BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (315 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_Q8XAZ4 Uncharacterized protein yneF n=65 Tax=Enterobact...   644   0.0  
UniRef50_A8A075 Diguanylate cyclase (GGDEF) domain protein n=2 T...   570   e-161
UniRef50_D2TIF8 Putative signal transduction protein n=2 Tax=Ent...   518   e-145
UniRef50_C8QCH2 Diguanylate cyclase n=1 Tax=Pantoea sp. At-9b Re...   249   7e-65
UniRef50_D0FTB2 Conserved uncharacterized protein YneF n=3 Tax=E...   216   6e-55
UniRef50_C6CDM3 Diguanylate cyclase n=1 Tax=Dickeya dadantii Ech...   196   7e-49
UniRef50_B1JAS6 Diguanylate cyclase n=5 Tax=Pseudomonas RepID=B1...   195   1e-48
UniRef50_C6CM30 Diguanylate cyclase n=1 Tax=Dickeya zeae Ech1591...   192   2e-47
UniRef50_D2C311 Diguanylate cyclase n=1 Tax=Dickeya dadantii Ech...   188   2e-46
UniRef50_A8GAZ5 Diguanylate cyclase n=2 Tax=Serratia RepID=A8GAZ...   176   1e-42
UniRef50_A0P392 GGDEF domain protein n=1 Tax=Labrenzia aggregata...   169   1e-40
UniRef50_D0IXN6 Diguanylate cyclase n=2 Tax=Comamonas testostero...   155   2e-36
UniRef50_B7GZC2 Uncharacterized protein yneF n=10 Tax=Acinetobac...   151   3e-35
UniRef50_A8GES9 Diguanylate cyclase n=2 Tax=Serratia RepID=A8GES...   150   4e-35
UniRef50_C3JIZ7 Diguanylate cyclase n=2 Tax=Rhodococcus erythrop...   138   3e-31
UniRef50_C6RK39 Diguanylate cyclase n=2 Tax=Acinetobacter radior...   132   1e-29
UniRef50_C3JRE9 Diguanylate cyclase n=2 Tax=Rhodococcus erythrop...   129   1e-28
UniRef50_C6DKF8 Diguanylate cyclase n=5 Tax=Pectobacterium RepID...   129   1e-28
UniRef50_Q7CZM8 GGDEF family protein n=1 Tax=Agrobacterium tumef...   128   3e-28
UniRef50_A9C2H0 Diguanylate cyclase n=2 Tax=cellular organisms R...   127   4e-28
UniRef50_D0S942 Response regulator n=2 Tax=Acinetobacter RepID=D...   125   1e-27
UniRef50_B1YEE7 Diguanylate cyclase n=1 Tax=Exiguobacterium sibi...   123   7e-27
UniRef50_Q2RNW0 Putative diguanylate cyclase (GGDEF domain) n=1 ...   123   9e-27
UniRef50_Q310L5 Diguanylate cyclase (GGDEF domain) n=2 Tax=Desul...   119   1e-25
UniRef50_B7RWX6 GGDEF domain protein n=1 Tax=marine gamma proteo...   119   2e-25
UniRef50_Q3AFS2 GGDEF domain protein n=1 Tax=Carboxydothermus hy...   117   4e-25
UniRef50_C6BU46 Diguanylate cyclase n=1 Tax=Desulfovibrio salexi...   117   7e-25
UniRef50_A5V9Q8 Diguanylate cyclase n=1 Tax=Sphingomonas wittich...   116   9e-25
UniRef50_Q73IE7 Response regulator/GGDEF domain protein n=20 Tax...   116   1e-24
UniRef50_C4LFT4 Diguanylate cyclase n=1 Tax=Tolumonas auensis DS...   116   1e-24
UniRef50_B5YJX2 Diguanylate cyclase n=1 Tax=Thermodesulfovibrio ...   115   2e-24
UniRef50_Q3IKV1 Putative uncharacterized protein n=2 Tax=Alterom...   115   2e-24
UniRef50_Q486E7 Sensory box/GGDEF domain protein n=2 Tax=Proteob...   115   3e-24
UniRef50_Q15NS8 Diguanylate cyclase/phosphodiesterase with PAS/P...   115   3e-24
UniRef50_C8W1N2 Diguanylate cyclase n=1 Tax=Desulfotomaculum ace...   114   4e-24
UniRef50_C8X007 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   114   5e-24
UniRef50_Q65IC8 GGDEF-domain containing protein n=1 Tax=Bacillus...   114   5e-24
UniRef50_D1U9C4 Diguanylate cyclase n=1 Tax=Desulfovibrio aespoe...   114   5e-24
UniRef50_A8H0B9 Diguanylate cyclase and serine/threonine protein...   114   6e-24
UniRef50_Q47C76 PAS:GGDEF n=1 Tax=Dechloromonas aromatica RCB Re...   114   7e-24
UniRef50_Q0A9X2 Diguanylate cyclase n=3 Tax=Proteobacteria RepID...   113   7e-24
UniRef50_A4JKJ0 Diguanylate cyclase n=2 Tax=Burkholderia RepID=A...   113   8e-24
UniRef50_Q4KDW8 GGDEF domain protein n=6 Tax=Pseudomonas RepID=Q...   113   9e-24
UniRef50_C4KYJ1 Diguanylate cyclase n=1 Tax=Exiguobacterium sp. ...   113   9e-24
UniRef50_Q314F9 Diguanylate cyclase (GGDEF domain) n=1 Tax=Desul...   113   9e-24
UniRef50_A3WKT4 GGDEF domain protein n=2 Tax=Alteromonadales Rep...   113   1e-23
UniRef50_A5P728 GGDEF domain protein n=1 Tax=Erythrobacter sp. S...   112   1e-23
UniRef50_C7LC06 GGDEF domain protein n=28 Tax=Brucella RepID=C7L...   112   1e-23
UniRef50_B3R1Q4 Putative di-guanylate cyclase, GGDEF domain; tra...   112   1e-23
UniRef50_A1ASG6 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   112   2e-23
UniRef50_B5ZNS2 Diguanylate cyclase n=10 Tax=Rhizobiales RepID=B...   112   2e-23
UniRef50_Q3SFG4 Putative diguanylate cyclase (GGDEF domain) n=1 ...   112   2e-23
UniRef50_Q21ED1 GGDEF domain n=1 Tax=Saccharophagus degradans 2-...   111   3e-23
UniRef50_A6W0K6 Diguanylate cyclase n=1 Tax=Marinomonas sp. MWYL...   111   4e-23
UniRef50_A4JR79 Diguanylate cyclase with PAS/PAC sensor n=4 Tax=...   110   5e-23
UniRef50_Q1LBF9 Diguanylate cyclase n=1 Tax=Cupriavidus metallid...   110   5e-23
UniRef50_Q1N653 Putative uncharacterized protein n=1 Tax=Bermane...   110   5e-23
UniRef50_A4BIU7 Response regulator containing a CheY-like receiv...   110   5e-23
UniRef50_C6DJJ8 Diguanylate cyclase n=1 Tax=Pectobacterium carot...   110   6e-23
UniRef50_A6X0V6 Diguanylate cyclase n=3 Tax=Brucellaceae RepID=A...   110   6e-23
UniRef50_UPI0001787F83 diguanylate cyclase with PAS/PAC sensor n...   110   6e-23
UniRef50_B6BJC6 GGDEF domain/pas/pac sensor domain protein n=1 T...   110   7e-23
UniRef50_A4BG19 GGDEF domain protein n=1 Tax=Reinekea blandensis...   110   8e-23
UniRef50_Q0K903 GGDEF domain protein n=3 Tax=Cupriavidus RepID=Q...   110   8e-23
UniRef50_B5ZQ84 Diguanylate cyclase n=5 Tax=Rhizobium RepID=B5ZQ...   110   9e-23
UniRef50_A4SQK1 GGDEF domain protein n=2 Tax=Aeromonas RepID=A4S...   109   1e-22
UniRef50_A6F836 Putative uncharacterized protein n=1 Tax=Moritel...   109   1e-22
UniRef50_C7R6Y0 Diguanylate cyclase n=1 Tax=Kangiella koreensis ...   109   1e-22
UniRef50_A1T013 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   109   1e-22
UniRef50_C0QSJ8 Diguanylate cyclase/phosphodiesterase n=1 Tax=Pe...   109   1e-22
UniRef50_D2R798 Diguanylate cyclase n=1 Tax=Pirellula staleyi DS...   109   1e-22
UniRef50_B9JVD4 GGDEF family protein n=1 Tax=Agrobacterium vitis...   109   1e-22
UniRef50_D0LIN2 Diguanylate cyclase n=1 Tax=Haliangium ochraceum...   109   1e-22
UniRef50_Q88RK0 GGDEF domain protein n=3 Tax=Pseudomonas putida ...   109   1e-22
UniRef50_A6UB49 Diguanylate cyclase n=2 Tax=Sinorhizobium RepID=...   109   1e-22
UniRef50_C7LVZ4 Diguanylate cyclase n=1 Tax=Desulfomicrobium bac...   109   1e-22
UniRef50_A6F6I7 Hypothetical GGDEF domain family protein n=1 Tax...   109   1e-22
UniRef50_A6SZ23 Uncharacterized conserved protein n=1 Tax=Janthi...   109   1e-22
UniRef50_Q47X90 GGDEF domain protein n=1 Tax=Colwellia psychrery...   108   2e-22
UniRef50_Q2RRD4 Putative diguanylate cyclase (GGDEF domain) n=1 ...   108   2e-22
UniRef50_B7GHV8 Signal transduction diguanylate cyclase n=1 Tax=...   108   2e-22
UniRef50_Q1MYJ5 Response regulator containing a CheY-like receiv...   108   2e-22
UniRef50_Q1N175 Diguanylate cyclase (GGDEF domain) n=1 Tax=Berma...   108   2e-22
UniRef50_A0LAY9 Diguanylate cyclase n=1 Tax=Magnetococcus sp. MC...   108   2e-22
UniRef50_B0TJ24 Periplasmic/7TM domain sensor diguanylate cyclas...   108   2e-22
UniRef50_Q7MRL2 Putative uncharacterized protein n=1 Tax=Wolinel...   108   3e-22
UniRef50_B5JSY0 Response regulator PleD n=1 Tax=gamma proteobact...   108   3e-22
UniRef50_A6VWF8 Diguanylate cyclase n=1 Tax=Marinomonas sp. MWYL...   108   3e-22
UniRef50_Q47W79 GGDEF domain protein n=1 Tax=Colwellia psychrery...   108   3e-22
UniRef50_Q1K1S4 Diguanylate cyclase n=4 Tax=Bacteria RepID=Q1K1S...   108   3e-22
UniRef50_C4WGI0 Diguanylate cyclase (GGDEF) domain-containing pr...   108   3e-22
UniRef50_B2V685 Diguanylate cyclase/phosphodiesterase n=3 Tax=Su...   108   3e-22
UniRef50_B9L727 Diguanylate cyclase/phosphodiesterase n=1 Tax=Na...   108   4e-22
UniRef50_Q1N3P2 Probable two-component response regulator n=1 Ta...   108   4e-22
UniRef50_Q1D632 GAF domain/GGDEF domain protein n=2 Tax=Cystobac...   107   4e-22
UniRef50_A4XQ87 Diguanylate cyclase n=1 Tax=Pseudomonas mendocin...   107   4e-22
UniRef50_Q1DC46 FHA domain/GGDEF domain protein n=2 Tax=Myxococc...   107   4e-22
UniRef50_C1DD63 Sensor protein n=1 Tax=Laribacter hongkongensis ...   107   4e-22
UniRef50_Q315M6 Diguanylate cyclase n=1 Tax=Desulfovibrio desulf...   107   4e-22
UniRef50_C9YC42 Putative uncharacterized protein n=1 Tax=Curviba...   107   4e-22
UniRef50_Q89SS4 Bll2326 protein n=1 Tax=Bradyrhizobium japonicum...   107   4e-22
UniRef50_Q1LIC9 Diguanylate cyclase (GGDEF domain) n=1 Tax=Cupri...   107   4e-22
UniRef50_Q02P32 Putative two-component response regulator n=6 Ta...   107   4e-22
UniRef50_A9DAY4 Periplasmic sensor diguanylate cyclase n=1 Tax=H...   107   4e-22
UniRef50_B1Z9Z6 Diguanylate cyclase n=6 Tax=Alphaproteobacteria ...   107   5e-22
UniRef50_B2JUD5 Diguanylate cyclase n=4 Tax=Burkholderia RepID=B...   107   5e-22
UniRef50_Q1K433 Ammonium transporter n=1 Tax=Desulfuromonas acet...   107   5e-22
UniRef50_Q1MZ89 Response regulator containing a CheY-like receiv...   107   6e-22
UniRef50_Q5LPK8 GGDEF domain protein n=1 Tax=Ruegeria pomeroyi R...   107   6e-22
UniRef50_Q12S41 GGDEF domain n=1 Tax=Shewanella denitrificans OS...   107   6e-22
UniRef50_Q085X7 Diguanylate cyclase n=2 Tax=Alteromonadales RepI...   107   6e-22
UniRef50_A4BD76 GGDEF domain protein n=1 Tax=Reinekea blandensis...   107   6e-22
UniRef50_A6W1T4 Diguanylate cyclase n=1 Tax=Marinomonas sp. MWYL...   107   6e-22
UniRef50_A1SVZ1 Diguanylate cyclase n=1 Tax=Psychromonas ingraha...   107   6e-22
UniRef50_A3DHG2 Diguanylate cyclase with GAF sensor n=3 Tax=Clos...   107   6e-22
UniRef50_D0LHJ8 Diguanylate cyclase n=1 Tax=Haliangium ochraceum...   107   7e-22
UniRef50_Q2S9K6 Response regulator containing a CheY-like receiv...   107   7e-22
UniRef50_A9AYQ2 Diguanylate cyclase and serine/threonine protein...   107   7e-22
UniRef50_A6WV43 Diguanylate cyclase n=1 Tax=Ochrobactrum anthrop...   107   7e-22
UniRef50_A1SY47 Diguanylate cyclase n=1 Tax=Psychromonas ingraha...   106   9e-22
UniRef50_A3J836 Putative diguanylate cyclase (GGDEF domain) n=1 ...   106   9e-22
UniRef50_A3Y5H4 Diguanylate cyclase (GGDEF domain) n=1 Tax=Marin...   106   9e-22
UniRef50_A6X7T2 Diguanylate cyclase n=1 Tax=Ochrobactrum anthrop...   106   1e-21
UniRef50_Q2SNU2 Response regulator containing a CheY-like receiv...   106   1e-21
UniRef50_Q2IXE2 Response regulator receiver modulated diguanylat...   106   1e-21
UniRef50_Q07MN8 Diguanylate cyclase n=10 Tax=Bradyrhizobiaceae R...   106   1e-21
UniRef50_A8FU11 Diguanylate cyclase n=9 Tax=Shewanella RepID=A8F...   106   1e-21
UniRef50_A6TMF8 Diguanylate cyclase n=1 Tax=Alkaliphilus metalli...   106   1e-21
UniRef50_A1VA66 Diguanylate cyclase with PAS/PAC sensor n=3 Tax=...   106   1e-21
UniRef50_Q2BLA2 Putative uncharacterized protein n=1 Tax=Neptuni...   106   1e-21
UniRef50_B0TH60 Ggdef domain protein, putative n=1 Tax=Heliobact...   106   1e-21
UniRef50_C8Q7A8 Diguanylate cyclase n=1 Tax=Pantoea sp. At-9b Re...   106   1e-21
UniRef50_A8UUF5 Diguanylate cyclase (GGDEF domain) n=1 Tax=Hydro...   106   1e-21
UniRef50_P54595 Uncharacterized protein yhcK n=2 Tax=Bacillus su...   106   1e-21
UniRef50_A8FZ07 Diguanylate cyclase n=2 Tax=Shewanella RepID=A8F...   106   1e-21
UniRef50_Q3A271 Sensor histidine kinase/FOG: GGDEF domain protei...   105   1e-21
UniRef50_A6CY69 Putative GGDEF family protein n=1 Tax=Vibrio shi...   105   1e-21
UniRef50_C6BW86 Diguanylate cyclase n=1 Tax=Desulfovibrio salexi...   105   2e-21
UniRef50_UPI000185121C diguanylate cyclase n=1 Tax=Bacillus coah...   105   2e-21
UniRef50_Q2JA03 Diguanylate cyclase (GGDEF domain) n=1 Tax=Frank...   105   2e-21
UniRef50_Q9RRJ2 GGDEF family protein n=1 Tax=Deinococcus radiodu...   105   2e-21
UniRef50_A1RG31 Diguanylate cyclase n=3 Tax=Shewanella RepID=A1R...   105   2e-21
UniRef50_Q7CXW5 GGDEF family protein n=1 Tax=Agrobacterium tumef...   105   2e-21
UniRef50_B5ZEJ8 Diguanylate cyclase n=2 Tax=Gluconacetobacter di...   105   2e-21
UniRef50_B9ZP75 Diguanylate cyclase n=3 Tax=Thioalkalivibrio sp....   105   2e-21
UniRef50_A8FBD0 ABC superfamily ATP binding cassette transporter...   105   2e-21
UniRef50_C1DCL4 Diguanylate cyclase n=1 Tax=Laribacter hongkonge...   105   2e-21
UniRef50_Q15V65 Diguanylate cyclase n=1 Tax=Pseudoalteromonas at...   105   2e-21
UniRef50_B0UJW4 Diguanylate cyclase n=1 Tax=Methylobacterium sp....   105   2e-21
UniRef50_A4TZG0 GGDEF n=1 Tax=Magnetospirillum gryphiswaldense R...   105   2e-21
UniRef50_Q6AL41 Putative uncharacterized protein n=1 Tax=Desulfo...   105   2e-21
UniRef50_Q0KEL5 Putative uncharacterized protein h16_A0406 n=2 T...   105   2e-21
UniRef50_A0YPS9 Putative uncharacterized protein n=1 Tax=Lyngbya...   105   2e-21
UniRef50_Q2LS38 Response regulator protein with GGDEF domain n=2...   105   2e-21
UniRef50_B9QWG6 GGDEF domain protein n=1 Tax=Labrenzia alexandri...   105   2e-21
UniRef50_A8MM09 Diguanylate cyclase n=2 Tax=Clostridiaceae RepID...   105   3e-21
UniRef50_B8KAR8 Ggdef family protein n=1 Tax=Vibrio parahaemolyt...   105   3e-21
UniRef50_C7RLV2 Response regulator receiver modulated diguanylat...   105   3e-21
UniRef50_B8DJ36 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   105   3e-21
UniRef50_A1VD57 Diguanylate cyclase n=3 Tax=Desulfovibrio vulgar...   105   3e-21
UniRef50_C6MHA0 Periplasmic/7TM domain sensor diguanylate cyclas...   105   3e-21
UniRef50_Q6ALC0 Putative uncharacterized protein n=1 Tax=Desulfo...   105   3e-21
UniRef50_A4CEZ1 Response regulator/GGDEF domain protein n=2 Tax=...   105   3e-21
UniRef50_Q0AQ22 Diguanylate cyclase n=2 Tax=Hyphomonadaceae RepI...   105   3e-21
UniRef50_B8IFL7 Diguanylate cyclase n=1 Tax=Methylobacterium nod...   104   3e-21
UniRef50_Q0AV70 Response regulator receiver protein n=1 Tax=Synt...   104   3e-21
UniRef50_B6BNA8 Diguanylate cyclase/phosphodiesterase with PAS/P...   104   3e-21
UniRef50_Q2BQS0 GGDEF family protein n=1 Tax=Neptuniibacter caes...   104   3e-21
UniRef50_C4WLB9 Diguanylate cyclase (GGDEF) domain-containing pr...   104   3e-21
UniRef50_C6BZK2 Diguanylate cyclase n=1 Tax=Desulfovibrio salexi...   104   3e-21
UniRef50_A4VQQ9 GGDEF domain protein n=1 Tax=Pseudomonas stutzer...   104   4e-21
UniRef50_B3PIC1 Sensory box/GGDEF family protein n=5 Tax=Gammapr...   104   4e-21
UniRef50_B8JB86 Diguanylate cyclase n=4 Tax=Anaeromyxobacter Rep...   104   4e-21
UniRef50_Q21JG3 GGDEF domain n=1 Tax=Saccharophagus degradans 2-...   104   4e-21
UniRef50_B9M798 Diguanylate cyclase n=1 Tax=Geobacter sp. FRC-32...   104   4e-21
UniRef50_Q47Y21 GGDEF domain protein n=1 Tax=Colwellia psychrery...   104   4e-21
UniRef50_Q1YG68 GGDEF domain protein n=1 Tax=Aurantimonas mangan...   104   4e-21
UniRef50_A0Y2V2 GGDEF family protein n=3 Tax=Alteromonadales Rep...   104   4e-21
UniRef50_A6WMZ7 Diguanylate cyclase n=3 Tax=Shewanella baltica R...   104   4e-21
UniRef50_A4Y784 Diguanylate cyclase n=18 Tax=Shewanella RepID=A4...   104   5e-21
UniRef50_A0KEB8 Tetratricopeptide repeat family n=2 Tax=Aeromona...   104   5e-21
UniRef50_C8VW84 Response regulator receiver modulated diguanylat...   103   5e-21
UniRef50_Q2BML0 Putative diguanylate cyclase (GGDEF domain) n=1 ...   103   6e-21
UniRef50_C0QRX3 Diguanylate cyclase/phosphodiesterase n=1 Tax=Pe...   103   6e-21
UniRef50_B8FMG8 Diguanylate cyclase n=1 Tax=Desulfatibacillum al...   103   6e-21
UniRef50_C1M322 Inner membrane protein yeaI n=1 Tax=Citrobacter ...   103   6e-21
UniRef50_A9AXN1 Diguanylate cyclase n=1 Tax=Herpetosiphon aurant...   103   6e-21
UniRef50_C6WY37 Diguanylate cyclase n=1 Tax=Methylotenera mobili...   103   6e-21
UniRef50_C7R8C4 Diguanylate cyclase n=1 Tax=Kangiella koreensis ...   103   6e-21
UniRef50_A0LSI3 Diguanylate cyclase n=1 Tax=Acidothermus cellulo...   103   6e-21
UniRef50_A8FHG3 Possible diguanylate cyclase n=2 Tax=Bacillus pu...   103   6e-21
UniRef50_Q1N6U5 Diguanylate cyclase (GGDEF domain) n=1 Tax=Berma...   103   6e-21
UniRef50_A6VRQ0 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   103   7e-21
UniRef50_A6DDS7 Diguanylate cyclase (GGDEF domain) n=1 Tax=Camin...   103   7e-21
UniRef50_C0N773 GGDEF domain protein n=1 Tax=Methylophaga thioox...   103   7e-21
UniRef50_Q39ZK6 Response regulator receiver modulated diguanylat...   103   7e-21
UniRef50_A6LR61 Diguanylate cyclase n=3 Tax=Clostridium RepID=A6...   103   7e-21
UniRef50_Q5QV72 Intracellular signaling protein (PAS,GAF,GGDEF d...   103   8e-21
UniRef50_Q8D5C1 FOG: GGDEF domain n=1 Tax=Vibrio vulnificus RepI...   103   8e-21
UniRef50_A8H680 Diguanylate cyclase n=2 Tax=Shewanella RepID=A8H...   103   8e-21
UniRef50_A9CEL7 GGDEF family protein n=1 Tax=Agrobacterium tumef...   103   8e-21
UniRef50_B2JTM3 Diguanylate cyclase n=3 Tax=Burkholderia RepID=B...   103   8e-21
UniRef50_A8VUQ7 Response regulator receiver protein n=1 Tax=Baci...   103   8e-21
UniRef50_C9QDN5 Putative uncharacterized protein n=1 Tax=Vibrio ...   103   8e-21
UniRef50_Q1JXC4 Diguanylate cyclase n=1 Tax=Desulfuromonas aceto...   103   9e-21
UniRef50_A9FZW1 FHA domain protein n=1 Tax=Sorangium cellulosum ...   103   9e-21
UniRef50_A8ZXH2 Diguanylate cyclase n=3 Tax=Desulfococcus oleovo...   103   9e-21
UniRef50_D0I9J2 Diguanylate cyclase (GGDEF domain) with PAS/PAC ...   103   9e-21
UniRef50_C7R6L5 Diguanylate cyclase n=4 Tax=Gammaproteobacteria ...   103   1e-20
UniRef50_B8FCK6 Response regulator receiver modulated diguanylat...   103   1e-20
UniRef50_C1A5L7 Putative two-component response regulator n=1 Ta...   103   1e-20
UniRef50_C6NZD9 Diguanylate cyclase/phosphodiesterase with PAS/P...   103   1e-20
UniRef50_A6DDG0 Putative uncharacterized protein n=1 Tax=Caminib...   103   1e-20
UniRef50_Q31IH0 Diguanylate cyclase (GGDEF domain) n=1 Tax=Thiom...   103   1e-20
UniRef50_C7I2H1 Diguanylate cyclase n=1 Tax=Thiomonas intermedia...   103   1e-20
UniRef50_D0SXM5 Predicted protein n=2 Tax=Acinetobacter lwoffii ...   103   1e-20
UniRef50_C6CQG0 Diguanylate cyclase n=7 Tax=Enterobacteriaceae R...   102   1e-20
UniRef50_A3Y6S3 PAS:GGDEF protein n=1 Tax=Marinomonas sp. MED121...   102   1e-20
UniRef50_A9KNZ0 Diguanylate cyclase with GAF sensor n=1 Tax=Clos...   102   1e-20
UniRef50_C6X759 Diguanylate cyclase/phosphodiesterase n=1 Tax=Me...   102   1e-20
UniRef50_Q39S35 Diguanylate cyclase with GAF sensor n=2 Tax=Geob...   102   1e-20
UniRef50_B7KWW4 Diguanylate cyclase n=5 Tax=Methylobacterium Rep...   102   1e-20
UniRef50_C1D6I3 Diguanylate cyclase n=1 Tax=Laribacter hongkonge...   102   1e-20
UniRef50_A7JY97 Ggdef domain protein n=8 Tax=Vibrio RepID=A7JY97...   102   1e-20
UniRef50_Q7CYR0 GGDEF family protein n=4 Tax=Rhizobium/Agrobacte...   102   1e-20
UniRef50_UPI00016C5356 FHA domain protein n=1 Tax=Gemmata obscur...   102   1e-20
UniRef50_C6RM00 Diguanylate cyclase n=5 Tax=Acinetobacter RepID=...   102   1e-20
UniRef50_A7GXF8 3-deoxy-d-manno-octulosonic-acid transferase n=8...   102   1e-20
UniRef50_B9JD30 Sensory box/GGDEF family protein n=12 Tax=Rhizob...   102   1e-20
UniRef50_B8DLP9 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   102   1e-20
UniRef50_Q9KAQ3 Response regulatory protein (Sensory transductio...   102   1e-20
UniRef50_A3WKH9 Serine/threonine kinase with two-component senso...   102   1e-20
UniRef50_Q47FH1 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   102   2e-20
UniRef50_A3QI98 Diguanylate cyclase n=1 Tax=Shewanella loihica P...   102   2e-20
UniRef50_B5JX81 Diguanylate cyclase n=1 Tax=gamma proteobacteriu...   102   2e-20
UniRef50_B9L7P4 Diguanylate cyclase/phosphodiesterase domain 1 n...   102   2e-20
UniRef50_Q2RLY1 Diguanylate cyclase (GGDEF domain) n=1 Tax=Moore...   102   2e-20
UniRef50_C6DCR6 Diguanylate cyclase n=6 Tax=Pectobacterium RepID...   102   2e-20
UniRef50_C8X2S3 Diguanylate cyclase n=1 Tax=Desulfohalobium retb...   102   2e-20
UniRef50_B2A6L1 Response regulator receiver modulated diguanylat...   102   2e-20
UniRef50_A1TWC4 Diguanylate cyclase n=2 Tax=Acidovorax RepID=A1T...   102   2e-20
UniRef50_A8UV88 Putative uncharacterized protein n=1 Tax=Hydroge...   102   2e-20
UniRef50_Q4ZZT3 GGDEF n=5 Tax=Pseudomonas syringae group RepID=Q...   102   2e-20
UniRef50_D1U463 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   102   2e-20
UniRef50_C4XS30 GGDEF domain protein n=1 Tax=Desulfovibrio magne...   102   2e-20
UniRef50_A3WM11 Signaling protein with a sensor domain and GGDEF...   102   2e-20
UniRef50_Q7MFB4 GGDEF family protein n=2 Tax=Vibrio vulnificus R...   102   2e-20
UniRef50_A3SMA4 Diguanylate cyclase, putative/response regulator...   102   2e-20
UniRef50_A8VQE2 Putative diguanylate cyclase n=1 Tax=Bacillus se...   102   2e-20
UniRef50_A0XYM4 Putative uncharacterized protein n=1 Tax=Alterom...   102   3e-20

>UniRef50_Q8XAZ4 Uncharacterized protein yneF n=65 Tax=Enterobacteriaceae
           RepID=YNEF_ECO57
          Length = 315

 Score =  644 bits (1661), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 314/315 (99%), Positives = 314/315 (99%)

Query: 1   MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA 60
           MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA
Sbjct: 1   MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA 60

Query: 61  FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT 120
           FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT
Sbjct: 61  FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT 120

Query: 121 MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL 180
           MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL
Sbjct: 121 MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL 180

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL
Sbjct: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASY TLTDDFNKLMVEADTCLYRSKKD
Sbjct: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKD 300

Query: 301 GRNRTSTMRYGEEVV 315
           GRNRTSTMRYGEEVV
Sbjct: 301 GRNRTSTMRYGEEVV 315


>UniRef50_A8A075 Diguanylate cyclase (GGDEF) domain protein n=2
           Tax=Enterobacteriaceae RepID=A8A075_ECOHS
          Length = 279

 Score =  570 bits (1468), Expect = e-161,   Method: Compositional matrix adjust.
 Identities = 278/279 (99%), Positives = 278/279 (99%)

Query: 37  MMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANS 96
           MMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANS
Sbjct: 1   MMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANS 60

Query: 97  VIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYS 156
           VIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYS
Sbjct: 61  VIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYS 120

Query: 157 RSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKG 216
           RSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKG
Sbjct: 121 RSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKG 180

Query: 217 LVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASY 276
           LVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASY
Sbjct: 181 LVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASY 240

Query: 277 LTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV 315
            TLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
Sbjct: 241 RTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV 279


>UniRef50_D2TIF8 Putative signal transduction protein n=2 Tax=Enterobacteriaceae
           RepID=D2TIF8_CITRO
          Length = 484

 Score =  518 bits (1334), Expect = e-145,   Method: Compositional matrix adjust.
 Identities = 245/306 (80%), Positives = 276/306 (90%)

Query: 1   MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA 60
           + ADWFSEQFSTGVLIVPCMLTL IPG + RF+ EQMMP IALIVSV+ASVVIGGAGSLA
Sbjct: 163 LFADWFSEQFSTGVLIVPCMLTLGIPGSVKRFRPEQMMPVIALIVSVLASVVIGGAGSLA 222

Query: 61  FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT 120
           FPLPALIWCAVRYTPQVTCLLTF+TGAVEIVLVANSVI+I+V SP S PQMFSARLGI T
Sbjct: 223 FPLPALIWCAVRYTPQVTCLLTFLTGAVEIVLVANSVINIAVASPLSAPQMFSARLGIVT 282

Query: 121 MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL 180
           MAICPIMV+FSVAAINSLMKQ++LRADFDFLTQVYSRSGLYEALK  +   +Q++TVMLL
Sbjct: 283 MAICPIMVAFSVAAINSLMKQISLRADFDFLTQVYSRSGLYEALKRQAYPASQNMTVMLL 342

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DIDYFKSINDNYGHECGD+VL VFARHIQ+IVGD+GLVARMGGEEFAV +P+ +P +G+ 
Sbjct: 343 DIDYFKSINDNYGHECGDRVLCVFARHIQRIVGDRGLVARMGGEEFAVVLPTSHPEEGMQ 402

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           +AE IRK V LQPF WQQ+++YLTVSIGVG+G+ +  T+TD FNKLMVEAD CLYRSK +
Sbjct: 403 LAETIRKAVALQPFDWQQQSIYLTVSIGVGNGKIAAQTVTDIFNKLMVEADECLYRSKNE 462

Query: 301 GRNRTS 306
           GRNRTS
Sbjct: 463 GRNRTS 468


>UniRef50_C8QCH2 Diguanylate cyclase n=1 Tax=Pantoea sp. At-9b RepID=C8QCH2_9ENTR
          Length = 474

 Score =  249 bits (637), Expect = 7e-65,   Method: Compositional matrix adjust.
 Identities = 132/308 (42%), Positives = 194/308 (62%), Gaps = 4/308 (1%)

Query: 3   ADWFSEQFSTGVLIVPCMLTLAIPGVLPR--FKAEQMMPAIALIVSVIASVVIGGAGSLA 60
            DWFSEQFST ++++P +L   +  VL R      +++P   +++S+    +IGGAGSL 
Sbjct: 154 GDWFSEQFSTSLMLLPVLLARPLRTVLWRSLLHPGKLLPLTGVVLSLTIGAMIGGAGSLT 213

Query: 61  FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPF-SIPQMFSARLGIA 119
           FP+PALIWCA+     +T L+  +TG  EI+LV++ V++I        I  + S RLG+A
Sbjct: 214 FPVPALIWCAIVLPIPITSLVLLITGITEIILVSHGVMNIQGDDALLPISHLTSVRLGVA 273

Query: 120 TMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVML 179
           T+ I P++V+ S+ AI  L ++++LRA+FDFLTQ+ SRSGLYE L+       +   V++
Sbjct: 274 TITISPLLVAVSMDAIRQLNQRLSLRANFDFLTQLLSRSGLYENLRQEPFSPQRAAGVVM 333

Query: 180 LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGL 239
           LD+DYFK+INDN+GH+ GD VL   AR IQ +V ++GLV R GGEEF V V   N     
Sbjct: 334 LDVDYFKTINDNFGHDAGDGVLEEIARRIQDVVNNRGLVCRFGGEEFVVVVFDYNHSQLY 393

Query: 240 LMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRA-SYLTLTDDFNKLMVEADTCLYRSK 298
            +AE IR+ +  + F  Q  T+ +T S+G+  G A +        N+L+  AD  LY SK
Sbjct: 394 QLAEVIRQSMVREKFWLQGNTVTVTASLGLALGNAVNEREWQGVVNRLISAADKNLYLSK 453

Query: 299 KDGRNRTS 306
           ++GRN+TS
Sbjct: 454 RNGRNQTS 461


>UniRef50_D0FTB2 Conserved uncharacterized protein YneF n=3 Tax=Erwinia
           RepID=D0FTB2_ERWPY
          Length = 464

 Score =  216 bits (551), Expect = 6e-55,   Method: Compositional matrix adjust.
 Identities = 121/311 (38%), Positives = 184/311 (59%), Gaps = 12/311 (3%)

Query: 3   ADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKA----EQMMPAIALIVSVIASVVIGGAGS 58
           + WFSEQ ST +L++P M++L     LP+  A      ++P + LIV++++++ +GG GS
Sbjct: 150 SSWFSEQMSTSILLLPLMISLPRRQQLPQLAAALRDSSVLPLLTLIVTIVSAIWLGGGGS 209

Query: 59  LAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDIS-VGSPFSIPQMFSARLG 117
           L FPLPAL+WCA+ Y   VTC LT +TG  EI+LVA +V++I   G  F I  + SARLG
Sbjct: 210 LLFPLPALLWCAISYPLFVTCFLTMLTGISEIILVAGNVLNIQGKGDLFRIDSLSSARLG 269

Query: 118 IATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHL-- 175
           +A M I P++VS S  +   L+ ++  RAD+DFLT   +RSGL   L S    + +    
Sbjct: 270 VAAMLIGPLIVSLSTLSNKKLVARITRRADYDFLTGALTRSGLSTKLDSLVTGRNRQQGF 329

Query: 176 --TVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSV 233
               +++DID FK IND +GH  GD VL+  A  +++ +    LV RMGGEEF + +  +
Sbjct: 330 IGAALVIDIDRFKDINDTWGHAAGDYVLAKTAECLREGLSPSTLVCRMGGEEFLILIQGM 389

Query: 234 NPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTC 293
                 L+A ++R+ VE     +    L +TVSIG+ S   S +   +  ++ ++ AD  
Sbjct: 390 TQPRSSLLANRLRQNVENNKIIFNGHDLSVTVSIGISSLNISNV---NSLDESIMRADEQ 446

Query: 294 LYRSKKDGRNR 304
           LY +K  GRN+
Sbjct: 447 LYIAKSSGRNQ 457


>UniRef50_C6CDM3 Diguanylate cyclase n=1 Tax=Dickeya dadantii Ech703
           RepID=C6CDM3_DICDC
          Length = 469

 Score =  196 bits (499), Expect = 7e-49,   Method: Compositional matrix adjust.
 Identities = 109/309 (35%), Positives = 177/309 (57%), Gaps = 8/309 (2%)

Query: 4   DWFSEQFSTGVLIVPCMLTL--AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAF 61
           +WFS+QF T VL +P +LT+   I   +P      ++P + L  S+I   +I     LAF
Sbjct: 160 NWFSDQFYTSVLFLPLLLTVRSNIRLRIPALNFNDILPILFLAASLIVGAMISPLAILAF 219

Query: 62  PLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVG--SPFSIPQMFSARLGIA 119
           PLPAL WCA+ Y   +T L+T  TG +++++ A  V  I  G    F+  Q+   R+ IA
Sbjct: 220 PLPALTWCAIVYPLWLTRLITLCTGTLQLIVSAEHVYAIYSGLHDEFT-NQVVITRISIA 278

Query: 120 TMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LT 176
            +   P+ ++ +   I  L K++ L+A +DFLT   SR G  EAL +   ++      + 
Sbjct: 279 AIIFSPLFMAMNAKTIRLLNKRLLLQASYDFLTNTLSRYGFNEALTNYGKEERYRNVSVN 338

Query: 177 VMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPV 236
           +ML+DID+FK IND++GH+CGD+VL   A  I+  + ++GL++R+GGEEFAV     +P 
Sbjct: 339 IMLIDIDHFKHINDSFGHDCGDEVLKQVAAIIKDTINEQGLISRIGGEEFAVVCFDYSPD 398

Query: 237 DGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYR 296
               +A+K+R+ +    F + Q  + + +SIG+    +    L +  ++L  +AD  LY 
Sbjct: 399 AFYWLADKLRRRIYETTFMFNQSPVPVAISIGLAHASSPNGDLLNTVHQLCTQADKNLYA 458

Query: 297 SKKDGRNRT 305
           +K+ GRN+T
Sbjct: 459 AKRQGRNQT 467


>UniRef50_B1JAS6 Diguanylate cyclase n=5 Tax=Pseudomonas RepID=B1JAS6_PSEPW
          Length = 469

 Score =  195 bits (496), Expect = 1e-48,   Method: Compositional matrix adjust.
 Identities = 124/321 (38%), Positives = 179/321 (55%), Gaps = 14/321 (4%)

Query: 5   WFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIA--SVVIGGAGSLAFP 62
           WFSEQFST VL++P +LT      L R  A+ +  A  L++      S+  GG G++AFP
Sbjct: 153 WFSEQFSTAVLLLPVLLTAPSARALVRSGAQAVALAPLLVLLASLAFSIAFGGPGAIAFP 212

Query: 63  LPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISV-GSPFSIPQMFSARLGIATM 121
           + AL+WCA  Y+P +  LLT + G+  IV VA +++  SV  S   +  + SAR+GIA +
Sbjct: 213 IAALLWCAWTYSPFLVSLLTLIAGSTLIVAVAQNLMHFSVPQSELGVTTLMSARMGIAML 272

Query: 122 AICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYE---ALKSPSLKQTQHL--T 176
            + P++V+    A  SL+ ++A +A  D LT   +RS       AL     K  Q L  T
Sbjct: 273 ILGPLVVACVSQANRSLLARLAHQATIDHLTGALTRSAFTRRANALLDSRQKHAQALPLT 332

Query: 177 VMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPV 236
           +M+LDID+FKSIND +GH  GD+VL  FAR +Q  +    L+ARMGGEEF V +P + P 
Sbjct: 333 LMMLDIDHFKSINDRHGHGVGDQVLRQFARTLQDQLHGGELLARMGGEEFVVLLPGLAPE 392

Query: 237 DGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVG--SGRASYLTLTDDFNKLMVEADTCL 294
                AE++R+ V+            +TVSIG+   +G     TL    ++L+  AD  L
Sbjct: 393 RASFTAERLRRAVQDLHLAKGDGRPQITVSIGLDGCAGHEPAPTL----DELLARADQAL 448

Query: 295 YRSKKDGRNRTSTMRYGEEVV 315
           YR+K  GRNR        +V+
Sbjct: 449 YRAKAHGRNRVEVAETQRQVI 469


>UniRef50_C6CM30 Diguanylate cyclase n=1 Tax=Dickeya zeae Ech1591 RepID=C6CM30_DICZE
          Length = 470

 Score =  192 bits (487), Expect = 2e-47,   Method: Compositional matrix adjust.
 Identities = 122/308 (39%), Positives = 186/308 (60%), Gaps = 6/308 (1%)

Query: 4   DWFSEQFSTGVLIVPCMLTL--AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAF 61
           +WFS+QF T VL +P +LTL   IP  LP  +    +P + L+VS++ + ++G    LAF
Sbjct: 161 NWFSDQFYTAVLFLPLLLTLRSQIPLQLPMLRLSDALPLLLLLVSIVVAPLLGPVAILAF 220

Query: 62  PLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDI-SVGSPFSIPQMFSARLGIAT 120
           PLPAL WCA+ Y   +  L+T   GA E++L A  V    S   P+ + Q+  AR+GIA 
Sbjct: 221 PLPALTWCAIVYPLWLIRLITLCVGATELILTAEHVYAFYSPQDPYFMHQIIIARIGIAA 280

Query: 121 MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLK-QTQH--LTV 177
               P+M++ +   I  L  ++  +A  DFLT   SR G  EAL +     ++QH  + +
Sbjct: 281 TIFSPLMMATNARTIRQLNARLLQQASHDFLTNTLSRYGFTEALTTHGQSVKSQHDAVNI 340

Query: 178 MLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVD 237
           ML+DID+FK+IND++GH+CGD++L   A+ IQ+ V  +GLV+R+GGEEFAV   + NP  
Sbjct: 341 MLIDIDHFKNINDSFGHDCGDEILRQVAKVIQQAVSAQGLVSRIGGEEFAVVCFNYNPSA 400

Query: 238 GLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRS 297
              +A+ +R+ ++   F + Q+ + +TVSIG+     S   L D  ++L   AD  LY +
Sbjct: 401 FYRLADSLRQTIQQTVFLFNQQPVPVTVSIGIAHAPTSGKYLVDTVHELFPLADKNLYTA 460

Query: 298 KKDGRNRT 305
           K++GRNRT
Sbjct: 461 KREGRNRT 468


>UniRef50_D2C311 Diguanylate cyclase n=1 Tax=Dickeya dadantii Ech586
           RepID=D2C311_DICD5
          Length = 471

 Score =  188 bits (477), Expect = 2e-46,   Method: Compositional matrix adjust.
 Identities = 118/311 (37%), Positives = 183/311 (58%), Gaps = 11/311 (3%)

Query: 4   DWFSEQFSTGVLIVPCMLTLA--IPGVLPRFKAEQMMPAIALIV---SVIASVVIGGAGS 58
           +WFS+QF T VL +P +LTL   IP  LP   + QM  A+ L++   S+  + ++G    
Sbjct: 161 NWFSDQFYTAVLFLPLLLTLQSRIPLHLP--ASLQMADALPLLLLLLSICIAPLLGPVAI 218

Query: 59  LAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDI-SVGSPFSIPQMFSARLG 117
           LAFPLPAL WCA+ Y   +  L+T   GA E+++ A  V  + +   P  + Q+  AR+G
Sbjct: 219 LAFPLPALTWCAIVYPLWLIRLITLCVGATELIMTAEHVYALYNPQDPMFLHQVVIARIG 278

Query: 118 IATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLK---QTQH 174
           IA     P+M++ +   I  L  ++  +A  DFLT   SR G  EAL +       Q   
Sbjct: 279 IAATIFSPLMMATNARTIRQLNARLLRQASHDFLTNTLSRYGFTEALSTHDQNIKSQQDA 338

Query: 175 LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVN 234
           + +ML+DID FK+IND++GH+CGD++L   A  IQ+ V  +GLV+R+GGEEFAV   + +
Sbjct: 339 VNIMLIDIDNFKNINDSFGHDCGDEILRQVANVIQRTVSAQGLVSRIGGEEFAVVCFNYS 398

Query: 235 PVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCL 294
           P     +A+++R+ ++   F + Q+ + +TVSIG+   + +   L D  ++L   AD  L
Sbjct: 399 PPAFYRLADELRQTIQHTVFLFNQQHVPVTVSIGIAHAQVAGKHLVDTVHELFPLADKNL 458

Query: 295 YRSKKDGRNRT 305
           Y +K++GRNRT
Sbjct: 459 YTAKREGRNRT 469


>UniRef50_A8GAZ5 Diguanylate cyclase n=2 Tax=Serratia RepID=A8GAZ5_SERP5
          Length = 482

 Score =  176 bits (445), Expect = 1e-42,   Method: Compositional matrix adjust.
 Identities = 117/315 (37%), Positives = 185/315 (58%), Gaps = 17/315 (5%)

Query: 5   WFSEQFSTGVLIVPCMLTLAIPGVLPR----FKAEQMMPAIALIVSVIASVVIGGAGSLA 60
           WFSEQFST +L++P +L       L R    ++    MP +AL+ S++ SV IGG G++A
Sbjct: 158 WFSEQFSTNLLLLPVLLAAPRLKQLLRMQINWQLRASMPLLALLFSLVFSVYIGGPGAIA 217

Query: 61  FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLV-ANSVIDISVGSPFS-IPQMFSARLGI 118
           FP+PAL+WCAVRY      LLT +TG  EI  + AN ++  +  +  + +  + SARLGI
Sbjct: 218 FPIPALLWCAVRYQLFTVTLLTLLTGMTEISSISANLMLYETPNNHIAFLDTLMSARLGI 277

Query: 119 ATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---- 174
           A + + P++++ S+A    L++++   A+ DFLT V +R+ L    K+  L + +H    
Sbjct: 278 AMLVMGPLILASSIAVNRKLLRRLEHSANHDFLTGVLARNALTR--KAGELLEHKHKSKE 335

Query: 175 -LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSV 233
            ++++L+DID+FK IND +GH  GD+VL+ FA  +++ +    L  R+GGEEFA+ +P  
Sbjct: 336 AVSLLLIDIDHFKQINDTHGHLVGDQVLASFAHIVRRELRHDQLFGRLGGEEFAIMLPRA 395

Query: 234 NPVDGLLMAEKIRKGVELQPFTWQQKT-LYLTVSIGVGSGRASYLTLTDDFNKLMVEADT 292
               G+ +AE +R+ V+        K  L +T+S+GV S     +       +LM  AD 
Sbjct: 396 LAAQGVALAEHLRQLVQKADLLPTGKVPLNITISVGVAS---LGMNEVKSLEQLMNMADI 452

Query: 293 CLYRSKKDGRNRTST 307
            LYR+K  GRNR  +
Sbjct: 453 ALYRAKSQGRNRVES 467


>UniRef50_A0P392 GGDEF domain protein n=1 Tax=Labrenzia aggregata IAM 12614
           RepID=A0P392_9RHOB
          Length = 307

 Score =  169 bits (429), Expect = 1e-40,   Method: Compositional matrix adjust.
 Identities = 100/285 (35%), Positives = 152/285 (53%), Gaps = 5/285 (1%)

Query: 26  PGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVT 85
           P  + +F  E+  P I L+VS IA  ++GG G++AFP+PAL+WC + Y    T +LT   
Sbjct: 25  PARIRQFWQEKWAPLILLLVSCIAGTLVGGPGAIAFPVPALLWCGLVYPVFPTTILTLCI 84

Query: 86  GAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALR 145
           G   +V+++N + D S      +  + S RLGI+ +A+ PIM+S      N+L+ ++   
Sbjct: 85  GVWGLVILSNGLGD-SASLQLDVMTLVSIRLGISLVALAPIMLSCVTQNRNALVGRLQYL 143

Query: 146 ADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           A  D LT V +R+   E         T    ++++D+D FK++ND +GH  GD VL  F 
Sbjct: 144 ATHDQLTNVLNRNAFREEAARRLALGTSGFALLMVDLDDFKAVNDTHGHATGDTVLVNFV 203

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF-TWQQKTLYLT 264
             ++  +    L+ RMGGEEFAV +P    VD +  AE IR+ V  +P      K + +T
Sbjct: 204 HRVKNTLPPGSLLGRMGGEEFAVLIPDCRQVDAVAEAENIRQSVGTEPVPAGDGKEVRVT 263

Query: 265 VSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
            S+GV    A      D  + L+ EAD   Y +KK GRNR   + 
Sbjct: 264 ASLGV---VAVEHGDADSLDTLLAEADRLCYLAKKRGRNRVEAIE 305


>UniRef50_D0IXN6 Diguanylate cyclase n=2 Tax=Comamonas testosteroni
           RepID=D0IXN6_COMTE
          Length = 473

 Score =  155 bits (392), Expect = 2e-36,   Method: Compositional matrix adjust.
 Identities = 101/320 (31%), Positives = 168/320 (52%), Gaps = 31/320 (9%)

Query: 5   WFSEQFSTGVLIVPCMLT----------LAIPGVLPRFKAEQMMPAIALIVSVIASVVIG 54
           W S ++   ++ +P +L           L  P  L R     ++P +++I     S  I 
Sbjct: 165 WLSSEWLNYMMFLPIVLAWPTRKQPVGHLGEPSPLRR-----ILPLLSVIALEAISYWIK 219

Query: 55  GAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGS----PFSIPQ 110
           G GSLAF LPALIWCA+ Y       LT +T      L  +S+I IS+G+    P    +
Sbjct: 220 GPGSLAFSLPALIWCALSYR---IFSLTLITA----TLCLSSIIFISLGTLEFTPAHFLE 272

Query: 111 MFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSP 167
             S R+G+  + + P+ V+ S  A N LM++++   + DFLT + +R       + +   
Sbjct: 273 TLSFRMGLCMLVLGPLAVAGSHMARNELMQKLSHAVNHDFLTDMLARGAFMKQGQRILER 332

Query: 168 SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFA 227
             +  Q   +++LD+D+FK IND++GH  GD++L  F++ + +++  + +V RMGGEEFA
Sbjct: 333 CRQDGQPFAILMLDLDHFKQINDSFGHAGGDQLLRSFSQTLSQVLRAQDIVGRMGGEEFA 392

Query: 228 VAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLM 287
           VA+P V+      +A++I + +         KT+  TVSIG+     + L      + L+
Sbjct: 393 VALPKVDASAAQEIAKRINRAIRELRVPMNDKTMSATVSIGL--VHTTSLQAHQSLDMLL 450

Query: 288 VEADTCLYRSKKDGRNRTST 307
           ++AD  LY +K  GRNR S+
Sbjct: 451 LQADQALYEAKAAGRNRVSS 470


>UniRef50_B7GZC2 Uncharacterized protein yneF n=10 Tax=Acinetobacter
           RepID=B7GZC2_ACIB3
          Length = 473

 Score =  151 bits (381), Expect = 3e-35,   Method: Compositional matrix adjust.
 Identities = 92/277 (33%), Positives = 146/277 (52%), Gaps = 11/277 (3%)

Query: 33  KAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVL 92
           KA   +P  A+++S+  S    G GSL +P+ ALIWCA+RY P +  L+T  T A  I  
Sbjct: 198 KAIDFLPLFAVLISIGVSYYDSGPGSLLYPIAALIWCAIRYKPIIVALITSFTSAYIIYH 257

Query: 93  VANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINS-LMKQVALRADFDFL 151
           V+   + +      S     S R+G+  M + P+ VS S++A++S L++++      D L
Sbjct: 258 VSGHYLLLYPQDYLS--NNISIRIGLIMMTVAPLTVS-SISALHSELIQKLQHAIAHDEL 314

Query: 152 TQVYSRSGLYEA---LKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHI 208
           T   +R    ++   L+    K+ +     +LD+D+FK +ND+YGH  GD+ L      I
Sbjct: 315 TSSLTRRQFLQSVRLLQEKVQKENKTSAFFMLDVDHFKKVNDSYGHLIGDRALQTCVTTI 374

Query: 209 QKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP-FTWQQKTLYLTVSI 267
           Q I+    L+ R GGEEFA+ +P         +AE+IR  +  QP + + +  +++ VSI
Sbjct: 375 QNILHPHDLLGRFGGEEFAIFIPDTTREAAFELAERIRIQISQQPIYVYGKLPIFVQVSI 434

Query: 268 GVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           G+     SY         L  EAD  LY++K+ GRNR
Sbjct: 435 GISLYSPSY---HRSIESLFKEADDALYQAKRQGRNR 468


>UniRef50_A8GES9 Diguanylate cyclase n=2 Tax=Serratia RepID=A8GES9_SERP5
          Length = 500

 Score =  150 bits (380), Expect = 4e-35,   Method: Compositional matrix adjust.
 Identities = 106/332 (31%), Positives = 170/332 (51%), Gaps = 41/332 (12%)

Query: 2   LADWFSEQFSTGVLIVPCMLTLAIP------------GVLPRFKAEQMMPAIALIV---- 45
           LA W S +F+  + ++P    LA P             V  R +    +  IA+++    
Sbjct: 173 LALWLSSEFTNYITLMP--FILAFPRDWKGYLRSIFQAVTLRSQWPNTVRKIAVLLLLLL 230

Query: 46  SVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSP 105
           +   S++IGG G++ FP+P L+W A+ ++     L + +   +  VL  +  ID+ + + 
Sbjct: 231 ACFGSILIGGPGAVIFPMPILLWLAMSFS-----LFSTMIAVLVYVLWCHLAIDLGLITT 285

Query: 106 FSIPQMF----SARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY 161
               +M     S RLG+A +A+ PI V+    A N+L++++   A+ D LT V +RS   
Sbjct: 286 NLDMKMLQNTVSMRLGVALLALGPIAVASMNFARNALLQRLEHVANHDALTHVLTRSAFM 345

Query: 162 EALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARM 221
           +       ++ + + +M+LDIDYFKSIND +GH  GD  L  F R I   + D  L  RM
Sbjct: 346 QRGTRLVSQKGERICIMMLDIDYFKSINDRFGHAGGDAALLSFTRAITGDLRDNDLFGRM 405

Query: 222 GGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQ-KTLYLTVSIGV-----GSGRAS 275
           GGEEFA+  P     D L +AE++R  VE++         L +TVSIG+     GSG+  
Sbjct: 406 GGEEFAIVAPIAQQQDALSLAERLRHRVEIESINMPAGAALQITVSIGMVTCIGGSGQ-- 463

Query: 276 YLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
                 + + L+  AD  +Y++K  GRNR +T
Sbjct: 464 ------NLDNLLKIADLAVYKAKNSGRNRVAT 489


>UniRef50_C3JIZ7 Diguanylate cyclase n=2 Tax=Rhodococcus erythropolis
           RepID=C3JIZ7_RHOER
          Length = 471

 Score =  138 bits (347), Expect = 3e-31,   Method: Compositional matrix adjust.
 Identities = 109/329 (33%), Positives = 163/329 (49%), Gaps = 36/329 (10%)

Query: 5   WFSEQFSTGVLIVPCMLTLAI-------PGVLPRFKAEQMMPAIALIVSVIASVVIGGAG 57
           WFS +F   + IVP +LT          P  +       ++P   L V +I   VIGGAG
Sbjct: 158 WFSSEFVNYMTIVPLVLTFPSLRRVDREPKAVATLLRRSVVPTALLAVCIILEWVIGGAG 217

Query: 58  SLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLG 117
           ++AF +PAL+  A+     VT +LT V+ A  +VL A+  + +S  S    P   S ++G
Sbjct: 218 AIAFAMPALVTAALLTNVFVTSVLTAVSTAWTLVLTADGHLGLS--SEGVSPVSASVQIG 275

Query: 118 IATMAICPIMVSFSV----AAINSLMKQV-------ALRADFDFLTQVYSRSGLYEALKS 166
           ++ +A+ PI V+  +     A+ +L + V       ALR D +FL     R G       
Sbjct: 276 LSLLAVAPIAVACVILERRRALEALTQAVTHDDLTGALRRD-EFL----RRGGSVTGATD 330

Query: 167 PSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEF 226
           P     + ++V+++D+D+FK +NDN GH  GD  L  FA  +++ + DK L AR+GGEEF
Sbjct: 331 PRRHSGRPVSVLMMDLDHFKMVNDNLGHRAGDTALVSFADQVRRHLDDKHLFARLGGEEF 390

Query: 227 AVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVG---SGRASYLTLTDDF 283
            V +  V+       AE IR+  + +  +        TVSIGV     G A       D 
Sbjct: 391 VVLMAGVDLEGATETAEMIRRA-QAENSSAVLGDFGPTVSIGVACSPHGDA-------DL 442

Query: 284 NKLMVEADTCLYRSKKDGRNRTSTMRYGE 312
            +L+  AD  LYR+KK  RNRT  +  G 
Sbjct: 443 TQLVDCADEALYRAKKLDRNRTVALTVGS 471


>UniRef50_C6RK39 Diguanylate cyclase n=2 Tax=Acinetobacter radioresistens
           RepID=C6RK39_ACIRA
          Length = 445

 Score =  132 bits (332), Expect = 1e-29,   Method: Compositional matrix adjust.
 Identities = 86/278 (30%), Positives = 145/278 (52%), Gaps = 19/278 (6%)

Query: 36  QMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVAN 95
            ++P   L+ S+  S    G G++ +P+ ALIWCA+ Y      L+T ++       +++
Sbjct: 173 HILPIFVLLFSLSLSYYDSGPGAILYPIAALIWCALNYRHFTVALITSISCFYIAFFMSD 232

Query: 96  SVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINS-LMKQVALRADFDFLTQV 154
             + +     +   +M S R GI TMAI P+ VS S+  I S L++++      D LT  
Sbjct: 233 KYLTLYPEQYYL--EMISLRFGIITMAIAPLTVS-SINRIRSQLIRELQHHVAHDELTAS 289

Query: 155 YSRSGLYEA---LKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKI 211
            +R     +   L     +++Q L V++LDID+FK IND YGH+ GD+ L   A  I++ 
Sbjct: 290 LTRRQFMRSAHLLLRQRTQESQSLAVLMLDIDHFKLINDKYGHQAGDEALRACAAVIRRS 349

Query: 212 VGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGS 271
           +    L  R+GGEEFA+ +  V P +   +AE+IR+ ++        +T + ++ I +G 
Sbjct: 350 LRGYDLFGRLGGEEFAIVLLDVGPAEAFEIAERIRETLKTHIIQLDAETQF-SIRISIG- 407

Query: 272 GRASYLTLTD-----DFNKLMVEADTCLYRSKKDGRNR 304
                LTL +     +   L+ +AD  LY +K+ GR+R
Sbjct: 408 -----LTLFNPAVPHNIEALLHKADLALYEAKRSGRDR 440


>UniRef50_C3JRE9 Diguanylate cyclase n=2 Tax=Rhodococcus erythropolis
           RepID=C3JRE9_RHOER
          Length = 489

 Score =  129 bits (325), Expect = 1e-28,   Method: Compositional matrix adjust.
 Identities = 90/303 (29%), Positives = 150/303 (49%), Gaps = 18/303 (5%)

Query: 24  AIPGVLPRFK--------AEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTP 75
           +IP  L  F+        A   +P +A    V  ++ I G  +L  P+PAL+WCA R + 
Sbjct: 158 SIPSSLAEFRRKLTARTVAALSVPLLATAACVPIALSIEGPIALVLPIPALLWCATRISV 217

Query: 76  QVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAI 135
             T  ++ V     +++  +  +DI   +  +  +     + +  +A+ PI V+ +    
Sbjct: 218 PSTAFVSVVWSVWSLMMAGSGRLDIGDQAASTWNEDVITSIAVTLIALGPIAVACATEER 277

Query: 136 NSLMKQVALRADFDFLTQVYSRS---GLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNY 192
            +  +++ L  +FD LT V SR    G  EA  + + +    + +++LD+D+FKSIND +
Sbjct: 278 RAAERELFLAVEFDHLTGVLSRGAFLGHAEAELADAARTQSPVGLLMLDLDHFKSINDTH 337

Query: 193 GHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQ 252
           GH  GD VL+ FA      + D  L+ R+GGEEFAV +P  +    + +AE +R G +++
Sbjct: 338 GHMTGDSVLANFAERAADRLSDGDLIGRLGGEEFAVLLPDCSFTRAIDVAEAVR-GAQVE 396

Query: 253 PFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGE 312
                +  +  TVS+GV    A     T   + LM  AD  LY +K+ GRN     R G 
Sbjct: 397 YSA--ESDVTSTVSVGV----AWVDHATPALSTLMSVADEALYDAKRAGRNLVKVHRVGN 450

Query: 313 EVV 315
           + V
Sbjct: 451 DTV 453


>UniRef50_C6DKF8 Diguanylate cyclase n=5 Tax=Pectobacterium RepID=C6DKF8_PECCP
          Length = 489

 Score =  129 bits (324), Expect = 1e-28,   Method: Compositional matrix adjust.
 Identities = 99/331 (29%), Positives = 154/331 (46%), Gaps = 30/331 (9%)

Query: 4   DWFSEQFSTGVLIVPCMLT--------LAIPGVLPRFKAEQMMPAIALIVSVIASVVIGG 55
           DWFSEQ  TG+++    L           IP + P+   E + P +  I+ ++ S+    
Sbjct: 169 DWFSEQLGTGIILAFFFLRGKDILRALRNIP-LCPKHIRENIFPFLVFIIFLLVSLFFQD 227

Query: 56  AGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSV-IDISVGSPFSIPQMFS- 113
           A  +   +  L  CA  Y+  +  LL  +TG +   L  N V I I+  S   I    + 
Sbjct: 228 ASLITLSVIPLTLCAFNYSFPIMSLLCAITGVILNYLYINQVGILINSNSEAYINSFLTT 287

Query: 114 ARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPS----L 169
           ARL IA + +  + VS  V+    L+K +   +  D LT  ++R      L         
Sbjct: 288 ARLNIAMLIMAMLSVSHFVSMNRRLIKIIESNSLKDALTNTFNRRAFLSMLNGRQGLLMN 347

Query: 170 KQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVA 229
           K+ + LT++ LDIDYFK +ND YGH  GD++++ FAR +   +    ++ R GGEEF +A
Sbjct: 348 KRKRQLTLLFLDIDYFKQVNDTYGHASGDELIASFARMLSANIRPSDILCRWGGEEFVIA 407

Query: 230 VPSVNPVDGLLMAEKIRKGVELQPFTWQQ-KTLYLTVSIGVGS-----GRASYLTLTDDF 283
              +       MAE +R   E  P      + +  T+SIGV +     G  +Y       
Sbjct: 408 AYDLTAEQSAAMAETLRHLTESTPLVLSDGREIRFTISIGVVTFPQYEGGNTY------- 460

Query: 284 NKLMVEADTCLYRSKKDGRNRTSTMRYGEEV 314
             L+  AD  LY++K  GRNR   +R  E++
Sbjct: 461 -DLIGLADEQLYKAKAQGRNRVC-LRLVEDI 489


>UniRef50_Q7CZM8 GGDEF family protein n=1 Tax=Agrobacterium tumefaciens str. C58
           RepID=Q7CZM8_AGRT5
          Length = 415

 Score =  128 bits (321), Expect = 3e-28,   Method: Compositional matrix adjust.
 Identities = 82/223 (36%), Positives = 122/223 (54%), Gaps = 20/223 (8%)

Query: 92  LVANSVIDISVGSPFSIPQMFSARLGIATMA--ICPIMVSFSVAAINSLMKQVALR---- 145
           +VA+ VI  +   P +IP M SA L I+ M      IM+S  +     +M+   +R    
Sbjct: 163 IVASIVIPANAAVPNAIP-MTSA-LSISGMLGFTAIIMISAKI-----IMEDTEIRLHRL 215

Query: 146 ADFDFLTQVYSRSGL---YEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLS 202
           A  D LT V +R GL   +E +K  S    +++ ++L DID+FK IND YGH+ GD VL 
Sbjct: 216 AMTDHLTGVLNRRGLLEEFEHIKKRSHGSDRYVALVLFDIDHFKKINDRYGHQSGDAVLV 275

Query: 203 VFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY 262
            F    Q+++G++GL  RMGGEEFA+     +P   + +AE IR  + L   T + + + 
Sbjct: 276 HFCNIAQRVIGERGLFVRMGGEEFALVAEVESPSSTVTLAEAIRSNLRLSKITARNEAIK 335

Query: 263 LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
           +T S+G+       +    D + +M EAD  LY +KK GRNRT
Sbjct: 336 VTTSVGISEA----MIKDADLSVMMTEADRALYAAKKAGRNRT 374


>UniRef50_A9C2H0 Diguanylate cyclase n=2 Tax=cellular organisms RepID=A9C2H0_DELAS
          Length = 496

 Score =  127 bits (320), Expect = 4e-28,   Method: Compositional matrix adjust.
 Identities = 79/264 (29%), Positives = 147/264 (55%), Gaps = 9/264 (3%)

Query: 45  VSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGS 104
           +S   ++ +GG G+L+  +PA++ CA+RY   V  LL  V+ A+++   ++ V+  S G+
Sbjct: 211 ISESIAIYLGGPGALSLTMPAMLLCAMRYRLFVVALLNLVSCAIKLATFSH-VLFSSPGT 269

Query: 105 PFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEAL 164
              +   FS RLG+A ++I P+ V+ ++ A   ++ ++    + D LT + +R+   E  
Sbjct: 270 --ELETTFSFRLGLAMLSIGPLAVACTLMAFKDMLSKLRHAVNHDALTGLLARTSFLERA 327

Query: 165 KSPS---LKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARM 221
           +       ++ Q   +++LD+D+FK IND +GH  GD+VL   +  + + +    L+ R+
Sbjct: 328 QRTLERLQRERQSGAMLMLDLDHFKHINDRHGHAAGDRVLQEVSARLSQALRPHELIGRL 387

Query: 222 GGEEFAVAVPSVNPVDGLLMAEKIRKGV-ELQPFTWQQKTLYLTVSIGVGSGRASYLTLT 280
           GGEEFAV +P  + V    +A+++ +   E++        +  T+SIG+G    +Y  L 
Sbjct: 388 GGEEFAVLLPGADCVTARAVAQRLCEATREIRIDMNDGAAICPTLSIGIGCTNMAYPPL- 446

Query: 281 DDFNKLMVEADTCLYRSKKDGRNR 304
              + L+  ADT LY++K  GR+R
Sbjct: 447 -GLSALLRMADTALYQAKASGRDR 469


>UniRef50_D0S942 Response regulator n=2 Tax=Acinetobacter RepID=D0S942_ACIJO
          Length = 476

 Score =  125 bits (315), Expect = 1e-27,   Method: Compositional matrix adjust.
 Identities = 90/316 (28%), Positives = 156/316 (49%), Gaps = 27/316 (8%)

Query: 5   WFSEQFSTGVLIVPCMLTLAIPGVLP-----RFKAE----QMMPAIALIVSVIASVVIGG 55
           W++ +    + ++P MLT      L      R + E     ++P +++++SV  + +  G
Sbjct: 167 WWTGEVLNCISLLPLMLTFPAAKKLKYLWNNRRQCETQFVDVLPLLSVLISVACTHLFFG 226

Query: 56  AGSLAFPLPALIWCAVRYT----PQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQM 111
            G+L FPL  LIW A+ Y       +  L+ FVT         +   D  + +  S+   
Sbjct: 227 PGALLFPLAGLIWAALSYNLFYVSIINSLVCFVTYHSLTTYYISRTADNFLATSISV--- 283

Query: 112 FSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPS 168
              R+G+  + I P+++       + L K+V   A+ D LT V +R   +   E L   +
Sbjct: 284 ---RIGLCMLMIAPLLLCIVSRNRHDLYKEVLYLANHDPLTHVGNRRFFFTQTENLLKEN 340

Query: 169 LKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAV 228
           L ++  +++++LDID+FK +ND YGH  GD +L  FA  ++  + ++ L ARMGGEEF V
Sbjct: 341 LVKS--MSIIVLDIDHFKKMNDQYGHYIGDVLLQSFATTVKSNLREQDLFARMGGEEFVV 398

Query: 229 AVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMV 288
            + +   ++  ++AE+I + V           L +TVS+GV       L   +    L+ 
Sbjct: 399 VLNNTTEIESQIIAERICRAVATSKTQVAHAVLSMTVSLGVVH---QVLPTQNSLQSLLN 455

Query: 289 EADTCLYRSKKDGRNR 304
            AD  LY++K  GRN+
Sbjct: 456 RADRALYQAKTLGRNQ 471


>UniRef50_B1YEE7 Diguanylate cyclase n=1 Tax=Exiguobacterium sibiricum 255-15
           RepID=B1YEE7_EXIS2
          Length = 373

 Score =  123 bits (309), Expect = 7e-27,   Method: Compositional matrix adjust.
 Identities = 69/180 (38%), Positives = 104/180 (57%), Gaps = 11/180 (6%)

Query: 139 MKQVALRADFDFLTQVYSRSGL---YEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHE 195
           ++Q A R   DFLT +++        E LK  ++  ++ + ++ +DID+FK IND YGHE
Sbjct: 194 LQQTARR---DFLTGLHNFRAFTDHLEDLKQQTILHSREVALITVDIDHFKQINDTYGHE 250

Query: 196 CGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFT 255
            GD+VL  FA+ +Q  V D G V+R GGEEF++ V  +  V  L +AE++R+ +   PF 
Sbjct: 251 AGDEVLRQFAKRLQDGVTDSGYVSRNGGEEFSILVERLTVVKVLALAEQLREQIAAAPFV 310

Query: 256 WQQKT-LYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEV 314
                 L+LT S GV    AS+   T     ++ +AD  LY+SK++GRNR +     EEV
Sbjct: 311 LSSGMLLHLTASFGV----ASFPETTGQIQHIVTDADAALYQSKQNGRNRVTLFSLQEEV 366


>UniRef50_Q2RNW0 Putative diguanylate cyclase (GGDEF domain) n=1 Tax=Rhodospirillum
           rubrum ATCC 11170 RepID=Q2RNW0_RHORT
          Length = 360

 Score =  123 bits (308), Expect = 9e-27,   Method: Compositional matrix adjust.
 Identities = 91/272 (33%), Positives = 133/272 (48%), Gaps = 24/272 (8%)

Query: 46  SVIASVVIGGAGSLA-------FPLPALIWCAVRYTPQVTCLL-TFVTGAVEIVLVANSV 97
           +VI +VV+GG    A       FP+        R    V+ +  T  T  V I+ V +  
Sbjct: 99  AVILTVVLGGKAQDAVFSWAVLFPVLPFFVLGQRLGLLVSIVFATTATVGVTILAVLDGA 158

Query: 98  IDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSR 157
              S  +PF++            +A C ++  F         +Q+   A  D LT + +R
Sbjct: 159 QGFSWIAPFNLA---------GALAGCTVLAYFYEGTRAKAARQLETLAKSDPLTGLANR 209

Query: 158 SGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGD 214
            GL +A     L +++    L++++LD+D+FKSIND YGHE GD VL   A  I+ ++  
Sbjct: 210 RGLLDAFGGAVLTRSRAPHRLSLLVLDLDHFKSINDRYGHEAGDGVLCHVAHVIKGMIRA 269

Query: 215 KGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRA 274
             L+AR+GGEEFA+ +P  +      +AEKIRK +E         +L +TVSIGV     
Sbjct: 270 NDLIARIGGEEFALLLPDTDLAGAREVAEKIRKAIESTALIGPGGSLSVTVSIGVAELDP 329

Query: 275 SYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
            Y     DF  L   AD  LY++KK GRNR S
Sbjct: 330 QY----PDFAALFSSADHRLYQAKKAGRNRVS 357


>UniRef50_Q310L5 Diguanylate cyclase (GGDEF domain) n=2 Tax=Desulfovibrio
           RepID=Q310L5_DESDG
          Length = 525

 Score =  119 bits (299), Expect = 1e-25,   Method: Compositional matrix adjust.
 Identities = 67/181 (37%), Positives = 105/181 (58%), Gaps = 7/181 (3%)

Query: 127 MVSFSVAAINSLM-KQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDI 182
           M   ++A  N+L+ +++ L+AD D LTQ+++R      L+    +  ++   LT+M+LDI
Sbjct: 331 MRHLALAVKNALLFREMRLQADHDGLTQLHNRRHFDTRLREELDRHGRYSMPLTLMMLDI 390

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           DYFK IND +GH+ GD VL   A  +++ +      AR GGEEF   +P  +     ++A
Sbjct: 391 DYFKQINDRFGHQAGDAVLRELASVLRETIRTTDYCARYGGEEFVAILPHTDEQQARVLA 450

Query: 243 EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           E++RK +E + F    KT+  TVSIG+   +   LT  D+   L+ EAD  LY +K +GR
Sbjct: 451 ERLRKNIESRVFRHHGKTIQATVSIGLTGFKPGALTPRDE---LVREADAALYLAKANGR 507

Query: 303 N 303
           N
Sbjct: 508 N 508


>UniRef50_B7RWX6 GGDEF domain protein n=1 Tax=marine gamma proteobacterium HTCC2148
           RepID=B7RWX6_9GAMM
          Length = 390

 Score =  119 bits (297), Expect = 2e-25,   Method: Compositional matrix adjust.
 Identities = 61/217 (28%), Positives = 122/217 (56%), Gaps = 10/217 (4%)

Query: 96  SVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVY 155
           ++ ++++G   ++ Q+ +   G  + A   + V F  + +    + ++  A  D LT++ 
Sbjct: 168 ALYEVAIGGDSNLGQIIA--FGAHSWAYVLVAVGFLASVLIEYQQHLSHLATEDPLTRLL 225

Query: 156 SRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIV 212
           +R GL +AL+       +H    + +++DIDYFK +ND++GHE GD V+ + A  I+++ 
Sbjct: 226 NRRGLQDALRISIAHARRHGLPTSAIMIDIDYFKRVNDSFGHETGDHVIQLVASMIERLC 285

Query: 213 GDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSG 272
            +  +VAR GGEEF + + + +     ++AE++R+ V  +P    Q  + +T+S+GV S 
Sbjct: 286 RESDVVARTGGEEFLIILANTDSASARILAERVRQAVGERPLVVDQHRIPVTISLGVASA 345

Query: 273 RASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
              +     + ++L  EAD  +Y +K+ GRNR +++ 
Sbjct: 346 SGEF-----NLDELSQEADQAMYLAKRGGRNRVASVE 377


>UniRef50_Q3AFS2 GGDEF domain protein n=1 Tax=Carboxydothermus hydrogenoformans
           Z-2901 RepID=Q3AFS2_CARHZ
          Length = 543

 Score =  117 bits (294), Expect = 4e-25,   Method: Compositional matrix adjust.
 Identities = 62/162 (38%), Positives = 96/162 (59%), Gaps = 7/162 (4%)

Query: 146 ADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLS 202
           A  D LT +Y+R    E L    L+  +H    T++LLDIDYFK IND YGH+CGD VL+
Sbjct: 379 AQKDELTGLYNRRYFLERLNEEHLRSRRHKLNYTIVLLDIDYFKKINDTYGHDCGDLVLN 438

Query: 203 VFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY 262
            F R ++  +    L AR GGEEF V +P     +  L+AE++R+ V+ +   +Q + + 
Sbjct: 439 DFGRFLKDTLRRTDLSARYGGEEFVVLLPQTGKKEAYLLAERLREKVKERVLIFQGQKVK 498

Query: 263 LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
            TVS+G+    A+Y    +++ +L+  AD  LY++K  GR++
Sbjct: 499 YTVSMGL----AAYPEDAEEYRELLSLADKALYQAKNRGRDK 536


>UniRef50_C6BU46 Diguanylate cyclase n=1 Tax=Desulfovibrio salexigens DSM 2638
           RepID=C6BU46_DESAD
          Length = 490

 Score =  117 bits (292), Expect = 7e-25,   Method: Compositional matrix adjust.
 Identities = 70/187 (37%), Positives = 104/187 (55%), Gaps = 11/187 (5%)

Query: 130 FSVAAINSLM-KQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ----HLTVMLLDIDY 184
            S+A  N++M  ++  RA+ D LT+VY+R    E L     K+ Q     L+++++D+DY
Sbjct: 302 LSLALSNAIMFNKIKTRANRDGLTRVYNRRSFDERL-VEEFKRHQRLNTELSLLMVDLDY 360

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEK 244
           FK++ND YGH  GD VL   AR  +K       +AR GGEEF + +P        ++AE+
Sbjct: 361 FKAVNDTYGHMAGDMVLEKVARMFEKTFRSTDFIARYGGEEFVILLPHTREDQAEMLAER 420

Query: 245 IRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           IR  +E    T+Q K+  +T SIGV S R   L   +   +++ +AD  LY +K  GRNR
Sbjct: 421 IRAKIESCAMTYQDKSFNITASIGVSSVRPGSL---EKDTEIVRKADEALYDAKMQGRNR 477

Query: 305 --TSTMR 309
              S MR
Sbjct: 478 VVVSPMR 484


>UniRef50_A5V9Q8 Diguanylate cyclase n=1 Tax=Sphingomonas wittichii RW1
           RepID=A5V9Q8_SPHWW
          Length = 390

 Score =  116 bits (291), Expect = 9e-25,   Method: Compositional matrix adjust.
 Identities = 63/168 (37%), Positives = 97/168 (57%), Gaps = 8/168 (4%)

Query: 149 DFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LT VY+R G  +A +     + +Q Q L+V++ DID FK+IND YGH  GD+ L  FA
Sbjct: 227 DMLTGVYNRRGFEDAAERAIRNAHRQRQPLSVVVADIDGFKAINDRYGHGVGDRALRHFA 286

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
             I+++V    L+ R+GGEEFA+ + +  P D + + E+IR+ +   P +   + + +T 
Sbjct: 287 SRIERLVRRGDLIGRIGGEEFALLLVNTRPQDAVEVVERIRRDIAAMPVSGPDRVV-MTA 345

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEE 313
           S G+   R   ++L      L+  AD  LYRSK DGR+R ++    EE
Sbjct: 346 SFGLTGLRPGDISLA----SLLARADRALYRSKLDGRDRVTSAEELEE 389


>UniRef50_Q73IE7 Response regulator/GGDEF domain protein n=20 Tax=Rickettsiales
           RepID=Q73IE7_WOLPM
          Length = 460

 Score =  116 bits (290), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 72/194 (37%), Positives = 108/194 (55%), Gaps = 21/194 (10%)

Query: 132 VAAINSLMK----QVALRADF---------DFLTQVYSRSGLYEALKS---PSLKQTQHL 175
           +A +NS +K    Q ALR +          D LT  Y+R      L++    S+++ + L
Sbjct: 267 IARVNSQVKRKRYQDALRMNLFNNAEMSIKDPLTNCYNRRYFDAHLRNIVKDSVEKDRRL 326

Query: 176 TVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNP 235
           ++M+LDIDYFK +ND++GH  GD++L    + I + +    L+AR GGEEF V +P  N 
Sbjct: 327 SLMILDIDYFKIVNDSFGHSAGDELLKQIQKRISENIRVTDLLARFGGEEFVVVMPDTNV 386

Query: 236 VDGLLMAEKIRKGVELQPFTWQQK--TLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTC 293
            D   +AE+IRK +  +PF    K  T  +TVSIG+   + S L   D+  + +V AD  
Sbjct: 387 SDAYTIAERIRKIIAKKPFILADKNTTHDVTVSIGIAEMQESDL---DNIKEFIVRADKY 443

Query: 294 LYRSKKDGRNRTST 307
           LY++K  GRNR  T
Sbjct: 444 LYKAKNSGRNRVVT 457


>UniRef50_C4LFT4 Diguanylate cyclase n=1 Tax=Tolumonas auensis DSM 9187
           RepID=C4LFT4_TOLAT
          Length = 392

 Score =  116 bits (290), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 68/187 (36%), Positives = 103/187 (55%), Gaps = 16/187 (8%)

Query: 128 VSFSVAAINS--LMKQVALRADFDFLTQVYSRSGLYEA----LKSPSLKQTQHLTVMLLD 181
           +SFS+  I S  L +++A  A +D LT +Y+R GL E       S         +V ++D
Sbjct: 204 LSFSIMLITSQWLQQKLAAFASYDALTGIYNRYGLNEQSAALFNSDGKLSATDYSVAMID 263

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           IDYFK  ND+YGH  GD VL   A  +++ +    ++AR GGEEF V +P  N  D L  
Sbjct: 264 IDYFKKTNDDYGHPVGDAVLKEVAERLRQNIRHHDILARYGGEEFIVVLPGTNITDALHW 323

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGV----GSGRASYLTLTDDFNKLMVEADTCLYRS 297
           AE++R  V  +P    Q  + +T+SIGV    G  + S       F++ + +AD  LY++
Sbjct: 324 AERVRAQVAAKPIQVDQHAIQITLSIGVVALPGKDKHS------AFDEAIRQADIALYQA 377

Query: 298 KKDGRNR 304
           K++GRN+
Sbjct: 378 KENGRNQ 384


>UniRef50_B5YJX2 Diguanylate cyclase n=1 Tax=Thermodesulfovibrio yellowstonii DSM
           11347 RepID=B5YJX2_THEYD
          Length = 252

 Score =  115 bits (288), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 59/160 (36%), Positives = 95/160 (59%), Gaps = 8/160 (5%)

Query: 148 FDFLTQVYSRS-GLYEALK--SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVF 204
           FD LT VY+R+ G+   ++  + S +  QHL+V +LDID FKSINDNYGH  GD+VL+  
Sbjct: 86  FDELTSVYNRTTGINRLMEEMARSKRHKQHLSVAMLDIDNFKSINDNYGHLAGDRVLNHI 145

Query: 205 ARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLT 264
           A  I+ ++    +V+R GGEEF + +P  + +   +  E++R+ +  +P       L +T
Sbjct: 146 ALQIKNLLRASDVVSRYGGEEFLIILPETDEIKAFMALERVRENIARRPVKIGNGKLNIT 205

Query: 265 VSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           VSIG+     + + + D     +  AD  L ++K+DG+NR
Sbjct: 206 VSIGI-----TEVDINDSSTDAIQRADLALLKAKRDGKNR 240


>UniRef50_Q3IKV1 Putative uncharacterized protein n=2 Tax=Alteromonadales
           RepID=Q3IKV1_PSEHT
          Length = 394

 Score =  115 bits (288), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 68/194 (35%), Positives = 113/194 (58%), Gaps = 11/194 (5%)

Query: 114 ARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLK 170
           A L I T+  C +++ F + A NS  K + L A+ D LTQ+ +R G +   + +K+ +  
Sbjct: 189 AHLFITTL--CALILPFIIFA-NSESKLINL-ANNDSLTQLLNRRGFFSTCKNIKANTAD 244

Query: 171 QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAV 230
           +   L +++LDID+FK +ND YGH+ GD+ L   A+HI ++  + G+ AR+GGEEFAV +
Sbjct: 245 KNHTLALIMLDIDFFKRVNDKYGHDVGDQALKWIAQHISQLFMNIGITARIGGEEFAVLL 304

Query: 231 PSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEA 290
                     +AE++   +  QPF    +++ L+VS GV S   + L L +    L++ A
Sbjct: 305 NGYTLEQANTLAEQLSFNIRQQPFYCNDQSIPLSVSAGVSSTTINQLNLKE----LLLHA 360

Query: 291 DTCLYRSKKDGRNR 304
           D  LY +K+ GR++
Sbjct: 361 DKHLYLAKETGRDK 374


>UniRef50_Q486E7 Sensory box/GGDEF domain protein n=2 Tax=Proteobacteria
           RepID=Q486E7_COLP3
          Length = 428

 Score =  115 bits (287), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 63/180 (35%), Positives = 103/180 (57%), Gaps = 7/180 (3%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKS 187
            ++  N L++++ L +  D LT++Y+R    E L S    S +  +  ++++LDID+FKS
Sbjct: 251 DISEKNQLLEELILSSRRDPLTELYNRRYFTELLHSEITRSRRFKRGFSLLMLDIDHFKS 310

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           IND YGH CGD  L  F++ +   + +   + R GGEEF V +P +  V  +++AEKIRK
Sbjct: 311 INDRYGHACGDAALIAFSKAVTNSIREVDTICRWGGEEFLVLLPEIPKVTAMVVAEKIRK 370

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
            +E     ++   + +TVSIG+       + ++   NK+    D  LYR+K  GRN+ ST
Sbjct: 371 NIENLETIYEGDLIKVTVSIGLEYFSGDAIEMSSMINKV----DQILYRAKDTGRNKIST 426


>UniRef50_Q15NS8 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) n=1
           Tax=Pseudoalteromonas atlantica T6c RepID=Q15NS8_PSEA6
          Length = 965

 Score =  115 bits (287), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 63/188 (33%), Positives = 104/188 (55%), Gaps = 9/188 (4%)

Query: 123 ICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSL---KQTQHLTVML 179
           IC  +V   ++A  S  + +   A  D LT  Y R    ++L    L   +Q + LT++ 
Sbjct: 510 ICGSVVD--ISARKSDHQSIEYMASHDTLTGFYQRQAFEKSLHEAILFAKQQQEELTLLH 567

Query: 180 LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGL 239
           ++ID FK+IND +GH+ GD VL   ++ ++KIV D G++ R+GG+EF + +   N  +  
Sbjct: 568 VNIDQFKAINDTHGHKAGDAVLRQLSQLMKKIVSDDGMIGRLGGDEFGILLVGNNAQNSF 627

Query: 240 LMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKK 299
           ++A K+   V++  FTW+++ L L VSI    G+  +        +L+  AD+  Y +KK
Sbjct: 628 MLANKLLNAVQVHEFTWEERPLTLGVSI----GQVPWNDTISSSEQLLSMADSACYMAKK 683

Query: 300 DGRNRTST 307
            GRNR  T
Sbjct: 684 HGRNRLHT 691


>UniRef50_C8W1N2 Diguanylate cyclase n=1 Tax=Desulfotomaculum acetoxidans DSM 771
           RepID=C8W1N2_DESAS
          Length = 368

 Score =  114 bits (285), Expect = 4e-24,   Method: Compositional matrix adjust.
 Identities = 68/182 (37%), Positives = 104/182 (57%), Gaps = 8/182 (4%)

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLYEALK--SPSLKQTQHL-TVMLLDIDYFKSINDN 191
           +NSL ++    A  DFLT + +  G  E +     + KQT H+ +++ +DID+FK IND 
Sbjct: 185 LNSLYRKFRSEAKQDFLTGLNNVRGFDEEINFLMNNSKQTSHVVSLLFIDIDFFKKINDT 244

Query: 192 YGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVEL 251
           YGH  GD +L   A  + K+   K  V+R GGEEF++ +        + +AE+IR  +E 
Sbjct: 245 YGHIAGDAILIELADLLPKLCSYKDTVSRNGGEEFSIILRDCPLSKAIEVAERIRSIIEK 304

Query: 252 QPFT-WQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRY 310
            PF       + +TVSIGV    A+Y    D+ NKL+ +ADT LY++K+ GRN+ S ++ 
Sbjct: 305 YPFKLLNNNIINITVSIGV----ANYPDTIDEINKLIEKADTSLYKAKRTGRNKVSIIQD 360

Query: 311 GE 312
            E
Sbjct: 361 DE 362


>UniRef50_C8X007 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8X007_DESRD
          Length = 531

 Score =  114 bits (285), Expect = 5e-24,   Method: Compositional matrix adjust.
 Identities = 60/159 (37%), Positives = 89/159 (55%), Gaps = 7/159 (4%)

Query: 149 DFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LT +Y+R   +E  +    +  ++   +T++LLDIDYFK IND YGH+ GD  L    
Sbjct: 360 DELTGLYNRRRFFELARGEFNRAKRYSSPMTILLLDIDYFKRINDEYGHDAGDTALRCIV 419

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
             I   +    ++AR+GGEEF   +P  +  D   +AE+IR  +E       + TL++TV
Sbjct: 420 SMIASQLRSLDVLARLGGEEFVALLPETHQFDAERIAERIRSEIESTAINLFETTLFVTV 479

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           SIGV    A Y     D  +L+  AD  +YR+K+DGRN+
Sbjct: 480 SIGV----AGYSKEMQDVGELINRADEAMYRAKRDGRNQ 514


>UniRef50_Q65IC8 GGDEF-domain containing protein n=1 Tax=Bacillus licheniformis ATCC
           14580 RepID=Q65IC8_BACLD
          Length = 362

 Score =  114 bits (285), Expect = 5e-24,   Method: Compositional matrix adjust.
 Identities = 63/174 (36%), Positives = 101/174 (58%), Gaps = 8/174 (4%)

Query: 138 LMKQVALRADFDFLT---QVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGH 194
           L+K+    +  D+LT    V     ++ A  S + ++ + L+++L+DIDYFK+IND YGH
Sbjct: 191 LLKKYEEESSIDYLTGLNNVRQFDAIWNAHISNAKEKNEKLSLLLIDIDYFKTINDTYGH 250

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP- 253
             GD +L      ++K    + +V+R GGEEF+V +P+ +      +AE++RK VE    
Sbjct: 251 SNGDAILKELGTILKKSARSEDIVSRNGGEEFSVILPNCSHSQAAEIAERVRKEVETHTF 310

Query: 254 FTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
           F    K +++TVSIGV    A++  +     +L+ +AD CLYR+K  GRNR  T
Sbjct: 311 FISHSKKIHITVSIGV----AAFPEVIHSTGELIEKADQCLYRAKHLGRNRVCT 360


>UniRef50_D1U9C4 Diguanylate cyclase n=1 Tax=Desulfovibrio aespoeensis Aspo-2
           RepID=D1U9C4_9DELT
          Length = 498

 Score =  114 bits (284), Expect = 5e-24,   Method: Compositional matrix adjust.
 Identities = 63/169 (37%), Positives = 97/169 (57%), Gaps = 6/169 (3%)

Query: 138 LMKQVALRADFDFLTQVYSRSGLYEAL--KSPSLKQTQH-LTVMLLDIDYFKSINDNYGH 194
           + K+V LRAD D LT++Y+R    E L  +    ++  H L+++++D+D+FK +ND YGH
Sbjct: 317 IFKEVKLRADRDGLTRIYNRHSFDERLIYEIKRRRRYNHDLSLLMVDLDHFKQVNDTYGH 376

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
           + GD VL      + +      L AR GGEEF V +P  +      +AE+IR+ ++   F
Sbjct: 377 KAGDMVLRKVGEILTETFRTTDLAARYGGEEFVVLLPHTSEEAAWKLAERIRESIQGCVF 436

Query: 255 TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
            +      +T SIGV S  A  LT  DD   L+++AD  LY++K +GRN
Sbjct: 437 RFDGHEFSVTASIGVASVEAGALTRDDD---LLIKADKALYKAKNNGRN 482


>UniRef50_A8H0B9 Diguanylate cyclase and serine/threonine protein kinase with TPR
           repeats n=5 Tax=Shewanella RepID=A8H0B9_SHEPA
          Length = 684

 Score =  114 bits (284), Expect = 6e-24,   Method: Compositional matrix adjust.
 Identities = 60/162 (37%), Positives = 97/162 (59%), Gaps = 7/162 (4%)

Query: 146 ADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLS 202
           A  DFLT + +R+ ++   + +   ++K+   L V++ DID FKSIND YGH+ GD  + 
Sbjct: 519 AQTDFLTGIANRAHVFNRGQRMIDRAIKKKHPLAVIIFDIDNFKSINDQYGHQVGDLAIK 578

Query: 203 VFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY 262
             A+  ++ + D  L+ R+GGEEF + +P V   D +L++E++R+G+  Q F +    + 
Sbjct: 579 AVAKRGERWLRDCDLIGRIGGEEFLIVLPDVTEADAILISERLREGIASQAFKFDDVVIE 638

Query: 263 LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           LTVSIGV + +     LTD    L+  AD  LY++K  G+NR
Sbjct: 639 LTVSIGVAALKPPQTRLTD----LVNLADKGLYKAKFSGKNR 676


>UniRef50_Q47C76 PAS:GGDEF n=1 Tax=Dechloromonas aromatica RCB RepID=Q47C76_DECAR
          Length = 548

 Score =  114 bits (284), Expect = 7e-24,   Method: Compositional matrix adjust.
 Identities = 68/192 (35%), Positives = 102/192 (53%), Gaps = 16/192 (8%)

Query: 122 AICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVM 178
            IC I  S  +  I    K++   + FD LT +++R   +   K   + S +    L+VM
Sbjct: 358 GICGI--STDITPIKHYQKELERLSQFDELTNLFNRRHFFSLAKHELNRSSRYRSKLSVM 415

Query: 179 LLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDG 238
           +LDID+FK IND +GH+ GD VL+   + I   + D  +  RMGGEEFA+ +P  +    
Sbjct: 416 MLDIDHFKRINDGHGHKTGDLVLANIGKQIGDSLRDSDIAGRMGGEEFAILLPETDLEQA 475

Query: 239 LLMAEKIRKGVELQPFTW----QQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCL 294
            +MAE++RK V     TW      +TL  T+SIG+ +     +    D   L+ +ADT L
Sbjct: 476 SIMAERLRKQV---AETWLDIGDGRTLNCTLSIGLATKSDQQI----DLENLLHQADTAL 528

Query: 295 YRSKKDGRNRTS 306
           Y +K  GRN+ S
Sbjct: 529 YAAKNSGRNKVS 540


>UniRef50_Q0A9X2 Diguanylate cyclase n=3 Tax=Proteobacteria RepID=Q0A9X2_ALHEH
          Length = 295

 Score =  113 bits (283), Expect = 7e-24,   Method: Compositional matrix adjust.
 Identities = 64/180 (35%), Positives = 102/180 (56%), Gaps = 8/180 (4%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH----LTVMLLDIDYFK 186
            V A  +L +++   A  D LT VYSR  + E  +    ++ +     LT++++D+D+FK
Sbjct: 109 EVQARETLAEELHRLAMMDDLTGVYSRRQVLEVGERELARRRRQGLTPLTLLMMDLDHFK 168

Query: 187 SINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIR 246
            IND YGH  GD VL  F+  +++ + +   V R+GGEEF   +P V+   GL +AE+IR
Sbjct: 169 RINDKYGHAAGDTVLVAFSEVLRRNLRESDAVGRLGGEEFLAVLPDVDLQGGLALAERIR 228

Query: 247 KGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
             +      WQ++ + LTVSIGV    A  L + +  +  ++ AD  LY++K  GRNR +
Sbjct: 229 SEIAELRIPWQEEAIRLTVSIGV----AGILAVHESLDDTIMRADDALYQAKVAGRNRVT 284


>UniRef50_A4JKJ0 Diguanylate cyclase n=2 Tax=Burkholderia RepID=A4JKJ0_BURVG
          Length = 413

 Score =  113 bits (283), Expect = 8e-24,   Method: Compositional matrix adjust.
 Identities = 74/207 (35%), Positives = 105/207 (50%), Gaps = 15/207 (7%)

Query: 107 SIPQMFSAR----LGIATMAICPIMVSFSVAAINS-LMKQVALRADFDFLTQVYSRSGLY 161
           S P MF++     L +A  AI P +   S+  ++  L+      A+ DFLT   SR G +
Sbjct: 203 SSPLMFASTGNVILLVAAAAIMPTLSMSSMMMVHDVLLADAREAANRDFLTGALSRKG-F 261

Query: 162 EALKSPSL----KQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGL 217
           EA+    L    KQ     +++LD+D+FK+IND  GH  GD VL  F R  Q  +    +
Sbjct: 262 EAVAHVQLAEAGKQGSPTALLILDLDHFKAINDTLGHAGGDAVLREFVRVTQMQLRRGDV 321

Query: 218 VARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYL 277
           + RMGGEEFAV +P+    D   +AE++R  V  QP T        ++S GV   RA   
Sbjct: 322 LGRMGGEEFAVLLPATALDDARAIAERLRHAVAAQPMTTAAGPCRYSISCGVAGWRAG-- 379

Query: 278 TLTDDFNKLMVEADTCLYRSKKDGRNR 304
              +  + L   AD  LY +K+ GRNR
Sbjct: 380 ---ETLDHLSARADAALYEAKRSGRNR 403


>UniRef50_Q4KDW8 GGDEF domain protein n=6 Tax=Pseudomonas RepID=Q4KDW8_PSEF5
          Length = 315

 Score =  113 bits (283), Expect = 9e-24,   Method: Compositional matrix adjust.
 Identities = 65/190 (34%), Positives = 101/190 (53%), Gaps = 9/190 (4%)

Query: 123 ICPIMVSFSVAAINSLMKQVALR-----ADFDFLTQVYSRSGLYEALKSPSLKQTQHLTV 177
           +C ++   +  AINSL  Q A +     +  D LTQ+Y+R    + L+    +    + +
Sbjct: 127 VCLVIYDLTDVAINSLALQKANQQLQHLSRTDHLTQLYNRGHWEQRLQFEYSRHGSSIAL 186

Query: 178 MLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVD 237
           ++LDID+FKSIND +GH+ GD V+   +  I + V D  +  R GGEEFA+ +P  +   
Sbjct: 187 LMLDIDHFKSINDRHGHQAGDAVIKRVSELIHQHVRDSDVAGRYGGEEFAILLPHTDLAG 246

Query: 238 GLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRS 297
              +AE++R+ VE Q      + +  T+S+G+    A       D   L+  AD  LY S
Sbjct: 247 ARTLAERLRQSVEEQEVIHNGQAIAFTISLGI----ACLDRPARDHRCLIEWADQALYAS 302

Query: 298 KKDGRNRTST 307
           K+ GRNR ST
Sbjct: 303 KRAGRNRVST 312


>UniRef50_C4KYJ1 Diguanylate cyclase n=1 Tax=Exiguobacterium sp. AT1b
           RepID=C4KYJ1_EXISA
          Length = 358

 Score =  113 bits (282), Expect = 9e-24,   Method: Compositional matrix adjust.
 Identities = 57/173 (32%), Positives = 101/173 (58%), Gaps = 8/173 (4%)

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGH 194
           IN  +K+  + A+ D LT + +R      +K    ++     V++LDID+FK IND YGH
Sbjct: 184 INHRVKEYKISAETDHLTGLENRRAWEMQMKKIK-ERYDTCNVLILDIDHFKQINDRYGH 242

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
             GD++L  F+  + +   D  + AR+GGEEF + +P ++  + + +AE+IR  +    F
Sbjct: 243 ANGDEILKQFSELLHRETRDHDIKARIGGEEFGILIPMLSQSEVIGVAERIRSSISKHAF 302

Query: 255 T-WQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
               Q+ ++++VSIG+ +G+      ++  ++++  AD CLY++K  GRNRT 
Sbjct: 303 KLLDQQVIHISVSIGIANGK------SEQLHEMVHLADDCLYQAKNSGRNRTH 349


>UniRef50_Q314F9 Diguanylate cyclase (GGDEF domain) n=1 Tax=Desulfovibrio
           desulfuricans subsp. desulfuricans str. G20
           RepID=Q314F9_DESDG
          Length = 542

 Score =  113 bits (282), Expect = 9e-24,   Method: Compositional matrix adjust.
 Identities = 62/180 (34%), Positives = 98/180 (54%), Gaps = 3/180 (1%)

Query: 130 FSVAAINSLMKQVALRADFDFLTQVYSRSGL-YEALKSPSLKQTQHL--TVMLLDIDYFK 186
           F    ++  M+ +   +  D LT +++R  L +E  ++ +      L  + ++LDID+FK
Sbjct: 350 FMAERVSQQMRDLEHLSFCDTLTGLHNRRHLAHEGTRTITACTEADLPCSCLMLDIDFFK 409

Query: 187 SINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIR 246
            +ND +GH+ GD VL   AR I   V  K +  RMGGEEFAV  P+ +      +AE+IR
Sbjct: 410 QVNDAWGHDAGDMVLQSVARTISNAVRSKDMTIRMGGEEFAVIAPATDTASAFSLAERIR 469

Query: 247 KGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
           + +E  P       + +T+SIGV     + +  T   + L+ +AD  LY++KK GRNRT 
Sbjct: 470 RNIESTPVQAADDEIRITISIGVADMGGAPIFGTTQLDDLLAKADRALYQAKKKGRNRTE 529


>UniRef50_A3WKT4 GGDEF domain protein n=2 Tax=Alteromonadales RepID=A3WKT4_9GAMM
          Length = 364

 Score =  113 bits (282), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 94/292 (32%), Positives = 141/292 (48%), Gaps = 33/292 (11%)

Query: 32  FKAEQMMPAIALIV------SVIASVVIGGAGSLAFPL----PALIWCAVRYTPQVTCLL 81
           F   + M AI+LI       S + +++IG      + L    PA I+ ++   P V  LL
Sbjct: 64  FGQRKNMLAISLIWLEVLYHSALGTLMIGWDSGFHYFLLMFVPA-IFVSMSLKPAVLTLL 122

Query: 82  TFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMK- 140
                 + + L        S   P   P   +A +G+    +  + + F   A+  L K 
Sbjct: 123 GLWVYYLSLDL-------FSWYYPAMQPINATAVVGVHIFNLTVVFIMFGYLALYYLNKV 175

Query: 141 -----QVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNY 192
                Q+   A  D LT++ +R  + E LK        + ++++V+LLD+D+FKS+ND +
Sbjct: 176 NLTHDQLRFYATTDPLTKLRNRRHMSELLKRALQNKHAEQRNVSVLLLDLDHFKSVNDTH 235

Query: 193 GHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQ 252
           GHE GDKVL + A  ++  V D   V+R GGEEF V +P  N      +AE+IRK +   
Sbjct: 236 GHEVGDKVLRITADILRDTVRDHDKVSRWGGEEFLVFLPRTNLNHAAQVAERIRKAIAKY 295

Query: 253 PF-TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           P+ T   + + LT SIGV     S L   D  N L+  AD  LYR K+ GRN
Sbjct: 296 PWHTVINENIQLTTSIGV-----SELKPDDSVNTLVKRADDALYRGKEAGRN 342


>UniRef50_A5P728 GGDEF domain protein n=1 Tax=Erythrobacter sp. SD-21
           RepID=A5P728_9SPHN
          Length = 243

 Score =  112 bits (281), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 68/196 (34%), Positives = 104/196 (53%), Gaps = 12/196 (6%)

Query: 116 LGIATMAICPIMVSFSVAA----INSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQ 171
           L +A   +C + V+  VA+    +  L +Q+A  A  D LT + +R   ++ +    L+ 
Sbjct: 40  LAVAIPLVCAVPVALVVASQAEVLARLNRQLAYEASHDALTDLPNRREFFDEIGR-RLES 98

Query: 172 TQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVP 231
               TV+L D+D FK +ND++GH  GD+ L   AR   + +   GLVAR+GGEEF V +P
Sbjct: 99  GGGGTVLLADVDRFKQVNDHHGHHTGDEALRALARLFAREIASDGLVARLGGEEFGVLIP 158

Query: 232 SVNPVDGLLMAEKIRKGVELQPFTWQQKTLY-LTVSIGVGSGRASYLTLTDDFNKLMVEA 290
             +   G  +AE++RK VE Q F   +   + LT+SIG+   R             +  A
Sbjct: 159 DTSLARGHEVAERLRKTVEAQDFHSPEGNRFPLTISIGIDCLRERESAYP------LRGA 212

Query: 291 DTCLYRSKKDGRNRTS 306
           D+ LY +K +GRNR S
Sbjct: 213 DSALYAAKSEGRNRVS 228


>UniRef50_C7LC06 GGDEF domain protein n=28 Tax=Brucella RepID=C7LC06_BRUMC
          Length = 264

 Score =  112 bits (281), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 61/164 (37%), Positives = 99/164 (60%), Gaps = 7/164 (4%)

Query: 141 QVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKV 200
           ++  RA  D +T + +R  L+EA+K  S  + +  T++++D D+FK+IND++GH  GD+ 
Sbjct: 77  ELQARARIDHMTGLLNREALFEAMK-ISRSRIETGTLLVIDADHFKAINDSFGHGVGDRA 135

Query: 201 LSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKT 260
           L + A  +Q +     LV R+GGEEF V +P  +   G+ +A++IR  VE  PF   +  
Sbjct: 136 LKLIAFALQNVTRKGDLVGRIGGEEFCVFLPGASGETGVRVAQRIRAEVENTPFHTTEYQ 195

Query: 261 LY-LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           +Y LT+SIGV S   S     +  ++++  AD CLY +K+ GRN
Sbjct: 196 VYPLTISIGVASAPKS-----ETNSQVLSRADRCLYLAKQRGRN 234


>UniRef50_B3R1Q4 Putative di-guanylate cyclase, GGDEF domain; transmembrane protein
           n=1 Tax=Cupriavidus taiwanensis RepID=B3R1Q4_CUPTR
          Length = 420

 Score =  112 bits (281), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 71/208 (34%), Positives = 106/208 (50%), Gaps = 9/208 (4%)

Query: 100 ISVGSPFSIPQMFSARLGI-ATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRS 158
           +S G+ +  P  +   L I    A+  + VSF++ A + L + +  RA  D LT V  R 
Sbjct: 185 MSQGAAWPRPLPWDGELAIFNVFALVGVSVSFALMAHDRLRRMLERRARHDDLTDVLLRG 244

Query: 159 GLYEALKSPSL---KQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDK 215
             +E L+   L   +Q + +TV  +D+D+FK+IND YGH  GD VL  FA  ++K +G  
Sbjct: 245 AFWEELEGACLQAERQRKPMTVAFVDLDHFKAINDVYGHLAGDSVLRHFAGLLRKTLGQG 304

Query: 216 GLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRAS 275
            L  R+GGEEFA+ +P      G L   ++   V   P   +   +  TVSIGV + +  
Sbjct: 305 HLAGRLGGEEFAIVMPDTALETGRLACLRLATAVRATPCPSEPDPIAYTVSIGVAARQPG 364

Query: 276 YLTLTDDFNKLMVEADTCLYRSKKDGRN 303
                +  + LM  AD  LY +K  GRN
Sbjct: 365 -----EGADALMRRADRALYDAKLKGRN 387


>UniRef50_A1ASG6 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Pelobacter
           propionicus DSM 2379 RepID=A1ASG6_PELPD
          Length = 505

 Score =  112 bits (280), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 72/186 (38%), Positives = 102/186 (54%), Gaps = 14/186 (7%)

Query: 125 PIMVSFSVAAINSLMK-QVALR--ADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVM 178
           P  +S   A I    + Q  LR  ++ D LT +Y+R  LY+ L     +  +H   LT+M
Sbjct: 309 PGTISVEFADITERTRMQEELREASERDPLTSLYNRRKLYQLLTVELTRTRRHGHPLTLM 368

Query: 179 LLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDG 238
           LLDID+FK IND +GH+ GD VL+  A  I  I+    ++AR GGEEF +A P  +    
Sbjct: 369 LLDIDHFKRINDTFGHDSGDLVLTQVAELISAILRSTDILARYGGEEFVIACPETDMDGA 428

Query: 239 LLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSK 298
            ++AEKIR  + +  F        +T+S+G+     S L   DD N L+  ADT LY +K
Sbjct: 429 AVLAEKIRSSIAMFSFP---TVGAVTISVGI-----SLLESKDDINALIKRADTALYAAK 480

Query: 299 KDGRNR 304
           + GRNR
Sbjct: 481 EMGRNR 486


>UniRef50_B5ZNS2 Diguanylate cyclase n=10 Tax=Rhizobiales RepID=B5ZNS2_RHILW
          Length = 392

 Score =  112 bits (279), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 62/171 (36%), Positives = 91/171 (53%), Gaps = 6/171 (3%)

Query: 144 LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV 203
           L A  D LT + +R  L++   +  +  T    V++ DID+FKS+ND +GH  GD+V+  
Sbjct: 219 LEAITDPLTGLLNRRALFDQYGTRPMGSTT--AVIVFDIDHFKSVNDRFGHASGDRVIKA 276

Query: 204 FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL 263
           FA  +        + AR+GGEEFA+ +    P    L AE+IR+  E +      + L  
Sbjct: 277 FAAELATHCRAGDIAARLGGEEFALVLKETMPGRAELAAERIRRAFEAREIEIDDEVLTC 336

Query: 264 TVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEV 314
           TVS+GV  GRA  L    DF+ ++  AD  LY +K+ GRNR     + E V
Sbjct: 337 TVSVGVAPGRAKSL----DFDAMLSAADKALYAAKRGGRNRVELAGHLEAV 383


>UniRef50_Q3SFG4 Putative diguanylate cyclase (GGDEF domain) n=1 Tax=Thiobacillus
           denitrificans ATCC 25259 RepID=Q3SFG4_THIDA
          Length = 570

 Score =  112 bits (279), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 65/165 (39%), Positives = 92/165 (55%), Gaps = 8/165 (4%)

Query: 146 ADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLS 202
           A  D LT + +R   Y    A  S +L+     +V+LLDID+FK IND YGH  GD VL 
Sbjct: 402 AQLDPLTGLNNRRAFYGMTAAAWSNALRHAHATSVLLLDIDHFKQINDRYGHAEGDAVLK 461

Query: 203 VFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY 262
             A  +++ V    ++AR GGEEF V +P     D  L+AE++R  +     T +  T+ 
Sbjct: 462 TVAGALKQSVRQGDVLARWGGEEFIVFLPETGLRDAALLAERLRVSIAALSVTGRVGTMA 521

Query: 263 LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
           +T SIGV   RA + TL    + L+  AD CL+ SK+ GRNR ++
Sbjct: 522 VTASIGVAE-RADHATL----DSLIAAADACLFASKQQGRNRVTS 561


>UniRef50_Q21ED1 GGDEF domain n=1 Tax=Saccharophagus degradans 2-40
           RepID=Q21ED1_SACD2
          Length = 476

 Score =  111 bits (278), Expect = 3e-23,   Method: Compositional matrix adjust.
 Identities = 62/164 (37%), Positives = 99/164 (60%), Gaps = 9/164 (5%)

Query: 145 RADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVF 204
           +A  D LT++Y+R G +E      ++Q + L++++LDID+FK +ND+YGH+ GD+VL  F
Sbjct: 302 QARLDPLTKIYNRRG-FEERAIQLMRQKRTLSLLILDIDHFKYVNDHYGHDIGDEVLRQF 360

Query: 205 ARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQ--PFTWQQKTLY 262
           ++ I  ++ D  + AR+GGEEFAV +   N     LMAE+IR  +E    P +    T+ 
Sbjct: 361 SKKIAGMIRDSDVFARIGGEEFAVILADQNLELAGLMAERIRATIESTELPVS-SDNTIK 419

Query: 263 LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
            TVSIGV S     ++   D ++ +   D  LY++K  GRN+ +
Sbjct: 420 YTVSIGVSS-----VSEGVDIHRWLKTTDKLLYQAKAQGRNQVA 458


>UniRef50_A6W0K6 Diguanylate cyclase n=1 Tax=Marinomonas sp. MWYL1
           RepID=A6W0K6_MARMS
          Length = 556

 Score =  111 bits (277), Expect = 4e-23,   Method: Compositional matrix adjust.
 Identities = 63/160 (39%), Positives = 93/160 (58%), Gaps = 12/160 (7%)

Query: 149 DFLTQVYSRSGLYEALKSPSLKQTQH----LTVMLLDIDYFKSINDNYGHECGDKVLSVF 204
           D LT +Y+R  L EAL     +Q Q       V+++D D+FK +ND++GH  GD VL   
Sbjct: 400 DPLTHIYNRLALDEALHK-EYRQAQESKCPFAVIMIDADHFKRVNDSFGHTVGDLVLQKI 458

Query: 205 ARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLT 264
           A+ +   VGDKG+VAR GGEEF V +P++N  +   +AE IR+ +E +  +     LY+T
Sbjct: 459 AKLLTVQVGDKGIVARFGGEEFTVLLPNMNADEAKNIAEMIREALEKEEMS---DGLYVT 515

Query: 265 VSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
            S GV    A Y      + +++  AD  LY++K+ GRNR
Sbjct: 516 ASFGV----AMYEIDDSHYEQVLNRADAALYKAKEQGRNR 551


>UniRef50_A4JR79 Diguanylate cyclase with PAS/PAC sensor n=4 Tax=Burkholderia
           RepID=A4JR79_BURVG
          Length = 432

 Score =  110 bits (276), Expect = 5e-23,   Method: Compositional matrix adjust.
 Identities = 61/132 (46%), Positives = 78/132 (59%), Gaps = 6/132 (4%)

Query: 175 LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVN 234
           L+V +LDIDYFK IND YGH+ GD+VL V A+    I  + GL AR GGEEF  A+P  +
Sbjct: 301 LSVFILDIDYFKKINDGYGHDIGDEVLRVLAKVGMSIPHESGLFARWGGEEFVAALPGAD 360

Query: 235 PVDGLLMAEKIRKGVELQPF--TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADT 292
             D   +AE +R+  E Q F   W+ K +  TVSIGV +  A       D + LM  AD 
Sbjct: 361 AADVRRIAETLRRRFEEQDFEHAWRVKPIQFTVSIGVVTREAG----ERDVDALMRRADR 416

Query: 293 CLYRSKKDGRNR 304
            LY +K+ GRNR
Sbjct: 417 ALYAAKESGRNR 428


>UniRef50_Q1LBF9 Diguanylate cyclase n=1 Tax=Cupriavidus metallidurans CH34
           RepID=Q1LBF9_RALME
          Length = 395

 Score =  110 bits (276), Expect = 5e-23,   Method: Compositional matrix adjust.
 Identities = 60/171 (35%), Positives = 99/171 (57%), Gaps = 6/171 (3%)

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLYE-ALKSPSLKQTQHLTVMLLDIDYFKSINDNYG 193
           I++L++++    D D LT++++R    E A ++ S        ++L+D+D+FK INDN+G
Sbjct: 211 IHALIERIQHERDTDALTRLHNRRSFEEIARETISRANGGVPGLILVDLDFFKLINDNHG 270

Query: 194 HECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP 253
           H  GD +L  FAR ++++VG +G+  R+GGEEFAV +P     + + +AE+IR  +E   
Sbjct: 271 HASGDAILVEFARIVRRVVGARGIAGRLGGEEFAVLLPRTTGEEAIHIAEEIRATLERAR 330

Query: 254 FTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           F     +  +T S GV   +       +  + LM  AD  LY +K+ GRNR
Sbjct: 331 FETLPDSPRVTASFGVAVWQPP-----ESLDALMSRADGLLYTAKRSGRNR 376


>UniRef50_Q1N653 Putative uncharacterized protein n=1 Tax=Bermanella marisrubri
           RepID=Q1N653_9GAMM
          Length = 378

 Score =  110 bits (276), Expect = 5e-23,   Method: Compositional matrix adjust.
 Identities = 60/168 (35%), Positives = 95/168 (56%), Gaps = 9/168 (5%)

Query: 146 ADFDFLTQVYSRSGLYEA---LKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLS 202
           A +D LT V++R G ++    L   +  ++ HL+VM++DID+FK +ND YGHE GD  L 
Sbjct: 203 ASYDPLTGVFNRRGFFDQWQILSKRTHDKSCHLSVMMIDIDHFKHVNDKYGHEAGDAALK 262

Query: 203 VFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY 262
             A  +   + +  ++ARMGGEEFAV +P        ++AE++R  +    F +  + + 
Sbjct: 263 WLADLLAHELRENDVLARMGGEEFAVMLPGCESSQAEIVAERLRNCIFKTRFVYLNQVIP 322

Query: 263 LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRY 310
           +T+S+G  +          D   L+V+AD  LY++K  GRNR   MRY
Sbjct: 323 ITISLGFITEDQP----ITDIKGLLVQADKGLYKAKDLGRNR--AMRY 364


>UniRef50_A4BIU7 Response regulator containing a CheY-like receiver domain and a
           GGDEF domain n=1 Tax=Reinekea blandensis MED297
           RepID=A4BIU7_9GAMM
          Length = 318

 Score =  110 bits (276), Expect = 5e-23,   Method: Compositional matrix adjust.
 Identities = 57/161 (35%), Positives = 94/161 (58%), Gaps = 7/161 (4%)

Query: 149 DFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LTQ+Y+R+   E L +   +Q +H   L++++ DID+FK +ND YGH+ GD V+   A
Sbjct: 159 DGLTQLYNRAYWEEMLSNEFKRQKRHAHDLSLIMFDIDHFKKVNDTYGHQVGDDVIRAVA 218

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
             ++    +  +  R GGEEFA+ +   +  + LL AE++RK +E +  +  +  L +TV
Sbjct: 219 EEVRHNSRNTDIAGRYGGEEFALLLIDSDAENALLFAERLRKAIENRRVSTPEGELQVTV 278

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
           S+GV   + S+      +N  +  AD  LY SK +GRNR++
Sbjct: 279 SLGVAPWKESF----HHYNAWIEAADKALYTSKDEGRNRST 315


>UniRef50_C6DJJ8 Diguanylate cyclase n=1 Tax=Pectobacterium carotovorum subsp.
           carotovorum PC1 RepID=C6DJJ8_PECCP
          Length = 480

 Score =  110 bits (275), Expect = 6e-23,   Method: Compositional matrix adjust.
 Identities = 83/322 (25%), Positives = 157/322 (48%), Gaps = 23/322 (7%)

Query: 5   WFSEQFSTGVLIVPCMLT----------LAIPGVLPRFKAEQMMPAIALIVSVIASVVIG 54
           WFSE+ S+GV+ V   L           ++   +   FK    +    +I+  IAS+ I 
Sbjct: 164 WFSEELSSGVIFVFLFLKVTRNVKNIFKISTSSIKKTFKKPLFILYPIIIIFCIASLNIT 223

Query: 55  GAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDI--SVGSPFSIPQMF 112
            +     PL   I+ ++ ++     L+   TG     +  N +I++  ++   +     +
Sbjct: 224 LSVLAILPL---IYLSLSHSFNKIILMCTATGIALNYIYINRLINVHDTIEKEYLFELSY 280

Query: 113 SARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEAL----KSPS 168
             ++  + + I  ++ SF +      +K++ L ++ D LT + +R  L + +     S  
Sbjct: 281 LFQINTSVIIITVLIASFFINKNRKNIKRIELISNHDALTGMLNRRSLNQHMMNIINSTR 340

Query: 169 LKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAV 228
               + +++++LDID+FK +ND YGH  GD V+  F+  +++    + L+ R GGEEF +
Sbjct: 341 DGDNKIMSLLVLDIDHFKKVNDTYGHAVGDNVIREFSTTLKQYTRPQDLLCRWGGEEFLI 400

Query: 229 AVPSVNPVDGLLMAEKIRKGVELQPFTWQQ-KTLYLTVSIGVGSGRASYLTLTDDFNKLM 287
            +  ++  D L +AE+IR  +E  P        +  T SIGV   +   L   +DF++  
Sbjct: 401 IIQGLSVNDCLDIAERIRSIIEGAPLAISDGHIVRCTTSIGVSFFQ---LERIEDFHEAF 457

Query: 288 VEADTCLYRSKKDGRNRTSTMR 309
            EAD  LY +K+ GRNR ++++
Sbjct: 458 KEADELLYMAKEQGRNRVNSVQ 479


>UniRef50_A6X0V6 Diguanylate cyclase n=3 Tax=Brucellaceae RepID=A6X0V6_OCHA4
          Length = 263

 Score =  110 bits (275), Expect = 6e-23,   Method: Compositional matrix adjust.
 Identities = 59/164 (35%), Positives = 98/164 (59%), Gaps = 7/164 (4%)

Query: 141 QVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKV 200
           ++  R+  D +T + +R  L+EA+K  S  + +  T++++D D+FK+IND +GH  GD+ 
Sbjct: 78  ELQARSRIDHMTGLLNREALFEAMK-ISRSRIETGTLLVIDADHFKAINDTFGHGVGDRA 136

Query: 201 LSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKT 260
           L + A  +Q +     LV R+GGEEF V +P  +   G+ +A++IR  VE  PF   +  
Sbjct: 137 LKLIAFALQNVTRKGDLVGRIGGEEFCVFLPGASGETGMRVAQRIRAEVENTPFHTTEYQ 196

Query: 261 LY-LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           +Y LT+SIGV S   +     +  ++++  AD CLY +K+ GRN
Sbjct: 197 VYPLTISIGVASAPKN-----ETNSQVLSRADRCLYIAKQRGRN 235


>UniRef50_UPI0001787F83 diguanylate cyclase with PAS/PAC sensor n=1 Tax=Geobacillus sp.
           Y412MC10 RepID=UPI0001787F83
          Length = 539

 Score =  110 bits (275), Expect = 6e-23,   Method: Compositional matrix adjust.
 Identities = 69/202 (34%), Positives = 107/202 (52%), Gaps = 17/202 (8%)

Query: 126 IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYE---ALKSPSLKQTQHLTVMLLDI 182
           ++V   V     L +++   A +D LT++Y+RS   +   AL + +++  + L  +L DI
Sbjct: 340 LIVLIDVTDKARLQEELRQMAYYDGLTRIYNRSHFMKLSYALLNQAVRNREPLAFLLFDI 399

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           D+FK IND YGH+ GD+ L       +K +  + L AR GGEEFAVA+P  +  +    A
Sbjct: 400 DHFKRINDVYGHDIGDQALQHIVELTRKTLRAEDLFARYGGEEFAVAMPGQSTSEATAAA 459

Query: 243 EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDD-----------FNKLMVEAD 291
           E+IR  +  QP T  Q +L +T S GV + + S    T D             K++ +AD
Sbjct: 460 ERIRAKLLAQPMTTPQGSLMITASFGVAAVKTSSHNGTVDAEAEEAWWDTELKKVLKQAD 519

Query: 292 TCLYRSKKDGRNRTSTMRYGEE 313
             LY +K+ GRN   T+R  +E
Sbjct: 520 RALYEAKRSGRN---TIRVSDE 538


>UniRef50_B6BJC6 GGDEF domain/pas/pac sensor domain protein n=1
           Tax=Campylobacterales bacterium GD 1 RepID=B6BJC6_9PROT
          Length = 396

 Score =  110 bits (275), Expect = 7e-23,   Method: Compositional matrix adjust.
 Identities = 64/164 (39%), Positives = 92/164 (56%), Gaps = 13/164 (7%)

Query: 146 ADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLS 202
           A FD LT +Y+R    E LK  +++  ++   L+ +  DID+FK++ND YGH+ GD+VL 
Sbjct: 239 AYFDNLTGIYNRRKFDEILKIETIRVHRYKRKLSALFFDIDHFKNVNDTYGHDTGDEVLK 298

Query: 203 VFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ-QKTL 261
             +  IQ    D    AR GGEEF + +P  N ++  LMAEKIRK +    F++   K  
Sbjct: 299 KMSNIIQLHTRDTDYFARWGGEEFILLLPETNVLEANLMAEKIRKTI----FSYDFNKVG 354

Query: 262 YLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
            LT+SIGV   +    + T      +   D  LY++K DGRNRT
Sbjct: 355 NLTISIGVSELKEKERSST-----FLKRLDKALYKAKNDGRNRT 393


>UniRef50_A4BG19 GGDEF domain protein n=1 Tax=Reinekea blandensis MED297
           RepID=A4BG19_9GAMM
          Length = 377

 Score =  110 bits (274), Expect = 8e-23,   Method: Compositional matrix adjust.
 Identities = 63/176 (35%), Positives = 94/176 (53%), Gaps = 8/176 (4%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKS 187
           S   +N L +    +A  D LT + +R G+ E ++     S +  Q +T +L D+D+FK 
Sbjct: 192 SYQKLNELKQDFERQASQDTLTHLLNRRGMRERIRYEVRRSQRNNQPITFILADLDHFKE 251

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           IND+YGH+ GD VL   ++ +Q  V  +  +AR GGEEF   +P  N    + +AEKIR 
Sbjct: 252 INDHYGHDTGDTVLIQVSQLLQDSVRQQDSIARWGGEEFLFLLPETNARQAMQLAEKIRS 311

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
            +E  P    Q  L  T+S G+    A  L L ++    + EAD  LY++K  GRN
Sbjct: 312 IIESHPLNSDQPPLTTTMSFGI----AEMLDL-ENHQSTIAEADNRLYQAKSQGRN 362


>UniRef50_Q0K903 GGDEF domain protein n=3 Tax=Cupriavidus RepID=Q0K903_RALEH
          Length = 419

 Score =  110 bits (274), Expect = 8e-23,   Method: Compositional matrix adjust.
 Identities = 71/216 (32%), Positives = 107/216 (49%), Gaps = 9/216 (4%)

Query: 103 GSPFSIPQMFSARLGIATM-AICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY 161
           G  +  P  +   L +  + A+  + VSF++ A + L + +  RA  D LT V  R   +
Sbjct: 188 GGAWPRPMPWDGELAMLNIFALVGVSVSFALMAHDRLRRMLERRARHDDLTDVLLRGAFW 247

Query: 162 EALKSPSLK---QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLV 218
           E L++  L+   Q + LTV  +D+D+FK+IND YGH  GD VL  FA  ++K  G   + 
Sbjct: 248 EELEAACLRAERQRKPLTVAFVDLDHFKAINDVYGHLAGDSVLRHFAGQLRKNFGQLEVA 307

Query: 219 ARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLT 278
            R+GGEEFA+ +P      G L   ++   V   P   +   +  TVSIG+ + +     
Sbjct: 308 GRLGGEEFAILMPDTALEQGRLACLRLATAVRATPCPSEPDPIAYTVSIGLAARQPG--- 364

Query: 279 LTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEV 314
             +  + LM  AD  LY +K  GRN  S    G E 
Sbjct: 365 --EGADALMRRADRALYDAKLKGRNCVSLHPAGSEA 398


>UniRef50_B5ZQ84 Diguanylate cyclase n=5 Tax=Rhizobium RepID=B5ZQ84_RHILW
          Length = 385

 Score =  110 bits (274), Expect = 9e-23,   Method: Compositional matrix adjust.
 Identities = 64/174 (36%), Positives = 99/174 (56%), Gaps = 9/174 (5%)

Query: 140 KQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDK 199
            Q+   A  D LT   +R GL + L  P+L  +Q ++++++DID+FK +ND +GH  GD 
Sbjct: 217 NQLTELAHHDPLTGALNRGGLAQRL--PALG-SQPVSLLIIDIDHFKQLNDRHGHASGDD 273

Query: 200 VLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQK 259
           +L +FA   + I+G   L+AR GG+EF V +  V+  D + +AE+IR             
Sbjct: 274 ILRLFASVSRSIMGSNDLLARQGGDEFLVVLKDVSGQDAVAIAERIRLAFAAAVLHQPDL 333

Query: 260 TLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEE 313
            ++ T+SIGV +   S      DF +L+ +AD  LYRSK++GRNR     +GE 
Sbjct: 334 AVFPTLSIGVATRGKS----GGDFEQLIKKADEALYRSKREGRNRVKA--FGEN 381


>UniRef50_A4SQK1 GGDEF domain protein n=2 Tax=Aeromonas RepID=A4SQK1_AERS4
          Length = 539

 Score =  109 bits (273), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 63/162 (38%), Positives = 93/162 (57%), Gaps = 8/162 (4%)

Query: 148 FDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVF 204
            D LTQV++R+ L E L+      L+    L + ++DID+FK+INDNYGH  GDK L V 
Sbjct: 381 LDSLTQVHNRAALDERLELEYKRWLRYNTPLCLAIIDIDHFKNINDNYGHMAGDKALKVV 440

Query: 205 ARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLT 264
           A+ +Q  + D   +AR GGEEF V +P++NP       E +R+ ++  PF ++   + +T
Sbjct: 441 AKALQGALRDTDFIARFGGEEFVVLLPNINPDKYQKPLETLRQTIKSIPFRFRDARVEIT 500

Query: 265 VSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
           +SIG    R    T TD F +    AD  LY SK  GR++ +
Sbjct: 501 ISIGATLFREGDHT-TDAFER----ADKALYSSKHSGRDQVN 537


>UniRef50_A6F836 Putative uncharacterized protein n=1 Tax=Moritella sp. PE36
           RepID=A6F836_9GAMM
          Length = 325

 Score =  109 bits (273), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 65/183 (35%), Positives = 103/183 (56%), Gaps = 12/183 (6%)

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH----LTVMLLDIDYFKSIND 190
           + +L K++  RA  D LT + +R   YE +        QH    LT++L+DID FK IND
Sbjct: 135 LQALTKELHTRASTDELTVISNRRNFYE-MAEIEFINAQHGQKPLTLLLIDIDNFKIIND 193

Query: 191 NYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVE 250
           ++GH  GD VL  FA++I+  +    +  R+GG+EFA+ +P+ +  + L +AE  R  + 
Sbjct: 194 SFGHAAGDMVLKAFAQNIKTELRSGDIFGRLGGDEFAILLPNTDCNESLPLAELFRNTIA 253

Query: 251 LQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN---RTST 307
                 +++ L LT SIG+    A+  ++    + +M  ADT LY++K  GRN   R ST
Sbjct: 254 KMKIDHKEQHLQLTASIGIVQSSAAMQSI----HAMMNAADTALYQAKSAGRNTVCRCST 309

Query: 308 MRY 310
           M+Y
Sbjct: 310 MQY 312


>UniRef50_C7R6Y0 Diguanylate cyclase n=1 Tax=Kangiella koreensis DSM 16069
           RepID=C7R6Y0_KANKD
          Length = 469

 Score =  109 bits (273), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 63/177 (35%), Positives = 99/177 (55%), Gaps = 10/177 (5%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVMLLDIDYFKS 187
            + A+N  ++++A     D LT+V +R       E   S S + +  L +M++D D+FK 
Sbjct: 288 ELKAVNQKLEELAAT---DSLTRVANRREFMKRSEEEMSRSSRNSTDLCLMVIDFDHFKE 344

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           IND YGH+ GDKVL  F +  ++++    L+ R+GGEEFA+ +P  N    + +AE++R+
Sbjct: 345 INDQYGHQAGDKVLKDFVKLAKEVMRPSDLLGRIGGEEFALLLPETNIRSAVKVAERLRQ 404

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
            +E +      K + LT+SIGV    A Y    D   K +  AD  LY++K  GRNR
Sbjct: 405 HIEEESIVIGSKRIKLTISIGV----AEYQPKVDTVKKWLHRADEFLYQAKDKGRNR 457


>UniRef50_A1T013 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Psychromonas
           ingrahamii 37 RepID=A1T013_PSYIN
          Length = 406

 Score =  109 bits (273), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 63/172 (36%), Positives = 94/172 (54%), Gaps = 14/172 (8%)

Query: 140 KQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDK 199
           K++A +A  D LT +Y+R  +Y+ +     K    ++ ML+D+D FK +ND YGH  GD 
Sbjct: 243 KRLAHKAFHDSLTDLYNRDAIYKWIHEHCGK-VNSMSCMLIDLDNFKRVNDTYGHSKGDN 301

Query: 200 VLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQK 259
           VL +FA   ++ + +KG++ R GGEEF V VP  +    L +AEK+R      P   Q K
Sbjct: 302 VLKIFANLFKEKIAEKGVIGRWGGEEFIVFVPDRDKKTALALAEKVRIACAQTPLFLQGK 361

Query: 260 TLYLTVSIGVGSGRASYLTLTDDF-----NKLMVEADTCLYRSKKDGRNRTS 306
            +  TVSIGV        + TD F       ++ +AD  +Y SK  G+NR +
Sbjct: 362 EIITTVSIGV--------SYTDSFAQIKPKDIIKQADHNMYLSKSLGKNRVT 405


>UniRef50_C0QSJ8 Diguanylate cyclase/phosphodiesterase n=1 Tax=Persephonella marina
           EX-H1 RepID=C0QSJ8_PERMH
          Length = 621

 Score =  109 bits (273), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 73/191 (38%), Positives = 104/191 (54%), Gaps = 16/191 (8%)

Query: 116 LGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHL 175
           LG+AT  +  +   F     + ++KQ   RA  D LT V++R+ L E      LK     
Sbjct: 195 LGLATFTVITLFFIFYYFIKSFILKQ---RAYTDSLTGVFNRNYLEEITDVIDLKD---Y 248

Query: 176 TVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSV-- 233
            VML+DID+FK IND YGHE GD+VLS FA  I++ +    ++ R GGEEF V + +   
Sbjct: 249 IVMLVDIDHFKRINDTYGHEIGDRVLSKFAELIKQNLRRDDIIIRYGGEEFLVLLKNYRK 308

Query: 234 NPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTC 293
              D L +AE++   +E   F+     + +TVSIG+         LTD   K    ADT 
Sbjct: 309 QKKDSLKVAERLMDTIENTEFSG----IRITVSIGINMDTDKSRNLTDAIKK----ADTA 360

Query: 294 LYRSKKDGRNR 304
           LY++K++GRNR
Sbjct: 361 LYKAKREGRNR 371


>UniRef50_D2R798 Diguanylate cyclase n=1 Tax=Pirellula staleyi DSM 6068
           RepID=D2R798_9PLAN
          Length = 500

 Score =  109 bits (273), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 66/165 (40%), Positives = 91/165 (55%), Gaps = 10/165 (6%)

Query: 143 ALRADFDFLTQVYSRSGLYEALKSPSLKQTQH----LTVMLLDIDYFKSINDNYGHECGD 198
           A+ A  D LTQV +R    + L+   L +  H     T+M+LD+D+FK  ND +GH+ GD
Sbjct: 118 AVEARTDALTQVANRRAFDDELRR-CLSERDHNKTVSTLMILDVDHFKKFNDTHGHQAGD 176

Query: 199 KVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQ 258
           +VL   AR ++       LVAR GGEEFA+  P V+     + AEK R+ V    F +Q 
Sbjct: 177 EVLRGVARVLRNAFSSAELVARYGGEEFAIVFPGVSFAACQISAEKARQAVATANFRFQG 236

Query: 259 KTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           K+L +T S G+     S L  TD+  + +  AD  LY SKK GRN
Sbjct: 237 KSLSVTASAGL-----SELLPTDNEQEWIRRADEALYASKKAGRN 276



 Score = 43.1 bits (100), Expect = 0.012,   Method: Compositional matrix adjust.
 Identities = 29/129 (22%), Positives = 60/129 (46%), Gaps = 5/129 (3%)

Query: 175 LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVN 234
           L++M++ +D    +   +G      VL V ++ +Q  + D   V R+G + FA+ +P   
Sbjct: 357 LSLMMVQVDGLMRVATEHGPTAAATVLRVTSQIMQATMRDMDHVTRLGEDTFALLLPGAK 416

Query: 235 PVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCL 294
            +D   ++E++R  V+      +    + T+++G     A  ++  DD   ++  A   L
Sbjct: 417 IIDAHSVSERLRAAVQKCRLPRRAGAAWFTITVG-----AVEVSNGDDMRLILERARRAL 471

Query: 295 YRSKKDGRN 303
             +   GRN
Sbjct: 472 QAAIAQGRN 480


>UniRef50_B9JVD4 GGDEF family protein n=1 Tax=Agrobacterium vitis S4
           RepID=B9JVD4_AGRVS
          Length = 420

 Score =  109 bits (272), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 63/168 (37%), Positives = 92/168 (54%), Gaps = 7/168 (4%)

Query: 149 DFLTQVYSRSGLYEALKS--PSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFAR 206
           D LT   +R GL E +     ++ + + L +++ D+DYFK IND +GH+ GD VLS FA+
Sbjct: 219 DPLTGALNRRGLIETVGELKHTVARDRLLALLVFDLDYFKHINDTFGHQAGDTVLSSFAQ 278

Query: 207 HIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVS 266
                +G+  + AR GGEEF   +   +      +AE+IR  +   P T +Q  + LT S
Sbjct: 279 MTGGALGNDAIFARSGGEEFCAVMAVADLRQAAGVAERIRYMIASTPITTEQGVVRLTTS 338

Query: 267 IGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEV 314
           IG+ +          DF+  M +AD  LY +K DGRNRT+  R GE V
Sbjct: 339 IGLSAATVEAF----DFDTAMRQADHGLYTAKADGRNRTAVAR-GETV 381


>UniRef50_D0LIN2 Diguanylate cyclase n=1 Tax=Haliangium ochraceum DSM 14365
           RepID=D0LIN2_HALO1
          Length = 364

 Score =  109 bits (272), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 69/169 (40%), Positives = 99/169 (58%), Gaps = 9/169 (5%)

Query: 138 LMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGH 194
           LM++ ALR   D LTQ Y++    E L S    + +  + L+++L+D+D FK IND YGH
Sbjct: 138 LMQESALR---DGLTQAYNKRYFSERLDSEVRFAQRHKEPLSLLLMDLDGFKQINDRYGH 194

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
             GD+VL  FAR +Q+ + ++ + AR GGEEFAV   S++  D L MAE++R        
Sbjct: 195 IAGDQVLHAFARAVQRSIRNEDVFARYGGEEFAVLSRSISVEDALSMAERLRALTAELTV 254

Query: 255 TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
            +Q + + LTVSIGV S     L +  D  +L+  AD  LY +K  GRN
Sbjct: 255 EFQNRRIGLTVSIGVAS--VPELQVA-DCTELLGAADRALYWAKAHGRN 300


>UniRef50_Q88RK0 GGDEF domain protein n=3 Tax=Pseudomonas putida RepID=Q88RK0_PSEPK
          Length = 645

 Score =  109 bits (272), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 62/169 (36%), Positives = 98/169 (57%), Gaps = 11/169 (6%)

Query: 139 MKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGHE 195
            +Q AL    D LT + +R+   E ++   L   +   HL + +LD+D+FK INDNYGH 
Sbjct: 481 QRQKAL---LDPLTGLPNRAAWSERVEREMLDWQENGGHLAMAILDLDHFKRINDNYGHL 537

Query: 196 CGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFT 255
            GDKVL + A  ++K +  +  +AR GGEEF + +P   P     +AE +R  VE  PF 
Sbjct: 538 AGDKVLKIVADQLRKRLRGRDFIARFGGEEFVMLLPQTTPAVAAQVAEVLRATVEACPFH 597

Query: 256 WQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           ++ + + +T SIG+G+ R+   +     ++++  AD  LYR+K+ GRNR
Sbjct: 598 FKGERVVITTSIGLGAFRSGERS-----DQVLKRADAALYRAKELGRNR 641


>UniRef50_A6UB49 Diguanylate cyclase n=2 Tax=Sinorhizobium RepID=A6UB49_SINMW
          Length = 438

 Score =  109 bits (272), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 60/164 (36%), Positives = 89/164 (54%), Gaps = 8/164 (4%)

Query: 149 DFLTQVYSRSGLYEA---LKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LT   SR  L E    + +  L + +    +LLD+D+FK IND YGH CGD  L+ FA
Sbjct: 248 DGLTGALSRGALMEEGEQIFAECLTRRRPAAFLLLDLDFFKQINDQYGHACGDMALAHFA 307

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
             +   +  +G++ R+GGEEF + +P         +AE+I + V   P     + + LTV
Sbjct: 308 DTVSTFLAGRGVLGRIGGEEFGIVLPDHTEEQAKALAEEICRIVRETPAGRSHQRIRLTV 367

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
           SIG+ +  A + T+ D    +M+ AD  LY SK DGR+R +  R
Sbjct: 368 SIGIAAATA-HETIAD----VMIRADLALYDSKADGRDRCTIAR 406


>UniRef50_C7LVZ4 Diguanylate cyclase n=1 Tax=Desulfomicrobium baculatum DSM 4028
           RepID=C7LVZ4_DESBD
          Length = 483

 Score =  109 bits (272), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 81/290 (27%), Positives = 137/290 (47%), Gaps = 30/290 (10%)

Query: 23  LAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLT 82
           L +PG LP  +  + +  +  + + +    + G    A  L     C     P++  L+T
Sbjct: 201 LFLPGTLPHAQQAEWINHLLSVAARLGKQEVRGYQVSALELKD---CKPGNPPELEELIT 257

Query: 83  FVTGAVEIVLVANSVIDISVGS-PFS---IPQMFSARLGIATMAICPIMVS-FSVAAINS 137
                          + +++GS PF    I    +++LG   + I     +  ++A  N 
Sbjct: 258 ---------------LPLTLGSEPFGALVICSQDASKLGQDRLRILSSAANHLALAMRNG 302

Query: 138 L-MKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYG 193
           L  ++   RAD D LT++ +R      L+    +  +H   L++M++D+DYFKSIND YG
Sbjct: 303 LEFRKTKARADHDGLTRISNRHHFDIRLREEMKRHQRHQDELSLMMIDLDYFKSINDTYG 362

Query: 194 HECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP 253
           H+ GD VL    + +   + +    AR GGEEF V +P        ++AE++R  +    
Sbjct: 363 HQAGDMVLQEVGKILNNTLRESDFPARYGGEEFVVILPQTREDQAWILAERLRSQIGQTF 422

Query: 254 FTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           F  Q+K   +T SIG+   +   LT  +    L+  ADT LY++K +GRN
Sbjct: 423 FRSQKKRFRVTASIGIAGIKPCALTPPE---TLLRNADTALYQAKTNGRN 469


>UniRef50_A6F6I7 Hypothetical GGDEF domain family protein n=1 Tax=Moritella sp. PE36
           RepID=A6F6I7_9GAMM
          Length = 505

 Score =  109 bits (272), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 60/161 (37%), Positives = 93/161 (57%), Gaps = 9/161 (5%)

Query: 148 FDFLTQVYSRSGLYEALKSPSLKQTQ----HLTVMLLDIDYFKSINDNYGHECGDKVLSV 203
            D LTQVY+R+ L E  K    K+ Q    + T+ ++DID+FK+IND++GH  GDK L +
Sbjct: 345 LDSLTQVYNRTALDERFK-LEFKRWQRYKTNTTIAMVDIDHFKNINDSFGHIAGDKALKI 403

Query: 204 FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL 263
            AR +QK +     +AR GGEEF + +  V P +  +M +K+R  ++  PF ++ K + +
Sbjct: 404 VARALQKSIKSSDFIARFGGEEFVLLLADVAPSEIQVMLDKLRNTIKNIPFRFKGKQISI 463

Query: 264 TVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           T+SIGV         + D F +    AD  LY +K  GR++
Sbjct: 464 TISIGVTQFSLDDNEIVDPFER----ADKALYEAKSSGRDK 500


>UniRef50_A6SZ23 Uncharacterized conserved protein n=1 Tax=Janthinobacterium sp.
           Marseille RepID=A6SZ23_JANMA
          Length = 417

 Score =  109 bits (272), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 57/188 (30%), Positives = 103/188 (54%), Gaps = 13/188 (6%)

Query: 120 TMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LT 176
           TM +  +M++      ++++  +   A+ D LT+  SR  L    +   L+  +    L+
Sbjct: 223 TMTMAAVMLTH-----DAMLANLEDAANHDHLTEALSRKRLEAVAREQILRAGKFGRPLS 277

Query: 177 VMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPV 236
           ++++D+D+FK IND YGH  GD+VL  FAR  +  + D   + R+GGEEF + +P+ + V
Sbjct: 278 LLIIDLDHFKRINDTYGHAGGDEVLREFARMTRASLRDGDALGRLGGEEFGILLPNTDTV 337

Query: 237 DGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYR 296
             L +A ++R+  E    +      + ++SIG+ + R       ++F++L + AD  LY 
Sbjct: 338 GALAIARRLREDSERHLISGTFGECHYSISIGIATWRDG-----ENFDRLSIRADRALYT 392

Query: 297 SKKDGRNR 304
           +K  GRNR
Sbjct: 393 AKNSGRNR 400


>UniRef50_Q47X90 GGDEF domain protein n=1 Tax=Colwellia psychrerythraea 34H
           RepID=Q47X90_COLP3
          Length = 364

 Score =  108 bits (271), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 61/183 (33%), Positives = 104/183 (56%), Gaps = 10/183 (5%)

Query: 131 SVAAINSLMKQV---ALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDY 184
           SV A +SL K V      +  D LT +Y+R   +E  K   + + ++ + +++++LDID 
Sbjct: 186 SVEANDSLEKSVNELHRLSIMDNLTNIYNRRYFFEMSKKLIATAFREQKPVSLIMLDIDL 245

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEK 244
           FK +NDNYGH+ GD +L    + ++K++    + AR+GGEEF + + + +     ++AEK
Sbjct: 246 FKRVNDNYGHQAGDCILIDLVKELEKVMRKSDVFARIGGEEFTILLNNTSLEGAKVIAEK 305

Query: 245 IRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           +R  +E + F +   ++ +T+SIGV        ++ D    L  +AD  LYR+K  GRNR
Sbjct: 306 MRLTIENKVFIYNTTSIDITISIGVSELNTENTSIED----LYKQADKQLYRAKHKGRNR 361

Query: 305 TST 307
             T
Sbjct: 362 VCT 364


>UniRef50_Q2RRD4 Putative diguanylate cyclase (GGDEF domain) n=1 Tax=Rhodospirillum
           rubrum ATCC 11170 RepID=Q2RRD4_RHORT
          Length = 686

 Score =  108 bits (271), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 63/186 (33%), Positives = 107/186 (57%), Gaps = 9/186 (4%)

Query: 126 IMVSFS-VAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLD 181
           +  SF+ ++   +L +++   A+ D LT + +R  + +AL+S   + T++   L+VM+LD
Sbjct: 493 VFASFNDISQTKALERELRALAERDSLTGLANRLRVMDALRSEFDRVTRYGGALSVMMLD 552

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           +D FK +ND +GH CGD+ L  FA      +    L+ R GGEEF V +P        L+
Sbjct: 553 LDRFKVLNDRHGHVCGDEALRHFAASALATLRTNDLLGRSGGEEFIVLLPGAALGAAKLI 612

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
            E++R  V+ +P +WQ +++ L+VSIG+ S +     + D  + L+  AD  L+ +K +G
Sbjct: 613 GERLRAAVQDKPLSWQGRSVALSVSIGLASRQ-----IGDTPDSLLGRADQALHLAKANG 667

Query: 302 RNRTST 307
           RNR  T
Sbjct: 668 RNRLET 673


>UniRef50_B7GHV8 Signal transduction diguanylate cyclase n=1 Tax=Anoxybacillus
           flavithermus WK1 RepID=B7GHV8_ANOFW
          Length = 363

 Score =  108 bits (270), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 59/173 (34%), Positives = 95/173 (54%), Gaps = 8/173 (4%)

Query: 136 NSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNY 192
             +++     A  DFLT +Y+    +  L+    K  +    L ++L DID FK +ND+Y
Sbjct: 185 KEMLQHYKAWATTDFLTGLYNVRQFHALLRENIAKANEQQSCLALILFDIDRFKCVNDSY 244

Query: 193 GHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQ 252
           GH+ GD +L      I+ +V   G   R GGEEF++ +P+    + +  AE IR  +E  
Sbjct: 245 GHDGGDVILRHLGELIRSLVPKNGFSFRNGGEEFSILLPTCER-EAMAFAEHIRTTIEQH 303

Query: 253 PFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
            F  QQ+T+++T+SIG+    + + TL  +  +L  +AD  LY +K+ GRNRT
Sbjct: 304 SFFVQQQTVHITISIGI----SVFPTLATNEPELFKQADIALYEAKQQGRNRT 352


>UniRef50_Q1MYJ5 Response regulator containing a CheY-like receiver domain and a
           GGDEF domain n=1 Tax=Bermanella marisrubri
           RepID=Q1MYJ5_9GAMM
          Length = 642

 Score =  108 bits (270), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 60/163 (36%), Positives = 98/163 (60%), Gaps = 9/163 (5%)

Query: 149 DFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LT++++R    +  +S   +  +H   + +++LDID+FK +NDN+GH  GD  L   A
Sbjct: 475 DALTKIHNRYFFDQHWRSEFKRAHRHKMSIALIILDIDHFKKVNDNFGHPAGDLCLQKVA 534

Query: 206 RHIQ-KIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLT 264
           + I+ +   +  LV R+GGEEFAV +P  + +    +AEKIR  +E +  +W+ KT+ +T
Sbjct: 535 QSIRIQANRESDLVCRLGGEEFAVILPGTDEMGAYEVAEKIRHTIEKRHISWEGKTIKIT 594

