKILSRE---GVKDFHFYTLNRAEMSYAICHTLGV 292 + D + K +G + +D+V + E V +HFYTLN + I + Sbjct: 246 PDVRHDDDKVKDIGVKLMIDIVDQIYNETHGEVNGYHFYTLNLEKSVAQIVDKSSL 301 >UniRef50_C4Y9Q4 Methylenetetrahydrofolate reductase n=1 Tax=Clavispora lusitaniae ATCC 42720 RepID=C4Y9Q4_CLAL4 Length = 601 Score = 323 bits (828), Expect = 5e-87, Method: Composition-based stats. Identities = 86/282 (30%), Positives = 136/282 (48%), Gaps = 15/282 (5%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + SFEFFPP+T + L + R+ L P FVSVT+GA +++ + + Sbjct: 14 EKFCSFEFFPPKTDAGFRNLLARLHRMRDLNPLFVSVTWGAGGSTSEKSLELAVTCQQLL 73 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP-----EMYASDLV 136 G+ HLTC + + GIR+I+ALRGD P A DLV Sbjct: 74 GISTVLHLTCTNTNKAIIDDALSRAKAAGIRNILALRGDPPRTREYWTPECSFRTAVDLV 133 Query: 137 TLLK-EVAD-FDISVAAYPEVHPEA-----KSAQADLLNLKRKVDAGANRAITQFFFDVE 189 ++ + D F I VA YPE H + + + DL L+ KV AGA+ +TQ FFD + Sbjct: 134 RYIRAQYGDYFCIGVAGYPEGHVDGSDGAEQDPKRDLPYLEEKVAAGASFVVTQMFFDAD 193 Query: 190 SYLRFRDRCVSAGI--DVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAE 247 Y+ F ++ + DV +IPG++P++ +K + +++ +PA +A+ D + Sbjct: 194 KYVAFEKMVRASPVLKDVVLIPGLMPITTYKVFTRATKLSHASVPAAVAEQLSSAAVDDD 253 Query: 248 TRKLVGANIAMDMVKILSREG-VKDFHFYTLNRAEMSYAICH 288 K +G ++ +V +S + FHFYTLN AI Sbjct: 254 QVKKIGVDVLSQLVADVSARSAARGFHFYTLNLERAVAAIVE 295 >UniRef50_Q169G2 Methylenetetrahydrofolate reductase n=39 Tax=Rhodobacterales RepID=Q169G2_ROSDO Length = 289 Score = 323 bits (828), Expect = 6e-87, Method: Composition-based stats. Identities = 128/280 (45%), Positives = 162/280 (57%), Gaps = 7/280 (2%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 VSFE FPPR+ + LW + L+ L P+F SVTYGA RD TH + +G Sbjct: 4 PEVSFEVFPPRSIDASFKLWETAQALAPLAPRFFSVTYGAGGTTRDLTHDAAYTLHKSSG 63 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG----KPEMYA--SDLV 136 L A HLTC+ A+ E IA+ + GI IVALRGD P GS P+ +A +L+ Sbjct: 64 LPVAAHLTCVGASKSETLAIAQRFAQAGITDIVALRGDAPEGSNGFTPHPDGFANAVELI 123 Query: 137 TLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRD 196 L F + V AYPE HPEA S QA++ LK KVDAGA AITQFFF+ +++LRFRD Sbjct: 124 DALARSGQFTLRVGAYPEKHPEAASQQANIDWLKAKVDAGACEAITQFFFEADTFLRFRD 183 Query: 197 RCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANI 256 CV AGI V I PGILP++N+ A+KFA IPAW+ Q FD D L+ + Sbjct: 184 DCVRAGISVPITPGILPITNWTNARKFAQRCGTSIPAWLDQAFDAAIRDD-RHDLLSRAL 242 Query: 257 AMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 ++ L EGV HFYTLNR E++ ICH LGV + Sbjct: 243 CTELCSDLVGEGVDKLHFYTLNRPELTREICHALGVTQAV 282 >UniRef50_P46151 Methylenetetrahydrofolate reductase 1 n=10 Tax=Saccharomycetaceae RepID=MTHR1_YEAST Length = 657 Score = 322 bits (827), Expect = 8e-87, Method: Composition-based stats. Identities = 89/295 (30%), Positives = 146/295 (49%), Gaps = 21/295 (7%) Query: 14 QSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSI 73 + L + +S EFFPP+T + L + R+++L P F++VT+GA ++T ++ Sbjct: 4 RDLYHARASPFISLEFFPPKTELGTRNLMERMHRMTALDPLFITVTWGAGGTTAEKTLTL 63 Query: 74 IKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG------- 126 + + HLTC + + +N GIR+I+ALRGD P G Sbjct: 64 ASLAQQTLNIPVCMHLTCTNTEKAIIDDALDRCYNAGIRNILALRGDPPIGEDWLDSQSN 123 Query: 127 -KPEMYASDLVTLLKEVAD--FDISVAAYPEVHPEA------KSAQADLLNLKRKVDAGA 177 P YA DLV +K+ F + VAAYPE H E + DL+ LK KV+AGA Sbjct: 124 ESPFKYAVDLVRYIKQSYGDKFCVGVAAYPEGHCEGEAEGHEQDPLKDLVYLKEKVEAGA 183 Query: 178 NRAITQFFFDVESYLRFRDRCVSA-GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMA 236 + ITQ F+DVE +L F D+ + PG++P++++ + A +++ IP + Sbjct: 184 DFVITQLFYDVEKFLTFEMLFRERISQDLPLFPGLMPINSYLLFHRAAKLSHASIPPAIL 243 Query: 237 QMFDG-LDDDAETRKLVGANIAMDMVKILSREG---VKDFHFYTLNRAEMSYAIC 287 F + D K +G +I +++++ + + +K FHFYTLN + I Sbjct: 244 SRFPPEIQSDDNAVKSIGVDILIELIQEIYQRTSGRIKGFHFYTLNLEKAIAQIV 298 >UniRef50_C0WB69 Methylenetetrahydrofolate reductase n=1 Tax=Acidaminococcus sp. D21 RepID=C0WB69_9FIRM Length = 288 Score = 320 bits (820), Expect = 5e-86, Method: Composition-based stats. Identities = 90/273 (32%), Positives = 145/273 (53%), Gaps = 5/273 (1%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 ++ +S E FPP+ Q + + ++ ++SVTYGA ++ +I + +R+ Sbjct: 11 KVTISCELFPPKKGTELQNAMDIVHAIAIDGVDYMSVTYGAGGTAVGKSLAIASEV-ERS 69 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK----PEMYASDLVT 137 G+ A HLTCI A D + + RD GI +++ALRGD P G + +ASDLV Sbjct: 70 GVPALAHLTCIGAKKDGIARVLRDMKAGGIDNVLALRGDRPQGMDELPESDFPHASDLVR 129 Query: 138 LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDR 197 +KE DF + A YPE HPE+++ DL N+KRKVDAG + +TQ FFD E + F R Sbjct: 130 FIKETGDFCVGCATYPEGHPESRTLDEDLENMKRKVDAGCDFLVTQMFFDNEMFYNFMYR 189 Query: 198 CVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIA 257 ++ G+ V ++ G++P++N KQ ++ ++ IP+ + + + D E + G Sbjct: 190 LLAKGVRVPVVAGVMPITNAKQVERIFTLSGTPIPSKLRAVVERFGDHPEALRQAGMAYT 249 Query: 258 MDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + L G H YT+N+ E+ I TL Sbjct: 250 TGQIMDLIANGFNHIHVYTMNKPEVIGGIRRTL 282 >UniRef50_C6PS47 Methylenetetrahydrofolate reductase n=1 Tax=Clostridium carboxidivorans P7 RepID=C6PS47_9CLOT Length = 285 Score = 320 bits (820), Expect = 5e-86, Method: Composition-based stats. Identities = 84/279 (30%), Positives = 140/279 (50%), Gaps = 4/279 (1%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 ++ +++ SFE FPP++ + + L ++++ L P F+S TYGA R I K IK Sbjct: 7 MKKKMSFSFEVFPPKSDKPIEPLLDTLEHLYEFNPDFISCTYGAGGTNAGRNMEICKAIK 66 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK---PEMYASDL 135 D H TCI T ++++ + Y + G+ HI+ALRGDLP G YA++L Sbjct: 67 DSGKSIPVTHYTCIGNTKEKMKQELQRYLDMGVDHILALRGDLPKGWEGTRGDFNYANEL 126 Query: 136 VTLLK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 V +K F I+V+ PE H E+ S D+ +L+ K DAGA+ +TQ DV+ Y + Sbjct: 127 VQYIKSNFPKFTIAVSGNPEKHFESYSFDEDITHLRIKQDAGADYIMTQLCHDVDQYCWW 186 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGA 254 ++ AG+ + I G++P+ + + A IP +A++ D+ E K G Sbjct: 187 VEKIRKAGVSMPIDVGVMPILSKDPTIRMAVSNGSSIPRDLAEIIARYGDNPEDFKKAGK 246 Query: 255 NIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 + + G+ H Y+LN+ + I +G+R Sbjct: 247 EYSAKQIFKFINAGIDGLHIYSLNKWQDVTDIIKDVGIR 285 >UniRef50_C9RM26 Methylenetetrahydrofolate reductase n=23 Tax=Bacteria RepID=C9RM26_FIBSS Length = 296 Score = 319 bits (818), Expect = 8e-86, Method: Composition-based stats. Identities = 87/278 (31%), Positives = 142/278 (51%), Gaps = 7/278 (2%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 Q ++++SFE FPP+ + + + + ++ L P F+SVTYGA G T I K +K Sbjct: 9 QDKMSLSFEVFPPKKETSFENVKAATEAIAKLNPAFMSVTYGAGGGVSQYTLEIAKNLKY 68 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP------GSGKPEMYAS 133 + HLTCI +T + + D GI++++ALRGDL P +A Sbjct: 69 NFNIPMLAHLTCISSTKETIHQRIEDMKAAGIKNVMALRGDLTPELIANGRGDCDYHHAV 128 Query: 134 DLVTLLKEV-ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYL 192 +L+ LK ADF I A YPE HPE+ + D+ +LK KV+AGA+ TQ FD + Sbjct: 129 ELIRELKAADADFCIGAACYPEKHPESPNQAEDIKHLKEKVEAGADFLTTQMVFDNNLFF 188 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV 252 F + AG++ ++PGI+P++N Q ++ ++ +P + D D E K Sbjct: 189 SFLYKLRDAGVNCPVLPGIMPITNANQVERAIKLSGSFMPQHFKSLVDKFGSDPEAMKQA 248 Query: 253 GANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 G A D + L G+ + H Y++N+ +++ I + Sbjct: 249 GIIYATDQIIDLYANGITNVHVYSMNKPDVAEGILKNV 286 >UniRef50_Q30YC4 Methylenetetrahydrofolate reductase n=5 Tax=Desulfovibrio RepID=Q30YC4_DESDG Length = 316 Score = 319 bits (818), Expect = 8e-86, Method: Composition-based stats. Identities = 99/298 (33%), Positives = 145/298 (48%), Gaps = 11/298 (3%) Query: 5 HASQRDALNQSLAEVQGQ---INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYG 61 H + + ++ GQ S E+FPP+ EM + ++ RL +L P F SVTYG Sbjct: 16 HLRSNKDSDVKIKDLIGQHDGPFYSLEYFPPKNPEMWPKFFANVGRLMALNPVFCSVTYG 75 Query: 62 ANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL 121 A G +D T I + K LE PHLTC+ AT D++R + G+ +++ALRGD Sbjct: 76 AGGGTQDNTFEITRRFKQDLDLEPMPHLTCVGATKDKIRGFVSQLRDIGVDNVLALRGDA 135 Query: 122 PPGSG-----KPEMYASDLVTLLK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDA 175 P +G +ASDLV + E + + VA YP HPE+ S DL K K+DA Sbjct: 136 PADAGFSWDDGEFRHASDLVEFVNAEFPEMCVGVAGYPTAHPESASFAEDLHWTKAKIDA 195 Query: 176 GANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWM 235 G++ + Q FDV Y F + + G+ ++PGILP+ + + ++ + IP Sbjct: 196 GSDFIVCQLLFDVREYFHFVAQLRAMGVTSPVLPGILPIQSLESVRRILSLCGANIPGRF 255 Query: 236 AQMFDGLD--DDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 + D A K +G A DM++ L GV H YTLN+AE I G Sbjct: 256 YLQLEEADAKGGAAAVKELGTKFAADMIRRLVDGGVPGVHLYTLNQAETCLRIAEMAG 313 >UniRef50_A9UZU5 Methylenetetrahydrofolate reductase n=1 Tax=Monosiga brevicollis RepID=A9UZU5_MONBE Length = 332 Score = 319 bits (817), Expect = 1e-85, Method: Composition-based stats. Identities = 95/311 (30%), Positives = 139/311 (44%), Gaps = 38/311 (12%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 +G+ VSFEFFPPRT + +L + I R + +P F+ +T+GA D T + + Sbjct: 16 KGEKFVSFEFFPPRTDDGVTSLMSRIQRYNDQQPLFMDMTWGAGGSTSDLTLDLCTRMVK 75 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY------AS 133 G A HLTC + +++ + + GIR+IVALRGD P G E A Sbjct: 76 ECGANANMHLTCTNMPSEKIDIALKGARDAGIRNIVALRGDPPAGEEAWEAVEGGYSCAL 135 Query: 134 DLVTLLKEVAD--FDISVAAYPEVHPEA------------------------------KS 161 DLV +++ F I+V+ YPE HP A Sbjct: 136 DLVKHIRKEHGDFFSIAVSGYPEGHPNAITKVQDEAELTESERERVIEMEDGLYVCRDGD 195 Query: 162 AQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAK 221 Q ++ LK KVDAGA+ ITQ FD Y F C + GI++ ++PGI+ + N K Sbjct: 196 FQKEMEYLKAKVDAGADLIITQMVFDAPVYGAFLKACKAYGINIPVVPGIMCIQNAGGFK 255 Query: 222 KFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAE 281 + R PA + + DD E + V + + L G HFYTLN + Sbjct: 256 RMTAFCKSRTPAALRAAVEAAGDDKEAIRKVAVEHGAQLCRDLQAAGAPGLHFYTLNLEK 315 Query: 282 MSYAICHTLGV 292 ++ AI L + Sbjct: 316 VTLAILDALNL 326 >UniRef50_A1W0I6 Methylenetetrahydrofolate reductase n=14 Tax=Campylobacter RepID=A1W0I6_CAMJJ Length = 282 Score = 318 bits (815), Expect = 2e-85, Method: Composition-based stats. Identities = 88/270 (32%), Positives = 143/270 (52%), Gaps = 3/270 (1%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG-ERDRTHSIIKGIKDRTG 82 + SFE FPPR E + L +D L L P F+SVT+GA T + I++ Sbjct: 3 SFSFEVFPPRKDENIKNLHAILDDLGQLSPNFISVTFGAGGSINSQNTLEVASLIQEEYQ 62 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG--SGKPEMYASDLVTLLK 140 + + HL CI ++ +++ I + + I+ALRGD+ K YASDL++ +K Sbjct: 63 IPSIVHLPCIHSSKEKITQILQKCKEKNLNQILALRGDICENLEKSKDFSYASDLISFIK 122 Query: 141 EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVS 200 + F+I A YPE H E+K+ D+ LK KV+AG ++ ITQ F+D E + F+ C Sbjct: 123 KQEYFEIYAACYPEKHNESKNFIEDIHYLKTKVNAGTDKLITQLFYDNEDFYTFKQNCAL 182 Query: 201 AGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDM 260 AGID+ I GI+P++N +Q K + + +IP ++ + +++A + G A D Sbjct: 183 AGIDIPIYAGIMPITNKRQVLKISQLCGAKIPPKFVKILEKYENNALALEDAGIAYACDQ 242 Query: 261 VKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + L GV H YT+N+++ + I + Sbjct: 243 IVDLITSGVDGIHLYTMNKSKAAIKIYEAV 272 >UniRef50_Q0FF75 Methylenetetrahydrofolate reductase n=1 Tax=Rhodobacterales bacterium HTCC2255 RepID=Q0FF75_9RHOB Length = 293 Score = 318 bits (815), Expect = 2e-85, Method: Composition-based stats. Identities = 116/276 (42%), Positives = 163/276 (59%), Gaps = 7/276 (2%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 +SFE FPPR + LW +I+ L L P F+SVTYGA+ R+ T S + I Sbjct: 7 DFGLSFEIFPPRNLKASFKLWRTIEVLEKLNPNFISVTYGADGSTRELTQSAVSVIAKEY 66 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYASDL 135 ++ A HLTC+ ++ E+ IA +Y G R IVALRGD P G + +L Sbjct: 67 NIDVAGHLTCVGSSKKEIMDIALEYGKAGARKIVALRGDSPEDQGSENHETDNFSSSVEL 126 Query: 136 VTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFR 195 + LK+ +F++ VAAYP VHP A+S ++DL LK K DAGA+ AITQFFFD E +LRFR Sbjct: 127 IASLKKNTNFELYVAAYPNVHPNAQSEKSDLDVLKAKFDAGADSAITQFFFDKEDFLRFR 186 Query: 196 DRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGAN 255 D+C +AGI IIPGILPV N+ + K FA + P WM++ ++ ++ E L+ Sbjct: 187 DKCNAAGIYQNIIPGILPVENWSKTKIFAKRCGMDAPQWMSKAYENCKNN-EEHDLLSQA 245 Query: 256 IAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 + +M L +EGV + HFYTLN +++ +C LG Sbjct: 246 LCTEMCNELMQEGVNNLHFYTLNDPKLTQKVCEALG 281 >UniRef50_C5L500 Methylenetetrahydrofolate reductase n=2 Tax=Perkinsus marinus ATCC 50983 RepID=C5L500_9ALVE Length = 631 Score = 315 bits (808), Expect = 1e-84, Method: Composition-based stats. Identities = 90/270 (33%), Positives = 135/270 (50%), Gaps = 16/270 (5%) Query: 37 MEQTLWNSIDRLSSLKPKFVSVTYGANSGER--DRTHSIIKGIKDRTGLEAAPHLTCIDA 94 Q L+ +DR++ L P ++ VT+GA ++T I + GL+ HLTC Sbjct: 2 GVQNLYERLDRMAELGPMWIDVTWGAGGSSSSSNKTFEICRNALTYHGLDVMMHLTCTQQ 61 Query: 95 TPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYASDLVTLLK-EVAD-FD 146 + +E+ + GIR+I+ALRGD P S + +A DLV ++ + D F Sbjct: 62 SVEEIDEVLDKCKEVGIRNILALRGDAPTQSSEWRACQGGFSHAVDLVRHIRGKYGDYFC 121 Query: 147 ISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVE 206 I+VA YPE H EA+S + DL++LK KVDAGA+ ITQ F+D E + +F GI V Sbjct: 122 IAVAGYPEGHLEAESIEEDLVHLKEKVDAGADLIITQLFYDTEVFFKFVAAVRKLGIQVP 181 Query: 207 IIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSR 266 I PGI+P+ ++ KK + ++P +A + + D + K +G I + M + Sbjct: 182 IFPGIMPIQSYSGFKKMTEFCKTKVPRAIADQLEQVKGDDQRVKDLGVEICVAMCSQIMS 241 Query: 267 EGVK------DFHFYTLNRAEMSYAICHTL 290 GV HFYTLN I L Sbjct: 242 YGVDHTHSSGGLHFYTLNLESSVCRIIERL 271 >UniRef50_A8XGR9 Methylenetetrahydrofolate reductase n=1 Tax=Caenorhabditis briggsae RepID=A8XGR9_CAEBR Length = 724 Score = 314 bits (806), Expect = 2e-84, Method: Composition-based stats. Identities = 89/297 (29%), Positives = 133/297 (44%), Gaps = 27/297 (9%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERD-----RTHSIIKGI 77 S EFFPPR ++RLS FV +T+ S + + SI + Sbjct: 106 PFFSLEFFPPRFVNGVPNFLERVERLSEGGSVFVDMTWHMGSDPANIDKVTSSSSIAASM 165 Query: 78 KDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG------------- 124 D G++ H+TC+ + G+R I+ALRGDLPPG Sbjct: 166 LDYCGVDTMLHMTCVQYNKADTLKHLEQAKAMGLRSILALRGDLPPGVCCGIVSNSFFIF 225 Query: 125 ------SGKPEMYASDLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAG 176 + A D++ ++E F I A YP HP+A S +ADL LK K DAG Sbjct: 226 MFQTELEDTNQFRALDMIRWIREEYGDYFSIGCAGYPLGHPQAPSYKADLQYLKAKCDAG 285 Query: 177 ANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMA 236 AN ITQ FF+ E++ +F C GI IIPGI+P+ ++ K+ A ++ + IP + Sbjct: 286 ANFVITQLFFEPETFEKFVADCREIGITKPIIPGIMPIMGYESIKRIAKLSQLEIPEHIL 345 Query: 237 QMFDGLDDDAETRKLVGANIAMDMVKILSREG-VKDFHFYTLNRAEMSYAICHTLGV 292 + + + D + + G ++M + L G H YT+NR I LG+ Sbjct: 346 EDLEPIKHDDDAVQKYGTERCIEMCRRLLDNGSAPSIHLYTMNREGSIREILKALGL 402 >UniRef50_A6UBB8 Methylenetetrahydrofolate reductase n=45 Tax=Rhizobiales RepID=A6UBB8_SINMW Length = 313 Score = 312 bits (801), Expect = 7e-84, Method: Composition-based stats. Identities = 116/286 (40%), Positives = 167/286 (58%), Gaps = 9/286 (3%) Query: 14 QSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSI 73 + + +G I SFE+FPP+ EME L+ ++ LS P FV+VTYGA + R+ + Sbjct: 6 PNAVDCRG-IRFSFEYFPPKNDEMEAQLFQTVTALSVFAPAFVTVTYGAGGSTKARSLTT 64 Query: 74 IKGIKDRTGL-EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK----- 127 +K + + A HLTC+ A ++ + ++ G+RH VALRGD G G Sbjct: 65 VKRMIGEMAIGNTAAHLTCVGAPKADVDAVVDEFVACGVRHFVALRGDPQGGIGSVYEPF 124 Query: 128 PEMY--ASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFF 185 P Y A+DLV L+ DF+ISV+AYPE HPE+ AD+ LKRKVD GA RA+TQFF Sbjct: 125 PGGYENAADLVKALRARGDFEISVSAYPEKHPESSDVAADIDMLKRKVDKGATRALTQFF 184 Query: 186 FDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDD 245 FD + + R+ +R AGI + ++PGILP++N Q +KFA + R+P + L+D Sbjct: 185 FDNDDFERYLERVRRAGIGIPVVPGILPINNLAQVQKFAGLCGARVPESLISRLGPLNDR 244 Query: 246 AETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 E R A+IA + + L R GV DFH YT+NR ++ A+C +G Sbjct: 245 PEERFREAAHIAAEQIADLVRRGVNDFHLYTMNRPQLVTAVCGLIG 290 >UniRef50_Q6CEM7 Methylenetetrahydrofolate reductase n=1 Tax=Yarrowia lipolytica RepID=Q6CEM7_YARLI Length = 625 Score = 311 bits (798), Expect = 1e-83, Method: Composition-based stats. Identities = 81/290 (27%), Positives = 133/290 (45%), Gaps = 21/290 (7%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + S EFFPP+T + R+++LKP F+++T+GA ++ I + Sbjct: 15 EKFFSLEFFPPKTQNGMANFRARLARMAALKPLFITITWGAGGSTAKKSLDIASECQS-M 73 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYASDL 135 GL+ HLTC + P + GI +I+ALRGD P G +A+DL Sbjct: 74 GLDVCLHLTCTNMDPALIDQALEAASKAGICNILALRGDPPRGEEYWQPASPEFQHAADL 133 Query: 136 VTLLKEVAD--FDISVAAYPEVHPEA-----KSAQADLLNLKRKVDAGANRAITQFFFDV 188 V +K+ F + VA YPE H + + DL LK KV+AGA+ ITQ F+D Sbjct: 134 VKYIKKKHGNKFCVGVAGYPEGHVDGSDASHQDFHHDLPYLKEKVEAGADFIITQMFYDD 193 Query: 189 ESYLRFRDRCVS---AGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGL-DD 244 +L + ++ IIPG++P++ + + A +++ +P + + Sbjct: 194 NKFLEYNKAVREFSPLLKNITIIPGLMPINTYTSFVRAARLSHASVPPAILDRIQAVPTG 253 Query: 245 DAETRKLVGANIAMDMVKILS---REGVKDFHFYTLNRAEMSYAICHTLG 291 + + K +G + D+V + + V+ FHFYTLN I G Sbjct: 254 NDQQVKDIGVEVVSDIVNDVYTKTNKTVRGFHFYTLNLERSVARILERSG 303 >UniRef50_C8W5Z9 Methylenetetrahydrofolate reductase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8W5Z9_DESAS Length = 294 Score = 311 bits (798), Expect = 1e-83, Method: Composition-based stats. Identities = 93/278 (33%), Positives = 146/278 (52%), Gaps = 7/278 (2%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G+ +SFEFFP R + +T +I+ L LKP FVSVT+GA ++ ++ ++K +K Sbjct: 9 TGKPTLSFEFFPARNEKAAETFNQTIEDLVELKPDFVSVTFGAGGSTKEGSYELVKKLKK 68 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG------KPEMYAS 133 LE +L DE+ + Y + GI +I+ALRGD P + + YAS Sbjct: 69 EKELEVVAYLAAFALKKDEINAVLNSYQDLGIENILALRGDPPKDADVTQVSAESFKYAS 128 Query: 134 DLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLR 193 +L + + F + VA YPE H EA S + D+ LK KVD G + I QFF+D + Sbjct: 129 ELAAFIHQNYSFCLGVAGYPEGHIEAPSLKKDIEYLKHKVDQGVDFIIAQFFYDNVCFFD 188 Query: 194 FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGL-DDDAETRKLV 252 FR+RC +GI++ ++PGI+PV + K + A +IP + + L + D + Sbjct: 189 FRERCQKSGINIPVLPGIMPVYSVKMMEMLAGSCGAKIPEKLRKGISELPEGDTKALVDF 248 Query: 253 GANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 G A + L +EG + HFYT++++E + I L Sbjct: 249 GIEYATGQCEELLKEGARGLHFYTMDKSESTVGIVKGL 286 >UniRef50_A4E8J9 Methylenetetrahydrofolate reductase n=1 Tax=Collinsella aerofaciens ATCC 25986 RepID=A4E8J9_9ACTN Length = 290 Score = 311 bits (797), Expect = 2e-83, Method: Composition-based stats. Identities = 91/282 (32%), Positives = 131/282 (46%), Gaps = 8/282 (2%) Query: 17 AEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG-ERDRTHSIIK 75 A QG +SFE FPP+ T L L P FVSVT A T I Sbjct: 10 AASQGTAPISFEMFPPKGELTLDTAREVAGNLCKLSPSFVSVTCSAGGSGNGAATAPIAH 69 Query: 76 GIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE------ 129 I + HLTC+ + ++ +Y G+ +I+ALRGDLP G+ + + Sbjct: 70 MITSEFDTPSVAHLTCVGRSHADIAAKIDEYRTAGVENILALRGDLPAGATEDDKPASDY 129 Query: 130 MYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVE 189 YA DL+ L A F + AAYPE H + + +LK+K DAGA+ +TQ FFD E Sbjct: 130 AYARDLIPEL-VDAGFCVGAAAYPEGHIACEDLNLSVEHLKQKQDAGASFFVTQLFFDNE 188 Query: 190 SYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETR 249 + RFR+ AGI V I GI+P Q + M +P+ + ++ ++D E+ Sbjct: 189 CFYRFRELADKAGITVPITAGIMPFMGKSQISRMVFMCGASLPSPVIKILAKYENDPESL 248 Query: 250 KLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 + G + A + L G H YT+NR ++ I LG Sbjct: 249 QAAGVDYAARQLCDLKEHGADGLHLYTMNRPAIAATIMERLG 290 >UniRef50_B3W8E2 Methylenetetrahydrofolate reductase n=15 Tax=Bacteria RepID=B3W8E2_LACCB Length = 290 Score = 310 bits (795), Expect = 3e-83, Method: Composition-based stats. Identities = 96/273 (35%), Positives = 142/273 (52%), Gaps = 6/273 (2%) Query: 20 QGQINVSFEFFPPRTSEMEQTL---WNSIDRLSSLKPKFVSVTYGANSGE-RDRTHSIIK 75 + +SFE FPPR + L N++D + P FVSVT+GAN + T + K Sbjct: 8 KDHQVISFEVFPPRKNASNIALTPILNTLDAVKEADPDFVSVTFGANGNKPHMGTLEVAK 67 Query: 76 GIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS--GKPEMYAS 133 IKD +E HL T +++ R + + GI +I+ALRGD+P YA Sbjct: 68 LIKDEFDMEPVAHLPAAQLTREQVDAELRGFQDAGIDNILALRGDIPKSGRVSNDFPYAC 127 Query: 134 DLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLR 193 DL+ + +V DF++ A YPE HPE+ +D+ +LK KVD+GA++ I+Q FFD + + R Sbjct: 128 DLIEHIHQVGDFNVVAACYPEKHPESPDVVSDIHHLKEKVDSGASQLISQLFFDNQVFYR 187 Query: 194 FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVG 253 FR+R AGI+V I GI+PV N Q ++ A M V +P M + E + G Sbjct: 188 FRERAQLAGINVPIEAGIMPVINEHQIERMATMAGVNLPPKFVAMMQHFSGNKEAMRDAG 247 Query: 254 ANIAMDMVKILSREGVKDFHFYTLNRAEMSYAI 286 A+D + L GV H YT++ + I Sbjct: 248 IAYAIDQIVDLLVHGVDGIHIYTMDNPTVVKRI 280 >UniRef50_C0EZI4 Methylenetetrahydrofolate reductase n=1 Tax=Eubacterium hallii DSM 3353 RepID=C0EZI4_9FIRM Length = 288 Score = 310 bits (795), Expect = 4e-83, Method: Composition-based stats. Identities = 88/283 (31%), Positives = 149/283 (52%), Gaps = 7/283 (2%) Query: 11 ALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRT 70 + + ++ +++SFE FPP+ E L+ ++D L L P+F+S TYGA +T Sbjct: 3 TMQTNPQDILKTLSLSFEVFPPKKWEDFPGLYETLDELKGLHPEFISCTYGAGGSNSKKT 62 Query: 71 HSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM 130 I I++ G+ + HLTC T D+L + ++ N GI ++ALRGD P + + Sbjct: 63 AEIASHIENELGIRSIAHLTCAALTEDKLLSTIENFKNAGIHSVLALRGDKPFDMSEEDF 122 Query: 131 ------YASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQF 184 + S+++ +LK+ A F ++ A YPE H EA S + DL LK KV+ GA+ I+Q Sbjct: 123 ANRQYKHPSEIIPILKK-AGFRVAAACYPEKHYEAPSMEEDLHWLKHKVEQGADALISQL 181 Query: 185 FFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDD 244 FFD +++ RF D GI V I GI+P+++ K +++ IP ++ + + Sbjct: 182 FFDNDAFYRFMDAADQKGITVPIHAGIMPITSAKMINTTINLSGASIPKALSDLIATYGE 241 Query: 245 DAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAIC 287 + + G A + L+ +G+ H YT+N +E + IC Sbjct: 242 NPSDMRKAGIEYAARQINDLAEQGMHYVHIYTMNHSETAKEIC 284 >UniRef50_A8ZV44 Methylenetetrahydrofolate reductase n=2 Tax=Desulfobacteraceae RepID=A8ZV44_DESOH Length = 292 Score = 309 bits (792), Expect = 8e-83, Method: Composition-based stats. Identities = 96/281 (34%), Positives = 144/281 (51%), Gaps = 6/281 (2%) Query: 16 LAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIK 75 + E + VSFEFFPPR + + T ID L+ LKP ++SVT+GA +D ++ +K Sbjct: 6 VYEKRKGPVVSFEFFPPRDEKAQGTFDAVIDELTPLKPDYLSVTFGAGGSTKDGSYQTVK 65 Query: 76 GIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG-----KPEM 130 + L ++ +PD + + Y GI I +RGD P + M Sbjct: 66 HLTADANLPVVAYVAGYGLSPDTIVNVLDRYRAIGIETIFVIRGDQPREPDFVSHPESFM 125 Query: 131 YASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES 190 YASDL+ + E DF + A YPE H +A+S + D+ LK KVD GA +TQ+F+D Sbjct: 126 YASDLIAFIAEQYDFSLGCAGYPEGHLQAESLEKDIEYLKLKVDNGARYVVTQYFYDNTF 185 Query: 191 YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQ-MFDGLDDDAETR 249 Y + ++C +AGI V IIPGI+PV K + + + IPA M + D D A+ Sbjct: 186 YFDYVEKCRAAGITVPIIPGIMPVYTLKMTRMLSKVCGSSIPASMETALADLADAPADRV 245 Query: 250 KLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 G A++ + L +GV HFYT++R+ + I L Sbjct: 246 VDFGIEKAVEQCRGLLEQGVPGLHFYTMDRSRSTREILTRL 286 >UniRef50_B8BVS6 Methylenetetrahydrofolate reductase n=1 Tax=Thalassiosira pseudonana RepID=B8BVS6_THAPS Length = 383 Score = 309 bits (791), Expect = 1e-82, Method: Composition-based stats. Identities = 93/295 (31%), Positives = 140/295 (47%), Gaps = 24/295 (8%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRL-SSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 VS E+FPPRT + + L +DR+ + + +T+GA D + + + Sbjct: 26 VSLEYFPPRTDQGVKNLHARMDRMLVNTNALYTDMTWGAGGSTADLSLELALHAHKTGHV 85 Query: 84 EAAPHLTCIDATPD-----ELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYA 132 HLTC + D + + ++ GIR+IVALRGD P G + A Sbjct: 86 SNM-HLTCTNMEKDGDPVKAVHDALQQAYDGGIRNIVALRGDPPEGEKEWTATEGGFSCA 144 Query: 133 SDLVTLLKEVAD--FDISVAAYPEVHPEAKS---------AQADLLNLKRKVDAGANRAI 181 DLV +++ F ISVA YPE HP S + ++ LK KVDAG + I Sbjct: 145 LDLVKYIRKTFGDKFGISVAGYPEGHPNRISQLSEEEDEDYKKEMDYLKEKVDAGGDFII 204 Query: 182 TQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDG 241 TQ FFD E + F + C + GI ++PG++ ++ + KK R+P + + D Sbjct: 205 TQMFFDAEVFKTFVNDCRTWGITCPVVPGLMCINAYPGFKKMTKFCKTRVPKSLEERMDA 264 Query: 242 LDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 + DDA+ K G ++ + L GVK HFYTLN ++ Y I LG+ GL Sbjct: 265 IKDDADAVKKFGVEFGAEISRNLLDSGVKILHFYTLNLEKVVYGITDELGITSGL 319 >UniRef50_A5EYC8 Methylenetetrahydrofolate reductase n=2 Tax=Cardiobacteriaceae RepID=A5EYC8_DICNV Length = 293 Score = 304 bits (780), Expect = 2e-81, Method: Composition-based stats. Identities = 102/282 (36%), Positives = 158/282 (56%), Gaps = 4/282 (1%) Query: 15 SLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSII 74 ++ E + +S EFFP T E+ L LS L ++ SVTYGA RD+T +++ Sbjct: 9 NMIEKSNSLRLSCEFFPAATKIGEKKLAEVRQALSFLNCEYYSVTYGAGGATRDQTIALV 68 Query: 75 KGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK--PEMYA 132 K + PH+TC+ + + ++ Y GI+H++ LRGD+P G + M A Sbjct: 69 KTLCREAERAVMPHITCVASHKRAIASLLAQYQKLGIKHLMLLRGDMPSGIYQLGDIMSA 128 Query: 133 SDLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES 190 DLV L+++ I VAAYPE HP+A++ Q DL+N K AGAN A+TQ+FF+ ++ Sbjct: 129 RDLVRLVRKQWGDSVHIVVAAYPETHPQAQTQQIDLINFYEKCAAGANEAVTQYFFNGDA 188 Query: 191 YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRK 250 YLRFRD V G+ + I+PGI+P++N+ + +F+D IP W+ + +D+ + Sbjct: 189 YLRFRDDVVKMGVSIPIVPGIMPITNYVRLARFSDNCGTEIPRWIRTRLESYQEDSASLL 248 Query: 251 LVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 GA++ + + L EGV HFYT+NRA+ I LG Sbjct: 249 DFGADVVSQLCQRLVSEGVPGLHFYTMNRADALIEIAKRLGW 290 >UniRef50_C7NEN8 Methylenetetrahydrofolate reductase n=8 Tax=Fusobacteriaceae RepID=C7NEN8_LEPBD Length = 291 Score = 304 bits (780), Expect = 2e-81, Method: Composition-based stats. Identities = 91/280 (32%), Positives = 148/280 (52%), Gaps = 10/280 (3%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 + + +SFE FPP + E+ L N L KP F+SVTYGA + T + IK+ Sbjct: 9 KKERLISFEIFPPNKNFSEEKLKNVTAELVEYKPDFISVTYGAGGKTKGGTIEMASHIKN 68 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYAS 133 E HLTC+ + E+ ++ + I++I+ALRGD+P G + YAS Sbjct: 69 NLKTEVLAHLTCVGSKKSEIHDYLQEAKSKNIKNILALRGDVPQGETEEIYDKGDYKYAS 128 Query: 134 DLVTLLK---EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES 190 +L++ L+ E DF I A YPE H E DL +LK KV+AG + +Q FFD + Sbjct: 129 ELISDLRKNSEFNDFSIGGAFYPETHYENNDL-VDLFHLKNKVEAGTDFLASQMFFDNDV 187 Query: 191 YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRK 250 +++F+++ I V +I GI+PV+N KQ K+ +++ +P + ++ + D+ E+ K Sbjct: 188 FVKFKEQAEKLDIKVPLIAGIMPVTNAKQIKRIIELSKCSVPEKLDKLLEKYGDNPESMK 247 Query: 251 LVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 G A + + L G+K H YT+N+ E++ I + Sbjct: 248 KAGIMYASEQIIELLAYGIKGIHIYTMNKPEIAKEIMKNI 287 >UniRef50_A8PLM8 Methylenetetrahydrofolate reductase n=1 Tax=Rickettsiella grylli RepID=A8PLM8_9COXI Length = 281 Score = 303 bits (776), Expect = 6e-81, Method: Composition-based stats. Identities = 101/278 (36%), Positives = 164/278 (58%), Gaps = 5/278 (1%) Query: 17 AEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKG 76 ++ + N SFE FPP+T + L+ + LS LKP + S+T+GA + ++ +IK Sbjct: 1 MQLCQKFNFSFEVFPPQTHRGLKNLYATRQELSKLKPNYFSITFGAGGAIQHQSLLVIKQ 60 Query: 77 IKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK--PEMYASD 134 G+ A PH++C++ T L + +Y G++ ++ ++GDLP K YA++ Sbjct: 61 FVKD-GIAATPHISCVNMTYPRLYDLLMEYQQLGVKQLLVIQGDLPKEVPKLSEFNYANE 119 Query: 135 LVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYL 192 L++ ++++ F I VAAYPE HP+A S + D+ N KRK++AGAN AITQFFF+ ++Y Sbjct: 120 LISAIRKITGNYFHIIVAAYPEFHPQAFSPRKDIENFKRKIEAGANSAITQFFFNSDAYF 179 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV 252 RF + C A I + I+PGI P+ N+++ +F+ IP W+ + L +D ++ + V Sbjct: 180 RFIEACEKASIHIPIVPGITPIINYQKLIQFSTACGAEIPLWLRKHLAMLSNDPQSLQEV 239 Query: 253 GANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 G + + L + GVK+FHFYTLNRA +Y I L Sbjct: 240 GIEFVTKLCQHLLQNGVKEFHFYTLNRANPTYRIIENL 277 >UniRef50_Q4Q0B9 Methylenetetrahydrofolate reductase n=3 Tax=Leishmania RepID=Q4Q0B9_LEIMA Length = 309 Score = 302 bits (773), Expect = 1e-80, Method: Composition-based stats. Identities = 84/294 (28%), Positives = 139/294 (47%), Gaps = 20/294 (6%) Query: 17 AEVQGQINVSFEFFPPRTSEMEQTLWNS-IDRLSSLKPKFVSVTYGANSGERDRTHSIIK 75 AE + N S+E +PPR+ + E+ + + P F+ +T+GA T + K Sbjct: 11 AEDASKWNTSYELYPPRSEKAEEDMMKVLVPNFMHQSPVFLDLTWGAGGRTSGTTMRLCK 70 Query: 76 GIKDRTGLEAA-PHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG---KPEMY 131 ++ H+TC + ++ +GIR+I+ALRGD P G P+ + Sbjct: 71 DLQHAHPDTPINMHITCTNTPKGLIKETLEFAKTHGIRNILALRGDPPSGEEFQVDPDGF 130 Query: 132 AS--DLVTLLKEVAD--FDISVAAYPEVHPEA---------KSAQADLLNLKRKVDAGAN 178 A DLV +++ F +SVA YPE HP + Q +L LK KVDAGA+ Sbjct: 131 ACARDLVRYIRDTYGDYFCVSVAGYPEGHPSRIAENGTISHEDHQKELEYLKEKVDAGAS 190 Query: 179 RAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQM 238 ITQ F+D Y++F RC GI V I+ G+LP++ + + + +P+ + + Sbjct: 191 FIITQLFYDASLYVKFVKRCREVGITVPILAGLLPITTYAGFVRMVSLCKTSVPSDVKKR 250 Query: 239 FDGLDDDAETRKLVGANIAMDMVKILSREGV--KDFHFYTLNRAEMSYAICHTL 290 + L ++ + K G + M++ + G+ HFYTLN + + I L Sbjct: 251 VEELKENPDGLKEYGVEQCVQMIECIRASGLDYHHLHFYTLNNSAQIFKILKRL 304 >UniRef50_B7GRV7 Methylenetetrahydrofolate reductase n=16 Tax=Bifidobacteriaceae RepID=B7GRV7_BIFLI Length = 284 Score = 300 bits (769), Expect = 4e-80, Method: Composition-based stats. Identities = 87/272 (31%), Positives = 137/272 (50%), Gaps = 4/272 (1%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANS-GERDRTHSIIKGIKDRT 81 S E FPP+ + T+++++D L L P F+SVTYG + +R T I I Sbjct: 4 PMFSLEVFPPKRNAPVDTIYDTLDGLEGLNPDFISVTYGHGTHSDRTATARIAHTISKEY 63 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG--KPEMYASDLVTLL 139 G+ A HLT + + ++ + G+ ++ALRGD G +ASDLV+ + Sbjct: 64 GIPAVAHLTALYSDKAKIDEALDMFEQAGVSAVLALRGDYIDGERLVGDFNHASDLVSYI 123 Query: 140 KEV-ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRC 198 + + D + A YPE H ++ S D+ NLK KVDAG R I+Q F+D E + RF D+ Sbjct: 124 RSMKPDLTVFGACYPEGHYQSGSLDQDIENLKIKVDAGVTRLISQLFYDNEDFYRFLDKA 183 Query: 199 VSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAM 258 +AGI V I GI+PV K ++ A+ RIP + + + +DD ++ + G A Sbjct: 184 RAAGITVPIEAGIMPVRGAKSVRRMAERNASRIPDKLDALLNRWEDDIQSLRTAGILYAS 243 Query: 259 DMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + + L GV H Y++N + I + Sbjct: 244 EQIADLVAHGVDGVHLYSMNHPATTRRIWRNV 275 >UniRef50_B9Z0I7 Methylenetetrahydrofolate reductase n=1 Tax=Lutiella nitroferrum 2002 RepID=B9Z0I7_9NEIS Length = 287 Score = 300 bits (768), Expect = 4e-80, Method: Composition-based stats. Identities = 103/274 (37%), Positives = 160/274 (58%), Gaps = 5/274 (1%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 I S E +PP + + + L ++ RL++L P++ SVTYGA R+RT ++ + G Sbjct: 3 IPFSLELYPPTSPQSARQLERALPRLAALGPEYFSVTYGAGGCTRERTLDLVGQLH-EAG 61 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK--PEMYASDLVTLLK 140 APHL+ + A E+ + Y G+R + ALRGD P G G YASDLV ++ Sbjct: 62 HTVAPHLSGVGAERAEVAELCAHYRRLGVRRLFALRGDTPSGMGSRGDFAYASDLVRFIR 121 Query: 141 EVA--DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRC 198 E + DF I VAAYPEVHP+AKS ADL L+ K +AGAN A+TQ+FF+ +++L RD C Sbjct: 122 EHSGDDFRIEVAAYPEVHPQAKSPAADLAALRVKQEAGANAAVTQYFFNTDAFLYLRDSC 181 Query: 199 VSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAM 258 +AGI + ++PG+LP++ F+ + A+ + +P W+ + + L DD + G ++ Sbjct: 182 HAAGITLPLVPGVLPLTRFRSTAQRAEARGIEMPRWIYRKMESLADDTAAVRAFGLDVTA 241 Query: 259 DMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 + L EGV HF++LN+ + A+ LG+ Sbjct: 242 RQCERLIAEGVPALHFFSLNQIDAIEALHARLGL 275 >UniRef50_Q4P1E8 Methylenetetrahydrofolate reductase n=1 Tax=Ustilago maydis RepID=Q4P1E8_USTMA Length = 684 Score = 300 bits (768), Expect = 5e-80, Method: Composition-based stats. Identities = 89/321 (27%), Positives = 142/321 (44%), Gaps = 50/321 (15%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLS-SLKPKFVSVTYGANSGERDRTHSIIKGIK------ 78 SFEFFPP+TS+ L+N I R+ +L+P ++ VT+GA ++ + I+ Sbjct: 41 SFEFFPPKTSQGLANLYNRIARMHVNLEPSWIHVTWGAGGTTGGKSLELAGRIQKGKLDP 100 Query: 79 --------------------------------DRTGLEAAPHLTCIDATPDELRTIARDY 106 + HLTC + L Sbjct: 101 DVELVQTEINHIGSGTQQHIENVKGGQEWEQERADPCDVCLHLTCTNVEKSSLDQTLDTA 160 Query: 107 WNNGIRHIVALRGDLPPGS------GKPEMYASDLVTLLKEVAD--FDISVAAYPEVHPE 158 GI++I+ALRGD P G K +A+DLV +++ F I VA YPE H + Sbjct: 161 KRLGIKNILALRGDPPRGEEYWIAADKRFQHATDLVRYIRQRHGNYFCIGVAGYPEGHAD 220 Query: 159 --AKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSN 216 + DL LK K DAGA ITQ F+DV+ +L + C GI + I+PGI+P+ N Sbjct: 221 YVDRDVNRDLRYLKDKQDAGAQYIITQLFYDVDRFLEWYRDCREIGITIPILPGIMPIQN 280 Query: 217 FKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMV-KILSREGVKDFHFY 275 + ++ ++ V++P + + + D K G ++++ MV +I V+ FH Sbjct: 281 YSSFRRMTNLCKVQVPQLILDALEPIKSDDAAVKEYGVSLSIHMVGRIFLETDVRGFHLC 340 Query: 276 TLNRAEMSYAICHTLGVRPGL 296 +LN + I LG + + Sbjct: 341 SLNLEKSIERILEGLGWKTDV 361 >UniRef50_C4ZCX7 Methylenetetrahydrofolate reductase n=2 Tax=Firmicutes RepID=C4ZCX7_EUBR3 Length = 288 Score = 299 bits (766), Expect = 7e-80, Method: Composition-based stats. Identities = 86/272 (31%), Positives = 140/272 (51%), Gaps = 5/272 (1%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG-ERDRTHSIIKGIKDRTG 82 ++SFE FPP+ E + + ++ L P+++SVT+GA ++T I K IK++ Sbjct: 13 SLSFEIFPPKKEEDFKNIDEMLEILCDCHPEYISVTFGAGGSSNNNKTIEIAKKIKNQYN 72 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG--KPEMYASDLVTLLK 140 +E HLTC+ E+ R GI +I+ALRGD P + ++ASDL+ +K Sbjct: 73 VEPVVHLTCLCYNKAEIDEFTRQLSYEGIENILALRGDRNPNVPAKEDFLHASDLIKYIK 132 Query: 141 EVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRC 198 + F I+ A YP++HPEA D+ NLK+KVDAGA ++Q FFD +++ F + C Sbjct: 133 DTTGDQFCIAGACYPDIHPEAADKVDDIKNLKKKVDAGAELLLSQLFFDNDTFFNFAEDC 192 Query: 199 VSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAM 258 AGI+V +IPGI+P N Q ++ M + P ++ D+ G + Sbjct: 193 RLAGINVPVIPGIMPCINAAQIQRMVTMCGAKFPEKFQKIVHRYGDNKAALFDAGMSYCE 252 Query: 259 DMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + L V+ H YT+N ++ + + Sbjct: 253 SQIIELLANDVEGIHLYTMNNVRVAKRLTEGI 284 >UniRef50_Q058D8 Methylenetetrahydrofolate reductase n=1 Tax=Buchnera aphidicola str. Cc (Cinara cedri) RepID=Q058D8_BUCCC Length = 293 Score = 299 bits (766), Expect = 8e-80, Method: Composition-based stats. Identities = 115/287 (40%), Positives = 170/287 (59%) Query: 6 ASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG 65 + + + ++ +I +SFE FPP +++ L+ SI L+ P+F SVT Sbjct: 6 KNIKKLYTDKIYNLKNKIKISFEVFPPGDIFLQKKLFKSIKILNQFNPEFFSVTNSTKIN 65 Query: 66 ERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS 125 D+T I+K I++ H T I ++ IA YWN+GI++I+ALRGDLP Sbjct: 66 SFDQTFFIVKKIRELIHCTVFAHFTTIGCNELKIEKIAHRYWNHGIKNIIALRGDLPVLY 125 Query: 126 GKPEMYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFF 185 + +YA DL+ LL + F I VAAYPE HPE+K+ Q DL NL+ K+D G +AITQFF Sbjct: 126 SRKIIYAVDLIKLLNSINKFKIFVAAYPEGHPESKNIQEDLNNLRNKLDLGVKQAITQFF 185 Query: 186 FDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDD 245 F+++ +L+FRD C S G++V +IPGILP+ NF+Q KKF++MTNV +P W+ F +D Sbjct: 186 FNIDKFLKFRDTCFSLGLNVNLIPGILPILNFEQLKKFSNMTNVEVPKWILNTFHRHKND 245 Query: 246 AETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 + I +D++ L EG+ FH YTLN+ + IC LG+ Sbjct: 246 EKKCISCSVYIIIDLIIKLYNEGITHFHLYTLNQPHLISLICQRLGL 292 >UniRef50_Q5M088 Methylenetetrahydrofolate reductase n=47 Tax=Firmicutes RepID=Q5M088_STRT1 Length = 311 Score = 297 bits (762), Expect = 2e-79, Method: Composition-based stats. Identities = 92/294 (31%), Positives = 148/294 (50%), Gaps = 5/294 (1%) Query: 1 MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY 60 + + Q+ + ++SFE FPP + + + ++D + P F+SVT Sbjct: 4 IKMLLSQQKSKTKKVKLMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTA 63 Query: 61 GANSGE-RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRG 119 N ++ T + I++ + HL I + +++ R+ G+ I+ALRG Sbjct: 64 SNNKYNIKETTVPLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRG 123 Query: 120 DLPPGSG--KPEMYASDLVTLLK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAG 176 D+ PG K YA+DL+ +K E +FDI A YPE HP++ + +D+ NLK+KVDAG Sbjct: 124 DIIPGVEPLKDFRYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAG 183 Query: 177 ANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMT-NVRIPAWM 235 + +TQ FFD E + F+D+C AGIDV I GI+P+ N QA + N+ +P Sbjct: 184 CSSLVTQLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKF 243 Query: 236 AQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHT 289 + D + D E+ + G A+D + L + V H YT+N AE + I Sbjct: 244 RAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEA 297 >UniRef50_B7GB47 Methylenetetrahydrofolate reductase (Fragment) n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B7GB47_PHATR Length = 376 Score = 296 bits (758), Expect = 7e-79, Method: Composition-based stats. Identities = 95/340 (27%), Positives = 144/340 (42%), Gaps = 70/340 (20%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSS-LKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G+ VS E+FPPRT+E Q L + R+ L+P F +T+GA + + + + Sbjct: 38 GKPFVSLEYFPPRTAEGVQNLHARMHRMRDTLQPAFTDMTWGAGGSTAELSLQLALYAHN 97 Query: 80 RTGLEAAPHLTCIDAT---------------------------PDELRTIARDYWNNGIR 112 TG A H+TC + + LR + + GIR Sbjct: 98 -TGHVANLHMTCTNLDSGKSSTSTSSSSEHNGNASDDVASADPRETLRRALQQAHDGGIR 156 Query: 113 HIVALRGDLPPGSGKP------EMYASDLVTLLKEVAD----FDISVAAYPEVHPEA--- 159 ++VALRGD P G A DLV ++ + D F ++VA YPE HP A Sbjct: 157 NLVALRGDPPAGQETWTATEGGFTCALDLVEFIRSLPDIGADFHLAVAGYPEGHPNAISE 216 Query: 160 ---------------------------KSAQADLLNLKRKVDAGANRAITQFFFDVESYL 192 ++ LK+KVDAG + +TQ FFD +L Sbjct: 217 IADPTTLTAAEAARASVTDGKTYCCLDADYHKEMEYLKKKVDAGGDMIMTQMFFDAAVFL 276 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV 252 +F + C + GI V I+PG++ ++ + K A R+P + + + DDA K Sbjct: 277 QFVEDCRAWGITVPIVPGLMCINAYAGFVKMAKFCKTRVPETLRARMEAIKDDAAAVKAF 336 Query: 253 GANIAMDMVKILSREG-VKDFHFYTLNRAEMSYAICHTLG 291 G ++M + L G V HFYTLN ++ Y + LG Sbjct: 337 GVEFGVEMCRTLLASGHVSVLHFYTLNLEKVVYGVLDALG 376 >UniRef50_A0JXH6 Methylenetetrahydrofolate reductase n=6 Tax=Micrococcineae RepID=A0JXH6_ARTS2 Length = 323 Score = 294 bits (754), Expect = 2e-78, Method: Composition-based stats. Identities = 96/288 (33%), Positives = 143/288 (49%), Gaps = 16/288 (5%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 + +S+E FPPR+ ++LW +I L + P +VSVTYGA+ RD +I + T Sbjct: 19 VALSYELFPPRSPAAAESLWTTIGELEATDPDYVSVTYGASGSNRDTAVELINRLLLETT 78 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE----MYASDLVTL 138 L HLTC+ TP+EL I + + G+R I+ALRGD P P YA DL+ L Sbjct: 79 LRPLAHLTCVGNTPEELSEIIGELLDVGVRGILALRGDRPKDGAAPVSGSLRYAQDLIEL 138 Query: 139 LKEV----------ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDV 188 ++ V + VAAYP HPE+ + D+ L K +GA+ AITQ FF Sbjct: 139 IRRVEQRRSALLCAGKVAVGVAAYPTRHPESPTEAHDVEVLLAKQRSGADFAITQVFFHT 198 Query: 189 ESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAET 248 E Y R AG+ + IIPG++P+++ ++ + A++T V + D DAE Sbjct: 199 EQYADLITRARRAGVTIPIIPGVMPLTSVRRLNRLAELTGVEPAPELMARLAAADTDAE- 257 Query: 249 RKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV-RPG 295 R+L+G +D+ G H YT N + + L + RP Sbjct: 258 RRLIGVRATVDLANAALDAGAPGIHLYTFNEHACALEVLDKLALPRPA 305 >UniRef50_O74927 Methylenetetrahydrofolate reductase 2 n=2 Tax=Schizosaccharomyces RepID=MTHR2_SCHPO Length = 641 Score = 294 bits (754), Expect = 2e-78, Method: Composition-based stats. Identities = 91/294 (30%), Positives = 143/294 (48%), Gaps = 22/294 (7%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSS-LKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G SFE+FPP+T+ + L + I R+S + P F SVT+G + + + K ++ Sbjct: 13 GNAFYSFEYFPPKTTVGLENLSSRITRMSRNMMPLFSSVTWGTAGSTAEVSIYLAKMLEQ 72 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM------YAS 133 + A HLTC + + GIR+I+ALRGD P S E +A Sbjct: 73 HHKIPACLHLTCTNVDKAIIDKALETAKEYGIRNILALRGDPPLNSDHWEGKVSEFEHAV 132 Query: 134 DLVTLLKEVAD--FDISVAAYPEVHPE------AKSAQADLLNLKRKVDAGANRAITQFF 185 DLV ++E F I VAAYPE H + +K D+ L KV+AGA+ ITQ F Sbjct: 133 DLVRYIREKYGDYFCIGVAAYPEGHVDSNVPELSKDPLRDIPFLIEKVEAGADFIITQIF 192 Query: 186 FDVESYLRF----RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDG 241 ++ E++++F R+ +A ++ IIP I+P+ ++ K+ + +P+ + Q + Sbjct: 193 YEPEAFIKFENFVRNHSSNALRNIPIIPAIMPIQSYGSLKRMTRLCGCSVPSSLMQRLNA 252 Query: 242 LDDDAETRKLVGANIAMDMVKILSR--EG-VKDFHFYTLNRAEMSYAICHTLGV 292 D E K +G +DM+K + +G V FHF TLN I G+ Sbjct: 253 AKPDDEAIKNIGVEHIVDMIKKIMDNVQGRVHGFHFCTLNLERSVALILKNSGL 306 >UniRef50_C8NQ26 Methylenetetrahydrofolate reductase n=20 Tax=Corynebacterineae RepID=C8NQ26_COREF Length = 326 Score = 294 bits (752), Expect = 4e-78, Method: Composition-based stats. Identities = 99/295 (33%), Positives = 149/295 (50%), Gaps = 19/295 (6%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 V G++ S EF PPR E L+ + + L FVSVTYGA R+RT + + + Sbjct: 22 VPGRVPFSVEFMPPRDDAAENRLYRAAEVFHDLGASFVSVTYGAGGSTRERTARVARRLS 81 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG-------SGKPEMY 131 + L HLT +D T EL+ I R Y G+ +++ALRGD P S Y Sbjct: 82 RQ-PLTTLVHLTLVDHTIAELQEILRGYAELGLTNLLALRGDPPGDPLGEWATSEGGMSY 140 Query: 132 ASDLVTLLK---EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDV 188 A +L+ ++K E + FDI +A++PE H A S + D K+ AGA +ITQ FFDV Sbjct: 141 ALELIEMIKNSPEFSHFDIGIASFPEGHYRAGSLENDTRYTLAKLRAGAEYSITQMFFDV 200 Query: 189 ESYLRFRDRCVSA---GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDD 245 E +LR RDR V+A IIPG++P+++ + ++ +++ +P + + + Sbjct: 201 EDFLRLRDRLVAADPIHGAKPIIPGLMPITSLRSVRRQVELSGSTLPRALEEKLLRAANG 260 Query: 246 AE-----TRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPG 295 E + VG +M + L EGV D HF TLN + + H LG+ P Sbjct: 261 DEEANRNEIRKVGIETTSEMAERLIAEGVPDLHFMTLNFTRATQEVLHNLGMAPA 315 >UniRef50_A3H552 Methylenetetrahydrofolate reductase (Fragment) n=2 Tax=Vibrio cholerae RepID=A3H552_VIBCH Length = 208 Score = 292 bits (747), Expect = 1e-77, Method: Composition-based stats. Identities = 166/206 (80%), Positives = 186/206 (90%) Query: 89 LTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVADFDIS 148 LTCIDAT DEL IA DYW+NGI++IVALRGD+P G GKPEMYASDLVTLLK DFDIS Sbjct: 1 LTCIDATRDELIQIADDYWHNGIQNIVALRGDIPAGGGKPEMYASDLVTLLKSRHDFDIS 60 Query: 149 VAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEII 208 VAA+PEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV+AGIDVEI+ Sbjct: 61 VAAFPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVAAGIDVEIV 120 Query: 209 PGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREG 268 PGILPVSNFKQA +FA NV++P WM + F+GL+DD TR+LVGA+ A+DMV++L REG Sbjct: 121 PGILPVSNFKQASRFAAQNNVKVPNWMVKQFEGLEDDPVTRQLVGASQAIDMVRVLCREG 180 Query: 269 VKDFHFYTLNRAEMSYAICHTLGVRP 294 VKDFHFYTLNRAEM+YA+CHTLGVRP Sbjct: 181 VKDFHFYTLNRAEMTYALCHTLGVRP 206 >UniRef50_C9L8P5 Methylenetetrahydrofolate reductase n=1 Tax=Blautia hansenii DSM 20583 RepID=C9L8P5_RUMHA Length = 311 Score = 289 bits (740), Expect = 9e-77, Method: Composition-based stats. Identities = 91/307 (29%), Positives = 147/307 (47%), Gaps = 23/307 (7%) Query: 9 RDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERD 68 R L + ++ ++ +SFE FPP+T + + L +I+ L KP+++S TYGA Sbjct: 3 RYKLMKLSDAMREKMLLSFELFPPKTDKGMENLPGTIEHLCKYKPEYISCTYGAGGTNVG 62 Query: 69 RTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP---PGS 125 + + K IKD G H TCI T + ++ ++Y +NG+ H++ALRGDLP G+ Sbjct: 63 KNMDVCKMIKD-AGTIPVTHFTCIGNTAEGIKDQLQNYLDNGVDHMLALRGDLPFGWTGT 121 Query: 126 GKPEMYASDLVTLLK-EVAD-FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQ 183 G YA+DLV ++ E D +I+VA PE H +S +AD+ LK+K D GA+ +TQ Sbjct: 122 GGDFAYATDLVAYVRKEFGDKIEIAVAGSPEGHISCRSLEADIAVLKQKQDNGADYIMTQ 181 Query: 184 FFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNVRIPAWMAQMF--- 239 +D+E + + D AGI + + GI+P+ + A +P + ++ Sbjct: 182 LCWDMEQFKYWLDAIRCAGITMPVDVGIMPILDQAATINMALSRNACVMPRELCEIISKN 241 Query: 240 ---------DGLDDDAE----TRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAI 286 D D D E K G + + G+ H Y LN+ + I Sbjct: 242 WIFPNPFVQDPFDADVEGKKARFKEAGIEYTIRQIDEYRACGIDGIHLYALNKWKDVSEI 301 Query: 287 CHTLGVR 293 G+R Sbjct: 302 IDRSGLR 308 >UniRef50_D1U6W4 Methylenetetrahydrofolate reductase n=1 Tax=Desulfovibrio aespoeensis Aspo-2 RepID=D1U6W4_9DELT Length = 290 Score = 289 bits (739), Expect = 1e-76, Method: Composition-based stats. Identities = 86/287 (29%), Positives = 130/287 (45%), Gaps = 6/287 (2%) Query: 14 QSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSI 73 L + VS E PPR ++ L +KP F +VT GA T Sbjct: 4 PDLIGSLSRPFVSIELLPPRREAELAGFGQAVQALKGMKPLFAAVTCGAGGRGAVGTLET 63 Query: 74 IKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG---KPEM 130 + + + G PHLTC+ P L GIR+++A+RGD P G K Sbjct: 64 ARDLAEDHGFTVMPHLTCVHVPPAALPGQLDALRTCGIRNVLAVRGDFPAGMEPVSKGFR 123 Query: 131 YASDLVTLLKEV-ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVE 189 +ASDLV ++++ D + VAAYP+ HP+++S D+ L+ K+D GA+ A+TQ FFD Sbjct: 124 HASDLVARVRQLAPDMAVGVAAYPDGHPDSRSILEDIGFLRFKLDQGASFAVTQLFFDNR 183 Query: 190 SYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDG--LDDDAE 247 Y DR + G IIP ILP+ + Q K+ ++ + +P + + D Sbjct: 184 RYFDMVDRLAAMGCTKPIIPSILPIRSLGQIKRVMELCDAPVPGTLLADIEAAHAKDGDA 243 Query: 248 TRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRP 294 + G A + L +G H Y NRA+M + G+ P Sbjct: 244 GVRRYGVAQAASQLSELLEQGAPGVHLYPFNRADMCLEVVQRAGLLP 290 >UniRef50_C2EUU9 Methylenetetrahydrofolate reductase n=2 Tax=Lactobacillus RepID=C2EUU9_9LACO Length = 281 Score = 287 bits (734), Expect = 4e-76, Method: Composition-based stats. Identities = 84/272 (30%), Positives = 134/272 (49%), Gaps = 4/272 (1%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE-RDRTHSIIKGIKDRTG 82 +S+E FPP ++ L + L L P F+SVT +N+ + T + +++ Sbjct: 3 TLSYEVFPPNSTVGINHLNQVLTSLRDLSPDFISVTCNSNTKQLAHETVRVADYVENDCQ 62 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP--EMYASDLVTLLK 140 + A HL + +++ I + ++ LRGD P K +ASDL+ +K Sbjct: 63 VPAMAHLPAWYLSREDVDRILEQLRVCHVDRVLVLRGDERPKLEKKTDFAHASDLIAYIK 122 Query: 141 E-VADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199 + DF I+ A YPE HPE+ S ++ +LK KV++G ++ ITQ F D SY RFR+ C Sbjct: 123 QNYPDFQITGACYPEKHPESLSMVDEIQHLKLKVESGCDQIITQLFLDNHSYYRFRELCA 182 Query: 200 SAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMD 259 GIDV II GI+PV N +QA + + V +P + D + K G A+D Sbjct: 183 IGGIDVPIIAGIMPVVNERQANRILRTSAVTVPEKFKDILAKYHDHPQALKQAGITYAID 242 Query: 260 MVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 + L V H YT+N ++ + + +G Sbjct: 243 QIVDLVTNDVSGIHLYTMNHSDTARQVKQNIG 274 >UniRef50_C6BZ56 Methylenetetrahydrofolate reductase n=1 Tax=Desulfovibrio salexigens DSM 2638 RepID=C6BZ56_DESAD Length = 293 Score = 287 bits (734), Expect = 5e-76, Method: Composition-based stats. Identities = 83/280 (29%), Positives = 121/280 (43%), Gaps = 8/280 (2%) Query: 18 EVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGI 77 GQ SFEFFPP+ RL++LKP F SVTYGA D + I + Sbjct: 8 NEAGQF-FSFEFFPPKDKSTWPVFMERAARLAALKPLFASVTYGAGGTSHDNSLEICSLL 66 Query: 78 KDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP----EMYAS 133 K G++ HLTC+ A+ + G+ I+AL GD + +AS Sbjct: 67 KKDMGIDILAHLTCVGASEQSIDEFVSRLCETGVSDILALGGDGVKDANGEGQSRFFHAS 126 Query: 134 DLVTLL-KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYL 192 DLV + + ++ I+VA YP HPE+ S D+ K+ GA+ +TQ FFD Y Sbjct: 127 DLVEYVDDKFSEVGIAVAGYPGGHPESPSIAKDIEIHNSKLSKGADFTMTQLFFDNRLYF 186 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGL--DDDAETRK 250 + DR G +IPG+LP+ + ++ + IP + + E Sbjct: 187 DYVDRLAELGSTAPVIPGVLPIQSLSSLRRIMSLCGAGIPGDLYCGVEKAFEKGGDEAVM 246 Query: 251 LVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 G + A + L G H Y+LNRA M + L Sbjct: 247 EFGFDFARKQISDLLDRGAPGVHIYSLNRAAMCERLITDL 286 >UniRef50_C4R2Q6 Methylenetetrahydrofolate reductase n=6 Tax=Saccharomycetaceae RepID=C4R2Q6_PICPG Length = 603 Score = 283 bits (724), Expect = 6e-75, Method: Composition-based stats. Identities = 82/274 (29%), Positives = 135/274 (49%), Gaps = 15/274 (5%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 SFEFF P+T++ Q L++ +DR+ +L P+F+ +T+ A + T +I + G Sbjct: 18 PTFSFEFFTPKTAQGVQNLYDRMDRMYNLSPQFIDITWNAGGRSSNLTCEMINTAQTVLG 77 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP---EMYASDLVTLL 139 LE HLTC + T + + + +++G ++I+ALRGD P + YA DL+ + Sbjct: 78 LETCMHLTCTNMTLEVIDEALKSAYDSGCQNILALRGDPPLDGSESTGCFRYAKDLIKHI 137 Query: 140 KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199 KE HP+ + LK K DAG + ITQ F+DVE ++ + + Sbjct: 138 KEKY-----------GHPDEPDVDRLIEILKEKQDAGGDFMITQMFYDVEQFITWCKKVR 186 Query: 200 SAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMD 259 GI + IIPGI+P+S + + A + +P+W + D DD + +G + D Sbjct: 187 DYGITIPIIPGIMPISTYASFSRRAKWCQINVPSWFQKQLDASKDDDSEVRCLGTQLVAD 246 Query: 260 MVKILSREG-VKDFHFYTLNRAEMSYAICHTLGV 292 M L G V HFYT+N + + + L + Sbjct: 247 MCLKLVESGYVNHLHFYTMNLEKSTIMVLEKLQL 280 >UniRef50_A8QAM7 Methylenetetrahydrofolate reductase n=1 Tax=Malassezia globosa CBS 7966 RepID=A8QAM7_MALGO Length = 589 Score = 282 bits (721), Expect = 1e-74, Method: Composition-based stats. Identities = 92/317 (29%), Positives = 150/317 (47%), Gaps = 31/317 (9%) Query: 6 ASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSS-LKPKFVSVTYGANS 64 A + LN S + S EFFPPRT+ L + R+S L+P +V VT+G Sbjct: 10 ARIDEKLNDSTQDA---YVWSLEFFPPRTALGLANLCARVARMSEALQPGWVHVTWGTGG 66 Query: 65 GERDRTHSIIKGIK----------------DRTGLEAAPHLTCIDATPDELRTIARDYWN 108 RD + + ++ + + HLTC + L + Sbjct: 67 STRDASMELAARVQKGVYDPLEDYTNVKERRKGACDVCLHLTCTNVERAYLDATLDEARQ 126 Query: 109 NGIRHIVALRGDLPPGS------GKPEMYASDLVTLLKEVAD--FDISVAAYPEVHPEAK 160 GIR+I+ALRGD P + A+DLV ++E F I VA YPE + Sbjct: 127 IGIRNILALRGDPPRSDEYWVATDQRLQNATDLVRYIRERHGDYFCIGVAGYPEGLKQGI 186 Query: 161 S--AQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFK 218 + D+ LK K +AGA+ +TQ F+DV++ +R+ C +AGI + IIPGI+P+ N+ Sbjct: 187 DCDMRHDIKVLKAKQEAGAHFIVTQLFYDVDALVRWTKECRAAGITIPIIPGIMPIQNYT 246 Query: 219 QAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSRE-GVKDFHFYTL 277 ++ A++ V P + + + + D K G ++++DM+K + + G++ FH YTL Sbjct: 247 MFRRMANLCGVHTPEDVLEQLEPIKMDDAKVKEHGIHLSIDMIKSIREQTGIRAFHLYTL 306 Query: 278 NRAEMSYAICHTLGVRP 294 N + + + L P Sbjct: 307 NLEKSATCVIKVLADVP 323 >UniRef50_C0QAY2 Methylenetetrahydrofolate reductase n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QAY2_DESAH Length = 293 Score = 281 bits (720), Expect = 2e-74, Method: Composition-based stats. Identities = 88/282 (31%), Positives = 143/282 (50%), Gaps = 6/282 (2%) Query: 15 SLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSII 74 +L + Q +VSFEFFPPR + E + + +D LS+L P ++S+T+GA + + + Sbjct: 5 NLYKNQSDPSVSFEFFPPRDDKAESSFYGVVDALSALNPAYMSMTFGAGGSTSEGSFQAV 64 Query: 75 KGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG-----KPE 129 K + L ++ P E+ + Y G+ I +RGD P G + Sbjct: 65 KRMMIEKNLPMVAYIAGYGLGPHEITEVLDRYKALGVETIFVIRGDKPRTDGFTPHPESF 124 Query: 130 MYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVE 189 +ASDL+ + + DFD+ A YPE H +A+S + D+ L+ K D GA + Q+F+D + Sbjct: 125 AHASDLIRFISDRYDFDLGCAGYPEGHVQAESLEKDVEYLRLKQDNGAQYVVAQYFYDND 184 Query: 190 SYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDA-ET 248 S+ R+ D C +GI + IIPGI+P+ K + + +P + + D L +D E Sbjct: 185 SFYRYVDLCRKSGITIPIIPGIMPIYTVKLTRMLCKLCGSTLPTGLREKLDSLTNDKSEA 244 Query: 249 RKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 +G N A D + L +GV HFYT++R+ I L Sbjct: 245 VADLGVNFAFDQCRDLVLKGVDGLHFYTMDRSGSVLKIVQRL 286 >UniRef50_B2A780 Methylenetetrahydrofolate reductase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A780_NATTJ Length = 305 Score = 280 bits (716), Expect = 5e-74, Method: Composition-based stats. Identities = 84/282 (29%), Positives = 141/282 (50%), Gaps = 13/282 (4%) Query: 19 VQGQINVSFEFFPPR-----TSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSI 73 VSFE FPP+ + E +L +ID L+ LKP F+SVTYGA D + I Sbjct: 9 QSNGPVVSFEIFPPKRKKNQSKEDFDSLLKTIDNLARLKPDFISVTYGAGGTNSDGSLEI 68 Query: 74 IKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK------ 127 + +K++ G+ + PH T I +E+ + +N G +I+ALRGDLP K Sbjct: 69 SEYVKNK-GITSLPHFTSIGYPVEEINSYLGTIYNKGFENILALRGDLPKSPSKADLVWR 127 Query: 128 PEMYASDLVTLL-KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFF 186 ++A+DL+ ++ ++ +F I AAYPE H E+ A D+ +K K G +TQ FF Sbjct: 128 DFLHATDLIKVISRDFPNFCIGGAAYPEGHQESSYAGQDIEIMKIKEKMGVKFFLTQLFF 187 Query: 187 DVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDA 246 + +++ +F + + G++ + G++P+ + K K +++ V++P + + DD Sbjct: 188 NNDNFFKFMENVRNNGVESPVSAGVMPLISPKYVDKIIELSGVKLPKELENALENYRDDE 247 Query: 247 ETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICH 288 + + + V L GV H YT+NR E I Sbjct: 248 VEFRKRSLDYCVRQVNDLFERGVDGVHLYTMNRHEAVEEILD 289 >UniRef50_D1BTF0 Methylenetetrahydrofolate reductase n=2 Tax=Actinomycetales RepID=D1BTF0_XYLCX Length = 323 Score = 278 bits (711), Expect = 2e-73, Method: Composition-based stats. Identities = 84/295 (28%), Positives = 148/295 (50%), Gaps = 25/295 (8%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + VSFE PPR + W + RL +++P FVSVTYGA G+R ++ + T Sbjct: 14 RPTVSFELMPPRRPDAAPNFWETARRLVAVQPDFVSVTYGAGGGDRATARQVVATLLAGT 73 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE-----MYASD-L 135 + HLTC+ A+ +++ + D+ G+R +ALRGD P ++++D L Sbjct: 74 PVLPIAHLTCVGASREDVSEVIDDFLEAGVRAFLALRGDPPKDQPDWRPPVDGVHSADEL 133 Query: 136 VTLLKEV-----------------ADFDISVAAYPEVHPEAKSAQA-DLLNLKRKVDAGA 177 V LL+EV I+VA +P+ +P A + +A ++ L K AGA Sbjct: 134 VRLLREVESARAAADPSSALRGAAHPLSIAVATFPDGNPAAGTTRAQEVQRLLAKQSAGA 193 Query: 178 NRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQ 237 + AITQ F++ +SY++F +AG+ + I+ G+LP + ++ ++ ++T V P + Sbjct: 194 SFAITQLFYEADSYIQFVAEARAAGVTIPILAGLLPTTEPRRLRRVEELTGVVAPPDLLD 253 Query: 238 MFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 D L DAE + G ++++ + + G H YT N+ + + +G+ Sbjct: 254 ALDAL-PDAEAQHEYGIARSVELARAVLDAGAPGLHVYTFNKHRPALDLLAGIGL 307 >UniRef50_D1PME0 Methylenetetrahydrofolate reductase n=1 Tax=Subdoligranulum variabile DSM 15176 RepID=D1PME0_9FIRM Length = 287 Score = 277 bits (709), Expect = 3e-73, Method: Composition-based stats. Identities = 74/271 (27%), Positives = 125/271 (46%), Gaps = 4/271 (1%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDR-THSIIKGIKDRTG 82 S E FPP+ + + L ++ + L+P F+SVT+GA T + I++ G Sbjct: 13 VFSIECFPPKQTTQMEKLRGTLFAMKDLQPDFISVTFGAGGSAGGVSTVEVADLIQNELG 72 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK--PEMYASDLVTLLK 140 + A HL C+ I + G+ ++ALRGD P + +A DL +K Sbjct: 73 IPALAHLICMGNDKTSAAKILDELEQVGVHDVLALRGDRTPNRPESPDFAHACDLTAFIK 132 Query: 141 EV-ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199 F + A YPE HPEA++ + D+ NL K AGA +TQ FFD + RF + Sbjct: 133 SYKPGFSVHGACYPEGHPEAENLRQDVENLCTKQAAGAEHLVTQLFFDNMHFYRFLNLAR 192 Query: 200 SAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMD 259 AGI + + G++P+ Q ++ +++ +P+ +M DD G + A+ Sbjct: 193 RAGITLPVSAGVMPIVKRSQIERTVALSSASLPSDFTRMISRWQDDPAALYEAGIDYAVR 252 Query: 260 MVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 ++ L G H Y +N A ++ + + Sbjct: 253 QLRDLIEGGADGVHLYAMNDAAVAKKVYDGI 283 >UniRef50_Q03V90 Methylenetetrahydrofolate reductase n=2 Tax=Leuconostoc mesenteroides RepID=Q03V90_LEUMM Length = 297 Score = 275 bits (705), Expect = 1e-72, Method: Composition-based stats. Identities = 78/274 (28%), Positives = 127/274 (46%), Gaps = 5/274 (1%) Query: 16 LAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRL--SSLKPKFVSVTYGANS-GERDRTHS 72 + + + +SFE FPP+T + L+ ++ + ++SVTYGA RT Sbjct: 7 IYKKKSAPVLSFEIFPPKTEDGLHALYKTLQEVNPKETGVDYISVTYGAGGGSNHKRTKE 66 Query: 73 IIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY- 131 I + I+ G+ A +LT I+ TP L+ G+ +I ALRGD P E Y Sbjct: 67 IAEYIERNCGITALHNLTGINQTPSSLKGNLEKISVAGVENIFALRGDTPTKDYVNEYYP 126 Query: 132 -ASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES 190 A DL+ +K+ FDI A YPE H + + + +K KV +G I+Q FFD Sbjct: 127 FAKDLIKEIKKDGRFDIGAAIYPEGHVDNPTTGISVTGVKEKVISGTEFLISQLFFDNGV 186 Query: 191 YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRK 250 + ++ I V + GILP+ + Q ++ M +PA +A++ +D E + Sbjct: 187 FYNMQEALKENYIKVPVSAGILPIISRAQVERITYMIGSSLPARLAKIVHKYEDQPEALQ 246 Query: 251 LVGANIAMDMVKILSREGVKDFHFYTLNRAEMSY 284 G A++ + L GV H Y +N+ + Sbjct: 247 QAGIEYALEQIHDLLDHGVDGIHLYAMNQPNVLK 280 >UniRef50_Q2S0T1 Methylenetetrahydrofolate reductase n=4 Tax=cellular organisms RepID=Q2S0T1_SALRD Length = 319 Score = 272 bits (696), Expect = 9e-72, Method: Composition-based stats. Identities = 76/307 (24%), Positives = 132/307 (42%), Gaps = 38/307 (12%) Query: 18 EVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN-------------- 63 + + + +S+E PP+ + ++ L +P F+ VT + Sbjct: 8 DRESEPLISYEIIPPKRGGSADQILGVVEELMPYEPPFIDVTSHSAEVEYKQKDDGTWTR 67 Query: 64 --SGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL 121 +R T + I+ R ++ PH+ C T +E + G+ +++A+RGD Sbjct: 68 CVKRKRPGTIGLCAAIEARFDIDTVPHILCKGFTREETEDALIELNYLGVENVLAIRGDD 127 Query: 122 P------PGSGKPEMYASDLVTLLKEVA--------------DFDISVAAYPEVHPEAKS 161 G+ YA DLV ++++ DF + V YPE H EA + Sbjct: 128 NGYEKSISGNRSRNEYAVDLVRQIQDMNEGTYLEDLMDAEPTDFCVGVGGYPETHFEAPN 187 Query: 162 AQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAK 221 D++ LK +VDAGA+ +TQ FFD E + F D+C GI+V I+PG+ + + + Sbjct: 188 LAWDIMRLKEQVDAGADYIVTQMFFDNEYFFNFVDKCREVGIEVPIVPGLKILKRKRHLR 247 Query: 222 KFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAE 281 + IP +A D D + + +G N A+ + L GV HFY ++ A+ Sbjct: 248 LLPKYFHTEIPEELAAEVDAA--DPDDVERIGVNWAIRQARELMEAGVPGIHFYIMSSAD 305 Query: 282 MSYAICH 288 + Sbjct: 306 TVKKVVE 312 >UniRef50_C3PE90 Methylenetetrahydrofolate reductase n=8 Tax=Corynebacterium RepID=C3PE90_CORA7 Length = 307 Score = 271 bits (694), Expect = 2e-71, Method: Composition-based stats. Identities = 83/286 (29%), Positives = 133/286 (46%), Gaps = 15/286 (5%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + +SFE PPR + + L++ P +++VT SG + T + I+ I T Sbjct: 24 RTALSFEVIPPRHDADAAKIDRLLATLAAYNPDYIAVTSSQRSGWLEGTAAFIEKISRDT 83 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY---ASDLVTL 138 + HL C T +EL + G+R ++ALRGDLP G G PE + A LV L Sbjct: 84 AMRPLAHLACTAGTEEELVGWIDTLVDAGVRGLLALRGDLPEG-GMPEGHLPHADSLVRL 142 Query: 139 LKEV----------ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDV 188 ++ + VA YP H E+ + D+ L K GA+ AITQ FFD Sbjct: 143 IRRWESDRVARLAAGRLAVGVACYPNGHAESATPDEDIDVLLAKQRLGADFAITQLFFDA 202 Query: 189 ESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAET 248 E Y+RF R AG+ + +IPGI+P+++ + ++ ++ + P + E Sbjct: 203 EDYVRFAQRARLAGVRIPLIPGIMPMTSRARVERMCQLSGLAGPTKVLDQLAAATS-PEE 261 Query: 249 RKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRP 294 K +G I + K + G H YT N +++ + + +GV P Sbjct: 262 EKEIGMQITASLAKSVMNAGADGLHIYTHNNPDITTDLLNRIGVTP 307 >UniRef50_D0JBB4 Methylenetetrahydrofolate reductase n=31 Tax=Bacteria RepID=D0JBB4_BLASB Length = 320 Score = 270 bits (692), Expect = 3e-71, Method: Composition-based stats. Identities = 90/309 (29%), Positives = 133/309 (43%), Gaps = 41/309 (13%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANS----------------G 65 + SFE PP + +++++D L P F+ VTY Sbjct: 12 KTLFSFEILPPLRGHDIKDIFSTLDPLMEFNPPFIDVTYHREEFIYVEKENGLLQRRKIS 71 Query: 66 ERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS 125 R T I I ++ G++A PHL C D GI +++ LRGD Sbjct: 72 RRPGTVGICAAIMNKYGVDAVPHLICGGFNKQMTENALIDLNFLGIDNVLVLRGDPLKSE 131 Query: 126 GKP------EMYASDLVTLLKEVA------------------DFDISVAAYPEVHPEAKS 161 YA +LV +K++ DF I VA YPE H EA + Sbjct: 132 KDFIAKKDGHKYAVELVEQVKDLNRGKYLDKTFVERKESPLFDFCIGVAGYPEKHLEAPN 191 Query: 162 AQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAK 221 ++DL LK+KV++GA+ +TQ FFD + Y F +C S GI V IIPGI P+S+ KQ Sbjct: 192 IESDLFFLKKKVESGADYIVTQMFFDNKKYFSFVKKCRSEGISVPIIPGIKPISSKKQLN 251 Query: 222 KFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAE 281 + IP + + + D + +G A+ K L GV+ H+YT++R E Sbjct: 252 SLPSHFYLNIPNELVKEVEKAK-DKKIISHIGIEWAIHQSKELKNFGVEVIHYYTMDRPE 310 Query: 282 MSYAICHTL 290 Y I + Sbjct: 311 NIYKIIQAI 319 >UniRef50_A9BEZ6 Methylenetetrahydrofolate reductase n=2 Tax=Thermotogaceae RepID=A9BEZ6_PETMO Length = 315 Score = 269 bits (689), Expect = 7e-71, Method: Composition-based stats. Identities = 85/306 (27%), Positives = 132/306 (43%), Gaps = 33/306 (10%) Query: 16 LAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN------------ 63 L + + +SFE PP E +++N +D L PK+++VT AN Sbjct: 6 LIKQSNKPVLSFEIIPPNVGESIDSIFNVVDNLIEFSPKYINVTKHANEIDYVEENGKIM 65 Query: 64 ---SGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD 120 +R T + IK R +E PHL C +L I D I +I +RGD Sbjct: 66 KIIQKKRPGTVGVSASIKHRYNIEVVPHLICTGFNKYQLEDILIDLNYLRIENIFVVRGD 125 Query: 121 LPP---GSGKPEMYASDLVTLLKEVA--------------DFDISVAAYPEVHPEAKSAQ 163 +AS LV + + +F + VA YPE H E+ + + Sbjct: 126 KKRYTWKETDEYEHASQLVEQIANMNRGIYTFPTKEHNSTNFCVGVAGYPEKHFESPNFE 185 Query: 164 ADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF 223 DL LK KVD GA ITQ FFD+E Y F ++ GI+V IIPGI P+ + K Sbjct: 186 KDLDYLKLKVDMGATFIITQMFFDIEYYKNFVNKVRDLGIEVPIIPGIKPLGSKKTLYNI 245 Query: 224 ADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMS 283 +V IP + + F+ + ++G A+ +++ L GV H +T+ + ++ Sbjct: 246 PKTFHVNIPKSIVEEFENAKSS-QDEYIIGVRHAIKLIEQLLELGVPGVHLFTMGKGKIV 304 Query: 284 YAICHT 289 + Sbjct: 305 KDVLSA 310 >UniRef50_D1BI58 Methylenetetrahydrofolate reductase n=2 Tax=Micrococcineae RepID=D1BI58_SANKS Length = 354 Score = 267 bits (684), Expect = 3e-70, Method: Composition-based stats. Identities = 79/295 (26%), Positives = 142/295 (48%), Gaps = 25/295 (8%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + +SFE PPR W+++D L + +P FVSVTYGA G+R ++++ I + Sbjct: 29 RPTLSFELMPPRNPAAAPKFWSTVDHLVAARPDFVSVTYGAAGGDRTTAQTVVRRILEHA 88 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY------ASDL 135 + HLTC+ A+ D + + ++ G+R +ALRGD P + + + +L Sbjct: 89 PVLPIAHLTCVGASRDNVAEVIDEFLAEGVRSFLALRGDPPRDQPDWQPHPDGVNSSDEL 148 Query: 136 VTLLKEV-----------------ADFDISVAAYPEVHPEAKSAQ-ADLLNLKRKVDAGA 177 V LL+EV I+VA + + + A + + ++ L K AGA Sbjct: 149 VALLREVEAQRCAEDPSSALRSAARPLTIAVATFLDGNAAAGTTRSQEVQRLLEKQQAGA 208 Query: 178 NRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQ 237 + AITQ F+D +SY+ F D AG+ + I+ G+LP+++ + + +T V P + + Sbjct: 209 DFAITQLFYDADSYVGFVDEARRAGVTLPILAGLLPMTDPARLARVETLTGVPAPKALVR 268 Query: 238 MFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 + L D R G ++++ + + G H YT N+ E + + + + Sbjct: 269 DLESLT-DPAARHAHGIRASVELAEAVLAAGAPGLHIYTFNKHEAALDLLEGVHL 322 >UniRef50_C7QYL7 Methylenetetrahydrofolate reductase n=2 Tax=Actinomycetales RepID=C7QYL7_JONDD Length = 339 Score = 266 bits (681), Expect = 5e-70, Method: Composition-based stats. Identities = 83/295 (28%), Positives = 137/295 (46%), Gaps = 25/295 (8%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + VSFE PPR WN+ +L P FVSVTYGA G+RD ++++ + T Sbjct: 15 RPTVSFELMPPRNPAAAPKFWNTARKLVEAHPDFVSVTYGAAGGDRDSARTVVETLVQHT 74 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE------MYASDL 135 + HLTC+ AT D + D+ G R +ALRGD P + + +L Sbjct: 75 NVLPIAHLTCVGATRDNVADTIDDFLAAGARTFLALRGDPPKDQPDWAPPTNGVVSSLEL 134 Query: 136 VTLLKE-----------------VADFDISVAAYPEVHPEAKSA-QADLLNLKRKVDAGA 177 + LL++ + I+VA +PE + +A + + + L +K AGA Sbjct: 135 IALLRDVEAQRCQADASEALRGAMKPLTIAVATFPEGNRDAGTTREQEAARLLQKQQAGA 194 Query: 178 NRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQ 237 N AITQ F+ +Y F D S G+ + I+ GILP+++ ++ ++ +T V +P +A Sbjct: 195 NFAITQLFYTASAYTEFVDVARSLGVTIPIVAGILPMTDPQRLRRLEQLTGVPVPLELAA 254 Query: 238 MFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 D + R G ++D+ + G H YT N+ E + + + + Sbjct: 255 QLDAIAS-PHVRHSHGIAASVDLANAVLDSGAPGLHIYTFNKHEPALDLLEGVHL 308 >UniRef50_A7TTE9 Methylenetetrahydrofolate reductase n=2 Tax=Saccharomycetaceae RepID=A7TTE9_VANPO Length = 612 Score = 266 bits (681), Expect = 6e-70, Method: Composition-based stats. Identities = 73/254 (28%), Positives = 107/254 (42%), Gaps = 24/254 (9%) Query: 65 GERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG 124 R + GLE HLTC + + + +G +I+ALRGD P G Sbjct: 36 TAARRPTRSCFTAQSVLGLETCMHLTCTNMSLAAIDAALEQAHASGCHNILALRGDPPRG 95 Query: 125 S---------------------GKPEMYASDLVTLLKEVAD--FDISVAAYPEVHPEAKS 161 +A+ LV ++ F I VA YPE E Sbjct: 96 QPSTASSSESGSSGGGNGSSDGDCNFKFAAQLVRYIRSKYGNHFAIGVAGYPEGDGEQAD 155 Query: 162 AQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAK 221 + L +LK KV+ GA+ ITQ F+DV+++LR+ G+ V IIPGI+P+S + Sbjct: 156 QRLLLQHLKEKVECGADFIITQMFYDVDNFLRWVHGLREVGVTVPIIPGIMPISTYAAFL 215 Query: 222 KFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREG-VKDFHFYTLNRA 280 + VR+P Q + DD E + +G + +DM + L G V H YT+N Sbjct: 216 RRCSWCGVRVPDNFLQRLAPVSDDDELVREIGTQLVVDMCRRLLESGVVSHLHLYTMNLE 275 Query: 281 EMSYAICHTLGVRP 294 I LG+ P Sbjct: 276 RPPLVILERLGLLP 289 >UniRef50_C5BVR3 Methylenetetrahydrofolate reductase n=1 Tax=Beutenbergia cavernae DSM 12333 RepID=C5BVR3_BEUC1 Length = 337 Score = 265 bits (679), Expect = 1e-69, Method: Composition-based stats. Identities = 95/299 (31%), Positives = 149/299 (49%), Gaps = 27/299 (9%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + +SFE +PPRT E+ W +++ L P + SVTYGA+ + S+++ I T Sbjct: 11 RPTISFELYPPRTPAGEERAWETVEALVGADPDYFSVTYGASGSTATASQSLVRRILTET 70 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE------MYASDL 135 + A HLTC+ + + R + + ++G+R +ALRGD P G+ A DL Sbjct: 71 DVPAVAHLTCVGLSREHARDVVGGFLDDGVRDFLALRGDPPAGNPDWRPAPGGLARACDL 130 Query: 136 VTLLKEVAD--------------FDISVAAYP--EVHPEA--KSAQADLLNLKRKVDAGA 177 V L++++ D I+VAAYP + HP A + DL L K GA Sbjct: 131 VALIRDLEDERFAGNAHADVANRLSIAVAAYPGMQEHPGAEFRVRDCDLEALVAKQRCGA 190 Query: 178 NRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQ 237 + AITQ FFDV +Y D AG+ + ++PG+LP+++ ++ ++ ++ + +PA + Sbjct: 191 DYAITQVFFDVRAYTALVDAARGAGVRIPLVPGVLPLTDPRRIRRLCELNAIPLPAELLA 250 Query: 238 MFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAIC-HTLGVRPG 295 D D E R +G + +V L G H YT NRAE S A+ H G PG Sbjct: 251 RLDAA--DDEERVAIGLTATLALVADLLAAGAPGIHLYTFNRAEASLAVLEHAFGRVPG 307 >UniRef50_B5Y6J3 Methylenetetrahydrofolate reductase n=2 Tax=Bacteria RepID=B5Y6J3_COPPD Length = 318 Score = 262 bits (669), Expect = 1e-68, Method: Composition-based stats. Identities = 85/310 (27%), Positives = 131/310 (42%), Gaps = 41/310 (13%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKP-KFVSVTYGANSGE------------ 66 QG+I +S E PP + ++ ++D L + P F++VT A Sbjct: 9 QGRI-ISIEVLPPNRGHSAEDIFKAVDELITDYPISFINVTRHAAETTYVELEDGIIVKV 67 Query: 67 ----RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP 122 R T + + R ++ PH+ C EL + D + G++++ A+RG+ Sbjct: 68 PKVKRPGTVGLTAALMKRYSVDVVPHVLCRGMNKFELEDLLIDLYLIGVQNVFAIRGEYE 127 Query: 123 PGSGK--------PEMYASDLVTLLKEVA--------------DFDISVAAYPEVHPEAK 160 G+ YA DLV + + DF I VA YPE H EA Sbjct: 128 NAEGESKQENNKDYHTYAVDLVQQIAHMNKGHYLYQKESTMSTDFCIGVAGYPEKHFEAP 187 Query: 161 SAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQA 220 + + D+ +LK KV+AGAN ITQ FD + Y F +R S GI+V IIPGI PV + K Sbjct: 188 NLEEDMKHLKEKVEAGANYIITQMVFDFDVYKDFVERARSIGINVPIIPGIKPVVSLKSI 247 Query: 221 KKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRA 280 V IP + E VG +V+ L G H +T+ ++ Sbjct: 248 YSIPRKFFVNIPHAFLEKMQEAKSSKEE-FEVGTAFMASLVEKLLSWGAPGLHLFTMGKS 306 Query: 281 EMSYAICHTL 290 + + A+ + Sbjct: 307 KSAKALLQAV 316 >UniRef50_A6L1E2 Methylenetetrahydrofolate reductase n=45 Tax=Bacteroidetes RepID=A6L1E2_BACV8 Length = 317 Score = 258 bits (661), Expect = 1e-67, Method: Composition-based stats. Identities = 71/312 (22%), Positives = 120/312 (38%), Gaps = 38/312 (12%) Query: 16 LAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYG-------------- 61 L + SFE PP + L+ ++D L PK++++T Sbjct: 6 LIKSTDNTAFSFEILPPLKGTGIEKLYKTVDTLREFDPKYINITTHRSEYVYKELGNGLY 65 Query: 62 --ANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRG 119 R T ++ ++++ + PH+ C + ++ + D GI ++ LRG Sbjct: 66 QRTRQRRRPGTVAVAAALQNKYNITTVPHILCSGFSREDTEYVLLDLQFLGITDLLVLRG 125 Query: 120 DLPPGSGKP------EMYASDLVTLLKEVAD---------------FDISVAAYPEVHPE 158 D +A +L + + F VA YPE H E Sbjct: 126 DKAKHESAFVPENNGYNHAIELEEQINDFNKGVFVDGSPIKVTGTPFSYGVACYPEKHEE 185 Query: 159 AKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFK 218 + + + D+ LK+K++AGA A+TQ F+D Y F +R GI+V IIPGI P Sbjct: 186 SPNMEQDIYWLKKKIEAGAEYAVTQMFYDNRKYFEFVERVRKEGINVPIIPGIKPFRKLS 245 Query: 219 QAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLN 278 Q + +P +A D E + +G + + L GV HFYT++ Sbjct: 246 QLNMIPKTFKIDLPQELAGEAMKCQTDEEA-ESLGIEWCIHQCRELIACGVPSIHFYTVS 304 Query: 279 RAEMSYAICHTL 290 + + Sbjct: 305 AVNSVKEVAKAI 316 >UniRef50_B2GHG1 Methylenetetrahydrofolate reductase n=1 Tax=Kocuria rhizophila DC2201 RepID=B2GHG1_KOCRD Length = 331 Score = 257 bits (658), Expect = 2e-67, Method: Composition-based stats. Identities = 86/290 (29%), Positives = 138/290 (47%), Gaps = 23/290 (7%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 VSFE FPPR + T+W SID ++ P F SVT+G + G R + ++ ++ T Sbjct: 35 VSFEVFPPRPTTDPDTVWRSIDAMAQAGPDFFSVTHGHSGG-RGVSREALRHLRRTTRTP 93 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYASDLVTL 