Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	I	P	F	T	R	W	P	E	E	F	A	R	R	Y	R	E	K	G	Y	W	Q	D	L	P	L	T	D	I	L	T	R	H	A	A	S	D	S	I	A	V	I	D	G	E	R	Q	L	S	Y	R	E	L	N	Q	A	A	D	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	A	C	S	L	R	R	Q	G	I	K	P	G	E	T	A	L	V	Q	L	G	N	V	A	E	L	Y	I	T	F	F	A	L	L	K	L	G	V	A	P	V	L	A	L	F	S	H	Q	R	S	E	L	N	A	Y	A	S	Q	I	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	A	L	L	I	A	D	R	Q	H	A	L	F	S	G	D	D	F	L	N	T	F	V	T	E	H	S	S	I	R	V	V	Q	L	L	N	D	S	G	E	H	N	L	Q	D	A	I	N	H	P	A	E	D	F	T	A	T	P	S	P
Secondary structure
SS confidence
Disorder																																																							?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	D	E	V	A	Y	F	Q	L	S	G	G	T	T	G	T	P	K	L	I	P	R	T	H	N	D	Y	Y	Y	S	V	R	R	S	V	E	I	C	Q	F	T	Q	Q	T	R	Y	L	C	A	I	P	A	A	H	N	Y	A	M	S	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		P	G	S	L	G	V	F	L	A	G	G	T	V	V	L	A	A	D	P	S	A	T	L	C	F	P	L	I	E	K	H	Q	V	N	V	T	A	L	V	P	P	A	V	S	L	W	L	Q	A	L	I	E	G	E	S	R	A	Q	L	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		S	L	K	L	L	Q	V	G	G	A	R	L	S	A	T	L	A	A	R	I	P	A	E	I	G	C	Q	L	Q	Q	V	F	G	M	A	E	G	L	V	N	Y	T	R	L	D	D	S	A	E	K	I	I	H	T	Q	G	Y	P	M	C
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		P	D	D	E	V	W	V	A	D	A	E	G	N	P	L	P	Q	G	E	V	G	R	L	M	T	R	G	P	Y	T	F	R	G	Y	Y	K	S	P	Q	H	N	A	S	A	F	D	A	N	G	F	Y	C	S	G	D	L	I	S	I	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		P	E	G	Y	I	T	V	Q	G	R	E	K	D	Q	I	N	R	G	G	E	K	I	A	A	E	E	I	E	N	L	L	L	R	H	P	A	V	I	Y	A	A	L	V	S	M	E	D	E	L	M	G	E	K	S	C	A	Y	L	V	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.
Sequence		K	E	P	L	R	A	V	Q	V	R	R	F	L	R	E	Q	G	I	A	E	F	K	L	P	D	R	V	E	C	V	D	S	L	P	L	T	A	V	G	K	V	D	K	K	Q	L	R	Q	W	L	A	S	R	A	S	A
Secondary structure
SS confidence
Disorder																																																						?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1mdb chain A Region: 5 - 536 Aligned: 528 Modelled: 532 Confidence: 100.0% Identity: 47% Fold: Acetyl-CoA synthetase-like Superfamily: Acetyl-CoA synthetase-like Family: Acetyl-CoA synthetase-like Phyre2 PDB 1pg4 chain A Region: 26 - 535 Aligned: 509 Modelled: 510 Confidence: 100.0% Identity: 21% Fold: Acetyl-CoA synthetase-like Superfamily: Acetyl-CoA synthetase-like Family: Acetyl-CoA synthetase-like Phyre2 PDB 1ry2 chain A Region: 25 - 532 Aligned: 507 Modelled: 508 Confidence: 100.0% Identity: 20% Fold: Acetyl-CoA synthetase-like Superfamily: Acetyl-CoA synthetase-like Family: Acetyl-CoA synthetase-like Phyre2 PDB 2vsq chain A Region: 10 - 536 Aligned: 502 Modelled: 506 Confidence: 100.0% Identity: 23% PDB header:ligase Chain: A: PDB Molecule:surfactin synthetase subunit 3; PDBTitle: structure of surfactin a synthetase c (srfa-c), a2 nonribosomal peptide synthetase termination module Phyre2 PDB 3cw9 chain A domain 1 Region: 25 - 531 Aligned: 495 Modelled: 507 Confidence: 100.0% Identity: 20% Fold: Acetyl-CoA synthetase-like Superfamily: Acetyl-CoA synthetase-like Family: Acetyl-CoA synthetase-like Phyre2 PDB 3e7w chain A Region: 25 - 535 Aligned: 492 Modelled: 493 Confidence: 100.0% Identity: 18% PDB header:ligase Chain: A: PDB Molecule:d-alanine--poly(phosphoribitol) ligase subunit 1; PDBTitle: crystal structure of dlta: implications for the reaction2 mechanism of non-ribosomal peptide synthetase (nrps)3 adenylation domains Phyre2 PDB 3ni2 chain A Region: 12 - 529 Aligned: 512 