Query: 265 VSIGVG--SGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
           VSIG+   + R S   +    N +  +AD  LY++K +GRNRT
Sbjct: 595 VSIGISAMTPRKSDEKMR---NIMFNQADQALYQAKGNGRNRT 634


>UniRef50_Q1N175 Diguanylate cyclase (GGDEF domain) n=1 Tax=Bermanella marisrubri
           RepID=Q1N175_9GAMM
          Length = 294

 Score =  108 bits (270), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 69/204 (33%), Positives = 109/204 (53%), Gaps = 18/204 (8%)

Query: 116 LGIATMAICPIMVSFSVAAINSLMKQVALRADF-------DFLTQVYSRSGLYEALKSPS 168
           LG     I P  +S  +A + S +++   R D        D LT +Y+R   +E  +   
Sbjct: 97  LGAVDYVIKPYSLSVLLARVRSALREKE-RLDLMEKWATTDPLTGLYNRRFFFEQAQR-E 154

Query: 169 LKQTQH----LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGE 224
           L++ Q      + ++LDID+FK +ND YGH  GD VL   A+  ++      L  R GGE
Sbjct: 155 LERVQRNETDASFIILDIDHFKKVNDEYGHLVGDDVLEGLAKLFKETFRKVDLCCRFGGE 214

Query: 225 EFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFN 284
           EF + +P  +    LL+AE+ RK VE   F  ++  L++T+S+GV S   +  TL D   
Sbjct: 215 EFVICLPDTDTEGALLVAERTRKKVEELSFNTEKGPLHVTISLGVSSANENT-TLED--- 270

Query: 285 KLMVEADTCLYRSKKDGRNRTSTM 308
            ++  AD  LY++K++GRNRT ++
Sbjct: 271 -MLKRADDALYQAKQNGRNRTESL 293


>UniRef50_A0LAY9 Diguanylate cyclase n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0LAY9_MAGSM
          Length = 220

 Score =  108 bits (270), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 64/186 (34%), Positives = 104/186 (55%), Gaps = 9/186 (4%)

Query: 123 ICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVML 179
           I  ++ ++ + ++   ++Q+ + A  D LT + +R G  E  K     S + +  L V++
Sbjct: 29  IISLVGAWLIYSLRKALQQLEVMATHDKLTGILNRHGFQERGKYIIDQSQRHSWPLAVVM 88

Query: 180 LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGL 239
           +DID+FK IND++GH+ GD VL      ++K V    +VAR+GGEEFA+ +P+ +     
Sbjct: 89  MDIDHFKKINDSFGHDIGDLVLQSLGSELKKSVRSTDIVARLGGEEFALILPNTDSKHAH 148

Query: 240 LMAEKIRKGVELQPFTW-QQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSK 298
            +A+ IRK +E    +    K L  T+S+GV SG        D  + L+ +AD  LYR+K
Sbjct: 149 QIADSIRKKIETSRLSLPDGKFLTYTLSLGVTSGLG-----IDKMDLLLNQADNALYRAK 203

Query: 299 KDGRNR 304
             GRNR
Sbjct: 204 GTGRNR 209


>UniRef50_B0TJ24 Periplasmic/7TM domain sensor diguanylate cyclase n=4
           Tax=Shewanella RepID=B0TJ24_SHEHH
          Length = 623

 Score =  108 bits (270), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 63/181 (34%), Positives = 102/181 (56%), Gaps = 7/181 (3%)

Query: 128 VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDY 184
           +  ++  +N   +++  +   D LT V +R+     + +    S +Q   L++++LDID 
Sbjct: 437 LEIALRELNEANQKLTEQTRIDSLTGVKNRASFDRRILAEGRISRRQQAPLSILMLDIDR 496

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIVGD-KGLVARMGGEEFAVAVPSVNPVDGLLMAE 243
           FK IND+YGH  GD+ L V A  +++I+     LV+R GGEEFA+ +P+ + +    +AE
Sbjct: 497 FKLINDSYGHLAGDQALRVIADQLKQILKRPTDLVSRFGGEEFAIILPNTDKIGAQQVAE 556

Query: 244 KIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
            IRK +   P  W    + LTVSIGV S     +T  +    L+ +AD  LY++K DGRN
Sbjct: 557 TIRKVISKLPICWGGNRIRLTVSIGVSS---EIITSEEHTTLLLEQADKALYQAKNDGRN 613

Query: 304 R 304
           +
Sbjct: 614 Q 614


>UniRef50_Q7MRL2 Putative uncharacterized protein n=1 Tax=Wolinella succinogenes
           RepID=Q7MRL2_WOLSU
          Length = 480

 Score =  108 bits (270), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 83/294 (28%), Positives = 136/294 (46%), Gaps = 30/294 (10%)

Query: 21  LTLAIPGVLPRFKAEQMMPAIAL--IVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVT 78
           L LA+ G +   K E     + L  I+ V+ S            L  L    + Y  ++T
Sbjct: 201 LDLALSGRIAVDKRESNRKGLELGEIIEVLVS-----------KLSTLAQAGIHYQDEIT 249

Query: 79  CLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIM--VSFSVAAIN 136
                +   +E +++    ++ + G    I Q     +      +      + F  + I 
Sbjct: 250 ----HIGKTLEEMILDPRSLEKTKGRLIEITQKIDTHIQNLNKEVAEKKSEIEFLQSKIE 305

Query: 137 SLMKQVAL---RADFDFLTQVYSRSGLYEAL---KSPSLKQTQHLTVMLLDIDYFKSIND 190
            L +++      A  D LT V++R  L E+L   ++  L+     +V   DID+FK IND
Sbjct: 306 ELTQELCRAQEEASIDSLTGVHTRRFLEESLSRFEALFLRYESRYSVAFFDIDFFKKIND 365

Query: 191 NYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVE 250
            YGHE GD+VL+ F R +++ V  + + AR GGEEF V +P +N V+    AE+IR  VE
Sbjct: 366 KYGHEAGDRVLATFGRLLKQSVRQEDIAARYGGEEFIVILPEMNLVEAWRFAERIRALVE 425

Query: 251 LQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
              F +Q   + ++VS G+        +  +D   L+  AD  LY +K+ GRN+
Sbjct: 426 RSVFVYQDMRIKVSVSGGIAER-----SECEDRKALIKFADARLYEAKEGGRNQ 474


>UniRef50_B5JSY0 Response regulator PleD n=1 Tax=gamma proteobacterium HTCC5015
           RepID=B5JSY0_9GAMM
          Length = 261

 Score =  108 bits (270), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 60/170 (35%), Positives = 95/170 (55%), Gaps = 9/170 (5%)

Query: 138 LMKQVALRADFDFLTQVYSRSGLYEALKSPSLK---QTQHLTVMLLDIDYFKSINDNYGH 194
           + KQ+   A+ D LT +Y+R   ++       +    + H ++++LD+D+FKSIND +GH
Sbjct: 77  VQKQLEELANKDALTGLYNRQYFFDHANEWDKRCRENSGHFSLLMLDVDHFKSINDRFGH 136

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
             GD+VL   +  I+  +  + + AR GGEEF   +P  N      +AE+IR G+E Q F
Sbjct: 137 PVGDRVLQRVSNVIKGFMRQEDMCARYGGEEFICLLPDTNAAGAKAVAERIRLGMEHQAF 196

Query: 255 TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
             + + L L+VSIG     A+ ++  D+   L+  AD  LY +K  GRNR
Sbjct: 197 -LKARGLSLSVSIG-----ATTMSANDNLETLIERADQALYEAKDGGRNR 240


>UniRef50_A6VWF8 Diguanylate cyclase n=1 Tax=Marinomonas sp. MWYL1
           RepID=A6VWF8_MARMS
          Length = 368

 Score =  108 bits (269), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 88/312 (28%), Positives = 141/312 (45%), Gaps = 33/312 (10%)

Query: 10  FSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWC 69
           F   +L++     L            + +  +AL +     V  GG  S   PL    W 
Sbjct: 63  FLVSILLLITFYILKTSSYRHYHNCSRFIAIVALYILCFYLVCAGGVNSSG-PL----WI 117

Query: 70  AVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQM--------FSARLGIATM 121
            V   P +T    F+     I+  A  +  +S+   F   QM        F  RL    +
Sbjct: 118 YV--IPSIT--FAFLGLKQGIIANAAFIFIVSIMLFFPNDQMLLTTYSYEFKTRLIYVFL 173

Query: 122 AICPIMVSFSVAAINSLMK------QVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHL 175
            I  +   + VA   S M+      +   +A FD+LT + +R G+ + L     +Q +H 
Sbjct: 174 TIVTLSGLYEVARYRSFMRLKTMKDKYEYQAQFDYLTFLPNRRGIQKILNKDQ-RQRKHT 232

Query: 176 ----TVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVP 231
               T+ +LDID FK IND +GHE GD VL   +R ++  +  +  +AR GGEEF + +P
Sbjct: 233 HKVSTIAILDIDKFKVINDEFGHEVGDMVLKHTSRVLRDCIRSQDSLARWGGEEFLLLLP 292

Query: 232 SVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEAD 291
                + L++ E IR+ VE  PF     ++++T+S+G+            DFN+ +  +D
Sbjct: 293 ETTEQEALVLLESIRECVEETPFGHGNISIFITLSVGLCETSPDV-----DFNETIKFSD 347

Query: 292 TCLYRSKKDGRN 303
             LYR+K+ GRN
Sbjct: 348 VSLYRAKQAGRN 359


>UniRef50_Q47W79 GGDEF domain protein n=1 Tax=Colwellia psychrerythraea 34H
           RepID=Q47W79_COLP3
          Length = 334

 Score =  108 bits (269), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 56/169 (33%), Positives = 101/169 (59%), Gaps = 7/169 (4%)

Query: 139 MKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHE 195
           + ++A  +  D LTQVY+R    ++L+    K  +H   L++++LD+D+FK +NDNYGH+
Sbjct: 161 LAEIAQISRIDGLTQVYNRRHWQDSLEQEYAKARRHDKKLSLIMLDLDHFKLLNDNYGHQ 220

Query: 196 CGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFT 255
            GD VL   +  I  ++  +    R GGEEFA+ +P  +    + +A++I + +   PFT
Sbjct: 221 GGDMVLIEVSALISTLLRVEDTFGRYGGEEFAIILPETDSAGAIELAQRICRIIATTPFT 280

Query: 256 WQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           +  + + +TVS+GV    A   +   ++ +L+ +AD+ LY++K  GRN+
Sbjct: 281 YNDQVIKVTVSLGV----AQLSSKESNYEELITQADSALYQAKSQGRNQ 325


>UniRef50_Q1K1S4 Diguanylate cyclase n=4 Tax=Bacteria RepID=Q1K1S4_DESAC
          Length = 515

 Score =  108 bits (269), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 62/183 (33%), Positives = 102/183 (55%), Gaps = 8/183 (4%)

Query: 127 MVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDID 183
           M++  +   N L++++A   + D LT+ Y+       L    + S +    L+V+++DID
Sbjct: 327 MLTAELEKKNKLLERLA---NVDGLTEAYNHRYFQNFLDREINRSERNDYTLSVVMVDID 383

Query: 184 YFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAE 243
            FK  ND +GH+ GD +L  FA   + ++ +  L AR GGEEF + +P  N  +G ++AE
Sbjct: 384 NFKKFNDLHGHQVGDYILKQFADVARSLLREYDLFARYGGEEFVLVLPETNAQEGEVVAE 443

Query: 244 KIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           K R  +    FT +++T Y+T S GV     +   +  D N ++ +AD+ LY SKK GRN
Sbjct: 444 KFRSTLSEHTFTHERETYYITASFGVSDISPAKDKI--DKNDVISQADSALYESKKKGRN 501

Query: 304 RTS 306
           R +
Sbjct: 502 RVT 504


>UniRef50_C4WGI0 Diguanylate cyclase (GGDEF) domain-containing protein n=1
           Tax=Ochrobactrum intermedium LMG 3301 RepID=C4WGI0_9RHIZ
          Length = 392

 Score =  108 bits (269), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 72/220 (32%), Positives = 116/220 (52%), Gaps = 14/220 (6%)

Query: 91  VLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSV--AAINSLMKQVALRADF 148
           +L A S++    G  F+    +  +  + + AI  ++  F++  AA +  + +++   D 
Sbjct: 171 LLTARSLLGEVDGENFAATVFW--QWTVFSTAIAAVLTGFALLAAAGHDRIGELSHERDS 228

Query: 149 DFLTQVYSRSGL---YEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LT + +R GL   Y AL     K+     V + DIDYFK++ND+YGH  GD VL  FA
Sbjct: 229 DPLTGLLNRRGLEMRYNALSHT--KRGASGWVAVCDIDYFKALNDDYGHAAGDAVLQEFA 286

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
             ++K++G++ L+AR GGEEF + +  +   + L + E +R+ +E   F        +T 
Sbjct: 287 GILRKLLGERSLIARTGGEEFVICLHDMQADNVLELMEGVRRNIETHRFQRLSDETSVTC 346

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
           SIG        L    D  + + +AD  LY +KKDGRNRT
Sbjct: 347 SIGC-----VRLQEQGDLWQAVDKADKVLYAAKKDGRNRT 381


>UniRef50_B2V685 Diguanylate cyclase/phosphodiesterase n=3 Tax=Sulfurihydrogenibium
           RepID=B2V685_SULSY
          Length = 800

 Score =  108 bits (269), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 51/159 (32%), Positives = 99/159 (62%), Gaps = 5/159 (3%)

Query: 146 ADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           A++DFLT+V++R  + E ++  +++ ++   +++LD+D FK IND +GH+ GD++L    
Sbjct: 388 ANYDFLTRVFNRRKMMELIQ-KNIENSKKFAILMLDMDDFKRINDTFGHDLGDEILKEIV 446

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
           + ++ I   + ++ R GGEEF +  P  +  + L +AE IRK +  +P   +   +Y++V
Sbjct: 447 KILKNIRRQQDIIGRYGGEEFIILSPDADGKEALNIAEDIRKAISEKPVVVRDNKIYISV 506

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           SIG+    A +    +  ++L+  AD  LY++KK+G+N+
Sbjct: 507 SIGI----AEFPIHGNSPSELLKAADIALYKAKKEGKNK 541


>UniRef50_B9L727 Diguanylate cyclase/phosphodiesterase n=1 Tax=Nautilia profundicola
           AmH RepID=B9L727_NAUPA
          Length = 686

 Score =  108 bits (269), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 61/180 (33%), Positives = 103/180 (57%), Gaps = 17/180 (9%)

Query: 133 AAINSLMKQVALRADFDFLTQVYSRSGLYEALKS---PSLKQTQHLTVMLLDIDYFKSIN 189
             I S   ++ +RA+FD LT + +R    + LK     S++  +   V+ +DIDYFK IN
Sbjct: 242 KTIQSEKHKLFIRANFDALTGLCNRECFMQKLKDAYYDSIRNNKKFAVLFIDIDYFKQIN 301

Query: 190 DNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA-----EK 244
           D  GH+ GDKVL + A  ++K V    +V+R GG+EF V +  ++ ++ +++      E+
Sbjct: 302 DTDGHKVGDKVLKILAERLKKSVRKTDVVSRFGGDEFLVLLKDIHSIEDVIIYTQRILEE 361

Query: 245 IRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           I+K +E+       K  Y+T SIG+    + Y    +D +KL++ AD  +Y+SK DG++R
Sbjct: 362 IKKEIEINS-----KKYYVTGSIGI----SIYPDNGEDLDKLIIYADIAMYQSKNDGKDR 412


>UniRef50_Q1N3P2 Probable two-component response regulator n=1 Tax=Bermanella
           marisrubri RepID=Q1N3P2_9GAMM
          Length = 364

 Score =  108 bits (269), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 63/164 (38%), Positives = 92/164 (56%), Gaps = 15/164 (9%)

Query: 149 DFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LT +Y+R     AL      + +    L+++ LD+D+FK INDN+GH  GD+VL   A
Sbjct: 194 DTLTGIYNRQYFDNALDMQWDLASRSENSLSILFLDLDHFKKINDNFGHLAGDQVLCHAA 253

Query: 206 RHIQKIVGDK-GLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLT 264
               +I   K  ++AR GGEEFA+ +P+    D L +AE+IR  +E  P    Q  ++LT
Sbjct: 254 HLFSEIARRKTDMIARYGGEEFAIILPATEKQDALDLAEQIRHAIENTPCRSDQGLIHLT 313

Query: 265 VSIGVG----SGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           VSIGV     S + S +T  D       +AD  LY++K +GRN+
Sbjct: 314 VSIGVNSVVPSPQGSPVTFLD-------QADQALYQAKNNGRNQ 350


>UniRef50_Q1D632 GAF domain/GGDEF domain protein n=2 Tax=Cystobacterineae
           RepID=Q1D632_MYXXD
          Length = 710

 Score =  107 bits (268), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 60/175 (34%), Positives = 102/175 (58%), Gaps = 9/175 (5%)

Query: 138 LMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH----LTVMLLDIDYFKSINDNYG 193
           L +Q+   A  D LT +Y+    ++A     L Q++      +++L D+D+FKS+ND YG
Sbjct: 525 LYEQMERMATTDGLTGLYNHR-TFQAKADEVLAQSRRYQRKFSLILTDVDHFKSVNDTYG 583

Query: 194 HECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP 253
           H  GD+VL   AR I+ +  D  +VAR GGEEF + +P  +      ++E+IR+ V+ + 
Sbjct: 584 HPTGDQVLKGVARIIKTMARDTDIVARYGGEEFVIIMPETDAKGAFTISERIREAVKAEV 643

Query: 254 FTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
           F  +   L +T+S+G+    A++     +  +L+  AD CLY SK++GRN++ T+
Sbjct: 644 FQTEMGPLRITMSLGI----ATFPDSAMEKQQLIDLADQCLYHSKRNGRNQSVTV 694


>UniRef50_A4XQ87 Diguanylate cyclase n=1 Tax=Pseudomonas mendocina ymp
           RepID=A4XQ87_PSEMY
          Length = 375

 Score =  107 bits (268), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 62/168 (36%), Positives = 98/168 (58%), Gaps = 7/168 (4%)

Query: 141 QVALRADFDFLTQVYSR---SGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECG 197
           Q+ L +  D LTQ+ +R   + L+ +L + +L+Q + L+++LLDID+FK +ND +GH  G
Sbjct: 205 QLDLLSRTDSLTQLGNRYQFNNLFPSLVANALRQGEPLSLVLLDIDFFKKVNDEHGHAGG 264

Query: 198 DKVLSVFARHIQKIVGDKG-LVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTW 256
           D  LS FA  ++++    G  + R+GGEEF V +P         MAE+ R+ +E +    
Sbjct: 265 DACLSAFAERMRQVFRRDGDALLRLGGEEFGVLLPGTTLAQAREMAERFRQELESEGLQL 324

Query: 257 QQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
             + L LT S+GVGS      +  D F +     D+ LYR+K++GRNR
Sbjct: 325 ADQCLKLTTSLGVGSFDKRQDSDADAFFR---RVDSALYRAKREGRNR 369


>UniRef50_Q1DC46 FHA domain/GGDEF domain protein n=2 Tax=Myxococcales
           RepID=Q1DC46_MYXXD
          Length = 354

 Score =  107 bits (268), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 65/159 (40%), Positives = 93/159 (58%), Gaps = 7/159 (4%)

Query: 149 DFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LT + ++    E L+    + T++   LT+M+ DID+FK IND +GH  GD VL   A
Sbjct: 197 DGLTGINNKRYFLEYLEKEMGRSTRYQRTLTLMMFDIDHFKQINDVHGHLAGDYVLRELA 256

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
           + I+++V  +   AR GGEEFAV +P   P    L AEKIR+ +E + F +  K + +T+
Sbjct: 257 QSIKRLVRREQCFARYGGEEFAVVLPEDGPDKARLFAEKIRRLIEGKSFVYDDKEIPVTI 316

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           SIGV    +  L  T  F K+   AD  LY++KK GRNR
Sbjct: 317 SIGVAEQTSDMLEPT-HFIKV---ADANLYKAKKSGRNR 351


>UniRef50_C1DD63 Sensor protein n=1 Tax=Laribacter hongkongensis HLHK9
           RepID=C1DD63_LARHH
          Length = 379

 Score =  107 bits (268), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 59/176 (33%), Positives = 92/176 (52%), Gaps = 24/176 (13%)

Query: 140 KQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDK 199
            Q+ +RA +D LTQ+ +R  + E L       +Q L V+L DID+FK++ND +GH+ GD 
Sbjct: 212 NQLEVRATYDPLTQLLNRGAILEGLSQSCCDPSQPLAVILADIDHFKNVNDVHGHQAGDM 271

Query: 200 VLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQK 259
            L   AR + +++     V R GGEEF + +P   P   +++AE++R+ V  +P      
Sbjct: 272 ALEAVARRLGRVLRGGDAVGRYGGEEFLIVLPGATPDVAMIVAERLRQAVAGEP------ 325

Query: 260 TLYLTVSIGVGSGRASYLTLT-----------DDFNKLMVEADTCLYRSKKDGRNR 304
                  + +G GR+  LTL+            D   L+ EAD  LY +K  GRN+
Sbjct: 326 -------VDLGGGRSQSLTLSLGVCCQPGGQAHDVACLIAEADQALYAAKAGGRNQ 374


>UniRef50_Q315M6 Diguanylate cyclase n=1 Tax=Desulfovibrio desulfuricans subsp.
           desulfuricans str. G20 RepID=Q315M6_DESDG
          Length = 403

 Score =  107 bits (268), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 61/177 (34%), Positives = 97/177 (54%), Gaps = 11/177 (6%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKS 187
           ++ A+   M+Q A     D LT + +R G+Y+ L     + T+     +V+L D+D+FK+
Sbjct: 219 TLVALTREMEQCACT---DPLTGLLNRRGIYDRLNEERARATRSGSTFSVILCDVDHFKN 275

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           +ND +GH+CGD VL   A H ++ V  + +V R GGEEF   +P  +    L +AEK+R 
Sbjct: 276 VNDCFGHQCGDHVLHQLAEHFRRSVRGQDVVCRWGGEEFLFILPETDEQGALNLAEKLRS 335

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
            VE  P  +    + +T+S+GV        TLT+     +  AD  LY +K+ GRN+
Sbjct: 336 TVEQTPVNYHGMPIDITLSLGVQE-----CTLTESTEFHIRVADQKLYIAKEHGRNK 387


>UniRef50_C9YC42 Putative uncharacterized protein n=1 Tax=Curvibacter putative
           symbiont of Hydra magnipapillata RepID=C9YC42_9BURK
          Length = 409

 Score =  107 bits (268), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 61/160 (38%), Positives = 90/160 (56%), Gaps = 8/160 (5%)

Query: 149 DFLTQVYSRSGLYEALKSPSLKQTQH----LTVMLLDIDYFKSINDNYGHECGDKVLSVF 204
           D LT +++R+   E L +  LK+ +      T++LLD+D+FK IND +GH  GD VL   
Sbjct: 252 DGLTGLFNRNTFVE-LSTNELKRAKRQGSATTILLLDLDHFKRINDTWGHPAGDVVLRHV 310

Query: 205 ARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLT 264
           A+ +   V    LV R+GGEEF V +P         +AEKIR+ +E+    W+ K + +T
Sbjct: 311 AQTMVNSVRSTDLVGRLGGEEFIVLLPHTTAEASRKIAEKIRQRLEVSDIRWEGKRIAVT 370

Query: 265 VSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
            SIG+    A     + +F+ L  EAD  LY +K+ GRNR
Sbjct: 371 ASIGLSGTTAEE---SREFDSLYTEADKALYLAKQRGRNR 407


>UniRef50_Q89SS4 Bll2326 protein n=1 Tax=Bradyrhizobium japonicum RepID=Q89SS4_BRAJA
          Length = 435

 Score =  107 bits (268), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 61/173 (35%), Positives = 98/173 (56%), Gaps = 7/173 (4%)

Query: 134 AINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQ--TQHLTVMLLDIDYFKSINDN 191
           A+++  +++A +A  D+LT + +R   +EA     L       L ++LLD+D FK++ND+
Sbjct: 245 ALHAEKERLAWQASHDWLTGLANRRA-FEARLQGELDNIAAGSLGLILLDLDQFKNVNDS 303

Query: 192 YGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVEL 251
            GH  GD++L   +R +Q+      LVAR+GG+EF + +P  +P D   +AE++R+ +EL
Sbjct: 304 CGHLAGDRLLCQVSRLLQQDRRPHDLVARLGGDEFGLILPRCSPFDATDIAERLRRALEL 363

Query: 252 QPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
             F W  +   +T SIG+        TL D     M  AD   YR+K+ GRNR
Sbjct: 364 FSFAWDDRCFAVTASIGITCITDRDTTLED----AMRRADAACYRAKEKGRNR 412


>UniRef50_Q1LIC9 Diguanylate cyclase (GGDEF domain) n=1 Tax=Cupriavidus
           metallidurans CH34 RepID=Q1LIC9_RALME
          Length = 599

 Score =  107 bits (268), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 79/257 (30%), Positives = 130/257 (50%), Gaps = 12/257 (4%)

Query: 55  GAGSLAFPL-PALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFS 113
           GA ++AF L   +IW    +  Q+  L  F      I+ +AN  + + V SP +      
Sbjct: 338 GAFAIAFALLGTMIWLHSLFRRQI--LKPFFAATRSILAIANGNLSVRVPSPNNYRGEIR 395

Query: 114 ARL-GIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY----EALKSPS 168
           A L  + T+    +           L+ Q+   A+ D LTQ+ +R  L     +   SP+
Sbjct: 396 ALLEAVHTLKRYSLDKQQLEQDRQRLIAQLTTMAETDALTQLLNRRALEARACDLCASPA 455

Query: 169 LKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAV 228
             +  ++ +++ DID+FK IND YGH  GD+ L +     ++++G   L AR GGEEFAV
Sbjct: 456 ADKP-YVALVMFDIDHFKRINDTYGHIAGDRALEIVGAVCREVLGTGDLAARFGGEEFAV 514

Query: 229 AVPSVNPVDGLLMAEKIRKGV-ELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLM 287
                 P + L +AE++++ + E++      +   +TVS+GV  GR     +  D + L+
Sbjct: 515 VSLVSTPGEALRLAEQLKEKLREIRVTLESARPFGMTVSLGVAIGRRE--DVGQDLSALI 572

Query: 288 VEADTCLYRSKKDGRNR 304
            +AD  LYR+K+ GRNR
Sbjct: 573 RQADLMLYRAKRGGRNR 589


>UniRef50_Q02P32 Putative two-component response regulator n=6 Tax=Pseudomonas
           aeruginosa RepID=Q02P32_PSEAB
          Length = 525

 Score =  107 bits (268), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 70/192 (36%), Positives = 115/192 (59%), Gaps = 13/192 (6%)

Query: 119 ATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSR-SGLYEA-LKSPSLKQTQHLT 176
           AT+  C     + ++   ++ +++ L A  D LT +++R S L++A L   + ++ +H  
Sbjct: 339 ATLIWC-----YDISRRKAMEQELRLLASTDTLTGLHNRHSFLHQAELMLKAAERFRHPC 393

Query: 177 V-MLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNP 235
           V ++LDID+FK+IND++GH  GD+ L   A  +++ + +  L+ R+GGEEFA  +P V+ 
Sbjct: 394 VALMLDIDHFKNINDSHGHLTGDRALQRVAETLRQGLREVDLLGRLGGEEFAALLPEVSL 453

Query: 236 VDGLLMAEKIRKGVE-LQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCL 294
              L +AE++R GVE L+      + L +TVSIGV   R +     DD   L+V AD+ L
Sbjct: 454 DQALDVAERLRAGVEALRVSNPDGEPLRMTVSIGVALRRDA----GDDLESLLVRADSAL 509

Query: 295 YRSKKDGRNRTS 306
           Y++K  GRNRT 
Sbjct: 510 YQAKSGGRNRTE 521


>UniRef50_A9DAY4 Periplasmic sensor diguanylate cyclase n=1 Tax=Hoeflea
           phototrophica DFL-43 RepID=A9DAY4_9RHIZ
          Length = 442

 Score =  107 bits (268), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 57/142 (40%), Positives = 82/142 (57%), Gaps = 11/142 (7%)

Query: 173 QHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPS 232
           +  T++ +DID+FK +ND +GH  GD+VL   AR +   + D   V R+GGEEFAV +P 
Sbjct: 298 EQFTLLAIDIDHFKQVNDTHGHAAGDEVLRAVARTMMDTMRDGDRVFRVGGEEFAVLLPR 357

Query: 233 VNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDF---NKLMVE 289
            +     L AE+IR+ VE+ P + +   + +TVSIG+ S        T DF   + L+  
Sbjct: 358 TDGAPARLAAERIRQAVEMAPVSLKATEIAVTVSIGMAS--------TLDFPEKSDLLEA 409

Query: 290 ADTCLYRSKKDGRNRTSTMRYG 311
           AD  LYR+K +GRNR    R G
Sbjct: 410 ADAALYRAKHEGRNRIIVNRPG 431


>UniRef50_B1Z9Z6 Diguanylate cyclase n=6 Tax=Alphaproteobacteria RepID=B1Z9Z6_METPB
          Length = 363

 Score =  107 bits (268), Expect = 5e-22,   Method: Compositional matrix adjust.
 Identities = 70/198 (35%), Positives = 102/198 (51%), Gaps = 15/198 (7%)

Query: 113 SARLGIATM----AICPIMVSFSVAAINSLMKQVALR--ADFDFLTQVYSRSGLYEALKS 166
           SARL I  +     I  I+++ S+ A+ +     ALR  A  D LT   +R GL  A   
Sbjct: 171 SARLAIVGIFVVDQISSIVLTTSILALEAERAHAALRRMARTDALTGALNREGLAAAAGG 230

Query: 167 PSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEF 226
                     V++ D+D+FKSIND +GH  GD VL  F R    ++ +  L+AR+GGEEF
Sbjct: 231 ----DPGPAGVIVADLDHFKSINDRFGHAGGDAVLREFTRRSAGLLPEGALLARLGGEEF 286

Query: 227 AVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKL 286
            + +P   P     +AE++R  V   P  W+   + +TVS+GV   RA   +L +  ++ 
Sbjct: 287 GIVLPGHAPNATAYLAERLRHAVGATPVPWRDAAIPVTVSVGVAR-RADGESLHEAIDR- 344

Query: 287 MVEADTCLYRSKKDGRNR 304
              AD  LY +K  GRNR
Sbjct: 345 ---ADRALYVAKTAGRNR 359


>UniRef50_B2JUD5 Diguanylate cyclase n=4 Tax=Burkholderia RepID=B2JUD5_BURP8
          Length = 241

 Score =  107 bits (268), Expect = 5e-22,   Method: Compositional matrix adjust.
 Identities = 60/170 (35%), Positives = 96/170 (56%), Gaps = 8/170 (4%)

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGH 194
           + +L +Q+A RA  D LT V++RS + E  ++  + +     +++LDID FK +ND++GH
Sbjct: 74  MQALAQQLAHRATHDALTGVFNRSAVIE--RTTKVLRHDSAVMIILDIDEFKRVNDDFGH 131

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
             GD V+      +++IVG++G + R+GGEEF V +P+  P + L  AEK+R+ +    F
Sbjct: 132 PAGDAVIMGIVECLRRIVGERGFIGRVGGEEFTVLLPAHEPAEALRQAEKMREAIGRHVF 191

Query: 255 TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
                   +T S GV +          DF+     AD  LYR+K+ GRNR
Sbjct: 192 ASPVDR-RVTASFGVSANPPGT-----DFDTAYGFADAALYRAKRGGRNR 235


>UniRef50_Q1K433 Ammonium transporter n=1 Tax=Desulfuromonas acetoxidans DSM 684
           RepID=Q1K433_DESAC
          Length = 606

 Score =  107 bits (267), Expect = 5e-22,   Method: Compositional matrix adjust.
 Identities = 69/175 (39%), Positives = 99/175 (56%), Gaps = 17/175 (9%)

Query: 132 VAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQT--QHLTVMLLDIDYFKSIN 189
           VA+  SL  QV     FD LT+VY+R G  E ++    +QT    ++V+++DID+FK+IN
Sbjct: 443 VASNKSLQSQVY----FDPLTKVYNRRGALEKIR----RQTPATPMSVIIIDIDHFKTIN 494

Query: 190 DNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGV 249
           D YGH+ GD VL   A  IQ+++ ++ L AR GGEEF +   +    +   +AEK+R  +
Sbjct: 495 DTYGHDVGDVVLKELAELIQQLIRNQDLFARWGGEEFILLCETSILDEARRIAEKLRSSI 554

Query: 250 ELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
              PFT      +LT S GV S           F+ L  +AD  LYR+K+ GRNR
Sbjct: 555 AAYPFT---TVNHLTCSFGVCSPERP----DQPFDALFKDADEALYRAKELGRNR 602


>UniRef50_Q1MZ89 Response regulator containing a CheY-like receiver domain and a
           GGDEF domain n=2 Tax=Gammaproteobacteria
           RepID=Q1MZ89_9GAMM
          Length = 577

 Score =  107 bits (267), Expect = 6e-22,   Method: Compositional matrix adjust.
 Identities = 62/170 (36%), Positives = 98/170 (57%), Gaps = 10/170 (5%)

Query: 139 MKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ----HLTVMLLDIDYFKSINDNYGH 194
           + Q  L+A  D LT + +R G Y+       ++ +     L++++ D+D FKSIND YGH
Sbjct: 391 LNQSQLKAMTDSLTGLPNR-GAYDVYAQQEYERYKRYGGELSLIVCDVDKFKSINDTYGH 449

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
           + GDKVL + +R ++K   +  L+AR GGEEF V +P     D + +AEKI + V   PF
Sbjct: 450 QAGDKVLQLISRQVKKGTRETDLLARYGGEEFVVLLPETKQEDAVSVAEKIIEAVATSPF 509

Query: 255 TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
            ++ K + +T+S GV S +  Y        ++   AD  LYR+K++GRN+
Sbjct: 510 HFRGKRVQITISCGVASFKKGYRP-----EQVFDAADAALYRAKENGRNQ 554


>UniRef50_Q5LPK8 GGDEF domain protein n=1 Tax=Ruegeria pomeroyi RepID=Q5LPK8_SILPO
          Length = 249

 Score =  107 bits (267), Expect = 6e-22,   Method: Compositional matrix adjust.
 Identities = 61/175 (34%), Positives = 95/175 (54%), Gaps = 8/175 (4%)

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGH 194
           I+ L +Q+A     D +TQ+Y+R+ L E L+    +  +   +++ DID+FK IND YGH
Sbjct: 65  IDKLNQQLAHLNRIDQMTQLYNRACLLEKLEQ---EPEEAGMILIADIDHFKQINDTYGH 121

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
           + GD V+   AR +Q+    +G+ AR GGEEF + VP ++       AE IR+ VE Q  
Sbjct: 122 DVGDLVIIEVARVLQRSSLPEGIAARFGGEEFVIYVPRLDLEAAEFRAEAIRQAVEAQSV 181

Query: 255 TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
               + L  T+SIG+         + ++   ++  AD  LYR+K  GRN+    R
Sbjct: 182 MIDGRKLSCTISIGI-----EIRQMQENVGDVLKRADEALYRAKAQGRNQVVAAR 231


>UniRef50_Q12S41 GGDEF domain n=1 Tax=Shewanella denitrificans OS217
           RepID=Q12S41_SHEDO
          Length = 337

 Score =  107 bits (267), Expect = 6e-22,   Method: Compositional matrix adjust.
 Identities = 65/159 (40%), Positives = 92/159 (57%), Gaps = 6/159 (3%)

Query: 146 ADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           A  D LTQ Y+R  L +  +S S   T  + ++LLD+DYFK IND YGHE GD VL   A
Sbjct: 176 ALLDPLTQHYNRLALSKRFQSLSQTSTLPMCILLLDLDYFKVINDTYGHEAGDIVLKACA 235

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
           + I  I G      R+GGEEF V V + +    + +AE IRK +    F ++ + L +TV
Sbjct: 236 KQISSIAGYSD-TFRVGGEEFCVLVQAEHANQAVELAESIRKLISDTEFLFENQNLAVTV 294

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           S+GV +  A  +TL++    L+ +AD  LY +K  GRN+
Sbjct: 295 SVGVATFEAK-MTLSN----LLAKADKQLYLAKDLGRNK 328


>UniRef50_Q085X7 Diguanylate cyclase n=2 Tax=Alteromonadales RepID=Q085X7_SHEFN
          Length = 357

 Score =  107 bits (267), Expect = 6e-22,   Method: Compositional matrix adjust.
 Identities = 77/229 (33%), Positives = 120/229 (52%), Gaps = 30/229 (13%)

Query: 96  SVIDISVGSPFSIPQM------FSARLGIA--TMAICPIMVSFS-VAAINSLMK------ 140
           S+I I + SP  +PQ       F  RL ++  T      +  +S + + NS +K      
Sbjct: 128 SIIAIIMFSPIEMPQYATYSTEFKVRLILSFLTTTFLSALYEYSRMLSYNSALKLGKKYQ 187

Query: 141 QVALRADFDFLTQVYSRSG---LYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECG 197
           Q+AL    D LT + +R     + +  KS   +  + L+V+L D+D+FK +ND YGH CG
Sbjct: 188 QLALS---DPLTTLANRRNALTILQQEKSRISRNNEPLSVLLCDLDHFKMVNDKYGHNCG 244

Query: 198 DKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ 257
           D VL+  ++  ++ V  +  VAR GGEEF   +P  +     ++AEKIR  V      + 
Sbjct: 245 DMVLTELSQVFKQSVRQQDCVARWGGEEFLFILPQTSAEQASVIAEKIRTNVHHHKVHFL 304

Query: 258 QKTLYLTVSIGVGSGRASYLTLTDDFN--KLMVEADTCLYRSKKDGRNR 304
           +  + LT+SIG+         LTDD N  +L+  AD  LY++KK+GRN+
Sbjct: 305 KHEISLTISIGISQ-------LTDDQNIDELINNADRNLYQAKKNGRNQ 346


>UniRef50_A4BD76 GGDEF domain protein n=1 Tax=Reinekea blandensis MED297
           RepID=A4BD76_9GAMM
          Length = 476

 Score =  107 bits (267), Expect = 6e-22,   Method: Compositional matrix adjust.
 Identities = 56/160 (35%), Positives = 91/160 (56%), Gaps = 8/160 (5%)

Query: 148 FDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVF 204
            D LT + +R G    L +    + +  Q L++ ++DID+FK IND +GH  GDKVL + 
Sbjct: 316 LDPLTGLPNRQGFDRRLSAELARAERYDQALSIAIIDIDFFKRINDEFGHLVGDKVLKMM 375

Query: 205 ARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLT 264
           A+ ++++  +   ++R GGEEF + +P     +GL   +K+R+ VE +PF +Q   + LT
Sbjct: 376 AKEMKRVCRESDFLSRFGGEEFVLLLPQTTLEEGLTAVDKLRRHVETRPFHYQNTPVNLT 435

Query: 265 VSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           VS GV   +     + +     +  AD  LY SK++GRNR
Sbjct: 436 VSAGVAQRQ-----VNETLESWLDRADAALYVSKREGRNR 470


>UniRef50_A6W1T4 Diguanylate cyclase n=1 Tax=Marinomonas sp. MWYL1
           RepID=A6W1T4_MARMS
          Length = 368

 Score =  107 bits (267), Expect = 6e-22,   Method: Compositional matrix adjust.
 Identities = 61/183 (33%), Positives = 102/183 (55%), Gaps = 12/183 (6%)

Query: 127 MVSFSVAAINSLMKQVA----LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDI 182
           +  +S++  N  +K+ +    L A  D LT++ +R G+ + L++ S     +  ++L D+
Sbjct: 191 IYEYSMSRFNQELKETSAKLKLVAYIDALTELLNRRGMLQRLETSSY---HNFHLLLADV 247

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           D+FK IND YGH+ GD  LS  A+ IQ  + + GL +R GGEEF +AV   +  +   +A
Sbjct: 248 DFFKRINDGYGHDAGDYALSQLAKIIQMSIPEGGLASRWGGEEFLIAVCDCSESEAFALA 307

Query: 243 EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           E IRK VE   F +  +   +T+S G+ +     +  +    + +  AD+ LY +K+ GR
Sbjct: 308 ESIRKDVEDYEFEYLDQKFRMTLSFGMAT-----MNESTSLREAITIADSRLYGAKRAGR 362

Query: 303 NRT 305
           NRT
Sbjct: 363 NRT 365


>UniRef50_A1SVZ1 Diguanylate cyclase n=1 Tax=Psychromonas ingrahamii 37
           RepID=A1SVZ1_PSYIN
          Length = 477

 Score =  107 bits (266), Expect = 6e-22,   Method: Compositional matrix adjust.
 Identities = 59/183 (32%), Positives = 98/183 (53%), Gaps = 9/183 (4%)

Query: 126 IMVSFSV-AAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSL---KQTQHLTVMLLD 181
           I+++F +   +N   K++   A +D LT + +R    E L+   L   ++  HL++   D
Sbjct: 296 ILIAFLILKTVNKYYKEMEHLAKYDALTNLKNRRAFNEELEHSLLLCKRRASHLSLTFFD 355

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           +D FKS+ND +GH+ GDKVL   A  ++  +    ++ R GGEEF VA       D   +
Sbjct: 356 LDDFKSVNDTFGHQTGDKVLQYVADILKDDIRQTDIIGRWGGEEFIVAFIDTELEDAKFI 415

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
            EKIR  +E   F  Q K + +T S G+ +     +T  D  + L+  AD  LY++K++G
Sbjct: 416 TEKIRAHIEKDSFLSQLKNMKVTASFGLTT-----ITTQDTLDSLLERADQALYKAKENG 470

Query: 302 RNR 304
           +N+
Sbjct: 471 KNQ 473


>UniRef50_A3DHG2 Diguanylate cyclase with GAF sensor n=3 Tax=Clostridium
           thermocellum RepID=A3DHG2_CLOTH
          Length = 415

 Score =  107 bits (266), Expect = 6e-22,   Method: Compositional matrix adjust.
 Identities = 69/193 (35%), Positives = 103/193 (53%), Gaps = 7/193 (3%)

Query: 126 IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQT----QHLTVMLLD 181
           I V+  V +    + Q+   A  D LT++Y+R  L + L +  L+ T    Q L+V+++D
Sbjct: 226 IEVAKPVISSKRTLHQLRKNATTDKLTKLYNRRFLEQYLDN-QLEITGFSNQKLSVIMMD 284

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           ID FK IND YGH  GD VL  FAR I + +    LVAR GGEEF   +PS +  +   +
Sbjct: 285 IDNFKRINDTYGHNAGDAVLVTFARVILRCLRQTDLVARYGGEEFIAILPSSDTKNAYDI 344

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
           AE+IR+ +  +P           +S   G   ++Y T   + N L+  AD  LY++K+ G
Sbjct: 345 AERIRESIAAEPMPKINDVQLPNISCSFGV--STYPTHAKNKNDLIKAADIALYKAKQAG 402

Query: 302 RNRTSTMRYGEEV 314
           +NR  T   G E+
Sbjct: 403 KNRVITYSEGMEM 415


>UniRef50_D0LHJ8 Diguanylate cyclase n=1 Tax=Haliangium ochraceum DSM 14365
           RepID=D0LHJ8_HALO1
          Length = 303

 Score =  107 bits (266), Expect = 7e-22,   Method: Compositional matrix adjust.
 Identities = 59/163 (36%), Positives = 92/163 (56%), Gaps = 7/163 (4%)

Query: 149 DFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LT V+++    E L+    +  +H   LT+++ DID+FK IND +GH  GD VL   +
Sbjct: 137 DGLTGVHNKRYFVEFLEREIARCARHQRPLTLLMFDIDHFKQINDTHGHLTGDYVLKEMS 196

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
           R +++ +  + L+AR GGEEFA  +P  + V G+   E+IR+ V  +PF ++     +T+
Sbjct: 197 RRLRERIRKEELLARYGGEEFAAVLPETDHVGGMTFGEQIRQLVGGEPFEYEGDRFQVTI 256

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
           S+GV +     L    D    +  AD  LYR+K+ GRNR   M
Sbjct: 257 SVGVHTLYGQSL----DVKGFIKHADDNLYRAKRSGRNRVIGM 295


>UniRef50_Q2S9K6 Response regulator containing a CheY-like receiver domain and a
           GGDEF domain n=1 Tax=Hahella chejuensis KCTC 2396
           RepID=Q2S9K6_HAHCH
          Length = 418

 Score =  107 bits (266), Expect = 7e-22,   Method: Compositional matrix adjust.
 Identities = 66/165 (40%), Positives = 88/165 (53%), Gaps = 10/165 (6%)

Query: 146 ADFDFLTQVYSRSGLYEALKS---PSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLS 202
           A+ D+LT +Y+R  L+ A K     + +  + LT  ++D+D+FK IND YGHE GD+ + 
Sbjct: 257 ANRDYLTGMYNRRYLFSAAKELYRVAKENGEPLTAAMIDVDHFKRINDTYGHEAGDRAIC 316

Query: 203 VFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY 262
            FA+ I +  GD  L AR GGEEF V  P V+      M E  R  VE     +    L 
Sbjct: 317 AFAKMIGETFGDY-LAARFGGEEFCVLFPGVSIEKISPMLESFRHKVEQTAIPFLSDHLR 375

Query: 263 LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
           LTVSIG          L D  + L+  AD  LY SK +GRNR +T
Sbjct: 376 LTVSIGATD------VLGDSLDNLIRRADVLLYESKDNGRNRLTT 414


>UniRef50_A9AYQ2 Diguanylate cyclase and serine/threonine protein kinase with TPR
           repeats n=1 Tax=Herpetosiphon aurantiacus ATCC 23779
           RepID=A9AYQ2_HERA2
          Length = 600

 Score =  107 bits (266), Expect = 7e-22,   Method: Compositional matrix adjust.
 Identities = 62/183 (33%), Positives = 104/183 (56%), Gaps = 8/183 (4%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK-SPSLKQT--QHLTVMLLDIDYFKS 187
            +A I  +  Q+A  A  D LT++ +R GLYE +  +   +QT  Q    ++ DID+FK+
Sbjct: 414 QLADIQQINLQLAEWAKTDSLTEILNRRGLYEQIDLALQHQQTDAQGWAWIMFDIDFFKA 473

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           IND+YGH+ GD+VL   A+  + ++    +  R GGEEF V +P  +  + +++AE++R 
Sbjct: 474 INDSYGHDSGDEVLRGIAQRARLVLRHSDVFGRYGGEEFLVFLPHTSMQEAIVIAERLRT 533

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
            +   P+  +Q  + +T+S+G+     ++    DD  +L   AD  LYRSK  GRN  + 
Sbjct: 534 AIANTPYVVKQTAVNVTISLGI-----AWTEQVDDPERLTQLADQALYRSKAAGRNCYTI 588

Query: 308 MRY 310
            R+
Sbjct: 589 ERF 591


>UniRef50_A6WV43 Diguanylate cyclase n=1 Tax=Ochrobactrum anthropi ATCC 49188
           RepID=A6WV43_OCHA4
          Length = 382

 Score =  107 bits (266), Expect = 7e-22,   Method: Compositional matrix adjust.
 Identities = 72/220 (32%), Positives = 118/220 (53%), Gaps = 14/220 (6%)

Query: 91  VLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSV--AAINSLMKQVALRADF 148
           +L A S++    G  F+    +  +  + + AI  ++  F++  AA    + +++   D 
Sbjct: 161 LLTARSLLGDVDGDDFATTVFW--QWTVFSTAIAAVVTGFALLAAAGYDRIGELSHERDS 218

Query: 149 DFLTQVYSRSGLYEALKSPSLKQTQHLT---VMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LT + +R GL   ++  +L QT+      V + DIDYFK++ND YGH  GD VL  FA
Sbjct: 219 DPLTGLLNRRGL--EMRYDALSQTKKGVPGWVAVCDIDYFKALNDAYGHAAGDAVLKEFA 276

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
             ++K++G++ L+AR GGEEF + V  ++  +   + E +R+ +E   F    K   +T 
Sbjct: 277 GILRKLIGERPLIARTGGEEFVICVDDMHADNVFQLMEGVRQNIERHRFQRLAKEASVTC 336

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
           SIG        L    DF + + +AD  LY +KK+GRNRT
Sbjct: 337 SIG-----CVRLPEQGDFWQAVDKADKILYAAKKEGRNRT 371


>UniRef50_A1SY47 Diguanylate cyclase n=1 Tax=Psychromonas ingrahamii 37
           RepID=A1SY47_PSYIN
          Length = 794

 Score =  106 bits (265), Expect = 9e-22,   Method: Compositional matrix adjust.
 Identities = 64/172 (37%), Positives = 99/172 (57%), Gaps = 15/172 (8%)

Query: 138 LMKQVALRADFDFLTQVYSRSGLYEALKSPSL----KQTQH-LTVMLLDIDYFKSINDNY 192
           L++ VA +   D LT +++R  L+E   SP L    ++TQ  L+++L+D+D+FK IND Y
Sbjct: 629 LLQDVAFK---DNLTSIFNRHYLFEI--SPMLLTVSEETQTPLSLLLIDVDHFKKINDTY 683

Query: 193 GHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQ 252
           GH  GD +L    ++IQ I+    +  R GGEEF + +P  N  + +++AEK+R  VE  
Sbjct: 684 GHLTGDNILKFIVKNIQAILRADDIFVRFGGEEFIILLPKANLEESVMVAEKLRLSVEQN 743

Query: 253 PFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
            +      + +TVSIG     AS    T+   KL+  AD  LY +K+ GRN+
Sbjct: 744 NYHKNGMDISITVSIG-----ASQYQHTETLEKLISRADLALYSAKEKGRNQ 790


>UniRef50_A3J836 Putative diguanylate cyclase (GGDEF domain) n=1 Tax=Marinobacter
           sp. ELB17 RepID=A3J836_9ALTE
          Length = 588

 Score =  106 bits (265), Expect = 9e-22,   Method: Compositional matrix adjust.
 Identities = 61/167 (36%), Positives = 94/167 (56%), Gaps = 7/167 (4%)

Query: 146 ADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLS 202
           A  D LT + +R G     E+L S   ++ +++ V ++DID FK+IND YGH  GDKVL 
Sbjct: 413 AQTDLLTGLSNRRGFLPVAESLWSLVTRKNRNVCVAMIDIDRFKNINDQYGHAVGDKVLK 472

Query: 203 VFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY 262
           V A  + +      L+AR GGEEF + +P  +  + L +AE+ R  +E      + + + 
Sbjct: 473 VIADELYRSRRRGDLLARWGGEEFTLLLPETSEAEALKVAERFRHNIEQLVTNDRGRVIQ 532

Query: 263 LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
            T+SIGV S  + ++TL    ++ +  AD  LYR+K  GRN+ S  R
Sbjct: 533 CTISIGVTSRHSEHVTL----DQAIARADEELYRAKLQGRNQVSFGR 575


>UniRef50_A3Y5H4 Diguanylate cyclase (GGDEF domain) n=1 Tax=Marinomonas sp. MED121
           RepID=A3Y5H4_9GAMM
          Length = 419

 Score =  106 bits (265), Expect = 9e-22,   Method: Compositional matrix adjust.
 Identities = 60/169 (35%), Positives = 94/169 (55%), Gaps = 16/169 (9%)

Query: 149 DFLTQVYSRSGLYEALKSPSLKQ----TQHLTVMLLDIDYFKSINDNYGHECGDKVLSVF 204
           D LT +Y+R   +EA     LKQ       L+++L D+D+FK +ND YGH+ GD VL++ 
Sbjct: 235 DKLTNIYNRRS-FEARLLQDLKQYDKFQTELSIILFDVDHFKFVNDTYGHQAGDSVLTLL 293

Query: 205 ARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLT 264
           A   Q+ V    +VAR GGEEF + +P+       ++AEK+R  +E   F  Q   + +T
Sbjct: 294 AEIAQQTVRSNDIVARYGGEEFIILLPNTGKNGSQVIAEKLRSAIENAAFDTQSYKIQIT 353

Query: 265 VSIGVGSGRASYLTLTD----DFNKLMVEADTCLYRSKKDGRNRTSTMR 309
           +S+GV         ++D    + + L+  AD  LY +K +GRN+ S M+
Sbjct: 354 ISLGVA-------CISDVQHPNLDNLIKSADDALYYAKHNGRNQVSYMQ 395


>UniRef50_A6X7T2 Diguanylate cyclase n=1 Tax=Ochrobactrum anthropi ATCC 49188
           RepID=A6X7T2_OCHA4
          Length = 231

 Score =  106 bits (265), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 72/208 (34%), Positives = 112/208 (53%), Gaps = 19/208 (9%)

Query: 108 IPQMF----SARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYE- 162
           + QM+    S R GIA M++ P++V+   AA    +  ++  A FD LT + SRS   E 
Sbjct: 21  LSQMYEFQPSLRFGIALMSLGPLLVATINAARQKELSDLSRAAYFDVLTGLLSRSAFRER 80

Query: 163 --ALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVAR 220
              L   S+   + LT M+LDID+FK IND  GH  GDKVL  FA+ ++  + +  L  R
Sbjct: 81  GQKLLRESIVAGRDLTAMMLDIDHFKQINDQNGHASGDKVLIDFAQLVRDQLREGDLFGR 140

Query: 221 MGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTW-QQKTLYLTVSIGVGSGRASYLTL 279
           +GGEEFA+ +P+ +      +A ++R  V+   FT    + L +TVS+G+       + +
Sbjct: 141 LGGEEFAILLPNTSSRQAEKIASRVRLRVQNATFTGTDNQPLKVTVSMGL-------VDI 193

Query: 280 TD----DFNKLMVEADTCLYRSKKDGRN 303
            D      ++L+  AD  +Y +K  GRN
Sbjct: 194 ADCPSTKLDELLHCADQSMYAAKSSGRN 221


>UniRef50_Q2SNU2 Response regulator containing a CheY-like receiver domain and a
           GGDEF domain n=1 Tax=Hahella chejuensis KCTC 2396
           RepID=Q2SNU2_HAHCH
          Length = 367

 Score =  106 bits (265), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 56/158 (35%), Positives = 88/158 (55%), Gaps = 8/158 (5%)

Query: 149 DFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LTQ+ +R  + + L+    +  +H    +V+LLDID+FK IND YGH+ GD VL   +
Sbjct: 199 DELTQLPNRRDMQQQLEKEYFRYKRHGSHFSVILLDIDHFKMINDTYGHDAGDFVLMKIS 258

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
             +        + AR GGEEF + +P  + V  L +AE++RK +E  P  ++ + +  T+
Sbjct: 259 ELLVNACRKMDMAARWGGEEFLIQLPDTSLVQALTLAERLRKSIEASPLQYKNQEIRYTI 318

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           S GV S     ++   D   L+ +AD  LY++K  GRN
Sbjct: 319 SCGVCS-----ISQAKDLASLLKQADVNLYQAKIKGRN 351


>UniRef50_Q2IXE2 Response regulator receiver modulated diguanylate cyclase n=6
           Tax=Alphaproteobacteria RepID=Q2IXE2_RHOP2
          Length = 457

 Score =  106 bits (265), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 59/161 (36%), Positives = 95/161 (59%), Gaps = 9/161 (5%)

Query: 149 DFLTQVYSRSGLYEALKSPSLK---QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LT +++R  +   L + + +   + + L +M+LDID+FK+IND YGH+ GD VL  FA
Sbjct: 295 DGLTGLHNRRYMESHLATLAEQAGSRGKPLALMILDIDFFKAINDTYGHDAGDDVLREFA 354

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQ--KTLYL 263
             I+K +    L  R GGEEF + +P  +     ++AE++R+ +  +PF  ++  K + +
Sbjct: 355 VRIKKSIRGIDLACRYGGEEFVIVMPETDLQVAQMVAERLRRAIAGEPFAIEKGTKRIAV 414

Query: 264 TVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           T+SIG+ +       + D    L+  ADT LYR+K DGRNR
Sbjct: 415 TISIGLSTLERKGEAVRD----LLKRADTALYRAKHDGRNR 451


>UniRef50_Q07MN8 Diguanylate cyclase n=10 Tax=Bradyrhizobiaceae RepID=Q07MN8_RHOP5
          Length = 418

 Score =  106 bits (264), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 94/299 (31%), Positives = 139/299 (46%), Gaps = 49/299 (16%)

Query: 13  GVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVR 72
           G++ +  +LT A  G   R   ++  PAI      I  ++ GG   L   L  L+    +
Sbjct: 123 GIVAIYAVLTAAELGSERRKSMQRRWPAI------IVPLLHGGVLMLPILLSDLLTPPAQ 176

Query: 73  YTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSV 132
            T     L+ F   AVE+VL A       VG+ F+I  + S R                 
Sbjct: 177 TTAGNVWLMVF---AVELVLYA-------VGTVFAIFMLVSERT---------------- 210

Query: 133 AAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQT---QHLTVMLLDIDYFKSIN 189
                 ++     A  D LT +++R G  EA      ++    + +TVM+ DIDYFKSIN
Sbjct: 211 ------VRAHKTAASIDPLTGLFNRRGFTEATTRMIEREAAAGRPVTVMIFDIDYFKSIN 264

Query: 190 DNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVP-SVNPVDGLLMAEKIRKG 248
           D +GH  GD++L +FA  I   +    L  R+GGEEFA  +P S++  + L+ AE++R  
Sbjct: 265 DRFGHPAGDELLKLFATLITSSLRITDLSGRIGGEEFAALLPCSID--EALVAAERVRWS 322

Query: 249 VELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
            E          +  TVSIGV  G A       + + L+  ADT LY++K+ GRNR  T
Sbjct: 323 FETCGIVVDNDPVATTVSIGVAGGPAR-----TELDVLLAAADTALYQAKRGGRNRVET 376


>UniRef50_A8FU11 Diguanylate cyclase n=9 Tax=Shewanella RepID=A8FU11_SHESH
          Length = 420

 Score =  106 bits (264), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 64/175 (36%), Positives = 97/175 (55%), Gaps = 15/175 (8%)

Query: 137 SLMKQVALRADFDFLTQVYSRS---GLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYG 193
            +++++  +A+ D+LT VY+R      YE L     ++   LT+ LLDID FK +ND YG
Sbjct: 244 DMIRKLWDQANLDYLTGVYNRRYFFSQYEELIILKKQKRGALTLALLDIDLFKGVNDTYG 303

Query: 194 HECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP 253
           H+ GD+VL  FA  +++  G    V+R GGEEF VA   +N V    + +K R  +E +P
Sbjct: 304 HDVGDEVLVEFAARLKRSFGQHFTVSRFGGEEFIVAFRGLNEVKSFALMDKFRSQLESKP 363

Query: 254 FTWQQKTLYLTVSIGVGSGRASYLTLTDD-----FNKLMVEADTCLYRSKKDGRN 303
            +  +  L +TVS G+ S       L+DD      + L+  AD  LY +K+ GRN
Sbjct: 364 ISTSRGELSVTVSAGIAS-------LSDDESEESLDTLIQRADKALYDAKEAGRN 411


>UniRef50_A6TMF8 Diguanylate cyclase n=1 Tax=Alkaliphilus metalliredigens QYMF
           RepID=A6TMF8_ALKMQ
          Length = 512

 Score =  106 bits (264), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 65/218 (29%), Positives = 114/218 (52%), Gaps = 24/218 (11%)

Query: 90  IVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFD 149
           ++ + N+  +I  G      Q+ +  LG+    I               +  + +RA +D
Sbjct: 309 VLYLDNAAYEIFSGEQIRFLQIIARHLGLVISKI-------------DYIANLRIRAKYD 355

Query: 150 FLTQVYSR---SGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFAR 206
            LT +++R     +YEA  +    +     ++++DID FK +ND YGH  GD+VL   AR
Sbjct: 356 GLTGLFNRHTFDTIYEAFYNGIKHEKMDFAILMVDIDNFKEVNDQYGHPVGDEVLRKMAR 415

Query: 207 HIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVS 266
            +Q+ + D  ++AR GGEE  + +   NP +   +AE+IRK +E    + + + + +TVS
Sbjct: 416 AMQQSLRDHDVIARYGGEEMIIILKGSNPPEAKGIAERIRKSIE----SLEIQGIRITVS 471

Query: 267 IGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           IG+ + R  Y +   D  +L+  AD CLY +K+ G+N+
Sbjct: 472 IGMANFR--YDSYEKD--ELITIADKCLYEAKRKGKNQ 505


>UniRef50_A1VA66 Diguanylate cyclase with PAS/PAC sensor n=3 Tax=Desulfovibrio
           vulgaris RepID=A1VA66_DESVV
          Length = 827

 Score =  106 bits (264), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 60/161 (37%), Positives = 95/161 (59%), Gaps = 7/161 (4%)

Query: 149 DFLTQVYSRSGLY-EALK--SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LT V +R   + +A +  + +L+    L V++LDID+FK++ND YGH+ GD+VL  FA
Sbjct: 651 DPLTGVRNRRQFFVDANREFARALRHDSGLAVLMLDIDHFKNVNDLYGHQAGDEVLRAFA 710

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
               + +    +  R+GGEEFA  +P+ +P + +  AE++RK VE +   ++   L  TV
Sbjct: 711 ACCVEALRAYDVFGRLGGEEFAALLPAASPEEAMETAERLRKRVERRSVVYEGTALQCTV 770

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
           S+GV S  A+ L     F+ ++  AD  LY +K  GRNR+ 
Sbjct: 771 SVGVTSLAAADLG----FDDMLRRADRALYAAKDHGRNRSE 807


>UniRef50_Q2BLA2 Putative uncharacterized protein n=1 Tax=Neptuniibacter
           caesariensis RepID=Q2BLA2_9GAMM
          Length = 811

 Score =  106 bits (264), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 57/172 (33%), Positives = 101/172 (58%), Gaps = 5/172 (2%)

Query: 146 ADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLS 202
           A  D LT + +R      L++    + +  + L++ +LD+D+FK IND+ GH  GD VL 
Sbjct: 641 ATTDELTSLANRRKFLTTLEAELARAKRYHRELSLCMLDLDHFKRINDDNGHSAGDSVLV 700

Query: 203 VFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY 262
             A+ ++ ++ +  +  R+GGEEFA+ +P  +  D L++AE++R+ +E     +Q  TL 
Sbjct: 701 EVAKIMEAMLRESDMAGRIGGEEFAILLPDTSEDDALILAERLREAIESLEIKYQAHTLK 760

Query: 263 LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEV 314
           LT SIGV S   + +      ++L+  AD C+Y +K++GRN  S +R  +++
Sbjct: 761 LTTSIGVAS--LNQMPEIVQASELLSAADDCMYYAKQNGRNLVSNVRTTQQL 810


>UniRef50_B0TH60 Ggdef domain protein, putative n=1 Tax=Heliobacterium modesticaldum
           Ice1 RepID=B0TH60_HELMI
          Length = 414

 Score =  106 bits (264), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 65/164 (39%), Positives = 95/164 (57%), Gaps = 9/164 (5%)

Query: 143 ALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLS 202
           A +A  D LT +Y+     + L+   L + + +T++L DID+FK  ND YGH CGD++L 
Sbjct: 244 ARQAVTDGLTGLYNHRYFQQCLQE--LMKERPVTLLLFDIDHFKGFNDTYGHPCGDEILR 301

Query: 203 VFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY 262
             A  ++  +G + + AR GGEEFAV +P  +   G+  AE+IR+ V    F    +TL 
Sbjct: 302 QIAHILRSQLGPQEVAARYGGEEFAVILPDADLRRGIERAEQIRQAVANFCFRNPDRTLC 361

Query: 263 L--TVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           L  TVSIGV    A +     D ++L+  AD  LYR+K+ GRNR
Sbjct: 362 LNITVSIGVSEKLAGW-----DKSRLIEAADRALYRAKEQGRNR 400


>UniRef50_C8Q7A8 Diguanylate cyclase n=1 Tax=Pantoea sp. At-9b RepID=C8Q7A8_9ENTR
          Length = 389

 Score =  106 bits (264), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 94/300 (31%), Positives = 143/300 (47%), Gaps = 39/300 (13%)

Query: 21  LTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCA-----VRYTP 75
           L  AI  + P F     MP   L+V ++  +  G        L  L+W A     V + P
Sbjct: 100 LLWAILCIFPAFYFS--MPKRVLVVCLLCIIYTGA-------LIQLLWRARASLTVTFWP 150

Query: 76  -QVTCLLTFVTGAVEIVL---VANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFS 131
            Q+   +  +     I L   VA  V     GS FS+  +  + L +       I ++F+
Sbjct: 151 AQMLLWIHLLFHVARIFLDDAVATPVHGAIGGSSFSVYVILESILFV-------IGLTFT 203

Query: 132 VAAINSLMKQVA--LRADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVMLLDIDYFK 186
           + A+ +   Q+A  L +  D LT V++R  L+   E + +  L+Q    T +L D+D+FK
Sbjct: 204 ILAMVNERTQIAHKLASLHDPLTSVWNRRALFAQAEKIIARRLRQQLPFTAVLFDLDHFK 263

Query: 187 SINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIR 246
           SIND YGH+ GD+VL  F +  Q ++ ++G  AR+GGEEFA  +P  +     ++ E+IR
Sbjct: 264 SINDRYGHQQGDRVLIDFCQIAQSLLPEEGQFARLGGEEFAAILPG-DSEQAQMVCERIR 322

Query: 247 KGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
              +L         +  TVSIG  +     L     F  L+  AD  LYR+K  GRNRT 
Sbjct: 323 VATQLS----LPDNISYTVSIGYATSSQEDL----HFPTLLALADEALYRAKASGRNRTE 374


>UniRef50_A8UUF5 Diguanylate cyclase (GGDEF domain) n=1 Tax=Hydrogenivirga sp.
           128-5-R1-1 RepID=A8UUF5_9AQUI
          Length = 283

 Score =  106 bits (264), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 64/177 (36%), Positives = 97/177 (54%), Gaps = 12/177 (6%)

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDN 191
           I+ L++++   AD D LT  Y+R  + E L     +  ++   L+V+ +D+D FK +ND 
Sbjct: 116 ISDLIRELRFLADTDSLTGFYNRRKIEEILAKEIERSRRYGNPLSVLFIDVDNFKELNDT 175

Query: 192 YGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVEL 251
           YGH+ GD+VL   A  I+  +     V R GGEEF V +P  +    L +AE+IRK VE 
Sbjct: 176 YGHKSGDEVLRKIAEIIKSELRRTDYVGRFGGEEFMVILPETDSQSALRVAERIRKRVER 235

Query: 252 QPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
           + F    KT  +TVS+GV     + L   DD N L    D  +Y +K+ G+NR+  +
Sbjct: 236 EDF----KTGKVTVSVGV-----TELKEGDDLNTLFNRVDRAMYLAKERGKNRSELL 283


>UniRef50_P54595 Uncharacterized protein yhcK n=2 Tax=Bacillus subtilis group
           RepID=YHCK_BACSU
          Length = 359

 Score =  106 bits (264), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 63/171 (36%), Positives = 89/171 (52%), Gaps = 7/171 (4%)

Query: 138 LMKQVALRADFDFLTQVYSRSGLYEALKS--PSLKQTQHLTVML--LDIDYFKSINDNYG 193
           L KQ   +A FDFLT VY+R    E  K+       T H    L  +DID+FK+IND YG
Sbjct: 184 LFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAADTPHFQFALIYMDIDHFKTINDQYG 243

Query: 194 HECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP 253
           H  GD+VL      +++ + +    AR+GGEEFAV +P+ +      +AE+IR  V   P
Sbjct: 244 HHEGDQVLKELGLRLKQTIRNTDPAARIGGEEFAVLLPNCSLDKAARIAERIRSTVSDAP 303

Query: 254 FTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
                      +S+ +  G A Y   T+    L + AD  LY++K+ GRNR
Sbjct: 304 IVLTNGD---ELSVTISLGAAHYPNNTEQPGSLPILADQMLYKAKETGRNR 351


>UniRef50_A8FZ07 Diguanylate cyclase n=2 Tax=Shewanella RepID=A8FZ07_SHESH
          Length = 298

 Score =  106 bits (264), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 84/280 (30%), Positives = 140/280 (50%), Gaps = 12/280 (4%)

Query: 44  IVSVIAS-VVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISV 102
           I+ V+ S +VI GA  LA  + A +W  VR  P      ++    + I++     +  + 
Sbjct: 4   ILPVLGSGLVISGALLLAMAI-APVWKIVRQLPTGGLRYSWGFLILLILIFIAGYVIYAK 62

Query: 103 GSPFSIPQMFSARLGIATMA---ICPIMVSFSVAAINSLMKQVALRAD--FDFLTQVYSR 157
            SP    Q+F   + I          ++ S S+     +M+  AL+ +   D L  +++R
Sbjct: 63  FSPVQFSQLFDLVVPIIFFGGAIFVFVVCSLSLRTTRDIMQNYALKQENITDSLMGIFNR 122

Query: 158 SGLYEALKSPS---LKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGD 214
             L   LK  +   L  +Q L++ L+DID+FK +NDNYGH+ GD VL   A+ I+  + +
Sbjct: 123 RYLDRRLKDETERALNYSQPLSIFLIDIDHFKQVNDNYGHQVGDLVLKNIAQLIKHSLRE 182

Query: 215 KGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY--LTVSIGVGSG 272
             ++AR GGEEF V +P         +AE++R  VE    T  +++    L++S+ V  G
Sbjct: 183 SDVLARFGGEEFVVILPRTKDSTSYTLAERLRHVVEDFQLTLPEESDKDSLSISVTVSIG 242

Query: 273 RASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGE 312
            A       D   L+  AD  LY++K++GRN+  T + G+
Sbjct: 243 VAGLNAQCKDCQCLIENADRALYQAKRNGRNQVITSKSGK 282


>UniRef50_Q3A271 Sensor histidine kinase/FOG: GGDEF domain protein n=1
           Tax=Pelobacter carbinolicus DSM 2380 RepID=Q3A271_PELCD
          Length = 422

 Score =  105 bits (263), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 51/161 (31%), Positives = 89/161 (55%), Gaps = 7/161 (4%)

Query: 146 ADFDFLTQVYSRSGLYEA---LKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLS 202
           A  D LT + +R   +E    L++   +   H ++++LDID+FK IND YGHE GD+ L 
Sbjct: 257 ARLDPLTGLSNRRAFFEYGLLLENQIARHHHHFSIIMLDIDHFKKINDCYGHEMGDEALK 316

Query: 203 VFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY 262
             A H+  IV    ++ R+GGEEFA+ +P  +  +  +M+E+++  +     +  ++ + 
Sbjct: 317 TLAEHLNAIVRSSDILGRLGGEEFAIIMPHASSEEAAIMSERLKTAISKIVLSDNEQRIR 376

Query: 263 LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
            TVS G+        +    F +++  AD  LY++K +GRN
Sbjct: 377 FTVSFGIAECNEKITS----FQQVLNNADKALYQAKNEGRN 413


>UniRef50_A6CY69 Putative GGDEF family protein n=1 Tax=Vibrio shilonii AK1
           RepID=A6CY69_9VIBR
          Length = 244

 Score =  105 bits (263), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 57/175 (32%), Positives = 95/175 (54%), Gaps = 6/175 (3%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSIND 190
           +++  + L  ++  +++ D LTQ+ +R   +  L + +   T H  ++L+DIDYFK +ND
Sbjct: 72  NISKRHRLELKLRKQSESDPLTQIANRRYFFSTLATITKSTTPHC-LLLMDIDYFKKVND 130

Query: 191 NYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVE 250
            YGH  GD  L      IQ I+      AR+GGEEFA+ +P +       +AE+IR  + 
Sbjct: 131 TYGHLAGDNTLKEVVARIQDIIRPDDTFARVGGEEFALLLPDIEEHTAYEIAERIRCTIA 190

Query: 251 LQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
             PF ++Q+T  +T+S+G+   R       +  N +   AD  LY +K  GRN++
Sbjct: 191 DTPFHYEQQTFSITLSVGITQAR-----YQERNNHIFSRADDALYIAKSRGRNQS 240


>UniRef50_C6BW86 Diguanylate cyclase n=1 Tax=Desulfovibrio salexigens DSM 2638
           RepID=C6BW86_DESAD
          Length = 555

 Score =  105 bits (263), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 51/137 (37%), Positives = 79/137 (57%)

Query: 168 SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFA 227
           +++  Q  ++M++DID+FK IND YGH  GD VL   ++  Q++V    ++AR GGEEF 
Sbjct: 401 AIRAGQPCSLMIMDIDHFKVINDTYGHTVGDIVLQQISKAFQEVVRSSDIIARYGGEEFV 460

Query: 228 VAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLM 287
           V  P  +   G  +AE++R+ VE + F   ++ L  T+SIGV           D +  ++
Sbjct: 461 VVAPGSDIDSGRTLAERLRQSVEARIFNNDEQPLTCTISIGVSHYATDIKFGVDAYEDML 520

Query: 288 VEADTCLYRSKKDGRNR 304
             AD  LY++K  GRNR
Sbjct: 521 ARADNALYKAKDTGRNR 537


>UniRef50_UPI000185121C diguanylate cyclase n=1 Tax=Bacillus coahuilensis m4-4
           RepID=UPI000185121C
          Length = 466

 Score =  105 bits (263), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 61/178 (34%), Positives = 95/178 (53%), Gaps = 9/178 (5%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKS---PSLKQTQHLTVMLLDIDYFKS 187
            +  + +L  Q+   A +D LT +Y+R   ++  +     S +Q    T++L+DIDYFK 
Sbjct: 282 DMTEVKNLQSQLEHFAYYDELTGIYNRRAFFQYCEEAFQESKEQDTPFTIILMDIDYFKK 341

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           +ND YGH  GD+VL   A+  Q  +    L AR GGEEF + V      +G  +AE++R 
Sbjct: 342 VNDTYGHSVGDQVLEQVAKVCQSQLHGHELFARYGGEEFVLGVKGYTEEEGAALAEQLRS 401

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDD-FNKLMVEADTCLYRSKKDGRNR 304
            VE          + +T+S+GV +     LT  D+   +++  AD  LYR+K+ GRNR
Sbjct: 402 EVEALTIHTPDGKITVTLSLGVAA-----LTKEDEALYQILNHADQALYRAKEAGRNR 454


>UniRef50_Q2JA03 Diguanylate cyclase (GGDEF domain) n=1 Tax=Frankia sp. CcI3
           RepID=Q2JA03_FRASC
          Length = 587

 Score =  105 bits (263), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 61/174 (35%), Positives = 94/174 (54%), Gaps = 10/174 (5%)

Query: 138 LMKQVALRADFDFLTQVYSRSGLYE---ALKSPSLKQTQHLTVMLLDIDYFKSINDNYGH 194
           L ++    AD D LT + +R   +E   AL    L   + L   ++DID+FK +ND +GH
Sbjct: 417 LFEETQRLADSDPLTGLANRRHFFEQADALVRGHLHAARSLAAFMIDIDHFKQVNDGHGH 476

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
             GD VL+  AR +Q  +G + +V R+GGEEFA  +       G+L AE++R+ +   P 
Sbjct: 477 AVGDAVLAEVARRVQGTLGPQDIVGRIGGEEFAAVLGCPAATAGVL-AERLRQAIGASPV 535

Query: 255 TWQQKTLYLTVSIGVGSGRASYLTLTDD-FNKLMVEADTCLYRSKKDGRNRTST 307
                 L +TVS+GV     + L   D     L++ AD  LY++K+ GR+R +T
Sbjct: 536 ATADGPLPVTVSVGV-----AMLNPDDSGLGDLLIRADVALYQAKRSGRDRVAT 584


>UniRef50_Q9RRJ2 GGDEF family protein n=1 Tax=Deinococcus radiodurans
           RepID=Q9RRJ2_DEIRA
          Length = 356

 Score =  105 bits (263), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 62/161 (38%), Positives = 86/161 (53%), Gaps = 12/161 (7%)

Query: 146 ADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLS 202
           A  D LT V  R+ L   L+     + +    L+V+L DID+FK +ND +GH  GD VL 
Sbjct: 202 ARLDALTGVAGRAALESELQRALDTARRTNSPLSVILADIDHFKQVNDVHGHGAGDDVLR 261

Query: 203 VFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY 262
            FA+ +++ VG  G+V R GGEEF   +P V   D L +AE++R+ V       +   L 
Sbjct: 262 AFAKRLRRNVGGAGMVGRWGGEEFMAVLPGVARDDALALAERLRQAVS----DTEIAGLP 317

Query: 263 LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           +T S GV + R       DD N+L   AD  LY +K  GRN
Sbjct: 318 VTASFGVAALRPD-----DDLNQLFSRADERLYDAKNGGRN 353


>UniRef50_A1RG31 Diguanylate cyclase n=3 Tax=Shewanella RepID=A1RG31_SHESW
          Length = 362

 Score =  105 bits (263), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 62/200 (31%), Positives = 114/200 (57%), Gaps = 12/200 (6%)

Query: 110 QMFSARLGIATMAICPIMVSFSVAAINSLMKQV-ALR--ADFDFLTQVYSR---SGLYEA 163
           +M S    I  +  C ++   S A    +M  + ALR  A+ D LT + +R   + L + 
Sbjct: 161 EMISLFRHINVLGACALLAGVSYAYSQIVMSAITALRNVANTDELTGLINRRSLTALIDR 220

Query: 164 LKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGG 223
             + +L+    ++++L DIDYFK IND+YGH  GD VL   A  +Q ++ +  +VAR GG
Sbjct: 221 EAARTLRTHASMSLVLCDIDYFKRINDSYGHAAGDHVLVNVANLLQGVLREYDVVARWGG 280

Query: 224 EEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDF 283
           EEF + +P+ + ++ + +AE++R+ V     +++++T+ +T+++GV       +   +++
Sbjct: 281 EEFLLLLPNTDIIEAMKVAERLREIVACSHLSFEEQTIPVTMTLGVA------VLGDENW 334

Query: 284 NKLMVEADTCLYRSKKDGRN 303
           +  +  AD  LYR K+ GRN
Sbjct: 335 HSTLARADEALYRGKRQGRN 354


>UniRef50_Q7CXW5 GGDEF family protein n=1 Tax=Agrobacterium tumefaciens str. C58
           RepID=Q7CXW5_AGRT5
          Length = 269

 Score =  105 bits (263), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 78/243 (32%), Positives = 120/243 (49%), Gaps = 25/243 (10%)

Query: 71  VRYTPQVTCLLTFV-----TGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICP 125
           + ++ ++ CL+T +     TG + ++     V D+  G       M S  LG A      
Sbjct: 29  LEFSVRIACLVTLIVIVMCTGGLTLLAQFGLVTDLFNGI------MLSVTLGGAVAFTVT 82

Query: 126 IMVSFSVAAINSLMKQVALR----ADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLD 181
           ++V +  A    ++ Q   R    +  D LT + +R GLY A             V  LD
Sbjct: 83  LLVCWLNAREVQILVQSHERFLHLSHTDALTGLSNRLGLYAACAELG----SDYCVAFLD 138

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           ID+FK++ND Y H  GD V++  AR I++       VAR+GGEEF V V   +P+  L M
Sbjct: 139 IDHFKAVNDGYSHLVGDLVIASVARRIKEHFDPPAHVARLGGEEF-VVVQETSPLAFLQM 197

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
            E++R  +E  P  +Q   + +T+SIGV     ++    + F+K+M  AD  LYR+K  G
Sbjct: 198 CERVRAAIETTPVAYQDLRITVTISIGV-----AFRGDAEIFDKVMHNADLALYRAKGGG 252

Query: 302 RNR 304
           RNR
Sbjct: 253 RNR 255


>UniRef50_B5ZEJ8 Diguanylate cyclase n=2 Tax=Gluconacetobacter diazotrophicus PAl 5
           RepID=B5ZEJ8_GLUDA
          Length = 390

 Score =  105 bits (263), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 63/164 (38%), Positives = 95/164 (57%), Gaps = 12/164 (7%)

Query: 146 ADFDFLTQVYSRSGLYEALKSPSLKQT--QHLTVMLLDIDYFKSINDNYGHECGDKVLSV 203
           A  DFLT + +R   Y+A +     QT  Q +++++ DID+FKSIND +GH  GD VL +
Sbjct: 221 AQTDFLTNIGNRHFFYQAGQKCLSGQTVGQPVSLLIFDIDHFKSINDIHGHAMGDAVLKL 280

Query: 204 FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK---GVELQPFTWQQKT 260
           FAR + + VG + ++ R+GGEEFA+ +P  +        + I +    +  Q F   +  
Sbjct: 281 FARAMGEEVGQEAIMGRLGGEEFAMLLPGSDRATARAAGQNIARRFTALAAQDF---RPP 337

Query: 261 LYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           L++TVSIG+   R S +TL D    L+  AD  LY++K  GRNR
Sbjct: 338 LHVTVSIGLTEVRTSRITLDD----LLAAADGALYQAKTLGRNR 377


>UniRef50_B9ZP75 Diguanylate cyclase n=3 Tax=Thioalkalivibrio sp. K90mix
           RepID=B9ZP75_9GAMM
          Length = 380

 Score =  105 bits (262), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 61/174 (35%), Positives = 92/174 (52%), Gaps = 6/174 (3%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSIND 190
           S +A  +  +Q+   A +D LT++ +R G  EA+     ++   + + +LD+D+FKS+ND
Sbjct: 174 SYSATLNTHEQLRTDARYDALTKLLNRRGFEEAMAGLPPERFP-VVLAILDLDHFKSVND 232

Query: 191 NYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVE 250
            +GHE GD  L  FARH++  V    L+ R GGEEF + +    P + L + + IR G  
Sbjct: 233 EHGHEAGDHALRAFARHLRPCVRGGDLLCRWGGEEFLLLITEAGPDEALAVVDDIRIGFA 292

Query: 251 LQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
                  +  L LT S G+     S L     F + +VEAD  LYR+K  GRN 
Sbjct: 293 RTVLPVGENGLKLTFSAGL-----SCLQNAGGFEQALVEADESLYRAKDRGRNH 341


>UniRef50_A8FBD0 ABC superfamily ATP binding cassette transporter, binding protein
           n=2 Tax=Bacillus pumilus RepID=A8FBD0_BACP2
          Length = 361

 Score =  105 bits (262), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 63/175 (36%), Positives = 95/175 (54%), Gaps = 9/175 (5%)

Query: 137 SLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQ-TQHLTVMLLDIDYFKSINDNY 192
            L+     +A +DFLT V ++    E L    S   K  T  ++++ LDIDYFKSIND Y
Sbjct: 183 QLLNLYKFQAHYDFLTGVLNKRKFDEVLNDAFSMKFKHPTHQMSLIYLDIDYFKSINDQY 242

Query: 193 GHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQ 252
           GH  GD VL    + + K       + R+GGEEFAV +P+        +AE++R+ +  Q
Sbjct: 243 GHHEGDMVLKEIGKRLIKNTRSSDYIGRIGGEEFAVFLPNCTVEKTWQIAERLRRKIADQ 302

Query: 253 PFTWQQ-KTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
           P   Q   ++++TVS+G     A Y   + D  +L + AD  LY++K+ GRN+ S
Sbjct: 303 PVYLQNGMSIHITVSLGC----AYYSGTSPDIKQLPIIADQELYKAKQSGRNQVS 353


>UniRef50_C1DCL4 Diguanylate cyclase n=1 Tax=Laribacter hongkongensis HLHK9
           RepID=C1DCL4_LARHH
          Length = 347

 Score =  105 bits (262), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 60/173 (34%), Positives = 101/173 (58%), Gaps = 14/173 (8%)

Query: 136 NSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH----LTVMLLDIDYFKSINDN 191
           N+ ++Q+A+   +D LT VYSR G++  L S +L  T+     L+ ++LDID+FK +ND 
Sbjct: 171 NAQLRQMAM---YDSLTGVYSR-GVFFELASEALALTRQECAPLSALMLDIDFFKKVNDT 226

Query: 192 YGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVEL 251
           +GH  GD+VL +  R +++ +    ++ R GGEEFAV +P         +A+++   +  
Sbjct: 227 WGHAAGDQVLRLAGRRLREQLRGSDIIGRCGGEEFAVILPRQQADRACAVAQQLCDAMCT 286

Query: 252 QPFTWQQKTLYLTVSIGVGSGRASYLTLTDD-FNKLMVEADTCLYRSKKDGRN 303
           +PF W+ + +  ++SIGV       L+  D+   KL+  AD  L ++K DGRN
Sbjct: 287 RPFPWEGQQIACSISIGVAE-----LSREDESIEKLLHRADLALLQAKGDGRN 334


>UniRef50_Q15V65 Diguanylate cyclase n=1 Tax=Pseudoalteromonas atlantica T6c
           RepID=Q15V65_PSEA6
          Length = 370

 Score =  105 bits (262), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 61/201 (30%), Positives = 105/201 (52%), Gaps = 14/201 (6%)

Query: 112 FSARLGIATMAICPIMVSF------SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK 165
           FS+RL  + + +  + V +      S   +  L ++   +A  D L+ + +R G+ E L+
Sbjct: 169 FSSRLIYSFITVSLLFVFYEYSRQRSFKTLQELSREFEKQARLDPLSGLQNRRGMLEKLE 228

Query: 166 ---SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMG 222
                +L+  ++LT+M+ DID+FK +ND +GH+ GD V++   +   K +  +  VAR G
Sbjct: 229 YEHQRTLRHHKNLTLMMCDIDHFKRVNDKFGHDVGDGVITQVGQLFDKALRKQDTVARWG 288

Query: 223 GEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDD 282
           GEEF   +P         +AEK+R  V  Q +     +  +TVS+G+       +   D+
Sbjct: 289 GEEFLFLLPETTQEQAFTLAEKLRAQVSKQQYQAGSDSFTVTVSLGIYQ-----MHPQDN 343

Query: 283 FNKLMVEADTCLYRSKKDGRN 303
            +  +  ADT LYR+K +GRN
Sbjct: 344 LDHAISRADTNLYRAKSNGRN 364


>UniRef50_B0UJW4 Diguanylate cyclase n=1 Tax=Methylobacterium sp. 4-46
           RepID=B0UJW4_METS4
          Length = 386

 Score =  105 bits (262), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 61/167 (36%), Positives = 90/167 (53%), Gaps = 14/167 (8%)

Query: 141 QVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKV 200
           ++A  A  D LT + +R GL +        + +   ++L DID+FK+IND +GHE GD V
Sbjct: 212 RLAHLAGTDPLTGLANRRGLSQLAHG----RARPAAILLADIDHFKAINDGHGHEGGDAV 267

Query: 201 LSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKT 260
           L  FAR ++  +  + + AR GGEEF V +   +P     +AE++R   E  PF   Q  
Sbjct: 268 LVEFARRLRGSLRARDIAARWGGEEFLVVLHGADPAMAEALAERVRAATEAHPFRVGQDP 327

Query: 261 LYLTVSIGVGSGRASYLTLTDDFNKL---MVEADTCLYRSKKDGRNR 304
           + +TVSIGV         L +D + +   +  AD  LY +K DGRNR
Sbjct: 328 IRVTVSIGVA-------ILREDEHGIEPALQRADAALYAAKSDGRNR 367


>UniRef50_A4TZG0 GGDEF n=1 Tax=Magnetospirillum gryphiswaldense RepID=A4TZG0_9PROT
          Length = 392

 Score =  105 bits (262), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 64/165 (38%), Positives = 93/165 (56%), Gaps = 13/165 (7%)

Query: 146 ADFDFLTQVYSRSGLYEALKSPSLKQTQH-----LTVMLLDIDYFKSINDNYGHECGDKV 200
           A  D LT+V +R   +   K+  L Q+        +V++LD+D FK+IND +GH  GD+V
Sbjct: 227 ASVDPLTEVLNRRSFFA--KAQGLWQSHQSDGRPFSVLMLDLDRFKAINDRHGHPTGDRV 284

Query: 201 LSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVE-LQPFTWQQK 259
           +  FAR ++  +    L+ RMGGEEFA+ +P V     L +AE+IR   E ++  +    
Sbjct: 285 IVAFARLLRDAMRHDDLLGRMGGEEFAIILPGVATAQALEVAERIRAASEAVEVLSDDGF 344

Query: 260 TLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
            + LTVSIG+  G  +  T  DD   LM  AD  LY++K  GRNR
Sbjct: 345 RVRLTVSIGLALGDGA--TSLDD---LMKRADAALYQAKDQGRNR 384


>UniRef50_Q6AL41 Putative uncharacterized protein n=1 Tax=Desulfotalea psychrophila
           RepID=Q6AL41_DESPS
          Length = 516

 Score =  105 bits (262), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 57/170 (33%), Positives = 94/170 (55%), Gaps = 8/170 (4%)

Query: 140 KQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKSINDNYGHEC 196
           +Q+   A+ D LT  Y+      AL    S S + +  +++++ DID FK  ND+YGH+ 
Sbjct: 337 RQLETLANIDGLTNCYNHRYFQNALDQELSRSSRNSLAISLIMFDIDNFKRFNDSYGHQA 396

Query: 197 GDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTW 256
           GD +L    R IQ+ +    ++AR GGEEF + +P     D L++AEK+R   E   F  
Sbjct: 397 GDFILCELTRLIQEQIRKDDVLARYGGEEFVIILPETEKEDALIVAEKVRHACEEHSFQN 456

Query: 257 QQKTLYLTVSIGVGSGRASYLTLTDDFNK--LMVEADTCLYRSKKDGRNR 304
             KT  +T+S+GV +  ++ ++     NK   + + D  LY +K++GRN+
Sbjct: 457 IHKTHQITISLGVATEHSAQIS---PLNKTSFIDKTDLALYSAKENGRNK 503


>UniRef50_Q0KEL5 Putative uncharacterized protein h16_A0406 n=2 Tax=Cupriavidus
           RepID=Q0KEL5_RALEH
          Length = 390

 Score =  105 bits (262), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 61/159 (38%), Positives = 88/159 (55%), Gaps = 8/159 (5%)

Query: 147 DFDFLTQVYSRSGLYEALKSPSLK--QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVF 204
           D D LTQ+++R  L EAL +  +   Q + L+V+L D+D+FK INDNYGH  GD VL+  
Sbjct: 224 DTDPLTQLHTRRSL-EALAAREIPPPQGKPLSVLLCDLDFFKFINDNYGHSAGDAVLAQI 282

Query: 205 ARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLT 264
            R I   +  + + AR+GGEEF V +P   P   L +AE++R+ +E            +T
Sbjct: 283 GRIIAAGIRRRDIAARLGGEEFVVLLPDTPPDAALHLAERLRQTLESTEMDVLPGMHTVT 342

Query: 265 VSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
            S GV + R       +D   L++ AD  LY +K  GRN
Sbjct: 343 ASFGVATLRPG-----EDLEALLMRADNVLYAAKNKGRN 376


>UniRef50_A0YPS9 Putative uncharacterized protein n=1 Tax=Lyngbya sp. PCC 8106
           RepID=A0YPS9_9CYAN
          Length = 965

 Score =  105 bits (262), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 63/161 (39%), Positives = 89/161 (55%), Gaps = 5/161 (3%)

Query: 147 DFDFLTQVYSRS---GLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV 203
           +FD LTQVYSR    GL E +     ++   L  M+ DID+FK IND YGH+ GD  L  
Sbjct: 801 EFDSLTQVYSRQYLLGLAERMFMRIKQEQTSLLCMMFDIDHFKLINDQYGHKAGDIALIA 860

Query: 204 FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL 263
           F+  + K +    +  R+GGEEF   VP ++   G  +AE+IR  VE  P T     + +
Sbjct: 861 FSEIVSKNLRSNDIFGRLGGEEFLAVVPEISLEAGKKLAERIRLEVEKTPITVGADCITM 920

Query: 264 TVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           TVSIG+   + +    T  F++L+  +D  LY +K  GRNR
Sbjct: 921 TVSIGISMYKNNKNLAT--FDELIELSDKALYTAKNSGRNR 959


>UniRef50_Q2LS38 Response regulator protein with GGDEF domain n=2 Tax=Syntrophus
           aciditrophicus SB RepID=Q2LS38_SYNAS
          Length = 356

 Score =  105 bits (262), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 69/230 (30%), Positives = 116/230 (50%), Gaps = 15/230 (6%)

Query: 84  VTGAVEIVLVANSVIDISVGSPFSIPQMFSARLG------IATMAICPIMVSFSVAAINS 137
           +T  +E+ L+    I   +GS  SI ++ S +         A   +   + +   + I  
Sbjct: 126 LTTLLELALIGTCFI--FLGSHSSINELLSLKYAGGMFAQFAPFVLVAYIATMFASDIRY 183

Query: 138 LMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVMLLDIDYFKSINDNYGH 194
            + +V + ++ D LT +Y+R G       L   S + ++ L+++L+D D  K IND YGH
Sbjct: 184 GLNKVKMMSETDELTGIYNRRGFAIVAGRLLGQSARYSRPLSLLLIDSDNLKKINDEYGH 243

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
             GD++L      IQ  +    ++AR GG+EF + +P   P   L +AE+IR  +E  P 
Sbjct: 244 HAGDQLLITLVNTIQAQLRHTDILARHGGDEFIILLPETPPSGALDVAERIRNAIETTPI 303

Query: 255 TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
             + K ++ T SIGV    ASY +   + + L+ +AD  +Y +K  GRNR
Sbjct: 304 VLEGKIVHTTASIGV----ASYPSEGYNIDVLLAQADHKMYAAKLGGRNR 349


>UniRef50_B9QWG6 GGDEF domain protein n=1 Tax=Labrenzia alexandrii DFL-11
           RepID=B9QWG6_9RHOB
          Length = 410

 Score =  105 bits (261), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 68/201 (33%), Positives = 103/201 (51%), Gaps = 7/201 (3%)

Query: 106 FSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK 165
           F+ P    A L +  +AI  +  SF   AI  +  +   +A  D LT + +R    +A K
Sbjct: 186 FANPIQPLAYLVLLMVAIVIVSASFVAMAIERIQVRFEKQALTDSLTGLANRRAFIKAAK 245

Query: 166 S--PSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGG 223
               S  QTQ  T++L+DID+FKSIND +GH  GD+VL+ F   ++ I        R+GG
Sbjct: 246 RWFSSTAQTQAFTLILIDIDHFKSINDQFGHTAGDRVLASFGTAMKSIFPRAIPPGRIGG 305

Query: 224 EEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDF 283
           EEFAV +P     D + +  ++R+ +       + +   +TVS G+ +   S+     DF
Sbjct: 306 EEFAVLLPETEKADAVHLLGRLREVISQCAICPKSEASGITVSAGLITATTSH-----DF 360

Query: 284 NKLMVEADTCLYRSKKDGRNR 304
            +    AD  LY +KK GRNR
Sbjct: 361 EQAFDHADQLLYEAKKTGRNR 381


>UniRef50_A8MM09 Diguanylate cyclase n=2 Tax=Clostridiaceae RepID=A8MM09_ALKOO
          Length = 356

 Score =  105 bits (261), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 70/197 (35%), Positives = 112/197 (56%), Gaps = 12/197 (6%)

Query: 114 ARLGIATMAICPIMVSFSVAAI---NSLMKQVALRADFDFLTQVYS---RSGLYEALKSP 167
           AR  +AT AI   +V F ++ I   N L  ++   A  DFLT +Y+      +   L + 
Sbjct: 162 ARYALAT-AIVSTVVYFVLSYIYRTNELYLRLKEEATRDFLTGLYNVREFEKVTNELFAT 220

Query: 168 SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFA 227
            +++ ++L+++++DID+FK +ND +GH  GD VL   +  I        +V+R GGEEF 
Sbjct: 221 IVQRKENLSLLMIDIDFFKKVNDTFGHSSGDLVLKQLSTIITSSCRSFDIVSRQGGEEFT 280

Query: 228 VAVPSVNPVDGLLMAEKIRKGVELQPFTW-QQKTLYLTVSIGVGSGRASYLTLTDDFNKL 286
           V +   +    L +AE+IRK VE   F   + + + +TVSIGV    +SY  +T+D + L
Sbjct: 281 VILLGCDHKTALEIAERIRKNVEDHLFIIDKNEEIKITVSIGV----SSYPEVTNDPHHL 336

Query: 287 MVEADTCLYRSKKDGRN 303
           + EAD  LY +K++GRN
Sbjct: 337 LHEADDALYFAKRNGRN 353


>UniRef50_B8KAR8 Ggdef family protein n=1 Tax=Vibrio parahaemolyticus 16
           RepID=B8KAR8_VIBPA
          Length = 323

 Score =  105 bits (261), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 68/196 (34%), Positives = 103/196 (52%), Gaps = 10/196 (5%)

Query: 113 SARLGIA-TMAICPIMVSFSVAAINSLMKQVAL--RADFDFLTQVYSRSGLYEALKSPSL 169
           SA L I   +  C I ++  +  +     + +L   A  D LT VY+R  L         
Sbjct: 121 SAHLAINFALTFCCIWLTSHILEVKRKTSEASLGQLASRDSLTGVYNRHALVHNFNRYHN 180

Query: 170 KQTQ-HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAV 228
           +  +  L++++LD+DYFK +ND YGH+ GDKVL   A  +  +  D+ LV R+GGEEF +
Sbjct: 181 ESAKVPLSLLILDLDYFKQVNDQYGHDVGDKVLVETAALLDALC-DEHLVYRIGGEEFCI 239

Query: 229 AVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMV 288
           A+ + N       AE IR+ +E   F+  +  + LTVSIGV           D    ++ 
Sbjct: 240 ALHNSNLQHAKYKAELIRQAIEQYSFSGAEAPIKLTVSIGVYECHH-----FDSLESVLK 294

Query: 289 EADTCLYRSKKDGRNR 304
           EAD  LY++KK+GRN+
Sbjct: 295 EADKELYKAKKNGRNQ 310


>UniRef50_C7RLV2 Response regulator receiver modulated diguanylate cyclase n=1
           Tax=Candidatus Accumulibacter phosphatis clade IIA str.
           UW-1 RepID=C7RLV2_9PROT
          Length = 639

 Score =  105 bits (261), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 64/161 (39%), Positives = 91/161 (56%), Gaps = 7/161 (4%)

Query: 149 DFLTQVYSRSGLYEALKSP-SLKQTQHLTV--MLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LTQ+ +R    + L S  +  Q+  L +  +LLDID+FK IND  GH  GD VL   A
Sbjct: 480 DTLTQLPNRRHGLDFLASEWAFAQSNALPMACLLLDIDHFKRINDTLGHPAGDAVLQQLA 539

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
             +++    + LV R GGEEFA  +P+ N    + +AE+IR  V+   F WQ++++ LTV
Sbjct: 540 DLLKRASRPEDLVFRYGGEEFAAVLPNANAQTAVQIAERIRGLVQKYDFLWQRRSIPLTV 599

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
           SIGV    A   +   D   L+  AD  LY++K  GRNR +
Sbjct: 600 SIGV----AILSSTGKDSQALIEAADAALYQAKNGGRNRVT 636


>UniRef50_B8DJ36 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfovibrio
           vulgaris str. 'Miyazaki F' RepID=B8DJ36_DESVM
          Length = 698

 Score =  105 bits (261), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 64/166 (38%), Positives = 89/166 (53%), Gaps = 15/166 (9%)

Query: 146 ADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLS 202
           A  D LT V +R      L+  + +  ++   L+V+LLD D+FKSIND +GHE GD VL 
Sbjct: 511 ATTDELTGVANRRHFMARLEDEAARAQRYGRPLSVLLLDADHFKSINDTWGHEAGDMVL- 569

Query: 203 VFARHIQKIVG----DKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQ 258
              RHI  ++G    +  L+ R+GGEEF V +P       L  AE+IR  VE  P   + 
Sbjct: 570 ---RHITDVMGLSLRENDLIGRLGGEEFGVLLPETAQERALRTAERIRAAVEDAPVAVRD 626

Query: 259 KTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
             +  TVS+G     A Y    D  + L+  AD  L R+K++GRNR
Sbjct: 627 VWVGCTVSVGA----AEYRGANDSLDDLIRRADHMLMRAKEEGRNR 668


>UniRef50_A1VD57 Diguanylate cyclase n=3 Tax=Desulfovibrio vulgaris
           RepID=A1VD57_DESVV
          Length = 487

 Score =  105 bits (261), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 62/186 (33%), Positives = 104/186 (55%), Gaps = 7/186 (3%)

Query: 122 AICPIMVSFSVAAINSLM-KQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTV 177
           A+  +M   ++A  N+++ +++ L+AD D LTQ+++R      L     +  ++   +T+
Sbjct: 288 ALDSVMRHLTLALRNAVVYREIKLQADHDALTQLHNRRSFDHRLAEEVDRHQRYGMPMTL 347

Query: 178 MLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVD 237
           ++LDID+FK++ND YGH  GD VL   A+ ++         AR GGEEF V +P  +   
Sbjct: 348 LMLDIDHFKAVNDTYGHPAGDAVLREVAQTMRNACRTTDFAARYGGEEFCVILPHTDGKC 407

Query: 238 GLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRS 297
           G + AE++RK +         KT+ +TVSIG+ +  A+     +   +L+ EAD  LY +
Sbjct: 408 GRIFAERLRKRLASSRVEVDGKTIAVTVSIGLATLSAAAPLSPE---RLVCEADGALYAA 464

Query: 298 KKDGRN 303
           K  GRN
Sbjct: 465 KAAGRN 470


>UniRef50_C6MHA0 Periplasmic/7TM domain sensor diguanylate cyclase n=1
           Tax=Nitrosomonas sp. AL212 RepID=C6MHA0_9PROT
          Length = 568

 Score =  105 bits (261), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 61/164 (37%), Positives = 93/164 (56%), Gaps = 8/164 (4%)

Query: 145 RADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVL 201
           RAD D LT + +R   Y+ ++   + SL+     +V++LDID FK +NDNYGH  GD VL
Sbjct: 402 RADIDLLTNLNNRRAFYKFVQPMWAISLRSKSSTSVIILDIDDFKLLNDNYGHPVGDLVL 461

Query: 202 SVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGV-ELQPFTWQQKT 260
              A  IQK      ++AR GGEEF + +P     D + +A+++RK +  +Q      + 
Sbjct: 462 VRLAETIQKEARSGDILARWGGEEFLIFLPETQLADAITIADRMRKRITTIQISIDNGEK 521

Query: 261 LYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           +  T S GV + +   ++L    N+L+ +AD  LY +KK GRNR
Sbjct: 522 ISFTASFGVATTQDINVSL----NELIAQADRQLYHAKKKGRNR 561


>UniRef50_Q6ALC0 Putative uncharacterized protein n=1 Tax=Desulfotalea psychrophila
           RepID=Q6ALC0_DESPS
          Length = 652

 Score =  105 bits (261), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 62/161 (38%), Positives = 94/161 (58%), Gaps = 10/161 (6%)

Query: 149 DFLTQVYSRSGLYEALKSPSLKQTQH-----LTVMLLDIDYFKSINDNYGHECGDKVLSV 203
           D LT + +RS L+E +    L++ +H     L++++LDIDYFK IND +GH  GD VL  
Sbjct: 493 DSLTGLCNRSQLFE-IAEAELERQRHSSEHNLSLVMLDIDYFKKINDAHGHAAGDLVLKA 551

Query: 204 FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL 263
           FA   +K + D  + AR+GGEEF + +P  +    L +AE+ R  VE  P    +K +  
Sbjct: 552 FADIGRKYLRDVDVFARIGGEEFIILLPGTDIKVALKIAERFRALVEKNPVMVNEKEIAF 611

Query: 264 TVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           TVS GV     ++  +   F +++ EAD+ LY +K+ GRNR
Sbjct: 612 TVSFGV----TAWNGIEQTFEEVLHEADSALYVAKEKGRNR 648


>UniRef50_A4CEZ1 Response regulator/GGDEF domain protein n=2 Tax=Alteromonadales
           RepID=A4CEZ1_9GAMM
          Length = 412

 Score =  105 bits (261), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 60/166 (36%), Positives = 94/166 (56%), Gaps = 10/166 (6%)

Query: 142 VALRADFDFLTQVYSRSGLYEALKSPSLK--QTQHLTVM-LLDIDYFKSINDNYGHECGD 198
           + L+A+ D+LT + +R   +E  +    K  Q QH T++ ++DID+FK+INDNYGH+ GD
Sbjct: 250 IRLQANSDYLTNLPNRRYFFEQTQLNIEKNVQAQHSTILAMIDIDFFKAINDNYGHDAGD 309

Query: 199 KVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQ 258
           +VL   A H  ++   + L+AR+GGEEFAV        +     E  R  VEL   ++  
Sbjct: 310 EVLKGLADHF-RLHFSEHLIARLGGEEFAVYFKQSTSAEASQQLEAFRMSVELNSPSFSS 368

Query: 259 KTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           K +  T+SIG+     +      + + ++  AD  LY++K DGRNR
Sbjct: 369 KKIPFTLSIGLADSNET------NVDAILKIADQYLYQAKSDGRNR 408


>UniRef50_Q0AQ22 Diguanylate cyclase n=2 Tax=Hyphomonadaceae RepID=Q0AQ22_MARMM
          Length = 350

 Score =  105 bits (261), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 64/185 (34%), Positives = 103/185 (55%), Gaps = 11/185 (5%)

Query: 128 VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLK---QTQHLTVMLLDIDY 184
            S  V  + + +++V   A  D LT + +R    E+L+        + Q L+++L DID+
Sbjct: 159 TSNEVTQLRTNLEKVREEAMTDALTGIANRKRFDESLRRARRDADTKKQPLSLILCDIDF 218

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEK 244
           FK  ND +GH+ GD+++   A  + +  G+  LVAR GGEEF + +P+  P     +AEK
Sbjct: 219 FKRFNDTWGHQTGDQIIRFVAGCLTRHAGENHLVARYGGEEFGIVMPNTAPNVAEQVAEK 278

Query: 245 IRKGVELQPF---TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
           IRK VE +     +  +    +TVS+G+    A+Y    +   +L+  +DT LYRSK +G
Sbjct: 279 IRKTVESKKLLRKSTNEDLGNITVSLGI----ATYHE-GESIEELIERSDTNLYRSKTEG 333

Query: 302 RNRTS 306
           RNRT+
Sbjct: 334 RNRTT 338


>UniRef50_B8IFL7 Diguanylate cyclase n=1 Tax=Methylobacterium nodulans ORS 2060
           RepID=B8IFL7_METNO
          Length = 628

 Score =  104 bits (260), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 62/174 (35%), Positives = 96/174 (55%), Gaps = 5/174 (2%)

Query: 137 SLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHEC 196
           ++  ++ ++A+ D LT + +R  L    +SP       + ++L+DID+FK+IND YGH  
Sbjct: 433 TMTSELRVQAETDGLTGLLNRRMLDRLAQSPPGSADDKVCLILIDIDHFKAINDTYGHAT 492

Query: 197 GDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTW 256
           GD+VL   A  +Q ++    ++AR GGEEFAV VP  +    + +A K+R  ++   FT 
Sbjct: 493 GDRVLIQMAELLQSVLRASDVIARFGGEEFAVLVPGADLSGAITVARKVRIALQRARFTT 552

Query: 257 QQKT-LYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
              T + +T S GV  GR       + +  L+  AD  LYR+K DGRNR    R
Sbjct: 553 PDGTPVRVTASFGVARGRRG----QEAWPCLVELADEALYRAKSDGRNRVRFAR 602


>UniRef50_Q0AV70 Response regulator receiver protein n=1 Tax=Syntrophomonas wolfei
           subsp. wolfei str. Goettingen RepID=Q0AV70_SYNWW
          Length = 459

 Score =  104 bits (260), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 61/173 (35%), Positives = 102/173 (58%), Gaps = 11/173 (6%)

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKSINDN 191
           +  L + + ++A  D LT +Y+   + E L+   + + +  Q LT+M+LDID+FKSIND 
Sbjct: 292 LRELNRILQVQAITDSLTGLYNHRQVLEKLQLEIARANRYQQELTIMMLDIDHFKSINDE 351

Query: 192 YGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVEL 251
           +GH+ GD VL   A+ I++ + +  +  R GGEEF + +P  N  +G  + E+IR+ VE+
Sbjct: 352 FGHQVGDVVLVEVAQIIKRNLRNIDIAGRYGGEEFLIILPQTNLNNGRQVGERIRRQVEI 411

Query: 252 QPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           + F   ++   +TVSIG+   +   +    D+   +  AD  LYR+K+ GRNR
Sbjct: 412 EGFEDSKEG--ITVSIGISQHQGEEMV---DY---IERADQLLYRAKRKGRNR 456


>UniRef50_B6BNA8 Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor
           n=3 Tax=Campylobacterales bacterium GD 1
           RepID=B6BNA8_9PROT
          Length = 460

 Score =  104 bits (260), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 67/206 (32%), Positives = 118/206 (57%), Gaps = 19/206 (9%)

Query: 104 SPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEA 163
           S F + ++ S+   +A++AI     S ++   N  +K++A++   D+LT +Y+RS L  +
Sbjct: 265 SDFEL-KLISSYAHLASLAIEKENHSKAIKESNERLKELAIK---DYLTGLYNRSKLDNS 320

Query: 164 LKSPSLKQTQHLTV---MLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVAR 220
           L+    +  ++ +V   +++DIDYFKS+ND +GH+ GDKVL  FA+ +  I  +  +V R
Sbjct: 321 LEYQIKRSKRYESVFGVIMMDIDYFKSVNDKHGHQVGDKVLLEFAKVLTDISRETDIVGR 380

Query: 221 MGGEEFAVAVPSVNPVDGLL-MAEKIRKGVELQPF-TWQQKTLYLTVSIGVGSGRASYLT 278
            GGEEF + + + +  DG+  +A KIR+ +E+  F   ++KT  L V+I           
Sbjct: 381 WGGEEFLIIIENADK-DGITNLAHKIRETIEMHDFPVVKRKTASLGVTI---------YN 430

Query: 279 LTDDFNKLMVEADTCLYRSKKDGRNR 304
             +  N+L+   D  LY++K  GRN+
Sbjct: 431 KDEKINELIGRVDKALYKAKNSGRNQ 456


>UniRef50_Q2BQS0 GGDEF family protein n=1 Tax=Neptuniibacter caesariensis
           RepID=Q2BQS0_9GAMM
          Length = 314

 Score =  104 bits (260), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 58/184 (31%), Positives = 100/184 (54%), Gaps = 7/184 (3%)

Query: 126 IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLT---VMLLDI 182
           I ++ ++     L +++   A+ D +T  Y+R    E++        ++ T   +  +DI
Sbjct: 133 IWLAINITEKKRLEQRLKDLAEKDPMTGAYNRRFFRESIDQHYATFKRYGTTYSLAFIDI 192

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           DYFK +ND +GH+ GD V+     HIQ+ +    L++R GGEEF V  P +N  +  L+A
Sbjct: 193 DYFKKVNDQFGHDVGDGVICHLVTHIQEQLRTTDLLSRFGGEEFVVLFPHINLDEACLVA 252

Query: 243 EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           E++R  +E+ P+      +  TVSIG+   RA   ++ D    ++  AD+ LY+SK  GR
Sbjct: 253 ERLRATIEMTPYKSINHKVPFTVSIGISEVRAEDESVED----ILKRADSALYQSKSSGR 308

Query: 303 NRTS 306
           N+ +
Sbjct: 309 NKVT 312


>UniRef50_C4WLB9 Diguanylate cyclase (GGDEF) domain-containing protein n=1
           Tax=Ochrobactrum intermedium LMG 3301 RepID=C4WLB9_9RHIZ
          Length = 379

 Score =  104 bits (260), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 61/163 (37%), Positives = 93/163 (57%), Gaps = 11/163 (6%)

Query: 146 ADFDFLTQVYSRSGLYEALKSPSLKQ--TQHLTVMLLDIDYFKSINDNYGHECGDKVLSV 203
           A  D LTQV +R G+   + S  L Q   + +T++L DID+FK +ND +GH  GD ++  
Sbjct: 217 AHTDPLTQVRNRRGMQAFISSVHLDQGAREPVTIVLADIDHFKMVNDRFGHHAGDMIIVD 276

Query: 204 FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKT--L 261
           FA+ +QK  G    VAR+GGEEFA+ +P  +   G+ + E +R  +E     W   +  L
Sbjct: 277 FAQLLQKWAGRGSCVARLGGEEFAILLPGTSMHIGVTLIEALR--LEFASRKWPHISAHL 334

Query: 262 YLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           +LT S G+     + L   + FN  +  ADT LY++K+ GR+R
Sbjct: 335 HLTASFGL-----TTLEQGEPFNSAIARADTNLYKAKQRGRDR 372


>UniRef50_C6BZK2 Diguanylate cyclase n=1 Tax=Desulfovibrio salexigens DSM 2638
           RepID=C6BZK2_DESAD
          Length = 383

 Score =  104 bits (260), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 66/174 (37%), Positives = 97/174 (55%), Gaps = 12/174 (6%)

Query: 133 AAINSLMKQVALRADFDFLTQVYSRSGLYEA---LKSPSLKQTQHLTVMLLDIDYFKSIN 189
           AA+  L K VA+    D LT V SR  + EA   +   +L+    L+V+++DID+FK +N
Sbjct: 198 AAMEDLKKLVAV----DELTGVCSRRRVLEAGDCIFKSALRFNNKLSVLMMDIDHFKKVN 253

Query: 190 DNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGV 249
           D++GH  GD+VL   A     ++ +     R+GGEEF V +P     DG+ +AE++R  V
Sbjct: 254 DDHGHCVGDEVLKETASRCSDVLREVDHFGRLGGEEFLVILPHSGVHDGIKVAERLRSCV 313

Query: 250 ELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
             + F   +  L ++VSIGV   R        DF  L+ EAD  LYR+KK GR+
Sbjct: 314 RERMFKVGESYLPVSVSIGVAELRGH-----GDFKSLIQEADEQLYRAKKCGRD 362


>UniRef50_A4VQQ9 GGDEF domain protein n=1 Tax=Pseudomonas stutzeri A1501
           RepID=A4VQQ9_PSEU5
          Length = 466

 Score =  104 bits (260), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 62/177 (35%), Positives = 95/177 (53%), Gaps = 7/177 (3%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKS 187
           S+A +     Q+A  A+ D LT V SR      L++   +  +H   L++++LDID+FK 
Sbjct: 291 SIARLRLAHGQLAQLANTDVLTGVSSRRAFLAGLEAELARARRHNESLSLLMLDIDHFKR 350

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           +ND +GH  GD VL  F+     ++    L+ R+GGEEFA+ +P  +      +AEKIR 
Sbjct: 351 VNDVHGHPIGDAVLKQFSETCAGMLRAHDLLGRLGGEEFAIVLPHTDAEGARCVAEKIRT 410

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
            V   P       + +TVSIG+    A    L  + ++LM  AD  LY +K+ GRN+
Sbjct: 411 AVAQTPMPTAAGDITVTVSIGL----AQMEGLPGEVDQLMARADQALYEAKRGGRNQ 463


>UniRef50_B3PIC1 Sensory box/GGDEF family protein n=5 Tax=Gammaproteobacteria
           RepID=B3PIC1_CELJU
          Length = 322

 Score =  104 bits (260), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 63/197 (31%), Positives = 103/197 (52%), Gaps = 26/197 (13%)

Query: 123 ICPIMVSFSVAAINSLMKQVALR-----ADFDFLTQVYSRS----------GLYEALKSP 167
           IC I+   +  A+N + +Q A +     +  D LT +++R             Y+  +SP
Sbjct: 131 ICVIIYDVTDTAVNKIAQQHANKQLQNLSRTDHLTSLFNRGYWELRLIQEFKRYDRYESP 190

Query: 168 SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFA 227
           S       ++++LDID+FK INDNYGH  GD+ +   +R I++ V D  +  R GGEEF 
Sbjct: 191 S-------SLIMLDIDHFKKINDNYGHTVGDEAIRCVSRVIKEQVRDLDIAGRYGGEEFG 243

Query: 228 VAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLM 287
           + + S N     ++AE++R  +E Q    +   ++ T+S+GV    A       D  + +
Sbjct: 244 IILTSTNGDGACVIAERLRSIIEKQTVYAEGHEIHFTISLGV----AELNDHMHDHRQWI 299

Query: 288 VEADTCLYRSKKDGRNR 304
            +AD  LY+SK+ GRNR
Sbjct: 300 EKADHALYKSKESGRNR 316


>UniRef50_B8JB86 Diguanylate cyclase n=4 Tax=Anaeromyxobacter RepID=B8JB86_ANAD2
          Length = 764

 Score =  104 bits (259), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 64/175 (36%), Positives = 94/175 (53%), Gaps = 15/175 (8%)

Query: 138 LMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHL----TVMLLDIDYFKSINDNYG 193
           L  Q    A  D LT + +     E L +  L Q Q      +++L DID+FKS+ND YG
Sbjct: 584 LFDQTERLATTDGLTGLTNHRTFQERLDA-HLGQAQRYGKRTSLLLCDIDHFKSVNDTYG 642

Query: 194 HECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP 253
           H  GD+VL   AR + +      +VAR GGEEFA+ +P  +    +++AE+IR+ V    
Sbjct: 643 HPVGDQVLRGVARTLARAARGTDVVARYGGEEFAIVMPETDTGGAMVIAERIREKVGQLV 702

Query: 254 FTWQQKTLYLTVSIGVGSGRASYLTLTDDFNK---LMVEADTCLYRSKKDGRNRT 305
           F  +Q  L +T+S+GV        T  DD  +   L+  AD CLY +K+ GRN++
Sbjct: 703 FETEQGPLKVTLSLGVA-------TFPDDGAQKPALIERADACLYHAKRHGRNQS 750


>UniRef50_Q21JG3 GGDEF domain n=1 Tax=Saccharophagus degradans 2-40
           RepID=Q21JG3_SACD2
          Length = 603

 Score =  104 bits (259), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 65/200 (32%), Positives = 106/200 (53%), Gaps = 12/200 (6%)

Query: 108 IPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK-- 165
           +P+ F    G    +I   MV  S+A + S M ++  ++  D LT++ +R    +     
Sbjct: 378 LPRTFFTENGFQIGSIIE-MVLLSLA-LGSRMTELKQQSHTDALTEIGNRRRFDDVFPVE 435

Query: 166 -SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGE 224
              + +  Q L ++++DIDYFK +ND +GH+ GD+ L   A  I+ +     L  R GGE
Sbjct: 436 FERAQRNKQPLALLMIDIDYFKKLNDTFGHDAGDQALRAVATTIKTLTRKPMLPCRFGGE 495

Query: 225 EFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFN 284
           EFAV +P  +     ++AE+IR+ +  +P   ++    +TVS+GV S    Y T +    
Sbjct: 496 EFAVILPRTDSAAAKIVAERIRQTIAEKPMAKRE----VTVSVGVASTDMGYFTSS---R 548

Query: 285 KLMVEADTCLYRSKKDGRNR 304
            +M  AD CLY +K+ GRNR
Sbjct: 549 AIMNAADECLYLAKEMGRNR 568


>UniRef50_B9M798 Diguanylate cyclase n=1 Tax=Geobacter sp. FRC-32 RepID=B9M798_GEOSF
          Length = 418

 Score =  104 bits (259), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 62/174 (35%), Positives = 100/174 (57%), Gaps = 11/174 (6%)

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLYEA--LKSPSLKQTQHLT--VMLLDIDYFKSIND 190
           +++ ++Q+A++   D LT +++R  +      K+ S ++   LT  V+ +D+DYFKS+ND
Sbjct: 246 VHAELEQMAIK---DELTGIFNRRHILSKANFKAISRQREGELTIGVLNMDVDYFKSVND 302

Query: 191 NYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVE 250
            YGH  GD+VL   +R +        L  R+GGEEF V +P     + + +AE+I + V 
Sbjct: 303 TYGHLVGDEVLKEISRRLTDSCRASDLAGRIGGEEFIVLLPDTAMTEIIAIAERIHRSVG 362

Query: 251 LQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
            +PF  +Q  L +T+S+GV    A  L    D ++ +  ADT LYR+K  GRNR
Sbjct: 363 EKPFHVEQHDLAVTISVGV----ACTLPGEKDLSQAIRRADTALYRAKNMGRNR 412


>UniRef50_Q47Y21 GGDEF domain protein n=1 Tax=Colwellia psychrerythraea 34H
           RepID=Q47Y21_COLP3
          Length = 722

 Score =  104 bits (259), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 58/159 (36%), Positives = 86/159 (54%), Gaps = 6/159 (3%)

Query: 149 DFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LT   +R    E L         H   L++MLLDID+FKS+ND YGH  GD+VL +F 
Sbjct: 561 DALTGAVNRHHFNEVLDQEIANVNNHGSPLSIMLLDIDHFKSVNDRYGHGVGDEVLVMFY 620

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
           +   + V    +VAR+GGEEF + +P+   V+    AE++R+ +           + +TV
Sbjct: 621 QTCVEAVRSSDVVARIGGEEFVIIMPNTQLVNAQKFAERLRQKIAKLELNIANNQISVTV 680

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           SIGV   ++ Y T  + F   +  AD  LY++K  GRN+
Sbjct: 681 SIGVSQWQSEYFTNAETF---VAHADKSLYQAKNSGRNK 716


>UniRef50_Q1YG68 GGDEF domain protein n=1 Tax=Aurantimonas manganoxydans SI85-9A1
           RepID=Q1YG68_MOBAS
          Length = 382

 Score =  104 bits (259), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 62/160 (38%), Positives = 88/160 (55%), Gaps = 9/160 (5%)

Query: 149 DFLTQVYSRSGLYEALKSPSLKQTQH----LTVMLLDIDYFKSINDNYGHECGDKVLSVF 204
           D LT + +R   Y+AL +  L Q +     +T++++D D+FK +ND YGHE GD+ L V 
Sbjct: 203 DALTGLANRRA-YDALIAEELAQRRGAEIGVTLLVVDFDHFKQVNDTYGHEAGDEALKVV 261

Query: 205 ARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLT 264
           +R ++  V +   V R GGEEF V +P      G   AE+IR  +E  P     + L LT
Sbjct: 262 SRILRSCVREGDYVCRHGGEEFTVILPQTGLPQGRRTAERIRHAIEAAPLIAGDQNLSLT 321

Query: 265 VSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           VSIGV +G   +    DD N L   AD  LY +K  GR++
Sbjct: 322 VSIGV-AGAPQH---GDDPNTLYRCADAALYEAKSAGRDQ 357


>UniRef50_A0Y2V2 GGDEF family protein n=3 Tax=Alteromonadales RepID=A0Y2V2_9GAMM
          Length = 524

 Score =  104 bits (259), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 62/165 (37%), Positives = 98/165 (59%), Gaps = 10/165 (6%)

Query: 141 QVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKV 200
           Q+   A  D LT  ++R  L   L    LKQT    ++ +DID+FK +ND +GH+ GD+ 
Sbjct: 365 QLKHDAQTDPLTNTHNRRSLNGLLSQLMLKQTP-FAILEIDIDFFKRVNDTFGHDKGDEA 423

Query: 201 LSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKT 260
           L V A  I+KI     +V+R+GGEEF + +P  +    L +AE++R  VE    T Q +T
Sbjct: 424 LKVLADIIKKISRKGDIVSRIGGEEFLLVLPHEDSQSALKIAERLRTTVE----TTQMET 479

Query: 261 L-YLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           + ++TVSIG+    A++ T +++ +++   AD  LY +K+ GRNR
Sbjct: 480 IGFITVSIGI----ATWPTHSNNIDQVYKCADKALYYAKEHGRNR 520


>UniRef50_A6WMZ7 Diguanylate cyclase n=3 Tax=Shewanella baltica RepID=A6WMZ7_SHEB8
          Length = 325

 Score =  104 bits (259), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 65/192 (33%), Positives = 100/192 (52%), Gaps = 11/192 (5%)

Query: 115 RLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK-SPSLKQTQ 173
           R  +AT   C I  +     IN   + +   A+ D LT   +R  L   L+ S    Q Q
Sbjct: 136 RFSVATFD-CIIFAAIFAHIINKQRQALVHLANTDELTGALNRKQLKTKLELSVYEYQQQ 194

Query: 174 HL--TVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVP 231
            +  +++L+DID+FK +NDN+GH  GD++L+ F++HIQK +    L+ R GGEEF + +P
Sbjct: 195 QIPASLLLIDIDFFKMVNDNFGHIMGDQLLNKFSQHIQKKIRKDDLLFRFGGEEFLILLP 254

Query: 232 SVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEAD 291
           +       ++AE +R+ +E Q F  Q     +T SIGV   R +     D  +  +   D
Sbjct: 255 NTQFESAAIVAEDLRRSIEEQHFLDQHTQ--VTCSIGVADLRQA-----DTLDTWLKTCD 307

Query: 292 TCLYRSKKDGRN 303
             LY +K  GRN
Sbjct: 308 NLLYNAKNAGRN 319


>UniRef50_A4Y784 Diguanylate cyclase n=18 Tax=Shewanella RepID=A4Y784_SHEPC
          Length = 368

 Score =  104 bits (259), Expect = 5e-21,   Method: Compositional matrix adjust.
 Identities = 69/180 (38%), Positives = 99/180 (55%), Gaps = 12/180 (6%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLK-QTQH--LTVMLLDIDYFKS 187
            V  + S M+ ++L A  D LT +Y+R     A++    + Q QH   +++++DID FK 
Sbjct: 190 EVQHLKSEMENLSLAAMTDQLTSLYNRRAYEIAIQDHIHRAQEQHSRCSLLIVDIDRFKQ 249

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
            ND YGH+ GDKVL+  A  +++ V     VAR GGEEF V +P+ +  D L +AE +R+
Sbjct: 250 FNDTYGHQIGDKVLAYVALALKQCVRGDDFVARYGGEEFVVLLPNTHFHDALQVAETLRE 309

Query: 248 GVELQPFT-WQQKTLYL---TVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
            +  +  T  + K L L   TVSIG+ S     L   DD   L   AD  LY +K DGRN
Sbjct: 310 RISERHLTIGKDKKLSLGAITVSIGLAS-----LQEGDDAETLFSRADKALYEAKSDGRN 364


>UniRef50_A0KEB8 Tetratricopeptide repeat family n=2 Tax=Aeromonas
           RepID=A0KEB8_AERHH
          Length = 596

 Score =  104 bits (259), Expect = 5e-21,   Method: Compositional matrix adjust.
 Identities = 61/160 (38%), Positives = 95/160 (59%), Gaps = 12/160 (7%)

Query: 146 ADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           A FD LT++ +R  L E L +   +Q   LT++++DID+FK IND +GH+ GD+ +   A
Sbjct: 429 ATFDQLTELPNRRALLERLAT-QWQQEGPLTLLIIDIDHFKQINDRHGHQAGDRAIQRLA 487

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
           R ++    D  LV R GGEEF VAVP +   D   +AE++R+ +       Q     +T+
Sbjct: 488 RELRSWAPDLQLVGRWGGEEFLVAVP-LPAADCWYLAEQLRQRI------GQIDKPRMTI 540

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
           SIGV +GR++     D   +L+  AD  +Y++K+ GRN+T
Sbjct: 541 SIGV-AGRSA---ADDGLGQLIHRADMAMYQAKRQGRNQT 576


>UniRef50_C8VW84 Response regulator receiver modulated diguanylate cyclase n=1
           Tax=Desulfotomaculum acetoxidans DSM 771
           RepID=C8VW84_DESAS
          Length = 314

 Score =  103 bits (258), Expect = 5e-21,   Method: Compositional matrix adjust.
 Identities = 58/173 (33%), Positives = 97/173 (56%), Gaps = 10/173 (5%)

Query: 135 INSLMKQVALRADFDFLTQVYSR----SGLYEALKSPSLKQTQHLTVMLLDIDYFKSIND 190
           +  L+++V   A  DFLT + +R      + E L   + +     +++++DID FK IND
Sbjct: 141 LQQLLQKVEQIAITDFLTGITNRRFAIDRMNEELSRIN-RGEDGFSLLMIDIDNFKDIND 199

Query: 191 NYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVE 250
           ++GHECGD +L      I+ ++ +  ++AR GGEEF V +PS    D  ++AEKI   V 
Sbjct: 200 SHGHECGDYILKDVVNLIKSVLRNYDMMARWGGEEFLVMLPSTEINDAKIVAEKIISNVR 259

Query: 251 LQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
            Q FT++  + ++T++ GV   +A      DD + ++  AD  +Y  KK G+N
Sbjct: 260 TQIFTYKGNSFHVTITAGVAQHQAG-----DDLDSIIKRADEAMYHGKKSGKN 307


>UniRef50_Q2BML0 Putative diguanylate cyclase (GGDEF domain) n=1 Tax=Neptuniibacter
           caesariensis RepID=Q2BML0_9GAMM
          Length = 577

 Score =  103 bits (258), Expect = 6e-21,   Method: Compositional matrix adjust.
 Identities = 57/162 (35%), Positives = 95/162 (58%), Gaps = 7/162 (4%)

Query: 146 ADFDFLTQVYSRSGL---YEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLS 202
           AD D LT +Y+R G     E +   + +  + L +++LDID+FK+IND +GH  GD VL+
Sbjct: 410 ADRDQLTGLYNRRGFDKVMEPVFGNAYRHHRELCLLVLDIDHFKAINDRHGHGYGDLVLT 469

Query: 203 VFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY 262
             A+ +Q  +    L+AR GGEEF + +P  N ++ + +AE++ + +  +         +
Sbjct: 470 DLAKVLQHELRAGDLIARWGGEEFLLLLPETNHMEAVTLAERLIRNISNREVEGDGVQEH 529

Query: 263 LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
            TVSIG+   +   ++    F +L+VEAD  LYR+K+ GRN+
Sbjct: 530 YTVSIGIAELKPPIVS----FKQLLVEADKHLYRAKETGRNK 567


>UniRef50_C0QRX3 Diguanylate cyclase/phosphodiesterase n=1 Tax=Persephonella marina
           EX-H1 RepID=C0QRX3_PERMH
          Length = 632

 Score =  103 bits (258), Expect = 6e-21,   Method: Compositional matrix adjust.
 Identities = 69/215 (32%), Positives = 109/215 (50%), Gaps = 16/215 (7%)

Query: 97  VIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRA-DFDFLTQVY 155
           V+D S+     I ++         + I  ++VSF V+       +  L+   +D LT  Y
Sbjct: 173 VLDFSIEKLHEIKKIVRKIQNALLIGISFVLVSFIVSIYQFFRYEKKLKKMYYDPLTGAY 232

Query: 156 SRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDK 215
           +R  LYE   +  L +    TV ++DID+FK IND YGHE GD VL    + I + + D 
Sbjct: 233 NRLFLYE---NSDLFKFYPFTVFVIDIDHFKKINDTYGHEIGDFVLKELTKRINRCIRDN 289

Query: 216 GLVARMGGEEFAVAVPSVNPV------DGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGV 269
            ++ R GGEEF + + + NPV      + L +A++I+  +E  PF  +   L +TVSIG+
Sbjct: 290 DILIRYGGEEFLLLIRA-NPVSPEYKKNILNLAKRIKNEIEFYPFDIENIKLKVTVSIGI 348

Query: 270 GSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
                ++        + +  AD  LY +K+ GRNR
Sbjct: 349 -----NFYEHEKSIEEAIKHADIALYSAKQKGRNR 378


>UniRef50_B8FMG8 Diguanylate cyclase n=1 Tax=Desulfatibacillum alkenivorans AK-01
           RepID=B8FMG8_DESAA
          Length = 417

 Score =  103 bits (258), Expect = 6e-21,   Method: Compositional matrix adjust.
 Identities = 67/203 (33%), Positives = 112/203 (55%), Gaps = 5/203 (2%)

Query: 108 IPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK-- 165
           I    +A + ++ +++  I+VS     +    + + + +  D LT++++R      L   
Sbjct: 209 IASGLTAAISLSLLSMIWILVSRLARRLTKAYETIEVMSITDELTRLHNRRHFETRLAEE 268

Query: 166 -SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGE 224
            S SL+    +++M+LDID+FK +NDNYGH+ GD VL+ FA  ++  V    + AR GGE
Sbjct: 269 ISRSLRYGSPMSLMILDIDHFKRVNDNYGHQAGDWVLTQFATLLKDNVRKADVPARWGGE 328

Query: 225 EFAVAVPSVNPVDGLLMAEKIRKGVELQPFTW-QQKTLYLTVSIGVGS-GRASYLTLTDD 282
           EF V +         + AEK+R+ VE   F     +++ +TVS+GV S    S   +  +
Sbjct: 329 EFVVILTESTISQARMAAEKVRRNVESAEFNIPDGRSIPVTVSVGVASLDMISGDEMGSE 388

Query: 283 FNKLMVEADTCLYRSKKDGRNRT 305
            + L+  AD  LYR+K++GRNRT
Sbjct: 389 ADVLVKTADDALYRAKQEGRNRT 411


>UniRef50_C1M322 Inner membrane protein yeaI n=1 Tax=Citrobacter sp. 30_2
           RepID=C1M322_9ENTR
          Length = 473

 Score =  103 bits (258), Expect = 6e-21,   Method: Compositional matrix adjust.
 Identities = 61/163 (37%), Positives = 96/163 (58%), Gaps = 18/163 (11%)

Query: 149 DFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHI 208
           D +T++Y+R   Y++LKS   K T  + VM+LDID FK IND YGH+ GD+V+      +
Sbjct: 316 DAMTKIYNRKLFYKSLKSSLAKGT--VCVMVLDIDKFKRINDTYGHQEGDRVIISIVDIV 373

Query: 209 QKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVEL-----QPFTWQQKTLYL 263
            K + D  + AR+GGEEFA+ +   +  + +++AE+IR+ VE        +  ++K   +
Sbjct: 374 NKSIRDTDIFARVGGEEFAILLKCNDKDEAIVVAERIRRNVENGTTIPNSYNLKEK---M 430

Query: 264 TVSIGVGSGRASYLTLTDD--FNKLMVEADTCLYRSKKDGRNR 304
           T+SIGV      Y +  DD   +K++  AD  LY +K  GRN+
Sbjct: 431 TISIGV------YCSKIDDESADKVVSYADAALYEAKNSGRNK 467


>UniRef50_A9AXN1 Diguanylate cyclase n=1 Tax=Herpetosiphon aurantiacus ATCC 23779
           RepID=A9AXN1_HERA2
          Length = 408

 Score =  103 bits (258), Expect = 6e-21,   Method: Compositional matrix adjust.
 Identities = 63/184 (34%), Positives = 94/184 (51%), Gaps = 19/184 (10%)

Query: 130 FSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLK---QTQHLTVMLLDIDYFK 186
           F+V     +   ++  A  D LT + +R  + E L+    K     Q   V++LDID FK
Sbjct: 202 FAVMITQRMQCDLSALASIDVLTGIANRRAINEYLEQAIAKWRRNQQGFAVIMLDIDCFK 261

Query: 187 SINDNYGHECGDKVLSVFARHIQKIVGDK----GLVARMGGEEFAVAVPSVNPVDGLLMA 242
            IND YGH  GD VL    RHI  ++ ++     L+ R GGEEF + V +       LMA
Sbjct: 262 QINDRYGHHAGDSVL----RHIALVLSEQVRINDLIGRWGGEEFLLIVDADTIQQATLMA 317

Query: 243 EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFN--KLMVEADTCLYRSKKD 300
           E++R+ ++ QP  W  + +  TVSIG+       +     FN  +L+  AD  LY +K+ 
Sbjct: 318 ERLRQAIQQQPTVWNDQVIQHTVSIGIA------VCGMHGFNEAQLLTAADLALYEAKET 371

Query: 301 GRNR 304
           G+NR
Sbjct: 372 GKNR 375


>UniRef50_C6WY37 Diguanylate cyclase n=1 Tax=Methylotenera mobilis JLW8
           RepID=C6WY37_METML
          Length = 395

 Score =  103 bits (258), Expect = 6e-21,   Method: Compositional matrix adjust.
 Identities = 69/190 (36%), Positives = 99/190 (52%), Gaps = 13/190 (6%)

Query: 127 MVSFSVAAINSLMKQVALRADF------DFLTQVYSRSGLYEA---LKSPSLKQTQHLTV 177
           ++ FSVA    LM    L AD       D LT   +R  + E    L++  ++  + L +
Sbjct: 200 LLEFSVAFGLLLMLNHRLIADVYQMASRDALTGAMNRRRIEEEAVRLRARCIRTGEPLAI 259

Query: 178 MLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVD 237
           M++DID+FKSIND YGH  GDKVL   A   QK +  +   AR GGEEF + + S    +
Sbjct: 260 MMIDIDFFKSINDRYGHPAGDKVLRAIADIAQKSIRAEDYFARYGGEEFCMLLTSTTESE 319

Query: 238 GLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRS 297
            L +AE++R        T  ++ L +TVSIGV       L    +F  ++  AD  LY +
Sbjct: 320 ALDLAERLRLAFAEFTLTLGKEQLNITVSIGVADSSMVGL----EFADMVTAADKALYCA 375

Query: 298 KKDGRNRTST 307
           K++GRNR  T
Sbjct: 376 KENGRNRVIT 385


>UniRef50_C7R8C4 Diguanylate cyclase n=1 Tax=Kangiella koreensis DSM 16069
           RepID=C7R8C4_KANKD
          Length = 700

 Score =  103 bits (258), Expect = 6e-21,   Method: Compositional matrix adjust.
 Identities = 64/183 (34%), Positives = 104/183 (56%), Gaps = 20/183 (10%)

Query: 134 AINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLK----QTQHLTVMLLDIDYFKSIN 189
           A+N  ++++++    D LT++Y+R G +EA  + + K        LT  +LDID+FK +N
Sbjct: 526 AMNERLEKMSVE---DELTKIYNRRG-FEAAANEAFKLACRNRTALTFAMLDIDHFKRVN 581

Query: 190 DNYGHECGDKVLSVFARHIQKI-VGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKG 248
           D +GH  GD+ + + A+ ++K+ + +    AR GGEEF V +   N      M E++RK 
Sbjct: 582 DTWGHVVGDECIVMVAKELKKVFLRETDFYARYGGEEFVVLLTGGNTDKHCRMLEQLRKD 641

Query: 249 VELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFN----KLMVEADTCLYRSKKDGRNR 304
           +E        + + LTVSIGV        +L +DFN    +L+ +AD  LY+SK +GRNR
Sbjct: 642 IENHKVAVDGENISLTVSIGV-------FSLKEDFNISYHQLVSKADKLLYQSKTEGRNR 694

Query: 305 TST 307
            S+
Sbjct: 695 ISS 697


>UniRef50_A0LSI3 Diguanylate cyclase n=1 Tax=Acidothermus cellulolyticus 11B
           RepID=A0LSI3_ACIC1
          Length = 517

 Score =  103 bits (258), Expect = 6e-21,   Method: Compositional matrix adjust.
 Identities = 67/192 (34%), Positives = 105/192 (54%), Gaps = 19/192 (9%)

Query: 131 SVAAINS-LMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFK 186
           ++A  NS L++Q+ L A  D LT V +R  L E L    + + +  Q ++V+++DID+FK
Sbjct: 331 ALALANSWLLEQITLLAATDMLTGVANRRTLEENLDRMFAQASRAAQPISVVMVDIDHFK 390

Query: 187 SINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIR 246
            IND +GH+ GD+ L   AR +Q+      LVAR GGEEF V +P  +       AE +R
Sbjct: 391 HINDTFGHQVGDQTLQRVARALQQGCRSSDLVARYGGEEFVVVLPDTDLAGAATAAENLR 450

Query: 247 K---GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           +   G++ +P         +TVS+GV    A++       + ++  AD  LY+SK  GRN
Sbjct: 451 RRIFGLDAEP--------RVTVSLGV----ATFPLHGGSPDHILSAADAALYQSKSAGRN 498

Query: 304 RTSTMRYGEEVV 315
           R +    G +V+
Sbjct: 499 RVTLAGVGSQVL 510


>UniRef50_A8FHG3 Possible diguanylate cyclase n=2 Tax=Bacillus pumilus
           RepID=A8FHG3_BACP2
          Length = 529

 Score =  103 bits (258), Expect = 6e-21,   Method: Compositional matrix adjust.
 Identities = 59/171 (34%), Positives = 89/171 (52%), Gaps = 12/171 (7%)

Query: 138 LMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECG 197
           L +++  RA  D LT +++RS   E  +    +  Q   VML DID+FK IND +GH  G
Sbjct: 352 LQEELERRAYIDGLTNIFNRSSFIERTQMILEEDAQDTAVMLFDIDFFKQINDTHGHHIG 411

Query: 198 DKVLSVFARHI----QKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP 253
           D+ L    RH+    Q+ +    L  R GGEEFA+ +P  +  +   +AE+IR   E+  
Sbjct: 412 DEAL----RHVVTICQQHLQMDDLFGRYGGEEFAICLPHHSFEEACHIAERIRHSFEMSF 467

Query: 254 FTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           F  +++ + +T S G+           +    L+ EAD  LY SK+ GRNR
Sbjct: 468 FENEEEKVRVTASFGIAHTAYD----PNVLETLLFEADQALYMSKRQGRNR 514


>UniRef50_Q1N6U5 Diguanylate cyclase (GGDEF domain) n=1 Tax=Bermanella marisrubri
           RepID=Q1N6U5_9GAMM
          Length = 564

 Score =  103 bits (258), Expect = 6e-21,   Method: Compositional matrix adjust.
 Identities = 62/182 (34%), Positives = 99/182 (54%), Gaps = 11/182 (6%)

Query: 128 VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDY 184
           V+   A +    +++ L +  D LT VY+R  L E ++   S + +     ++++LD+DY
Sbjct: 389 VAKRTAELEQKNEELRLLSSTDRLTGVYNRMKLEEQIQHEISRAQRYKLDYSIVMLDVDY 448

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEK 244
           FK++ND++GH+ GD+VL +FA  +Q  V +  +V R GGEEF ++    N  +   +AEK
Sbjct: 449 FKNVNDSFGHQVGDRVLKMFAVELQNNVRESDVVGRWGGEEFIISCSCTNADNAFSLAEK 508

Query: 245 IRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           +R+ +E   F      +  T S GV     S   L D    L+  AD  LY SK+ GRN+
Sbjct: 509 LREIIEHLDFG---SGIACTASFGV-----SQYQLEDSLESLISRADNALYESKRMGRNK 560

Query: 305 TS 306
            S
Sbjct: 561 VS 562


>UniRef50_A6VRQ0 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Marinomonas sp.
           MWYL1 RepID=A6VRQ0_MARMS
          Length = 469

 Score =  103 bits (258), Expect = 7e-21,   Method: Compositional matrix adjust.
 Identities = 66/204 (32%), Positives = 109/204 (53%), Gaps = 10/204 (4%)

Query: 106 FSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVAL--RADFDFLTQVYSRSGLY-- 161
           F+I + F +        +     + +  AI S   Q AL  RA FD LT++ +R   +  
Sbjct: 257 FAIYKRFPSTPSEKDFELINFASNLASIAIESFRAQEALQKRAYFDHLTELANRGYFFQQ 316

Query: 162 -EALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVAR 220
            E L + S ++   L ++++D+D+FK +ND +GH+ GD VL + A+    I+    L+AR
Sbjct: 317 CETLLNLSREKNFPLAILMMDVDHFKKVNDEFGHKTGDLVLQMLAQMSLSILRRDDLIAR 376

Query: 221 MGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQ-PFTWQQKTLYLTVSIGVGSGRASYLTL 279
           +GGEEFA+ +P     + L +AE++R+ +E     +   + +  TVS+GV   +    T+
Sbjct: 377 IGGEEFAILLPFTEKDEALRIAEQLRESIESSMVLSLDHQEVVFTVSLGVACRQDGDCTV 436

Query: 280 TDDFNKLMVEADTCLYRSKKDGRN 303
            D  NK    AD  LY++K  GRN
Sbjct: 437 DDILNK----ADKALYQAKAAGRN 456


>UniRef50_A6DDS7 Diguanylate cyclase (GGDEF domain) n=1 Tax=Caminibacter
           mediatlanticus TB-2 RepID=A6DDS7_9PROT
          Length = 750

 Score =  103 bits (258), Expect = 7e-21,   Method: Compositional matrix adjust.
 Identities = 63/178 (35%), Positives = 96/178 (53%), Gaps = 12/178 (6%)

Query: 130 FSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKS---PSLKQTQHLTVMLLDIDYFK 186
           + ++ I  L KQ+   A +D LT +Y+R+     LK     S +    L+++ LDIDYFK
Sbjct: 578 YQLSKIKKLSKQLETMAFYDKLTNIYNRAKFKNILKEFIEYSKRYKTPLSLIFLDIDYFK 637

Query: 187 SINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIR 246
            INDN+GHE GD VL    +  +  + +  +  R GGEEF + +P+ +     ++AEKIR
Sbjct: 638 KINDNFGHEKGDLVLKEMVKVAKLSLRESDVFGRWGGEEFLILLPNTDINGAKIVAEKIR 697

Query: 247 KGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
             +E   F      + +TVS+GV     + L   D     +  AD  LY++KK+GRNR
Sbjct: 698 DAIESHDFD----GIKVTVSLGV-----TQLKEDDTIESFVNRADIALYQAKKEGRNR 746


>UniRef50_C0N773 GGDEF domain protein n=1 Tax=Methylophaga thiooxidans DMS010
           RepID=C0N773_9GAMM
          Length = 462

 Score =  103 bits (258), Expect = 7e-21,   Method: Compositional matrix adjust.
 Identities = 62/174 (35%), Positives = 101/174 (58%), Gaps = 13/174 (7%)

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLYEALKSP--SLKQTQH-LTVMLLDIDYFKSINDN 191
           +N  ++Q++ R   D LT +++R  L +A +      K+ QH  T+++LDID FK IND+
Sbjct: 296 VNKKLEQLSQR---DHLTGIHNRYYLDQAFQQELTRYKRYQHGFTIVMLDIDLFKQINDS 352

Query: 192 YGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVEL 251
           YGH  GD V+   A  +++ V D+ +VAR GGEEF +  P  +      +AE +R+ +  
Sbjct: 353 YGHVVGDDVIKQIAMLLREHVRDQDVVARWGGEEFLILNPETSLDGARTLAEHLRRLIRR 412

Query: 252 QPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
            PFT  +  + +TVS GV   RA      +D   ++  AD+ LY++K+ GR++T
Sbjct: 413 TPFTVDK--IDVTVSFGVTDYRAG-----EDIETMIQRADSALYQAKQSGRDKT 459


>UniRef50_Q39ZK6 Response regulator receiver modulated diguanylate cyclase n=8
           Tax=Geobacter RepID=Q39ZK6_GEOMG
          Length = 314

 Score =  103 bits (258), Expect = 7e-21,   Method: Compositional matrix adjust.
 Identities = 58/163 (35%), Positives = 95/163 (58%), Gaps = 6/163 (3%)

Query: 149 DFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LT +++R  L E +     + ++    L++++LDIDYFK IND YGH+ GD+VL++ A
Sbjct: 145 DPLTHLHNRRHLMEMVDKEFQRSSRKGAPLSLVILDIDYFKKINDTYGHQEGDRVLTILA 204

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
             +++ +    L AR GGEEF + +P     + L +AE++R  V+   F      L +T+
Sbjct: 205 DIVRRRLRSYDLAARYGGEEFVLLLPETPVQEALSIAERLRLEVQEHVFEGSLGGLVITI 264

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
           S+GV +  +S +   +  + L  +AD  LYR+K+ GRNR   M
Sbjct: 265 SLGVATYPSSRV---ESIDSLFRQADEALYRAKQGGRNRVELM 304


>UniRef50_A6LR61 Diguanylate cyclase n=3 Tax=Clostridium RepID=A6LR61_CLOB8
          Length = 1784

 Score =  103 bits (258), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 59/167 (35%), Positives = 98/167 (58%), Gaps = 11/167 (6%)

Query: 142  VALRADFDFLTQVYSRSGLYEAL----KSPSLKQTQHLTVMLLDIDYFKSINDNYGHECG 197
            + + +  D LT VY+R    EAL     S   ++++   VM+ DID FK +ND YGH+ G
Sbjct: 1443 LTISSTLDKLTGVYNRKYFEEALLFLLDSAKARESE-FAVMMFDIDDFKGVNDKYGHQTG 1501