138 H TC L ++G+R ++ALRGD P G+G+ AS+LV L Sbjct: 94 VMAHFTCGGTDRAGLERSVEHLLDDGVRDLLALRGDPPLGAGEWVTPPGGIGRASELVRL 153 Query: 139 LK-----EVAD--------FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFF 185 ++ D +SVA YP + +ADL +L K +AGA+ AITQ Sbjct: 154 IRDVERRRFGDGFRPGTRPLSVSVACYPSP-ARGRDFEADLASLWEKQEAGADYAITQVL 212 Query: 186 FDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDD 245 ++ E Y F +R S GI + ++ G++P++N K+ ++ ++T V +P + + Sbjct: 213 YEPEDYAAFLERARSEGIHIPVVAGLMPLTNPKRLQRMTEITGVPVPERLTRFLTA--GS 270 Query: 246 AETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPG 295 + + G + ++ L G FH YT NR + + I L VR Sbjct: 271 PDELRHRGTAATLTLIDDLLDLGCAGFHLYTFNRPDAALTILEHLRVRDA 320 >UniRef50_A8F6Y4 Methylenetetrahydrofolate reductase n=2 Tax=Thermotogaceae RepID=A8F6Y4_THELT Length = 315 Score = 256 bits (655), Expect = 6e-67, Method: Composition-based stats. Identities = 74/303 (24%), Positives = 128/303 (42%), Gaps = 34/303 (11%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE------------- 66 +GQI +S E PP + + ++ +D L + F++VT A Sbjct: 12 KGQI-LSIEILPPNRGQNIEEIYAVLDELMNFPISFINVTKHAPEMTYLELEDGIVKVPK 70 Query: 67 --RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG 124 R T + + +R ++ PH+ C ++ + D G+R++ +RG+ Sbjct: 71 VKRPGTVGMTAALMNRYNIDVVPHVLCFGMNKYQIEDMLIDLHLIGVRNLFVIRGEYENQ 130 Query: 125 SGKP---EMYASDLVTLLKEVA--------------DFDISVAAYPEVHPEAKSAQADLL 167 + + +ASDLV + + DF I VA YPE H EA + + D+ Sbjct: 131 TIEEKDSYSHASDLVKQISNMNMGEYLYPCENAKPTDFCIGVAGYPEKHFEAPNIEEDMR 190 Query: 168 NLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMT 227 LK+K+++GA+ ITQ FD + Y +F +R I+V IIPG+ PV + K Sbjct: 191 YLKKKIESGADYVITQMIFDFDVYKKFVERARQLSINVPIIPGVKPVVSLKSIYTIPRKF 250 Query: 228 NVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAIC 287 V IP + E +G +V+ L G H +T+ + + + A+ Sbjct: 251 FVNIPESFVKQMQEAKTHREE-FQIGTKYMAKLVEKLLSSGAPGVHVFTMGKGQSTKALL 309 Query: 288 HTL 290 + Sbjct: 310 EAV 312 >UniRef50_A8Q9P3 Methylenetetrahydrofolate reductase n=1 Tax=Malassezia globosa CBS 7966 RepID=A8Q9P3_MALGO Length = 515 Score = 255 bits (652), Expect = 1e-66, Method: Composition-based stats. Identities = 68/261 (26%), Positives = 115/261 (44%), Gaps = 48/261 (18%) Query: 48 LSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYW 107 +S L P+FV +T+ A D T ++K ++ G+E HLTC + ++ R+ Sbjct: 1 MSKLGPEFVDITWNAGGRTSDMTTQLVKTVQTYFGVETCMHLTCTNMPRSKIEVALREAK 60 Query: 108 NNGIRHIVALRGDLPPGSGKPE------MYASDLVTLLKEVAD--FDISVAAYPEVHPEA 159 G R+++ALRGD P E +A +LV ++E F I+VA +PE HPEA Sbjct: 61 EFGCRNVLALRGDPPAAGSPWEPHAAGFSHAFELVQYIREHYGDYFSIAVAGFPEGHPEA 120 Query: 160 -KSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFK 218 + ++ +LK+K+DAGA+ TQ F+D+++++ + R Sbjct: 121 VGGPELEMQHLKQKIDAGADFIFTQMFYDLDAFVNWTRRFFH------------------ 162 Query: 219 QAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSRE---GVKDFHFY 275 D + +D E ++VG + DM K + + H Y Sbjct: 163 ------------------DALDPVKEDDEQVRIVGTRLVGDMCKKILEHPDLDIHGVHIY 204 Query: 276 TLNRAEMSYAICHTLGVRPGL 296 T+N S + LG+ P + Sbjct: 205 TMNLERGSRMLLEYLGLTPSV 225 >UniRef50_A6W769 Methylenetetrahydrofolate reductase n=1 Tax=Kineococcus radiotolerans SRS30216 RepID=A6W769_KINRD Length = 298 Score = 253 bits (648), Expect = 3e-66, Method: Composition-based stats. Identities = 96/278 (34%), Positives = 139/278 (50%), Gaps = 7/278 (2%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 Q S EF P E Q W +++RL+ L+P F SVTYGA G R+ T + + RT Sbjct: 17 QRRFSVEFSPAHDEEGAQRQWRAVERLARLRPVFASVTYGAGGGTREGTVELASRLAART 76 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL-----PPGSGKPE--MYASD 134 L HLT + + +LR + RD G+ ++ALRGD P P+ +A + Sbjct: 77 DLRPVAHLTAVGQSVPQLRGVVRDLLAGGVTDVLALRGDPDGDPRAPWRAHPQGLQHADE 136 Query: 135 LVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 LV L VAA+P HPE++ DL +L K AGA AI Q FDVE +LR Sbjct: 137 LVRLALAEGVRSAGVAAFPLGHPESRDLDEDLRHLLGKFAAGAGFAIAQLTFDVEDFLRL 196 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGA 254 RDR +AG ++PG+LPV++ K + +T+ P+W+ + DD + G Sbjct: 197 RDRLAAAGCTAPLVPGLLPVTSPKVLEVTRRLTDGHEPSWLQRRLAPFLDDRGAFREEGV 256 Query: 255 NIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 +A++ + L EGV H Y+LN A + LG+ Sbjct: 257 RLALEDGRRLLAEGVPLLHLYSLNAAGNVETLVEELGL 294 >UniRef50_D0YUL0 Methylenetetrahydrofolate reductase n=1 Tax=Mobiluncus mulieris 28-1 RepID=D0YUL0_9ACTO Length = 350 Score = 246 bits (628), Expect = 8e-64, Method: Composition-based stats. Identities = 99/301 (32%), Positives = 143/301 (47%), Gaps = 18/301 (5%) Query: 4 FHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN 63 F + R A +S + VSFE +PPR + W IDRL P +VSVT+G + Sbjct: 25 FTSVSRGANPKSSRNPTRPVRVSFELYPPRNPDPFSQAWAGIDRLLDAHPDYVSVTFGTS 84 Query: 64 SGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP 123 + + S++ R G HLTC+ T EL T + + G+R +ALRGD P Sbjct: 85 NSTSASSQSVLAHALQRLGRPVLAHLTCVGKTRTELSTTITEMLDIGVRDFLALRGDNPK 144 Query: 124 GSGKPE------MYASDLVTLLKEVA--------DFDISVAAYPEVHPEAKSAQADLLNL 169 GS E AS LVTLL+EVA I+VAAYP A++ + L Sbjct: 145 GSVNWEPAPGEFSRASQLVTLLREVAAEYLGDARAISIAVAAYPAGTVSARTNA--VAAL 202 Query: 170 KRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNV 229 K AGA+ AITQ F++ + Y D G+ + IIPGI+P ++ + ++ +T V Sbjct: 203 AEKQSAGADFAITQVFYNADDYGALLDSATYQGVSIPIIPGIIPFTDAARLQRLEGLTGV 262 Query: 230 RIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHT 289 +P+ + + + D E R L G + +D V L + G HFYT NR + Sbjct: 263 SVPSRLQAISE--ISDPEERFLEGLSATLDFVNDLIQAGAPGLHFYTFNRPRPVLDLVEH 320 Query: 290 L 290 L Sbjct: 321 L 321 >UniRef50_B7AVK8 Methylenetetrahydrofolate reductase n=1 Tax=Bacteroides pectinophilus ATCC 43243 RepID=B7AVK8_9BACE Length = 218 Score = 242 bits (618), Expect = 1e-62, Method: Composition-based stats. Identities = 69/207 (33%), Positives = 110/207 (53%), Gaps = 5/207 (2%) Query: 48 LSSLKPKFVSVTYGANSG-ERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDY 106 + +P ++SVT+GA ++T + + IK++ +E HLTC+ E+ R+ Sbjct: 1 MCDCRPDYISVTFGAGGSSNNNKTIQLARKIKEKYHVEPVVHLTCLCYNRAEIDEFVREL 60 Query: 107 WNNGIRHIVALRGDLPPGSG--KPEMYASDLVTLLKEVAD--FDISVAAYPEVHPEAKSA 162 GI +I+ALRGD P + +ASDL+ L+ F I+ A YP+VHPE + Sbjct: 61 TAEGIENILALRGDRNPDVPAKEDFAHASDLIKYLRATTGDRFCIAGACYPDVHPETGNR 120 Query: 163 QADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKK 222 D+ NLK K DAGA+ I+Q FFD +++L+F C A I+V I+PGI+P N Q ++ Sbjct: 121 VDDINNLKIKTDAGADILISQLFFDNDTFLQFVSDCRRARIEVPIVPGIMPCINAAQIQR 180 Query: 223 FADMTNVRIPAWMAQMFDGLDDDAETR 249 M + P ++ D+ + Sbjct: 181 MVTMCGAKFPERFRKLIRKYGDNKDAL 207 >UniRef50_UPI00015B5A5C PREDICTED: hypothetical protein n=1 Tax=Nasonia vitripennis RepID=UPI00015B5A5C Length = 326 Score = 239 bits (610), Expect = 9e-62, Method: Composition-based stats. Identities = 76/273 (27%), Positives = 128/273 (46%), Gaps = 10/273 (3%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN-SGERDRTHSIIKGIKDR 80 + S+E FP + + Q + +P F ++T+ + +R S+ + Sbjct: 46 ESFCSYELFPTKCHGVYQGFFRDTQ---ICEPLFYALTWHEGWATGEERFPSLKSA--EV 100 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLK 140 H T + I GI +I AL+ +ASDLV ++ Sbjct: 101 FPRNTLLHCTAKGLKKTDAEMILTRALELGIANIFALQ-GDSGSDDGDFDHASDLVKFIR 159 Query: 141 EVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRC 198 E F I VA YPE+HP + S + D+ LK KVDAGA+ +TQFFF+ + +++F + C Sbjct: 160 ERYGQQFSICVAGYPEMHPHSPSKELDIFYLKAKVDAGADFILTQFFFESQLFIKFVNDC 219 Query: 199 VSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAM 258 GI V IIPGI P ++ K K ++ + IP W+ + ++DD E + G ++++ Sbjct: 220 REVGISVPIIPGIYPFTDVKLLGKMIEICHTNIPDWIQEELRHIEDDDEAVRKFGIDLSV 279 Query: 259 DMVKILSRE-GVKDFHFYTLNRAEMSYAICHTL 290 ++K + +H YTLNR+ + + L Sbjct: 280 KLIKEIRESAHFCGYHVYTLNRSFSAIEVHRQL 312 >UniRef50_C2KSD1 Methylenetetrahydrofolate reductase n=2 Tax=Mobiluncus RepID=C2KSD1_9ACTO Length = 307 Score = 236 bits (603), Expect = 6e-61, Method: Composition-based stats. Identities = 95/282 (33%), Positives = 137/282 (48%), Gaps = 18/282 (6%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 + VSFE +PPR + W IDRL P +VSVT+G ++ + S++ R G Sbjct: 1 MRVSFELYPPRNPDPFSQAWAGIDRLLDAHPDYVSVTFGTSNSTSASSQSVLAHALQRLG 60 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE------MYASDLV 136 HLTC+ T EL T + + G+R +ALRGD P GS E AS LV Sbjct: 61 RPVLAHLTCVGKTRAELSTTITEMLDIGVRDFLALRGDNPKGSVNWEPAPGEFSRASQLV 120 Query: 137 TLLKEVA--------DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDV 188 TLL+EVA I+VAAYP A++ + L K AGA+ AITQ F++ Sbjct: 121 TLLREVAAEYLGDARAISIAVAAYPAGTVSARTNA--VAALAEKQSAGADFAITQVFYNA 178 Query: 189 ESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAET 248 + Y D G+ + IIPGI+P ++ + ++ +T V +P+ + + + D E Sbjct: 179 DDYGALLDSATYQGVSIPIIPGIIPFTDAARLQRLEGLTGVSVPSRLQAISE--ISDPEE 236 Query: 249 RKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 R L G + +D V L + G HFYT NR + L Sbjct: 237 RFLEGLSATLDFVNDLIQAGAPGLHFYTFNRPRPVLDLVEHL 278 >UniRef50_A6W6I5 Methylenetetrahydrofolate reductase n=1 Tax=Kineococcus radiotolerans SRS30216 RepID=A6W6I5_KINRD Length = 317 Score = 235 bits (601), Expect = 1e-60, Method: Composition-based stats. Identities = 82/295 (27%), Positives = 136/295 (46%), Gaps = 30/295 (10%) Query: 11 ALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRT 70 L +A G+ +SFE FPPR+ + LW + L + +P FVSVT+GA R + Sbjct: 2 TLAPLVAGAAGRPVLSFELFPPRSESAREGLWRKLSDLLAARPDFVSVTFGAAGATRGPS 61 Query: 71 HSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM 130 ++ + T + A HLTC+ ++ E+ +A ++ + G+R+++ALRGD P G Sbjct: 62 RDLLAHVLRTTAVPAMAHLTCVGSSRREVVDLASEFLDAGVRNVLALRGDPPAGDAGWTP 121 Query: 131 Y------ASDLVTLLK----------------EVADFDISVAAYPEVHPEAKSAQADLLN 168 + A DLV LL+ + ++VAA+P + +L Sbjct: 122 HPDGVATARDLVELLQVADRRRAALRGARVPVDEGPLSLAVAAFPRG------GEGELAA 175 Query: 169 LKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTN 228 L+ K DAGA+ A+ Q F Y F R +AG+ + ++PG+ ++ + ++T Sbjct: 176 LRAKQDAGADFAVCQVTFSAGEYAAFVRRARAAGVRIPLLPGVAVTDCTRRLGRIGELTG 235 Query: 229 VRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMS 283 V +P + D DDA R+ + + L G H YT N AE + Sbjct: 236 VPVPVPLLAALD--TDDAPRRRRAATAFTAGLARGLLDAGAPGVHLYTFNAAEPA 288 >UniRef50_Q8KTS2 Methylenetetrahydrofolate reductase n=1 Tax=Candidatus Tremblaya princeps RepID=Q8KTS2_TREPR Length = 300 Score = 233 bits (594), Expect = 7e-60, Method: Composition-based stats. Identities = 90/274 (32%), Positives = 136/274 (49%), Gaps = 15/274 (5%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 +SFEFF PR+ L + LS P+FVSVT + G++ +I + Sbjct: 24 PGLSFEFFAPRSHAGSIRLMCAQQVLSRFVPRFVSVTRSTSLGQQAHIDTIASTL--SVF 81 Query: 83 LEAAPH-LTCIDATPDELRTIARDYWNNGIRHIVALRGD---LPPGSGKPEMYASDLVTL 138 APH L C P L R Y GIRH+V LRGD P G PE LV++ Sbjct: 82 PRTAPHVLFCQC--PRALARELRAYELLGIRHLVLLRGDNGIAPGSIGAPE-----LVSM 134 Query: 139 LKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRD 196 ++ F I VAAYP+ HP + + D+ L RKV GAN AITQ F++ ++Y R +D Sbjct: 135 VRRSYGEAFYIDVAAYPDGHPMSSTIFEDVRALARKVRCGANSAITQCFYNPDAYYRLQD 194 Query: 197 RCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANI 256 G+ + + PGI+PV + +F + V +PAW+ + + L + + G ++ Sbjct: 195 ELQRLGVSLPVTPGIMPVLSHDYMSRFILPSGVDVPAWILKRLEALRYCSASVLEFGTDV 254 Query: 257 AMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 A+ + + L+ G DFH YT+N + +C + Sbjct: 255 ALSLCESLAARGASDFHLYTMNDHRAVWRVCEHV 288 >UniRef50_C7M2P8 Methylenetetrahydrofolate reductase n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7M2P8_ACIFD Length = 284 Score = 228 bits (581), Expect = 2e-58, Method: Composition-based stats. Identities = 82/275 (29%), Positives = 132/275 (48%), Gaps = 12/275 (4%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 G+ S E +P RTS+ E L ++D L SL P FVSVTYGA R + ++I+ + Sbjct: 9 GERVCSVELWPARTSDQEHRLTATLDVLRSLPPAFVSVTYGAFGSSRHESLALIERVLAD 68 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM-----YASDL 135 G HL +P++L + G ++ALRGD P +A +L Sbjct: 69 -GHRVLAHLAVAGHSPEQLVALLTHVERLGADGVLALRGDPPLDDPDDRARFVGRHALEL 127 Query: 136 VTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFR 195 V L ++ + VA +P HPEA+S + DL + K+ A A+ ITQF+F+ + R R Sbjct: 128 VELARQHTQLSVGVALHPSGHPEARSLEDDLDHQAAKL-ARADFGITQFYFEAAALTRLR 186 Query: 196 DRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGAN 255 G+ +IPG+L + +Q + +M VR+P + + +G D A R +VG Sbjct: 187 GALRGRGVTRPVIPGLLVPRSPRQLLRMGEMAAVRVPRELVEALEGPDGPARARTVVG-- 244 Query: 256 IAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 ++ EG H +++N+ E + + L Sbjct: 245 ---ELASAALEEGSPGVHLFSMNQPETTAWLLERL 276 >UniRef50_C0W5C3 Methylenetetrahydrofolate reductase n=1 Tax=Actinomyces urogenitalis DSM 15434 RepID=C0W5C3_9ACTO Length = 384 Score = 220 bits (562), Expect = 4e-56, Method: Composition-based stats. Identities = 74/299 (24%), Positives = 125/299 (41%), Gaps = 38/299 (12%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY-------------GANSGERD 68 + ++S E FPPR W ++DRL + +P FVSVTY A S R Sbjct: 44 RPSLSLELFPPRPGRYASQTWGALDRLLAARPDFVSVTYRPRFITTAGGPTAAAGSPTRL 103 Query: 69 R-------THSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL 121 + ++ + + + HLTC+ + I R + + G+R +ALRGD Sbjct: 104 HVVREHNPSEDVVAHVIATSRVPLMAHLTCLGYRKANVVEIVRLFLDMGVRRFLALRGDP 163 Query: 122 PPGSGKPEM-----YASDLVTLLKEVADFDISVAAYPEVHPEAK--------SAQADLLN 168 P G ++ +A LV +++EV A H + ++ Sbjct: 164 PRGVAAEDVVGELRHADQLVRVIREVEAEYFDDGA---RHVQVAVAAYPAAVDYAREIGV 220 Query: 169 LKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTN 228 L K AGA+ AITQ F++ E YL G+ + I+PGI+P+++ ++ + D+T Sbjct: 221 LAAKQAAGADLAITQVFYESEDYLALARAASYCGVTMPILPGIIPLTDLRRLTRLEDLTG 280 Query: 229 VRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAIC 287 V +P ++Q + G + + + L G H YT NR + + Sbjct: 281 VSVPTRLSQTLTSRQG--ASVMTAGIDATLQLAGDLIEGGAPGLHLYTFNRTRPALDVI 337 >UniRef50_Q67LF9 Methylenetetrahydrofolate reductase n=1 Tax=Symbiobacterium thermophilum RepID=Q67LF9_SYMTH Length = 326 Score = 218 bits (556), Expect = 2e-55, Method: Composition-based stats. Identities = 71/312 (22%), Positives = 132/312 (42%), Gaps = 39/312 (12%) Query: 10 DALNQSLAEVQ-GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERD 68 A+ + + +Q G V+ E PPR + + TL + R + V+V + R Sbjct: 25 SAMARLMHRLQQGAFCVTVEIDPPRGAGVAGTL-ERVRRFGD-RVDAVNVADCPMANVRM 82 Query: 69 RTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP 128 ++ ++ +EA HLT D L+ G+R+I+ALRGD P P Sbjct: 83 SPITLAHLLQRDGQVEAIFHLTTRDRNIIGLQAELLGAAGLGVRNILALRGDDPSRGDHP 142 Query: 129 E---MYASDLVTLLK-----------------EVADFDISVAAYPEVHPEAKSAQADLLN 168 + ++ D + L++ + DF I A P A +A++ Sbjct: 143 DARGVFEVDTIGLIRLAAALNRGQTVSGTPLEQGTDFAIGCACNPA----AADLEAEVSR 198 Query: 169 LKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD-MT 227 L+ KV+AGA+ A TQ +D RF+ + + + I+ G+LP+ +++ A + + Sbjct: 199 LEEKVEAGAHFAQTQPVYDPRQVERFQAKLAGR-VKIPILYGVLPLKSYEFADRLNRTVP 257 Query: 228 NVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAIC 287 + IP W+ G D++ G + ++++ + V H + +N A A+ Sbjct: 258 GIVIPGWVLDRMRGRDEEE------GLRLTAELLREIGPH-VHGVHIFPMNSARRVVAVL 310 Query: 288 ---HTLGVRPGL 296 LG+R + Sbjct: 311 DLIDELGLRHSV 322 >UniRef50_D0P2W8 Methylenetetrahydrofolate reductase n=1 Tax=Phytophthora infestans T30-4 RepID=D0P2W8_PHYIN Length = 244 Score = 215 bits (548), Expect = 2e-54, Method: Composition-based stats. Identities = 73/272 (26%), Positives = 115/272 (42%), Gaps = 52/272 (19%) Query: 1 MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLS-SLKPKFVSVT 59 M S R A + + VSFEFFP +T+ L ++ + +L+P FV++T Sbjct: 1 MGKIIESIRSAYATRTDDTSARPTVSFEFFPAKTNAGVFNLLTRVEEMGLALQPTFVTLT 60 Query: 60 YGANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRG 119 + + + I I++ L+ HLTC ++L+ I ++ GIR+I+ALRG Sbjct: 61 WRSAFKDEALWLRIGAHIQNEFQLDVLLHLTC-HLPTEQLKRILKNARAAGIRNILALRG 119 Query: 120 DLPPGSGKPE------MYASDLVTLLKEVAD--FDISVAAYPEVH----------PEAKS 161 D P G+ + A DL+ L++E F I+ A Y EVH P ++ Sbjct: 120 DPPIGAEQWSPVEGGLSNAVDLIKLIREEHGDYFCIACAGYAEVHTESWNHPDLPPSNEA 179 Query: 162 AQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAK 221 DL LK K DAGA+ ITQFFFDV++ + + Sbjct: 180 RALDLQRLKAKQDAGADFIITQFFFDVDNMIHW--------------------------- 212 Query: 222 KFADMTNVRIPAWMAQMFDGLDDDAETRKLVG 253 R+P + D + +D + G Sbjct: 213 -----CKTRVPEKVLAALDAIKNDDAAVRRYG 239 >UniRef50_A7S5W8 Methylenetetrahydrofolate reductase n=1 Tax=Nematostella vectensis RepID=A7S5W8_NEMVE Length = 619 Score = 210 bits (534), Expect = 6e-53, Method: Composition-based stats. Identities = 80/290 (27%), Positives = 125/290 (43%), Gaps = 20/290 (6%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSL---KPKFVSVTYGANS------GERDRTHS 72 + S E FPP+T +L+ + RL+ L KP F +T+ + T Sbjct: 28 ERFFSVEIFPPKTFNGATSLFGIMCRLNELEDTKPLFADITWKPSKEPMSDKCLEPTTLL 87 Query: 73 IIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALR---GDLPPGSGKPE 129 I + H+ T ++ G+ I A R G + Sbjct: 88 IAASARQVNNFNTIIHIPYFGTTRTQVFEHLMRAKEFGVCGIRAQRPAPGITYENPVHED 147 Query: 130 MYAS--DLVTLLKEV--ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFF 185 ++S DL+ +K+ DF I+V YP +DL LKR+VDAGA+ TQ F Sbjct: 148 GFSSIEDLIIFIKQEFGNDFAIAVTGYPS--QRCDWYDSDLALLKREVDAGADFITTQLF 205 Query: 186 FDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMT-NVRIPAWMAQMFDGLDD 244 F+VE++ +F C + GID+ IIPGILP+ N + + M V++P + ++ + Sbjct: 206 FEVETFFKFERDCRNIGIDIPIIPGILPIQNLQTVRNLRKMNFAVKVPNEILEVLKSGKE 265 Query: 245 DAETRKLVGANIAMDMVKILSREG-VKDFHFYTLNRAEMSYAICHTLGVR 293 D E + G A M + L G V+ H YTLN + +I L + Sbjct: 266 DLEAIQAFGIQHATKMCQELFASGKVQGIHLYTLNIEKPVMSILENLKIS 315 >UniRef50_A9B657 Methylenetetrahydrofolate reductase n=1 Tax=Herpetosiphon aurantiacus ATCC 23779 RepID=A9B657_HERA2 Length = 617 Score = 207 bits (527), Expect = 5e-52, Method: Composition-based stats. Identities = 62/303 (20%), Positives = 127/303 (41%), Gaps = 27/303 (8%) Query: 6 ASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG 65 +++ L + LA+ G S E PP+ + L + ++ + F++V + Sbjct: 319 SAETTQLGRMLAD--GAFVTSVEIDPPKGHNPRRCLEGA-RQMQAAGVNFINVADSPMAR 375 Query: 66 ERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS 125 R + I+ + G+E H T D + L++ G+R+I+AL+GD P Sbjct: 376 VRMSALPMCNLIQQQVGMETILHFTTRDRSLMGLQSDLLGAHALGVRNILALKGDPPSFG 435 Query: 126 GKP---EMYASDLVTLLKEVADFDISV--AAYPEVHP-----------EAKSAQADLLNL 169 P ++ D + L+K +A + V A P A+ ++ L Sbjct: 436 AYPGTSGVFDVDTIGLVKVIAGMNSGVDTAGNDIGTPTNFLIGVALNINAEDPDWEIDRL 495 Query: 170 KRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTN 228 +KV AGA+ A+TQ +D RF D+ + + II G++PV +++ A ++ Sbjct: 496 HQKVAAGAHYAMTQISYDATELDRFLDKL--GPLPIPIILGLMPVQSYRHASFLHNEVPG 553 Query: 229 VRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMSYAIC 287 + +P + + + + VG ++ +++ ++ + + R EM+ + Sbjct: 554 ITLPKDVLERMKEAGANG---RAVGVQVSQEILAAAYDR-IQGVYIMPSFGRYEMAAEVL 609 Query: 288 HTL 290 L Sbjct: 610 EVL 612 >UniRef50_D1CBD0 Methylenetetrahydrofolate reductase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CBD0_THET1 Length = 629 Score = 204 bits (520), Expect = 3e-51, Method: Composition-based stats. Identities = 66/293 (22%), Positives = 128/293 (43%), Gaps = 33/293 (11%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 +G+ VS E PP+ +TL + L+ K++++ + R ++ K I++ Sbjct: 329 RGEFIVSVEVDPPKGLSARKTLEGA-KMLAEKGVKWINIGDSPMARVRMSCIALAKLIQE 387 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASDLV 136 T +EA H T D +++ GIR+++AL GD P P+ ++ D V Sbjct: 388 TTPIEAIIHFTTRDRNVMAIQSDLIGAHAMGIRNVIALTGDPPSLGDYPDATGVWDIDSV 447 Query: 137 TLLKEV-----------------ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANR 179 L+K + A F I+ A V P AK + + + +K++AGA+ Sbjct: 448 GLIKALSRMNEGFDLAGKQIGAKAGFCIAAA----VDPTAKDIEFQIDRMWQKIEAGAHL 503 Query: 180 AITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQM 238 ++Q +DVE +F DR + I V I G+LP+ ++K A+ ++ + +P + Sbjct: 504 IMSQPLYDVEDLQKFLDRVGN--IPVPFILGVLPLQSYKHAEFMHNEVPGIYVPEHILDA 561 Query: 239 FDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMSYAICHTL 290 + G +A ++V ++ V+ + + R ++ + L Sbjct: 562 MRRAGSNG---LQEGVRLAQELVHQ-AQHLVQGIYLMPSFGRYDVCAQVFEAL 610 >UniRef50_Q2LQ11 Methylenetetrahydrofolate reductase n=1 Tax=Syntrophus aciditrophicus SB RepID=Q2LQ11_SYNAS Length = 618 Score = 204 bits (519), Expect = 3e-51, Method: Composition-based stats. Identities = 57/289 (19%), Positives = 112/289 (38%), Gaps = 21/289 (7%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 GQ S E PPR + + + R +++ G + R I Sbjct: 327 CSGQKVTSVEILPPRAGD-FSNMLAKVRRCHEAGVDAINIPDGPRASARVSPMITALVIL 385 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASDL 135 G+E H C D +++ + G+ + + + GD P PE ++ D Sbjct: 386 REVGIEPVVHYCCRDRNLIGMQSDLLGGYAVGLVNYLIITGDPPKLGNCPEATGVFDVDS 445 Query: 136 VTLLKEVADFDIS--VAAYP-----------EVHPEAKSAQADLLNLKRKVDAGANRAIT 182 + L V + + + P +P A + ++ +K++AGA AIT Sbjct: 446 IGLTSVVHNLNSGWDIGGSPVDPPTGIFIGVGANPCAVDLEREIDRYFQKIEAGAEFAIT 505 Query: 183 QFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD-MTNVRIPAWMAQMFDG 241 Q FD ++ RF DR V ++ G+ P+ +++ A+ + + V +P + + Sbjct: 506 QPVFDEKALFRFLDRVEKHSKRVPVLAGVWPLLSYRNAEFMNNEVPGVMVPREILERMAR 565 Query: 242 LDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHT 289 + E+++ G IA + + + V F LN E++ ++ Sbjct: 566 CETREESQR-TGIEIARAICEKIHER-VAGFQVCAPLNNVEIALSVLRK 612 >UniRef50_Q2RJ84 Methylenetetrahydrofolate reductase n=2 Tax=Bacteria RepID=Q2RJ84_MOOTA Length = 306 Score = 202 bits (514), Expect = 1e-50, Method: Composition-based stats. Identities = 69/303 (22%), Positives = 127/303 (41%), Gaps = 41/303 (13%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVS-VTYGANSGERDRTHSIIKGIK 78 QGQ VS E PP+ ++ + I + ++L +V + N R SI G+ Sbjct: 12 QGQFLVSGEIGPPKHADPTE-----IKKHAALLKDYVDAMNLTDNQTAIVRLSSIAAGVH 66 Query: 79 D-RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL------PPGSGKPEMY 131 + G E +T D L++ ++ G+R+++ L GD P ++ Sbjct: 67 VLQAGGEPIIQMTVRDRNRIALQSDLLGAYSLGMRNVLCLSGDHQSFGNHPTAKNVHDVD 126 Query: 132 ASDLVTLLKEVAD----------------FDISVAAYPEVHPEAKSAQADLLNLKRKVDA 175 + L+ ++K++ D F I AA +P A + ++ L++K++A Sbjct: 127 SLQLIRIVKDLRDEKKFACGEEIKGQEPRFFIGAAA----NPFADPFEFRVMRLEKKINA 182 Query: 176 GANRAITQFFFDVESYLRFRDRCVSAGI--DVEIIPGILPVSNFKQAKKFAD-MTNVRIP 232 GA+ TQ FD+E + RF G+ +II G++P+ + + AK + + +P Sbjct: 183 GADFIQTQCIFDMERFERFMALVRERGLHKRAKIIAGVMPLKSARAAKYMQQSVAGMIVP 242 Query: 233 AWMAQMFDGLDDDAETRKLVGANIAMDMVKILSR-EGVKDFHFYTLNRAEMSYAICHTLG 291 + + D K G I ++ +K L EGV H + ++ I G Sbjct: 243 DEIVNRMEKASDP----KAEGVAICVEQIKHLQSIEGVAGVHIMAVMWEDIIPTIVKEAG 298 Query: 292 VRP 294 + P Sbjct: 299 LYP 301 >UniRef50_B0VZI6 Methylenetetrahydrofolate reductase n=2 Tax=Culicini RepID=B0VZI6_CULQU Length = 443 Score = 201 bits (512), Expect = 2e-50, Method: Composition-based stats. Identities = 70/282 (24%), Positives = 123/282 (43%), Gaps = 24/282 (8%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGER----DRTHSII 74 ++ S E P + + RL+ P F S+ + +++ + T + Sbjct: 172 TSERLCYSIELIP------REDFHLDLGRLA---PVFCSLPWISDNNLQYQRFADTPMLK 222 Query: 75 KGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASD 134 K A PHL+C + T ++ + + G ++ +RGD G+ ++ D Sbjct: 223 MTAKIVPHCSAVPHLSCYNITETQVD----KFVDMGNWNLFVIRGDTVS-EGQRFQHSCD 277 Query: 135 LVTLLK--EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYL 192 LV L+ D I V YP HPE+ S D+ LK+KVD G + +TQ +D S+L Sbjct: 278 LVEYLRAKNNPDLTIGVGGYPYGHPESPSVDYDVKYLKQKVDLGVDFIVTQTLYDAASFL 337 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDD-AETRKL 251 + D C AGI V I+PG+ + Q + +T V PA + ++ D + + Sbjct: 338 AYVDECRRAGITVPIVPGLFLPGSPDQLETVLALTRVNPPAGVRELLQSHAHDEPDQFEA 397 Query: 252 VGANIAMDMVKILSRE---GVKDFHFYTLNRAEMSYAICHTL 290 ++++ L RE V+ HF+T NR ++ + + Sbjct: 398 FVVKHFAELIRTLRRERPDEVRLVHFFTFNRLDLLKKVLDAI 439 >UniRef50_B9L045 Methylenetetrahydrofolate reductase n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=B9L045_THERP Length = 624 Score = 201 bits (512), Expect = 2e-50, Method: Composition-based stats. Identities = 58/293 (19%), Positives = 114/293 (38%), Gaps = 33/293 (11%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + VS E PP+ + + + L + +F++V + R ++ ++ T Sbjct: 332 EFVVSVEIDPPKGLNPSKAIEGA-RLLRQVGVEFINVADSPMARVRMSALALCVILQQET 390 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASDLVTL 138 G+E HLT D L+ G+R+I+AL GD P P +Y D + L Sbjct: 391 GVETILHLTTRDRNLMGLQADLLGAHALGVRNILALTGDPPTLGDYPHATPVYDLDSIGL 450 Query: 139 LKEVAD-----------------FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAI 181 ++ + + F I VA P Q ++ L K+ AGA+ + Sbjct: 451 VRLLQNFRQGFDAGGASIGRPAMFTIGVAC----DPTRPDLQQEIERLHAKLAAGADFVM 506 Query: 182 TQFFFDVESYLRFRDR--CVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQM 238 TQ FD ++ F + I+V ++ G+LP+ +F+ A ++ + + + Sbjct: 507 TQPVFDFSTWRNFVAQYEIRYGPIEVPVLLGVLPLQSFRHASFLHNEVPGITLTEEALER 566 Query: 239 FDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMSYAICHTL 290 + + G +A +++ V+ + + R E+ + L Sbjct: 567 MRRAGPNG---RAEGVAMARELIAEACEF-VQGIYLMPSFGRYEVVAEVLSAL 615 >UniRef50_B5YJV3 Methylenetetrahydrofolate reductase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=B5YJV3_THEYD Length = 295 Score = 201 bits (512), Expect = 2e-50, Method: Composition-based stats. Identities = 61/300 (20%), Positives = 112/300 (37%), Gaps = 27/300 (9%) Query: 13 NQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHS 72 N + G ++ E PP+ + + + +L LK +V + N R R S Sbjct: 3 NLRKRLMSGDFVITVEITPPKGPD----ITGMVKKLEELKTMVDAVNFTDNPSARMRLCS 58 Query: 73 IIK-GIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE-- 129 + + G E + C D +++ GIR+++ + GD P E Sbjct: 59 LAACKLSMDIGFEPVLQMACRDRNRLAIQSDLLGAHALGIRNLLVMTGDHPVWGDHREAK 118 Query: 130 -MYASDLVTLLKEVADFDISVAAYPE-------------VHPEAKSAQADLLNLKRKVDA 175 +Y D L+K V + + + V+P A+ L ++K+ Sbjct: 119 PVYDIDSSILVKLVGNLNSGLDINGNKLNGKTEFFCGAVVNPNAEPLMPQLKRFEQKLKM 178 Query: 176 GANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNVRIPAW 234 GA TQ F++E RF D S + ++I GI+ + K A + V +P+W Sbjct: 179 GAEFFQTQMIFEIEKLERFID--YSKKFNTKVIAGIVLIRTKKMLHYLASKVPGVVMPSW 236 Query: 235 MAQMFDGLDDDAETRKLVGANIAMDMVKILSRE-GVKDFHFYTLNRAEMSYAICHTLGVR 293 + + L + E + G + A ++ L H ++ E + L +R Sbjct: 237 LIDKIERL--NDEDVEKFGVDFAGSIILNLMERKLCDGVHIMAFSKVEEVKNLLDFLKIR 294 >UniRef50_Q3M8T4 Methylenetetrahydrofolate reductase n=56 Tax=Cyanobacteria RepID=Q3M8T4_ANAVT Length = 357 Score = 201 bits (512), Expect = 2e-50, Method: Composition-based stats. Identities = 68/304 (22%), Positives = 115/304 (37%), Gaps = 28/304 (9%) Query: 10 DALNQ-SLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERD 68 ALN S A G+ V+ E PP+ + + + V++T G+ + R Sbjct: 56 TALNYFSKAAQAGEFLVTAEVAPPKGGNPTHMME--MAATLKGRVHAVNITDGSRAVLRM 113 Query: 69 RTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP 128 + + I + G+E + C D L+ GIR+I+AL GD P Sbjct: 114 SSL-VASAILLQQGIEPVCQMACRDRNRIALQADLMGAHALGIRNILALTGDPVKAGDHP 172 Query: 129 E---MYASDLVTLLKEVADFDISVAAY--------------PEVHPEAKSAQADLLNLKR 171 E ++ + V LL+ + + V V P+ S +R Sbjct: 173 EAKAVFDLEAVRLLQLIRKMNQGVDCNDKPLTDGATDLFVGAAVDPQCASWSGLQSRFER 232 Query: 172 KVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD-MTNVR 230 K++AGA +Q D E +F D+ S ++ GI + + K A+ + V Sbjct: 233 KIEAGAQFFQSQLITDFERLEKFMDKIASVHKK-PVLAGIFLLKSAKNAQFINRCVPGVN 291 Query: 231 IPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 IP + + D E G IA + V+ ++R+ H + R ++ I Sbjct: 292 IPEHIIERLAKAKDPLEE----GVKIAAEQVQ-IARQLCHGVHMMAVKREDLIPQILDLA 346 Query: 291 GVRP 294 GV P Sbjct: 347 GVSP 350 >UniRef50_B4LC84 Methylenetetrahydrofolate reductase n=3 Tax=Drosophila RepID=B4LC84_DROVI Length = 390 Score = 201 bits (512), Expect = 3e-50, Method: Composition-based stats. Identities = 58/248 (23%), Positives = 104/248 (41%), Gaps = 17/248 (6%) Query: 53 PKFVSVTY-----GANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYW 107 P F+S+ + ER T +I+ + T + A PHL+ T + + Sbjct: 132 PTFISIVWLPQYWNVMPIERVETLQLIRNL--ETHIPAMPHLSLFRQTKERIDEFL---- 185 Query: 108 NNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVA--DFDISVAAYPEVHPEAK-SAQA 164 R+++A+RGD + Y+ LV + V + I+VA +P+ + Sbjct: 186 ALNFRNMLAVRGDKTH-EDQVYRYSHQLVEHARRVRGVNISIAVAGHPQGYAGGPQGLAE 244 Query: 165 DLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA 224 + LK+K+D GA+ ITQ + E+ + F +AGI I+ G++ +FK Sbjct: 245 SIEMLKKKIDNGADFIITQLCYSPETIVEFLRGARNAGIQTPIMVGVVVPDSFKSYALIE 304 Query: 225 DMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSRE--GVKDFHFYTLNRAEM 282 ++ + +PA + +D K +A+ ++ + GV FYTLNR Sbjct: 305 MISKISLPAEARAEVEKYQNDDAKVKSYFVQLALRTIQQVLDANLGVHGIQFYTLNRFGS 364 Query: 283 SYAICHTL 290 + L Sbjct: 365 VQDVLCEL 372 >UniRef50_B0K6M8 Methylenetetrahydrofolate reductase n=14 Tax=Clostridia RepID=B0K6M8_THEPX Length = 303 Score = 201 bits (511), Expect = 3e-50, Method: Composition-based stats. Identities = 64/293 (21%), Positives = 122/293 (41%), Gaps = 39/293 (13%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 + + V+ E P+ ++ +T+ + +L + +++T + R ++ ++D Sbjct: 13 KRKFVVTAEISTPKGVDITKTIEEA-RKLKGI-VDALNITDCPMANMRMSPIAVAHLLQD 70 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASDLV 136 +EA HLTC D L++ + G+R+I+AL GD P P+ +Y D + Sbjct: 71 HLNIEAIFHLTCRDRNLIGLQSELLGAYALGVRNILALTGDDPSRGDTPQAKGVYDVDSI 130 Query: 137 TLLKEV-----------------ADFDISVAAYPEVHPEAKSAQAD-LLNLKRKVDAGAN 178 LLK + +F A P + + L LK K++AGA Sbjct: 131 GLLKIISAFNRGYDYNGNKLDSPTEFCAGTTANPN------DLRDEALEKLKVKIEAGAE 184 Query: 179 RAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQ 237 TQ +D E +F ++ + +V ++ GILP+ ++K A + + IP + + Sbjct: 185 FIQTQPVYDEEILFKFIEKIKN--FNVPLLIGILPLKSYKMAVNLNEKVPGIDIPEKVLE 242 Query: 238 MFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + + G NIA++ +K + E V H L + I + Sbjct: 243 RL------KDGGREEGINIAVEFIKRIRSE-VAGIHIMPLGSTNVVLEIISRV 288 >UniRef50_Q01QP4 Methylenetetrahydrofolate reductase n=2 Tax=Acidobacteria RepID=Q01QP4_SOLUE Length = 622 Score = 200 bits (509), Expect = 5e-50, Method: Composition-based stats. Identities = 58/301 (19%), Positives = 125/301 (41%), Gaps = 24/301 (7%) Query: 7 SQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE 66 +++ + LA G+ E PPR + + + + + ++V G + Sbjct: 326 AEKSQVGAKLA--AGKFVTFVEILPPRGVDATREIAGA-KLCAEHGIDAINVPDGPRASA 382 Query: 67 RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG 126 R + I+ + G+EA H C D +++ G+R+++ + GD P Sbjct: 383 RMSAQVTCQLIQAQAGIEAVNHFCCRDRNILGIQSELLGTHGAGVRNLICITGDPPRMGA 442 Query: 127 KPE---MYASDLVTLLKEVADFD--ISVAAYPEV-----------HPEAKSAQADLLNLK 170 P+ ++ D + L+ V + + + + P +P A + ++ + Sbjct: 443 YPDATAVFDVDAIGLVNIVRNLNHGLDIGGNPMGSQTALLIGVGANPGALNMDEEIRRFE 502 Query: 171 RKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVR 230 KV+AGA +TQ FD++ F R + + ++ GI P+++++ A+ + V Sbjct: 503 WKVEAGAEYVVTQPVFDLDLLEAFLKRIEH--VKIPVLCGIWPLTSYRNAEFMVNELRVP 560 Query: 231 IPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHT 289 +P + + D+AE + G IA +MV +S+ V+ R +M+ + Sbjct: 561 VPEMFMERMRRV-DNAEKAREEGVAIAREMVARVSKM-VQGAQLSAPFGRYQMAIDVADA 618 Query: 290 L 290 + Sbjct: 619 I 619 >UniRef50_C1F3L2 Methylenetetrahydrofolate reductase n=2 Tax=Bacteria RepID=C1F3L2_ACIC5 Length = 636 Score = 197 bits (502), Expect = 3e-49, Method: Composition-based stats. Identities = 68/309 (22%), Positives = 120/309 (38%), Gaps = 34/309 (11%) Query: 8 QRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGER 67 QR L Q + + E PPR + ++ + + L+ L ++V + R Sbjct: 324 QRSRLGQMIHDRT--FVTMVEIVPPRGIDCQKEIDGA-TMLAGLGVHVINVPDSPRASAR 380 Query: 68 DRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK 127 S+ ++ ++G+E H TC D +++ + G+R+I+ L GD P Sbjct: 381 MSAQSLCIQLQQKSGIETLLHYTCRDRNVLSIQSDLLGASSIGLRNILCLTGDPPKLGNY 440 Query: 128 PEMYAS------DLVTLLKEVA--------------DFDISVAAYPEVHPEAKSAQADLL 167 P+ A LV +++ + F I AA P V ++ Sbjct: 441 PDATAVFDVDAIGLVNIVRRLNHGLDIGGNPIGASTGFTIGCAANPGV----PDIDNEVR 496 Query: 168 NLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMT 227 KV+AGA AITQ FD+ F R G + +I GI P+++ + A+ + Sbjct: 497 RFAYKVEAGAEYAITQPVFDLRILESFLKRIE--GFRIPVIAGIWPLTSLRNAEFMRNDL 554 Query: 228 NVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAI 286 V +P + E + G IA +M++ +R V+ R + + Sbjct: 555 RVSVPDSILLRMQQAAT-PELARAEGIRIAQEMLET-ARPMVEGVQVSAPFGRYTAAAEV 612 Query: 287 CHTLGVRPG 295 G+ PG Sbjct: 613 L--AGILPG 619 >UniRef50_A4XIN5 Methylenetetrahydrofolate reductase n=1 Tax=Caldicellulosiruptor saccharolyticus DSM 8903 RepID=A4XIN5_CALS8 Length = 604 Score = 196 bits (500), Expect = 6e-49, Method: Composition-based stats. Identities = 62/308 (20%), Positives = 125/308 (40%), Gaps = 38/308 (12%) Query: 8 QRDALNQSLAEVQGQ----INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN 63 Q+ L + +E+ + + E PP+ E+E+T + L V++ Sbjct: 306 QKSILKDTPSELSQKLGKKFVFTVEISPPKGIELEKT-KEGVKLLKEAGADTVNIADSPM 364 Query: 64 SGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP 123 + R ++ +K+ G+E+ H TC D L++ G+++++AL GD P Sbjct: 365 ARVRISPIALAHILKEELGVESILHFTCRDRNLISLQSELLGAAALGVKNVLALTGDPPS 424 Query: 124 GSGKP------EMYASDLVTL--------------LKEVADFDISVAAYPEVHPEAKSAQ 163 P ++ + LV + + + +F I VA ++ A Sbjct: 425 IGDYPQAKPVFDVNSEGLVLILNKLNSGTDYMGNPIGKATNFTIGVA----LNLNADDLD 480 Query: 164 ADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF 223 ++ LKRK++ GA+ TQ ++VE+ +F ++ I+ GILP+ + + A+ Sbjct: 481 KEIERLKRKIENGAHFIETQPIYEVEALEKFFEKVDFKLP--PILGGILPLRSSRHAEFL 538 Query: 224 -ADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAE 281 ++ + IP + + D + G IA ++V + V + + E Sbjct: 539 HNEVPGITIPDKIRERMKNSKDPVKE----GIEIACEIVDRIKEM-VSGIYIMPPFEKYE 593 Query: 282 MSYAICHT 289 M+ I Sbjct: 594 MAAEIIKR 601 >UniRef50_Q2LZ54 Methylenetetrahydrofolate reductase n=1 Tax=Drosophila pseudoobscura pseudoobscura RepID=Q2LZ54_DROPS Length = 433 Score = 195 bits (497), Expect = 1e-48, Method: Composition-based stats. Identities = 53/249 (21%), Positives = 100/249 (40%), Gaps = 16/249 (6%) Query: 53 PKFVSVTYGANSGERDRTHSIIKGIKD----RTGLEAAPHLTCIDATPDELRTIARDYWN 108 P F+S+ + + ++ ++ + PHL+ T + L Sbjct: 178 PTFLSIVWLGATYCSVDPIELVTSLQLARSLEARIPVMPHLSLYCLTEERLNEFL----A 233 Query: 109 NGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVAD--FDISVAAYPEVH---PEAKSAQ 163 +++ +RGD G+ Y +V ++ I VA YPE + E + Sbjct: 234 LNFTNVLPIRGDAVK-EGQTFRYTQQVVEHIRRQRGDRISICVAGYPEGYTNLAEPQDPA 292 Query: 164 ADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF 223 + LK K+ AGA+ ITQ + ++ ++F SAGI V I+ G L +F+ Sbjct: 293 EAMRYLKAKIAAGADCIITQMCYRSDTIIQFIKDVRSAGITVPIVVGQLVADSFRTYCLS 352 Query: 224 ADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSRE--GVKDFHFYTLNRAE 281 ++ V +P + ++ DAE +++ +++ + GV FYT N+ Sbjct: 353 ENIAGVHLPPGLRSELLAIESDAERVSQFFIQLSIRIIRDILAADVGVYGVQFYTFNQFA 412 Query: 282 MSYAICHTL 290 A+ L Sbjct: 413 PVQAVLKEL 421 >UniRef50_B2K1S3 Methylenetetrahydrofolate reductase n=22 Tax=Yersinia RepID=B2K1S3_YERPB Length = 266 Score = 194 bits (494), Expect = 3e-48, Method: Composition-based stats. Identities = 55/272 (20%), Positives = 112/272 (41%), Gaps = 12/272 (4%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + +SFE + + + ++ I+ +L P + +V S T+ + ++++T Sbjct: 2 ERKLSFEMNSAKNEKEMENIFKLIEFTDTLDPIYYTVNTEIGSSVWSDTYRTVIELREKT 61 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP-GSGKPEMYASDLVTLLK 140 + PH+T + E+ I Y N GI +RGD P Y +L+ L++ Sbjct: 62 DVSLIPHITINNKKEREIMQIIEKYINVGICEFFVIRGDKHVYDQDNPINYGVELIELIR 121 Query: 141 EVA-DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES---YLRFRD 196 I + YP+ H E + ++ +RK G N I+Q + + + D Sbjct: 122 RSHKHIGIKTSLYPDFHKETTEVKEEIDWNERKYQLGVNEFISQLTLNTNALDFLSHWVD 181 Query: 197 RCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANI 256 + P I+P+ NF +KF ++ P W+ + + + E ++ +G I Sbjct: 182 KER------PFTPSIMPLGNFSFIEKFTSSNSIDYPLWIKKFANSKSNSNEDKENIGIEI 235 Query: 257 AMDMVKILSREGVKDFHFYTLNRAEMSYAICH 288 + + + + H +TLN+ ++ I Sbjct: 236 IRFLCREYLNQRER-LHVFTLNKVDVMKKIFQ 266 >UniRef50_A4J5C2 Methylenetetrahydrofolate reductase n=5 Tax=Clostridiales RepID=A4J5C2_DESRM Length = 598 Score = 194 bits (493), Expect = 4e-48, Method: Composition-based stats. Identities = 62/284 (21%), Positives = 128/284 (45%), Gaps = 20/284 (7%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 +G+ ++ E PP ++ + L N+ +++ + R + I IK Sbjct: 318 KGKFVIAVELDPPFNADTDLILQNAW-ICKDHGVDAITIADSPMARARADSIMIAAKIKR 376 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM------YAS 133 G+E PHL C D + L++ + IR+++A+ GD + K ++ + Sbjct: 377 EVGIEVLPHLCCRDKNLNALKSALLAGYIENIRNVLAITGDPVAIADKNDIKGVFNLNSM 436 Query: 134 DLVTLLKEVADF-----DISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDV 188 L+ L+ + I+V ++ +A+L + +K+++GA +TQ F Sbjct: 437 KLIQLISTMNKELFPEDPINVGG--ALNLNLLKPEAELAKMVKKINSGATFFLTQPIF-- 492 Query: 189 ESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD-MTNVRIPAWMAQMFDGLDDDAE 247 E Y+ R ++ ++I+ GI+P+ ++K A + + ++IP + ++ E Sbjct: 493 EDYVINILRLINKNDGIKILGGIMPLVSYKNALFLNNEVAGIKIPERIINKYNSNMGKDE 552 Query: 248 TRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTL 290 +++G IA+++ + +E V F+F T NR EM I L Sbjct: 553 A-EIIGIEIAVEIANKI-KESVDGFYFITPFNRVEMIMKIIKKL 594 >UniRef50_B9MN09 Methylenetetrahydrofolate reductase n=2 Tax=root RepID=B9MN09_ANATD Length = 605 Score = 192 bits (488), Expect = 1e-47, Method: Composition-based stats. Identities = 61/313 (19%), Positives = 127/313 (40%), Gaps = 38/313 (12%) Query: 6 ASQRDALNQSLAEVQGQ----INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYG 61 Q+ L + +E+ + + E PP+ E+E+T + L V++ Sbjct: 305 EEQKAVLKDTPSELSQKLGKKFIFTVEISPPKGIELEKT-KEGVKLLKEAGADTVNIADS 363 Query: 62 ANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL 121 + R ++ +K+ G+E+ H TC D L++ G+++++AL GD Sbjct: 364 PMARVRISPIALAHILKEELGMESILHFTCRDRNLISLQSELLGAAALGVKNVLALTGDP 423 Query: 122 PPGSGKP------EMYASDLVTL--------------LKEVADFDISVAAYPEVHPEAKS 161 P P ++ + LV + + + +F I VA ++ A Sbjct: 424 PSIGDHPQAKPVFDVNSEGLVLILSRLNNGTDYMGNPIGKATNFTIGVA----LNLNADD 479 Query: 162 AQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAK 221 ++ LK K++ GA+ TQ ++ E+ RF ++ I+ GILP+ + + A+ Sbjct: 480 LGKEIEKLKHKIENGAHFIETQPIYEPETLERFFEKVDFKLP--PILGGILPLRSPRHAE 537 Query: 222 KF-ADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNR 279 ++ + IP + + + A+ G IA ++V+ + + V + + Sbjct: 538 FLHNEVPGITIPDKIRERMRTSKEPAKE----GVEIACEIVEKI-KHMVSGIYIMPPFEK 592 Query: 280 AEMSYAICHTLGV 292 EM+ I + Sbjct: 593 YEMAVEIIRNFKI 605 >UniRef50_A5UUW4 Methylenetetrahydrofolate reductase n=5 Tax=Chloroflexaceae RepID=A5UUW4_ROSS1 Length = 309 Score = 191 bits (487), Expect = 2e-47, Method: Composition-based stats. Identities = 61/295 (20%), Positives = 115/295 (38%), Gaps = 32/295 (10%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLS---SLKPKFVSVTYGANSGERDRTHSIIK 75 G I V+ E PPR + +++RL+ +++T R Sbjct: 12 QAGHIVVTGEIAPPRGAS-----RATVERLALGLRDAVDAINLTDNQRGLGRMSALG-AG 65 Query: 76 GIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM----- 130 I + GLE +TC L+ GI + +A+ GD P P+ Sbjct: 66 IIIRQLGLEPIVQMTCQHRNRIALQADVLSGAACGITNFLAMTGDHPKIGDHPDAKNVLD 125 Query: 131 -YASDLVTLLKEVAD---FDISVAA-----YPEVHPEAKSAQADLLNLKRKVDAGANRAI 181 + L+ +L+ + D F VA + + + + L+RK+ GA Sbjct: 126 LNSFQLLKMLRTMRDEGKFQSGVALTEAPRFFLGGVANPNIER-VARLERKIQFGAEFIQ 184 Query: 182 TQFFFDVESYLRFRDRCVSAGIDVE--IIPGILPVSNFKQAKKFAD-MTNVRIPAWMAQM 238 TQ FD++ + ++ +AG+ + I+ GI+ V + + A+ D + R+P W+ + Sbjct: 185 TQILFDLDRFRQWMADARAAGLHQKAYILAGIMVVKSAQSARFLRDHLPGSRVPEWVIER 244 Query: 239 FDGLDDDAETRKLVGANIAMDMVKILSR-EGVKDFHFYTLNRAEMSYAICHTLGV 292 + E G IA ++ + L EGV+ H ++ + + G+ Sbjct: 245 MERAAHPEEE----GIAIAAELAQELLAIEGVRGVHIMSVGWTKAIPQVVARAGL 295 >UniRef50_A5ZMW8 Methylenetetrahydrofolate reductase n=4 Tax=Clostridiales RepID=A5ZMW8_9FIRM Length = 292 Score = 190 bits (482), Expect = 7e-47, Method: Composition-based stats. Identities = 65/289 (22%), Positives = 116/289 (40%), Gaps = 29/289 (10%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 +G+ VS E PP+ +++ + + L + V+VT +S R + ++ K +KD Sbjct: 9 RGEFVVSAEVGPPKGIHVDELVEEAKTYLKDVHA--VNVTDNQSSVMRLGSLAMCKVLKD 66 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASDLV 136 G++ L C D L + GI +I+ L GD P+ ++ D V Sbjct: 67 -AGMDPIFQLACRDRNRIALESDLLSAAMFGIENILCLTGDHTKMGDHPQAKPVFDLDSV 125 Query: 137 TLLKEVADFDISV-------AAYPE-------VHPEAKSAQADLLNLKRKVDAGANRAIT 182 +LL V + V P V P + S A L ++RKV AGA+ T Sbjct: 126 SLLHTVKLLESGVDLGGNELVGEPPKFSKGAVVSPCSDSVDAQLAKMERKVAAGADYFQT 185 Query: 183 QFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDG 241 Q F+ E +++F ++ G + GI+ + + ++ + +P +M + Sbjct: 186 QAVFEPEKFIKFMEKAKQFGK--PVQVGIIIPKSVGMVRFMNNNVAGIHVPD---EMIEE 240 Query: 242 LDDDAETRK--LVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICH 288 L D E K + G IA ++K + + H L + Sbjct: 241 LKADKEKTKAGITGVEIAARIIKE-CKPYCQGVHIMALGWESKIPDLLK 288 >UniRef50_A8ZTK4 Methylenetetrahydrofolate reductase n=24 Tax=Bacteria RepID=A8ZTK4_DESOH Length = 321 Score = 188 bits (478), Expect = 2e-46, Method: Composition-based stats. Identities = 62/300 (20%), Positives = 116/300 (38%), Gaps = 34/300 (11%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G + E PPR +++E+ + R ++T + R + + + Sbjct: 13 AGHFAFTGEIGPPRGTDVEEVKEKA--RFLKGNVDMANITDNQTAVVRMSSWAT-SLVVM 69 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASD-- 134 G+E + C D ++ + GIR+I+AL GD P +Y D Sbjct: 70 EEGVEPNYQMVCRDRNRLAMQADILGAYALGIRNILALSGDHQQFGDHPFAKGVYDLDSI 129 Query: 135 -LVTLLKEVAD---------------FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGAN 178 LV ++K + D I AA +P A+ + + L +K+DAGA+ Sbjct: 130 QLVNMIKNMRDEGKFQGGADISHPPKMFIGAAA----NPFAEPYEWRVHRLAKKIDAGAD 185 Query: 179 RAITQFFFDVESYLRFRDRCVSAGIDVE--IIPGILPVSNFKQAKKF-ADMTNVRIPAWM 235 TQ F++E + + + G+ + I+ GI P+ + A+ + + +P + Sbjct: 186 FVQTQCIFNMERFREWIRQANDMGLTEKIYILGGITPMKSIGMARYMQKKVPGMDVPEAI 245 Query: 236 AQMFDGLDDDAETRKLVGANIAMDMVKILSR-EGVKDFHFYTLNRAEMSYAICHTLGVRP 294 + G+ D + G IA + ++ L +GV H + I G+ P Sbjct: 246 IKRLQGV--DKKEVANEGIKIACEQIQELKETKGVAGVHLMAIEWEHKVPEIAEKAGMLP 303 >UniRef50_A7VPD0 Methylenetetrahydrofolate reductase n=1 Tax=Clostridium leptum DSM 753 RepID=A7VPD0_9CLOT Length = 600 Score = 188 bits (477), Expect = 2e-46, Method: Composition-based stats. Identities = 63/299 (21%), Positives = 122/299 (40%), Gaps = 27/299 (9%) Query: 6 ASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG 65 A Q Q L +G ++ E PP S L + L + V+++ + Sbjct: 310 APQESRFAQKLR--KGDFVMAAELDPPYGSR-VDKLLTACRVLQNSGVDIVTISDSPMAR 366 Query: 66 ERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS 125 + ++ TG+E PH C D + LR + IR I+A+ GD P Sbjct: 367 VKLDPVVCGAKLQRETGMEVLPHFCCRDRNVNALRAMLLGAQCENIRTILAVTGDHVPEL 426 Query: 126 GK------PEMYASDLVTLLKEVAD-------FDISVAAYPEVHPEAKSAQADLLNLKRK 172 + + ++ L+ ++ ++ F I A +P + +A+L L++K Sbjct: 427 DRGYIKPVFNVTSAKLMEMISQMNQDVFADSPFTIGGA----FNPNVANPKAELARLEKK 482 Query: 173 VDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD-MTNVRI 231 + AGA +TQ FD ++ + + +++ GI+P+ +++ A + + ++I Sbjct: 483 LKAGAVFFLTQPVFDEGRISTVKE---AREMGAKMLLGIMPLVSYRNAVYMNNEVPGIQI 539 Query: 232 PAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHT 289 P F E ++ G IA+++ + L F+F T NRAE+ + Sbjct: 540 PTAYVNRFSPEMSREEAQR-TGIEIALEIAESLRPH-ADGFYFMTPFNRAEIVAELIEK 596 >UniRef50_B2Q6I6 Methylenetetrahydrofolate reductase n=1 Tax=Providencia stuartii ATCC 25827 RepID=B2Q6I6_PROST Length = 273 Score = 187 bits (475), Expect = 4e-46, Method: Composition-based stats. Identities = 59/271 (21%), Positives = 114/271 (42%), Gaps = 10/271 (3%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + +SFE S+++ TL + + L P F +V E T++ +K+ T Sbjct: 10 ETALSFEISA--MSKIDNTLEHLLKNTEELTPLFYTVNTEIGKTEWRDTYNTCCELKNLT 67 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP-GSGKPEMYASDLVTLL- 139 + PH+ + EL I +Y N I + +RGD P Y +L+ + Sbjct: 68 HVNVVPHIAINNKDECELCFIIEEYLKNDITELFVIRGDRHRFDEELPFNYGIELIDFIR 127 Query: 140 KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199 + + I + YP+ H E+ + + ++ L++K+ G I+Q + ++ + + Sbjct: 128 RRYPEVMIKSSIYPDYHKESITPEIEIDWLRKKLQLGVTELISQLCLNKNAFSYMKKQL- 186 Query: 200 SAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMD 259 G D+ I ++P+ NF + F + P W+ + + + G + Sbjct: 187 --GNDIPITISMMPMLNFSFIESFFKNNAIDYPLWIKKHIRP--SNINNHRAFGIQLTQF 242 Query: 260 MVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 ++ +E K HF+TLN AEM + L Sbjct: 243 LIGEYIKEN-KRLHFFTLNNAEMVKKLFDKL 272 >UniRef50_B7RVE0 Methylenetetrahydrofolate reductase n=1 Tax=marine gamma proteobacterium HTCC2148 RepID=B7RVE0_9GAMM Length = 293 Score = 186 bits (474), Expect = 6e-46, Method: Composition-based stats. Identities = 62/295 (21%), Positives = 106/295 (35%), Gaps = 35/295 (11%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G V+ E PP+ ++ L + L+ +VT S + + Sbjct: 10 AGHFVVTGELTPPKGTD-ISGLKARAELLAD-HIDAFNVTDSHASKMSLSPMAAAHEL-T 66 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS------ 133 G+E +T D L++ W G++++V + GD P PE Sbjct: 67 VLGVEPILQMTIRDRNRIALQSDMLGAWLLGVKNLVCMGGDPPHLGDHPEAKPVFDISTE 126 Query: 134 DLVT--------------LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANR 179 DL+ LL F I V+P A+ ++ L+ KV AGA Sbjct: 127 DLIQAAGNLNNGKDMMDNLLSGSTGFHIGAV----VNPGAEDLDKEIARLESKVAAGAKF 182 Query: 180 AITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQM 238 TQ FD + + F +R +D+ I+ GI+P+ + K A + + +P + Sbjct: 183 FQTQAIFDADRFAGFMERVSH--LDIAILAGIMPIKSVKMAAFMNEKIPGIDVPDHVIDR 240 Query: 239 FDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 DG D +A +++K + + H L E + GV Sbjct: 241 IDGAAD----TVKESTAVAAEIIKEIKPI-CQGIHVMALGWEEHIPGVLQLAGVT 290 >UniRef50_Q189R6 Methylenetetrahydrofolate reductase n=6 Tax=Clostridium RepID=Q189R6_CLOD6 Length = 293 Score = 185 bits (470), Expect = 2e-45, Method: Composition-based stats. Identities = 62/295 (21%), Positives = 119/295 (40%), Gaps = 33/295 (11%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G+ V+ E PP+ +++ + + + + +VT ++ R + + K +KD Sbjct: 10 SGKFAVTTEMAPPKGTDLSHLIECAKPLVGRVHAA--NVTDFQSAVMRATSLATCKLLKD 67 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASDLV 136 GLE +T D ++ GI +++AL GD P+ ++ D V Sbjct: 68 -AGLEPVIQITGRDRNRIAIQGEMLSAGVFGINNLLALTGDHTSVGDHPQAKGVFDLDSV 126 Query: 137 TL-----------------LKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANR 179 + LK DF + + PE P + LL +K+K+ AGA Sbjct: 127 GILQTAETLMAGTDMAGNKLKGSPDFYLGASVTPEYSP----IEVQLLKMKKKIKAGAKF 182 Query: 180 AITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQM 238 TQ +D+ + +FR+ +D +++ GI+P+ + AK A++ + +P + Sbjct: 183 FQTQALYDINTMRKFRELTRD--MDCKVLAGIVPLKSPGMAKFMTANVPGIFVPDEQIER 240 Query: 239 FDGLDDDAETRKLVGANIAMDMVKILSREG-VKDFHFYTLNRAEMSYAICHTLGV 292 + + G +A +++K L E H + E AI G+ Sbjct: 241 LRAAGKENWVSE--GIKMAGELIKQLKEEDLCDGVHIMAIGAEENIPAILDAAGL 293 >UniRef50_C4GEB4 Methylenetetrahydrofolate reductase n=1 Tax=Shuttleworthia satelles DSM 14600 RepID=C4GEB4_9FIRM Length = 670 Score = 183 bits (465), Expect = 7e-45, Method: Composition-based stats. Identities = 54/304 (17%), Positives = 130/304 (42%), Gaps = 21/304 (6%) Query: 2 SFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYG 61 + +DA Q L + G+ V+ E PR ++ + + + L +++ Sbjct: 370 GLSVSKDQDAFYQKL--MSGRKVVAVELDSPRGCDITR-FMEAAENLKEAGADIITIADN 426 Query: 62 ANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL 121 + R + + I+ + GL+A PH+TC D + +++ + GIR+++ + GD Sbjct: 427 PIAKARMDSSIVAGIIRRQVGLDALPHMTCRDRNLNATKSLLLGNYAQGIRNVLVITGDP 486 Query: 122 PPGSGKPEM------YASDLVTLLK----EVADFDISVAAYPEVHPEAKSAQADLLNLKR 171 P + + E+ + L+ +K E F + + ++ A++ + +L + Sbjct: 487 IPSARRDEVKVVYQFNSRKLMAYMKALGQEEGTFPSPMHIFGALNVNARNFEIELDRARE 546 Query: 172 KVDAGANRAITQFFFDVES---YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMT 227 KV AGA +TQ E+ R + + + ++ GI+PV + + + ++++ Sbjct: 547 KVQAGAVGFLTQPALTTEAIANICRASETLRAENSRIRLLGGIIPVISERNGRFMQSEIS 606 Query: 228 NVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAI 286 + +P + + + + D + + + ++++ K + V ++ T R + I Sbjct: 607 GIDVPDALIERY--VGKDRADCEEIAVDSSLELAKTMEDA-VDGYYLVTPFMRDYLIRRI 663 Query: 287 CHTL 290 L Sbjct: 664 MERL 667 >UniRef50_D0LSQ2 Methylenetetrahydrofolate reductase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LSQ2_HALO1 Length = 643 Score = 181 bits (460), Expect = 2e-44, Method: Composition-based stats. Identities = 63/300 (21%), Positives = 111/300 (37%), Gaps = 25/300 (8%) Query: 7 SQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE 66 + R L LA GQ VS E P ++ + L +I L V++ G + Sbjct: 329 AMRSRLGARLA--AGQFAVSVELTAPAGTD-DSKLLGNIRTLLEAGVDVVNIADGPRASA 385 Query: 67 RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG 126 R ++ ++ TG+E H+ D L GIR++V + GD P Sbjct: 386 RTGNLAVCTKLQATTGVEPILHVCTRDRNYLGLIAHLLGAHALGIRNMVIITGDPPKMGD 445 Query: 127 KPE---MYASDLVTLLKEVADFDIS---VAAYPEVH----------PEAKSAQADLLNLK 170 P +Y D + LL+ + + H P A + ++ L+ Sbjct: 446 YPFATPVYDVDSIGLLRMARTLNEGYDPAGKEIDGHTSFVLATGAEPAATDYEREMRRLE 505 Query: 171 RKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNV 229 K AGA +TQ +D RF D G+ ++ GILP+++ + A+ ++ + Sbjct: 506 DKRAAGAELVMTQPVYDPRVLERFLDDAEPLGL--PVMVGILPLASHRNAEFLHNEVPGM 563 Query: 230 RIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMSYAICH 288 +IP + + E + G IA + + V + NR + + Sbjct: 564 QIPQSYRDRMEKVGSGPEA-RAEGVRIAQE-ALEAVKHRVAGVYIMPPFNRVSSAIEVLD 621 >UniRef50_A8SCX4 Methylenetetrahydrofolate reductase n=3 Tax=Clostridiales RepID=A8SCX4_9FIRM Length = 605 Score = 180 bits (458), Expect = 4e-44, Method: Composition-based stats. Identities = 54/293 (18%), Positives = 121/293 (41%), Gaps = 18/293 (6%) Query: 10 DALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDR 69 DA + L GQ ++ E P+ +++ L + RL + +++ + R Sbjct: 313 DAFLRKLR--AGQRVIAVELDSPKDADLTAYLEGA-RRLQAAGADLLTIADCPIARARMD 369 Query: 70 THSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE 129 + + + G+ PH+TC D + + + + G+R ++A+ GD P + + E Sbjct: 370 SSLVACRVHRELGMNVLPHMTCRDRNLNATKALLLGLYAEGVREVLAITGDPIPTAERDE 429 Query: 130 MY----------ASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANR 179 + A +V+L E + + + ++ A++ + +L K++ G + Sbjct: 430 VKNVYQFNSRKLAQYIVSLAGEGREMPSPITVFGALNLNARNFEVELRRAAEKLENGMSG 489 Query: 180 AITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD-MTNVRIPAWMAQM 238 +TQ ++ + + G +I+ GILPV + + A + + + + + Q Sbjct: 490 FLTQPVLSAQAVENLKKTRETLGERAKILAGILPVVSQRNAIFMENEVNGIHVDDAIIQR 549 Query: 239 FDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTL 290 F+GL D + +G +++ + V F+ T NR + + L Sbjct: 550 FEGL--DRAAGEELGLEVSV-QAAKAAAPYVDGFYLMTPFNRVALMERLIARL 599 >UniRef50_Q9VTI0 Methylenetetrahydrofolate reductase n=6 Tax=melanogaster group RepID=Q9VTI0_DROME Length = 349 Score = 180 bits (457), Expect = 5e-44, Method: Composition-based stats. Identities = 55/263 (20%), Positives = 106/263 (40%), Gaps = 29/263 (11%) Query: 50 SLKPKFVSVTYGA------NSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIA 103 L P FVS + + + + + + + T + PH++ + L Sbjct: 76 PLLPTFVSFVWLSQRYWDVEPVGQVESLQMAQHLA--TRIPVLPHVSAYRMSRQRLDQFL 133 Query: 104 RDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTL-LKEVAD-FDISVAAYPEVHPEAKS 161 ++A+RGD + + +V +++ + + V YPE + Sbjct: 134 ----ALNFSSLLAVRGDRVH-EDQDFSISYPMVEQSIRQRGETISVCVGGYPEGYTSLGD 188 Query: 162 A----QADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNF 217 ++ LK K+DAGA+ ITQ + E ++F C +AGI V I+ G++ +F Sbjct: 189 IPQNSAKNMEFLKAKIDAGADCIITQLCYRPEVIVQFVKDCRAAGISVPIVVGLMSHESF 248 Query: 218 KQAKKFADMTNVRIPAWMAQMFDGL--------DDDAETRKLVGANIAMDMVKILSRE-- 267 + +T V +P + + D L D + + ++ + ++ + Sbjct: 249 RSYSMIEQITGVHLPDDLREQLDQLHSAHMKDMKSDQDLIRRFFVSLTVRTIRNVLDADV 308 Query: 268 GVKDFHFYTLNRAEMSYAICHTL 290 GV FHF+TLNR + A+ L Sbjct: 309 GVWGFHFFTLNRFKSVQAVLQEL 331 >UniRef50_B1GYU6 Methylenetetrahydrofolate reductase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=B1GYU6_UNCTG Length = 287 Score = 180 bits (456), Expect = 6e-44, Method: Composition-based stats. Identities = 61/289 (21%), Positives = 102/289 (35%), Gaps = 35/289 (12%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 + ++ E FPP+ + + D L L V+VT + R + ++ I Sbjct: 11 SDKFLITAELFPPKGVD-ISSFLRRADCLYGL--DAVNVTDNQRASMRVSSLAM-SRILI 66 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP---GSGKPEMYASDLV 136 +E LT D L++ GI +++ L GD P S +Y D + Sbjct: 67 ERAIEPILQLTARDRNRISLQSELLGANVLGIENVLLLSGDHPSIGECSDAKAVYDLDTI 126 Query: 137 TLLKE-----------------VADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANR 179 L+K F + V+P +S L L++KV AG Sbjct: 127 QLIKTARLLETGVDIAGKKLQGSPKFCVGAV----VNPSVQSVDLQALMLEKKVKAGTEF 182 Query: 180 AITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMF 239 TQ FDV+ Y F D+ + V+I+PG++ + + K + M+ V IP + Sbjct: 183 FQTQAIFDVQIYKNFFDKVKH--LKVKILPGMILIKSPKFLQFLKSMSGVNIPDEIKDRI 240 Query: 240 DGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICH 288 + D I +K L H + E + Sbjct: 241 NSASDPLAE----SIKICSATIKELRSF-ADGVHIMAIGTEEHIPEMIR 284 >UniRef50_B4MKM9 Methylenetetrahydrofolate reductase n=1 Tax=Drosophila willistoni RepID=B4MKM9_DROWI Length = 318 Score = 179 bits (454), Expect = 1e-43, Method: Composition-based stats. Identities = 49/249 (19%), Positives = 100/249 (40%), Gaps = 22/249 (8%) Query: 53 PKFVSVTYGANS-----GERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYW 107 P FVS+ + S + + + + K + + + HL+ T + L Sbjct: 74 PAFVSLVWLGISYWNIPMDENYSLQLAKHM--ESHIPVLAHLSAYRMTEERLNEFL---- 127 Query: 108 NNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVA--DFDISVAAYPEV-HPE-AKSAQ 163 R+++ +RGD G+ Y +++ ++ + I V YPE H Sbjct: 128 AKNFRNVLIVRGDEIH-EGQKFTYGREMIEYARQQRKDNLSIGVPGYPEGYHKNPINDPI 186 Query: 164 ADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF 223 ++ LK K+ AG ITQ + + ++F + C A + V II GI+ + + Sbjct: 187 LNIQYLKEKISAGGEFIITQTCYSSQKIIQFINDCREANVTVPIIIGIMVPDSVRNYHIV 246 Query: 224 ADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSRE--GVKDFHFYTLNRAE 281 ++T R+P + L +A+ ++ + ++ + G++ F+T+NR Sbjct: 247 KNITGARLPNEVND----LSVNADDILKFFVDLTVRNIRDIFTANLGIQGIQFFTMNRFR 302 Query: 282 MSYAICHTL 290 + L Sbjct: 303 PVQMVLDEL 311 >UniRef50_B0PF81 Methylenetetrahydrofolate reductase n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PF81_9FIRM Length = 582 Score = 178 bits (452), Expect = 2e-43, Method: Composition-based stats. Identities = 56/284 (19%), Positives = 108/284 (38%), Gaps = 24/284 (8%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + ++ E PP + L + L + ++VT S R + I+ Sbjct: 303 RKEIAVELDPPFDHDCSFVL-AAASELRACGVDLITVTDSPLSRTRADSLMTAAKIRREA 361 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYASDL 135 G+E PH++C D LR GI ++ + GD P +G + + DL Sbjct: 362 GIEVMPHISCRDKNHIALRAGLLGAAFEGIGRVLIVTGDPPMQAGTRGSDGVYHLSSYDL 421 Query: 136 VTLLKEVA-------DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDV 188 + + + F I A ++ A + A+L K+K+ GA+ TQ F Sbjct: 422 IAWIHSMNSEVFADAPFLIGGA----LNVNAANFDAELARAKKKLSLGASMLFTQPIFSD 477 Query: 189 ESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKK-FADMTNVRIPAWMAQMFDGLDDDAE 247 ++ F R D + GILPV+ +K A +++ + IP + + +G D Sbjct: 478 KAVDHFL-RARQELKDCRLFAGILPVAGYKNALFLINEVSGIEIPDNVVRSLEGKTPDEA 536 Query: 248 TRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTL 290 + + +++ + F+ T L + + + + Sbjct: 537 A--AISVAYSAGIMRRVYDA-ADGFYIMTPLKKVNIVRGLIEEI 577 >UniRef50_A9FZY9 Methylenetetrahydrofolate reductase n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9FZY9_SORC5 Length = 624 Score = 178 bits (452), Expect = 2e-43, Method: Composition-based stats. Identities = 65/302 (21%), Positives = 117/302 (38%), Gaps = 26/302 (8%) Query: 8 QRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGER 67 +R L +A G+ VS E P E L ++ L V+V G + R Sbjct: 327 ERSPLAAKIA--AGKFVVSVEVNPAPGLNPESAL-SAAKMLIDSGVDVVNVADGPRATAR 383 Query: 68 DRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK 127 + + R G+E H+ D GI+++V + GD P Sbjct: 384 MTNLAFCSLLVQRYGIEPILHVCGRDRNLIGQMAHLLGAHAIGIKNLVIITGDPPKVGDY 443 Query: 128 PE---MYASDLVTLLKEVADFDISV--AAYP------------EVHPEAKSAQADLLNLK 170 PE +Y D + LL + + + A P + P A+ ++ L+ Sbjct: 444 PEATAVYDLDSIGLLHMASTMNRGLDPAGKPIPGGKTSFLLATGLEPGAQDLDKEIARLE 503 Query: 171 RKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNV 229 RK AGA+ +TQ F + + R G+ ++ G+LP+ + K A+ ++ + Sbjct: 504 RKRAAGADIIMTQPVFHQDLLEKVLRRIEHLGM--PVLVGVLPLVSHKNAEFLHNEVPGM 561 Query: 230 RIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMSYAICH 288 +IP + + + E RK G IA +M+ + V+ + L + E++ + Sbjct: 562 QIPEEIRERMRKVPAGPEARKE-GVKIAREMLFSVRDR-VQGAYLMPPLGKYELALEVLD 619 Query: 289 TL 290 L Sbjct: 620 GL 621 >UniRef50_D1N227 Methylenetetrahydrofolate reductase n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N227_9BACT Length = 605 Score = 178 bits (452), Expect = 2e-43, Method: Composition-based stats. Identities = 65/303 (21%), Positives = 113/303 (37%), Gaps = 33/303 (10%) Query: 7 SQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE 66 ++R + LA+ G E PPR ++ T+ + + V++ G + Sbjct: 313 AERSRIGCKLAD--GAFIKLVEITPPRGFDLTGTIAGAAKC-KAAGIDAVNLPDGPRASA 369 Query: 67 RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG 126 R I+ G+E H C D + L+ GI +I+ + GD P Sbjct: 370 RISPLVTALEIQRNAGIETILHCCCRDKSLIGLQADLLGCAGVGINNILFITGDPPKLGD 429 Query: 127 KPE---MYASDLVTLLK-----------------EVADFDISVAAYPEVHPEAKSAQADL 166 P ++ D V L+K V I V A P A + + Sbjct: 430 YPFSSGVFDVDSVGLVKIQKRMNQGVDLGGKPLNAVTKMVIGVGA----DPNAIDLEREY 485 Query: 167 LNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-AD 225 KV+AGA ITQ F E+ F DR A ++V +I GI P+++ + A+ + Sbjct: 486 RRTCEKVEAGAEFIITQPVFAPEALFVFLDRV--AHLNVPVIAGIWPLTSLRNAEFMRTE 543 Query: 226 MTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSY 284 + V +P + + D+ E ++ G IA + V + V+ + + Sbjct: 544 VPGVVVPDAVMERM-AADESKEAQREAGIAIARESVAAIRSR-VRGIQVSAPFGNVDTAL 601 Query: 285 AIC 287 + Sbjct: 602 RVL 604 >UniRef50_Q12UZ6 Methylenetetrahydrofolate reductase n=4 Tax=Methanosarcinaceae RepID=Q12UZ6_METBU Length = 294 Score = 177 bits (449), Expect = 4e-43, Method: Composition-based stats. Identities = 59/289 (20%), Positives = 110/289 (38%), Gaps = 24/289 (8%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 + V+ E PP+ +++ TL ++ L +++T + R ++ K + Sbjct: 11 SDRFIVTAEVAPPKGTDISATLEDA--ELIRGLVDAINITDNQRAVMRMSPIAVGK-LLM 67 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK---PEMYASDLV 136 G E LTC D L++ GI ++ + GD +Y D V Sbjct: 68 DAGHEVIVQLTCRDRNRLALQSDILAASALGIENLCVMTGDYTTKGDHVGAKAVYDLDSV 127 Query: 137 TLLKEVADFDIS-------VAAYPEVHPEAKS-----AQADLLNLKRKVDAGANRAITQF 184 LL + +A P A S + +L LK+K++AGA TQ Sbjct: 128 QLLSLITKMMGGSDMAGNELAGAPSFTVGAVSNTDVTKRMQMLKLKKKINAGARFIQTQA 187 Query: 185 FFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLD 243 +DVES+ F D G +V ++ GI+P+ + A ++ +R+ + + + Sbjct: 188 VYDVESFKDFSDLMGQIGPNVLVLAGIIPLRSAAMAHFMNNNIPGIRVGDELIKRMENAK 247 Query: 244 DDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 D + G IA + + L + H + + + G+ Sbjct: 248 DPIQE----GLEIAAESILELRDL-CRGIHLMPIGGHGNTQRLLEMAGL 291 >UniRef50_B8FFJ4 Methylenetetrahydrofolate reductase n=4 Tax=Bacteria RepID=B8FFJ4_DESAA Length = 295 Score = 177 bits (449), Expect = 5e-43, Method: Composition-based stats. Identities = 58/295 (19%), Positives = 111/295 (37%), Gaps = 33/295 (11%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 QG+ V+ E PP+ +E+ + L K ++VT +S R + + Sbjct: 11 QGKFVVTSEVAPPKGVNLEKMAHHI--ELLKDKVDAMNVTDHQSSVMRFPSLG-AALMVK 67 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK------PEMYAS 133 G E +TC D L+ GI +++ L GD ++ +S Sbjct: 68 EMGGEPILQMTCRDRNRLALQADLLFAHQRGINNVLCLTGDSVVLGDHKTAKGVFDLDSS 127 Query: 134 DLVTLLKEVAD--------------FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANR 179 LV ++++ F PE +P Q L+ ++K++AGA Sbjct: 128 QLVAAVRKLEKGKDMAGNDLDGAVSFCAGAIVTPEANP----IQPQLIKFEKKIEAGAEF 183 Query: 180 AITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNVRIPAWMAQM 238 TQ +D+E++ F + V+++ GI+ +++ A+ ++ V +P Sbjct: 184 IQTQAVYDLENFKNFMEYARQ--FPVKVLAGIILLTSAPMARFMNKNVAGVTVPQVFIDE 241 Query: 239 FDGLDDDAETRKLVGANIAMDMVKILSREGV-KDFHFYTLNRAEMSYAICHTLGV 292 +K G IA +K + E + H + + E+ I G+ Sbjct: 242 MASAPKGGAIKK--GIEIAGRQIKQIVEENICDGVHIMAIGKEELVPDIMAAGGL 294 >UniRef50_B9XKW8 Methylenetetrahydrofolate reductase n=1 Tax=bacterium Ellin514 RepID=B9XKW8_9BACT Length = 624 Score = 176 bits (448), Expect = 6e-43, Method: Composition-based stats. Identities = 56/285 (19%), Positives = 114/285 (40%), Gaps = 24/285 (8%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 + + + E PP++ +++ L + L FV++ + + R + +K+ Sbjct: 322 REKPIIVTELDPPKSLSLDKLLEGA-QALKQAGTDFVTLADNSLAILRVSNMAAGFLVKE 380 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASDLV 136 +TG E HL C D L++ GI H++AL GD E +Y + V Sbjct: 381 KTGAEPLIHLACRDKNLIGLQSELMGLHALGIDHVLALTGDPAKVGDHQEATSVYDVNSV 440 Query: 137 TLLKEVADFDISVAAYP-------------EVHPEAKSAQADLLNLKRKVDAGANRAITQ 183 L++ + + AA +P A++ + + L+ K++AGA +TQ Sbjct: 441 GLIRMIKRLNEGFAANGRDLKTKTQFVIGCAFNPNARNLDSQVRKLEDKLEAGAQFVMTQ 500 Query: 184 FFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGL 242 FD L + G+ V ++ G++P+ N + A+ ++ + IP G Sbjct: 501 PIFD--PVLAKVTHEKTKGLGVPVLVGVMPLLNSRNAEFLHNEVPGIIIPEMTRDRLRGK 558 Query: 243 DDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAI 286 + G I+ ++ + + T L R +++ + Sbjct: 559 EG--AQANAEGLAISRELCDAVLDC-FNGIYLITPLMRYDLTVEL 600 >UniRef50_C6VPC5 Methylenetetrahydrofolate reductase n=3 Tax=Lactobacillus plantarum RepID=C6VPC5_LACPJ Length = 618 Score = 171 bits (435), Expect = 2e-41, Method: Composition-based stats. Identities = 53/286 (18%), Positives = 114/286 (39%), Gaps = 29/286 (10%) Query: 27 FEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEAA 86 E PPR + + + +RL + ++++ + + R +I +K G+ Sbjct: 331 VELDPPRDFDTTK-FFRGAERLKAAGVDGITLSDNSLATVRIANTTIAAQLKLNYGITPI 389 Query: 87 PHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYASDLVTLLK 140 HLT D L++ + GI I+A+ GD P ++ + +L+ L+K Sbjct: 390 VHLTTRDHNLIGLQSEIMGLHSLGIEDILAITGDPAKLGDFPGATSVSDVRSVELMKLIK 449 Query: 141 EVA--------------DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFF 186 + DF ++ A P + + S ++ + RK+ G + ITQ + Sbjct: 450 QFNSGIGPTGKSLKEASDFRVAGAFNPNAYRTSISTKS----ISRKLSYGCDYIITQPVY 505 Query: 187 DVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDDD 245 D+ + D + ++V + G++P+ + + A+ ++ +RIP + + Sbjct: 506 DLANVDALADALAANHVNVPVFVGVMPLVSRRNAEFLHHEVHGIRIPEPILTRMAEAEQT 565 Query: 246 AETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTL 290 + VG IA +++ + H T NR + + + Sbjct: 566 GNE-RAVGIAIAKELIDGICAR-FNGVHIVTPFNRFKTVIELVDYI 609 >UniRef50_Q1AXR8 Methylenetetrahydrofolate reductase n=2 Tax=Bacteria RepID=Q1AXR8_RUBXD Length = 611 Score = 171 bits (433), Expect = 3e-41, Method: Composition-based stats. Identities = 64/292 (21%), Positives = 126/292 (43%), Gaps = 32/292 (10%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 G V+ E PR +++ + + RL + ++ GA + R + + +++R Sbjct: 329 GGFAVAVEVDLPRGNDLSGVV-EAARRLKERGADAIDISDGARARLRMHPVAAARIVQER 387 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL------PPGSGKPEMYASD 134 G+EA H++C D L+ G+R+I+A+ GD P +G + A Sbjct: 388 AGIEAVAHMSCRDRNILGLQADLLAAAALGVRNILAVTGDPAQIGDYPEATGVFDTDAVG 447 Query: 135 LVTLLKEVA--------------DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRA 180 LV +L + F I A +P A+ A++ L+RK++AGA+ Sbjct: 448 LVHILSRMNRGEDLAGNAIGRPPGFLIGAA----FNPTAEDLDAEVERLRRKLEAGAHAF 503 Query: 181 ITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMF 239 TQ F++ + R +R G ++ G++P+ + +QA+ ++ V+IPA + + Sbjct: 504 WTQPVFELPALERALERLE--GTGARLLLGLMPLRSARQAEFLHHEVPGVKIPAEVRRKL 561 Query: 240 DGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMSYAICHTL 290 L R G +A +++ +R V + + E++ + L Sbjct: 562 AELSPQDAPR--YGVEVAGNLLAR-ARPLVSGAYIMPPASAPELAAEVMEAL 610 >UniRef50_B7AQD9 Methylenetetrahydrofolate reductase n=1 Tax=Bacteroides pectinophilus ATCC 43243 RepID=B7AQD9_9BACE Length = 603 Score = 170 bits (432), Expect = 4e-41, Method: Composition-based stats. Identities = 58/280 (20%), Positives = 115/280 (41%), Gaps = 20/280 (7%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G V+ E PP ++ ++ + + L S+ ++ R + + + Sbjct: 326 SGHKVVAVELDPPYDAKYDRLIEQA-QYLKSIGVDILTFADSPMGRSRVDSVLMSLKVTQ 384 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG------SGKPEMYAS 133 TG+ PH+ C D +R+ + NGIR ++ + GD P +G + + Sbjct: 385 ETGMMVMPHVCCRDKNVIAMRSTLLGAYINGIRQLLLVTGDPVPSVSRVSTTGVFDYNSI 444 Query: 134 DLVTLLKEVADFDISVAAYPEVHPEAKS-----AQADLLNLKRKVDAGANRAITQFFFDV 188 L+ +KE+ A P + A + + +++K+D GA+ +TQ F Sbjct: 445 RLMNFVKEMNQEHF--ADEPLYYGGALNVTLGRIDRIMERMQKKIDNGASYFMTQPVFSK 502 Query: 189 ESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDDDAE 247 E R + +D +I+ GI+P+ +++ A + + +P + + D E Sbjct: 503 EGIERL--AIIKEKMDTKILCGIMPLVSYRNANFIKNEFIGIDVPDEIVARYSP-DMSKE 559 Query: 248 TRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMSYAI 286 + VGA IA +++ + V F+F NR + I Sbjct: 560 EGEAVGAQIANELIGQMYDY-VDGFYFMLPFNRVSLMDKI 598 >UniRef50_Q1NSQ8 Methylenetetrahydrofolate reductase n=3 Tax=Deltaproteobacteria RepID=Q1NSQ8_9DELT Length = 704 Score = 170 bits (431), Expect = 5e-41, Method: Composition-based stats. Identities = 60/288 (20%), Positives = 118/288 (40%), Gaps = 31/288 (10%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 ++ + E PP +M L + L++ +S+ + R ++ I+ Sbjct: 405 RMPILVELDPPTHLDMGGVLEGA-KALAAGGTDAISLGESPLAVLRTENLALAHRIQQEA 463 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYASDL 135 G++ HLTC D L++ GI I+A+ GD S +P ++ + L Sbjct: 464 GIKTIIHLTCRDRNALGLQSHIMGAHLLGIDSILAVTGDPATSSDQPGVSGVFDVRSFGL 523 Query: 136 VTL--------------LKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAI 181 V + +KE DF + VA + Q + L+RK GA + Sbjct: 524 VRMIDRFNQGFNMAGKNIKEKTDFSLGVA----FSYRPSNPQVQIKRLERKAALGARYVM 579 Query: 182 TQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFD 240 TQ FF + ++ ++ +D+ I PGI P+ + + A ++ + IPA + Q Sbjct: 580 TQPFFAADEVEAMMEK--TSHLDLLIFPGIFPLISARNADFLHNEVPGISIPATLRQKLH 637 Query: 241 GLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAIC 287 + E ++ V + ++V+ +S + + LN+ E++ + Sbjct: 638 QY-EQVEDQRRVAMDFTRELVEKISSFS-DGLYLISPLNKWEVANDLV 683 >UniRef50_A9QPD6 Methylenetetrahydrofolate reductase n=1 Tax=Methylacidiphilum infernorum V4 RepID=A9QPD6_METI4 Length = 617 Score = 169 bits (430), Expect = 8e-41, Method: Composition-based stats. Identities = 56/291 (19%), Positives = 106/291 (36%), Gaps = 32/291 (10%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + E+ P+T M + + +++ + + R + ++ + Sbjct: 331 KPVFMVEYDSPKTLSM-GKFLEGVKAIEKAGADALTLADNSLAILRVSNFAAAIHVRRVS 389 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYASDL 135 L H+ C D L++ G RHI+AL GD P ++ + L Sbjct: 390 KLIPVLHVACRDRNLLGLQSELMGLGTLGFRHILALTGDPAKSGDHPGATSVYDLNSVGL 449 Query: 136 VTL--------------LKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAI 181 + L LK DF I A +P A + L+ K+ AGA + Sbjct: 450 IRLLAGLNRGVNAAGKDLKGKTDFIIGCA----FNPNTVQFDAQVRKLEAKLAAGARFVM 505 Query: 182 TQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFD 240 TQ FD E + + G V + GI+P+ N++ A+ ++ + IP + Sbjct: 506 TQPVFDFELIKKIFNYLKPLG--VPVFVGIMPILNYRNAEFLHNEVPGISIPEKIRSRMK 563 Query: 241 GLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTL 290 L+ E G A ++ + + + + T R ++S + +L Sbjct: 564 DLEG--EKATEAGVEFARELGEEILSH-FRAIYLITPFLRYDISVRLLESL 611 >UniRef50_A1AKP7 Methylenetetrahydrofolate reductase n=10 Tax=Desulfuromonadales RepID=A1AKP7_PELPD Length = 615 Score = 169 bits (430), Expect = 8e-41, Method: Composition-based stats. Identities = 51/291 (17%), Positives = 111/291 (38%), Gaps = 32/291 (10%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + ++ E PP+ + + + RL +++ + R ++ I+ + Sbjct: 323 RKLITVELDPPKGLDCSRIIEGC-RRLKRAGVDAINLAENPLARPRMGNIALGSLIQQQV 381 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK------PEMYASDL 135 G+ H+T D +++ GIR ++A+ GD ++++ L Sbjct: 382 GIPVIIHVTGRDRNLIGMQSDLMGASLLGIRSVLAVTGDPATMGDHAGATSVFDLHSLTL 441 Query: 136 VTLLKEVA--------------DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAI 181 + LL ++ F I A +P A+ L++KV GA A Sbjct: 442 IKLLADLNRGVNAMGNPIGGGAGFTIGAA----FNPNARDMAGQASRLRKKVANGAMFAQ 497 Query: 182 TQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFD 240 TQ +D + + + ++A + +IPGI+P+ + + A ++ + IP + Sbjct: 498 TQPIYDAGLFFQALE--LTADCAIPLIPGIMPLVSQRNADYLHNEVPGISIPETVLARMC 555 Query: 241 GLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMSYAICHTL 290 GL+ E G IA + + S ++ + E++ + + Sbjct: 556 GLE--KEAGVAEGLAIAREFI-DASFHSSGGYYLMPPFGKVELALDLIEYI 603 >UniRef50_C4Z117 Methylenetetrahydrofolate reductase n=1 Tax=Eubacterium eligens ATCC 27750 RepID=C4Z117_EUBE2 Length = 595 Score = 167 bits (423), Expect = 5e-40, Method: Composition-based stats. Identities = 54/279 (19%), Positives = 113/279 (40%), Gaps = 16/279 (5%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 +G+ ++ E PP + ++ + ++ + ++ + R + + + + Sbjct: 317 EGRKLIAVELAPPLGID-DEKIMDAAFLMKESGVDVLTFPDSPSGRTRADSILMAEKVSR 375 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG---SGKPEMYASDLV 136 TG+ PH+ C D +R+ N I + + + GD P + ++ D V Sbjct: 376 ETGMCVMPHICCRDKNAIAMRSQLLGAHINDINNFLVITGDPIPSVVRASVKSVFNFDSV 435 Query: 137 TLLKEVADFDIS-VAAYP-----EVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES 190 L+ ++D + A P ++ + + +L +K+K++AGA +TQ F E Sbjct: 436 GLMNIISDMNQEQFAGKPVIYGGAINQGRVNFKVELERVKKKMEAGATFFMTQPVFSDED 495 Query: 191 YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDDDAETR 249 R R G I+ GI+P + + A +MT + + + + D E Sbjct: 496 IDRLRQIKEQTG--ARILCGIMPFVSLRNATFMKNEMTGINVTDEILSRYRA-DMSKEEG 