Modelled: 518 Confidence: 100.0% Identity: 20% PDB header:ligase Chain: A: PDB Molecule:4-coumarate:coa ligase; PDBTitle: crystal structures and enzymatic mechanisms of a populus tomentosa 4-2 coumarate:coa ligase Phyre2 PDB 1amu chain A Region: 10 - 528 Aligned: 489 Modelled: 502 Confidence: 100.0% Identity: 20% Fold: Acetyl-CoA synthetase-like Superfamily: Acetyl-CoA synthetase-like Family: Acetyl-CoA synthetase-like Phyre2 PDB 3eyn chain B Region: 28 - 530 Aligned: 492 Modelled: 503 Confidence: 100.0% Identity: 20% PDB header:ligase Chain: B: PDB Molecule:acyl-coenzyme a synthetase acsm2a; PDBTitle: crystal structure of human acyl-coa synthetase medium-chain2 family member 2a (l64p mutation) in a complex with coa Phyre2 PDB 3etc chain B Region: 10 - 515 Aligned: 499 Modelled: 503 Confidence: 100.0% Identity: 18% PDB header:ligase Chain: B: PDB Molecule:amp-binding protein; PDBTitle: 2.1 a structure of acyl-adenylate synthetase from methanosarcina2 acetivorans containing a link between lys256 and cys298 Phyre2 PDB 1amu chain B Region: 10 - 528 Aligned: 488 Modelled: 497 Confidence: 100.0% Identity: 19% PDB header:peptide synthetase Chain: B: PDB Molecule:gramicidin synthetase 1; PDBTitle: phenylalanine activating domain of gramicidin synthetase 12 in a complex with amp and phenylalanine Phyre2 PDB 2d1t chain A Region: 23 - 534 Aligned: 508 Modelled: 512 Confidence: 100.0% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:luciferin 4-monooxygenase; PDBTitle: crystal structure of the thermostable japanese firefly2 luciferase red-color emission s286n mutant complexed with3 high-energy intermediate analogue Phyre2 PDB 3dhv chain A Region: 27 - 532 Aligned: 484 Modelled: 490 Confidence: 100.0% Identity: 18% PDB header:ligase Chain: A: PDB Molecule:d-alanine-poly(phosphoribitol) ligase; PDBTitle: crystal structure of dlta protein in complex with d-alanine2 adenylate Phyre2 PDB 3gqw chain B Region: 26 - 536 Aligned: 495 Modelled: 497 Confidence: 100.0% Identity: 18% PDB header:ligase Chain: B: PDB Molecule:fatty acid amp ligase; PDBTitle: crystal structure of a fatty acid amp ligase from e. coli with an acyl2 adenylate product bound Phyre2 PDB 2v7b chain B Region: 25 - 528 Aligned: 480 Modelled: 491 Confidence: 100.0% Identity: 23% PDB header:ligase Chain: B: PDB Molecule:benzoate-coenzyme a ligase; PDBTitle: crystal structures of a benzoate coa ligase from2 burkholderia xenovorans lb400 Phyre2 PDB 3ite chain B Region: 24 - 527 Aligned: 478 Modelled: 491 Confidence: 100.0% Identity: 15% PDB header:ligase Chain: B: PDB Molecule:sidn siderophore synthetase; PDBTitle: the third adenylation domain of the fungal sidn non-2 ribosomal peptide synthetase Phyre2 PDB 3kxw chain A Region: 23 - 536 Aligned: 498 Modelled: 492 Confidence: 100.0% Identity: 16% PDB header:ligase Chain: A: PDB Molecule:saframycin mx1 synthetase b; PDBTitle: the crystal structure of fatty acid amp ligase from legionella2 pneumophila Phyre2 PDB 1lci chain A Region: 22 - 529 Aligned: 495 Modelled: 508 Confidence: 100.0% Identity: 19% Fold: Acetyl-CoA synthetase-like Superfamily: Acetyl-CoA synthetase-like Family: Acetyl-CoA synthetase-like Phyre2 PDB 3tsy chain A Region: 15 - 523 Aligned: 500 Modelled: 504 Confidence: 100.0% Identity: 19% PDB header:ligase, transferase Chain: A: PDB