Query: 198  DKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ 257
            D+VL   A  ++K +    ++ R GGEEF + +P+VN    + + E+IRK +E       
Sbjct: 1502 DEVLVKVADEVKKCMSKGDIIGRYGGEEFIILLPNVNCEAAINLGERIRKNIEEARILGD 1561

Query: 258  QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
            ++   +TVSIG+    +SY +L ++  +++  AD  LY++K+DG+NR
Sbjct: 1562 KRK--VTVSIGI--AMSSYESLNNE--EIIRRADQALYKAKRDGKNR 1602


>UniRef50_Q5QV72 Intracellular signaling protein (PAS,GAF,GGDEF domains) n=2
           Tax=Idiomarina RepID=Q5QV72_IDILO
          Length = 453

 Score =  103 bits (257), Expect = 8e-21,   Method: Compositional matrix adjust.
 Identities = 64/174 (36%), Positives = 97/174 (55%), Gaps = 9/174 (5%)

Query: 137 SLMKQVALRADFDFLTQVYSR---SGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYG 193
           S  K++   A  DFLT + +R   +  +E L+    K        ++D+D+FK +NDNYG
Sbjct: 281 SKTKRLEKLAYTDFLTGLSNRLFITERFEELEPNDNKFANVTCFAIIDVDHFKKVNDNYG 340

Query: 194 HECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP 253
           H+ GD+VL   AR I  +V     V+R+GGEEFA+ +  +       + EK+R  +E   
Sbjct: 341 HDAGDEVLQQTARKIAGLVRISDCVSRVGGEEFALLLTDLPREKAERVLEKVRTAIEGNA 400

Query: 254 FTW-QQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
            T  + +++ +TVSIG     A+ L   D+FN    +AD  LY+SK+DGRNR S
Sbjct: 401 ITIDKNQSIKVTVSIG-----ATELKAEDEFNSAYKKADLALYKSKRDGRNRVS 449


>UniRef50_Q8D5C1 FOG: GGDEF domain n=1 Tax=Vibrio vulnificus RepID=Q8D5C1_VIBVU
          Length = 337

 Score =  103 bits (257), Expect = 8e-21,   Method: Compositional matrix adjust.
 Identities = 73/216 (33%), Positives = 112/216 (51%), Gaps = 25/216 (11%)

Query: 100 ISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAIN--------SLMKQVALRADFDFL 151
           +++   F + Q F     + TM I      FS+AAI         S   +++  A  D L
Sbjct: 133 VNITYQFYLEQYFD----MLTMMINFAFCYFSIAAIAHVYEFNRVSTENKLSKLATLDPL 188

Query: 152 TQVYSRSGL---YEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHI 208
           T   +R  L   Y+ALK+    Q     +++LDID+FK+IND YGH+ GD VL    + +
Sbjct: 189 TGTNNRLALKHRYQALKT----QGTAFFLLVLDIDHFKAINDEYGHDGGDCVLRSVVKTM 244

Query: 209 QKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIG 268
             +VG++  V R GGEEF + +  V+    L  AE IR+ +   P  +++  + +TVSIG
Sbjct: 245 AHVVGEEN-VFRQGGEEFCILLAGVSHQHALKTAETIRQNIGDTPIHYREGAISVTVSIG 303

Query: 269 VGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           +    AS  +  D+ N+   +AD  LY +K  GRNR
Sbjct: 304 LAEAHAS--SCVDEINR---QADANLYDAKSQGRNR 334


>UniRef50_A8H680 Diguanylate cyclase n=2 Tax=Shewanella RepID=A8H680_SHEPA
          Length = 261

 Score =  103 bits (257), Expect = 8e-21,   Method: Compositional matrix adjust.
 Identities = 61/174 (35%), Positives = 97/174 (55%), Gaps = 6/174 (3%)

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVMLLDIDYFKSINDN 191
           ++SL K++ L A  D LT++ +R   +   E     + ++ + L+V+ LD+D FK+IND 
Sbjct: 86  VDSLEKEMRLLASLDPLTELLNRRAFFRDAELYIHRAKQEGRMLSVIALDLDKFKAINDC 145

Query: 192 YGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVEL 251
           YGH  GD VL  F+  I+       L+ R+GGEEFA+ +P+ +      +AE++ + + L
Sbjct: 146 YGHSAGDAVLRHFSTTIRANCRTSDLMGRLGGEEFALLLPNTSASAAYALAERLHQALRL 205

Query: 252 QPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
               +   T+  TVSIGV S        TD+   L+ +AD  LY +K+ GRN T
Sbjct: 206 TAIQYGHSTMRYTVSIGVISVVPQK---TDNIEALLNKADRSLYLAKETGRNCT 256


>UniRef50_A9CEL7 GGDEF family protein n=1 Tax=Agrobacterium tumefaciens str. C58
           RepID=A9CEL7_AGRT5
          Length = 589

 Score =  103 bits (257), Expect = 8e-21,   Method: Compositional matrix adjust.
 Identities = 60/161 (37%), Positives = 88/161 (54%), Gaps = 14/161 (8%)

Query: 149 DFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHI 208
           D LT + +R  L EAL     K T  L  ++LDID+FK  ND +GH+ GD V+   A+ +
Sbjct: 431 DALTGLLNRRSLDEALNRHIEKPTGSLACLMLDIDHFKRFNDRFGHDAGDAVMQYVAQVL 490

Query: 209 QKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY-LTVSI 267
            +   D+G + R GGEEF V +P     D   +AEK+R  VE  PFT++ + L  +T+SI
Sbjct: 491 SEATSDQGTLFRFGGEEFTVLMPDAGIEDATKLAEKLRHAVERAPFTYRGRLLDPVTISI 550

Query: 268 GV----GSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           G+    G+G  S          ++  AD  L  +K+ GRN+
Sbjct: 551 GIATAPGAGTVS---------SVLERADAALLSAKQTGRNK 582


>UniRef50_B2JTM3 Diguanylate cyclase n=3 Tax=Burkholderia RepID=B2JTM3_BURP8
          Length = 202

 Score =  103 bits (257), Expect = 8e-21,   Method: Compositional matrix adjust.
 Identities = 62/181 (34%), Positives = 97/181 (53%), Gaps = 6/181 (3%)

Query: 133 AAINSLMKQVALRADFDFLTQVYSRSGLYE-ALKSPSLKQTQHLTVMLLDIDYFKSINDN 191
           AA++ ++ ++ L  D D LT+  +R      A +  + +++  L ++  DID FKSIND 
Sbjct: 17  AAMSDVIDRLTLERDLDSLTETLNRRAFERMAGRRVADRRSYPLALIAFDIDNFKSINDR 76

Query: 192 YGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVEL 251
           YGH  GD VL  FA  ++  V +K +VAR+GGEEF + +P  +      +AE++R  +E 
Sbjct: 77  YGHAAGDAVLRQFAAILRAAVREKDVVARIGGEEFVLLLPGADDKFAYQIAERLRIVLES 136

Query: 252 QPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYG 311
             F   + TL +T S G+   R       +    L+  AD  LY +K+ GRNR  T   G
Sbjct: 137 SRFNEIEATLRVTTSAGIARHRPG-----ETVGALLARADHLLYAAKRAGRNRVVTEPSG 191

Query: 312 E 312
           +
Sbjct: 192 Q 192


>UniRef50_A8VUQ7 Response regulator receiver protein n=1 Tax=Bacillus
           selenitireducens MLS10 RepID=A8VUQ7_9BACI
          Length = 610

 Score =  103 bits (257), Expect = 8e-21,   Method: Compositional matrix adjust.
 Identities = 60/171 (35%), Positives = 98/171 (57%), Gaps = 11/171 (6%)

Query: 139 MKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKSINDNYGHE 195
           +K +++R   D LT VY+R G  + +K   + +L++ + L+++ +DIDYFK  ND YGH+
Sbjct: 439 LKDLSVR---DPLTNVYNRGGFDQQMKAKWTEALQERKELSLLFVDIDYFKRYNDEYGHQ 495

Query: 196 CGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQ--P 253
            GD+ L   A  +Q+ +G+K +V+R GGEEF + +P  +       A  + K +  Q  P
Sbjct: 496 AGDQTLISVAHTLQEALGEKAIVSRYGGEEFVLILPGASEEQAASAAATLLKAIRDQQIP 555

Query: 254 FTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
            +  Q   Y+TVSIG   G +     TD  +  + +AD  LY +K+ GR+R
Sbjct: 556 HSQSQVAPYVTVSIG---GISRIPNETDKPDAFIKQADQALYAAKEAGRDR 603


>UniRef50_C9QDN5 Putative uncharacterized protein n=1 Tax=Vibrio orientalis CIP
           102891 RepID=C9QDN5_VIBOR
          Length = 457

 Score =  103 bits (257), Expect = 8e-21,   Method: Compositional matrix adjust.
 Identities = 66/189 (34%), Positives = 106/189 (56%), Gaps = 8/189 (4%)

Query: 117 GIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLT 176
           GI+   +  I+V+   AA N+  +++ L A  D LT++ +R   +E  +     + + L 
Sbjct: 264 GISAFIVQRIIVN-DCAARNAYEQKLYLEATTDPLTKLSNRRHFFEIGEQLVQNEMEPLA 322

Query: 177 VMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPV 236
           V+++DID+FK INDNYGH+ GD  LS FA    + +    ++ R+GGEEFA+ + +V+  
Sbjct: 323 VVIIDIDHFKKINDNYGHQVGDLALSRFAEMCCREIRASDIIGRIGGEEFAIILLNVDLA 382

Query: 237 DGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVG-SGRASYLTLTDDFNKLMVEADTCLY 295
               + E+IRK V    F  +  +L +T+S+GV  S +A  L        L+  AD  LY
Sbjct: 383 IVNEVTERIRKRVAESNFNSEVSSLSMTISLGVALSDQAHTL------EHLIKRADGALY 436

Query: 296 RSKKDGRNR 304
           ++K  GRNR
Sbjct: 437 QAKVSGRNR 445


>UniRef50_Q1JXC4 Diguanylate cyclase n=1 Tax=Desulfuromonas acetoxidans DSM 684
           RepID=Q1JXC4_DESAC
          Length = 637

 Score =  103 bits (257), Expect = 9e-21,   Method: Compositional matrix adjust.
 Identities = 64/190 (33%), Positives = 107/190 (56%), Gaps = 9/190 (4%)

Query: 126 IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEA---LKSPSLKQTQHLTVMLLDI 182
           I  S SV     LM  +   +  D +T +++R  L +    L + +L++ +++ +++ DI
Sbjct: 446 IKQSLSVLEAKRLMNTLRESSLRDPMTGLFNRRFLQDQAGHLIAGTLRRKKNIGLLMCDI 505

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           D+FK +ND YGH+ GD+VL   +  IQK V +  +V R GGEEF V +  +   D + +A
Sbjct: 506 DFFKQVNDQYGHDAGDQVLKETSAIIQKSVRESDVVVRFGGEEFLVILTDIEAGDAMSVA 565

Query: 243 EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           EKIR  +E + F    + +  T+S+GV    + Y   ++ F + +  AD  LYR+K+ GR
Sbjct: 566 EKIRSNIEDKVFMVGPEKIRKTISLGV----SEYPGDSEGFWQSIKYADVALYRAKETGR 621

Query: 303 NRTSTMRYGE 312
           NR   +R+ E
Sbjct: 622 NR--ALRFEE 629


>UniRef50_A9FZW1 FHA domain protein n=1 Tax=Sorangium cellulosum 'So ce 56'
           RepID=A9FZW1_SORC5
          Length = 299

 Score =  103 bits (256), Expect = 9e-21,   Method: Compositional matrix adjust.
 Identities = 59/159 (37%), Positives = 89/159 (55%), Gaps = 7/159 (4%)

Query: 149 DFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LTQ++++  LYEAL+   ++  +H   L ++L DID+FK IND +GH  GD VL   A
Sbjct: 142 DGLTQIHNKRYLYEALEREIIRGRRHERDLAILLFDIDHFKRINDVHGHLAGDFVLKEVA 201

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
           R +Q  +    + AR GGEEFA+ +P  +      + E +R+ V    F +Q  ++ +T+
Sbjct: 202 RIVQSRIRRDEVFARYGGEEFAIILPETSIEGAAALGETLRQKVAEHLFVFQADSIRVTI 261

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           S+GV   +    T  D    L+  AD  LY +K  GRNR
Sbjct: 262 SVGVALLQEGDRTAND----LIKRADERLYHAKNSGRNR 296


>UniRef50_A8ZXH2 Diguanylate cyclase n=3 Tax=Desulfococcus oleovorans Hxd3
           RepID=A8ZXH2_DESOH
          Length = 357

 Score =  103 bits (256), Expect = 9e-21,   Method: Compositional matrix adjust.
 Identities = 67/203 (33%), Positives = 107/203 (52%), Gaps = 12/203 (5%)

Query: 109 PQMFSARLGI---ATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEAL- 164
           P+  + +L I   A + +  + VS+    I +L +++   A FD LT+VY+R  ++E L 
Sbjct: 151 PEAVTVKLEIIRGAILVLSLLWVSYMANYIANLRRRIKEMASFDALTEVYNRREIFEILD 210

Query: 165 --KSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMG 222
             KS S +     ++ +LD+D FK +ND YGH+ GD+VL  FAR +++ V  +  V R G
Sbjct: 211 REKSFSDRSAIPFSLCILDLDDFKEVNDTYGHQAGDEVLKAFARALRENVRTEDYVGRYG 270

Query: 223 GEEFAVAVPSVNPVDG-LLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTD 281
           GEEF V   +    D  +   +++ K  E   F      L +T SIGV + R S     +
Sbjct: 271 GEEFLVVFVNFECRDNSVTCVDRLLKVTERLTFPGIADGLKITTSIGVSAYRPS-----E 325

Query: 282 DFNKLMVEADTCLYRSKKDGRNR 304
             + ++  AD  LY +K  G+NR
Sbjct: 326 TIDAVIARADQALYEAKAAGKNR 348


>UniRef50_D0I9J2 Diguanylate cyclase (GGDEF domain) with PAS/PAC sensor n=1
           Tax=Grimontia hollisae CIP 101886 RepID=D0I9J2_VIBHO
          Length = 498

 Score =  103 bits (256), Expect = 9e-21,   Method: Compositional matrix adjust.
 Identities = 65/181 (35%), Positives = 98/181 (54%), Gaps = 14/181 (7%)

Query: 131 SVAAINSLMKQVALRAD--FDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYF 185
           S+A I  +     L +D   D LT VY+R  + E  +    +  ++   L+++++D+D F
Sbjct: 311 SIAIIRDITDFKRLESDSMHDALTGVYNRRHIEERFEDEVKRAKRYARALSLLVVDLDNF 370

Query: 186 KSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKI 245
           K++ND  GH  GDK L V A H++  +     + R GG+EF V  P ++  D + +AE+I
Sbjct: 371 KNLNDTEGHRAGDKGLVVAAEHLRSQLRKHDHIGRWGGDEFVVICPELDRADAIEIAERI 430

Query: 246 RKGVELQPFTWQQKTLYLTVSIGVG--SGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           R+  E Q F W  K   +T+SIGV   S   S +T  D    L  EAD  LY +K+ GRN
Sbjct: 431 RRRFEAQQFPWCHK---MTMSIGVASLSPDTSVMTPRD----LFEEADQALYLAKERGRN 483

Query: 304 R 304
           R
Sbjct: 484 R 484


>UniRef50_C7R6L5 Diguanylate cyclase n=4 Tax=Gammaproteobacteria RepID=C7R6L5_KANKD
          Length = 393

 Score =  103 bits (256), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 58/171 (33%), Positives = 90/171 (52%), Gaps = 7/171 (4%)

Query: 137 SLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVMLLDIDYFKSINDNYG 193
           SL +++   A+ D LT V SR       EAL   S  +     + ++D+DYFK +ND +G
Sbjct: 224 SLEERLRTAAESDALTGVDSRGHFMQRAEALLQRSRFEKAPFCLFMIDVDYFKRVNDTWG 283

Query: 194 HECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP 253
           H CGD++LS  A   Q  +    ++ R GGEEF V +P+ N  +   +A++++  V    
Sbjct: 284 HTCGDQILSKIAEVCQHSLRPNDIIGRFGGEEFVVGLPNTNTSEAKAVADRLKDNVAALT 343

Query: 254 FTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
              +   L L+V+IG+        T  DD + L+  AD  LY  K++GRNR
Sbjct: 344 LDGEMSELRLSVTIGIAVAD----TEDDDLDVLITRADNMLYVGKREGRNR 390


>UniRef50_B8FCK6 Response regulator receiver modulated diguanylate cyclase n=1
           Tax=Desulfatibacillum alkenivorans AK-01
           RepID=B8FCK6_DESAA
          Length = 301

 Score =  103 bits (256), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 61/178 (34%), Positives = 101/178 (56%), Gaps = 11/178 (6%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKS 187
           S+   N  ++++A R   D LT +Y+     +A+      +++  + L+ +L DID+FK 
Sbjct: 127 SLQETNRQLQELANR---DGLTGLYNHRYFQDAMTKDFQRAMRYHESLSCVLCDIDFFKK 183

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
            ND YGH+ GD VLS  AR ++  + D  L AR GGEEFA+ +         ++AE++R+
Sbjct: 184 FNDTYGHQTGDIVLSTLARIVEDSLRDTDLAARYGGEEFALVLYHTPAAAAFMVAERLRE 243

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVE-ADTCLYRSKKDGRNR 304
            VE   F     +L +T+S+GV    A+Y       +K ++E AD  LY++K++GRN+
Sbjct: 244 SVEQHEFIANDLSLSVTISVGV----ATYPHPDIPDHKTLIECADKALYKAKENGRNQ 297


>UniRef50_C1A5L7 Putative two-component response regulator n=1 Tax=Gemmatimonas
           aurantiaca T-27 RepID=C1A5L7_GEMAT
          Length = 491

 Score =  103 bits (256), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 63/179 (35%), Positives = 95/179 (53%), Gaps = 11/179 (6%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKS 187
           S  A N+ ++Q+A     D LTQ+ +R  L E + +    +L+    L ++++D+D+FK 
Sbjct: 316 STMADNARLEQLA---QTDPLTQLLNRRALTERITAEMERALRYDSTLALLMIDLDHFKK 372

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           +ND YGH  GD VL    + +   +    + AR GGEEF V +P  +    +  AE+IR 
Sbjct: 373 VNDTYGHLVGDDVLRDVGQLLGHTIRGSDITARYGGEEFLVLLPETDDAGAVAFAERIRV 432

Query: 248 GVELQPFTWQQ--KTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
            +E  PF      + L LT SIGV    A+ +   +D   L   AD  LYR+K +GRNR
Sbjct: 433 AMEEHPFARDSMAEPLKLTASIGVAVFPAARIENVED---LFARADAALYRAKAEGRNR 488


>UniRef50_C6NZD9 Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF
           sensor(S) n=1 Tax=Sideroxydans lithotrophicus ES-1
           RepID=C6NZD9_9PROT
          Length = 1149

 Score =  103 bits (256), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 59/159 (37%), Positives = 90/159 (56%), Gaps = 8/159 (5%)

Query: 148 FDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVF 204
           FD LT + +R+ L E  K   S + +  + +TVM LD+D+FK IND  GH  GD++L   
Sbjct: 725 FDHLTGLPNRTQLNERFKYALSLAQRSGEQMTVMFLDLDHFKDINDTLGHSIGDQLLMDV 784

Query: 205 ARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLT 264
           A+ +++ + D+  V+R GG+EF + +P  +      +A K+ + V  Q F ++Q  L  T
Sbjct: 785 AKRLKETLRDEDTVSRQGGDEFILILPGTDENGAAHVAAKLMEAVS-QAFQFEQHELVAT 843

Query: 265 VSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
            SIG+    A Y    ++F  L   ADT +YR K DGRN
Sbjct: 844 CSIGI----AIYPHDGENFETLSKNADTAMYRVKHDGRN 878


>UniRef50_A6DDG0 Putative uncharacterized protein n=1 Tax=Caminibacter
           mediatlanticus TB-2 RepID=A6DDG0_9PROT
          Length = 235

 Score =  103 bits (256), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 59/178 (33%), Positives = 97/178 (54%), Gaps = 11/178 (6%)

Query: 129 SFSVAAINSLMKQVALRADFDFLTQVYSRSGLYE---ALKSPSLKQTQHLTVMLLDIDYF 185
           SF  +  N L+++++    FD+LT+ Y+R   ++    L + + ++ ++L ++++DIDYF
Sbjct: 58  SFETSLKNELLEKLSF---FDYLTEAYNRRAFFKFANILINDAKRENKNLALLMMDIDYF 114

Query: 186 KSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKI 245
           K IND YGHE GD VL  F   I+K +    L AR+GGEEF + +   N      +A KI
Sbjct: 115 KKINDTYGHEVGDIVLKEFVSLIKKNIRKNDLFARIGGEEFVLLIKINNEYQPYSIANKI 174

Query: 246 RKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
            K +E     ++   +  T+SIG      +    TD     + +AD  LY++ K+ RN
Sbjct: 175 LKLIETSQIIYKNYKIKFTISIGGYIFNPN----TDSLESALAKADKALYKA-KERRN 227


>UniRef50_Q31IH0 Diguanylate cyclase (GGDEF domain) n=1 Tax=Thiomicrospira crunogena
           XCL-2 RepID=Q31IH0_THICR
          Length = 349

 Score =  103 bits (256), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 61/173 (35%), Positives = 89/173 (51%), Gaps = 16/173 (9%)

Query: 146 ADFDFLTQVYSRSGLYE----ALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVL 201
           A  D LT + +R G  E     +K  + KQ+    +++LDID+FK +ND YGH  GD +L
Sbjct: 184 AKTDELTNIPNRRGFNEIIENMMKEANEKQSS-FALLVLDIDFFKKVNDTYGHLVGDSIL 242

Query: 202 SVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKT- 260
              A+ +      K  +AR+GGEEF   +PS +    L +A  IR+ +  +P   +    
Sbjct: 243 RYLAKSLHNETKGKDSIARIGGEEFVAILPSTSYDSALKLANTIREKIASRPLHVKNNAN 302

Query: 261 -LYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGE 312
            + LT+SIGV         L +  + L   AD CLY +K +GRNR     YGE
Sbjct: 303 PITLTISIGVA-----MFQLNETLDSLFTRADKCLYMAKSNGRNRV----YGE 346


>UniRef50_C7I2H1 Diguanylate cyclase n=1 Tax=Thiomonas intermedia K12
           RepID=C7I2H1_THIIN
          Length = 523

 Score =  103 bits (256), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 59/187 (31%), Positives = 102/187 (54%), Gaps = 9/187 (4%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY----EALKSPSLKQTQHLTVML 179
           C +     ++A   L +Q+   A  D LT + +R G +     AL++    Q     +ML
Sbjct: 338 CIVTGMVEISAQKHLEQQLRALAHTDPLTGLQNRRGFFAMVEHALRTRPAGQPGP-CIML 396

Query: 180 LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGL 239
           +D+D+FK IND YGH  GD++L  FA+ +  ++ +  + ARMGGEEF + +  +     L
Sbjct: 397 IDLDHFKQINDRYGHPVGDEILVEFAQVVLSLLREGDVFARMGGEEFCILLAHMRASQAL 456

Query: 240 LMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKK 299
            +AE++R+ V   PF      + L++S+G+    A   ++    ++++  AD  +YR+K+
Sbjct: 457 EVAERVREFVAAHPFQTSAGVVRLSLSLGIAGCDAPVQSI----DRVLSMADQAMYRAKQ 512

Query: 300 DGRNRTS 306
            GRNRT 
Sbjct: 513 GGRNRTE 519


>UniRef50_D0SXM5 Predicted protein n=2 Tax=Acinetobacter lwoffii SH145
           RepID=D0SXM5_ACILW
          Length = 440

 Score =  103 bits (256), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 57/162 (35%), Positives = 92/162 (56%), Gaps = 7/162 (4%)

Query: 146 ADFDFLTQVYSRSGLYEALKSPSLKQTQHLT--VMLLDIDYFKSINDNYGHECGDKVLSV 203
           A  D LTQ+Y+R    +  +    +  +H +  +++ D+D+FK+IND+YGH+ GD+VL +
Sbjct: 248 AHTDDLTQLYNRRHFVDMAERSIHQWPKHASSCLLMFDVDHFKNINDSYGHDVGDRVLQL 307

Query: 204 FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP-FTWQQKTLY 262
            A   +K +    ++AR GGEEF   +      D L++AE+IR  ++ Q  +     T+ 
Sbjct: 308 IAEVTRKEMRHSDVLARFGGEEFIALLEDTQLQDSLVIAERIRCAIQKQYIYVEPNHTIR 367

Query: 263 LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
            T+SIGV    +    L D    L+ +AD  LY++KK GRNR
Sbjct: 368 FTISIGVAELESHTQPLED----LIKQADIALYQAKKSGRNR 405


>UniRef50_C6CQG0 Diguanylate cyclase n=7 Tax=Enterobacteriaceae RepID=C6CQG0_DICZE
          Length = 491

 Score =  102 bits (255), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 57/174 (32%), Positives = 92/174 (52%), Gaps = 8/174 (4%)

Query: 134 AINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQ-TQHLT--VMLLDIDYFKSIND 190
            I +  +++ L A  D LT + +R       ++  +KQ TQH T  ++L+D+DYFK IND
Sbjct: 318 TIGAYQRRLELMATTDKLTGLMNRQAFEYVFRTLRIKQSTQHRTFSIILIDLDYFKKIND 377

Query: 191 NYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVE 250
            YGH  GD+VL   AR IQ+ +       R GGEEF + +   +      +AEKIR+ + 
Sbjct: 378 QYGHHVGDRVLVRTARLIQRTIRKTDSACRWGGEEFVLLLADCSRSQAHFIAEKIRRAIR 437

Query: 251 LQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
               + Q + + LT+S G+           +  + L+  AD  LY++K+ GR++
Sbjct: 438 FALVSHQHQVINLTISCGIAESHPG-----ESIDHLVQRADNALYQAKRQGRDQ 486


>UniRef50_A3Y6S3 PAS:GGDEF protein n=1 Tax=Marinomonas sp. MED121 RepID=A3Y6S3_9GAMM
          Length = 299

 Score =  102 bits (255), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 53/135 (39%), Positives = 83/135 (61%), Gaps = 6/135 (4%)

Query: 171 QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAV 230
           Q  H +++ LDIDYFK IND YGH  GD VL+ F+   +K +  +  +AR+GGEEF + +
Sbjct: 165 QNIHYSLLALDIDYFKRINDKYGHLTGDYVLASFSTLCEKNIRSQDKIARIGGEEFCIIL 224

Query: 231 PSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTD-DFNKLMVE 289
           P+ + V  + +AEK+R+ +    F   +  + +TVSIGV     S + ++D D+  ++  
Sbjct: 225 PATDKVGAIEVAEKLRRAISNARFKQDEHEIAVTVSIGV-----SQVKMSDYDYVAMLKR 279

Query: 290 ADTCLYRSKKDGRNR 304
           AD  LYR+K  GRN+
Sbjct: 280 ADENLYRAKHQGRNQ 294


>UniRef50_A9KNZ0 Diguanylate cyclase with GAF sensor n=1 Tax=Clostridium
           phytofermentans ISDg RepID=A9KNZ0_CLOPH
          Length = 573

 Score =  102 bits (255), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 60/198 (30%), Positives = 108/198 (54%), Gaps = 11/198 (5%)

Query: 110 QMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGL---YEALKS 166
           + F+  +      +  ++V+   A++ S M+Q+A+R   D LT +Y+R  L    E    
Sbjct: 360 EYFNGNIIFFETVVAQLLVAIHNASLYSKMQQMAIR---DSLTGIYNRGQLNVILEQYTK 416

Query: 167 PSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVG-DKGLVARMGGEE 225
            + +Q + L+V LLDID FK IND YGH  GD+V+ + A  +Q++     G+ AR GGEE
Sbjct: 417 RASEQNKSLSVALLDIDLFKKINDTYGHLFGDEVIKMVASKLQEVANCFHGIAARYGGEE 476

Query: 226 FAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNK 285
           F + +P +  +D   +   +++ ++     + +  + + VS+G+ S   + L+      +
Sbjct: 477 FVIVLPDIGILDFYHIVTSLKETIDTTTLYFNEDEINVKVSVGISSYPETSLSC----QQ 532

Query: 286 LMVEADTCLYRSKKDGRN 303
           L+  AD  +Y SK++GRN
Sbjct: 533 LLNRADGAMYYSKRNGRN 550


>UniRef50_C6X759 Diguanylate cyclase/phosphodiesterase n=1 Tax=Methylovorus sp.
           SIP3-4 RepID=C6X759_METSD
          Length = 765

 Score =  102 bits (255), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 62/164 (37%), Positives = 92/164 (56%), Gaps = 9/164 (5%)

Query: 145 RADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVL 201
           +A++DFLT + +R   ++ L      SL+  Q L +M LD+D FK IND  GH  GDK+L
Sbjct: 319 QANYDFLTGLPNRPMFHKQLAEEIHKSLQHQQPLVLMFLDLDNFKQINDQLGHSIGDKLL 378

Query: 202 SVFARHIQKIVGDKGLVARMGGEEFAVAVPSV-NPVDGLLMAEKIRKGVELQPFTWQQKT 260
                 I  +  D  L+AR+GG+EF + + +V N      + E+I + V L PFT +   
Sbjct: 379 VETGARIAAVARDCTLLARLGGDEFTIVLSNVQNQQQVEWLCERILRQVSL-PFTIENHV 437

Query: 261 LYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           +Y+T SIG+    AS+   + D   LM  AD  +Y +K+ GRNR
Sbjct: 438 VYVTTSIGI----ASFPEHSRDVETLMKYADQAMYEAKRLGRNR 477


>UniRef50_Q39S35 Diguanylate cyclase with GAF sensor n=2 Tax=Geobacter
           RepID=Q39S35_GEOMG
          Length = 686

 Score =  102 bits (255), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 74/206 (35%), Positives = 108/206 (52%), Gaps = 27/206 (13%)

Query: 117 GIATMAICPIMVSFSVAAINSLMKQVAL---RADF-------DFLTQVYSRSGLYEALKS 166
           GI T     ++++F+  A  S+M + AL   RADF       D LT +Y+R  L   ++ 
Sbjct: 466 GIFTENDLNLLITFADHA--SIMIERALSIERADFLEQLSITDPLTGLYNRRFLKRRMEE 523

Query: 167 P---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGG 223
               S++Q   LTVML+D+D FK  ND  GH  GD+ L   AR +        +V R GG
Sbjct: 524 ELARSIRQNLSLTVMLIDLDNFKIYNDLCGHLAGDRALKKMARILSDTARQMDVVTRYGG 583

Query: 224 EEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQK--TLYLTVSIGVGSGRASYLTLTD 281
           EEF + +P  +  + L +AE+IR+ +E + F+ ++      LT SIGV S         +
Sbjct: 584 EEFCIILPGTSKKESLFVAERIRREIEGEEFSHEENLPQGRLTASIGVSS-------FPE 636

Query: 282 DFN---KLMVEADTCLYRSKKDGRNR 304
           D N    L+  AD  LYR+K +GRNR
Sbjct: 637 DGNVEAVLVKAADVALYRAKSEGRNR 662


>UniRef50_B7KWW4 Diguanylate cyclase n=5 Tax=Methylobacterium RepID=B7KWW4_METC4
          Length = 417

 Score =  102 bits (255), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 63/164 (38%), Positives = 88/164 (53%), Gaps = 12/164 (7%)

Query: 146 ADFDFLTQVYSRSGLYEALK-----SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKV 200
           AD D LT + +R GL+ AL      SPS  +     ++L DID+FK+IND YGH+ GD  
Sbjct: 220 ADTDPLTGLANRRGLFAALSQRAGLSPSPPRC---AILLADIDHFKAINDTYGHDGGDAA 276

Query: 201 LSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKT 260
           L  FA  ++ ++    LVAR GGEEF V +   +      +AE++RK    QPFT     
Sbjct: 277 LVGFAERLRGVMRKDDLVARWGGEEFLVVLDQADATAAATVAERLRKSAAGQPFTVNGAA 336

Query: 261 LYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           + +T SIGV    A      +  +  +  AD  LY +K+ GRNR
Sbjct: 337 VTVTASIGVAVVAAG----EERIDAALSRADAALYAAKRAGRNR 376


>UniRef50_C1D6I3 Diguanylate cyclase n=1 Tax=Laribacter hongkongensis HLHK9
           RepID=C1D6I3_LARHH
          Length = 350

 Score =  102 bits (255), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 58/160 (36%), Positives = 91/160 (56%), Gaps = 4/160 (2%)

Query: 149 DFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LT +Y+R    + L+  + +  +H   L  ++LD D+FK IND +GH+ GD VL V A
Sbjct: 183 DPLTGLYNRRYFEQRLQEEAQRTRRHGDPLACLMLDADHFKRINDTWGHQAGDVVLKVLA 242

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
           R +++ +    + AR+GGEEFAV +PS       L+AE+IR  +  +P       + L V
Sbjct: 243 RRVRQQLRGCDVAARIGGEEFAVLLPSTPVRHVQLVAERIRLAIAGEPVHVSPDCV-LQV 301

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
           S+ +G+   +         +LM  AD  LY++K++GRNRT
Sbjct: 302 SVSLGAAMLAPGAADISPERLMARADAALYQAKRNGRNRT 341


>UniRef50_A7JY97 Ggdef domain protein n=8 Tax=Vibrio RepID=A7JY97_VIBSE
          Length = 682

 Score =  102 bits (255), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 54/138 (39%), Positives = 84/138 (60%), Gaps = 5/138 (3%)

Query: 167 PSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEF 226
           P   Q+  +++ L+D+DYFK +ND YGH  GD VL+  A+ +++ V +  +VAR GGEEF
Sbjct: 541 PKKPQSGPVSLALIDVDYFKQVNDTYGHVFGDAVLTGVAKVLEETVRENDIVARFGGEEF 600

Query: 227 AVAVPSVNPVDGLLMAEKIRKGVELQPF-TWQQKTLYLTVSIGVGSGRASYLTLTDDFNK 285
            V +P+ +  D L+ AE++R  + L  F T Q + + +T S GV +   S +    +F  
Sbjct: 601 VVVMPNTDHEDSLITAERLRSALSLHGFVTEQNEEVRVTCSFGVVTTEDSEM----NFKS 656

Query: 286 LMVEADTCLYRSKKDGRN 303
           L  +AD  LY++K DGRN
Sbjct: 657 LCDQADKLLYQAKADGRN 674


>UniRef50_Q7CYR0 GGDEF family protein n=4 Tax=Rhizobium/Agrobacterium group
           RepID=Q7CYR0_AGRT5
          Length = 356

 Score =  102 bits (255), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 68/176 (38%), Positives = 97/176 (55%), Gaps = 17/176 (9%)

Query: 132 VAAINSLMKQVALRADFDFLTQVYSRS-GLYEALKSPSLKQTQHLTVMLLDIDYFKSIND 190
           +A  +SL +    RA  D L  VY  S GL            Q+ T++LLDID+FK IND
Sbjct: 175 IANTDSLTRLSNRRAFDDRLASVYDSSIGL------------QYTTLVLLDIDHFKRIND 222

Query: 191 NYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVE 250
            +GH  GDK+L+  A  I+  V   G VAR GGEEFA+ +    P + ++M E+IR  +E
Sbjct: 223 TFGHPVGDKILATVASVIRANVRKDGFVARSGGEEFAIILDGNTPEEVMVMCERIRLSLE 282

Query: 251 LQPF-TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
             PF   +    Y TV+I +G   A+  +   + ++L   ADT LY +K+ GRNR+
Sbjct: 283 STPFRNSRSGADYGTVTISIGFASAARAS---NPSELYGHADTALYHAKETGRNRS 335


>UniRef50_UPI00016C5356 FHA domain protein n=1 Tax=Gemmata obscuriglobus UQM 2246
           RepID=UPI00016C5356
          Length = 294

 Score =  102 bits (255), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 59/160 (36%), Positives = 92/160 (57%), Gaps = 6/160 (3%)

Query: 148 FDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVF 204
            D LTQ++++  L E L+   ++  +H   L+V+ LDID FK+IND+ GH CGD +L   
Sbjct: 135 LDGLTQIHNKRYLDEFLEREVVRSQRHRRPLSVLALDIDKFKTINDSMGHLCGDFLLREL 194

Query: 205 ARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLT 264
           A  +++ V  + L AR GGEEF V +      D L +AE++R+ V    F ++   + +T
Sbjct: 195 AGVVRESVRQEDLFARAGGEEFVVVLVETTKDDALHVAERLREAVAAHEFRFEATPIKMT 254

Query: 265 VSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           +SIG+ S     +T     + L  +AD  LY +K+ GRNR
Sbjct: 255 ISIGLASTVGDEVTTP---HHLRQDADQKLYEAKRTGRNR 291


>UniRef50_C6RM00 Diguanylate cyclase n=5 Tax=Acinetobacter RepID=C6RM00_ACIRA
          Length = 527

 Score =  102 bits (255), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 58/174 (33%), Positives = 98/174 (56%), Gaps = 8/174 (4%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSIND 190
           S+   +S + ++    + D LTQ+++R G+ E      +    H +++L+DID FK +ND
Sbjct: 358 SIEKFSSKIDEMNFHINSDALTQLFNRRGM-EIFVKEMIDSDIHFSILLIDIDRFKRVND 416

Query: 191 NYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVE 250
            YGH+ GD+VL + A+ IQ+    + L  R GGEEF V +P+ N  +    AE+ R+ VE
Sbjct: 417 TYGHDIGDEVLKILAKLIQENFRKEDLCCRYGGEEFIVVIPNNNKQEIYESAERFRRIVE 476

Query: 251 LQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
                   +   +T+SIG+    AS+    ++F +++  AD  LY +K +GRN+
Sbjct: 477 AFEINNVGR---ITISIGI----ASWPDSAEEFAQVLKIADNNLYYAKNNGRNQ 523


>UniRef50_A7GXF8 3-deoxy-d-manno-octulosonic-acid transferase n=8
           Tax=Campylobacterales RepID=A7GXF8_CAMC5
          Length = 422

 Score =  102 bits (255), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 60/190 (31%), Positives = 103/190 (54%), Gaps = 11/190 (5%)

Query: 123 ICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVML 179
           IC   V+ ++ A+ ++  Q+A  A+ DFLT VY+R   Y+ +    + + +  +   + +
Sbjct: 241 IC--RVNNTIEAMENI-NQIANFANRDFLTSVYNRRYFYDDMTQYLAKAEETAEPYAIAM 297

Query: 180 LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGL 239
           +DID+FK+IND YGH+ GDKVL   A+ +        +VAR GGEEF V + +++  + +
Sbjct: 298 IDIDHFKNINDTYGHDSGDKVLQFLAKKLVDDTKGNDIVARFGGEEFCVVLKNISQEEAV 357

Query: 240 LMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKK 299
                +R  +     + ++  +  TVSIGV   R+ Y       ++L+  AD  LY +K+
Sbjct: 358 KFFVNLRAKIANSKISLKKNVINFTVSIGVVFNRSDYR-----LDELLELADEALYIAKE 412

Query: 300 DGRNRTSTMR 309
            GRNR    +
Sbjct: 413 SGRNRVEVAK 422


>UniRef50_B9JD30 Sensory box/GGDEF family protein n=12 Tax=Rhizobium/Agrobacterium
           group RepID=B9JD30_AGRRK
          Length = 466

 Score =  102 bits (255), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 59/167 (35%), Positives = 93/167 (55%), Gaps = 9/167 (5%)

Query: 149 DFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LT V +R GL + L      + + +  + V+L D+D+FK+IND YGH+ GD VL+ FA
Sbjct: 268 DMLTGVLNRRGLQDYLPLVVKKAARGSHKIAVLLFDLDHFKAINDRYGHQTGDTVLAEFA 327

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
           R  ++ + + G   RMGGEEF   +P  +  +   +AE +R  V   P    Q  +  TV
Sbjct: 328 RIGRQFIPESGAFGRMGGEEFIAFIPVADQAEAEAIAETVRAEVCRAPLLAGQSFVSATV 387

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGE 312
           S+G+    A     + ++++L+  AD  LY +K+ GRN   T+ +GE
Sbjct: 388 SVGL----AIMPCGSANWDRLVSAADRALYAAKRAGRN--CTVVFGE 428


>UniRef50_B8DLP9 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfovibrio
           vulgaris str. 'Miyazaki F' RepID=B8DLP9_DESVM
          Length = 730

 Score =  102 bits (255), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 61/162 (37%), Positives = 88/162 (54%), Gaps = 8/162 (4%)

Query: 146 ADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLS 202
           A  D LT + +R    EAL+    +  ++   L ++ +D+D FK +ND +GH  GD+VL 
Sbjct: 550 ATTDGLTGLANRRRFLEALEHEVQRHRRYGTPLALISIDVDRFKRVNDTWGHAVGDEVLR 609

Query: 203 VFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY 262
             A   +  V D   V R+GGEEFAV +P   P + + +AE++R GVE  P       L 
Sbjct: 610 ALAGICRAEVRDVDTVGRIGGEEFAVLLPDTAPEEAMAVAERLRAGVEAAPLLTTAGPLT 669

Query: 263 LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           +T+S+GV     S     D  + L+ EAD  LYR+K  GRNR
Sbjct: 670 VTLSLGV-----SASPPCDGADTLLREADRALYRAKAGGRNR 706


>UniRef50_Q9KAQ3 Response regulatory protein (Sensory transduction system) n=1
           Tax=Bacillus halodurans RepID=Q9KAQ3_BACHD
          Length = 314

 Score =  102 bits (255), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 53/159 (33%), Positives = 87/159 (54%), Gaps = 8/159 (5%)

Query: 149 DFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           DFLT + +R  + E +++    S++  +  T+ ++DID+FK+IND YGH+CGD VL  F 
Sbjct: 155 DFLTNLMNRRDMQEKIRAEINRSIRHGRSFTLAIVDIDFFKNINDTYGHDCGDHVLKHFV 214

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
             ++  V     V+R GGEEF +  P     +G    EKIR+ +   P  ++  ++ +T 
Sbjct: 215 STLKNSVRSSDYVSRWGGEEFLLLFPETKLEEGKRACEKIRQKINESPVIYKGMSISITA 274

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           + G+   R S         +L+  AD  LY+ KK G+N+
Sbjct: 275 TFGISEYRPSVR-----IEELIKAADDALYKGKKTGKNQ 308


>UniRef50_A3WKH9 Serine/threonine kinase with two-component sensor domain n=1
            Tax=Idiomarina baltica OS145 RepID=A3WKH9_9GAMM
          Length = 1632

 Score =  102 bits (255), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 61/177 (34%), Positives = 96/177 (54%), Gaps = 7/177 (3%)

Query: 131  SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPS--LKQTQH-LTVMLLDIDYFKS 187
             +A+ + + KQ+   A+ D LTQ+ +R      L+      K+  H   V+++DID FK 
Sbjct: 1454 EMASHDKVTKQLQHLANTDALTQLPNRRFFMSELQQSHDLFKRKGHQAAVVMMDIDSFKV 1513

Query: 188  INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
            IND YGH  GD+VL   A+     V    + AR+GGEEFA+ +   +    L +AE++R+
Sbjct: 1514 INDRYGHSAGDEVLKALAKQFNHAVRMNDIAARIGGEEFALLIRDADMPQVLAIAERLRQ 1573

Query: 248  GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
             +EL       + +  TVSIG+    + + T  D+F  ++  AD  LYR+K  G+NR
Sbjct: 1574 AIELDSIVHSGEEVDYTVSIGI----SLFETQDDEFESILNRADRALYRAKSLGKNR 1626


>UniRef50_Q47FH1 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Dechloromonas
           aromatica RCB RepID=Q47FH1_DECAR
          Length = 820

 Score =  102 bits (254), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 68/167 (40%), Positives = 90/167 (53%), Gaps = 14/167 (8%)

Query: 146 ADFDFLTQVYSRSGLYEALKSP--SLKQTQH-LTVMLLDIDYFKSINDNYGHECGDKVLS 202
           A  D LT++ +R    E L+     LK+T     V ++DID+FK IND YGHE GD VL 
Sbjct: 663 AHQDALTKLPNRLAANERLRQEFLRLKRTGSPYCVFMMDIDHFKMINDTYGHETGDHVLE 722

Query: 203 VFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY 262
            FA  +   +     VAR GGEEF   +P       ++ AEK+R  +  + F        
Sbjct: 723 HFAVTLTGALRATDFVARFGGEEFIALMPDTEIEGAMVAAEKVRIAIHQEKFP---VVGC 779

Query: 263 LTVSIGVGSGRASYLTLTDDFN--KLMVEADTCLYRSKKDGRNRTST 307
           +TVSIGVG+ R      T+D N  + +  AD  LYRSKKDGRNR S+
Sbjct: 780 VTVSIGVGNSR------TEDANEDETVRRADAALYRSKKDGRNRVSS 820


>UniRef50_A3QI98 Diguanylate cyclase n=1 Tax=Shewanella loihica PV-4
           RepID=A3QI98_SHELP
          Length = 401

 Score =  102 bits (254), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 55/178 (30%), Positives = 98/178 (55%), Gaps = 10/178 (5%)

Query: 134 AINSLMKQVALRADFDFLTQVYSRSGL---YEALKSPSLKQTQHLTVMLLDIDYFKSIND 190
           A+  L++++  +AD D+LT +++R  +    E L    L+  Q  +++L D+D+FK IND
Sbjct: 216 ALTRLVQKMRQQADRDYLTGLWNRRAMQQQLEQLHQRWLRDGQAYSLILFDLDFFKQIND 275

Query: 191 NYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVE 250
            +GH  GD VL   A+ I K+     +  R+GGEEF + +P  +     ++A+K+++ + 
Sbjct: 276 KFGHSAGDAVLVKTAQQIGKVTRAMDIFCRLGGEEFLLVLPGTDGEVAEIIAQKLQQALR 335

Query: 251 LQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDF-NKLMVEADTCLYRSKKDGRNRTST 307
                WQ   + ++ S G+ +      T T D  + L+  AD  +YR+K+ GR+R  T
Sbjct: 336 QSSLNWQGSLIPISASFGIVT------TATGDTPDSLLALADKAMYRAKETGRDRCCT 387


>UniRef50_B5JX81 Diguanylate cyclase n=1 Tax=gamma proteobacterium HTCC5015
           RepID=B5JX81_9GAMM
          Length = 384

 Score =  102 bits (254), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 87/286 (30%), Positives = 149/286 (52%), Gaps = 25/286 (8%)

Query: 36  QMMPAIALIVSVIASV--VIGGAGSLAFPLPALIWCAVR------YTPQVTCLLTFVTGA 87
           Q   A+ ++++  A V  V+ G   +   L   I    R      +T  +  L   +  A
Sbjct: 103 QFFVAVNMVLAYYAGVFSVVSGVALVGGSLTGFILFNERVVYGGLFTGALATLALIILSA 162

Query: 88  VEIVLVANSVIDISVGSPFSIPQMFSARL-GIATMAICPIMVSFSVAAINSLMK---QVA 143
           +E++  A SVI+ + G+P      +   L G++T  I  ++V+ + +AI    +   +V 
Sbjct: 163 LEVIPYA-SVIETN-GTPLHHNATWLILLLGLSTPYI-GLLVAMNSSAIRRWRQRESEVR 219

Query: 144 LRADFDFLTQVYSRSGLYE--ALKSPSLKQTQH--LTVMLLDIDYFKSINDNYGHECGDK 199
             +  D LTQV +R  L E   L+    +++ H  L+++++D+D+FKSIND +GH  GD+
Sbjct: 220 QLSTTDPLTQVANRRHLLERLNLEISRCERSGHSELSLLMMDLDHFKSINDEHGHLFGDE 279

Query: 200 VLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQ- 258
            L V AR +++   +  LV R GGEEF + +P   P   L +AE+ R+ +E      +  
Sbjct: 280 ALRVTARVLREQSRNTDLVGRYGGEEFCLLLPDTGPQGALQIAERCRQALEQADIDREDG 339

Query: 259 KTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           + L++T SIG+    A+Y  + D    L+  AD  LY++K+ GRNR
Sbjct: 340 EVLHITTSIGL----ATY-QMGDTNESLLHRADEALYQAKEQGRNR 380


>UniRef50_B9L7P4 Diguanylate cyclase/phosphodiesterase domain 1 n=1 Tax=Nautilia
           profundicola AmH RepID=B9L7P4_NAUPA
          Length = 614

 Score =  102 bits (254), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 60/165 (36%), Positives = 92/165 (55%), Gaps = 11/165 (6%)

Query: 145 RADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVF 204
           +++FD LTQ+Y+R G  E + +  +K+T   +++  DID+FK+INDNYGHE GD VL+  
Sbjct: 461 KSEFDALTQIYNR-GTIEKILNKKIKETDG-SLIFFDIDHFKNINDNYGHEKGDLVLASL 518

Query: 205 ARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLT 264
           AR IQK +       R GGEEF + +P         +AEK+RK +E   F      L +T
Sbjct: 519 ARIIQKNIRSSDYFGRWGGEEFVIILPQAPYEIAYKIAEKLRKIIEQTDFD----GLNIT 574

Query: 265 VSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
           +S+GV   +       D+   ++ + D  LY +K  GRN+    +
Sbjct: 575 ISLGVSEFKKG-----DNPEVVLKKVDEALYEAKNSGRNQVKGKK 614


>UniRef50_Q2RLY1 Diguanylate cyclase (GGDEF domain) n=1 Tax=Moorella thermoacetica
           ATCC 39073 RepID=Q2RLY1_MOOTA
          Length = 357

 Score =  102 bits (254), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 57/157 (36%), Positives = 90/157 (57%), Gaps = 6/157 (3%)

Query: 149 DFLTQVYSRSGLYEALKS--PSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFAR 206
           D LT +Y+     +A  +   S +Q ++L V++LDIDYFK IND YGH  G++VL+  A 
Sbjct: 189 DDLTGIYNYRYFVQAFSNLLNSRQQPRYLAVLMLDIDYFKEINDAYGHLTGNRVLAELAT 248

Query: 207 HIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVS 266
            +++   ++ +V R GGEEFA+ +P  +    L +AE+IRK +    F  +   +++TVS
Sbjct: 249 ILKECTREQDVVTRFGGEEFALILPDTDYHGALQVAERIRKAIAEHTFQAEGTAIHVTVS 308

Query: 267 IGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
            GV    A +     D   ++  AD  LY++K  GRN
Sbjct: 309 AGV----AVWPVDGTDKKDIIARADRALYQAKTTGRN 341


>UniRef50_C6DCR6 Diguanylate cyclase n=6 Tax=Pectobacterium RepID=C6DCR6_PECCP
          Length = 532

 Score =  102 bits (254), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 55/178 (30%), Positives = 102/178 (57%), Gaps = 8/178 (4%)

Query: 130 FSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSIN 189
           F    ++  + +++L+A  D LT + +R G+YE+++   L ++  +  +++DID+FK +N
Sbjct: 350 FGTLLLHKRIGKLSLQAHTDPLTGLLNRRGIYESIEL-ILPKSNQVAAIVIDIDHFKRVN 408

Query: 190 DNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGV 249
           D YGH  GD V+ + A+ I++   +  L+ R GGEEF   +P  +    + +AE++RK V
Sbjct: 409 DTYGHNIGDDVIRLLAKSIKQGSRESDLICRTGGEEFLALLPDTDMKQAVDIAERLRKKV 468

Query: 250 ELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
           E  P    +    +T+S+GV      ++   +  + ++  AD  LY++K +GRNR  T
Sbjct: 469 EKMPLPIPEN---ITISLGV----TCFIPGAEQIDNVLKIADDALYQAKHEGRNRVVT 519


>UniRef50_C8X2S3 Diguanylate cyclase n=1 Tax=Desulfohalobium retbaense DSM 5692
           RepID=C8X2S3_DESRD
          Length = 387

 Score =  102 bits (254), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 61/173 (35%), Positives = 97/173 (56%), Gaps = 7/173 (4%)

Query: 134 AINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSIND 190
           A+ S +++  L A  DFLT + +R G +EA      +  ++   L+V+LLD+D+FK +ND
Sbjct: 205 ALESTVQENRLLARTDFLTDLPNRRGFFEAGAKEIRRAHRYGRPLSVLLLDLDHFKKVND 264

Query: 191 NYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVE 250
            YGH+ GD VL+ F +  +  + +  L+AR+GGEEFAV +P     +   +AE +R+ VE
Sbjct: 265 VYGHDVGDHVLAQFGQKCRGRLREHDLMARLGGEEFAVLLPETPVAEASQVAEGLRRFVE 324

Query: 251 LQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
                   +   +TVSIGV           D  ++++   DT LY +K+ GRN
Sbjct: 325 GSSLAGVLEAGEVTVSIGV----CELAPQEDSLSEVLKRVDTALYMAKQAGRN 373


>UniRef50_B2A6L1 Response regulator receiver modulated diguanylate cyclase n=1
           Tax=Natranaerobius thermophilus JW/NM-WN-LF
           RepID=B2A6L1_NATTJ
          Length = 340

 Score =  102 bits (253), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 66/176 (37%), Positives = 102/176 (57%), Gaps = 12/176 (6%)

Query: 146 ADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLS 202
           A  D LTQ+ +R    E ++    +  ++   L+++LLDIDYFK+ ND YGH+ GD+ L 
Sbjct: 164 ATIDELTQLANRRLFDETMRGEWRRANRNGYNLSIILLDIDYFKNFNDAYGHQAGDECLK 223

Query: 203 VFARHIQKIVGDKG-LVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGV-ELQ-PFTWQQK 259
             A+ ++ ++   G   AR GGEEFAV +P  +      +AEKIR+G+ EL+ P    + 
Sbjct: 224 AIAKKLKFLMMRPGDFAARYGGEEFAVILPETDLRGAHSVAEKIRQGIEELKIPHCDSKV 283

Query: 260 TLYLTVSIGVGSG-----RASYLTLTDDFNKLMVE-ADTCLYRSKKDGRNRTSTMR 309
             Y+TVS+GV S      +      TDD  K+++E AD  LY++K +GRN  + M+
Sbjct: 284 AQYVTVSLGVASADLKNCQGGRDQATDDEIKILIEHADEALYKAKDNGRNTIALMQ 339


>UniRef50_A1TWC4 Diguanylate cyclase n=2 Tax=Acidovorax RepID=A1TWC4_ACIAC
          Length = 572

 Score =  102 bits (253), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 61/173 (35%), Positives = 92/173 (53%), Gaps = 8/173 (4%)

Query: 136 NSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKSINDNY 192
           + L+ Q+  ++  DFLT + +R   + A +   + + +Q   + +MLLD+D FKS ND  
Sbjct: 399 DGLIAQLREQSLTDFLTGLPNRRAFFAAARERIAQARQQRFDVALMLLDVDLFKSFNDRA 458

Query: 193 GHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQ 252
           GH  GD+ L   AR ++  +    LVAR GGEEF V +      +G   AE++R  +E  
Sbjct: 459 GHAAGDEALRAVARAVRHTLRPGDLVARYGGEEFVVLLGPCAGREGAACAERLRHAIETA 518

Query: 253 PFTWQQ-KTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           P      +   LT S+GV   +   + L    + L+ EADT LYR+K  GRNR
Sbjct: 519 PVVLPSGERFRLTASVGVAVSQRHGMVL----DHLLSEADTALYRAKDRGRNR 567


>UniRef50_A8UV88 Putative uncharacterized protein n=1 Tax=Hydrogenivirga sp.
           128-5-R1-1 RepID=A8UV88_9AQUI
          Length = 475

 Score =  102 bits (253), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 55/146 (37%), Positives = 85/146 (58%), Gaps = 5/146 (3%)

Query: 168 SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFA 227
           S +  + L+++++DID FKSINDNYGH+ GD VL   A  I+K V    + AR GGEEF 
Sbjct: 332 SKRYREPLSLLMMDIDNFKSINDNYGHDVGDLVLKKLAEVIRKNVRTSDIPARFGGEEFV 391

Query: 228 VAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLM 287
           V +P  +    L++AE+IR            K ++ +VSIG+     S L+  DD + L+
Sbjct: 392 VLLPRTDEKGALMVAERIRNEFRNSSVKVDGKDIWTSVSIGL-----SVLSEEDDIDSLI 446

Query: 288 VEADTCLYRSKKDGRNRTSTMRYGEE 313
            +AD  LY++K+ G++R    R  ++
Sbjct: 447 KKADEALYQAKRSGKDRVVIYREEDQ 472


>UniRef50_Q4ZZT3 GGDEF n=5 Tax=Pseudomonas syringae group RepID=Q4ZZT3_PSEU2
          Length = 690

 Score =  102 bits (253), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 62/169 (36%), Positives = 96/169 (56%), Gaps = 11/169 (6%)

Query: 139 MKQVALRADFDFLTQVYSRSGLYEALKSPSLK---QTQHLTVMLLDIDYFKSINDNYGHE 195
            +Q AL    D LT + +R+   E L+    +   +   L V +LD+D+FK IND YGH 
Sbjct: 526 QRQKAL---IDPLTGLPNRAAWGERLEREMARWHEEKNSLLVCILDLDHFKRINDGYGHL 582

Query: 196 CGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFT 255
            GDKVL + A  + K +     +AR GGEEF + +P+  P  GL + +++R  VE  PF 
Sbjct: 583 AGDKVLKIVANVLSKRLRADDFMARFGGEEFVMLLPATPPATGLKLLDELRAAVESCPFH 642

Query: 256 WQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           ++ + + +TVSIG+ + R S  + T      +  AD  LY++K++GRNR
Sbjct: 643 FKGERVTITVSIGMTAFRPSERSDT-----AIKRADQALYKAKENGRNR 686


>UniRef50_D1U463 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfovibrio
           aespoeensis Aspo-2 RepID=D1U463_9DELT
          Length = 974

 Score =  102 bits (253), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 61/195 (31%), Positives = 100/195 (51%), Gaps = 16/195 (8%)

Query: 125 PIMVS---FSVAAINSLMKQVALRADFDFLTQVYSRSG---------LYEALKSPSLKQT 172
           PIMV       + I+ + ++V L  +   L    S +G         L E     +++  
Sbjct: 783 PIMVQGNQLLYSVIHDITERVRLEREMKRLATTDSLTGAANRHEFFRLAELELRRAMRYG 842

Query: 173 QHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPS 232
             L V++LDIDYFKSIND +GH+ GD VL   +  ++  + D  +  R+GGEEFA  +P 
Sbjct: 843 HSLAVLMLDIDYFKSINDTHGHQTGDAVLKALSALVRTTLRDTDIFGRLGGEEFAAVLPE 902

Query: 233 VNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADT 292
            +   G+L+A+++R+ +       +   +  TVSIG+   R S   + D  N+    AD 
Sbjct: 903 TDLAGGVLVADRLRRELGALKVRLRDIEVMFTVSIGLTETRKSERLIDDAINR----ADE 958

Query: 293 CLYRSKKDGRNRTST 307
            +Y++K+ GRNR  +
Sbjct: 959 AMYKAKRMGRNRVES 973


>UniRef50_C4XS30 GGDEF domain protein n=1 Tax=Desulfovibrio magneticus RS-1
           RepID=C4XS30_DESMR
          Length = 498

 Score =  102 bits (253), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 58/171 (33%), Positives = 91/171 (53%), Gaps = 6/171 (3%)

Query: 140 KQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHEC 196
            QV +RAD D LT++++R    E L     +  ++   ++++++DID+FK IND YGH  
Sbjct: 313 NQVKIRADHDGLTRIHNRRAFDERLIDELRRHQRYRHAMSLLMVDIDHFKGINDRYGHLV 372

Query: 197 GDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTW 256
           GD VL      + + +      AR GGEEF V +P        ++AE++R  +    F  
Sbjct: 373 GDHVLREVGSILSETLRSTDFTARYGGEEFVVILPQTAEEQARILAERLRGAIAEARFVH 432

Query: 257 QQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
             +   +TVSIGV + +   LT   D   L+ +AD  LY++K  GRN+  T
Sbjct: 433 DGEDFSITVSIGVSALQPGALTRRKD---LLEKADKALYQAKHLGRNQVCT 480


>UniRef50_A3WM11 Signaling protein with a sensor domain and GGDEF domain n=1
           Tax=Idiomarina baltica OS145 RepID=A3WM11_9GAMM
          Length = 518

 Score =  102 bits (253), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 58/159 (36%), Positives = 89/159 (55%), Gaps = 7/159 (4%)

Query: 149 DFLTQVYSRSGLYEALK--SPSLKQTQH-LTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LT++ +R+ L E ++      K+T+  +++ +LDID+FK INDN+GH  GDK L V A
Sbjct: 355 DSLTKLPNRAALEERMRVEEQRFKRTKEPVSIAVLDIDFFKRINDNFGHSAGDKTLQVIA 414

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
             ++K V +   V R GGEEF V  P+    D     EK  + +   PF ++ + + +TV
Sbjct: 415 SMLRKAVNESDFVCRYGGEEFVVLFPNTPIADAQARLEKACERIRNIPFKFRSEDIRITV 474

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           S+G+   +    +LT  F      AD  LY +KK GRN+
Sbjct: 475 SVGIAELQQVNQSLTSLFET----ADNALYEAKKTGRNK 509


>UniRef50_Q7MFB4 GGDEF family protein n=2 Tax=Vibrio vulnificus RepID=Q7MFB4_VIBVY
          Length = 387

 Score =  102 bits (253), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 59/167 (35%), Positives = 92/167 (55%), Gaps = 12/167 (7%)

Query: 141 QVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKSINDNYGHECG 197
           Q +LR   D LT +Y+R  + E +    S + +    L++++LD+D+FK IND YGH+ G
Sbjct: 223 QTSLR---DTLTNIYNRRAMEEMIPRELSRASRLGAELSIIILDLDHFKRINDQYGHQVG 279

Query: 198 DKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ 257
           D+ LS   + +   +  + +  R+GGEEF V +P       +L+AEK+R+ +    F  +
Sbjct: 280 DQTLSGIGQLLTSQLRKQDISFRIGGEEFLVVLPDTPIESAVLVAEKLRQKIAETRFAPK 339

Query: 258 QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           Q+  + T S GV       L   DD++ LM  AD  LY +K  GRNR
Sbjct: 340 QRETW-TASFGVAQ-----LITGDDWDALMKRADAALYLAKHKGRNR 380


>UniRef50_A3SMA4 Diguanylate cyclase, putative/response regulator n=1
           Tax=Roseovarius nubinhibens ISM RepID=A3SMA4_9RHOB
          Length = 471

 Score =  102 bits (253), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 55/132 (41%), Positives = 78/132 (59%), Gaps = 5/132 (3%)

Query: 177 VMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPV 236
           VML D+D+FK+IND YGH  GD+VL   A H + I+ D  +VAR+GGEEF +  P V P 
Sbjct: 330 VMLADLDFFKNINDKYGHSGGDQVLRQVADHFRAILRDCDMVARIGGEEFLLVCPGVTPD 389

Query: 237 DGLLMAEKIRKGVELQ--PFTWQQKTLYLTVSIGVGSGRASYLTLT---DDFNKLMVEAD 291
           +    A++I + +     P T   + +++TVSIG+  GRA    L+    +  +L+  AD
Sbjct: 390 EARQTADRICREIADTAIPLTGYSQPVHITVSIGLVMGRAGRGELSPTGGESERLLARAD 449

Query: 292 TCLYRSKKDGRN 303
             LY SK  GRN
Sbjct: 450 AALYASKAHGRN 461


>UniRef50_A8VQE2 Putative diguanylate cyclase n=1 Tax=Bacillus selenitireducens
           MLS10 RepID=A8VQE2_9BACI
          Length = 301

 Score =  102 bits (253), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 65/178 (36%), Positives = 99/178 (55%), Gaps = 11/178 (6%)

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDN 191
           +  L+ Q  L A  D LT+VY++  + E L +    +L + Q   +++ DID+FKS+ND 
Sbjct: 128 MKRLLDQANLAAVTDELTRVYNKRYILEKLPADLTLALAEQQPFGLIVADIDHFKSVNDT 187

Query: 192 YGHECGDKVLSVFARHIQKIVGDKG-LVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVE 250
           YGH  GD++L  FA  ++    D+    AR GGEEF V +P  +    L +AE++R  +E
Sbjct: 188 YGHLAGDQILREFAAVLKDTCLDQADWTARFGGEEFVVCLPGKDRDTVLAVAERMRARIE 247

Query: 251 LQPFTWQQKTLYLTVSIGVGSGRASYLTLTD--DFNKLMVEADTCLYRSKKDGRNRTS 306
            Q F +  + + LT S GV +     L   D  D+  L+  AD  LY+SK+ GRNR +
Sbjct: 248 EQVFHYDGQAITLTSSFGVYA-----LAPGDVIDYETLLKRADQHLYQSKRTGRNRVT 300


>UniRef50_A0XYM4 Putative uncharacterized protein n=1 Tax=Alteromonadales bacterium
           TW-7 RepID=A0XYM4_9GAMM
          Length = 302

 Score =  102 bits (253), Expect = 3e-20,   Method: Compositional matrix adjust.
 Identities = 58/156 (37%), Positives = 84/156 (53%), Gaps = 11/156 (7%)

Query: 149 DFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHI 208
           D LTQVY+R   YE +++ +    +   V+++DID+FKSIND +GH+ GDKVL  FA  I
Sbjct: 151 DDLTQVYNRRCFYEYVENET---DESYAVIIIDIDHFKSINDTFGHDKGDKVLKAFASKI 207

Query: 209 QKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIG 268
             +  D  + AR+GGEEFA  +P+         AE +         T     LY + SIG
Sbjct: 208 DALFEDGNIFARIGGEEFAGYLPNCTLEQMQAFAESVLASARTIEVT---DELYTSASIG 264

Query: 269 VGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           V     +     + F+ +M  AD  LY++K  GRN+
Sbjct: 265 VAKRFKN-----ESFDSVMKRADQALYKAKNSGRNQ 295


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q8XAZ4 Uncharacterized protein yneF n=65 Tax=Enterobact...   471   e-131
UniRef50_D2TIF8 Putative signal transduction protein n=2 Tax=Ent...   421   e-116
UniRef50_A8A075 Diguanylate cyclase (GGDEF) domain protein n=2 T...   414   e-114
UniRef50_B1JAS6 Diguanylate cyclase n=5 Tax=Pseudomonas RepID=B1...   316   7e-85
UniRef50_C8QCH2 Diguanylate cyclase n=1 Tax=Pantoea sp. At-9b Re...   313   4e-84
UniRef50_C6CDM3 Diguanylate cyclase n=1 Tax=Dickeya dadantii Ech...   302   1e-80
UniRef50_D0IXN6 Diguanylate cyclase n=2 Tax=Comamonas testostero...   299   1e-79
UniRef50_A0P392 GGDEF domain protein n=1 Tax=Labrenzia aggregata...   297   4e-79
UniRef50_D0FTB2 Conserved uncharacterized protein YneF n=3 Tax=E...   295   1e-78
UniRef50_C6CM30 Diguanylate cyclase n=1 Tax=Dickeya zeae Ech1591...   290   3e-77
UniRef50_D2C311 Diguanylate cyclase n=1 Tax=Dickeya dadantii Ech...   288   2e-76
UniRef50_A8GAZ5 Diguanylate cyclase n=2 Tax=Serratia RepID=A8GAZ...   287   5e-76
UniRef50_D0S942 Response regulator n=2 Tax=Acinetobacter RepID=D...   280   5e-74
UniRef50_B7GZC2 Uncharacterized protein yneF n=10 Tax=Acinetobac...   270   4e-71
UniRef50_A8GES9 Diguanylate cyclase n=2 Tax=Serratia RepID=A8GES...   268   1e-70
UniRef50_C6DKF8 Diguanylate cyclase n=5 Tax=Pectobacterium RepID...   268   2e-70
UniRef50_A9C2H0 Diguanylate cyclase n=2 Tax=cellular organisms R...   268   2e-70
UniRef50_C6RK39 Diguanylate cyclase n=2 Tax=Acinetobacter radior...   267   3e-70
UniRef50_C3JIZ7 Diguanylate cyclase n=2 Tax=Rhodococcus erythrop...   263   4e-69
UniRef50_C6DJJ8 Diguanylate cyclase n=1 Tax=Pectobacterium carot...   259   1e-67
UniRef50_D0KF92 Diguanylate cyclase n=1 Tax=Pectobacterium wasab...   253   5e-66
UniRef50_C3JRE9 Diguanylate cyclase n=2 Tax=Rhodococcus erythrop...   252   1e-65
UniRef50_Q2RNW0 Putative diguanylate cyclase (GGDEF domain) n=1 ...   250   6e-65
UniRef50_C7LVZ4 Diguanylate cyclase n=1 Tax=Desulfomicrobium bac...   249   9e-65
UniRef50_Q2SME0 Response regulator containing a CheY-like receiv...   249   1e-64
UniRef50_A8FZ07 Diguanylate cyclase n=2 Tax=Shewanella RepID=A8F...   248   1e-64
UniRef50_D1U9C4 Diguanylate cyclase n=1 Tax=Desulfovibrio aespoe...   247   3e-64
UniRef50_Q4KDW8 GGDEF domain protein n=6 Tax=Pseudomonas RepID=Q...   246   9e-64
UniRef50_B5JX81 Diguanylate cyclase n=1 Tax=gamma proteobacteriu...   245   1e-63
UniRef50_A8V0B5 Diguanylate cyclase (GGDEF domain) n=1 Tax=Hydro...   245   1e-63
UniRef50_Q310L5 Diguanylate cyclase (GGDEF domain) n=2 Tax=Desul...   245   1e-63
UniRef50_B8DLP9 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   245   2e-63
UniRef50_A3WKT4 GGDEF domain protein n=2 Tax=Alteromonadales Rep...   245   2e-63
UniRef50_C4XS30 GGDEF domain protein n=1 Tax=Desulfovibrio magne...   243   7e-63
UniRef50_D2L2K3 Diguanylate cyclase with GAF sensor n=1 Tax=Desu...   243   7e-63
UniRef50_Q1N175 Diguanylate cyclase (GGDEF domain) n=1 Tax=Berma...   241   2e-62
UniRef50_C6BW86 Diguanylate cyclase n=1 Tax=Desulfovibrio salexi...   241   3e-62
UniRef50_B1WQB8 Putative diguanylate cyclase n=2 Tax=Cyanothece ...   240   7e-62
UniRef50_B3EBI3 Diguanylate cyclase n=1 Tax=Geobacter lovleyi SZ...   240   8e-62
UniRef50_D1U434 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   239   8e-62
UniRef50_C0QM24 Putative uncharacterized protein n=1 Tax=Desulfo...   238   2e-61
UniRef50_C8X5B9 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   238   2e-61
UniRef50_B8FCK6 Response regulator receiver modulated diguanylat...   238   2e-61
UniRef50_B8FMG8 Diguanylate cyclase n=1 Tax=Desulfatibacillum al...   238   2e-61
UniRef50_A0LD73 Diguanylate cyclase n=1 Tax=Magnetococcus sp. MC...   238   2e-61
UniRef50_C6WYA9 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   237   3e-61
UniRef50_A5GCU4 Diguanylate cyclase n=2 Tax=Geobacter RepID=A5GC...   237   3e-61
UniRef50_Q47W79 GGDEF domain protein n=1 Tax=Colwellia psychrery...   237   4e-61
UniRef50_C1A5L7 Putative two-component response regulator n=1 Ta...   237   4e-61
UniRef50_A4VQQ9 GGDEF domain protein n=1 Tax=Pseudomonas stutzer...   236   6e-61
UniRef50_A6DDS7 Diguanylate cyclase (GGDEF domain) n=1 Tax=Camin...   236   6e-61
UniRef50_C0QT79 Signal transduction response regulator n=1 Tax=P...   236   7e-61
UniRef50_C6BU46 Diguanylate cyclase n=1 Tax=Desulfovibrio salexi...   236   8e-61
UniRef50_Q07Y51 Diguanylate cyclase n=2 Tax=Alteromonadales RepI...   235   2e-60
UniRef50_C7LRA7 Diguanylate cyclase n=1 Tax=Desulfomicrobium bac...   235   2e-60
UniRef50_C4LFT4 Diguanylate cyclase n=1 Tax=Tolumonas auensis DS...   234   3e-60
UniRef50_C6C0X5 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   234   3e-60
UniRef50_C6BVV0 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   234   4e-60
UniRef50_Q15V65 Diguanylate cyclase n=1 Tax=Pseudoalteromonas at...   234   4e-60
UniRef50_Q4KKJ4 Diguanylate cyclase, putative n=5 Tax=Pseudomona...   234   4e-60
UniRef50_Q39ZK6 Response regulator receiver modulated diguanylat...   234   4e-60
UniRef50_D0SXM5 Predicted protein n=2 Tax=Acinetobacter lwoffii ...   234   4e-60
UniRef50_Q489Q4 Sensory box/GGDEF domain protein n=1 Tax=Colwell...   233   4e-60
UniRef50_Q2BQS0 GGDEF family protein n=1 Tax=Neptuniibacter caes...   233   5e-60
UniRef50_A8UV88 Putative uncharacterized protein n=1 Tax=Hydroge...   233   5e-60
UniRef50_A3Y6S3 PAS:GGDEF protein n=1 Tax=Marinomonas sp. MED121...   233   5e-60
UniRef50_A3WKY5 Signaling protein with a ligand-binding sensor d...   233   6e-60
UniRef50_Q2SNU2 Response regulator containing a CheY-like receiv...   233   6e-60
UniRef50_A1ASG6 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   233   7e-60
UniRef50_C0N773 GGDEF domain protein n=1 Tax=Methylophaga thioox...   233   7e-60
UniRef50_Q085X7 Diguanylate cyclase n=2 Tax=Alteromonadales RepI...   233   7e-60
UniRef50_Q0A9X2 Diguanylate cyclase n=3 Tax=Proteobacteria RepID...   233   8e-60
UniRef50_D1TF13 Response regulator receiver protein n=1 Tax=Burk...   233   8e-60
UniRef50_A4BIU7 Response regulator containing a CheY-like receiv...   233   9e-60
UniRef50_A7N081 Putative uncharacterized protein n=6 Tax=Vibrio ...   232   1e-59
UniRef50_A3DHG2 Diguanylate cyclase with GAF sensor n=3 Tax=Clos...   232   1e-59
UniRef50_A8UY29 Putative uncharacterized protein n=1 Tax=Hydroge...   232   1e-59
UniRef50_Q5NP17 Diguanylate cyclase with beta propeller sensor n...   232   1e-59
UniRef50_Q1MZ89 Response regulator containing a CheY-like receiv...   232   2e-59
UniRef50_Q1ZGY5 GGDEF domain protein n=1 Tax=Psychromonas sp. CN...   231   2e-59
UniRef50_A4BG19 GGDEF domain protein n=1 Tax=Reinekea blandensis...   231   2e-59
UniRef50_A9FZW1 FHA domain protein n=1 Tax=Sorangium cellulosum ...   231   2e-59
UniRef50_A4C957 Putative uncharacterized protein n=1 Tax=Pseudoa...   231   2e-59
UniRef50_Q07MN8 Diguanylate cyclase n=10 Tax=Bradyrhizobiaceae R...   231   2e-59
UniRef50_A3Y5H4 Diguanylate cyclase (GGDEF domain) n=1 Tax=Marin...   231   2e-59
UniRef50_Q31IP8 Diguanylate cyclase (GGDEF domain) with PAS/PAC ...   231   2e-59
UniRef50_Q1JXK3 Diguanylate cyclase n=1 Tax=Desulfuromonas aceto...   231   2e-59
UniRef50_Q47C76 PAS:GGDEF n=1 Tax=Dechloromonas aromatica RCB Re...   231   2e-59
UniRef50_B5JSY0 Response regulator PleD n=1 Tax=gamma proteobact...   231   2e-59
UniRef50_A0KXZ1 Diguanylate cyclase n=4 Tax=Shewanella RepID=A0K...   231   2e-59
UniRef50_Q486E7 Sensory box/GGDEF domain protein n=2 Tax=Proteob...   231   3e-59
UniRef50_A8UUF5 Diguanylate cyclase (GGDEF domain) n=1 Tax=Hydro...   231   3e-59
UniRef50_B3PIC1 Sensory box/GGDEF family protein n=5 Tax=Gammapr...   231   3e-59
UniRef50_C9QDN5 Putative uncharacterized protein n=1 Tax=Vibrio ...   230   4e-59
UniRef50_A1VA66 Diguanylate cyclase with PAS/PAC sensor n=3 Tax=...   230   4e-59
UniRef50_Q6ALC0 Putative uncharacterized protein n=1 Tax=Desulfo...   230   5e-59
UniRef50_A6Q2P1 Putative uncharacterized protein n=1 Tax=Nitrati...   230   5e-59
UniRef50_A0L4D8 Diguanylate cyclase n=2 Tax=cellular organisms R...   230   5e-59
UniRef50_A8UT68 Putative uncharacterized protein n=2 Tax=Aquific...   230   5e-59
UniRef50_A6VWF8 Diguanylate cyclase n=1 Tax=Marinomonas sp. MWYL...   230   5e-59
UniRef50_A3J836 Putative diguanylate cyclase (GGDEF domain) n=1 ...   230   6e-59
UniRef50_Q30SY9 Diguanylate cyclase (GGDEF domain) n=1 Tax=Sulfu...   230   6e-59
UniRef50_C5T1B3 Diguanylate cyclase n=1 Tax=Acidovorax delafield...   230   6e-59
UniRef50_Q74AN9 Response regulator n=1 Tax=Geobacter sulfurreduc...   230   6e-59
UniRef50_Q2RLY1 Diguanylate cyclase (GGDEF domain) n=1 Tax=Moore...   229   6e-59
UniRef50_A0L7F5 Cyclic nucleotide-binding protein n=1 Tax=Magnet...   229   6e-59
UniRef50_A1SVZ1 Diguanylate cyclase n=1 Tax=Psychromonas ingraha...   229   7e-59
UniRef50_Q2BQN9 Diguanylate cyclase, putative n=1 Tax=Neptuniiba...   229   7e-59
UniRef50_C5BK03 Ggdef domain protein n=1 Tax=Teredinibacter turn...   229   7e-59
UniRef50_A5V1I0 Diguanylate cyclase with GAF sensor n=2 Tax=Rose...   229   7e-59
UniRef50_A1VD57 Diguanylate cyclase n=3 Tax=Desulfovibrio vulgar...   229   7e-59
UniRef50_C7R6Y0 Diguanylate cyclase n=1 Tax=Kangiella koreensis ...   229   7e-59
UniRef50_C8X007 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   229   8e-59
UniRef50_A0LAY9 Diguanylate cyclase n=1 Tax=Magnetococcus sp. MC...   229   8e-59
UniRef50_Q3A5K1 Two component signal transduction response regul...   229   8e-59
UniRef50_B6ER50 Putative GGDEF protein n=1 Tax=Aliivibrio salmon...   229   8e-59
UniRef50_Q2BLA2 Putative uncharacterized protein n=1 Tax=Neptuni...   229   8e-59
UniRef50_C0QBK1 GGDEF domain family protein n=1 Tax=Desulfobacte...   229   8e-59
UniRef50_Q6AJ00 Putative uncharacterized protein n=1 Tax=Desulfo...   229   9e-59
UniRef50_Q88RK0 GGDEF domain protein n=3 Tax=Pseudomonas putida ...   229   9e-59
UniRef50_C9YC42 Putative uncharacterized protein n=1 Tax=Curviba...   229   1e-58
UniRef50_Q7MRL2 Putative uncharacterized protein n=1 Tax=Wolinel...   229   1e-58
UniRef50_B1KMS8 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   229   1e-58
UniRef50_Q3AFS2 GGDEF domain protein n=1 Tax=Carboxydothermus hy...   229   1e-58
UniRef50_UPI000185121C diguanylate cyclase n=1 Tax=Bacillus coah...   229   1e-58
UniRef50_C6P3N4 Diguanylate cyclase n=1 Tax=Sideroxydans lithotr...   228   1e-58
UniRef50_B8DJ36 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   228   2e-58
UniRef50_Q02P32 Putative two-component response regulator n=6 Ta...   228   2e-58
UniRef50_Q7NZV8 Putative uncharacterized protein n=1 Tax=Chromob...   228   2e-58
UniRef50_Q0BZW4 Response regulator PleD n=1 Tax=Hyphomonas neptu...   228   3e-58
UniRef50_Q8DCJ9 FOG: GGDEF domain n=3 Tax=Vibrio RepID=Q8DCJ9_VIBVU   228   3e-58
UniRef50_Q315M6 Diguanylate cyclase n=1 Tax=Desulfovibrio desulf...   228   3e-58
UniRef50_C6P6Y5 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   228   3e-58
UniRef50_C0QPI4 Response regulator n=1 Tax=Persephonella marina ...   227   3e-58
UniRef50_Q2BP61 GGDEF/HAMP domain protein n=1 Tax=Neptuniibacter...   227   3e-58
UniRef50_Q4ZZT3 GGDEF n=5 Tax=Pseudomonas syringae group RepID=Q...   227   3e-58
UniRef50_B7VQN9 GGDEF family protein n=1 Tax=Vibrio splendidus L...   227   4e-58
UniRef50_C6DCR6 Diguanylate cyclase n=6 Tax=Pectobacterium RepID...   227   4e-58
UniRef50_A5UZW7 Diguanylate cyclase with GAF sensor n=2 Tax=Rose...   227   5e-58
UniRef50_Q314F9 Diguanylate cyclase (GGDEF domain) n=1 Tax=Desul...   227   5e-58
UniRef50_Q47Y21 GGDEF domain protein n=1 Tax=Colwellia psychrery...   226   5e-58
UniRef50_Q1D632 GAF domain/GGDEF domain protein n=2 Tax=Cystobac...   226   6e-58
UniRef50_C4XKN6 Putative signaling protein n=2 Tax=Desulfovibrio...   226   6e-58
UniRef50_D0LHJ8 Diguanylate cyclase n=1 Tax=Haliangium ochraceum...   226   6e-58
UniRef50_Q1J2W1 Diguanylate cyclase, GAF, HAMP domains protein n...   226   7e-58
UniRef50_B9TNG7 Putative uncharacterized protein n=1 Tax=Ricinus...   226   7e-58
UniRef50_Q089K4 Diguanylate cyclase n=1 Tax=Shewanella frigidima...   226   7e-58
UniRef50_C4KD29 Response regulator receiver modulated diguanylat...   226   7e-58
UniRef50_A7BV03 Sensor protein n=2 Tax=Beggiatoa sp. PS RepID=A7...   226   8e-58
UniRef50_A6Q525 Signal transduction response regulator n=1 Tax=N...   226   8e-58
UniRef50_Q1K485 Diguanylate cyclase n=1 Tax=Desulfuromonas aceto...   226   9e-58
UniRef50_Q2LS38 Response regulator protein with GGDEF domain n=2...   226   9e-58
UniRef50_Q1K453 Diguanylate cyclase n=1 Tax=Desulfuromonas aceto...   226   9e-58
UniRef50_Q2BML0 Putative diguanylate cyclase (GGDEF domain) n=1 ...   226   1e-57
UniRef50_B8KV43 Sensory box histidine kinase n=1 Tax=gamma prote...   226   1e-57
UniRef50_C1D6I3 Diguanylate cyclase n=1 Tax=Laribacter hongkonge...   225   1e-57
UniRef50_Q2IXE2 Response regulator receiver modulated diguanylat...   225   1e-57
UniRef50_B7WUF6 Diguanylate cyclase n=1 Tax=Comamonas testostero...   225   1e-57
UniRef50_B6ESF0 Membrane associated GGDEF protein n=1 Tax=Aliivi...   225   1e-57
UniRef50_Q1DC46 FHA domain/GGDEF domain protein n=2 Tax=Myxococc...   225   2e-57
UniRef50_UPI0000E11028 response regulator receiver modulated dig...   225   2e-57
UniRef50_B0TJ24 Periplasmic/7TM domain sensor diguanylate cyclas...   225   2e-57
UniRef50_B9QV28 GGDEF domain protein n=1 Tax=Labrenzia alexandri...   225   2e-57
UniRef50_A9WGU1 Diguanylate cyclase n=3 Tax=Chloroflexus RepID=A...   225   2e-57
UniRef50_D1U463 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   224   2e-57
UniRef50_A6VUN1 Diguanylate cyclase n=1 Tax=Marinomonas sp. MWYL...   224   2e-57
UniRef50_B6BII0 GGDEF domain/pas/pac sensor domain protein n=1 T...   224   3e-57
UniRef50_A6LYL1 Diguanylate cyclase n=1 Tax=Clostridium beijerin...   224   3e-57
UniRef50_C6CQG0 Diguanylate cyclase n=7 Tax=Enterobacteriaceae R...   224   3e-57
UniRef50_Q1JXC4 Diguanylate cyclase n=1 Tax=Desulfuromonas aceto...   224   3e-57
UniRef50_A6CY69 Putative GGDEF family protein n=1 Tax=Vibrio shi...   224   4e-57
UniRef50_B8JB86 Diguanylate cyclase n=4 Tax=Anaeromyxobacter Rep...   224   4e-57
UniRef50_C1TNZ5 Diguanylate cyclase (GGDEF) domain-containing pr...   224   4e-57
UniRef50_A1RG31 Diguanylate cyclase n=3 Tax=Shewanella RepID=A1R...   223   5e-57

Sequences not found previously or not previously below threshold:

UniRef50_C6WYA7 Diguanylate cyclase with PAS/PAC and GAF sensors...   240   4e-62
UniRef50_B4U6Y8 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   240   4e-62
UniRef50_B3E6Y7 Diguanylate cyclase n=1 Tax=Geobacter lovleyi SZ...   237   3e-61
UniRef50_B8DLV9 Diguanylate cyclase n=4 Tax=Desulfovibrio vulgar...   237   4e-61
UniRef50_B5JW02 Diguanylate cyclase n=1 Tax=gamma proteobacteriu...   234   3e-60
UniRef50_A9WIR5 Diguanylate cyclase n=3 Tax=Chloroflexus RepID=A...   234   4e-60
UniRef50_Q21PN7 GGDEF domain n=1 Tax=Saccharophagus degradans 2-...   233   5e-60
UniRef50_A1AK55 Diguanylate cyclase with PAS/PAC sensor n=2 Tax=...   233   6e-60
UniRef50_Q30QX5 Diguanylate cyclase n=2 Tax=Proteobacteria RepID...   233   6e-60
UniRef50_C4XPG9 GGDEF domain protein n=1 Tax=Desulfovibrio magne...   233   8e-60
UniRef50_A8TM57 Putative diguanylate cyclase (GGDEF domain) with...   233   8e-60
UniRef50_Q30WV4 Diguanylate cyclase (GGDEF domain) with PAS/PAC ...   233   9e-60
UniRef50_Q0EXC8 Signal transduction protein containing a membran...   233   9e-60
UniRef50_B8DIJ3 Diguanylate cyclase with PAS/PAC and GAF sensors...   232   1e-59
UniRef50_C5T8F5 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   232   1e-59
UniRef50_C6NZP2 Periplasmic/7TM domain sensor diguanylate cyclas...   232   1e-59
UniRef50_Q2VYV6 FOG: GGDEF domain n=2 Tax=Magnetospirillum RepID...   231   2e-59
UniRef50_B9ZM04 Diguanylate cyclase n=1 Tax=Thioalkalivibrio sp....   231   2e-59
UniRef50_B7K273 Response regulator receiver modulated diguanylat...   231   3e-59
UniRef50_C6BZS4 Diguanylate cyclase with PAS/PAC and GAF sensors...   231   3e-59
UniRef50_C8WZ84 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   231   3e-59
UniRef50_UPI0000384142 COG2199: FOG: GGDEF domain n=1 Tax=Magnet...   230   4e-59
UniRef50_Q3ADQ4 Response regulator/sensory box protein/GGDEF dom...   230   4e-59
UniRef50_C1XLF8 Diguanylate cyclase (GGDEF) domain-containing pr...   230   5e-59
UniRef50_Q21HV6 Response regulator receiver modulated diguanylat...   230   5e-59
UniRef50_C5SA57 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   230   5e-59
UniRef50_UPI0001AEC0DE GGDEF domain protein n=1 Tax=Alteromonas ...   230   6e-59
UniRef50_B6BK11 Ggdef/pas/pac-domain containing protein n=1 Tax=...   229   8e-59
UniRef50_B5ZG65 Diguanylate cyclase with PAS/PAC sensor n=4 Tax=...   229   8e-59
UniRef50_Q087A8 Diguanylate cyclase n=1 Tax=Shewanella frigidima...   229   1e-58
UniRef50_B4UA43 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   229   1e-58
UniRef50_Q2W1M0 Response regulator containing a CheY-like receiv...   229   1e-58
UniRef50_A8ZX32 Diguanylate cyclase n=1 Tax=Desulfococcus oleovo...   229   1e-58
UniRef50_C8QVV3 Diguanylate cyclase n=1 Tax=Desulfurivibrio alka...   229   1e-58
UniRef50_C1SIQ7 Diguanylate cyclase (GGDEF) domain-containing pr...   229   1e-58
UniRef50_Q67JR0 Putative uncharacterized protein n=1 Tax=Symbiob...   229   1e-58
UniRef50_B0C2A6 Diguanylate cyclase (GGDEF domain), putative n=3...   228   2e-58
UniRef50_Q3JE99 Response regulator receiver modulated diguanylat...   228   2e-58
UniRef50_Q31EI0 Diguanylate cyclase (GGDEF domain) n=1 Tax=Thiom...   227   3e-58
UniRef50_C0Z6I5 Putative uncharacterized protein n=1 Tax=Breviba...   227   3e-58
UniRef50_Q479Y1 GGDEF n=1 Tax=Dechloromonas aromatica RCB RepID=...   227   4e-58
UniRef50_B7K319 Response regulator receiver modulated diguanylat...   227   5e-58
UniRef50_A0YVG8 GGDEF/response regulator receiver domain protein...   227   5e-58
UniRef50_Q3KAB6 Putative GGDEF domain regulatory protein n=2 Tax...   226   6e-58
UniRef50_A1TWP6 Diguanylate cyclase n=2 Tax=Marinobacter RepID=A...   226   6e-58
UniRef50_A1U7E6 Diguanylate cyclase n=1 Tax=Marinobacter aquaeol...   226   7e-58
UniRef50_B9ZRW3 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   226   8e-58
UniRef50_B7R5U6 PAS fold family protein n=13 Tax=Thermoanaerobac...   226   9e-58
UniRef50_A1U2H0 Diguanylate cyclase n=2 Tax=Marinobacter RepID=A...   226   9e-58
UniRef50_B4U5K2 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   226   9e-58
UniRef50_B9Z0Y0 Diguanylate cyclase n=1 Tax=Lutiella nitroferrum...   226   1e-57
UniRef50_C1TNC9 Diguanylate cyclase (GGDEF) domain-containing pr...   225   1e-57
UniRef50_Q0A8G7 Diguanylate cyclase n=1 Tax=Alkalilimnicola ehrl...   225   1e-57
UniRef50_Q21KC2 GGDEF domain n=1 Tax=Saccharophagus degradans 2-...   225   1e-57
UniRef50_B4RZE8 GGDEF domain protein n=2 Tax=Alteromonadales Rep...   225   1e-57
UniRef50_B0C0K6 Diguanylate cyclase (GGDEF) domain protein n=3 T...   225   1e-57
UniRef50_A8UY33 Putative uncharacterized protein n=1 Tax=Hydroge...   225   2e-57
UniRef50_Q31GI5 Diguanylate cyclase (GGDEF domain) n=1 Tax=Thiom...   225   2e-57
UniRef50_D2L986 Diguanylate cyclase n=1 Tax=Desulfovibrio sp. FW...   225   2e-57
UniRef50_Q2W7A4 Response regulator n=4 Tax=Proteobacteria RepID=...   224   2e-57
UniRef50_B8KJJ5 GGDEF domain protein n=2 Tax=unclassified Gammap...   224   2e-57
UniRef50_C9NRL0 Putative virulence-mediating protein VirC n=2 Ta...   224   2e-57
UniRef50_A9B3D1 Diguanylate cyclase n=2 Tax=Bacteria RepID=A9B3D...   224   2e-57
UniRef50_Q21NS3 Diguanylate cyclase n=5 Tax=Alteromonadales RepI...   224   3e-57
UniRef50_A3WMD3 Phytochrome sensor diguanylate cyclase/phosphodi...   224   3e-57
UniRef50_A4VQF4 GGDEF domain protein n=3 Tax=Proteobacteria RepI...   224   3e-57
UniRef50_C0QLY1 Two domain sensory box histidine kinase (PAS/PAC...   224   3e-57
UniRef50_B7IH39 Diguanylate cyclase n=2 Tax=Bacteria RepID=B7IH3...   224   3e-57
UniRef50_C6NZM9 Diguanylate cyclase n=1 Tax=Sideroxydans lithotr...   224   4e-57
UniRef50_C5T761 Diguanylate cyclase n=1 Tax=Acidovorax delafield...   224   4e-57
UniRef50_A1U4U5 Diguanylate cyclase n=2 Tax=Marinobacter RepID=A...   224   4e-57
UniRef50_B3QU32 Diguanylate cyclase and serine/threonine protein...   223   4e-57
UniRef50_A1SRM4 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   223   4e-57
UniRef50_Q2BQL8 Probable two-component response regulator n=1 Ta...   223   4e-57
UniRef50_A9L0C9 Diguanylate cyclase n=2 Tax=Shewanella baltica R...   223   5e-57
UniRef50_A0YVN1 PleD-like protein n=2 Tax=Cyanobacteria RepID=A0...   223   5e-57

>UniRef50_Q8XAZ4 Uncharacterized protein yneF n=65 Tax=Enterobacteriaceae
           RepID=YNEF_ECO57
          Length = 315

 Score =  471 bits (1214), Expect = e-131,   Method: Composition-based stats.
 Identities = 314/315 (99%), Positives = 314/315 (99%)

Query: 1   MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA 60
           MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA
Sbjct: 1   MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA 60

Query: 61  FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT 120
           FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT
Sbjct: 61  FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT 120

Query: 121 MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL 180
           MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL
Sbjct: 121 MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL 180

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL
Sbjct: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASY TLTDDFNKLMVEADTCLYRSKKD
Sbjct: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKD 300

Query: 301 GRNRTSTMRYGEEVV 315
           GRNRTSTMRYGEEVV
Sbjct: 301 GRNRTSTMRYGEEVV 315


>UniRef50_D2TIF8 Putative signal transduction protein n=2 Tax=Enterobacteriaceae
           RepID=D2TIF8_CITRO
          Length = 484

 Score =  421 bits (1083), Expect = e-116,   Method: Composition-based stats.
 Identities = 245/307 (79%), Positives = 276/307 (89%)

Query: 1   MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA 60
           + ADWFSEQFSTGVLIVPCMLTL IPG + RF+ EQMMP IALIVSV+ASVVIGGAGSLA
Sbjct: 163 LFADWFSEQFSTGVLIVPCMLTLGIPGSVKRFRPEQMMPVIALIVSVLASVVIGGAGSLA 222

Query: 61  FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT 120
           FPLPALIWCAVRYTPQVTCLLTF+TGAVEIVLVANSVI+I+V SP S PQMFSARLGI T
Sbjct: 223 FPLPALIWCAVRYTPQVTCLLTFLTGAVEIVLVANSVINIAVASPLSAPQMFSARLGIVT 282

Query: 121 MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL 180
           MAICPIMV+FSVAAINSLMKQ++LRADFDFLTQVYSRSGLYEALK  +   +Q++TVMLL
Sbjct: 283 MAICPIMVAFSVAAINSLMKQISLRADFDFLTQVYSRSGLYEALKRQAYPASQNMTVMLL 342

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DIDYFKSINDNYGHECGD+VL VFARHIQ+IVGD+GLVARMGGEEFAV +P+ +P +G+ 
Sbjct: 343 DIDYFKSINDNYGHECGDRVLCVFARHIQRIVGDRGLVARMGGEEFAVVLPTSHPEEGMQ 402

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           +AE IRK V LQPF WQQ+++YLTVSIGVG+G+ +  T+TD FNKLMVEAD CLYRSK +
Sbjct: 403 LAETIRKAVALQPFDWQQQSIYLTVSIGVGNGKIAAQTVTDIFNKLMVEADECLYRSKNE 462

Query: 301 GRNRTST 307
           GRNRTS 
Sbjct: 463 GRNRTSA 469


>UniRef50_A8A075 Diguanylate cyclase (GGDEF) domain protein n=2
           Tax=Enterobacteriaceae RepID=A8A075_ECOHS
          Length = 279

 Score =  414 bits (1065), Expect = e-114,   Method: Composition-based stats.
 Identities = 278/279 (99%), Positives = 278/279 (99%)

Query: 37  MMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANS 96
           MMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANS
Sbjct: 1   MMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANS 60

Query: 97  VIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYS 156
           VIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYS
Sbjct: 61  VIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYS 120

Query: 157 RSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKG 216
           RSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKG
Sbjct: 121 RSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKG 180

Query: 217 LVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASY 276
           LVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASY
Sbjct: 181 LVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASY 240

Query: 277 LTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV 315
            TLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
Sbjct: 241 RTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV 279


>UniRef50_B1JAS6 Diguanylate cyclase n=5 Tax=Pseudomonas RepID=B1JAS6_PSEPW
          Length = 469

 Score =  316 bits (810), Expect = 7e-85,   Method: Composition-based stats.
 Identities = 119/319 (37%), Positives = 176/319 (55%), Gaps = 10/319 (3%)

Query: 5   WFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIA--SVVIGGAGSLAFP 62
           WFSEQFST VL++P +LT      L R  A+ +  A  L++      S+  GG G++AFP
Sbjct: 153 WFSEQFSTAVLLLPVLLTAPSARALVRSGAQAVALAPLLVLLASLAFSIAFGGPGAIAFP 212

Query: 63  LPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISV-GSPFSIPQMFSARLGIATM 121
           + AL+WCA  Y+P +  LLT + G+  IV VA +++  SV  S   +  + SAR+GIA +
Sbjct: 213 IAALLWCAWTYSPFLVSLLTLIAGSTLIVAVAQNLMHFSVPQSELGVTTLMSARMGIAML 272

Query: 122 AICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH-----LT 176
            + P++V+    A  SL+ ++A +A  D LT   +RS       +    + +H     LT
Sbjct: 273 ILGPLVVACVSQANRSLLARLAHQATIDHLTGALTRSAFTRRANALLDSRQKHAQALPLT 332

Query: 177 VMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPV 236
           +M+LDID+FKSIND +GH  GD+VL  FAR +Q  +    L+ARMGGEEF V +P + P 
Sbjct: 333 LMMLDIDHFKSINDRHGHGVGDQVLRQFARTLQDQLHGGELLARMGGEEFVVLLPGLAPE 392

Query: 237 DGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYR 296
                AE++R+ V+            +TVSIG+          T   ++L+  AD  LYR
Sbjct: 393 RASFTAERLRRAVQDLHLAKGDGRPQITVSIGLDGCAGHEPAPT--LDELLARADQALYR 450

Query: 297 SKKDGRNRTSTMRYGEEVV 315
           +K  GRNR        +V+
Sbjct: 451 AKAHGRNRVEVAETQRQVI 469


>UniRef50_C8QCH2 Diguanylate cyclase n=1 Tax=Pantoea sp. At-9b RepID=C8QCH2_9ENTR
          Length = 474

 Score =  313 bits (804), Expect = 4e-84,   Method: Composition-based stats.
 Identities = 132/308 (42%), Positives = 195/308 (63%), Gaps = 4/308 (1%)

Query: 3   ADWFSEQFSTGVLIVPCMLTLAIPGVLPR--FKAEQMMPAIALIVSVIASVVIGGAGSLA 60
            DWFSEQFST ++++P +L   +  VL R      +++P   +++S+    +IGGAGSL 
Sbjct: 154 GDWFSEQFSTSLMLLPVLLARPLRTVLWRSLLHPGKLLPLTGVVLSLTIGAMIGGAGSLT 213

Query: 61  FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDIS-VGSPFSIPQMFSARLGIA 119
           FP+PALIWCA+     +T L+  +TG  EI+LV++ V++I    +   I  + S RLG+A
Sbjct: 214 FPVPALIWCAIVLPIPITSLVLLITGITEIILVSHGVMNIQGDDALLPISHLTSVRLGVA 273

Query: 120 TMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVML 179
           T+ I P++V+ S+ AI  L ++++LRA+FDFLTQ+ SRSGLYE L+       +   V++
Sbjct: 274 TITISPLLVAVSMDAIRQLNQRLSLRANFDFLTQLLSRSGLYENLRQEPFSPQRAAGVVM 333

Query: 180 LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGL 239
           LD+DYFK+INDN+GH+ GD VL   AR IQ +V ++GLV R GGEEF V V   N     
Sbjct: 334 LDVDYFKTINDNFGHDAGDGVLEEIARRIQDVVNNRGLVCRFGGEEFVVVVFDYNHSQLY 393

Query: 240 LMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRA-SYLTLTDDFNKLMVEADTCLYRSK 298
            +AE IR+ +  + F  Q  T+ +T S+G+  G A +        N+L+  AD  LY SK
Sbjct: 394 QLAEVIRQSMVREKFWLQGNTVTVTASLGLALGNAVNEREWQGVVNRLISAADKNLYLSK 453

Query: 299 KDGRNRTS 306
           ++GRN+TS
Sbjct: 454 RNGRNQTS 461


>UniRef50_C6CDM3 Diguanylate cyclase n=1 Tax=Dickeya dadantii Ech703
           RepID=C6CDM3_DICDC
          Length = 469

 Score =  302 bits (774), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 109/310 (35%), Positives = 178/310 (57%), Gaps = 6/310 (1%)

Query: 2   LADWFSEQFSTGVLIVPCMLTL--AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSL 59
             +WFS+QF T VL +P +LT+   I   +P      ++P + L  S+I   +I     L
Sbjct: 158 FLNWFSDQFYTSVLFLPLLLTVRSNIRLRIPALNFNDILPILFLAASLIVGAMISPLAIL 217

Query: 60  AFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSI-PQMFSARLGI 118
           AFPLPAL WCA+ Y   +T L+T  TG +++++ A  V  I  G       Q+   R+ I
Sbjct: 218 AFPLPALTWCAIVYPLWLTRLITLCTGTLQLIVSAEHVYAIYSGLHDEFTNQVVITRISI 277

Query: 119 ATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQT-QHLTV 177
           A +   P+ ++ +   I  L K++ L+A +DFLT   SR G  EAL +   ++  ++++V
Sbjct: 278 AAIIFSPLFMAMNAKTIRLLNKRLLLQASYDFLTNTLSRYGFNEALTNYGKEERYRNVSV 337

Query: 178 --MLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNP 235
             ML+DID+FK IND++GH+CGD+VL   A  I+  + ++GL++R+GGEEFAV     +P
Sbjct: 338 NIMLIDIDHFKHINDSFGHDCGDEVLKQVAAIIKDTINEQGLISRIGGEEFAVVCFDYSP 397

Query: 236 VDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLY 295
                +A+K+R+ +    F + Q  + + +SIG+    +    L +  ++L  +AD  LY
Sbjct: 398 DAFYWLADKLRRRIYETTFMFNQSPVPVAISIGLAHASSPNGDLLNTVHQLCTQADKNLY 457

Query: 296 RSKKDGRNRT 305
            +K+ GRN+T
Sbjct: 458 AAKRQGRNQT 467


>UniRef50_D0IXN6 Diguanylate cyclase n=2 Tax=Comamonas testosteroni
           RepID=D0IXN6_COMTE
          Length = 473

 Score =  299 bits (766), Expect = 1e-79,   Method: Composition-based stats.
 Identities = 92/314 (29%), Positives = 163/314 (51%), Gaps = 13/314 (4%)

Query: 2   LADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAE-----QMMPAIALIVSVIASVVIGGA 56
            + W S ++   ++ +P +L             E     +++P +++I     S  I G 
Sbjct: 162 FSMWLSSEWLNYMMFLPIVLAWPTRKQPVGHLGEPSPLRRILPLLSVIALEAISYWIKGP 221

Query: 57  GSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARL 116
           GSLAF LPALIWCA+ Y      L+T       I+ ++   ++    +P    +  S R+
Sbjct: 222 GSLAFSLPALIWCALSYRIFSLTLITATLCLSSIIFISLGTLEF---TPAHFLETLSFRM 278

Query: 117 GIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQ 173
           G+  + + P+ V+ S  A N LM++++   + DFLT + +R       + +     +  Q
Sbjct: 279 GLCMLVLGPLAVAGSHMARNELMQKLSHAVNHDFLTDMLARGAFMKQGQRILERCRQDGQ 338

Query: 174 HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSV 233
              +++LD+D+FK IND++GH  GD++L  F++ + +++  + +V RMGGEEFAVA+P V
Sbjct: 339 PFAILMLDLDHFKQINDSFGHAGGDQLLRSFSQTLSQVLRAQDIVGRMGGEEFAVALPKV 398

Query: 234 NPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTC 293
           +      +A++I + +         KT+  TVSIG+    +  L      + L+++AD  
Sbjct: 399 DASAAQEIAKRINRAIRELRVPMNDKTMSATVSIGLVHTTS--LQAHQSLDMLLLQADQA 456

Query: 294 LYRSKKDGRNRTST 307
           LY +K  GRNR S+
Sbjct: 457 LYEAKAAGRNRVSS 470


>UniRef50_A0P392 GGDEF domain protein n=1 Tax=Labrenzia aggregata IAM 12614
           RepID=A0P392_9RHOB
          Length = 307

 Score =  297 bits (760), Expect = 4e-79,   Method: Composition-based stats.
 Identities = 102/310 (32%), Positives = 158/310 (50%), Gaps = 13/310 (4%)

Query: 10  FSTGVLIVPCMLTLA--------IPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAF 61
               +  +P +L+           P  + +F  E+  P I L+VS IA  ++GG G++AF
Sbjct: 1   MVNYISFLPVVLSAPKLDGTHTDFPARIRQFWQEKWAPLILLLVSCIAGTLVGGPGAIAF 60

Query: 62  PLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATM 121
           P+PAL+WC + Y    T +LT   G   +V+++N + D S      +  + S RLGI+ +
Sbjct: 61  PVPALLWCGLVYPVFPTTILTLCIGVWGLVILSNGLGD-SASLQLDVMTLVSIRLGISLV 119

Query: 122 AICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLD 181
           A+ PIM+S      N+L+ ++   A  D LT V +R+   E         T    ++++D
Sbjct: 120 ALAPIMLSCVTQNRNALVGRLQYLATHDQLTNVLNRNAFREEAARRLALGTSGFALLMVD 179

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           +D FK++ND +GH  GD VL  F   ++  +    L+ RMGGEEFAV +P    VD +  
Sbjct: 180 LDDFKAVNDTHGHATGDTVLVNFVHRVKNTLPPGSLLGRMGGEEFAVLIPDCRQVDAVAE 239

Query: 242 AEKIRKGVELQPFT-WQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           AE IR+ V  +P      K + +T S+GV    A      D  + L+ EAD   Y +KK 
Sbjct: 240 AENIRQSVGTEPVPAGDGKEVRVTASLGVV---AVEHGDADSLDTLLAEADRLCYLAKKR 296

Query: 301 GRNRTSTMRY 310
           GRNR   +  
Sbjct: 297 GRNRVEAIEE 306


>UniRef50_D0FTB2 Conserved uncharacterized protein YneF n=3 Tax=Erwinia
           RepID=D0FTB2_ERWPY
          Length = 464

 Score =  295 bits (757), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 120/312 (38%), Positives = 184/312 (58%), Gaps = 12/312 (3%)

Query: 3   ADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKA----EQMMPAIALIVSVIASVVIGGAGS 58
           + WFSEQ ST +L++P M++L     LP+  A      ++P + LIV++++++ +GG GS
Sbjct: 150 SSWFSEQMSTSILLLPLMISLPRRQQLPQLAAALRDSSVLPLLTLIVTIVSAIWLGGGGS 209

Query: 59  LAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDIS-VGSPFSIPQMFSARLG 117
           L FPLPAL+WCA+ Y   VTC LT +TG  EI+LVA +V++I   G  F I  + SARLG
Sbjct: 210 LLFPLPALLWCAISYPLFVTCFLTMLTGISEIILVAGNVLNIQGKGDLFRIDSLSSARLG 269

Query: 118 IATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH--- 174
           +A M I P++VS S  +   L+ ++  RAD+DFLT   +RSGL   L S    + +    
Sbjct: 270 VAAMLIGPLIVSLSTLSNKKLVARITRRADYDFLTGALTRSGLSTKLDSLVTGRNRQQGF 329

Query: 175 -LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSV 233
               +++DID FK IND +GH  GD VL+  A  +++ +    LV RMGGEEF + +  +
Sbjct: 330 IGAALVIDIDRFKDINDTWGHAAGDYVLAKTAECLREGLSPSTLVCRMGGEEFLILIQGM 389

Query: 234 NPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTC 293
                 L+A ++R+ VE     +    L +TVSIG+ S     ++  +  ++ ++ AD  
Sbjct: 390 TQPRSSLLANRLRQNVENNKIIFNGHDLSVTVSIGISSLN---ISNVNSLDESIMRADEQ 446

Query: 294 LYRSKKDGRNRT 305
           LY +K  GRN+ 
Sbjct: 447 LYIAKSSGRNQV 458


>UniRef50_C6CM30 Diguanylate cyclase n=1 Tax=Dickeya zeae Ech1591 RepID=C6CM30_DICZE
          Length = 470

 Score =  290 bits (744), Expect = 3e-77,   Method: Composition-based stats.
 Identities = 121/310 (39%), Positives = 182/310 (58%), Gaps = 6/310 (1%)

Query: 2   LADWFSEQFSTGVLIVPCMLTL--AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSL 59
             +WFS+QF T VL +P +LTL   IP  LP  +    +P + L+VS++ + ++G    L
Sbjct: 159 FLNWFSDQFYTAVLFLPLLLTLRSQIPLQLPMLRLSDALPLLLLLVSIVVAPLLGPVAIL 218

Query: 60  AFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDI-SVGSPFSIPQMFSARLGI 118
           AFPLPAL WCA+ Y   +  L+T   GA E++L A  V    S   P+ + Q+  AR+GI
Sbjct: 219 AFPLPALTWCAIVYPLWLIRLITLCVGATELILTAEHVYAFYSPQDPYFMHQIIIARIGI 278

Query: 119 ATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHL 175
           A     P+M++ +   I  L  ++  +A  DFLT   SR G  EAL         Q   +
Sbjct: 279 AATIFSPLMMATNARTIRQLNARLLQQASHDFLTNTLSRYGFTEALTTHGQSVKSQHDAV 338

Query: 176 TVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNP 235
            +ML+DID+FK+IND++GH+CGD++L   A+ IQ+ V  +GLV+R+GGEEFAV   + NP
Sbjct: 339 NIMLIDIDHFKNINDSFGHDCGDEILRQVAKVIQQAVSAQGLVSRIGGEEFAVVCFNYNP 398

Query: 236 VDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLY 295
                +A+ +R+ ++   F + Q+ + +TVSIG+     S   L D  ++L   AD  LY
Sbjct: 399 SAFYRLADSLRQTIQQTVFLFNQQPVPVTVSIGIAHAPTSGKYLVDTVHELFPLADKNLY 458

Query: 296 RSKKDGRNRT 305
            +K++GRNRT
Sbjct: 459 TAKREGRNRT 468


>UniRef50_D2C311 Diguanylate cyclase n=1 Tax=Dickeya dadantii Ech586
           RepID=D2C311_DICD5
          Length = 471

 Score =  288 bits (737), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 116/311 (37%), Positives = 180/311 (57%), Gaps = 7/311 (2%)

Query: 2   LADWFSEQFSTGVLIVPCMLTLA--IPGVLPR-FKAEQMMPAIALIVSVIASVVIGGAGS 58
             +WFS+QF T VL +P +LTL   IP  LP   +    +P + L++S+  + ++G    
Sbjct: 159 FLNWFSDQFYTAVLFLPLLLTLQSRIPLHLPASLQMADALPLLLLLLSICIAPLLGPVAI 218

Query: 59  LAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDIS-VGSPFSIPQMFSARLG 117
           LAFPLPAL WCA+ Y   +  L+T   GA E+++ A  V  +     P  + Q+  AR+G
Sbjct: 219 LAFPLPALTWCAIVYPLWLIRLITLCVGATELIMTAEHVYALYNPQDPMFLHQVVIARIG 278

Query: 118 IATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEAL---KSPSLKQTQH 174
           IA     P+M++ +   I  L  ++  +A  DFLT   SR G  EAL         Q   
Sbjct: 279 IAATIFSPLMMATNARTIRQLNARLLRQASHDFLTNTLSRYGFTEALSTHDQNIKSQQDA 338

Query: 175 LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVN 234
           + +ML+DID FK+IND++GH+CGD++L   A  IQ+ V  +GLV+R+GGEEFAV   + +
Sbjct: 339 VNIMLIDIDNFKNINDSFGHDCGDEILRQVANVIQRTVSAQGLVSRIGGEEFAVVCFNYS 398

Query: 235 PVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCL 294
           P     +A+++R+ ++   F + Q+ + +TVSIG+   + +   L D  ++L   AD  L
Sbjct: 399 PPAFYRLADELRQTIQHTVFLFNQQHVPVTVSIGIAHAQVAGKHLVDTVHELFPLADKNL 458

Query: 295 YRSKKDGRNRT 305
           Y +K++GRNRT
Sbjct: 459 YTAKREGRNRT 469


>UniRef50_A8GAZ5 Diguanylate cyclase n=2 Tax=Serratia RepID=A8GAZ5_SERP5
          Length = 482

 Score =  287 bits (734), Expect = 5e-76,   Method: Composition-based stats.
 Identities = 116/315 (36%), Positives = 181/315 (57%), Gaps = 13/315 (4%)

Query: 5   WFSEQFSTGVLIVPCMLTLAIPGVLPR----FKAEQMMPAIALIVSVIASVVIGGAGSLA 60
           WFSEQFST +L++P +L       L R    ++    MP +AL+ S++ SV IGG G++A
Sbjct: 158 WFSEQFSTNLLLLPVLLAAPRLKQLLRMQINWQLRASMPLLALLFSLVFSVYIGGPGAIA 217

Query: 61  FPLPALIWCAVRYTPQVTCLLTFVTGAVEIV-LVANSVIDISVGSPFSI-PQMFSARLGI 118
           FP+PAL+WCAVRY      LLT +TG  EI  + AN ++  +  +  +    + SARLGI
Sbjct: 218 FPIPALLWCAVRYQLFTVTLLTLLTGMTEISSISANLMLYETPNNHIAFLDTLMSARLGI 277

Query: 119 ATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEA---LKSPSLKQTQHL 175
           A + + P++++ S+A    L++++   A+ DFLT V +R+ L      L     K  + +
Sbjct: 278 AMLVMGPLILASSIAVNRKLLRRLEHSANHDFLTGVLARNALTRKAGELLEHKHKSKEAV 337

Query: 176 TVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNP 235
           +++L+DID+FK IND +GH  GD+VL+ FA  +++ +    L  R+GGEEFA+ +P    
Sbjct: 338 SLLLIDIDHFKQINDTHGHLVGDQVLASFAHIVRRELRHDQLFGRLGGEEFAIMLPRALA 397

Query: 236 VDGLLMAEKIRKGVELQPFTWQQK-TLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCL 294
             G+ +AE +R+ V+        K  L +T+S+GV S     +       +LM  AD  L
Sbjct: 398 AQGVALAEHLRQLVQKADLLPTGKVPLNITISVGVASL---GMNEVKSLEQLMNMADIAL 454

Query: 295 YRSKKDGRNRTSTMR 309
           YR+K  GRNR  +  
Sbjct: 455 YRAKSQGRNRVESFN 469


>UniRef50_D0S942 Response regulator n=2 Tax=Acinetobacter RepID=D0S942_ACIJO
          Length = 476

 Score =  280 bits (717), Expect = 5e-74,   Method: Composition-based stats.
 Identities = 85/318 (26%), Positives = 150/318 (47%), Gaps = 23/318 (7%)

Query: 5   WFSEQFSTGVLIVPCMLTLAIPGVLPRF---------KAEQMMPAIALIVSVIASVVIGG 55
           W++ +    + ++P MLT      L            +   ++P +++++SV  + +  G
Sbjct: 167 WWTGEVLNCISLLPLMLTFPAAKKLKYLWNNRRQCETQFVDVLPLLSVLISVACTHLFFG 226

Query: 56  AGSLAFPLPALIWCAVRYTPQVTC----LLTFVTGAVEIVLVANSVIDISVGSPFSIPQM 111
            G+L FPL  LIW A+ Y          L+ FVT         +   D  + +       
Sbjct: 227 PGALLFPLAGLIWAALSYNLFYVSIINSLVCFVTYHSLTTYYISRTADNFLATS------ 280

Query: 112 FSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQ 171
            S R+G+  + I P+++       + L K+V   A+ D LT V +R   +   ++   + 
Sbjct: 281 ISVRIGLCMLMIAPLLLCIVSRNRHDLYKEVLYLANHDPLTHVGNRRFFFTQTENLLKEN 340

Query: 172 -TQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAV 230
             + +++++LDID+FK +ND YGH  GD +L  FA  ++  + ++ L ARMGGEEF V +
Sbjct: 341 LVKSMSIIVLDIDHFKKMNDQYGHYIGDVLLQSFATTVKSNLREQDLFARMGGEEFVVVL 400

Query: 231 PSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEA 290
            +   ++  ++AE+I + V           L +TVS+GV       L   +    L+  A
Sbjct: 401 NNTTEIESQIIAERICRAVATSKTQVAHAVLSMTVSLGVVH---QVLPTQNSLQSLLNRA 457

Query: 291 DTCLYRSKKDGRNRTSTM 308
           D  LY++K  GRN+    
Sbjct: 458 DRALYQAKTLGRNQVQLA 475


>UniRef50_B7GZC2 Uncharacterized protein yneF n=10 Tax=Acinetobacter
           RepID=B7GZC2_ACIB3
          Length = 473

 Score =  270 bits (691), Expect = 4e-71,   Method: Composition-based stats.
 Identities = 95/316 (30%), Positives = 151/316 (47%), Gaps = 17/316 (5%)

Query: 2   LADWFSEQFSTGVLIVPCMLTLAIPGVLPRF--------KAEQMMPAIALIVSVIASVVI 53
              W + +    +L++P +L +     +           KA   +P  A+++S+  S   
Sbjct: 159 FGYWVTSELQNALLLLPIILNIPPYLKIKTHLKGNRIYIKAIDFLPLFAVLISIGVSYYD 218

Query: 54  GGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFS 113
            G GSL +P+ ALIWCA+RY P +  L+T  T A  I  V+   + +      S     S
Sbjct: 219 SGPGSLLYPIAALIWCAIRYKPIIVALITSFTSAYIIYHVSGHYLLLYPQDYLSNN--IS 276

Query: 114 ARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEA---LKSPSLK 170
            R+G+  M + P+ VS   A  + L++++      D LT   +R    ++   L+    K
Sbjct: 277 IRIGLIMMTVAPLTVSSISALHSELIQKLQHAIAHDELTSSLTRRQFLQSVRLLQEKVQK 336

Query: 171 QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAV 230
           + +     +LD+D+FK +ND+YGH  GD+ L      IQ I+    L+ R GGEEFA+ +
Sbjct: 337 ENKTSAFFMLDVDHFKKVNDSYGHLIGDRALQTCVTTIQNILHPHDLLGRFGGEEFAIFI 396

Query: 231 PSVNPVDGLLMAEKIRKGVELQPFTWQQK-TLYLTVSIGVGSGRASYLTLTDDFNKLMVE 289
           P         +AE+IR  +  QP     K  +++ VSIG+     SY         L  E
Sbjct: 397 PDTTREAAFELAERIRIQISQQPIYVYGKLPIFVQVSIGISLYSPSYHR---SIESLFKE 453

Query: 290 ADTCLYRSKKDGRNRT 305
           AD  LY++K+ GRNR 
Sbjct: 454 ADDALYQAKRQGRNRV 469


>UniRef50_A8GES9 Diguanylate cyclase n=2 Tax=Serratia RepID=A8GES9_SERP5
          Length = 500

 Score =  268 bits (687), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 101/325 (31%), Positives = 166/325 (51%), Gaps = 27/325 (8%)

Query: 2   LADWFSEQFSTGVLIVPCMLTLA----------IPGVLPRFKAEQMMPAIALIV----SV 47
           LA W S +F+  + ++P +L                V  R +    +  IA+++    + 
Sbjct: 173 LALWLSSEFTNYITLMPFILAFPRDWKGYLRSIFQAVTLRSQWPNTVRKIAVLLLLLLAC 232

Query: 48  IASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFS 107
             S++IGG G++ FP+P L+W A+ ++     L + +   +  VL  +  ID+ + +   
Sbjct: 233 FGSILIGGPGAVIFPMPILLWLAMSFS-----LFSTMIAVLVYVLWCHLAIDLGLITTNL 287

Query: 108 IPQMF----SARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEA 163
             +M     S RLG+A +A+ PI V+    A N+L++++   A+ D LT V +RS   + 
Sbjct: 288 DMKMLQNTVSMRLGVALLALGPIAVASMNFARNALLQRLEHVANHDALTHVLTRSAFMQR 347

Query: 164 LKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGG 223
                 ++ + + +M+LDIDYFKSIND +GH  GD  L  F R I   + D  L  RMGG
Sbjct: 348 GTRLVSQKGERICIMMLDIDYFKSINDRFGHAGGDAALLSFTRAITGDLRDNDLFGRMGG 407

Query: 224 EEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ-QKTLYLTVSIGVGSGRASYLTLTDD 282
           EEFA+  P     D L +AE++R  VE++         L +TVSIG+ +          +
Sbjct: 408 EEFAIVAPIAQQQDALSLAERLRHRVEIESINMPAGAALQITVSIGMVTCIGG---SGQN 464

Query: 283 FNKLMVEADTCLYRSKKDGRNRTST 307
            + L+  AD  +Y++K  GRNR +T
Sbjct: 465 LDNLLKIADLAVYKAKNSGRNRVAT 489


>UniRef50_C6DKF8 Diguanylate cyclase n=5 Tax=Pectobacterium RepID=C6DKF8_PECCP
          Length = 489

 Score =  268 bits (686), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 94/327 (28%), Positives = 151/327 (46%), Gaps = 18/327 (5%)

Query: 2   LADWFSEQFSTGVLIVPCML-------TLAIPGVLPRFKAEQMMPAIALIVSVIASVVIG 54
             DWFSEQ  TG+++    L        L    + P+   E + P +  I+ ++ S+   
Sbjct: 167 FMDWFSEQLGTGIILAFFFLRGKDILRALRNIPLCPKHIRENIFPFLVFIIFLLVSLFFQ 226

Query: 55  GAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVAN--SVIDISVGSPFSIPQMF 112
            A  +   +  L  CA  Y+  +  LL  +TG +   L  N   ++  S    +    + 
Sbjct: 227 DASLITLSVIPLTLCAFNYSFPIMSLLCAITGVILNYLYINQVGILINSNSEAYINSFLT 286

Query: 113 SARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP----S 168
           +ARL IA + +  + VS  V+    L+K +   +  D LT  ++R      L        
Sbjct: 287 TARLNIAMLIMAMLSVSHFVSMNRRLIKIIESNSLKDALTNTFNRRAFLSMLNGRQGLLM 346

Query: 169 LKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAV 228
            K+ + LT++ LDIDYFK +ND YGH  GD++++ FAR +   +    ++ R GGEEF +
Sbjct: 347 NKRKRQLTLLFLDIDYFKQVNDTYGHASGDELIASFARMLSANIRPSDILCRWGGEEFVI 406

Query: 229 AVPSVNPVDGLLMAEKIRKGVELQPFTW-QQKTLYLTVSIGVGSGRASYLTLTDDFNKLM 287
           A   +       MAE +R   E  P      + +  T+SIGV +        T D   L+
Sbjct: 407 AAYDLTAEQSAAMAETLRHLTESTPLVLSDGREIRFTISIGVVTFPQYEGGNTYD---LI 463

Query: 288 VEADTCLYRSKKDGRNRTSTMRYGEEV 314
             AD  LY++K  GRNR   +R  E++
Sbjct: 464 GLADEQLYKAKAQGRNRVC-LRLVEDI 489


>UniRef50_A9C2H0 Diguanylate cyclase n=2 Tax=cellular organisms RepID=A9C2H0_DELAS
          Length = 496

 Score =  268 bits (685), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 91/326 (27%), Positives = 165/326 (50%), Gaps = 20/326 (6%)

Query: 1   MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMP--------AIALIVSVIASVV 52
           M+A WFS +    + ++  +L      + P     Q            +AL +S   ++ 
Sbjct: 160 MMAMWFSSELM-HMTLLLPVLLSLPAKLEPLSWRSQPFKQTAQALLPLLALAISESIAIY 218

Query: 53  IGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMF 112
           +GG G+L+  +PA++ CA+RY   V  LL  V+ A+++    + V+  S G+   +   F
Sbjct: 219 LGGPGALSLTMPAMLLCAMRYRLFVVALLNLVSCAIKL-ATFSHVLFSSPGTE--LETTF 275

Query: 113 SARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKS---PSL 169
           S RLG+A ++I P+ V+ ++ A   ++ ++    + D LT + +R+   E  +       
Sbjct: 276 SFRLGLAMLSIGPLAVACTLMAFKDMLSKLRHAVNHDALTGLLARTSFLERAQRTLERLQ 335

Query: 170 KQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVA 229
           ++ Q   +++LD+D+FK IND +GH  GD+VL   +  + + +    L+ R+GGEEFAV 
Sbjct: 336 RERQSGAMLMLDLDHFKHINDRHGHAAGDRVLQEVSARLSQALRPHELIGRLGGEEFAVL 395

Query: 230 VPSVNPVDGLLMAEKIRKGVELQPFTWQQK-TLYLTVSIGVGSGRASYLTLTDDFNKLMV 288
           +P  + V    +A+++ +              +  T+SIG+G    +Y  L    + L+ 
Sbjct: 396 LPGADCVTARAVAQRLCEATREIRIDMNDGAAICPTLSIGIGCTNMAYPPLG--LSALLR 453

Query: 289 EADTCLYRSKKDGRNR--TSTMRYGE 312
            ADT LY++K  GR+R   +  R GE
Sbjct: 454 MADTALYQAKASGRDRYFVAGERPGE 479


>UniRef50_C6RK39 Diguanylate cyclase n=2 Tax=Acinetobacter radioresistens
           RepID=C6RK39_ACIRA
          Length = 445

 Score =  267 bits (684), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 89/319 (27%), Positives = 155/319 (48%), Gaps = 17/319 (5%)

Query: 1   MLADWFSEQFSTGVLIVPCMLTLAIPGVLPR--------FKAEQMMPAIALIVSVIASVV 52
           +   WFS +    +LI+P +L L     + +        +    ++P   L+ S+  S  
Sbjct: 130 IFGYWFSAELQNAILILPLILNLPYQKGIHQIFRPADGPYSFLHILPIFVLLFSLSLSYY 189

Query: 53  IGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMF 112
             G G++ +P+ ALIWCA+ Y      L+T ++       +++  + +     +   +M 
Sbjct: 190 DSGPGAILYPIAALIWCALNYRHFTVALITSISCFYIAFFMSDKYLTLYPEQYYL--EMI 247

Query: 113 SARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEA---LKSPSL 169
           S R GI TMAI P+ VS      + L++++      D LT   +R     +   L     
Sbjct: 248 SLRFGIITMAIAPLTVSSINRIRSQLIRELQHHVAHDELTASLTRRQFMRSAHLLLRQRT 307

Query: 170 KQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVA 229
           +++Q L V++LDID+FK IND YGH+ GD+ L   A  I++ +    L  R+GGEEFA+ 
Sbjct: 308 QESQSLAVLMLDIDHFKLINDKYGHQAGDEALRACAAVIRRSLRGYDLFGRLGGEEFAIV 367

Query: 230 VPSVNPVDGLLMAEKIRKGVELQPFTWQQKT-LYLTVSIGVGSGRASYLTLTDDFNKLMV 288
           +  V P +   +AE+IR+ ++        +T   + +SIG+     +      +   L+ 
Sbjct: 368 LLDVGPAEAFEIAERIRETLKTHIIQLDAETQFSIRISIGLTLFNPAVPH---NIEALLH 424

Query: 289 EADTCLYRSKKDGRNRTST 307
           +AD  LY +K+ GR+R   
Sbjct: 425 KADLALYEAKRSGRDRVVI 443


>UniRef50_C3JIZ7 Diguanylate cyclase n=2 Tax=Rhodococcus erythropolis
           RepID=C3JIZ7_RHOER
          Length = 471

 Score =  263 bits (674), Expect = 4e-69,   Method: Composition-based stats.
 Identities = 100/321 (31%), Positives = 150/321 (46%), Gaps = 20/321 (6%)

Query: 5   WFSEQFSTGVLIVPCMLTLA-------IPGVLPRFKAEQMMPAIALIVSVIASVVIGGAG 57
           WFS +F   + IVP +LT          P  +       ++P   L V +I   VIGGAG
Sbjct: 158 WFSSEFVNYMTIVPLVLTFPSLRRVDREPKAVATLLRRSVVPTALLAVCIILEWVIGGAG 217

Query: 58  SLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLG 117
           ++AF +PAL+  A+     VT +LT V+ A  +VL A+  + +S  S    P   S ++G
Sbjct: 218 AIAFAMPALVTAALLTNVFVTSVLTAVSTAWTLVLTADGHLGLS--SEGVSPVSASVQIG 275

Query: 118 IATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEA------LKSPSLKQ 171
           ++ +A+ PI V+  +      ++ +      D LT    R               P    
Sbjct: 276 LSLLAVAPIAVACVILERRRALEALTQAVTHDDLTGALRRDEFLRRGGSVTGATDPRRHS 335

Query: 172 TQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVP 231
            + ++V+++D+D+FK +NDN GH  GD  L  FA  +++ + DK L AR+GGEEF V + 
Sbjct: 336 GRPVSVLMMDLDHFKMVNDNLGHRAGDTALVSFADQVRRHLDDKHLFARLGGEEFVVLMA 395

Query: 232 SVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEAD 291
            V+       AE IR+                TVSIGV            D  +L+  AD
Sbjct: 396 GVDLEGATETAEMIRRAQAENSSAVLGD-FGPTVSIGVACS----PHGDADLTQLVDCAD 450

Query: 292 TCLYRSKKDGRNRTSTMRYGE 312
             LYR+KK  RNRT  +  G 
Sbjct: 451 EALYRAKKLDRNRTVALTVGS 471


>UniRef50_C6DJJ8 Diguanylate cyclase n=1 Tax=Pectobacterium carotovorum subsp.
           carotovorum PC1 RepID=C6DJJ8_PECCP
          Length = 480

 Score =  259 bits (662), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 81/322 (25%), Positives = 156/322 (48%), Gaps = 23/322 (7%)

Query: 5   WFSEQFSTGVLIVPCMLT----------LAIPGVLPRFKAEQMMPAIALIVSVIASVVIG 54
           WFSE+ S+GV+ V   L           ++   +   FK    +    +I+  IAS+ I 
Sbjct: 164 WFSEELSSGVIFVFLFLKVTRNVKNIFKISTSSIKKTFKKPLFILYPIIIIFCIASLNIT 223

Query: 55  GAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDI--SVGSPFSIPQMF 112
                   +  LI+ ++ ++     L+   TG     +  N +I++  ++   +     +
Sbjct: 224 ---LSVLAILPLIYLSLSHSFNKIILMCTATGIALNYIYINRLINVHDTIEKEYLFELSY 280

Query: 113 SARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQ- 171
             ++  + + I  ++ SF +      +K++ L ++ D LT + +R  L + + +      
Sbjct: 281 LFQINTSVIIITVLIASFFINKNRKNIKRIELISNHDALTGMLNRRSLNQHMMNIINSTR 340

Query: 172 ---TQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAV 228
               + +++++LDID+FK +ND YGH  GD V+  F+  +++    + L+ R GGEEF +
Sbjct: 341 DGDNKIMSLLVLDIDHFKKVNDTYGHAVGDNVIREFSTTLKQYTRPQDLLCRWGGEEFLI 400

Query: 229 AVPSVNPVDGLLMAEKIRKGVELQPFTW-QQKTLYLTVSIGVGSGRASYLTLTDDFNKLM 287
            +  ++  D L +AE+IR  +E  P        +  T SIGV   +   L   +DF++  
Sbjct: 401 IIQGLSVNDCLDIAERIRSIIEGAPLAISDGHIVRCTTSIGVSFFQ---LERIEDFHEAF 457

Query: 288 VEADTCLYRSKKDGRNRTSTMR 309
            EAD  LY +K+ GRNR ++++
Sbjct: 458 KEADELLYMAKEQGRNRVNSVQ 479


>UniRef50_D0KF92 Diguanylate cyclase n=1 Tax=Pectobacterium wasabiae WPP163
           RepID=D0KF92_PECWW
          Length = 489

 Score =  253 bits (648), Expect = 5e-66,   Method: Composition-based stats.
 Identities = 82/317 (25%), Positives = 152/317 (47%), Gaps = 17/317 (5%)

Query: 5   WFSEQFSTGVLIVPCMLTLA--IPGVLPRFKAEQMM----PAIALIVSVIASVVIGGAGS 58
           WFSE+ S+GV+ V   L +   I  VL   +    M    P   L   +I   +     +
Sbjct: 164 WFSEELSSGVIFVFLFLNITKKIKNVLKISQISIKMTIKKPFFILYPLIIIFCIASSNIT 223

Query: 59  LA-FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDI--SVGSPFSIPQMFSAR 115
           L+   +  LI+ ++  +     ++   TG     +  N +I +   +   +     +  +
Sbjct: 224 LSVLAILPLIYLSLSLSFNKIVVMCSATGIALNYIYINRLIGVHNKIEKEYLFELSYLFQ 283

Query: 116 LGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKS--PSLKQTQ 173
           +  + + I  +  SF +      +K++ L ++ D LT + +R  L + + +   S++  +
Sbjct: 284 INTSVIIITALTASFFINGNRKNIKRIELISNHDALTGMLNRRSLNQHMMNIINSIRDGE 343

Query: 174 H--LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVP 231
           +  +++++LDID+FK IND YGH  GD V+  F+  I++    + L+ R GGEEF + + 
Sbjct: 344 NKMMSLLVLDIDHFKKINDTYGHAVGDNVIRGFSTAIKQHTRPQDLLCRWGGEEFLIIIQ 403

Query: 232 SVNPVDGLLMAEKIRKGVELQPFTW-QQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEA 290
            ++  + L +AE+IR  +E           +  T SIGV      +L   +DF+    EA
Sbjct: 404 GLSKNECLEIAERIRTIIEGSSLAISNGHAVRCTTSIGVSFF---HLERIEDFHDAFKEA 460

Query: 291 DTCLYRSKKDGRNRTST 307
           D  LY +K+ GRNR ++
Sbjct: 461 DKLLYIAKEQGRNRVNS 477


>UniRef50_C3JRE9 Diguanylate cyclase n=2 Tax=Rhodococcus erythropolis
           RepID=C3JRE9_RHOER
          Length = 489

 Score =  252 bits (645), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 87/303 (28%), Positives = 145/303 (47%), Gaps = 12/303 (3%)

Query: 17  VPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQ 76
           +P  L      +  R  A   +P +A    V  ++ I G  +L  P+PAL+WCA R +  
Sbjct: 159 IPSSLAEFRRKLTARTVAALSVPLLATAACVPIALSIEGPIALVLPIPALLWCATRISVP 218

Query: 77  VTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAIN 136
            T  ++ V     +++  +  +DI   +  +  +     + +  +A+ PI V+ +     
Sbjct: 219 STAFVSVVWSVWSLMMAGSGRLDIGDQAASTWNEDVITSIAVTLIALGPIAVACATEERR 278

Query: 137 SLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVMLLDIDYFKSINDNYG 193
           +  +++ L  +FD LT V SR       EA  + + +    + +++LD+D+FKSIND +G
Sbjct: 279 AAERELFLAVEFDHLTGVLSRGAFLGHAEAELADAARTQSPVGLLMLDLDHFKSINDTHG 338

Query: 194 HECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIR-KGVELQ 252
           H  GD VL+ FA      + D  L+ R+GGEEFAV +P  +    + +AE +R   VE  
Sbjct: 339 HMTGDSVLANFAERAADRLSDGDLIGRLGGEEFAVLLPDCSFTRAIDVAEAVRGAQVE-- 396

Query: 253 PFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGE 312
                +  +  TVS+GV     +        + LM  AD  LY +K+ GRN     R G 
Sbjct: 397 --YSAESDVTSTVSVGVAWVDHATPA----LSTLMSVADEALYDAKRAGRNLVKVHRVGN 450

Query: 313 EVV 315
           + V
Sbjct: 451 DTV 453


>UniRef50_Q2RNW0 Putative diguanylate cyclase (GGDEF domain) n=1 Tax=Rhodospirillum
           rubrum ATCC 11170 RepID=Q2RNW0_RHORT
          Length = 360

 Score =  250 bits (638), Expect = 6e-65,   Method: Composition-based stats.
 Identities = 90/274 (32%), Positives = 132/274 (48%), Gaps = 24/274 (8%)

Query: 46  SVIASVVIGGAG-------SLAFPLPALIWCAVRYTPQVTCLL-TFVTGAVEIVLVANSV 97
           +VI +VV+GG         ++ FP+        R    V+ +  T  T  V I+ V +  
Sbjct: 99  AVILTVVLGGKAQDAVFSWAVLFPVLPFFVLGQRLGLLVSIVFATTATVGVTILAVLDGA 158

Query: 98  IDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSR 157
              S  +PF++            +A C ++  F         +Q+   A  D LT + +R
Sbjct: 159 QGFSWIAPFNLA---------GALAGCTVLAYFYEGTRAKAARQLETLAKSDPLTGLANR 209

Query: 158 SGLYEALKSPSL---KQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGD 214
            GL +A     L   +    L++++LD+D+FKSIND YGHE GD VL   A  I+ ++  
Sbjct: 210 RGLLDAFGGAVLTRSRAPHRLSLLVLDLDHFKSINDRYGHEAGDGVLCHVAHVIKGMIRA 269

Query: 215 KGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRA 274
             L+AR+GGEEFA+ +P  +      +AEKIRK +E         +L +TVSIGV     
Sbjct: 270 NDLIARIGGEEFALLLPDTDLAGAREVAEKIRKAIESTALIGPGGSLSVTVSIGVAELDP 329

Query: 275 SYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
            Y     DF  L   AD  LY++KK GRNR S  
Sbjct: 330 QYP----DFAALFSSADHRLYQAKKAGRNRVSAA 359


>UniRef50_C7LVZ4 Diguanylate cyclase n=1 Tax=Desulfomicrobium baculatum DSM 4028
           RepID=C7LVZ4_DESBD
          Length = 483

 Score =  249 bits (637), Expect = 9e-65,   Method: Composition-based stats.
 Identities = 77/293 (26%), Positives = 131/293 (44%), Gaps = 18/293 (6%)

Query: 23  LAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLT 82
           L +PG LP  +  + +  +  + + +    + G    A  L     C     P++  L+T
Sbjct: 201 LFLPGTLPHAQQAEWINHLLSVAARLGKQEVRGYQVSALELKD---CKPGNPPELEELIT 257

Query: 83  FVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQV 142
                  + L +     + + S     ++   RL I + A   + ++          ++ 
Sbjct: 258 L-----PLTLGSEPFGALVICSQ-DASKLGQDRLRILSSAANHLALAMRNGL---EFRKT 308

Query: 143 ALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDK 199
             RAD D LT++ +R      L+    +  +H   L++M++D+DYFKSIND YGH+ GD 
Sbjct: 309 KARADHDGLTRISNRHHFDIRLREEMKRHQRHQDELSLMMIDLDYFKSINDTYGHQAGDM 368

Query: 200 VLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQK 259
           VL    + +   + +    AR GGEEF V +P        ++AE++R  +    F  Q+K
Sbjct: 369 VLQEVGKILNNTLRESDFPARYGGEEFVVILPQTREDQAWILAERLRSQIGQTFFRSQKK 428

Query: 260 TLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGE 312
              +T SIG+   +   LT       L+  ADT LY++K +GRN        E
Sbjct: 429 RFRVTASIGIAGIKPCALTPP---ETLLRNADTALYQAKTNGRNMVCCSAIEE 478


>UniRef50_Q2SME0 Response regulator containing a CheY-like receiver domain and a
           GGDEF domain n=1 Tax=Hahella chejuensis KCTC 2396
           RepID=Q2SME0_HAHCH
          Length = 427

 Score =  249 bits (636), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 71/273 (26%), Positives = 129/273 (47%), Gaps = 15/273 (5%)

Query: 41  IALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVI-- 98
           +A + ++  +++    G++ F +P  IW   R    +  L + V    E        +  
Sbjct: 159 LAYLHTLRETLLFSALGAIVFIIPFGIWEGSRLVRTLNHLTSAVNRMAEGEFKQQVPVKS 218

Query: 99  DISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRS 158
           +  VG+      + + +L  A   +       S   I    +Q+   +  D LT +Y+R 
Sbjct: 219 EDEVGALAKAFNLMNTQLHEAYKNL-----EDSRNKIAKQAEQLKELSIRDELTGLYNRR 273

Query: 159 GLYEA---LKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDK 215
              E    L + +L+      ++L DID+FK IND Y H  GD+VL   A+ +   + + 
Sbjct: 274 FFNEEVKVLHANALRYGNGFCLVLGDIDFFKRINDGYSHVVGDEVLKQVAKILMNSIRNS 333

Query: 216 GLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRAS 275
            +VAR GGEE  +A+P+ +P   + M E+IRK +E  P+    + + +T+S G+      
Sbjct: 334 DIVARYGGEEMVLALPNTSPQAAMEMMERIRKTIEQHPWDSIAEGMKVTMSFGICD---- 389

Query: 276 YLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
             T  + F  ++  AD  LY++K +GRN+  ++
Sbjct: 390 -ETNGEHFEHMLAVADELLYKAKNNGRNQVCSL 421


>UniRef50_A8FZ07 Diguanylate cyclase n=2 Tax=Shewanella RepID=A8FZ07_SHESH
          Length = 298

 Score =  248 bits (635), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 83/284 (29%), Positives = 138/284 (48%), Gaps = 20/284 (7%)

Query: 44  IVSVIAS-VVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISV 102
           I+ V+ S +VI GA  LA  + A +W  VR  P      ++    + I++     +  + 
Sbjct: 4   ILPVLGSGLVISGALLLAMAI-APVWKIVRQLPTGGLRYSWGFLILLILIFIAGYVIYAK 62

Query: 103 GSPFSIPQMFSARLGIATM---AICPIMVSFSVAAINSLMKQ--VALRADFDFLTQVYSR 157
            SP    Q+F   + I          ++ S S+     +M+   +      D L  +++R
Sbjct: 63  FSPVQFSQLFDLVVPIIFFGGAIFVFVVCSLSLRTTRDIMQNYALKQENITDSLMGIFNR 122

Query: 158 SGLYEALKSPSLK---QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGD 214
             L   LK  + +    +Q L++ L+DID+FK +NDNYGH+ GD VL   A+ I+  + +
Sbjct: 123 RYLDRRLKDETERALNYSQPLSIFLIDIDHFKQVNDNYGHQVGDLVLKNIAQLIKHSLRE 182

Query: 215 KGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQK------TLYLTVSIG 268
             ++AR GGEEF V +P         +AE++R  VE    T  ++      ++ +TVSIG
Sbjct: 183 SDVLARFGGEEFVVILPRTKDSTSYTLAERLRHVVEDFQLTLPEESDKDSLSISVTVSIG 242

Query: 269 VGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGE 312
           V    A       D   L+  AD  LY++K++GRN+  T + G+
Sbjct: 243 VAGLNAQ----CKDCQCLIENADRALYQAKRNGRNQVITSKSGK 282


>UniRef50_D1U9C4 Diguanylate cyclase n=1 Tax=Desulfovibrio aespoeensis Aspo-2
           RepID=D1U9C4_9DELT
          Length = 498

 Score =  247 bits (632), Expect = 3e-64,   Method: Composition-based stats.
 Identities = 66/183 (36%), Positives = 103/183 (56%), Gaps = 7/183 (3%)

Query: 132 VAAINSLM-KQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKS 187
           +A  N+L+ K+V LRAD D LT++Y+R    E L     ++ ++   L+++++D+D+FK 
Sbjct: 310 LALRNALIFKEVKLRADRDGLTRIYNRHSFDERLIYEIKRRRRYNHDLSLLMVDLDHFKQ 369

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           +ND YGH+ GD VL      + +      L AR GGEEF V +P  +      +AE+IR+
Sbjct: 370 VNDTYGHKAGDMVLRKVGEILTETFRTTDLAARYGGEEFVVLLPHTSEEAAWKLAERIRE 429

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
            ++   F +      +T SIGV S  A  LT  DD   L+++AD  LY++K +GRN    
Sbjct: 430 SIQGCVFRFDGHEFSVTASIGVASVEAGALTRDDD---LLIKADKALYKAKNNGRNMVVI 486

Query: 308 MRY 310
            R 
Sbjct: 487 SRP 489


>UniRef50_Q4KDW8 GGDEF domain protein n=6 Tax=Pseudomonas RepID=Q4KDW8_PSEF5
          Length = 315

 Score =  246 bits (628), Expect = 9e-64,   Method: Composition-based stats.
 Identities = 59/181 (32%), Positives = 95/181 (52%), Gaps = 4/181 (2%)

Query: 128 VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKS 187
           V+ +  A+    +Q+   +  D LTQ+Y+R    + L+    +    + +++LDID+FKS
Sbjct: 137 VAINSLALQKANQQLQHLSRTDHLTQLYNRGHWEQRLQFEYSRHGSSIALLMLDIDHFKS 196

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           IND +GH+ GD V+   +  I + V D  +  R GGEEFA+ +P  +      +AE++R+
Sbjct: 197 INDRHGHQAGDAVIKRVSELIHQHVRDSDVAGRYGGEEFAILLPHTDLAGARTLAERLRQ 256

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
            VE Q      + +  T+S+G+            D   L+  AD  LY SK+ GRNR ST
Sbjct: 257 SVEEQEVIHNGQAIAFTISLGIACLDRPAR----DHRCLIEWADQALYASKRAGRNRVST 312

Query: 308 M 308
            
Sbjct: 313 Y 313


>UniRef50_B5JX81 Diguanylate cyclase n=1 Tax=gamma proteobacterium HTCC5015
           RepID=B5JX81_9GAMM
          Length = 384

 Score =  245 bits (627), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 85/336 (25%), Positives = 151/336 (44%), Gaps = 38/336 (11%)

Query: 1   MLADWFSEQFSTGVLIVPCMLTL---------------AIPGVLPRFKAEQMMPAIALIV 45
           ML +  + + +   +IV  +L                 A    L      Q   A+ +++
Sbjct: 53  MLGNGLNNEVANTAIIVILVLAACCGIGFILGFKADATAWTSKLYAHICIQFFVAVNMVL 112

Query: 46  SVIASV--VIGGAGSLAFPLPALIWCAVR------YTPQVTCLLTFVTGAVEIVLVANSV 97
           +  A V  V+ G   +   L   I    R      +T  +  L   +  A+E++  A+ +
Sbjct: 113 AYYAGVFSVVSGVALVGGSLTGFILFNERVVYGGLFTGALATLALIILSALEVIPYASVI 172

Query: 98  IDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMK---QVALRADFDFLTQV 154
              + G+P      +   L   +     ++V+ + +AI    +   +V   +  D LTQV
Sbjct: 173 --ETNGTPLHHNATWLILLLGLSTPYIGLLVAMNSSAIRRWRQRESEVRQLSTTDPLTQV 230

Query: 155 YSRSGLYEALKSPSLKQTQH----LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQK 210
            +R  L E L     +  +     L+++++D+D+FKSIND +GH  GD+ L V AR +++
Sbjct: 231 ANRRHLLERLNLEISRCERSGHSELSLLMMDLDHFKSINDEHGHLFGDEALRVTARVLRE 290

Query: 211 IVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKT-LYLTVSIGV 269
              +  LV R GGEEF + +P   P   L +AE+ R+ +E      +    L++T SIG+
Sbjct: 291 QSRNTDLVGRYGGEEFCLLLPDTGPQGALQIAERCRQALEQADIDREDGEVLHITTSIGL 350