552 Query: 250 KLVGANIAMDMVKILSREGVKDFHF-YTLNRAEMSYAIC 287 + G IA +++ + V ++F + NR M I Sbjct: 553 EETGIQIAREIIAKTTDF-VDGYYFSFPFNRVHMLKKII 590 >UniRef50_B1HTR8 Methylenetetrahydrofolate reductase n=95 Tax=Bacilli RepID=B1HTR8_LYSSC Length = 647 Score = 166 bits (421), Expect = 7e-40, Method: Composition-based stats. Identities = 53/295 (17%), Positives = 120/295 (40%), Gaps = 30/295 (10%) Query: 18 EVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGI 77 +V+ + +V E PR E+E L + +L V + + + R ++ + Sbjct: 347 KVKRERSVIVELDTPRHLEIEGFLEGA-KQLYEAGADVVMMADNSLASPRISNIAMGALL 405 Query: 78 KDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMY 131 K G+ H+TC D L++ GI ++A+ GD P ++ Sbjct: 406 KSTNGVRPLTHITCRDRNLIGLQSHLMGLNALGIHDVLAVTGDPTKVGDFPGATSVYDVS 465 Query: 132 ASDLVTLLKEVA--------------DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGA 177 + +L+ L+K++ +F ++ A +P + + L++K++ GA Sbjct: 466 SMELIQLIKQLNEGVSFSGKPLRKKANFSVAAA----FNPNVRVLDRAVARLEKKIEHGA 521 Query: 178 NRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMA 236 + I+Q + E + + + + I GI+PV+++K A+ ++ +++ Sbjct: 522 DYFISQPVYTKEKMIEIYE--ATKHLQAPIYIGIMPVTSYKSAEFLHHEVPGIKLSEDAL 579 Query: 237 QMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTL 290 +D E L G IA ++V ++ + + T R +++ + + Sbjct: 580 ARMKACGEDKERATLEGIAIAKELV-EVAAQYFNGIYLITPFLRYDVTLELMKYI 633 >UniRef50_B9DIA5 Methylenetetrahydrofolate reductase n=10 Tax=Staphylococcus RepID=B9DIA5_STACT Length = 613 Score = 166 bits (421), Expect = 8e-40, Method: Composition-based stats. Identities = 56/293 (19%), Positives = 119/293 (40%), Gaps = 29/293 (9%) Query: 5 HASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANS 64 H S + +V+ V E P+ + + + ++ +L +++ + + Sbjct: 302 HPSIPVQKDNLTTKVKSGPTVIVELDTPKHLDTTK-FFVNVTKLDKANVDAITLADNSLA 360 Query: 65 GERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL--- 121 R + IK +E H+TC D L++ GI I+A+ GD Sbjct: 361 TVRVSNIAAASIIKQNYNIEPLVHITCRDRNLIGLQSHLLGLSLLGINEILAITGDPSKV 420 Query: 122 ---PPGSGKPEMYASDLVTL--------------LKEVADFDISVAAYPEVHPEAKSAQA 164 P + ++ + L L LK +F+I+ A +P + +A Sbjct: 421 GHLPGANNVYDVNSKGLTELAVRFNQGLNIDGGALKTTTNFNIAGA----FNPNVRKMEA 476 Query: 165 DLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF- 223 + L +K+D+G N ITQ + VE ++ +A +D GI+P+++++ A+ Sbjct: 477 AVRRLDKKLDSGMNYFITQPVYTVEKIQEIAEK--TAHLDSPFFIGIMPITSYRNAQFLH 534 Query: 224 ADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT 276 ++ + +P + + F+ + DD + K + I +V +++ + T Sbjct: 535 NEVPGITLPEDVLEQFEAVKDDKQKTKELSLRICRKLVDEVTKH-FNGLYLIT 586 >UniRef50_C6D4G9 Methylenetetrahydrofolate reductase n=12 Tax=cellular organisms RepID=C6D4G9_PAESJ Length = 632 Score = 164 bits (416), Expect = 3e-39, Method: Composition-based stats. Identities = 45/268 (16%), Positives = 109/268 (40%), Gaps = 25/268 (9%) Query: 27 FEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEAA 86 E PPR ++ + + + +++ + + R ++ +K+R GL Sbjct: 348 VELDPPRDLDITK-FMAGAAAIKACGADAITMADNSLAVTRMSNLALAALVKERIGLRPL 406 Query: 87 PHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS------DLVTLLK 140 H+ C D ++ GI H++A+ GD P+ + +++ + K Sbjct: 407 VHIACRDRNLIGTQSHLMGLDALGIDHVLAVTGDPARFGDLPDSSSVYDLTSFEMIRMTK 466 Query: 141 EVADFDISVAAYP-----------EVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVE 189 ++ D I+ + P +P K + L++K+ +GA+ +TQ +D Sbjct: 467 QLND-GIAFSGKPLKQKAKFVVGAAFNPNVKHLDKAVQRLEKKIASGADYIMTQPVYDPV 525 Query: 190 SYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDDDAET 248 + + + + V + GI+P+++ + A+ ++ +++ + + GL+ Sbjct: 526 LIEKIAE--ATKHLPVPVFIGIMPLASGRNAEYLHNEVPGIQLSDEVRKRMAGLEG--AE 581 Query: 249 RKLVGANIAMDMVKILSREGVKDFHFYT 276 + G I+ +++ R K +F T Sbjct: 582 GRAEGVRISRELLDTAIRH-FKGIYFMT 608 >UniRef50_O06745 5,10-methylenetetrahydrofolate reductase n=78 Tax=Bacillus RepID=YITJ_BACSU Length = 612 Score = 164 bits (415), Expect = 4e-39, Method: Composition-based stats. Identities = 46/310 (14%), Positives = 121/310 (39%), Gaps = 31/310 (10%) Query: 4 FHASQRDALNQSLAEVQGQI-NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGA 62 F + + L E+ + ++ E PP+ ++ L +++ + Sbjct: 298 FISVHHERTEPGLDEIAAKKRSIIVELDPPKKLS-FDKFLSAAAELKEAGIDALTLADNS 356 Query: 63 NSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL- 121 + R + +K + + + H+TC D L++ G+ ++A+ GD Sbjct: 357 LATPRISNVACGALVKQQLDMRSLVHITCRDRNIIGLQSHLMGLDTLGLNDVLAITGDPS 416 Query: 122 -----PPGSGKPEMYASDLVTLLKEVA--------------DFDISVAAYPEVHPEAKSA 162 P + ++ + DL+ L+K+ +F ++ A +P + Sbjct: 417 KIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSGKPLGKKTNFSVAAA----FNPNVRHL 472 Query: 163 QADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKK 222 + L++K+D GA+ ++Q + + + + + I GI+P+++ + A+ Sbjct: 473 DKAVKRLEKKIDCGADYFVSQPVYSEQQLVDI--HNETKHLKTPIYIGIMPLTSSRNAEF 530 Query: 223 F-ADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRA 280 ++ +++ + + +D E +K G IA ++ + E + T R+ Sbjct: 531 IHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIARSLL-DTACELFNGIYLITPFLRS 589 Query: 281 EMSYAICHTL 290 +++ + + Sbjct: 590 DLTAELTSYI 599 >UniRef50_C5RGW2 Methylenetetrahydrofolate reductase n=1 Tax=Clostridium cellulovorans 743B RepID=C5RGW2_CLOCL Length = 609 Score = 164 bits (415), Expect = 4e-39, Method: Composition-based stats. Identities = 49/287 (17%), Positives = 120/287 (41%), Gaps = 28/287 (9%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 +G+ ++ E PP +E++ + + RL +++ + R + + +K Sbjct: 327 RGEKIIAVELDPPINTEIDFFISGA-KRLKGQGIDAITIADCPIARARVDSSLLACKLKR 385 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM------YAS 133 + A PH+TC D + + + GI +++ + GD P + + E+ +S Sbjct: 386 ELDITAIPHMTCRDRNINATKALLLGLNVEGINNVLVVTGDPIPSADREEIKGVFSFNSS 445 Query: 134 DLVTLLKEVAD------FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFD 187 L + ++E+ + F++ A ++ ++ +L ++K+D G +TQ Sbjct: 446 ILSSYIRELNETTFSSPFNVCGA----LNLNVRNFSNELEKAQKKIDNGITMFLTQPVLT 501 Query: 188 VESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD-MTNVRIPAWMAQMFDGLDDDA 246 E+ + ++ +I+ GI+PV +++ A + ++ + + + + + + + Sbjct: 502 EEAMENL--KLARKKLNAKILGGIIPVVSYRNACFMNNEISGINVSEEIIERYKDVSKEE 559 Query: 247 ETRK--LVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTL 290 TR + IA +M V F+ T R ++ I + Sbjct: 560 ATRLAVEISTGIATEM-----SSYVDGFYIITPFKRIDIVSEIVSNI 601 >UniRef50_A8SPV0 Methylenetetrahydrofolate reductase n=2 Tax=Clostridiales RepID=A8SPV0_9FIRM Length = 606 Score = 162 bits (411), Expect = 1e-38, Method: Composition-based stats. Identities = 59/285 (20%), Positives = 111/285 (38%), Gaps = 16/285 (5%) Query: 15 SLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSII 74 ++ G ++ E PP +Q L ++ L V+ + R + + Sbjct: 327 AVKNAGGHKLIAVELAPP-VDVNDQKLLDAAHILKQSHVDVVTFPDSPSGRTRADSILMA 385 Query: 75 KGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP---GSGKPEMY 131 + + TGL PHL C D +R NGI+ + + GD P ++ Sbjct: 386 EKVHKETGLRVMPHLCCRDKNAIAIRGSVLGAQLNGIKDFLVITGDPVPVMFRQTTRSVF 445 Query: 132 ASDLVTLLKEVADFDISV-----AAY-PEVHPEAKSAQADLLNLKRKVDAGANRAITQFF 185 D V ++K + + V Y ++ + + ++ +KRK++AGA ++Q Sbjct: 446 NFDSVGMMKLLQTMNEEVFIGDKITYGGAINQNRINTKFEIDRIKRKLEAGAEFFLSQPV 505 Query: 186 FDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDD 244 F E RD G I+ GI+P+ + + A +MT + IP + + + Sbjct: 506 FSREQAQILRDMKAETGAT--ILVGIMPLVSRRNALFMKNEMTGIEIPDEIIERYGENAT 563 Query: 245 DAETRKLVGANIAMDMVKILSREGVKDFHF-YTLNRAEMSYAICH 288 E + G IA + + + + ++F + NR M I Sbjct: 564 RQEG-EDCGIQIARE-ILDYTADFADGYYFSFPFNRVHMLAHIVD 606 >UniRef50_A9BD12 Methylenetetrahydrofolate reductase n=2 Tax=Prochlorococcus marinus RepID=A9BD12_PROM4 Length = 309 Score = 161 bits (407), Expect = 3e-38, Method: Composition-based stats. Identities = 59/289 (20%), Positives = 106/289 (36%), Gaps = 29/289 (10%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 ++ E PPR + + +LS + ++VT G+ + R + ++ K + L Sbjct: 27 AITAEIMPPRGGDPSHAI-AMASKLSD-RVHALNVTDGSRAIMRMSSLAVCKLLL-EANL 83 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASDLVTLLK 140 E + C D L+ GI++++ L GD +P ++ + V LLK Sbjct: 84 EPVLQIACRDKNRIGLQAEILGAHALGIKNVLCLTGDPVKAGDQPNARPVHDFESVQLLK 143 Query: 141 EVADFDIS---VAAY-PEV----------HPEAKSAQADLLNLKRKVDAGANRAITQFFF 186 +VA + V P P K+ + L L+RK AGA TQ Sbjct: 144 QVAALNRGEDPVQGQLPNGRTALFAGAAADPNCKNLNSLLKRLERKKLAGAQFLQTQMVM 203 Query: 187 DVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD-MTNVRIPAWMAQMFDGLDDD 245 + RF + ++ ++ G+ + + K A + IP + D + Sbjct: 204 NSRVLERFSKEI-ADPLEFPVLAGVFLLKSAKNAAFINKVVPGACIPNSILARLDNAHEP 262 Query: 246 AETRKLVGANIAMDMVKILSREGV-KDFHFYTLNRAEMSYAICHTLGVR 293 + G IA + VK G+ K H + + I V+ Sbjct: 263 IKE----GITIAAEQVKSFL--GITKGVHIMAIRAEHLIPQILDQANVK 305 >UniRef50_A3EWD2 Methylenetetrahydrofolate reductase n=2 Tax=Leptospirillum sp. Group II RepID=A3EWD2_9BACT Length = 289 Score = 160 bits (405), Expect = 6e-38, Method: Composition-based stats. Identities = 61/303 (20%), Positives = 106/303 (34%), Gaps = 44/303 (14%) Query: 9 RDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLK--PKFVSVTYGANSGE 66 R+ALN + V+ E PP+ + + +DRL+ LK ++VT Sbjct: 4 REALNAR------EFLVTAECSPPKGT----RIDGLLDRLTPLKNRIHGINVTDNQTGVM 53 Query: 67 RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG 126 R ++ +K GL+ +T D +++ + G+ ++ L GD P Sbjct: 54 RMCPMAMGLHLKG-IGLDPIIQITLRDRNRLAIQSDLLGMSSLGLSQVLCLTGDPPKLGD 112 Query: 127 KPEMYAS------DLVTLL--------------KEVADFDISVAAYPEVHPEAKSAQADL 166 PE +L+ + D A PE + + Sbjct: 113 HPEAKPVFDIPTQELIRAITLLNGGTDLSGKDLNGKTDILPGAACSPEG-----DQETEF 167 Query: 167 LNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD- 225 + K DAGA TQ F E F ++ V +I GI+ + + K A+ D Sbjct: 168 RKFEEKFDAGARFFQTQAVFSPEKMEEFMR--FASPFSVPVIAGIILLKSAKMARYLNDH 225 Query: 226 MTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYA 285 + + +P + + D G IA + ++ + R V H T+ E Sbjct: 226 VPGITVPPPLIERLDKC--PPGQALESGIAIAAETIRAI-RPLVHGVHIMTVGAEETIPR 282 Query: 286 ICH 288 I Sbjct: 283 ILD 285 >UniRef50_B8CZI6 Methylenetetrahydrofolate reductase n=1 Tax=Halothermothrix orenii H 168 RepID=B8CZI6_HALOH Length = 309 Score = 159 bits (403), Expect = 1e-37, Method: Composition-based stats. Identities = 56/296 (18%), Positives = 107/296 (36%), Gaps = 41/296 (13%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + V+ E PPR E + + LS ++ T + + ++ +K++ Sbjct: 19 EFIVTAELDPPRGVNTEDVVEK-VKYLSDY-VDAINFTDSPMARMKMNPVALTHHLKNKF 76 Query: 82 GLEA--APHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASD-- 134 + HLT D L++ G+++ + L GD P P ++ D Sbjct: 77 NFKVDFICHLTGRDRNLIGLQSELLGGALLGVKNYLFLTGDKPEYGDHPSSTGVFDCDGT 136 Query: 135 -LVTLLKEVA--------------DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANR 179 LV L ++ D I P + ++ LK ++ +GA Sbjct: 137 ALVKLANQLNGGRDYAGNPLNGPLDITIGAGINPGGN-----LTVEIEKLKSRIGSGARF 191 Query: 180 AITQFFFDVESYLRFRDRCVSA----GIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAW 234 TQ +D + F +R + + I+ GI+P+ N+K A ++ V IPA Sbjct: 192 IQTQIVYDPGVVINFMERIKTIEALWPVKPRILFGIMPLKNYKMATYIHENVPGVDIPAP 251 Query: 235 MAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + + D+ G +A + V + V H + R E+ + + Sbjct: 252 VMKAIKKGDE------RTGIKLAKEFVLNIKDY-VDGIHIMPMGRMEVVSELVDAI 300 >UniRef50_Q5TWY6 Methylenetetrahydrofolate reductase n=1 Tax=Anopheles gambiae RepID=Q5TWY6_ANOGA Length = 320 Score = 158 bits (401), Expect = 2e-37, Method: Composition-based stats. Identities = 69/310 (22%), Positives = 132/310 (42%), Gaps = 37/310 (11%) Query: 7 SQRDALNQ--SLAEVQGQINV--SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY-- 60 S LN+ + + G + V S E + L RL+ +P F ++ + Sbjct: 17 SLHTKLNRIFNSSTTSGPVPVHYSIEIA-AKDDFDIDQL----KRLTP-QPVFCALPWIS 70 Query: 61 -----GANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIV 115 A+ R T + +++ +++C + T ++ + R GIR++ Sbjct: 71 DDNLRYADDFLRSPTLQLTARLREN-QYTVLNNVSCYNITEQQVDQLLR---ATGIRNLF 126 Query: 116 ALRGDLPPGSGKPEMYASDLVTLLKE-------VADFDISVAAYPEVHPEAKSAQADLLN 168 +RGD + + A LV L++ F I+V YP H ++ S +L Sbjct: 127 VIRGDTVSPGQQFQNSA-GLVQHLRKWQEQQPNHRQFTIAVGGYPYGHYQSSSQTVELHY 185 Query: 169 LKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTN 228 L+ K+ GA+ +TQ +D S+LR+RDRC AGI + IIPGI +++ + ++T Sbjct: 186 LRAKISQGADFLLTQTLYDAPSFLRYRDRCREAGITIPIIPGIYVPHSYRHLQALLNLTR 245 Query: 229 VRIPAWMAQMFDGLDDD-AETRKLVGANIAMDMVKILS-------REGVKDFHFYTLNRA 280 + + + F+ +D + + + +V+ L + +K HF+T N+ Sbjct: 246 IELGPTVRDAFEAHANDAPDQFQAFMVEYFVGVVRELLQMNATTSSDPIKLVHFFTFNKF 305 Query: 281 EMSYAICHTL 290 + + L Sbjct: 306 HLLQEVLGKL 315 >UniRef50_Q39WH6 Methylenetetrahydrofolate reductase n=4 Tax=Geobacter RepID=Q39WH6_GEOMG Length = 299 Score = 158 bits (399), Expect = 3e-37, Method: Composition-based stats. Identities = 59/288 (20%), Positives = 103/288 (35%), Gaps = 27/288 (9%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 + ++ E PP+ + + L L ++VT + R + + Sbjct: 17 SNRFVITAEVCPPKGCDCGE-FMEKARNLKGL-VDAINVTDNQGANVRISPLAPAALLTR 74 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK---PEMYASDLV 136 G+E LTC D L++ G+ +I++L GD ++ D V Sbjct: 75 E-GIEPILQLTCRDRNRMALQSELLAAAALGVTNILSLSGDYISFGDHAGAKPVFDLDSV 133 Query: 137 TLLKEVADFDIS--VAAYP-EVHPEAKSA----------QADLLNLKRKVDAGANRAITQ 183 LL+ +A + + P E P + L L +KV AGA TQ Sbjct: 134 QLLQTIAALNAGRDFSGAPLEGAPSFFAGAAAAPEADPFDLTLPKLAKKVSAGARFFQTQ 193 Query: 184 FFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNVRIPAWMAQMFDGL 242 F + RF + G V+II GI+ + + A+ ++ +++P + + Sbjct: 194 AVFSPDRLARFSEAVRPLG--VKIIAGIILLKSAGMARYITKNIPGLKVPPEIVAELEAA 251 Query: 243 DDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 E VG IA + +R H + R E+ I L Sbjct: 252 GRPLE----VGVAIARRLA-TAARPFCDGVHIMAMGREELVPNIVAGL 294 >UniRef50_C8WWX3 Methylenetetrahydrofolate reductase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WWX3_ALIAD Length = 637 Score = 158 bits (399), Expect = 3e-37, Method: Composition-based stats. Identities = 56/293 (19%), Positives = 112/293 (38%), Gaps = 33/293 (11%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 + + + E PP+ + L+ +++ + R ++ +K Sbjct: 341 REKKAIVVELDPPK-HLSIARFLEGAEALAGAGADLITMADNSLGSVRVSNMALASLLKQ 399 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL------PPGSGKPEMYAS 133 R G+E H+TC D ++ GIR+++ + GD P + ++ + Sbjct: 400 R-GIEPLVHVTCRDRNLIGQQSHLMGLAVLGIRNVLLVTGDPSRYGELPGATSVYDVSSM 458 Query: 134 DLVTLLKEVAD--------------FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANR 179 DL +++ + + F I A P VH + + + L+RKV+AGA+ Sbjct: 459 DLTKMVRRLNEGIGFSGQPLKQPSRFVIGTAFNPHVH----NFRKAVERLRRKVEAGADF 514 Query: 180 AITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQM 238 +TQ FD + G V + GI+P+++ + A+ + +R+ + Sbjct: 515 VMTQPVFDPNLMAAIAEATRDLG--VPVFVGIMPLTSARNAEFLHHQVPGIRLSEQALRR 572 Query: 239 FDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTL 290 E VG IA ++V++ R + T R EM+ + Sbjct: 573 MQEAA--PEEAPAVGEAIARELVEVAIRL-FPGIYLVTPFLRYEMTVRLTEYA 622 >UniRef50_C0EVI7 Methylenetetrahydrofolate reductase n=1 Tax=Eubacterium hallii DSM 3353 RepID=C0EVI7_9FIRM Length = 638 Score = 157 bits (398), Expect = 4e-37, Method: Composition-based stats. Identities = 50/281 (17%), Positives = 107/281 (38%), Gaps = 16/281 (5%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 G++ + E PP ++ + L + L S K +++ + R + IK Sbjct: 363 GELVCAVELDPPFDTDDTKLLNGA-KALLSTKADIITIADSPLARSRADASLMAAKIKMT 421 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK------PEMYASD 134 TG++ PHL+C D +R+ + +GIR+ + + GD + + + Sbjct: 422 TGMDVMPHLSCRDKNRIAIRSGLLGSYASGIRNYLFVTGDPVAREDREFTKSVFDFNSIR 481 Query: 135 LVTLLKEVAD--FDISVAAY-PEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESY 191 L+ + + F Y ++ S + + +K++AG +TQ +D E Sbjct: 482 LMKFAQSMNQEVFKDDTIFYGGALNQNGASPENIAGRMLKKMEAGCRYFLTQPVYDKEGI 541 Query: 192 LRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDDDAETRK 250 R + +I+ GI+P+ + + A +M + +P + + E + Sbjct: 542 ERLT--FLKERTGAKILIGIMPLVSRRNALFIKNEMPGIHVPDEVVAKYKEGASREEFEE 599 Query: 251 LVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTL 290 + + + F+F T NR + +I + Sbjct: 600 AA--IEISKQIIEMGKGIGAGFYFMTPFNRVSLVKSILEYV 638 >UniRef50_C6HTS1 Methylenetetrahydrofolate reductase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HTS1_9BACT Length = 290 Score = 156 bits (394), Expect = 1e-36, Method: Composition-based stats. Identities = 66/304 (21%), Positives = 109/304 (35%), Gaps = 38/304 (12%) Query: 11 ALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRT 70 Q+LA+ + ++ E PP+ +E + L +L LK + + N R Sbjct: 2 TFRQALAD-RSTFIITAECSPPKGTETSELL----RKLLPLKGRIHGMNITDNQTAVMRM 56 Query: 71 HSIIKGIKDRT-GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE 129 G+ +T GL+ +T D +++ + GI ++ L GD PE Sbjct: 57 SPFAMGLHLKTIGLDPIVQITLRDRNRLAIQSDLLGMSSLGIGQVLCLSGDPATIGDHPE 116 Query: 130 ---MYASDLVTLLKEVA-----------------DFDISVAAYPEVHPEAKSAQADLLNL 169 ++ L++ V D A PE + Sbjct: 117 TKPVFDLSSPELIRAVTLLNGGTDLSGADLTGPTDILPGAATSPEG-----DLSVEKKRF 171 Query: 170 KRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTN 228 + K DAGA TQ FD + RF D G V +I GI+ + + A+ + Sbjct: 172 EEKFDAGARFFQTQVVFDADRMDRFMDFARPFG--VPVICGIILLKSPAMARYLNEKVPG 229 Query: 229 VRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICH 288 +R+P + + + E R L G IA + ++ V H T+ E AI Sbjct: 230 IRVPEPLIARLESV--PREERLLEGVRIAAETIRT-MAPLVNGVHIMTVGAEEQIPAILD 286 Query: 289 -TLG 291 LG Sbjct: 287 LALG 290 >UniRef50_A5N923 Methylenetetrahydrofolate reductase n=2 Tax=Clostridium kluyveri RepID=A5N923_CLOK5 Length = 590 Score = 154 bits (390), Expect = 3e-36, Method: Composition-based stats. Identities = 49/285 (17%), Positives = 115/285 (40%), Gaps = 24/285 (8%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 +G+ ++ E PP +E NS L + +++ + R + + +K Sbjct: 308 KGKKIIAVELDPPIDTE-VDFFLNSARTLKEQEIDAITIADCPIARARVDSSLLACKLKR 366 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYA------S 133 + PH+TC D + + + G+ +++ + GD P + + E+ A + Sbjct: 367 ELDITTIPHMTCRDRNINATKALLLGLNIEGVNNVLVVTGDPIPSAERDEVKAMFSFNSA 426 Query: 134 DLVTLLKEVAD------FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFD 187 L + + D F+I A ++ +++ +L K K++ G +TQ Sbjct: 427 ILANYITNLNDTIFSSPFNICGA----LNVNSRNFNTELKRAKTKIENGIAVFLTQPILT 482 Query: 188 VESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD-MTNVRIPAWMAQMFDGLDDDA 246 E+ + + I+ GI+PV +++ A + ++ +R+ + + + + Sbjct: 483 EEALENL--KLARRELTARILGGIIPVVSYRNACFMNNEISGIRVSEEIIKQYKDVSK-E 539 Query: 247 ETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTL 290 E KL I+ D+ + + V ++ T R ++ I + + Sbjct: 540 EAVKLA-VKISTDIAEQIYPY-VDGYYLITPFKRIDIISEIINNI 582 >UniRef50_Q8DUN2 Methylenetetrahydrofolate reductase n=12 Tax=Streptococcus RepID=Q8DUN2_STRMU Length = 618 Score = 154 bits (389), Expect = 5e-36, Method: Composition-based stats. Identities = 52/302 (17%), Positives = 113/302 (37%), Gaps = 30/302 (9%) Query: 16 LAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIK 75 + +V+ I + E PP+T + + L +++ + + R S+ Sbjct: 318 VDKVKKGITIIAEIDPPKTLA-VDKFVDGVKALDEKGIAAITLADNSLARTRICNLSMAS 376 Query: 76 GIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL------PPGSGKPE 129 +KD HL+C D L++ G HI+A+ GD P + + Sbjct: 377 MLKDEIATPFLLHLSCRDHNMIGLQSRLLGMDLLGFDHILAITGDPSKIGDFPGATSVYD 436 Query: 130 MYASDLVTLLKEVA--------------DFDISVAAYPEVHPEAKSAQADLLNLKRKVDA 175 + L++L+K++ F ++ A +P K+ +++KV A Sbjct: 437 ATSFKLLSLIKQLNQGHGYSGASLKKATHFTVAAA----FNPNVKNLSRTGRLIEKKVAA 492 Query: 176 GANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAW 234 GA+ ITQ F + V+ + GI+P++++ A ++ + + Sbjct: 493 GADYFITQPVFSETVIQELSE--VTKPYEQPFFVGIMPITSYNNAVFLHNEVPGISLSES 550 Query: 235 MAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTLGVR 293 + + DD ET + V + ++ + + T R +++ + + V+ Sbjct: 551 FLAKLEAVKDDKETCQKVALAESKKLIDAILAH-FNGIYLITPFLRYDLTVELIDYIQVK 609 Query: 294 PG 295 Sbjct: 610 TA 611 >UniRef50_B8I637 Methylenetetrahydrofolate reductase n=2 Tax=Clostridium RepID=B8I637_CLOCE Length = 615 Score = 153 bits (388), Expect = 6e-36, Method: Composition-based stats. Identities = 51/282 (18%), Positives = 105/282 (37%), Gaps = 21/282 (7%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + + E PP + E L +++ L +++ + R + + I+ Sbjct: 339 KKPILVEVDPPFDTNWEYMLRDTL-LLKQAGADIITIADSPLAKARAESTIMAAKIQREA 397 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG------SGKPEMYASDL 135 + PH+TC D ++ GIR+++ + GD G +S+L Sbjct: 398 VIPVMPHITCRDKNLLGIKASLLGVHIEGIRNVLVITGDPIANIERSRIKGVFSFNSSNL 457 Query: 136 VTLLKEVAD--FD---ISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES 190 +K + F I +A ++ A + A+L K++ G + +TQ + + Sbjct: 458 ANYIKSLNSNVFCGQEIKIAG--ALNVNAVNFSAELKKAFTKIENGISCLLTQAIYTKSA 515 Query: 191 YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDDDAETR 249 + + V I G +P+ +K A ++ + I + F D E Sbjct: 516 VDNLLKAVET--LKVPIFAGFMPIVGYKNALFIDNEVPGIDIDNETIEKFR--DKSREES 571 Query: 250 KLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTL 290 + +G I MD++K + V + T L R + + + Sbjct: 572 EKLGMEITMDILKEIYPH-VSGIYLMTPLKRTNVICELIKKI 612 >UniRef50_B9JGE7 Methylenetetrahydrofolate reductase n=3 Tax=Rhizobiales RepID=B9JGE7_AGRRK Length = 368 Score = 152 bits (384), Expect = 1e-35, Method: Composition-based stats. Identities = 57/297 (19%), Positives = 115/297 (38%), Gaps = 28/297 (9%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 +G+ V+ E PP ++ E ++ S ++ + + + I + Sbjct: 33 RGEFAVTAELNPPDSANPED-VYERAAIFSGW-VDGINAVDASGANCHMSSVGICA-LLT 89 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS-DL--- 135 R G + C D ++ G+ +I+ L GD +P DL Sbjct: 90 RMGYAPIMQIACRDKNRIAIQGDVLGAAAMGVCNIMCLTGDGVQAGDQPGAKPVFDLDCM 149 Query: 136 -----VTLLKEVADFDIS--------VAAYPEVHPEAKSAQADLLNLKRKVDAGANRAIT 182 V ++++ A F V ++P A L +K++AGA + Sbjct: 150 SLLETVRVMRDNAKFLSGRKLTSPPKVFLGAAINPFAPPYDFRPYRLAKKIEAGAQFVQS 209 Query: 183 QFFFDVESYLRFRDRCVSAGIDVE--IIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMF 239 Q+ +DV + + + G+ + I+ G+ P+++ K A+ +++ V IP + + Sbjct: 210 QYCYDVPMFRDYMKKVRDLGLHEKCFILVGVGPLASAKTARWMRSNVPGVHIPDEIIKRI 269 Query: 240 DGLDDDAETRKLVGANIAMDMVKILSR-EGVKDFHFYTLNRAEMSYAICHTLGVRPG 295 +G +D +K G + +D++ + EGV H + E + H GV G Sbjct: 270 EGAED----QKKEGKQLCIDIINEVKEIEGVSGVHVMAYRQEEYVAEMVHDSGVLKG 322 >UniRef50_A6UAD8 Methylenetetrahydrofolate reductase n=11 Tax=Proteobacteria RepID=A6UAD8_SINMW Length = 367 Score = 149 bits (378), Expect = 7e-35, Method: Composition-based stats. Identities = 59/309 (19%), Positives = 117/309 (37%), Gaps = 34/309 (11%) Query: 7 SQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLK--PKFVSVTYGANS 64 S R L + L +G+ V+ E PP + +R + ++ + + Sbjct: 21 SSRGRLERVLR--RGEFAVTAELNPP----DSANPHDVYERAAIFDGWVDGINAVDASGA 74 Query: 65 GERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG 124 + I + R G + C D ++ G+++I+ L GD Sbjct: 75 NCHMSSVGICA-LLTRMGYAPIMQIACRDRNRIAIQGDVLGASAMGVQNIMCLTGDGVQA 133 Query: 125 SGKPEMYAS-DL--------VTLLKEVADFDIS--------VAAYPEVHPEAKSAQADLL 167 +P DL V ++++ + F V ++P A Sbjct: 134 GDQPGAKPVFDLDCMSLLETVRIMRDNSKFLSGRKLSTPPHVFLGAAINPFAPPYDFRPY 193 Query: 168 NLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVE--IIPGILPVSNFKQAKKF-A 224 L +K++AGA +Q+ FDV + + + G+ + I+ G+ P+++ K A+ + Sbjct: 194 RLAKKIEAGAQFVQSQYCFDVPMFREYMKKVRDLGLHEKCFILVGVGPLASAKTARWIRS 253 Query: 225 DMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSR-EGVKDFHFYTLNRAEMS 283 ++ + IP + + +G D +K G + +D++ + EGV H + E Sbjct: 254 NVPGIHIPDGIIRRLEGAQD----QKKEGKQLCIDVMNEVKEIEGVSGVHVMAYRQEEYV 309 Query: 284 YAICHTLGV 292 I H GV Sbjct: 310 AEIVHESGV 318 >UniRef50_C7LX76 Methylenetetrahydrofolate reductase n=1 Tax=Desulfomicrobium baculatum DSM 4028 RepID=C7LX76_DESBD Length = 599 Score = 149 bits (378), Expect = 8e-35, Method: Composition-based stats. Identities = 50/307 (16%), Positives = 116/307 (37%), Gaps = 34/307 (11%) Query: 8 QRDALNQSLAEVQGQ-INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE 66 + A L+ G+ + E PP+ + + + + + LS+ +++ + Sbjct: 303 TQTAAPTRLSRRLGEGKVILVELDPPKHLD-VEPVLAAAEALSAAGVDAITIAENPLAVP 361 Query: 67 RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS- 125 R + ++ RTG++ H+T D +++ + + +++A+ GD P Sbjct: 362 RLSNIVLAGMVRARTGVDVVVHMTGRDRNLVGMQSTIMGLAASKLHNVLAVTGDPPSAGS 421 Query: 126 -----GKPEMYASDLVTLLKEVA--------------DFDISVAAYPEVHPEAKSAQADL 166 G ++ + +L+ LL +F I A +P ++ + Sbjct: 422 AERVSGVYDLRSLELMELLAGFNQGRNHYGDSMRLPVNFCIGGA----FNPNTRNMALQV 477 Query: 167 LNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-AD 225 +++K+ AGA+ +TQ + I I+ GI+P+++ + A+ + Sbjct: 478 GRMEKKMAAGASYFLTQPVYSRARVDEILAATRH--IKAPIVLGIMPLASSRNAEFLHNE 535 Query: 226 MTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMSY 284 + IP + D + G +IA ++++ + NR M+ Sbjct: 536 FPGIEIPLETRERMARAGDHGQEE---GVDIAWELLEYAWSHFA-GVYIIPPFNRHGMAL 591 Query: 285 AICHTLG 291 + LG Sbjct: 592 ELMRRLG 598 >UniRef50_Q05FX5 Methylenetetrahydrofolate reductase n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FX5_CARRP Length = 239 Score = 148 bits (374), Expect = 2e-34, Method: Composition-based stats. Identities = 63/263 (23%), Positives = 104/263 (39%), Gaps = 30/263 (11%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 N+SFE FP + L I+ L+ KP FVSVT+G + +K I+ + Sbjct: 2 KNISFEIFPCNNIKDLSVL---INYLNKNKPSFVSVTFG-----KINNLKFVKNIQKQIS 53 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASD-LVTLLKE 141 + PHL C + + I + + + GD + +Y L + Sbjct: 54 TKIIPHLIC--DNIFNIINYIIYFIKIKIFNFLIITGDKNKNNSIKYIYFIRFLFGHI-- 109 Query: 142 VADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSA 201 I Y E H +K+ + ++L +K G N ITQFF++ + + + Sbjct: 110 ---IKIITGCYFENHKFSKNFKNEILFHYKKNKIGTNMCITQFFYNFNTIKYYINIIKKT 166 Query: 202 GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMV 261 GI I GI+ N K + ++ + IP W+ + + NI + V Sbjct: 167 GISKNFILGIISKKNIKDILNYTNLCKIDIPIWIIKNYKEF------------NIELFFV 214 Query: 262 KILSREGVKDFHFYTLNRAEMSY 284 K L + K+ HFYT N + Sbjct: 215 KNLKKY--KNLHFYTFNNINLIK 235 >UniRef50_B3TCN7 Methylenetetrahydrofolate reductase n=1 Tax=uncultured marine bacterium HF4000_APKG2098 RepID=B3TCN7_9BACT Length = 298 Score = 146 bits (370), Expect = 7e-34, Method: Composition-based stats. Identities = 59/305 (19%), Positives = 111/305 (36%), Gaps = 28/305 (9%) Query: 8 QRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGER 67 + L++ L + G + E PP S ++TL I L + ++VT + Sbjct: 3 YQSPLHKKLHD--GVFVFTAETTPP-DSSNKETLLKKIKSLKDV-ADAINVTDSPGAKVH 58 Query: 68 DRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK 127 I + ++ LT D L+ G+ +I+ L GD P + Sbjct: 59 MSAL-TAAIILAQNDIDPILQLTVRDRNRLALQGDLVGASALGVHNILCLSGDDPKVGDQ 117 Query: 128 PEMYASD------LVT---LLKEVADFDISVAAYPE-----VHPEAKSA-QADLLNLKRK 172 PE + LV ++++ F A P E S + + + K Sbjct: 118 PETKPAQDIDSTTLVATANMMRKDKKFPSGRAIDPAPKLFIGGAEVPSKGKPNTEKILGK 177 Query: 173 VDAGANRAITQFFFDVESYLRFRDRCVSAGI--DVEIIPGILPVSNFKQAKKFA-DMTNV 229 + G + TQ+ F+ + + AGI + G+ P ++ K AK ++ V Sbjct: 178 IKNGIDFFQTQYVFEAKKLEEYMKVLNDAGILEKTSFLIGLGPFASAKSAKWMNDNLFGV 237 Query: 230 RIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSR-EGVKDFHFYTLNRAEMSYAICH 288 +P + + + D E K V +++++I +GVK H + E+ I Sbjct: 238 DVPDEIIKRLEQAKDQREESKKV----CLELIQIFHEIKGVKGIHLMGHKKEEVIAEIIK 293 Query: 289 TLGVR 293 + Sbjct: 294 ESKIS 298 >UniRef50_UPI0001BCEC92 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein n=1 Tax=Selenomonas noxia ATCC 43541 RepID=UPI0001BCEC92 Length = 597 Score = 144 bits (363), Expect = 5e-33, Method: Composition-based stats. Identities = 49/285 (17%), Positives = 109/285 (38%), Gaps = 17/285 (5%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G ++ E PP T ++ L + L + +++ + R + + Sbjct: 315 SGGKPIAVELDPPETGNADKFLVG-VRELQAAGISAITIADNPIARARMDAAMLAGRVHR 373 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASD----- 134 G+E PH+TC D + +++I G+ +++A+ GD P + + E+ + Sbjct: 374 ELGIEPIPHMTCRDRNLNAIKSILLGLSAEGVHNMIAITGDPIPTAERDEVKSVYQFNSR 433 Query: 135 ----LVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES 190 VT L D + + ++ AK + L ++K++AG TQ E Sbjct: 434 KLASFVTSLGSRGDI-VPFHVFGALNVNAKHFPSQLGLARKKMEAGMTGFFTQPVLS-ER 491 Query: 191 YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNVRIPAWMAQMFDGLDDDAETR 249 I+ GI+PV + + A+ ++ + + + + GL D Sbjct: 492 AKENLQTARDMLPGAFILGGIMPVVSERNARFMESEIVGIHVEERIISAYRGL--DRTAA 549 Query: 250 KLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTLGVR 293 + + +++ + K + + ++ T +R + I + R Sbjct: 550 EELAVRLSLAIAKDI-EPYIDGYYIITPFSRTALIARIVEGIKER 593 >UniRef50_A4TRX0 Methylenetetrahydrofolate reductase n=1 Tax=Yersinia pestis Pestoides F RepID=A4TRX0_YERPP Length = 187 Score = 141 bits (356), Expect = 3e-32, Method: Composition-based stats. Identities = 41/193 (21%), Positives = 77/193 (39%), Gaps = 12/193 (6%) Query: 101 TIARDYWNNGIRHIVALRGDLPP-GSGKPEMYASDLVTLLKEVA-DFDISVAAYPEVHPE 158 I Y N GI +RGD P Y +L+ L++ I + YP+ H E Sbjct: 2 QIIEKYINVGICEFFVIRGDKHVYDQDNPINYGVELIELIRRSHKHIGIKTSLYPDFHKE 61 Query: 159 AKSAQADLLNLKRKVDAGANRAITQFFFDVESY---LRFRDRCVSAGIDVEIIPGILPVS 215 + ++ +RK G N I+Q + + + D+ P I+P+ Sbjct: 62 TTEVKEEIDWNERKYQLGVNEFISQLTLNTNALDFLSHWVDKER------PFTPSIMPLG 115 Query: 216 NFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY 275 NF +KF ++ P W+ + + + E ++ +G I + + + + H + Sbjct: 116 NFSFIEKFTSSNSIDYPLWIKKFANSKSNSNEDKENIGIEIIRFLCREYLNQRER-LHVF 174 Query: 276 TLNRAEMSYAICH 288 TLN+ ++ I Sbjct: 175 TLNKVDVMKKIFQ 187 >UniRef50_B5YA71 Methylenetetrahydrofolate reductase n=2 Tax=Dictyoglomus RepID=B5YA71_DICT6 Length = 288 Score = 141 bits (356), Expect = 3e-32, Method: Composition-based stats. Identities = 58/295 (19%), Positives = 102/295 (34%), Gaps = 37/295 (12%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G+ ++ E PPR ++ + ++ L + V+VT N G R + + + Sbjct: 9 SGKFVITAEVSPPRGVDVSSFIEKTL--LLKDRVDAVNVTDFQNVGVRITSL-VGSYLLL 65 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS---GKPEMYASD-- 134 R G+E +T D + + GIR+++ L GD ++ D Sbjct: 66 REGMEPIFQITARDRNRVAISGELLSAYTLGIRNVLVLTGDYTTTGIAKSAKPVFDLDAT 125 Query: 135 --LV-------------TLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANR 179 LV L + DF + P + P L AGA Sbjct: 126 NILVVAKRLEDGEDFSGKKLNKNPDFFLGAVFNPNLVPLEIEILKLLKK----KKAGAEF 181 Query: 180 AITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKK-FADMTNVRIPAWMAQM 238 TQ FFD+ R R+R G +++II G+ + + + + + ++IP + M Sbjct: 182 FQTQLFFDLSVMERVRERV---GNEIKIIAGVTIFKSIEMLEYMMSSVPGIKIPTEILDM 238 Query: 239 FDGLDDDAETRKLVGANIAMDMVKILSRE-GVKDFHFYTLNRAEMSYAICHTLGV 292 F D K + + L + HF +R + L Sbjct: 239 FRNTKD----IKSLSIEFCAEFCSKLKESKLLDGIHFLA-SRPSDIIKVLDLLNW 288 >UniRef50_B8FJ30 Methylenetetrahydrofolate reductase n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FJ30_DESAA Length = 312 Score = 138 bits (348), Expect = 2e-31, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 114/295 (38%), Gaps = 33/295 (11%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSI-IKGIK 78 GQ V E PP+ ++ N+I R+ FV V + R S+ I Sbjct: 9 AGQFIVLAEMEPPKGVDVTDFTANAI-RVKDQVDAFV-VP--EMNSAVMRMSSLGASLIL 64 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASDL 135 GL + C D L+ G+R+++A+ G+ P + +Y DL Sbjct: 65 QSKGLPTVMQVNCRDRNRLGLQADLLAAGAIGVRNVMAVTGEDPSFGDHHQASAVYDIDL 124 Query: 136 VTLLKEVADF-------DISVAAYPEVH--------PEAKSAQADLLNLKRKVDAGANRA 180 + LLK V + +A P + K+ Q ++ +KRK+DAGA Sbjct: 125 IELLKAVRGMTEGKDMAGVDLAGAPSFYCGSTVNAGVRGKALQLEIDEMKRKMDAGARFF 184 Query: 181 ITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMT-NVRIPAWMAQMF 239 IT F++ F ++ A +V+++P +L + + A+ + +V + + + Sbjct: 185 ITPPVFNMNDLSDFMEKASRA--EVKVLPTVLLLKSVGMARYIDRHSDHVSVGDALIKRI 242 Query: 240 DGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRP 294 D A A IA D ++ G+ TL M + L ++P Sbjct: 243 MSASDKAREC----AQIAADTIQAAKNAGLDGVMIATLGWEHMLPQV---LNLKP 290 >UniRef50_Q64DN7 5-10-methylenetetrahydrofolate reductase n=3 Tax=environmental samples RepID=Q64DN7_9ARCH Length = 306 Score = 125 bits (315), Expect = 2e-27, Method: Composition-based stats. Identities = 56/300 (18%), Positives = 107/300 (35%), Gaps = 29/300 (9%) Query: 10 DALNQSLAEVQ-GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERD 68 + + + E++ G+ + E P + ++ + + L + +VT S Sbjct: 4 EIYSDLMRELREGEYVFTGELEPEKAGDVNEPI-EMARELVGM-VVACNVTDNPQSFAYV 61 Query: 69 RTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP 128 + + I+ TG+E L C D L + G+++I+AL GD P Sbjct: 62 NSMAASYLIQKETGMECVYQLRCSDRNRMALLSDVLGAGALGLKNILALAGDHVSLGDTP 121 Query: 129 E---MYASD---LVTLLKEVADFDISVAAY-----PEVHP------EAKSAQADLLNLKR 171 + ++ D L+ L++ + D + P++H A +A++ +KR Sbjct: 122 DAKPVFDLDSTTLIKLIRTMVDDGKDLGGNEIHNPPKLHVGGAAAPGAAHLKAEVGKVKR 181 Query: 172 KVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD-MTNVR 230 K++AG TQ + + +F D +DV I+ GI P F QA F + V Sbjct: 182 KINAGVEYLQTQVVYYTDVLDKFFDELGK--VDVPILVGIFPARTFGQADFFDKYVAGVD 239 Query: 231 IPAWMAQMFDGLD------DDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSY 284 +P + E V ++ L H + + Sbjct: 240 VPPDYLEAMRATKAIKDKEKKKEEVDRVNIEFFTGFLEHLKGTPAAGCHMMAVGYPRIIP 299 >UniRef50_D0RM84 Methylenetetrahydrofolate reductase n=1 Tax=Phytophthora infestans T30-4 RepID=D0RM84_PHYIN Length = 469 Score = 124 bits (313), Expect = 3e-27, Method: Composition-based stats. Identities = 29/104 (27%), Positives = 50/104 (48%) Query: 192 LRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKL 251 +++ +C AGI + I+PG LP+ N+ KF R+P + D + +D + Sbjct: 2 IQWITQCKDAGISIPILPGYLPIQNYSSFCKFTSWCKTRVPEKVLAALDAIKNDDAAVRR 61 Query: 252 VGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPG 295 G +A++ + L GV HFYT+N A + L ++P Sbjct: 62 YGTQLAVETCQRLLAAGVNSLHFYTMNLAATVTQVLEELQLQPA 105 >UniRef50_C0QIT4 Methylenetetrahydrofolate reductase n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QIT4_DESAH Length = 274 Score = 124 bits (313), Expect = 3e-27, Method: Composition-based stats. Identities = 50/240 (20%), Positives = 88/240 (36%), Gaps = 13/240 (5%) Query: 12 LNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTH 71 + + + ++ E PP + E L + +S L SV + Sbjct: 1 MEKRFMTAKDGFKITVEVVPPAGFDPEPLLEQLVS-ISGLGFDGFSVATNPVAKPCMCAM 59 Query: 72 SIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP--- 128 ++ I+ RTG + H T D L+ GI ++A GD+ + Sbjct: 60 AMCSLIQGRTGKPSILHCTTRDHNRLSLQGQLWGAKALGIDTVLAATGDMVAKKERKITS 119 Query: 129 ---EMYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFF 185 ++ L + + D V + HPE + L++KVDAGA +TQ Sbjct: 120 TVSDLNVFQLAAMAVQSG-MDTGVVF--DSHPEINGFDLAVDRLRKKVDAGAGFVVTQPV 176 Query: 186 FDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNVRIPAWMAQMFDGLDD 244 +D S R + G+ + +I GILP+ K A + + +P + +D Sbjct: 177 YDRASAERI--AVATQGLGIPVILGILPLRTLKHAVFLHDRVAGIAVPESVRSAMALAED 234 >UniRef50_B0TCJ7 Methylenetetrahydrofolate reductase n=6 Tax=Bacteria RepID=B0TCJ7_HELMI Length = 258 Score = 124 bits (311), Expect = 5e-27, Method: Composition-based stats. Identities = 43/167 (25%), Positives = 69/167 (41%), Gaps = 5/167 (2%) Query: 74 IKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS 133 R A PH+ ID PD +A NGI ++ + GD P + +Y + Sbjct: 57 ACTCAKRYFATAIPHIRAIDLNPDAPLQMAEQLQQNGIAEVLIVTGDPPQDMSRK-VYPT 115 Query: 134 DLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLR 193 + +++ + Y + P S + + +KRK+DAGA+ TQ FFD LR Sbjct: 116 TSIDVIRRFKRELPDMKVYAAIDPYRNSLRKEYDYIKRKIDAGADGFFTQPFFD----LR 171 Query: 194 FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFD 240 F + ++ GI PV+ K A + +V PA + Sbjct: 172 FMEIYGEMLEGQQVFWGISPVTTEKSACYWETKNHVLFPADFEPTLE 218 >UniRef50_B9KC45 Methylenetetrahydrofolate reductase n=6 Tax=Thermotogaceae RepID=B9KC45_THENN Length = 281 Score = 122 bits (308), Expect = 9e-27, Method: Composition-based stats. Identities = 49/275 (17%), Positives = 96/275 (34%), Gaps = 39/275 (14%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G+ V E PR + + + ++ +VT R + + + Sbjct: 7 SGKCVV-LEVLTPRGTN-LKKFLDFTEKAWETGIDAFTVTDMPMGRVRMAPWA-VSHLLV 63 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS------ 133 +G E H T +++ GI +++ L GD P P+ + Sbjct: 64 ESGKEVLMHFTRNTRNMIRIQSDLLGCHALGIENLLLLSGDDPSHGDYPQTTSVNDVDIL 123 Query: 134 DLVTLLKEVA--------------DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANR 179 DL+ L K + +F + A P + DL K+K++AG + Sbjct: 124 DLIRLTKLLNEGTDLAGNRMYGKTNFFVGGALNPFS-------EKDLERAKQKIEAGVDF 176 Query: 180 AITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMF 239 +TQ F + + +++ + +I+ I N KQ F+ + + IP + Sbjct: 177 LVTQPLFQRDVAQKIKEK-----LSTKILVSIAFFENAKQMNHFSGVPGIEIPKEI---I 228 Query: 240 DGLDDDAETRKLVGANIAMDMVKILSREGVKDFHF 274 + + E K + V+ +R V F+ Sbjct: 229 ESAEKGDEHVKERSFEAVLRFVEE-TRNIVDGFYI 262 >UniRef50_Q60FX0 Methylenetetrahydrofolate reductase n=1 Tax=Sphingomonas paucimobilis RepID=Q60FX0_PSEPA Length = 288 Score = 122 bits (307), Expect = 1e-26, Method: Composition-based stats. Identities = 65/269 (24%), Positives = 106/269 (39%), Gaps = 33/269 (12%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 S E P + + L N+ + +SVT+ + DR + K I+ G Sbjct: 18 YSLEITP----KDVEALENAAHMIPPG--TLISVTFLPGAEYEDRARA-AKRIQ-ELGFR 69 Query: 85 AAPHLTCIDA-TPDELRTIARDYW-NNGIRHIVALRGDLPPGSGKPEMYASDLVT--LLK 140 PHL+ +LRT ++H+ + GD G E A L+ +LK Sbjct: 70 PVPHLSARRLIDEADLRTYLDMLKGVIDLKHVFVIAGDPNEPLGIYED-ALALIDSGILK 128 Query: 141 EVADFDISVAAYPEVHPE------AKSAQADLLNLKRKVDAGANR-AITQFFFDVESYLR 193 E ++ YPE HP+ AK+ + +LKR+ G + +TQF FD E L Sbjct: 129 EYGIEHCGISGYPEGHPDITDEKLAKAMHDKVASLKRQ---GIDYSIMTQFGFDAEPVLE 185 Query: 194 FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVG 253 + + S GID + G+ ++ K +FA V A + + + L+G Sbjct: 186 WLKQIRSEGIDGPVRIGLAGPASIKTLLRFAARCGVGTSAKVVKKY-----GLSITSLIG 240 Query: 254 AN----IAMDMVKILS-REGVKDFHFYTL 277 + + D+ +L G HFY Sbjct: 241 SAGPDPVIEDLTPVLGPEHGQVHLHFYPF 269 >UniRef50_B6A4H7 Methylenetetrahydrofolate reductase n=2 Tax=Rhizobium leguminosarum RepID=B6A4H7_RHILW Length = 292 Score = 120 bits (302), Expect = 5e-26, Method: Composition-based stats. Identities = 54/219 (24%), Positives = 81/219 (36%), Gaps = 15/219 (6%) Query: 74 IKGIKDRTGLEAAPHLTCID-ATPDELRTIARDY-WNNGIRHIVALRGDLPPGSGKPEMY 131 G PH+ + EL T+ G+RH + L GD +G Sbjct: 63 AAAGLRDAGFVPVPHIVARNIRNRPELDTMLARLSEEAGVRHALVLGGDRDDAAGA-FSS 121 Query: 132 ASDLVT--LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANR-----AITQF 184 A DL+ L + I++A YPE HP A D L KVDA A ++QF Sbjct: 122 ALDLIETGLFQTYGIGRIAIACYPEGHPRIAGAVLDTA-LTAKVDAAARAGLDLLLVSQF 180 Query: 185 FFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIP-AWMAQMFDGLD 243 FD + L F R G+ V + GI + + K+A V + + + Sbjct: 181 LFDQKPLLSFARRLRERGVTVPLRVGIAGPAGRTKLLKYALRCGVGASLRALRERSEIAR 240 Query: 244 D--DAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRA 280 + ET + + +IA G+ HF+T Sbjct: 241 NVLSGETPEELLIDIAAAQTAE-PDLGISGVHFFTFGDP 278 >UniRef50_Q7M8S8 Methylenetetrahydrofolate reductase n=1 Tax=Wolinella succinogenes RepID=Q7M8S8_WOLSU Length = 318 Score = 119 bits (298), Expect = 2e-25, Method: Composition-based stats. Identities = 49/304 (16%), Positives = 108/304 (35%), Gaps = 26/304 (8%) Query: 8 QRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGER 67 + + + ++Q ++ E P + + + + + T + R Sbjct: 12 TKTMIETLIHKLQKDHFLTLEVAPHASPTLTPLIHSIQSVGLEKRVDGFVCTDSPLAKLR 71 Query: 68 DRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL------ 121 + ++ L+ D L+ +R I+AL GD Sbjct: 72 HSSILATIKLQQSLQKPVICTLSMRDRNSLALQGELMGANEFDVRAILALTGDAIRLGDQ 131 Query: 122 PPGSGKPEMYASDLVTLLKEVADFDISVAAYPEVHP------------EAKSAQADLLNL 169 P G E ++ L+ +++ I + P P ++S ++ L Sbjct: 132 PQAKGVFEGKSTLLLEIIQSFNR-GIDLQGQPLKSPLRPLYPLAVINSYSQSPESLKKRL 190 Query: 170 KRKVDAGANRAITQFFFDVE---SYLRFR-DRCVSAGIDVEIIPGILPVSNFKQAKKF-A 224 ++K++AGA +TQ +D+E + L + + G E++ G PV +++ A + Sbjct: 191 RQKIEAGAIGIVTQPIYDLEVAKTLLGWVHEINQELGTFSELVLGYFPVVSYRTAHFLYS 250 Query: 225 DMTNVRIPAWMAQMFDGLDD-DAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMS 283 + V IP + + E + VG ++ ++ L HF + N +++ Sbjct: 251 KLPGVYIPNEWLSQLEAASKINPEEERRVGLELSRNIWLGLWDFH-PKIHFMSANNTKLA 309 Query: 284 YAIC 287 I Sbjct: 310 SEIL 313 >UniRef50_A9G9E1 Methylenetetrahydrofolate reductase n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9G9E1_SORC5 Length = 303 Score = 118 bits (297), Expect = 2e-25, Method: Composition-based stats. Identities = 57/308 (18%), Positives = 104/308 (33%), Gaps = 30/308 (9%) Query: 7 SQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE 66 + + + L+E Q VS E PPR ++E+ L ++ ++ V + S Sbjct: 2 VTKSKMERLLSERQ--FLVSAELTPPRHYDLEKLLKHA-RNMAGC-VDVVQINDHLLSQA 57 Query: 67 RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRG------- 119 R ++ +K GLE + L+ G+ +I+ L G Sbjct: 58 RCANMAVGHFVKQE-GLEPVLQFSLRHKNKIALQGDLLGMAALGLSNIIVLGGYPCAIGS 116 Query: 120 --DLPPGSGKPEMYASDLVTLLKEVADFDIS--VAAYPEVHPEAKSA-------QADLLN 168 D S A +L L V+ P H + Sbjct: 117 DPDAKEVSDVDSYAAIELTRRLTREGKLFNGDVVSPAPYFHVGTIDFPCAEQAIAGAMDR 176 Query: 169 LKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGI--DVEIIPGILPVSNFKQAKKFADM 226 L K+DAGA+ Q F++ S R+ V G+ I I P + + + Sbjct: 177 LAAKIDAGASFIQVQAVFELASMRRWMAAVVERGLHERAHFIAAIFPFAGVDRLSFLQKV 236 Query: 227 TNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSR-EGVKDFHFYTLNRAEMSYA 285 + +P + + L DAE I +++++ L G+ H ++ + Sbjct: 237 PGLVVPDHLIERV-RLSGDAEGESY---RITLELIRGLRDIPGLSGIHMRSIGAEDWVPR 292 Query: 286 ICHTLGVR 293 + G+R Sbjct: 293 LVDEAGLR 300 >UniRef50_C0QE80 Methylenetetrahydrofolate reductase n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QE80_DESAH Length = 505 Score = 118 bits (296), Expect = 3e-25, Method: Composition-based stats. Identities = 52/275 (18%), Positives = 91/275 (33%), Gaps = 26/275 (9%) Query: 22 QINVSFEFFPPRTSEM--EQTLWN-SIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 ++ E P R S TL + D S + VS+T + I Sbjct: 14 NFVITIELVPGRESFGRNTDTLIGIAKDAFSDGRVSAVSITDNPGGNPSLSPDVLGYEI- 72 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP----PGSGKPEMYASD 134 R GL+ H TC D + + A G+++I+ L GD G G P ++ D Sbjct: 73 FRHGLDVIVHFTCRDMNRVGMESRALQLARMGMKNILCLTGDYSGKGFGGRGAP-VFDLD 131 Query: 135 LVTLLKEVAD-------------FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAI 181 V L + V F P +++ A L K+DAGA+ AI Sbjct: 132 SVLLTRMVKGLSNRMMTSGDPDPFFSGCGVSPFKTLKSECL-AQYKKLDMKIDAGASFAI 190 Query: 182 TQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD--MTNVRIPAWMAQMF 239 TQ +D+ + + ++ + + + K A+ + + + + Sbjct: 191 TQLGYDINKFNELIRYHNEKNAHIPVMASVF-LLSPKAARAMNKHRVPGAHVSDALYEKV 249 Query: 240 DGLDDDAETRKLVGANIAMDMVKILSREGVKDFHF 274 + + + IL G + H Sbjct: 250 TQEWKIPKEGLNAAIERSARLGAILKGIGFRGIHI 284 >UniRef50_B9L912 Methylenetetrahydrofolate reductase n=1 Tax=Nautilia profundicola AmH RepID=B9L912_NAUPA Length = 298 Score = 118 bits (296), Expect = 3e-25, Method: Composition-based stats. Identities = 55/297 (18%), Positives = 112/297 (37%), Gaps = 27/297 (9%) Query: 15 SLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSII 74 L E ++ E PP+ ++ + + S T S + + Sbjct: 1 MLKEKLKDKYITLETTPPKLPTVDLMIEKIEKSEAYKYIDGFSTTDCPLSKLKYNSIIAA 60 Query: 75 KGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASD 134 ++++ ++ D L++ + G+ HI+AL GD S +P+ A Sbjct: 61 YKLQEKFKKPVIATMSMRDRNKIALQSDLLGANDLGVTHILALTGDPANMSDQPKAKAVV 120 Query: 135 ------LVTLLKEVAD--------FDI---SVAAYPEVHPEAKSAQADLLNLKRKVDAGA 177 L+ +++ + F I + + + AK+ + + +KV A Sbjct: 121 EGSSILLLEIIRAFNNGMDYAGKEFKIKPKPITPFAVSNSYAKNFSSIERRIFKKVQNYA 180 Query: 178 NRAITQFFFD---VESYLRFRDRCVSAGID----VEIIPGILPVSNFKQAKKF-ADMTNV 229 ITQ +D VE L +++ +S D EII G P++ K A+ A + + Sbjct: 181 VGIITQPVYDINIVEKLLEIKEKVISEFNDERKEAEIILGFFPITKLKTAQFLHAHVPGI 240 Query: 230 RIP-AWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYA 285 +P W+ ++ + VG ++ ++ + L ++ H T NR E+ Sbjct: 241 YVPEEWIEKLIKAHKISEDEEYKVGMELSRNLFQQLLKKH-PKIHIMTANRFEIVKE 296 >UniRef50_A6Q7Z1 Methylenetetrahydrofolate reductase n=4 Tax=Epsilonproteobacteria RepID=A6Q7Z1_SULNB Length = 305 Score = 117 bits (295), Expect = 3e-25, Method: Composition-based stats. Identities = 48/293 (16%), Positives = 103/293 (35%), Gaps = 28/293 (9%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + ++ E PP + +++ L + K S T + + ++ Sbjct: 13 KNFITVEVNPPHGASLDKILEDIKKYKLHEKVTGFSCTDNPLAKLKMSGVLSAIRLQQTF 72 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS---DLVTL 138 ++ D L++ + +R I+AL GD S +PE+ D L Sbjct: 73 KKPVIATMSMRDKNKLSLQSTLLGANDFDLRCILALTGDPAKFSDQPEVKGVLERDSTLL 132 Query: 139 LKEVADFDISV------------AAYPEV--HPEAKSAQADLLNLKRKVDAGANRAITQF 184 L + + V YP + A++ ++ + +K+D GA ITQ Sbjct: 133 LSIIYHLNNGVDYSNKPLNPAPKPIYPFAVSNSYARNMRSLQKRIVKKLDYGARAIITQP 192 Query: 185 FFDVESYLRFRD--------RCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWM 235 +D+E+ + + + +I G P+ + A + + +P + Sbjct: 193 VYDLENAMELLELFEEAKTMSVRETSKEAHLILGQFPIVRARTANFIDDKVPGISVPKDI 252 Query: 236 AQMFD-GLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAIC 287 + D E + VG ++ + + ++ K H T NR ++ + Sbjct: 253 IDEMNLAAMDGEEKEQEVGFTLSKKIFDEMMKKHGK-VHMMTHNRFDLCSELI 304 >UniRef50_Q9HJI8 5, 10-methylenetetrahydrofolate reductase related protein n=3 Tax=Thermoplasma RepID=Q9HJI8_THEAC Length = 270 Score = 117 bits (293), Expect = 6e-25, Method: Composition-based stats. Identities = 47/274 (17%), Positives = 97/274 (35%), Gaps = 25/274 (9%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 S E P R L + D L + ++ + I + Sbjct: 17 NFVKSVEIVPSRN-FGTDDLIAAADMLDG-RVNALTCPENPRGSPGIDPIMALYIISNER 74 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL-PPGSGKPEMYASDLVTLLK 140 + PH+T D + + GIR+ + GD P E+ D++ +++ Sbjct: 75 NIIPVPHITPRDKNRVHILSQIETAQKVGIRNFFTIGGDPINPKYESREVREIDVMEIIR 134 Query: 141 EVADFD---ISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLR-FRD 196 + + + A P + + +++ K+ +GA+ I+Q + E + + Sbjct: 135 MIKGRENAIVGAALNPY-----RDVEPEIVG--AKIKSGADFFISQAVYSAEYLQKDWIK 187 Query: 197 RCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANI 256 + + ++I G LP++ Q K ++ + IP + Q ++E I Sbjct: 188 K-----RNFKLIAGFLPLTKKSQVKFSENL-GIVIPDSVKQRLL----NSEDVISTSMKI 237 Query: 257 AMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + V +E V H L E++ I T+ Sbjct: 238 ITE-VFDEVKEYVDGIHIMPLGHNEIAAQILETI 270 >UniRef50_C8R0R0 Methylenetetrahydrofolate reductase n=1 Tax=Desulfurivibrio alkaliphilus AHT2 RepID=C8R0R0_9DELT Length = 513 Score = 116 bits (290), Expect = 1e-24, Method: Composition-based stats. Identities = 51/284 (17%), Positives = 93/284 (32%), Gaps = 33/284 (11%) Query: 22 QINVSFEFFPPRTSEM---EQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 ++ E P R+ ++ L + ++ + VS+T A + I Sbjct: 15 NFTLTLELVPGRSGRGTGHDRALAVARQAVADGRLTAVSITENAGGQVALSPEVLGVEIC 74 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS---------GKPE 129 GLE HL+C D +++ + + GI ++ + GD P Sbjct: 75 A-LGLEVIVHLSCKDKNRNQMESQLFAWDRLGISDLLVITGDYPKPGYRGLSKPVFDLDS 133 Query: 130 MYASDLVTL-----------------LKEVADFDISVAAYPEVHPEAKSAQADLLNLKRK 172 + A DL+ + L + F VA P H E + L+RK Sbjct: 134 VQALDLIGVMNRGGWPSGGEKARPNPLLQTTGFVKGVALSPFKHSE-PELVMQYVKLRRK 192 Query: 173 VDAGANRAITQFFFDVESYLRFRDRCVSAGID-VEIIPGI-LPVSNFKQAKKFADMTNVR 230 + AGA+ ITQ +D + G V ++ + +P + ++ Sbjct: 193 LAAGADYIITQIGYDARKFQEVLLFLERQGQGRVPVLGNVFIPSLKVAELMYRGEIPGCV 252 Query: 231 IPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHF 274 IP + + K A ++ +L G H Sbjct: 253 IPEKLYTTMQQEARSPDRGKKARLMRAAALLAVLRGLGYAGAHI 296 >UniRef50_UPI0001698591 5,10-methylenetetrahydrofolate reductase n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2' RepID=UPI0001698591 Length = 99 Score = 114 bits (286), Expect = 4e-24, Method: Composition-based stats. Identities = 34/100 (34%), Positives = 62/100 (62%), Gaps = 1/100 (1%) Query: 15 SLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSII 74 ++ + ++SFE FPP+T + + L +I +L+ KP++ SVTYGA ++RT + + Sbjct: 1 MTSQTKTAPSISFELFPPKTGQGFENLKRTISQLNQAKPEYFSVTYGAGGSTQERTFASV 60 Query: 75 KGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHI 114 ++++ G+E APHL+CI A+ +E I + Y + G+ I Sbjct: 61 DWLREQ-GIETAPHLSCIGASVEETVAILQHYRDQGVNRI 99 >UniRef50_C7MDX6 Methylenetetrahydrofolate reductase n=1 Tax=Brachybacterium faecium DSM 4810 RepID=C7MDX6_BRAFD Length = 274 Score = 114 bits (285), Expect = 4e-24, Method: Composition-based stats. Identities = 60/269 (22%), Positives = 94/269 (34%), Gaps = 29/269 (10%) Query: 27 FEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG-ERDRTHSIIKGIKDRTGLEA 85 FE P L + + + P VT A+ T + + R G A Sbjct: 20 FEVIP---------LRGIAEEVLAQLPAGARVTVTASPAQGLPATLEVTCTL-ARHGFCA 69 Query: 86 APHLTCI-DATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVAD 144 PHL P E+ + G+R + + GD P +G+ E A DL+ +L Sbjct: 70 IPHLAARMLRDPGEVAEVLARLGEAGVREVFVIAGDAPHPAGRFEG-ALDLLEVLSPSG- 127 Query: 145 FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGID 204 + A+PE HP A A L L+ K + A A+TQ F+ L + R GI Sbjct: 128 MRAGIGAHPEGHPFLDEAAA-LSLLRAKAE-HAAYAVTQMSFEAVPLLAWTRRLREEGIT 185 Query: 205 VEIIPGILPVSNFKQAKKFADMTNVRIP--------AWMAQMFDGLDDDAETRKLVGANI 256 + + PGI ++ + + V + M ++ D A+ Sbjct: 186 LPVRPGIAAPASTARLLRIGTRIGVGRSLRLLGADGSGMLRLLGPGQWDPGPLLAQLASA 245 Query: 257 AMDMVKILSREGVKDFHFYTLNRAEMSYA 285 A + L H YT N + Sbjct: 246 AAEPGLAL-----HGPHLYTFNAVRAARE 269 >UniRef50_Q18JC7 5,10-methylenetetrahydrofolate reductase n=2 Tax=Halobacteriaceae RepID=Q18JC7_HALWD Length = 285 Score = 113 bits (284), Expect = 6e-24, Method: Composition-based stats. Identities = 52/266 (19%), Positives = 101/266 (37%), Gaps = 29/266 (10%) Query: 27 FEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEAA 86 FE P + + ++ L + +++T ++T + + G E Sbjct: 23 FELMP------FDSFNDELESLPAGSS--IAITTSP-QLGIEQTVERAEEAAAQ-GYEVV 72 Query: 87 PHLTCID-ATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVAD- 144 PH+ +L +IA + G+ + GD +G+ A DL+ +L E+ Sbjct: 73 PHIAARYVEDEAQLASIAERLSDAGVNDVFIPGGDREEPAGE-FTSAYDLLEVLDELPYS 131 Query: 145 -FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGI 203 DI + YPE H + + + + +K A +TQ +D E+ L + + G+ Sbjct: 132 FEDIGITGYPEGHDFIEDEELAMA-MDQK-APHATYIVTQLCYDPETILEWVESTRERGV 189 Query: 204 DVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV----GANIAMD 259 D+ I GI V N+++ + + V + E + + G D Sbjct: 190 DLPIEIGIPGVMNYQKLLQISQKVGV---GDSIRFLRKTTGVFEFVRQLIGSRGVYEPDD 246 Query: 260 MVKILSR------EGVKDFHFYTLNR 279 ++ LS ++ H YT N+ Sbjct: 247 LINGLSPYVEDEYYNIRGVHIYTFNQ 272 >UniRef50_UPI00019055D0 5,10-methylenetetrahydrofolate reductase protein n=2 Tax=Rhizobium etli RepID=UPI00019055D0 Length = 135 Score = 112 bits (282), Expect = 1e-23, Method: Composition-based stats. Identities = 36/92 (39%), Positives = 56/92 (60%) Query: 202 GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMV 261 GI + I+PGI+P+ N Q K+FA IP ++ + F G DD E R V A++A + + Sbjct: 33 GISIPIVPGIMPIQNVTQLKRFAGACGAVIPGFLDERFAGFDDKPEERAKVAADVAAEQI 92 Query: 262 KILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 + L R G++DFH YT+NR+ + A+ LG+ Sbjct: 93 EDLVRRGIRDFHLYTMNRSPLVSAVLDNLGLS 124 >UniRef50_C9KNQ4 Methylenetetrahydrofolate reductase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KNQ4_9FIRM Length = 247 Score = 111 bits (278), Expect = 3e-23, Method: Composition-based stats. Identities = 45/219 (20%), Positives = 81/219 (36%), Gaps = 12/219 (5%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSII-KGIKDRT 81 +S E P R + + + + + +++ R T S I Sbjct: 2 KRISVELVP-RDEDALRGELALLGKFKE-QVDVINIPD----LLRFPTRSWQGAAIAKEY 55 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKE 141 E+ PH+ +D D+ + + IR ++ + GD P E+Y ++ V ++ + Sbjct: 56 FPESMPHIRAMDIDLDKELAMKDYLREHDIREVLVIEGDPPQDMMH-EVYPTNSVDVIWK 114 Query: 142 VADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSA 201 V Y + S +L +KRK+ AGA TQ FFD +RF Sbjct: 115 FRKEMPEVKVYAGIDQYRGSLSQELYRIKRKLQAGAAGFFTQPFFD----MRFLSVYADM 170 Query: 202 GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFD 240 +E+ G+ PV + + + +V P D Sbjct: 171 LQGLEVYWGVSPVMSARSQSYWERKNHVVFPHAFEPTLD 209 >UniRef50_A6DEC7 Methylenetetrahydrofolate reductase n=1 Tax=Caminibacter mediatlanticus TB-2 RepID=A6DEC7_9PROT Length = 296 Score = 110 bits (276), Expect = 5e-23, Method: Composition-based stats. Identities = 47/296 (15%), Positives = 107/296 (36%), Gaps = 26/296 (8%) Query: 16 LAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIK 75 + ++ ++ E PP+ +E + + S T S + + Sbjct: 1 MIDINKDRLITLETTPPKLPTIEPMIEKIKKSEAYKYIDGFSTTDCPLSKLKYNSIIAAY 60 Query: 76 GIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------E 129 ++ +T D L++ + + +I+A+ GD S +P E Sbjct: 61 KLQKNFKKPVIATITMRDRNKIALQSDLLGANDLDVTNILAITGDPASMSDQPNTKAVVE 120 Query: 130 MYASDLVTLLKEVAD--------FDI---SVAAYPEVHPEAKSAQADLLNLKRKVDAGAN 178 ++ L+ +++ + F I + + + AK+ + + +KV A Sbjct: 121 GNSTLLLDIIRAFNNGMDYSGKEFKIKPKPITPFAVSNSFAKNFSSIEKKMYKKVKHYAK 180 Query: 179 RAITQFFFDVE---SYLRFRDRCVSAGIDVE---IIPGILPVSNFKQAKKF-ADMTNVRI 231 ITQ FD + + RD+ + +I G P++ K A+ + + + + Sbjct: 181 GIITQPVFDEDIAYKLISIRDKIRFEFKETREFDLIFGFFPITKLKTAQFLKSHVPGIYV 240 Query: 232 PA-WMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAI 286 P W+ ++ + VG +++ + + L + H T NR E+ + Sbjct: 241 PDEWIEKLIKAHKISEDEEYKVGLDLSKTLFEKLQKIH-PKIHIMTANRFEIVKEL 295 >UniRef50_A7HND8 Methylenetetrahydrofolate reductase n=1 Tax=Fervidobacterium nodosum Rt17-B1 RepID=A7HND8_FERNB Length = 293 Score = 110 bits (276), Expect = 5e-23, Method: Composition-based stats. Identities = 44/272 (16%), Positives = 89/272 (32%), Gaps = 29/272 (10%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + E PPR +E+ + I + S + ++VT R + I Sbjct: 11 KKRFILETLPPRGVVLEKYVDFCIKAVES-GAEIIAVTDLPMGSARVSPIAPA-HILVEK 68 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASD------- 134 G++ H + + GI++++ L GD P P + Sbjct: 69 GIDVIMHFSRTTRNAIRIEGDLIASHMLGIKNLLILSGDDPRVGTYPFSSCIEDFSIYDV 128 Query: 135 --LVTLLKE----------VADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAIT 182 LV LL E F + P K + + + K++ G ++ Sbjct: 129 FKLVKLLNEKGEDLAGLKIFGKFSFNSGGV--FSPFEKDYKQTIQRMNTKIETGCLFFVS 186 Query: 183 QFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGL 242 Q F+ + L F + + +I ++ + +Q + F+ + V +P Sbjct: 187 QPVFNESTILNFLKKAEGDLNETKIYVSLMVFESVQQLEYFSKVPGVFVPKEYF-----H 241 Query: 243 DDDAETRKLVGANIAMDMVKILSREGVKDFHF 274 D K + +++ L V+ F+ Sbjct: 242 QKDDRALKNYSYKNCLGIIEKL-SPYVQGFYL 272 >UniRef50_A8A9S7 Methylenetetrahydrofolate reductase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=A8A9S7_IGNH4 Length = 329 Score = 109 bits (274), Expect = 8e-23, Method: Composition-based stats. Identities = 51/275 (18%), Positives = 91/275 (33%), Gaps = 43/275 (15%) Query: 22 QINVSFEFFP--PRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 VS E P P ++R S + ++VT + Sbjct: 72 DFAVSAEVEPWGP----------EELERASKWRVDALNVTDNPLGLPHLDSV-WASAALA 120 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLL 139 G E LTC T + L + +G+ +++AL GD P + ++ A LV L+ Sbjct: 121 SKGKEVIAQLTCRGRTREALASSLLALDASGVNNVLALTGDWAPNA-AFDLDAVRLVCLV 179 Query: 140 KEVAD-------------FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFF 186 + + + VA+ P E K L RK AGA A TQ F Sbjct: 180 QALRKGVDWEGRKTRRVRLSVGVASNPYFSYEEK-------RLLRKAHAGAQFAQTQPVF 232 Query: 187 DVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDA 246 E + + + +P +L ++ K + + V + + Sbjct: 233 KKELLYKIKK------YPLPTVPSLLLTTSRKVVRALMER-GVDA-KEFYEELVKAKREG 284 Query: 247 ETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAE 281 + +LV +++M + + H R + Sbjct: 285 KADELV-LKKSLEMYEEAYSSELPGVHLMAPGRPD 318 >UniRef50_C3XLP8 Methylenetetrahydrofolate reductase n=1 Tax=Helicobacter winghamensis ATCC BAA-430 RepID=C3XLP8_9HELI Length = 307 Score = 107 bits (269), Expect = 4e-22, Method: Composition-based stats. Identities = 54/313 (17%), Positives = 121/313 (38%), Gaps = 32/313 (10%) Query: 1 MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDR---LSSLKPKFVS 57 M F +++ ++ L +G+ ++EF P S + L+ + L L F+ Sbjct: 1 MPGFESNKIESFIDKL--QKGKKCYTYEFSAP-ASFCLEKLFCGLKNQSFLQELD-AFI- 55 Query: 58 VTYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVAL 117 T + +++ + + ++ D L++ + +R ++AL Sbjct: 56 CTDSPLGKLKHSPILASLKLQNTFKIPSIATISMRDKNTLALQSELIGMNSLDLRLVLAL 115 Query: 118 RGDL------PPGSGKPEMYASDLVTLL------KEVADFD---ISVAAYPEV--HPEAK 160 GD P G E ++ L+ ++ K++ + I YP + AK Sbjct: 116 TGDPLRLGNQPQAKGVFEGNSALLLKIIDALNLNKDINGENLQGIPKRIYPFCVLNSYAK 175 Query: 161 SAQADLLNLKRKVDAGANRAITQFFFD---VESYLRFRDRC-VSAGIDVEIIPGILPVSN 216 + ++ ++ K+ GA TQ +D + L++ D + + ++ G P+++ Sbjct: 176 NKESLYKKMREKIRNGALAIFTQPIYDESIAKELLKWCDAINLEFRTNCALVFGFFPIAS 235 Query: 217 FKQAKKFA-DMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY 275 +K A + V + + + + + VG + ++ K LS + FHF Sbjct: 236 YKTALFLHYKLPGVFVSQEWLKALEIAKKNGKE-AEVGLQKSKELFKALSAL-QQKFHFM 293 Query: 276 TLNRAEMSYAICH 288 + N+ E+ I Sbjct: 294 SANKPEIIAQILK 306 >UniRef50_C7MZV4 Methylenetetrahydrofolate reductase n=1 Tax=Saccharomonospora viridis DSM 43017 RepID=C7MZV4_SACVD Length = 292 Score = 107 bits (267), Expect = 6e-22, Method: Composition-based stats. Identities = 60/294 (20%), Positives = 109/294 (37%), Gaps = 26/294 (8%) Query: 1 MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY 60 M+ + LA++ G N+S+E P ++ E + + + P V+VT Sbjct: 1 MTTKSEVADSRRPRGLADLVG--NISYEVMPFKSVE-----RAVLADVPTSIPLTVTVTE 53 Query: 61 GANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDA-TPDELRTIARDYWNNGIRHIVALRG 119 D T + + R G PHL + +R + G+ + + G Sbjct: 54 AKG---IDTTLDFTERLM-RHGYTVTPHLAARQFVDDNHVREVIDRLQTAGVNSVFIVGG 109 Query: 120 DLPPGSGKPEMYASDLVTLLKEVAD-FD-ISVAAYPEVHPEAKSAQADLLNLKRKVDAGA 177 D P +G+ A L+ ++E+ F + + YPE H + +L LK+K A Sbjct: 110 DAPKPAGRFHS-AYMLLQAMQELGHPFSEVGIGGYPEGHANIPQSDIELA-LKQKAPL-A 166 Query: 178 NRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQ 237 R +TQ FD + + +GID+ I G+ N ++ + + + A Q Sbjct: 167 TRILTQICFDANTTANWAAGVAKSGIDLPIYVGMPGPVNRQKLVRISAGIGLGQSARFLQ 226 Query: 238 MFDGLDDDAETRKLVGANIAMDMVKIL------SREGVKDFHFYTLNRAEMSYA 285 L L G + + L R ++ H +T N + + Sbjct: 227 KQQNL---LWRFLLPGGYNPTKLARRLGSAVPKVRSNIRGLHIFTFNEIQKTEQ 277 >UniRef50_Q9EYI8 Methylenetetrahydrofolate reductase n=2 Tax=Actinomycetales RepID=Q9EYI8_STRNO Length = 284 Score = 106 bits (265), Expect = 9e-22, Method: Composition-based stats. Identities = 53/278 (19%), Positives = 90/278 (32%), Gaps = 34/278 (12%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 S E T + L + D + +++T+ A T R G Sbjct: 9 FSLEM----TGKDVPRLEEARDGIPPG--TRINITFLAGEDTA--TRLTAARAVKRLGFV 60 Query: 85 AAPHLTCIDA-TPDELRTIARDYWNNG-IRHIVALRGDLPPGSGKPEMYASDLVT--LLK 140 PH++ + L +G ++ + GD G P A ++ LL+ Sbjct: 61 PVPHISARRLPSRPALEEFLAGLAAHGTAENVFVVGGDPARPEG-PYADALAVLRTGLLR 119 Query: 141 EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDA------GANRAITQFFFDVESYLRF 194 + +A YPE HP +A L K A G + ITQF FD + L + Sbjct: 120 RHGVRHVGIAGYPEGHPGITD-RALWSALTDKAAAIDADRFGGD-VITQFGFDADPVLAW 177 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQM-------FDGLDDDAE 247 + + G+ + + G+ + ++ +A V A +A+ G Sbjct: 178 LEALRARGVRLPVRVGVPGPAGVRRLLGYATRFGVGTSASVARKYGFSLTNLMGTTGPDR 237 Query: 248 TRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYA 285 + R GV HFYT + Sbjct: 238 FLHALADRY------DPGRHGVVKVHFYTFGGLRATAE 269 >UniRef50_B1ZRF7 Methylenetetrahydrofolate reductase n=2 Tax=Verrucomicrobia RepID=B1ZRF7_OPITP Length = 538 Score = 106 bits (265), Expect = 1e-21, Method: Composition-based stats. Identities = 46/250 (18%), Positives = 84/250 (33%), Gaps = 32/250 (12%) Query: 54 KFVSVTYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRH 113 ++S+T A + ++ K I G E HLTC D + L + A + G + Sbjct: 49 DWISITDNAGGNPQLAPTALGKPIL-YAGKEVVIHLTCKDLNRNALESEAWLLHSEGFNN 107 Query: 114 IVALRGDLP---PGSGKPEMYASDLVTLLK-----------------------EVADFDI 147 I+A+ GD P G ++ D V L+ E +F + Sbjct: 108 ILAMTGDYPVAGAGGTAKPVFDIDSVGLISMLDQMNRGLDPNVGQSGPRKPRFEGTNFLV 167 Query: 148 S-VAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVE 206 V ++H L K+ GA I Q FD + + Sbjct: 168 GAVTTNFKLH--EGEVMPQYAKLAAKIGVGARFIINQIGFDARKQSELLAYLRAHELGHV 225 Query: 207 IIPGILPVSNFKQAKKFAD--MTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKIL 264 + G + + + + A+ FA+ + V + + ++ A+ K A + I Sbjct: 226 PLIGNVYLLSPRVAELFAEGRIPGVVVSPALRELCRRHAGGADGGKAFFTEFAAKQIAIY 285 Query: 265 SREGVKDFHF 274 G + + Sbjct: 286 RGLGYRGVYL 295 >UniRef50_C4DNM1 Methylenetetrahydrofolate reductase n=1 Tax=Stackebrandtia nassauensis DSM 44728 RepID=C4DNM1_9ACTO Length = 289 Score = 106 bits (265), Expect = 1e-21, Method: Composition-based stats. Identities = 68/305 (22%), Positives = 104/305 (34%), Gaps = 43/305 (14%) Query: 1 MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY 60 MS A R + ++ + + + FE P +DR + P+ +VT Sbjct: 1 MSMSAALSRVRMRRTASRLLAEPR--FEVLP----------LERVDREVAALPRGTTVTI 48 Query: 61 GANSG-ERDRTHSIIKGIKDRTGLEAAPHLTCIDATPD-ELRTIARDYWNNGIRHIVALR 118 A+ T + GL PHL+ D EL + + + GIR + Sbjct: 49 TASPSRGTMATVETAERFAA-LGLRPVPHLSARGMRDDAELVEVVQRLDHAGIRDAFVVG 107 Query: 119 GDLPPGSGKPEMYASDLVTLLKEVADF-----DISVAAYPEVHPEAKSAQADLLNLKRKV 173 GD S ++ L LL+ + D DI + AYPE HP + L K Sbjct: 108 GD---ASSASAVFPDGL-ALLQAMDDIGHRLHDIGIPAYPEGHP-SIDDDTLWAALAAKR 162 Query: 174 DAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPA 233 A A+TQ FD E+ RF + G D+ I+ GI + + + + Sbjct: 163 RY-ATYAVTQLCFDAEAICRFTVQARQRGFDLPILAGIPGAVDTAKLLRVGLRIGIGDSL 221 Query: 234 WMAQ----------MFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMS 283 + G D RKL G V+ R + H YT N + Sbjct: 222 RFVRGNRSVLRKLLRPGGYRPDGLVRKLDG------RVRD-GRCELAGAHIYTFNDVAAT 274 Query: 284 YAICH 288 Sbjct: 275 ARWLK 279 >UniRef50_B0VPR6 Methylenetetrahydrofolate reductase n=15 Tax=Acinetobacter RepID=B0VPR6_ACIBS Length = 470 Score = 104 bits (261), Expect = 3e-21, Method: Composition-based stats. Identities = 38/203 (18%), Positives = 75/203 (36%), Gaps = 14/203 (6%) Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD-----LPPGSGKPEMYASDLV 136 +E H + + + I++++ L GD G+P + V Sbjct: 70 SIEKVLHFSGKARDIQDFERFLEQAKSANIQNLLLLTGDKLKEHHNGRDGQPRSRYLESV 129 Query: 137 TLL---KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLR 193 + K+ F I VA P + EA+ A L L +K+ AGA+ ITQ +D+E+ + Sbjct: 130 NAVMAAKQHGGFRIGVAFNPFKYVEAE-RDAQYLKLHKKIKAGADFIITQLGYDIEALKQ 188 Query: 194 FRDRCVSAGIDVEIIPGILPVS-NFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV 252 + +I+ ++P++ + + I M ++ T ++ Sbjct: 189 AKSFLTKHDYSQQILACVMPLTLGRANFMVKHKVAGIVITPHMLKVLAEEKQTGHTDRVY 248 Query: 253 -GANIAMDMVKILSREGVKDFHF 274 + + + K L G H Sbjct: 249 LRCALQILICKHL---GFAGIHL 268 >UniRef50_D0XP42 Methylenetetrahydrofolate reductase n=1 Tax=Brevundimonas subvibrioides ATCC 15264 RepID=D0XP42_9CAUL Length = 293 Score = 104 bits (260), Expect = 4e-21, Method: Composition-based stats. Identities = 61/266 (22%), Positives = 104/266 (39%), Gaps = 26/266 (9%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 S E T++ +L + R + +++ + R H+ ++ G + Sbjct: 22 FSLEM----TAKDVPSLEEAA-RFIPQGTR-IAIAFLPGETFEARLHAAVRV--RALGFD 73 Query: 85 AAPHLTCID-ATPDELRTIARDYW-NNGIRHIVALRGDLPPGSGKPEMYASDLVT--LLK 140 APH++ A+ ELRT + GI+ + + GD P G P A L+ +L Sbjct: 74 PAPHISARRIASETELRTFLERLAADAGIKRLFVVAGDPPVPEG-PYEDALSLIRSGMLA 132 Query: 141 EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDA----GANR-AITQFFFDVESYLRFR 195 + + V+ YPE HP+ + K DA G + +TQF FD + + + Sbjct: 133 GLNLESVGVSGYPEGHPD-IDGDKLWRAMFDKRDALGELGISMTILTQFGFDPDPIVDWI 191 Query: 196 DRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQM----FDGLDDDAETRKL 251 + + GID I G+ + K +FA V A + L A +L Sbjct: 192 AQVRAHGIDALIRIGVPGPAGIKTLMRFAARCGVGTSAKVMSRYGLSITQLIGSAGPDRL 251 Query: 252 VGANIAMDMVKILSREGVKDFHFYTL 277 +G ++A + R G HFY Sbjct: 252 IG-DLAARI--DPVRHGDLSLHFYPF 274 >UniRef50_C5F201 Methylenetetrahydrofolate reductase n=2 Tax=Helicobacter RepID=C5F201_9HELI Length = 303 Score = 103 bits (258), Expect = 7e-21, Method: Composition-based stats. Identities = 45/293 (15%), Positives = 108/293 (36%), Gaps = 30/293 (10%) Query: 20 QGQINVSFEF-FPPRTSEMEQTLWNSI--DRLSSLKPKFVSVTYGANSGERDRTHSIIKG 76 + ++EF PP S T ++++ + L S F+ T + + + Sbjct: 13 SNEKCFTYEFSAPP--SFSLDTFFDALQQENLVSKIHAFI-CTDSPLAKLKHNSILASLK 69 Query: 77 IKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS--- 133 +++ L + ++ D +++ + +R I+AL GD +P+ Sbjct: 70 LQNTFNLPSITTISMRDRNTLAIQSELIGMNSLDLRLILALTGDPIRHGNQPQAKGVFEG 129 Query: 134 ---------DLVTLLKEVADFDISVAAYPEV-----HPEAKSAQADLLNLKRKVDAGANR 179 + K++ + I P + + + ++ K+ GA+ Sbjct: 130 NSLLLLKIIQQLNQAKDINNHPIQGDFKPFYAFSVLNSYSNKKENLYKKMQEKIQNGASA 189 Query: 180 AITQFFFDVE---SYLRFRDRC-VSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAW 234 ITQ +D++ L++ D+ + + +I G P++++K A + V IP Sbjct: 190 IITQPIYDLDIAQELLQWCDKINQESSTNCTLIFGFFPITSYKTALFLHNKLPGVFIPQS 249 Query: 235 MAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAIC 287 + + + +G + + + L + K H + N+ ++ I Sbjct: 250 WLETMEKASHNNTEL-EIGLEKSQRLFENLCKIQAK-IHLMSSNKVDIIGKIL 300 >UniRef50_A4FL79 Methylenetetrahydrofolate reductase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FL79_SACEN Length = 282 Score = 101 bits (253), Expect = 2e-20, Method: Composition-based stats. Identities = 49/284 (17%), Positives = 100/284 (35%), Gaps = 35/284 (12%) Query: 27 FEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG-ERDRTHSIIKGIKDRTGLEA 85 FE P L ++++ +L P+ +VT ++ + T + + G Sbjct: 19 FEVLP---------LRGVVEQVGNL-PEGTTVTVTSSPKKGVEATLDVAARV-RGLGHHV 67 Query: 86 APHLTCIDAT-PDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVAD 144 PHL T P L + G+ + A+ GD +G P A L+ ++E+ Sbjct: 68 VPHLAARLLTGPAHLAAVLDRIEGLGMTEVFAVAGDSAEPAG-PYPDALSLLRAMEELGR 126 Query: 145 --FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAG 202 + + YPE H A + + K A A+ ++Q +D + + + G Sbjct: 127 RPSRVGITGYPERHAFIPDATT-ISAMSEK-AAHADYIVSQICYDPHALASWVKDVRARG 184 Query: 203 IDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIA-MDMV 261 + + I G+ V + + + + + + L + ++ Sbjct: 185 VVLPIHIGVPGVVDVHRLLRISLKIG------LGESMRFLRKQHGVVTKLLTRYTPEELF 238 Query: 262 KILSRE------GVKDFHFYTLNRAEMS----YAICHTLGVRPG 295 LS G+ +HF+T N + + + +G P Sbjct: 239 DELSPHLADPAYGIAGWHFFTFNEVDRTDRWRQDLLARIGEVPA 282 >UniRef50_Q251W5 Methylenetetrahydrofolate reductase n=3 Tax=Bacteria RepID=Q251W5_DESHY Length = 561 Score = 101 bits (251), Expect = 4e-20, Method: Composition-based stats. Identities = 48/291 (16%), Positives = 90/291 (30%), Gaps = 32/291 (10%) Query: 12 LNQSLAEVQGQINVSFEFFPPRTS---EMEQTLWNSIDRLSSLKPKFVSVTYGANSGERD 68 QSL + ++V++E P R + E L + K +++T Sbjct: 43 FKQSLLD-PNTLSVTWELVPGRGAREKAQESALLAAEQAAKGGKVHALTITDNPGGNPAI 101 Query: 69 RTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD-------- 120 + + I G+E H TC D +++ + +R ++ + GD Sbjct: 102 LADYLGQEILK-LGIEPLVHFTCKDKNRNQMESQLYALDRAEVRSLLVMTGDYTVSGFKG 160 Query: 121 -LPPGSGKPEMYASDLVTLL--------------KEVADFDISVAAYPEVHPEAKSAQAD 165 P + +L+ + + +DF A P EA+ Sbjct: 161 RPKPVFDLDPTHTLELIAQMNEGLGIPGPKGMSYHQPSDFFAGAAVSPFKGTEAEQM-VQ 219 Query: 166 LLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPG--ILPVSNFKQAKKF 223 LK+KV +GA +TQ +D ++V ++ ILP K Sbjct: 220 YYKLKKKVTSGAQFIVTQLGYDARKIHEVLQFMKLNDLNVPLVGNIYILPFGAAK-IMNQ 278 Query: 224 ADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHF 274 + + + D + A M ++ G H Sbjct: 279 NQLPGCVVTDKLLAEIDKERTAEDKGVSARLLRAAKMYALMKGMGFAGVHI 329 >UniRef50_C0QKT3 Methylenetetrahydrofolate reductase n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QKT3_DESAH Length = 294 Score = 100 bits (249), Expect = 8e-20, Method: Composition-based stats. Identities = 56/297 (18%), Positives = 102/297 (34%), Gaps = 33/297 (11%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSI-IKGIK 78 G+ + PP+ +++ + N+I + VS R S+ + Sbjct: 9 TGEFARLVQIDPPKGTDVITMVNNAIKVKGVVDAFLVS----EMKSAVMRMTSLGASLVL 64 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS-DLV- 136 + GL+ L+C D L+ GI + + GD P + A DL Sbjct: 65 QQKGLDTIVQLSCRDRNRLALQGDLLAASALGIAAAMVVEGDPPATGDHVDAKAVYDLTD 124 Query: 137 -TLLKEVADFDIS---VAAYPEVHPEAK------------SAQADLLNLKRKVDAGANRA 180 L+K +A + + +L +KR +D G Sbjct: 125 EALVKAIASLSKGRDLAGVELAGSVDLPMGVELSTGLRGGEREKELDRMKRMIDLGVCFF 184 Query: 181 ITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNVRIPAWMAQMF 239 +TQ F+ F V G+ IIP +L V + A+ A ++ ++ +P + Sbjct: 185 VTQPLFEFSMTEPFLKIAVKNGVT--IIPTVLLVKSLGMARYMARNLAHIIMPEHVIDTL 242 Query: 240 DGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 D + ++A+DM+ + G + L + + LGV GL Sbjct: 243 QKTPDKVKA----SISLAVDMIHEVREMGFGGVNVSCLGWEDKLPEV---LGVMKGL 292 >UniRef50_A6DQ26 Methylenetetrahydrofolate reductase n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DQ26_9BACT Length = 255 Score = 99.1 bits (246), Expect = 2e-19, Method: Composition-based stats. Identities = 38/218 (17%), Positives = 69/218 (31%), Gaps = 16/218 (7%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 +S E P + + + + PK +V R+ + Sbjct: 4 ISIELVP----HAAEEITCELKGIQEAFPKVNTVNIPDIVRLPTRSWEACGFCAPMLERD 59 Query: 85 AAPHL-TC-IDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEV 142 PHL C D + +L + ++ + GD G + D + K Sbjct: 60 -IPHLRACDFDLSKAQLLHDIMAEYK--FDEVLLVGGDFFEGREHFDTSTVDFIKFFKTN 116 Query: 143 ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAG 202 V Y + P + ++ LK K+ G + TQ FFD+E ++ + Sbjct: 117 Y---PDVKVYGAIDPYRADFETEMKYLKEKMAVGIDGFFTQPFFDLELLAKWIEALK--- 170 Query: 203 IDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFD 240 D + G+ PV + K + V P + Sbjct: 171 -DQVVYWGLSPVLSAKSQAYWEKRNLVNFPKDFVPELE 207 >UniRef50_UPI0001C31E0D methylenetetrahydrofolate reductase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31E0D Length = 273 Score = 98.7 bits (245), Expect = 2e-19, Method: Composition-based