Molecule:fusion protein 4-coumarate--coa ligase 1, resveratrol PDBTitle: 4-coumaroyl-coa ligase::stilbene synthase fusion protein Phyre2 PDB 3l8c chain A Region: 25 - 530 Aligned: 479 Modelled: 488 Confidence: 100.0% Identity: 19% PDB header:ligase Chain: A: PDB Molecule:d-alanine--poly(phosphoribitol) ligase subunit 1; PDBTitle: structure of probable d-alanine--poly(phosphoribitol) ligase2 subunit-1 from streptococcus pyogenes Phyre2 1 d1mdba_ 2 d1pg4a_ 3 d1ry2a_ 4 c2vsqA_ 5 d3cw9a1 6 c3e7wA_ 7 c3ni2A_ 8 d1amua_ 9 c3eynB_ 10 c3etcB_ 11 c1amuB_ 12 c2d1tA_ 13 c3dhvA_ 14 c3gqwB_ 15 c2v7bB_ 16 c3iteB_ 17 c3kxwA_ 18 d1lcia_ 19 c3tsyA_ 20 c3l8cA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1mdba_ 100.0 47 Fold:Acetyl-CoA synthetase-like Superfamily:Acetyl-CoA synthetase-like Family:Acetyl-CoA synthetase-like 2 d1pg4a_ 100.0 21 Fold:Acetyl-CoA synthetase-like Superfamily:Acetyl-CoA synthetase-like Family:Acetyl-CoA synthetase-like 3 d1ry2a_ 100.0 20 Fold:Acetyl-CoA synthetase-like Superfamily:Acetyl-CoA synthetase-like Family:Acetyl-CoA synthetase-like 4 c2vsqA_ 100.0 23 PDB header:ligase Chain: A: PDB Molecule:surfactin synthetase subunit 3; PDBTitle: structure of surfactin a synthetase c (srfa-c), a2 nonribosomal peptide synthetase termination module 5 d3cw9a1 100.0 20 Fold:Acetyl-CoA synthetase-like Superfamily:Acetyl-CoA synthetase-like Family:Acetyl-CoA synthetase-like 6 c3e7wA_ 100.0 18 PDB header:ligase Chain: A: PDB Molecule:d-alanine--poly(phosphoribitol) ligase subunit 1; PDBTitle: crystal structure of dlta: implications for the reaction2 mechanism of non-ribosomal peptide synthetase (nrps)3 adenylation domains 7 c3ni2A_ 100.0 20 PDB header:ligase Chain: A: PDB Molecule:4-coumarate:coa ligase; PDBTitle: crystal structures and enzymatic mechanisms of a populus tomentosa 4-2 coumarate:coa ligase 8 d1amua_ 100.0 20 Fold:Acetyl-CoA synthetase-like Superfamily:Acetyl-CoA synthetase-like Family:Acetyl-CoA synthetase-like 9 c3eynB_ 100.0 20 PDB header:ligase Chain: B: PDB Molecule:acyl-coenzyme a synthetase acsm2a; PDBTitle: crystal structure of human acyl-coa synthetase medium-chain2 family member 2a (l64p mutation) in a complex with coa 10 c3etcB_ 100.0 18 PDB header:ligase Chain: B: PDB Molecule:amp-binding protein; PDBTitle: 2.1 a structure of acyl-adenylate synthetase from methanosarcina2 acetivorans containing a link between lys256 and cys298 11 c1amuB_ 100.0 19 PDB header:peptide synthetase Chain: B: PDB Molecule:gramicidin synthetase 1; PDBTitle: phenylalanine activating domain of gramicidin synthetase 12 in a complex with amp and phenylalanine 12 c2d1tA_ 100.0 18 PDB header:oxidoreductase Chain: A: PDB Molecule:luciferin 4-monooxygenase; PDBTitle: crystal structure of the thermostable japanese firefly2 luciferase red-color emission s286n mutant complexed with3 high-energy intermediate analogue 13 c3dhvA_ 100.0 18 PDB header:ligase Chain: A: PDB Molecule:d-alanine-poly(phosphoribitol) ligase; PDBTitle: crystal structure of dlta protein in complex with d-alanine2 adenylate 14 c3gqwB_ 100.0 18 PDB header:ligase Chain: B: PDB Molecule:fatty acid amp ligase; PDBTitle: crystal structure of a fatty acid amp ligase from e. coli with an acyl2 adenylate product bound 15 c2v7bB_ 100.0 23 PDB header:ligase Chain: B: PDB Molecule:benzoate-coenzyme