Query: 270 GSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
            + +     + D    L+  AD  LY++K+ GRNR 
Sbjct: 351 ATYQ-----MGDTNESLLHRADEALYQAKEQGRNRI 381


>UniRef50_A8V0B5 Diguanylate cyclase (GGDEF domain) n=1 Tax=Hydrogenivirga sp.
           128-5-R1-1 RepID=A8V0B5_9AQUI
          Length = 463

 Score =  245 bits (627), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 67/232 (28%), Positives = 113/232 (48%), Gaps = 12/232 (5%)

Query: 80  LLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLM 139
           L+TF+        +   ++  S  + + I  + S    I    +  +++ FSV      +
Sbjct: 240 LITFIPVFNLNNHLMGYLVRYSKDNTYPI-ILKSFYTNITLSFLLAVILGFSVYIFLKDL 298

Query: 140 KQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHEC 196
           ++    ++ D LT +Y++    E L+     + +  + L++++ DID+FK IND YGH+ 
Sbjct: 299 EKFRYLSETDRLTGLYNKGKFNEVLQREIQRAKRYKRPLSLIIFDIDHFKKINDTYGHKV 358

Query: 197 GDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTW 256
           GD+VL   A+ I+K +      AR GGEEF +  P  N      +AEK+R+ VE   F  
Sbjct: 359 GDEVLKALAKLIKKNIRKTDFAARWGGEEFVILAPETNVEGAKKLAEKLRQAVETYKFPT 418

Query: 257 QQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
             K   +T+S+GV       L   +     +V AD  LY++K+ GRNR    
Sbjct: 419 VGK---VTISLGVAQ-----LEPDEKPEDFIVRADMALYKAKEGGRNRVEIA 462


>UniRef50_Q310L5 Diguanylate cyclase (GGDEF domain) n=2 Tax=Desulfovibrio
           RepID=Q310L5_DESDG
          Length = 525

 Score =  245 bits (626), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 68/186 (36%), Positives = 105/186 (56%), Gaps = 7/186 (3%)

Query: 127 MVSFSVAAINSLM-KQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDI 182
           M   ++A  N+L+ +++ L+AD D LTQ+++R      L+    +  +    LT+M+LDI
Sbjct: 331 MRHLALAVKNALLFREMRLQADHDGLTQLHNRRHFDTRLREELDRHGRYSMPLTLMMLDI 390

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           DYFK IND +GH+ GD VL   A  +++ +      AR GGEEF   +P  +     ++A
Sbjct: 391 DYFKQINDRFGHQAGDAVLRELASVLRETIRTTDYCARYGGEEFVAILPHTDEQQARVLA 450

Query: 243 EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           E++RK +E + F    KT+  TVSIG+   +   LT  D   +L+ EAD  LY +K +GR
Sbjct: 451 ERLRKNIESRVFRHHGKTIQATVSIGLTGFKPGALTPRD---ELVREADAALYLAKANGR 507

Query: 303 NRTSTM 308
           N   T 
Sbjct: 508 NVVCTF 513


>UniRef50_B8DLP9 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfovibrio
           vulgaris str. 'Miyazaki F' RepID=B8DLP9_DESVM
          Length = 730

 Score =  245 bits (626), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 60/179 (33%), Positives = 90/179 (50%), Gaps = 8/179 (4%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKS 187
                    +++   A  D LT + +R    EAL+    +  +    L ++ +D+D FK 
Sbjct: 535 DTTEHREAQERLRQLATTDGLTGLANRRRFLEALEHEVQRHRRYGTPLALISIDVDRFKR 594

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           +ND +GH  GD+VL   A   +  V D   V R+GGEEFAV +P   P + + +AE++R 
Sbjct: 595 VNDTWGHAVGDEVLRALAGICRAEVRDVDTVGRIGGEEFAVLLPDTAPEEAMAVAERLRA 654

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
           GVE  P       L +T+S+GV +         D  + L+ EAD  LYR+K  GRNR  
Sbjct: 655 GVEAAPLLTTAGPLTVTLSLGVSASPPC-----DGADTLLREADRALYRAKAGGRNRVE 708


>UniRef50_A3WKT4 GGDEF domain protein n=2 Tax=Alteromonadales RepID=A3WKT4_9GAMM
          Length = 364

 Score =  245 bits (626), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 94/327 (28%), Positives = 141/327 (43%), Gaps = 45/327 (13%)

Query: 14  VLIVPCMLTLAIP--------------GVLPRFKAEQMMPAIALIV------SVIASVVI 53
           V      L L  P                   F   + M AI+LI       S + +++I
Sbjct: 32  VAFFFIFLILNSPILAWVNLLSIAMYLTAYWAFGQRKNMLAISLIWLEVLYHSALGTLMI 91

Query: 54  GGAGSLAFPLPAL---IWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQ 110
           G      + L      I+ ++   P V  LL      + + L        S   P   P 
Sbjct: 92  GWDSGFHYFLLMFVPAIFVSMSLKPAVLTLLGLWVYYLSLDLF-------SWYYPAMQPI 144

Query: 111 MFSARLGIATMAICPIMVSFSVAAINSLMK------QVALRADFDFLTQVYSRSGLYEAL 164
             +A +G+    +  + + F   A+  L K      Q+   A  D LT++ +R  + E L
Sbjct: 145 NATAVVGVHIFNLTVVFIMFGYLALYYLNKVNLTHDQLRFYATTDPLTKLRNRRHMSELL 204

Query: 165 KSPSL---KQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARM 221
           K        + ++++V+LLD+D+FKS+ND +GHE GDKVL + A  ++  V D   V+R 
Sbjct: 205 KRALQNKHAEQRNVSVLLLDLDHFKSVNDTHGHEVGDKVLRITADILRDTVRDHDKVSRW 264

Query: 222 GGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP-FTWQQKTLYLTVSIGVGSGRASYLTLT 280
           GGEEF V +P  N      +AE+IRK +   P  T   + + LT SIGV   +       
Sbjct: 265 GGEEFLVFLPRTNLNHAAQVAERIRKAIAKYPWHTVINENIQLTTSIGVSELKPD----- 319

Query: 281 DDFNKLMVEADTCLYRSKKDGRNRTST 307
           D  N L+  AD  LYR K+ GRN    
Sbjct: 320 DSVNTLVKRADDALYRGKEAGRNWVEL 346


>UniRef50_C4XS30 GGDEF domain protein n=1 Tax=Desulfovibrio magneticus RS-1
           RepID=C4XS30_DESMR
          Length = 498

 Score =  243 bits (620), Expect = 7e-63,   Method: Composition-based stats.
 Identities = 58/171 (33%), Positives = 91/171 (53%), Gaps = 6/171 (3%)

Query: 140 KQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHEC 196
            QV +RAD D LT++++R    E L     +  ++   ++++++DID+FK IND YGH  
Sbjct: 313 NQVKIRADHDGLTRIHNRRAFDERLIDELRRHQRYRHAMSLLMVDIDHFKGINDRYGHLV 372

Query: 197 GDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTW 256
           GD VL      + + +      AR GGEEF V +P        ++AE++R  +    F  
Sbjct: 373 GDHVLREVGSILSETLRSTDFTARYGGEEFVVILPQTAEEQARILAERLRGAIAEARFVH 432

Query: 257 QQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
             +   +TVSIGV + +   LT   D   L+ +AD  LY++K  GRN+  T
Sbjct: 433 DGEDFSITVSIGVSALQPGALTRRKD---LLEKADKALYQAKHLGRNQVCT 480


>UniRef50_D2L2K3 Diguanylate cyclase with GAF sensor n=1 Tax=Desulfovibrio sp.
           FW1012B RepID=D2L2K3_9DELT
          Length = 499

 Score =  243 bits (620), Expect = 7e-63,   Method: Composition-based stats.
 Identities = 62/183 (33%), Positives = 93/183 (50%), Gaps = 11/183 (6%)

Query: 141 QVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGHECG 197
           QV +RAD D LT++++R    E L     +  +    +++++LDID+FK IND YGH  G
Sbjct: 314 QVKVRADHDGLTRIHNRRAFDERLVEELRRHQRYHHPMSLLMLDIDHFKGINDTYGHLVG 373

Query: 198 DKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ 257
           D VL    R + + +      AR GGEEF + +P        ++AE++R  +    F   
Sbjct: 374 DHVLREVGRLMTETLRSTDFTARYGGEEFVIILPQTAEEQSRVLAERLRGLIADARFVHD 433

Query: 258 QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM-----RYGE 312
                +TVSIG  +     L+   D   L+ +AD  LY++K  GRN+  T      R GE
Sbjct: 434 GHPFSITVSIGAATLLPGALSKRKD---LLDKADKALYQAKTLGRNQVCTALGPVSRTGE 490

Query: 313 EVV 315
           E V
Sbjct: 491 EAV 493


>UniRef50_Q1N175 Diguanylate cyclase (GGDEF domain) n=1 Tax=Bermanella marisrubri
           RepID=Q1N175_9GAMM
          Length = 294

 Score =  241 bits (617), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 63/202 (31%), Positives = 104/202 (51%), Gaps = 14/202 (6%)

Query: 116 LGIATMAICPIMVSFSVAAINSLMKQVALR------ADFDFLTQVYSRSGLYEALKSPSL 169
           LG     I P  +S  +A + S +++          A  D LT +Y+R   +E  +    
Sbjct: 97  LGAVDYVIKPYSLSVLLARVRSALREKERLDLMEKWATTDPLTGLYNRRFFFEQAQRELE 156

Query: 170 KQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEF 226
           +  ++    + ++LDID+FK +ND YGH  GD VL   A+  ++      L  R GGEEF
Sbjct: 157 RVQRNETDASFIILDIDHFKKVNDEYGHLVGDDVLEGLAKLFKETFRKVDLCCRFGGEEF 216

Query: 227 AVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKL 286
            + +P  +    LL+AE+ RK VE   F  ++  L++T+S+GV S   +          +
Sbjct: 217 VICLPDTDTEGALLVAERTRKKVEELSFNTEKGPLHVTISLGVSSANENT-----TLEDM 271

Query: 287 MVEADTCLYRSKKDGRNRTSTM 308
           +  AD  LY++K++GRNRT ++
Sbjct: 272 LKRADDALYQAKQNGRNRTESL 293


>UniRef50_C6BW86 Diguanylate cyclase n=1 Tax=Desulfovibrio salexigens DSM 2638
           RepID=C6BW86_DESAD
          Length = 555

 Score =  241 bits (615), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 58/180 (32%), Positives = 95/180 (52%), Gaps = 3/180 (1%)

Query: 134 AINSLMKQVALRADFDFLTQVYSRSGLYE---ALKSPSLKQTQHLTVMLLDIDYFKSIND 190
            ++  ++++   A  D LT + +R  L +    L   +++  Q  ++M++DID+FK IND
Sbjct: 364 KVDRTVQELQKSAVTDQLTGLPNRRYLMKEGTRLVDIAIRAGQPCSLMIMDIDHFKVIND 423

Query: 191 NYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVE 250
            YGH  GD VL   ++  Q++V    ++AR GGEEF V  P  +   G  +AE++R+ VE
Sbjct: 424 TYGHTVGDIVLQQISKAFQEVVRSSDIIARYGGEEFVVVAPGSDIDSGRTLAERLRQSVE 483

Query: 251 LQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRY 310
            + F   ++ L  T+SIGV           D +  ++  AD  LY++K  GRNR      
Sbjct: 484 ARIFNNDEQPLTCTISIGVSHYATDIKFGVDAYEDMLARADNALYKAKDTGRNRICIAEP 543


>UniRef50_C6WYA7 Diguanylate cyclase with PAS/PAC and GAF sensors n=1
           Tax=Methylotenera mobilis JLW8 RepID=C6WYA7_METML
          Length = 591

 Score =  240 bits (614), Expect = 4e-62,   Method: Composition-based stats.
 Identities = 59/184 (32%), Positives = 96/184 (52%), Gaps = 8/184 (4%)

Query: 126 IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDI 182
           I  S  +     L +++  +A  DFLT V +R    E  +    + ++    L+  +LDI
Sbjct: 407 IGTSTDITERKQLEEELKRQARIDFLTGVSNRRYFMEQAEQEIQRTSRYDTPLSFFMLDI 466

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           D FK +ND YGH+ GD VL   A   ++ + +  ++ R+GGEEFA+ +P  +      +A
Sbjct: 467 DLFKQVNDTYGHKSGDIVLKRMASVCRETLREIDIIGRVGGEEFAILLPETDKAQAAEVA 526

Query: 243 EKIRKGVELQPFTWQ-QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
           E++R  +  +    +    +  TVSIGV S  +S     D+ + L+  AD  LY++KK G
Sbjct: 527 ERLRSVLADEKVPTEAGAPIQFTVSIGVASRVSSQ----DNIDMLLNLADEALYQAKKYG 582

Query: 302 RNRT 305
           RNR 
Sbjct: 583 RNRV 586


>UniRef50_B4U6Y8 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Hydrogenobaculum
           sp. Y04AAS1 RepID=B4U6Y8_HYDS0
          Length = 772

 Score =  240 bits (614), Expect = 4e-62,   Method: Composition-based stats.
 Identities = 56/187 (29%), Positives = 93/187 (49%), Gaps = 11/187 (5%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLL 180
             +     +     L   +  ++  D LT +Y+R  L   L+     + +  + L++++ 
Sbjct: 593 VAVFTFVDITKEKELSDMLLKQSTEDPLTGIYNRRYLENKLEEYVKLAKRHDRPLSLIMF 652

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DID+FK IND++GH+ GDKVL   A+ + + + +  + AR GGEEF +  P     D  +
Sbjct: 653 DIDFFKHINDSFGHDVGDKVLKAIAKVVSENIRNTDIFARYGGEEFVIIAPETTKEDAKI 712

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           +AEK+R  +    F   ++ + +T S GV S     L   D    L+  AD  LY +KK 
Sbjct: 713 LAEKLRSLIRNLHF---EEGINVTCSFGVAS-----LEKHDTKETLLKRADEALYEAKKT 764

Query: 301 GRNRTST 307
           GRN+   
Sbjct: 765 GRNKVVV 771


>UniRef50_B1WQB8 Putative diguanylate cyclase n=2 Tax=Cyanothece RepID=B1WQB8_CYAA5
          Length = 493

 Score =  240 bits (612), Expect = 7e-62,   Method: Composition-based stats.
 Identities = 74/256 (28%), Positives = 122/256 (47%), Gaps = 16/256 (6%)

Query: 58  SLAFPLPALIWCAVRYTPQVTCLLTF-VTGAVEIVLVANSVIDISVGSPFSIPQMFSARL 116
            +A+PL  L   A R T +    L   VT   E+  +A S+  +       I ++  AR 
Sbjct: 241 IIAYPLEQLTHIAQRVTQESNFQLKAPVTTQDEVGKLATSMNQLIQWIDEHITELKEARQ 300

Query: 117 GIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH-- 174
            +         V      +   +K++    + D LTQ+++R    E L     +  +   
Sbjct: 301 TLEKR------VEQRTIELQQALKKLKALVNLDGLTQIFNRRYFDEVLYREWQRGRREKS 354

Query: 175 -LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIV-GDKGLVARMGGEEFAVAVPS 232
            ++++L D+DYFK  N+ YGH  GD  L   A+ I++ V     LVAR GGEEF + +P+
Sbjct: 355 VISLILCDVDYFKIYNETYGHLGGDSCLQEVAQGIRRQVKRPSDLVARYGGEEFVILLPN 414

Query: 233 VNPVDGLLMAEKIRKGVELQPFTWQQKTL--YLTVSIGVGSGRASYLTLTDDFNKLMVEA 290
            +    L +AE IR  +E      +   +  ++T+S+GV S        TD++  L+ EA
Sbjct: 415 TDLNGALALAEMIRNAIEAMNIPHENSLVSDHVTISMGVTSK---IPQETDEYEHLIEEA 471

Query: 291 DTCLYRSKKDGRNRTS 306
           D  LY++K++GRN   
Sbjct: 472 DDALYQAKENGRNCVC 487


>UniRef50_B3EBI3 Diguanylate cyclase n=1 Tax=Geobacter lovleyi SZ RepID=B3EBI3_GEOLS
          Length = 307

 Score =  240 bits (612), Expect = 8e-62,   Method: Composition-based stats.
 Identities = 57/173 (32%), Positives = 89/173 (51%), Gaps = 8/173 (4%)

Query: 138 LMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGH 194
              ++   A  D LT V++R  L   L+    +  +H   L++M+LDID+FK IND +GH
Sbjct: 131 YEHKLIQMAKVDGLTGVFNRRYLDTRLQEELERSRRHGNPLSIMMLDIDHFKEINDTHGH 190

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
            CGD  L   +  + ++V    ++ R GGEEF   +P  +    L++AE+ R  V    F
Sbjct: 191 ICGDYTLRKISELLLELVRTSDILGRYGGEEFCCILPETSFEQALVLAERCRTQVAASQF 250

Query: 255 TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
           +       +TVSIGV       L   D  + ++  AD  LY++K+ GRNR  +
Sbjct: 251 SCTDHQSRVTVSIGVTD-----LHRDDTLDSIIKRADDALYQAKRTGRNRVCS 298


>UniRef50_D1U434 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfovibrio
            aespoeensis Aspo-2 RepID=D1U434_9DELT
          Length = 1051

 Score =  239 bits (611), Expect = 8e-62,   Method: Composition-based stats.
 Identities = 55/198 (27%), Positives = 99/198 (50%), Gaps = 10/198 (5%)

Query: 113  SARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQT 172
            S +LG    A+  I     +    +   ++   A  D LT +++R    E  +   ++  
Sbjct: 860  SFQLGGRWYAVATI---RDITERKATEARLHELATTDSLTGLFNRRRFMELAEREFMRTK 916

Query: 173  QH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVA 229
            ++   LT++++DID+FK +ND +GH  GD+VL   AR  +  + +  ++ R+GGEEF V 
Sbjct: 917  RYQGALTMLMMDIDHFKRVNDTHGHGVGDEVLRELARISRTALRELDILGRLGGEEFGVL 976

Query: 230  VPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVE 289
            +P  +    + +A+++R+ +E         TL +TVSIG  +         +    L+  
Sbjct: 977  LPETDAGPAMEVAQRLRRAIEKASMATDAGTLRITVSIGAATSN----NDAETVETLLKR 1032

Query: 290  ADTCLYRSKKDGRNRTST 307
            AD  LY +K+ GRN+   
Sbjct: 1033 ADVALYEAKQSGRNKVVA 1050


>UniRef50_C0QM24 Putative uncharacterized protein n=1 Tax=Desulfobacterium
           autotrophicum HRM2 RepID=C0QM24_DESAH
          Length = 488

 Score =  238 bits (609), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 58/199 (29%), Positives = 96/199 (48%), Gaps = 10/199 (5%)

Query: 118 IATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQH 174
           + +  I  +++  +   I S  K++   A  D LT VY+R       +       ++   
Sbjct: 291 VFSFGIIGLILIVTNLTIASFQKRLTKMASTDKLTGVYNRRAFDIIIDQTLKEIQRKQTP 350

Query: 175 LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVN 234
           L+++L D+D+FK +ND YGH  GD ++        + + +  ++ R GGEEF + +   +
Sbjct: 351 LSIILFDLDHFKRVNDTYGHLAGDYIIQTTVGTAARTIRNSDILCRWGGEEFLILLKGCD 410

Query: 235 PVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCL 294
             D +  AEKIR  V  QP  +    + +T+S+GV        T  D    L+  AD  L
Sbjct: 411 LGDAMKTAEKIRTAVASQPARYGDDQICVTISVGVTEH-----TGQDTKETLLKRADKAL 465

Query: 295 YRSKKDGRNR--TSTMRYG 311
           Y +K  G+NR  T T+R G
Sbjct: 466 YLAKASGKNRCETETVRPG 484


>UniRef50_C8X5B9 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8X5B9_DESRD
          Length = 578

 Score =  238 bits (608), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 57/182 (31%), Positives = 90/182 (49%), Gaps = 6/182 (3%)

Query: 129 SFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYF 185
           +  +       + +   A  D LT +Y+R    E L +    + +  Q L ++ LDID+F
Sbjct: 399 AQDITERKRAEEHLRYLATTDELTGLYNRRHFMEILDTEIERAKRYEQSLALISLDIDHF 458

Query: 186 KSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKI 245
           K+IND +GH  GD  L   A  +         + R+GGEEFA+  P  +      +AE+I
Sbjct: 459 KTINDTHGHAVGDAALEHLAAQLLACKRQPDSLGRLGGEEFALIAPHTDRAGATELAERI 518

Query: 246 RKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
           R  +E  P   +  +L+ T+S+GV +     +   D  + L+  AD  LY +K+ GRNRT
Sbjct: 519 RSELERTPIELESTSLHPTISLGVTALN---IQDNDTIDALLKRADDALYEAKRTGRNRT 575

Query: 306 ST 307
            T
Sbjct: 576 VT 577


>UniRef50_B8FCK6 Response regulator receiver modulated diguanylate cyclase n=1
           Tax=Desulfatibacillum alkenivorans AK-01
           RepID=B8FCK6_DESAA
          Length = 301

 Score =  238 bits (608), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 68/272 (25%), Positives = 123/272 (45%), Gaps = 13/272 (4%)

Query: 40  AIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVID 99
           A+A I   +  + +   G   + +   I  +         +LT      + V    +   
Sbjct: 40  AVATIKPDLILLDLIMPGMDGYAVCEKIKGSPATADIPVIMLTSKAETADKVRGLEAGAS 99

Query: 100 ISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSG 159
             V  PF   ++ +            + +     ++    +Q+   A+ D LT +Y+   
Sbjct: 100 DYVTKPFEEGELVAR-------VNTHLRIKELYESLQETNRQLQELANRDGLTGLYNHRY 152

Query: 160 LYEALK---SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKG 216
             +A+      +++  + L+ +L DID+FK  ND YGH+ GD VLS  AR ++  + D  
Sbjct: 153 FQDAMTKDFQRAMRYHESLSCVLCDIDFFKKFNDTYGHQTGDIVLSTLARIVEDSLRDTD 212

Query: 217 LVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASY 276
           L AR GGEEFA+ +         ++AE++R+ VE   F     +L +T+S+GV +     
Sbjct: 213 LAARYGGEEFALVLYHTPAAAAFMVAERLRESVEQHEFIANDLSLSVTISVGVATYPHPD 272

Query: 277 LTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
           +    D   L+  AD  LY++K++GRN+  + 
Sbjct: 273 IP---DHKTLIECADKALYKAKENGRNQVISF 301


>UniRef50_B8FMG8 Diguanylate cyclase n=1 Tax=Desulfatibacillum alkenivorans AK-01
           RepID=B8FMG8_DESAA
          Length = 417

 Score =  238 bits (607), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 66/206 (32%), Positives = 112/206 (54%), Gaps = 5/206 (2%)

Query: 108 IPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP 167
           I    +A + ++ +++  I+VS     +    + + + +  D LT++++R      L   
Sbjct: 209 IASGLTAAISLSLLSMIWILVSRLARRLTKAYETIEVMSITDELTRLHNRRHFETRLAEE 268

Query: 168 ---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGE 224
              SL+    +++M+LDID+FK +NDNYGH+ GD VL+ FA  ++  V    + AR GGE
Sbjct: 269 ISRSLRYGSPMSLMILDIDHFKRVNDNYGHQAGDWVLTQFATLLKDNVRKADVPARWGGE 328

Query: 225 EFAVAVPSVNPVDGLLMAEKIRKGVELQPFTW-QQKTLYLTVSIGVGSGRA-SYLTLTDD 282
           EF V +         + AEK+R+ VE   F     +++ +TVS+GV S    S   +  +
Sbjct: 329 EFVVILTESTISQARMAAEKVRRNVESAEFNIPDGRSIPVTVSVGVASLDMISGDEMGSE 388

Query: 283 FNKLMVEADTCLYRSKKDGRNRTSTM 308
            + L+  AD  LYR+K++GRNRT  +
Sbjct: 389 ADVLVKTADDALYRAKQEGRNRTVAV 414


>UniRef50_A0LD73 Diguanylate cyclase n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0LD73_MAGSM
          Length = 513

 Score =  238 bits (607), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 75/243 (30%), Positives = 117/243 (48%), Gaps = 18/243 (7%)

Query: 73  YTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSV 132
           +     C+    +G V  V+      D++V  P+ IP +              +  S SV
Sbjct: 270 HPLGFYCMPVLHSGTVGNVVQLVVEPDMAVMFPYIIPFL-----------QVFLRESSSV 318

Query: 133 AAINSLMKQVALRADFDFLTQVYSRSGLYEA---LKSPSLKQTQHLTVMLLDIDYFKSIN 189
                LM+++   A  D LT + +R  L E    + + S ++   L+V+++D+D+FK +N
Sbjct: 319 IESKRLMEKLRESALKDPLTGLNNRRFLEEYERTIVASSQRKEMFLSVLMMDLDHFKMVN 378

Query: 190 DNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGV 249
           D +GH+ GD VL   A  + +      LV R GGEEF V + +  P  G  +AEKIR+ V
Sbjct: 379 DTHGHQVGDAVLKSLAGVLMQQTRASDLVVRYGGEEFMVVLQNERPHMGNQIAEKIRETV 438

Query: 250 ELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
           E          L  T+SIGV      + T   DF+ ++ +AD  LYR+K+ GRNR  +  
Sbjct: 439 ERLKINVPGGCLQKTISIGVAE----FPTDGTDFDDVVEKADMALYRAKEQGRNRVISHS 494

Query: 310 YGE 312
             E
Sbjct: 495 ASE 497


>UniRef50_C6WYA9 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Methylotenera
           mobilis JLW8 RepID=C6WYA9_METML
          Length = 548

 Score =  237 bits (606), Expect = 3e-61,   Method: Composition-based stats.
 Identities = 58/190 (30%), Positives = 102/190 (53%), Gaps = 8/190 (4%)

Query: 123 ICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVML 179
           I  I V  ++ +   L  ++  +A  D+LT++ +R    E  +     S +  + + + +
Sbjct: 362 IRMIGVHANIHSRKLLELELNQKAHIDYLTELNNRGHFMEQAEKELSRSQRYQKDMAMFM 421

Query: 180 LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGL 239
           +DID+FK IND++GH+ GD VL   A   ++ + +  ++ R+GGEEFA+ +P  N  + L
Sbjct: 422 MDIDFFKKINDSHGHKIGDIVLKKLADVCRQTLREVDIIGRIGGEEFAILLPETNRAEAL 481

Query: 240 LMAEKIRKGVELQPFTWQQK-TLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSK 298
            +AE++R  V       +    +  TVSIGV S  ++     D+ + L+  AD  LY++K
Sbjct: 482 EVAERLRLAVADSKVPMKDGLPVQYTVSIGVSSVASA----DDNIDMLLSRADQALYQAK 537

Query: 299 KDGRNRTSTM 308
           + GRNR    
Sbjct: 538 QSGRNRVCAA 547


>UniRef50_A5GCU4 Diguanylate cyclase n=2 Tax=Geobacter RepID=A5GCU4_GEOUR
          Length = 422

 Score =  237 bits (606), Expect = 3e-61,   Method: Composition-based stats.
 Identities = 60/243 (24%), Positives = 115/243 (47%), Gaps = 12/243 (4%)

Query: 69  CAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMV 128
           C      ++  ++  ++  + +V +        +    +        LGI       +++
Sbjct: 189 CHRSQGYKIGSVMGALSVTIPVVTLIRETDTDKLMIVAATIGTIGLLLGITYFLTWRLVL 248

Query: 129 SFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQ---TQHLTVMLLDIDYF 185
           +  +A      K +   A  D LT + +R  + + L     +     + L +++LD+D+F
Sbjct: 249 NLDMA-----QKHLKRLASTDELTGLKNRRQIMKRLDEEYQRAIRLGEPLCLIMLDLDHF 303

Query: 186 KSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKI 245
           K IND YGH  GD VL   A H++K +    ++ R+GGEEF +  P     + +++A+++
Sbjct: 304 KKINDTYGHPFGDLVLKCVAGHMKKALRRYDVLGRIGGEEFLIVSPGTTREEAVVLAQRL 363

Query: 246 RKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
           R  VE++   ++ K + +TVS GV           D+   L+  AD+ LY +K++GRNR 
Sbjct: 364 RSTVEMEKIAYEDKKVTITVSCGVAFLYKG----DDNVEILLKRADSALYIAKQEGRNRV 419

Query: 306 STM 308
             +
Sbjct: 420 VAI 422


>UniRef50_B3E6Y7 Diguanylate cyclase n=1 Tax=Geobacter lovleyi SZ RepID=B3E6Y7_GEOLS
          Length = 459

 Score =  237 bits (606), Expect = 3e-61,   Method: Composition-based stats.
 Identities = 55/184 (29%), Positives = 85/184 (46%), Gaps = 8/184 (4%)

Query: 132 VAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSI 188
           +  +    +++   A  D LT + +R    E ++    +  +       +LLDID FK I
Sbjct: 277 LKELREAQEKLVEMATIDSLTGLLNRRAGLERVEEELSRHQRSERAFACLLLDIDRFKKI 336

Query: 189 NDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKG 248
           ND YGH+ GD VLS F   +++ V    +V R GGEEF + +P  +P      AEKIR  
Sbjct: 337 NDTYGHQAGDAVLSEFGATLRRHVRKHDIVCRYGGEEFLLLLPDTSPSAARTTAEKIRAV 396

Query: 249 VELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
               P  +  + + +T SIG+       +   +    ++  AD  LY +K  GRNR    
Sbjct: 397 TAATPIMFAGRQIAVTTSIGIS-----MMQGDETAKAMIARADAALYEAKNSGRNRVVCA 451

Query: 309 RYGE 312
              E
Sbjct: 452 EANE 455


>UniRef50_B8DLV9 Diguanylate cyclase n=4 Tax=Desulfovibrio vulgaris
           RepID=B8DLV9_DESVM
          Length = 381

 Score =  237 bits (605), Expect = 4e-61,   Method: Composition-based stats.
 Identities = 79/294 (26%), Positives = 126/294 (42%), Gaps = 27/294 (9%)

Query: 27  GVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTG 86
           G   R         +AL    +  V  GG     F     +W  + + P V        G
Sbjct: 79  GRTGRHVLPSTALVLALFTLSLYMVSHGGVEGSGF-----VWLFI-FPPVVMLTFGLSIG 132

Query: 87  AVEI--VLVANSVIDISVGSPF---SIPQMFSARLGIATMAICPIMVSFSVAAINS---- 137
            + +  +L+    I    G PF      Q F  R  +A +  C I    +          
Sbjct: 133 ILLMGALLLGVGAILFLPGDPFLYADYSQAFRIRYMLALL-CCGIFAGLAEYTRRHTQRL 191

Query: 138 ---LMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDN 191
              L +Q+A  A  D LT + +R  L E L+     + +  + L++ + DID+FKS+ND 
Sbjct: 192 LILLTQQLAESARTDELTGLANRRALCERLEYEQVRARRTGRPLSIAICDIDHFKSVNDC 251

Query: 192 YGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVEL 251
           YGH+CGD VL   A  +   +  +  + R GGEEF + +P  +      +AEK+R  VE 
Sbjct: 252 YGHQCGDLVLQSVAGLLHDNLRHQDTICRWGGEEFLLLLPETDEAGAARLAEKLRSLVEA 311

Query: 252 QPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
             +++    + +T+S GV +          D +  + +AD  LY +K+ GRNR 
Sbjct: 312 MEYSYHGIPVSVTLSFGVHTCGPEG-----DIDYHIRKADQKLYLAKEQGRNRV 360


>UniRef50_Q47W79 GGDEF domain protein n=1 Tax=Colwellia psychrerythraea 34H
           RepID=Q47W79_COLP3
          Length = 334

 Score =  237 bits (605), Expect = 4e-61,   Method: Composition-based stats.
 Identities = 55/177 (31%), Positives = 101/177 (57%), Gaps = 7/177 (3%)

Query: 133 AAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSIN 189
             +   + ++A  +  D LTQVY+R    ++L+    K  +H   L++++LD+D+FK +N
Sbjct: 155 MQLQKTLAEIAQISRIDGLTQVYNRRHWQDSLEQEYAKARRHDKKLSLIMLDLDHFKLLN 214

Query: 190 DNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGV 249
           DNYGH+ GD VL   +  I  ++  +    R GGEEFA+ +P  +    + +A++I + +
Sbjct: 215 DNYGHQGGDMVLIEVSALISTLLRVEDTFGRYGGEEFAIILPETDSAGAIELAQRICRII 274

Query: 250 ELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
              PFT+  + + +TVS+GV    +       ++ +L+ +AD+ LY++K  GRN+  
Sbjct: 275 ATTPFTYNDQVIKVTVSLGVAQLSS----KESNYEELITQADSALYQAKSQGRNQVC 327


>UniRef50_C1A5L7 Putative two-component response regulator n=1 Tax=Gemmatimonas
           aurantiaca T-27 RepID=C1A5L7_GEMAT
          Length = 491

 Score =  237 bits (605), Expect = 4e-61,   Method: Composition-based stats.
 Identities = 62/194 (31%), Positives = 98/194 (50%), Gaps = 8/194 (4%)

Query: 117 GIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQ 173
            + T A+  I  +  V +  +   ++   A  D LTQ+ +R  L E + +    +L+   
Sbjct: 299 AVITAAVAVIQRAQMVESTMADNARLEQLAQTDPLTQLLNRRALTERITAEMERALRYDS 358

Query: 174 HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSV 233
            L ++++D+D+FK +ND YGH  GD VL    + +   +    + AR GGEEF V +P  
Sbjct: 359 TLALLMIDLDHFKKVNDTYGHLVGDDVLRDVGQLLGHTIRGSDITARYGGEEFLVLLPET 418

Query: 234 NPVDGLLMAEKIRKGVELQPFTWQQ--KTLYLTVSIGVGSGRASYLTLTDDFNKLMVEAD 291
           +    +  AE+IR  +E  PF      + L LT SIGV    A+ +   ++   L   AD
Sbjct: 419 DDAGAVAFAERIRVAMEEHPFARDSMAEPLKLTASIGVAVFPAARI---ENVEDLFARAD 475

Query: 292 TCLYRSKKDGRNRT 305
             LYR+K +GRNR 
Sbjct: 476 AALYRAKAEGRNRV 489


>UniRef50_A4VQQ9 GGDEF domain protein n=1 Tax=Pseudomonas stutzeri A1501
           RepID=A4VQQ9_PSEU5
          Length = 466

 Score =  236 bits (604), Expect = 6e-61,   Method: Composition-based stats.
 Identities = 64/200 (32%), Positives = 102/200 (51%), Gaps = 9/200 (4%)

Query: 111 MFSARLGIATMAICPIMVSF--SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPS 168
           + S  L +  + I  +   +  S+A +     Q+A  A+ D LT V SR      L++  
Sbjct: 269 VISLALSVVALLIFLLSSRYFQSIARLRLAHGQLAQLANTDVLTGVSSRRAFLAGLEAEL 328

Query: 169 LKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEE 225
            +  +H   L++++LDID+FK +ND +GH  GD VL  F+     ++    L+ R+GGEE
Sbjct: 329 ARARRHNESLSLLMLDIDHFKRVNDVHGHPIGDAVLKQFSETCAGMLRAHDLLGRLGGEE 388

Query: 226 FAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNK 285
           FA+ +P  +      +AEKIR  V   P       + +TVSIG+         L  + ++
Sbjct: 389 FAIVLPHTDAEGARCVAEKIRTAVAQTPMPTAAGDITVTVSIGLAQMEG----LPGEVDQ 444

Query: 286 LMVEADTCLYRSKKDGRNRT 305
           LM  AD  LY +K+ GRN+ 
Sbjct: 445 LMARADQALYEAKRGGRNQV 464


>UniRef50_A6DDS7 Diguanylate cyclase (GGDEF domain) n=1 Tax=Caminibacter
           mediatlanticus TB-2 RepID=A6DDS7_9PROT
          Length = 750

 Score =  236 bits (604), Expect = 6e-61,   Method: Composition-based stats.
 Identities = 63/182 (34%), Positives = 95/182 (52%), Gaps = 12/182 (6%)

Query: 130 FSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKS---PSLKQTQHLTVMLLDIDYFK 186
           + ++ I  L KQ+   A +D LT +Y+R+     LK     S +    L+++ LDIDYFK
Sbjct: 578 YQLSKIKKLSKQLETMAFYDKLTNIYNRAKFKNILKEFIEYSKRYKTPLSLIFLDIDYFK 637

Query: 187 SINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIR 246
            INDN+GHE GD VL    +  +  + +  +  R GGEEF + +P+ +     ++AEKIR
Sbjct: 638 KINDNFGHEKGDLVLKEMVKVAKLSLRESDVFGRWGGEEFLILLPNTDINGAKIVAEKIR 697

Query: 247 KGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
             +E   F      + +TVS+GV       L   D     +  AD  LY++KK+GRNR  
Sbjct: 698 DAIESHDF----DGIKVTVSLGVTQ-----LKEDDTIESFVNRADIALYQAKKEGRNRVV 748

Query: 307 TM 308
             
Sbjct: 749 VF 750


>UniRef50_C0QT79 Signal transduction response regulator n=1 Tax=Persephonella marina
           EX-H1 RepID=C0QT79_PERMH
          Length = 509

 Score =  236 bits (603), Expect = 7e-61,   Method: Composition-based stats.
 Identities = 60/202 (29%), Positives = 95/202 (47%), Gaps = 14/202 (6%)

Query: 109 PQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK--- 165
                + +GI  +    + +SF +  I    ++    A+ D LT +Y++      L+   
Sbjct: 308 NTFIISYVGINLLVGLLLTMSFILGVIK---ERFKAMAEIDTLTGIYNKGKFNHLLQVEL 364

Query: 166 SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEE 225
             S +  + L++++ DID+FK IND +GH+ GD VL   A+ +   +      AR GGEE
Sbjct: 365 DRSKRYGRPLSLIIFDIDHFKKINDAFGHQAGDYVLKTLAKIVSSNIRSTDFFARWGGEE 424

Query: 226 FAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNK 285
           F +  P  +     ++AEKIRK +E  PF    K   +T S GV           D  + 
Sbjct: 425 FVILAPETDLEGAQILAEKIRKAIEEYPFETVGK---VTSSFGVTEAF-----ENDTVDS 476

Query: 286 LMVEADTCLYRSKKDGRNRTST 307
            +  AD  LY++K  GRNR   
Sbjct: 477 FVKRADVALYKAKDKGRNRVEI 498


>UniRef50_C6BU46 Diguanylate cyclase n=1 Tax=Desulfovibrio salexigens DSM 2638
           RepID=C6BU46_DESAD
          Length = 490

 Score =  236 bits (603), Expect = 8e-61,   Method: Composition-based stats.
 Identities = 65/182 (35%), Positives = 99/182 (54%), Gaps = 7/182 (3%)

Query: 130 FSVAAINSLM-KQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYF 185
            S+A  N++M  ++  RA+ D LT+VY+R    E L     +  +    L+++++D+DYF
Sbjct: 302 LSLALSNAIMFNKIKTRANRDGLTRVYNRRSFDERLVEEFKRHQRLNTELSLLMVDLDYF 361

Query: 186 KSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKI 245
           K++ND YGH  GD VL   AR  +K       +AR GGEEF + +P        ++AE+I
Sbjct: 362 KAVNDTYGHMAGDMVLEKVARMFEKTFRSTDFIARYGGEEFVILLPHTREDQAEMLAERI 421

Query: 246 RKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
           R  +E    T+Q K+  +T SIGV S R   L       +++ +AD  LY +K  GRNR 
Sbjct: 422 RAKIESCAMTYQDKSFNITASIGVSSVRPGSLEKDT---EIVRKADEALYDAKMQGRNRV 478

Query: 306 ST 307
             
Sbjct: 479 VV 480


>UniRef50_Q07Y51 Diguanylate cyclase n=2 Tax=Alteromonadales RepID=Q07Y51_SHEFN
          Length = 359

 Score =  235 bits (600), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 89/319 (27%), Positives = 151/319 (47%), Gaps = 25/319 (7%)

Query: 1   MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALI-VSVIASVVIGGAGSL 59
           ++ +WF++ F    ++   ++ L I G+L   KA   +    L+ +  + SV++ G  S 
Sbjct: 33  VVNNWFND-FKLYAMVELAVVCLCI-GILFIHKATPNLTLWCLVFLFALYSVILIGIYSA 90

Query: 60  AFPLPALIWC----AVRYTPQVTCLLTFVTGAVEI----VLVANSVIDISVGSPFSIPQM 111
           +F      W      + Y      L T  T    I    +LV   ++DI+   P +I   
Sbjct: 91  SFNSGLFTWLFIIPVLSYLLLGIKLGTLYTCVYMIGGVGILVNALLLDIATIYPITI--- 147

Query: 112 FSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSR---SGLYEALKSPS 168
             A + +   AI  +  S+      + ++++   A  D LT + +R     +++ L    
Sbjct: 148 --ANIVLCLAAIWALSFSYEYKRAEA-VERLQKMASLDPLTGLNNRLLLDSIFDMLCESL 204

Query: 169 LKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAV 228
            +Q Q ++V++LD+D+FK IND YGH+ GDKVL   +R I  +        R+GGEEF +
Sbjct: 205 PEQHQSVSVLILDLDHFKRINDQYGHDVGDKVLVEVSRIINSVRRQNDWAFRLGGEEFCM 264

Query: 229 AVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMV 288
            +P  N      +AE++RK VEL         L L++SIGV      +      F+++  
Sbjct: 265 LIPDSNLQQAGQIAERLRKAVELVTV-IDGSELNLSISIGVSR----WPEDGAHFSQIYK 319

Query: 289 EADTCLYRSKKDGRNRTST 307
            AD  LY++K  GRN+  T
Sbjct: 320 TADARLYQAKTLGRNKVIT 338


>UniRef50_C7LRA7 Diguanylate cyclase n=1 Tax=Desulfomicrobium baculatum DSM 4028
           RepID=C7LRA7_DESBD
          Length = 495

 Score =  235 bits (599), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 59/204 (28%), Positives = 98/204 (48%), Gaps = 8/204 (3%)

Query: 113 SARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLK-- 170
           S  L +    +  ++V   +  +N   +++AL A  D LT   +R    E+      +  
Sbjct: 296 SIVLVLVVAGLSTLLVRGQI-RLNRQSRELALAASTDMLTGALNRRAFMESASREFARVC 354

Query: 171 -QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVA 229
               HL+ +++D+D+FK++ND YGH  GD VLS  A +I   + +  +  R GGEEF + 
Sbjct: 355 RYGGHLSCIMIDLDHFKNVNDTYGHAAGDLVLSSSAHYIASRLREPDMFCRYGGEEFVIL 414

Query: 230 VPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVE 289
           +P  +      +AE++R G+         + L LT S GV    A   T     + L+  
Sbjct: 415 LPGTDRNGAATVAEELRAGLAGLDLQRGDEKLPLTASFGVAEIHAQCAT----LDTLLSL 470

Query: 290 ADTCLYRSKKDGRNRTSTMRYGEE 313
           AD  LY +K++GRNR       ++
Sbjct: 471 ADQALYEAKENGRNRVCLAPRQQQ 494


>UniRef50_C4LFT4 Diguanylate cyclase n=1 Tax=Tolumonas auensis DSM 9187
           RepID=C4LFT4_TOLAT
          Length = 392

 Score =  234 bits (598), Expect = 3e-60,   Method: Composition-based stats.
 Identities = 74/243 (30%), Positives = 117/243 (48%), Gaps = 14/243 (5%)

Query: 72  RYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFS 131
           R    +TC+L      +  +            S   +    S  L +  + I  + +SFS
Sbjct: 154 RLMFALTCILATAGSLLRFLTYQ------YEPSYSLLNTNISNLLLVFNVIIVLLGLSFS 207

Query: 132 VAAINS--LMKQVALRADFDFLTQVYSRSGLYEA----LKSPSLKQTQHLTVMLLDIDYF 185
           +  I S  L +++A  A +D LT +Y+R GL E       S         +V ++DIDYF
Sbjct: 208 IMLITSQWLQQKLAAFASYDALTGIYNRYGLNEQSAALFNSDGKLSATDYSVAMIDIDYF 267

Query: 186 KSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKI 245
           K  ND+YGH  GD VL   A  +++ +    ++AR GGEEF V +P  N  D L  AE++
Sbjct: 268 KKTNDDYGHPVGDAVLKEVAERLRQNIRHHDILARYGGEEFIVVLPGTNITDALHWAERV 327

Query: 246 RKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
           R  V  +P    Q  + +T+SIGV +           F++ + +AD  LY++K++GRN+ 
Sbjct: 328 RAQVAAKPIQVDQHAIQITLSIGVVALPGKDKHSA--FDEAIRQADIALYQAKENGRNQV 385

Query: 306 STM 308
              
Sbjct: 386 RCF 388


>UniRef50_C6C0X5 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfovibrio
           salexigens DSM 2638 RepID=C6C0X5_DESAD
          Length = 779

 Score =  234 bits (598), Expect = 3e-60,   Method: Composition-based stats.
 Identities = 55/180 (30%), Positives = 94/180 (52%), Gaps = 7/180 (3%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKS 187
            V        ++   A  D LT + +R    E+ +     + +  + L+++++DIDYFK+
Sbjct: 594 DVTERKEAEDKLRKLATTDSLTGLSNRRFFMESAEDALERTRRYGRDLSLLMMDIDYFKT 653

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           +ND YGH+ GD VL   ++   KI+ +  +  R+GGEEF++ +P        L+AE++R 
Sbjct: 654 VNDMYGHDAGDDVLKGLSKTGLKILRNIDVFGRIGGEEFSILLPDTGLDGATLVAERLRA 713

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
            +E      +  +L +TVSIGV +    Y   T    +L+  AD  LY +K+ GRN+   
Sbjct: 714 EIETTKMNTRSGSLNITVSIGVAT----YSEHTKTLEQLLKAADIGLYAAKEAGRNQVKV 769


>UniRef50_B5JW02 Diguanylate cyclase n=1 Tax=gamma proteobacterium HTCC5015
           RepID=B5JW02_9GAMM
          Length = 595

 Score =  234 bits (597), Expect = 3e-60,   Method: Composition-based stats.
 Identities = 69/313 (22%), Positives = 120/313 (38%), Gaps = 16/313 (5%)

Query: 5   WFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPA--------IALIVSVIASVVIGGA 56
           W +       L +P    + +  +         + A          +    + S  +   
Sbjct: 274 WAASGLVVASLFLPYFYVIRVLIICTILACVMGLFAGFYRQVEGYGVARFYLYSWSLFML 333

Query: 57  GSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARL 116
           G++   L            + + L     G V +       ++      +   Q  + R+
Sbjct: 334 GAILVALNKFDVLPSNMITEYSMLFGTGVGTVVLSAALAVRLNDEKNKRYH-AQAEALRV 392

Query: 117 GIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ--- 173
              ++ +    V    +A+    +++   ++ D LT + +R  L E L     +  +   
Sbjct: 393 QRESVELLEERVKERTSALREANEKLEKLSNTDSLTGLNNRRSLDELLAMEVKRTCRTGA 452

Query: 174 HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIV-GDKGLVARMGGEEFAVAVPS 232
            L+ M++DID FK+ ND +GH+ GD  L   A  I         +V R GGEEF V +P 
Sbjct: 453 PLSAMMMDIDRFKAFNDTHGHQVGDACLKAVAGVIASTAQRPSDVVGRYGGEEFCVLLPD 512

Query: 233 VNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADT 292
                  ++AE+IR  VE   FT   + + +T+SIGV          +D    L+  AD 
Sbjct: 513 TPLDGAQIIAERIRAAVENLDFTVSGQRVPVTISIGVSELT---YCASDSGKALVEAADE 569

Query: 293 CLYRSKKDGRNRT 305
            LY +K  GRN  
Sbjct: 570 ALYSAKSAGRNCV 582


>UniRef50_C6BVV0 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfovibrio
           salexigens DSM 2638 RepID=C6BVV0_DESAD
          Length = 838

 Score =  234 bits (597), Expect = 4e-60,   Method: Composition-based stats.
 Identities = 59/187 (31%), Positives = 99/187 (52%), Gaps = 8/187 (4%)

Query: 126 IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDI 182
           I V++ V        Q+   A  D +T++ +R    E +KS    S++ ++ L++++ D+
Sbjct: 651 IGVNWDVTESREKENQLRRMATTDDMTKLNNRRYFIELVKSEIERSIRYSRPLSLVMFDV 710

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           D FK++ND YGH+ GD VL   A   + ++ D  ++ R+GGEEFAV +P  +    +L+A
Sbjct: 711 DKFKAVNDTYGHDVGDMVLKAIAATAKGVLRDVDIIGRLGGEEFAVGLPETDLKGAMLLA 770

Query: 243 EKIRKGVELQPFTWQQKTL-YLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
           E++R  +E          +   TVS+GV     S      D + L+  AD  LY +K++G
Sbjct: 771 ERLRVVLEEASVELPDGGIVDFTVSLGVAVLDRSIT----DVDVLLKHADLALYAAKENG 826

Query: 302 RNRTSTM 308
           RNR    
Sbjct: 827 RNRVEAY 833


>UniRef50_Q15V65 Diguanylate cyclase n=1 Tax=Pseudoalteromonas atlantica T6c
           RepID=Q15V65_PSEA6
          Length = 370

 Score =  234 bits (597), Expect = 4e-60,   Method: Composition-based stats.
 Identities = 80/318 (25%), Positives = 146/318 (45%), Gaps = 32/318 (10%)

Query: 7   SEQFSTGVLIVPCM-LTLAIPGVLPRFKAEQ------MMPAIALIVSVIASVVIGGAGSL 59
           ++ F  GV ++    L      +L  F+++        +   AL++ ++  +V GG  + 
Sbjct: 58  NDDFYLGVTLLVASALFFTSRLILKFFQSKNGYKVSANLVTGALMLLMLYLIVTGGVKN- 116

Query: 60  AFPLPALIWCAVRYTPQVTCLLTFVTGAVEI--VLVANSVIDISVGSPFSIPQM---FSA 114
                  +W  +   P V        G +++        VI    G+ F + Q    FS+
Sbjct: 117 ----TGPLWIYI-VPPVVLFFGGLKRGLIQLGCFAFVAIVILEYPGNLFLMAQYSDEFSS 171

Query: 115 RLGIATMAICPIMVSFSVAA------INSLMKQVALRADFDFLTQVYSRSGLYEALK--- 165
           RL  + + +  + V +  +       +  L ++   +A  D L+ + +R G+ E L+   
Sbjct: 172 RLIYSFITVSLLFVFYEYSRQRSFKTLQELSREFEKQARLDPLSGLQNRRGMLEKLEYEH 231

Query: 166 SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEE 225
             +L+  ++LT+M+ DID+FK +ND +GH+ GD V++   +   K +  +  VAR GGEE
Sbjct: 232 QRTLRHHKNLTLMMCDIDHFKRVNDKFGHDVGDGVITQVGQLFDKALRKQDTVARWGGEE 291

Query: 226 FAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNK 285
           F   +P         +AEK+R  V  Q +     +  +TVS+G+           D+ + 
Sbjct: 292 FLFLLPETTQEQAFTLAEKLRAQVSKQQYQAGSDSFTVTVSLGIYQMHPQ-----DNLDH 346

Query: 286 LMVEADTCLYRSKKDGRN 303
            +  ADT LYR+K +GRN
Sbjct: 347 AISRADTNLYRAKSNGRN 364


>UniRef50_Q4KKJ4 Diguanylate cyclase, putative n=5 Tax=Pseudomonas fluorescens
           RepID=Q4KKJ4_PSEF5
          Length = 727

 Score =  234 bits (597), Expect = 4e-60,   Method: Composition-based stats.
 Identities = 59/176 (33%), Positives = 97/176 (55%), Gaps = 8/176 (4%)

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDN 191
               +++   +A  D LT + +R+   E L+    +  QH   L + +LD+D+FK INDN
Sbjct: 556 YREHLEEQRQKALIDPLTGLPNRAAWSERLEHEVGQWQQHGNSLLLAMLDLDHFKRINDN 615

Query: 192 YGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVEL 251
           YGH  GDKVL + A  ++K +     +AR GGEEF + +P+     G+ + E +R  +E 
Sbjct: 616 YGHLAGDKVLKIIANVLRKRLRGSDFIARFGGEEFVLLLPNTPWPVGVRIVEALRAAIEA 675

Query: 252 QPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
            PF ++ + + +TVS+G+ + +A      D  + ++  AD  LYR+K  GRNR   
Sbjct: 676 CPFHFKGEPVTITVSVGLSAFKA-----GDRSDLVIKRADQALYRAKDAGRNRVEA 726


>UniRef50_A9WIR5 Diguanylate cyclase n=3 Tax=Chloroflexus RepID=A9WIR5_CHLAA
          Length = 589

 Score =  234 bits (597), Expect = 4e-60,   Method: Composition-based stats.
 Identities = 61/231 (26%), Positives = 111/231 (48%), Gaps = 22/231 (9%)

Query: 99  DISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLM----------------KQV 142
           +++ GS  + P +   R+  A +       ++++A +N+L                  Q+
Sbjct: 355 ELADGSLLAAPLIVGDRIIGALLVWSNHHDAYTMADLNALELLAATVAVALHNAFRFAQI 414

Query: 143 ALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGHECGDK 199
             +A  D LT + +R    + L     +  +    +++ ++D+D+FK IND +GH  GD 
Sbjct: 415 QSQAITDNLTGLANRRHFLQVLHQEMERNRRYHTPVSIAMIDVDHFKQINDTFGHIAGDY 474

Query: 200 VLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQK 259
           VL   AR  ++ + D  ++AR GGEEF + +P       L   E++R  +   P     +
Sbjct: 475 VLREIARRCRQQLRDVDVLARYGGEEFGLILPETTYEQALKATERLRTVLATTPIMIDGR 534

Query: 260 TLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRY 310
            +  T+SIGV S    + T+  D + L+ +AD  LY +K+ GRNR   ++ 
Sbjct: 535 QINPTISIGVASF---HPTVYPDPSSLIADADRALYLAKQQGRNRVCGVQE 582


>UniRef50_Q39ZK6 Response regulator receiver modulated diguanylate cyclase n=8
           Tax=Geobacter RepID=Q39ZK6_GEOMG
          Length = 314

 Score =  234 bits (597), Expect = 4e-60,   Method: Composition-based stats.
 Identities = 58/178 (32%), Positives = 99/178 (55%), Gaps = 6/178 (3%)

Query: 134 AINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSIND 190
            +    + +   +  D LT +++R  L E +     + ++    L++++LDIDYFK IND
Sbjct: 130 ELKRSNEMLRTLSITDPLTHLHNRRHLMEMVDKEFQRSSRKGAPLSLVILDIDYFKKIND 189

Query: 191 NYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVE 250
            YGH+ GD+VL++ A  +++ +    L AR GGEEF + +P     + L +AE++R  V+
Sbjct: 190 TYGHQEGDRVLTILADIVRRRLRSYDLAARYGGEEFVLLLPETPVQEALSIAERLRLEVQ 249

Query: 251 LQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
              F      L +T+S+GV +  +S +   +  + L  +AD  LYR+K+ GRNR   M
Sbjct: 250 EHVFEGSLGGLVITISLGVATYPSSRV---ESIDSLFRQADEALYRAKQGGRNRVELM 304


>UniRef50_D0SXM5 Predicted protein n=2 Tax=Acinetobacter lwoffii SH145
           RepID=D0SXM5_ACILW
          Length = 440

 Score =  234 bits (597), Expect = 4e-60,   Method: Composition-based stats.
 Identities = 78/293 (26%), Positives = 133/293 (45%), Gaps = 15/293 (5%)

Query: 25  IPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFV 84
           I  +     A   +  +AL +S   +  I    S  F L A +      T     +   +
Sbjct: 129 ILPIGTTVAAAAWIGLLALSISPHVATYI--YASAIFILIANL---CVQTQFKVAVYCSI 183

Query: 85  TGAVEIVLVANSVIDISVGSPFS--IPQMFSARLGIATMAICPIMVSFSVAAINSLMKQ- 141
             A+ I+L  +  +  S    FS     ++   + I    I  +  SF  + ++    Q 
Sbjct: 184 LIALFIMLGVSQFMSASQAFIFSVVFSPLWFFSIYINWNNILNVRRSFLRSLLDEWNYQT 243

Query: 142 VALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLT--VMLLDIDYFKSINDNYGHECGDK 199
           +   A  D LTQ+Y+R    +  +    +  +H +  +++ D+D+FK+IND+YGH+ GD+
Sbjct: 244 LKNLAHTDDLTQLYNRRHFVDMAERSIHQWPKHASSCLLMFDVDHFKNINDSYGHDVGDR 303

Query: 200 VLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ-Q 258
           VL + A   +K +    ++AR GGEEF   +      D L++AE+IR  ++ Q    +  
Sbjct: 304 VLQLIAEVTRKEMRHSDVLARFGGEEFIALLEDTQLQDSLVIAERIRCAIQKQYIYVEPN 363

Query: 259 KTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYG 311
            T+  T+SIGV    +     T     L+ +AD  LY++KK GRNR       
Sbjct: 364 HTIRFTISIGVAELESH----TQPLEDLIKQADIALYQAKKSGRNRIEVYHPD 412


>UniRef50_Q489Q4 Sensory box/GGDEF domain protein n=1 Tax=Colwellia psychrerythraea
           34H RepID=Q489Q4_COLP3
          Length = 451

 Score =  233 bits (596), Expect = 4e-60,   Method: Composition-based stats.
 Identities = 67/211 (31%), Positives = 107/211 (50%), Gaps = 18/211 (8%)

Query: 100 ISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSG 159
           IS   PF  P    A +G +T           V  +  L ++  L A+ D LT +Y+R  
Sbjct: 253 ISTKVPFDRPDKLPALIGFST----------DVTELFKLKEEFKLLANTDPLTNLYNRRF 302

Query: 160 LYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKG 216
             E  +    +  ++   +T++ +DID+FKSIND +GH  GD+VL   A+ ++  +    
Sbjct: 303 FIEQAEKEYQRAKRYSLSMTLISIDIDHFKSINDQFGHPAGDQVLIEIAKQLKASLRQTD 362

Query: 217 LVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ-QKTLYLTVSIGVGSGRAS 275
           ++AR+GGEEF++ +P  + +  +  AE+I++       T   Q  + L+VSIGV S  AS
Sbjct: 363 ILARIGGEEFSILLPETSAMSAMTFAERIKEEQSRLIITGDWQGEINLSVSIGVSSLIAS 422

Query: 276 YLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
                  F+ L   AD  LY++K  GRN   
Sbjct: 423 ----DKAFDVLFSRADKALYQAKNTGRNTVC 449


>UniRef50_Q21PN7 GGDEF domain n=1 Tax=Saccharophagus degradans 2-40
           RepID=Q21PN7_SACD2
          Length = 565

 Score =  233 bits (596), Expect = 5e-60,   Method: Composition-based stats.
 Identities = 55/234 (23%), Positives = 99/234 (42%), Gaps = 10/234 (4%)

Query: 78  TCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINS 137
             L    +   + +    + +     +  +  Q  SA+L      +    V        +
Sbjct: 338 NSLPDLQSTVSDHIRTIQNALSTFKQAQPAPSQSLSAQLKALMDRVKT--VEEESEKSRA 395

Query: 138 LMKQVALRADFDFLTQVYSRSGLYEALKSPS---LKQTQHLTVMLLDIDYFKSINDNYGH 194
            +++   +A  D LT + +R    E          +    LT+ + D+D+FK IND +GH
Sbjct: 396 QLEEQRYKATHDPLTSLPNREAYNERAFHELHRFKRYGHPLTLAVCDLDHFKKINDTFGH 455

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
           + GDKVL + A+ +   + +   VAR GGEEF + +P  +      + +K+R  +   PF
Sbjct: 456 QAGDKVLKLVAQVVSTRLRNVDFVARYGGEEFVLVMPETDAEQAKTVLDKMRAAIAKTPF 515

Query: 255 TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
            ++   + +T+S G+   R       D        AD  LY +K +GRN+    
Sbjct: 516 RFKDSPVTITMSFGIVQFRGE-----DSVESAFARADKALYEAKANGRNQCVIA 564


>UniRef50_Q2BQS0 GGDEF family protein n=1 Tax=Neptuniibacter caesariensis
           RepID=Q2BQS0_9GAMM
          Length = 314

 Score =  233 bits (596), Expect = 5e-60,   Method: Composition-based stats.
 Identities = 56/188 (29%), Positives = 97/188 (51%), Gaps = 7/188 (3%)

Query: 122 AICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSL---KQTQHLTVM 178
               I ++ ++     L +++   A+ D +T  Y+R    E++        +     ++ 
Sbjct: 129 IAAVIWLAINITEKKRLEQRLKDLAEKDPMTGAYNRRFFRESIDQHYATFKRYGTTYSLA 188

Query: 179 LLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDG 238
            +DIDYFK +ND +GH+ GD V+     HIQ+ +    L++R GGEEF V  P +N  + 
Sbjct: 189 FIDIDYFKKVNDQFGHDVGDGVICHLVTHIQEQLRTTDLLSRFGGEEFVVLFPHINLDEA 248

Query: 239 LLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSK 298
            L+AE++R  +E+ P+      +  TVSIG+   RA      +    ++  AD+ LY+SK
Sbjct: 249 CLVAERLRATIEMTPYKSINHKVPFTVSIGISEVRAE----DESVEDILKRADSALYQSK 304

Query: 299 KDGRNRTS 306
             GRN+ +
Sbjct: 305 SSGRNKVT 312


>UniRef50_A8UV88 Putative uncharacterized protein n=1 Tax=Hydrogenivirga sp.
           128-5-R1-1 RepID=A8UV88_9AQUI
          Length = 475

 Score =  233 bits (596), Expect = 5e-60,   Method: Composition-based stats.
 Identities = 60/171 (35%), Positives = 94/171 (54%), Gaps = 8/171 (4%)

Query: 146 ADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLS 202
           A  D LT + +R    E  ++    S +  + L+++++DID FKSINDNYGH+ GD VL 
Sbjct: 307 AYTDPLTGLNNRRFFMENARTIIDLSKRYREPLSLLMMDIDNFKSINDNYGHDVGDLVLK 366

Query: 203 VFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY 262
             A  I+K V    + AR GGEEF V +P  +    L++AE+IR            K ++
Sbjct: 367 KLAEVIRKNVRTSDIPARFGGEEFVVLLPRTDEKGALMVAERIRNEFRNSSVKVDGKDIW 426

Query: 263 LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEE 313
            +VSIG+       L+  DD + L+ +AD  LY++K+ G++R    R  ++
Sbjct: 427 TSVSIGLS-----VLSEEDDIDSLIKKADEALYQAKRSGKDRVVIYREEDQ 472


>UniRef50_A3Y6S3 PAS:GGDEF protein n=1 Tax=Marinomonas sp. MED121 RepID=A3Y6S3_9GAMM
          Length = 299

 Score =  233 bits (596), Expect = 5e-60,   Method: Composition-based stats.
 Identities = 57/183 (31%), Positives = 94/183 (51%), Gaps = 7/183 (3%)

Query: 126 IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDI 182
           + +   V        ++   +  D LT + +R    E  +    +      H +++ LDI
Sbjct: 117 VSIQRDVTEYIYTQNKLEELSRTDPLTGLINRRVFDEMAEKEFYRYQNQNIHYSLLALDI 176

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           DYFK IND YGH  GD VL+ F+   +K +  +  +AR+GGEEF + +P+ + V  + +A
Sbjct: 177 DYFKRINDKYGHLTGDYVLASFSTLCEKNIRSQDKIARIGGEEFCIILPATDKVGAIEVA 236

Query: 243 EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           EK+R+ +    F   +  + +TVSIGV   + S      D+  ++  AD  LYR+K  GR
Sbjct: 237 EKLRRAISNARFKQDEHEIAVTVSIGVSQVKMSDY----DYVAMLKRADENLYRAKHQGR 292

Query: 303 NRT 305
           N+ 
Sbjct: 293 NQV 295


>UniRef50_A1AK55 Diguanylate cyclase with PAS/PAC sensor n=2 Tax=Desulfuromonadales
           RepID=A1AK55_PELPD
          Length = 301

 Score =  233 bits (595), Expect = 6e-60,   Method: Composition-based stats.
 Identities = 53/177 (29%), Positives = 88/177 (49%), Gaps = 8/177 (4%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKS 187
            V  + +  +++      D LT VY+R  L   LK    +  +     ++M++DID+FK 
Sbjct: 126 DVTELATYEQKLIEMNTVDALTGVYNRRFLESRLKEECDRYGRYSRPFSLMMIDIDFFKK 185

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           +ND +GH+ GD VL   A     ++     +AR GGEEF   +P  +      +AE +R 
Sbjct: 186 VNDTHGHQGGDLVLKNVAAGAAAMIRKSDFLARYGGEEFCCLLPETDCDAAETVAEHLRA 245

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
            +E     +Q+K + +T+S+G+           D    L+  AD  LY++K+ GRNR
Sbjct: 246 HIENMEHLFQKKVIRVTISLGIACFAPD-----DSPETLVKRADEALYQAKRSGRNR 297


>UniRef50_A3WKY5 Signaling protein with a ligand-binding sensor domain and GGDEF
           domain n=2 Tax=Idiomarina RepID=A3WKY5_9GAMM
          Length = 999

 Score =  233 bits (595), Expect = 6e-60,   Method: Composition-based stats.
 Identities = 65/203 (32%), Positives = 101/203 (49%), Gaps = 15/203 (7%)

Query: 116 LGIATMAICPIMVSFSVAAINSLM-------KQVALRADFDFLTQVYSRSGLYEALK--- 165
           LG+A   +    + F       L        K++   A  D LTQ+ +R    E L+   
Sbjct: 802 LGLAATILVRARIRFLNNQRAQLELMVAEKTKELKGLARQDSLTQLGNRRAFDEQLQYEF 861

Query: 166 SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEE 225
               +  Q L++ ++D+D+FKSIND + H  GD+VL   +  +  ++ D   +AR GGEE
Sbjct: 862 KRCERSEQPLSLAIIDVDHFKSINDRFLHVIGDQVLIELSALLSNMLRDIDYIARWGGEE 921

Query: 226 FAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNK 285
           FA+ +P     + L  AE+IR+ +E   +      L +TVSIGV S          + + 
Sbjct: 922 FALLMPETTAKEALQAAERIRQRIEDTSYQHLADELAVTVSIGVASS-----EHYPNHSA 976

Query: 286 LMVEADTCLYRSKKDGRNRTSTM 308
           L+V AD  LY++K+ GRNRT   
Sbjct: 977 LLVAADKALYKAKQSGRNRTELA 999


>UniRef50_Q2SNU2 Response regulator containing a CheY-like receiver domain and a
           GGDEF domain n=1 Tax=Hahella chejuensis KCTC 2396
           RepID=Q2SNU2_HAHCH
          Length = 367

 Score =  233 bits (595), Expect = 6e-60,   Method: Composition-based stats.
 Identities = 77/308 (25%), Positives = 132/308 (42%), Gaps = 24/308 (7%)

Query: 13  GVLIVPCMLTL-AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAV 71
             L + C L L  +         +        +V ++   +I G G        ++W  V
Sbjct: 55  SALFLFCALMLMNVISYNRTLNQQLFKTLFLWLVGLLFLYLIAGGGESN---TGILWFYV 111

Query: 72  RYTPQVTCLLTFVTGAVEIVLVANSVIDIS--VGSPFSIPQM-FSARLGIATMAICPIMV 128
            + P V  +    TG+  ++++   +  I      P+         +L  A       + 
Sbjct: 112 -FPPFVFYVAGLRTGSWMLIIMVALIAIIFRFPELPWVRTVYNLDFQLRFAATVSFVSVF 170

Query: 129 SFSVAAINSLMKQ--------VALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTV 177
           +F +       +Q            A  D LTQ+ +R  + + L+    +  +H    +V
Sbjct: 171 AFVMDHSRRKARQELINMARLYEKAARTDELTQLPNRRDMQQQLEKEYFRYKRHGSHFSV 230

Query: 178 MLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVD 237
           +LLDID+FK IND YGH+ GD VL   +  +        + AR GGEEF + +P  + V 
Sbjct: 231 ILLDIDHFKMINDTYGHDAGDFVLMKISELLVNACRKMDMAARWGGEEFLIQLPDTSLVQ 290

Query: 238 GLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRS 297
            L +AE++RK +E  P  ++ + +  T+S GV S     ++   D   L+ +AD  LY++
Sbjct: 291 ALTLAERLRKSIEASPLQYKNQEIRYTISCGVCS-----ISQAKDLASLLKQADVNLYQA 345

Query: 298 KKDGRNRT 305
           K  GRN  
Sbjct: 346 KIKGRNMV 353


>UniRef50_Q30QX5 Diguanylate cyclase n=2 Tax=Proteobacteria RepID=Q30QX5_SULDN
          Length = 564

 Score =  233 bits (595), Expect = 6e-60,   Method: Composition-based stats.
 Identities = 80/326 (24%), Positives = 140/326 (42%), Gaps = 31/326 (9%)

Query: 9   QFSTGVLIVPCMLTLAIPGVLPR-------FKAEQMMPAIALIVSVIASVVIGGAG---- 57
           +F+ G+++ P  L L I  +           K    +  ++L   +   +    A     
Sbjct: 239 KFNFGMMLSPIFLALFIQTIFKTKEQYINEHKLLNSIIFVSLANFIYGLIDFNSALEIMS 298

Query: 58  -SLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARL 116
            SL + L   +W ++R   +   L+     A  + L+  SV  +      +     S+  
Sbjct: 299 SSLTYALIVFMWISIRICKKGDKLIKIFLIAHTLYLIF-SVYALLYYLGIADANYISSHG 357

Query: 117 GIATMAICPIMVSFSVA-----------AINSLMKQVALRADFDFLTQVYSRSGLYE--- 162
               + I  +++S+ V+                  ++ L A  D +T++Y+R    E   
Sbjct: 358 TSIGLIIEAMLLSYLVSYKFIIMEQEKEEEKLKQIELKLLASTDSMTKLYNRRYFTEISA 417

Query: 163 ALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMG 222
            +   S ++  +L+++++DID FK +ND YGH+ GD+VL   +R + +      +V R G
Sbjct: 418 KVLHLSKREKNNLSILMIDIDRFKVVNDTYGHQFGDEVLIALSRLLVEHQRKSDIVCRYG 477

Query: 223 GEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ-QKTLYLTVSIGVGSGRASYLTLTD 281
           GEEF + +P+ +  D   +A+KIR  VE         K    T+SIGV       +   D
Sbjct: 478 GEEFVILLPNTSLKDATNIAQKIRILVESLTMEAPTNKEFKFTISIGVAQID---VEHED 534

Query: 282 DFNKLMVEADTCLYRSKKDGRNRTST 307
           D    +  AD  LYR+K  GRNR   
Sbjct: 535 DIKFALKRADDALYRAKNSGRNRVCA 560


>UniRef50_A1ASG6 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Pelobacter
           propionicus DSM 2379 RepID=A1ASG6_PELPD
          Length = 505

 Score =  233 bits (595), Expect = 7e-60,   Method: Composition-based stats.
 Identities = 63/178 (35%), Positives = 97/178 (54%), Gaps = 11/178 (6%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKS 187
            +     + +++   ++ D LT +Y+R  LY+ L    + + +    LT+MLLDID+FK 
Sbjct: 318 DITERTRMQEELREASERDPLTSLYNRRKLYQLLTVELTRTRRHGHPLTLMLLDIDHFKR 377

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           IND +GH+ GD VL+  A  I  I+    ++AR GGEEF +A P  +     ++AEKIR 
Sbjct: 378 INDTFGHDSGDLVLTQVAELISAILRSTDILARYGGEEFVIACPETDMDGAAVLAEKIRS 437

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
            + +  F        +T+S+G+       L   DD N L+  ADT LY +K+ GRNR 
Sbjct: 438 SIAMFSFPTVG---AVTISVGISL-----LESKDDINALIKRADTALYAAKEMGRNRV 487


>UniRef50_C0N773 GGDEF domain protein n=1 Tax=Methylophaga thiooxidans DMS010
           RepID=C0N773_9GAMM
          Length = 462

 Score =  233 bits (595), Expect = 7e-60,   Method: Composition-based stats.
 Identities = 68/268 (25%), Positives = 126/268 (47%), Gaps = 14/268 (5%)

Query: 48  IASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFS 107
           I+ + I G     + +   I   +     +      VT       + N+ + +S      
Sbjct: 202 ISHIKINGILDQRYAMSVGIRSDLPLLLSIYNKAIAVTTEETRQQILNNWLSLSFHQNVD 261

Query: 108 IPQMFSARLGIATMAICP----IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEA 163
           +  ++   + IA +        ++V+     +  + K++   +  D LT +++R  L +A
Sbjct: 262 LTWLWRMLIVIAVVVALFFYRYLLVNQHNRELQRVNKKLEQLSQRDHLTGIHNRYYLDQA 321

Query: 164 LKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVAR 220
            +    +  ++    T+++LDID FK IND+YGH  GD V+   A  +++ V D+ +VAR
Sbjct: 322 FQQELTRYKRYQHGFTIVMLDIDLFKQINDSYGHVVGDDVIKQIAMLLREHVRDQDVVAR 381

Query: 221 MGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLT 280
            GGEEF +  P  +      +AE +R+ +   PFT     + +TVS GV   RA      
Sbjct: 382 WGGEEFLILNPETSLDGARTLAEHLRRLIRRTPFTVD--KIDVTVSFGVTDYRA-----G 434

Query: 281 DDFNKLMVEADTCLYRSKKDGRNRTSTM 308
           +D   ++  AD+ LY++K+ GR++T   
Sbjct: 435 EDIETMIQRADSALYQAKQSGRDKTVVF 462


>UniRef50_Q085X7 Diguanylate cyclase n=2 Tax=Alteromonadales RepID=Q085X7_SHEFN
          Length = 357

 Score =  233 bits (594), Expect = 7e-60,   Method: Composition-based stats.
 Identities = 81/317 (25%), Positives = 139/317 (43%), Gaps = 34/317 (10%)

Query: 11  STGVLIVPCM-------LTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPL 63
           S  VL +          L   +     +      +   +L + +   V  GG        
Sbjct: 43  SNNVLTITLFVSSIIYCLAYIVLKKYNKLNLSSFIIIYSLYILMFYLVFTGGVEQ----- 97

Query: 64  PALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQM------FSARLG 117
              +W  +     V  L   ++  +  +L   S+I I + SP  +PQ       F  RL 
Sbjct: 98  TGPLWIFIVAPVSVYVL--GLSYGLVNLLFFLSIIAIIMFSPIEMPQYATYSTEFKVRLI 155

Query: 118 IATMAICPIMVSFSVAAINSLM------KQVALRADFDFLTQVYSRS---GLYEALKSPS 168
           ++ +    +   +  + + S        K+    A  D LT + +R     + +  KS  
Sbjct: 156 LSFLTTTFLSALYEYSRMLSYNSALKLGKKYQQLALSDPLTTLANRRNALTILQQEKSRI 215

Query: 169 LKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAV 228
            +  + L+V+L D+D+FK +ND YGH CGD VL+  ++  ++ V  +  VAR GGEEF  
Sbjct: 216 SRNNEPLSVLLCDLDHFKMVNDKYGHNCGDMVLTELSQVFKQSVRQQDCVARWGGEEFLF 275

Query: 229 AVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMV 288
            +P  +     ++AEKIR  V      + +  + LT+SIG+       LT   + ++L+ 
Sbjct: 276 ILPQTSAEQASVIAEKIRTNVHHHKVHFLKHEISLTISIGISQ-----LTDDQNIDELIN 330

Query: 289 EADTCLYRSKKDGRNRT 305
            AD  LY++KK+GRN+ 
Sbjct: 331 NADRNLYQAKKNGRNQV 347


>UniRef50_C4XPG9 GGDEF domain protein n=1 Tax=Desulfovibrio magneticus RS-1
           RepID=C4XPG9_DESMR
          Length = 368

 Score =  233 bits (594), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 57/190 (30%), Positives = 98/190 (51%), Gaps = 6/190 (3%)

Query: 126 IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYE---ALKSPSLKQTQHLTVMLLDI 182
           + ++  ++A  +L +++   A  D LT + +R G +E    +   + +    L++++LDI
Sbjct: 176 VGMTQDISARKALEEELLRLAASDPLTGLANRRGFFEGAARMLGMARRCGTPLSMIMLDI 235

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           D+FK++ND YGH+ GD VL   A  +++ +    L  R+GGEEFAV  P  +   G+ +A
Sbjct: 236 DHFKAVNDAYGHDAGDAVLRAVAGRLRESLRVSDLAGRVGGEEFAVLCPGTDLAGGVELA 295

Query: 243 EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           E++R  +E    T   + + +T S GV   R          +  +  AD  LY +K+ GR
Sbjct: 296 ERLRLALEDMVVTADCRAVKVTASFGVAQCRDDRDAAP---SACLTRADRALYAAKRGGR 352

Query: 303 NRTSTMRYGE 312
           NR      G 
Sbjct: 353 NRVCLESDGS 362


>UniRef50_Q0A9X2 Diguanylate cyclase n=3 Tax=Proteobacteria RepID=Q0A9X2_ALHEH
          Length = 295

 Score =  233 bits (594), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 64/187 (34%), Positives = 103/187 (55%), Gaps = 8/187 (4%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ----HLTVMLLDIDYFK 186
            V A  +L +++   A  D LT VYSR  + E  +    ++ +     LT++++D+D+FK
Sbjct: 109 EVQARETLAEELHRLAMMDDLTGVYSRRQVLEVGERELARRRRQGLTPLTLLMMDLDHFK 168

Query: 187 SINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIR 246
            IND YGH  GD VL  F+  +++ + +   V R+GGEEF   +P V+   GL +AE+IR
Sbjct: 169 RINDKYGHAAGDTVLVAFSEVLRRNLRESDAVGRLGGEEFLAVLPDVDLQGGLALAERIR 228

Query: 247 KGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
             +      WQ++ + LTVSIGV    A +    +  +  ++ AD  LY++K  GRNR +
Sbjct: 229 SEIAELRIPWQEEAIRLTVSIGVAGILAVH----ESLDDTIMRADDALYQAKVAGRNRVT 284

Query: 307 TMRYGEE 313
               G +
Sbjct: 285 VAGSGAQ 291


>UniRef50_A8TM57 Putative diguanylate cyclase (GGDEF domain) with PAS/PAC sensor
           domain n=1 Tax=alpha proteobacterium BAL199
           RepID=A8TM57_9PROT
          Length = 461

 Score =  233 bits (594), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 56/190 (29%), Positives = 92/190 (48%), Gaps = 7/190 (3%)

Query: 123 ICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVML 179
           I    V   V   + L +++   A  D LT + +R       +     +++  + ++V++
Sbjct: 274 IGVTGVMVDVTESHRLRQELERLATTDPLTGLSNRRAFLMRAREEVERAVRHDRPMSVVM 333

Query: 180 LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDK-GLVARMGGEEFAVAVPSVNPVDG 238
           +D+D+FKS+ND YGH+ GD VL   A  +Q  + +   + AR GGEEF + +P       
Sbjct: 334 IDVDHFKSVNDRYGHDIGDLVLQDVAATVQGALRNSGDVAARFGGEEFVLLLPETTVSGA 393

Query: 239 LLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSK 298
             +AE+IR   E      +Q  +  T S GV   R+   T     + ++  AD  LYR+K
Sbjct: 394 QQLAERIRVAFERTAVETEQGAVRFTASFGVDVFRSDMDTG---IDTVLKRADDALYRAK 450

Query: 299 KDGRNRTSTM 308
           + GRNR    
Sbjct: 451 EAGRNRVQLA 460


>UniRef50_D1TF13 Response regulator receiver protein n=1 Tax=Burkholderia sp.
           CCGE1002 RepID=D1TF13_9BURK
          Length = 531

 Score =  233 bits (594), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 76/243 (31%), Positives = 118/243 (48%), Gaps = 11/243 (4%)

Query: 78  TCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPI---MVSFSVAA 134
                 V G   IV +A +V D+   +P+      +A L IA  A+  +   +++F++  
Sbjct: 278 IFTYAHVPGTPLIVAIAPAVDDVL--APWQRRSHVAAALTIAFGAVFVVVSWLLAFALRD 335

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDN 191
                  +   A  D LT + +R  L + L      + +  + L+V+ +DID+FK  ND 
Sbjct: 336 KQRAQAALLRLASTDPLTGLSNRRVLDKRLDDEWMRARRDNRPLSVLFIDIDHFKRFNDT 395

Query: 192 YGHECGDKVLSVFARHIQKIVGDK-GLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVE 250
           YGHE GD+VL   A  I  +      LVAR GGEEFAV +P         +AE+IR+ VE
Sbjct: 396 YGHESGDEVLVAVADCIASVARRSVDLVARYGGEEFAVVLPDTTAQGAFAVAEQIRRKVE 455

Query: 251 LQPFTWQQK-TLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
            +      +    +TVS+G  + R S     +    L+  AD  LY +K +GRNRT + +
Sbjct: 456 SRVIVRGHEAPQAVTVSVGCATARPSTADFANGLE-LLAAADAQLYVAKNEGRNRTRSAQ 514

Query: 310 YGE 312
           + E
Sbjct: 515 WDE 517


>UniRef50_Q30WV4 Diguanylate cyclase (GGDEF domain) with PAS/PAC sensor n=1
           Tax=Desulfovibrio desulfuricans subsp. desulfuricans
           str. G20 RepID=Q30WV4_DESDG
          Length = 398

 Score =  233 bits (594), Expect = 9e-60,   Method: Composition-based stats.
 Identities = 55/204 (26%), Positives = 98/204 (48%), Gaps = 21/204 (10%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLK---QTQHLTVMLL 180
             + V   V A   ++++++  A  D LT + +R    EA ++   +     + L++++L
Sbjct: 183 THVGVVLDVTAHRRMLEELSHMARTDPLTGLNNRRFFMEAARAEVERMQSSGRPLSLLML 242

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DID+FK +ND +GH+ GD VL   +  + + +  + + AR+GGEEFAV +P     +   
Sbjct: 243 DIDHFKRVNDTWGHDAGDMVLKQLSCCLAETMRGQDVCARLGGEEFAVLLPETGHAEACR 302

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDD----------------FN 284
            AE +R+ V    F        +T S+G+ +  ++   ++                    
Sbjct: 303 AAETLRQAVAGMAFA--GHGFSVTSSLGLTTLDSAGHAVSGQRPVPGGVAVSACCGQVVE 360

Query: 285 KLMVEADTCLYRSKKDGRNRTSTM 308
            L+  AD  LY +KK+GRNRT   
Sbjct: 361 ILLKRADIALYAAKKNGRNRTEVY 384


>UniRef50_A4BIU7 Response regulator containing a CheY-like receiver domain and a
           GGDEF domain n=1 Tax=Reinekea blandensis MED297
           RepID=A4BIU7_9GAMM
          Length = 318

 Score =  233 bits (594), Expect = 9e-60,   Method: Composition-based stats.
 Identities = 60/194 (30%), Positives = 106/194 (54%), Gaps = 7/194 (3%)

Query: 117 GIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH-- 174
            +A +      ++ S   + +   ++A  +  D LTQ+Y+R+   E L +   +Q +H  
Sbjct: 127 NLAVIVYDVTDIATSKLELKAANDRLAQLSRTDGLTQLYNRAYWEEMLSNEFKRQKRHAH 186

Query: 175 -LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSV 233
            L++++ DID+FK +ND YGH+ GD V+   A  ++    +  +  R GGEEFA+ +   
Sbjct: 187 DLSLIMFDIDHFKKVNDTYGHQVGDDVIRAVAEEVRHNSRNTDIAGRYGGEEFALLLIDS 246

Query: 234 NPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTC 293
           +  + LL AE++RK +E +  +  +  L +TVS+GV   + S+      +N  +  AD  
Sbjct: 247 DAENALLFAERLRKAIENRRVSTPEGELQVTVSLGVAPWKESF----HHYNAWIEAADKA 302

Query: 294 LYRSKKDGRNRTST 307
           LY SK +GRNR++ 
Sbjct: 303 LYTSKDEGRNRSTL 316


>UniRef50_Q0EXC8 Signal transduction protein containing a membrane domain an EAL and
           a GGDEF domain-like n=1 Tax=Mariprofundus ferrooxydans
           PV-1 RepID=Q0EXC8_9PROT
          Length = 615

 Score =  233 bits (594), Expect = 9e-60,   Method: Composition-based stats.
 Identities = 53/184 (28%), Positives = 94/184 (51%), Gaps = 9/184 (4%)

Query: 128 VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDY 184
           +   +     L +++  +A  D LT + +R   +E  +    +  +H    ++++LD+D+
Sbjct: 431 IDRDITDRKELERELESQARTDVLTGLNNRRYFFELAELELARAKRHGNQFSLLMLDVDH 490

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEK 244
           FK  ND+YGH  GD+VL   +      + +  L  R+GGEEFA+ +P       + +AE+
Sbjct: 491 FKLFNDSYGHHIGDRVLQKLSEVCMHTLREIDLSGRIGGEEFAIMLPETRGDRAMEVAER 550

Query: 245 IRKGVELQPFTWQQKT--LYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           +R  +   P   +Q++  ++ TVSIGV S  A+        + L+  AD  LY +K  GR
Sbjct: 551 LRLAIAGAPVLLEQQSTFVHFTVSIGVTSLVAAGRQ----VDDLLKRADDALYAAKNAGR 606

Query: 303 NRTS 306
           N+  
Sbjct: 607 NQVC 610


>UniRef50_A7N081 Putative uncharacterized protein n=6 Tax=Vibrio RepID=A7N081_VIBHB
          Length = 354

 Score =  232 bits (593), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 61/192 (31%), Positives = 97/192 (50%), Gaps = 8/192 (4%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPS---LKQTQHLTVMLL 180
             I     V   + L K++   ++ D LT V +R      L       L+ +Q L+ +++
Sbjct: 150 WVIWSVRDVTKTHLLEKRLKELSETDELTGVLNRRAFLTRLDKAMSSHLRPSQTLSCIMI 209

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DID+FK IND  GH  GD+V+   A+  Q+ +     + R+GGEEFAV + + + +    
Sbjct: 210 DIDHFKEINDQVGHFSGDQVIHHVAKICQRAIRGSDFIGRLGGEEFAVILVNTSAIQAYD 269

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           +AE+IR+ ++  P       +  TVSIGV        + T+    LMV AD  +Y SK  
Sbjct: 270 VAERIREAIQNAPCKVDGIEISTTVSIGVAEYDEQVSSTTE----LMVNADKAMYYSKHS 325

Query: 301 GRNRTSTMRYGE 312
           GRN+  T+ +G 
Sbjct: 326 GRNQV-TLHHGS 336


>UniRef50_A3DHG2 Diguanylate cyclase with GAF sensor n=3 Tax=Clostridium
           thermocellum RepID=A3DHG2_CLOTH
          Length = 415

 Score =  232 bits (593), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 68/194 (35%), Positives = 102/194 (52%), Gaps = 9/194 (4%)

Query: 126 IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSL---KQTQHLTVMLLDI 182
           I V+  V +    + Q+   A  D LT++Y+R  L + L +         Q L+V+++DI
Sbjct: 226 IEVAKPVISSKRTLHQLRKNATTDKLTKLYNRRFLEQYLDNQLEITGFSNQKLSVIMMDI 285

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           D FK IND YGH  GD VL  FAR I + +    LVAR GGEEF   +PS +  +   +A
Sbjct: 286 DNFKRINDTYGHNAGDAVLVTFARVILRCLRQTDLVARYGGEEFIAILPSSDTKNAYDIA 345

Query: 243 EKIRKGVELQPFT--WQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           E+IR+ +  +P       +   ++ S GV +    Y T   + N L+  AD  LY++K+ 
Sbjct: 346 ERIRESIAAEPMPKINDVQLPNISCSFGVST----YPTHAKNKNDLIKAADIALYKAKQA 401

Query: 301 GRNRTSTMRYGEEV 314
           G+NR  T   G E+
Sbjct: 402 GKNRVITYSEGMEM 415


>UniRef50_B8DIJ3 Diguanylate cyclase with PAS/PAC and GAF sensors n=1
           Tax=Desulfovibrio vulgaris str. 'Miyazaki F'
           RepID=B8DIJ3_DESVM
          Length = 1000

 Score =  232 bits (592), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 53/189 (28%), Positives = 92/189 (48%), Gaps = 7/189 (3%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVMLL 180
             + ++  +     L + +   A  D LT + +R   +   E     +++  + L V++L
Sbjct: 793 VVLSIARDITDRKRLEQALMREATTDPLTGIRNRRQFFVDAEREMGRAVRYGRPLAVLML 852

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           D+D FK +ND +GH  GD VL    +  Q+ + +  ++ R+GGEEFA  +   +  D L 
Sbjct: 853 DLDRFKRVNDRFGHHAGDAVLMGCVQACQQALRETDILGRLGGEEFAAVLLETDLDDALA 912

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
            AE++R+ VE     +  + L  TVSIG+              + ++  AD+ LY +K+ 
Sbjct: 913 AAERLRRAVEEMDVPFSGQRLRCTVSIGLALRGPG----DGALDDILRRADSALYAAKEA 968

Query: 301 GRNRTSTMR 309
           GRNR    R
Sbjct: 969 GRNRVMLAR 977


>UniRef50_C5T8F5 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Acidovorax
            delafieldii 2AN RepID=C5T8F5_ACIDE
          Length = 1152

 Score =  232 bits (592), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 56/194 (28%), Positives = 95/194 (48%), Gaps = 12/194 (6%)

Query: 126  IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQ---TQHLTVMLLDI 182
            + ++  V       + +   A  D LT + +R      L+   ++     +   +++LD+
Sbjct: 961  LWIAKDVTERRRHEQTLERLATTDALTGLANRRAFMARLEEERMRPSMGGRGGMLIMLDL 1020

Query: 183  DYFKSINDNYGHECGDKVLSVFARHIQ-KIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
            D+FK +ND +GH  GD+VL   AR ++  ++    L  R+GGEEFAV +P     + L +
Sbjct: 1021 DHFKRVNDTWGHAAGDEVLVHLARLLRGDLLRATDLAGRLGGEEFAVLLPDTTAEEALGV 1080

Query: 242  AEKIRKGVELQPFTW-QQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
            AE++R+ +E          TL +T+S+GV         +T D   ++  AD  LY +K  
Sbjct: 1081 AERLRRALEQSKIHVGDGATLQVTMSLGVA-------PITGDALAVLAHADIALYEAKNT 1133

Query: 301  GRNRTSTMRYGEEV 314
            GRN+    R  E V
Sbjct: 1134 GRNKVVLARSDEPV 1147


>UniRef50_A8UY29 Putative uncharacterized protein n=1 Tax=Hydrogenivirga sp.
           128-5-R1-1 RepID=A8UY29_9AQUI
          Length = 336

 Score =  232 bits (592), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 59/194 (30%), Positives = 98/194 (50%), Gaps = 8/194 (4%)

Query: 122 AICPIMVSFSVAAINSLMKQ-VALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTV 177
            +  +   FS      L K+ +  +A  D LT +Y+R  L EA      +  +    +++
Sbjct: 146 ILRSLAFIFSFIVKEELEKKRLLEKAIIDHLTGLYNRFYLEEAGAREIARAKRYGFPISL 205

Query: 178 MLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVD 237
           ++ D+D FK +ND YGH+ GD+VL  FA  +   V    +  R GGEEF V +P   P +
Sbjct: 206 IMFDLDNFKQVNDTYGHQVGDRVLVKFASIVSSNVRSTDMPVRYGGEEFVVLLPHTYPEE 265

Query: 238 GLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRS 297
            + +AE+IR+  E   F ++ + + LTVS G+    +   +L +    L+  AD  +Y +
Sbjct: 266 AVKVAERIREEFEKFLFRFEGEVMRLTVSAGISFCNSGECSLGE----LIQMADKAMYEA 321

Query: 298 KKDGRNRTSTMRYG 311
           K+ G+NR     Y 
Sbjct: 322 KEKGKNRIEVFSYQ 335


>UniRef50_Q5NP17 Diguanylate cyclase with beta propeller sensor n=3 Tax=Zymomonas
            mobilis RepID=Q5NP17_ZYMMO
          Length = 1008

 Score =  232 bits (592), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 57/185 (30%), Positives = 94/185 (50%), Gaps = 8/185 (4%)

Query: 126  IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDI 182
            +M++     +     ++   A+ D LT + +R    E  +    + ++     +V +LDI
Sbjct: 829  LMITNKTLELQETNLRLKELANTDELTGLLNRRAFTEMFEKNCAQFSKTKDQFSVFILDI 888

Query: 183  DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
            D+FK INDN GH  GD V+   A+ I + +  +   AR GGEEF + +P+ +      +A
Sbjct: 889  DFFKKINDNEGHLAGDAVIQYIAQKITENIRQQDFAARYGGEEFVIMLPNADMETTCQVA 948

Query: 243  EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
             +I   +  +P  +Q + + +TVSIGV       +   DD N L+  AD  LY +K  GR
Sbjct: 949  SRIGNAISEKPVPYQGREIPVTVSIGVA-----VMKENDDANSLLERADERLYMAKNQGR 1003

Query: 303  NRTST 307
            NR S+
Sbjct: 1004 NRVSS 1008


>UniRef50_C6NZP2 Periplasmic/7TM domain sensor diguanylate cyclase n=1
           Tax=Sideroxydans lithotrophicus ES-1 RepID=C6NZP2_9PROT
          Length = 570

 Score =  232 bits (592), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 72/310 (23%), Positives = 138/310 (44%), Gaps = 23/310 (7%)

Query: 13  GVLIVPCMLTL------AIPGVLPRFKAEQMMPAIALIV-SVIASVVIGGAGSLAFPLPA 65
           G++     L L       + G+        ++ A+AL+V S   + ++    + AF +  
Sbjct: 265 GLMFAARFLALKKHSPRTLRGIRWIGTLAVVIMALALMVDSQFVAAMVAFVCTTAFTIGM 324

Query: 66  LIWCAVRYTPQVTC----LLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATM 121
            +   +      T     L     G + + + A +V       P++     +A  G+   
Sbjct: 325 FLLGILSVLRNQTSGRYFLFATFFGMLGVGVTALAVWGKIPFRPYTFH---AAEFGLVIE 381

Query: 122 A-ICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEAL---KSPSLKQTQHLTV 177
           A +  + +S  +      + +    A  D LT + +R    E      S + +  + +++
Sbjct: 382 ATLLALGLSNWMRENRDALYEAEQVARLDALTHLNNRRAFMELALPYASTAGRHERPMSL 441

Query: 178 MLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVD 237
           +++DID+FKSIND YGH+ GD VL+  A  ++       +VAR GGEEF + +P      
Sbjct: 442 VMMDIDHFKSINDQYGHQTGDLVLTAVADLLKNFSRTSDIVARWGGEEFILLLPETGLKQ 501

Query: 238 GLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRS 297
            +  AE++R+ +        + ++ LT S G+ +  A+       F+K++ +AD  LY +
Sbjct: 502 AINHAERLRQAIAEFRIPVGETSISLTASFGIAAHVANL-----SFDKMIEQADVQLYEA 556

Query: 298 KKDGRNRTST 307
           K+ GRN+   
Sbjct: 557 KRSGRNKVCC 566


>UniRef50_Q1MZ89 Response regulator containing a CheY-like receiver domain and a
           GGDEF domain n=2 Tax=Gammaproteobacteria
           RepID=Q1MZ89_9GAMM
          Length = 577

 Score =  232 bits (592), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 60/177 (33%), Positives = 97/177 (54%), Gaps = 8/177 (4%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKS 187
            +      + Q  L+A  D LT + +R       +    +  ++   L++++ D+D FKS
Sbjct: 383 ELEEAKEQLNQSQLKAMTDSLTGLPNRGAYDVYAQQEYERYKRYGGELSLIVCDVDKFKS 442

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           IND YGH+ GDKVL + +R ++K   +  L+AR GGEEF V +P     D + +AEKI +
Sbjct: 443 INDTYGHQAGDKVLQLISRQVKKGTRETDLLARYGGEEFVVLLPETKQEDAVSVAEKIIE 502

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
            V   PF ++ K + +T+S GV S +  Y        ++   AD  LYR+K++GRN+
Sbjct: 503 AVATSPFHFRGKRVQITISCGVASFKKGYRP-----EQVFDAADAALYRAKENGRNQ 554


>UniRef50_Q1ZGY5 GGDEF domain protein n=1 Tax=Psychromonas sp. CNPT3
           RepID=Q1ZGY5_9GAMM
          Length = 493

 Score =  231 bits (591), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 56/188 (29%), Positives = 99/188 (52%), Gaps = 8/188 (4%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKS 187
                   +KQ +  A  DFLT++ +R    E L    S   +    L + ++D+D+FK 
Sbjct: 307 ETQNYQKTLKQQSELAHLDFLTKIPNREAWSERLTFEFSRYQRYQNPLKIAIIDMDHFKR 366

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           IND +GH  GDKV++V A+ ++K + +   +AR GGEEFA+ +P +     + + +K+  
Sbjct: 367 INDQFGHLAGDKVINVVAQTLKKSLRNTDFIARYGGEEFAILLPEITNEQAVDVLQKLCA 426

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
            +   PF +++  + +T+SIG  S         D+ +     AD  LY++K  GRN+   
Sbjct: 427 KIASIPFKFKKDNISITISIGCASF-----DKGDNIDSAFERADNALYKAKNGGRNQVVF 481

Query: 308 MRYGEEVV 315
             +G+E++
Sbjct: 482 FAHGDELL 489


>UniRef50_A4BG19 GGDEF domain protein n=1 Tax=Reinekea blandensis MED297
           RepID=A4BG19_9GAMM
          Length = 377

 Score =  231 bits (591), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 82/304 (26%), Positives = 131/304 (43%), Gaps = 13/304 (4%)

Query: 10  FSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAG----SLAFPLPA 65
           F+   L +   + L I      F     +  + L V  +  V  GGA        + LP 
Sbjct: 66  FTAFALFLFAHIQLRIKRNQSAFLFAARLVQLVLFVLCLYLVYAGGANQTGPLWVYLLPP 125

Query: 66  LIWCAVRYTPQVTCLLTFVTGAVEIVLV-ANSVIDISVGSPFSIPQMFSARLGIATMAIC 124
           ++         +     FV G + IV    N++  +     F    ++S        A+ 
Sbjct: 126 VVMFLSGLKRGMMITALFVLGYLIIVFFPGNALGAVDYSYEFKTRLLYSFLTLTFLAAVY 185

Query: 125 PIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLD 181
                 S   +N L +    +A  D LT + +R G+ E ++     S +  Q +T +L D
Sbjct: 186 EQSRQSSYQKLNELKQDFERQASQDTLTHLLNRRGMRERIRYEVRRSQRNNQPITFILAD 245

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           +D+FK IND+YGH+ GD VL   ++ +Q  V  +  +AR GGEEF   +P  N    + +
Sbjct: 246 LDHFKEINDHYGHDTGDTVLIQVSQLLQDSVRQQDSIARWGGEEFLFLLPETNARQAMQL 305

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
           AEKIR  +E  P    Q  L  T+S G+       +   ++    + EAD  LY++K  G
Sbjct: 306 AEKIRSIIESHPLNSDQPPLTTTMSFGIAE-----MLDLENHQSTIAEADNRLYQAKSQG 360

Query: 302 RNRT 305
           RN  
Sbjct: 361 RNCV 364


>UniRef50_A9FZW1 FHA domain protein n=1 Tax=Sorangium cellulosum 'So ce 56'
           RepID=A9FZW1_SORC5
          Length = 299

 Score =  231 bits (591), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 59/174 (33%), Positives = 92/174 (52%), Gaps = 7/174 (4%)

Query: 137 SLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYG 193
              +++      D LTQ++++  LYEAL+   ++  +H   L ++L DID+FK IND +G
Sbjct: 130 QYHEEIYRMTIIDGLTQIHNKRYLYEALEREIIRGRRHERDLAILLFDIDHFKRINDVHG 189

Query: 194 HECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP 253
           H  GD VL   AR +Q  +    + AR GGEEFA+ +P  +      + E +R+ V    
Sbjct: 190 HLAGDFVLKEVARIVQSRIRRDEVFARYGGEEFAIILPETSIEGAAALGETLRQKVAEHL 249

Query: 254 FTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
           F +Q  ++ +T+S+GV   +    T  D    L+  AD  LY +K  GRNR   
Sbjct: 250 FVFQADSIRVTISVGVALLQEGDRTAND----LIKRADERLYHAKNSGRNRVCA 299


>UniRef50_A4C957 Putative uncharacterized protein n=1 Tax=Pseudoalteromonas tunicata
           D2 RepID=A4C957_9GAMM
          Length = 639

 Score =  231 bits (591), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 68/227 (29%), Positives = 112/227 (49%), Gaps = 10/227 (4%)

Query: 85  TGAVEIVLVANSVID-ISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVA 143
           T     +L  +S+ID +++       QM   +L  +  A   I++S  V     + K++ 
Sbjct: 416 TELQNKLLQQSSLIDQLALEKAKQTEQM--QKLVNSLFAAILILLSVFVYRQVKVSKRLN 473

Query: 144 LRADFDFLTQVYSRSG---LYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKV 200
             A+ D LTQ+ +R       + +   +  + + L++++ DID+FK INDNYGH  GD+V
Sbjct: 474 RLANTDSLTQLANRRYTFHFAKIVFKEAQIEQKPLSIIIFDIDHFKRINDNYGHPFGDEV 533

Query: 201 LSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKT 260
           L   A   Q  + +  L+ R+GGEEF V + +      + +AE++R+ +    F   Q+ 
Sbjct: 534 LMAVADKAQAGLREPDLLGRIGGEEFMVVLKNTPINQAVEIAERMRELIAQLSFAAAQQQ 593

Query: 261 LYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
           + +T S GV           DDF  L   AD  LYR+K  GRN+   
Sbjct: 594 VKVTASFGVAQFN----VDVDDFGSLFQHADEALYRAKNAGRNQVVC 636


>UniRef50_Q2VYV6 FOG: GGDEF domain n=2 Tax=Magnetospirillum RepID=Q2VYV6_MAGSA
          Length = 578

 Score =  231 bits (591), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 53/185 (28%), Positives = 90/185 (48%), Gaps = 7/185 (3%)

Query: 126 IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDI 182
           I V   +     +  ++   A  D LT +++R    E  +     + +  + L  ++LDI
Sbjct: 397 IGVMLDITERKRMEAELRRLATTDVLTGIFNRRHFMEMARIEVDRARRHGRPLVALMLDI 456

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           D+FK IND +GH  GD  +   A    +I+  + ++ RMGGEEFA+ +   +    LL+A
Sbjct: 457 DHFKRINDTHGHPVGDVAIKALADVCTQIIRHEDVLGRMGGEEFAIVLTETDLDGALLVA 516

Query: 243 EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           E++R+ V       +  T+  T SIGV       L      + ++  AD  LY +K+ GR
Sbjct: 517 ERLRQAVAAIRIPAELGTVAFTTSIGVAER----LEGDATIDTILSRADMALYSAKRSGR 572

Query: 303 NRTST 307
           N+ + 
Sbjct: 573 NKVAV 577


>UniRef50_Q07MN8 Diguanylate cyclase n=10 Tax=Bradyrhizobiaceae RepID=Q07MN8_RHOP5
          Length = 418

 Score =  231 bits (591), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 93/299 (31%), Positives = 137/299 (45%), Gaps = 47/299 (15%)

Query: 13  GVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVR 72
           G++ +  +LT A  G   R   ++  PAI      I  ++ GG   L   L  L+    +
Sbjct: 123 GIVAIYAVLTAAELGSERRKSMQRRWPAI------IVPLLHGGVLMLPILLSDLLTPPAQ 176

Query: 73  YTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSV 132
            T     L+ F   AVE+VL A       VG+ F+I  + S R                 
Sbjct: 177 TTAGNVWLMVF---AVELVLYA-------VGTVFAIFMLVSER----------------- 209

Query: 133 AAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQ---TQHLTVMLLDIDYFKSIN 189
                 ++     A  D LT +++R G  EA      ++    + +TVM+ DIDYFKSIN
Sbjct: 210 -----TVRAHKTAASIDPLTGLFNRRGFTEATTRMIEREAAAGRPVTVMIFDIDYFKSIN 264

Query: 190 DNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGV 249
           D +GH  GD++L +FA  I   +    L  R+GGEEFA  +P  +  + L+ AE++R   
Sbjct: 265 DRFGHPAGDELLKLFATLITSSLRITDLSGRIGGEEFAALLP-CSIDEALVAAERVRWSF 323

Query: 250 ELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
           E          +  TVSIGV  G A       + + L+  ADT LY++K+ GRNR  T 
Sbjct: 324 ETCGIVVDNDPVATTVSIGVAGGPA-----RTELDVLLAAADTALYQAKRGGRNRVETA 377


>UniRef50_A3Y5H4 Diguanylate cyclase (GGDEF domain) n=1 Tax=Marinomonas sp. MED121
           RepID=A3Y5H4_9GAMM
          Length = 419

 Score =  231 bits (591), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 59/203 (29%), Positives = 98/203 (48%), Gaps = 6/203 (2%)

Query: 111 MFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLK 170
           +  + + I T  +  I              ++   A  D LT +Y+R      L     +
Sbjct: 197 LLLSSIAIITAFVIGIGYKKVQQIREEYELELIEMATKDKLTNIYNRRSFEARLLQDLKQ 256

Query: 171 QTQ---HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFA 227
             +    L+++L D+D+FK +ND YGH+ GD VL++ A   Q+ V    +VAR GGEEF 
Sbjct: 257 YDKFQTELSIILFDVDHFKFVNDTYGHQAGDSVLTLLAEIAQQTVRSNDIVARYGGEEFI 316

Query: 228 VAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLM 287
           + +P+       ++AEK+R  +E   F  Q   + +T+S+GV            + + L+
Sbjct: 317 ILLPNTGKNGSQVIAEKLRSAIENAAFDTQSYKIQITISLGVACISDVQHP---NLDNLI 373

Query: 288 VEADTCLYRSKKDGRNRTSTMRY 310
             AD  LY +K +GRN+ S M+ 
Sbjct: 374 KSADDALYYAKHNGRNQVSYMQT 396


>UniRef50_Q31IP8 Diguanylate cyclase (GGDEF domain) with PAS/PAC sensor n=1
           Tax=Thiomicrospira crunogena XCL-2 RepID=Q31IP8_THICR
          Length = 540

 Score =  231 bits (591), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 53/186 (28%), Positives = 100/186 (53%), Gaps = 6/186 (3%)

Query: 132 VAAINSLMKQVALRADFDFLTQVYSRSGLYEALKS---PSLKQTQHLTVMLLDIDYFKSI 188
           +  + SL+ Q+   A  D+LT + +R   +E  +     + +  Q ++++++DID+FK I
Sbjct: 358 MEQLGSLLNQLRDEATKDYLTGLLNRKAFFEQAEQIWLSAKEHHQPISLLMIDIDHFKRI 417

Query: 189 NDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKG 248
           ND++GH+ GD+VL   A    +   ++ LV R GGEEF + + + +    L  A +++K 
Sbjct: 418 NDSFGHDAGDRVLIEVANVFSQNCREEDLVCRYGGEEFIILLENKDEQPTLEFASRLKKV 477

Query: 249 VELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
           ++    + Q + +  ++S+GV +G A  L   +     +  AD  LY++K +GRNR    
Sbjct: 478 IQEMSVSEQGEVIRFSISVGVATGSALEL---NSIETFISHADQALYQAKANGRNRVEVF 534

Query: 309 RYGEEV 314
              E+ 
Sbjct: 535 HAEEKT 540


>UniRef50_Q1JXK3 Diguanylate cyclase n=1 Tax=Desulfuromonas acetoxidans DSM 684
           RepID=Q1JXK3_DESAC
          Length = 475

 Score =  231 bits (591), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 62/221 (28%), Positives = 105/221 (47%), Gaps = 11/221 (4%)

Query: 91  VLVANSVIDISVGSPFSIPQMFSARLGIATMAIC---PIMVSFSVAAINSLMKQVALRAD 147
           ++ A S+ + +  + +    +     G+   AI     I+   S      + +Q+  +A 
Sbjct: 254 MIAAVSINEDNFFADWRRHSLLMGGFGLVVGAILFTLSILTVRSQQEQFRIQQQLQQQAT 313

Query: 148 FDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGHECGDKVLSVF 204
            D LT + +R    E       +  +    L+V+++DID+FK +ND YGH  GD+VL   
Sbjct: 314 TDPLTGIANRRYALEQAALEIKRNQRTGTPLSVVMMDIDHFKKVNDTYGHHVGDQVLMEV 373

Query: 205 ARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLT 264
           A+  +    +  LV+R GGEEF + +PS N       AEKIR+ +E   F   +  + +T
Sbjct: 374 AQTCRSHCRESDLVSRFGGEEFLILLPSTNLNGAQTHAEKIRQAIEDLSFPTAEGNVSVT 433

Query: 265 VSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
            S GV   +          ++++  AD  LY++K DGRN  
Sbjct: 434 ASFGVSQWQGETK-----IDRVVSRADAALYQAKHDGRNCV 469


>UniRef50_Q47C76 PAS:GGDEF n=1 Tax=Dechloromonas aromatica RCB RepID=Q47C76_DECAR
          Length = 548

 Score =  231 bits (590), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 69/211 (32%), Positives = 107/211 (50%), Gaps = 11/211 (5%)

Query: 103 GSPFSIPQMFSARLGIATMA-ICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY 161
           G  F +   F  R     +  IC I  S  +  I    K++   + FD LT +++R   +
Sbjct: 338 GEAFFLSVKFPTRNSSNEITGICGI--STDITPIKHYQKELERLSQFDELTNLFNRRHFF 395

Query: 162 EALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLV 218
              K    + +++   L+VM+LDID+FK IND +GH+ GD VL+   + I   + D  + 
Sbjct: 396 SLAKHELNRSSRYRSKLSVMMLDIDHFKRINDGHGHKTGDLVLANIGKQIGDSLRDSDIA 455

Query: 219 ARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTW-QQKTLYLTVSIGVGSGRASYL 277
            RMGGEEFA+ +P  +     +MAE++RK V          +TL  T+SIG+ +     +
Sbjct: 456 GRMGGEEFAILLPETDLEQASIMAERLRKQVAETWLDIGDGRTLNCTLSIGLATKSDQQI 515

Query: 278 TLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
               D   L+ +ADT LY +K  GRN+ S  
Sbjct: 516 ----DLENLLHQADTALYAAKNSGRNKVSCA 542


>UniRef50_B5JSY0 Response regulator PleD n=1 Tax=gamma proteobacterium HTCC5015
           RepID=B5JSY0_9GAMM
          Length = 261

 Score =  231 bits (590), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 69/236 (29%), Positives = 112/236 (47%), Gaps = 11/236 (4%)

Query: 74  TPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVA 133
               T L+T V     +      ++               A L I      P++ +   +
Sbjct: 11  NVATTLLMTAVVSGSTVCCALGLILLGFPIGGKVWNFAVPAALIIPFFVGTPLVHNLIKS 70

Query: 134 AIN--SLMKQVALRADFDFLTQVYSRSGLYEAL---KSPSLKQTQHLTVMLLDIDYFKSI 188
            I    + KQ+   A+ D LT +Y+R   ++          + + H ++++LD+D+FKSI
Sbjct: 71  NIKLLRVQKQLEELANKDALTGLYNRQYFFDHANEWDKRCRENSGHFSLLMLDVDHFKSI 130

Query: 189 NDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKG 248
           ND +GH  GD+VL   +  I+  +  + + AR GGEEF   +P  N      +AE+IR G
Sbjct: 131 NDRFGHPVGDRVLQRVSNVIKGFMRQEDMCARYGGEEFICLLPDTNAAGAKAVAERIRLG 190

Query: 249 VELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           +E Q F  + + L L+VSIG     A+ ++  D+   L+  AD  LY +K  GRNR
Sbjct: 191 MEHQAF-LKARGLSLSVSIG-----ATTMSANDNLETLIERADQALYEAKDGGRNR 240


>UniRef50_A0KXZ1 Diguanylate cyclase n=4 Tax=Shewanella RepID=A0KXZ1_SHESA
          Length = 329

 Score =  231 bits (590), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 54/195 (27%), Positives = 92/195 (47%), Gaps = 11/195 (5%)

Query: 123 ICPIMVSFSVAAINSLMKQV-------ALRADFDFLTQVYSRSGLYEALKSPSLKQTQHL 175
           +  I ++  +     + + +          AD D LTQ+Y+R   +   +  + +  Q L
Sbjct: 132 LVRIEIATDITERKQMEQALIEAKSTAERLADTDELTQLYNRRAFFNLGRQIAQQTAQPL 191

Query: 176 TVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNP 235
             ++ DID+FK IND +GH  GD  L   AR  Q  +    ++AR+GGEEF + +P+ + 
Sbjct: 192 AFIMFDIDHFKRINDRWGHAMGDAALIHIARLTQTKLRTNDILARLGGEEFGLILPNTHH 251

Query: 236 VDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDD----FNKLMVEAD 291
                +AE IR G + QP      +++ T S G+ S     +   D+       L   AD
Sbjct: 252 EQAWQVAESIRHGFDTQPLQLNGHSIHCTASFGISSLVLPQINHPDEAQTLLETLFNNAD 311

Query: 292 TCLYRSKKDGRNRTS 306
             + ++K+ GRN+  
Sbjct: 312 QAMMQAKRAGRNQVC 326


>UniRef50_B9ZM04 Diguanylate cyclase n=1 Tax=Thioalkalivibrio sp. K90mix
           RepID=B9ZM04_9GAMM
          Length = 291

 Score =  231 bits (590), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 76/274 (27%), Positives = 125/274 (45%), Gaps = 16/274 (5%)

Query: 49  ASVVIGGAGSL-AFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFS 107
            ++V+G AG + A    A +   +  +   T  L          L     I ++ G   S
Sbjct: 8   GAIVLGAAGLIYAQWNLARLLRELPESRVRTGWLLMFVLIPIFTLGYLGFIPLNWGLYHS 67

Query: 108 IPQMFSARLGIATMAICPIMVSFSVAAINSLMK--QVALRADFDFLTQVYSRSGLYEALK 165
           IP +    + +   +    +V  + +++ S+ +  ++   +  D LT +++R  +   L 
Sbjct: 68  IPDLLVPIIFLLGGSFVCSVVLLTYSSVESIRRITRLEHESITDPLTGLFNRRHMDRRLD 127

Query: 166 SP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMG 222
                S +  Q L+V++LDID FK IND  GH  GD +L   A+ +++ +    L AR G
Sbjct: 128 EEVARSRRYGQPLSVVMLDIDEFKGINDRLGHLAGDYILESIAQRLRQNLRRVDLAARFG 187

Query: 223 GEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQK---------TLYLTVSIGVGSGR 273
           GEEF V  P  +    L +AEK+R  +   P   +            LY+TVS+GV S  
Sbjct: 188 GEEFVVIAPHTDQDAALQLAEKLRSEIAQTPIILKGHEHVPPCAPDELYVTVSVGVASLN 247

Query: 274 ASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
                  D+ + L+  AD  LYR+K  GRNR  +
Sbjct: 248 -IEPDSRDNADFLLQRADDALYRAKAGGRNRCES 280


>UniRef50_B7K273 Response regulator receiver modulated diguanylate cyclase n=6
           Tax=Cyanobacteria RepID=B7K273_CYAP8
          Length = 308

 Score =  231 bits (590), Expect = 3e-59,   Method: Composition-based stats.
 Identities = 63/231 (27%), Positives = 103/231 (44%), Gaps = 14/231 (6%)

Query: 78  TCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINS 137
              LT       ++          V  PF +P++ +            + +      +  
Sbjct: 85  ILFLTASNDKEHLIKAFEQGAVDYVTKPFKVPELLAR-------VKTHVELKQVQKQLQE 137

Query: 138 LMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGH 194
             + +   AD D LT + +R  L E  +     SL+      ++++D+D+FK+IND YGH
Sbjct: 138 ACQTMKKLADTDELTGIANRRCLLEFAQREFQRSLRYGTPFCLLMIDVDHFKNINDKYGH 197

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
             GDK +      I+  + +     R GGEEF V +P       L +AE+IR+ +  QP 
Sbjct: 198 PNGDKAIQWVVEIIKLGLREVDFFGRFGGEEFIVVLPQTALGGALEVAERIREAIASQPL 257

Query: 255 TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
           T +Q T+ LT SIGV +      T+      ++  AD  LY++K  GRN+ 
Sbjct: 258 TLEQDTVTLTASIGVATYTGEDKTVVG----MIQRADKSLYQAKAKGRNQV 304


>UniRef50_Q486E7 Sensory box/GGDEF domain protein n=2 Tax=Proteobacteria
           RepID=Q486E7_COLP3
          Length = 428

 Score =  231 bits (590), Expect = 3e-59,   Method: Composition-based stats.
 Identities = 66/208 (31%), Positives = 112/208 (53%), Gaps = 9/208 (4%)

Query: 103 GSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYE 162
           GS F+I    S       +    ++    ++  N L++++ L +  D LT++Y+R    E
Sbjct: 225 GSEFAIEVTISKIRIADNVEFTAVI--RDISEKNQLLEELILSSRRDPLTELYNRRYFTE 282

Query: 163 ALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVA 219
            L S    S +  +  ++++LDID+FKSIND YGH CGD  L  F++ +   + +   + 
Sbjct: 283 LLHSEITRSRRFKRGFSLLMLDIDHFKSINDRYGHACGDAALIAFSKAVTNSIREVDTIC 342

Query: 220 RMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTL 279
           R GGEEF V +P +  V  +++AEKIRK +E     ++   + +TVSIG+       + +
Sbjct: 343 RWGGEEFLVLLPEIPKVTAMVVAEKIRKNIENLETIYEGDLIKVTVSIGLEYFSGDAIEM 402

Query: 280 TDDFNKLMVEADTCLYRSKKDGRNRTST 307
           +     ++ + D  LYR+K  GRN+ ST
Sbjct: 403 S----SMINKVDQILYRAKDTGRNKIST 426


>UniRef50_A8UUF5 Diguanylate cyclase (GGDEF domain) n=1 Tax=Hydrogenivirga sp.
           128-5-R1-1 RepID=A8UUF5_9AQUI
          Length = 283

 Score =  231 bits (590), Expect = 3e-59,   Method: Composition-based stats.
 Identities = 62/177 (35%), Positives = 93/177 (52%), Gaps = 12/177 (6%)

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDN 191
           I+ L++++   AD D LT  Y+R  + E L     +  +    L+V+ +D+D FK +ND 
Sbjct: 116 ISDLIRELRFLADTDSLTGFYNRRKIEEILAKEIERSRRYGNPLSVLFIDVDNFKELNDT 175

Query: 192 YGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVEL 251
           YGH+ GD+VL   A  I+  +     V R GGEEF V +P  +    L +AE+IRK VE 
Sbjct: 176 YGHKSGDEVLRKIAEIIKSELRRTDYVGRFGGEEFMVILPETDSQSALRVAERIRKRVER 235

Query: 252 QPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
           + F        +TVS+GV       L   DD N L    D  +Y +K+ G+NR+  +
Sbjct: 236 EDFKTG----KVTVSVGVTE-----LKEGDDLNTLFNRVDRAMYLAKERGKNRSELL 283


>UniRef50_B3PIC1 Sensory box/GGDEF family protein n=5 Tax=Gammaproteobacteria
           RepID=B3PIC1_CELJU
          Length = 322

 Score =  231 bits (589), Expect = 3e-59,   Method: Composition-based stats.
 Identities = 59/193 (30%), Positives = 99/193 (51%), Gaps = 12/193 (6%)

Query: 123 ICPIMVSFSVAAINSL-----MKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---H 174
           IC I+   +  A+N +      KQ+   +  D LT +++R      L     +  +    
Sbjct: 131 ICVIIYDVTDTAVNKIAQQHANKQLQNLSRTDHLTSLFNRGYWELRLIQEFKRYDRYESP 190

Query: 175 LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVN 234
            ++++LDID+FK INDNYGH  GD+ +   +R I++ V D  +  R GGEEF + + S N
Sbjct: 191 SSLIMLDIDHFKKINDNYGHTVGDEAIRCVSRVIKEQVRDLDIAGRYGGEEFGIILTSTN 250

Query: 235 PVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCL 294
                ++AE++R  +E Q    +   ++ T+S+GV            D  + + +AD  L
Sbjct: 251 GDGACVIAERLRSIIEKQTVYAEGHEIHFTISLGVAELN----DHMHDHRQWIEKADHAL 306

Query: 295 YRSKKDGRNRTST 307
           Y+SK+ GRNR + 
Sbjct: 307 YKSKESGRNRCTL 319


>UniRef50_C6BZS4 Diguanylate cyclase with PAS/PAC and GAF sensors n=1
           Tax=Desulfovibrio salexigens DSM 2638 RepID=C6BZS4_DESAD
          Length = 635

 Score =  231 bits (589), Expect = 3e-59,   Method: Composition-based stats.
 Identities = 54/185 (29%), Positives = 95/185 (51%), Gaps = 8/185 (4%)

Query: 127 MVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDID 183
           + +  +     ++++V   A  D+LT  ++R       ++   + T++   L +M+LDID
Sbjct: 451 ITAHDITEQKEMLEEVKRLASTDYLTGAHNRRHFMSRAETELDRLTRYGGELYLMMLDID 510

Query: 184 YFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAE 243
           +FK+IND YGH  GD VL    +   + +    +  R+GGEEFA  +   +    + +AE
Sbjct: 511 HFKNINDTYGHSVGDVVLKEMVKCCIETLRTSDVFGRLGGEEFAALLVHGSIDSAIQVAE 570

Query: 244 KIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           ++R+ +E       +  + LTVSIG+    A      +D    +  AD CLY++K+ GRN
Sbjct: 571 RLREAIEDMEVRIGRHVVKLTVSIGLTMVCAD-----EDIEIALKHADKCLYQAKEQGRN 625

Query: 304 RTSTM 308
           R  + 
Sbjct: 626 RVVSY 630


>UniRef50_C8WZ84 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8WZ84_DESRD
          Length = 550

 Score =  231 bits (589), Expect = 3e-59,   Method: Composition-based stats.
 Identities = 51/179 (28%), Positives = 85/179 (47%), Gaps = 7/179 (3%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKS 187
            +       + +   +  D LT +++R      +      + +  + LT+ +LDID+FK 
Sbjct: 363 DITHQQQYQEHLKRLSRTDELTGLFNRRHFITLMHKEFSRARRTHERLTLAMLDIDHFKD 422

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           +ND YGH+ GD VL    R +++ V    + AR GGEEFA+  P  +      + E++R 
Sbjct: 423 VNDKYGHDVGDHVLQHLGRILREDVRPYDIAARYGGEEFAICFPDTDLSQADHICERLRT 482

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
                  +    T+  TVS G+   R  +    +D + L+  AD  LY +K +GRNR  
Sbjct: 483 LCAASEVSRNGGTIGFTVSFGLSELRPEH----EDLDGLLKSADNALYAAKANGRNRIE 537


>UniRef50_UPI0000384142 COG2199: FOG: GGDEF domain n=1 Tax=Magnetospirillum magnetotacticum
           MS-1 RepID=UPI0000384142
          Length = 445

 Score =  230 bits (588), Expect = 4e-59,   Method: Composition-based stats.
 Identities = 50/185 (27%), Positives = 83/185 (44%), Gaps = 7/185 (3%)

Query: 126 IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDI 182
           + +   V     L +++   A  D LT + +R    E   +  ++  +    L V++LD+
Sbjct: 263 VALKEDVTETKRLQEELTRLASQDSLTGIANRRHFLERAHTEIIRAGRAKTPLAVLMLDV 322

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           D+FK IND YGH  GD  L   A   +  + +  L  R+GGEEF +  P  +       A
Sbjct: 323 DHFKKINDEYGHAAGDAALKALADTCRSTLRETDLFGRLGGEEFGILFPGDDLNAATEAA 382

Query: 243 EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           E++R  +     T    T+ +T S+G+   +          +  +  AD  LY +K+ GR
Sbjct: 383 ERLRLAIAATKITIGGATIAITASLGLSLLQDG----EKSIDAALSRADQALYVAKQAGR 438

Query: 303 NRTST 307
           NR   
Sbjct: 439 NRLEI 443


>UniRef50_C9QDN5 Putative uncharacterized protein n=1 Tax=Vibrio orientalis CIP
           102891 RepID=C9QDN5_VIBOR
          Length = 457

 Score =  230 bits (588), Expect = 4e-59,   Method: Composition-based stats.
 Identities = 64/197 (32%), Positives = 106/197 (53%), Gaps = 6/197 (3%)

Query: 117 GIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLT 176
           GI+   +  I+V+   AA N+  +++ L A  D LT++ +R   +E  +     + + L 
Sbjct: 264 GISAFIVQRIIVN-DCAARNAYEQKLYLEATTDPLTKLSNRRHFFEIGEQLVQNEMEPLA 322

Query: 177 VMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPV 236
           V+++DID+FK INDNYGH+ GD  LS FA    + +    ++ R+GGEEFA+ + +V+  
Sbjct: 323 VVIIDIDHFKKINDNYGHQVGDLALSRFAEMCCREIRASDIIGRIGGEEFAIILLNVDLA 382

Query: 237 DGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYR 296
               + E+IRK V    F  +  +L +T+S+GV     ++         L+  AD  LY+
Sbjct: 383 IVNEVTERIRKRVAESNFNSEVSSLSMTISLGVALSDQAH-----TLEHLIKRADGALYQ 437

Query: 297 SKKDGRNRTSTMRYGEE 313
           +K  GRNR       +E
Sbjct: 438 AKVSGRNRVVISEQVKE 454


>UniRef50_Q3ADQ4 Response regulator/sensory box protein/GGDEF domain protein n=1
           Tax=Carboxydothermus hydrogenoformans Z-2901
           RepID=Q3ADQ4_CARHZ
          Length = 668

 Score =  230 bits (588), Expect = 4e-59,   Method: Composition-based stats.
 Identities = 56/228 (24%), Positives = 100/228 (43%), Gaps = 13/228 (5%)

Query: 81  LTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMK 140
           L  +T   + +  A  ++    GS   + ++       +   +    +   +     L +
Sbjct: 442 LCLITAVGQEMDWAERILHRMDGSQLPVLKIVKRLRTKSGEKLIETFI--DLTERKKLEE 499

Query: 141 QVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGHECG 197
           Q+   +  D+LTQ Y+R    E L+    +  +      +++LDID+FK++ND +GH  G
Sbjct: 500 QLYRLSITDYLTQAYNRRYFTEMLEREIERAKRTKMPFALIMLDIDHFKNVNDRFGHAAG 559

Query: 198 DKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ 257
           D VL   A  I+  +     +AR GGEEF + +P+        +AE++R+ + +      
Sbjct: 560 DLVLKTLANLIKNRIRQTDCLARWGGEEFVILLPNTPVEKAAGLAEELREQLSMLEIPGV 619

Query: 258 QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
                +T S GV           D  + L++ AD  LY +K  GRN  
Sbjct: 620 G---RVTASFGVTGYCP-----GDTLDTLLMRADQMLYTAKASGRNCV 659


>UniRef50_A1VA66 Diguanylate cyclase with PAS/PAC sensor n=3 Tax=Desulfovibrio
           vulgaris RepID=A1VA66_DESVV
          Length = 827

 Score =  230 bits (588), Expect = 4e-59,   Method: Composition-based stats.
 Identities = 63/203 (31%), Positives = 102/203 (50%), Gaps = 7/203 (3%)

Query: 107 SIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EA 163
            +     AR          +  +  +    +L   +   A  D LT V +R   +     
Sbjct: 609 PVNVEVHARRIEFEGRFVVLSSARDITERKNLEAALLREATTDPLTGVRNRRQFFVDANR 668

Query: 164 LKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGG 223
             + +L+    L V++LDID+FK++ND YGH+ GD+VL  FA    + +    +  R+GG
Sbjct: 669 EFARALRHDSGLAVLMLDIDHFKNVNDLYGHQAGDEVLRAFAACCVEALRAYDVFGRLGG 728

Query: 224 EEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDF 283
           EEFA  +P+ +P + +  AE++RK VE +   ++   L  TVS+GV S  A+ L     F
Sbjct: 729 EEFAALLPAASPEEAMETAERLRKRVERRSVVYEGTALQCTVSVGVTSLAAADLG----F 784

Query: 284 NKLMVEADTCLYRSKKDGRNRTS 306
           + ++  AD  LY +K  GRNR+ 
Sbjct: 785 DDMLRRADRALYAAKDHGRNRSE 807


>UniRef50_C1XLF8 Diguanylate cyclase (GGDEF) domain-containing protein n=1
           Tax=Meiothermus ruber DSM 1279 RepID=C1XLF8_MEIRU
          Length = 373

 Score =  230 bits (588), Expect = 5e-59,   Method: Composition-based stats.
 Identities = 70/315 (22%), Positives = 131/315 (41%), Gaps = 23/315 (7%)

Query: 15  LIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASV-VIGGAGSLAFPL-------PAL 66
           L++P  +             + +     + +++IA   ++      A+ L       PA 
Sbjct: 58  LLLPMAVGFIALEFHLWRNPQNVRWVWQIALALIAIYEIVSLFYEAAYKLHQRDGITPAA 117

Query: 67  IWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVG---SPFSIPQMFSARLGIATMAI 123
           +W  + Y      L         +V +   ++  +VG   SP       +  L      I
Sbjct: 118 LWFPMVYLMAFNLLNRRQALRFSLVYLVLGLLAGAVGMLMSPSINVSSINTALQFTFSNI 177

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLL 180
             + + +  A +     Q+   A  D LT + +R  + + L+     + +  +   ++L 
Sbjct: 178 AYLALLYMFAYLRRHYAQMHQMAHTDALTNLTNRRAMQQKLEGELDRARRYNRPFALLLA 237

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           D+D+FK IND YGH  GD+VL   A  + + + +   +AR GGEEF +  P  +     L
Sbjct: 238 DLDHFKQINDTYGHSVGDQVLREVAGRLAQHLRESDSLARWGGEEFLILAPETDLQQAYL 297

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           +A+++   +   P +     + +T+S+GV   R       D    L+  AD  +YR+K  
Sbjct: 298 LAQRLLGAIRESPISG----VQVTLSLGVACYRQ-----GDSIAALLSRADEAMYRAKAG 348

Query: 301 GRNRTSTMRYGEEVV 315
           GRN+       E++V
Sbjct: 349 GRNQIVLEEELEDIV 363


>UniRef50_Q6ALC0 Putative uncharacterized protein n=1 Tax=Desulfotalea psychrophila
           RepID=Q6ALC0_DESPS
          Length = 652

 Score =  230 bits (587), Expect = 5e-59,   Method: Composition-based stats.
 Identities = 62/180 (34%), Positives = 96/180 (53%), Gaps = 8/180 (4%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH----LTVMLLDIDYFK 186
            +       +++   A  D LT + +RS L+E  ++   +Q       L++++LDIDYFK
Sbjct: 475 DITTKRQSREKLQRLATTDSLTGLCNRSQLFEIAEAELERQRHSSEHNLSLVMLDIDYFK 534

Query: 187 SINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIR 246
            IND +GH  GD VL  FA   +K + D  + AR+GGEEF + +P  +    L +AE+ R
Sbjct: 535 KINDAHGHAAGDLVLKAFADIGRKYLRDVDVFARIGGEEFIILLPGTDIKVALKIAERFR 594

Query: 247 KGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
             VE  P    +K +  TVS GV +       +   F +++ EAD+ LY +K+ GRNR  
Sbjct: 595 ALVEKNPVMVNEKEIAFTVSFGVTAWNG----IEQTFEEVLHEADSALYVAKEKGRNRVE 650


>UniRef50_A6Q2P1 Putative uncharacterized protein n=1 Tax=Nitratiruptor sp. SB155-2
           RepID=A6Q2P1_NITSB
          Length = 486

 Score =  230 bits (587), Expect = 5e-59,   Method: Composition-based stats.
 Identities = 63/195 (32%), Positives = 98/195 (50%), Gaps = 16/195 (8%)

Query: 117 GIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQ 173
            I  + +  I+  F+++ I     +    A  D LT +++R    E  +     S +  +
Sbjct: 304 SILILFLFTILFYFAISRI-----KFEEMATVDKLTGLFNRHKFQEIAEIEIKRSHRHKR 358

Query: 174 HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSV 233
            L+V+L DID+FK IND YGH+ GD VL   A+ I++ +       R GGEEF +  P  
Sbjct: 359 PLSVILFDIDHFKKINDTYGHDIGDVVLRELAKIIKQNIRKYDYAIRWGGEEFLILTPET 418

Query: 234 NPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTC 293
           +      MAEK+RK VE   F    K   +T+S+GV S   +     +  ++ + +AD  
Sbjct: 419 DEKQAFAMAEKLRKAVESHTFPEVGK---VTISLGVASVDPN-----ESIDQAIKKADNA 470

Query: 294 LYRSKKDGRNRTSTM 308
           LY SK  GRN+T+  
Sbjct: 471 LYGSKLGGRNKTTVA 485


>UniRef50_Q21HV6 Response regulator receiver modulated diguanylate cyclase n=2
           Tax=Alteromonadales RepID=Q21HV6_SACD2
          Length = 301

 Score =  230 bits (587), Expect = 5e-59,   Method: Composition-based stats.
 Identities = 57/230 (24%), Positives = 104/230 (45%), Gaps = 13/230 (5%)

Query: 78  TCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINS 137
             +++  TG   I+   +      V  P   P +       A      + +  +   +  
Sbjct: 78  VIMVSATTGDQSIIRALDLGAHDFVSKPIEYPVL-------AARMRSALRLIQAKRDLEK 130

Query: 138 LMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGH 194
             K++   A  D LT + +R   ++  ++    +++  + + +++LD D+FK IND YGH
Sbjct: 131 ANKELERLATRDPLTGINNRRSFFKLAEAELTKTIRHGRDIALLMLDADHFKMINDTYGH 190

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
             GD+ L       Q    +  ++AR+GGEEFA+  P  N      +AE+IR+  E    
Sbjct: 191 AAGDEALLTITEICQNACRESDILARLGGEEFAICCPDTNLEGAYAVAERIRQQCENTVI 250

Query: 255 TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
                +  +T+SIG+ +   S         +++  AD  LY++K+ GRNR
Sbjct: 251 EHNSASFGITLSIGITTFVPSQ---DKSITEMLQRADNLLYQAKEMGRNR 297


>UniRef50_A0L4D8 Diguanylate cyclase n=2 Tax=cellular organisms RepID=A0L4D8_MAGSM
          Length = 464

 Score =  230 bits (587), Expect = 5e-59,   Method: Composition-based stats.
 Identities = 54/177 (30%), Positives = 91/177 (51%), Gaps = 4/177 (2%)

Query: 132 VAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPS---LKQTQHLTVMLLDIDYFKSI 188
           +  +   +K+    +  D LTQV +R  L+++L   +    +  + L+++++D+D+FK I
Sbjct: 274 LQQVQDDLKKAKEESLTDPLTQVANRRALFQSLTRETARTRRYGEPLSLIIIDLDHFKKI 333

Query: 189 NDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKG 248
           ND YGH  GD+VL   A H + ++ D   +AR GGEEF   +P       +  AE+IR  
Sbjct: 334 NDTYGHPVGDRVLKEVAGHARALLRDSDTLARYGGEEFVALLPETTLPQAMEKAEQIRLS 393

Query: 249 VELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
           V    F  + ++L ++ S+GV           ++    +  AD  LYR+K  GRN  
Sbjct: 394 VAAMRFKLKGESLSISASLGVAQLDDGASQDANN-EAFVHRADQALYRAKSGGRNCV 449


>UniRef50_A8UT68 Putative uncharacterized protein n=2 Tax=Aquificaceae
           RepID=A8UT68_9AQUI
          Length = 620

 Score =  230 bits (587), Expect = 5e-59,   Method: Composition-based stats.
 Identities = 67/189 (35%), Positives = 95/189 (50%), Gaps = 10/189 (5%)

Query: 132 VAAINSLMKQVALRADFDFLTQVYSRSGLYE---ALKSPSLKQTQHLTVMLLDIDYFKSI 188
           V    SLM+ +  ++  D LT +Y+R  L E    L +   ++   L ++++DIDYFK I
Sbjct: 434 VLESKSLMELLQQQSYIDQLTGLYNRRFLDEIADKLSAQVKRRGTSLGILMIDIDYFKQI 493

Query: 189 NDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKG 248
           ND YGH+ GD+VL   A  I+  V +   V R GGEE  V +  V       +AEKIR+ 
Sbjct: 494 NDKYGHDVGDRVLKEIASIIKSSVREADYVIRFGGEEILVLLVDVREGTAKKVAEKIRRA 553

Query: 249 VELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS-- 306
           +E +        +  TVSIGV             F + +  AD  LYR+K++GRNR    
Sbjct: 554 IENKVIEISGGVIKKTVSIGVSEFPK---DCDGKFWQCIKFADVALYRAKEEGRNRVVRF 610

Query: 307 --TMRYGEE 313
              M  GEE
Sbjct: 611 TPEMWSGEE 619


>UniRef50_A6VWF8 Diguanylate cyclase n=1 Tax=Marinomonas sp. MWYL1
           RepID=A6VWF8_MARMS
          Length = 368

 Score =  230 bits (587), Expect = 5e-59,   Method: Composition-based stats.
 Identities = 86/314 (27%), Positives = 140/314 (44%), Gaps = 33/314 (10%)

Query: 10  FSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWC 69
           F   +L++     L            + +  +AL +     V  GG  S        +W 
Sbjct: 63  FLVSILLLITFYILKTSSYRHYHNCSRFIAIVALYILCFYLVCAGGVNS-----SGPLWI 117

Query: 70  AVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQM--------FSARLGIATM 121
            V   P +T    F+     I+  A  +  +S+   F   QM        F  RL    +
Sbjct: 118 YV--IPSIT--FAFLGLKQGIIANAAFIFIVSIMLFFPNDQMLLTTYSYEFKTRLIYVFL 173

Query: 122 AICPIMVSFSVAAINSLMK------QVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHL 175
            I  +   + VA   S M+      +   +A FD+LT + +R G+ + L     +Q +H 
Sbjct: 174 TIVTLSGLYEVARYRSFMRLKTMKDKYEYQAQFDYLTFLPNRRGIQKILNKD-QRQRKHT 232

Query: 176 ----TVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVP 231
               T+ +LDID FK IND +GHE GD VL   +R ++  +  +  +AR GGEEF + +P
Sbjct: 233 HKVSTIAILDIDKFKVINDEFGHEVGDMVLKHTSRVLRDCIRSQDSLARWGGEEFLLLLP 292

Query: 232 SVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEAD 291
                + L++ E IR+ VE  PF     ++++T+S+G+            DFN+ +  +D
Sbjct: 293 ETTEQEALVLLESIRECVEETPFGHGNISIFITLSVGLCETSPDV-----DFNETIKFSD 347

Query: 292 TCLYRSKKDGRNRT 305
             LYR+K+ GRN  
Sbjct: 348 VSLYRAKQAGRNTV 361


>UniRef50_C5SA57 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Allochromatium
           vinosum DSM 180 RepID=C5SA57_CHRVI
          Length = 434

 Score =  230 bits (587), Expect = 5e-59,   Method: Composition-based stats.
 Identities = 52/199 (26%), Positives = 91/199 (45%), Gaps = 6/199 (3%)

Query: 119 ATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQHL 175
           A   +  + +   +     L + +      D LTQ+++R   +   E      L+    +
Sbjct: 234 AGQVVGAMEIIRDITDSKRLEEDLRQLTRLDPLTQLFNRRYFFTLAEQEYQRFLRYHHPM 293

Query: 176 TVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNP 235
            + ++DID+FKS+ND YGH  GD VL + A+ +   +    ++AR GGEEF + +P  + 
Sbjct: 294 ALCMIDIDHFKSVNDRYGHLVGDTVLCIVAQTLHDNLRQVDILARYGGEEFVILLPETDL 353

Query: 236 VDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLY 295
                  E++R  V  +        + +T+S+GV +             +L+  AD  LY
Sbjct: 354 QTACASTERLRVAVAERRIETPSGPVSVTLSLGVVAIADG---PAMTLERLLDAADQMLY 410

Query: 296 RSKKDGRNRTSTMRYGEEV 314
           R+K+ GRNR      G  +
Sbjct: 411 RAKQAGRNRVEIWDLGRSM 429


>UniRef50_UPI0001AEC0DE GGDEF domain protein n=1 Tax=Alteromonas macleodii ATCC 27126
           RepID=UPI0001AEC0DE
          Length = 329

 Score =  230 bits (587), Expect = 6e-59,   Method: Composition-based stats.
 Identities = 52/177 (29%), Positives = 92/177 (51%), Gaps = 7/177 (3%)

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDN 191
           +  L +++   +  D LT +Y+R    E         +++ +  T ++LDID+FK IND 
Sbjct: 151 MEHLNEELKTASRVDGLTGLYNRRYWQERFDEMHKLCVRREKPSTALMLDIDHFKRINDT 210

Query: 192 YGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVEL 251
           YGH+ GDKV+ + A  I++ V +  L  R GGEEFA+ +   +  D  ++AE+IR+  + 
Sbjct: 211 YGHQAGDKVIKMLAALIKRCVRETDLAGRYGGEEFAIILNDSSVEDAKIVAERIRQLAQR 270

Query: 252 QPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
                + +++  TVS+G+      +          +  AD  LY +K++GRN+    
Sbjct: 271 LVVEHEGESISFTVSLGLAQFSPDFKGAM----AWLECADQALYEAKENGRNQYRIY 323


>UniRef50_A3J836 Putative diguanylate cyclase (GGDEF domain) n=1 Tax=Marinobacter
           sp. ELB17 RepID=A3J836_9ALTE
          Length = 588

 Score =  230 bits (587), Expect = 6e-59,   Method: Composition-based stats.
 Identities = 84/314 (26%), Positives = 142/314 (45%), Gaps = 22/314 (7%)

Query: 11  STGVLIVPCMLTLAIPGVLPRFKAEQM-MPAIALIVSVIASVVIGGAGSLAFPLPALIWC 69
           S+G+      L+            + + +   AL V   A    G A  LAF +  L   
Sbjct: 269 SSGLAFATNFLSTKRRQPRLHRTFQTIGVAYFALFVVCFALGEQGLALRLAFLVAPLFSV 328

Query: 70  AVRY----------TPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIA 119
            + Y                +L  +   V   + A++V  +    P++    ++  +G+ 
Sbjct: 329 LMLYMGASSWVAGNQFARYFMLGTLASVVGASITASTVTGMI---PYTQLGYYAVDIGMI 385

Query: 120 TMAICPIMVSFSVAAINSLMKQVALR-ADFDFLTQVYSRSGLY---EALKSPSLKQTQHL 175
             AI  ++    +   N   +  A + A  D LT + +R G     E+L S   ++ +++
Sbjct: 386 VDAILLMLALADLVRKNEEARTAAEQNAQTDLLTGLSNRRGFLPVAESLWSLVTRKNRNV 445

Query: 176 TVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNP 235
            V ++DID FK+IND YGH  GDKVL V A  + +      L+AR GGEEF + +P  + 
Sbjct: 446 CVAMIDIDRFKNINDQYGHAVGDKVLKVIADELYRSRRRGDLLARWGGEEFTLLLPETSE 505

Query: 236 VDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLY 295
            + L +AE+ R  +E      + + +  T+SIGV S  + ++T     ++ +  AD  LY
Sbjct: 506 AEALKVAERFRHNIEQLVTNDRGRVIQCTISIGVTSRHSEHVT----LDQAIARADEELY 561

Query: 296 RSKKDGRNRTSTMR 309
           R+K  GRN+ S  R
Sbjct: 562 RAKLQGRNQVSFGR 575


>UniRef50_Q30SY9 Diguanylate cyclase (GGDEF domain) n=1 Tax=Sulfurimonas
           denitrificans DSM 1251 RepID=Q30SY9_SULDN
          Length = 611

 Score =  230 bits (587), Expect = 6e-59,   Method: Composition-based stats.
 Identities = 57/170 (33%), Positives = 91/170 (53%), Gaps = 11/170 (6%)

Query: 141 QVALRADFDFLTQVYSRSGLYEALKSPSL---KQTQHLTVMLLDIDYFKSINDNYGHECG 197
           ++   A  D LT  Y+R  + E +K       + +++L++++ DID+FK +ND YGH+ G
Sbjct: 449 ELERLASIDKLTGAYNRRMIDEFMKKEIFLHVRDSKNLSLIMADIDHFKLVNDTYGHQAG 508

Query: 198 DKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ 257
           D VLS   R I   +    +  R GGEEF V  P+ +    L++A+KIR+ +E   F   
Sbjct: 509 DAVLSDVGRIISSTIRKSDIFGRYGGEEFIVICPNTSSQQALILAQKIREEIENFHFAEV 568

Query: 258 QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
                 T+S+GV +  A+     D+   ++  AD  LY +KK+GRNR   
Sbjct: 569 GHK---TISLGVATLIAN-----DEVENIIKRADDALYIAKKEGRNRVVL 610


>UniRef50_C5T1B3 Diguanylate cyclase n=1 Tax=Acidovorax delafieldii 2AN
           RepID=C5T1B3_ACIDE
          Length = 445

 Score =  230 bits (587), Expect = 6e-59,   Method: Composition-based stats.
 Identities = 68/249 (27%), Positives = 118/249 (47%), Gaps = 19/249 (7%)

Query: 71  VRYTPQVTCLLT---FVTGAVEIVLVANSVIDISVG---SPFSIPQMFSARLGIATMAIC 124
           VRY   V   L     +   +   LVA   ++ +     +  S   +  A L +  MA  
Sbjct: 197 VRYLFAVVSGLHGVFLLVRPLLFRLVAPGTVEDADAGMVALLSQFVVLEATLSLVLMAFG 256

Query: 125 PIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVMLLD 181
            +M++        + +++   A+ D LT V++R       E   S + +    L V+++D
Sbjct: 257 ALMLT-----NEHITRELRHLAEVDPLTNVFNRRAFLTLLEKAISNAQRTQSGLPVLVID 311

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           +D+FK IND +GH+ GD+VL  F       +  + ++ R+GGEEFA+ +P+ +      +
Sbjct: 312 LDHFKKINDTWGHQSGDEVLRHFVALANGCLRKEDVMGRLGGEEFAIFLPNASSEGSQAV 371

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
           AE++R  V   P    +  + LTVSIGV           +  + ++  AD  +YR+K+ G
Sbjct: 372 AERLRALVAHHPAMTGRGPIALTVSIGVTQYGG-----GETSDFVLQRADEAMYRAKERG 426

Query: 302 RNRTSTMRY 310
           RNR  T+  
Sbjct: 427 RNRVETLSP 435


>UniRef50_Q74AN9 Response regulator n=1 Tax=Geobacter sulfurreducens
           RepID=Q74AN9_GEOSL
          Length = 301

 Score =  230 bits (587), Expect = 6e-59,   Method: Composition-based stats.
 Identities = 67/234 (28%), Positives = 116/234 (49%), Gaps = 16/234 (6%)

Query: 75  PQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAA 134
                LLT   G  +++   ++  D  VG PFS+ ++  AR+ +    +         + 
Sbjct: 75  LPYILLLTAKNGTDDVIRGLDAGADDYVGKPFSLGEL-RARIQVGRRTV------ELHSR 127

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDN 191
           +    + +  +A  D LT V +R  + + L+    +  +    L++ +LDID+FK +ND 
Sbjct: 128 LQETQEALNHQATHDPLTGVMNRRAIIDHLEKELSRVKRDGGSLSIGILDIDHFKRVNDR 187

Query: 192 YGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVEL 251
           YGH+ GD+VL      +  ++ D  L+ R+GGEEF V  P     D   + E++R  +  
Sbjct: 188 YGHQTGDEVLCGCVGVLGGLLRDYDLLGRLGGEEFLVVAPGTG-DDCNHLYERLRAAIAS 246