stats. Identities = 55/240 (22%), Positives = 96/240 (40%), Gaps = 14/240 (5%) Query: 53 PKFVSVTYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCID-ATPDELRTIARDYWNNGI 111 P +++T G + T ++ + + G PH+ A L T+ GI Sbjct: 22 PVTLTITCSPRLGV-EHTLTVAERARA-LGHRVVPHVAARMVADRSHLDTLMERLAAAGI 79 Query: 112 RHIVALRGDLPPGSGKPEMYASDLVTLLK--EVADFDISVAAYPEVHPEAKSAQADLLNL 169 + + GD +G + A +L+ L+ E+ I + AYPE HP L Sbjct: 80 DDVFLIGGDAAAPAGAFDS-AVELLPLMHAHELRPRRIGIGAYPEGHP-LVDRATLADAL 137 Query: 170 KRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNV 229 RK A A+ +TQ FD + LR+ ++ +AG+D+ G+ + ++ + + V Sbjct: 138 CRK-AAFADYMVTQLCFDPAALLRWIEQTRAAGVDLPSYVGLPGAVDRRRLLEVSMRVGV 196 Query: 230 RIPAWMAQMFDG----LDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYA 285 + G L + +GA A +V ++ HFYT NR + A Sbjct: 197 GDSIGFLRKQRGIRRLLSRPERAVERLGAAFAP-LVGE-PELAIEGLHFYTFNRLRATLA 254 >UniRef50_A0L7S2 Methylenetetrahydrofolate reductase n=2 Tax=cellular organisms RepID=A0L7S2_MAGSM Length = 253 Score = 98.3 bits (244), Expect = 3e-19, Method: Composition-based stats. Identities = 47/254 (18%), Positives = 84/254 (33%), Gaps = 25/254 (9%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 +S E P + L + I R+ P+ ++ R+ KD Sbjct: 9 RLSVELVP----RDVEVLKDEIKRVHQHFPQITTINIPDLVRYPIRSWDGCVLAKDHFSS 64 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVA 143 A PHL +D + + NGI ++ + GD P D + +++ Sbjct: 65 -AIPHLRAMDMPEQPILPMLDVLDANGITEVLVISGDEPVAGEVHRG--PDSLEIIQRFK 121 Query: 144 DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGI 203 + Y + P + Q +L ++K++AGA TQ FFD + D+ Sbjct: 122 TLAPHIKVYAALDPYRTNIQHELAYAQQKLEAGAAGLFTQPFFDHRLMQIYADQLQ---- 177 Query: 204 DVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKI 263 + G+ PV ++ + V PA A +DM+ Sbjct: 178 GCAVWWGLSPVVTEASKNYWSRVNRVVFPASFQADL--------AWNQAFARDVLDMIHE 229 Query: 264 LSREGVKDFHFYTL 277 + H Y + Sbjct: 230 M------GHHIYFM 237 >UniRef50_A0JQZ4 Methylenetetrahydrofolate reductase n=1 Tax=Arthrobacter sp. FB24 RepID=A0JQZ4_ARTS2 Length = 302 Score = 97.2 bits (241), Expect = 6e-19, Method: Composition-based stats. Identities = 45/224 (20%), Positives = 69/224 (30%), Gaps = 14/224 (6%) Query: 68 DRTHSIIKGIKDRTGLEAAPHLTCIDAT-PDELRTIARDYWNNGIRHIVALRGDLPPGSG 126 +RT + G PHL EL I RD +GI + + GD Sbjct: 40 ERTMRAAVQL-GVLGYSVIPHLAARSVPGRSELTGILRDCDVSGINEVFVIGGDR-KQPA 97 Query: 127 KPEMYASDLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQF 184 P + L+ + + VA YPE HP L L K A+ +TQ Sbjct: 98 GPYASSLPLLEDIAQYTGGRMRAGVAGYPEGHPSVGPVDL-LDALLAKQHL-ASNVVTQM 155 Query: 185 FFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDD 244 F L F G+ + + G+ + A V Sbjct: 156 CFSAPKILDFAALLRREGVQLPVWAGVAGTVPRTKLVSLATQIGVGSSLKFLSR----KG 211 Query: 245 DAETRKLVGANIAMD-MVKILSR-EGV-KDFHFYTLNRAEMSYA 285 + L G + + +V L G+ H Y+ N + + Sbjct: 212 PLARKLLSGDRYSPESLVAGLESPAGIFAGIHLYSFNNLDPAPG 255 >UniRef50_Q3BYU2 Methylenetetrahydrofolate reductase n=16 Tax=cellular organisms RepID=Q3BYU2_XANC5 Length = 325 Score = 96.4 bits (239), Expect = 1e-18, Method: Composition-based stats. Identities = 45/215 (20%), Positives = 83/215 (38%), Gaps = 19/215 (8%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 S E +++ L N+ R+ F+ Y + R + G Sbjct: 42 AYSLEV----SAKDIGALTNAAPRILPGCAMFI--PYLPGQNQAVRLA--AAQMVRSLGF 93 Query: 84 EAAPHLTCIDA-TPDELRT-IARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVT--LL 139 E PHL+ + EL+ IAR G+ + + GD P P + L+ + Sbjct: 94 EPVPHLSARRIGSLGELQACIARLVDEAGVTRCLVIAGD-PSTPKGPFPDSVSLIETGVF 152 Query: 140 KEVADFDISVAAYPEVHPEAKSAQADLLNLKRK----VDAG-ANRAITQFFFDVESYLRF 194 + I+VA +PE HP ++ + L+RK + G A +TQF FD + + + Sbjct: 153 ERSGIRTIAVAGHPEGHPILRTTE-QWEVLERKCRSIQERGMAPLIVTQFGFDADIVVTW 211 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNV 229 + + G+ + G+ ++ ++A V Sbjct: 212 LEALRARGMTHPVRVGVPGPASVAVLARYAASCGV 246 >UniRef50_B9KZH8 Methylenetetrahydrofolate reductase n=2 Tax=Thermomicrobia (class) RepID=B9KZH8_THERP Length = 299 Score = 96.4 bits (239), Expect = 1e-18, Method: Composition-based stats. Identities = 50/233 (21%), Positives = 87/233 (37%), Gaps = 20/233 (8%) Query: 57 SVTYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCID-ATPDELRTIARDYWNNGIRHIV 115 +VT G + T + + + G PHL + EL + + + GI + Sbjct: 51 TVTSSPAHGVK-GTLATALAL-RQHGYRVVPHLAARALRSHQELVLLWQQFVAAGIDEVF 108 Query: 116 ALRGDLPPGSGK-PEMYA--SDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRK 172 + GD +G+ P+ + LV L + I +AAYPE HP + D L + Sbjct: 109 VVGGDQTEPAGEFPDSRTLLTALVEL--QPRPRRIGIAAYPEGHPHIPADVLDADLLTK- 165 Query: 173 VDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIP 232 A A+ AITQ FD ++ +R+ R S G + + + + + + Sbjct: 166 -QALADYAITQLVFDPDALVRWLTRMRSRGFTLPLYLCLPGTLRLDRLIRIGLRLGLGTS 224 Query: 233 AWMAQMFDGLDDDAETRKLVGANI-AMDMVKILSRE------GVKDFHFYTLN 278 + GL G + D++ L R G+ H+ + N Sbjct: 225 LRYLEKQRGLVG---RLLTGGIHYDPSDLLDELVRRPAAIQGGIVGIHWSSFN 274 >UniRef50_Q2G4C7 Methylenetetrahydrofolate reductase n=1 Tax=Novosphingobium aromaticivorans DSM 12444 RepID=Q2G4C7_NOVAD Length = 294 Score = 96.0 bits (238), Expect = 1e-18, Method: Composition-based stats. Identities = 51/271 (18%), Positives = 93/271 (34%), Gaps = 37/271 (13%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 S E T++ E +L ++ + + P ++VT+ R + + + G E Sbjct: 22 FSLEM----TAKDEASLRDAAPLIPADTP--IAVTFLPGEDVAARVAATVAVRQ--LGFE 73 Query: 85 AAPHLTCIDATPDE-----LRTIARDYWNNGIRHIVALRGDLP-PGSGKPEMYASDLVTL 138 PH + T ++ L+ + G+ + GD P P + A Sbjct: 74 PMPHFSARRITSEDDFEGYLKAVVEQA---GVERCFIVAGDPPEPVGPYFDTSALIATGA 130 Query: 139 LKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDA----G-ANRAITQFFFDVESYLR 193 + I + +PE HP A+ L++KV G A +TQF FD +++L Sbjct: 131 FERSGIKAIGIGGHPEGHPNMTEAEC-WAVLEKKVAEIERRGMAPLIVTQFGFDPDAFLA 189 Query: 194 FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQM-------FDGLDDDA 246 + + GID + G+ + K+ FA V + + G Sbjct: 190 WLKELRARGIDAPVRIGVPGPAGIKRLLAFAARCGVGASTAVLKKYGISVTNLLGTAGPD 249 Query: 247 ETRKLVGANIAMDMVKILSREGVKDFHFYTL 277 + + + G HFY Sbjct: 250 KLVDAFAKGLGPE-------HGKVRLHFYPF 273 >UniRef50_A5EXW9 Methylenetetrahydrofolate reductase n=1 Tax=Dichelobacter nodosus VCS1703A RepID=A5EXW9_DICNV Length = 288 Score = 94.5 bits (234), Expect = 3e-18, Method: Composition-based stats. Identities = 51/281 (18%), Positives = 96/281 (34%), Gaps = 34/281 (12%) Query: 25 VSFEFFPPRTSEMEQTLWNS-IDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 S E P + +E ++ VT+ N + T + + GL Sbjct: 13 YSLEVTP-KFAESIANFTAYFAKETAAY------VTFLPN-SDFLSTIR-ATVLLQQNGL 63 Query: 84 EAAPHLTCID-ATPDELRTIARDYWNNGIRHIVALRG--DLPPGSGKPEMYASDLVT--L 138 PH+ + EL ++ G+R ++ + G D P G P L+ + Sbjct: 64 RTVPHIAARSLHSEAELEQGLAQLYDAGVRDLLLIAGSIDQPRG---PWASTLALLASGI 120 Query: 139 LKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGAN------RAITQFFFDVESYL 192 ++ I AA+PE HP +LL ++ A A+ +TQF F + + Sbjct: 121 IQNYQWHSIGFAAHPEGHPRIG--ADELLYTLQQKQAFADSISAQCYLLTQFCFTAKPIV 178 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV 252 + + GI + I G+ V+ ++A + + + + Sbjct: 179 HWHRMLQTQGIRLPIHLGVPGVTTIGNLFRYAQLCGI---GNSVRFLRYSQHGLHQFLEL 235 Query: 253 GA-NIAMDMVKILSREG----VKDFHFYTLNRAEMSYAICH 288 + + + +G +K HFY L E + H Sbjct: 236 STPELLLSNIVRARAQGELSLLKCLHFYPLGGFEATVRWIH 276 >UniRef50_D1B0C6 Methylenetetrahydrofolate reductase n=1 Tax=Sulfurospirillum deleyianum DSM 6946 RepID=D1B0C6_SULD5 Length = 304 Score = 94.1 bits (233), Expect = 6e-18, Method: Composition-based stats. Identities = 47/281 (16%), Positives = 99/281 (35%), Gaps = 33/281 (11%) Query: 38 EQTLWNSIDRLSSLK----PKFVSVTYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCID 93 E T I++++ L S T + + +++R ++ D Sbjct: 24 EPTFEPIIEKIAQLGLDKKVDGFSTTDNPLARLKYNALFGALKLQNRFHKPVIATMSMRD 83 Query: 94 ATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYASDLVTLLKEVADFDI 147 L++ N +R I+ L GD S +P E ++ L+ +++ I Sbjct: 84 RNKLALQSDLLGANENDLRTILCLTGDPASASDQPALKGVFEGNSTLLMDIIQCFNA-GI 142 Query: 148 SVAA----------YPE--VHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFR 195 + YP + A + + + + K+ GA ITQ + +E+ Sbjct: 143 DYSGKPFKTQPKPIYPFAVCNAHANTPRHLMKKMATKMSHGAVGIITQPVYSMENATMLV 202 Query: 196 DRCVSAGIDV-------EIIPGILPVSNFKQAKKF-ADMTNVRIPA-WMAQMFDGLDDDA 246 + A ++ E+I G P+ + A+ A + V +P WM ++ Sbjct: 203 ELLKEAKKEIGKETHEAELILGFFPIIKLRTAQFLSAHVPGVHVPTLWMEKLAHAKKISE 262 Query: 247 ETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAIC 287 VG +++ ++L + H + N E+ + Sbjct: 263 AEEHKVGFELSLQTFRMLKKVH-PKIHMMSANNFELIADLL 302 >UniRef50_C0QY90 Methylenetetrahydrofolate reductase n=2 Tax=Brachyspira RepID=C0QY90_BRAHW Length = 308 Score = 91.4 bits (226), Expect = 3e-17, Method: Composition-based stats. Identities = 50/298 (16%), Positives = 105/298 (35%), Gaps = 28/298 (9%) Query: 18 EVQGQINVSFEFFP-PRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKG 76 E + + + E P + ++S FV VT + + + Sbjct: 14 ENKDEYTFTLEISPQAKFDLGYIKDKIDDAKISDYIDAFV-VTDSPFANLKISSILAALQ 72 Query: 77 IKDRTGL--EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK------P 128 ++ R T D L+ IR ++A+ GD G + Sbjct: 73 LQQRLNNNKPFIATQTMRDKNSIALQNDLIGANYFDIRMVLAVTGDPINGGNQKQAKSVF 132 Query: 129 EMYASDLVTLLKE------VADFDIS---VAAYPE--VHPEAKSAQADLLNLKRKVDAGA 177 E + L+ ++K+ + +F YP ++ AK+ + + L +K ++G Sbjct: 133 EGNSELLIAIIKDLNKGKSLGEFAFKEPLKPIYPFCVINSYAKNNDSLKVRLAKKANSGV 192 Query: 178 NRAITQFFF---DVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIP- 232 TQ + +E L + D + ++PG PV +K A + IP Sbjct: 193 KAIFTQPIYEAERLELLLEWIDELPLKNKPI-LVPGFFPVLTYKTAYFIYYKLPGAYIPE 251 Query: 233 AWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 W+ ++ + E K V ++ D+ + ++ K H ++N + ++ + Sbjct: 252 DWLNKLKKASNKSPEEEKRVAVKLSSDLFHNMLKKH-KKMHIMSMNNYDFVVSLLKNI 308 >UniRef50_A8TJJ1 MetFprotein-like protein n=2 Tax=Bacteria RepID=A8TJJ1_9PROT Length = 308 Score = 90.6 bits (224), Expect = 6e-17, Method: Composition-based stats. Identities = 48/240 (20%), Positives = 80/240 (33%), Gaps = 29/240 (12%) Query: 56 VSVTYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCID-ATPDELRTIARDYW-NNGIRH 113 V+VT+ + T ++ K ++ G E PH+ A L + G+ Sbjct: 41 VNVTFLPG-SDPADTVAVSKRLRAE-GFEPVPHVAARSLADRAALDSFLGRLKDEAGVTQ 98 Query: 114 IVALRG--DLPPGSGKPEMYASDLVT--LLKEVADFDISVAAYPEVHPEAKSAQADLLNL 169 + + G D P G+ + DL+ L + I VA +PE P+ L Sbjct: 99 ALVVAGGLDRPVGA---FASSMDLLATGLFQAHGITRIGVAGHPEGTPDIPEPALK-DAL 154 Query: 170 KRKVDAGAN-----RAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA 224 K A TQF FD + + + G + I G ++ K KFA Sbjct: 155 LWKNRFAAEHGIDMYIETQFCFDAAAIIAWDRTIRGWGNRLPIHLGTPGLATLKTLLKFA 214 Query: 225 DMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILS-------REGVKDFHFYTL 277 + V + KL+ ++ L+ G++ HFY Sbjct: 215 QSSGVGPSIRVLTRQAR-----NLAKLLMVQAPDRLLVELAAYKASDPECGIEKLHFYPF 269 >UniRef50_D2S7Q5 Methylenetetrahydrofolate reductase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2S7Q5_9ACTO Length = 310 Score = 89.1 bits (220), Expect = 2e-16, Method: Composition-based stats. Identities = 54/292 (18%), Positives = 94/292 (32%), Gaps = 38/292 (13%) Query: 7 SQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE 66 R L ++L E S+E P R +E ++ + P V+VT Sbjct: 29 RSRGTLERALREA------SYEVLPLRGAEAS-----VVEHVPRTVPLTVTVTEAKGLT- 76 Query: 67 RDRTHSIIKGIKDRTGLEAAPHLTCID-ATPDELRTIARDYWNNGIRHIVALRGDLPPGS 125 T + + + G PHL L + + + + GD + Sbjct: 77 --PTLELAERL-SGHGFTVTPHLAARLVHDASHLADVIARLQAAAVDGVFVVGGDAAEPA 133 Query: 126 GKPEMYASDLVTLLKEVAD-F-DISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQ 183 G A L+ L+ V F + + YPE H + + L+RK A ITQ Sbjct: 134 GT-FPDALGLLEALETVGHHFRHVGIGGYPEGHGHISAELIE-RALERK-APHATHVITQ 190 Query: 184 FFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQM----- 238 F S + + G+D+ I G+ ++ + + + A Sbjct: 191 LCFHPASTTAWARQVKRRGVDLPIRIGLPGAVTRQKLIRISAGLGLGRSARFLAKQHSMF 250 Query: 239 ---FDGLDDDAETRKLVGANIAMDMVKILSR--EGVKDFHFYTLNRAEMSYA 285 F + + + L R ++ FHF+T N + A Sbjct: 251 WRFFLPHGYRPD-------RLVEGLAPTLGRPEHNLQGFHFFTFNEVARTEA 295 >UniRef50_B9KUP2 Methylenetetrahydrofolate reductase n=1 Tax=Rhodobacter sphaeroides KD131 RepID=B9KUP2_RHOSK Length = 279 Score = 88.3 bits (218), Expect = 3e-16, Method: Composition-based stats. Identities = 55/225 (24%), Positives = 84/225 (37%), Gaps = 20/225 (8%) Query: 71 HSIIKGIKDRTGLEAAPHLTCID-ATPDELRTIARDYWNNG-IRHIVALRGDLPPGSGKP 128 I GLE PHL + ++ D L + RD +R + GD SG P Sbjct: 55 LEAAAEI-RSAGLEPVPHLVARNLSSADALDAVLRDLRRMAQVRSVFVTGGDRDEPSG-P 112 Query: 129 EMYASDLVT--LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDA---GA--NRAI 181 A DL+ LL+ ++ A YPE HP +A + L+RK+ A G I Sbjct: 113 FASALDLLGTGLLQRHGLTRLAFAGYPEGHPRIPTADLE-EALRRKLAAARAGGFETLLI 171 Query: 182 TQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDG 241 +QF FD + R S G+ V + G ++ +FA A+ D Sbjct: 172 SQFAFDAAPVVAMARRLRSLGLMVPLRVGTAGPADRHTLAEFARDLGA---GHSAERLDH 228 Query: 242 LDDDAETRKLVGANIAMDMVKILSRE---GVKDFHFYTLNRAEMS 283 D + A + ++E G++ H + E S Sbjct: 229 PASDPAGFSIE--RFAAALADAQAQEPALGLEGLHLFPFGSTEAS 271 >UniRef50_B6BQ92 Methylenetetrahydrofolate reductase n=2 Tax=Bacteria RepID=B6BQ92_9RICK Length = 255 Score = 85.6 bits (211), Expect = 2e-15, Method: Composition-based stats. Identities = 45/263 (17%), Positives = 90/263 (34%), Gaps = 43/263 (16%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSV-TYGANSGERDRTHSIIKGIKDR 80 ++N S E P +T ++ L +K +V++ G D++ ++K Sbjct: 13 KMNFSLEIGP-KTD---------LETLPPVKDVYVTMLPGGDYKETSDQSIELVKK---- 58 Query: 81 TGLEAAPHLTCIDA-TPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLL 139 G PH EL+ + G++ + + G P + L+ Sbjct: 59 -GFNPVPHFPARSIENDSELKDYVSRCKDGGVKQALIIGGGREPMG--KFDSSFQLLE-T 114 Query: 140 KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199 + I +A +PE P+ D + +K A+ +TQ+ D + + F + Sbjct: 115 GYFENMKIGIAGHPEGSPDISDTDLDKAMMDKKPY--ADYIVTQWLLDPQPIIDFISK-- 170 Query: 200 SAGIDVEIIPGILPVSNFKQAKKFADMTNVR-----IPAWMAQMFDGLDDDAETRKLVGA 254 V + GI KFA++ + + + ++ D L Sbjct: 171 ---QSVPVHVGITGPLKISSLIKFANIVGAKNSLNFLKSNFSKALDLLKPKDPN------ 221 Query: 255 NIAMDMVKILSREGVKDFHFYTL 277 D++ + +FH YT Sbjct: 222 ----DLIGKVKSH-TDNFHIYTF 239 >UniRef50_B1L3C6 Methylenetetrahydrofolate reductase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3C6_KORCO Length = 226 Score = 85.2 bits (210), Expect = 2e-15, Method: Composition-based stats. Identities = 41/187 (21%), Positives = 70/187 (37%), Gaps = 21/187 (11%) Query: 28 EFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEAAP 87 E P + ++L + I F+S+ I+ + GLE P Sbjct: 6 EIVPSNLPKFLRSLSSVIG-----HANFISLPECPFGRPLPSPL-ILSVVAKGLGLEVIP 59 Query: 88 HLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVA-DFD 146 + +D + + GIR +V +RGDLP + + L+KE D + Sbjct: 60 NYRVMDRSELGFISEIMALSEVGIRRVVIVRGDLPSIGMPTSLNPVRAIELIKEHGIDIE 119 Query: 147 ISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVE 206 + VA Y + + L+ K++AGA+ +TQ DV D D+ Sbjct: 120 VGVATYTKPN----------EALRAKIEAGADFVVTQPIQDVGELSELLDFLG----DIP 165 Query: 207 IIPGILP 213 + I+P Sbjct: 166 LYTMIMP 172 >UniRef50_C9YXB3 Putative uncharacterized protein n=2 Tax=Actinomycetales RepID=C9YXB3_STRSW Length = 278 Score = 84.9 bits (209), Expect = 3e-15, Method: Composition-based stats. Identities = 41/255 (16%), Positives = 79/255 (30%), Gaps = 21/255 (8%) Query: 43 NSIDRLSSLKPKFVSVTYGANS-GERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDE-LR 100 + +++ + P+ V VT A+ + T + + G PH+ D L+ Sbjct: 22 ATEEKVLAHVPRDVVVTVTASPVKGLEPTLDLTGRLAA-HGYRVVPHVPARLLRDDRHLK 80 Query: 101 TIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVAD-FD-ISVAAYPEVHPE 158 + G+ + GD P +G + A ++ L E+ F + V YPE HP Sbjct: 81 EVVDRLREAGVDDVFVPAGDADPPAGPYDG-ALPVLRRLSELGGPFARVGVTGYPESHPL 139 Query: 159 AKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFK 218 + + K + A ++ FD + R + + + G+ Sbjct: 140 IHD-DVTVQAMWDKRE-HATYLVSNLCFDPRVLGEWLARVRRRDVTLPVHVGVAGPVQRA 197 Query: 219 QAKKFADMTNVRIP--------AWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVK 270 + A V +W + E + GV Sbjct: 198 KLLSMATKIGVGESTRFLTRHASWFVRFAAPGGYSPEKLLT-----RTEKALTDPASGVA 252 Query: 271 DFHFYTLNRAEMSYA 285 H +T N+ + Sbjct: 253 GLHLFTFNQIAETER 267 >UniRef50_C7JBE9 Methylenetetrahydrofolate reductase n=10 Tax=Acetobacteraceae RepID=C7JBE9_ACEP3 Length = 249 Score = 84.5 bits (208), Expect = 5e-15, Method: Composition-based stats. Identities = 38/219 (17%), Positives = 75/219 (34%), Gaps = 15/219 (6%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 +S E P + L + + + P ++ R+ ++ + G Sbjct: 5 RLSVELIP----RSAEALAADVATVKAAFPAADTLNIPDLMRFPLRSWDAAALVRPQFG- 59 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP-EMYASDLVTLLKEV 142 PH+ ID PD G+ I+ + GD P +++ + ++ Sbjct: 60 NVIPHIRAIDIAPDAP---LPGADQPGLEEILVVHGDPPADLSHRTYPNSTESI--IRRY 114 Query: 143 ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAG 202 + Y P ++ +L ++ RK +AGA TQ FD++ + D C Sbjct: 115 RREAPHLKVYAAFDPYRRAPWKELEDVARKKEAGAIGFFTQPVFDLKLF----DLCREWM 170 Query: 203 IDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDG 241 + G+ PV K + ++ P + D Sbjct: 171 QGECVFWGLSPVIGPKSRSYWETTNHIVFPRDFSPTLDA 209 >UniRef50_C8N7U0 Methylenetetrahydrofolate reductase n=1 Tax=Cardiobacterium hominis ATCC 15826 RepID=C8N7U0_9GAMM Length = 296 Score = 83.7 bits (206), Expect = 6e-15, Method: Composition-based stats. Identities = 41/248 (16%), Positives = 84/248 (33%), Gaps = 33/248 (13%) Query: 63 NSGERDRTHSIIKGIKDRTGLEAAPHLTCID-ATPDELRTIARDYWNNGIRHIVALRGDL 121 + + ++++ + A PH+ + + DELR GI I+ L G Sbjct: 46 RGTKISDCIDTCELLQNQ-HMCAVPHIVLRNYRSEDELRQTLDRVQALGIDRILLLAG-- 102 Query: 122 PPGSGKPEMYASDLVTLLK----EVADF-DISVAAYPEVHPEAKSAQADLLNLKRKVDAG 176 + +P ++++LK + F I A +PE + A + G Sbjct: 103 --AASQPLGPYDSVMSMLKTGLLQHYRFAHIGFAGHPEGAADIPRADQEAA---EAQKQG 157 Query: 177 ------ANR-AITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNV 229 + ITQF F + + + + I + + GI V++ + + A + Sbjct: 158 YALTYPGDYAFITQFCFQMPPIAAWLEHLQARQITLPVHIGIPGVASLQSLLRHAQACGI 217 Query: 230 RIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSRE-------GVKDFHFYTLNRAEM 282 + RKL+ + ++ L+ ++ HFY L E Sbjct: 218 GSSMSFL-----WKNARNVRKLMSLSTPDKLLCDLAAHRRDHPDSALRQLHFYPLGGFET 272 Query: 283 SYAICHTL 290 + + Sbjct: 273 TINWLRAI 280 >UniRef50_A9CIN8 Methylenetetrahydrofolate reductase n=2 Tax=Rhizobiales RepID=A9CIN8_AGRT5 Length = 306 Score = 83.7 bits (206), Expect = 7e-15, Method: Composition-based stats. Identities = 36/179 (20%), Positives = 74/179 (41%), Gaps = 16/179 (8%) Query: 62 ANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDA-TPDELRTIARDYW-NNGIRHIVALRG 119 + +++ +++ G E PHL + E + + ++ + G Sbjct: 51 TGAASQEKLVDAATHLRN-LGYEPVPHLAARRIPSRVEFEEQVKRLAGEADVTDVLVVGG 109 Query: 120 --DLPPGSGKPEMYASDLVT--LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDA 175 D P G P + D+++ + I++A +PE P+ S + + L+ K D Sbjct: 110 GVDRPAG---PFASSMDMLSSGIFDRYGIKKIAIAGHPEGSPD-FSEETAIAALRLKRDF 165 Query: 176 G-----ANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNV 229 G A R +TQF FD ++ + + ++GID+ + G+ + K+A + V Sbjct: 166 GERSDAAMRIVTQFGFDPARFIAWAEGLAASGIDLPVHIGVSGPAKITTLLKYAALCGV 224 >UniRef50_Q7VHW2 Methylenetetrahydrofolate reductase n=3 Tax=Helicobacter RepID=Q7VHW2_HELHP Length = 301 Score = 83.3 bits (205), Expect = 8e-15, Method: Composition-based stats. Identities = 41/295 (13%), Positives = 87/295 (29%), Gaps = 41/295 (13%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + +S E P + ++ L + L FV T + + + ++ Sbjct: 15 EPFLSVEIAPSISGRFDENLLEDLKTLKLAH-AFV-CTDSPLARFKPSSILSSLKFQNAL 72 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK------------PE 129 ++ D L G+R + L GD Sbjct: 73 QKPVICTISMRDRNSIALCGDILSVNELGLRTFLTLTGDSIKNGDCLQSKGVFEDNSLKL 132 Query: 130 MYASD------------LVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKV-DAG 176 + D L +K + +F + ++ A + + +++K+ Sbjct: 133 GHIIDELNCGRALNGKSLKENIKRIYNFQV-------INAYANNPLSLKNKMRKKLSSCE 185 Query: 177 ANRAITQFFFDVES----YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNVRI 231 + TQ + + + + I ++ G PV ++K A + V I Sbjct: 186 IHALFTQPVYSLNAAEFLLQSLEEIKSECNIKSALVLGFFPVLSYKTALFLRDKLPGVYI 245 Query: 232 PAWMAQMFDGLDDD-AETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYA 285 P Q + + + VG I+ + L FHF + N+ + Sbjct: 246 PNEWVQKLEKAHNKGKDEENKVGLEISHSLFMELKSVH-NKFHFMSANKPSLVKE 299 >UniRef50_Q1AXZ5 Methylenetetrahydrofolate reductase n=2 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1AXZ5_RUBXD Length = 324 Score = 82.6 bits (203), Expect = 1e-14, Method: Composition-based stats. Identities = 54/292 (18%), Positives = 95/292 (32%), Gaps = 35/292 (11%) Query: 27 FEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG---ERDRTHSIIKGIKDRTGL 83 +E P +E W R K +++T G T + + R G Sbjct: 16 YEVIPLAGTEEAVERWLISRRAEEQKKTTITITASPTRGIEPTIALTERLGAKARRRGGE 75 Query: 84 E----AAPHLTCIDA-TPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTL 138 PHL+ L I G+ + + GD G+ L L Sbjct: 76 PSSLCVVPHLSARLIEDEHHLEEIVARLKEAGVEEVFVIGGDAKEPRGRFHDALGLLEAL 135 Query: 139 LKEVADFD-ISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDR 197 + F+ + +A YPE HP + +A+L RK A+ ++Q F+ + L + R Sbjct: 136 EELGRPFERVGIAGYPEGHPSIE--RAELERALRKKALYASYVVSQLCFEAKKVLLWARR 193 Query: 198 CVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQM-----FDGLDDDAETRKLV 252 G+ + ++ G+ + K+ A + A + L R + Sbjct: 194 VRELGVGLPVVVGVAAPIDPKRLAGVAAKIGIGDSARFLRKQRAKSLLRLLSPGRRRSAL 253 Query: 253 GANI-----AMDMVKILSREG--------------VKDFHFYTLNRAEMSYA 285 ++V+ SREG + H YT N + + Sbjct: 254 SLVYEPGGFLEELVEEGSREGLLASSGGTEEGGGMISGLHLYTFNDLQRTLE 305 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_P71319 5,10-methylenetetrahydrofolate reductase n=247 T... 344 3e-93 UniRef50_B7VLL7 Methylenetetrahydrofolate reductase n=16 Tax=Pro... 332 9e-90 UniRef50_O67422 5,10-methylenetetrahydrofolate reductase n=9 Tax... 331 2e-89 UniRef50_Q9SE60 Methylenetetrahydrofolate reductase 1 n=8 Tax=Vi... 321 3e-86 UniRef50_B9HG95 Methylenetetrahydrofolate reductase n=6 Tax=rosi... 319 1e-85 UniRef50_Q0CXY7 Methylenetetrahydrofolate reductase n=18 Tax=Dik... 318 1e-85 UniRef50_B7G287 Methylenetetrahydrofolate reductase n=3 Tax=stra... 316 5e-85 UniRef50_O80585 Methylenetetrahydrofolate reductase 2 n=14 Tax=E... 316 7e-85 UniRef50_A6C2T8 Methylenetetrahydrofolate reductase n=1 Tax=Plan... 314 2e-84 UniRef50_C1ZF18 Methylenetetrahydrofolate reductase n=1 Tax=Plan... 311 2e-83 UniRef50_B2IJ01 Methylenetetrahydrofolate reductase n=5 Tax=Alph... 310 3e-83 UniRef50_B5JFK7 Methylenetetrahydrofolate reductase n=1 Tax=Verr... 309 6e-83 UniRef50_Q2ILB5 Methylenetetrahydrofolate reductase n=15 Tax=Bac... 306 7e-82 UniRef50_A8NEV2 Methylenetetrahydrofolate reductase n=2 Tax=Agar... 305 1e-81 UniRef50_Q3A3T2 Methylenetetrahydrofolate reductase n=20 Tax=Bac... 304 2e-81 UniRef50_B2UQZ6 Methylenetetrahydrofolate reductase n=3 Tax=Verr... 304 2e-81 UniRef50_B9XQY3 Methylenetetrahydrofolate reductase n=2 Tax=Verr... 304 3e-81 UniRef50_B9WCV3 Methylenetetrahydrofolate reductase n=10 Tax=Sac... 303 4e-81 UniRef50_P42898 Methylenetetrahydrofolate reductase n=58 Tax=Met... 302 1e-80 UniRef50_Q0AYF5 Methylenetetrahydrofolate reductase n=10 Tax=Bac... 301 1e-80 UniRef50_O54235 5,10-methylenetetrahydrofolate reductase n=40 Ta... 301 1e-80 UniRef50_Q3SVZ0 Methylenetetrahydrofolate reductase n=69 Tax=Pro... 301 3e-80 UniRef50_C1SKU9 Methylenetetrahydrofolate reductase n=1 Tax=Deni... 300 4e-80 UniRef50_B6FS52 Methylenetetrahydrofolate reductase n=1 Tax=Clos... 299 8e-80 UniRef50_C7LW31 Methylenetetrahydrofolate reductase n=2 Tax=Desu... 298 1e-79 UniRef50_A1WXM6 Methylenetetrahydrofolate reductase n=221 Tax=Ba... 298 2e-79 UniRef50_C5FI42 Methylenetetrahydrofolate reductase n=1 Tax=Micr... 298 2e-79 UniRef50_D1B7X9 Methylenetetrahydrofolate reductase n=1 Tax=Ther... 297 2e-79 UniRef50_Q21NJ7 Methylenetetrahydrofolate reductase n=2 Tax=Gamm... 297 3e-79 UniRef50_D1Y625 Methylenetetrahydrofolate reductase n=1 Tax=Pyra... 297 3e-79 UniRef50_Q04NW1 Methylenetetrahydrofolate reductase n=5 Tax=Lept... 297 3e-79 UniRef50_Q17693 Probable methylenetetrahydrofolate reductase n=5... 296 5e-79 UniRef50_C5RR04 Methylenetetrahydrofolate reductase n=1 Tax=Clos... 296 7e-79 UniRef50_C8V780 Methylenetetrahydrofolate reductase n=17 Tax=Leo... 295 1e-78 UniRef50_Q5KN82 Methylenetetrahydrofolate reductase n=1 Tax=Filo... 295 2e-78 UniRef50_P53128 Methylenetetrahydrofolate reductase 2 n=42 Tax=A... 295 2e-78 UniRef50_Q5FNV4 Methylenetetrahydrofolate reductase n=1 Tax=Gluc... 294 2e-78 UniRef50_A0LTK4 Methylenetetrahydrofolate reductase n=19 Tax=Act... 294 2e-78 UniRef50_A2QUJ5 Methylenetetrahydrofolate reductase n=16 Tax=Leo... 293 4e-78 UniRef50_B1L1W9 Methylenetetrahydrofolate reductase n=30 Tax=Bac... 293 5e-78 UniRef50_Q0AZY6 Methylenetetrahydrofolate reductase n=5 Tax=Clos... 292 1e-77 UniRef50_Q89B13 5,10-methylenetetrahydrofolate reductase n=74 Ta... 292 1e-77 UniRef50_B1ZNX1 Methylenetetrahydrofolate reductase n=2 Tax=Opit... 291 2e-77 UniRef50_D2QYY6 5,10-methylenetetrahydrofolate reductase n=3 Tax... 291 2e-77 UniRef50_A8XGR9 Methylenetetrahydrofolate reductase n=1 Tax=Caen... 290 3e-77 UniRef50_C4Y9Q4 Methylenetetrahydrofolate reductase n=1 Tax=Clav... 290 3e-77 UniRef50_A6TTI5 Methylenetetrahydrofolate reductase n=3 Tax=Clos... 290 5e-77 UniRef50_C5DIA7 Methylenetetrahydrofolate reductase n=2 Tax=Sacc... 290 5e-77 UniRef50_C6NUC2 Methylenetetrahydrofolate reductase n=1 Tax=Acid... 290 5e-77 UniRef50_C4R2L4 Methylenetetrahydrofolate reductase n=1 Tax=Pich... 288 2e-76 UniRef50_Q169G2 Methylenetetrahydrofolate reductase n=39 Tax=Rho... 287 2e-76 UniRef50_A8MFK9 Methylenetetrahydrofolate reductase n=7 Tax=Clos... 287 3e-76 UniRef50_UPI0001C36AF7 5,10-methylenetetrahydrofolate reductase ... 287 3e-76 UniRef50_D1ZNB9 Methylenetetrahydrofolate reductase n=1 Tax=Sord... 286 5e-76 UniRef50_C7N1R9 Methylenetetrahydrofolate reductase n=2 Tax=Cori... 286 5e-76 UniRef50_Q2HBA5 Methylenetetrahydrofolate reductase n=2 Tax=Leot... 286 5e-76 UniRef50_A1W0I6 Methylenetetrahydrofolate reductase n=14 Tax=Cam... 285 8e-76 UniRef50_C6PS47 Methylenetetrahydrofolate reductase n=1 Tax=Clos... 285 8e-76 UniRef50_P46151 Methylenetetrahydrofolate reductase 1 n=10 Tax=S... 285 9e-76 UniRef50_C4XPB4 Methylenetetrahydrofolate reductase n=11 Tax=Del... 285 9e-76 UniRef50_C9RM26 Methylenetetrahydrofolate reductase n=23 Tax=Bac... 285 1e-75 UniRef50_Q28TL9 Methylenetetrahydrofolate reductase n=3 Tax=Rhod... 284 2e-75 UniRef50_D0RN29 Methylenetetrahydrofolate reductase n=1 Tax=alph... 284 2e-75 UniRef50_Q30YC4 Methylenetetrahydrofolate reductase n=5 Tax=Desu... 284 3e-75 UniRef50_B3W8E2 Methylenetetrahydrofolate reductase n=15 Tax=Bac... 282 1e-74 UniRef50_Q6CEM7 Methylenetetrahydrofolate reductase n=1 Tax=Yarr... 282 1e-74 UniRef50_C0WB69 Methylenetetrahydrofolate reductase n=1 Tax=Acid... 281 2e-74 UniRef50_A9UZU5 Methylenetetrahydrofolate reductase n=1 Tax=Mono... 278 2e-73 UniRef50_A8ZV44 Methylenetetrahydrofolate reductase n=2 Tax=Desu... 278 2e-73 UniRef50_A4E8J9 Methylenetetrahydrofolate reductase n=1 Tax=Coll... 278 2e-73 UniRef50_Q0FF75 Methylenetetrahydrofolate reductase n=1 Tax=Rhod... 277 2e-73 UniRef50_C5L500 Methylenetetrahydrofolate reductase n=2 Tax=Perk... 277 4e-73 UniRef50_C0EZI4 Methylenetetrahydrofolate reductase n=1 Tax=Euba... 276 6e-73 UniRef50_B8BVS6 Methylenetetrahydrofolate reductase n=1 Tax=Thal... 276 6e-73 UniRef50_C8W5Z9 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 275 1e-72 UniRef50_C7NEN8 Methylenetetrahydrofolate reductase n=8 Tax=Fuso... 271 2e-71 UniRef50_A8PLM8 Methylenetetrahydrofolate reductase n=1 Tax=Rick... 269 1e-70 UniRef50_Q4P1E8 Methylenetetrahydrofolate reductase n=1 Tax=Usti... 268 1e-70 UniRef50_Q5M088 Methylenetetrahydrofolate reductase n=47 Tax=Fir... 268 2e-70 UniRef50_A6UBB8 Methylenetetrahydrofolate reductase n=45 Tax=Rhi... 267 3e-70 UniRef50_C4ZCX7 Methylenetetrahydrofolate reductase n=2 Tax=Firm... 267 3e-70 UniRef50_A5EYC8 Methylenetetrahydrofolate reductase n=2 Tax=Card... 267 4e-70 UniRef50_B7GRV7 Methylenetetrahydrofolate reductase n=16 Tax=Bif... 267 4e-70 UniRef50_Q4Q0B9 Methylenetetrahydrofolate reductase n=3 Tax=Leis... 265 1e-69 UniRef50_Q058D8 Methylenetetrahydrofolate reductase n=1 Tax=Buch... 264 4e-69 UniRef50_O74927 Methylenetetrahydrofolate reductase 2 n=2 Tax=Sc... 263 5e-69 UniRef50_C6BZ56 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 263 5e-69 UniRef50_C8NQ26 Methylenetetrahydrofolate reductase n=20 Tax=Cor... 262 9e-69 UniRef50_C9L8P5 Methylenetetrahydrofolate reductase n=1 Tax=Blau... 261 2e-68 UniRef50_B9Z0I7 Methylenetetrahydrofolate reductase n=1 Tax=Luti... 261 2e-68 UniRef50_B7GB47 Methylenetetrahydrofolate reductase (Fragment) n... 260 5e-68 UniRef50_D1U6W4 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 259 6e-68 UniRef50_B2A780 Methylenetetrahydrofolate reductase n=1 Tax=Natr... 257 5e-67 UniRef50_C2EUU9 Methylenetetrahydrofolate reductase n=2 Tax=Lact... 256 6e-67 UniRef50_C0QAY2 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 256 8e-67 UniRef50_A0JXH6 Methylenetetrahydrofolate reductase n=6 Tax=Micr... 255 1e-66 UniRef50_A8QAM7 Methylenetetrahydrofolate reductase n=1 Tax=Mala... 255 2e-66 UniRef50_D1PME0 Methylenetetrahydrofolate reductase n=1 Tax=Subd... 252 2e-65 UniRef50_C4R2Q6 Methylenetetrahydrofolate reductase n=6 Tax=Sacc... 250 4e-65 UniRef50_Q03V90 Methylenetetrahydrofolate reductase n=2 Tax=Leuc... 250 5e-65 UniRef50_A9BEZ6 Methylenetetrahydrofolate reductase n=2 Tax=Ther... 249 8e-65 UniRef50_D1BTF0 Methylenetetrahydrofolate reductase n=2 Tax=Acti... 249 1e-64 UniRef50_A7TTE9 Methylenetetrahydrofolate reductase n=2 Tax=Sacc... 244 2e-63 UniRef50_C3PE90 Methylenetetrahydrofolate reductase n=8 Tax=Cory... 244 3e-63 UniRef50_C7QYL7 Methylenetetrahydrofolate reductase n=2 Tax=Acti... 244 4e-63 UniRef50_Q2S0T1 Methylenetetrahydrofolate reductase n=4 Tax=cell... 243 5e-63 UniRef50_A6L1E2 Methylenetetrahydrofolate reductase n=45 Tax=Bac... 242 8e-63 UniRef50_B5Y6J3 Methylenetetrahydrofolate reductase n=2 Tax=Bact... 241 3e-62 UniRef50_D0JBB4 Methylenetetrahydrofolate reductase n=31 Tax=Bac... 240 4e-62 UniRef50_A3H552 Methylenetetrahydrofolate reductase (Fragment) n... 239 1e-61 UniRef50_D1BI58 Methylenetetrahydrofolate reductase n=2 Tax=Micr... 238 2e-61 UniRef50_C5BVR3 Methylenetetrahydrofolate reductase n=1 Tax=Beut... 232 8e-60 UniRef50_B2GHG1 Methylenetetrahydrofolate reductase n=1 Tax=Kocu... 232 8e-60 UniRef50_A8F6Y4 Methylenetetrahydrofolate reductase n=2 Tax=Ther... 232 1e-59 UniRef50_A4XIN5 Methylenetetrahydrofolate reductase n=1 Tax=Cald... 227 3e-58 UniRef50_A9B657 Methylenetetrahydrofolate reductase n=1 Tax=Herp... 227 4e-58 UniRef50_Q67LF9 Methylenetetrahydrofolate reductase n=1 Tax=Symb... 226 9e-58 UniRef50_B9L045 Methylenetetrahydrofolate reductase n=1 Tax=Ther... 225 9e-58 UniRef50_D1CBD0 Methylenetetrahydrofolate reductase n=1 Tax=Ther... 225 2e-57 UniRef50_A6W769 Methylenetetrahydrofolate reductase n=1 Tax=Kine... 224 3e-57 UniRef50_B9MN09 Methylenetetrahydrofolate reductase n=2 Tax=root... 223 5e-57 UniRef50_Q2LQ11 Methylenetetrahydrofolate reductase n=1 Tax=Synt... 221 3e-56 UniRef50_Q3M8T4 Methylenetetrahydrofolate reductase n=56 Tax=Cya... 220 4e-56 UniRef50_D0LSQ2 Methylenetetrahydrofolate reductase n=1 Tax=Hali... 219 8e-56 UniRef50_D0YUL0 Methylenetetrahydrofolate reductase n=1 Tax=Mobi... 219 1e-55 UniRef50_A8Q9P3 Methylenetetrahydrofolate reductase n=1 Tax=Mala... 218 1e-55 UniRef50_B0K6M8 Methylenetetrahydrofolate reductase n=14 Tax=Clo... 218 2e-55 UniRef50_C1F3L2 Methylenetetrahydrofolate reductase n=2 Tax=Bact... 218 2e-55 UniRef50_UPI00015B5A5C PREDICTED: hypothetical protein n=1 Tax=N... 217 3e-55 UniRef50_Q01QP4 Methylenetetrahydrofolate reductase n=2 Tax=Acid... 217 5e-55 UniRef50_B7AVK8 Methylenetetrahydrofolate reductase n=1 Tax=Bact... 215 2e-54 UniRef50_A8ZTK4 Methylenetetrahydrofolate reductase n=24 Tax=Bac... 214 2e-54 UniRef50_Q2RJ84 Methylenetetrahydrofolate reductase n=2 Tax=Bact... 211 3e-53 UniRef50_A9FZY9 Methylenetetrahydrofolate reductase n=1 Tax=Sora... 210 3e-53 UniRef50_C2KSD1 Methylenetetrahydrofolate reductase n=2 Tax=Mobi... 210 6e-53 UniRef50_C7M2P8 Methylenetetrahydrofolate reductase n=1 Tax=Acid... 209 7e-53 UniRef50_B5YJV3 Methylenetetrahydrofolate reductase n=1 Tax=Ther... 209 8e-53 UniRef50_D1N227 Methylenetetrahydrofolate reductase n=1 Tax=Vict... 209 1e-52 UniRef50_A7VPD0 Methylenetetrahydrofolate reductase n=1 Tax=Clos... 208 1e-52 UniRef50_A5ZMW8 Methylenetetrahydrofolate reductase n=4 Tax=Clos... 206 7e-52 UniRef50_B1HTR8 Methylenetetrahydrofolate reductase n=95 Tax=Bac... 206 8e-52 UniRef50_O06745 5,10-methylenetetrahydrofolate reductase n=78 Ta... 204 3e-51 UniRef50_Q8KTS2 Methylenetetrahydrofolate reductase n=1 Tax=Cand... 204 4e-51 UniRef50_A4J5C2 Methylenetetrahydrofolate reductase n=5 Tax=Clos... 203 5e-51 UniRef50_C6D4G9 Methylenetetrahydrofolate reductase n=12 Tax=cel... 203 7e-51 UniRef50_C6VPC5 Methylenetetrahydrofolate reductase n=3 Tax=Lact... 203 7e-51 UniRef50_A5UUW4 Methylenetetrahydrofolate reductase n=5 Tax=Chlo... 203 8e-51 UniRef50_A1AKP7 Methylenetetrahydrofolate reductase n=10 Tax=Des... 202 1e-50 UniRef50_B7RVE0 Methylenetetrahydrofolate reductase n=1 Tax=mari... 202 1e-50 UniRef50_Q12UZ6 Methylenetetrahydrofolate reductase n=4 Tax=Meth... 201 2e-50 UniRef50_B0VZI6 Methylenetetrahydrofolate reductase n=2 Tax=Culi... 201 3e-50 UniRef50_C4Z117 Methylenetetrahydrofolate reductase n=1 Tax=Euba... 200 4e-50 UniRef50_B9XKW8 Methylenetetrahydrofolate reductase n=1 Tax=bact... 200 6e-50 UniRef50_B8FFJ4 Methylenetetrahydrofolate reductase n=4 Tax=Bact... 198 1e-49 UniRef50_A8SCX4 Methylenetetrahydrofolate reductase n=3 Tax=Clos... 198 1e-49 UniRef50_A6W6I5 Methylenetetrahydrofolate reductase n=1 Tax=Kine... 198 2e-49 UniRef50_B0PF81 Methylenetetrahydrofolate reductase n=1 Tax=Anae... 197 3e-49 UniRef50_Q8DUN2 Methylenetetrahydrofolate reductase n=12 Tax=Str... 197 4e-49 UniRef50_A9QPD6 Methylenetetrahydrofolate reductase n=1 Tax=Meth... 196 7e-49 UniRef50_D0P2W8 Methylenetetrahydrofolate reductase n=1 Tax=Phyt... 196 7e-49 UniRef50_C4GEB4 Methylenetetrahydrofolate reductase n=1 Tax=Shut... 195 2e-48 UniRef50_A6UAD8 Methylenetetrahydrofolate reductase n=11 Tax=Pro... 194 3e-48 UniRef50_Q189R6 Methylenetetrahydrofolate reductase n=6 Tax=Clos... 194 3e-48 UniRef50_A7S5W8 Methylenetetrahydrofolate reductase n=1 Tax=Nema... 193 5e-48 UniRef50_C5RGW2 Methylenetetrahydrofolate reductase n=1 Tax=Clos... 193 7e-48 UniRef50_A3EWD2 Methylenetetrahydrofolate reductase n=2 Tax=Lept... 193 7e-48 UniRef50_B9JGE7 Methylenetetrahydrofolate reductase n=3 Tax=Rhiz... 192 1e-47 UniRef50_C8WWX3 Methylenetetrahydrofolate reductase n=2 Tax=Alic... 192 1e-47 UniRef50_B1GYU6 Methylenetetrahydrofolate reductase n=1 Tax=uncu... 192 2e-47 UniRef50_A8SPV0 Methylenetetrahydrofolate reductase n=2 Tax=Clos... 192 2e-47 UniRef50_C7LX76 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 192 2e-47 UniRef50_B7AQD9 Methylenetetrahydrofolate reductase n=1 Tax=Bact... 191 2e-47 UniRef50_B9DIA5 Methylenetetrahydrofolate reductase n=10 Tax=Sta... 190 7e-47 UniRef50_C0EVI7 Methylenetetrahydrofolate reductase n=1 Tax=Euba... 189 9e-47 UniRef50_C6HTS1 Methylenetetrahydrofolate reductase n=1 Tax=Lept... 189 1e-46 UniRef50_C0W5C3 Methylenetetrahydrofolate reductase n=1 Tax=Acti... 188 1e-46 UniRef50_B3TCN7 Methylenetetrahydrofolate reductase n=1 Tax=uncu... 188 2e-46 UniRef50_B8CZI6 Methylenetetrahydrofolate reductase n=1 Tax=Halo... 188 2e-46 UniRef50_Q39WH6 Methylenetetrahydrofolate reductase n=4 Tax=Geob... 188 2e-46 UniRef50_A5N923 Methylenetetrahydrofolate reductase n=2 Tax=Clos... 187 5e-46 UniRef50_B4LC84 Methylenetetrahydrofolate reductase n=3 Tax=Dros... 186 7e-46 UniRef50_A9BD12 Methylenetetrahydrofolate reductase n=2 Tax=Proc... 186 1e-45 UniRef50_Q1NSQ8 Methylenetetrahydrofolate reductase n=3 Tax=Delt... 185 2e-45 UniRef50_Q1AXR8 Methylenetetrahydrofolate reductase n=2 Tax=Bact... 184 4e-45 UniRef50_Q7M8S8 Methylenetetrahydrofolate reductase n=1 Tax=Woli... 183 4e-45 UniRef50_B8I637 Methylenetetrahydrofolate reductase n=2 Tax=Clos... 183 6e-45 UniRef50_Q2LZ54 Methylenetetrahydrofolate reductase n=1 Tax=Dros... 182 1e-44 UniRef50_B9L912 Methylenetetrahydrofolate reductase n=1 Tax=Naut... 177 3e-43 UniRef50_A6Q7Z1 Methylenetetrahydrofolate reductase n=4 Tax=Epsi... 176 1e-42 UniRef50_UPI0001BCEC92 bifunctional homocysteine S-methyltransfe... 174 3e-42 UniRef50_A6DEC7 Methylenetetrahydrofolate reductase n=1 Tax=Cami... 174 4e-42 UniRef50_C3XLP8 Methylenetetrahydrofolate reductase n=1 Tax=Heli... 172 1e-41 UniRef50_B2K1S3 Methylenetetrahydrofolate reductase n=22 Tax=Yer... 172 2e-41 UniRef50_B2Q6I6 Methylenetetrahydrofolate reductase n=1 Tax=Prov... 169 1e-40 UniRef50_Q9VTI0 Methylenetetrahydrofolate reductase n=6 Tax=mela... 168 2e-40 UniRef50_B8FJ30 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 166 7e-40 UniRef50_B4MKM9 Methylenetetrahydrofolate reductase n=1 Tax=Dros... 165 2e-39 UniRef50_C0QIT4 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 164 4e-39 UniRef50_B5YA71 Methylenetetrahydrofolate reductase n=2 Tax=Dict... 163 6e-39 UniRef50_C0QE80 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 163 7e-39 UniRef50_C8R0R0 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 161 4e-38 UniRef50_Q64DN7 5-10-methylenetetrahydrofolate reductase n=3 Tax... 160 8e-38 UniRef50_Q5TWY6 Methylenetetrahydrofolate reductase n=1 Tax=Anop... 159 1e-37 UniRef50_C5F201 Methylenetetrahydrofolate reductase n=2 Tax=Heli... 159 1e-37 UniRef50_A9G9E1 Methylenetetrahydrofolate reductase n=1 Tax=Sora... 156 8e-37 UniRef50_D1B0C6 Methylenetetrahydrofolate reductase n=1 Tax=Sulf... 155 1e-36 UniRef50_B9KC45 Methylenetetrahydrofolate reductase n=6 Tax=Ther... 155 2e-36 UniRef50_Q9HJI8 5, 10-methylenetetrahydrofolate reductase relate... 153 5e-36 UniRef50_C7MZV4 Methylenetetrahydrofolate reductase n=1 Tax=Sacc... 151 3e-35 UniRef50_Q9EYI8 Methylenetetrahydrofolate reductase n=2 Tax=Acti... 150 5e-35 UniRef50_A7HND8 Methylenetetrahydrofolate reductase n=1 Tax=Ferv... 150 9e-35 UniRef50_C0QY90 Methylenetetrahydrofolate reductase n=2 Tax=Brac... 149 1e-34 UniRef50_A8A9S7 Methylenetetrahydrofolate reductase n=1 Tax=Igni... 147 3e-34 UniRef50_Q251W5 Methylenetetrahydrofolate reductase n=3 Tax=Bact... 146 6e-34 UniRef50_B1ZRF7 Methylenetetrahydrofolate reductase n=2 Tax=Verr... 146 1e-33 UniRef50_Q60FX0 Methylenetetrahydrofolate reductase n=1 Tax=Sphi... 145 2e-33 UniRef50_B0TCJ7 Methylenetetrahydrofolate reductase n=6 Tax=Bact... 142 1e-32 UniRef50_C4DNM1 Methylenetetrahydrofolate reductase n=1 Tax=Stac... 141 2e-32 UniRef50_D0XP42 Methylenetetrahydrofolate reductase n=1 Tax=Brev... 141 2e-32 UniRef50_Q18JC7 5,10-methylenetetrahydrofolate reductase n=2 Tax... 140 5e-32 UniRef50_Q7VHW2 Methylenetetrahydrofolate reductase n=3 Tax=Heli... 140 8e-32 UniRef50_A4FL79 Methylenetetrahydrofolate reductase n=1 Tax=Sacc... 136 1e-30 UniRef50_A5EXW9 Methylenetetrahydrofolate reductase n=1 Tax=Dich... 136 1e-30 UniRef50_Q2G4C7 Methylenetetrahydrofolate reductase n=1 Tax=Novo... 134 2e-30 UniRef50_A8TJJ1 MetFprotein-like protein n=2 Tax=Bacteria RepID=... 134 3e-30 UniRef50_C9KNQ4 Methylenetetrahydrofolate reductase n=1 Tax=Mits... 134 3e-30 UniRef50_B6A4H7 Methylenetetrahydrofolate reductase n=2 Tax=Rhiz... 133 8e-30 UniRef50_B9KZH8 Methylenetetrahydrofolate reductase n=2 Tax=Ther... 133 8e-30 UniRef50_C0QKT3 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 132 2e-29 UniRef50_Q05FX5 Methylenetetrahydrofolate reductase n=1 Tax=Cand... 132 2e-29 UniRef50_C7MDX6 Methylenetetrahydrofolate reductase n=1 Tax=Brac... 131 2e-29 UniRef50_A0L7S2 Methylenetetrahydrofolate reductase n=2 Tax=cell... 131 2e-29 UniRef50_Q3BYU2 Methylenetetrahydrofolate reductase n=16 Tax=cel... 131 3e-29 UniRef50_A6EV92 Methylenetetrahydrofolate reductase n=1 Tax=Mari... 131 3e-29 UniRef50_B8FFI9 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 129 9e-29 UniRef50_UPI0001C31E0D methylenetetrahydrofolate reductase n=1 T... 129 1e-28 UniRef50_A0JQZ4 Methylenetetrahydrofolate reductase n=1 Tax=Arth... 126 1e-27 UniRef50_A6DQ26 Methylenetetrahydrofolate reductase n=1 Tax=Lent... 126 1e-27 UniRef50_D2S7Q5 Methylenetetrahydrofolate reductase n=1 Tax=Geod... 125 2e-27 UniRef50_B6BQ92 Methylenetetrahydrofolate reductase n=2 Tax=Bact... 125 2e-27 UniRef50_B0VPR6 Methylenetetrahydrofolate reductase n=15 Tax=Aci... 124 4e-27 UniRef50_A4TRX0 Methylenetetrahydrofolate reductase n=1 Tax=Yers... 124 5e-27 UniRef50_C8N7U0 Methylenetetrahydrofolate reductase n=1 Tax=Card... 123 1e-26 UniRef50_C9YXB3 Putative uncharacterized protein n=2 Tax=Actinom... 121 2e-26 UniRef50_C7JBE9 Methylenetetrahydrofolate reductase n=10 Tax=Ace... 121 4e-26 UniRef50_A6DQ44 Methylenetetrahydrofolate reductase n=1 Tax=Lent... 120 7e-26 UniRef50_A6VT58 Methylenetetrahydrofolate reductase n=1 Tax=Mari... 118 3e-25 UniRef50_Q4W2U7 Methylenetetrahydrofolate reductase n=1 Tax=Rhod... 117 6e-25 UniRef50_Q1AXZ5 Methylenetetrahydrofolate reductase n=2 Tax=Rubr... 116 6e-25 UniRef50_Q92XS4 Methylenetetrahydrofolate reductase n=2 Tax=Rhiz... 116 8e-25 Sequences not found previously or not previously below threshold: >UniRef50_P71319 5,10-methylenetetrahydrofolate reductase n=247 Tax=Proteobacteria RepID=METF_PECCC Length = 298 Score = 344 bits (882), Expect = 3e-93, Method: Composition-based stats. Identities = 252/296 (85%), Positives = 279/296 (94%) Query: 1 MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY 60 MSFFHA+QR+ALNQSLAE+QG+INVSFEFFPPRTS+ME+TLW+SIDRLSSLKPKFVSVTY Sbjct: 1 MSFFHANQREALNQSLAELQGRINVSFEFFPPRTSDMEETLWSSIDRLSSLKPKFVSVTY 60 Query: 61 GANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD 120 GANSGERDRTHSIIK IK+RTGLEAAPHLTCIDA+ ++LR IA+DYW +GIRHIVALRGD Sbjct: 61 GANSGERDRTHSIIKTIKERTGLEAAPHLTCIDASREQLREIAQDYWESGIRHIVALRGD 120 Query: 121 LPPGSGKPEMYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRA 180 LP GKP+MYA+DLV+LLKEV DFDISVAAYPEVHPEAKSAQADL+NLK K+DAGANRA Sbjct: 121 LPQEGGKPDMYAADLVSLLKEVGDFDISVAAYPEVHPEAKSAQADLINLKHKIDAGANRA 180 Query: 181 ITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFD 240 ITQFFFDVESYLRFRDRCV+ GIDVEI+PGILPVSNFKQ +KFA MTNVR+P WM MFD Sbjct: 181 ITQFFFDVESYLRFRDRCVATGIDVEIVPGILPVSNFKQLQKFATMTNVRVPNWMTTMFD 240 Query: 241 GLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 GLD+D ETRK+VGA+IAMDMVKILSREGVKDFHFYTLNRAE+SYAICHTLGVRP + Sbjct: 241 GLDNDPETRKMVGASIAMDMVKILSREGVKDFHFYTLNRAELSYAICHTLGVRPDV 296 >UniRef50_B7VLL7 Methylenetetrahydrofolate reductase n=16 Tax=Proteobacteria RepID=B7VLL7_VIBSL Length = 337 Score = 332 bits (852), Expect = 9e-90, Method: Composition-based stats. Identities = 225/296 (76%), Positives = 259/296 (87%) Query: 1 MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY 60 M + HAS DALNQ++AE+ INVSFEFFPP + +ME+TLWNS+ RL +L+PKFVSVTY Sbjct: 39 MGYTHASHIDALNQNIAELSDNINVSFEFFPPSSEKMEETLWNSVHRLKTLQPKFVSVTY 98 Query: 61 GANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD 120 GANSGERDRTHSIIK IK++TGL AAPHLTCIDA+ +EL IA DYW NGI IVALRGD Sbjct: 99 GANSGERDRTHSIIKEIKNQTGLVAAPHLTCIDASREELIQIADDYWANGIESIVALRGD 158 Query: 121 LPPGSGKPEMYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRA 180 +P G G P+MYASDLV LLK DFDISVAA+PEVHPEAKSAQ+DL+NLKRKVDAGANRA Sbjct: 159 IPAGGGAPDMYASDLVELLKSRHDFDISVAAFPEVHPEAKSAQSDLINLKRKVDAGANRA 218 Query: 181 ITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFD 240 ITQFFFDVESYLRFRDRCV+AG+DVEI+PGILPVSNFKQA +FA M NV++P WMA+ F+ Sbjct: 219 ITQFFFDVESYLRFRDRCVAAGVDVEIVPGILPVSNFKQASRFAAMNNVKVPGWMAKQFE 278 Query: 241 GLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 GLDDD TR+LVGA+ A+DMV+ LSREGVKDFHFYTLNRAEM+YA+CHTLGVRP + Sbjct: 279 GLDDDPTTRQLVGASQAIDMVRTLSREGVKDFHFYTLNRAEMTYALCHTLGVRPQV 334 >UniRef50_O67422 5,10-methylenetetrahydrofolate reductase n=9 Tax=Bacteria RepID=METF_AQUAE Length = 296 Score = 331 bits (848), Expect = 2e-89, Method: Composition-based stats. Identities = 117/281 (41%), Positives = 169/281 (60%), Gaps = 8/281 (2%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 +G ++SFEFFPP+T E E+ L+ +I +L L P FVSVTYGA RDRT +I++ I Sbjct: 8 RKGVFSISFEFFPPKTEEGERQLFETIRKLEKLNPTFVSVTYGAGGSTRDRTRNIVQKIH 67 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM------YA 132 + T L HLTCI T +EL I +DY N GI +I+ALRGD+P YA Sbjct: 68 EETNLTVMAHLTCIAHTREELIDILQDYKNIGIENILALRGDVPRDKPDWRPPKGACKYA 127 Query: 133 SDLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES 190 +LV L+++ F I VA+YPE HPE+ + + ++ K KV+AGA+ +ITQ FF + Sbjct: 128 KELVELIRKEFGDWFSIGVASYPEGHPESPNLEWEVKYFKEKVEAGADFSITQMFFVNDY 187 Query: 191 YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRK 250 Y RF + C +AGID+ IIPGI+P++NFKQ +KFA + IP + + + ++D E K Sbjct: 188 YYRFVEMCKNAGIDISIIPGIMPITNFKQIRKFASLCGATIPQSLIEKLEKVEDKPEEVK 247 Query: 251 LVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 +G A++ L GV HFYTLN+++ + I + Sbjct: 248 KIGIEFAINQCLDLIEHGVPGLHFYTLNKSDATLKIYEAIK 288 >UniRef50_Q9SE60 Methylenetetrahydrofolate reductase 1 n=8 Tax=Viridiplantae RepID=MTHR1_ARATH Length = 592 Score = 321 bits (822), Expect = 3e-86, Method: Composition-based stats. Identities = 102/297 (34%), Positives = 154/297 (51%), Gaps = 17/297 (5%) Query: 15 SLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSII 74 QGQ SFEFFPP+T + + L+ +DRL S P F +T+GA D T I Sbjct: 8 KSVTEQGQTAFSFEFFPPKTEDGVENLFERMDRLVSYGPTFCDITWGAGGSTADLTLEIA 67 Query: 75 KGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------ 128 +++ +E HLTC + +++ +NGI++++ALRGD P G K Sbjct: 68 SRMQNVICVETMMHLTCTNMPIEKIDHALETIRSNGIQNVLALRGDPPHGQDKFVQVEGG 127 Query: 129 EMYASDLVTLLKEVAD--FDISVAAYPEVHPEA---------KSAQADLLNLKRKVDAGA 177 A DLV ++ F I+VA YPE HP+ +S Q+DL LK+KVDAGA Sbjct: 128 FACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEADGLATPESYQSDLAYLKKKVDAGA 187 Query: 178 NRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQ 237 + +TQ F+D + +L+F + C GI+ I+PGI+P+SN+K + A +IPA + Sbjct: 188 DLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCKTKIPAELTA 247 Query: 238 MFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRP 294 + + D+ E K G + A +M K + G+ H YTLN + + I LG+ Sbjct: 248 ALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDKSAIGILMNLGLID 304 >UniRef50_B9HG95 Methylenetetrahydrofolate reductase n=6 Tax=rosids RepID=B9HG95_POPTR Length = 608 Score = 319 bits (817), Expect = 1e-85, Method: Composition-based stats. Identities = 95/291 (32%), Positives = 151/291 (51%), Gaps = 17/291 (5%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 ++ SFEFFPP+T + L+ +DR+ + P F +T+GA D T I +++ Sbjct: 27 SNKVVFSFEFFPPKTEDGVDNLFERMDRMVAHNPSFCDITWGAGGSTADLTLDIANKMQN 86 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYAS 133 +E HLTC + +++ +NGI++++ALRGD P G K A Sbjct: 87 IICVETMMHLTCTNMPVEKIDHALETIKSNGIQNVLALRGDPPHGQDKFVQIQGGFACAL 146 Query: 134 DLVTLLKEVAD--FDISVAAYPEVHPEA---------KSAQADLLNLKRKVDAGANRAIT 182 DLV ++ F I+VA YPE HP+A + Q DL LK+KVDAGA+ +T Sbjct: 147 DLVKHIRSKYGDYFGITVAGYPEAHPDAIGSDGFATPEDYQKDLAYLKQKVDAGADLIVT 206 Query: 183 QFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGL 242 Q F+D + +L+F + C GI I+PGI+P++N+K + +IPA + + + Sbjct: 207 QLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCKTKIPAEVTAALEPI 266 Query: 243 DDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 D+ E + G ++ +M K + G+K H YTLN + + AI LG+ Sbjct: 267 KDNEEAVRAYGIHLGTEMCKKILAHGIKTLHLYTLNMEKSALAILMNLGLI 317 >UniRef50_Q0CXY7 Methylenetetrahydrofolate reductase n=18 Tax=Dikarya RepID=Q0CXY7_ASPTN Length = 619 Score = 318 bits (816), Expect = 1e-85, Method: Composition-based stats. Identities = 97/300 (32%), Positives = 159/300 (53%), Gaps = 12/300 (4%) Query: 4 FHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN 63 H S++ A N E G+ +SFEFFPP+T++ Q L++ +DR+ +L P F+ +T+GA Sbjct: 1 MHISEKLAQN----EAAGRPGISFEFFPPKTAQGVQNLYDRMDRMHALGPSFIDITWGAG 56 Query: 64 SGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP 123 D T ++ + GLE HLTC D +++ + + G +I+ALRGD P Sbjct: 57 GRLSDLTCEMVNVAQSVYGLETCMHLTCTDMPLEKVDAALQSAYKAGCTNILALRGDPPR 116 Query: 124 GSGKPEM------YASDLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDA 175 K E YA DLV +++ FDI V YPE + + +LK KVDA Sbjct: 117 EKEKWEATDGGFRYAKDLVKYIRDKYGNHFDIGVGGYPEGADDNPDVDLLIDHLKEKVDA 176 Query: 176 GANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWM 235 G++ +TQ F+D ++++ + +C + GI+V IIPGI+P+ + + A+ T +RIP Sbjct: 177 GSSFIVTQMFYDTDNFINWVKKCRAKGINVPIIPGIMPIQTYAAFMRRANWTKIRIPPEW 236 Query: 236 AQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPG 295 + + + +D K +G + DM + L G+ HFYT+N A+ + + L + P Sbjct: 237 LEALEPVKNDDAAVKEIGKGLIADMCRRLLAAGINHLHFYTMNLAQSTQLVLEELNLTPS 296 >UniRef50_B7G287 Methylenetetrahydrofolate reductase n=3 Tax=stramenopiles RepID=B7G287_PHATR Length = 634 Score = 316 bits (811), Expect = 5e-85, Method: Composition-based stats. Identities = 95/304 (31%), Positives = 149/304 (49%), Gaps = 21/304 (6%) Query: 7 SQRDALNQSLAEVQ-----GQINVSFEFFPPRTSEMEQTLWNSIDRLS-SLKPKFVSVTY 60 D+ SL + Q G SFEFFPP+T L IDR++ L P F+ VT+ Sbjct: 18 RSNDSRQPSLHDCQLNFPGGNWYYSFEFFPPKTEAGLDNLLTRIDRMAQRLDPLFIDVTW 77 Query: 61 GANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD 120 G++ RT ++ + G++ HL+C T D+L + GI +I+ALRGD Sbjct: 78 GSD-KTSARTMALASHAQKYLGVDVLLHLSCQGMTRDQLIRVLDQAKVLGIHNILALRGD 136 Query: 121 LPPGSGKPEM---------YASDLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNL 169 P ++ A DLV L++ F I+VA +PE HP + S + +L +L Sbjct: 137 PPKAKKHWQVGDVSGGECERAIDLVRLIRNTYGDYFGIAVAGHPEGHPSSTSPEDELDHL 196 Query: 170 KRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNV 229 K K+ AGA+ I+QF +D E +L F RC GI I+PGI+P+ ++ + V Sbjct: 197 KEKMRAGADFIISQFVYDTERFLDFCYRCRDVGIQCPILPGIMPIQSYSSFTRMTQYCGV 256 Query: 230 RIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREG---VKDFHFYTLNRAEMSYAI 286 +P + + + + DD E K +G ++A +M + + + + HFYTLN + I Sbjct: 257 SVPDEIWKRLEPIKDDDEAVKEIGCSLAAEMCRQILADPIAKIDGVHFYTLNLERSATRI 316 Query: 287 CHTL 290 L Sbjct: 317 LMQL 320 >UniRef50_O80585 Methylenetetrahydrofolate reductase 2 n=14 Tax=Eukaryota RepID=MTHR2_ARATH Length = 594 Score = 316 bits (809), Expect = 7e-85, Method: Composition-based stats. Identities = 98/298 (32%), Positives = 158/298 (53%), Gaps = 18/298 (6%) Query: 14 QSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSI 73 QSLA+ +G+ SFEFFPP+T + L+ +DR+ + P F +T+GA D T I Sbjct: 8 QSLAD-EGKTAFSFEFFPPKTEDGVDNLFERMDRMVAYGPTFCDITWGAGGSTADLTLDI 66 Query: 74 IKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP----- 128 +++ +E+ HLTC + +++ +NGI++++ALRGD P G K Sbjct: 67 ASRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQDKFVQVEG 126 Query: 129 -EMYASDLVTLLKEVAD--FDISVAAYPEVHPEA---------KSAQADLLNLKRKVDAG 176 A DLV ++ F I+VA YPE HP+ ++ Q+DL LK+K+DAG Sbjct: 127 GFDCALDLVNHIRSKYGDYFGITVAGYPEAHPDVIGENGLASNEAYQSDLEYLKKKIDAG 186 Query: 177 ANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMA 236 A+ +TQ F+D + +L+F + C GI I+PGI+P++N++ + +IP + Sbjct: 187 ADLIVTQLFYDTDIFLKFVNDCRQIGISCPIVPGIMPINNYRGFLRMTGFCKTKIPVEVM 246 Query: 237 QMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRP 294 + + D+ E K G ++ +M K + GVK H YTLN + + AI LG+ Sbjct: 247 AALEPIKDNEEAVKAYGIHLGTEMCKKMLAHGVKSLHLYTLNMEKSALAILMNLGMID 304 >UniRef50_A6C2T8 Methylenetetrahydrofolate reductase n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C2T8_9PLAN Length = 297 Score = 314 bits (806), Expect = 2e-84, Method: Composition-based stats. Identities = 105/278 (37%), Positives = 157/278 (56%), Gaps = 7/278 (2%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 G +S E FPPR + L+ +++ L +P FVS TYGA RT + I+++ Sbjct: 10 GTFGLSVEIFPPRNESGDAELFKTLEELVRYQPAFVSCTYGAGGSTSKRTIELCALIQNQ 69 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYASD 134 A H TC+++T +EL ++ + GI +I+ALRGD P G YA++ Sbjct: 70 LHNTATAHFTCVNSTREELVEWLQNAVDAGITNIMALRGDPPAGQETFVPADGGLKYANE 129 Query: 135 LVTLLKE-VADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLR 193 LV+L+++ D I VA YPE HPEA A+ DL NLKRKVDAGA+ TQ FF+ E + + Sbjct: 130 LVSLIRKHFPDMGIGVAGYPECHPEASDAEVDLTNLKRKVDAGADAIYTQLFFNNEHFYQ 189 Query: 194 FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVG 253 FR+RC+ AGID I+PGI+P++ +++ ++ M + PA + + DD E + +G Sbjct: 190 FRERCLKAGIDRPIVPGIMPITEYRRIQRIMSMCSSEFPADLVGQLEAAQDDLEAQFEIG 249 Query: 254 ANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 A+ + L +EGV HFY LNR++ I LG Sbjct: 250 VEYAIRQCEQLIKEGVPGIHFYVLNRSQACKRIFDALG 287 >UniRef50_C1ZF18 Methylenetetrahydrofolate reductase n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZF18_PLALI Length = 310 Score = 311 bits (797), Expect = 2e-83, Method: Composition-based stats. Identities = 97/284 (34%), Positives = 152/284 (53%), Gaps = 9/284 (3%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 GQ +S E FPP+T+E + L ++ S+ P FVS TYGA R RT + I Sbjct: 20 ASGQFALSIEIFPPKTAEGDAALRQALQEFSTYNPAFVSCTYGAGGSTRSRTLDWCREII 79 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYA 132 DR G+ H TC+ + DEL W G+R+I+ALRGD+P G + +A Sbjct: 80 DRVGVAPTAHFTCVGSNSDELIDWLGQAWQLGVRNIMALRGDVPQGETEFKAVEGGFSHA 139 Query: 133 SDLVTLLK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESY 191 LV L++ E + I VA YPE HPEA S + D+ LK K+ G + TQ F+D E++ Sbjct: 140 RQLVELIRKEFPEMGIGVAGYPEKHPEAVSLETDIAFLKEKITVGGHAVFTQLFYDNETF 199 Query: 192 LRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLD--DDAETR 249 R+ + C+ GID IIPG++P++ + + K+ +++ ++PA + + + DD + Sbjct: 200 YRYWEMCLKQGIDAPIIPGVMPITEYSRVKRIVEISGTKVPAELLEQLEAAHLRDDKAAQ 259 Query: 250 KLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 +G ++ + L GV HFY LN+A + I +LG++ Sbjct: 260 LEIGIEYSVQQCQDLIDHGVPGLHFYVLNKAHATSQILQSLGLK 303 >UniRef50_B2IJ01 Methylenetetrahydrofolate reductase n=5 Tax=Alphaproteobacteria RepID=B2IJ01_BEII9 Length = 309 Score = 310 bits (795), Expect = 3e-83, Method: Composition-based stats. Identities = 147/301 (48%), Positives = 203/301 (67%), Gaps = 7/301 (2%) Query: 3 FFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGA 62 D+ ++ ++VSFEFFPP+T ME TLW SI+RL+ L+P FVSVTYGA Sbjct: 4 TMTLQSIDSSPRASRGTCEGMSVSFEFFPPKTEAMEATLWESINRLAPLQPSFVSVTYGA 63 Query: 63 NSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP 122 R+RTH+ + I T ++ A HLTC+ A+ E+ +A+ YW G+RHIVALRGD Sbjct: 64 GGSTRERTHATVARIVKETPIKPAAHLTCVAASCAEVDAVAKAYWEAGVRHIVALRGDPL 123 Query: 123 PGSG-------KPEMYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDA 175 G G + +++DLV L+++ADF+ISV+AYPE HPE+ S ++DL L+ K+DA Sbjct: 124 EGIGTAFHPHPQGYAHSTDLVAGLRKIADFEISVSAYPEKHPESASIESDLDVLQAKIDA 183 Query: 176 GANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWM 235 GA RAITQFFF+ ++YLR+ D+ + GI + I+PGI+PV NFKQ FA IP W+ Sbjct: 184 GATRAITQFFFENDTYLRYLDKVRARGITIPILPGIVPVQNFKQTANFAKKAGASIPPWL 243 Query: 236 AQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPG 295 A+ F+GLDDD +TR+L+ A +A + V L GV+DFHFYT+NRA++ YAICH LG+RP Sbjct: 244 AERFEGLDDDPQTRRLIAATVAAEQVLDLVDRGVRDFHFYTMNRADLVYAICHLLGLRPK 303 Query: 296 L 296 L Sbjct: 304 L 304 >UniRef50_B5JFK7 Methylenetetrahydrofolate reductase n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JFK7_9BACT Length = 296 Score = 309 bits (793), Expect = 6e-83, Method: Composition-based stats. Identities = 102/276 (36%), Positives = 148/276 (53%), Gaps = 7/276 (2%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 + +S EFFPP++ E L S + L+ P FVSVTYGA RDR+ + ++D Sbjct: 13 SRPLLSVEFFPPKSDEALDELVESAEELAPYSPDFVSVTYGAGGSTRDRSAKACQLLRDE 72 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYASD 134 PHLTC+ A+ EL + G R+I+ALRGD P S +ASD Sbjct: 73 HDFNIMPHLTCVGASRGELAETINGLYEAGYRNIMALRGDPPKDSNSFVVAKDGFAHASD 132 Query: 135 LVTLLKEVA-DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLR 193 LV+ +KE+ D I VA YPE HPEA DL +LK KVDAGA+ TQ FFD R Sbjct: 133 LVSFIKELHPDISIGVAGYPEKHPEATDLATDLRHLKTKVDAGASFITTQLFFDNADLYR 192 Query: 194 FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVG 253 F D+ GI+V +IPG++PV + KQ K+ A + +P+ + + D+AE + +G Sbjct: 193 FLDQAADQGIEVPVIPGLMPVLSIKQIKRIASLCGASLPSELETHLNAAGDNAELVRQIG 252 Query: 254 ANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHT 289 A + ++ L +G+ H Y LNR++++ + Sbjct: 253 VRWASEQLQDLVEQGLPGVHLYALNRSDIATELMSA 288 >UniRef50_Q2ILB5 Methylenetetrahydrofolate reductase n=15 Tax=Bacteria RepID=Q2ILB5_ANADE Length = 300 Score = 306 bits (783), Expect = 7e-82, Method: Composition-based stats. Identities = 100/285 (35%), Positives = 155/285 (54%), Gaps = 9/285 (3%) Query: 15 SLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSII 74 A +G+ SFEFFPP+T + + L+ +++ L L P +VSVTYGA R +T ++ Sbjct: 8 RFARERGEPIFSFEFFPPKTDDGVRGLFETVEALRPLGPAYVSVTYGAGGSTRAKTIDLV 67 Query: 75 KGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------ 128 K +K +EA H+TC+ A+ +E+ + + + GI++++ALRGD P G Sbjct: 68 KRLKRDAEVEAMAHVTCVGASREEIAAVLDEVADAGIQNVLALRGDAPRGQSAFVPHPDG 127 Query: 129 EMYASDLVTLLK---EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFF 185 +AS+LV ++ E F + AAYPE H E + DL NLK KV+AG + +TQ F Sbjct: 128 FTHASELVAFIRSRPERWRFCVGAAAYPEGHVETRDLAQDLRNLKLKVEAGTDFLVTQLF 187 Query: 186 FDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDD 245 F+ Y RF +R +AG++V ++PGI+P +N +Q ++F M IP + + D Sbjct: 188 FENAHYFRFVERARAAGVEVPVVPGIMPFTNVEQVERFTAMCGAAIPPPLRAAMEVRRAD 247 Query: 246 AETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + + +G A L R G HFYTLNR+ + AI L Sbjct: 248 PDGARELGVAYATLQCADLLRRGAPGIHFYTLNRSPSTRAIVAAL 292 >UniRef50_A8NEV2 Methylenetetrahydrofolate reductase n=2 Tax=Agaricales RepID=A8NEV2_COPC7 Length = 617 Score = 305 bits (782), Expect = 1e-81, Method: Composition-based stats. Identities = 92/299 (30%), Positives = 151/299 (50%), Gaps = 16/299 (5%) Query: 11 ALNQSLAE-VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDR 69 L+Q +AE + +FEFFPPRT + + L I RLS+L P +S+T+GA ++R Sbjct: 2 KLSQKIAEHDPSKPFYTFEFFPPRTDQGTENLIARISRLSTLDPLAISITWGAGGSTKER 61 Query: 70 THSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP- 128 + + + + L+ HLTC + + + +D + GI I+ALRGD P G + Sbjct: 62 SLDLASITQSQHRLDTILHLTCTNMEQGLIDDVLKDVKDRGIETILALRGDPPRGEEEWI 121 Query: 129 -----EMYASDLVTLLKEVA----DFDISVAAYPEVHPEAK-SAQADLLNLKRKVDAGAN 178 +A DLV ++ F I VA + H E+ S +L +LK KVDAGA+ Sbjct: 122 PSDPRFTHAIDLVKYIRGSQEYSSHFCIGVA---DGHTESTCSEDEELEHLKAKVDAGAD 178 Query: 179 RAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQM 238 +TQ F+DV+ +L++ + + GI V IIPGI+P+ + + + ++P+ + Sbjct: 179 FIVTQLFYDVDRFLQWLKKVRAKGITVPIIPGIMPIQTYATFARLTKLCGTKVPSTLEAD 238 Query: 239 FDGLDDDAETRKLVGANIAMDMVKILSRE-GVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 + +D + K G A+ + L E G++ FHF TLN + + L R G+ Sbjct: 239 LLPIKNDDQLVKDYGVKYAVKTIHRLRNEGGIQGFHFCTLNLEKSVQRVLEELKWRTGV 297 >UniRef50_Q3A3T2 Methylenetetrahydrofolate reductase n=20 Tax=Bacteria RepID=Q3A3T2_PELCD Length = 301 Score = 304 bits (780), Expect = 2e-81, Method: Composition-based stats. Identities = 103/288 (35%), Positives = 158/288 (54%), Gaps = 16/288 (5%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + SFEFFPP+T + + L+ +I +L SL P F SVTYGA R+RTH ++ I + + Sbjct: 11 ETTFSFEFFPPKTDKAAERLYETIRQLESLHPHFTSVTYGAGGSTRERTHDLVMRIHESS 70 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM------YASDL 135 L+ PHLTC+ + E+ I + Y GI +I+AL GD PP + +A+DL Sbjct: 71 SLDPIPHLTCVSSPEQEIHQILKRYAEAGISNILALAGDPPPDMPHYDRSQDAFPHAADL 130 Query: 136 VTLLKEVAD---------FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFF 186 V +++ D F I VA +PE HP + ++ LK KVD GA+ TQ FF Sbjct: 131 VRFIRKFNDEGLHPDKRGFGIGVAGFPEGHPTTPNRLLEMDYLKAKVDEGADYICTQLFF 190 Query: 187 DVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADM-TNVRIPAWMAQMFDGLDDD 245 D + FR+RC AGI + II GI+P+++ + K+ A++ R PA + + D DD Sbjct: 191 DNRDFYDFRERCELAGISIPIIAGIMPIASVEGMKRMAELAAGARFPAPLLRAVDRCQDD 250 Query: 246 AETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 E+ + +G + A + + L V+ HFYTLN ++ + I LG++ Sbjct: 251 PESVRRIGIHWATEQCRDLLDNEVRGIHFYTLNNSDATRQIFQCLGLQ 298 >UniRef50_B2UQZ6 Methylenetetrahydrofolate reductase n=3 Tax=Verrucomicrobia RepID=B2UQZ6_AKKM8 Length = 311 Score = 304 bits (780), Expect = 2e-81, Method: Composition-based stats. Identities = 101/301 (33%), Positives = 154/301 (51%), Gaps = 17/301 (5%) Query: 12 LNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTH 71 L + L G ++SFEFFPP+ + L+ +I L +P FVSVTYGA R+ T Sbjct: 3 LRERLQSGAG-PSLSFEFFPPKNEQAASALYQTIRELEPYRPSFVSVTYGAGGSTRELTR 61 Query: 72 SIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP--- 128 ++ I+ + + PHLTC+ + +E+ I Y G+R ++ALRGD P G+ Sbjct: 62 EVVLRIQHESRIPTVPHLTCVGHSREEVWNILDQYARAGVRAVLALRGDPPRGAKDYNRD 121 Query: 129 ---EMYASDLVTLLKEVA---------DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAG 176 +A+DLVT ++E F I VA +PE HP + ++ LK KVDAG Sbjct: 122 ADVFRHAADLVTFIREYNESGRHPDPDGFAIGVAGFPEGHPATPNRLREMDFLKAKVDAG 181 Query: 177 ANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMT-NVRIPAWM 235 A+ TQ FFD S+L +R+RC+ AGI V I+ GI+PV++ + A+++ PA + Sbjct: 182 ADYICTQLFFDNHSFLDYRERCLLAGIKVPILAGIMPVTSLSGMNRMAELSGGTCFPARL 241 Query: 236 AQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPG 295 + + + + VG A L V HFYTLN++ + I LG++ Sbjct: 242 LKALKRAGSNPDAIQEVGIQYASSQCAELLDSDVDGIHFYTLNQSRATREIYRNLGLKDS 301 Query: 296 L 296 L Sbjct: 302 L 302 >UniRef50_B9XQY3 Methylenetetrahydrofolate reductase n=2 Tax=Verrucomicrobia RepID=B9XQY3_9BACT Length = 303 Score = 304 bits (778), Expect = 3e-81, Method: Composition-based stats. Identities = 104/301 (34%), Positives = 156/301 (51%), Gaps = 12/301 (3%) Query: 4 FHASQRDALNQSLAEVQG---QINVSFEFFPPRTSEMEQTL-WNSIDRLSSLKPKFVSVT 59 H Q + + + Q +SFEFFPP+T E ++ L +I L LKP F SVT Sbjct: 1 MHNRQLMQFIRDIYAAKADAHQPVISFEFFPPKTDEGDRALLEKTIPALLRLKPDFCSVT 60 Query: 60 YGANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRG 119 YGA G RD+T I+ I+ L HLTC++AT ++LR + + G+++I+ALRG Sbjct: 61 YGAGGGTRDKTLMIVDRIQREHQLPTMLHLTCVNATREQLRDVIEQARSLGVKNILALRG 120 Query: 120 DLPPGSGKP------EMYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQA-DLLNLKRK 172 D P G+G+ Y+ LV LL+E+ F I A +PE H K + D +LK+K Sbjct: 121 DPPGGNGEFKMTDGGFEYSHQLVALLRELGGFSIGTAGFPEGHIACKEGKHVDWEHLKKK 180 Query: 173 VDAGANRAITQFFFDVESYLRFRDRC-VSAGIDVEIIPGILPVSNFKQAKKFADMTNVRI 231 +D GA+ +TQ F++ Y FRD G V I PGILP+ + Q K+ + + ++ Sbjct: 181 IDCGADFVVTQLFYNNADYFEFRDHLTKKLGASVPIFPGILPILSAGQIKRISALCGAKL 240 Query: 232 PAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 P+ + + L D+ E G + A + L REG H YTLN+A + + L Sbjct: 241 PSRLVSCLEKLADNDEAAAAYGIDYATEQCAELLREGAPGLHMYTLNKAPSTIQVLKNLA 300 Query: 292 V 292 + Sbjct: 301 L 301 >UniRef50_B9WCV3 Methylenetetrahydrofolate reductase n=10 Tax=Saccharomycetales RepID=B9WCV3_CANDC Length = 640 Score = 303 bits (777), Expect = 4e-81, Method: Composition-based stats. Identities = 84/296 (28%), Positives = 147/296 (49%), Gaps = 16/296 (5%) Query: 10 DALNQSLAEVQ-GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERD 68 + + +A ++ + VSFEFFPP+T + L ++R+S+ P F++VT+GA + Sbjct: 2 STVAERIASLKPDEKFVSFEFFPPKTDSGFRNLLARLNRMSAFNPLFITVTWGAGGSTSE 61 Query: 69 RTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP 128 ++ + ++ G+ HLTC + + + G+R+I+ALRGD P Sbjct: 62 KSLDLAATCQNEIGITTVLHLTCTNTNKEVIDQALSKAKAAGVRNILALRGDPPRTEEYW 121 Query: 129 -----EMYASDLVTLLKEVAD--FDISVAAYPEVHPE-----AKSAQADLLNLKRKVDAG 176 A DLV ++E F I VAAYPE H + +++ Q D+ L KV AG Sbjct: 122 TPNCDFSGAVDLVKYIRENYGDYFCIGVAAYPEGHVDGSDISSQNPQKDIPFLVEKVKAG 181 Query: 177 ANRAITQFFFDVESYLRFRDRCVSAG--IDVEIIPGILPVSNFKQAKKFADMTNVRIPAW 234 A+ ITQ FFDVE ++ F + +IPG++P++ +K + A +++ IP Sbjct: 182 ADFIITQLFFDVEKFIAFEKLLKEHDELKGIPLIPGLMPITTYKVFNRAAKLSHASIPRG 241 Query: 235 MAQMFDGLDDDAETRKLVGANIAMDMVKIL-SREGVKDFHFYTLNRAEMSYAICHT 289 + + D + D K +G +I +++ + ++ +HFYTLN + +I Sbjct: 242 ILKQVDQVCHDDNAVKALGVDILTEIIDRIDKSTNIRGYHFYTLNLEKAVASILDK 297 >UniRef50_P42898 Methylenetetrahydrofolate reductase n=58 Tax=Metazoa RepID=MTHR_HUMAN Length = 656 Score = 302 bits (774), Expect = 1e-80, Method: Composition-based stats. Identities = 92/299 (30%), Positives = 144/299 (48%), Gaps = 13/299 (4%) Query: 5 HASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANS 64 H R+ + + L G S EFFPPRT+E L + DR+++ P ++ VT+ Sbjct: 42 HERLREKMRRRL--ESGDKWFSLEFFPPRTAEGAVNLISRFDRMAAGGPLYIDVTWHPAG 99 Query: 65 GE----RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD 120 + I + GLE H+TC +E+ G+++I+ALRGD Sbjct: 100 DPGSDKETSSMMIASTAVNYCGLETILHMTCCRQRLEEITGHLHKAKQLGLKNIMALRGD 159 Query: 121 LPPG----SGKPEMYASDLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVD 174 YA DLV ++ FDI VA YP+ HPEA S +ADL +LK KV Sbjct: 160 PIGDQWEEEEGGFNYAVDLVKHIRSEFGDYFDICVAGYPKGHPEAGSFEADLKHLKEKVS 219 Query: 175 AGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAW 234 AGA+ ITQ FF+ +++ RF C GI I+PGI P+ + ++ ++ + +P Sbjct: 220 AGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLEVPQE 279 Query: 235 MAQMFDGLDDDAETRKLVGANIAMDMVKILSREG-VKDFHFYTLNRAEMSYAICHTLGV 292 + + + + D+ + G +A+ + + L G V HFYTLNR + + LG+ Sbjct: 280 IKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLHFYTLNREMATTEVLKRLGM 338 >UniRef50_Q0AYF5 Methylenetetrahydrofolate reductase n=10 Tax=Bacteria RepID=Q0AYF5_SYNWW Length = 287 Score = 301 bits (772), Expect = 1e-80, Method: Composition-based stats. Identities = 96/273 (35%), Positives = 146/273 (53%), Gaps = 3/273 (1%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG-ERDRTHSIIKGIKD 79 + +S E FPPR + ++ +++ L L P F+SVTYGA T I IK+ Sbjct: 9 NKTVLSLEIFPPRRTASIGIIYKTLEELQGLNPDFISVTYGAGGSETNTATLEIASAIKN 68 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD--LPPGSGKPEMYASDLVT 137 G+E+ HL CI+ DE+ + + G+ +I+ALRGD + YASDLV+ Sbjct: 69 NYGIESVAHLPCINLNKDEVLNMLEGFKQAGVENILALRGDVNPARVPKQDFRYASDLVS 128 Query: 138 LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDR 197 +KE DF+I A YPE H E+ S D+ +LK KVDAG ++ ITQ FFD + FR+R Sbjct: 129 FIKENGDFNIIGACYPEGHSESPSLLDDIRHLKIKVDAGTDQLITQLFFDNSYFYSFRER 188 Query: 198 CVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIA 257 AGI+V I GI+PV N +Q ++ + V++P M + +++ E + G A Sbjct: 189 ASVAGINVAIEAGIMPVVNKRQIERMVALCGVKLPKKFVTMMERYENNPEAMRDAGIAYA 248 Query: 258 MDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 +D + L +GV H YT+N ++ I + Sbjct: 249 VDQIVDLIAQGVDGIHLYTMNNPYIAKKIYAAI 281 >UniRef50_O54235 5,10-methylenetetrahydrofolate reductase n=40 Tax=Bacteria RepID=METF_STRLI Length = 307 Score = 301 bits (772), Expect = 1e-80, Method: Composition-based stats. Identities = 109/301 (36%), Positives = 160/301 (53%), Gaps = 9/301 (2%) Query: 1 MSFFHASQRDALNQSLAE--VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSV 58 M+ AS R +++ + G+ SFEF P+T + E+ LW+++ R+ ++ P FVSV Sbjct: 1 MALGTASTRTDRARTVRDILATGKTTYSFEFSAPKTPKGEKNLWSALRRVEAVAPDFVSV 60 Query: 59 TYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALR 118 TYGA R T + I T L HLT +D + ELR I Y + GIR+++A+R Sbjct: 61 TYGAGGSTRAGTVRETQQIVADTTLTPVAHLTAVDHSVAELRNIIGQYADAGIRNMLAVR 120 Query: 119 GDLPPGSG-----KPEM--YASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKR 171 GD P PE YA++LV L+KE DF + VAA+PE+HP + D+ N Sbjct: 121 GDPPGDPNADWIAHPEGLTYAAELVRLIKESGDFCVGVAAFPEMHPRSADWDTDVTNFVD 180 Query: 172 KVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRI 231 K AGA+ AITQ FF +SYLR RDR +AG +IP ++PV++ K ++ ++N Sbjct: 181 KCRAGADYAITQMFFQPDSYLRLRDRVAAAGCATPVIPEVMPVTSVKMLERLPKLSNASF 240 Query: 232 PAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 PA + + DD + +G A + L EGV HF TLN + + I LG Sbjct: 241 PAELKERILTAKDDPAAVRSIGIEFATEFCARLLAEGVPGLHFITLNNSTATLEIYENLG 300 Query: 292 V 292 + Sbjct: 301 L 301 >UniRef50_Q3SVZ0 Methylenetetrahydrofolate reductase n=69 Tax=Proteobacteria RepID=Q3SVZ0_NITWN Length = 343 Score = 301 bits (770), Expect = 3e-80, Method: Composition-based stats. Identities = 146/285 (51%), Positives = 188/285 (65%), Gaps = 8/285 (2%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 + + +SFEFFPP+T EME+ LW +I RL+ L P FVSVTYGA R+RTHS I I Sbjct: 53 ARKRPTISFEFFPPKTEEMERNLWGTITRLAPLDPSFVSVTYGAGGSTRERTHSTIARIL 112 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG-----KPEMY-- 131 T L A HLTC+ A E+ I Y + G+RHIVALRGD P G G PE Y Sbjct: 113 SDTRLRPAAHLTCVGAPRGEIDEIVSRYRDIGVRHIVALRGDPPGGIGTAYSTHPEGYRT 172 Query: 132 ASDLVTLL-KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES 190 ++DLV + + D +ISV+AYPE HPE+ D+ LK KVDAGA RAITQ FFD Sbjct: 173 SADLVAGIKRRHGDIEISVSAYPEKHPESPDIDTDIDVLKAKVDAGATRAITQVFFDNNL 232 Query: 191 YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRK 250 YLR+ DR + GID+ I+PGI+P+ NFKQA+ F +PAW+A+ F+GLD+D ETRK Sbjct: 233 YLRYLDRVRARGIDIPIVPGIMPMHNFKQARAFVTKAGTTVPAWLAEKFEGLDEDPETRK 292 Query: 251 LVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPG 295 L+ A +A V+ L++ GV FHFYT+NRA++ +AICH LG+RP Sbjct: 293 LIAATVAAGQVQKLAKRGVDTFHFYTMNRADLVFAICHLLGIRPD 337 >UniRef50_C1SKU9 Methylenetetrahydrofolate reductase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SKU9_9BACT Length = 284 Score = 300 bits (768), Expect = 4e-80, Method: Composition-based