a ligase; PDBTitle: crystal structures of a benzoate coa ligase from2 burkholderia xenovorans lb400 16 c3iteB_ 100.0 15 PDB header:ligase Chain: B: PDB Molecule:sidn siderophore synthetase; PDBTitle: the third adenylation domain of the fungal sidn non-2 ribosomal peptide synthetase 17 c3kxwA_ 100.0 16 PDB header:ligase Chain: A: PDB Molecule:saframycin mx1 synthetase b; PDBTitle: the crystal structure of fatty acid amp ligase from legionella2 pneumophila 18 d1lcia_ 100.0 19 Fold:Acetyl-CoA synthetase-like Superfamily:Acetyl-CoA synthetase-like Family:Acetyl-CoA synthetase-like 19 c3tsyA_ 100.0 19 PDB header:ligase, transferase Chain: A: PDB Molecule:fusion protein 4-coumarate--coa ligase 1, resveratrol PDBTitle: 4-coumaroyl-coa ligase::stilbene synthase fusion protein 20 c3l8cA_ 100.0 19 PDB header:ligase Chain: A: PDB Molecule:d-alanine--poly(phosphoribitol) ligase subunit 1; PDBTitle: structure of probable d-alanine--poly(phosphoribitol) ligase2 subunit-1 from streptococcus pyogenes 21 c3nyrA_ not modelled 100.0 27 PDB header:ligase Chain: A: PDB Molecule:malonyl-coa ligase; PDBTitle: malonyl-coa ligase ternary product complex with malonyl-coa and amp2 bound 22 c3iplB_ not modelled 100.0 24 PDB header:ligase Chain: B: PDB Molecule:2-succinylbenzoate--coa ligase; PDBTitle: crystal structure of o-succinylbenzoic acid-coa ligase from2 staphylococcus aureus subsp. aureus mu50 23 d1v25a_ not modelled 100.0 21 Fold:Acetyl-CoA synthetase-like Superfamily:Acetyl-CoA synthetase-like Family:Acetyl-CoA synthetase-like 24 c3g7sA_ not modelled 100.0 23 PDB header:ligase Chain: A: PDB Molecule:long-chain-fatty-acid--coa ligase (fadd-1); PDBTitle: crystal structure of a long-chain-fatty-acid-coa ligase2 (fadd1) from archaeoglobus fulgidus 25 c3o82B_ not modelled 100.0 53 PDB header:ligase Chain: B: PDB Molecule:peptide arylation enzyme; PDBTitle: structure of base n-terminal domain from acinetobacter baumannii bound2 to 5'-o-[n-(2,3-dihydroxybenzoyl)sulfamoyl] adenosine 26 c3o82A_ not modelled 100.0 53 PDB header:ligase Chain: A: PDB Molecule:peptide arylation enzyme; PDBTitle: structure of base n-terminal domain from acinetobacter baumannii bound2 to 5'-o-[n-(2,3-dihydroxybenzoyl)sulfamoyl] adenosine 27 c3ivrA_ not modelled 100.0 22 PDB header:ligase Chain: A: PDB Molecule:putative long-chain-fatty-acid coa ligase; PDBTitle: crystal structure of putative long-chain-fatty-acid coa ligase from2 rhodopseudomonas palustris cga009 28 c3e53A_ not modelled 100.0 17 PDB header:ligase Chain: A: PDB Molecule:fatty-acid-coa ligase fadd28; PDBTitle: crystal structure of n-terminal domain of a fatty acyl amp2 ligase faal28 from mycobacterium tuberculosis 29 c2y4oA_ not modelled 100.0 16 PDB header:ligase Chain: A: PDB Molecule:phenylacetate-coenzyme a ligase; PDBTitle: crystal structure of paak2 in complex with phenylacetyl adenylate 30 c2y27B_ not modelled 100.0 14 PDB header:ligase Chain: B: PDB Molecule:phenylacetate-coenzyme a ligase; PDBTitle: crystal structure of paak1 in complex with atp from2 burkholderia cenocepacia 31 c3qovD_ not modelled 100.0 15 PDB header:ligase Chain: D: PDB Molecule:phenylacetate-coenzyme a ligase; PDBTitle: crystal structure of a hypothetical acyl-coa ligase (bt_0428) from2 bacteroides thetaiotaomicron vpi-5482 at 2.20 a resolution 32 