Query: 252 QPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
             FT + K + +TVSIGV +   +        ++L+  AD  LYR+K+ GR+R 
Sbjct: 247 TKFTSRAKPVSVTVSIGVAACDGTA-----GLDELLAAADDALYRAKRSGRDRV 295


>UniRef50_Q2RLY1 Diguanylate cyclase (GGDEF domain) n=1 Tax=Moorella thermoacetica
           ATCC 39073 RepID=Q2RLY1_MOOTA
          Length = 357

 Score =  229 bits (586), Expect = 6e-59,   Method: Composition-based stats.
 Identities = 57/176 (32%), Positives = 95/176 (53%), Gaps = 6/176 (3%)

Query: 137 SLMKQVALRADFDFLTQVYSRSGLYEALKS--PSLKQTQHLTVMLLDIDYFKSINDNYGH 194
             +  + + A  D LT +Y+     +A  +   S +Q ++L V++LDIDYFK IND YGH
Sbjct: 177 KRLAAMEMAAITDDLTGIYNYRYFVQAFSNLLNSRQQPRYLAVLMLDIDYFKEINDAYGH 236

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
             G++VL+  A  +++   ++ +V R GGEEFA+ +P  +    L +AE+IRK +    F
Sbjct: 237 LTGNRVLAELATILKECTREQDVVTRFGGEEFALILPDTDYHGALQVAERIRKAIAEHTF 296

Query: 255 TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRY 310
             +   +++TVS GV      +     D   ++  AD  LY++K  GRN     ++
Sbjct: 297 QAEGTAIHVTVSAGVAV----WPVDGTDKKDIIARADRALYQAKTTGRNSVCAYQF 348


>UniRef50_A0L7F5 Cyclic nucleotide-binding protein n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0L7F5_MAGSM
          Length = 320

 Score =  229 bits (586), Expect = 6e-59,   Method: Composition-based stats.
 Identities = 54/181 (29%), Positives = 92/181 (50%), Gaps = 9/181 (4%)

Query: 132 VAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLK---QTQHLTVMLLDIDYFKSI 188
           +   +   +++   A  D LT +Y+R    E+++    +       L++++LD+D+FK  
Sbjct: 142 IIEGSERQRKLETFAKVDPLTGIYNRRWFDESMQRQMRRVEHSQNPLSLIMLDVDHFKRY 201

Query: 189 NDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKG 248
           ND +GH+ GD+ L   A  I   +    + AR GGEEFAV +P  + V G ++AE++R  
Sbjct: 202 NDTHGHQGGDEALIALAHTISLHLRPGDIAARYGGEEFAVVLPDTDAVSGRMIAERLRTA 261

Query: 249 VELQPFTWQQKT--LYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
           VE       +      +T+S+GV     +     D  ++L+  AD  LY++K  GRNR  
Sbjct: 262 VEALEIKDDEGNSLSGITISLGVAQTSGTV----DSVSELIATADAALYQAKNQGRNRVV 317

Query: 307 T 307
            
Sbjct: 318 V 318


>UniRef50_A1SVZ1 Diguanylate cyclase n=1 Tax=Psychromonas ingrahamii 37
           RepID=A1SVZ1_PSYIN
          Length = 477

 Score =  229 bits (586), Expect = 7e-59,   Method: Composition-based stats.
 Identities = 60/206 (29%), Positives = 103/206 (50%), Gaps = 9/206 (4%)

Query: 104 SPFSIPQMFSARLGIATMAICPIMVSFSV-AAINSLMKQVALRADFDFLTQVYSRSGLYE 162
           S F +    +    +    +  I+++F +   +N   K++   A +D LT + +R    E
Sbjct: 274 SEFLLNVQKTFYFNLLCSLLGTILIAFLILKTVNKYYKEMEHLAKYDALTNLKNRRAFNE 333

Query: 163 ALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVA 219
            L+       ++  HL++   D+D FKS+ND +GH+ GDKVL   A  ++  +    ++ 
Sbjct: 334 ELEHSLLLCKRRASHLSLTFFDLDDFKSVNDTFGHQTGDKVLQYVADILKDDIRQTDIIG 393

Query: 220 RMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTL 279
           R GGEEF VA       D   + EKIR  +E   F  Q K + +T S G+ +     +T 
Sbjct: 394 RWGGEEFIVAFIDTELEDAKFITEKIRAHIEKDSFLSQLKNMKVTASFGLTT-----ITT 448

Query: 280 TDDFNKLMVEADTCLYRSKKDGRNRT 305
            D  + L+  AD  LY++K++G+N+ 
Sbjct: 449 QDTLDSLLERADQALYKAKENGKNQV 474


>UniRef50_Q2BQN9 Diguanylate cyclase, putative n=1 Tax=Neptuniibacter caesariensis
           RepID=Q2BQN9_9GAMM
          Length = 529

 Score =  229 bits (586), Expect = 7e-59,   Method: Composition-based stats.
 Identities = 57/180 (31%), Positives = 95/180 (52%), Gaps = 8/180 (4%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKS 187
               + + M++  LRA  D LT + +R+   E +     + +++    +V++ D+D+FK 
Sbjct: 354 ETRKVKAHMEEERLRARTDPLTGLPNRAAYDEQIAQEYERWSRYRTSFSVVVADLDFFKK 413

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           IND YGH  GDKVL + A+ I K +     VAR GGEEF + +PS    +     +K+R+
Sbjct: 414 INDTYGHLAGDKVLRLVAKVITKNIRVTDFVARYGGEEFVILLPSTVAEEAAQAMDKLRE 473

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
            +   PF +  K + +T+S GV       +   D  + +   AD  LY++K+DGRN   +
Sbjct: 474 SLASSPFNFHGKPVGITMSFGVTE-----IKEGDSLDDVFTRADEALYQAKEDGRNLVRS 528


>UniRef50_C5BK03 Ggdef domain protein n=1 Tax=Teredinibacter turnerae T7901
           RepID=C5BK03_TERTT
          Length = 580

 Score =  229 bits (586), Expect = 7e-59,   Method: Composition-based stats.
 Identities = 56/178 (31%), Positives = 88/178 (49%), Gaps = 8/178 (4%)

Query: 133 AAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLK---QTQHLTVMLLDIDYFKSIN 189
           +    L+++   RA  D LT + +R    E +     +    ++ L + + DID+FK IN
Sbjct: 401 SKTKELLEEERYRATHDSLTGLPNREAYNERVYQEYRRFTRYSRPLGIAVCDIDHFKKIN 460

Query: 190 DNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGV 249
           DN+GH+ GD+VL + AR I   +     VAR GGEEF + +P  +      + +KIR  V
Sbjct: 461 DNFGHQTGDRVLKLIARLISTRLRKVDFVARYGGEEFVILLPETSASQSRSVLDKIRAAV 520

Query: 250 ELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
               F +    + +T+S G+ + R+      D        AD  LY++K DGRNR   
Sbjct: 521 AKAAFRFGDDPVKITLSFGISAFRSD-----DTIETAFQRADKALYQAKADGRNRCVV 573


>UniRef50_A5V1I0 Diguanylate cyclase with GAF sensor n=2 Tax=Roseiflexus
           RepID=A5V1I0_ROSS1
          Length = 681

 Score =  229 bits (586), Expect = 7e-59,   Method: Composition-based stats.
 Identities = 54/177 (30%), Positives = 88/177 (49%), Gaps = 6/177 (3%)

Query: 137 SLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYG 193
            L  +    A  D LT V++R   +E ++    +  +    L ++++D+D+FKS+ND YG
Sbjct: 500 HLFAEARRHATIDELTGVWNRRTFFENVRREFQRSQRTLHPLAILMIDVDHFKSVNDTYG 559

Query: 194 HECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP 253
           H  GD+VL   A   +  +    ++ R GGEEFAVA+P  +      +AE++R  VE  P
Sbjct: 560 HAAGDQVLRGVAERCRNQLRVIDIIGRYGGEEFAVALPETDIHAAGQIAERLRIAVERAP 619

Query: 254 FTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRY 310
           F     ++ LT+S+G               + ++  AD  LY +K+ GRN      Y
Sbjct: 620 FVTDYGSISLTISVGAAVYHPDDHV---TLDAVIDRADRALYIAKRSGRNSVRVWSY 673


>UniRef50_A1VD57 Diguanylate cyclase n=3 Tax=Desulfovibrio vulgaris
           RepID=A1VD57_DESVV
          Length = 487

 Score =  229 bits (586), Expect = 7e-59,   Method: Composition-based stats.
 Identities = 62/193 (32%), Positives = 102/193 (52%), Gaps = 7/193 (3%)

Query: 122 AICPIMVSFSVAAINSL-MKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTV 177
           A+  +M   ++A  N++  +++ L+AD D LTQ+++R      L     +  +    +T+
Sbjct: 288 ALDSVMRHLTLALRNAVVYREIKLQADHDALTQLHNRRSFDHRLAEEVDRHQRYGMPMTL 347

Query: 178 MLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVD 237
           ++LDID+FK++ND YGH  GD VL   A+ ++         AR GGEEF V +P  +   
Sbjct: 348 LMLDIDHFKAVNDTYGHPAGDAVLREVAQTMRNACRTTDFAARYGGEEFCVILPHTDGKC 407

Query: 238 GLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRS 297
           G + AE++RK +         KT+ +TVSIG+ +  A+         +L+ EAD  LY +
Sbjct: 408 GRIFAERLRKRLASSRVEVDGKTIAVTVSIGLATLSAAAPL---SPERLVCEADGALYAA 464

Query: 298 KKDGRNRTSTMRY 310
           K  GRN     + 
Sbjct: 465 KAAGRNIVCEAQE 477


>UniRef50_C7R6Y0 Diguanylate cyclase n=1 Tax=Kangiella koreensis DSM 16069
           RepID=C7R6Y0_KANKD
          Length = 469

 Score =  229 bits (586), Expect = 7e-59,   Method: Composition-based stats.
 Identities = 66/260 (25%), Positives = 123/260 (47%), Gaps = 15/260 (5%)

Query: 64  PALIWCAVRYTPQVT-------CLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARL 116
            A+IW A+                L  +  A   +L++  V+   + +  S   ++S   
Sbjct: 212 IAMIWFALSCLSFSIGTVWDHQWWLAHIIFASGFLLLSFGVVQAFLTT-GSFKTIYSQTE 270

Query: 117 GIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH-- 174
               +         ++  + ++ +++   A  D LT+V +R    +  +    + +++  
Sbjct: 271 LFQQIIREKKKSERALIELKAVNQKLEELAATDSLTRVANRREFMKRSEEEMSRSSRNST 330

Query: 175 -LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSV 233
            L +M++D D+FK IND YGH+ GDKVL  F +  ++++    L+ R+GGEEFA+ +P  
Sbjct: 331 DLCLMVIDFDHFKEINDQYGHQAGDKVLKDFVKLAKEVMRPSDLLGRIGGEEFALLLPET 390

Query: 234 NPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTC 293
           N    + +AE++R+ +E +      K + LT+SIGV   +       D   K +  AD  
Sbjct: 391 NIRSAVKVAERLRQHIEEESIVIGSKRIKLTISIGVAEYQP----KVDTVKKWLHRADEF 446

Query: 294 LYRSKKDGRNRTSTMRYGEE 313
           LY++K  GRNR     +  +
Sbjct: 447 LYQAKDKGRNRVVVEAFDAD 466


>UniRef50_C8X007 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8X007_DESRD
          Length = 531

 Score =  229 bits (586), Expect = 8e-59,   Method: Composition-based stats.
 Identities = 61/186 (32%), Positives = 96/186 (51%), Gaps = 7/186 (3%)

Query: 126 IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDI 182
           +++   V+       ++   A  D LT +Y+R   +E  +     + + +  +T++LLDI
Sbjct: 337 LVLMRDVSERKEAESRLLQMAATDELTGLYNRRRFFELARGEFNRAKRYSSPMTILLLDI 396

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           DYFK IND YGH+ GD  L      I   +    ++AR+GGEEF   +P  +  D   +A
Sbjct: 397 DYFKRINDEYGHDAGDTALRCIVSMIASQLRSLDVLARLGGEEFVALLPETHQFDAERIA 456

Query: 243 EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           E+IR  +E       + TL++TVSIGV      Y     D  +L+  AD  +YR+K+DGR
Sbjct: 457 ERIRSEIESTAINLFETTLFVTVSIGVA----GYSKEMQDVGELINRADEAMYRAKRDGR 512

Query: 303 NRTSTM 308
           N+    
Sbjct: 513 NQVCLA 518


>UniRef50_A0LAY9 Diguanylate cyclase n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0LAY9_MAGSM
          Length = 220

 Score =  229 bits (586), Expect = 8e-59,   Method: Composition-based stats.
 Identities = 63/195 (32%), Positives = 105/195 (53%), Gaps = 9/195 (4%)

Query: 119 ATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEA---LKSPSLKQTQHL 175
               I  ++ ++ + ++   ++Q+ + A  D LT + +R G  E    +   S + +  L
Sbjct: 25  IMRTIISLVGAWLIYSLRKALQQLEVMATHDKLTGILNRHGFQERGKYIIDQSQRHSWPL 84

Query: 176 TVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNP 235
            V+++DID+FK IND++GH+ GD VL      ++K V    +VAR+GGEEFA+ +P+ + 
Sbjct: 85  AVVMMDIDHFKKINDSFGHDIGDLVLQSLGSELKKSVRSTDIVARLGGEEFALILPNTDS 144

Query: 236 VDGLLMAEKIRKGVELQPFTW-QQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCL 294
                +A+ IRK +E    +    K L  T+S+GV SG        D  + L+ +AD  L
Sbjct: 145 KHAHQIADSIRKKIETSRLSLPDGKFLTYTLSLGVTSGLG-----IDKMDLLLNQADNAL 199

Query: 295 YRSKKDGRNRTSTMR 309
           YR+K  GRNR  +  
Sbjct: 200 YRAKGTGRNRVVSFH 214


>UniRef50_Q3A5K1 Two component signal transduction response regulator n=1
           Tax=Pelobacter carbinolicus DSM 2380 RepID=Q3A5K1_PELCD
          Length = 323

 Score =  229 bits (586), Expect = 8e-59,   Method: Composition-based stats.
 Identities = 73/239 (30%), Positives = 116/239 (48%), Gaps = 16/239 (6%)

Query: 80  LLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLM 139
           +L F +G    + +A   I +S   P  +P M   R+ I       +     + A++   
Sbjct: 82  VLLFSSGDERDLWMAGMEIGVSECLPMGLP-MEEHRIKIR----WHLKNRERIHALHQAQ 136

Query: 140 KQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGHEC 196
            Q+A  A  D LT +Y+R+     +     + ++    L+++++D+D+FK IND YGH  
Sbjct: 137 SQLARIALTDSLTGLYNRAYFDATITQEVARCSRRGLPLSLLMVDLDHFKKINDTYGHLA 196

Query: 197 GDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTW 256
           GD+ L+  A  +++       V R GGEEFAV +P     +   +AE+IRK +      +
Sbjct: 197 GDQALAAVALVLKEQSRISDTVCRFGGEEFAVILPETTNANAATVAERIRKKISQLDLAF 256

Query: 257 QQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV 315
                 +T SIGVGS + +   L D    L+ EAD  LY +K  GRNR  +   G  VV
Sbjct: 257 -----PVTASIGVGSAKVTNQLLPD---HLIAEADGALYEAKSQGRNRVQSSVLGAGVV 307


>UniRef50_B6ER50 Putative GGDEF protein n=1 Tax=Aliivibrio salmonicida LFI1238
           RepID=B6ER50_ALISL
          Length = 413

 Score =  229 bits (586), Expect = 8e-59,   Method: Composition-based stats.
 Identities = 74/282 (26%), Positives = 124/282 (43%), Gaps = 15/282 (5%)

Query: 28  VLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGA 87
           V   FK   + PA   I+   +   +    S  F +P        Y  +    L +   +
Sbjct: 140 VHRHFKPLMVNPAFVRIIGAKSVAEVMAMESFKFIIP-------EYNQEHASNLHYQLIS 192

Query: 88  VEIVLVANSVIDISVGSPFSIPQMFSARLGI-ATMAICPIMVSFSVAAINSLMKQVALRA 146
            +I    + V +I +       Q+F + +     +A+   ++   V     L +++  +A
Sbjct: 193 GDIENTNSVVENIRLDGESRFFQLFESVIDWDGELAVQSSII--DVTEKYHLERKIEFQA 250

Query: 147 DFDFLTQVYSRSGLYEALKSPSLKQTQHL-TVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
             D LT + +R  + E L     +  +   T +L+DID FK IND +GH  GD V+  FA
Sbjct: 251 KHDDLTGLLNRRAITEFLLKEQEEHLRPSQTCLLIDIDNFKLINDQFGHSAGDSVIQQFA 310

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
                 V D G++ R GGEEF +  P +N      +AEKIR   E   F +      +TV
Sbjct: 311 ELCSTFVKDNGVIGRWGGEEFIIFFPQLNVEQANNIAEKIRYACEEVHFIFNDIQHSITV 370

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
           SIG+ +     L+ +     L+  AD  +Y++K+ G+N+   
Sbjct: 371 SIGISTC----LSTSCSIEALVQNADNNMYQAKQQGKNQIVL 408


>UniRef50_Q2BLA2 Putative uncharacterized protein n=1 Tax=Neptuniibacter
           caesariensis RepID=Q2BLA2_9GAMM
          Length = 811

 Score =  229 bits (586), Expect = 8e-59,   Method: Composition-based stats.
 Identities = 59/191 (30%), Positives = 105/191 (54%), Gaps = 6/191 (3%)

Query: 127 MVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDID 183
            VS  +         +   A  D LT + +R      L++    + +  + L++ +LD+D
Sbjct: 623 FVSLLIEE-QQTEANLHRLATTDELTSLANRRKFLTTLEAELARAKRYHRELSLCMLDLD 681

Query: 184 YFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAE 243
           +FK IND+ GH  GD VL   A+ ++ ++ +  +  R+GGEEFA+ +P  +  D L++AE
Sbjct: 682 HFKRINDDNGHSAGDSVLVEVAKIMEAMLRESDMAGRIGGEEFAILLPDTSEDDALILAE 741

Query: 244 KIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           ++R+ +E     +Q  TL LT SIGV S   + +      ++L+  AD C+Y +K++GRN
Sbjct: 742 RLREAIESLEIKYQAHTLKLTTSIGVASL--NQMPEIVQASELLSAADDCMYYAKQNGRN 799

Query: 304 RTSTMRYGEEV 314
             S +R  +++
Sbjct: 800 LVSNVRTTQQL 810


>UniRef50_C0QBK1 GGDEF domain family protein n=1 Tax=Desulfobacterium autotrophicum
           HRM2 RepID=C0QBK1_DESAH
          Length = 430

 Score =  229 bits (585), Expect = 8e-59,   Method: Composition-based stats.
 Identities = 58/180 (32%), Positives = 99/180 (55%), Gaps = 11/180 (6%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKS 187
           ++ ++  + + +  +A  D LT +++R    + L S   +  ++   L+++L DID+FK 
Sbjct: 257 NLQSLEGINELLEKQASTDALTGIFNRMKFNQTLTSEIKRAKRYRVALSLILFDIDHFKQ 316

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           +ND+YGH  GD VL   AR +   + +  + AR GGEEF +  P  +    + +AEK+R 
Sbjct: 317 VNDSYGHLSGDTVLKHLARLVASNLREIDIFARWGGEEFVIQAPETSLESAIKLAEKLRS 376

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
            +E   F   +K   +TVS GV + R+S     D+   L+  AD  LYR+K+ GRN+  +
Sbjct: 377 KIENYVFPAPKK---ITVSFGVATFRSS-----DNDITLVNRADEALYRAKEGGRNQVVS 428


>UniRef50_B6BK11 Ggdef/pas/pac-domain containing protein n=1 Tax=Campylobacterales
           bacterium GD 1 RepID=B6BK11_9PROT
          Length = 464

 Score =  229 bits (585), Expect = 8e-59,   Method: Composition-based stats.
 Identities = 57/202 (28%), Positives = 100/202 (49%), Gaps = 8/202 (3%)

Query: 110 QMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSL 169
           + F + + I       I     + A  +L +Q+  +A  D+LT++++R      L+    
Sbjct: 266 EFFGSPIKITEDTTNIIWNILDITAKKNLQEQLETQATTDYLTELHNRRYFTSRLEEEVA 325

Query: 170 KQTQH----LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEE 225
           +  +      ++++ D+D FK IND  GH  GD VL +FA  ++K +    +  R+GGEE
Sbjct: 326 RIKRDKKVTSSLLMFDLDKFKLINDTLGHLMGDVVLKIFADILKKNLRKSDIAGRIGGEE 385

Query: 226 FAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNK 285
           FA+ +PS N  +  ++A +IR+ V  +       ++  TVSIG+ +  +       + + 
Sbjct: 386 FAMILPSTNIREAKVLANRIREEVSNKKTIIDGNSINFTVSIGLTAIASDDA----NSDS 441

Query: 286 LMVEADTCLYRSKKDGRNRTST 307
               ADT LY +K  GRNR   
Sbjct: 442 AFARADTALYMAKGKGRNRVEV 463


>UniRef50_B5ZG65 Diguanylate cyclase with PAS/PAC sensor n=4 Tax=Proteobacteria
           RepID=B5ZG65_GLUDA
          Length = 464

 Score =  229 bits (585), Expect = 8e-59,   Method: Composition-based stats.
 Identities = 55/182 (30%), Positives = 90/182 (49%), Gaps = 8/182 (4%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKS--PSLKQT--QHLTVMLLDIDYFK 186
            V A   + +++   A  D LT + +R    E ++     L+    +   V+++DID FK
Sbjct: 280 DVTARRRMEQELHALARVDHLTGLPNRRAFTEGMEQAWQMLRGGVSRGGAVLMIDIDRFK 339

Query: 187 SINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIR 246
           +IND YGH  GD VL   A  +   +       RMGGEEFA  +P     +   +AE++R
Sbjct: 340 TINDRYGHAAGDAVLRHVATVLMATLRATDFTGRMGGEEFAACLPDTGLDEAGRIAERLR 399

Query: 247 KGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
           + +   P  ++  ++ LTVSIG+   R +     D     +  AD  LY +K++GR+R +
Sbjct: 400 QAIAGTPVPFESHSIALTVSIGISKMRLADAGGDD----ALSRADMALYSAKENGRDRVA 455

Query: 307 TM 308
             
Sbjct: 456 FA 457


>UniRef50_Q6AJ00 Putative uncharacterized protein n=1 Tax=Desulfotalea psychrophila
           RepID=Q6AJ00_DESPS
          Length = 571

 Score =  229 bits (585), Expect = 9e-59,   Method: Composition-based stats.
 Identities = 56/185 (30%), Positives = 97/185 (52%), Gaps = 10/185 (5%)

Query: 126 IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY----EALKSPSLKQTQHLTVMLLD 181
           + +           +++   A  D LT++ +R   +    E L +  L   Q L+V++LD
Sbjct: 390 LWMMDDATKRKKAEEKLVRIAATDSLTKLNNRRHFFSLGHEEL-ALHLHNAQPLSVLMLD 448

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           ID+FK++ND  GH+ GDKVL +F++     +    ++ R+GGEEFAV + +         
Sbjct: 449 IDHFKNVNDTLGHQAGDKVLKIFSKICAVNLRSVDIIGRIGGEEFAVILTNTPRSQAQRT 508

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
           AE+IR  +E  P   +Q    +TVSIG+ + +       ++ + ++  AD  LY++K +G
Sbjct: 509 AERIRLAIETSPEFTKQSLPKITVSIGIATNQP-----PENLDAIICRADKNLYQAKSNG 563

Query: 302 RNRTS 306
           RNR  
Sbjct: 564 RNRIE 568


>UniRef50_Q88RK0 GGDEF domain protein n=3 Tax=Pseudomonas putida RepID=Q88RK0_PSEPK
          Length = 645

 Score =  229 bits (585), Expect = 9e-59,   Method: Composition-based stats.
 Identities = 60/175 (34%), Positives = 99/175 (56%), Gaps = 8/175 (4%)

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDN 191
               +++   +A  D LT + +R+   E ++   L   +   HL + +LD+D+FK INDN
Sbjct: 474 YREHLEEQRQKALLDPLTGLPNRAAWSERVEREMLDWQENGGHLAMAILDLDHFKRINDN 533

Query: 192 YGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVEL 251
           YGH  GDKVL + A  ++K +  +  +AR GGEEF + +P   P     +AE +R  VE 
Sbjct: 534 YGHLAGDKVLKIVADQLRKRLRGRDFIARFGGEEFVMLLPQTTPAVAAQVAEVLRATVEA 593

Query: 252 QPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
            PF ++ + + +T SIG+G+ R+   +     ++++  AD  LYR+K+ GRNR  
Sbjct: 594 CPFHFKGERVVITTSIGLGAFRSGERS-----DQVLKRADAALYRAKELGRNRVE 643


>UniRef50_Q087A8 Diguanylate cyclase n=1 Tax=Shewanella frigidimarina NCIMB 400
           RepID=Q087A8_SHEFN
          Length = 321

 Score =  229 bits (585), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 66/242 (27%), Positives = 113/242 (46%), Gaps = 13/242 (5%)

Query: 73  YTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT---MAICPIMVS 129
           Y P     +  V     +   +    DI V +P S+      +  +       I  I +S
Sbjct: 87  YFPANVVDILHVNDTKVLNSQSKLSDDIIVDTPASLIVYHEVKQPLYNHKGTLIGLIGIS 146

Query: 130 FSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFK 186
             + A   L  ++   A+ D LT +++R       +    + T+     ++M++DID FK
Sbjct: 147 TDITAAYHLRSKLERLANTDPLTGLFNRRSFTSFCEHEFFRATRYFQPFSLMIIDIDLFK 206

Query: 187 SINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIR 246
            +ND YGH  GD+V+   A    + V +  ++AR+GGEEFA+ +P  +     ++AE++R
Sbjct: 207 KVNDTYGHLVGDEVIKRVANICNEHVREADVLARIGGEEFAILLPDTDIDSAYVLAERLR 266

Query: 247 KGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
           +  +      +QKT  +T+SIGV + R+        F ++   AD  LY SK  GRN  +
Sbjct: 267 EAQQQYE---EQKTPSITISIGVATLRSQ----DKAFLEIFKRADKALYSSKNVGRNSVN 319

Query: 307 TM 308
             
Sbjct: 320 VA 321


>UniRef50_C9YC42 Putative uncharacterized protein n=1 Tax=Curvibacter putative
           symbiont of Hydra magnipapillata RepID=C9YC42_9BURK
          Length = 409

 Score =  229 bits (585), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 75/316 (23%), Positives = 139/316 (43%), Gaps = 25/316 (7%)

Query: 12  TGVLIVPCMLTLAIPGVLPRFKAEQ--MMPAIALIVSVIASVVIGGAGSLAFPLPALIWC 69
           TG+     +   A   +  R ++     +P +A+ V ++ +++I        P     + 
Sbjct: 96  TGMGAAFALCAWACRPLEHRHRSWSGRWLPVLAMAVCIVFAMLITAIDQWVTPAITPFFI 155

Query: 70  AVRYTPQVTCLLTFVTGAV--EIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIM 127
           A   T     L   V  A+     ++ +++I ++  +P  +       L +  +  C  +
Sbjct: 156 ACIVTSLTIYLRPHVAAALFGVAFVLFSTLIGMTQHNPEMLLSNRINGLAVCVIGFCLSV 215

Query: 128 VSF---------------SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQT 172
           + +               +   +    +++      D LT +++R+   E   +   +  
Sbjct: 216 LMWRKFTTIAVQKHQLEKAHTELQLKQRELERLTRQDGLTGLFNRNTFVELSTNELKRAK 275

Query: 173 QHLT---VMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVA 229
           +  +   ++LLD+D+FK IND +GH  GD VL   A+ +   V    LV R+GGEEF V 
Sbjct: 276 RQGSATTILLLDLDHFKRINDTWGHPAGDVVLRHVAQTMVNSVRSTDLVGRLGGEEFIVL 335

Query: 230 VPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVE 289
           +P         +AEKIR+ +E+    W+ K + +T SIG+    A     + +F+ L  E
Sbjct: 336 LPHTTAEASRKIAEKIRQRLEVSDIRWEGKRIAVTASIGLSGTTAEE---SREFDSLYTE 392

Query: 290 ADTCLYRSKKDGRNRT 305
           AD  LY +K+ GRNR 
Sbjct: 393 ADKALYLAKQRGRNRV 408


>UniRef50_B4UA43 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Hydrogenobaculum
           sp. Y04AAS1 RepID=B4UA43_HYDS0
          Length = 610

 Score =  229 bits (584), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 55/187 (29%), Positives = 94/187 (50%), Gaps = 11/187 (5%)

Query: 125 PIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLD 181
            +     +     L + +  ++  D LT +Y+R  L + L+     + +  + L+V++ D
Sbjct: 432 AVFTFVDITKEKELSELLLKQSIEDTLTGIYNRRYLKDKLERHVNLAKRYERPLSVIMFD 491

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           ID+FK IND +GH+ GDKVL   ++ + + + +  + AR GGEEF +  P     D  ++
Sbjct: 492 IDFFKHINDTFGHDVGDKVLIAISKVVSENIRNTDIFARYGGEEFIIVAPETTKEDAKIL 551

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
           AEK+R  +    F   ++ + +T S GV S     L   D    L+   D  LY +K+ G
Sbjct: 552 AEKLRSLIRNLHF---EEGINVTCSFGVVS-----LEKPDTKETLLKRVDNALYEAKRTG 603

Query: 302 RNRTSTM 308
           RNR   +
Sbjct: 604 RNRVVVL 610


>UniRef50_Q7MRL2 Putative uncharacterized protein n=1 Tax=Wolinella succinogenes
           RepID=Q7MRL2_WOLSU
          Length = 480

 Score =  229 bits (584), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 82/293 (27%), Positives = 135/293 (46%), Gaps = 26/293 (8%)

Query: 21  LTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCL 80
           L LA+ G +   K E     + L    I  V++         L  L    + Y  +    
Sbjct: 201 LDLALSGRIAVDKRESNRKGLEL--GEIIEVLVS-------KLSTLAQAGIHYQDE---- 247

Query: 81  LTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIM--VSFSVAAINSL 138
           +T +   +E +++    ++ + G    I Q     +      +      + F  + I  L
Sbjct: 248 ITHIGKTLEEMILDPRSLEKTKGRLIEITQKIDTHIQNLNKEVAEKKSEIEFLQSKIEEL 307

Query: 139 MKQV---ALRADFDFLTQVYSRSGLYEAL---KSPSLKQTQHLTVMLLDIDYFKSINDNY 192
            +++      A  D LT V++R  L E+L   ++  L+     +V   DID+FK IND Y
Sbjct: 308 TQELCRAQEEASIDSLTGVHTRRFLEESLSRFEALFLRYESRYSVAFFDIDFFKKINDKY 367

Query: 193 GHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQ 252
           GHE GD+VL+ F R +++ V  + + AR GGEEF V +P +N V+    AE+IR  VE  
Sbjct: 368 GHEAGDRVLATFGRLLKQSVRQEDIAARYGGEEFIVILPEMNLVEAWRFAERIRALVERS 427

Query: 253 PFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
            F +Q   + ++VS G+        +  +D   L+  AD  LY +K+ GRN+ 
Sbjct: 428 VFVYQDMRIKVSVSGGIAE-----RSECEDRKALIKFADARLYEAKEGGRNQI 475


>UniRef50_Q2W1M0 Response regulator containing a CheY-like receiver domain and a
           GGDEF domain n=3 Tax=Magnetospirillum RepID=Q2W1M0_MAGSA
          Length = 477

 Score =  229 bits (584), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 57/194 (29%), Positives = 95/194 (48%), Gaps = 9/194 (4%)

Query: 117 GIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH-- 174
           G A   +  I +   +     +  Q+   A  D LT   +R   + A +    + +++  
Sbjct: 286 GTADEPMGTIGIVTDITERKHMESQLRHLATTDELTGCLNRRAFFVAAEQELERASRYGN 345

Query: 175 -LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSV 233
            ++V+++DID+FK +ND +GH  GDK L      I+  + +     R+GGEEFA  +P  
Sbjct: 346 AVSVLMIDIDHFKQVNDRHGHAVGDKALKAATAAIRANLREIDSFGRLGGEEFAAMLPET 405

Query: 234 NPVDGLLMAEKIRKGVELQPFTWQQK--TLYLTVSIGVGSGRASYLTLTDDFNKLMVEAD 291
                LL+AE++R+ VE            L LT S+GV   +   +      ++++  AD
Sbjct: 406 TLAGALLVAERLRQAVEAIALPLGDDQPPLRLTTSLGVAERQPGEVA----VDQVLARAD 461

Query: 292 TCLYRSKKDGRNRT 305
           T LYR+K +GRNR 
Sbjct: 462 TALYRAKAEGRNRV 475


>UniRef50_A8ZX32 Diguanylate cyclase n=1 Tax=Desulfococcus oleovorans Hxd3
           RepID=A8ZX32_DESOH
          Length = 396

 Score =  229 bits (584), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 76/336 (22%), Positives = 134/336 (39%), Gaps = 36/336 (10%)

Query: 4   DWFSEQFSTGVL----IVPCMLTLAIPGVLPRFKAEQMMPAIA-------LIVSVIASVV 52
           +WF       +L     V  +L   I     R + +   P +        +++    S  
Sbjct: 62  EWFDRSIVIALLSLYGFVFVLLLYFILAAFHRRRQKSSWPLMENIMFGSYVVIVCAGSWF 121

Query: 53  IGGA-----------GSLAFPLPALIWCAVRYTPQVTCLLTFV----TGAVEIVLVANSV 97
            G              S++  L  +    + Y      L+ F+    +G      +   +
Sbjct: 122 TGTYYTFGALFLFFGASISSSLADIRKVRLAYLASFGALVAFIVMDSSGMFRHAPLFTRI 181

Query: 98  IDISVGSPFSIPQMFSARLGIATMAICPI-MVSFSVAAINSLMKQVALRADFDFLTQVYS 156
                GSP  +       + ++   +  I +V+F    +   +      +  D LT++ +
Sbjct: 182 PLHPDGSPLPVWFGVQVFITVSLTIMLYITIVTFKRWGVREDV--YRKMSTVDGLTRLTN 239

Query: 157 RSGLYEA----LKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIV 212
           R    E     L S   + + H++ +++DID+FK+IND YGH  GDKVL   A  + +  
Sbjct: 240 RRTFIERSEKELSSGQRRPSSHISCIMIDIDHFKAINDTYGHAAGDKVLVKIATILTEKA 299

Query: 213 GDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSG 272
                V R GGEEFA+ +P+      + +AE+ R  +           + +T S GV S 
Sbjct: 300 RPTDEVGRYGGEEFAMLLPATTLAGAVKVAERQRASIANAEIIVDGNIIQVTASFGVASC 359

Query: 273 RASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
            +  +   D+ N+L+  AD  LY +K+ GRNR    
Sbjct: 360 PSDDI---DNINELLKTADVALYEAKRAGRNRVVAA 392


>UniRef50_B1KMS8 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Shewanella woodyi
           ATCC 51908 RepID=B1KMS8_SHEWM
          Length = 482

 Score =  229 bits (584), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 65/244 (26%), Positives = 110/244 (45%), Gaps = 8/244 (3%)

Query: 65  ALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAIC 124
            L + A +Y  +    +       + +L +   + +++ S  +I    +    I      
Sbjct: 230 PLTFIAKKYRLEYLSEIQKHISYDDTILDSRMDLTMTLPSNETIKVEMAFSTLIFEKKKL 289

Query: 125 PIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPS---LKQTQHLTVMLLD 181
            I     +     L  Q+ + A  D LT  Y+R    E  +       +Q Q  T++L+D
Sbjct: 290 VITAITDITERKRLETQLRILASTDPLTGAYNRRCFNELSQKSMSSTERQEQEFTILLID 349

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           +D+FKSIND +GH  GD VL    + I   + +  ++ R GGEEF VA+P+ +      +
Sbjct: 350 LDFFKSINDKFGHAAGDDVLIETVKAINTCIRESDILGRYGGEEFVVALPNSDNKKAREV 409

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
           A +IR  +E      Q   + LT SIG+ +    +        K + +ADT LY +K +G
Sbjct: 410 ANRIRLCIENMVVKTQGHDIKLTASIGLATSSGGH-----QLEKQINQADTYLYYAKDNG 464

Query: 302 RNRT 305
           RN+ 
Sbjct: 465 RNQV 468


>UniRef50_C8QVV3 Diguanylate cyclase n=1 Tax=Desulfurivibrio alkaliphilus AHT2
           RepID=C8QVV3_9DELT
          Length = 519

 Score =  229 bits (584), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 60/212 (28%), Positives = 98/212 (46%), Gaps = 13/212 (6%)

Query: 100 ISVGSPFSIPQMFSARLGIAT---MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYS 156
           ++        + F  RL +A    + I     +  +  +  L+++    A  D LT + +
Sbjct: 302 LAEIGQIGAEEDFGRRLPVAAGHEIGIIARHFNKLLEVVERLLREKDQLAGTDQLTGLNN 361

Query: 157 RSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVG 213
           R    E L    ++  +    L++++ DID+FK +ND YGHE GD VL   A+ +Q  V 
Sbjct: 362 RRRFKELLDQELIRYRRIPKPLSLLIFDIDHFKRVNDTYGHETGDLVLKEMAQLLQATVR 421

Query: 214 DKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGR 273
                AR GGEEF V +P+      + +AEK+R+ +E   F        +T S GV +  
Sbjct: 422 RTDTPARWGGEEFLVLLPATTAEAAMALAEKLRQAIEEHDFPRVG---RVTASFGVAAFH 478

Query: 274 ASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
                 +     L+   D  LY++K+ GRNR 
Sbjct: 479 DGEQEES----ALLRRVDKALYQAKRQGRNRV 506


>UniRef50_Q3AFS2 GGDEF domain protein n=1 Tax=Carboxydothermus hydrogenoformans
           Z-2901 RepID=Q3AFS2_CARHZ
          Length = 543

 Score =  229 bits (584), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 62/171 (36%), Positives = 98/171 (57%), Gaps = 7/171 (4%)

Query: 138 LMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGH 194
           L  ++   A  D LT +Y+R    E L    L+  +H    T++LLDIDYFK IND YGH
Sbjct: 371 LYLRLKELAQKDELTGLYNRRYFLERLNEEHLRSRRHKLNYTIVLLDIDYFKKINDTYGH 430

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
           +CGD VL+ F R ++  +    L AR GGEEF V +P     +  L+AE++R+ V+ +  
Sbjct: 431 DCGDLVLNDFGRFLKDTLRRTDLSARYGGEEFVVLLPQTGKKEAYLLAERLREKVKERVL 490

Query: 255 TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
            +Q + +  TVS+G+ +    Y    +++ +L+  AD  LY++K  GR++ 
Sbjct: 491 IFQGQKVKYTVSMGLAA----YPEDAEEYRELLSLADKALYQAKNRGRDKV 537


>UniRef50_C1SIQ7 Diguanylate cyclase (GGDEF) domain-containing protein n=1
           Tax=Denitrovibrio acetiphilus DSM 12809
           RepID=C1SIQ7_9BACT
          Length = 312

 Score =  229 bits (584), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 54/231 (23%), Positives = 105/231 (45%), Gaps = 8/231 (3%)

Query: 78  TCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINS 137
              +T  +   +IV          V  PF+  ++         +     ++      +  
Sbjct: 83  VIFITAKSEPEDIVKGFQMGGVDYVTKPFNEAELLMRINTHMELKRARDLLEEKNKELIE 142

Query: 138 LMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGH 194
              ++   A  D LT + +R  +   L   + +  ++    ++++ DID+FK +ND YGH
Sbjct: 143 AYDKIEHLALTDTLTGIANRRNITNMLGKEAARCKRNKGKFSLIMCDIDFFKRVNDTYGH 202

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
           + GD VL   +  IQ+ + ++ +VAR GGEEF + +P  +  + + +AEK+R  +     
Sbjct: 203 DAGDYVLKTISHVIQQALREQDIVARWGGEEFLIVLPETDAGNAVAVAEKLRTAIGNTEM 262

Query: 255 TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
           +++  +  +T++ GV     S         K + +AD  LY  K+ GRN+ 
Sbjct: 263 SYEGISFSVTMTFGVSEYDVSL-----GIEKSIKKADDALYEGKQTGRNKV 308


>UniRef50_UPI000185121C diguanylate cyclase n=1 Tax=Bacillus coahuilensis m4-4
           RepID=UPI000185121C
          Length = 466

 Score =  229 bits (584), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 59/187 (31%), Positives = 95/187 (50%), Gaps = 7/187 (3%)

Query: 126 IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVMLLDI 182
           +++   +  + +L  Q+   A +D LT +Y+R   +   E     S +Q    T++L+DI
Sbjct: 277 LIIFTDMTEVKNLQSQLEHFAYYDELTGIYNRRAFFQYCEEAFQESKEQDTPFTIILMDI 336

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           DYFK +ND YGH  GD+VL   A+  Q  +    L AR GGEEF + V      +G  +A
Sbjct: 337 DYFKKVNDTYGHSVGDQVLEQVAKVCQSQLHGHELFARYGGEEFVLGVKGYTEEEGAALA 396

Query: 243 EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           E++R  VE          + +T+S+GV +         +   +++  AD  LYR+K+ GR
Sbjct: 397 EQLRSEVEALTIHTPDGKITVTLSLGVAALTKE----DEALYQILNHADQALYRAKEAGR 452

Query: 303 NRTSTMR 309
           NR    +
Sbjct: 453 NRVCVYQ 459


>UniRef50_Q67JR0 Putative uncharacterized protein n=1 Tax=Symbiobacterium
           thermophilum RepID=Q67JR0_SYMTH
          Length = 425

 Score =  229 bits (584), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 54/183 (29%), Positives = 88/183 (48%), Gaps = 7/183 (3%)

Query: 128 VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYE---ALKSPSLKQTQHLTVMLLDIDY 184
           V   ++A   L   +   A  D LT  Y+R    E        + ++ +  +++L+DID+
Sbjct: 223 VFRDISARKRLESDLKHLATTDGLTGAYNRRSFVEVCGQELQRADRRARPTSLLLMDIDH 282

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEK 244
           FK +ND +GH  GD+VL       ++++  + +V R+GG+EFAV +P+        +AE+
Sbjct: 283 FKRLNDRFGHAAGDEVLRQIVETGRRVLRSEDVVGRIGGDEFAVLLPATTLEQAGRVAEQ 342

Query: 245 IRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           +R   E      +  T   TVS GV   +    T      +L+  AD  LY +K  GRN 
Sbjct: 343 LRTTYERLAVPARGGTATFTVSFGVAEWKPHLRT----VEELLQRADRALYAAKNAGRNC 398

Query: 305 TST 307
             T
Sbjct: 399 VRT 401


>UniRef50_C6P3N4 Diguanylate cyclase n=1 Tax=Sideroxydans lithotrophicus ES-1
           RepID=C6P3N4_9PROT
          Length = 387

 Score =  228 bits (583), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 80/314 (25%), Positives = 137/314 (43%), Gaps = 20/314 (6%)

Query: 11  STGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGA--GSLAFPLPALIW 68
           S+ VLI+  +         PR++    +    LI +++   + G    G + F L  ++ 
Sbjct: 77  SSYVLILAAVYEFQQRSA-PRWQYFVPVILTLLIAAILIDDIHGRFIWGGIVFVLQLVLI 135

Query: 69  CAVRYTPQVT------CLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMA 122
            +     + T       LL      V +VL   S++ +S     + P+       +  ++
Sbjct: 136 ASELLRNRATHTGRAWRLLLAGIAIVVVVLGLRSLVAMSGQFILAQPETGGVPNWVQVLS 195

Query: 123 ICPIMVS-------FSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP-SLKQTQH 174
              +M S       F +       ++V   A  D LT V +R  L +  +   + +  + 
Sbjct: 196 FVAVMASSLLGSIGFLLMVKERTDREVLHLAMTDSLTGVPNRRALMDYAERAMAQRGGRS 255

Query: 175 LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVN 234
           + ++++D D+FK IND YGH  GD+VL    R +Q+ +    L+ R GGEEF V  P  +
Sbjct: 256 VALLMIDADHFKRINDTYGHPVGDEVLRQLTRLLQQRLRGGDLLGRYGGEEFCVVAPDAD 315

Query: 235 PVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCL 294
               L +AE +R+ V       +Q  L +TVSIG+    A           ++ EAD  L
Sbjct: 316 AEGALKLAESLRESVASAVLDTEQGKLSITVSIGIAHSTA---DAGRALKDILAEADIAL 372

Query: 295 YRSKKDGRNRTSTM 308
           Y +KK GRN+  + 
Sbjct: 373 YSAKKGGRNQVVSF 386


>UniRef50_B0C2A6 Diguanylate cyclase (GGDEF domain), putative n=3 Tax=Acaryochloris
           marina MBIC11017 RepID=B0C2A6_ACAM1
          Length = 420

 Score =  228 bits (583), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 61/186 (32%), Positives = 102/186 (54%), Gaps = 9/186 (4%)

Query: 133 AAINSLMKQVALRADFDFLTQVYSRSGLYEALKS---PSLKQTQHLTVMLLDIDYFKSIN 189
             ++   KQ++L A+ D LT + +R    E L+     + ++ Q L++++ DID+FK  N
Sbjct: 238 KKLDEANKQLSLIANHDALTGLANRRRFDEYLQQIWKQTQREQQPLSLLICDIDFFKQYN 297

Query: 190 DNYGHECGDKVLSVFARHI-QKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKG 248
           D YGH  GD  L   A+ I Q IV    LVAR GGEEFA+ +P+ +   G ++AE++R  
Sbjct: 298 DTYGHLEGDICLRTVAQKIHQTIVRPLDLVARFGGEEFAIVLPNTDLEGGQVVAERLRMI 357

Query: 249 VELQPFTWQQKTLY--LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
           ++      +  ++   +TVSIG  + R+   T     + L+  AD  LY++K+ GR++  
Sbjct: 358 IQKSQLPHRGSSVSEFVTVSIGAATVRSHPHT---SVSSLISRADQALYQAKQSGRDQVV 414

Query: 307 TMRYGE 312
            +   E
Sbjct: 415 ALSITE 420


>UniRef50_B8DJ36 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfovibrio
           vulgaris str. 'Miyazaki F' RepID=B8DJ36_DESVM
          Length = 698

 Score =  228 bits (583), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 59/172 (34%), Positives = 87/172 (50%), Gaps = 7/172 (4%)

Query: 141 QVALRADFDFLTQVYSRSGLYEALKSPS---LKQTQHLTVMLLDIDYFKSINDNYGHECG 197
           ++   A  D LT V +R      L+  +    +  + L+V+LLD D+FKSIND +GHE G
Sbjct: 506 RLEQLATTDELTGVANRRHFMARLEDEAARAQRYGRPLSVLLLDADHFKSINDTWGHEAG 565

Query: 198 DKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ 257
           D VL      +   + +  L+ R+GGEEF V +P       L  AE+IR  VE  P   +
Sbjct: 566 DMVLRHITDVMGLSLRENDLIGRLGGEEFGVLLPETAQERALRTAERIRAAVEDAPVAVR 625

Query: 258 QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
              +  TVS+G    R +     D  + L+  AD  L R+K++GRNR    +
Sbjct: 626 DVWVGCTVSVGAAEYRGA----NDSLDDLIRRADHMLMRAKEEGRNRVCAQQ 673


>UniRef50_Q02P32 Putative two-component response regulator n=6 Tax=Pseudomonas
           aeruginosa RepID=Q02P32_PSEAB
          Length = 525

 Score =  228 bits (583), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 61/187 (32%), Positives = 103/187 (55%), Gaps = 8/187 (4%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVMLL 180
             ++  + ++   ++ +++ L A  D LT +++R       E +   + +       ++L
Sbjct: 339 ATLIWCYDISRRKAMEQELRLLASTDTLTGLHNRHSFLHQAELMLKAAERFRHPCVALML 398

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DID+FK+IND++GH  GD+ L   A  +++ + +  L+ R+GGEEFA  +P V+    L 
Sbjct: 399 DIDHFKNINDSHGHLTGDRALQRVAETLRQGLREVDLLGRLGGEEFAALLPEVSLDQALD 458

Query: 241 MAEKIRKGVELQPFTW-QQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKK 299
           +AE++R GVE    +    + L +TVSIGV   R       DD   L+V AD+ LY++K 
Sbjct: 459 VAERLRAGVEALRVSNPDGEPLRMTVSIGVALRR----DAGDDLESLLVRADSALYQAKS 514

Query: 300 DGRNRTS 306
            GRNRT 
Sbjct: 515 GGRNRTE 521


>UniRef50_Q7NZV8 Putative uncharacterized protein n=1 Tax=Chromobacterium violaceum
           RepID=Q7NZV8_CHRVO
          Length = 383

 Score =  228 bits (583), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 57/171 (33%), Positives = 93/171 (54%), Gaps = 7/171 (4%)

Query: 139 MKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHE 195
            KQ+   A  D LT++ +R    E       +  +H   ++V+++D+D+FK IND+YGH 
Sbjct: 209 EKQLYRLATQDGLTELNNRRQFIELADREIERSRRHGSRMSVLMMDLDHFKDINDHYGHA 268

Query: 196 CGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFT 255
            GD+V+  F++  ++++    L  R+GGEEFA  +P     D   +AE++R        +
Sbjct: 269 VGDEVIRHFSQVCREVLRASDLCGRLGGEEFAAVLPDTGLDDARQVAERLRSLASSARLS 328

Query: 256 WQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
               +L  TVSIGV    A       D ++++  AD  LY++K+DGRNR S
Sbjct: 329 AVSGSLGYTVSIGVAERHADET----DIDEVLGRADKQLYQAKRDGRNRVS 375


>UniRef50_Q3JE99 Response regulator receiver modulated diguanylate cyclase n=2
           Tax=Nitrosococcus oceani RepID=Q3JE99_NITOC
          Length = 661

 Score =  228 bits (581), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 64/244 (26%), Positives = 108/244 (44%), Gaps = 16/244 (6%)

Query: 74  TPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAI--------CP 125
                 +LT +    E + +  +  D  +  PF+  ++  AR+G     I          
Sbjct: 394 RQIYLIVLTGMVSGGEAIRIFEAGADDHIAKPFNY-EVLQARVGGGERLIRLREEAEQER 452

Query: 126 IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKS---PSLKQTQHLTVMLLDI 182
             V   +A +    +++   A  D LT + +R    E ++       +     + +++D+
Sbjct: 453 EAVRGYLADLAVANRRLGQMAMTDSLTGLPNRRYAMERMEQAWAEYERNQTPFSCLVMDL 512

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           D+FK +ND YGHE GD VL   A   +       ++ R+GGEEF V  P     +   +A
Sbjct: 513 DFFKRVNDQYGHEIGDSVLLEIANVFRGSARSSDIICRLGGEEFLVVCPHTVATEAFQVA 572

Query: 243 EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           E++R+ VE   +T    T  L+VSIG+ +         D    L   AD  LY++K++GR
Sbjct: 573 ERLRRAVEEHSWTMLDSTSVLSVSIGLAASSEGMQHWND----LYRLADQALYQAKRNGR 628

Query: 303 NRTS 306
           NR  
Sbjct: 629 NRVC 632


>UniRef50_Q0BZW4 Response regulator PleD n=1 Tax=Hyphomonas neptunium ATCC 15444
           RepID=Q0BZW4_HYPNA
          Length = 455

 Score =  228 bits (581), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 59/199 (29%), Positives = 98/199 (49%), Gaps = 9/199 (4%)

Query: 115 RLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQ 171
           R  +A         +  +  +   + +    +  D LT +++R  +    E     + + 
Sbjct: 259 RQELAARIRTQTRRTRYIDILRQRVDRGLELSVIDQLTGLHNRRYMNGQLEQFMQRAARG 318

Query: 172 TQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVP 231
            Q L++M+ DID+FK++ND +GH+ GD VL    + ++  V    +V R GGEEF V +P
Sbjct: 319 NQPLSLMMTDIDHFKAVNDTHGHQAGDDVLREIGKRLRANVRPTDVVCRTGGEEFVVLMP 378

Query: 232 SVNPVDGLLMAEKIRKGVELQPFTWQQKT--LYLTVSIGVGSGRASYLTLTDDFNKLMVE 289
           +         AE+IRK V  + F     +  L +TVS GV + + +     D  + LM  
Sbjct: 379 NTPGDLACAAAERIRKAVAAEEFPVLGGSQNLRITVSAGVSTLQGA----GDTTDDLMHR 434

Query: 290 ADTCLYRSKKDGRNRTSTM 308
           ADT LY++K  GRNR  ++
Sbjct: 435 ADTALYQAKTGGRNRVESI 453


>UniRef50_Q8DCJ9 FOG: GGDEF domain n=3 Tax=Vibrio RepID=Q8DCJ9_VIBVU
          Length = 479

 Score =  228 bits (581), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 63/220 (28%), Positives = 104/220 (47%), Gaps = 7/220 (3%)

Query: 91  VLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDF 150
           +  A+ ++ +       I   FS  +      I  IM    ++    L   +   A  D 
Sbjct: 258 IARADLLLMLPEKKDIPIEMAFSRLVFEGKPMI--IMSITDISERKKLEAMLRNLAATDP 315

Query: 151 LTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARH 207
           LT  ++R    E  +       +    L++M+LDID+FK  ND+YGH  GD VL    + 
Sbjct: 316 LTGAFNRRSFMEQAEKSIRTCQRWNCPLSIMILDIDHFKQFNDSYGHAAGDLVLVELVKM 375

Query: 208 IQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSI 267
                 +  ++ R+GGEEFAV +P +   +   +A+++R  VE     ++Q+ L +T+SI
Sbjct: 376 ADLSTREIDIIGRLGGEEFAVVLPGLGEKEAFEVAKRLRSVVENMQVNYEQQPLQMTISI 435

Query: 268 GVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
           GV + + S L       +LM +AD  LY +K  GRN   +
Sbjct: 436 GVATLQPSELNTP--LEQLMKQADEGLYYAKAHGRNCVIS 473


>UniRef50_Q315M6 Diguanylate cyclase n=1 Tax=Desulfovibrio desulfuricans subsp.
           desulfuricans str. G20 RepID=Q315M6_DESDG
          Length = 403

 Score =  228 bits (581), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 73/302 (24%), Positives = 133/302 (44%), Gaps = 12/302 (3%)

Query: 18  PCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSL---AFPLPALIWCAVRYT 74
            C+L   +        A     A+ + + V+    +    +     F LP   +      
Sbjct: 99  YCVLYFFLRTSGMLKVASDFALALTVTLGVLLIWRLNDQIAYILWLFALPPAAFFTFGTK 158

Query: 75  PQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATM-AICPIMVSFSVA 133
                L   +   +    V+ + +     S     ++ +A   ++   A+     + +  
Sbjct: 159 RAAVALGLLLIALLLSPFVSPAAMPPETFSLSYFVRVIAAFFTLSLFSALGEYSRAHTQR 218

Query: 134 AINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSIND 190
            + +L +++   A  D LT + +R G+Y+ L     + T+     +V+L D+D+FK++ND
Sbjct: 219 TLVALTREMEQCACTDPLTGLLNRRGIYDRLNEERARATRSGSTFSVILCDVDHFKNVND 278

Query: 191 NYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVE 250
            +GH+CGD VL   A H ++ V  + +V R GGEEF   +P  +    L +AEK+R  VE
Sbjct: 279 CFGHQCGDHVLHQLAEHFRRSVRGQDVVCRWGGEEFLFILPETDEQGALNLAEKLRSTVE 338

Query: 251 LQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRY 310
             P  +    + +T+S+GV        TLT+     +  AD  LY +K+ GRN+  +   
Sbjct: 339 QTPVNYHGMPIDITLSLGV-----QECTLTESTEFHIRVADQKLYIAKEHGRNKVVSGNI 393

Query: 311 GE 312
            E
Sbjct: 394 EE 395


>UniRef50_C6P6Y5 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Sideroxydans
           lithotrophicus ES-1 RepID=C6P6Y5_9PROT
          Length = 671

 Score =  228 bits (581), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 61/207 (29%), Positives = 97/207 (46%), Gaps = 9/207 (4%)

Query: 108 IPQMFSARLGIATMAICPIMVSF-SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKS 166
           +P   S    I       I+V+F  +       +++  RA  D LT + +R   YE  + 
Sbjct: 469 LPISVSVSAIIREQQAAGIVVAFHDITERKKFEQELERRAQIDALTSLNNRRHFYELAEQ 528

Query: 167 PSLK---QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGG 223
             L+     + L +M+LD+D+FK IND YGH  GD VL        + + +  ++ R+GG
Sbjct: 529 EILRTKRYGKPLALMMLDVDHFKDINDTYGHHVGDTVLQTLGAVCLQTMREIDIIGRLGG 588

Query: 224 EEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ-QKTLYLTVSIGVGSGRASYLTLTDD 282
           EEFA+ +P          AE++R  V       +  +TL  T+SIGV    A       D
Sbjct: 589 EEFAILLPEATAAQAFDAAERLRLAVAAIAMPLEQGQTLSFTISIGVTGLVA----KDSD 644

Query: 283 FNKLMVEADTCLYRSKKDGRNRTSTMR 309
              ++  AD  +Y++K+ GRNR  +  
Sbjct: 645 IADMLKRADEAMYQAKRSGRNRVCSQE 671


>UniRef50_C0QPI4 Response regulator n=1 Tax=Persephonella marina EX-H1
           RepID=C0QPI4_PERMH
          Length = 615

 Score =  227 bits (580), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 79/254 (31%), Positives = 117/254 (46%), Gaps = 27/254 (10%)

Query: 64  PALIWCAVRYTP-QVTCLLTFVTGAVEIVLVA----NSVIDISVGSPFSIPQMFSARLGI 118
           P  I C         TC+  +V G V I+L       S ++I    PF       A L  
Sbjct: 372 PNFIKCENGEAEEFFTCIPIYVGGRVGIILQLIYDKESRVNIKNKLPF-----IEAYLRE 426

Query: 119 ATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYE---ALKSPSLKQTQHL 175
               I             S M+++  ++  D LT +Y+R  L E    L   ++++   +
Sbjct: 427 VAPVI----------EAKSYMEKLRKQSLVDQLTGLYNRRFLEELIPKLSQQTIRRKSTI 476

Query: 176 TVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNP 235
            ++++D+D+FK +ND YGH+ GD VL   A  + K V +  +V R GGEEF V +  V  
Sbjct: 477 GILMVDVDFFKQVNDQYGHDVGDTVLKRVADILNKSVREADIVVRYGGEEFIVLLVDVEK 536

Query: 236 VDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLY 295
              + +AEKIRK VE         TL  TVSIGV      +   +D F + +  AD  LY
Sbjct: 537 GKSVEIAEKIRKKVENMVIHTDGVTLKKTVSIGVSE----FPHDSDRFWQCIKFADIALY 592

Query: 296 RSKKDGRNRTSTMR 309
           R+K+ GRN+     
Sbjct: 593 RAKETGRNKVVRFE 606


>UniRef50_Q2BP61 GGDEF/HAMP domain protein n=1 Tax=Neptuniibacter caesariensis
           RepID=Q2BP61_9GAMM
          Length = 580

 Score =  227 bits (580), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 58/184 (31%), Positives = 89/184 (48%), Gaps = 7/184 (3%)

Query: 128 VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDY 184
           +   V A     +++   A  D LT+V +R    +  +     S +  + L ++LLDID+
Sbjct: 395 LQLEVNARKKAEEELIKLASTDPLTRVLNRRAFDQRSREEIERSHRYNRELAIILLDIDH 454

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEK 244
           FK IND YGH+ GDKVL   A  I   +     + R GGEEF + +P  +    LL+AE+
Sbjct: 455 FKQINDQYGHQFGDKVLIDVANLIGPSLRAADCLCRHGGEEFIILLPETDEATALLIAER 514

Query: 245 IRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           +RK +     T +  +L +T S GV   R        D    +  AD  +Y++K  GRN+
Sbjct: 515 VRKSIAQHKITDRHDSLSITASFGVAVWRRE----EGDIQPAVYRADQAMYKAKNSGRNK 570

Query: 305 TSTM 308
               
Sbjct: 571 VVAF 574


>UniRef50_Q4ZZT3 GGDEF n=5 Tax=Pseudomonas syringae group RepID=Q4ZZT3_PSEU2
          Length = 690

 Score =  227 bits (580), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 59/171 (34%), Positives = 97/171 (56%), Gaps = 8/171 (4%)

Query: 139 MKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGHE 195
           +++   +A  D LT + +R+   E L+    +  +    L V +LD+D+FK IND YGH 
Sbjct: 523 LEEQRQKALIDPLTGLPNRAAWGERLEREMARWHEEKNSLLVCILDLDHFKRINDGYGHL 582

Query: 196 CGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFT 255
            GDKVL + A  + K +     +AR GGEEF + +P+  P  GL + +++R  VE  PF 
Sbjct: 583 AGDKVLKIVANVLSKRLRADDFMARFGGEEFVMLLPATPPATGLKLLDELRAAVESCPFH 642

Query: 256 WQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
           ++ + + +TVSIG+ + R S  +     +  +  AD  LY++K++GRNR  
Sbjct: 643 FKGERVTITVSIGMTAFRPSERS-----DTAIKRADQALYKAKENGRNRIE 688


>UniRef50_Q31EI0 Diguanylate cyclase (GGDEF domain) n=1 Tax=Thiomicrospira crunogena
           XCL-2 RepID=Q31EI0_THICR
          Length = 620

 Score =  227 bits (580), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 52/184 (28%), Positives = 91/184 (49%), Gaps = 10/184 (5%)

Query: 127 MVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDID 183
           ++   +        Q+      D LT VY+R      L+    +  +     ++  +DID
Sbjct: 438 VLMTDITEEEHYKSQLEHLIIHDELTGVYNRHYFNRTLEQEIKRHQRYQSPFSMAFMDID 497

Query: 184 YFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAE 243
           +FK IND YGH+ GD VL   A++I  ++    +  R+GGEEF + +P  +  + L+++E
Sbjct: 498 HFKMINDTYGHDVGDAVLVSLAKNISSLLRSTDVFCRVGGEEFVIMMPETSLENALIISE 557

Query: 244 KIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           +IR  VE    + +     +T+S+G+    +      D+       AD  LY++K++GRN
Sbjct: 558 RIRSTVEG--ISSKDVPEKITISMGLVELNSW-----DNVQSFYKRADEALYKAKENGRN 610

Query: 304 RTST 307
           R  T
Sbjct: 611 RIET 614


>UniRef50_C0Z6I5 Putative uncharacterized protein n=1 Tax=Brevibacillus brevis NBRC
           100599 RepID=C0Z6I5_BREBN
          Length = 530

 Score =  227 bits (580), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 58/184 (31%), Positives = 94/184 (51%), Gaps = 8/184 (4%)

Query: 127 MVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFK 186
            + F++  I    +Q+   A  D LT + +R  L E ++    +Q    ++M++D+D FK
Sbjct: 354 AIRFALTNIKKKTEQLTHDARTDPLTGLTNRRTLEETMQKWMAEQ-IPFSIMMMDLDRFK 412

Query: 187 SINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIR 246
           +IND YGH+ GD+VL  FA+ I   +  + +  R GGEEF V V      +   +AE+IR
Sbjct: 413 AINDTYGHQAGDEVLRHFAKIISSSLRPEDVSCRFGGEEFVVLVSHTGLEEAYQVAERIR 472

Query: 247 KGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
           + +E +     Q    LTVS G+      Y +       L+  AD  +Y++K+ GRN+T 
Sbjct: 473 RALETRTNPIGQ---RLTVSQGIA----HYPSHAVSPEGLLHVADEAMYKAKRAGRNQTM 525

Query: 307 TMRY 310
               
Sbjct: 526 IAEE 529


>UniRef50_Q479Y1 GGDEF n=1 Tax=Dechloromonas aromatica RCB RepID=Q479Y1_DECAR
          Length = 413

 Score =  227 bits (580), Expect = 4e-58,   Method: Composition-based stats.
 Identities = 61/228 (26%), Positives = 104/228 (45%), Gaps = 13/228 (5%)

Query: 83  FVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQV 142
            +       L  + + D +     S   M  +   I  MA   +M++     +     ++
Sbjct: 163 LLIRPWLFSLGKSGLFDAAQAIAVSQFVMVESIAAIVLMAFGIVMLANEQVTL-----EL 217

Query: 143 ALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDK 199
              A+ D LT V++R      L    S S +    L++ML+D+D+FK IND +GH+ GD+
Sbjct: 218 RAIAERDPLTGVFNRRSFLTLLDKSISHSDRMASPLSIMLIDLDHFKKINDTWGHKSGDE 277

Query: 200 VLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQK 259
            L  F       + +  ++ R+GGEEFA+ +P  +      +AE++R  V  +P   +  
Sbjct: 278 ALRHFVAVAVPCIRNGDIIGRVGGEEFAILLPDTDISKAATVAERLRCEVAARPVKNEHG 337

Query: 260 TLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
           ++ LTVSIGV   R       +     +  AD  +Y +K  GRN+   
Sbjct: 338 SITLTVSIGVTHYR-----KDEAPEVTLHRADNAMYTAKDKGRNQVEV 380


>UniRef50_B7VQN9 GGDEF family protein n=1 Tax=Vibrio splendidus LGP32
           RepID=B7VQN9_VIBSL
          Length = 405

 Score =  227 bits (580), Expect = 4e-58,   Method: Composition-based stats.
 Identities = 72/271 (26%), Positives = 130/271 (47%), Gaps = 18/271 (6%)

Query: 41  IALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDI 100
             + +  +ASV++   G++A    AL+     ++     +L  +      + +    ID 
Sbjct: 129 FYITLCTVASVLVIKTGTVADVKAALVLLMSVFSAHSIFMLVRIW-----ITLKEPNIDD 183

Query: 101 SVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGL 160
            + +  SI Q+      I  + +  I  +++      LM+ +   +  D LTQ+Y+R  +
Sbjct: 184 FLQAS-SIHQLA---FIITAILLSTIGFTYNWLLNARLMQSLYSSSMKDSLTQLYNRRAM 239

Query: 161 YEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGL 217
            E L+     S++    L+V++LDID+FK +ND +GH+ GD+VL      +Q  +    +
Sbjct: 240 NEMLRREWMRSVRHNHPLSVIILDIDHFKQVNDQHGHQTGDQVLKKIGIILQHNLRAADI 299

Query: 218 VARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYL 277
             R GGEEF + +P     +   +AEK+R  +E   F W+Q++  LT S G+    A   
Sbjct: 300 PFRYGGEEFLIVLPDTRIGEACKVAEKLRIIIEETKF-WRQQSANLTASFGLSELWAE-- 356

Query: 278 TLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
              D    ++  AD  LY +K++GRN    +
Sbjct: 357 ---DKVPSMIKRADEALYYAKENGRNTVCAL 384


>UniRef50_C6DCR6 Diguanylate cyclase n=6 Tax=Pectobacterium RepID=C6DCR6_PECCP
          Length = 532

 Score =  227 bits (580), Expect = 4e-58,   Method: Composition-based stats.
 Identities = 56/181 (30%), Positives = 101/181 (55%), Gaps = 8/181 (4%)

Query: 127 MVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFK 186
           ++ F    ++  + +++L+A  D LT + +R G+YE+++    K  Q +  +++DID+FK
Sbjct: 347 VILFGTLLLHKRIGKLSLQAHTDPLTGLLNRRGIYESIELILPKSNQ-VAAIVIDIDHFK 405

Query: 187 SINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIR 246
            +ND YGH  GD V+ + A+ I++   +  L+ R GGEEF   +P  +    + +AE++R
Sbjct: 406 RVNDTYGHNIGDDVIRLLAKSIKQGSRESDLICRTGGEEFLALLPDTDMKQAVDIAERLR 465

Query: 247 KGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
           K VE  P    +    +T+S+GV           +  + ++  AD  LY++K +GRNR  
Sbjct: 466 KKVEKMPLPIPE---NITISLGVTCFIPG----AEQIDNVLKIADDALYQAKHEGRNRVV 518

Query: 307 T 307
           T
Sbjct: 519 T 519


>UniRef50_A5UZW7 Diguanylate cyclase with GAF sensor n=2 Tax=Roseiflexus
           RepID=A5UZW7_ROSS1
          Length = 797

 Score =  227 bits (579), Expect = 5e-58,   Method: Composition-based stats.
 Identities = 60/226 (26%), Positives = 108/226 (47%), Gaps = 8/226 (3%)

Query: 91  VLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDF 150
           V+  + ++ +           FS R G A + I       ++     L  +    A  D 
Sbjct: 576 VVAGDRMLGVLAVYHLHDHSHFSERDG-AMLEIVGRQTGIAITNA-QLFTETQRLATTDQ 633

Query: 151 LTQVYSRSGLYE---ALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARH 207
           LT +++R   +         + +    + ++++D+D+FK+IND YGH  GD VL   A H
Sbjct: 634 LTGLFNRYHFFALAPRELERARRYRHDVALLIIDVDHFKTINDTYGHVAGDTVLQHIADH 693

Query: 208 IQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSI 267
           +++ + D  ++AR GGEEF   +P  N    L +A ++R  +E  P     +++  T+S+
Sbjct: 694 MRRELRDADILARFGGEEFIALLPETNLTGALRVAGRLRATIEANPVPLNGQSIRATISV 753

Query: 268 GVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST-MRYGE 312
           G  S   +  T  +  + L+  AD  LY +K  GRN+ ++   YG+
Sbjct: 754 GCASLHPA--TRDEHLDTLIQRADRALYTAKAGGRNQVASDASYGD 797


>UniRef50_B7K319 Response regulator receiver modulated diguanylate cyclase n=2
           Tax=Cyanothece RepID=B7K319_CYAP8
          Length = 660

 Score =  227 bits (579), Expect = 5e-58,   Method: Composition-based stats.
 Identities = 66/212 (31%), Positives = 111/212 (52%), Gaps = 16/212 (7%)

Query: 105 PFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEAL 164
             S+ +  +A+LGIA      I  S  +  +    +++A  A+ D LTQV +R    E L
Sbjct: 454 EMSLLESVAAQLGIA------IAHSHLLEQLKEANEKLAALANLDGLTQVANRRHFDEIL 507

Query: 165 KSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIV-GDKGLVAR 220
                   ++ Q L++++ D+DYFK  ND YGH+ GD+ L   A+ I K V     LVAR
Sbjct: 508 AQRWKQCAREKQPLSLIMCDVDYFKRYNDFYGHQMGDECLIKVAQTIAKTVQRPGDLVAR 567

Query: 221 MGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY--LTVSIGVGSGRASYLT 278
            GGEEFAV +P+ +      +A+ IR+ V+      +   +   +++S+G+ +      T
Sbjct: 568 WGGEEFAVILPNTDVNGVKYIAQSIREQVQSLAIIHEDSPIKNQVSISLGIATIIPPAKT 627

Query: 279 LTDDFNKLMV----EADTCLYRSKKDGRNRTS 306
           L ++   L+     +AD  LY++K+ GR+R +
Sbjct: 628 LENNHESLIKALIAQADQALYQAKEQGRDRIA 659


>UniRef50_A0YVG8 GGDEF/response regulator receiver domain protein n=1 Tax=Lyngbya
           sp. PCC 8106 RepID=A0YVG8_9CYAN
          Length = 329

 Score =  227 bits (579), Expect = 5e-58,   Method: Composition-based stats.
 Identities = 58/245 (23%), Positives = 108/245 (44%), Gaps = 21/245 (8%)

Query: 78  TCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINS 137
              LT       ++          +  PF  P++ +            + + ++   +N 
Sbjct: 84  VIFLTASEEKEHLLEAFKQGAVDYITKPFYAPELLAR-------VRVHLELKYTKDELNK 136

Query: 138 LMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVMLLDIDYFKSINDNYGH 194
                  +A  D LT +++R  L    E     ++   +  ++++LDID+FK +ND YGH
Sbjct: 137 KSAAFEKQAITDPLTGIFNRRHLMSISEIEYQKAVNYNRLFSIIMLDIDHFKKVNDTYGH 196

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
             GD+VL    + +Q ++ +  +  R GGEEFA+ +P  +    L +AE++R+ +     
Sbjct: 197 IVGDQVLKRMTQEVQNLLREGDVCGRFGGEEFAIILPGADLKIALKIAERLRQAIADFYI 256

Query: 255 TWQQK------TLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST- 307
                       + +T+S+GV +    Y    D  +K+   AD  LY++K  GRN+  + 
Sbjct: 257 PIYDSNSSSNLKIKITISLGVTT----YHIDDDKLDKMWRRADDALYQAKAKGRNQVCSI 312

Query: 308 MRYGE 312
              GE
Sbjct: 313 YEPGE 317


>UniRef50_Q314F9 Diguanylate cyclase (GGDEF domain) n=1 Tax=Desulfovibrio
           desulfuricans subsp. desulfuricans str. G20
           RepID=Q314F9_DESDG
          Length = 542

 Score =  227 bits (579), Expect = 5e-58,   Method: Composition-based stats.
 Identities = 60/184 (32%), Positives = 94/184 (51%), Gaps = 3/184 (1%)

Query: 130 FSVAAINSLMKQVALRADFDFLTQVYSRSGLYE---ALKSPSLKQTQHLTVMLLDIDYFK 186
           F    ++  M+ +   +  D LT +++R  L        +   +     + ++LDID+FK
Sbjct: 350 FMAERVSQQMRDLEHLSFCDTLTGLHNRRHLAHEGTRTITACTEADLPCSCLMLDIDFFK 409

Query: 187 SINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIR 246
            +ND +GH+ GD VL   AR I   V  K +  RMGGEEFAV  P+ +      +AE+IR
Sbjct: 410 QVNDAWGHDAGDMVLQSVARTISNAVRSKDMTIRMGGEEFAVIAPATDTASAFSLAERIR 469

Query: 247 KGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
           + +E  P       + +T+SIGV     + +  T   + L+ +AD  LY++KK GRNRT 
Sbjct: 470 RNIESTPVQAADDEIRITISIGVADMGGAPIFGTTQLDDLLAKADRALYQAKKKGRNRTE 529

Query: 307 TMRY 310
               
Sbjct: 530 IWSE 533


>UniRef50_Q47Y21 GGDEF domain protein n=1 Tax=Colwellia psychrerythraea 34H
           RepID=Q47Y21_COLP3
          Length = 722

 Score =  226 bits (578), Expect = 5e-58,   Method: Composition-based stats.
 Identities = 69/283 (24%), Positives = 123/283 (43%), Gaps = 16/283 (5%)

Query: 31  RFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEI 90
           + K E  +  +A+++ ++ ++    A  L + + + +        ++T  L  ++     
Sbjct: 451 KLKKEGYLIILAMLIFLLVAIFF--ALVLNYSIISPV-------RKLTYALNDMSEGQNN 501

Query: 91  VLVANSVIDISVGS-PFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFD 149
           +   +      +GS   +  ++    L               +    S        A  D
Sbjct: 502 IHFNHIDSKDEIGSMQLAFEKLRRKLLQGDVYKATVSQQQKEIKYRKSQQDHFQQLALTD 561

Query: 150 FLTQVYSRSGLYEALKSPSLK---QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFAR 206
            LT   +R    E L             L++MLLDID+FKS+ND YGH  GD+VL +F +
Sbjct: 562 ALTGAVNRHHFNEVLDQEIANVNNHGSPLSIMLLDIDHFKSVNDRYGHGVGDEVLVMFYQ 621

Query: 207 HIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVS 266
              + V    +VAR+GGEEF + +P+   V+    AE++R+ +           + +TVS
Sbjct: 622 TCVEAVRSSDVVARIGGEEFVIIMPNTQLVNAQKFAERLRQKIAKLELNIANNQISVTVS 681

Query: 267 IGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
           IGV   ++ Y T  + F   +  AD  LY++K  GRN+    +
Sbjct: 682 IGVSQWQSEYFTNAETF---VAHADKSLYQAKNSGRNKVVVAQ 721


>UniRef50_Q1D632 GAF domain/GGDEF domain protein n=2 Tax=Cystobacterineae
           RepID=Q1D632_MYXXD
          Length = 710

 Score =  226 bits (578), Expect = 6e-58,   Method: Composition-based stats.
 Identities = 60/194 (30%), Positives = 107/194 (55%), Gaps = 8/194 (4%)

Query: 118 IATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQH 174
           +  + +  I  + +V     L +Q+   A  D LT +Y+        + + + S +  + 
Sbjct: 506 LRMIEVIAIQAAQAVLRA-QLYEQMERMATTDGLTGLYNHRTFQAKADEVLAQSRRYQRK 564

Query: 175 LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVN 234
            +++L D+D+FKS+ND YGH  GD+VL   AR I+ +  D  +VAR GGEEF + +P  +
Sbjct: 565 FSLILTDVDHFKSVNDTYGHPTGDQVLKGVARIIKTMARDTDIVARYGGEEFVIIMPETD 624

Query: 235 PVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCL 294
                 ++E+IR+ V+ + F  +   L +T+S+G+ +   S +       +L+  AD CL
Sbjct: 625 AKGAFTISERIREAVKAEVFQTEMGPLRITMSLGIATFPDSAMEK----QQLIDLADQCL 680

Query: 295 YRSKKDGRNRTSTM 308
           Y SK++GRN++ T+
Sbjct: 681 YHSKRNGRNQSVTV 694


>UniRef50_C4XKN6 Putative signaling protein n=2 Tax=Desulfovibrio magneticus RS-1
           RepID=C4XKN6_DESMR
          Length = 629

 Score =  226 bits (578), Expect = 6e-58,   Method: Composition-based stats.
 Identities = 55/188 (29%), Positives = 92/188 (48%), Gaps = 6/188 (3%)

Query: 121 MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEA---LKSPSLKQTQHLTV 177
           ++      +  +     + +++   A  D LT + +R    E    L   + +   +L++
Sbjct: 428 ISTGIFAAARDITERKIMEERLKEMATTDSLTGLNNRQHFLEHSSILFEMAKRHKANLSI 487

Query: 178 MLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVD 237
            L DID+FK +ND +GHE GD VL   ++          ++ R+GGEEFAV +P  +  +
Sbjct: 488 ALFDIDHFKQVNDTWGHEAGDLVLRELSKLALNCFRSSDIIGRIGGEEFAVIMPETDKEE 547

Query: 238 GLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRS 297
            +L +E+ RK VE   F ++   L +TVSIG+     +  T     N L   +D  LY +
Sbjct: 548 AILASERFRKIVESTRFEYENDLLSITVSIGIAQFNPNTNT---TINDLTKISDDALYTA 604

Query: 298 KKDGRNRT 305
           K +GRN  
Sbjct: 605 KANGRNMV 612


>UniRef50_Q3KAB6 Putative GGDEF domain regulatory protein n=2 Tax=Pseudomonas
           fluorescens RepID=Q3KAB6_PSEPF
          Length = 559

 Score =  226 bits (578), Expect = 6e-58,   Method: Composition-based stats.
 Identities = 68/191 (35%), Positives = 94/191 (49%), Gaps = 11/191 (5%)

Query: 128 VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSL---KQTQHLTVMLLDIDY 184
           V+   AA+     ++   A  D LT VY+R    E L   SL   +  +   ++L+D D+
Sbjct: 372 VAQRTAALTLANAELLNLATHDGLTGVYNRRRFDEKLTEYSLLFRRTGRPFALLLIDADH 431

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDG-LLMAE 243
           FK IND +GH  GD VL   A+ IQ  +     VAR GGEEFAV +P +   D   ++AE
Sbjct: 432 FKRINDTHGHAAGDDVLRQLAQLIQISIRSTDFVARYGGEEFAVLLPEIAKPDTPDIVAE 491

Query: 244 KIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           KIR  +    F        +TVSIGV     +  T T     L+  AD  LY++K  GRN
Sbjct: 492 KIRSAIAEADFPAVG---PVTVSIGVSLADPADNTPT----TLVKRADQQLYKAKAAGRN 544

Query: 304 RTSTMRYGEEV 314
           + +      EV
Sbjct: 545 QVACQASLFEV 555


>UniRef50_A1TWP6 Diguanylate cyclase n=2 Tax=Marinobacter RepID=A1TWP6_MARAV
          Length = 565

 Score =  226 bits (578), Expect = 6e-58,   Method: Composition-based stats.
 Identities = 60/189 (31%), Positives = 93/189 (49%), Gaps = 9/189 (4%)

Query: 128 VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDY 184
           V      +    +Q+   +  D LT V +R    E L++    +L+    L+++LLDID+
Sbjct: 372 VRERTEELEQANEQLRAISLTDGLTHVANRRRFDEKLETEWNRALRHEHELSLILLDIDH 431

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIV-GDKGLVARMGGEEFAVAVPSVNPVDGLLMAE 243
           FK +ND +GH  GD  L   A  +   V     LVAR GGEEFA+ +P+ +      +AE
Sbjct: 432 FKQVNDRFGHLVGDDCLVALASILSDEVQRSGDLVARYGGEEFAILLPTTDVAGAQQVAE 491

Query: 244 KIRKGVELQPFTWQQK--TLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
           ++R  V   P    +    + LT+S+GV +   +  +   D  +L+  AD  LY +K DG
Sbjct: 492 RMRLSVARTPVNSGEHMSPVSLTISLGVATLTPNRQS---DCQELIRRADEALYAAKSDG 548

Query: 302 RNRTSTMRY 310
           RNR      
Sbjct: 549 RNRVVVWHP 557


>UniRef50_D0LHJ8 Diguanylate cyclase n=1 Tax=Haliangium ochraceum DSM 14365
           RepID=D0LHJ8_HALO1
          Length = 303

 Score =  226 bits (578), Expect = 6e-58,   Method: Composition-based stats.
 Identities = 63/223 (28%), Positives = 108/223 (48%), Gaps = 9/223 (4%)

Query: 86  GAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALR 145
           G   +  + ++        P     +  +       AI   ++   + A  S  +++   
Sbjct: 76  GRWLVEDLGSTNGSYVNDMPVQRSPLQDSNFLKIGAAIFKFLLGAGIEA--SYYEEIYRM 133

Query: 146 ADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLS 202
              D LT V+++    E L+       +  + LT+++ DID+FK IND +GH  GD VL 
Sbjct: 134 TIIDGLTGVHNKRYFVEFLEREIARCARHQRPLTLLMFDIDHFKQINDTHGHLTGDYVLK 193

Query: 203 VFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY 262
             +R +++ +  + L+AR GGEEFA  +P  + V G+   E+IR+ V  +PF ++     
Sbjct: 194 EMSRRLRERIRKEELLARYGGEEFAAVLPETDHVGGMTFGEQIRQLVGGEPFEYEGDRFQ 253

Query: 263 LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
           +T+S+GV +     L    D    +  AD  LYR+K+ GRNR 
Sbjct: 254 VTISVGVHTLYGQSL----DVKGFIKHADDNLYRAKRSGRNRV 292


>UniRef50_Q1J2W1 Diguanylate cyclase, GAF, HAMP domains protein n=1 Tax=Deinococcus
           geothermalis DSM 11300 RepID=Q1J2W1_DEIGD
          Length = 555

 Score =  226 bits (578), Expect = 7e-58,   Method: Composition-based stats.
 Identities = 58/174 (33%), Positives = 86/174 (49%), Gaps = 8/174 (4%)

Query: 137 SLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYG 193
            L   +  ++  D LT +Y+R  L E          ++ Q L+++++D+D+FK  ND YG
Sbjct: 374 RLRATLRQQSIRDPLTGLYNRRYLEETFTRELARVQRRRQPLSLLMIDVDHFKQHNDTYG 433

Query: 194 HECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP 253
           H  GD +L   A H+Q+    + +V R GGEEF V +P  +       AE +R+ VE   
Sbjct: 434 HALGDTLLRRLATHLQRFFRTEDIVCRYGGEEFVVLLPECDAPQAQARAEALRRSVENLA 493

Query: 254 FTWQQKT-LYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
            T      + LT+SIG     AS+         L+  AD  LYR+K  GRNR  
Sbjct: 494 VTSNDAEFVALTISIG----GASWPDHATTPEDLLARADAALYRAKHRGRNRVE 543


>UniRef50_B9TNG7 Putative uncharacterized protein n=1 Tax=Ricinus communis
           RepID=B9TNG7_RICCO
          Length = 204

 Score =  226 bits (578), Expect = 7e-58,   Method: Composition-based stats.
 Identities = 58/186 (31%), Positives = 95/186 (51%), Gaps = 5/186 (2%)

Query: 128 VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVMLLDIDY 184
           + F +       +++   A  D LT++++R       E   + + +    L  ++LDID+
Sbjct: 9   LGFVLMIKERSDREIRTLAMTDPLTKIFNRRAFMIQAEKELAAAERSGLPLAFLMLDIDH 68

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEK 244
           FK IND YGH  GD+VL      +   +  +  + R GGEEF   +P  +    + +AEK
Sbjct: 69  FKQINDKYGHAAGDEVLVRIVEVLSSHLRKQDTLGRYGGEEFCALLPGTDAQGAMALAEK 128

Query: 245 IRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           +R  V +     ++ +L LT+SIG  +    +L  T D+ +LM EAD  LY++K  GRNR
Sbjct: 129 LRLEVAMTRIEVEENSLGLTLSIGGSTW--EHLGPTKDYRELMEEADRALYQAKTGGRNR 186

Query: 305 TSTMRY 310
           +   R 
Sbjct: 187 SLLYRT 192


>UniRef50_Q089K4 Diguanylate cyclase n=1 Tax=Shewanella frigidimarina NCIMB 400
           RepID=Q089K4_SHEFN
          Length = 312

 Score =  226 bits (577), Expect = 7e-58,   Method: Composition-based stats.
 Identities = 54/178 (30%), Positives = 94/178 (52%), Gaps = 9/178 (5%)

Query: 133 AAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQ---TQHLTVMLLDIDYFKSIN 189
            ++    +Q+    + D LT +++R    +  K    +     Q L+++++DIDYFK IN
Sbjct: 133 TSLEQAHQQIESLVNTDQLTGMHNRRSYNQLAKQECARAIRFNQQLSLLVIDIDYFKVIN 192

Query: 190 DNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGV 249
           DN+GH+ GD +L  FA+    ++     ++R+GGEEF + +P  +    +++AE+IR+ +
Sbjct: 193 DNFGHDGGDSILKQFAQICSDLLRQSDSLSRIGGEEFTIILPMTDGEGAMIIAERIREHI 252

Query: 250 ELQPFTW--QQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
               F        + +TVSIGV S  A    + D    L   AD  +Y +K+ GRN+ 
Sbjct: 253 AKHSFHTTQTNNNINVTVSIGVSSLTAGDKVIQD----LFSRADMAMYCAKRGGRNQV 306


>UniRef50_C4KD29 Response regulator receiver modulated diguanylate cyclase n=2
           Tax=Betaproteobacteria RepID=C4KD29_THASP
          Length = 634

 Score =  226 bits (577), Expect = 7e-58,   Method: Composition-based stats.
 Identities = 62/177 (35%), Positives = 94/177 (53%), Gaps = 7/177 (3%)

Query: 139 MKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKSINDNYGHE 195
            +++A  A  D LT + +R     AL    + S +  Q L+VM+LDID+FK IND++GH 
Sbjct: 457 NRRLAHAAMTDLLTNLPNRRSGMNALAKAWAASSRFEQPLSVMMLDIDHFKRINDSHGHA 516

Query: 196 CGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFT 255
            GD VL   A+ IQ+       + RMGGEEF V  P+ +    +  AE++R+ VE     
Sbjct: 517 VGDTVLRDVAQAIQQSARKDDSMCRMGGEEFLVICPNTDLKAAVQAAERLRRMVERLRIQ 576

Query: 256 WQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGE 312
             +  +  +VSIGV +            + L+  AD  LYR+K+ GRNR+  +  G+
Sbjct: 577 AGETEIQTSVSIGVATREVGMTET----DALVNAADRALYRAKQAGRNRSCVVVQGQ 629


>UniRef50_A1U7E6 Diguanylate cyclase n=1 Tax=Marinobacter aquaeolei VT8
           RepID=A1U7E6_MARAV
          Length = 405

 Score =  226 bits (577), Expect = 7e-58,   Method: Composition-based stats.
 Identities = 79/317 (24%), Positives = 126/317 (39%), Gaps = 25/317 (7%)

Query: 5   WFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLP 64
           W S      +  +  + T  IP V  R +A  ++ A        A+ +IG  G       
Sbjct: 98  WLSTTLVLVLAALMYVYTFHIPDVNLRIQAFSIVFA--------AACLIGATG------- 142

Query: 65  ALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAIC 124
            L             L+          +         V     +   + + L I      
Sbjct: 143 FLRHRESHNRMAGKMLIAMFLLVSAFFIFRFFRSFYEVPPEDFMNAGWLSALAIVAGEFL 202

Query: 125 PIMVSFSV--AAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVML 179
            I+ SF     A + L  +++  A  D LT +Y+R    E      S + +      +++
Sbjct: 203 VILSSFCTIWMASDELQDELSEIARIDPLTGLYNRRAFDECCDIEFSRAQRSGAPFAIIM 262

Query: 180 LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGL 239
            D+D+FK +ND YGH  GD+VL  FA  +++ +    +VAR GGEEF + +P  +   GL
Sbjct: 263 CDLDHFKRVNDRYGHHVGDEVLRRFANTLKEHIRKHDVVARFGGEEFVLLLPGKDTEQGL 322

Query: 240 LMAEKIRKGVELQPFTWQQKT-LYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSK 298
            +AEK+R        T      L L+ S GV    +S    +     ++  AD  LY +K
Sbjct: 323 EVAEKLRAKTADTQITIGDDVCLTLSASFGVAHYDSSDREWS----AVLHRADNALYAAK 378

Query: 299 KDGRNRTSTMRYGEEVV 315
           K GRNR   +    + V
Sbjct: 379 KQGRNRVVDLGTENQSV 395


>UniRef50_A7BV03 Sensor protein n=2 Tax=Beggiatoa sp. PS RepID=A7BV03_9GAMM
          Length = 866

 Score =  226 bits (577), Expect = 8e-58,   Method: Composition-based stats.
 Identities = 70/238 (29%), Positives = 110/238 (46%), Gaps = 29/238 (12%)

Query: 73  YTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSV 132
           Y      +LT +T +   +   +   D  V  PF I ++           +  I V    
Sbjct: 644 YELIYIIMLTALTDSKYKIEGLDKGADDYVTKPFDISEL-----------LARIRVGERT 692

Query: 133 AAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSIN 189
           A            A  D LT+VY+R+     L      + +  + L++++ DID FK+IN
Sbjct: 693 AIKKR-------EATIDGLTKVYNRNYFDMYLAQEVSRAKRYKRELSLIITDIDLFKNIN 745

Query: 190 DNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGV 249
           D YGH  GD VL  F + I +      LVAR GGEEF + +P      G ++AE++ + +
Sbjct: 746 DTYGHLTGDTVLQEFTQIIMQQCRRSDLVARFGGEEFIILLPETPLKGGTIVAERMCQRI 805

Query: 250 ELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
           +   F   Q+  ++T S GV S     L    D  +L+  AD+ LY++KK+GRN+   
Sbjct: 806 DAHIF---QEVEHITASFGVAS-----LITDRDGRELLRRADSALYQAKKNGRNQVVV 855


>UniRef50_A6Q525 Signal transduction response regulator n=1 Tax=Nitratiruptor sp.
           SB155-2 RepID=A6Q525_NITSB
          Length = 350

 Score =  226 bits (577), Expect = 8e-58,   Method: Composition-based stats.
 Identities = 58/181 (32%), Positives = 96/181 (53%), Gaps = 12/181 (6%)

Query: 132 VAAINSLMKQVA---LRADFDFLTQVYSRSGLYEALKSPSLK----QTQHLTVMLLDIDY 184
              IN L +++     +A+FD+LT++++R    E       +    + +  ++++LDID 
Sbjct: 172 YEEINHLRRELRDTKNKAEFDYLTELFNRRKFEEYFHKLLKEFNEGEGKPFSLIILDIDD 231

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEK 244
           FK IND YGH  GD+VL   +  I+  +    + AR+GGEEFA+ +P     +   +AE+
Sbjct: 232 FKQINDTYGHLLGDEVLKNLSSLIKTFLHSAHIPARIGGEEFAILLPETPLDEAKTIAER 291

Query: 245 IRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           +RK VE +     +  L  TVSIGV   +       D  + L+  AD  LY +K++G+N 
Sbjct: 292 LRKTVENRTIPIAEGDLNFTVSIGVAQVQ-----KGDTMDSLLKRADEALYEAKRNGKNM 346

Query: 305 T 305
            
Sbjct: 347 V 347


>UniRef50_B9ZRW3 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Thioalkalivibrio
           sp. K90mix RepID=B9ZRW3_9GAMM
          Length = 791

 Score =  226 bits (577), Expect = 8e-58,   Method: Composition-based stats.
 Identities = 53/183 (28%), Positives = 87/183 (47%), Gaps = 11/183 (6%)

Query: 126 IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDI 182
           I +   +     L   +  +A +D LT   +R      L   + +  +     +++LLDI
Sbjct: 612 IAMFHDITRQKELEAALEHQAFYDPLTDAANRGYFETLLDQEARRAQRYAHPCSLLLLDI 671

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           D+FK IND +GHE GD+VL      ++  + +  ++ R GGEEF V +P  +   G  +A
Sbjct: 672 DHFKRINDTFGHEVGDEVLRFLVHALKGRLREADVLGRWGGEEFVVLLPGTDAERGQHVA 731

Query: 243 EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           E++R+ V    F        +T+S+GV   R       +     +  AD  +Y +KK GR
Sbjct: 732 EQLREQVTATAFPCVG---LVTISLGVAECRP-----GESIRDWVKRADEAMYVAKKGGR 783

Query: 303 NRT 305
           NR 
Sbjct: 784 NRV 786


>UniRef50_Q1K485 Diguanylate cyclase n=1 Tax=Desulfuromonas acetoxidans DSM 684
           RepID=Q1K485_DESAC
          Length = 370

 Score =  226 bits (577), Expect = 9e-58,   Method: Composition-based stats.
 Identities = 55/184 (29%), Positives = 99/184 (53%), Gaps = 5/184 (2%)

Query: 128 VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEAL---KSPSLKQTQHLTVMLLDIDY 184
           ++ ++  I     ++A  A  D LT  ++R    E        + +  Q L++++ DID+
Sbjct: 184 LNEALDTIKKRNAEIAELAVRDSLTGSFNRGYFNETFPGAIRRAQRYQQSLSLIMCDIDH 243

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIVGDK-GLVARMGGEEFAVAVPSVNPVDGLLMAE 243
           FK IND+YGH+ GD+V+   A+ + + +      +AR GGEEF + +P  N    L++AE
Sbjct: 244 FKLINDHYGHQTGDRVIKSVAQGLAQSLRQGVDWLARYGGEEFVIVLPETNLEGALVVAE 303

Query: 244 KIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           ++R+ +  Q      +++ LT S GV      + ++    N ++  AD CLY++KK+GRN
Sbjct: 304 RMRRSIADQEIACDPQSIRLTASFGVAGCDPEHASML-TGNGMIAAADRCLYQAKKEGRN 362

Query: 304 RTST 307
              +
Sbjct: 363 CCCS 366


>UniRef50_Q2LS38 Response regulator protein with GGDEF domain n=2 Tax=Syntrophus
           aciditrophicus SB RepID=Q2LS38_SYNAS
          Length = 356

 Score =  226 bits (577), Expect = 9e-58,   Method: Composition-based stats.
 Identities = 68/242 (28%), Positives = 113/242 (46%), Gaps = 13/242 (5%)

Query: 73  YTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLG------IATMAICPI 126
               +T  L        + L       I +GS  SI ++ S +         A   +   
Sbjct: 113 LLVIITSALALGKLTTLLELALIGTCFIFLGSHSSINELLSLKYAGGMFAQFAPFVLVAY 172

Query: 127 MVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVMLLDID 183
           + +   + I   + +V + ++ D LT +Y+R G       L   S + ++ L+++L+D D
Sbjct: 173 IATMFASDIRYGLNKVKMMSETDELTGIYNRRGFAIVAGRLLGQSARYSRPLSLLLIDSD 232

Query: 184 YFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAE 243
             K IND YGH  GD++L      IQ  +    ++AR GG+EF + +P   P   L +AE
Sbjct: 233 NLKKINDEYGHHAGDQLLITLVNTIQAQLRHTDILARHGGDEFIILLPETPPSGALDVAE 292

Query: 244 KIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           +IR  +E  P   + K ++ T SIGV     SY +   + + L+ +AD  +Y +K  GRN
Sbjct: 293 RIRNAIETTPIVLEGKIVHTTASIGVA----SYPSEGYNIDVLLAQADHKMYAAKLGGRN 348

Query: 304 RT 305
           R 
Sbjct: 349 RV 350


>UniRef50_Q1K453 Diguanylate cyclase n=1 Tax=Desulfuromonas acetoxidans DSM 684
           RepID=Q1K453_DESAC
          Length = 481

 Score =  226 bits (577), Expect = 9e-58,   Method: Composition-based stats.
 Identities = 63/208 (30%), Positives = 98/208 (47%), Gaps = 9/208 (4%)

Query: 105 PFSIPQMFSARLGIAT-MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY-- 161
           P       +  + +A    +  I++  +   IN   K++   A  D LT++ +R  +   
Sbjct: 276 PMLRQIRLTLLINVAICFTVTFIVIILTQMTINRYQKRLEEMALTDKLTRIANRQAIDLH 335

Query: 162 -EALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVAR 220
            + L     +     +V+L D+D FK IND +GH  GD VL   A  +   + D  +V R
Sbjct: 336 LQQLFKEQQRHQVPFSVILFDLDNFKQINDTHGHIAGDAVLQNIANIVTTELRDCDVVGR 395

Query: 221 MGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLT 280
            GGEEF V +      D L  AE IR  ++     ++++TLY T S GV   R       
Sbjct: 396 WGGEEFLVLLKHCQLDDALKRAESIRLAIQSYAIGFEEQTLYTTASFGVVEYR-----DQ 450

Query: 281 DDFNKLMVEADTCLYRSKKDGRNRTSTM 308
           DD N L+  AD  LY +K++G+NR   +
Sbjct: 451 DDHNTLLKRADQALYIAKQNGKNRCEVI 478


>UniRef50_B7R5U6 PAS fold family protein n=13 Tax=Thermoanaerobacterales
           RepID=B7R5U6_9THEO
          Length = 692

 Score =  226 bits (577), Expect = 9e-58,   Method: Composition-based stats.
 Identities = 47/187 (25%), Positives = 87/187 (46%), Gaps = 11/187 (5%)

Query: 125 PIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLD 181
            I +   ++      + +  ++  D LT +Y+R    + L+    +  ++    ++++ D
Sbjct: 514 AIGIIRDISERKRFEELLYRQSITDPLTNIYNRRFFMQMLEQEIERVKRNKKLFSLIMFD 573

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           +D+FK++ND +GH  GD VL   A  ++  +      AR GGEEF + +P  +  +   +
Sbjct: 574 LDHFKNVNDRFGHAAGDMVLKSVADTVKGRIRKTDYFARWGGEEFIILLPETSLNNAAEL 633

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
           AE++RK +         K   +T S GV   R      TD  + +++  D  LY +K  G
Sbjct: 634 AEELRKKISETELDGIGK---VTASFGVTEYR-----NTDTVDTVLLRVDGALYEAKGSG 685

Query: 302 RNRTSTM 308
           RN     
Sbjct: 686 RNCVKIA 692


>UniRef50_A1U2H0 Diguanylate cyclase n=2 Tax=Marinobacter RepID=A1U2H0_MARAV
          Length = 630

 Score =  226 bits (576), Expect = 9e-58,   Method: Composition-based stats.
 Identities = 78/328 (23%), Positives = 132/328 (40%), Gaps = 33/328 (10%)

Query: 10  FSTGVLIVPCMLT----LAIPGVLPRFKAEQMMPAIALIVSVI---------ASVVIGGA 56
            + G+L +  +L     L +P +L  F     M  ++++  +           + V    
Sbjct: 293 MTAGMLALAGLLIPYQWLILPSILVAFVGCSTMLMLSVVRWIKKDPAARYYTVAWVFMLF 352

Query: 57  GSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMF---- 112
           G +   L            +    +    G + + +     ++      F+  Q      
Sbjct: 353 GGIVLALSKFTMLPRNLLTENATQVGSALGVILLSIALADRLNREKKKSFAAQQKLLREE 412

Query: 113 ---------SARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEA 163
                    S R+     A+    V      +  L +Q+   +  D LT + +R    + 
Sbjct: 413 RKARLAQEKSLRIQQEANALLEERVQERTRDLEILNEQLLELSATDPLTGLKNRGHFDKK 472

Query: 164 LKS---PSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIV-GDKGLVA 219
            +S    + +  + L+++++DID+FK  ND YGH  GD  L + A  I++ V   + L A
Sbjct: 473 FQSDVVHAYRFEETLSLLIVDIDHFKGFNDTYGHLVGDDCLKMVADCIKQHVTRPQDLAA 532

Query: 220 RMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTL 279
           R GGEEF V +P         +AE IR+ ++   F    + L+LTVSIGV S      + 
Sbjct: 533 RYGGEEFVVLLPDTPEAGACRVAELIREDIQKMAFRVSDQVLHLTVSIGVCS---CAPSQ 589

Query: 280 TDDFNKLMVEADTCLYRSKKDGRNRTST 307
            D    L   AD  LYR+K +GRNR   
Sbjct: 590 ADATKALFACADGALYRAKAEGRNRVVA 617


>UniRef50_B4U5K2 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Hydrogenobaculum
           sp. Y04AAS1 RepID=B4U5K2_HYDS0
          Length = 901

 Score =  226 bits (576), Expect = 9e-58,   Method: Composition-based stats.
 Identities = 59/191 (30%), Positives = 99/191 (51%), Gaps = 14/191 (7%)

Query: 120 TMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLT 176
           T+ +C +      + I    ++++++   D LT + +R  L + L+     + +  + L+
Sbjct: 721 TLILCILQDITEESMIIKYFEELSIK---DDLTGICNRRCLEDKLEEYLTLAKRYNRPLS 777

Query: 177 VMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPV 236
           V++ DID+FK IND+YGH+ GDKVL   A  +   +    ++AR GGEEF +  P     
Sbjct: 778 VIMFDIDFFKHINDSYGHDIGDKVLKTIANIVLSNIRATDILARYGGEEFVIISPETTLE 837

Query: 237 DGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYR 296
           D   +AEK+RK +E   F   ++   +T S GV S     L   D    ++   D  LY+
Sbjct: 838 DAKALAEKLRKEIENFLF---EEGFSITCSFGVTS-----LNQEDTKETILKRVDEALYK 889

Query: 297 SKKDGRNRTST 307
           +K++GRNR   
Sbjct: 890 AKREGRNRVVA 900


>UniRef50_Q2BML0 Putative diguanylate cyclase (GGDEF domain) n=1 Tax=Neptuniibacter
           caesariensis RepID=Q2BML0_9GAMM
          Length = 577

 Score =  226 bits (576), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 76/307 (24%), Positives = 132/307 (42%), Gaps = 22/307 (7%)

Query: 16  IVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVI------------ASVVIG-GAGSLAFP 62
           ++   + L +P   PR      +    L+   I             +  IG    +L   
Sbjct: 269 MLFARVFLELPSRFPRLNLSFNLLGGVLLFCGILFLLLDDVLSLLYTAFIGIVPFALLMI 328

Query: 63  LPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMA 122
           +     C          L   V   +  V+ A +V  I          +    L  A + 
Sbjct: 329 IAGACACLNGVKEARYFLGAAVFAMISAVITAFTVSGIVEYKAIGFHAVEYGMLIEAVLF 388

Query: 123 ICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVML 179
              +   F +     +  Q    AD D LT +Y+R G  + ++     + +  + L +++
Sbjct: 389 ALALAYQFRINQEEKVAAQ--QLADRDQLTGLYNRRGFDKVMEPVFGNAYRHHRELCLLV 446

Query: 180 LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGL 239
           LDID+FK+IND +GH  GD VL+  A+ +Q  +    L+AR GGEEF + +P  N ++ +
Sbjct: 447 LDIDHFKAINDRHGHGYGDLVLTDLAKVLQHELRAGDLIARWGGEEFLLLLPETNHMEAV 506

Query: 240 LMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKK 299
            +AE++ + +  +         + TVSIG+   +   +     F +L+VEAD  LYR+K+
Sbjct: 507 TLAERLIRNISNREVEGDGVQEHYTVSIGIAELKPPIV----SFKQLLVEADKHLYRAKE 562

Query: 300 DGRNRTS 306
            GRN+  
Sbjct: 563 TGRNKAC 569


>UniRef50_B8KV43 Sensory box histidine kinase n=1 Tax=gamma proteobacterium NOR51-B
           RepID=B8KV43_9GAMM
          Length = 494

 Score =  226 bits (576), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 61/195 (31%), Positives = 100/195 (51%), Gaps = 7/195 (3%)

Query: 118 IATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQH 174
           I+      IM    ++   ++ +++   AD D LT   +R  L   +KS    + +  + 
Sbjct: 296 ISGQFAGSIMFLKDISDRKAVERRLKAIADKDPLTGAGNRRALESVIKSELSRAHRHDEP 355

Query: 175 LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVN 234
           L+V +LDID+FKS+NDNYGH  GD+VL   A+  + ++      AR+GGEEFA+ +P  +
Sbjct: 356 LSVAILDIDWFKSVNDNYGHLMGDRVLIDIAKLCKDLIRPYDTFARIGGEEFALLLPKTS 415

Query: 235 PVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCL 294
             +   +AE++R+ V        +  + +T+SIGV               +++  AD  L
Sbjct: 416 VPEAERLAERLRQRVAEHTTQAGENRVQVTISIGVALLAKG----AKTLEEMIESADRAL 471

Query: 295 YRSKKDGRNRTSTMR 309
           Y +K DGRNR  T  
Sbjct: 472 YCAKLDGRNRVVTFE 486


>UniRef50_B9Z0Y0 Diguanylate cyclase n=1 Tax=Lutiella nitroferrum 2002
           RepID=B9Z0Y0_9NEIS
          Length = 528

 Score =  226 bits (576), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 71/283 (25%), Positives = 122/283 (43%), Gaps = 19/283 (6%)

Query: 30  PRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVE 89
               AE    ++ L+++++A V+I   G L   L +          ++  L   VT  + 
Sbjct: 248 RTAAAESRRLSLQLVIAIVAGVLI--YGWLTLWLGSNTVRHALRASELAILPGAVTTMLA 305

Query: 90  IVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFD 149
                  V        F++   F    G           +  V  +     ++A  A  D
Sbjct: 306 TTWTFYWV--------FALIAAFVGFFGYRMFTYWLDSSTRLVNELAEANSKLAHLARTD 357

Query: 150 FLTQVYSRSGLYEALKSPSLKQTQHL---TVMLLDIDYFKSINDNYGHECGDKVLSVFAR 206
            LT + +R  L EAL+    +  ++    +++LLDID+FK +ND YGH+ GD V+    +
Sbjct: 358 TLTGLPNRRALEEALEQQLQRSRRNGEQASLVLLDIDHFKVVNDRYGHDAGDAVIRALGK 417

Query: 207 HIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVS 266
            + + + +  +  R GGEEF V + +V+       AE++R  VE       +  +  T+S
Sbjct: 418 AMSETIRNVDVAGRWGGEEFLVVLANVDEEGAAAFAERLRTRVESSTVAHGELHVRYTIS 477

Query: 267 IGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
           +GV      +          +  AD  LYR+K DGRNRT+  +
Sbjct: 478 LGVAPLSTPHR------EAWLKRADEALYRAKLDGRNRTAIAQ 514


>UniRef50_C1D6I3 Diguanylate cyclase n=1 Tax=Laribacter hongkongensis HLHK9
           RepID=C1D6I3_LARHH
          Length = 350

 Score =  225 bits (575), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 59/177 (33%), Positives = 94/177 (53%), Gaps = 6/177 (3%)

Query: 139 MKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHE 195
            +++      D LT +Y+R    + L+  + +  +H   L  ++LD D+FK IND +GH+
Sbjct: 173 RERLKWLGLTDPLTGLYNRRYFEQRLQEEAQRTRRHGDPLACLMLDADHFKRINDTWGHQ 232

Query: 196 CGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFT 255
            GD VL V AR +++ +    + AR+GGEEFAV +PS       L+AE+IR  +  +P  
Sbjct: 233 AGDVVLKVLARRVRQQLRGCDVAARIGGEEFAVLLPSTPVRHVQLVAERIRLAIAGEPVH 292

Query: 256 WQQK-TLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYG 311
                 L ++VS+G          +     +LM  AD  LY++K++GRNRT     G
Sbjct: 293 VSPDCVLQVSVSLGAAMLAPGAADI--SPERLMARADAALYQAKRNGRNRTMLAAAG 347


>UniRef50_C1TNC9 Diguanylate cyclase (GGDEF) domain-containing protein n=1
           Tax=Dethiosulfovibrio peptidovorans DSM 11002
           RepID=C1TNC9_9BACT
          Length = 494

 Score =  225 bits (575), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 63/236 (26%), Positives = 109/236 (46%), Gaps = 13/236 (5%)

Query: 76  QVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAI 135
             T ++  +    E     + ++D+            S       +    +++   +  I
Sbjct: 269 PYTRMVGALVDYSERKTDLDGLLDVMSEISSGASDEIS--YICEALKDMILVLKDKMENI 326

Query: 136 NSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNY 192
            S   ++   A+ D LT +++R  + + L S + + +++   L+V+++DID+FK++NDN+
Sbjct: 327 QSYSDRLEYLANRDSLTGLWNRRKMDQILLSETERSSRYGSSLSVVMVDIDHFKNVNDNF 386

Query: 193 GHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQ 252
           GHE GD VLS  A  ++        V R GGEEF V +P  +    L  AE++R  VE  
Sbjct: 387 GHEVGDTVLSSIAALMKNCTRAGDSVGRWGGEEFLVVLPETDVKGALEYAERMRSAVEDN 446

Query: 253 PFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
            F      + +T S GV   R+         N+ +  AD  LY +K+ GRNR    
Sbjct: 447 VFHDD---IRITSSFGVTQYRSGEP-----VNEFVARADEALYDAKEKGRNRVEIC 494


>UniRef50_Q0A8G7 Diguanylate cyclase n=1 Tax=Alkalilimnicola ehrlichii MLHE-1
           RepID=Q0A8G7_ALHEH
          Length = 237

 Score =  225 bits (575), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 50/183 (27%), Positives = 83/183 (45%), Gaps = 11/183 (6%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQ---TQHLTVMLLDIDYFKS 187
            +       +++   A  D LT + +R      L     +     + + V++ D+D+FK 
Sbjct: 57  DITERKRDQERIRYLATTDALTGIMNRGEFTRHLTKEIERAARFNRPVAVVMYDLDHFKR 116

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           +ND YGH+ GD+VL      +   +    + AR GGEEF + +P  +    +  AE++R 
Sbjct: 117 VNDTYGHDAGDEVLKTAVAQVNNAIRRVDVHARWGGEEFILLLPETDLAAAVKSAERLRA 176

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
            +   PF    +   +T S GV +     L   D F+ L+  AD  LY +K  GRNR   
Sbjct: 177 AIAEHPFK---QPERVTASFGVTT-----LGPRDRFDVLIKRADDALYLAKHAGRNRVEA 228

Query: 308 MRY 310
           +  
Sbjct: 229 LSP 231


>UniRef50_Q2IXE2 Response regulator receiver modulated diguanylate cyclase n=6
           Tax=Alphaproteobacteria RepID=Q2IXE2_RHOP2
          Length = 457

 Score =  225 bits (575), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 59/170 (34%), Positives = 95/170 (55%), Gaps = 9/170 (5%)

Query: 144 LRADFDFLTQVYSRSGLYEALKSPSLK---QTQHLTVMLLDIDYFKSINDNYGHECGDKV 200
             A  D LT +++R  +   L + + +   + + L +M+LDID+FK+IND YGH+ GD V
Sbjct: 290 EMAITDGLTGLHNRRYMESHLATLAEQAGSRGKPLALMILDIDFFKAINDTYGHDAGDDV 349

Query: 201 LSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQ-- 258
           L  FA  I+K +    L  R GGEEF + +P  +     ++AE++R+ +  +PF  ++  
Sbjct: 350 LREFAVRIKKSIRGIDLACRYGGEEFVIVMPETDLQVAQMVAERLRRAIAGEPFAIEKGT 409

Query: 259 KTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
           K + +T+SIG+ +         +    L+  ADT LYR+K DGRNR    
Sbjct: 410 KRIAVTISIGLSTLE----RKGEAVRDLLKRADTALYRAKHDGRNRVVAA 455


>UniRef50_B7WUF6 Diguanylate cyclase n=1 Tax=Comamonas testosteroni KF-1
           RepID=B7WUF6_COMTE
          Length = 373

 Score =  225 bits (575), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 62/209 (29%), Positives = 106/209 (50%), Gaps = 20/209 (9%)

Query: 116 LGIATMAICPIMV------SFSVAAINSLMKQVALR-------ADFDFLTQVYSRSGLYE 162
           L + ++A C  +V      S ++ ++  L +++ ++       A  D LT V +R    E
Sbjct: 158 LALTSLAFCAFVVRATRELSRALQSLLRLRRELEIQHSIASNAARTDDLTGVNNRRAFNE 217

Query: 163 ALK---SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVA 219
             +   + + +    L  +L DID+FK IND +GH  GDKVL    R I+  + +  L  
Sbjct: 218 KAETMFAYTRRYGVPLCALLFDIDHFKQINDTHGHAAGDKVLQAVVRQIKSALREADLCG 277

Query: 220 RMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTL 279
           R+GGEEF V +   N  + + +AE+IR  V+         TL +T+S+GV    ++    
Sbjct: 278 RLGGEEFGVLLAGTNMQEAVQIAERIRLAVQAIKEPVNDTTLQVTISVGVAEADSACA-- 335

Query: 280 TDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
             D + L+ +AD  +YR+K +GRN+  + 
Sbjct: 336 --DVSTLLKQADAAMYRAKSNGRNQVHSC 362


>UniRef50_Q21KC2 GGDEF domain n=1 Tax=Saccharophagus degradans 2-40
           RepID=Q21KC2_SACD2
          Length = 234

 Score =  225 bits (575), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 54/185 (29%), Positives = 91/185 (49%), Gaps = 6/185 (3%)

Query: 132 VAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSI 188
           +  + S + ++  + + D LT +Y+R    E++      + +  Q  ++ L+D+D+FK +
Sbjct: 35  IQQLESRIAELTEQVNTDSLTGLYNRKHFNESIAQELERTQRSRQPTSLALIDLDHFKVV 94

Query: 189 NDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKG 248
           ND +GH  GD+VL   A+ I   +    +  R GGEE AV  PS   +    +AE++R+ 
Sbjct: 95  NDTHGHIAGDEVLKAVAKAIGNTIRKLDIACRYGGEEIAVIFPSTYQLVASQVAERLRQA 154

Query: 249 VELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
           +E         T+ +T SIGV +  A        F   +   D  LY +K  GRNR +T 
Sbjct: 155 IENCTVNHGGSTIPITASIGVDTYTAQSKETAVQF---IERVDQLLYDAKHLGRNRVATR 211

Query: 309 RYGEE 313
            +  E
Sbjct: 212 TFSSE 216


>UniRef50_B4RZE8 GGDEF domain protein n=2 Tax=Alteromonadales RepID=B4RZE8_ALTMD
          Length = 325

 Score =  225 bits (575), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 51/181 (28%), Positives = 93/181 (51%), Gaps = 7/181 (3%)

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDN 191
           +  L +++   +  D LT +++R    E         +++ +  T ++LDID+FK IND 
Sbjct: 148 MEHLNQELKTASRVDGLTGLFNRRYWQERFDEMYKLCVRRDKPSTAVMLDIDHFKRINDT 207

Query: 192 YGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVEL 251
           YGH+ GDKV+ + A  I++ V +  L  R GGEEFA+ +      D  ++AE+IR+  + 
Sbjct: 208 YGHQAGDKVIKMLAALIKRCVRETDLAGRYGGEEFAIILNDSTVEDARIVAERIRQLAQR 267

Query: 252 QPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYG 311
                + +++  TVS+G+    +++          +  AD  LY +K+ GRN+       
Sbjct: 268 LVVEHEGESINFTVSLGLAQFCSAFKGPL----AWLECADKALYDAKESGRNQYRVYDTS 323

Query: 312 E 312
           +
Sbjct: 324 Q 324


>UniRef50_B0C0K6 Diguanylate cyclase (GGDEF) domain protein n=3 Tax=Acaryochloris
           marina MBIC11017 RepID=B0C0K6_ACAM1
          Length = 449

 Score =  225 bits (575), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 55/188 (29%), Positives = 92/188 (48%), Gaps = 8/188 (4%)

Query: 129 SFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYF 185
           +     +    + +   A  D LT+VY+R      L     +  +    ++++++DID+F
Sbjct: 249 NLMANQLEQSQQDLYRLATLDGLTEVYNRREFNRWLLVEIERSQRGEHPVSLIMVDIDHF 308

Query: 186 KSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKI 245
           K +ND YGH+ GD  L   A+ +Q+ V    +V R GGEEF V +P     D  ++AE+I
Sbjct: 309 KRLNDTYGHQAGDLALCEVAQLLQREVRPGDIVCRYGGEEFGVILPKATSADSWVIAERI 368

Query: 246 RKGVELQPFTWQQKT-LYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           R  +  +      +  + +T S+GV +    Y    D   +L+ +AD  LY +K  GRNR
Sbjct: 369 RLAIAEKSVVLPSQQHIDMTASLGVAT----YPDHADCKERLVKQADQALYTAKYQGRNR 424

Query: 305 TSTMRYGE 312
             +    E
Sbjct: 425 VHSAEVNE 432


>UniRef50_B6ESF0 Membrane associated GGDEF protein n=1 Tax=Aliivibrio salmonicida
           LFI1238 RepID=B6ESF0_ALISL
          Length = 712

 Score =  225 bits (575), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 61/222 (27%), Positives = 112/222 (50%), Gaps = 14/222 (6%)

Query: 89  EIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADF 148
           E   + N+ + +   SPF + ++F   LG+    I  ++  +    +     ++   + +
Sbjct: 501 ETNTLINNWLSVKYTSPFDV-KLFKVLLGVIVAIIGALL--YRQKLLKKYNTKLIQLSTY 557

Query: 149 DFLTQVYSRSGLYEAL---KSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LT +Y+R  +   L   +  SL+    L+V++ DIDYFK IND +GH  GD+V+   +
Sbjct: 558 DSLTSLYNRRVIDTHLVKQQKLSLRTDMPLSVIMCDIDYFKKINDTFGHIAGDEVIVNMS 617

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
             +   +    +V R GGEEF +  P+ +     ++AE +RK +E  P T +Q    +T+
Sbjct: 618 ALLLNNIRTSDIVGRWGGEEFIIICPNTHSSGAKVLAECLRKKIEKMPATNEQ---TITM 674

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
           S G+     +       + +L+++AD  LY +K+ GRN+   
Sbjct: 675 SFGIAQFNENL-----SYEELLIKADAALYAAKEQGRNKVVI 711


>UniRef50_Q1DC46 FHA domain/GGDEF domain protein n=2 Tax=Myxococcales
           RepID=Q1DC46_MYXXD
          Length = 354

 Score =  225 bits (574), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 63/160 (39%), Positives = 90/160 (56%), Gaps = 7/160 (4%)

Query: 149 DFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LT + ++    E L+     S +  + LT+M+ DID+FK IND +GH  GD VL   A
Sbjct: 197 DGLTGINNKRYFLEYLEKEMGRSTRYQRTLTLMMFDIDHFKQINDVHGHLAGDYVLRELA 256

Query: 206 RHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTV 265
           + I+++V  +   AR GGEEFAV +P   P    L AEKIR+ +E + F +  K + +T+
Sbjct: 257 QSIKRLVRREQCFARYGGEEFAVVLPEDGPDKARLFAEKIRRLIEGKSFVYDDKEIPVTI 316

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
           SIGV    +  L  T      +  AD  LY++KK GRNR 
Sbjct: 317 SIGVAEQTSDMLEPT----HFIKVADANLYKAKKSGRNRV 352


>UniRef50_A8UY33 Putative uncharacterized protein n=1 Tax=Hydrogenivirga sp.
           128-5-R1-1 RepID=A8UY33_9AQUI
          Length = 345

 Score =  225 bits (574), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 52/178 (29%), Positives = 86/178 (48%), Gaps = 7/178 (3%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKS 187
            +  +   +++V   A+ D LT + +R     AL        K     +V+++D+D FK 
Sbjct: 170 EIERLREELRRVKEEANIDPLTGLRNRRSFERALSEFFRDFKKFGYPFSVIMIDLDNFKQ 229

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           IND YGH  GDKVL      ++  +  K + AR GGEEF + +P +   + L++AE++RK
Sbjct: 230 INDTYGHLAGDKVLKEIGNILRNYLRAKDVPARTGGEEFTIILPGITREEALMVAERLRK 289

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
            +       + K +  T S GV           +    L+  AD  LY++K+ G+N  
Sbjct: 290 VIANYTVEHEDKKINPTASFGVAEVN----EQVETPEDLLRLADENLYKAKRRGKNTV 343


>UniRef50_UPI0000E11028 response regulator receiver modulated diguanylate cyclase n=1
           Tax=Glaciecola sp. HTCC2999 RepID=UPI0000E11028
          Length = 323

 Score =  225 bits (574), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 66/236 (27%), Positives = 113/236 (47%), Gaps = 14/236 (5%)

Query: 78  TCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINS 137
             LLT    +  IV   ++  D  + SPF+  ++  A+L IAT  +  +  S S      
Sbjct: 88  IVLLTDGVESKLIVDGLHAGADDFLASPFN-KELVEAKL-IATNRLFGLRKSHS-----E 140

Query: 138 LMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGH 194
              Q+   +  D LT + +R    + LK     + +  + + +   D+D+FK+IND  GH
Sbjct: 141 QYNQLQKESLTDVLTGISNRRHFKDILKKEMVKAQRHDRAMCIAYFDLDHFKAINDGLGH 200

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
           + GD+VL   +  I + +  +    R+GGEEF + +P  +  + L+ +E+ R  +E    
Sbjct: 201 DAGDEVLRKVSSAISETLRAEDSFGRLGGEEFCICMPDTSLNEALIPSERYRLMIEKLTI 260

Query: 255 TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRY 310
            +  K + +T S GV   +        D N L+  AD  LY+SK  GRN+ + + Y
Sbjct: 261 EYNNKPINVTASFGVTEFKP----FLHDINSLLAHADEALYKSKHQGRNQVTLLPY 312


>UniRef50_Q31GI5 Diguanylate cyclase (GGDEF domain) n=1 Tax=Thiomicrospira crunogena
           XCL-2 RepID=Q31GI5_THICR
          Length = 532

 Score =  225 bits (574), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 66/205 (32%), Positives = 98/205 (47%), Gaps = 14/205 (6%)

Query: 108 IPQMFSARLGI--ATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK 165
           I + F   L I    + I  ++V F +       + +   A  D LT + +RS    AL 
Sbjct: 332 ITENFLQHLLINEFLLLIISLLVFFFIRNQIRQRRLLHKMAKTDNLTGLPNRSIFKRALN 391

Query: 166 SPSLKQTQ---HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMG 222
               +  +    L+++  DID+FK IND YGH  GDKVL   AR+I+  +  K + AR G
Sbjct: 392 ENIKRSNKKQWPLSLIFFDIDHFKKINDTYGHLVGDKVLKKVARNIEDGLTHKDIFARWG 451

Query: 223 GEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDD 282
           GEEF + +P+ +  D   +AE++R+ +E          + +T S GV   R       D 
Sbjct: 452 GEEFVILLPNTDLQDAEKVAERLRQKLEAMT----DFDITITSSFGVSDLRPD-----DT 502

Query: 283 FNKLMVEADTCLYRSKKDGRNRTST 307
               M   D  LYRSK+ GRNR + 
Sbjct: 503 AESFMQRGDEMLYRSKEQGRNRVTA 527


>UniRef50_B0TJ24 Periplasmic/7TM domain sensor diguanylate cyclase n=4
           Tax=Shewanella RepID=B0TJ24_SHEHH
          Length = 623

 Score =  225 bits (574), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 78/322 (24%), Positives = 141/322 (43%), Gaps = 28/322 (8%)

Query: 10  FSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIG--------------G 55
             + ++++   L  A  G             + L   +  ++ +G              G
Sbjct: 312 MLSCIMLMYMSLAQAFKGNKLAKLFAIGWAGMMLGALLSGAIYLGLLHWDLQAKTPFILG 371

Query: 56  AGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSAR 115
                  + AL+  A+RY  +    L     A+     A    + ++       +  +  
Sbjct: 372 LSIEVIFMAALL--AIRYNDERLAKLQIQQDALLQAKKAEETKEEALHIEARSSEKLAKM 429

Query: 116 LGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQT 172
           +   T+ +       ++  +N   +++  +   D LT V +R+     + +    S +Q 
Sbjct: 430 VQERTLEL-----EIALRELNEANQKLTEQTRIDSLTGVKNRASFDRRILAEGRISRRQQ 484

Query: 173 QHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIV-GDKGLVARMGGEEFAVAVP 231
             L++++LDID FK IND+YGH  GD+ L V A  +++I+     LV+R GGEEFA+ +P
Sbjct: 485 APLSILMLDIDRFKLINDSYGHLAGDQALRVIADQLKQILKRPTDLVSRFGGEEFAIILP 544

Query: 232 SVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEAD 291
           + + +    +AE IRK +   P  W    + LTVSIGV S     +T  +    L+ +AD
Sbjct: 545 NTDKIGAQQVAETIRKVISKLPICWGGNRIRLTVSIGVSS---EIITSEEHTTLLLEQAD 601

Query: 292 TCLYRSKKDGRNRTSTMRYGEE 313
             LY++K DGRN+       ++
Sbjct: 602 KALYQAKNDGRNQVKLYSPDQD 623


>UniRef50_B9QV28 GGDEF domain protein n=1 Tax=Labrenzia alexandrii DFL-11
           RepID=B9QV28_9RHOB
          Length = 273

 Score =  225 bits (574), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 63/186 (33%), Positives = 95/186 (51%), Gaps = 7/186 (3%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKS 187
            V A   L +Q  ++A  D LTQV++R    E        +++    L+V LLDID+FKS
Sbjct: 77  EVKARAELAEQFRMQAITDGLTQVFNRGHFLELCNHELKARSRTEAPLSVALLDIDHFKS 136

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           +ND YGH  GD+ L V AR ++  +    +V R GGEEF++ +P  N  +   +A+++RK
Sbjct: 137 VNDTYGHAAGDEALRVVARTLENSLRQSDVVCRWGGEEFSLLMPRTNSENASGLADRLRK 196

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSG----RASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
            +          +  LT S GV +      A   T  D  + L  +AD  LY++K  GRN
Sbjct: 197 TLSEIVIKEGGTSFSLTASFGVATMAGPNPACKATGADAIDLLFKDADDALYKAKDAGRN 256

Query: 304 RTSTMR 309
           +  T  
Sbjct: 257 KVITAE 262


>UniRef50_D2L986 Diguanylate cyclase n=1 Tax=Desulfovibrio sp. FW1012B
           RepID=D2L986_9DELT
          Length = 530

 Score =  225 bits (574), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 71/260 (27%), Positives = 113/260 (43%), Gaps = 16/260 (6%)

Query: 51  VVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQ 110
           VV+G   ++    P ++         +  L  +               D+    P  I +
Sbjct: 280 VVLGTLATIVLATPLVLRLCRNLERPLEILTGYARSLRAKGYDTTCPPDLGGPMPREIAE 339

Query: 111 MFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYE---ALKSP 167
           +F A   +A               +   +++    +  D LT +Y+R  L+     L   
Sbjct: 340 LFEAFCAMA-------------GEVRGHIEETERLSVLDALTGLYNRRFLFSGGAKLLDA 386

Query: 168 SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFA 227
           S +  +  T ++LD+D+FK+IND++GH  GD+VL+  A  I   V    LVAR GGEEFA
Sbjct: 387 SARAGRPCTCLMLDLDHFKAINDSHGHRTGDQVLAHVAGRIAGAVRRSDLVARYGGEEFA 446

Query: 228 VAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLM 287
           V +   +   G  +AE+IR+ +   P       L +TVSIGV   R          + L+
Sbjct: 447 VLLTGSDRQHGAELAERIRQALADAPCQVGDAYLPVTVSIGVAETRERVQFGESALDDLL 506

Query: 288 VEADTCLYRSKKDGRNRTST 307
             AD  LY +K  GR+R + 
Sbjct: 507 ARADKALYAAKAAGRDRVAA 526


>UniRef50_A9WGU1 Diguanylate cyclase n=3 Tax=Chloroflexus RepID=A9WGU1_CHLAA
          Length = 324

 Score =  225 bits (574), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 65/281 (23%), Positives = 119/281 (42%), Gaps = 7/281 (2%)

Query: 28  VLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGA 87
           V P  +    + AI  I   +  + I       + +   +             ++ +   
Sbjct: 45  VRPVTQGTAALTAIRTIRPDLVLLDIRMPDMDGYEVCQQLKADEETAQIPVIFISALDDV 104

Query: 88  VEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRAD 147
            + V          +  PF   ++ +       +A     +  +   +   + + A  A 
Sbjct: 105 EDKVRAFECGGVDYIAKPFQPLEVLARVRTHLALAQARKALEAANRELQRALAREAELAR 164

Query: 148 FDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVF 204
            D+LT VY+RS  YE  +     + +  + LT+ +LD+D+FK IND YGH  GD+VL   
Sbjct: 165 MDWLTGVYNRSHFYELARHEFAIATRYERPLTMCMLDVDHFKQINDRYGHLVGDQVLRAV 224

Query: 205 ARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLT 264
           A+ +   +     + R GGEEF + +P+ N    L +AE++R  +        +  +  T
Sbjct: 225 AQTVAHQIRTADSIGRFGGEEFILLLPNTNLPSALTLAERLRVTIADLQVHTDRGIVTAT 284

Query: 265 VSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
           +S+GV   +++  T      +L+  AD  LY +K+ GRN  
Sbjct: 285 ISVGVAERQSTDTT----IERLIDRADRALYAAKRQGRNCV 321


>UniRef50_Q2W7A4 Response regulator n=4 Tax=Proteobacteria RepID=Q2W7A4_MAGSA
          Length = 634

 Score =  224 bits (573), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 62/186 (33%), Positives = 99/186 (53%), Gaps = 9/186 (4%)

Query: 132 VAAINSLMKQVALRADFDFLTQVYSRSGLYEA---LKSPSLKQTQHLTVMLLDIDYFKSI 188
           V     LM+ +   +  D +T + +R  L E    L +   ++   LTVM+LD+D+FK +
Sbjct: 448 VLETKRLMETLRESSLSDPMTGLNNRRFLEEYVDTLVANVHRRKSALTVMMLDLDHFKMV 507

Query: 189 NDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKG 248
           ND YGH+ GD VL   ++ +++ V    LV R GGEEF + +      +   +AEKIR  
Sbjct: 508 NDTYGHDAGDAVLKALSKVLRQAVRASDLVIRFGGEEFLIVLVDTPSAEADQVAEKIRAL 567

Query: 249 VELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
           VE         T+  T+SIG+      + T +D F + +  AD  LY++K++GRNR   +
Sbjct: 568 VEALVVQTGTVTIRKTISIGLS----DFPTDSDTFWQAVKFADVALYQAKENGRNRV--V 621

Query: 309 RYGEEV 314
           R+ E +
Sbjct: 622 RFNESM 627


>UniRef50_B8KJJ5 GGDEF domain protein n=2 Tax=unclassified Gammaproteobacteria
           RepID=B8KJJ5_9GAMM
          Length = 540

 Score =  224 bits (573), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 70/268 (26%), Positives = 118/268 (44%), Gaps = 25/268 (9%)

Query: 56  AGSLAFPLPALIWCAVRYTPQV---TCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMF 112
              L   +P  +W     T  +     +   +    E  +V  +V    +G  F+  + F
Sbjct: 269 VLILLLSVPVFLWTLSSVTSPLKNLAAIFRRLAAGSEESVVDAAVTKDEIGDLFNAAEAF 328

Query: 113 SARLGIATMAICP----------IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYE 162
             R  I    +              V+     + +  +++   A  D LT  ++R  L +
Sbjct: 329 R-RENIRERELLADYRELSRTLEAKVTQRTRELEAKNEELDHLASVDKLTDTFNRRALDK 387

Query: 163 ALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVA 219
           AL +    + +  + L+++L+DID FK +ND YGH  GDKVL   ++ I++ +    ++ 
Sbjct: 388 ALLAELERADRYQRPLSILLMDIDLFKQVNDEYGHLTGDKVLVTLSQTIRENLRASDILG 447

Query: 220 RMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTL 279
           R GGEEF V  P  +      +AEK+R+ +E   F   +    +T+SIG+       L  
Sbjct: 448 RWGGEEFLVICPETDLEQARNVAEKVRQAIEGTDFELGK---TITISIGLS-----VLIE 499

Query: 280 TDDFNKLMVEADTCLYRSKKDGRNRTST 307
                 L+ EAD  LY++K  GRNR  T
Sbjct: 500 GTSAESLVAEADKALYQAKSQGRNRVCT 527


>UniRef50_D1U463 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfovibrio
           aespoeensis Aspo-2 RepID=D1U463_9DELT
          Length = 974

 Score =  224 bits (573), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 55/183 (30%), Positives = 93/183 (50%), Gaps = 7/183 (3%)

Query: 128 VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVMLLDIDY 184
           V   +     L +++   A  D LT   +R   +   E     +++    L V++LDIDY
Sbjct: 795 VIHDITERVRLEREMKRLATTDSLTGAANRHEFFRLAELELRRAMRYGHSLAVLMLDIDY 854

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEK 244
           FKSIND +GH+ GD VL   +  ++  + D  +  R+GGEEFA  +P  +   G+L+A++
Sbjct: 855 FKSINDTHGHQTGDAVLKALSALVRTTLRDTDIFGRLGGEEFAAVLPETDLAGGVLVADR 914

Query: 245 IRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           +R+ +       +   +  TVSIG+   R S        +  +  AD  +Y++K+ GRNR
Sbjct: 915 LRRELGALKVRLRDIEVMFTVSIGLTETRKSERL----IDDAINRADEAMYKAKRMGRNR 970

Query: 305 TST 307
             +
Sbjct: 971 VES 973


>UniRef50_C9NRL0 Putative virulence-mediating protein VirC n=2 Tax=Vibrio
           RepID=C9NRL0_9VIBR
          Length = 634

 Score =  224 bits (573), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 56/205 (27%), Positives = 102/205 (49%), Gaps = 3/205 (1%)

Query: 109 PQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEAL-KSP 167
            Q     L I        +V   +  +  + K++  +   D LT + +R  +   L +S 
Sbjct: 432 SQRTREILFITLFFALAYLVIRRLWKMKRITKELESQNTTDPLTGLANRRYIENWLSQSD 491

Query: 168 SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFA 227
           +++Q +   + ++DID+FK  ND +GH+ GD VL   A  ++       ++AR GGEEF 
Sbjct: 492 NVQQHKSYALSVIDIDHFKQFNDTHGHDVGDTVLKATANQLKNNTRSHDIIARWGGEEFV 551

Query: 228 VAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLM 287
           + +P  N        E++RK VE       + +L +T+S+G  +    Y  +  D++++ 
Sbjct: 552 MIIPIDNVHTVEETLERLRKSVESHKIHIDEDSLAVTISVG--TQLCHYQDIETDWDRVF 609

Query: 288 VEADTCLYRSKKDGRNRTSTMRYGE 312
            +AD  LY++K+ GRN+  T  Y +
Sbjct: 610 RKADKALYQAKQSGRNKCITFHYQD 634


>UniRef50_A9B3D1 Diguanylate cyclase n=2 Tax=Bacteria RepID=A9B3D1_HERA2
          Length = 1774

 Score =  224 bits (573), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 60/191 (31%), Positives = 92/191 (48%), Gaps = 7/191 (3%)

Query: 119  ATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSL---KQTQHL 175
            A + +     +    A   L  QV   A  D LTQV +R   +E  +   +        L
Sbjct: 1586 AELGMVFASQAAIAIANAQLFGQVQRLAITDSLTQVSNRRHFFELAERQWILTCSSDHPL 1645

Query: 176  TVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNP 235
            + M+LD+D+FK +ND+YGH  GD VL   A   +  +    L+ R GGEEFA+ +P  + 
Sbjct: 1646 SAMMLDVDHFKRVNDSYGHSVGDLVLRTVADLCRANLRPSDLLGRYGGEEFAILLPDTDV 1705

Query: 236  VDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLY 295
               L +AE++R  +       +Q ++ LTVSIGV           +    L+  AD  LY
Sbjct: 1706 SAALTIAERLRVAIANHVINHEQASINLTVSIGVTGLS----KDDNSVASLLDRADRGLY 1761

Query: 296  RSKKDGRNRTS 306
             +K+ GR+R +
Sbjct: 1762 IAKETGRDRVT 1772


>UniRef50_A6VUN1 Diguanylate cyclase n=1 Tax=Marinomonas sp. MWYL1
           RepID=A6VUN1_MARMS
          Length = 345

 Score =  224 bits (573), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 75/305 (24%), Positives = 131/305 (42%), Gaps = 21/305 (6%)

Query: 20  MLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVI--------GGAGS-LAFPLPALIWCA 70
           +L LAI   L       + PA  +++S++ +++I        GG  S +A+ LP     A
Sbjct: 47  LLDLAIVTSLYIVVRFNIFPASEIMLSLVVAIIIIIPSFALSGGVNSQVAYLLPLYPVMA 106

Query: 71  VR---YTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIM 127
                Y   +   +    G +   + +  + DI+         +        ++    + 
Sbjct: 107 ALIGGYRESLIITIILTIGVILSTVFSQHITDITGAIYSDQKSIDRGFWLTTSIIFSGVF 166

Query: 128 VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDY 184
             F +     L +Q+      D LT +++R GL          +   +  L+++L+DIDY
Sbjct: 167 GRFFLKRYTELTQQLKNENIQDPLTGLFNRRGLNLHFTKELDSADTTSSPLSLILIDIDY 226

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEK 244
           FK IND YGH+ GD  L   A  + + +    ++AR GGEEF + +P+    + + +AEK
Sbjct: 227 FKKINDMYGHDIGDVCLIEIANTLSQAIRKNDIIARFGGEEFIIILPNTPKNETVAIAEK 286

Query: 245 IRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           ++  +  Q F+    +L +T       G   Y    D+  K++  AD  LYR K  GRN 
Sbjct: 287 LKVLISNQKFSSFNLSLTIT------QGLTEYNKNNDNALKMIKRADKALYRGKDKGRNC 340

Query: 305 TSTMR 309
                
Sbjct: 341 VELSE 345


>UniRef50_B6BII0 GGDEF domain/pas/pac sensor domain protein n=1
           Tax=Campylobacterales bacterium GD 1 RepID=B6BII0_9PROT
          Length = 662

 Score =  224 bits (573), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 54/183 (29%), Positives = 91/183 (49%), Gaps = 11/183 (6%)

Query: 126 IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDI 182
           +  S  +     +  ++   A  D LT +Y+R    E ++   + + +  +   +++ DI
Sbjct: 485 VATSQDITERIEMENKLQKLATIDSLTGIYNRHKTNEEIEIQLAKAKRYDEEFALVMFDI 544

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           D+FK +ND YGH+ GD +L  F+  + K + +     R GGEEF + +P V+  + + +A
Sbjct: 545 DHFKDVNDTYGHDAGDDILKEFSDVVLKHIRESDRFGRWGGEEFMLLLPKVDKDEAIRVA 604

Query: 243 EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           +KIR+ V   PF    K   +TVS+G    R       D    L+   D  LY++K  GR
Sbjct: 605 DKIREFVSRYPF---NKLSRITVSVGASIYR-----ENDTKESLLKRTDEALYQAKSSGR 656

Query: 303 NRT 305
           NR 
Sbjct: 657 NRV 659


>UniRef50_Q21NS3 Diguanylate cyclase n=5 Tax=Alteromonadales RepID=Q21NS3_SACD2
          Length = 319

 Score =  224 bits (572), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 54/189 (28%), Positives = 91/189 (48%), Gaps = 12/189 (6%)

Query: 123 ICPIMVSFSVAAINSLM-----KQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQH 174
           IC I+   +  A+N L       Q+   +  D LT + +R       E       +    
Sbjct: 128 ICLIVYDVTEVAVNRLQIQAANLQLHEISRTDGLTGLLNRKTWELDAEQEYKRFKRHEHP 187

Query: 175 LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVN 234
            ++++ DID+FK+IND+YGH  GD+V+   A  ++  + D  +  R GGEEF + +   +
Sbjct: 188 CSLVMFDIDHFKNINDSYGHPAGDEVIRQTAAAVKSCIRDIDIAGRYGGEEFTIVLSDTD 247

Query: 235 PVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCL 294
               L++AE+IR  ++     ++   +  TVS+GV          T      +  AD  L
Sbjct: 248 TEGALVVAERIRNQIQELTVHYEDFAIQFTVSLGVAQLTQQMTNRT----AWIDCADKAL 303

Query: 295 YRSKKDGRN 303
           Y++KK+GRN
Sbjct: 304 YQAKKNGRN 312


>UniRef50_A6LYL1 Diguanylate cyclase n=1 Tax=Clostridium beijerinckii NCIMB 8052
           RepID=A6LYL1_CLOB8
          Length = 568

 Score =  224 bits (572), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 79/314 (25%), Positives = 138/314 (43%), Gaps = 22/314 (7%)

Query: 11  STGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCA 70
           ST VL +   L   I   +P       +  + L++S+  S +I    +       +I   
Sbjct: 260 STWVLFIYSYLD--IKKHMPILNNFFKLSILFLVLSLYISKIIPDGFTYDILYLQMILVG 317

Query: 71  VRYTPQVTCLLTFVTGA----VEIVLVANSVIDISVGSPFSIP---QMFSARLGIATMA- 122
           +     +     F  G+    V I ++    I   +GS   +      FS     A++  
Sbjct: 318 LYILISIYSYFKFGMGSIYYLVGIFILFTGFIIYILGSYGLLEWNIFAFSTCYPAASIET 377

Query: 123 -ICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVM 178
            +  I +   +     +  ++ L    D LT +Y+R    E + +  L+  +    ++++
Sbjct: 378 LLFTIGIIKQIKHEKEVNTKLQLEVITDKLTNIYNRRYFEETVVNKILQLEKEKSLVSML 437

Query: 179 LLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDG 238
           +LDID+FK +ND YGH  GD VLS  A  I++ +  + ++ R GGEEF   +P  +  + 
Sbjct: 438 VLDIDHFKKVNDTYGHSTGDLVLSETAMIIKQCLRKEDILVRWGGEEFVAVLPFTDSKES 497

Query: 239 LLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSK 298
            ++AE IR  +E   F +  K   +TVSIG+         + +DF+     AD  LY +K
Sbjct: 498 TIIAETIRLSIENHKFKFVNK---ITVSIGIAE-----KDVVEDFHSWFRRADNALYNAK 549

Query: 299 KDGRNRTSTMRYGE 312
           ++GRN        E
Sbjct: 550 ENGRNTVCICYTNE 563


>UniRef50_A3WMD3 Phytochrome sensor diguanylate cyclase/phosphodiesterase n=1
           Tax=Idiomarina baltica OS145 RepID=A3WMD3_9GAMM
          Length = 689

 Score =  224 bits (572), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 55/177 (31%), Positives = 88/177 (49%), Gaps = 11/177 (6%)

Query: 134 AINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSIND 190
            +    +++      D LTQV++R  + + L+       +  + L V+LLDID+FK +ND
Sbjct: 517 ELTEANQRLEHLVHTDALTQVWNRYHMEQTLEEEVKRCKRHGRDLAVILLDIDHFKRVND 576

Query: 191 NYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVE 250
           +YGH+ GDKVL + +  I + +    +  R GGEEF +  P  +      +AE++R+ + 
Sbjct: 577 DYGHDVGDKVLKLISEAIHQWLRSSDVFGRWGGEEFLIIAPETDLESANQLAERLRRRLS 636

Query: 251 LQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
              F    K   +T S GV     S     +D N L+  AD  LY+ K+ GRN    
Sbjct: 637 NLQF---DKVGQVTASFGVAELLPS-----EDRNSLVKRADNALYQVKESGRNSVEV 685


>UniRef50_A4VQF4 GGDEF domain protein n=3 Tax=Proteobacteria RepID=A4VQF4_PSEU5
          Length = 466

 Score =  224 bits (572), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 63/227 (27%), Positives = 105/227 (46%), Gaps = 14/227 (6%)

Query: 83  FVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQV 142
                VE+  +AN    I V S      +    +  + M +  +   F +  +  L  Q+
Sbjct: 242 ATITPVELHQIANRHAPILVESGTDYRLLMQVVVVFSAMLLTSL---FWIRRLRRLNDQL 298

Query: 143 ALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDK 199
            +++  D LT + +R+ L          + +  + L++++LDID+FK IND++GH+ GD+
Sbjct: 299 RIKSQTDSLTGLANRAALDRRFATALEQARRYRRPLSIVMLDIDHFKRINDDFGHQMGDR 358

Query: 200 VLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQK 259
           VL  FA  +   +     V R GGEEF V  P  +    +  AE++ +     PF     
Sbjct: 359 VLRDFAALLDDCLRGSDAVGRWGGEEFLVLCPETSGPQAVQFAERLCEQARAFPFATG-- 416

Query: 260 TLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
            +  T+S GV     S     D  + L+  AD  LYR+K +GR+R  
Sbjct: 417 -VSQTLSAGVAELSPS-----DTPDSLLRRADAALYRAKHEGRDRVC 457


>UniRef50_C6CQG0 Diguanylate cyclase n=7 Tax=Enterobacteriaceae RepID=C6CQG0_DICZE
          Length = 491

 Score =  224 bits (572), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 58/239 (24%), Positives = 106/239 (44%), Gaps = 15/239 (6%)

Query: 74  TPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVA 133
              +   +    G   +V   ++  D  + S        S  + +A + +  + +     
Sbjct: 265 NIFLNTRIIPEFGWKLMVEQNSTPHDRQLWSTLLKNTGISITVSVAMLLLIWLTIG---- 320

Query: 134 AINSLMKQVALRADFDFLTQVYSRSGL---YEALKSPSLKQTQHLTVMLLDIDYFKSIND 190
              +  +++ L A  D LT + +R      +  L+     Q +  +++L+D+DYFK IND
Sbjct: 321 ---AYQRRLELMATTDKLTGLMNRQAFEYVFRTLRIKQSTQHRTFSIILIDLDYFKKIND 377

Query: 191 NYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVE 250
            YGH  GD+VL   AR IQ+ +       R GGEEF + +   +      +AEKIR+ + 
Sbjct: 378 QYGHHVGDRVLVRTARLIQRTIRKTDSACRWGGEEFVLLLADCSRSQAHFIAEKIRRAIR 437

Query: 251 LQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
               + Q + + LT+S G+           +  + L+  AD  LY++K+ GR++     
Sbjct: 438 FALVSHQHQVINLTISCGIAESHP-----GESIDHLVQRADNALYQAKRQGRDQAVIAE 491


>UniRef50_C0QLY1 Two domain sensory box histidine kinase (PAS/PAC domain/GGDEF
           domain protein) n=1 Tax=Desulfobacterium autotrophicum
           HRM2 RepID=C0QLY1_DESAH
          Length = 440

 Score =  224 bits (572), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 56/197 (28%), Positives = 95/197 (48%), Gaps = 8/197 (4%)

Query: 112 FSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQ 171
           FS  L I+      I +   +    ++ K++   A  D LT   +R       +    + 
Sbjct: 244 FSRSLDISGKFSNAIAIIEDITKRKTMEKELEKLATTDPLTGAKNRRSFLNLFEKEMKRS 303

