BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (310 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_Q47690 Homocysteine S-methyltransferase n=56 Tax=Bacter... 630 e-179 UniRef50_O31463 Homocysteine S-methyltransferase ybgG n=13 Tax=B... 322 1e-86 UniRef50_Q4Q0C9 Homocysteine S-methyltransferase, putative n=3 T... 306 7e-82 UniRef50_B2VXK3 Homocysteine S-methyltransferase n=2 Tax=Pleospo... 304 3e-81 UniRef50_C4V3M8 Homocysteine S-methyltransferase n=5 Tax=Bacteri... 278 2e-73 UniRef50_Q1WRK4 Homocysteine S-methyltransferase n=10 Tax=Lactob... 275 1e-72 UniRef50_C6VP70 Homocysteine methyltransferase n=7 Tax=Bacteria ... 272 1e-71 UniRef50_A5VKC8 Homocysteine S-methyltransferase n=10 Tax=Lactob... 267 3e-70 UniRef50_UPI000050FD2A homocysteine methyltransferase n=1 Tax=Br... 252 1e-65 UniRef50_D2RKX3 Homocysteine S-methyltransferase n=2 Tax=Acidami... 248 1e-64 UniRef50_D1HYS9 Whole genome shotgun sequence of line PN40024, s... 248 2e-64 UniRef50_Q8LAX0 Homocysteine S-methyltransferase 3 n=52 Tax=Embr... 242 1e-62 UniRef50_B1MXY2 Homocysteine S-methyltransferase n=1 Tax=Leucono... 242 1e-62 UniRef50_C1F5Y3 Homocysteine S-methyltransferase n=1 Tax=Acidoba... 238 2e-61 UniRef50_Q1GBT8 Homocysteine S-methyltransferase n=2 Tax=Lactoba... 238 3e-61 UniRef50_B9E9X6 Putative uncharacterized protein n=1 Tax=Macroco... 237 4e-61 UniRef50_Q0BQM8 Homocysteine S-methyltransferase n=1 Tax=Granuli... 233 5e-60 UniRef50_Q5M5A7 Homocysteine S-methyltransferase (S-methylmethio... 232 1e-59 UniRef50_C8X6V8 Homocysteine S-methyltransferase n=14 Tax=Actino... 229 1e-58 UniRef50_A6G853 Homocysteine methyltransferase n=3 Tax=Bacteria ... 227 4e-58 UniRef50_D1BKY6 Homocysteine S-methyltransferase n=3 Tax=Veillon... 226 1e-57 UniRef50_B0RCV4 Homocysteine s-methyltransferase n=15 Tax=Actino... 225 1e-57 UniRef50_B0NWZ7 Putative uncharacterized protein n=1 Tax=Clostri... 225 2e-57 UniRef50_A8YVC8 Homocysteine S-methyltransferase n=2 Tax=Lactoba... 223 5e-57 UniRef50_A8KB71 Zgc:171603 protein n=4 Tax=Clupeocephala RepID=A... 221 4e-56 UniRef50_Q5PNQ3 Novel protein containing a homocysteine S-methyl... 215 2e-54 UniRef50_Q5ZBZ6 Os01g0772900 protein n=3 Tax=Magnoliophyta RepID... 215 2e-54 UniRef50_UPI0000DB6B54 PREDICTED: similar to CG10621-PA n=3 Tax=... 210 5e-53 UniRef50_C3ZEE1 Putative uncharacterized protein n=1 Tax=Branchi... 210 6e-53 UniRef50_B3S7K9 Putative uncharacterized protein n=1 Tax=Trichop... 210 6e-53 UniRef50_Q4S116 Chromosome 1 SCAF14770, whole genome shotgun seq... 208 2e-52 UniRef50_Q49V93 Putative homocysteine S-methyltransferase n=1 Ta... 204 3e-51 UniRef50_Q9VJ32 CG10621 n=19 Tax=Neoptera RepID=Q9VJ32_DROME 197 4e-49 UniRef50_A0APQ1 CG10623 protein n=22 Tax=Drosophila RepID=A0APQ1... 194 3e-48 UniRef50_Q2F5Q8 Homocysteine S-methyltransferase n=3 Tax=Endopte... 193 5e-48 UniRef50_C4R8J7 S-adenosylmethionine-homocysteine methyltransfer... 184 4e-45 UniRef50_A3TGH3 Homocysteine methyltransferase n=1 Tax=Janibacte... 183 8e-45 UniRef50_D0NSW2 Homocysteine S-methyltransferase, putative n=1 T... 179 2e-43 UniRef50_B9W8L8 Homocysteine S-methyltransferase, putative (S-me... 177 4e-43 UniRef50_UPI000180BE5F PREDICTED: similar to CG10623 CG10623-PA ... 174 5e-42 UniRef50_C3PEG0 Homocysteine S-methyltransferase n=3 Tax=Coryneb... 173 7e-42 UniRef50_C4XYV2 Putative uncharacterized protein n=1 Tax=Clavisp... 167 4e-40 UniRef50_C5MAR2 Putative uncharacterized protein n=1 Tax=Candida... 162 2e-38 UniRef50_Q6BZK6 DEHA2A00616p n=1 Tax=Debaryomyces hansenii RepID... 162 2e-38 UniRef50_Q6C0D6 YALI0F25641p n=1 Tax=Yarrowia lipolytica RepID=Q... 161 2e-38 UniRef50_D2S8U0 Homocysteine S-methyltransferase n=12 Tax=Actino... 159 1e-37 UniRef50_A8Q150 Probable homocysteine S-methyltransferase, putat... 158 2e-37 UniRef50_A3LQC9 AdoMet-homocysteine methyltransferase n=1 Tax=Pi... 154 4e-36 UniRef50_B1A1E6 Homocysteine methyltransferase (Fragment) n=1 Ta... 149 1e-34 UniRef50_A5DCB0 Putative uncharacterized protein n=2 Tax=Pichia ... 147 5e-34 UniRef50_Q08985 Homocysteine S-methyltransferase 2 n=17 Tax=Sacc... 147 5e-34 UniRef50_A7TSR2 Putative uncharacterized protein n=1 Tax=Vanderw... 145 1e-33 UniRef50_A5DTG6 Putative uncharacterized protein n=1 Tax=Loddero... 140 7e-32 UniRef50_C4QA25 Putative uncharacterized protein n=1 Tax=Schisto... 134 6e-30 UniRef50_B6KB25 Homocysteine S-methyltransferase-1 n=3 Tax=Toxop... 132 2e-29 UniRef50_B7G9Z1 Predicted protein n=1 Tax=Phaeodactylum tricornu... 130 5e-29 UniRef50_A4XIN5 Methylenetetrahydrofolate reductase n=1 Tax=Cald... 122 2e-26 UniRef50_UPI0000E4900F PREDICTED: similar to 5-methyltetrahydrof... 119 1e-25 UniRef50_Q753B4 AFR410Wp n=1 Tax=Eremothecium gossypii RepID=Q75... 117 6e-25 UniRef50_B8PAR1 Predicted protein (Fragment) n=1 Tax=Postia plac... 117 7e-25 UniRef50_C4WWI3 ACYPI009247 protein n=4 Tax=Acyrthosiphon pisum ... 115 1e-24 UniRef50_C1C2Y0 Homocysteine S-methyltransferase 1 n=1 Tax=Calig... 113 1e-23 UniRef50_B9MN09 Methylenetetrahydrofolate reductase n=2 Tax=root... 111 4e-23 UniRef50_C5E3E4 KLTH0H12716p n=1 Tax=Lachancea thermotolerans CB... 107 6e-22 UniRef50_Q28RZ7 Homocysteine S-methyltransferase n=13 Tax=Rhodob... 106 8e-22 UniRef50_Q2LWJ5 5-methyltetrahydrofolate--homocysteine methyltra... 106 1e-21 UniRef50_C8VHP4 Homocysteine S-methyltransferase (Eurofung) n=5 ... 106 1e-21 UniRef50_C6HW85 5-methyltetrahydrofolate--homocysteine methyltra... 105 3e-21 UniRef50_D2W5I3 Predicted protein (Fragment) n=2 Tax=Naegleria g... 104 4e-21 UniRef50_A4R5G4 Putative uncharacterized protein n=1 Tax=Magnapo... 103 5e-21 UniRef50_Q5PNQ2 Novel protein containing a homocysteine S-methyl... 103 6e-21 UniRef50_D1CBD0 Methylenetetrahydrofolate reductase n=1 Tax=Ther... 102 2e-20 UniRef50_A4J6L9 Methionine synthase (B12-dependent) n=1 Tax=Desu... 102 2e-20 UniRef50_B8CZI7 Homocysteine S-methyltransferase n=1 Tax=Halothe... 102 2e-20 UniRef50_D1Z559 Whole genome shotgun sequence assembly, scaffold... 102 2e-20 UniRef50_A9GUQ7 Putative homocysteine S-methyltransferase family... 100 7e-20 UniRef50_C1F3L2 Methylenetetrahydrofolate reductase n=2 Tax=Bact... 100 8e-20 UniRef50_UPI0001AEC485 homocysteine S-methyltransferase family p... 99 1e-19 UniRef50_A3ERA3 5-methyltetrahydrofolate--homocysteine methyltra... 99 2e-19 UniRef50_B0DTQ2 Predicted protein n=1 Tax=Laccaria bicolor S238N... 99 2e-19 UniRef50_B2AAZ0 Predicted CDS Pa_1_5620 n=2 Tax=Sordariales RepI... 99 3e-19 UniRef50_Q2S678 Vitamin B12-dependent methionine synthase family... 98 3e-19 UniRef50_B9XKW8 Methylenetetrahydrofolate reductase n=1 Tax=bact... 97 6e-19 UniRef50_B9L045 Methylenetetrahydrofolate reductase n=1 Tax=Ther... 97 6e-19 UniRef50_B4RRL7 Homocysteine S-methyltransferase family protein ... 96 2e-18 UniRef50_A1SWN6 Homocysteine S-methyltransferase n=1 Tax=Psychro... 96 2e-18 UniRef50_B8M2P0 Homocysteine S-methyltransferase, putative n=1 T... 95 3e-18 UniRef50_D2R929 Homocysteine S-methyltransferase n=1 Tax=Pirellu... 95 3e-18 UniRef50_A4XIN4 Homocysteine S-methyltransferase n=1 Tax=Caldice... 95 3e-18 UniRef50_B6AUX0 Homocysteine S-methyltransferase n=1 Tax=Rhodoba... 94 5e-18 UniRef50_D1B7X8 Homocysteine S-methyltransferase n=1 Tax=Therman... 94 8e-18 UniRef50_B5YB64 5-methyltetrahydrofolate-homocysteine methyltran... 94 8e-18 UniRef50_C6DY72 Homocysteine S-methyltransferase n=10 Tax=Desulf... 92 2e-17 UniRef50_Q01QP4 Methylenetetrahydrofolate reductase n=2 Tax=Acid... 92 2e-17 UniRef50_C8W2L3 Homocysteine S-methyltransferase n=1 Tax=Desulfo... 92 2e-17 UniRef50_Q30ZI4 Methionine synthase (B12-dependent) n=14 Tax=Des... 92 2e-17 UniRef50_Q15S12 Homocysteine S-methyltransferase n=1 Tax=Pseudoa... 92 3e-17 UniRef50_Q4DI99 Homocysteine S-methyltransferase, putative n=2 T... 92 3e-17 UniRef50_B8DYM9 Homocysteine S-methyltransferase n=1 Tax=Dictyog... 91 4e-17 UniRef50_C6D4G9 Methylenetetrahydrofolate reductase n=12 Tax=cel... 90 8e-17 UniRef50_B0K7W0 Homocysteine S-methyltransferase n=13 Tax=Firmic... 90 9e-17 UniRef50_A1WU24 Homocysteine S-methyltransferase n=7 Tax=Proteob... 90 1e-16 UniRef50_B9NLU8 Homocysteine S-methyltransferase family protein ... 90 1e-16 UniRef50_A9FZY9 Methylenetetrahydrofolate reductase n=1 Tax=Sora... 89 1e-16 UniRef50_A6G2A6 Homocysteine S-methyltransferase, putative n=1 T... 89 2e-16 UniRef50_Q4FMM0 Homocysteine S-methyltransferase n=2 Tax=Candida... 89 2e-16 UniRef50_Q5KA93 Homocysteine S-methyltransferase, putative n=1 T... 89 3e-16 UniRef50_A1AKP7 Methylenetetrahydrofolate reductase n=10 Tax=Des... 88 5e-16 UniRef50_A9B657 Methylenetetrahydrofolate reductase n=1 Tax=Herp... 87 7e-16 UniRef50_Q2JJL4 Methionine synthase n=30 Tax=Bacteria RepID=Q2JJ... 87 7e-16 UniRef50_D1N227 Methylenetetrahydrofolate reductase n=1 Tax=Vict... 86 2e-15 UniRef50_B7I892 Homocysteine S-methyltransferase family protein ... 86 2e-15 UniRef50_B7VQ49 Homocysteine S-methyltransferase family protein ... 86 2e-15 UniRef50_A0Q0N0 5-methyltetrahydrofolate--homocysteine methyltra... 86 2e-15 UniRef50_B3E428 Methionine synthase n=91 Tax=Bacteria RepID=B3E4... 85 3e-15 UniRef50_B7Q2S9 5-methyltetrahydrofolate:homocysteine methyltran... 85 3e-15 UniRef50_Q4PDM6 Putative uncharacterized protein n=1 Tax=Ustilag... 85 3e-15 UniRef50_A2R696 Contig An15c0240, complete genome n=9 Tax=Leotio... 85 3e-15 UniRef50_Q2LQ11 Methylenetetrahydrofolate reductase n=1 Tax=Synt... 84 5e-15 UniRef50_A6S563 Putative uncharacterized protein n=2 Tax=Sclerot... 84 5e-15 UniRef50_Q67LG1 5-methyltetrahydrofolate S-homocysteine methyltr... 84 6e-15 UniRef50_Q1AXR8 Methylenetetrahydrofolate reductase n=2 Tax=Bact... 84 6e-15 UniRef50_A5ZUF2 Putative uncharacterized protein n=2 Tax=Clostri... 83 1e-14 UniRef50_D1Y627 Homocysteine S-methyltransferase n=1 Tax=Pyramid... 83 1e-14 UniRef50_C3XLV5 S-methyltransferase n=2 Tax=Helicobacter RepID=C... 83 1e-14 UniRef50_C0QY88 5-methyltetrahydrofolate--homocysteine methyltra... 82 2e-14 UniRef50_C9SAQ6 Homocysteine S-methyltransferase n=1 Tax=Vertici... 82 3e-14 UniRef50_A9B073 Methionine synthase n=2 Tax=Bacteria RepID=A9B07... 81 4e-14 UniRef50_A5IKF3 Methionine synthase (B12-dependent) n=6 Tax=Ther... 80 8e-14 UniRef50_B9MN08 Homocysteine S-methyltransferase n=1 Tax=Anaeroc... 79 2e-13 UniRef50_C9KQD5 Vitamin B12-dependent methionine synthase family... 78 3e-13 UniRef50_C0QE32 Methionine synthase I, cobalamin-binding domain ... 78 3e-13 UniRef50_Q04898 Putative uncharacterized protein YMR321C n=2 Tax... 78 4e-13 UniRef50_Q4GZ92 Homocysteine S-methyltransferase, putative n=2 T... 78 4e-13 UniRef50_A6TTI3 Homocysteine S-methyltransferase n=6 Tax=Firmicu... 77 5e-13 UniRef50_C1SMZ8 5-methyltetrahydrofolate--homocysteine methyltra... 77 6e-13 UniRef50_A4EBI1 Putative uncharacterized protein n=1 Tax=Collins... 77 7e-13 UniRef50_Q0TQI2 Homocysteine S-methyltransferase family protein ... 77 8e-13 UniRef50_D1BQ67 Homocysteine S-methyltransferase n=4 Tax=Veillon... 77 8e-13 UniRef50_B8FX16 Homocysteine S-methyltransferase n=2 Tax=Desulfi... 77 1e-12 UniRef50_C0D4W7 Putative uncharacterized protein n=3 Tax=Clostri... 76 1e-12 UniRef50_B6BT42 Homocysteine S-methyltransferase 4, putative n=1... 76 1e-12 UniRef50_A7T8D2 Predicted protein n=1 Tax=Nematostella vectensis... 76 1e-12 UniRef50_UPI000190A21A homocysteine S-methyltransferase n=2 Tax=... 76 1e-12 UniRef50_A8N5L5 Putative uncharacterized protein n=1 Tax=Coprino... 76 2e-12 UniRef50_C3RK90 Homocysteine S-methyltransferase n=3 Tax=Bacteri... 76 2e-12 UniRef50_A3JFK5 Putative uncharacterized protein n=1 Tax=Marinob... 76 2e-12 UniRef50_Q65V50 MHT1 protein n=3 Tax=Pasteurellaceae RepID=Q65V5... 75 2e-12 UniRef50_C1EAX2 Predicted protein n=36 Tax=cellular organisms Re... 75 2e-12 UniRef50_A8SPV0 Methylenetetrahydrofolate reductase n=2 Tax=Clos... 75 2e-12 UniRef50_UPI0001BCEC92 bifunctional homocysteine S-methyltransfe... 75 3e-12 UniRef50_C6LEJ3 Vitamin B12-dependent methionine synthase family... 75 4e-12 UniRef50_UPI0001BC6543 5-methyltetrahydrofolate--homocysteine me... 75 4e-12 UniRef50_Q024B4 Homocysteine S-methyltransferase n=2 Tax=Bacteri... 75 4e-12 UniRef50_A8M0Q1 Homocysteine S-methyltransferase n=3 Tax=Actinom... 74 6e-12 UniRef50_C7NB07 Methionine synthase n=6 Tax=Leptotrichia RepID=C... 74 8e-12 UniRef50_Q0AX05 Methionine synthase (B12-dependent) n=1 Tax=Synt... 74 9e-12 UniRef50_O06745 5,10-methylenetetrahydrofolate reductase n=78 Ta... 74 9e-12 UniRef50_A6DGP4 5-methyltetrahydrofolate--homocysteine methyltra... 73 1e-11 UniRef50_B2A781 Homocysteine S-methyltransferase n=1 Tax=Natrana... 73 2e-11 UniRef50_UPI00017B4C9F UPI00017B4C9F related cluster n=1 Tax=Tet... 73 2e-11 UniRef50_Q1NSQ8 Methylenetetrahydrofolate reductase n=3 Tax=Delt... 72 2e-11 UniRef50_A7VWF8 Putative uncharacterized protein n=1 Tax=Clostri... 72 3e-11 UniRef50_A9A1I5 Homocysteine S-methyltransferase n=2 Tax=Thaumar... 72 3e-11 UniRef50_B6GAW1 Putative uncharacterized protein n=1 Tax=Collins... 72 3e-11 UniRef50_Q6AL45 Related to 5-methyltetrahydrofolate--homocystein... 71 4e-11 UniRef50_C4GEB4 Methylenetetrahydrofolate reductase n=1 Tax=Shut... 71 5e-11 UniRef50_D2RMA2 Homocysteine S-methyltransferase n=13 Tax=Bacter... 70 7e-11 UniRef50_C6JIG3 Methionine synthase n=3 Tax=Fusobacterium RepID=... 70 7e-11 UniRef50_C0EVI7 Methylenetetrahydrofolate reductase n=1 Tax=Euba... 70 8e-11 UniRef50_C0QRY9 Methionine synthase n=3 Tax=Bacteria RepID=C0QRY... 70 1e-10 UniRef50_C3WBE7 Methionine synthase n=1 Tax=Fusobacterium mortif... 70 1e-10 UniRef50_C4GEB2 Putative uncharacterized protein n=1 Tax=Shuttle... 70 1e-10 UniRef50_B9DIA5 Methylenetetrahydrofolate reductase n=10 Tax=Sta... 70 1e-10 UniRef50_A6QBA6 5-methyltetrahydrofolate--homocysteine methyltra... 69 1e-10 UniRef50_B6YR37 Cobalamin-dependent methionine synthase n=1 Tax=... 69 2e-10 UniRef50_B3QGP3 Methionine synthase n=71 Tax=cellular organisms ... 69 2e-10 UniRef50_C3MDS4 Homocysteine S-methyltransferase, putative n=12 ... 69 3e-10 UniRef50_Q99707 Methionine synthase n=289 Tax=cellular organisms... 68 4e-10 UniRef50_B4DST3 cDNA FLJ56487, highly similar to Methionine synt... 68 4e-10 UniRef50_B7ZLW7 MTR protein n=1 Tax=Homo sapiens RepID=B7ZLW7_HUMAN 68 4e-10 UniRef50_Q8DUN2 Methylenetetrahydrofolate reductase n=12 Tax=Str... 68 5e-10 UniRef50_A7VPD0 Methylenetetrahydrofolate reductase n=1 Tax=Clos... 67 6e-10 UniRef50_Q7M929 S-METHYLTRANSFERASE n=1 Tax=Wolinella succinogen... 67 6e-10 UniRef50_UPI0001C311AB homocysteine S-methyltransferase n=1 Tax=... 67 7e-10 UniRef50_B8I366 Homocysteine S-methyltransferase n=1 Tax=Clostri... 67 7e-10 UniRef50_A5UPF4 Methionine synthase (B12-dependent) n=5 Tax=Chlo... 67 9e-10 UniRef50_D0LSQ2 Methylenetetrahydrofolate reductase n=1 Tax=Hali... 67 9e-10 UniRef50_C7LX76 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 67 1e-09 UniRef50_Q146H9 Methionine synthase (B12-dependent) n=21 Tax=cel... 66 1e-09 UniRef50_C6W4B8 Methionine synthase n=4 Tax=Bacteria RepID=C6W4B... 66 1e-09 UniRef50_Q55786 Methionine synthase n=14 Tax=Cyanobacteria RepID... 66 1e-09 UniRef50_UPI0001BC43AA B12-dependent methionine synthase n=1 Tax... 66 1e-09 UniRef50_B7AQD9 Methylenetetrahydrofolate reductase n=1 Tax=Bact... 65 3e-09 UniRef50_A4WQF1 Homocysteine S-methyltransferase n=39 Tax=Alphap... 65 3e-09 UniRef50_Q5UEY6 Putative homocysteine S-methyltransferase family... 65 3e-09 UniRef50_C7JFY7 Methionine synthase n=8 Tax=Acetobacter pasteuri... 65 4e-09 UniRef50_Q5SKM5 5-methyltetrahydrofolate homocysteine S-methyltr... 65 4e-09 UniRef50_Q01YW7 Methionine synthase (B12-dependent) n=5 Tax=Bact... 64 5e-09 UniRef50_A9KSG0 Homocysteine S-methyltransferase n=7 Tax=Clostri... 64 6e-09 UniRef50_A8SP62 Putative uncharacterized protein n=2 Tax=Clostri... 64 6e-09 UniRef50_Q5N5P4 5-methyltetrahydrofolate--homocysteine methyltra... 64 6e-09 UniRef50_B6K6T6 Homocysteine methyltransferase n=1 Tax=Schizosac... 64 7e-09 UniRef50_B1KCG4 Homocysteine S-methyltransferase n=52 Tax=Proteo... 63 1e-08 UniRef50_D2PQB9 Methionine synthase n=2 Tax=Actinomycetales RepI... 63 1e-08 UniRef50_A8SCX4 Methylenetetrahydrofolate reductase n=3 Tax=Clos... 63 1e-08 UniRef50_UPI0001C31EF9 homocysteine S-methyltransferase n=1 Tax=... 63 2e-08 UniRef50_D2UDY2 Probable 5-methyltetrahydrofolate-homocysteine m... 63 2e-08 UniRef50_C9M596 Vitamin B12-dependent methionine synthase family... 62 2e-08 UniRef50_Q5E814 Methionine synthase n=458 Tax=Bacteria RepID=MET... 62 2e-08 UniRef50_D0MU48 Methionine synthase n=1 Tax=Phytophthora infesta... 62 2e-08 UniRef50_C0ADK0 Homocysteine S-methyltransferase n=1 Tax=Opituta... 62 2e-08 UniRef50_UPI000196BD90 hypothetical protein CATMIT_02259 n=1 Tax... 62 2e-08 UniRef50_A4J5C2 Methylenetetrahydrofolate reductase n=5 Tax=Clos... 62 3e-08 UniRef50_Q1CZ82 Homocysteine S-methyltransferase domain protein ... 62 3e-08 UniRef50_B4DBI1 Homocysteine S-methyltransferase n=1 Tax=Chthoni... 62 3e-08 UniRef50_P74718 Slr1189 protein n=1 Tax=Synechocystis sp. PCC 68... 61 4e-08 UniRef50_Q966F6 Putative uncharacterized protein T13G4.4 n=3 Tax... 61 5e-08 UniRef50_A7RIN6 Predicted protein n=5 Tax=Eumetazoa RepID=A7RIN6... 60 9e-08 UniRef50_B0PG09 Putative uncharacterized protein n=1 Tax=Anaerot... 60 9e-08 UniRef50_D0NMR8 Putative uncharacterized protein n=1 Tax=Phytoph... 60 1e-07 UniRef50_B0MM61 Putative uncharacterized protein n=1 Tax=Eubacte... 60 1e-07 UniRef50_A8LTT9 Homocysteine S-methyltransferase n=7 Tax=Rhodoba... 60 1e-07 UniRef50_UPI00016C59CA 5-methyltetrahydrofolate--homocysteine S-... 60 1e-07 UniRef50_A6LKZ2 Homocysteine S-methyltransferase n=6 Tax=Bacteri... 60 1e-07 UniRef50_B0TAJ7 Methionine synthase, putative n=1 Tax=Heliobacte... 59 2e-07 UniRef50_C4Z117 Methylenetetrahydrofolate reductase n=1 Tax=Euba... 59 2e-07 UniRef50_B7G6P4 Predicted protein n=2 Tax=cellular organisms Rep... 59 3e-07 UniRef50_B1H0N5 Homocysteine S-methyltransferase n=1 Tax=uncultu... 58 3e-07 UniRef50_C0ZBM1 5-methyltetrahydrofolate--homocysteine methyltra... 58 4e-07 UniRef50_A5TSW8 Methionine synthase n=9 Tax=Fusobacterium RepID=... 58 4e-07 UniRef50_A4EKV4 Methionine synthase I n=4 Tax=Alphaproteobacteri... 58 5e-07 UniRef50_C8WWX3 Methylenetetrahydrofolate reductase n=2 Tax=Alic... 57 1e-06 UniRef50_B1HTR8 Methylenetetrahydrofolate reductase n=95 Tax=Bac... 57 1e-06 UniRef50_B0PF81 Methylenetetrahydrofolate reductase n=1 Tax=Anae... 56 1e-06 UniRef50_P87138 Uncharacterized protein C57A7.07c n=1 Tax=Schizo... 56 2e-06 UniRef50_B8I637 Methylenetetrahydrofolate reductase n=2 Tax=Clos... 55 2e-06 UniRef50_UPI0000E47473 PREDICTED: hypothetical protein n=2 Tax=S... 55 2e-06 UniRef50_B8J7W9 Methionine synthase n=3 Tax=Anaeromyxobacter Rep... 55 5e-06 UniRef50_UPI00016C0A13 5-methyltetrahydrofolate--homocysteine me... 54 8e-06 UniRef50_C3XWR9 Putative uncharacterized protein n=5 Tax=Branchi... 54 9e-06 UniRef50_C6VPC5 Methylenetetrahydrofolate reductase n=3 Tax=Lact... 53 1e-05 UniRef50_A5N923 Methylenetetrahydrofolate reductase n=2 Tax=Clos... 53 1e-05 UniRef50_A8TIL6 Methionine synthase I n=3 Tax=Proteobacteria Rep... 53 1e-05 UniRef50_A1DJI9 Homocysteine S-methyltransferase, putative n=4 T... 53 1e-05 UniRef50_C3Y7W3 Putative uncharacterized protein n=3 Tax=Branchi... 53 2e-05 UniRef50_B5JEM8 Homocysteine S-methyltransferase, putative n=1 T... 52 2e-05 UniRef50_C1XT53 Methionine synthase (B12-dependent) n=2 Tax=Meio... 52 3e-05 UniRef50_A7SKT1 Predicted protein n=4 Tax=Eumetazoa RepID=A7SKT1... 51 4e-05 UniRef50_A0Z513 Putative uncharacterized protein n=1 Tax=marine ... 51 4e-05 >UniRef50_Q47690 Homocysteine S-methyltransferase n=56 Tax=Bacteria RepID=MMUM_ECOLI Length = 310 Score = 630 bits (1626), Expect = e-179, Method: Compositional matrix adjust. Identities = 310/310 (100%), Positives = 310/310 (100%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR Sbjct: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG Sbjct: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA Sbjct: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQ 240 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQ Sbjct: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQ 240 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP Sbjct: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 Query: 301 ADIAALKARS 310 ADIAALKARS Sbjct: 301 ADIAALKARS 310 >UniRef50_O31463 Homocysteine S-methyltransferase ybgG n=13 Tax=Bacteria RepID=HMT_BACSU Length = 315 Score = 322 bits (825), Expect = 1e-86, Method: Compositional matrix adjust. Identities = 161/308 (52%), Positives = 214/308 (69%), Gaps = 6/308 (1%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 NP++ +LD +++LDGAMATELE +GCNL DSLWSAK+L+E PELI++VH DY+ AGA Sbjct: 2 NPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEEPELIKQVHTDYFAAGAD 61 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAY--LAENP-QAGTLLVAGS 121 CAITASYQ+T GFAARGL EA+++ LI SV +A +AR+ + L EN ++A S Sbjct: 62 CAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDEFWSLEENRLNRPKPIIAAS 121 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 +GPYGAYLADGSEYRG+Y S + FHRPR++AL++AGAD+LACET+P +E +A+ Sbjct: 122 IGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEAGADVLACETIPCLTEAKAIVR 181 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQH 241 LL +P AW SF+ +D H+SDGTP D + L + Q+ ALGINC L++ + ++ Sbjct: 182 LLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDEHRQIAALGINCTPLQHIPSLIEE 241 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQ-LADYLPQWQAAGARLIGGCCRTTP 300 L T P++VYPNSGE YD +KTW +G CA+ W GARLIGGCCRT P Sbjct: 242 LKKNTSKPIIVYPNSGEQYDPETKTW--NGAACAESYGASARTWHEKGARLIGGCCRTKP 299 Query: 301 ADIAALKA 308 +I + A Sbjct: 300 ENIQEIAA 307 >UniRef50_Q4Q0C9 Homocysteine S-methyltransferase, putative n=3 Tax=Leishmania RepID=Q4Q0C9_LEIMA Length = 339 Score = 306 bits (783), Expect = 7e-82, Method: Compositional matrix adjust. Identities = 160/302 (52%), Positives = 202/302 (66%), Gaps = 8/302 (2%) Query: 10 LLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITA 69 L D +++LDG +ATELE RGC+L D LWS KVL+E+P+ ++ V L Y RAGA+C ITA Sbjct: 24 LADPNYVVMLDGGLATELETRGCDLRDPLWSGKVLLESPQQLQNVALAYLRAGARCIITA 83 Query: 70 SYQATPAGFAA-RGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 SYQ TP R L E + A I +SV +A+ ARE +L E PQA + VAGSVGPYGAY Sbjct: 84 SYQITPQSLMEHRRLTEDAAVAAIEESVRIAQSARERHLREKPQAAPIFVAGSVGPYGAY 143 Query: 129 LADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT-AYP 187 LADGSEYRGDY S E F+ FHR R+ ALL AGAD+LA ET P+ +E+ A+ LL +P Sbjct: 144 LADGSEYRGDYVRSAEEFKEFHRLRIAALLRAGADVLAIETQPSAAEVRAIVALLQEEHP 203 Query: 188 RARAWFSFT---LRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHG 244 RAW SFT + E +SDGT D+++ L PQ+VA+G+NCI + +A L HLH Sbjct: 204 NCRAWVSFTTSRISPVEAISDGTKWADIISFLEKAPQIVAVGVNCIPMAEASAVLAHLHT 263 Query: 245 LTVLPLVVYPNSGEHYDAVSKTWH---HHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 LT +PLVVY NSGE YDAV++TWH L +W + GARL+GGCCRT P+ Sbjct: 264 LTTMPLVVYTNSGESYDAVTRTWHPISMSDGTTLSLGALAREWASHGARLVGGCCRTGPS 323 Query: 302 DI 303 DI Sbjct: 324 DI 325 >UniRef50_B2VXK3 Homocysteine S-methyltransferase n=2 Tax=Pleosporineae RepID=B2VXK3_PYRTR Length = 319 Score = 304 bits (779), Expect = 3e-81, Method: Compositional matrix adjust. Identities = 156/308 (50%), Positives = 209/308 (67%), Gaps = 5/308 (1%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 N L A + K L+LDGA+AT LE G +++ +LWSA +L++ P LI++ HLDYYRA A Sbjct: 8 NRLSAHIVKGSPLILDGALATYLETLGADISGALWSASILLDQPSLIKQTHLDYYRANAN 67 Query: 65 CAITASYQATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQ--AGTLLVAGS 121 AITASYQA+ G L+E ++K ++ KSVELA++AR+ Y+ E+ L +AGS Sbjct: 68 VAITASYQASIPGLVKHLQLNEKEAKDVVKKSVELAQEARDQYITESTAKVGNQLFIAGS 127 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 VGPYGA+LADGSEYRGDY E + FHR R++AL++AG D+LACET+P+ +E EA+ + Sbjct: 128 VGPYGAFLADGSEYRGDYSIPKEEMKDFHRGRIQALVEAGVDILACETIPSKAETEAIID 187 Query: 182 LLTA-YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQ 240 LLT + AWF FTLRDSEH+SDGT L ++ AL QVVALG NC+ + + AAL+ Sbjct: 188 LLTTEFASTEAWFGFTLRDSEHISDGTSLAEIAALFDNVQQVVALGFNCVPDDLSVAALK 247 Query: 241 HLHGLTVL-PLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 L L LVVYPNSGE ++A ++ W + LA+ +W+ AGA LIGGCCRTT Sbjct: 248 TLKPLVKRGTLVVYPNSGEQWNAQAREWEGKRTEGSSLAEKTREWRDAGAGLIGGCCRTT 307 Query: 300 PADIAALK 307 P DI +K Sbjct: 308 PKDIGVMK 315 >UniRef50_C4V3M8 Homocysteine S-methyltransferase n=5 Tax=Bacteria RepID=C4V3M8_9FIRM Length = 349 Score = 278 bits (710), Expect = 2e-73, Method: Compositional matrix adjust. Identities = 151/306 (49%), Positives = 194/306 (63%), Gaps = 5/306 (1%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 N L L QD+L+LDGA+ATELEARG ++ D LWSAK L E P+L+R++HLDY RAGA Sbjct: 19 NVLEVRLAAQDVLVLDGALATELEARGFSVDDPLWSAKALFERPDLVRDIHLDYLRAGAD 78 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTL-LVAGSVG 123 +ASYQAT GF RG ++ L+ +SV LA++AR Y AE + LVA SVG Sbjct: 79 VLTSASYQATVDGFMQRGFTAEEAAELLRRSVRLAQEARGLYRAERSTGTAVPLVAASVG 138 Query: 124 PYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 PYGAYLADGSEYRGDY +A AFH R+ L A DLLACETLP E A+ L Sbjct: 139 PYGAYLADGSEYRGDYDVEEDALTAFHAQRLRILASAAPDLLACETLPCLHEACAIVRSL 198 Query: 184 TAYP-RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHL 242 A R A+FSF+ RD H+SDGT + + +L P+ A+G+NC A + + ++ + Sbjct: 199 RAEGIRIPAYFSFSCRDGAHISDGTEIAECARVLDAVPEAAAIGVNCTAPQYVSGLIRMI 258 Query: 243 HGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPAD 302 T P+VVYPNSGE+YDA ++ W E + ++ AAGAR+IGGCCRTTP D Sbjct: 259 RQETDKPIVVYPNSGEYYDAAARVWRGAAEDFGARSR---EYAAAGARIIGGCCRTTPHD 315 Query: 303 IAALKA 308 AA+ A Sbjct: 316 TAAIAA 321 >UniRef50_Q1WRK4 Homocysteine S-methyltransferase n=10 Tax=Lactobacillus RepID=Q1WRK4_LACS1 Length = 307 Score = 275 bits (704), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 136/291 (46%), Positives = 188/291 (64%), Gaps = 4/291 (1%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 ++LDGAM+T LE G + + LW+AK L++N EL+ E+H Y+ AGA IT +YQA Sbjct: 12 VVLDGAMSTPLERLGADTNNDLWTAKALIDNEELVYEIHKMYFEAGADLIITDTYQANVQ 71 Query: 77 GFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYR 136 F G E +++ LI K+V++A+KAR+ Y EN +AG++GPYGAYLA+GSEYR Sbjct: 72 AFEKVGYSEKEARNLIKKAVKIAQKARDDY--ENRTGKHNYIAGTIGPYGAYLANGSEYR 129 Query: 137 GDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL-TAYPRARAWFSF 195 GDY SVE +Q FH PR+E L++A D+LA ET P E+ A+ ELL YP+ + + S+ Sbjct: 130 GDYELSVEEYQQFHLPRIEELVNAEVDILAIETQPKLDEVLAILELLKKKYPQQKVYVSY 189 Query: 196 TLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYPN 255 TL D + +SDGTPL + L Y QV+A+GINC+ LE AL+++ +T L+VYPN Sbjct: 190 TLSDDDTISDGTPLPRAIHALEDYSQVIAVGINCVKLELVEPALKNMKEITDKHLIVYPN 249 Query: 256 SGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 S YD SKTW + A + +P W AGAR+IGGCC T P +I A+ Sbjct: 250 SSAVYDPKSKTW-SQPKTSATFEELIPNWYEAGARIIGGCCTTGPKEIKAV 299 >UniRef50_C6VP70 Homocysteine methyltransferase n=7 Tax=Bacteria RepID=C6VP70_LACPJ Length = 309 Score = 272 bits (695), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 137/292 (46%), Positives = 187/292 (64%), Gaps = 9/292 (3%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 ++ DGAMATELE RG +LWSA ++++P+ I+ VH Y AGA+ T +YQA Sbjct: 13 VVSDGAMATELEKRGVATNSALWSATAMLDHPDAIQAVHQSYLDAGAKIMTTNTYQANVP 72 Query: 77 GFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYR 136 F G+ AQ++ LI ++V +A AR+A + ++AGS+GPYGAYLADGSEY Sbjct: 73 AFEQAGIAAAQARQLIQQAVTIAHTARDASHVTDA-----VIAGSIGPYGAYLADGSEYT 127 Query: 137 GDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA-YPRARAWFSF 195 G Y + A+Q FHR R+ ++ AG D+LA ET+P E++AL +L+T +P+ W SF Sbjct: 128 GAYQLTPSAYQDFHRERLALIMAAGVDVLALETMPRLDEVQALVQLITTTWPQQPYWVSF 187 Query: 196 TLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYPN 255 +++D + L DGT L +A P VVA+G+NC LEN AL L +PL+VYPN Sbjct: 188 SIKDPQTLCDGTSLAAAAKWVAAQPNVVAVGVNCTTLENIAPALTTLKAAVAVPLIVYPN 247 Query: 256 SGEHYDAVSKTWH-HHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 SG+ YD V+KTW H H Q A ++PQW AAGAR+IGGCCRTTP DIA + Sbjct: 248 SGDQYDPVTKTWQATHLSH--QFASFVPQWLAAGARIIGGCCRTTPKDIATV 297 >UniRef50_A5VKC8 Homocysteine S-methyltransferase n=10 Tax=Lactobacillus RepID=A5VKC8_LACRD Length = 310 Score = 267 bits (683), Expect = 3e-70, Method: Compositional matrix adjust. Identities = 137/292 (46%), Positives = 186/292 (63%), Gaps = 6/292 (2%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 LL+DGAM+T LE G + +SLW+A VL P L+++VH +Y++AG + AIT +YQA Sbjct: 12 LLIDGAMSTALEQLGADTNNSLWTASVLANQPALVKKVHQEYFKAGDRLAITDTYQANVP 71 Query: 77 GFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYR 136 F G + ++ +LI ++V LA++AR+ Y E VAG++GPYGAYLA+GSEY Sbjct: 72 AFIKNGYSKQEAHSLIQRAVVLAKEARDEYQQETGIYN--YVAGALGPYGAYLANGSEYS 129 Query: 137 GDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY-PRARAWFSF 195 G YH S +Q FHRPR+ +L G D++A ET P E+ A +L+ P + SF Sbjct: 130 GAYHLSTIEYQQFHRPRLTDILTVGVDVIAIETQPRLDEVLAELDLVKELAPDTLCYVSF 189 Query: 196 TLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYPN 255 +L+DS HL DGTPL +A Y V A+G+NCI LE TAA++ +H +T P++ YPN Sbjct: 190 SLKDSTHLPDGTPLAVAARTVAKYTNVFAVGVNCIPLEEVTAAIETVHQVTEKPVIAYPN 249 Query: 256 SGEHYDAVSKTWHH-HGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 S YD +KTW + HG L DYLPQW AAG ++GGCC TTP DIAAL Sbjct: 250 SSATYDPTTKTWSYPHGRRG--LVDYLPQWIAAGLIIVGGCCTTTPQDIAAL 299 >UniRef50_UPI000050FD2A homocysteine methyltransferase n=1 Tax=Brevibacterium linens BL2 RepID=UPI000050FD2A Length = 308 Score = 252 bits (644), Expect = 1e-65, Method: Compositional matrix adjust. Identities = 149/314 (47%), Positives = 188/314 (59%), Gaps = 21/314 (6%) Query: 1 MSQN--NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDY 58 MSQ + L+A + D L++DG + T LE+RG +L+ LWSA +L ++P+ + EVH D+ Sbjct: 1 MSQTFIHLLQAAVRSGDPLVIDGGLGTALESRGIDLSHELWSAALLRDSPDTLAEVHADF 60 Query: 59 YRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLV 118 RAGAQ TASYQATP GF + + LI +SVE+A A +A LV Sbjct: 61 IRAGAQIVTTASYQATPLGFERASIPAEEGLRLIARSVEIAAGAGDA-----------LV 109 Query: 119 AGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 AGSVGPYGA L +G+EY GDYH S E F AFHRPR+EAL++AGADLLA ET P+ SEI Sbjct: 110 AGSVGPYGAALGNGAEYTGDYHLSDEEFAAFHRPRIEALVNAGADLLAIETQPSLSEITV 169 Query: 179 LAELLTAYPRARAWFSFT------LRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIAL 232 LA L Y AW S T L D H++D TPL D+ +A + A+G+NC+ Sbjct: 170 LAGLADEY-GIPAWLSVTLADQGDLADGSHMADRTPLSDLAEAVADSRMIRAVGVNCVRP 228 Query: 233 ENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLI 292 AL L T LPL+ YPNSGE YDA + W + P W +AG R+I Sbjct: 229 SLVAPALAALASATDLPLIAYPNSGETYDAATMEWREDSAFDTSPSTLAP-WVSAGVRII 287 Query: 293 GGCCRTTPADIAAL 306 GGCCRTTPADIA L Sbjct: 288 GGCCRTTPADIAGL 301 >UniRef50_D2RKX3 Homocysteine S-methyltransferase n=2 Tax=Acidaminococcus RepID=D2RKX3_ACIFE Length = 317 Score = 248 bits (634), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 139/302 (46%), Positives = 188/302 (62%), Gaps = 11/302 (3%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 L+ +LD+ IL++DG+M T LE G +L +SLW+A+VL PEL+++VHLDY+RAGA Sbjct: 5 LKNILDQNKILVIDGSMGTALENLGADLNNSLWTARVLANRPELVKQVHLDYFRAGADAG 64 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAG----TLLVAGSV 122 IT SYQA+ G A G E +++ LI +SV + ++AR+ + +A L +AG V Sbjct: 65 ITCSYQASIPGLVANGFTEQEAEELITRSVTIFQEARQEWWDREGKAAGRAWPLCLAG-V 123 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GPYGAYLADGSEYRG Y S E + FHR R E L AGAD+L ET P+ EAL E+ Sbjct: 124 GPYGAYLADGSEYRGHYGVSREDLEKFHRRRAELLWQAGADVLLFETQPSLE--EALVEV 181 Query: 183 LTAYPRARA-WFSFTLRDSEHLSDGTPLRDVVA-LLAGYPQVVALGINCIALENTTAALQ 240 A A W SF+ RD H+ +GTP+R+ A ++ +P+V ALG+NC E + + Sbjct: 182 SIAKDLGAAFWVSFSCRDGLHICEGTPIREAAAEVVRQFPEVEALGVNCTKPEYLVSLIG 241 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 L + P+ VYPNSGE YD V+KTWH G + DY ++ AGA +GGCC TT Sbjct: 242 ELKTASDRPIFVYPNSGEEYDPVTKTWHGVGTD-RKFGDYALEYMKAGAVAVGGCC-TTV 299 Query: 301 AD 302 AD Sbjct: 300 AD 301 >UniRef50_D1HYS9 Whole genome shotgun sequence of line PN40024, scaffold_20.assembly12x (Fragment) n=6 Tax=rosids RepID=D1HYS9_VITVI Length = 330 Score = 248 bits (633), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 140/299 (46%), Positives = 182/299 (60%), Gaps = 11/299 (3%) Query: 18 LLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPAG 77 ++DG +ATELE G +L D LWSA L+ +P+LIR VHLDY AGA ITASYQAT G Sbjct: 24 VIDGGLATELERHGADLNDPLWSATCLIHSPDLIRRVHLDYLEAGASIIITASYQATIQG 83 Query: 78 FAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGT------LLVAGSVGPYGAYLAD 131 F A+GL +++ L+ +SVE+A +AR+ Y E GT +LVA SVG YGAYLAD Sbjct: 84 FEAKGLSREEAEVLLRRSVEIACEARDIY-HERCAKGTCLEQRPILVAASVGSYGAYLAD 142 Query: 132 GSEYRGDYHCSV--EAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYP-R 188 GSEY G Y +V E + FHR RV+ L ++GADL+A ET+PN E +A AELL + Sbjct: 143 GSEYSGHYGAAVTLETLKDFHRRRVQVLAESGADLIAFETIPNKLEAKAYAELLDEENIK 202 Query: 189 ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVL 248 AWFSFT D ++ G L + ++ QVVA+GINC + + +T Sbjct: 203 IPAWFSFTSLDGINVVSGDSLIECASIADSCKQVVAVGINCTPPRFIHGLILLIQKVTTK 262 Query: 249 PLVVYPNSGEHYDAVSKTW-HHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 P+V+YPNSGE YD V K W G Y+ +W+ AGA L GGCCRT+P I A+ Sbjct: 263 PVVIYPNSGETYDGVRKEWVKSSGVQDGDFVSYVSKWREAGASLFGGCCRTSPHTIRAI 321 >UniRef50_Q8LAX0 Homocysteine S-methyltransferase 3 n=52 Tax=Embryophyta RepID=HMT3_ARATH Length = 347 Score = 242 bits (618), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 136/305 (44%), Positives = 178/305 (58%), Gaps = 16/305 (5%) Query: 18 LLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPAG 77 ++DG ATEL+ G ++ D LWSAK L+ +P L+ +VHLDY +GA ITASYQAT G Sbjct: 25 VVDGGFATELQRHGADINDPLWSAKCLITSPHLVTKVHLDYLESGANIIITASYQATIQG 84 Query: 78 FAARGLDEAQSKALIGKSVELARKAREAYLAENPQAG------------TLLVAGSVGPY 125 F A+GL +++ L+ +SVE+ +ARE + + +LVA SVG Y Sbjct: 85 FVAKGLSVGEAENLLRRSVEITYEAREIFYNRCTKGSWDFAYAGKASRRPILVAASVGSY 144 Query: 126 GAYLADGSEYRGDYHCSV--EAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 GAYLADGSEY G Y SV E + FHR RV+ L +GADL+A ET+PN E EA A+LL Sbjct: 145 GAYLADGSEYSGIYGDSVSKETLKDFHRRRVQILAKSGADLIAFETIPNKLEAEAYADLL 204 Query: 184 TAYP-RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHL 242 AWFSFT +D + G + + + VVA+GINC A A + L Sbjct: 205 EEEDIDIPAWFSFTSKDGVSVPRGDSVVECAKVADSCKNVVAIGINCTAPRYIHALIISL 264 Query: 243 HGLTVLPLVVYPNSGEHYDAVSKTW-HHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 +T P+VVYPNSGE YD ++K W GE Y+ +W+ AGA L GGCCRTTP Sbjct: 265 RQMTRKPIVVYPNSGEVYDGLNKKWIKSEGESEEDFVSYVSKWRDAGASLFGGCCRTTPN 324 Query: 302 DIAAL 306 I A+ Sbjct: 325 TIRAI 329 >UniRef50_B1MXY2 Homocysteine S-methyltransferase n=1 Tax=Leuconostoc citreum KM20 RepID=B1MXY2_LEUCK Length = 303 Score = 242 bits (617), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 126/294 (42%), Positives = 179/294 (60%), Gaps = 13/294 (4%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 Q ++LDG + +E++ + +A++LWSA L++ P L+R++H Y+ AGAQ AI +YQA Sbjct: 10 QGPVILDGGLGSEIDKQHIAVANNLWSASALIQAPNLVRDIHQSYFNAGAQIAIVDTYQA 69 Query: 74 TPAGFAARGLDEAQSKALIGKSVELAR---KAREAYLAENPQAGTLLVAGSVGPYGAYLA 130 P F GL E ++ LI +V LAR K E L ++AGSVGPYGAYLA Sbjct: 70 HPQTFVDSGLSENEAYELIDLAVALARDGLKKSEKSLG--------IIAGSVGPYGAYLA 121 Query: 131 DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL-TAYPRA 189 +G+EY GDY S++A+QAFHR R++ L+ D+LA ET+PNF E +A+A LL +P Sbjct: 122 NGAEYTGDYDLSIQAYQAFHRQRIKRLVHNNVDILALETMPNFKEAQAIALLLQNEFPEV 181 Query: 190 RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLP 249 A+ SF +HL DGT L VA + Q+ A+GINC A +N A+ + T Sbjct: 182 EAYLSFATEVGDHLWDGTRLAHAVAYFNQFEQIKAIGINCTAPDNILPAIMRIKPNTDKK 241 Query: 250 LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADI 303 +++YPN+GE Y+ +K W + E +P WQ AGA +IGGCCRT+P DI Sbjct: 242 VILYPNAGEVYNPETKRWVTNNEPI-NWRRLVPLWQHAGADIIGGCCRTSPEDI 294 >UniRef50_C1F5Y3 Homocysteine S-methyltransferase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F5Y3_ACIC5 Length = 310 Score = 238 bits (606), Expect = 2e-61, Method: Compositional matrix adjust. Identities = 129/291 (44%), Positives = 171/291 (58%), Gaps = 5/291 (1%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 I +LDG MATELE RG N++ LWSA VL E+PE I+ VHLDY RAG+ C T SYQ + Sbjct: 12 IRVLDGGMATELERRGFNISGPLWSAHVLDESPEAIQAVHLDYLRAGSDCISTVSYQISA 71 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 G+A + + +SV LA +AR Y EN + + +A S+GPYGA L +G+E+ Sbjct: 72 QGYAELSRPDPAFATALRRSVALAEEARARYAQENSR--PIWIAASLGPYGAALHNGAEF 129 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 G+Y + + FHR R+ L + GADL+A ET+P+ E A+ LT P AW SF Sbjct: 130 HGNYSITFDDLVEFHRARLAVLAETGADLVAFETIPSLDEARAILTALTHTPNVSAWLSF 189 Query: 196 TLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYPN 255 T RD H++ G PL LL QV+ALGINC A + L T P++ YPN Sbjct: 190 TCRDEAHIAHGEPLAACAQLLDSAVQVLALGINCTAPRHVAPLLAAAQSQTRKPVIAYPN 249 Query: 256 SGEHYDAVSKTWHHHGEHCAQLADYLP---QWQAAGARLIGGCCRTTPADI 303 SGE ++A ++ W + A++ DY QW AAGA+ IGGCCRTTP I Sbjct: 250 SGESWNAATRAWQGRTDLAAEVKDYQTLAGQWFAAGAQAIGGCCRTTPEHI 300 >UniRef50_Q1GBT8 Homocysteine S-methyltransferase n=2 Tax=Lactobacillus delbrueckii subsp. bulgaricus RepID=Q1GBT8_LACDA Length = 310 Score = 238 bits (606), Expect = 3e-61, Method: Compositional matrix adjust. Identities = 138/296 (46%), Positives = 179/296 (60%), Gaps = 5/296 (1%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 Q + LDG+M+T LEA G + LW+AK L +NP+L+ VH +Y++AGA+ IT SYQA Sbjct: 10 QGPVTLDGSMSTPLEAWGEDTNSDLWTAKALADNPDLVYRVHQEYFKAGARVTITDSYQA 69 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 + F GL E ++ALI +S +A KAR+ + E VAGSVGPYGAYLADGS Sbjct: 70 SLPAFMKHGLSEDAARALIRESAAVAIKARDDF--EKETGIHNFVAGSVGPYGAYLADGS 127 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA-YPRARAW 192 EYRGDY S E + FH PR+E L+ G D LA ET P SE+ A+ + L A YP + Sbjct: 128 EYRGDYALSHEEYVDFHAPRIEELVAGGVDCLAVETQPKLSEVRAILDYLKAKYPDLPVY 187 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVV 252 SF+L+D +S+G PL + V ++ Y QV A G NC L T +++L + LP+VV Sbjct: 188 VSFSLKDPATISEGLPLTEAVEEVSAYAQVFAAGANCFKLAWTVDVVKNLRA-SKLPIVV 246 Query: 253 YPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 YPNSG YD K W + E A W AAGA+L+GGCC T P DIA L A Sbjct: 247 YPNSGAEYDPSVKKWVYPPE-AADFGQAGAAWLAAGAKLVGGCCTTMPEDIAGLAA 301 >UniRef50_B9E9X6 Putative uncharacterized protein n=1 Tax=Macrococcus caseolyticus JCSC5402 RepID=B9E9X6_MACCJ Length = 295 Score = 237 bits (605), Expect = 4e-61, Method: Compositional matrix adjust. Identities = 115/294 (39%), Positives = 176/294 (59%), Gaps = 11/294 (3%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 +QDI++LDG T +E G ++ LWS+ ++ NPE + +VH + +GA+ +T +YQ Sbjct: 8 QQDIVILDGGFGTTVEQFGYDVKHELWSSNLIQSNPEAVYKVHKAFVDSGAEIILTNTYQ 67 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A+ F G+D+A + + +VELA +A + ++AGS+GPYGA L +G Sbjct: 68 ASVQSFLNIGIDKATACTYLATAVELATRA---------ASNRTIIAGSLGPYGAMLGNG 118 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 SEY GDY + + +H+ R++ L++AG + A ET+PN EI+A+ LL YP AW Sbjct: 119 SEYTGDYEETEADYIQYHKERLDILIEAGVSVFAFETIPNIEEIKAVRTLLLDYPHIEAW 178 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVV 252 S TL+D +HLSDGTPL V+ ++ V+A G+NC ++ AA+ L L+ PL++ Sbjct: 179 ISVTLKDHDHLSDGTPLEAVIEVVNEIENVLAFGVNCTSVNVIDAAVDKLITLSDKPLIL 238 Query: 253 YPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 YPNSG YDAV K W + A L + P+W+ G ++IGGCC+ P +I L Sbjct: 239 YPNSGRQYDAVHKVWIDQED--ASLVEAAPRWKEKGVKIIGGCCQVGPGEIKEL 290 >UniRef50_Q0BQM8 Homocysteine S-methyltransferase n=1 Tax=Granulibacter bethesdensis CGDNIH1 RepID=Q0BQM8_GRABC Length = 313 Score = 233 bits (595), Expect = 5e-60, Method: Compositional matrix adjust. Identities = 136/306 (44%), Positives = 179/306 (58%), Gaps = 9/306 (2%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 + +L + LLLDGA+ATELE G +L D LWS ++L++NP I VH Y AGA C Sbjct: 5 ISSLFRQARPLLLDGALATELERAGYHLDDPLWSGRLLLDNPAAIAAVHRAYLEAGADCI 64 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTL-----LVAGS 121 TASYQ + G RGL ++ +++ + LA R+ A P A LVAGS Sbjct: 65 ETASYQLSLPGLQRRGLSRGRAMSVLADAARLACSVRDDVWAGLPAAQRRNRIRPLVAGS 124 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 +GPYGA ADGSEY G Y S + AFH PR+ AL GADL+ACET+P+ E A A+ Sbjct: 125 LGPYGACQADGSEYTGRYALSRSQYLAFHAPRMRALAAGGADLIACETVPHLDEALAFAD 184 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQH 241 LL A W SF++RD+ H++DGTPLR V +A P V A+GINC A ++ Sbjct: 185 LLQALS-VPGWVSFSVRDAAHIADGTPLRLCVQAMASCPFVAAIGINCTDPVLVPALIRC 243 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 L LP++VYPN+GE +D V++ W H A+ W GAR++GGCCRT P Sbjct: 244 LR-RGGLPVIVYPNAGEPFDLVTRCWGHRRSD--DWAEQARSWLRLGARIVGGCCRTRPD 300 Query: 302 DIAALK 307 DI AL+ Sbjct: 301 DIRALR 306 >UniRef50_Q5M5A7 Homocysteine S-methyltransferase (S-methylmethionine) n=21 Tax=Streptococcus RepID=Q5M5A7_STRT2 Length = 322 Score = 232 bits (592), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 133/310 (42%), Positives = 186/310 (60%), Gaps = 13/310 (4%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 + L+ L+L GA+ TE+EA G +++ LWSAK L+E E+I+E+H Y AGA Sbjct: 10 FKDYLENNSPLILHGALGTEMEALGYDISGKLWSAKYLLEKSEVIQELHETYVAAGADLI 69 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAY---LAENPQAGT--LLVAGS 121 T+SYQAT G GL E ++ +I +V LA+ AR+ L E +A L++G Sbjct: 70 TTSSYQATLPGLVEAGLTEKAAEQIIALTVRLAKAARDKVWGALDETEKAKRPYPLISGD 129 Query: 122 VGPYGAYLADGSEYRGDY-HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 VGPY AYLA+GSEY GDY +++ + FHRPR++ LLD G DLLA ET+PN E +AL Sbjct: 130 VGPYAAYLANGSEYSGDYGQITIKELKDFHRPRIQILLDQGVDLLALETIPNRLETQALI 189 Query: 181 ELLT-AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIA--LENTTA 237 ELL +P A A+ SFT++ + +SDGT L ++ L++ Q++A+GINC + L N Sbjct: 190 ELLAEEFPEAEAYMSFTVQIPDAISDGTSLAEMAKLVSQSNQILAVGINCSSPLLYNQAL 249 Query: 238 ALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQA-AGARLIGGCC 296 A G L+ YPNSGE YD S+TW + L ++ W A G +++GGCC Sbjct: 250 AFLKNAGKA---LITYPNSGEVYDGDSQTWKPKDKDALTLVEHSKYWHAHFGVKILGGCC 306 Query: 297 RTTPADIAAL 306 RT P DI AL Sbjct: 307 RTRPNDIKAL 316 >UniRef50_C8X6V8 Homocysteine S-methyltransferase n=14 Tax=Actinomycetales RepID=C8X6V8_NAKMY Length = 320 Score = 229 bits (584), Expect = 1e-58, Method: Compositional matrix adjust. Identities = 139/300 (46%), Positives = 184/300 (61%), Gaps = 16/300 (5%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 L+LDG +AT LEA G +L +LWSA++LV+NP I H +Y+RAGAQ AITASYQA+ Sbjct: 16 LVLDGGLATLLEAHGHDLTSALWSAQLLVQNPGAITAAHREYFRAGAQVAITASYQASLP 75 Query: 77 GFAARGLDEAQSKALIGKSVELARKAREAYLAE--NPQAGTLLVAGSVGPYGAYLADGSE 134 G AA GL +++ + +SV+LAR A + E P +G VA SVGPYGA LADGSE Sbjct: 76 GLAAIGLGRVEAEQALRRSVDLARTAAADGVNEATAPGSGPRWVATSVGPYGAALADGSE 135 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 YRGDY +V + +HRPR+E L DAG D+LA ET+P +E+EAL + A A AW S Sbjct: 136 YRGDYGLTVRQLRDWHRPRLEILADAGGDVLAIETIPCAAEVEALLTEIQAL-DAPAWLS 194 Query: 195 FTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYP 254 T +D + G + +V A+ AG QV+A+G+NC+ + + P VVYP Sbjct: 195 LTCQDGRTRA-GERVDEVFAMAAGVDQVIAVGVNCVESAEAADLVAAAAENSGKPAVVYP 253 Query: 255 NSGEHYDAVSKTWHHHGEHCAQLADYLPQ----WQAAGARLIGGCCRTTPADIAALKARS 310 NSGE +DA ++ W A A + P+ W A+GARL+GGCCR P I L ARS Sbjct: 254 NSGEDWDAQARAW-------AGRATFGPEHAAVWVASGARLVGGCCRVGPQAIRRL-ARS 305 >UniRef50_A6G853 Homocysteine methyltransferase n=3 Tax=Bacteria RepID=A6G853_9DELT Length = 325 Score = 227 bits (578), Expect = 4e-58, Method: Compositional matrix adjust. Identities = 147/311 (47%), Positives = 184/311 (59%), Gaps = 18/311 (5%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 L LL ++ +LDG +AT LEA GC+L D LWSA++L+++PE +R VH + AGA Sbjct: 11 LDRLLAREPFAVLDGGLATSLEACGCDLDDPLWSARLLLDDPEALRTVHRRWRDAGADIL 70 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 TASYQA+ G A+GL EA++KAL+ +SV L R A + A P L+A SVG YG Sbjct: 71 ATASYQASLPGLRAKGLSEARAKALLRESVTLTRAAADEANAPRP-----LIAASVGSYG 125 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 AYLADGSEYRG Y SVEA FHRPR+ L AG DL+A ET P+ E+ ALAELLT Sbjct: 126 AYLADGSEYRGGYGLSVEALADFHRPRLLELAAAGPDLIAFETFPDAVELAALAELLTEL 185 Query: 187 PRA------RAWFSFTLRD-----SEHLSDGTPLRDVVALLAGYPQVVALGINCIALENT 235 RAW S +L S L+DGTPL +A L +P+V ALG+NC+ Sbjct: 186 LTELGDTLPRAWISASLSPPGPDRSVRLADGTPLTKALAPLTDHPKVAALGVNCVGPREV 245 Query: 236 TAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGC 295 AL+ L T PLV YPNSGE + + + W + A +W GARLIGGC Sbjct: 246 APALEVLAACTDRPLVAYPNSGERW--IDRGWSGAALEPNKFAALAERWFELGARLIGGC 303 Query: 296 CRTTPADIAAL 306 CRT A I AL Sbjct: 304 CRTNYAHIQAL 314 >UniRef50_D1BKY6 Homocysteine S-methyltransferase n=3 Tax=Veillonella RepID=D1BKY6_VEIPT Length = 341 Score = 226 bits (575), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 121/337 (35%), Positives = 186/337 (55%), Gaps = 31/337 (9%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M++ + ++ ++D L+LDGA+ TELE GC++ LWSAKVL++ P++I+++H+ Y Sbjct: 5 MAKRSAFLDIIKEKDALVLDGALGTELERYGCDIQHKLWSAKVLMDQPDIIKKIHISYLA 64 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYL------------- 107 AGA ++ YQAT AGF G ++ L+ SV LA +AR +L Sbjct: 65 AGADIIQSSGYQATVAGFKGLGYGTEEAIELVKLSVRLAVQARNEFLEAKASGALTLRGI 124 Query: 108 ---AENPQA------GTL---LVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVE 155 E P+ G L LVA SVGPYGA+LADGSEYRG E + FH PR+ Sbjct: 125 KLGEETPEGVKYFSEGALPKPLVAASVGPYGAFLADGSEYRGYPDVQTEYLEVFHIPRLA 184 Query: 156 ALLDAGADLLACETLPNFSEIEALAELLTAYPRAR---AWFSFTLRDSEHLSDGTPLRDV 212 + D+L+ ET+P+++E A+A ++ ++ AW +F+ +D H+S G + Sbjct: 185 LFCEENPDILSFETIPSYAEAIAIARAMSDPFTSKGIPAWIAFSCKDGHHVSSGETIIKC 244 Query: 213 VALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGE 272 ++ + +GINC E + ++ + +T P+ VYPN GE YD+ +KTW+ Sbjct: 245 AQMIDKVHPITGIGINCTKPEYVESLIKDIRTVTDKPIAVYPNLGESYDSKTKTWYG--- 301 Query: 273 HCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKAR 309 A DY+ W+ AGA +IGGCCRTTP I + + Sbjct: 302 DAASFVDYVEVWRKAGAEIIGGCCRTTPEIIGDIAKK 338 >UniRef50_B0RCV4 Homocysteine s-methyltransferase n=15 Tax=Actinomycetales RepID=B0RCV4_CLAMS Length = 301 Score = 225 bits (574), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 130/293 (44%), Positives = 176/293 (60%), Gaps = 9/293 (3%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 L+LDG + T LEARG +L+D LWSA+VL + P+ +R H +Y+RAGA AITASYQ Sbjct: 12 LVLDGGLGTLLEARGHDLSDPLWSARVLADEPDAVRAAHAEYFRAGADVAITASYQVGFE 71 Query: 77 GFAARGLDEAQSKALIGKSVELARKAREAYLAEN-PQAG-TLLVAGSVGPYGAYLADGSE 134 FAARGL A+++ L+ SV LA +AR+ ++ P AG +A SVGPYGA L DGSE Sbjct: 72 AFAARGLSAAETEELLRASVRLAAEARDEVAQDDAPGAGRDRWIAASVGPYGATLGDGSE 131 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 Y + + +H PR L D+GADLLACET+P+ E AL +L A AW + Sbjct: 132 YAASSGLTRAELRRWHAPRFAVLADSGADLLACETVPSLDEGRALVDLARGS-GASAWLA 190 Query: 195 FTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYP 254 FT++ L G P+ + L G ++VA+GINC E AA+ G+T P+ VYP Sbjct: 191 FTVQGG-RLRSGEPMAEGFRLANGADEIVAVGINCAHPEEVPAAIAAARGVTDRPVAVYP 249 Query: 255 NSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 NSGE +DAV++ W G+ D W AAGA ++GGCCR P +I ++ Sbjct: 250 NSGERWDAVARAW--GGDPALPSVD---AWIAAGASIVGGCCRVGPDEIRRMR 297 >UniRef50_B0NWZ7 Putative uncharacterized protein n=1 Tax=Clostridium sp. SS2/1 RepID=B0NWZ7_9CLOT Length = 319 Score = 225 bits (573), Expect = 2e-57, Method: Compositional matrix adjust. Identities = 117/305 (38%), Positives = 174/305 (57%), Gaps = 8/305 (2%) Query: 4 NNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGA 63 N + ++ + I+++DG+M+T LE RG +L LW+AK+L E PELI++VH +Y++AGA Sbjct: 3 KNSIENIIKENKIMVIDGSMSTPLENRGVSLNSKLWTAKILAEQPELIKQVHKNYFKAGA 62 Query: 64 QCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTL---LVAG 120 C IT SYQA+ G G +++ LI +V++ +AR+ + E + L G Sbjct: 63 DCGITCSYQASIPGLMENGYTLEEAENLIRSAVKIFCEARDEWWEEEGREARRAWPLCLG 122 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 + GPYGAYLADGSEYRG+Y + E + FH+ RVE L +AGAD++ ET+P+ E + A Sbjct: 123 AAGPYGAYLADGSEYRGNYGITDEQLKEFHKRRVELLHEAGADIILFETVPSLKEAKVEA 182 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLA-GYPQVVALGINCIALENTTAAL 239 E+ Y W SF+ + +GTP+ + A GYP + +G+NC E T + Sbjct: 183 EIAEEYGY-DYWISFSCLSENIICEGTPIAECATTFAKGYPHLKMIGVNCTKPEYITGLI 241 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCA-QLADYLPQWQAAGARLIGGCCRT 298 + +P+ VYPNSGE YDAV K W G+ A Y + +GA +GGCC T Sbjct: 242 HKIKENCDIPIGVYPNSGEEYDAVKKVW--FGKQSALSFEQYAYNYMKSGASAVGGCCTT 299 Query: 299 TPADI 303 + Sbjct: 300 VAKHV 304 >UniRef50_A8YVC8 Homocysteine S-methyltransferase n=2 Tax=Lactobacillus helveticus RepID=A8YVC8_LACH4 Length = 331 Score = 223 bits (569), Expect = 5e-57, Method: Compositional matrix adjust. Identities = 120/294 (40%), Positives = 164/294 (55%), Gaps = 10/294 (3%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 ++LDGAM+ ELE +G + LW+A L+ + I + H DY+ AGA+ IT +YQA Sbjct: 42 IVLDGAMSDELERQGVKTNNKLWTATALINELDKIYQAHWDYFTAGAELVITDTYQANVQ 101 Query: 77 GFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYR 136 F G E +++ I +V++A+KAR+ Y E VAG+VG Y AYLADG+EYR Sbjct: 102 AFTQAGYSEQEAEKFIRDAVKVAKKARDDY--EQKTGKHNYVAGTVGSYSAYLADGNEYR 159 Query: 137 GDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE----IEALAELLTAYPRARAW 192 GDY S + AFH PR+ +L DL+A ET P E + L E + YP + Sbjct: 160 GDYELSELEYLAFHLPRLRQILAEKPDLIALETQPKLDEPLAVLNWLKENASDYP---VY 216 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVV 252 SFTL+D+ H+SDGT L V+ + + QV A+GINCI+ + AL+ + T PLV+ Sbjct: 217 VSFTLKDATHISDGTTLEQAVSAVDKFEQVFAIGINCISPDLVAPALKEIGKYTFKPLVL 276 Query: 253 YPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 YPN G YD K W E +W GARLIGGCC T P +I + Sbjct: 277 YPNLGASYDPKIKQWREFKEKF-DFNKLTKKWYQEGARLIGGCCTTGPTEIKQM 329 >UniRef50_A8KB71 Zgc:171603 protein n=4 Tax=Clupeocephala RepID=A8KB71_DANRE Length = 311 Score = 221 bits (562), Expect = 4e-56, Method: Compositional matrix adjust. Identities = 122/299 (40%), Positives = 179/299 (59%), Gaps = 11/299 (3%) Query: 17 LLLDGAMATELEARGCNL-ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 +LDG +ATELEA G L D LWSA+VL +P+ I++VH Y ++G+ TA+YQA+ Sbjct: 10 FILDGGLATELEASGFLLQGDPLWSARVLHTDPQAIKDVHYRYLQSGSDVITTATYQASI 69 Query: 76 AGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQAGTL--LVAGSVGPYGAYLADG 132 GF G+ +++ ++ +V+LA++ +++++P + LVAGSVGPYG++L DG Sbjct: 70 EGFVKYLGVQPEEAQHMMMSAVQLAKETVSEFISQSPMSDRREPLVAGSVGPYGSFLHDG 129 Query: 133 SEYRGDYH--CSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRAR 190 SEY G Y +VE + +HRP+++ L+ AGADL+A ET+P E EAL E+L +P + Sbjct: 130 SEYTGAYEDKMTVEELKDWHRPQIQCLVKAGADLVAMETIPGLKEAEALVEVLKEFPETK 189 Query: 191 AWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQ--HLHGLTVL 248 AW SF+ +D+ +S G + V + Q+VA+G+NC L+ H L Sbjct: 190 AWLSFSCKDNNSISSGRRFSEAVEMACRSTQLVAVGVNCCPAPLVKPLLESAKSHKRADL 249 Query: 249 PLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 VVYPNSGE +D V+ W E A+ +W+A GA IGGCCR PADI LK Sbjct: 250 SWVVYPNSGEGWD-VTTGWKT--EMRTSFANLSLEWKAQGALWIGGCCRVRPADITELK 305 >UniRef50_Q5PNQ3 Novel protein containing a homocysteine S-methyltransferase domain (Fragment) n=4 Tax=Euteleostomi RepID=Q5PNQ3_DANRE Length = 318 Score = 215 bits (547), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 121/303 (39%), Positives = 179/303 (59%), Gaps = 15/303 (4%) Query: 17 LLLDGAMATELEARGCNL-ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 +LDG +ATELEA G L D LWSA+VL +P+ I++VH Y ++G+ TA+YQA+ Sbjct: 13 FILDGGLATELEASGFQLQGDPLWSARVLHTDPQAIKDVHYRYLQSGSDVITTATYQASI 72 Query: 76 AGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQAGTL--LVAGSVGPYGAYLADG 132 GF G+ +++ ++ +V+LA++ +++++P + LVAGSVGPYG++L DG Sbjct: 73 EGFVKYLGVQPEEAQHMMMSAVQLAKETVSEFISQSPMSDRREPLVAGSVGPYGSFLHDG 132 Query: 133 SEYRGDYH--CSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRAR 190 SEY G Y +VE + +HRP+++ L+ AGADL+A ET+P E EAL ++L +P + Sbjct: 133 SEYTGAYEDKMTVEELKDWHRPQIQCLVKAGADLVAMETIPGLKEAEALVKVLKEFPETK 192 Query: 191 AWFSFT----LRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQ--HLHG 244 AW SF+ +D+ +S G + V + Q+VA+G+NC L+ H Sbjct: 193 AWLSFSSINLFQDNNSISSGRRFSEAVEMACRSTQLVAVGVNCCPALLVKPLLESAKSHK 252 Query: 245 LTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 L VVYPNSGE +D V+ W E A+ +W+A GA IGGCCR PADI Sbjct: 253 RADLSWVVYPNSGEGWD-VTTGWKT--EMRTSFANLSLEWKAQGALWIGGCCRVRPADIT 309 Query: 305 ALK 307 LK Sbjct: 310 ELK 312 >UniRef50_Q5ZBZ6 Os01g0772900 protein n=3 Tax=Magnoliophyta RepID=Q5ZBZ6_ORYSJ Length = 328 Score = 215 bits (547), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 132/305 (43%), Positives = 173/305 (56%), Gaps = 44/305 (14%) Query: 18 LLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPAG 77 ++DG +ATELEA G +L D LWSA LV P LIR+VHLDY AGA +ASYQAT G Sbjct: 26 VVDGGLATELEAHGADLHDELWSASCLVSAPHLIRKVHLDYLDAGANIITSASYQATIQG 85 Query: 78 FAARGLDEAQSKALIGKSVELARKAREAYLAENPQAG-----------TLLVAGSVGPYG 126 F ARGL +S+AL+ +SV +A++AR A AE G +LVA S+G YG Sbjct: 86 FQARGLSRERSEALLRRSVHIAQEAR-AIFAEGWSKGPYANHRSSPRRPVLVAASIGSYG 144 Query: 127 AYLADGSEYRGDYHCSV--EAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 AYLADGSEY GDY SV E ++FHR R++ L DAG DL+A ET+PN E +A Sbjct: 145 AYLADGSEYTGDYGISVTKETLKSFHRRRLQVLADAGPDLIAFETIPNKLEAQA------ 198 Query: 185 AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHG 244 G P+ + A+ +V A+G+NC A + + Sbjct: 199 --------------------SGDPITECAAVADACARVGAVGVNCTAPRLVHGLILSIRK 238 Query: 245 LTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLP---QWQAAGARLIGGCCRTTPA 301 +T P+VVYPNSGE Y A +K W E A D++ +W+ AGA L+GGCCRT+PA Sbjct: 239 VTSKPVVVYPNSGETYVAETKEWVES-EGGASETDFVSCVGKWRQAGAALVGGCCRTSPA 297 Query: 302 DIAAL 306 + A+ Sbjct: 298 TVRAI 302 >UniRef50_UPI0000DB6B54 PREDICTED: similar to CG10621-PA n=3 Tax=Apocrita RepID=UPI0000DB6B54 Length = 320 Score = 210 bits (535), Expect = 5e-53, Method: Compositional matrix adjust. Identities = 116/313 (37%), Positives = 176/313 (56%), Gaps = 18/313 (5%) Query: 14 QDILLLDGAMATELEARGCNL--ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 Q++++LDG +T+L + D LW+A+ LV NP I HLD+ +AGA +T +Y Sbjct: 2 QEVMVLDGGFSTQLATHVDDTIDGDPLWTARFLVTNPNAIISTHLDFLKAGADIILTNTY 61 Query: 72 QATPAGFAA-RGLDEAQSKALIGKSVELARKAREAYLAENPQAGTL-----LVAGSVGPY 125 QA+ GF+ + E +S + K+V+ A++A Y + G + L+AGS+GPY Sbjct: 62 QASIDGFSKYMNITEEESLDIFSKAVDYAKEAVNLYKKDIENKGNVINANPLIAGSIGPY 121 Query: 126 GAYLADGSEYRGDYHCSV--EAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 GA L D SEY G Y +V E +HRPR++ L+D G +LA ET+P E EAL +LL Sbjct: 122 GACLHDASEYSGKYCSNVTEEFLINWHRPRIQKLIDNGVHILAIETIPCKQEAEALIKLL 181 Query: 184 TAYPRARAWFSFT-LRDSEHLSDGTPLRDVVALL---AGYPQVVALGINCIALENTTAAL 239 +P ++AW SF+ D + ++DGT + + A Q++A+G+NC A +N T L Sbjct: 182 KEFPNSKAWLSFSCCNDGKSIADGTNFQQIAMQCYREALPKQILAIGVNCTAPQNVTKLL 241 Query: 240 QHL---HGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCC 296 + + + +PLVVYPNSGE Y + W E L +++ +W G R IGGCC Sbjct: 242 KGINENNKQEFVPLVVYPNSGEKY-TIENGWTIKDEEECSLHEFIYEWLTLGVRYIGGCC 300 Query: 297 RTTPADIAALKAR 309 RT DI +++ Sbjct: 301 RTNATDIKKIRSE 313 >UniRef50_C3ZEE1 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae RepID=C3ZEE1_BRAFL Length = 315 Score = 210 bits (534), Expect = 6e-53, Method: Compositional matrix adjust. Identities = 120/303 (39%), Positives = 170/303 (56%), Gaps = 14/303 (4%) Query: 18 LLDGAMATELEARGCNLA-DSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 +LDG +ATEL+ G ++ D LWSA++L NP I++VH + AG+ ITA+YQA+ Sbjct: 5 VLDGGLATELDFAGFDINNDPLWSARLLATNPAAIKQVHKSFLSAGSDVIITATYQASVP 64 Query: 77 GFAAR-GLDEAQSKALIGKSVELARKA-----REAYLAENPQAGTLLVAGSVGPYGAYLA 130 GF G+ ++ L+ V +A++A +E + P L AGSVGPYGA L Sbjct: 65 GFQEYLGVSVEEAHKLMDHGVRIAKQACLEFCKEQDKGDFPGRRNPLAAGSVGPYGACLH 124 Query: 131 DGSEYRGDY--HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPR 188 D SEY G+Y S+E Q +HRPR+ L+ +GAD++A ET+P E AL +LL +P Sbjct: 125 DASEYTGEYVDSMSIEELQRWHRPRLGQLITSGADMVAIETIPAVKEAAALVQLLREFPN 184 Query: 189 ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVL 248 RAW +F+ +D H G + +A + PQV A G NC E+ LQ L Sbjct: 185 TRAWVTFSCKDGLHTCHGESFPEAIAAVLKSPQVFAAGANCCMPEHVAPLLQKARELCKD 244 Query: 249 P---LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAA 305 P + YPNSGE + A WH + C L+ ++P+W GAR IGGCCRT P DI Sbjct: 245 PAKFFIAYPNSGEKW-AAGTGWHGKAD-CRPLSTFVPEWLDHGARWIGGCCRTRPDDIKD 302 Query: 306 LKA 308 +++ Sbjct: 303 IRS 305 >UniRef50_B3S7K9 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3S7K9_TRIAD Length = 321 Score = 210 bits (534), Expect = 6e-53, Method: Compositional matrix adjust. Identities = 120/311 (38%), Positives = 177/311 (56%), Gaps = 16/311 (5%) Query: 11 LDKQDILLLDGAMATELEARGCNL-ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITA 69 +DK+ IL++DGA TEL+ G ++ AD LWSA +L+ NP++I+++H Y AGA +TA Sbjct: 1 MDKE-ILVIDGACGTELQRLGYDVDADPLWSASLLLTNPQVIKDLHTSYLNAGADIILTA 59 Query: 70 SYQATPAGFAARG-LDEAQSKALIGKSVELARKAREAYLAE------NPQAGTLLVAGSV 122 +YQA+ G L EA + A+I +V LA +AR+ + AE N + LV GSV Sbjct: 60 TYQASIPGLVQYADLTEASASAVIAMAVRLAIEARDEFWAEQKACNKNVRRPKPLVVGSV 119 Query: 123 GPYGAYLADGSEYRGDY--HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 GP+GA DGSE+ G Y ++E + +H+PR+ L+ G DL+A ET+P E AL Sbjct: 120 GPFGACQHDGSEFHGRYTDEMTIEELKQWHKPRIMELIQNGVDLIAFETIPAEKEAIALI 179 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQ 240 ++L + +AW SF +D HL+ G DV+ + Q+VA+G NC +N +Q Sbjct: 180 QVLETFRGVKAWLSFVCKDDLHLNHGELFADVMERFRNHNQIVAIGTNCTNPQNVDNLIQ 239 Query: 241 HLHGLTVL--PLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRT 298 L P + YPNSGE + W +L+DY+ +W G R IGGCCRT Sbjct: 240 SCKRLDAYDKPFIAYPNSGESWSV--DRWDPTIPP-VELSDYVQRWIKNGIRWIGGCCRT 296 Query: 299 TPADIAALKAR 309 TP+DI ++ + Sbjct: 297 TPSDILKIRNK 307 >UniRef50_Q4S116 Chromosome 1 SCAF14770, whole genome shotgun sequence n=5 Tax=Euteleostomi RepID=Q4S116_TETNG Length = 372 Score = 208 bits (530), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 129/323 (39%), Positives = 179/323 (55%), Gaps = 33/323 (10%) Query: 17 LLLDGAMATELEARGCNL-ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 +LDG +AT+LEA+G +L D LWSA++L NP+ IR+ H + +GA TA+YQA+ Sbjct: 17 FILDGGLATDLEAQGVHLQGDPLWSARLLYTNPQAIRDAHCRFLLSGADVISTATYQASV 76 Query: 76 AGFAAR-GLDEAQSKALIGKSVELARKAREAYL-AENP----QAG--------------- 114 GF + +K LI V+LA++A E+++ NP Q+G Sbjct: 77 EGFMDHLNVSSEGAKELIMSGVQLAKEAVESFVPGTNPNTTVQSGEGKVNSEGSEGLAGQ 136 Query: 115 ------TLLVAGSVGPYGAYLADGSEYRGDY--HCSVEAFQAFHRPRVEALLDAGADLLA 166 LVAGS+GPYGA+L +GSEY GDY SV+ +A+HRP+VE L A AD+LA Sbjct: 137 CSSGRRCPLVAGSLGPYGAFLHNGSEYTGDYAEKMSVQELKAWHRPQVECLAAAEADVLA 196 Query: 167 CETLPNFSEIEALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALG 226 ET+P+ E EAL ELL +P +AW S + +D + LSDG+ RD V + Q++A+G Sbjct: 197 FETIPSIKEAEALVELLKEFPNTKAWLSLSCKDVKRLSDGSLFRDAVQIANRSEQLIAVG 256 Query: 227 INCIALENTTAALQHLHGLTV--LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW 284 +NC E L L + VVYPNSGE +D + W L + W Sbjct: 257 VNCCPPELVEPLLDSARTLLSPEISWVVYPNSGESWDP-EQGWCTSEAALPALLEMSGTW 315 Query: 285 QAAGARLIGGCCRTTPADIAALK 307 GA LIGGCCR +PA +A L+ Sbjct: 316 VKQGAALIGGCCRISPAHVAKLR 338 >UniRef50_Q49V93 Putative homocysteine S-methyltransferase n=1 Tax=Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 RepID=Q49V93_STAS1 Length = 301 Score = 204 bits (520), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 110/301 (36%), Positives = 162/301 (53%), Gaps = 16/301 (5%) Query: 11 LDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITAS 70 L Q L+LDG +AT LE GC+L SLWS++VL NP I++ H + GA +T++ Sbjct: 7 LKAQSPLVLDGGLATTLEQAGCSLKTSLWSSEVLKNNPTQIKQAHQAFTDVGADILLTST 66 Query: 71 YQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLA 130 YQA+ F+ G+ + L +V +A T ++ GS+GPYGAYL+ Sbjct: 67 YQASYQTFSDIGMKATEIDQLYNTAVNQIMEAT---------TDTQVIVGSLGPYGAYLS 117 Query: 131 DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA-YPRA 189 DGSEY G Y S E + FH+ R+EAL+ G + ET+PNF EI+A+ E + Y Sbjct: 118 DGSEYTGAYDLSKEDYFQFHKTRIEALVKRGINDFVFETVPNFEEIKAIVEYIVPHYTNQ 177 Query: 190 RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVV-ALGINCIALENTTAALQHLHGLTVL 248 W S T+ + LSD T + A + Y + + GINC ++ A+ GL + Sbjct: 178 TFWLSVTVNEDGDLSDDTEFEKLCAYIKQYAERIPVFGINCSSVAGINKAIS--KGLKNV 235 Query: 249 P--LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 P + +YPN G Y+AV K W G + + +P W G ++IGGCC+TTP +I ++ Sbjct: 236 PQTIALYPNGGAQYNAVEKEWESVGNQ-GLIVEQIPGWLDQGVKIIGGCCQTTPENIKSI 294 Query: 307 K 307 K Sbjct: 295 K 295 >UniRef50_Q9VJ32 CG10621 n=19 Tax=Neoptera RepID=Q9VJ32_DROME Length = 331 Score = 197 bits (501), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 124/311 (39%), Positives = 171/311 (54%), Gaps = 25/311 (8%) Query: 16 ILLLDGAMATELEARGCNLADS--LWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 +L+ DG T++ + D LWSA+ NP I HLD+ + GA +T +YQ+ Sbjct: 6 VLVKDGGFGTQMTVHVGDSVDGDPLWSARFNATNPAAIISTHLDFLQNGADIILTNTYQS 65 Query: 74 TPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQA------GTLLVAGSVGPYG 126 + G+ LDE QS LI +V LA A+E YL E QA G L+ S+GP+G Sbjct: 66 SVDGYMEYLELDEEQSIELIKNTVRLAHIAKERYLTECYQAQLSVQEGYPLIIASIGPFG 125 Query: 127 AYLADGSEYRGDYHCSVEAFQA--FHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 A+L DGSEY G Y V A + +HR R+EA L+AG D LA ET+P E EAL E+L Sbjct: 126 AHLHDGSEYTGSYADFVPAKEITDWHRVRIEACLEAGVDALAIETIPCQMEAEALVEMLC 185 Query: 185 A-YPRARAWFSFTLRDSEHLSDG-------TPLRDVVALLAGYPQVVALGINCIALENTT 236 YP + W +F +D L+ G + D++A + +A+G+NC+ + T Sbjct: 186 DDYPDVKFWVAFQCKDENTLAHGETFADAANAIWDLLAERNAQDKCLAIGVNCVHPKFVT 245 Query: 237 AALQHLHGL----TVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLI 292 + L+G +PLVVYPNSGE YD V+ W EHC LA+Y+P+W GA++I Sbjct: 246 PLFKSLNGDREVGEQIPLVVYPNSGEVYDVVNG-WQGR-EHCVPLANYVPEWAQLGAKVI 303 Query: 293 GGCCRTTPADI 303 GGCCRT DI Sbjct: 304 GGCCRTYARDI 314 >UniRef50_A0APQ1 CG10623 protein n=22 Tax=Drosophila RepID=A0APQ1_DROME Length = 331 Score = 194 bits (494), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 114/315 (36%), Positives = 171/315 (54%), Gaps = 22/315 (6%) Query: 12 DKQDILLLDGAMATELEARGCNLADS--LWSAKVLVENPELIREVHLDYYRAGAQCAITA 69 D + IL+ G +++L D LW ++ NPE + + HLD+ R GA +T Sbjct: 10 DTKPILVKCGGFSSQLAKNVTEKVDGDPLWGSRFDATNPEAVIQTHLDFLRNGADIILTN 69 Query: 70 SYQATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAE---NPQAGTLLVAGSVGPY 125 +YQ++ GF G+ + LI KSV+LA++A+E YL+E ++ L+ GS+GPY Sbjct: 70 TYQSSVEGFVKYLGVTRERGVELIQKSVQLAKQAKEQYLSEIGSEAESALPLIMGSIGPY 129 Query: 126 GAYLADGSEYRGDY--HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL- 182 GAYL DGSEY G+Y S E +A+H+ R+E L AG D LA ETLP E EA+ EL Sbjct: 130 GAYLHDGSEYTGNYADKLSKEELRAWHKTRIEICLAAGVDGLALETLPCLMEAEAVTELV 189 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGT-------PLRDVVALLAGYPQVVALGINCIALENT 235 L +P A+ W S D +H++ G L +V +++ +G+NC+ Sbjct: 190 LDNFPDAKFWVSLQCMDEKHMASGENFAEAALSLWRLVQSRKAENRLLGIGLNCVNPLFV 249 Query: 236 T---AALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLI 292 T ++L + G +PLVVY N GE YD W GE ++ ++P+W G R++ Sbjct: 250 TPLLSSLTKVAGSDRIPLVVYSNRGEIYDVEQGDWTGTGE---EVVKFVPEWIQLGVRIV 306 Query: 293 GGCCRTTPADIAALK 307 GGCCR P D+ A++ Sbjct: 307 GGCCRVYPTDVLAIR 321 >UniRef50_Q2F5Q8 Homocysteine S-methyltransferase n=3 Tax=Endopterygota RepID=Q2F5Q8_BOMMO