c3hguB_ not modelled 99.7 13 PDB header:biosynthetic protein Chain: B: PDB Molecule:ehpf; PDBTitle: structure of phenazine antibiotic biosynthesis protein 33 c3laxA_ not modelled 99.6 23 PDB header:ligase Chain: A: PDB Molecule:phenylacetate-coenzyme a ligase; PDBTitle: the crystal structure of a domain of phenylacetate-coenzyme2 a ligase from bacteroides vulgatus atcc 8482 34 d1f06a2 not modelled 82.4 21 Fold:FwdE/GAPDH domain-like Superfamily:Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Family:Dihydrodipicolinate reductase-like 35 d2ayia1 not modelled 76.3 13 Fold:Thermophilic metalloprotease-like Superfamily:Thermophilic metalloprotease-like Family:Thermophilic metalloprotease (M29) 36 d1pl8a2 not modelled 72.4 15 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 37 d1piwa2 not modelled 68.8 17 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 38 d1e3ja2 not modelled 65.7 19 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 39 c3smaD_ not modelled 65.2 30 PDB header:transferase Chain: D: PDB Molecule:frbf; PDBTitle: a new n-acetyltransferase fold in the structure and mechanism of the2 phosphonate biosynthetic enzyme frbf 40 c3e4fB_ not modelled 61.1 30 PDB header:transferase Chain: B: PDB Molecule:aminoglycoside n3-acetyltransferase; PDBTitle: crystal structure of ba2930- a putative aminoglycoside n3-2 acetyltransferase from bacillus anthracis 41 d1kola2 not modelled 60.1 16 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 42 d1z7wa1 not modelled 55.0 11 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 43 d1rjwa2 not modelled 54.2 15 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 44 d2nyga1 not modelled 53.6 25 Fold:TTHA0583/YokD-like Superfamily:TTHA0583/YokD-like Family:Aminoglycoside 3-N-acetyltransferase-like 45 d1d1ta2 not modelled 46.9 12 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 46 d1iz0a2 not modelled 45.1 22 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 47 d1fcja_ not modelled 42.3 12 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 48 d1llua2 not modelled 41.8 14 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 49 d1ykfa2 not modelled 41.8 15 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 50 d1uufa2 not modelled 40.7 15 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 51 d1e3ia2 not modelled 40.6 8 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 52 d1udxa3 not modelled 39.3 17 Fold:Obg GTP-binding protein C-terminal domain Superfamily:Obg GTP-binding protein C-terminal domain Family:Obg GTP-binding protein C-terminal domain 53 c3ippA_ not modelled 37.1 20 PDB header:transferase Chain: A: PDB Molecule:putative thiosulfate sulfurtransferase ynje; PDBTitle: crystal structure of sulfur-free ynje 54 d1jqba2 not modelled 35.9 13 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 55 d1p0fa2 not modelled 35.8 8 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 56 c1uarA_ not modelled 32.5 18 PDB header:transferase Chain: A: PDB Molecule:rhodanese; PDBTitle: crystal structure of rhodanese from thermus thermophilus hb8 57 d1jvba2 not modelled 32.0 15 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 58 c2ywiA_ not modelled 29.8 20 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical conserved protein; PDBTitle: crystal structure of uncharacterized