Query: 172 TQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAV 228
            ++   L ++++DID+FK INDN+GHE GDK+L++       ++ D  + AR GGEEF +
Sbjct: 304 KRYNYTLALVMIDIDHFKKINDNFGHETGDKILNLLVAKCHSVLRDSDIFARWGGEEFII 363

Query: 229 AVPSVNPVDGLLMAEKIRKGVELQPFTWQQKT-LYLTVSIGVGSGRASYLTLTDDFNKLM 287
            +P  + +     AE++R  +          T +  TVSIG        +      ++++
Sbjct: 364 LLPETDLLQASSAAERLRGALAQSELRTNDGTNINFTVSIGFTIFGNKNIL----IDEII 419

Query: 288 VEADTCLYRSKKDGRNR 304
            +AD  LY +KK GRNR
Sbjct: 420 KKADKALYLAKKQGRNR 436


>UniRef50_B7IH39 Diguanylate cyclase n=2 Tax=Bacteria RepID=B7IH39_THEAB
          Length = 167

 Score =  224 bits (572), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 54/173 (31%), Positives = 92/173 (53%), Gaps = 11/173 (6%)

Query: 137 SLMKQVALRADFDFLTQVYSRSGLYEALKSPS---LKQTQHLTVMLLDIDYFKSINDNYG 193
            L K++   ++ D LT +Y+R  + E ++       +  +  +++++DID FK IND YG
Sbjct: 2   ELNKKLKYLSERDQLTDLYNRHKMNEEIRKHYYNFKRYGRPFSLLMVDIDKFKKINDTYG 61

Query: 194 HECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP 253
           H  GD+VL   A+ + K +    + +R  GEEF + +   +    + +AEKIRK +E + 
Sbjct: 62  HMVGDEVLKKLAKILVKNIRKTDIASRWVGEEFLILLSETDLEQAIEVAEKIRKTIEKES 121

Query: 254 FTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
           F    K + +TVSIGV       +   +    L++  D  LY++K+ GRNR  
Sbjct: 122 FP---KDIRITVSIGV-----DSVENHEHIKDLLILVDEKLYKAKESGRNRVE 166


>UniRef50_Q1JXC4 Diguanylate cyclase n=1 Tax=Desulfuromonas acetoxidans DSM 684
           RepID=Q1JXC4_DESAC
          Length = 637

 Score =  224 bits (572), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 65/197 (32%), Positives = 106/197 (53%), Gaps = 11/197 (5%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEA---LKSPSLKQTQHLTVMLL 180
             I  S SV     LM  +   +  D +T +++R  L +    L + +L++ +++ +++ 
Sbjct: 444 AYIKQSLSVLEAKRLMNTLRESSLRDPMTGLFNRRFLQDQAGHLIAGTLRRKKNIGLLMC 503

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DID+FK +ND YGH+ GD+VL   +  IQK V +  +V R GGEEF V +  +   D + 
Sbjct: 504 DIDFFKQVNDQYGHDAGDQVLKETSAIIQKSVRESDVVVRFGGEEFLVILTDIEAGDAMS 563

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           +AEKIR  +E + F    + +  T+S+GV      Y   ++ F + +  AD  LYR+K+ 
Sbjct: 564 VAEKIRSNIEDKVFMVGPEKIRKTISLGVSE----YPGDSEGFWQSIKYADVALYRAKET 619

Query: 301 GRNRT----STMRYGEE 313
           GRNR      +M   EE
Sbjct: 620 GRNRALRFEESMWTAEE 636


>UniRef50_C6NZM9 Diguanylate cyclase n=1 Tax=Sideroxydans lithotrophicus ES-1
           RepID=C6NZM9_9PROT
          Length = 379

 Score =  224 bits (571), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 63/195 (32%), Positives = 97/195 (49%), Gaps = 6/195 (3%)

Query: 119 ATMAICPIMVSFSVAAINSLM-KQVALRADFDFLTQVYSRSGLYEALKSPS---LKQTQH 174
           +T  I  +   FS+   NSL  +++ L    D LT +Y+R  L    +  +    +    
Sbjct: 162 STDFIERLANIFSICLENSLNHERLKLVGLTDPLTGIYNRRYLETRCQEEAAHVRRYRSP 221

Query: 175 LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVN 234
           L+ M LDID FK IND++GH  GDK+L      I+  +    ++AR GGEEF V +P   
Sbjct: 222 LSCMFLDIDKFKRINDSFGHNIGDKILCSVTAQIKSQLRSNDVLARYGGEEFVVLLPQTG 281

Query: 235 PVDGLLMAEKIRKGVELQPFTW-QQKTLYLTVSIGVGSGRASYLTLTDDF-NKLMVEADT 292
                 +AE+IR+ V  Q F   ++  L +T+SIGV               ++L+  AD 
Sbjct: 282 IRGACDIAERIRRTVAEQAFQIGREDELKVTISIGVAQAPVDADGDERTVAHQLLAAADE 341

Query: 293 CLYRSKKDGRNRTST 307
            LY +K+ GRN+  +
Sbjct: 342 ALYLAKESGRNKVVS 356


>UniRef50_A6CY69 Putative GGDEF family protein n=1 Tax=Vibrio shilonii AK1
           RepID=A6CY69_9VIBR
          Length = 244

 Score =  224 bits (571), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 57/182 (31%), Positives = 96/182 (52%), Gaps = 6/182 (3%)

Query: 127 MVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFK 186
            ++ +++  + L  ++  +++ D LTQ+ +R   +  L +   K T    ++L+DIDYFK
Sbjct: 68  WLTRNISKRHRLELKLRKQSESDPLTQIANRRYFFSTLAT-ITKSTTPHCLLLMDIDYFK 126

Query: 187 SINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIR 246
            +ND YGH  GD  L      IQ I+      AR+GGEEFA+ +P +       +AE+IR
Sbjct: 127 KVNDTYGHLAGDNTLKEVVARIQDIIRPDDTFARVGGEEFALLLPDIEEHTAYEIAERIR 186

Query: 247 KGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
             +   PF ++Q+T  +T+S+G+   R          N +   AD  LY +K  GRN++ 
Sbjct: 187 CTIADTPFHYEQQTFSITLSVGITQARYQERN-----NHIFSRADDALYIAKSRGRNQSM 241

Query: 307 TM 308
            +
Sbjct: 242 VL 243


>UniRef50_B8JB86 Diguanylate cyclase n=4 Tax=Anaeromyxobacter RepID=B8JB86_ANAD2
          Length = 764

 Score =  224 bits (571), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 59/189 (31%), Positives = 96/189 (50%), Gaps = 7/189 (3%)

Query: 123 ICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKS---PSLKQTQHLTVML 179
           +   M +        L  Q    A  D LT + +     E L +    + +  +  +++L
Sbjct: 569 LVISMHAAQSIDRARLFDQTERLATTDGLTGLTNHRTFQERLDAHLGQAQRYGKRTSLLL 628

Query: 180 LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGL 239
            DID+FKS+ND YGH  GD+VL   AR + +      +VAR GGEEFA+ +P  +    +
Sbjct: 629 CDIDHFKSVNDTYGHPVGDQVLRGVARTLARAARGTDVVARYGGEEFAIVMPETDTGGAM 688

Query: 240 LMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKK 299
           ++AE+IR+ V    F  +Q  L +T+S+GV +    +         L+  AD CLY +K+
Sbjct: 689 VIAERIREKVGQLVFETEQGPLKVTLSLGVAT----FPDDGAQKPALIERADACLYHAKR 744

Query: 300 DGRNRTSTM 308
            GRN++ + 
Sbjct: 745 HGRNQSVSA 753


>UniRef50_C5T761 Diguanylate cyclase n=1 Tax=Acidovorax delafieldii 2AN
           RepID=C5T761_ACIDE
          Length = 398

 Score =  224 bits (571), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 63/266 (23%), Positives = 115/266 (43%), Gaps = 18/266 (6%)

Query: 55  GAGSLAFPLPALIWCAVRYT-----PQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIP 109
             G + F +   +             +   LL  +   +  +L     + I VG    + 
Sbjct: 121 ALGGILFAIQGFLVAREVLRRDNGVLERGRLLLAIGAGMVSLLYLQRTLGI-VGGWNEVA 179

Query: 110 QMFSARL---GIATMAICPIMVS---FSVAAINSLMKQVALRADFDFLTQVYSRSGLYEA 163
           Q+ +A     G   M +  +++S   F +        +   +A  D LT V +R  L   
Sbjct: 180 QLKTAHFIQVGSHAMGLAGLVLSTMGFILMGRERADAEHQQQALLDPLTGVPNRRALMAE 239

Query: 164 LKS---PSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVAR 220
           L+     ++++ + + ++++DID FK +ND YGH  GD VL+  A+ ++  +  +  + R
Sbjct: 240 LERTLAQAVRERRPVALLMMDIDRFKRVNDTYGHVAGDAVLAAVAQCLKGGLRGQDFIGR 299

Query: 221 MGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLT 280
            GGEEF   +P  +     ++AE +R  VE     W+ + + +TVSIG            
Sbjct: 300 YGGEEFLALLPGTDAAGAGVVAEHLRARVERLTMPWEPEDIRVTVSIG---AHTRVPDEG 356

Query: 281 DDFNKLMVEADTCLYRSKKDGRNRTS 306
                ++  AD  +Y +K+ GRNR  
Sbjct: 357 TGAQAMVDVADQAMYAAKRAGRNRVE 382


>UniRef50_A1U4U5 Diguanylate cyclase n=2 Tax=Marinobacter RepID=A1U4U5_MARAV
          Length = 571

 Score =  224 bits (571), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 78/318 (24%), Positives = 136/318 (42%), Gaps = 30/318 (9%)

Query: 13  GVLIVPCMLTLAIPGVLPRFKAEQM-------MPAIALIVSVIASVVIGGAGSLAFPLPA 65
            ++ +P  L L +  +    +  +        M A+ ++  V     I  A   A  L A
Sbjct: 248 SLITMPIFLLLFMMAIFETHEYFRTEHRVLQGMLALLVVTFVYGLFDIATALKPASSLAA 307

Query: 66  LIWCAVRYTPQVTC------LLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIA 119
           L+   V ++  ++       L+ F        +V N    +          + S  +GI 
Sbjct: 308 LM-MVVTFSVSISLFRKGHPLVKFFLVGHTFFVVFNGFAVLYYKGLVQPNYINSHGVGIG 366

Query: 120 TMAICPIMVSFSVA-------AINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSL 169
            + +  + ++F ++        I S   ++  +A  D LT++++R       E +   + 
Sbjct: 367 -IVLEALTLAFIISYRIKVLEDIRSKQDELKRQASTDPLTRLFNRRYFMAEGEYVLEQAR 425

Query: 170 KQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVA 229
              + L+V+ +DID+FK++ND +GH  GD VL   A   ++   D+ LVAR GGEEF + 
Sbjct: 426 TSGEPLSVIAIDIDHFKAVNDTHGHNVGDLVLVEVASVFRQFSRDRDLVARFGGEEFVIL 485

Query: 230 VPSVNPVDGLLMAEKIRKGVELQPFTWQQK-TLYLTVSIGVGSGRASYLTLTDDFNKLMV 288
           +P  +  +G   AE+IR  VE           + +TVS+GV         L +     + 
Sbjct: 486 LPGADLTEGFGCAERIRNAVEAMVIDGGDGLAVRVTVSVGVAEVNP----LLESVEGAVK 541

Query: 289 EADTCLYRSKKDGRNRTS 306
            AD  LY +K  GRNR  
Sbjct: 542 RADRSLYEAKAGGRNRVC 559


>UniRef50_C1TNZ5 Diguanylate cyclase (GGDEF) domain-containing protein n=1
           Tax=Dethiosulfovibrio peptidovorans DSM 11002
           RepID=C1TNZ5_9BACT
          Length = 481

 Score =  224 bits (571), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 62/205 (30%), Positives = 94/205 (45%), Gaps = 8/205 (3%)

Query: 107 SIPQMFSARLGIATMA---ICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEA 163
            + +     L I  +    I  ++ S     + +  ++V   A  D LT +++R     A
Sbjct: 282 DVTKAIRHTLAINILVGGLITLVVTSLVALIVRNYERRVERLASVDELTGMWNRRAFDLA 341

Query: 164 LKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGG 223
                 K     +V ++DID+FK +ND YGH  GD+VL      + K +G   +  R GG
Sbjct: 342 FAHLLEKFEGQCSVTMMDIDHFKHVNDTYGHLMGDRVLGHVCDVVTKAIGPDDVCGRWGG 401

Query: 224 EEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDF 283
           EEF V +      D +  AEKIR+ VE  P+      L +TVS+GV           +  
Sbjct: 402 EEFIVLLKGRKKGDAVKTAEKIRRAVEASPYEDGDVVLPITVSLGVAEHHP-----GESR 456

Query: 284 NKLMVEADTCLYRSKKDGRNRTSTM 308
              +  AD  LYR+K+ GRNRT + 
Sbjct: 457 ETTIARADQALYRAKESGRNRTESA 481


>UniRef50_B3QU32 Diguanylate cyclase and serine/threonine protein kinase with TPR
           repeats n=1 Tax=Chloroherpeton thalassium ATCC 35110
           RepID=B3QU32_CHLT3
          Length = 606

 Score =  223 bits (570), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 57/195 (29%), Positives = 98/195 (50%), Gaps = 15/195 (7%)

Query: 121 MAICPIMVSFSVAAINSLMKQVALRADF-------DFLTQVYSRSGLYEALK---SPSLK 170
           + +  + +  + A    L++++  +A+        D LT + +R    E  +     + +
Sbjct: 415 LEVTTLALKEANAENQLLLERLREQAETLERLVTYDGLTGLANRRHFDEQFEYEFRRTRR 474

Query: 171 QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAV 230
             + L++ + DID+FK +NDN+ H+ GD+VL   A   ++ V    LVAR GGEEF    
Sbjct: 475 YKRPLSIAMSDIDFFKKVNDNFSHQVGDEVLKKVASIFRENVRAGDLVARYGGEEFVFIF 534

Query: 231 PSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEA 290
              N    +  AEKIRK +E   ++     L +T+SIGV           D  ++L+  A
Sbjct: 535 TETNKESAIRAAEKIRKAIEDYDWSNVHAGLKVTISIGVAEDAG-----FDGCDELIAAA 589

Query: 291 DTCLYRSKKDGRNRT 305
           D+ LY +K++GRN+ 
Sbjct: 590 DSKLYEAKRNGRNQV 604


>UniRef50_A1SRM4 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Psychromonas
            ingrahamii 37 RepID=A1SRM4_PSYIN
          Length = 1078

 Score =  223 bits (570), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 58/188 (30%), Positives = 93/188 (49%), Gaps = 13/188 (6%)

Query: 126  IMVSF--SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLL 180
            IMV F   V     + +++ L A  D LT + +R      L S   +  +    L++++ 
Sbjct: 899  IMVGFFHDVTERKKVEEEIKLLATTDSLTGIANRRAFSTHLASELERSNRYGTPLSLVMF 958

Query: 181  DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
            DIDYFK +NDN+GH+ GD VL   +  +++ +    +VAR GGEEF + +P  +      
Sbjct: 959  DIDYFKKVNDNFGHDAGDDVLQALSELVKRNIRAVDIVARWGGEEFMLLMPESDISAATA 1018

Query: 241  MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
              EK+R+ +   PF    +   LTVS G+         L +D    +   D  LY++K+ 
Sbjct: 1019 AIEKLRREISDFPF---GQVGSLTVSFGITVF-----VLNEDSKVFLKRVDDALYQAKEK 1070

Query: 301  GRNRTSTM 308
            GRNR   +
Sbjct: 1071 GRNRVEIL 1078


>UniRef50_Q2BQL8 Probable two-component response regulator n=1 Tax=Neptuniibacter
           caesariensis RepID=Q2BQL8_9GAMM
          Length = 505

 Score =  223 bits (570), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 69/295 (23%), Positives = 128/295 (43%), Gaps = 17/295 (5%)

Query: 32  FKAEQMMPAIALIVSVIASVVIGGAGSLAFPLP-----ALIWCAVRYTPQVTCLLTFVTG 86
              E++ P IA + +    ++    G L   L       L+ C  +   ++  L   +T 
Sbjct: 214 HGIEKIWPMIATLRNEFNILLPSSKGELTTLLAEDQPDLLLLCTEQQWQEMLSLCQEITA 273

Query: 87  AVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMK---QVA 143
             +   +  + +   +     +    +      T+   P ++   +  +  L +   Q+A
Sbjct: 274 NKDDYTLPVAFVSADLDDQRELDAYNAGAADFLTLNRAPAVLQSRIQILMQLKQSQDQLA 333

Query: 144 LRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKV 200
             A  D LTQV +R      ++     + +  + L +++LDID+FK  ND YGH  GD  
Sbjct: 334 RSARVDGLTQVNNRREFERNIEMEWRRAQRSKRSLALIMLDIDHFKPFNDGYGHLAGDGC 393

Query: 201 LSVFARHIQKIV-GDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ-- 257
           L   A+ I+  +   + +V R GGEEF V +P  +     ++AE+IRK +       +  
Sbjct: 394 LRTVAQTIKHSIQRAQDMVCRYGGEEFVVILPETDLDGAQMIAERIRKAIAKLKINHEFS 453

Query: 258 QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGE 312
                +T+S GV     S        ++L++ AD  LY++K  GRN+ + ++  E
Sbjct: 454 STDNTITISAGVACLSPSQ---EGSPHELILLADQGLYQAKAQGRNQVAIVQTSE 505


>UniRef50_A1RG31 Diguanylate cyclase n=3 Tax=Shewanella RepID=A1RG31_SHESW
          Length = 362

 Score =  223 bits (570), Expect = 5e-57,   Method: Composition-based stats.
 Identities = 71/288 (24%), Positives = 135/288 (46%), Gaps = 17/288 (5%)

Query: 26  PGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALI--WCAVRYTPQVTCLLTF 83
           P  LP       +   +   S+ + +++G      + L A I    A  + P    L+  
Sbjct: 78  PKQLPPIIQWSWVVVFSQ--SLSSVLILGADAGFQYYLLATIPPSFASIFKPLFYKLIQA 135

Query: 84  VTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAIN---SLMK 140
           +   +   L+ +              +M S    I  +  C ++   S A      S + 
Sbjct: 136 LI-IIVFFLICDIWFIDYEPYYLYSDEMISLFRHINVLGACALLAGVSYAYSQIVMSAIT 194

Query: 141 QVALRADFDFLTQVYSRS---GLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECG 197
            +   A+ D LT + +R     L +   + +L+    ++++L DIDYFK IND+YGH  G
Sbjct: 195 ALRNVANTDELTGLINRRSLTALIDREAARTLRTHASMSLVLCDIDYFKRINDSYGHAAG 254

Query: 198 DKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ 257
           D VL   A  +Q ++ +  +VAR GGEEF + +P+ + ++ + +AE++R+ V     +++
Sbjct: 255 DHVLVNVANLLQGVLREYDVVARWGGEEFLLLLPNTDIIEAMKVAERLREIVACSHLSFE 314

Query: 258 QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
           ++T+ +T+++GV           ++++  +  AD  LYR K+ GRN  
Sbjct: 315 EQTIPVTMTLGVAVL------GDENWHSTLARADEALYRGKRQGRNCV 356


>UniRef50_A9L0C9 Diguanylate cyclase n=2 Tax=Shewanella baltica RepID=A9L0C9_SHEB9
          Length = 466

 Score =  223 bits (570), Expect = 5e-57,   Method: Composition-based stats.
 Identities = 77/309 (24%), Positives = 150/309 (48%), Gaps = 19/309 (6%)

Query: 10  FSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPAL-IW 68
           +  G +++P + +LA+   L        +P +    S    ++      L + L AL + 
Sbjct: 152 WLWGFVLIPVLCSLAL--ALFATWGSHWLPILIAKNSYK-QLLHSPYALLVWGLNALALV 208

Query: 69  CAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIA---TMAICP 125
           C +R       L T+++ A+   L+ +  + +  G+ FS+   ++AR+  +    + +C 
Sbjct: 209 CMIRRARSNNVLYTWLSVALLASLI-DVTLTLFAGARFSLG-WYAARISSSVSSMVLLCA 266

Query: 126 IM--VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLL 180
           ++  V+    A     + +  ++  D LT +++R  L   L      + +  + L +++L
Sbjct: 267 LLWEVNRLYVATQRANESLYQQSVKDTLTGLFNRRYLESQLAIHIDHAKRHKEPLCLLVL 326

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIV-GDKGLVARMGGEEFAVAVPSVNPVDGL 239
           D+D+FK+ ND +GH  GD  L   A+ +++ +      +AR GGEEF V +P  +  DG+
Sbjct: 327 DVDHFKAFNDQHGHLAGDDCLVTVAKQLEQSLYRPADFIARYGGEEFIVVLPHTDAKDGM 386

Query: 240 LMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKK 299
            +AE++R  V  +   +Q + L +T+SIG    R S     +    L++ AD+ LY++K 
Sbjct: 387 QIAERLRLNVSAEKIEYQGQLLSVTISIGCAVLRHS----EETAQSLLIAADSALYQAKA 442

Query: 300 DGRNRTSTM 308
            GRN     
Sbjct: 443 AGRNCVKVA 451


>UniRef50_A0YVN1 PleD-like protein n=2 Tax=Cyanobacteria RepID=A0YVN1_9CYAN
          Length = 1252

 Score =  223 bits (570), Expect = 5e-57,   Method: Composition-based stats.
 Identities = 56/222 (25%), Positives = 109/222 (49%), Gaps = 11/222 (4%)

Query: 91   VLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDF 150
            ++   + + +   +  +  Q+  A+  +A   +  + ++    A   L ++   ++  D 
Sbjct: 1034 MMAQGNTLGLLYIATLTPGQLTPAKRQLARTVVEHLAIAL---ANVKLQEKFKAQSMRDA 1090

Query: 151  LTQVYSRSGLYEALKSPSLKQTQ-HLTV--MLLDIDYFKSINDNYGHECGDKVLSVFARH 207
            LT +++R  L E+L+    +  + H +V  +++DID+FK  ND +GH+ GD+VL   AR 
Sbjct: 1091 LTGLFNRRYLEESLEQEIHRARRNHYSVGIVMIDIDHFKRFNDQFGHDAGDEVLKTVARL 1150

Query: 208  IQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTL-YLTVS 266
            +Q  +    +  R GGEE  + +P  +  D    +E+IR  +E     ++ ++L  +T S
Sbjct: 1151 LQGSIRSSDIACRYGGEELTLILPEASLSDTQARSEQIRYMIEHLQLHYENQSLGSITAS 1210

Query: 267  IGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
             GV      +    +    ++  ADT LY++K  GRNR    
Sbjct: 1211 FGVAC----FPEHGETLEAVLRIADTALYQAKALGRNRVVCA 1248


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q8XAZ4 Uncharacterized protein yneF n=65 Tax=Enterobact...   369   e-101
UniRef50_D2TIF8 Putative signal transduction protein n=2 Tax=Ent...   342   9e-93
UniRef50_A8A075 Diguanylate cyclase (GGDEF) domain protein n=2 T...   322   1e-86
UniRef50_B1JAS6 Diguanylate cyclase n=5 Tax=Pseudomonas RepID=B1...   302   1e-80
UniRef50_D0IXN6 Diguanylate cyclase n=2 Tax=Comamonas testostero...   291   2e-77
UniRef50_C6CDM3 Diguanylate cyclase n=1 Tax=Dickeya dadantii Ech...   282   1e-74
UniRef50_A0P392 GGDEF domain protein n=1 Tax=Labrenzia aggregata...   276   7e-73
UniRef50_C8QCH2 Diguanylate cyclase n=1 Tax=Pantoea sp. At-9b Re...   276   7e-73
UniRef50_B5JW02 Diguanylate cyclase n=1 Tax=gamma proteobacteriu...   274   3e-72
UniRef50_A8GAZ5 Diguanylate cyclase n=2 Tax=Serratia RepID=A8GAZ...   273   6e-72
UniRef50_A8V0B5 Diguanylate cyclase (GGDEF domain) n=1 Tax=Hydro...   269   9e-71
UniRef50_D0FTB2 Conserved uncharacterized protein YneF n=3 Tax=E...   268   2e-70
UniRef50_C6CM30 Diguanylate cyclase n=1 Tax=Dickeya zeae Ech1591...   268   2e-70
UniRef50_C6RK39 Diguanylate cyclase n=2 Tax=Acinetobacter radior...   267   3e-70
UniRef50_D0S942 Response regulator n=2 Tax=Acinetobacter RepID=D...   267   3e-70
UniRef50_D2C311 Diguanylate cyclase n=1 Tax=Dickeya dadantii Ech...   265   2e-69
UniRef50_C6DKF8 Diguanylate cyclase n=5 Tax=Pectobacterium RepID...   265   2e-69
UniRef50_B7GZC2 Uncharacterized protein yneF n=10 Tax=Acinetobac...   265   2e-69
UniRef50_B8FCK6 Response regulator receiver modulated diguanylat...   264   3e-69
UniRef50_Q4KDW8 GGDEF domain protein n=6 Tax=Pseudomonas RepID=Q...   263   8e-69
UniRef50_B8DLP9 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   262   1e-68
UniRef50_C6WYA7 Diguanylate cyclase with PAS/PAC and GAF sensors...   261   3e-68
UniRef50_B4U6Y8 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   260   4e-68
UniRef50_C1SIQ7 Diguanylate cyclase (GGDEF) domain-containing pr...   260   4e-68
UniRef50_B5JX81 Diguanylate cyclase n=1 Tax=gamma proteobacteriu...   260   5e-68
UniRef50_Q30QX5 Diguanylate cyclase n=2 Tax=Proteobacteria RepID...   259   9e-68
UniRef50_Q39ZK6 Response regulator receiver modulated diguanylat...   258   1e-67
UniRef50_D1U434 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   258   2e-67
UniRef50_A9WGU1 Diguanylate cyclase n=3 Tax=Chloroflexus RepID=A...   258   2e-67
UniRef50_A9C2H0 Diguanylate cyclase n=2 Tax=cellular organisms R...   257   3e-67
UniRef50_A8FZ07 Diguanylate cyclase n=2 Tax=Shewanella RepID=A8F...   257   3e-67
UniRef50_Q21HV6 Response regulator receiver modulated diguanylat...   257   4e-67
UniRef50_C6NZP2 Periplasmic/7TM domain sensor diguanylate cyclas...   257   4e-67
UniRef50_C1XLF8 Diguanylate cyclase (GGDEF) domain-containing pr...   256   5e-67
UniRef50_A3J8Q2 Two-component response regulator protein n=1 Tax...   256   7e-67
UniRef50_Q3ADQ4 Response regulator/sensory box protein/GGDEF dom...   256   8e-67
UniRef50_C6WYA9 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   256   9e-67
UniRef50_A8ZX32 Diguanylate cyclase n=1 Tax=Desulfococcus oleovo...   256   9e-67
UniRef50_A8GES9 Diguanylate cyclase n=2 Tax=Serratia RepID=A8GES...   256   9e-67
UniRef50_B4VVS2 GGDEF domain protein n=1 Tax=Microcoleus chthono...   255   2e-66
UniRef50_B3E6Y7 Diguanylate cyclase n=1 Tax=Geobacter lovleyi SZ...   255   2e-66
UniRef50_B3EBI3 Diguanylate cyclase n=1 Tax=Geobacter lovleyi SZ...   255   2e-66
UniRef50_B8DLV9 Diguanylate cyclase n=4 Tax=Desulfovibrio vulgar...   255   2e-66
UniRef50_C6C0X5 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   254   3e-66
UniRef50_C6BW86 Diguanylate cyclase n=1 Tax=Desulfovibrio salexi...   254   3e-66
UniRef50_C6DJJ8 Diguanylate cyclase n=1 Tax=Pectobacterium carot...   254   3e-66
UniRef50_C8X5B9 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   254   3e-66
UniRef50_A0YVG8 GGDEF/response regulator receiver domain protein...   253   4e-66
UniRef50_B7K273 Response regulator receiver modulated diguanylat...   253   5e-66
UniRef50_A1U2H0 Diguanylate cyclase n=2 Tax=Marinobacter RepID=A...   253   5e-66
UniRef50_C0N773 GGDEF domain protein n=1 Tax=Methylophaga thioox...   253   5e-66
UniRef50_Q310L5 Diguanylate cyclase (GGDEF domain) n=2 Tax=Desul...   253   6e-66
UniRef50_C3JIZ7 Diguanylate cyclase n=2 Tax=Rhodococcus erythrop...   253   6e-66
UniRef50_B1WQB8 Putative diguanylate cyclase n=2 Tax=Cyanothece ...   253   7e-66
UniRef50_A4BG19 GGDEF domain protein n=1 Tax=Reinekea blandensis...   253   7e-66
UniRef50_C6BVV0 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   253   9e-66
UniRef50_A1TWP6 Diguanylate cyclase n=2 Tax=Marinobacter RepID=A...   252   1e-65
UniRef50_C0QT79 Signal transduction response regulator n=1 Tax=P...   252   1e-65
UniRef50_Q1N175 Diguanylate cyclase (GGDEF domain) n=1 Tax=Berma...   252   1e-65
UniRef50_C5SA57 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   252   1e-65
UniRef50_D2L2K3 Diguanylate cyclase with GAF sensor n=1 Tax=Desu...   252   1e-65
UniRef50_A3Y6S3 PAS:GGDEF protein n=1 Tax=Marinomonas sp. MED121...   252   1e-65
UniRef50_D1U9C4 Diguanylate cyclase n=1 Tax=Desulfovibrio aespoe...   252   1e-65
UniRef50_Q2VYV6 FOG: GGDEF domain n=2 Tax=Magnetospirillum RepID...   251   2e-65
UniRef50_A1AK55 Diguanylate cyclase with PAS/PAC sensor n=2 Tax=...   251   2e-65
UniRef50_A5GCU4 Diguanylate cyclase n=2 Tax=Geobacter RepID=A5GC...   251   2e-65
UniRef50_Q47Y21 GGDEF domain protein n=1 Tax=Colwellia psychrery...   251   2e-65
UniRef50_Q15V65 Diguanylate cyclase n=1 Tax=Pseudoalteromonas at...   251   2e-65
UniRef50_Q47W79 GGDEF domain protein n=1 Tax=Colwellia psychrery...   251   3e-65
UniRef50_Q1JXK3 Diguanylate cyclase n=1 Tax=Desulfuromonas aceto...   251   3e-65
UniRef50_Q0EXC8 Signal transduction protein containing a membran...   250   4e-65
UniRef50_A1U7E6 Diguanylate cyclase n=1 Tax=Marinobacter aquaeol...   250   4e-65
UniRef50_D0SXM5 Predicted protein n=2 Tax=Acinetobacter lwoffii ...   250   5e-65
UniRef50_B8DIJ3 Diguanylate cyclase with PAS/PAC and GAF sensors...   250   6e-65
UniRef50_B8FMG8 Diguanylate cyclase n=1 Tax=Desulfatibacillum al...   250   6e-65
UniRef50_B7R5U6 PAS fold family protein n=13 Tax=Thermoanaerobac...   250   6e-65
UniRef50_A3WKT4 GGDEF domain protein n=2 Tax=Alteromonadales Rep...   250   6e-65
UniRef50_D0KF92 Diguanylate cyclase n=1 Tax=Pectobacterium wasab...   250   7e-65
UniRef50_Q085X7 Diguanylate cyclase n=2 Tax=Alteromonadales RepI...   250   7e-65
UniRef50_A6DDS7 Diguanylate cyclase (GGDEF domain) n=1 Tax=Camin...   250   7e-65
UniRef50_C0QM24 Putative uncharacterized protein n=1 Tax=Desulfo...   249   7e-65
UniRef50_C4XS30 GGDEF domain protein n=1 Tax=Desulfovibrio magne...   249   8e-65
UniRef50_A8TM57 Putative diguanylate cyclase (GGDEF domain) with...   249   1e-64
UniRef50_B8GRD6 Diguanylate cyclase n=1 Tax=Thioalkalivibrio sp....   249   1e-64
UniRef50_A1U4U5 Diguanylate cyclase n=2 Tax=Marinobacter RepID=A...   248   1e-64
UniRef50_C9YC42 Putative uncharacterized protein n=1 Tax=Curviba...   248   1e-64
UniRef50_Q2SME0 Response regulator containing a CheY-like receiv...   248   1e-64
UniRef50_C7R6Y0 Diguanylate cyclase n=1 Tax=Kangiella koreensis ...   248   1e-64
UniRef50_C4XPG9 GGDEF domain protein n=1 Tax=Desulfovibrio magne...   248   2e-64
UniRef50_Q3IJX5 Putative uncharacterized protein n=2 Tax=Alterom...   248   2e-64
UniRef50_Q30WV4 Diguanylate cyclase (GGDEF domain) with PAS/PAC ...   248   2e-64
UniRef50_C7LRA7 Diguanylate cyclase n=1 Tax=Desulfomicrobium bac...   248   2e-64
UniRef50_C8WZ84 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   248   2e-64
UniRef50_A3WKY5 Signaling protein with a ligand-binding sensor d...   248   2e-64
UniRef50_A1WM32 Diguanylate cyclase n=2 Tax=Burkholderiales RepI...   248   2e-64
UniRef50_C7LVZ4 Diguanylate cyclase n=1 Tax=Desulfomicrobium bac...   248   2e-64
UniRef50_Q1N3P2 Probable two-component response regulator n=1 Ta...   248   2e-64
UniRef50_A6Q2P1 Putative uncharacterized protein n=1 Tax=Nitrati...   248   2e-64
UniRef50_Q30SB7 Diguanylate cyclase (GGDEF domain) n=1 Tax=Sulfu...   248   2e-64
UniRef50_Q2RNW0 Putative diguanylate cyclase (GGDEF domain) n=1 ...   248   2e-64
UniRef50_Q67JR0 Putative uncharacterized protein n=1 Tax=Symbiob...   248   3e-64
UniRef50_Q2BQL8 Probable two-component response regulator n=1 Ta...   248   3e-64
UniRef50_B1KMS8 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   247   3e-64
UniRef50_B3E5R5 Response regulator receiver modulated diguanylat...   247   3e-64
UniRef50_C5T8F5 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   247   3e-64
UniRef50_A1SRL2 Diguanylate cyclase n=1 Tax=Psychromonas ingraha...   247   3e-64
UniRef50_Q0A8G7 Diguanylate cyclase n=1 Tax=Alkalilimnicola ehrl...   247   4e-64
UniRef50_Q2W1M0 Response regulator containing a CheY-like receiv...   247   4e-64
UniRef50_B9ZM04 Diguanylate cyclase n=1 Tax=Thioalkalivibrio sp....   247   5e-64
UniRef50_A4BIU7 Response regulator containing a CheY-like receiv...   247   5e-64
UniRef50_Q315M6 Diguanylate cyclase n=1 Tax=Desulfovibrio desulf...   246   5e-64
UniRef50_C0QBK1 GGDEF domain family protein n=1 Tax=Desulfobacte...   246   6e-64
UniRef50_A0L7F5 Cyclic nucleotide-binding protein n=1 Tax=Magnet...   246   6e-64
UniRef50_UPI0000384142 COG2199: FOG: GGDEF domain n=1 Tax=Magnet...   246   6e-64
UniRef50_B9ZRW3 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   246   7e-64
UniRef50_A3Y5H4 Diguanylate cyclase (GGDEF domain) n=1 Tax=Marin...   246   7e-64
UniRef50_Q087A8 Diguanylate cyclase n=1 Tax=Shewanella frigidima...   246   8e-64
UniRef50_A3WMD3 Phytochrome sensor diguanylate cyclase/phosphodi...   246   9e-64
UniRef50_Q2SNU2 Response regulator containing a CheY-like receiv...   246   9e-64
UniRef50_C6BZS4 Diguanylate cyclase with PAS/PAC and GAF sensors...   246   9e-64
UniRef50_A0L4D8 Diguanylate cyclase n=2 Tax=cellular organisms R...   246   9e-64
UniRef50_B3PIC1 Sensory box/GGDEF family protein n=5 Tax=Gammapr...   246   9e-64
UniRef50_A4VQQ9 GGDEF domain protein n=1 Tax=Pseudomonas stutzer...   246   1e-63
UniRef50_Q489Q4 Sensory box/GGDEF domain protein n=1 Tax=Colwell...   246   1e-63
UniRef50_B0TJ24 Periplasmic/7TM domain sensor diguanylate cyclas...   246   1e-63
UniRef50_A9WIR5 Diguanylate cyclase n=3 Tax=Chloroflexus RepID=A...   245   1e-63
UniRef50_C3JRE9 Diguanylate cyclase n=2 Tax=Rhodococcus erythrop...   245   1e-63
UniRef50_C0QLY1 Two domain sensory box histidine kinase (PAS/PAC...   245   1e-63
UniRef50_Q8DCJ9 FOG: GGDEF domain n=3 Tax=Vibrio RepID=Q8DCJ9_VIBVU   245   1e-63
UniRef50_Q1K485 Diguanylate cyclase n=1 Tax=Desulfuromonas aceto...   245   2e-63
UniRef50_A4XVW9 Periplasmic/7TM domain sensor diguanylate cyclas...   245   2e-63
UniRef50_A4C957 Putative uncharacterized protein n=1 Tax=Pseudoa...   245   2e-63
UniRef50_A1ASG6 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   245   2e-63
UniRef50_C1TNC9 Diguanylate cyclase (GGDEF) domain-containing pr...   245   2e-63
UniRef50_B4U5K2 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   245   2e-63
UniRef50_Q6AJ00 Putative uncharacterized protein n=1 Tax=Desulfo...   245   2e-63
UniRef50_Q21PN7 GGDEF domain n=1 Tax=Saccharophagus degradans 2-...   245   2e-63
UniRef50_B4VK28 GGDEF domain protein n=1 Tax=Microcoleus chthono...   245   2e-63
UniRef50_Q0BZW4 Response regulator PleD n=1 Tax=Hyphomonas neptu...   245   2e-63
UniRef50_C6BU46 Diguanylate cyclase n=1 Tax=Desulfovibrio salexi...   245   2e-63
UniRef50_Q2IX34 Diguanylate cyclase n=5 Tax=Rhodopseudomonas pal...   245   2e-63
UniRef50_Q5P7Y3 Putative uncharacterized protein n=1 Tax=Aromato...   244   2e-63
UniRef50_Q0A5N6 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   244   2e-63
UniRef50_B4UA43 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   244   2e-63
UniRef50_Q31EI0 Diguanylate cyclase (GGDEF domain) n=1 Tax=Thiom...   244   3e-63
UniRef50_Q21NS3 Diguanylate cyclase n=5 Tax=Alteromonadales RepI...   244   3e-63
UniRef50_Q3JE99 Response regulator receiver modulated diguanylat...   244   3e-63
UniRef50_A5D1G5 Hypothetical signaling protein n=1 Tax=Pelotomac...   244   3e-63
UniRef50_C0QQU4 Response regulator receiver modulated diguanylat...   244   3e-63
UniRef50_UPI0001AEC0DE GGDEF domain protein n=1 Tax=Alteromonas ...   244   3e-63
UniRef50_C4XKN6 Putative signaling protein n=2 Tax=Desulfovibrio...   244   3e-63
UniRef50_B9Z0Y0 Diguanylate cyclase n=1 Tax=Lutiella nitroferrum...   244   4e-63
UniRef50_Q2BML0 Putative diguanylate cyclase (GGDEF domain) n=1 ...   244   4e-63
UniRef50_A7BV03 Sensor protein n=2 Tax=Beggiatoa sp. PS RepID=A7...   244   4e-63
UniRef50_Q74AN9 Response regulator n=1 Tax=Geobacter sulfurreduc...   244   4e-63
UniRef50_B8DJ36 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   244   4e-63
UniRef50_Q6ALC0 Putative uncharacterized protein n=1 Tax=Desulfo...   243   4e-63
UniRef50_C1A5L7 Putative two-component response regulator n=1 Ta...   243   4e-63
UniRef50_Q21VE2 Diguanylate cyclase n=1 Tax=Rhodoferax ferriredu...   243   5e-63
UniRef50_B2V6Y8 Diguanylate cyclase n=1 Tax=Sulfurihydrogenibium...   243   5e-63
UniRef50_B6BK11 Ggdef/pas/pac-domain containing protein n=1 Tax=...   243   5e-63
UniRef50_B0C2A6 Diguanylate cyclase (GGDEF domain), putative n=3...   243   5e-63
UniRef50_C6P3N4 Diguanylate cyclase n=1 Tax=Sideroxydans lithotr...   243   5e-63
UniRef50_A7N081 Putative uncharacterized protein n=6 Tax=Vibrio ...   243   5e-63
UniRef50_Q30SY9 Diguanylate cyclase (GGDEF domain) n=1 Tax=Sulfu...   243   6e-63
UniRef50_Q31GI5 Diguanylate cyclase (GGDEF domain) n=1 Tax=Thiom...   243   6e-63
UniRef50_B7VQN9 GGDEF family protein n=1 Tax=Vibrio splendidus L...   243   7e-63
UniRef50_C8X007 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   243   7e-63
UniRef50_Q47C76 PAS:GGDEF n=1 Tax=Dechloromonas aromatica RCB Re...   243   7e-63
UniRef50_A9L0C9 Diguanylate cyclase n=2 Tax=Shewanella baltica R...   243   7e-63
UniRef50_B8KJJ5 GGDEF domain protein n=2 Tax=unclassified Gammap...   243   7e-63
UniRef50_Q5NP17 Diguanylate cyclase with beta propeller sensor n...   243   7e-63
UniRef50_A0LD73 Diguanylate cyclase n=1 Tax=Magnetococcus sp. MC...   242   9e-63
UniRef50_A5V1I0 Diguanylate cyclase with GAF sensor n=2 Tax=Rose...   242   9e-63
UniRef50_A4SM80 GGDEF domain protein n=2 Tax=Aeromonas RepID=A4S...   242   9e-63
UniRef50_Q2BQS0 GGDEF family protein n=1 Tax=Neptuniibacter caes...   242   9e-63
UniRef50_A1TWT4 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   242   1e-62
UniRef50_B0SEM7 GGDEF domain protein n=2 Tax=Leptospira biflexa ...   242   1e-62
UniRef50_Q2BP61 GGDEF/HAMP domain protein n=1 Tax=Neptuniibacter...   242   1e-62
UniRef50_C0QC96 Sensory box histidine kinase (GGDEF domain prote...   242   1e-62
UniRef50_Q31IP8 Diguanylate cyclase (GGDEF domain) with PAS/PAC ...   242   1e-62
UniRef50_Q2BLA2 Putative uncharacterized protein n=1 Tax=Neptuni...   242   1e-62
UniRef50_A6LYL1 Diguanylate cyclase n=1 Tax=Clostridium beijerin...   242   1e-62
UniRef50_B0C0K6 Diguanylate cyclase (GGDEF) domain protein n=3 T...   242   1e-62
UniRef50_B7K319 Response regulator receiver modulated diguanylat...   242   1e-62
UniRef50_A8I8X7 GGDEF domain protein n=2 Tax=cellular organisms ...   242   1e-62
UniRef50_A8HRM0 Putative diguanylate cyclase n=1 Tax=Azorhizobiu...   242   2e-62
UniRef50_Q21JG3 GGDEF domain n=1 Tax=Saccharophagus degradans 2-...   241   2e-62
UniRef50_A1TTA7 Diguanylate cyclase n=2 Tax=Acidovorax RepID=A1T...   241   2e-62
UniRef50_A0Z7X2 Response regulator n=1 Tax=marine gamma proteoba...   241   2e-62
UniRef50_A8UV88 Putative uncharacterized protein n=1 Tax=Hydroge...   241   2e-62
UniRef50_B3QU32 Diguanylate cyclase and serine/threonine protein...   241   2e-62
UniRef50_A1VA66 Diguanylate cyclase with PAS/PAC sensor n=3 Tax=...   241   2e-62
UniRef50_C8QVV3 Diguanylate cyclase n=1 Tax=Desulfurivibrio alka...   241   2e-62
UniRef50_Q0A9X2 Diguanylate cyclase n=3 Tax=Proteobacteria RepID...   241   2e-62
UniRef50_Q1JWQ3 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   241   2e-62
UniRef50_B4RZE8 GGDEF domain protein n=2 Tax=Alteromonadales Rep...   241   3e-62
UniRef50_D1TF13 Response regulator receiver protein n=1 Tax=Burk...   241   3e-62
UniRef50_Q48M78 Sensory box-containing diguanylate cyclase, puta...   241   3e-62
UniRef50_Q7NZV8 Putative uncharacterized protein n=1 Tax=Chromob...   241   3e-62
UniRef50_A0YVN1 PleD-like protein n=2 Tax=Cyanobacteria RepID=A0...   241   3e-62
UniRef50_C9RM68 Diguanylate cyclase n=1 Tax=Fibrobacter succinog...   240   4e-62
UniRef50_A0KXZ1 Diguanylate cyclase n=4 Tax=Shewanella RepID=A0K...   240   4e-62
UniRef50_C5T1B3 Diguanylate cyclase n=1 Tax=Acidovorax delafield...   240   4e-62
UniRef50_Q2SUR3 GGDEF domain protein n=54 Tax=Burkholderiaceae R...   240   5e-62
UniRef50_A4CE22 Response regulator containing a CheY-like receiv...   240   5e-62
UniRef50_D1U463 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   240   5e-62
UniRef50_A8DJI0 Sensor protein n=1 Tax=Candidatus Chloracidobact...   240   5e-62
UniRef50_C6P6Y5 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   240   5e-62
UniRef50_Q2RNX7 Putative diguanylate cyclase (GGDEF domain) with...   240   5e-62
UniRef50_A1RG31 Diguanylate cyclase n=3 Tax=Shewanella RepID=A1R...   240   6e-62
UniRef50_Q1D095 Response regulator/GGDEF domain protein n=3 Tax=...   240   6e-62
UniRef50_A1SRM4 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   240   6e-62
UniRef50_C4KD29 Response regulator receiver modulated diguanylat...   240   7e-62
UniRef50_B1J820 Diguanylate cyclase n=1 Tax=Pseudomonas putida W...   240   7e-62
UniRef50_Q31M78 Diguanylate cyclase (GGDEF domain) with PAS/PAC ...   240   7e-62
UniRef50_B8KV43 Sensory box histidine kinase n=1 Tax=gamma prote...   240   7e-62
UniRef50_A4TZM8 GGDEF domain n=1 Tax=Magnetospirillum gryphiswal...   240   7e-62
UniRef50_A6G7C6 FHA domain/GGDEF domain protein n=1 Tax=Plesiocy...   239   8e-62
UniRef50_B7IH39 Diguanylate cyclase n=2 Tax=Bacteria RepID=B7IH3...   239   9e-62
UniRef50_A9B3D1 Diguanylate cyclase n=2 Tax=Bacteria RepID=A9B3D...   239   9e-62
UniRef50_A1VD57 Diguanylate cyclase n=3 Tax=Desulfovibrio vulgar...   239   9e-62
UniRef50_C6WY37 Diguanylate cyclase n=1 Tax=Methylotenera mobili...   239   9e-62
UniRef50_Q47A94 Diguanylate cyclase n=1 Tax=Dechloromonas aromat...   239   1e-61
UniRef50_A0L8W1 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   239   1e-61
UniRef50_B3PC25 YaiC/YhcK/ArdA family protein n=1 Tax=Cellvibrio...   239   1e-61
UniRef50_B6IN39 Response regulator With diguanylate cyclase (GGD...   239   1e-61
UniRef50_C8X290 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=...   239   1e-61
UniRef50_A8UY29 Putative uncharacterized protein n=1 Tax=Hydroge...   239   1e-61
UniRef50_Q21GT7 GGDEF domain n=1 Tax=Saccharophagus degradans 2-...   239   1e-61
UniRef50_A9FZW1 FHA domain protein n=1 Tax=Sorangium cellulosum ...   239   1e-61
UniRef50_D1U6K0 Diguanylate cyclase with PAS/PAC sensor and heme...   239   1e-61
UniRef50_Q4KKJ4 Diguanylate cyclase, putative n=5 Tax=Pseudomona...   239   1e-61
UniRef50_Q1MYJ5 Response regulator containing a CheY-like receiv...   239   1e-61
UniRef50_C0Z6I5 Putative uncharacterized protein n=1 Tax=Breviba...   238   1e-61
UniRef50_Q6AL41 Putative uncharacterized protein n=1 Tax=Desulfo...   238   1e-61
UniRef50_A3J836 Putative diguanylate cyclase (GGDEF domain) n=1 ...   238   1e-61
UniRef50_A8UWP4 Response regulator containing a CheY-like receiv...   238   2e-61
UniRef50_Q2IZF7 Diguanylate cyclase n=5 Tax=Rhodopseudomonas pal...   238   2e-61
UniRef50_C1F5G2 GAF domain/GGDEF domain protein n=1 Tax=Acidobac...   238   2e-61
UniRef50_Q2SPL3 Response regulator containing a CheY-like receiv...   238   2e-61
UniRef50_C6CQG0 Diguanylate cyclase n=7 Tax=Enterobacteriaceae R...   238   2e-61
UniRef50_B5JS67 Gaf/pas/ggdef domain protein n=1 Tax=gamma prote...   238   2e-61
UniRef50_A8UY33 Putative uncharacterized protein n=1 Tax=Hydroge...   238   2e-61

Sequences not found previously or not previously below threshold:

UniRef50_UPI0001C3940A response regulator receiver modulated dig...   246   7e-64
UniRef50_Q04S93 GGDEF domain receiver component of a two-compone...   246   1e-63
UniRef50_Q30SV7 Diguanylate cyclase (GGDEF domain) with PAS/PAC ...   242   1e-62
UniRef50_B2A6L1 Response regulator receiver modulated diguanylat...   241   2e-62
UniRef50_B1XII1 PleD protein n=3 Tax=Bacteria RepID=B1XII1_SYNP2      240   5e-62
UniRef50_B4VMP7 GGDEF domain protein n=1 Tax=Microcoleus chthono...   240   7e-62

>UniRef50_Q8XAZ4 Uncharacterized protein yneF n=65 Tax=Enterobacteriaceae
           RepID=YNEF_ECO57
          Length = 315

 Score =  369 bits (947), Expect = e-101,   Method: Composition-based stats.
 Identities = 314/315 (99%), Positives = 314/315 (99%)

Query: 1   MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA 60
           MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA
Sbjct: 1   MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA 60

Query: 61  FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT 120
           FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT
Sbjct: 61  FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT 120

Query: 121 MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL 180
           MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL
Sbjct: 121 MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL 180

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL
Sbjct: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASY TLTDDFNKLMVEADTCLYRSKKD
Sbjct: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKD 300

Query: 301 GRNRTSTMRYGEEVV 315
           GRNRTSTMRYGEEVV
Sbjct: 301 GRNRTSTMRYGEEVV 315


>UniRef50_D2TIF8 Putative signal transduction protein n=2 Tax=Enterobacteriaceae
           RepID=D2TIF8_CITRO
          Length = 484

 Score =  342 bits (878), Expect = 9e-93,   Method: Composition-based stats.
 Identities = 245/307 (79%), Positives = 276/307 (89%)

Query: 1   MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA 60
           + ADWFSEQFSTGVLIVPCMLTL IPG + RF+ EQMMP IALIVSV+ASVVIGGAGSLA
Sbjct: 163 LFADWFSEQFSTGVLIVPCMLTLGIPGSVKRFRPEQMMPVIALIVSVLASVVIGGAGSLA 222

Query: 61  FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT 120
           FPLPALIWCAVRYTPQVTCLLTF+TGAVEIVLVANSVI+I+V SP S PQMFSARLGI T
Sbjct: 223 FPLPALIWCAVRYTPQVTCLLTFLTGAVEIVLVANSVINIAVASPLSAPQMFSARLGIVT 282

Query: 121 MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL 180
           MAICPIMV+FSVAAINSLMKQ++LRADFDFLTQVYSRSGLYEALK  +   +Q++TVMLL
Sbjct: 283 MAICPIMVAFSVAAINSLMKQISLRADFDFLTQVYSRSGLYEALKRQAYPASQNMTVMLL 342

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DIDYFKSINDNYGHECGD+VL VFARHIQ+IVGD+GLVARMGGEEFAV +P+ +P +G+ 
Sbjct: 343 DIDYFKSINDNYGHECGDRVLCVFARHIQRIVGDRGLVARMGGEEFAVVLPTSHPEEGMQ 402

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           +AE IRK V LQPF WQQ+++YLTVSIGVG+G+ +  T+TD FNKLMVEAD CLYRSK +
Sbjct: 403 LAETIRKAVALQPFDWQQQSIYLTVSIGVGNGKIAAQTVTDIFNKLMVEADECLYRSKNE 462

Query: 301 GRNRTST 307
           GRNRTS 
Sbjct: 463 GRNRTSA 469


>UniRef50_A8A075 Diguanylate cyclase (GGDEF) domain protein n=2
           Tax=Enterobacteriaceae RepID=A8A075_ECOHS
          Length = 279

 Score =  322 bits (825), Expect = 1e-86,   Method: Composition-based stats.
 Identities = 278/279 (99%), Positives = 278/279 (99%)

Query: 37  MMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANS 96
           MMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANS
Sbjct: 1   MMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANS 60

Query: 97  VIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYS 156
           VIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYS
Sbjct: 61  VIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYS 120

Query: 157 RSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKG 216
           RSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKG
Sbjct: 121 RSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKG 180

Query: 217 LVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASY 276
           LVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASY
Sbjct: 181 LVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASY 240

Query: 277 LTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV 315
            TLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
Sbjct: 241 RTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV 279


>UniRef50_B1JAS6 Diguanylate cyclase n=5 Tax=Pseudomonas RepID=B1JAS6_PSEPW
          Length = 469

 Score =  302 bits (774), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 119/319 (37%), Positives = 176/319 (55%), Gaps = 10/319 (3%)

Query: 5   WFSEQFSTGVLIVPCMLTLAIPGVLPR--FKAEQMMPAIALIVSVIASVVIGGAGSLAFP 62
           WFSEQFST VL++P +LT      L R   +A  + P + L+ S+  S+  GG G++AFP
Sbjct: 153 WFSEQFSTAVLLLPVLLTAPSARALVRSGAQAVALAPLLVLLASLAFSIAFGGPGAIAFP 212

Query: 63  LPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVG-SPFSIPQMFSARLGIATM 121
           + AL+WCA  Y+P +  LLT + G+  IV VA +++  SV  S   +  + SAR+GIA +
Sbjct: 213 IAALLWCAWTYSPFLVSLLTLIAGSTLIVAVAQNLMHFSVPQSELGVTTLMSARMGIAML 272

Query: 122 AICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPS-LKQTQ----HLT 176
            + P++V+    A  SL+ ++A +A  D LT   +RS       +    +Q       LT
Sbjct: 273 ILGPLVVACVSQANRSLLARLAHQATIDHLTGALTRSAFTRRANALLDSRQKHAQALPLT 332

Query: 177 VMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPV 236
           +M+LDID+FKSIND +GH  GD+VL  FAR +Q  +    L+ARMGGEEF V +P + P 
Sbjct: 333 LMMLDIDHFKSINDRHGHGVGDQVLRQFARTLQDQLHGGELLARMGGEEFVVLLPGLAPE 392

Query: 237 DGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYR 296
                AE++R+ V+            +TVSIG+              ++L+  AD  LYR
Sbjct: 393 RASFTAERLRRAVQDLHLAKGDGRPQITVSIGLDGCAGHEPAP--TLDELLARADQALYR 450

Query: 297 SKKDGRNRTSTMRYGEEVV 315
           +K  GRNR        +V+
Sbjct: 451 AKAHGRNRVEVAETQRQVI 469


>UniRef50_D0IXN6 Diguanylate cyclase n=2 Tax=Comamonas testosteroni
           RepID=D0IXN6_COMTE
          Length = 473

 Score =  291 bits (746), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 92/314 (29%), Positives = 163/314 (51%), Gaps = 13/314 (4%)

Query: 2   LADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAE-----QMMPAIALIVSVIASVVIGGA 56
            + W S ++   ++ +P +L             E     +++P +++I     S  I G 
Sbjct: 162 FSMWLSSEWLNYMMFLPIVLAWPTRKQPVGHLGEPSPLRRILPLLSVIALEAISYWIKGP 221

Query: 57  GSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARL 116
           GSLAF LPALIWCA+ Y      L+T       I+ ++   ++ +   P    +  S R+
Sbjct: 222 GSLAFSLPALIWCALSYRIFSLTLITATLCLSSIIFISLGTLEFT---PAHFLETLSFRM 278

Query: 117 GIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQ 173
           G+  + + P+ V+ S  A N LM++++   + DFLT + +R       + +     +  Q
Sbjct: 279 GLCMLVLGPLAVAGSHMARNELMQKLSHAVNHDFLTDMLARGAFMKQGQRILERCRQDGQ 338

Query: 174 HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSV 233
              +++LD+D+FK IND++GH  GD++L  F++ + +++  + +V RMGGEEFAVA+P V
Sbjct: 339 PFAILMLDLDHFKQINDSFGHAGGDQLLRSFSQTLSQVLRAQDIVGRMGGEEFAVALPKV 398

Query: 234 NPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTC 293
           +      +A++I + +         KT+  TVSIG+    +  L      + L+++AD  
Sbjct: 399 DASAAQEIAKRINRAIRELRVPMNDKTMSATVSIGLVHTTS--LQAHQSLDMLLLQADQA 456

Query: 294 LYRSKKDGRNRTST 307
           LY +K  GRNR S+
Sbjct: 457 LYEAKAAGRNRVSS 470


>UniRef50_C6CDM3 Diguanylate cyclase n=1 Tax=Dickeya dadantii Ech703
           RepID=C6CDM3_DICDC
          Length = 469

 Score =  282 bits (721), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 109/311 (35%), Positives = 178/311 (57%), Gaps = 6/311 (1%)

Query: 2   LADWFSEQFSTGVLIVPCMLTL--AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSL 59
             +WFS+QF T VL +P +LT+   I   +P      ++P + L  S+I   +I     L
Sbjct: 158 FLNWFSDQFYTSVLFLPLLLTVRSNIRLRIPALNFNDILPILFLAASLIVGAMISPLAIL 217

Query: 60  AFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSI-PQMFSARLGI 118
           AFPLPAL WCA+ Y   +T L+T  TG +++++ A  V  I  G       Q+   R+ I
Sbjct: 218 AFPLPALTWCAIVYPLWLTRLITLCTGTLQLIVSAEHVYAIYSGLHDEFTNQVVITRISI 277

Query: 119 ATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQT-QHLTV 177
           A +   P+ ++ +   I  L K++ L+A +DFLT   SR G  EAL +   ++  ++++V
Sbjct: 278 AAIIFSPLFMAMNAKTIRLLNKRLLLQASYDFLTNTLSRYGFNEALTNYGKEERYRNVSV 337

Query: 178 --MLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNP 235
             ML+DID+FK IND++GH+CGD+VL   A  I+  + ++GL++R+GGEEFAV     +P
Sbjct: 338 NIMLIDIDHFKHINDSFGHDCGDEVLKQVAAIIKDTINEQGLISRIGGEEFAVVCFDYSP 397

Query: 236 VDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLY 295
                +A+K+R+ +    F + Q  + + +SIG+    +    L +  ++L  +AD  LY
Sbjct: 398 DAFYWLADKLRRRIYETTFMFNQSPVPVAISIGLAHASSPNGDLLNTVHQLCTQADKNLY 457

Query: 296 RSKKDGRNRTS 306
            +K+ GRN+T 
Sbjct: 458 AAKRQGRNQTV 468


>UniRef50_A0P392 GGDEF domain protein n=1 Tax=Labrenzia aggregata IAM 12614
           RepID=A0P392_9RHOB
          Length = 307

 Score =  276 bits (707), Expect = 7e-73,   Method: Composition-based stats.
 Identities = 100/310 (32%), Positives = 157/310 (50%), Gaps = 13/310 (4%)

Query: 10  FSTGVLIVPCMLTLA--------IPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAF 61
               +  +P +L+           P  + +F  E+  P I L+VS IA  ++GG G++AF
Sbjct: 1   MVNYISFLPVVLSAPKLDGTHTDFPARIRQFWQEKWAPLILLLVSCIAGTLVGGPGAIAF 60

Query: 62  PLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATM 121
           P+PAL+WC + Y    T +LT   G   +V+++N  +  S      +  + S RLGI+ +
Sbjct: 61  PVPALLWCGLVYPVFPTTILTLCIGVWGLVILSNG-LGDSASLQLDVMTLVSIRLGISLV 119

Query: 122 AICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLD 181
           A+ PIM+S      N+L+ ++   A  D LT V +R+   E         T    ++++D
Sbjct: 120 ALAPIMLSCVTQNRNALVGRLQYLATHDQLTNVLNRNAFREEAARRLALGTSGFALLMVD 179

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           +D FK++ND +GH  GD VL  F   ++  +    L+ RMGGEEFAV +P    VD +  
Sbjct: 180 LDDFKAVNDTHGHATGDTVLVNFVHRVKNTLPPGSLLGRMGGEEFAVLIPDCRQVDAVAE 239

Query: 242 AEKIRKGVELQPFTW-QQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           AE IR+ V  +P      K + +T S+GV +         D  + L+ EAD   Y +KK 
Sbjct: 240 AENIRQSVGTEPVPAGDGKEVRVTASLGVVAVEHG---DADSLDTLLAEADRLCYLAKKR 296

Query: 301 GRNRTSTMRY 310
           GRNR   +  
Sbjct: 297 GRNRVEAIEE 306


>UniRef50_C8QCH2 Diguanylate cyclase n=1 Tax=Pantoea sp. At-9b RepID=C8QCH2_9ENTR
          Length = 474

 Score =  276 bits (706), Expect = 7e-73,   Method: Composition-based stats.
 Identities = 133/317 (41%), Positives = 197/317 (62%), Gaps = 4/317 (1%)

Query: 3   ADWFSEQFSTGVLIVPCMLTLAIPGVLPR--FKAEQMMPAIALIVSVIASVVIGGAGSLA 60
            DWFSEQFST ++++P +L   +  VL R      +++P   +++S+    +IGGAGSL 
Sbjct: 154 GDWFSEQFSTSLMLLPVLLARPLRTVLWRSLLHPGKLLPLTGVVLSLTIGAMIGGAGSLT 213

Query: 61  FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDIS-VGSPFSIPQMFSARLGIA 119
           FP+PALIWCA+     +T L+  +TG  EI+LV++ V++I    +   I  + S RLG+A
Sbjct: 214 FPVPALIWCAIVLPIPITSLVLLITGITEIILVSHGVMNIQGDDALLPISHLTSVRLGVA 273

Query: 120 TMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVML 179
           T+ I P++V+ S+ AI  L ++++LRA+FDFLTQ+ SRSGLYE L+       +   V++
Sbjct: 274 TITISPLLVAVSMDAIRQLNQRLSLRANFDFLTQLLSRSGLYENLRQEPFSPQRAAGVVM 333

Query: 180 LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGL 239
           LD+DYFK+INDN+GH+ GD VL   AR IQ +V ++GLV R GGEEF V V   N     
Sbjct: 334 LDVDYFKTINDNFGHDAGDGVLEEIARRIQDVVNNRGLVCRFGGEEFVVVVFDYNHSQLY 393

Query: 240 LMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRA-SYLTLTDDFNKLMVEADTCLYRSK 298
            +AE IR+ +  + F  Q  T+ +T S+G+  G A +        N+L+  AD  LY SK
Sbjct: 394 QLAEVIRQSMVREKFWLQGNTVTVTASLGLALGNAVNEREWQGVVNRLISAADKNLYLSK 453

Query: 299 KDGRNRTSTMRYGEEVV 315
           ++GRN+TS       +V
Sbjct: 454 RNGRNQTSPAVEPRPLV 470


>UniRef50_B5JW02 Diguanylate cyclase n=1 Tax=gamma proteobacterium HTCC5015
           RepID=B5JW02_9GAMM
          Length = 595

 Score =  274 bits (701), Expect = 3e-72,   Method: Composition-based stats.
 Identities = 69/319 (21%), Positives = 121/319 (37%), Gaps = 16/319 (5%)

Query: 2   LADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPA--------IALIVSVIASVVI 53
           +  W +       L +P    + +  +         + A          +    + S  +
Sbjct: 271 IILWAASGLVVASLFLPYFYVIRVLIICTILACVMGLFAGFYRQVEGYGVARFYLYSWSL 330

Query: 54  GGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFS 113
              G++   L            + + L     G V +       ++      +   Q  +
Sbjct: 331 FMLGAILVALNKFDVLPSNMITEYSMLFGTGVGTVVLSAALAVRLNDEKNKRYH-AQAEA 389

Query: 114 ARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ 173
            R+   ++ +    V    +A+    +++   ++ D LT + +R  L E L     +  +
Sbjct: 390 LRVQRESVELLEERVKERTSALREANEKLEKLSNTDSLTGLNNRRSLDELLAMEVKRTCR 449

Query: 174 ---HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIV-GDKGLVARMGGEEFAVA 229
               L+ M++DID FK+ ND +GH+ GD  L   A  I         +V R GGEEF V 
Sbjct: 450 TGAPLSAMMMDIDRFKAFNDTHGHQVGDACLKAVAGVIASTAQRPSDVVGRYGGEEFCVL 509

Query: 230 VPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVE 289
           +P        ++AE+IR  VE   FT   + + +T+SIGV          +D    L+  
Sbjct: 510 LPDTPLDGAQIIAERIRAAVENLDFTVSGQRVPVTISIGVSELTYC---ASDSGKALVEA 566

Query: 290 ADTCLYRSKKDGRNRTSTM 308
           AD  LY +K  GRN     
Sbjct: 567 ADEALYSAKSAGRNCVRLA 585


>UniRef50_A8GAZ5 Diguanylate cyclase n=2 Tax=Serratia RepID=A8GAZ5_SERP5
          Length = 482

 Score =  273 bits (699), Expect = 6e-72,   Method: Composition-based stats.
 Identities = 115/314 (36%), Positives = 181/314 (57%), Gaps = 13/314 (4%)

Query: 5   WFSEQFSTGVLIVPCMLTLAIPGVLPR----FKAEQMMPAIALIVSVIASVVIGGAGSLA 60
           WFSEQFST +L++P +L       L R    ++    MP +AL+ S++ SV IGG G++A
Sbjct: 158 WFSEQFSTNLLLLPVLLAAPRLKQLLRMQINWQLRASMPLLALLFSLVFSVYIGGPGAIA 217

Query: 61  FPLPALIWCAVRYTPQVTCLLTFVTGAVEIV-LVANSVIDISVGSPFSI-PQMFSARLGI 118
           FP+PAL+WCAVRY      LLT +TG  EI  + AN ++  +  +  +    + SARLGI
Sbjct: 218 FPIPALLWCAVRYQLFTVTLLTLLTGMTEISSISANLMLYETPNNHIAFLDTLMSARLGI 277

Query: 119 ATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEA---LKSPSLKQTQHL 175
           A + + P++++ S+A    L++++   A+ DFLT V +R+ L      L     K  + +
Sbjct: 278 AMLVMGPLILASSIAVNRKLLRRLEHSANHDFLTGVLARNALTRKAGELLEHKHKSKEAV 337

Query: 176 TVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNP 235
           +++L+DID+FK IND +GH  GD+VL+ FA  +++ +    L  R+GGEEFA+ +P    
Sbjct: 338 SLLLIDIDHFKQINDTHGHLVGDQVLASFAHIVRRELRHDQLFGRLGGEEFAIMLPRALA 397

Query: 236 VDGLLMAEKIRKGVELQP-FTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCL 294
             G+ +AE +R+ V+        +  L +T+S+GV S     +       +LM  AD  L
Sbjct: 398 AQGVALAEHLRQLVQKADLLPTGKVPLNITISVGVASL---GMNEVKSLEQLMNMADIAL 454

Query: 295 YRSKKDGRNRTSTM 308
           YR+K  GRNR  + 
Sbjct: 455 YRAKSQGRNRVESF 468


>UniRef50_A8V0B5 Diguanylate cyclase (GGDEF domain) n=1 Tax=Hydrogenivirga sp.
           128-5-R1-1 RepID=A8V0B5_9AQUI
          Length = 463

 Score =  269 bits (689), Expect = 9e-71,   Method: Composition-based stats.
 Identities = 66/233 (28%), Positives = 112/233 (48%), Gaps = 12/233 (5%)

Query: 79  CLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSL 138
            L+TF+        +   ++  S  + + I  + S    I    +  +++ FSV      
Sbjct: 239 YLITFIPVFNLNNHLMGYLVRYSKDNTYPI-ILKSFYTNITLSFLLAVILGFSVYIFLKD 297

Query: 139 MKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHE 195
           +++    ++ D LT +Y++    E L+     + +  + L++++ DID+FK IND YGH+
Sbjct: 298 LEKFRYLSETDRLTGLYNKGKFNEVLQREIQRAKRYKRPLSLIIFDIDHFKKINDTYGHK 357

Query: 196 CGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFT 255
            GD+VL   A+ I+K +      AR GGEEF +  P  N      +AEK+R+ VE   F 
Sbjct: 358 VGDEVLKALAKLIKKNIRKTDFAARWGGEEFVILAPETNVEGAKKLAEKLRQAVETYKFP 417

Query: 256 WQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
              K   +T+S+GV           +     +V AD  LY++K+ GRNR    
Sbjct: 418 TVGK---VTISLGVAQLEP-----DEKPEDFIVRADMALYKAKEGGRNRVEIA 462


>UniRef50_D0FTB2 Conserved uncharacterized protein YneF n=3 Tax=Erwinia
           RepID=D0FTB2_ERWPY
          Length = 464

 Score =  268 bits (686), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 120/312 (38%), Positives = 184/312 (58%), Gaps = 12/312 (3%)

Query: 3   ADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKA----EQMMPAIALIVSVIASVVIGGAGS 58
           + WFSEQ ST +L++P M++L     LP+  A      ++P + LIV++++++ +GG GS
Sbjct: 150 SSWFSEQMSTSILLLPLMISLPRRQQLPQLAAALRDSSVLPLLTLIVTIVSAIWLGGGGS 209

Query: 59  LAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDIS-VGSPFSIPQMFSARLG 117
           L FPLPAL+WCA+ Y   VTC LT +TG  EI+LVA +V++I   G  F I  + SARLG
Sbjct: 210 LLFPLPALLWCAISYPLFVTCFLTMLTGISEIILVAGNVLNIQGKGDLFRIDSLSSARLG 269

Query: 118 IATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH--- 174
           +A M I P++VS S  +   L+ ++  RAD+DFLT   +RSGL   L S    + +    
Sbjct: 270 VAAMLIGPLIVSLSTLSNKKLVARITRRADYDFLTGALTRSGLSTKLDSLVTGRNRQQGF 329

Query: 175 -LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSV 233
               +++DID FK IND +GH  GD VL+  A  +++ +    LV RMGGEEF + +  +
Sbjct: 330 IGAALVIDIDRFKDINDTWGHAAGDYVLAKTAECLREGLSPSTLVCRMGGEEFLILIQGM 389

Query: 234 NPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTC 293
                 L+A ++R+ VE     +    L +TVSIG+ S     ++  +  ++ ++ AD  
Sbjct: 390 TQPRSSLLANRLRQNVENNKIIFNGHDLSVTVSIGISSLN---ISNVNSLDESIMRADEQ 446

Query: 294 LYRSKKDGRNRT 305
           LY +K  GRN+ 
Sbjct: 447 LYIAKSSGRNQV 458


>UniRef50_C6CM30 Diguanylate cyclase n=1 Tax=Dickeya zeae Ech1591 RepID=C6CM30_DICZE
          Length = 470

 Score =  268 bits (685), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 120/310 (38%), Positives = 181/310 (58%), Gaps = 6/310 (1%)

Query: 2   LADWFSEQFSTGVLIVPCMLTLA--IPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSL 59
             +WFS+QF T VL +P +LTL   IP  LP  +    +P + L+VS++ + ++G    L
Sbjct: 159 FLNWFSDQFYTAVLFLPLLLTLRSQIPLQLPMLRLSDALPLLLLLVSIVVAPLLGPVAIL 218

Query: 60  AFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDIS-VGSPFSIPQMFSARLGI 118
           AFPLPAL WCA+ Y   +  L+T   GA E++L A  V        P+ + Q+  AR+GI
Sbjct: 219 AFPLPALTWCAIVYPLWLIRLITLCVGATELILTAEHVYAFYSPQDPYFMHQIIIARIGI 278

Query: 119 ATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHL 175
           A     P+M++ +   I  L  ++  +A  DFLT   SR G  EAL         Q   +
Sbjct: 279 AATIFSPLMMATNARTIRQLNARLLQQASHDFLTNTLSRYGFTEALTTHGQSVKSQHDAV 338

Query: 176 TVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNP 235
            +ML+DID+FK+IND++GH+CGD++L   A+ IQ+ V  +GLV+R+GGEEFAV   + NP
Sbjct: 339 NIMLIDIDHFKNINDSFGHDCGDEILRQVAKVIQQAVSAQGLVSRIGGEEFAVVCFNYNP 398

Query: 236 VDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLY 295
                +A+ +R+ ++   F + Q+ + +TVSIG+     S   L D  ++L   AD  LY
Sbjct: 399 SAFYRLADSLRQTIQQTVFLFNQQPVPVTVSIGIAHAPTSGKYLVDTVHELFPLADKNLY 458

Query: 296 RSKKDGRNRT 305
            +K++GRNRT
Sbjct: 459 TAKREGRNRT 468


>UniRef50_C6RK39 Diguanylate cyclase n=2 Tax=Acinetobacter radioresistens
           RepID=C6RK39_ACIRA
          Length = 445

 Score =  267 bits (684), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 89/319 (27%), Positives = 153/319 (47%), Gaps = 17/319 (5%)

Query: 1   MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQ--------MMPAIALIVSVIASVV 52
           +   WFS +    +LI+P +L L     + +             ++P   L+ S+  S  
Sbjct: 130 IFGYWFSAELQNAILILPLILNLPYQKGIHQIFRPADGPYSFLHILPIFVLLFSLSLSYY 189

Query: 53  IGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMF 112
             G G++ +P+ ALIWCA+ Y      L+T ++       +++  + +     +   +M 
Sbjct: 190 DSGPGAILYPIAALIWCALNYRHFTVALITSISCFYIAFFMSDKYLTLYPEQYYL--EMI 247

Query: 113 SARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYE---ALKSPSL 169
           S R GI TMAI P+ VS      + L++++      D LT   +R         L     
Sbjct: 248 SLRFGIITMAIAPLTVSSINRIRSQLIRELQHHVAHDELTASLTRRQFMRSAHLLLRQRT 307

Query: 170 KQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVA 229
           +++Q L V++LDID+FK IND YGH+ GD+ L   A  I++ +    L  R+GGEEFA+ 
Sbjct: 308 QESQSLAVLMLDIDHFKLINDKYGHQAGDEALRACAAVIRRSLRGYDLFGRLGGEEFAIV 367

Query: 230 VPSVNPVDGLLMAEKIRKGVELQPFTWQQKT-LYLTVSIGVGSGRASYLTLTDDFNKLMV 288
           +  V P +   +AE+IR+ ++        +T   + +SIG+     +      +   L+ 
Sbjct: 368 LLDVGPAEAFEIAERIRETLKTHIIQLDAETQFSIRISIGLTLFNPAVPH---NIEALLH 424

Query: 289 EADTCLYRSKKDGRNRTST 307
           +AD  LY +K+ GR+R   
Sbjct: 425 KADLALYEAKRSGRDRVVI 443


>UniRef50_D0S942 Response regulator n=2 Tax=Acinetobacter RepID=D0S942_ACIJO
          Length = 476

 Score =  267 bits (684), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 83/318 (26%), Positives = 150/318 (47%), Gaps = 15/318 (4%)

Query: 2   LADWFSEQFSTGVLIVPCMLTLAIPGVLPRFK---------AEQMMPAIALIVSVIASVV 52
              W++ +    + ++P MLT      L                ++P +++++SV  + +
Sbjct: 164 FYIWWTGEVLNCISLLPLMLTFPAAKKLKYLWNNRRQCETQFVDVLPLLSVLISVACTHL 223

Query: 53  IGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMF 112
             G G+L FPL  LIW A+ Y      ++  +   V     + +   IS  +   +    
Sbjct: 224 FFGPGALLFPLAGLIWAALSYNLFYVSIINSLVCFVTYH--SLTTYYISRTADNFLATSI 281

Query: 113 SARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQ- 171
           S R+G+  + I P+++       + L K+V   A+ D LT V +R   +   ++   +  
Sbjct: 282 SVRIGLCMLMIAPLLLCIVSRNRHDLYKEVLYLANHDPLTHVGNRRFFFTQTENLLKENL 341

Query: 172 TQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVP 231
            + +++++LDID+FK +ND YGH  GD +L  FA  ++  + ++ L ARMGGEEF V + 
Sbjct: 342 VKSMSIIVLDIDHFKKMNDQYGHYIGDVLLQSFATTVKSNLREQDLFARMGGEEFVVVLN 401

Query: 232 SVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEAD 291
           +   ++  ++AE+I + V           L +TVS+GV       L   +    L+  AD
Sbjct: 402 NTTEIESQIIAERICRAVATSKTQVAHAVLSMTVSLGVVH---QVLPTQNSLQSLLNRAD 458

Query: 292 TCLYRSKKDGRNRTSTMR 309
             LY++K  GRN+     
Sbjct: 459 RALYQAKTLGRNQVQLAS 476


>UniRef50_D2C311 Diguanylate cyclase n=1 Tax=Dickeya dadantii Ech586
           RepID=D2C311_DICD5
          Length = 471

 Score =  265 bits (678), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 113/311 (36%), Positives = 177/311 (56%), Gaps = 7/311 (2%)

Query: 2   LADWFSEQFSTGVLIVPCMLTLAIPGVLP---RFKAEQMMPAIALIVSVIASVVIGGAGS 58
             +WFS+QF T VL +P +LTL     L      +    +P + L++S+  + ++G    
Sbjct: 159 FLNWFSDQFYTAVLFLPLLLTLQSRIPLHLPASLQMADALPLLLLLLSICIAPLLGPVAI 218

Query: 59  LAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDIS-VGSPFSIPQMFSARLG 117
           LAFPLPAL WCA+ Y   +  L+T   GA E+++ A  V  +     P  + Q+  AR+G
Sbjct: 219 LAFPLPALTWCAIVYPLWLIRLITLCVGATELIMTAEHVYALYNPQDPMFLHQVVIARIG 278

Query: 118 IATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEAL---KSPSLKQTQH 174
           IA     P+M++ +   I  L  ++  +A  DFLT   SR G  EAL         Q   
Sbjct: 279 IAATIFSPLMMATNARTIRQLNARLLRQASHDFLTNTLSRYGFTEALSTHDQNIKSQQDA 338

Query: 175 LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVN 234
           + +ML+DID FK+IND++GH+CGD++L   A  IQ+ V  +GLV+R+GGEEFAV   + +
Sbjct: 339 VNIMLIDIDNFKNINDSFGHDCGDEILRQVANVIQRTVSAQGLVSRIGGEEFAVVCFNYS 398

Query: 235 PVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCL 294
           P     +A+++R+ ++   F + Q+ + +TVSIG+   + +   L D  ++L   AD  L
Sbjct: 399 PPAFYRLADELRQTIQHTVFLFNQQHVPVTVSIGIAHAQVAGKHLVDTVHELFPLADKNL 458

Query: 295 YRSKKDGRNRT 305
           Y +K++GRNRT
Sbjct: 459 YTAKREGRNRT 469


>UniRef50_C6DKF8 Diguanylate cyclase n=5 Tax=Pectobacterium RepID=C6DKF8_PECCP
          Length = 489

 Score =  265 bits (677), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 90/320 (28%), Positives = 145/320 (45%), Gaps = 17/320 (5%)

Query: 2   LADWFSEQFSTGVLIVPCML-------TLAIPGVLPRFKAEQMMPAIALIVSVIASVVIG 54
             DWFSEQ  TG+++    L        L    + P+   E + P +  I+ ++ S+   
Sbjct: 167 FMDWFSEQLGTGIILAFFFLRGKDILRALRNIPLCPKHIRENIFPFLVFIIFLLVSLFFQ 226

Query: 55  GAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVAN--SVIDISVGSPFSIPQMF 112
            A  +   +  L  CA  Y+  +  LL  +TG +   L  N   ++  S    +    + 
Sbjct: 227 DASLITLSVIPLTLCAFNYSFPIMSLLCAITGVILNYLYINQVGILINSNSEAYINSFLT 286

Query: 113 SARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP----S 168
           +ARL IA + +  + VS  V+    L+K +   +  D LT  ++R      L        
Sbjct: 287 TARLNIAMLIMAMLSVSHFVSMNRRLIKIIESNSLKDALTNTFNRRAFLSMLNGRQGLLM 346

Query: 169 LKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAV 228
            K+ + LT++ LDIDYFK +ND YGH  GD++++ FAR +   +    ++ R GGEEF +
Sbjct: 347 NKRKRQLTLLFLDIDYFKQVNDTYGHASGDELIASFARMLSANIRPSDILCRWGGEEFVI 406

Query: 229 AVPSVNPVDGLLMAEKIRKGVELQPFTW-QQKTLYLTVSIGVGSGRASYLTLTDDFNKLM 287
           A   +       MAE +R   E  P      + +  T+SIGV +          +   L+
Sbjct: 407 AAYDLTAEQSAAMAETLRHLTESTPLVLSDGREIRFTISIGVVTFP---QYEGGNTYDLI 463

Query: 288 VEADTCLYRSKKDGRNRTST 307
             AD  LY++K  GRNR   
Sbjct: 464 GLADEQLYKAKAQGRNRVCL 483


>UniRef50_B7GZC2 Uncharacterized protein yneF n=10 Tax=Acinetobacter
           RepID=B7GZC2_ACIB3
          Length = 473

 Score =  265 bits (677), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 94/316 (29%), Positives = 148/316 (46%), Gaps = 17/316 (5%)

Query: 2   LADWFSEQFSTGVLIV--------PCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVI 53
              W + +    +L++           +   + G     KA   +P  A+++S+  S   
Sbjct: 159 FGYWVTSELQNALLLLPIILNIPPYLKIKTHLKGNRIYIKAIDFLPLFAVLISIGVSYYD 218

Query: 54  GGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFS 113
            G GSL +P+ ALIWCA+RY P +  L+T  T A  I  V+   + +      S     S
Sbjct: 219 SGPGSLLYPIAALIWCAIRYKPIIVALITSFTSAYIIYHVSGHYLLLYPQDYLSNN--IS 276

Query: 114 ARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYE---ALKSPSLK 170
            R+G+  M + P+ VS   A  + L++++      D LT   +R    +    L+    K
Sbjct: 277 IRIGLIMMTVAPLTVSSISALHSELIQKLQHAIAHDELTSSLTRRQFLQSVRLLQEKVQK 336

Query: 171 QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAV 230
           + +     +LD+D+FK +ND+YGH  GD+ L      IQ I+    L+ R GGEEFA+ +
Sbjct: 337 ENKTSAFFMLDVDHFKKVNDSYGHLIGDRALQTCVTTIQNILHPHDLLGRFGGEEFAIFI 396

Query: 231 PSVNPVDGLLMAEKIRKGVELQPFTWQQK-TLYLTVSIGVGSGRASYLTLTDDFNKLMVE 289
           P         +AE+IR  +  QP     K  +++ VSIG+     SY         L  E
Sbjct: 397 PDTTREAAFELAERIRIQISQQPIYVYGKLPIFVQVSIGISLYSPSYHR---SIESLFKE 453

Query: 290 ADTCLYRSKKDGRNRT 305
           AD  LY++K+ GRNR 
Sbjct: 454 ADDALYQAKRQGRNRV 469


>UniRef50_B8FCK6 Response regulator receiver modulated diguanylate cyclase n=1
           Tax=Desulfatibacillum alkenivorans AK-01
           RepID=B8FCK6_DESAA
          Length = 301

 Score =  264 bits (675), Expect = 3e-69,   Method: Composition-based stats.
 Identities = 73/292 (25%), Positives = 130/292 (44%), Gaps = 13/292 (4%)

Query: 20  MLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTC 79
           MLT     V      E+ + A+A I   +  + +   G   + +   I  +         
Sbjct: 20  MLTARGHEVTVATNGEEGLEAVATIKPDLILLDLIMPGMDGYAVCEKIKGSPATADIPVI 79

Query: 80  LLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLM 139
           +LT      + V    +     V  PF   ++ +            + +     ++    
Sbjct: 80  MLTSKAETADKVRGLEAGASDYVTKPFEEGELVAR-------VNTHLRIKELYESLQETN 132

Query: 140 KQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKSINDNYGHEC 196
           +Q+   A+ D LT +Y+     +A+      +++  + L+ +L DID+FK  ND YGH+ 
Sbjct: 133 RQLQELANRDGLTGLYNHRYFQDAMTKDFQRAMRYHESLSCVLCDIDFFKKFNDTYGHQT 192

Query: 197 GDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTW 256
           GD VLS  AR ++  + D  L AR GGEEFA+ +         ++AE++R+ VE   F  
Sbjct: 193 GDIVLSTLARIVEDSLRDTDLAARYGGEEFALVLYHTPAAAAFMVAERLRESVEQHEFIA 252

Query: 257 QQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
              +L +T+S+GV +     +    D   L+  AD  LY++K++GRN+  + 
Sbjct: 253 NDLSLSVTISVGVATYPHPDIP---DHKTLIECADKALYKAKENGRNQVISF 301


>UniRef50_Q4KDW8 GGDEF domain protein n=6 Tax=Pseudomonas RepID=Q4KDW8_PSEF5
          Length = 315

 Score =  263 bits (672), Expect = 8e-69,   Method: Composition-based stats.
 Identities = 59/183 (32%), Positives = 95/183 (51%), Gaps = 4/183 (2%)

Query: 128 VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKS 187
           V+ +  A+    +Q+   +  D LTQ+Y+R    + L+    +    + +++LDID+FKS
Sbjct: 137 VAINSLALQKANQQLQHLSRTDHLTQLYNRGHWEQRLQFEYSRHGSSIALLMLDIDHFKS 196

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           IND +GH+ GD V+   +  I + V D  +  R GGEEFA+ +P  +      +AE++R+
Sbjct: 197 INDRHGHQAGDAVIKRVSELIHQHVRDSDVAGRYGGEEFAILLPHTDLAGARTLAERLRQ 256

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
            VE Q      + +  T+S+G+            D   L+  AD  LY SK+ GRNR ST
Sbjct: 257 SVEEQEVIHNGQAIAFTISLGIACLD----RPARDHRCLIEWADQALYASKRAGRNRVST 312

Query: 308 MRY 310
              
Sbjct: 313 YAP 315


>UniRef50_B8DLP9 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfovibrio
           vulgaris str. 'Miyazaki F' RepID=B8DLP9_DESVM
          Length = 730

 Score =  262 bits (671), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 61/189 (32%), Positives = 92/189 (48%), Gaps = 8/189 (4%)

Query: 123 ICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVML 179
           I    +           +++   A  D LT + +R    EAL+    +  +    L ++ 
Sbjct: 527 IVYCGIITDTTEHREAQERLRQLATTDGLTGLANRRRFLEALEHEVQRHRRYGTPLALIS 586

Query: 180 LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGL 239
           +D+D FK +ND +GH  GD+VL   A   +  V D   V R+GGEEFAV +P   P + +
Sbjct: 587 IDVDRFKRVNDTWGHAVGDEVLRALAGICRAEVRDVDTVGRIGGEEFAVLLPDTAPEEAM 646

Query: 240 LMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKK 299
            +AE++R GVE  P       L +T+S+GV +         D  + L+ EAD  LYR+K 
Sbjct: 647 AVAERLRAGVEAAPLLTTAGPLTVTLSLGVSASPPC-----DGADTLLREADRALYRAKA 701

Query: 300 DGRNRTSTM 308
            GRNR    
Sbjct: 702 GGRNRVERA 710


>UniRef50_C6WYA7 Diguanylate cyclase with PAS/PAC and GAF sensors n=1
           Tax=Methylotenera mobilis JLW8 RepID=C6WYA7_METML
          Length = 591

 Score =  261 bits (667), Expect = 3e-68,   Method: Composition-based stats.
 Identities = 59/190 (31%), Positives = 97/190 (51%), Gaps = 8/190 (4%)

Query: 123 ICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVML 179
           +  I  S  +     L +++  +A  DFLT V +R    E  +    + ++    L+  +
Sbjct: 404 LRMIGTSTDITERKQLEEELKRQARIDFLTGVSNRRYFMEQAEQEIQRTSRYDTPLSFFM 463

Query: 180 LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGL 239
           LDID FK +ND YGH+ GD VL   A   ++ + +  ++ R+GGEEFA+ +P  +     
Sbjct: 464 LDIDLFKQVNDTYGHKSGDIVLKRMASVCRETLREIDIIGRVGGEEFAILLPETDKAQAA 523

Query: 240 LMAEKIRKGVELQPFTWQ-QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSK 298
            +AE++R  +  +    +    +  TVSIGV S  +S     D+ + L+  AD  LY++K
Sbjct: 524 EVAERLRSVLADEKVPTEAGAPIQFTVSIGVASRVSSQ----DNIDMLLNLADEALYQAK 579

Query: 299 KDGRNRTSTM 308
           K GRNR    
Sbjct: 580 KYGRNRVYIA 589


>UniRef50_B4U6Y8 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Hydrogenobaculum
           sp. Y04AAS1 RepID=B4U6Y8_HYDS0
          Length = 772

 Score =  260 bits (666), Expect = 4e-68,   Method: Composition-based stats.
 Identities = 55/187 (29%), Positives = 90/187 (48%), Gaps = 11/187 (5%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLL 180
             +     +     L   +  ++  D LT +Y+R  L   L+     + +  + L++++ 
Sbjct: 593 VAVFTFVDITKEKELSDMLLKQSTEDPLTGIYNRRYLENKLEEYVKLAKRHDRPLSLIMF 652

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DID+FK IND++GH+ GDKVL   A+ + + + +  + AR GGEEF +  P     D  +
Sbjct: 653 DIDFFKHINDSFGHDVGDKVLKAIAKVVSENIRNTDIFARYGGEEFVIIAPETTKEDAKI 712

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           +AEK+R  +    F      + +T S GV S         D    L+  AD  LY +KK 
Sbjct: 713 LAEKLRSLIRNLHFEEG---INVTCSFGVASLEKH-----DTKETLLKRADEALYEAKKT 764

Query: 301 GRNRTST 307
           GRN+   
Sbjct: 765 GRNKVVV 771


>UniRef50_C1SIQ7 Diguanylate cyclase (GGDEF) domain-containing protein n=1
           Tax=Denitrovibrio acetiphilus DSM 12809
           RepID=C1SIQ7_9BACT
          Length = 312

 Score =  260 bits (666), Expect = 4e-68,   Method: Composition-based stats.
 Identities = 61/292 (20%), Positives = 120/292 (41%), Gaps = 15/292 (5%)

Query: 18  PCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQV 77
           P  L  A+ G        + +P + L+        +       F +   +          
Sbjct: 30  PYGLAFAMSGKEALEYLVKNVPDMVLL-------DVMMPDMDGFEVCKTLHARAETKGIP 82

Query: 78  TCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINS 137
              +T  +   +IV          V  PF+  ++         +     ++      +  
Sbjct: 83  VIFITAKSEPEDIVKGFQMGGVDYVTKPFNEAELLMRINTHMELKRARDLLEEKNKELIE 142

Query: 138 LMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGH 194
              ++   A  D LT + +R  +   L   + +  ++    ++++ DID+FK +ND YGH
Sbjct: 143 AYDKIEHLALTDTLTGIANRRNITNMLGKEAARCKRNKGKFSLIMCDIDFFKRVNDTYGH 202

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
           + GD VL   +  IQ+ + ++ +VAR GGEEF + +P  +  + + +AEK+R  +     
Sbjct: 203 DAGDYVLKTISHVIQQALREQDIVARWGGEEFLIVLPETDAGNAVAVAEKLRTAIGNTEM 262

Query: 255 TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
           +++  +  +T++ GV     S         K + +AD  LY  K+ GRN+  
Sbjct: 263 SYEGISFSVTMTFGVSEYDVSL-----GIEKSIKKADDALYEGKQTGRNKVV 309


>UniRef50_B5JX81 Diguanylate cyclase n=1 Tax=gamma proteobacterium HTCC5015
           RepID=B5JX81_9GAMM
          Length = 384

 Score =  260 bits (665), Expect = 5e-68,   Method: Composition-based stats.
 Identities = 81/335 (24%), Positives = 140/335 (41%), Gaps = 34/335 (10%)

Query: 1   MLADWFSEQFSTGVLIVPCMLTLAI---------------PGVLPRFKAEQMMPAIALIV 45
           ML +  + + +   +IV  +L                      L      Q   A+ +++
Sbjct: 53  MLGNGLNNEVANTAIIVILVLAACCGIGFILGFKADATAWTSKLYAHICIQFFVAVNMVL 112

Query: 46  SVIASVV--IGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISV- 102
           +  A V   + G   +   L   I    R            T A+ I+     +   SV 
Sbjct: 113 AYYAGVFSVVSGVALVGGSLTGFILFNERVVYGGLFTGALATLALIILSALEVIPYASVI 172

Query: 103 ---GSPFSIPQMFSARLGIATMAICPIMVSF---SVAAINSLMKQVALRADFDFLTQVYS 156
              G+P      +   L   +     ++V+    ++        +V   +  D LTQV +
Sbjct: 173 ETNGTPLHHNATWLILLLGLSTPYIGLLVAMNSSAIRRWRQRESEVRQLSTTDPLTQVAN 232

Query: 157 RSGLYEALKSPSLKQTQH----LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIV 212
           R  L E L     +  +     L+++++D+D+FKSIND +GH  GD+ L V AR +++  
Sbjct: 233 RRHLLERLNLEISRCERSGHSELSLLMMDLDHFKSINDEHGHLFGDEALRVTARVLREQS 292

Query: 213 GDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKT-LYLTVSIGVGS 271
            +  LV R GGEEF + +P   P   L +AE+ R+ +E      +    L++T SIG+ +
Sbjct: 293 RNTDLVGRYGGEEFCLLLPDTGPQGALQIAERCRQALEQADIDREDGEVLHITTSIGLAT 352

Query: 272 GRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
            +     + D    L+  AD  LY++K+ GRNR  
Sbjct: 353 YQ-----MGDTNESLLHRADEALYQAKEQGRNRIV 382


>UniRef50_Q30QX5 Diguanylate cyclase n=2 Tax=Proteobacteria RepID=Q30QX5_SULDN
          Length = 564

 Score =  259 bits (663), Expect = 9e-68,   Method: Composition-based stats.
 Identities = 77/326 (23%), Positives = 133/326 (40%), Gaps = 29/326 (8%)

Query: 10  FSTGVLIVPCMLTLAIPGVLPR-------FKAEQMMPAIALIVSVIASVVIGGAG----- 57
           F+ G+++ P  L L I  +           K    +  ++L   +   +    A      
Sbjct: 240 FNFGMMLSPIFLALFIQTIFKTKEQYINEHKLLNSIIFVSLANFIYGLIDFNSALEIMSS 299

Query: 58  SLAFPLPALIWCAVRY-----TPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMF 112
           SL + L   +W ++R            L+      +  V      + I+  +  S     
Sbjct: 300 SLTYALIVFMWISIRICKKGDKLIKIFLIAHTLYLIFSVYALLYYLGIADANYISSHGTS 359

Query: 113 SARLGIATMAICPIMVSFSVAAINSLMKQ-----VALRADFDFLTQVYSRSGLYE---AL 164
              +  A +    +   F +       ++     + L A  D +T++Y+R    E    +
Sbjct: 360 IGLIIEAMLLSYLVSYKFIIMEQEKEEEKLKQIELKLLASTDSMTKLYNRRYFTEISAKV 419

Query: 165 KSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGE 224
              S ++  +L+++++DID FK +ND YGH+ GD+VL   +R + +      +V R GGE
Sbjct: 420 LHLSKREKNNLSILMIDIDRFKVVNDTYGHQFGDEVLIALSRLLVEHQRKSDIVCRYGGE 479

Query: 225 EFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ-QKTLYLTVSIGVGSGRASYLTLTDDF 283
           EF + +P+ +  D   +A+KIR  VE         K    T+SIGV       +   DD 
Sbjct: 480 EFVILLPNTSLKDATNIAQKIRILVESLTMEAPTNKEFKFTISIGVAQID---VEHEDDI 536

Query: 284 NKLMVEADTCLYRSKKDGRNRTSTMR 309
              +  AD  LYR+K  GRNR     
Sbjct: 537 KFALKRADDALYRAKNSGRNRVCAEE 562


>UniRef50_Q39ZK6 Response regulator receiver modulated diguanylate cyclase n=8
           Tax=Geobacter RepID=Q39ZK6_GEOMG
          Length = 314

 Score =  258 bits (661), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 64/264 (24%), Positives = 116/264 (43%), Gaps = 13/264 (4%)

Query: 48  IASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFS 107
           +    +       F    ++     +      +LT        +          V  PF 
Sbjct: 51  LVLCDLEMPRMDGFRFLTMMRAREEFQDLPVIILTGREDRDTKIRGLEQGASDFVTKPFD 110

Query: 108 IPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP 167
             ++ +            + +      +    + +   +  D LT +++R  L E +   
Sbjct: 111 TGELVAR-------VRVQLKMKGLQDELKRSNEMLRTLSITDPLTHLHNRRHLMEMVDKE 163

Query: 168 SLKQTQ---HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGE 224
             + ++    L++++LDIDYFK IND YGH+ GD+VL++ A  +++ +    L AR GGE
Sbjct: 164 FQRSSRKGAPLSLVILDIDYFKKINDTYGHQEGDRVLTILADIVRRRLRSYDLAARYGGE 223

Query: 225 EFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFN 284
           EF + +P     + L +AE++R  V+   F      L +T+S+GV +  +S     +  +
Sbjct: 224 EFVLLLPETPVQEALSIAERLRLEVQEHVFEGSLGGLVITISLGVATYPSS---RVESID 280

Query: 285 KLMVEADTCLYRSKKDGRNRTSTM 308
            L  +AD  LYR+K+ GRNR   M
Sbjct: 281 SLFRQADEALYRAKQGGRNRVELM 304


>UniRef50_D1U434 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfovibrio
            aespoeensis Aspo-2 RepID=D1U434_9DELT
          Length = 1051

 Score =  258 bits (660), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 50/186 (26%), Positives = 93/186 (50%), Gaps = 7/186 (3%)

Query: 125  PIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLD 181
             +     +    +   ++   A  D LT +++R    E  +   ++  ++   LT++++D
Sbjct: 869  AVATIRDITERKATEARLHELATTDSLTGLFNRRRFMELAEREFMRTKRYQGALTMLMMD 928

Query: 182  IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
            ID+FK +ND +GH  GD+VL   AR  +  + +  ++ R+GGEEF V +P  +    + +
Sbjct: 929  IDHFKRVNDTHGHGVGDEVLRELARISRTALRELDILGRLGGEEFGVLLPETDAGPAMEV 988

Query: 242  AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
            A+++R+ +E         TL +TVSIG  +         +    L+  AD  LY +K+ G
Sbjct: 989  AQRLRRAIEKASMATDAGTLRITVSIGAATSN----NDAETVETLLKRADVALYEAKQSG 1044

Query: 302  RNRTST 307
            RN+   
Sbjct: 1045 RNKVVA 1050


>UniRef50_A9WGU1 Diguanylate cyclase n=3 Tax=Chloroflexus RepID=A9WGU1_CHLAA
          Length = 324

 Score =  258 bits (660), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 64/282 (22%), Positives = 117/282 (41%), Gaps = 7/282 (2%)

Query: 28  VLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGA 87
           V P  +    + AI  I   +  + I       + +   +             ++ +   
Sbjct: 45  VRPVTQGTAALTAIRTIRPDLVLLDIRMPDMDGYEVCQQLKADEETAQIPVIFISALDDV 104

Query: 88  VEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRAD 147
            + V          +  PF   ++ +       +A     +  +   +   + + A  A 
Sbjct: 105 EDKVRAFECGGVDYIAKPFQPLEVLARVRTHLALAQARKALEAANRELQRALAREAELAR 164

Query: 148 FDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVF 204
            D+LT VY+RS  YE  +     + +  + LT+ +LD+D+FK IND YGH  GD+VL   
Sbjct: 165 MDWLTGVYNRSHFYELARHEFAIATRYERPLTMCMLDVDHFKQINDRYGHLVGDQVLRAV 224

Query: 205 ARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLT 264
           A+ +   +     + R GGEEF + +P+ N    L +AE++R  +        +  +  T
Sbjct: 225 AQTVAHQIRTADSIGRFGGEEFILLLPNTNLPSALTLAERLRVTIADLQVHTDRGIVTAT 284

Query: 265 VSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
           +S+GV   ++          +L+  AD  LY +K+ GRN   
Sbjct: 285 ISVGVAERQS----TDTTIERLIDRADRALYAAKRQGRNCVV 322


>UniRef50_A9C2H0 Diguanylate cyclase n=2 Tax=cellular organisms RepID=A9C2H0_DELAS
          Length = 496

 Score =  257 bits (658), Expect = 3e-67,   Method: Composition-based stats.
 Identities = 94/325 (28%), Positives = 169/325 (52%), Gaps = 18/325 (5%)

Query: 1   MLADWFSEQFS--TGVLIVPCMLTLAIPGVLPRFKAEQ-----MMPAIALIVSVIASVVI 53
           M+A WFS +    T +L V   L   +  +  R +  +     ++P +AL +S   ++ +
Sbjct: 160 MMAMWFSSELMHMTLLLPVLLSLPAKLEPLSWRSQPFKQTAQALLPLLALAISESIAIYL 219

Query: 54  GGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFS 113
           GG G+L+  +PA++ CA+RY   V  LL  V+ A+++    + V+  S G+       FS
Sbjct: 220 GGPGALSLTMPAMLLCAMRYRLFVVALLNLVSCAIKL-ATFSHVLFSSPGTEL--ETTFS 276

Query: 114 ARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKS---PSLK 170
            RLG+A ++I P+ V+ ++ A   ++ ++    + D LT + +R+   E  +       +
Sbjct: 277 FRLGLAMLSIGPLAVACTLMAFKDMLSKLRHAVNHDALTGLLARTSFLERAQRTLERLQR 336

Query: 171 QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAV 230
           + Q   +++LD+D+FK IND +GH  GD+VL   +  + + +    L+ R+GGEEFAV +
Sbjct: 337 ERQSGAMLMLDLDHFKHINDRHGHAAGDRVLQEVSARLSQALRPHELIGRLGGEEFAVLL 396

Query: 231 PSVNPVDGLLMAEKIRKGVELQPFTWQQK-TLYLTVSIGVGSGRASYLTLTDDFNKLMVE 289
           P  + V    +A+++ +              +  T+SIG+G    +Y  L    + L+  
Sbjct: 397 PGADCVTARAVAQRLCEATREIRIDMNDGAAICPTLSIGIGCTNMAYPPLG--LSALLRM 454

Query: 290 ADTCLYRSKKDGRNR--TSTMRYGE 312
           ADT LY++K  GR+R   +  R GE
Sbjct: 455 ADTALYQAKASGRDRYFVAGERPGE 479


>UniRef50_A8FZ07 Diguanylate cyclase n=2 Tax=Shewanella RepID=A8FZ07_SHESH
          Length = 298

 Score =  257 bits (658), Expect = 3e-67,   Method: Composition-based stats.
 Identities = 79/284 (27%), Positives = 136/284 (47%), Gaps = 19/284 (6%)

Query: 43  LIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISV 102
           ++  + + +VI GA  LA  +   +W  VR  P      ++    + I++     +  + 
Sbjct: 4   ILPVLGSGLVISGALLLAMAIAP-VWKIVRQLPTGGLRYSWGFLILLILIFIAGYVIYAK 62

Query: 103 GSPFSIPQMFSARLGIATM---AICPIMVSFSVAAINSLMK--QVALRADFDFLTQVYSR 157
            SP    Q+F   + I          ++ S S+     +M+   +      D L  +++R
Sbjct: 63  FSPVQFSQLFDLVVPIIFFGGAIFVFVVCSLSLRTTRDIMQNYALKQENITDSLMGIFNR 122

Query: 158 SGLYEALKSPSLK---QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGD 214
             L   LK  + +    +Q L++ L+DID+FK +NDNYGH+ GD VL   A+ I+  + +
Sbjct: 123 RYLDRRLKDETERALNYSQPLSIFLIDIDHFKQVNDNYGHQVGDLVLKNIAQLIKHSLRE 182

Query: 215 KGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQK------TLYLTVSIG 268
             ++AR GGEEF V +P         +AE++R  VE    T  ++      ++ +TVSIG
Sbjct: 183 SDVLARFGGEEFVVILPRTKDSTSYTLAERLRHVVEDFQLTLPEESDKDSLSISVTVSIG 242

Query: 269 VGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGE 312
           V    A       D   L+  AD  LY++K++GRN+  T + G+
Sbjct: 243 VAGLNAQC----KDCQCLIENADRALYQAKRNGRNQVITSKSGK 282


>UniRef50_Q21HV6 Response regulator receiver modulated diguanylate cyclase n=2
           Tax=Alteromonadales RepID=Q21HV6_SACD2
          Length = 301

 Score =  257 bits (657), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 59/260 (22%), Positives = 108/260 (41%), Gaps = 13/260 (5%)

Query: 48  IASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFS 107
           +  + I   G        ++            +++  TG   I+   +      V  P  
Sbjct: 48  MILLDIRMPGLSGLETLEILKSDEATRMIPVIMVSATTGDQSIIRALDLGAHDFVSKPIE 107

Query: 108 IPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP 167
            P +       A      + +  +   +    K++   A  D LT + +R   ++  ++ 
Sbjct: 108 YPVL-------AARMRSALRLIQAKRDLEKANKELERLATRDPLTGINNRRSFFKLAEAE 160

Query: 168 SL---KQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGE 224
                +  + + +++LD D+FK IND YGH  GD+ L       Q    +  ++AR+GGE
Sbjct: 161 LTKTIRHGRDIALLMLDADHFKMINDTYGHAAGDEALLTITEICQNACRESDILARLGGE 220

Query: 225 EFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFN 284
           EFA+  P  N      +AE+IR+  E         +  +T+SIG+ +   S         
Sbjct: 221 EFAICCPDTNLEGAYAVAERIRQQCENTVIEHNSASFGITLSIGITTFVPSQ---DKSIT 277

Query: 285 KLMVEADTCLYRSKKDGRNR 304
           +++  AD  LY++K+ GRNR
Sbjct: 278 EMLQRADNLLYQAKEMGRNR 297


>UniRef50_C6NZP2 Periplasmic/7TM domain sensor diguanylate cyclase n=1
           Tax=Sideroxydans lithotrophicus ES-1 RepID=C6NZP2_9PROT
          Length = 570

 Score =  257 bits (657), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 71/314 (22%), Positives = 136/314 (43%), Gaps = 21/314 (6%)

Query: 11  STGVLIVPCMLTL------AIPGVLPRFKAEQMMPAIALIV-----SVIASVVIGGAGSL 59
             G++     L L       + G+        ++ A+AL+V     + + + V   A ++
Sbjct: 263 VLGLMFAARFLALKKHSPRTLRGIRWIGTLAVVIMALALMVDSQFVAAMVAFVCTTAFTI 322

Query: 60  AFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIA 119
              L  ++      T     L     G + + + A +V       P++        +  A
Sbjct: 323 GMFLLGILSVLRNQTSGRYFLFATFFGMLGVGVTALAVWGKIPFRPYTFHAAEFGLVIEA 382

Query: 120 TMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLT 176
           T+    + +S  +      + +    A  D LT + +R    E      S + +  + ++
Sbjct: 383 TL--LALGLSNWMRENRDALYEAEQVARLDALTHLNNRRAFMELALPYASTAGRHERPMS 440

Query: 177 VMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPV 236
           ++++DID+FKSIND YGH+ GD VL+  A  ++       +VAR GGEEF + +P     
Sbjct: 441 LVMMDIDHFKSINDQYGHQTGDLVLTAVADLLKNFSRTSDIVARWGGEEFILLLPETGLK 500

Query: 237 DGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYR 296
             +  AE++R+ +        + ++ LT S G+ +  A+       F+K++ +AD  LY 
Sbjct: 501 QAINHAERLRQAIAEFRIPVGETSISLTASFGIAAHVANL-----SFDKMIEQADVQLYE 555

Query: 297 SKKDGRNRTSTMRY 310
           +K+ GRN+      
Sbjct: 556 AKRSGRNKVCCSSA 569


>UniRef50_C1XLF8 Diguanylate cyclase (GGDEF) domain-containing protein n=1
           Tax=Meiothermus ruber DSM 1279 RepID=C1XLF8_MEIRU
          Length = 373

 Score =  256 bits (656), Expect = 5e-67,   Method: Composition-based stats.
 Identities = 70/315 (22%), Positives = 129/315 (40%), Gaps = 23/315 (7%)

Query: 15  LIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASV-VIGGAGSLAFPL-------PAL 66
           L++P  +             + +     + +++IA   ++      A+ L       PA 
Sbjct: 58  LLLPMAVGFIALEFHLWRNPQNVRWVWQIALALIAIYEIVSLFYEAAYKLHQRDGITPAA 117

Query: 67  IWCAVRYTPQVTCLL---TFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAI 123
           +W  + Y      L          V +VL   +     + SP       +  L      I
Sbjct: 118 LWFPMVYLMAFNLLNRRQALRFSLVYLVLGLLAGAVGMLMSPSINVSSINTALQFTFSNI 177

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLL 180
             + + +  A +     Q+   A  D LT + +R  + + L+     + +  +   ++L 
Sbjct: 178 AYLALLYMFAYLRRHYAQMHQMAHTDALTNLTNRRAMQQKLEGELDRARRYNRPFALLLA 237

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           D+D+FK IND YGH  GD+VL   A  + + + +   +AR GGEEF +  P  +     L
Sbjct: 238 DLDHFKQINDTYGHSVGDQVLREVAGRLAQHLRESDSLARWGGEEFLILAPETDLQQAYL 297

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           +A+++   +   P +     + +T+S+GV   R       D    L+  AD  +YR+K  
Sbjct: 298 LAQRLLGAIRESPISG----VQVTLSLGVACYR-----QGDSIAALLSRADEAMYRAKAG 348

Query: 301 GRNRTSTMRYGEEVV 315
           GRN+       E++V
Sbjct: 349 GRNQIVLEEELEDIV 363


>UniRef50_A3J8Q2 Two-component response regulator protein n=1 Tax=Marinobacter sp.
           ELB17 RepID=A3J8Q2_9ALTE
          Length = 379

 Score =  256 bits (655), Expect = 7e-67,   Method: Composition-based stats.
 Identities = 73/321 (22%), Positives = 125/321 (38%), Gaps = 26/321 (8%)

Query: 9   QFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIW 68
                +L  P ML       +   K  ++ P + L    + ++ + G     F   AL  
Sbjct: 56  HIIETLLRAPVMLVALFTLFVHYTKKPKVDPGLLL---RVIALSVMGLSLSLFVAHALYS 112

Query: 69  CAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSP-----------FSIPQMFSARLG 117
               Y      ++ F   ++  V          V                  Q+      
Sbjct: 113 PDTLYQMSNVLMIGFFGVSILSVRGLEQWRTFFVIPLMLFFAALAIVDLEFKQLIPFLFD 172

Query: 118 IATMAICPIMVSFSVAAINSLM----KQVALRADFDFLTQVYSRSGL---YEALKSPSLK 170
              M    ++VS S++ +        +Q+   A  D LT + +R  +    E L +   +
Sbjct: 173 PLVMIFLGMVVSGSLSQLRRSEFLSRQQLKSLASTDQLTGLLNRHAIHKSLEQLVARHAR 232

Query: 171 QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAV 230
                +++L D+D FK +ND+YGH  GD+VL   A  +Q  V    ++ R GGEE  V +
Sbjct: 233 HGHPFSLILGDLDKFKRVNDSYGHNVGDEVLIETANRLQDHVRAGDILCRWGGEELLVVL 292

Query: 231 PSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEA 290
           P       L +AEK+R  +   P T    ++  T+S GV           +  +  ++ A
Sbjct: 293 PDTERDSALAVAEKLRCAIGEAPMTAGGHSIEQTISFGVTCYH-----NGEHIDTTIMRA 347

Query: 291 DTCLYRSKKDGRNRTSTMRYG 311
           D+ LY +K+ GRNR  ++  G
Sbjct: 348 DSALYLAKQGGRNRVVSVEPG 368


>UniRef50_Q3ADQ4 Response regulator/sensory box protein/GGDEF domain protein n=1
           Tax=Carboxydothermus hydrogenoformans Z-2901
           RepID=Q3ADQ4_CARHZ
          Length = 668

 Score =  256 bits (655), Expect = 8e-67,   Method: Composition-based stats.
 Identities = 56/232 (24%), Positives = 100/232 (43%), Gaps = 13/232 (5%)

Query: 81  LTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMK 140
           L  +T   + +  A  ++    GS   + ++       +   +    +   +     L +
Sbjct: 442 LCLITAVGQEMDWAERILHRMDGSQLPVLKIVKRLRTKSGEKLIETFI--DLTERKKLEE 499

Query: 141 QVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGHECG 197
           Q+   +  D+LTQ Y+R    E L+    +  +      +++LDID+FK++ND +GH  G
Sbjct: 500 QLYRLSITDYLTQAYNRRYFTEMLEREIERAKRTKMPFALIMLDIDHFKNVNDRFGHAAG 559

Query: 198 DKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ 257
           D VL   A  I+  +     +AR GGEEF + +P+        +AE++R+ + +      
Sbjct: 560 DLVLKTLANLIKNRIRQTDCLARWGGEEFVILLPNTPVEKAAGLAEELREQLSMLEIPGV 619

Query: 258 QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
                +T S GV           D  + L++ AD  LY +K  GRN      
Sbjct: 620 G---RVTASFGVTGYCP-----GDTLDTLLMRADQMLYTAKASGRNCVRFSE 663


>UniRef50_C6WYA9 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Methylotenera
           mobilis JLW8 RepID=C6WYA9_METML
          Length = 548

 Score =  256 bits (654), Expect = 9e-67,   Method: Composition-based stats.
 Identities = 57/190 (30%), Positives = 102/190 (53%), Gaps = 8/190 (4%)

Query: 123 ICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVML 179
           I  I V  ++ +   L  ++  +A  D+LT++ +R    E  +    +  ++   + + +
Sbjct: 362 IRMIGVHANIHSRKLLELELNQKAHIDYLTELNNRGHFMEQAEKELSRSQRYQKDMAMFM 421

Query: 180 LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGL 239
           +DID+FK IND++GH+ GD VL   A   ++ + +  ++ R+GGEEFA+ +P  N  + L
Sbjct: 422 MDIDFFKKINDSHGHKIGDIVLKKLADVCRQTLREVDIIGRIGGEEFAILLPETNRAEAL 481

Query: 240 LMAEKIRKGVELQPFTWQQK-TLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSK 298
            +AE++R  V       +    +  TVSIGV S  ++     D+ + L+  AD  LY++K
Sbjct: 482 EVAERLRLAVADSKVPMKDGLPVQYTVSIGVSSVASA----DDNIDMLLSRADQALYQAK 537

Query: 299 KDGRNRTSTM 308
           + GRNR    
Sbjct: 538 QSGRNRVCAA 547


>UniRef50_A8ZX32 Diguanylate cyclase n=1 Tax=Desulfococcus oleovorans Hxd3
           RepID=A8ZX32_DESOH
          Length = 396

 Score =  256 bits (654), Expect = 9e-67,   Method: Composition-based stats.
 Identities = 71/335 (21%), Positives = 129/335 (38%), Gaps = 34/335 (10%)

Query: 4   DWFSEQFSTGVL----IVPCMLTLAIPGVLPRFKAEQMMPAIALIVS------------- 46
           +WF       +L     V  +L   I     R + +   P +  I+              
Sbjct: 62  EWFDRSIVIALLSLYGFVFVLLLYFILAAFHRRRQKSSWPLMENIMFGSYVVIVCAGSWF 121

Query: 47  -----VIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFV----TGAVEIVLVANSV 97
                   ++ +    S++  L  +    + Y      L+ F+    +G      +   +
Sbjct: 122 TGTYYTFGALFLFFGASISSSLADIRKVRLAYLASFGALVAFIVMDSSGMFRHAPLFTRI 181

Query: 98  IDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSR 157
                GSP  +       + ++   +  I +  +              +  D LT++ +R
Sbjct: 182 PLHPDGSPLPVWFGVQVFITVSLTIMLYITI-VTFKRWGVREDVYRKMSTVDGLTRLTNR 240

Query: 158 SGLYEALKSPS----LKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVG 213
               E  +        + + H++ +++DID+FK+IND YGH  GDKVL   A  + +   
Sbjct: 241 RTFIERSEKELSSGQRRPSSHISCIMIDIDHFKAINDTYGHAAGDKVLVKIATILTEKAR 300

Query: 214 DKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGR 273
               V R GGEEFA+ +P+      + +AE+ R  +           + +T S GV S  
Sbjct: 301 PTDEVGRYGGEEFAMLLPATTLAGAVKVAERQRASIANAEIIVDGNIIQVTASFGVASCP 360

Query: 274 ASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
           +  +   D+ N+L+  AD  LY +K+ GRNR    
Sbjct: 361 SDDI---DNINELLKTADVALYEAKRAGRNRVVAA 392


>UniRef50_A8GES9 Diguanylate cyclase n=2 Tax=Serratia RepID=A8GES9_SERP5
          Length = 500

 Score =  256 bits (654), Expect = 9e-67,   Method: Composition-based stats.
 Identities = 97/321 (30%), Positives = 162/321 (50%), Gaps = 19/321 (5%)

Query: 2   LADWFSEQFSTGVLIVPCMLTLA----------IPGVLPRFKAEQMMPAIALIV----SV 47
           LA W S +F+  + ++P +L                V  R +    +  IA+++    + 
Sbjct: 173 LALWLSSEFTNYITLMPFILAFPRDWKGYLRSIFQAVTLRSQWPNTVRKIAVLLLLLLAC 232

Query: 48  IASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFS 107
             S++IGG G++ FP+P L+W A+ ++   T ++  +   +   L  +  +  +      
Sbjct: 233 FGSILIGGPGAVIFPMPILLWLAMSFSLFST-MIAVLVYVLWCHLAIDLGLITTNLDMKM 291

Query: 108 IPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP 167
           +    S RLG+A +A+ PI V+    A N+L++++   A+ D LT V +RS   +     
Sbjct: 292 LQNTVSMRLGVALLALGPIAVASMNFARNALLQRLEHVANHDALTHVLTRSAFMQRGTRL 351

Query: 168 SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFA 227
             ++ + + +M+LDIDYFKSIND +GH  GD  L  F R I   + D  L  RMGGEEFA
Sbjct: 352 VSQKGERICIMMLDIDYFKSINDRFGHAGGDAALLSFTRAITGDLRDNDLFGRMGGEEFA 411

Query: 228 VAVPSVNPVDGLLMAEKIRKGVELQPFTWQ-QKTLYLTVSIGVGSGRASYLTLTDDFNKL 286
           +  P     D L +AE++R  VE++         L +TVSIG+ +          + + L
Sbjct: 412 IVAPIAQQQDALSLAERLRHRVEIESINMPAGAALQITVSIGMVTCIGG---SGQNLDNL 468

Query: 287 MVEADTCLYRSKKDGRNRTST 307
           +  AD  +Y++K  GRNR +T
Sbjct: 469 LKIADLAVYKAKNSGRNRVAT 489


>UniRef50_B4VVS2 GGDEF domain protein n=1 Tax=Microcoleus chthonoplastes PCC 7420
           RepID=B4VVS2_9CYAN
          Length = 314

 Score =  255 bits (652), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 55/264 (20%), Positives = 107/264 (40%), Gaps = 7/264 (2%)

Query: 48  IASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFS 107
           +  + +         L   +      T     L+  V     ++         ++  PF+
Sbjct: 55  LIIMALTMPKMSGLELCDYLKSPPPLTTSPIILMRTVREQEYLIEAFEKGAADTITHPFN 114

Query: 108 IPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP 167
             ++ +       +      ++  V     L   +   A  D LT +++R          
Sbjct: 115 PAEILARVRTHLELKQTQKQLNRLVKEHEKLANLLRKLAITDPLTGLWNRRHFLTVAYQE 174

Query: 168 ---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGE 224
              + +  + ++++++DID+FK IND YGH  GD+VL   A+ I   + +     R GGE
Sbjct: 175 FNRASRYKRFMSILMIDIDHFKQINDEYGHTMGDEVLKGVAKSIVGSLREADYCGRFGGE 234

Query: 225 EFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFN 284
           EF   +P  +    + +AE++RK +E        K + +TV++GV S +        +  
Sbjct: 235 EFVTLLPETDSSGAVRVAERLRKRMEQITIGIGDKQVQMTVTVGVASYQ----LDDANIE 290

Query: 285 KLMVEADTCLYRSKKDGRNRTSTM 308
            ++  A+  LY +K  G NR +  
Sbjct: 291 VIIQRANKALYHAKSQGYNRVALH 314


>UniRef50_B3E6Y7 Diguanylate cyclase n=1 Tax=Geobacter lovleyi SZ RepID=B3E6Y7_GEOLS
          Length = 459

 Score =  255 bits (652), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 55/187 (29%), Positives = 86/187 (45%), Gaps = 8/187 (4%)

Query: 129 SFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYF 185
           +  +  +    +++   A  D LT + +R    E ++    +  +       +LLDID F
Sbjct: 274 NRFLKELREAQEKLVEMATIDSLTGLLNRRAGLERVEEELSRHQRSERAFACLLLDIDRF 333

Query: 186 KSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKI 245
           K IND YGH+ GD VLS F   +++ V    +V R GGEEF + +P  +P      AEKI
Sbjct: 334 KKINDTYGHQAGDAVLSEFGATLRRHVRKHDIVCRYGGEEFLLLLPDTSPSAARTTAEKI 393

Query: 246 RKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
           R      P  +  + + +T SIG+   +       +    ++  AD  LY +K  GRNR 
Sbjct: 394 RAVTAATPIMFAGRQIAVTTSIGISMMQG-----DETAKAMIARADAALYEAKNSGRNRV 448

Query: 306 STMRYGE 312
                 E
Sbjct: 449 VCAEANE 455


>UniRef50_B3EBI3 Diguanylate cyclase n=1 Tax=Geobacter lovleyi SZ RepID=B3EBI3_GEOLS
          Length = 307

 Score =  255 bits (651), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 57/189 (30%), Positives = 90/189 (47%), Gaps = 8/189 (4%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLL 180
              +    V        ++   A  D LT V++R  L   L+    +  +    L++M+L
Sbjct: 117 AIYITVQDVTDFVIYEHKLIQMAKVDGLTGVFNRRYLDTRLQEELERSRRHGNPLSIMML 176

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DID+FK IND +GH CGD  L   +  + ++V    ++ R GGEEF   +P  +    L+
Sbjct: 177 DIDHFKEINDTHGHICGDYTLRKISELLLELVRTSDILGRYGGEEFCCILPETSFEQALV 236

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           +AE+ R  V    F+       +TVSIGV       L   D  + ++  AD  LY++K+ 
Sbjct: 237 LAERCRTQVAASQFSCTDHQSRVTVSIGVT-----DLHRDDTLDSIIKRADDALYQAKRT 291

Query: 301 GRNRTSTMR 309
           GRNR  +  
Sbjct: 292 GRNRVCSSP 300


>UniRef50_B8DLV9 Diguanylate cyclase n=4 Tax=Desulfovibrio vulgaris
           RepID=B8DLV9_DESVM
          Length = 381

 Score =  255 bits (651), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 72/284 (25%), Positives = 121/284 (42%), Gaps = 15/284 (5%)

Query: 31  RFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEI 90
           R         +AL    +  V  GG     F +   I+  V        +   + GA+ +
Sbjct: 83  RHVLPSTALVLALFTLSLYMVSHGGVEGSGF-VWLFIFPPVVMLTFGLSIGILLMGALLL 141

Query: 91  VLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINS------LMKQVAL 144
            + A   +           Q F  R  +A +              ++      L +Q+A 
Sbjct: 142 GVGAILFLPGDPFLYADYSQAFRIRYMLALLCCGIFAGLAEYTRRHTQRLLILLTQQLAE 201

Query: 145 RADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVL 201
            A  D LT + +R  L E L+     + +  + L++ + DID+FKS+ND YGH+CGD VL
Sbjct: 202 SARTDELTGLANRRALCERLEYEQVRARRTGRPLSIAICDIDHFKSVNDCYGHQCGDLVL 261

Query: 202 SVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTL 261
              A  +   +  +  + R GGEEF + +P  +      +AEK+R  VE   +++    +
Sbjct: 262 QSVAGLLHDNLRHQDTICRWGGEEFLLLLPETDEAGAARLAEKLRSLVEAMEYSYHGIPV 321

Query: 262 YLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
            +T+S GV +          D +  + +AD  LY +K+ GRNR 
Sbjct: 322 SVTLSFGVHTCGPEG-----DIDYHIRKADQKLYLAKEQGRNRV 360


>UniRef50_C6C0X5 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfovibrio
           salexigens DSM 2638 RepID=C6C0X5_DESAD
          Length = 779

 Score =  254 bits (650), Expect = 3e-66,   Method: Composition-based stats.
 Identities = 54/187 (28%), Positives = 94/187 (50%), Gaps = 7/187 (3%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLL 180
             +     V        ++   A  D LT + +R    E+ +     + +  + L+++++
Sbjct: 587 WVVGTFRDVTERKEAEDKLRKLATTDSLTGLSNRRFFMESAEDALERTRRYGRDLSLLMM 646

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DIDYFK++ND YGH+ GD VL   ++   KI+ +  +  R+GGEEF++ +P        L
Sbjct: 647 DIDYFKTVNDMYGHDAGDDVLKGLSKTGLKILRNIDVFGRIGGEEFSILLPDTGLDGATL 706

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           +AE++R  +E      +  +L +TVSIGV +        T    +L+  AD  LY +K+ 
Sbjct: 707 VAERLRAEIETTKMNTRSGSLNITVSIGVATYS----EHTKTLEQLLKAADIGLYAAKEA 762

Query: 301 GRNRTST 307
           GRN+   
Sbjct: 763 GRNQVKV 769


>UniRef50_C6BW86 Diguanylate cyclase n=1 Tax=Desulfovibrio salexigens DSM 2638
           RepID=C6BW86_DESAD
          Length = 555

 Score =  254 bits (650), Expect = 3e-66,   Method: Composition-based stats.
 Identities = 68/270 (25%), Positives = 115/270 (42%), Gaps = 16/270 (5%)

Query: 44  IVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVG 103
           I S + + + G   +L    P  I      +  +  L +      E              
Sbjct: 287 IYSFLWTAIGGAFLTLLIITPFSIKLIQSISIPLKRLSSVARQMTEGKFDCECTGTGVSH 346

Query: 104 SPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYE- 162
            P  + Q+      +                ++  ++++   A  D LT + +R  L + 
Sbjct: 347 PPEEVTQLIDGFCAMQG-------------KVDRTVQELQKSAVTDQLTGLPNRRYLMKE 393

Query: 163 --ALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVAR 220
              L   +++  Q  ++M++DID+FK IND YGH  GD VL   ++  Q++V    ++AR
Sbjct: 394 GTRLVDIAIRAGQPCSLMIMDIDHFKVINDTYGHTVGDIVLQQISKAFQEVVRSSDIIAR 453

Query: 221 MGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLT 280
            GGEEF V  P  +   G  +AE++R+ VE + F   ++ L  T+SIGV           
Sbjct: 454 YGGEEFVVVAPGSDIDSGRTLAERLRQSVEARIFNNDEQPLTCTISIGVSHYATDIKFGV 513

Query: 281 DDFNKLMVEADTCLYRSKKDGRNRTSTMRY 310
           D +  ++  AD  LY++K  GRNR      
Sbjct: 514 DAYEDMLARADNALYKAKDTGRNRICIAEP 543


>UniRef50_C6DJJ8 Diguanylate cyclase n=1 Tax=Pectobacterium carotovorum subsp.
           carotovorum PC1 RepID=C6DJJ8_PECCP
          Length = 480

 Score =  254 bits (650), Expect = 3e-66,   Method: Composition-based stats.
 Identities = 82/322 (25%), Positives = 156/322 (48%), Gaps = 23/322 (7%)

Query: 5   WFSEQFSTGVLIVPCMLTLAI----------PGVLPRFKAEQMMPAIALIVSVIASVVIG 54
           WFSE+ S+GV+ V   L +              +   FK    +    +I+  IAS+ I 
Sbjct: 164 WFSEELSSGVIFVFLFLKVTRNVKNIFKISTSSIKKTFKKPLFILYPIIIIFCIASLNIT 223

Query: 55  GAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVID--ISVGSPFSIPQMF 112
                   +  LI+ ++ ++     L+   TG     +  N +I+   ++   +     +
Sbjct: 224 ---LSVLAILPLIYLSLSHSFNKIILMCTATGIALNYIYINRLINVHDTIEKEYLFELSY 280

Query: 113 SARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKS--PSLK 170
             ++  + + I  ++ SF +      +K++ L ++ D LT + +R  L + + +   S +
Sbjct: 281 LFQINTSVIIITVLIASFFINKNRKNIKRIELISNHDALTGMLNRRSLNQHMMNIINSTR 340

Query: 171 QTQH--LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAV 228
              +  +++++LDID+FK +ND YGH  GD V+  F+  +++    + L+ R GGEEF +
Sbjct: 341 DGDNKIMSLLVLDIDHFKKVNDTYGHAVGDNVIREFSTTLKQYTRPQDLLCRWGGEEFLI 400

Query: 229 AVPSVNPVDGLLMAEKIRKGVELQPFTW-QQKTLYLTVSIGVGSGRASYLTLTDDFNKLM 287
            +  ++  D L +AE+IR  +E  P        +  T SIGV   +   L   +DF++  
Sbjct: 401 IIQGLSVNDCLDIAERIRSIIEGAPLAISDGHIVRCTTSIGVSFFQ---LERIEDFHEAF 457

Query: 288 VEADTCLYRSKKDGRNRTSTMR 309
            EAD  LY +K+ GRNR ++++
Sbjct: 458 KEADELLYMAKEQGRNRVNSVQ 479


>UniRef50_C8X5B9 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8X5B9_DESRD
          Length = 578

 Score =  254 bits (649), Expect = 3e-66,   Method: Composition-based stats.
 Identities = 57/189 (30%), Positives = 90/189 (47%), Gaps = 6/189 (3%)

Query: 122 AICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVM 178
               +  +  +       + +   A  D LT +Y+R    E L      + +  Q L ++
Sbjct: 392 ITSIVGSAQDITERKRAEEHLRYLATTDELTGLYNRRHFMEILDTEIERAKRYEQSLALI 451

Query: 179 LLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDG 238
            LDID+FK+IND +GH  GD  L   A  +         + R+GGEEFA+  P  +    
Sbjct: 452 SLDIDHFKTINDTHGHAVGDAALEHLAAQLLACKRQPDSLGRLGGEEFALIAPHTDRAGA 511

Query: 239 LLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSK 298
             +AE+IR  +E  P   +  +L+ T+S+GV +     +   D  + L+  AD  LY +K
Sbjct: 512 TELAERIRSELERTPIELESTSLHPTISLGVTALN---IQDNDTIDALLKRADDALYEAK 568

Query: 299 KDGRNRTST 307
           + GRNRT T
Sbjct: 569 RTGRNRTVT 577


>UniRef50_A0YVG8 GGDEF/response regulator receiver domain protein n=1 Tax=Lyngbya
           sp. PCC 8106 RepID=A0YVG8_9CYAN
          Length = 329

 Score =  253 bits (648), Expect = 4e-66,   Method: Composition-based stats.
 Identities = 57/246 (23%), Positives = 106/246 (43%), Gaps = 21/246 (8%)

Query: 77  VTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAIN 136
               LT       ++          +  PF  P++ +            + + ++   +N
Sbjct: 83  PVIFLTASEEKEHLLEAFKQGAVDYITKPFYAPELLAR-------VRVHLELKYTKDELN 135

Query: 137 SLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVMLLDIDYFKSINDNYG 193
                   +A  D LT +++R  L    E     ++   +  ++++LDID+FK +ND YG
Sbjct: 136 KKSAAFEKQAITDPLTGIFNRRHLMSISEIEYQKAVNYNRLFSIIMLDIDHFKKVNDTYG 195

Query: 194 HECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP 253
           H  GD+VL    + +Q ++ +  +  R GGEEFA+ +P  +    L +AE++R+ +    
Sbjct: 196 HIVGDQVLKRMTQEVQNLLREGDVCGRFGGEEFAIILPGADLKIALKIAERLRQAIADFY 255

Query: 254 FTWQQK------TLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS- 306
                        + +T+S+GV +         D  +K+   AD  LY++K  GRN+   
Sbjct: 256 IPIYDSNSSSNLKIKITISLGVTTYH----IDDDKLDKMWRRADDALYQAKAKGRNQVCS 311

Query: 307 TMRYGE 312
               GE
Sbjct: 312 IYEPGE 317


>UniRef50_B7K273 Response regulator receiver modulated diguanylate cyclase n=6
           Tax=Cyanobacteria RepID=B7K273_CYAP8
          Length = 308

 Score =  253 bits (648), Expect = 5e-66,   Method: Composition-based stats.
 Identities = 60/263 (22%), Positives = 105/263 (39%), Gaps = 14/263 (5%)

Query: 48  IASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFS 107
           +  + +         +  ++             LT       ++          V  PF 
Sbjct: 55  LILLDLMMPEINGLEVCKILKSDEATANIPILFLTASNDKEHLIKAFEQGAVDYVTKPFK 114

Query: 108 IPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP 167
           +P++ +            + +      +    + +   AD D LT + +R  L E  +  
Sbjct: 115 VPELLAR-------VKTHVELKQVQKQLQEACQTMKKLADTDELTGIANRRCLLEFAQRE 167

Query: 168 SLK---QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGE 224
             +         ++++D+D+FK+IND YGH  GDK +      I+  + +     R GGE
Sbjct: 168 FQRSLRYGTPFCLLMIDVDHFKNINDKYGHPNGDKAIQWVVEIIKLGLREVDFFGRFGGE 227

Query: 225 EFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFN 284
           EF V +P       L +AE+IR+ +  QP T +Q T+ LT SIGV +             
Sbjct: 228 EFIVVLPQTALGGALEVAERIREAIASQPLTLEQDTVTLTASIGVATYTGE----DKTVV 283

Query: 285 KLMVEADTCLYRSKKDGRNRTST 307
            ++  AD  LY++K  GRN+   
Sbjct: 284 GMIQRADKSLYQAKAKGRNQVIA 306


>UniRef50_A1U2H0 Diguanylate cyclase n=2 Tax=Marinobacter RepID=A1U2H0_MARAV
          Length = 630

 Score =  253 bits (648), Expect = 5e-66,   Method: Composition-based stats.
 Identities = 81/337 (24%), Positives = 136/337 (40%), Gaps = 34/337 (10%)

Query: 2   LADW-FSEQFSTGVLIVPCMLT----LAIPGVLPRFKAEQMMPAIALIVSV--------- 47
           L  W ++   + G+L +  +L     L +P +L  F     M  ++++  +         
Sbjct: 284 LNRWTWAMIMTAGMLALAGLLIPYQWLILPSILVAFVGCSTMLMLSVVRWIKKDPAARYY 343

Query: 48  IASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFS 107
             + V    G +   L            +    +    G + + +     ++      F+
Sbjct: 344 TVAWVFMLFGGIVLALSKFTMLPRNLLTENATQVGSALGVILLSIALADRLNREKKKSFA 403

Query: 108 IPQMF-------------SARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQV 154
             Q               S R+     A+    V      +  L +Q+   +  D LT +
Sbjct: 404 AQQKLLREERKARLAQEKSLRIQQEANALLEERVQERTRDLEILNEQLLELSATDPLTGL 463

Query: 155 YSRSGLYEALKS---PSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKI 211
            +R    +  +S    + +  + L+++++DID+FK  ND YGH  GD  L + A  I++ 
Sbjct: 464 KNRGHFDKKFQSDVVHAYRFEETLSLLIVDIDHFKGFNDTYGHLVGDDCLKMVADCIKQH 523

Query: 212 V-GDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVG 270
           V   + L AR GGEEF V +P         +AE IR+ ++   F    + L+LTVSIGV 
Sbjct: 524 VTRPQDLAARYGGEEFVVLLPDTPEAGACRVAELIREDIQKMAFRVSDQVLHLTVSIGVC 583

Query: 271 SGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
           S   S     D    L   AD  LYR+K +GRNR   
Sbjct: 584 SCAPSQ---ADATKALFACADGALYRAKAEGRNRVVA 617


>UniRef50_C0N773 GGDEF domain protein n=1 Tax=Methylophaga thiooxidans DMS010
           RepID=C0N773_9GAMM
          Length = 462

 Score =  253 bits (648), Expect = 5e-66,   Method: Composition-based stats.
 Identities = 67/263 (25%), Positives = 123/263 (46%), Gaps = 14/263 (5%)

Query: 53  IGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMF 112
           I G     + +   I   +     +      VT       + N+ + +S      +  ++
Sbjct: 207 INGILDQRYAMSVGIRSDLPLLLSIYNKAIAVTTEETRQQILNNWLSLSFHQNVDLTWLW 266

Query: 113 SARLGIATMAICP----IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPS 168
              + IA +        ++V+     +  + K++   +  D LT +++R  L +A +   
Sbjct: 267 RMLIVIAVVVALFFYRYLLVNQHNRELQRVNKKLEQLSQRDHLTGIHNRYYLDQAFQQEL 326

Query: 169 LKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEE 225
            +  ++    T+++LDID FK IND+YGH  GD V+   A  +++ V D+ +VAR GGEE
Sbjct: 327 TRYKRYQHGFTIVMLDIDLFKQINDSYGHVVGDDVIKQIAMLLREHVRDQDVVARWGGEE 386

Query: 226 FAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNK 285
           F +  P  +      +AE +R+ +   PFT     + +TVS GV   RA      +D   
Sbjct: 387 FLILNPETSLDGARTLAEHLRRLIRRTPFTVD--KIDVTVSFGVTDYRA-----GEDIET 439

Query: 286 LMVEADTCLYRSKKDGRNRTSTM 308
           ++  AD+ LY++K+ GR++T   
Sbjct: 440 MIQRADSALYQAKQSGRDKTVVF 462


>UniRef50_Q310L5 Diguanylate cyclase (GGDEF domain) n=2 Tax=Desulfovibrio
           RepID=Q310L5_DESDG
          Length = 525

 Score =  253 bits (647), Expect = 6e-66,   Method: Composition-based stats.
 Identities = 64/174 (36%), Positives = 98/174 (56%), Gaps = 6/174 (3%)

Query: 138 LMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGH 194
           L +++ L+AD D LTQ+++R      L+    +  +    LT+M+LDIDYFK IND +GH
Sbjct: 343 LFREMRLQADHDGLTQLHNRRHFDTRLREELDRHGRYSMPLTLMMLDIDYFKQINDRFGH 402

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
           + GD VL   A  +++ +      AR GGEEF   +P  +     ++AE++RK +E + F
Sbjct: 403 QAGDAVLRELASVLRETIRTTDYCARYGGEEFVAILPHTDEQQARVLAERLRKNIESRVF 462

Query: 255 TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
               KT+  TVSIG+   +   LT     ++L+ EAD  LY +K +GRN   T 
Sbjct: 463 RHHGKTIQATVSIGLTGFKPGALTPR---DELVREADAALYLAKANGRNVVCTF 513


>UniRef50_C3JIZ7 Diguanylate cyclase n=2 Tax=Rhodococcus erythropolis
           RepID=C3JIZ7_RHOER
          Length = 471

 Score =  253 bits (647), Expect = 6e-66,   Method: Composition-based stats.
 Identities = 100/321 (31%), Positives = 150/321 (46%), Gaps = 20/321 (6%)

Query: 5   WFSEQFSTGVLIVPCMLTLAI-------PGVLPRFKAEQMMPAIALIVSVIASVVIGGAG 57
           WFS +F   + IVP +LT          P  +       ++P   L V +I   VIGGAG
Sbjct: 158 WFSSEFVNYMTIVPLVLTFPSLRRVDREPKAVATLLRRSVVPTALLAVCIILEWVIGGAG 217

Query: 58  SLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLG 117
           ++AF +PAL+  A+     VT +LT V+ A  +VL A+  + +S  S    P   S ++G
Sbjct: 218 AIAFAMPALVTAALLTNVFVTSVLTAVSTAWTLVLTADGHLGLS--SEGVSPVSASVQIG 275

Query: 118 IATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEA------LKSPSLKQ 171
           ++ +A+ PI V+  +      ++ +      D LT    R               P    
Sbjct: 276 LSLLAVAPIAVACVILERRRALEALTQAVTHDDLTGALRRDEFLRRGGSVTGATDPRRHS 335

Query: 172 TQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVP 231
            + ++V+++D+D+FK +NDN GH  GD  L  FA  +++ + DK L AR+GGEEF V + 
Sbjct: 336 GRPVSVLMMDLDHFKMVNDNLGHRAGDTALVSFADQVRRHLDDKHLFARLGGEEFVVLMA 395

Query: 232 SVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEAD 291
            V+       AE IR+                TVSIGV            D  +L+  AD
Sbjct: 396 GVDLEGATETAEMIRRAQAENSSAVLGD-FGPTVSIGVAC----SPHGDADLTQLVDCAD 450

Query: 292 TCLYRSKKDGRNRTSTMRYGE 312
             LYR+KK  RNRT  +  G 
Sbjct: 451 EALYRAKKLDRNRTVALTVGS 471


>UniRef50_B1WQB8 Putative diguanylate cyclase n=2 Tax=Cyanothece RepID=B1WQB8_CYAA5
          Length = 493

 Score =  253 bits (647), Expect = 7e-66,   Method: Composition-based stats.
 Identities = 74/258 (28%), Positives = 122/258 (47%), Gaps = 16/258 (6%)

Query: 58  SLAFPLPALIWCAVRYTPQVTCLLTF-VTGAVEIVLVANSVIDISVGSPFSIPQMFSARL 116
            +A+PL  L   A R T +    L   VT   E+  +A S+  +       I ++  AR 
Sbjct: 241 IIAYPLEQLTHIAQRVTQESNFQLKAPVTTQDEVGKLATSMNQLIQWIDEHITELKEARQ 300

Query: 117 GIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH-- 174
            +         V      +   +K++    + D LTQ+++R    E L     +  +   
Sbjct: 301 TLEKR------VEQRTIELQQALKKLKALVNLDGLTQIFNRRYFDEVLYREWQRGRREKS 354

Query: 175 -LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIV-GDKGLVARMGGEEFAVAVPS 232
            ++++L D+DYFK  N+ YGH  GD  L   A+ I++ V     LVAR GGEEF + +P+
Sbjct: 355 VISLILCDVDYFKIYNETYGHLGGDSCLQEVAQGIRRQVKRPSDLVARYGGEEFVILLPN 414

Query: 233 VNPVDGLLMAEKIRKGVELQPFTWQQKTL--YLTVSIGVGSGRASYLTLTDDFNKLMVEA 290
            +    L +AE IR  +E      +   +  ++T+S+GV S        TD++  L+ EA
Sbjct: 415 TDLNGALALAEMIRNAIEAMNIPHENSLVSDHVTISMGVTS---KIPQETDEYEHLIEEA 471

Query: 291 DTCLYRSKKDGRNRTSTM 308
           D  LY++K++GRN     
Sbjct: 472 DDALYQAKENGRNCVCYF 489


>UniRef50_A4BG19 GGDEF domain protein n=1 Tax=Reinekea blandensis MED297
           RepID=A4BG19_9GAMM
          Length = 377

 Score =  253 bits (646), Expect = 7e-66,   Method: Composition-based stats.
 Identities = 82/305 (26%), Positives = 130/305 (42%), Gaps = 13/305 (4%)

Query: 10  FSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAG----SLAFPLPA 65
           F+   L +   + L I      F     +  + L V  +  V  GGA        + LP 
Sbjct: 66  FTAFALFLFAHIQLRIKRNQSAFLFAARLVQLVLFVLCLYLVYAGGANQTGPLWVYLLPP 125

Query: 66  LIWCAVRYTPQVTCLLTFVTGAVEIVLV-ANSVIDISVGSPFSIPQMFSARLGIATMAIC 124
           ++         +     FV G + IV    N++  +     F    ++S        A+ 
Sbjct: 126 VVMFLSGLKRGMMITALFVLGYLIIVFFPGNALGAVDYSYEFKTRLLYSFLTLTFLAAVY 185

Query: 125 PIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLD 181
                 S   +N L +    +A  D LT + +R G+ E ++     S +  Q +T +L D
Sbjct: 186 EQSRQSSYQKLNELKQDFERQASQDTLTHLLNRRGMRERIRYEVRRSQRNNQPITFILAD 245

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           +D+FK IND+YGH+ GD VL   ++ +Q  V  +  +AR GGEEF   +P  N    + +
Sbjct: 246 LDHFKEINDHYGHDTGDTVLIQVSQLLQDSVRQQDSIARWGGEEFLFLLPETNARQAMQL 305

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
           AEKIR  +E  P    Q  L  T+S G+           ++    + EAD  LY++K  G
Sbjct: 306 AEKIRSIIESHPLNSDQPPLTTTMSFGIAEM-----LDLENHQSTIAEADNRLYQAKSQG 360

Query: 302 RNRTS 306
           RN   
Sbjct: 361 RNCVV 365


>UniRef50_C6BVV0 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfovibrio
           salexigens DSM 2638 RepID=C6BVV0_DESAD
          Length = 838

 Score =  253 bits (646), Expect = 9e-66,   Method: Composition-based stats.
 Identities = 58/194 (29%), Positives = 98/194 (50%), Gaps = 8/194 (4%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLK---QTQHLTVMLL 180
             I V++ V        Q+   A  D +T++ +R    E +KS   +    ++ L++++ 
Sbjct: 649 LLIGVNWDVTESREKENQLRRMATTDDMTKLNNRRYFIELVKSEIERSIRYSRPLSLVMF 708

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           D+D FK++ND YGH+ GD VL   A   + ++ D  ++ R+GGEEFAV +P  +    +L
Sbjct: 709 DVDKFKAVNDTYGHDVGDMVLKAIAATAKGVLRDVDIIGRLGGEEFAVGLPETDLKGAML 768

Query: 241 MAEKIRKGVELQPFTW-QQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKK 299
           +AE++R  +E           +  TVS+GV     S      D + L+  AD  LY +K+
Sbjct: 769 LAERLRVVLEEASVELPDGGIVDFTVSLGVAVLDRSI----TDVDVLLKHADLALYAAKE 824

Query: 300 DGRNRTSTMRYGEE 313
           +GRNR        +
Sbjct: 825 NGRNRVEAYTQMMD 838


>UniRef50_A1TWP6 Diguanylate cyclase n=2 Tax=Marinobacter RepID=A1TWP6_MARAV
          Length = 565

 Score =  252 bits (645), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 78/304 (25%), Positives = 122/304 (40%), Gaps = 14/304 (4%)

Query: 15  LIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYT 74
           +I    L      V              L    + +      G L   +  L W      
Sbjct: 260 IIWISSLAAFATPVAWLIGINVWRRGQILGGFYVLAWTPLLLGHLVLAVSKLGWIP---R 316

Query: 75  PQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPI--MVSFSV 132
              T L      AVE++L++ ++            Q     L I   A   +   V    
Sbjct: 317 SPFTELAPQAGVAVEVILLSFALAYRINMERRRRQQAQEHALDIQRQANLTLESRVRERT 376

Query: 133 AAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSIN 189
             +    +Q+   +  D LT V +R    E L++    +L+    L+++LLDID+FK +N
Sbjct: 377 EELEQANEQLRAISLTDGLTHVANRRRFDEKLETEWNRALRHEHELSLILLDIDHFKQVN 436

Query: 190 DNYGHECGDKVLSVFARHIQKIV-GDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKG 248
           D +GH  GD  L   A  +   V     LVAR GGEEFA+ +P+ +      +AE++R  
Sbjct: 437 DRFGHLVGDDCLVALASILSDEVQRSGDLVARYGGEEFAILLPTTDVAGAQQVAERMRLS 496