stats. Identities = 100/279 (35%), Positives = 151/279 (54%), Gaps = 9/279 (3%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 ++ + +VSFEFFPP+ E EQ L+ +I +L P+FVSVTYGA ++T K +K Sbjct: 7 LKDKRSVSFEFFPPKKQESEQVLFETIKKLRRYNPEFVSVTYGAGGSTTEKTLEWTKRMK 66 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP-----EMYAS 133 + H TCI A + + + + + +I+ALRGD+P G+ + YA+ Sbjct: 67 EDHDYSVMMHFTCIGADAAVIDSATQSLKESRVDNILALRGDIPAGTTEFKPTKDFQYAA 126 Query: 134 DLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESY 191 DLV +++ F I VA YPE HPEA S D+ NLKRKVD GA+ ITQ FFD + Sbjct: 127 DLVRYIRKTTGDHFSIGVAGYPEKHPEAGSMAEDIDNLKRKVDEGADFIITQLFFDNFYF 186 Query: 192 LRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKL 251 + D+ AGI++ ++ GI+P+ N QA KF DM IP + + + D + + Sbjct: 187 YNYLDKVRKAGINIPVVAGIMPLVNLSQAVKFTDMCGASIPKPLLEKME--DKSLKDQFE 244 Query: 252 VGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 +G + A+ L G + HFYTLN+ ++ I + Sbjct: 245 IGLDYAVKQCGGLWESGAEGLHFYTLNKHGVTEEILKRI 283 >UniRef50_B6FS52 Methylenetetrahydrofolate reductase n=1 Tax=Clostridium nexile DSM 1787 RepID=B6FS52_9CLOT Length = 288 Score = 299 bits (766), Expect = 8e-80, Method: Composition-based stats. Identities = 97/284 (34%), Positives = 151/284 (53%), Gaps = 6/284 (2%) Query: 11 ALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRT 70 + L+E ++N+SFE FPP+T + + + +++LKP F+SVTYGA G T Sbjct: 2 KIKDRLSE--NRVNISFEVFPPKTDAGYGKVLEATEEIAALKPSFISVTYGAGGGTSKNT 59 Query: 71 HSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP-- 128 I I++ G+ + HLTC +T +E+R + GI++I+ALRGD+P P Sbjct: 60 VKIASHIQNDLGVASLAHLTCASSTKEEVRQVIEQLKEQGIQNILALRGDIPKDGAFPIP 119 Query: 129 --EMYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFF 186 YAS+L+ +K DF I A YPE H E++ D+ +LK KVD G + TQ FF Sbjct: 120 NHYKYASELIADIKSQGDFCIGAACYPEGHVESEHKSEDIAHLKEKVDVGVDFLTTQMFF 179 Query: 187 DVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDA 246 D F R GI V ++PGI+PV+N KQ + +++ +P + D DD Sbjct: 180 DNSILYNFLYRIREKGITVPVLPGIMPVTNGKQIARICELSGTILPERFRAIVDRFGDDP 239 Query: 247 ETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + + G A D + L G+++ H Y++N+ E++ AI L Sbjct: 240 KAMQQAGIAYATDQIIDLIANGIQNIHIYSMNKPEIAAAIMTNL 283 >UniRef50_C7LW31 Methylenetetrahydrofolate reductase n=2 Tax=Desulfovibrionales RepID=C7LW31_DESBD Length = 295 Score = 298 bits (764), Expect = 1e-79, Method: Composition-based stats. Identities = 96/287 (33%), Positives = 138/287 (48%), Gaps = 9/287 (3%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 + + +S EFFPP+ ++ + +L +L P F SVTYGA + T I+ +K Sbjct: 8 QRQEPFLSLEFFPPKDRAQWPGFFDVVRQLRALAPLFCSVTYGAGGSTQHNTLEIVTRMK 67 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS------GKPEMYA 132 GLE HLTC+ A L + G+ +++ALRGD P G + + Sbjct: 68 QEYGLEPLAHLTCVGADRARLGSFLSGLGEAGVDNVLALRGDPPRGETSFTPDSEEFQHG 127 Query: 133 SDLVTLLKE-VADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESY 191 SDLV+ +++ +D I VA YPE HPEA S DL L+ KV +GA+ ITQ FFD + Y Sbjct: 128 SDLVSFIRQEFSDLCIGVAGYPEKHPEAPSMADDLERLRHKVASGADFVITQLFFDNDRY 187 Query: 192 LRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDD--DAETR 249 F R +AGI V IIPGILPV N ++ +P + + + Sbjct: 188 FDFVVRARAAGIGVPIIPGILPVQNLGALQRMLTFCGASVPEGYMRDLEHVHKVYGESGV 247 Query: 250 KLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 + +G A ++ L G H YTLN+A+ I R GL Sbjct: 248 RGLGLGYAKSQIRNLLDRGAPGVHLYTLNKADTCLDIWKDFSSRDGL 294 >UniRef50_A1WXM6 Methylenetetrahydrofolate reductase n=221 Tax=Bacteria RepID=A1WXM6_HALHL Length = 304 Score = 298 bits (763), Expect = 2e-79, Method: Composition-based stats. Identities = 116/277 (41%), Positives = 163/277 (58%), Gaps = 6/277 (2%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 SFEFFPP+T E + L + +RL L P + SVT+GA +DRT + I+ + Sbjct: 9 RVFSFEFFPPKTDEGAENLKGTRERLERLNPAYFSVTFGAGGSTQDRTFETVIDIQRNST 68 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG----KPEMYASDLVTL 138 +AAPHL+CIDA+ D L+ + DY G+++IVALRGD P GSG YA++LV L Sbjct: 69 ADAAPHLSCIDASRDRLKQMILDYKEQGVKYIVALRGDRPSGSGSMGQGELSYANELVEL 128 Query: 139 LKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRD 196 ++EV F I V AYPE HPEA A D+ N RK AGA+ AITQFF++ + Y RF + Sbjct: 129 IREVTGDHFYIEVGAYPEFHPEAPDALTDIENFVRKAKAGADSAITQFFYNADCYYRFVE 188 Query: 197 RCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANI 256 C G+D+ I+PGI+P+ NF+Q +FA +P W+AQ + DD ++R G ++ Sbjct: 189 DCEKRGVDIPIVPGIMPLMNFEQQARFAAACKADMPRWLAQRMEAWKDDPQSRMEYGIDV 248 Query: 257 AMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 + + L G HFY LN+A + I H LG+ Sbjct: 249 VTRLCEDLLDNGAPGIHFYALNKAPVVERIWHNLGLS 285 >UniRef50_C5FI42 Methylenetetrahydrofolate reductase n=1 Tax=Microsporum canis CBS 113480 RepID=C5FI42_NANOT Length = 715 Score = 298 bits (763), Expect = 2e-79, Method: Composition-based stats. Identities = 87/295 (29%), Positives = 140/295 (47%), Gaps = 25/295 (8%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLS-SLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 S EFFPP+T L ++R+S +L+P FV+VT+GA R+ + + + + GL Sbjct: 18 FSLEFFPPKTQMGSSNLQARLERMSQALRPLFVTVTWGAGGSTAARSLELAEICQRQLGL 77 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG----------KPEMYAS 133 HLTC + + + GIR+I+ALRGD P K +A Sbjct: 78 TTCLHLTCTNMNRTLIDEALEETKALGIRNILALRGDPPRSEEYNIDGEDDSNKDFSHAV 137 Query: 134 DLVTLLKEVAD--FDISVAAYPEV-----HPEAKSAQADLLNLKRKVDAGANRAITQFFF 186 DLV +++ F I VA YPE HPE + DL L K AGA+ +TQ + Sbjct: 138 DLVRYIRKKYGDYFCIGVAGYPEGHADESHPEVQDPLKDLPYLIEKTQAGADFIMTQLTY 197 Query: 187 DVESYLRFRDRCVSAG----IDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGL 242 D+E+Y ++ D + + IIPG++P+ ++ + +++ +IP + + Sbjct: 198 DIEAYRKYEDLLRNHESGTFKTIPIIPGLMPIQSYHTLTRVTKLSHAKIPPEILAKVEAC 257 Query: 243 DDDAETRKLVGANIAMDMVKILSR---EGVKDFHFYTLNRAEMSYAICHTLGVRP 294 D E K VG +I ++V+ + + G + FHFYTLN + I + P Sbjct: 258 KADDEVVKRVGVDIVSELVEGIKKISTPGHRGFHFYTLNLEKSVSFILERCNLIP 312 >UniRef50_D1B7X9 Methylenetetrahydrofolate reductase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B7X9_THEAS Length = 298 Score = 297 bits (762), Expect = 2e-79, Method: Composition-based stats. Identities = 98/280 (35%), Positives = 140/280 (50%), Gaps = 6/280 (2%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 +G+ +SFE FPPR + ++ ++ + L P FVSVTYGA RD T I +K+ Sbjct: 9 RGRPVISFEIFPPRGGVPVEEVYRTLGAIKDLAPDFVSVTYGAGGSTRDATLEIASTVKN 68 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM----YASDL 135 R GLE H T + TP E+ + D G+ +++A+RGD P PE + SDL Sbjct: 69 RFGLEVMAHCTGLCHTPPEVHEMVEDLMYEGVHNLLAMRGDPPRDRHVPEGPSFPHGSDL 128 Query: 136 VTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLR 193 + L+ I+ AAYPE H EA+ + DL LK KVD GA ITQ FFD E + R Sbjct: 129 IGYLRRAFGDEVCIAAAAYPEGHVEARDMEEDLAFLKLKVDMGAELLITQLFFDNEIFYR 188 Query: 194 FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVG 253 F + GI V + GI PV N +Q ++ + V P +M DD + G Sbjct: 189 FLESIGRLGIRVPVCAGIFPVLNARQVERIVSLCGVSFPPKFTRMVARYADDPASLAEAG 248 Query: 254 ANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 A + + L GV H YT+NR + + I + +G+ Sbjct: 249 VAYATEQIVDLLAFGVDGIHIYTMNRPDTTRRIMNNIGLV 288 >UniRef50_Q21NJ7 Methylenetetrahydrofolate reductase n=2 Tax=Gammaproteobacteria RepID=Q21NJ7_SACD2 Length = 297 Score = 297 bits (761), Expect = 3e-79, Method: Composition-based stats. Identities = 107/280 (38%), Positives = 156/280 (55%), Gaps = 5/280 (1%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 Q + +SFEFFPP+T + L L+ + P F SVTYGA RD T I+K +++ Sbjct: 4 QQEFRLSFEFFPPKTDVGREKLITVRKELNDIHPDFFSVTYGAGGSTRDNTKGIVKKMRE 63 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG--SGKPEMYASDLVT 137 GL APHL+ T + + ++Y + G+ IVALRGD+P G + +YA++LV Sbjct: 64 E-GLNVAPHLSFGGDTEQTILPLLQEYKDMGVDRIVALRGDMPSGVGGAQQLVYANELVA 122 Query: 138 LLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFR 195 +++ D F + VAAYPE+HPEA S D+ LK K DAGAN AITQ+FF+ ++Y F Sbjct: 123 FIRKHFDDYFHLEVAAYPEIHPEATSYLDDVRYLKGKFDAGANSAITQYFFNPDAYFYFM 182 Query: 196 DRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGAN 255 D+C GID I PGI+P+ N++ +F+D IP WM + + D+ E G + Sbjct: 183 DQCQKEGIDQPIYPGIMPILNYRNLARFSDSCGADIPRWMRKRMESFGDNQEALISFGID 242 Query: 256 IAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPG 295 ++ L G HFYT+N+ E + I LG+ Sbjct: 243 WISELCDTLLDAGAPGLHFYTMNQTEPTATIIKNLGLEDA 282 >UniRef50_D1Y625 Methylenetetrahydrofolate reductase n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y625_9BACT Length = 292 Score = 297 bits (761), Expect = 3e-79, Method: Composition-based stats. Identities = 95/271 (35%), Positives = 148/271 (54%), Gaps = 3/271 (1%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 N SFE FPP+ + +++++++D L+SL+P +SVTYGA RD T I I++R Sbjct: 10 PNFSFEIFPPKRTGSLESIYSTVDALASLRPDLISVTYGAGGSNRDNTIEIASTIQNRYL 69 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG---SGKPEMYASDLVTLL 139 L A HLTC+ ++ ++ + + G+R I+ALRGD +A++LV + Sbjct: 70 LPAVAHLTCVGSSLEQTDALLAELKERGVRTILALRGDRRADADFEDGYFKHAAELVAHI 129 Query: 140 KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199 K+ DF + A YPE HPEA S +AD+ +LK KVDAG + ITQ F + + + RFRD Sbjct: 130 KKNYDFRVLGACYPEKHPEAPSLEADIAHLKEKVDAGVDALITQLFLNNDDFYRFRDLAQ 189 Query: 200 SAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMD 259 AG++V II GI+P++ K M IP + + D +AE + G A Sbjct: 190 KAGVNVPIIAGIMPITQASMLDKVVSMCGASIPPAVRRFVDAYGHNAEAVREAGIAYAAS 249 Query: 260 MVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + L GV+ H Y++N+A ++ I + Sbjct: 250 QIVDLLASGVEGIHIYSMNKAGVTRQIAQNI 280 >UniRef50_Q04NW1 Methylenetetrahydrofolate reductase n=5 Tax=Leptospira RepID=Q04NW1_LEPBJ Length = 290 Score = 297 bits (760), Expect = 3e-79, Method: Composition-based stats. Identities = 93/283 (32%), Positives = 144/283 (50%), Gaps = 7/283 (2%) Query: 16 LAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIK 75 + SFEFFPP+T + + L ++ L+ L P FV+VTYGA RD+T I+ Sbjct: 7 IYGSAKGPVYSFEFFPPKTQDGDLKLMGTVKELARLDPDFVTVTYGAGGSTRDKTAQILS 66 Query: 76 GIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------E 129 I H TC+ A D++ ++ ++GI +++ALRGD P G GK Sbjct: 67 EISKNYSFPTVSHFTCVGANQDQIFKTLKEIRSSGIVNLMALRGDPPKGEGKFKKTEGGF 126 Query: 130 MYASDLVTLLK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDV 188 A++L++ ++ E DF I YPE HP AKS + D+ NLKRKVDAG + ++Q FF Sbjct: 127 ENATELISFIRSEKLDFCIGGGCYPEKHPNAKSLEEDVRNLKRKVDAGTDFLVSQLFFVN 186 Query: 189 ESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAET 248 + F + A I +IPGI+P+++F Q ++F + P+ + + ++ E Sbjct: 187 SIFENFLNLVRKADIRAPVIPGIMPITSFSQIERFRSIAGCEFPSSLIEDLQEVEHRPEE 246 Query: 249 RKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 N ++ + L GV H YTLN++ SY I L Sbjct: 247 FYRRSLNFSIKQCRELLAMGVPGIHLYTLNQSHASYDIVRELK 289 >UniRef50_Q17693 Probable methylenetetrahydrofolate reductase n=5 Tax=Chromadorea RepID=MTHR_CAEEL Length = 663 Score = 296 bits (759), Expect = 5e-79, Method: Composition-based stats. Identities = 91/302 (30%), Positives = 142/302 (47%), Gaps = 13/302 (4%) Query: 2 SFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYG 61 + + + + + E Q S EFFPPR ++RLS FV +T+ Sbjct: 52 PKHYELLHERIERLIDEKQQ--FFSLEFFPPRFVNGVPNFLERVERLSEGGSVFVDMTWH 109 Query: 62 ANSGER-----DRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVA 116 S + SI + D G++ H+TC+ + G+R I+A Sbjct: 110 MGSDPANVDKVTSSSSIAASMLDYCGVDTMLHMTCVQYNKADTLKHLEQAKAMGLRSILA 169 Query: 117 LRGDLPPGSGKPEMY---ASDLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKR 171 LRGDLPPG+ + + A D++ ++E F I A YP HP+A S +ADL+ LK Sbjct: 170 LRGDLPPGTELEDTHQFRALDMIRWIREEYGNYFSIGCAGYPLGHPQAPSYKADLMYLKA 229 Query: 172 KVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRI 231 K DAGAN ITQ FF+ E++ +F C GI IIPGI+P+ ++ K+ A ++ + I Sbjct: 230 KCDAGANFVITQLFFEAETFEKFVRDCREIGITQPIIPGIMPIMGYESIKRIAKLSQLEI 289 Query: 232 PAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREG-VKDFHFYTLNRAEMSYAICHTL 290 P + + + D + + G ++M + L G H YT+NR I +L Sbjct: 290 PQHILDDLEPIKHDDDAVQKYGTERCIEMCRRLLDNGTAPSIHLYTMNREGSIREILKSL 349 Query: 291 GV 292 G+ Sbjct: 350 GL 351 >UniRef50_C5RR04 Methylenetetrahydrofolate reductase n=1 Tax=Clostridium cellulovorans 743B RepID=C5RR04_CLOCL Length = 285 Score = 296 bits (758), Expect = 7e-79, Method: Composition-based stats. Identities = 89/277 (32%), Positives = 144/277 (51%), Gaps = 2/277 (0%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 + + S E FPP+ ++ + N++D L+ L FVSVTYGA RD T + K IK Sbjct: 9 NRQSFSVELFPPKKTDSFDNIINTLDNLNGLDIDFVSVTYGAGGSSRDNTVKLSKKIKSE 68 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM-YASDLVTLL 139 LE HLTCI++ DE+ ++ + N + +I+ALRGD+P + YASDL+ + Sbjct: 69 YNLEVITHLTCINSKKDEIASLLDEMKENNLENILALRGDIPSEVIYDDYKYASDLIPEI 128 Query: 140 KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199 K + DF + A YPE HPEA S D+ LK+K G + I+Q F D + F++R Sbjct: 129 KSLGDFCVGAACYPEKHPEAPSNVYDIKKLKQKTALGCDFLISQLFLDNTMFFNFQERLE 188 Query: 200 SAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMD 259 A ++ +++ GI+PV N Q ++ ++ +P ++ + + + K G A+D Sbjct: 189 LADVNTKVLAGIMPVINKAQFERIIQLSGCNVPPKFKKILEKYEHNPSALKDAGIAYAID 248 Query: 260 MVKILSREGVKDFHFYTLNRAEMSYAICHTL-GVRPG 295 + L V H Y +N+ E + I + G+R Sbjct: 249 QIIDLMCHDVDGIHLYIMNKPENAKRILDNITGLRNA 285 >UniRef50_C8V780 Methylenetetrahydrofolate reductase n=17 Tax=Leotiomyceta RepID=C8V780_EMENI Length = 684 Score = 295 bits (756), Expect = 1e-78, Method: Composition-based stats. Identities = 87/300 (29%), Positives = 145/300 (48%), Gaps = 25/300 (8%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLS-SLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G S EFFPP+T L ++R++ +L+P FV+VT+GA R+ + + + Sbjct: 14 GANYFSLEFFPPKTQMGFANLQARLERMAQALRPLFVTVTWGAGGSTAARSLELAEICQR 73 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG----------KPE 129 + L HLTC + + + + GIR+I+ALRGD P K Sbjct: 74 QLQLTTCLHLTCTNMSRALVDQALEEAKVLGIRNILALRGDPPRSEEYNMHGEDDSNKDF 133 Query: 130 MYASDLVTLLKEVAD--FDISVAAYPEVHP-----EAKSAQADLLNLKRKVDAGANRAIT 182 +A DLV +++ F + VAAYPE HP + + + DL L K AGA+ +T Sbjct: 134 TFAVDLVRYIRKKYGDYFCVGVAAYPEGHPADSFQDIQDPKVDLPWLVEKTQAGADFIMT 193 Query: 183 QFFFDVESYLRFRDRCVSAG----IDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQM 238 Q +D+++Y F + + + IIPG++P+ ++K + +++V+IP + Sbjct: 194 QLTYDIDAYTEFENLLRNHESGTFKTIPIIPGLMPIHSYKILTRVTKLSHVKIPPPILAK 253 Query: 239 FDGLDDDAETRKLVGANIAMDMV---KILSREGVKDFHFYTLNRAEMSYAICHTLGVRPG 295 D + D + K +G +I ++V K L G++ FHFYTLN + I + P Sbjct: 254 LDEVKHDDDAVKRLGVDILAELVDGMKKLPTPGLRGFHFYTLNLEKTVSFILERCKLIPD 313 >UniRef50_Q5KN82 Methylenetetrahydrofolate reductase n=1 Tax=Filobasidiella neoformans RepID=Q5KN82_CRYNE Length = 633 Score = 295 bits (755), Expect = 2e-78, Method: Composition-based stats. Identities = 90/284 (31%), Positives = 136/284 (47%), Gaps = 16/284 (5%) Query: 27 FEFFPPRTSEMEQTLWNSIDRLSS---LKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 +EFFPP T L + I RL+S P VSVT+GA +++ + + + G+ Sbjct: 18 YEFFPPLTDPGFVNLLDRIRRLTSSPFQAPLAVSVTWGAGGSTAEKSLELAQQVV-DMGV 76 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK---------PEMYASD 134 E HLTC + D++ R + GI +I+ALRGD P +A D Sbjct: 77 EVILHLTCTNMPKDKVDFALRRCKDLGISNILALRGDPPREEEYAINPTSTPDFFKHADD 136 Query: 135 LVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYL 192 LV +++ F I VA YP HP+++S + D K K DAGA+ +TQ F+DV+ +L Sbjct: 137 LVRYIRQTHGDYFCIGVAGYPNPHPDSESEEEDFKWFKAKCDAGADFIVTQLFYDVDVFL 196 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV 252 + C + GI+ IIPGI+P+ N+ ++ ++T +P + + D T K Sbjct: 197 EWVKTCRARGINQPIIPGIMPIQNYASFRRLVNLTKCPVPDSITSDLQPISSDDATVKRY 256 Query: 253 GANIAMDMVKILSREG-VKDFHFYTLNRAEMSYAICHTLGVRPG 295 GA +A MV + G V H TLN + I LG Sbjct: 257 GAELATKMVSQIIESGLVPGVHLCTLNLEKSVRMILDNLGWSAA 300 >UniRef50_P53128 Methylenetetrahydrofolate reductase 2 n=42 Tax=Ascomycota RepID=MTHR2_YEAST Length = 600 Score = 295 bits (755), Expect = 2e-78, Method: Composition-based stats. Identities = 89/291 (30%), Positives = 149/291 (51%), Gaps = 13/291 (4%) Query: 17 AEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLK-PKFVSVTYGANS-GERDRTHSII 74 + G+ SFE+F P+T++ Q L++ +DR+ P+F+ +T+ A + ++ Sbjct: 11 RQTSGKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGGGRLSHLSTDLV 70 Query: 75 KGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------ 128 + GLE HLTC + + + +++G ++I+ALRGD P + Sbjct: 71 ATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPRDAENWTPVEGG 130 Query: 129 EMYASDLVTLLKEVAD--FDISVAAYPEVHPEAK--SAQADLLNLKRKVDAGANRAITQF 184 YA DL+ +K F I VA YPE HPE + DL LK+K+DAG + ITQ Sbjct: 131 FQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPNKDVKLDLEYLKQKIDAGGDFIITQM 190 Query: 185 FFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDD 244 F+DV++++ + + +AG+DV IIPGI+P++ + + A + IP + D + D Sbjct: 191 FYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQWGQISIPQHFSSRLDPIKD 250 Query: 245 DAETRKLVGANIAMDMVKILSREG-VKDFHFYTLNRAEMSYAICHTLGVRP 294 D E + +G N+ ++M + L G V H YT+N + I L + P Sbjct: 251 DDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLMILERLNILP 301 >UniRef50_Q5FNV4 Methylenetetrahydrofolate reductase n=1 Tax=Gluconobacter oxydans RepID=Q5FNV4_GLUOX Length = 309 Score = 294 bits (754), Expect = 2e-78, Method: Composition-based stats. Identities = 136/278 (48%), Positives = 181/278 (65%), Gaps = 5/278 (1%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 +SFE PPRT MEQ LW + RL+ L P+FVSVTYGA + +T + + +K T Sbjct: 27 PVLSFEVVPPRTDAMEQRLWQCMRRLAPLSPRFVSVTYGACGTMQAQTQATVLRLKQETT 86 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG---KP--EMYASDLVT 137 L A HLTCI AT +E+ IAR YW G+RHI+ALRGD P G+ P YA DLV Sbjct: 87 LVPAAHLTCIGATREEIDDIARTYWQAGVRHILALRGDAPAGTDYTPHPGGYAYAGDLVA 146 Query: 138 LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDR 197 L+ +ADF+ISVAAYPE HP A + QAD+ NLKRK DAGA+RAITQ+FF+ + LRF DR Sbjct: 147 GLRRIADFEISVAAYPETHPTAPNPQADIDNLKRKFDAGASRAITQYFFEASTCLRFLDR 206 Query: 198 CVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIA 257 C++AGI I+PGI+PVSN+ +F+ V +P W+ +F+G + E ++ +A Sbjct: 207 CLAAGITAPIVPGIMPVSNYDHIARFSAFCGVTVPVWLTHLFEGTAKNPELCRIAACIVA 266 Query: 258 MDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPG 295 + V+ L G+ +FHF TLNR +++ AI H LGVRP Sbjct: 267 AEQVRTLQSHGINEFHFSTLNRPDLTCAIAHLLGVRPA 304 >UniRef50_A0LTK4 Methylenetetrahydrofolate reductase n=19 Tax=Actinomycetales RepID=A0LTK4_ACIC1 Length = 331 Score = 294 bits (753), Expect = 2e-78, Method: Composition-based stats. Identities = 106/282 (37%), Positives = 151/282 (53%), Gaps = 7/282 (2%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 +G + SFEFFPP+T++ E+ L+ +I L L+P FVSVTYGA T I + I Sbjct: 21 ARGGSSFSFEFFPPKTADGERALFQTIRALEVLRPTFVSVTYGAGGSTAAATVRITERIA 80 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG-------KPEMY 131 T L HLT ++ + E+R + Y G+R+I+ALRGD P Y Sbjct: 81 TETTLTPVGHLTIVNQSVAEIRRVIGQYAAAGVRNILALRGDPPGNPNGEWIPHPHGFRY 140 Query: 132 ASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESY 191 A +LV LLK V DF + VAA+P HP + + + D K AGA+ AITQ FF VE Y Sbjct: 141 AVELVRLLKMVGDFCVGVAAFPRKHPRSPTLEDDTRYFVEKCRAGADFAITQMFFRVEDY 200 Query: 192 LRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKL 251 LR R+R AG V IIPG++P+++ Q ++FA ++ P +A + D + Sbjct: 201 LRLRERIERAGCTVPIIPGVMPITSIGQIERFALLSGDEFPPELADRILAVADQPAAVRA 260 Query: 252 VGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 +G +A +M + L EG HFYTLNR+ + I L + Sbjct: 261 IGIEVATEMCRRLLDEGAPGLHFYTLNRSTATREIYQNLRLS 302 >UniRef50_A2QUJ5 Methylenetetrahydrofolate reductase n=16 Tax=Leotiomyceta RepID=A2QUJ5_ASPNC Length = 699 Score = 293 bits (751), Expect = 4e-78, Method: Composition-based stats. Identities = 85/295 (28%), Positives = 143/295 (48%), Gaps = 25/295 (8%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLS-SLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 S EFFPP+T L ++R++ +L+P FV+VT+GA R+ + + + + L Sbjct: 18 FSLEFFPPKTKMGFANLQARLERMAQALRPLFVTVTWGAGGSTAARSLELAEICQRQLQL 77 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG----------KPEMYAS 133 HLTC + + + + GIR+I+ALRGD P K +A Sbjct: 78 TTCLHLTCTNMSRALVDEALEEAKVLGIRNILALRGDPPRSEEYNMHGEDDSNKDFTFAV 137 Query: 134 DLVTLLKEVAD--FDISVAAYPEVHP-----EAKSAQADLLNLKRKVDAGANRAITQFFF 186 DLV +++ F I VAAYPE HP + + DL L K AGA+ +TQ + Sbjct: 138 DLVRYIRKQYGDYFCIGVAAYPEGHPADNFQDGQDPARDLPFLIEKTQAGADFIMTQLTY 197 Query: 187 DVESYLRFRDRCVSAG----IDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGL 242 D+E+Y +F + + I+PG++P+ ++K + +++V+IP + + + Sbjct: 198 DLEAYTKFETMLRNHESGVFKTIPIVPGLMPIHSYKILTRVTKLSHVKIPPHVLSKLEEV 257 Query: 243 DDDAETRKLVGANIAMDM---VKILSREGVKDFHFYTLNRAEMSYAICHTLGVRP 294 D + K +G +I D+ ++ L G++ FHFYTLN + I + P Sbjct: 258 KHDDDAVKRIGVDIISDLVHGIRDLVSPGLRGFHFYTLNLEKTVSFILERCELIP 312 >UniRef50_B1L1W9 Methylenetetrahydrofolate reductase n=30 Tax=Bacteria RepID=B1L1W9_CLOBM Length = 295 Score = 293 bits (751), Expect = 5e-78, Method: Composition-based stats. Identities = 94/271 (34%), Positives = 147/271 (54%), Gaps = 3/271 (1%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERD-RTHSIIKGIKD 79 ++ SFE FP + + T++ +++ L L P F+SVTYGA +D +T + +K+ Sbjct: 10 KKLVFSFEIFPSKVTSSITTIYETLEELKDLTPDFISVTYGAGGSLKDNKTCELSSLVKN 69 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG--KPEMYASDLVT 137 + G+EA HLTCI++T D++ I ++ N I +I+ALRGD+P YA +L+ Sbjct: 70 KYGIEALAHLTCINSTKDDIDLIIKELKENNIENILALRGDIPKDKDIIGEYNYAFELIE 129 Query: 138 LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDR 197 +K +F IS A YPE H E KS D+ LKRKVDAGA I+Q FFD + F ++ Sbjct: 130 KIKASNNFGISGACYPEGHIECKSLDQDIRELKRKVDAGAEHLISQLFFDNNIFYEFLNK 189 Query: 198 CVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIA 257 I+V I GI+PV N KQ ++ ++ +P ++ D + D + + G A Sbjct: 190 TQEKSINVPIQAGIMPVVNKKQIERIVKISGATLPKKFMKILDKYEYDKKAMEDAGIAYA 249 Query: 258 MDMVKILSREGVKDFHFYTLNRAEMSYAICH 288 ++ + L GVK H YT+N ++ I Sbjct: 250 VEQIVDLVSSGVKGIHLYTMNNPYIARKITE 280 >UniRef50_Q0AZY6 Methylenetetrahydrofolate reductase n=5 Tax=Clostridiales RepID=Q0AZY6_SYNWW Length = 295 Score = 292 bits (747), Expect = 1e-77, Method: Composition-based stats. Identities = 93/286 (32%), Positives = 149/286 (52%), Gaps = 9/286 (3%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 Q +S E FPPR + +++++++ L L P ++SVTYGA R+RT I +K Sbjct: 8 RQKAPLLSLEIFPPRMAYPLESVFDTVQELKRLNPAYISVTYGAGGSNRERTVEIAARVK 67 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM------YA 132 G+EA HLTCI ++++ I GI +I+ALRGD+P + + YA Sbjct: 68 KEYGIEAQAHLTCIGHRQEDIKNILARLNREGICNIMALRGDIPEDEPEFDFRRQEYHYA 127 Query: 133 SDLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES 190 +L+ ++ F I+ AA+PE HPE + D+ +LK KVD G + ITQ FFD Sbjct: 128 FELIRDIRAAYGDSFGIAAAAHPEGHPECPRLKDDIFHLKNKVDNGVDFLITQLFFDNRI 187 Query: 191 YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRK 250 + F +RC + GI+ +IPGI+PV N Q K+ + +PA + ++ D + + + Sbjct: 188 FFDFWERCQAMGINCPVIPGIMPVLNAGQIKRMIYLCGASMPAGLLKLVDKYEKEPVDME 247 Query: 251 LVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV-RPG 295 G + A +K L V H Y++N+ I + +G+ PG Sbjct: 248 KAGIDYASQQIKELLENAVAGVHLYSMNKPRQISEIVYNIGLASPG 293 >UniRef50_Q89B13 5,10-methylenetetrahydrofolate reductase n=74 Tax=Proteobacteria RepID=METF_BUCBP Length = 295 Score = 292 bits (747), Expect = 1e-77, Method: Composition-based stats. Identities = 159/291 (54%), Positives = 219/291 (75%), Gaps = 1/291 (0%) Query: 1 MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY 60 M + + + LNQ L + ++N+SFEFFPP E+ LW ID+L L PKF SVT+ Sbjct: 1 MKLVYKNYHETLNQHLMNICEKVNISFEFFPPNNILSEKNLWQVIDKLKLLTPKFFSVTH 60 Query: 61 GANSGERDR-THSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRG 119 G NS R T +I+K IK TG+E PHLTCI++T +EL+ IA+ YW++GIRHI+ALRG Sbjct: 61 GTNSKIRATCTSNIVKKIKKYTGIETVPHLTCINSTEEELKVIAKTYWDSGIRHILALRG 120 Query: 120 DLPPGSGKPEMYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANR 179 D+ + KP++YA DL+ LLK +A+F+ISVAAYPEVHPEA +A+ D++NLKRKV+AGA R Sbjct: 121 DIFNTNCKPKIYAVDLIKLLKSIANFEISVAAYPEVHPEAVNAKYDIINLKRKVEAGATR 180 Query: 180 AITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMF 239 AITQFFF+++ +LRFRD CV I ++I+PGI P+SNFKQ KF+ ++NV IP W+ MF Sbjct: 181 AITQFFFNIDCFLRFRDLCVKNNITIDIVPGIFPISNFKQLLKFSSVSNVSIPKWLCCMF 240 Query: 240 DGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 GLD+D T +++G++IA+DMVK+L EG++ FHFYTLN++E+S+AIC L Sbjct: 241 HGLDNDLNTSRIIGSSIAIDMVKVLYSEGIRSFHFYTLNKSEISFAICKIL 291 >UniRef50_B1ZNX1 Methylenetetrahydrofolate reductase n=2 Tax=Opitutaceae RepID=B1ZNX1_OPITP Length = 292 Score = 291 bits (746), Expect = 2e-77, Method: Composition-based stats. Identities = 102/265 (38%), Positives = 147/265 (55%), Gaps = 7/265 (2%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + S EF+PP+ + + L + L + P FVSVTYGA ++RT + ++ Sbjct: 15 RPVRSLEFYPPKDAAGVEALRATAHALRRMLPDFVSVTYGAGGSTQERTAQVSSILRKDC 74 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYASDL 135 G PHLTC+ + EL +A + ++G R+I+ALRGD P GS + YA+DL Sbjct: 75 GFTVMPHLTCVGHSQLELAALADGFHDHGFRNIMALRGDPPKGSAQFTPQPDGLRYAADL 134 Query: 136 VTLLK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 VTLLK DF + VA YPE HPEA S DL NLKRKVDAGA+ TQ FFD Y RF Sbjct: 135 VTLLKSRHTDFCLGVAGYPEKHPEAASLDVDLTNLKRKVDAGADFITTQLFFDNTVYYRF 194 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGA 254 ++C + GI V I+PGI+PV + Q ++F M +P + + ++ + + +G Sbjct: 195 VEKCRAVGITVPIVPGIMPVLSLHQIQRFTAMCGATLPKQLITRLEVAAENTDVVETIGI 254 Query: 255 NIAMDMVKILSREGVKDFHFYTLNR 279 + A+ ++ L G +H Y LNR Sbjct: 255 DWALTQIRGLLANGAPGYHLYVLNR 279 >UniRef50_D2QYY6 5,10-methylenetetrahydrofolate reductase n=3 Tax=Planctomycetaceae RepID=D2QYY6_9PLAN Length = 292 Score = 291 bits (746), Expect = 2e-77, Method: Composition-based stats. Identities = 114/281 (40%), Positives = 159/281 (56%), Gaps = 8/281 (2%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G+ +SFE FPP+T+ E ++ SI L + +P ++ TYGA RD+T I +K Sbjct: 6 SGKRTLSFELFPPKTTAGETAMYQSIGELMAFQPDVITCTYGAGGSTRDKTLEITASVKQ 65 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM------YAS 133 + G++ A HLTC+ +T D+LR RD + G+ +IVALRGD P G +M YAS Sbjct: 66 QFGVKVASHLTCVGSTQDQLRDYLRDAISRGVENIVALRGDPPKGETSFQMCEGGLRYAS 125 Query: 134 DLVTLLK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYL 192 DLV L+K + + I+VA YPE H EA S DL NLKRKVDAG + ITQ F+D + Sbjct: 126 DLVALIKADFPELGIAVAGYPETHQEAISYADDLANLKRKVDAGGDAIITQLFYDNADFF 185 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV 252 RFRD C + GI V IIPGILPV+N Q ++ + ++P+ G DD + V Sbjct: 186 RFRDDCDALGITVPIIPGILPVTNLAQIQRITSLCKAKLPSVFVAKL-GEQDDTAWQFQV 244 Query: 253 GANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 G A V+ L GV HFY LN+++ + + +G Sbjct: 245 GVEQATVQVQELLHAGVPGIHFYVLNKSQATSEVLRGIGWS 285 >UniRef50_A8XGR9 Methylenetetrahydrofolate reductase n=1 Tax=Caenorhabditis briggsae RepID=A8XGR9_CAEBR Length = 724 Score = 290 bits (743), Expect = 3e-77, Method: Composition-based stats. Identities = 90/315 (28%), Positives = 138/315 (43%), Gaps = 29/315 (9%) Query: 5 HASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANS 64 + + + + + E S EFFPPR ++RLS FV +T+ S Sbjct: 90 YELLHERIERLIEEKT--PFFSLEFFPPRFVNGVPNFLERVERLSEGGSVFVDMTWHMGS 147 Query: 65 GER-----DRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRG 119 + SI + D G++ H+TC+ + G+R I+ALRG Sbjct: 148 DPANIDKVTSSSSIAASMLDYCGVDTMLHMTCVQYNKADTLKHLEQAKAMGLRSILALRG 207 Query: 120 DLPPG-------------------SGKPEMYASDLVTLLKEVAD--FDISVAAYPEVHPE 158 DLPPG + A D++ ++E F I A YP HP+ Sbjct: 208 DLPPGVCCGIVSNSFFIFMFQTELEDTNQFRALDMIRWIREEYGDYFSIGCAGYPLGHPQ 267 Query: 159 AKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFK 218 A S +ADL LK K DAGAN ITQ FF+ E++ +F C GI IIPGI+P+ ++ Sbjct: 268 APSYKADLQYLKAKCDAGANFVITQLFFEPETFEKFVADCREIGITKPIIPGIMPIMGYE 327 Query: 219 QAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREG-VKDFHFYTL 277 K+ A ++ + IP + + + + D + + G ++M + L G H YT+ Sbjct: 328 SIKRIAKLSQLEIPEHILEDLEPIKHDDDAVQKYGTERCIEMCRRLLDNGSAPSIHLYTM 387 Query: 278 NRAEMSYAICHTLGV 292 NR I LG+ Sbjct: 388 NREGSIREILKALGL 402 >UniRef50_C4Y9Q4 Methylenetetrahydrofolate reductase n=1 Tax=Clavispora lusitaniae ATCC 42720 RepID=C4Y9Q4_CLAL4 Length = 601 Score = 290 bits (743), Expect = 3e-77, Method: Composition-based stats. Identities = 85/283 (30%), Positives = 135/283 (47%), Gaps = 15/283 (5%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 + SFEFFPP+T + L + R+ L P FVSVT+GA +++ + + Sbjct: 13 DEKFCSFEFFPPKTDAGFRNLLARLHRMRDLNPLFVSVTWGAGGSTSEKSLELAVTCQQL 72 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP-----EMYASDL 135 G+ HLTC + + GIR+I+ALRGD P A DL Sbjct: 73 LGISTVLHLTCTNTNKAIIDDALSRAKAAGIRNILALRGDPPRTREYWTPECSFRTAVDL 132 Query: 136 VTLLKEVAD--FDISVAAYPEVHPEA-----KSAQADLLNLKRKVDAGANRAITQFFFDV 188 V ++ F I VA YPE H + + + DL L+ KV AGA+ +TQ FFD Sbjct: 133 VRYIRAQYGDYFCIGVAGYPEGHVDGSDGAEQDPKRDLPYLEEKVAAGASFVVTQMFFDA 192 Query: 189 ESYLRFRDRCVSAGI--DVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDA 246 + Y+ F ++ + DV +IPG++P++ +K + +++ +PA +A+ D Sbjct: 193 DKYVAFEKMVRASPVLKDVVLIPGLMPITTYKVFTRATKLSHASVPAAVAEQLSSAAVDD 252 Query: 247 ETRKLVGANIAMDMVKIL-SREGVKDFHFYTLNRAEMSYAICH 288 + K +G ++ +V + +R + FHFYTLN AI Sbjct: 253 DQVKKIGVDVLSQLVADVSARSAARGFHFYTLNLERAVAAIVE 295 >UniRef50_A6TTI5 Methylenetetrahydrofolate reductase n=3 Tax=Clostridiales RepID=A6TTI5_ALKMQ Length = 294 Score = 290 bits (742), Expect = 5e-77, Method: Composition-based stats. Identities = 85/273 (31%), Positives = 139/273 (50%), Gaps = 4/273 (1%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 + +SFE FPP+ +++ ++D L+ L P F+SVTYGA ++T I IK++ Sbjct: 10 KRPVISFEIFPPKKELPISSIYGALDGLADLNPDFISVTYGAGGTGSNKTIEIASIIKNK 69 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG----SGKPEMYASDLV 136 +EA HLTCI + + ++ + N + +++ALRGD+P Y DL+ Sbjct: 70 YEIEALAHLTCITSNKEVIQQNIKALQENNLENVLALRGDVPSDFIRREENQYQYGVDLI 129 Query: 137 TLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRD 196 LK DFDI A YPE H E + DL LK K AGAN ++Q FFD E + F + Sbjct: 130 KELKGYGDFDIGAAVYPEGHIECDDVEKDLQYLKEKEAAGANFLVSQLFFDNEIFYGFLE 189 Query: 197 RCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANI 256 + + I+ +++ G++P+ + KQ +K M +PA + ++ + E + G Sbjct: 190 KLKAYKIESKVLAGVMPILSKKQVEKMIFMCGASLPAKVIRLVSKYEHQPELLRQAGIEY 249 Query: 257 AMDMVKILSREGVKDFHFYTLNRAEMSYAICHT 289 A + V L V H YT+N+ +++ I Sbjct: 250 AAEQVADLIANEVDGIHIYTMNQPDIAKGILKR 282 >UniRef50_C5DIA7 Methylenetetrahydrofolate reductase n=2 Tax=Saccharomycetaceae RepID=C5DIA7_LACTC Length = 660 Score = 290 bits (742), Expect = 5e-77, Method: Composition-based stats. Identities = 88/291 (30%), Positives = 140/291 (48%), Gaps = 20/291 (6%) Query: 17 AEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKG 76 E +S EFFPP+T +Q L + R+++L P F+++T+GA +T + Sbjct: 27 YESTDGPFISLEFFPPKTKLGKQNLTARMTRMTALNPLFITITWGAGGTTAKKTLELATV 86 Query: 77 IKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP-------PGSGKPE 129 + + HLTC + + + + IR+I+ALRGD P P Sbjct: 87 AQRELNVPVCMHLTCTNTNKEIIDEALKLAHEADIRNILALRGDPPVGEEWETPSESSEF 146 Query: 130 MYASDLVTLLKEVA--DFDISVAAYPEVHPE------AKSAQADLLNLKRKVDAGANRAI 181 +A DLV +KE DF + VAAYPE H E A+ + DL LK KVDAGA+ I Sbjct: 147 QHAVDLVRYIKEKYNDDFCVGVAAYPEGHCEGEADGVAQDPRRDLGFLKEKVDAGADFVI 206 Query: 182 TQFFFDVESYLRFRDRCV-SAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMF- 239 TQ F+DVE +L F D+ + PG++P++++ + A +++ IP + Sbjct: 207 TQLFYDVEKFLSFEQMFRNEVSADIPLFPGLMPINSYLLFNRAAKLSHASIPQAIRDRLP 266 Query: 240 DGLDDDAETRKLVGANIAMDMVKILSRE---GVKDFHFYTLNRAEMSYAIC 287 D + +G +I ++MV+ + + +K HFYTLN + I Sbjct: 267 QEYHSDDNKVRAIGVDILVEMVEEIYKRTEGRIKGIHFYTLNLEKAIAQIV 317 >UniRef50_C6NUC2 Methylenetetrahydrofolate reductase n=1 Tax=Acidithiobacillus caldus ATCC 51756 RepID=C6NUC2_9GAMM Length = 276 Score = 290 bits (742), Expect = 5e-77, Method: Composition-based stats. Identities = 108/270 (40%), Positives = 153/270 (56%), Gaps = 2/270 (0%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 S EFFPP+ E L +I L +L+P + SVTYGA ++RT + + + T LE Sbjct: 7 FSVEFFPPKNPAGEAKLRETIGALQALRPDYASVTYGAAGSTQERTLATVAMLARDTELE 66 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP--EMYASDLVTLLKEV 142 A PHLTCI +T +R I Y GIR IVALRGDLPP P A DL+ ++ Sbjct: 67 AVPHLTCIGSTEAGIRAILEHYRELGIRRIVALRGDLPPDREDPGFFHQALDLIAYIRAF 126 Query: 143 ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAG 202 F I AAYPE HP A A+ADL L+RKV+AGA+ ITQ+F++ ++YL+ RD G Sbjct: 127 GGFQIYAAAYPEFHPRAVHARADLEYLQRKVEAGASGLITQYFYNPDAYLQLRDDLARRG 186 Query: 203 IDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVK 262 +DV I G++P++N+ Q F+ IP ++ + + DD + + +A + Sbjct: 187 VDVPITVGVMPMTNYAQIANFSAQCGAEIPQFLRRRMESFADDPGAQAELAIEVASRQCR 246 Query: 263 ILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 +L +G HFYTLN+AE + AI LG+ Sbjct: 247 LLLDQGAPGLHFYTLNQAEATLAIARNLGL 276 >UniRef50_C4R2L4 Methylenetetrahydrofolate reductase n=1 Tax=Pichia pastoris GS115 RepID=C4R2L4_PICPG Length = 596 Score = 288 bits (737), Expect = 2e-76, Method: Composition-based stats. Identities = 88/301 (29%), Positives = 149/301 (49%), Gaps = 17/301 (5%) Query: 10 DALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDR 69 + + E++G+ SFEFFPP+T + L + R+S L P FV+VT+GA + Sbjct: 2 TKIIDKIKELKGEPFYSFEFFPPKTDNGLRNLLARLGRMSMLNPLFVTVTWGAGGTTSSK 61 Query: 70 THSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS---- 125 T + + L HLTC + + + + ++NGI++I+ALRGD P + Sbjct: 62 TLDLAITCQKDLDLTTCIHLTCTNTSKKLIDNALKAAYDNGIKNILALRGDPPREAQEVA 121 Query: 126 -GKPEMYASDLVTLLKEVAD--FDISVAAYPEVHPEAKS-----AQADLLNLKRKVDAGA 177 + YA DLV ++ F I VAAYPE H E D+ L K++AGA Sbjct: 122 VDQDFKYAIDLVRYIRGQYGDYFCIGVAAYPEGHVEGNDDSEQSIDHDMPYLLEKINAGA 181 Query: 178 NRAITQFFFDVESYLRFRDRCVSA-GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMA 236 + +TQ F+D + + F + G DV +IPG++P++ ++ ++ ++++ IP + Sbjct: 182 DFVVTQLFYDADKFCTFYNTLKQRLGRDVVVIPGLMPINTYQLFQRATNLSHASIPPAVG 241 Query: 237 QMFDG-LDDDAETRKLVGANIAMDMVKILSRE---GVKDFHFYTLNRAEMSYAICHTLGV 292 Q+F + D + K +G + +D+V + E V +HFYTLN + I + Sbjct: 242 QLFPPDVRHDDDKVKDIGVKLMIDIVDQIYNETHGEVNGYHFYTLNLEKSVAQIVDKSSL 301 Query: 293 R 293 Sbjct: 302 L 302 >UniRef50_Q169G2 Methylenetetrahydrofolate reductase n=39 Tax=Rhodobacterales RepID=Q169G2_ROSDO Length = 289 Score = 287 bits (736), Expect = 2e-76, Method: Composition-based stats. Identities = 127/280 (45%), Positives = 159/280 (56%), Gaps = 7/280 (2%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 VSFE FPPR+ + LW + L+ L P+F SVTYGA RD TH + +G Sbjct: 4 PEVSFEVFPPRSIDASFKLWETAQALAPLAPRFFSVTYGAGGTTRDLTHDAAYTLHKSSG 63 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYASDLV 136 L A HLTC+ A+ E IA+ + GI IVALRGD P GS A +L+ Sbjct: 64 LPVAAHLTCVGASKSETLAIAQRFAQAGITDIVALRGDAPEGSNGFTPHPDGFANAVELI 123 Query: 137 TLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRD 196 L F + V AYPE HPEA S QA++ LK KVDAGA AITQFFF+ +++LRFRD Sbjct: 124 DALARSGQFTLRVGAYPEKHPEAASQQANIDWLKAKVDAGACEAITQFFFEADTFLRFRD 183 Query: 197 RCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANI 256 CV AGI V I PGILP++N+ A+KFA IPAW+ Q FD D L+ + Sbjct: 184 DCVRAGISVPITPGILPITNWTNARKFAQRCGTSIPAWLDQAFDAAIRDD-RHDLLSRAL 242 Query: 257 AMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 ++ L EGV HFYTLNR E++ ICH LGV + Sbjct: 243 CTELCSDLVGEGVDKLHFYTLNRPELTREICHALGVTQAV 282 >UniRef50_A8MFK9 Methylenetetrahydrofolate reductase n=7 Tax=Clostridiales RepID=A8MFK9_ALKOO Length = 298 Score = 287 bits (736), Expect = 3e-76, Method: Composition-based stats. Identities = 88/276 (31%), Positives = 153/276 (55%), Gaps = 5/276 (1%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERD-RTHSIIKGIK 78 + + SFE FPP+ + +++++++ L LKP ++SVTYGA D RT I IK Sbjct: 9 RKNLVFSFEVFPPKVTSPIGSIYDTLEGLQDLKPDYISVTYGAGGNGNDNRTGEIAAIIK 68 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG--SGKPEMYASDLV 136 ++ G+EA HLTCI +T ++ + + ++ + G+ +++ALRGD+P G + DL+ Sbjct: 69 NKYGIEALAHLTCIGSTLEQTKGVLQELRDKGVHNVLALRGDIPEGFEGKGELKNSQDLI 128 Query: 137 TLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 L++E F I+ A YPE H E K+ D+ LK K +AGA+ AITQ FFD + F Sbjct: 129 RLIREDQGNRFGIAAACYPEGHVEGKNVDQDIEILKLKEEAGADHAITQLFFDNNYFYEF 188 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGA 254 ++ GI + I GI+PV+N KQ ++ ++ +P ++ + + + E + G Sbjct: 189 LNKVEEKGIQLPIQAGIMPVTNKKQIERIVALSGANLPVKFKKIMEKYEHNKEALRDAGI 248 Query: 255 NIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 A+D + L G + H YT+N ++ ++ ++ Sbjct: 249 AYALDQIVDLISTGARGIHLYTMNNPYIARSVTESI 284 >UniRef50_UPI0001C36AF7 5,10-methylenetetrahydrofolate reductase n=1 Tax=Clostridium hathewayi DSM 13479 RepID=UPI0001C36AF7 Length = 293 Score = 287 bits (735), Expect = 3e-76, Method: Composition-based stats. Identities = 89/276 (32%), Positives = 142/276 (51%), Gaps = 3/276 (1%) Query: 18 EVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE-RDRTHSIIKG 76 E + +SFE FPP+ + + ++ L L P ++SVT+GA G R+RT + K Sbjct: 14 ETPSKKTLSFEIFPPKKDSELKNIDKTLSVLCELNPDYISVTFGAGGGANRNRTIELAKR 73 Query: 77 IKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP--EMYASD 134 IK +E HLTC+ E+ AR N G+++++ALRGD P + ++ASD Sbjct: 74 IKQEYHVEPVVHLTCLHYDKAEIDEFARVLTNAGLQNVLALRGDKNPNMREKESFLHASD 133 Query: 135 LVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 L+ +K+ DF A YPE HPE++ ++ +LK KV+AGA ++Q FD ++ RF Sbjct: 134 LIAYMKDKWDFCFLGACYPECHPESEDKVCEIKHLKAKVNAGAEVLLSQLCFDNHAFFRF 193 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGA 254 ++ C A I +IPGI+PV N Q K+ M P ++ + + E G Sbjct: 194 QEACRIADIQAPVIPGIMPVINAAQIKRMITMCGATFPVRFQKIIQAYESNKEALFDAGM 253 Query: 255 NIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + A+ + L V+ H YT+N ++ IC + Sbjct: 254 SYALSQIIDLLVSDVEGIHLYTMNNPLVARRICEGI 289 >UniRef50_D1ZNB9 Methylenetetrahydrofolate reductase n=1 Tax=Sordaria macrospora RepID=D1ZNB9_SORMA Length = 758 Score = 286 bits (733), Expect = 5e-76, Method: Composition-based stats. Identities = 93/305 (30%), Positives = 148/305 (48%), Gaps = 29/305 (9%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSS-LKPKFVSVTYGANSGERDRTHSIIKGI 77 Q S EFFPP+T+ L + ++R++ L+P FV+VT+GA ++ + + Sbjct: 88 TARQHYFSLEFFPPKTAMGFANLRDRLERMARGLRPLFVNVTWGAGGSTAQKSLELAEIC 147 Query: 78 KDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS------------ 125 + GL HLTC + + L D GIR+I+ALRGD P + Sbjct: 148 QRELGLTTCLHLTCTNMSRRLLDKTLEDAKVLGIRNILALRGDPPRAAEYHDENDPEPTD 207 Query: 126 GKPEMYASDLVTLLKEVAD--FDISVAAYPEV-----HPEAKSAQADLLNLKRKVDAGAN 178 + +A+DLV +K+ F I VAAYPE HP +S + DL L KV AGA+ Sbjct: 208 DEEFSWAADLVRYIKKNHGDYFCIGVAAYPEGHADQSHPREQSLEHDLPYLVEKVQAGAD 267 Query: 179 RAITQFFFDVESYLRFRDRCV----SAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAW 234 +TQ FFD+++Y F + A DV IIPG++P+ +++ K+ +++ +IP Sbjct: 268 FIMTQLFFDIDAYEHFENTLRGHPSGAFKDVLIIPGLMPIQSYQMIKRTTKLSHAKIPPA 327 Query: 235 MAQMFDGLDDDAETRKLVGANIAMDMVKILSR-----EGVKDFHFYTLNRAEMSYAICHT 289 + D + D E K+ G I ++++ + + FHFYTLN + I Sbjct: 328 LMARLDAVKGDDEKVKMEGVAIVSEIIERIKEIKSRTHTPRGFHFYTLNLEKAVAFIAEG 387 Query: 290 LGVRP 294 + P Sbjct: 388 TNLIP 392 >UniRef50_C7N1R9 Methylenetetrahydrofolate reductase n=2 Tax=Coriobacteriaceae RepID=C7N1R9_SLAHD Length = 286 Score = 286 bits (733), Expect = 5e-76, Method: Composition-based stats. Identities = 101/272 (37%), Positives = 142/272 (52%), Gaps = 3/272 (1%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANS-GERDRTHSIIKGIKD 79 G+I VSFE FPP+ + + L+ L P FVSVTY A G +RT + K +D Sbjct: 10 GKIPVSFETFPPKGEMPVEEARGLMAGLAPLNPAFVSVTYSAGGAGNSERTVDVAKMGQD 69 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP-EMYASDLVTL 138 GL HLTC+ AT + + GI +++ALRGD PG YA DL+ L Sbjct: 70 EFGLTCMAHLTCMGATKESVAREFERMREAGIENVLALRGDKVPGRDADVFHYAKDLIPL 129 Query: 139 LKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRC 198 +E A F + AAYPE H + A + +LK K DAGA +TQ FF+ + LRF D Sbjct: 130 ARE-AGFCVGAAAYPEGHVDCLDFDASIRHLKEKQDAGAEFFVTQLFFENDVALRFLDAA 188 Query: 199 VSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAM 258 SAGI V I GI+P + Q + M +P+ + ++ + +DD E+ + G A Sbjct: 189 RSAGITVPITFGIMPFMSKAQLTRMIFMCGASLPSPIIKLLNHYEDDEESLRQAGIEYAC 248 Query: 259 DMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + L REGV H YT+NRA+++ A+ L Sbjct: 249 NQFVELGREGVDGLHVYTMNRADIASAVMEAL 280 >UniRef50_Q2HBA5 Methylenetetrahydrofolate reductase n=2 Tax=Leotiomyceta RepID=Q2HBA5_CHAGB Length = 643 Score = 286 bits (733), Expect = 5e-76, Method: Composition-based stats. Identities = 95/314 (30%), Positives = 152/314 (48%), Gaps = 30/314 (9%) Query: 10 DALNQSLAEV-QGQINVSFEFFPPRTSEMEQTLWNSIDRLS-SLKPKFVSVTYGANSGER 67 D + +A + GQ S EFFPP+T+ L + +DR++ +L+P FV+VT+GA Sbjct: 21 DKITDKIAALPAGQDYFSLEFFPPKTAMGFSNLRSRLDRMARALRPLFVNVTWGAGGSTA 80 Query: 68 DRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK 127 ++ + + + GL HLTC + + + D GIR+I+ALRGD P + Sbjct: 81 TKSLELAEICQRELGLTTCLHLTCTNMSRRLIDKALDDAKALGIRNILALRGDPPRRAEY 140 Query: 128 PEMY------------ASDLVTLLKEVAD--FDISVAAYPEV-----HPEAKSAQADLLN 168 + A DLV +++ F I VAAYPE HP +S + DL Sbjct: 141 RDANEPEPEEEEEFSWAVDLVRYIRKTHGDYFCIGVAAYPEGHADESHPLGQSLEHDLPY 200 Query: 169 LKRKVDAGANRAITQFFFDVESYLRFRDRCVS----AGIDVEIIPGILPVSNFKQAKKFA 224 L K AGA+ +TQ FFDVE+Y F A ++ I+PG++P+ +++ K+ Sbjct: 201 LVEKTQAGADFIMTQLFFDVEAYNHFEKTLREHPSGAFKNITILPGLMPIQSYQMIKRTT 260 Query: 225 DMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSR-----EGVKDFHFYTLNR 279 +++ IP + D + D E K VG +I ++V+ + + + FHFYTLN Sbjct: 261 KLSHANIPDSLMARLDAVKGDDEKVKEVGVDILSEIVEQIKEVKSRTDEPRGFHFYTLNL 320 Query: 280 AEMSYAICHTLGVR 293 + I G+ Sbjct: 321 EKAVSFIVERTGLI 334 >UniRef50_A1W0I6 Methylenetetrahydrofolate reductase n=14 Tax=Campylobacter RepID=A1W0I6_CAMJJ Length = 282 Score = 285 bits (731), Expect = 8e-76, Method: Composition-based stats. Identities = 88/271 (32%), Positives = 143/271 (52%), Gaps = 3/271 (1%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG-ERDRTHSIIKGIKDRTG 82 + SFE FPPR E + L +D L L P F+SVT+GA T + I++ Sbjct: 3 SFSFEVFPPRKDENIKNLHAILDDLGQLSPNFISVTFGAGGSINSQNTLEVASLIQEEYQ 62 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG--SGKPEMYASDLVTLLK 140 + + HL CI ++ +++ I + + I+ALRGD+ K YASDL++ +K Sbjct: 63 IPSIVHLPCIHSSKEKITQILQKCKEKNLNQILALRGDICENLEKSKDFSYASDLISFIK 122 Query: 141 EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVS 200 + F+I A YPE H E+K+ D+ LK KV+AG ++ ITQ F+D E + F+ C Sbjct: 123 KQEYFEIYAACYPEKHNESKNFIEDIHYLKTKVNAGTDKLITQLFYDNEDFYTFKQNCAL 182 Query: 201 AGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDM 260 AGID+ I GI+P++N +Q K + + +IP ++ + +++A + G A D Sbjct: 183 AGIDIPIYAGIMPITNKRQVLKISQLCGAKIPPKFVKILEKYENNALALEDAGIAYACDQ 242 Query: 261 VKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 + L GV H YT+N+++ + I + Sbjct: 243 IVDLITSGVDGIHLYTMNKSKAAIKIYEAVK 273 >UniRef50_C6PS47 Methylenetetrahydrofolate reductase n=1 Tax=Clostridium carboxidivorans P7 RepID=C6PS47_9CLOT Length = 285 Score = 285 bits (731), Expect = 8e-76, Method: Composition-based stats. Identities = 84/279 (30%), Positives = 140/279 (50%), Gaps = 4/279 (1%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 ++ +++ SFE FPP++ + + L ++++ L P F+S TYGA R I K IK Sbjct: 7 MKKKMSFSFEVFPPKSDKPIEPLLDTLEHLYEFNPDFISCTYGAGGTNAGRNMEICKAIK 66 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK---PEMYASDL 135 D H TCI T ++++ + Y + G+ HI+ALRGDLP G YA++L Sbjct: 67 DSGKSIPVTHYTCIGNTKEKMKQELQRYLDMGVDHILALRGDLPKGWEGTRGDFNYANEL 126 Query: 136 VTLLK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 V +K F I+V+ PE H E+ S D+ +L+ K DAGA+ +TQ DV+ Y + Sbjct: 127 VQYIKSNFPKFTIAVSGNPEKHFESYSFDEDITHLRIKQDAGADYIMTQLCHDVDQYCWW 186 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGA 254 ++ AG+ + I G++P+ + + A IP +A++ D+ E K G Sbjct: 187 VEKIRKAGVSMPIDVGVMPILSKDPTIRMAVSNGSSIPRDLAEIIARYGDNPEDFKKAGK 246 Query: 255 NIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 + + G+ H Y+LN+ + I +G+R Sbjct: 247 EYSAKQIFKFINAGIDGLHIYSLNKWQDVTDIIKDVGIR 285 >UniRef50_P46151 Methylenetetrahydrofolate reductase 1 n=10 Tax=Saccharomycetaceae RepID=MTHR1_YEAST Length = 657 Score = 285 bits (731), Expect = 9e-76, Method: Composition-based stats. Identities = 89/295 (30%), Positives = 146/295 (49%), Gaps = 21/295 (7%) Query: 14 QSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSI 73 + L + +S EFFPP+T + L + R+++L P F++VT+GA ++T ++ Sbjct: 4 RDLYHARASPFISLEFFPPKTELGTRNLMERMHRMTALDPLFITVTWGAGGTTAEKTLTL 63 Query: 74 IKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG------- 126 + + HLTC + + +N GIR+I+ALRGD P G Sbjct: 64 ASLAQQTLNIPVCMHLTCTNTEKAIIDDALDRCYNAGIRNILALRGDPPIGEDWLDSQSN 123 Query: 127 -KPEMYASDLVTLLKEVAD--FDISVAAYPEVHPEAK------SAQADLLNLKRKVDAGA 177 P YA DLV +K+ F + VAAYPE H E + DL+ LK KV+AGA Sbjct: 124 ESPFKYAVDLVRYIKQSYGDKFCVGVAAYPEGHCEGEAEGHEQDPLKDLVYLKEKVEAGA 183 Query: 178 NRAITQFFFDVESYLRFRDRCVSA-GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMA 236 + ITQ F+DVE +L F D+ + PG++P++++ + A +++ IP + Sbjct: 184 DFVITQLFYDVEKFLTFEMLFRERISQDLPLFPGLMPINSYLLFHRAAKLSHASIPPAIL 243 Query: 237 QMFDG-LDDDAETRKLVGANIAMDMVKILSRE---GVKDFHFYTLNRAEMSYAIC 287 F + D K +G +I +++++ + + +K FHFYTLN + I Sbjct: 244 SRFPPEIQSDDNAVKSIGVDILIELIQEIYQRTSGRIKGFHFYTLNLEKAIAQIV 298 >UniRef50_C4XPB4 Methylenetetrahydrofolate reductase n=11 Tax=Deltaproteobacteria RepID=C4XPB4_DESMR Length = 330 Score = 285 bits (731), Expect = 9e-76, Method: Composition-based stats. Identities = 98/280 (35%), Positives = 140/280 (50%), Gaps = 9/280 (3%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 + VS EFFPP+ E + +++L ++P FVSVTYGA T I+ +K Sbjct: 49 ARRPFVSLEFFPPKEREAWDGFFGVVEKLIPVRPLFVSVTYGAGGSTHAHTLEIVSRLKT 108 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS------GKPEMYAS 133 GLE HLTC+ A+ D++R G+ +++ALRGD P G + +AS Sbjct: 109 AYGLEPMAHLTCVGASKDKIRGFLGALAQAGVDNVLALRGDPPKGQETFVPDSEDFQHAS 168 Query: 134 DLVTLLK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYL 192 DLV ++ E + + VA YPE HPEA S Q DL +L+ K+ G + A+TQ FFD + Y Sbjct: 169 DLVAFIRAEYPNLCLGVAGYPECHPEAVSPQEDLEHLRHKLALGGSFAVTQLFFDNDRYF 228 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFD--GLDDDAETRK 250 F R +AGID ++PG+LPV + K+FA + +P + Sbjct: 229 DFVARARAAGIDAPMVPGVLPVLSLASIKRFAALCGASLPPAYMAELEAADAAGGNAAVA 288 Query: 251 LVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 VG A + L R G H YTLN+AE +I L Sbjct: 289 EVGIAYARKQAQDLLRRGAPGVHLYTLNKAEAVLSIVSGL 328 >UniRef50_C9RM26 Methylenetetrahydrofolate reductase n=23 Tax=Bacteria RepID=C9RM26_FIBSS Length = 296 Score = 285 bits (729), Expect = 1e-75, Method: Composition-based stats. Identities = 86/278 (30%), Positives = 141/278 (50%), Gaps = 7/278 (2%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 Q ++++SFE FPP+ + + + + ++ L P F+SVTYGA G T I K +K Sbjct: 9 QDKMSLSFEVFPPKKETSFENVKAATEAIAKLNPAFMSVTYGAGGGVSQYTLEIAKNLKY 68 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG------SGKPEMYAS 133 + HLTCI +T + + D GI++++ALRGDL P +A Sbjct: 69 NFNIPMLAHLTCISSTKETIHQRIEDMKAAGIKNVMALRGDLTPELIANGRGDCDYHHAV 128 Query: 134 DLVTLLKEVA-DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYL 192 +L+ LK DF I A YPE HPE+ + D+ +LK KV+AGA+ TQ FD + Sbjct: 129 ELIRELKAADADFCIGAACYPEKHPESPNQAEDIKHLKEKVEAGADFLTTQMVFDNNLFF 188 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV 252 F + AG++ ++PGI+P++N Q ++ ++ +P + D D E K Sbjct: 189 SFLYKLRDAGVNCPVLPGIMPITNANQVERAIKLSGSFMPQHFKSLVDKFGSDPEAMKQA 248 Query: 253 GANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 G A D + L G+ + H Y++N+ +++ I + Sbjct: 249 GIIYATDQIIDLYANGITNVHVYSMNKPDVAEGILKNV 286 >UniRef50_Q28TL9 Methylenetetrahydrofolate reductase n=3 Tax=Rhodobacteraceae RepID=Q28TL9_JANSC Length = 288 Score = 284 bits (728), Expect = 2e-75, Method: Composition-based stats. Identities = 123/280 (43%), Positives = 160/280 (57%), Gaps = 7/280 (2%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 NVSFEFFPP++ E LW ++ L+ L P FVSVTYGA R TH + I G Sbjct: 4 PNVSFEFFPPKSLEGSFKLWETLGVLAPLDPTFVSVTYGAGGTTRKLTHEAVTAINANFG 63 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY------ASDLV 136 + A HLTC+DAT E IA Y GI IVALRGD P G+ + + + DLV Sbjct: 64 VPVAAHLTCVDATRAETLEIADQYAQAGITQIVALRGDPPKGTATFQAHPDGFGSSEDLV 123 Query: 137 TLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRD 196 L + FDI V AYP+ HPEA S QA + LK K+DAGA AITQFFF+ +++ RFRD Sbjct: 124 AALAKTGKFDIRVGAYPDPHPEAASMQACVDYLKAKIDAGATSAITQFFFEADTFFRFRD 183 Query: 197 RCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANI 256 C +AGI I+PGILP+ ++ +A++FA IP W+ + D L+ I Sbjct: 184 ACAAAGITAPILPGILPIEDWSRARRFATACGAVIPTWLDDAYTSAIRDGRE-DLLSTAI 242 Query: 257 AMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 ++ L GV D HFYTLNR E++ +C LGV P + Sbjct: 243 CTELCTDLIEGGVDDLHFYTLNRPELTRDVCAALGVAPNV 282 >UniRef50_D0RN29 Methylenetetrahydrofolate reductase n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RN29_9RICK Length = 298 Score = 284 bits (727), Expect = 2e-75, Method: Composition-based stats. Identities = 129/279 (46%), Positives = 193/279 (69%), Gaps = 6/279 (2%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 ++ ++ SFEFFP + +E E W S+ +L S P+F SVT+GA GER +T S +K IK Sbjct: 1 MKEELKFSFEFFPSKNAEDEVAAWKSLKKLESFDPQFYSVTFGAGGGERIKTDSFVKKIK 60 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG----KPEMY--A 132 + + A HLTC+D + DE+ IA +++ GI+ IVALRGD+ P+ Y A Sbjct: 61 KESNVPVAGHLTCVDMSKDEINDIAVNWFEKGIKRIVALRGDVRKPGEQYKPHPDGYKNA 120 Query: 133 SDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYL 192 +D+ LK++A+FDISVA YPE+HP++K+ + DL NLKRKVDAGA+R ITQFFFD +L Sbjct: 121 ADMTAGLKKLANFDISVAGYPEIHPDSKNKELDLDNLKRKVDAGADRIITQFFFDENIFL 180 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV 252 +FRD GI ++++PGI+P+ N+K+ K F++ +PAW+ + F+G +D+ + +K++ Sbjct: 181 KFRDDIAKQGIKIQLLPGIMPIQNYKRVKNFSNKCGTSVPAWIEKEFEGSEDNPDVQKMI 240 Query: 253 GANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 G++IA D+VK L +EGV +FHFYTLN+ E+SYA+C L Sbjct: 241 GSSIATDLVKKLQKEGVNEFHFYTLNKYELSYAVCSRLK 279 >UniRef50_Q30YC4 Methylenetetrahydrofolate reductase n=5 Tax=Desulfovibrio RepID=Q30YC4_DESDG Length = 316 Score = 284 bits (726), Expect = 3e-75, Method: Composition-based stats. Identities = 97/301 (32%), Positives = 144/301 (47%), Gaps = 11/301 (3%) Query: 2 SFFHASQRDALNQSLAEVQGQ---INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSV 58 + H + + ++ GQ S E+FPP+ EM + ++ RL +L P F SV Sbjct: 13 ATAHLRSNKDSDVKIKDLIGQHDGPFYSLEYFPPKNPEMWPKFFANVGRLMALNPVFCSV 72 Query: 59 TYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALR 118 TYGA G +D T I + K LE PHLTC+ AT D++R + G+ +++ALR Sbjct: 73 TYGAGGGTQDNTFEITRRFKQDLDLEPMPHLTCVGATKDKIRGFVSQLRDIGVDNVLALR 132 Query: 119 GDLPPGS-----GKPEMYASDLVTLLK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRK 172 GD P + +ASDLV + E + + VA YP HPE+ S DL K K Sbjct: 133 GDAPADAGFSWDDGEFRHASDLVEFVNAEFPEMCVGVAGYPTAHPESASFAEDLHWTKAK 192 Query: 173 VDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIP 232 +DAG++ + Q FDV Y F + + G+ ++PGILP+ + + ++ + IP Sbjct: 193 IDAGSDFIVCQLLFDVREYFHFVAQLRAMGVTSPVLPGILPIQSLESVRRILSLCGANIP 252 Query: 233 AWMAQMFDG--LDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + A K +G A DM++ L GV H YTLN+AE I Sbjct: 253 GRFYLQLEEADAKGGAAAVKELGTKFAADMIRRLVDGGVPGVHLYTLNQAETCLRIAEMA 312 Query: 291 G 291 G Sbjct: 313 G 313 >UniRef50_B3W8E2 Methylenetetrahydrofolate reductase n=15 Tax=Bacteria RepID=B3W8E2_LACCB Length = 290 Score = 282 bits (722), Expect = 1e-74, Method: Composition-based stats. Identities = 96/273 (35%), Positives = 141/273 (51%), Gaps = 6/273 (2%) Query: 20 QGQINVSFEFFPPRTSEMEQTL---WNSIDRLSSLKPKFVSVTYGANSG-ERDRTHSIIK 75 + +SFE FPPR + L N++D + P FVSVT+GAN T + K Sbjct: 8 KDHQVISFEVFPPRKNASNIALTPILNTLDAVKEADPDFVSVTFGANGNKPHMGTLEVAK 67 Query: 76 GIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS--GKPEMYAS 133 IKD +E HL T +++ R + + GI +I+ALRGD+P YA Sbjct: 68 LIKDEFDMEPVAHLPAAQLTREQVDAELRGFQDAGIDNILALRGDIPKSGRVSNDFPYAC 127 Query: 134 DLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLR 193 DL+ + +V DF++ A YPE HPE+ +D+ +LK KVD+GA++ I+Q FFD + + R Sbjct: 128 DLIEHIHQVGDFNVVAACYPEKHPESPDVVSDIHHLKEKVDSGASQLISQLFFDNQVFYR 187 Query: 194 FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVG 253 FR+R AGI+V I GI+PV N Q ++ A M V +P M + E + G Sbjct: 188 FRERAQLAGINVPIEAGIMPVINEHQIERMATMAGVNLPPKFVAMMQHFSGNKEAMRDAG 247 Query: 254 ANIAMDMVKILSREGVKDFHFYTLNRAEMSYAI 286 A+D + L GV H YT++ + I Sbjct: 248 IAYAIDQIVDLLVHGVDGIHIYTMDNPTVVKRI 280 >UniRef50_Q6CEM7 Methylenetetrahydrofolate reductase n=1 Tax=Yarrowia lipolytica RepID=Q6CEM7_YARLI Length = 625 Score = 282 bits (721), Expect = 1e-74, Method: Composition-based stats. Identities = 82/303 (27%), Positives = 139/303 (45%), Gaps = 22/303 (7%) Query: 10 DALNQSLAEVQ-GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERD 68 + + +A ++ + S EFFPP+T + R+++LKP F+++T+GA Sbjct: 2 STITKLIAGLKPDEKFFSLEFFPPKTQNGMANFRARLARMAALKPLFITITWGAGGSTAK 61 Query: 69 RTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP 128 ++ I + GL+ HLTC + P + GI +I+ALRGD P G Sbjct: 62 KSLDIASECQS-MGLDVCLHLTCTNMDPALIDQALEAASKAGICNILALRGDPPRGEEYW 120 Query: 129 ------EMYASDLVTLLKEVAD--FDISVAAYPEVHPEA-----KSAQADLLNLKRKVDA 175 +A+DLV +K+ F + VA YPE H + + DL LK KV+A Sbjct: 121 QPASPEFQHAADLVKYIKKKHGNKFCVGVAGYPEGHVDGSDASHQDFHHDLPYLKEKVEA 180 Query: 176 GANRAITQFFFDVESYLRFRDRCVSAG---IDVEIIPGILPVSNFKQAKKFADMTNVRIP 232 GA+ ITQ F+D +L + ++ IIPG++P++ + + A +++ +P Sbjct: 181 GADFIITQMFYDDNKFLEYNKAVREFSPLLKNITIIPGLMPINTYTSFVRAARLSHASVP 240 Query: 233 AWMAQMFDGL-DDDAETRKLVGANIAMDMVKILS---REGVKDFHFYTLNRAEMSYAICH 288 + + + + K +G + D+V + + V+ FHFYTLN I Sbjct: 241 PAILDRIQAVPTGNDQQVKDIGVEVVSDIVNDVYTKTNKTVRGFHFYTLNLERSVARILE 300 Query: 289 TLG 291 G Sbjct: 301 RSG 303 >UniRef50_C0WB69 Methylenetetrahydrofolate reductase n=1 Tax=Acidaminococcus sp. D21 RepID=C0WB69_9FIRM Length = 288 Score = 281 bits (720), Expect = 2e-74, Method: Composition-based stats. Identities = 90/275 (32%), Positives = 145/275 (52%), Gaps = 5/275 (1%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 ++ +S E FPP+ Q + + ++ ++SVTYGA ++ +I + + Sbjct: 9 SPKVTISCELFPPKKGTELQNAMDIVHAIAIDGVDYMSVTYGAGGTAVGKSLAIASEV-E 67 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK----PEMYASDL 135 R+G+ A HLTCI A D + + RD GI +++ALRGD P G + +ASDL Sbjct: 68 RSGVPALAHLTCIGAKKDGIARVLRDMKAGGIDNVLALRGDRPQGMDELPESDFPHASDL 127 Query: 136 VTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFR 195 V +KE DF + A YPE HPE+++ DL N+KRKVDAG + +TQ FFD E + F Sbjct: 128 VRFIKETGDFCVGCATYPEGHPESRTLDEDLENMKRKVDAGCDFLVTQMFFDNEMFYNFM 187 Query: 196 DRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGAN 255 R ++ G+ V ++ G++P++N KQ ++ ++ IP+ + + + D E + G Sbjct: 188 YRLLAKGVRVPVVAGVMPITNAKQVERIFTLSGTPIPSKLRAVVERFGDHPEALRQAGMA 247 Query: 256 IAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + L G H YT+N+ E+ I TL Sbjct: 248 YTTGQIMDLIANGFNHIHVYTMNKPEVIGGIRRTL 282 >UniRef50_A9UZU5 Methylenetetrahydrofolate reductase n=1 Tax=Monosiga brevicollis RepID=A9UZU5_MONBE Length = 332 Score = 278 bits (711), Expect = 2e-73, Method: Composition-based stats. Identities = 97/322 (30%), Positives = 144/322 (44%), Gaps = 40/322 (12%) Query: 11 ALNQSLAEV--QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERD 68 ++ L E+ +G+ VSFEFFPPRT + +L + I R + +P F+ +T+GA D Sbjct: 5 KISDRLQELSAKGEKFVSFEFFPPRTDDGVTSLMSRIQRYNDQQPLFMDMTWGAGGSTSD 64 Query: 69 RTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP 128 T + + G A HLTC + +++ + + GIR+IVALRGD P G Sbjct: 65 LTLDLCTRMVKECGANANMHLTCTNMPSEKIDIALKGARDAGIRNIVALRGDPPAGEEAW 124 Query: 129 EM------YASDLVTLLKEVAD--FDISVAAYPEVHPEA--------------------- 159 E A DLV +++ F I+V+ YPE HP A Sbjct: 125 EAVEGGYSCALDLVKHIRKEHGDFFSIAVSGYPEGHPNAITKVQDEAELTESERERVIEM 184 Query: 160 ---------KSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPG 210 Q ++ LK KVDAGA+ ITQ FD Y F C + GI++ ++PG Sbjct: 185 EDGLYVCRDGDFQKEMEYLKAKVDAGADLIITQMVFDAPVYGAFLKACKAYGINIPVVPG 244 Query: 211 ILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVK 270 I+ + N K+ R PA + + DD E + V + + L G Sbjct: 245 IMCIQNAGGFKRMTAFCKSRTPAALRAAVEAAGDDKEAIRKVAVEHGAQLCRDLQAAGAP 304 Query: 271 DFHFYTLNRAEMSYAICHTLGV 292 HFYTLN +++ AI L + Sbjct: 305 GLHFYTLNLEKVTLAILDALNL 326 >UniRef50_A8ZV44 Methylenetetrahydrofolate reductase n=2 Tax=Desulfobacteraceae RepID=A8ZV44_DESOH Length = 292 Score = 278 bits (711), Expect = 2e-73, Method: Composition-based stats. Identities = 96/281 (34%), Positives = 144/281 (51%), Gaps = 6/281 (2%) Query: 16 LAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIK 75 + E + VSFEFFPPR + + T ID L+ LKP ++SVT+GA +D ++ +K Sbjct: 6 VYEKRKGPVVSFEFFPPRDEKAQGTFDAVIDELTPLKPDYLSVTFGAGGSTKDGSYQTVK 65 Query: 76 GIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG-----KPEM 130 + L ++ +PD + + Y GI I +RGD P + M Sbjct: 66 HLTADANLPVVAYVAGYGLSPDTIVNVLDRYRAIGIETIFVIRGDQPREPDFVSHPESFM 125 Query: 131 YASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES 190 YASDL+ + E DF + A YPE H +A+S + D+ LK KVD GA +TQ+F+D Sbjct: 126 YASDLIAFIAEQYDFSLGCAGYPEGHLQAESLEKDIEYLKLKVDNGARYVVTQYFYDNTF 185 Query: 191 YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQ-MFDGLDDDAETR 249 Y + ++C +AGI V IIPGI+PV K + + + IPA M + D D A+ Sbjct: 186 YFDYVEKCRAAGITVPIIPGIMPVYTLKMTRMLSKVCGSSIPASMETALADLADAPADRV 245 Query: 250 KLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 G A++ + L +GV HFYT++R+ + I L Sbjct: 246 VDFGIEKAVEQCRGLLEQGVPGLHFYTMDRSRSTREILTRL 286 >UniRef50_A4E8J9 Methylenetetrahydrofolate reductase n=1 Tax=Collinsella aerofaciens ATCC 25986 RepID=A4E8J9_9ACTN Length = 290 Score = 278 bits (711), Expect = 2e-73, Method: Composition-based stats. Identities = 91/282 (32%), Positives = 132/282 (46%), Gaps = 8/282 (2%) Query: 17 AEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG-ERDRTHSIIK 75 A QG +SFE FPP+ T L L P FVSVT A T I Sbjct: 10 AASQGTAPISFEMFPPKGELTLDTAREVAGNLCKLSPSFVSVTCSAGGSGNGAATAPIAH 69 Query: 76 GIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE------ 129 I + HLTC+ + ++ +Y G+ +I+ALRGDLP G+ + + Sbjct: 70 MITSEFDTPSVAHLTCVGRSHADIAAKIDEYRTAGVENILALRGDLPAGATEDDKPASDY 129 Query: 130 MYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVE 189 YA DL+ L + A F + AAYPE H + + +LK+K DAGA+ +TQ FFD E Sbjct: 130 AYARDLIPELVD-AGFCVGAAAYPEGHIACEDLNLSVEHLKQKQDAGASFFVTQLFFDNE 188 Query: 190 SYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETR 249 + RFR+ AGI V I GI+P Q + M +P+ + ++ ++D E+ Sbjct: 189 CFYRFRELADKAGITVPITAGIMPFMGKSQISRMVFMCGASLPSPVIKILAKYENDPESL 248 Query: 250 KLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 + G + A + L G H YT+NR ++ I LG Sbjct: 249 QAAGVDYAARQLCDLKEHGADGLHLYTMNRPAIAATIMERLG 290 >UniRef50_Q0FF75 Methylenetetrahydrofolate reductase n=1 Tax=Rhodobacterales bacterium HTCC2255 RepID=Q0FF75_9RHOB Length = 293 Score = 277 bits (710), Expect = 2e-73, Method: Composition-based stats. Identities = 116/277 (41%), Positives = 163/277 (58%), Gaps = 7/277 (2%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 +SFE FPPR + LW +I+ L L P F+SVTYGA+ R+ T S + I Sbjct: 6 KDFGLSFEIFPPRNLKASFKLWRTIEVLEKLNPNFISVTYGADGSTRELTQSAVSVIAKE 65 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYASD 134 ++ A HLTC+ ++ E+ IA +Y G R IVALRGD P G + + Sbjct: 66 YNIDVAGHLTCVGSSKKEIMDIALEYGKAGARKIVALRGDSPEDQGSENHETDNFSSSVE 125 Query: 135 LVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 L+ LK+ +F++ VAAYP VHP A+S ++DL LK K DAGA+ AITQFFFD E +LRF Sbjct: 126 LIASLKKNTNFELYVAAYPNVHPNAQSEKSDLDVLKAKFDAGADSAITQFFFDKEDFLRF 185 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGA 254 RD+C +AGI IIPGILPV N+ + K FA + P WM++ ++ ++ E L+ Sbjct: 186 RDKCNAAGIYQNIIPGILPVENWSKTKIFAKRCGMDAPQWMSKAYENCKNN-EEHDLLSQ 244 Query: 255 NIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 + +M L +EGV + HFYTLN +++ +C LG Sbjct: 245 ALCTEMCNELMQEGVNNLHFYTLNDPKLTQKVCEALG 281 >UniRef50_C5L500 Methylenetetrahydrofolate reductase n=2 Tax=Perkinsus marinus ATCC 50983 RepID=C5L500_9ALVE Length = 631 Score = 277 bits (709), Expect = 4e-73, Method: Composition-based stats. Identities = 89/270 (32%), Positives = 132/270 (48%), Gaps = 16/270 (5%) Query: 37 MEQTLWNSIDRLSSLKPKFVSVTYGANSGERD--RTHSIIKGIKDRTGLEAAPHLTCIDA 94 Q L+ +DR++ L P ++ VT+GA +T I + GL+ HLTC Sbjct: 2 GVQNLYERLDRMAELGPMWIDVTWGAGGSSSSSNKTFEICRNALTYHGLDVMMHLTCTQQ 61 Query: 95 TPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYASDLVTLLKEVAD--FD 146 + +E+ + GIR+I+ALRGD P S + +A DLV ++ F Sbjct: 62 SVEEIDEVLDKCKEVGIRNILALRGDAPTQSSEWRACQGGFSHAVDLVRHIRGKYGDYFC 121 Query: 147 ISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVE 206 I+VA YPE H EA+S + DL++LK KVDAGA+ ITQ F+D E + +F GI V Sbjct: 122 IAVAGYPEGHLEAESIEEDLVHLKEKVDAGADLIITQLFYDTEVFFKFVAAVRKLGIQVP 181 Query: 207 IIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSR 266 I PGI+P+ ++ KK + ++P +A + + D + K +G I + M + Sbjct: 182 IFPGIMPIQSYSGFKKMTEFCKTKVPRAIADQLEQVKGDDQRVKDLGVEICVAMCSQIMS 241 Query: 267 EGVK------DFHFYTLNRAEMSYAICHTL 290 GV HFYTLN I L Sbjct: 242 YGVDHTHSSGGLHFYTLNLESSVCRIIERL 271 >UniRef50_C0EZI4 Methylenetetrahydrofolate reductase n=1 Tax=Eubacterium hallii DSM 3353 RepID=C0EZI4_9FIRM Length = 288 Score = 276 bits (707), Expect = 6e-73, Method: Composition-based stats. Identities = 88/287 (30%), Positives = 150/287 (52%), Gaps = 7/287 (2%) Query: 11 ALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRT 70 + + ++ +++SFE FPP+ E L+ ++D L L P+F+S TYGA +T Sbjct: 3 TMQTNPQDILKTLSLSFEVFPPKKWEDFPGLYETLDELKGLHPEFISCTYGAGGSNSKKT 62 Query: 71 HSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM 130 I I++ G+ + HLTC T D+L + ++ N GI ++ALRGD P + + Sbjct: 63 AEIASHIENELGIRSIAHLTCAALTEDKLLSTIENFKNAGIHSVLALRGDKPFDMSEEDF 122 Query: 131 ------YASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQF 184 + S+++ +LK+ A F ++ A YPE H EA S + DL LK KV+ GA+ I+Q Sbjct: 123 ANRQYKHPSEIIPILKK-AGFRVAAACYPEKHYEAPSMEEDLHWLKHKVEQGADALISQL 181 Query: 185 FFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDD 244 FFD +++ RF D GI V I GI+P+++ K +++ IP ++ + + Sbjct: 182 FFDNDAFYRFMDAADQKGITVPIHAGIMPITSAKMINTTINLSGASIPKALSDLIATYGE 241 Query: 245 DAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 + + G A + L+ +G+ H YT+N +E + IC + Sbjct: 242 NPSDMRKAGIEYAARQINDLAEQGMHYVHIYTMNHSETAKEICGLIK 288 >UniRef50_B8BVS6 Methylenetetrahydrofolate reductase n=1 Tax=Thalassiosira pseudonana RepID=B8BVS6_THAPS Length = 383 Score = 276 bits (707), Expect = 6e-73, Method: Composition-based stats. Identities = 99/320 (30%), Positives = 148/320 (46%), Gaps = 25/320 (7%) Query: 1 MSFFHASQRDALNQSLAEVQGQIN-VSFEFFPPRTSEMEQTLWNSIDR-LSSLKPKFVSV 58 M+ Q D L + +I VS E+FPPRT + + L +DR L + + + Sbjct: 1 MNGHTERQPDPKIIDLLQRDTEIAHVSLEYFPPRTDQGVKNLHARMDRMLVNTNALYTDM 60 Query: 59 TYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPD-----ELRTIARDYWNNGIRH 113 T+GA D + + + HLTC + D + + ++ GIR+ Sbjct: 61 TWGAGGSTADLSLELALHAHKTGHVSNM-HLTCTNMEKDGDPVKAVHDALQQAYDGGIRN 119 Query: 114 IVALRGDLPPGSGKP------EMYASDLVTLLKEVAD--FDISVAAYPEVHPEAKS---- 161 IVALRGD P G + A DLV +++ F ISVA YPE HP S Sbjct: 120 IVALRGDPPEGEKEWTATEGGFSCALDLVKYIRKTFGDKFGISVAGYPEGHPNRISQLSE 179 Query: 162 -----AQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSN 216 + ++ LK KVDAG + ITQ FFD E + F + C + GI ++PG++ ++ Sbjct: 180 EEDEDYKKEMDYLKEKVDAGGDFIITQMFFDAEVFKTFVNDCRTWGITCPVVPGLMCINA 239 Query: 217 FKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT 276 + KK R+P + + D + DDA+ K G ++ + L GVK HFYT Sbjct: 240 YPGFKKMTKFCKTRVPKSLEERMDAIKDDADAVKKFGVEFGAEISRNLLDSGVKILHFYT 299 Query: 277 LNRAEMSYAICHTLGVRPGL 296 LN ++ Y I LG+ GL Sbjct: 300 LNLEKVVYGITDELGITSGL 319 >UniRef50_C8W5Z9 Methylenetetrahydrofolate reductase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8W5Z9_DESAS Length = 294 Score = 275 bits (704), Expect = 1e-72, Method: Composition-based stats. Identities = 93/278 (33%), Positives = 146/278 (52%), Gaps = 7/278 (2%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G+ +SFEFFP R + +T +I+ L LKP FVSVT+GA ++ ++ ++K +K Sbjct: 9 TGKPTLSFEFFPARNEKAAETFNQTIEDLVELKPDFVSVTFGAGGSTKEGSYELVKKLKK 68 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG------KPEMYAS 133 LE +L DE+ + Y + GI +I+ALRGD P + + YAS Sbjct: 69 EKELEVVAYLAAFALKKDEINAVLNSYQDLGIENILALRGDPPKDADVTQVSAESFKYAS 128 Query: 134 DLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLR 193 +L + + F + VA YPE H EA S + D+ LK KVD G + I QFF+D + Sbjct: 129 ELAAFIHQNYSFCLGVAGYPEGHIEAPSLKKDIEYLKHKVDQGVDFIIAQFFYDNVCFFD 188 Query: 194 FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGL-DDDAETRKLV 252 FR+RC +GI++ ++PGI+PV + K + A +IP + + L + D + Sbjct: 189 FRERCQKSGINIPVLPGIMPVYSVKMMEMLAGSCGAKIPEKLRKGISELPEGDTKALVDF 248 Query: 253 GANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 G A + L +EG + HFYT++++E + I L Sbjct: 249 GIEYATGQCEELLKEGARGLHFYTMDKSESTVGIVKGL 286 >UniRef50_C7NEN8 Methylenetetrahydrofolate reductase n=8 Tax=Fusobacteriaceae RepID=C7NEN8_LEPBD Length = 291 Score = 271 bits (694), Expect = 2e-71, Method: Composition-based stats. Identities = 91/280 (32%), Positives = 148/280 (52%), Gaps = 10/280 (3%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 + + +SFE FPP + E+ L N L KP F+SVTYGA + T + IK+ Sbjct: 9 KKERLISFEIFPPNKNFSEEKLKNVTAELVEYKPDFISVTYGAGGKTKGGTIEMASHIKN 68 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK------PEMYAS 133 E HLTC+ + E+ ++ + I++I+ALRGD+P G + YAS Sbjct: 69 NLKTEVLAHLTCVGSKKSEIHDYLQEAKSKNIKNILALRGDVPQGETEEIYDKGDYKYAS 128 Query: 134 DLVTLLK---EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES 190 +L++ L+ E DF I A YPE H E DL +LK KV+AG + +Q FFD + Sbjct: 129 ELISDLRKNSEFNDFSIGGAFYPETHYENNDL-VDLFHLKNKVEAGTDFLASQMFFDNDV 187 Query: 191 YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRK 250 +++F+++ I V +I GI+PV+N KQ K+ +++ +P + ++ + D+ E+ K Sbjct: 188 FVKFKEQAEKLDIKVPLIAGIMPVTNAKQIKRIIELSKCSVPEKLDKLLEKYGDNPESMK 247 Query: 251 LVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 G A + + L G+K H YT+N+ E++ I + Sbjct: 248 KAGIMYASEQIIELLAYGIKGIHIYTMNKPEIAKEIMKNI 287 >UniRef50_A8PLM8 Methylenetetrahydrofolate reductase n=1 Tax=Rickettsiella grylli RepID=A8PLM8_9COXI Length = 281 Score = 269 bits (687), Expect = 1e-70, Method: Composition-based stats. Identities = 101/278 (36%), Positives = 164/278 (58%), Gaps = 5/278 (1%) Query: 17 AEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKG 76 ++ + N SFE FPP+T + L+ + LS LKP + S+T+GA + ++ +IK Sbjct: 1 MQLCQKFNFSFEVFPPQTHRGLKNLYATRQELSKLKPNYFSITFGAGGAIQHQSLLVIKQ 60 Query: 77 IKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK--PEMYASD 134 G+ A PH++C++ T L + +Y G++ ++ ++GDLP K YA++ Sbjct: 61 FVKD-GIAATPHISCVNMTYPRLYDLLMEYQQLGVKQLLVIQGDLPKEVPKLSEFNYANE 119 Query: 135 LVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYL 192 L++ ++++ F I VAAYPE HP+A S + D+ N KRK++AGAN AITQFFF+ ++Y Sbjct: 120 LISAIRKITGNYFHIIVAAYPEFHPQAFSPRKDIENFKRKIEAGANSAITQFFFNSDAYF 179 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV 252 RF + C A I + I+PGI P+ N+++ +F+ IP W+ + L +D ++ + V Sbjct: 180 RFIEACEKASIHIPIVPGITPIINYQKLIQFSTACGAEIPLWLRKHLAMLSNDPQSLQEV 239 Query: 253 GANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 G + + L + GVK+FHFYTLNRA +Y I L Sbjct: 240 GIEFVTKLCQHLLQNGVKEFHFYTLNRANPTYRIIENL 277 >UniRef50_Q4P1E8 Methylenetetrahydrofolate reductase n=1 Tax=Ustilago maydis RepID=Q4P1E8_USTMA Length = 684 Score = 268 bits (686), Expect = 1e-70, Method: Composition-based stats. Identities = 87/328 (26%), Positives = 140/328 (42%), Gaps = 50/328 (15%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLS-SLKPKFVSVTYGANSGERDRTHSIIKGI 77 + SFEFFPP+TS+ L+N I R+ +L+P ++ VT+GA ++ + I Sbjct: 34 TRDAPFWSFEFFPPKTSQGLANLYNRIARMHVNLEPSWIHVTWGAGGTTGGKSLELAGRI 93 Query: 78 K--------------------------------------DRTGLEAAPHLTCIDATPDEL 99 + + HLTC + L Sbjct: 94 QKGKLDPDVELVQTEINHIGSGTQQHIENVKGGQEWEQERADPCDVCLHLTCTNVEKSSL 153 Query: 100 RTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYASDLVTLLKEVAD--FDISVAA 151 GI++I+ALRGD P G +A+DLV +++ F I VA Sbjct: 154 DQTLDTAKRLGIKNILALRGDPPRGEEYWIAADKRFQHATDLVRYIRQRHGNYFCIGVAG 213 Query: 152 YPEVHPEAKSAQ--ADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIP 209 YPE H + DL LK K DAGA ITQ F+DV+ +L + C GI + I+P Sbjct: 214 YPEGHADYVDRDVNRDLRYLKDKQDAGAQYIITQLFYDVDRFLEWYRDCREIGITIPILP 273 Query: 210 GILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKIL-SREG 268 GI+P+ N+ ++ ++ V++P + + + D K G ++++ MV + Sbjct: 274 GIMPIQNYSSFRRMTNLCKVQVPQLILDALEPIKSDDAAVKEYGVSLSIHMVGRIFLETD 333 Query: 269 VKDFHFYTLNRAEMSYAICHTLGVRPGL 296 V+ FH +LN + I LG + + Sbjct: 334 VRGFHLCSLNLEKSIERILEGLGWKTDV 361 >UniRef50_Q5M088 Methylenetetrahydrofolate reductase n=47 Tax=Firmicutes RepID=Q5M088_STRT1 Length = 311 Score = 268 bits (686), Expect = 2e-70, Method: Composition-based stats. Identities = 92/294 (31%), Positives = 148/294 (50%), Gaps = 5/294 (1%) Query: 1 MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY 60 + + Q+ + ++SFE FPP + + + ++D + P F+SVT Sbjct: 4 IKMLLSQQKSKTKKVKLMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTA 63 Query: 61 GANSGE-RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRG 119 N ++ T + I++ + HL I + +++ R+ G+ I+ALRG Sbjct: 64 SNNKYNIKETTVPLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRG 123 Query: 120 DLPPGSG--KPEMYASDLVTLLK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAG 176 D+ PG K YA+DL+ +K E +FDI A YPE HP++ + +D+ NLK+KVDAG Sbjct: 124 DIIPGVEPLKDFRYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAG 183 Query: 177 ANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMT-NVRIPAWM 235 + +TQ FFD E + F+D+C AGIDV I GI+P+ N QA + N+ +P Sbjct: 184 CSSLVTQLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKF 243 Query: 236 AQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHT 289 + D + D E+ + G A+D + L + V H YT+N AE + I Sbjct: 244 RAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEA 297 >UniRef50_A6UBB8 Methylenetetrahydrofolate reductase n=45 Tax=Rhizobiales RepID=A6UBB8_SINMW Length = 313 Score = 267 bits (684), Expect = 3e-70, Method: Composition-based stats. Identities = 113/277 (40%), Positives = 161/277 (58%), Gaps = 8/277 (2%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 I SFE+FPP+ EME L+ ++ LS P FV+VTYGA + R+ + +K + Sbjct: 14 IRFSFEYFPPKNDEMEAQLFQTVTALSVFAPAFVTVTYGAGGSTKARSLTTVKRMIGEMA 73 Query: 83 L-EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG-------KPEMYASD 134 + A HLTC+ A ++ + ++ G+RH VALRGD G G A+D Sbjct: 74 IGNTAAHLTCVGAPKADVDAVVDEFVACGVRHFVALRGDPQGGIGSVYEPFPGGYENAAD 133 Query: 135 LVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 LV L+ DF+ISV+AYPE HPE+ AD+ LKRKVD GA RA+TQFFFD + + R+ Sbjct: 134 LVKALRARGDFEISVSAYPEKHPESSDVAADIDMLKRKVDKGATRALTQFFFDNDDFERY 193 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGA 254 +R AGI + ++PGILP++N Q +KFA + R+P + L+D E R A Sbjct: 194 LERVRRAGIGIPVVPGILPINNLAQVQKFAGLCGARVPESLISRLGPLNDRPEERFREAA 253 Query: 255 NIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 +IA + + L R GV DFH YT+NR ++ A+C +G Sbjct: 254 HIAAEQIADLVRRGVNDFHLYTMNRPQLVTAVCGLIG 290 >UniRef50_C4ZCX7 Methylenetetrahydrofolate reductase n=2 Tax=Firmicutes RepID=C4ZCX7_EUBR3 Length = 288 Score = 267 bits (684), Expect = 3e-70, Method: Composition-based stats. Identities = 85/273 (31%), Positives = 140/273 (51%), Gaps = 5/273 (1%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG-ERDRTHSIIKGIKDRTG 82 ++SFE FPP+ E + + ++ L P+++SVT+GA ++T I K IK++ Sbjct: 13 SLSFEIFPPKKEEDFKNIDEMLEILCDCHPEYISVTFGAGGSSNNNKTIEIAKKIKNQYN 72 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD--LPPGSGKPEMYASDLVTLLK 140 +E HLTC+ E+ R GI +I+ALRGD + + ++ASDL+ +K Sbjct: 73 VEPVVHLTCLCYNKAEIDEFTRQLSYEGIENILALRGDRNPNVPAKEDFLHASDLIKYIK 132 Query: 141 EVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRC 198 + F I+ A YP++HPEA D+ NLK+KVDAGA ++Q FFD +++ F + C Sbjct: 133 DTTGDQFCIAGACYPDIHPEAADKVDDIKNLKKKVDAGAELLLSQLFFDNDTFFNFAEDC 192 Query: 199 VSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAM 258 AGI+V +IPGI+P N Q ++ M + P ++ D+ G + Sbjct: 193 RLAGINVPVIPGIMPCINAAQIQRMVTMCGAKFPEKFQKIVHRYGDNKAALFDAGMSYCE 252 Query: 259 DMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 + L V+ H YT+N ++ + + Sbjct: 253 SQIIELLANDVEGIHLYTMNNVRVAKRLTEGIK 285 >UniRef50_A5EYC8 Methylenetetrahydrofolate reductase n=2 Tax=Cardiobacteriaceae RepID=A5EYC8_DICNV Length = 293 Score = 267 bits (682), Expect = 4e-70, Method: Composition-based stats. Identities = 103/289 (35%), Positives = 159/289 (55%), Gaps = 4/289 (1%) Query: 8 QRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGER 67 R ++ E + +S EFFP T E+ L LS L ++ SVTYGA R Sbjct: 2 SRFPYLVNMIEKSNSLRLSCEFFPAATKIGEKKLAEVRQALSFLNCEYYSVTYGAGGATR 61 Query: 68 DRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK 127 D+T +++K + PH+TC+ + + ++ Y GI+H++ LRGD+P G + Sbjct: 62 DQTIALVKTLCREAERAVMPHITCVASHKRAIASLLAQYQKLGIKHLMLLRGDMPSGIYQ 121 Query: 128 --PEMYASDLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQ 183 M A DLV L+++ I VAAYPE HP+A++ Q DL+N K AGAN A+TQ Sbjct: 122 LGDIMSARDLVRLVRKQWGDSVHIVVAAYPETHPQAQTQQIDLINFYEKCAAGANEAVTQ 181 Query: 184 FFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLD 243 +FF+ ++YLRFRD V G+ + I+PGI+P++N+ + +F+D IP W+ + Sbjct: 182 YFFNGDAYLRFRDDVVKMGVSIPIVPGIMPITNYVRLARFSDNCGTEIPRWIRTRLESYQ 241 Query: 244 DDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 +D+ + GA++ + + L EGV HFYT+NRA+ I LG Sbjct: 242 EDSASLLDFGADVVSQLCQRLVSEGVPGLHFYTMNRADALIEIAKRLGW 290 >UniRef50_B7GRV7 Methylenetetrahydrofolate reductase n=16 Tax=Bifidobacteriaceae RepID=B7GRV7_BIFLI Length = 284 Score = 267 bits (682), Expect = 4e-70, Method: Composition-based stats. Identities = 87/272 (31%), Positives = 137/272 (50%), Gaps = 4/272 (1%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANS-GERDRTHSIIKGIKDRT 81 S E FPP+ + T+++++D L L P F+SVTYG + +R T I I Sbjct: 4 PMFSLEVFPPKRNAPVDTIYDTLDGLEGLNPDFISVTYGHGTHSDRTATARIAHTISKEY 63 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG--KPEMYASDLVTLL 139 G+ A HLT + + ++ + G+ ++ALRGD G +ASDLV+ + Sbjct: 64 GIPAVAHLTALYSDKAKIDEALDMFEQAGVSAVLALRGDYIDGERLVGDFNHASDLVSYI 123 Query: 140 KEV-ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRC 198 + + D + A YPE H ++ S D+ NLK KVDAG R I+Q F+D E + RF D+ Sbjct: 124 RSMKPDLTVFGACYPEGHYQSGSLDQDIENLKIKVDAGVTRLISQLFYDNEDFYRFLDKA 183 Query: 199 VSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAM 258 +AGI V I GI+PV K ++ A+ RIP + + + +DD ++ + G A Sbjct: 184 RAAGITVPIEAGIMPVRGAKSVRRMAERNASRIPDKLDALLNRWEDDIQSLRTAGILYAS 243 Query: 259 DMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + + L GV H Y++N + I + Sbjct: 244 EQIADLVAHGVDGVHLYSMNHPATTRRIWRNV 275 >UniRef50_Q4Q0B9 Methylenetetrahydrofolate reductase n=3 Tax=Leishmania RepID=Q4Q0B9_LEIMA Length = 309 Score = 265 bits (679), Expect = 1e-69, Method: Composition-based stats. Identities = 84/295 (28%), Positives = 139/295 (47%), Gaps = 20/295 (6%) Query: 17 AEVQGQINVSFEFFPPRTSEMEQTLWNS-IDRLSSLKPKFVSVTYGANSGERDRTHSIIK 75 AE + N S+E +PPR+ + E+ + + P F+ +T+GA T + K Sbjct: 11 AEDASKWNTSYELYPPRSEKAEEDMMKVLVPNFMHQSPVFLDLTWGAGGRTSGTTMRLCK 70 Query: 76 GIKDRTGLEAA-PHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG---KPEMY 131 ++ H+TC + ++ +GIR+I+ALRGD P G P+ + Sbjct: 71 DLQHAHPDTPINMHITCTNTPKGLIKETLEFAKTHGIRNILALRGDPPSGEEFQVDPDGF 130 Query: 132 AS--DLVTLLKEVAD--FDISVAAYPEVHPEA---------KSAQADLLNLKRKVDAGAN 178 A DLV +++ F +SVA YPE HP + Q +L LK KVDAGA+ Sbjct: 131 ACARDLVRYIRDTYGDYFCVSVAGYPEGHPSRIAENGTISHEDHQKELEYLKEKVDAGAS 190 Query: 179 RAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQM 238 ITQ F+D Y++F RC GI V I+ G+LP++ + + + +P+ + + Sbjct: 191 FIITQLFYDASLYVKFVKRCREVGITVPILAGLLPITTYAGFVRMVSLCKTSVPSDVKKR 250 Query: 239 FDGLDDDAETRKLVGANIAMDMVKILSREGVK--DFHFYTLNRAEMSYAICHTLG 291 + L ++ + K G + M++ + G+ HFYTLN + + I L Sbjct: 251 VEELKENPDGLKEYGVEQCVQMIECIRASGLDYHHLHFYTLNNSAQIFKILKRLN 305 >UniRef50_Q058D8 Methylenetetrahydrofolate reductase n=1 Tax=Buchnera aphidicola str. Cc (Cinara cedri) RepID=Q058D8_BUCCC Length = 293 Score = 264 bits (674), Expect = 4e-69, Method: Composition-based stats. Identities = 116/293 (39%), Positives = 171/293 (58%) Query: 1 MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY 60 M + + + ++ +I +SFE FPP +++ L+ SI L+ P+F SVT Sbjct: 1 MVTEIKNIKKLYTDKIYNLKNKIKISFEVFPPGDIFLQKKLFKSIKILNQFNPEFFSVTN 60 Query: 61 GANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD 120 D+T I+K I++ H T I ++ IA YWN+GI++I+ALRGD Sbjct: 61 STKINSFDQTFFIVKKIRELIHCTVFAHFTTIGCNELKIEKIAHRYWNHGIKNIIALRGD 120 Query: 121 LPPGSGKPEMYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRA 180 LP + +YA DL+ LL + F I VAAYPE HPE+K+ Q DL NL+ K+D G +A Sbjct: 121 LPVLYSRKIIYAVDLIKLLNSINKFKIFVAAYPEGHPESKNIQEDLNNLRNKLDLGVKQA 180 Query: 181 ITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFD 240 ITQFFF+++ +L+FRD C S G++V +IPGILP+ NF+Q KKF++MTNV +P W+ F Sbjct: 181 ITQFFFNIDKFLKFRDTCFSLGLNVNLIPGILPILNFEQLKKFSNMTNVEVPKWILNTFH 240 Query: 241 GLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 +D + I +D++ L EG+ FH YTLN+ + IC LG+ Sbjct: 241 RHKNDEKKCISCSVYIIIDLIIKLYNEGITHFHLYTLNQPHLISLICQRLGLV 293 >UniRef50_O74927 Methylenetetrahydrofolate reductase 2 n=2 Tax=Schizosaccharomyces RepID=MTHR2_SCHPO Length = 641 Score = 263 bits (673), Expect = 5e-69, Method: Composition-based stats. Identities = 88/296 (29%), Positives = 138/296 (46%), Gaps = 22/296 (7%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSS-LKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G SFE+FPP+T+ + L + I R+S + P F SVT+G + + + K ++ Sbjct: 13 GNAFYSFEYFPPKTTVGLENLSSRITRMSRNMMPLFSSVTWGTAGSTAEVSIYLAKMLEQ 72 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM------YAS 133 + A HLTC + + GIR+I+ALRGD P S E +A Sbjct: 73 HHKIPACLHLTCTNVDKAIIDKALETAKEYGIRNILALRGDPPLNSDHWEGKVSEFEHAV 132 Query: 134 DLVTLLKEVAD--FDISVAAYPEVHPE------AKSAQADLLNLKRKVDAGANRAITQFF 185 DLV ++E F I VAAYPE H + +K D+ L KV+AGA+ ITQ F Sbjct: 133 DLVRYIREKYGDYFCIGVAAYPEGHVDSNVPELSKDPLRDIPFLIEKVEAGADFIITQIF 192 Query: 186 FDVESYLRFRDRCVSAGIDV----EIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDG 241 ++ E++++F + + + IIP I+P+ ++ K+ + +P+ + Q + Sbjct: 193 YEPEAFIKFENFVRNHSSNALRNIPIIPAIMPIQSYGSLKRMTRLCGCSVPSSLMQRLNA 252 Query: 242 LDDDAETRKLVGANIAMDMVKILSRE---GVKDFHFYTLNRAEMSYAICHTLGVRP 294 D E K +G +DM+K + V FHF TLN I G+ Sbjct: 253 AKPDDEAIKNIGVEHIVDMIKKIMDNVQGRVHGFHFCTLNLERSVALILKNSGLLT 308 >UniRef50_C6BZ56 Methylenetetrahydrofolate reductase n=1 Tax=Desulfovibrio salexigens DSM 2638 RepID=C6BZ56_DESAD Length = 293 Score = 263 bits (672), Expect = 5e-69, Method: Composition-based stats. Identities = 83/282 (29%), Positives = 121/282 (42%), Gaps = 8/282 (2%) Query: 17 AEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKG 76 GQ SFEFFPP+ RL++LKP F SVTYGA D + I Sbjct: 7 INEAGQF-FSFEFFPPKDKSTWPVFMERAARLAALKPLFASVTYGAGGTSHDNSLEICSL 65 Query: 77 IKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK----PEMYA 132 +K G++ HLTC+ A+ + G+ I+AL GD + +A Sbjct: 66 LKKDMGIDILAHLTCVGASEQSIDEFVSRLCETGVSDILALGGDGVKDANGEGQSRFFHA 125 Query: 133 SDLVTLL-KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESY 191 SDLV + + ++ I+VA YP HPE+ S D+ K+ GA+ +TQ FFD Y Sbjct: 126 SDLVEYVDDKFSEVGIAVAGYPGGHPESPSIAKDIEIHNSKLSKGADFTMTQLFFDNRLY 185 Query: 192 LRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGL--DDDAETR 249 + DR G +IPG+LP+ + ++ + IP + + E Sbjct: 186 FDYVDRLAELGSTAPVIPGVLPIQSLSSLRRIMSLCGAGIPGDLYCGVEKAFEKGGDEAV 245 Query: 250 KLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 G + A + L G H Y+LNRA M + L Sbjct: 246 MEFGFDFARKQISDLLDRGAPGVHIYSLNRAAMCERLITDLK 287 >UniRef50_C8NQ26 Methylenetetrahydrofolate reductase n=20 Tax=Corynebacterineae RepID=C8NQ26_COREF Length = 326 Score = 262 bits (670), Expect = 9e-69, Method: Composition-based stats. Identities = 101/310 (32%), Positives = 152/310 (49%), Gaps = 19/310 (6%) Query: 4 FHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN 63 +SQ V G++ S EF PPR E L+ + + L FVSVTYGA Sbjct: 7 SASSQWSISEVLKRPVPGRVPFSVEFMPPRDDAAENRLYRAAEVFHDLGASFVSVTYGAG 66 Query: 64 SGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP 123 R+RT + + + + L HLT +D T EL+ I R Y G+ +++ALRGD P Sbjct: 67 GSTRERTARVARRLSRQ-PLTTLVHLTLVDHTIAELQEILRGYAELGLTNLLALRGDPPG 125 Query: 124 G-------SGKPEMYASDLVTLLK---EVADFDISVAAYPEVHPEAKSAQADLLNLKRKV 173 S YA +L+ ++K E + FDI +A++PE H A S + D K+ Sbjct: 126 DPLGEWATSEGGMSYALELIEMIKNSPEFSHFDIGIASFPEGHYRAGSLENDTRYTLAKL 185 Query: 174 DAGANRAITQFFFDVESYLRFRDRCVSAGI---DVEIIPGILPVSNFKQAKKFADMTNVR 230 AGA +ITQ FFDVE +LR RDR V+A IIPG++P+++ + ++ +++ Sbjct: 186 RAGAEYSITQMFFDVEDFLRLRDRLVAADPIHGAKPIIPGLMPITSLRSVRRQVELSGST 245 Query: 231 IPAWMAQMFDGLDDDAE-----TRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYA 285 +P + + + E + VG +M + L EGV D HF TLN + Sbjct: 246 LPRALEEKLLRAANGDEEANRNEIRKVGIETTSEMAERLIAEGVPDLHFMTLNFTRATQE 305 Query: 286 ICHTLGVRPG 295 + H LG+ P Sbjct: 306 VLHNLGMAPA 315 >UniRef50_C9L8P5 Methylenetetrahydrofolate reductase n=1 Tax=Blautia hansenii DSM 20583 RepID=C9L8P5_RUMHA Length = 311 Score = 261 bits (668), Expect = 2e-68, Method: Composition-based stats. Identities = 84/310 (27%), Positives = 144/310 (46%), Gaps = 23/310 (7%) Query: 9 RDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERD 68 R L + ++ ++ +SFE FPP+T + + L +I+ L KP+++S TYGA Sbjct: 3 RYKLMKLSDAMREKMLLSFELFPPKTDKGMENLPGTIEHLCKYKPEYISCTYGAGGTNVG 62 Query: 69 RTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP---PGS 125 + + K IK G H TCI T + ++ ++Y +NG+ H++ALRGDLP G+ Sbjct: 63 KNMDVCKMIK-DAGTIPVTHFTCIGNTAEGIKDQLQNYLDNGVDHMLALRGDLPFGWTGT 121 Query: 126 GKPEMYASDLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQ 183 G YA+DLV +++ +I+VA PE H +S +AD+ LK+K D GA+ +TQ Sbjct: 122 GGDFAYATDLVAYVRKEFGDKIEIAVAGSPEGHISCRSLEADIAVLKQKQDNGADYIMTQ 181 Query: 184 FFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNVRIPAWMAQMFDG- 241 +D+E + + D AGI + + GI+P+ + A +P + ++ Sbjct: 182 LCWDMEQFKYWLDAIRCAGITMPVDVGIMPILDQAATINMALSRNACVMPRELCEIISKN 241 Query: 242 ---------------LDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAI 286 ++ K G + + G+ H Y LN+ + I Sbjct: 242 WIFPNPFVQDPFDADVEGKKARFKEAGIEYTIRQIDEYRACGIDGIHLYALNKWKDVSEI 301 Query: 287 CHTLGVRPGL 296 G+R + Sbjct: 302 IDRSGLRTLV 311 >UniRef50_B9Z0I7 Methylenetetrahydrofolate reductase n=1 Tax=Lutiella nitroferrum 2002 RepID=B9Z0I7_9NEIS Length = 287 Score = 261 bits (668), Expect = 2e-68, Method: Composition-based stats. Identities = 102/272 (37%), Positives = 158/272 (58%), Gaps = 5/272 (1%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 S E +PP + + + L ++ RL++L P++ SVTYGA R+RT ++ + G Sbjct: 5 FSLELYPPTSPQSARQLERALPRLAALGPEYFSVTYGAGGCTRERTLDLVGQLH-EAGHT 63 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG--KPEMYASDLVTLLKEV 142 APHL+ + A E+ + Y G+R + ALRGD P G G YASDLV ++E Sbjct: 64 VAPHLSGVGAERAEVAELCAHYRRLGVRRLFALRGDTPSGMGSRGDFAYASDLVRFIREH 123 Query: 143 --ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVS 200 DF I VAAYPEVHP+AKS ADL L+ K +AGAN A+TQ+FF+ +++L RD C + Sbjct: 124 SGDDFRIEVAAYPEVHPQAKSPAADLAALRVKQEAGANAAVTQYFFNTDAFLYLRDSCHA 183 Query: 201 AGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDM 260 AGI + ++PG+LP++ F+ + A+ + +P W+ + + L DD + G ++ Sbjct: 184 AGITLPLVPGVLPLTRFRSTAQRAEARGIEMPRWIYRKMESLADDTAAVRAFGLDVTARQ 243 Query: 261 VKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 + L EGV HF++LN+ + A+ LG+ Sbjct: 244 CERLIAEGVPALHFFSLNQIDAIEALHARLGL 275 >UniRef50_B7GB47 Methylenetetrahydrofolate reductase (Fragment) n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B7GB47_PHATR Length = 376 Score = 260 bits (664), Expect = 5e-68, Method: Composition-based stats. Identities = 95/340 (27%), Positives = 144/340 (42%), Gaps = 70/340 (20%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSS-LKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G+ VS E+FPPRT+E Q L + R+ L+P F +T+GA + + + + Sbjct: 38 GKPFVSLEYFPPRTAEGVQNLHARMHRMRDTLQPAFTDMTWGAGGSTAELSLQLALYAHN 97 Query: 80 RTGLEAAPHLTCIDAT---------------------------PDELRTIARDYWNNGIR 112 TG A H+TC + + LR + + GIR Sbjct: 98 -TGHVANLHMTCTNLDSGKSSTSTSSSSEHNGNASDDVASADPRETLRRALQQAHDGGIR 156 Query: 113 HIVALRGDLPPGSGKP------EMYASDLVTLLKEVA----DFDISVAAYPEVHPEA--- 159 ++VALRGD P G A DLV ++ + DF ++VA YPE HP A Sbjct: 157 NLVALRGDPPAGQETWTATEGGFTCALDLVEFIRSLPDIGADFHLAVAGYPEGHPNAISE 216 Query: 160 ---------------------------KSAQADLLNLKRKVDAGANRAITQFFFDVESYL 192 ++ LK+KVDAG + +TQ FFD +L Sbjct: 217 IADPTTLTAAEAARASVTDGKTYCCLDADYHKEMEYLKKKVDAGGDMIMTQMFFDAAVFL 276 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV 252 +F + C + GI V I+PG++ ++ + K A R+P + + + DDA K Sbjct: 277 QFVEDCRAWGITVPIVPGLMCINAYAGFVKMAKFCKTRVPETLRARMEAIKDDAAAVKAF 336 Query: 253 GANIAMDMVKILSREG-VKDFHFYTLNRAEMSYAICHTLG 291 G ++M + L G V HFYTLN ++ Y + LG Sbjct: 337 GVEFGVEMCRTLLASGHVSVLHFYTLNLEKVVYGVLDALG 376 >UniRef50_D1U6W4 Methylenetetrahydrofolate reductase n=1 Tax=Desulfovibrio aespoeensis Aspo-2 RepID=D1U6W4_9DELT Length = 290 Score = 259 bits (663), Expect = 6e-68, Method: Composition-based stats. Identities = 86/287 (29%), Positives = 130/287 (45%), Gaps = 6/287 (2%) Query: 14 QSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSI 73 L + VS E PPR ++ L +KP F +VT GA T Sbjct: 4 PDLIGSLSRPFVSIELLPPRREAELAGFGQAVQALKGMKPLFAAVTCGAGGRGAVGTLET 63 Query: 74 IKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG---KPEM 130 + + + G PHLTC+ P L GIR+++A+RGD P G K Sbjct: 64 ARDLAEDHGFTVMPHLTCVHVPPAALPGQLDALRTCGIRNVLAVRGDFPAGMEPVSKGFR 123 Query: 131 YASDLVTLLKEV-ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVE 189 +ASDLV ++++ D + VAAYP+ HP+++S D+ L+ K+D GA+ A+TQ FFD Sbjct: 124 HASDLVARVRQLAPDMAVGVAAYPDGHPDSRSILEDIGFLRFKLDQGASFAVTQLFFDNR 183 Query: 190 SYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDG--LDDDAE 247 Y DR + G IIP ILP+ + Q K+ ++ + +P + + D Sbjct: 184 RYFDMVDRLAAMGCTKPIIPSILPIRSLGQIKRVMELCDAPVPGTLLADIEAAHAKDGDA 243 Query: 248 TRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRP 294 + G A + L +G H Y NRA+M + G+ P Sbjct: 244 GVRRYGVAQAASQLSELLEQGAPGVHLYPFNRADMCLEVVQRAGLLP 290 >UniRef50_B2A780 Methylenetetrahydrofolate reductase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A780_NATTJ Length = 305 Score = 257 bits (656), Expect = 5e-67, Method: Composition-based stats. Identities = 83/284 (29%), Positives = 142/284 (50%), Gaps = 13/284 (4%) Query: 19 VQGQINVSFEFFPPR-----TSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSI 73 VSFE FPP+ + E +L +ID L+ LKP F+SVTYGA D + I Sbjct: 9 QSNGPVVSFEIFPPKRKKNQSKEDFDSLLKTIDNLARLKPDFISVTYGAGGTNSDGSLEI 68 Query: 74 IKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG------K 127 + +K++ G+ + PH T I +E+ + +N G +I+ALRGDLP + Sbjct: 69 SEYVKNK-GITSLPHFTSIGYPVEEINSYLGTIYNKGFENILALRGDLPKSPSKADLVWR 127 Query: 128 PEMYASDLVTLL-KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFF 186 ++A+DL+ ++ ++ +F I AAYPE H E+ A D+ +K K G +TQ FF Sbjct: 128 DFLHATDLIKVISRDFPNFCIGGAAYPEGHQESSYAGQDIEIMKIKEKMGVKFFLTQLFF 187 Query: 187 DVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDA 246 + +++ +F + + G++ + G++P+ + K K +++ V++P + + DD Sbjct: 188 NNDNFFKFMENVRNNGVESPVSAGVMPLISPKYVDKIIELSGVKLPKELENALENYRDDE 247 Query: 247 ETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + + + V L GV H YT+NR E I + Sbjct: 248 VEFRKRSLDYCVRQVNDLFERGVDGVHLYTMNRHEAVEEILDQV 291 >UniRef50_C2EUU9 Methylenetetrahydrofolate reductase n=2 Tax=Lactobacillus RepID=C2EUU9_9LACO Length = 281 Score = 256 bits (655), Expect = 6e-67, Method: Composition-based stats. Identities = 84/272 (30%), Positives = 133/272 (48%), Gaps = 4/272 (1%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG-ERDRTHSIIKGIKDRTG 82 +S+E FPP ++ L + L L P F+SVT +N+ T + +++ Sbjct: 3 TLSYEVFPPNSTVGINHLNQVLTSLRDLSPDFISVTCNSNTKQLAHETVRVADYVENDCQ 62 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK--PEMYASDLVTLLK 140 + A HL + +++ I + ++ LRGD P K +ASDL+ +K Sbjct: 63 VPAMAHLPAWYLSREDVDRILEQLRVCHVDRVLVLRGDERPKLEKKTDFAHASDLIAYIK 122 Query: 141 E-VADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199 + DF I+ A YPE HPE+ S ++ +LK KV++G ++ ITQ F D SY RFR+ C Sbjct: 123 QNYPDFQITGACYPEKHPESLSMVDEIQHLKLKVESGCDQIITQLFLDNHSYYRFRELCA 182 Query: 200 SAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMD 259 GIDV II GI+PV N +QA + + V +P + D + K G A+D Sbjct: 183 IGGIDVPIIAGIMPVVNERQANRILRTSAVTVPEKFKDILAKYHDHPQALKQAGITYAID 242 Query: 260 MVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 + L V H YT+N ++ + + +G Sbjct: 243 QIVDLVTNDVSGIHLYTMNHSDTARQVKQNIG 274 >UniRef50_C0QAY2 Methylenetetrahydrofolate reductase n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QAY2_DESAH Length = 293 Score = 256 bits (654), Expect = 8e-67, Method: Composition-based stats. Identities = 88/283 (31%), Positives = 143/283 (50%), Gaps = 6/283 (2%) Query: 15 SLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSII 74 +L + Q +VSFEFFPPR + E + + +D LS+L P ++S+T+GA + + + Sbjct: 5 NLYKNQSDPSVSFEFFPPRDDKAESSFYGVVDALSALNPAYMSMTFGAGGSTSEGSFQAV 64 Query: 75 KGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG-----KPE 129 K + L ++ P E+ + Y G+ I +RGD P G + Sbjct: 65 KRMMIEKNLPMVAYIAGYGLGPHEITEVLDRYKALGVETIFVIRGDKPRTDGFTPHPESF 124 Query: 130 MYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVE 189 +ASDL+ + + DFD+ A YPE H +A+S + D+ L+ K D GA + Q+F+D + Sbjct: 125 AHASDLIRFISDRYDFDLGCAGYPEGHVQAESLEKDVEYLRLKQDNGAQYVVAQYFYDND 184 Query: 190 SYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDA-ET 248 S+ R+ D C +GI + IIPGI+P+ K + + +P + + D L +D E Sbjct: 185 SFYRYVDLCRKSGITIPIIPGIMPIYTVKLTRMLCKLCGSTLPTGLREKLDSLTNDKSEA 244 Query: 249 RKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 +G N A D + L +GV HFYT++R+ I L Sbjct: 245 VADLGVNFAFDQCRDLVLKGVDGLHFYTMDRSGSVLKIVQRLK 287 >UniRef50_A0JXH6 Methylenetetrahydrofolate reductase n=6 Tax=Micrococcineae RepID=A0JXH6_ARTS2 Length = 323 Score = 255 bits (651), Expect = 1e-66, Method: Composition-based stats. Identities = 96/287 (33%), Positives = 142/287 (49%), Gaps = 16/287 (5%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 +S+E FPPR+ ++LW +I L + P +VSVTYGA+ RD +I + T L Sbjct: 20 ALSYELFPPRSPAAAESLWTTIGELEATDPDYVSVTYGASGSNRDTAVELINRLLLETTL 79 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP----EMYASDLVTLL 139 HLTC+ TP+EL I + + G+R I+ALRGD P P YA DL+ L+ Sbjct: 80 RPLAHLTCVGNTPEELSEIIGELLDVGVRGILALRGDRPKDGAAPVSGSLRYAQDLIELI 139 Query: 140 KEVA----------DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVE 189 + V + VAAYP HPE+ + D+ L K +GA+ AITQ FF E Sbjct: 140 RRVEQRRSALLCAGKVAVGVAAYPTRHPESPTEAHDVEVLLAKQRSGADFAITQVFFHTE 199 Query: 190 SYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETR 249 Y R AG+ + IIPG++P+++ ++ + A++T V + D DAE R Sbjct: 200 QYADLITRARRAGVTIPIIPGVMPLTSVRRLNRLAELTGVEPAPELMARLAAADTDAE-R 258 Query: 250 KLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV-RPG 295 +L+G +D+ G H YT N + + L + RP Sbjct: 259 RLIGVRATVDLANAALDAGAPGIHLYTFNEHACALEVLDKLALPRPA 305 >UniRef50_A8QAM7 Methylenetetrahydrofolate reductase n=1 Tax=Malassezia globosa CBS 7966 RepID=A8QAM7_MALGO Length = 589 Score = 255 bits (651), Expect = 2e-66, Method: Composition-based stats. Identities = 92/320 (28%), Positives = 149/320 (46%), Gaps = 31/320 (9%) Query: 4 FHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSS-LKPKFVSVTYGA 62 A + LN S + S EFFPPRT+ L + R+S L+P +V VT+G Sbjct: 8 LSARIDEKLNDSTQDA---YVWSLEFFPPRTALGLANLCARVARMSEALQPGWVHVTWGT 64 Query: 63 NSGERDRTHSIIKGIK----------------DRTGLEAAPHLTCIDATPDELRTIARDY 106 RD + + ++ + + HLTC + L + Sbjct: 65 GGSTRDASMELAARVQKGVYDPLEDYTNVKERRKGACDVCLHLTCTNVERAYLDATLDEA 124 Query: 107 WNNGIRHIVALRGDLPPGSGKPEM------YASDLVTLLKEVAD--FDISVAAYPEVHPE 158 GIR+I+ALRGD P A+DLV ++E F I VA YPE + Sbjct: 125 RQIGIRNILALRGDPPRSDEYWVATDQRLQNATDLVRYIRERHGDYFCIGVAGYPEGLKQ 184 Query: 159 AKS--AQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSN 216 + D+ LK K +AGA+ +TQ F+DV++ +R+ C +AGI + IIPGI+P+ N Sbjct: 185 GIDCDMRHDIKVLKAKQEAGAHFIVTQLFYDVDALVRWTKECRAAGITIPIIPGIMPIQN 244 Query: 217 FKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSRE-GVKDFHFY 275 + ++ A++ V P + + + + D K G ++++DM+K + + G++ FH Y Sbjct: 245 YTMFRRMANLCGVHTPEDVLEQLEPIKMDDAKVKEHGIHLSIDMIKSIREQTGIRAFHLY 304 Query: 276 TLNRAEMSYAICHTLGVRPG 295 TLN + + + L P Sbjct: 305 TLNLEKSATCVIKVLADVPD 324 >UniRef50_D1PME0 Methylenetetrahydrofolate reductase n=1 Tax=Subdoligranulum variabile DSM 15176 RepID=D1PME0_9FIRM Length = 287 Score = 252 bits (643), Expect = 2e-65, Method: Composition-based stats. Identities = 73/275 (26%), Positives = 124/275 (45%), Gaps = 4/275 (1%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDR-THSIIKGIK 78 + S E FPP+ + + L ++ + L+P F+SVT+GA T + I+ Sbjct: 9 AKRCVFSIECFPPKQTTQMEKLRGTLFAMKDLQPDFISVTFGAGGSAGGVSTVEVADLIQ 68 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD--LPPGSGKPEMYASDLV 136 + G+ A HL C+ I + G+ ++ALRGD +A DL Sbjct: 69 NELGIPALAHLICMGNDKTSAAKILDELEQVGVHDVLALRGDRTPNRPESPDFAHACDLT 128 Query: 137 TLLKEV-ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFR 195 +K F + A YPE HPEA++ + D+ NL K AGA +TQ FFD + RF Sbjct: 129 AFIKSYKPGFSVHGACYPEGHPEAENLRQDVENLCTKQAAGAEHLVTQLFFDNMHFYRFL 188 Query: 196 DRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGAN 255 + AGI + + G++P+ Q ++ +++ +P+ +M DD G + Sbjct: 189 NLARRAGITLPVSAGVMPIVKRSQIERTVALSSASLPSDFTRMISRWQDDPAALYEAGID 248 Query: 256 IAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 A+ ++ L G H Y +N A ++ + + Sbjct: 249 YAVRQLRDLIEGGADGVHLYAMNDAAVAKKVYDGI 283 >UniRef50_C4R2Q6 Methylenetetrahydrofolate reductase n=6 Tax=Saccharomycetaceae RepID=C4R2Q6_PICPG Length = 603 Score = 250 bits (639), Expect = 4e-65, Method: Composition-based stats. Identities = 82/276 (29%), Positives = 135/276 (48%), Gaps = 15/276 (5%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 SFEFF P+T++ Q L++ +DR+ +L P+F+ +T+ A + T +I + G Sbjct: 18 PTFSFEFFTPKTAQGVQNLYDRMDRMYNLSPQFIDITWNAGGRSSNLTCEMINTAQTVLG 77 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP---EMYASDLVTLL 139 LE HLTC + T + + + +++G ++I+ALRGD P + YA DL+ + Sbjct: 78 LETCMHLTCTNMTLEVIDEALKSAYDSGCQNILALRGDPPLDGSESTGCFRYAKDLIKHI 137 Query: 140 KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199 KE HP+ + LK K DAG + ITQ F+DVE ++ + + Sbjct: 138 KEKY-----------GHPDEPDVDRLIEILKEKQDAGGDFMITQMFYDVEQFITWCKKVR 186 Query: 200 SAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMD 259 GI + IIPGI+P+S + + A + +P+W + D DD + +G + D Sbjct: 187 DYGITIPIIPGIMPISTYASFSRRAKWCQINVPSWFQKQLDASKDDDSEVRCLGTQLVAD 246 Query: 260 MVKILSREG-VKDFHFYTLNRAEMSYAICHTLGVRP 294 M L G V HFYT+N + + + L + Sbjct: 247 MCLKLVESGYVNHLHFYTMNLEKSTIMVLEKLQLID 282 >UniRef50_Q03V90 Methylenetetrahydrofolate reductase n=2 Tax=Leuconostoc mesenteroides RepID=Q03V90_LEUMM Length = 297 Score = 250 bits (638), Expect = 5e-65, Method: Composition-based stats. Identities = 76/286 (26%), Positives = 129/286 (45%), Gaps = 5/286 (1%) Query: 11 ALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRL--SSLKPKFVSVTYGANS-GER 67 + + + +SFE FPP+T + L+ ++ + ++SVTYGA Sbjct: 2 TRITDIYKKKSAPVLSFEIFPPKTEDGLHALYKTLQEVNPKETGVDYISVTYGAGGGSNH 61 Query: 68 DRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS-- 125 RT I + I+ G+ A +LT I+ TP L+ G+ +I ALRGD P Sbjct: 62 KRTKEIAEYIERNCGITALHNLTGINQTPSSLKGNLEKISVAGVENIFALRGDTPTKDYV 121 Query: 126 GKPEMYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFF 185 + +A DL+ +K+ FDI A YPE H + + + +K KV +G I+Q F Sbjct: 122 NEYYPFAKDLIKEIKKDGRFDIGAAIYPEGHVDNPTTGISVTGVKEKVISGTEFLISQLF 181 Query: 186 FDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDD 245 FD + ++ I V + GILP+ + Q ++ M +PA +A++ +D Sbjct: 182 FDNGVFYNMQEALKENYIKVPVSAGILPIISRAQVERITYMIGSSLPARLAKIVHKYEDQ 241 Query: 246 AETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 E + G A++ + L GV H Y +N+ + + + Sbjct: 242 PEALQQAGIEYALEQIHDLLDHGVDGIHLYAMNQPNVLKIMLPEIN 287 >UniRef50_A9BEZ6 Methylenetetrahydrofolate reductase n=2 Tax=Thermotogaceae RepID=A9BEZ6_PETMO Length = 315 Score = 249 bits (637), Expect = 8e-65, Method: Composition-based stats. Identities = 85/309 (27%), Positives = 132/309 (42%), Gaps = 33/309 (10%) Query: 15 SLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN----------- 63 L + + +SFE PP E +++N +D L PK+++VT AN Sbjct: 5 DLIKQSNKPVLSFEIIPPNVGESIDSIFNVVDNLIEFSPKYINVTKHANEIDYVEENGKI 64 Query: 64 ----SGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRG 119 +R T + IK R +E PHL C +L I D I +I +RG Sbjct: 65 MKIIQKKRPGTVGVSASIKHRYNIEVVPHLICTGFNKYQLEDILIDLNYLRIENIFVVRG 124 Query: 120 DLPP---GSGKPEMYASDLVTLLKEVA--------------DFDISVAAYPEVHPEAKSA 162 D +AS LV + + +F + VA YPE H E+ + Sbjct: 125 DKKRYTWKETDEYEHASQLVEQIANMNRGIYTFPTKEHNSTNFCVGVAGYPEKHFESPNF 184 Query: 163 QADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKK 222 + DL LK KVD GA ITQ FFD+E Y F ++ GI+V IIPGI P+ + K Sbjct: 185 EKDLDYLKLKVDMGATFIITQMFFDIEYYKNFVNKVRDLGIEVPIIPGIKPLGSKKTLYN 244 Query: 223 FADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEM 282 +V IP + + F+ + ++G A+ +++ L GV H +T+ + ++ Sbjct: 245 IPKTFHVNIPKSIVEEFENAKSSQDE-YIIGVRHAIKLIEQLLELGVPGVHLFTMGKGKI 303 Query: 283 SYAICHTLG 291 + Sbjct: 304 VKDVLSAFK 312 >UniRef50_D1BTF0 Methylenetetrahydrofolate reductase n=2 Tax=Actinomycetales RepID=D1BTF0_XYLCX Length = 323 Score = 249 bits (636), Expect = 1e-64, Method: Composition-based stats. Identities = 83/296 (28%), Positives = 144/296 (48%), Gaps = 25/296 (8%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + VSFE PPR + W + RL +++P FVSVTYGA G+R ++ + T Sbjct: 14 RPTVSFELMPPRRPDAAPNFWETARRLVAVQPDFVSVTYGAGGGDRATARQVVATLLAGT 73 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE------MYASDL 135 + HLTC+ A+ +++ + D+ G+R +ALRGD P A +L Sbjct: 74 PVLPIAHLTCVGASREDVSEVIDDFLEAGVRAFLALRGDPPKDQPDWRPPVDGVHSADEL 133 Query: 136 VTLLKEV-----------------ADFDISVAAYPEVHPEAKSAQ-ADLLNLKRKVDAGA 177 V LL+EV I+VA +P+ +P A + + ++ L K AGA Sbjct: 134 VRLLREVESARAAADPSSALRGAAHPLSIAVATFPDGNPAAGTTRAQEVQRLLAKQSAGA 193 Query: 178 NRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQ 237 + AITQ F++ +SY++F +AG+ + I+ G+LP + ++ ++ ++T V P + Sbjct: 194 SFAITQLFYEADSYIQFVAEARAAGVTIPILAGLLPTTEPRRLRRVEELTGVVAPPDLLD 253 Query: 238 MFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 D L DAE + G ++++ + + G H YT N+ + + +G+ Sbjct: 254 ALDAL-PDAEAQHEYGIARSVELARAVLDAGAPGLHVYTFNKHRPALDLLAGIGLL 308 >UniRef50_A7TTE9 Methylenetetrahydrofolate reductase n=2 Tax=Saccharomycetaceae RepID=A7TTE9_VANPO Length = 612 Score = 244 bits (624), Expect = 2e-63, Method: Composition-based stats. Identities = 73/255 (28%), Positives = 107/255 (41%), Gaps = 24/255 (9%) Query: 64 SGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP 123 R + GLE HLTC + + + +G +I+ALRGD P Sbjct: 35 QTAARRPTRSCFTAQSVLGLETCMHLTCTNMSLAAIDAALEQAHASGCHNILALRGDPPR 94 Query: 124 GS---------------------GKPEMYASDLVTLLKEVAD--FDISVAAYPEVHPEAK 160 G +A+ LV ++ F I VA YPE E Sbjct: 95 GQPSTASSSESGSSGGGNGSSDGDCNFKFAAQLVRYIRSKYGNHFAIGVAGYPEGDGEQA 154 Query: 161 SAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQA 220 + L +LK KV+ GA+ ITQ F+DV+++LR+ G+ V IIPGI+P+S + Sbjct: 155 DQRLLLQHLKEKVECGADFIITQMFYDVDNFLRWVHGLREVGVTVPIIPGIMPISTYAAF 214 Query: 221 KKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREG-VKDFHFYTLNR 279 + VR+P Q + DD E + +G + +DM + L G V H YT+N Sbjct: 215 LRRCSWCGVRVPDNFLQRLAPVSDDDELVREIGTQLVVDMCRRLLESGVVSHLHLYTMNL 274 Query: 280 AEMSYAICHTLGVRP 294 I LG+ P Sbjct: 275 ERPPLVILERLGLLP 289 >UniRef50_C3PE90 Methylenetetrahydrofolate reductase n=8 Tax=Corynebacterium RepID=C3PE90_CORA7 Length = 307 Score = 244 bits (623), Expect = 3e-63, Method: Composition-based stats. Identities = 81/304 (26%), Positives = 137/304 (45%), Gaps = 13/304 (4%) Query: 3 FFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGA 62 ++ D +++ + + +SFE PPR + + L++ P +++VT Sbjct: 5 LSASAPLDQISEDTPKELKRTALSFEVIPPRHDADAAKIDRLLATLAAYNPDYIAVTSSQ 64 Query: 63 NSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP 122 SG + T + I+ I T + HL C T +EL + G+R ++ALRGDLP Sbjct: 65 RSGWLEGTAAFIEKISRDTAMRPLAHLACTAGTEEELVGWIDTLVDAGVRGLLALRGDLP 124 Query: 123 PGS--GKPEMYASDLVTLLKEVA----------DFDISVAAYPEVHPEAKSAQADLLNLK 170 G +A LV L++ + VA YP H E+ + D+ L Sbjct: 125 EGGMPEGHLPHADSLVRLIRRWESDRVARLAAGRLAVGVACYPNGHAESATPDEDIDVLL 184 Query: 171 RKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVR 230 K GA+ AITQ FFD E Y+RF R AG+ + +IPGI+P+++ + ++ ++ + Sbjct: 185 AKQRLGADFAITQLFFDAEDYVRFAQRARLAGVRIPLIPGIMPMTSRARVERMCQLSGLA 244 Query: 231 IPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 P + E K +G I + K + G H YT N +++ + + + Sbjct: 245 GPTKVLDQLAAATS-PEEEKEIGMQITASLAKSVMNAGADGLHIYTHNNPDITTDLLNRI 303 Query: 291 GVRP 294 GV P Sbjct: 304 GVTP 307 >UniRef50_C7QYL7 Methylenetetrahydrofolate reductase n=2 Tax=Actinomycetales RepID=C7QYL7_JONDD Length = 339 Score = 244 bits (622), Expect = 4e-63, Method: Composition-based stats. Identities = 83/295 (28%), Positives = 137/295 (46%), Gaps = 25/295 (8%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + VSFE PPR WN+ +L P FVSVTYGA G+RD ++++ + T Sbjct: 15 RPTVSFELMPPRNPAAAPKFWNTARKLVEAHPDFVSVTYGAAGGDRDSARTVVETLVQHT 74 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE------MYASDL 135 + HLTC+ AT D + D+ G R +ALRGD P + + +L Sbjct: 75 NVLPIAHLTCVGATRDNVADTIDDFLAAGARTFLALRGDPPKDQPDWAPPTNGVVSSLEL 134 Query: 136 VTLLKE-----------------VADFDISVAAYPEVHPEAK-SAQADLLNLKRKVDAGA 177 + LL++ + I+VA +PE + +A + + + L +K AGA Sbjct: 135 IALLRDVEAQRCQADASEALRGAMKPLTIAVATFPEGNRDAGTTREQEAARLLQKQQAGA 194 Query: 178 NRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQ 237 N AITQ F+ +Y F D S G+ + I+ GILP+++ ++ ++ +T V +P +A Sbjct: 195 NFAITQLFYTASAYTEFVDVARSLGVTIPIVAGILPMTDPQRLRRLEQLTGVPVPLELAA 254 Query: 238 MFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 D + R G ++D+ + G H YT N+ E + + + + Sbjct: 255 QLDAIAS-PHVRHSHGIAASVDLANAVLDSGAPGLHIYTFNKHEPALDLLEGVHL 308 >UniRef50_Q2S0T1 Methylenetetrahydrofolate reductase n=4 Tax=cellular organisms RepID=Q2S0T1_SALRD Length = 319 Score = 243 bits (621), Expect = 5e-63, Method: Composition-based stats. Identities = 76/307 (24%), Positives = 132/307 (42%), Gaps = 38/307 (12%) Query: 18 EVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANS------------- 64 + + + +S+E PP+ + ++ L +P F+ VT + Sbjct: 8 DRESEPLISYEIIPPKRGGSADQILGVVEELMPYEPPFIDVTSHSAEVEYKQKDDGTWTR 67 Query: 65 ---GERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL 121 +R T + I+ R ++ PH+ C T +E + G+ +++A+RGD Sbjct: 68 CVKRKRPGTIGLCAAIEARFDIDTVPHILCKGFTREETEDALIELNYLGVENVLAIRGDD 127 Query: 122 ------PPGSGKPEMYASDLVTLLKEVA--------------DFDISVAAYPEVHPEAKS 161 G+ YA DLV ++++ DF + V YPE H EA + Sbjct: 128 NGYEKSISGNRSRNEYAVDLVRQIQDMNEGTYLEDLMDAEPTDFCVGVGGYPETHFEAPN 187 Query: 162 AQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAK 221 D++ LK +VDAGA+ +TQ FFD E + F D+C GI+V I+PG+ + + + Sbjct: 188 LAWDIMRLKEQVDAGADYIVTQMFFDNEYFFNFVDKCREVGIEVPIVPGLKILKRKRHLR 247 Query: 222 KFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAE 281 + IP +A D D + + +G N A+ + L GV HFY ++ A+ Sbjct: 248 LLPKYFHTEIPEELAAEVDAA--DPDDVERIGVNWAIRQARELMEAGVPGIHFYIMSSAD 305 Query: 282 MSYAICH 288 + Sbjct: 306 TVKKVVE 312 >UniRef50_A6L1E2 Methylenetetrahydrofolate reductase n=45 Tax=Bacteroidetes RepID=A6L1E2_BACV8 Length = 317 Score = 242 bits (619), Expect = 8e-63, Method: Composition-based stats. Identities = 71/313 (22%), Positives = 120/313 (38%), Gaps = 38/313 (12%) Query: 15 SLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYG------------- 61 L + SFE PP + L+ ++D L PK++++T Sbjct: 5 DLIKSTDNTAFSFEILPPLKGTGIEKLYKTVDTLREFDPKYINITTHRSEYVYKELGNGL 64 Query: 62 ---ANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALR 118 R T ++ ++++ + PH+ C + ++ + D GI ++ LR Sbjct: 65 YQRTRQRRRPGTVAVAAALQNKYNITTVPHILCSGFSREDTEYVLLDLQFLGITDLLVLR 124 Query: 119 GDLPPGSGKP------EMYASDLVTLLKEVAD---------------FDISVAAYPEVHP 157 GD +A +L + + F VA YPE H Sbjct: 125 GDKAKHESAFVPENNGYNHAIELEEQINDFNKGVFVDGSPIKVTGTPFSYGVACYPEKHE 184 Query: 158 EAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNF 217 E+ + + D+ LK+K++AGA A+TQ F+D Y F +R GI+V IIPGI P Sbjct: 185 ESPNMEQDIYWLKKKIEAGAEYAVTQMFYDNRKYFEFVERVRKEGINVPIIPGIKPFRKL 244 Query: 218 KQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTL 277 Q + +P +A D E + +G + + L GV HFYT+ Sbjct: 245 SQLNMIPKTFKIDLPQELAGEAMKCQTDEEA-ESLGIEWCIHQCRELIACGVPSIHFYTV 303 Query: 278 NRAEMSYAICHTL 290 + + + Sbjct: 304 SAVNSVKEVAKAI 316 >UniRef50_B5Y6J3 Methylenetetrahydrofolate reductase n=2 Tax=Bacteria RepID=B5Y6J3_COPPD Length = 318 Score = 241 bits (615), Expect = 3e-62, Method: Composition-based stats. Identities = 82/316 (25%), Positives = 131/316 (41%), Gaps = 40/316 (12%) Query: 14 QSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKP-KFVSVTYGANSGE------ 66 + +++ +S E PP + ++ ++D L + P F++VT A Sbjct: 2 KVTDKIKQGRIISIEVLPPNRGHSAEDIFKAVDELITDYPISFINVTRHAAETTYVELED 61 Query: 67 ----------RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVA 116 R T + + R ++ PH+ C EL + D + G++++ A Sbjct: 62 GIIVKVPKVKRPGTVGLTAALMKRYSVDVVPHVLCRGMNKFELEDLLIDLYLIGVQNVFA 121 Query: 117 LRGDLPPGSGK--------PEMYASDLVTLLKEVA--------------DFDISVAAYPE 154 +RG+ G+ YA DLV + + DF I VA YPE Sbjct: 122 IRGEYENAEGESKQENNKDYHTYAVDLVQQIAHMNKGHYLYQKESTMSTDFCIGVAGYPE 181 Query: 155 VHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPV 214 H EA + + D+ +LK KV+AGAN ITQ FD + Y F +R S GI+V IIPGI PV Sbjct: 182 KHFEAPNLEEDMKHLKEKVEAGANYIITQMVFDFDVYKDFVERARSIGINVPIIPGIKPV 241 Query: 215 SNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHF 274 + K V IP + E VG +V+ L G H Sbjct: 242 VSLKSIYSIPRKFFVNIPHAFLEKMQEAKSSKEEF-EVGTAFMASLVEKLLSWGAPGLHL 300 Query: 275 YTLNRAEMSYAICHTL 290 +T+ +++ + A+ + Sbjct: 301 FTMGKSKSAKALLQAV 316 >UniRef50_D0JBB4 Methylenetetrahydrofolate reductase n=31 Tax=Bacteria RepID=D0JBB4_BLASB Length = 320 Score = 240 bits (613), Expect = 4e-62, Method: Composition-based stats. Identities = 91/311 (29%), Positives = 134/311 (43%), Gaps = 41/311 (13%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYG---------ANS------ 64 + SFE PP + +++++D L P F+ VTY N Sbjct: 10 AKKTLFSFEILPPLRGHDIKDIFSTLDPLMEFNPPFIDVTYHREEFIYVEKENGLLQRRK 69 Query: 65 -GERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP 123 R T I I ++ G++A PHL C D GI +++ LRGD Sbjct: 70 ISRRPGTVGICAAIMNKYGVDAVPHLICGGFNKQMTENALIDLNFLGIDNVLVLRGDPLK 129 Query: 124 GSGKP------EMYASDLVTLLKEV------------------ADFDISVAAYPEVHPEA 159 YA +LV +K++ DF I VA YPE H EA Sbjct: 130 SEKDFIAKKDGHKYAVELVEQVKDLNRGKYLDKTFVERKESPLFDFCIGVAGYPEKHLEA 189 Query: 160 KSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQ 219 + ++DL LK+KV++GA+ +TQ FFD + Y F +C S GI V IIPGI P+S+ KQ Sbjct: 190 PNIESDLFFLKKKVESGADYIVTQMFFDNKKYFSFVKKCRSEGISVPIIPGIKPISSKKQ 249 Query: 220 AKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNR 279 + IP + + + D + +G A+ K L GV+ H+YT++R Sbjct: 250 LNSLPSHFYLNIPNELVKEVEKAK-DKKIISHIGIEWAIHQSKELKNFGVEVIHYYTMDR 308 Query: 280 AEMSYAICHTL 290 E Y I + Sbjct: 309 PENIYKIIQAI 319 >UniRef50_A3H552 Methylenetetrahydrofolate reductase (Fragment) n=2 Tax=Vibrio cholerae RepID=A3H552_VIBCH Length = 208 Score = 239 bits (610), Expect = 1e-61, Method: Composition-based stats. Identities = 166/206 (80%), Positives = 186/206 (90%) Query: 89 LTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVADFDIS 148 LTCIDAT DEL IA DYW+NGI++IVALRGD+P G GKPEMYASDLVTLLK DFDIS Sbjct: 1 LTCIDATRDELIQIADDYWHNGIQNIVALRGDIPAGGGKPEMYASDLVTLLKSRHDFDIS 60 Query: 149 VAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEII 208 VAA+PEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV+AGIDVEI+ Sbjct: 61 VAAFPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVAAGIDVEIV 120 Query: 209 PGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREG 268 PGILPVSNFKQA +FA NV++P WM + F+GL+DD TR+LVGA+ A+DMV++L REG Sbjct: 121 PGILPVSNFKQASRFAAQNNVKVPNWMVKQFEGLEDDPVTRQLVGASQAIDMVRVLCREG 180 Query: 269 VKDFHFYTLNRAEMSYAICHTLGVRP 294 VKDFHFYTLNRAEM+YA+CHTLGVRP Sbjct: 181 VKDFHFYTLNRAEMTYALCHTLGVRP 206 >UniRef50_D1BI58 Methylenetetrahydrofolate reductase n=2 Tax=Micrococcineae RepID=D1BI58_SANKS Length = 354 Score = 238 bits (607), Expect = 2e-61, Method: Composition-based stats. Identities = 79/295 (26%), Positives = 142/295 (48%), Gaps = 25/295 (8%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + +SFE PPR W+++D L + +P FVSVTYGA G+R ++++ I + Sbjct: 29 RPTLSFELMPPRNPAAAPKFWSTVDHLVAARPDFVSVTYGAAGGDRTTAQTVVRRILEHA 88 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY------ASDL 135 + HLTC+ A+ D + + ++ G+R +ALRGD P + + + +L Sbjct: 89 PVLPIAHLTCVGASRDNVAEVIDEFLAEGVRSFLALRGDPPRDQPDWQPHPDGVNSSDEL 148 Query: 136 VTLLKEV-----------------ADFDISVAAYPEVHPEAKSAQ-ADLLNLKRKVDAGA 177 V LL+EV I+VA + + + A + + ++ L K AGA Sbjct: 149 VALLREVEAQRCAEDPSSALRSAARPLTIAVATFLDGNAAAGTTRSQEVQRLLEKQQAGA 208 Query: 178 NRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQ 237 + AITQ F+D +SY+ F D AG+ + I+ G+LP+++ + + +T V P + + Sbjct: 209 DFAITQLFYDADSYVGFVDEARRAGVTLPILAGLLPMTDPARLARVETLTGVPAPKALVR 268 Query: 238 MFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 + L D R G ++++ + + G H YT N+ E + + + + Sbjct: 269 DLESLT-DPAARHAHGIRASVELAEAVLAAGAPGLHIYTFNKHEAALDLLEGVHL 322 >UniRef50_C5BVR3 Methylenetetrahydrofolate reductase n=1 Tax=Beutenbergia cavernae DSM 12333 RepID=C5BVR3_BEUC1 Length = 337 Score = 232 bits (593), Expect = 8e-60, Method: Composition-based stats. Identities = 95/309 (30%), Positives = 150/309 (48%), Gaps = 27/309 (8%) Query: 12 LNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTH 71 + S + +SFE +PPRT E+ W +++ L P + SVTYGA+ + Sbjct: 1 MTTSTLYTPARPTISFELYPPRTPAGEERAWETVEALVGADPDYFSVTYGASGSTATASQ 60 Query: 72 SIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP--- 128 S+++ I T + A HLTC+ + + R + + ++G+R +ALRGD P G+ Sbjct: 61 SLVRRILTETDVPAVAHLTCVGLSREHARDVVGGFLDDGVRDFLALRGDPPAGNPDWRPA 120 Query: 129 ---EMYASDLVTLLKEVAD--------------FDISVAAYPEV--HPEA--KSAQADLL 167 A DLV L++++ D I+VAAYP + HP A + DL Sbjct: 121 PGGLARACDLVALIRDLEDERFAGNAHADVANRLSIAVAAYPGMQEHPGAEFRVRDCDLE 180 Query: 168 NLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMT 227 L K GA+ AITQ FFDV +Y D AG+ + ++PG+LP+++ ++ ++ ++ Sbjct: 181 ALVAKQRCGADYAITQVFFDVRAYTALVDAARGAGVRIPLVPGVLPLTDPRRIRRLCELN 240 Query: 228 NVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAIC 287 + +PA + D D E R +G + +V L G H YT NRAE S A+ Sbjct: 241 AIPLPAELLARLDAA--DDEERVAIGLTATLALVADLLAAGAPGIHLYTFNRAEASLAVL 298 Query: 288 HTL-GVRPG 295 G PG Sbjct: 299 EHAFGRVPG 307 >UniRef50_B2GHG1 Methylenetetrahydrofolate reductase n=1 Tax=Kocuria rhizophila DC2201 RepID=B2GHG1_KOCRD Length = 331 Score = 232 bits (593), Expect = 8e-60, Method: Composition-based stats. Identities = 85/300 (28%), Positives = 139/300 (46%), Gaps = 23/300 (7%) Query: 15 SLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSII 74 + + VSFE FPPR + T+W SID ++ P F SVT+G + G R + + Sbjct: 25 LVRRPRRSTLVSFEVFPPRPTTDPDTVWRSIDAMAQAGPDFFSVTHGHSGG-RGVSREAL 83 Query: 75 KGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------ 128 + ++ T H TC L ++G+R ++ALRGD P G+G+ Sbjct: 84 RHLRRTTRTPVMAHFTCGGTDRAGLERSVEHLLDDGVRDLLALRGDPPLGAGEWVTPPGG 143 Query: 129 EMYASDLVTLLKEVADFDIS-------------VAAYPEVHPEAKSAQADLLNLKRKVDA 175 AS+LV L+++V VA YP + +ADL +L K +A Sbjct: 144 IGRASELVRLIRDVERRRFGDGFRPGTRPLSVSVACYPSP-ARGRDFEADLASLWEKQEA 202 Query: 176 GANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWM 235 GA+ AITQ ++ E Y F +R S GI + ++ G++P++N K+ ++ ++T V +P + Sbjct: 203 GADYAITQVLYEPEDYAAFLERARSEGIHIPVVAGLMPLTNPKRLQRMTEITGVPVPERL 262 Query: 236 AQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPG 295 + + + G + ++ L G FH YT NR + + I L VR Sbjct: 263 TRFLTA--GSPDELRHRGTAATLTLIDDLLDLGCAGFHLYTFNRPDAALTILEHLRVRDA 320 >UniRef50_A8F6Y4 Methylenetetrahydrofolate reductase n=2 Tax=Thermotogaceae RepID=A8F6Y4_THELT Length = 315 Score = 232 bits (592), Expect = 1e-59, Method: Composition-based stats. Identities = 72/311 (23%), Positives = 126/311 (40%), Gaps = 33/311 (10%) Query: 12 LNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE----- 66 + + V+ +S E PP + + ++ +D L + F++VT A Sbjct: 3 FMKVIDCVKKGQILSIEILPPNRGQNIEEIYAVLDELMNFPISFINVTKHAPEMTYLELE 62 Query: 67 ----------RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVA 116 R T + + +R ++ PH+ C ++ + D G+R++ Sbjct: 63 DGIVKVPKVKRPGTVGMTAALMNRYNIDVVPHVLCFGMNKYQIEDMLIDLHLIGVRNLFV 122 Query: 117 LRGDLPP---GSGKPEMYASDLVTLLKEVA--------------DFDISVAAYPEVHPEA 159 +RG+ +ASDLV + + DF I VA YPE H EA Sbjct: 123 IRGEYENQTIEEKDSYSHASDLVKQISNMNMGEYLYPCENAKPTDFCIGVAGYPEKHFEA 182 Query: 160 KSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQ 219 + + D+ LK+K+++GA+ ITQ FD + Y +F +R I+V IIPG+ PV + K Sbjct: 183 PNIEEDMRYLKKKIESGADYVITQMIFDFDVYKKFVERARQLSINVPIIPGVKPVVSLKS 242 Query: 220 AKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNR 279 V IP + E +G +V+ L G H +T+ + Sbjct: 243 IYTIPRKFFVNIPESFVKQMQEAKTHREEF-QIGTKYMAKLVEKLLSSGAPGVHVFTMGK 301 Query: 280 AEMSYAICHTL 290 + + A+ + Sbjct: 302 GQSTKALLEAV 312 >UniRef50_A4XIN5 Methylenetetrahydrofolate reductase n=1 Tax=Caldicellulosiruptor saccharolyticus DSM 8903 RepID=A4XIN5_CALS8 Length = 604 Score = 227 bits (579), Expect = 3e-58, Method: Composition-based stats. Identities = 62/308 (20%), Positives = 125/308 (40%), Gaps = 38/308 (12%) Query: 8 QRDALNQSLAEVQ----GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN 63 Q+ L + +E+ + + E PP+ E+E+T + L V++ Sbjct: 306 QKSILKDTPSELSQKLGKKFVFTVEISPPKGIELEKT-KEGVKLLKEAGADTVNIADSPM 364 Query: 64 SGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP 123 + R ++ +K+ G+E+ H TC D L++ G+++++AL GD P Sbjct: 365 ARVRISPIALAHILKEELGVESILHFTCRDRNLISLQSELLGAAALGVKNVLALTGDPPS 424 Query: 124 GSGKP------EMYASDLVTL--------------LKEVADFDISVAAYPEVHPEAKSAQ 163 P ++ + LV + + + +F I VA ++ A Sbjct: 425 IGDYPQAKPVFDVNSEGLVLILNKLNSGTDYMGNPIGKATNFTIGVA----LNLNADDLD 480 Query: 164 ADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF 223 ++ LKRK++ GA+ TQ ++VE+ +F ++ I+ GILP+ + + A+ Sbjct: 481 KEIERLKRKIENGAHFIETQPIYEVEALEKFFEKVDFKLP--PILGGILPLRSSRHAEFL 538 Query: 224 -ADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAE 281 ++ + IP + + D + G IA ++V + V + + E Sbjct: 539 HNEVPGITIPDKIRERMKNSKDPVKE----GIEIACEIVDRIKEM-VSGIYIMPPFEKYE 593 Query: 282 MSYAICHT 289 M+ I Sbjct: 594 MAAEIIKR 601 >UniRef50_A9B657 Methylenetetrahydrofolate reductase n=1 Tax=Herpetosiphon aurantiacus ATCC 23779 RepID=A9B657_HERA2 Length = 617 Score = 227 bits (579), Expect = 4e-58, Method: Composition-based stats. Identities = 62/304 (20%), Positives = 126/304 (41%), Gaps = 27/304 (8%) Query: 6 ASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG 65 +++ L + LA+ G S E PP+ + L + ++ + F++V + Sbjct: 319 SAETTQLGRMLAD--GAFVTSVEIDPPKGHNPRRCLEGA-RQMQAAGVNFINVADSPMAR 375 Query: 66 ERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS 125 R + I+ + G+E H T D + L++ G+R+I+AL+GD P Sbjct: 376 VRMSALPMCNLIQQQVGMETILHFTTRDRSLMGLQSDLLGAHALGVRNILALKGDPPSFG 435 Query: 126 GKP---EMYASDLVTLLKEVADFDISV--AAYPEVHP-----------EAKSAQADLLNL 169 P ++ D + L+K +A + V A P A+ ++ L Sbjct: 436 AYPGTSGVFDVDTIGLVKVIAGMNSGVDTAGNDIGTPTNFLIGVALNINAEDPDWEIDRL 495 Query: 170 KRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTN 228 +KV AGA+ A+TQ +D RF D+ + + II G++PV +++ A ++ Sbjct: 496 HQKVAAGAHYAMTQISYDATELDRFLDKLG--PLPIPIILGLMPVQSYRHASFLHNEVPG 553 Query: 229 VRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAIC 287 + +P + + + + VG ++ +++ ++ + R EM+ + Sbjct: 554 ITLPKDVLERMKEAGANG---RAVGVQVSQEILAAAYDR-IQGVYIMPSFGRYEMAAEVL 609 Query: 288 HTLG 291 L Sbjct: 610 EVLK 613 >UniRef50_Q67LF9 Methylenetetrahydrofolate reductase n=1 Tax=Symbiobacterium thermophilum RepID=Q67LF9_SYMTH Length = 326 Score = 226 bits (576), Expect = 9e-58, Method: Composition-based stats. Identities = 69/312 (22%), Positives = 129/312 (41%), Gaps = 39/312 (12%) Query: 10 DALNQSLAEVQ-GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERD 68 A+ + + +Q G V+ E PPR + + TL + R + V+V + R Sbjct: 25 SAMARLMHRLQQGAFCVTVEIDPPRGAGVAGTLE-RVRRFGD-RVDAVNVADCPMANVRM 82 Query: 69 RTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP 128 ++ ++ +EA HLT D L+ G+R+I+ALRGD P P Sbjct: 83 SPITLAHLLQRDGQVEAIFHLTTRDRNIIGLQAELLGAAGLGVRNILALRGDDPSRGDHP 142 Query: 129 E---MYASDLVTLLK-----------------EVADFDISVAAYPEVHPEAKSAQADLLN 168 + ++ D + L++ + DF I A P A +A++ Sbjct: 143 DARGVFEVDTIGLIRLAAALNRGQTVSGTPLEQGTDFAIGCACNPA----AADLEAEVSR 198 Query: 169 LKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD-MT 227 L+ KV+AGA+ A TQ +D RF+ + + + I+ G+LP+ +++ A + + Sbjct: 199 LEEKVEAGAHFAQTQPVYDPRQVERFQAKLAGR-VKIPILYGVLPLKSYEFADRLNRTVP 257 Query: 228 NVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLN---RAEMSY 284 + IP W+ G + G + ++++ + V H + +N R Sbjct: 258 GIVIPGWVLDRMRG------RDEEEGLRLTAELLREIGPH-VHGVHIFPMNSARRVVAVL 310 Query: 285 AICHTLGVRPGL 296 + LG+R + Sbjct: 311 DLIDELGLRHSV 322 >UniRef50_B9L045 Methylenetetrahydrofolate reductase n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=B9L045_THERP Length = 624 Score = 225 bits (575), Expect = 9e-58, Method: Composition-based stats. Identities = 62/314 (19%), Positives = 118/314 (37%), Gaps = 36/314 (11%) Query: 1 MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY 60 M + L Q L + VS E PP+ + + + L + +F++V Sbjct: 314 MDAVAPEEPTRLRQKLGR---EFVVSVEIDPPKGLNPSKAIEGA-RLLRQVGVEFINVAD 369 Query: 61 GANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD 120 + R ++ ++ TG+E HLT D L+ G+R+I+AL GD Sbjct: 370 SPMARVRMSALALCVILQQETGVETILHLTTRDRNLMGLQADLLGAHALGVRNILALTGD 429 Query: 121 LPPGSGKPE---MYASDLVTLLKEVADFD-----------------ISVAAYPEVHPEAK 160 P P +Y D + L++ + +F I VA P Sbjct: 430 PPTLGDYPHATPVYDLDSIGLVRLLQNFRQGFDAGGASIGRPAMFTIGVAC----DPTRP 485 Query: 161 SAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDR--CVSAGIDVEIIPGILPVSNFK 218 Q ++ L K+ AGA+ +TQ FD ++ F + I+V ++ G+LP+ +F+ Sbjct: 486 DLQQEIERLHAKLAAGADFVMTQPVFDFSTWRNFVAQYEIRYGPIEVPVLLGVLPLQSFR 545 Query: 219 QAKKF-ADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT- 276 A ++ + + + + + G +A +++ V+ + Sbjct: 546 HASFLHNEVPGITLTEEALERMRRAGPNG---RAEGVAMARELIAEACEF-VQGIYLMPS 601 Query: 277 LNRAEMSYAICHTL 290 R E+ + L Sbjct: 602 FGRYEVVAEVLSAL 615 >UniRef50_D1CBD0 Methylenetetrahydrofolate reductase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CBD0_THET1 Length = 629 Score = 225 bits (573), Expect = 2e-57, Method: Composition-based stats. Identities = 66/307 (21%), Positives = 131/307 (42%), Gaps = 35/307 (11%) Query: 6 ASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG 65 + L Q++ +G+ VS E PP+ +TL + L+ K++++ + Sbjct: 317 EPEPTKLAQAIK--RGEFIVSVEVDPPKGLSARKTLEGA-KMLAEKGVKWINIGDSPMAR 373 Query: 66 ERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS 125 R ++ K I++ T +EA H T D +++ GIR+++AL GD P Sbjct: 374 VRMSCIALAKLIQETTPIEAIIHFTTRDRNVMAIQSDLIGAHAMGIRNVIALTGDPPSLG 433 Query: 126 GKPE---MYASDLVTLLKEVA-----------------DFDISVAAYPEVHPEAKSAQAD 165 P+ ++ D V L+K ++ F I+ A P AK + Sbjct: 434 DYPDATGVWDIDSVGLIKALSRMNEGFDLAGKQIGAKAGFCIAAAV----DPTAKDIEFQ 489 Query: 166 LLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-A 224 + + +K++AGA+ ++Q +DVE +F DR + I V I G+LP+ ++K A+ Sbjct: 490 IDRMWQKIEAGAHLIMSQPLYDVEDLQKFLDRVGN--IPVPFILGVLPLQSYKHAEFMHN 547 Query: 225 DMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMS 283 ++ + +P + + G +A ++V ++ V+ + R ++ Sbjct: 548 EVPGIYVPEHILDAMRRAGSNG---LQEGVRLAQELVHQ-AQHLVQGIYLMPSFGRYDVC 603 Query: 284 YAICHTL 290 + L Sbjct: 604 AQVFEAL 610 >UniRef50_A6W769 Methylenetetrahydrofolate reductase n=1 Tax=Kineococcus radiotolerans SRS30216 RepID=A6W769_KINRD Length = 298 Score = 224 bits (572), Expect = 3e-57, Method: Composition-based stats. Identities = 95/278 (34%), Positives = 137/278 (49%), Gaps = 7/278 (2%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 Q S EF P E Q W +++RL+ L+P F SVTYGA G R+ T + + RT Sbjct: 17 QRRFSVEFSPAHDEEGAQRQWRAVERLARLRPVFASVTYGAGGGTREGTVELASRLAART 76 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM-------YASD 134 L HLT + + +LR + RD G+ ++ALRGD P +A + Sbjct: 77 DLRPVAHLTAVGQSVPQLRGVVRDLLAGGVTDVLALRGDPDGDPRAPWRAHPQGLQHADE 136 Query: 135 LVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 LV L VAA+P HPE++ DL +L K AGA AI Q FDVE +LR Sbjct: 137 LVRLALAEGVRSAGVAAFPLGHPESRDLDEDLRHLLGKFAAGAGFAIAQLTFDVEDFLRL 196 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGA 254 RDR +AG ++PG+LPV++ K + +T+ P+W+ + DD + G Sbjct: 197 RDRLAAAGCTAPLVPGLLPVTSPKVLEVTRRLTDGHEPSWLQRRLAPFLDDRGAFREEGV 256 Query: 255 NIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 +A++ + L EGV H Y+LN A + LG+ Sbjct: 257 RLALEDGRRLLAEGVPLLHLYSLNAAGNVETLVEELGL 294 >UniRef50_B9MN09 Methylenetetrahydrofolate reductase n=2 Tax=root RepID=B9MN09_ANATD Length = 605 Score = 223 bits (569), Expect = 5e-57, Method: Composition-based stats. Identities = 60/309 (19%), Positives = 127/309 (41%), Gaps = 34/309 (11%) Query: 6 ASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG 65 A +D ++ ++ + + E PP+ E+E+T + L V++ + Sbjct: 309 AVLKDTPSELSQKLGKKFIFTVEISPPKGIELEKT-KEGVKLLKEAGADTVNIADSPMAR 367 Query: 66 ERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS 125 R ++ +K+ G+E+ H TC D L++ G+++++AL GD P Sbjct: 368 VRISPIALAHILKEELGMESILHFTCRDRNLISLQSELLGAAALGVKNVLALTGDPPSIG 427 Query: 126 GKP------EMYASDLVTL--------------LKEVADFDISVAAYPEVHPEAKSAQAD 165 P ++ + LV + + + +F I VA ++ A + Sbjct: 428 DHPQAKPVFDVNSEGLVLILSRLNNGTDYMGNPIGKATNFTIGVA----LNLNADDLGKE 483 Query: 166 LLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-A 224 + LK K++ GA+ TQ ++ E+ RF ++ I+ GILP+ + + A+ Sbjct: 484 IEKLKHKIENGAHFIETQPIYEPETLERFFEKVDFKLP--PILGGILPLRSPRHAEFLHN 541 Query: 225 DMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMS 283 ++ + IP + + + A+ G IA ++V+ + + V + + EM+ Sbjct: 542 EVPGITIPDKIRERMRTSKEPAKE----GVEIACEIVEKI-KHMVSGIYIMPPFEKYEMA 596 Query: 284 YAICHTLGV 292 I + Sbjct: 597 VEIIRNFKI 605 >UniRef50_Q2LQ11 Methylenetetrahydrofolate reductase n=1 Tax=Syntrophus aciditrophicus SB RepID=Q2LQ11_SYNAS Length = 618 Score = 221 bits (563), Expect = 3e-56, Method: Composition-based stats. Identities = 58/301 (19%), Positives = 116/301 (38%), Gaps = 23/301 (7%) Query: 7 SQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE 66 + + L + GQ S E PPR + + + R +++ G + Sbjct: 317 AAKSRLAAKI--CSGQKVTSVEILPPRAGD-FSNMLAKVRRCHEAGVDAINIPDGPRASA 373 Query: 67 RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG 126 R I G+E H C D +++ + G+ + + + GD P Sbjct: 374 RVSPMITALVILREVGIEPVVHYCCRDRNLIGMQSDLLGGYAVGLVNYLIITGDPPKLGN 433 Query: 127 KPE---MYASDLVTLLKEVADFDIS--VAAYP-----------EVHPEAKSAQADLLNLK 170 PE ++ D + L V + + + P +P A + ++ Sbjct: 434 CPEATGVFDVDSIGLTSVVHNLNSGWDIGGSPVDPPTGIFIGVGANPCAVDLEREIDRYF 493 Query: 171 RKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNV 229 +K++AGA AITQ FD ++ RF DR V ++ G+ P+ +++ A+ ++ V Sbjct: 494 QKIEAGAEFAITQPVFDEKALFRFLDRVEKHSKRVPVLAGVWPLLSYRNAEFMNNEVPGV 553 Query: 230 RIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMSYAICH 288 +P + + + E+++ G IA + + + V F LN E++ ++ Sbjct: 554 MVPREILERMARCETREESQRT-GIEIARAICEKIHER-VAGFQVCAPLNNVEIALSVLR 611 Query: 289 T 289 Sbjct: 612 K 612 >UniRef50_Q3M8T4 Methylenetetrahydrofolate reductase n=56 Tax=Cyanobacteria RepID=Q3M8T4_ANAVT Length = 357 Score = 220 bits (562), Expect = 4e-56, Method: Composition-based stats. Identities = 66/298 (22%), Positives = 111/298 (37%), Gaps = 27/298 (9%) Query: 15 SLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSII 74 S A G+ V+ E PP+ + + + V++T G+ + R + + Sbjct: 62 SKAAQAGEFLVTAEVAPPKGGNPTHMME--MAATLKGRVHAVNITDGSRAVLRMSSL-VA 118 Query: 75 KGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS- 133 I + G+E + C D L+ GIR+I+AL GD PE A Sbjct: 119 SAILLQQGIEPVCQMACRDRNRIALQADLMGAHALGIRNILALTGDPVKAGDHPEAKAVF 178 Query: 134 --DLVTLLKEVADFDISVAAY--------------PEVHPEAKSAQADLLNLKRKVDAGA 177 + V LL+ + + V V P+ S +RK++AGA Sbjct: 179 DLEAVRLLQLIRKMNQGVDCNDKPLTDGATDLFVGAAVDPQCASWSGLQSRFERKIEAGA 238 Query: 178 NRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD-MTNVRIPAWMA 236 +Q D E +F D+ S ++ GI + + K A+ + V IP + Sbjct: 239 QFFQSQLITDFERLEKFMDKIASVHKK-PVLAGIFLLKSAKNAQFINRCVPGVNIPEHII 297 Query: 237 QMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRP 294 + D E G IA + V+ ++R+ H + R ++ I GV P Sbjct: 298 ERLAKAKDPLEE----GVKIAAEQVQ-IARQLCHGVHMMAVKREDLIPQILDLAGVSP 350 >UniRef50_D0LSQ2 Methylenetetrahydrofolate reductase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LSQ2_HALO1 Length = 643 Score = 219 bits (559), Expect = 8e-56, Method: Composition-based stats. Identities = 63/300 (21%), Positives = 111/300 (37%), Gaps = 25/300 (8%) Query: 7 SQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE 66 + R L LA GQ VS E P ++ + L +I L V++ G + Sbjct: 329 AMRSRLGARLA--AGQFAVSVELTAPAGTDDSK-LLGNIRTLLEAGVDVVNIADGPRASA 385 Query: 67 RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG 126 R ++ ++ TG+E H+ D L GIR++V + GD P Sbjct: 386 RTGNLAVCTKLQATTGVEPILHVCTRDRNYLGLIAHLLGAHALGIRNMVIITGDPPKMGD 445 Query: 127 KPE---MYASDLVTLLKEVADFDIS---VAAYPEVH----------PEAKSAQADLLNLK 170 P +Y D + LL+ + + H P A + ++ L+ Sbjct: 446 YPFATPVYDVDSIGLLRMARTLNEGYDPAGKEIDGHTSFVLATGAEPAATDYEREMRRLE 505 Query: 171 RKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNV 229 K AGA +TQ +D RF D G+ ++ GILP+++ + A+ ++ + Sbjct: 506 DKRAAGAELVMTQPVYDPRVLERFLDDAEPLGL--PVMVGILPLASHRNAEFLHNEVPGM 563 Query: 230 RIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMSYAICH 288 +IP + + E + G IA + + V + NR + + Sbjct: 564 QIPQSYRDRMEKVGSGPEA-RAEGVRIAQE-ALEAVKHRVAGVYIMPPFNRVSSAIEVLD 621 >UniRef50_D0YUL0 Methylenetetrahydrofolate reductase n=1 Tax=Mobiluncus mulieris 28-1 RepID=D0YUL0_9ACTO Length = 350 Score = 219 bits (558), Expect = 1e-55, Method: Composition-based stats. Identities = 96/301 (31%), Positives = 140/301 (46%), Gaps = 18/301 (5%) Query: 4 FHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN 63 F + R A +S + VSFE +PPR + W IDRL P +VSVT+G + Sbjct: 25 FTSVSRGANPKSSRNPTRPVRVSFELYPPRNPDPFSQAWAGIDRLLDAHPDYVSVTFGTS 84 Query: 64 SGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP 123 + + S++ R G HLTC+ T EL T + + G+R +ALRGD P Sbjct: 85 NSTSASSQSVLAHALQRLGRPVLAHLTCVGKTRTELSTTITEMLDIGVRDFLALRGDNPK 144 Query: 124 G------SGKPEMYASDLVTLLKEV--------ADFDISVAAYPEVHPEAKSAQADLLNL 169 G + AS LVTLL+EV I+VAAYP A++ + L Sbjct: 145 GSVNWEPAPGEFSRASQLVTLLREVAAEYLGDARAISIAVAAYPAGTVSART--NAVAAL 202 Query: 170 KRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNV 229 K AGA+ AITQ F++ + Y D G+ + IIPGI+P ++ + ++ +T V Sbjct: 203 AEKQSAGADFAITQVFYNADDYGALLDSATYQGVSIPIIPGIIPFTDAARLQRLEGLTGV 262 Query: 230 RIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHT 289 +P+ + + D E R L G + +D V L + G HFYT NR + Sbjct: 263 SVPSRLQAI--SEISDPEERFLEGLSATLDFVNDLIQAGAPGLHFYTFNRPRPVLDLVEH 320 Query: 290 L 290 L Sbjct: 321 L 321 >UniRef50_A8Q9P3 Methylenetetrahydrofolate reductase n=1 Tax=Malassezia globosa CBS 7966 RepID=A8Q9P3_MALGO Length = 515 Score = 218 bits (557), Expect = 1e-55, Method: Composition-based stats. Identities = 67/261 (25%), Positives = 114/261 (43%), Gaps = 48/261 (18%) Query: 48 LSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYW 107 +S L P+FV +T+ A D T ++K ++ G+E HLTC + ++ R+ Sbjct: 1 MSKLGPEFVDITWNAGGRTSDMTTQLVKTVQTYFGVETCMHLTCTNMPRSKIEVALREAK 60 Query: 108 NNGIRHIVALRGDLPPGSGKP------EMYASDLVTLLKEVAD--FDISVAAYPEVHPEA 159 G R+++ALRGD P +A +LV ++E F I+VA +PE HPEA Sbjct: 61 EFGCRNVLALRGDPPAAGSPWEPHAAGFSHAFELVQYIREHYGDYFSIAVAGFPEGHPEA 120 Query: 160 -KSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFK 218 + ++ +LK+K+DAGA+ TQ F+D+++++ + R Sbjct: 121 VGGPELEMQHLKQKIDAGADFIFTQMFYDLDAFVNWTRRF-------------------- 160 Query: 219 QAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSRE---GVKDFHFY 275 D + +D E ++VG + DM K + + H Y Sbjct: 161 ----------------FHDALDPVKEDDEQVRIVGTRLVGDMCKKILEHPDLDIHGVHIY 204 Query: 276 TLNRAEMSYAICHTLGVRPGL 296 T+N S + LG+ P + Sbjct: 205 TMNLERGSRMLLEYLGLTPSV 225 >UniRef50_B0K6M8 Methylenetetrahydrofolate reductase n=14 Tax=Clostridia RepID=B0K6M8_THEPX Length = 303 Score = 218 bits (555), Expect = 2e-55, Method: Composition-based stats. Identities = 63/293 (21%), Positives = 119/293 (40%), Gaps = 39/293 (13%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 + + V+ E P+ ++ +T+ + +++T + R ++ ++D Sbjct: 13 KRKFVVTAEISTPKGVDITKTIEEARK--LKGIVDALNITDCPMANMRMSPIAVAHLLQD 70 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASDLV 136 +EA HLTC D L++ + G+R+I+AL GD P P+ +Y D + Sbjct: 71 HLNIEAIFHLTCRDRNLIGLQSELLGAYALGVRNILALTGDDPSRGDTPQAKGVYDVDSI 130 Query: 137 TLLKEV-----------------ADFDISVAAYPEVHPEAKSAQAD-LLNLKRKVDAGAN 178 LLK + +F A P + + L LK K++AGA Sbjct: 131 GLLKIISAFNRGYDYNGNKLDSPTEFCAGTTANPN------DLRDEALEKLKVKIEAGAE 184 Query: 179 RAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNVRIPAWMAQ 237 TQ +D E +F ++ + +V ++ GILP+ ++K A + + IP + + Sbjct: 185 FIQTQPVYDEEILFKFIEKIKN--FNVPLLIGILPLKSYKMAVNLNEKVPGIDIPEKVLE 242 Query: 238 MFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + + G NIA++ +K + E V H L + I + Sbjct: 243 RL------KDGGREEGINIAVEFIKRIRSE-VAGIHIMPLGSTNVVLEIISRV 288 >UniRef50_C1F3L2 Methylenetetrahydrofolate reductase n=2 Tax=Bacteria RepID=C1F3L2_ACIC5 Length = 636 Score = 218 bits (555), Expect = 2e-55, Method: Composition-based stats. Identities = 67/309 (21%), Positives = 121/309 (39%), Gaps = 34/309 (11%) Query: 8 QRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGER 67 QR L Q + + E PPR + ++ + + L+ L ++V + R Sbjct: 324 QRSRLGQMIHDRT--FVTMVEIVPPRGIDCQKEIDGA-TMLAGLGVHVINVPDSPRASAR 380 Query: 68 DRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK 127 S+ ++ ++G+E H TC D +++ + G+R+I+ L GD P Sbjct: 381 MSAQSLCIQLQQKSGIETLLHYTCRDRNVLSIQSDLLGASSIGLRNILCLTGDPPKLGNY 440 Query: 128 P------EMYASDLVTLLKEVA--------------DFDISVAAYPEVHPEAKSAQADLL 167 P ++ A LV +++ + F I AA +P ++ Sbjct: 441 PDATAVFDVDAIGLVNIVRRLNHGLDIGGNPIGASTGFTIGCAA----NPGVPDIDNEVR 496 Query: 168 NLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMT 227 KV+AGA AITQ FD+ F R G + +I GI P+++ + A+ + Sbjct: 497 RFAYKVEAGAEYAITQPVFDLRILESFLKRIE--GFRIPVIAGIWPLTSLRNAEFMRNDL 554 Query: 228 NVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMSYAI 286 V +P + E + G IA +M++ +R V+ R + + Sbjct: 555 RVSVPDSILLRMQQAAT-PELARAEGIRIAQEMLET-ARPMVEGVQVSAPFGRYTAAAEV 612 Query: 287 CHTLGVRPG 295 G+ PG Sbjct: 613 L--AGILPG 619 >UniRef50_UPI00015B5A5C PREDICTED: hypothetical protein n=1 Tax=Nasonia vitripennis RepID=UPI00015B5A5C Length = 326 Score = 217 bits (554), Expect = 3e-55, Method: Composition-based stats. Identities = 76/278 (27%), Positives = 126/278 (45%), Gaps = 14/278 (5%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN---SGERDRTHSIIKG 76 + + S+E FP + + Q + P F ++T+ ER + Sbjct: 44 RRESFCSYELFPTKCHGVYQGFFRDTQICE---PLFYALTWHEGWATGEERFPSLKSA-- 98 Query: 77 IKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLV 136 + H T + I GI +I AL+ +ASDLV Sbjct: 99 --EVFPRNTLLHCTAKGLKKTDAEMILTRALELGIANIFALQ-GDSGSDDGDFDHASDLV 155 Query: 137 TLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRF 194 ++E F I VA YPE+HP + S + D+ LK KVDAGA+ +TQFFF+ + +++F Sbjct: 156 KFIRERYGQQFSICVAGYPEMHPHSPSKELDIFYLKAKVDAGADFILTQFFFESQLFIKF 215 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGA 254 + C GI V IIPGI P ++ K K ++ + IP W+ + ++DD E + G Sbjct: 216 VNDCREVGISVPIIPGIYPFTDVKLLGKMIEICHTNIPDWIQEELRHIEDDDEAVRKFGI 275 Query: 255 NIAMDMVKILSRE-GVKDFHFYTLNRAEMSYAICHTLG 291 ++++ ++K + +H YTLNR+ + + L Sbjct: 276 DLSVKLIKEIRESAHFCGYHVYTLNRSFSAIEVHRQLN 313 >UniRef50_Q01QP4 Methylenetetrahydrofolate reductase n=2 Tax=Acidobacteria RepID=Q01QP4_SOLUE Length = 622 Score = 217 bits (552), Expect = 5e-55, Method: Composition-based stats. Identities = 58/301 (19%), Positives = 124/301 (41%), Gaps = 24/301 (7%) Query: 7 SQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE 66 +++ + LA G+ E PPR + + + + + ++V G + Sbjct: 326 AEKSQVGAKLA--AGKFVTFVEILPPRGVDATREIAGA-KLCAEHGIDAINVPDGPRASA 382 Query: 67 RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG 126 R + I+ + G+EA H C D +++ G+R+++ + GD P Sbjct: 383 RMSAQVTCQLIQAQAGIEAVNHFCCRDRNILGIQSELLGTHGAGVRNLICITGDPPRMGA 442 Query: 127 KPE---MYASDLVTLLKEVADFDIS--VAAYPEV-----------HPEAKSAQADLLNLK 170 P+ ++ D + L+ V + + + P +P A + ++ + Sbjct: 443 YPDATAVFDVDAIGLVNIVRNLNHGLDIGGNPMGSQTALLIGVGANPGALNMDEEIRRFE 502 Query: 171 RKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVR 230 KV+AGA +TQ FD++ F R + + ++ GI P+++++ A+ + V Sbjct: 503 WKVEAGAEYVVTQPVFDLDLLEAFLKRIE--HVKIPVLCGIWPLTSYRNAEFMVNELRVP 560 Query: 231 IPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMSYAICHT 289 +P + + D+AE + G IA +MV +S+ V+ R +M+ + Sbjct: 561 VPEMFMERMRRV-DNAEKAREEGVAIAREMVARVSKM-VQGAQLSAPFGRYQMAIDVADA 618 Query: 290 L 290 + Sbjct: 619 I 619 >UniRef50_B7AVK8 Methylenetetrahydrofolate reductase n=1 Tax=Bacteroides pectinophilus ATCC 43243 RepID=B7AVK8_9BACE Length = 218 Score = 215 bits (547), Expect = 2e-54, Method: Composition-based stats. Identities = 68/207 (32%), Positives = 110/207 (53%), Gaps = 5/207 (2%) Query: 48 LSSLKPKFVSVTYGANSG-ERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDY 106 + +P ++SVT+GA ++T + + IK++ +E HLTC+ E+ R+ Sbjct: 1 MCDCRPDYISVTFGAGGSSNNNKTIQLARKIKEKYHVEPVVHLTCLCYNRAEIDEFVREL 60 Query: 107 WNNGIRHIVALRGD--LPPGSGKPEMYASDLVTLLKEVAD--FDISVAAYPEVHPEAKSA 162 GI +I+ALRGD + + +ASDL+ L+ F I+ A YP+VHPE + Sbjct: 61 TAEGIENILALRGDRNPDVPAKEDFAHASDLIKYLRATTGDRFCIAGACYPDVHPETGNR 120 Query: 163 QADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKK 222 D+ NLK K DAGA+ I+Q FFD +++L+F C A I+V I+PGI+P N Q ++ Sbjct: 121 VDDINNLKIKTDAGADILISQLFFDNDTFLQFVSDCRRARIEVPIVPGIMPCINAAQIQR 180 Query: 223 FADMTNVRIPAWMAQMFDGLDDDAETR 249 M + P ++ D+ + Sbjct: 181 MVTMCGAKFPERFRKLIRKYGDNKDAL 207 >UniRef50_A8ZTK4 Methylenetetrahydrofolate reductase n=24 Tax=Bacteria RepID=A8ZTK4_DESOH Length = 321 Score = 214 bits (546), Expect = 2e-54, Method: Composition-based stats. Identities = 60/301 (19%), Positives = 114/301 (37%), Gaps = 34/301 (11%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 G + E PPR +++E+ + R ++T + R + + + Sbjct: 12 RAGHFAFTGEIGPPRGTDVEEVKEKA--RFLKGNVDMANITDNQTAVVRMSSWATSLVVM 69 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY------A 132 + G+E + C D ++ + GIR+I+AL GD P + Sbjct: 70 EE-GVEPNYQMVCRDRNRLAMQADILGAYALGIRNILALSGDHQQFGDHPFAKGVYDLDS 128 Query: 133 SDLVTLLKEVAD---------------FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGA 177 LV ++K + D I AA +P A+ + + L +K+DAGA Sbjct: 129 IQLVNMIKNMRDEGKFQGGADISHPPKMFIGAAA----NPFAEPYEWRVHRLAKKIDAGA 184 Query: 178 NRAITQFFFDVESYLRFRDRCVSAGIDVEIIP--GILPVSNFKQAKKFA-DMTNVRIPAW 234 + TQ F++E + + + G+ +I GI P+ + A+ + + +P Sbjct: 185 DFVQTQCIFNMERFREWIRQANDMGLTEKIYILGGITPMKSIGMARYMQKKVPGMDVPEA 244 Query: 235 MAQMFDGLDDDAETRKLVGANIAMDMVKILSR-EGVKDFHFYTLNRAEMSYAICHTLGVR 293 + + G+ D + G IA + ++ L +GV H + I G+ Sbjct: 245 IIKRLQGV--DKKEVANEGIKIACEQIQELKETKGVAGVHLMAIEWEHKVPEIAEKAGML 302 Query: 294 P 294 P Sbjct: 303 P 303 >UniRef50_Q2RJ84 Methylenetetrahydrofolate reductase n=2 Tax=Bacteria RepID=Q2RJ84_MOOTA Length = 306 Score = 211 bits (537), Expect = 3e-53, Method: Composition-based stats. Identities = 64/301 (21%), Positives = 124/301 (41%), Gaps = 37/301 (12%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 QGQ VS E PP+ ++ + ++ L +++T + R + + + Sbjct: 12 QGQFLVSGEIGPPKHADPTEIKKHAA--LLKDYVDAMNLTDNQTAIVRLSSIAAGVHVL- 68 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYAS 133 + G E +T D L++ ++ G+R+++ L GD P ++ + Sbjct: 69 QAGGEPIIQMTVRDRNRIALQSDLLGAYSLGMRNVLCLSGDHQSFGNHPTAKNVHDVDSL 128 Query: 134 DLVTLLKEVAD----------------FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGA 177 L+ ++K++ D F I AA P P + ++ L++K++AGA Sbjct: 129 QLIRIVKDLRDEKKFACGEEIKGQEPRFFIGAAANPFADP----FEFRVMRLEKKINAGA 184 Query: 178 NRAITQFFFDVESYLRFRDRCVSAGI--DVEIIPGILPVSNFKQAKKFAD-MTNVRIPAW 234 + TQ FD+E + RF G+ +II G++P+ + + AK + + +P Sbjct: 185 DFIQTQCIFDMERFERFMALVRERGLHKRAKIIAGVMPLKSARAAKYMQQSVAGMIVPDE 244 Query: 235 MAQMFDGLDDDAETRKLVGANIAMDMVKILSR-EGVKDFHFYTLNRAEMSYAICHTLGVR 293 + + D K G I ++ +K L EGV H + ++ I G+ Sbjct: 245 IVNRMEKASDP----KAEGVAICVEQIKHLQSIEGVAGVHIMAVMWEDIIPTIVKEAGLY 300 Query: 294 P 294 P Sbjct: 301 P 301 >UniRef50_A9FZY9 Methylenetetrahydrofolate reductase n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9FZY9_SORC5 Length = 624 Score = 210 bits (536), Expect = 3e-53, Method: Composition-based stats. Identities = 65/303 (21%), Positives = 117/303 (38%), Gaps = 26/303 (8%) Query: 8 QRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGER 67 +R L +A G+ VS E P E L ++ L V+V G + R Sbjct: 327 ERSPLAAKIA--AGKFVVSVEVNPAPGLNPESAL-SAAKMLIDSGVDVVNVADGPRATAR 383 Query: 68 DRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK 127 + + R G+E H+ D GI+++V + GD P Sbjct: 384 MTNLAFCSLLVQRYGIEPILHVCGRDRNLIGQMAHLLGAHAIGIKNLVIITGDPPKVGDY 443 Query: 128 PE---MYASDLVTLLKEVADFDISV--AAYP------------EVHPEAKSAQADLLNLK 170 PE +Y D + LL + + + A P + P A+ ++ L+ Sbjct: 444 PEATAVYDLDSIGLLHMASTMNRGLDPAGKPIPGGKTSFLLATGLEPGAQDLDKEIARLE 503 Query: 171 RKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNV 229 RK AGA+ +TQ F + + R G+ ++ G+LP+ + K A+ ++ + Sbjct: 504 RKRAAGADIIMTQPVFHQDLLEKVLRRIEHLGM--PVLVGVLPLVSHKNAEFLHNEVPGM 561 Query: 230 RIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMSYAICH 288 +IP + + + E RK G IA +M+ + V+ + L + E++ + Sbjct: 562 QIPEEIRERMRKVPAGPEARKE-GVKIAREMLFSVRDR-VQGAYLMPPLGKYELALEVLD 619 Query: 289 TLG 291 L Sbjct: 620 GLK 622 >UniRef50_C2KSD1 Methylenetetrahydrofolate reductase n=2 Tax=Mobiluncus RepID=C2KSD1_9ACTO Length = 307 Score = 210 bits (534), Expect = 6e-53, Method: Composition-based stats. Identities = 92/282 (32%), Positives = 134/282 (47%), Gaps = 18/282 (6%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 + VSFE +PPR + W IDRL P +VSVT+G ++ + S++ R G Sbjct: 1 MRVSFELYPPRNPDPFSQAWAGIDRLLDAHPDYVSVTFGTSNSTSASSQSVLAHALQRLG 60 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG------SGKPEMYASDLV 136 HLTC+ T EL T + + G+R +ALRGD P G + AS LV Sbjct: 61 RPVLAHLTCVGKTRAELSTTITEMLDIGVRDFLALRGDNPKGSVNWEPAPGEFSRASQLV 120 Query: 137 TLLKEV--------ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDV 188 TLL+EV I+VAAYP A++ + L K AGA+ AITQ F++ Sbjct: 121 TLLREVAAEYLGDARAISIAVAAYPAGTVSART--NAVAALAEKQSAGADFAITQVFYNA 178 Query: 189 ESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAET 248 + Y D G+ + IIPGI+P ++ + ++ +T V +P+ + + D E Sbjct: 179 DDYGALLDSATYQGVSIPIIPGIIPFTDAARLQRLEGLTGVSVPSRLQAI--SEISDPEE 236 Query: 249 RKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 R L G + +D V L + G HFYT NR + L Sbjct: 237 RFLEGLSATLDFVNDLIQAGAPGLHFYTFNRPRPVLDLVEHL 278 >UniRef50_C7M2P8 Methylenetetrahydrofolate reductase n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7M2P8_ACIFD Length = 284 Score = 209 bits (533), Expect = 7e-53, Method: Composition-based stats. Identities = 82/278 (29%), Positives = 133/278 (47%), Gaps = 12/278 (4%) Query: 18 EVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGI 77 + G+ S E +P RTS+ E L ++D L SL P FVSVTYGA R + ++I+ + Sbjct: 6 DRYGERVCSVELWPARTSDQEHRLTATLDVLRSLPPAFVSVTYGAFGSSRHESLALIERV 65 Query: 78 KDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM-----YA 132 G HL +P++L + G ++ALRGD P +A Sbjct: 66 LAD-GHRVLAHLAVAGHSPEQLVALLTHVERLGADGVLALRGDPPLDDPDDRARFVGRHA 124 Query: 133 SDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYL 192 +LV L ++ + VA +P HPEA+S + DL + K+ A A+ ITQF+F+ + Sbjct: 125 LELVELARQHTQLSVGVALHPSGHPEARSLEDDLDHQAAKL-ARADFGITQFYFEAAALT 183 Query: 193 RFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV 252 R R G+ +IPG+L + +Q + +M VR+P + + +G D A R +V Sbjct: 184 RLRGALRGRGVTRPVIPGLLVPRSPRQLLRMGEMAAVRVPRELVEALEGPDGPARARTVV 243 Query: 253 GANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 G ++ EG H +++N+ E + + L Sbjct: 244 G-----ELASAALEEGSPGVHLFSMNQPETTAWLLERL 276 >UniRef50_B5YJV3 Methylenetetrahydrofolate reductase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=B5YJV3_THEYD Length = 295 Score = 209 bits (533), Expect = 8e-53, Method: Composition-based stats. Identities = 59/301 (19%), Positives = 112/301 (37%), Gaps = 29/301 (9%) Query: 13 NQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLK--PKFVSVTYGANSGERDRT 70 N + G ++ E PP+ + + + +L LK V+ T ++ R + Sbjct: 3 NLRKRLMSGDFVITVEITPPKGPD----ITGMVKKLEELKTMVDAVNFTDNPSARMRLCS 58 Query: 71 HSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE- 129 + K + G E + C D +++ GIR+++ + GD P E Sbjct: 59 LAACK-LSMDIGFEPVLQMACRDRNRLAIQSDLLGAHALGIRNLLVMTGDHPVWGDHREA 117 Query: 130 --MYASDLVTLLKEVADFDISVAAYPEV-------------HPEAKSAQADLLNLKRKVD 174 +Y D L+K V + + + +P A+ L ++K+ Sbjct: 118 KPVYDIDSSILVKLVGNLNSGLDINGNKLNGKTEFFCGAVVNPNAEPLMPQLKRFEQKLK 177 Query: 175 AGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNVRIPA 233 GA TQ F++E RF D S + ++I GI+ + K A + V +P+ Sbjct: 178 MGAEFFQTQMIFEIEKLERFIDY--SKKFNTKVIAGIVLIRTKKMLHYLASKVPGVVMPS 235 Query: 234 WMAQMFDGLDDDAETRKLVGANIAMDMVKILSRE-GVKDFHFYTLNRAEMSYAICHTLGV 292 W+ + L + E + G + A ++ L H ++ E + L + Sbjct: 236 WLIDKIERL--NDEDVEKFGVDFAGSIILNLMERKLCDGVHIMAFSKVEEVKNLLDFLKI 293 Query: 293 R 293 R Sbjct: 294 R 294 >UniRef50_D1N227 Methylenetetrahydrofolate reductase n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N227_9BACT Length = 605 Score = 209 bits (532), Expect = 1e-52, Method: Composition-based stats. Identities = 63/299 (21%), Positives = 112/299 (37%), Gaps = 25/299 (8%) Query: 7 SQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE 66 ++R + LA+ G E PPR ++ T+ + + V++ G + Sbjct: 313 AERSRIGCKLAD--GAFIKLVEITPPRGFDLTGTIAGAAKC-KAAGIDAVNLPDGPRASA 369 Query: 67 RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG 126 R I+ G+E H C D + L+ GI +I+ + GD P Sbjct: 370 RISPLVTALEIQRNAGIETILHCCCRDKSLIGLQADLLGCAGVGINNILFITGDPPKLGD 429 Query: 127 KPE---MYASDLVTLLKEVADFDISV--AAYP-----------EVHPEAKSAQADLLNLK 170 P ++ D V L+K + V P P A + + Sbjct: 430 YPFSSGVFDVDSVGLVKIQKRMNQGVDLGGKPLNAVTKMVIGVGADPNAIDLEREYRRTC 489 Query: 171 RKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNV 229 KV+AGA ITQ F E+ F DR A ++V +I GI P+++ + A+ ++ V Sbjct: 490 EKVEAGAEFIITQPVFAPEALFVFLDRV--AHLNVPVIAGIWPLTSLRNAEFMRTEVPGV 547 Query: 230 RIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMSYAIC 287 +P + + D+ E ++ G IA + V + V+ + + + Sbjct: 548 VVPDAVMERM-AADESKEAQREAGIAIARESVAAIRSR-VRGIQVSAPFGNVDTALRVL 604 >UniRef50_A7VPD0 Methylenetetrahydrofolate reductase n=1 Tax=Clostridium leptum DSM 753 RepID=A7VPD0_9CLOT Length = 600 Score = 208 bits (531), Expect = 1e-52, Method: Composition-based stats. Identities = 64/300 (21%), Positives = 123/300 (41%), Gaps = 27/300 (9%) Query: 5 HASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANS 64 A Q Q L +G ++ E PP S L + L + V+++ + Sbjct: 309 SAPQESRFAQKLR--KGDFVMAAELDPPYGSR-VDKLLTACRVLQNSGVDIVTISDSPMA 365 Query: 65 GERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG 124 + ++ TG+E PH C D + LR + IR I+A+ GD P Sbjct: 366 RVKLDPVVCGAKLQRETGMEVLPHFCCRDRNVNALRAMLLGAQCENIRTILAVTGDHVPE 425 Query: 125 SGK------PEMYASDLVTLLKEVAD-------FDISVAAYPEVHPEAKSAQADLLNLKR 171 + + ++ L+ ++ ++ F I A +P + +A+L L++ Sbjct: 426 LDRGYIKPVFNVTSAKLMEMISQMNQDVFADSPFTIGGA----FNPNVANPKAELARLEK 481 Query: 172 KVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVR 230 K+ AGA +TQ FD ++ + + +++ GI+P+ +++ A ++ ++ Sbjct: 482 KLKAGAVFFLTQPVFDEGRISTVKE---AREMGAKMLLGIMPLVSYRNAVYMNNEVPGIQ 538 Query: 231 IPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHT 289 IP F E ++ G IA+++ + L R F+F T NRAE+ + Sbjct: 539 IPTAYVNRFSPEMSREEAQRT-GIEIALEIAESL-RPHADGFYFMTPFNRAEIVAELIEK 596 >UniRef50_A5ZMW8 Methylenetetrahydrofolate reductase n=4 Tax=Clostridiales RepID=A5ZMW8_9FIRM Length = 292 Score = 206 bits (525), Expect = 7e-52, Method: Composition-based stats. Identities = 59/287 (20%), Positives = 110/287 (38%), Gaps = 25/287 (8%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 +G+ VS E PP+ +++ + + L V+VT +S R + ++ K +K Sbjct: 9 RGEFVVSAEVGPPKGIHVDELVEEAKTYLKD--VHAVNVTDNQSSVMRLGSLAMCKVLK- 65 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASDLV 136 G++ L C D L + GI +I+ L GD P+ ++ D V Sbjct: 66 DAGMDPIFQLACRDRNRIALESDLLSAAMFGIENILCLTGDHTKMGDHPQAKPVFDLDSV 125 Query: 137 TLLKEVADFDISV-------AAYPEV-------HPEAKSAQADLLNLKRKVDAGANRAIT 182 +LL V + V P P + S A L ++RKV AGA+ T Sbjct: 126 SLLHTVKLLESGVDLGGNELVGEPPKFSKGAVVSPCSDSVDAQLAKMERKVAAGADYFQT 185 Query: 183 QFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDG 241 Q F+ E +++F ++ G + GI+ + + ++ + +P M + Sbjct: 186 QAVFEPEKFIKFMEKAKQFGK--PVQVGIIIPKSVGMVRFMNNNVAGIHVPDEMIEELKA 243 Query: 242 LDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICH 288 + + + G IA ++K + + H L + Sbjct: 244 DKEKTKAG-ITGVEIAARIIKE-CKPYCQGVHIMALGWESKIPDLLK 288 >UniRef50_B1HTR8 Methylenetetrahydrofolate reductase n=95 Tax=Bacilli RepID=B1HTR8_LYSSC Length = 647 Score = 206 bits (524), Expect = 8e-52, Method: Composition-based stats. Identities = 51/303 (16%), Positives = 119/303 (39%), Gaps = 24/303 (7%) Query: 7 SQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE 66 ++ +V+ + +V E PR E + +L V + + + Sbjct: 336 AEPAKYEPLHEKVKRERSVIVELDTPRHLE-IEGFLEGAKQLYEAGADVVMMADNSLASP 394 Query: 67 RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG 126 R ++ +K G+ H+TC D L++ GI ++A+ GD Sbjct: 395 RISNIAMGALLKSTNGVRPLTHITCRDRNLIGLQSHLMGLNALGIHDVLAVTGDPTKVGD 454 Query: 127 KP------EMYASDLVTLLKEVADFDISVAAYP-----------EVHPEAKSAQADLLNL 169 P ++ + +L+ L+K++ + +S + P +P + + L Sbjct: 455 FPGATSVYDVSSMELIQLIKQL-NEGVSFSGKPLRKKANFSVAAAFNPNVRVLDRAVARL 513 Query: 170 KRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTN 228 ++K++ GA+ I+Q + E + + + + I GI+PV+++K A+ ++ Sbjct: 514 EKKIEHGADYFISQPVYTKEKMIEIYEA--TKHLQAPIYIGIMPVTSYKSAEFLHHEVPG 571 Query: 229 VRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAIC 287 +++ +D E L G IA ++V ++ + + T R +++ + Sbjct: 572 IKLSEDALARMKACGEDKERATLEGIAIAKELV-EVAAQYFNGIYLITPFLRYDVTLELM 630 Query: 288 HTL 290 + Sbjct: 631 KYI 633 >UniRef50_O06745 5,10-methylenetetrahydrofolate reductase n=78 Tax=Bacillus RepID=YITJ_BACSU Length = 612 Score = 204 bits (519), Expect = 3e-51, Method: Composition-based stats. Identities = 45/310 (14%), Positives = 117/310 (37%), Gaps = 31/310 (10%) Query: 4 FHASQRDALNQSLAE-VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGA 62 F + + L E + ++ E PP+ ++ L +++ + Sbjct: 298 FISVHHERTEPGLDEIAAKKRSIIVELDPPKKL-SFDKFLSAAAELKEAGIDALTLADNS 356 Query: 63 NSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP 122 + R + +K + + + H+TC D L++ G+ ++A+ GD Sbjct: 357 LATPRISNVACGALVKQQLDMRSLVHITCRDRNIIGLQSHLMGLDTLGLNDVLAITGDPS 416 Query: 123 PGSGKP------EMYASDLVTLLKEVA--------------DFDISVAAYPEVHPEAKSA 162 P ++ + DL+ L+K+ +F ++ A +P + Sbjct: 417 KIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSGKPLGKKTNFSVAAA----FNPNVRHL 472 Query: 163 QADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKK 222 + L++K+D GA+ ++Q + + + + + I GI+P+++ + A+ Sbjct: 473 DKAVKRLEKKIDCGADYFVSQPVYSEQQLVDI--HNETKHLKTPIYIGIMPLTSSRNAEF 530 Query: 223 F-ADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRA 280 ++ +++ + + +D E +K G IA ++ + T R+ Sbjct: 531 IHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIARSLLDTACEL-FNGIYLITPFLRS 589 Query: 281 EMSYAICHTL 290 +++ + + Sbjct: 590 DLTAELTSYI 599 >UniRef50_Q8KTS2 Methylenetetrahydrofolate reductase n=1 Tax=Candidatus Tremblaya princeps RepID=Q8KTS2_TREPR Length = 300 Score = 204 bits (519), Expect = 4e-51, Method: Composition-based stats. Identities = 87/273 (31%), Positives = 134/273 (49%), Gaps = 13/273 (4%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 +SFEFF PR+ L + LS P+FVSVT + G++ +I + Sbjct: 24 PGLSFEFFAPRSHAGSIRLMCAQQVLSRFVPRFVSVTRSTSLGQQAHIDTIASTL--SVF 81 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD---LPPGSGKPEMYASDLVTLL 139 APH+ L R Y GIRH+V LRGD P G PE LV+++ Sbjct: 82 PRTAPHVLFCQCPR-ALARELRAYELLGIRHLVLLRGDNGIAPGSIGAPE-----LVSMV 135 Query: 140 KEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDR 197 + F I VAAYP+ HP + + D+ L RKV GAN AITQ F++ ++Y R +D Sbjct: 136 RRSYGEAFYIDVAAYPDGHPMSSTIFEDVRALARKVRCGANSAITQCFYNPDAYYRLQDE 195 Query: 198 CVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIA 257 G+ + + PGI+PV + +F + V +PAW+ + + L + + G ++A Sbjct: 196 LQRLGVSLPVTPGIMPVLSHDYMSRFILPSGVDVPAWILKRLEALRYCSASVLEFGTDVA 255 Query: 258 MDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + + + L+ G DFH YT+N + +C + Sbjct: 256 LSLCESLAARGASDFHLYTMNDHRAVWRVCEHV 288 >UniRef50_A4J5C2 Methylenetetrahydrofolate reductase n=5 Tax=Clostridiales RepID=A4J5C2_DESRM Length = 598 Score = 203 bits (517), Expect = 5e-51, Method: Composition-based stats. Identities = 61/286 (21%), Positives = 126/286 (44%), Gaps = 20/286 (6%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 +G+ ++ E PP ++ + L N+ +++ + R + I IK Sbjct: 317 RKGKFVIAVELDPPFNADTDLILQNAW-ICKDHGVDAITIADSPMARARADSIMIAAKIK 375 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM------YA 132 G+E PHL C D + L++ + IR+++A+ GD + K ++ + Sbjct: 376 REVGIEVLPHLCCRDKNLNALKSALLAGYIENIRNVLAITGDPVAIADKNDIKGVFNLNS 435 Query: 133 SDLVTLLKEVADF-----DISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFD 187 L+ L+ + I+V ++ +A+L + +K+++GA +TQ F Sbjct: 436 MKLIQLISTMNKELFPEDPINVGG--ALNLNLLKPEAELAKMVKKINSGATFFLTQPIF- 492 Query: 188 VESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDDDA 246 E Y+ R ++ ++I+ GI+P+ ++K A ++ ++IP + ++ Sbjct: 493 -EDYVINILRLINKNDGIKILGGIMPLVSYKNALFLNNEVAGIKIPERIINKYNSNMGKD 551 Query: 247 ETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTLG 291 E +++G IA+++ + V F+F T NR EM I L Sbjct: 552 EA-EIIGIEIAVEIANKIKES-VDGFYFITPFNRVEMIMKIIKKLK 595 >UniRef50_C6D4G9 Methylenetetrahydrofolate reductase n=12 Tax=cellular organisms RepID=C6D4G9_PAESJ Length = 632 Score = 203 bits (516), Expect = 7e-51, Method: Composition-based stats. Identities = 48/293 (16%), Positives = 115/293 (39%), Gaps = 24/293 (8%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + V E PPR ++ + + + +++ + + R ++ +K+R Sbjct: 343 RHAVIVELDPPRDLDITK-FMAGAAAIKACGADAITMADNSLAVTRMSNLALAALVKERI 401 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASDLVTL 138 GL H+ C D ++ GI H++A+ GD P+ +Y + Sbjct: 402 GLRPLVHIACRDRNLIGTQSHLMGLDALGIDHVLAVTGDPARFGDLPDSSSVYDLTSFEM 461 Query: 139 LKEVADFDISVA--AYP-----------EVHPEAKSAQADLLNLKRKVDAGANRAITQFF 185 ++ + +A P +P K + L++K+ +GA+ +TQ Sbjct: 462 IRMTKQLNDGIAFSGKPLKQKAKFVVGAAFNPNVKHLDKAVQRLEKKIASGADYIMTQPV 521 Query: 186 FDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDD 244 +D + + + + V + GI+P+++ + A+ ++ +++ + + GL+ Sbjct: 522 YDPVLIEKIAEA--TKHLPVPVFIGIMPLASGRNAEYLHNEVPGIQLSDEVRKRMAGLEG 579 Query: 245 DAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTLGVRPGL 296 + G I+ +++ R K +F T EM+ + + + G+ Sbjct: 580 --AEGRAEGVRISRELLDTAIRH-FKGIYFMTPFMFYEMAAELTDYVWAKTGV 629 >UniRef50_C6VPC5 Methylenetetrahydrofolate reductase n=3 Tax=Lactobacillus plantarum RepID=C6VPC5_LACPJ Length = 618 Score = 203 bits (516), Expect = 7e-51, Method: Composition-based stats. Identities = 56/308 (18%), Positives = 121/308 (39%), Gaps = 29/308 (9%) Query: 5 HASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANS 64 + ++ L +V Q E PPR + + + +RL + ++++ + + Sbjct: 309 TLVTTKSQHRFLQKVATQKTALVELDPPRDFDTTK-FFRGAERLKAAGVDGITLSDNSLA 367 Query: 65 GERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG 124 R +I +K G+ HLT D L++ + GI I+A+ GD Sbjct: 368 TVRIANTTIAAQLKLNYGITPIVHLTTRDHNLIGLQSEIMGLHSLGIEDILAITGDPAKL 427 Query: 125 SGKP------EMYASDLVTLLKEVA--------------DFDISVAAYPEVHPEAKSAQA 164 P ++ + +L+ L+K+ DF ++ A P + + S ++ Sbjct: 428 GDFPGATSVSDVRSVELMKLIKQFNSGIGPTGKSLKEASDFRVAGAFNPNAYRTSISTKS 487 Query: 165 DLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF- 223 + RK+ G + ITQ +D+ + D + ++V + G++P+ + + A+ Sbjct: 488 ----ISRKLSYGCDYIITQPVYDLANVDALADALAANHVNVPVFVGVMPLVSRRNAEFLH 543 Query: 224 ADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEM 282 ++ +RIP + + + VG IA +++ + H T NR + Sbjct: 544 HEVHGIRIPEPILTRMAEAEQTGNE-RAVGIAIAKELIDGICAR-FNGVHIVTPFNRFKT 601 Query: 283 SYAICHTL 290 + + Sbjct: 602 VIELVDYI 609 >UniRef50_A5UUW4 Methylenetetrahydrofolate reductase n=5 Tax=Chloroflexaceae RepID=A5UUW4_ROSS1 Length = 309 Score = 203 bits (516), Expect = 8e-51, Method: Composition-based stats. Identities = 61/305 (20%), Positives = 116/305 (38%), Gaps = 34/305 (11%) Query: 10 DALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLS---SLKPKFVSVTYGANSGE 66 + L G I V+ E PPR + +++RL+ +++T Sbjct: 5 SEFQRRL--QAGHIVVTGEIAPPRGAS-----RATVERLALGLRDAVDAINLTDNQRGLG 57 Query: 67 RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG 126 R I + GLE +TC L+ GI + +A+ GD P Sbjct: 58 RMSALG-AGIIIRQLGLEPIVQMTCQHRNRIALQADVLSGAACGITNFLAMTGDHPKIGD 116 Query: 127 KPEM------YASDLVTLLKEVAD---FDISVAA-----YPEVHPEAKSAQADLLNLKRK 172 P+ + L+ +L+ + D F VA + + + + L+RK Sbjct: 117 HPDAKNVLDLNSFQLLKMLRTMRDEGKFQSGVALTEAPRFFLGGVANPNIER-VARLERK 175 Query: 173 VDAGANRAITQFFFDVESYLRFRDRCVSAGIDVE--IIPGILPVSNFKQAKKFA-DMTNV 229 + GA TQ FD++ + ++ +AG+ + I+ GI+ V + + A+ + Sbjct: 176 IQFGAEFIQTQILFDLDRFRQWMADARAAGLHQKAYILAGIMVVKSAQSARFLRDHLPGS 235 Query: 230 RIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSR-EGVKDFHFYTLNRAEMSYAICH 288 R+P W+ + + E G IA ++ + L EGV+ H ++ + + Sbjct: 236 RVPEWVIERMERAAHPEEE----GIAIAAELAQELLAIEGVRGVHIMSVGWTKAIPQVVA 291 Query: 289 TLGVR 293 G+ Sbjct: 292 RAGLI 296 >UniRef50_A1AKP7 Methylenetetrahydrofolate reductase n=10 Tax=Desulfuromonadales RepID=A1AKP7_PELPD Length = 615 Score = 202 bits (515), Expect = 1e-50, Method: Composition-based stats. Identities = 51/291 (17%), Positives = 110/291 (37%), Gaps = 32/291 (10%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + ++ E PP+ + + + RL +++ + R ++ I+ + Sbjct: 323 RKLITVELDPPKGLDCSRIIEGC-RRLKRAGVDAINLAENPLARPRMGNIALGSLIQQQV 381 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK------PEMYASDL 135 G+ H+T D +++ GIR ++A+ GD ++++ L Sbjct: 382 GIPVIIHVTGRDRNLIGMQSDLMGASLLGIRSVLAVTGDPATMGDHAGATSVFDLHSLTL 441 Query: 136 VTLLKEVA--------------DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAI 181 + LL ++ F I A +P A+ L++KV GA A Sbjct: 442 IKLLADLNRGVNAMGNPIGGGAGFTIGAA----FNPNARDMAGQASRLRKKVANGAMFAQ 497 Query: 182 TQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFD 240 TQ +D + + + +A + +IPGI+P+ + + A ++ + IP + Sbjct: 498 TQPIYDAGLFFQALEL--TADCAIPLIPGIMPLVSQRNADYLHNEVPGISIPETVLARMC 555 Query: 241 GLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMSYAICHTL 290 GL+ E G IA + + S ++ + E++ + + Sbjct: 556 GLEK--EAGVAEGLAIAREFI-DASFHSSGGYYLMPPFGKVELALDLIEYI 603 >UniRef50_B7RVE0 Methylenetetrahydrofolate reductase n=1 Tax=marine gamma proteobacterium HTCC2148 RepID=B7RVE0_9GAMM Length = 293 Score = 202 bits (514), Expect = 1e-50, Method: Composition-based stats. Identities = 60/295 (20%), Positives = 108/295 (36%), Gaps = 35/295 (11%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G V+ E PP+ +++ + L + +VT S + + Sbjct: 10 AGHFVVTGELTPPKGTDISG--LKARAELLADHIDAFNVTDSHASKMSLSPMAAAHEL-T 66 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS------ 133 G+E +T D L++ W G++++V + GD P PE Sbjct: 67 VLGVEPILQMTIRDRNRIALQSDMLGAWLLGVKNLVCMGGDPPHLGDHPEAKPVFDISTE 126 Query: 134 DLVT--------------LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANR 179 DL+ LL F I +P A+ ++ L+ KV AGA Sbjct: 127 DLIQAAGNLNNGKDMMDNLLSGSTGFHIGAVV----NPGAEDLDKEIARLESKVAAGAKF 182 Query: 180 AITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNVRIPAWMAQM 238 TQ FD + + F +R + +D+ I+ GI+P+ + K A + + +P + Sbjct: 183 FQTQAIFDADRFAGFMERV--SHLDIAILAGIMPIKSVKMAAFMNEKIPGIDVPDHVIDR 240 Query: 239 FDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVR 293 DG D + +A +++K + + + H L E + GV Sbjct: 241 IDGAADTVKE----STAVAAEIIKEI-KPICQGIHVMALGWEEHIPGVLQLAGVT 290 >UniRef50_Q12UZ6 Methylenetetrahydrofolate reductase n=4 Tax=Methanosarcinaceae RepID=Q12UZ6_METBU Length = 294 Score = 201 bits (512), Expect = 2e-50, Method: Composition-based stats. Identities = 61/299 (20%), Positives = 112/299 (37%), Gaps = 26/299 (8%) Query: 10 DALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDR 69 N L + V+ E PP+ +++ TL ++ L +++T + R Sbjct: 3 STFNDVL--NSDRFIVTAEVAPPKGTDISATLEDA--ELIRGLVDAINITDNQRAVMRMS 58 Query: 70 THSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK-- 127 ++ K + G E LTC D L++ GI ++ + GD Sbjct: 59 PIAVGKLLM-DAGHEVIVQLTCRDRNRLALQSDILAASALGIENLCVMTGDYTTKGDHVG 117 Query: 128 -PEMYASDLVTLLKEVADFDIS-------VAAYPEVHPEAKS-----AQADLLNLKRKVD 174 +Y D V LL + +A P A S + +L LK+K++ Sbjct: 118 AKAVYDLDSVQLLSLITKMMGGSDMAGNELAGAPSFTVGAVSNTDVTKRMQMLKLKKKIN 177 Query: 175 AGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPA 233 AGA TQ +DVES+ F D G +V ++ GI+P+ + A ++ +R+ Sbjct: 178 AGARFIQTQAVYDVESFKDFSDLMGQIGPNVLVLAGIIPLRSAAMAHFMNNNIPGIRVGD 237 Query: 234 WMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 + + + D + G IA + + L + H + + + G+ Sbjct: 238 ELIKRMENAKDPIQE----GLEIAAESILELRDL-CRGIHLMPIGGHGNTQRLLEMAGL 291 >UniRef50_B0VZI6 Methylenetetrahydrofolate reductase n=2 Tax=Culicini RepID=B0VZI6_CULQU Length = 443 Score = 201 bits (511), Expect = 3e-50, Method: Composition-based stats. Identities = 71/300 (23%), Positives = 128/300 (42%), Gaps = 27/300 (9%) Query: 4 FHASQRDALNQSLAE---VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY 60 H+ + + + + ++ S E P + + RL+ P F S+ + Sbjct: 154 MHSHENSRNLKQVIQRWTTSERLCYSIELIP------REDFHLDLGRLA---PVFCSLPW 204 Query: 61 GANSGER----DRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVA 116 +++ + T + K A PHL+C + T ++ + G ++ Sbjct: 205 ISDNNLQYQRFADTPMLKMTAKIVPHCSAVPHLSCYNITETQVDKFV----DMGNWNLFV 260 Query: 117 LRGDLPPGSGKPEMYASDLVTLLK--EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVD 174 +RGD G+ ++ DLV L+ D I V YP HPE+ S D+ LK+KVD Sbjct: 261 IRGDTVS-EGQRFQHSCDLVEYLRAKNNPDLTIGVGGYPYGHPESPSVDYDVKYLKQKVD 319 Query: 175 AGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAW 234 G + +TQ +D S+L + D C AGI V I+PG+ + Q + +T V PA Sbjct: 320 LGVDFIVTQTLYDAASFLAYVDECRRAGITVPIVPGLFLPGSPDQLETVLALTRVNPPAG 379 Query: 235 MAQMFDGLDDD-AETRKLVGANIAMDMVKILSRE---GVKDFHFYTLNRAEMSYAICHTL 290 + ++ D + + ++++ L RE V+ HF+T NR ++ + + Sbjct: 380 VRELLQSHAHDEPDQFEAFVVKHFAELIRTLRRERPDEVRLVHFFTFNRLDLLKKVLDAI 439 >UniRef50_C4Z117 Methylenetetrahydrofolate reductase n=1 Tax=Eubacterium eligens ATCC 27750 RepID=C4Z117_EUBE2 Length = 595 Score = 200 bits (510), Expect = 4e-50, Method: Composition-based stats. Identities = 54/278 (19%), Positives = 111/278 (39%), Gaps = 16/278 (5%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 G+ ++ E PP + + + ++ + ++ + R + + + + Sbjct: 318 GRKLIAVELAPPLGIDD-EKIMDAAFLMKESGVDVLTFPDSPSGRTRADSILMAEKVSRE 376 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG---SGKPEMYASDLVT 137 TG+ PH+ C D +R+ N I + + + GD P + ++ D V Sbjct: 377 TGMCVMPHICCRDKNAIAMRSQLLGAHINDINNFLVITGDPIPSVVRASVKSVFNFDSVG 436 Query: 138 LLKEVADFDIS-VAAYP-----EVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESY 191 L+ ++D + A P ++ + + +L +K+K++AGA +TQ F E Sbjct: 437 LMNIISDMNQEQFAGKPVIYGGAINQGRVNFKVELERVKKKMEAGATFFMTQPVFSDEDI 496 Query: 192 LRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDDDAETRK 250 R R G I+ GI+P + + A +MT + + + + D E + Sbjct: 497 DRLRQIKEQTG--ARILCGIMPFVSLRNATFMKNEMTGINVTDEILSRYR-ADMSKEEGE 553 Query: 251 LVGANIAMDMVKILSREGVKDFHF-YTLNRAEMSYAIC 287 G IA +++ + V ++F + NR M I Sbjct: 554 ETGIQIAREIIAKTTDF-VDGYYFSFPFNRVHMLKKII 590 >UniRef50_B9XKW8 Methylenetetrahydrofolate reductase n=1 Tax=bacterium Ellin514 RepID=B9XKW8_9BACT Length = 624 Score = 200 bits (508), Expect = 6e-50, Method: Composition-based stats. Identities = 57/294 (19%), Positives = 111/294 (37%), Gaps = 24/294 (8%) Query: 11 ALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRT 70 L + + + E PP++ L L FV++ + + R Sbjct: 313 RTKSLLELSREKPIIVTELDPPKSL-SLDKLLEGAQALKQAGTDFVTLADNSLAILRVSN 371 Query: 71 HSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE- 129 + +K++TG E HL C D L++ GI H++AL GD E Sbjct: 372 MAAGFLVKEKTGAEPLIHLACRDKNLIGLQSELMGLHALGIDHVLALTGDPAKVGDHQEA 431 Query: 130 --MYASDLVTLLKEVADFDISVAAYP-------------EVHPEAKSAQADLLNLKRKVD 174 +Y + V L++ + + AA +P A++ + + L+ K++ Sbjct: 432 TSVYDVNSVGLIRMIKRLNEGFAANGRDLKTKTQFVIGCAFNPNARNLDSQVRKLEDKLE 491 Query: 175 AGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPA 233 AGA +TQ FD L + G+ V ++ G++P+ N + A+ ++ + IP Sbjct: 492 AGAQFVMTQPIFDP--VLAKVTHEKTKGLGVPVLVGVMPLLNSRNAEFLHNEVPGIIIPE 549 Query: 234 WMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAI 286 G + G I+ ++ + + T L R +++ + Sbjct: 550 MTRDRLRGKEG--AQANAEGLAISRELCDAVLDC-FNGIYLITPLMRYDLTVEL 600 >UniRef50_B8FFJ4 Methylenetetrahydrofolate reductase n=4 Tax=Bacteria RepID=B8FFJ4_DESAA Length = 295 Score = 198 bits (505), Expect = 1e-49, Method: Composition-based stats. Identities = 60/306 (19%), Positives = 113/306 (36%), Gaps = 35/306 (11%) Query: 10 DALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDR 69 Q+L QG+ V+ E PP+ +E+ + L K ++VT +S R Sbjct: 3 SKFKQALD--QGKFVVTSEVAPPKGVNLEKMAHHI--ELLKDKVDAMNVTDHQSSVMRFP 58 Query: 70 THSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK-- 127 + + G E +TC D L+ GI +++ L GD Sbjct: 59 SLG-AALMVKEMGGEPILQMTCRDRNRLALQADLLFAHQRGINNVLCLTGDSVVLGDHKT 117 Query: 128 ----PEMYASDLVTLLKEVAD--------------FDISVAAYPEVHPEAKSAQADLLNL 169 ++ +S LV ++++ F PE +P Q L+ Sbjct: 118 AKGVFDLDSSQLVAAVRKLEKGKDMAGNDLDGAVSFCAGAIVTPEANP----IQPQLIKF 173 Query: 170 KRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD-MTN 228 ++K++AGA TQ +D+E++ F + V+++ GI+ +++ A+ + Sbjct: 174 EKKIEAGAEFIQTQAVYDLENFKNFMEYARQ--FPVKVLAGIILLTSAPMARFMNKNVAG 231 Query: 229 VRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGV-KDFHFYTLNRAEMSYAIC 287 V +P +K G IA +K + E + H + + E+ I Sbjct: 232 VTVPQVFIDEMASAPKGGAIKK--GIEIAGRQIKQIVEENICDGVHIMAIGKEELVPDIM 289 Query: 288 HTLGVR 293 G+ Sbjct: 290 AAGGLL 295 >UniRef50_A8SCX4 Methylenetetrahydrofolate reductase n=3 Tax=Clostridiales RepID=A8SCX4_9FIRM Length = 605 Score = 198 bits (505), Expect = 1e-49, Method: Composition-based stats. Identities = 54/295 (18%), Positives = 121/295 (41%), Gaps = 18/295 (6%) Query: 8 QRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGER 67 DA + L GQ ++ E P+ +++ L + RL + +++ + R Sbjct: 311 TDDAFLRKLR--AGQRVIAVELDSPKDADLTAYLEGA-RRLQAAGADLLTIADCPIARAR 367 Query: 68 DRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK 127 + + + G+ PH+TC D + + + + G+R ++A+ GD P + + Sbjct: 368 MDSSLVACRVHRELGMNVLPHMTCRDRNLNATKALLLGLYAEGVREVLAITGDPIPTAER 427 Query: 128 PEMY----------ASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGA 177 E+ A +V+L E + + + ++ A++ + +L K++ G Sbjct: 428 DEVKNVYQFNSRKLAQYIVSLAGEGREMPSPITVFGALNLNARNFEVELRRAAEKLENGM 487 Query: 178 NRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMA 236 + +TQ ++ + + G +I+ GILPV + + A ++ + + + Sbjct: 488 SGFLTQPVLSAQAVENLKKTRETLGERAKILAGILPVVSQRNAIFMENEVNGIHVDDAII 547 Query: 237 QMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTL 290 Q F+GL D + +G +++ + V F+ T NR + + L Sbjct: 548 QRFEGL--DRAAGEELGLEVSV-QAAKAAAPYVDGFYLMTPFNRVALMERLIARL 599 >UniRef50_A6W6I5 Methylenetetrahydrofolate reductase n=1 Tax=Kineococcus radiotolerans SRS30216 RepID=A6W6I5_KINRD Length = 317 Score = 198 bits (504), Expect = 2e-49, Method: Composition-based stats. Identities = 82/295 (27%), Positives = 136/295 (46%), Gaps = 30/295 (10%) Query: 11 ALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRT 70 L +A G+ +SFE FPPR+ + LW + L + +P FVSVT+GA R + Sbjct: 2 TLAPLVAGAAGRPVLSFELFPPRSESAREGLWRKLSDLLAARPDFVSVTFGAAGATRGPS 61 Query: 71 HSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM 130 ++ + T + A HLTC+ ++ E+ +A ++ + G+R+++ALRGD P G Sbjct: 62 RDLLAHVLRTTAVPAMAHLTCVGSSRREVVDLASEFLDAGVRNVLALRGDPPAGDAGWTP 121 Query: 131 Y------ASDLVTLLK----------------EVADFDISVAAYPEVHPEAKSAQADLLN 168 + A DLV LL+ + ++VAA+P + +L Sbjct: 122 HPDGVATARDLVELLQVADRRRAALRGARVPVDEGPLSLAVAAFPRGG------EGELAA 175 Query: 169 LKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTN 228 L+ K DAGA+ A+ Q F Y F R +AG+ + ++PG+ ++ + ++T Sbjct: 176 LRAKQDAGADFAVCQVTFSAGEYAAFVRRARAAGVRIPLLPGVAVTDCTRRLGRIGELTG 235 Query: 229 VRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMS 283 V +P + D DDA R+ + + L G H YT N AE + Sbjct: 236 VPVPVPLLAALD--TDDAPRRRRAATAFTAGLARGLLDAGAPGVHLYTFNAAEPA 288 >UniRef50_B0PF81 Methylenetetrahydrofolate reductase n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PF81_9FIRM Length = 582 Score = 197 bits (502), Expect = 3e-49, Method: Composition-based stats. Identities = 56/284 (19%), Positives = 107/284 (37%), Gaps = 24/284 (8%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + ++ E PP + L + L + ++VT S R + I+ Sbjct: 303 RKEIAVELDPPFDHDCSFVL-AAASELRACGVDLITVTDSPLSRTRADSLMTAAKIRREA 361 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP------PGSGKPEMYASDL 135 G+E PH++C D LR GI ++ + GD P G + + DL Sbjct: 362 GIEVMPHISCRDKNHIALRAGLLGAAFEGIGRVLIVTGDPPMQAGTRGSDGVYHLSSYDL 421 Query: 136 VTLLKEVA-------DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDV 188 + + + F I A ++ A + A+L K+K+ GA+ TQ F Sbjct: 422 IAWIHSMNSEVFADAPFLIGGA----LNVNAANFDAELARAKKKLSLGASMLFTQPIFSD 477 Query: 189 ESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKK-FADMTNVRIPAWMAQMFDGLDDDAE 247 ++ F R D + GILPV+ +K A +++ + IP + + +G D Sbjct: 478 KAVDHFL-RARQELKDCRLFAGILPVAGYKNALFLINEVSGIEIPDNVVRSLEGKTPDEA 536 Query: 248 TRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTL 290 + + +++ + F+ T L + + + + Sbjct: 537 A--AISVAYSAGIMRRVYDA-ADGFYIMTPLKKVNIVRGLIEEI 577 >UniRef50_Q8DUN2 Methylenetetrahydrofolate reductase n=12 Tax=Streptococcus RepID=Q8DUN2_STRMU Length = 618 Score = 197 bits (502), Expect = 4e-49, Method: Composition-based stats. Identities = 52/308 (16%), Positives = 113/308 (36%), Gaps = 30/308 (9%) Query: 10 DALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDR 69 + + +V+ I + E PP+T + + L +++ + + R Sbjct: 312 EKKESLVDKVKKGITIIAEIDPPKTL-AVDKFVDGVKALDEKGIAAITLADNSLARTRIC 370 Query: 70 THSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP- 128 S+ +KD HL+C D L++ G HI+A+ GD P Sbjct: 371 NLSMASMLKDEIATPFLLHLSCRDHNMIGLQSRLLGMDLLGFDHILAITGDPSKIGDFPG 430 Query: 129 -----EMYASDLVTLLKEVA--------------DFDISVAAYPEVHPEAKSAQADLLNL 169 + + L++L+K++ F ++ A +P K+ + Sbjct: 431 ATSVYDATSFKLLSLIKQLNQGHGYSGASLKKATHFTVAAA----FNPNVKNLSRTGRLI 486 Query: 170 KRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTN 228 ++KV AGA+ ITQ F + V+ + GI+P++++ A ++ Sbjct: 487 EKKVAAGADYFITQPVFSETVIQELSE--VTKPYEQPFFVGIMPITSYNNAVFLHNEVPG 544 Query: 229 VRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAIC 287 + + + + DD ET + V + ++ + + T R +++ + Sbjct: 545 ISLSESFLAKLEAVKDDKETCQKVALAESKKLIDAILAH-FNGIYLITPFLRYDLTVELI 603 Query: 288 HTLGVRPG 295 + V+ Sbjct: 604 DYIQVKTA 611 >UniRef50_A9QPD6 Methylenetetrahydrofolate reductase n=1 Tax=Methylacidiphilum infernorum V4 RepID=A9QPD6_METI4 Length = 617 Score = 196 bits (499), Expect = 7e-49, Method: Composition-based stats. Identities = 55/287 (19%), Positives = 108/287 (37%), Gaps = 24/287 (8%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + E+ P+T M + L + + +++ + + R + ++ + Sbjct: 331 KPVFMVEYDSPKTLSMGKFLEG-VKAIEKAGADALTLADNSLAILRVSNFAAAIHVRRVS 389 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP---EMYASDLVTL 138 L H+ C D L++ G RHI+AL GD P +Y + V L Sbjct: 390 KLIPVLHVACRDRNLLGLQSELMGLGTLGFRHILALTGDPAKSGDHPGATSVYDLNSVGL 449 Query: 139 LKEVADFDISVAAYP-------------EVHPEAKSAQADLLNLKRKVDAGANRAITQFF 185 ++ +A + V A +P A + L+ K+ AGA +TQ Sbjct: 450 IRLLAGLNRGVNAAGKDLKGKTDFIIGCAFNPNTVQFDAQVRKLEAKLAAGARFVMTQPV 509 Query: 186 FDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDD 244 FD E + + G V + GI+P+ N++ A+ ++ + IP + L+ Sbjct: 510 FDFELIKKIFNYLKPLG--VPVFVGIMPILNYRNAEFLHNEVPGISIPEKIRSRMKDLEG 567 Query: 245 DAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTL 290 E G A ++ + + + + T R ++S + +L Sbjct: 568 --EKATEAGVEFARELGEEILSH-FRAIYLITPFLRYDISVRLLESL 611 >UniRef50_D0P2W8 Methylenetetrahydrofolate reductase n=1 Tax=Phytophthora infestans T30-4 RepID=D0P2W8_PHYIN Length = 244 Score = 196 bits (499), Expect = 7e-49, Method: Composition-based stats. Identities = 73/272 (26%), Positives = 115/272 (42%), Gaps = 52/272 (19%) Query: 1 MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRL-SSLKPKFVSVT 59 M S R A + + VSFEFFP +T+ L ++ + +L+P FV++T Sbjct: 1 MGKIIESIRSAYATRTDDTSARPTVSFEFFPAKTNAGVFNLLTRVEEMGLALQPTFVTLT 60 Query: 60 YGANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRG 119 + + + I I++ L+ HLTC ++L+ I ++ GIR+I+ALRG Sbjct: 61 WRSAFKDEALWLRIGAHIQNEFQLDVLLHLTC-HLPTEQLKRILKNARAAGIRNILALRG 119 Query: 120 DLPPGSGKPE------MYASDLVTLLKEVAD--FDISVAAYPEVH----------PEAKS 161 D P G+ + A DL+ L++E F I+ A Y EVH P ++ Sbjct: 120 DPPIGAEQWSPVEGGLSNAVDLIKLIREEHGDYFCIACAGYAEVHTESWNHPDLPPSNEA 179 Query: 162 AQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAK 221 DL LK K DAGA+ ITQFFFDV++ + + Sbjct: 180 RALDLQRLKAKQDAGADFIITQFFFDVDNMIHW--------------------------- 212 Query: 222 KFADMTNVRIPAWMAQMFDGLDDDAETRKLVG 253 R+P + D + +D + G Sbjct: 213 -----CKTRVPEKVLAALDAIKNDDAAVRRYG 239 >UniRef50_C4GEB4 Methylenetetrahydrofolate reductase n=1 Tax=Shuttleworthia satelles DSM 14600 RepID=C4GEB4_9FIRM Length = 670 Score = 195 bits (495), Expect = 2e-48, Method: Composition-based stats. Identities = 53/304 (17%), Positives = 130/304 (42%), Gaps = 21/304 (6%) Query: 2 SFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYG 61 + +DA Q L + G+ V+ E PR ++ + + + L +++ Sbjct: 370 GLSVSKDQDAFYQKL--MSGRKVVAVELDSPRGCDITR-FMEAAENLKEAGADIITIADN 426 Query: 62 ANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL 121 + R + + I+ + GL+A PH+TC D + +++ + GIR+++ + GD Sbjct: 427 PIAKARMDSSIVAGIIRRQVGLDALPHMTCRDRNLNATKSLLLGNYAQGIRNVLVITGDP 486 Query: 122 PPGSGKPEM------YASDLVTLLK----EVADFDISVAAYPEVHPEAKSAQADLLNLKR 171 P + + E+ + L+ +K E F + + ++ A++ + +L + Sbjct: 487 IPSARRDEVKVVYQFNSRKLMAYMKALGQEEGTFPSPMHIFGALNVNARNFEIELDRARE 546 Query: 172 KVDAGANRAITQFFFDVESYLRFR---DRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMT 227 KV AGA +TQ E+ + + + ++ GI+PV + + + ++++ Sbjct: 547 KVQAGAVGFLTQPALTTEAIANICRASETLRAENSRIRLLGGIIPVISERNGRFMQSEIS 606 Query: 228 NVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAI 286 + +P + + + + D + + + ++++ K + + V ++ T R + I Sbjct: 607 GIDVPDALIERY--VGKDRADCEEIAVDSSLELAKTM-EDAVDGYYLVTPFMRDYLIRRI 663 Query: 287 CHTL 290 L Sbjct: 664 MERL 667 >UniRef50_A6UAD8 Methylenetetrahydrofolate reductase n=11 Tax=Proteobacteria RepID=A6UAD8_SINMW Length = 367 Score = 194 bits (494), Expect = 3e-48, Method: Composition-based stats. Identities = 57/310 (18%), Positives = 117/310 (37%), Gaps = 30/310 (9%) Query: 7 SQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE 66 S R L + L +G+ V+ E PP ++ + + ++ + + Sbjct: 21 SSRGRLERVLR--RGEFAVTAELNPPDSANPHDVYERAA--IFDGWVDGINAVDASGANC 76 Query: 67 RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG 126 + I + R G + C D ++ G+++I+ L GD Sbjct: 77 HMSSVGICA-LLTRMGYAPIMQIACRDRNRIAIQGDVLGASAMGVQNIMCLTGDGVQAGD 135 Query: 127 KPEMYAS---------DLVTLLKEVADFDIS--------VAAYPEVHPEAKSAQADLLNL 169 +P + V ++++ + F V ++P A L Sbjct: 136 QPGAKPVFDLDCMSLLETVRIMRDNSKFLSGRKLSTPPHVFLGAAINPFAPPYDFRPYRL 195 Query: 170 KRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVE--IIPGILPVSNFKQAKKF-ADM 226 +K++AGA +Q+ FDV + + + G+ + I+ G+ P+++ K A+ +++ Sbjct: 196 AKKIEAGAQFVQSQYCFDVPMFREYMKKVRDLGLHEKCFILVGVGPLASAKTARWIRSNV 255 Query: 227 TNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSR-EGVKDFHFYTLNRAEMSYA 285 + IP + + +G D +K G + +D++ + EGV H + E Sbjct: 256 PGIHIPDGIIRRLEGAQD----QKKEGKQLCIDVMNEVKEIEGVSGVHVMAYRQEEYVAE 311 Query: 286 ICHTLGVRPG 295 I H GV G Sbjct: 312 IVHESGVLRG 321 >UniRef50_Q189R6 Methylenetetrahydrofolate reductase n=6 Tax=Clostridium RepID=Q189R6_CLOD6 Length = 293 Score = 194 bits (494), Expect = 3e-48, Method: Composition-based stats. Identities = 61/295 (20%), Positives = 117/295 (39%), Gaps = 33/295 (11%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G+ V+ E PP+ +++ + + + + +VT ++ R + + K +K Sbjct: 10 SGKFAVTTEMAPPKGTDLSHLIECAKPLV--GRVHAANVTDFQSAVMRATSLATCKLLK- 66 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASDLV 136 GLE +T D ++ GI +++AL GD P+ ++ D V Sbjct: 67 DAGLEPVIQITGRDRNRIAIQGEMLSAGVFGINNLLALTGDHTSVGDHPQAKGVFDLDSV 126 Query: 137 TLLKE-----------------VADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANR 179 +L+ DF + + PE P + LL +K+K+ AGA Sbjct: 127 GILQTAETLMAGTDMAGNKLKGSPDFYLGASVTPEYSP----IEVQLLKMKKKIKAGAKF 182 Query: 180 AITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQM 238 TQ +D+ + +FR+ +D +++ GI+P+ + AK A++ + +P + Sbjct: 183 FQTQALYDINTMRKFRELTRD--MDCKVLAGIVPLKSPGMAKFMTANVPGIFVPDEQIER 240 Query: 239 FDGLDDDAETRKLVGANIAMDMVKILSREG-VKDFHFYTLNRAEMSYAICHTLGV 292 E G +A +++K L E H + E AI G+ Sbjct: 241 LRAAGK--ENWVSEGIKMAGELIKQLKEEDLCDGVHIMAIGAEENIPAILDAAGL 293 >UniRef50_A7S5W8 Methylenetetrahydrofolate reductase n=1 Tax=Nematostella vectensis RepID=A7S5W8_NEMVE Length = 619 Score = 193 bits (491), Expect = 5e-48, Method: Composition-based stats. Identities = 82/310 (26%), Positives = 132/310 (42%), Gaps = 25/310 (8%) Query: 8 QRDALNQSLAEVQGQ-----INVSFEFFPPRTSEMEQTLWNSIDRLSSL---KPKFVSVT 59 A ++ L +++ + S E FPP+T +L+ + RL+ L KP F +T Sbjct: 9 SNSATSELLRKIKEKIDNHERFFSVEIFPPKTFNGATSLFGIMCRLNELEDTKPLFADIT 68 Query: 60 YGANSGE------RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRH 113 + + T I + H+ T ++ G+ Sbjct: 69 WKPSKEPMSDKCLEPTTLLIAASARQVNNFNTIIHIPYFGTTRTQVFEHLMRAKEFGVCG 128 Query: 114 IVALR---GDLPPGSGKPEMYAS--DLVTLLKEVA--DFDISVAAYPEVHPEAKSAQADL 166 I A R G + ++S DL+ +K+ DF I+V YP +DL Sbjct: 129 IRAQRPAPGITYENPVHEDGFSSIEDLIIFIKQEFGNDFAIAVTGYP--SQRCDWYDSDL 186 Query: 167 LNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADM 226 LKR+VDAGA+ TQ FF+VE++ +F C + GID+ IIPGILP+ N + + M Sbjct: 187 ALLKREVDAGADFITTQLFFEVETFFKFERDCRNIGIDIPIIPGILPIQNLQTVRNLRKM 246 Query: 227 T-NVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREG-VKDFHFYTLNRAEMSY 284 V++P + ++ +D E + G A M + L G V+ H YTLN + Sbjct: 247 NFAVKVPNEILEVLKSGKEDLEAIQAFGIQHATKMCQELFASGKVQGIHLYTLNIEKPVM 306 Query: 285 AICHTLGVRP 294 +I L + Sbjct: 307 SILENLKISK 316 >UniRef50_C5RGW2 Methylenetetrahydrofolate reductase n=1 Tax=Clostridium cellulovorans 743B RepID=C5RGW2_CLOCL Length = 609 Score = 193 bits (490), Expect = 7e-48, Method: Composition-based stats. Identities = 45/282 (15%), Positives = 112/282 (39%), Gaps = 16/282 (5%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 +G+ ++ E PP +E + RL +++ + R + + +K Sbjct: 327 RGEKIIAVELDPPINTE-IDFFISGAKRLKGQGIDAITIADCPIARARVDSSLLACKLKR 385 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEM------YAS 133 + A PH+TC D + + + GI +++ + GD P + + E+ +S Sbjct: 386 ELDITAIPHMTCRDRNINATKALLLGLNVEGINNVLVVTGDPIPSADREEIKGVFSFNSS 445 Query: 134 DLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESY 191 L + ++E+ + F ++ ++ +L ++K+D G +TQ E+ Sbjct: 446 ILSSYIRELNETTFSSPFNVCGALNLNVRNFSNELEKAQKKIDNGITMFLTQPVLTEEAM 505 Query: 192 LRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDDDAETRK 250 + ++ +I+ GI+PV +++ A +++ + + + + + + E Sbjct: 506 ENL--KLARKKLNAKILGGIIPVVSYRNACFMNNEISGINVSEEIIERYKDVSK--EEAT 561 Query: 251 LVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTLG 291 + I+ + + V F+ T R ++ I + Sbjct: 562 RLAVEISTGIATEM-SSYVDGFYIITPFKRIDIVSEIVSNIK 602 >UniRef50_A3EWD2 Methylenetetrahydrofolate reductase n=2 Tax=Leptospirillum sp. Group II RepID=A3EWD2_9BACT Length = 289 Score = 193 bits (490), Expect = 7e-48, Method: Composition-based stats. Identities = 56/294 (19%), Positives = 100/294 (34%), Gaps = 38/294 (12%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLK--PKFVSVTYGANSGERDRTHSIIKGI 77 + V+ E PP+ + + +DRL+ LK ++VT R ++ + Sbjct: 9 AREFLVTAECSPPKGT----RIDGLLDRLTPLKNRIHGINVTDNQTGVMRMCPMAMGLHL 64 Query: 78 KDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS---- 133 K GL+ +T D +++ + G+ ++ L GD P PE Sbjct: 65 KG-IGLDPIIQITLRDRNRLAIQSDLLGMSSLGLSQVLCLTGDPPKLGDHPEAKPVFDIP 123 Query: 134 --DLVTLL--------------KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGA 177 +L+ + D A PE + + + K DAGA Sbjct: 124 TQELIRAITLLNGGTDLSGKDLNGKTDILPGAACSPEG-----DQETEFRKFEEKFDAGA 178 Query: 178 NRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNVRIPAWMA 236 TQ F E F ++ V +I GI+ + + K A+ + + +P + Sbjct: 179 RFFQTQAVFSPEKMEEFMRF--ASPFSVPVIAGIILLKSAKMARYLNDHVPGITVPPPLI 236 Query: 237 QMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + D G IA + ++ + R V H T+ E I Sbjct: 237 ERLDKC--PPGQALESGIAIAAETIRAI-RPLVHGVHIMTVGAEETIPRILDQA 287 >UniRef50_B9JGE7 Methylenetetrahydrofolate reductase n=3 Tax=Rhizobiales RepID=B9JGE7_AGRRK Length = 368 Score = 192 bits (489), Expect = 1e-47, Method: Composition-based stats. Identities = 58/310 (18%), Positives = 118/310 (38%), Gaps = 30/310 (9%) Query: 7 SQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE 66 S L + L +G+ V+ E PP ++ E ++ S ++ + + Sbjct: 22 SSLGRLERVLR--RGEFAVTAELNPPDSANPED-VYERAAIFSGW-VDGINAVDASGANC 77 Query: 67 RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG 126 + I + R G + C D ++ G+ +I+ L GD Sbjct: 78 HMSSVGICA-LLTRMGYAPIMQIACRDKNRIAIQGDVLGAAAMGVCNIMCLTGDGVQAGD 136 Query: 127 KPEMYAS---------DLVTLLKEVADFDIS--------VAAYPEVHPEAKSAQADLLNL 169 +P + V ++++ A F V ++P A L Sbjct: 137 QPGAKPVFDLDCMSLLETVRVMRDNAKFLSGRKLTSPPKVFLGAAINPFAPPYDFRPYRL 196 Query: 170 KRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVE--IIPGILPVSNFKQAKKF-ADM 226 +K++AGA +Q+ +DV + + + G+ + I+ G+ P+++ K A+ +++ Sbjct: 197 AKKIEAGAQFVQSQYCYDVPMFRDYMKKVRDLGLHEKCFILVGVGPLASAKTARWMRSNV 256 Query: 227 TNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSR-EGVKDFHFYTLNRAEMSYA 285 V IP + + +G +D +K G + +D++ + EGV H + E Sbjct: 257 PGVHIPDEIIKRIEGAED----QKKEGKQLCIDIINEVKEIEGVSGVHVMAYRQEEYVAE 312 Query: 286 ICHTLGVRPG 295 + H GV G Sbjct: 313 MVHDSGVLKG 322 >UniRef50_C8WWX3 Methylenetetrahydrofolate reductase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WWX3_ALIAD Length = 637 Score = 192 bits (488), Expect = 1e-47, Method: Composition-based stats. Identities = 53/291 (18%), Positives = 111/291 (38%), Gaps = 27/291 (9%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 + + + E PP+ + L+ +++ + R ++ +K Sbjct: 340 AREKKAIVVELDPPKHL-SIARFLEGAEALAGAGADLITMADNSLGSVRVSNMALASLLK 398 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL------PPGSGKPEMYA 132 R G+E H+TC D ++ GIR+++ + GD P + ++ + Sbjct: 399 QR-GIEPLVHVTCRDRNLIGQQSHLMGLAVLGIRNVLLVTGDPSRYGELPGATSVYDVSS 457 Query: 133 SDLVTLLKEVADFDISVAAYP-----------EVHPEAKSAQADLLNLKRKVDAGANRAI 181 DL +++ + + I + P +P + + + L+RKV+AGA+ + Sbjct: 458 MDLTKMVRRL-NEGIGFSGQPLKQPSRFVIGTAFNPHVHNFRKAVERLRRKVEAGADFVM 516 Query: 182 TQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFD 240 TQ FD + G V + GI+P+++ + A+ + +R+ + Sbjct: 517 TQPVFDPNLMAAIAEATRDLG--VPVFVGIMPLTSARNAEFLHHQVPGIRLSEQALRRMQ 574 Query: 241 GLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTL 290 E VG IA ++V++ R + T R EM+ + Sbjct: 575 EAA--PEEAPAVGEAIARELVEVAIRL-FPGIYLVTPFLRYEMTVRLTEYA 622 >UniRef50_B1GYU6 Methylenetetrahydrofolate reductase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=B1GYU6_UNCTG Length = 287 Score = 192 bits (488), Expect = 2e-47, Method: Composition-based stats. Identities = 62/300 (20%), Positives = 105/300 (35%), Gaps = 37/300 (12%) Query: 9 RDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERD 68 R + L + ++ E FPP+ + + D L L V+VT + R Sbjct: 2 RLKFKEKLK--SDKFLITAELFPPKGVD-ISSFLRRADCLYGL--DAVNVTDNQRASMRV 56 Query: 69 RTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP 128 + ++ I +E LT D L++ GI +++ L GD P Sbjct: 57 SSLAM-SRILIERAIEPILQLTARDRNRISLQSELLGANVLGIENVLLLSGDHPSIGECS 115 Query: 129 E---MYASDLVTLLKE-----------------VADFDISVAAYPEVHPEAKSAQADLLN 168 + +Y D + L+K F + +P +S L Sbjct: 116 DAKAVYDLDTIQLIKTARLLETGVDIAGKKLQGSPKFCVGAVV----NPSVQSVDLQALM 171 Query: 169 LKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTN 228 L++KV AG TQ FDV+ Y F D+ + V+I+PG++ + + K + M+ Sbjct: 172 LEKKVKAGTEFFQTQAIFDVQIYKNFFDKVK--HLKVKILPGMILIKSPKFLQFLKSMSG 229 Query: 229 VRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICH 288 V IP + + D I +K L R H + E + Sbjct: 230 VNIPDEIKDRINSASDPLAE----SIKICSATIKEL-RSFADGVHIMAIGTEEHIPEMIR 284 >UniRef50_A8SPV0 Methylenetetrahydrofolate reductase n=2 Tax=Clostridiales RepID=A8SPV0_9FIRM Length = 606 Score = 192 bits (487), Expect = 2e-47, Method: Composition-based stats. Identities = 56/285 (19%), Positives = 109/285 (38%), Gaps = 16/285 (5%) Query: 15 SLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSII 74 ++ G ++ E PP Q L ++ L V+ + R + + Sbjct: 327 AVKNAGGHKLIAVELAPPVDVND-QKLLDAAHILKQSHVDVVTFPDSPSGRTRADSILMA 385 Query: 75 KGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP------GSGKP 128 + + TGL PHL C D +R NGI+ + + GD P Sbjct: 386 EKVHKETGLRVMPHLCCRDKNAIAIRGSVLGAQLNGIKDFLVITGDPVPVMFRQTTRSVF 445 Query: 129 EMYASDLVTLLKEVADF-DIS--VAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFF 185 + ++ LL+ + + I + ++ + + ++ +KRK++AGA ++Q Sbjct: 446 NFDSVGMMKLLQTMNEEVFIGDKITYGGAINQNRINTKFEIDRIKRKLEAGAEFFLSQPV 505 Query: 186 FDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDD 244 F E RD G I+ GI+P+ + + A +MT + IP + + + Sbjct: 506 FSREQAQILRDMKAETGAT--ILVGIMPLVSRRNALFMKNEMTGIEIPDEIIERYGENAT 563 Query: 245 DAETRKLVGANIAMDMVKILSREGVKDFHF-YTLNRAEMSYAICH 288 + + G IA + + + + ++F + NR M I Sbjct: 564 -RQEGEDCGIQIARE-ILDYTADFADGYYFSFPFNRVHMLAHIVD 606 >UniRef50_C7LX76 Methylenetetrahydrofolate reductase n=1 Tax=Desulfomicrobium baculatum DSM 4028 RepID=C7LX76_DESBD Length = 599 Score = 192 bits (487), Expect = 2e-47, Method: Composition-based stats. Identities = 50/308 (16%), Positives = 117/308 (37%), Gaps = 34/308 (11%) Query: 7 SQRDALNQSLAEVQGQ-INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG 65 + A L+ G+ + E PP+ + + + + + LS+ +++ + Sbjct: 302 KTQTAAPTRLSRRLGEGKVILVELDPPKHLD-VEPVLAAAEALSAAGVDAITIAENPLAV 360 Query: 66 ERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS 125 R + ++ RTG++ H+T D +++ + + +++A+ GD P Sbjct: 361 PRLSNIVLAGMVRARTGVDVVVHMTGRDRNLVGMQSTIMGLAASKLHNVLAVTGDPPSAG 420 Query: 126 ------GKPEMYASDLVTLL--------------KEVADFDISVAAYPEVHPEAKSAQAD 165 G ++ + +L+ LL + +F I A +P ++ Sbjct: 421 SAERVSGVYDLRSLELMELLAGFNQGRNHYGDSMRLPVNFCIGGA----FNPNTRNMALQ 476 Query: 166 LLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-A 224 + +++K+ AGA+ +TQ + I I+ GI+P+++ + A+ Sbjct: 477 VGRMEKKMAAGASYFLTQPVYSRARVDEILAATR--HIKAPIVLGIMPLASSRNAEFLHN 534 Query: 225 DMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMS 283 + + IP + D + G +IA ++++ + NR M+ Sbjct: 535 EFPGIEIPLETRERMARAGDHG---QEEGVDIAWELLEYAWSH-FAGVYIIPPFNRHGMA 590 Query: 284 YAICHTLG 291 + LG Sbjct: 591 LELMRRLG 598 >UniRef50_B7AQD9 Methylenetetrahydrofolate reductase n=1 Tax=Bacteroides pectinophilus ATCC 43243 RepID=B7AQD9_9BACE Length = 603 Score = 191 bits (486), Expect = 2e-47, Method: Composition-based stats. Identities = 59/280 (21%), Positives = 112/280 (40%), Gaps = 20/280 (7%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G V+ E PP ++ L L S+ ++ R + + + Sbjct: 326 SGHKVVAVELDPPYDAK-YDRLIEQAQYLKSIGVDILTFADSPMGRSRVDSVLMSLKVTQ 384 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG------SGKPEMYAS 133 TG+ PH+ C D +R+ + NGIR ++ + GD P +G + + Sbjct: 385 ETGMMVMPHVCCRDKNVIAMRSTLLGAYINGIRQLLLVTGDPVPSVSRVSTTGVFDYNSI 444 Query: 134 DLVTLLKEVADFDISVAAYPEVHPEAKS-----AQADLLNLKRKVDAGANRAITQFFFDV 188 L+ +KE+ A P + A + + +++K+D GA+ +TQ F Sbjct: 445 RLMNFVKEMNQEH--FADEPLYYGGALNVTLGRIDRIMERMQKKIDNGASYFMTQPVFSK 502 Query: 189 ESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDDDAE 247 E R + +D +I+ GI+P+ +++ A + + +P + + D E Sbjct: 503 EGIERL--AIIKEKMDTKILCGIMPLVSYRNANFIKNEFIGIDVPDEIVARYSP-DMSKE 559 Query: 248 TRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMSYAI 286 + VGA IA +++ + V F+F NR + I Sbjct: 560 EGEAVGAQIANELIGQMYDY-VDGFYFMLPFNRVSLMDKI 598 >UniRef50_B9DIA5 Methylenetetrahydrofolate reductase n=10 Tax=Staphylococcus RepID=B9DIA5_STACT Length = 613 Score = 190 bits (482), Expect = 7e-47, Method: Composition-based stats. Identities = 58/304 (19%), Positives = 122/304 (40%), Gaps = 30/304 (9%) Query: 5 HASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANS 64 H S + +V+ V E P+ + + N + +L +++ + + Sbjct: 302 HPSIPVQKDNLTTKVKSGPTVIVELDTPKHLDTTKFFVN-VTKLDKANVDAITLADNSLA 360 Query: 65 GERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL--- 121 R + IK +E H+TC D L++ GI I+A+ GD Sbjct: 361 TVRVSNIAAASIIKQNYNIEPLVHITCRDRNLIGLQSHLLGLSLLGINEILAITGDPSKV 420 Query: 122 ---PPGSGKPEMYASDLVTL--------------LKEVADFDISVAAYPEVHPEAKSAQA 164 P + ++ + L L LK +F+I+ A +P + +A Sbjct: 421 GHLPGANNVYDVNSKGLTELAVRFNQGLNIDGGALKTTTNFNIAGA----FNPNVRKMEA 476 Query: 165 DLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF- 223 + L +K+D+G N ITQ + VE ++ +A +D GI+P+++++ A+ Sbjct: 477 AVRRLDKKLDSGMNYFITQPVYTVEKIQEIAEK--TAHLDSPFFIGIMPITSYRNAQFLH 534 Query: 224 ADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEM 282 ++ + +P + + F+ + DD + K + I +V +++ + T + + Sbjct: 535 NEVPGITLPEDVLEQFEAVKDDKQKTKELSLRICRKLVDEVTKH-FNGLYLITPFEQVDY 593 Query: 283 SYAI 286 S + Sbjct: 594 SLEL 597 >UniRef50_C0EVI7 Methylenetetrahydrofolate reductase n=1 Tax=Eubacterium hallii DSM 3353 RepID=C0EVI7_9FIRM Length = 638 Score = 189 bits (481), Expect = 9e-47, Method: Composition-based stats. Identities = 51/281 (18%), Positives = 107/281 (38%), Gaps = 16/281 (5%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 G++ + E PP ++ + L N L S K +++ + R + IK Sbjct: 363 GELVCAVELDPPFDTDDTK-LLNGAKALLSTKADIITIADSPLARSRADASLMAAKIKMT 421 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK------PEMYASD 134 TG++ PHL+C D +R+ + +GIR+ + + GD + + + Sbjct: 422 TGMDVMPHLSCRDKNRIAIRSGLLGSYASGIRNYLFVTGDPVAREDREFTKSVFDFNSIR 481 Query: 135 LVTLLKEVAD--FDISVAAY-PEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESY 191 L+ + + F Y ++ S + + +K++AG +TQ +D E Sbjct: 482 LMKFAQSMNQEVFKDDTIFYGGALNQNGASPENIAGRMLKKMEAGCRYFLTQPVYDKEGI 541 Query: 192 LRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDDDAETRK 250 R + +I+ GI+P+ + + A +M + +P + + E + Sbjct: 542 ERL--TFLKERTGAKILIGIMPLVSRRNALFIKNEMPGIHVPDEVVAKYKEGASREEFEE 599 Query: 251 LVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTL 290 + + + F+F T NR + +I + Sbjct: 600 AA--IEISKQIIEMGKGIGAGFYFMTPFNRVSLVKSILEYV 638 >UniRef50_C6HTS1 Methylenetetrahydrofolate reductase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HTS1_9BACT Length = 290 Score = 189 bits (480), Expect = 1e-46, Method: Composition-based stats. Identities = 60/299 (20%), Positives = 107/299 (35%), Gaps = 35/299 (11%) Query: 11 ALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRT 70 Q+LA+ ++ E PP+ +E + L + + +++T + R Sbjct: 2 TFRQALADRS-TFIITAECSPPKGTETSELLRKLLP--LKGRIHGMNITDNQTAVMRMSP 58 Query: 71 HSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE- 129 ++ +K GL+ +T D +++ + GI ++ L GD PE Sbjct: 59 FAMGLHLKT-IGLDPIVQITLRDRNRLAIQSDLLGMSSLGIGQVLCLSGDPATIGDHPET 117 Query: 130 --MYASDLVTLLKEV-----------------ADFDISVAAYPEVHPEAKSAQADLLNLK 170 ++ L++ V D A PE + + Sbjct: 118 KPVFDLSSPELIRAVTLLNGGTDLSGADLTGPTDILPGAATSPEG-----DLSVEKKRFE 172 Query: 171 RKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNV 229 K DAGA TQ FD + RF D G V +I GI+ + + A+ + + Sbjct: 173 EKFDAGARFFQTQVVFDADRMDRFMDFARPFG--VPVICGIILLKSPAMARYLNEKVPGI 230 Query: 230 RIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICH 288 R+P + + + E R L G IA + ++ + V H T+ E AI Sbjct: 231 RVPEPLIARLESV--PREERLLEGVRIAAETIRTM-APLVNGVHIMTVGAEEQIPAILD 286 >UniRef50_C0W5C3 Methylenetetrahydrofolate reductase n=1 Tax=Actinomyces urogenitalis DSM 15434 RepID=C0W5C3_9ACTO Length = 384 Score = 188 bits (479), Expect = 1e-46, Method: Composition-based stats. Identities = 72/304 (23%), Positives = 124/304 (40%), Gaps = 38/304 (12%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY------GANSGERDR------ 69 + ++S E FPPR W ++DRL + +P FVSVTY A Sbjct: 44 RPSLSLELFPPRPGRYASQTWGALDRLLAARPDFVSVTYRPRFITTAGGPTAAAGSPTRL 103 Query: 70 --------THSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL 121 + ++ + + + HLTC+ + I R + + G+R +ALRGD Sbjct: 104 HVVREHNPSEDVVAHVIATSRVPLMAHLTCLGYRKANVVEIVRLFLDMGVRRFLALRGDP 163 Query: 122 PPGSGKPEM-----YASDLVTLLKEVADFDISVAAYPEVHPEAK--------SAQADLLN 168 P G ++ +A LV +++EV A H + ++ Sbjct: 164 PRGVAAEDVVGELRHADQLVRVIREVEAEYFDDGA---RHVQVAVAAYPAAVDYAREIGV 220 Query: 169 LKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTN 228 L K AGA+ AITQ F++ E YL G+ + I+PGI+P+++ ++ + D+T Sbjct: 221 LAAKQAAGADLAITQVFYESEDYLALARAASYCGVTMPILPGIIPLTDLRRLTRLEDLTG 280 Query: 229 VRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICH 288 V +P ++Q + G + + + L G H YT NR + + Sbjct: 281 VSVPTRLSQTLTSRQG--ASVMTAGIDATLQLAGDLIEGGAPGLHLYTFNRTRPALDVIS 338 Query: 289 TLGV 292 + Sbjct: 339 QFRL 342 >UniRef50_B3TCN7 Methylenetetrahydrofolate reductase n=1 Tax=uncultured marine bacterium HF4000_APKG2098 RepID=B3TCN7_9BACT Length = 298 Score = 188 bits (478), Expect = 2e-46, Method: Composition-based stats. Identities = 58/304 (19%), Positives = 108/304 (35%), Gaps = 26/304 (8%) Query: 8 QRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGER 67 + L++ L + G + E PP +S +TL I L + ++VT + Sbjct: 3 YQSPLHKKLHD--GVFVFTAETTPPDSSNK-ETLLKKIKSLKDV-ADAINVTDSPGAKVH 58 Query: 68 DRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK 127 I + ++ LT D L+ G+ +I+ L GD P + Sbjct: 59 MSAL-TAAIILAQNDIDPILQLTVRDRNRLALQGDLVGASALGVHNILCLSGDDPKVGDQ 117 Query: 128 PEMYASD------LVT---LLKEVADFDISVAAYPE-----VHPEAKSA-QADLLNLKRK 172 PE + LV ++++ F A P E S + + + K Sbjct: 118 PETKPAQDIDSTTLVATANMMRKDKKFPSGRAIDPAPKLFIGGAEVPSKGKPNTEKILGK 177 Query: 173 VDAGANRAITQFFFDVESYLRFRDRCVSAGI--DVEIIPGILPVSNFKQAKKFA-DMTNV 229 + G + TQ+ F+ + + AGI + G+ P ++ K AK ++ V Sbjct: 178 IKNGIDFFQTQYVFEAKKLEEYMKVLNDAGILEKTSFLIGLGPFASAKSAKWMNDNLFGV 237 Query: 230 RIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHT 289 +P + + + D E K V + + + + GVK H + E+ I Sbjct: 238 DVPDEIIKRLEQAKDQREESKKVCLEL-IQIFHEIK--GVKGIHLMGHKKEEVIAEIIKE 294 Query: 290 LGVR 293 + Sbjct: 295 SKIS 298 >UniRef50_B8CZI6 Methylenetetrahydrofolate reductase n=1 Tax=Halothermothrix orenii H 168 RepID=B8CZI6_HALOH Length = 309 Score = 188 bits (478), Expect = 2e-46, Method: Composition-based stats. Identities = 59/314 (18%), Positives = 113/314 (35%), Gaps = 41/314 (13%) Query: 4 FHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN 63 +R L+ S + + V+ E PPR E + + LS ++ T Sbjct: 1 MSREERVELDFSRVLTEREFIVTAELDPPRGVNTEDVVEK-VKYLSDY-VDAINFTDSPM 58 Query: 64 SGERDRTHSIIKGIKDRTGLEA--APHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL 121 + + ++ +K++ + HLT D L++ G+++ + L GD Sbjct: 59 ARMKMNPVALTHHLKNKFNFKVDFICHLTGRDRNLIGLQSELLGGALLGVKNYLFLTGDK 118 Query: 122 PPGSGKPE---MYASD---LVTLLKEVA--------------DFDISVAAYPEVHPEAKS 161 P P ++ D LV L ++ D I P + Sbjct: 119 PEYGDHPSSTGVFDCDGTALVKLANQLNGGRDYAGNPLNGPLDITIGAGINPGGN----- 173 Query: 162 AQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVS----AGIDVEIIPGILPVSNF 217 ++ LK ++ +GA TQ +D + F +R + + I+ GI+P+ N+ Sbjct: 174 LTVEIEKLKSRIGSGARFIQTQIVYDPGVVINFMERIKTIEALWPVKPRILFGIMPLKNY 233 Query: 218 KQAKKF-ADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT 276 K A ++ V IPA + + D + G +A + V + V H Sbjct: 234 KMATYIHENVPGVDIPAPVMKAIKKGD------ERTGIKLAKEFVLNIKDY-VDGIHIMP 286 Query: 277 LNRAEMSYAICHTL 290 + R E+ + + Sbjct: 287 MGRMEVVSELVDAI 300 >UniRef50_Q39WH6 Methylenetetrahydrofolate reductase n=4 Tax=Geobacter RepID=Q39WH6_GEOMG Length = 299 Score = 188 bits (478), Expect = 2e-46, Method: Composition-based stats. Identities = 63/304 (20%), Positives = 108/304 (35%), Gaps = 33/304 (10%) Query: 4 FHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN 63 ++ R+ L + ++ E PP+ + + L L ++VT Sbjct: 7 MSSTLREKLE------SNRFVITAEVCPPKGCDCGE-FMEKARNLKGL-VDAINVTDNQG 58 Query: 64 SGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP 123 + R + + G+E LTC D L++ G+ +I++L GD Sbjct: 59 ANVRISPLAPAALLTRE-GIEPILQLTCRDRNRMALQSELLAAAALGVTNILSLSGDYIS 117 Query: 124 GSGK---PEMYASDLVTLLKEVADFDIS--VAAYP-EV----------HPEAKSAQADLL 167 ++ D V LL+ +A + + P E PEA L Sbjct: 118 FGDHAGAKPVFDLDSVQLLQTIAALNAGRDFSGAPLEGAPSFFAGAAAAPEADPFDLTLP 177 Query: 168 NLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD-M 226 L +KV AGA TQ F + RF + G V+II GI+ + + A+ + Sbjct: 178 KLAKKVSAGARFFQTQAVFSPDRLARFSEAVRPLG--VKIIAGIILLKSAGMARYITKNI 235 Query: 227 TNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAI 286 +++P + + E VG IA + +R H + R E+ I Sbjct: 236 PGLKVPPEIVAELEAAGRPLE----VGVAIARRLA-TAARPFCDGVHIMAMGREELVPNI 290 Query: 287 CHTL 290 L Sbjct: 291 VAGL 294 >UniRef50_A5N923 Methylenetetrahydrofolate reductase n=2 Tax=Clostridium kluyveri RepID=A5N923_CLOK5 Length = 590 Score = 187 bits (475), Expect = 5e-46, Method: Composition-based stats. Identities = 47/286 (16%), Positives = 113/286 (39%), Gaps = 24/286 (8%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 +G+ ++ E PP +E NS L + +++ + R + + +K Sbjct: 308 KGKKIIAVELDPPIDTE-VDFFLNSARTLKEQEIDAITIADCPIARARVDSSLLACKLKR 366 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS------ 133 + PH+TC D + + + G+ +++ + GD P + + E+ A Sbjct: 367 ELDITTIPHMTCRDRNINATKALLLGLNIEGVNNVLVVTGDPIPSAERDEVKAMFSFNSA 426 Query: 134 DLVTLLKEVAD------FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFD 187 L + + D F+I A ++ +++ +L K K++ G +TQ Sbjct: 427 ILANYITNLNDTIFSSPFNICGA----LNVNSRNFNTELKRAKTKIENGIAVFLTQPILT 482 Query: 188 VESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDDDA 246 E+ + + I+ GI+PV +++ A +++ +R+ + + + + Sbjct: 483 EEALENL--KLARRELTARILGGIIPVVSYRNACFMNNEISGIRVSEEIIKQYKDVSK-- 538 Query: 247 ETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTLG 291 E + I+ D+ + + V ++ T R ++ I + + Sbjct: 539 EEAVKLAVKISTDIAEQIY-PYVDGYYLITPFKRIDIISEIINNIK 583 >UniRef50_B4LC84 Methylenetetrahydrofolate reductase n=3 Tax=Drosophila RepID=B4LC84_DROVI Length = 390 Score = 186 bits (473), Expect = 7e-46, Method: Composition-based stats. Identities = 59/253 (23%), Positives = 106/253 (41%), Gaps = 17/253 (6%) Query: 48 LSSLKPKFVSVTYGA-----NSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTI 102 + P F+S+ + ER T +I+ + T + A PHL+ T + + Sbjct: 127 FLPVLPTFISIVWLPQYWNVMPIERVETLQLIRNL--ETHIPAMPHLSLFRQTKERIDEF 184 Query: 103 ARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVAD--FDISVAAYPEVHPEAK 160 R+++A+RGD + Y+ LV + V I+VA +P+ + Sbjct: 185 L----ALNFRNMLAVRGDKTH-EDQVYRYSHQLVEHARRVRGVNISIAVAGHPQGYAGGP 239 Query: 161 SAQAD-LLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQ 219 A+ + LK+K+D GA+ ITQ + E+ + F +AGI I+ G++ +FK Sbjct: 240 QGLAESIEMLKKKIDNGADFIITQLCYSPETIVEFLRGARNAGIQTPIMVGVVVPDSFKS 299 Query: 220 AKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSRE--GVKDFHFYTL 277 ++ + +PA + +D K +A+ ++ + GV FYTL Sbjct: 300 YALIEMISKISLPAEARAEVEKYQNDDAKVKSYFVQLALRTIQQVLDANLGVHGIQFYTL 359 Query: 278 NRAEMSYAICHTL 290 NR + L Sbjct: 360 NRFGSVQDVLCEL 372 >UniRef50_A9BD12 Methylenetetrahydrofolate reductase n=2 Tax=Prochlorococcus marinus RepID=A9BD12_PROM4 Length = 309 Score = 186 bits (472), Expect = 1e-45, Method: Composition-based stats. Identities = 57/290 (19%), Positives = 102/290 (35%), Gaps = 29/290 (10%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 ++ E PPR + + +LS + ++VT G+ + R + ++ K + L Sbjct: 27 AITAEIMPPRGGDPSHAI-AMASKLSD-RVHALNVTDGSRAIMRMSSLAVCKLLL-EANL 83 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP---EMYASDLVTLLK 140 E + C D L+ GI++++ L GD +P ++ + V LLK Sbjct: 84 EPVLQIACRDKNRIGLQAEILGAHALGIKNVLCLTGDPVKAGDQPNARPVHDFESVQLLK 143 Query: 141 EVADFDIS---------------VAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFF 185 +VA + A P K+ + L L+RK AGA TQ Sbjct: 144 QVAALNRGEDPVQGQLPNGRTALFAG-AAADPNCKNLNSLLKRLERKKLAGAQFLQTQMV 202 Query: 186 FDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD-MTNVRIPAWMAQMFDGLDD 244 + RF ++ ++ G+ + + K A + IP + D + Sbjct: 203 MNSRVLERFSKEIAD-PLEFPVLAGVFLLKSAKNAAFINKVVPGACIPNSILARLDNAHE 261 Query: 245 DAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRP 294 + G IA + VK K H + + I V+ Sbjct: 262 PIKE----GITIAAEQVKSFLGIT-KGVHIMAIRAEHLIPQILDQANVKK 306 >UniRef50_Q1NSQ8 Methylenetetrahydrofolate reductase n=3 Tax=Deltaproteobacteria RepID=Q1NSQ8_9DELT Length = 704 Score = 185 bits (469), Expect = 2e-45, Method: Composition-based stats. Identities = 60/291 (20%), Positives = 116/291 (39%), Gaps = 31/291 (10%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 ++ + E PP +M L + L++ +S+ + R ++ I+ Sbjct: 402 QPDRMPILVELDPPTHLDMGGVLEGA-KALAAGGTDAISLGESPLAVLRTENLALAHRIQ 460 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL------PPGSGKPEMYA 132 G++ HLTC D L++ GI I+A+ GD P SG ++ + Sbjct: 461 QEAGIKTIIHLTCRDRNALGLQSHIMGAHLLGIDSILAVTGDPATSSDQPGVSGVFDVRS 520 Query: 133 SDLVTL--------------LKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGAN 178 LV + +KE DF + VA + Q + L+RK GA Sbjct: 521 FGLVRMIDRFNQGFNMAGKNIKEKTDFSLGVA----FSYRPSNPQVQIKRLERKAALGAR 576 Query: 179 RAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQ 237 +TQ FF + ++ ++ +D+ I PGI P+ + + A ++ + IPA + Q Sbjct: 577 YVMTQPFFAADEVEAMMEK--TSHLDLLIFPGIFPLISARNADFLHNEVPGISIPATLRQ 634 Query: 238 MFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMSYAIC 287 + E ++ V + ++V+ + + LN+ E++ + Sbjct: 635 KLHQYE-QVEDQRRVAMDFTRELVEKI-SSFSDGLYLISPLNKWEVANDLV 683 >UniRef50_Q1AXR8 Methylenetetrahydrofolate reductase n=2 Tax=Bacteria RepID=Q1AXR8_RUBXD Length = 611 Score = 184 bits (467), Expect = 4e-45, Method: Composition-based stats. Identities = 66/304 (21%), Positives = 128/304 (42%), Gaps = 34/304 (11%) Query: 9 RDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERD 68 R L L G V+ E PR +++ + + RL + ++ GA + R Sbjct: 319 RSRLAGKLHG--GGFAVAVEVDLPRGNDLSGVVE-AARRLKERGADAIDISDGARARLRM 375 Query: 69 RTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL------P 122 + + +++R G+EA H++C D L+ G+R+I+A+ GD P Sbjct: 376 HPVAAARIVQERAGIEAVAHMSCRDRNILGLQADLLAAAALGVRNILAVTGDPAQIGDYP 435 Query: 123 PGSGKPEMYASDLVTLLKEV--------------ADFDISVAAYPEVHPEAKSAQADLLN 168 +G + A LV +L + F I A +P A+ A++ Sbjct: 436 EATGVFDTDAVGLVHILSRMNRGEDLAGNAIGRPPGFLIGAA----FNPTAEDLDAEVER 491 Query: 169 LKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMT 227 L+RK++AGA+ TQ F++ + R +R G ++ G++P+ + +QA+ ++ Sbjct: 492 LRRKLEAGAHAFWTQPVFELPALERALERLE--GTGARLLLGLMPLRSARQAEFLHHEVP 549 Query: 228 NVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMSYAI 286 V+IPA + + L G +A +++ +R V + + E++ + Sbjct: 550 GVKIPAEVRRKLAELSPQDAP--RYGVEVAGNLLAR-ARPLVSGAYIMPPASAPELAAEV 606 Query: 287 CHTL 290 L Sbjct: 607 MEAL 610 >UniRef50_Q7M8S8 Methylenetetrahydrofolate reductase n=1 Tax=Wolinella succinogenes RepID=Q7M8S8_WOLSU Length = 318 Score = 183 bits (466), Expect = 4e-45, Method: Composition-based stats. Identities = 48/304 (15%), Positives = 106/304 (34%), Gaps = 26/304 (8%) Query: 8 QRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGER 67 + + + ++Q ++ E P + + + + + T + R Sbjct: 12 TKTMIETLIHKLQKDHFLTLEVAPHASPTLTPLIHSIQSVGLEKRVDGFVCTDSPLAKLR 71 Query: 68 DRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL------ 121 + ++ L+ D L+ +R I+AL GD Sbjct: 72 HSSILATIKLQQSLQKPVICTLSMRDRNSLALQGELMGANEFDVRAILALTGDAIRLGDQ 131 Query: 122 PPGSGKPEMYASDLVTLLKEVADFDISVAAYPEVHP------------EAKSAQADLLNL 169 P G E ++ L+ +++ + I + P P ++S ++ L Sbjct: 132 PQAKGVFEGKSTLLLEIIQSF-NRGIDLQGQPLKSPLRPLYPLAVINSYSQSPESLKKRL 190 Query: 170 KRKVDAGANRAITQFFFDVESYLRFR----DRCVSAGIDVEIIPGILPVSNFKQAKKF-A 224 ++K++AGA +TQ +D+E + G E++ G PV +++ A + Sbjct: 191 RQKIEAGAIGIVTQPIYDLEVAKTLLGWVHEINQELGTFSELVLGYFPVVSYRTAHFLYS 250 Query: 225 DMTNVRIPAWMAQMFDGLDD-DAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMS 283 + V IP + + E + VG ++ ++ L HF + N +++ Sbjct: 251 KLPGVYIPNEWLSQLEAASKINPEEERRVGLELSRNIWLGLWDFH-PKIHFMSANNTKLA 309 Query: 284 YAIC 287 I Sbjct: 310 SEIL 313 >UniRef50_B8I637 Methylenetetrahydrofolate reductase n=2 Tax=Clostridium RepID=B8I637_CLOCE Length = 615 Score = 183 bits (465), Expect = 6e-45, Method: Composition-based stats. Identities = 52/286 (18%), Positives = 107/286 (37%), Gaps = 21/286 (7%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 V+ + + E PP + E L +++ L +++ + R + + I+ Sbjct: 336 VKTKKPILVEVDPPFDTNWEYMLRDTL-LLKQAGADIITIADSPLAKARAESTIMAAKIQ 394 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG------SGKPEMYA 132 + PH+TC D ++ GIR+++ + GD G + Sbjct: 395 REAVIPVMPHITCRDKNLLGIKASLLGVHIEGIRNVLVITGDPIANIERSRIKGVFSFNS 454 Query: 133 SDLVTLLKEVAD--FD---ISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFD 187 S+L +K + F I +A ++ A + A+L K++ G + +TQ + Sbjct: 455 SNLANYIKSLNSNVFCGQEIKIAG--ALNVNAVNFSAELKKAFTKIENGISCLLTQAIYT 512 Query: 188 VESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDDDA 246 + + + V I G +P+ +K A ++ + I + F D Sbjct: 513 KSAVDNLLKAVET--LKVPIFAGFMPIVGYKNALFIDNEVPGIDIDNETIEKFR--DKSR 568 Query: 247 ETRKLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTLG 291 E + +G I MD++K + V + T L R + + + Sbjct: 569 EESEKLGMEITMDILKEIYPH-VSGIYLMTPLKRTNVICELIKKIK 613 >UniRef50_Q2LZ54 Methylenetetrahydrofolate reductase n=1 Tax=Drosophila pseudoobscura pseudoobscura RepID=Q2LZ54_DROPS Length = 433 Score = 182 bits (463), Expect = 1e-44, Method: Composition-based stats. Identities = 53/255 (20%), Positives = 101/255 (39%), Gaps = 16/255 (6%) Query: 47 RLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD----RTGLEAAPHLTCIDATPDELRTI 102 + P F+S+ + + ++ ++ + PHL+ T + L Sbjct: 172 EFLPVLPTFLSIVWLGATYCSVDPIELVTSLQLARSLEARIPVMPHLSLYCLTEERLNEF 231 Query: 103 ARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVAD--FDISVAAYPEVH---P 157 +++ +RGD G+ Y +V ++ I VA YPE + Sbjct: 232 L----ALNFTNVLPIRGDAVK-EGQTFRYTQQVVEHIRRQRGDRISICVAGYPEGYTNLA 286 Query: 158 EAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNF 217 E + + LK K+ AGA+ ITQ + ++ ++F SAGI V I+ G L +F Sbjct: 287 EPQDPAEAMRYLKAKIAAGADCIITQMCYRSDTIIQFIKDVRSAGITVPIVVGQLVADSF 346 Query: 218 KQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSRE--GVKDFHFY 275 + ++ V +P + ++ DAE +++ +++ + GV FY Sbjct: 347 RTYCLSENIAGVHLPPGLRSELLAIESDAERVSQFFIQLSIRIIRDILAADVGVYGVQFY 406 Query: 276 TLNRAEMSYAICHTL 290 T N+ A+ L Sbjct: 407 TFNQFAPVQAVLKEL 421 >UniRef50_B9L912 Methylenetetrahydrofolate reductase n=1 Tax=Nautilia profundicola AmH RepID=B9L912_NAUPA Length = 298 Score = 177 bits (450), Expect = 3e-43, Method: Composition-based stats. Identities = 49/297 (16%), Positives = 104/297 (35%), Gaps = 27/297 (9%) Query: 15 SLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSII 74 L E ++ E PP+ ++ + + S T S + + Sbjct: 1 MLKEKLKDKYITLETTPPKLPTVDLMIEKIEKSEAYKYIDGFSTTDCPLSKLKYNSIIAA 60 Query: 75 KGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------ 128 ++++ ++ D L++ + G+ HI+AL GD S +P Sbjct: 61 YKLQEKFKKPVIATMSMRDRNKIALQSDLLGANDLGVTHILALTGDPANMSDQPKAKAVV 120 Query: 129 EMYASDLVTLLKEVAD--------FDI---SVAAYPEVHPEAKSAQADLLNLKRKVDAGA 177 E + L+ +++ + F I + + + AK+ + + +KV A Sbjct: 121 EGSSILLLEIIRAFNNGMDYAGKEFKIKPKPITPFAVSNSYAKNFSSIERRIFKKVQNYA 180 Query: 178 NRAITQFFFDVESYLRFRD-------RCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNV 229 ITQ +D+ + + + EII G P++ K A+ A + + Sbjct: 181 VGIITQPVYDINIVEKLLEIKEKVISEFNDERKEAEIILGFFPITKLKTAQFLHAHVPGI 240 Query: 230 RIPAWMAQMF-DGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYA 285 +P + + VG ++ ++ + L ++ H T NR E+ Sbjct: 241 YVPEEWIEKLIKAHKISEDEEYKVGMELSRNLFQQLLKKH-PKIHIMTANRFEIVKE 296 >UniRef50_A6Q7Z1 Methylenetetrahydrofolate reductase n=4 Tax=Epsilonproteobacteria RepID=A6Q7Z1_SULNB Length = 305 Score = 176 bits (446), Expect = 1e-42, Method: Composition-based stats. Identities = 48/294 (16%), Positives = 103/294 (35%), Gaps = 28/294 (9%) Query: 21 GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDR 80 + ++ E PP + +++ L + K S T + + ++ Sbjct: 12 DKNFITVEVNPPHGASLDKILEDIKKYKLHEKVTGFSCTDNPLAKLKMSGVLSAIRLQQT 71 Query: 81 TGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS---DLVT 137 ++ D L++ + +R I+AL GD S +PE+ D Sbjct: 72 FKKPVIATMSMRDKNKLSLQSTLLGANDFDLRCILALTGDPAKFSDQPEVKGVLERDSTL 131 Query: 138 LLKEVADFDISV------------AAYPE--VHPEAKSAQADLLNLKRKVDAGANRAITQ 183 LL + + V YP + A++ ++ + +K+D GA ITQ Sbjct: 132 LLSIIYHLNNGVDYSNKPLNPAPKPIYPFAVSNSYARNMRSLQKRIVKKLDYGARAIITQ 191 Query: 184 FFFDVESYLRFRDR--------CVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAW 234 +D+E+ + + + +I G P+ + A + + +P Sbjct: 192 PVYDLENAMELLELFEEAKTMSVRETSKEAHLILGQFPIVRARTANFIDDKVPGISVPKD 251 Query: 235 MAQMFD-GLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAIC 287 + + D E + VG ++ + + ++ K H T NR ++ + Sbjct: 252 IIDEMNLAAMDGEEKEQEVGFTLSKKIFDEMMKKHGK-VHMMTHNRFDLCSELI 304 >UniRef50_UPI0001BCEC92 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein n=1 Tax=Selenomonas noxia ATCC 43541 RepID=UPI0001BCEC92 Length = 597 Score = 174 bits (441), Expect = 3e-42, Method: Composition-based stats. Identities = 49/285 (17%), Positives = 110/285 (38%), Gaps = 17/285 (5%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G ++ E PP T ++ L + L + +++ + R + + Sbjct: 315 SGGKPIAVELDPPETGNADKFLVG-VRELQAAGISAITIADNPIARARMDAAMLAGRVHR 373 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS------ 133 G+E PH+TC D + +++I G+ +++A+ GD P + + E+ + Sbjct: 374 ELGIEPIPHMTCRDRNLNAIKSILLGLSAEGVHNMIAITGDPIPTAERDEVKSVYQFNSR 433 Query: 134 ---DLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES 190 VT L D + + ++ AK + L ++K++AG TQ E Sbjct: 434 KLASFVTSLGSRGDI-VPFHVFGALNVNAKHFPSQLGLARKKMEAGMTGFFTQPVLS-ER 491 Query: 191 YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQMFDGLDDDAETR 249 I+ GI+PV + + A+ +++ + + + + GL D Sbjct: 492 AKENLQTARDMLPGAFILGGIMPVVSERNARFMESEIVGIHVEERIISAYRGL--DRTAA 549 Query: 250 KLVGANIAMDMVKILSREGVKDFHFYT-LNRAEMSYAICHTLGVR 293 + + +++ + K + + ++ T +R + I + R Sbjct: 550 EELAVRLSLAIAKDI-EPYIDGYYIITPFSRTALIARIVEGIKER 593 >UniRef50_A6DEC7 Methylenetetrahydrofolate reductase n=1 Tax=Caminibacter mediatlanticus TB-2 RepID=A6DEC7_9PROT Length = 296 Score = 174 bits (441), Expect = 4e-42, Method: Composition-based stats. Identities = 46/297 (15%), Positives = 104/297 (35%), Gaps = 26/297 (8%) Query: 16 LAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIK 75 + ++ ++ E PP+ +E + + S T S + + Sbjct: 1 MIDINKDRLITLETTPPKLPTIEPMIEKIKKSEAYKYIDGFSTTDCPLSKLKYNSIIAAY 60 Query: 76 GIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------E 129 ++ +T D L++ + + +I+A+ GD S +P E Sbjct: 61 KLQKNFKKPVIATITMRDRNKIALQSDLLGANDLDVTNILAITGDPASMSDQPNTKAVVE 120 Query: 130 MYASDLVTLLKEVAD--------FDI---SVAAYPEVHPEAKSAQADLLNLKRKVDAGAN 178 ++ L+ +++ + F I + + + AK+ + + +KV A Sbjct: 121 GNSTLLLDIIRAFNNGMDYSGKEFKIKPKPITPFAVSNSFAKNFSSIEKKMYKKVKHYAK 180 Query: 179 RAITQFFFDVESYLRF---RDRCVSAGIDVE---IIPGILPVSNFKQAKKF-ADMTNVRI 231 ITQ FD + + RD+ + +I G P++ K A+ + + + + Sbjct: 181 GIITQPVFDEDIAYKLISIRDKIRFEFKETREFDLIFGFFPITKLKTAQFLKSHVPGIYV 240 Query: 232 PAWMAQMF-DGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAIC 287 P + + VG +++ + + L + H T NR E+ + Sbjct: 241 PDEWIEKLIKAHKISEDEEYKVGLDLSKTLFEKLQKIH-PKIHIMTANRFEIVKELF 296 >UniRef50_C3XLP8 Methylenetetrahydrofolate reductase n=1 Tax=Helicobacter winghamensis ATCC BAA-430 RepID=C3XLP8_9HELI Length = 307 Score = 172 bits (436), Expect = 1e-41, Method: Composition-based stats. Identities = 51/313 (16%), Positives = 116/313 (37%), Gaps = 32/313 (10%) Query: 1 MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDR---LSSLKPKFVS 57 M F +++ ++ L +G+ ++EF P + + L+ + L L Sbjct: 1 MPGFESNKIESFIDKL--QKGKKCYTYEFSAPAS-FCLEKLFCGLKNQSFLQEL--DAFI 55 Query: 58 VTYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVAL 117 T + +++ + + ++ D L++ + +R ++AL Sbjct: 56 CTDSPLGKLKHSPILASLKLQNTFKIPSIATISMRDKNTLALQSELIGMNSLDLRLVLAL 115 Query: 118 RGDL------PPGSGKPEMYASDLVTLL------KEVADFD---ISVAAYPEV--HPEAK 160 GD P G E ++ L+ ++ K++ + I YP + AK Sbjct: 116 TGDPLRLGNQPQAKGVFEGNSALLLKIIDALNLNKDINGENLQGIPKRIYPFCVLNSYAK 175 Query: 161 SAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGI----DVEIIPGILPVSN 216 + ++ ++ K+ GA TQ +D C + + + ++ G P+++ Sbjct: 176 NKESLYKKMREKIRNGALAIFTQPIYDESIAKELLKWCDAINLEFRTNCALVFGFFPIAS 235 Query: 217 FKQAKKFA-DMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY 275 +K A + V + + + + + VG + ++ K LS + FHF Sbjct: 236 YKTALFLHYKLPGVFVSQEWLKALEIAKKNGKEA-EVGLQKSKELFKALSAL-QQKFHFM 293 Query: 276 TLNRAEMSYAICH 288 + N+ E+ I Sbjct: 294 SANKPEIIAQILK 306 >UniRef50_B2K1S3 Methylenetetrahydrofolate reductase n=22 Tax=Yersinia RepID=B2K1S3_YERPB Length = 266 Score = 172 bits (436), Expect = 2e-41, Method: Composition-based stats. Identities = 55/272 (20%), Positives = 112/272 (41%), Gaps = 12/272 (4%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + +SFE + + + ++ I+ +L P + +V S T+ + ++++T Sbjct: 2 ERKLSFEMNSAKNEKEMENIFKLIEFTDTLDPIYYTVNTEIGSSVWSDTYRTVIELREKT 61 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP-GSGKPEMYASDLVTLLK 140 + PH+T + E+ I Y N GI +RGD P Y +L+ L++ Sbjct: 62 DVSLIPHITINNKKEREIMQIIEKYINVGICEFFVIRGDKHVYDQDNPINYGVELIELIR 121 Query: 141 EVAD-FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES---YLRFRD 196 I + YP+ H E + ++ +RK G N I+Q + + + D Sbjct: 122 RSHKHIGIKTSLYPDFHKETTEVKEEIDWNERKYQLGVNEFISQLTLNTNALDFLSHWVD 181 Query: 197 RCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANI 256 + P I+P+ NF +KF ++ P W+ + + + E ++ +G I Sbjct: 182 KER------PFTPSIMPLGNFSFIEKFTSSNSIDYPLWIKKFANSKSNSNEDKENIGIEI 235 Query: 257 AMDMVKILSREGVKDFHFYTLNRAEMSYAICH 288 + + + + H +TLN+ ++ I Sbjct: 236 IRFLCREYLNQRER-LHVFTLNKVDVMKKIFQ 266 >UniRef50_B2Q6I6 Methylenetetrahydrofolate reductase n=1 Tax=Providencia stuartii ATCC 25827 RepID=B2Q6I6_PROST Length = 273 Score = 169 bits (428), Expect = 1e-40, Method: Composition-based stats. Identities = 58/271 (21%), Positives = 113/271 (41%), Gaps = 10/271 (3%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + +SFE S+++ TL + + L P F +V E T++ +K+ T Sbjct: 10 ETALSFEIS--AMSKIDNTLEHLLKNTEELTPLFYTVNTEIGKTEWRDTYNTCCELKNLT 67 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPP-GSGKPEMYASDLVTLLK 140 + PH+ + EL I +Y N I + +RGD P Y +L+ ++ Sbjct: 68 HVNVVPHIAINNKDECELCFIIEEYLKNDITELFVIRGDRHRFDEELPFNYGIELIDFIR 127 Query: 141 EVADF-DISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199 I + YP+ H E+ + + ++ L++K+ G I+Q + ++ + + Sbjct: 128 RRYPEVMIKSSIYPDYHKESITPEIEIDWLRKKLQLGVTELISQLCLNKNAFSYMKKQL- 186 Query: 200 SAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMD 259 G D+ I ++P+ NF + F + P W+ + + + G + Sbjct: 187 --GNDIPITISMMPMLNFSFIESFFKNNAIDYPLWIKKHIRP--SNINNHRAFGIQLTQF 242 Query: 260 MVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 ++ +E + HF+TLN AEM + L Sbjct: 243 LIGEYIKENKR-LHFFTLNNAEMVKKLFDKL 272 >UniRef50_Q9VTI0 Methylenetetrahydrofolate reductase n=6 Tax=melanogaster group RepID=Q9VTI0_DROME Length = 349 Score = 168 bits (427), Expect = 2e-40, Method: Composition-based stats. Identities = 55/265 (20%), Positives = 106/265 (40%), Gaps = 29/265 (10%) Query: 48 LSSLKPKFVSVTYGAN------SGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRT 101 L P FVS + + + + + + + T + PH++ + L Sbjct: 74 FLPLLPTFVSFVWLSQRYWDVEPVGQVESLQMAQHLA--TRIPVLPHVSAYRMSRQRLDQ 131 Query: 102 IARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTL-LKEVAD-FDISVAAYPEVHPEA 159 ++A+RGD + + +V +++ + + V YPE + Sbjct: 132 FL----ALNFSSLLAVRGDRVH-EDQDFSISYPMVEQSIRQRGETISVCVGGYPEGYTSL 186 Query: 160 KSA----QADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVS 215 ++ LK K+DAGA+ ITQ + E ++F C +AGI V I+ G++ Sbjct: 187 GDIPQNSAKNMEFLKAKIDAGADCIITQLCYRPEVIVQFVKDCRAAGISVPIVVGLMSHE 246 Query: 216 NFKQAKKFADMTNVRIPAWMAQMFDGL--------DDDAETRKLVGANIAMDMVKILSRE 267 +F+ +T V +P + + D L D + + ++ + ++ + Sbjct: 247 SFRSYSMIEQITGVHLPDDLREQLDQLHSAHMKDMKSDQDLIRRFFVSLTVRTIRNVLDA 306 Query: 268 --GVKDFHFYTLNRAEMSYAICHTL 290 GV FHF+TLNR + A+ L Sbjct: 307 DVGVWGFHFFTLNRFKSVQAVLQEL 331 >UniRef50_B8FJ30 Methylenetetrahydrofolate reductase n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FJ30_DESAA Length = 312 Score = 166 bits (421), Expect = 7e-40, Method: Composition-based stats. Identities = 61/294 (20%), Positives = 111/294 (37%), Gaps = 31/294 (10%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 GQ V E PP+ ++ N+I + V ++ R + I Sbjct: 9 AGQFIVLAEMEPPKGVDVTDFTANAIR--VKDQVDAFVVPEMNSAVMRMSSLG-ASLILQ 65 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPE---MYASDLV 136 GL + C D L+ G+R+++A+ G+ P + +Y DL+ Sbjct: 66 SKGLPTVMQVNCRDRNRLGLQADLLAAGAIGVRNVMAVTGEDPSFGDHHQASAVYDIDLI 125 Query: 137 TLLKEVADFD-------ISVAAYPEVH--------PEAKSAQADLLNLKRKVDAGANRAI 181 LLK V + +A P + K+ Q ++ +KRK+DAGA I Sbjct: 126 ELLKAVRGMTEGKDMAGVDLAGAPSFYCGSTVNAGVRGKALQLEIDEMKRKMDAGARFFI 185 Query: 182 TQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMT-NVRIPAWMAQMFD 240 T F++ F ++ A +V+++P +L + + A+ + +V + + + Sbjct: 186 TPPVFNMNDLSDFMEKASRA--EVKVLPTVLLLKSVGMARYIDRHSDHVSVGDALIKRIM 243 Query: 241 GLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRP 294 D A A IA D ++ G+ TL M + L ++P Sbjct: 244 SASDKAREC----AQIAADTIQAAKNAGLDGVMIATLGWEHMLPQV---LNLKP 290 >UniRef50_B4MKM9 Methylenetetrahydrofolate reductase n=1 Tax=Drosophila willistoni RepID=B4MKM9_DROWI Length = 318 Score = 165 bits (417), Expect = 2e-39, Method: Composition-based stats. Identities = 49/255 (19%), Positives = 100/255 (39%), Gaps = 22/255 (8%) Query: 47 RLSSLKPKFVSVTYGANSG-----ERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRT 101 P FVS+ + S + + + + K + + + HL+ T + L Sbjct: 68 EFLPTLPAFVSLVWLGISYWNIPMDENYSLQLAKHM--ESHIPVLAHLSAYRMTEERLNE 125 Query: 102 IARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKE--VADFDISVAAYPEV-HPE 158 R+++ +RGD G+ Y +++ ++ + I V YPE H Sbjct: 126 FL----AKNFRNVLIVRGDEIH-EGQKFTYGREMIEYARQQRKDNLSIGVPGYPEGYHKN 180 Query: 159 -AKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNF 217 ++ LK K+ AG ITQ + + ++F + C A + V II GI+ + Sbjct: 181 PINDPILNIQYLKEKISAGGEFIITQTCYSSQKIIQFINDCREANVTVPIIIGIMVPDSV 240 Query: 218 KQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSRE--GVKDFHFY 275 + ++T R+P + L +A+ ++ + ++ + G++ F+ Sbjct: 241 RNYHIVKNITGARLPNEVND----LSVNADDILKFFVDLTVRNIRDIFTANLGIQGIQFF 296 Query: 276 TLNRAEMSYAICHTL 290 T+NR + L Sbjct: 297 TMNRFRPVQMVLDEL 311 >UniRef50_C0QIT4 Methylenetetrahydrofolate reductase n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QIT4_DESAH Length = 274 Score = 164 bits (415), Expect = 4e-39, Method: Composition-based stats. Identities = 60/283 (21%), Positives = 104/283 (36%), Gaps = 17/283 (6%) Query: 12 LNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTH 71 + + + ++ E PP + E L + +S L SV + Sbjct: 1 MEKRFMTAKDGFKITVEVVPPAGFDPEPLLEQLVS-ISGLGFDGFSVATNPVAKPCMCAM 59 Query: 72 SIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY 131 ++ I+ RTG + H T D L+ GI ++A GD+ + Sbjct: 60 AMCSLIQGRTGKPSILHCTTRDHNRLSLQGQLWGAKALGIDTVLAATGDMVAKKERKITS 119 Query: 132 AS-DL----VTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFF 186 DL + + + D V + HPE + L++KVDAGA +TQ + Sbjct: 120 TVSDLNVFQLAAMAVQSGMDTGVVF--DSHPEINGFDLAVDRLRKKVDAGAGFVVTQPVY 177 Query: 187 DVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNVRIPAWMAQMFDGLDDD 245 D S R + G+ + +I GILP+ K A + + +P + +D Sbjct: 178 DRASAERI--AVATQGLGIPVILGILPLRTLKHAVFLHDRVAGIAVPESVRSAMALAEDT 235 Query: 246 AETRKLVGANIAMDMVKILSREGVKDFHFY-TLNRAEMSYAIC 287 GA+ A M+ ++RE N E+ ++I Sbjct: 236 VAE----GASNASKML-TIARESFAGACVMPPFNHYEVLHSII 273 >UniRef50_B5YA71 Methylenetetrahydrofolate reductase n=2 Tax=Dictyoglomus RepID=B5YA71_DICT6 Length = 288 Score = 163 bits (413), Expect = 6e-39, Method: Composition-based stats. Identities = 56/295 (18%), Positives = 101/295 (34%), Gaps = 37/295 (12%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 G+ ++ E PPR ++ + ++ L + V+VT N G R + + + Sbjct: 9 SGKFVITAEVSPPRGVDVSSFIEKTL--LLKDRVDAVNVTDFQNVGVRITSL-VGSYLLL 65 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS---GKPEMYASDLV 136 R G+E +T D + + GIR+++ L GD ++ D Sbjct: 66 REGMEPIFQITARDRNRVAISGELLSAYTLGIRNVLVLTGDYTTTGIAKSAKPVFDLDAT 125 Query: 137 TL-----------------LKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANR 179 + L + DF + P + P L AGA Sbjct: 126 NILVVAKRLEDGEDFSGKKLNKNPDFFLGAVFNPNLVPLEIEILKLLKK----KKAGAEF 181 Query: 180 AITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKK-FADMTNVRIPAWMAQM 238 TQ FFD+ R R+R G +++II G+ + + + + + ++IP + M Sbjct: 182 FQTQLFFDLSVMERVRERV---GNEIKIIAGVTIFKSIEMLEYMMSSVPGIKIPTEILDM 238 Query: 239 FDGLDDDAETRKLVGANIAMDMVKILSRE-GVKDFHFYTLNRAEMSYAICHTLGV 292 F D K + + L + HF +R + L Sbjct: 239 FRNTKD----IKSLSIEFCAEFCSKLKESKLLDGIHFLA-SRPSDIIKVLDLLNW 288 >UniRef50_C0QE80 Methylenetetrahydrofolate reductase n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QE80_DESAH Length = 505 Score = 163 bits (413), Expect = 7e-39, Method: Composition-based stats. Identities = 50/291 (17%), Positives = 96/291 (32%), Gaps = 25/291 (8%) Query: 21 GQINVSFEFFPPRTSEM--EQTLWNSI-DRLSSLKPKFVSVTYGANSGERDRTHSIIKGI 77 ++ E P R S TL D S + VS+T + I Sbjct: 13 DNFVITIELVPGRESFGRNTDTLIGIAKDAFSDGRVSAVSITDNPGGNPSLSPDVLGYEI 72 Query: 78 KDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP------PGSGKPEMY 131 R GL+ H TC D + + A G+++I+ L GD G+ ++ Sbjct: 73 -FRHGLDVIVHFTCRDMNRVGMESRALQLARMGMKNILCLTGDYSGKGFGGRGAPVFDLD 131 Query: 132 ASDLVTLLKEVAD----------FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAI 181 + L ++K +++ F P +++ A L K+DAGA+ AI Sbjct: 132 SVLLTRMVKGLSNRMMTSGDPDPFFSGCGVSPFKTLKSECL-AQYKKLDMKIDAGASFAI 190 Query: 182 TQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD--MTNVRIPAWMAQMF 239 TQ +D+ + + ++ + + + K A+ + + + + Sbjct: 191 TQLGYDINKFNELIRYHNEKNAHIPVMASVF-LLSPKAARAMNKHRVPGAHVSDALYEKV 249 Query: 240 DGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNR-AEMSYAICHT 289 + + + IL G + H ++R I Sbjct: 250 TQEWKIPKEGLNAAIERSARLGAILKGIGFRGIHIGGVHRSFTTVARILDR 300 >UniRef50_C8R0R0 Methylenetetrahydrofolate reductase n=1 Tax=Desulfurivibrio alkaliphilus AHT2 RepID=C8R0R0_9DELT Length = 513 Score = 161 bits (407), Expect = 4e-38, Method: Composition-based stats. Identities = 52/296 (17%), Positives = 99/296 (33%), Gaps = 34/296 (11%) Query: 10 DALNQSLAEVQGQINVSFEFFPPRTSEM---EQTLWNSIDRLSSLKPKFVSVTYGANSGE 66 ++L++ ++ E P R+ ++ L + ++ + VS+T A Sbjct: 4 SPFFRALSDP-DNFTLTLELVPGRSGRGTGHDRALAVARQAVADGRLTAVSITENAGGQV 62 Query: 67 RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGS- 125 + I GLE HL+C D +++ + + GI ++ + GD P Sbjct: 63 ALSPEVLGVEICA-LGLEVIVHLSCKDKNRNQMESQLFAWDRLGISDLLVITGDYPKPGY 121 Query: 126 --------GKPEMYASDLVTLLK-----------------EVADFDISVAAYPEVHPEAK 160 + A DL+ ++ + F VA P H E Sbjct: 122 RGLSKPVFDLDSVQALDLIGVMNRGGWPSGGEKARPNPLLQTTGFVKGVALSPFKHSE-P 180 Query: 161 SAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQA 220 + L+RK+ AGA+ ITQ +D + G + G + + + K A Sbjct: 181 ELVMQYVKLRRKLAAGADYIITQIGYDARKFQEVLLFLERQGQGRVPVLGNVFIPSLKVA 240 Query: 221 KKF--ADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHF 274 + ++ IP + + K A ++ +L G H Sbjct: 241 ELMYRGEIPGCVIPEKLYTTMQQEARSPDRGKKARLMRAAALLAVLRGLGYAGAHI 296 >UniRef50_Q64DN7 5-10-methylenetetrahydrofolate reductase n=3 Tax=environmental samples RepID=Q64DN7_9ARCH Length = 306 Score = 160 bits (404), Expect = 8e-38, Method: Composition-based stats. Identities = 56/301 (18%), Positives = 107/301 (35%), Gaps = 29/301 (9%) Query: 9 RDALNQSLAEVQ-GQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGER 67 + + + E++ G+ + E P + ++ + + L + +VT S Sbjct: 3 DEIYSDLMRELREGEYVFTGELEPEKAGDVNEPIE-MARELVGM-VVACNVTDNPQSFAY 60 Query: 68 DRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK 127 + + I+ TG+E L C D L + G+++I+AL GD Sbjct: 61 VNSMAASYLIQKETGMECVYQLRCSDRNRMALLSDVLGAGALGLKNILALAGDHVSLGDT 120 Query: 128 PE---MYASD---LVTLLKEVADFDISVAAY-----PEVHP------EAKSAQADLLNLK 170 P+ ++ D L+ L++ + D + P++H A +A++ +K Sbjct: 121 PDAKPVFDLDSTTLIKLIRTMVDDGKDLGGNEIHNPPKLHVGGAAAPGAAHLKAEVGKVK 180 Query: 171 RKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFAD-MTNV 229 RK++AG TQ + + +F D +DV I+ GI P F QA F + V Sbjct: 181 RKINAGVEYLQTQVVYYTDVLDKFFDELGK--VDVPILVGIFPARTFGQADFFDKYVAGV 238 Query: 230 RIPAWMAQMFDGLD------DDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMS 283 +P + E V ++ L H + + Sbjct: 239 DVPPDYLEAMRATKAIKDKEKKKEEVDRVNIEFFTGFLEHLKGTPAAGCHMMAVGYPRII 298 Query: 284 Y 284 Sbjct: 299 P 299 >UniRef50_Q5TWY6 Methylenetetrahydrofolate reductase n=1 Tax=Anopheles gambiae RepID=Q5TWY6_ANOGA Length = 320 Score = 159 bits (403), Expect = 1e-37, Method: Composition-based stats. Identities = 68/310 (21%), Positives = 131/310 (42%), Gaps = 37/310 (11%) Query: 7 SQRDALNQ--SLAEVQGQINV--SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGA 62 S LN+ + + G + V S E + L RL+ +P F ++ + + Sbjct: 17 SLHTKLNRIFNSSTTSGPVPVHYSIEIA-AKDDFDIDQL----KRLTP-QPVFCALPWIS 70 Query: 63 NSGERDR-------THSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIV 115 + R T + + +++C + T ++ + R GIR++ Sbjct: 71 DDNLRYADDFLRSPTLQLTARL-RENQYTVLNNVSCYNITEQQVDQLLR---ATGIRNLF 126 Query: 116 ALRGDLPPGSGKPEMYASDLVTLLKEVAD-------FDISVAAYPEVHPEAKSAQADLLN 168 +RGD + + A LV L++ + F I+V YP H ++ S +L Sbjct: 127 VIRGDTVSPGQQFQNSA-GLVQHLRKWQEQQPNHRQFTIAVGGYPYGHYQSSSQTVELHY 185 Query: 169 LKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTN 228 L+ K+ GA+ +TQ +D S+LR+RDRC AGI + IIPGI +++ + ++T Sbjct: 186 LRAKISQGADFLLTQTLYDAPSFLRYRDRCREAGITIPIIPGIYVPHSYRHLQALLNLTR 245 Query: 229 VRIPAWMAQMFDGLDDD-AETRKLVGANIAMDMVKILSREG-------VKDFHFYTLNRA 280 + + + F+ +D + + + +V+ L + +K HF+T N+ Sbjct: 246 IELGPTVRDAFEAHANDAPDQFQAFMVEYFVGVVRELLQMNATTSSDPIKLVHFFTFNKF 305 Query: 281 EMSYAICHTL 290 + + L Sbjct: 306 HLLQEVLGKL 315 >UniRef50_C5F201 Methylenetetrahydrofolate reductase n=2 Tax=Helicobacter RepID=C5F201_9HELI Length = 303 Score = 159 bits (402), Expect = 1e-37, Method: Composition-based stats. Identities = 39/290 (13%), Positives = 97/290 (33%), Gaps = 24/290 (8%) Query: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79 + ++EF P + ++ K T + + + +++ Sbjct: 13 SNEKCFTYEFSAPPSFSLDTFFDALQQENLVSKIHAFICTDSPLAKLKHNSILASLKLQN 72 Query: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS------ 133 L + ++ D +++ + +R I+AL GD +P+ Sbjct: 73 TFNLPSITTISMRDRNTLAIQSELIGMNSLDLRLILALTGDPIRHGNQPQAKGVFEGNSL 132 Query: 134 ------DLVTLLKEVADFDISVAAYPE-----VHPEAKSAQADLLNLKRKVDAGANRAIT 182 + K++ + I P ++ + + ++ K+ GA+ IT Sbjct: 133 LLLKIIQQLNQAKDINNHPIQGDFKPFYAFSVLNSYSNKKENLYKKMQEKIQNGASAIIT 192 Query: 183 QFFFDVESYLRFRDRC----VSAGIDVEIIPGILPVSNFKQAKKF-ADMTNVRIPAWMAQ 237 Q +D++ C + + +I G P++++K A + V IP + Sbjct: 193 QPIYDLDIAQELLQWCDKINQESSTNCTLIFGFFPITSYKTALFLHNKLPGVFIPQSWLE 252 Query: 238 MFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAIC 287 + + +G + + + L + K H + N+ ++ I Sbjct: 253 TMEKASHNNTEL-EIGLEKSQRLFENLCKIQAK-IHLMSSNKVDIIGKIL 300 >UniRef50_A9G9E1 Methylenetetrahydrofolate reductase n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9G9E1_SORC5 Length = 303 Score = 156 bits (395), Expect = 8e-37, Method: Composition-based stats. Identities = 53/308 (17%), Positives = 101/308 (32%), Gaps = 30/308 (9%) Query: 7 SQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE 66 + + + L+E Q VS E PPR ++E+ L ++ ++ V + S Sbjct: 2 VTKSKMERLLSERQ--FLVSAELTPPRHYDLEKLLKHA-RNMAGC-VDVVQINDHLLSQA 57 Query: 67 RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG 126 R ++ +K GLE + L+ G+ +I+ L G Sbjct: 58 RCANMAVGHFVKQE-GLEPVLQFSLRHKNKIALQGDLLGMAALGLSNIIVLGGYPCAIGS 116 Query: 127 KPEMY---------ASDLVTLLKEVADFDIS--VAAYPEVHPEAKSA-------QADLLN 168 P+ A +L L V+ P H + Sbjct: 117 DPDAKEVSDVDSYAAIELTRRLTREGKLFNGDVVSPAPYFHVGTIDFPCAEQAIAGAMDR 176 Query: 169 LKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGI--DVEIIPGILPVSNFKQAKKFADM 226 L K+DAGA+ Q F++ S R+ V G+ I I P + + + Sbjct: 177 LAAKIDAGASFIQVQAVFELASMRRWMAAVVERGLHERAHFIAAIFPFAGVDRLSFLQKV 236 Query: 227 TNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSR-EGVKDFHFYTLNRAEMSYA 285 + +P + + D I +++++ L G+ H ++ + Sbjct: 237 PGLVVPDHLIERVRLSGDAEGE----SYRITLELIRGLRDIPGLSGIHMRSIGAEDWVPR 292 Query: 286 ICHTLGVR 293 + G+R Sbjct: 293 LVDEAGLR 300 >UniRef50_D1B0C6 Methylenetetrahydrofolate reductase n=1 Tax=Sulfurospirillum deleyianum DSM 6946 RepID=D1B0C6_SULD5 Length = 304 Score = 155 bits (393), Expect = 1e-36, Method: Composition-based stats. Identities = 46/303 (15%), Positives = 101/303 (33%), Gaps = 29/303 (9%) Query: 12 LNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTH 71 L + +++ ++ E P E + K S T + + Sbjct: 2 LESFIEKLKHDSLLTLETTPIHEPTFEPIIEKIAQLGLDKKVDGFSTTDNPLARLKYNAL 61 Query: 72 SIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL------PPGS 125 +++R ++ D L++ N +R I+ L GD P Sbjct: 62 FGALKLQNRFHKPVIATMSMRDRNKLALQSDLLGANENDLRTILCLTGDPASASDQPALK 121 Query: 126 GKPEMYASDLVTLLKEVADFDISVAAYPEV------------HPEAKSAQADLLNLKRKV 173 G E ++ L+ +++ I + P + A + + + + K+ Sbjct: 122 GVFEGNSTLLMDIIQCFNA-GIDYSGKPFKTQPKPIYPFAVCNAHANTPRHLMKKMATKM 180 Query: 174 DAGANRAITQFFFDVESYLRFRDRCVSAGIDV-------EIIPGILPVSNFKQAKKF-AD 225 GA ITQ + +E+ + A ++ E+I G P+ + A+ A Sbjct: 181 SHGAVGIITQPVYSMENATMLVELLKEAKKEIGKETHEAELILGFFPIIKLRTAQFLSAH 240 Query: 226 MTNVRIPAWMAQMFDGLDDDAETRK-LVGANIAMDMVKILSREGVKDFHFYTLNRAEMSY 284 + V +P + +E + VG +++ ++L + H + N E+ Sbjct: 241 VPGVHVPTLWMEKLAHAKKISEAEEHKVGFELSLQTFRMLKKVH-PKIHMMSANNFELIA 299 Query: 285 AIC 287 + Sbjct: 300 DLL 302 >UniRef50_B9KC45 Methylenetetrahydrofolate reductase n=6 Tax=Thermotogaceae RepID=B9KC45_THENN Length = 281 Score = 155 bits (392), Expect = 2e-36, Method: Composition-based stats. Identities = 50/294 (17%), Positives = 99/294 (33%), Gaps = 42/294 (14%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 ++ V E PR + + + ++ +VT R + + + Sbjct: 5 LESGKCVVLEVLTPRGTN-LKKFLDFTEKAWETGIDAFTVTDMPMGRVRMAPWA-VSHLL 62 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP------EMYA 132 +G E H T +++ GI +++ L GD P P ++ Sbjct: 63 VESGKEVLMHFTRNTRNMIRIQSDLLGCHALGIENLLLLSGDDPSHGDYPQTTSVNDVDI 122 Query: 133 SDLVTLLKEVA--------------DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGAN 178 DL+ L K + +F + A P + DL K+K++AG + Sbjct: 123 LDLIRLTKLLNEGTDLAGNRMYGKTNFFVGGALNPFS-------EKDLERAKQKIEAGVD 175 Query: 179 RAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQM 238 +TQ F + + +++ +I+ I N KQ F+ + + IP + Sbjct: 176 FLVTQPLFQRDVAQKIKEKL-----STKILVSIAFFENAKQMNHFSGVPGIEIPKEI--- 227 Query: 239 FDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYT----LNRAEMSYAICH 288 + + E K + V+ +R V F+ L + M + Sbjct: 228 IESAEKGDEHVKERSFEAVLRFVEE-TRNIVDGFYIVAVVKDLEKIRMVVEVAK 280 >UniRef50_Q9HJI8 5, 10-methylenetetrahydrofolate reductase related protein n=3 Tax=Thermoplasma RepID=Q9HJI8_THEAC Length = 270 Score = 153 bits (388), Expect = 5e-36, Method: Composition-based stats. Identities = 45/274 (16%), Positives = 93/274 (33%), Gaps = 25/274 (9%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 S E P R L + D L + ++ + I + Sbjct: 17 NFVKSVEIVPSRN-FGTDDLIAAADML-DGRVNALTCPENPRGSPGIDPIMALYIISNER 74 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP----PGSGKPEMYASDLVT 137 + PH+T D + + GIR+ + GD E+ +++ Sbjct: 75 NIIPVPHITPRDKNRVHILSQIETAQKVGIRNFFTIGGDPINPKYESREVREIDVMEIIR 134 Query: 138 LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLR-FRD 196 ++K + + A P + + K+ +GA+ I+Q + E + + Sbjct: 135 MIKGRENAIVGAALNPYR-------DVEPEIVGAKIKSGADFFISQAVYSAEYLQKDWIK 187 Query: 197 RCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANI 256 + + ++I G LP++ Q K ++ + IP + Q ++E I Sbjct: 188 K-----RNFKLIAGFLPLTKKSQVKFSENL-GIVIPDSVKQRLL----NSEDVISTSMKI 237 Query: 257 AMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 ++ + +E V H L E++ I T+ Sbjct: 238 ITEVFDEV-KEYVDGIHIMPLGHNEIAAQILETI 270 >UniRef50_C7MZV4 Methylenetetrahydrofolate reductase n=1 Tax=Saccharomonospora viridis DSM 43017 RepID=C7MZV4_SACVD Length = 292 Score = 151 bits (382), Expect = 3e-35, Method: Composition-based stats. Identities = 56/298 (18%), Positives = 105/298 (35%), Gaps = 24/298 (8%) Query: 1 MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY 60 M+ + LA++ G N+S+E P ++ E + + + P V+VT Sbjct: 1 MTTKSEVADSRRPRGLADLVG--NISYEVMPFKSVE-----RAVLADVPTSIPLTVTVTE 53 Query: 61 GANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDA-TPDELRTIARDYWNNGIRHIVALRG 119 + D T + + G PHL + +R + G+ + + G Sbjct: 54 ---AKGIDTTLDFTERLMR-HGYTVTPHLAARQFVDDNHVREVIDRLQTAGVNSVFIVGG 109 Query: 120 DLPPGSGKPEMYASDLVTLLKEVADFD-ISVAAYPEVHPEAKSAQADLLNLKRKVDAGAN 178 D P +G+ L + + F + + YPE H + +L LK+K A Sbjct: 110 DAPKPAGRFHSAYMLLQAMQELGHPFSEVGIGGYPEGHANIPQSDIELA-LKQKAPL-AT 167 Query: 179 RAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQM 238 R +TQ FD + + +GID+ I G+ N ++ + + + A Sbjct: 168 RILTQICFDANTTANWAAGVAKSGIDLPIYVGMPGPVNRQKLVRISAGIGLGQSARF--- 224 Query: 239 FDGLDDDAETRKLVGANIAMDMVKIL------SREGVKDFHFYTLNRAEMSYAICHTL 290 + L G + + L R ++ H +T N + + L Sbjct: 225 LQKQQNLLWRFLLPGGYNPTKLARRLGSAVPKVRSNIRGLHIFTFNEIQKTEQWRRKL 282 >UniRef50_Q9EYI8 Methylenetetrahydrofolate reductase n=2 Tax=Actinomycetales RepID=Q9EYI8_STRNO Length = 284 Score = 150 bits (379), Expect = 5e-35, Method: Composition-based stats. Identities = 54/280 (19%), Positives = 91/280 (32%), Gaps = 32/280 (11%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 S E T + L + D + +++T+ A T R G Sbjct: 9 FSLEM----TGKDVPRLEEARDGIPPG--TRINITFLAGEDTA--TRLTAARAVKRLGFV 60 Query: 85 AAPHLTCIDA-TPDELRTIARDYWNNG-IRHIVALRGDLPPGSGKPEMYASDLVT--LLK 140 PH++ + L +G ++ + GD G P A ++ LL+ Sbjct: 61 PVPHISARRLPSRPALEEFLAGLAAHGTAENVFVVGGDPARPEG-PYADALAVLRTGLLR 119 Query: 141 EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDA-GANRA----ITQFFFDVESYLRFR 195 + +A YPE HP +A L K A A+R ITQF FD + L + Sbjct: 120 RHGVRHVGIAGYPEGHPGITD-RALWSALTDKAAAIDADRFGGDVITQFGFDADPVLAWL 178 Query: 196 DRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQM-------FDGLDDDAET 248 + + G+ + + G+ + ++ +A V A +A+ G Sbjct: 179 EALRARGVRLPVRVGVPGPAGVRRLLGYATRFGVGTSASVARKYGFSLTNLMGTTGPDRF 238 Query: 249 RKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICH 288 + R GV HFYT + Sbjct: 239 LHALADRY------DPGRHGVVKVHFYTFGGLRATAEWVD 272 >UniRef50_A7HND8 Methylenetetrahydrofolate reductase n=1 Tax=Fervidobacterium nodosum Rt17-B1 RepID=A7HND8_FERNB Length = 293 Score = 150 bits (378), Expect = 9e-35, Method: Composition-based stats. Identities = 45/291 (15%), Positives = 94/291 (32%), Gaps = 34/291 (11%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + E PPR +E+ + I + + ++VT R + I Sbjct: 11 KKRFILETLPPRGVVLEKYVDFCIKAV-ESGAEIIAVTDLPMGSARVSPIAPA-HILVEK 68 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASD------- 134 G++ H + + GI++++ L GD P P + Sbjct: 69 GIDVIMHFSRTTRNAIRIEGDLIASHMLGIKNLLILSGDDPRVGTYPFSSCIEDFSIYDV 128 Query: 135 --LVTLLKEVAD------------FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRA 180 LV LL E + F+ P K + + + K++ G Sbjct: 129 FKLVKLLNEKGEDLAGLKIFGKFSFNSGGV----FSPFEKDYKQTIQRMNTKIETGCLFF 184 Query: 181 ITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFD 240 ++Q F+ + L F + + +I ++ + +Q + F+ + V +P Sbjct: 185 VSQPVFNESTILNFLKKAEGDLNETKIYVSLMVFESVQQLEYFSKVPGVFVPKEYF---- 240 Query: 241 GLDDDAETRKLVGANIAMDMVKILSREGVKDFHF-YTLNRAEMSYAICHTL 290 D K + +++ L V+ F+ T E+ + + Sbjct: 241 -HQKDDRALKNYSYKNCLGIIEKL-SPYVQGFYLTSTTKDLEIIKGLAEVI 289 >UniRef50_C0QY90 Methylenetetrahydrofolate reductase n=2 Tax=Brachyspira RepID=C0QY90_BRAHW Length = 308 Score = 149 bits (377), Expect = 1e-34, Method: Composition-based stats. Identities = 48/311 (15%), Positives = 100/311 (32%), Gaps = 27/311 (8%) Query: 4 FHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGAN 63 + + L E + + + E P ++ D S VT Sbjct: 1 MSDNSVENFIDKL-ENKDEYTFTLEISPQAKFDLGYIKDKIDDAKISDYIDAFVVTDSPF 59 Query: 64 SGERDRTHSIIKGIKDRTGL--EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDL 121 + + + ++ R T D L+ IR ++A+ GD Sbjct: 60 ANLKISSILAALQLQQRLNNNKPFIATQTMRDKNSIALQNDLIGANYFDIRMVLAVTGDP 119 Query: 122 PPGSGK------PEMYASDLVTLLKEVA-DFDIS--------VAAYPEV--HPEAKSAQA 164 G + E + L+ ++K++ + YP + AK+ + Sbjct: 120 INGGNQKQAKSVFEGNSELLIAIIKDLNKGKSLGEFAFKEPLKPIYPFCVINSYAKNNDS 179 Query: 165 DLLNLKRKVDAGANRAITQFFF---DVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAK 221 + L +K ++G TQ + +E L + D + ++PG PV +K A Sbjct: 180 LKVRLAKKANSGVKAIFTQPIYEAERLELLLEWIDELPLKNKPI-LVPGFFPVLTYKTAY 238 Query: 222 KF-ADMTNVRIPAWMAQMFDGLDD-DAETRKLVGANIAMDMVKILSREGVKDFHFYTLNR 279 + IP + E K V ++ D+ + ++ K H ++N Sbjct: 239 FIYYKLPGAYIPEDWLNKLKKASNKSPEEEKRVAVKLSSDLFHNMLKKH-KKMHIMSMNN 297 Query: 280 AEMSYAICHTL 290 + ++ + Sbjct: 298 YDFVVSLLKNI 308 >UniRef50_A8A9S7 Methylenetetrahydrofolate reductase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=A8A9S7_IGNH4 Length = 329 Score = 147 bits (372), Expect = 3e-34, Method: Composition-based stats. Identities = 49/273 (17%), Positives = 90/273 (32%), Gaps = 39/273 (14%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 VS E P E ++R S + ++VT + Sbjct: 72 DFAVSAEVEPWGPEE--------LERASKWRVDALNVTDNPLGLPHLDSV-WASAALASK 122 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKE 141 G E LTC T + L + +G+ +++AL GD P + ++ A LV L++ Sbjct: 123 GKEVIAQLTCRGRTREALASSLLALDASGVNNVLALTGDWAPNA-AFDLDAVRLVCLVQA 181 Query: 142 VAD-------------FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDV 188 + + VA+ P + L RK AGA A TQ F Sbjct: 182 LRKGVDWEGRKTRRVRLSVGVASNPY-------FSYEEKRLLRKAHAGAQFAQTQPVFKK 234 Query: 189 ESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAET 248 E + + + +P +L ++ K + + V + + + Sbjct: 235 ELLYKIKKY------PLPTVPSLLLTTSRKVVRALMER-GVDA-KEFYEELVKAKREGKA 286 Query: 249 RKLVGANIAMDMVKILSREGVKDFHFYTLNRAE 281 +LV +++M + + H R + Sbjct: 287 DELV-LKKSLEMYEEAYSSELPGVHLMAPGRPD 318 >UniRef50_Q251W5 Methylenetetrahydrofolate reductase n=3 Tax=Bacteria RepID=Q251W5_DESHY Length = 561 Score = 146 bits (370), Expect = 6e-34, Method: Composition-based stats. Identities = 47/307 (15%), Positives = 93/307 (30%), Gaps = 31/307 (10%) Query: 11 ALNQSLAEVQGQINVSFEFFPPRTSE---MEQTLWNSIDRLSSLKPKFVSVTYGANSGER 67 QSL + ++V++E P R + E L + K +++T Sbjct: 42 RFKQSLLDP-NTLSVTWELVPGRGAREKAQESALLAAEQAAKGGKVHALTITDNPGGNPA 100 Query: 68 DRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGD------- 120 + + I G+E H TC D +++ + +R ++ + GD Sbjct: 101 ILADYLGQEILK-LGIEPLVHFTCKDKNRNQMESQLYALDRAEVRSLLVMTGDYTVSGFK 159 Query: 121 --LPPGSGKPEMYASDLVTLL--------------KEVADFDISVAAYPEVHPEAKSAQA 164 P + +L+ + + +DF A P EA+ Sbjct: 160 GRPKPVFDLDPTHTLELIAQMNEGLGIPGPKGMSYHQPSDFFAGAAVSPFKGTEAEQM-V 218 Query: 165 DLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGI-LPVSNFKQAKKF 223 LK+KV +GA +TQ +D ++V ++ I + + Sbjct: 219 QYYKLKKKVTSGAQFIVTQLGYDARKIHEVLQFMKLNDLNVPLVGNIYILPFGAAKIMNQ 278 Query: 224 ADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLN-RAEM 282 + + + D + A M ++ G H N + E Sbjct: 279 NQLPGCVVTDKLLAEIDKERTAEDKGVSARLLRAAKMYALMKGMGFAGVHIGGHNIKYEQ 338 Query: 283 SYAICHT 289 + Sbjct: 339 VEYVIEK 345 >UniRef50_B1ZRF7 Methylenetetrahydrofolate reductase n=2 Tax=Verrucomicrobia RepID=B1ZRF7_OPITP Length = 538 Score = 146 bits (368), Expect = 1e-33, Method: Composition-based stats. Identities = 48/292 (16%), Positives = 92/292 (31%), Gaps = 32/292 (10%) Query: 14 QSLAEVQGQINVSFEFFPPRTSEMEQTLWNSI----DRLSSLKPKFVSVTYGANSGERDR 69 + E + + E R E++ + D + + ++S+T A + Sbjct: 5 REKLEQADRFLIGTELVSVRGGMSERSAVKARTFANDLVDADAIDWISITDNAGGNPQLA 64 Query: 70 THSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLP---PGSG 126 ++ K I G E HLTC D + L + A + G +I+A+ GD P G Sbjct: 65 PTALGKPIL-YAGKEVVIHLTCKDLNRNALESEAWLLHSEGFNNILAMTGDYPVAGAGGT 123 Query: 127 KPEMYASDLVTLLKEVADFDIS----------------------VAAYPEVHPEAKSAQA 164 ++ D V L+ + + A Sbjct: 124 AKPVFDIDSVGLISMLDQMNRGLDPNVGQSGPRKPRFEGTNFLVGAVTTNFKLHEGEVMP 183 Query: 165 DLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA 224 L K+ GA I Q FD + + + G + + + + A+ FA Sbjct: 184 QYAKLAAKIGVGARFIINQIGFDARKQSELLAYLRAHELGHVPLIGNVYLLSPRVAELFA 243 Query: 225 D--MTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHF 274 + + V + + ++ A+ K A + I G + + Sbjct: 244 EGRIPGVVVSPALRELCRRHAGGADGGKAFFTEFAAKQIAIYRGLGYRGVYL 295 >UniRef50_Q60FX0 Methylenetetrahydrofolate reductase n=1 Tax=Sphingomonas paucimobilis RepID=Q60FX0_PSEPA Length = 288 Score = 145 bits (367), Expect = 2e-33, Method: Composition-based stats. Identities = 61/277 (22%), Positives = 101/277 (36%), Gaps = 29/277 (10%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 S E P + + L N+ + +SVT+ + DR K I+ G Sbjct: 18 YSLEITP----KDVEALENAAHMIPPG--TLISVTFLPGAEYEDRA-RAAKRIQ-ELGFR 69 Query: 85 AAPHLTCID-ATPDELRTIARDYW-NNGIRHIVALRGDLPPGSGKPEMYASDLV--TLLK 140 PHL+ +LRT ++H+ + GD G E A L+ +LK Sbjct: 70 PVPHLSARRLIDEADLRTYLDMLKGVIDLKHVFVIAGDPNEPLGIYE-DALALIDSGILK 128 Query: 141 EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDA----GANR-AITQFFFDVESYLRFR 195 E ++ YPE HP+ + + KV + G + +TQF FD E L + Sbjct: 129 EYGIEHCGISGYPEGHPDITD-EKLAKAMHDKVASLKRQGIDYSIMTQFGFDAEPVLEWL 187 Query: 196 DRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGAN 255 + S GID + G+ ++ K +FA V A + + + L+G+ Sbjct: 188 KQIRSEGIDGPVRIGLAGPASIKTLLRFAARCGVGTSAKVVKKY-----GLSITSLIGSA 242 Query: 256 IAMDMVKIL-----SREGVKDFHFYTLNRAEMSYAIC 287 +++ L G HFY + Sbjct: 243 GPDPVIEDLTPVLGPEHGQVHLHFYPFGGLVKTNEWI 279 >UniRef50_B0TCJ7 Methylenetetrahydrofolate reductase n=6 Tax=Bacteria RepID=B0TCJ7_HELMI Length = 258 Score = 142 bits (359), Expect = 1e-32, Method: Composition-based stats. Identities = 49/216 (22%), Positives = 86/216 (39%), Gaps = 10/216 (4%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 ++ E P E+ L + ++ + P+ + + R+ R Sbjct: 13 ITVELVP----RSEEALISELEMIQQEFPQVMGINIPDLLRFPLRSWD-ACTCAKRYFAT 67 Query: 85 AAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVAD 144 A PH+ ID PD +A NGI ++ + GD P + +Y + + +++ Sbjct: 68 AIPHIRAIDLNPDAPLQMAEQLQQNGIAEVLIVTGDPPQDMSRK-VYPTTSIDVIRRFKR 126 Query: 145 FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGID 204 + Y + P S + + +KRK+DAGA+ TQ FFD LRF + Sbjct: 127 ELPDMKVYAAIDPYRNSLRKEYDYIKRKIDAGADGFFTQPFFD----LRFMEIYGEMLEG 182 Query: 205 VEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFD 240 ++ GI PV+ K A + +V PA + Sbjct: 183 QQVFWGISPVTTEKSACYWETKNHVLFPADFEPTLE 218 >UniRef50_C4DNM1 Methylenetetrahydrofolate reductase n=1 Tax=Stackebrandtia nassauensis DSM 44728 RepID=C4DNM1_9ACTO Length = 289 Score = 141 bits (357), Expect = 2e-32, Method: Composition-based stats. Identities = 65/301 (21%), Positives = 100/301 (33%), Gaps = 35/301 (11%) Query: 1 MSFFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTY 60 MS A R + ++ + + + FE P +DR + P+ +VT Sbjct: 1 MSMSAALSRVRMRRTASRLLAEPR--FEVLP----------LERVDREVAALPRGTTVTI 48 Query: 61 GAN-SGERDRTHSIIKGIKDRTGLEAAPHLTCIDA-TPDELRTIARDYWNNGIRHIVALR 118 A+ S T + GL PHL+ EL + + + GIR + Sbjct: 49 TASPSRGTMATVETAERFAA-LGLRPVPHLSARGMRDDAELVEVVQRLDHAGIRDAFVVG 107 Query: 119 GDLPPGSGKPEMYASDLVTLLKEVADF-----DISVAAYPEVHPEAKSAQADLLNLKRKV 173 GD S D + LL+ + D DI + AYPE HP L K Sbjct: 108 GDASSASAVFP----DGLALLQAMDDIGHRLHDIGIPAYPEGHPSIDD-DTLWAALAAKR 162 Query: 174 DAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPA 233 A A+TQ FD E+ RF + G D+ I+ GI + + + + Sbjct: 163 R-YATYAVTQLCFDAEAICRFTVQARQRGFDLPILAGIPGAVDTAKLLRVGLRIGIGDS- 220 Query: 234 WMAQMFDGLDDDAETRKLVGANIAMDMVKIL------SREGVKDFHFYTLNRAEMSYAIC 287 + G G +V+ L R + H YT N + Sbjct: 221 --LRFVRGNRSVLRKLLRPGGYRPDGLVRKLDGRVRDGRCELAGAHIYTFNDVAATARWL 278 Query: 288 H 288 Sbjct: 279 K 279 >UniRef50_D0XP42 Methylenetetrahydrofolate reductase n=1 Tax=Brevundimonas subvibrioides ATCC 15264 RepID=D0XP42_9CAUL Length = 293 Score = 141 bits (357), Expect = 2e-32, Method: Composition-based stats. Identities = 59/276 (21%), Positives = 103/276 (37%), Gaps = 26/276 (9%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 S E T++ +L + + +++ + R H+ ++ G + Sbjct: 22 FSLEM----TAKDVPSLEEAARFIPQG--TRIAIAFLPGETFEARLHAAVRV--RALGFD 73 Query: 85 AAPHLTCIDA-TPDELRTIARD-YWNNGIRHIVALRGDLPPGSGKPEMYASDLVT--LLK 140 APH++ + ELRT + GI+ + + GD P G P A L+ +L Sbjct: 74 PAPHISARRIASETELRTFLERLAADAGIKRLFVVAGDPPVPEG-PYEDALSLIRSGMLA 132 Query: 141 EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDA----GANR-AITQFFFDVESYLRFR 195 + + V+ YPE HP+ + K DA G + +TQF FD + + + Sbjct: 133 GLNLESVGVSGYPEGHPDI-DGDKLWRAMFDKRDALGELGISMTILTQFGFDPDPIVDWI 191 Query: 196 DRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQM----FDGLDDDAETRKL 251 + + GID I G+ + K +FA V A + L A +L Sbjct: 192 AQVRAHGIDALIRIGVPGPAGIKTLMRFAARCGVGTSAKVMSRYGLSITQLIGSAGPDRL 251 Query: 252 VGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAIC 287 +G ++A + R G HFY + Sbjct: 252 IG-DLAARI--DPVRHGDLSLHFYPFGGIAKTAEWV 284 >UniRef50_Q18JC7 5,10-methylenetetrahydrofolate reductase n=2 Tax=Halobacteriaceae RepID=Q18JC7_HALWD Length = 285 Score = 140 bits (354), Expect = 5e-32, Method: Composition-based stats. Identities = 52/266 (19%), Positives = 101/266 (37%), Gaps = 29/266 (10%) Query: 27 FEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEAA 86 FE P + + ++ L + +++T ++T + + G E Sbjct: 23 FELMP------FDSFNDELESLPAGSS--IAITTSP-QLGIEQTVERAEEAAAQ-GYEVV 72 Query: 87 PHLTCIDA-TPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVAD- 144 PH+ +L +IA + G+ + GD +G+ A DL+ +L E+ Sbjct: 73 PHIAARYVEDEAQLASIAERLSDAGVNDVFIPGGDREEPAGE-FTSAYDLLEVLDELPYS 131 Query: 145 -FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGI 203 DI + YPE H + + + + +K A +TQ +D E+ L + + G+ Sbjct: 132 FEDIGITGYPEGHDFIEDEELAMA-MDQK-APHATYIVTQLCYDPETILEWVESTRERGV 189 Query: 204 DVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLV----GANIAMD 259 D+ I GI V N+++ + + V + E + + G D Sbjct: 190 DLPIEIGIPGVMNYQKLLQISQKVGVGDS---IRFLRKTTGVFEFVRQLIGSRGVYEPDD 246 Query: 260 MVKILSR------EGVKDFHFYTLNR 279 ++ LS ++ H YT N+ Sbjct: 247 LINGLSPYVEDEYYNIRGVHIYTFNQ 272 >UniRef50_Q7VHW2 Methylenetetrahydrofolate reductase n=3 Tax=Helicobacter RepID=Q7VHW2_HELHP Length = 301 Score = 140 bits (352), Expect = 8e-32, Method: Composition-based stats. Identities = 39/295 (13%), Positives = 86/295 (29%), Gaps = 41/295 (13%) Query: 22 QINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRT 81 + +S E P + ++ L + L T + + + ++ Sbjct: 15 EPFLSVEIAPSISGRFDENLLEDLKTLKLAH--AFVCTDSPLARFKPSSILSSLKFQNAL 72 Query: 82 GLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG------KPEMYAS-- 133 ++ D L G+R + L GD E + Sbjct: 73 QKPVICTISMRDRNSIALCGDILSVNELGLRTFLTLTGDSIKNGDCLQSKGVFEDNSLKL 132 Query: 134 ----------------DLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAG- 176 L +K + +F + ++ A + + +++K+ + Sbjct: 133 GHIIDELNCGRALNGKSLKENIKRIYNFQV-------INAYANNPLSLKNKMRKKLSSCE 185 Query: 177 ANRAITQFFFDVES----YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNVRI 231 + TQ + + + + I ++ G PV ++K A + V I Sbjct: 186 IHALFTQPVYSLNAAEFLLQSLEEIKSECNIKSALVLGFFPVLSYKTALFLRDKLPGVYI 245 Query: 232 PAWMAQMFDGLDD-DAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYA 285 P Q + + + VG I+ + L FHF + N+ + Sbjct: 246 PNEWVQKLEKAHNKGKDEENKVGLEISHSLFMELKSVH-NKFHFMSANKPSLVKE 299 >UniRef50_A4FL79 Methylenetetrahydrofolate reductase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FL79_SACEN Length = 282 Score = 136 bits (342), Expect = 1e-30, Method: Composition-based stats. Identities = 49/283 (17%), Positives = 95/283 (33%), Gaps = 33/283 (11%) Query: 27 FEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEAA 86 FE P R + + L V+VT + T + + G Sbjct: 19 FEVLPLRG------VVEQVGNLPEG--TTVTVTSSP-KKGVEATLDVAARV-RGLGHHVV 68 Query: 87 PHLTCIDAT-PDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVADF 145 PHL T P L + G+ + A+ GD +G P A L+ ++E+ Sbjct: 69 PHLAARLLTGPAHLAAVLDRIEGLGMTEVFAVAGDSAEPAG-PYPDALSLLRAMEELGRR 127 Query: 146 --DISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGI 203 + + YPE H A + + K A A+ ++Q +D + + + G+ Sbjct: 128 PSRVGITGYPERHAFIPDATT-ISAMSEK-AAHADYIVSQICYDPHALASWVKDVRARGV 185 Query: 204 DVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIA-MDMVK 262 + I G+ V + + + + + + G+ + ++ Sbjct: 186 VLPIHIGVPGVVDVHRLLRISLKIGLGESMRFLRKQHGV------VTKLLTRYTPEELFD 239 Query: 263 ILSRE------GVKDFHFYTLNRAEMS----YAICHTLGVRPG 295 LS G+ +HF+T N + + + +G P Sbjct: 240 ELSPHLADPAYGIAGWHFFTFNEVDRTDRWRQDLLARIGEVPA 282 >UniRef50_A5EXW9 Methylenetetrahydrofolate reductase n=1 Tax=Dichelobacter nodosus VCS1703A RepID=A5EXW9_DICNV Length = 288 Score = 136 bits (342), Expect = 1e-30, Method: Composition-based stats. Identities = 51/280 (18%), Positives = 96/280 (34%), Gaps = 32/280 (11%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 S E P + +E + ++ VT+ N + T + + GL Sbjct: 13 YSLEVTP-KFAESIANFTAYFAKETAAY-----VTFLPN-SDFLSTIR-ATVLLQQNGLR 64 Query: 85 AAPHLTCID-ATPDELRTIARDYWNNGIRHIVALRG--DLPPGSGKPEMYASDLVT--LL 139 PH+ + EL ++ G+R ++ + G D P G P L+ ++ Sbjct: 65 TVPHIAARSLHSEAELEQGLAQLYDAGVRDLLLIAGSIDQPRG---PWASTLALLASGII 121 Query: 140 KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGAN------RAITQFFFDVESYLR 193 + I AA+PE HP +LL ++ A A+ +TQF F + + Sbjct: 122 QNYQWHSIGFAAHPEGHPRIG--ADELLYTLQQKQAFADSISAQCYLLTQFCFTAKPIVH 179 Query: 194 FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVG 253 + + GI + I G+ V+ ++A + + + Sbjct: 180 WHRMLQTQGIRLPIHLGVPGVTTIGNLFRYAQLCGIGNSVRF---LRYSQHGLHQFLELS 236 Query: 254 A-NIAMDMVKILSREG----VKDFHFYTLNRAEMSYAICH 288 + + + +G +K HFY L E + H Sbjct: 237 TPELLLSNIVRARAQGELSLLKCLHFYPLGGFEATVRWIH 276 >UniRef50_Q2G4C7 Methylenetetrahydrofolate reductase n=1 Tax=Novosphingobium aromaticivorans DSM 12444 RepID=Q2G4C7_NOVAD Length = 294 Score = 134 bits (339), Expect = 2e-30, Method: Composition-based stats. Identities = 51/287 (17%), Positives = 95/287 (33%), Gaps = 31/287 (10%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 S E T++ E +L ++ + + P ++VT+ R + + + G E Sbjct: 22 FSLEM----TAKDEASLRDAAPLIPADTP--IAVTFLPGEDVAARVAATVAVRQ--LGFE 73 Query: 85 AAPHLTCIDA-TPDELRTIARDYWN-NGIRHIVALRGDLPPG-SGKPEMYASDLVTLLKE 141 PH + + D+ + G+ + GD P + A + Sbjct: 74 PMPHFSARRITSEDDFEGYLKAVVEQAGVERCFIVAGDPPEPVGPYFDTSALIATGAFER 133 Query: 142 VADFDISVAAYPEVHPEAKSAQADLLNLKRKVD----AG-ANRAITQFFFDVESYLRFRD 196 I + +PE HP A+ L++KV G A +TQF FD +++L + Sbjct: 134 SGIKAIGIGGHPEGHPNMTEAEC-WAVLEKKVAEIERRGMAPLIVTQFGFDPDAFLAWLK 192 Query: 197 RCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQM-------FDGLDDDAETR 249 + GID + G+ + K+ FA V + + G + Sbjct: 193 ELRARGIDAPVRIGVPGPAGIKRLLAFAARCGVGASTAVLKKYGISVTNLLGTAGPDKLV 252 Query: 250 KLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL 296 + + G HFY + H + G+ Sbjct: 253 DAFAKGLGPE-------HGKVRLHFYPFGGLTKTLEWIHGYNKKHGI 292 >UniRef50_A8TJJ1 MetFprotein-like protein n=2 Tax=Bacteria RepID=A8TJJ1_9PROT Length = 308 Score = 134 bits (338), Expect = 3e-30, Method: Composition-based stats. Identities = 53/279 (18%), Positives = 90/279 (32%), Gaps = 27/279 (9%) Query: 26 SFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEA 85 S E P + D L+ V+VT+ + T ++ K ++ G E Sbjct: 17 SVETTP----TSAAKVNRFADHLAPG--AAVNVTFLP-GSDPADTVAVSKRLRAE-GFEP 68 Query: 86 APHLTCID-ATPDELRTIARDYWN-NGIRHIVALRG--DLPPGSGKPEMYASDLVT--LL 139 PH+ A L + + G+ + + G D P G+ + DL+ L Sbjct: 69 VPHVAARSLADRAALDSFLGRLKDEAGVTQALVVAGGLDRPVGA---FASSMDLLATGLF 125 Query: 140 KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGAN-----RAITQFFFDVESYLRF 194 + I VA +PE P+ A L K A TQF FD + + + Sbjct: 126 QAHGITRIGVAGHPEGTPDIPEP-ALKDALLWKNRFAAEHGIDMYIETQFCFDAAAIIAW 184 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDA---ETRKL 251 G + I G ++ K KFA + V + + Sbjct: 185 DRTIRGWGNRLPIHLGTPGLATLKTLLKFAQSSGVGPSIRVLTRQARNLAKLLMVQAPDR 244 Query: 252 VGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + +A G++ HFY + +T+ Sbjct: 245 LLVELAAYKASD-PECGIEKLHFYPFGGLAKTADWVNTI 282 >UniRef50_C9KNQ4 Methylenetetrahydrofolate reductase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KNQ4_9FIRM Length = 247 Score = 134 bits (338), Expect = 3e-30, Method: Composition-based stats. Identities = 48/267 (17%), Positives = 92/267 (34%), Gaps = 24/267 (8%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 +S E P R + + + + + +++ R+ I Sbjct: 2 KRISVELVP-RDEDALRGELALLGKFKE-QVDVINIPD--LLRFPTRSWQGAA-IAKEYF 56 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEV 142 E+ PH+ +D D+ + + IR ++ + GD P E+Y ++ V ++ + Sbjct: 57 PESMPHIRAMDIDLDKELAMKDYLREHDIREVLVIEGDPPQDMMH-EVYPTNSVDVIWKF 115 Query: 143 ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAG 202 V Y + S +L +KRK+ AGA TQ FFD+ RF Sbjct: 116 RKEMPEVKVYAGIDQYRGSLSQELYRIKRKLQAGAAGFFTQPFFDM----RFLSVYADML 171 Query: 203 IDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVK 262 +E+ G+ PV + + + +V P D A +++ Sbjct: 172 QGLEVYWGVSPVMSARSQSYWERKNHVVFPHAFEPTLD-----------WSVAFAKEVMD 220 Query: 263 ILSREGVKDFHFYTL--NRAEMSYAIC 287 REG + + + N + Sbjct: 221 FAVREG-NNVYLMPIKTNLEAYLEGVL 246 >UniRef50_B6A4H7 Methylenetetrahydrofolate reductase n=2 Tax=Rhizobium leguminosarum RepID=B6A4H7_RHILW Length = 292 Score = 133 bits (335), Expect = 8e-30, Method: Composition-based stats. Identities = 66/298 (22%), Positives = 98/298 (32%), Gaps = 25/298 (8%) Query: 3 FFHASQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGA 62 LA++ S E TS +L + L FV+ Sbjct: 2 MIAPQSESREKAPLADLLSH--YSIEV----TSRDLPSLQSMTATLPPGSEVFVA----H 51 Query: 63 NSGERDRTHSIIKGIKDRTGLEAAPHLTCID-ATPDELRTIARDYWN-NGIRHIVALRGD 120 E G PH+ + EL T+ G+RH + L GD Sbjct: 52 LPKEDIGLLVRAAAGLRDAGFVPVPHIVARNIRNRPELDTMLARLSEEAGVRHALVLGGD 111 Query: 121 LPPGSGKPEMYASDLVT--LLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGAN 178 +G A DL+ L + I++A YPE HP A D L KVDA A Sbjct: 112 RDDAAGA-FSSALDLIETGLFQTYGIGRIAIACYPEGHPRIAGAVLDTA-LTAKVDAAAR 169 Query: 179 R-----AITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIP- 232 ++QF FD + L F R G+ V + GI + + K+A V Sbjct: 170 AGLDLLLVSQFLFDQKPLLSFARRLRERGVTVPLRVGIAGPAGRTKLLKYALRCGVGASL 229 Query: 233 AWMAQMFDGLDD--DAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICH 288 + + + + ET + + +IA G+ HF+T S Sbjct: 230 RALRERSEIARNVLSGETPEELLIDIAAAQTAE-PDLGISGVHFFTFGDPAQSIRWAE 286 >UniRef50_B9KZH8 Methylenetetrahydrofolate reductase n=2 Tax=Thermomicrobia (class) RepID=B9KZH8_THERP Length = 299 Score = 133 bits (334), Expect = 8e-30, Method: Composition-based stats. Identities = 48/243 (19%), Positives = 87/243 (35%), Gaps = 16/243 (6%) Query: 56 VSVTYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCID-ATPDELRTIARDYWNNGIRHI 114 ++VT G + T + + + G PHL + EL + + + GI + Sbjct: 50 LTVTSSPAHGVK-GTLATALAL-RQHGYRVVPHLAARALRSHQELVLLWQQFVAAGIDEV 107 Query: 115 VALRGDLPPGSGKPEMYASDLVTLLK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKV 173 + GD +G+ + L L++ + I +AAYPE HP + D L + Sbjct: 108 FVVGGDQTEPAGEFPDSRTLLTALVELQPRPRRIGIAAYPEGHPHIPADVLDADLLTK-- 165 Query: 174 DAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPA 233 A A+ AITQ FD ++ +R+ R S G + + + + + + Sbjct: 166 QALADYAITQLVFDPDALVRWLTRMRSRGFTLPLYLCLPGTLRLDRLIRIGLRLGLGTSL 225 Query: 234 WMAQMFDGLDDDAETRKLVGANI-AMDMVKILSRE------GVKDFHFYTLNRAEMSYAI 286 + GL G + D++ L R G+ H+ + N Sbjct: 226 RYLEKQRGLVG---RLLTGGIHYDPSDLLDELVRRPAAIQGGIVGIHWSSFNALASVVEW 282 Query: 287 CHT 289 Sbjct: 283 VAA 285 >UniRef50_C0QKT3 Methylenetetrahydrofolate reductase n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QKT3_DESAH Length = 294 Score = 132 bits (332), Expect = 2e-29, Method: Composition-based stats. Identities = 54/304 (17%), Positives = 103/304 (33%), Gaps = 31/304 (10%) Query: 12 LNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTH 71 + G+ + PP+ +++ + N+I V+ ++ R + Sbjct: 1 MQFRKRLKTGEFARLVQIDPPKGTDVITMVNNAIK--VKGVVDAFLVSEMKSAVMRMTSL 58 Query: 72 SIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMY 131 + + GL+ L+C D L+ GI + + GD P + Sbjct: 59 G-ASLVLQQKGLDTIVQLSCRDRNRLALQGDLLAASALGIAAAMVVEGDPPATGDHVDAK 117 Query: 132 AS-DLV--TLLKEVADFDIS---VAAYPEVHPEAK------------SAQADLLNLKRKV 173 A DL L+K +A + + +L +KR + Sbjct: 118 AVYDLTDEALVKAIASLSKGRDLAGVELAGSVDLPMGVELSTGLRGGEREKELDRMKRMI 177 Query: 174 DAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFA-DMTNVRIP 232 D G +TQ F+ F V G+ IIP +L V + A+ A ++ ++ +P Sbjct: 178 DLGVCFFVTQPLFEFSMTEPFLKIAVKNGVT--IIPTVLLVKSLGMARYMARNLAHIIMP 235 Query: 233 AWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292 + D + ++A+DM+ + G + L + + LGV Sbjct: 236 EHVIDTLQKTPDKVKA----SISLAVDMIHEVREMGFGGVNVSCLGWEDKLPEV---LGV 288 Query: 293 RPGL 296 GL Sbjct: 289 MKGL 292 >UniRef50_Q05FX5 Methylenetetrahydrofolate reductase n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FX5_CARRP Length = 239 Score = 132 bits (332), Expect = 2e-29, Method: Composition-based stats. Identities = 62/263 (23%), Positives = 102/263 (38%), Gaps = 30/263 (11%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 N+SFE FP + L I+ L+ KP FVSVT+G + +K I+ + Sbjct: 2 KNISFEIFPCNNIKDLSVL---INYLNKNKPSFVSVTFG-----KINNLKFVKNIQKQIS 53 Query: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASD-LVTLLKE 141 + PHL C + I + + + GD + +Y L + Sbjct: 54 TKIIPHLICDNIFNIINYIIYFIKIKI--FNFLIITGDKNKNNSIKYIYFIRFLFGHI-- 109 Query: 142 VADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSA 201 I Y E H +K+ + ++L +K G N ITQFF++ + + + Sbjct: 110 ---IKIITGCYFENHKFSKNFKNEILFHYKKNKIGTNMCITQFFYNFNTIKYYINIIKKT 166 Query: 202 GIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMV 261 GI I GI+ N K + ++ + IP W+ + + K + V Sbjct: 167 GISKNFILGIISKKNIKDILNYTNLCKIDIPIWIIKNY----------KEFNIELF--FV 214 Query: 262 KILSREGVKDFHFYTLNRAEMSY 284 K L + K+ HFYT N + Sbjct: 215 KNLKKY--KNLHFYTFNNINLIK 235 >UniRef50_C7MDX6 Methylenetetrahydrofolate reductase n=1 Tax=Brachybacterium faecium DSM 4810 RepID=C7MDX6_BRAFD Length = 274 Score = 131 bits (331), Expect = 2e-29, Method: Composition-based stats. Identities = 59/270 (21%), Positives = 94/270 (34%), Gaps = 31/270 (11%) Query: 27 FEFFPPRTSEMEQTLWNSIDRLSSLKPKF--VSVTYGANSGERDRTHSIIKGIKDRTGLE 84 FE P L + + + P V+VT G T + + R G Sbjct: 20 FEVIP---------LRGIAEEVLAQLPAGARVTVTASPAQGLPA-TLEVTCTL-ARHGFC 68 Query: 85 AAPHLTCID-ATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVA 143 A PHL P E+ + G+R + + GD P +G+ E A DL+ +L + Sbjct: 69 AIPHLAARMLRDPGEVAEVLARLGEAGVREVFVIAGDAPHPAGRFEG-ALDLLEVLS-PS 126 Query: 144 DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGI 203 + A+PE HP A L L+ K + A A+TQ F+ L + R GI Sbjct: 127 GMRAGIGAHPEGHPFL-DEAAALSLLRAKAE-HAAYAVTQMSFEAVPLLAWTRRLREEGI 184 Query: 204 DVEIIPGILPVSNFKQAKKFADMTNVRIPAWM--------AQMFDGLDDDAETRKLVGAN 255 + + PGI ++ + + V + ++ D A+ Sbjct: 185 TLPVRPGIAAPASTARLLRIGTRIGVGRSLRLLGADGSGMLRLLGPGQWDPGPLLAQLAS 244 Query: 256 IAMDMVKILSREGVKDFHFYTLNRAEMSYA 285 A + L H YT N + Sbjct: 245 AAAEPGLAL-----HGPHLYTFNAVRAARE 269 >UniRef50_A0L7S2 Methylenetetrahydrofolate reductase n=2 Tax=cellular organisms RepID=A0L7S2_MAGSM Length = 253 Score = 131 bits (331), Expect = 2e-29, Method: Composition-based stats. Identities = 45/254 (17%), Positives = 83/254 (32%), Gaps = 25/254 (9%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 +S E P + L + I R+ P+ ++ R+ + Sbjct: 9 RLSVELVP----RDVEVLKDEIKRVHQHFPQITTINIPDLVRYPIRSWDGC-VLAKDHFS 63 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVA 143 A PHL +D + + NGI ++ + GD P D + +++ Sbjct: 64 SAIPHLRAMDMPEQPILPMLDVLDANGITEVLVISGDEPVAGEV--HRGPDSLEIIQRFK 121 Query: 144 DFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGI 203 + Y + P + Q +L ++K++AGA TQ FFD + D+ Sbjct: 122 TLAPHIKVYAALDPYRTNIQHELAYAQQKLEAGAAGLFTQPFFDHRLMQIYADQLQ---- 177 Query: 204 DVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKI 263 + G+ PV ++ + V PA A +DM+ Sbjct: 178 GCAVWWGLSPVVTEASKNYWSRVNRVVFPASFQADL--------AWNQAFARDVLDMIHE 229 Query: 264 LSREGVKDFHFYTL 277 + H Y + Sbjct: 230 M------GHHIYFM 237 >UniRef50_Q3BYU2 Methylenetetrahydrofolate reductase n=16 Tax=cellular organisms RepID=Q3BYU2_XANC5 Length = 325 Score = 131 bits (329), Expect = 3e-29, Method: Composition-based stats. Identities = 47/280 (16%), Positives = 90/280 (32%), Gaps = 33/280 (11%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 S E +++ L N+ R+ F+ Y + R + G Sbjct: 42 AYSLEV----SAKDIGALTNAAPRILPGCAMFI--PYLPGQNQAVR--LAAAQMVRSLGF 93 Query: 84 EAAPHLTCIDA-TPDELRTIARDY-WNNGIRHIVALRGDLPPGSGKPEMYASDLVT--LL 139 E PHL+ + EL+ G+ + + GD G P + L+ + Sbjct: 94 EPVPHLSARRIGSLGELQACIARLVDEAGVTRCLVIAGDPSTPKG-PFPDSVSLIETGVF 152 Query: 140 KEVADFDISVAAYPEVHPEAKSAQADLLNLKRK----VDAG-ANRAITQFFFDVESYLRF 194 + I+VA +PE HP ++ + L+RK + G A +TQF FD + + + Sbjct: 153 ERSGIRTIAVAGHPEGHPILRTTE-QWEVLERKCRSIQERGMAPLIVTQFGFDADIVVTW 211 Query: 195 RDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQ-------MFDGLDDDAE 247 + + G+ + G+ ++ ++A V A + G Sbjct: 212 LEALRARGMTHPVRVGVPGPASVAVLARYAASCGVGACASVLSNYGISIGKLFGNAGPDR 271 Query: 248 TRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAIC 287 + + + G H + S Sbjct: 272 FVDRLASRLTE-------AHGDVRLHLFPFGGIAQSVEWV 304 >UniRef50_A6EV92 Methylenetetrahydrofolate reductase n=1 Tax=Marinobacter algicola DG893 RepID=A6EV92_9ALTE Length = 309 Score = 131 bits (329), Expect = 3e-29, Method: Composition-based stats. Identities = 46/261 (17%), Positives = 81/261 (31%), Gaps = 23/261 (8%) Query: 44 SIDRLSSLKP--KFVSVTYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDA-TPDELR 100 + + L L P V V + D T + + + G++ PH+ A + +LR Sbjct: 39 AQEHLPDLLPRGTCVYVPFLPKGQFSD-TLRACRHLLNV-GMQPIPHVPARMAESRGQLR 96 Query: 101 TIARDYWNNGIRHIVALRGDLPP-GSGKPEMYASDLVTLLKEVADFDISVAAYPEVHPEA 159 +G+ ++ + GD P+ A LL + I VAA+P+ HP A Sbjct: 97 DWLSQLNESGVDRLLLIAGDSDAIAGPFPDTLAVLESGLLAQFQFHGIGVAAHPDGHPMA 156 Query: 160 KSAQADLLNLKRKVDAGAN-----RAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPV 214 + L K + +TQF FD + + +V + G+ Sbjct: 157 -DRTTLIQALGIKREYARTTSTRLWVVTQFTFDANVVIDWLQSLGDILEEVPVYIGMAGP 215 Query: 215 SNFKQAKKFADMTNVRIPAWMA------QMFDGLDDDAETRKLVGANIAMDMVKILSREG 268 + K +A V A + + + +D L R Sbjct: 216 TRVKTLIAYAAQCGVGASARLMLQRPGSAKLLRAWSPDGMVRAL-VQYCLDNPDTLLR-- 272 Query: 269 VKDFHFYTLNRAEMSYAICHT 289 H + S Sbjct: 273 --GIHLFPFGGLRQSAQWIQE 291 >UniRef50_B8FFI9 Methylenetetrahydrofolate reductase n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FFI9_DESAA Length = 291 Score = 129 bits (325), Expect = 9e-29, Method: Composition-based stats. Identities = 44/306 (14%), Positives = 97/306 (31%), Gaps = 39/306 (12%) Query: 9 RDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERD 68 ++AL++ L V+ E P ++ L N + VS+ G Sbjct: 4 KEALDKKL------FVVTSEVQAPFDENPQELLDNLKQ--IRGRVDGVSIAESDIQGIVG 55 Query: 69 RTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVA------LRGDLP 122 T I + +A T D +L+ + G+ +++ + GD Sbjct: 56 DTVKTC-EILNENRFDAIYQTTTRDKNRIQLQKDLLTAHDAGVENLLVFTEDYRITGDSL 114 Query: 123 PGSGKPEMYASDLVTLLKEVA--------------DFDISVAAYPEVHPEAKSAQADLLN 168 + A L ++LK + +F + E + +L Sbjct: 115 QEMMFFHVDAGKLDSVLKSMREGHSVEGKPLDKRAEFLLGSGV--ESGWGRNVPELELKE 172 Query: 169 LKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTN 228 +++ GA ++ FD++ + +F + + G V +I ++ + A+ Sbjct: 173 MEQMTGVGAGYFLSTPVFDLDLFEKFLKQANTFG--VPVIAELMILRTAGMARFLNRHIR 230 Query: 229 VR-IPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAIC 287 +P W+ + D + + D+ K L H ++ + Sbjct: 231 SGLVPDWVIKKLAQAPDK----QKASIELFADLAKGLKDL-CDGVHIISIGGTDKLKHYL 285 Query: 288 HTLGVR 293 +R Sbjct: 286 DAAKLR 291 >UniRef50_UPI0001C31E0D methylenetetrahydrofolate reductase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31E0D Length = 273 Score = 129 bits (324), Expect = 1e-28, Method: Composition-based stats. Identities = 50/241 (20%), Positives = 91/241 (37%), Gaps = 14/241 (5%) Query: 53 PKFVSVTYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCID-ATPDELRTIARDYWNNGI 111 P +++T G + T ++ + + G PH+ A L T+ GI Sbjct: 22 PVTLTITCSPRLGV-EHTLTVAERARA-LGHRVVPHVAARMVADRSHLDTLMERLAAAGI 79 Query: 112 RHIVALRGDLPPGSGKPEMYASDLVTLLK--EVADFDISVAAYPEVHPEAKSAQADLLNL 169 + + A +L+ L+ E+ I + AYPE HP L Sbjct: 80 DDVFLIG-GDAAAPAGAFDSAVELLPLMHAHELRPRRIGIGAYPEGHPLV-DRATLADAL 137 Query: 170 KRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNV 229 RK A A+ +TQ FD + LR+ ++ +AG+D+ G+ + ++ + + V Sbjct: 138 CRK-AAFADYMVTQLCFDPAALLRWIEQTRAAGVDLPSYVGLPGAVDRRRLLEVSMRVGV 196 Query: 230 RIPAWMAQMFDGL----DDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYA 285 + G+ + +GA A + + ++ HFYT NR + A Sbjct: 197 GDSIGFLRKQRGIRRLLSRPERAVERLGAAFAPLVGE--PELAIEGLHFYTFNRLRATLA 254 Query: 286 I 286 Sbjct: 255 W 255 >UniRef50_A0JQZ4 Methylenetetrahydrofolate reductase n=1 Tax=Arthrobacter sp. FB24 RepID=A0JQZ4_ARTS2 Length = 302 Score = 126 bits (317), Expect = 1e-27, Method: Composition-based stats. Identities = 43/223 (19%), Positives = 67/223 (30%), Gaps = 14/223 (6%) Query: 68 DRTHSIIKGIKDRTGLEAAPHLTCIDAT-PDELRTIARDYWNNGIRHIVALRGDLPPGSG 126 +RT + G PHL EL I RD +GI + + GD +G Sbjct: 40 ERTMRAAVQL-GVLGYSVIPHLAARSVPGRSELTGILRDCDVSGINEVFVIGGDRKQPAG 98 Query: 127 KPEMYASDLVTLLKEVAD--FDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQF 184 P + L+ + + VA YPE HP L L K A+ +TQ Sbjct: 99 -PYASSLPLLEDIAQYTGGRMRAGVAGYPEGHPSVGPVD-LLDALLAKQHL-ASNVVTQM 155 Query: 185 FFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDD 244 F L F G+ + + G+ + A V Sbjct: 156 CFSAPKILDFAALLRREGVQLPVWAGVAGTVPRTKLVSLATQIGVGSSLKFLSR----KG 211 Query: 245 DAETRKLVGANIAMDMVKILSREG---VKDFHFYTLNRAEMSY 284 + L G + + + H Y+ N + + Sbjct: 212 PLARKLLSGDRYSPESLVAGLESPAGIFAGIHLYSFNNLDPAP 254 >UniRef50_A6DQ26 Methylenetetrahydrofolate reductase n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DQ26_9BACT Length = 255 Score = 126 bits (316), Expect = 1e-27, Method: Composition-based stats. Identities = 37/218 (16%), Positives = 68/218 (31%), Gaps = 16/218 (7%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 +S E P + + + + PK +V R+ + Sbjct: 4 ISIELVP----HAAEEITCELKGIQEAFPKVNTVNIPDIVRLPTRSWEACGFCAPMLERD 59 Query: 85 AAPHLTC--IDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEV 142 PHL D + +L + ++ + GD G + D + K Sbjct: 60 -IPHLRACDFDLSKAQLLHDIMAEYK--FDEVLLVGGDFFEGREHFDTSTVDFIKFFKTN 116 Query: 143 ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAG 202 V Y + P + ++ LK K+ G + TQ FFD+E ++ + Sbjct: 117 YP---DVKVYGAIDPYRADFETEMKYLKEKMAVGIDGFFTQPFFDLELLAKWIEALK--- 170 Query: 203 IDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFD 240 D + G+ PV + K + V P + Sbjct: 171 -DQVVYWGLSPVLSAKSQAYWEKRNLVNFPKDFVPELE 207 >UniRef50_D2S7Q5 Methylenetetrahydrofolate reductase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2S7Q5_9ACTO Length = 310 Score = 125 bits (314), Expect = 2e-27, Method: Composition-based stats. Identities = 54/291 (18%), Positives = 95/291 (32%), Gaps = 34/291 (11%) Query: 7 SQRDALNQSLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE 66 R L ++L E S+E P R +E + ++ + P V+VT Sbjct: 29 RSRGTLERALREA------SYEVLPLRGAEA-----SVVEHVPRTVPLTVTVTEAKGLTP 77 Query: 67 RDRTHSIIKGIKDRTGLEAAPHLTCID-ATPDELRTIARDYWNNGIRHIVALRGDLPPGS 125 T + + + G PHL L + + + + GD + Sbjct: 78 ---TLELAERL-SGHGFTVTPHLAARLVHDASHLADVIARLQAAAVDGVFVVGGDAAEPA 133 Query: 126 GKPEMYASDLVTLLKEVADF--DISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQ 183 G A L+ L+ V + + YPE H SA+ L+RK A ITQ Sbjct: 134 GT-FPDALGLLEALETVGHHFRHVGIGGYPEGHGHI-SAELIERALERK-APHATHVITQ 190 Query: 184 FFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQM----- 238 F S + + G+D+ I G+ ++ + + + A Sbjct: 191 LCFHPASTTAWARQVKRRGVDLPIRIGLPGAVTRQKLIRISAGLGLGRSARFLAKQHSMF 250 Query: 239 ---FDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAI 286 F + +A + + ++ FHF+T N + A Sbjct: 251 WRFFLPHGYRPDRLVEG---LAPTLGR--PEHNLQGFHFFTFNEVARTEAW 296 >UniRef50_B6BQ92 Methylenetetrahydrofolate reductase n=2 Tax=Bacteria RepID=B6BQ92_9RICK Length = 255 Score = 125 bits (314), Expect = 2e-27, Method: Composition-based stats. Identities = 43/276 (15%), Positives = 95/276 (34%), Gaps = 31/276 (11%) Query: 15 SLAEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSII 74 + ++ ++N S E P +T ++ L +K +V++ ++ + I Sbjct: 6 NKIMIEKKMNFSLEIGP-KTD---------LETLPPVKDVYVTM--LPGGDYKETSDQSI 53 Query: 75 KGIKDRTGLEAAPHLTCIDA-TPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS 133 + +K G PH EL+ + G++ + + G P + Sbjct: 54 ELVKK--GFNPVPHFPARSIENDSELKDYVSRCKDGGVKQALIIGGGREPMG--KFDSSF 109 Query: 134 DLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLR 193 L+ + I +A +PE P+ D + +K A+ +TQ+ D + + Sbjct: 110 QLLE-TGYFENMKIGIAGHPEGSPDISDTDLDKAMMDKKP--YADYIVTQWLLDPQPIID 166 Query: 194 FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVG 253 F + V + GI KFA++ + + + ++ L+ Sbjct: 167 FISK-----QSVPVHVGITGPLKISSLIKFANIVGAKNSLNFLK-----SNFSKALDLLK 216 Query: 254 ANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHT 289 D++ + +FH YT + + Sbjct: 217 PKDPNDLIGKVKSHT-DNFHIYTFGGLKETNKWLKE 251 >UniRef50_B0VPR6 Methylenetetrahydrofolate reductase n=15 Tax=Acinetobacter RepID=B0VPR6_ACIBS Length = 470 Score = 124 bits (312), Expect = 4e-27, Method: Composition-based stats. Identities = 47/273 (17%), Positives = 93/273 (34%), Gaps = 22/273 (8%) Query: 19 VQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIK 78 Q Q V E+ ++ + P +++ +S K Sbjct: 15 QQNQFFVLVEYL-----TSLHEIYPVRHEFAGY-PAAMTLADRVHSDHDIAPLEASKSYP 68 Query: 79 DRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG-----SGKPEMYAS 133 D +E H + + + I++++ L GD G+P Sbjct: 69 D--SIEKVLHFSGKARDIQDFERFLEQAKSANIQNLLLLTGDKLKEHHNGRDGQPRSRYL 126 Query: 134 DLVTLL---KEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVES 190 + V + K+ F I VA P + EA+ A L L +K+ AGA+ ITQ +D+E+ Sbjct: 127 ESVNAVMAAKQHGGFRIGVAFNPFKYVEAE-RDAQYLKLHKKIKAGADFIITQLGYDIEA 185 Query: 191 YLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKF--ADMTNVRIPAWMAQMFDGLDDDAET 248 + + +I+ ++P++ +A + + I M ++ T Sbjct: 186 LKQAKSFLTKHDYSQQILACVMPLT-LGRANFMVKHKVAGIVITPHMLKVLAEEKQTGHT 244 Query: 249 RKLVGANIAMDMVKILSREGVKDFHFYTLNRAE 281 ++ + I G H ++ E Sbjct: 245 DRVYL--RCALQILICKHLGFAGIHLSACHKPE 275 >UniRef50_A4TRX0 Methylenetetrahydrofolate reductase n=1 Tax=Yersinia pestis Pestoides F RepID=A4TRX0_YERPP Length = 187 Score = 124 bits (311), Expect = 5e-27, Method: Composition-based stats. Identities = 41/193 (21%), Positives = 77/193 (39%), Gaps = 12/193 (6%) Query: 101 TIARDYWNNGIRHIVALRGDLPP-GSGKPEMYASDLVTLLKEVAD-FDISVAAYPEVHPE 158 I Y N GI +RGD P Y +L+ L++ I + YP+ H E Sbjct: 2 QIIEKYINVGICEFFVIRGDKHVYDQDNPINYGVELIELIRRSHKHIGIKTSLYPDFHKE 61 Query: 159 AKSAQADLLNLKRKVDAGANRAITQFFFDVESY---LRFRDRCVSAGIDVEIIPGILPVS 215 + ++ +RK G N I+Q + + + D+ P I+P+ Sbjct: 62 TTEVKEEIDWNERKYQLGVNEFISQLTLNTNALDFLSHWVDKER------PFTPSIMPLG 115 Query: 216 NFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFY 275 NF +KF ++ P W+ + + + E ++ +G I + + + + H + Sbjct: 116 NFSFIEKFTSSNSIDYPLWIKKFANSKSNSNEDKENIGIEIIRFLCREYLNQRER-LHVF 174 Query: 276 TLNRAEMSYAICH 288 TLN+ ++ I Sbjct: 175 TLNKVDVMKKIFQ 187 >UniRef50_C8N7U0 Methylenetetrahydrofolate reductase n=1 Tax=Cardiobacterium hominis ATCC 15826 RepID=C8N7U0_9GAMM Length = 296 Score = 123 bits (308), Expect = 1e-26, Method: Composition-based stats. Identities = 50/284 (17%), Positives = 92/284 (32%), Gaps = 36/284 (12%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKP-----KFVSVTYGANSGERDRTHSIIKGIKD 79 S E P + ++ +P V V + + +++ Sbjct: 15 YSIEITP-----------KAAQKIGDFRPWLTEGTQVYVP-NLRGTKISDCIDTCELLQN 62 Query: 80 RTGLEAAPHLTCID-ATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTL 138 + + A PH+ + + DELR GI I+ L G G + S L T Sbjct: 63 Q-HMCAVPHIVLRNYRSEDELRQTLDRVQALGIDRILLLAGAASQPLGPYDSVMSMLKTG 121 Query: 139 LKEVADF-DISVAAYPEVHPEAKSAQADLLNLKRKVDA----GANRAITQFFFDVESYLR 193 L + F I A +PE + A + +++ A G ITQF F + Sbjct: 122 LLQHYRFAHIGFAGHPEGAADIPRADQEAAEAQKQGYALTYPGDYAFITQFCFQMPPIAA 181 Query: 194 FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVG 253 + + + I + + GI V++ + + A + + RKL+ Sbjct: 182 WLEHLQARQITLPVHIGIPGVASLQSLLRHAQACGIGSSMSFL-----WKNARNVRKLMS 236 Query: 254 ANIAMDMVKILSREGVKD-------FHFYTLNRAEMSYAICHTL 290 + ++ L+ HFY L E + + Sbjct: 237 LSTPDKLLCDLAAHRRDHPDSALRQLHFYPLGGFETTINWLRAI 280 >UniRef50_C9YXB3 Putative uncharacterized protein n=2 Tax=Actinomycetales RepID=C9YXB3_STRSW Length = 278 Score = 121 bits (305), Expect = 2e-26, Method: Composition-based stats. Identities = 44/278 (15%), Positives = 80/278 (28%), Gaps = 26/278 (9%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 V +E P + E+ L + + V+VT G + T + + G Sbjct: 11 RTVRYEVLPA-GATEEKVLAHVPRDV------VVTVTASPVKGL-EPTLDLTGRLAA-HG 61 Query: 83 LEAAPHLTCID-ATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKE 141 PH+ L+ + G+ + GD P +G + L L + Sbjct: 62 YRVVPHVPARLLRDDRHLKEVVDRLREAGVDDVFVPAGDADPPAGPYDGALPVLRRLSEL 121 Query: 142 VADF-DISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVS 200 F + V YPE HP + + K + A ++ FD + R Sbjct: 122 GGPFARVGVTGYPESHPLIHD-DVTVQAMWDKRE-HATYLVSNLCFDPRVLGEWLARVRR 179 Query: 201 AGIDVEIIPGILPVSNFKQAKKFADMTNVRIP--------AWMAQMFDGLDDDAETRKLV 252 + + + G+ + A V +W + E Sbjct: 180 RDVTLPVHVGVAGPVQRAKLLSMATKIGVGESTRFLTRHASWFVRFAAPGGYSPEKLLTR 239 Query: 253 GANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTL 290 + GV H +T N+ + +L Sbjct: 240 -----TEKALTDPASGVAGLHLFTFNQIAETERWRRSL 272 >UniRef50_C7JBE9 Methylenetetrahydrofolate reductase n=10 Tax=Acetobacteraceae RepID=C7JBE9_ACEP3 Length = 249 Score = 121 bits (303), Expect = 4e-26, Method: Composition-based stats. Identities = 36/219 (16%), Positives = 73/219 (33%), Gaps = 15/219 (6%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 +S E P + L + + + P ++ R+ ++ + G Sbjct: 5 RLSVELIP----RSAEALAADVATVKAAFPAADTLNIPDLMRFPLRSWDAAALVRPQFG- 59 Query: 84 EAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKP-EMYASDLVTLLKEV 142 PH+ ID G+ I+ + GD P +++ + ++ Sbjct: 60 NVIPHIRAID---IAPDAPLPGADQPGLEEILVVHGDPPADLSHRTYPNSTESI--IRRY 114 Query: 143 ADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAG 202 + Y P ++ +L ++ RK +AGA TQ FD++ + D C Sbjct: 115 RREAPHLKVYAAFDPYRRAPWKELEDVARKKEAGAIGFFTQPVFDLKLF----DLCREWM 170 Query: 203 IDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDG 241 + G+ PV K + ++ P + D Sbjct: 171 QGECVFWGLSPVIGPKSRSYWETTNHIVFPRDFSPTLDA 209 >UniRef50_A6DQ44 Methylenetetrahydrofolate reductase n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DQ44_9BACT Length = 487 Score = 120 bits (301), Expect = 7e-26, Method: Composition-based stats. Identities = 38/265 (14%), Positives = 80/265 (30%), Gaps = 13/265 (4%) Query: 21 GQINVSFEFFPPRTSEMEQ----TLWNSIDRLSSLK-PKFVSVTYGANSGERDRTHSIIK 75 G+ +V E PP E + +L + S + ++V + + Sbjct: 25 GKFSVVVEVAPPLEGEGDSDNMFSLEKIAEECSRHEEIVGIAVNDRIQGPTHIPAWKLAQ 84 Query: 76 GIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDL 135 + + A H++ + + GI +++ + G L G K L Sbjct: 85 RLSKISTKPAISHISGQGHDQESFEEEVAAASSAGINNLLLISGTLQEGEEKYFESTEQL 144 Query: 136 VTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFR 195 + + + A P + S A L + +K+ +GA TQ D+ Y Sbjct: 145 RNCTAKHENINTGAAVNPFKYSVNSSF-AQYLKMIQKISSGAKFITTQAGLDMRKYDELL 203 Query: 196 DRCVSAGIDVEIIPGILPVS--NFKQAKKFADMTNVRIPAWM----AQMFDGLDDDAETR 249 C I V +I + +S V + + + + D + Sbjct: 204 RFCTHREITVPLIARLNLISHDCLPMITDLQMEPGVPLSREISSLVLRELNEAQDHSSFM 263 Query: 250 KLVGANIAMDMVKILSREGVKDFHF 274 + + + + + G Sbjct: 264 NIQLRRLCL-QINACALMGYSGVQI 287 >UniRef50_A6VT58 Methylenetetrahydrofolate reductase n=1 Tax=Marinomonas sp. MWYL1 RepID=A6VT58_MARMS Length = 274 Score = 118 bits (295), Expect = 3e-25, Method: Composition-based stats. Identities = 54/267 (20%), Positives = 98/267 (36%), Gaps = 24/267 (8%) Query: 23 INVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTG 82 S E T++ L++ L P V++ + N R ++ G Sbjct: 6 PKFSLET----TAKSINELFSVASILPPNTP--VNIAFLGNESHEQRVNAAASI--RALG 57 Query: 83 LEAAPHLTCID-ATPDELRTIARDYWNNG-IRHIVALRGDLPPGSGKPEMYASDLVT--L 138 LE P ++ + +L + + + I+ + GD G P + +L+ + Sbjct: 58 LEPTPIISSRRIKSKADLDYFLGELMAHSKNKRIMLVGGDPEVPEG-PYESSLELLKSDI 116 Query: 139 LKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANR-----AITQFFFDVESYLR 193 LK + +A YPE HP+ S + +LK KVD TQ F + +R Sbjct: 117 LKTCDVESVVIAGYPEGHPKIAS-HQLISSLKWKVDYLREHQFKVEITTQLAFCAANIIR 175 Query: 194 FRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDG---LDDDAETRK 250 + + GI I G+ + K + FA + V I ++ Sbjct: 176 WVQEVRAMGIVEPIRIGVPCPTRVKTLRHFAKLFGVYISEASFVKYEMNTIYQQLDAKTD 235 Query: 251 LVGANIAMDMVKILSREGVKDFHFYTL 277 + + + ++ L+ E + FH YTL Sbjct: 236 TLYLEL-VQQIESLAIENIY-FHLYTL 260 >UniRef50_Q4W2U7 Methylenetetrahydrofolate reductase n=1 Tax=Rhodobacteraceae bacterium 179 RepID=Q4W2U7_9RHOB Length = 286 Score = 117 bits (293), Expect = 6e-25, Method: Composition-based stats. Identities = 56/272 (20%), Positives = 99/272 (36%), Gaps = 21/272 (7%) Query: 25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLE 84 S E P EM Q L F++ K + G Sbjct: 21 FSIELSP----EMVQKFDPDPTSLPPGSKVFLT---HITGKNPQTQIDAAKQLLS-MGYV 72 Query: 85 AAPHLTCIDA-TPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTL--LKE 141 H+ + + +E + + + +NG+ H + L G+ +G P A DL+T L + Sbjct: 73 PVVHMGARNFESDEEFVRLVQAHSDNGVTHGLFLGGNPLKHNG-PLHEAMDLLTHDVLPD 131 Query: 142 VADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRA------ITQFFFDVESYLRFR 195 + YPE HP+ +AQ + K+K++A N I+QF FD ++ + Sbjct: 132 TCMTHAFIGGYPEGHPDIDTAQLENAR-KQKLEA-CNAIGLKPEIISQFAFDGDTMAAWA 189 Query: 196 DRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGAN 255 + DV I G+ V++ + KFA M V + + G + + G + Sbjct: 190 TKMSQEEPDVPIRLGLAGVTSLHKLIKFAVMCGVGPSIAVLKKNAGGLMKVMSDRDPG-D 248 Query: 256 IAMDMVKILSREGVKDFHFYTLNRAEMSYAIC 287 I + E + HF+ + + Sbjct: 249 IVEKIEHRYFGENSLNVHFFPFGGWKKTLDWV 280 >UniRef50_Q1AXZ5 Methylenetetrahydrofolate reductase n=2 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1AXZ5_RUBXD Length = 324 Score = 116 bits (292), Expect = 6e-25, Method: Composition-based stats. Identities = 54/296 (18%), Positives = 94/296 (31%), Gaps = 35/296 (11%) Query: 27 FEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG---ERDRTHSIIKGIKDRTGL 83 +E P +E W R K +++T G T + + R G Sbjct: 16 YEVIPLAGTEEAVERWLISRRAEEQKKTTITITASPTRGIEPTIALTERLGAKARRRGGE 75 Query: 84 E----AAPHLTCIDA-TPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTL 138 PHL+ L I G+ + + GD G+ L L Sbjct: 76 PSSLCVVPHLSARLIEDEHHLEEIVARLKEAGVEEVFVIGGDAKEPRGRFHDALGLLEAL 135 Query: 139 LKEVADF-DISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDR 197 + F + +A YPE HP + +A+L RK A+ ++Q F+ + L + R Sbjct: 136 EELGRPFERVGIAGYPEGHPSIE--RAELERALRKKALYASYVVSQLCFEAKKVLLWARR 193 Query: 198 CVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQM-----FDGLDDDAETRKLV 252 G+ + ++ G+ + K+ A + A + L R + Sbjct: 194 VRELGVGLPVVVGVAAPIDPKRLAGVAAKIGIGDSARFLRKQRAKSLLRLLSPGRRRSAL 253 Query: 253 GANI-----AMDMVKILSREG--------------VKDFHFYTLNRAEMSYAICHT 289 ++V+ SREG + H YT N + + Sbjct: 254 SLVYEPGGFLEELVEEGSREGLLASSGGTEEGGGMISGLHLYTFNDLQRTLEWVRE 309 >UniRef50_Q92XS4 Methylenetetrahydrofolate reductase n=2 Tax=Rhizobiales RepID=Q92XS4_RHIME Length = 317 Score = 116 bits (292), Expect = 8e-25, Method: Composition-based stats. Identities = 55/277 (19%), Positives = 93/277 (33%), Gaps = 28/277 (10%) Query: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGL 83 +S E P E + D L+ F++ I G Sbjct: 42 TISIELAP----EQVRNFAPQADTLALGSRVFLT---HLAGKPEVLQVEAAARI-IEMGY 93 Query: 84 EAAPHLTCID-ATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTL--LK 140 A PHL + + + + + NGI ++ L G P P +++L+ L Sbjct: 94 VAVPHLAARNFKSERDYISHVEAHSRNGIDEVLFLGG-NPALFPGPLGESAELLAHPVLS 152 Query: 141 EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANR-----AITQFFFDVESYLRFR 195 + + VA YPE HP S LKRK++ A R ++QF FD + Sbjct: 153 DSSIRTAFVAGYPEGHPNI-SEARLKDALKRKLEICARRSLEPRIVSQFAFDGAMIGAWA 211 Query: 196 DRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGAN 255 R +V I G+ V++ + +FA M V + + +V Sbjct: 212 KRLHDDFPEVPIHVGLAGVTSLTKLIRFAAMCGVGPSIAALRR-----SVSGLLNIVADR 266 Query: 256 IAMDMVKILSREGVK-----DFHFYTLNRAEMSYAIC 287 D++ +S+ HF+ E + Sbjct: 267 NPADVIDAVSKAYPDTVTPLHLHFFPFGGWEKTLTWL 303 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.315 0.153 0.419 Lambda K H 0.267 0.0467 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 1,817,410,827 Number of Sequences: 3077464 Number of extensions: 76758918 Number of successful extensions: 222392 Number of sequences better than 1.0e-01: 250 Number of HSP's better than 0.1 without gapping: 668 Number of HSP's successfully gapped in prelim test: 149 Number of HSP's that attempted gapping in prelim test: 219577 Number of HSP's gapped (non-prelim): 877 length of query: 296 length of database: 1,040,396,356 effective HSP length: 128 effective length of query: 168 effective length of database: 646,480,964 effective search space: 108608801952 effective search space used: 108608801952 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 93 (40.2 bits)