conserved protein from2 geobacillus kaustophilus 59 c2jx2A_ not modelled 29.5 17 PDB header:transcription Chain: A: PDB Molecule:negative elongation factor e; PDBTitle: solution conformation of rna-bound nelf-e rrm 60 c2q3bA_ not modelled 28.9 8 PDB header:transferase Chain: A: PDB Molecule:cysteine synthase a; PDBTitle: 1.8 a resolution crystal structure of o-acetylserine sulfhydrylase2 (oass) holoenzyme from mycobacterium tuberculosis 61 d2fzwa2 not modelled 28.9 7 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 62 c3olhA_ not modelled 27.5 5 PDB header:transferase Chain: A: PDB Molecule:3-mercaptopyruvate sulfurtransferase; PDBTitle: human 3-mercaptopyruvate sulfurtransferase 63 d2jhfa2 not modelled 26.5 7 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 64 c3bcxA_ not modelled 26.4 23 PDB header:transferase Chain: A: PDB Molecule:cdp-6-deoxy-l-threo-d-glycero-4-hexulose-3- PDBTitle: e1 dehydrase 65 d1y7la1 not modelled 26.2 12 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 66 d1u3wa2 not modelled 25.4 8 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 67 d1cdoa2 not modelled 23.6 10 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 68 c3nnkC_ not modelled 23.2 11 PDB header:transferase Chain: C: PDB Molecule:ureidoglycine-glyoxylate aminotransferase; PDBTitle: biochemical and structural characterization of a ureidoglycine2 aminotransferase in the klebsiella pneumoniae uric acid catabolic3 pathway 69 d1zjca1 not modelled 23.1 10 Fold:Thermophilic metalloprotease-like Superfamily:Thermophilic metalloprotease-like Family:Thermophilic metalloprotease (M29) 70 c3l6cA_ not modelled 22.2 9 PDB header:isomerase Chain: A: PDB Molecule:serine racemase; PDBTitle: x-ray crystal structure of rat serine racemase in complex with2 malonate a potent inhibitor 71 d1yb5a2 not modelled 21.1 14 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 72 d1f8fa2 not modelled 21.1 10 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 73 d1pqwa_ not modelled 20.4 17 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 74 d1nula_ not modelled 19.3 14 Fold:PRTase-like Superfamily:PRTase-like Family:Phosphoribosyltransferases (PRTases) 75 d2bhsa1 not modelled 19.2 10 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 76 c2jkzB_ not modelled 19.1 21 PDB header:transferase Chain: B: PDB Molecule:hypoxanthine-guanine phosphoribosyltransferase; PDBTitle: saccharomyces cerevisiae hypoxanthine-guanine2 phosphoribosyltransferase in complex with gmp (guanosine 5'3 -monophosphate) (orthorhombic crystal form) 77 d1qora2 not modelled 19.1 15 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 78 d1v3va2 not modelled 19.0 25 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 79 c1okgA_ not modelled 19.0 12 PDB header:transferase Chain: A: PDB Molecule:possible 3-mercaptopyruvate sulfurtransferase; PDBTitle: 3-mercaptopyruvate sulfurtransferase from leishmania major 80 d1okga1 not modelled 17.4 12 Fold:Rhodanese/Cell cycle control phosphatase Superfamily:Rhodanese/Cell cycle control phosphatase Family:Multidomain sulfurtransferase (rhodanese) 81 d1ja1a1 not modelled 17.3 19 Fold:Reductase/isomerase/elongation factor common domain Superfamily:Riboflavin synthase domain-like Family:NADPH-cytochrome p450 reductase FAD-binding domain-like 82 d1l9xa_ not modelled 16.1 15 Fold:Flavodoxin-like Superfamily:Class I glutamine amidotransferase-like Family:Class I glutamine amidotransferases (GAT) 83 c1l9xA_ not modelled 16.1 15 PDB header:hydrolase Chain: A: PDB Molecule:gamma-glutamyl hydrolase; PDBTitle: structure of gamma-glutamyl hydrolase 84 c2zy3A_ not modelled 16.0 19 PDB header:lyase Chain: A: PDB Molecule:l-aspartate beta-decarboxylase; PDBTitle: dodecameric l-aspartate beta-decarboxylase 85 c3dwgA_ not modelled 15.8 7 PDB header:transferase Chain: A: PDB Molecule:cysteine synthase b; PDBTitle: crystal structure of a sulfur carrier protein complex found in the2 cysteine biosynthetic pathway of mycobacterium tuberculosis 86 c2uv0G_ not modelled 15.3 14 PDB header:transcription Chain: G: PDB Molecule:transcriptional activator protein lasr; PDBTitle: structure of the p. aeruginosa lasr ligand-binding domain2 bound to its autoinducer 87 c3aaxB_ not modelled 15.3 20 PDB header:transferase Chain: B: PDB Molecule:putative thiosulfate sulfurtransferase; PDBTitle: crystal structure of probable thiosulfate sulfurtransferase2 cysa3 (rv3117) from mycobacterium tuberculosis: monoclinic3 form 88 c2eguA_ not modelled 15.2 9 PDB header:transferase Chain: A: PDB Molecule:cysteine synthase; PDBTitle: crystal structure of o-acetylserine sulfhydrase from geobacillus2 kaustophilus hta426 89 d1uara2 not modelled 15.0 18 Fold:Rhodanese/Cell cycle control phosphatase Superfamily:Rhodanese/Cell cycle control phosphatase Family:Multidomain sulfurtransferase (rhodanese) 90 d1i1ga2 not modelled 14.7 16 Fold:Ferredoxin-like Superfamily:Dimeric alpha+beta barrel Family:Lrp/AsnC-like transcriptional regulator C-terminal domain 91 d1a3xa3 not modelled 14.7 20 Fold:Pyruvate kinase C-terminal domain-like Superfamily:PK C-terminal domain-like Family:Pyruvate kinase, C-terminal domain 92 d1v71a1 not modelled 14.6 11 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 93 d1qz9a_ not modelled 13.2 11 Fold:PLP-dependent transferase-like Superfamily:PLP-dependent transferases Family:Cystathionine synthase-like 94 d1liua3 not modelled 13.1 13 Fold:Pyruvate kinase C-terminal domain-like Superfamily:PK C-terminal domain-like Family:Pyruvate kinase, C-terminal domain 95 d1ve1a1 not modelled 13.0 12 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 96 d1f20a1 not modelled 12.9 26 Fold:Reductase/isomerase/elongation factor common domain Superfamily:Riboflavin synthase domain-like Family:NADPH-cytochrome p450 reductase FAD-binding domain-like 97 d1l3la2 not modelled 12.1 13 Fold:Profilin-like Superfamily:Pheromone-binding domain of LuxR-like quorum-sensing transcription factors Family:Pheromone-binding domain of LuxR-like quorum-sensing transcription factors 98 c3g8qA_ not modelled 11.9 17 PDB header:rna binding protein Chain: A: PDB Molecule:predicted rna-binding protein, contains thump PDBTitle: a cytidine deaminase edits c-to-u in transfer rnas in2 archaea 99 d1jjcb4 not modelled 11.6 24 Fold:Ferredoxin-like Superfamily:Anticodon-binding domain of PheRS Family:Anticodon-binding domain of PheRS

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Transmembrane helix prediction

Transmembrane helices have been predicted in your sequence to adopt the topology shown below

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0