Query: 249 VELQPFTWQQK--TLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
           V   P    +    + LT+S+GV +   +  +   D  +L+  AD  LY +K DGRNR  
Sbjct: 497 VARTPVNSGEHMSPVSLTISLGVATLTPNRQS---DCQELIRRADEALYAAKSDGRNRVV 553

Query: 307 TMRY 310
               
Sbjct: 554 VWHP 557


>UniRef50_C0QT79 Signal transduction response regulator n=1 Tax=Persephonella marina
           EX-H1 RepID=C0QT79_PERMH
          Length = 509

 Score =  252 bits (645), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 60/202 (29%), Positives = 95/202 (47%), Gaps = 14/202 (6%)

Query: 109 PQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK--- 165
                + +GI  +    + +SF +  I    ++    A+ D LT +Y++      L+   
Sbjct: 308 NTFIISYVGINLLVGLLLTMSFILGVIK---ERFKAMAEIDTLTGIYNKGKFNHLLQVEL 364

Query: 166 SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEE 225
             S +  + L++++ DID+FK IND +GH+ GD VL   A+ +   +      AR GGEE
Sbjct: 365 DRSKRYGRPLSLIIFDIDHFKKINDAFGHQAGDYVLKTLAKIVSSNIRSTDFFARWGGEE 424

Query: 226 FAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNK 285
           F +  P  +     ++AEKIRK +E  PF    K   +T S GV           D  + 
Sbjct: 425 FVILAPETDLEGAQILAEKIRKAIEEYPFETVGK---VTSSFGVTE-----AFENDTVDS 476

Query: 286 LMVEADTCLYRSKKDGRNRTST 307
            +  AD  LY++K  GRNR   
Sbjct: 477 FVKRADVALYKAKDKGRNRVEI 498


>UniRef50_Q1N175 Diguanylate cyclase (GGDEF domain) n=1 Tax=Bermanella marisrubri
           RepID=Q1N175_9GAMM
          Length = 294

 Score =  252 bits (644), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 63/235 (26%), Positives = 106/235 (45%), Gaps = 22/235 (9%)

Query: 77  VTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAIN 136
              L+T       +V   +      V  P+S+  + +                 S     
Sbjct: 78  PVILVTANGDDQNVVDGLDLGAVDYVIKPYSLSVLLARV--------------RSALREK 123

Query: 137 SLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYG 193
             +  +   A  D LT +Y+R   +E  +    +  ++    + ++LDID+FK +ND YG
Sbjct: 124 ERLDLMEKWATTDPLTGLYNRRFFFEQAQRELERVQRNETDASFIILDIDHFKKVNDEYG 183

Query: 194 HECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP 253
           H  GD VL   A+  ++      L  R GGEEF + +P  +    LL+AE+ RK VE   
Sbjct: 184 HLVGDDVLEGLAKLFKETFRKVDLCCRFGGEEFVICLPDTDTEGALLVAERTRKKVEELS 243

Query: 254 FTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
           F  ++  L++T+S+GV S              ++  AD  LY++K++GRNRT ++
Sbjct: 244 FNTEKGPLHVTISLGVSSAN-----ENTTLEDMLKRADDALYQAKQNGRNRTESL 293


>UniRef50_C5SA57 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Allochromatium
           vinosum DSM 180 RepID=C5SA57_CHRVI
          Length = 434

 Score =  252 bits (644), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 50/199 (25%), Positives = 90/199 (45%), Gaps = 6/199 (3%)

Query: 119 ATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLK---QTQHL 175
           A   +  + +   +     L + +      D LTQ+++R   +   +    +       +
Sbjct: 234 AGQVVGAMEIIRDITDSKRLEEDLRQLTRLDPLTQLFNRRYFFTLAEQEYQRFLRYHHPM 293

Query: 176 TVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNP 235
            + ++DID+FKS+ND YGH  GD VL + A+ +   +    ++AR GGEEF + +P  + 
Sbjct: 294 ALCMIDIDHFKSVNDRYGHLVGDTVLCIVAQTLHDNLRQVDILARYGGEEFVILLPETDL 353

Query: 236 VDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLY 295
                  E++R  V  +        + +T+S+GV +             +L+  AD  LY
Sbjct: 354 QTACASTERLRVAVAERRIETPSGPVSVTLSLGVVAIADG---PAMTLERLLDAADQMLY 410

Query: 296 RSKKDGRNRTSTMRYGEEV 314
           R+K+ GRNR      G  +
Sbjct: 411 RAKQAGRNRVEIWDLGRSM 429


>UniRef50_D2L2K3 Diguanylate cyclase with GAF sensor n=1 Tax=Desulfovibrio sp.
           FW1012B RepID=D2L2K3_9DELT
          Length = 499

 Score =  252 bits (644), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 62/183 (33%), Positives = 93/183 (50%), Gaps = 11/183 (6%)

Query: 141 QVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGHECG 197
           QV +RAD D LT++++R    E L     +  +    +++++LDID+FK IND YGH  G
Sbjct: 314 QVKVRADHDGLTRIHNRRAFDERLVEELRRHQRYHHPMSLLMLDIDHFKGINDTYGHLVG 373

Query: 198 DKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ 257
           D VL    R + + +      AR GGEEF + +P        ++AE++R  +    F   
Sbjct: 374 DHVLREVGRLMTETLRSTDFTARYGGEEFVIILPQTAEEQSRVLAERLRGLIADARFVHD 433

Query: 258 QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM-----RYGE 312
                +TVSIG  +     L+   D   L+ +AD  LY++K  GRN+  T      R GE
Sbjct: 434 GHPFSITVSIGAATLLPGALSKRKD---LLDKADKALYQAKTLGRNQVCTALGPVSRTGE 490

Query: 313 EVV 315
           E V
Sbjct: 491 EAV 493


>UniRef50_A3Y6S3 PAS:GGDEF protein n=1 Tax=Marinomonas sp. MED121 RepID=A3Y6S3_9GAMM
          Length = 299

 Score =  252 bits (644), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 57/183 (31%), Positives = 94/183 (51%), Gaps = 7/183 (3%)

Query: 126 IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDI 182
           + +   V        ++   +  D LT + +R    E  +    +      H +++ LDI
Sbjct: 117 VSIQRDVTEYIYTQNKLEELSRTDPLTGLINRRVFDEMAEKEFYRYQNQNIHYSLLALDI 176

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           DYFK IND YGH  GD VL+ F+   +K +  +  +AR+GGEEF + +P+ + V  + +A
Sbjct: 177 DYFKRINDKYGHLTGDYVLASFSTLCEKNIRSQDKIARIGGEEFCIILPATDKVGAIEVA 236

Query: 243 EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           EK+R+ +    F   +  + +TVSIGV   + S      D+  ++  AD  LYR+K  GR
Sbjct: 237 EKLRRAISNARFKQDEHEIAVTVSIGVSQVKMS----DYDYVAMLKRADENLYRAKHQGR 292

Query: 303 NRT 305
           N+ 
Sbjct: 293 NQV 295


>UniRef50_D1U9C4 Diguanylate cyclase n=1 Tax=Desulfovibrio aespoeensis Aspo-2
           RepID=D1U9C4_9DELT
          Length = 498

 Score =  252 bits (644), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 63/175 (36%), Positives = 97/175 (55%), Gaps = 6/175 (3%)

Query: 140 KQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHEC 196
           K+V LRAD D LT++Y+R    E L     ++ ++   L+++++D+D+FK +ND YGH+ 
Sbjct: 319 KEVKLRADRDGLTRIYNRHSFDERLIYEIKRRRRYNHDLSLLMVDLDHFKQVNDTYGHKA 378

Query: 197 GDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTW 256
           GD VL      + +      L AR GGEEF V +P  +      +AE+IR+ ++   F +
Sbjct: 379 GDMVLRKVGEILTETFRTTDLAARYGGEEFVVLLPHTSEEAAWKLAERIRESIQGCVFRF 438

Query: 257 QQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYG 311
                 +T SIGV S  A  LT  DD   L+++AD  LY++K +GRN     R  
Sbjct: 439 DGHEFSVTASIGVASVEAGALTRDDD---LLIKADKALYKAKNNGRNMVVISRPE 490


>UniRef50_Q2VYV6 FOG: GGDEF domain n=2 Tax=Magnetospirillum RepID=Q2VYV6_MAGSA
          Length = 578

 Score =  251 bits (643), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 53/187 (28%), Positives = 90/187 (48%), Gaps = 7/187 (3%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLL 180
             I V   +     +  ++   A  D LT +++R    E  +     + +  + L  ++L
Sbjct: 395 GVIGVMLDITERKRMEAELRRLATTDVLTGIFNRRHFMEMARIEVDRARRHGRPLVALML 454

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DID+FK IND +GH  GD  +   A    +I+  + ++ RMGGEEFA+ +   +    LL
Sbjct: 455 DIDHFKRINDTHGHPVGDVAIKALADVCTQIIRHEDVLGRMGGEEFAIVLTETDLDGALL 514

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           +AE++R+ V       +  T+  T SIGV       L      + ++  AD  LY +K+ 
Sbjct: 515 VAERLRQAVAAIRIPAELGTVAFTTSIGVAER----LEGDATIDTILSRADMALYSAKRS 570

Query: 301 GRNRTST 307
           GRN+ + 
Sbjct: 571 GRNKVAV 577


>UniRef50_A1AK55 Diguanylate cyclase with PAS/PAC sensor n=2 Tax=Desulfuromonadales
           RepID=A1AK55_PELPD
          Length = 301

 Score =  251 bits (643), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 53/186 (28%), Positives = 90/186 (48%), Gaps = 8/186 (4%)

Query: 122 AICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVM 178
                ++   V  + +  +++      D LT VY+R  L   LK    +  +     ++M
Sbjct: 117 ITSLFLIVQDVTELATYEQKLIEMNTVDALTGVYNRRFLESRLKEECDRYGRYSRPFSLM 176

Query: 179 LLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDG 238
           ++DID+FK +ND +GH+ GD VL   A     ++     +AR GGEEF   +P  +    
Sbjct: 177 MIDIDFFKKVNDTHGHQGGDLVLKNVAAGAAAMIRKSDFLARYGGEEFCCLLPETDCDAA 236

Query: 239 LLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSK 298
             +AE +R  +E     +Q+K + +T+S+G+           D    L+  AD  LY++K
Sbjct: 237 ETVAEHLRAHIENMEHLFQKKVIRVTISLGIACFAP-----DDSPETLVKRADEALYQAK 291

Query: 299 KDGRNR 304
           + GRNR
Sbjct: 292 RSGRNR 297


>UniRef50_A5GCU4 Diguanylate cyclase n=2 Tax=Geobacter RepID=A5GCU4_GEOUR
          Length = 422

 Score =  251 bits (643), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 59/244 (24%), Positives = 114/244 (46%), Gaps = 12/244 (4%)

Query: 67  IWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPI 126
           + C      ++  ++  ++  + +V +        +    +        LGI       +
Sbjct: 187 LECHRSQGYKIGSVMGALSVTIPVVTLIRETDTDKLMIVAATIGTIGLLLGITYFLTWRL 246

Query: 127 MVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQ---TQHLTVMLLDID 183
           +++  +       K +   A  D LT + +R  + + L     +     + L +++LD+D
Sbjct: 247 VLNLDM-----AQKHLKRLASTDELTGLKNRRQIMKRLDEEYQRAIRLGEPLCLIMLDLD 301

Query: 184 YFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAE 243
           +FK IND YGH  GD VL   A H++K +    ++ R+GGEEF +  P     + +++A+
Sbjct: 302 HFKKINDTYGHPFGDLVLKCVAGHMKKALRRYDVLGRIGGEEFLIVSPGTTREEAVVLAQ 361

Query: 244 KIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           ++R  VE++   ++ K + +TVS GV           D+   L+  AD+ LY +K++GRN
Sbjct: 362 RLRSTVEMEKIAYEDKKVTITVSCGVAFLYKG----DDNVEILLKRADSALYIAKQEGRN 417

Query: 304 RTST 307
           R   
Sbjct: 418 RVVA 421


>UniRef50_Q47Y21 GGDEF domain protein n=1 Tax=Colwellia psychrerythraea 34H
           RepID=Q47Y21_COLP3
          Length = 722

 Score =  251 bits (642), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 69/283 (24%), Positives = 122/283 (43%), Gaps = 16/283 (5%)

Query: 32  FKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIV 91
            K E  +  +A+++ ++ ++    A  L + + + +        ++T  L  ++     +
Sbjct: 452 LKKEGYLIILAMLIFLLVAIFF--ALVLNYSIISPV-------RKLTYALNDMSEGQNNI 502

Query: 92  LVANSVIDISVGS-PFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDF 150
              +      +GS   +  ++    L               +    S        A  D 
Sbjct: 503 HFNHIDSKDEIGSMQLAFEKLRRKLLQGDVYKATVSQQQKEIKYRKSQQDHFQQLALTDA 562

Query: 151 LTQVYSRSGLYEALKSPSLK---QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARH 207
           LT   +R    E L             L++MLLDID+FKS+ND YGH  GD+VL +F + 
Sbjct: 563 LTGAVNRHHFNEVLDQEIANVNNHGSPLSIMLLDIDHFKSVNDRYGHGVGDEVLVMFYQT 622

Query: 208 IQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSI 267
             + V    +VAR+GGEEF + +P+   V+    AE++R+ +           + +TVSI
Sbjct: 623 CVEAVRSSDVVARIGGEEFVIIMPNTQLVNAQKFAERLRQKIAKLELNIANNQISVTVSI 682

Query: 268 GVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRY 310
           GV   ++ Y T  + F   +  AD  LY++K  GRN+    + 
Sbjct: 683 GVSQWQSEYFTNAETF---VAHADKSLYQAKNSGRNKVVVAQQ 722


>UniRef50_Q15V65 Diguanylate cyclase n=1 Tax=Pseudoalteromonas atlantica T6c
           RepID=Q15V65_PSEA6
          Length = 370

 Score =  251 bits (642), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 78/313 (24%), Positives = 136/313 (43%), Gaps = 20/313 (6%)

Query: 7   SEQFSTGV-LIVPCMLTLAIPGVLPRFK------AEQMMPAIALIVSVIASVVIGGAG-- 57
           ++ F  GV L+V   L      +L  F+          +   AL++ ++  +V GG    
Sbjct: 58  NDDFYLGVTLLVASALFFTSRLILKFFQSKNGYKVSANLVTGALMLLMLYLIVTGGVKNT 117

Query: 58  --SLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLV-ANSVIDISVGSPFSIPQMFSA 114
                + +P ++         +  L  F   A+ I+    N  +       FS   ++S 
Sbjct: 118 GPLWIYIVPPVVLFFGGLKRGLIQLGCFAFVAIVILEYPGNLFLMAQYSDEFSSRLIYSF 177

Query: 115 RLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQ 171
                           S   +  L ++   +A  D L+ + +R G+ E L+     +L+ 
Sbjct: 178 ITVSLLFVFYEYSRQRSFKTLQELSREFEKQARLDPLSGLQNRRGMLEKLEYEHQRTLRH 237

Query: 172 TQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVP 231
            ++LT+M+ DID+FK +ND +GH+ GD V++   +   K +  +  VAR GGEEF   +P
Sbjct: 238 HKNLTLMMCDIDHFKRVNDKFGHDVGDGVITQVGQLFDKALRKQDTVARWGGEEFLFLLP 297

Query: 232 SVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEAD 291
                    +AEK+R  V  Q +     +  +TVS+G+           D+ +  +  AD
Sbjct: 298 ETTQEQAFTLAEKLRAQVSKQQYQAGSDSFTVTVSLGIYQMHPQ-----DNLDHAISRAD 352

Query: 292 TCLYRSKKDGRNR 304
           T LYR+K +GRN 
Sbjct: 353 TNLYRAKSNGRNC 365


>UniRef50_Q47W79 GGDEF domain protein n=1 Tax=Colwellia psychrerythraea 34H
           RepID=Q47W79_COLP3
          Length = 334

 Score =  251 bits (641), Expect = 3e-65,   Method: Composition-based stats.
 Identities = 65/312 (20%), Positives = 137/312 (43%), Gaps = 19/312 (6%)

Query: 7   SEQFSTGVLIV---PCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASV--VIGGAGSLAF 61
           + Q +TGVL++     ++       +   K    +   ++  +        +    S   
Sbjct: 31  ANQLNTGVLVIDADFNIVIWNRFLQVHTDKVPGSIIGQSIFSAFPELPQRWLSRKLSSVL 90

Query: 62  PLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATM 121
            L    +C+ +    +  L        +   +A +   + + +  +          I  +
Sbjct: 91  QLNTPSFCSWQQRHHLFELPHTRPITTDSEFMAQNCTFLPIETDVNGK-------HICIL 143

Query: 122 AICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVM 178
                        +   + ++A  +  D LTQVY+R    ++L+     + +  + L+++
Sbjct: 144 IEDVTDACHYQMQLQKTLAEIAQISRIDGLTQVYNRRHWQDSLEQEYAKARRHDKKLSLI 203

Query: 179 LLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDG 238
           +LD+D+FK +NDNYGH+ GD VL   +  I  ++  +    R GGEEFA+ +P  +    
Sbjct: 204 MLDLDHFKLLNDNYGHQGGDMVLIEVSALISTLLRVEDTFGRYGGEEFAIILPETDSAGA 263

Query: 239 LLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSK 298
           + +A++I + +   PFT+  + + +TVS+GV    +       ++ +L+ +AD+ LY++K
Sbjct: 264 IELAQRICRIIATTPFTYNDQVIKVTVSLGVAQLSSKES----NYEELITQADSALYQAK 319

Query: 299 KDGRNRTSTMRY 310
             GRN+      
Sbjct: 320 SQGRNQVCNAAE 331


>UniRef50_Q1JXK3 Diguanylate cyclase n=1 Tax=Desulfuromonas acetoxidans DSM 684
           RepID=Q1JXK3_DESAC
          Length = 475

 Score =  251 bits (641), Expect = 3e-65,   Method: Composition-based stats.
 Identities = 61/221 (27%), Positives = 105/221 (47%), Gaps = 11/221 (4%)

Query: 91  VLVANSVIDISVGSPFSIPQMFSARLGI---ATMAICPIMVSFSVAAINSLMKQVALRAD 147
           ++ A S+ + +  + +    +     G+   A +    I+   S      + +Q+  +A 
Sbjct: 254 MIAAVSINEDNFFADWRRHSLLMGGFGLVVGAILFTLSILTVRSQQEQFRIQQQLQQQAT 313

Query: 148 FDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGHECGDKVLSVF 204
            D LT + +R    E       +  +    L+V+++DID+FK +ND YGH  GD+VL   
Sbjct: 314 TDPLTGIANRRYALEQAALEIKRNQRTGTPLSVVMMDIDHFKKVNDTYGHHVGDQVLMEV 373

Query: 205 ARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLT 264
           A+  +    +  LV+R GGEEF + +PS N       AEKIR+ +E   F   +  + +T
Sbjct: 374 AQTCRSHCRESDLVSRFGGEEFLILLPSTNLNGAQTHAEKIRQAIEDLSFPTAEGNVSVT 433

Query: 265 VSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
            S GV   +          ++++  AD  LY++K DGRN  
Sbjct: 434 ASFGVSQWQGETK-----IDRVVSRADAALYQAKHDGRNCV 469


>UniRef50_Q0EXC8 Signal transduction protein containing a membrane domain an EAL and
           a GGDEF domain-like n=1 Tax=Mariprofundus ferrooxydans
           PV-1 RepID=Q0EXC8_9PROT
          Length = 615

 Score =  250 bits (640), Expect = 4e-65,   Method: Composition-based stats.
 Identities = 53/184 (28%), Positives = 94/184 (51%), Gaps = 9/184 (4%)

Query: 128 VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDY 184
           +   +     L +++  +A  D LT + +R   +E  +    +  +H    ++++LD+D+
Sbjct: 431 IDRDITDRKELERELESQARTDVLTGLNNRRYFFELAELELARAKRHGNQFSLLMLDVDH 490

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEK 244
           FK  ND+YGH  GD+VL   +      + +  L  R+GGEEFA+ +P       + +AE+
Sbjct: 491 FKLFNDSYGHHIGDRVLQKLSEVCMHTLREIDLSGRIGGEEFAIMLPETRGDRAMEVAER 550

Query: 245 IRKGVELQPFTWQQKT--LYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           +R  +   P   +Q++  ++ TVSIGV S  A+        + L+  AD  LY +K  GR
Sbjct: 551 LRLAIAGAPVLLEQQSTFVHFTVSIGVTSLVAA----GRQVDDLLKRADDALYAAKNAGR 606

Query: 303 NRTS 306
           N+  
Sbjct: 607 NQVC 610


>UniRef50_A1U7E6 Diguanylate cyclase n=1 Tax=Marinobacter aquaeolei VT8
           RepID=A1U7E6_MARAV
          Length = 405

 Score =  250 bits (640), Expect = 4e-65,   Method: Composition-based stats.
 Identities = 78/317 (24%), Positives = 126/317 (39%), Gaps = 25/317 (7%)

Query: 5   WFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLP 64
           W S      +  +  + T  IP V  R +A  ++ A        A+ +IG  G       
Sbjct: 98  WLSTTLVLVLAALMYVYTFHIPDVNLRIQAFSIVFA--------AACLIGATG------- 142

Query: 65  ALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAIC 124
            L             L+          +         V     +   + + L I      
Sbjct: 143 FLRHRESHNRMAGKMLIAMFLLVSAFFIFRFFRSFYEVPPEDFMNAGWLSALAIVAGEFL 202

Query: 125 PIMVSFSV--AAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVML 179
            I+ SF     A + L  +++  A  D LT +Y+R    E       +  +      +++
Sbjct: 203 VILSSFCTIWMASDELQDELSEIARIDPLTGLYNRRAFDECCDIEFSRAQRSGAPFAIIM 262

Query: 180 LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGL 239
            D+D+FK +ND YGH  GD+VL  FA  +++ +    +VAR GGEEF + +P  +   GL
Sbjct: 263 CDLDHFKRVNDRYGHHVGDEVLRRFANTLKEHIRKHDVVARFGGEEFVLLLPGKDTEQGL 322

Query: 240 LMAEKIRKGVELQPFTWQQKT-LYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSK 298
            +AEK+R        T      L L+ S GV    +S       ++ ++  AD  LY +K
Sbjct: 323 EVAEKLRAKTADTQITIGDDVCLTLSASFGVAHYDSSDRE----WSAVLHRADNALYAAK 378

Query: 299 KDGRNRTSTMRYGEEVV 315
           K GRNR   +    + V
Sbjct: 379 KQGRNRVVDLGTENQSV 395


>UniRef50_D0SXM5 Predicted protein n=2 Tax=Acinetobacter lwoffii SH145
           RepID=D0SXM5_ACILW
          Length = 440

 Score =  250 bits (639), Expect = 5e-65,   Method: Composition-based stats.
 Identities = 77/294 (26%), Positives = 132/294 (44%), Gaps = 15/294 (5%)

Query: 25  IPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFV 84
           I  +     A   +  +AL +S   +  I    S  F L A +      T     +   +
Sbjct: 129 ILPIGTTVAAAAWIGLLALSISPHVATYI--YASAIFILIANL---CVQTQFKVAVYCSI 183

Query: 85  TGAVEIVLVANSVIDISVGSPFS--IPQMFSARLGIATMAICPIMVSFSVAAINSLMKQ- 141
             A+ I+L  +  +  S    FS     ++   + I    I  +  SF  + ++    Q 
Sbjct: 184 LIALFIMLGVSQFMSASQAFIFSVVFSPLWFFSIYINWNNILNVRRSFLRSLLDEWNYQT 243

Query: 142 VALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLT--VMLLDIDYFKSINDNYGHECGDK 199
           +   A  D LTQ+Y+R    +  +    +  +H +  +++ D+D+FK+IND+YGH+ GD+
Sbjct: 244 LKNLAHTDDLTQLYNRRHFVDMAERSIHQWPKHASSCLLMFDVDHFKNINDSYGHDVGDR 303

Query: 200 VLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ-Q 258
           VL + A   +K +    ++AR GGEEF   +      D L++AE+IR  ++ Q    +  
Sbjct: 304 VLQLIAEVTRKEMRHSDVLARFGGEEFIALLEDTQLQDSLVIAERIRCAIQKQYIYVEPN 363

Query: 259 KTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGE 312
            T+  T+SIGV    +           L+ +AD  LY++KK GRNR        
Sbjct: 364 HTIRFTISIGVAELESHTQP----LEDLIKQADIALYQAKKSGRNRIEVYHPDM 413


>UniRef50_B8DIJ3 Diguanylate cyclase with PAS/PAC and GAF sensors n=1
           Tax=Desulfovibrio vulgaris str. 'Miyazaki F'
           RepID=B8DIJ3_DESVM
          Length = 1000

 Score =  250 bits (639), Expect = 6e-65,   Method: Composition-based stats.
 Identities = 53/190 (27%), Positives = 92/190 (48%), Gaps = 7/190 (3%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVMLL 180
             + ++  +     L + +   A  D LT + +R   +   E     +++  + L V++L
Sbjct: 793 VVLSIARDITDRKRLEQALMREATTDPLTGIRNRRQFFVDAEREMGRAVRYGRPLAVLML 852

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           D+D FK +ND +GH  GD VL    +  Q+ + +  ++ R+GGEEFA  +   +  D L 
Sbjct: 853 DLDRFKRVNDRFGHHAGDAVLMGCVQACQQALRETDILGRLGGEEFAAVLLETDLDDALA 912

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
            AE++R+ VE     +  + L  TVSIG+              + ++  AD+ LY +K+ 
Sbjct: 913 AAERLRRAVEEMDVPFSGQRLRCTVSIGLALRGPG----DGALDDILRRADSALYAAKEA 968

Query: 301 GRNRTSTMRY 310
           GRNR    R 
Sbjct: 969 GRNRVMLARA 978


>UniRef50_B8FMG8 Diguanylate cyclase n=1 Tax=Desulfatibacillum alkenivorans AK-01
           RepID=B8FMG8_DESAA
          Length = 417

 Score =  250 bits (638), Expect = 6e-65,   Method: Composition-based stats.
 Identities = 65/208 (31%), Positives = 111/208 (53%), Gaps = 5/208 (2%)

Query: 108 IPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP 167
           I    +A + ++ +++  I+VS     +    + + + +  D LT++++R      L   
Sbjct: 209 IASGLTAAISLSLLSMIWILVSRLARRLTKAYETIEVMSITDELTRLHNRRHFETRLAEE 268

Query: 168 S---LKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGE 224
               L+    +++M+LDID+FK +NDNYGH+ GD VL+ FA  ++  V    + AR GGE
Sbjct: 269 ISRSLRYGSPMSLMILDIDHFKRVNDNYGHQAGDWVLTQFATLLKDNVRKADVPARWGGE 328

Query: 225 EFAVAVPSVNPVDGLLMAEKIRKGVELQPFTW-QQKTLYLTVSIGVGSGRA-SYLTLTDD 282
           EF V +         + AEK+R+ VE   F     +++ +TVS+GV S    S   +  +
Sbjct: 329 EFVVILTESTISQARMAAEKVRRNVESAEFNIPDGRSIPVTVSVGVASLDMISGDEMGSE 388

Query: 283 FNKLMVEADTCLYRSKKDGRNRTSTMRY 310
            + L+  AD  LYR+K++GRNRT  +  
Sbjct: 389 ADVLVKTADDALYRAKQEGRNRTVAVSS 416


>UniRef50_B7R5U6 PAS fold family protein n=13 Tax=Thermoanaerobacterales
           RepID=B7R5U6_9THEO
          Length = 692

 Score =  250 bits (638), Expect = 6e-65,   Method: Composition-based stats.
 Identities = 47/187 (25%), Positives = 87/187 (46%), Gaps = 11/187 (5%)

Query: 125 PIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLD 181
            I +   ++      + +  ++  D LT +Y+R    + L+    +  ++    ++++ D
Sbjct: 514 AIGIIRDISERKRFEELLYRQSITDPLTNIYNRRFFMQMLEQEIERVKRNKKLFSLIMFD 573

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           +D+FK++ND +GH  GD VL   A  ++  +      AR GGEEF + +P  +  +   +
Sbjct: 574 LDHFKNVNDRFGHAAGDMVLKSVADTVKGRIRKTDYFARWGGEEFIILLPETSLNNAAEL 633

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
           AE++RK +         K   +T S GV   R      TD  + +++  D  LY +K  G
Sbjct: 634 AEELRKKISETELDGIGK---VTASFGVTEYR-----NTDTVDTVLLRVDGALYEAKGSG 685

Query: 302 RNRTSTM 308
           RN     
Sbjct: 686 RNCVKIA 692


>UniRef50_A3WKT4 GGDEF domain protein n=2 Tax=Alteromonadales RepID=A3WKT4_9GAMM
          Length = 364

 Score =  250 bits (638), Expect = 6e-65,   Method: Composition-based stats.
 Identities = 86/326 (26%), Positives = 140/326 (42%), Gaps = 33/326 (10%)

Query: 14  VLIVPCMLTLAIP--------------GVLPRFKAEQMMPAIALIV------SVIASVVI 53
           V      L L  P                   F   + M AI+LI       S + +++I
Sbjct: 32  VAFFFIFLILNSPILAWVNLLSIAMYLTAYWAFGQRKNMLAISLIWLEVLYHSALGTLMI 91

Query: 54  GGAGSLAFPLPAL---IWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQ 110
           G      + L      I+ ++   P V  LL      + + L +     +   +  ++  
Sbjct: 92  GWDSGFHYFLLMFVPAIFVSMSLKPAVLTLLGLWVYYLSLDLFSWYYPAMQPINATAVVG 151

Query: 111 MFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLK 170
           +    L +  +    + + + +  +N    Q+   A  D LT++ +R  + E LK     
Sbjct: 152 VHIFNLTVVFIMFGYLAL-YYLNKVNLTHDQLRFYATTDPLTKLRNRRHMSELLKRALQN 210

Query: 171 ---QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFA 227
              + ++++V+LLD+D+FKS+ND +GHE GDKVL + A  ++  V D   V+R GGEEF 
Sbjct: 211 KHAEQRNVSVLLLDLDHFKSVNDTHGHEVGDKVLRITADILRDTVRDHDKVSRWGGEEFL 270

Query: 228 VAVPSVNPVDGLLMAEKIRKGVELQPFTWQ-QKTLYLTVSIGVGSGRASYLTLTDDFNKL 286
           V +P  N      +AE+IRK +   P+     + + LT SIGV   +       D  N L
Sbjct: 271 VFLPRTNLNHAAQVAERIRKAIAKYPWHTVINENIQLTTSIGVSELKP-----DDSVNTL 325

Query: 287 MVEADTCLYRSKKDGRNRTSTMRYGE 312
           +  AD  LYR K+ GRN         
Sbjct: 326 VKRADDALYRGKEAGRNWVELESEAS 351


>UniRef50_D0KF92 Diguanylate cyclase n=1 Tax=Pectobacterium wasabiae WPP163
           RepID=D0KF92_PECWW
          Length = 489

 Score =  250 bits (638), Expect = 7e-65,   Method: Composition-based stats.
 Identities = 82/315 (26%), Positives = 148/315 (46%), Gaps = 17/315 (5%)

Query: 5   WFSEQFSTGVLIVPCMLTLA--IPGVLPRFKAEQMM----PAIALIVSVIASVVIGGAGS 58
           WFSE+ S+GV+ V   L +   I  VL   +    M    P   L   +I   +     +
Sbjct: 164 WFSEELSSGVIFVFLFLNITKKIKNVLKISQISIKMTIKKPFFILYPLIIIFCIASSNIT 223

Query: 59  L-AFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDIS--VGSPFSIPQMFSAR 115
           L    +  LI+ ++  +     ++   TG     +  N +I +   +   +     +  +
Sbjct: 224 LSVLAILPLIYLSLSLSFNKIVVMCSATGIALNYIYINRLIGVHNKIEKEYLFELSYLFQ 283

Query: 116 LGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKS--PSLKQTQ 173
           +  + + I  +  SF +      +K++ L ++ D LT + +R  L + + +   S++  +
Sbjct: 284 INTSVIIITALTASFFINGNRKNIKRIELISNHDALTGMLNRRSLNQHMMNIINSIRDGE 343

Query: 174 H--LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVP 231
           +  +++++LDID+FK IND YGH  GD V+  F+  I++    + L+ R GGEEF + + 
Sbjct: 344 NKMMSLLVLDIDHFKKINDTYGHAVGDNVIRGFSTAIKQHTRPQDLLCRWGGEEFLIIIQ 403

Query: 232 SVNPVDGLLMAEKIRKGVELQPFTW-QQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEA 290
            ++  + L +AE+IR  +E           +  T SIGV       L   +DF+    EA
Sbjct: 404 GLSKNECLEIAERIRTIIEGSSLAISNGHAVRCTTSIGVSFFH---LERIEDFHDAFKEA 460

Query: 291 DTCLYRSKKDGRNRT 305
           D  LY +K+ GRNR 
Sbjct: 461 DKLLYIAKEQGRNRV 475


>UniRef50_Q085X7 Diguanylate cyclase n=2 Tax=Alteromonadales RepID=Q085X7_SHEFN
          Length = 357

 Score =  250 bits (638), Expect = 7e-65,   Method: Composition-based stats.
 Identities = 72/305 (23%), Positives = 127/305 (41%), Gaps = 18/305 (5%)

Query: 10  FSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWC 69
           F + ++     L   +     +      +   +L + +   V  GG      PL   I  
Sbjct: 52  FVSSIIYC---LAYIVLKKYNKLNLSSFIIIYSLYILMFYLVFTGGVEQ-TGPLWIFIVA 107

Query: 70  AVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVS 129
            V                   ++       I +    +    F  RL ++ +    +   
Sbjct: 108 PVSVYVLGLSYGLVNLLFFLSIIAIIMFSPIEMPQYATYSTEFKVRLILSFLTTTFLSAL 167

Query: 130 FSVAAINSLM------KQVALRADFDFLTQVYSRS---GLYEALKSPSLKQTQHLTVMLL 180
           +  + + S        K+    A  D LT + +R     + +  KS   +  + L+V+L 
Sbjct: 168 YEYSRMLSYNSALKLGKKYQQLALSDPLTTLANRRNALTILQQEKSRISRNNEPLSVLLC 227

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           D+D+FK +ND YGH CGD VL+  ++  ++ V  +  VAR GGEEF   +P  +     +
Sbjct: 228 DLDHFKMVNDKYGHNCGDMVLTELSQVFKQSVRQQDCVARWGGEEFLFILPQTSAEQASV 287

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           +AEKIR  V      + +  + LT+SIG+        T   + ++L+  AD  LY++KK+
Sbjct: 288 IAEKIRTNVHHHKVHFLKHEISLTISIGISQL-----TDDQNIDELINNADRNLYQAKKN 342

Query: 301 GRNRT 305
           GRN+ 
Sbjct: 343 GRNQV 347


>UniRef50_A6DDS7 Diguanylate cyclase (GGDEF domain) n=1 Tax=Caminibacter
           mediatlanticus TB-2 RepID=A6DDS7_9PROT
          Length = 750

 Score =  250 bits (638), Expect = 7e-65,   Method: Composition-based stats.
 Identities = 62/182 (34%), Positives = 95/182 (52%), Gaps = 12/182 (6%)

Query: 130 FSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKS---PSLKQTQHLTVMLLDIDYFK 186
           + ++ I  L KQ+   A +D LT +Y+R+     LK     S +    L+++ LDIDYFK
Sbjct: 578 YQLSKIKKLSKQLETMAFYDKLTNIYNRAKFKNILKEFIEYSKRYKTPLSLIFLDIDYFK 637

Query: 187 SINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIR 246
            INDN+GHE GD VL    +  +  + +  +  R GGEEF + +P+ +     ++AEKIR
Sbjct: 638 KINDNFGHEKGDLVLKEMVKVAKLSLRESDVFGRWGGEEFLILLPNTDINGAKIVAEKIR 697

Query: 247 KGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
             +E   F      + +TVS+GV   +       D     +  AD  LY++KK+GRNR  
Sbjct: 698 DAIESHDF----DGIKVTVSLGVTQLK-----EDDTIESFVNRADIALYQAKKEGRNRVV 748

Query: 307 TM 308
             
Sbjct: 749 VF 750


>UniRef50_C0QM24 Putative uncharacterized protein n=1 Tax=Desulfobacterium
           autotrophicum HRM2 RepID=C0QM24_DESAH
          Length = 488

 Score =  249 bits (637), Expect = 7e-65,   Method: Composition-based stats.
 Identities = 54/193 (27%), Positives = 91/193 (47%), Gaps = 8/193 (4%)

Query: 118 IATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQH 174
           + +  I  +++  +   I S  K++   A  D LT VY+R       +       ++   
Sbjct: 291 VFSFGIIGLILIVTNLTIASFQKRLTKMASTDKLTGVYNRRAFDIIIDQTLKEIQRKQTP 350

Query: 175 LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVN 234
           L+++L D+D+FK +ND YGH  GD ++        + + +  ++ R GGEEF + +   +
Sbjct: 351 LSIILFDLDHFKRVNDTYGHLAGDYIIQTTVGTAARTIRNSDILCRWGGEEFLILLKGCD 410

Query: 235 PVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCL 294
             D +  AEKIR  V  QP  +    + +T+S+GV           D    L+  AD  L
Sbjct: 411 LGDAMKTAEKIRTAVASQPARYGDDQICVTISVGVTEHTGQ-----DTKETLLKRADKAL 465

Query: 295 YRSKKDGRNRTST 307
           Y +K  G+NR  T
Sbjct: 466 YLAKASGKNRCET 478


>UniRef50_C4XS30 GGDEF domain protein n=1 Tax=Desulfovibrio magneticus RS-1
           RepID=C4XS30_DESMR
          Length = 498

 Score =  249 bits (637), Expect = 8e-65,   Method: Composition-based stats.
 Identities = 58/170 (34%), Positives = 91/170 (53%), Gaps = 6/170 (3%)

Query: 141 QVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECG 197
           QV +RAD D LT++++R    E L     +  ++   ++++++DID+FK IND YGH  G
Sbjct: 314 QVKIRADHDGLTRIHNRRAFDERLIDELRRHQRYRHAMSLLMVDIDHFKGINDRYGHLVG 373

Query: 198 DKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ 257
           D VL      + + +      AR GGEEF V +P        ++AE++R  +    F   
Sbjct: 374 DHVLREVGSILSETLRSTDFTARYGGEEFVVILPQTAEEQARILAERLRGAIAEARFVHD 433

Query: 258 QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
            +   +TVSIGV + +   LT   D   L+ +AD  LY++K  GRN+  T
Sbjct: 434 GEDFSITVSIGVSALQPGALTRRKD---LLEKADKALYQAKHLGRNQVCT 480


>UniRef50_A8TM57 Putative diguanylate cyclase (GGDEF domain) with PAS/PAC sensor
           domain n=1 Tax=alpha proteobacterium BAL199
           RepID=A8TM57_9PROT
          Length = 461

 Score =  249 bits (636), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 55/191 (28%), Positives = 91/191 (47%), Gaps = 7/191 (3%)

Query: 122 AICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVM 178
            I    V   V   + L +++   A  D LT + +R       +     +++  + ++V+
Sbjct: 273 LIGVTGVMVDVTESHRLRQELERLATTDPLTGLSNRRAFLMRAREEVERAVRHDRPMSVV 332

Query: 179 LLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDK-GLVARMGGEEFAVAVPSVNPVD 237
           ++D+D+FKS+ND YGH+ GD VL   A  +Q  + +   + AR GGEEF + +P      
Sbjct: 333 MIDVDHFKSVNDRYGHDIGDLVLQDVAATVQGALRNSGDVAARFGGEEFVLLLPETTVSG 392

Query: 238 GLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRS 297
              +AE+IR   E      +Q  +  T S GV   R+         + ++  AD  LYR+
Sbjct: 393 AQQLAERIRVAFERTAVETEQGAVRFTASFGVDVFRSDM---DTGIDTVLKRADDALYRA 449

Query: 298 KKDGRNRTSTM 308
           K+ GRNR    
Sbjct: 450 KEAGRNRVQLA 460


>UniRef50_B8GRD6 Diguanylate cyclase n=1 Tax=Thioalkalivibrio sp. HL-EbGR7
           RepID=B8GRD6_THISH
          Length = 464

 Score =  249 bits (636), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 78/310 (25%), Positives = 128/310 (41%), Gaps = 20/310 (6%)

Query: 15  LIVPCMLTLAIPGVLPRFKAEQMMPAIAL--IVSVIASVVIGGAGSLAFPLPA--LIWCA 70
           + +  M   A  G LP  +A  ++  +    ++  +A +++        PL    ++  A
Sbjct: 159 VFMLIMGIAAYLGQLPWAQARPVLVGLETGAMLLSLAGILVMAVLRTRSPLMTVYMVSLA 218

Query: 71  VRYTPQVTCLLT-----FVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLG----IATM 121
           V     +  LL             I      ++   +   F   + FS        +A +
Sbjct: 219 VFAQASLAFLLATPWNHLWWLGHGIFAAGFFMLSYGIVQAFHTTRSFSTVYSQMDMMAQL 278

Query: 122 AICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVM 178
                    ++  +    +++   A  D LT V +R  L E        S +    L+++
Sbjct: 279 REQQAWTQEALLQVQEANRKLEQLASTDALTGVANRRQLVERADMEVPRSERHGAPLSLL 338

Query: 179 LLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDG 238
            LD+D+FK IND+YGH  GD+VL   A  IQ+ +    L+AR+GGEEF V +P  +    
Sbjct: 339 CLDLDHFKRINDDYGHLAGDEVLKQVAEAIQQSLRPSDLLARVGGEEFHVLLPDTDLAGA 398

Query: 239 LLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSK 298
             +AE+IR  +E      Q   L++TVS+G             D   L   AD  LY++K
Sbjct: 399 RDVAERIRVKLEGLDIPVQGVVLHVTVSVGCAQLGP----DGADMKSLTHTADERLYQAK 454

Query: 299 KDGRNRTSTM 308
             GRNR    
Sbjct: 455 ALGRNRVVIA 464


>UniRef50_A1U4U5 Diguanylate cyclase n=2 Tax=Marinobacter RepID=A1U4U5_MARAV
          Length = 571

 Score =  248 bits (635), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 78/319 (24%), Positives = 130/319 (40%), Gaps = 26/319 (8%)

Query: 10  FSTGVLIVPCMLTLAIPGVLPRFKAEQM-------MPAIALIVSVIASVVIGGAGSLAFP 62
            +  ++ +P  L L +  +    +  +        M A+ ++  V     I  A   A  
Sbjct: 245 LNLSLITMPIFLLLFMMAIFETHEYFRTEHRVLQGMLALLVVTFVYGLFDIATALKPASS 304

Query: 63  LPAL-----IWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLG 117
           L AL        ++    +   L+ F        +V N    +          + S  +G
Sbjct: 305 LAALMMVVTFSVSISLFRKGHPLVKFFLVGHTFFVVFNGFAVLYYKGLVQPNYINSHGVG 364

Query: 118 I------ATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPS 168
           I       T+A         +  I S   ++  +A  D LT++++R       E +   +
Sbjct: 365 IGIVLEALTLAFIISYRIKVLEDIRSKQDELKRQASTDPLTRLFNRRYFMAEGEYVLEQA 424

Query: 169 LKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAV 228
               + L+V+ +DID+FK++ND +GH  GD VL   A   ++   D+ LVAR GGEEF +
Sbjct: 425 RTSGEPLSVIAIDIDHFKAVNDTHGHNVGDLVLVEVASVFRQFSRDRDLVARFGGEEFVI 484

Query: 229 AVPSVNPVDGLLMAEKIRKGVELQPFTWQQK-TLYLTVSIGVGSGRASYLTLTDDFNKLM 287
            +P  +  +G   AE+IR  VE           + +TVS+GV         L +     +
Sbjct: 485 LLPGADLTEGFGCAERIRNAVEAMVIDGGDGLAVRVTVSVGVAEVNP----LLESVEGAV 540

Query: 288 VEADTCLYRSKKDGRNRTS 306
             AD  LY +K  GRNR  
Sbjct: 541 KRADRSLYEAKAGGRNRVC 559


>UniRef50_C9YC42 Putative uncharacterized protein n=1 Tax=Curvibacter putative
           symbiont of Hydra magnipapillata RepID=C9YC42_9BURK
          Length = 409

 Score =  248 bits (635), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 74/316 (23%), Positives = 138/316 (43%), Gaps = 25/316 (7%)

Query: 12  TGVLIVPCMLTLAIPGVLPRFKAEQ--MMPAIALIVSVIASVVIGGAGSLAFPLPALIWC 69
           TG+     +   A   +  R ++     +P +A+ V ++ +++I        P     + 
Sbjct: 96  TGMGAAFALCAWACRPLEHRHRSWSGRWLPVLAMAVCIVFAMLITAIDQWVTPAITPFFI 155

Query: 70  AVRYTPQVTCLLTFVTGAV--EIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIM 127
           A   T     L   V  A+     ++ +++I ++  +P  +       L +  +  C  +
Sbjct: 156 ACIVTSLTIYLRPHVAAALFGVAFVLFSTLIGMTQHNPEMLLSNRINGLAVCVIGFCLSV 215

Query: 128 VSFS---------------VAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQT 172
           + +                   +    +++      D LT +++R+   E   +   +  
Sbjct: 216 LMWRKFTTIAVQKHQLEKAHTELQLKQRELERLTRQDGLTGLFNRNTFVELSTNELKRAK 275

Query: 173 QHLT---VMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVA 229
           +  +   ++LLD+D+FK IND +GH  GD VL   A+ +   V    LV R+GGEEF V 
Sbjct: 276 RQGSATTILLLDLDHFKRINDTWGHPAGDVVLRHVAQTMVNSVRSTDLVGRLGGEEFIVL 335

Query: 230 VPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVE 289
           +P         +AEKIR+ +E+    W+ K + +T SIG+     +    + +F+ L  E
Sbjct: 336 LPHTTAEASRKIAEKIRQRLEVSDIRWEGKRIAVTASIGLS---GTTAEESREFDSLYTE 392

Query: 290 ADTCLYRSKKDGRNRT 305
           AD  LY +K+ GRNR 
Sbjct: 393 ADKALYLAKQRGRNRV 408


>UniRef50_Q2SME0 Response regulator containing a CheY-like receiver domain and a
           GGDEF domain n=1 Tax=Hahella chejuensis KCTC 2396
           RepID=Q2SME0_HAHCH
          Length = 427

 Score =  248 bits (635), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 71/274 (25%), Positives = 128/274 (46%), Gaps = 15/274 (5%)

Query: 41  IALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVE--IVLVANSVI 98
           +A + ++  +++    G++ F +P  IW   R    +  L + V    E           
Sbjct: 159 LAYLHTLRETLLFSALGAIVFIIPFGIWEGSRLVRTLNHLTSAVNRMAEGEFKQQVPVKS 218

Query: 99  DISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRS 158
           +  VG+      + + +L  A   +       S   I    +Q+   +  D LT +Y+R 
Sbjct: 219 EDEVGALAKAFNLMNTQLHEAYKNL-----EDSRNKIAKQAEQLKELSIRDELTGLYNRR 273

Query: 159 GLYEA---LKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDK 215
              E    L + +L+      ++L DID+FK IND Y H  GD+VL   A+ +   + + 
Sbjct: 274 FFNEEVKVLHANALRYGNGFCLVLGDIDFFKRINDGYSHVVGDEVLKQVAKILMNSIRNS 333

Query: 216 GLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRAS 275
            +VAR GGEE  +A+P+ +P   + M E+IRK +E  P+    + + +T+S G+      
Sbjct: 334 DIVARYGGEEMVLALPNTSPQAAMEMMERIRKTIEQHPWDSIAEGMKVTMSFGI-----C 388

Query: 276 YLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
             T  + F  ++  AD  LY++K +GRN+  ++ 
Sbjct: 389 DETNGEHFEHMLAVADELLYKAKNNGRNQVCSLS 422


>UniRef50_C7R6Y0 Diguanylate cyclase n=1 Tax=Kangiella koreensis DSM 16069
           RepID=C7R6Y0_KANKD
          Length = 469

 Score =  248 bits (635), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 71/296 (23%), Positives = 136/296 (45%), Gaps = 18/296 (6%)

Query: 30  PRFKAEQMMPAIALIVSVIASVV--IGGAGSLAFPLPALIWCAVRYTPQVT-------CL 80
                 + +     + +V+  +V  I G   L + + A+IW A+                
Sbjct: 177 WWRLLTEYLSISLFLGAVLWMLVQNIRGYMPLQYGI-AMIWFALSCLSFSIGTVWDHQWW 235

Query: 81  LTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMK 140
           L  +  A   +L++  V+   + +  S   ++S       +         ++  + ++ +
Sbjct: 236 LAHIIFASGFLLLSFGVVQAFLTT-GSFKTIYSQTELFQQIIREKKKSERALIELKAVNQ 294

Query: 141 QVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECG 197
           ++   A  D LT+V +R    +  +    + +++   L +M++D D+FK IND YGH+ G
Sbjct: 295 KLEELAATDSLTRVANRREFMKRSEEEMSRSSRNSTDLCLMVIDFDHFKEINDQYGHQAG 354

Query: 198 DKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ 257
           DKVL  F +  ++++    L+ R+GGEEFA+ +P  N    + +AE++R+ +E +     
Sbjct: 355 DKVLKDFVKLAKEVMRPSDLLGRIGGEEFALLLPETNIRSAVKVAERLRQHIEEESIVIG 414

Query: 258 QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEE 313
            K + LT+SIGV   +       D   K +  AD  LY++K  GRNR     +  +
Sbjct: 415 SKRIKLTISIGVAEYQP----KVDTVKKWLHRADEFLYQAKDKGRNRVVVEAFDAD 466


>UniRef50_C4XPG9 GGDEF domain protein n=1 Tax=Desulfovibrio magneticus RS-1
           RepID=C4XPG9_DESMR
          Length = 368

 Score =  248 bits (634), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 57/191 (29%), Positives = 98/191 (51%), Gaps = 6/191 (3%)

Query: 125 PIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYE---ALKSPSLKQTQHLTVMLLD 181
            + ++  ++A  +L +++   A  D LT + +R G +E    +   + +    L++++LD
Sbjct: 175 VVGMTQDISARKALEEELLRLAASDPLTGLANRRGFFEGAARMLGMARRCGTPLSMIMLD 234

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           ID+FK++ND YGH+ GD VL   A  +++ +    L  R+GGEEFAV  P  +   G+ +
Sbjct: 235 IDHFKAVNDAYGHDAGDAVLRAVAGRLRESLRVSDLAGRVGGEEFAVLCPGTDLAGGVEL 294

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
           AE++R  +E    T   + + +T S GV   R          +  +  AD  LY +K+ G
Sbjct: 295 AERLRLALEDMVVTADCRAVKVTASFGVAQCRDD---RDAAPSACLTRADRALYAAKRGG 351

Query: 302 RNRTSTMRYGE 312
           RNR      G 
Sbjct: 352 RNRVCLESDGS 362


>UniRef50_Q3IJX5 Putative uncharacterized protein n=2 Tax=Alteromonadales
           RepID=Q3IJX5_PSEHT
          Length = 621

 Score =  248 bits (634), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 73/323 (22%), Positives = 125/323 (38%), Gaps = 31/323 (9%)

Query: 10  FSTGVLIVPCMLTLAI-------------------PGVLPRFKAEQMMPAIALIVSVIAS 50
           F T V+ + C++T  I                   P           + AI   +  ++ 
Sbjct: 290 FPTLVVTLFCLITTPIVLGYYVVTTLLCIRQNPSEPQKALLLALCSFLAAIVYFIITVSG 349

Query: 51  VVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFV----TGAVEIVLVANSVIDISVGSPF 106
           + I     +AF     + CA      V  L            + ++  ++  D  +    
Sbjct: 350 LYIFTNSRVAFVFICSLSCAFSLGYAVMKLFILQRDEQVTTQQTLIAKSAAQDALLHERL 409

Query: 107 SIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKS 166
           S+ +     L           +  ++  +    +++      D LT + +R    + L  
Sbjct: 410 SLQESVRQELETQVDERTF-ELQVTLRELEEKNRELEQLNMEDPLTGIKNRRFFDKKLVM 468

Query: 167 PSLKQTQ---HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIV-GDKGLVARMG 222
              +  +    L+V++LDID FK IND YGH  GD+V+   A  I+K +      VAR G
Sbjct: 469 ELRRSRREQTPLSVIMLDIDKFKVINDTYGHLTGDQVIRTAADTIKKQLQRPLDEVARYG 528

Query: 223 GEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDD 282
           GEEF V +P+      + +AEKIR  +          T+  T+S GV +  A  +   ++
Sbjct: 529 GEEFVVLLPNTQNDGAIAIAEKIRHAIATNNVHVAGTTISFTISAGVYTSVAEDI---NN 585

Query: 283 FNKLMVEADTCLYRSKKDGRNRT 305
                  AD  LY +K+ GRN+ 
Sbjct: 586 PEIFTERADKALYFAKQHGRNQV 608


>UniRef50_Q30WV4 Diguanylate cyclase (GGDEF domain) with PAS/PAC sensor n=1
           Tax=Desulfovibrio desulfuricans subsp. desulfuricans
           str. G20 RepID=Q30WV4_DESDG
          Length = 398

 Score =  248 bits (634), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 55/206 (26%), Positives = 97/206 (47%), Gaps = 21/206 (10%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLK---QTQHLTVMLL 180
             + V   V A   ++++++  A  D LT + +R    EA ++   +     + L++++L
Sbjct: 183 THVGVVLDVTAHRRMLEELSHMARTDPLTGLNNRRFFMEAARAEVERMQSSGRPLSLLML 242

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DID+FK +ND +GH+ GD VL   +  + + +  + + AR+GGEEFAV +P     +   
Sbjct: 243 DIDHFKRVNDTWGHDAGDMVLKQLSCCLAETMRGQDVCARLGGEEFAVLLPETGHAEACR 302

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTL----------------TDDFN 284
            AE +R+ V    F        +T S+G+ +  ++   +                     
Sbjct: 303 AAETLRQAVAGMAFA--GHGFSVTSSLGLTTLDSAGHAVSGQRPVPGGVAVSACCGQVVE 360

Query: 285 KLMVEADTCLYRSKKDGRNRTSTMRY 310
            L+  AD  LY +KK+GRNRT     
Sbjct: 361 ILLKRADIALYAAKKNGRNRTEVYPA 386


>UniRef50_C7LRA7 Diguanylate cyclase n=1 Tax=Desulfomicrobium baculatum DSM 4028
           RepID=C7LRA7_DESBD
          Length = 495

 Score =  248 bits (634), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 63/230 (27%), Positives = 104/230 (45%), Gaps = 12/230 (5%)

Query: 91  VLVANSVIDISVGSPFSIPQMF----SARLGIATMAICPIMVSFSVAAINSLMKQVALRA 146
           +L   S     V  P+    M     S  L +    +  ++V   +  +N   +++AL A
Sbjct: 270 LLAFASFPREMVLEPWKNHAMVYGGASIVLVLVVAGLSTLLVRGQI-RLNRQSRELALAA 328

Query: 147 DFDFLTQVYSRSGLYEALKSPSLK---QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV 203
             D LT   +R    E+      +      HL+ +++D+D+FK++ND YGH  GD VLS 
Sbjct: 329 STDMLTGALNRRAFMESASREFARVCRYGGHLSCIMIDLDHFKNVNDTYGHAAGDLVLSS 388

Query: 204 FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL 263
            A +I   + +  +  R GGEEF + +P  +      +AE++R G+         + L L
Sbjct: 389 SAHYIASRLREPDMFCRYGGEEFVILLPGTDRNGAATVAEELRAGLAGLDLQRGDEKLPL 448

Query: 264 TVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEE 313
           T S GV    A         + L+  AD  LY +K++GRNR       ++
Sbjct: 449 TASFGVAEIHAQCA----TLDTLLSLADQALYEAKENGRNRVCLAPRQQQ 494


>UniRef50_C8WZ84 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8WZ84_DESRD
          Length = 550

 Score =  248 bits (634), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 51/185 (27%), Positives = 86/185 (46%), Gaps = 7/185 (3%)

Query: 125 PIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLD 181
            + +   +       + +   +  D LT +++R      +     +  +    LT+ +LD
Sbjct: 357 VMAMVNDITHQQQYQEHLKRLSRTDELTGLFNRRHFITLMHKEFSRARRTHERLTLAMLD 416

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           ID+FK +ND YGH+ GD VL    R +++ V    + AR GGEEFA+  P  +      +
Sbjct: 417 IDHFKDVNDKYGHDVGDHVLQHLGRILREDVRPYDIAARYGGEEFAICFPDTDLSQADHI 476

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
            E++R        +    T+  TVS G+   R  +    +D + L+  AD  LY +K +G
Sbjct: 477 CERLRTLCAASEVSRNGGTIGFTVSFGLSELRPEH----EDLDGLLKSADNALYAAKANG 532

Query: 302 RNRTS 306
           RNR  
Sbjct: 533 RNRIE 537


>UniRef50_A3WKY5 Signaling protein with a ligand-binding sensor domain and GGDEF
           domain n=2 Tax=Idiomarina RepID=A3WKY5_9GAMM
          Length = 999

 Score =  248 bits (634), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 65/211 (30%), Positives = 101/211 (47%), Gaps = 15/211 (7%)

Query: 108 IPQMFSARLGIATMAICPIMVSFSVAAINSLM-------KQVALRADFDFLTQVYSRSGL 160
                   LG+A   +    + F       L        K++   A  D LTQ+ +R   
Sbjct: 794 FWLSIIFALGLAATILVRARIRFLNNQRAQLELMVAEKTKELKGLARQDSLTQLGNRRAF 853

Query: 161 YEALK---SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGL 217
            E L+       +  Q L++ ++D+D+FKSIND + H  GD+VL   +  +  ++ D   
Sbjct: 854 DEQLQYEFKRCERSEQPLSLAIIDVDHFKSINDRFLHVIGDQVLIELSALLSNMLRDIDY 913

Query: 218 VARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYL 277
           +AR GGEEFA+ +P     + L  AE+IR+ +E   +      L +TVSIGV S      
Sbjct: 914 IARWGGEEFALLMPETTAKEALQAAERIRQRIEDTSYQHLADELAVTVSIGVASS----- 968

Query: 278 TLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
               + + L+V AD  LY++K+ GRNRT   
Sbjct: 969 EHYPNHSALLVAADKALYKAKQSGRNRTELA 999


>UniRef50_A1WM32 Diguanylate cyclase n=2 Tax=Burkholderiales RepID=A1WM32_VEREI
          Length = 612

 Score =  248 bits (634), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 74/294 (25%), Positives = 119/294 (40%), Gaps = 10/294 (3%)

Query: 17  VPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQ 76
            P +L      + P ++A +    +A + S+  S       S   P     + A  +   
Sbjct: 320 APLILAAGFLALRPGYRAARFF-VLAFVASITGSFFTALTVSGLIPYTFANFHASEFGLL 378

Query: 77  VTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAIN 136
              +L     A  + L++    D +           +A L  A   +   MV    + + 
Sbjct: 379 ADMVLLSQALADRVKLLSEQR-DAAELREIEQKIATTALLKQANEDLER-MVLERTSELA 436

Query: 137 SLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYG 193
               +    A  D LT V +R    E       +  +    L+V+L+DID FK +ND YG
Sbjct: 437 RARDEAEHFARIDMLTGVANRRYFEEVATMEFARTQRGQQALSVILIDIDLFKQVNDRYG 496

Query: 194 HECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP 253
           H  GD V+   AR  ++ V +   VAR+GGEEF+V +P +        AE++R+ +    
Sbjct: 497 HAAGDAVIRAVARLAKESVRESDFVARIGGEEFSVLLPGIGQAPAFATAERLRERIAACV 556

Query: 254 FTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
                 +L  T S GV    A        F+ L+  AD  LY +K+ GRN+   
Sbjct: 557 VEHDGHSLGFTASFGVSEQVADDPG----FSSLLRRADQALYAAKQAGRNQVVV 606


>UniRef50_C7LVZ4 Diguanylate cyclase n=1 Tax=Desulfomicrobium baculatum DSM 4028
           RepID=C7LVZ4_DESBD
          Length = 483

 Score =  248 bits (634), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 77/293 (26%), Positives = 131/293 (44%), Gaps = 18/293 (6%)

Query: 23  LAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLT 82
           L +PG LP  +  + +  +  + + +    + G    A  L     C     P++  L+T
Sbjct: 201 LFLPGTLPHAQQAEWINHLLSVAARLGKQEVRGYQVSALELKD---CKPGNPPELEELIT 257

Query: 83  FVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQV 142
                  + L +     + + S     ++   RL I + A   + ++          ++ 
Sbjct: 258 L-----PLTLGSEPFGALVICSQ-DASKLGQDRLRILSSAANHLALA---MRNGLEFRKT 308

Query: 143 ALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDK 199
             RAD D LT++ +R      L+    +  +H   L++M++D+DYFKSIND YGH+ GD 
Sbjct: 309 KARADHDGLTRISNRHHFDIRLREEMKRHQRHQDELSLMMIDLDYFKSINDTYGHQAGDM 368

Query: 200 VLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQK 259
           VL    + +   + +    AR GGEEF V +P        ++AE++R  +    F  Q+K
Sbjct: 369 VLQEVGKILNNTLRESDFPARYGGEEFVVILPQTREDQAWILAERLRSQIGQTFFRSQKK 428

Query: 260 TLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGE 312
              +T SIG+   +   LT       L+  ADT LY++K +GRN        E
Sbjct: 429 RFRVTASIGIAGIKPCALTP---PETLLRNADTALYQAKTNGRNMVCCSAIEE 478


>UniRef50_Q1N3P2 Probable two-component response regulator n=1 Tax=Bermanella
           marisrubri RepID=Q1N3P2_9GAMM
          Length = 364

 Score =  248 bits (633), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 76/327 (23%), Positives = 128/327 (39%), Gaps = 24/327 (7%)

Query: 6   FSEQFST-GVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLP 64
           FS  FST  ++     L   I                  +++ I S  +     L   +P
Sbjct: 34  FSYTFSTLFIVTSILRLAHGILTQPFYAANPNAWRMTMYVLAFIHSCTLALLFILVLIIP 93

Query: 65  ALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAIC 124
                A+     V  LL+  + ++    +       S+  P ++           +    
Sbjct: 94  EYRDLAMAVALIVVGLLSGASASLSPKPIFTQFYIGSLAFPATLVSFLVEEFRFLSPLFA 153

Query: 125 PIMVSFSV----------------AAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP- 167
              + F                    +     ++    + D LT +Y+R     AL    
Sbjct: 154 ATWIYFIFLGRRFYNEYQRAFHIEMRLKENQVKLERLNETDTLTGIYNRQYFDNALDMQW 213

Query: 168 --SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVG-DKGLVARMGGE 224
             + +    L+++ LD+D+FK INDN+GH  GD+VL   A    +I      ++AR GGE
Sbjct: 214 DLASRSENSLSILFLDLDHFKKINDNFGHLAGDQVLCHAAHLFSEIARRKTDMIARYGGE 273

Query: 225 EFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFN 284
           EFA+ +P+    D L +AE+IR  +E  P    Q  ++LTVSIGV    +   +      
Sbjct: 274 EFAIILPATEKQDALDLAEQIRHAIENTPCRSDQGLIHLTVSIGV---NSVVPSPQGSPV 330

Query: 285 KLMVEADTCLYRSKKDGRNRTSTMRYG 311
             + +AD  LY++K +GRN+       
Sbjct: 331 TFLDQADQALYQAKNNGRNQIMFAAAQ 357


>UniRef50_A6Q2P1 Putative uncharacterized protein n=1 Tax=Nitratiruptor sp. SB155-2
           RepID=A6Q2P1_NITSB
          Length = 486

 Score =  248 bits (633), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 63/205 (30%), Positives = 100/205 (48%), Gaps = 13/205 (6%)

Query: 107 SIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK- 165
               +F   + + ++ I  +       AI+ +  +    A  D LT +++R    E  + 
Sbjct: 291 MFDTIFWQNILLGSILILFLFTILFYFAISRI--KFEEMATVDKLTGLFNRHKFQEIAEI 348

Query: 166 --SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGG 223
               S +  + L+V+L DID+FK IND YGH+ GD VL   A+ I++ +       R GG
Sbjct: 349 EIKRSHRHKRPLSVILFDIDHFKKINDTYGHDIGDVVLRELAKIIKQNIRKYDYAIRWGG 408

Query: 224 EEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDF 283
           EEF +  P  +      MAEK+RK VE   F    K   +T+S+GV S   +     +  
Sbjct: 409 EEFLILTPETDEKQAFAMAEKLRKAVESHTFPEVGK---VTISLGVASVDPN-----ESI 460

Query: 284 NKLMVEADTCLYRSKKDGRNRTSTM 308
           ++ + +AD  LY SK  GRN+T+  
Sbjct: 461 DQAIKKADNALYGSKLGGRNKTTVA 485


>UniRef50_Q30SB7 Diguanylate cyclase (GGDEF domain) n=1 Tax=Sulfurimonas
           denitrificans DSM 1251 RepID=Q30SB7_SULDN
          Length = 487

 Score =  248 bits (633), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 74/338 (21%), Positives = 138/338 (40%), Gaps = 42/338 (12%)

Query: 5   WFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLP 64
           WF       +L+ P M+ L       +     +      ++S+  ++V+     + F LP
Sbjct: 158 WFFGDSIGILLLTPIMVLLKENYKSLKNYDFNIQNISIALLSIYLAIVLFSFTDINFMLP 217

Query: 65  A--------LIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSP---FSIPQMFS 113
                    L+W   +       ++  +  ++ I   ++ +   S+          Q F 
Sbjct: 218 TTPLLFVLLLLWIVYKQGVLPGMIMALLITSIAIYYTSSGLGPFSIFGLKGTTIYLQEFI 277

Query: 114 ARLGIATMAICPI--------------------MVSFSVAAINSLMKQVALRADFDFLTQ 153
           A L I T+    +                    MV     ++    +++   A  D LT 
Sbjct: 278 AILVITTLFFGVLHQEINESKAKLEELNKNLENMVKEKTKSLMEANQKLNNLASKDSLTN 337

Query: 154 VYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQK 210
           +++R  + E +      S +    L ++++DID+FK +ND YGH+ GD+V+      I K
Sbjct: 338 IFNRRIIDEFISKETIKSKRYNNSLALIMIDIDHFKEVNDKYGHQVGDEVILSLVDIISK 397

Query: 211 IVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVG 270
            + +  +  R GGEEF + +P  N     ++A+ IRK V+   F    +    T+S+GV 
Sbjct: 398 NIRESDIFGRWGGEEFIILLPETNLNQATIVAQNIRKKVQEYRFDKVGQK---TISLGVS 454

Query: 271 SGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
              ++     DD    +   D  LY++K  GRNR  ++
Sbjct: 455 EFNSN-----DDSTVFIKRVDDALYKAKATGRNRVVSL 487


>UniRef50_Q2RNW0 Putative diguanylate cyclase (GGDEF domain) n=1 Tax=Rhodospirillum
           rubrum ATCC 11170 RepID=Q2RNW0_RHORT
          Length = 360

 Score =  248 bits (633), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 90/287 (31%), Positives = 135/287 (47%), Gaps = 24/287 (8%)

Query: 33  KAEQMMPAIALIVSVIASVVIGGAG-------SLAFPLPALIWCAVRYTPQVTCLL-TFV 84
           +    +    +  +VI +VV+GG         ++ FP+        R    V+ +  T  
Sbjct: 86  RLVAALIGHIIGGAVILTVVLGGKAQDAVFSWAVLFPVLPFFVLGQRLGLLVSIVFATTA 145

Query: 85  TGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVAL 144
           T  V I+ V +     S  +PF++            +A C ++  F         +Q+  
Sbjct: 146 TVGVTILAVLDGAQGFSWIAPFNLA---------GALAGCTVLAYFYEGTRAKAARQLET 196

Query: 145 RADFDFLTQVYSRSGLYEALKSPSL---KQTQHLTVMLLDIDYFKSINDNYGHECGDKVL 201
            A  D LT + +R GL +A     L   +    L++++LD+D+FKSIND YGHE GD VL
Sbjct: 197 LAKSDPLTGLANRRGLLDAFGGAVLTRSRAPHRLSLLVLDLDHFKSINDRYGHEAGDGVL 256

Query: 202 SVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTL 261
              A  I+ ++    L+AR+GGEEFA+ +P  +      +AEKIRK +E         +L
Sbjct: 257 CHVAHVIKGMIRANDLIARIGGEEFALLLPDTDLAGAREVAEKIRKAIESTALIGPGGSL 316

Query: 262 YLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
            +TVSIGV      Y     DF  L   AD  LY++KK GRNR S  
Sbjct: 317 SVTVSIGVAELDPQYP----DFAALFSSADHRLYQAKKAGRNRVSAA 359


>UniRef50_Q67JR0 Putative uncharacterized protein n=1 Tax=Symbiobacterium
           thermophilum RepID=Q67JR0_SYMTH
          Length = 425

 Score =  248 bits (633), Expect = 3e-64,   Method: Composition-based stats.
 Identities = 53/190 (27%), Positives = 86/190 (45%), Gaps = 7/190 (3%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLL 180
             + V   ++A   L   +   A  D LT  Y+R    E       +  +     +++L+
Sbjct: 219 VLVCVFRDISARKRLESDLKHLATTDGLTGAYNRRSFVEVCGQELQRADRRARPTSLLLM 278

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DID+FK +ND +GH  GD+VL       ++++  + +V R+GG+EFAV +P+        
Sbjct: 279 DIDHFKRLNDRFGHAAGDEVLRQIVETGRRVLRSEDVVGRIGGDEFAVLLPATTLEQAGR 338

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           +AE++R   E      +  T   TVS GV   +           +L+  AD  LY +K  
Sbjct: 339 VAEQLRTTYERLAVPARGGTATFTVSFGVAEWKPHLR----TVEELLQRADRALYAAKNA 394

Query: 301 GRNRTSTMRY 310
           GRN   T   
Sbjct: 395 GRNCVRTEEA 404


>UniRef50_Q2BQL8 Probable two-component response regulator n=1 Tax=Neptuniibacter
           caesariensis RepID=Q2BQL8_9GAMM
          Length = 505

 Score =  248 bits (633), Expect = 3e-64,   Method: Composition-based stats.
 Identities = 69/295 (23%), Positives = 125/295 (42%), Gaps = 17/295 (5%)

Query: 32  FKAEQMMPAIALIVSVIASVVIGGAGSLAFPLP-----ALIWCAVRYTPQVTCLLTFVTG 86
              E++ P IA + +    ++    G L   L       L+ C  +   ++  L   +T 
Sbjct: 214 HGIEKIWPMIATLRNEFNILLPSSKGELTTLLAEDQPDLLLLCTEQQWQEMLSLCQEITA 273

Query: 87  AVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSV---AAINSLMKQVA 143
             +   +  + +   +     +    +      T+   P ++   +     +     Q+A
Sbjct: 274 NKDDYTLPVAFVSADLDDQRELDAYNAGAADFLTLNRAPAVLQSRIQILMQLKQSQDQLA 333

Query: 144 LRADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKV 200
             A  D LTQV +R       E     + +  + L +++LDID+FK  ND YGH  GD  
Sbjct: 334 RSARVDGLTQVNNRREFERNIEMEWRRAQRSKRSLALIMLDIDHFKPFNDGYGHLAGDGC 393

Query: 201 LSVFARHIQKIV-GDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ-- 257
           L   A+ I+  +   + +V R GGEEF V +P  +     ++AE+IRK +       +  
Sbjct: 394 LRTVAQTIKHSIQRAQDMVCRYGGEEFVVILPETDLDGAQMIAERIRKAIAKLKINHEFS 453

Query: 258 QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGE 312
                +T+S GV     S        ++L++ AD  LY++K  GRN+ + ++  E
Sbjct: 454 STDNTITISAGVACLSPSQ---EGSPHELILLADQGLYQAKAQGRNQVAIVQTSE 505


>UniRef50_B1KMS8 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Shewanella woodyi
           ATCC 51908 RepID=B1KMS8_SHEWM
          Length = 482

 Score =  247 bits (632), Expect = 3e-64,   Method: Composition-based stats.
 Identities = 65/245 (26%), Positives = 110/245 (44%), Gaps = 8/245 (3%)

Query: 65  ALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAIC 124
            L + A +Y  +    +       + +L +   + +++ S  +I    +    I      
Sbjct: 230 PLTFIAKKYRLEYLSEIQKHISYDDTILDSRMDLTMTLPSNETIKVEMAFSTLIFEKKKL 289

Query: 125 PIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPS---LKQTQHLTVMLLD 181
            I     +     L  Q+ + A  D LT  Y+R    E  +       +Q Q  T++L+D
Sbjct: 290 VITAITDITERKRLETQLRILASTDPLTGAYNRRCFNELSQKSMSSTERQEQEFTILLID 349

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           +D+FKSIND +GH  GD VL    + I   + +  ++ R GGEEF VA+P+ +      +
Sbjct: 350 LDFFKSINDKFGHAAGDDVLIETVKAINTCIRESDILGRYGGEEFVVALPNSDNKKAREV 409

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
           A +IR  +E      Q   + LT SIG+ +    +        K + +ADT LY +K +G
Sbjct: 410 ANRIRLCIENMVVKTQGHDIKLTASIGLATSSGGHQ-----LEKQINQADTYLYYAKDNG 464

Query: 302 RNRTS 306
           RN+  
Sbjct: 465 RNQVV 469


>UniRef50_B3E5R5 Response regulator receiver modulated diguanylate cyclase n=2
           Tax=Geobacter RepID=B3E5R5_GEOLS
          Length = 316

 Score =  247 bits (632), Expect = 3e-64,   Method: Composition-based stats.
 Identities = 61/238 (25%), Positives = 116/238 (48%), Gaps = 11/238 (4%)

Query: 76  QVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAI 135
               LLT   G  +++    +  D  +  P +  ++   RL  A   +         +++
Sbjct: 80  TYLILLTSQEGKEKLIEGLEAGADEYLIKPVNEAELM-VRLKTARRILDLE------SSL 132

Query: 136 NSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHL---TVMLLDIDYFKSINDNY 192
              ++++   +  D LT  ++R  L + L     +  ++L   +++++D+D+FK IND +
Sbjct: 133 QKSLEEIKQLSIRDALTGAFNRGYLDQHLPHEIRRADRYLRDLSLIMMDLDHFKKINDTW 192

Query: 193 GHECGDKVLSVFARHIQKIVG-DKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVEL 251
           GH+ GD VL    R I   +  +   VAR GGEEF + +P  +     ++AE++R  +E 
Sbjct: 193 GHQAGDAVLQHCIRIIAGTIRHEVDWVARYGGEEFVLVLPETDRTGCRVVAERLRSLIEA 252

Query: 252 QPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
            P +++  TL +T S G  +   +     +  ++L+  AD CLY +K+ GRNR    +
Sbjct: 253 APCSFRSATLGITASFGTVTRTPADSRAINSPDQLLNLADQCLYAAKQAGRNRVVAAQ 310


>UniRef50_C5T8F5 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Acidovorax
            delafieldii 2AN RepID=C5T8F5_ACIDE
          Length = 1152

 Score =  247 bits (632), Expect = 3e-64,   Method: Composition-based stats.
 Identities = 55/196 (28%), Positives = 93/196 (47%), Gaps = 12/196 (6%)

Query: 124  CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQ---TQHLTVMLL 180
              + ++  V       + +   A  D LT + +R      L+   ++     +   +++L
Sbjct: 959  GRLWIAKDVTERRRHEQTLERLATTDALTGLANRRAFMARLEEERMRPSMGGRGGMLIML 1018

Query: 181  DIDYFKSINDNYGHECGDKVLSVFARHIQ-KIVGDKGLVARMGGEEFAVAVPSVNPVDGL 239
            D+D+FK +ND +GH  GD+VL   AR ++  ++    L  R+GGEEFAV +P     + L
Sbjct: 1019 DLDHFKRVNDTWGHAAGDEVLVHLARLLRGDLLRATDLAGRLGGEEFAVLLPDTTAEEAL 1078

Query: 240  LMAEKIRKGVELQPFTWQQK-TLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSK 298
             +AE++R+ +E          TL +T+S+GV       L        ++  AD  LY +K
Sbjct: 1079 GVAERLRRALEQSKIHVGDGATLQVTMSLGVAPITGDAL-------AVLAHADIALYEAK 1131

Query: 299  KDGRNRTSTMRYGEEV 314
              GRN+    R  E V
Sbjct: 1132 NTGRNKVVLARSDEPV 1147


>UniRef50_A1SRL2 Diguanylate cyclase n=1 Tax=Psychromonas ingrahamii 37
           RepID=A1SRL2_PSYIN
          Length = 611

 Score =  247 bits (632), Expect = 3e-64,   Method: Composition-based stats.
 Identities = 73/356 (20%), Positives = 139/356 (39%), Gaps = 56/356 (15%)

Query: 3   ADWFSEQFSTGVLIVPCMLTLAIPGVL-----------PRFKAEQMMPAIALIVSVI--- 48
           ++WFS+      + +  ++                      +   ++  +++  S+I   
Sbjct: 257 SNWFSDFSPVFFIALVMIMATQFTRSFLNTATESVNIDRLLQLIFVVAGLSIFFSLIGYR 316

Query: 49  -ASVVIGGAGSLAFPLPALI-----WCAVRYTPQVTC-LLTFVTGAVEIVLVANSVIDIS 101
             +V++G    L      +I          Y          +  G +  VL    +I ++
Sbjct: 317 DYAVILGLLSMLTSIFFPVIGWVIYLKGRSYARFYILGWSIWSLGMILAVLQHIGMIPVT 376

Query: 102 VGSPFSIPQMFSARLGIATMAIC----------------------------PIMVSFSVA 133
           + S  S    FS    + + A+                               +V+    
Sbjct: 377 LYSDLSTGLCFSIEAALLSFALADRFNQLRNEKEEIELIHIEHLKNDQQLLEQLVTERTE 436

Query: 134 AINSLMKQVALRADFDFLTQVYSRSGLYE---ALKSPSLKQTQHLTVMLLDIDYFKSIND 190
            +     +  L A  D LT + +R   +E        SL+    L +M++D+D+FKSIND
Sbjct: 437 ELEQAKDRAELLARTDPLTNMLNRRAFFECGSVEIKRSLRYKSSLAIMMIDLDHFKSIND 496

Query: 191 NYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVE 250
           NYGH  GD  L   A  ++ ++ +  ++ R+GGEEFAV +P  +      +A+++R G+E
Sbjct: 497 NYGHAAGDNALLSVANTLKAMIRNVDIIGRIGGEEFAVIIPHADLEIATELAQRLRLGIE 556

Query: 251 LQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
                   + + +T   GV S        ++  ++ +  AD  LY +K++GRNR  
Sbjct: 557 KVEIIIDNQPVKITACFGVTSID----IKSESLDEALKRADKALYLAKENGRNRVE 608


>UniRef50_Q0A8G7 Diguanylate cyclase n=1 Tax=Alkalilimnicola ehrlichii MLHE-1
           RepID=Q0A8G7_ALHEH
          Length = 237

 Score =  247 bits (632), Expect = 4e-64,   Method: Composition-based stats.
 Identities = 49/187 (26%), Positives = 82/187 (43%), Gaps = 11/187 (5%)

Query: 130 FSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQ---TQHLTVMLLDIDYFK 186
             +       +++   A  D LT + +R      L     +     + + V++ D+D+FK
Sbjct: 56  RDITERKRDQERIRYLATTDALTGIMNRGEFTRHLTKEIERAARFNRPVAVVMYDLDHFK 115

Query: 187 SINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIR 246
            +ND YGH+ GD+VL      +   +    + AR GGEEF + +P  +    +  AE++R
Sbjct: 116 RVNDTYGHDAGDEVLKTAVAQVNNAIRRVDVHARWGGEEFILLLPETDLAAAVKSAERLR 175

Query: 247 KGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
             +   PF    +   +T S GV +         D F+ L+  AD  LY +K  GRNR  
Sbjct: 176 AAIAEHPFK---QPERVTASFGVTTLGPR-----DRFDVLIKRADDALYLAKHAGRNRVE 227

Query: 307 TMRYGEE 313
            +     
Sbjct: 228 ALSPEAP 234


>UniRef50_Q2W1M0 Response regulator containing a CheY-like receiver domain and a
           GGDEF domain n=3 Tax=Magnetospirillum RepID=Q2W1M0_MAGSA
          Length = 477

 Score =  247 bits (631), Expect = 4e-64,   Method: Composition-based stats.
 Identities = 55/188 (29%), Positives = 93/188 (49%), Gaps = 9/188 (4%)

Query: 123 ICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVML 179
           +  I +   +     +  Q+   A  D LT   +R   + A +    + +++   ++V++
Sbjct: 292 MGTIGIVTDITERKHMESQLRHLATTDELTGCLNRRAFFVAAEQELERASRYGNAVSVLM 351

Query: 180 LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGL 239
           +DID+FK +ND +GH  GDK L      I+  + +     R+GGEEFA  +P       L
Sbjct: 352 IDIDHFKQVNDRHGHAVGDKALKAATAAIRANLREIDSFGRLGGEEFAAMLPETTLAGAL 411

Query: 240 LMAEKIRKGVELQPFTWQQK--TLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRS 297
           L+AE++R+ VE            L LT S+GV   +   +      ++++  ADT LYR+
Sbjct: 412 LVAERLRQAVEAIALPLGDDQPPLRLTTSLGVAERQPGEVA----VDQVLARADTALYRA 467

Query: 298 KKDGRNRT 305
           K +GRNR 
Sbjct: 468 KAEGRNRV 475


>UniRef50_B9ZM04 Diguanylate cyclase n=1 Tax=Thioalkalivibrio sp. K90mix
           RepID=B9ZM04_9GAMM
          Length = 291

 Score =  247 bits (631), Expect = 5e-64,   Method: Composition-based stats.
 Identities = 76/280 (27%), Positives = 124/280 (44%), Gaps = 16/280 (5%)

Query: 43  LIVSVIASVVIGGAGSL-AFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDIS 101
           L      ++V+G AG + A    A +   +  +   T  L          L     I ++
Sbjct: 2   LNWVANGAIVLGAAGLIYAQWNLARLLRELPESRVRTGWLLMFVLIPIFTLGYLGFIPLN 61

Query: 102 VGSPFSIPQMFSARLGIA--TMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSG 159
            G   SIP +    + +   +     +++++S       + ++   +  D LT +++R  
Sbjct: 62  WGLYHSIPDLLVPIIFLLGGSFVCSVVLLTYSSVESIRRITRLEHESITDPLTGLFNRRH 121

Query: 160 LYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKG 216
           +   L      S +  Q L+V++LDID FK IND  GH  GD +L   A+ +++ +    
Sbjct: 122 MDRRLDEEVARSRRYGQPLSVVMLDIDEFKGINDRLGHLAGDYILESIAQRLRQNLRRVD 181

Query: 217 LVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQK---------TLYLTVSI 267
           L AR GGEEF V  P  +    L +AEK+R  +   P   +            LY+TVS+
Sbjct: 182 LAARFGGEEFVVIAPHTDQDAALQLAEKLRSEIAQTPIILKGHEHVPPCAPDELYVTVSV 241

Query: 268 GVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
           GV S         D+ + L+  AD  LYR+K  GRNR  +
Sbjct: 242 GVASLNIE-PDSRDNADFLLQRADDALYRAKAGGRNRCES 280


>UniRef50_A4BIU7 Response regulator containing a CheY-like receiver domain and a
           GGDEF domain n=1 Tax=Reinekea blandensis MED297
           RepID=A4BIU7_9GAMM
          Length = 318

 Score =  247 bits (631), Expect = 5e-64,   Method: Composition-based stats.
 Identities = 60/191 (31%), Positives = 104/191 (54%), Gaps = 7/191 (3%)

Query: 117 GIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH-- 174
            +A +      ++ S   + +   ++A  +  D LTQ+Y+R+   E L +   +Q +H  
Sbjct: 127 NLAVIVYDVTDIATSKLELKAANDRLAQLSRTDGLTQLYNRAYWEEMLSNEFKRQKRHAH 186

Query: 175 -LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSV 233
            L++++ DID+FK +ND YGH+ GD V+   A  ++    +  +  R GGEEFA+ +   
Sbjct: 187 DLSLIMFDIDHFKKVNDTYGHQVGDDVIRAVAEEVRHNSRNTDIAGRYGGEEFALLLIDS 246

Query: 234 NPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTC 293
           +  + LL AE++RK +E +  +  +  L +TVS+GV   + S+      +N  +  AD  
Sbjct: 247 DAENALLFAERLRKAIENRRVSTPEGELQVTVSLGVAPWKESFHH----YNAWIEAADKA 302

Query: 294 LYRSKKDGRNR 304
           LY SK +GRNR
Sbjct: 303 LYTSKDEGRNR 313


>UniRef50_Q315M6 Diguanylate cyclase n=1 Tax=Desulfovibrio desulfuricans subsp.
           desulfuricans str. G20 RepID=Q315M6_DESDG
          Length = 403

 Score =  246 bits (630), Expect = 5e-64,   Method: Composition-based stats.
 Identities = 73/303 (24%), Positives = 132/303 (43%), Gaps = 12/303 (3%)

Query: 17  VPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVI---GGAGSLAFPLPALIWCAVRY 73
             C+L   +        A     A+ + + V+    +          F LP   +     
Sbjct: 98  AYCVLYFFLRTSGMLKVASDFALALTVTLGVLLIWRLNDQIAYILWLFALPPAAFFTFGT 157

Query: 74  TPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATM-AICPIMVSFSV 132
                 L   +   +    V+ + +     S     ++ +A   ++   A+     + + 
Sbjct: 158 KRAAVALGLLLIALLLSPFVSPAAMPPETFSLSYFVRVIAAFFTLSLFSALGEYSRAHTQ 217

Query: 133 AAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSIN 189
             + +L +++   A  D LT + +R G+Y+ L     + T+     +V+L D+D+FK++N
Sbjct: 218 RTLVALTREMEQCACTDPLTGLLNRRGIYDRLNEERARATRSGSTFSVILCDVDHFKNVN 277

Query: 190 DNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGV 249
           D +GH+CGD VL   A H ++ V  + +V R GGEEF   +P  +    L +AEK+R  V
Sbjct: 278 DCFGHQCGDHVLHQLAEHFRRSVRGQDVVCRWGGEEFLFILPETDEQGALNLAEKLRSTV 337

Query: 250 ELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
           E  P  +    + +T+S+GV        TLT+     +  AD  LY +K+ GRN+  +  
Sbjct: 338 EQTPVNYHGMPIDITLSLGV-----QECTLTESTEFHIRVADQKLYIAKEHGRNKVVSGN 392

Query: 310 YGE 312
             E
Sbjct: 393 IEE 395


>UniRef50_C0QBK1 GGDEF domain family protein n=1 Tax=Desulfobacterium autotrophicum
           HRM2 RepID=C0QBK1_DESAH
          Length = 430

 Score =  246 bits (630), Expect = 6e-64,   Method: Composition-based stats.
 Identities = 57/180 (31%), Positives = 97/180 (53%), Gaps = 11/180 (6%)

Query: 132 VAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSI 188
           + ++  + + +  +A  D LT +++R    + L S   +  ++   L+++L DID+FK +
Sbjct: 258 LQSLEGINELLEKQASTDALTGIFNRMKFNQTLTSEIKRAKRYRVALSLILFDIDHFKQV 317

Query: 189 NDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKG 248
           ND+YGH  GD VL   AR +   + +  + AR GGEEF +  P  +    + +AEK+R  
Sbjct: 318 NDSYGHLSGDTVLKHLARLVASNLREIDIFARWGGEEFVIQAPETSLESAIKLAEKLRSK 377

Query: 249 VELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
           +E   F   +K   +TVS GV + R+S   +      L+  AD  LYR+K+ GRN+  + 
Sbjct: 378 IENYVFPAPKK---ITVSFGVATFRSSDNDI-----TLVNRADEALYRAKEGGRNQVVSH 429


>UniRef50_A0L7F5 Cyclic nucleotide-binding protein n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0L7F5_MAGSM
          Length = 320

 Score =  246 bits (630), Expect = 6e-64,   Method: Composition-based stats.
 Identities = 54/184 (29%), Positives = 93/184 (50%), Gaps = 9/184 (4%)

Query: 129 SFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLK---QTQHLTVMLLDIDYF 185
           +  +   +   +++   A  D LT +Y+R    E+++    +       L++++LD+D+F
Sbjct: 139 NRVIIEGSERQRKLETFAKVDPLTGIYNRRWFDESMQRQMRRVEHSQNPLSLIMLDVDHF 198

Query: 186 KSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKI 245
           K  ND +GH+ GD+ L   A  I   +    + AR GGEEFAV +P  + V G ++AE++
Sbjct: 199 KRYNDTHGHQGGDEALIALAHTISLHLRPGDIAARYGGEEFAVVLPDTDAVSGRMIAERL 258

Query: 246 RKGVELQPFTWQQKT--LYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           R  VE       +      +T+S+GV     +     D  ++L+  AD  LY++K  GRN
Sbjct: 259 RTAVEALEIKDDEGNSLSGITISLGVAQTSGTV----DSVSELIATADAALYQAKNQGRN 314

Query: 304 RTST 307
           R   
Sbjct: 315 RVVV 318


>UniRef50_UPI0000384142 COG2199: FOG: GGDEF domain n=1 Tax=Magnetospirillum magnetotacticum
           MS-1 RepID=UPI0000384142
          Length = 445

 Score =  246 bits (629), Expect = 6e-64,   Method: Composition-based stats.
 Identities = 50/186 (26%), Positives = 83/186 (44%), Gaps = 7/186 (3%)

Query: 125 PIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLD 181
            + +   V     L +++   A  D LT + +R    E   +  ++  +    L V++LD
Sbjct: 262 FVALKEDVTETKRLQEELTRLASQDSLTGIANRRHFLERAHTEIIRAGRAKTPLAVLMLD 321

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           +D+FK IND YGH  GD  L   A   +  + +  L  R+GGEEF +  P  +       
Sbjct: 322 VDHFKKINDEYGHAAGDAALKALADTCRSTLRETDLFGRLGGEEFGILFPGDDLNAATEA 381

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
           AE++R  +     T    T+ +T S+G+   +          +  +  AD  LY +K+ G
Sbjct: 382 AERLRLAIAATKITIGGATIAITASLGLSLLQDGE----KSIDAALSRADQALYVAKQAG 437

Query: 302 RNRTST 307
           RNR   
Sbjct: 438 RNRLEI 443


>UniRef50_UPI0001C3940A response regulator receiver modulated diguanylate cyclase n=1
           Tax=Arthrospira platensis str. Paraca
           RepID=UPI0001C3940A
          Length = 392

 Score =  246 bits (629), Expect = 7e-64,   Method: Composition-based stats.
 Identities = 60/190 (31%), Positives = 90/190 (47%), Gaps = 9/190 (4%)

Query: 127 MVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDID 183
            +  S  A+    +++   A +D LTQV +R    E L        ++ + + ++L D+D
Sbjct: 180 ALERSRIALKKTNQELQRLALYDDLTQVANRRRFNEYLAYNWHRCSREQEPIALILCDVD 239

Query: 184 YFKSINDNYGHECGDKVLSVFARHIQKIV-GDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           YFK  ND +GH+ GD  L   AR I   +     LVAR GGEEFA+ +P+      + +A
Sbjct: 240 YFKPYNDTFGHQAGDDCLHKIARAISGAIQRSVDLVARYGGEEFAIILPNTPINGAVKVA 299

Query: 243 EKIRKGVELQPFTWQQKTLY--LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           E+IRK VE              +TVS+GV              + L+ +AD  LY++K  
Sbjct: 300 ERIRKQVENLRVPHPGSQSSDYVTVSLGVAC---KIPHSELSVDSLIAQADEALYQAKNQ 356

Query: 301 GRNRTSTMRY 310
           GRN T     
Sbjct: 357 GRNCTVIAES 366


>UniRef50_B9ZRW3 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Thioalkalivibrio
           sp. K90mix RepID=B9ZRW3_9GAMM
          Length = 791

 Score =  246 bits (629), Expect = 7e-64,   Method: Composition-based stats.
 Identities = 53/185 (28%), Positives = 87/185 (47%), Gaps = 11/185 (5%)

Query: 125 PIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLD 181
            I +   +     L   +  +A +D LT   +R      L   + +  +     +++LLD
Sbjct: 611 YIAMFHDITRQKELEAALEHQAFYDPLTDAANRGYFETLLDQEARRAQRYAHPCSLLLLD 670

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           ID+FK IND +GHE GD+VL      ++  + +  ++ R GGEEF V +P  +   G  +
Sbjct: 671 IDHFKRINDTFGHEVGDEVLRFLVHALKGRLREADVLGRWGGEEFVVLLPGTDAERGQHV 730

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
           AE++R+ V    F        +T+S+GV   R       +     +  AD  +Y +KK G
Sbjct: 731 AEQLREQVTATAFPCVGL---VTISLGVAECRP-----GESIRDWVKRADEAMYVAKKGG 782

Query: 302 RNRTS 306
           RNR  
Sbjct: 783 RNRVV 787


>UniRef50_A3Y5H4 Diguanylate cyclase (GGDEF domain) n=1 Tax=Marinomonas sp. MED121
           RepID=A3Y5H4_9GAMM
          Length = 419

 Score =  246 bits (629), Expect = 7e-64,   Method: Composition-based stats.
 Identities = 59/203 (29%), Positives = 97/203 (47%), Gaps = 6/203 (2%)

Query: 111 MFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLK 170
           +  + + I T  +  I              ++   A  D LT +Y+R      L     +
Sbjct: 197 LLLSSIAIITAFVIGIGYKKVQQIREEYELELIEMATKDKLTNIYNRRSFEARLLQDLKQ 256

Query: 171 Q---TQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFA 227
                  L+++L D+D+FK +ND YGH+ GD VL++ A   Q+ V    +VAR GGEEF 
Sbjct: 257 YDKFQTELSIILFDVDHFKFVNDTYGHQAGDSVLTLLAEIAQQTVRSNDIVARYGGEEFI 316

Query: 228 VAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLM 287
           + +P+       ++AEK+R  +E   F  Q   + +T+S+GV            + + L+
Sbjct: 317 ILLPNTGKNGSQVIAEKLRSAIENAAFDTQSYKIQITISLGVACISDVQHP---NLDNLI 373

Query: 288 VEADTCLYRSKKDGRNRTSTMRY 310
             AD  LY +K +GRN+ S M+ 
Sbjct: 374 KSADDALYYAKHNGRNQVSYMQT 396


>UniRef50_Q087A8 Diguanylate cyclase n=1 Tax=Shewanella frigidimarina NCIMB 400
           RepID=Q087A8_SHEFN
          Length = 321

 Score =  246 bits (629), Expect = 8e-64,   Method: Composition-based stats.
 Identities = 60/219 (27%), Positives = 107/219 (48%), Gaps = 10/219 (4%)

Query: 93  VANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLT 152
           +++ +I  +  S     ++           I  I +S  + A   L  ++   A+ D LT
Sbjct: 110 LSDDIIVDTPASLIVYHEVKQPLYNHKGTLIGLIGISTDITAAYHLRSKLERLANTDPLT 169

Query: 153 QVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQ 209
            +++R       +     + +  Q  ++M++DID FK +ND YGH  GD+V+   A    
Sbjct: 170 GLFNRRSFTSFCEHEFFRATRYFQPFSLMIIDIDLFKKVNDTYGHLVGDEVIKRVANICN 229

Query: 210 KIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGV 269
           + V +  ++AR+GGEEFA+ +P  +     ++AE++R+  +      +QKT  +T+SIGV
Sbjct: 230 EHVREADVLARIGGEEFAILLPDTDIDSAYVLAERLREAQQQYE---EQKTPSITISIGV 286

Query: 270 GSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
            + R+        F ++   AD  LY SK  GRN  +  
Sbjct: 287 ATLRSQ----DKAFLEIFKRADKALYSSKNVGRNSVNVA 321


>UniRef50_A3WMD3 Phytochrome sensor diguanylate cyclase/phosphodiesterase n=1
           Tax=Idiomarina baltica OS145 RepID=A3WMD3_9GAMM
          Length = 689

 Score =  246 bits (628), Expect = 9e-64,   Method: Composition-based stats.
 Identities = 58/219 (26%), Positives = 95/219 (43%), Gaps = 14/219 (6%)

Query: 94  ANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQ 153
            +    I         +  +  L I         +      +    +++      D LTQ
Sbjct: 480 VDGYAPIWTEIQIEAAKTLAEDLAIGA---SAYQIEQLNQELTEANQRLEHLVHTDALTQ 536

Query: 154 VYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQK 210
           V++R  + + L+       +  + L V+LLDID+FK +ND+YGH+ GDKVL + +  I +
Sbjct: 537 VWNRYHMEQTLEEEVKRCKRHGRDLAVILLDIDHFKRVNDDYGHDVGDKVLKLISEAIHQ 596

Query: 211 IVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVG 270
            +    +  R GGEEF +  P  +      +AE++R+ +    F    K   +T S GV 
Sbjct: 597 WLRSSDVFGRWGGEEFLIIAPETDLESANQLAERLRRRLSNLQF---DKVGQVTASFGVA 653

Query: 271 SGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
               S     +D N L+  AD  LY+ K+ GRN      
Sbjct: 654 ELLPS-----EDRNSLVKRADNALYQVKESGRNSVEVSP 687


>UniRef50_Q2SNU2 Response regulator containing a CheY-like receiver domain and a
           GGDEF domain n=1 Tax=Hahella chejuensis KCTC 2396
           RepID=Q2SNU2_HAHCH
          Length = 367

 Score =  246 bits (628), Expect = 9e-64,   Method: Composition-based stats.
 Identities = 74/309 (23%), Positives = 128/309 (41%), Gaps = 26/309 (8%)

Query: 13  GVLIVPCMLTL-AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAV 71
             L + C L L  +         +        +V ++   +I G G     +   +W  V
Sbjct: 55  SALFLFCALMLMNVISYNRTLNQQLFKTLFLWLVGLLFLYLIAGGGESNTGI---LWFYV 111

Query: 72  RYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFS-----IPQMFSARLGIATMAICPI 126
            + P V  +    TG+  ++++   +  I                F  R       +   
Sbjct: 112 -FPPFVFYVAGLRTGSWMLIIMVALIAIIFRFPELPWVRTVYNLDFQLRFAATVSFVSVF 170

Query: 127 MVSFSVAAINSLMKQV-------ALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLT 176
                 +      +++          A  D LTQ+ +R  + + L+    +  +   H +
Sbjct: 171 AFVMDHSRRK-ARQELINMARLYEKAARTDELTQLPNRRDMQQQLEKEYFRYKRHGSHFS 229

Query: 177 VMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPV 236
           V+LLDID+FK IND YGH+ GD VL   +  +        + AR GGEEF + +P  + V
Sbjct: 230 VILLDIDHFKMINDTYGHDAGDFVLMKISELLVNACRKMDMAARWGGEEFLIQLPDTSLV 289

Query: 237 DGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYR 296
             L +AE++RK +E  P  ++ + +  T+S GV S     ++   D   L+ +AD  LY+
Sbjct: 290 QALTLAERLRKSIEASPLQYKNQEIRYTISCGVCS-----ISQAKDLASLLKQADVNLYQ 344

Query: 297 SKKDGRNRT 305
           +K  GRN  
Sbjct: 345 AKIKGRNMV 353


>UniRef50_C6BZS4 Diguanylate cyclase with PAS/PAC and GAF sensors n=1
           Tax=Desulfovibrio salexigens DSM 2638 RepID=C6BZS4_DESAD
          Length = 635

 Score =  246 bits (628), Expect = 9e-64,   Method: Composition-based stats.
 Identities = 53/185 (28%), Positives = 92/185 (49%), Gaps = 8/185 (4%)

Query: 127 MVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLK---QTQHLTVMLLDID 183
           + +  +     ++++V   A  D+LT  ++R       ++   +       L +M+LDID
Sbjct: 451 ITAHDITEQKEMLEEVKRLASTDYLTGAHNRRHFMSRAETELDRLTRYGGELYLMMLDID 510

Query: 184 YFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAE 243
           +FK+IND YGH  GD VL    +   + +    +  R+GGEEFA  +   +    + +AE
Sbjct: 511 HFKNINDTYGHSVGDVVLKEMVKCCIETLRTSDVFGRLGGEEFAALLVHGSIDSAIQVAE 570

Query: 244 KIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           ++R+ +E       +  + LTVSIG+    A      +D    +  AD CLY++K+ GRN
Sbjct: 571 RLREAIEDMEVRIGRHVVKLTVSIGLTMVCA-----DEDIEIALKHADKCLYQAKEQGRN 625

Query: 304 RTSTM 308
           R  + 
Sbjct: 626 RVVSY 630


>UniRef50_A0L4D8 Diguanylate cyclase n=2 Tax=cellular organisms RepID=A0L4D8_MAGSM
          Length = 464

 Score =  246 bits (628), Expect = 9e-64,   Method: Composition-based stats.
 Identities = 57/233 (24%), Positives = 104/233 (44%), Gaps = 4/233 (1%)

Query: 81  LTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMK 140
           L+ +     +  + +    +   +     Q  S    ++       +    +  +   +K
Sbjct: 223 LSRIRTTTRLGDLESLRGALVTEAEALRSQTQSLATSLSESQAQLDLTRKQLQQVQDDLK 282

Query: 141 QVALRADFDFLTQVYSRSGLYEALKSPS---LKQTQHLTVMLLDIDYFKSINDNYGHECG 197
           +    +  D LTQV +R  L+++L   +    +  + L+++++D+D+FK IND YGH  G
Sbjct: 283 KAKEESLTDPLTQVANRRALFQSLTRETARTRRYGEPLSLIIIDLDHFKKINDTYGHPVG 342

Query: 198 DKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ 257
           D+VL   A H + ++ D   +AR GGEEF   +P       +  AE+IR  V    F  +
Sbjct: 343 DRVLKEVAGHARALLRDSDTLARYGGEEFVALLPETTLPQAMEKAEQIRLSVAAMRFKLK 402

Query: 258 QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRY 310
            ++L ++ S+GV           ++    +  AD  LYR+K  GRN       
Sbjct: 403 GESLSISASLGVAQLDDGASQDANN-EAFVHRADQALYRAKSGGRNCVIQADP 454


>UniRef50_B3PIC1 Sensory box/GGDEF family protein n=5 Tax=Gammaproteobacteria
           RepID=B3PIC1_CELJU
          Length = 322

 Score =  246 bits (628), Expect = 9e-64,   Method: Composition-based stats.
 Identities = 56/194 (28%), Positives = 95/194 (48%), Gaps = 7/194 (3%)

Query: 117 GIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ--- 173
            I  +       + +  A     KQ+   +  D LT +++R      L     +  +   
Sbjct: 130 HICVIIYDVTDTAVNKIAQQHANKQLQNLSRTDHLTSLFNRGYWELRLIQEFKRYDRYES 189

Query: 174 HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSV 233
             ++++LDID+FK INDNYGH  GD+ +   +R I++ V D  +  R GGEEF + + S 
Sbjct: 190 PSSLIMLDIDHFKKINDNYGHTVGDEAIRCVSRVIKEQVRDLDIAGRYGGEEFGIILTST 249

Query: 234 NPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTC 293
           N     ++AE++R  +E Q    +   ++ T+S+GV            D  + + +AD  
Sbjct: 250 NGDGACVIAERLRSIIEKQTVYAEGHEIHFTISLGVAELNDHMH----DHRQWIEKADHA 305

Query: 294 LYRSKKDGRNRTST 307
           LY+SK+ GRNR + 
Sbjct: 306 LYKSKESGRNRCTL 319


>UniRef50_Q04S93 GGDEF domain receiver component of a two-component response
           regulator n=4 Tax=Leptospira RepID=Q04S93_LEPBJ
          Length = 330

 Score =  246 bits (628), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 67/280 (23%), Positives = 113/280 (40%), Gaps = 16/280 (5%)

Query: 46  SVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSP 105
             +  + I   G   F +  LI            ++T +  +  +    +S     V  P
Sbjct: 54  CSLILLDILLPGVTGFEILELIREKKELKDIPVIMITALKESNVLQKAFDSGAIDYVIKP 113

Query: 106 FSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVAL-------RADFDFLTQVYSRS 158
           F   ++ +       +             +  L  Q+          +  D LT +Y+R 
Sbjct: 114 FDATELLARVRSALRLFEEMTRRKEREKELEKLTDQLQEVNSYLVAISRTDSLTGLYNRR 173

Query: 159 GLYEALKSPSLK---QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIV-GD 214
             YE L +   +       + +++LDID+FK  ND YGH+ GD+ L   AR I+      
Sbjct: 174 YFYEILTTEWKRCWRTGAGIALIMLDIDHFKLYNDTYGHQGGDQCLKQVARAIRDCARRA 233

Query: 215 KGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY--LTVSIGVGSG 272
             + AR GGEEFAV +P  N  + ++++  I + VE              +TVSIG+ + 
Sbjct: 234 GDVAARYGGEEFAVILPETNESNAVVVSRNILENVEKMAIPHSASKTNSIVTVSIGMATL 293

Query: 273 RASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGE 312
             S     +   +L+  AD  LY +K++GRN       G+
Sbjct: 294 SPS---PENSITELIERADKALYLAKEEGRNCLRFYPQGD 330


>UniRef50_A4VQQ9 GGDEF domain protein n=1 Tax=Pseudomonas stutzeri A1501
           RepID=A4VQQ9_PSEU5
          Length = 466

 Score =  246 bits (628), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 68/238 (28%), Positives = 111/238 (46%), Gaps = 19/238 (7%)

Query: 71  VRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSF 130
           V      T  +        ++ V+  VI +++     +  + S+R               
Sbjct: 243 VVVLLWPTDFMAAFQERKTLLTVSAGVISLALSVVALLIFLLSSRYF------------Q 290

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKS 187
           S+A +     Q+A  A+ D LT V SR      L++   +  +H   L++++LDID+FK 
Sbjct: 291 SIARLRLAHGQLAQLANTDVLTGVSSRRAFLAGLEAELARARRHNESLSLLMLDIDHFKR 350

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           +ND +GH  GD VL  F+     ++    L+ R+GGEEFA+ +P  +      +AEKIR 
Sbjct: 351 VNDVHGHPIGDAVLKQFSETCAGMLRAHDLLGRLGGEEFAIVLPHTDAEGARCVAEKIRT 410

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
            V   P       + +TVSIG+         L  + ++LM  AD  LY +K+ GRN+ 
Sbjct: 411 AVAQTPMPTAAGDITVTVSIGLAQMEG----LPGEVDQLMARADQALYEAKRGGRNQV 464


>UniRef50_Q489Q4 Sensory box/GGDEF domain protein n=1 Tax=Colwellia psychrerythraea
           34H RepID=Q489Q4_COLP3
          Length = 451

 Score =  246 bits (628), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 61/187 (32%), Positives = 99/187 (52%), Gaps = 8/187 (4%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLL 180
             I  S  V  +  L ++  L A+ D LT +Y+R    E  +    +  ++   +T++ +
Sbjct: 267 ALIGFSTDVTELFKLKEEFKLLANTDPLTNLYNRRFFIEQAEKEYQRAKRYSLSMTLISI 326

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DID+FKSIND +GH  GD+VL   A+ ++  +    ++AR+GGEEF++ +P  + +  + 
Sbjct: 327 DIDHFKSINDQFGHPAGDQVLIEIAKQLKASLRQTDILARIGGEEFSILLPETSAMSAMT 386

Query: 241 MAEKIRKGVELQPFTWQ-QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKK 299
            AE+I++       T   Q  + L+VSIGV S  AS       F+ L   AD  LY++K 
Sbjct: 387 FAERIKEEQSRLIITGDWQGEINLSVSIGVSSLIAS----DKAFDVLFSRADKALYQAKN 442

Query: 300 DGRNRTS 306
            GRN   
Sbjct: 443 TGRNTVC 449


>UniRef50_B0TJ24 Periplasmic/7TM domain sensor diguanylate cyclase n=4
           Tax=Shewanella RepID=B0TJ24_SHEHH
          Length = 623

 Score =  246 bits (628), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 78/322 (24%), Positives = 141/322 (43%), Gaps = 28/322 (8%)

Query: 10  FSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIG--------------G 55
             + ++++   L  A  G             + L   +  ++ +G              G
Sbjct: 312 MLSCIMLMYMSLAQAFKGNKLAKLFAIGWAGMMLGALLSGAIYLGLLHWDLQAKTPFILG 371

Query: 56  AGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSAR 115
                  + AL+  A+RY  +    L     A+     A    + ++       +  +  
Sbjct: 372 LSIEVIFMAALL--AIRYNDERLAKLQIQQDALLQAKKAEETKEEALHIEARSSEKLAKM 429

Query: 116 LGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQT 172
           +   T+ +       ++  +N   +++  +   D LT V +R+     + +    S +Q 
Sbjct: 430 VQERTLEL-----EIALRELNEANQKLTEQTRIDSLTGVKNRASFDRRILAEGRISRRQQ 484

Query: 173 QHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIV-GDKGLVARMGGEEFAVAVP 231
             L++++LDID FK IND+YGH  GD+ L V A  +++I+     LV+R GGEEFA+ +P
Sbjct: 485 APLSILMLDIDRFKLINDSYGHLAGDQALRVIADQLKQILKRPTDLVSRFGGEEFAIILP 544

Query: 232 SVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEAD 291
           + + +    +AE IRK +   P  W    + LTVSIGV S     +T  +    L+ +AD
Sbjct: 545 NTDKIGAQQVAETIRKVISKLPICWGGNRIRLTVSIGVSS---EIITSEEHTTLLLEQAD 601

Query: 292 TCLYRSKKDGRNRTSTMRYGEE 313
             LY++K DGRN+       ++
Sbjct: 602 KALYQAKNDGRNQVKLYSPDQD 623


>UniRef50_A9WIR5 Diguanylate cyclase n=3 Tax=Chloroflexus RepID=A9WIR5_CHLAA
          Length = 589

 Score =  245 bits (627), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 64/249 (25%), Positives = 112/249 (44%), Gaps = 9/249 (3%)

Query: 65  ALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAIC 124
           AL   AV+  P++   L   +     ++V + +I   +           A L    +   
Sbjct: 340 ALPEPAVQLLPEIEGELADGSLLAAPLIVGDRIIGALLVWSNHHDAYTMADLNALELLAA 399

Query: 125 PIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLD 181
            + V+   A       Q+  +A  D LT + +R    + L     +  +    +++ ++D
Sbjct: 400 TVAVALHNAFR---FAQIQSQAITDNLTGLANRRHFLQVLHQEMERNRRYHTPVSIAMID 456

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           +D+FK IND +GH  GD VL   AR  ++ + D  ++AR GGEEF + +P       L  
Sbjct: 457 VDHFKQINDTFGHIAGDYVLREIARRCRQQLRDVDVLARYGGEEFGLILPETTYEQALKA 516

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
            E++R  +   P     + +  T+SIGV S   +      D + L+ +AD  LY +K+ G
Sbjct: 517 TERLRTVLATTPIMIDGRQINPTISIGVASFHPTVYP---DPSSLIADADRALYLAKQQG 573

Query: 302 RNRTSTMRY 310
           RNR   ++ 
Sbjct: 574 RNRVCGVQE 582


>UniRef50_C3JRE9 Diguanylate cyclase n=2 Tax=Rhodococcus erythropolis
           RepID=C3JRE9_RHOER
          Length = 489

 Score =  245 bits (627), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 83/302 (27%), Positives = 141/302 (46%), Gaps = 10/302 (3%)

Query: 17  VPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQ 76
           +P  L      +  R  A   +P +A    V  ++ I G  +L  P+PAL+WCA R +  
Sbjct: 159 IPSSLAEFRRKLTARTVAALSVPLLATAACVPIALSIEGPIALVLPIPALLWCATRISVP 218

Query: 77  VTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAIN 136
            T  ++ V     +++  +  +DI   +  +  +     + +  +A+ PI V+ +     
Sbjct: 219 STAFVSVVWSVWSLMMAGSGRLDIGDQAASTWNEDVITSIAVTLIALGPIAVACATEERR 278

Query: 137 SLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYG 193
           +  +++ L  +FD LT V SR       ++    + +    + +++LD+D+FKSIND +G
Sbjct: 279 AAERELFLAVEFDHLTGVLSRGAFLGHAEAELADAARTQSPVGLLMLDLDHFKSINDTHG 338

Query: 194 HECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP 253
           H  GD VL+ FA      + D  L+ R+GGEEFAV +P  +    + +AE +R       
Sbjct: 339 HMTGDSVLANFAERAADRLSDGDLIGRLGGEEFAVLLPDCSFTRAIDVAEAVRGAQVEYS 398

Query: 254 FTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEE 313
                  +  TVS+GV     +        + LM  AD  LY +K+ GRN     R G +
Sbjct: 399 AESD---VTSTVSVGVAWVDHATPA----LSTLMSVADEALYDAKRAGRNLVKVHRVGND 451

Query: 314 VV 315
            V
Sbjct: 452 TV 453


>UniRef50_C0QLY1 Two domain sensory box histidine kinase (PAS/PAC domain/GGDEF
           domain protein) n=1 Tax=Desulfobacterium autotrophicum
           HRM2 RepID=C0QLY1_DESAH
          Length = 440

 Score =  245 bits (627), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 56/201 (27%), Positives = 95/201 (47%), Gaps = 8/201 (3%)

Query: 108 IPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP 167
               FS  L I+      I +   +    ++ K++   A  D LT   +R       +  
Sbjct: 240 FFISFSRSLDISGKFSNAIAIIEDITKRKTMEKELEKLATTDPLTGAKNRRSFLNLFEKE 299

Query: 168 SLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGE 224
             +  ++   L ++++DID+FK INDN+GHE GDK+L++       ++ D  + AR GGE
Sbjct: 300 MKRSKRYNYTLALVMIDIDHFKKINDNFGHETGDKILNLLVAKCHSVLRDSDIFARWGGE 359

Query: 225 EFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKT-LYLTVSIGVGSGRASYLTLTDDF 283
           EF + +P  + +     AE++R  +          T +  TVSIG        +      
Sbjct: 360 EFIILLPETDLLQASSAAERLRGALAQSELRTNDGTNINFTVSIGFTIFGNKNIL----I 415

Query: 284 NKLMVEADTCLYRSKKDGRNR 304
           ++++ +AD  LY +KK GRNR
Sbjct: 416 DEIIKKADKALYLAKKQGRNR 436


>UniRef50_Q8DCJ9 FOG: GGDEF domain n=3 Tax=Vibrio RepID=Q8DCJ9_VIBVU
          Length = 479

 Score =  245 bits (626), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 64/269 (23%), Positives = 116/269 (43%), Gaps = 5/269 (1%)

Query: 42  ALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDIS 101
            L+ +     + G +         + + ++R        +       +   +A + + + 
Sbjct: 207 ILMTNDFICQLFGMSEQDVLSHHPMDFISLRSRDLFQRYIQKTINEQDSQEIARADLLLM 266

Query: 102 VGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY 161
           +     IP   +    +       IM    ++    L   +   A  D LT  ++R    
Sbjct: 267 LPEKKDIPIEMAFSRLVFEGKPMIIMSITDISERKKLEAMLRNLAATDPLTGAFNRRSFM 326

Query: 162 EALK---SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLV 218
           E  +       +    L++M+LDID+FK  ND+YGH  GD VL    +       +  ++
Sbjct: 327 EQAEKSIRTCQRWNCPLSIMILDIDHFKQFNDSYGHAAGDLVLVELVKMADLSTREIDII 386

Query: 219 ARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLT 278
            R+GGEEFAV +P +   +   +A+++R  VE     ++Q+ L +T+SIGV + + S L 
Sbjct: 387 GRLGGEEFAVVLPGLGEKEAFEVAKRLRSVVENMQVNYEQQPLQMTISIGVATLQPSELN 446

Query: 279 LTDDFNKLMVEADTCLYRSKKDGRNRTST 307
                 +LM +AD  LY +K  GRN   +
Sbjct: 447 TP--LEQLMKQADEGLYYAKAHGRNCVIS 473


>UniRef50_Q1K485 Diguanylate cyclase n=1 Tax=Desulfuromonas acetoxidans DSM 684
           RepID=Q1K485_DESAC
          Length = 370

 Score =  245 bits (626), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 55/184 (29%), Positives = 99/184 (53%), Gaps = 5/184 (2%)

Query: 128 VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEAL---KSPSLKQTQHLTVMLLDIDY 184
           ++ ++  I     ++A  A  D LT  ++R    E        + +  Q L++++ DID+
Sbjct: 184 LNEALDTIKKRNAEIAELAVRDSLTGSFNRGYFNETFPGAIRRAQRYQQSLSLIMCDIDH 243

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIVGDK-GLVARMGGEEFAVAVPSVNPVDGLLMAE 243
           FK IND+YGH+ GD+V+   A+ + + +      +AR GGEEF + +P  N    L++AE
Sbjct: 244 FKLINDHYGHQTGDRVIKSVAQGLAQSLRQGVDWLARYGGEEFVIVLPETNLEGALVVAE 303

Query: 244 KIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           ++R+ +  Q      +++ LT S GV      + ++    N ++  AD CLY++KK+GRN
Sbjct: 304 RMRRSIADQEIACDPQSIRLTASFGVAGCDPEHASML-TGNGMIAAADRCLYQAKKEGRN 362

Query: 304 RTST 307
              +
Sbjct: 363 CCCS 366


>UniRef50_A4XVW9 Periplasmic/7TM domain sensor diguanylate cyclase n=1
           Tax=Pseudomonas mendocina ymp RepID=A4XVW9_PSEMY
          Length = 638

 Score =  245 bits (626), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 75/319 (23%), Positives = 129/319 (40%), Gaps = 22/319 (6%)

Query: 10  FSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASV----VIGGAGSLAFPLPA 65
           F + +L+  C +   +  +L            AL   V+ +     ++ G G L + L  
Sbjct: 318 FGSFILLGACAVAAFLITLLRWRAGFAAARLFALGWFVLIAASLASILSGTGLLPYSLLT 377

Query: 66  L----IWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATM 121
           L    I   +  T     L   +    E    A + + I+        Q     L     
Sbjct: 378 LHAQQIGGLIEMTVFSIALAARIRHIQEAKRQAQTQL-IAQERHLRAEQARHLELQTQIS 436

Query: 122 AICPIMVSFSVAAINS-------LMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ- 173
                 V    A +            ++A     D LT +++R  L E L     +  + 
Sbjct: 437 ESLEQRVQERTATLQETLHQLSNANLRLAELNRRDGLTGLFNRQTLSEELTRACARAERG 496

Query: 174 --HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVP 231
              + +++LD+D+FK +ND YGH  GD  L   A+ IQ+ +    L+AR GGEEF   + 
Sbjct: 497 KQSVAILMLDLDHFKQVNDRYGHLAGDACLRHAAQRIQQRLRSSDLLARFGGEEFVALLD 556

Query: 232 SVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEAD 291
           + +    L +AE++R  +   P  +QQ ++ L++SIG+ +G     +        +  AD
Sbjct: 557 NTSLDGALDLAEQLRDDLARHPCPYQQHSIPLSLSIGLHAGVPHDPSCG---EHWLDLAD 613

Query: 292 TCLYRSKKDGRNRTSTMRY 310
             LYR+K  GRN+  +   
Sbjct: 614 RALYRAKAGGRNQVVSYEA 632


>UniRef50_A4C957 Putative uncharacterized protein n=1 Tax=Pseudoalteromonas tunicata
           D2 RepID=A4C957_9GAMM
          Length = 639

 Score =  245 bits (626), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 61/195 (31%), Positives = 98/195 (50%), Gaps = 7/195 (3%)

Query: 116 LGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSG---LYEALKSPSLKQT 172
           L  +  A   I++S  V     + K++   A+ D LTQ+ +R       + +   +  + 
Sbjct: 446 LVNSLFAAILILLSVFVYRQVKVSKRLNRLANTDSLTQLANRRYTFHFAKIVFKEAQIEQ 505

Query: 173 QHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPS 232
           + L++++ DID+FK INDNYGH  GD+VL   A   Q  + +  L+ R+GGEEF V + +
Sbjct: 506 KPLSIIIFDIDHFKRINDNYGHPFGDEVLMAVADKAQAGLREPDLLGRIGGEEFMVVLKN 565

Query: 233 VNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADT 292
                 + +AE++R+ +    F   Q+ + +T S GV           DDF  L   AD 
Sbjct: 566 TPINQAVEIAERMRELIAQLSFAAAQQQVKVTASFGVAQFN----VDVDDFGSLFQHADE 621

Query: 293 CLYRSKKDGRNRTST 307
            LYR+K  GRN+   
Sbjct: 622 ALYRAKNAGRNQVVC 636


>UniRef50_A1ASG6 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Pelobacter
           propionicus DSM 2379 RepID=A1ASG6_PELPD
          Length = 505

 Score =  245 bits (626), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 62/179 (34%), Positives = 95/179 (53%), Gaps = 11/179 (6%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPS---LKQTQHLTVMLLDIDYFKS 187
            +     + +++   ++ D LT +Y+R  LY+ L        +    LT+MLLDID+FK 
Sbjct: 318 DITERTRMQEELREASERDPLTSLYNRRKLYQLLTVELTRTRRHGHPLTLMLLDIDHFKR 377

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           IND +GH+ GD VL+  A  I  I+    ++AR GGEEF +A P  +     ++AEKIR 
Sbjct: 378 INDTFGHDSGDLVLTQVAELISAILRSTDILARYGGEEFVIACPETDMDGAAVLAEKIRS 437

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
            + +  F        +T+S+G+    +      DD N L+  ADT LY +K+ GRNR  
Sbjct: 438 SIAMFSFPTVG---AVTISVGISLLESK-----DDINALIKRADTALYAAKEMGRNRVV 488


>UniRef50_C1TNC9 Diguanylate cyclase (GGDEF) domain-containing protein n=1
           Tax=Dethiosulfovibrio peptidovorans DSM 11002
           RepID=C1TNC9_9BACT
          Length = 494

 Score =  245 bits (626), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 67/267 (25%), Positives = 121/267 (45%), Gaps = 13/267 (4%)

Query: 44  IVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVG 103
           ++ +  S+++         +  L++   R     T ++  +    E     + ++D+   
Sbjct: 237 LLWLQYSLILAFLAVTGGTVFFLLFFLRRRFDPYTRMVGALVDYSERKTDLDGLLDVMSE 296

Query: 104 SPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEA 163
                    S         I  +++   +  I S   ++   A+ D LT +++R  + + 
Sbjct: 297 ISSGASDEISYICEALKDMI--LVLKDKMENIQSYSDRLEYLANRDSLTGLWNRRKMDQI 354

Query: 164 LKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVAR 220
           L S + + +++   L+V+++DID+FK++NDN+GHE GD VLS  A  ++        V R
Sbjct: 355 LLSETERSSRYGSSLSVVMVDIDHFKNVNDNFGHEVGDTVLSSIAALMKNCTRAGDSVGR 414

Query: 221 MGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLT 280
            GGEEF V +P  +    L  AE++R  VE   F      + +T S GV   R+      
Sbjct: 415 WGGEEFLVVLPETDVKGALEYAERMRSAVEDNVFHDD---IRITSSFGVTQYRSGEP--- 468

Query: 281 DDFNKLMVEADTCLYRSKKDGRNRTST 307
              N+ +  AD  LY +K+ GRNR   
Sbjct: 469 --VNEFVARADEALYDAKEKGRNRVEI 493


>UniRef50_B4U5K2 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Hydrogenobaculum
           sp. Y04AAS1 RepID=B4U5K2_HYDS0
          Length = 901

 Score =  245 bits (626), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 56/187 (29%), Positives = 91/187 (48%), Gaps = 11/187 (5%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLL 180
             + +   +   + ++K     +  D LT + +R  L + L+     + +  + L+V++ 
Sbjct: 722 LILCILQDITEESMIIKYFEELSIKDDLTGICNRRCLEDKLEEYLTLAKRYNRPLSVIMF 781

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DID+FK IND+YGH+ GDKVL   A  +   +    ++AR GGEEF +  P     D   
Sbjct: 782 DIDFFKHINDSYGHDIGDKVLKTIANIVLSNIRATDILARYGGEEFVIISPETTLEDAKA 841

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           +AEK+RK +E   F        +T S GV S         D    ++   D  LY++K++
Sbjct: 842 LAEKLRKEIENFLFEEG---FSITCSFGVTSLNQE-----DTKETILKRVDEALYKAKRE 893

Query: 301 GRNRTST 307
           GRNR   
Sbjct: 894 GRNRVVA 900


>UniRef50_Q6AJ00 Putative uncharacterized protein n=1 Tax=Desulfotalea psychrophila
           RepID=Q6AJ00_DESPS
          Length = 571

 Score =  245 bits (625), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 53/186 (28%), Positives = 93/186 (50%), Gaps = 8/186 (4%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSL---KQTQHLTVMLL 180
             + +           +++   A  D LT++ +R   +              Q L+V++L
Sbjct: 388 GVLWMMDDATKRKKAEEKLVRIAATDSLTKLNNRRHFFSLGHEELALHLHNAQPLSVLML 447

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DID+FK++ND  GH+ GDKVL +F++     +    ++ R+GGEEFAV + +        
Sbjct: 448 DIDHFKNVNDTLGHQAGDKVLKIFSKICAVNLRSVDIIGRIGGEEFAVILTNTPRSQAQR 507

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
            AE+IR  +E  P   +Q    +TVSIG+ + +       ++ + ++  AD  LY++K +
Sbjct: 508 TAERIRLAIETSPEFTKQSLPKITVSIGIATNQP-----PENLDAIICRADKNLYQAKSN 562

Query: 301 GRNRTS 306
           GRNR  
Sbjct: 563 GRNRIE 568


>UniRef50_Q21PN7 GGDEF domain n=1 Tax=Saccharophagus degradans 2-40
           RepID=Q21PN7_SACD2
          Length = 565

 Score =  245 bits (625), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 54/230 (23%), Positives = 98/230 (42%), Gaps = 10/230 (4%)

Query: 83  FVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQV 142
             +   + +    + +     +  +  Q  SA+L      +    V        + +++ 
Sbjct: 343 LQSTVSDHIRTIQNALSTFKQAQPAPSQSLSAQLKALMDRVKT--VEEESEKSRAQLEEQ 400

Query: 143 ALRADFDFLTQVYSRSGLYEALKSPS---LKQTQHLTVMLLDIDYFKSINDNYGHECGDK 199
             +A  D LT + +R    E          +    LT+ + D+D+FK IND +GH+ GDK
Sbjct: 401 RYKATHDPLTSLPNREAYNERAFHELHRFKRYGHPLTLAVCDLDHFKKINDTFGHQAGDK 460

Query: 200 VLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQK 259
           VL + A+ +   + +   VAR GGEEF + +P  +      + +K+R  +   PF ++  
Sbjct: 461 VLKLVAQVVSTRLRNVDFVARYGGEEFVLVMPETDAEQAKTVLDKMRAAIAKTPFRFKDS 520

Query: 260 TLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
            + +T+S G+   R       D        AD  LY +K +GRN+     
Sbjct: 521 PVTITMSFGIVQFRGE-----DSVESAFARADKALYEAKANGRNQCVIAP 565


>UniRef50_B4VK28 GGDEF domain protein n=1 Tax=Microcoleus chthonoplastes PCC 7420
           RepID=B4VK28_9CYAN
          Length = 331

 Score =  245 bits (625), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 58/272 (21%), Positives = 110/272 (40%), Gaps = 16/272 (5%)

Query: 48  IASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFS 107
           I  +         F   A +            ++T +     +     +     +  P  
Sbjct: 57  IILLDAMMPVMDGFTCCAQLQERFGQKCPPVLMITGLNNQESVDRAFEAGATDYITKPIH 116

Query: 108 IPQMFSARLGIATMAICPIMVSFSVAA-------INSLMKQVALRADFDFLTQVYSRSGL 160
              +      +         +   +         +  + +++    D D LTQ+ +R   
Sbjct: 117 WAVLRQRVRRLLHTHWVMAELHRKIEQERVLKAKLEEMNQELQRLVDLDGLTQIANRRAF 176

Query: 161 YEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIV-GDKG 216
            +AL+    +  +    L+++L DID+FK+ ND YGH+ GD+ L   A  ++K       
Sbjct: 177 DQALQQEWKRLAREQAPLSLILCDIDFFKAYNDTYGHQAGDECLKQVADILRKAAKRPAD 236

Query: 217 LVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY--LTVSIGVGSGRA 274
           +VAR GGEEF V +P+ +    + +AE IR  ++ +    +   +   +T+S GV     
Sbjct: 237 VVARYGGEEFVVILPNTSLRGAMQVAESIRSKLKSRAIVHEGSGVSKFVTLSCGVA---G 293

Query: 275 SYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
                    ++L+ EAD  LY++K +GR+R  
Sbjct: 294 VIPPPKTTPDRLIAEADQALYKAKVEGRDRVV 325


>UniRef50_Q0BZW4 Response regulator PleD n=1 Tax=Hyphomonas neptunium ATCC 15444
           RepID=Q0BZW4_HYPNA
          Length = 455

 Score =  245 bits (625), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 62/252 (24%), Positives = 105/252 (41%), Gaps = 16/252 (6%)

Query: 61  FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT 120
             L A              L+       + +          +  P    ++       A 
Sbjct: 212 LKLIAHFKMNPVTRSISVILICDPHDKAKALRGLEIGASDMITIPIDRQEL-------AA 264

Query: 121 MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTV 177
                   +  +  +   + +    +  D LT +++R  +    E     + +  Q L++
Sbjct: 265 RIRTQTRRTRYIDILRQRVDRGLELSVIDQLTGLHNRRYMNGQLEQFMQRAARGNQPLSL 324

Query: 178 MLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVD 237
           M+ DID+FK++ND +GH+ GD VL    + ++  V    +V R GGEEF V +P+     
Sbjct: 325 MMTDIDHFKAVNDTHGHQAGDDVLREIGKRLRANVRPTDVVCRTGGEEFVVLMPNTPGDL 384

Query: 238 GLLMAEKIRKGVELQPFTWQQKT--LYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLY 295
               AE+IRK V  + F     +  L +TVS GV + + +     D  + LM  ADT LY
Sbjct: 385 ACAAAERIRKAVAAEEFPVLGGSQNLRITVSAGVSTLQGA----GDTTDDLMHRADTALY 440

Query: 296 RSKKDGRNRTST 307
           ++K  GRNR  +
Sbjct: 441 QAKTGGRNRVES 452


>UniRef50_C6BU46 Diguanylate cyclase n=1 Tax=Desulfovibrio salexigens DSM 2638
           RepID=C6BU46_DESAD
          Length = 490

 Score =  245 bits (625), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 61/175 (34%), Positives = 93/175 (53%), Gaps = 6/175 (3%)

Query: 138 LMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGH 194
           +  ++  RA+ D LT+VY+R    E L     +  +    L+++++D+DYFK++ND YGH
Sbjct: 311 MFNKIKTRANRDGLTRVYNRRSFDERLVEEFKRHQRLNTELSLLMVDLDYFKAVNDTYGH 370

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
             GD VL   AR  +K       +AR GGEEF + +P        ++AE+IR  +E    
Sbjct: 371 MAGDMVLEKVARMFEKTFRSTDFIARYGGEEFVILLPHTREDQAEMLAERIRAKIESCAM 430

Query: 255 TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
           T+Q K+  +T SIGV S R   L       +++ +AD  LY +K  GRNR     
Sbjct: 431 TYQDKSFNITASIGVSSVRPGSLEKDT---EIVRKADEALYDAKMQGRNRVVVSP 482


>UniRef50_Q2IX34 Diguanylate cyclase n=5 Tax=Rhodopseudomonas palustris
           RepID=Q2IX34_RHOP2
          Length = 350

 Score =  245 bits (625), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 54/188 (28%), Positives = 94/188 (50%), Gaps = 7/188 (3%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLL 180
             +++   V  I    +++   A  D +T +++R             + +  + L+ +++
Sbjct: 143 GRMLIYSDVTDIVRNAEELERLATTDGMTGIFNRRHFLTLADREWARARRYGRPLSCLMI 202

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DID+FKSIND++GH+ GD ++   A+  +    D  ++AR+GGEEFA+ +P  +    L 
Sbjct: 203 DIDHFKSINDDFGHQVGDDMIVHLAKLARDCKRDCDVLARIGGEEFALLLPETDLPQALA 262

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           +AE++R  V          ++  TVSIG  +  A+     D  + LM  AD  LY +K  
Sbjct: 263 VAERLRGEVAASSLLMASGSVRATVSIGAATSAATI----DGISDLMRAADRALYEAKHG 318

Query: 301 GRNRTSTM 308
           GRNR    
Sbjct: 319 GRNRVVCH 326


>UniRef50_Q5P7Y3 Putative uncharacterized protein n=1 Tax=Aromatoleum aromaticum
           EbN1 RepID=Q5P7Y3_AZOSE
          Length = 313

 Score =  244 bits (624), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 62/211 (29%), Positives = 98/211 (46%), Gaps = 9/211 (4%)

Query: 103 GSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYE 162
           GS F I    ++  G     +  I +   +     L  ++   A  D LT + +R    E
Sbjct: 106 GSEFPIELTVASWFGEDRR-LSFIGIIRDITERKRLEAELRQLATTDPLTGILNRRRFTE 164

Query: 163 ALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVA 219
                  +  +    LT+++LDID+FK IND +GH  GD+V+   A      + +  ++ 
Sbjct: 165 LTTQEIHRAHRLRHPLTLIMLDIDWFKRINDAFGHTVGDRVIQSLASACASELREIDILG 224

Query: 220 RMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTL-YLTVSIGVGSGRASYLT 278
           R+GGEEFAV +P +     L +AE++R+ VE    T     +   T S+GV   +     
Sbjct: 225 RLGGEEFAVVLPELGASGSLEVAERLRQKVEGLQITLNDGRIVRFTCSLGVAVLK----D 280

Query: 279 LTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
                + L+V AD  LYR+K+DGRN      
Sbjct: 281 TDQSPDTLLVRADNALYRAKRDGRNCVRAAS 311


>UniRef50_Q0A5N6 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Alkalilimnicola
           ehrlichii MLHE-1 RepID=Q0A5N6_ALHEH
          Length = 419

 Score =  244 bits (624), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 57/210 (27%), Positives = 92/210 (43%), Gaps = 11/210 (5%)

Query: 103 GSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYE 162
           G+ F + Q  +         +  +     +     + +++   A  D LT + +R    +
Sbjct: 217 GALFYLEQSITPVRADQGQVVRYVATGKDITERVRMEEELKRAATTDALTGLANRLSFEQ 276

Query: 163 ALKS---PSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVA 219
            L+       +    L++++ D+D+FK++ND +GHE GD VL   A  +   V     VA
Sbjct: 277 LLERDYERCRRYGGALSLLMFDLDHFKAVNDAHGHEAGDAVLQALAGLVLANVRTADTVA 336

Query: 220 RMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTL 279
           R GGEEF V +P         +AEK+R+ V    F        +T S GV + R      
Sbjct: 337 RWGGEEFMVLLPETPLAAAGELAEKLRERVAAHRFPHGA---PVTASFGVCALR-----D 388

Query: 280 TDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
            D    L+  AD  LYR+K  GR+R   + 
Sbjct: 389 DDTCRTLVRRADEALYRAKHLGRDRVECLS 418


>UniRef50_B4UA43 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Hydrogenobaculum
           sp. Y04AAS1 RepID=B4UA43_HYDS0
          Length = 610

 Score =  244 bits (624), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 54/187 (28%), Positives = 91/187 (48%), Gaps = 11/187 (5%)

Query: 125 PIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLD 181
            +     +     L + +  ++  D LT +Y+R  L + L+     + +  + L+V++ D
Sbjct: 432 AVFTFVDITKEKELSELLLKQSIEDTLTGIYNRRYLKDKLERHVNLAKRYERPLSVIMFD 491

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           ID+FK IND +GH+ GDKVL   ++ + + + +  + AR GGEEF +  P     D  ++
Sbjct: 492 IDFFKHINDTFGHDVGDKVLIAISKVVSENIRNTDIFARYGGEEFIIVAPETTKEDAKIL 551

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
           AEK+R  +    F      + +T S GV S         D    L+   D  LY +K+ G
Sbjct: 552 AEKLRSLIRNLHFEEG---INVTCSFGVVSL-----EKPDTKETLLKRVDNALYEAKRTG 603

Query: 302 RNRTSTM 308
           RNR   +
Sbjct: 604 RNRVVVL 610


>UniRef50_Q31EI0 Diguanylate cyclase (GGDEF domain) n=1 Tax=Thiomicrospira crunogena
           XCL-2 RepID=Q31EI0_THICR
          Length = 620

 Score =  244 bits (624), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 52/184 (28%), Positives = 91/184 (49%), Gaps = 10/184 (5%)

Query: 127 MVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDID 183
           ++   +        Q+      D LT VY+R      L+    +  +     ++  +DID
Sbjct: 438 VLMTDITEEEHYKSQLEHLIIHDELTGVYNRHYFNRTLEQEIKRHQRYQSPFSMAFMDID 497

Query: 184 YFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAE 243
           +FK IND YGH+ GD VL   A++I  ++    +  R+GGEEF + +P  +  + L+++E
Sbjct: 498 HFKMINDTYGHDVGDAVLVSLAKNISSLLRSTDVFCRVGGEEFVIMMPETSLENALIISE 557

Query: 244 KIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           +IR  VE    + +     +T+S+G+    +      D+       AD  LY++K++GRN
Sbjct: 558 RIRSTVEG--ISSKDVPEKITISMGLVELNSW-----DNVQSFYKRADEALYKAKENGRN 610

Query: 304 RTST 307
           R  T
Sbjct: 611 RIET 614


>UniRef50_Q21NS3 Diguanylate cyclase n=5 Tax=Alteromonadales RepID=Q21NS3_SACD2
          Length = 319

 Score =  244 bits (624), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 51/197 (25%), Positives = 90/197 (45%), Gaps = 7/197 (3%)

Query: 117 GIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQ 173
            I  +      V+ +   I +   Q+   +  D LT + +R       E       +   
Sbjct: 127 HICLIVYDVTEVAVNRLQIQAANLQLHEISRTDGLTGLLNRKTWELDAEQEYKRFKRHEH 186

Query: 174 HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSV 233
             ++++ DID+FK+IND+YGH  GD+V+   A  ++  + D  +  R GGEEF + +   
Sbjct: 187 PCSLVMFDIDHFKNINDSYGHPAGDEVIRQTAAAVKSCIRDIDIAGRYGGEEFTIVLSDT 246

Query: 234 NPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTC 293
           +    L++AE+IR  ++     ++   +  TVS+GV          T      +  AD  
Sbjct: 247 DTEGALVVAERIRNQIQELTVHYEDFAIQFTVSLGVAQLTQQMTNRT----AWIDCADKA 302

Query: 294 LYRSKKDGRNRTSTMRY 310
           LY++KK+GRN +     
Sbjct: 303 LYQAKKNGRNNSVVYTP 319


>UniRef50_Q3JE99 Response regulator receiver modulated diguanylate cyclase n=2
           Tax=Nitrosococcus oceani RepID=Q3JE99_NITOC
          Length = 661

 Score =  244 bits (624), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 62/275 (22%), Positives = 110/275 (40%), Gaps = 14/275 (5%)

Query: 46  SVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSP 105
             +        G+ +      +            +LT +    E + +  +  D  +  P
Sbjct: 366 CQLVIYEHRLPGANSMKFCRSLREMKCGRQIYLIVLTGMVSGGEAIRIFEAGADDHIAKP 425

Query: 106 FSIPQMFSARLGIATMAICPIM-------VSFSVAAINSLMKQVALRADFDFLTQVYSRS 158
           F+   + +   G   +             V   +A +    +++   A  D LT + +R 
Sbjct: 426 FNYEVLQARVGGGERLIRLREEAEQEREAVRGYLADLAVANRRLGQMAMTDSLTGLPNRR 485

Query: 159 GLYEALKS---PSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDK 215
              E ++       +     + +++D+D+FK +ND YGHE GD VL   A   +      
Sbjct: 486 YAMERMEQAWAEYERNQTPFSCLVMDLDFFKRVNDQYGHEIGDSVLLEIANVFRGSARSS 545

Query: 216 GLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRAS 275
            ++ R+GGEEF V  P     +   +AE++R+ VE   +T    T  L+VSIG+ +    
Sbjct: 546 DIICRLGGEEFLVVCPHTVATEAFQVAERLRRAVEEHSWTMLDSTSVLSVSIGLAASSEG 605

Query: 276 YLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRY 310
                D    L   AD  LY++K++GRNR      
Sbjct: 606 MQHWND----LYRLADQALYQAKRNGRNRVCMAPS 636


>UniRef50_A5D1G5 Hypothetical signaling protein n=1 Tax=Pelotomaculum
           thermopropionicum SI RepID=A5D1G5_PELTS
          Length = 343

 Score =  244 bits (624), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 70/317 (22%), Positives = 132/317 (41%), Gaps = 24/317 (7%)

Query: 14  VLIVPCMLTLAIPGVLPRFKAEQMMPAIAL-----IVSVIASVVIGGAGSLAFPLPALIW 68
           VL +   L     G     +    +P   L      V++  +  I G  +    + A + 
Sbjct: 20  VLAMVPSLVAVAVGYRFAVQGFARLPVEILWGHYETVNITRASAISGFVAAVLVIAASLP 79

Query: 69  CAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFS--------------- 113
            AV    ++T  L  ++   + +   +  I  ++ S   I  +                 
Sbjct: 80  LAVIIARKLTHPLELLSEGADRIARGDYGITFNLRSNLEIEALAENFNKMSLKLKEEREN 139

Query: 114 ARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLK 170
               +A +      +S     +  +  ++ L +  D LT  Y+R  +   L+     + +
Sbjct: 140 LFRQVALLEEQKREISVQKEELARVNSRLELLSITDPLTGAYNRRYIISQLEQELAVAAR 199

Query: 171 QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAV 230
               L+++++DID+FK +ND +GH+ GD+VL    + +   +    ++ R GGEEF V  
Sbjct: 200 HGLPLSLIMIDIDHFKKVNDTHGHQVGDEVLKDVVKVLSGCIRTADVLGRYGGEEFVVIA 259

Query: 231 PSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDD-FNKLMVE 289
           P     + L++AE++R  V   PF      L LT+S+GV +         +   ++L+  
Sbjct: 260 PFTGFQEALVLAERLRDTVSRWPFETTYGFLKLTISLGVTTFNGKEEHYHNSLIDRLLAR 319

Query: 290 ADTCLYRSKKDGRNRTS 306
           AD  +Y++K  GRN  S
Sbjct: 320 ADEEMYKAKAQGRNLVS 336


>UniRef50_C0QQU4 Response regulator receiver modulated diguanylate cyclase n=1
           Tax=Persephonella marina EX-H1 RepID=C0QQU4_PERMH
          Length = 359

 Score =  244 bits (623), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 79/312 (25%), Positives = 132/312 (42%), Gaps = 26/312 (8%)

Query: 9   QFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAG------SLAFP 62
           +F      V  ++ L +        AE  +  I +I+ +   ++ GG           +P
Sbjct: 51  EFIVATGAVLNLILLKVSDGKLIRVAENFI-LIGMIILLTGIIIHGGIANTAIYWIYTYP 109

Query: 63  LPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMA 122
           L +      R        +T +   V + ++    I     SP  I Q  SA + I  +A
Sbjct: 110 LLSFFLKGNRVGLFWN--ITLIVVIVILAVLNKLNIVPIPYSPDEIRQALSAYVVIMVLA 167

Query: 123 ICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVML 179
                     +A+ S  +++   A  D LT  ++R  L++ L+    +  +   HL++++
Sbjct: 168 YVFE------SALLSSYEKIKKLATTDPLTGAFNRYQLFKKLEEEIERSKRYGNHLSLIM 221

Query: 180 LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGL 239
            DID FKSIND YGH  GD+VL +    I+  +     + R GGEEF +  P +N     
Sbjct: 222 FDIDNFKSINDTYGHNIGDQVLKITIDTIKNHIRKTDTLGRFGGEEFMIICPGINDEGAR 281

Query: 240 LMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKK 299
            +AEKIRK V+        +   +T+S+GV           +     + +AD  LY +KK
Sbjct: 282 NIAEKIRKLVKDIKVEGIPE---ITISVGVAEYFP-----DESITDFIKKADIALYSAKK 333

Query: 300 DGRNRTSTMRYG 311
            G+NR       
Sbjct: 334 KGKNRVEIYSSE 345


>UniRef50_UPI0001AEC0DE GGDEF domain protein n=1 Tax=Alteromonas macleodii ATCC 27126
           RepID=UPI0001AEC0DE
          Length = 329

 Score =  244 bits (623), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 52/177 (29%), Positives = 91/177 (51%), Gaps = 7/177 (3%)

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLYEALKSPSL---KQTQHLTVMLLDIDYFKSINDN 191
           +  L +++   +  D LT +Y+R    E          ++ +  T ++LDID+FK IND 
Sbjct: 151 MEHLNEELKTASRVDGLTGLYNRRYWQERFDEMHKLCVRREKPSTALMLDIDHFKRINDT 210

Query: 192 YGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVEL 251
           YGH+ GDKV+ + A  I++ V +  L  R GGEEFA+ +   +  D  ++AE+IR+  + 
Sbjct: 211 YGHQAGDKVIKMLAALIKRCVRETDLAGRYGGEEFAIILNDSSVEDAKIVAERIRQLAQR 270

Query: 252 QPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
                + +++  TVS+G+      +          +  AD  LY +K++GRN+    
Sbjct: 271 LVVEHEGESISFTVSLGLAQFSPDFKGAM----AWLECADQALYEAKENGRNQYRIY 323


>UniRef50_C4XKN6 Putative signaling protein n=2 Tax=Desulfovibrio magneticus RS-1
           RepID=C4XKN6_DESMR
          Length = 629

 Score =  244 bits (623), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 57/203 (28%), Positives = 94/203 (46%), Gaps = 6/203 (2%)

Query: 112 FSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEA---LKSPS 168
           FS       ++      +  +     + +++   A  D LT + +R    E    L   +
Sbjct: 419 FSVFKDETGISTGIFAAARDITERKIMEERLKEMATTDSLTGLNNRQHFLEHSSILFEMA 478

Query: 169 LKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAV 228
            +   +L++ L DID+FK +ND +GHE GD VL   ++          ++ R+GGEEFAV
Sbjct: 479 KRHKANLSIALFDIDHFKQVNDTWGHEAGDLVLRELSKLALNCFRSSDIIGRIGGEEFAV 538

Query: 229 AVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMV 288
            +P  +  + +L +E+ RK VE   F ++   L +TVSIG+     +  T     N L  
Sbjct: 539 IMPETDKEEAILASERFRKIVESTRFEYENDLLSITVSIGIAQFNPNTNT---TINDLTK 595

Query: 289 EADTCLYRSKKDGRNRTSTMRYG 311
            +D  LY +K +GRN        
Sbjct: 596 ISDDALYTAKANGRNMVFCANDQ 618


>UniRef50_B9Z0Y0 Diguanylate cyclase n=1 Tax=Lutiella nitroferrum 2002
           RepID=B9Z0Y0_9NEIS
          Length = 528

 Score =  244 bits (623), Expect = 4e-63,   Method: Composition-based stats.
 Identities = 72/288 (25%), Positives = 123/288 (42%), Gaps = 19/288 (6%)

Query: 30  PRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVE 89
               AE    ++ L+++++A V+I   G L   L +          ++  L   VT  + 
Sbjct: 248 RTAAAESRRLSLQLVIAIVAGVLI--YGWLTLWLGSNTVRHALRASELAILPGAVTTMLA 305

Query: 90  IVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFD 149
                  V        F++   F    G           +  V  +     ++A  A  D
Sbjct: 306 TTWTFYWV--------FALIAAFVGFFGYRMFTYWLDSSTRLVNELAEANSKLAHLARTD 357

Query: 150 FLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFAR 206
            LT + +R  L EAL+    +  ++    +++LLDID+FK +ND YGH+ GD V+    +
Sbjct: 358 TLTGLPNRRALEEALEQQLQRSRRNGEQASLVLLDIDHFKVVNDRYGHDAGDAVIRALGK 417

Query: 207 HIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVS 266
            + + + +  +  R GGEEF V + +V+       AE++R  VE       +  +  T+S
Sbjct: 418 AMSETIRNVDVAGRWGGEEFLVVLANVDEEGAAAFAERLRTRVESSTVAHGELHVRYTIS 477

Query: 267 IGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEV 314
           +GV      +          +  AD  LYR+K DGRNRT+  +   E 
Sbjct: 478 LGVAPLSTPHR------EAWLKRADEALYRAKLDGRNRTAIAQARGEA 519


>UniRef50_Q2BML0 Putative diguanylate cyclase (GGDEF domain) n=1 Tax=Neptuniibacter
           caesariensis RepID=Q2BML0_9GAMM
          Length = 577

 Score =  244 bits (623), Expect = 4e-63,   Method: Composition-based stats.
 Identities = 76/306 (24%), Positives = 131/306 (42%), Gaps = 22/306 (7%)

Query: 17  VPCMLTLAIPGVLPRFKAEQMMPAIALIVSVI------------ASVVIG-GAGSLAFPL 63
           +   + L +P   PR      +    L+   I             +  IG    +L   +
Sbjct: 270 LFARVFLELPSRFPRLNLSFNLLGGVLLFCGILFLLLDDVLSLLYTAFIGIVPFALLMII 329

Query: 64  PALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAI 123
                C          L   V   +  V+ A +V  I          +    L  A +  
Sbjct: 330 AGACACLNGVKEARYFLGAAVFAMISAVITAFTVSGIVEYKAIGFHAVEYGMLIEAVLFA 389

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLL 180
             +   F +     +  Q    AD D LT +Y+R G  + ++     + +  + L +++L
Sbjct: 390 LALAYQFRINQEEKVAAQ--QLADRDQLTGLYNRRGFDKVMEPVFGNAYRHHRELCLLVL 447

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DID+FK+IND +GH  GD VL+  A+ +Q  +    L+AR GGEEF + +P  N ++ + 
Sbjct: 448 DIDHFKAINDRHGHGYGDLVLTDLAKVLQHELRAGDLIARWGGEEFLLLLPETNHMEAVT 507

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           +AE++ + +  +         + TVSIG+   +   +     F +L+VEAD  LYR+K+ 
Sbjct: 508 LAERLIRNISNREVEGDGVQEHYTVSIGIAELKPPIV----SFKQLLVEADKHLYRAKET 563

Query: 301 GRNRTS 306
           GRN+  
Sbjct: 564 GRNKAC 569


>UniRef50_A7BV03 Sensor protein n=2 Tax=Beggiatoa sp. PS RepID=A7BV03_9GAMM
          Length = 866

 Score =  244 bits (623), Expect = 4e-63,   Method: Composition-based stats.
 Identities = 69/263 (26%), Positives = 115/263 (43%), Gaps = 29/263 (11%)

Query: 48  IASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFS 107
           +  + +       F +   +    +Y      +LT +T +   +   +   D  V  PF 
Sbjct: 619 VILLDVMMPDMTGFEVCQQLRKTPQYELIYIIMLTALTDSKYKIEGLDKGADDYVTKPFD 678

Query: 108 IPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP 167
           I ++ +        AI                      A  D LT+VY+R+     L   
Sbjct: 679 ISELLARIRVGERTAIK------------------KREATIDGLTKVYNRNYFDMYLAQE 720

Query: 168 ---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGE 224
              + +  + L++++ DID FK+IND YGH  GD VL  F + I +      LVAR GGE
Sbjct: 721 VSRAKRYKRELSLIITDIDLFKNINDTYGHLTGDTVLQEFTQIIMQQCRRSDLVARFGGE 780

Query: 225 EFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFN 284
           EF + +P      G ++AE++ + ++   F   Q+  ++T S GV S          D  
Sbjct: 781 EFIILLPETPLKGGTIVAERMCQRIDAHIF---QEVEHITASFGVASL-----ITDRDGR 832

Query: 285 KLMVEADTCLYRSKKDGRNRTST 307
           +L+  AD+ LY++KK+GRN+   
Sbjct: 833 ELLRRADSALYQAKKNGRNQVVV 855


>UniRef50_Q74AN9 Response regulator n=1 Tax=Geobacter sulfurreducens
           RepID=Q74AN9_GEOSL
          Length = 301

 Score =  244 bits (623), Expect = 4e-63,   Method: Composition-based stats.
 Identities = 68/237 (28%), Positives = 116/237 (48%), Gaps = 16/237 (6%)

Query: 75  PQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAA 134
                LLT   G  +++   ++  D  VG PFS+ ++  AR+ +    +         + 
Sbjct: 75  LPYILLLTAKNGTDDVIRGLDAGADDYVGKPFSLGEL-RARIQVGRRTV------ELHSR 127

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDN 191
           +    + +  +A  D LT V +R  + + L+    +  +    L++ +LDID+FK +ND 
Sbjct: 128 LQETQEALNHQATHDPLTGVMNRRAIIDHLEKELSRVKRDGGSLSIGILDIDHFKRVNDR 187

Query: 192 YGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVEL 251
           YGH+ GD+VL      +  ++ D  L+ R+GGEEF V  P     D   + E++R  +  
Sbjct: 188 YGHQTGDEVLCGCVGVLGGLLRDYDLLGRLGGEEFLVVAPGTG-DDCNHLYERLRAAIAS 246

Query: 252 QPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
             FT + K + +TVSIGV +        T   ++L+  AD  LYR+K+ GR+R    
Sbjct: 247 TKFTSRAKPVSVTVSIGVAACDG-----TAGLDELLAAADDALYRAKRSGRDRVVQA 298


>UniRef50_B8DJ36 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfovibrio
           vulgaris str. 'Miyazaki F' RepID=B8DJ36_DESVM
          Length = 698

 Score =  244 bits (623), Expect = 4e-63,   Method: Composition-based stats.
 Identities = 60/184 (32%), Positives = 88/184 (47%), Gaps = 7/184 (3%)

Query: 130 FSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPS---LKQTQHLTVMLLDIDYFK 186
             V        ++   A  D LT V +R      L+  +    +  + L+V+LLD D+FK
Sbjct: 495 LDVTDQVEDTLRLEQLATTDELTGVANRRHFMARLEDEAARAQRYGRPLSVLLLDADHFK 554

Query: 187 SINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIR 246
           SIND +GHE GD VL      +   + +  L+ R+GGEEF V +P       L  AE+IR
Sbjct: 555 SINDTWGHEAGDMVLRHITDVMGLSLRENDLIGRLGGEEFGVLLPETAQERALRTAERIR 614

Query: 247 KGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
             VE  P   +   +  TVS+G    R +     D  + L+  AD  L R+K++GRNR  
Sbjct: 615 AAVEDAPVAVRDVWVGCTVSVGAAEYRGA----NDSLDDLIRRADHMLMRAKEEGRNRVC 670

Query: 307 TMRY 310
             + 
Sbjct: 671 AQQA 674


>UniRef50_Q6ALC0 Putative uncharacterized protein n=1 Tax=Desulfotalea psychrophila
           RepID=Q6ALC0_DESPS
          Length = 652

 Score =  243 bits (622), Expect = 4e-63,   Method: Composition-based stats.
 Identities = 62/187 (33%), Positives = 97/187 (51%), Gaps = 8/187 (4%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH----LTVML 179
             +     +       +++   A  D LT + +RS L+E  ++   +Q       L++++
Sbjct: 468 GVVWTIDDITTKRQSREKLQRLATTDSLTGLCNRSQLFEIAEAELERQRHSSEHNLSLVM 527

Query: 180 LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGL 239
           LDIDYFK IND +GH  GD VL  FA   +K + D  + AR+GGEEF + +P  +    L
Sbjct: 528 LDIDYFKKINDAHGHAAGDLVLKAFADIGRKYLRDVDVFARIGGEEFIILLPGTDIKVAL 587

Query: 240 LMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKK 299
            +AE+ R  VE  P    +K +  TVS GV +       +   F +++ EAD+ LY +K+
Sbjct: 588 KIAERFRALVEKNPVMVNEKEIAFTVSFGVTAWNG----IEQTFEEVLHEADSALYVAKE 643

Query: 300 DGRNRTS 306
            GRNR  
Sbjct: 644 KGRNRVE 650


>UniRef50_C1A5L7 Putative two-component response regulator n=1 Tax=Gemmatimonas
           aurantiaca T-27 RepID=C1A5L7_GEMAT
          Length = 491

 Score =  243 bits (622), Expect = 4e-63,   Method: Composition-based stats.
 Identities = 62/199 (31%), Positives = 98/199 (49%), Gaps = 8/199 (4%)

Query: 112 FSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---S 168
                 + T A+  I  +  V +  +   ++   A  D LTQ+ +R  L E + +    +
Sbjct: 294 LEFAQAVITAAVAVIQRAQMVESTMADNARLEQLAQTDPLTQLLNRRALTERITAEMERA 353

Query: 169 LKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAV 228
           L+    L ++++D+D+FK +ND YGH  GD VL    + +   +    + AR GGEEF V
Sbjct: 354 LRYDSTLALLMIDLDHFKKVNDTYGHLVGDDVLRDVGQLLGHTIRGSDITARYGGEEFLV 413

Query: 229 AVPSVNPVDGLLMAEKIRKGVELQPFTWQQ--KTLYLTVSIGVGSGRASYLTLTDDFNKL 286
            +P  +    +  AE+IR  +E  PF      + L LT SIGV    A+ +   ++   L
Sbjct: 414 LLPETDDAGAVAFAERIRVAMEEHPFARDSMAEPLKLTASIGVAVFPAARI---ENVEDL 470

Query: 287 MVEADTCLYRSKKDGRNRT 305
              AD  LYR+K +GRNR 
Sbjct: 471 FARADAALYRAKAEGRNRV 489


>UniRef50_Q21VE2 Diguanylate cyclase n=1 Tax=Rhodoferax ferrireducens T118
           RepID=Q21VE2_RHOFD
          Length = 398

 Score =  243 bits (622), Expect = 5e-63,   Method: Composition-based stats.
 Identities = 70/300 (23%), Positives = 125/300 (41%), Gaps = 15/300 (5%)

Query: 16  IVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTP 75
               +L   +   L   +   ++  IA  ++V+  +V   AG L    P      V    
Sbjct: 108 TAAILLFWVLMTGLIFDRRGIVIGTIAASMAVLGLIVAENAGWLR---PPFYDVGVTQWV 164

Query: 76  QVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAI 135
             T L  F +G    +               +  ++   +    ++      +   V  +
Sbjct: 165 TFTALFGFTSGLTYYINQGTKSA-----LALARKEIEQRKQAEQSLKAANEELHLRVFEV 219

Query: 136 NSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNY 192
             L  ++  +A  D LT +Y+R  L +AL      + +    LT ++ DID+FK +ND+Y
Sbjct: 220 QRLQVELHEQAIHDPLTGLYNRRYLSDALAREIIQAKRANSSLTFVMADIDHFKFVNDSY 279

Query: 193 GHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQ 252
           GH  GD+VL   A  ++K      +  R GGEEF +  P  +       AE+I++     
Sbjct: 280 GHLAGDEVLVQVASLLKKHARGSDIACRYGGEEFLLVFPGTSLELAHKRAEEIQQNCAAL 339

Query: 253 PFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGE 312
               + K + + +S GV +           + +++V+AD  LY+SK +GRN+ +  R  E
Sbjct: 340 SIQHEGKNIAVMLSFGVAAY----PDHGQQWEQIIVKADKALYQSKCNGRNQVTIFRDEE 395


>UniRef50_B2V6Y8 Diguanylate cyclase n=1 Tax=Sulfurihydrogenibium sp. YO3AOP1
           RepID=B2V6Y8_SULSY
          Length = 492

 Score =  243 bits (622), Expect = 5e-63,   Method: Composition-based stats.
 Identities = 63/233 (27%), Positives = 104/233 (44%), Gaps = 12/233 (5%)

Query: 78  TCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINS 137
           T L+TF+       +    +I     + F +    S  + I+++    I+++  +  I  
Sbjct: 266 TILMTFMLIKSFNNISIGYLISYEADTTFKVFSK-SFYIMISSLLFIMIIINIFIINIIK 324

Query: 138 LMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGH 194
           L      +A  D LT +++RS +   ++    +  +    ++++L DID+FK IND YGH
Sbjct: 325 LKNVAEKKAITDKLTGLFNRSIIDTLIQVEIERAKRNNKPISILLFDIDHFKKINDTYGH 384

Query: 195 ECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPF 254
           + GD  L   A   ++ +     V R GGEEF   +P  +      +AEKIR  +E   F
Sbjct: 385 DKGDYALKTIAEIARRTLRKSDYVLRWGGEEFLAILPETDLDGATKVAEKIRSNIENYNF 444

Query: 255 TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
                   +TVSIGV   +          +  +  AD  LY +K  GRNR   
Sbjct: 445 KDIG---RVTVSIGVTMLKIGEP-----LDNAIKRADEALYAAKNKGRNRVEV 489


>UniRef50_B6BK11 Ggdef/pas/pac-domain containing protein n=1 Tax=Campylobacterales
           bacterium GD 1 RepID=B6BK11_9PROT
          Length = 464

 Score =  243 bits (622), Expect = 5e-63,   Method: Composition-based stats.
 Identities = 57/202 (28%), Positives = 100/202 (49%), Gaps = 8/202 (3%)

Query: 110 QMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSL 169
           + F + + I       I     + A  +L +Q+  +A  D+LT++++R      L+    
Sbjct: 266 EFFGSPIKITEDTTNIIWNILDITAKKNLQEQLETQATTDYLTELHNRRYFTSRLEEEVA 325

Query: 170 KQTQ----HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEE 225
           +  +      ++++ D+D FK IND  GH  GD VL +FA  ++K +    +  R+GGEE
Sbjct: 326 RIKRDKKVTSSLLMFDLDKFKLINDTLGHLMGDVVLKIFADILKKNLRKSDIAGRIGGEE 385

Query: 226 FAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNK 285
           FA+ +PS N  +  ++A +IR+ V  +       ++  TVSIG+ +      +   + + 
Sbjct: 386 FAMILPSTNIREAKVLANRIREEVSNKKTIIDGNSINFTVSIGLTAI----ASDDANSDS 441

Query: 286 LMVEADTCLYRSKKDGRNRTST 307
               ADT LY +K  GRNR   
Sbjct: 442 AFARADTALYMAKGKGRNRVEV 463


>UniRef50_B0C2A6 Diguanylate cyclase (GGDEF domain), putative n=3 Tax=Acaryochloris
           marina MBIC11017 RepID=B0C2A6_ACAM1
          Length = 420

 Score =  243 bits (622), Expect = 5e-63,   Method: Composition-based stats.
 Identities = 59/201 (29%), Positives = 104/201 (51%), Gaps = 9/201 (4%)

Query: 118 IATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKS---PSLKQTQH 174
           I         +  +   ++   KQ++L A+ D LT + +R    E L+     + ++ Q 
Sbjct: 223 IQAKLYAQQALEATNKKLDEANKQLSLIANHDALTGLANRRRFDEYLQQIWKQTQREQQP 282

Query: 175 LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIV-GDKGLVARMGGEEFAVAVPSV 233
           L++++ DID+FK  ND YGH  GD  L   A+ I + +     LVAR GGEEFA+ +P+ 
Sbjct: 283 LSLLICDIDFFKQYNDTYGHLEGDICLRTVAQKIHQTIVRPLDLVARFGGEEFAIVLPNT 342

Query: 234 NPVDGLLMAEKIRKGVELQPFTWQQKTLY--LTVSIGVGSGRASYLTLTDDFNKLMVEAD 291
           +   G ++AE++R  ++      +  ++   +TVSIG  + R+   T     + L+  AD
Sbjct: 343 DLEGGQVVAERLRMIIQKSQLPHRGSSVSEFVTVSIGAATVRSHPHT---SVSSLISRAD 399

Query: 292 TCLYRSKKDGRNRTSTMRYGE 312
             LY++K+ GR++   +   E
Sbjct: 400 QALYQAKQSGRDQVVALSITE 420


>UniRef50_C6P3N4 Diguanylate cyclase n=1 Tax=Sideroxydans lithotrophicus ES-1
           RepID=C6P3N4_9PROT
          Length = 387

 Score =  243 bits (622), Expect = 5e-63,   Method: Composition-based stats.
 Identities = 79/315 (25%), Positives = 137/315 (43%), Gaps = 20/315 (6%)

Query: 11  STGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGA--GSLAFPLPALIW 68
           S+ VLI+  +         PR++    +    LI +++   + G    G + F L  ++ 
Sbjct: 77  SSYVLILAAVYEFQQRSA-PRWQYFVPVILTLLIAAILIDDIHGRFIWGGIVFVLQLVLI 135

Query: 69  CAVRYTPQVT------CLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMA 122
            +     + T       LL      V +VL   S++ +S     + P+       +  ++
Sbjct: 136 ASELLRNRATHTGRAWRLLLAGIAIVVVVLGLRSLVAMSGQFILAQPETGGVPNWVQVLS 195

Query: 123 ICPIM-------VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKS-PSLKQTQH 174
              +M       + F +       ++V   A  D LT V +R  L +  +   + +  + 
Sbjct: 196 FVAVMASSLLGSIGFLLMVKERTDREVLHLAMTDSLTGVPNRRALMDYAERAMAQRGGRS 255

Query: 175 LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVN 234
           + ++++D D+FK IND YGH  GD+VL    R +Q+ +    L+ R GGEEF V  P  +
Sbjct: 256 VALLMIDADHFKRINDTYGHPVGDEVLRQLTRLLQQRLRGGDLLGRYGGEEFCVVAPDAD 315

Query: 235 PVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCL 294
               L +AE +R+ V       +Q  L +TVSIG+    A           ++ EAD  L
Sbjct: 316 AEGALKLAESLRESVASAVLDTEQGKLSITVSIGIAHSTAD---AGRALKDILAEADIAL 372

Query: 295 YRSKKDGRNRTSTMR 309
           Y +KK GRN+  +  
Sbjct: 373 YSAKKGGRNQVVSFS 387


>UniRef50_A7N081 Putative uncharacterized protein n=6 Tax=Vibrio RepID=A7N081_VIBHB
          Length = 354

 Score =  243 bits (621), Expect = 5e-63,   Method: Composition-based stats.
 Identities = 59/189 (31%), Positives = 94/189 (49%), Gaps = 7/189 (3%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPS---LKQTQHLTVMLL 180
             I     V   + L K++   ++ D LT V +R      L       L+ +Q L+ +++
Sbjct: 150 WVIWSVRDVTKTHLLEKRLKELSETDELTGVLNRRAFLTRLDKAMSSHLRPSQTLSCIMI 209

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DID+FK IND  GH  GD+V+   A+  Q+ +     + R+GGEEFAV + + + +    
Sbjct: 210 DIDHFKEINDQVGHFSGDQVIHHVAKICQRAIRGSDFIGRLGGEEFAVILVNTSAIQAYD 269

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           +AE+IR+ ++  P       +  TVSIGV        + T+    LMV AD  +Y SK  
Sbjct: 270 VAERIREAIQNAPCKVDGIEISTTVSIGVAEYDEQVSSTTE----LMVNADKAMYYSKHS 325

Query: 301 GRNRTSTMR 309
           GRN+ +   
Sbjct: 326 GRNQVTLHH 334


>UniRef50_Q30SY9 Diguanylate cyclase (GGDEF domain) n=1 Tax=Sulfurimonas
           denitrificans DSM 1251 RepID=Q30SY9_SULDN
          Length = 611

 Score =  243 bits (621), Expect = 6e-63,   Method: Composition-based stats.
 Identities = 57/170 (33%), Positives = 92/170 (54%), Gaps = 11/170 (6%)

Query: 141 QVALRADFDFLTQVYSRSGLYEALKSPS---LKQTQHLTVMLLDIDYFKSINDNYGHECG 197
           ++   A  D LT  Y+R  + E +K      ++ +++L++++ DID+FK +ND YGH+ G
Sbjct: 449 ELERLASIDKLTGAYNRRMIDEFMKKEIFLHVRDSKNLSLIMADIDHFKLVNDTYGHQAG 508

Query: 198 DKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ 257
           D VLS   R I   +    +  R GGEEF V  P+ +    L++A+KIR+ +E   F   
Sbjct: 509 DAVLSDVGRIISSTIRKSDIFGRYGGEEFIVICPNTSSQQALILAQKIREEIENFHFAEV 568

Query: 258 QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
                 T+S+GV +  A+     D+   ++  AD  LY +KK+GRNR   
Sbjct: 569 GHK---TISLGVATLIAN-----DEVENIIKRADDALYIAKKEGRNRVVL 610


>UniRef50_Q31GI5 Diguanylate cyclase (GGDEF domain) n=1 Tax=Thiomicrospira crunogena
           XCL-2 RepID=Q31GI5_THICR
          Length = 532

 Score =  243 bits (621), Expect = 6e-63,   Method: Composition-based stats.
 Identities = 62/210 (29%), Positives = 96/210 (45%), Gaps = 12/210 (5%)

Query: 104 SPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEA 163
              +   +    +    + I  ++V F +       + +   A  D LT + +RS    A
Sbjct: 330 KLITENFLQHLLINEFLLLIISLLVFFFIRNQIRQRRLLHKMAKTDNLTGLPNRSIFKRA 389

Query: 164 LKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVAR 220
           L     +  +    L+++  DID+FK IND YGH  GDKVL   AR+I+  +  K + AR
Sbjct: 390 LNENIKRSNKKQWPLSLIFFDIDHFKKINDTYGHLVGDKVLKKVARNIEDGLTHKDIFAR 449

Query: 221 MGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLT 280
            GGEEF + +P+ +  D   +AE++R+ +E          + +T S GV   R       
Sbjct: 450 WGGEEFVILLPNTDLQDAEKVAERLRQKLEAMT----DFDITITSSFGVSDLRP-----D 500

Query: 281 DDFNKLMVEADTCLYRSKKDGRNRTSTMRY 310
           D     M   D  LYRSK+ GRNR +    
Sbjct: 501 DTAESFMQRGDEMLYRSKEQGRNRVTANSP 530


>UniRef50_B7VQN9 GGDEF family protein n=1 Tax=Vibrio splendidus LGP32
           RepID=B7VQN9_VIBSL
          Length = 405

 Score =  243 bits (621), Expect = 7e-63,   Method: Composition-based stats.
 Identities = 71/334 (21%), Positives = 137/334 (41%), Gaps = 29/334 (8%)

Query: 2   LADWFSEQFSTGVL---IVPCMLTLAIPGVLPRFKAEQMMPAIALIV--SVIASVVIGGA 56
           ++ W S+  S   +       + +L      P   +  +   + +++   +  ++     
Sbjct: 61  ISPWLSKITSNMAIAGGFASMVFSLTQLRQSPSLYSVCVFLGLPVVIVTLIYFTLYDAST 120

Query: 57  GSLAFPLPALIWCAVRYTPQVT------------CLLTFVTGAVEIVLVANSVIDI---S 101
            +    +   I      +  V              LL  V  A  I ++    I +   +
Sbjct: 121 NARVITMSFYITLCTVASVLVIKTGTVADVKAALVLLMSVFSAHSIFMLVRIWITLKEPN 180

Query: 102 VGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY 161
           +        +      I  + +  I  +++      LM+ +   +  D LTQ+Y+R  + 
Sbjct: 181 IDDFLQASSIHQLAFIITAILLSTIGFTYNWLLNARLMQSLYSSSMKDSLTQLYNRRAMN 240

Query: 162 EALKSPSLK---QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLV 218
           E L+   ++       L+V++LDID+FK +ND +GH+ GD+VL      +Q  +    + 
Sbjct: 241 EMLRREWMRSVRHNHPLSVIILDIDHFKQVNDQHGHQTGDQVLKKIGIILQHNLRAADIP 300

Query: 219 ARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLT 278
            R GGEEF + +P     +   +AEK+R  +E   F W+Q++  LT S G+    A    
Sbjct: 301 FRYGGEEFLIVLPDTRIGEACKVAEKLRIIIEETKF-WRQQSANLTASFGLSELWAE--- 356

Query: 279 LTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGE 312
             D    ++  AD  LY +K++GRN    +   +
Sbjct: 357 --DKVPSMIKRADEALYYAKENGRNTVCALTDEQ 388


>UniRef50_C8X007 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8X007_DESRD
          Length = 531

 Score =  243 bits (621), Expect = 7e-63,   Method: Composition-based stats.
 Identities = 77/318 (24%), Positives = 135/318 (42%), Gaps = 19/318 (5%)

Query: 4   DWFSEQF-STGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSV--IASVVIGGAGSLA 60
           +W    F  +GV++   +L   +  V+P  + + +      + +V     +V     +  
Sbjct: 211 NWTPMSFALSGVILALGILCFRVLDVVPIARKQVIDAMSEGVAAVDNSGRIVDANPAACQ 270

Query: 61  FP---LPALIWCAVR--YTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSAR 115
           F    +  LI    R  + P    L+    G+  + +                 ++  AR
Sbjct: 271 FLQSDVAGLIGMRARDVFAPWYATLVVMEPGSGSVEIRLPYGFKEMSWLEIERSEIRDAR 330

Query: 116 LGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQT 172
                     +++   V+       ++   A  D LT +Y+R   +E  +     + + +
Sbjct: 331 ----GRLWGQLVLMRDVSERKEAESRLLQMAATDELTGLYNRRRFFELARGEFNRAKRYS 386

Query: 173 QHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPS 232
             +T++LLDIDYFK IND YGH+ GD  L      I   +    ++AR+GGEEF   +P 
Sbjct: 387 SPMTILLLDIDYFKRINDEYGHDAGDTALRCIVSMIASQLRSLDVLARLGGEEFVALLPE 446

Query: 233 VNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADT 292
            +  D   +AE+IR  +E       + TL++TVSIGV         + +    L+  AD 
Sbjct: 447 THQFDAERIAERIRSEIESTAINLFETTLFVTVSIGVAGYSKEMQDVGE----LINRADE 502

Query: 293 CLYRSKKDGRNRTSTMRY 310
            +YR+K+DGRN+      
Sbjct: 503 AMYRAKRDGRNQVCLATP 520


>UniRef50_Q47C76 PAS:GGDEF n=1 Tax=Dechloromonas aromatica RCB RepID=Q47C76_DECAR
          Length = 548

 Score =  243 bits (621), Expect = 7e-63,   Method: Composition-based stats.
 Identities = 62/191 (32%), Positives = 99/191 (51%), Gaps = 8/191 (4%)

Query: 128 VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDY 184
           +S  +  I    K++   + FD LT +++R   +   K    + +++   L+VM+LDID+
Sbjct: 362 ISTDITPIKHYQKELERLSQFDELTNLFNRRHFFSLAKHELNRSSRYRSKLSVMMLDIDH 421

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEK 244
           FK IND +GH+ GD VL+   + I   + D  +  RMGGEEFA+ +P  +     +MAE+
Sbjct: 422 FKRINDGHGHKTGDLVLANIGKQIGDSLRDSDIAGRMGGEEFAILLPETDLEQASIMAER 481

Query: 245 IRKGVELQPFTW-QQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           +RK V          +TL  T+SIG+ +     +    D   L+ +ADT LY +K  GRN
Sbjct: 482 LRKQVAETWLDIGDGRTLNCTLSIGLATKSDQQI----DLENLLHQADTALYAAKNSGRN 537

Query: 304 RTSTMRYGEEV 314
           + S        
Sbjct: 538 KVSCADRNRPA 548


>UniRef50_A9L0C9 Diguanylate cyclase n=2 Tax=Shewanella baltica RepID=A9L0C9_SHEB9
          Length = 466

 Score =  243 bits (620), Expect = 7e-63,   Method: Composition-based stats.
 Identities = 71/307 (23%), Positives = 136/307 (44%), Gaps = 15/307 (4%)

Query: 10  FSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPAL-IW 68
           +  G +++P + +LA+   L        +P +    S    ++      L + L AL + 
Sbjct: 152 WLWGFVLIPVLCSLAL--ALFATWGSHWLPILIAKNSYK-QLLHSPYALLVWGLNALALV 208

Query: 69  CAVRYTPQVTCLLTFVTGAVEIVL---VANSVIDISVGSPFSIPQMFSARLGIATMAICP 125
           C +R       L T+++ A+   L                +   ++ S+   +  +    
Sbjct: 209 CMIRRARSNNVLYTWLSVALLASLIDVTLTLFAGARFSLGWYAARISSSVSSMVLLCALL 268

Query: 126 IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDI 182
             V+    A     + +  ++  D LT +++R  L   L      + +  + L +++LD+
Sbjct: 269 WEVNRLYVATQRANESLYQQSVKDTLTGLFNRRYLESQLAIHIDHAKRHKEPLCLLVLDV 328

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIV-GDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           D+FK+ ND +GH  GD  L   A+ +++ +      +AR GGEEF V +P  +  DG+ +
Sbjct: 329 DHFKAFNDQHGHLAGDDCLVTVAKQLEQSLYRPADFIARYGGEEFIVVLPHTDAKDGMQI 388

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
           AE++R  V  +   +Q + L +T+SIG    R       +    L++ AD+ LY++K  G
Sbjct: 389 AERLRLNVSAEKIEYQGQLLSVTISIGCAVLR----HSEETAQSLLIAADSALYQAKAAG 444

Query: 302 RNRTSTM 308
           RN     
Sbjct: 445 RNCVKVA 451


>UniRef50_B8KJJ5 GGDEF domain protein n=2 Tax=unclassified Gammaproteobacteria
           RepID=B8KJJ5_9GAMM
          Length = 540

 Score =  243 bits (620), Expect = 7e-63,   Method: Composition-based stats.
 Identities = 68/267 (25%), Positives = 115/267 (43%), Gaps = 23/267 (8%)

Query: 56  AGSLAFPLPALIWCAVRYTPQVTCLLTF---VTGAVEIVLVANSVIDISVGSPFSIPQMF 112
              L   +P  +W     T  +  L      +    E  +V  +V    +G  F+  + F
Sbjct: 269 VLILLLSVPVFLWTLSSVTSPLKNLAAIFRRLAAGSEESVVDAAVTKDEIGDLFNAAEAF 328

Query: 113 SARLGIATMAICPIM---------VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEA 163
                     +             V+     + +  +++   A  D LT  ++R  L +A
Sbjct: 329 RRENIRERELLADYRELSRTLEAKVTQRTRELEAKNEELDHLASVDKLTDTFNRRALDKA 388

Query: 164 LKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVAR 220
           L +    + +  + L+++L+DID FK +ND YGH  GDKVL   ++ I++ +    ++ R
Sbjct: 389 LLAELERADRYQRPLSILLMDIDLFKQVNDEYGHLTGDKVLVTLSQTIRENLRASDILGR 448

Query: 221 MGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLT 280
            GGEEF V  P  +      +AEK+R+ +E   F   +    +T+SIG+           
Sbjct: 449 WGGEEFLVICPETDLEQARNVAEKVRQAIEGTDFELGK---TITISIGLSVL-----IEG 500

Query: 281 DDFNKLMVEADTCLYRSKKDGRNRTST 307
                L+ EAD  LY++K  GRNR  T
Sbjct: 501 TSAESLVAEADKALYQAKSQGRNRVCT 527


>UniRef50_Q5NP17 Diguanylate cyclase with beta propeller sensor n=3 Tax=Zymomonas
            mobilis RepID=Q5NP17_ZYMMO
          Length = 1008

 Score =  243 bits (620), Expect = 7e-63,   Method: Composition-based stats.
 Identities = 63/260 (24%), Positives = 114/260 (43%), Gaps = 17/260 (6%)

Query: 60   AFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIA 119
            A  +P +I+  +        L   + G  + +L  +  +++            +  + + 
Sbjct: 754  AGSVPFVIYSHLPAGHFTFALRATIPGIKQPILETHFPVNVEYRWYEYRFVKIALIIILV 813

Query: 120  TMAI---------CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLK 170
                           +M++     +     ++   A+ D LT + +R    E  +    +
Sbjct: 814  LFLYDLISNQIRKLRLMITNKTLELQETNLRLKELANTDELTGLLNRRAFTEMFEKNCAQ 873

Query: 171  QTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFA 227
             ++     +V +LDID+FK INDN GH  GD V+   A+ I + +  +   AR GGEEF 
Sbjct: 874  FSKTKDQFSVFILDIDFFKKINDNEGHLAGDAVIQYIAQKITENIRQQDFAARYGGEEFV 933

Query: 228  VAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLM 287
            + +P+ +      +A +I   +  +P  +Q + + +TVSIGV   +       DD N L+
Sbjct: 934  IMLPNADMETTCQVASRIGNAISEKPVPYQGREIPVTVSIGVAVMK-----ENDDANSLL 988

Query: 288  VEADTCLYRSKKDGRNRTST 307
              AD  LY +K  GRNR S+
Sbjct: 989  ERADERLYMAKNQGRNRVSS 1008


>UniRef50_A0LD73 Diguanylate cyclase n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0LD73_MAGSM
          Length = 513

 Score =  242 bits (619), Expect = 9e-63,   Method: Composition-based stats.
 Identities = 75/243 (30%), Positives = 116/243 (47%), Gaps = 18/243 (7%)

Query: 73  YTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSV 132
           +     C+    +G V  V+      D++V  P+ IP +              +  S SV
Sbjct: 270 HPLGFYCMPVLHSGTVGNVVQLVVEPDMAVMFPYIIPFL-----------QVFLRESSSV 318

Query: 133 AAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKSIN 189
                LM+++   A  D LT + +R  L E  +   + S ++   L+V+++D+D+FK +N
Sbjct: 319 IESKRLMEKLRESALKDPLTGLNNRRFLEEYERTIVASSQRKEMFLSVLMMDLDHFKMVN 378

Query: 190 DNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGV 249
           D +GH+ GD VL   A  + +      LV R GGEEF V + +  P  G  +AEKIR+ V
Sbjct: 379 DTHGHQVGDAVLKSLAGVLMQQTRASDLVVRYGGEEFMVVLQNERPHMGNQIAEKIRETV 438

Query: 250 ELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
           E          L  T+SIGV        T   DF+ ++ +AD  LYR+K+ GRNR  +  
Sbjct: 439 ERLKINVPGGCLQKTISIGVAEF----PTDGTDFDDVVEKADMALYRAKEQGRNRVISHS 494

Query: 310 YGE 312
             E
Sbjct: 495 ASE 497


>UniRef50_A5V1I0 Diguanylate cyclase with GAF sensor n=2 Tax=Roseiflexus
           RepID=A5V1I0_ROSS1
          Length = 681

 Score =  242 bits (619), Expect = 9e-63,   Method: Composition-based stats.
 Identities = 55/182 (30%), Positives = 89/182 (48%), Gaps = 6/182 (3%)

Query: 137 SLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYG 193
            L  +    A  D LT V++R   +E ++    +  +    L ++++D+D+FKS+ND YG
Sbjct: 500 HLFAEARRHATIDELTGVWNRRTFFENVRREFQRSQRTLHPLAILMIDVDHFKSVNDTYG 559

Query: 194 HECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP 253
           H  GD+VL   A   +  +    ++ R GGEEFAVA+P  +      +AE++R  VE  P
Sbjct: 560 HAAGDQVLRGVAERCRNQLRVIDIIGRYGGEEFAVALPETDIHAAGQIAERLRIAVERAP 619

Query: 254 FTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEE 313
           F     ++ LT+S+G               + ++  AD  LY +K+ GRN      Y   
Sbjct: 620 FVTDYGSISLTISVGAAVYHPDDHV---TLDAVIDRADRALYIAKRSGRNSVRVWSYPAT 676

Query: 314 VV 315
            V
Sbjct: 677 TV 678


>UniRef50_A4SM80 GGDEF domain protein n=2 Tax=Aeromonas RepID=A4SM80_AERS4
          Length = 432

 Score =  242 bits (619), Expect = 9e-63,   Method: Composition-based stats.
 Identities = 53/191 (27%), Positives = 95/191 (49%), Gaps = 9/191 (4%)

Query: 127 MVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDID 183
            +   ++    L++++ + A  D LT + +R    E +K       +    ++++LLDID
Sbjct: 246 AILRDISERARLVEELKVAATTDPLTGIANRRRFDELVKQEVQRCQRFGHTMSLLLLDID 305

Query: 184 YFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAE 243
           +FK +ND +GH+ GD+ +    R I K + +  ++ R GGEEF + +P  +       AE
Sbjct: 306 HFKQVNDTHGHQQGDQAILSLVRRIAKQLREVDILGRWGGEEFIILLPETSLDLAWASAE 365

Query: 244 KIRKGVELQPFTWQ-QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           +IR  +  +         + LTVSIG+ + +       D+ + ++  ADT LY +KK GR
Sbjct: 366 RIRLAIASESHPLGADIEIPLTVSIGISASQG----PQDNVDNMVRRADTALYLAKKQGR 421

Query: 303 NRTSTMRYGEE 313
           N        E+
Sbjct: 422 NC-CIKEATEQ 431


>UniRef50_Q2BQS0 GGDEF family protein n=1 Tax=Neptuniibacter caesariensis
           RepID=Q2BQS0_9GAMM
          Length = 314

 Score =  242 bits (619), Expect = 9e-63,   Method: Composition-based stats.
 Identities = 56/188 (29%), Positives = 97/188 (51%), Gaps = 7/188 (3%)

Query: 122 AICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVM 178
               I ++ ++     L +++   A+ D +T  Y+R    E++        +     ++ 
Sbjct: 129 IAAVIWLAINITEKKRLEQRLKDLAEKDPMTGAYNRRFFRESIDQHYATFKRYGTTYSLA 188

Query: 179 LLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDG 238
            +DIDYFK +ND +GH+ GD V+     HIQ+ +    L++R GGEEF V  P +N  + 
Sbjct: 189 FIDIDYFKKVNDQFGHDVGDGVICHLVTHIQEQLRTTDLLSRFGGEEFVVLFPHINLDEA 248

Query: 239 LLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSK 298
            L+AE++R  +E+ P+      +  TVSIG+   RA      +    ++  AD+ LY+SK
Sbjct: 249 CLVAERLRATIEMTPYKSINHKVPFTVSIGISEVRAE----DESVEDILKRADSALYQSK 304

Query: 299 KDGRNRTS 306
             GRN+ +
Sbjct: 305 SSGRNKVT 312


>UniRef50_A1TWT4 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Marinobacter
           aquaeolei VT8 RepID=A1TWT4_MARAV
          Length = 407

 Score =  242 bits (619), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 54/197 (27%), Positives = 90/197 (45%), Gaps = 8/197 (4%)

Query: 122 AICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVM 178
            +    +   ++    L  ++   A  D LT V +R      L      + +  + L ++
Sbjct: 210 TMVLEGIILDISDRKQLENELEALATRDSLTGVLNRRECSRVLIEELERARRYNRPLALL 269

Query: 179 LLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDG 238
            +D D+FK IND +GH  GD VL   +  ++  V     + R GGEEF + +P ++  + 
Sbjct: 270 WIDFDHFKEINDTWGHAAGDSVLCSISSLLEDSVRSVDTLGRFGGEEFVLILPEMDVAEA 329

Query: 239 LLMAEKIRKGVELQPFTWQ-QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRS 297
              AE++R+ V  QP   +    + LT+SIGV           D  + L   AD  +YR+
Sbjct: 330 EETAERLRQRVCNQPVALESGHNIRLTISIGVAVF----PDHGDTLDALCAAADKAMYRA 385

Query: 298 KKDGRNRTSTMRYGEEV 314
           KK GRN  +  +  + V
Sbjct: 386 KKQGRNCIAMAQAVQPV 402


>UniRef50_B0SEM7 GGDEF domain protein n=2 Tax=Leptospira biflexa serovar Patoc
           RepID=B0SEM7_LEPBA
          Length = 288

 Score =  242 bits (619), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 69/284 (24%), Positives = 127/284 (44%), Gaps = 20/284 (7%)

Query: 38  MPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVR-------YTPQVTCLLTFVTGAVEI 90
           MPA   ++ +       G  +  F L  L   A+        Y      L T +  A+  
Sbjct: 1   MPATFDLIWLTVLAFGTGHITSFFILGYLGSIALSSMSLDRNYGIYNAFLATVLFSAMGF 60

Query: 91  VLVANSVIDISVGSPFSIPQMFSARLGIATM----AICPIMVSFSVAAINSLMKQVALRA 146
           ++    +  +++  P   P + S  +    +     I   +VS   +++  + +++   A
Sbjct: 61  LVYFEILPSVNILMPTVKPTLMSIFISSILLGGSAFIVNQIVSKLFSSLTDVNQKLLAIA 120

Query: 147 DFDFLTQVYSRSGLYEALKSPSLKQTQ-----HLTVMLLDIDYFKSINDNYGHECGDKVL 201
             D LT + +R   +  L+    ++ +      +  +L D+D FKSIND YGHE GD+VL
Sbjct: 121 MTDPLTGISNRRSFFSNLEIELARKQRSVGPYPIAFLLFDLDLFKSINDTYGHEFGDQVL 180

Query: 202 SVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTL 261
             FA  ++  +  +   AR GGEEF V +P+ +    +++AEKIR       F  + K +
Sbjct: 181 IEFATVLKTSLRKQDFPARWGGEEFLVLLPNTDLDGAIVVAEKIRTSFHSLSFYAKDKRI 240

Query: 262 YLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRT 305
             + S+G+            +   ++ +AD  LY +K++GRN+ 
Sbjct: 241 QCSTSVGISVCN----EQGINPEVVINQADQYLYEAKRNGRNQI 280


>UniRef50_Q2BP61 GGDEF/HAMP domain protein n=1 Tax=Neptuniibacter caesariensis
           RepID=Q2BP61_9GAMM
          Length = 580

 Score =  242 bits (619), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 74/306 (24%), Positives = 124/306 (40%), Gaps = 23/306 (7%)

Query: 22  TLAIPGVLPRFKAEQMMPAIALI--VSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTC 79
           TL     L       + P  +L+     I+ V+I     +AF L + ++           
Sbjct: 273 TLHSAEYLVIRSTFNLTPIYSLMHKFLGISLVIILVVLGIAFFLLSFLFEKWILRRIFRI 332

Query: 80  LLTFVTGAV-------------EIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPI 126
           +      A              E+ L+A+ +  ++        ++  AR  +        
Sbjct: 333 IAALERSAEGDYADQMISDRKDELGLIADHINSMNRRIAHRDVELREARNTLEHRVEERT 392

Query: 127 M-VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLK---QTQHLTVMLLDI 182
             +   V A     +++   A  D LT+V +R    +  +    +     + L ++LLDI
Sbjct: 393 RDLQLEVNARKKAEEELIKLASTDPLTRVLNRRAFDQRSREEIERSHRYNRELAIILLDI 452

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           D+FK IND YGH+ GDKVL   A  I   +     + R GGEEF + +P  +    LL+A
Sbjct: 453 DHFKQINDQYGHQFGDKVLIDVANLIGPSLRAADCLCRHGGEEFIILLPETDEATALLIA 512

Query: 243 EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           E++RK +     T +  +L +T S GV   R        D    +  AD  +Y++K  GR
Sbjct: 513 ERVRKSIAQHKITDRHDSLSITASFGVAVWR----REEGDIQPAVYRADQAMYKAKNSGR 568

Query: 303 NRTSTM 308
           N+    
Sbjct: 569 NKVVAF 574


>UniRef50_C0QC96 Sensory box histidine kinase (GGDEF domain protein) n=1
            Tax=Desulfobacterium autotrophicum HRM2
            RepID=C0QC96_DESAH
          Length = 1268

 Score =  242 bits (619), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 57/210 (27%), Positives = 95/210 (45%), Gaps = 15/210 (7%)

Query: 106  FSIPQMFSARLGIATMAICPIMVSFSVAAINS----LMKQVALRADFDFLTQVYSRSGLY 161
            F+   M+      A +    +  +  ++A N        ++   +  D LT +Y+R  + 
Sbjct: 1066 FNYKNMWRYLFITALLFSGILFWNRKLSAFNRQMAEANAKLEQLSVTDRLTGLYNRMKID 1125

Query: 162  EALKSPS---LKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLV 218
            + L       L+    L+++L+DID FK +ND +GH+ GD VL   A+ + K +    + 
Sbjct: 1126 DTLLEEIGRVLRYNYPLSLILMDIDLFKQVNDTHGHQAGDAVLIQMAKTMDKNIRSTDIC 1185

Query: 219  ARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLT 278
             R GGEEF V  P  +    L +AE +R+ +  Q F      +  T S GV         
Sbjct: 1186 GRWGGEEFMVICPHTDLKGALSLAEHLRESIARQIFPH---VITQTGSFGVAQY-----G 1237

Query: 279  LTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
              D    L+  AD  +Y +K+ GRNR  ++
Sbjct: 1238 NGDSEADLIARADRAMYLAKEGGRNRVESV 1267


>UniRef50_Q31IP8 Diguanylate cyclase (GGDEF domain) with PAS/PAC sensor n=1
           Tax=Thiomicrospira crunogena XCL-2 RepID=Q31IP8_THICR
          Length = 540

 Score =  242 bits (618), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 53/186 (28%), Positives = 100/186 (53%), Gaps = 6/186 (3%)

Query: 132 VAAINSLMKQVALRADFDFLTQVYSRSGLYEALKS---PSLKQTQHLTVMLLDIDYFKSI 188
           +  + SL+ Q+   A  D+LT + +R   +E  +     + +  Q ++++++DID+FK I
Sbjct: 358 MEQLGSLLNQLRDEATKDYLTGLLNRKAFFEQAEQIWLSAKEHHQPISLLMIDIDHFKRI 417

Query: 189 NDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKG 248
           ND++GH+ GD+VL   A    +   ++ LV R GGEEF + + + +    L  A +++K 
Sbjct: 418 NDSFGHDAGDRVLIEVANVFSQNCREEDLVCRYGGEEFIILLENKDEQPTLEFASRLKKV 477

Query: 249 VELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
           ++    + Q + +  ++S+GV +G A  L   +     +  AD  LY++K +GRNR    
Sbjct: 478 IQEMSVSEQGEVIRFSISVGVATGSALEL---NSIETFISHADQALYQAKANGRNRVEVF 534

Query: 309 RYGEEV 314
              E+ 
Sbjct: 535 HAEEKT 540


>UniRef50_Q2BLA2 Putative uncharacterized protein n=1 Tax=Neptuniibacter
           caesariensis RepID=Q2BLA2_9GAMM
          Length = 811

 Score =  242 bits (618), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 57/186 (30%), Positives = 101/186 (54%), Gaps = 5/186 (2%)

Query: 132 VAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSI 188
           +         +   A  D LT + +R      L++    + +  + L++ +LD+D+FK I
Sbjct: 627 LIEEQQTEANLHRLATTDELTSLANRRKFLTTLEAELARAKRYHRELSLCMLDLDHFKRI 686

Query: 189 NDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKG 248
           ND+ GH  GD VL   A+ ++ ++ +  +  R+GGEEFA+ +P  +  D L++AE++R+ 
Sbjct: 687 NDDNGHSAGDSVLVEVAKIMEAMLRESDMAGRIGGEEFAILLPDTSEDDALILAERLREA 746

Query: 249 VELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
           +E     +Q  TL LT SIGV S       +     +L+  AD C+Y +K++GRN  S +
Sbjct: 747 IESLEIKYQAHTLKLTTSIGVASLNQMPEIVQAS--ELLSAADDCMYYAKQNGRNLVSNV 804

Query: 309 RYGEEV 314
           R  +++
Sbjct: 805 RTTQQL 810


>UniRef50_A6LYL1 Diguanylate cyclase n=1 Tax=Clostridium beijerinckii NCIMB 8052
           RepID=A6LYL1_CLOB8
          Length = 568

 Score =  242 bits (618), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 76/314 (24%), Positives = 133/314 (42%), Gaps = 22/314 (7%)

Query: 11  STGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCA 70
           ST VL +   L   I   +P       +  + L++S+  S +I    +       +I   
Sbjct: 260 STWVLFIYSYLD--IKKHMPILNNFFKLSILFLVLSLYISKIIPDGFTYDILYLQMILVG 317

Query: 71  VRYTPQVTCLLTFVTGAV----EIVLVANSVIDISVGSPFSIPQMFSAR-----LGIATM 121
           +     +     F  G++     I ++    I   +GS   +     A            
Sbjct: 318 LYILISIYSYFKFGMGSIYYLVGIFILFTGFIIYILGSYGLLEWNIFAFSTCYPAASIET 377

Query: 122 AICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKS---PSLKQTQHLTVM 178
            +  I +   +     +  ++ L    D LT +Y+R    E + +      K+   ++++
Sbjct: 378 LLFTIGIIKQIKHEKEVNTKLQLEVITDKLTNIYNRRYFEETVVNKILQLEKEKSLVSML 437

Query: 179 LLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDG 238
           +LDID+FK +ND YGH  GD VLS  A  I++ +  + ++ R GGEEF   +P  +  + 
Sbjct: 438 VLDIDHFKKVNDTYGHSTGDLVLSETAMIIKQCLRKEDILVRWGGEEFVAVLPFTDSKES 497

Query: 239 LLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSK 298
            ++AE IR  +E   F +  K   +TVSIG+         + +DF+     AD  LY +K
Sbjct: 498 TIIAETIRLSIENHKFKFVNK---ITVSIGIAE-----KDVVEDFHSWFRRADNALYNAK 549

Query: 299 KDGRNRTSTMRYGE 312
           ++GRN        E
Sbjct: 550 ENGRNTVCICYTNE 563


>UniRef50_Q30SV7 Diguanylate cyclase (GGDEF domain) with PAS/PAC sensor n=1
           Tax=Sulfurimonas denitrificans DSM 1251
           RepID=Q30SV7_SULDN
          Length = 659

 Score =  242 bits (618), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 56/186 (30%), Positives = 94/186 (50%), Gaps = 11/186 (5%)

Query: 126 IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDI 182
           I ++  ++ + ++ K +   A+ D LT +Y+R    E +K     S +   +L+++++DI
Sbjct: 482 ISIARDISELKAMNKTLEKMANTDNLTGIYNRRKFEEIIKIEMERSARYNSNLSLIMIDI 541

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           D+FK IND YGH+ GD V+      + K +    +  R GGEEF V  P     +  ++A
Sbjct: 542 DHFKRINDTYGHDEGDNVIRKTVEIVSKNIRHLDVFVRWGGEEFIVLCPQTESKNASILA 601

Query: 243 EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           EK+R  +E   +    K   +T S GV S         +D +  +   DT LY +K +GR
Sbjct: 602 EKLRVAIESVNYETLGK---ITCSFGVTSY-----IKDEDKSSFIKRLDTALYSAKDEGR 653

Query: 303 NRTSTM 308
           NR   +
Sbjct: 654 NRVVAL 659


>UniRef50_B0C0K6 Diguanylate cyclase (GGDEF) domain protein n=3 Tax=Acaryochloris
           marina MBIC11017 RepID=B0C0K6_ACAM1
          Length = 449

 Score =  242 bits (618), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 55/189 (29%), Positives = 92/189 (48%), Gaps = 8/189 (4%)

Query: 128 VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDY 184
            +     +    + +   A  D LT+VY+R      L     +  +    ++++++DID+
Sbjct: 248 FNLMANQLEQSQQDLYRLATLDGLTEVYNRREFNRWLLVEIERSQRGEHPVSLIMVDIDH 307

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEK 244
           FK +ND YGH+ GD  L   A+ +Q+ V    +V R GGEEF V +P     D  ++AE+
Sbjct: 308 FKRLNDTYGHQAGDLALCEVAQLLQREVRPGDIVCRYGGEEFGVILPKATSADSWVIAER 367

Query: 245 IRKGVELQPFTWQ-QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRN 303
           IR  +  +      Q+ + +T S+GV +         D   +L+ +AD  LY +K  GRN
Sbjct: 368 IRLAIAEKSVVLPSQQHIDMTASLGVATY----PDHADCKERLVKQADQALYTAKYQGRN 423

Query: 304 RTSTMRYGE 312
           R  +    E
Sbjct: 424 RVHSAEVNE 432


>UniRef50_B7K319 Response regulator receiver modulated diguanylate cyclase n=2
           Tax=Cyanothece RepID=B7K319_CYAP8
          Length = 660

 Score =  242 bits (618), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 62/207 (29%), Positives = 104/207 (50%), Gaps = 10/207 (4%)

Query: 109 PQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP- 167
            +  S    +A      I  S  +  +    +++A  A+ D LTQV +R    E L    
Sbjct: 452 EEEMSLLESVAAQLGIAIAHSHLLEQLKEANEKLAALANLDGLTQVANRRHFDEILAQRW 511

Query: 168 --SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIV-GDKGLVARMGGE 224
               ++ Q L++++ D+DYFK  ND YGH+ GD+ L   A+ I K V     LVAR GGE
Sbjct: 512 KQCAREKQPLSLIMCDVDYFKRYNDFYGHQMGDECLIKVAQTIAKTVQRPGDLVARWGGE 571

Query: 225 EFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTL--YLTVSIGVGSGRASYLTLTDD 282
           EFAV +P+ +      +A+ IR+ V+      +   +   +++S+G+ +      TL ++
Sbjct: 572 EFAVILPNTDVNGVKYIAQSIREQVQSLAIIHEDSPIKNQVSISLGIATIIPPAKTLENN 631

Query: 283 FNKLMV----EADTCLYRSKKDGRNRT 305
              L+     +AD  LY++K+ GR+R 
Sbjct: 632 HESLIKALIAQADQALYQAKEQGRDRI 658


>UniRef50_A8I8X7 GGDEF domain protein n=2 Tax=cellular organisms RepID=A8I8X7_AZOC5
          Length = 510

 Score =  242 bits (618), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 56/257 (21%), Positives = 106/257 (41%), Gaps = 11/257 (4%)

Query: 58  SLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLG 117
               P  +    +     +   + + V     IV+V   +  ++           +  + 
Sbjct: 248 MTTTPQGSFTSTSEIDRVKRYYVFSRVGDLPLIVVVGVGMDAVTAPWQAQWLAGAATSVV 307

Query: 118 IATMAICP-IMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYE---ALKSPSLKQTQ 173
           +  + +   + +   +     + ++    +  D LT + +R    E        + +Q  
Sbjct: 308 LCLLILGAAVALRREMLRRFEIEQEFLRLSQTDSLTGLPNRRHFDEFGQREWQRAARQRS 367

Query: 174 HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIV-GDKGLVARMGGEEFAVAVPS 232
            + V+++DID+FK +ND  GH  GD+VL   +  I+  +        R GGEEFA+ +P 
Sbjct: 368 SIAVLMVDIDHFKQVNDRIGHPGGDRVLREVSDIIRASLHRPGDFAGRYGGEEFAIILPE 427

Query: 233 VNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADT 292
            +      +AE+IR  +E       +    +TVSIG+    A          ++M+ AD 
Sbjct: 428 TDAPAAAHVAERIRAAIEA---NTAEGVAPVTVSIGLA---AGLAAPKGTLAEMMIAADH 481

Query: 293 CLYRSKKDGRNRTSTMR 309
            LYR+K+ GRNR  +  
Sbjct: 482 ALYRAKETGRNRVVSSH 498


>UniRef50_A8HRM0 Putative diguanylate cyclase n=1 Tax=Azorhizobium caulinodans ORS
           571 RepID=A8HRM0_AZOC5
          Length = 514

 Score =  242 bits (618), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 62/229 (27%), Positives = 105/229 (45%), Gaps = 11/229 (4%)

Query: 89  EIVLVANSVIDISVGSPFSIPQMFSARLGIATMAIC-PIMVSFSVAAINSLMKQVALRAD 147
            +V    S+ DI +   + +    +A L +   +I   +++   +   + L  ++   + 
Sbjct: 272 LVVATGQSIRDIFLPWRYRVLVGTAAVLTVGFASIAIALVLRHDLMRRSRLQAELLQLSL 331

Query: 148 FDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGHECGDKVLSVF 204
            D LT + +R   ++       +  +    + V+++DID FK +ND  GH  GD VL   
Sbjct: 332 TDDLTGIANRRRFFDVAIREWQRAQRLGSPVAVLMIDIDRFKLLNDRLGHAAGDAVLQAI 391

Query: 205 ARHIQKIV-GDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL 263
           A+ I+  +     L AR GGEEF   +P  +       AE+IR  VE            +
Sbjct: 392 AQLIRHSLRRPADLAARYGGEEFTAILPDTDMAGAFQTAERIRTQVERDVIRGDH---PV 448

Query: 264 TVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGE 312
           TVSIG+    A+  +  + F  ++  AD  LYR+K+ GRNR    R G+
Sbjct: 449 TVSIGIA---AAIASPNETFENVVAAADRALYRAKESGRNRVMVERIGD 494


>UniRef50_Q21JG3 GGDEF domain n=1 Tax=Saccharophagus degradans 2-40
           RepID=Q21JG3_SACD2
          Length = 603

 Score =  241 bits (617), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 75/312 (24%), Positives = 132/312 (42%), Gaps = 23/312 (7%)

Query: 6   FSEQFSTGVL-IVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIAS---VVIGGAGSLAF 61
           F+ QFST +L I      L              +PA+  +     +    V+       F
Sbjct: 279 FALQFSTDILNIKEFSKLLNRIAKCLMIACVVAIPAVLTMPYAFMAPVMTVLTLTIMPLF 338

Query: 62  PLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATM 121
            +  ++  A  Y P    +L +      +++    V  +   + F+          I  M
Sbjct: 339 FVMGVLRLASGYRPARYFMLAWTALIFSVIVYVLKVFGVLPRTFFTENGFQIG--SIIEM 396

Query: 122 AICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEAL---KSPSLKQTQHLTVM 178
            +  + +   +        ++  ++  D LT++ +R    +        + +  Q L ++
Sbjct: 397 VLLSLALGSRMT-------ELKQQSHTDALTEIGNRRRFDDVFPVEFERAQRNKQPLALL 449

Query: 179 LLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDG 238
           ++DIDYFK +ND +GH+ GD+ L   A  I+ +     L  R GGEEFAV +P  +    
Sbjct: 450 MIDIDYFKKLNDTFGHDAGDQALRAVATTIKTLTRKPMLPCRFGGEEFAVILPRTDSAAA 509

Query: 239 LLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSK 298
            ++AE+IR+ +  +P   ++    +TVS+GV S    Y T       +M  AD CLY +K
Sbjct: 510 KIVAERIRQTIAEKPMAKRE----VTVSVGVASTDMGYFT---SSRAIMNAADECLYLAK 562

Query: 299 KDGRNRTSTMRY 310
           + GRNR      
Sbjct: 563 EMGRNRVCLFSE 574


>UniRef50_A1TTA7 Diguanylate cyclase n=2 Tax=Acidovorax RepID=A1TTA7_ACIAC
          Length = 357

 Score =  241 bits (617), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 73/311 (23%), Positives = 125/311 (40%), Gaps = 16/311 (5%)

Query: 8   EQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAI---ALIVSVIASVVIGGAGSLAFPLP 64
               T + +V   +  A   +L R +    +  I    +  S I + +IG      + L 
Sbjct: 52  SPLLTWLNLVSIGMYAAAYALLQRHRNGAALALIWLEVVGHSAIGTWLIGWNSGFHYYLL 111

Query: 65  ALIWCAV----RYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT 120
             I   V    R       L       V +   +      +   P       +  + +  
Sbjct: 112 MFIPAIVVGRGRRAATPVMLFALFVFYVGMYEFSRRHGAQAPLDPLGQSIAHAFNVAV-V 170

Query: 121 MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQ---TQHLTV 177
            A+      +   ++    +++  +A  D LT + +R  L    +    +     Q  +V
Sbjct: 171 FAMAAYTARYYYGSVLRAERRLEEQACTDPLTGLSNRRRLAGLAQERIAQARAAGQPTSV 230

Query: 178 MLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVD 237
           ++ DID+FK IND +GHE GD+VL   A  +++      L+AR GGEEF + +PS    D
Sbjct: 231 VIADIDHFKRINDTHGHEAGDQVLVHVAELMERSSRAHDLLARWGGEEFLLVMPSCGLGD 290

Query: 238 GLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRS 297
              +AE++R  V   P     + +  ++S+GV   R       +     +  AD  LY S
Sbjct: 291 AQALAERMRAIVAGHPARRDTQAIPASLSLGVAQLRG-----GESLEAAIARADQALYAS 345

Query: 298 KKDGRNRTSTM 308
           K+ GRNR +T 
Sbjct: 346 KEAGRNRVTTA 356


>UniRef50_A0Z7X2 Response regulator n=1 Tax=marine gamma proteobacterium HTCC2080
           RepID=A0Z7X2_9GAMM
          Length = 365

 Score =  241 bits (617), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 52/183 (28%), Positives = 92/183 (50%), Gaps = 11/183 (6%)

Query: 128 VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDY 184
           V      +    +++   A  D LT++ +R  L E L+    + +++   L+++LLDID+
Sbjct: 187 VEERTLELKRANEKLEYLASTDPLTELVNRRRLDEVLEQEFERTSRYQGELSLILLDIDH 246

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEK 244
           FK++ND  GH+ GD+V++      +++        R GGEEF +  P  +  + +  AEK
Sbjct: 247 FKAVNDTRGHQVGDEVIAGVGNIAKQMSRKSDTAGRWGGEEFLIVAPQTSCDNAVAFAEK 306

Query: 245 IRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
           +R  +E   F+     + ++ S GV S         +    ++  AD  LYR+K +GRNR
Sbjct: 307 LRLSIENTEFSSG---VRVSASFGVASL-----ETGETIQLVLKRADEALYRAKHNGRNR 358

Query: 305 TST 307
             T
Sbjct: 359 VET 361


>UniRef50_A8UV88 Putative uncharacterized protein n=1 Tax=Hydrogenivirga sp.
           128-5-R1-1 RepID=A8UV88_9AQUI
          Length = 475

 Score =  241 bits (617), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 59/171 (34%), Positives = 92/171 (53%), Gaps = 8/171 (4%)

Query: 146 ADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLS 202
           A  D LT + +R    E  +     S +  + L+++++DID FKSINDNYGH+ GD VL 
Sbjct: 307 AYTDPLTGLNNRRFFMENARTIIDLSKRYREPLSLLMMDIDNFKSINDNYGHDVGDLVLK 366

Query: 203 VFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY 262
             A  I+K V    + AR GGEEF V +P  +    L++AE+IR            K ++
Sbjct: 367 KLAEVIRKNVRTSDIPARFGGEEFVVLLPRTDEKGALMVAERIRNEFRNSSVKVDGKDIW 426

Query: 263 LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEE 313
            +VSIG+        +  DD + L+ +AD  LY++K+ G++R    R  ++
Sbjct: 427 TSVSIGLSVL-----SEEDDIDSLIKKADEALYQAKRSGKDRVVIYREEDQ 472


>UniRef50_B3QU32 Diguanylate cyclase and serine/threonine protein kinase with TPR
           repeats n=1 Tax=Chloroherpeton thalassium ATCC 35110
           RepID=B3QU32_CHLT3
          Length = 606

 Score =  241 bits (617), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 57/197 (28%), Positives = 98/197 (49%), Gaps = 15/197 (7%)

Query: 121 MAICPIMVSFSVAAINSLMKQVALRADF-------DFLTQVYSRSGLYEALK---SPSLK 170
           + +  + +  + A    L++++  +A+        D LT + +R    E  +     + +
Sbjct: 415 LEVTTLALKEANAENQLLLERLREQAETLERLVTYDGLTGLANRRHFDEQFEYEFRRTRR 474

Query: 171 QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAV 230
             + L++ + DID+FK +NDN+ H+ GD+VL   A   ++ V    LVAR GGEEF    
Sbjct: 475 YKRPLSIAMSDIDFFKKVNDNFSHQVGDEVLKKVASIFRENVRAGDLVARYGGEEFVFIF 534

Query: 231 PSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEA 290
              N    +  AEKIRK +E   ++     L +T+SIGV           D  ++L+  A
Sbjct: 535 TETNKESAIRAAEKIRKAIEDYDWSNVHAGLKVTISIGVAEDAGF-----DGCDELIAAA 589

Query: 291 DTCLYRSKKDGRNRTST 307
           D+ LY +K++GRN+   
Sbjct: 590 DSKLYEAKRNGRNQVRA 606


>UniRef50_B2A6L1 Response regulator receiver modulated diguanylate cyclase n=1
           Tax=Natranaerobius thermophilus JW/NM-WN-LF
           RepID=B2A6L1_NATTJ
          Length = 340

 Score =  241 bits (616), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 64/282 (22%), Positives = 118/282 (41%), Gaps = 19/282 (6%)

Query: 48  IASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFS 107
           +  + I         +   I  +   +     ++T +  +  +     +     +  P  
Sbjct: 59  LILLDIMMPDIDGIEVCKRINDSSHVSDIPVIIVTALNDSGFLERAFQAGAIDFITKPVK 118

Query: 108 IPQMFSARLGIA-------TMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGL 160
             ++ +                +    +  ++  +    K+    A  D LTQ+ +R   
Sbjct: 119 RLELLARVGSAIKLSKEKRMRIVREQELEKTLKLLEETNKKFEKLATIDELTQLANRRLF 178

Query: 161 YEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQ-KIVGDKG 216
            E ++    +  ++   L+++LLDIDYFK+ ND YGH+ GD+ L   A+ ++  ++    
Sbjct: 179 DETMRGEWRRANRNGYNLSIILLDIDYFKNFNDAYGHQAGDECLKAIAKKLKFLMMRPGD 238

Query: 217 LVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY--LTVSIGVGSGR- 273
             AR GGEEFAV +P  +      +AEKIR+G+E          +   +TVS+GV S   
Sbjct: 239 FAARYGGEEFAVILPETDLRGAHSVAEKIRQGIEELKIPHCDSKVAQYVTVSLGVASADL 298

Query: 274 -----ASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRY 310
                       D+   L+  AD  LY++K +GRN  + M+ 
Sbjct: 299 KNCQGGRDQATDDEIKILIEHADEALYKAKDNGRNTIALMQP 340


>UniRef50_A1VA66 Diguanylate cyclase with PAS/PAC sensor n=3 Tax=Desulfovibrio
           vulgaris RepID=A1VA66_DESVV
          Length = 827

 Score =  241 bits (616), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 63/206 (30%), Positives = 102/206 (49%), Gaps = 7/206 (3%)

Query: 107 SIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EA 163
            +     AR          +  +  +    +L   +   A  D LT V +R   +     
Sbjct: 609 PVNVEVHARRIEFEGRFVVLSSARDITERKNLEAALLREATTDPLTGVRNRRQFFVDANR 668

Query: 164 LKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGG 223
             + +L+    L V++LDID+FK++ND YGH+ GD+VL  FA    + +    +  R+GG
Sbjct: 669 EFARALRHDSGLAVLMLDIDHFKNVNDLYGHQAGDEVLRAFAACCVEALRAYDVFGRLGG 728

Query: 224 EEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDF 283
           EEFA  +P+ +P + +  AE++RK VE +   ++   L  TVS+GV S  A+ L     F
Sbjct: 729 EEFAALLPAASPEEAMETAERLRKRVERRSVVYEGTALQCTVSVGVTSLAAADLG----F 784

Query: 284 NKLMVEADTCLYRSKKDGRNRTSTMR 309
           + ++  AD  LY +K  GRNR+    
Sbjct: 785 DDMLRRADRALYAAKDHGRNRSEMAP 810


>UniRef50_C8QVV3 Diguanylate cyclase n=1 Tax=Desulfurivibrio alkaliphilus AHT2
           RepID=C8QVV3_9DELT
          Length = 519

 Score =  241 bits (616), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 60/213 (28%), Positives = 96/213 (45%), Gaps = 13/213 (6%)

Query: 100 ISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAIN---SLMKQVALRADFDFLTQVYS 156
           ++        + F  RL +A      I+       +     L+++    A  D LT + +
Sbjct: 302 LAEIGQIGAEEDFGRRLPVAAGHEIGIIARHFNKLLEVVERLLREKDQLAGTDQLTGLNN 361

Query: 157 RSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVG 213
           R    E L    ++  +    L++++ DID+FK +ND YGHE GD VL   A+ +Q  V 
Sbjct: 362 RRRFKELLDQELIRYRRIPKPLSLLIFDIDHFKRVNDTYGHETGDLVLKEMAQLLQATVR 421

Query: 214 DKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGR 273
                AR GGEEF V +P+      + +AEK+R+ +E   F        +T S GV +  
Sbjct: 422 RTDTPARWGGEEFLVLLPATTAEAAMALAEKLRQAIEEHDFPRVG---RVTASFGVAAFH 478

Query: 274 ASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
                 +     L+   D  LY++K+ GRNR  
Sbjct: 479 DGEQEES----ALLRRVDKALYQAKRQGRNRVV 507


>UniRef50_Q0A9X2 Diguanylate cyclase n=3 Tax=Proteobacteria RepID=Q0A9X2_ALHEH
          Length = 295

 Score =  241 bits (616), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 64/191 (33%), Positives = 104/191 (54%), Gaps = 8/191 (4%)

Query: 127 MVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ----HLTVMLLDI 182
            +   V A  +L +++   A  D LT VYSR  + E  +    ++ +     LT++++D+
Sbjct: 105 ALEKEVQARETLAEELHRLAMMDDLTGVYSRRQVLEVGERELARRRRQGLTPLTLLMMDL 164

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           D+FK IND YGH  GD VL  F+  +++ + +   V R+GGEEF   +P V+   GL +A
Sbjct: 165 DHFKRINDKYGHAAGDTVLVAFSEVLRRNLRESDAVGRLGGEEFLAVLPDVDLQGGLALA 224

Query: 243 EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           E+IR  +      WQ++ + LTVSIGV       L + +  +  ++ AD  LY++K  GR
Sbjct: 225 ERIRSEIAELRIPWQEEAIRLTVSIGVA----GILAVHESLDDTIMRADDALYQAKVAGR 280

Query: 303 NRTSTMRYGEE 313
           NR +    G +
Sbjct: 281 NRVTVAGSGAQ 291


>UniRef50_Q1JWQ3 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfuromonas
           acetoxidans DSM 684 RepID=Q1JWQ3_DESAC
          Length = 648

 Score =  241 bits (616), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 53/189 (28%), Positives = 94/189 (49%), Gaps = 9/189 (4%)

Query: 122 AICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVM 178
            +  +     +  +  L +++   A  D LT   +R  L+   +     + +  + L+V+
Sbjct: 463 LVGMVGTVLDITTMVLLQQKLERLATTDELTGAVNRRQLFIYTDQFCQLAKRYKKALSVI 522

Query: 179 LLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDG 238
             D+D+FK++ND YGH  GD+VL      IQ ++ D  ++AR GGEEF + VP  +    
Sbjct: 523 FYDLDHFKAVNDTYGHAAGDEVLRQITTRIQSMLRDTDILARYGGEEFCILVPETDGDHA 582

Query: 239 LLMAEKIRKGVELQPFTW-QQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRS 297
            L AE+IR+ +          ++L +TVS+GV + +       +  + L+  AD  +Y +
Sbjct: 583 YLFAERIRQRISESSVNLSSGESLQVTVSMGVATYQ-----EDEQGSSLIDRADQGVYEA 637

Query: 298 KKDGRNRTS 306
           K+ GRN   
Sbjct: 638 KRRGRNCVV 646


>UniRef50_B4RZE8 GGDEF domain protein n=2 Tax=Alteromonadales RepID=B4RZE8_ALTMD
          Length = 325

 Score =  241 bits (616), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 51/181 (28%), Positives = 92/181 (50%), Gaps = 7/181 (3%)

Query: 135 INSLMKQVALRADFDFLTQVYSRSGLYEALKSPSL---KQTQHLTVMLLDIDYFKSINDN 191
           +  L +++   +  D LT +++R    E          ++ +  T ++LDID+FK IND 
Sbjct: 148 MEHLNQELKTASRVDGLTGLFNRRYWQERFDEMYKLCVRRDKPSTAVMLDIDHFKRINDT 207

Query: 192 YGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVEL 251
           YGH+ GDKV+ + A  I++ V +  L  R GGEEFA+ +      D  ++AE+IR+  + 
Sbjct: 208 YGHQAGDKVIKMLAALIKRCVRETDLAGRYGGEEFAIILNDSTVEDARIVAERIRQLAQR 267

Query: 252 QPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYG 311
                + +++  TVS+G+    +++          +  AD  LY +K+ GRN+       
Sbjct: 268 LVVEHEGESINFTVSLGLAQFCSAFKGPL----AWLECADKALYDAKESGRNQYRVYDTS 323

Query: 312 E 312
           +
Sbjct: 324 Q 324


>UniRef50_D1TF13 Response regulator receiver protein n=1 Tax=Burkholderia sp.
           CCGE1002 RepID=D1TF13_9BURK
          Length = 531

 Score =  241 bits (616), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 71/230 (30%), Positives = 112/230 (48%), Gaps = 9/230 (3%)

Query: 91  VLVANSVIDISVGSPFSIPQMFSARLGIA---TMAICPIMVSFSVAAINSLMKQVALRAD 147
           ++VA +     V +P+      +A L IA      +   +++F++         +   A 
Sbjct: 289 LIVAIAPAVDDVLAPWQRRSHVAAALTIAFGAVFVVVSWLLAFALRDKQRAQAALLRLAS 348

Query: 148 FDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVF 204
            D LT + +R  L + L      + +  + L+V+ +DID+FK  ND YGHE GD+VL   
Sbjct: 349 TDPLTGLSNRRVLDKRLDDEWMRARRDNRPLSVLFIDIDHFKRFNDTYGHESGDEVLVAV 408

Query: 205 ARHIQKIVGDK-GLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY- 262
           A  I  +      LVAR GGEEFAV +P         +AE+IR+ VE +      +    
Sbjct: 409 ADCIASVARRSVDLVARYGGEEFAVVLPDTTAQGAFAVAEQIRRKVESRVIVRGHEAPQA 468

Query: 263 LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGE 312
           +TVS+G  + R S     +    L+  AD  LY +K +GRNRT + ++ E
Sbjct: 469 VTVSVGCATARPSTADFANGLE-LLAAADAQLYVAKNEGRNRTRSAQWDE 517


>UniRef50_Q48M78 Sensory box-containing diguanylate cyclase, putative n=9
           Tax=Proteobacteria RepID=Q48M78_PSE14
          Length = 459

 Score =  241 bits (616), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 59/215 (27%), Positives = 99/215 (46%), Gaps = 11/215 (5%)

Query: 103 GSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY- 161
           GS F      S    +       + +S  V       +++   A  D LT + +R     
Sbjct: 252 GSLFYAEHSISPLCNLEGTITHYVSISQDVTTRLGREQKLLEIAHSDPLTGLNNRRAAEH 311

Query: 162 --EALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVA 219
             E L   +    +  ++++ DID+FKS+ND YGH  GD+VL+  A  +++ +  + + A
Sbjct: 312 TLERLIDTARISGKPFSLIIGDIDHFKSVNDRYGHPAGDRVLTSVAVILKQRIRLQDVAA 371

Query: 220 RMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTL 279
           R GGEEF + VP  +      +A++IRKGVE            +T+S+GV          
Sbjct: 372 RWGGEEFLILVPDSSLDHAAELADRIRKGVEDLLIPNTG---SVTISLGVAQLSP----- 423

Query: 280 TDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEV 314
            +    L+  AD  LY++K+ GRNR    +  + +
Sbjct: 424 GETAASLIQRADKALYQAKRRGRNRVDIAQADDTI 458


>UniRef50_Q7NZV8 Putative uncharacterized protein n=1 Tax=Chromobacterium violaceum
           RepID=Q7NZV8_CHRVO
          Length = 383

 Score =  241 bits (615), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 60/198 (30%), Positives = 100/198 (50%), Gaps = 10/198 (5%)

Query: 116 LGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH- 174
           L +A      I ++      +   KQ+   A  D LT++ +R    E       +  +H 
Sbjct: 189 LALAQRITRIIAIAL---QRDGHEKQLYRLATQDGLTELNNRRQFIELADREIERSRRHG 245

Query: 175 --LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPS 232
             ++V+++D+D+FK IND+YGH  GD+V+  F++  ++++    L  R+GGEEFA  +P 
Sbjct: 246 SRMSVLMMDLDHFKDINDHYGHAVGDEVIRHFSQVCREVLRASDLCGRLGGEEFAAVLPD 305

Query: 233 VNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADT 292
               D   +AE++R        +    +L  TVSIGV    A       D ++++  AD 
Sbjct: 306 TGLDDARQVAERLRSLASSARLSAVSGSLGYTVSIGVAERHADE----TDIDEVLGRADK 361

Query: 293 CLYRSKKDGRNRTSTMRY 310
            LY++K+DGRNR S    
Sbjct: 362 QLYQAKRDGRNRVSGAAP 379


>UniRef50_A0YVN1 PleD-like protein n=2 Tax=Cyanobacteria RepID=A0YVN1_9CYAN
          Length = 1252

 Score =  241 bits (615), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 54/222 (24%), Positives = 107/222 (48%), Gaps = 11/222 (4%)

Query: 91   VLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDF 150
            ++   + + +   +  +  Q+  A+  +A   +  + ++    A   L ++   ++  D 
Sbjct: 1034 MMAQGNTLGLLYIATLTPGQLTPAKRQLARTVVEHLAIAL---ANVKLQEKFKAQSMRDA 1090

Query: 151  LTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARH 207
            LT +++R  L E+L+    +  +    + ++++DID+FK  ND +GH+ GD+VL   AR 
Sbjct: 1091 LTGLFNRRYLEESLEQEIHRARRNHYSVGIVMIDIDHFKRFNDQFGHDAGDEVLKTVARL 1150

Query: 208  IQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTL-YLTVS 266
            +Q  +    +  R GGEE  + +P  +  D    +E+IR  +E     ++ ++L  +T S
Sbjct: 1151 LQGSIRSSDIACRYGGEELTLILPEASLSDTQARSEQIRYMIEHLQLHYENQSLGSITAS 1210

Query: 267  IGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
             GV           +    ++  ADT LY++K  GRNR    
Sbjct: 1211 FGVACF----PEHGETLEAVLRIADTALYQAKALGRNRVVCA 1248


>UniRef50_C9RM68 Diguanylate cyclase n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RM68_FIBSS
          Length = 566

 Score =  240 bits (614), Expect = 4e-62,   Method: Composition-based stats.
 Identities = 52/190 (27%), Positives = 91/190 (47%), Gaps = 8/190 (4%)

Query: 128 VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDY 184
           V      +    K++ L +  D LTQ+ +R  ++  ++    +  +     +++ +DID+
Sbjct: 374 VKERTYELEQANKKLDLISRTDELTQLPNRRDMHRTIEKEVDRANRFKKAFSIIFIDIDH 433

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEK 244
           FK +ND YGH  GD VL   A  I+ ++    ++AR GGEEF   +P     D   +AE+
Sbjct: 434 FKDVNDTYGHAAGDAVLKSVASTIRSLLRKYDVLARYGGEEFLTLLPETELKDAAHVAER 493

Query: 245 IRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
            RK +E Q   +  + + +T+++GV    +          + +  AD  LY  K+ GRNR
Sbjct: 494 FRKQIENQTIFFGGQEIKVTITLGVAQFDSGLGA-----ERCIQLADKALYEGKEHGRNR 548

Query: 305 TSTMRYGEEV 314
                  + V
Sbjct: 549 VILWTDDQAV 558


>UniRef50_A0KXZ1 Diguanylate cyclase n=4 Tax=Shewanella RepID=A0KXZ1_SHESA
          Length = 329

 Score =  240 bits (614), Expect = 4e-62,   Method: Composition-based stats.
 Identities = 54/195 (27%), Positives = 92/195 (47%), Gaps = 11/195 (5%)

Query: 123 ICPIMVSFSVAAINSLMKQV-------ALRADFDFLTQVYSRSGLYEALKSPSLKQTQHL 175
           +  I ++  +     + + +          AD D LTQ+Y+R   +   +  + +  Q L
Sbjct: 132 LVRIEIATDITERKQMEQALIEAKSTAERLADTDELTQLYNRRAFFNLGRQIAQQTAQPL 191

Query: 176 TVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNP 235
             ++ DID+FK IND +GH  GD  L   AR  Q  +    ++AR+GGEEF + +P+ + 
Sbjct: 192 AFIMFDIDHFKRINDRWGHAMGDAALIHIARLTQTKLRTNDILARLGGEEFGLILPNTHH 251

Query: 236 VDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDD----FNKLMVEAD 291
                +AE IR G + QP      +++ T S G+ S     +   D+       L   AD
Sbjct: 252 EQAWQVAESIRHGFDTQPLQLNGHSIHCTASFGISSLVLPQINHPDEAQTLLETLFNNAD 311

Query: 292 TCLYRSKKDGRNRTS 306
             + ++K+ GRN+  
Sbjct: 312 QAMMQAKRAGRNQVC 326


>UniRef50_C5T1B3 Diguanylate cyclase n=1 Tax=Acidovorax delafieldii 2AN
           RepID=C5T1B3_ACIDE
          Length = 445

 Score =  240 bits (614), Expect = 4e-62,   Method: Composition-based stats.
 Identities = 66/275 (24%), Positives = 122/275 (44%), Gaps = 9/275 (3%)

Query: 40  AIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVID 99
            I   ++ + + V     +            VRY   V   L  V   V  +L       
Sbjct: 166 GIRFALAGLVAGVYFLLTAHTLARGGFHNVPVRYLFAVVSGLHGVFLLVRPLLFRLVAPG 225

Query: 100 ISVGSPFSIPQMFSARLGI-ATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRS 158
               +   +  + S  + + AT+++  +     +     + +++   A+ D LT V++R 
Sbjct: 226 TVEDADAGMVALLSQFVVLEATLSLVLMAFGALMLTNEHITRELRHLAEVDPLTNVFNRR 285

Query: 159 GLYEALKS---PSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDK 215
                L+     + +    L V+++D+D+FK IND +GH+ GD+VL  F       +  +
Sbjct: 286 AFLTLLEKAISNAQRTQSGLPVLVIDLDHFKKINDTWGHQSGDEVLRHFVALANGCLRKE 345

Query: 216 GLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRAS 275
            ++ R+GGEEFA+ +P+ +      +AE++R  V   P    +  + LTVSIGV      
Sbjct: 346 DVMGRLGGEEFAIFLPNASSEGSQAVAERLRALVAHHPAMTGRGPIALTVSIGVTQYGG- 404

Query: 276 YLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRY 310
                +  + ++  AD  +YR+K+ GRNR  T+  
Sbjct: 405 ----GETSDFVLQRADEAMYRAKERGRNRVETLSP 435


>UniRef50_B1XII1 PleD protein n=3 Tax=Bacteria RepID=B1XII1_SYNP2
          Length = 516

 Score =  240 bits (613), Expect = 5e-62,   Method: Composition-based stats.
 Identities = 81/347 (23%), Positives = 141/347 (40%), Gaps = 43/347 (12%)

Query: 5   WFSEQFSTGVLIVPCMLTL--AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFP 62
           W+       ++  P +L         +P    E M+  +A+ +SV  S+ I         
Sbjct: 169 WWLASTLAHLIFTPVILLGKDFFSRKIPYHVIE-MLLILAVFISVSWSIFIQSYPVAYLL 227

Query: 63  LPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSP---FSIPQMFSARLGIA 119
           L  L W   RY   V+ LL  +   + I   A+ +    + S        Q F     ++
Sbjct: 228 LLILNWTVFRYGAFVSSLLVSIVSILAIYTTAHGLGVFVLESQNQSLLFLQSFMGVFALS 287

Query: 120 TMAICPIM---------------------------VSFSVAAINSLMKQVALRADFDFLT 152
           ++ +  ++                           +  S A +    +++      D LT
Sbjct: 288 SLLLSAVVEERSRAQTSLKKALDNSTKLILERTKELRRSEALLRQTNQELQKLVHLDGLT 347

Query: 153 QVYSRSGLYEALKSPSLK---QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQ 209
           Q+ +R    + L +   +   + + L ++L D+DYFK  ND+YGH+ GD+ L   A+ ++
Sbjct: 348 QIANRRCFNQRLTAEWHRLYREQKPLALILFDVDYFKRYNDSYGHQQGDECLIQIAQAVK 407

Query: 210 KIV-GDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY---LTV 265
            ++     LVAR GGEEF V +P+       ++A++IR+ V           +    +TV
Sbjct: 408 HLLKRPADLVARYGGEEFVVVLPNTTQEGATIVAKRIRRTVLELQIAHNATEINEAIVTV 467

Query: 266 SIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGE 312
           S+GV SG          F   + +AD  LY +K+ GRNR       E
Sbjct: 468 SLGVVSGIPQSQEKPLTF---VKKADQALYLAKQQGRNRIVVAGESE 511


>UniRef50_Q2SUR3 GGDEF domain protein n=54 Tax=Burkholderiaceae RepID=Q2SUR3_BURTA
          Length = 628

 Score =  240 bits (613), Expect = 5e-62,   Method: Composition-based stats.
 Identities = 70/315 (22%), Positives = 131/315 (41%), Gaps = 17/315 (5%)

Query: 4   DWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIV--SVIASVVIGGAGSLAF 61
            W +      V +     +  I G L    + +    I  +V  +++ +  I     L +
Sbjct: 319 PWIAGFVLVCVAVAAIAYS-PIAGHLWTRASMEGGAMIVSLVNVALLLARRIRTPLMLVY 377

Query: 62  PLPALIWCAVRYTPQV------TCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSAR 115
            +  + +        +         L     A    +++  V+  ++ +  S   ++S +
Sbjct: 378 GISVMSFALSSIAFILGKPWNHMWWLAHAIFAAGFFMLSFGVVQ-ALITTRSFATVYSQQ 436

Query: 116 LGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ-- 173
             +A +A        ++  +    +++   A  D LT   +R    E +++   +  +  
Sbjct: 437 DLMARLAESMARTEGALQELKRTNQKLEHLATTDPLTGASNRRKFIEQMQAEIARAKRDG 496

Query: 174 -HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPS 232
              +++ LD+D FK+INDNYGH+ GD VL  F R     +     +AR+GGEEF V +P 
Sbjct: 497 TAFSLLALDLDNFKTINDNYGHQVGDVVLRNFVRQCLAAIRPYDHIARVGGEEFMVLLPR 556

Query: 233 VNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADT 292
           +       +AE++R  +    F        +TVSIGV           D  ++++  AD 
Sbjct: 557 MLADTASGIAERVRTTIANASFGIDGTHTPVTVSIGVSQYG----RDGDTVDEILSAADK 612

Query: 293 CLYRSKKDGRNRTST 307
            LYR+K +GRNR   
Sbjct: 613 LLYRAKNEGRNRVVA 627


>UniRef50_A4CE22 Response regulator containing a CheY-like receiver domain and a
           GGDEF domain n=1 Tax=Pseudoalteromonas tunicata D2
           RepID=A4CE22_9GAMM
          Length = 357

 Score =  240 bits (613), Expect = 5e-62,   Method: Composition-based stats.
 Identities = 78/312 (25%), Positives = 141/312 (45%), Gaps = 20/312 (6%)

Query: 8   EQFSTGVLIVPCMLTLA---IPGVLPRFKAEQMMPAIALIVSVIASVVIGG----AGSLA 60
           +   T +L+   ++ L+   I    P F     +  + ++  ++  V  GG    A    
Sbjct: 50  DSLLTCILLASSLVVLSNAVISHFHPYFGVSCYITGLGVVGLILGLVFTGGHQNTALYWL 109

Query: 61  FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT 120
           +P P + +    Y   +   L   +  + ++   + ++     +      + S  + I  
Sbjct: 110 YPFPLVYFILFDYRKGLVANLLIFSAILFLLYQPDWILAEYQPAE-KSRFIASYLVTIFL 168

Query: 121 MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTV 177
             +       S   ++S+  Q   +A+ D LTQ+ +R  L       + ++ +    + V
Sbjct: 169 SFVAEYFRFHSHQELSSINYQRQKQANTDPLTQLPNRRFLDSVFFIGADREPKHYFPMVV 228

Query: 178 MLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVD 237
           ++ DID+FK +ND YGH+ GD VL   A  ++  +    +VAR+GGEEF + +P    VD
Sbjct: 229 VMADIDFFKRVNDTYGHDTGDHVLKHVASLLKSSLRGFDVVARIGGEEFLILLPQTMLVD 288

Query: 238 GLLMAEKIRKGVELQPF----TWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTC 293
           G+ +AEKIR   +  PF      QQ  + LTVS GV    +      +  N  ++ AD+ 
Sbjct: 289 GISVAEKIRIECQNTPFNQFDNLQQVYIDLTVSFGVAEASS-----AEQLNNAIMAADSK 343

Query: 294 LYRSKKDGRNRT 305
           LY +K+ GRN+ 
Sbjct: 344 LYLAKEQGRNQV 355


>UniRef50_D1U463 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfovibrio
           aespoeensis Aspo-2 RepID=D1U463_9DELT
          Length = 974

 Score =  240 bits (613), Expect = 5e-62,   Method: Composition-based stats.
 Identities = 55/187 (29%), Positives = 93/187 (49%), Gaps = 7/187 (3%)

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVMLL 180
               V   +     L +++   A  D LT   +R   +   E     +++    L V++L
Sbjct: 791 LLYSVIHDITERVRLEREMKRLATTDSLTGAANRHEFFRLAELELRRAMRYGHSLAVLML 850

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           DIDYFKSIND +GH+ GD VL   +  ++  + D  +  R+GGEEFA  +P  +   G+L
Sbjct: 851 DIDYFKSINDTHGHQTGDAVLKALSALVRTTLRDTDIFGRLGGEEFAAVLPETDLAGGVL 910

Query: 241 MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD 300
           +A+++R+ +       +   +  TVSIG+   R S        +  +  AD  +Y++K+ 
Sbjct: 911 VADRLRRELGALKVRLRDIEVMFTVSIGLTETRKSERL----IDDAINRADEAMYKAKRM 966

Query: 301 GRNRTST 307
           GRNR  +
Sbjct: 967 GRNRVES 973


>UniRef50_A8DJI0 Sensor protein n=1 Tax=Candidatus Chloracidobacterium thermophilum
           RepID=A8DJI0_9BACT
          Length = 750

 Score =  240 bits (613), Expect = 5e-62,   Method: Composition-based stats.
 Identities = 73/293 (24%), Positives = 123/293 (41%), Gaps = 23/293 (7%)

Query: 24  AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF 83
                   F+A   +P + LI + +         +  + L  LI            +LT 
Sbjct: 452 PATLYATHFEASLRLPDVVLIDADL-------PMADEYELCRLIKRNEATRHLPVLVLTP 504

Query: 84  VTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVA 143
                E +          + +P +  ++              I       A+        
Sbjct: 505 SPETTEKLRGLEVGATDVLTTPINPKELV-------VRVKALIAQKREFEAMLRAYHSAR 557

Query: 144 LRADFDFLTQVYSRSGLYEALKSPSL---KQTQHLTVMLLDIDYFKSINDNYGHECGDKV 200
            RA  D LT +++ +   E L   +    +  + L+V++LD+D FK  ND  GHE G+++
Sbjct: 558 HRAITDGLTGLFNHAYFLEKLTREAELAGRSGRPLSVIMLDVDRFKHFNDTNGHETGNEL 617

Query: 201 LSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKT 260
           L   AR +++      L+AR GGEEF V +P+       ++AE++R+ V   PF  ++  
Sbjct: 618 LKDLARLMERCFRRSDLLARYGGEEFVVLLPNTPKSQAAVLAERLRRRVAEYPFVGRESQ 677

Query: 261 L--YLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYG 311
               LTVS+GV +      T T D  +L+  AD  LYR+K++GRNR   +   
Sbjct: 678 PGGCLTVSLGVAAM----PTDTSDPKQLLELADRALYRAKQNGRNRVCVVESE 726


>UniRef50_C6P6Y5 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Sideroxydans
           lithotrophicus ES-1 RepID=C6P6Y5_9PROT
          Length = 671

 Score =  240 bits (613), Expect = 5e-62,   Method: Composition-based stats.
 Identities = 60/207 (28%), Positives = 96/207 (46%), Gaps = 9/207 (4%)

Query: 108 IPQMFSARLGIATMAICPIMVSF-SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKS 166
           +P   S    I       I+V+F  +       +++  RA  D LT + +R   YE  + 
Sbjct: 469 LPISVSVSAIIREQQAAGIVVAFHDITERKKFEQELERRAQIDALTSLNNRRHFYELAEQ 528

Query: 167 PS---LKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGG 223
                 +  + L +M+LD+D+FK IND YGH  GD VL        + + +  ++ R+GG
Sbjct: 529 EILRTKRYGKPLALMMLDVDHFKDINDTYGHHVGDTVLQTLGAVCLQTMREIDIIGRLGG 588

Query: 224 EEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ-QKTLYLTVSIGVGSGRASYLTLTDD 282
           EEFA+ +P          AE++R  V       +  +TL  T+SIGV    A       D
Sbjct: 589 EEFAILLPEATAAQAFDAAERLRLAVAAIAMPLEQGQTLSFTISIGVTGLVA----KDSD 644

Query: 283 FNKLMVEADTCLYRSKKDGRNRTSTMR 309
              ++  AD  +Y++K+ GRNR  +  
Sbjct: 645 IADMLKRADEAMYQAKRSGRNRVCSQE 671


>UniRef50_Q2RNX7 Putative diguanylate cyclase (GGDEF domain) with PAS/PAC sensor
           domain n=1 Tax=Rhodospirillum rubrum ATCC 11170
           RepID=Q2RNX7_RHORT
          Length = 492

 Score =  240 bits (613), Expect = 5e-62,   Method: Composition-based stats.
 Identities = 55/193 (28%), Positives = 89/193 (46%), Gaps = 7/193 (3%)

Query: 119 ATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHL 175
           A  A+  + V   +     + + +   A  D LT   +R    EA +     + +  + +
Sbjct: 304 AGQAVGLVAVITDITEQKRMEEALRRLATTDPLTGALNRRAFMEAARRDLALAQRHGEPV 363

Query: 176 TVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNP 235
           TV L DID+FK +ND +GH  GD+ L  F   +   +    ++ RMGGEEFA+ +P    
Sbjct: 364 TVALADIDHFKRVNDQHGHATGDEALKTFVATVHGALRASDVLGRMGGEEFALILPHTAL 423

Query: 236 VDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLY 295
              +L+A+++R+ +           +  TVSIG+        T     + L+  AD  LY
Sbjct: 424 ASAMLLADRLRQTLANLRVPCPSGEVEFTVSIGLAELG----THGTTIDTLLQAADEALY 479

Query: 296 RSKKDGRNRTSTM 308
           R+K  GRNR    
Sbjct: 480 RAKSAGRNRVIAA 492


>UniRef50_A1RG31 Diguanylate cyclase n=3 Tax=Shewanella RepID=A1RG31_SHESW
          Length = 362

 Score =  240 bits (613), Expect = 6e-62,   Method: Composition-based stats.
 Identities = 70/293 (23%), Positives = 134/293 (45%), Gaps = 17/293 (5%)

Query: 26  PGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALI--WCAVRYTPQVTCLLTF 83
           P  LP       +   +  +S +  +++G      + L A I    A  + P    L+  
Sbjct: 78  PKQLPPIIQWSWVVVFSQSLSSV--LILGADAGFQYYLLATIPPSFASIFKPLFYKLIQA 135

Query: 84  VTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAIN---SLMK 140
           +   +   L+ +              +M S    I  +  C ++   S A      S + 
Sbjct: 136 LI-IIVFFLICDIWFIDYEPYYLYSDEMISLFRHINVLGACALLAGVSYAYSQIVMSAIT 194

Query: 141 QVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGHECG 197
            +   A+ D LT + +R  L   +   + +  +    ++++L DIDYFK IND+YGH  G
Sbjct: 195 ALRNVANTDELTGLINRRSLTALIDREAARTLRTHASMSLVLCDIDYFKRINDSYGHAAG 254

Query: 198 DKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQ 257
           D VL   A  +Q ++ +  +VAR GGEEF + +P+ + ++ + +AE++R+ V     +++
Sbjct: 255 DHVLVNVANLLQGVLREYDVVARWGGEEFLLLLPNTDIIEAMKVAERLREIVACSHLSFE 314

Query: 258 QKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRY 310
           ++T+ +T+++GV           ++++  +  AD  LYR K+ GRN       
Sbjct: 315 EQTIPVTMTLGVAVL------GDENWHSTLARADEALYRGKRQGRNCVVQASA 361


>UniRef50_Q1D095 Response regulator/GGDEF domain protein n=3 Tax=Cystobacterineae
           RepID=Q1D095_MYXXD
          Length = 347

 Score =  240 bits (612), Expect = 6e-62,   Method: Composition-based stats.
 Identities = 63/248 (25%), Positives = 105/248 (42%), Gaps = 19/248 (7%)

Query: 73  YTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSV 132
           +      L+T    A   V       D  +  PF + ++ +    +  +      +    
Sbjct: 99  FGFIPVILMTARQAA-GKVEGLELGADDYLVKPFDMLELSARVKSMLRLKALQDALVEKN 157

Query: 133 AAINSLMKQV-----ALRA--DFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDI 182
             ++   K++      L A    D LT + +R    E L     +  +    L++++LDI
Sbjct: 158 RELDRANKELAARREELLALTRTDALTGLSNRRAFEERLNDEFARSRRYGAPLSLVMLDI 217

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           D+FK IND++GH  GD VL   A+  +  + +  L+AR GGEEF   +P   P D L + 
Sbjct: 218 DHFKRINDSFGHPFGDHVLKAVAQTARARLREVDLLARYGGEEFIALLPETGPADALRVC 277

Query: 243 EKIRKGVELQPFTWQQKT-----LYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRS 297
           E++R  +          +     + LT S+GV +  +  L        L+  AD  LY +
Sbjct: 278 ERVRDAIAALELEHVGGSGKPQCVRLTASLGVATVPSGDLP---SAEALLRAADASLYAA 334

Query: 298 KKDGRNRT 305
           K  GRNR 
Sbjct: 335 KGAGRNRV 342


>UniRef50_A1SRM4 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Psychromonas
            ingrahamii 37 RepID=A1SRM4_PSYIN
          Length = 1078

 Score =  240 bits (612), Expect = 6e-62,   Method: Composition-based stats.
 Identities = 56/200 (28%), Positives = 93/200 (46%), Gaps = 11/200 (5%)

Query: 112  FSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQ 171
             S+   I       +     V     + +++ L A  D LT + +R      L S   + 
Sbjct: 887  ISSAAIILDGRTIMVGFFHDVTERKKVEEEIKLLATTDSLTGIANRRAFSTHLASELERS 946

Query: 172  TQ---HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAV 228
             +    L++++ DIDYFK +NDN+GH+ GD VL   +  +++ +    +VAR GGEEF +
Sbjct: 947  NRYGTPLSLVMFDIDYFKKVNDNFGHDAGDDVLQALSELVKRNIRAVDIVARWGGEEFML 1006

Query: 229  AVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMV 288
             +P  +        EK+R+ +   PF    +   LTVS G+         L +D    + 
Sbjct: 1007 LMPESDISAATAAIEKLRREISDFPF---GQVGSLTVSFGITVF-----VLNEDSKVFLK 1058

Query: 289  EADTCLYRSKKDGRNRTSTM 308
              D  LY++K+ GRNR   +
Sbjct: 1059 RVDDALYQAKEKGRNRVEIL 1078


>UniRef50_C4KD29 Response regulator receiver modulated diguanylate cyclase n=2
           Tax=Betaproteobacteria RepID=C4KD29_THASP
          Length = 634

 Score =  240 bits (612), Expect = 7e-62,   Method: Composition-based stats.
 Identities = 69/267 (25%), Positives = 111/267 (41%), Gaps = 14/267 (5%)

Query: 56  AGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSAR 115
            G     L   +            +LT      E+     + +D  +  P ++  + +  
Sbjct: 367 PGMDGLDLARALRATEWGQTMYLIMLTGHENEDEVSEAFEAGVDDFLVKPVNVRTLRARL 426

Query: 116 LGIATMAICPIMVSFSVAAINSL-------MKQVALRADFDFLTQVYSRSGLYEALKSPS 168
                            A +           +++A  A  D LT + +R     AL    
Sbjct: 427 RAARHYVQLLEAWERDRAQLKQFAAELAISNRRLAHAAMTDLLTNLPNRRSGMNALAKAW 486

Query: 169 L---KQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEE 225
               +  Q L+VM+LDID+FK IND++GH  GD VL   A+ IQ+       + RMGGEE
Sbjct: 487 AASSRFEQPLSVMMLDIDHFKRINDSHGHAVGDTVLRDVAQAIQQSARKDDSMCRMGGEE 546

Query: 226 FAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNK 285
           F V  P+ +    +  AE++R+ VE       +  +  +VSIGV +            + 
Sbjct: 547 FLVICPNTDLKAAVQAAERLRRMVERLRIQAGETEIQTSVSIGVATREVGMTET----DA 602

Query: 286 LMVEADTCLYRSKKDGRNRTSTMRYGE 312
           L+  AD  LYR+K+ GRNR+  +  G+
Sbjct: 603 LVNAADRALYRAKQAGRNRSCVVVQGQ 629


>UniRef50_B1J820 Diguanylate cyclase n=1 Tax=Pseudomonas putida W619
           RepID=B1J820_PSEPW
          Length = 532

 Score =  240 bits (612), Expect = 7e-62,   Method: Composition-based stats.
 Identities = 73/285 (25%), Positives = 120/285 (42%), Gaps = 13/285 (4%)

Query: 29  LPRFKAEQMMPAIALIVSVIASVVIGGAGSLAF-PLPALIWCAVRYTPQVTCLLTFVTGA 87
           +P +    M+   A +     +VV+     LA  PL  +    + Y   V+ +   +   
Sbjct: 243 VPNYIGVPMLAGFAPVPEAHWAVVVQTPRDLALAPLGEMTRKVLLYILPVSIIGLLLMLW 302

Query: 88  VEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQ----VA 143
           +   L           S  S  Q       I    +    +  ++     L+++    + 
Sbjct: 303 MTYRLTLPLRQLAHSASHLSATQTGEQLRRIDAWYVEVAAIRRALLTGEQLLQEKFGKLR 362

Query: 144 LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV 203
            +A  D LT + +R  +  AL +     ++   V+ LDID+FK +ND +GH+ GD+VL  
Sbjct: 363 QQAQSDALTGLANRRAMQLALDALMQ-SSRAFAVLALDIDHFKRVNDTFGHDAGDEVLKH 421

Query: 204 FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL 263
            A  ++       L  R+GGEEF + +P     D   +AE+IR  VE        K   L
Sbjct: 422 LAELLRHNSRQDDLPCRVGGEEFTMLLPDTGLADARRIAERIRSAVEQADSPHVGK---L 478

Query: 264 TVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTM 308
           TVSIGV   R            ++ +AD  LY++K +GRNR   +
Sbjct: 479 TVSIGVACRRPDTQQAG----SVLKQADEQLYKAKHNGRNRVEVL 519


>UniRef50_Q31M78 Diguanylate cyclase (GGDEF domain) with PAS/PAC sensor n=3
            Tax=Synechococcus elongatus RepID=Q31M78_SYNE7
          Length = 1037

 Score =  240 bits (612), Expect = 7e-62,   Method: Composition-based stats.
 Identities = 51/199 (25%), Positives = 102/199 (51%), Gaps = 9/199 (4%)

Query: 122  AICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLK-----QTQHLT 176
             I  + +S  +     L +++  +A  D LT + +R       ++   +     +   L+
Sbjct: 841  IIGLLGISTDITEQKKLEQKLQQQATTDALTGILNRRQFITLAQAELNRIYRIQRDTSLS 900

Query: 177  VMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPV 236
            ++++DID+FK+IND+YGH  GD+VL ++    Q+ + +  + AR+GG+EF + +P  N  
Sbjct: 901  LVIIDIDHFKTINDSYGHTVGDQVLILWTNICQQNIREVDIFARLGGDEFVLMLPETNGK 960

Query: 237  DGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYR 296
                + ++IR+ V  Q     Q+ + +T+S+G+       L      ++ +  AD  LY+
Sbjct: 961  QAYQVMDRIRQLVIQQSLHLPQQAIAITISVGIAVWTPEIL----TLDQFLERADRALYQ 1016

Query: 297  SKKDGRNRTSTMRYGEEVV 315
            +K+ GR+R   +    E +
Sbjct: 1017 AKQQGRDRIILLDTSSEEI 1035


>UniRef50_B8KV43 Sensory box histidine kinase n=1 Tax=gamma proteobacterium NOR51-B
           RepID=B8KV43_9GAMM
          Length = 494

 Score =  240 bits (612), Expect = 7e-62,   Method: Composition-based stats.
 Identities = 61/196 (31%), Positives = 99/196 (50%), Gaps = 7/196 (3%)

Query: 118 IATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---H 174
           I+      IM    ++   ++ +++   AD D LT   +R  L   +KS   +  +    
Sbjct: 296 ISGQFAGSIMFLKDISDRKAVERRLKAIADKDPLTGAGNRRALESVIKSELSRAHRHDEP 355

Query: 175 LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVN 234
           L+V +LDID+FKS+NDNYGH  GD+VL   A+  + ++      AR+GGEEFA+ +P  +
Sbjct: 356 LSVAILDIDWFKSVNDNYGHLMGDRVLIDIAKLCKDLIRPYDTFARIGGEEFALLLPKTS 415

Query: 235 PVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCL 294
             +   +AE++R+ V        +  + +T+SIGV               +++  AD  L
Sbjct: 416 VPEAERLAERLRQRVAEHTTQAGENRVQVTISIGVALLAKG----AKTLEEMIESADRAL 471

Query: 295 YRSKKDGRNRTSTMRY 310
           Y +K DGRNR  T   
Sbjct: 472 YCAKLDGRNRVVTFEQ 487


>UniRef50_B4VMP7 GGDEF domain protein n=1 Tax=Microcoleus chthonoplastes PCC 7420
           RepID=B4VMP7_9CYAN
          Length = 505

 Score =  240 bits (612), Expect = 7e-62,   Method: Composition-based stats.
 Identities = 68/233 (29%), Positives = 106/233 (45%), Gaps = 15/233 (6%)

Query: 81  LTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMK 140
           + F    + I++        S        Q+ +A+LG     I          A+    +
Sbjct: 268 ILFRDRVLAILVFFKQARSESEPRLIDFIQLIAAQLGTLMQRIKVE------TALFEANQ 321

Query: 141 QVALRADFDFLTQVYSRSGLYEALKSPSLK---QTQHLTVMLLDIDYFKSINDNYGHECG 197
           ++      D LT + +R    + +     +   +   L+++L DID+FK  ND YGH+ G
Sbjct: 322 KLKYLVTIDGLTGIANRRKFDQYIHREWQRLFREQLPLSLILGDIDFFKRYNDTYGHQAG 381

Query: 198 DKVLSVFARHIQKIV-GDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTW 256
           D  L   A  I+ +V     LVAR GGEEFAV +P+ N    + +AE IR+GVE      
Sbjct: 382 DDCLRNVATKIRLLVKRPADLVARYGGEEFAVILPNTNAKGAIHVAETIRQGVETLKIPH 441

Query: 257 QQKTLY--LTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
                   +T+S+GV S   + L    +   L+ +AD  LYR+K  GRN+T  
Sbjct: 442 GGSESSKYVTLSLGVSSLIPNSLV---NVEGLINQADQALYRAKAGGRNQTVA 491


>UniRef50_A4TZM8 GGDEF domain n=1 Tax=Magnetospirillum gryphiswaldense
           RepID=A4TZM8_9PROT
          Length = 578

 Score =  240 bits (612), Expect = 7e-62,   Method: Composition-based stats.
 Identities = 62/209 (29%), Positives = 97/209 (46%), Gaps = 8/209 (3%)

Query: 103 GSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYE 162
           G       + SA L      +  I V   ++   ++ +++   A  D LT  ++R     
Sbjct: 368 GGRLDTMVLKSAYLDDEGRPVGVIGVLTDISDRKAMERELRRLATTDSLTGAFNRRHFLA 427

Query: 163 ALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVA 219
           A  +   +  +    LT+++LD+DYFKSIND +GH  GD  L      ++  + D  ++ 
Sbjct: 428 AAGTELERANRYGNPLTLLMLDVDYFKSINDAHGHGTGDDALRRLVEGLRHALRDIDVIG 487

Query: 220 RMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTW-QQKTLYLTVSIGVGSGRASYLT 278
           R+GGEEFAV +P       L+ AE++R  V            L  TVSIG+ + RA    
Sbjct: 488 RLGGEEFAVLLPETGMAGALITAERLRAQVADLRLDLPDGGQLAFTVSIGIAAPRAE--- 544

Query: 279 LTDDFNKLMVEADTCLYRSKKDGRNRTST 307
                  ++  AD  LYR+K +GRNR   
Sbjct: 545 -DGSVEAVLARADKALYRAKDEGRNRVCA 572


>UniRef50_A6G7C6 FHA domain/GGDEF domain protein n=1 Tax=Plesiocystis pacifica SIR-1
           RepID=A6G7C6_9DELT
          Length = 297

 Score =  239 bits (611), Expect = 8e-62,   Method: Composition-based stats.
 Identities = 56/173 (32%), Positives = 89/173 (51%), Gaps = 7/173 (4%)

Query: 137 SLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYG 193
           S  +++   +  D LTQV++R    E L+     + +  + L +++ DID+FK  ND YG
Sbjct: 126 SYHEEIFRLSTVDGLTQVFNRRYFMETLERELSRARRYDRPLALLIFDIDHFKRCNDTYG 185

Query: 194 HECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP 253
           H  GD VL   A  +        +V+R GGEEF V +P ++       AEKIRK +  + 
Sbjct: 186 HRAGDFVLRRIAELVTMRARKVDVVSRYGGEEFTVILPEIDIRGASAFAEKIRKLIADET 245

Query: 254 FTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
           F ++ + + +T+SIGV     S      + + ++  AD  LY +K  GRNR  
Sbjct: 246 FIFEGRKIPVTISIGVAEIGPSVA----NADDMIQTADRRLYAAKTGGRNRVV 294


>UniRef50_B7IH39 Diguanylate cyclase n=2 Tax=Bacteria RepID=B7IH39_THEAB
          Length = 167

 Score =  239 bits (611), Expect = 9e-62,   Method: Composition-based stats.
 Identities = 54/173 (31%), Positives = 92/173 (53%), Gaps = 11/173 (6%)

Query: 137 SLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNYG 193
            L K++   ++ D LT +Y+R  + E ++       +  +  +++++DID FK IND YG
Sbjct: 2   ELNKKLKYLSERDQLTDLYNRHKMNEEIRKHYYNFKRYGRPFSLLMVDIDKFKKINDTYG 61

Query: 194 HECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP 253
           H  GD+VL   A+ + K +    + +R  GEEF + +   +    + +AEKIRK +E + 
Sbjct: 62  HMVGDEVLKKLAKILVKNIRKTDIASRWVGEEFLILLSETDLEQAIEVAEKIRKTIEKES 121

Query: 254 FTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
           F    K + +TVSIGV       +   +    L++  D  LY++K+ GRNR  
Sbjct: 122 FP---KDIRITVSIGV-----DSVENHEHIKDLLILVDEKLYKAKESGRNRVE 166


>UniRef50_A9B3D1 Diguanylate cyclase n=2 Tax=Bacteria RepID=A9B3D1_HERA2
          Length = 1774

 Score =  239 bits (611), Expect = 9e-62,   Method: Composition-based stats.
 Identities = 60/193 (31%), Positives = 92/193 (47%), Gaps = 7/193 (3%)

Query: 119  ATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSL---KQTQHL 175
            A + +     +    A   L  QV   A  D LTQV +R   +E  +   +        L
Sbjct: 1586 AELGMVFASQAAIAIANAQLFGQVQRLAITDSLTQVSNRRHFFELAERQWILTCSSDHPL 1645

Query: 176  TVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNP 235
            + M+LD+D+FK +ND+YGH  GD VL   A   +  +    L+ R GGEEFA+ +P  + 
Sbjct: 1646 SAMMLDVDHFKRVNDSYGHSVGDLVLRTVADLCRANLRPSDLLGRYGGEEFAILLPDTDV 1705

Query: 236  VDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLY 295
               L +AE++R  +       +Q ++ LTVSIGV           +    L+  AD  LY
Sbjct: 1706 SAALTIAERLRVAIANHVINHEQASINLTVSIGVTGLS----KDDNSVASLLDRADRGLY 1761

Query: 296  RSKKDGRNRTSTM 308
             +K+ GR+R +  
Sbjct: 1762 IAKETGRDRVTMA 1774


>UniRef50_A1VD57 Diguanylate cyclase n=3 Tax=Desulfovibrio vulgaris
           RepID=A1VD57_DESVV
          Length = 487

 Score =  239 bits (611), Expect = 9e-62,   Method: Composition-based stats.
 Identities = 58/175 (33%), Positives = 92/175 (52%), Gaps = 6/175 (3%)

Query: 139 MKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDYFKSINDNYGHE 195
            +++ L+AD D LTQ+++R      L     +  +    +T+++LDID+FK++ND YGH 
Sbjct: 306 YREIKLQADHDALTQLHNRRSFDHRLAEEVDRHQRYGMPMTLLMLDIDHFKAVNDTYGHP 365

Query: 196 CGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFT 255
            GD VL   A+ ++         AR GGEEF V +P  +   G + AE++RK +      
Sbjct: 366 AGDAVLREVAQTMRNACRTTDFAARYGGEEFCVILPHTDGKCGRIFAERLRKRLASSRVE 425

Query: 256 WQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRY 310
              KT+ +TVSIG+ +  A+         +L+ EAD  LY +K  GRN     + 
Sbjct: 426 VDGKTIAVTVSIGLATLSAAAPL---SPERLVCEADGALYAAKAAGRNIVCEAQE 477


>UniRef50_C6WY37 Diguanylate cyclase n=1 Tax=Methylotenera mobilis JLW8
           RepID=C6WY37_METML
          Length = 395

 Score =  239 bits (611), Expect = 9e-62,   Method: Composition-based stats.
 Identities = 80/304 (26%), Positives = 135/304 (44%), Gaps = 11/304 (3%)

Query: 10  FSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWC 69
              G+LI+   +T+           +  M AI   + +  S+    A +L   + A    
Sbjct: 93  IPWGILILFVAMTICQGIWFSVINPDTRMRAIVNSL-LFFSIYTVCARALLVKIEASQKL 151

Query: 70  AVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVS 129
           A  +T      L  +     ++++ +   ++ +    SI  +      +A++    +   
Sbjct: 152 AYWFTGASFAALALLMLTRAVLMLLSPDAEVGLHVNTSINTL---PFVVASLLEFSVAFG 208

Query: 130 FSVAAINSLMKQVALRADFDFLTQVYSRSGLYE---ALKSPSLKQTQHLTVMLLDIDYFK 186
             +   + L+  V   A  D LT   +R  + E    L++  ++  + L +M++DID+FK
Sbjct: 209 LLLMLNHRLIADVYQMASRDALTGAMNRRRIEEEAVRLRARCIRTGEPLAIMMIDIDFFK 268

Query: 187 SINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIR 246
           SIND YGH  GDKVL   A   QK +  +   AR GGEEF + + S    + L +AE++R
Sbjct: 269 SINDRYGHPAGDKVLRAIADIAQKSIRAEDYFARYGGEEFCMLLTSTTESEALDLAERLR 328

Query: 247 KGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
                   T  ++ L +TVSIGV       L   D    ++  AD  LY +K++GRNR  
Sbjct: 329 LAFAEFTLTLGKEQLNITVSIGVADSSMVGLEFAD----MVTAADKALYCAKENGRNRVI 384

Query: 307 TMRY 310
           T   
Sbjct: 385 TYSS 388


>UniRef50_Q47A94 Diguanylate cyclase n=1 Tax=Dechloromonas aromatica RCB
           RepID=Q47A94_DECAR
          Length = 638

 Score =  239 bits (611), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 55/184 (29%), Positives = 90/184 (48%), Gaps = 7/184 (3%)

Query: 128 VSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLDIDY 184
           +   +  I  L   +   A  D LT +Y+R  L E L+    +  +    L++++LDID+
Sbjct: 457 LHARIEEIGRLQVALQELAVRDSLTGLYNRRYLDETLEREVSRARREGIPLSLVMLDIDH 516

Query: 185 FKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEK 244
           FK +ND YGH+ GD+VL + A  +   +  + +  R GGEEF + +P++     +L A+ 
Sbjct: 517 FKQVNDTYGHQVGDEVLRILASTLSADIRAEDVACRYGGEEFLILLPNMPLETTMLRAQG 576

Query: 245 IRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNR 304
            R  VE          +  T+S+GV +            + L   AD  LYR+K +GRN+
Sbjct: 577 WRSAVEALSVKHGNFQITFTISLGVAAY----PEHGKTPDDLTRCADQALYRAKNEGRNQ 632

Query: 305 TSTM 308
            S  
Sbjct: 633 VSVF 636


>UniRef50_A0L8W1 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Magnetococcus sp.
           MC-1 RepID=A0L8W1_MAGSM
          Length = 564

 Score =  239 bits (611), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 55/195 (28%), Positives = 96/195 (49%), Gaps = 10/195 (5%)

Query: 123 ICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTVML 179
           I    +   V     L +Q+   +  D LT++ +R  + E L     +  ++   L+++L
Sbjct: 375 IGSAALILDVTDEKRLEQQLRELSTTDGLTKLINRRRMDELLDEELKRAVRYGLNLSILL 434

Query: 180 LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGL 239
           LD+D+FK  ND YGHE GD VL   A  ++    +     R GGEEF V +P+ +    +
Sbjct: 435 LDVDHFKKFNDTYGHEQGDHVLIALAAEMKSYFRNIDYPCRYGGEEFFVILPNTDADGAI 494

Query: 240 LMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKK 299
            +A+++R+ V  +        L +T+SIGV S     +T     + ++  AD+ LY +K+
Sbjct: 495 KVADRLRERVAEKEV----DGLRVTISIGVASYPDLSITR---PDAMVRAADSALYVAKE 547

Query: 300 DGRNRTSTMRYGEEV 314
            GRN+       ++ 
Sbjct: 548 QGRNKVVYASEAKQT 562


>UniRef50_B3PC25 YaiC/YhcK/ArdA family protein n=1 Tax=Cellvibrio japonicus Ueda107
           RepID=B3PC25_CELJU
          Length = 330

 Score =  239 bits (610), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 77/316 (24%), Positives = 141/316 (44%), Gaps = 20/316 (6%)

Query: 10  FSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWC 69
           F  G +       LA     P  +    +   A       +++          L  ++W 
Sbjct: 20  FLNGFVWPHIAYWLAKRSQSPFLREHLHLQLDAASGGFWVALMGFNPLGSCLIL-MMLWM 78

Query: 70  ----AVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSAR--LGIATMAI 123
               A  +   +  ++T + G +  +LV  S +            +++A   L I  +AI
Sbjct: 79  NNIAAGGFRLFLRGVVTSLAGLLMGLLVVRSFLHWEFNLSSDPVMIYAALPMLVIYPLAI 138

Query: 124 CPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEA---LKSPSLKQTQHLTVMLL 180
             I   F+   ++S  + +   +  D LT +++RS   E    L + + +  Q L ++LL
Sbjct: 139 GSITYRFA-MQLHSQKELLKHLSRTDGLTGLFNRSYWEERVLALINQTQRSGQPLCLVLL 197

Query: 181 DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL 240
           D+D+FK IND YGH  GD++L   A+ +Q  + +  L+ R GGEEFA+A+ + +    L 
Sbjct: 198 DVDHFKMINDTYGHGRGDQILQQIAQCLQVNLREHELLGRYGGEEFALALANTSLPAALA 257

Query: 241 MAEKIRKGVELQPFTWQQK----TLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYR 296
            AE++R+ V    F  + +     L  ++S+G+   +         F +    AD  LY+
Sbjct: 258 TAERLRQAVATMNFADEHEPRLAPLCCSISLGLAPWQPGI-----SFLEWQRAADQALYQ 312

Query: 297 SKKDGRNRTSTMRYGE 312
           +K++GRNR+   +  E
Sbjct: 313 AKREGRNRSCIYQPQE 328


>UniRef50_B6IN39 Response regulator With diguanylate cyclase (GGDEF) domain,
           putative n=12 Tax=Alphaproteobacteria RepID=B6IN39_RHOCS
          Length = 482

 Score =  239 bits (610), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 63/270 (23%), Positives = 107/270 (39%), Gaps = 15/270 (5%)

Query: 46  SVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSP 105
             +  + +         L + +    R       LL   T    +        +  V  P
Sbjct: 200 FELVIISLTLMREDGLRLCSQLRSHERTRQVPILLLADETDMDRVAKGLELGANDYVIKP 259

Query: 106 FSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK 165
               ++ +            +        + S  +Q    A  D LT +++R  L   L 
Sbjct: 260 IDRNELMARTR-------TQVRRKRYQDRLRSNYEQSLSLALTDSLTGLFNRRYLSAHLP 312

Query: 166 SPSLK---QTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMG 222
               +     + +  +L DID+FK +ND +GH  GD+VL   A    + + +  LV R+G
Sbjct: 313 RLLDRGGGNQKPVAALLFDIDHFKIVNDTWGHSAGDEVLREVAVRTSRNLRNFDLVTRLG 372

Query: 223 GEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQ----KTLYLTVSIGVGSGRA-SYL 277
           GEEF V +P  +    + +AE++R+ +  +PF          + +T+SIGV         
Sbjct: 373 GEEFVVVMPDTDLSSAMTVAERLRRRIADEPFKVTATAGTGEITVTISIGVAVADGTDGD 432

Query: 278 TLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
              +  + L+  ADT LYR K+ GRNR   
Sbjct: 433 GRGESGDSLLRRADTALYRVKRSGRNRVVA 462


>UniRef50_C8X290 Diguanylate cyclase with PAS/PAC sensor n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8X290_DESRD
          Length = 769

 Score =  239 bits (610), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 58/185 (31%), Positives = 88/185 (47%), Gaps = 7/185 (3%)

Query: 125 PIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLD 181
            + V   V A      ++   A  D LT V++R   +E        + +    L+++L D
Sbjct: 582 YVAVRKEVTAQKQAESKLRELATRDSLTGVWNRRYFFELAARELESAQRYKHPLSLILYD 641

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           ID+FK IND YGH  GD+VL    + +   + +  L+AR+GGEEFAV +P         +
Sbjct: 642 IDHFKRINDTYGHMIGDEVLRQLTQLVGANLRNVDLLARVGGEEFAVLLPHTYLEQAHTV 701

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
           A +I +GV       +   L LT+SIG+ S         +    L+ +AD  LY +K  G
Sbjct: 702 ARRILRGVNEAVIRTEAGPLQLTISIGMSS----SAHADNCLESLIHDADQALYAAKNKG 757

Query: 302 RNRTS 306
           RN   
Sbjct: 758 RNSIC 762


>UniRef50_A8UY29 Putative uncharacterized protein n=1 Tax=Hydrogenivirga sp.
           128-5-R1-1 RepID=A8UY29_9AQUI
          Length = 336

 Score =  239 bits (610), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 59/194 (30%), Positives = 98/194 (50%), Gaps = 8/194 (4%)

Query: 122 AICPIMVSFSVAAINSLMK-QVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTV 177
            +  +   FS      L K ++  +A  D LT +Y+R  L EA      +  +    +++
Sbjct: 146 ILRSLAFIFSFIVKEELEKKRLLEKAIIDHLTGLYNRFYLEEAGAREIARAKRYGFPISL 205

Query: 178 MLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVD 237
           ++ D+D FK +ND YGH+ GD+VL  FA  +   V    +  R GGEEF V +P   P +
Sbjct: 206 IMFDLDNFKQVNDTYGHQVGDRVLVKFASIVSSNVRSTDMPVRYGGEEFVVLLPHTYPEE 265

Query: 238 GLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRS 297
            + +AE+IR+  E   F ++ + + LTVS G+    +   +L +    L+  AD  +Y +
Sbjct: 266 AVKVAERIREEFEKFLFRFEGEVMRLTVSAGISFCNSGECSLGE----LIQMADKAMYEA 321

Query: 298 KKDGRNRTSTMRYG 311
           K+ G+NR     Y 
Sbjct: 322 KEKGKNRIEVFSYQ 335


>UniRef50_Q21GT7 GGDEF domain n=1 Tax=Saccharophagus degradans 2-40
           RepID=Q21GT7_SACD2
          Length = 346

 Score =  239 bits (610), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 74/320 (23%), Positives = 135/320 (42%), Gaps = 24/320 (7%)

Query: 10  FSTGVLIVPCMLTLAIPGVLPRFKAEQMMPA--IALIVSVIASVVIGGAGS-----LAFP 62
           F + V+I      L   G   R K   M  A  I  +V  + SV     G      L   
Sbjct: 31  FVSLVVINAVFFYLIYRGYNLRCKDHSMTAAQMIVSLVPTLYSVYFLDLGQARASFLVVA 90

Query: 63  LPALIW--CAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT 120
           +  L++   A+     +   + F+   + ++L+ N     S+     + Q F+  + +  
Sbjct: 91  IVPLLYGMLALTTRTFLQIGILFIALYILMILLINKNRPDSINPTMEVLQAFALIVVVIQ 150

Query: 121 MAICPIMVSFSVAAINSLMKQV-------ALRADFDFLTQVYSRSGLYEALKSPSLKQTQ 173
           + I    +S   + + +  K++       +  A+ D LT + +R  ++E L +   ++ +
Sbjct: 151 ITIIGGYISGLRSKLRNRNKELNIALVKISDMANRDELTGIANRRKIFEVLDTEVKRKRE 210

Query: 174 H---LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAV 230
               + + +LD+D+FK IND YGH+ GD+VL   A  + K +       R GGEEF + +
Sbjct: 211 PNTAIGICILDVDHFKRINDTYGHQAGDEVLKRIAEEVPKSLRTMDCFGRYGGEEFLLIL 270

Query: 231 PSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEA 290
           PS +     + A ++R+ V    F        +T+SIG+           ++ +  +  A
Sbjct: 271 PSTSLEGTEIKANRVREEVAKLEFKNLPPGEKVTISIGIAEYFPE-----EEIDATIQRA 325

Query: 291 DTCLYRSKKDGRNRTSTMRY 310
           D  LY +K  GRN       
Sbjct: 326 DKALYEAKAHGRNCCVVHPS 345


>UniRef50_A9FZW1 FHA domain protein n=1 Tax=Sorangium cellulosum 'So ce 56'
           RepID=A9FZW1_SORC5
          Length = 299

 Score =  239 bits (610), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 58/174 (33%), Positives = 90/174 (51%), Gaps = 7/174 (4%)

Query: 137 SLMKQVALRADFDFLTQVYSRSGLYEALKSPS---LKQTQHLTVMLLDIDYFKSINDNYG 193
              +++      D LTQ++++  LYEAL+       +  + L ++L DID+FK IND +G
Sbjct: 130 QYHEEIYRMTIIDGLTQIHNKRYLYEALEREIIRGRRHERDLAILLFDIDHFKRINDVHG 189

Query: 194 HECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQP 253
           H  GD VL   AR +Q  +    + AR GGEEFA+ +P  +      + E +R+ V    
Sbjct: 190 HLAGDFVLKEVARIVQSRIRRDEVFARYGGEEFAIILPETSIEGAAALGETLRQKVAEHL 249

Query: 254 FTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
           F +Q  ++ +T+S+GV   +    T  D    L+  AD  LY +K  GRNR   
Sbjct: 250 FVFQADSIRVTISVGVALLQEGDRTAND----LIKRADERLYHAKNSGRNRVCA 299


>UniRef50_D1U6K0 Diguanylate cyclase with PAS/PAC sensor and hemerythrin-like
           metal-binding domain n=1 Tax=Desulfovibrio aespoeensis
           Aspo-2 RepID=D1U6K0_9DELT
          Length = 457

 Score =  239 bits (610), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 54/187 (28%), Positives = 92/187 (49%), Gaps = 7/187 (3%)

Query: 125 PIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQ---HLTVMLLD 181
            I     +       +++ L +  D LT+V +R    E       +  +      ++++D
Sbjct: 126 FISQIQDITRRKQAEQELLLVSQQDPLTKVANRRFFMEHATRELTRGKRFHEPQAILIID 185

Query: 182 IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM 241
           ID+FK+IND +GH+ GD+VL   A    K + +  +  R+GGEEFA  + + N     ++
Sbjct: 186 IDHFKTINDKHGHDVGDEVLKAMATACSKALREVDVFGRIGGEEFAAMLLNTNDSVARIV 245

Query: 242 AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDG 301
           AE++R+ VE        K +  T+SIG+ S        ++  +  M  AD  LYR+K+ G
Sbjct: 246 AERVRESVERLSVNVGGKEIPFTISIGLVSFLGG----SNTLDDRMKMADKALYRAKESG 301

Query: 302 RNRTSTM 308
           RNR   +
Sbjct: 302 RNRVEVL 308


>UniRef50_Q4KKJ4 Diguanylate cyclase, putative n=5 Tax=Pseudomonas fluorescens
           RepID=Q4KKJ4_PSEF5
          Length = 727

 Score =  239 bits (610), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 56/175 (32%), Positives = 95/175 (54%), Gaps = 8/175 (4%)

Query: 136 NSLMKQVALRADFDFLTQVYSRSGLYEALKSP---SLKQTQHLTVMLLDIDYFKSINDNY 192
              +++   +A  D LT + +R+   E L+       +    L + +LD+D+FK INDNY
Sbjct: 557 REHLEEQRQKALIDPLTGLPNRAAWSERLEHEVGQWQQHGNSLLLAMLDLDHFKRINDNY 616

Query: 193 GHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQ 252
           GH  GDKVL + A  ++K +     +AR GGEEF + +P+     G+ + E +R  +E  
Sbjct: 617 GHLAGDKVLKIIANVLRKRLRGSDFIARFGGEEFVLLLPNTPWPVGVRIVEALRAAIEAC 676

Query: 253 PFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST 307
           PF ++ + + +TVS+G+ + +A   +     + ++  AD  LYR+K  GRNR   
Sbjct: 677 PFHFKGEPVTITVSVGLSAFKAGDRS-----DLVIKRADQALYRAKDAGRNRVEA 726


>UniRef50_Q1MYJ5 Response regulator containing a CheY-like receiver domain and a
           GGDEF domain n=1 Tax=Bermanella marisrubri
           RepID=Q1MYJ5_9GAMM
          Length = 642

 Score =  239 bits (610), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 74/346 (21%), Positives = 141/346 (40%), Gaps = 46/346 (13%)

Query: 10  FSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVV-------IGGAGSLAFP 62
           F   +L+    + +     +           + +I   +  +                F 
Sbjct: 295 FYWYLLLSIVFIFIPYSISIRIGAFFAWTQILLIIYITLYMLNRGHPSSRYFAVAWAVFL 354

Query: 63  LPALIWCAVRYTPQVTCL---LTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSAR---- 115
           + AL+    ++      L        GA   ++  +  +   + +         AR    
Sbjct: 355 IGALLLALNKFAFLPITLASEYGLQIGAGLEIMFLSLALADRMANTQREKISAQARSLDL 414

Query: 116 ----------LGIATMAICPIM-----------------VSFSVAAINSLMKQVALRADF 148
                     L  A M    I                  +S ++  +++  +++   +  
Sbjct: 415 AHQVTQEREKLYRAEMENLKIAREHNEVLEKTVDDRTKELSEALEELSNAHEKLKNISVT 474

Query: 149 DFLTQVYSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFA 205
           D LT++++R    +  +S   +  +H   + +++LDID+FK +NDN+GH  GD  L   A
Sbjct: 475 DALTKIHNRYFFDQHWRSEFKRAHRHKMSIALIILDIDHFKKVNDNFGHPAGDLCLQKVA 534

Query: 206 RHIQ-KIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLT 264
           + I+ +   +  LV R+GGEEFAV +P  + +    +AEKIR  +E +  +W+ KT+ +T
Sbjct: 535 QSIRIQANRESDLVCRLGGEEFAVILPGTDEMGAYEVAEKIRHTIEKRHISWEGKTIKIT 594

Query: 265 VSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRY 310
           VSIG+ +      +     N +  +AD  LY++K +GRNRT     
Sbjct: 595 VSIGISAMTPR-KSDEKMRNIMFNQADQALYQAKGNGRNRTVIFES 639


>UniRef50_C0Z6I5 Putative uncharacterized protein n=1 Tax=Brevibacillus brevis NBRC
           100599 RepID=C0Z6I5_BREBN
          Length = 530

 Score =  238 bits (609), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 57/189 (30%), Positives = 94/189 (49%), Gaps = 8/189 (4%)

Query: 123 ICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDI 182
           +    + F++  I    +Q+   A  D LT + +R  L E ++     +    ++M++D+
Sbjct: 350 LLSRAIRFALTNIKKKTEQLTHDARTDPLTGLTNRRTLEETMQKWMA-EQIPFSIMMMDL 408

Query: 183 DYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA 242
           D FK+IND YGH+ GD+VL  FA+ I   +  + +  R GGEEF V V      +   +A
Sbjct: 409 DRFKAINDTYGHQAGDEVLRHFAKIISSSLRPEDVSCRFGGEEFVVLVSHTGLEEAYQVA 468

Query: 243 EKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGR 302
           E+IR+ +E +     Q    LTVS G+      Y +       L+  AD  +Y++K+ GR
Sbjct: 469 ERIRRALETRTNPIGQ---RLTVSQGIA----HYPSHAVSPEGLLHVADEAMYKAKRAGR 521

Query: 303 NRTSTMRYG 311
           N+T      
Sbjct: 522 NQTMIAEEE 530


>UniRef50_Q6AL41 Putative uncharacterized protein n=1 Tax=Desulfotalea psychrophila
           RepID=Q6AL41_DESPS
          Length = 516

 Score =  238 bits (609), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 54/195 (27%), Positives = 98/195 (50%), Gaps = 4/195 (2%)

Query: 121 MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQH---LTV 177
           +    I +      +    +Q+   A+ D LT  Y+      AL     + +++   +++
Sbjct: 318 LVETTIELEKLTEELAKKNRQLETLANIDGLTNCYNHRYFQNALDQELSRSSRNSLAISL 377

Query: 178 MLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVD 237
           ++ DID FK  ND+YGH+ GD +L    R IQ+ +    ++AR GGEEF + +P     D
Sbjct: 378 IMFDIDNFKRFNDSYGHQAGDFILCELTRLIQEQIRKDDVLARYGGEEFVIILPETEKED 437

Query: 238 GLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRS 297
            L++AEK+R   E   F    KT  +T+S+GV +  ++ ++   +    + + D  LY +
Sbjct: 438 ALIVAEKVRHACEEHSFQNIHKTHQITISLGVATEHSAQISPL-NKTSFIDKTDLALYSA 496

Query: 298 KKDGRNRTSTMRYGE 312
           K++GRN+       +
Sbjct: 497 KENGRNKVVVYSPKK 511


>UniRef50_A3J836 Putative diguanylate cyclase (GGDEF domain) n=1 Tax=Marinobacter
           sp. ELB17 RepID=A3J836_9ALTE
          Length = 588

 Score =  238 bits (609), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 81/308 (26%), Positives = 138/308 (44%), Gaps = 16/308 (5%)

Query: 11  STGVLIVPCMLTLAIPG-VLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWC 69
           S+G+      L+       L R      +   AL V   A    G A  LAF +  L   
Sbjct: 269 SSGLAFATNFLSTKRRQPRLHRTFQTIGVAYFALFVVCFALGEQGLALRLAFLVAPLFSV 328

Query: 70  AVRYTPQVTCLLT------FVTGAVEIVLVANSVID-ISVGSPFSIPQMFSARLGIAT-M 121
            + Y    + +        F+ G +  V+ A+     ++   P++    ++  +G+    
Sbjct: 329 LMLYMGASSWVAGNQFARYFMLGTLASVVGASITASTVTGMIPYTQLGYYAVDIGMIVDA 388

Query: 122 AICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY---EALKSPSLKQTQHLTVM 178
            +  + ++  V             A  D LT + +R G     E+L S   ++ +++ V 
Sbjct: 389 ILLMLALADLVRKNEEARTAAEQNAQTDLLTGLSNRRGFLPVAESLWSLVTRKNRNVCVA 448

Query: 179 LLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDG 238
           ++DID FK+IND YGH  GDKVL V A  + +      L+AR GGEEF + +P  +  + 
Sbjct: 449 MIDIDRFKNINDQYGHAVGDKVLKVIADELYRSRRRGDLLARWGGEEFTLLLPETSEAEA 508

Query: 239 LLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSK 298
           L +AE+ R  +E      + + +  T+SIGV S  + ++      ++ +  AD  LYR+K
Sbjct: 509 LKVAERFRHNIEQLVTNDRGRVIQCTISIGVTSRHSEHV----TLDQAIARADEELYRAK 564

Query: 299 KDGRNRTS 306
             GRN+ S
Sbjct: 565 LQGRNQVS 572


>UniRef50_A8UWP4 Response regulator containing a CheY-like receiver domain and a
           GGDEF domain n=1 Tax=Hydrogenivirga sp. 128-5-R1-1
           RepID=A8UWP4_9AQUI
          Length = 425

 Score =  238 bits (609), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 75/326 (23%), Positives = 128/326 (39%), Gaps = 25/326 (7%)

Query: 10  FSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGG-------AGSLAFP 62
           F     ++   LT  I           ++  I  +  V    +I G        G +   
Sbjct: 99  FVIPFGVLFLFLTFKIQNERLIEFLHSLLVLIGGLGIVAMIYLISGDKYYLYYPGLMLVI 158

Query: 63  LPALIWCAVRYTPQVTCLLTFVTGAVEIVLVA---------NSVIDISVGSPFSIPQMFS 113
             A    A+R+      +L  +     + L            ++  ++  +   +P  + 
Sbjct: 159 FYAFTLSALRFYYATASVLALLLTYPVVDLYLLKTPEELHITNMFFLTSSALLGMPVSYL 218

Query: 114 ARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQ-- 171
                    +  ++++F     + L  ++   +  D LT V +R    +  +    +   
Sbjct: 219 LERHARKDFLLTMLLAFEKRKTDELNVRLRDISFIDGLTGVANRLRFDDFFRKEWRRARR 278

Query: 172 -TQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVG-DKGLVARMGGEEFAVA 229
             + +++++LDID+FK+ ND  GH  GD+ L   A+ IQ  +  D  LVAR GGEEF V 
Sbjct: 279 TKRPISILMLDIDFFKNYNDLLGHLEGDECLKNVAKTIQSHIRADVDLVARYGGEEFVVV 338

Query: 230 VPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY--LTVSIGVGSGRASYLTLTDDFNKLM 287
           +P  +    L +AE+IR+ +E          +   +TVSIGV S              L+
Sbjct: 339 LPETDLKGALKVAERIRRDIEGLKIAHPGSQVSKFVTVSIGVASIVPIDNLKK---EVLL 395

Query: 288 VEADTCLYRSKKDGRNRTSTMRYGEE 313
             AD  LY +KK GRNR        E
Sbjct: 396 NMADKALYVAKKRGRNRVEAYSIEME 421


>UniRef50_Q2IZF7 Diguanylate cyclase n=5 Tax=Rhodopseudomonas palustris
           RepID=Q2IZF7_RHOP2
          Length = 753

 Score =  238 bits (608), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 57/187 (30%), Positives = 91/187 (48%), Gaps = 12/187 (6%)

Query: 133 AAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPS---LKQTQHLTVMLLDIDYFKSIN 189
           + +      +A +A  D LT +++R    E L        +  Q L++++ D+D+FK +N
Sbjct: 552 SELQERAAALARQATTDPLTGLHNRLRFNEGLAQELARVRRTGQPLSLVMFDVDHFKEVN 611

Query: 190 DNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGV 249
           D YGH  GD+VL   ++     +    L+AR GGEEFA+ +   +    + +AE +R+ V
Sbjct: 612 DRYGHPTGDQVLIRLSQTAAAQLRQTDLLARWGGEEFAILLVDADLHAAVEVAENLRRLV 671

Query: 250 ELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTST-M 308
              PF    +   +T S GV   R       +  + L+  AD  LYR+K +GRNR     
Sbjct: 672 ARTPF---DQIGSVTASFGVAECRP-----DESADSLLERADAALYRAKSNGRNRVEIDA 723

Query: 309 RYGEEVV 315
              EE V
Sbjct: 724 PVIEETV 730


>UniRef50_C1F5G2 GAF domain/GGDEF domain protein n=1 Tax=Acidobacterium capsulatum
           ATCC 51196 RepID=C1F5G2_ACIC5
          Length = 369

 Score =  238 bits (608), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 69/225 (30%), Positives = 104/225 (46%), Gaps = 12/225 (5%)

Query: 93  VANSVIDISVGSPFSIP-QMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFL 151
           VA  V+   V + F +  Q+   R   A  A     +  S   +      +      D L
Sbjct: 144 VALRVLARQVAAQFQMRRQLLELREARAKQAKTEQRLRESQTRLKEANACLQEMVTTDAL 203

Query: 152 TQVYSRSGLYEALKSPSL---KQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHI 208
           T V +R    E L+       +    L+++++D+D+FK +ND  GHE GD VL + A+ +
Sbjct: 204 TGVKNRRAFDEGLQQAWKMSARTKSPLSLLMVDVDHFKRVNDTLGHEAGDDVLRLVAQTL 263

Query: 209 QKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIG 268
           Q +     +VAR GGEEF V +P       +  AE++R  +     +W+   L  TVSIG
Sbjct: 264 QFMTRSTDMVARYGGEEFVVVLPGTEAEPAVAFAEQLRLNIAN--LSWRGHPL--TVSIG 319

Query: 269 VGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEE 313
           V SG  S  T  +    L+  AD  LYR+K  GRNR       ++
Sbjct: 320 VDSGSGSGKTECE----LVAHADAALYRAKNSGRNRVLRFDPEKD 360


>UniRef50_Q2SPL3 Response regulator containing a CheY-like receiver domain and a
           GGDEF domain n=1 Tax=Hahella chejuensis KCTC 2396
           RepID=Q2SPL3_HAHCH
          Length = 373

 Score =  238 bits (608), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 61/224 (27%), Positives = 103/224 (45%), Gaps = 10/224 (4%)

Query: 97  VIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVA--AINSLMKQVALRADFDFLTQV 154
           V   S     +   M  A++ +    I  +  S  V    +N  ++++++ A  D LT +
Sbjct: 153 VTPNSEFVLLTALFMVMAQMALIGGFISKLRASLRVKNHQLNEALEKISVMASTDELTGL 212

Query: 155 YSRSGLYEALKSPSLKQTQH---LTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKI 211
            +R  L + L +   +  +    L++ LLDID+FK IND+YGH+ GD VL   A+ +Q +
Sbjct: 213 CTRRELMKQLSNEFSRCRRSSGALSLCLLDIDHFKRINDSYGHQAGDAVLKKVAQTMQSL 272

Query: 212 VGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGS 271
           V     + R GGEEF + +P        + AE++R+ V   PF        +T+S+G   
Sbjct: 273 VRSIDCLGRYGGEEFLLILPQTPLDGAFITAERLRRAVMDIPFPEVAPEFRVTISLGAAE 332

Query: 272 GRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV 315
                    +    L+   D  LY +K  GRNR  +     + +
Sbjct: 333 L-----EEGEAMETLISRVDKALYAAKGAGRNRVVSAEQTADTL 371


>UniRef50_C6CQG0 Diguanylate cyclase n=7 Tax=Enterobacteriaceae RepID=C6CQG0_DICZE
          Length = 491

 Score =  238 bits (608), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 58/239 (24%), Positives = 106/239 (44%), Gaps = 15/239 (6%)

Query: 74  TPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVA 133
              +   +    G   +V   ++  D  + S        S  + +A + +  + +     
Sbjct: 265 NIFLNTRIIPEFGWKLMVEQNSTPHDRQLWSTLLKNTGISITVSVAMLLLIWLTIG---- 320

Query: 134 AINSLMKQVALRADFDFLTQVYSRSGL---YEALKSPSLKQTQHLTVMLLDIDYFKSIND 190
              +  +++ L A  D LT + +R      +  L+     Q +  +++L+D+DYFK IND
Sbjct: 321 ---AYQRRLELMATTDKLTGLMNRQAFEYVFRTLRIKQSTQHRTFSIILIDLDYFKKIND 377

Query: 191 NYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVE 250
            YGH  GD+VL   AR IQ+ +       R GGEEF + +   +      +AEKIR+ + 
Sbjct: 378 QYGHHVGDRVLVRTARLIQRTIRKTDSACRWGGEEFVLLLADCSRSQAHFIAEKIRRAIR 437

Query: 251 LQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMR 309
               + Q + + LT+S G+           +  + L+  AD  LY++K+ GR++     
Sbjct: 438 FALVSHQHQVINLTISCGIAESHP-----GESIDHLVQRADNALYQAKRQGRDQAVIAE 491


>UniRef50_B5JS67 Gaf/pas/ggdef domain protein n=1 Tax=gamma proteobacterium HTCC5015
           RepID=B5JS67_9GAMM
          Length = 488

 Score =  238 bits (608), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 66/227 (29%), Positives = 96/227 (42%), Gaps = 12/227 (5%)

Query: 91  VLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDF 150
           V    SV  I      S     S    I         +      +     ++A  A+ D 
Sbjct: 266 VWGRLSVALIRTPDQGSPQHFVSQVQDITQQVESSKALEQRQIELEEKNIELATLANTDP 325

Query: 151 LTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARH 207
           LTQ+ +R    E L    +   +Q Q L  +LLD+D+FKS ND YGH  GD+ L      
Sbjct: 326 LTQLATRRYFMERLSTAIAYCQRQQQPLAYVLLDVDHFKSFNDQYGHLAGDEALKRVGSI 385

Query: 208 IQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSI 267
           ++    +  L +R GGEEFA+ +PS    + L +AE++R  +E            +T S+
Sbjct: 386 LKHSPREYDLASRYGGEEFALYLPSTTAQEALQVAERLRTAIEE----ISDLDRPITASL 441

Query: 268 GVGSGRASYLTLTDD-----FNKLMVEADTCLYRSKKDGRNRTSTMR 309
           GV     +     D         L+  ADT LY++K  GRNRT    
Sbjct: 442 GVALLDPASALPPDSDMKTVIEALIQRADTALYQAKSQGRNRTLLSE 488


>UniRef50_A8UY33 Putative uncharacterized protein n=1 Tax=Hydrogenivirga sp.
           128-5-R1-1 RepID=A8UY33_9AQUI
          Length = 345

 Score =  238 bits (608), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 52/179 (29%), Positives = 86/179 (48%), Gaps = 7/179 (3%)

Query: 131 SVAAINSLMKQVALRADFDFLTQVYSRSGLYEALK---SPSLKQTQHLTVMLLDIDYFKS 187
            +  +   +++V   A+ D LT + +R     AL        K     +V+++D+D FK 
Sbjct: 170 EIERLREELRRVKEEANIDPLTGLRNRRSFERALSEFFRDFKKFGYPFSVIMIDLDNFKQ 229

Query: 188 INDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRK 247
           IND YGH  GDKVL      ++  +  K + AR GGEEF + +P +   + L++AE++RK
Sbjct: 230 INDTYGHLAGDKVLKEIGNILRNYLRAKDVPARTGGEEFTIILPGITREEALMVAERLRK 289

Query: 248 GVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKDGRNRTS 306
            +       + K +  T S GV           +    L+  AD  LY++K+ G+N   
Sbjct: 290 VIANYTVEHEDKKINPTASFGVAEVNEQV----ETPEDLLRLADENLYKAKRRGKNTVV 344


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.316    0.167    0.590 

Lambda     K      H
   0.267   0.0509    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 2,163,171,870
Number of Sequences: 3077464
Number of extensions: 126825695
Number of successful extensions: 524318
Number of sequences better than 1.0e-01: 250
Number of HSP's better than  0.1 without gapping: 23243
Number of HSP's successfully gapped in prelim test: 2382
Number of HSP's that attempted gapping in prelim test: 445980
Number of HSP's gapped (non-prelim): 29335
length of query: 315
length of database: 1,040,396,356
effective HSP length: 128
effective length of query: 187
effective length of database: 646,480,964
effective search space: 120891940268
effective search space used: 120891940268
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (20.8 bits)
S2: 94 (40.5 bits)