Length = 325 Score = 193 bits (491), Expect = 5e-48, Method: Compositional matrix adjust. Identities = 113/310 (36%), Positives = 170/310 (54%), Gaps = 15/310 (4%) Query: 14 QDILLLDGAMATELEARGCNLADS--LWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 + + +LDG +T+L + AD L SA+ L +P+ + HLD+ RAG+ T +Y Sbjct: 9 KTVFVLDGGFSTQLTCHAGHTADGDPLGSARFLKTHPQDVINTHLDFLRAGSDIIETNTY 68 Query: 72 QATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAE----NPQAGTLLVAGSVGPYG 126 QA+ G L +S LI +VE AR AR+ YL E N L+AGSVGPYG Sbjct: 69 QASVDGLVKHLNLTVEESYELIKSAVEFARTARDLYLQECQESNLSGRKPLIAGSVGPYG 128 Query: 127 AYLADGSEYRGDY--HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 AYL D SEY G+Y + + E + +HR R++AL++AG D+LA ET+P E EAL E+L Sbjct: 129 AYLHDTSEYTGNYADNTTKETIKNWHRTRIQALVEAGVDILAFETIPCQKEAEALVEILK 188 Query: 185 AYPRARAWFSFTLRDSEHLSDGTPLRDVVALL--AGYPQVVALGINCIALENTTAALQHL 242 YP +AW SF+ ++ L+ G ++V + Q++A+G+N + + T + + Sbjct: 189 EYPNMKAWLSFSCKNETSLAHGENFQNVAKKCWKSNPDQLIAIGVNGCSPKIVTELFKDI 248 Query: 243 HG--LTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 + T + + YPNSGE YD K + C L + + +W G R IGGCCRT Sbjct: 249 NNDQETSIQYITYPNSGETYD--HKLGWTESDKCESLHNLVAEWLDLGVRYIGGCCRTND 306 Query: 301 ADIAALKARS 310 DI+ ++ + Sbjct: 307 VDISRIRIET 316 >UniRef50_C4R8J7 S-adenosylmethionine-homocysteine methyltransferase n=1 Tax=Pichia pastoris GS115 RepID=C4R8J7_PICPG Length = 321 Score = 184 bits (467), Expect = 4e-45, Method: Compositional matrix adjust. Identities = 109/319 (34%), Positives = 168/319 (52%), Gaps = 20/319 (6%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M+ + + L ++ +LDGA+ TELE G ++ LWS K L +PE I ++H Y + Sbjct: 1 MTPITKMDSWLKQKRCRVLDGALGTELEKLGIDIKSRLWSGKALFYSPETITQIHSSYIQ 60 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGA+ +T +YQ + G G+D+ + ++V+LA+ A + EN + G Sbjct: 61 AGAELILTCTYQLSDQGLKDLGIDDPD---VYDRAVKLAKDAVDQNEGENKAK----IVG 113 Query: 121 SVGPYGAYLADGSEYRGDYH-CSVEAFQAFHRPRVEALL-DAGADLLACETLPNFSEIEA 178 S+G YGAYL+ G EY G+Y S + FHR R+++LL + DL+ ET+PN E E Sbjct: 114 SIGSYGAYLSGGEEYTGEYGAISKSELEEFHRVRLQSLLTNPDVDLIGFETIPNILEAET 173 Query: 179 LAELLTAYPRARA-----WFSFTLRDSEH---LSDGTPLRDVVALLA--GYPQVVALGIN 228 L L A + + SF R+ + ++DGT + +V L+ ++ A+G N Sbjct: 174 LVVLFNALATSLNVDKGYYMSFNCREESNQSVIADGTSIPEVSDRLSKLDVSRMYAIGTN 233 Query: 229 CIALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG 288 C ++ A++ T LPL+VYPNSGE YD K W GE ++ D + W Sbjct: 234 CCSISTANGAVELFSKHTNLPLIVYPNSGERYDKTEKKW-LPGECDQKITDIVVNWLQLN 292 Query: 289 ARLIGGCCRTTPADIAALK 307 ++IGGCCRT P I L+ Sbjct: 293 VKIIGGCCRTNPHFIRQLR 311 >UniRef50_A3TGH3 Homocysteine methyltransferase n=1 Tax=Janibacter sp. HTCC2649 RepID=A3TGH3_9MICO Length = 305 Score = 183 bits (464), Expect = 8e-45, Method: Compositional matrix adjust. Identities = 116/282 (41%), Positives = 159/282 (56%), Gaps = 17/282 (6%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 ++LDG +T LEARG +L+ LWSA++L + P + H + AGA+ I+ASYQA+ A Sbjct: 23 VVLDGGFSTALEARGHDLSGRLWSARLLRQAPSEVVAAHRTFVDAGAEIVISASYQASHA 82 Query: 77 GFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYR 136 G+ A GL E + A + S+ELAR+ + G LVA SVGPYGA+LADGSEY Sbjct: 83 GYVAAGLTEEECDADLDASIELARQGAD---------GRALVAASVGPYGAHLADGSEYT 133 Query: 137 GDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY-PRARAWFSF 195 G S + FH R+E L+ AG DL+A ET+P +E E + ELLT P W SF Sbjct: 134 GYPAVSRATLREFHSRRLERLIAAGPDLVAVETIPEVAEAEVVVELLTEIAPDLPYWVSF 193 Query: 196 TLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYPN 255 + L+ G P + + ++ G +A+G+NC A + L+ G +P V+YPN Sbjct: 194 SATGGGRLTGGAPFAEAIGVVRG--AAIAVGVNCTAPRHIDELLE--AGGPNVPYVIYPN 249 Query: 256 SGEHYDAVSKTWHHHGE-HCAQLADYLPQWQAAGARLIGGCC 296 +G YD SKTW G H A + +W GAR IGGCC Sbjct: 250 AGATYDPGSKTWTEDGSAHFAPTT--VQRWNDLGARFIGGCC 289 >UniRef50_D0NSW2 Homocysteine S-methyltransferase, putative n=1 Tax=Phytophthora infestans T30-4 RepID=D0NSW2_PHYIN Length = 332 Score = 179 bits (453), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 121/313 (38%), Positives = 174/313 (55%), Gaps = 17/313 (5%) Query: 10 LLDKQDILLLDGAMATELEA--RGCNLADSLWSAKVLVENPELIREV----HLDYYRAGA 63 L DK +++LDG ATELE R A SLWS +L++ + +++V H +Y+ AGA Sbjct: 13 LADKSRVVVLDGGFATELEKDPRVDLSASSLWSGSLLLDQNQHLQDVVVNAHTNYFLAGA 72 Query: 64 QCAITASYQATPAGFAARGLDEAQS-KALIGKSVELARKAREAYLAENPQAGTL--LVAG 120 A T SYQA+ GF G+ + + L KS++L +AR+A E Q+ + LV Sbjct: 73 DVATTVSYQASVDGFKREGVTALEDVEKLFAKSIDLGAQARDAAWNELQQSKRIKPLVGA 132 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLD-AGADLLACETLPNFSEIEAL 179 S+G YGA LADGSEYRGDY + A+H+ R A A+ L CET+P E+EA Sbjct: 133 SIGCYGAALADGSEYRGDYGKTKNELVAWHKHRFAFFTSYAPANFLICETIPCLVEVEAF 192 Query: 180 AELLTAYPRARAWFSFTLRDSEHLSDGTPLR---DVVALLAGYPQVVALGINCIALENTT 236 +LL +P A A + + + L+ G P+ +++A L Q++A+GINC + Sbjct: 193 VDLLNEFPTAHAIVAVACHNGKELNSGEPIARIPEILAKLNNPSQLLAIGINCTPPQYVE 252 Query: 237 AALQHLHGLTVLPLVVYPNSGEHYDAVSKTW--HHHGEHCAQLADYLPQWQAAGARLIGG 294 + L L P VYPNSGE +D V+K W + + +YLP+W AGAR GG Sbjct: 253 SLLLELD--CPWPKAVYPNSGEGWDGVNKKWLPADNTGGPSSWEEYLPKWYDAGARFFGG 310 Query: 295 CCRTTPADIAALK 307 CCRT+P DI A++ Sbjct: 311 CCRTSPDDIRAIR 323 >UniRef50_B9W8L8 Homocysteine S-methyltransferase, putative (S-methylmethionine:homocysteine methyltransferase, putative) n=3 Tax=Candida RepID=B9W8L8_CANDC Length = 311 Score = 177 bits (449), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 108/308 (35%), Positives = 162/308 (52%), Gaps = 20/308 (6%) Query: 7 LRALLDKQDILLLDGAMATELE----ARGCNLADS--LWSAKVLVENPELIREVHLDYYR 60 ++ LL+K+ L++DGA+ TELE L S LWS +VL++NPEL+ +VHLDY Sbjct: 4 VKDLLEKKK-LVIDGALGTELERLLPTTSTYLPSSSPLWSGQVLIKNPELVEQVHLDYIN 62 Query: 61 AGAQCAITASYQATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVA 119 AGA IT++YQ + A G D Q+ L ++++A+ A + +++A Sbjct: 63 AGADMIITSTYQTSYASLHKYIGYDMDQAVTLWNSALDVAKSA-----VKKSGRDDVIIA 117 Query: 120 GSVGPYGAYLADGSEYRGDYH-CSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 GS+GPY LA+GSEY GDY S + +H P E ++ D++ ET+P+F E++ Sbjct: 118 GSIGPYATLLANGSEYNGDYQGVSDQELIEYHTPLFEFYNNSDVDIICIETIPSFQELKV 177 Query: 179 LAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLA--GYPQVVALGINCIALENTT 236 + L Y + S + LSDGT L +V L A P+ VA+GINC + EN Sbjct: 178 IIGLTKKYTSKEFFISINPQTGSALSDGTSLTEVAQLFAEINDPRFVAVGINCTSYENVD 237 Query: 237 AALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW-QAAGARLIGGC 295 + LT P+ +YPN G YD + + A+ + +W + IGGC Sbjct: 238 QISTY---LTNFPIFIYPNLGFVYDTTVHKFVSKMLQESAWANSIAKWLNLPNVKAIGGC 294 Query: 296 CRTTPADI 303 C TTPA+I Sbjct: 295 CSTTPAEI 302 >UniRef50_UPI000180BE5F PREDICTED: similar to CG10623 CG10623-PA n=1 Tax=Ciona intestinalis RepID=UPI000180BE5F Length = 305 Score = 174 bits (440), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 109/315 (34%), Positives = 159/315 (50%), Gaps = 43/315 (13%) Query: 14 QDILLLDGAMATELEARGCNL-----ADSLWSAKVLVENPELIREVHLDYYRAGAQCAIT 68 +DI +LDG + T+L G + D LWSA+VL E PE I + HL + +AG+ T Sbjct: 2 EDIKILDGGLCTDLFINGGFVRAEVNKDPLWSARVLYEKPEEIMKAHLRFIKAGSDVVST 61 Query: 69 ASYQATPAGFAARG-LDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGA 127 SYQA+ G+ + + +++ +IG SV++A++A + +LVAGS+ PYGA Sbjct: 62 CSYQASVQGYMEHAQVTKEKAEKIIGSSVDVAKQAVQ------ESGRRVLVAGSISPYGA 115 Query: 128 YLADGSEYRGDY--HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA 185 L D SEY G Y S + FH+ + L G DL A ETLP+ E LAE+L Sbjct: 116 ILHDMSEYTGSYIDTTSEQQLSDFHKTNIRILASKGVDLFAFETLPSLKEALVLAEILRE 175 Query: 186 YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL 245 YP +AW SF+ ++ H G P +V L Y Q++A+G+NC E ++ +Q HG Sbjct: 176 YPTLKAWVSFSNKNGTHTCYGEPFEEVFKALGNYHQIIAIGLNCCKSETISSFIQLAHGN 235 Query: 246 TVL--PLVVYPNS--GEHYDAVS---------KTWHHHGEHCAQLADYLPQWQAAGARLI 292 L++YPN+ G + ++ KTW L L W I Sbjct: 236 LAKHQRLIIYPNNCAGGNVNSSEAPLEWLPKVKTW---------LESNLIGW-------I 279 Query: 293 GGCCRTTPADIAALK 307 GGCC T+P I +K Sbjct: 280 GGCCMTSPFQIGQIK 294 >UniRef50_C3PEG0 Homocysteine S-methyltransferase n=3 Tax=Corynebacterium RepID=C3PEG0_CORA7 Length = 292 Score = 173 bits (439), Expect = 7e-42, Method: Compositional matrix adjust. Identities = 114/291 (39%), Positives = 160/291 (54%), Gaps = 10/291 (3%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 LLLDG + T LEA+G +++ LWSA+VL ENP L+ H D++ AGAQ A TASYQ T Sbjct: 8 LLLDGGLGTHLEAQGHDISGPLWSARVLRENPTLLESAHADFFAAGAQVATTASYQVT-- 65 Query: 77 GFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYR 136 F G D ++AL+ +SV +AR+A + ++ G LLVA S+GPYGA G++Y Sbjct: 66 -FDVLGED---AEALLRRSVAVAREAVRVAVDKHTAHGDLLVAASIGPYGAGPGKGTDYD 121 Query: 137 GDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSFT 196 G Y Q +H R+ L D AD L ET+PN E AL ELL A P+ F+ + Sbjct: 122 GAYDLRRGELQRWHARRIAVLADTDADFLLAETIPNVDEAAALLELLKAQPKP---FALS 178 Query: 197 LRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYPNS 256 + + +D L V+ L ++ ALG+NC++ A + L T PL+ PNS Sbjct: 179 ITGA-IAADQAKLSQVIELANQSSRLGALGVNCVSPSQARAVVATLRAGTDKPLLACPNS 237 Query: 257 GEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 GE +D + W L + Q +AAG ++GGCCR PA+I L+ Sbjct: 238 GEVWDCTAHDWQPAPADAMSLPEAALQLRAAGVSVLGGCCRVGPAEIRQLR 288 >UniRef50_C4XYV2 Putative uncharacterized protein n=1 Tax=Clavispora lusitaniae ATCC 42720 RepID=C4XYV2_CLAL4 Length = 329 Score = 167 bits (423), Expect = 4e-40, Method: Compositional matrix adjust. Identities = 112/323 (34%), Positives = 171/323 (52%), Gaps = 37/323 (11%) Query: 13 KQDILLLDGAMATELEARGCNLADS-------LWSAKVLVENPELIREVHLDYYRAGAQC 65 K+ +L+ DGA+ T+LEA L D LWS L+ +PELI +H Y AGA Sbjct: 8 KKSVLVQDGALGTQLEAL-IPLDDPHSVKGSPLWSTNALLYSPELISSIHKQYVEAGADM 66 Query: 66 AITASYQATPAGFAA-RGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP 124 ITA+YQA+P + +D AQ+K + KSVE A +A + P+ + + GS+GP Sbjct: 67 IITATYQASPQTLSKYENMDLAQAKKVWTKSVECALEATRTH----PEK-KIFIGGSIGP 121 Query: 125 YGAYLADGSEYRGDY-HCSVEAFQAFHRPRVEALLDAG-ADLLACETLPNFSEIEA---- 178 YGAYLA+G+EY GDY S + +HR V + D++A ET+PNF+E++A Sbjct: 122 YGAYLANGAEYSGDYGDISSDQLMDYHRDIVRFYAETKEVDVIAFETVPNFAEVQAIFSL 181 Query: 179 LAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYP------QVVALGINCIAL 232 + ++ A + S + +D++HL DGTPL V+ + +V +G NC+ Sbjct: 182 IEQMFNANLHKEFYVSLSCKDADHLVDGTPLEQVIRYILSKKSSQISDNLVGIGCNCVPF 241 Query: 233 ENTTAALQHL------HGLTVLPLVVYPNSG-EHYDAVSKTWHHHGEHCAQLADYLPQWQ 285 E + ++ + +G L L+VYPN G E D + + E + A + +W Sbjct: 242 EIVSDFIETVNRVCQNNGSEQLSLLVYPNLGFEPTDTANYAFRSSTE---KWASSVAKWA 298 Query: 286 A-AGARLIGGCCRTTPADIAALK 307 + R+IGGCC T PA+IA +K Sbjct: 299 LYSNVRVIGGCCSTGPAEIAQIK 321 >UniRef50_C5MAR2 Putative uncharacterized protein n=1 Tax=Candida tropicalis MYA-3404 RepID=C5MAR2_CANTT Length = 312 Score = 162 bits (410), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 96/308 (31%), Positives = 158/308 (51%), Gaps = 24/308 (7%) Query: 13 KQDILLLDGAMATELE------ARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 +Q L++DGA+ TELE + LWS + L+ NPEL+ +VHLDY AGA Sbjct: 9 QQKKLVIDGALGTELERLLPSSSASLPSNSPLWSGQALINNPELVEQVHLDYINAGADII 68 Query: 67 ITASYQATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQAG--TLLVAGSVG 123 IT++YQ + A G D + KSVEL A A ++G +++AGS+G Sbjct: 69 ITSTYQTSYASLNKYAGYD-------MKKSVELWNSALGAAKNAVNRSGRSDVIIAGSIG 121 Query: 124 PYGAYLADGSEYRGDYH-CSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 PY LA+GSEY GDY + + +H P E ++ D++ ET+PNF+E++ + ++ Sbjct: 122 PYATVLANGSEYSGDYQGATYDDLVEYHTPLFEFYDNSDVDVICIETIPNFTELKVVIDM 181 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLR---DVVALLAGYPQVVALGINCIALENTTAAL 239 + Y + + + + + LSDGT L +V + + + +GINC + L Sbjct: 182 MKKYTKKEYFIAVNPQTANALSDGTTLDKVAEVFKTIEDTSRFLGVGINCTNYDLVNDIL 241 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW-QAAGARLIGGCCRT 298 ++ T P+++YPN G YD + + H + + +W + R +GGCC T Sbjct: 242 KY---FTDFPVLIYPNMGFVYDTETHKFVPEANHELSWENAVKKWLNSDNVRAVGGCCST 298 Query: 299 TPADIAAL 306 P++I+ + Sbjct: 299 GPSEISIV 306 >UniRef50_Q6BZK6 DEHA2A00616p n=1 Tax=Debaryomyces hansenii RepID=Q6BZK6_DEBHA Length = 351 Score = 162 bits (409), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 106/341 (31%), Positives = 167/341 (48%), Gaps = 40/341 (11%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLADS---------LWSAKVLVENPELIREVH 55 N + L++ + L++DGA+ T+LE + L LWSA VL++NPELI+EVH Sbjct: 3 NDINTLINTKP-LVIDGALGTQLETKFSKLLQQDNINIQTHPLWSALVLLKNPELIQEVH 61 Query: 56 LDYYRAGAQCAITASYQATPAGFA--ARGL-DEAQSKALIGKSVELARKAREAYLAENPQ 112 DY +GA T++YQA+ G A G+ ++ + A+ K++ELA AR YL EN Sbjct: 62 YDYMCSGANIITTSTYQASKRGLLEYAPGIENDDEVNAVYDKAIELAVDARSQYL-ENMG 120 Query: 113 AGT-------LLVAGSVGPYGAYLADGSEYRGDYHCSV---EAFQAFHRPRVEALL-DAG 161 G + + GS+GP+GAYLA+G+EY G Y + + + FH + + Sbjct: 121 KGMNTLTNKEIFICGSIGPFGAYLANGAEYTGKYGSHITEPQELKKFHYDITSQFISNPK 180 Query: 162 ADLLACETLPNFSEIEALAEL---LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAG 218 D++ ET+PN+SE + + L L + S +D + + DGTP+ VV L Sbjct: 181 CDIIGFETIPNYSEFQQIVHLMEELLQKTNKPFYISLNFKDPKTICDGTPITQVVDYLNE 240 Query: 219 --------YPQVVALGINCIALE---NTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTW 267 + LG NC+ LE N + L+ + PL+ YPN+G +YD + Sbjct: 241 RLSNNEKLRSAFIGLGCNCVPLEIATNILLNMSDLNNVHRFPLIAYPNAGLNYDLSKGEY 300 Query: 268 HHHGEHCAQLADYLPQW-QAAGARLIGGCCRTTPADIAALK 307 D +W + RL+G CC + P +I ++ Sbjct: 301 SIKSSEKQVWEDSCREWLEKLNVRLVGACCGSGPDEILTIR 341 >UniRef50_Q6C0D6 YALI0F25641p n=1 Tax=Yarrowia lipolytica RepID=Q6C0D6_YARLI Length = 348 Score = 161 bits (408), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 115/347 (33%), Positives = 169/347 (48%), Gaps = 58/347 (16%) Query: 16 ILLLDGAMATELEARGCNLAD----SLWSAKVLV-------------------------- 45 +L+LDG M TELE RG + +D +LWSAK L+ Sbjct: 1 MLILDGGMGTELENRGIDCSDPLWLTLWSAKFLLPINSDFLKCIESADPWTVDQLEKVNR 60 Query: 46 -------------ENPELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKAL- 91 +N L+ +H DY AGA +ASYQA+ G G + +AL Sbjct: 61 ALDEHPEWLESSQDNSNLLYRIHKDYVVAGADIVTSASYQASLEGTIKAGAVQRWPEALW 120 Query: 92 -IGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYRGDYHC-SVEAFQAF 149 + KS +L RKA + E +L+A SVGP+GA+L G EY GDY + + + Sbjct: 121 MLRKSEQLVRKA----VTEAKVKRKVLLAASVGPFGAWLGGGQEYNGDYTGYTKDDIRRH 176 Query: 150 HRPRVEALLDAGADLLACETLPNFSEIEALAELL-TAYPRAR--AWFSFTLRDSEH---- 202 H ++ A+L D+L ET+P+ E+E L ++L T P + S +++ +++ Sbjct: 177 HEFKIRAVLGGSPDMLLIETIPSIIEVEVLVDVLNTILPPSPIPVCLSLSVKSADYDRVA 236 Query: 203 LSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYPNSGEHYDA 262 L+DG+ L ++ L A P LG+NC A +L L T L L+VYPNSGE YD Sbjct: 237 LADGSELSNIAELAASCPSFTHLGVNCCAETVAKLSLDILQQHTSLQLIVYPNSGEVYDG 296 Query: 263 VSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKAR 309 +KTW + + A L WQ + ++GGCCRT P IA L+ + Sbjct: 297 ATKTWSGNCDSSFLEAATLSDWQTS-VSILGGCCRTGPPHIAFLRHK 342 >UniRef50_D2S8U0 Homocysteine S-methyltransferase n=12 Tax=Actinomycetales RepID=D2S8U0_9ACTO Length = 314 Score = 159 bits (403), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 126/298 (42%), Positives = 173/298 (58%), Gaps = 29/298 (9%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 ++LDG +AT+LEA+G +L+ LWS+++L + PE + H + AGAQ A TASYQ + Sbjct: 15 VVLDGGLATQLEAQGHDLSSELWSSRLLHDAPEAVVAAHAAFAAAGAQVATTASYQVSVE 74 Query: 77 GFAARGLDEAQSKALIGKSVELA-RKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 G AA GLD +++ L+ +SV LA R A +A+ +AGSVGPYGA LADGSEY Sbjct: 75 GLAAAGLDATEARRLVVRSVHLAERGAPDAW-----------IAGSVGPYGAALADGSEY 123 Query: 136 RGDY--HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL--LTAYPRARA 191 G Y V+ + +HRPR+E L +AGAD+LACET+P +E EAL E + P Sbjct: 124 TGAYADEIGVDRLRQWHRPRMEWLAEAGADVLACETVPAAAEAEALLEEADMLGMP---V 180 Query: 192 WFSF-TLRDSEHL---SDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTV 247 W S T+ DS+ + G P +V A+ VVA+G+NC + AA+ + Sbjct: 181 WLSLTTVLDSDGVVRTRRGEPAGEVFAMARDLDAVVAVGVNCTDPDGVLAAVTAAG-VAG 239 Query: 248 LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLP-QWQAAGARLIGGCCRTTPADIA 304 P+VVYPNSGE +DA + W A L+ + W AGARL+GGCCR P I Sbjct: 240 RPVVVYPNSGERWDAAGRRW----TGTAGLSPHNALTWVHAGARLVGGCCRVGPRSIG 293 >UniRef50_A8Q150 Probable homocysteine S-methyltransferase, putative n=1 Tax=Brugia malayi RepID=A8Q150_BRUMA Length = 315 Score = 158 bits (400), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 99/299 (33%), Positives = 154/299 (51%), Gaps = 11/299 (3%) Query: 14 QDILLLDGAMATELEARGCNLAD-SLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 + I +LDG TELEA G N+ + SLWS L +NP+LI +VH + AG+ +T SYQ Sbjct: 8 EKIQILDGGFGTELEAVGYNIENNSLWSCAALFDNPDLILQVHKRFIEAGSDIILTNSYQ 67 Query: 73 A-TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLAD 131 A ++ G+ + +++ + K V LA +A + E + + GSVGPYG D Sbjct: 68 ACINTMMSSHGMTKNAAESSLKKLVSLAEQA----INECSVREKVKIVGSVGPYGVIFND 123 Query: 132 GSEYRGDYHCSVE--AFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRA 189 GSEY G Y +E +H + LL AG ++A ET+P++ E A+ + A + Sbjct: 124 GSEYNGYYVDEIEQQVLVDYHMQQTIPLLQAGLKVIAYETVPSYKEALAILKAADAIGYS 183 Query: 190 -RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLH-GLTV 247 W SF+ ++ + + V +A +P ++ +GINC + T LQ + Sbjct: 184 YNFWISFSCKNDKQTNHNEDFCKSVEKIAHHPSILGIGINCTSPNYITPLLQSASTSVNS 243 Query: 248 LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 LP +VYPNSGE Y+ +K W G+ + L +W+ G +++GGCCR I L Sbjct: 244 LPFIVYPNSGEVYEHSTKKW-RIGKCRFPDIEQLIEWKDLGVKVVGGCCRVGAEKIKEL 301 >UniRef50_A3LQC9 AdoMet-homocysteine methyltransferase n=1 Tax=Pichia stipitis RepID=A3LQC9_PICST Length = 337 Score = 154 bits (389), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 103/324 (31%), Positives = 164/324 (50%), Gaps = 37/324 (11%) Query: 17 LLLDGAMATELEARGCNLADS--------LWSAKVLVENPELIREVHLDYY-RAGAQCAI 67 L+LDGAM TELEA C DS LWS VL+ P LI+ VH +Y +A I Sbjct: 13 LVLDGAMGTELEA--CIPKDSKIQPRKHPLWSGLVLLNEPNLIKNVHYNYLEQADVDALI 70 Query: 68 TASYQAT-PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGT-LLVAGSVGPY 125 +++YQ + P+ LD+ Q + + KS+++ A Y ++N + + + GS+GPY Sbjct: 71 SSTYQISYPSLKEHTDLDDEQIRGIWKKSIDVVEDAILQYRSKNSNSKKKIYIIGSIGPY 130 Query: 126 GAYLADGSEYRGDY-HCSVEAFQAFHRPRVEALL-DAGADLLACETLPNFSEIEALAELL 183 YLADGSEY GDY + S +++H+P +E L D D + ET+P+F E++ + +LL Sbjct: 131 ATYLADGSEYTGDYKNASDSDIESYHQPLLEYFLGDDRVDTIGFETIPSFQEVKVVLKLL 190 Query: 184 T-----AYPRARAWFSFTLRDSEHLSDGTPLRDVV----ALLAGYP----QVVALGINCI 230 + R + SF D ++DGTP V+ + L YP +V LG+NCI Sbjct: 191 SHLFAEQEKRKYYYISFNF-DEATITDGTPTEVVISYIDSFLDKYPFLRKYMVGLGLNCI 249 Query: 231 ALENTTAALQHLHGLT------VLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW 284 + + ++ + PL+VYPN Y + + + + + + +W Sbjct: 250 DYHKIGSIVAKINDSQTSAQKPLFPLIVYPNFTIKYVPEEDDYRAYKD-IEKWKELVSEW 308 Query: 285 -QAAGARLIGGCCRTTPADIAALK 307 R+IGGCC T+P +I ++ Sbjct: 309 VTIPNVRMIGGCCSTSPKEIKEVR 332 >UniRef50_B1A1E6 Homocysteine methyltransferase (Fragment) n=1 Tax=Flammeovirga yaeyamensis RepID=B1A1E6_9SPHI Length = 242 Score = 149 bits (376), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 80/220 (36%), Positives = 130/220 (59%), Gaps = 5/220 (2%) Query: 49 ELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLA 108 E+I+ HL+Y ++GA+ I++SYQA+ GF +G + L+ K+ E+A+ A+E Y Sbjct: 4 EVIKNAHLNYLKSGAEIIISSSYQASIKGFMEKGFSHEVAIDLLKKTTEIAQSAKEEYRE 63 Query: 109 ENPQAGTLLVAGSVGPYGAYLADGSEYRG-DYHCSVEAFQAFHRPRVEALLDAGADLLAC 167 + + + +AGS+GPY AYLADGSEY+G D ++FH R+ + D+LA Sbjct: 64 ISKRE--VFIAGSIGPYAAYLADGSEYKGYDEAVDENTLRSFHNERLRIIDATDIDVLAV 121 Query: 168 ETLPNFSEIEALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGI 227 ET+P+ E + L +L+ +AWFSF+ ++ + L+DGT + D+V+LL V+ALGI Sbjct: 122 ETIPSLEEAKVLNDLIEKCGH-KAWFSFSCKNEKQLNDGTDIIDIVSLLKHNNNVMALGI 180 Query: 228 NCIALENTTAALQH-LHGLTVLPLVVYPNSGEHYDAVSKT 266 NC + + L+ +V+YPN+G Y+ +KT Sbjct: 181 NCTHPKYILGLISEILNAGWKKKIVIYPNAGMVYNPDTKT 220 >UniRef50_A5DCB0 Putative uncharacterized protein n=2 Tax=Pichia guilliermondii RepID=A5DCB0_PICGU Length = 313 Score = 147 bits (371), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 97/317 (30%), Positives = 160/317 (50%), Gaps = 40/317 (12%) Query: 17 LLLDGAMATELE--ARGCNLA---DSLWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 L+LDG + +LE A N A D LWS + L+E P+LI +VH + AG T++Y Sbjct: 7 LVLDGGLGIQLETLAEKRNFAVKNDPLWSGRALIEAPDLIEDVHKSFLEAGCDIVTTSTY 66 Query: 72 QATPAGFAA-RGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLA 130 Q + A +AQ + L KSV++ +A + + ++ V G++GPYG +LA Sbjct: 67 QISRASLKKYTDFTDAQIEELWAKSVDVCWQACKFHESK------ARVCGAIGPYGGFLA 120 Query: 131 DGSEYRGDYH-CSVEAFQAFHRPRVEAL-LDAGADLLACETLPNFSEIEALAELLTAY-- 186 + +EY G+Y + + +H P L + D+LA ET+PN+ E++ + L+ Sbjct: 121 NYAEYTGEYGLITNHKLEQYHLPLATFLNNNPKVDILAFETIPNYKELKVIVNLVCKMSA 180 Query: 187 --PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGY--------PQVVALGINCIALENTT 236 P + S R+S +SDGTP+ ++ L G +++A+G NC L++ T Sbjct: 181 TGPLKPFYLSMNFRNSSQMSDGTPIEKIMGYLNGKLNKNRTLRKRLIAIGCNCTELKDAT 240 Query: 237 AALQHLHGLTV--LPLVVYPNS-GEHYDA-VSKTWHHHGEHCAQLADYLPQWQAAGARLI 292 L+++ +P +VYPN +H D + + W +Q D +W GA +I Sbjct: 241 HVLKNIETYNYHNIPTIVYPNVFADHNDTKIDQKW-------SQSVD---EWLKIGASII 290 Query: 293 GGCCRTTPADIAALKAR 309 GGCC T P IA ++ + Sbjct: 291 GGCCGTGPKQIAQIRFK 307 >UniRef50_Q08985 Homocysteine S-methyltransferase 2 n=17 Tax=Saccharomycetaceae RepID=SAM4_YEAST Length = 325 Score = 147 bits (371), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 94/330 (28%), Positives = 160/330 (48%), Gaps = 42/330 (12%) Query: 6 PLRALL--DKQDILLLDGAMATELEARGCNLADSLWSAKVLVE----------NPELIRE 53 PL+ L + + +L+LDG TELE RG +A+ +WS + N ++++E Sbjct: 5 PLKQFLADNPKKVLVLDGGQGTELENRGIKVANPVWSTIPFISESFWSDESSANRKIVKE 64 Query: 54 VHLDYYRAGAQCAITASYQATPAGFAA----RGLDEAQSKALIGKSVELARK--AREAYL 107 + D+ AGA+ +T +YQ + + R L E + L+ + V+ +R + YL Sbjct: 65 MFNDFLNAGAEILMTTTYQTSYKSVSENTPIRTLSEYNN--LLNRIVDFSRNCIGEDKYL 122 Query: 108 AENPQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEA--FQAFHRPRVEAL-LDAGADL 164 G +GP+GA++ E+ GDY E F + +P++E + DL Sbjct: 123 I-----------GCIGPWGAHIC--REFTGDYGAEPENIDFYQYFKPQLENFNKNDKLDL 169 Query: 165 LACETLPNFSEIEALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGY----- 219 + ET+PN E++A+ + + ++ + L DGT + ++ ++ Sbjct: 170 IGFETIPNIHELKAILSWDESILSRPFYIGLSVHEHGVLRDGTTMEEIAQVIKDLGDKIN 229 Query: 220 PQVVALGINCIALENTTAALQHLH-GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLA 278 P LGINC++ + L+ LH L + L+ YPNSGE YD K W + + Sbjct: 230 PNFSFLGINCVSFNQSPDILESLHQALPNMALLAYPNSGEVYDTEKKIWLPNSDKLNSWD 289 Query: 279 DYLPQWQAAGARLIGGCCRTTPADIAALKA 308 + Q+ ++GAR+IGGCCRT+P DI + A Sbjct: 290 TVVKQYISSGARIIGGCCRTSPKDIQEISA 319 >UniRef50_A7TSR2 Putative uncharacterized protein n=1 Tax=Vanderwaltozyma polyspora DSM 70294 RepID=A7TSR2_VANPO Length = 323 Score = 145 bits (367), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 95/328 (28%), Positives = 155/328 (47%), Gaps = 41/328 (12%) Query: 6 PLRALLDKQ--DILLLDGAMATELEARGCN-----------LADSLWSAKVLVENPELIR 52 P+ L+ Q ++L+ DG + T LE+RG N L D W ++ + +I Sbjct: 4 PIEELIRNQPDEVLVSDGGLGTLLESRGINVSSPLWSTVPFLKDDFWDSETKTSDRNIIE 63 Query: 53 EVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQS----KALIGKSVELARKA--REAY 106 ++ DY +G++ T +YQ + A + E ++ K LI R A + Y Sbjct: 64 GIYRDYITSGSRILSTITYQTSFALISTHT--EVKTIEGYKQLIRNITSFCRSAIGEDNY 121 Query: 107 LAENPQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQ--AFHRPRVEALLDAG-AD 163 L GS+GP+GA L G+EY G+Y S + +P++E + D Sbjct: 122 LI-----------GSIGPFGARL--GAEYTGNYGDSPSNINYLEYFKPQLEEFNNNDDID 168 Query: 164 LLACETLPNFSEIEALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQ-- 221 ++ ET+PN E+EA+ + + S +L D+ L DGT ++ + Y Sbjct: 169 IIGFETVPNKYELEAILSWDKSVISKPYYVSLSLLDNGGLRDGTSFEEIATIFKKYSNND 228 Query: 222 -VVALGINCIALENTTAALQHLH-GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLAD 279 ++ G NCI+ + + + LH + LPL+VYPNSGE YD ++K W D Sbjct: 229 NLILTGANCISFKYASENISKLHQAIPTLPLIVYPNSGEIYDPLTKKWTIDQTFGLTWED 288 Query: 280 YLPQWQAAGARLIGGCCRTTPADIAALK 307 + + + + R++GGCCRTTP DI +K Sbjct: 289 LIKELRTSNVRIVGGCCRTTPDDINKIK 316 >UniRef50_A5DTG6 Putative uncharacterized protein n=1 Tax=Lodderomyces elongisporus RepID=A5DTG6_LODEL Length = 326 Score = 140 bits (352), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 109/333 (32%), Positives = 166/333 (49%), Gaps = 41/333 (12%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADS----------LWSAKVLVENPEL 50 MSQN + +K+ ++LDGA+ T LE +L D LWS +VL++ PEL Sbjct: 1 MSQN-----IFNKK--VVLDGALGTALE----DLIDPSAPYLPSKSPLWSGQVLLDAPEL 49 Query: 51 IREVHLDYYRAGAQCAITASYQATPAGFAARG-LDEAQSKALIGKSVELARKAREA---- 105 I++VH Y AG++ T++YQ + L + Q + +S++L R A + Sbjct: 50 IQKVHEMYIGAGSEVIFTSTYQLSYDSLRKHTTLSDEQILEVWQRSIDLVRAAALSIDET 109 Query: 106 --YLAENP---QAGTLLVAGSVGPYGAYLADGSEYRGDY-HCSVEAFQAFHRPRVEALLD 159 Y E + G + +AGS+GPY AYLA+GSEY GDY + + E +AFH P +E + Sbjct: 110 ARYTKEKESRGEPGKVHIAGSIGPYAAYLANGSEYTGDYGNVTDEQLEAFHTPMLEFFTE 169 Query: 160 AGA-DLLACETLPNFSEIEALAELLTAYP-RARAWFSFTLRDSEHLSDGTPLRDVVALLA 217 A DL+A ET+PNF E++A+ +L+ + FS T ++ ++L+DGTPL +V L Sbjct: 170 NEAVDLIAFETIPNFQELKAVTKLVKRLNCKKPVLFSITCQNLDNLTDGTPLLEVKKYLD 229 Query: 218 GY--PQVVALGINCIALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTW-HHHGEHC 274 + LGINC+ + H G VYPN G YD + G Sbjct: 230 FCLPKEQKILGINCVEYTLVQGIMSHFAGFK---FYVYPNLGFEYDLEKHQFVIKEGRSE 286 Query: 275 AQLADYLPQWQAAGARL-IGGCCRTTPADIAAL 306 ++ + A + IGGCC T +I + Sbjct: 287 DDWRLFVENLASKEAVIGIGGCCNTGVKEIEQI 319 >UniRef50_C4QA25 Putative uncharacterized protein n=1 Tax=Schistosoma mansoni RepID=C4QA25_SCHMA Length = 741 Score = 134 bits (336), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 80/225 (35%), Positives = 121/225 (53%), Gaps = 10/225 (4%) Query: 15 DILLLDGAMATELEARGCNLADS--LWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 +I +LDG TE + D WS+++L+++PEL+ ++H + RAG T +YQ Sbjct: 396 EIRVLDGGFGTESQKLSNLQIDGHLAWSSRLLMDDPELVVKIHKSFLRAGCDVISTNTYQ 455 Query: 73 ATPAGFA-ARGLDEAQSKALIGKSVELARKARE-----AYLAENPQAGTLLVAGSVGPYG 126 A P+ A G+ ++K L+ +V LA++ARE +E + +L+AGS+GPYG Sbjct: 456 AAPSTLGKALGISIGEAKNLMHTAVHLAQRAREEENNSVTASEFQRKLPVLIAGSLGPYG 515 Query: 127 AYLADGSEYRGDY--HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 A ADGSEY G Y S FH R + LL++G D +A ET+P E+ ++ E++ Sbjct: 516 ACAADGSEYTGSYANEVSFNELVEFHLSRAKILLESGVDFIAWETVPLLKEVSSICEVMR 575 Query: 185 AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC 229 P A W S + D E S G L V +A QV +G+NC Sbjct: 576 RLPSAYCWISVSSPDGEKTSGGDLLASVACEVAKCEQVFGVGVNC 620 >UniRef50_B6KB25 Homocysteine S-methyltransferase-1 n=3 Tax=Toxoplasma gondii RepID=B6KB25_TOXGO Length = 434 Score = 132 bits (331), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 101/327 (30%), Positives = 146/327 (44%), Gaps = 67/327 (20%) Query: 15 DILLLDGAMATELEARGCNL-ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 DILLLDG + T L A G D LW++K ++ P+L+R H D++ AGA AITA+YQA Sbjct: 9 DILLLDGGLGTHLRALGAEFHGDPLWASKAVLSAPDLVRRAHFDFFDAGADVAITATYQA 68 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAR--------------EAYLAENPQAGTLLVA 119 + GFA GL + + + ++ LA +AR E E P+ L A Sbjct: 69 SLTGFAQIGLSPSTAHDAVALAINLAAEARRLAEEGDVSARSFGEERENEGPEVDALRNA 128 Query: 120 G----------------------------SVGPYGAYLADGSEYRGDYHCSVEAFQAFHR 151 S G YGA L G+EYRG+Y S + F +HR Sbjct: 129 ATSDTDSVQQGNARDADRRYRRRNRKILVSNGSYGASLGGGAEYRGNYGVSEKTFHDYHR 188 Query: 152 PRVEALLDAG--ADLLACETLPNFSEIEALAELLTAYP--RARAWFSFTLRDSEHLSDGT 207 R++A L+ D + ETLP +E +A+ LL +P R + W +FT + L+ G Sbjct: 189 WRLQAALEQEHLVDGVVFETLPEHAEAKAIVSLLREFPSLRGKTWLAFTCKSPTELAGGE 248 Query: 208 PLRDVVALL---AGYPQVVA-LGINCIALENTT-------------AALQHLHGLTVLPL 250 R VVA + G Q ++ +G+NC + T A+L+ L + Sbjct: 249 DFRSVVADVLKQDGADQYISGIGVNCAPISTTVPLLCSPPLRDSLAASLEKTRDPWSLQV 308 Query: 251 VVYPNSG---EHYDAVSKTWHHHGEHC 274 V YPN+ D SK + E C Sbjct: 309 VCYPNNEAARNTKDCSSKDFESQEESC 335 >UniRef50_B7G9Z1 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B7G9Z1_PHATR Length = 418 Score = 130 bits (328), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 120/372 (32%), Positives = 168/372 (45%), Gaps = 81/372 (21%) Query: 16 ILLLDGAMATELEAR-GCNLADSLWSAKVLVEN-------------------PELIREVH 55 IL+LDG ++T LE+ ADS S K+ L+R+ H Sbjct: 33 ILVLDGGVSTHLESNLSSTNADSASSDKLSCRTCAFPHRELWSSSLLLSESGRRLVRQGH 92 Query: 56 LDYYRAGAQCAITASYQAT------PAGFAA------RGLDEAQSKALIGKSVELARKAR 103 D+ RAGA T +YQ P G A R +D+A L VE+A++A Sbjct: 93 DDWLRAGANVLSTVTYQCHYQAAYWPKGKMATNDKDSRVMDDAVVNTLWNDGVEIAQQAV 152 Query: 104 EAYLAENPQAGTL------------LVAGSVGPYGAYLADGSEYRGDY-HCSVEAFQAFH 150 + Y + TL V S G YGA LA+G+EY G+Y +V+ FH Sbjct: 153 KDYCHNQQRPHTLRQPELETSSVPRYVVASSGCYGAILANGAEYTGNYGPVTVDDLVHFH 212 Query: 151 RPRVEALLDAGADLLACETLPNFSEIEALAELLT----AYP----RARAWFSFTLRDSEH 202 R +V + D +A ET+P+ E AL +L A P + W S + R+ Sbjct: 213 RRKVRRAVQLHPDGIAIETVPSLLECHALVQLFQPTNGAAPMLLNKTACWISLSCRNERE 272 Query: 203 LSDGTPLRDVVALLAGYP--QVVALGINCIALENTTAAL----QHL----HGLTVLPLVV 252 L+DGTPL + +L+ P V A G+NC ++ + A + QH+ G LV+ Sbjct: 273 LNDGTPLVAALNVLSQIPCTAVSAWGLNCCSVTHLPALVRILTQHVAQEASGKHRRGLVL 332 Query: 253 YPNSGEHYDAVSKTWHHHGEHC-----------AQLADYLPQWQ------AAGARLIGGC 295 YPNSGE +DAV+ TW H G C A L +W+ + LIGGC Sbjct: 333 YPNSGELWDAVTGTW-HTGTGCTAPAAMASEIVAVLRTVEDEWRRHRPTDPTPSILIGGC 391 Query: 296 CRTTPADIAALK 307 CRT+PA IAAL+ Sbjct: 392 CRTSPATIAALR 403 >UniRef50_A4XIN5 Methylenetetrahydrofolate reductase n=1 Tax=Caldicellulosiruptor saccharolyticus DSM 8903 RepID=A4XIN5_CALS8 Length = 604 Score = 122 bits (306), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 104/314 (33%), Positives = 147/314 (46%), Gaps = 41/314 (13%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSL-WSAKVLVENPELIREVHLDYYRAGAQC 65 R L +QDI+L DGAM TEL RG N L W+ + NP+L++ +H DY AG+QC Sbjct: 4 FREFLSQQDIVLFDGAMGTELLNRGYNKDFPLEWAN---ISNPDLVKSIHSDYILAGSQC 60 Query: 66 AITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAG-TLLVAGSVGP 124 T ++ A G E Q + + +V++A++ AG T V GSVGP Sbjct: 61 IETNTFGANECRLNLYGF-EGQVEKINRNAVKIAKEV----------AGQTAYVIGSVGP 109 Query: 125 YGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE----IEALA 180 G + G E V ++ ++ LLD G D + ET + E IEAL Sbjct: 110 LGKPVGSGFEIDDKRAKEV------YKKQLYFLLDEGVDAILFETAASTHEVLIAIEALK 163 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-----IALENT 235 EL + +P FSFT RD + G + V+ L G V +G+NC LE Sbjct: 164 ELDSNFPYI-VQFSFT-RDLTTIY-GEDIYKVIEFLKGIDADV-VGLNCGNGPHQTLEAL 219 Query: 236 TAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGC 295 QHL G P V PN+G Y + + + A ++ ++ GA++IGGC Sbjct: 220 KIFSQHLKG----PFSVQPNAG--YPQLVQGRLVYSTSANYFASFVDEYVKYGAKIIGGC 273 Query: 296 CRTTPADIAALKAR 309 C TTP I A+K R Sbjct: 274 CGTTPEHIKAIKER 287 >UniRef50_UPI0000E4900F PREDICTED: similar to 5-methyltetrahydrofolate:homocysteine methyltransferase n=2 Tax=Strongylocentrotus purpuratus RepID=UPI0000E4900F Length = 172 Score = 119 bits (298), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 65/163 (39%), Positives = 91/163 (55%), Gaps = 11/163 (6%) Query: 146 FQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSFTLRDSEHLSD 205 + +HRPR++AL+D DLLA ET+P+ E EAL +L +P +AW +F +D H+ Sbjct: 6 LKQWHRPRIQALVDGKVDLLAIETIPSIVEAEALLSVLQEFPSMKAWLTFYCKDKSHIGH 65 Query: 206 GTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLH-GLTVLPLVVYPNS-GEHY--D 261 G + V ++ Q+V +G NCIA EN TA LQ P VVYPN+ GE + D Sbjct: 66 GESFAEAVGKVSACSQIVGVGTNCIAAENVTALLQGASTSRNGKPFVVYPNAPGEQWIDD 125 Query: 262 AVSKTWHHHGEHCA-QLADYLPQWQAAGARLIGGCCRTTPADI 303 +V G+ A + D +P W AG + IGGCC T+ DI Sbjct: 126 SVC------GKTAADEFDDLIPAWIEAGVKYIGGCCGTSALDI 162 >UniRef50_Q753B4 AFR410Wp n=1 Tax=Eremothecium gossypii RepID=Q753B4_ASHGO Length = 370 Score = 117 bits (292), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 88/314 (28%), Positives = 143/314 (45%), Gaps = 33/314 (10%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENP----ELIREVHLDYYRAGAQCAIT 68 ++++L++DG M ELE RG ++ LWS + + IR ++ ++ AG++ T Sbjct: 56 ERNVLVMDGGMGVELERRGMDVKSPLWSTAPFLRGDRAALDTIRGLYREFRAAGSRGIST 115 Query: 69 ASYQAT---PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY 125 +YQA+ ++ A + + + V+ + E + GSVGPY Sbjct: 116 LTYQASFHSMVKYSGSVSSRADYEKFLEQVVDFTYR-------ECVDPARDYIIGSVGPY 168 Query: 126 GAYLADGSEYRGDYHCSVEAFQAFHRPRVEAL-LDAGADLLACETLPNFSEIEALAE--- 181 A+L +G+EY GDY F + P+V D D +A ET+PN E+ A+ + Sbjct: 169 AAFLCNGAEYTGDYGFETINFFNYFEPQVSKFATDPRIDAIAFETVPNVVELMAMLQPEF 228 Query: 182 --LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGY-----PQVVALGINCIALEN 234 LL P + S + +D L DGTPL V L+ P ++ G+NC+ L Sbjct: 229 HALLKNKP---FYISISAKDEHVLRDGTPLAVVGQLIRERMDDLPPNLLCFGLNCVDLTR 285 Query: 235 TTAALQHLH-GLTVLPL---VVYPNSGEHYDAVSKTWHHHGE-HCAQLADYLPQWQAAGA 289 + A L L+ L P+ +YPN +D W + A+ + + Sbjct: 286 SAAMLAELNMQLQDCPIKFQAIYPNGTSVFDESLSAWRPSKDAESLTWAEAVKLYLNQDC 345 Query: 290 RLIGGCCRTTPADI 303 R+IGGCC TTP D+ Sbjct: 346 RMIGGCCGTTPQDM 359 >UniRef50_B8PAR1 Predicted protein (Fragment) n=1 Tax=Postia placenta Mad-698-R RepID=B8PAR1_POSPM Length = 380 Score = 117 bits (292), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 112/378 (29%), Positives = 158/378 (41%), Gaps = 87/378 (23%) Query: 16 ILLLDGAMATELE-ARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 +L+LDG T LE +++ LWSA+ + +NPELI HL + RAGA +T++YQ Sbjct: 1 VLILDGGFGTTLEDVFHQDISTPLWSARPIEDNPELIIAAHLAFLRAGADVILTSTYQCA 60 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGT------------LLVAGSV 122 F G ++ K+V LA +AR Y E T + +A S+ Sbjct: 61 FQTFERSGYTREDGVRILRKAVLLATEARRQYKEEGAPDDTSTGLSGTAHVRDIKIALSL 120 Query: 123 GPYGAYLADGSEYRGDY-----------------------------HCSVEAFQAFHRPR 153 GP+GA L+ E+ G Y +V A AFH R Sbjct: 121 GPFGATLSPAQEFDGFYPPPYGPKGLSQEGGNYNAFPDSDDGKAQEEKAVAALTAFHLER 180 Query: 154 VEALLD-----AGADLLACETLPNFSEIEAL---AELLTAYPRARA----WFSFTLRDSE 201 + AL++ A D +A ET+P EI A+ ELL A A W S Sbjct: 181 LRALVEDVETWAAIDFVAFETVPLVREIRAIRHAMELLVQENGASAAKPWWISTVYPGGR 240 Query: 202 HLSDGTP------LRDVVALLAG--------YPQVVALGINCIA----------LENTTA 237 + +P +R VV + G P LG+NC + N Sbjct: 241 FPQERSPGEGRLTVRIVVEAIMGEGRLGAPQSPAPWGLGVNCTEPQFIGGLLKEMTNIME 300 Query: 238 ALQHLHGLTVLP-LVVYPNSGEHYDAVSKTWHHHGEHCAQ---LADYLPQWQAAGAR--- 290 L + G + P LVVYPN G+ YDA S+TW E Q + + + AG++ Sbjct: 301 GLGNTAGRSQSPWLVVYPNRGDVYDAASQTWSKGAESIRQNWAVHVWADVQRVAGSKAWS 360 Query: 291 --LIGGCCRTTPADIAAL 306 LIGGCC+T P +IA L Sbjct: 361 GCLIGGCCKTGPQEIAEL 378 >UniRef50_C4WWI3 ACYPI009247 protein n=4 Tax=Acyrthosiphon pisum RepID=C4WWI3_ACYPI Length = 199 Score = 115 bits (289), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 61/153 (39%), Positives = 90/153 (58%), Gaps = 7/153 (4%) Query: 38 LWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPAGFAAR-GLDEAQSKALIGKSV 96 LW + ++ N E + + H DY RAGA+ T +YQA+ GF L+ QS LI KSV Sbjct: 36 LWGSNLIFNNEEAVVKAHRDYIRAGAEFLTTNTYQASIEGFQKYLNLNYDQSFQLIKKSV 95 Query: 97 ELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAF--HRPRV 154 + R+A + E T+ + GSVGPYGA L DGSEY G+Y +++ + H+PR+ Sbjct: 96 TICRRA----IMEESSGRTIRIMGSVGPYGASLCDGSEYNGNYIGKIDSKDLYDWHKPRI 151 Query: 155 EALLDAGADLLACETLPNFSEIEALAELLTAYP 187 +AL++AG D++ ET+P+ E L +L YP Sbjct: 152 QALVEAGVDVVLFETIPSIIEANILLNILAEYP 184 >UniRef50_C1C2Y0 Homocysteine S-methyltransferase 1 n=1 Tax=Caligus clemensi RepID=C1C2Y0_9MAXI Length = 391 Score = 113 bits (282), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 89/331 (26%), Positives = 142/331 (42%), Gaps = 71/331 (21%) Query: 8 RALLDKQDILLLDGAMATELEARGCNLADSL-----WSAKVLVENPELIREVHLDYYRAG 62 R L + +I +LDG +T+++ DS W++++ ENPE ++ H+DY Sbjct: 11 RVLGSRNEIFILDGGFSTQIQQHAG--KDSFEGRPQWTSELNTENPEAVKRSHMDYLSNC 68 Query: 63 AQCAITA-SYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGS 121 + I++ +YQA + I K+VEL EA L + + GS Sbjct: 69 SGDLISSNTYQAASSS--------------IEKAVELCD---EAILEASHVPRKAGIVGS 111 Query: 122 VGPYGAYLADGSEYRGDYHCSV-----EAFQAFHRPRVEALLDAGADLLACETLPNFSEI 176 +GPY A+ GSEY S E + +++ R+ L+ AG D++A ET+P E Sbjct: 112 LGPYAAFQPSGSEYNSSDGMSYPPLADEELKEWYKDRIRHLMIAGVDVIAFETMPCIKEA 171 Query: 177 EALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVA-----LGINCIA 231 +++ A+ W SF RD +HL+ G +D V L +P V +GINC + Sbjct: 172 LVALDIIDNVINAKCWISFQCRDGKHLAYGESFKDAVERLLNHPAFVKRKLLYIGINCTS 231 Query: 232 LENTTAALQ------------HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLAD 279 + ++ L+ +G +P VVYPN G + E C + D Sbjct: 232 PKYISSLLKLAERVNKKMNFPDKYGYWRIPYVVYPNRGVYCK----------EKCCYVLD 281 Query: 280 Y--------------LPQWQAAGARLIGGCC 296 +W G R+IGGCC Sbjct: 282 KDDPLGGGDEGILKRCHEWMLLGTRVIGGCC 312 >UniRef50_B9MN09 Methylenetetrahydrofolate reductase n=2 Tax=root RepID=B9MN09_ANATD Length = 605 Score = 111 bits (277), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 102/315 (32%), Positives = 142/315 (45%), Gaps = 43/315 (13%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSL-WSAKVLVENPELIREVHLDYYRAGAQC 65 R L +Q I++ DGAM T+L RG ++ L W+ V NPEL++++H DY AGA C Sbjct: 5 FREFLKEQAIVIFDGAMGTQLLLRGFSVDFPLEWAN---VANPELVKQIHTDYILAGATC 61 Query: 66 AITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY 125 T ++ A G + + I +S R A+E +AEN + V GSVGP Sbjct: 62 VETNTFGANECKLKVFGFENEVER--INRSA--VRIAKE--VAEN----KVYVIGSVGPL 111 Query: 126 GAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE----IEALAE 181 G + +G E V Q + LLD G D + ET + E IEAL E Sbjct: 112 GKPVGNGFEIDDKKAKDVYKRQLYF------LLDEGVDAIIFETAASTHEVQIAIEALKE 165 Query: 182 LLTAYPRARAWFSFTLRDSEHLSD--GTPLRDVVALLAGYPQVVALGINC-----IALEN 234 L P FSFT + LS G + V+ L V +G+NC LE Sbjct: 166 LNDKIPYI-IQFSFT----KELSTVYGEDIYRVIEFLKSTNADV-VGLNCGNGPQKTLEA 219 Query: 235 TTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGG 294 QHL G P V PN+G Y + + A ++P++ GA++IGG Sbjct: 220 LKIFSQHLKG----PFSVQPNAG--YPQLIQGRPVFSTSANYFASFVPEYIKLGAKIIGG 273 Query: 295 CCRTTPADIAALKAR 309 CC T P I A+K + Sbjct: 274 CCGTGPEHIKAVKEK 288 >UniRef50_C5E3E4 KLTH0H12716p n=1 Tax=Lachancea thermotolerans CBS 6340 RepID=C5E3E4_LACTC Length = 348 Score = 107 bits (267), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 90/330 (27%), Positives = 144/330 (43%), Gaps = 41/330 (12%) Query: 6 PLRALLDKQDILLLDGAMATELEARGCNLADSLWSA-KVLVENP---ELIREVHLDYYRA 61 PL+ K +ILLLDG TELE +G +++ LWS +++N E I+E++ D+ A Sbjct: 4 PLKEFF-KNNILLLDGGQGTELEKKGVSISHPLWSTLPFIIKNKTHLEAIKEMYRDFAEA 62 Query: 62 GAQCAITASYQATPAGFA--ARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVA 119 G+ +T +YQA+ + + GL ++ + RE + + Sbjct: 63 GSNALMTITYQASFSSMKKYSEGLVNSEEDYAAFLDYVIGFTDRECITPDK------YLV 116 Query: 120 GSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEAL-LDAGADLLACETLPNFSEIEA 178 GSVGPY L++G+EY G Y F ++ P+V+ L DL+ ET+PN E +A Sbjct: 117 GSVGPYAGLLSNGAEYSGYYGEGKIDFIDYYSPQVKHFALSPRIDLIGIETIPNIDEFKA 176 Query: 179 L--AELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQV-----VALGINCIA 231 L E + S T ++ L DGT L ++ + + V INC+ Sbjct: 177 LLSPEFSRLSFSKPYYISVTTDNNGCLRDGTSLNEICRAIKQSASLLPDNFVFFAINCVE 236 Query: 232 LENTTAALQHLHGLTVLPLV--------VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQ 283 + LQ L+ + V YPNSGE Y + +W + A Sbjct: 237 FLHCVEILQSLNDCLEMQGVDRRFRFRGAYPNSGEIYHGGTHSWSSN-----PYAGPEDT 291 Query: 284 WQ-------AAGARLIGGCCRTTPADIAAL 306 W+ + ++GGCCRT +I + Sbjct: 292 WENLTLGLLSQECLMLGGCCRTGSEEIRQM 321 >UniRef50_Q28RZ7 Homocysteine S-methyltransferase n=13 Tax=Rhodobacteraceae RepID=Q28RZ7_JANSC Length = 297 Score = 106 bits (265), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 100/315 (31%), Positives = 141/315 (44%), Gaps = 50/315 (15%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 +I +LDG M EL +R LWS V+ P L+ EVH D++ AGAQ A TA+ A Sbjct: 3 EITILDGGMGQELVSRSDVPPTPLWSTDVMRAKPHLVGEVHRDFFNAGAQIA-TANTYAI 61 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 R EA+ +L +++ AR+AR+A+ G+ LVAG++GP GA Sbjct: 62 HRDRLVRADAEAEFASLHKTALDQARQARDAH-------GSGLVAGAIGPLGA------S 108 Query: 135 YRGDY---HCSVEAFQA----FHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYP 187 YR D H + A A H P V DLL CET+ + ++ EA+ + + Sbjct: 109 YRPDLTPQHSAAVALYAEIATLHAPLV--------DLLICETITSLAQAEAVLDACLGH- 159 Query: 188 RARAWFSFTL--RDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL 245 W +F++ RD L G L DV+A+ + AL NC E AAL L G Sbjct: 160 GVPVWLAFSVDDRDGTRLRSGEGLGDVIAMAG---EAAALLANCSVPEVMPAALDIL-GR 215 Query: 246 TVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQL-----------ADYLPQWQAAGARLIGG 294 P Y N + +S + L AD++ W GA ++GG Sbjct: 216 AGTPFGAYANG---FTEISAGFLDDAPTVDALTSRTDMGPEAYADHVMGWIDQGATIVGG 272 Query: 295 CCRTTPADIAALKAR 309 CC PA IA + R Sbjct: 273 CCEVGPAHIAEITRR 287 >UniRef50_Q2LWJ5 5-methyltetrahydrofolate--homocysteine methyltransferase n=6 Tax=Bacteria RepID=Q2LWJ5_SYNAS Length = 813 Score = 106 bits (264), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 100/318 (31%), Positives = 147/318 (46%), Gaps = 46/318 (14%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGC--NLADSLWSAKVLVENPELIREVHLDY 58 M +R LL K+ IL+LDGA TEL+ RG + LW +E+PE+I+E+H Y Sbjct: 1 MKSKETIRRLLKKK-ILVLDGATGTELQKRGMPGGVCPELWC----LEHPEIIKEIHRSY 55 Query: 59 YRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLV 118 +AG+ T ++ A A G E + I ++ LAR AR A P+A LV Sbjct: 56 RQAGSDIVYTCTFGANRYKLAQYGTREVRE---INRN--LARLARHAV---GPKA---LV 104 Query: 119 AGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 AG +GP G ++ E GD EA AF + +++ LL+ G DL ET+ + E A Sbjct: 105 AGDIGPTGHFV----EPFGDLPFE-EAVSAF-KEQIQGLLEGGVDLFVIETMMDIQEARA 158 Query: 179 LAELLTAYPRARAWFSFTLRDSEHLSDGT-PLRDVVALLAGYPQVVALGINC-IALENTT 236 + A + T + +GT P ++ L + A+G NC E Sbjct: 159 ALIAVKETCPAFTVVTLTYENGGRTLNGTDPATALITLQSLGAD--AVGCNCSTGPEAML 216 Query: 237 AALQHLHGLTVLPLVVYPNSG--------EHYDAVSKTWHHHGEHCAQLADYLPQWQAAG 288 A ++ + +PL PN+G +D ++T+ HG P + AAG Sbjct: 217 AFIEAMKPHATVPLAAKPNAGLPRLEGEETFFDMDAETFASHG----------PAFAAAG 266 Query: 289 ARLIGGCCRTTPADIAAL 306 L+GGCC TTP I AL Sbjct: 267 VNLLGGCCGTTPDHIQAL 284 >UniRef50_C8VHP4 Homocysteine S-methyltransferase (Eurofung) n=5 Tax=Eurotiomycetidae RepID=C8VHP4_EMENI Length = 355 Score = 106 bits (264), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 105/351 (29%), Positives = 161/351 (45%), Gaps = 61/351 (17%) Query: 16 ILLLDGAMATELEARGCNLADS----LWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 ILLLDG + T LE+ N+ + LWS+ +L+ +P ++ H +Y AGA +TA+Y Sbjct: 3 ILLLDGGLGTTLESYPFNITFTSETPLWSSHLLISSPSTLQSAHRAFYDAGADILLTATY 62 Query: 72 QATPAGFAARGLDEAQSKA--LIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYL 129 Q++ GFA + A + ++ L R A + + PQ VA S+GPYGA + Sbjct: 63 QSSIEGFARTDASHTINDAGDYMRSAIPLVRGAIPSSARQRPQ--QCRVALSLGPYGATM 120 Query: 130 AD-GSEYRGDYHCSV---EAFQAFHRPRVEALLD-----AGADLLACETLPNFSEIEALA 180 + +EY G Y + +A + +H R+ +D D +A ETL E+ A+ Sbjct: 121 SPVAAEYTGAYPPEMDGEDALRQWHAGRLNVFVDDRESWDQVDFVAFETLIRADEVCAVR 180 Query: 181 ELLT-------AYPRARAWFSFTLRDSEHLSDGTPLRD----VVALLAGYPQVVALGINC 229 + + R + W+ + +E + D T +R V G P+ +G+NC Sbjct: 181 GAMKDVCVGPEIHRRRKPWWICGVFPAEEV-DRTQVRQWVDAAVGQRPGLPRPWGIGLNC 239 Query: 230 IALENTTAAL----QHLHGL----------------TVLP-LVVYPN--SGEHYDAVSKT 266 +EN + LH L + P LV+YP+ GE YD V+KT Sbjct: 240 TRIENVAKIVAIMRDELHCLLSRGKEDGFVDEWDAASGKPWLVLYPDGTKGEKYDPVTKT 299 Query: 267 W--HHHGEHCA---QLADYLPQWQAAG---ARLIGGCCRTTPADIAALKAR 309 W C L D + Q Q+ G ++GGCCR PADIAAL+ R Sbjct: 300 WVARETVVRCPWDESLWDVV-QGQSEGDWEGIIVGGCCRAGPADIAALRRR 349 >UniRef50_C6HW85 5-methyltetrahydrofolate--homocysteine methyltransferase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HW85_9BACT Length = 822 Score = 105 bits (261), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 90/296 (30%), Positives = 145/296 (48%), Gaps = 35/296 (11%) Query: 13 KQDILLLDGAMATELEARGC--NLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITAS 70 K+DIL+LDG+M L+ RG A LW+ +E P+ I+ VH +Y AG+ +T + Sbjct: 9 KKDILILDGSMGALLQGRGLPPGYAPDLWN----LERPKDIQAVHAEYRAAGSDILLTNT 64 Query: 71 YQATPAGFAARGLDEAQSKALIGK----SVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 + G + R L E Q++ I + VELAR+A + G +AG +GP+G Sbjct: 65 F-----GASRRRLAEYQAEGRIREINHAGVELARRAAQ---------GKAYIAGDIGPFG 110 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 + +A GD + E R + L +AG DL+A ET+ + E+ A + Sbjct: 111 STIAP----FGD--TTFEEAVGIFREQASILAEAGVDLIAIETMFDIQEMRAALIGVREG 164 Query: 187 PRARAWFSFTLRDSEHLSD-GTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHG 244 +F +++ ++D G+ V A+L G+ V +G+NC + E L+ L Sbjct: 165 APGVPIMAFMTYNADGITDSGSDPETVAAVLEGF-SVEIMGLNCSVGPEAMLPVLERLGR 223 Query: 245 LTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 T L + PN+G KT + G +++A + P + AGA ++GGCC TTP Sbjct: 224 ATHTYLGIEPNAGLPVHRDGKTVYPLG--ASEMASFAPAFADAGANIVGGCCGTTP 277 >UniRef50_D2W5I3 Predicted protein (Fragment) n=2 Tax=Naegleria gruberi RepID=D2W5I3_NAEGR Length = 661 Score = 104 bits (260), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 90/316 (28%), Positives = 137/316 (43%), Gaps = 67/316 (21%) Query: 9 ALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAI- 67 L+D++ IL+LDG ++T + G L SLW A L+ENP+ I +VH DY G C I Sbjct: 327 VLVDRK-ILILDGGISTYMTELGLELNGSLWGANYLLENPKAIAKVHSDYVHEGL-CDIC 384 Query: 68 -TASYQATPAGFAARGLDEAQSKA------LIGKSVELARKAREAYLAENPQAGTLLVAG 120 ++SYQ + G AA + + + + SV++ARK + LVA Sbjct: 385 TSSSYQISQEGLAADHVSMKEEERIELASRMFRDSVQIARKV--------VREKEKLVAA 436 Query: 121 SVGPYGA----YLADGSEYRGDY-------------HCSVEAFQA--------------- 148 SV +GA L + EY GDY H V+ Sbjct: 437 SVSCFGASISNLLGEAKEYFGDYLDKDVDSNSGHYVHKFVKQLSEKLGETLEKSGMEQVI 496 Query: 149 --FHRPRVEALLDAGADLLACETLPNFSEIEALAE-----LLTAYPRA--RAWFSFTLRD 199 FH PRV L+ A D + ET+P E+E L + +L + + SF +D Sbjct: 497 YDFHYPRVRELILAEPDFILLETMPVLKEVEILCDRVIPDILKELNKKGIKVMISFYCKD 556 Query: 200 SEHLSDGTPLRDVVALLA------GYPQVVALGINCIALENTTAALQ--HLHGLTVLPLV 251 H G + V + ++ A+G NCI+ ++ H H + ++ Sbjct: 557 GLHTGHGESIEKCVEYVNQDRFNPSLFEIFAVGANCISPSIVPILIENIHTHLRKDISII 616 Query: 252 VYPNSGEHYDAVSKTW 267 +YPNSGE YD ++K+W Sbjct: 617 LYPNSGEIYDNLTKSW 632 >UniRef50_A4R5G4 Putative uncharacterized protein n=1 Tax=Magnaporthe grisea RepID=A4R5G4_MAGGR Length = 374 Score = 103 bits (258), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 107/372 (28%), Positives = 167/372 (44%), Gaps = 80/372 (21%) Query: 15 DILLLDGAMATELEARGCNL---ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 DI +LDG + T LE R + A LWS+ +LV + E ++ ++ AGA +TA+Y Sbjct: 3 DIKILDGGLGTTLEDRFGVVFTHAKPLWSSDLLVSDQETLQACQREFAAAGADVLLTATY 62 Query: 72 QATPAGFAARGLDE-----AQSKALIG---KSVELARKA---------------REAYLA 108 Q + FA E A S A++ +VE+A KA R A Sbjct: 63 QVSVEAFARTKTPEHPDGIAPSSAMLPYLRGAVEIAEKAAAAAAAAAAAAAAAPRNETSA 122 Query: 109 ENPQAGTLLVAGSVGPYGAYLADGSEYRGDY---HCSVEAFQAFHRPRVEALLDAGADL- 164 +PQ L +A GPYGA + G EY G Y H + +A +H R+ AG D+ Sbjct: 123 PSPQPAELALA--CGPYGAAMTPGQEYTGAYDAAHSTPDALSRWHLDRLALYAAAGEDVP 180 Query: 165 -----LACETLPNFSEIEALAELLT---------AYPRARAWFSFTL-RDSEHLSDGTPL 209 +A ET+PN +E+ A+ + +T +P +R W + E L+DG+ + Sbjct: 181 GRCAYVAFETVPNLAEVWAVRDAITRLRQDASCSRFP-SRFWICCVFPHEDERLADGSSV 239 Query: 210 RDVV-ALLA--------GYPQVVAL----GINCI----------ALENTTAALQHLHGLT 246 VV A+LA G + +AL GINC + E + + L+ +T Sbjct: 240 DQVVEAMLAARGGGENGGAKESLALPWGIGINCTKIYKLEGLIKSFERSISGLKAKGVIT 299 Query: 247 VLP-LVVYPN--SGEHYDAVSKTW------HHHGEHCAQLADYLPQWQAAGARLIGGCCR 297 +P LV+YP+ +GE Y+ ++ W G Q+ + + L+GGCC+ Sbjct: 300 NVPALVLYPDGTNGEVYNTTTQKWEAPQVVQGAGPKLTQIVNDTKSRGVFTSFLVGGCCK 359 Query: 298 TTPADIAALKAR 309 P +I L+ R Sbjct: 360 ANPQNIKDLRNR 371 >UniRef50_Q5PNQ2 Novel protein containing a homocysteine S-methyltransferase domain (Fragment) n=2 Tax=Eumetazoa RepID=Q5PNQ2_DANRE Length = 140 Score = 103 bits (258), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 48/121 (39%), Positives = 81/121 (66%), Gaps = 4/121 (3%) Query: 82 GLDEAQSKALIGKSVELARKAREAYLAENPQAGTL--LVAGSVGPYGAYLADGSEYRGDY 139 G+ +++ ++ +V+LA++ +++++P + LVAGSVGPYG++L DGSEY G Y Sbjct: 8 GVQPEEAQHMMMSAVQLAKETVSEFISQSPMSDRREPLVAGSVGPYGSFLHDGSEYTGAY 67 Query: 140 H--CSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSFTL 197 +VE + +HRP+++ L+ AGADL+A ET+P E EAL ++L +P +AW SF+ Sbjct: 68 EDKMTVEELKDWHRPQIQCLVKAGADLVAMETIPGLKEAEALVKVLKEFPETKAWLSFSC 127 Query: 198 R 198 + Sbjct: 128 K 128 >UniRef50_D1CBD0 Methylenetetrahydrofolate reductase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CBD0_THET1 Length = 629 Score = 102 bits (254), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 101/320 (31%), Positives = 152/320 (47%), Gaps = 48/320 (15%) Query: 4 NNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGA 63 +P L+K IL DGA+ T+L RG S ++ +P L+ VH+DY RAGA Sbjct: 2 KDPFVERLEKGPILS-DGAIGTQLYERGVPYGKSFDELNIV--DPSLVSGVHIDYLRAGA 58 Query: 64 QCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVG 123 + T ++ A GL E + + + + V++AR+ARE + P +AGSVG Sbjct: 59 EIITTNTFGANRIRLKEFGL-EKKVRDINLRGVKIAREARE--IVGVPA----FIAGSVG 111 Query: 124 PYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 P G +EY + R ++EALL+ GAD++ ET FSE+E ELL Sbjct: 112 PIGR---PATEYN---SLTDRVIGDTFREQIEALLEGGADVIMFET---FSELE---ELL 159 Query: 184 TAYPRAR--------AWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALEN 234 A A+ A SF + H D TP V AL V +G+NC + + Sbjct: 160 IAIEVAKEVCELPIIAQMSFGEDELTHGGD-TPEDFVRALKDS--DVDVIGVNCSVGPQG 216 Query: 235 TTAALQHL-----HGLTVLPLVVYPNS-GEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG 288 T + L H ++ P P+ G+H+ +S + A+Y ++ +AG Sbjct: 217 TLDVVMRLIAAGAHRVSAQPNAGLPSRRGQHFVYISTPEY--------FAEYAKKFVSAG 268 Query: 289 ARLIGGCCRTTPADIAALKA 308 A ++GGCC TTPA I+A+ A Sbjct: 269 AVIVGGCCGTTPAHISAMAA 288 >UniRef50_A4J6L9 Methionine synthase (B12-dependent) n=1 Tax=Desulfotomaculum reducens MI-1 RepID=A4J6L9_DESRM Length = 800 Score = 102 bits (254), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 87/297 (29%), Positives = 141/297 (47%), Gaps = 25/297 (8%) Query: 13 KQDILLLDGAMATELEARGC--NLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITAS 70 K+++L++DGAM T L+ RG W+ + +PE ++E+H Y AGA T + Sbjct: 8 KKEVLIIDGAMGTLLQQRGLPGGWCPEEWN----LSHPEAVKEIHKLYLEAGADIITTNT 63 Query: 71 YQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLA 130 + A A L + Q K + +V+LA++ + Y A +VAGSVGP G +L Sbjct: 64 FGAIQLKLADYHLGD-QVKEINQAAVKLAKEVAQPYGA--------MVAGSVGPLGKFLQ 114 Query: 131 DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRAR 190 + EA+Q F+ + A+++AG DL+ ET + E+ A Sbjct: 115 PLGTMTFE-----EAYQQFYE-QCAAMVEAGVDLILFETFGDIGEMRAALIAAADAGDVP 168 Query: 191 AWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLP 249 SFT ++ GT + A++A + A+G+NC + ++ L T LP Sbjct: 169 VVASFTFDETGRTFTGTD-PETAAVVAERLGIAAIGVNCSVGPRQLEGVVRKLTESTNLP 227 Query: 250 LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 ++V PN+G KT E +A+Y ++ GA ++GGCC TTP I A+ Sbjct: 228 VLVSPNAGMPEIIGGKTVFR--ETPEIMAEYAQRFVDYGASILGGCCGTTPKHIQAI 282 >UniRef50_B8CZI7 Homocysteine S-methyltransferase n=1 Tax=Halothermothrix orenii H 168 RepID=B8CZI7_HALOH Length = 819 Score = 102 bits (254), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 84/297 (28%), Positives = 140/297 (47%), Gaps = 26/297 (8%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 ++ I++ DGAM T L+A C L+ +++ P+ I ++H +Y AGA T ++ Sbjct: 10 QEKIIIGDGAMGTMLQA--CGLSSGHAPESWVIKKPDTIYKIHKEYVAAGAGLIETNTFG 67 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A + GL++ + + K+ LARKA AG + VAGSVGP G + Sbjct: 68 ANRLKLKSLGLEDKIEEINV-KATGLARKA----------AGKVFVAGSVGPTGKLM--- 113 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPR-ARA 191 E GD S + + + ++ L+ AG D++ ET+ + E+ A + A Sbjct: 114 -EPHGD--LSFDRARDVFKEQISYLVHAGVDVVIIETMSDLKELRAAVVAAKEFNVPVIA 170 Query: 192 WFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIA-LENTTAALQHLHGLTVLPL 250 +FT R L+ P +VVA++ V +G+NC+A +E ++ + +T PL Sbjct: 171 QMTFTER-GITLTGSPP--EVVAIVLDKMGVDVIGVNCVAGIEEALIVIKKMSRVTSKPL 227 Query: 251 VVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 V+PN+G +T + D +P+ +LIGGCC T P I +K Sbjct: 228 SVFPNAGLPESKGGETVYPQTPDA--FTDKIPELLKYNVKLIGGCCGTNPRFIKGIK 282 >UniRef50_D1Z559 Whole genome shotgun sequence assembly, scaffold_4 n=1 Tax=Sordaria macrospora RepID=D1Z559_SORMA Length = 357 Score = 102 bits (253), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 98/339 (28%), Positives = 150/339 (44%), Gaps = 50/339 (14%) Query: 16 ILLLDGAMATELE---ARGCNLADSLWSAKVLVENPE-LIREVHLDYYRAGAQCAITASY 71 + +LDG + T LE + LWS+ +LV E + + H + +AGA TA+Y Sbjct: 7 VQILDGGLGTTLEDLHGITFSFETPLWSSHLLVSGEEDKLLDCHEAFQKAGANIISTATY 66 Query: 72 QATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLAD 131 Q + GFAA ++ + IGK R LA N VA ++GPYGA + Sbjct: 67 QTSINGFAATKAPKSGAPDGIGKEGIPHFLNRAVVLAANAAGKEGKVALALGPYGATMIP 126 Query: 132 GSEYRGDY---HCSVEAFQAFHRPRVEALLDAGA---DLLACETLPNFSEIEALAELLTA 185 +EY G Y H A + +H+ R++ D + +A ET+P EI A+ LL+ Sbjct: 127 STEYSGKYDPGHQDARALEEWHKKRLDLFKDVNTNQVNYIAFETVPRLDEIVAIRNLLST 186 Query: 186 YP-----RAR-AWF-SFTLRDSEHLSDGTPLRDVV----ALLAGYPQVVALGINCIALEN 234 R R W S D E L DG+ + +VV G +GINC +E Sbjct: 187 DKIPTSLRGRPVWISSLYPNDDEKLPDGSTVEEVVRAALTRREGLETPWGIGINCTKVEK 246 Query: 235 T-------TAALQ----HLHGLTVLPLVVYPN--SGEHYDAVSKTWH-HHGE-------- 272 AALQ + + LV+YP+ +GE Y+ ++KTW G+ Sbjct: 247 LDSLVRRYEAALQSCIDNGEPMDWPSLVLYPDGTNGEVYNTINKTWELPPGQKQPEAPWE 306 Query: 273 ----HCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 + A +W++ ++GGCC+T+P I L+ Sbjct: 307 VILTNVVGAARQRGKWKSI---IVGGCCKTSPELIRKLQ 342 >UniRef50_A9GUQ7 Putative homocysteine S-methyltransferase family protein n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9GUQ7_SORC5 Length = 309 Score = 100 bits (249), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 100/300 (33%), Positives = 133/300 (44%), Gaps = 33/300 (11%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVE--NPELIREVHLDYYRAGAQCAITASYQA 73 I++LDG + TEL ARG LWSA L++ +++R +H DY RAGA +++ Sbjct: 20 IVVLDGPLGTELAARGVETPAPLWSAAALLDARGRDVVRAIHRDYARAGATVHTANTFRT 79 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 R A L ++V LAR EA E P+ VAGS+ P L D Sbjct: 80 R------RRQAGAAWAELASRAVSLAR---EAVRGEGPR---HRVAGSIAP----LEDC- 122 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE-IEALAELLTAYPRARAW 192 YR D +A Q HR AL AG DLL CET P+ E + AL E + AW Sbjct: 123 -YRPDLS-PADARQE-HRELARALASAGVDLLLCETFPHVGEALVALEEAVATG--VEAW 177 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVV 252 SFT L + A L +NC T A ++ L V P Sbjct: 178 VSFTAGPGSDLLSPEDVGRAAREAAARGASAVL-VNCTPATRTLAHIERLAACGV-PFGA 235 Query: 253 YPNSGEHYDAVSKTW----HHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 Y N+G + + W G A+ A+ +W AGA ++GGCC T P IAAL+A Sbjct: 236 YANAGAEAEGLG--WGVGVDQRGSAAARYAELARRWLEAGATIVGGCCGTGPGHIAALRA 293 >UniRef50_C1F3L2 Methylenetetrahydrofolate reductase n=2 Tax=Bacteria RepID=C1F3L2_ACIC5 Length = 636 Score = 100 bits (248), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 93/307 (30%), Positives = 141/307 (45%), Gaps = 17/307 (5%) Query: 4 NNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGA 63 NN L+ + + +L DGAM T L ARG + ++ + PEL+R VH DY +AGA Sbjct: 2 NNRLKEIFGDRPVLC-DGAMGTSLYARGIFINRCF--DELNLSQPELVRSVHEDYLQAGA 58 Query: 64 QCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVG 123 + T ++ A GL + ++ I ++ +A A LA+ QAG VAGSVG Sbjct: 59 EIIETNTFGANAIRLRRYGLQDKVAE--INQAGARIARAAVAQLADK-QAGNAWVAGSVG 115 Query: 124 PYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 P G L E G ++ QA ++E L+ G DLL ET+P +E + Sbjct: 116 PLGVRL----EPLG--KVGLDEAQAIFAEQIEGLVAGGVDLLVIETMPALNEAQQAIRAA 169 Query: 184 TAY-PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 A P T+ + DGT A LAG+ A+G+NC A++ Sbjct: 170 RAVAPELPVIAMVTVDEESRCLDGTAPEVAAARLAGW-GADAVGVNCSTGPAAVLTAIEC 228 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 + T LPL PN+G + + +A + ++ +G + +GGCC TTP Sbjct: 229 MAEATDLPLAAMPNAGMPRAVDGRNIYLCSPE--YMASFARKFHKSGVQFLGGCCGTTPN 286 Query: 302 DIAALKA 308 I A+K+ Sbjct: 287 HIRAMKS 293 >UniRef50_UPI0001AEC485 homocysteine S-methyltransferase family protein n=1 Tax=Alteromonas macleodii ATCC 27126 RepID=UPI0001AEC485 Length = 308 Score = 99.4 bits (246), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 89/317 (28%), Positives = 130/317 (41%), Gaps = 52/317 (16%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 DIL+LDG M EL+ G WSA L++ PEL+ +VH + AGA T +Y Sbjct: 10 DILILDGGMGRELKKTGAPFKQPEWSALALMQTPELVSDVHKRFLEAGACVITTNAYALV 69 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP-YGAYLADGS 133 P E Q+ L + ELAR A A ++ VAGSV P +G+Y D Sbjct: 70 PFHIGENTFRE-QAFTLAQNAAELARGAVNALKSDGDN--KRFVAGSVPPAFGSYRPD-- 124 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALL-------DAGADLLACETLPNFSEIEALAELLTAY 186 F RV +L + D+ ET + E EA+ L+ Y Sbjct: 125 --------------LFDATRVADILTPLIKAQEPYVDVWLIETASSVEEAEAVVSLIKQY 170 Query: 187 PRARAWFSFTLRDSE------HLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQ 240 W SF++ + E L G PL ++ +L+ +V ++ NC E A+ Sbjct: 171 SSLPLWLSFSVSNRETSNEPVTLRSGEPLSEIAPILS---EVQSVLFNCSQPEEMEDAIS 227 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHC-----------AQLADYLPQWQAAGA 289 L N G + ++ S+ H + A+ +Y+ W AAGA Sbjct: 228 ITRSLD-----TSINIGAYANSFSERKRTHAANALLSEIRDDITPARYVEYVKTWVAAGA 282 Query: 290 RLIGGCCRTTPADIAAL 306 +IGGCC P I A+ Sbjct: 283 TIIGGCCGIGPEHIKAI 299 >UniRef50_A3ERA3 5-methyltetrahydrofolate--homocysteine methyltransferase n=3 Tax=Leptospirillum RepID=A3ERA3_9BACT Length = 815 Score = 99.4 bits (246), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 92/304 (30%), Positives = 148/304 (48%), Gaps = 36/304 (11%) Query: 7 LRALLD--KQDILLLDGAMATELEARGC--NLADSLWSAKVLVENPELIREVHLDYYRAG 62 ++ LL+ K +ILLLDG+M L++RG A LW+ +E P+ I++VH +Y AG Sbjct: 1 MKPLLERLKNEILLLDGSMGALLQSRGLPPGYAPDLWN----LERPQDIQQVHSEYVEAG 56 Query: 63 AQCAITASYQATPAGFAARGLD-EAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGS 121 + +T ++ ++ R D E Q + + VE+AR+A G VAG Sbjct: 57 SDIILTNTFGSS--RLRLREYDAEGQIREINEAGVEMARRASR---------GKAYVAGD 105 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA-LA 180 +GP G +A + D +A F+ + LL+AG DL+A ET+ + E+ A L Sbjct: 106 IGPSGTTIAPFGDLPFD-----DAIGIFYE-QARILLEAGVDLIAIETMFDIQEMRAALI 159 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSD-GTPLRDVVALLAGYPQVVALGINC-IALENTTAA 238 + A + +++ ++D G+ ++L G+ V LG+NC + E Sbjct: 160 GVREAVGNRIPVMALMTFNNDGITDSGSDPETAASVLEGF-GVEILGLNCSVGPEAMVPV 218 Query: 239 LQHLHGLTVLPLVVYPNSG--EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCC 296 ++ L T + V PN+G H D + + E A+ A PQ+ AGA +IGGCC Sbjct: 219 VRRLGQTTSTFIAVEPNAGLPVHRDG-HTVYPANAEDVARFA---PQFVEAGANIIGGCC 274 Query: 297 RTTP 300 TTP Sbjct: 275 GTTP 278 >UniRef50_B0DTQ2 Predicted protein n=1 Tax=Laccaria bicolor S238N-H82 RepID=B0DTQ2_LACBS Length = 418 Score = 99.0 bits (245), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 100/381 (26%), Positives = 154/381 (40%), Gaps = 77/381 (20%) Query: 3 QNNPLRALLDKQDILLLDGAMATELE-ARGCNLADSLWSAKVLVENPELIREVHLDYYRA 61 +N A++D + + T LE ++ LWSA + +PE + HL + A Sbjct: 31 RNARFDAMIDAMNAVRRIWMQGTTLEDVFHKSIKTPLWSATLTETDPETVIAAHLAFLEA 90 Query: 62 GAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQ--AGTLLVA 119 G+ +T++YQ F G EA + L+ KSVELA +A+ +LA+NP A + +A Sbjct: 91 GSLVIMTSTYQRAFETFERAGYGEADAVTLMNKSVELASEAKSRFLAQNPSITATYIKIA 150 Query: 120 GSVGPYGAYLADGSEYRGDY-----------------------------HCSVEAFQAFH 150 ++GP+GA L E+ G Y +V++ +FH Sbjct: 151 LALGPFGATLTTAQEFSGYYPPPYGPQEFTPDLDGTNTNAFSAEESEAEAVAVDSLASFH 210 Query: 151 RPRVEALLDAGA----DLLACETLPNFSEIEALAE---LLTAYPRARAWFSFTLRDSEHL 203 R+ + + D++ ET+P EI A+ +L + W + D L Sbjct: 211 LRRLRVFCNHPSWDLVDVIVFETVPLVREIAAIRRAVGMLPEFAMKSWWVATVWLDGVFL 270 Query: 204 SDGTP------LRDVV-ALL----AGYPQVVALGINCIALENTTAALQ-HLHGLTVL--- 248 + P DVV ALL P +G+NC +E +Q H L Sbjct: 271 QESVPGGERLLAADVVDALLRDASPANPVPTGIGVNCTQIEYYPEIIQAHRIAFNALLLS 330 Query: 249 ----------PLVVYPNSGEHYDAVSKTW------HHHGEHCAQ-------LADYLPQWQ 285 LVVY N G YD ++ W H G AQ LA ++ Sbjct: 331 QVGDSKFARPRLVVYSNGGVKYDPIAHVWLDSGVAHRGGTGKAQWVKELVSLAKEEGKFG 390 Query: 286 AAGARLIGGCCRTTPADIAAL 306 + ++GGCC+T P DI AL Sbjct: 391 SWAGIVVGGCCKTAPDDIHAL 411 >UniRef50_B2AAZ0 Predicted CDS Pa_1_5620 n=2 Tax=Sordariales RepID=B2AAZ0_PODAN Length = 371 Score = 98.6 bits (244), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 102/372 (27%), Positives = 151/372 (40%), Gaps = 81/372 (21%) Query: 4 NNPLRALLDKQDILLLDGAMATELEA-RGCNLADS--LWSAKVLVENPELIREVHLDYYR 60 P+ + I LDG + T LE G ++S LWS+ +L+ + + + + + + + Sbjct: 6 QTPIMEGRKPRTIKFLDGGLGTTLETIHGVKFSESTPLWSSHLLLTDLQTLADCQMSFAK 65 Query: 61 AGAQCAITASYQATPAGFA-------ARGLDEAQSKALIGKSVELARKAREAYLAENPQA 113 AGA TA+YQA+ GF G+ + +V +AR+A A Sbjct: 66 AGADVITTATYQASINGFKNTKTENWPNGVPLPNIGHFLKDAVSIARRA----------A 115 Query: 114 GTL--LVAGSVGPYGAYLADGSEYRGDYHCS-----VEAFQAFHRPRVEALLDA-----G 161 G + VA S+GPYGA + +EY G Y V+ +H R + Sbjct: 116 GKVGGRVALSLGPYGATMIPSTEYTGHYDIEPSQDIVDKLFHWHSERYNLYVQVPNLLFD 175 Query: 162 ADLLACETLPNFSEIEALAELLTA-------------YPRARAWFSFTL-RDSEHLSDGT 207 +A ET+P EI A+ L A Y W S D + + DGT Sbjct: 176 VSYIAFETIPRLDEILAIRRFLNADISGGVKLGPREFYHDIPVWISVLFPSDDDKMPDGT 235 Query: 208 PLRDVVALL------AGYPQVVALGINCIALENT-------TAALQHLHGLTVLP----L 250 + D VA + + PQ V GINC + T A++ L + L Sbjct: 236 SVEDAVAAMISKEFGSKTPQFV--GINCTQVSKLEGLVRQFTKAVEKLVATGAVEKWPGL 293 Query: 251 VVYPNS---GEHYDAVSKTWHHHGEHCA----------QLADYLPQWQAAG---ARLIGG 294 V+YP+ GE Y+ +K W GE QLA + + G + LIGG Sbjct: 294 VLYPDGTKVGERYNTATKEWEISGEGSKKTPEDVSWERQLAMVVKEAYDTGGWSSFLIGG 353 Query: 295 CCRTTPADIAAL 306 CCRTTP +I L Sbjct: 354 CCRTTPENIQRL 365 >UniRef50_Q2S678 Vitamin B12-dependent methionine synthase family protein n=1 Tax=Salinibacter ruber DSM 13855 RepID=Q2S678_SALRD Length = 320 Score = 98.2 bits (243), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 98/313 (31%), Positives = 138/313 (44%), Gaps = 41/313 (13%) Query: 17 LLLDGAMATELEARGC-NLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 +LLDG + EL RG + SLWSA L E P+L++EVH +Y RAGA T +Y P Sbjct: 13 VLLDGGLGQELIRRGMPSTEPSLWSANALTEAPDLVQEVHEEYLRAGADVITTNTYATPP 72 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY-GAYLADGSE 134 + GLD +++AL ++ LA +AR A L+AGS+ P G+Y D Sbjct: 73 ERLSEAGLD-GRAEALNREAGRLAERARAAV------GRDALIAGSLPPIRGSYRPDLVG 125 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETL--PNFSEIEALAELLTAYPRARAW 192 G+ + P V DL CET+ P + A T P Sbjct: 126 EAGEIEPQYREQAGYLAPHV--------DLFLCETMSTPGEARAAARGAASTGLP---VL 174 Query: 193 FSFTLRDSEHLSDGTP-------LRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL 245 S+T+ D D P L + V L+G P V + +NC E+ +AA+ L L Sbjct: 175 VSYTIADPSSPEDAEPRLHNGESLEEAVEALSGLP-VAGVLLNCSHPESISAAVPVLRQL 233 Query: 246 TVLPLVVYPNSGEHY--------DAV-SKTWHHHGEHCAQLA--DYLPQWQAAGARLIGG 294 T + Y N+ H DA+ S E A A ++ W +AGA ++GG Sbjct: 234 TDRAVGAYANAFTHIPDGFDERADALDSDARPDRREDLAPEAYGRHVEDWLSAGANIVGG 293 Query: 295 CCRTTPADIAALK 307 CC P IA L+ Sbjct: 294 CCEVGPGHIAHLR 306 >UniRef50_B9XKW8 Methylenetetrahydrofolate reductase n=1 Tax=bacterium Ellin514 RepID=B9XKW8_9BACT Length = 624 Score = 97.4 bits (241), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 92/299 (30%), Positives = 136/299 (45%), Gaps = 32/299 (10%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 Q +LL DGA+ T L RG L S + + ++PE++ ++H DY AGA T ++ Sbjct: 9 NQGVLLGDGAIGTLLYQRGQPLNASYDALNL--QHPEIVSQLHRDYLDAGAHLIETNTFG 66 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A GL + K+V++ + + L G VAGSVGP A D Sbjct: 67 ANRIKLEKFGLAQ--------KTVDINKHGAQLALEVACGRGAF-VAGSVGPLSA---DP 114 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 S S + + +R ++EAL+ G D L ET E+ + + + Sbjct: 115 SS------LSTQTKDSAYREQLEALVSEGVDALFLETFNRLDELAFVLRIARSLGNTPII 168 Query: 193 FSFTLRDSEHLSDGTPLRDVVALL--AGYPQVVALGINCIALENTTAALQHLHGLTVLP- 249 S + D H +DG + + + L AG V G+NC T A + L L V P Sbjct: 169 ASLSFGDDGHTADGLRINEAFSRLKEAGADVV---GLNCHF--GPTIAEKLLEELIVRPG 223 Query: 250 --LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 + +YPN+G Y + +H + AD+ P+ A GARLIGGCC TTP IAA+ Sbjct: 224 DLISIYPNAGRPYFYEGRYIYHSTP--SYFADFAPKLIAQGARLIGGCCGTTPETIAAM 280 >UniRef50_B9L045 Methylenetetrahydrofolate reductase n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=B9L045_THERP Length = 624 Score = 97.1 bits (240), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 99/312 (31%), Positives = 150/312 (48%), Gaps = 32/312 (10%) Query: 4 NNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGA 63 +P R ++ Q +LL DGAM T+L RG L SA + +P+L+ E+H Y AGA Sbjct: 2 KHPFRDRIE-QGVLLADGAMGTQLYERGIRLDRCFESANL--THPQLVVEIHRAYILAGA 58 Query: 64 QCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVG 123 + T ++ A A G+ E + + + ++V AR+ARE + P + +AG++G Sbjct: 59 ELIETNTFGANRFKLEAYGMAE-RVREINRRAVRHAREARE--ICGVP----VFIAGAIG 111 Query: 124 PYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEI-EAL--A 180 P G LA + E+ + R ++EALL+ G DLL ET+ +EI EA+ A Sbjct: 112 PSGRLLAPVGT------VAPESLRPVFREQIEALLEGGVDLLIFETMSQLAEIREAIMAA 165 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQ 240 + P A +F D ++ P +VVA LA V +G+NC T L+ Sbjct: 166 REVCDLPIV-AQMTFAA-DGRTIAGHGP-EEVVAALAEL-GVDVIGVNCSVGPRPT--LE 219 Query: 241 HLHGLTV-----LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGC 295 L + L PN+G + V +G AD+ + + G RLIGGC Sbjct: 220 VLRAMIAANRWGTALSAMPNAG--WPTVVGHRVIYGASPEYFADFAREAASLGVRLIGGC 277 Query: 296 CRTTPADIAALK 307 C TTP IAA++ Sbjct: 278 CGTTPEHIAAMR 289 >UniRef50_B4RRL7 Homocysteine S-methyltransferase family protein n=1 Tax=Alteromonas macleodii 'Deep ecotype' RepID=B4RRL7_ALTMD Length = 305 Score = 95.9 bits (237), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 90/318 (28%), Positives = 132/318 (41%), Gaps = 56/318 (17%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 I +LDG M EL+ G WSA L+++PEL+ +VH + AGA T +Y P Sbjct: 8 IQILDGGMGRELKKIGAPFRQPEWSALALMQSPELVSDVHTHFLNAGATVITTNTYALVP 67 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP-YGAYLADGSE 134 + +E Q+ L + +LAR A A ++ Q G L VAG + P +G+Y D Sbjct: 68 FHIGEQTFNE-QAFKLAETAAKLARDAVNAQ--QDKQEGNLSVAGCIPPAFGSYRPD--- 121 Query: 135 YRGDYHCSVEAFQAFHRPRVE----ALLDAGA---DLLACETLPNFSEIEALAELLTAYP 187 F RV L++A A D+ ET + E EA+ L+ Sbjct: 122 -------------LFDASRVSEILMPLIEAQAPYIDVWLIETASSIEEAEAVVSLIKTLS 168 Query: 188 RARAWFSFTLRDSEH------LSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQH 241 W SF+L + L G PL +V +L +V+ NC E +A+ Sbjct: 169 SRPIWLSFSLHNRASTDEPVTLRSGEPLEKIVPVLRDVERVL---FNCSQPEEMESAITI 225 Query: 242 LHGLTVLPLVVYPN--SGEHYDAVSKTWHHHGEHC-----------AQLADYLPQWQAAG 288 L PN G + ++ S+ H + A+ DY+ W AAG Sbjct: 226 TRKLN-------PNIAIGAYANSFSERKRSHQANALLSELRDDVTPARYLDYVKSWIAAG 278 Query: 289 ARLIGGCCRTTPADIAAL 306 A +GGCC P I A+ Sbjct: 279 ASTVGGCCGIGPEHIKAI 296 >UniRef50_A1SWN6 Homocysteine S-methyltransferase n=1 Tax=Psychromonas ingrahamii 37 RepID=A1SWN6_PSYIN Length = 310 Score = 95.5 bits (236), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 93/313 (29%), Positives = 138/313 (44%), Gaps = 46/313 (14%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 ++LDG M EL+ G WSA+ L+E+P I EVH + AGA+ T +Y P Sbjct: 17 IILDGGMGRELKRIGAPFQQPEWSAQALIESPHFISEVHKSFIEAGAEVITTNTYALVPF 76 Query: 77 GFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYR 136 + +E Q LI + LAR+ + EN +LVAG + P GS YR Sbjct: 77 HIGEKRFNE-QGADLIKLAARLAREC----VKEN---SAVLVAGCIPP-----VLGS-YR 122 Query: 137 GDYHCSVEAFQAFHRPRVEALL---DAGADLLACETLPNFSEIEALAELLTAYPRARAWF 193 D +A +P +E L+ +A D+ ET+ + +E A+ + T W Sbjct: 123 PDLFSVEKA-----KPVLELLIKNQEADVDIWLAETISSIAE-AAMIKARTVVTNKPTWI 176 Query: 194 SFTLRD----SEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAAL----QHLHGL 245 +FT++D L G + D V+ +AG V A+ NC +E AL Q L Sbjct: 177 AFTIKDEITTEPALRSGESVYDAVSQIAGQ-NVSAILFNCSGVEVMETALITAKQALLDK 235 Query: 246 TV---LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLP---------QWQAAGARLIG 293 + + L VY N+ + + HG + + D +P W AGA +IG Sbjct: 236 EIEDQVQLGVYANNFPPIGELHQANQDHG--VSGIRDDVPPEKYHEFGLSWINAGASIIG 293 Query: 294 GCCRTTPADIAAL 306 GCC +PA I L Sbjct: 294 GCCGVSPAHIKKL 306 >UniRef50_B8M2P0 Homocysteine S-methyltransferase, putative n=1 Tax=Talaromyces stipitatus ATCC 10500 RepID=B8M2P0_TALSN Length = 369 Score = 95.1 bits (235), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 93/352 (26%), Positives = 153/352 (43%), Gaps = 53/352 (15%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLA----DSLWSAKVLVENPELIREVHLDYYRAG 62 + L++ ILLLDG + T LEA N+ LWS+ +L+++P ++ H + AG Sbjct: 15 ISKLVNTMQILLLDGGLGTTLEASPFNVQFTPEKPLWSSHLLIDSPSTLQAAHHAFCDAG 74 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKA--LIGKSVELARKAREAYLAENPQAGTLLVAG 120 A +TA+YQ + GF A + ++ L R A + + ++ VA Sbjct: 75 ADIILTATYQTSTEGFTRTNSSYTARDAAQYMRSAIPLVRSAVSSTADDKKRS----VAL 130 Query: 121 SVGPYGAYLADGS-EYRGDYHCSVE---AFQAFHRPRVEALLDA------GADLLACETL 170 S+GPYGA ++ S EY G Y ++ A + +H R++ ++ D +A ETL Sbjct: 131 SLGPYGATMSPVSAEYTGIYPPEMDGENALREWHTQRLKIFTESEDESWDQVDYIAFETL 190 Query: 171 PNFSEIEALAELLTAY-----PRARAWFSFTLRDSEHLSDGTP---LRDVVALLAGYPQV 222 E+ A+ + + W+ + E + + +R V G P+ Sbjct: 191 RRADEVCAVRGAVCDVVGRDSTSKKPWWICGVFPGEQVDEEEIRQWVRAAVGNHPGLPRP 250 Query: 223 VALGINCIALENTTAALQHLHG--------------LTVLP-LVVYPN--SGEHYDAVSK 265 +G+NC ++ A + + + P LV+YP+ GE YD V+K Sbjct: 251 WGIGLNCTRIDRVEAIVSIMRDEVRRLLDQAQIDEWASSKPWLVLYPDGTKGEKYDPVTK 310 Query: 266 TWHHHGEHCAQ------LADYLPQWQAA--GARLIGGCCRTTPADIAALKAR 309 TW + D + A G ++GGCCR PADIAAL+ R Sbjct: 311 TWVQSVTDTVKRPWDEIFWDIIQHQSKAEWGGIVVGGCCRAGPADIAALRRR 362 >UniRef50_D2R929 Homocysteine S-methyltransferase n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2R929_9PLAN Length = 293 Score = 95.1 bits (235), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 94/297 (31%), Positives = 136/297 (45%), Gaps = 29/297 (9%) Query: 20 DGAMATELEARGCNLADSLWSAKVLVENPEL--IREVHLDYYRAGAQCAITASYQATPAG 77 DGA TEL RG + +WSA L + L +R++HLDY +AGA +++ Sbjct: 16 DGATGTELNRRGLDTGLPMWSANALTTDTGLNVLRQIHLDYLQAGADILTANTFRTHRRA 75 Query: 78 FAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYRG 137 A++ ++ L ++V A++A +AE QA VAGSV P L D YR Sbjct: 76 LASK---VHAARELTMRAVATAQEA----IAEFGQAAQ--VAGSVSP----LEDC--YRP 120 Query: 138 DYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL--LTAYPRARAWFSF 195 D + +A H R++ L+DAG DLL ET+ + E A+L +T P SF Sbjct: 121 DLVPPDDMCRAEHSERIQHLVDAGVDLLLIETMSSIREAVIAAKLATITGLP---TLVSF 177 Query: 196 TLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLT--VLPLVVY 253 + G P+ LL V ALG+NC L L + PL+ Y Sbjct: 178 VCDGEGRILSGEPVAVAAELLLPL-GVKALGVNCGPAHTLAKPLVELRRICGPDFPLIAY 236 Query: 254 PNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKARS 310 N G Y ++ W + + YL + A+++GGCC TTPA I L+ RS Sbjct: 237 GNIG--YADEAQGWINTDAESPE--SYLHHAETWPAQILGGCCGTTPAHIRRLRVRS 289 >UniRef50_A4XIN4 Homocysteine S-methyltransferase n=1 Tax=Caldicellulosiruptor saccharolyticus DSM 8903 RepID=A4XIN4_CALS8 Length = 411 Score = 95.1 bits (235), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 85/305 (27%), Positives = 135/305 (44%), Gaps = 38/305 (12%) Query: 14 QDILLLDGAMATELEARGC--NLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 + +L+ DGAM T+L G N LWS V PE+I ++H DY+ AG+ C T ++ Sbjct: 8 KKVLVFDGAMGTQLIQNGLKENECPDLWS----VTRPEVIAKIHRDYFEAGSDCVETNTF 63 Query: 72 QATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLAD 131 A GL E + + + ++ LA+ + Y V SVGP G + Sbjct: 64 GANREKLKKYGL-ENEVEKINKAAILLAKDVAKEYGG--------YVGLSVGPTGRLMRP 114 Query: 132 GSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRAR- 190 + D EA F+ ++ A ++AGAD ++ ET+ + E +A AY RA+ Sbjct: 115 SGDLDFD-----EAESVFYE-QILAGIEAGADFISIETMSDIKEAKA---AFLAYKRAKE 165 Query: 191 -------AWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHL 242 S T +++ L GTP +V A + +G NC + ++ + Sbjct: 166 NANKDVACLVSLTFEENKRLLMGTP-PEVAAYFFSFIGADLVGANCSGGAKQLLDVIKSM 224 Query: 243 HGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHC-AQLADYLPQWQAAGARLIGGCCRTTPA 301 +G + +PL PN+G K + E C A ++ +G RL GGCC T P Sbjct: 225 NGFSFVPLSTKPNAGLPKMIDGKVVY---EDCIADFESSTEEFIQSGVRLYGGCCGTNPE 281 Query: 302 DIAAL 306 I A+ Sbjct: 282 YIKAI 286 >UniRef50_B6AUX0 Homocysteine S-methyltransferase n=1 Tax=Rhodobacterales bacterium HTCC2083 RepID=B6AUX0_9RHOB Length = 298 Score = 94.0 bits (232), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 91/312 (29%), Positives = 131/312 (41%), Gaps = 42/312 (13%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASY--- 71 D++L DG M EL R + LWS +V+++ P L+ +V D++ AG+ A SY Sbjct: 3 DVMLFDGGMGQELVHRAGDKPTPLWSTQVMMDKPGLVADVSRDFFAAGSTVATLNSYAIQ 62 Query: 72 --QATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYL 129 + P G + D S AL ++ ++A A G+ +AGS+GP A Sbjct: 63 RDRLVPVGIEDQ-FDTLHSMAL--------KEGQDAVAAH----GSGRLAGSMGPLAA-- 107 Query: 130 ADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA-LAELLTAYPR 188 YR D H S + + + + DL+ CET+ + LA TA Sbjct: 108 ----SYRPDIHPSADIAVPLYTEVAQKFV-GNVDLIVCETVVSLEHTRCILAGAKTANLP 162 Query: 189 ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVL 248 FS + D L G P+ + A +A VVA+ NC A E AL L T L Sbjct: 163 IYCAFSVSDEDGSKLRSGEPVLE-AAQIAKDMGVVAVMANCSAPEVIPTALNEL-AKTSL 220 Query: 249 PLVVYPNSGEHYDAVSKTWHHHGEHCAQL-----------ADYLPQWQAAGARLIGGCCR 297 P Y N + +S + L AD++ W GA LIGGCC Sbjct: 221 PFGAYANG---FTKISDGFLKDRPTVDALTLRKDFSPDLYADHVMAWVDQGATLIGGCCE 277 Query: 298 TTPADIAALKAR 309 +PA IA + R Sbjct: 278 VSPAHIAEIAKR 289 >UniRef50_D1B7X8 Homocysteine S-methyltransferase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B7X8_THEAS Length = 816 Score = 93.6 bits (231), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 100/317 (31%), Positives = 146/317 (46%), Gaps = 54/317 (17%) Query: 7 LRALLDK-QDILLLDGAMATELEARGCNLADSLWSAKVLVEN-----PELIREVHLDYYR 60 +R+LL + + L++DG M T+L RG W +L E P+ +REVH Y Sbjct: 8 VRSLLGEVRSPLVMDGGMGTQLAERG-------WHPPMLPEEMCLHMPQAVREVHESYVE 60 Query: 61 AGAQCAITASYQATPAGFAARGLDE-AQSKALIGKSVELARKAREAYLAENPQAGTLLVA 119 +GA T S+ + + RGL A+ AL +S ++AR+A AG LVA Sbjct: 61 SGAAVLETNSFGGSVRKLSMRGLGHLAEELAL--RSAQIARQA----------AGDALVA 108 Query: 120 GSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEAL 179 GSVGP G LA E + +V++F+ P+V L+ GADL+ ET+ + E A Sbjct: 109 GSVGPTGEMLAPLGEM--SFEEAVKSFE----PQVRGLIRGGADLILIETMLDLKEAAAA 162 Query: 180 AELLTAYPRARAWFSFTL-----RDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALE 233 A R F F + RD ++ TP + A A + +G NC + Sbjct: 163 V---EAVKRVDPLFPFVVSFTFDRDGRTVTGTTP--EAAACWAQAVGALGVGANCGLGPR 217 Query: 234 NTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHG--EHCAQLADYLPQWQAAGARL 291 ++ L + LP+ VYPN+G V + G E + + L AGA + Sbjct: 218 GYVPVVRRLAEASPLPVWVYPNAG-----VPSAGDYLGPDEFVGECEELL----KAGASV 268 Query: 292 IGGCCRTTPADIAALKA 308 IGGCC TTP + AL A Sbjct: 269 IGGCCGTTPDHVRALAA 285 >UniRef50_B5YB64 5-methyltetrahydrofolate-homocysteine methyltransferase n=1 Tax=Dictyoglomus thermophilum H-6-12 RepID=B5YB64_DICT6 Length = 289 Score = 93.6 bits (231), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 89/310 (28%), Positives = 130/310 (41%), Gaps = 52/310 (16%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 + L DGAM TEL+ RG L + +ENP L+ EVH DY +AG+ T ++ Sbjct: 9 EFLFFDGAMGTELQRRG--LPPGTPPEVLNLENPTLVEEVHRDYIKAGSMVIETNTFGGN 66 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 GLD + K + K VE+A+KA E G +L+AGSVGP G + E Sbjct: 67 RIRLKRAGLD-GKIKEINEKGVEIAKKASE---------GKVLIAGSVGPLGELI----E 112 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW-- 192 GD S E + ++E L+ +G DL+ ET+ +L E L A A+ + Sbjct: 113 PYGD--ISEEEAEEVFTEQIEILVKSGVDLILIETMI------SLNEALIALKSAKKFDI 164 Query: 193 -------FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVA---LGINC-IALENTTAALQH 241 F +T R TP D V + +G NC E+ Sbjct: 165 PVGVTMSFEWTERGGR-----TPFGDEVEYSIKTLEENGADFVGANCGRGFEDMIKIAPI 219 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHH----HGEHCAQLADYLPQWQAAGARLIGGCCR 297 + T LP+++ PN+G W + + E + ++ + IGGCC Sbjct: 220 IRKATTLPVLIQPNAG------IPQWENGKLTYPETPDKFKIFVEEMLKLNINFIGGCCG 273 Query: 298 TTPADIAALK 307 TTP I K Sbjct: 274 TTPNHIEVFK 283 >UniRef50_C6DY72 Homocysteine S-methyltransferase n=10 Tax=Desulfuromonadales RepID=C6DY72_GEOSM Length = 813 Score = 92.4 bits (228), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 95/304 (31%), Positives = 140/304 (46%), Gaps = 37/304 (12%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K+ +L+LDGAM T L+ RG S ++ + E++ VH Y AGA +T ++ Sbjct: 10 KERVLVLDGAMGTMLQERGLKPGQS--PEEMNLTAAEVVAGVHQAYLDAGADIIVTNTFG 67 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARK--AREAYLAENPQAGTLLVAGSVGPYGAYLA 130 T A GL + Q + ++V +AR+ +AY VAGS+GP G +L Sbjct: 68 GTKAKLEHYGLGD-QVARINAEAVRIAREVAGEKAY-----------VAGSIGPTGRFL- 114 Query: 131 DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA----LAELLTAY 186 E GD EA F R + +AL+DAG DL++ ET + EI A + E+ Sbjct: 115 ---EPVGDMSFD-EAVSLF-REQAQALVDAGCDLISFETFLDIKEIRAGVIAVREISQEI 169 Query: 187 PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGL 245 P A +F + L GTP + L + +G NC + + L + + Sbjct: 170 P-VIAMLTFEEKGISVL--GTPPQAAAITLEAVGATI-VGSNCGLGPDGIYQILSDMRDV 225 Query: 246 TVLPLVVYPNSGEHY--DAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADI 303 T LPL+ N+G D V+ E A Y + G R+IGGCC TTPA I Sbjct: 226 TALPLISQANAGLPILKDGVTIFPATPDEMTA----YHDRLIELGVRIIGGCCGTTPAHI 281 Query: 304 AALK 307 +A+K Sbjct: 282 SAIK 285 >UniRef50_Q01QP4 Methylenetetrahydrofolate reductase n=2 Tax=Acidobacteria RepID=Q01QP4_SOLUE Length = 622 Score = 92.0 bits (227), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 87/301 (28%), Positives = 141/301 (46%), Gaps = 30/301 (9%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 +++ DGAM T L +RG + ++ + +++R++H +Y +AGA+ T ++ AT Sbjct: 20 VIVADGAMGTMLYSRGVFINRCF--DELNLSAADMVRQIHQEYVKAGAEILETNTFGATR 77 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 A G E + +A+ V LAR+A G+ VAG+VGP + E Sbjct: 78 QRLGAFGFAE-KLQAINHAGVRLAREAAN---------GSAYVAGAVGPLNVRI----EP 123 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 G + EA AF R +++ALL+AG DLL ET N E+ + Y +R Sbjct: 124 LGPTSFA-EARAAF-REQIDALLEAGVDLLIFETFGNLDELR--EAVYAGYDASRGEVPM 179 Query: 196 ----TLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPL 250 T+ D HL GT + +P V +G+NC + + T ++ + PL Sbjct: 180 IAQVTIDDFGHLPGGTDTETFTREMNNWP-VDVIGLNCSVGPKATLETVERMMEFATKPL 238 Query: 251 VVYPNSGEHYDAVSKTWHH-HGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKAR 309 PN+G + + E+ +Q A L W AG ++IGGCC TTP I +++ Sbjct: 239 SAMPNAGLPMRVEGRNIYLCSPEYMSQYARRL-LW--AGVKVIGGCCGTTPDHIKLIRSE 295 Query: 310 S 310 + Sbjct: 296 T 296 >UniRef50_C8W2L3 Homocysteine S-methyltransferase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8W2L3_DESAS Length = 801 Score = 92.0 bits (227), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 89/306 (29%), Positives = 134/306 (43%), Gaps = 27/306 (8%) Query: 10 LLDK--QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAI 67 +DK + IL+ DGAM T L+A G + + ++NPE ++ +H Y +AGA Sbjct: 3 FIDKLAEKILVFDGAMGTMLQAAGLRAGE--CPELINLKNPETVKNIHRQYVKAGADIVE 60 Query: 68 TASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGA 127 T ++ + GL + K E+ A LA+ G LVA SVGP G Sbjct: 61 TNTFGGSRLKLLEYGLAD--------KVAEI--NASAVRLAKESADGQALVALSVGPTGK 110 Query: 128 YLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY- 186 + D EA F ++ A AGAD++ ET+ + EI A Sbjct: 111 LMFPNGPLTFD-----EAHHVFSE-QISAGAAAGADMICIETMSDLGEIRAALLAAKDAA 164 Query: 187 PRARAWFSFTLRDSEHLSDGT-PLRDVVALLAGYPQVVALGINCIALENTT-AALQHLHG 244 P S T ++ GT P+ V+ L A ++ G NC ++ + Sbjct: 165 PGVPVICSMTFEPNKRTLMGTDPVAAVITLQALGADII--GANCSGGPGELLEVIEEMAR 222 Query: 245 LTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 +PL+V PN+G +T A++ +Y+P+ AAGA LIGGCC T+P I Sbjct: 223 YARVPLIVQPNAGMPMLEGDRTVFPL--SAAEMGEYVPKLAAAGASLIGGCCGTSPEYIR 280 Query: 305 ALKARS 310 +K RS Sbjct: 281 VIKERS 286 >UniRef50_Q30ZI4 Methionine synthase (B12-dependent) n=14 Tax=Desulfovibrionales RepID=Q30ZI4_DESDG Length = 841 Score = 92.0 bits (227), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 102/325 (31%), Positives = 143/325 (44%), Gaps = 61/325 (18%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 R L +L DGAM T L+ RG L + + NP +++ VHLDY RAGA Sbjct: 35 FRRALSDDTLLFFDGAMGTMLQGRG--LPAGMSPEVFCLSNPAVLQGVHLDYARAGADVL 92 Query: 67 ITASYQAT----PAGFAARGLDEAQSKALIGKSVELARK-AREAYLAENPQAGTLLVAGS 121 T ++ T P G VE R+ AR A A T+ VAGS Sbjct: 93 TTNTFGGTRLKLPEGM---------------NVVEFNREMARAAKAAAGQAGRTVFVAGS 137 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 VGP G ++ + GD S E F R ++ L+ G DL+ ET + +E+ A+ Sbjct: 138 VGPTGHFV----KPLGDLEFS-ELVDIF-REQIRGLVQGGIDLVLAETHFDLAEVRAVVL 191 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVA-----LGINCIALENTT 236 ARA + + S DG V+L P+V +G++ IA N + Sbjct: 192 A------ARAECNLPVGVSMTFEDG------VSLTGTRPEVFVHTMQNMGVDLIA-TNCS 238 Query: 237 AALQHLHGLTV-------LPLVVYPNSGEHYDAVSKTWHHHG--EHCAQLADYLPQWQAA 287 A + + G+ +P++V PN+G T G E AQ AD++ A Sbjct: 239 AGPEQMAGVVAGLTAAGDIPVLVMPNAGLPELENGNTVFRLGPEEFAAQTADFV----RA 294 Query: 288 GARLIGGCCRTTPADIAAL--KARS 310 G R +GGCC TTP IAAL +ARS Sbjct: 295 GVRCLGGCCGTTPDHIAALAREARS 319 >UniRef50_Q15S12 Homocysteine S-methyltransferase n=1 Tax=Pseudoalteromonas atlantica T6c RepID=Q15S12_PSEA6 Length = 304 Score = 91.7 bits (226), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 89/305 (29%), Positives = 132/305 (43%), Gaps = 30/305 (9%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 I +LDG M EL R +WSA +++ PEL+R++H ++ +GA+ +Y ATP Sbjct: 12 ITILDGGMGQELLRRSSRDVTPMWSADIMLNEPELVRDLHREFINSGARVITLNTYTATP 71 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 R E Q + + R A+EA Q +++AGS+ P A Y Sbjct: 72 ----QRLKRENQFEQFVHLHDAAMRAAQEAIALT--QRDDVMIAGSLPPLVA------SY 119 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA--LAELLTAYPRARAWF 193 + S E +R V AL G+D+ CET+ + E +A A + P W Sbjct: 120 HPEVSLSFEDSLVSYRQLV-ALQSLGSDIFICETMSSICEAQAACTAAKESGKP---VWV 175 Query: 194 SFTLRDSE--HLSDGTPLRDVV-ALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPL 250 +FT+ D+E L G L+D + AL A P + L NC +L +A L + + Sbjct: 176 AFTVSDTEPDQLRSGELLKDALDALKALSPDAIML--NC-SLPEAISACWSLMQQSNAKI 232 Query: 251 VVYPNSGEHYDA------VSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 Y N DA V + Q A + W GA +IGGCC P I Sbjct: 233 GAYANGFVSIDALYPGDTVEELEMRKDMSPEQYAAHAMHWVQNGASIIGGCCEIGPDHIK 292 Query: 305 ALKAR 309 AL ++ Sbjct: 293 ALHSK 297 >UniRef50_Q4DI99 Homocysteine S-methyltransferase, putative n=2 Tax=Trypanosoma cruzi RepID=Q4DI99_TRYCR Length = 410 Score = 91.7 bits (226), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 105/394 (26%), Positives = 153/394 (38%), Gaps = 105/394 (26%) Query: 16 ILLLDGAMATELEARGCNLAD--SLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 +L+ DGAM T LE+ + A S+WS+ VL+ +L++ H Y AG +T +YQ Sbjct: 9 VLIKDGAMGTLLESWDVDYAKAGSMWSSSVLLSEMDLVKRAHRAYIDAGCDVLLTCTYQM 68 Query: 74 TPAGFAARGLDEAQSKALIGKSVELAR---------------KARE-------------A 105 G AA + + L+ ++V+ AR A+E + Sbjct: 69 HEEGCAASKVTMCE---LVDRAVQAARHTMPQRKQKGLTEESTAKERRTGGIDVFRYALS 125 Query: 106 YLAENPQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALL-DAG--- 161 + +N Q +L+AGS+GPYG+ L G EY G+Y AFH R+EA L + G Sbjct: 126 SIKDNGQERVVLLAGSLGPYGSSLPGGQEYLGEYSIHEAVINAFHARRLEAFLCNVGEKH 185 Query: 162 ---ADLLACETLPNFSEIEALA------ELLTAYPRARAWFSFTLRD------------- 199 D L ET P E + E+L P ++ + +++ Sbjct: 186 AFKVDFLLLETFPRLDEALGILSFVNQHEILRTAPFCFSFIAVPVKNPLPENADDDALDN 245 Query: 200 -------SEHLSDGTPLRDVVALLAGY--PQVVALGINCIA-LENTTAALQHLHGLTV-- 247 S L DG ++ L G +V +G NC LE + A LH Sbjct: 246 WWNAAASSIRLPDGNTFEGALSELRGNCGTALVGMGCNCSGPLEVSLVATALLHKKRQDT 305 Query: 248 ---LPLVVYPNSGEHY-DAVSKTWHHHGEHCA----QLADYLPQWQAAGARLI------- 292 L L++YPNSGE + D K + A + D G LI Sbjct: 306 EGPLVLLLYPNSGEKFTDGQWKKPLQQIQTSAAERLSMRDLKRILARGGGNLITFMKFLL 365 Query: 293 -------------------GGCCRTTPADIAALK 307 G CCR+TP DIAAL Sbjct: 366 QLLQQRPEATDWLFEIIVCGACCRSTPEDIAALN 399 >UniRef50_B8DYM9 Homocysteine S-methyltransferase n=1 Tax=Dictyoglomus turgidum DSM 6724 RepID=B8DYM9_DICTD Length = 290 Score = 91.3 bits (225), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 89/310 (28%), Positives = 133/310 (42%), Gaps = 52/310 (16%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 + L DGAM TEL+ RG L + +ENP L+ EVH DY +AG+ T ++ Sbjct: 10 EFLFFDGAMGTELQRRG--LPPGTPPEILNLENPSLVEEVHKDYIKAGSMVIETNTFGGN 67 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 GL+E + K + K VE+A+KA E G +L+AGSVGP G + E Sbjct: 68 RVRLQRAGLEE-KIKEINEKGVEIAQKASE---------GKVLIAGSVGPLGELI----E 113 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW-- 192 GD S E + F ++E L+++G DL+ ET+ +L E L A A+ + Sbjct: 114 PYGD--ISEEEAEEFFTEQIEILVNSGVDLILIETMI------SLNEALIALKSAKKFDI 165 Query: 193 -------FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVA---LGINC-IALENTTAALQH 241 F +T + TP D V + +G NC E+ Sbjct: 166 PVGVTMSFEWTEKGGR-----TPFGDEVEYSIKKLEENGADFVGSNCGKGFEDMLKIAPI 220 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHH----HGEHCAQLADYLPQWQAAGARLIGGCCR 297 + T LP+++ PN+G W + + E + ++ + IGGCC Sbjct: 221 IRRSTRLPVLIQPNAG------IPRWENGKLLYPESPEKFKTFVDEMIKLKINFIGGCCG 274 Query: 298 TTPADIAALK 307 TTP I K Sbjct: 275 TTPKHIEVFK 284 >UniRef50_C6D4G9 Methylenetetrahydrofolate reductase n=12 Tax=cellular organisms RepID=C6D4G9_PAESJ Length = 632 Score = 90.1 bits (222), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 98/302 (32%), Positives = 138/302 (45%), Gaps = 38/302 (12%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 KQ IL DGAM T L G + S ++ + P++I VH YY AGA+ T ++ Sbjct: 10 KQRILTGDGAMGTYLYQMGFPVGVSY--EELNMTRPDVIEGVHRRYYEAGARVIETNTFS 67 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKA--REAYLAENPQAGTLLVAGSVGPYGAYLA 130 A + GL E +A+ V +A+ A +AY V G+VG A Sbjct: 68 ANLVKLSKYGL-EPDMEAINRAGVRIAKAAAGEDAY-----------VVGAVGSIRAGKL 115 Query: 131 DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE---ALAELLTAYP 187 D S E AF R +++ALL G D + ET +F E+ LA LT P Sbjct: 116 K------DVRTS-EVSHAFER-QLDALLVEGVDGILFETFYDFDEMRLALGLARKLTQLP 167 Query: 188 RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALEN-TTAALQHLHGLT 246 F +D DGT L D LL V +G NC + N A++ + G Sbjct: 168 ---VICQFAAQDVGRTQDGTGLLDAFTLLKDEGADV-VGFNCRSGPNGIMRAVESIGGPV 223 Query: 247 VLPLVVYPNSG--EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 LPL ++PN+G ++ D K + ++ A+ A Q+ GAR+IGGCC TTP IA Sbjct: 224 ELPLSIFPNAGIPDYVDGKYK-YSAGPDYFAETA---LQFADRGARIIGGCCGTTPEHIA 279 Query: 305 AL 306 A+ Sbjct: 280 AM 281 >UniRef50_B0K7W0 Homocysteine S-methyltransferase n=13 Tax=Firmicutes RepID=B0K7W0_THEP3 Length = 807 Score = 90.1 bits (222), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 80/297 (26%), Positives = 139/297 (46%), Gaps = 31/297 (10%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 +++ DGAM T+L+ RG + + + +PE++ ++H Y AGA T ++ A Sbjct: 12 VIVFDGAMGTQLQERGLKTGE--CPEYMNITHPEVVFDIHRSYIEAGADVIETNTFGANR 69 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 A GL E + ++ ++V++A++A + + P VA S+GP G L + Sbjct: 70 IKLAKYGL-ENEVFNIVTQAVKIAKEASK----DKP------VALSIGPIGELLTPYGDM 118 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 D EA+ F + V A AGAD++ ET+ + +EA A +L A + Sbjct: 119 TFD-----EAYDVF-KEVVIAAERAGADIVLIETMSDM--LEAKAAILAAKENSNMKVIC 170 Query: 196 TL---RDSEHLSDGTPLRDVVALLA-GYPQVVALGINC-IALENTTAALQHLHGLTVLPL 250 T+ D L P+ VV+L G A+G+NC + + ++ + ++ +P+ Sbjct: 171 TMTFQEDGRTLMGSDPITVVVSLQGLGLD---AIGVNCSTGPDKMVSVVEKMSQVSRIPI 227 Query: 251 VVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 + PN+G KT + + A + P GA ++GGCC TTP I +K Sbjct: 228 IAQPNAGMPVIRDGKTVYDLKPE--EFASFFPLLVEKGASIVGGCCGTTPHYIKLVK 282 >UniRef50_A1WU24 Homocysteine S-methyltransferase n=7 Tax=Proteobacteria RepID=A1WU24_HALHL Length = 305 Score = 89.7 bits (221), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 97/312 (31%), Positives = 138/312 (44%), Gaps = 30/312 (9%) Query: 10 LLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITA 69 + ++D++LLDG M EL R LWSA+V+++ P+L+ H D+ +AGA+ Sbjct: 1 MTQERDVVLLDGGMGQELRRRSSQPVTPLWSAQVMLDEPDLVTAAHRDFIQAGARVITAN 60 Query: 70 SYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYL 129 +Y ATP A G E +L +++ AR+AR+A ++ + +AG + P A Sbjct: 61 TYSATPQRLARDGAPEL-FDSLHAAALDAARQARDASGQQD-----VRIAGCLPPLVA-- 112 Query: 130 ADGSEYRGDYHCSVEAFQAFHRPRVEALLDA-GADLLACETLPNFSEIEALAELLTAYPR 188 YR D + +R VEA A G DL CET+ + + A Sbjct: 113 ----SYRPDVAPNDADCLEGYRRMVEAQAQAQGVDLFICETM-SLAREARAATEAAVESN 167 Query: 189 ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALG-----INCIALENTTAALQHLH 243 W +FT+ D DGT LR +L+ VVA G +NC E T A+ L Sbjct: 168 LPVWVAFTVDD----GDGTRLRSGESLIQAAQAVVAAGAERVLVNCAIPEAVTTAMGELT 223 Query: 244 GLTVLPLVVYPNSGEHYDA------VSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCR 297 GL V P Y N+ A V A A++ W GA L+GGCC Sbjct: 224 GLGV-PFGGYANAFTSVAALQPGGTVDVLESRTDLDPAAYAEHALHWVEQGATLVGGCCE 282 Query: 298 TTPADIAALKAR 309 PA IA L R Sbjct: 283 VGPAHIAELAER 294 >UniRef50_B9NLU8 Homocysteine S-methyltransferase family protein n=4 Tax=Rhodobacteraceae RepID=B9NLU8_9RHOB Length = 309 Score = 89.7 bits (221), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 91/302 (30%), Positives = 132/302 (43%), Gaps = 29/302 (9%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 DI LLDG++ EL R + LWS +V+++ P+L+ +VH DY+R GA A T +Y Sbjct: 3 DITLLDGSIGQELVKRSGDQPTPLWSTQVMMDRPDLVGDVHADYFRRGATVATTNTYALH 62 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 + G+ E + +L+ ++ +A A + Q +AG++GP A Sbjct: 63 RSRLRRIGM-EDKLASLVDAALS---QAERACVGSEGQ-----IAGALGPVLA------S 107 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 YR D + A V+ + D DL ET+ + E E A TA W + Sbjct: 108 YRPDLKPDPDEAAARFSELVQLMADR-VDLFLIETVSSVLEGEG-ALRGTANCGKPVWLA 165 Query: 195 FTLRDSE--HLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVV 252 ++ D + L G L D+ L+A + V A+ INC E AAL + L P Sbjct: 166 VSVNDEDGTRLRSGERLADIQPLIARF-DVAAVLINCSKPEAIPAALDVI-ALMGRPFGA 223 Query: 253 YPNSGEHY-DA-------VSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 Y N H DA V H A A + QW A GA ++GGCC P I Sbjct: 224 YANGFSHIADAFLTEAPTVDVLEQRHDLGPAAYAAHAMQWVAQGATIVGGCCEVGPDHIE 283 Query: 305 AL 306 L Sbjct: 284 TL 285 >UniRef50_A9FZY9 Methylenetetrahydrofolate reductase n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9FZY9_SORC5 Length = 624 Score = 89.4 bits (220), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 96/306 (31%), Positives = 136/306 (44%), Gaps = 30/306 (9%) Query: 1 MSQNNPLRALLD--KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDY 58 MS+ P LD ++ IL+ DGAM + L RG + + ++ V P+L++++H +Y Sbjct: 4 MSRTRPEAPFLDALRRSILVFDGAMGSLLYERGVFVTQNFE--QLNVARPDLVKKIHAEY 61 Query: 59 YRAGAQCAITASYQATPAGFAARGL-DEAQSKALIGKSVELARKAREAYLAENPQAGTLL 117 AGA T ++ A GL +E ++ L G AR ARE G Sbjct: 62 VAAGANVIETNTFGANRFRLERYGLVNEVRNFNLAG-----ARLAREI------AGGDAY 110 Query: 118 VAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE 177 VAGS+GP G L G R D + F + AL + GADLL ET + EI+ Sbjct: 111 VAGSIGPTG--LVPGVATRDDLAAASATFAE----QAGALAEGGADLLILETFRHLDEIK 164 Query: 178 -ALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTT 236 A+ +A P S T S +DG+ V L + V LG+NC + Sbjct: 165 LAIDAARSAAPGLPVLASMTFDTSGVAADGSEPERVARTLRDW-GVELLGVNCGDGPQLS 223 Query: 237 AALQHLHGLTVLPLVVYPNSG--EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGG 294 A+ LPL V PN+G D + + E+ A + Q AGA +IGG Sbjct: 224 LAMAERMATAGLPLCVQPNAGLPRTVDG-RQLYMATPEYFDVFARRMIQ---AGAAMIGG 279 Query: 295 CCRTTP 300 CC TTP Sbjct: 280 CCGTTP 285 >UniRef50_A6G2A6 Homocysteine S-methyltransferase, putative n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6G2A6_9DELT Length = 322 Score = 89.0 bits (219), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 103/314 (32%), Positives = 142/314 (45%), Gaps = 40/314 (12%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 LLLDGA+ATEL RG L L++A+ L+E P+L+ E+H DY AGAQ T S+ A Sbjct: 8 LLLDGALATELRRRGFELEAPLFAARALLEAPDLLVEIHRDYALAGAQVLSTNSFGLHAA 67 Query: 77 GFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYR 136 A G+ E Q++ L +SVEL AR+ + + VA SV P ++G Sbjct: 68 TLARAGMAERQAE-LAARSVELTFLARQLVRQSGSERTSFRVAASVPPPPPSPSEGD--- 123 Query: 137 GDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSFT 196 + E +A R AL+DAGADL+ ET I A E+ A W S Sbjct: 124 -----APELTRAALRSLASALVDAGADLVLFETFAKPEHIRAALEVAGAL-EVPVWLS-V 176 Query: 197 LRDSE-----HLSDGTPLRDVVALL--AGYPQVVALGINCIALENTTAALQHL------H 243 + D+ L G P + ALL G + AL +NC ++ AL L Sbjct: 177 VGDARPGHRGQLLGGVPFDALAALLREPGLRRPDALLLNCTQIDAVPRALDALLQTARAA 236 Query: 244 GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQL------ADYLPQWQAA--GARLIGGC 295 GL + L +YP+ G H GE ++ A + W AA + G C Sbjct: 237 GLEGVDLGLYPHLGRA--------RHDGEWIDRILEAEVYAGQIEAWMAARPALSIAGAC 288 Query: 296 CRTTPADIAALKAR 309 C +TPA + AL R Sbjct: 289 CGSTPAYVEALARR 302 >UniRef50_Q4FMM0 Homocysteine S-methyltransferase n=2 Tax=Candidatus Pelagibacter ubique RepID=Q4FMM0_PELUB Length = 302 Score = 89.0 bits (219), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 85/311 (27%), Positives = 142/311 (45%), Gaps = 45/311 (14%) Query: 18 LLDGAMATELEARGCNLADSLWSAKVLV--ENPELIREVHLDYYRAGAQCAITASYQATP 75 +LDG M EL ARG +LWSA ++ E +L+ + HLD+ +AGA+ +TA++ Sbjct: 11 ILDGGMGQELLARGMKPNGTLWSANAVLKEEYHQLLLDTHLDFIKAGAEVIVTATFTTRR 70 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 + E + + L K+ E+A+KA+E Q +L+AG + P YL Y Sbjct: 71 IRLRDNKI-EDKFEYLNKKAGEIAQKAKE-------QHPNVLIAGGLPP--QYLT----Y 116 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE----IEALAELLTAYPRARA 191 D E Q F+ LLD D + L + E IEA+ E Y Sbjct: 117 EEDTRPDDEIKQNFYDQA--KLLDPYIDFFYLDVLSSVKEFKLAIEAIEEFNKPY----- 169 Query: 192 WFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTV---- 247 + + +L G + D++ + + ++ L ++C++ EN L+ + L V Sbjct: 170 LIGAHISEGINLPSGEKISDIINNIK-HNNLLGLILSCVSPENFYENLEEVKNLGVPFGF 228 Query: 248 -LPLVVYPNSGEHYDA---VSKTWHHHGEHCAQ--------LADYLPQWQAAGARLIGGC 295 L V N + Y VSKT + + E Q +A+++ +++ AGA ++GGC Sbjct: 229 KLNAFVTTNPKDGYTNSYNVSKTGNPN-EFLGQRKDLTPELMANFVKKFKNAGATILGGC 287 Query: 296 CRTTPADIAAL 306 C T P+ I + Sbjct: 288 CETRPSHIKEM 298 >UniRef50_Q5KA93 Homocysteine S-methyltransferase, putative n=1 Tax=Filobasidiella neoformans RepID=Q5KA93_CRYNE Length = 381 Score = 88.6 bits (218), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 75/317 (23%), Positives = 130/317 (41%), Gaps = 64/317 (20%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 +IL+LDG M T LE+ G +++ LW ++ L NP++IR+VH Y + GA TA+YQ T Sbjct: 4 NILVLDGGMGTTLESLGVDISSPLWGSEALRTNPDVIRKVHEGYVQGGADLVETATYQLT 63 Query: 75 PAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG-------SVGPYG 126 P +++ ++ V+L + + N + T G S GPYG Sbjct: 64 PQNLCDHLHCPREEAECILCSGVKLVASCIASCSSRNEEHNTKSKGGNKSKVVLSFGPYG 123 Query: 127 AYLADGSEYRGDY---------------------HCSVEAFQAFHRPRVEALLDAGA--- 162 + L G EY G Y +++A H ++EA+ GA Sbjct: 124 STLQPGQEYGGIYPPPFGPSTSTNAFPPDSNDEEEAAIQALAYHHLDKLEAISHDGAAWR 183 Query: 163 --DLLACETLPNFSEIEAL-----------------AELLTAYPRARAWFSFTLRDSEH- 202 + +A ET+P E+ + + + + + W + +H Sbjct: 184 EVEWIAFETIPVLHEVRGIRRAMAILRGKLSALYADGDNIDLWWEKKFWITSPFPMGQHP 243 Query: 203 --LSDGT--PLRDVVALLAGYPQVV--ALGINCIA------LENTTAALQHLHGLTVLPL 250 L DG+ + V+ L P + +GINC L ++ + + + Sbjct: 244 QLLPDGSHASIPQVIHSLFSGPDPIPNGIGINCTNPSYLHFLSSSFTSHLPFEFFGKVEM 303 Query: 251 VVYPNSGEHYDAVSKTW 267 V+YP+ G+ YD ++ W Sbjct: 304 VIYPDGGQMYDTTTRAW 320 >UniRef50_A1AKP7 Methylenetetrahydrofolate reductase n=10 Tax=Desulfuromonadales RepID=A1AKP7_PELPD Length = 615 Score = 87.8 bits (216), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 98/302 (32%), Positives = 139/302 (46%), Gaps = 33/302 (10%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K ++L DGA+ T L ARG L S ++ + P L+RE+ DY AGAQ T ++ Sbjct: 8 KGEVLTGDGALGTMLYARGVGLDSSFE--QLNLTRPALVRELADDYVAAGAQVIETNTFG 65 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A AA GL++ + ++ AR AR+A Q +LVAGSVGP Sbjct: 66 ANYTRLAALGLEQRVWEI----NLAGARIARQAA----DQGRDVLVAGSVGPL------- 110 Query: 133 SEYRGDY-HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARA 191 RGD E R + +AL + G DLL ET + +++ A + A Sbjct: 111 PRIRGDEAESDQERMAELFRVQCQALAEGGVDLLLLETFSSLTQLAAAVQAARCTGLTVA 170 Query: 192 WFSFTLRDSEHLSDGTPLRDVVALL--AGYPQVVALGINCIA--LENTTAALQHLHGLTV 247 S + +DG + + A + AG V G NC A LE ++ L +T Sbjct: 171 A-SMAFLEGGRSADGATVEEFCAAMERAGADLV---GANCGAGPLE-LVKVVRRLAAVTH 225 Query: 248 LPLVVYPNSG--EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAA 305 P+ Y NSG E++D + E+ A +A L AAGA L+GGCC TTP IAA Sbjct: 226 KPITAYANSGFPEYHDG-RFIYRATPEYLATMAGEL---VAAGASLVGGCCGTTPEHIAA 281 Query: 306 LK 307 + Sbjct: 282 IS 283 >UniRef50_A9B657 Methylenetetrahydrofolate reductase n=1 Tax=Herpetosiphon aurantiacus ATCC 23779 RepID=A9B657_HERA2 Length = 617 Score = 87.0 bits (214), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 93/310 (30%), Positives = 146/310 (47%), Gaps = 49/310 (15%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 Q LL DGAM T+L RG + D + A L + P+++RE+H Y AGA T +Y A Sbjct: 11 QRALLCDGAMGTQLYGRGIDF-DECFDALNLTQ-PDVVREIHQSYIEAGADIIETNTYGA 68 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGT-LLVAGSVGPYGAYLADG 132 GL + + + + + ++LAR+ARE AGT L+AG+VGP G L Sbjct: 69 NRFKLEPFGLAD-KVRQINHRGMKLAREAREI-------AGTNTLIAGAVGPLGVLLQ-- 118 Query: 133 SEYRGDYHCSVE--AFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRAR 190 Y E A +AF ++ LL+ GADLL ET FS+ L E+L A A+ Sbjct: 119 -----PYGPLTEQAAHEAFAE-QIGTLLEQGADLLMFET---FSD---LREMLIAVKAAK 166 Query: 191 --------AWFSFTLRDSEHLSDGTP---LRDVVALLAGYPQVVALGINC-IALENTTAA 238 A +F D + TP +R +V L V +G+NC + + Sbjct: 167 QVGDLPIVAQMTFA-EDGRTVLGNTPEEVVRKLVEL-----GVAVVGVNCSVGSQRVFRV 220 Query: 239 LQHLHGLT-VLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW-QAAGARLIGGCC 296 +Q + + +P+ PN+G + ++ ++ +ADY + + +++GGCC Sbjct: 221 VQSMRAVNPTIPISAQPNAGWPTERHNRVFYPSSPEY--MADYARRMVEELNVQIVGGCC 278 Query: 297 RTTPADIAAL 306 TTP I+ + Sbjct: 279 GTTPQHISNM 288 >UniRef50_Q2JJL4 Methionine synthase n=30 Tax=Bacteria RepID=Q2JJL4_SYNJB Length = 1224 Score = 87.0 bits (214), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 81/314 (25%), Positives = 129/314 (41%), Gaps = 41/314 (13%) Query: 13 KQDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREVHLDYYRAGAQCA 66 ++ +++ DGAM + L+A+ AD + +++ PE + VH + GA Sbjct: 10 QERVIVFDGAMGSSLQAQNLTAADFGGPELEGCNEMLVLTKPEAVERVHRGFLEVGADVV 69 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 T ++ AT A G+ E + + + R A E E P+ VAGS+GP Sbjct: 70 ETNTFGATSIVLAEYGIPEKAYELNVAAARLAKRVAAEFATPEKPR----FVAGSIGPTT 125 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA-----LAE 181 G H S + +A + +V+ L+D GADLL ET + + +A E Sbjct: 126 KLPTLG-------HISFDEMRAAYEEQVQGLVDGGADLLIIETCQDILQTKAALVAVQQE 178 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQ 240 R S T + GT + +A+L YP + LG+NC + ++ Sbjct: 179 FARRGIRLPVVVSLTFEVQGTMLVGTEIGAALAILEPYP-IDVLGLNCATGPDKMVEHIR 237 Query: 241 HLHGLTVLPLVVYPNSG--------EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLI 292 +L + P+ PN+G HY + H EH + G ++ Sbjct: 238 YLSRHSPFPISCIPNAGLPENIGGKAHYKLTPEQLRFHLEHFV---------RDLGVAVV 288 Query: 293 GGCCRTTPADIAAL 306 GGCC T P IAAL Sbjct: 289 GGCCGTRPEHIAAL 302 >UniRef50_D1N227 Methylenetetrahydrofolate reductase n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N227_9BACT Length = 605 Score = 85.9 bits (211), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 82/297 (27%), Positives = 132/297 (44%), Gaps = 29/297 (9%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 + + + DGA+ TE+ R + S + P++I ++H Y +AGA+ T +Y A Sbjct: 10 ESLTIFDGAIGTEIYRRNFFVNASFEQLNLTA--PDVILDIHHQYLKAGAEVLTTNTYNA 67 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 A GL E Q++A+ V+LAR+A VA SVGP G +D Sbjct: 68 NSRRLAKFGLSE-QTEAINRAGVKLAREAAAGKAL---------VAASVGPVGEPDSD-- 115 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWF 193 D E ++ AL D AD + E+L ++++A+ E + +P Sbjct: 116 ---QDRRTRAELLAE----QIRALSD--ADFIIFESLRRAADLKAVLEAVAEFPELVYVP 166 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAGY---PQVVALGINC-IALENTTAALQHLHGLTVLP 249 SF + H++D + + + L P A+G+NC E+T L+ L LT LP Sbjct: 167 SFAIEPHPHINDSATIAEFMEQLNASRPCPAPTAIGLNCGGGPESTLGVLEELTALTQLP 226 Query: 250 LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 ++V PN+G+ + + + Y ++ GA IGGCC TP I L Sbjct: 227 VIVQPNAGQPKGVDGRMIYMTSAE--YFSTYAKRYAMLGAAAIGGCCGITPDHIEEL 281 >UniRef50_B7I892 Homocysteine S-methyltransferase family protein n=12 Tax=Proteobacteria RepID=B7I892_ACIB5 Length = 313 Score = 85.9 bits (211), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 85/303 (28%), Positives = 122/303 (40%), Gaps = 33/303 (10%) Query: 18 LLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPAG 77 +LDG + EL RG WSA L+E PE ++EVHLD+ AGA+ T +Y P Sbjct: 24 ILDGGLGRELARRGAPFRQPEWSALALIEAPETVKEVHLDFINAGAEVITTNNYAVVPFH 83 Query: 78 FAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP-YGAYLADGSEYR 136 E LI ++E A+ A + + +AG + P +G+Y AD Sbjct: 84 IGQERF-ETDGVRLIKVAIEQAKNAVKE------SGKNVKIAGCLPPLFGSYRAD----- 131 Query: 137 GDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSFT 196 E + P + L D ET E+E + LL + W SFT Sbjct: 132 ---LFQPEQAKNLAEPIINTLAPE-VDFWLAETQSCLKEVETVHALLPQDGK-DYWVSFT 186 Query: 197 LRDSEH-----LSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLT--VLP 249 L+D L G ++ V + A+ NC E A+ + GL + Sbjct: 187 LQDEIKQEQALLRSGENMQQVADFIK-QSNAKAVLFNCCQPEVILQAINEIKGLIPESVQ 245 Query: 250 LVVYPNSGEHYDAVSKTWHHHGEHCAQLAD------YLPQWQAAGARLIGGCCRTTPADI 303 + Y N+ D S T + + + D + QWQ AGA L+GGCC P I Sbjct: 246 IGAYANAFPPQDE-SATANDGLDEIRKDLDAPAYLGFAKQWQQAGASLVGGCCGIGPEHI 304 Query: 304 AAL 306 A L Sbjct: 305 AEL 307 >UniRef50_B7VQ49 Homocysteine S-methyltransferase family protein n=17 Tax=Vibrionales RepID=B7VQ49_VIBSL Length = 301 Score = 85.5 bits (210), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 88/316 (27%), Positives = 141/316 (44%), Gaps = 44/316 (13%) Query: 11 LDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITAS 70 ++ + + +LDG M EL+ G + LWSA+ L+E P+ + + H ++ AGA+ IT S Sbjct: 1 MNMKTLTILDGGMGRELKEIGAPFSQPLWSAQALIEAPDFVSQAHQNFVDAGAEILITNS 60 Query: 71 YQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV-GPYGAYL 129 Y P L E + L S ELA+ +A+N + T+ VAG++ P+G+ Sbjct: 61 YACVPFHLGEE-LFEQRGFELAALSGELAKA-----VADNA-SHTIKVAGAIPPPFGS-- 111 Query: 130 ADGSEYRGDYHCSVEAFQAFHRPRVEALLDA---GADLLACETLPNFSEIEALAELLTAY 186 YR D EA P ++ L DA DL ET+ + E E++ +L Sbjct: 112 -----YRPDLFKVEEA-----APIIQTLYDAQDPNIDLWIAETICSLQEFESIHAVLKQS 161 Query: 187 PRARAWFSFTLRDSE----HLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHL 242 + +++F+L D++ ++ G + D + LA + NC E A+ Sbjct: 162 NKP-CYYAFSLEDTKGDSANIRSGESVTDSIK-LACQSNAKGIMFNCSVPEVMDQAIIDA 219 Query: 243 HGL-----TVLPLVVYPN-----SGEH--YDAVSKTWHHHGEHCAQLADYLPQWQAAGAR 290 + + L + VY N S EH D + + G+ Y +W A GA Sbjct: 220 KKVIGELGSDLEIGVYANNFAPISSEHEANDMLQEIRELDGQG---YLVYAKRWHALGAN 276 Query: 291 LIGGCCRTTPADIAAL 306 +IGGCC P I AL Sbjct: 277 IIGGCCGIGPKHIQAL 292 >UniRef50_A0Q0N0 5-methyltetrahydrofolate--homocysteine methyltransferase, putative n=42 Tax=Bacteria RepID=A0Q0N0_CLONN Length = 808 Score = 85.5 bits (210), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 86/301 (28%), Positives = 129/301 (42%), Gaps = 27/301 (8%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K +IL+ DGAM T L+ G NL +S EN LI ++H Y AGA T ++ Sbjct: 15 KDNILIFDGAMGTMLQKSGLNLGESPEKLNFSHEN--LIIDIHKKYIEAGANVITTNTFG 72 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A + +I K+V LA KA+E +A +GP G L Sbjct: 73 ANELKLKNTSF---SVEDVIYKAVSLAIKAKEDT--------NCFIALDIGPIGQLLEPM 121 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA--LAELLTAYPRAR 190 + + +A F R +++A + AG DL+ ET+ + E++A LA T Sbjct: 122 GTLKFE-----DAINIFKR-QIKAGVKAGVDLILIETMTDLYEMKAAILAAKETCDLPIF 175 Query: 191 AWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLP 249 A SF D + P V L A V A+G+NC + + ++ T LP Sbjct: 176 ATMSFE-NDGRTFTGCLPESMAVTLEA--LGVTAVGVNCSLGPKELKPIVKKTLEHTNLP 232 Query: 250 LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKAR 309 ++V PN+G + + + +Y+ G +IGGCC TTP I LK+ Sbjct: 233 VIVQPNAG--LPTIVNGQSLYTITPEEFCNYVESLIDMGVSIIGGCCGTTPDFIKCLKSM 290 Query: 310 S 310 S Sbjct: 291 S 291 >UniRef50_B3E428 Methionine synthase n=91 Tax=Bacteria RepID=B3E428_GEOLS Length = 1169 Score = 85.1 bits (209), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 99/324 (30%), Positives = 149/324 (45%), Gaps = 37/324 (11%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSA------KVLVENPELIREV 54 M+ N L+AL Q IL+LDGAM T+L+AR AD A +++ P++I +V Sbjct: 1 MTNNPVLQAL--SQCILILDGAMGTQLQARNLTAADFGGEAYEGCNEMLVLTRPDVIEDV 58 Query: 55 HLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVEL-ARKAREAY-LAENPQ 112 H Y AGA T S+ +T A GL A + K+ L ARKA +AY + P+ Sbjct: 59 HKAYLEAGADIVETCSFGSTDIVLAEYGL--ADKVFELNKAAALVARKACDAYSTPDKPR 116 Query: 113 AGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPN 172 VAGS+GP ++ + E R + LL G DLL ET + Sbjct: 117 ----FVAGSMGPTTRTISVTG------GVTFEQLVTAFRDQTIGLLAGGVDLLLLETAQD 166 Query: 173 FSEIEALAE-LLTAYP----RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQ---VVA 224 ++A AE + A+ R S T+ + + G + + A L + +++ Sbjct: 167 TLNLKAGAEGIRLAFEQTGQRVPLMVSGTIEPTGTMLAGQNVEALYASLTHLEENLGLIS 226 Query: 225 LGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQ 283 +G+NC E T L+ L L + VYPN+G + ++ E LA L + Sbjct: 227 IGLNCATGPEFMTDHLRALSELATCHISVYPNAG-----LPDENGNYAESPDSLAQKLSR 281 Query: 284 WQAAG-ARLIGGCCRTTPADIAAL 306 + G +IGGCC T+PA IAA+ Sbjct: 282 FVDEGWLNIIGGCCGTSPAHIAAI 305 >UniRef50_B7Q2S9 5-methyltetrahydrofolate:homocysteine methyltransferase, putative n=1 Tax=Ixodes scapularis RepID=B7Q2S9_IXOSC Length = 185 Score = 85.1 bits (209), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 64/181 (35%), Positives = 88/181 (48%), Gaps = 11/181 (6%) Query: 115 TLLVAGSVGPYGAYLADGSEYRGDY--HCSVEAFQAFHRPRVEALLDAGADLLACETLPN 172 T AGSVG YGAY DGSEY G Y SV+ +HR RV+ L+ G DLLA ET+P Sbjct: 4 TSAFAGSVGSYGAYPYDGSEYTGSYADTMSVKELCDWHRFRVQHLVRLGCDLLAFETIPA 63 Query: 173 FSEIEALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGY---PQVVALGINC 229 E AL +LL +P + W SF +D + + G L+ + + G Q+ A+ +NC Sbjct: 64 LQEALALLQLLREHPGTKGWLSFGCQDEKLTAKGECLQKAIQAVLGKDSGSQICAIRVNC 123 Query: 230 IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGA 289 + L+ PLV Y DA +W + QL +Y+ +W AG Sbjct: 124 CRPDMVGLLLKDARKEGQPPLVAYA------DAEVASWTLVPKDSDQLGNYVAEWYRAGV 177 Query: 290 R 290 R Sbjct: 178 R 178 >UniRef50_Q4PDM6 Putative uncharacterized protein n=1 Tax=Ustilago maydis RepID=Q4PDM6_USTMA Length = 448 Score = 85.1 bits (209), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 71/206 (34%), Positives = 102/206 (49%), Gaps = 38/206 (18%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADS---LWSAKVLVENPEL---------IREV 54 L +LL I +LDG +AT LE G + S LWSA++L E + I + Sbjct: 10 LESLLSPARIGILDGGLATYLE-DGLDFDLSKGPLWSARLLDEKEDDVSDGKGQKGIFDA 68 Query: 55 HLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAG 114 HL Y +AGA TA+YQA+ FA D+ + L+ K+V+LA A A+ N + G Sbjct: 69 HLHYLQAGAGIIGTATYQASLESFARANYDQVSASHLMSKAVDLACDALHAHNISNNKVG 128 Query: 115 TL-------LVAGSVGPYGAYLADGSEYRGDY--------------HCSVEAFQAFHRPR 153 L++ S+GPYGA L++G+EY GDY S+E AFH+ R Sbjct: 129 VASAASARPLLSLSLGPYGAMLSNGAEYTGDYRRTFLAESDPLREQQPSLEEMMAFHQRR 188 Query: 154 VEALLDAGA----DLLACETLPNFSE 175 +EA + + +LA ET+P E Sbjct: 189 IEAFIAQPSWEHVGVLAVETVPRADE 214 >UniRef50_A2R696 Contig An15c0240, complete genome n=9 Tax=Leotiomyceta RepID=A2R696_ASPNC Length = 353 Score = 84.7 bits (208), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 94/354 (26%), Positives = 145/354 (40%), Gaps = 68/354 (19%) Query: 13 KQDILLLDGAMATELEAR-GCNLADS---LWSAKVLVENPELIREVHLDYYRAGA-QCAI 67 K IL+LDG + T L+ + S LWS+ +++ +P + D+ A + Sbjct: 3 KTPILILDGGLGTSLQDHYNITFSSSTTPLWSSHLMISDPSTLLSCQRDFTTTAAVDVLL 62 Query: 68 TASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYL-------AENPQAGTLLVAG 120 TA+YQ +P GF Q + R++ YL + Q + VA Sbjct: 63 TATYQVSPEGF--------QRTKTPSHPTGIPRESIAGYLRTALDVAGQAVQNTSASVAL 114 Query: 121 SVGPYGAYLADGSEYRGDY---HCSVEAFQAFHRPRVEALLDAGAD---------LLACE 168 S+GPYGA + G EY G Y H + E +H R+ D + +A E Sbjct: 115 SLGPYGACMIPGQEYSGKYDGEHDTEEKLWRWHTDRLGLFNDEAMEGMRLGERVKYIAME 174 Query: 169 TLPNFSEIEALAELLTAYPRARA---WFS--FTLRDSEHLSDGTPLRDVV--ALLA--GY 219 T+P E+ A+ + + W + F + D + L DG+ + +VV ALL G Sbjct: 175 TVPRIDEVRAVRRAVGSSRFCEGIPFWVACVFPIEDKDTLPDGSTVDEVVEAALLPIEGG 234 Query: 220 PQVVALGINCIALENTTAALQHLHGLTV------------LPLVVYPN--SGEHYDAVSK 265 +GINC L + L L G V LV+YP+ GE Y+ ++ Sbjct: 235 ATPWGIGINCTKL-HKLPRLVKLFGDAVERLLRDGRIQERPALVLYPDGTQGEVYNTATQ 293 Query: 266 TWHHHGEHCA---------QLADYLPQWQAAG---ARLIGGCCRTTPADIAALK 307 TW + QLA + A G + L+GGCC+ + DI L+ Sbjct: 294 TWEKVQDKSGAADSRPWEVQLAQVVNDASATGQFSSILVGGCCKASFNDIKRLR 347 >UniRef50_Q2LQ11 Methylenetetrahydrofolate reductase n=1 Tax=Syntrophus aciditrophicus SB RepID=Q2LQ11_SYNAS Length = 618 Score = 84.3 bits (207), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 90/289 (31%), Positives = 122/289 (42%), Gaps = 22/289 (7%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 L+ DGAM T + +G + + L E P LI +H Y +AGAQ T S+ A Sbjct: 16 LIFDGAMGTMIYEKGV-FIQTCYDELCLTE-PGLILGIHEQYAQAGAQVLETNSFGANRI 73 Query: 77 GFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYR 136 A GL E + A LA TL VAGSVGP G Sbjct: 74 KLRAYGLAEKVADI----------NRAAARLARQAAGTTLYVAGSVGPC---TQGGQVIT 120 Query: 137 GDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSFT 196 G VEA AF R ++EAL + G DLL ET + E++ LA + SF Sbjct: 121 GRDMAEVEA--AF-REQMEALTEEGVDLLLLETFSDLKELQ-LAARVARERGVPVLASFA 176 Query: 197 LRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLVVYPN 255 + D + GTP + A L P V +G+NC AL + + P++V PN Sbjct: 177 VDDDGETAAGTPAEKMAAALEKDPHVDVIGLNCGTGPAGIYEALLKVLPVAGKPVIVMPN 236 Query: 256 SGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 +G + +T + +Y ++ G R IGGCC PA IA Sbjct: 237 AGMPREIGGRTLYLANPE--YFTEYAKKFIELGVRGIGGCCGVHPAHIA 283 >UniRef50_A6S563 Putative uncharacterized protein n=2 Tax=Sclerotiniaceae RepID=A6S563_BOTFB Length = 369 Score = 84.3 bits (207), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 86/364 (23%), Positives = 146/364 (40%), Gaps = 78/364 (21%) Query: 16 ILLLDGAMATEL-EARGCNLADS--LWSAKVLV----ENPELIREVHLDYYRAGAQCAIT 68 I LLDG + T L ++ + LWS+++L+ P+ + + AGA +T Sbjct: 7 IHLLDGGLGTTLGDSHQVQFTEKEPLWSSQLLIPTHPHGPKTLLATQKSFVDAGADILLT 66 Query: 69 ASYQATPAGFAARGL---------------DEAQSKALIGKSVELARKAREAYLAENPQA 113 A+YQ + GF G D+ + ++ +V++A A N + Sbjct: 67 ATYQTSYEGFGGSGYAVHSHSSSNSGKADGDKEEVNGIMRSAVDIASDAFSTKKDSNGK- 125 Query: 114 GTLLVAGSVGPYGAYLADGSEYRGDY---HCSVEAFQAFHRPRVEALLD-----AGADLL 165 +A S+G YGA + G EY G Y H S E ++H R+ D + Sbjct: 126 ----IALSLGAYGAIMTPGQEYTGKYDDDHKSSEQLSSWHHERISVFSRDPKCWERVDYV 181 Query: 166 ACETLPNFSEIEALAELLTAYPRARA--------WFSFTL-RDSEHLSDGTPLRDVVALL 216 A ET+P EIE + + + + W + + L G+ ++ ++ + Sbjct: 182 AFETIPLLEEIEGVRKSMGEVENSNGGTAGSKPFWITCVFPGEGNCLPGGSSVQQIMQAM 241 Query: 217 ----AGYPQVVALGINC----------IALENTTAALQHLHGLTVLP-LVVYPN---SGE 258 G P +G+NC + E AL ++ P LVVYP+ GE Sbjct: 242 LGNKGGSPVPFGIGLNCTKVGKVESLILEFEQEVKALIEKGDVSEWPSLVVYPDGTIKGE 301 Query: 259 HYDAVSKTWHHH---GEHCAQLADYLPQ----------WQAAGARLIGGCCRTTPADIAA 305 Y+ +K W G+ Q + + + W+ ++GGCC+TTP +I Sbjct: 302 VYNTSTKVWEIREPPGKEDLQWDEAVLEIVRRARDRGLWEDI---IVGGCCKTTPREIGK 358 Query: 306 LKAR 309 L+ R Sbjct: 359 LRER 362 >UniRef50_Q67LG1 5-methyltetrahydrofolate S-homocysteine methyltransferase n=2 Tax=Clostridiales RepID=Q67LG1_SYMTH Length = 859 Score = 84.0 bits (206), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 88/300 (29%), Positives = 131/300 (43%), Gaps = 28/300 (9%) Query: 14 QDILLLDGAMATELEARGC--NLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 +++L+ DGAM T L+A+G +W+ +E PE + VH Y AGAQ T ++ Sbjct: 9 REVLVFDGAMGTMLQAQGLAPGACPDVWN----LERPEDVIAVHRAYVEAGAQILETNTF 64 Query: 72 QATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLAD 131 +TP GL + + + ++ V AR+A AG VAGS+GP GA + Sbjct: 65 GSTPIRLGHYGLQD-RCRDIVVAGVRCAREA---------AAGRAWVAGSMGPLGALVEP 114 Query: 132 GSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY-PRAR 190 E D + A QA A +A D + ET+ + +E+ A + P R Sbjct: 115 LGELPFDEAYAQFAVQA------RAFAEAQPDFIIIETIADLNELRAAVLACRDHAPGIR 168 Query: 191 AWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLP 249 TL S GT +L V +G NC + + A+ + + +P Sbjct: 169 IIAQITLDPSGRAFTGTDPETAALVLQSLGADV-IGFNCSVGPDLLVEAVARMARVARVP 227 Query: 250 LVVYPNSG-EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 + V PN+G T G + A Y P+ AGA L+GGCC TTP I L+A Sbjct: 228 ISVQPNAGLPLLQPDGATRFPMGPE--EFAAYGPKLVEAGAALVGGCCGTTPEHIRRLRA 285 >UniRef50_Q1AXR8 Methylenetetrahydrofolate reductase n=2 Tax=Bacteria RepID=Q1AXR8_RUBXD Length = 611 Score = 84.0 bits (206), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 90/302 (29%), Positives = 131/302 (43%), Gaps = 24/302 (7%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 R LLD + +L+ DGAM T L RG A+ + +PEL+ +H +Y RAGA+ Sbjct: 5 FRDLLDGR-VLVGDGAMGTLLADRGVGYGHPY--ARANLTHPELVERLHGEYVRAGARAI 61 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVEL-ARKAREAYLAENPQAGTLLVAGSVGPY 125 T ++ A A L+E + E+ AR A A A +LV G++GP Sbjct: 62 ETNTFSANRIKLAGHRLEE--------RVREINEAGARLARRAAAEAAERVLVLGAIGPL 113 Query: 126 GAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA 185 G LA E +A R + EALL+ G+D L ET + E+ E + Sbjct: 114 GRPLAPVG------RVPREEARALFREQAEALLEGGSDALLLETFTDLEELRLAWEAVRD 167 Query: 186 YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL 245 + + D E L++G P R ++G+ V +G NC + Sbjct: 168 LGAPVLAYKTFVEDGETLAEGLPER-AAREISGW-GVELVGSNCTVGPQRMLGIVEQMSA 225 Query: 246 TVLPLVVYPNSG-EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 P+ +PN G + + H EH A+ Y + AGAR +GGCC TTP I Sbjct: 226 AAGPVAAFPNPGLPQLVEGTVRYSHDVEHFAR---YGLRLAEAGARFVGGCCGTTPEHIR 282 Query: 305 AL 306 AL Sbjct: 283 AL 284 >UniRef50_A5ZUF2 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=A5ZUF2_9FIRM Length = 289 Score = 83.2 bits (204), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 78/304 (25%), Positives = 140/304 (46%), Gaps = 41/304 (13%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 ++IL+LDGA + L A G + + + ++++ ++I+++ Y +AG+Q ++ Sbjct: 11 ENILILDGATGSNLMASG--MPRGICTETWVIDHKDIIQDLQRAYIQAGSQVIYAPTFGG 68 Query: 74 TPAGFAARGLD---EAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYL- 129 GL E ++ L+G S ELA + VAG + G+++ Sbjct: 69 NSINLEKHGLRDKIEEINRTLVGYSKELAGSG-------------IYVAGDITTSGSFIT 115 Query: 130 ADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRA 189 ADG DY + EA+ + ++ L DAG DL+A ET+ N E A + + Sbjct: 116 ADG-----DYTYT-EAYNMYQE-QIRILADAGIDLIAAETMINIEETLAAVDAAASVCDL 168 Query: 190 RAWFSFTLR-DSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTV 247 + T+ D S G + V+L A A+GINC + + + ++++ Sbjct: 169 PIMCTMTVEADGSIFSGGNAVEAAVSLEAAGAD--AVGINCSVGPDQLVSVVRNIKENVS 226 Query: 248 LPLVVYPNSG-----EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPAD 302 +P++ PN+G E +AV + + + A ++ GA ++GGCC TTP+ Sbjct: 227 IPVIAKPNAGMPVIDEKGNAV------YSMNAEEFAHHMKVLIENGASVVGGCCGTTPSF 280 Query: 303 IAAL 306 I AL Sbjct: 281 IKAL 284 >UniRef50_D1Y627 Homocysteine S-methyltransferase n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y627_9BACT Length = 798 Score = 83.2 bits (204), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 81/296 (27%), Positives = 136/296 (45%), Gaps = 33/296 (11%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 +++ DGAM T L+ +G L + S V P+LI +H +Y+ AG T ++ A P Sbjct: 8 VVMFDGAMGTMLQKKGLKLREIPESLNV--SRPDLIESIHREYFAAGCDFVQTNTFGANP 65 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 + Q +IG +V++AR+A +A+ + G LL VGP G +A + Sbjct: 66 YKLEGTAYETEQ---VIGAAVKIARRAADAFSGK----GILL---DVGPSGRAMAPVGDA 115 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEI-EALAELLTAYPRAR--AW 192 D E + + R + AGA+L L F+++ EA A L A + + Sbjct: 116 DFD-----EIYGSVARQ-----VRAGAELCDGILLETFTDLLEAKASALAALENSDKPVF 165 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLV 251 + + ++ GTP+ ++ G + LG+NC + ++ L + +P++ Sbjct: 166 LTMSFQEDGRTFFGTPVEAMIMTFEGL-GLSGLGVNCSLGPAQLAPIVKKLTAHSRVPVI 224 Query: 252 VYPNSGEHY--DAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAA 305 V PN+G D VS GE A++L Q+ G +GGCC TTP ++A Sbjct: 225 VQPNAGLPVVRDGVSGWDVSPGE----FANWLGQFVDWGTAFVGGCCGTTPEFLSA 276 >UniRef50_C3XLV5 S-methyltransferase n=2 Tax=Helicobacter RepID=C3XLV5_9HELI Length = 1154 Score = 82.8 bits (203), Expect = 1e-14, Method: Composition-based stats. Identities = 82/321 (25%), Positives = 141/321 (43%), Gaps = 46/321 (14%) Query: 13 KQDILLLDGAMATELEAR---------------GCNLADSLWSAKVLVENPELIREVHLD 57 K+ +L+LDGAM TE++ GC+ A +L++ ++I+ +H Sbjct: 8 KERVLILDGAMGTEIQKHNIQTWGVNAKGEKLDGCSEALNLYAK-------DIIKAIHTS 60 Query: 58 YYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLL 117 Y +AGA T ++ P A GL+E K + VELA++ + + Q L Sbjct: 61 YLQAGANILKTNTFGVMPWVLAEYGLEE-HCKEIAKTGVELAKECIKKHSPLKNQNNALF 119 Query: 118 VAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE 177 VA S+GP G++ H + ++ + + VE +A AD++ ET + +I+ Sbjct: 120 VAASLGP-------GTKLPSLGHITYDSMEEGYALCVEGFKEADADVILLETAQDPLQIK 172 Query: 178 -ALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTT 236 AL + P S T+ + + GT + + +L Y +++LGINC Sbjct: 173 AALNAIKNTAPEIPIMVSVTIETTGTMLIGTDITTLFHILEPY-DLLSLGINC----GLG 227 Query: 237 AALQHLHGLTV-----LPLVVYPNSG--EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGA 289 L H H +T+ P+ ++ N+G E+ V+ E +L + G Sbjct: 228 PDLAHKHLVTLSEVCKFPISIHTNAGLPENRGGVTYYPMDAEEFSTIEKSFL---EIPGV 284 Query: 290 RLIGGCCRTTPADIAALKARS 310 +GGCC TTP I L ++ Sbjct: 285 AFLGGCCGTTPEHIRQLVQKT 305 >UniRef50_C0QY88 5-methyltetrahydrofolate--homocysteine methyltransferase n=2 Tax=Brachyspira RepID=C0QY88_BRAHW Length = 873 Score = 82.0 bits (201), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 91/336 (27%), Positives = 150/336 (44%), Gaps = 65/336 (19%) Query: 7 LRALLDKQDILLLDGAMATELEAR---------------GCNLADSLWSAKVLVENPELI 51 L+ L+ KQ L++DGA TEL+ + GCN ++ + P ++ Sbjct: 8 LKDLIKKQ-YLIIDGATGTELQKKEIKKESWIINGNNIEGCNEILNITA-------PNIM 59 Query: 52 REVHLDYYRAGAQCAITASYQATP-----AGFAARGLDEAQSKALIGKSVELARKAREAY 106 +E+H+DY A A T S+ A P A + + A+S ALI A +ARE Y Sbjct: 60 KEIHIDYLNANANITKTNSFGAIPWVLSEYDIADKTYELAKSAALI------ANEAREEY 113 Query: 107 LAENPQAG-----TLLVAGSVGPYGAYLADGSEYRGD--YHCSVEAFQAFHRPRVEALLD 159 L +NP + + +AGS+GP G L + D Y+ EA V L+D Sbjct: 114 L-KNPNSKGDLNRDIFIAGSLGP-GVKLPSLGQISFDEMYNGYTEA--------VRGLID 163 Query: 160 AGADLLACETLPNFSEIEA--LAELLTAYPRAR---AWFSFTLRDSEHLSDGTPLRDVVA 214 G D++ ET + ++++ LA TA + S T+ + GT + Sbjct: 164 GGVDIILLETAQDVLQLKSAILAVNDTAKKLNKEIPIMVSVTIEKEGTMLLGTDIETAYT 223 Query: 215 LLAGYPQVVALGINCIALENTTAALQHLHGL---TVLPLVVYPNSGEHYDAVSKTWHHHG 271 +L+ + ++G+NC A++H+ L + LP+ ++ N+G + K ++ Sbjct: 224 ILSNL-DIFSIGMNCGT--GPDMAMRHIKKLSEISYLPISIHSNAGLPENRGGKAYYSMT 280 Query: 272 EHCAQLADYLPQ-WQAAGARLIGGCCRTTPADIAAL 306 + AD + ++ G IGGCC TTP I AL Sbjct: 281 PE--EFADINSKFFELDGLAFIGGCCGTTPLHINAL 314 >UniRef50_C9SAQ6 Homocysteine S-methyltransferase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SAQ6_VERA1 Length = 355 Score = 81.6 bits (200), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 96/339 (28%), Positives = 142/339 (41%), Gaps = 52/339 (15%) Query: 16 ILLLDGAMATEL-EARGCNLADS--LWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 +L+LDG + T L + G S LWS+ +LV + + + D+ +TA+YQ Sbjct: 9 VLILDGGLGTSLGDKYGVRFDKSTPLWSSHMLVSDQDTLLACQKDFGDVPVDIILTATYQ 68 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREA----YLAENPQAGTLLVAGSVGPYGAY 128 + GFA AQ I ++ ++A AR+A + A G VA SVGPYGA Sbjct: 69 FSIHGFA--NTRTAQFPDGIDRT-KIASYARDAIAIAHSAGKENGGQ--VALSVGPYGAC 123 Query: 129 LADGSEYRGDY---HCSVEAFQAFHRPRVEALLDAGA-----DLLACETLPNFSEI---- 176 + G EY G Y H + E A+H R +AG +A ET+P EI Sbjct: 124 MIPGQEYTGKYDLEHDTPEDLAAWHLERFRIFEEAGGFSSPVSYIAVETMPRLDEIVAAR 183 Query: 177 EALAELLTAYPRARAWFSFTLRDSEH-LSDGTPLRDVV-ALL---AGYPQVVALGINCIA 231 +AL +L W + E L DG + V A+L Q +GINC Sbjct: 184 KALDDLGAKAANTPFWIACVFPGEEMALPDGASISSAVDAMLNPAVARSQPWGIGINCTK 243 Query: 232 LENTTAALQHL-----------HGLTVLPLVVYPN--SGEHYDAVSKTWHHHGEHCAQLA 278 + + H H LV+YP+ GE Y+ ++TW Q A Sbjct: 244 IWKLKELIAHFEAAVADQVQAGHVNEAPALVLYPDGTDGEVYNTTTQTWELPAGGKVQGA 303 Query: 279 DYLPQW----QAAGAR------LIGGCCRTTPADIAALK 307 + Q + A R ++GGCC+ + A +A L+ Sbjct: 304 PWEEQLAEIVRDANTRGKWKQIVVGGCCKASHAHLARLR 342 >UniRef50_A9B073 Methionine synthase n=2 Tax=Bacteria RepID=A9B073_HERA2 Length = 1180 Score = 81.3 bits (199), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 89/323 (27%), Positives = 146/323 (45%), Gaps = 28/323 (8%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLAD----SLWSAK--VLVENPELIREV 54 M+ P A L K+ +L+ DGAM T L+ D + A+ + + P++I ++ Sbjct: 1 MTSIKPYIAELAKR-VLIYDGAMGTSLDLYDLKPEDFGGEQYFGARDYLALTRPDIIEQI 59 Query: 55 HLDYYRAGAQCAITASYQATPAGFAARGL-DEAQSKALIGKSVELARKAREAYLAENPQA 113 H + AG T ++Q+T GL D+ + K+ +LARK + Y A++ + Sbjct: 60 HSSFMEAGVDVLETNTFQSTRIRLHEWGLADKTYEQNF--KAAQLARKVADRYQAQDGR- 116 Query: 114 GTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNF 173 VAGS+GP G S+ + + +A + + AL++ G D+L ET + Sbjct: 117 -KRFVAGSMGPTG--FLPSSDDPTLSNITWDALSDTFKEQTIALVEGGVDVLLVETSVDI 173 Query: 174 SEIEA--------LAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVAL 225 E++A LAEL P L S + GT ++ + L V + Sbjct: 174 LEVKAAIDGIRRGLAEL--KRPDIAIQAQVFLDLSGRMLLGTDIQATMVTLEALADVDVI 231 Query: 226 GINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW 284 G+NC E+ A+ +L + LP+ PN+G + +T A A L ++ Sbjct: 232 GLNCSTGPEHMRPAITYLAANSKLPISCIPNAGLPMEVNGETVFPL--EPAGFAKSLTEF 289 Query: 285 -QAAGARLIGGCCRTTPADIAAL 306 Q G R++GGCC TTPA + AL Sbjct: 290 VQDLGVRVVGGCCGTTPAHLRAL 312 >UniRef50_A5IKF3 Methionine synthase (B12-dependent) n=6 Tax=Thermotogaceae RepID=A5IKF3_THEP1 Length = 768 Score = 80.1 bits (196), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 82/302 (27%), Positives = 129/302 (42%), Gaps = 38/302 (12%) Query: 14 QDILLLDGAMATELEARGCN-LADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 + +LLLDGA TE G + L + L ++ P+++ +VH Y +G+ +T ++ Sbjct: 13 ERVLLLDGAYGTEFMKYGYDDLPEELN-----IKAPDVVLKVHRSYIESGSDVILTNTFG 67 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 AT GL E + ++ +V +AR+A AG LV G +GP G Sbjct: 68 ATRMKLRKHGL-EDKLDPIVRNAVRIARRA----------AGEKLVFGDIGPTGEL---- 112 Query: 133 SEYRGDYHCSVEAFQAFH---RPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRA 189 Y F+ F+ R V+ +++ G D + ET + E++ A +L A + Sbjct: 113 -----PYPLGNTLFEEFYENFRETVKIMVEEGVDGIIFETFSDILELK--AAVLAAREVS 165 Query: 190 RAWF---SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGL 245 R F T + GT + A+ V ALGINC + E Q L Sbjct: 166 RDVFLIAHMTFDEKGRSLTGTDPAN-FAITFDELDVDALGINCSLGPEEILPIFQELSQY 224 Query: 246 TVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAA 305 T LVV PN+G+ KT + H A ++ + G + GGCC TTP + Sbjct: 225 TDKFLVVEPNAGKPIVENGKTVYPLKPH--DFAVHIDSYYELGVNIFGGCCGTTPEHVKL 282 Query: 306 LK 307 + Sbjct: 283 FR 284 >UniRef50_B9MN08 Homocysteine S-methyltransferase n=1 Tax=Anaerocellum thermophilum DSM 6725 RepID=B9MN08_ANATD Length = 413 Score = 79.0 bits (193), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 80/306 (26%), Positives = 131/306 (42%), Gaps = 44/306 (14%) Query: 16 ILLLDGAMATELEARGCNLAD--SLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 +L+ DGAM T+L G + LWS V +++ +H Y+ AG+ C T ++ A Sbjct: 12 VLIFDGAMGTQLIQNGLTEDECPDLWS----VTRQDVVSSIHRQYFEAGSDCVETNTFGA 67 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 GL E + + + +V+LA++ + Y V SVGP G Sbjct: 68 NREKLKKYGL-ENEVENINKCAVKLAKEVAKEYSG--------YVGLSVGPTGRLFIPSG 118 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRAR--- 190 + D EA F+ ++ + ++AGAD ++ ET+ + E +A AY +A+ Sbjct: 119 DLSFD-----EAESIFYE-QILSGIEAGADFVSIETMSDIKEAKAA---FFAYKKAKEEL 169 Query: 191 -----AWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC----IALENTTAALQH 241 S T ++ L GTP +V A +G NC I L ++ Sbjct: 170 KKDIPCLISLTFEQNKRLLMGTP-PEVAAYYFSSIGCDIVGANCSGGAIQL---LEIIKQ 225 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCA-QLADYLPQWQAAGARLIGGCCRTTP 300 + + +PL V PN+G KT + E C + + ++ G RL GGCC T P Sbjct: 226 MQFFSFVPLSVKPNAGLPKVVDGKTIY---ESCIPEFVNLADEFVENGVRLYGGCCGTNP 282 Query: 301 ADIAAL 306 I ++ Sbjct: 283 EYIKSI 288 >UniRef50_C9KQD5 Vitamin B12-dependent methionine synthase family protein n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KQD5_9FIRM Length = 815 Score = 78.2 bits (191), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 87/298 (29%), Positives = 133/298 (44%), Gaps = 29/298 (9%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 I + DGAM T L+A G L + +++PE++R +H Y AGA T ++ A+ Sbjct: 25 IHIFDGAMGTMLQAGG--LEAGGCPELMNIDHPEVVRHIHEAYIEAGATIIETNTFGASR 82 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGT-LLVAGSVGPYGAYLADGSE 134 GL E + + L +V +A++A AGT VAGS+GP G +++ + Sbjct: 83 LKLDHYGL-EDRVEELNTAAVRIAKEA----------AGTRAKVAGSMGPTGRFISPLGD 131 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA-LAELLTAYPRARAWF 193 D+ EA+ F + + AL AG D ET + E+ A L P Sbjct: 132 L--DFE---EAYACF-KEQASALAKAGVDFFIIETCIDIQEMRAALLASKEVAPAIPVIC 185 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLVV 252 T D GT + +L+ + +G+NC + E ++ L P+ V Sbjct: 186 QLTYSDDGRTVTGTDPQSAAIILSHMGADI-IGVNCSLGPEQLVPIVKTLAASCDCPISV 244 Query: 253 YPNSG--EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 PN+G + D V+ H + P+ AAGA +GGCC TTPA I AL+A Sbjct: 245 QPNAGMPQLVDGVT----HFPMGPEDFGSWGPKLLAAGATYLGGCCGTTPAHIRALRA 298 >UniRef50_C0QE32 Methionine synthase I, cobalamin-binding domain protein n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QE32_DESAH Length = 294 Score = 78.2 bits (191), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 88/302 (29%), Positives = 132/302 (43%), Gaps = 31/302 (10%) Query: 17 LLLDGAMATELEARGCNLADS--LWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 LL DG M + L ARG D+ W+ + PE I+EVH YY+AGA A T ++ A+ Sbjct: 12 LLFDGGMGSMLIARGLQGGDAPERWN----LTRPEAIQEVHQAYYKAGADMATTNTFGAS 67 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 A + E + + V++A+ A+E + P +AG +G G LA Sbjct: 68 AIKLAKMAVTEGMEE-INRAGVKVAKDAKEVW---GPGK---FIAGDIGEAGDMLAPMGP 120 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL-----LTAYPRA 189 S E QA + + E L AG D+ ET F ALA + +T P A Sbjct: 121 L------SQEDAQACFKEQAEVLAHAGVDIFIIET--QFDLNMALAAIRGIRSVTDIPIA 172 Query: 190 -RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTV- 247 F T + + G P + + LAG V +G NC +T L + V Sbjct: 173 CTMTFKQTPKGFFTIM-GNPPAESMKTLAGEGAFV-VGANCSMGSDTMVELAGVIRDAVD 230 Query: 248 LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 P+++ PN+G +T + E AD + + ++ G ++GGCC TTP I + Sbjct: 231 TPVMIQPNAGMPQAGPDQTVTYP-ETADFFADNIMKMKSLGIEVVGGCCGTTPDYIRTIH 289 Query: 308 AR 309 R Sbjct: 290 DR 291 >UniRef50_Q04898 Putative uncharacterized protein YMR321C n=2 Tax=Saccharomyces cerevisiae RepID=YM99_YEAST Length = 105 Score = 78.2 bits (191), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 36/90 (40%), Positives = 52/90 (57%), Gaps = 1/90 (1%) Query: 220 PQVVALGINCIALENTTAALQHLH-GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLA 278 P + LGINC++ + L+ LH L + L+ YPNSGE YD K W + + Sbjct: 10 PNLSFLGINCVSFNQSPDILESLHQALPNMALLAYPNSGEVYDTEKKIWLPNSDKLNSWD 69 Query: 279 DYLPQWQAAGARLIGGCCRTTPADIAALKA 308 + Q+ ++GAR+IGGCCRT+P DI + A Sbjct: 70 TVVKQYISSGARIIGGCCRTSPKDIQEISA 99 >UniRef50_Q4GZ92 Homocysteine S-methyltransferase, putative n=2 Tax=Trypanosoma brucei RepID=Q4GZ92_9TRYP Length = 433 Score = 78.2 bits (191), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 101/412 (24%), Positives = 157/412 (38%), Gaps = 119/412 (28%) Query: 14 QDILLLDGAMATELEARGCNLAD--SLWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 Q +DGA+ T +E G + + S+WS L+ + E++R VH Y GA +T +Y Sbjct: 22 QHFFTMDGAVGTLVERCGLDPSKMGSMWSTSALITDEEIVRYVHKSYLDVGADVILTNTY 81 Query: 72 QATPAGFAARG--LDEAQSKAL----IGKSVELARKAREAYL------------------ 107 Q AG A G ++E + A+ G + E A +EA + Sbjct: 82 QMHAAGCAQAGVTMNEVVNTAVRVLCDGITPERAAATKEAKVWAQHVMNNKRSEFVNVFA 141 Query: 108 ------AENPQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLD-- 159 ++ +LV GS+G YGA L + EYRG+Y + + + ++ R A ++ Sbjct: 142 PLFYGPRDDASKCPVLVGGSLGSYGASLGNAQEYRGEYEVNEDIIRDYYVGRFMAFVNHV 201 Query: 160 ------AGADLLACETLPNFSE-IEALA--------ELLTAYPRARAWFS--------FT 196 D + ET+P +E IE E L + P ++ S T Sbjct: 202 DEKEAHLKVDFIMIETIPLLNEAIEIFTWLKYQKEDETLRSAPVCLSFISCLREPRPDVT 261 Query: 197 LRDSE------------HLSDGTPLRDVVALLA--GYPQVVALGINCIA-LENTTAALQH 241 + D+ L DG L PQ+V G NC + LE + A Sbjct: 262 VDDATLNEWWLAAESNIRLIDGNTFEKAFNSLMELQLPQLVGFGTNCCSPLEASVVASAF 321 Query: 242 L----HGLT--VLPLVVYPNSGEHYDAVSKTWHHHGE-------HCAQLADYLP------ 282 L H +T L L +Y NSGE++ WH G+ + + LP Sbjct: 322 LKKKKHKVTDPSLALFLYSNSGENFK--EGEWHWGGQLPRGSHSPTSSPKETLPFTTLQR 379 Query: 283 ---------------QWQAAGAR-----------LIGGCCRTTPADIAALKA 308 +Q R + GGCCR+TP DIA +++ Sbjct: 380 LMLCCEADVRTAAFFAYQLLLQRPEADDWLFDIIICGGCCRSTPEDIAMIRS 431 >UniRef50_A6TTI3 Homocysteine S-methyltransferase n=6 Tax=Firmicutes RepID=A6TTI3_ALKMQ Length = 789 Score = 77.4 bits (189), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 83/311 (26%), Positives = 139/311 (44%), Gaps = 56/311 (18%) Query: 13 KQDILLLDGAMATELEARGCNLA--DSLWSAKVLVENPELIREVHLDYYRAGAQCAITAS 70 K+ +L+ DGAM T L+ G + +++ +E+PELI+++H + RAGAQ T + Sbjct: 8 KEGMLIFDGAMGTMLQKSGLKVGALPEIYN----IEHPELIQQIHERFVRAGAQVVTTNT 63 Query: 71 YQATPAGF--AARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 +QA + L+E +I +++A+ + Y VA +GP G Sbjct: 64 FQANELKLKDSIYSLEE-----IIEGGIKVAKASGAPY-----------VALDIGPLGQM 107 Query: 129 LADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPR 188 + E D A+ F R +V+A + AGAD + ET+ + EA A +L A Sbjct: 108 MKPLGEISFD-----RAYDIFKR-QVQAGVKAGADCILIETISDLY--EAKAAILAAKEN 159 Query: 189 AR--AWFSFTLRDSEHLSDGT-PLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHG 244 + + T ++ GT P+ + L + V ALG+NC + + L + Sbjct: 160 SDLPVLCTMTFQEDGRTFTGTDPMTATLVLQS--LGVDALGVNCSLGPKEMLPILSDILK 217 Query: 245 LTVLPLVVYPNSG--------EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCC 296 +P++V N+G + A + + +G A+L G ++GGCC Sbjct: 218 YAKVPVMVQSNAGLPRLEGDDTIFPASPEEFALYGREMAEL----------GVGILGGCC 267 Query: 297 RTTPADIAALK 307 TTP I ALK Sbjct: 268 GTTPEHIQALK 278 >UniRef50_C1SMZ8 5-methyltetrahydrofolate--homocysteine methyltransferase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SMZ8_9BACT Length = 1116 Score = 77.4 bits (189), Expect = 6e-13, Method: Composition-based stats. Identities = 87/316 (27%), Positives = 138/316 (43%), Gaps = 50/316 (15%) Query: 13 KQDILLLDGAMATELEARGCNLADSLW------SAKVLVENPELIREVHLDYYRAGAQCA 66 K I+L DGAM T ++ + D +W S + V PE+I+++H Y+ AGA Sbjct: 7 KNRIILFDGAMGTSIQ--NYEITDEIWQGYNGCSEWLNVAAPEIIQQIHEQYFEAGADVV 64 Query: 67 ITASYQATPAGFAARGL-DEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY 125 T ++ T + L D L+G ++AR+A + Y AGS+GP Sbjct: 65 ETNTFGGTELVMSEYDLQDRTYELNLLG--AQIARRAADKY--------GKYTAGSIGP- 113 Query: 126 GAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE-ALAELLT 184 G++ S + + + EALL+ G DL ET + +I+ AL ++ Sbjct: 114 ------GTKLPSLGQISYDDLYTMYHSQAEALLEGGVDLFIIETCQDLLQIKSALNAVID 167 Query: 185 AYPR----ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIA----LENTT 236 A S T+ + + GT + V LL YP V +LG+NC + N Sbjct: 168 VKAEKNSDAPVMVSITVEQNGTMLMGTDISAAVTLLREYP-VFSLGLNCSTGPDLMHNPI 226 Query: 237 AAL-QHLHG-LTVLPLVVYP-NSGEH--YDAVSKTWHHHGEHCAQLADYLPQWQAAGARL 291 L Q+ +G ++ +P P N G YD + A++ + + Q G + Sbjct: 227 NDLAQNFNGRISCIPNAGLPENRGGQMVYDMTP-------DKMAKIVEGMVQEFPIG--V 277 Query: 292 IGGCCRTTPADIAALK 307 +GGCC TTP I AL+ Sbjct: 278 LGGCCGTTPEHIKALR 293 >UniRef50_A4EBI1 Putative uncharacterized protein n=1 Tax=Collinsella aerofaciens ATCC 25986 RepID=A4EBI1_9ACTN Length = 297 Score = 77.0 bits (188), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 82/292 (28%), Positives = 130/292 (44%), Gaps = 37/292 (12%) Query: 13 KQDILLLDGAMATEL--EARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITAS 70 + LL G M + L E ++ + W+ + P+ + +H Y AGAQ IT + Sbjct: 19 SSETLLAQGPMGSVLLSEYDAADIPPAFWN----LAEPQTVSRIHRLYVAAGAQVLITNT 74 Query: 71 YQATPAGFAARGLDEAQSKALIGK-SVELARKAREAYLAENPQAGTLLVAGSVGPYGA-- 127 +QA+ +A + A S A + + +V+ AR+A +PQ L+ GS+GP G Sbjct: 75 FQAS--SYALKHDQIAPSVAEVNRGAVDDARQA-------HPQ----LLLGSMGPIGIEW 121 Query: 128 YLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE-ALAELLTAY 186 + D EYR + R + ALL+AG D L ET+ + ++ LA A Sbjct: 122 FAEDSVEYR--------EIRGIAREQAHALLNAGVDGLLIETVTSIRNLQPMLAGARDAA 173 Query: 187 PRARAWFSFTLRDS-EHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL 245 SF + D + L DG + V L A ++G+NC +L AA+ + Sbjct: 174 DGMPVLVSFVVDDKGDLLGDGLNIEAAV-LYAEKHGANSVGVNCCSLAAANAAVPRMVAS 232 Query: 246 TVLPLVVYPNSGEHYDAVS-KTWHHHGEHCAQLADYLPQWQAAGARLIGGCC 296 P+ V PN G+ WH + E A+ +W+ AGA ++G CC Sbjct: 233 ATTPVTVRPNVGDPVQTQDGPVWHENPEAFARAC---IEWRHAGAAMVGSCC 281 >UniRef50_Q0TQI2 Homocysteine S-methyltransferase family protein n=9 Tax=Clostridium perfringens RepID=Q0TQI2_CLOP1 Length = 279 Score = 77.0 bits (188), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 77/300 (25%), Positives = 130/300 (43%), Gaps = 37/300 (12%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K +++ DGAM T + G NL D+ S + ++ PELI ++H +Y +GA ++ ++ Sbjct: 7 KNGVIIADGAMGTRIMELGVNLKDT-PSELLNIKKPELIEKIHREYIESGANLILSNTFM 65 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A R + + ++G + +A+KA G LVA +GP Y+ + Sbjct: 66 CNIIN-AKR--NNYNLEEVVGAGIHIAKKAC-------GDGG--LVALDIGPLSYYIEEN 113 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGAD---LLACETLPNFSEIEALAELLTAYPRA 189 +F+ E +++A D L+ ETL + E E + Sbjct: 114 DS----------SFKEIVYENTERIINASKDKFDLVIFETLGSLKEGEFAVKKAKTLTDK 163 Query: 190 RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLP 249 + SFTL + + + ++++V+ L V ALGINC E AL L LP Sbjct: 164 KVICSFTLAYKKDIPN--FIKNMVSTLEPL-GVDALGINCTGYEEILIALDILKENINLP 220 Query: 250 LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAA---GARLIGGCCRTTPADIAAL 306 +++ N G + K + L ++ + A G +IGGCC TTP I A+ Sbjct: 221 IMIKANLG-----IPKKVGEELVYDKTLEEFKNLSKRALEKGVNIIGGCCGTTPEYIRAI 275 >UniRef50_D1BQ67 Homocysteine S-methyltransferase n=4 Tax=Veillonellaceae RepID=D1BQ67_VEIPT Length = 811 Score = 77.0 bits (188), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 80/305 (26%), Positives = 128/305 (41%), Gaps = 41/305 (13%) Query: 18 LLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPAG 77 + DGAM T L+A G L + VE PE+++ +H Y + G+ T ++ A G Sbjct: 3 IFDGAMGTMLQAAG--LEEGYCPELFNVERPEVVKNIHAQYLQHGSDVITTNTFGA--CG 58 Query: 78 FAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYRG 137 D I ++ + A+EA P A +AGS+GP G +L Sbjct: 59 LKLEDYDLQDRVREI--NIAAVKVAKEAIAEVKPSA---RIAGSMGPTGRFLQPLG---- 109 Query: 138 DYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA--LAELLTAYPRARA---- 191 + S + +R + EAL++ G D + ET+ + E+ A LA L + Sbjct: 110 --NMSFDDIYDTYREQAEALIEGGVDFIIIETIIDVQEMRAALLASLDAREAAGKTKEDV 167 Query: 192 ----WFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLT 246 FSF+ D ++ GTP +++ + +GINC + E T ++ + +T Sbjct: 168 QIICQFSFS-EDGRTIT-GTPPAVATSIVEAIGADI-IGINCSLGPEQITPLIKEIASVT 224 Query: 247 VLPLVVYPNSG-----EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 LP+ PN+G T G + D AG +GGCC TTPA Sbjct: 225 NLPISCQPNAGMPQLINKQTVFPLTAEEMGPLMLDIVD-------AGTSYVGGCCGTTPA 277 Query: 302 DIAAL 306 I ++ Sbjct: 278 HIQSI 282 >UniRef50_B8FX16 Homocysteine S-methyltransferase n=2 Tax=Desulfitobacterium hafniense RepID=B8FX16_DESHD Length = 285 Score = 76.6 bits (187), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 84/304 (27%), Positives = 124/304 (40%), Gaps = 34/304 (11%) Query: 10 LLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITA 69 +LDK ++ DGAM T L+ +LA + + PE+I EVH Y +AG+ T Sbjct: 2 ILDKDSYVIFDGAMGTMLQKY--DLAPGQPPEVLNITRPEVIEEVHRKYIKAGSNIITTN 59 Query: 70 SYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY- 128 ++ A G SVE + A AG LVA VGP G Sbjct: 60 TFGAIETKLNGTGY-----------SVE--EVVQSAIAIARRAAGKNLVALDVGPTGELI 106 Query: 129 --LADGS--EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 L D S E Y C ++A A L DL+ ET + +E A Sbjct: 107 EPLGDLSFEEVYDLYACQIKA----------AALTGNVDLVLIETFFDLTEAHAAIRAAK 156 Query: 185 AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLH 243 + +FT + G ++ VV L Y V A+G+NC + + ++ + Sbjct: 157 DHSSLPVICTFTFQQKGRTLMGKDIKTVVTSLEEY-GVDAVGVNCSLGPGEMLSIVETMV 215 Query: 244 GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADI 303 T LP++V PN+G +T + + A Y+ G + GGCC TTP I Sbjct: 216 SSTQLPILVQPNAGLPKLIGDRTVYDV--EPEEFARYIQVMANLGVKWFGGCCGTTPEFI 273 Query: 304 AALK 307 +A+K Sbjct: 274 SAIK 277 >UniRef50_C0D4W7 Putative uncharacterized protein n=3 Tax=Clostridium RepID=C0D4W7_9CLOT Length = 836 Score = 76.3 bits (186), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 86/314 (27%), Positives = 133/314 (42%), Gaps = 32/314 (10%) Query: 13 KQDILLLDGAMATELEARGCNLAD--SLWSAKVLVENPELIREVHLDYYRAGAQCAITAS 70 +Q L DG + L+A+G + +WS + PE+ ++H DY AGA T + Sbjct: 8 RQRRLFFDGGTGSLLQAQGLKAGELPEVWS----ITRPEVCVKLHRDYLEAGADIIKTNT 63 Query: 71 YQATPAGFAAR-----------GLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVA 119 + A F R GL A A E+ A + +AG +A Sbjct: 64 FGANGLKFKGRENASGAQGPEAGLPAADRPADSYSVDEIVTAAMKNARRAVAEAGHGYIA 123 Query: 120 GSVGPYGAYLADGSEYRGDYHCSVEAFQAFHR-PRVEALLDAGADLLACETLPNFSEIEA 178 +GP G L + D+ +VE ++ R R E GADL+ ET+ + E++A Sbjct: 124 LDLGPTGKLLKPLGDL--DFEAAVELYKEVVRIGRRE-----GADLVLIETMSDSYELKA 176 Query: 179 LAELLTAYPRARAWFSFTLRDSE-HLSDGTPLRDVVALLAGYPQVVALGINC-IALENTT 236 F+ + D + L G + VALL G +V ALGINC + Sbjct: 177 AVLAAKEAGEGLPVFATVVFDGKGKLLTGGNVESTVALLEGL-RVDALGINCGLGPVQMK 235 Query: 237 AALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHH-HGEHCAQLADYLPQWQAAGARLIGGC 295 ++ L ++ LP++V PN+G T + G+ AQ+ + + + GA +GGC Sbjct: 236 GIVEELLKVSSLPVIVNPNAGLPRSENGVTLYDIDGDRFAQVMEEIARM---GACFLGGC 292 Query: 296 CRTTPADIAALKAR 309 C TTP I R Sbjct: 293 CGTTPEHIQKTVGR 306 >UniRef50_B6BT42 Homocysteine S-methyltransferase 4, putative n=1 Tax=Candidatus Pelagibacter sp. HTCC7211 RepID=B6BT42_9RICK Length = 305 Score = 76.3 bits (186), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 82/333 (24%), Positives = 137/333 (41%), Gaps = 70/333 (21%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 ++ LDK +++LDG ELE G + LW+ K +++P+ + +VH +Y ++GA Sbjct: 6 IKKKLDKNSVVILDGGNGGELEQIGAKMDKDLWAGKSAIDDPDKLFQVHENYIKSGADVI 65 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 + +Y TP G E ++ K+V++A KA + E + VAGSV G Sbjct: 66 TSNTYAITPISMKEYGY-EKFTQEWNKKTVDIALKAAASTERE------IAVAGSVSTSG 118 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE-IEALAELLTA 185 ++ D E F ++ L DAG DL+ E + + E +E++ E ++ Sbjct: 119 SW---------DKLTKNEITPGFSE-QLTILSDAGVDLIILEAMTSKDETVESIIE-CSS 167 Query: 186 YPRARAWFSFT--LRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIA-----LENTTAA 238 W S + + + E L+ GY + V N A LEN+ Sbjct: 168 KINLPVWLSISCAMNNEEG-----------KLMHGYQESVT---NSKAQFYDYLENSLLK 213 Query: 239 LQHLHGLTVL----------------------PLVVYPNSGEHYDAVSKTWHHHGEHCAQ 276 LH +L + YPN+G +++ W + Sbjct: 214 FTQLHKGPILVAHSDIKVTSEAVKILKKIHKGSIGAYPNNG-YFE--KPNWKLVDDISP- 269 Query: 277 LADYLPQ---WQAAGARLIGGCCRTTPADIAAL 306 + YL + W GA++IGGCC P I A+ Sbjct: 270 -SSYLEEAKSWVLNGAQIIGGCCGVGPDKIKAI 301 >UniRef50_A7T8D2 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7T8D2_NEMVE Length = 156 Score = 76.3 bits (186), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 50/172 (29%), Positives = 79/172 (45%), Gaps = 41/172 (23%) Query: 137 GDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSFT 196 GD + + +HRP+++AL++ G DLLA ET+P E EAL +LL +P +AW S++ Sbjct: 14 GDIYQHKKNLMDWHRPQIQALVETGLDLLAFETIPAQKEGEALVQLLKEFPGTKAWLSYS 73 Query: 197 LRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYPNS 256 +D H S V A++A A+ ++ Sbjct: 74 CKDGSHTSHNEDF--VSAIMA-------------AVADS--------------------- 97 Query: 257 GEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 + V W G + + YL +W +GA+ IGGCCRT+ DI+ +A Sbjct: 98 ----EQVRYGWQDTG-NVPPVVSYLDEWIDSGAQWIGGCCRTSLTDISETRA 144 >UniRef50_UPI000190A21A homocysteine S-methyltransferase n=2 Tax=Rhizobium etli RepID=UPI000190A21A Length = 303 Score = 76.3 bits (186), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 90/310 (29%), Positives = 136/310 (43%), Gaps = 35/310 (11%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 I +LDG M+ EL G L WSA L+ +P+++REVH ++ AG++ + SY P Sbjct: 4 IRILDGGMSRELLRLGAELKQPEWSALALINSPDIVREVHKEFIEAGSEIIFSNSYALVP 63 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP-YGAYLADGSE 134 + + ALI + LAR+A A++ +LVAGS+ P +G+Y + Sbjct: 64 FHIGEDRFRK-EGAALIRLAGRLAREA-----ADSVTDRKVLVAGSLPPIFGSY--EPQN 115 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 +R E Q + + VE L D+ ETL +E EA+ E + A + W S Sbjct: 116 FR------PERVQDYLKVLVENLAPF-VDIWLGETLSLIAEGEAVREAVAASGKP-FWIS 167 Query: 195 FTLRDSE-HLSDGTP-LRDVVALLAGYPQVVALG-----INCIALENTTAALQ---HLHG 244 FTL D E + G P LR ++ A V+ G NC E AA++ + Sbjct: 168 FTLADDEADIKSGEPKLRSGESVEAAASWAVSSGAEAFLFNCSKPEVMRAAVETAARVFR 227 Query: 245 LTVLPL-------VVYPNSGEHYDAVSKTWHHHGEHCAQL-ADYLPQWQAAGARLIGGCC 296 T P+ + +G H G+ + + + W AGA +IGGCC Sbjct: 228 KTDAPIENRRLCQCLRRGTGAHRPPNEGLHETRGDLNDDVYSRFACSWAEAGATIIGGCC 287 Query: 297 RTTPADIAAL 306 A I L Sbjct: 288 GIGAAHIHRL 297 >UniRef50_A8N5L5 Putative uncharacterized protein n=1 Tax=Coprinopsis cinerea okayama7#130 RepID=A8N5L5_COPC7 Length = 355 Score = 75.9 bits (185), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 93/356 (26%), Positives = 135/356 (37%), Gaps = 70/356 (19%) Query: 11 LDKQDILLLDGAMATELE-ARGCNLADS-LWSAKVLVENPELIREVHLDYYRAGAQCAIT 68 + K I +LDG + T LE G ++ LWS + ++ +P + + H ++ AGA T Sbjct: 1 MPKPKIAILDGGLGTHLENIIGDEVSKGPLWSTQAVISHPLSVLKTHRNFINAGATIIET 60 Query: 69 ASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 A+YQA+ G GL E +++ L+ K+V LA+ E +A S+GP+GA Sbjct: 61 ATYQASLPGLIKSGLQEYEARELMWKAVSLAK--------EAAADSDASIALSLGPFGAT 112 Query: 129 LADGSEYRG---------DYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE---- 175 L E+ G YH QAF EA + L FS+ Sbjct: 113 LRPTQEFEGFYPPPYGPKAYHPEGPNTQAFDSNEAEARAIGALAQFHLDRLLVFSQNSAV 172 Query: 176 ---IEALAELLTAYPR------------------------ARAWFSFTLRDSEHLSDGTP 208 I+ LA PR W SF + P Sbjct: 173 WDSIQYLAFETLLLPREVIAIRKAVGLLRTHLFKEHRSFDKSWWISFVVPSDATNPSVLP 232 Query: 209 LRDVVALLAGYPQVVALGINCIALENTTAA-------LQHLHGLTVLPLVVYPNSGEHYD 261 L AL G+ A+GINC + + L+ L LV+YPN G YD Sbjct: 233 LVSS-ALCEGHDLPSAIGINCTSFGTLLPRTLELCRLVPRFRPLSQLGLVLYPNGGT-YD 290 Query: 262 AVSKTWHHHGEHCAQ---------LADYLPQWQAAGAR--LIGGCCRTTPADIAAL 306 ++ W + L L + A G R + GGCCRT P+ I+ Sbjct: 291 TTNQRWLPDPVDADRQWGLALRDVLTGVLSETGAEGWRELIAGGCCRTGPSHISQF 346 >UniRef50_C3RK90 Homocysteine S-methyltransferase n=3 Tax=Bacteria RepID=C3RK90_9MOLU Length = 793 Score = 75.9 bits (185), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 79/298 (26%), Positives = 131/298 (43%), Gaps = 24/298 (8%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K DIL+ DGAM T+L+ G D + + +P+LI+ +HL+Y AGA T ++ Sbjct: 16 KNDILVFDGAMGTQLQDAGLKAGD--IPECLNITDPKLIQTIHLNYLNAGADFITTNTFG 73 Query: 73 ATPAGFAARGLDEA--QSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLA 130 A P A EA + +I +++ A AR+ +N L +GP G L Sbjct: 74 ANPLKMA-----EAPYSYEEIINAAIDNATIARKTADRQNDSYIVL----DIGPIGQLLE 124 Query: 131 DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRAR 190 D EA++ + + A A LL ET+ + E++A + Sbjct: 125 PMGTLTFD-----EAYEIIKKQVIIAKDKVDAVLL--ETMTDIYEVKAGILAVKENSDLP 177 Query: 191 AWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLP 249 + + T ++ G +V +L G V LG+NC + T + + +P Sbjct: 178 VFVTMTYENNLRTLSGCDPLTMVNVLEGL-NVDVLGVNCSLGPIELTPIIDQILAAATIP 236 Query: 250 LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 +++ PN+G KT ++ + + + L + G +IGGCC TTP IA+LK Sbjct: 237 VLLQPNAGLPCLVEGKTCYNMDKETF-VQESLKHVKN-GVAIIGGCCGTTPDFIASLK 292 >UniRef50_A3JFK5 Putative uncharacterized protein n=1 Tax=Marinobacter sp. ELB17 RepID=A3JFK5_9ALTE Length = 303 Score = 75.9 bits (185), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 82/295 (27%), Positives = 134/295 (45%), Gaps = 26/295 (8%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 ++LLDG + E+ R N++ +LWS V+ E P+++ VH D+ RAGA+ +Y ATP Sbjct: 4 VVLLDGGLGQEIYRRAANVSSALWSVAVMHEQPDVVTAVHSDFIRAGAKTLSLNTYAATP 63 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 + G E Q A+ + EL +A +A + +AG + P Y Sbjct: 64 SRLLRHGQLE-QLAAIHQNAFELLGQAVKA------TGACVDIAGCLPPLAG------SY 110 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 +G S E + + V+ A AD+L ET+ N E A + + +F Sbjct: 111 QGQPARSFEDLRDEYSVLVKQ--QAVADVLLIETMTNTLEACAACAAASELGKPYG-VAF 167 Query: 196 TLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLV-VYP 254 L L G L + VA ++ Y A+ +NC E +AA+ L + + P V Y Sbjct: 168 RLEADGKLMSGETLAEAVAAVSPYSP-TAVMLNCCDPELISAAMPEL--VRLHPCVGGYA 224 Query: 255 NSGEHYDAVSKTWHHHG-EHCAQLAD-----YLPQWQAAGARLIGGCCRTTPADI 303 N+ + +A+++ E A ++ ++ QW GA +IGGCC TP + Sbjct: 225 NAFKSVEALAQGGSVDALEARADISPQAYVAHVRQWLDDGATVIGGCCEITPEHV 279 >UniRef50_Q65V50 MHT1 protein n=3 Tax=Pasteurellaceae RepID=Q65V50_MANSM Length = 298 Score = 75.5 bits (184), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 87/299 (29%), Positives = 121/299 (40%), Gaps = 36/299 (12%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 I +LDG M+ EL R WSA L E P ++ VH D+ GA+ T SY P Sbjct: 3 ITILDGGMSRELMRRNAPFRQPEWSACALYEEPSAVQAVHEDFIAHGAEVITTDSYAVVP 62 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP-YGAYLADGSE 134 + K L + LA+ A +N T +AGS+ P +G+Y AD Sbjct: 63 FHIGEQRF-HTDGKTLADLAGRLAKSA-----VKNSGVLTTKIAGSLPPMFGSYRAD--- 113 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 E F +P ++ L D+ CET E ++ LL R W S Sbjct: 114 -----LIQPERFAEIAQPLIDG-LSPYVDIWLCETQSAIIEPVSIKALLPKDDRP-FWVS 166 Query: 195 FTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI------------ALENTTAALQHL 242 FTL D E L+ LR + + ++V LG++ I AL TTA L L Sbjct: 167 FTLTDDE-LTCEPQLRSGETVKSAVEKMVDLGVDAILFNCCQPEVIGEALAVTTATLTAL 225 Query: 243 HGLTVLPLVVYPN--SGEHYDAVSKTWHHHGEHCAQLADYL---PQWQAAGARLIGGCC 296 + T + Y N + + DA + YL +W A GA +IGGCC Sbjct: 226 NA-THIQTGAYANAFAPQPKDATANDGLDEVRKDLDPPAYLAWAKKWTAQGASIIGGCC 283 >UniRef50_C1EAX2 Predicted protein n=36 Tax=cellular organisms RepID=C1EAX2_9CHLO Length = 1378 Score = 75.5 bits (184), Expect = 2e-12, Method: Composition-based stats. Identities = 79/321 (24%), Positives = 137/321 (42%), Gaps = 37/321 (11%) Query: 13 KQDILLLDGAMATELEA--------RGCNLADSLWSAK-----VLVENPELIREVHLDYY 59 K+ I+++DGAM T ++ RG + K +++ P++I E+H Y Sbjct: 124 KERIMVIDGAMGTAVQKYKLSEDDFRGERYKNHTHDLKGNNDVLVITRPDVIEEIHTAYL 183 Query: 60 RAGAQCAITASYQATPAGFAARGLDEAQSKALIGKS-VELARKAREAYLAENPQAGTLLV 118 AGA T ++ +T A LD+ + L+ K+ +LA+K + +NP A Sbjct: 184 AAGADIIETNTFNSTMISQADYELDKKEEVYLLNKTAAQLAKKCCVEFTKKNP-AKPRFA 242 Query: 119 AGSVGPYGAYLA-----DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNF 173 AG+VGP L+ + +RG C+ + + +VEAL+D G D+L ET+ F Sbjct: 243 AGAVGPTNKTLSVSPSVENPAFRG---CTYDEIVEAYYEQVEALIDGGVDVLLVETI--F 297 Query: 174 SEIEALAELLTAYPRARAW-------FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALG 226 + A A + W S T+ D+ + + + + +A+G Sbjct: 298 DTLNAKAAMFAIDMYFEKWGQKIPVFVSGTIVDNSGRTLSGQTNEAFWNSMSHSKPIAIG 357 Query: 227 INC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ 285 +NC + ++ +++L + + YPN+G + G A+ P+ Sbjct: 358 LNCALGAKDMVPYIENLSRVADCWVFCYPNAG--LPNAMGGYDQKGAEMAEDCRVFPEKG 415 Query: 286 AAGARLIGGCCRTTPADIAAL 306 A IGGCC TT I L Sbjct: 416 LINA--IGGCCGTTDEHIKCL 434 >UniRef50_A8SPV0 Methylenetetrahydrofolate reductase n=2 Tax=Clostridiales RepID=A8SPV0_9FIRM Length = 606 Score = 75.5 bits (184), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 81/309 (26%), Positives = 134/309 (43%), Gaps = 29/309 (9%) Query: 5 NPLRALLDKQDILLLDGAMAT---ELEARGCNLADSLWSAKVLVENPELIREVHLDYYRA 61 N L +L DK +L+ DGA T + +A L + + +PE + E+H +Y +A Sbjct: 2 NILESLRDK--LLVADGAFGTCYAGMYGERGTVAPELANMR----HPERVLEIHKEYVKA 55 Query: 62 GAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGS 121 GA T ++ A A A +D S + +V+LA++A A VAG Sbjct: 56 GAGIIRTNTFAANTASLDA-DMDYVISN--VRAAVKLAKQAVAETGAPGIDRKKAYVAGD 112 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 +GP A D ++ + ++ EA+ D G D++ ET P F+ +E + + Sbjct: 113 IGPIPA----------DAGLTLNERVSQYKLLGEAMQDMGVDIIWFETFPEFNVLEPVVK 162 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQH 241 L A SF + + + G R +++ A V +G+NC LQ Sbjct: 163 QLKARKDTPVMVSFCVNQFGYSNCGFSARALLSQAAANSDVDCVGLNCGV--GPYHMLQL 220 Query: 242 LHGLTV---LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRT 298 L L + P+ + PN+G Y +++ ++ D + A GA +IGGCC T Sbjct: 221 LKKLDIDCGKPVSIMPNAG--YPKFTQSRLVFNDNKEGFIDKIQDIAALGADIIGGCCGT 278 Query: 299 TPADIAALK 307 P I +K Sbjct: 279 NPEYIRQIK 287 >UniRef50_UPI0001BCEC92 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein n=1 Tax=Selenomonas noxia ATCC 43541 RepID=UPI0001BCEC92 Length = 597 Score = 75.1 bits (183), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 82/314 (26%), Positives = 125/314 (39%), Gaps = 43/314 (13%) Query: 1 MSQNNPLRALLDKQDILLLDGAMAT------ELEARGCNLADSLWSAKVLVENPELIREV 54 M+QN+ K++ L+ DG M T +G LA+ +E P ++ + Sbjct: 1 MAQNSADIREHIKKEPLVFDGGMGTYYAQKTHTHGKGVELAN--------IETPAVVGAI 52 Query: 55 HLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAG 114 H +Y +AGAQ T ++ A + DE+ + +I E+A +A E Sbjct: 53 HTEYLQAGAQAIKTNTFAANRIVYQG---DESLVRRIIRAGWEIAARAAE---------- 99 Query: 115 TLLVAGSVGPYGAYL-ADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNF 173 P+GAY+ AD G H + A +R + L GA ET + Sbjct: 100 ---------PFGAYVFADIGPVTGLPHTDI---IAEYRFLADTFLACGATHFLFETNASI 147 Query: 174 SE-IEALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIAL 232 IE A + P A SF+ + DG D++ A + A+G NC+ Sbjct: 148 EGLIETAAHIKRICPHAFILASFSALPGGYTRDGRFAEDLIHEAAESGSIDAVGFNCVNG 207 Query: 233 ENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLI 292 L H G+T LPL + PN+G +T++ L G ++ Sbjct: 208 VRQMRELGHHLGMTSLPLSLMPNAGHPIVVDGRTFYESAPE--YFGTSLAAIVRDGISIV 265 Query: 293 GGCCRTTPADIAAL 306 GGCC TTP I AL Sbjct: 266 GGCCGTTPEHIRAL 279 >UniRef50_C6LEJ3 Vitamin B12-dependent methionine synthase family protein n=3 Tax=Clostridiales RepID=C6LEJ3_9FIRM Length = 291 Score = 74.7 bits (182), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 81/303 (26%), Positives = 137/303 (45%), Gaps = 33/303 (10%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 +DI++LDGA + L G + + + + ++EN + + E+ Y AG+Q ++ A Sbjct: 11 EDIIILDGATGSNLMKAG--MPRGICTEQWILENEQTLIELQRAYVEAGSQIVCAPTFGA 68 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 AA GL + + + + V+++ +A E G VAG + G +A GS Sbjct: 69 NCRNLAAHGLRDKLAD-MNKRLVDISLRATE---------GRAYVAGDMSTGG--VAIGS 116 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWF 193 Y EAF+ + ++ L++AGADLL ET+ + E A E Sbjct: 117 SPDATYE---EAFERYAE-QITHLVNAGADLLLAETMISIDETVAAVEAAKEICDLPILC 172 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLVV 252 S T+ L G + + L A+GINC + + A + + + +P++ Sbjct: 173 SMTVEADGSLYFGGSALEALETLQEV-GASAVGINCSVGPDQLEAVIAEMKKIARVPVIA 231 Query: 253 YPNSG-----EHYDAV-SKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 PN+G E +A+ S T G+H +L + AGA ++GGCC TTP I + Sbjct: 232 KPNAGMPKITEKGEALYSMTPEDFGKHMERLVE-------AGAGIVGGCCGTTPEYIREM 284 Query: 307 KAR 309 +R Sbjct: 285 CSR 287 >UniRef50_UPI0001BC6543 5-methyltetrahydrofolate--homocysteine methyltransferase n=2 Tax=Fusobacterium RepID=UPI0001BC6543 Length = 290 Score = 74.7 bits (182), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 83/301 (27%), Positives = 133/301 (44%), Gaps = 48/301 (15%) Query: 13 KQDILLLDGAMATELEARG---CNLADSLWSAKVLVENPE-LIREVHLDYYRAGAQCAIT 68 K+ IL+LDGAM T L + G C +VL + E LI+++H Y AGA T Sbjct: 7 KRRILVLDGAMGTMLASYGEKPC--------YEVLNKTKENLIQKIHEKYIEAGADIITT 58 Query: 69 ASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 S+ L E+ L KSVE+A+KA +N + ++ GS+GP A Sbjct: 59 NSFNCNQMALQKYHLKESVYD-LTKKSVEIAKKA-----TKNSKKAVYIL-GSIGPSIAN 111 Query: 129 LADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE----IEALAELLT 184 L + +++++ + ++ LLD G D L ET+ + ++ + + E+L Sbjct: 112 LPE----------DMKSWKQSYFQQILGLLDGGVDALLLETIYDENKANCILGIIEEVLQ 161 Query: 185 AYPRARAWF-SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHL 242 A R F S T+ + L GT + V + P +V G+NC +EN + L L Sbjct: 162 AGKREIPVFCSMTINQNGKLLTGTSITRAVEKM-DRPWIVGFGLNCSYGMENVVSFLPEL 220 Query: 243 HGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYL----PQWQAAGARLIGGCCRT 298 T +VY N+G + GE+ + + L P + ++GGCC T Sbjct: 221 IWATDKYCMVYANAGFP--------NEKGEYTENIEEMLELLQPFLEKHLIHIVGGCCGT 272 Query: 299 T 299 Sbjct: 273 N 273 >UniRef50_Q024B4 Homocysteine S-methyltransferase n=2 Tax=Bacteria RepID=Q024B4_SOLUE Length = 304 Score = 74.7 bits (182), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 92/324 (28%), Positives = 142/324 (43%), Gaps = 51/324 (15%) Query: 4 NNPLRALLDKQDILLLDGAMATELEARGCNLAD--SLWSAKVLVENPELIREVHLDYYRA 61 N PL+ ++ ++ LL DGAM T+L G + LW+ + +PE + + Y A Sbjct: 2 NEPLQDVIRRRP-LLGDGAMGTQLMFAGLEQGNCGELWN----LTHPERVLGIQRRYAEA 56 Query: 62 GAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKARE-AYLAENPQAGTLLVAG 120 G+ C +T ++ + G GK VE+ R A E A A +AG V G Sbjct: 57 GSDCILTNTFGGSRIMLNRHGSS--------GKVVEINRAAVEIAREAFGGRAG--YVIG 106 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE----I 176 +GP+G + + GD+ + E ++ + AL+DAGAD + ET + E I Sbjct: 107 DIGPFGGLM----QPYGDF--TEEDVRSAFGEQAGALVDAGADAIIIETQTSLEELQLGI 160 Query: 177 EALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVAL----LAGYPQ-----VVALGI 227 EA E + TL DG+ R ++ + AG+ Q +VAL Sbjct: 161 EAAREAGAPCVIGSMAYDVTL-------DGSTFRTMMGVDPERAAGFMQEHDADIVAL-- 211 Query: 228 NC---IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW 284 NC + + A+ T LP++V PN+G K + E Q+A + Sbjct: 212 NCGTGMDMARAREAVLRYRKATDLPVMVQPNAGVPKLISMKVVYD--ETPEQMASGVAPL 269 Query: 285 QAAGARLIGGCCRTTPADIAALKA 308 AGA +IG CC +TP I A +A Sbjct: 270 LCAGANIIGACCGSTPEHIRAFRA 293 >UniRef50_A8M0Q1 Homocysteine S-methyltransferase n=3 Tax=Actinomycetales RepID=A8M0Q1_SALAI Length = 307 Score = 73.9 bits (180), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 87/309 (28%), Positives = 124/309 (40%), Gaps = 41/309 (13%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVL--VENPELIREVHLDYYRAGAQCAITASYQAT 74 L+LDG + TEL+ RG ++ W+A L + LI ++H +Y AGA +++ T Sbjct: 10 LILDGGLGTELQRRGRSVTAPWWTAHCLRDADGRRLIAQIHAEYVTAGADVITADTFRTT 69 Query: 75 PAGFAARGL-DEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 P G+ + L+ +V LAR+A + +LVAGSV P Sbjct: 70 PRAAHRAGIAGHTVAADLVRTAVALAREAADTVRRR------VLVAGSVAPV------ED 117 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA--YPRARA 191 YR D + + H E L DL+ ET+ E A + A P A Sbjct: 118 CYRPDLVPNDGVLRREHAWLAEQLARTSVDLVLVETMNTAREAVAATRAVCAEGLP---A 174 Query: 192 WFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLV 251 W SF + L GT + A + + L +NC T AL+ L V PL Sbjct: 175 WVSFVCTNDARLLSGTDVVAAAAAVRAAGADMVL-VNCTDPAGTDGALRRLRRPDVGPLG 233 Query: 252 VYPN-----------SGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 YPN + + Y T E CA YL ++GGCC +TP Sbjct: 234 AYPNLEDRRGLPPAAAVDRYLPPRLTPDAFAELCAGWY-YLD--------VVGGCCGSTP 284 Query: 301 ADIAALKAR 309 IA L+ R Sbjct: 285 THIATLRGR 293 >UniRef50_C7NB07 Methionine synthase n=6 Tax=Leptotrichia RepID=C7NB07_LEPBD Length = 1169 Score = 73.6 bits (179), Expect = 8e-12, Method: Composition-based stats. Identities = 83/322 (25%), Positives = 134/322 (41%), Gaps = 48/322 (14%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAK-------VLVENPELIREVHLDYYRAGAQC 65 K ILLLDGAM T ++ AD K ++++ P++I+ +H Y AG+ Sbjct: 18 KNKILLLDGAMGTMIQQENLT-ADDFGGEKYEGCNDYLVLQRPDVIKNIHKKYLEAGSDI 76 Query: 66 AITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAG-TLLVAGSVGP 124 T S+ A L++ + + K+ EL +A Y +E+P+ L VAG++GP Sbjct: 77 IETNSFGALDIVLKDYDLEDTVFE-MNKKAAELVNEAIAEYRSEHPEVTRNLYVAGALGP 135 Query: 125 YGAYLA--DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA---- 178 ++ G + H A V L+ G DL+ ET+ + ++A Sbjct: 136 SNKSISVTGGVTFEELIHTYYTA--------VSGLMAGGVDLILFETIQDTRNLKAAYLG 187 Query: 179 LAELLTAYPRARAWFSFTLRDSEHLSDGTPLR----DVVALLAGYPQVVALGINC-IALE 233 L + + SFT+ S GT L D + ++G+NC E Sbjct: 188 LKKAMEENYTVPLMLSFTIE-----STGTTLAGQTADAFYYAVNHMNPFSVGLNCATGPE 242 Query: 234 NTTAALQHLHGLTVLPLVVYPNSG-----EHYDAVSKTWHHHGEHCAQLADYLPQWQAAG 288 T L+ L+ ++ + VYPN+G Y+ T A P +Q Sbjct: 243 FMTQFLKTLNNISNTYISVYPNAGLPNEDGEYEETPDTLS---------AKIEPFFQNNY 293 Query: 289 ARLIGGCCRTTPADIAALKARS 310 ++GGCC TTP I +K +S Sbjct: 294 LNIVGGCCGTTPEHIQKIKEKS 315 >UniRef50_Q0AX05 Methionine synthase (B12-dependent) n=1 Tax=Syntrophomonas wolfei subsp. wolfei str. Goettingen RepID=Q0AX05_SYNWW Length = 839 Score = 73.6 bits (179), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 81/298 (27%), Positives = 130/298 (43%), Gaps = 34/298 (11%) Query: 16 ILLLDGAMATELEARGCNLAD--SLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 IL+LDGAM T L+ RG + L+ V NP ++ ++H Y AGA + ++ Sbjct: 13 ILILDGAMGTMLQERGMVPGECPELFG----VNNPLILEDIHYQYMEAGADIIQSNTFGG 68 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 A GL + ++ + +++ +AR G LVA S+GP G L Sbjct: 69 NRFKLAEYGLQDRVAE-INAEAIRIARAGAR---------GKALVAASIGPSGKLLQPFG 118 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALL---DAGADLLACETLPNFSEIEALAELLTAYPRAR 190 D+ E + AF E +L AGADL++ ET+ + E+ A + R Sbjct: 119 --NADF---AELYAAF----TEQMLSCEKAGADLISIETMTDIGEMRAALIAACSNTRLP 169 Query: 191 AWFSFTLRDSEHLSDGT-PLRDVVALLAGYPQVVALGINCIA-LENTTAALQHLHGLTVL 248 T GT PL ++ + A P +A+G NC ++ + + + Sbjct: 170 VIAHMTFEPGGRTLMGTDPLTALIIMEALQP--LAIGANCSGGARELLPIIEEMGRYSSV 227 Query: 249 PLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 L V PN+G +T + ++A+Y + + GA +IGGCC TTP I A+ Sbjct: 228 FLSVEPNAGLPQLLGERTVFP--DRPEEMAEYALKLRDVGANIIGGCCGTTPEHIKAI 283 >UniRef50_O06745 5,10-methylenetetrahydrofolate reductase n=78 Tax=Bacillus RepID=YITJ_BACSU Length = 612 Score = 73.6 bits (179), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 80/299 (26%), Positives = 133/299 (44%), Gaps = 35/299 (11%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 ++ +L+ DGAM T L + G D + ++ + PE I+ +H Y AGA T +Y Sbjct: 8 QRQVLIGDGAMGTLLYSYGI---DRCFE-ELNISKPEEIQRIHKAYVEAGANIIQTNTYG 63 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A + GL E K + ++V++AR + AG V G++G G + Sbjct: 64 ANYIKLSRHGL-EDDIKKMNQEAVKIARAS----------AGDAYVLGTMG--GIRTFNK 110 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 + Y S++ + R ++ LL D L ET + E + ++ Sbjct: 111 NAY------SLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETDLPIM 164 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLV 251 + ++ + L DGTPL D + +A + +GINC + + AL + + L Sbjct: 165 LNVSMHEQGVLQDGTPLSDALRSIADLGADI-VGINCRLGPYHMIEALSEVPIFDDVFLS 223 Query: 252 VYPNSG----EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 VYPNS E V +T + ++ A +++ GAR+IGGCC TTP I A+ Sbjct: 224 VYPNSSLPSLEEGRLVYETDDTYFQNSAS------EFRKQGARIIGGCCGTTPNHIRAM 276 >UniRef50_A6DGP4 5-methyltetrahydrofolate--homocysteine methyltransferase n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DGP4_9BACT Length = 1204 Score = 73.2 bits (178), Expect = 1e-11, Method: Composition-based stats. Identities = 88/336 (26%), Positives = 151/336 (44%), Gaps = 52/336 (15%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAK--------VLVENPELIRE-VHLDYYRAGA 63 K+ IL+LDGAM + ++ L DS + + ++ P+ +R+ +HL+Y +AGA Sbjct: 8 KEQILVLDGAMGSMVQL--LKLPDSAYGGEEYAMLSDLLVFSRPDQVRDNIHLEYLKAGA 65 Query: 64 QCAITASYQATP-------------AGFA--ARGLD--EAQSKALIG----KSVELARKA 102 T ++ A+P + FA GLD E AL + +ELA+ A Sbjct: 66 NILETNTFGASPLRLQEFDFSKMDLSDFADLPEGLDFLENDYYALTHYFNIRGIELAQDA 125 Query: 103 REAYLAENPQAG-TLLVAGSVGPYGAYLADGSEY--RGDYHCSVEAFQAFHRPRVEALLD 159 E Y + G L VAGS+GP ++ + + D+ + F +V+A++ Sbjct: 126 IEKYKKMDEYDGRPLFVAGSIGPSNWVISSTAANLNKTDFATIKQNFYL----QVKAMMQ 181 Query: 160 AGADLLACETLPNFSEIEA-------LAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDV 212 A D+L ET + E++A AE L A + + + + T + Sbjct: 182 ANVDVLLFETQQDMLELKASIAGAHQAAEELGFKVPIMAQVTVDQFNKMQIFN-TDMEAA 240 Query: 213 VALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHG 271 A + G + GINC + E + L ++ LP+ V PN+G+ +T + Sbjct: 241 YAAVGGI-GIDVFGINCTLGPELMQKVIPALAQMSELPISVVPNAGQPISVNGETVYPLA 299 Query: 272 EHCAQLADYLPQWQAA-GARLIGGCCRTTPADIAAL 306 ++ +Y+ ++A G ++GGCC TTPA IA + Sbjct: 300 PE--KMGEYMRDYEAENGINIVGGCCGTTPAHIAEI 333 >UniRef50_B2A781 Homocysteine S-methyltransferase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A781_NATTJ Length = 793 Score = 72.8 bits (177), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 73/291 (25%), Positives = 134/291 (46%), Gaps = 28/291 (9%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVL-VENPELIREVHLDYYRAGAQCAITASYQ 72 + +L LDG+ TEL+ RG +A++L +++ +L++ VH DY AGA +T ++ Sbjct: 13 EKLLFLDGSYGTELQRRGFE-----GNAEILNLQDQDLVKNVHYDYASAGADLILTNTFG 67 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 G E + + + VELA+++ AEN +LV G + G ++ Sbjct: 68 GNRLKLKDAGY-EDKVAEINSRGVELAKES-----AENIDR-DVLVVGDISSTGRFI--- 117 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE-ALAELLTAYPRARA 191 E GD + +A Q F + L+++G DL+ ET+ + E++ A+ + + Sbjct: 118 -EPVGDLSFT-KAQQVFQE-QGRYLIESGVDLIKIETMTDIKELKAAILGIRSIDEDLPL 174 Query: 192 WFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPL 250 S + GT + V L+ P V +G+NC + ++ ++ ++ PL Sbjct: 175 IVSMSFEQDGKTITGTSVPSYVTLMNDLP-VDIIGLNCGVKSKDMLDLVKQASYYSLKPL 233 Query: 251 VVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG-ARLIGGCCRTTP 300 + PN+G+ +S + E + + YL ++GGCC TTP Sbjct: 234 SISPNAGDPDLDLS-----YSEDPQEFSFYLDAISDLDMVAIVGGCCGTTP 279 >UniRef50_UPI00017B4C9F UPI00017B4C9F related cluster n=1 Tax=Tetraodon nigroviridis RepID=UPI00017B4C9F Length = 1141 Score = 72.8 bits (177), Expect = 2e-11, Method: Composition-based stats. Identities = 89/336 (26%), Positives = 146/336 (43%), Gaps = 56/336 (16%) Query: 7 LRALLDKQDILLLDGAMATELEARG---CNLADSLWS--AKVLVEN--------PELIRE 53 LR +L+++ I++LDG M T ++ CN + + L+ N P+++ + Sbjct: 19 LRGILERR-IMILDGGMGTMIQQHKLEECNFRGDEFKDHPQPLMGNNDLLSLTCPDIVYK 77 Query: 54 VHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQA 113 +H DY AGA T ++ T A GL E + L S ELARKA A++ + Sbjct: 78 IHKDYLLAGADIIETNTFSGTSVAQADYGL-EHMAYRLNKASAELARKA-----ADDVTS 131 Query: 114 GTLL---VAGSVGPYGAYLADGSEYRGDY--HCSVEAFQAFHRPRVEALLDAGADLLACE 168 T + VAG++GP L+ + + + +A + +V+ LLD G D+L E Sbjct: 132 STGVKRYVAGALGPTNKTLSVSPSVEKPHFRNITFDALVEAYTEQVKGLLDGGVDILLVE 191 Query: 169 TLPNFSEIEALAELLT-------AYPRARAWFSFTL--RDSEHLSDGTPLRDVVALLAGY 219 T+ F A A L +Y R + S T+ R LS T VV++ Sbjct: 192 TI--FDTANAKAALFAIDLLFEKSYSRKPIFISGTVVDRSGRTLSGQTVEAFVVSVSHAK 249 Query: 220 PQVVALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHY-------DAVSKTWHHHG 271 P + +G+NC + ++ + T ++ YPN+G + D V T Sbjct: 250 P--LCIGLNCALGATEMRPFIEAIGKCTTAFVICYPNAGNPHLFNQYLSDTVRPT----- 302 Query: 272 EHCAQLADYLPQWQAAG-ARLIGGCCRTTPADIAAL 306 ++ ++ G ++GGCC TTP I AL Sbjct: 303 ----HISFNAKEFSVDGLVNIVGGCCGTTPEHIRAL 334 >UniRef50_Q1NSQ8 Methylenetetrahydrofolate reductase n=3 Tax=Deltaproteobacteria RepID=Q1NSQ8_9DELT Length = 704 Score = 72.4 bits (176), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 86/308 (27%), Positives = 139/308 (45%), Gaps = 39/308 (12%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 ++ ++L DGA+ T L ++G L + ++ + +P+LI +H +Y RAG+Q T ++ Sbjct: 85 QEKVILGDGAIGTYLYSKGIELGKD--TDRLNLSDPDLIYSLHEEYIRAGSQLIETNTFG 142 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A A GL+ + + LA A +A+ + VAGSVGP G Sbjct: 143 ANRLKLLANGLENQ------AREINLA----GAGIAKRAAGEDIYVAGSVGPTGVEFPLE 192 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRAR-- 190 + G+ + A A + ++ ALL+A DLL ET + L ELL A AR Sbjct: 193 A---GEIEPAEVA--AAYEEQISALLEAEVDLLILETFTH------LDELLIALETARRL 241 Query: 191 AWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVA----LGINC-IALENTTAALQHLHGL 245 A + + + G R AL G + A +G NC + + A++ L L Sbjct: 242 APQHPIVAQMAYPAQGRTARGDHALTCGTAAIAAGASLVGANCGRGVNSMLTAIEALSPL 301 Query: 246 T-VLPLVVYPNSGEHYDAVSKTWHHHGEHCAQ---LADYLPQWQAAGARLIGGCCRTTPA 301 +PL +PN+G + H + AQ +A + + GARL+GGCC T+P Sbjct: 302 RDQVPLSAFPNAG-----FPEIVGHRMIYPAQPEYMARVVGEMIKLGARLVGGCCGTSPT 356 Query: 302 DIAALKAR 309 I + + Sbjct: 357 HIQEFRKQ 364 >UniRef50_A7VWF8 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753 RepID=A7VWF8_9CLOT Length = 408 Score = 72.0 bits (175), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 79/297 (26%), Positives = 132/297 (44%), Gaps = 35/297 (11%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 L+LDGA T L A G + + + ++E+PE + + + AG+ + ++ A Sbjct: 9 LILDGATGTNLIAAG--MPSGVCVEQWILEHPEKLLALQRAFLEAGSNAVMAPTFGANRE 66 Query: 77 GFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYR 136 AA GL + Q + + K V L+++A E + A LV G V P G + E Sbjct: 67 KLAAYGLQD-QVEEINLKLVALSKEAAEPFHA--------LVGGDVSPAGVMI----EPY 113 Query: 137 GDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA--LAELLTAYPRARAWFS 194 GD + + + ++ AL AG D +A ET + +++ A LA P + + Sbjct: 114 GD--LTFDELYDIYLEQIRALKKAGVDFIALETQMSLADLRAGVLAAKEAGLP---VFAT 168 Query: 195 FTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-----IALENTTAALQHLHGLTVLP 249 T+ D+ GT V+ L A+G+NC + E A+ H +P Sbjct: 169 ITVEDNGRTIMGTKFLPVLITLQAL-GAAAVGLNCSTGPEVMEELLEGAVSHAQ----VP 223 Query: 250 LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 L+ PN+G+ + A+ A+ + AAGA+++GGCC +TP I L Sbjct: 224 LIAKPNAGKPSQEDPAVYPLSP---AEFAEKMESLLAAGAQIVGGCCGSTPEHIREL 277 >UniRef50_A9A1I5 Homocysteine S-methyltransferase n=2 Tax=Thaumarchaeota RepID=A9A1I5_NITMS Length = 320 Score = 71.6 bits (174), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 84/329 (25%), Positives = 138/329 (41%), Gaps = 43/329 (13%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLAD-----SLWSAKVLVENPELIREVH 55 M++ P L + +LL DGAM TE++ D ++ ++V P+ I+++H Sbjct: 1 MTEKEPFLDALQNR-VLLFDGAMGTEIQKFNPKPEDFPNNQDGFNDGLVVTRPDWIKQIH 59 Query: 56 LDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGT 115 Y AGA C T S+ + G + Q+ K +LA + + Y ++ P+ Sbjct: 60 RHYLDAGADCIETNSFGSNKIKLDEYGFGD-QTIEFNKKIAQLASEVCQEY-SDRPR--- 114 Query: 116 LLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE 175 V GS+GP G + G E +AF + E L+ G D L ET + E Sbjct: 115 -YVIGSMGPSGFLPSSNDPDLGQKPLD-EIKEAFEL-QAEGLILGGVDALLIETSQDILE 171 Query: 176 IEALAE-----LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI 230 ++ + E + + + TL + GT ++ A Y V +GI+ Sbjct: 172 VKLVIEACHQAMEKTGKKIPIIANTTLDQYGKMLLGTNIQ------AAYTTVSDMGIDVF 225 Query: 231 ALENTTAAL-----------QHLHGLTVLPLVVYPNSGEHYDAVSK-TWHHHGEHCAQLA 278 + +T + Q+ H + V+P P + E AV K T G+ L Sbjct: 226 GMNCSTGPIEMTPSVRWLDEQNEHNILVVPNAGMPEN-EGGQAVYKMTPEKMGD---ALG 281 Query: 279 DYLPQWQAAGARLIGGCCRTTPADIAALK 307 D+L Q++ R+IGGCC T P I L+ Sbjct: 282 DFLNQYKK--VRIIGGCCGTNPEHIKVLR 308 >UniRef50_B6GAW1 Putative uncharacterized protein n=1 Tax=Collinsella stercoris DSM 13279 RepID=B6GAW1_9ACTN Length = 848 Score = 71.6 bits (174), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 84/286 (29%), Positives = 119/286 (41%), Gaps = 29/286 (10%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 LL DG M T L+ARG LA + + +PE I +H Y +AG+ T ++ A Sbjct: 15 LLFDGGMGTMLQARG--LAAGELPELLCLTHPEQITAIHQAYVQAGSDVITTNTFGANRL 72 Query: 77 GFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYR 136 A R AQ + + +V AR Q+G LVA +GP GA L Sbjct: 73 KLAGR----AQVRDVFRAAVACAR-----------QSGARLVAADIGPIGALLRPLGTLS 117 Query: 137 GDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSFT 196 D EA+ F + A DAGADL ET+ + EI+A + + T Sbjct: 118 FD-----EAYDLFAE-QAHAAQDAGADLFIIETMTDLLEIKAAVLACREQTDLPIFATMT 171 Query: 197 LRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAAL-QHLHGLTVLPLVVYPN 255 GTP +V A+ V ALGINC L + + +T P++V N Sbjct: 172 FEADGRTFLGTP-PEVAAVTLDALGVDALGINCSQGPAELRPLARRMLAVTEKPVIVQAN 230 Query: 256 SG-EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 +G H + + E AQ + + G ++GGCC T P Sbjct: 231 AGLPHVEDGCTVFDIEPEAYAQAVAGMVE---DGVGILGGCCGTDP 273 >UniRef50_Q6AL45 Related to 5-methyltetrahydrofolate--homocysteine methyltransferase n=1 Tax=Desulfotalea psychrophila RepID=Q6AL45_DESPS Length = 316 Score = 71.2 bits (173), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 75/307 (24%), Positives = 130/307 (42%), Gaps = 31/307 (10%) Query: 14 QDILLLDGAMATELEARGCNLADSLW------SAKVLVENPELIREVHLDYYRAGAQCAI 67 + +L+ DGA T L++ N+A S W + + + PE I E+H + AGA Sbjct: 6 ESLLIFDGACGTTLQSM--NIAPSAWGDLAGCNEFLNISAPEYIIELHKKFLEAGAMVVE 63 Query: 68 TASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGA 127 T ++ A+ GL+ + + E + A++A + +AGS+GP Sbjct: 64 TNTFGASSIVLTEYGLENKVDEI----NREAVKNAKKAISQLKDSSQPRYIAGSIGPTTK 119 Query: 128 YLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE----ALAELL 183 + G H + R +V +LL+AG D L ET + +++ + E+L Sbjct: 120 LPSLG-------HIETKVLAQSIREQVISLLEAGVDALIVETCQDLLQLKTALISCFEIL 172 Query: 184 TAYPRARAWF-SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 P+ S T + GT + V A LA +P + +LG+NC + + +Q+ Sbjct: 173 DVAPKKLPVLASVTFEKQGTMLLGTDIAAVCATLAPFP-LFSLGLNCATGPTDMVSQIQY 231 Query: 242 LHGLTVLPLVVYPNSG--EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 L + PN G E D + E+ + ++ ++ G ++GGCC T Sbjct: 232 LSQTWDKRISCIPNQGMPELKDGKTHYPLSPEEYSQHMLKFVAEY---GVSIVGGCCGTG 288 Query: 300 PADIAAL 306 P I L Sbjct: 289 PEHIRQL 295 >UniRef50_C4GEB4 Methylenetetrahydrofolate reductase n=1 Tax=Shuttleworthia satelles DSM 14600 RepID=C4GEB4_9FIRM Length = 670 Score = 70.9 bits (172), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 86/319 (26%), Positives = 128/319 (40%), Gaps = 37/319 (11%) Query: 13 KQDILLLDGAMATELEAR-GCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 K+ LL DGA T + +S + V V P+ ++ +H Y AGA T ++ Sbjct: 8 KEHTLLFDGAFGTYYTKQFRPEKEESFFPEYVNVSRPDRVKAIHRKYLSAGAHAIKTNTF 67 Query: 72 QATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAE---NPQAGTLLVAGSVGPYGAY 128 A P D ++K LI LA +A +L++ N T A G + Sbjct: 68 GAYPGILMK---DAGETKKLITAGFSLAEEALLNHLSKDVKNRPETTGEFARRAGQERSA 124 Query: 129 LADGSEYRGDYHC-----------SVEAFQAFHRPRVEALLDAGADLLACETLPNFSEI- 176 A G E DY E A+ +++ L+ GA ETLP + Sbjct: 125 EASGEE---DYFIFADLGPAPGEEEKERILAYQMA-IDSFLETGARYFLFETLPEEKTVL 180 Query: 177 EALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTT 236 EA+ L P A SF + S+G RD++A AG V A+G+NC+ Sbjct: 181 EAIRYLKDQCPGAYTISSFAVMPDGFSSEGCNYRDMLAAAAGESAVDAVGLNCM------ 234 Query: 237 AALQHLHGLTV------LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGAR 290 +++ H+ L PL++ PN+G Y V + A L + G Sbjct: 235 SSVWHMDHLIRQIPDPGKPLLLMPNAG--YPVVRGYRTVFEGNADYFARILARDAGQGVA 292 Query: 291 LIGGCCRTTPADIAALKAR 309 ++GGCC TTP I L R Sbjct: 293 MVGGCCGTTPDHIRLLADR 311 >UniRef50_D2RMA2 Homocysteine S-methyltransferase n=13 Tax=Bacteria RepID=D2RMA2_ACIFE Length = 805 Score = 70.5 bits (171), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 96/296 (32%), Positives = 136/296 (45%), Gaps = 29/296 (9%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 L DGAM T L+ G + + +L +PE +R +H Y RAG T ++ A Sbjct: 12 LFFDGAMGTMLQEAGLQPGELPETWNLL--HPEKVRAIHQAYVRAGVDILKTNTFGANGL 69 Query: 77 GF-AARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 F AA G E + L+ VE AR A A + + VA +GP G L + Sbjct: 70 KFGAAHGQPEVEE--LVRAGVENARAAFAAEVRDG------FVALDLGPTGKLL----QP 117 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWF-- 193 GD + EA A + +V+A AGADL+ ET+ + EA A +L A A Sbjct: 118 FGDLPFA-EAV-ALYAAQVKAGAAAGADLILIETMSD--SYEAKAAILAAKENADLPIVC 173 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAAL--QHLHGLTVLPLV 251 +FT + L +G + + ++A V A+G NC +T L Q L + + PLV Sbjct: 174 TFTFDEDGKLLNGADVTTAL-VMAESLGVSAVGFNCGQGPDTLVKLVPQALQAVDI-PLV 231 Query: 252 VYPNSGEHYDAVSKT-WHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 PN+G KT +H GE A L + + AG ++GGCC TTP IA L Sbjct: 232 ANPNAGLPVQKDGKTVFHIDGEGYAPL---MVPFAEAGVSVLGGCCGTTPDHIARL 284 >UniRef50_C6JIG3 Methionine synthase n=3 Tax=Fusobacterium RepID=C6JIG3_FUSVA Length = 1112 Score = 70.5 bits (171), Expect = 7e-11, Method: Composition-based stats. Identities = 75/319 (23%), Positives = 135/319 (42%), Gaps = 47/319 (14%) Query: 13 KQDILLLDGAMATELEA-----------RGCNLADSLWSAKVL-VENPELIREVHLDYYR 60 K+ IL+LDGA T ++ +GCN ++L + P++I+E+H Y + Sbjct: 6 KKRILVLDGATGTAIQKYNLSEIDFQGKKGCN--------EILNISRPDIIKEIHTGYIK 57 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGA T S+ G+ E S L K ELAR+ + + + + + VAG Sbjct: 58 AGADIIETNSFNCNRISLKDYGI-EDMSYTLSKKGAELAREIADNFYKTSGK--KIYVAG 114 Query: 121 SVGPYGAYLA----DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEI 176 S+GP L+ D R + + + + ++E ++D GAD + ET+ F + Sbjct: 115 SIGPTSKSLSLPVGDNPYER---ELNFDQMKNIYSEQIEGVIDGGADCILIETI--FDGL 169 Query: 177 EALAELLTAYP-------RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC 229 A A L+ A + S T+ + G + ++ L P +++ G+NC Sbjct: 170 NAKAALIAAEELFEKKNIQLPIMISATVNKQGKIFSGQSIESLIVAL-DRPSIISFGLNC 228 Query: 230 -IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW-QAA 287 ++ ++ + T + +YPN+G + + E YL + Sbjct: 229 SFGAKDLIPMIKKIAAFTDKYISLYPNAG-----LPNENGEYEETPEITTGYLKELVDKK 283 Query: 288 GARLIGGCCRTTPADIAAL 306 ++GGCC T + I A+ Sbjct: 284 QVNILGGCCGTHFSHIKAI 302 >UniRef50_C0EVI7 Methylenetetrahydrofolate reductase n=1 Tax=Eubacterium hallii DSM 3353 RepID=C0EVI7_9FIRM Length = 638 Score = 70.5 bits (171), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 74/308 (24%), Positives = 127/308 (41%), Gaps = 41/308 (13%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 LL DGAM T ++ + + S + + NP L+RE+H Y + GAQ + ++ A Sbjct: 14 LLTDGAMGTYFDS--IEKENYICSEEANITNPALVREIHRSYVKNGAQLLRSNTFLANEG 71 Query: 77 GF------AARGLDEAQSKALIGKSVELARK-AREAYLAENPQAGTLLVAGSVGPYGAYL 129 F A + K LI +LA++ A+E Y E P + A +GP Sbjct: 72 TFLSLTQAKAEAFENITLKQLIIAGYQLAKETAQEVYQEEYP----IFAAADIGPI---- 123 Query: 130 ADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL-TAYPR 188 E R + Q ++ ++ L+AGAD+ ET P+ + +AE + + P Sbjct: 124 ---LEERDSEEADI--LQQYYEI-CDSFLEAGADIFVLETFPDTQYVLKMAEYIRKSCPE 177 Query: 189 ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIA----LENTTAALQHLHG 244 A F+L + + G + ++ + G+NC ++ + G Sbjct: 178 AFIIGQFSLTPTGYSRTGFHYKTILQEATQSGLLDGAGLNCGVGAAHMKKFLKSYIEEFG 237 Query: 245 ------LTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRT 298 LT LP YP + S + + GE ++++ G +++GGCC T Sbjct: 238 VPEDMVLTSLPNCGYPQIVRGHAVYSDSVPYFGEKLGEISEL-------GVQVLGGCCGT 290 Query: 299 TPADIAAL 306 TP I + Sbjct: 291 TPEYIGEI 298 >UniRef50_C0QRY9 Methionine synthase n=3 Tax=Bacteria RepID=C0QRY9_PERMH Length = 1182 Score = 69.7 bits (169), Expect = 1e-10, Method: Composition-based stats. Identities = 80/320 (25%), Positives = 143/320 (44%), Gaps = 44/320 (13%) Query: 7 LRALLDKQDILLLDGAMATELEA-----------RGCNLADSLWSAKVL-VENPELIREV 54 +R L+ K+ +L++DGAM T +++ GCN ++L V P++IR + Sbjct: 4 IRDLIGKK-VLVIDGAMGTMIQSMIIPMEAWEGKTGCN--------EILNVTAPDVIRSI 54 Query: 55 HLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAY-LAENPQA 113 H Y AGA T ++ A P G+ + ++ L EL R+ + Y E P+ Sbjct: 55 HEKYALAGADLIKTNTFGALPWVLEEYGISD-RAYELSKAGAELVRQVCDKYSTPEKPR- 112 Query: 114 GTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNF 173 VAGS+GP G++ H + +R + L+D G D+ ET + Sbjct: 113 ---FVAGSLGP-------GTKLPSLGHIDYDEMYEGYRISAKGLIDGGVDIFLLETFQDP 162 Query: 174 SEIEALAELL--TAYPRAR---AWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGIN 228 +I+A + TA + S T+ + + GT ++ + ++ + ++ LG N Sbjct: 163 LQIKAALHAVQDTAEEYGKDIPVMVSATIELTGTMLIGTDVQTLAVIMEPF-DILTLGFN 221 Query: 229 C-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW-QA 286 C + + L+ L + + ++ N+G + T++ G + AD ++ Sbjct: 222 CGTGPDQIESHLKKLSQVWDGYISIHSNAGLPENRGGHTYYPMGAE--EFADKESRFLDF 279 Query: 287 AGARLIGGCCRTTPADIAAL 306 G ++GGCC TTPA I AL Sbjct: 280 DGVAVVGGCCGTTPAHIKAL 299 >UniRef50_C3WBE7 Methionine synthase n=1 Tax=Fusobacterium mortiferum ATCC 9817 RepID=C3WBE7_FUSMR Length = 1084 Score = 69.7 bits (169), Expect = 1e-10, Method: Composition-based stats. Identities = 73/311 (23%), Positives = 131/311 (42%), Gaps = 35/311 (11%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSA---KVL-VENPELIREVHLDYYRAGAQCAIT 68 ++ IL+LDGAM T ++ N D L ++L + P++I+++HL Y AGA T Sbjct: 11 QKRILVLDGAMGTAIQKYNLNSDDYLGKKGCNEILNITRPDIIKDIHLKYIEAGADIIET 70 Query: 69 ASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 S+ G E ++ + +S ELA++ + +AGS+GP Sbjct: 71 NSFNCNKISLNEYGFSE-RAYEIAKRSAELAKE------VTTTSEKKIYIAGSIGPTNKT 123 Query: 129 LADGS-EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYP 187 L S + D + + + ++E L+D G D+L ET+ F + A +++A Sbjct: 124 LTIPSGKNPYDRDLEFDYLKEAYSEQIEGLIDGGVDILLIETI--FDGLNAKCAVISAEE 181 Query: 188 RAR-------AWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAAL 239 + S T+ + G + ++ L +++ G NC + Sbjct: 182 VMKRKNINLPIMISATVNKEGKIFTGQSIESLIVAL-DRESIISYGFNCSFGAKELIPLT 240 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQ---LADYLPQW-QAAGARLIGGC 295 + L T P+ +YPN+G + GE+ A+YL + ++GGC Sbjct: 241 KKLGKFTKKPISLYPNAG--------LPNEDGEYLESPDITANYLKELVDNQEVNILGGC 292 Query: 296 CRTTPADIAAL 306 C TT I ++ Sbjct: 293 CGTTFEHIKSI 303 >UniRef50_C4GEB2 Putative uncharacterized protein n=1 Tax=Shuttleworthia satelles DSM 14600 RepID=C4GEB2_9FIRM Length = 841 Score = 69.7 bits (169), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 82/299 (27%), Positives = 125/299 (41%), Gaps = 30/299 (10%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLV-ENPELIREVHLDYYRAGAQCAITASYQAT 74 I++LDG M T L+A G +V ++PE++ ++H Y AG+ ++ A Sbjct: 5 IIVLDGGMGTMLQAAGMPAG---QHPEVFGHQHPEIVEQIHRQYIEAGSNVIYANTFGAN 61 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 +D GK+V A + + + + T+ VA +GP G L E Sbjct: 62 ARKLQGCSID-------TGKAVFSAIRTAKRAAQKAAKE-TVRVALDLGPVGELL----E 109 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 G S E +R V A +AGADL+ ET + +I+AL W + Sbjct: 110 PLG--TLSFEEAYEIYREAVVAGYEAGADLIVAETFTDLLDIKALVLAAKENTPLPVWTT 167 Query: 195 FTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLVVY 253 T S GT + + L G V A+GINC + ++ L T LP++ Sbjct: 168 MTFERSGRTFTGTTIASMALTLTGL-GVDAIGINCSLGPTEILPLIEELREWTHLPVIAK 226 Query: 254 PNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQA---AGARLIGGCCRTTPADIAALKAR 309 PN+G D + + E D+ Q QA G ++GGCC T P I L +R Sbjct: 227 PNAG-LPDPRTGVYDLTAE------DFGKQMQAYAELGVSVLGGCCGTDPDYIRCLVSR 278 >UniRef50_B9DIA5 Methylenetetrahydrofolate reductase n=10 Tax=Staphylococcus RepID=B9DIA5_STACT Length = 613 Score = 69.7 bits (169), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 76/307 (24%), Positives = 128/307 (41%), Gaps = 48/307 (15%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K+++L+ DGA+ T L + G + ++ + +P+ I ++H Y +AGA T +Y Sbjct: 9 KENVLVADGAIGTILYSEGIDTCPEAYN----ITHPKKIEQIHRSYIQAGADVIQTNTYG 64 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY-GAYLAD 131 A GL E Q K + +V +A+KA + G+VG + G + Sbjct: 65 ANFEKLQTFGL-EHQVKDITRAAVRIAKKAANE---------DTFILGTVGGFKGVKQNE 114 Query: 132 GSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARA 191 S YH ++ ++ L+D G D L ET + +E+ + Sbjct: 115 LSLSTILYHTDIQ---------IDTLIDEGVDALLFETYYDLNELLQVIRATKKKYDIPV 165 Query: 192 WFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALE------NTTAALQHL--- 242 T ++ +L DGT + + + QV A G + I L + + H+ Sbjct: 166 IAQLTASNTNYLQDGTEINEALK------QVEAEGADVIGLNCHHGPHHMQQSFTHIELP 219 Query: 243 -HGLTVLPLVVYPN-SGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 H L L YPN S ++ S + + + ++A L + G LIGGCC TTP Sbjct: 220 QHAL----LSCYPNASLLDFENSSIKYSDNASYFGKIAKSLVK---EGVHLIGGCCGTTP 272 Query: 301 ADIAALK 307 I +K Sbjct: 273 EHIHYIK 279 >UniRef50_A6QBA6 5-methyltetrahydrofolate--homocysteine methyltransferase n=6 Tax=Bacteria RepID=A6QBA6_SULNB Length = 1169 Score = 69.3 bits (168), Expect = 1e-10, Method: Composition-based stats. Identities = 83/336 (24%), Positives = 136/336 (40%), Gaps = 57/336 (16%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATEL----------------EARGCN--LADSLWSAK 42 MS +++LL+K+ IL++DGAM T++ E GCN L D+ Sbjct: 1 MSITETIKSLLEKR-ILVIDGAMGTQIQDLDVPKEAWIDHSGKEQEGCNELLNDTA---- 55 Query: 43 VLVENPELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKA 102 +LI+ +H Y AGA T ++ P + E ++ L K EL ++ Sbjct: 56 -----ADLIKRIHKRYAMAGADLIKTNTFGTMPWVLDEYQMGE-RAYELSKKGAELVKEI 109 Query: 103 REAYLAENPQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGA 162 Y + + V GS+GP G++ H + ++ L+D G Sbjct: 110 CAEY---STKISPKFVLGSIGP-------GTKLPSLGHIHYDEMYEGYKTVALGLIDGGC 159 Query: 163 DLLACETLPNFSEIEALAELLTAYPRARA-----WFSFTLRDSEHLSDGTPLRDVVALLA 217 D+ ET + +I+A + R S T+ S + GT +V ++ Sbjct: 160 DVFLLETCQDPLQIKAALHACQDANKERGVELPVMVSVTIELSGSMLIGTDATTIVTIME 219 Query: 218 GYPQVVALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQ 276 + +++LG NC + L+ L L +P+ V+ N+G + T++ G Sbjct: 220 PF-DILSLGFNCGTGPDQVKKHLKTLSELCSIPISVHANAGLPQNRGGYTYYPMG----- 273 Query: 277 LADYLPQWQAA-----GARLIGGCCRTTPADIAALK 307 D Q Q G +GGCC TTP I ALK Sbjct: 274 -PDEFTQKQLEFTEFDGVSFLGGCCGTTPQHIQALK 308 >UniRef50_B6YR37 Cobalamin-dependent methionine synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YR37_AZOPC Length = 1224 Score = 69.3 bits (168), Expect = 2e-10, Method: Composition-based stats. Identities = 79/327 (24%), Positives = 143/327 (43%), Gaps = 36/327 (11%) Query: 5 NPLRALLDKQDILLLDGAMAT--------ELEARGCNLA----DSLWSAKVL-VENPELI 51 N + LL ++ ILLLDG M + E + RG A + ++ +L + P++I Sbjct: 2 NSISQLL-QERILLLDGGMGSMIQNYRLKETDYRGLQFAHLSGEMYGNSDILCITRPDII 60 Query: 52 REVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENP 111 + +H Y AGA T S T A G+ E+ ++L + +A++ + Y P Sbjct: 61 QSIHEAYLEAGADIIETNSMNMTAISMADYGI-ESHVESLNKAAATIAKEVAQKYTKLTP 119 Query: 112 QAGTLLVAGSVGPYG--AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACET 169 VAGS+GP + L+ G + + + ++ AL+ G D+L ET Sbjct: 120 DK-PRFVAGSIGPTNKTSSLSPDVNNPGYRNITFTELYKAYCEQIAALIFGGVDILLVET 178 Query: 170 LPNFSEIEALAELLTAYPRARA-------WFSFTLR-DSEHLSDGTPLRDVVALLAGYPQ 221 F + A L+ A + S+TL +S + G L V+ ++ + Sbjct: 179 A--FDTLNVKAALMAAEDEMKIAKKELPLMLSYTLSGNSGRILSGQTLEAVLESIS-HIN 235 Query: 222 VVALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADY 280 ++++G+NC L+ L + + YPN+G + + + E +A+ Sbjct: 236 LLSIGLNCSFGARTMKPFLKKLGQIAPCYVSAYPNAG-----LPNAFGKYNETPEMMAEQ 290 Query: 281 LPQW-QAAGARLIGGCCRTTPADIAAL 306 + ++ + ++GGCC TTP IAA+ Sbjct: 291 IREYIDESLVNIVGGCCGTTPQHIAAI 317 >UniRef50_B3QGP3 Methionine synthase n=71 Tax=cellular organisms RepID=B3QGP3_RHOPT Length = 1293 Score = 68.6 bits (166), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 82/324 (25%), Positives = 136/324 (41%), Gaps = 48/324 (14%) Query: 14 QDILLLDGAMATELEA--------RGCNLADSLWSAK-----VLVENPELIREVHLDYYR 60 Q IL+LDGAM T ++ RG D + +++ P+ I ++H Y R Sbjct: 18 QRILVLDGAMGTMIQQLQLDEAAFRGERFKDFHRDLRGNNDLLILTQPQAIEDIHAQYLR 77 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGT-LLVA 119 AGA T ++ +T A D S+ S + AR AR A + G VA Sbjct: 78 AGADIVATNTFSSTSIAQA----DYDMSELAYEMSRDGARLARNAAAKVEAEDGKPRFVA 133 Query: 120 GSVGPYG--AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE 177 G++GP A ++ G + + + + ++ LLD GAD+L ET+ F + Sbjct: 134 GAIGPTNRTASISPDVANPGYRAVTFDDLRIAYSEQINGLLDGGADILLLETI--FDTLN 191 Query: 178 ALAEL--LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAG-----------YPQVVA 224 A A L + AR D + GT LL+G + + + Sbjct: 192 AKAALYAIAEITEARGI------DVPVMISGTITDKSGRLLSGQMPEAFWNSVRHARPIT 245 Query: 225 LGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQ 283 +G NC + ++ A + + + + YPN+G + + + E +A + + Sbjct: 246 IGFNCALGAKDLRAHIADISRVADTLVCAYPNAG-----LPNEFGQYDESPEYMASLVGE 300 Query: 284 WQAAG-ARLIGGCCRTTPADIAAL 306 + AG ++GGCC TTPA I A+ Sbjct: 301 FAEAGLVNIVGGCCGTTPAHIKAI 324 >UniRef50_C3MDS4 Homocysteine S-methyltransferase, putative n=12 Tax=Bacteria RepID=C3MDS4_RHISN Length = 352 Score = 68.6 bits (166), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 90/315 (28%), Positives = 137/315 (43%), Gaps = 39/315 (12%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLADS--LWSAKVLVENPELIREVHLDYYRAG 62 N L LL ++ +LL DGA T L A G ++ LW+ PE I ++H D+ AG Sbjct: 20 NALSDLLAQKGVLLADGATGTSLFAMGLEAGEAPELWNET----KPENITKLHQDFVDAG 75 Query: 63 AQCAITASYQATPAGFAARGLDEAQSK--ALIGKSVELARKAREAYLAENPQAGTLLVAG 120 A +T S+ T L +A+ + AL ++ E+AR A + P+ ++ AG Sbjct: 76 ADIILTNSFGGTRHRLK---LHQAEDRVHALNKRAAEIAR----AVADKAPR--KVITAG 126 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 SVGP G L Y +V AF ++E L GA++ ET+ + EI A A Sbjct: 127 SVGPTGELLIPLGAL--SYEDAVSAFAE----QIEGLKAGGAEVAWIETMSSPDEIRAAA 180 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGT-------PLRDVVALLAGYPQVVALGINC-IAL 232 E T + F S + T L V A + P VA+G NC + Sbjct: 181 EAAT-----KVGLPFVYTGSFDTAGKTMMGLHPKDLHTVAAEIGEGP--VAVGANCGVGA 233 Query: 233 ENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLI 292 + ++L + VV + + H+ G +A+Y AGAR+I Sbjct: 234 SDILSSLLDMTAANPEGTVVVKGNCGIPEFRGSEIHYSGTP-PLMAEYARLAVDAGARII 292 Query: 293 GGCCRTTPADIAALK 307 GGCC T+ +AA++ Sbjct: 293 GGCCGTSCNHLAAMR 307 >UniRef50_Q99707 Methionine synthase n=289 Tax=cellular organisms RepID=METH_HUMAN Length = 1265 Score = 68.2 bits (165), Expect = 4e-10, Method: Composition-based stats. Identities = 85/326 (26%), Positives = 144/326 (44%), Gaps = 41/326 (12%) Query: 5 NPLRALLDKQDILLLDGAMATELEA--------RGCNLADSLWSAK-----VLVENPELI 51 + + A+L K+ I++LDG M T ++ RG D K + + P++I Sbjct: 20 DEINAILQKR-IMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVI 78 Query: 52 REVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENP 111 ++H +Y AGA T ++ +T A GL+ + + S +ARKA E Sbjct: 79 YQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMC-SAGVARKAAEEVTL--- 134 Query: 112 QAG-TLLVAGSVGPYGAYLA-DGSEYRGDY-HCSVEAFQAFHRPRVEALLDAGADLLACE 168 Q G VAG++GP L+ S R DY + + + ++ + + LLD G D+L E Sbjct: 135 QTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIE 194 Query: 169 TLPNFSEIEALAELLT-------AYPRARAWFSFTLRDS--EHLSDGTPLRDVVALLAGY 219 T+ F A A L Y + S T+ D LS T V+++ G Sbjct: 195 TI--FDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGE 252 Query: 220 PQVVALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLA 278 P + +G+NC + ++ + T ++ YPN+G + T+ + E + +A Sbjct: 253 P--LCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAG-----LPNTFGDYDETPSMMA 305 Query: 279 DYLPQWQAAG-ARLIGGCCRTTPADI 303 +L + G ++GGCC +TP I Sbjct: 306 KHLKDFAMDGLVNIVGGCCGSTPDHI 331 >UniRef50_B4DST3 cDNA FLJ56487, highly similar to Methionine synthase (EC 2.1.1.13) n=1 Tax=Homo sapiens RepID=B4DST3_HUMAN Length = 1118 Score = 67.8 bits (164), Expect = 4e-10, Method: Composition-based stats. Identities = 85/326 (26%), Positives = 144/326 (44%), Gaps = 41/326 (12%) Query: 5 NPLRALLDKQDILLLDGAMATELEA--------RGCNLADSLWSAK-----VLVENPELI 51 + + A+L K+ I++LDG M T ++ RG D K + + P++I Sbjct: 20 DEINAILQKR-IMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVI 78 Query: 52 REVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENP 111 ++H +Y AGA T ++ +T A GL+ + + S +ARKA E Sbjct: 79 YQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMC-SAGVARKAAEEVTL--- 134 Query: 112 QAG-TLLVAGSVGPYGAYLA-DGSEYRGDY-HCSVEAFQAFHRPRVEALLDAGADLLACE 168 Q G VAG++GP L+ S R DY + + + ++ + + LLD G D+L E Sbjct: 135 QTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIE 194 Query: 169 TLPNFSEIEALAELLT-------AYPRARAWFSFTLRDS--EHLSDGTPLRDVVALLAGY 219 T+ F A A L Y + S T+ D LS T V+++ G Sbjct: 195 TI--FDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGE 252 Query: 220 PQVVALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLA 278 P + +G+NC + ++ + T ++ YPN+G + T+ + E + +A Sbjct: 253 P--LCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAG-----LPNTFGDYDETPSMMA 305 Query: 279 DYLPQWQAAG-ARLIGGCCRTTPADI 303 +L + G ++GGCC +TP I Sbjct: 306 KHLKDFAMDGLVNIVGGCCGSTPDHI 331 >UniRef50_B7ZLW7 MTR protein n=1 Tax=Homo sapiens RepID=B7ZLW7_HUMAN Length = 1214 Score = 67.8 bits (164), Expect = 4e-10, Method: Composition-based stats. Identities = 85/326 (26%), Positives = 144/326 (44%), Gaps = 41/326 (12%) Query: 5 NPLRALLDKQDILLLDGAMATELEA--------RGCNLADSLWSAK-----VLVENPELI 51 + + A+L K+ I++LDG M T ++ RG D K + + P++I Sbjct: 20 DEINAILQKR-IMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVI 78 Query: 52 REVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENP 111 ++H +Y AGA T ++ +T A GL+ + + S +ARKA E Sbjct: 79 YQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMC-SAGVARKAAEEVTL--- 134 Query: 112 QAG-TLLVAGSVGPYGAYLA-DGSEYRGDY-HCSVEAFQAFHRPRVEALLDAGADLLACE 168 Q G VAG++GP L+ S R DY + + + ++ + + LLD G D+L E Sbjct: 135 QTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIE 194 Query: 169 TLPNFSEIEALAELLT-------AYPRARAWFSFTLRDS--EHLSDGTPLRDVVALLAGY 219 T+ F A A L Y + S T+ D LS T V+++ G Sbjct: 195 TI--FDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGE 252 Query: 220 PQVVALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLA 278 P + +G+NC + ++ + T ++ YPN+G + T+ + E + +A Sbjct: 253 P--LCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAG-----LPNTFGDYDETPSMMA 305 Query: 279 DYLPQWQAAG-ARLIGGCCRTTPADI 303 +L + G ++GGCC +TP I Sbjct: 306 KHLKDFAMDGLVNIVGGCCGSTPDHI 331 >UniRef50_Q8DUN2 Methylenetetrahydrofolate reductase n=12 Tax=Streptococcus RepID=Q8DUN2_STRMU Length = 618 Score = 67.8 bits (164), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 86/313 (27%), Positives = 124/313 (39%), Gaps = 47/313 (15%) Query: 10 LLDK--QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAI 67 LLDK DIL+ DGAM T L A G ++ + +PE I +H Y AGA Sbjct: 4 LLDKLKTDILVADGAMGTLLYADGLESCHEYYN----ISHPERILAIHQAYIAAGADIIQ 59 Query: 68 TASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGA 127 T +Y A + G D+ + KA+ +V LAR+A V G++G Sbjct: 60 TNTYGAKRHRLKSFGHDK-EVKAINQAAVHLARQA---------AGDNTFVLGTIGAS-- 107 Query: 128 YLADGSEYRGDYHC--SVEAFQAFHRPRVEALLDAG-ADLLACETLPNFSEIEALAELLT 184 G HC S+E + + LL+ D L ET + E+EA + L Sbjct: 108 --------HGLKHCELSLEDIISQTVEQARFLLETKQIDGLLLETYYDIEELEAALKALR 159 Query: 185 AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHG 244 + L + +G PL + + +V LG + + L + Sbjct: 160 PLTDLPIITNVALHEPGITENGRPL------VEAFSNLVMLGADIVGLNCHLGPYHMIQS 213 Query: 245 LTVLPLVV------YPNSGEHYDAVSKTWHHHGEHCAQLADYLPQ----WQAAGARLIGG 294 +PL YPN+ + S + H +Q ADY + G RLIGG Sbjct: 214 FKQVPLFAQSYLSAYPNAS--LLSFSSDDNETPYHFSQNADYFEYCAKLFVEEGVRLIGG 271 Query: 295 CCRTTPADIAALK 307 CC TTP I A+K Sbjct: 272 CCGTTPEHIKAIK 284 >UniRef50_A7VPD0 Methylenetetrahydrofolate reductase n=1 Tax=Clostridium leptum DSM 753 RepID=A7VPD0_9CLOT Length = 600 Score = 67.4 bits (163), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 76/320 (23%), Positives = 128/320 (40%), Gaps = 60/320 (18%) Query: 7 LRALLDKQDILLLDGAMATELEAR-GCNLADSLWSAKVLVENPELIREVHLDYYRAGAQC 65 L LL ++ ++ DGAM T + G ++ + W+ + PELI E+H +Y +AGAQ Sbjct: 3 LDTLLKQKRPVITDGAMGTYFTQKTGFSIHECEWAN---ISRPELISEIHREYVKAGAQF 59 Query: 66 AITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY 125 T ++ A G A ++ LA++A + G Sbjct: 60 LRTNTFSANTKSL---GRPLADVLEIVRAGYRLAKEAAGCQAVAAADMTAIYPRGD---- 112 Query: 126 GAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL-T 184 + ++ +Y +AF L GA++ ETL S + +A+ L Sbjct: 113 -----EETDLLPEYLAIADAF-----------LSEGAEVFLFETLTELSPFDQIADYLKK 156 Query: 185 AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVV-ALGINC---------IALEN 234 P + SFT+ G PLR ++ + + ++ +G+NC A E Sbjct: 157 KKPECKVLISFTVSPEGITRLGVPLRRLLDEVKPHRELFDGIGLNCGCGPAHILKFAREL 216 Query: 235 TTAALQHLHGLTVLPLVVYPNSG--------EHYDAVSKTWHHHGEHCAQLADYLPQWQA 286 + + Q+L LP++V PN+G +D + + H A+L Sbjct: 217 LSYSRQYLS----LPVLVMPNAGYPAMEENRTVFDTSPEYFSHQAVRIAEL--------- 263 Query: 287 AGARLIGGCCRTTPADIAAL 306 G +IGGCC TTP + L Sbjct: 264 -GVDMIGGCCGTTPKHLQLL 282 >UniRef50_Q7M929 S-METHYLTRANSFERASE n=1 Tax=Wolinella succinogenes RepID=Q7M929_WOLSU Length = 1120 Score = 67.4 bits (163), Expect = 6e-10, Method: Composition-based stats. Identities = 81/312 (25%), Positives = 142/312 (45%), Gaps = 35/312 (11%) Query: 11 LDKQDILLLDGAMATELEARGCNLADSLWSAK------VLVENPELIREVHLDYYRAGAQ 64 + +Q +++LDGAM TE++ +L + W K + V ++I +H Y AGA Sbjct: 9 IHRQRVMILDGAMGTEIQK--FDLKEEDWEEKAGCSEILNVTRGDVILSIHRSYLEAGAD 66 Query: 65 CAITASYQATPAGFAARGLD-EAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVG 123 + ++ A P G+ A A G ++A++A +++ A +P+ VAGS+G Sbjct: 67 ILKSNTFGALPWVLEEYGIGGRAYEMAFAG--AQIAKEACDSF-APSPR----FVAGSLG 119 Query: 124 PYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA--- 180 P G L DY E ++ R L + GADL ET + +I+A Sbjct: 120 P-GTKLPSLGHI--DYDTMFEGYKEAAR----GLKEGGADLFLLETCQDPLQIKAAVHAC 172 Query: 181 -ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAA 238 E+ ++ P S T+ + + GT ++ + +L ++ +LGINC + + Sbjct: 173 KEVDSSMP---IMVSATIETTGTMLIGTDIKTLAVILEPL-EIFSLGINCGLGPDMAEKH 228 Query: 239 LQHLHGLTVLPLVVYPNSGEHYDAVSKTWH-HHGEHCAQLADYLPQWQAAGARLIGGCCR 297 L+ L PL ++ N+G + T++ + A++ + + G +GGCC Sbjct: 229 LKALAQYAPFPLSIHANAGLPQNVGGCTFYPMEPKEFAEIEEEFLGIE--GVAFLGGCCG 286 Query: 298 TTPADIAALKAR 309 TTP I LK R Sbjct: 287 TTPEHIRQLKER 298 >UniRef50_UPI0001C311AB homocysteine S-methyltransferase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C311AB Length = 1189 Score = 67.4 bits (163), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 84/325 (25%), Positives = 135/325 (41%), Gaps = 49/325 (15%) Query: 7 LRALLD--KQDILLLDGAMATELEARGCNLAD-----SLWSAKVLVENPELIREVHLDYY 59 +R LD + +++ DG M LE D +++ P++I VH Sbjct: 1 MRDYLDAIRSRVVVFDGGMGATLEQFELTEKDYGGLQGKCHEALILHRPDVIEGVHTTML 60 Query: 60 RAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVA 119 AGA T ++QA+ GL E + + + E+ARKA + VA Sbjct: 61 DAGADVVETDTFQASRLKLEEWGLGE-HTLEINRRGAEIARKAAGEHR---------YVA 110 Query: 120 GSVGPYGAYLADGSEYRGD--YHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE 177 GS+GP G A G+ + VE F + + L++ GADLL ET + E++ Sbjct: 111 GSIGPTGFLPASDDPTLGNISFRALVEVFAE----QAQGLIEGGADLLMIETAQDILEVK 166 Query: 178 ALAELLTAYPRARAWFSFTLR------------DSEHLSDGTPLRDVVALLAGYPQVVAL 225 A + AR F T R + + GT + V+ L V AL Sbjct: 167 A------SVFGAREAFKTTGRKIPIQVSVSLLPNGGKMLLGTDISAVLTTLTAL-DVDAL 219 Query: 226 GINC-IALENTTAALQHLHGLTVLPLVVYPNSG---EHYDAVSKTWHHHGEHCAQLADYL 281 G+NC E+ A++ L + +P+ PN+G + D + A L +++ Sbjct: 220 GLNCSTGPEDMRDAIRFLGEFSPVPVHCIPNAGLPLQGPDGETIFPEKPEPLAASLTEFV 279 Query: 282 PQWQAAGARLIGGCCRTTPADIAAL 306 ++ G ++GGCC TT A I A+ Sbjct: 280 ERY---GVSIVGGCCGTTAAHIRAI 301 >UniRef50_B8I366 Homocysteine S-methyltransferase n=1 Tax=Clostridium cellulolyticum H10 RepID=B8I366_CLOCE Length = 434 Score = 67.0 bits (162), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 74/302 (24%), Positives = 127/302 (42%), Gaps = 37/302 (12%) Query: 13 KQDILLLDGAMATELEARGCNLAD--SLWSAKVLVENPELIREVHLDYYRAGAQCAITAS 70 ++ +L+ DG+M L+++G + W+ + +PE+++E++ Y AGA + + Sbjct: 8 EKKVLVFDGSMGIMLQSKGLEVGTCPEEWN----ITHPEMVKEIYTAYRDAGANVIQSNT 63 Query: 71 YQATPAGFAARGL-DEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYL 129 +Q+ + GL D+ G S+ + Y VA S+GP G L Sbjct: 64 FQSNLMKLSEYGLQDKHYDINFAGVSLAKEVMGDKGY-----------VAASIGPLGKLL 112 Query: 130 ADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE--IEALAELLTAYP 187 E + +A+ F + +V A+ GAD+++ ET + SE I LA Sbjct: 113 EPFGELTFE-----QAYNTF-KEQVVAVTAGGADIISFETFTDVSEMRIALLASKENCNL 166 Query: 188 RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTV 247 S+ ++ L P V A + +G NC + +G T Sbjct: 167 PVICSISYE-QNGRTLMGSDPA--VCACILHSLGADMIGTNCSFGPEYMIKVAESYGKTG 223 Query: 248 LPLVVYPNSGEHYDAVSKTWHH---HGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 L + PN+G + KT + E + A+Y ++ GARL+GGCC T P IA Sbjct: 224 LKFSIKPNAG-----IPKTVDGNLVYDETPEKFAEYAQEFIKYGARLVGGCCGTRPEFIA 278 Query: 305 AL 306 + Sbjct: 279 EI 280 >UniRef50_A5UPF4 Methionine synthase (B12-dependent) n=5 Tax=Chloroflexaceae RepID=A5UPF4_ROSS1 Length = 1254 Score = 67.0 bits (162), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 81/313 (25%), Positives = 147/313 (46%), Gaps = 30/313 (9%) Query: 13 KQDILLLDGAMATELEARGCNLAD----SLWSAK--VLVENPELIREVHLDYYRAGAQCA 66 ++ +L+ DGAM T ++ AD + + A+ +++ P++I ++H + AGA Sbjct: 55 RERVLIYDGAMGTSIDTFHLTAADYGGENTFGARDYLVMTRPDVIEQIHTSFLEAGADVL 114 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 T ++Q+T GL + Q+ A+ + LAR+ +A+ A + + VAGS+GP G Sbjct: 115 ETCTFQSTRIRLEEWGLAD-QTHAINVAAARLARRVADAFEARDGRP--RYVAGSMGPTG 171 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 + D + + + AL++ G D+L ET + E++A L Sbjct: 172 KLPSSDDPSLSD--ITFDQLSDIFYEQAVALIEGGVDVLLVETSVDILEVKA---ALDGI 226 Query: 187 PRARAWFS---------FTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTT 236 RA+A + L S + GT + +VA L P V +G+NC E+ Sbjct: 227 RRAKADLNRPDVAVQAQVFLDLSGKMLLGTEVPALVATLEAMP-VDVIGLNCSTGPEHMR 285 Query: 237 AALQHLHGLTVLPLVVYPNSGEHYDAVSKT-WHHHGEHCAQ-LADYLPQWQAAGARLIGG 294 A++++ + P+ PN+G + +T + E A+ L +Y+ ++ G ++GG Sbjct: 286 EAIRYMTRHSRKPISCIPNAGLPIEVNGETVYPMEPEPFARILGEYVHEY---GVAVVGG 342 Query: 295 CCRTTPADIAALK 307 CC T PA I L+ Sbjct: 343 CCGTRPAHIRRLR 355 >UniRef50_D0LSQ2 Methylenetetrahydrofolate reductase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LSQ2_HALO1 Length = 643 Score = 66.6 bits (161), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 88/327 (26%), Positives = 141/327 (43%), Gaps = 60/327 (18%) Query: 1 MSQNNPLRALLDK--QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDY 58 MS + L+ L+ Q LL DGAM + L RG + + ++ + P+LIR VH +Y Sbjct: 1 MSGTSCLKPFLEALAQGPLLFDGAMGSLLYDRG--VFHTRNYDELSLSQPKLIRAVHREY 58 Query: 59 YRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKARE--AYLAENPQAGTL 116 AGAQ T ++ A A G E + + +VE+AR + AY Sbjct: 59 LEAGAQILETNTFGANRIKLTAHGHSE-RVADINRAAVEMARSVADDRAY---------- 107 Query: 117 LVAGSVGPYGA--YLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFS 174 VAG+VGP G +A +E + A +A +++ L++AG DLL ET Sbjct: 108 -VAGAVGPTGIRYTIAPAAERK-------RAIEALGE-QIDYLVEAGVDLLCLETFGAIL 158 Query: 175 EIEALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALL--------------AGYP 220 E+EA EL + + D++ L +G VA G P Sbjct: 159 ELEAAIELARQIAPEMPVVAHLVFDADGLVEGELDGATVAQRLIAAGANAVGANCGVGPP 218 Query: 221 QVVALGINCIALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWH-HHGEHCAQLAD 279 ++ A+G + + A P+ + PN+G + +T + + EH A Sbjct: 219 ELYAVGTK---MSDVGA-----------PVSIQPNAGFPSNIDGRTIYVANPEHFGVFAR 264 Query: 280 YLPQWQAAGARLIGGCCRTTPADIAAL 306 + + +G R++GGCC TTP + A+ Sbjct: 265 RMLK---SGVRMVGGCCGTTPEHVRAM 288 >UniRef50_C7LX76 Methylenetetrahydrofolate reductase n=1 Tax=Desulfomicrobium baculatum DSM 4028 RepID=C7LX76_DESBD Length = 599 Score = 66.6 bits (161), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 91/306 (29%), Positives = 132/306 (43%), Gaps = 49/306 (16%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 + +++ DGAM + L RG + + S + A L E P L++ +H Y AGA+ T ++ A Sbjct: 11 ERVVVADGAMGSLLFDRGVD-SSSCYDALNLTE-PALVQSIHKAYADAGAEILETNTFGA 68 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKARE-----AYLAENPQAGTLLVAGSVGPYGAY 128 ++ +G+ +LA RE A LA VAG++GP G Sbjct: 69 --------------NRVKLGR-YDLAHTTREINLRGAELARGEAGAGRWVAGAMGPLGRM 113 Query: 129 LADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA--- 185 D S E + + AL++ G D + ET + S + + A Sbjct: 114 GLDA--------VSQEEMEDVFSQQALALVEGGVDFIMLETFASLSLLLTALRGVKACVS 165 Query: 186 YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHG 244 P A A FT R H S T AL+ VV G+NC I +N +Q L Sbjct: 166 VPVA-AQMVFTQRGRTH-SGHTARECFDALIRAGADVV--GLNCGIGPKNALEVVQGLGP 221 Query: 245 LTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAA----GARLIGGCCRTTP 300 +TV PL V PN+G + + + A +Y + AA GARL+GGCC T P Sbjct: 222 VTV-PLSVLPNAGFPESSGDRLIY------ASSPEYFARRTAACATYGARLLGGCCGTAP 274 Query: 301 ADIAAL 306 IAAL Sbjct: 275 EHIAAL 280 >UniRef50_Q146H9 Methionine synthase (B12-dependent) n=21 Tax=cellular organisms RepID=Q146H9_BURXL Length = 359 Score = 66.2 bits (160), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 94/326 (28%), Positives = 140/326 (42%), Gaps = 38/326 (11%) Query: 7 LRALLDKQDILLLDGAMAT--------ELEARGCNLADSLWSAK-----VLVENPELIRE 53 L ALL K IL+LDGAM T E RG D K + + P++I E Sbjct: 23 LPALL-KSRILILDGAMGTMIQRYKLDEARYRGERFKDYGRDIKGNNELLSITQPQIISE 81 Query: 54 VHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAY-LAENPQ 112 +H Y AGA T ++ AT A G+ EA + + +S +LAR A + Y + P+ Sbjct: 82 IHEQYLAAGADIVETNTFGATTVAQADYGM-EALAVEMNLESAKLARAACDKYSTPDKPR 140 Query: 113 AGTLLVAGSVG--PYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETL 170 VAG++G P A ++ G + + + +A + + ALLD G DL ET+ Sbjct: 141 ----FVAGAIGPTPKTASISPDVNDPGARNVTFDELRAAYYEQARALLDGGVDLFLVETI 196 Query: 171 PNFSEIEALAELLT-------AYPRARAWFSFTLRD-SEHLSDGTPLRDVVALLAGYPQV 222 F + A A L R S T+ D S + G + L + + Sbjct: 197 --FDTLNAKAALFALDELFEDTGERLPIMISGTVTDASGRILSGQTVEAFWNSLR-HAKP 253 Query: 223 VALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYL 281 + G+NC + + L L + YPN+G + +S T E A + L Sbjct: 254 LTFGLNCALGAALMRPYIAELAKLCDTYVSCYPNAGLP-NPMSDTGFD--ELPADTSGLL 310 Query: 282 PQWQAAG-ARLIGGCCRTTPADIAAL 306 ++ AG + GGCC TTP IAA+ Sbjct: 311 KEFAQAGLVNIAGGCCGTTPEHIAAI 336 >UniRef50_C6W4B8 Methionine synthase n=4 Tax=Bacteria RepID=C6W4B8_DYAFD Length = 1274 Score = 66.2 bits (160), Expect = 1e-09, Method: Composition-based stats. Identities = 86/343 (25%), Positives = 140/343 (40%), Gaps = 53/343 (15%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEA--------RGCNLADSLWSAKVLVEN------ 47 +Q +R +L K IL+LDGAM T ++ RG AD W V N Sbjct: 4 TQKADIREIL-KNRILVLDGAMGTMIQRYKLQDHDYRGERFAD--WPHDVKGNNDLLSLT 60 Query: 48 -PELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAY 106 P++I+E+H Y+ AGA A T ++ T A G++E + L +S LAR+ + + Sbjct: 61 RPDIIKEIHAAYFAAGADIAETNTFSGTTIAMADYGMEEIVYE-LNYESARLAREVADEF 119 Query: 107 LAENPQAGTLLVAGSVGPYG--AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADL 164 P VAGS+GP A L+ G S + + +V+ L D G DL Sbjct: 120 TEREPHK-PRFVAGSIGPTNRTASLSPDVNNPGFRAISFDQLVEAYYEQVKGLTDGGCDL 178 Query: 165 LACETLPNFSEIEALAELLTA---YPRARA--------W-----------FSFTLRDSEH 202 L ET+ F + A A L + A+A W S T+ D+ Sbjct: 179 LLVETI--FDTLNAKAALFAIDQFFADAKAGKVEHLESWRIEPGQALPIMISGTITDASG 236 Query: 203 LSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYD 261 + + + ++++G+NC + + +Q + + +PN+G Sbjct: 237 RTLSGQTTEAFLTSVSHLPLLSVGLNCALGADLMRPYVQIMAKESPFYTSAHPNAG---- 292 Query: 262 AVSKTWHHHGEHCAQLADYLPQWQAAG-ARLIGGCCRTTPADI 303 + + E Q+ + + + +IGGCC TTP I Sbjct: 293 -LPNEMGEYDETPEQMGEVIDGFLRDNLVNIIGGCCGTTPDHI 334 >UniRef50_Q55786 Methionine synthase n=14 Tax=Cyanobacteria RepID=METH_SYNY3 Length = 1195 Score = 66.2 bits (160), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 82/306 (26%), Positives = 132/306 (43%), Gaps = 31/306 (10%) Query: 16 ILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREVHLDYYRAGAQCAITA 69 +L+ DGAM T L+ + AD + ++ PE + VH +Y AGA T Sbjct: 16 VLVFDGAMGTNLQVQNLTAADFGGAEYEGCNEYLVHTKPEAVATVHRAFYEAGADVVETD 75 Query: 70 SYQATPAGFAARGLDEAQSKALIGKSVELARKAREAY-LAENPQAGTLLVAGSVGPYGAY 128 ++ TP A L + QS L + ELA+ + E P+ VAGS+GP Sbjct: 76 TFGGTPLVLAEYDLAD-QSYYLNKAAAELAKAVAAEFSTPEKPR----FVAGSMGP---- 126 Query: 129 LADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY-- 186 G++ H ++ + + +V L D G DLL ET + +I+A + Sbjct: 127 ---GTKLPTLGHVDYDSLKDAYVVQVRGLYDGGVDLLLVETCQDVLQIKAALNAIEQVFA 183 Query: 187 ---PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLH 243 R S T+ + GT + +A+L YP + LG+NC + +H+ Sbjct: 184 EKGDRLPLMVSVTMETMGTMLVGTEMAAALAILEPYP-IDILGLNCATGPDLMK--EHVK 240 Query: 244 GLTV-LPLVV--YPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 L+ P VV PN+G + + ++ Q++ + + G ++IGGCC T P Sbjct: 241 YLSEHSPFVVSCIPNAGLPENVGGQAFYRLTPMELQMS-LMHFIEDLGVQVIGGCCGTRP 299 Query: 301 ADIAAL 306 I AL Sbjct: 300 DHIKAL 305 >UniRef50_UPI0001BC43AA B12-dependent methionine synthase n=1 Tax=Fusobacterium ulcerans ATCC 49185 RepID=UPI0001BC43AA Length = 1113 Score = 66.2 bits (160), Expect = 1e-09, Method: Composition-based stats. Identities = 72/310 (23%), Positives = 131/310 (42%), Gaps = 29/310 (9%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAK------VLVENPELIREVHLDYYRAGAQCA 66 K+ +L+LDGA T ++ NL D + K + + P++I+E+H Y AGA Sbjct: 6 KKRVLVLDGATGTAIQKY--NLTDEDFQGKKGCNEILNITRPDVIKEIHTKYIEAGADII 63 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 T S+ + E S L K ELAR+ + + + + + VAGS+GP Sbjct: 64 ETNSFNCNRISLKDYEI-EDMSYTLSKKGAELARETADNFYKTSGK--KIYVAGSIGPTS 120 Query: 127 AYLA-DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA 185 L+ + + + + + + ++E ++D G D L ET+ F + A A L+ A Sbjct: 121 KSLSLPMGDVPYEREINFDQMKKIYSEQIEGVIDGGVDCLLIETI--FDGLSAKAALVAA 178 Query: 186 YP-------RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTA 237 + S T+ + G + ++ L P +++ G+NC + Sbjct: 179 EELFEKKNIQLPIMISATVNRQGKIFSGQSIESLITAL-DRPSIISFGLNCSFGARDLIP 237 Query: 238 ALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW-QAAGARLIGGCC 296 ++ + T + +YPN+G + + E A YL + ++GGCC Sbjct: 238 MIKRIASFTDKYISLYPNAG-----LPNEEGEYEETPEITAGYLKELVDEKKVNILGGCC 292 Query: 297 RTTPADIAAL 306 T + I A+ Sbjct: 293 GTHFSHIKAI 302 >UniRef50_B7AQD9 Methylenetetrahydrofolate reductase n=1 Tax=Bacteroides pectinophilus ATCC 43243 RepID=B7AQD9_9BACE Length = 603 Score = 65.1 bits (157), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 68/294 (23%), Positives = 116/294 (39%), Gaps = 28/294 (9%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 L+ DGAM T N ++ +E P++I +H +Y AGA+ T ++ A Sbjct: 14 LITDGAMGTYYSEITNN--PEAFAEFANIERPDIIERIHNEYIDAGAKLIRTNTFAANTQ 71 Query: 77 GFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYR 136 G+ + K LI + +A++ + G VAG +GP + + +E Sbjct: 72 ML---GIGRDELKKLIEDACRIAQRCAD---------GRAYVAGDIGP----IKENAESE 115 Query: 137 GDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSFT 196 G +VE ++ + LD D + ET +F +I+ +AE + + F Sbjct: 116 GS---AVEEYKMI----CDIFLDMKVDAIRFETFADFDDIKEVAEYVRSKSDMFIMADFC 168 Query: 197 LRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLVVYPN 255 L + + G ++ + + G NC I + +Q L + PN Sbjct: 169 LNKNGFTAGGISAARIMQQAGQMDCIDSCGFNCGIGSGHMNNIMQKLTFAKDKYMSCLPN 228 Query: 256 SGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKAR 309 +G Y + + D + + A G +IGGCC T PA I L R Sbjct: 229 AG--YPEQMNNRMVFMNNASYFCDNMQKISAYGMNIIGGCCGTKPAYIRELCRR 280 >UniRef50_A4WQF1 Homocysteine S-methyltransferase n=39 Tax=Alphaproteobacteria RepID=A4WQF1_RHOS5 Length = 357 Score = 65.1 bits (157), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 97/317 (30%), Positives = 143/317 (45%), Gaps = 45/317 (14%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLAD--SLWSAKVLVENPELIREVHLDYYRAGAQ 64 L +L ++ L+ DGA T L G + + LW+ ++ P+ IR ++ AG+ Sbjct: 27 LSRMLQTREWLMADGATGTNLFNMGLSSGEPPELWN----IDRPDNIRALYRAAVEAGSD 82 Query: 65 CAITASYQATPAGFAAR-GLDEAQSKALIGKSVELARKARE-AYLAENPQAGTLLVAGSV 122 +T S+ G AAR L EAQ G+ EL R A E + T++VAGS+ Sbjct: 83 IFLTNSF----GGNAARLKLHEAQ-----GRVGELNRTAAELGREVADASGRTVVVAGSM 133 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G E G + A + FH + EAL GAD+L ET+ E +A AE Sbjct: 134 GPTGEIF----EPMGTLTHRM-AVEIFHE-QAEALKAGGADVLWVETISAAEEFKAAAEA 187 Query: 183 LTAYPRARAWFSFTLRDS--EHLSDGTP--LRDVVALLAGYPQVVALGINCIALENTTAA 238 W D+ + TP L D+V L P +A G NC + Sbjct: 188 ARLA--GMPWCGTMSFDTAGRTMMGLTPAALVDLVTKLPNPP--LAFGANCGV--GASDL 241 Query: 239 LQHLHGLTV----LPLVVYPNSG--EHYDAVSKTWHHHGEHCAQL-ADYLPQWQAAGARL 291 L+ + G T LP++ N+G +++D H H + L A+Y + AGAR+ Sbjct: 242 LRTVLGFTAQGVELPVIAKGNAGIPKYHDG-----HIHYDGTPDLMAEYAVLARDAGARV 296 Query: 292 IGGCCRTTPADIAALKA 308 IGGCC T P + A++A Sbjct: 297 IGGCCGTMPEHLRAMRA 313 >UniRef50_Q5UEY6 Putative homocysteine S-methyltransferase family protein n=1 Tax=uncultured alpha proteobacterium EBAC2C11 RepID=Q5UEY6_9PROT Length = 309 Score = 64.7 bits (156), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 81/317 (25%), Positives = 129/317 (40%), Gaps = 41/317 (12%) Query: 10 LLDKQDILL---LDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 L+ K++ LL LD ++TELE RG + + WS V +++ E + E H+ Y AGA Sbjct: 8 LIKKREQLLPIILDSGVSTELERRGAKMRNGQWSGCVAIDDYEKLVETHIAYIEAGADII 67 Query: 67 ITASYQATPAGFAARGL-DEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY 125 SY ++ GL DE + + ++ A +ARE + VAGS+ + Sbjct: 68 TVNSYASSRLMLGPAGLGDEVERINRL--NISAAIEAREK------TGANVSVAGSIS-H 118 Query: 126 GAYLADGSE-YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 DG E + S E + + + G DL+ E + S +A L Sbjct: 119 ALPFTDGVEGAKQQPDISPEELSNCYGEMISIFENKGVDLILLEMM---SIPARMAPLFN 175 Query: 185 AYPRAR--AWFSFTLRDSEHLSDGTPLRDV------VALLAGYPQVVALGINCIALENTT 236 ++ W + + L+ T D + + A A+GI +++ Sbjct: 176 CANKSSLPIWCGLSAKRETPLAALTSWHDTSVSFEDIVIQACQYDFDAIGIMHTSVDAIE 235 Query: 237 AAL----QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQ---LADYLPQWQAAGA 289 AAL H G+ L+ YP+SG V+ W E + L +Y WQ +G Sbjct: 236 AALVVIKNHFSGM----LMAYPDSGYF---VAPNWQF--EDIIEPHALVEYAKGWQKSGC 286 Query: 290 RLIGGCCRTTPADIAAL 306 + GGCC P AL Sbjct: 287 SIFGGCCGLGPEHTTAL 303 >UniRef50_C7JFY7 Methionine synthase n=8 Tax=Acetobacter pasteurianus RepID=C7JFY7_ACEP3 Length = 1187 Score = 64.7 bits (156), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 82/325 (25%), Positives = 139/325 (42%), Gaps = 38/325 (11%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVE-----NPELIREVH 55 MS PL L Q +LL DG M + ++ ++ W + E PELIRE+H Sbjct: 20 MSSRLPLLDALRDQ-VLLCDGGMGSRIQMLDLDVQRDYWGQENCTEILTLSRPELIREIH 78 Query: 56 LDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGT 115 Y+ AGA T ++ +P L + +++ + S LAR+A E++ + T Sbjct: 79 RGYFEAGADMVETNTFGGSPITLGEFSLTD-KAREINKNSAILAREAAESF----ADSRT 133 Query: 116 LLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE 175 V GS+GP G++ + ++ +A + L++ G D + ET + + Sbjct: 134 RYVLGSMGP-------GTKLPSLGNIDYDSLEAALAEQARGLIEGGVDAILIETCQDTLQ 186 Query: 176 IEALA--------ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGI 227 I+A EL T P + T+ + L G + ++ V +G+ Sbjct: 187 IKAAVNGVKIARKELGTTTP---IFVQVTVETTGTLLVGPDIAAAATVIHSL-DVDLMGL 242 Query: 228 NCIALENTTAALQHLHGLTV-LP--LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW 284 NC A +H+ L+ P + V PN+G +T H+ A++A ++ ++ Sbjct: 243 NCATGPQEMA--EHVKWLSENWPRLISVQPNAGLPELVNGQT--HYPLTPAEMATWVERF 298 Query: 285 -QAAGARLIGGCCRTTPADIAALKA 308 G LIGGCC T+ AL A Sbjct: 299 ITEDGLNLIGGCCGTSTPHTEALDA 323 >UniRef50_Q5SKM5 5-methyltetrahydrofolate homocysteine S-methyltransferase n=5 Tax=Bacteria RepID=Q5SKM5_THET8 Length = 1185 Score = 64.7 bits (156), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 94/324 (29%), Positives = 137/324 (42%), Gaps = 62/324 (19%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSA-----KVLVEN-PELIREVHLDYYR 60 L+ALL++ L+ DGAM TEL+ R D A +VL PE++RE+HL Y Sbjct: 42 LKALLERP--LVFDGAMGTELQKRDLTPEDYGGEAYFGCPEVLNRTRPEVVREIHLAYLE 99 Query: 61 AGAQCAITASYQATPAGFAARGLDE-AQSKALIGKSVELARKAREAYLAENPQAGTLLVA 119 AGA+ T ++ A A GL+E A+ A +G AR ARE A +P VA Sbjct: 100 AGAEVIETNTFGALRHVLAEYGLEEAAEELAFLG-----ARIARE---AADPHGA--FVA 149 Query: 120 GSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEI--- 176 G++GP ++ G S +A ++ LL G DL+ ET + ++ Sbjct: 150 GALGPGTKLVSLG-------QISWDALYRAYKEAARGLLKGGVDLILLETAQDILQVRCA 202 Query: 177 -----EALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIA 231 EA+AE+ P T + + GT + +A L P V +G+NC Sbjct: 203 VLAVREAMAEVGREVP---LQVQVTFEATGTMLVGTDEQAALAALESLP-VDVVGMNCAT 258 Query: 232 ---LENTTAALQHLHG---LTVLPLVVYP-NSGEH--YDAVSK---TWHHHGEHCAQLAD 279 L ++ H ++ LP P N G YD + W H +A+ Sbjct: 259 GPDLMDSKVRYFAEHSTRFVSCLPNAGLPRNEGGRVVYDLTPEELAKW-----HLKFVAE 313 Query: 280 YLPQWQAAGARLIGGCCRTTPADI 303 Y G +GGCC T P I Sbjct: 314 Y-------GVNAVGGCCGTGPEHI 330 >UniRef50_Q01YW7 Methionine synthase (B12-dependent) n=5 Tax=Bacteria RepID=Q01YW7_SOLUE Length = 1185 Score = 64.3 bits (155), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 79/314 (25%), Positives = 139/314 (44%), Gaps = 32/314 (10%) Query: 8 RALLD--KQDILLLDGAMATELEARGCNLADSLWSAK-----VLVENPELIREVHLDYYR 60 +AL D +Q +L+LDGAM T + ++ + + V P++I+++H Y Sbjct: 9 KALNDSLEQRVLVLDGAMGTMIHQAPLSIETDYLGRENCPEILNVTRPDVIQDIHRQYLE 68 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGA T ++ T A L+E ++ L + +LAR+ + + + A VAG Sbjct: 69 AGADIIETNTFGGTRIALADNKLEE-RAYELNFAAAKLAREVADQF---STAAKPRFVAG 124 Query: 121 SVGPYGAYL-ADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEAL 179 S+GP L GS + +A + + + L++ GAD L ET + ++A Sbjct: 125 SIGPTNKDLNITGS-------TTFPEIKAAYYEQAKGLVEGGADYLLIETCFDTGSLKAG 177 Query: 180 AELLTAYPRARAW-----FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALE 233 + R A S T+ + + G + D + G +++ +G+NC + Sbjct: 178 LVAVEQLGRELAIQIPVVASVTIERTGTMLGGQQI-DALYASIGNHELLGVGMNCATGPD 236 Query: 234 NTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG-ARLI 292 T ++ L+ ++ + YPN+G + GE LA L ++ G + Sbjct: 237 LMTDHIRTLNEMSAHRISCYPNAG-----LPNAEGKFGETPDSLAAQLEKFANQGWLNFV 291 Query: 293 GGCCRTTPADIAAL 306 GGCC TTPA I A+ Sbjct: 292 GGCCGTTPAHIQAI 305 >UniRef50_A9KSG0 Homocysteine S-methyltransferase n=7 Tax=Clostridiales RepID=A9KSG0_CLOPH Length = 841 Score = 64.3 bits (155), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 67/305 (21%), Positives = 130/305 (42%), Gaps = 18/305 (5%) Query: 5 NPLRALLDKQDILLLDGAMATELEARG--CNLADSLWSAKVLVENPELIREVHLDYYRAG 62 N +A+++ Q I++LDGA + L+ G + W +++N E++ + +Y AG Sbjct: 4 NEFKAMIE-QKIVILDGATGSNLQNAGMPSGVCPETW----ILDNKEVLITLQKEYLYAG 58 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 ++ + + GL E + + + VEL+++A YL E + ++++AG + Sbjct: 59 TDILYAPTFTSNRIKLSEYGL-EHRIEEINHSLVELSKEAINRYLEETGETRSIMIAGDL 117 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 G L + D+ E ++ ++ L+ +G DLL ET+ + E A Sbjct: 118 TMTGEQLLPFG--KMDF----EELITIYKEQIGHLVSSGVDLLVVETMLSLQECRAAVIA 171 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIA-LENTTAALQH 241 S T + GT + + +L A+G+NC + + + ++ Sbjct: 172 AKEICELPVMVSLTFGEDNRTLYGTDPKTAMIVLQSLG-ADAVGVNCSSGPKKLSEVIEQ 230 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 + + +PL+ PN+G +T + A + G ++GGCC TTP Sbjct: 231 MLPVANVPLIAKPNAGLPKLVEDRTVFTM--DADEFAASCKIFLELGVSILGGCCGTTPK 288 Query: 302 DIAAL 306 I L Sbjct: 289 HINLL 293 >UniRef50_A8SP62 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=A8SP62_9FIRM Length = 808 Score = 63.9 bits (154), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 75/303 (24%), Positives = 126/303 (41%), Gaps = 25/303 (8%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 R L D + IL+LDGA T L G L + + ++E+ +++ ++ Y AG Sbjct: 6 FRKLFDDK-ILILDGATGTNLMDAGMPLG--VCPEQWILEHKQIMIDLQTAYLNAGTDIL 62 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 ++ GL + L+ + EL + +++A EN AG LVAG + G Sbjct: 63 YAPTFTCNRIKLNEYGL----ADNLVSMNSELVKLSQKA--VEN--AGHGLVAGDITMTG 114 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 L + + E ++ +++ L ++G DLL ET+ + +E A Sbjct: 115 EMLYPMGKLQ------FEELVDVYKEQIKVLDESGCDLLVVETMMSLAETRAAVIAANEV 168 Query: 187 PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGL 245 + S T + GT V +L V A+G+NC + ++ + + Sbjct: 169 SKLPIIASLTFNEDGRTLYGTDPVTAVNVLQNL-GVAAIGVNCSTGPDKMVELVKQMKSI 227 Query: 246 TVLPLVVYPNSG--EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADI 303 +P+ PN+G E D S E A + + AGA ++GGCC T P I Sbjct: 228 AFIPVFAKPNAGMPELVDDKSVYKMTPEEFAADMKLII----EAGAGMVGGCCGTRPDHI 283 Query: 304 AAL 306 AL Sbjct: 284 KAL 286 >UniRef50_Q5N5P4 5-methyltetrahydrofolate--homocysteine methyltransferase n=16 Tax=Cyanobacteria RepID=Q5N5P4_SYNP6 Length = 1190 Score = 63.9 bits (154), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 78/311 (25%), Positives = 126/311 (40%), Gaps = 41/311 (13%) Query: 16 ILLLDGAMATEL-------------EARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 +L+ DG M T L E GCN W ++ PE I VH + AG Sbjct: 16 VLVFDGGMGTTLQFQNLTAEDFGGPETEGCNE----W---LIRTKPEAIATVHRQFLEAG 68 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 A T ++ AT A GL++ + + A E E P+ VAGS+ Sbjct: 69 ADVIETDTFGATTIVLAEYGLEDHAYALNVEAAKLAKAIAAEFSTPEKPR----FVAGSM 124 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA---- 178 GP G H + +A + L + G DL ET + +I+A Sbjct: 125 GPTTKLPTLG-------HIGYDEMKASFAEQARGLWEGGVDLFIVETCQDVLQIKAALNG 177 Query: 179 LAELLTAYPRARAWF-SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTT 236 +AE+ + R S T+ + + G+ + ++A+L YP + LG+NC + Sbjct: 178 IAEIFSEKGDRRPLMVSVTMETTGTMLVGSDVAAMLAILEPYP-IDILGLNCATGPDRMV 236 Query: 237 AALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW-QAAGARLIGGC 295 +++L + + PN+G + H+ +L L ++ + G ++IGGC Sbjct: 237 EHIKYLSEHSPFVISCIPNAGIPENVGGHA--HYRLTPMELRMALHRFVEDLGVQVIGGC 294 Query: 296 CRTTPADIAAL 306 C T P IA L Sbjct: 295 CGTKPEHIAQL 305 >UniRef50_B6K6T6 Homocysteine methyltransferase n=1 Tax=Schizosaccharomyces japonicus yFS275 RepID=B6K6T6_SCHJY Length = 314 Score = 63.9 bits (154), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 84/322 (26%), Positives = 137/322 (42%), Gaps = 52/322 (16%) Query: 16 ILLLDGAMATELEARGCNLADS-LWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 +L+LDG + L ++ S LW+++ LV P+ +RE H ++ C + ++Y Sbjct: 1 MLVLDGGSTSILPKLPNDILKSKLWTSEALVRFPDQVREQHTEFL---GPCNVISTYTYQ 57 Query: 75 PAGFAARGLDEAQSKA----LIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLA 130 DEA+ A + + +EL +A++ ++ QA VA S+G Y A + Sbjct: 58 ---LDESIYDEAEENAPLDVVYSRGMELPLQAKQ----QSAQANR-FVAISLGSYAATVP 109 Query: 131 DGSEYRGDY-HCSVEAFQAFHRPRVEALLD------AGADLLACETLPNFSEIEALAEL- 182 EY Y + FH+ R+E + A D LA E+LP+ E A+ +L Sbjct: 110 GAMEYNMVYDEEDFDKLYNFHKRRLERMQRSNPKAFASIDFLAFESLPHVVEASAVLKLI 169 Query: 183 --LTAYPRARAWFSFTLRDSEHLS--DGTPLRDVVALLAGYPQVVALGINC--IALENTT 236 + Y + R W +FT E + DG L V+ Y + G+NC I+L Sbjct: 170 DDMKGYGK-RCWITFTCPSVEAIDRVDGI-LESVMKGPLTY--LWGTGVNCCHISLLPQI 225 Query: 237 AAL--QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAA------- 287 A + +H+ L V+YP+ W+ H +A +W A Sbjct: 226 ANVLEKHISPHPTLHAVLYPDG-------RGLWNAHPYSPNGIAPTPREWAQAVAPYVRL 278 Query: 288 --GARLIGGCCRTTPADIAALK 307 G L+GGCC TT + L+ Sbjct: 279 NDGKLLLGGCCETTVEHLQILR 300 >UniRef50_B1KCG4 Homocysteine S-methyltransferase n=52 Tax=Proteobacteria RepID=B1KCG4_BURCC Length = 313 Score = 63.2 bits (152), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 90/316 (28%), Positives = 115/316 (36%), Gaps = 45/316 (14%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 I +LDG M EL G WSA L+E P + H + AGA SY P Sbjct: 4 ITVLDGGMGRELARMGAPFRQPEWSALALMEAPHYVGLAHDAFIAAGADVITANSYAVVP 63 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 G + + ++ + A A P + VAGS+ P G Y Sbjct: 64 FHI---GEQRFRRDGVALAALAGQLARQAADRAVRP----VRVAGSLPPT------GGSY 110 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 R D + A A V+ LD DL ET EI+A+ L A R W SF Sbjct: 111 RPDLFDAARA-DAILATLVDG-LDPYVDLWLAETQSLTGEIDAVRRALGAN-RKPLWVSF 167 Query: 196 TLRD--SEHLSDGTPLRDVVALLAGYPQVV-----ALGINC-------IALENTTAALQH 241 TLRD G LR AL V AL NC A+E L Sbjct: 168 TLRDDVGADTGAGPVLRSGQALDEAIDAAVSARARALLFNCSQPEAMGAAIETVQRTLAG 227 Query: 242 LHGLTVLPLVVYPN----------SGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARL 291 + L + Y N + E D + G A + QW A GA++ Sbjct: 228 MGAGAALMIGAYANAFPPQRADARANEELDVLRGDIDPPG-----YAKWAEQWLALGAQI 282 Query: 292 IGGCCRTTPADIAALK 307 +GGCC P IAAL+ Sbjct: 283 VGGCCGIGPGHIAALR 298 >UniRef50_D2PQB9 Methionine synthase n=2 Tax=Actinomycetales RepID=D2PQB9_9ACTO Length = 1199 Score = 63.2 bits (152), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 96/327 (29%), Positives = 143/327 (43%), Gaps = 51/327 (15%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVEN---------------PELI 51 LR LLD++ I +LDGA T L+A NL + +++ P+LI Sbjct: 6 LRDLLDRR-IAVLDGAWGTMLQA--ANLTSEDYQGDRFLDHSHDVSGDPDLLNLMRPDLI 62 Query: 52 REVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGK-SVELARKAREAYLAEN 110 +VH Y AGA T ++ AT G A GL ++L+ + ++E AR AR+A Sbjct: 63 LDVHRQYLDAGADITTTNTFTATSIGQADYGL-----QSLVREMNLEGARLARQA----A 113 Query: 111 PQAGTLLVAGSVGPYGAYLA-----DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLL 165 +AG VAGSVGP L+ + YR S E + + ++ AL D G DLL Sbjct: 114 DEAGGRFVAGSVGPLNVTLSLSPRVEDPAYRA---VSFEQVRDSYAEQITALRDGGVDLL 170 Query: 166 ACETLPNFSEIE---ALAELLTAYPRARAWFS-FTLRDSEHLSDGTPLRDVVALLAGYPQ 221 ET+ F + A+A A P W S F LS T ++ P Sbjct: 171 LIETI--FDTLNCKAAIAAAREAAPELPLWISLFVDLSGRTLSGQTVEAWWNSIEHAEPL 228 Query: 222 VVALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADY 280 VV G+NC + + L + +PN+G + + + E Q A Sbjct: 229 VV--GVNCSLGARELRPHVADLARFADTYVASHPNAG-----LPNAFGGYDETPEQTAGM 281 Query: 281 LPQWQAAG-ARLIGGCCRTTPADIAAL 306 + ++ +G ++GGCC TTPA IA + Sbjct: 282 IGEFAESGLVNIVGGCCGTTPAHIAKI 308 >UniRef50_A8SCX4 Methylenetetrahydrofolate reductase n=3 Tax=Clostridiales RepID=A8SCX4_9FIRM Length = 605 Score = 63.2 bits (152), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 42/132 (31%), Positives = 63/132 (47%), Gaps = 2/132 (1%) Query: 176 IEALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENT 235 +EA+ L P A SF + + +G ++V +A V A+G+NC++ Sbjct: 154 LEAIRALKQTVPEAFVLVSFAVLPDGYTREGRYCAELVRRVAQSGVVDAVGLNCVSAPGA 213 Query: 236 TAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGC 295 AL G LPL V PN+G Y V++ + A L + + G R++GGC Sbjct: 214 MRALVQQLGDAGLPLSVMPNAG--YPVVARAQVRYQGKPEYFARELSRLASEGVRILGGC 271 Query: 296 CRTTPADIAALK 307 C TTP IAAL+ Sbjct: 272 CGTTPQHIAALR 283 >UniRef50_UPI0001C31EF9 homocysteine S-methyltransferase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31EF9 Length = 578 Score = 62.8 bits (151), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 88/305 (28%), Positives = 122/305 (40%), Gaps = 45/305 (14%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 ++LDG + TEL R + D W+ + LV + +R VH Y AG C + ++ A Sbjct: 24 VILDGGVGTELAPR-TDSDDRQWAGRALVAPEQSVRAVHRRYAEAG--CDVISTNTWALA 80 Query: 77 GFAARGLDEAQSKALIGKSVELARKAREAY---LAENPQAGTLLVAGSVGPYGAYLADGS 133 G A G A ++LAR A A + E ++G + VA S L D Sbjct: 81 GAARDGAPVGAGGAPPRHWMDLARTAVRAARAAIDEAGRSGEVAVAFS-------LNDEI 133 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPN-----FSEIEALAELLTAYPR 188 + R + F D DLL ETL + + +E L E T P Sbjct: 134 DTRDGLDTVRLLTRVFE--------DDPPDLLLLETLSSVRGSTYGTVETLLE--TGLP- 182 Query: 189 ARAWFSFTLRDSEHLSD------GTPLRDVVALLAGYPQVVALG---INCIALENTTAAL 239 W F R L G P D A + + +G INC+ ++ L Sbjct: 183 --VWLGFQ-RCRHGLCGVYGQHWGGPEGDAFGRAARRFEQMGVGALLINCVPPDHVDGML 239 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGE-HCAQLADYLPQWQAAGARLIGGCCRT 298 L T LPL V PN G H A W HG Q A + +W+A GA+L+GGCC Sbjct: 240 PWLRDFTDLPLGVSPNLG-HLSAAG--WQRHGSVEAEQYAQWALRWRAEGAQLVGGCCGV 296 Query: 299 TPADI 303 P + Sbjct: 297 RPEHV 301 >UniRef50_D2UDY2 Probable 5-methyltetrahydrofolate-homocysteine methyltransferase protein n=1 Tax=Xanthomonas albilineans RepID=D2UDY2_XANAL Length = 380 Score = 62.8 bits (151), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 91/349 (26%), Positives = 148/349 (42%), Gaps = 61/349 (17%) Query: 7 LRALLDKQDILLLDGAMAT--------ELEARGCNLADSLWSAK---------------- 42 L+AL ++ IL++DGAM T E + RG A SA+ Sbjct: 24 LQALSER--ILIIDGAMGTMIQRHGLQEADYRGDRFAAGYDSAQPPHVHGPGCDHAMHGH 81 Query: 43 --------VLVENPELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGK 94 +L+ PE+I E+H Y AGA T ++ AT A L+ + L Sbjct: 82 DLKGNNDLLLLTRPEVIAEIHSAYLEAGADLLETNTFNATAISQADYHLEHLVYE-LNKA 140 Query: 95 SVELARKAREAYLAENPQAG----TLLVAGSVGPYG--AYLADGSEYRGDYHCSVEAFQA 148 +AR +A A+ +AG V G +GP A ++ G + S + +A Sbjct: 141 GARVARDCCDAVEAQQARAGGPDKPRFVIGVLGPTSRTASISPDVNDPGYRNTSFDELRA 200 Query: 149 FHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYP-------RARAWFSFTLRDS- 200 +R ++ L+D GAD L ET+ F + A A L R S T+ D+ Sbjct: 201 TYREAIDGLIDGGADTLMVETI--FDTLNAKAALYAIEEVFDARGGRLPVMISGTITDAS 258 Query: 201 -EHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGE 258 LS T ++ G P +++G+NC + ++ ++ L + + +PN+G Sbjct: 259 GRTLSGQTAEAFYASVAHGRP--LSVGLNCALGAKDLRPHVETLARIADGYVSTHPNAG- 315 Query: 259 HYDAVSKTWHHHGEHCAQLADYLPQWQAAGA-RLIGGCCRTTPADIAAL 306 + + + E ++A L ++ AG L+GGCC TTPA I A+ Sbjct: 316 ----LPNAFGEYDETPEEMAATLKEFAEAGLLNLVGGCCGTTPAHIRAI 360 >UniRef50_C9M596 Vitamin B12-dependent methionine synthase family protein n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M596_9BACT Length = 808 Score = 62.4 bits (150), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 77/305 (25%), Positives = 125/305 (40%), Gaps = 38/305 (12%) Query: 4 NNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGA 63 +P R L +D ++ DGAM T L +RG L ++ + +PE + VH + AG+ Sbjct: 6 TSPSRRLTLGRDRIIFDGAMGTALGSRG--LRRGSLPEELNLSSPETVAAVHRSFLEAGS 63 Query: 64 QCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVG 123 T ++ A P+ A GL ++ + ++AR+ E + VA +G Sbjct: 64 DFITTNTFGAFPSRLAHAGLSVGP---VVRSACQIARREAERFGG--------FVALDIG 112 Query: 124 PYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGA---DLLACETLPNFSEIEALA 180 P G + E GD E +Q V +L AGA D + ET + +EI A A Sbjct: 113 PSGRLM----EPLGDATFD-EIYQG-----VCEVLHAGAAYCDAVLLETFTDLAEIRAAA 162 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI----ALENTT 236 + + + S G +L+G A G NC AL T Sbjct: 163 LAVRENCGLPLLATMSFEPSGRTFSGASAEACSLVLSGL-GASAFGTNCSAGPRALRET- 220 Query: 237 AALQHLHGLTVLPLVVYPNSG-EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGC 295 ++ + G +P++V PN+G + S + + + +W G ++GGC Sbjct: 221 --VRQICGACPVPVIVQPNAGLPEFSGSSVVYSAGPDEFQSVMGEFARW---GVAVLGGC 275 Query: 296 CRTTP 300 C TTP Sbjct: 276 CGTTP 280 >UniRef50_Q5E814 Methionine synthase n=458 Tax=Bacteria RepID=METH_VIBF1 Length = 1226 Score = 62.4 bits (150), Expect = 2e-08, Method: Composition-based stats. Identities = 77/319 (24%), Positives = 138/319 (43%), Gaps = 43/319 (13%) Query: 14 QDILLLDGAMAT--------ELEARG-------CNLADSLWSAKVLVENPELIREVHLDY 58 + ILL+DG M T E + RG C+L + + +++ P++IR++H Y Sbjct: 16 ERILLIDGGMGTMIQGYKFEEEDYRGERFNKWHCDLKGN--NDLLVLSQPQIIRDIHEAY 73 Query: 59 YRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLV 118 AGA T ++ AT A + E+ S+ + ++ +LAR+ + + + P V Sbjct: 74 LEAGADILETNTFNATTIAMADYDM-ESLSEEINFEAAKLAREVADKWTEKTPNK-PRYV 131 Query: 119 AGSVGPYGAYLADGSEYR--GDYHCSVEAFQAFHRPRVEALLDAGADLLACETL------ 170 AG +GP + + G + S + + AL+ G+DL+ ET+ Sbjct: 132 AGVLGPTNRTCSISPDVNDPGFRNVSFDELVEAYSESTRALIRGGSDLILIETIFDTLNA 191 Query: 171 --PNFSEIEALAELLTAYPRARAWFSFTLRDS--EHLSDGTPLRDVVALLAGYPQVVALG 226 +F+ EL P S T+ D+ LS T AL P ++ G Sbjct: 192 KACSFAVESVFEELDITLP---VMISGTITDASGRTLSGQTTEAFYNALRHVKP--ISFG 246 Query: 227 INC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ 285 +NC + + + L ++ + +PN+G + + + +A+++ +W Sbjct: 247 LNCALGPDELREYVSDLSRISECYVSAHPNAG-----LPNAFGEYDLSPEDMAEHVAEWA 301 Query: 286 AAG-ARLIGGCCRTTPADI 303 ++G LIGGCC TTP I Sbjct: 302 SSGFLNLIGGCCGTTPEHI 320 >UniRef50_D0MU48 Methionine synthase n=1 Tax=Phytophthora infestans T30-4 RepID=D0MU48_PHYIN Length = 1203 Score = 62.4 bits (150), Expect = 2e-08, Method: Composition-based stats. Identities = 89/328 (27%), Positives = 136/328 (41%), Gaps = 41/328 (12%) Query: 7 LRALLDKQDILLLDGAMAT--------ELEARGCNLADSLWSAK-----VLVENPELIRE 53 L AL+ KQ L+ DG M T E + R DS K + + P +I+E Sbjct: 28 LTALM-KQRTLIFDGGMGTMIQVHKFTEEDFRSERFKDSPCLVKGNNDLLSITQPHIIKE 86 Query: 54 VHLDYYRAG-AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQ 112 +H Y + G AQ T ++ T A D + + E A+ AREA E Q Sbjct: 87 IHKQYMQIGRAQLIGTNTFSGTTIAQA----DYQMEHLVYELNYESAKLAREA-ADEVTQ 141 Query: 113 AGTLL---VAGSVGPYGAYLA--DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLAC 167 LL VAGS+GP L+ E G + + + + +VE L+D G+D+L Sbjct: 142 LDPLLPRFVAGSIGPTNRTLSISPNVEDPGFRNVTFDELVDAYYTQVEGLVDGGSDVLLV 201 Query: 168 ETLPNFSEIEALAELLTAYPRARA-----WFSFTLRD--SEHLSDGTPLRDVVALLAGYP 220 ET+ + +A + Y A + S T+ D LS T V+L P Sbjct: 202 ETIFDTLNAKAAVFAINKYQEATGRKLPLFISGTIVDMSGRTLSGQTTEAFYVSLRHSKP 261 Query: 221 QVVALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLAD 279 +G+NC + LQ L + + VY N+G + + + A +A+ Sbjct: 262 --FCIGLNCALGANQMKPFLQRLANVAECFVSVYANAG-----LPNAMGGYDDTPAMMAE 314 Query: 280 YLPQWQAAG-ARLIGGCCRTTPADIAAL 306 Y ++ ++GGCC TTP I A+ Sbjct: 315 YCEEFSKDRLVNMMGGCCGTTPQHIQAI 342 >UniRef50_C0ADK0 Homocysteine S-methyltransferase n=1 Tax=Opitutaceae bacterium TAV2 RepID=C0ADK0_9BACT Length = 306 Score = 62.4 bits (150), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 89/303 (29%), Positives = 131/303 (43%), Gaps = 38/303 (12%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 L DGA T+L+ G +S + ++E P+ ++ VH Y AGA T ++ T Sbjct: 18 LQCDGATGTQLQQLGLRPGES--CERWVIEQPDRVKLVHQRYLDAGADLLTTNTFGGTTL 75 Query: 77 GFAARGL-DEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 AA G DEA ++ E+ R A A LA V G +GP+G L E Sbjct: 76 ALAAHGFTDEA-------RAAEINRAA--ARLAREVAGERAWVLGDMGPFGGIL----EP 122 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 G+ +V A + ALL+ GAD + ET+ + E +F Sbjct: 123 YGETESAVAAAAFRAQ--AAALLEGGADAILVETMSDPVEAALAVAAAREAGAQVVIATF 180 Query: 196 TLRDSEHLSD-----GTPLRDVV-ALLAGYPQVVALGINC---IALEN-TTAALQHLHGL 245 T + ++D GT + V A+L QVV G NC ++L++ A Q + Sbjct: 181 TFQHMAAVADFRTMMGTDVPAAVRAVLDAGAQVV--GANCGTELSLDDYALLAGQLVAAA 238 Query: 246 TVLPLVVYPNSGEHY---DAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPAD 302 P++V PN+G DA+S + A A + G R++GGCC TTPA Sbjct: 239 QGRPVIVQPNAGSPVRDGDAIS-----YRTTPADFAGAAACYLKLGVRIVGGCCGTTPAH 293 Query: 303 IAA 305 IAA Sbjct: 294 IAA 296 >UniRef50_UPI000196BD90 hypothetical protein CATMIT_02259 n=1 Tax=Catenibacterium mitsuokai DSM 15897 RepID=UPI000196BD90 Length = 791 Score = 62.4 bits (150), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 81/291 (27%), Positives = 130/291 (44%), Gaps = 34/291 (11%) Query: 17 LLLDGAMATELEARGCNLAD--SLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 L DG + L++ G + W+ + +PE I E++ Y AG T ++ A Sbjct: 12 LFWDGGTGSVLQSWGLQAGELPETWN----IIHPEKIVELNKGYLEAGCDIINTNTFGAN 67 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 + L+E ++ K+VE A+KARE L A L+A +GP G L E Sbjct: 68 RLKYPDN-LEE-----IVTKAVEHAKKARE--LTGRADA---LIALDLGPTGKLL----E 112 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 GD S + + +E AGAD++ ET+ + E++A +L A + Sbjct: 113 PLGD--LSFDDAVDIYAEVIEYGTKAGADVILIETMQDSYELKA--AVLAAKEHSDLPVC 168 Query: 195 FTLRDSEH---LSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPL 250 T+ E L+ GTP VVALL G + ALGINC + ++ + ++ P+ Sbjct: 169 ATVVFDEKGKMLTGGTP-ESVVALLEGL-HIDALGINCSLGPRQIKPFVERMIQVSSTPI 226 Query: 251 VVYPNSG-EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 +V PN+G D T++ A + + + ++GGCC TTP Sbjct: 227 IVTPNAGLPQTDDEGHTYYDM--SADDFALEMKEIASLNVHVLGGCCGTTP 275 >UniRef50_A4J5C2 Methylenetetrahydrofolate reductase n=5 Tax=Clostridiales RepID=A4J5C2_DESRM Length = 598 Score = 62.0 bits (149), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 63/306 (20%), Positives = 126/306 (41%), Gaps = 45/306 (14%) Query: 13 KQDILLLDGAMAT---ELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITA 69 K +IL+ DGAM T ++ + +++ + PE+I +H +Y AGA+ T Sbjct: 7 KNNILITDGAMGTYYAQITGKY-----NVFPEFANINEPEIIERIHTEYINAGAKLIKTN 61 Query: 70 SYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYL 129 ++ A + +++ K ++ ++LA K Q ++ +A S+GP Sbjct: 62 TFSANS---RVLKIPKSEVKKIVLAGLDLANKV--------AQGKSIFIAASIGPIPEMF 110 Query: 130 ADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRA 189 + D S++ ++ V+ L++ + ET FS++ L E +T Y + Sbjct: 111 ---DKMETDQENSLDEYKFI----VDIFLNSDIKIFMFET---FSDVSDLLE-ITKYIKV 159 Query: 190 RAWFSFTLRDSEHLSDGTPLRD-----VVALLAGYPQVVALGINC----IALENTTAALQ 240 + +F + +G + ++A + + A G NC L N+ L Sbjct: 160 KDSSAFIVTQFATTPEGFTRKGLSNKHIIAEVKKSKSIDAYGFNCGVGPTHLFNSLKKLN 219 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 + + PN+G Y + + ++ A+ + G +++GGCC TTP Sbjct: 220 FADDM----VAAAPNAG--YPEIVHERMVYIQNPNYFAEKMKDISGLGVKILGGCCGTTP 273 Query: 301 ADIAAL 306 I + Sbjct: 274 IHIEKM 279 >UniRef50_Q1CZ82 Homocysteine S-methyltransferase domain protein n=3 Tax=Deltaproteobacteria RepID=Q1CZ82_MYXXD Length = 326 Score = 61.6 bits (148), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 68/191 (35%), Positives = 85/191 (44%), Gaps = 28/191 (14%) Query: 136 RGDYHCSVEAFQ-----AFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRAR 190 RGD + EA AFH P VEAL AG D L + LP SE E LA L A A Sbjct: 130 RGDAYQPAEALPRREAAAFHAPHVEALSRAGVDFLVAQALPALSEAEGLA-LAMARTGAP 188 Query: 191 AWFSFTLRDSEHLSDGTPLRDVVALLAGYP--QVVALGINCI-------ALENTTAALQH 241 SF LR + L DGTPL + VA + P + A +NC+ L + AA Sbjct: 189 FLLSFVLRPTGTLLDGTPLAEAVARIDALPDARPTAYMVNCVHPSVFREGLSHQLAASPS 248 Query: 242 LHGLTVLPLVVYPN--SGEHYDAVSKTWHHHGEHCAQ---LADYLPQWQAA-GARLIGGC 295 L G V+ L + S E D ++ CA A + + A G R++GGC Sbjct: 249 L-GARVVGLQANTSRLSPEELDGRAEL------DCAPPDAFAREMARVHAELGTRVLGGC 301 Query: 296 CRTTPADIAAL 306 C T IAAL Sbjct: 302 CGTDERHIAAL 312 >UniRef50_B4DBI1 Homocysteine S-methyltransferase n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4DBI1_9BACT Length = 283 Score = 61.6 bits (148), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 89/309 (28%), Positives = 128/309 (41%), Gaps = 55/309 (17%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 + +L+ DGAM TEL A G L ++ V +P+L+R VH Y AGA+ T ++ Sbjct: 8 QHRVLIGDGAMGTELLAHGVPPGRCLE--ELCVSDPDLVRGVHERYIAAGARLIETNTFG 65 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELAR---KAREAYLAENPQAGTLLVAGSVGPYGAYL 129 A A G E + L + +LA+ + ++ Y VAG VGP G Sbjct: 66 ANAVRLAQYGC-EHRVGELNWTAAQLAKDVARGKDVY-----------VAGCVGPLGITA 113 Query: 130 ADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRA 189 + + D H E F ++ ALLD G ++ ET + E+ E A Sbjct: 114 EEAAARGIDRH---EVFT----DQIGALLDGGCRIIFLETFLDADELLVALEAKQALHHC 166 Query: 190 RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTV-L 248 T D + + + A +VV G NC+ + T AL L G+ Sbjct: 167 PVVAMLTSNDRQAFQAA-----IAKVRAAEAEVV--GANCV---DGTHALHLLDGMDPDA 216 Query: 249 PLVVYPNSGEHYDAVSKTWHHHGEHCAQLA-DYLPQWQAA--------GARLIGGCCRTT 299 L +P++G + KT H QLA P+ AA G RL+GGCC Sbjct: 217 TLAAFPSAG-----LPKT------HDQQLAYPTTPEVFAANARTLAERGVRLLGGCCGVG 265 Query: 300 PADIAALKA 308 P IAAL A Sbjct: 266 PQHIAALAA 274 >UniRef50_P74718 Slr1189 protein n=1 Tax=Synechocystis sp. PCC 6803 RepID=P74718_SYNY3 Length = 351 Score = 61.2 bits (147), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 60/213 (28%), Positives = 100/213 (46%), Gaps = 23/213 (10%) Query: 14 QDILLLDGAMATEL-EARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA------ 66 + I LLDG + TE+ RG +L ++A L+ +P L RE +Y+ A Sbjct: 47 EQIFLLDGGLETEMIFNRGFDL--PAFAAHTLLSDP-LGREALKNYFHGFLDLAKEKQFG 103 Query: 67 --ITA-SYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVG 123 I A +++A P G+ + + ++VE AR ++AY+ E LL+ G +G Sbjct: 104 FLIDAPTWRAQPFFAEELGVSLEEIRQANFRAVEFARALKQAYVNE---IQPLLINGLIG 160 Query: 124 PYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 P G Y G++ + EA Q +HR ++ L +AG DLL TL + +E + Sbjct: 161 PCG------DAYGGEHFSNAEAAQVYHRQQISWLAEAGVDLLGAFTLTSVNEAIGIVRAS 214 Query: 184 TAYPRARAWFSFTLRDSEHLSDGTPLRDVVALL 216 + + SFT+ L GT L + +A++ Sbjct: 215 QEFSLPVS-ISFTVETDGRLPTGTALSEAIAIV 246 >UniRef50_Q966F6 Putative uncharacterized protein T13G4.4 n=3 Tax=root RepID=Q966F6_CAEEL Length = 334 Score = 60.8 bits (146), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 67/259 (25%), Positives = 105/259 (40%), Gaps = 29/259 (11%) Query: 16 ILLLDGAMATELEARG--CNLADSL--WSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 + LLDG+M+++L G CN ++ WS + EL+ V+ + + + +Y Sbjct: 66 VRLLDGSMSSQLLRFGYDCNQQENKPHWSFPANADM-ELMENVYKSFLDLEVKVITSNTY 124 Query: 72 QATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAEN--------PQAGTLLVAGSVG 123 LD+ I ++ E R+ E Y E + + GSVG Sbjct: 125 HF------GSTLDKT-----IPENAE-KRELYEKYFEETCLKLCHLTTGSSDVEAWGSVG 172 Query: 124 PYGAYLADGSEYRGDYHCSVEAFQ-AFHRPRVEALL---DAGADLLACETLPNFSEIEAL 179 D SEY G Y EA + A+ ++ L + L ET+P+ E Sbjct: 173 TLATMYHDLSEYTGAYMDQSEAKKTAYDYFKIILTLFHNRSSIRKLIFETIPSADEGSVA 232 Query: 180 AELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAAL 239 ++L +P A SFT ++ L G + V + PQV+ +GINC N AL Sbjct: 233 LDVLQEFPEFEAVISFTFKEHGCLRHGEKITSVAQQMKQSPQVLGIGINCTDPNNVLPAL 292 Query: 240 QHLHGLTVLPLVVYPNSGE 258 L + VYPN G+ Sbjct: 293 NELQPFAFSEVFVYPNKGD 311 >UniRef50_A7RIN6 Predicted protein n=5 Tax=Eumetazoa RepID=A7RIN6_NEMVE Length = 434 Score = 60.1 bits (144), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 48/178 (26%), Positives = 91/178 (51%), Gaps = 26/178 (14%) Query: 11 LDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQC--AIT 68 L+ ++++ DG M+ LE R C + +W+ + +VE+PE +R++H ++ RAGA A T Sbjct: 17 LNNGEVIIGDGGMSHALEKR-CYVKIGVWTPECVVEHPEAVRQLHSEFLRAGADVIQAFT 75 Query: 69 ASYQATP---AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY 125 + Q P AG++ + + +++ +++ K E++ K A +G+L GS+ Sbjct: 76 FAMQDKPLVSAGYSYKWDEISRAGSILAK--EVSDKGEFAL-----SSGSLCETGSLFIK 128 Query: 126 GAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 G LA E + + R +V+ +D G DLL E + + E E + E++ Sbjct: 129 G--LATKEEIKQRF-----------RDQVKIFVDTGMDLLIAEYISHVQEAEWMVEVM 173 >UniRef50_B0PG09 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PG09_9FIRM Length = 406 Score = 60.1 bits (144), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 79/296 (26%), Positives = 118/296 (39%), Gaps = 39/296 (13%) Query: 17 LLLDGAMATELEARG--CNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 LLLDGA TE G + W+A E+P+++ V Y AG+ ++ A Sbjct: 13 LLLDGATGTEYMKAGLPSGVCVEQWAA----EHPDVVARVARGYADAGSDIVYAPTFLAN 68 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 GL E Q L K V ++A +LVAG + G E Sbjct: 69 AGNLKNYGLSE-QVIPLNRKIVSTVKQALAGR--------DVLVAGDMSTTGLMCEPFGE 119 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA--LAELLTAYPRARAW 192 + + A QA AL DAGA+LL ET+ SE A +A T P + Sbjct: 120 TEFVHLIGIYAEQA------SALADAGAELLVIETMSALSECRAAVIAARQTGLP---VF 170 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLV 251 + T+ G + + +L + A G+NC ++ + + LPL+ Sbjct: 171 LTMTVDAEGRTMWGDDVLASMIVLQDM-GISAFGLNCSQGPDDMVPLFERIAPYAKLPLI 229 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 PN+GE +S Q D + G ++IGGCC TTP ++AL+ Sbjct: 230 AKPNAGEP--PLSPV---------QFCDKCARLMRRGVKIIGGCCGTTPEYVSALR 274 >UniRef50_D0NMR8 Putative uncharacterized protein n=1 Tax=Phytophthora infestans T30-4 RepID=D0NMR8_PHYIN Length = 305 Score = 60.1 bits (144), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 76/311 (24%), Positives = 126/311 (40%), Gaps = 46/311 (14%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLV--ENPELIREVHLDYYRAGAQCAITASYQA 73 + LLDG EL ARG +WSA LV ++ +L+REVH + A A +Y Sbjct: 11 VTLLDGGTGEELFARGLPDDRFIWSATALVHEQHHKLLREVHTSFLDANADYITCNNYGV 70 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 TP G R + + A+ G+ +AR A + + P + + GS+ P Sbjct: 71 TP-GVGFRDEEIVRYTAVAGR---VARDACDRWTKTYPTSPKPKICGSLPPL-------- 118 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWF 193 +E+++A P E + A + TL F + LAE L++ A+ Sbjct: 119 ---------LESYRADKVPEHEEGVRLYA--MIARTLKPFVDC-YLAETLSSTQEAKMAL 166 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAGYP--QVVALGINCIALENTTAALQHLH-------- 243 + E++ + +V++ AG ++ A+ NC E+ AL+ LH Sbjct: 167 LGVQQAKENVC--KVVENVLSFTAGTSRTELQAILFNCSQPEDICKALKELHDDDNTQAS 224 Query: 244 --------GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGC 295 G L V P+ ++ + D++ QW GA ++GGC Sbjct: 225 LRSRGVRLGAYANRLTVIPDDWALAESSEPQAMRKDLAVERYRDFVSQWVELGADVVGGC 284 Query: 296 CRTTPADIAAL 306 C P IA++ Sbjct: 285 CGIGPEYIASI 295 >UniRef50_B0MM61 Putative uncharacterized protein n=1 Tax=Eubacterium siraeum DSM 15702 RepID=B0MM61_9FIRM Length = 414 Score = 60.1 bits (144), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 77/312 (24%), Positives = 136/312 (43%), Gaps = 42/312 (13%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 +SQ+ P+R + LLDG T LE G + ++ +A+ + NPE + E+ + Sbjct: 6 VSQDIPIRLPI------LLDGGTGTGLEKYGYD--HTVSTAQFVCANPEALIELQQGFLD 57 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVEL-ARKAREAYLAENPQAGTLLVA 119 AG+Q TA++ A A G+++ K+ +L A A+ Y + + +A L+A Sbjct: 58 AGSQILYTATHGANCENLKAYGVED--------KTEQLNAAAAKITYDSFHEKA---LIA 106 Query: 120 GSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEAL 179 G + G Y+ E GDY + + +R +V+A L D+ ET+P + A Sbjct: 107 GCLSSTGLYI----EPYGDY--TFTEIMSVYRQQVKA-LSPYCDMFVIETVPALWNMRA- 158 Query: 180 AELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAAL 239 A L + + + + GT + + +L + A G+NC + + + Sbjct: 159 AVLACKKENKPIIATMKVDEDGETAIGTNVLCTLLVLQAM-GISAFGLNCTSADLCPDII 217 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCA----QLADYLPQWQAAGARLIGGC 295 + +PL+V P S + GE + + A + + +GA + GGC Sbjct: 218 SEIAPYAKIPLIVKP---------SAVYEQDGERQSISPEEFAFAVKKSVLSGAEIAGGC 268 Query: 296 CRTTPADIAALK 307 C T IAAL+ Sbjct: 269 CGTGKEHIAALR 280 >UniRef50_A8LTT9 Homocysteine S-methyltransferase n=7 Tax=Rhodobacterales RepID=A8LTT9_DINSH Length = 308 Score = 59.7 bits (143), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 91/314 (28%), Positives = 132/314 (42%), Gaps = 53/314 (16%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 DI LLDG + EL R A LWS + L+ P+L+R VH D++ AGA+ A T +Y Sbjct: 2 DITLLDGGLGQEL-VRRAGRATPLWSMEALLNAPDLVRAVHDDFFAAGAEVATTNTYAVL 60 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG-AYLADGS 133 P AA D A A L +A A AG LVAG++GP G +Y D + Sbjct: 61 PDRLAA--FDMADQLA------PLTERACGIAAAARDAAGGGLVAGALGPLGFSYQPDKA 112 Query: 134 ---EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRAR 190 E + + V QA R+ D+L ET+ + +A ++ A + Sbjct: 113 PPPEQAAEIYAEVARLQA----RI-------VDVLVLETMSSVD--QARGGMMGAQVAGK 159 Query: 191 -AWFSFTLRDSE--HLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTV 247 W + ++ D++ L G PL + +L + L INC E + A+ L GL Sbjct: 160 PVWLALSVDDADGTKLRSGEPLAAISPVLETFSPDRVL-INCARPEAVSQAMPILAGL-- 216 Query: 248 LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ---------------AAGARLI 292 +P G + + ++ A + D L Q AAGA + Sbjct: 217 -----HPRIGGYANGFTRIESGFNRIGATV-DLLQARQDIGPAAYAAFAQAWVAAGATTV 270 Query: 293 GGCCRTTPADIAAL 306 GGCC PA I L Sbjct: 271 GGCCEIGPAHIEEL 284 >UniRef50_UPI00016C59CA 5-methyltetrahydrofolate--homocysteine S-methyltransferase n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C59CA Length = 1198 Score = 59.7 bits (143), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 81/329 (24%), Positives = 139/329 (42%), Gaps = 51/329 (15%) Query: 11 LDKQDILLLDGAMATELEARG---------------CNLADSLWSAKVLVENPELIREVH 55 L ++ + +LDG M T L NL+D+L + +P+ IRE+H Sbjct: 12 LARERVAILDGGMGTSLHKYKPTEKDWGYSSAGKSLMNLSDAL-----VYTHPDWIREIH 66 Query: 56 LDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARK-AREAYLAENPQAG 114 ++ AG T ++ A G G+ + Q + ++ LA++ A E A+ P+ Sbjct: 67 RGFFAAGCDGVETNTFNANAIGLGEFGMAD-QLDEINRLNIRLAKEVAAEFATADRPR-- 123 Query: 115 TLLVAGSVGPYGAY--LADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPN 172 V GSVGP L D + Y D+ +A++ R +E +DA + ET + Sbjct: 124 --FVIGSVGPGTKMPSLTDPAIYI-DFDSLADAYRTQFRVMIEERVDA----ILIETCFD 176 Query: 173 FSE-----IEALAELLTAYPRARAWFSFTL-RDSEHLSDGTPLRDVVALLAGYPQVVALG 226 E + A+ E+ A R T+ +++ + GT + + L ++ LG Sbjct: 177 ILEAKCAAVAAIEEMKRAGVRLPLMVQLTIINENKKMLPGTDIATGLVTLDPIDEIDVLG 236 Query: 227 INC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ 285 +NC + + ++HL + L V PN+G +T+ + +WQ Sbjct: 237 MNCGVGPDWMDEDVRHLSRHSRKLLSVLPNAGMPETRGDETYFPLD------PEGFAKWQ 290 Query: 286 AA-----GARLIGGCCRTTPADIAALKAR 309 GA +IGGCC TT A + A+ R Sbjct: 291 ERFVTEHGANIIGGCCGTTHAHLKAVCDR 319 >UniRef50_A6LKZ2 Homocysteine S-methyltransferase n=6 Tax=Bacteria RepID=A6LKZ2_THEM4 Length = 781 Score = 59.7 bits (143), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 68/293 (23%), Positives = 121/293 (41%), Gaps = 29/293 (9%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 I LDGA TE G + V N E++ + Y AG +T ++ A Sbjct: 22 IYFLDGAYGTEFFKLGFKEVIETLN----VTNSEMVYALQKAYVDAGVDFLLTNTFSANR 77 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 ++ + + K + +V++A+KAR + + + G + G ++ E Sbjct: 78 LKLSSLKV-KYNLKDINYNAVKIAKKAR--------KDKKVYILGDISSTGYLISPLGEL 128 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA----LAELLTAYPRARA 191 D EA++ F + + E LL++G D ET+ + E++A L +L P Sbjct: 129 TFD-----EAYEVF-KEQGEILLNSGIDGFILETMSDLKELKAAILALRDLSKDVP---I 179 Query: 192 WFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPL 250 T + GT + ++ + L V +GINC + E + L + P+ Sbjct: 180 IVQMTFDEDGVAVTGTSV-EIFSTLMNDLDVDVVGINCTLEPEKLLPVFKQLSNYSRKPI 238 Query: 251 VVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADI 303 V PN+G+ + + + A Y+ + GA ++GGCC T+P I Sbjct: 239 SVEPNAGKP-KLLRDGSIVYNTSPEKFALYMEDFVEFGANIVGGCCGTSPEHI 290 >UniRef50_B0TAJ7 Methionine synthase, putative n=1 Tax=Heliobacterium modesticaldum Ice1 RepID=B0TAJ7_HELMI Length = 807 Score = 59.3 bits (142), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 75/290 (25%), Positives = 111/290 (38%), Gaps = 24/290 (8%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 I L DGAM T L+A G L + +E+PE + +H Y GA+ T ++ AT Sbjct: 2 IKLFDGAMGTMLQAAG--LLPGACPERFNLEHPERVTAIHRRYVEMGAEIIETNTFGATR 59 Query: 76 AGFA-ARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 A R D+ ++ A +AGSVGP G +A E Sbjct: 60 LKLAHYRMADQVEAVCHAAVRAARAACGPATK-----------IAGSVGPTGKLIAPLGE 108 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 S E + ++ AL G D + ET+ + E+ A A + Sbjct: 109 L------SFEEAVDVYSEQISALAAVGVDYILIETIIDIQEMRAALLAAKAVAKVPVICQ 162 Query: 195 FTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLVVY 253 + GT LL V +G+NC + ++ + G T LP+ Sbjct: 163 LSFGADGRTVTGTDPATAAYLLEAMGADV-IGVNCSLGPAQLLPVIEAIAGATNLPISAQ 221 Query: 254 PNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADI 303 PN+G +T + A + P+ AAGA +GGCC TTP I Sbjct: 222 PNAGMPELIDGRTVFPMSPE--EFASWAPKLAAAGATYLGGCCGTTPEHI 269 >UniRef50_C4Z117 Methylenetetrahydrofolate reductase n=1 Tax=Eubacterium eligens ATCC 27750 RepID=C4Z117_EUBE2 Length = 595 Score = 58.9 bits (141), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 72/295 (24%), Positives = 113/295 (38%), Gaps = 40/295 (13%) Query: 13 KQDILLLDGAMATELEAR---GC--NLADSLWSAKVLVENPELIREVHLDYYRAGAQCAI 67 K +IL+ DGA T + G LA+ S +VL +H +Y AGA+ Sbjct: 15 KSEILVADGAFGTYYAKKYDTGSLPELANLQASDRVLA--------IHKEYIEAGAKIIR 66 Query: 68 TASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY-G 126 T ++ + A G DE ++ I +V++AR+A + +LVA +GP G Sbjct: 67 TNTFASNTVCLGA-GFDEVRNN--IKNAVDIAREA--------VKGTDVLVAADIGPIPG 115 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 + + +Y V F+ + G D+ ET P I+ E A Sbjct: 116 ENMIEKEHIEKEYVDIVNVFK-----------ECGVDIFVFETFPELGFIDKAIE--NAG 162 Query: 187 PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGL 245 F + + S G R ++ + A G NC + + +Q L Sbjct: 163 ENGFVITQFAINQFGYSSAGFSARKLIEEAGKNSYIDACGFNCGVGPGHMKKLVQSLINR 222 Query: 246 TVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 V PN+G + VS + A + + GA +IGGCC TTP Sbjct: 223 NDKYFAVLPNAG-YPQVVSGRMVFDDNNAAYFSQIMHDLAEDGADIIGGCCGTTP 276 >UniRef50_B7G6P4 Predicted protein n=2 Tax=cellular organisms RepID=B7G6P4_PHATR Length = 346 Score = 58.5 bits (140), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 80/344 (23%), Positives = 126/344 (36%), Gaps = 79/344 (22%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 + +LLDG E++ RG WSA L E+P+++R VH + AG+ T +Y Sbjct: 12 NRPFILLDGGTGREIQQRGGPFRQPEWSALALYEDPDIVRAVHESFLNAGSTAITTNTYA 71 Query: 73 ATPAGFAARGLDEAQSKA--LIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLA 130 P G D + A L ++ LA +A+ + + GS+ P Sbjct: 72 LVPYHI---GSDRFRKDAPRLFSLAISLAAEAKG-------DRQHVQILGSIPPV----- 116 Query: 131 DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLA---------CETLPNFSEIEALAE 181 C Q+F +++LD +L ET+ + E + Sbjct: 117 ----------CGSYEPQSFDEATAKSILDWFMPVLGDSPLVDAYLLETVGSTREARFYLQ 166 Query: 182 LLTAYPRARA-----------------WFSFTL------RDSEHLSDGTPLRDVV----- 213 + ++ +A A W SF + + HL G L V Sbjct: 167 YMQSFVKAVAESLDSLSNGTLAREKPVWLSFCIASHPGATQTPHLLTGETLTQAVHALIE 226 Query: 214 -ALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGE 272 LL V L +NC ++ A+Q LH + + PL + G + +A S + Sbjct: 227 EGLLTAATVPVVL-VNCCDVKLVLNAVQELHAV-LSPLGI--RVGAYPNAFSIPPPNAAN 282 Query: 273 HCAQLADY----------LPQWQAAGARLIGGCCRTTPADIAAL 306 H + DY W AGA ++GGCC P I AL Sbjct: 283 HTLRQVDYNVTPGRWAATAKSWINAGASVVGGCCGVGPKYITAL 326 >UniRef50_B1H0N5 Homocysteine S-methyltransferase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=B1H0N5_UNCTG Length = 801 Score = 58.2 bits (139), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 74/305 (24%), Positives = 118/305 (38%), Gaps = 42/305 (13%) Query: 13 KQDILLLDGAMATELEAR----GCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAIT 68 K IL++DGA TEL+ + G + + ++ ++ PE I +++ Y AG+ + Sbjct: 11 KSRILIMDGATGTELQKKKYLDGVEIPE-----EINIKFPERIADIYSSYINAGSDIILA 65 Query: 69 ASYQATPAGFAARGL-DEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGA 127 ++ A GL D+A +I ++L R+ + +VAG + G Sbjct: 66 NTFGANLIRLKQHGLLDKADD--IIKSGIDLIREI----------SSDTIVAGDISSIGE 113 Query: 128 YLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYP 187 Y+ D EA+ +F +V L GAD++ ET+ E +A Sbjct: 114 YIEPLGSLTFD-----EAYNSFAF-QVSLLQKHGADVIVIETMTEIKETKAAILAAKENF 167 Query: 188 RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL-T 246 T GT L+ +A+ A V ALG+NC A L + + T Sbjct: 168 DGAIIVQMTFSKDGVTVTGTDLKSFIAM-AESLGVDALGLNCSIGSRDLAELAKVLCVNT 226 Query: 247 VLPLVVYPNSG-----EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 LP+ PN+G +T E + Y G + GGCC T P Sbjct: 227 NLPISFKPNAGIPVLINRETCFPETKEEFIEASLKAYSY-------GVNMFGGCCGTNPE 279 Query: 302 DIAAL 306 I L Sbjct: 280 FIKIL 284 >UniRef50_C0ZBM1 5-methyltetrahydrofolate--homocysteine methyltransferase n=3 Tax=Bacillales RepID=C0ZBM1_BREBN Length = 1148 Score = 58.2 bits (139), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 87/323 (26%), Positives = 135/323 (41%), Gaps = 63/323 (19%) Query: 14 QDILLLDGAMATELEA-------------RGCNLADSLWSAKVLVENPELIREVHLDYYR 60 + IL+LDGAM T L+ GCN +L P++IR +H Y Sbjct: 11 RKILILDGAMGTMLQQANLTADDFGGEAYDGCNELLNLT-------RPDVIRSIHEKYLE 63 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAEN-PQAGTLLVA 119 AGA T ++ A A + E + I + LAR+A +AY E P+ VA Sbjct: 64 AGADIVETNTFGAASIVLAEYDVAEKDLEINIA-AARLAREAVDAYSTEEWPR----FVA 118 Query: 120 GSVGPYGAYLA--DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEI- 176 G++GP L+ G + E +A++R + + L+ G+D+L ET + + Sbjct: 119 GAMGPTTKTLSLTGGVTFE-------ELVEAYYR-QAKGLILGGSDVLLLETSQDTLNVK 170 Query: 177 -------EALAELLTAYPRARAWFSFTLRDSEHLSDGTPL--RDVVALLAGYPQV--VAL 225 +A EL P S T+ GT L +++ A + V++ Sbjct: 171 AGGIGIRKAFEELGQEIP---VMLSGTIEPM-----GTTLAGQNIEAFYISLEHIKPVSI 222 Query: 226 GINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW 284 G+NC E L+ L G+ + YPN+G + H+H E LA + + Sbjct: 223 GLNCATGPEFMRDHLRTLSGIAQCAVSCYPNAG----LPDENGHYH-ETPQGLASKMRAF 277 Query: 285 QAAG-ARLIGGCCRTTPADIAAL 306 G + GGCC TTP I A+ Sbjct: 278 AEQGWINVAGGCCGTTPDHIQAM 300 >UniRef50_A5TSW8 Methionine synthase n=9 Tax=Fusobacterium RepID=A5TSW8_FUSNP Length = 1082 Score = 57.8 bits (138), Expect = 4e-07, Method: Composition-based stats. Identities = 84/328 (25%), Positives = 124/328 (37%), Gaps = 69/328 (21%) Query: 13 KQDILLLDGAMATELE-----------ARGCNLADSLWSAKVLVEN-PELIREVHLDYYR 60 K+ IL+LDGAM T L+ A+GC ++L E P++I EVH Y Sbjct: 9 KERILVLDGAMGTVLQKYELTPEDFNGAKGC--------YEILNETRPDIIFEVHKKYIE 60 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGA T S+ L E + L KS E+AR A + + V G Sbjct: 61 AGADIIETNSFNCNAISLKDYHL-EDKVYDLAKKSAEIARDAVKE------SGKKVYVFG 113 Query: 121 SVGPYGAYLA----DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEI 176 S+GP L+ D R S + + + +V L+D G D + ET+ F + Sbjct: 114 SIGPTNKSLSFPVGDVPYKRA---VSFDEMKEVIKVQVAGLIDGGVDGILLETI--FDGL 168 Query: 177 EALAELLTAYP-------RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC 229 A A LL + S T+ L G + ++A L V + G NC Sbjct: 169 TAKAALLATEEVFEEKNVKLPISISATVNRQGKLLTGQSMESLIAAL-DRDSVTSFGFNC 227 Query: 230 -----------IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLA 278 I ++ T LH LP +G++ + K Sbjct: 228 SFGAKDLVPLVIKIKELTTKFVSLHANAGLP----NQNGDYVETAQK----------MRD 273 Query: 279 DYLPQWQAAGARLIGGCCRTTPADIAAL 306 D LP + ++GGCC T+ I A+ Sbjct: 274 DLLPLIENQAINILGGCCGTSYDHIRAI 301 >UniRef50_A4EKV4 Methionine synthase I n=4 Tax=Alphaproteobacteria RepID=A4EKV4_9RHOB Length = 339 Score = 57.8 bits (138), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 85/317 (26%), Positives = 129/317 (40%), Gaps = 39/317 (12%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADS--LWSAKVLVENPELIREVHLDYYR 60 N L LL +D L+ DGA T L G D+ +W+ V+ I ++ Sbjct: 2 MTNALSNLLKTRDWLMADGATGTNLFNMGLMSGDAPEMWN----VDETAKIIALYKGAAD 57 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AG+ +T S+ A + G E + K L + EL R+ +A ++VAG Sbjct: 58 AGSDIFLTNSFGANASRLKLHGA-EGRVKELNKAAAELGREVADA------SERVIVVAG 110 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 SVGP G +A + +VE F + E L GAD+L ET+ E A + Sbjct: 111 SVGPTGEIMAPMGSLT--HEIAVEMFH----EQAEGLKAGGADVLWVETISAPEEFAAAS 164 Query: 181 ELLTAYPR---ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTA 237 E F R L+ ++ V L Q G NC + Sbjct: 165 EAFALADMPWCGTMSFDTAGRTMMGLTSADMVKKVGKL---AHQPFGFGANCGV--GASD 219 Query: 238 ALQHLHGLT----VLPLVVYPNSG--EHYDAVSKTWH-HHGEHCAQLADYLPQWQAAGAR 290 L+ + G LP++ N+G +++D H H+ A +ADY + GA Sbjct: 220 LLRTVLGFAAADPTLPIIAKGNAGIPKYHDG-----HIHYDGTPALMADYAVLARDCGAT 274 Query: 291 LIGGCCRTTPADIAALK 307 +IGGCC TTP + A++ Sbjct: 275 IIGGCCGTTPEHLRAMR 291 >UniRef50_C8WWX3 Methylenetetrahydrofolate reductase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WWX3_ALIAD Length = 637 Score = 56.6 bits (135), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 78/302 (25%), Positives = 122/302 (40%), Gaps = 37/302 (12%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 ++ DGAM+T L G + + ++ + +P+L+ VH Y +G T ++ Sbjct: 20 VIFDGAMSTYLHQLGVPIGTPV--EQLNLTSPDLVARVHRRYVESGCTVLQTNTFMGNRI 77 Query: 77 GFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP------YGAYLA 130 GL ++L + VE+AR A + V G++GP YGA L Sbjct: 78 ALERHGLT-VDVQSLNRRGVEIARSAARDEAS---------VYGTMGPAMGGYRYGALLQ 127 Query: 131 DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE----IEALAELLTAY 186 D E R D V A QA EAL+ AG D L ET P+ E I A+ +L Sbjct: 128 D--EER-DLLARVYAEQA------EALVSAGIDGLILETFPDLEEALVAIAAVRPILGDL 178 Query: 187 PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGL 245 P + + + DG PL + + V +G+NC + + + Sbjct: 179 PLV---VNLSPEEIGVTRDGVPLAEAFRRIKAAGADV-VGLNCRLGPYGILRSYEQAGVA 234 Query: 246 TVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAA 305 P PN+G + + G+ A + + + G R +GGCC TTP I Sbjct: 235 ADGPYAAVPNAGILQRSEGDEIAYTGD-TADFSRLMLRIAQLGVRWLGGCCGTTPEYIRT 293 Query: 306 LK 307 L+ Sbjct: 294 LR 295 >UniRef50_B1HTR8 Methylenetetrahydrofolate reductase n=95 Tax=Bacilli RepID=B1HTR8_LYSSC Length = 647 Score = 56.6 bits (135), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 79/302 (26%), Positives = 122/302 (40%), Gaps = 37/302 (12%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K +L DGA+ T L G + V+ PELI ++H +Y AGA T +Y Sbjct: 40 KTHVLTADGAIGTVLYGYGLEYCHEEMN----VQRPELIEKIHREYIAAGADIIQTNTYG 95 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY-GAYLAD 131 A A GL E+ + ++ +A++A G V G++G G +D Sbjct: 96 ANAIKLARYGL-ESSVQRFNEAAITIAKRA--------AADGGQFVLGTIGGIRGIRKSD 146 Query: 132 GSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARA 191 + D +VE + LL D L ET +F E+ A ++L A Sbjct: 147 AT--LNDILKTVEE-------QASVLLAGNPDGLLLETYYDFEELTATLKMLRAKTNIPI 197 Query: 192 WFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPL 250 ++ + L +G L + L + +G+NC + +T A + + + Sbjct: 198 IAQVSMHEPGVLQNGMSLNIALHELEILGADI-VGVNCRLGPYHTIQAFEGVELPEKAFM 256 Query: 251 VVYPNSG----EHYDAVSKTW-HHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAA 305 YPN+ E V ++ + G +L D G RLIGGCC TTP IAA Sbjct: 257 SAYPNASLLDLEDGRVVYESEADYFGRAAVELRD-------QGVRLIGGCCGTTPKHIAA 309 Query: 306 LK 307 K Sbjct: 310 AK 311 >UniRef50_B0PF81 Methylenetetrahydrofolate reductase n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PF81_9FIRM Length = 582 Score = 56.2 bits (134), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 71/293 (24%), Positives = 113/293 (38%), Gaps = 44/293 (15%) Query: 17 LLLDGAMATELEARG-----CNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 L DGA T ++ C LA+ + P+ + ++H +Y +G T ++ Sbjct: 7 FLFDGAFGTYYFSKTGDEAPCELAN--------LTAPQTVLDIHREYAASGCAALKTNTF 58 Query: 72 QATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLAD 131 A P D + +I LA++A + EN G + A G AD Sbjct: 59 AANPVSIP----DSVRLNEVIAAGWSLAQRAAQ----EN---GARVFAD----IGGICAD 103 Query: 132 GSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE-ALAELLTAYPRAR 190 +E DY V F L+ GA ETL + +++ A+ + + P A Sbjct: 104 TAE--ADYLTVVRHF-----------LELGAQNFLFETLACYQDVQRAVGLIRQSVPDAT 150 Query: 191 AWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPL 250 SF + + G R + PQV A+G+NC + +L G V P+ Sbjct: 151 VIVSFAVSQDGYSRRGLYCRALFDQAESDPQVDAVGLNCSCGPSHMRSLLRALGQRVKPV 210 Query: 251 VVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADI 303 PN+G + + ++ A L GA ++GGCC TTP I Sbjct: 211 AAMPNAGYPSSLNGRVFFE--DNAGYFAQQLSALYMDGADILGGCCGTTPQHI 261 >UniRef50_P87138 Uncharacterized protein C57A7.07c n=1 Tax=Schizosaccharomyces pombe RepID=YDM7_SCHPO Length = 308 Score = 55.8 bits (133), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 70/320 (21%), Positives = 132/320 (41%), Gaps = 38/320 (11%) Query: 16 ILLLDGAMATELEARGCNLADS-LWSAKVLVENPELIREVHLDYYRAGAQCAI--TASYQ 72 +L+LDG L ++++S LW+++ LV PE++ + H ++ + C I T +YQ Sbjct: 1 MLMLDGGSTAILPKLPESISESRLWTSEALVRYPEIVVKHHEEFLKV---CDIISTFTYQ 57 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A ++ K + S+ L ARE N +A +G + A + Sbjct: 58 LD-ASIYDEKVEGVPLKQVYANSIGLPVYAREHLGLPNK-----YIALCLGSHAATIPGC 111 Query: 133 SEYRGDYH--CSVEAFQAFHRPRVEALLDAGA------DLLACETLPNFSEIEALAELLT 184 EY+ Y E FH+ R+EA+ + D +A E+LP+ +E E + +L+ Sbjct: 112 MEYKMIYDKPTDFEMLYNFHKNRIEAIQASNPKAFEKIDFIAFESLPHVTEAEVVCQLIQ 171 Query: 185 AYP--RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHL 242 R W + T + + + L + + +G+NC L + L Sbjct: 172 DMKGWSKRCWITCTCPERSTI-ERVSSIISKILSINHDSIWGIGVNCFHLSLLEPIAKML 230 Query: 243 HGL--TVLPLVVYPNSGEHYDAVSKTWHH-HGEHCAQLADYLPQWQAAGAR--------- 290 L + + ++YP+ Y T+ +H A + +W A+ Sbjct: 231 SSLLPSNITAILYPDGRGLYQNPDGTFSPGSTDHPAPSPE---EWSTITAKYSNLHNGNL 287 Query: 291 LIGGCCRTTPADIAALKARS 310 ++GGCC T ++ L+ ++ Sbjct: 288 ILGGCCETNYNHLSLLREKT 307 >UniRef50_B8I637 Methylenetetrahydrofolate reductase n=2 Tax=Clostridium RepID=B8I637_CLOCE Length = 615 Score = 55.5 bits (132), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 68/302 (22%), Positives = 119/302 (39%), Gaps = 40/302 (13%) Query: 10 LLDKQDILLLDGAMAT--ELEARG---CNLADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 + +D L DGA+ T L+ R C LA+ + E I +H +Y +AG Sbjct: 34 IFSNRDYFLFDGAIGTYYSLKYRSNTPCELAN--------INERENIFNIHSEYIQAGVN 85 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP 124 T ++ A G ++++ + +I ++A +A ++V +GP Sbjct: 86 AIKTNTFSANRFSL---GCNQSEVEKIIKSGYDIAVQA--------CSGQEVVVFADIGP 134 Query: 125 YGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 G + +Y V+ F L+ GA ET N + +A + Sbjct: 135 IPD--EKGINPKEEYIKIVDIF-----------LECGAKNFLFETFANTDILIGVAAYIR 181 Query: 185 -AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLH 243 P A SF + + +G D++ + V A+G+NCI+ L Sbjct: 182 LRLPEAVVVTSFAVYPDGYSKEGLFYVDLMDKMYASGLVDAVGLNCISGPAHMYRLIKKA 241 Query: 244 GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADI 303 + +++ PNSG Y + + ++ A+ L + G ++ GGCC TTP I Sbjct: 242 DIRGKSIIIMPNSG--YPGSERGRTVYSDNSEYYAEKLLDLKNLGVKIFGGCCGTTPKHI 299 Query: 304 AA 305 AA Sbjct: 300 AA 301 >UniRef50_UPI0000E47473 PREDICTED: hypothetical protein n=2 Tax=Strongylocentrotus purpuratus RepID=UPI0000E47473 Length = 176 Score = 55.5 bits (132), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 47/152 (30%), Positives = 71/152 (46%), Gaps = 9/152 (5%) Query: 20 DGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPAGFA 79 DG+M LE RG +A S W+ + ++ P+ ++++H ++ RAGA T +Y AT Sbjct: 25 DGSMLITLEKRGYVMAGS-WTPEATLQYPDAVKQLHREFLRAGADVIQTFTYCATEDNLK 83 Query: 80 ARGLDEAQSKALIGKSVELAR-KAREAYLA-ENPQAGTLLVAGSVGPYGAYLADGSEYRG 137 + E S + KSV ++ R LA E G LVAGSV AY DG+ + Sbjct: 84 MKNEHEKNSNDM--KSVSVSEINHRACDLAREVANEGGALVAGSVSNVNAYRKDGACHGA 141 Query: 138 DYHCSVEAFQAFHRPRVEALLDAGADLLACET 169 E Q + + + L+ G D L E Sbjct: 142 ----GKEFVQNEFKKQCDILVKKGVDFLLGEV 169 >UniRef50_B8J7W9 Methionine synthase n=3 Tax=Anaeromyxobacter RepID=B8J7W9_ANAD2 Length = 1150 Score = 54.7 bits (130), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 73/299 (24%), Positives = 126/299 (42%), Gaps = 27/299 (9%) Query: 17 LLLDGAMATELEARGCNLADSLWSAK------VLVENPELIREVHLDYYRAGAQCAITAS 70 L+ DGAM T+++ A+ + K + + P+LI E+H Y+ G T + Sbjct: 12 LVFDGAMGTQIQRHQLTAAE--FGGKEGANDLLTLTRPDLIEEIHARYFAVGCDVVETNT 69 Query: 71 YQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLA 130 + ++ GL + ++ R A ++P+ VAGS+GP G + Sbjct: 70 FGSSRLKLDEYGLGHRTYEVNCRAAILARRAADRYSTPDHPR----FVAGSIGPTGMLPS 125 Query: 131 DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRA- 189 G+ + +A + + + L++ G D L ET + E+ A A R Sbjct: 126 SSDPALGN--ITSDALERIFFEQAKGLVEGGVDALIIETQQDMLELRAAVLACDAVRREA 183 Query: 190 -RAWFSF---TLRDSE-HLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLH 243 R F TL D+ + GT + VA L P V A+G+NC + A+++ L Sbjct: 184 LRDVFVIAQPTLIDANGRMLLGTDIGSAVATLERLP-VDAVGLNCSTGPDEMRASVKALA 242 Query: 244 GLTVLPLVVYPNSG--EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 + V PN+G E+ D + + L ++ ++ G ++GGCC TTP Sbjct: 243 EKCSHFVSVLPNAGMPENVDGRAVYKLSPDDLARALVGFVAEY---GVDIVGGCCGTTP 298 >UniRef50_UPI00016C0A13 5-methyltetrahydrofolate--homocysteine methyltransferase, putative n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016C0A13 Length = 276 Score = 53.9 bits (128), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 78/305 (25%), Positives = 125/305 (40%), Gaps = 49/305 (16%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVEN---PELIREVHLDYYRAGAQCAITASY 71 +I LDGA+ G NL + SA V N P+L+ ++H +Y AGAQ I AS Sbjct: 2 NITFLDGAL-------GSNLLQT-ASANVFELNLTHPDLVAQLHREYVAAGAQ--IVASN 51 Query: 72 QATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYL-- 129 F + A++K +G+ +E + +++ A VA +GP A L Sbjct: 52 T-----FGVNRISAAKTKYAVGELIEAGLQIAFDAISDTDTAK---VAFDIGPLAALLEP 103 Query: 130 -ADGSEYR-GDYHCSVEAFQAFHRPR---VEALLDAGADLLACETLPNFSEIEALAELLT 184 D SE + + + A +P E +D LA N+ ++ LA ++ Sbjct: 104 FGDLSEEECSEIYAEILASGISQKPNYIFFETFMDVEMLKLAVAVADNY-DVPILAA-MS 161 Query: 185 AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIAL-ENTTAALQHLH 243 P + G + D +A ++ + VVA+G+NC N +Q Sbjct: 162 FLPVGKTIM------------GNSVDDFLAAMSKFKNVVAVGLNCSDTPTNLAKVVQEFA 209 Query: 244 GLTVLPLVVYPNSG--EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 + P+++ PN+G + D ++ E A Y Q A +GGCC TTP Sbjct: 210 AKSSWPIIIKPNAGLPQSVDG-EISYATDAEFFAAEMAYALQIPNA---YVGGCCGTTPL 265 Query: 302 DIAAL 306 I L Sbjct: 266 HIQQL 270 >UniRef50_C3XWR9 Putative uncharacterized protein n=5 Tax=Branchiostoma floridae RepID=C3XWR9_BRAFL Length = 683 Score = 53.5 bits (127), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 74/307 (24%), Positives = 131/307 (42%), Gaps = 42/307 (13%) Query: 12 DKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 D + ++ +G + E E RG L + +V++E+PEL+ +H ++ AG+ + +Y Sbjct: 12 DDETVICAEGYL-FEFERRG-YLQAGGYVPEVVIEHPELVEGLHREFVHAGSDVVLAFTY 69 Query: 72 QATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLAD 131 A G +E K + ++ LARK + GTL+ AG++ Y Sbjct: 70 YAHREKMRLIGREEDLEK-INRTALRLARKVAD-------DTGTLM-AGNICNLNIYDQA 120 Query: 132 GSEYRGDYHCSVEAFQAFHRPRVEALL-DAGADLLACETLPNFSEIEALAELLTAYPRA- 189 + G H A + ++E ++ + G D + ET F+E + E + Y + Sbjct: 121 DPSWEGRAH-------AMFKEQLEWIMEEGGCDFIVAETFFAFAEAKLALECVRKYAKGI 173 Query: 190 RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAAL---QHLHG-- 244 SF L+ + L DG ++D + LA V +G+NC TT + +G Sbjct: 174 PVVVSFNLKRGDDLIDGVLIQDALRRLAEAGADV-VGLNCGRGPATTLPVLEEARRNGIK 232 Query: 245 --LTVLPLVVYPNSGEHYDAVS-KTWHHHGEHC------------AQLADYLPQWQAAGA 289 L+ +P V Y E+ + ++ K G+ +Q+A Y + A G Sbjct: 233 TPLSFVP-VAYRTDDENPNMITLKDVDDKGKIAFPSDLDPWLCSRSQIASYTRKAHALGV 291 Query: 290 RLIGGCC 296 R +G CC Sbjct: 292 RFMGICC 298 Score = 49.7 bits (117), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 73/307 (23%), Positives = 131/307 (42%), Gaps = 42/307 (13%) Query: 12 DKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 D + I+ +G + E E RG L + +V++E+PEL+ +H ++ AG+ + +Y Sbjct: 345 DDETIICAEGYL-FEFERRGF-LKAGGFVPEVVIEHPELVEGLHREFVHAGSDVVLAFTY 402 Query: 72 QATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLAD 131 A G EA + + ++ LARK + GTL+ AG++ Y Sbjct: 403 YAHREKMRIIGR-EADLEKINRTALRLARKVAD-------DTGTLM-AGNICNLNIYDQA 453 Query: 132 GSEYRGDYHCSVEAFQAFHRPRVEALL-DAGADLLACETLPNFSEIEALAELLTAYPRA- 189 + G H + ++E ++ + G D + ET ++E + E + Y + Sbjct: 454 DPSWEGRAH-------GMFKEQLEWIMEEGGCDFILAETFFAYAEAKLALECVRKYAKGI 506 Query: 190 RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAAL---QHLHGLT 246 SF L+ + L DG ++D + LA V +G+NC TT + +G+ Sbjct: 507 PVVVSFNLKRGDDLIDGVLIQDALRRLAEAGADV-VGLNCGRGPATTLPVLEEAKQNGIK 565 Query: 247 VLPL----VVYPNSGEHYDAVS-KTWHHHGEHC------------AQLADYLPQWQAAGA 289 PL V Y E+ + ++ K + +G+ +Q+A Y + A G Sbjct: 566 T-PLAFVPVPYRTDDENPNFMTLKDVNDNGKIAFPLDLDPWLCSRSQIASYTRKAHALGV 624 Query: 290 RLIGGCC 296 R +G CC Sbjct: 625 RFMGICC 631 >UniRef50_C6VPC5 Methylenetetrahydrofolate reductase n=3 Tax=Lactobacillus plantarum RepID=C6VPC5_LACPJ Length = 618 Score = 53.1 bits (126), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 81/311 (26%), Positives = 131/311 (42%), Gaps = 37/311 (11%) Query: 13 KQDILLLDGAMATELEAR-GCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 +Q +L+ DGAM T L G N A + + +P+ I VH Y RAGA T +Y Sbjct: 8 QQRVLVADGAMGTLLYGNYGINSAFENLN----LTHPDTILRVHRSYIRAGADIIQTNTY 63 Query: 72 QATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLAD 131 A L + Q + +V++A ARE A++P + + G++G Sbjct: 64 AANRLKLTRYDLQD-QVTTINQAAVKIAATAREH--ADHP----VYILGTIGGLA----- 111 Query: 132 GSEYRGDYHCSVE-----AFQAFHRPRVEALLDAGA-DLLACETLPNFSEIEALAELLTA 185 GD +V+ A ++ ALL D + ET + E+ A +++ A Sbjct: 112 -----GDTDATVQRATPATIAASVTEQLTALLATNQLDGILLETYYDLPELLAALKIVKA 166 Query: 186 YPRARAWFSFTLRDSEHLSDGTPLRD-VVALLAGYPQVVALGINC-IALENTTAALQHLH 243 + + ++ L +GT D +V L A V+ G NC + + ++L Sbjct: 167 HTDLPVITNVSMLAPGVLRNGTSFTDAIVQLNAAGADVI--GTNCRLGPYYLAQSFENLA 224 Query: 244 GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP--- 300 + L VYPN+G + GE + +Y +++ G +IGGCC TTP Sbjct: 225 IPANVKLAVYPNAGLPGTDQDGAVVYDGE-PSYFEEYAERFRQLGLNIIGGCCGTTPLHT 283 Query: 301 -ADIAALKARS 310 A + L RS Sbjct: 284 SATVRGLSNRS 294 >UniRef50_A5N923 Methylenetetrahydrofolate reductase n=2 Tax=Clostridium kluyveri RepID=A5N923_CLOK5 Length = 590 Score = 53.1 bits (126), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 64/300 (21%), Positives = 115/300 (38%), Gaps = 45/300 (15%) Query: 13 KQDILLLDGAMAT------ELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 K+ L+ DGAM T + C LA+ + + I ++H +Y AG Sbjct: 4 KEKPLIFDGAMGTYYPRISKDPLPKCELAN--------IYDRNTILKIHREYIEAGCMAI 55 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 T ++ A + D + K +I E+A++A + +LV +GP Sbjct: 56 KTNTFGANKVSLES---DFNKVKEVIINGYEIAKEA--------AKDTEVLVFADIGPI- 103 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 +L Y G ++ V+ L+ GA ET + + ++E + Sbjct: 104 PFLESMDLYEG------------YKEIVDLFLELGAKYFIFETFSSDEYLREISEYIKGK 151 Query: 187 -PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL 245 P A F + + G + ++ + P + A G NC + LQ++ Sbjct: 152 DPEAYILMEFAVSPEGYTRVGKSGKKLIENILKIPTIDACGFNCFS--GPYHLLQYIKTF 209 Query: 246 TV--LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADI 303 + + V PNSG ++T+ + + A + + G ++GGCC TTP I Sbjct: 210 NIGNETISVMPNSGYPTVIDNRTFFDNTKE--YFAQRMLEIAKQGVSILGGCCGTTPEFI 267 >UniRef50_A8TIL6 Methionine synthase I n=3 Tax=Proteobacteria RepID=A8TIL6_9PROT Length = 344 Score = 52.8 bits (125), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 83/315 (26%), Positives = 134/315 (42%), Gaps = 41/315 (13%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADS--LWSAKVLVENPELIREVHLDYYRAGAQ 64 L LL ++ L+ DGAM T L A G DS LW+ VE+P+ + VH D+ AG+ Sbjct: 5 LTDLLAERGHLIADGAMGTNLFALGLETGDSPELWN----VEHPDRVATVHRDFLEAGSD 60 Query: 65 CAITASYQATPAGFAARGLDEAQSKA--LIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 +T S+ + F + L AQ + L + +AR+ +A+ A + LVAGS+ Sbjct: 61 IVLTNSFGGS--SFRLK-LHHAQDRVRELNAAAAGIARREVDAHAASTGR--RTLVAGSI 115 Query: 123 GPYGA-YLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 GP G ++ G+ + EA + L + GAD+L ET+ E+ Sbjct: 116 GPTGELFIPLGAL-------TAEAAADAFAEQAAGLAEGGADVLWIETMSAPEEV----- 163 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQV-----VALGINCIALENTT 236 L AR + + + T + A + Q VA+G NC Sbjct: 164 LAAVAGGARTGLPIVVTMTFDTNARTMMGVTPVEFANFAQALEHTPVAIGANCGV--GPA 221 Query: 237 AALQHLHGLTVLP----LVVYPNSG-EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARL 291 + + G+T ++ N G Y + ++ E +A Y + AGAR+ Sbjct: 222 ELVDTILGITAAAPGAVVIAKGNCGIPQYVEGAIVYNGSPE---AMAAYAQLVRDAGARI 278 Query: 292 IGGCCRTTPADIAAL 306 +GGCC +T + A+ Sbjct: 279 VGGCCGSTAIHVKAI 293 >UniRef50_A1DJI9 Homocysteine S-methyltransferase, putative n=4 Tax=Trichocomaceae RepID=A1DJI9_NEOFI Length = 313 Score = 52.8 bits (125), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 70/250 (28%), Positives = 108/250 (43%), Gaps = 32/250 (12%) Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAR-EAYLAENPQAGTLLVAGSVGPYGAYLAD 131 A P G +A L E A V LA++AR +A EN ++++G++GP D Sbjct: 80 AQPMGLSADKLLELNHAA-----VRLAKEARNKAVGGENNIP--VVISGTMGPLRDAYED 132 Query: 132 GSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARA 191 SE ++E + +R +VE L DAG D+LA T+ N +E A+ EL R Sbjct: 133 TSE-----SITLEDAREGYREQVEVLADAGVDMLAIMTVTNLNEAIAVVELAKEV-RLPV 186 Query: 192 WFSFTLRDSEHLSDG----TPLRDVVALLAGYPQVVALGINCIALENTTAAL----QHLH 243 SF++ L G + +R V GY VV G+NC +AAL + + Sbjct: 187 VVSFSIESDGRLLGGRSLESAIRTVDEKTGGY--VVYYGVNCAHPVRISAALRDVPEDVR 244 Query: 244 GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLAD----YLPQWQAAGARLIGGCCRTT 299 G + L+ S + +D + + + D LP ++IGGCC T Sbjct: 245 GR--IGLIKGNASLKSHDELDNSGTLDRGDISAFTDGFEGVLP--LVPNVKVIGGCCGTD 300 Query: 300 PADIAALKAR 309 + A+ R Sbjct: 301 EEHLEAIAKR 310 >UniRef50_C3Y7W3 Putative uncharacterized protein n=3 Tax=Branchiostoma floridae RepID=C3Y7W3_BRAFL Length = 415 Score = 52.8 bits (125), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 80/320 (25%), Positives = 125/320 (39%), Gaps = 66/320 (20%) Query: 20 DGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPAGFA 79 DG+ LE RG LA W+ +V++E+PE ++ +H +Y AGA +++ ++ Sbjct: 64 DGSYVFTLERRGYVLAGP-WTPEVVIEHPEAVKSLHREYLHAGADVLQASTFYSSDDKLT 122 Query: 80 ARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYRGDY 139 G + S+ + K EL KA L E +L+ G++ P +YL DG Sbjct: 123 MPGHE--ASRTITCK--ELNDKAC-TILKEVAGDADVLLCGAMSPVPSYL-DGK------ 170 Query: 140 HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSFT--- 196 E Q + ++EA ++ D L E L + E E + EL+ + A T Sbjct: 171 --GKEVVQREYAKQMEAFIEHDLDFLLAEFLGHVEEAEWVIELMKTKGKPVACTLRTGPK 228 Query: 197 ------------LRDSEHLSD----------GTPLRDVVAL--------LAGYPQVVALG 226 +R +E +D T L+ + A+ L+ Y V LG Sbjct: 229 GDCAGVAAGECAVRMAEAGADVVGVNCQYDPNTCLKTMEAMKTELDKRGLSPYLMVQPLG 288 Query: 227 INCIALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQA 286 +C +EN Q L P + P ++A H A Y Sbjct: 289 FHCPEVENEDEGYQM---LPECPFALEPRQLTRFEA----------HAFARAAY-----D 330 Query: 287 AGARLIGGCCRTTPADIAAL 306 G R IGGCC P I A+ Sbjct: 331 LGVRYIGGCCGFEPHHIRAI 350 >UniRef50_B5JEM8 Homocysteine S-methyltransferase, putative n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JEM8_9BACT Length = 318 Score = 52.4 bits (124), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 74/316 (23%), Positives = 130/316 (41%), Gaps = 50/316 (15%) Query: 13 KQDILLLDGAMATELEARGCNLADS--LWSAKVLVENPELIREVHLDYYRAGAQCAITAS 70 ++ +L+ DGAM T+L A G S +W+ + +P+ + + Y +G+ C IT + Sbjct: 27 REKVLVSDGAMGTQLMAAGLEAGGSGEMWN----LTHPDRVLAIQKRYVDSGSNCIITNT 82 Query: 71 YQATPAGFAARGLDEAQSKALIGKS-VELARKAREAYLAENPQAGTLLVAGSVGPYGAYL 129 + G R A I ++ V++AR A VGP G + Sbjct: 83 FGGN--GLMLRRHGHFDQLAEINQAAVKIARDAFGGGEGFVFG--------DVGPVGGVM 132 Query: 130 ADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY--P 187 E GD + A R +++AL++AGAD + ET + +EI E Y P Sbjct: 133 ----EPYGDLKPADVAEGV--RIQIQALVEAGADAIIIETQTDLNEIALGIEAAKKYGAP 186 Query: 188 RARAWFSFTLRDSEHLSDGTPLRDVVALL--AGYPQVVALGINCIALENTTAA------- 238 A ++ D H DG+ R ++ + ++ LG++ +AL T Sbjct: 187 CIIASLAY---DKSH--DGSFFRTMMGISPEKAAEELTDLGVDILALNCGTGIDMTVARE 241 Query: 239 -LQHLHGLTVLPLVVYPNSG----EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIG 293 ++ + + PN+G E+ AV K + ++ L G ++G Sbjct: 242 IIEEYKDNSDAFTMAQPNAGLPVLENMKAVYK------QTPTEMVSTLDALLEEGVNIVG 295 Query: 294 GCCRTTPADIAALKAR 309 GCC + P I A++ + Sbjct: 296 GCCGSNPDHIRAIREK 311 >UniRef50_C1XT53 Methionine synthase (B12-dependent) n=2 Tax=Meiothermus RepID=C1XT53_9DEIN Length = 1223 Score = 52.0 bits (123), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 83/330 (25%), Positives = 132/330 (40%), Gaps = 63/330 (19%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAK--------VLVENPELIREVHLDY 58 LRAL ++ +L+ DGAM TE+ + AD + A+ + P++I +H Y Sbjct: 18 LRALSER--VLIYDGAMGTEIFKYDLSAAD--YGAEQYNGCPEMLNRTRPDVIEAIHKSY 73 Query: 59 YRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARK-AREAYLAENPQAGTLL 117 AGA T ++ A P GL EA++ L LAR+ A E + P+ Sbjct: 74 LEAGADVIETNTFGAFPHVLVEYGL-EAEAYELAFAGAHLARRVADEHSTPDQPR----F 128 Query: 118 VAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEI- 176 VAGS+GP ++ G S E +R + LLD G DL+ ET + ++ Sbjct: 129 VAGSMGPGTKLISLG-------QISWEGLFESYRVCAQGLLDGGVDLILIETCQDILQVR 181 Query: 177 -------EALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC 229 A+ ++ P T+ + + GT + +L P + +G NC Sbjct: 182 CAVLAARRAMKDVGREVP---IQVQVTMETTGTMLVGTDDAAALTVLEALP-IDVVGFNC 237 Query: 230 ------------IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQL 277 EN T + L PN+G + + + A+L Sbjct: 238 ATGPDLMDTHVRFFCENATRWVSCL-----------PNAGLPRNEGGRVVYDL--TPAEL 284 Query: 278 ADYLPQW-QAAGARLIGGCCRTTPADIAAL 306 A + ++ G ++GGCC T P I AL Sbjct: 285 ARWQQKFVNEYGLNVVGGCCGTGPEHIRAL 314 >UniRef50_A7SKT1 Predicted protein n=4 Tax=Eumetazoa RepID=A7SKT1_NEMVE Length = 1178 Score = 51.2 bits (121), Expect = 4e-05, Method: Composition-based stats. Identities = 79/315 (25%), Positives = 126/315 (40%), Gaps = 47/315 (14%) Query: 17 LLLDGAMAT--------ELEARGCNLADSLWSAK-----VLVENPELIREVHLDYYRAGA 63 ++ DG M T E + RG + S K + + P+ I ++H Y AGA Sbjct: 1 MIFDGGMGTMIQKLHLEEADFRGEEFKNHPKSLKGNNDLLSITKPDAILDIHKGYLEAGA 60 Query: 64 QCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVG 123 T ++ T A GL++A + L S E+A++A AY VAG++G Sbjct: 61 DFVETNTFSGTKIAQADYGLEDAAYR-LNRASAEVAKRA--AYEVTASTGVEKFVAGAMG 117 Query: 124 PYGAYLADGS--EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 P L+ E G + + + + + LLD G D+L ET+ F A A Sbjct: 118 PTNRTLSISPTVECPGFRNVTFDELVDAYTEQARGLLDGGVDVLLVETI--FDTANAKAA 175 Query: 182 LLT-------AYPRARAWFSFTLRDS--EHLSDGTPLRDVVALLAGYPQVVALGINC-IA 231 L Y + S T+ D LS T V+++ P + +G+NC + Sbjct: 176 LFAIDQLFEKEYSPVPVFVSGTIVDKSGRTLSGQTTESFVISVSHSSP--MCIGLNCALG 233 Query: 232 LENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARL 291 ++ + T + YPN+G + T+ + E +A +L AR Sbjct: 234 AVEMRPFIEAVGMNTEAYTICYPNAG-----LPNTFGDYDETPETMAKHLK------AR- 281 Query: 292 IGGCCRTTPADIAAL 306 CC TTP I A+ Sbjct: 282 ---CCGTTPEHIRAI 293 >UniRef50_A0Z513 Putative uncharacterized protein n=1 Tax=marine gamma proteobacterium HTCC2080 RepID=A0Z513_9GAMM Length = 306 Score = 51.2 bits (121), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 83/310 (26%), Positives = 116/310 (37%), Gaps = 45/310 (14%) Query: 16 ILLLDGAMATELEARGCNLAD-SLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 I LLDG M EL R LWS +V+++ PEL+ VH D+ AGA+ +Y T Sbjct: 5 ITLLDGGMGQELIRRSSAAKPHPLWSLQVMMDEPELVANVHRDFCLAGARVICLNTYSVT 64 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGA-YLADGS 133 G + L+ + +LAR +A + V S+ P A YL Sbjct: 65 RHRL-QMGNELPDLPELLKHAGDLARAGIQASGLHG-----IDVVASLPPLTASYLKQSP 118 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW- 192 + R V+ L ETL + +E EA +L A A Sbjct: 119 LSPTQMKDEYKELMELQRHHVDGFL--------AETLSSVAEGEA---VLRAAQEAGTGV 167 Query: 193 -FSFT--------LRDSEHLSDG----TPLRDVVALL-AGYPQVVALGINCI--ALENTT 236 +FT LR E L D PL+ + +L P+ + G+ + A E Sbjct: 168 HLAFTVQDEDGTLLRSGELLEDALRACVPLKPLSVILNCSIPEAIDQGLPLVAQATEIFG 227 Query: 237 AALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCC 296 A H +T L G D ++ A D QW GA ++GGCC Sbjct: 228 AYANGFHSVTAL------KPGGTVDVLTA---REDLTPAAYTDMSLQWLELGASILGGCC 278 Query: 297 RTTPADIAAL 306 PA I AL Sbjct: 279 EVGPAHIEAL 288 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_Q47690 Homocysteine S-methyltransferase n=56 Tax=Bacter... 456 e-127 UniRef50_O31463 Homocysteine S-methyltransferase ybgG n=13 Tax=B... 353 5e-96 UniRef50_Q1WRK4 Homocysteine S-methyltransferase n=10 Tax=Lactob... 348 2e-94 UniRef50_C4V3M8 Homocysteine S-methyltransferase n=5 Tax=Bacteri... 333 5e-90 UniRef50_C6VP70 Homocysteine methyltransferase n=7 Tax=Bacteria ... 331 2e-89 UniRef50_Q0BQM8 Homocysteine S-methyltransferase n=1 Tax=Granuli... 324 2e-87 UniRef50_B2VXK3 Homocysteine S-methyltransferase n=2 Tax=Pleospo... 321 2e-86 UniRef50_Q8LAX0 Homocysteine S-methyltransferase 3 n=52 Tax=Embr... 321 3e-86 UniRef50_D1HYS9 Whole genome shotgun sequence of line PN40024, s... 320 3e-86 UniRef50_Q4Q0C9 Homocysteine S-methyltransferase, putative n=3 T... 320 3e-86 UniRef50_C1F5Y3 Homocysteine S-methyltransferase n=1 Tax=Acidoba... 319 8e-86 UniRef50_B3S7K9 Putative uncharacterized protein n=1 Tax=Trichop... 317 2e-85 UniRef50_B1MXY2 Homocysteine S-methyltransferase n=1 Tax=Leucono... 316 4e-85 UniRef50_D1BKY6 Homocysteine S-methyltransferase n=3 Tax=Veillon... 316 5e-85 UniRef50_B9E9X6 Putative uncharacterized protein n=1 Tax=Macroco... 316 8e-85 UniRef50_A5VKC8 Homocysteine S-methyltransferase n=10 Tax=Lactob... 316 1e-84 UniRef50_D2RKX3 Homocysteine S-methyltransferase n=2 Tax=Acidami... 315 1e-84 UniRef50_C3ZEE1 Putative uncharacterized protein n=1 Tax=Branchi... 310 5e-83 UniRef50_B0NWZ7 Putative uncharacterized protein n=1 Tax=Clostri... 308 2e-82 UniRef50_A8KB71 Zgc:171603 protein n=4 Tax=Clupeocephala RepID=A... 308 2e-82 UniRef50_Q5M5A7 Homocysteine S-methyltransferase (S-methylmethio... 307 3e-82 UniRef50_UPI0000DB6B54 PREDICTED: similar to CG10621-PA n=3 Tax=... 302 1e-80 UniRef50_B0RCV4 Homocysteine s-methyltransferase n=15 Tax=Actino... 301 2e-80 UniRef50_A8YVC8 Homocysteine S-methyltransferase n=2 Tax=Lactoba... 301 2e-80 UniRef50_Q4S116 Chromosome 1 SCAF14770, whole genome shotgun seq... 301 3e-80 UniRef50_Q5PNQ3 Novel protein containing a homocysteine S-methyl... 301 3e-80 UniRef50_Q1GBT8 Homocysteine S-methyltransferase n=2 Tax=Lactoba... 295 9e-79 UniRef50_UPI000050FD2A homocysteine methyltransferase n=1 Tax=Br... 294 3e-78 UniRef50_Q2F5Q8 Homocysteine S-methyltransferase n=3 Tax=Endopte... 294 3e-78 UniRef50_A6G853 Homocysteine methyltransferase n=3 Tax=Bacteria ... 293 4e-78 UniRef50_C4R8J7 S-adenosylmethionine-homocysteine methyltransfer... 290 5e-77 UniRef50_B0K7W0 Homocysteine S-methyltransferase n=13 Tax=Firmic... 288 2e-76 UniRef50_A4J6L9 Methionine synthase (B12-dependent) n=1 Tax=Desu... 286 6e-76 UniRef50_Q2LWJ5 5-methyltetrahydrofolate--homocysteine methyltra... 286 7e-76 UniRef50_C8X6V8 Homocysteine S-methyltransferase n=14 Tax=Actino... 285 9e-76 UniRef50_A0APQ1 CG10623 protein n=22 Tax=Drosophila RepID=A0APQ1... 283 4e-75 UniRef50_Q9VJ32 CG10621 n=19 Tax=Neoptera RepID=Q9VJ32_DROME 280 5e-74 UniRef50_A4XIN5 Methylenetetrahydrofolate reductase n=1 Tax=Cald... 280 5e-74 UniRef50_C9KQD5 Vitamin B12-dependent methionine synthase family... 278 1e-73 UniRef50_Q49V93 Putative homocysteine S-methyltransferase n=1 Ta... 278 2e-73 UniRef50_B9W8L8 Homocysteine S-methyltransferase, putative (S-me... 277 2e-73 UniRef50_B9L045 Methylenetetrahydrofolate reductase n=1 Tax=Ther... 277 2e-73 UniRef50_A8Q150 Probable homocysteine S-methyltransferase, putat... 276 8e-73 UniRef50_C1F3L2 Methylenetetrahydrofolate reductase n=2 Tax=Bact... 275 1e-72 UniRef50_A0Q0N0 5-methyltetrahydrofolate--homocysteine methyltra... 275 1e-72 UniRef50_C8W2L3 Homocysteine S-methyltransferase n=1 Tax=Desulfo... 275 1e-72 UniRef50_Q5ZBZ6 Os01g0772900 protein n=3 Tax=Magnoliophyta RepID... 274 2e-72 UniRef50_B9MN09 Methylenetetrahydrofolate reductase n=2 Tax=root... 272 8e-72 UniRef50_Q2JJL4 Methionine synthase n=30 Tax=Bacteria RepID=Q2JJ... 272 1e-71 UniRef50_B8CZI7 Homocysteine S-methyltransferase n=1 Tax=Halothe... 269 8e-71 UniRef50_C3WBE7 Methionine synthase n=1 Tax=Fusobacterium mortif... 269 1e-70 UniRef50_A5IKF3 Methionine synthase (B12-dependent) n=6 Tax=Ther... 268 2e-70 UniRef50_Q0AX05 Methionine synthase (B12-dependent) n=1 Tax=Synt... 267 3e-70 UniRef50_A4XIN4 Homocysteine S-methyltransferase n=1 Tax=Caldice... 267 3e-70 UniRef50_Q67LG1 5-methyltetrahydrofolate S-homocysteine methyltr... 266 7e-70 UniRef50_C5MAR2 Putative uncharacterized protein n=1 Tax=Candida... 266 7e-70 UniRef50_A9B073 Methionine synthase n=2 Tax=Bacteria RepID=A9B07... 266 8e-70 UniRef50_A6TTI3 Homocysteine S-methyltransferase n=6 Tax=Firmicu... 266 8e-70 UniRef50_C4XYV2 Putative uncharacterized protein n=1 Tax=Clavisp... 265 1e-69 UniRef50_D0NSW2 Homocysteine S-methyltransferase, putative n=1 T... 265 1e-69 UniRef50_Q01QP4 Methylenetetrahydrofolate reductase n=2 Tax=Acid... 265 2e-69 UniRef50_B9MN08 Homocysteine S-methyltransferase n=1 Tax=Anaeroc... 264 2e-69 UniRef50_A3ERA3 5-methyltetrahydrofolate--homocysteine methyltra... 264 3e-69 UniRef50_C0QRY9 Methionine synthase n=3 Tax=Bacteria RepID=C0QRY... 263 5e-69 UniRef50_D1CBD0 Methylenetetrahydrofolate reductase n=1 Tax=Ther... 263 6e-69 UniRef50_C6HW85 5-methyltetrahydrofolate--homocysteine methyltra... 263 7e-69 UniRef50_B3E428 Methionine synthase n=91 Tax=Bacteria RepID=B3E4... 262 8e-69 UniRef50_B6YR37 Cobalamin-dependent methionine synthase n=1 Tax=... 262 8e-69 UniRef50_C6DY72 Homocysteine S-methyltransferase n=10 Tax=Desulf... 262 9e-69 UniRef50_Q7M929 S-METHYLTRANSFERASE n=1 Tax=Wolinella succinogen... 262 1e-68 UniRef50_C3XLV5 S-methyltransferase n=2 Tax=Helicobacter RepID=C... 261 2e-68 UniRef50_C6JIG3 Methionine synthase n=3 Tax=Fusobacterium RepID=... 260 3e-68 UniRef50_D1BQ67 Homocysteine S-methyltransferase n=4 Tax=Veillon... 260 3e-68 UniRef50_C7NB07 Methionine synthase n=6 Tax=Leptotrichia RepID=C... 260 3e-68 UniRef50_A9B657 Methylenetetrahydrofolate reductase n=1 Tax=Herp... 260 3e-68 UniRef50_C1XT53 Methionine synthase (B12-dependent) n=2 Tax=Meio... 260 3e-68 UniRef50_UPI00017B4C9F UPI00017B4C9F related cluster n=1 Tax=Tet... 260 5e-68 UniRef50_Q01YW7 Methionine synthase (B12-dependent) n=5 Tax=Bact... 259 7e-68 UniRef50_UPI000180BE5F PREDICTED: similar to CG10623 CG10623-PA ... 259 9e-68 UniRef50_B4DST3 cDNA FLJ56487, highly similar to Methionine synt... 259 1e-67 UniRef50_Q6BZK6 DEHA2A00616p n=1 Tax=Debaryomyces hansenii RepID... 259 1e-67 UniRef50_Q99707 Methionine synthase n=289 Tax=cellular organisms... 259 1e-67 UniRef50_B7ZLW7 MTR protein n=1 Tax=Homo sapiens RepID=B7ZLW7_HUMAN 258 1e-67 UniRef50_C6D4G9 Methylenetetrahydrofolate reductase n=12 Tax=cel... 257 3e-67 UniRef50_C6W4B8 Methionine synthase n=4 Tax=Bacteria RepID=C6W4B... 257 4e-67 UniRef50_Q5SKM5 5-methyltetrahydrofolate homocysteine S-methyltr... 255 1e-66 UniRef50_UPI0001BC43AA B12-dependent methionine synthase n=1 Tax... 255 1e-66 UniRef50_C0ZBM1 5-methyltetrahydrofolate--homocysteine methyltra... 255 1e-66 UniRef50_A9KSG0 Homocysteine S-methyltransferase n=7 Tax=Clostri... 255 2e-66 UniRef50_A5DCB0 Putative uncharacterized protein n=2 Tax=Pichia ... 254 2e-66 UniRef50_B9XKW8 Methylenetetrahydrofolate reductase n=1 Tax=bact... 254 2e-66 UniRef50_Q5E814 Methionine synthase n=458 Tax=Bacteria RepID=MET... 253 5e-66 UniRef50_B8FX16 Homocysteine S-methyltransferase n=2 Tax=Desulfi... 253 6e-66 UniRef50_B8I366 Homocysteine S-methyltransferase n=1 Tax=Clostri... 253 7e-66 UniRef50_A9FZY9 Methylenetetrahydrofolate reductase n=1 Tax=Sora... 252 9e-66 UniRef50_Q6AL45 Related to 5-methyltetrahydrofolate--homocystein... 252 1e-65 UniRef50_A3TGH3 Homocysteine methyltransferase n=1 Tax=Janibacte... 252 1e-65 UniRef50_Q146H9 Methionine synthase (B12-dependent) n=21 Tax=cel... 252 1e-65 UniRef50_C1SMZ8 5-methyltetrahydrofolate--homocysteine methyltra... 252 2e-65 UniRef50_A9A1I5 Homocysteine S-methyltransferase n=2 Tax=Thaumar... 251 2e-65 UniRef50_C3PEG0 Homocysteine S-methyltransferase n=3 Tax=Coryneb... 251 2e-65 UniRef50_UPI0001C311AB homocysteine S-methyltransferase n=1 Tax=... 251 3e-65 UniRef50_O06745 5,10-methylenetetrahydrofolate reductase n=78 Ta... 250 3e-65 UniRef50_A6QBA6 5-methyltetrahydrofolate--homocysteine methyltra... 250 3e-65 UniRef50_B3QGP3 Methionine synthase n=71 Tax=cellular organisms ... 250 4e-65 UniRef50_B5YB64 5-methyltetrahydrofolate-homocysteine methyltran... 250 6e-65 UniRef50_C4LIL8 5-methyltetrahydrofolate--homocysteinemethyltran... 247 3e-64 UniRef50_B8DYM9 Homocysteine S-methyltransferase n=1 Tax=Dictyog... 247 5e-64 UniRef50_C3RK90 Homocysteine S-methyltransferase n=3 Tax=Bacteri... 246 6e-64 UniRef50_A8SP62 Putative uncharacterized protein n=2 Tax=Clostri... 246 7e-64 UniRef50_Q6C0D6 YALI0F25641p n=1 Tax=Yarrowia lipolytica RepID=Q... 246 8e-64 UniRef50_B6GAW1 Putative uncharacterized protein n=1 Tax=Collins... 245 1e-63 UniRef50_Q5N5P4 5-methyltetrahydrofolate--homocysteine methyltra... 245 2e-63 UniRef50_A5UPF4 Methionine synthase (B12-dependent) n=5 Tax=Chlo... 244 3e-63 UniRef50_A6LKZ2 Homocysteine S-methyltransferase n=6 Tax=Bacteri... 243 4e-63 UniRef50_A5TSW8 Methionine synthase n=9 Tax=Fusobacterium RepID=... 243 5e-63 UniRef50_B0TAJ7 Methionine synthase, putative n=1 Tax=Heliobacte... 243 5e-63 UniRef50_C7JFY7 Methionine synthase n=8 Tax=Acetobacter pasteuri... 242 8e-63 UniRef50_C0QY88 5-methyltetrahydrofolate--homocysteine methyltra... 242 9e-63 UniRef50_Q2LQ11 Methylenetetrahydrofolate reductase n=1 Tax=Synt... 242 1e-62 UniRef50_UPI00016C59CA 5-methyltetrahydrofolate--homocysteine S-... 242 2e-62 UniRef50_D1Y627 Homocysteine S-methyltransferase n=1 Tax=Pyramid... 242 2e-62 UniRef50_Q55786 Methionine synthase n=14 Tax=Cyanobacteria RepID... 241 2e-62 UniRef50_A1AKP7 Methylenetetrahydrofolate reductase n=10 Tax=Des... 241 2e-62 UniRef50_D0MU48 Methionine synthase n=1 Tax=Phytophthora infesta... 240 3e-62 UniRef50_Q08985 Homocysteine S-methyltransferase 2 n=17 Tax=Sacc... 240 5e-62 UniRef50_Q49775 Methionine synthase n=41 Tax=Bacteria RepID=METH... 240 7e-62 UniRef50_C1EAX2 Predicted protein n=36 Tax=cellular organisms Re... 240 7e-62 UniRef50_A8SPV0 Methylenetetrahydrofolate reductase n=2 Tax=Clos... 239 9e-62 UniRef50_A5DTG6 Putative uncharacterized protein n=1 Tax=Loddero... 238 1e-61 UniRef50_A7TSR2 Putative uncharacterized protein n=1 Tax=Vanderw... 238 2e-61 UniRef50_C4GEB2 Putative uncharacterized protein n=1 Tax=Shuttle... 238 2e-61 UniRef50_A7SKT1 Predicted protein n=4 Tax=Eumetazoa RepID=A7SKT1... 237 5e-61 UniRef50_UPI0001AEC485 homocysteine S-methyltransferase family p... 237 5e-61 UniRef50_D2UDY2 Probable 5-methyltetrahydrofolate-homocysteine m... 237 6e-61 UniRef50_C4QA25 Putative uncharacterized protein n=1 Tax=Schisto... 237 6e-61 UniRef50_C9RQ92 Methionine synthase n=1 Tax=Fibrobacter succinog... 236 7e-61 UniRef50_D1B7X8 Homocysteine S-methyltransferase n=1 Tax=Therman... 235 1e-60 UniRef50_A3LQC9 AdoMet-homocysteine methyltransferase n=1 Tax=Pi... 235 1e-60 UniRef50_C0D4W7 Putative uncharacterized protein n=3 Tax=Clostri... 235 2e-60 UniRef50_Q30ZI4 Methionine synthase (B12-dependent) n=14 Tax=Des... 234 3e-60 UniRef50_D2RMA2 Homocysteine S-methyltransferase n=13 Tax=Bacter... 234 3e-60 UniRef50_B9DIA5 Methylenetetrahydrofolate reductase n=10 Tax=Sta... 234 3e-60 UniRef50_B2A781 Homocysteine S-methyltransferase n=1 Tax=Natrana... 232 1e-59 UniRef50_A7VWF8 Putative uncharacterized protein n=1 Tax=Clostri... 232 1e-59 UniRef50_Q024B4 Homocysteine S-methyltransferase n=2 Tax=Bacteri... 232 2e-59 UniRef50_Q1NSQ8 Methylenetetrahydrofolate reductase n=3 Tax=Delt... 232 2e-59 UniRef50_B8J7W9 Methionine synthase n=3 Tax=Anaeromyxobacter Rep... 231 2e-59 UniRef50_B2UNQ8 Methionine synthase n=1 Tax=Akkermansia muciniph... 231 2e-59 UniRef50_UPI000196BD90 hypothetical protein CATMIT_02259 n=1 Tax... 231 2e-59 UniRef50_Q8DUN2 Methylenetetrahydrofolate reductase n=12 Tax=Str... 231 3e-59 UniRef50_Q1AXR8 Methylenetetrahydrofolate reductase n=2 Tax=Bact... 230 4e-59 UniRef50_C0QE32 Methionine synthase I, cobalamin-binding domain ... 230 7e-59 UniRef50_Q15S12 Homocysteine S-methyltransferase n=1 Tax=Pseudoa... 229 9e-59 UniRef50_B4RRL7 Homocysteine S-methyltransferase family protein ... 228 2e-58 UniRef50_C6VPC5 Methylenetetrahydrofolate reductase n=3 Tax=Lact... 228 2e-58 UniRef50_C7N1R7 Methionine synthase (B12-dependent) n=5 Tax=Bact... 227 6e-58 UniRef50_D0LSQ2 Methylenetetrahydrofolate reductase n=1 Tax=Hali... 226 7e-58 UniRef50_C8WWX3 Methylenetetrahydrofolate reductase n=2 Tax=Alic... 225 1e-57 UniRef50_A6DGP4 5-methyltetrahydrofolate--homocysteine methyltra... 225 2e-57 UniRef50_A1SWN6 Homocysteine S-methyltransferase n=1 Tax=Psychro... 225 2e-57 UniRef50_D1N227 Methylenetetrahydrofolate reductase n=1 Tax=Vict... 225 2e-57 UniRef50_B1H0N5 Homocysteine S-methyltransferase n=1 Tax=uncultu... 225 2e-57 UniRef50_C6LEJ3 Vitamin B12-dependent methionine synthase family... 224 3e-57 UniRef50_Q753B4 AFR410Wp n=1 Tax=Eremothecium gossypii RepID=Q75... 223 4e-57 UniRef50_D2R929 Homocysteine S-methyltransferase n=1 Tax=Pirellu... 223 4e-57 UniRef50_C1C2Y0 Homocysteine S-methyltransferase 1 n=1 Tax=Calig... 222 1e-56 UniRef50_Q2S678 Vitamin B12-dependent methionine synthase family... 222 1e-56 UniRef50_UPI0001BC6543 5-methyltetrahydrofolate--homocysteine me... 221 3e-56 UniRef50_A5ZUF2 Putative uncharacterized protein n=2 Tax=Clostri... 220 4e-56 UniRef50_D2PQB9 Methionine synthase n=2 Tax=Actinomycetales RepI... 220 4e-56 UniRef50_C9M596 Vitamin B12-dependent methionine synthase family... 220 4e-56 UniRef50_B1HTR8 Methylenetetrahydrofolate reductase n=95 Tax=Bac... 220 5e-56 UniRef50_B7I892 Homocysteine S-methyltransferase family protein ... 220 5e-56 UniRef50_C5E3E4 KLTH0H12716p n=1 Tax=Lachancea thermotolerans CB... 220 6e-56 UniRef50_C7LX76 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 218 1e-55 UniRef50_UPI0001BCEC92 bifunctional homocysteine S-methyltransfe... 218 3e-55 UniRef50_B8M2P0 Homocysteine S-methyltransferase, putative n=1 T... 217 4e-55 UniRef50_B2AAZ0 Predicted CDS Pa_1_5620 n=2 Tax=Sordariales RepI... 217 6e-55 UniRef50_C3MDS4 Homocysteine S-methyltransferase, putative n=12 ... 216 9e-55 UniRef50_Q0TQI2 Homocysteine S-methyltransferase family protein ... 215 2e-54 UniRef50_C4Z117 Methylenetetrahydrofolate reductase n=1 Tax=Euba... 215 2e-54 UniRef50_B7AQD9 Methylenetetrahydrofolate reductase n=1 Tax=Bact... 215 2e-54 UniRef50_B8PAR1 Predicted protein (Fragment) n=1 Tax=Postia plac... 214 3e-54 UniRef50_A8M0Q1 Homocysteine S-methyltransferase n=3 Tax=Actinom... 213 8e-54 UniRef50_B0PG09 Putative uncharacterized protein n=1 Tax=Anaerot... 213 9e-54 UniRef50_Q28RZ7 Homocysteine S-methyltransferase n=13 Tax=Rhodob... 211 3e-53 UniRef50_B7VQ49 Homocysteine S-methyltransferase family protein ... 211 3e-53 UniRef50_Q2RU64 Methionine synthase (B12-dependent) n=10 Tax=cel... 210 5e-53 UniRef50_C8VHP4 Homocysteine S-methyltransferase (Eurofung) n=5 ... 210 6e-53 UniRef50_A7VPD0 Methylenetetrahydrofolate reductase n=1 Tax=Clos... 210 6e-53 UniRef50_A1WU24 Homocysteine S-methyltransferase n=7 Tax=Proteob... 209 9e-53 UniRef50_B1A1E6 Homocysteine methyltransferase (Fragment) n=1 Ta... 209 1e-52 UniRef50_B5JEM8 Homocysteine S-methyltransferase, putative n=1 T... 208 2e-52 UniRef50_A4J5C2 Methylenetetrahydrofolate reductase n=5 Tax=Clos... 207 5e-52 UniRef50_A5N923 Methylenetetrahydrofolate reductase n=2 Tax=Clos... 206 9e-52 UniRef50_B4DBI1 Homocysteine S-methyltransferase n=1 Tax=Chthoni... 205 2e-51 UniRef50_C4GEB4 Methylenetetrahydrofolate reductase n=1 Tax=Shut... 205 2e-51 UniRef50_A9GUQ7 Putative homocysteine S-methyltransferase family... 203 7e-51 UniRef50_A6S563 Putative uncharacterized protein n=2 Tax=Sclerot... 203 9e-51 UniRef50_A8SCX4 Methylenetetrahydrofolate reductase n=3 Tax=Clos... 202 1e-50 UniRef50_B9NLU8 Homocysteine S-methyltransferase family protein ... 202 2e-50 UniRef50_D2S8U0 Homocysteine S-methyltransferase n=12 Tax=Actino... 201 2e-50 UniRef50_C0ADK0 Homocysteine S-methyltransferase n=1 Tax=Opituta... 201 3e-50 UniRef50_UPI000190A21A homocysteine S-methyltransferase n=2 Tax=... 201 3e-50 UniRef50_B7G9Z1 Predicted protein n=1 Tax=Phaeodactylum tricornu... 201 4e-50 UniRef50_B6AUX0 Homocysteine S-methyltransferase n=1 Tax=Rhodoba... 200 5e-50 UniRef50_A3JFK5 Putative uncharacterized protein n=1 Tax=Marinob... 200 6e-50 UniRef50_D1Z559 Whole genome shotgun sequence assembly, scaffold... 200 6e-50 UniRef50_A8TIL6 Methionine synthase I n=3 Tax=Proteobacteria Rep... 200 7e-50 UniRef50_C6UN88 Putative B12-dependent methionine synthase n=1 T... 199 9e-50 UniRef50_B6BT42 Homocysteine S-methyltransferase 4, putative n=1... 199 9e-50 UniRef50_A8N5L5 Putative uncharacterized protein n=1 Tax=Coprino... 199 1e-49 UniRef50_A4WQF1 Homocysteine S-methyltransferase n=39 Tax=Alphap... 199 1e-49 UniRef50_Q4FMM0 Homocysteine S-methyltransferase n=2 Tax=Candida... 195 2e-48 UniRef50_Q65V50 MHT1 protein n=3 Tax=Pasteurellaceae RepID=Q65V5... 195 2e-48 UniRef50_Q5KA93 Homocysteine S-methyltransferase, putative n=1 T... 193 6e-48 UniRef50_A4EKV4 Methionine synthase I n=4 Tax=Alphaproteobacteri... 193 8e-48 UniRef50_B8I637 Methylenetetrahydrofolate reductase n=2 Tax=Clos... 193 8e-48 UniRef50_B0MM61 Putative uncharacterized protein n=1 Tax=Eubacte... 192 1e-47 UniRef50_C9SAQ6 Homocysteine S-methyltransferase n=1 Tax=Vertici... 191 2e-47 UniRef50_B7G6P4 Predicted protein n=2 Tax=cellular organisms Rep... 191 4e-47 UniRef50_UPI00016C0A13 5-methyltetrahydrofolate--homocysteine me... 190 6e-47 UniRef50_B0PF81 Methylenetetrahydrofolate reductase n=1 Tax=Anae... 188 2e-46 UniRef50_A2R696 Contig An15c0240, complete genome n=9 Tax=Leotio... 188 2e-46 UniRef50_B1KCG4 Homocysteine S-methyltransferase n=52 Tax=Proteo... 188 2e-46 UniRef50_B6KB25 Homocysteine S-methyltransferase-1 n=3 Tax=Toxop... 186 6e-46 UniRef50_A0Z513 Putative uncharacterized protein n=1 Tax=marine ... 186 1e-45 UniRef50_C0EVI7 Methylenetetrahydrofolate reductase n=1 Tax=Euba... 186 1e-45 UniRef50_Q4DI99 Homocysteine S-methyltransferase, putative n=2 T... 185 1e-45 UniRef50_D2W5I3 Predicted protein (Fragment) n=2 Tax=Naegleria g... 184 4e-45 UniRef50_Q5UEY6 Putative homocysteine S-methyltransferase family... 183 8e-45 UniRef50_B0DTQ2 Predicted protein n=1 Tax=Laccaria bicolor S238N... 183 9e-45 UniRef50_A4R5G4 Putative uncharacterized protein n=1 Tax=Magnapo... 181 2e-44 UniRef50_A9QPD6 Methylenetetrahydrofolate reductase n=1 Tax=Meth... 179 1e-43 UniRef50_Q93088 Betaine--homocysteine S-methyltransferase 1 n=79... 178 2e-43 UniRef50_A4EBI1 Putative uncharacterized protein n=1 Tax=Collins... 176 6e-43 UniRef50_Q4PDM6 Putative uncharacterized protein n=1 Tax=Ustilag... 176 9e-43 UniRef50_A6G2A6 Homocysteine S-methyltransferase, putative n=1 T... 172 2e-41 UniRef50_D0NMR8 Putative uncharacterized protein n=1 Tax=Phytoph... 171 2e-41 UniRef50_Q4GZ92 Homocysteine S-methyltransferase, putative n=2 T... 166 6e-40 Sequences not found previously or not previously below threshold: UniRef50_C5D740 Methionine synthase n=8 Tax=Bacteria RepID=C5D74... 235 1e-60 UniRef50_B7GLS5 Methionine synthase I containing methyltransfera... 231 3e-59 UniRef50_A9FAG8 Methionine synthase n=91 Tax=Bacteria RepID=A9FA... 222 2e-56 UniRef50_Q1IQK2 Methionine synthase (B12-dependent) n=40 Tax=cel... 221 3e-56 UniRef50_C3YH00 Putative uncharacterized protein n=1 Tax=Branchi... 220 5e-56 UniRef50_Q0SIE4 Methionine synthase n=23 Tax=Bacteria RepID=Q0SI... 210 8e-53 UniRef50_D1BTI0 Methionine synthase n=24 Tax=Actinomycetales Rep... 199 1e-49 UniRef50_C5RGW2 Methylenetetrahydrofolate reductase n=1 Tax=Clos... 193 5e-48 UniRef50_B6BST6 Homocysteine S-methyltransferase n=4 Tax=root Re... 172 1e-41 >UniRef50_Q47690 Homocysteine S-methyltransferase n=56 Tax=Bacteria RepID=MMUM_ECOLI Length = 310 Score = 456 bits (1174), Expect = e-127, Method: Composition-based stats. Identities = 310/310 (100%), Positives = 310/310 (100%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR Sbjct: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG Sbjct: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA Sbjct: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQ 240 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQ Sbjct: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQ 240 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP Sbjct: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 Query: 301 ADIAALKARS 310 ADIAALKARS Sbjct: 301 ADIAALKARS 310 >UniRef50_O31463 Homocysteine S-methyltransferase ybgG n=13 Tax=Bacteria RepID=HMT_BACSU Length = 315 Score = 353 bits (906), Expect = 5e-96, Method: Composition-based stats. Identities = 155/307 (50%), Positives = 208/307 (67%), Gaps = 4/307 (1%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 NP++ +LD +++LDGAMATELE +GCNL DSLWSAK+L+E PELI++VH DY+ AGA Sbjct: 2 NPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEEPELIKQVHTDYFAAGAD 61 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQA---GTLLVAGS 121 CAITASYQ+T GFAARGL EA+++ LI SV +A +AR+ + + ++A S Sbjct: 62 CAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDEFWSLEENRLNRPKPIIAAS 121 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 +GPYGAYLADGSEYRG+Y S + FHRPR++AL++AGAD+LACET+P +E +A+ Sbjct: 122 IGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEAGADVLACETIPCLTEAKAIVR 181 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQH 241 LL +P AW SF+ +D H+SDGTP D + L + Q+ ALGINC L++ + ++ Sbjct: 182 LLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDEHRQIAALGINCTPLQHIPSLIEE 241 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 L T P++VYPNSGE YD +KTW+ W GARLIGGCCRT P Sbjct: 242 LKKNTSKPIIVYPNSGEQYDPETKTWNG-AACAESYGASARTWHEKGARLIGGCCRTKPE 300 Query: 302 DIAALKA 308 +I + A Sbjct: 301 NIQEIAA 307 >UniRef50_Q1WRK4 Homocysteine S-methyltransferase n=10 Tax=Lactobacillus RepID=Q1WRK4_LACS1 Length = 307 Score = 348 bits (893), Expect = 2e-94, Method: Composition-based stats. Identities = 136/296 (45%), Positives = 188/296 (63%), Gaps = 4/296 (1%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 ++LDGAM+T LE G + + LW+AK L++N EL+ E+H Y+ AGA IT +YQA Sbjct: 9 NHTVVLDGAMSTPLERLGADTNNDLWTAKALIDNEELVYEIHKMYFEAGADLIITDTYQA 68 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 F G E +++ LI K+V++A+KAR+ Y EN +AG++GPYGAYLA+GS Sbjct: 69 NVQAFEKVGYSEKEARNLIKKAVKIAQKARDDY--ENRTGKHNYIAGTIGPYGAYLANGS 126 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL-TAYPRARAW 192 EYRGDY SVE +Q FH PR+E L++A D+LA ET P E+ A+ ELL YP+ + + Sbjct: 127 EYRGDYELSVEEYQQFHLPRIEELVNAEVDILAIETQPKLDEVLAILELLKKKYPQQKVY 186 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVV 252 S+TL D + +SDGTPL + L Y QV+A+GINC+ LE AL+++ +T L+V Sbjct: 187 VSYTLSDDDTISDGTPLPRAIHALEDYSQVIAVGINCVKLELVEPALKNMKEITDKHLIV 246 Query: 253 YPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 YPNS YD SKTW + A + +P W AGAR+IGGCC T P +I A+ Sbjct: 247 YPNSSAVYDPKSKTWS-QPKTSATFEELIPNWYEAGARIIGGCCTTGPKEIKAVAD 301 >UniRef50_C4V3M8 Homocysteine S-methyltransferase n=5 Tax=Bacteria RepID=C4V3M8_9FIRM Length = 349 Score = 333 bits (854), Expect = 5e-90, Method: Composition-based stats. Identities = 151/306 (49%), Positives = 193/306 (63%), Gaps = 5/306 (1%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 N L L QD+L+LDGA+ATELEARG ++ D LWSAK L E P+L+R++HLDY RAGA Sbjct: 19 NVLEVRLAAQDVLVLDGALATELEARGFSVDDPLWSAKALFERPDLVRDIHLDYLRAGAD 78 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTL-LVAGSVG 123 +ASYQAT GF RG ++ L+ +SV LA++AR Y AE + LVA SVG Sbjct: 79 VLTSASYQATVDGFMQRGFTAEEAAELLRRSVRLAQEARGLYRAERSTGTAVPLVAASVG 138 Query: 124 PYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 PYGAYLADGSEYRGDY +A AFH R+ L A DLLACETLP E A+ L Sbjct: 139 PYGAYLADGSEYRGDYDVEEDALTAFHAQRLRILASAAPDLLACETLPCLHEACAIVRSL 198 Query: 184 TAYP-RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHL 242 A R A+FSF+ RD H+SDGT + + +L P+ A+G+NC A + + ++ + Sbjct: 199 RAEGIRIPAYFSFSCRDGAHISDGTEIAECARVLDAVPEAAAIGVNCTAPQYVSGLIRMI 258 Query: 243 HGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPAD 302 T P+VVYPNSGE+YDA ++ W E ++ AAGAR+IGGCCRTTP D Sbjct: 259 RQETDKPIVVYPNSGEYYDAAARVWRGAAED---FGARSREYAAAGARIIGGCCRTTPHD 315 Query: 303 IAALKA 308 AA+ A Sbjct: 316 TAAIAA 321 >UniRef50_C6VP70 Homocysteine methyltransferase n=7 Tax=Bacteria RepID=C6VP70_LACPJ Length = 309 Score = 331 bits (849), Expect = 2e-89, Method: Composition-based stats. Identities = 135/297 (45%), Positives = 185/297 (62%), Gaps = 7/297 (2%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 + ++ DGAMATELE RG +LWSA ++++P+ I+ VH Y AGA+ T +YQ Sbjct: 9 NRGPVVSDGAMATELEKRGVATNSALWSATAMLDHPDAIQAVHQSYLDAGAKIMTTNTYQ 68 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A F G+ AQ++ LI ++V +A AR+A ++AGS+GPYGAYLADG Sbjct: 69 ANVPAFEQAGIAAAQARQLIQQAVTIAHTARDASHV-----TDAVIAGSIGPYGAYLADG 123 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL-TAYPRARA 191 SEY G Y + A+Q FHR R+ ++ AG D+LA ET+P E++AL +L+ T +P+ Sbjct: 124 SEYTGAYQLTPSAYQDFHRERLALIMAAGVDVLALETMPRLDEVQALVQLITTTWPQQPY 183 Query: 192 WFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLV 251 W SF+++D + L DGT L +A P VVA+G+NC LEN AL L +PL+ Sbjct: 184 WVSFSIKDPQTLCDGTSLAAAAKWVAAQPNVVAVGVNCTTLENIAPALTTLKAAVAVPLI 243 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 VYPNSG+ YD V+KTW Q A ++PQW AAGAR+IGGCCRTTP DIA + Sbjct: 244 VYPNSGDQYDPVTKTWQATHL-SHQFASFVPQWLAAGARIIGGCCRTTPKDIATVAR 299 >UniRef50_Q0BQM8 Homocysteine S-methyltransferase n=1 Tax=Granulibacter bethesdensis CGDNIH1 RepID=Q0BQM8_GRABC Length = 313 Score = 324 bits (832), Expect = 2e-87, Method: Composition-based stats. Identities = 136/307 (44%), Positives = 179/307 (58%), Gaps = 9/307 (2%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 + +L + LLLDGA+ATELE G +L D LWS ++L++NP I VH Y AGA C Sbjct: 5 ISSLFRQARPLLLDGALATELERAGYHLDDPLWSGRLLLDNPAAIAAVHRAYLEAGADCI 64 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTL-----LVAGS 121 TASYQ + G RGL ++ +++ + LA R+ A P A LVAGS Sbjct: 65 ETASYQLSLPGLQRRGLSRGRAMSVLADAARLACSVRDDVWAGLPAAQRRNRIRPLVAGS 124 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 +GPYGA ADGSEY G Y S + AFH PR+ AL GADL+ACET+P+ E A A+ Sbjct: 125 LGPYGACQADGSEYTGRYALSRSQYLAFHAPRMRALAAGGADLIACETVPHLDEALAFAD 184 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQH 241 LL A W SF++RD+ H++DGTPLR V +A P V A+GINC A ++ Sbjct: 185 LLQAL-SVPGWVSFSVRDAAHIADGTPLRLCVQAMASCPFVAAIGINCTDPVLVPALIRC 243 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 L LP++VYPN+GE +D V++ W H A+ W GAR++GGCCRT P Sbjct: 244 LRR-GGLPVIVYPNAGEPFDLVTRCWGHRR--SDDWAEQARSWLRLGARIVGGCCRTRPD 300 Query: 302 DIAALKA 308 DI AL+ Sbjct: 301 DIRALRR 307 >UniRef50_B2VXK3 Homocysteine S-methyltransferase n=2 Tax=Pleosporineae RepID=B2VXK3_PYRTR Length = 319 Score = 321 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 156/308 (50%), Positives = 209/308 (67%), Gaps = 5/308 (1%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 N L A + K L+LDGA+AT LE G +++ +LWSA +L++ P LI++ HLDYYRA A Sbjct: 8 NRLSAHIVKGSPLILDGALATYLETLGADISGALWSASILLDQPSLIKQTHLDYYRANAN 67 Query: 65 CAITASYQATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQ--AGTLLVAGS 121 AITASYQA+ G L+E ++K ++ KSVELA++AR+ Y+ E+ L +AGS Sbjct: 68 VAITASYQASIPGLVKHLQLNEKEAKDVVKKSVELAQEARDQYITESTAKVGNQLFIAGS 127 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 VGPYGA+LADGSEYRGDY E + FHR R++AL++AG D+LACET+P+ +E EA+ + Sbjct: 128 VGPYGAFLADGSEYRGDYSIPKEEMKDFHRGRIQALVEAGVDILACETIPSKAETEAIID 187 Query: 182 LL-TAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQ 240 LL T + AWF FTLRDSEH+SDGT L ++ AL QVVALG NC+ + + AAL+ Sbjct: 188 LLTTEFASTEAWFGFTLRDSEHISDGTSLAEIAALFDNVQQVVALGFNCVPDDLSVAALK 247 Query: 241 HLHGLTVLP-LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 L L LVVYPNSGE ++A ++ W + LA+ +W+ AGA LIGGCCRTT Sbjct: 248 TLKPLVKRGTLVVYPNSGEQWNAQAREWEGKRTEGSSLAEKTREWRDAGAGLIGGCCRTT 307 Query: 300 PADIAALK 307 P DI +K Sbjct: 308 PKDIGVMK 315 >UniRef50_Q8LAX0 Homocysteine S-methyltransferase 3 n=52 Tax=Embryophyta RepID=HMT3_ARATH Length = 347 Score = 321 bits (822), Expect = 3e-86, Method: Composition-based stats. Identities = 137/307 (44%), Positives = 178/307 (57%), Gaps = 16/307 (5%) Query: 18 LLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPAG 77 ++DG ATEL+ G ++ D LWSAK L+ +P L+ +VHLDY +GA ITASYQAT G Sbjct: 25 VVDGGFATELQRHGADINDPLWSAKCLITSPHLVTKVHLDYLESGANIIITASYQATIQG 84 Query: 78 FAARGLDEAQSKALIGKSVELARKAREAY------------LAENPQAGTLLVAGSVGPY 125 F A+GL +++ L+ +SVE+ +ARE + A +LVA SVG Y Sbjct: 85 FVAKGLSVGEAENLLRRSVEITYEAREIFYNRCTKGSWDFAYAGKASRRPILVAASVGSY 144 Query: 126 GAYLADGSEYRGDYHCSV--EAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 GAYLADGSEY G Y SV E + FHR RV+ L +GADL+A ET+PN E EA A+LL Sbjct: 145 GAYLADGSEYSGIYGDSVSKETLKDFHRRRVQILAKSGADLIAFETIPNKLEAEAYADLL 204 Query: 184 TAYP-RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHL 242 AWFSFT +D + G + + + VVA+GINC A A + L Sbjct: 205 EEEDIDIPAWFSFTSKDGVSVPRGDSVVECAKVADSCKNVVAIGINCTAPRYIHALIISL 264 Query: 243 HGLTVLPLVVYPNSGEHYDAVSKTW-HHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 +T P+VVYPNSGE YD ++K W GE Y+ +W+ AGA L GGCCRTTP Sbjct: 265 RQMTRKPIVVYPNSGEVYDGLNKKWIKSEGESEEDFVSYVSKWRDAGASLFGGCCRTTPN 324 Query: 302 DIAALKA 308 I A+ Sbjct: 325 TIRAIAK 331 >UniRef50_D1HYS9 Whole genome shotgun sequence of line PN40024, scaffold_20.assembly12x (Fragment) n=6 Tax=rosids RepID=D1HYS9_VITVI Length = 330 Score = 320 bits (821), Expect = 3e-86, Method: Composition-based stats. Identities = 136/298 (45%), Positives = 180/298 (60%), Gaps = 9/298 (3%) Query: 18 LLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPAG 77 ++DG +ATELE G +L D LWSA L+ +P+LIR VHLDY AGA ITASYQAT G Sbjct: 24 VIDGGLATELERHGADLNDPLWSATCLIHSPDLIRRVHLDYLEAGASIIITASYQATIQG 83 Query: 78 FAARGLDEAQSKALIGKSVELARKAREAYLAENPQA-----GTLLVAGSVGPYGAYLADG 132 F A+GL +++ L+ +SVE+A +AR+ Y + +LVA SVG YGAYLADG Sbjct: 84 FEAKGLSREEAEVLLRRSVEIACEARDIYHERCAKGTCLEQRPILVAASVGSYGAYLADG 143 Query: 133 SEYRGDYH--CSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYP-RA 189 SEY G Y ++E + FHR RV+ L ++GADL+A ET+PN E +A AELL + Sbjct: 144 SEYSGHYGAAVTLETLKDFHRRRVQVLAESGADLIAFETIPNKLEAKAYAELLDEENIKI 203 Query: 190 RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLP 249 AWFSFT D ++ G L + ++ QVVA+GINC + + +T P Sbjct: 204 PAWFSFTSLDGINVVSGDSLIECASIADSCKQVVAVGINCTPPRFIHGLILLIQKVTTKP 263 Query: 250 LVVYPNSGEHYDAVSKTW-HHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 +V+YPNSGE YD V K W G Y+ +W+ AGA L GGCCRT+P I A+ Sbjct: 264 VVIYPNSGETYDGVRKEWVKSSGVQDGDFVSYVSKWREAGASLFGGCCRTSPHTIRAI 321 >UniRef50_Q4Q0C9 Homocysteine S-methyltransferase, putative n=3 Tax=Leishmania RepID=Q4Q0C9_LEIMA Length = 339 Score = 320 bits (821), Expect = 3e-86, Method: Composition-based stats. Identities = 159/302 (52%), Positives = 201/302 (66%), Gaps = 8/302 (2%) Query: 10 LLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITA 69 L D +++LDG +ATELE RGC+L D LWS KVL+E+P+ ++ V L Y RAGA+C ITA Sbjct: 24 LADPNYVVMLDGGLATELETRGCDLRDPLWSGKVLLESPQQLQNVALAYLRAGARCIITA 83 Query: 70 SYQATPAGFAARG-LDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 SYQ TP L E + A I +SV +A+ ARE +L E PQA + VAGSVGPYGAY Sbjct: 84 SYQITPQSLMEHRRLTEDAAVAAIEESVRIAQSARERHLREKPQAAPIFVAGSVGPYGAY 143 Query: 129 LADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT-AYP 187 LADGSEYRGDY S E F+ FHR R+ ALL AGAD+LA ET P+ +E+ A+ LL +P Sbjct: 144 LADGSEYRGDYVRSAEEFKEFHRLRIAALLRAGADVLAIETQPSAAEVRAIVALLQEEHP 203 Query: 188 RARAWFSFT---LRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHG 244 RAW SFT + E +SDGT D+++ L PQ+VA+G+NCI + +A L HLH Sbjct: 204 NCRAWVSFTTSRISPVEAISDGTKWADIISFLEKAPQIVAVGVNCIPMAEASAVLAHLHT 263 Query: 245 LTVLPLVVYPNSGEHYDAVSKTWHH---HGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 LT +PLVVY NSGE YDAV++TWH L +W + GARL+GGCCRT P+ Sbjct: 264 LTTMPLVVYTNSGESYDAVTRTWHPISMSDGTTLSLGALAREWASHGARLVGGCCRTGPS 323 Query: 302 DI 303 DI Sbjct: 324 DI 325 >UniRef50_C1F5Y3 Homocysteine S-methyltransferase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F5Y3_ACIC5 Length = 310 Score = 319 bits (818), Expect = 8e-86, Method: Composition-based stats. Identities = 129/292 (44%), Positives = 171/292 (58%), Gaps = 5/292 (1%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 I +LDG MATELE RG N++ LWSA VL E+PE I+ VHLDY RAG+ C T SYQ + Sbjct: 11 RIRVLDGGMATELERRGFNISGPLWSAHVLDESPEAIQAVHLDYLRAGSDCISTVSYQIS 70 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 G+A + + +SV LA +AR Y EN + + +A S+GPYGA L +G+E Sbjct: 71 AQGYAELSRPDPAFATALRRSVALAEEARARYAQENSR--PIWIAASLGPYGAALHNGAE 128 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 + G+Y + + FHR R+ L + GADL+A ET+P+ E A+ LT P AW S Sbjct: 129 FHGNYSITFDDLVEFHRARLAVLAETGADLVAFETIPSLDEARAILTALTHTPNVSAWLS 188 Query: 195 FTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYP 254 FT RD H++ G PL LL QV+ALGINC A + L T P++ YP Sbjct: 189 FTCRDEAHIAHGEPLAACAQLLDSAVQVLALGINCTAPRHVAPLLAAAQSQTRKPVIAYP 248 Query: 255 NSGEHYDAVSKTWHHHGEHCAQLADY---LPQWQAAGARLIGGCCRTTPADI 303 NSGE ++A ++ W + A++ DY QW AAGA+ IGGCCRTTP I Sbjct: 249 NSGESWNAATRAWQGRTDLAAEVKDYQTLAGQWFAAGAQAIGGCCRTTPEHI 300 >UniRef50_B3S7K9 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3S7K9_TRIAD Length = 321 Score = 317 bits (814), Expect = 2e-85, Method: Composition-based stats. Identities = 118/308 (38%), Positives = 175/308 (56%), Gaps = 15/308 (4%) Query: 14 QDILLLDGAMATELEARGCNL-ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 ++IL++DGA TEL+ G ++ AD LWSA +L+ NP++I+++H Y AGA +TA+YQ Sbjct: 3 KEILVIDGACGTELQRLGYDVDADPLWSASLLLTNPQVIKDLHTSYLNAGADIILTATYQ 62 Query: 73 ATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAE------NPQAGTLLVAGSVGPY 125 A+ G L EA + A+I +V LA +AR+ + AE N + LV GSVGP+ Sbjct: 63 ASIPGLVQYADLTEASASAVIAMAVRLAIEARDEFWAEQKACNKNVRRPKPLVVGSVGPF 122 Query: 126 GAYLADGSEYRGDY--HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 GA DGSE+ G Y ++E + +H+PR+ L+ G DL+A ET+P E AL ++L Sbjct: 123 GACQHDGSEFHGRYTDEMTIEELKQWHKPRIMELIQNGVDLIAFETIPAEKEAIALIQVL 182 Query: 184 TAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLH 243 + +AW SF +D HL+ G DV+ + Q+VA+G NC +N +Q Sbjct: 183 ETFRGVKAWLSFVCKDDLHLNHGELFADVMERFRNHNQIVAIGTNCTNPQNVDNLIQSCK 242 Query: 244 GLT--VLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 L P + YPNSGE + W +L+DY+ +W G R IGGCCRTTP+ Sbjct: 243 RLDAYDKPFIAYPNSGESWSVDR--WDPTIP-PVELSDYVQRWIKNGIRWIGGCCRTTPS 299 Query: 302 DIAALKAR 309 DI ++ + Sbjct: 300 DILKIRNK 307 >UniRef50_B1MXY2 Homocysteine S-methyltransferase n=1 Tax=Leuconostoc citreum KM20 RepID=B1MXY2_LEUCK Length = 303 Score = 316 bits (811), Expect = 4e-85, Method: Composition-based stats. Identities = 125/309 (40%), Positives = 184/309 (59%), Gaps = 11/309 (3%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M++ LL + + +LDG + +E++ + +A++LWSA L++ P L+R++H Y+ Sbjct: 1 MTK---FSELLLQGPV-ILDGGLGSEIDKQHIAVANNLWSASALIQAPNLVRDIHQSYFN 56 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGAQ AI +YQA P F GL E ++ LI +V LAR + + ++AG Sbjct: 57 AGAQIAIVDTYQAHPQTFVDSGLSENEAYELIDLAVALARD-----GLKKSEKSLGIIAG 111 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 SVGPYGAYLA+G+EY GDY S++A+QAFHR R++ L+ D+LA ET+PNF E +A+A Sbjct: 112 SVGPYGAYLANGAEYTGDYDLSIQAYQAFHRQRIKRLVHNNVDILALETMPNFKEAQAIA 171 Query: 181 ELLT-AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAAL 239 LL +P A+ SF +HL DGT L VA + Q+ A+GINC A +N A+ Sbjct: 172 LLLQNEFPEVEAYLSFATEVGDHLWDGTRLAHAVAYFNQFEQIKAIGINCTAPDNILPAI 231 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 + T +++YPN+GE Y+ +K W + E +P WQ AGA +IGGCCRT+ Sbjct: 232 MRIKPNTDKKVILYPNAGEVYNPETKRWVTNNE-PINWRRLVPLWQHAGADIIGGCCRTS 290 Query: 300 PADIAALKA 308 P DI + Sbjct: 291 PEDIREIHD 299 >UniRef50_D1BKY6 Homocysteine S-methyltransferase n=3 Tax=Veillonella RepID=D1BKY6_VEIPT Length = 341 Score = 316 bits (811), Expect = 5e-85, Method: Composition-based stats. Identities = 117/337 (34%), Positives = 179/337 (53%), Gaps = 31/337 (9%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M++ + ++ ++D L+LDGA+ TELE GC++ LWSAKVL++ P++I+++H+ Y Sbjct: 5 MAKRSAFLDIIKEKDALVLDGALGTELERYGCDIQHKLWSAKVLMDQPDIIKKIHISYLA 64 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAG------ 114 AGA ++ YQAT AGF G ++ L+ SV LA +AR +L Sbjct: 65 AGADIIQSSGYQATVAGFKGLGYGTEEAIELVKLSVRLAVQARNEFLEAKASGALTLRGI 124 Query: 115 -------------------TLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVE 155 LVA SVGPYGA+LADGSEYRG E + FH PR+ Sbjct: 125 KLGEETPEGVKYFSEGALPKPLVAASVGPYGAFLADGSEYRGYPDVQTEYLEVFHIPRLA 184 Query: 156 ALLDAGADLLACETLPNFSEIEALAELLTA---YPRARAWFSFTLRDSEHLSDGTPLRDV 212 + D+L+ ET+P+++E A+A ++ AW +F+ +D H+S G + Sbjct: 185 LFCEENPDILSFETIPSYAEAIAIARAMSDPFTSKGIPAWIAFSCKDGHHVSSGETIIKC 244 Query: 213 VALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGE 272 ++ + +GINC E + ++ + +T P+ VYPN GE YD+ +KTW+ Sbjct: 245 AQMIDKVHPITGIGINCTKPEYVESLIKDIRTVTDKPIAVYPNLGESYDSKTKTWYG--- 301 Query: 273 HCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKAR 309 A DY+ W+ AGA +IGGCCRTTP I + + Sbjct: 302 DAASFVDYVEVWRKAGAEIIGGCCRTTPEIIGDIAKK 338 >UniRef50_B9E9X6 Putative uncharacterized protein n=1 Tax=Macrococcus caseolyticus JCSC5402 RepID=B9E9X6_MACCJ Length = 295 Score = 316 bits (809), Expect = 8e-85, Method: Composition-based stats. Identities = 115/294 (39%), Positives = 176/294 (59%), Gaps = 11/294 (3%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 +QDI++LDG T +E G ++ LWS+ ++ NPE + +VH + +GA+ +T +YQ Sbjct: 8 QQDIVILDGGFGTTVEQFGYDVKHELWSSNLIQSNPEAVYKVHKAFVDSGAEIILTNTYQ 67 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A+ F G+D+A + + +VELA +A + ++AGS+GPYGA L +G Sbjct: 68 ASVQSFLNIGIDKATACTYLATAVELATRAA---------SNRTIIAGSLGPYGAMLGNG 118 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 SEY GDY + + +H+ R++ L++AG + A ET+PN EI+A+ LL YP AW Sbjct: 119 SEYTGDYEETEADYIQYHKERLDILIEAGVSVFAFETIPNIEEIKAVRTLLLDYPHIEAW 178 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVV 252 S TL+D +HLSDGTPL V+ ++ V+A G+NC ++ AA+ L L+ PL++ Sbjct: 179 ISVTLKDHDHLSDGTPLEAVIEVVNEIENVLAFGVNCTSVNVIDAAVDKLITLSDKPLIL 238 Query: 253 YPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 YPNSG YDAV K W + A L + P+W+ G ++IGGCC+ P +I L Sbjct: 239 YPNSGRQYDAVHKVWIDQED--ASLVEAAPRWKEKGVKIIGGCCQVGPGEIKEL 290 >UniRef50_A5VKC8 Homocysteine S-methyltransferase n=10 Tax=Lactobacillus RepID=A5VKC8_LACRD Length = 310 Score = 316 bits (809), Expect = 1e-84, Method: Composition-based stats. Identities = 135/295 (45%), Positives = 184/295 (62%), Gaps = 4/295 (1%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 LL+DGAM+T LE G + +SLW+A VL P L+++VH +Y++AG + AIT +YQA Sbjct: 10 KPLLIDGAMSTALEQLGADTNNSLWTASVLANQPALVKKVHQEYFKAGDRLAITDTYQAN 69 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 F G + ++ +LI ++V LA++AR+ Y E VAG++GPYGAYLA+GSE Sbjct: 70 VPAFIKNGYSKQEAHSLIQRAVVLAKEARDEYQQETGIYN--YVAGALGPYGAYLANGSE 127 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY-PRARAWF 193 Y G YH S +Q FHRPR+ +L G D++A ET P E+ A +L+ P + Sbjct: 128 YSGAYHLSTIEYQQFHRPRLTDILTVGVDVIAIETQPRLDEVLAELDLVKELAPDTLCYV 187 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVY 253 SF+L+DS HL DGTPL +A Y V A+G+NCI LE TAA++ +H +T P++ Y Sbjct: 188 SFSLKDSTHLPDGTPLAVAARTVAKYTNVFAVGVNCIPLEEVTAAIETVHQVTEKPVIAY 247 Query: 254 PNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 PNS YD +KTW + L DYLPQW AAG ++GGCC TTP DIAAL Sbjct: 248 PNSSATYDPTTKTWS-YPHGRRGLVDYLPQWIAAGLIIVGGCCTTTPQDIAALHE 301 >UniRef50_D2RKX3 Homocysteine S-methyltransferase n=2 Tax=Acidaminococcus RepID=D2RKX3_ACIFE Length = 317 Score = 315 bits (808), Expect = 1e-84, Method: Composition-based stats. Identities = 133/311 (42%), Positives = 184/311 (59%), Gaps = 8/311 (2%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 L+ +LD+ IL++DG+M T LE G +L +SLW+A+VL PEL+++VHLDY+RAG Sbjct: 1 MRQTLKNILDQNKILVIDGSMGTALENLGADLNNSLWTARVLANRPELVKQVHLDYFRAG 60 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAG----TLLV 118 A IT SYQA+ G A G E +++ LI +SV + ++AR+ + +A L + Sbjct: 61 ADAGITCSYQASIPGLVANGFTEQEAEELITRSVTIFQEARQEWWDREGKAAGRAWPLCL 120 Query: 119 AGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 AG VGPYGAYLADGSEYRG Y S E + FHR R E L AGAD+L ET P+ E Sbjct: 121 AG-VGPYGAYLADGSEYRGHYGVSREDLEKFHRRRAELLWQAGADVLLFETQPSLEEALV 179 Query: 179 LAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVA-LLAGYPQVVALGINCIALENTTA 237 + A W SF+ RD H+ +GTP+R+ A ++ +P+V ALG+NC E + Sbjct: 180 EVSIAKDLGAA-FWVSFSCRDGLHICEGTPIREAAAEVVRQFPEVEALGVNCTKPEYLVS 238 Query: 238 ALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCR 297 + L + P+ VYPNSGE YD V+KTWH G + DY ++ AGA +GGCC Sbjct: 239 LIGELKTASDRPIFVYPNSGEEYDPVTKTWHGVGTD-RKFGDYALEYMKAGAVAVGGCCT 297 Query: 298 TTPADIAALKA 308 T + + A Sbjct: 298 TVADHVRQVAA 308 >UniRef50_C3ZEE1 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae RepID=C3ZEE1_BRAFL Length = 315 Score = 310 bits (794), Expect = 5e-83, Method: Composition-based stats. Identities = 120/303 (39%), Positives = 170/303 (56%), Gaps = 14/303 (4%) Query: 18 LLDGAMATELEARGCNLA-DSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 +LDG +ATEL+ G ++ D LWSA++L NP I++VH + AG+ ITA+YQA+ Sbjct: 5 VLDGGLATELDFAGFDINNDPLWSARLLATNPAAIKQVHKSFLSAGSDVIITATYQASVP 64 Query: 77 GFAAR-GLDEAQSKALIGKSVELARKAREAYLAEN-----PQAGTLLVAGSVGPYGAYLA 130 GF G+ ++ L+ V +A++A + E P L AGSVGPYGA L Sbjct: 65 GFQEYLGVSVEEAHKLMDHGVRIAKQACLEFCKEQDKGDFPGRRNPLAAGSVGPYGACLH 124 Query: 131 DGSEYRGDY--HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPR 188 D SEY G+Y S+E Q +HRPR+ L+ +GAD++A ET+P E AL +LL +P Sbjct: 125 DASEYTGEYVDSMSIEELQRWHRPRLGQLITSGADMVAIETIPAVKEAAALVQLLREFPN 184 Query: 189 ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVL 248 RAW +F+ +D H G + +A + PQV A G NC E+ LQ L Sbjct: 185 TRAWVTFSCKDGLHTCHGESFPEAIAAVLKSPQVFAAGANCCMPEHVAPLLQKARELCKD 244 Query: 249 P---LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAA 305 P + YPNSGE + A + WH + C L+ ++P+W GAR IGGCCRT P DI Sbjct: 245 PAKFFIAYPNSGEKWAAGTG-WHGKAD-CRPLSTFVPEWLDHGARWIGGCCRTRPDDIKD 302 Query: 306 LKA 308 +++ Sbjct: 303 IRS 305 >UniRef50_B0NWZ7 Putative uncharacterized protein n=1 Tax=Clostridium sp. SS2/1 RepID=B0NWZ7_9CLOT Length = 319 Score = 308 bits (790), Expect = 2e-82, Method: Composition-based stats. Identities = 116/312 (37%), Positives = 176/312 (56%), Gaps = 7/312 (2%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 N + ++ + I+++DG+M+T LE RG +L LW+AK+L E PELI++VH +Y++AG Sbjct: 2 MKNSIENIIKENKIMVIDGSMSTPLENRGVSLNSKLWTAKILAEQPELIKQVHKNYFKAG 61 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTL---LVA 119 A C IT SYQA+ G G +++ LI +V++ +AR+ + E + L Sbjct: 62 ADCGITCSYQASIPGLMENGYTLEEAENLIRSAVKIFCEARDEWWEEEGREARRAWPLCL 121 Query: 120 GSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEAL 179 G+ GPYGAYLADGSEYRG+Y + E + FH+ RVE L +AGAD++ ET+P+ E + Sbjct: 122 GAAGPYGAYLADGSEYRGNYGITDEQLKEFHKRRVELLHEAGADIILFETVPSLKEAKVE 181 Query: 180 AELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLA-GYPQVVALGINCIALENTTAA 238 AE+ Y W SF+ + +GTP+ + A GYP + +G+NC E T Sbjct: 182 AEIAEEYGY-DYWISFSCLSENIICEGTPIAECATTFAKGYPHLKMIGVNCTKPEYITGL 240 Query: 239 LQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRT 298 + + +P+ VYPNSGE YDAV K W + Y + +GA +GGCC T Sbjct: 241 IHKIKENCDIPIGVYPNSGEEYDAVKKVWFGK-QSALSFEQYAYNYMKSGASAVGGCCTT 299 Query: 299 TPADIAA-LKAR 309 + ++A+ Sbjct: 300 VAKHVEEVVRAK 311 >UniRef50_A8KB71 Zgc:171603 protein n=4 Tax=Clupeocephala RepID=A8KB71_DANRE Length = 311 Score = 308 bits (789), Expect = 2e-82, Method: Composition-based stats. Identities = 120/301 (39%), Positives = 176/301 (58%), Gaps = 11/301 (3%) Query: 15 DILLLDGAMATELEARGCNL-ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 +LDG +ATELEA G L D LWSA+VL +P+ I++VH Y ++G+ TA+YQA Sbjct: 8 SPFILDGGLATELEASGFLLQGDPLWSARVLHTDPQAIKDVHYRYLQSGSDVITTATYQA 67 Query: 74 TPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENP--QAGTLLVAGSVGPYGAYLA 130 + GF G+ +++ ++ +V+LA++ +++++P LVAGSVGPYG++L Sbjct: 68 SIEGFVKYLGVQPEEAQHMMMSAVQLAKETVSEFISQSPMSDRREPLVAGSVGPYGSFLH 127 Query: 131 DGSEYRGDYHC--SVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPR 188 DGSEY G Y +VE + +HRP+++ L+ AGADL+A ET+P E EAL E+L +P Sbjct: 128 DGSEYTGAYEDKMTVEELKDWHRPQIQCLVKAGADLVAMETIPGLKEAEALVEVLKEFPE 187 Query: 189 ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHL--HGLT 246 +AW SF+ +D+ +S G + V + Q+VA+G+NC L+ H Sbjct: 188 TKAWLSFSCKDNNSISSGRRFSEAVEMACRSTQLVAVGVNCCPAPLVKPLLESAKSHKRA 247 Query: 247 VLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 L VVYPNSGE +D + E A+ +W+A GA IGGCCR PADI L Sbjct: 248 DLSWVVYPNSGEGWDVTTG---WKTEMRTSFANLSLEWKAQGALWIGGCCRVRPADITEL 304 Query: 307 K 307 K Sbjct: 305 K 305 >UniRef50_Q5M5A7 Homocysteine S-methyltransferase (S-methylmethionine) n=21 Tax=Streptococcus RepID=Q5M5A7_STRT2 Length = 322 Score = 307 bits (787), Expect = 3e-82, Method: Composition-based stats. Identities = 130/308 (42%), Positives = 183/308 (59%), Gaps = 9/308 (2%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 + L+ L+L GA+ TE+EA G +++ LWSAK L+E E+I+E+H Y AGA Sbjct: 10 FKDYLENNSPLILHGALGTEMEALGYDISGKLWSAKYLLEKSEVIQELHETYVAAGADLI 69 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLA-----ENPQAGTLLVAGS 121 T+SYQAT G GL E ++ +I +V LA+ AR+ E + L++G Sbjct: 70 TTSSYQATLPGLVEAGLTEKAAEQIIALTVRLAKAARDKVWGALDETEKAKRPYPLISGD 129 Query: 122 VGPYGAYLADGSEYRGDYH-CSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 VGPY AYLA+GSEY GDY +++ + FHRPR++ LLD G DLLA ET+PN E +AL Sbjct: 130 VGPYAAYLANGSEYSGDYGQITIKELKDFHRPRIQILLDQGVDLLALETIPNRLETQALI 189 Query: 181 ELLT-AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAAL 239 ELL +P A A+ SFT++ + +SDGT L ++ L++ Q++A+GINC + AL Sbjct: 190 ELLAEEFPEAEAYMSFTVQIPDAISDGTSLAEMAKLVSQSNQILAVGINCSSPLLYNQAL 249 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAA-GARLIGGCCRT 298 L L+ YPNSGE YD S+TW + L ++ W A G +++GGCCRT Sbjct: 250 AFLKN-AGKALITYPNSGEVYDGDSQTWKPKDKDALTLVEHSKYWHAHFGVKILGGCCRT 308 Query: 299 TPADIAAL 306 P DI AL Sbjct: 309 RPNDIKAL 316 >UniRef50_UPI0000DB6B54 PREDICTED: similar to CG10621-PA n=3 Tax=Apocrita RepID=UPI0000DB6B54 Length = 320 Score = 302 bits (773), Expect = 1e-80, Method: Composition-based stats. Identities = 115/313 (36%), Positives = 176/313 (56%), Gaps = 18/313 (5%) Query: 14 QDILLLDGAMATELEARGCNL--ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 Q++++LDG +T+L + D LW+A+ LV NP I HLD+ +AGA +T +Y Sbjct: 2 QEVMVLDGGFSTQLATHVDDTIDGDPLWTARFLVTNPNAIISTHLDFLKAGADIILTNTY 61 Query: 72 QATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQAGTL-----LVAGSVGPY 125 QA+ GF+ + E +S + K+V+ A++A Y + G + L+AGS+GPY Sbjct: 62 QASIDGFSKYMNITEEESLDIFSKAVDYAKEAVNLYKKDIENKGNVINANPLIAGSIGPY 121 Query: 126 GAYLADGSEYRGDY--HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 GA L D SEY G Y + + E +HRPR++ L+D G +LA ET+P E EAL +LL Sbjct: 122 GACLHDASEYSGKYCSNVTEEFLINWHRPRIQKLIDNGVHILAIETIPCKQEAEALIKLL 181 Query: 184 TAYPRARAWFSFT-LRDSEHLSDGTPLRDVVA--LLAGYP-QVVALGINCIALENTTAAL 239 +P ++AW SF+ D + ++DGT + + P Q++A+G+NC A +N T L Sbjct: 182 KEFPNSKAWLSFSCCNDGKSIADGTNFQQIAMQCYREALPKQILAIGVNCTAPQNVTKLL 241 Query: 240 QHLHGLTV---LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCC 296 + ++ +PLVVYPNSGE Y + W E L +++ +W G R IGGCC Sbjct: 242 KGINENNKQEFVPLVVYPNSGEKY-TIENGWTIKDEEECSLHEFIYEWLTLGVRYIGGCC 300 Query: 297 RTTPADIAALKAR 309 RT DI +++ Sbjct: 301 RTNATDIKKIRSE 313 >UniRef50_B0RCV4 Homocysteine s-methyltransferase n=15 Tax=Actinomycetales RepID=B0RCV4_CLAMS Length = 301 Score = 301 bits (772), Expect = 2e-80, Method: Composition-based stats. Identities = 128/310 (41%), Positives = 176/310 (56%), Gaps = 14/310 (4%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M++ PL L+LDG + T LEARG +L+D LWSA+VL + P+ +R H +Y+R Sbjct: 1 MTRPRPL-----PNRPLVLDGGLGTLLEARGHDLSDPLWSARVLADEPDAVRAAHAEYFR 55 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENP--QAGTLLV 118 AGA AITASYQ FAARGL A+++ L+ SV LA +AR+ ++ + Sbjct: 56 AGADVAITASYQVGFEAFAARGLSAAETEELLRASVRLAAEARDEVAQDDAPGAGRDRWI 115 Query: 119 AGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 A SVGPYGA L DGSEY + + +H PR L D+GADLLACET+P+ E A Sbjct: 116 AASVGPYGATLGDGSEYAASSGLTRAELRRWHAPRFAVLADSGADLLACETVPSLDEGRA 175 Query: 179 LAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAA 238 L +L A AW +FT+ L G P+ + L G ++VA+GINC E AA Sbjct: 176 LVDLARG-SGASAWLAFTV-QGGRLRSGEPMAEGFRLANGADEIVAVGINCAHPEEVPAA 233 Query: 239 LQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRT 298 + G+T P+ VYPNSGE +DAV++ W + + W AAGA ++GGCCR Sbjct: 234 IAAARGVTDRPVAVYPNSGERWDAVARAWGGDPALPS-----VDAWIAAGASIVGGCCRV 288 Query: 299 TPADIAALKA 308 P +I ++ Sbjct: 289 GPDEIRRMRD 298 >UniRef50_A8YVC8 Homocysteine S-methyltransferase n=2 Tax=Lactobacillus helveticus RepID=A8YVC8_LACH4 Length = 331 Score = 301 bits (772), Expect = 2e-80, Method: Composition-based stats. Identities = 118/291 (40%), Positives = 161/291 (55%), Gaps = 4/291 (1%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 ++LDGAM+ ELE +G + LW+A L+ + I + H DY+ AGA+ IT +YQA Sbjct: 42 IVLDGAMSDELERQGVKTNNKLWTATALINELDKIYQAHWDYFTAGAELVITDTYQANVQ 101 Query: 77 GFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYR 136 F G E +++ I +V++A+KAR+ Y E VAG+VG Y AYLADG+EYR Sbjct: 102 AFTQAGYSEQEAEKFIRDAVKVAKKARDDY--EQKTGKHNYVAGTVGSYSAYLADGNEYR 159 Query: 137 GDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA-YPRARAWFSF 195 GDY S + AFH PR+ +L DL+A ET P E A+ L + SF Sbjct: 160 GDYELSELEYLAFHLPRLRQILAEKPDLIALETQPKLDEPLAVLNWLKENASDYPVYVSF 219 Query: 196 TLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYPN 255 TL+D+ H+SDGT L V+ + + QV A+GINCI+ + AL+ + T PLV+YPN Sbjct: 220 TLKDATHISDGTTLEQAVSAVDKFEQVFAIGINCISPDLVAPALKEIGKYTFKPLVLYPN 279 Query: 256 SGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 G YD K W E +W GARLIGGCC T P +I + Sbjct: 280 LGASYDPKIKQWREFKEKF-DFNKLTKKWYQEGARLIGGCCTTGPTEIKQM 329 >UniRef50_Q4S116 Chromosome 1 SCAF14770, whole genome shotgun sequence n=5 Tax=Euteleostomi RepID=Q4S116_TETNG Length = 372 Score = 301 bits (770), Expect = 3e-80, Method: Composition-based stats. Identities = 129/340 (37%), Positives = 180/340 (52%), Gaps = 33/340 (9%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNL-ADSLWSAKVLVENPELIREVHLDYY 59 M + L L +LDG +AT+LEA+G +L D LWSA++L NP+ IR+ H + Sbjct: 1 MESSPRLNRYLCDDGPFILDGGLATDLEAQGVHLQGDPLWSARLLYTNPQAIRDAHCRFL 60 Query: 60 RAGAQCAITASYQATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQAGTL-- 116 +GA TA+YQA+ GF + +K LI V+LA++A E+++ T+ Sbjct: 61 LSGADVISTATYQASVEGFMDHLNVSSEGAKELIMSGVQLAKEAVESFVPGTNPNTTVQS 120 Query: 117 ------------------------LVAGSVGPYGAYLADGSEYRGDYH--CSVEAFQAFH 150 LVAGS+GPYGA+L +GSEY GDY SV+ +A+H Sbjct: 121 GEGKVNSEGSEGLAGQCSSGRRCPLVAGSLGPYGAFLHNGSEYTGDYAEKMSVQELKAWH 180 Query: 151 RPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSFTLRDSEHLSDGTPLR 210 RP+VE L A AD+LA ET+P+ E EAL ELL +P +AW S + +D + LSDG+ R Sbjct: 181 RPQVECLAAAEADVLAFETIPSIKEAEALVELLKEFPNTKAWLSLSCKDVKRLSDGSLFR 240 Query: 211 DVVALLAGYPQVVALGINCIALENTTAALQHLHGL--TVLPLVVYPNSGEHYDAVSKTWH 268 D V + Q++A+G+NC E L L + VVYPNSGE +D + W Sbjct: 241 DAVQIANRSEQLIAVGVNCCPPELVEPLLDSARTLLSPEISWVVYPNSGESWDPE-QGWC 299 Query: 269 HHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 L + W GA LIGGCCR +PA +A L+ Sbjct: 300 TSEAALPALLEMSGTWVKQGAALIGGCCRISPAHVAKLRR 339 >UniRef50_Q5PNQ3 Novel protein containing a homocysteine S-methyltransferase domain (Fragment) n=4 Tax=Euteleostomi RepID=Q5PNQ3_DANRE Length = 318 Score = 301 bits (770), Expect = 3e-80, Method: Composition-based stats. Identities = 119/305 (39%), Positives = 176/305 (57%), Gaps = 15/305 (4%) Query: 15 DILLLDGAMATELEARGCNL-ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 +LDG +ATELEA G L D LWSA+VL +P+ I++VH Y ++G+ TA+YQA Sbjct: 11 SPFILDGGLATELEASGFQLQGDPLWSARVLHTDPQAIKDVHYRYLQSGSDVITTATYQA 70 Query: 74 TPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENP--QAGTLLVAGSVGPYGAYLA 130 + GF G+ +++ ++ +V+LA++ +++++P LVAGSVGPYG++L Sbjct: 71 SIEGFVKYLGVQPEEAQHMMMSAVQLAKETVSEFISQSPMSDRREPLVAGSVGPYGSFLH 130 Query: 131 DGSEYRGDYHC--SVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPR 188 DGSEY G Y +VE + +HRP+++ L+ AGADL+A ET+P E EAL ++L +P Sbjct: 131 DGSEYTGAYEDKMTVEELKDWHRPQIQCLVKAGADLVAMETIPGLKEAEALVKVLKEFPE 190 Query: 189 ARAWFSFT----LRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHL-- 242 +AW SF+ +D+ +S G + V + Q+VA+G+NC L+ Sbjct: 191 TKAWLSFSSINLFQDNNSISSGRRFSEAVEMACRSTQLVAVGVNCCPALLVKPLLESAKS 250 Query: 243 HGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPAD 302 H L VVYPNSGE +D + E A+ +W+A GA IGGCCR PAD Sbjct: 251 HKRADLSWVVYPNSGEGWDVTTG---WKTEMRTSFANLSLEWKAQGALWIGGCCRVRPAD 307 Query: 303 IAALK 307 I LK Sbjct: 308 ITELK 312 >UniRef50_Q1GBT8 Homocysteine S-methyltransferase n=2 Tax=Lactobacillus delbrueckii subsp. bulgaricus RepID=Q1GBT8_LACDA Length = 310 Score = 295 bits (757), Expect = 9e-79, Method: Composition-based stats. Identities = 139/303 (45%), Positives = 181/303 (59%), Gaps = 6/303 (1%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 L LL + + LDG+M+T LEA G + LW+AK L +NP+L+ VH +Y++AGA+ Sbjct: 4 LPTLLAQGPVT-LDGSMSTPLEAWGEDTNSDLWTAKALADNPDLVYRVHQEYFKAGARVT 62 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 IT SYQA+ F GL E ++ALI +S +A KAR+ + E VAGSVGPYG Sbjct: 63 ITDSYQASLPAFMKHGLSEDAARALIRESAAVAIKARDDF--EKETGIHNFVAGSVGPYG 120 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA- 185 AYLADGSEYRGDY S E + FH PR+E L+ G D LA ET P SE+ A+ + L A Sbjct: 121 AYLADGSEYRGDYALSHEEYVDFHAPRIEELVAGGVDCLAVETQPKLSEVRAILDYLKAK 180 Query: 186 YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL 245 YP + SF+L+D +S+G PL + V ++ Y QV A G NC L T +++L Sbjct: 181 YPDLPVYVSFSLKDPATISEGLPLTEAVEEVSAYAQVFAAGANCFKLAWTVDVVKNLRA- 239 Query: 246 TVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAA 305 + LP+VVYPNSG YD K W + A W AAGA+L+GGCC T P DIA Sbjct: 240 SKLPIVVYPNSGAEYDPSVKKW-VYPPEAADFGQAGAAWLAAGAKLVGGCCTTMPEDIAG 298 Query: 306 LKA 308 L A Sbjct: 299 LAA 301 >UniRef50_UPI000050FD2A homocysteine methyltransferase n=1 Tax=Brevibacterium linens BL2 RepID=UPI000050FD2A Length = 308 Score = 294 bits (753), Expect = 3e-78, Method: Composition-based stats. Identities = 150/316 (47%), Positives = 187/316 (59%), Gaps = 21/316 (6%) Query: 1 MSQN--NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDY 58 MSQ + L+A + D L++DG + T LE+RG +L+ LWSA +L ++P+ + EVH D+ Sbjct: 1 MSQTFIHLLQAAVRSGDPLVIDGGLGTALESRGIDLSHELWSAALLRDSPDTLAEVHADF 60 Query: 59 YRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLV 118 RAGAQ TASYQATP GF + + LI +SVE+A A G LV Sbjct: 61 IRAGAQIVTTASYQATPLGFERASIPAEEGLRLIARSVEIAAGA-----------GDALV 109 Query: 119 AGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 AGSVGPYGA L +G+EY GDYH S E F AFHRPR+EAL++AGADLLA ET P+ SEI Sbjct: 110 AGSVGPYGAALGNGAEYTGDYHLSDEEFAAFHRPRIEALVNAGADLLAIETQPSLSEITV 169 Query: 179 LAELLTAYPRARAWFSFTLRDSEHLSDG------TPLRDVVALLAGYPQVVALGINCIAL 232 LA L Y AW S TL D L+DG TPL D+ +A + A+G+NC+ Sbjct: 170 LAGLADEY-GIPAWLSVTLADQGDLADGSHMADRTPLSDLAEAVADSRMIRAVGVNCVRP 228 Query: 233 ENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLI 292 AL L T LPL+ YPNSGE YDA + W + P W +AG R+I Sbjct: 229 SLVAPALAALASATDLPLIAYPNSGETYDAATMEWREDSAFDTSPSTLAP-WVSAGVRII 287 Query: 293 GGCCRTTPADIAALKA 308 GGCCRTTPADIA L Sbjct: 288 GGCCRTTPADIAGLAD 303 >UniRef50_Q2F5Q8 Homocysteine S-methyltransferase n=3 Tax=Endopterygota RepID=Q2F5Q8_BOMMO Length = 325 Score = 294 bits (752), Expect = 3e-78, Method: Composition-based stats. Identities = 113/310 (36%), Positives = 170/310 (54%), Gaps = 15/310 (4%) Query: 14 QDILLLDGAMATELEARGCNLAD--SLWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 + + +LDG +T+L + AD L SA+ L +P+ + HLD+ RAG+ T +Y Sbjct: 9 KTVFVLDGGFSTQLTCHAGHTADGDPLGSARFLKTHPQDVINTHLDFLRAGSDIIETNTY 68 Query: 72 QATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAE----NPQAGTLLVAGSVGPYG 126 QA+ G L +S LI +VE AR AR+ YL E N L+AGSVGPYG Sbjct: 69 QASVDGLVKHLNLTVEESYELIKSAVEFARTARDLYLQECQESNLSGRKPLIAGSVGPYG 128 Query: 127 AYLADGSEYRGDY--HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 AYL D SEY G+Y + + E + +HR R++AL++AG D+LA ET+P E EAL E+L Sbjct: 129 AYLHDTSEYTGNYADNTTKETIKNWHRTRIQALVEAGVDILAFETIPCQKEAEALVEILK 188 Query: 185 AYPRARAWFSFTLRDSEHLSDGTPLRDVVALL--AGYPQVVALGINCIALENTTAALQHL 242 YP +AW SF+ ++ L+ G ++V + Q++A+G+N + + T + + Sbjct: 189 EYPNMKAWLSFSCKNETSLAHGENFQNVAKKCWKSNPDQLIAIGVNGCSPKIVTELFKDI 248 Query: 243 H--GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 + T + + YPNSGE YD K + C L + + +W G R IGGCCRT Sbjct: 249 NNDQETSIQYITYPNSGETYD--HKLGWTESDKCESLHNLVAEWLDLGVRYIGGCCRTND 306 Query: 301 ADIAALKARS 310 DI+ ++ + Sbjct: 307 VDISRIRIET 316 >UniRef50_A6G853 Homocysteine methyltransferase n=3 Tax=Bacteria RepID=A6G853_9DELT Length = 325 Score = 293 bits (751), Expect = 4e-78, Method: Composition-based stats. Identities = 146/313 (46%), Positives = 184/313 (58%), Gaps = 18/313 (5%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 + L LL ++ +LDG +AT LEA GC+L D LWSA++L+++PE +R VH + AGA Sbjct: 9 DALDRLLAREPFAVLDGGLATSLEACGCDLDDPLWSARLLLDDPEALRTVHRRWRDAGAD 68 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP 124 TASYQA+ G A+GL EA++KAL+ +SV L R A + A P L+A SVG Sbjct: 69 ILATASYQASLPGLRAKGLSEARAKALLRESVTLTRAAADEANAPRP-----LIAASVGS 123 Query: 125 YGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 YGAYLADGSEYRG Y SVEA FHRPR+ L AG DL+A ET P+ E+ ALAELLT Sbjct: 124 YGAYLADGSEYRGGYGLSVEALADFHRPRLLELAAAGPDLIAFETFPDAVELAALAELLT 183 Query: 185 AYPR------ARAWFSFTLRDSE-----HLSDGTPLRDVVALLAGYPQVVALGINCIALE 233 RAW S +L L+DGTPL +A L +P+V ALG+NC+ Sbjct: 184 ELLTELGDTLPRAWISASLSPPGPDRSVRLADGTPLTKALAPLTDHPKVAALGVNCVGPR 243 Query: 234 NTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIG 293 AL+ L T PLV YPNSGE + + + W + A +W GARLIG Sbjct: 244 EVAPALEVLAACTDRPLVAYPNSGERW--IDRGWSGAALEPNKFAALAERWFELGARLIG 301 Query: 294 GCCRTTPADIAAL 306 GCCRT A I AL Sbjct: 302 GCCRTNYAHIQAL 314 >UniRef50_C4R8J7 S-adenosylmethionine-homocysteine methyltransferase n=1 Tax=Pichia pastoris GS115 RepID=C4R8J7_PICPG Length = 321 Score = 290 bits (742), Expect = 5e-77, Method: Composition-based stats. Identities = 109/320 (34%), Positives = 166/320 (51%), Gaps = 20/320 (6%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M+ + + L ++ +LDGA+ TELE G ++ LWS K L +PE I ++H Y + Sbjct: 1 MTPITKMDSWLKQKRCRVLDGALGTELEKLGIDIKSRLWSGKALFYSPETITQIHSSYIQ 60 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGA+ +T +YQ + G G+D+ ++V+LA+ A + EN + G Sbjct: 61 AGAELILTCTYQLSDQGLKDLGIDDPDVYD---RAVKLAKDAVDQNEGEN----KAKIVG 113 Query: 121 SVGPYGAYLADGSEYRGDYH-CSVEAFQAFHRPRVEALL-DAGADLLACETLPNFSEIEA 178 S+G YGAYL+ G EY G+Y S + FHR R+++LL + DL+ ET+PN E E Sbjct: 114 SIGSYGAYLSGGEEYTGEYGAISKSELEEFHRVRLQSLLTNPDVDLIGFETIPNILEAET 173 Query: 179 LAELLTAYP-----RARAWFSFTLRDSEH---LSDGTPLRDVVALLAGY--PQVVALGIN 228 L L A + SF R+ + ++DGT + +V L+ ++ A+G N Sbjct: 174 LVVLFNALATSLNVDKGYYMSFNCREESNQSVIADGTSIPEVSDRLSKLDVSRMYAIGTN 233 Query: 229 CIALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG 288 C ++ A++ T LPL+VYPNSGE YD K W GE ++ D + W Sbjct: 234 CCSISTANGAVELFSKHTNLPLIVYPNSGERYDKTEKKWLP-GECDQKITDIVVNWLQLN 292 Query: 289 ARLIGGCCRTTPADIAALKA 308 ++IGGCCRT P I L+ Sbjct: 293 VKIIGGCCRTNPHFIRQLRD 312 >UniRef50_B0K7W0 Homocysteine S-methyltransferase n=13 Tax=Firmicutes RepID=B0K7W0_THEP3 Length = 807 Score = 288 bits (737), Expect = 2e-76, Method: Composition-based stats. Identities = 71/296 (23%), Positives = 129/296 (43%), Gaps = 23/296 (7%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 +++ DGAM T+L+ RG + + + +PE++ ++H Y AGA T ++ A Sbjct: 10 NRVIVFDGAMGTQLQERGLKTGE--CPEYMNITHPEVVFDIHRSYIEAGADVIETNTFGA 67 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 A GL E + ++ ++V++A++A + VA S+GP G L Sbjct: 68 NRIKLAKYGL-ENEVFNIVTQAVKIAKEA----------SKDKPVALSIGPIGELLTPYG 116 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWF 193 + D + V A AGAD++ ET+ + E +A + Sbjct: 117 DMTFD------EAYDVFKEVVIAAERAGADIVLIETMSDMLEAKAAILAAKENSNMKVIC 170 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLVV 252 + T ++ G+ VV L G + A+G+NC + + ++ + ++ +P++ Sbjct: 171 TMTFQEDGRTLMGSDPITVVVSLQGL-GLDAIGVNCSTGPDKMVSVVEKMSQVSRIPIIA 229 Query: 253 YPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 PN+G KT + + A + P GA ++GGCC TTP I +K Sbjct: 230 QPNAGMPVIRDGKTV--YDLKPEEFASFFPLLVEKGASIVGGCCGTTPHYIKLVKK 283 >UniRef50_A4J6L9 Methionine synthase (B12-dependent) n=1 Tax=Desulfotomaculum reducens MI-1 RepID=A4J6L9_DESRM Length = 800 Score = 286 bits (733), Expect = 6e-76, Method: Composition-based stats. Identities = 87/295 (29%), Positives = 140/295 (47%), Gaps = 21/295 (7%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K+++L++DGAM T L+ RG L + + +PE ++E+H Y AGA T ++ Sbjct: 8 KKEVLIIDGAMGTLLQQRG--LPGGWCPEEWNLSHPEAVKEIHKLYLEAGADIITTNTFG 65 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A A L + Q K + +V+LA++ + Y A +VAGSVGP G +L Sbjct: 66 AIQLKLADYHLGD-QVKEINQAAVKLAKEVAQPYGA--------MVAGSVGPLGKFLQPL 116 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 + EA+Q F+ + A+++AG DL+ ET + E+ A Sbjct: 117 GTMTFE-----EAYQQFY-EQCAAMVEAGVDLILFETFGDIGEMRAALIAAADAGDVPVV 170 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLV 251 SFT ++ GT A++A + A+G+NC + ++ L T LP++ Sbjct: 171 ASFTFDETGRTFTGTDPETA-AVVAERLGIAAIGVNCSVGPRQLEGVVRKLTESTNLPVL 229 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 V PN+G KT E +A+Y ++ GA ++GGCC TTP I A+ Sbjct: 230 VSPNAGMPEIIGGKTVFR--ETPEIMAEYAQRFVDYGASILGGCCGTTPKHIQAI 282 >UniRef50_Q2LWJ5 5-methyltetrahydrofolate--homocysteine methyltransferase n=6 Tax=Bacteria RepID=Q2LWJ5_SYNAS Length = 813 Score = 286 bits (732), Expect = 7e-76, Method: Composition-based stats. Identities = 84/308 (27%), Positives = 128/308 (41%), Gaps = 24/308 (7%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M +R LL K+ IL+LDGA TEL+ RG + +E+PE+I+E+H Y + Sbjct: 1 MKSKETIRRLLKKK-ILVLDGATGTELQKRGMP--GGVCPELWCLEHPEIIKEIHRSYRQ 57 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AG+ T ++ A A G E + + LAR A LVAG Sbjct: 58 AGSDIVYTCTFGANRYKLAQYGTRE--VREINRNLARLARHAV---------GPKALVAG 106 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 +GP G ++ + E + + +++ LL+ G DL ET+ + E A Sbjct: 107 DIGPTGHFVEPFGDLP------FEEAVSAFKEQIQGLLEGGVDLFVIETMMDIQEARAAL 160 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAAL 239 + A + T + +GT + L A+G NC E A + Sbjct: 161 IAVKETCPAFTVVTLTYENGGRTLNGTDPATALITLQSL-GADAVGCNCSTGPEAMLAFI 219 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 + + +PL PN+G +T+ A + P + AAG L+GGCC TT Sbjct: 220 EAMKPHATVPLAAKPNAGLPRLEGEETFFDMD--AETFASHGPAFAAAGVNLLGGCCGTT 277 Query: 300 PADIAALK 307 P I AL Sbjct: 278 PDHIQALA 285 >UniRef50_C8X6V8 Homocysteine S-methyltransferase n=14 Tax=Actinomycetales RepID=C8X6V8_NAKMY Length = 320 Score = 285 bits (731), Expect = 9e-76, Method: Composition-based stats. Identities = 133/296 (44%), Positives = 177/296 (59%), Gaps = 7/296 (2%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 L+LDG +AT LEA G +L +LWSA++LV+NP I H +Y+RAGAQ AITASYQA+ Sbjct: 14 RPLVLDGGLATLLEAHGHDLTSALWSAQLLVQNPGAITAAHREYFRAGAQVAITASYQAS 73 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAE--NPQAGTLLVAGSVGPYGAYLADG 132 G AA GL +++ + +SV+LAR A + E P +G VA SVGPYGA LADG Sbjct: 74 LPGLAAIGLGRVEAEQALRRSVDLARTAAADGVNEATAPGSGPRWVATSVGPYGAALADG 133 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 SEYRGDY +V + +HRPR+E L DAG D+LA ET+P +E+EAL + A A AW Sbjct: 134 SEYRGDYGLTVRQLRDWHRPRLEILADAGGDVLAIETIPCAAEVEALLTEIQAL-DAPAW 192 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVV 252 S T +D G + +V A+ AG QV+A+G+NC+ + + P VV Sbjct: 193 LSLTCQD-GRTRAGERVDEVFAMAAGVDQVIAVGVNCVESAEAADLVAAAAENSGKPAVV 251 Query: 253 YPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 YPNSGE +DA ++ W ++ W A+GARL+GGCCR P I L Sbjct: 252 YPNSGEDWDAQARAWAGRATFGP---EHAAVWVASGARLVGGCCRVGPQAIRRLAR 304 >UniRef50_A0APQ1 CG10623 protein n=22 Tax=Drosophila RepID=A0APQ1_DROME Length = 331 Score = 283 bits (725), Expect = 4e-75, Method: Composition-based stats. Identities = 113/316 (35%), Positives = 168/316 (53%), Gaps = 22/316 (6%) Query: 12 DKQDILLLDGAMATELEARGCNL--ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITA 69 D + IL+ G +++L D LW ++ NPE + + HLD+ R GA +T Sbjct: 10 DTKPILVKCGGFSSQLAKNVTEKVDGDPLWGSRFDATNPEAVIQTHLDFLRNGADIILTN 69 Query: 70 SYQATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAE---NPQAGTLLVAGSVGPY 125 +YQ++ GF G+ + LI KSV+LA++A+E YL+E ++ L+ GS+GPY Sbjct: 70 TYQSSVEGFVKYLGVTRERGVELIQKSVQLAKQAKEQYLSEIGSEAESALPLIMGSIGPY 129 Query: 126 GAYLADGSEYRGDYHC--SVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL- 182 GAYL DGSEY G+Y S E +A+H+ R+E L AG D LA ETLP E EA+ EL Sbjct: 130 GAYLHDGSEYTGNYADKLSKEELRAWHKTRIEICLAAGVDGLALETLPCLMEAEAVTELV 189 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDV-------VALLAGYPQVVALGINCIALENT 235 L +P A+ W S D +H++ G + V +++ +G+NC+ Sbjct: 190 LDNFPDAKFWVSLQCMDEKHMASGENFAEAALSLWRLVQSRKAENRLLGIGLNCVNPLFV 249 Query: 236 TAALQHLHGLT---VLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLI 292 T L L + +PLVVY N GE YD W GE ++ ++P+W G R++ Sbjct: 250 TPLLSSLTKVAGSDRIPLVVYSNRGEIYDVEQGDWTGTGE---EVVKFVPEWIQLGVRIV 306 Query: 293 GGCCRTTPADIAALKA 308 GGCCR P D+ A++ Sbjct: 307 GGCCRVYPTDVLAIRK 322 >UniRef50_Q9VJ32 CG10621 n=19 Tax=Neoptera RepID=Q9VJ32_DROME Length = 331 Score = 280 bits (716), Expect = 5e-74, Method: Composition-based stats. Identities = 121/315 (38%), Positives = 166/315 (52%), Gaps = 25/315 (7%) Query: 15 DILLLDGAMATELEARGCNL--ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 +L+ DG T++ + D LWSA+ NP I HLD+ + GA +T +YQ Sbjct: 5 RVLVKDGGFGTQMTVHVGDSVDGDPLWSARFNATNPAAIISTHLDFLQNGADIILTNTYQ 64 Query: 73 ATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAE------NPQAGTLLVAGSVGPY 125 ++ G+ LDE QS LI +V LA A+E YL E + Q G L+ S+GP+ Sbjct: 65 SSVDGYMEYLELDEEQSIELIKNTVRLAHIAKERYLTECYQAQLSVQEGYPLIIASIGPF 124 Query: 126 GAYLADGSEYRGDYH--CSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 GA+L DGSEY G Y + +HR R+EA L+AG D LA ET+P E EAL E+L Sbjct: 125 GAHLHDGSEYTGSYADFVPAKEITDWHRVRIEACLEAGVDALAIETIPCQMEAEALVEML 184 Query: 184 -TAYPRARAWFSFTLRDSEHLSDGTPLRDVV-------ALLAGYPQVVALGINCIALENT 235 YP + W +F +D L+ G D A + +A+G+NC+ + Sbjct: 185 CDDYPDVKFWVAFQCKDENTLAHGETFADAANAIWDLLAERNAQDKCLAIGVNCVHPKFV 244 Query: 236 TAALQHLHG----LTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARL 291 T + L+G +PLVVYPNSGE YD V W EHC LA+Y+P+W GA++ Sbjct: 245 TPLFKSLNGDREVGEQIPLVVYPNSGEVYDVV-NGWQGR-EHCVPLANYVPEWAQLGAKV 302 Query: 292 IGGCCRTTPADIAAL 306 IGGCCRT DI + Sbjct: 303 IGGCCRTYARDIRHI 317 >UniRef50_A4XIN5 Methylenetetrahydrofolate reductase n=1 Tax=Caldicellulosiruptor saccharolyticus DSM 8903 RepID=A4XIN5_CALS8 Length = 604 Score = 280 bits (716), Expect = 5e-74, Method: Composition-based stats. Identities = 85/305 (27%), Positives = 128/305 (41%), Gaps = 23/305 (7%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 R L +QDI+L DGAM TEL RG N L + NP+L++ +H DY AG+QC Sbjct: 4 FREFLSQQDIVLFDGAMGTELLNRGYNKDFPL--EWANISNPDLVKSIHSDYILAGSQCI 61 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 T ++ A G E Q + + +V++A++ T V GSVGP G Sbjct: 62 ETNTFGANECRLNLYGF-EGQVEKINRNAVKIAKEVA---------GQTAYVIGSVGPLG 111 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 + G E + + ++ ++ LLD G D + ET + E+ E L Sbjct: 112 KPVGSGFE------IDDKRAKEVYKKQLYFLLDEGVDAILFETAASTHEVLIAIEALKEL 165 Query: 187 P-RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHG 244 F+ G + V+ L G +G+NC T AL+ Sbjct: 166 DSNFPYIVQFSFTRDLTTIYGEDIYKVIEFLKGI-DADVVGLNCGNGPHQTLEALKIFSQ 224 Query: 245 LTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 P V PN+G + + A ++ ++ GA++IGGCC TTP I Sbjct: 225 HLKGPFSVQPNAGYPQLVQGRLVYST--SANYFASFVDEYVKYGAKIIGGCCGTTPEHIK 282 Query: 305 ALKAR 309 A+K R Sbjct: 283 AIKER 287 >UniRef50_C9KQD5 Vitamin B12-dependent methionine synthase family protein n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KQD5_9FIRM Length = 815 Score = 278 bits (712), Expect = 1e-73, Method: Composition-based stats. Identities = 79/295 (26%), Positives = 119/295 (40%), Gaps = 23/295 (7%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 I + DGAM T L+A G + +++PE++R +H Y AGA T ++ A+ Sbjct: 25 IHIFDGAMGTMLQAGGLEAGG--CPELMNIDHPEVVRHIHEAYIEAGATIIETNTFGASR 82 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 GL E + + L +V +A++A VAGS+GP G +++ + Sbjct: 83 LKLDHYGL-EDRVEELNTAAVRIAKEAA---------GTRAKVAGSMGPTGRFISPLGDL 132 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA-YPRARAWFS 194 E A + + AL AG D ET + E+ A P Sbjct: 133 ------DFEEAYACFKEQASALAKAGVDFFIIETCIDIQEMRAALLASKEVAPAIPVICQ 186 Query: 195 FTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLVVY 253 T D GT + +L + +G+NC E ++ L P+ V Sbjct: 187 LTYSDDGRTVTGTDPQSAAIIL-SHMGADIIGVNCSLGPEQLVPIVKTLAASCDCPISVQ 245 Query: 254 PNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 PN+G T G + P+ AAGA +GGCC TTPA I AL+A Sbjct: 246 PNAGMPQLVDGVTHFPMG--PEDFGSWGPKLLAAGATYLGGCCGTTPAHIRALRA 298 >UniRef50_Q49V93 Putative homocysteine S-methyltransferase n=1 Tax=Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 RepID=Q49V93_STAS1 Length = 301 Score = 278 bits (712), Expect = 2e-73, Method: Composition-based stats. Identities = 108/305 (35%), Positives = 162/305 (53%), Gaps = 12/305 (3%) Query: 6 PLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQC 65 L L Q L+LDG +AT LE GC+L SLWS++VL NP I++ H + GA Sbjct: 2 RLLEKLKAQSPLVLDGGLATTLEQAGCSLKTSLWSSEVLKNNPTQIKQAHQAFTDVGADI 61 Query: 66 AITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY 125 +T++YQA+ F+ G+ + L +V +A T ++ GS+GPY Sbjct: 62 LLTSTYQASYQTFSDIGMKATEIDQLYNTAVNQIMEA---------TTDTQVIVGSLGPY 112 Query: 126 GAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE-LLT 184 GAYL+DGSEY G Y S E + FH+ R+EAL+ G + ET+PNF EI+A+ E ++ Sbjct: 113 GAYLSDGSEYTGAYDLSKEDYFQFHKTRIEALVKRGINDFVFETVPNFEEIKAIVEYIVP 172 Query: 185 AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVAL-GINCIALENTTAALQHLH 243 Y W S T+ + LSD T + A + Y + + + GINC ++ A+ Sbjct: 173 HYTNQTFWLSVTVNEDGDLSDDTEFEKLCAYIKQYAERIPVFGINCSSVAGINKAISKGL 232 Query: 244 GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADI 303 + +YPN G Y+AV K W G + + + +P W G ++IGGCC+TTP +I Sbjct: 233 KNVPQTIALYPNGGAQYNAVEKEWESVG-NQGLIVEQIPGWLDQGVKIIGGCCQTTPENI 291 Query: 304 AALKA 308 ++K Sbjct: 292 KSIKE 296 >UniRef50_B9W8L8 Homocysteine S-methyltransferase, putative (S-methylmethionine:homocysteine methyltransferase, putative) n=3 Tax=Candida RepID=B9W8L8_CANDC Length = 311 Score = 277 bits (710), Expect = 2e-73, Method: Composition-based stats. Identities = 106/313 (33%), Positives = 163/313 (52%), Gaps = 20/313 (6%) Query: 6 PLRALLDKQDILLLDGAMATELEAR------GCNLADSLWSAKVLVENPELIREVHLDYY 59 ++ LL+K+ L++DGA+ TELE + LWS +VL++NPEL+ +VHLDY Sbjct: 3 RVKDLLEKKK-LVIDGALGTELERLLPTTSTYLPSSSPLWSGQVLIKNPELVEQVHLDYI 61 Query: 60 RAGAQCAITASYQATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLV 118 AGA IT++YQ + A G D Q+ L ++++A+ A + + +++ Sbjct: 62 NAGADMIITSTYQTSYASLHKYIGYDMDQAVTLWNSALDVAKSAVKKSGRD-----DVII 116 Query: 119 AGSVGPYGAYLADGSEYRGDY-HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE 177 AGS+GPY LA+GSEY GDY S + +H P E ++ D++ ET+P+F E++ Sbjct: 117 AGSIGPYATLLANGSEYNGDYQGVSDQELIEYHTPLFEFYNNSDVDIICIETIPSFQELK 176 Query: 178 ALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGY--PQVVALGINCIALENT 235 + L Y + S + LSDGT L +V L A P+ VA+GINC + EN Sbjct: 177 VIIGLTKKYTSKEFFISINPQTGSALSDGTSLTEVAQLFAEINDPRFVAVGINCTSYENV 236 Query: 236 TAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAA-GARLIGG 294 +L T P+ +YPN G YD + + A+ + +W + IGG Sbjct: 237 DQISTYL---TNFPIFIYPNLGFVYDTTVHKFVSKMLQESAWANSIAKWLNLPNVKAIGG 293 Query: 295 CCRTTPADIAALK 307 CC TTPA+I + Sbjct: 294 CCSTTPAEIQQVA 306 >UniRef50_B9L045 Methylenetetrahydrofolate reductase n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=B9L045_THERP Length = 624 Score = 277 bits (710), Expect = 2e-73, Method: Composition-based stats. Identities = 90/309 (29%), Positives = 136/309 (44%), Gaps = 22/309 (7%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 +P R ++ Q +LL DGAM T+L RG L SA + +P+L+ E+H Y AG Sbjct: 1 MKHPFRDRIE-QGVLLADGAMGTQLYERGIRLDRCFESA--NLTHPQLVVEIHRAYILAG 57 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 A+ T ++ A A G+ E + + + ++V AR+ARE + +AG++ Sbjct: 58 AELIETNTFGANRFKLEAYGMAE-RVREINRRAVRHAREAREIC------GVPVFIAGAI 110 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G LA + E+ + R ++EALL+ G DLL ET+ +EI Sbjct: 111 GPSGRLLAPVG------TVAPESLRPVFREQIEALLEGGVDLLIFETMSQLAEIREAIMA 164 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 T G +VVA LA V +G+NC + T L+ Sbjct: 165 AREVCDLPIVAQMTFAADGRTIAGHGPEEVVAALAEL-GVDVIGVNCSVGPRPTLEVLRA 223 Query: 242 L--HGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 + L PN+G + +G AD+ + + G RLIGGCC TT Sbjct: 224 MIAANRWGTALSAMPNAGWPTVVGHRVI--YGASPEYFADFAREAASLGVRLIGGCCGTT 281 Query: 300 PADIAALKA 308 P IAA++ Sbjct: 282 PEHIAAMRR 290 >UniRef50_A8Q150 Probable homocysteine S-methyltransferase, putative n=1 Tax=Brugia malayi RepID=A8Q150_BRUMA Length = 315 Score = 276 bits (706), Expect = 8e-73, Method: Composition-based stats. Identities = 98/299 (32%), Positives = 152/299 (50%), Gaps = 11/299 (3%) Query: 14 QDILLLDGAMATELEARGCNL-ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 + I +LDG TELEA G N+ +SLWS L +NP+LI +VH + AG+ +T SYQ Sbjct: 8 EKIQILDGGFGTELEAVGYNIENNSLWSCAALFDNPDLILQVHKRFIEAGSDIILTNSYQ 67 Query: 73 ATPAGFA-ARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLAD 131 A + G+ + +++ + K V LA +A + E + + GSVGPYG D Sbjct: 68 ACINTMMSSHGMTKNAAESSLKKLVSLAEQA----INECSVREKVKIVGSVGPYGVIFND 123 Query: 132 GSEYRGDYHCSVEA--FQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRA 189 GSEY G Y +E +H + LL AG ++A ET+P++ E A+ + A + Sbjct: 124 GSEYNGYYVDEIEQQVLVDYHMQQTIPLLQAGLKVIAYETVPSYKEALAILKAADAIGYS 183 Query: 190 R-AWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLH-GLTV 247 W SF+ ++ + + V +A +P ++ +GINC + T LQ + Sbjct: 184 YNFWISFSCKNDKQTNHNEDFCKSVEKIAHHPSILGIGINCTSPNYITPLLQSASTSVNS 243 Query: 248 LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 LP +VYPNSGE Y+ +K W + + L +W+ G +++GGCCR I L Sbjct: 244 LPFIVYPNSGEVYEHSTKKWRIGKCRFPDI-EQLIEWKDLGVKVVGGCCRVGAEKIKEL 301 >UniRef50_C1F3L2 Methylenetetrahydrofolate reductase n=2 Tax=Bacteria RepID=C1F3L2_ACIC5 Length = 636 Score = 275 bits (705), Expect = 1e-72, Method: Composition-based stats. Identities = 89/308 (28%), Positives = 136/308 (44%), Gaps = 17/308 (5%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 NN L+ + + +L DGAM T L ARG + ++ + PEL+R VH DY +AG Sbjct: 1 MNNRLKEIFGDRPVL-CDGAMGTSLYARGIFINRCF--DELNLSQPELVRSVHEDYLQAG 57 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 A+ T ++ A GL + + + +AR A + QAG VAGSV Sbjct: 58 AEIIETNTFGANAIRLRRYGLQDKVA-EINQAGARIARAAVAQLADK--QAGNAWVAGSV 114 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G L + ++ QA ++E L+ G DLL ET+P +E + Sbjct: 115 GPLGVRLEPLGK------VGLDEAQAIFAEQIEGLVAGGVDLLVIETMPALNEAQQAIRA 168 Query: 183 LTA-YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQ 240 A P T+ + DGT A LAG+ A+G+NC A++ Sbjct: 169 ARAVAPELPVIAMVTVDEESRCLDGTAPEVAAARLAGW-GADAVGVNCSTGPAAVLTAIE 227 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 + T LPL PN+G + + +A + ++ +G + +GGCC TTP Sbjct: 228 CMAEATDLPLAAMPNAGMPRAVDGRNIYLC--SPEYMASFARKFHKSGVQFLGGCCGTTP 285 Query: 301 ADIAALKA 308 I A+K+ Sbjct: 286 NHIRAMKS 293 >UniRef50_A0Q0N0 5-methyltetrahydrofolate--homocysteine methyltransferase, putative n=42 Tax=Bacteria RepID=A0Q0N0_CLONN Length = 808 Score = 275 bits (705), Expect = 1e-72, Method: Composition-based stats. Identities = 74/299 (24%), Positives = 121/299 (40%), Gaps = 23/299 (7%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K +IL+ DGAM T L+ G NL +S K+ + LI ++H Y AGA T ++ Sbjct: 15 KDNILIFDGAMGTMLQKSGLNLGES--PEKLNFSHENLIIDIHKKYIEAGANVITTNTFG 72 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A + +I K+V LA KA+E +A +GP G L Sbjct: 73 ANELKLKNTSFS---VEDVIYKAVSLAIKAKE--------DTNCFIALDIGPIGQLLEPM 121 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 + E + +++A + AG DL+ ET+ + E++A + Sbjct: 122 GTLK------FEDAINIFKRQIKAGVKAGVDLILIETMTDLYEMKAAILAAKETCDLPIF 175 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLV 251 + + + G + L V A+G+NC + ++ T LP++ Sbjct: 176 ATMSFENDGRTFTGCLPESMAVTLEAL-GVTAVGVNCSLGPKELKPIVKKTLEHTNLPVI 234 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKARS 310 V PN+G + + + +Y+ G +IGGCC TTP I LK+ S Sbjct: 235 VQPNAGLPTIVNGQ--SLYTITPEEFCNYVESLIDMGVSIIGGCCGTTPDFIKCLKSMS 291 >UniRef50_C8W2L3 Homocysteine S-methyltransferase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8W2L3_DESAS Length = 801 Score = 275 bits (704), Expect = 1e-72, Method: Composition-based stats. Identities = 84/306 (27%), Positives = 131/306 (42%), Gaps = 25/306 (8%) Query: 9 ALLDK--QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 +DK + IL+ DGAM T L+A G + + ++NPE ++ +H Y +AGA Sbjct: 2 RFIDKLAEKILVFDGAMGTMLQAAGLRAGE--CPELINLKNPETVKNIHRQYVKAGADIV 59 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 T ++ + GL + + + +V LA+++ + G LVA SVGP G Sbjct: 60 ETNTFGGSRLKLLEYGLADKVA-EINASAVRLAKESAD---------GQALVALSVGPTG 109 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE-ALAELLTA 185 + D ++ A AGAD++ ET+ + EI AL A Sbjct: 110 KLMFPNGPLTFD------EAHHVFSEQISAGAAAGADMICIETMSDLGEIRAALLAAKDA 163 Query: 186 YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHG 244 P S T ++ GT V L +G NC ++ + Sbjct: 164 APGVPVICSMTFEPNKRTLMGTDPVAAVITLQAL-GADIIGANCSGGPGELLEVIEEMAR 222 Query: 245 LTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 +PL+V PN+G +T A++ +Y+P+ AAGA LIGGCC T+P I Sbjct: 223 YARVPLIVQPNAGMPMLEGDRTV--FPLSAAEMGEYVPKLAAAGASLIGGCCGTSPEYIR 280 Query: 305 ALKARS 310 +K RS Sbjct: 281 VIKERS 286 >UniRef50_Q5ZBZ6 Os01g0772900 protein n=3 Tax=Magnoliophyta RepID=Q5ZBZ6_ORYSJ Length = 328 Score = 274 bits (702), Expect = 2e-72, Method: Composition-based stats. Identities = 125/303 (41%), Positives = 169/303 (55%), Gaps = 40/303 (13%) Query: 18 LLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPAG 77 ++DG +ATELEA G +L D LWSA LV P LIR+VHLDY AGA +ASYQAT G Sbjct: 26 VVDGGLATELEAHGADLHDELWSASCLVSAPHLIRKVHLDYLDAGANIITSASYQATIQG 85 Query: 78 FAARGLDEAQSKALIGKSVELARKAREAYLA----------ENPQAGTLLVAGSVGPYGA 127 F ARGL +S+AL+ +SV +A++AR + + +LVA S+G YGA Sbjct: 86 FQARGLSRERSEALLRRSVHIAQEARAIFAEGWSKGPYANHRSSPRRPVLVAASIGSYGA 145 Query: 128 YLADGSEYRGDYHCSV--EAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA 185 YLADGSEY GDY SV E ++FHR R++ L DAG DL+A ET+PN E +A Sbjct: 146 YLADGSEYTGDYGISVTKETLKSFHRRRLQVLADAGPDLIAFETIPNKLEAQA------- 198 Query: 186 YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL 245 G P+ + A+ +V A+G+NC A + + + Sbjct: 199 -------------------SGDPITECAAVADACARVGAVGVNCTAPRLVHGLILSIRKV 239 Query: 246 TVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQ--LADYLPQWQAAGARLIGGCCRTTPADI 303 T P+VVYPNSGE Y A +K W ++ + +W+ AGA L+GGCCRT+PA + Sbjct: 240 TSKPVVVYPNSGETYVAETKEWVESEGGASETDFVSCVGKWRQAGAALVGGCCRTSPATV 299 Query: 304 AAL 306 A+ Sbjct: 300 RAI 302 >UniRef50_B9MN09 Methylenetetrahydrofolate reductase n=2 Tax=root RepID=B9MN09_ANATD Length = 605 Score = 272 bits (697), Expect = 8e-72, Method: Composition-based stats. Identities = 81/309 (26%), Positives = 131/309 (42%), Gaps = 23/309 (7%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 R L +Q I++ DGAM T+L RG ++ L V NPEL++++H DY AG Sbjct: 1 MKKSFREFLKEQAIVIFDGAMGTQLLLRGFSVDFPL--EWANVANPELVKQIHTDYILAG 58 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 A C T ++ A G E + + + +V +A++ E + V GSV Sbjct: 59 ATCVETNTFGANECKLKVFGF-ENEVERINRSAVRIAKEVAE---------NKVYVIGSV 108 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G + +G E + + ++ ++ LLD G D + ET + E++ E Sbjct: 109 GPLGKPVGNGFE------IDDKKAKDVYKRQLYFLLDEGVDAIIFETAASTHEVQIAIEA 162 Query: 183 LTAYPRA-RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQ 240 L F+ G + V+ L +G+NC + T AL+ Sbjct: 163 LKELNDKIPYIIQFSFTKELSTVYGEDIYRVIEFLKST-NADVVGLNCGNGPQKTLEALK 221 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 P V PN+G Y + + A ++P++ GA++IGGCC T P Sbjct: 222 IFSQHLKGPFSVQPNAG--YPQLIQGRPVFSTSANYFASFVPEYIKLGAKIIGGCCGTGP 279 Query: 301 ADIAALKAR 309 I A+K + Sbjct: 280 EHIKAVKEK 288 >UniRef50_Q2JJL4 Methionine synthase n=30 Tax=Bacteria RepID=Q2JJL4_SYNJB Length = 1224 Score = 272 bits (695), Expect = 1e-71, Method: Composition-based stats. Identities = 81/317 (25%), Positives = 134/317 (42%), Gaps = 28/317 (8%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREVHL 56 +P L ++ +++ DGAM + L+A+ AD + +++ PE + VH Sbjct: 1 MTHPFLQHL-QERVIVFDGAMGSSLQAQNLTAADFGGPELEGCNEMLVLTKPEAVERVHR 59 Query: 57 DYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTL 116 + GA T ++ AT A G+ E ++ L + LA++ + Sbjct: 60 GFLEVGADVVETNTFGATSIVLAEYGIPE-KAYELNVAAARLAKRVAAEFATP---EKPR 115 Query: 117 LVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEI 176 VAGS+GP G H S + +A + +V+ L+D GADLL ET + + Sbjct: 116 FVAGSIGPTTKLPTLG-------HISFDEMRAAYEEQVQGLVDGGADLLIIETCQDILQT 168 Query: 177 EALA-----ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-I 230 +A E R S T + GT + +A+L YP + LG+NC Sbjct: 169 KAALVAVQQEFARRGIRLPVVVSLTFEVQGTMLVGTEIGAALAILEPYP-IDVLGLNCAT 227 Query: 231 ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ-AAGA 289 + +++L + P+ PN+G + K H+ QL +L + G Sbjct: 228 GPDKMVEHIRYLSRHSPFPISCIPNAGLPENIGGKA--HYKLTPEQLRFHLEHFVRDLGV 285 Query: 290 RLIGGCCRTTPADIAAL 306 ++GGCC T P IAAL Sbjct: 286 AVVGGCCGTRPEHIAAL 302 >UniRef50_B8CZI7 Homocysteine S-methyltransferase n=1 Tax=Halothermothrix orenii H 168 RepID=B8CZI7_HALOH Length = 819 Score = 269 bits (688), Expect = 8e-71, Method: Composition-based stats. Identities = 76/296 (25%), Positives = 133/296 (44%), Gaps = 24/296 (8%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 ++ I++ DGAM T L+A G + + +++ P+ I ++H +Y AGA T ++ Sbjct: 10 QEKIIIGDGAMGTMLQACGLSSGHA--PESWVIKKPDTIYKIHKEYVAAGAGLIETNTFG 67 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A + GL E + + + K+ LARKA G + VAGSVGP G + Sbjct: 68 ANRLKLKSLGL-EDKIEEINVKATGLARKAA----------GKVFVAGSVGPTGKLMEPH 116 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 + D + + ++ L+ AG D++ ET+ + E+ A + Sbjct: 117 GDLSFDRA------RDVFKEQISYLVHAGVDVVIIETMSDLKELRAAVVAAKEF-NVPVI 169 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLV 251 T + G+P +VVA++ V +G+NC+ +E ++ + +T PL Sbjct: 170 AQMTFTERGITLTGSPP-EVVAIVLDKMGVDVIGVNCVAGIEEALIVIKKMSRVTSKPLS 228 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 V+PN+G +T + + D +P+ +LIGGCC T P I +K Sbjct: 229 VFPNAGLPESKGGETV--YPQTPDAFTDKIPELLKYNVKLIGGCCGTNPRFIKGIK 282 >UniRef50_C3WBE7 Methionine synthase n=1 Tax=Fusobacterium mortiferum ATCC 9817 RepID=C3WBE7_FUSMR Length = 1084 Score = 269 bits (688), Expect = 1e-70, Method: Composition-based stats. Identities = 67/308 (21%), Positives = 123/308 (39%), Gaps = 25/308 (8%) Query: 13 KQDILLLDGAMATELEARGCNLADSL----WSAKVLVENPELIREVHLDYYRAGAQCAIT 68 ++ IL+LDGAM T ++ N D L + + + P++I+++HL Y AGA T Sbjct: 11 QKRILVLDGAMGTAIQKYNLNSDDYLGKKGCNEILNITRPDIIKDIHLKYIEAGADIIET 70 Query: 69 ASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 S+ G E ++ + +S ELA++ + +AGS+GP Sbjct: 71 NSFNCNKISLNEYGFSE-RAYEIAKRSAELAKEV------TTTSEKKIYIAGSIGPTNKT 123 Query: 129 LA-DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE-----L 182 L + D + + + ++E L+D G D+L ET+ + + + Sbjct: 124 LTIPSGKNPYDRDLEFDYLKEAYSEQIEGLIDGGVDILLIETIFDGLNAKCAVISAEEVM 183 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQH 241 S T+ + G + ++ L +++ G NC + + Sbjct: 184 KRKNINLPIMISATVNKEGKIFTGQSIESLIVAL-DRESIISYGFNCSFGAKELIPLTKK 242 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQA-AGARLIGGCCRTTP 300 L T P+ +YPN+G + + E A+YL + ++GGCC TT Sbjct: 243 LGKFTKKPISLYPNAGLPNEDG-----EYLESPDITANYLKELVDNQEVNILGGCCGTTF 297 Query: 301 ADIAALKA 308 I ++ Sbjct: 298 EHIKSIAN 305 >UniRef50_A5IKF3 Methionine synthase (B12-dependent) n=6 Tax=Thermotogaceae RepID=A5IKF3_THEP1 Length = 768 Score = 268 bits (686), Expect = 2e-70, Method: Composition-based stats. Identities = 78/310 (25%), Positives = 124/310 (40%), Gaps = 27/310 (8%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M + LL + +LLLDGA TE G + ++ ++ P+++ +VH Y Sbjct: 1 MRNRREVSKLLS-ERVLLLDGAYGTEFMKYGYDDL----PEELNIKAPDVVLKVHRSYIE 55 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 +G+ +T ++ AT GL E + ++ +V +AR+A G LV G Sbjct: 56 SGSDVILTNTFGATRMKLRKHGL-EDKLDPIVRNAVRIARRAA----------GEKLVFG 104 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 +GP G + E F R V+ +++ G D + ET + E++A Sbjct: 105 DIGPTGELPYPLG------NTLFEEFYENFRETVKIMVEEGVDGIIFETFSDILELKAAV 158 Query: 181 ELLTAYPRARAWFS-FTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAA 238 R + T + GT + A+ V ALGINC E Sbjct: 159 LAAREVSRDVFLIAHMTFDEKGRSLTGTDPAN-FAITFDELDVDALGINCSLGPEEILPI 217 Query: 239 LQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRT 298 Q L T LVV PN+G+ KT + H A ++ + G + GGCC T Sbjct: 218 FQELSQYTDKFLVVEPNAGKPIVENGKTVYPLKPH--DFAVHIDSYYELGVNIFGGCCGT 275 Query: 299 TPADIAALKA 308 TP + + Sbjct: 276 TPEHVKLFRK 285 >UniRef50_Q0AX05 Methionine synthase (B12-dependent) n=1 Tax=Syntrophomonas wolfei subsp. wolfei str. Goettingen RepID=Q0AX05_SYNWW Length = 839 Score = 267 bits (684), Expect = 3e-70, Method: Composition-based stats. Identities = 73/299 (24%), Positives = 123/299 (41%), Gaps = 22/299 (7%) Query: 11 LDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITAS 70 L + IL+LDGAM T L+ RG + V NP ++ ++H Y AGA + + Sbjct: 8 LLQSRILILDGAMGTMLQERGMVPGE--CPELFGVNNPLILEDIHYQYMEAGADIIQSNT 65 Query: 71 YQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLA 130 + A GL + + + +++ +AR G LVA S+GP G L Sbjct: 66 FGGNRFKLAEYGLQD-RVAEINAEAIRIARAGA---------RGKALVAASIGPSGKLLQ 115 Query: 131 DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRAR 190 + A ++ + AGADL++ ET+ + E+ A + R Sbjct: 116 PFG------NADFAELYAAFTEQMLSCEKAGADLISIETMTDIGEMRAALIAACSNTRLP 169 Query: 191 AWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALE-NTTAALQHLHGLTVLP 249 T GT + ++ Q +A+G NC ++ + + + Sbjct: 170 VIAHMTFEPGGRTLMGTDPLTALIIMEAL-QPLAIGANCSGGARELLPIIEEMGRYSSVF 228 Query: 250 LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 L V PN+G +T + ++A+Y + + GA +IGGCC TTP I A+ + Sbjct: 229 LSVEPNAGLPQLLGERTV--FPDRPEEMAEYALKLRDVGANIIGGCCGTTPEHIKAIAS 285 >UniRef50_A4XIN4 Homocysteine S-methyltransferase n=1 Tax=Caldicellulosiruptor saccharolyticus DSM 8903 RepID=A4XIN4_CALS8 Length = 411 Score = 267 bits (683), Expect = 3e-70, Method: Composition-based stats. Identities = 73/301 (24%), Positives = 127/301 (42%), Gaps = 26/301 (8%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 + +L+ DGAM T+L G L ++ V PE+I ++H DY+ AG+ C T ++ A Sbjct: 8 KKVLVFDGAMGTQLIQNG--LKENECPDLWSVTRPEVIAKIHRDYFEAGSDCVETNTFGA 65 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 GL E + + + ++ LA+ + Y V SVGP G + Sbjct: 66 NREKLKKYGL-ENEVEKINKAAILLAKDVAKEYGG--------YVGLSVGPTGRLMRPSG 116 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT-----AYPR 188 + + ++ ++ A ++AGAD ++ ET+ + E +A A Sbjct: 117 DL------DFDEAESVFYEQILAGIEAGADFISIETMSDIKEAKAAFLAYKRAKENANKD 170 Query: 189 ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTV 247 S T +++ L GTP +V A + +G NC + ++ ++G + Sbjct: 171 VACLVSLTFEENKRLLMGTPP-EVAAYFFSFIGADLVGANCSGGAKQLLDVIKSMNGFSF 229 Query: 248 LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 +PL PN+G K + + A ++ +G RL GGCC T P I A+ Sbjct: 230 VPLSTKPNAGLPKMIDGKVVYE--DCIADFESSTEEFIQSGVRLYGGCCGTNPEYIKAIA 287 Query: 308 A 308 Sbjct: 288 K 288 >UniRef50_Q67LG1 5-methyltetrahydrofolate S-homocysteine methyltransferase n=2 Tax=Clostridiales RepID=Q67LG1_SYMTH Length = 859 Score = 266 bits (680), Expect = 7e-70, Method: Composition-based stats. Identities = 88/304 (28%), Positives = 130/304 (42%), Gaps = 23/304 (7%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 L +L ++ +L+ DGAM T L+A+G LA +E PE + VH Y AGAQ Sbjct: 3 LEDMLGRE-VLVFDGAMGTMLQAQG--LAPGACPDVWNLERPEDVIAVHRAYVEAGAQIL 59 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 T ++ +TP GL + + + ++ V AR+A AG VAGS+GP G Sbjct: 60 ETNTFGSTPIRLGHYGLQD-RCRDIVVAGVRCAREAA---------AGRAWVAGSMGPLG 109 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA- 185 A + E D EA+ F + A +A D + ET+ + +E+ A Sbjct: 110 ALVEPLGELPFD-----EAYAQF-AVQARAFAEAQPDFIIIETIADLNELRAAVLACRDH 163 Query: 186 YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHG 244 P R TL S GT +L +G NC + + A+ + Sbjct: 164 APGIRIIAQITLDPSGRAFTGTDPETAALVLQSL-GADVIGFNCSVGPDLLVEAVARMAR 222 Query: 245 LTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 + +P+ V PN+G + A Y P+ AGA L+GGCC TTP I Sbjct: 223 VARVPISVQPNAGLPL-LQPDGATRFPMGPEEFAAYGPKLVEAGAALVGGCCGTTPEHIR 281 Query: 305 ALKA 308 L+A Sbjct: 282 RLRA 285 >UniRef50_C5MAR2 Putative uncharacterized protein n=1 Tax=Candida tropicalis MYA-3404 RepID=C5MAR2_CANTT Length = 312 Score = 266 bits (680), Expect = 7e-70, Method: Composition-based stats. Identities = 92/309 (29%), Positives = 156/309 (50%), Gaps = 21/309 (6%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADS------LWSAKVLVENPELIREVHLDYYR 60 + + ++ L++DGA+ TELE + + S LWS + L+ NPEL+ +VHLDY Sbjct: 4 FKEIFQQKK-LVIDGALGTELERLLPSSSASLPSNSPLWSGQALINNPELVEQVHLDYIN 62 Query: 61 AGAQCAITASYQATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVA 119 AGA IT++YQ + A G D +S L ++ A+ A +++A Sbjct: 63 AGADIIITSTYQTSYASLNKYAGYDMKKSVELWNSALGAAKNAVN-----RSGRSDVIIA 117 Query: 120 GSVGPYGAYLADGSEYRGDY-HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 GS+GPY LA+GSEY GDY + + +H P E ++ D++ ET+PNF+E++ Sbjct: 118 GSIGPYATVLANGSEYSGDYQGATYDDLVEYHTPLFEFYDNSDVDVICIETIPNFTELKV 177 Query: 179 LAELLTAYPRARAWFSFTLRDSEHLSDGTPL---RDVVALLAGYPQVVALGINCIALENT 235 + +++ Y + + + + + LSDGT L +V + + + +GINC + Sbjct: 178 VIDMMKKYTKKEYFIAVNPQTANALSDGTTLDKVAEVFKTIEDTSRFLGVGINCTNYDLV 237 Query: 236 TAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQA-AGARLIGG 294 L++ T P+++YPN G YD + + H + + +W R +GG Sbjct: 238 NDILKY---FTDFPVLIYPNMGFVYDTETHKFVPEANHELSWENAVKKWLNSDNVRAVGG 294 Query: 295 CCRTTPADI 303 CC T P++I Sbjct: 295 CCSTGPSEI 303 >UniRef50_A9B073 Methionine synthase n=2 Tax=Bacteria RepID=A9B073_HERA2 Length = 1180 Score = 266 bits (680), Expect = 8e-70, Method: Composition-based stats. Identities = 83/320 (25%), Positives = 139/320 (43%), Gaps = 22/320 (6%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADS----LWSAK--VLVENPELIREV 54 M+ P A L K +L+ DGAM T L+ D + A+ + + P++I ++ Sbjct: 1 MTSIKPYIAELAK-RVLIYDGAMGTSLDLYDLKPEDFGGEQYFGARDYLALTRPDIIEQI 59 Query: 55 HLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAG 114 H + AG T ++Q+T GL + + K+ +LARK + Y A+ Sbjct: 60 HSSFMEAGVDVLETNTFQSTRIRLHEWGLADKTYEQ-NFKAAQLARKVADRYQAQ--DGR 116 Query: 115 TLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFS 174 VAGS+GP G S+ + + +A + + AL++ G D+L ET + Sbjct: 117 KRFVAGSMGPTGFL--PSSDDPTLSNITWDALSDTFKEQTIALVEGGVDVLLVETSVDIL 174 Query: 175 EIEALAELLT------AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGIN 228 E++A + + P L S + GT ++ + L V +G+N Sbjct: 175 EVKAAIDGIRRGLAELKRPDIAIQAQVFLDLSGRMLLGTDIQATMVTLEALADVDVIGLN 234 Query: 229 C-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ-A 286 C E+ A+ +L + LP+ PN+G + +T A A L ++ Sbjct: 235 CSTGPEHMRPAITYLAANSKLPISCIPNAGLPMEVNGETV--FPLEPAGFAKSLTEFVQD 292 Query: 287 AGARLIGGCCRTTPADIAAL 306 G R++GGCC TTPA + AL Sbjct: 293 LGVRVVGGCCGTTPAHLRAL 312 >UniRef50_A6TTI3 Homocysteine S-methyltransferase n=6 Tax=Firmicutes RepID=A6TTI3_ALKMQ Length = 789 Score = 266 bits (680), Expect = 8e-70, Method: Composition-based stats. Identities = 73/297 (24%), Positives = 119/297 (40%), Gaps = 26/297 (8%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K+ +L+ DGAM T L+ G + +E+PELI+++H + RAGAQ T ++Q Sbjct: 8 KEGMLIFDGAMGTMLQKSGLKVG--ALPEIYNIEHPELIQQIHERFVRAGAQVVTTNTFQ 65 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A + +I +++A+ +G VA +GP G + Sbjct: 66 ANELKLKDSIYS---LEEIIEGGIKVAK-----------ASGAPYVALDIGPLGQMMKPL 111 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 E S + + +V+A + AGAD + ET+ + E +A Sbjct: 112 GE------ISFDRAYDIFKRQVQAGVKAGADCILIETISDLYEAKAAILAAKENSDLPVL 165 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLV 251 + T ++ GT L+ V ALG+NC + L + +P++ Sbjct: 166 CTMTFQEDGRTFTGTDPMTA-TLVLQSLGVDALGVNCSLGPKEMLPILSDILKYAKVPVM 224 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 V N+G T + A Y + G ++GGCC TTP I ALK Sbjct: 225 VQSNAGLPRLEGDDTI--FPASPEEFALYGREMAELGVGILGGCCGTTPEHIQALKK 279 >UniRef50_C4XYV2 Putative uncharacterized protein n=1 Tax=Clavispora lusitaniae ATCC 42720 RepID=C4XYV2_CLAL4 Length = 329 Score = 265 bits (679), Expect = 1e-69, Method: Composition-based stats. Identities = 111/335 (33%), Positives = 171/335 (51%), Gaps = 40/335 (11%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEAR------GCNLADSLWSAKVLVENPELIREV 54 MS L K+ +L+ DGA+ T+LEA LWS L+ +PELI + Sbjct: 1 MSFKEAL-----KKSVLVQDGALGTQLEALIPLDDPHSVKGSPLWSTNALLYSPELISSI 55 Query: 55 HLDYYRAGAQCAITASYQATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQA 113 H Y AGA ITA+YQA+P + +D AQ+K + KSVE A +A + + Sbjct: 56 HKQYVEAGADMIITATYQASPQTLSKYENMDLAQAKKVWTKSVECALEATRTHPEK---- 111 Query: 114 GTLLVAGSVGPYGAYLADGSEYRGDY-HCSVEAFQAFHRPRVEALLDAG-ADLLACETLP 171 + + GS+GPYGAYLA+G+EY GDY S + +HR V + D++A ET+P Sbjct: 112 -KIFIGGSIGPYGAYLANGAEYSGDYGDISSDQLMDYHRDIVRFYAETKEVDVIAFETVP 170 Query: 172 NFSEIEA----LAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAG------YPQ 221 NF+E++A + ++ A + S + +D++HL DGTPL V+ + Sbjct: 171 NFAEVQAIFSLIEQMFNANLHKEFYVSLSCKDADHLVDGTPLEQVIRYILSKKSSQISDN 230 Query: 222 VVALGINCIALENTTAALQHLHGLT------VLPLVVYPNSG-EHYDAVSKTWHHHGEHC 274 +V +G NC+ E + ++ ++ + L L+VYPN G E D + + E Sbjct: 231 LVGIGCNCVPFEIVSDFIETVNRVCQNNGSEQLSLLVYPNLGFEPTDTANYAFRSSTE-- 288 Query: 275 AQLADYLPQWQA-AGARLIGGCCRTTPADIAALKA 308 + A + +W + R+IGGCC T PA+IA +K Sbjct: 289 -KWASSVAKWALYSNVRVIGGCCSTGPAEIAQIKD 322 >UniRef50_D0NSW2 Homocysteine S-methyltransferase, putative n=1 Tax=Phytophthora infestans T30-4 RepID=D0NSW2_PHYIN Length = 332 Score = 265 bits (678), Expect = 1e-69, Method: Composition-based stats. Identities = 120/314 (38%), Positives = 170/314 (54%), Gaps = 17/314 (5%) Query: 10 LLDKQDILLLDGAMATELEA--RGCNLADSLWSAKVLVEN----PELIREVHLDYYRAGA 63 L DK +++LDG ATELE R A SLWS +L++ +++ H +Y+ AGA Sbjct: 13 LADKSRVVVLDGGFATELEKDPRVDLSASSLWSGSLLLDQNQHLQDVVVNAHTNYFLAGA 72 Query: 64 QCAITASYQATPAGFAARGLDE-AQSKALIGKSVELARKAREAYLAENPQAGTL--LVAG 120 A T SYQA+ GF G+ + L KS++L +AR+A E Q+ + LV Sbjct: 73 DVATTVSYQASVDGFKREGVTALEDVEKLFAKSIDLGAQARDAAWNELQQSKRIKPLVGA 132 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLD-AGADLLACETLPNFSEIEAL 179 S+G YGA LADGSEYRGDY + A+H+ R A A+ L CET+P E+EA Sbjct: 133 SIGCYGAALADGSEYRGDYGKTKNELVAWHKHRFAFFTSYAPANFLICETIPCLVEVEAF 192 Query: 180 AELLTAYPRARAWFSFTLRDSEHLSDGTPLR---DVVALLAGYPQVVALGINCIALENTT 236 +LL +P A A + + + L+ G P+ +++A L Q++A+GINC + Sbjct: 193 VDLLNEFPTAHAIVAVACHNGKELNSGEPIARIPEILAKLNNPSQLLAIGINCTPPQYVE 252 Query: 237 AALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEH--CAQLADYLPQWQAAGARLIGG 294 + L L P VYPNSGE +D V+K W + +YLP+W AGAR GG Sbjct: 253 SLLLELD--CPWPKAVYPNSGEGWDGVNKKWLPADNTGGPSSWEEYLPKWYDAGARFFGG 310 Query: 295 CCRTTPADIAALKA 308 CCRT+P DI A++ Sbjct: 311 CCRTSPDDIRAIRE 324 >UniRef50_Q01QP4 Methylenetetrahydrofolate reductase n=2 Tax=Acidobacteria RepID=Q01QP4_SOLUE Length = 622 Score = 265 bits (677), Expect = 2e-69, Method: Composition-based stats. Identities = 81/312 (25%), Positives = 137/312 (43%), Gaps = 25/312 (8%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRA 61 S+ R L + +++ DGAM T L +RG + ++ + +++R++H +Y +A Sbjct: 7 SRAQEFRDQLA-RRVIVADGAMGTMLYSRGVFINRCF--DELNLSAADMVRQIHQEYVKA 63 Query: 62 GAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGS 121 GA+ T ++ AT A G E + +A+ V LAR+A G+ VAG+ Sbjct: 64 GAEILETNTFGATRQRLGAFGFAE-KLQAINHAGVRLAREAAN---------GSAYVAGA 113 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEAL-- 179 VGP + S +A R +++ALL+AG DLL ET N E+ Sbjct: 114 VGPLNVRIEPLG------PTSFAEARAAFREQIDALLEAGVDLLIFETFGNLDELREAVY 167 Query: 180 AELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAA 238 A + T+ D HL GT + +P V +G+NC + + T Sbjct: 168 AGYDASRGEVPMIAQVTIDDFGHLPGGTDTETFTREMNNWP-VDVIGLNCSVGPKATLET 226 Query: 239 LQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRT 298 ++ + PL PN+G + + ++ Y + AG ++IGGCC T Sbjct: 227 VERMMEFATKPLSAMPNAGLPMRVEGRNIYLC--SPEYMSQYARRLLWAGVKVIGGCCGT 284 Query: 299 TPADIAALKARS 310 TP I +++ + Sbjct: 285 TPDHIKLIRSET 296 >UniRef50_B9MN08 Homocysteine S-methyltransferase n=1 Tax=Anaerocellum thermophilum DSM 6725 RepID=B9MN08_ANATD Length = 413 Score = 264 bits (676), Expect = 2e-69, Method: Composition-based stats. Identities = 70/301 (23%), Positives = 122/301 (40%), Gaps = 30/301 (9%) Query: 14 QDILLLDGAMATELEARGC--NLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 + +L+ DGAM T+L G + LWS V +++ +H Y+ AG+ C T ++ Sbjct: 10 RRVLIFDGAMGTQLIQNGLTEDECPDLWS----VTRQDVVSSIHRQYFEAGSDCVETNTF 65 Query: 72 QATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLAD 131 A GL E + + + +V+LA++ + Y V SVGP G Sbjct: 66 GANREKLKKYGL-ENEVENINKCAVKLAKEVAKEYSG--------YVGLSVGPTGRLFIP 116 Query: 132 GSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA-----Y 186 + S + ++ ++ + ++AGAD ++ ET+ + E +A Sbjct: 117 SGDL------SFDEAESIFYEQILSGIEAGADFVSIETMSDIKEAKAAFFAYKKAKEELK 170 Query: 187 PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALE-NTTAALQHLHGL 245 S T ++ L GTP +V A +G NC ++ + Sbjct: 171 KDIPCLISLTFEQNKRLLMGTPP-EVAAYYFSSIGCDIVGANCSGGAIQLLEIIKQMQFF 229 Query: 246 TVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAA 305 + +PL V PN+G KT + + + ++ G RL GGCC T P I + Sbjct: 230 SFVPLSVKPNAGLPKVVDGKTIYES--CIPEFVNLADEFVENGVRLYGGCCGTNPEYIKS 287 Query: 306 L 306 + Sbjct: 288 I 288 >UniRef50_A3ERA3 5-methyltetrahydrofolate--homocysteine methyltransferase n=3 Tax=Leptospirillum RepID=A3ERA3_9BACT Length = 815 Score = 264 bits (675), Expect = 3e-69, Method: Composition-based stats. Identities = 87/307 (28%), Positives = 139/307 (45%), Gaps = 30/307 (9%) Query: 7 LRALLD--KQDILLLDGAMATELEARGCNL--ADSLWSAKVLVENPELIREVHLDYYRAG 62 ++ LL+ K +ILLLDG+M L++RG A LW +E P+ I++VH +Y AG Sbjct: 1 MKPLLERLKNEILLLDGSMGALLQSRGLPPGYAPDLW----NLERPQDIQQVHSEYVEAG 56 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 + +T ++ ++ E Q + + VE+AR+A G VAG + Sbjct: 57 SDIILTNTFGSSRLRLREYD-AEGQIREINEAGVEMARRA---------SRGKAYVAGDI 106 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G +A + D +A F+ + LL+AG DL+A ET+ + E+ A Sbjct: 107 GPSGTTIAPFGDLPFD-----DAIGIFY-EQARILLEAGVDLIAIETMFDIQEMRAALIG 160 Query: 183 LTAY--PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAAL 239 + R T + G+ ++L G+ V LG+NC + E + Sbjct: 161 VREAVGNRIPVMALMTFNNDGITDSGSDPETAASVLEGF-GVEILGLNCSVGPEAMVPVV 219 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 + L T + V PN+G T + + +A + PQ+ AGA +IGGCC TT Sbjct: 220 RRLGQTTSTFIAVEPNAGLPVHRDGHTV--YPANAEDVARFAPQFVEAGANIIGGCCGTT 277 Query: 300 PADIAAL 306 P + L Sbjct: 278 PEYVRLL 284 >UniRef50_C0QRY9 Methionine synthase n=3 Tax=Bacteria RepID=C0QRY9_PERMH Length = 1182 Score = 263 bits (673), Expect = 5e-69, Method: Composition-based stats. Identities = 72/313 (23%), Positives = 135/313 (43%), Gaps = 26/313 (8%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNL----ADSLWSAKVLVENPELIREVHLDYYRAG 62 +R L+ K+ +L++DGAM T +++ + + + + V P++IR +H Y AG Sbjct: 4 IRDLIGKK-VLVIDGAMGTMIQSMIIPMEAWEGKTGCNEILNVTAPDVIRSIHEKYALAG 62 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 A T ++ A P G+ + ++ L EL R+ + Y VAGS+ Sbjct: 63 ADLIKTNTFGALPWVLEEYGISD-RAYELSKAGAELVRQVCDKYSTP---EKPRFVAGSL 118 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G++ H + +R + L+D G D+ ET + +I+A Sbjct: 119 GP-------GTKLPSLGHIDYDEMYEGYRISAKGLIDGGVDIFLLETFQDPLQIKAALHA 171 Query: 183 LTAY-----PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTT 236 + S T+ + + GT ++ + ++ + ++ LG NC + Sbjct: 172 VQDTAEEYGKDIPVMVSATIELTGTMLIGTDVQTLAVIMEPF-DILTLGFNCGTGPDQIE 230 Query: 237 AALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQA-AGARLIGGC 295 + L+ L + + ++ N+G + T++ G + AD ++ G ++GGC Sbjct: 231 SHLKKLSQVWDGYISIHSNAGLPENRGGHTYYPMG--AEEFADKESRFLDFDGVAVVGGC 288 Query: 296 CRTTPADIAALKA 308 C TTPA I AL Sbjct: 289 CGTTPAHIKALAE 301 >UniRef50_D1CBD0 Methylenetetrahydrofolate reductase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CBD0_THET1 Length = 629 Score = 263 bits (673), Expect = 6e-69, Method: Composition-based stats. Identities = 85/307 (27%), Positives = 134/307 (43%), Gaps = 20/307 (6%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 +P L+K IL DGA+ T+L RG S ++ + +P L+ VH+DY RAG Sbjct: 1 MKDPFVERLEKGPIL-SDGAIGTQLYERGVPYGKSF--DELNIVDPSLVSGVHIDYLRAG 57 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 A+ T ++ A GL E + + + + V++AR+ARE +AGSV Sbjct: 58 AEIITTNTFGANRIRLKEFGL-EKKVRDINLRGVKIAREAREIV------GVPAFIAGSV 110 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G +EY + R ++EALL+ GAD++ ET E+ E+ Sbjct: 111 GPIGR---PATEYN---SLTDRVIGDTFREQIEALLEGGADVIMFETFSELEELLIAIEV 164 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 + + E G D V L V +G+NC + + T + Sbjct: 165 AKEVCELPIIAQMSFGEDELTHGGDTPEDFVRALKD-SDVDVIGVNCSVGPQGTLDVVMR 223 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 L + PN+G + + A+Y ++ +AGA ++GGCC TTPA Sbjct: 224 LIAAGAHRVSAQPNAGLP--SRRGQHFVYISTPEYFAEYAKKFVSAGAVIVGGCCGTTPA 281 Query: 302 DIAALKA 308 I+A+ A Sbjct: 282 HISAMAA 288 >UniRef50_C6HW85 5-methyltetrahydrofolate--homocysteine methyltransferase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HW85_9BACT Length = 822 Score = 263 bits (672), Expect = 7e-69, Method: Composition-based stats. Identities = 86/298 (28%), Positives = 136/298 (45%), Gaps = 27/298 (9%) Query: 13 KQDILLLDGAMATELEARGCNL--ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITAS 70 K+DIL+LDG+M L+ RG A LW +E P+ I+ VH +Y AG+ +T + Sbjct: 9 KKDILILDGSMGALLQGRGLPPGYAPDLW----NLERPKDIQAVHAEYRAAGSDILLTNT 64 Query: 71 YQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLA 130 + A+ A E + + + VELAR+A + G +AG +GP+G+ +A Sbjct: 65 FGASRRRLAEY-QAEGRIREINHAGVELARRAAQ---------GKAYIAGDIGPFGSTIA 114 Query: 131 DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA-YPRA 189 + + E R + L +AG DL+A ET+ + E+ A + P Sbjct: 115 PFGD------TTFEEAVGIFREQASILAEAGVDLIAIETMFDIQEMRAALIGVREGAPGV 168 Query: 190 RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVL 248 T G+ V A+L G+ V +G+NC + E L+ L T Sbjct: 169 PIMAFMTYNADGITDSGSDPETVAAVLEGFS-VEIMGLNCSVGPEAMLPVLERLGRATHT 227 Query: 249 PLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 L + PN+G KT + G +++A + P + AGA ++GGCC TTP I + Sbjct: 228 YLGIEPNAGLPVHRDGKTVYPLG--ASEMASFAPAFADAGANIVGGCCGTTPDYIRLI 283 >UniRef50_B3E428 Methionine synthase n=91 Tax=Bacteria RepID=B3E428_GEOLS Length = 1169 Score = 262 bits (671), Expect = 8e-69, Method: Composition-based stats. Identities = 94/324 (29%), Positives = 145/324 (44%), Gaps = 33/324 (10%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREV 54 M+ N L+AL Q IL+LDGAM T+L+AR AD + +++ P++I +V Sbjct: 1 MTNNPVLQAL--SQCILILDGAMGTQLQARNLTAADFGGEAYEGCNEMLVLTRPDVIEDV 58 Query: 55 HLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAG 114 H Y AGA T S+ +T A GL + + L + +ARKA +AY + Sbjct: 59 HKAYLEAGADIVETCSFGSTDIVLAEYGLAD-KVFELNKAAALVARKACDAYSTPD---K 114 Query: 115 TLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFS 174 VAGS+GP ++ + E R + LL G DLL ET + Sbjct: 115 PRFVAGSMGPTTRTISVTG------GVTFEQLVTAFRDQTIGLLAGGVDLLLLETAQDTL 168 Query: 175 EIEALAELLT-----AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQ---VVALG 226 ++A AE + R S T+ + + G + + A L + ++++G Sbjct: 169 NLKAGAEGIRLAFEQTGQRVPLMVSGTIEPTGTMLAGQNVEALYASLTHLEENLGLISIG 228 Query: 227 INC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ 285 +NC E T L+ L L + VYPN+G + + + E LA L ++ Sbjct: 229 LNCATGPEFMTDHLRALSELATCHISVYPNAGLPDENGN-----YAESPDSLAQKLSRFV 283 Query: 286 AAG-ARLIGGCCRTTPADIAALKA 308 G +IGGCC T+PA IAA+ Sbjct: 284 DEGWLNIIGGCCGTSPAHIAAIAN 307 >UniRef50_B6YR37 Cobalamin-dependent methionine synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YR37_AZOPC Length = 1224 Score = 262 bits (671), Expect = 8e-69, Method: Composition-based stats. Identities = 77/327 (23%), Positives = 139/327 (42%), Gaps = 32/327 (9%) Query: 5 NPLRALLDKQDILLLDGAMATELEA--------RGCNLAD---SLW--SAKVLVENPELI 51 N + LL ++ ILLLDG M + ++ RG A ++ S + + P++I Sbjct: 2 NSISQLL-QERILLLDGGMGSMIQNYRLKETDYRGLQFAHLSGEMYGNSDILCITRPDII 60 Query: 52 REVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENP 111 + +H Y AGA T S T A G+ E+ ++L + +A++ + Y P Sbjct: 61 QSIHEAYLEAGADIIETNSMNMTAISMADYGI-ESHVESLNKAAATIAKEVAQKYTKLTP 119 Query: 112 QAGTLLVAGSVGPYGAY--LADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACET 169 VAGS+GP L+ G + + + ++ AL+ G D+L ET Sbjct: 120 D-KPRFVAGSIGPTNKTSSLSPDVNNPGYRNITFTELYKAYCEQIAALIFGGVDILLVET 178 Query: 170 LPNFSEIEALA-----ELLTAYPRARAWFSFTLR-DSEHLSDGTPLRDVVALLAGYPQVV 223 + ++A E+ A S+TL +S + G L V+ + + ++ Sbjct: 179 AFDTLNVKAALMAAEDEMKIAKKELPLMLSYTLSGNSGRILSGQTLEAVLESI-SHINLL 237 Query: 224 ALGINCI-ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLP 282 ++G+NC L+ L + + YPN+G + + E +A+ + Sbjct: 238 SIGLNCSFGARTMKPFLKKLGQIAPCYVSAYPNAGLP-----NAFGKYNETPEMMAEQIR 292 Query: 283 QWQA-AGARLIGGCCRTTPADIAALKA 308 ++ + ++GGCC TTP IAA+ Sbjct: 293 EYIDESLVNIVGGCCGTTPQHIAAIAR 319 >UniRef50_C6DY72 Homocysteine S-methyltransferase n=10 Tax=Desulfuromonadales RepID=C6DY72_GEOSM Length = 813 Score = 262 bits (671), Expect = 9e-69, Method: Composition-based stats. Identities = 81/298 (27%), Positives = 127/298 (42%), Gaps = 23/298 (7%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K+ +L+LDGAM T L+ RG S ++ + E++ VH Y AGA +T ++ Sbjct: 10 KERVLVLDGAMGTMLQERGLKPGQS--PEEMNLTAAEVVAGVHQAYLDAGADIIVTNTFG 67 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 T A GL + Q + ++V +AR+ VAGS+GP G +L Sbjct: 68 GTKAKLEHYGLGD-QVARINAEAVRIAREVA---------GEKAYVAGSIGPTGRFLEPV 117 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY-PRARA 191 + S + + R + +AL+DAG DL++ ET + EI A + Sbjct: 118 GD------MSFDEAVSLFREQAQALVDAGCDLISFETFLDIKEIRAGVIAVREISQEIPV 171 Query: 192 WFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPL 250 T + GTP + L + +G NC + + L + +T LPL Sbjct: 172 IAMLTFEEKGISVLGTPPQAAAITLEAVGATI-VGSNCGLGPDGIYQILSDMRDVTALPL 230 Query: 251 VVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 + N+G T ++ Y + G R+IGGCC TTPA I+A+K Sbjct: 231 ISQANAGLPILKDGVTI--FPATPDEMTAYHDRLIELGVRIIGGCCGTTPAHISAIKK 286 >UniRef50_Q7M929 S-METHYLTRANSFERASE n=1 Tax=Wolinella succinogenes RepID=Q7M929_WOLSU Length = 1120 Score = 262 bits (669), Expect = 1e-68, Method: Composition-based stats. Identities = 70/308 (22%), Positives = 132/308 (42%), Gaps = 27/308 (8%) Query: 11 LDKQDILLLDGAMATELEARGCNLADSLW------SAKVLVENPELIREVHLDYYRAGAQ 64 + +Q +++LDGAM TE++ +L + W S + V ++I +H Y AGA Sbjct: 9 IHRQRVMILDGAMGTEIQK--FDLKEEDWEEKAGCSEILNVTRGDVILSIHRSYLEAGAD 66 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP 124 + ++ A P G+ ++ + ++A++A +++ VAGS+GP Sbjct: 67 ILKSNTFGALPWVLEEYGIG-GRAYEMAFAGAQIAKEACDSF-----APSPRFVAGSLGP 120 Query: 125 YGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 G++ H + ++ L + GADL ET + +I+A Sbjct: 121 -------GTKLPSLGHIDYDTMFEGYKEAARGLKEGGADLFLLETCQDPLQIKAAVHACK 173 Query: 185 AYPRA-RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHL 242 + S T+ + + GT ++ + +L ++ +LGINC + + L+ L Sbjct: 174 EVDSSMPIMVSATIETTGTMLIGTDIKTLAVILEPL-EIFSLGINCGLGPDMAEKHLKAL 232 Query: 243 HGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQA-AGARLIGGCCRTTPA 301 PL ++ N+G + T++ + A+ ++ G +GGCC TTP Sbjct: 233 AQYAPFPLSIHANAGLPQNVGGCTFYPM--EPKEFAEIEEEFLGIEGVAFLGGCCGTTPE 290 Query: 302 DIAALKAR 309 I LK R Sbjct: 291 HIRQLKER 298 >UniRef50_C3XLV5 S-methyltransferase n=2 Tax=Helicobacter RepID=C3XLV5_9HELI Length = 1154 Score = 261 bits (667), Expect = 2e-68, Method: Composition-based stats. Identities = 75/309 (24%), Positives = 135/309 (43%), Gaps = 22/309 (7%) Query: 13 KQDILLLDGAMATELEAR-----GCNLADS---LWSAKVLVENPELIREVHLDYYRAGAQ 64 K+ +L+LDGAM TE++ G N S + + ++I+ +H Y +AGA Sbjct: 8 KERVLILDGAMGTEIQKHNIQTWGVNAKGEKLDGCSEALNLYAKDIIKAIHTSYLQAGAN 67 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP 124 T ++ P A GL+E K + VELA++ + + Q L VA S+GP Sbjct: 68 ILKTNTFGVMPWVLAEYGLEEH-CKEIAKTGVELAKECIKKHSPLKNQNNALFVAASLGP 126 Query: 125 YGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 G++ H + ++ + + VE +A AD++ ET + +I+A + Sbjct: 127 -------GTKLPSLGHITYDSMEEGYALCVEGFKEADADVILLETAQDPLQIKAALNAIK 179 Query: 185 -AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHL 242 P S T+ + + GT + + +L Y +++LGINC + + L L Sbjct: 180 NTAPEIPIMVSVTIETTGTMLIGTDITTLFHILEPY-DLLSLGINCGLGPDLAHKHLVTL 238 Query: 243 HGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAA-GARLIGGCCRTTPA 301 + P+ ++ N+G + T++ + + + G +GGCC TTP Sbjct: 239 SEVCKFPISIHTNAGLPENRGGVTYYPMD--AEEFSTIEKSFLEIPGVAFLGGCCGTTPE 296 Query: 302 DIAALKARS 310 I L ++ Sbjct: 297 HIRQLVQKT 305 >UniRef50_C6JIG3 Methionine synthase n=3 Tax=Fusobacterium RepID=C6JIG3_FUSVA Length = 1112 Score = 260 bits (666), Expect = 3e-68, Method: Composition-based stats. Identities = 66/308 (21%), Positives = 125/308 (40%), Gaps = 21/308 (6%) Query: 13 KQDILLLDGAMATELEARGCNLADSL----WSAKVLVENPELIREVHLDYYRAGAQCAIT 68 K+ IL+LDGA T ++ + D + + + P++I+E+H Y +AGA T Sbjct: 6 KKRILVLDGATGTAIQKYNLSEIDFQGKKGCNEILNISRPDIIKEIHTGYIKAGADIIET 65 Query: 69 ASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 S+ G+ E S L K ELAR+ + + + VAGS+GP Sbjct: 66 NSFNCNRISLKDYGI-EDMSYTLSKKGAELAREIADNFY--KTSGKKIYVAGSIGPTSKS 122 Query: 129 LA-DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYP 187 L+ + + + + + + ++E ++D GAD + ET+ + +A Sbjct: 123 LSLPVGDNPYERELNFDQMKNIYSEQIEGVIDGGADCILIETIFDGLNAKAALIAAEELF 182 Query: 188 RA-----RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQH 241 S T+ + G + ++ L P +++ G+NC ++ ++ Sbjct: 183 EKKNIQLPIMISATVNKQGKIFSGQSIESLIVAL-DRPSIISFGLNCSFGAKDLIPMIKK 241 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG-ARLIGGCCRTTP 300 + T + +YPN+G + + E YL + ++GGCC T Sbjct: 242 IAAFTDKYISLYPNAGLPNENG-----EYEETPEITTGYLKELVDKKQVNILGGCCGTHF 296 Query: 301 ADIAALKA 308 + I A+ Sbjct: 297 SHIKAIAD 304 >UniRef50_D1BQ67 Homocysteine S-methyltransferase n=4 Tax=Veillonellaceae RepID=D1BQ67_VEIPT Length = 811 Score = 260 bits (666), Expect = 3e-68, Method: Composition-based stats. Identities = 67/298 (22%), Positives = 121/298 (40%), Gaps = 27/298 (9%) Query: 18 LLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPAG 77 + DGAM T L+A G + VE PE+++ +H Y + G+ T ++ A Sbjct: 3 IFDGAMGTMLQAAGLE--EGYCPELFNVERPEVVKNIHAQYLQHGSDVITTNTFGACGLK 60 Query: 78 FAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYRG 137 L + + + + +V++A++A + +AGS+GP G +L Sbjct: 61 LEDYDLQD-RVREINIAAVKVAKEAIAEVKP------SARIAGSMGPTGRFLQPLG---- 109 Query: 138 DYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA--------ELLTAYPRA 189 + S + +R + EAL++ G D + ET+ + E+ A Sbjct: 110 --NMSFDDIYDTYREQAEALIEGGVDFIIIETIIDVQEMRAALLASLDAREAAGKTKEDV 167 Query: 190 RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVL 248 + F+ + GTP +++ +GINC E T ++ + +T L Sbjct: 168 QIICQFSFSEDGRTITGTPPAVATSIVEAI-GADIIGINCSLGPEQITPLIKEIASVTNL 226 Query: 249 PLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 P+ PN+G +T ++ + AG +GGCC TTPA I ++ Sbjct: 227 PISCQPNAGMPQLINKQTV--FPLTAEEMGPLMLDIVDAGTSYVGGCCGTTPAHIQSI 282 >UniRef50_C7NB07 Methionine synthase n=6 Tax=Leptotrichia RepID=C7NB07_LEPBD Length = 1169 Score = 260 bits (666), Expect = 3e-68, Method: Composition-based stats. Identities = 75/310 (24%), Positives = 128/310 (41%), Gaps = 24/310 (7%) Query: 13 KQDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREVHLDYYRAGAQCA 66 K ILLLDGAM T ++ D + ++++ P++I+ +H Y AG+ Sbjct: 18 KNKILLLDGAMGTMIQQENLTADDFGGEKYEGCNDYLVLQRPDVIKNIHKKYLEAGSDII 77 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQ-AGTLLVAGSVGPY 125 T S+ A L E + K+ EL +A Y +E+P+ L VAG++GP Sbjct: 78 ETNSFGALDIVLKDYDL-EDTVFEMNKKAAELVNEAIAEYRSEHPEVTRNLYVAGALGPS 136 Query: 126 GAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA----LAE 181 ++ + E + V L+ G DL+ ET+ + ++A L + Sbjct: 137 NKSISVTG------GVTFEELIHTYYTAVSGLMAGGVDLILFETIQDTRNLKAAYLGLKK 190 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQ 240 + SFT+ + G D + ++G+NC E T L+ Sbjct: 191 AMEENYTVPLMLSFTIESTGTTLAGQT-ADAFYYAVNHMNPFSVGLNCATGPEFMTQFLK 249 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 L+ ++ + VYPN+G + + + A P +Q ++GGCC TTP Sbjct: 250 TLNNISNTYISVYPNAGLP--NEDGEYEETPDTLS--AKIEPFFQNNYLNIVGGCCGTTP 305 Query: 301 ADIAALKARS 310 I +K +S Sbjct: 306 EHIQKIKEKS 315 >UniRef50_A9B657 Methylenetetrahydrofolate reductase n=1 Tax=Herpetosiphon aurantiacus ATCC 23779 RepID=A9B657_HERA2 Length = 617 Score = 260 bits (666), Expect = 3e-68, Method: Composition-based stats. Identities = 77/307 (25%), Positives = 126/307 (41%), Gaps = 22/307 (7%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 NP L Q LL DGAM T+L RG + + + + P+++RE+H Y AGA Sbjct: 3 NPFLEQLG-QRALLCDGAMGTQLYGRGIDFDECF--DALNLTQPDVVREIHQSYIEAGAD 59 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP 124 T +Y A GL + + + + + ++LAR+ARE L+AG+VGP Sbjct: 60 IIETNTYGANRFKLEPFGLAD-KVRQINHRGMKLAREAREI------AGTNTLIAGAVGP 112 Query: 125 YGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 G L +A ++ LL+ GADLL ET + E+ + Sbjct: 113 LGVLLQPYGPLT------EQAAHEAFAEQIGTLLEQGADLLMFETFSDLREMLIAVKAAK 166 Query: 185 AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLH 243 T + G +VV L V +G+NC + + +Q + Sbjct: 167 QVGDLPIVAQMTFAEDGRTVLGNTPEEVVRKLVEL-GVAVVGVNCSVGSQRVFRVVQSMR 225 Query: 244 GLTV-LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ-AAGARLIGGCCRTTPA 301 + +P+ PN+G + + +ADY + +++GGCC TTP Sbjct: 226 AVNPTIPISAQPNAG--WPTERHNRVFYPSSPEYMADYARRMVEELNVQIVGGCCGTTPQ 283 Query: 302 DIAALKA 308 I+ + + Sbjct: 284 HISNMHS 290 >UniRef50_C1XT53 Methionine synthase (B12-dependent) n=2 Tax=Meiothermus RepID=C1XT53_9DEIN Length = 1223 Score = 260 bits (666), Expect = 3e-68, Method: Composition-based stats. Identities = 69/307 (22%), Positives = 117/307 (38%), Gaps = 27/307 (8%) Query: 14 QDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREVHLDYYRAGAQCAI 67 + +L+ DGAM TE+ + AD + + P++I +H Y AGA Sbjct: 23 ERVLIYDGAMGTEIFKYDLSAADYGAEQYNGCPEMLNRTRPDVIEAIHKSYLEAGADVIE 82 Query: 68 TASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGA 127 T ++ A P GL EA++ L LAR+ + + + VAGS+GP Sbjct: 83 TNTFGAFPHVLVEYGL-EAEAYELAFAGAHLARRVADEHSTPD---QPRFVAGSMGPGTK 138 Query: 128 YLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY- 186 ++ G S E +R + LLD G DL+ ET + ++ Sbjct: 139 LISLGQ-------ISWEGLFESYRVCAQGLLDGGVDLILIETCQDILQVRCAVLAARRAM 191 Query: 187 ----PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 T+ + + GT + +L P + +G NC + ++ Sbjct: 192 KDVGREVPIQVQVTMETTGTMLVGTDDAAALTVLEALP-IDVVGFNCATGPDLMDTHVRF 250 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ-AAGARLIGGCCRTTP 300 + PN+G + + + A+LA + ++ G ++GGCC T P Sbjct: 251 FCENATRWVSCLPNAGLPRNEGGRVV--YDLTPAELARWQQKFVNEYGLNVVGGCCGTGP 308 Query: 301 ADIAALK 307 I AL Sbjct: 309 EHIRALA 315 >UniRef50_UPI00017B4C9F UPI00017B4C9F related cluster n=1 Tax=Tetraodon nigroviridis RepID=UPI00017B4C9F Length = 1141 Score = 260 bits (664), Expect = 5e-68, Method: Composition-based stats. Identities = 78/325 (24%), Positives = 139/325 (42%), Gaps = 30/325 (9%) Query: 7 LRALLDKQDILLLDGAMATELEA--------RGCNLAD---SLW--SAKVLVENPELIRE 53 LR +L+ + I++LDG M T ++ RG D L + + + P+++ + Sbjct: 19 LRGILE-RRIMILDGGMGTMIQQHKLEECNFRGDEFKDHPQPLMGNNDLLSLTCPDIVYK 77 Query: 54 VHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQA 113 +H DY AGA T ++ T A GL E + L S ELARKA + + Sbjct: 78 IHKDYLLAGADIIETNTFSGTSVAQADYGL-EHMAYRLNKASAELARKAADDVTS--STG 134 Query: 114 GTLLVAGSVGPYGAYL--ADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLP 171 VAG++GP L + E + + +A + +V+ LLD G D+L ET+ Sbjct: 135 VKRYVAGALGPTNKTLSVSPSVEKPHFRNITFDALVEAYTEQVKGLLDGGVDILLVETIF 194 Query: 172 NFSEIEALAELL-----TAYPRARAWFSFTLRD-SEHLSDGTPLRDVVALLAGYPQVVAL 225 + + +A + +Y R + S T+ D S G + + + + + + + Sbjct: 195 DTANAKAALFAIDLLFEKSYSRKPIFISGTVVDRSGRTLSGQTV-EAFVVSVSHAKPLCI 253 Query: 226 GINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW 284 G+NC + ++ + T ++ YPN+G + + ++ ++ Sbjct: 254 GLNCALGATEMRPFIEAIGKCTTAFVICYPNAGNPHLF--NQYLSDTVRPTHISFNAKEF 311 Query: 285 QAAG-ARLIGGCCRTTPADIAALKA 308 G ++GGCC TTP I AL Sbjct: 312 SVDGLVNIVGGCCGTTPEHIRALCE 336 >UniRef50_Q01YW7 Methionine synthase (B12-dependent) n=5 Tax=Bacteria RepID=Q01YW7_SOLUE Length = 1185 Score = 259 bits (663), Expect = 7e-68, Method: Composition-based stats. Identities = 72/307 (23%), Positives = 131/307 (42%), Gaps = 28/307 (9%) Query: 13 KQDILLLDGAMATELEARGCNLADSL-----WSAKVLVENPELIREVHLDYYRAGAQCAI 67 +Q +L+LDGAM T + ++ + V P++I+++H Y AGA Sbjct: 16 EQRVLVLDGAMGTMIHQAPLSIETDYLGRENCPEILNVTRPDVIQDIHRQYLEAGADIIE 75 Query: 68 TASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGA 127 T ++ T A L+E ++ L + +LAR+ + + + A VAGS+GP Sbjct: 76 TNTFGGTRIALADNKLEE-RAYELNFAAAKLAREVADQF---STAAKPRFVAGSIGPTNK 131 Query: 128 YLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYP 187 L + +A + + + L++ GAD L ET + ++A + Sbjct: 132 DLNITGS------TTFPEIKAAYYEQAKGLVEGGADYLLIETCFDTGSLKAGLVAVEQLG 185 Query: 188 R-----ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 R S T+ + + G + + A + + +++ +G+NC + T ++ Sbjct: 186 RELAIQIPVVASVTIERTGTMLGGQQIDALYASIGNH-ELLGVGMNCATGPDLMTDHIRT 244 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG-ARLIGGCCRTTP 300 L+ ++ + YPN+G GE LA L ++ G +GGCC TTP Sbjct: 245 LNEMSAHRISCYPNAGLP-----NAEGKFGETPDSLAAQLEKFANQGWLNFVGGCCGTTP 299 Query: 301 ADIAALK 307 A I A+ Sbjct: 300 AHIQAIA 306 >UniRef50_UPI000180BE5F PREDICTED: similar to CG10623 CG10623-PA n=1 Tax=Ciona intestinalis RepID=UPI000180BE5F Length = 305 Score = 259 bits (662), Expect = 9e-68, Method: Composition-based stats. Identities = 105/305 (34%), Positives = 156/305 (51%), Gaps = 23/305 (7%) Query: 14 QDILLLDGAMATELEARGCNL-----ADSLWSAKVLVENPELIREVHLDYYRAGAQCAIT 68 +DI +LDG + T+L G + D LWSA+VL E PE I + HL + +AG+ T Sbjct: 2 EDIKILDGGLCTDLFINGGFVRAEVNKDPLWSARVLYEKPEEIMKAHLRFIKAGSDVVST 61 Query: 69 ASYQATPAGFAARG-LDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGA 127 SYQA+ G+ + + +++ +IG SV++A++A + +LVAGS+ PYGA Sbjct: 62 CSYQASVQGYMEHAQVTKEKAEKIIGSSVDVAKQAVQE------SGRRVLVAGSISPYGA 115 Query: 128 YLADGSEYRGDY--HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA 185 L D SEY G Y S + FH+ + L G DL A ETLP+ E LAE+L Sbjct: 116 ILHDMSEYTGSYIDTTSEQQLSDFHKTNIRILASKGVDLFAFETLPSLKEALVLAEILRE 175 Query: 186 YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL 245 YP +AW SF+ ++ H G P +V L Y Q++A+G+NC E ++ +Q HG Sbjct: 176 YPTLKAWVSFSNKNGTHTCYGEPFEEVFKALGNYHQIIAIGLNCCKSETISSFIQLAHGN 235 Query: 246 TVLP--LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGAR-LIGGCCRTTPAD 302 L++YPN+ + S E + + W + IGGCC T+P Sbjct: 236 LAKHQRLIIYPNNCAGGNVNS------SEAPLEWLPKVKTWLESNLIGWIGGCCMTSPFQ 289 Query: 303 IAALK 307 I +K Sbjct: 290 IGQIK 294 >UniRef50_B4DST3 cDNA FLJ56487, highly similar to Methionine synthase (EC 2.1.1.13) n=1 Tax=Homo sapiens RepID=B4DST3_HUMAN Length = 1118 Score = 259 bits (661), Expect = 1e-67, Method: Composition-based stats. Identities = 79/331 (23%), Positives = 141/331 (42%), Gaps = 35/331 (10%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEA--------RGCNLADSLWSAK-----VLVENP 48 + + + A+L K I++LDG M T ++ RG D K + + P Sbjct: 17 TLRDEINAILQK-RIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQP 75 Query: 49 ELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLA 108 ++I ++H +Y AGA T ++ +T A GL E + + S +ARKA E Sbjct: 76 DVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGL-EHLAYRMNMCSAGVARKAAEEVTL 134 Query: 109 ENPQAGTLLVAGSVGPYGAYL--ADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLA 166 + VAG++GP L + E + + + ++ + + LLD G D+L Sbjct: 135 Q--TGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILL 192 Query: 167 CETLPNFSEIEALAELLT-----AYPRARAWFSFTLRD--SEHLSDGTPLRDVVALLAGY 219 ET+ + + +A L Y + S T+ D LS T V+++ G Sbjct: 193 IETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGE 252 Query: 220 PQVVALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLA 278 P + +G+NC + ++ + T ++ YPN+G T+ + E + +A Sbjct: 253 P--LCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLP-----NTFGDYDETPSMMA 305 Query: 279 DYLPQWQAAG-ARLIGGCCRTTPADIAALKA 308 +L + G ++GGCC +TP I + Sbjct: 306 KHLKDFAMDGLVNIVGGCCGSTPDHIREIAE 336 >UniRef50_Q6BZK6 DEHA2A00616p n=1 Tax=Debaryomyces hansenii RepID=Q6BZK6_DEBHA Length = 351 Score = 259 bits (661), Expect = 1e-67, Method: Composition-based stats. Identities = 102/343 (29%), Positives = 163/343 (47%), Gaps = 38/343 (11%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNL---------ADSLWSAKVLVENPELIRE 53 N + L++ + L++DGA+ T+LE + L LWSA VL++NPELI+E Sbjct: 1 MINDINTLINTKP-LVIDGALGTQLETKFSKLLQQDNINIQTHPLWSALVLLKNPELIQE 59 Query: 54 VHLDYYRAGAQCAITASYQATPAGFAAR--GLD-EAQSKALIGKSVELARKAREAYLAEN 110 VH DY +GA T++YQA+ G G++ + + A+ K++ELA AR YL Sbjct: 60 VHYDYMCSGANIITTSTYQASKRGLLEYAPGIENDDEVNAVYDKAIELAVDARSQYLENM 119 Query: 111 PQA------GTLLVAGSVGPYGAYLADGSEYRGDYH---CSVEAFQAFHRPRVEALL-DA 160 + + + GS+GP+GAYLA+G+EY G Y + + FH + + Sbjct: 120 GKGMNTLTNKEIFICGSIGPFGAYLANGAEYTGKYGSHITEPQELKKFHYDITSQFISNP 179 Query: 161 GADLLACETLPNFSEIEALAELLTAY---PRARAWFSFTLRDSEHLSDGTPLRDVVALLA 217 D++ ET+PN+SE + + L+ + S +D + + DGTP+ VV L Sbjct: 180 KCDIIGFETIPNYSEFQQIVHLMEELLQKTNKPFYISLNFKDPKTICDGTPITQVVDYLN 239 Query: 218 G--------YPQVVALGINCIALENTTAALQHLHGLTVL---PLVVYPNSGEHYDAVSKT 266 + LG NC+ LE T L ++ L + PL+ YPN+G +YD Sbjct: 240 ERLSNNEKLRSAFIGLGCNCVPLEIATNILLNMSDLNNVHRFPLIAYPNAGLNYDLSKGE 299 Query: 267 WHHHGEHCAQLADYLPQWQA-AGARLIGGCCRTTPADIAALKA 308 + D +W RL+G CC + P +I ++ Sbjct: 300 YSIKSSEKQVWEDSCREWLEKLNVRLVGACCGSGPDEILTIRE 342 >UniRef50_Q99707 Methionine synthase n=289 Tax=cellular organisms RepID=METH_HUMAN Length = 1265 Score = 259 bits (661), Expect = 1e-67, Method: Composition-based stats. Identities = 79/331 (23%), Positives = 141/331 (42%), Gaps = 35/331 (10%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEA--------RGCNLADSLWSAK-----VLVENP 48 + + + A+L K I++LDG M T ++ RG D K + + P Sbjct: 17 TLRDEINAILQK-RIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQP 75 Query: 49 ELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLA 108 ++I ++H +Y AGA T ++ +T A GL E + + S +ARKA E Sbjct: 76 DVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGL-EHLAYRMNMCSAGVARKAAEEVTL 134 Query: 109 ENPQAGTLLVAGSVGPYGAYL--ADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLA 166 + VAG++GP L + E + + + ++ + + LLD G D+L Sbjct: 135 Q--TGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILL 192 Query: 167 CETLPNFSEIEALAELLT-----AYPRARAWFSFTLRD--SEHLSDGTPLRDVVALLAGY 219 ET+ + + +A L Y + S T+ D LS T V+++ G Sbjct: 193 IETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGE 252 Query: 220 PQVVALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLA 278 P + +G+NC + ++ + T ++ YPN+G T+ + E + +A Sbjct: 253 P--LCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLP-----NTFGDYDETPSMMA 305 Query: 279 DYLPQWQAAG-ARLIGGCCRTTPADIAALKA 308 +L + G ++GGCC +TP I + Sbjct: 306 KHLKDFAMDGLVNIVGGCCGSTPDHIREIAE 336 >UniRef50_B7ZLW7 MTR protein n=1 Tax=Homo sapiens RepID=B7ZLW7_HUMAN Length = 1214 Score = 258 bits (660), Expect = 1e-67, Method: Composition-based stats. Identities = 79/331 (23%), Positives = 141/331 (42%), Gaps = 35/331 (10%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEA--------RGCNLADSLWSAK-----VLVENP 48 + + + A+L K I++LDG M T ++ RG D K + + P Sbjct: 17 TLRDEINAILQK-RIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQP 75 Query: 49 ELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLA 108 ++I ++H +Y AGA T ++ +T A GL E + + S +ARKA E Sbjct: 76 DVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGL-EHLAYRMNMCSAGVARKAAEEVTL 134 Query: 109 ENPQAGTLLVAGSVGPYGAYL--ADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLA 166 + VAG++GP L + E + + + ++ + + LLD G D+L Sbjct: 135 Q--TGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILL 192 Query: 167 CETLPNFSEIEALAELLT-----AYPRARAWFSFTLRD--SEHLSDGTPLRDVVALLAGY 219 ET+ + + +A L Y + S T+ D LS T V+++ G Sbjct: 193 IETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGE 252 Query: 220 PQVVALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLA 278 P + +G+NC + ++ + T ++ YPN+G T+ + E + +A Sbjct: 253 P--LCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLP-----NTFGDYDETPSMMA 305 Query: 279 DYLPQWQAAG-ARLIGGCCRTTPADIAALKA 308 +L + G ++GGCC +TP I + Sbjct: 306 KHLKDFAMDGLVNIVGGCCGSTPDHIREIAE 336 >UniRef50_C6D4G9 Methylenetetrahydrofolate reductase n=12 Tax=cellular organisms RepID=C6D4G9_PAESJ Length = 632 Score = 257 bits (657), Expect = 3e-67, Method: Composition-based stats. Identities = 82/297 (27%), Positives = 118/297 (39%), Gaps = 24/297 (8%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 KQ IL DGAM T L G + S ++ + P++I VH YY AGA+ T ++ Sbjct: 10 KQRILTGDGAMGTYLYQMGFPVGVSY--EELNMTRPDVIEGVHRRYYEAGARVIETNTFS 67 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A + GL E +A+ V +A+ A V G+VG A Sbjct: 68 ANLVKLSKYGL-EPDMEAINRAGVRIAKAAA---------GEDAYVVGAVGSIRA----- 112 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 +++ALL G D + ET +F E+ L + Sbjct: 113 ---GKLKDVRTSEVSHAFERQLDALLVEGVDGILFETFYDFDEMRLALGLARKLTQLPVI 169 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLV 251 F +D DGT L D LL +G NC A++ + G LPL Sbjct: 170 CQFAAQDVGRTQDGTGLLDAFTLLKD-EGADVVGFNCRSGPNGIMRAVESIGGPVELPLS 228 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 ++PN+G K + + A+ Q+ GAR+IGGCC TTP IAA+ Sbjct: 229 IFPNAGIPDYVDGK--YKYSAGPDYFAETALQFADRGARIIGGCCGTTPEHIAAMAK 283 >UniRef50_C6W4B8 Methionine synthase n=4 Tax=Bacteria RepID=C6W4B8_DYAFD Length = 1274 Score = 257 bits (657), Expect = 4e-67, Method: Composition-based stats. Identities = 81/347 (23%), Positives = 138/347 (39%), Gaps = 51/347 (14%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEA--------RGCNLADSLW-------SAKVLVE 46 +Q +R +L K IL+LDGAM T ++ RG AD W + + + Sbjct: 4 TQKADIREIL-KNRILVLDGAMGTMIQRYKLQDHDYRGERFAD--WPHDVKGNNDLLSLT 60 Query: 47 NPELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAY 106 P++I+E+H Y+ AGA A T ++ T A G++E L +S LAR+ + + Sbjct: 61 RPDIIKEIHAAYFAAGADIAETNTFSGTTIAMADYGMEEI-VYELNYESARLAREVADEF 119 Query: 107 LAENPQAGTLLVAGSVGPYG--AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADL 164 P VAGS+GP A L+ G S + + +V+ L D G DL Sbjct: 120 TEREP-HKPRFVAGSIGPTNRTASLSPDVNNPGFRAISFDQLVEAYYEQVKGLTDGGCDL 178 Query: 165 LACETLPNFSEIEALAELLTAY--------------------PRARAWFSFTLRD-SEHL 203 L ET+ + +A + + S T+ D S Sbjct: 179 LLVETIFDTLNAKAALFAIDQFFADAKAGKVEHLESWRIEPGQALPIMISGTITDASGRT 238 Query: 204 SDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDA 262 G + ++ P ++++G+NC + + +Q + + +PN+G + Sbjct: 239 LSGQTTEAFLTSVSHLP-LLSVGLNCALGADLMRPYVQIMAKESPFYTSAHPNAGLPNEM 297 Query: 263 VSKTWHHHGEHCAQLADYLPQWQAAG-ARLIGGCCRTTPADIAALKA 308 + E Q+ + + + +IGGCC TTP I + Sbjct: 298 G-----EYDETPEQMGEVIDGFLRDNLVNIIGGCCGTTPDHIRVIAE 339 >UniRef50_Q5SKM5 5-methyltetrahydrofolate homocysteine S-methyltransferase n=5 Tax=Bacteria RepID=Q5SKM5_THET8 Length = 1185 Score = 255 bits (653), Expect = 1e-66, Method: Composition-based stats. Identities = 77/315 (24%), Positives = 131/315 (41%), Gaps = 34/315 (10%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREVHLDYYR 60 L+ALL + L+ DGAM TEL+ R D + PE++RE+HL Y Sbjct: 42 LKALL--ERPLVFDGAMGTELQKRDLTPEDYGGEAYFGCPEVLNRTRPEVVREIHLAYLE 99 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGA+ T ++ A A GL+EA ++ L +AR+A + + A VAG Sbjct: 100 AGAEVIETNTFGALRHVLAEYGLEEA-AEELAFLGARIAREAADPHGA--------FVAG 150 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE--- 177 ++GP ++ G S +A ++ LL G DL+ ET + ++ Sbjct: 151 ALGPGTKLVSLGQ-------ISWDALYRAYKEAARGLLKGGVDLILLETAQDILQVRCAV 203 Query: 178 -ALAELLTAYPR-ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALEN 234 A+ E + R T + + GT + +A L P V +G+NC + Sbjct: 204 LAVREAMAEVGREVPLQVQVTFEATGTMLVGTDEQAALAALESLP-VDVVGMNCATGPDL 262 Query: 235 TTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ-AAGARLIG 293 + +++ + + PN+G + + + +LA + ++ G +G Sbjct: 263 MDSKVRYFAEHSTRFVSCLPNAGLPRNEGGRVV--YDLTPEELAKWHLKFVAEYGVNAVG 320 Query: 294 GCCRTTPADIAALKA 308 GCC T P I + Sbjct: 321 GCCGTGPEHIRKVAE 335 >UniRef50_UPI0001BC43AA B12-dependent methionine synthase n=1 Tax=Fusobacterium ulcerans ATCC 49185 RepID=UPI0001BC43AA Length = 1113 Score = 255 bits (652), Expect = 1e-66, Method: Composition-based stats. Identities = 62/307 (20%), Positives = 121/307 (39%), Gaps = 19/307 (6%) Query: 13 KQDILLLDGAMATELEARGCNLADSL----WSAKVLVENPELIREVHLDYYRAGAQCAIT 68 K+ +L+LDGA T ++ D + + + P++I+E+H Y AGA T Sbjct: 6 KKRVLVLDGATGTAIQKYNLTDEDFQGKKGCNEILNITRPDVIKEIHTKYIEAGADIIET 65 Query: 69 ASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 S+ + E S L K ELAR+ + + + VAGS+GP Sbjct: 66 NSFNCNRISLKDYEI-EDMSYTLSKKGAELARETADNFY--KTSGKKIYVAGSIGPTSKS 122 Query: 129 LA-DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYP 187 L+ + + + + + + ++E ++D G D L ET+ + +A Sbjct: 123 LSLPMGDVPYEREINFDQMKKIYSEQIEGVIDGGVDCLLIETIFDGLSAKAALVAAEELF 182 Query: 188 RA-----RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQH 241 S T+ + G + ++ L P +++ G+NC + ++ Sbjct: 183 EKKNIQLPIMISATVNRQGKIFSGQSIESLITAL-DRPSIISFGLNCSFGARDLIPMIKR 241 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 + T + +YPN+G + + L + + + + ++GGCC T + Sbjct: 242 IASFTDKYISLYPNAGLP-NEEGEYEETPEITAGYLKELVDEKK---VNILGGCCGTHFS 297 Query: 302 DIAALKA 308 I A+ Sbjct: 298 HIKAIAD 304 >UniRef50_C0ZBM1 5-methyltetrahydrofolate--homocysteine methyltransferase n=3 Tax=Bacillales RepID=C0ZBM1_BREBN Length = 1148 Score = 255 bits (652), Expect = 1e-66, Method: Composition-based stats. Identities = 75/319 (23%), Positives = 124/319 (38%), Gaps = 30/319 (9%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREVHL 56 R L ++ IL+LDGAM T L+ D + + + P++IR +H Sbjct: 1 MKPTFREQLSRK-ILILDGAMGTMLQQANLTADDFGGEAYDGCNELLNLTRPDVIRSIHE 59 Query: 57 DYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTL 116 Y AGA T ++ A A + E + + LAR+A +AY E Sbjct: 60 KYLEAGADIVETNTFGAASIVLAEYDVAEKDL-EINIAAARLAREAVDAYSTEEW---PR 115 Query: 117 LVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEI 176 VAG++GP L+ + E + + + L+ G+D+L ET + + Sbjct: 116 FVAGAMGPTTKTLSLTG------GVTFEELVEAYYRQAKGLILGGSDVLLLETSQDTLNV 169 Query: 177 EA----LAELLTAYP-RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-I 230 +A + + S T+ G + L + + V++G+NC Sbjct: 170 KAGGIGIRKAFEELGQEIPVMLSGTIEPMGTTLAGQNIEAFYISLE-HIKPVSIGLNCAT 228 Query: 231 ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG-A 289 E L+ L G+ + YPN+G + H+ E LA + + G Sbjct: 229 GPEFMRDHLRTLSGIAQCAVSCYPNAGLPDENG-----HYHETPQGLASKMRAFAEQGWI 283 Query: 290 RLIGGCCRTTPADIAALKA 308 + GGCC TTP I A+ Sbjct: 284 NVAGGCCGTTPDHIQAMAE 302 >UniRef50_A9KSG0 Homocysteine S-methyltransferase n=7 Tax=Clostridiales RepID=A9KSG0_CLOPH Length = 841 Score = 255 bits (651), Expect = 2e-66, Method: Composition-based stats. Identities = 66/309 (21%), Positives = 129/309 (41%), Gaps = 15/309 (4%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M++N +A+++ Q I++LDGA + L+ G + +++N E++ + +Y Sbjct: 1 MTKNE-FKAMIE-QKIVILDGATGSNLQNAGMP--SGVCPETWILDNKEVLITLQKEYLY 56 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AG ++ + + GL E + + + VEL+++A YL E + ++++AG Sbjct: 57 AGTDILYAPTFTSNRIKLSEYGL-EHRIEEINHSLVELSKEAINRYLEETGETRSIMIAG 115 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 + G L + E ++ ++ L+ +G DLL ET+ + E A Sbjct: 116 DLTMTGEQLLPFGK------MDFEELITIYKEQIGHLVSSGVDLLVVETMLSLQECRAAV 169 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAAL 239 S T + GT + + +L A+G+NC + + + Sbjct: 170 IAAKEICELPVMVSLTFGEDNRTLYGTDPKTAMIVLQSL-GADAVGVNCSSGPKKLSEVI 228 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 + + + +PL+ PN+G +T + A + G ++GGCC TT Sbjct: 229 EQMLPVANVPLIAKPNAGLPKLVEDRTVFTMD--ADEFAASCKIFLELGVSILGGCCGTT 286 Query: 300 PADIAALKA 308 P I L Sbjct: 287 PKHINLLNE 295 >UniRef50_A5DCB0 Putative uncharacterized protein n=2 Tax=Pichia guilliermondii RepID=A5DCB0_PICGU Length = 313 Score = 254 bits (650), Expect = 2e-66, Method: Composition-based stats. Identities = 90/317 (28%), Positives = 154/317 (48%), Gaps = 36/317 (11%) Query: 15 DILLLDGAMATELE----ARGCNLA-DSLWSAKVLVENPELIREVHLDYYRAGAQCAITA 69 L+LDG + +LE R + D LWS + L+E P+LI +VH + AG T+ Sbjct: 5 KPLVLDGGLGIQLETLAEKRNFAVKNDPLWSGRALIEAPDLIEDVHKSFLEAGCDIVTTS 64 Query: 70 SYQATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 +YQ + A +AQ + L KSV++ +A + + + V G++GPYG + Sbjct: 65 TYQISRASLKKYTDFTDAQIEELWAKSVDVCWQACKFHES------KARVCGAIGPYGGF 118 Query: 129 LADGSEYRGDYH-CSVEAFQAFHRPRVEAL-LDAGADLLACETLPNFSEIEALAELLTAY 186 LA+ +EY G+Y + + +H P L + D+LA ET+PN+ E++ + L+ Sbjct: 119 LANYAEYTGEYGLITNHKLEQYHLPLATFLNNNPKVDILAFETIPNYKELKVIVNLVCKM 178 Query: 187 ----PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQ--------VVALGINCIALEN 234 P + S R+S +SDGTP+ ++ L G ++A+G NC L++ Sbjct: 179 SATGPLKPFYLSMNFRNSSQMSDGTPIEKIMGYLNGKLNKNRTLRKRLIAIGCNCTELKD 238 Query: 235 TTAALQHLHGLT--VLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLI 292 T L+++ +P +VYPN ++ + + + + +W GA +I Sbjct: 239 ATHVLKNIETYNYHNIPTIVYPNVFADHN--------DTKIDQKWSQSVDEWLKIGASII 290 Query: 293 GGCCRTTPADIAALKAR 309 GGCC T P IA ++ + Sbjct: 291 GGCCGTGPKQIAQIRFK 307 >UniRef50_B9XKW8 Methylenetetrahydrofolate reductase n=1 Tax=bacterium Ellin514 RepID=B9XKW8_9BACT Length = 624 Score = 254 bits (650), Expect = 2e-66, Method: Composition-based stats. Identities = 82/297 (27%), Positives = 125/297 (42%), Gaps = 24/297 (8%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 Q +LL DGA+ T L RG L S + +++PE++ ++H DY AGA T ++ Sbjct: 9 NQGVLLGDGAIGTLLYQRGQPLNASY--DALNLQHPEIVSQLHRDYLDAGAHLIETNTFG 66 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A GL + + +LA + VAGSVGP A + Sbjct: 67 ANRIKLEKFGLAQKTV-DINKHGAQLALEVA--------CGRGAFVAGSVGPLSADPSSL 117 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 S D + +R ++EAL+ G D L ET E+ + + + Sbjct: 118 STQTKD---------SAYREQLEALVSEGVDALFLETFNRLDELAFVLRIARSLGNTPII 168 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLV 251 S + D H +DG + + + L +G+NC L+ L + Sbjct: 169 ASLSFGDDGHTADGLRINEAFSRLKE-AGADVVGLNCHFGPTIAEKLLEELIVRPGDLIS 227 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 +YPN+G Y + +H + AD+ P+ A GARLIGGCC TTP IAA+ Sbjct: 228 IYPNAGRPYFYEGRYIYHS--TPSYFADFAPKLIAQGARLIGGCCGTTPETIAAMAR 282 >UniRef50_Q5E814 Methionine synthase n=458 Tax=Bacteria RepID=METH_VIBF1 Length = 1226 Score = 253 bits (647), Expect = 5e-66, Method: Composition-based stats. Identities = 72/333 (21%), Positives = 142/333 (42%), Gaps = 35/333 (10%) Query: 1 MSQNNPLRALLDKQ---DILLLDGAMATELEARGCNLAD------SLW-------SAKVL 44 M+ +N ++ ++KQ ILL+DG M T ++ D + W + ++ Sbjct: 1 MAGSN-IKVQIEKQLSERILLIDGGMGTMIQGYKFEEEDYRGERFNKWHCDLKGNNDLLV 59 Query: 45 VENPELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKARE 104 + P++IR++H Y AGA T ++ AT A + E+ S+ + ++ +LAR+ + Sbjct: 60 LSQPQIIRDIHEAYLEAGADILETNTFNATTIAMADYDM-ESLSEEINFEAAKLAREVAD 118 Query: 105 AYLAENPQAGTLLVAGSVGPYGAY--LADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGA 162 + + P VAG +GP ++ G + S + + AL+ G+ Sbjct: 119 KWTEKTPN-KPRYVAGVLGPTNRTCSISPDVNDPGFRNVSFDELVEAYSESTRALIRGGS 177 Query: 163 DLLACETLPNFSEIEALAELLTAYPR-----ARAWFSFTLRD-SEHLSDGTPLRDVVALL 216 DL+ ET+ + +A + + + S T+ D S G L Sbjct: 178 DLILIETIFDTLNAKACSFAVESVFEELDITLPVMISGTITDASGRTLSGQTTEAFYNAL 237 Query: 217 AGYPQVVALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCA 275 + + ++ G+NC + + + L ++ + +PN+G + + Sbjct: 238 R-HVKPISFGLNCALGPDELREYVSDLSRISECYVSAHPNAGLP-----NAFGEYDLSPE 291 Query: 276 QLADYLPQWQAAG-ARLIGGCCRTTPADIAALK 307 +A+++ +W ++G LIGGCC TTP I + Sbjct: 292 DMAEHVAEWASSGFLNLIGGCCGTTPEHIRQMA 324 >UniRef50_B8FX16 Homocysteine S-methyltransferase n=2 Tax=Desulfitobacterium hafniense RepID=B8FX16_DESHD Length = 285 Score = 253 bits (647), Expect = 6e-66, Method: Composition-based stats. Identities = 76/301 (25%), Positives = 120/301 (39%), Gaps = 26/301 (8%) Query: 10 LLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITA 69 +LDK ++ DGAM T L+ +LA + + PE+I EVH Y +AG+ T Sbjct: 2 ILDKDSYVIFDGAMGTMLQKY--DLAPGQPPEVLNITRPEVIEEVHRKYIKAGSNIITTN 59 Query: 70 SYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYL 129 ++ A G + + A AG LVA VGP G + Sbjct: 60 TFGAIETKLNGTGYSVEEV-------------VQSAIAIARRAAGKNLVALDVGPTGELI 106 Query: 130 ADGSEYRGDYHCSVEAFQAFHRPRVE-ALLDAGADLLACETLPNFSEIEALAELLTAYPR 188 + S E + +++ A L DL+ ET + +E A + Sbjct: 107 EPLGDL------SFEEVYDLYACQIKAAALTGNVDLVLIETFFDLTEAHAAIRAAKDHSS 160 Query: 189 ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTV 247 +FT + G ++ VV L Y V A+G+NC + ++ + T Sbjct: 161 LPVICTFTFQQKGRTLMGKDIKTVVTSLEEY-GVDAVGVNCSLGPGEMLSIVETMVSSTQ 219 Query: 248 LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 LP++V PN+G +T + + A Y+ G + GGCC TTP I+A+K Sbjct: 220 LPILVQPNAGLPKLIGDRTV--YDVEPEEFARYIQVMANLGVKWFGGCCGTTPEFISAIK 277 Query: 308 A 308 Sbjct: 278 E 278 >UniRef50_B8I366 Homocysteine S-methyltransferase n=1 Tax=Clostridium cellulolyticum H10 RepID=B8I366_CLOCE Length = 434 Score = 253 bits (646), Expect = 7e-66, Method: Composition-based stats. Identities = 64/294 (21%), Positives = 115/294 (39%), Gaps = 21/294 (7%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 ++ +L+ DG+M L+++G + + + +PE+++E++ Y AGA + ++Q Sbjct: 8 EKKVLVFDGSMGIMLQSKGLEVGT--CPEEWNITHPEMVKEIYTAYRDAGANVIQSNTFQ 65 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 + + GL + + V LA++ VA S+GP G L Sbjct: 66 SNLMKLSEYGLQDKHY-DINFAGVSLAKEV---------MGDKGYVAASIGPLGKLLEPF 115 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 E E + +V A+ GAD+++ ET + SE+ Sbjct: 116 GELT------FEQAYNTFKEQVVAVTAGGADIISFETFTDVSEMRIALLASKENCNLPVI 169 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVV 252 S + + G+ +L +G NC + +G T L + Sbjct: 170 CSISYEQNGRTLMGSDPAVCACILHSL-GADMIGTNCSFGPEYMIKVAESYGKTGLKFSI 228 Query: 253 YPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 PN+G + E + A+Y ++ GARL+GGCC T P IA + Sbjct: 229 KPNAGIPKTVDGNLV--YDETPEKFAEYAQEFIKYGARLVGGCCGTRPEFIAEI 280 >UniRef50_A9FZY9 Methylenetetrahydrofolate reductase n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9FZY9_SORC5 Length = 624 Score = 252 bits (645), Expect = 9e-66, Method: Composition-based stats. Identities = 88/311 (28%), Positives = 129/311 (41%), Gaps = 24/311 (7%) Query: 1 MSQNNPLRALLD--KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDY 58 MS+ P LD ++ IL+ DGAM + L RG + + ++ V P+L++++H +Y Sbjct: 4 MSRTRPEAPFLDALRRSILVFDGAMGSLLYERGVFVTQNF--EQLNVARPDLVKKIHAEY 61 Query: 59 YRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLV 118 AGA T ++ A GL + + LAR+ G V Sbjct: 62 VAAGANVIETNTFGANRFRLERYGL-VNEVRNFNLAGARLAREIA---------GGDAYV 111 Query: 119 AGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE- 177 AGS+GP G L G R D A A + AL + GADLL ET + EI+ Sbjct: 112 AGSIGPTG--LVPGVATRDDLA----AASATFAEQAGALAEGGADLLILETFRHLDEIKL 165 Query: 178 ALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTA 237 A+ +A P S T S +DG+ V L + V LG+NC + Sbjct: 166 AIDAARSAAPGLPVLASMTFDTSGVAADGSEPERVARTLRDW-GVELLGVNCGDGPQLSL 224 Query: 238 ALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCR 297 A+ LPL V PN+G + + + + AGA +IGGCC Sbjct: 225 AMAERMATAGLPLCVQPNAGLPRTVDGR--QLYMATPEYFDVFARRMIQAGAAMIGGCCG 282 Query: 298 TTPADIAALKA 308 TTP + + Sbjct: 283 TTPEHVRWMAK 293 >UniRef50_Q6AL45 Related to 5-methyltetrahydrofolate--homocysteine methyltransferase n=1 Tax=Desulfotalea psychrophila RepID=Q6AL45_DESPS Length = 316 Score = 252 bits (645), Expect = 1e-65, Method: Composition-based stats. Identities = 77/307 (25%), Positives = 131/307 (42%), Gaps = 29/307 (9%) Query: 14 QDILLLDGAMATELEARGCNLADSLW------SAKVLVENPELIREVHLDYYRAGAQCAI 67 + +L+ DGA T L++ N+A S W + + + PE I E+H + AGA Sbjct: 6 ESLLIFDGACGTTLQS--MNIAPSAWGDLAGCNEFLNISAPEYIIELHKKFLEAGAMVVE 63 Query: 68 TASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGA 127 T ++ A+ GL E + + ++V+ A+KA + +AGS+GP Sbjct: 64 TNTFGASSIVLTEYGL-ENKVDEINREAVKNAKKAI---SQLKDSSQPRYIAGSIGPTTK 119 Query: 128 YLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA----ELL 183 + G H + R +V +LL+AG D L ET + +++ E+L Sbjct: 120 LPSLG-------HIETKVLAQSIREQVISLLEAGVDALIVETCQDLLQLKTALISCFEIL 172 Query: 184 TAYPRA-RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 P+ S T + GT + V A LA +P + +LG+NC + + +Q+ Sbjct: 173 DVAPKKLPVLASVTFEKQGTMLLGTDIAAVCATLAPFP-LFSLGLNCATGPTDMVSQIQY 231 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ-AAGARLIGGCCRTTP 300 L + PN G KT H+ + + ++ ++ G ++GGCC T P Sbjct: 232 LSQTWDKRISCIPNQGMPELKDGKT--HYPLSPEEYSQHMLKFVAEYGVSIVGGCCGTGP 289 Query: 301 ADIAALK 307 I L Sbjct: 290 EHIRQLA 296 >UniRef50_A3TGH3 Homocysteine methyltransferase n=1 Tax=Janibacter sp. HTCC2649 RepID=A3TGH3_9MICO Length = 305 Score = 252 bits (644), Expect = 1e-65, Method: Composition-based stats. Identities = 120/303 (39%), Positives = 165/303 (54%), Gaps = 18/303 (5%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 + ALL + +LDG +T LEARG +L+ LWSA++L + P + H + AGA+ Sbjct: 14 IDALLHTGPV-VLDGGFSTALEARGHDLSGRLWSARLLRQAPSEVVAAHRTFVDAGAEIV 72 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 I+ASYQA+ AG+ A GL E + A + S+ELAR+ + G LVA SVGPYG Sbjct: 73 ISASYQASHAGYVAAGLTEEECDADLDASIELARQGAD---------GRALVAASVGPYG 123 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA- 185 A+LADGSEY G S + FH R+E L+ AG DL+A ET+P +E E + ELLT Sbjct: 124 AHLADGSEYTGYPAVSRATLREFHSRRLERLIAAGPDLVAVETIPEVAEAEVVVELLTEI 183 Query: 186 YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL 245 P W SF+ L+ G P + + ++ G +A+G+NC A + L+ G Sbjct: 184 APDLPYWVSFSATGGGRLTGGAPFAEAIGVVRG--AAIAVGVNCTAPRHIDELLE--AGG 239 Query: 246 TVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLA-DYLPQWQAAGARLIGGCCRTTPADIA 304 +P V+YPN+G YD SKTW G A A + +W GAR IGGCC I Sbjct: 240 PNVPYVIYPNAGATYDPGSKTWTEDG--SAHFAPTTVQRWNDLGARFIGGCCGIGADGIR 297 Query: 305 ALK 307 + Sbjct: 298 EIA 300 >UniRef50_Q146H9 Methionine synthase (B12-dependent) n=21 Tax=cellular organisms RepID=Q146H9_BURXL Length = 359 Score = 252 bits (643), Expect = 1e-65, Method: Composition-based stats. Identities = 86/329 (26%), Positives = 137/329 (41%), Gaps = 32/329 (9%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEA--------RGCNLADSLW-----SAKVLVENP 48 ++ L ALL K IL+LDGAM T ++ RG D + + + P Sbjct: 18 TRGAALPALL-KSRILILDGAMGTMIQRYKLDEARYRGERFKDYGRDIKGNNELLSITQP 76 Query: 49 ELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLA 108 ++I E+H Y AGA T ++ AT A G+ EA + + +S +LAR A + Y Sbjct: 77 QIISEIHEQYLAAGADIVETNTFGATTVAQADYGM-EALAVEMNLESAKLARAACDKYST 135 Query: 109 ENPQAGTLLVAGSVGPYG--AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLA 166 + VAG++GP A ++ G + + + +A + + ALLD G DL Sbjct: 136 PD---KPRFVAGAIGPTPKTASISPDVNDPGARNVTFDELRAAYYEQARALLDGGVDLFL 192 Query: 167 CETLPNFSEIEALAELLTAY-----PRARAWFSFTLRD-SEHLSDGTPLRDVVALLAGYP 220 ET+ + +A L R S T+ D S + G + + + Sbjct: 193 VETIFDTLNAKAALFALDELFEDTGERLPIMISGTVTDASGRILSGQTV-EAFWNSLRHA 251 Query: 221 QVVALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLAD 279 + + G+NC + + L L + YPN+G + E A + Sbjct: 252 KPLTFGLNCALGAALMRPYIAELAKLCDTYVSCYPNAGLPNPMSDTGF---DELPADTSG 308 Query: 280 YLPQWQAAG-ARLIGGCCRTTPADIAALK 307 L ++ AG + GGCC TTP IAA+ Sbjct: 309 LLKEFAQAGLVNIAGGCCGTTPEHIAAIA 337 >UniRef50_C1SMZ8 5-methyltetrahydrofolate--homocysteine methyltransferase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SMZ8_9BACT Length = 1116 Score = 252 bits (643), Expect = 2e-65, Method: Composition-based stats. Identities = 77/310 (24%), Positives = 130/310 (41%), Gaps = 34/310 (10%) Query: 11 LDKQDILLLDGAMATELEARGCNLADSLW------SAKVLVENPELIREVHLDYYRAGAQ 64 K I+L DGAM T ++ + D +W S + V PE+I+++H Y+ AGA Sbjct: 5 FAKNRIILFDGAMGTSIQNY--EITDEIWQGYNGCSEWLNVAAPEIIQQIHEQYFEAGAD 62 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP 124 T ++ T + L + ++ L ++AR+A + Y AGS+GP Sbjct: 63 VVETNTFGGTELVMSEYDLQD-RTYELNLLGAQIARRAADKYGK--------YTAGSIGP 113 Query: 125 YGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 G++ S + + + EALL+ G DL ET + +I++ + Sbjct: 114 -------GTKLPSLGQISYDDLYTMYHSQAEALLEGGVDLFIIETCQDLLQIKSALNAVI 166 Query: 185 AYP-----RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAA 238 A S T+ + + GT + V LL YP V +LG+NC + Sbjct: 167 DVKAEKNSDAPVMVSITVEQNGTMLMGTDISAAVTLLREYP-VFSLGLNCSTGPDLMHNP 225 Query: 239 LQHLHGLTVLPLVVYPNSGEHYDAVSK-TWHHHGEHCAQLADYLPQWQAAGARLIGGCCR 297 + L + PN+G + + + + A++ + + Q G +GGCC Sbjct: 226 INDLAQNFNGRISCIPNAGLPENRGGQMVYDMTPDKMAKIVEGMVQEFPIGV--LGGCCG 283 Query: 298 TTPADIAALK 307 TTP I AL+ Sbjct: 284 TTPEHIKALR 293 >UniRef50_A9A1I5 Homocysteine S-methyltransferase n=2 Tax=Thaumarchaeota RepID=A9A1I5_NITMS Length = 320 Score = 251 bits (642), Expect = 2e-65, Method: Composition-based stats. Identities = 72/321 (22%), Positives = 126/321 (39%), Gaps = 25/321 (7%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLAD-----SLWSAKVLVENPELIREVH 55 M++ P L + +LL DGAM TE++ D ++ ++V P+ I+++H Sbjct: 1 MTEKEPFLDAL-QNRVLLFDGAMGTEIQKFNPKPEDFPNNQDGFNDGLVVTRPDWIKQIH 59 Query: 56 LDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGT 115 Y AGA C T S+ + G + Q+ K +LA + + Y Sbjct: 60 RHYLDAGADCIETNSFGSNKIKLDEYGFGD-QTIEFNKKIAQLASEVCQEY-----SDRP 113 Query: 116 LLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE 175 V GS+GP G + G + + + E L+ G D L ET + E Sbjct: 114 RYVIGSMGPSGFLPSSNDPDLGQKPL--DEIKEAFELQAEGLILGGVDALLIETSQDILE 171 Query: 176 IEALAELL-----TAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC- 229 ++ + E + + TL + GT ++ ++ + G+NC Sbjct: 172 VKLVIEACHQAMEKTGKKIPIIANTTLDQYGKMLLGTNIQAAYTTVSDM-GIDVFGMNCS 230 Query: 230 IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHC--AQLADYLPQWQAA 287 T +++ L ++V PN+G + + + L D+L Q++ Sbjct: 231 TGPIEMTPSVRWLDEQNEHNILVVPNAGMPENEGGQAVYKMTPEKMGDALGDFLNQYKK- 289 Query: 288 GARLIGGCCRTTPADIAALKA 308 R+IGGCC T P I L+ Sbjct: 290 -VRIIGGCCGTNPEHIKVLRK 309 >UniRef50_C3PEG0 Homocysteine S-methyltransferase n=3 Tax=Corynebacterium RepID=C3PEG0_CORA7 Length = 292 Score = 251 bits (642), Expect = 2e-65, Method: Composition-based stats. Identities = 112/293 (38%), Positives = 154/293 (52%), Gaps = 10/293 (3%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 LLLDG + T LEA+G +++ LWSA+VL ENP L+ H D++ AGAQ A TASYQ T Sbjct: 7 PLLLDGGLGTHLEAQGHDISGPLWSARVLRENPTLLESAHADFFAAGAQVATTASYQVTF 66 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 ++AL+ +SV +AR+A + ++ G LLVA S+GPYGA G++Y Sbjct: 67 DVLGE------DAEALLRRSVAVAREAVRVAVDKHTAHGDLLVAASIGPYGAGPGKGTDY 120 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 G Y Q +H R+ L D AD L ET+PN E AL ELL A P+ S Sbjct: 121 DGAYDLRRGELQRWHARRIAVLADTDADFLLAETIPNVDEAAALLELLKAQPK-PFALSI 179 Query: 196 TLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYPN 255 T +D L V+ L ++ ALG+NC++ A + L T PL+ PN Sbjct: 180 T---GAIAADQAKLSQVIELANQSSRLGALGVNCVSPSQARAVVATLRAGTDKPLLACPN 236 Query: 256 SGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 SGE +D + W L + Q +AAG ++GGCCR PA+I L+ Sbjct: 237 SGEVWDCTAHDWQPAPADAMSLPEAALQLRAAGVSVLGGCCRVGPAEIRQLRR 289 >UniRef50_UPI0001C311AB homocysteine S-methyltransferase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C311AB Length = 1189 Score = 251 bits (641), Expect = 3e-65, Method: Composition-based stats. Identities = 82/317 (25%), Positives = 127/317 (40%), Gaps = 29/317 (9%) Query: 7 LRALLD--KQDILLLDGAMATELEARGCNLAD-----SLWSAKVLVENPELIREVHLDYY 59 +R LD + +++ DG M LE D +++ P++I VH Sbjct: 1 MRDYLDAIRSRVVVFDGGMGATLEQFELTEKDYGGLQGKCHEALILHRPDVIEGVHTTML 60 Query: 60 RAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVA 119 AGA T ++QA+ GL E + + E+ARKA + VA Sbjct: 61 DAGADVVETDTFQASRLKLEEWGLGEHTL-EINRRGAEIARKAAGEH---------RYVA 110 Query: 120 GSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA- 178 GS+GP G S+ + S A + + L++ GADLL ET + E++A Sbjct: 111 GSIGPTGFL--PASDDPTLGNISFRALVEVFAEQAQGLIEGGADLLMIETAQDILEVKAS 168 Query: 179 ---LAELLTAYPRA-RAWFSFTL-RDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IAL 232 E R S +L + + GT + V+ L V ALG+NC Sbjct: 169 VFGAREAFKTTGRKIPIQVSVSLLPNGGKMLLGTDISAVLTTLTAL-DVDALGLNCSTGP 227 Query: 233 ENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQA-AGARL 291 E+ A++ L + +P+ PN+G E LA L ++ G + Sbjct: 228 EDMRDAIRFLGEFSPVPVHCIPNAGLPLQG-PDGETIFPEKPEPLAASLTEFVERYGVSI 286 Query: 292 IGGCCRTTPADIAALKA 308 +GGCC TT A I A+ Sbjct: 287 VGGCCGTTAAHIRAIAD 303 >UniRef50_O06745 5,10-methylenetetrahydrofolate reductase n=78 Tax=Bacillus RepID=YITJ_BACSU Length = 612 Score = 250 bits (640), Expect = 3e-65, Method: Composition-based stats. Identities = 75/297 (25%), Positives = 126/297 (42%), Gaps = 27/297 (9%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 ++ +L+ DGAM T L + G + ++ + PE I+ +H Y AGA T +Y Sbjct: 8 QRQVLIGDGAMGTLLYSYGID----RCFEELNISKPEEIQRIHKAYVEAGANIIQTNTYG 63 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A + GL E K + ++V++AR AG V G++G G + Sbjct: 64 ANYIKLSRHGL-EDDIKKMNQEAVKIAR----------ASAGDAYVLGTMG--GIRTFNK 110 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 + Y S++ + R ++ LL D L ET + E + ++ Sbjct: 111 NAY------SLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETDLPIM 164 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLV 251 + ++ + L DGTPL D + +A +GINC + + AL + + L Sbjct: 165 LNVSMHEQGVLQDGTPLSDALRSIADL-GADIVGINCRLGPYHMIEALSEVPIFDDVFLS 223 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 VYPNS + + + + +++ GAR+IGGCC TTP I A+ Sbjct: 224 VYPNSSLPSLEEGRLVYETDDT--YFQNSASEFRKQGARIIGGCCGTTPNHIRAMAE 278 >UniRef50_A6QBA6 5-methyltetrahydrofolate--homocysteine methyltransferase n=6 Tax=Bacteria RepID=A6QBA6_SULNB Length = 1169 Score = 250 bits (640), Expect = 3e-65, Method: Composition-based stats. Identities = 74/326 (22%), Positives = 132/326 (40%), Gaps = 35/326 (10%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLW-----------SAKVLVENPE 49 MS +++LL+K IL++DGAM T+++ ++ W + + + Sbjct: 1 MSITETIKSLLEK-RILVIDGAMGTQIQD--LDVPKEAWIDHSGKEQEGCNELLNDTAAD 57 Query: 50 LIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAE 109 LI+ +H Y AGA T ++ P + E ++ L K EL ++ Y + Sbjct: 58 LIKRIHKRYAMAGADLIKTNTFGTMPWVLDEYQMGE-RAYELSKKGAELVKEICAEYSTK 116 Query: 110 NPQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACET 169 V GS+GP G++ H + ++ L+D G D+ ET Sbjct: 117 IS---PKFVLGSIGP-------GTKLPSLGHIHYDEMYEGYKTVALGLIDGGCDVFLLET 166 Query: 170 LPNFSEIEALAELLTAYPR-----ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVA 224 + +I+A + S T+ S + GT +V ++ + +++ Sbjct: 167 CQDPLQIKAALHACQDANKERGVELPVMVSVTIELSGSMLIGTDATTIVTIMEPF-DILS 225 Query: 225 LGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQ 283 LG NC + L+ L L +P+ V+ N+G + T++ G + + Sbjct: 226 LGFNCGTGPDQVKKHLKTLSELCSIPISVHANAGLPQNRGGYTYYPMG--PDEFTQKQLE 283 Query: 284 WQA-AGARLIGGCCRTTPADIAALKA 308 + G +GGCC TTP I ALK Sbjct: 284 FTEFDGVSFLGGCCGTTPQHIQALKK 309 >UniRef50_B3QGP3 Methionine synthase n=71 Tax=cellular organisms RepID=B3QGP3_RHOPT Length = 1293 Score = 250 bits (639), Expect = 4e-65, Method: Composition-based stats. Identities = 77/321 (23%), Positives = 132/321 (41%), Gaps = 32/321 (9%) Query: 11 LDKQDILLLDGAMATELEA--------RGCNLADSLW-----SAKVLVENPELIREVHLD 57 L Q IL+LDGAM T ++ RG D + +++ P+ I ++H Sbjct: 15 LAAQRILVLDGAMGTMIQQLQLDEAAFRGERFKDFHRDLRGNNDLLILTQPQAIEDIHAQ 74 Query: 58 YYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLL 117 Y RAGA T ++ +T A + E + + LAR A AE Sbjct: 75 YLRAGADIVATNTFSSTSIAQADYDMSEL-AYEMSRDGARLARNAAAKVEAE--DGKPRF 131 Query: 118 VAGSVGPYG--AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE 175 VAG++GP A ++ G + + + + ++ LLD GAD+L ET+ + Sbjct: 132 VAGAIGPTNRTASISPDVANPGYRAVTFDDLRIAYSEQINGLLDGGADILLLETIFDTLN 191 Query: 176 IEALAELLTAYPRA-----RAWFSFTLRD-SEHLSDGTPLRDVVALLAGYPQVVALGINC 229 +A + A S T+ D S L G + + + + + +G NC Sbjct: 192 AKAALYAIAEITEARGIDVPVMISGTITDKSGRLLSG-QMPEAFWNSVRHARPITIGFNC 250 Query: 230 -IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG 288 + ++ A + + + + YPN+G + + E +A + ++ AG Sbjct: 251 ALGAKDLRAHIADISRVADTLVCAYPNAGLP-----NEFGQYDESPEYMASLVGEFAEAG 305 Query: 289 -ARLIGGCCRTTPADIAALKA 308 ++GGCC TTPA I A+ Sbjct: 306 LVNIVGGCCGTTPAHIKAIAE 326 >UniRef50_B5YB64 5-methyltetrahydrofolate-homocysteine methyltransferase n=1 Tax=Dictyoglomus thermophilum H-6-12 RepID=B5YB64_DICT6 Length = 289 Score = 250 bits (638), Expect = 6e-65, Method: Composition-based stats. Identities = 76/298 (25%), Positives = 120/298 (40%), Gaps = 26/298 (8%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 + L DGAM TEL+ RG + +ENP L+ EVH DY +AG+ T ++ Sbjct: 9 EFLFFDGAMGTELQRRGLPPGTP--PEVLNLENPTLVEEVHRDYIKAGSMVIETNTFGGN 66 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 GLD + K + K VE+A+KA E G +L+AGSVGP G + + Sbjct: 67 RIRLKRAGLD-GKIKEINEKGVEIAKKASE---------GKVLIAGSVGPLGELIEPYGD 116 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 S E + ++E L+ +G DL+ ET+ + +E + + + Sbjct: 117 ------ISEEEAEEVFTEQIEILVKSGVDLILIETMISLNEALIALKSAKKF-DIPVGVT 169 Query: 195 FTL---RDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPL 250 + G + + L +G NC E+ + T LP+ Sbjct: 170 MSFEWTERGGRTPFGDEVEYSIKTLEE-NGADFVGANCGRGFEDMIKIAPIIRKATTLPV 228 Query: 251 VVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 ++ PN+G K + E + ++ + IGGCC TTP I K Sbjct: 229 LIQPNAGIPQWENGKL--TYPETPDKFKIFVEEMLKLNINFIGGCCGTTPNHIEVFKE 284 >UniRef50_C4LIL8 5-methyltetrahydrofolate--homocysteinemethyltransferase n=7 Tax=Actinomycetales RepID=C4LIL8_CORK4 Length = 1240 Score = 247 bits (631), Expect = 3e-64, Method: Composition-based stats. Identities = 63/318 (19%), Positives = 127/318 (39%), Gaps = 24/318 (7%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEARGCNLADSL-----WSAKVLVENPELIREVHL 56 ++ L+AL D +L+ DGAM T+L+A +L + + + P+++ ++H Sbjct: 24 KKSEFLQALHD--RVLIGDGAMGTQLQAIDLDLDADFHGLEGCNEILNITRPDILADIHR 81 Query: 57 DYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTL 116 Y+ AGA T ++ FA G+ E + + + ++AR + + + Sbjct: 82 RYFEAGADAVETNTFGCNLPNFADYGI-EDRIEEIAYAGTQIARSVADD-MGPGREGMKR 139 Query: 117 LVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEI 176 V GS+GP G++ + + + L+ GAD + ET + ++ Sbjct: 140 FVLGSLGP-------GTKLPTLGNAPFSDLRDAYTEAAHGLVRGGADAILIETAQDLLQV 192 Query: 177 EALAELLTAYPR-----ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-I 230 +A + T+ + + G+ + + L + +G+NC Sbjct: 193 KAAVHGVQQAFDDYGTTLPIMCHVTVETTGTMLLGSEIGAALTALE-RLGIDVIGMNCAT 251 Query: 231 ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGAR 290 + L++L +P+ V PN+G + + A + + G Sbjct: 252 GPDEMNEHLRYLSAHAPMPVSVMPNAGLPELGANGAVYPLTPDELAAAS-VHFVRDYGLS 310 Query: 291 LIGGCCRTTPADIAALKA 308 ++GGCC TTP I A++ Sbjct: 311 MVGGCCGTTPEHITAVRD 328 >UniRef50_B8DYM9 Homocysteine S-methyltransferase n=1 Tax=Dictyoglomus turgidum DSM 6724 RepID=B8DYM9_DICTD Length = 290 Score = 247 bits (630), Expect = 5e-64, Method: Composition-based stats. Identities = 77/298 (25%), Positives = 123/298 (41%), Gaps = 26/298 (8%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 + L DGAM TEL+ RG + +ENP L+ EVH DY +AG+ T ++ Sbjct: 10 EFLFFDGAMGTELQRRGLPPGTP--PEILNLENPSLVEEVHKDYIKAGSMVIETNTFGGN 67 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 GL+E + K + K VE+A+KA E G +L+AGSVGP G + + Sbjct: 68 RVRLQRAGLEE-KIKEINEKGVEIAQKASE---------GKVLIAGSVGPLGELIEPYGD 117 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 S E + F ++E L+++G DL+ ET+ + +E + + + Sbjct: 118 ------ISEEEAEEFFTEQIEILVNSGVDLILIETMISLNEALIALKSAKKF-DIPVGVT 170 Query: 195 FTL---RDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPL 250 + G + + L +G NC E+ + T LP+ Sbjct: 171 MSFEWTEKGGRTPFGDEVEYSIKKLEE-NGADFVGSNCGKGFEDMLKIAPIIRRSTRLPV 229 Query: 251 VVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 ++ PN+G K + E + ++ + IGGCC TTP I K Sbjct: 230 LIQPNAGIPRWENGKL--LYPESPEKFKTFVDEMIKLKINFIGGCCGTTPKHIEVFKE 285 >UniRef50_C3RK90 Homocysteine S-methyltransferase n=3 Tax=Bacteria RepID=C3RK90_9MOLU Length = 793 Score = 246 bits (629), Expect = 6e-64, Method: Composition-based stats. Identities = 73/297 (24%), Positives = 124/297 (41%), Gaps = 20/297 (6%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K DIL+ DGAM T+L+ G D + + +P+LI+ +HL+Y AGA T ++ Sbjct: 16 KNDILVFDGAMGTQLQDAGLKAGDI--PECLNITDPKLIQTIHLNYLNAGADFITTNTFG 73 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A P A + +I +++ A AR+ +N + +GP G L Sbjct: 74 ANPLKMAEAPYS---YEEIINAAIDNATIARKTADRQNDS----YIVLDIGPIGQLLEPM 126 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 D EA++ + + A D + ET+ + E++A + + Sbjct: 127 GTLTFD-----EAYEIIKKQVIIA--KDKVDAVLLETMTDIYEVKAGILAVKENSDLPVF 179 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLV 251 + T ++ G +V +L G V LG+NC T + + +P++ Sbjct: 180 VTMTYENNLRTLSGCDPLTMVNVLEGL-NVDVLGVNCSLGPIELTPIIDQILAAATIPVL 238 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 + PN+G KT ++ + + G +IGGCC TTP IA+LK Sbjct: 239 LQPNAGLPCLVEGKTCYNMDKET--FVQESLKHVKNGVAIIGGCCGTTPDFIASLKN 293 >UniRef50_A8SP62 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=A8SP62_9FIRM Length = 808 Score = 246 bits (629), Expect = 7e-64, Method: Composition-based stats. Identities = 71/305 (23%), Positives = 123/305 (40%), Gaps = 21/305 (6%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 R L D + IL+LDGA T L G L + + ++E+ +++ ++ Y AG Sbjct: 2 NKTEFRKLFDDK-ILILDGATGTNLMDAGMPLG--VCPEQWILEHKQIMIDLQTAYLNAG 58 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 ++ GL + ++ + V+L++KA E AG LVAG + Sbjct: 59 TDILYAPTFTCNRIKLNEYGLADNLV-SMNSELVKLSQKAVE-------NAGHGLVAGDI 110 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 G L + E ++ +++ L ++G DLL ET+ + +E A Sbjct: 111 TMTGEMLYPMGKL------QFEELVDVYKEQIKVLDESGCDLLVVETMMSLAETRAAVIA 164 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 + S T + GT V +L V A+G+NC + ++ Sbjct: 165 ANEVSKLPIIASLTFNEDGRTLYGTDPVTAVNVLQNL-GVAAIGVNCSTGPDKMVELVKQ 223 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 + + +P+ PN+G K+ + + A + AGA ++GGCC T P Sbjct: 224 MKSIAFIPVFAKPNAGMPELVDDKSVYKM--TPEEFAADMKLIIEAGAGMVGGCCGTRPD 281 Query: 302 DIAAL 306 I AL Sbjct: 282 HIKAL 286 >UniRef50_Q6C0D6 YALI0F25641p n=1 Tax=Yarrowia lipolytica RepID=Q6C0D6_YARLI Length = 348 Score = 246 bits (628), Expect = 8e-64, Method: Composition-based stats. Identities = 115/347 (33%), Positives = 165/347 (47%), Gaps = 58/347 (16%) Query: 16 ILLLDGAMATELEARGCNLADSLW----SAKVLV-------------------------- 45 +L+LDG M TELE RG + +D LW SAK L+ Sbjct: 1 MLILDGGMGTELENRGIDCSDPLWLTLWSAKFLLPINSDFLKCIESADPWTVDQLEKVNR 60 Query: 46 ---ENPE----------LIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALI 92 E+PE L+ +H DY AGA +ASYQA+ G G + +AL Sbjct: 61 ALDEHPEWLESSQDNSNLLYRIHKDYVVAGADIVTSASYQASLEGTIKAGAVQRWPEALW 120 Query: 93 --GKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYRGDY-HCSVEAFQAF 149 KS +L RKA E +L+A SVGP+GA+L G EY GDY + + + Sbjct: 121 MLRKSEQLVRKAV----TEAKVKRKVLLAASVGPFGAWLGGGQEYNGDYTGYTKDDIRRH 176 Query: 150 HRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY---PRARAWFSFTLRDSEH---- 202 H ++ A+L D+L ET+P+ E+E L ++L S +++ +++ Sbjct: 177 HEFKIRAVLGGSPDMLLIETIPSIIEVEVLVDVLNTILPPSPIPVCLSLSVKSADYDRVA 236 Query: 203 LSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYPNSGEHYDA 262 L+DG+ L ++ L A P LG+NC A +L L T L L+VYPNSGE YD Sbjct: 237 LADGSELSNIAELAASCPSFTHLGVNCCAETVAKLSLDILQQHTSLQLIVYPNSGEVYDG 296 Query: 263 VSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKAR 309 +KTW + + A L WQ + ++GGCCRT P IA L+ + Sbjct: 297 ATKTWSGNCDSSFLEAATLSDWQTS-VSILGGCCRTGPPHIAFLRHK 342 >UniRef50_B6GAW1 Putative uncharacterized protein n=1 Tax=Collinsella stercoris DSM 13279 RepID=B6GAW1_9ACTN Length = 848 Score = 245 bits (626), Expect = 1e-63, Method: Composition-based stats. Identities = 78/307 (25%), Positives = 114/307 (37%), Gaps = 27/307 (8%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 + L+ L LL DG M T L+ARG LA + + +PE I +H Y +AG Sbjct: 1 MDTTLQRALAGTGHLLFDGGMGTMLQARG--LAAGELPELLCLTHPEQITAIHQAYVQAG 58 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 + T ++ A A R AQ + + +V AR+ +G LVA + Sbjct: 59 SDVITTNTFGANRLKLAGR----AQVRDVFRAAVACARQ-----------SGARLVAADI 103 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP GA L S + + A DAGADL ET+ + EI+A Sbjct: 104 GPIGALLRPLG------TLSFDEAYDLFAEQAHAAQDAGADLFIIETMTDLLEIKAAVLA 157 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQH 241 + + T GTP L V ALGINC + Sbjct: 158 CREQTDLPIFATMTFEADGRTFLGTPPEVAAVTLDAL-GVDALGINCSQGPAELRPLARR 216 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 + +T P++V N+G + T A + G ++GGCC T P Sbjct: 217 MLAVTEKPVIVQANAGLPHVEDGCTV--FDIEPEAYAQAVAGMVEDGVGILGGCCGTDPR 274 Query: 302 DIAALKA 308 + + Sbjct: 275 HVERMAE 281 >UniRef50_Q5N5P4 5-methyltetrahydrofolate--homocysteine methyltransferase n=16 Tax=Cyanobacteria RepID=Q5N5P4_SYNP6 Length = 1190 Score = 245 bits (625), Expect = 2e-63, Method: Composition-based stats. Identities = 77/315 (24%), Positives = 128/315 (40%), Gaps = 26/315 (8%) Query: 7 LRALLDKQD-ILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREVHLDYY 59 L L + +L+ DG M T L+ + D + ++ PE I VH + Sbjct: 6 LDRLHSPERPVLVFDGGMGTTLQFQNLTAEDFGGPETEGCNEWLIRTKPEAIATVHRQFL 65 Query: 60 RAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVA 119 AGA T ++ AT A GL E + AL VE A+ A+ + VA Sbjct: 66 EAGADVIETDTFGATTIVLAEYGL-EDHAYALN---VEAAKLAKAIAAEFSTPEKPRFVA 121 Query: 120 GSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA- 178 GS+GP G H + +A + L + G DL ET + +I+A Sbjct: 122 GSMGPTTKLPTLG-------HIGYDEMKASFAEQARGLWEGGVDLFIVETCQDVLQIKAA 174 Query: 179 ---LAELLTAYP-RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALE 233 +AE+ + R S T+ + + G+ + ++A+L YP + LG+NC + Sbjct: 175 LNGIAEIFSEKGDRRPLMVSVTMETTGTMLVGSDVAAMLAILEPYP-IDILGLNCATGPD 233 Query: 234 NTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIG 293 +++L + + PN+G + + ++A + + G ++IG Sbjct: 234 RMVEHIKYLSEHSPFVISCIPNAGIPENVGGHAHYRLTPMELRMALH-RFVEDLGVQVIG 292 Query: 294 GCCRTTPADIAALKA 308 GCC T P IA L Sbjct: 293 GCCGTKPEHIAQLAE 307 >UniRef50_A5UPF4 Methionine synthase (B12-dependent) n=5 Tax=Chloroflexaceae RepID=A5UPF4_ROSS1 Length = 1254 Score = 244 bits (623), Expect = 3e-63, Method: Composition-based stats. Identities = 76/309 (24%), Positives = 137/309 (44%), Gaps = 22/309 (7%) Query: 13 KQDILLLDGAMATELEARGCNLAD----SLWSAK--VLVENPELIREVHLDYYRAGAQCA 66 ++ +L+ DGAM T ++ AD + + A+ +++ P++I ++H + AGA Sbjct: 55 RERVLIYDGAMGTSIDTFHLTAADYGGENTFGARDYLVMTRPDVIEQIHTSFLEAGADVL 114 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 T ++Q+T GL + Q+ A+ + LAR+ +A+ E VAGS+GP G Sbjct: 115 ETCTFQSTRIRLEEWGLAD-QTHAINVAAARLARRVADAF--EARDGRPRYVAGSMGPTG 171 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 S+ + + + AL++ G D+L ET + E++A + + Sbjct: 172 KL--PSSDDPSLSDITFDQLSDIFYEQAVALIEGGVDVLLVETSVDILEVKAALDGIRRA 229 Query: 187 ------PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAAL 239 P L S + GT + +VA L P V +G+NC E+ A+ Sbjct: 230 KADLNRPDVAVQAQVFLDLSGKMLLGTEVPALVATLEAMP-VDVIGLNCSTGPEHMREAI 288 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ-AAGARLIGGCCRT 298 +++ + P+ PN+G + +T + A L ++ G ++GGCC T Sbjct: 289 RYMTRHSRKPISCIPNAGLPIEVNGETVYPM--EPEPFARILGEYVHEYGVAVVGGCCGT 346 Query: 299 TPADIAALK 307 PA I L+ Sbjct: 347 RPAHIRRLR 355 >UniRef50_A6LKZ2 Homocysteine S-methyltransferase n=6 Tax=Bacteria RepID=A6LKZ2_THEM4 Length = 781 Score = 243 bits (622), Expect = 4e-63, Method: Composition-based stats. Identities = 68/306 (22%), Positives = 123/306 (40%), Gaps = 24/306 (7%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 + LL+ + I LDGA TE G + V N E++ + Y AG Sbjct: 10 ERKEFLELLN-ERIYFLDGAYGTEFFKLGFKEVI----ETLNVTNSEMVYALQKAYVDAG 64 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 +T ++ A ++ + + K + +V++A+KAR+ + + G + Sbjct: 65 VDFLLTNTFSANRLKLSSLKV-KYNLKDINYNAVKIAKKARK--------DKKVYILGDI 115 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 G ++ E D EA++ F + + E LL++G D ET+ + E++A Sbjct: 116 SSTGYLISPLGELTFD-----EAYEVF-KEQGEILLNSGIDGFILETMSDLKELKAAILA 169 Query: 183 LTAY-PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQ 240 L T + GT + ++ + L V +GINC E + Sbjct: 170 LRDLSKDVPIIVQMTFDEDGVAVTGTSV-EIFSTLMNDLDVDVVGINCTLEPEKLLPVFK 228 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 L + P+ V PN+G+ + + + A Y+ + GA ++GGCC T+P Sbjct: 229 QLSNYSRKPISVEPNAGKPKLLRDGSI-VYNTSPEKFALYMEDFVEFGANIVGGCCGTSP 287 Query: 301 ADIAAL 306 I + Sbjct: 288 EHIRLM 293 >UniRef50_A5TSW8 Methionine synthase n=9 Tax=Fusobacterium RepID=A5TSW8_FUSNP Length = 1082 Score = 243 bits (621), Expect = 5e-63, Method: Composition-based stats. Identities = 71/308 (23%), Positives = 116/308 (37%), Gaps = 25/308 (8%) Query: 13 KQDILLLDGAMATELEARGCNLAD----SLWSAKVLVENPELIREVHLDYYRAGAQCAIT 68 K+ IL+LDGAM T L+ D + P++I EVH Y AGA T Sbjct: 9 KERILVLDGAMGTVLQKYELTPEDFNGAKGCYEILNETRPDIIFEVHKKYIEAGADIIET 68 Query: 69 ASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 S+ L E + L KS E+AR A + + V GS+GP Sbjct: 69 NSFNCNAISLKDYHL-EDKVYDLAKKSAEIARDAVKE------SGKKVYVFGSIGPTNKS 121 Query: 129 LA-DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYP 187 L+ + S + + + +V L+D G D + ET+ + +A Sbjct: 122 LSFPVGDVPYKRAVSFDEMKEVIKVQVAGLIDGGVDGILLETIFDGLTAKAALLATEEVF 181 Query: 188 -----RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQH 241 + S T+ L G + ++A L V + G NC ++ + Sbjct: 182 EEKNVKLPISISATVNRQGKLLTGQSMESLIAAL-DRDSVTSFGFNCSFGAKDLVPLVIK 240 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLA-DYLPQWQAAGARLIGGCCRTTP 300 + LT + ++ N+G + E ++ D LP + ++GGCC T+ Sbjct: 241 IKELTTKFVSLHANAGLPNQNG-----DYVETAQKMRDDLLPLIENQAINILGGCCGTSY 295 Query: 301 ADIAALKA 308 I A+ Sbjct: 296 DHIRAIAE 303 >UniRef50_B0TAJ7 Methionine synthase, putative n=1 Tax=Heliobacterium modesticaldum Ice1 RepID=B0TAJ7_HELMI Length = 807 Score = 243 bits (621), Expect = 5e-63, Method: Composition-based stats. Identities = 73/289 (25%), Positives = 107/289 (37%), Gaps = 22/289 (7%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 I L DGAM T L+A G L + +E+PE + +H Y GA+ T ++ AT Sbjct: 2 IKLFDGAMGTMLQAAG--LLPGACPERFNLEHPERVTAIHRRYVEMGAEIIETNTFGATR 59 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 A + + A A +AGSVGP G +A E Sbjct: 60 LKLAHYRMADQVE----------AVCHAAVRAARAACGPATKIAGSVGPTGKLIAPLGEL 109 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 S E + ++ AL G D + ET+ + E+ A A + Sbjct: 110 ------SFEEAVDVYSEQISALAAVGVDYILIETIIDIQEMRAALLAAKAVAKVPVICQL 163 Query: 196 TLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLVVYP 254 + GT LL +G+NC ++ + G T LP+ P Sbjct: 164 SFGADGRTVTGTDPATAAYLLEAM-GADVIGVNCSLGPAQLLPVIEAIAGATNLPISAQP 222 Query: 255 NSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADI 303 N+G +T + A + P+ AAGA +GGCC TTP I Sbjct: 223 NAGMPELIDGRTVFPM--SPEEFASWAPKLAAAGATYLGGCCGTTPEHI 269 >UniRef50_C7JFY7 Methionine synthase n=8 Tax=Acetobacter pasteurianus RepID=C7JFY7_ACEP3 Length = 1187 Score = 242 bits (619), Expect = 8e-63, Method: Composition-based stats. Identities = 74/320 (23%), Positives = 135/320 (42%), Gaps = 28/320 (8%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLW-----SAKVLVENPELIREVH 55 MS PL L Q +LL DG M + ++ ++ W + + + PELIRE+H Sbjct: 20 MSSRLPLLDALRDQ-VLLCDGGMGSRIQMLDLDVQRDYWGQENCTEILTLSRPELIREIH 78 Query: 56 LDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGT 115 Y+ AGA T ++ +P L + +++ + S LAR+A E++ + T Sbjct: 79 RGYFEAGADMVETNTFGGSPITLGEFSLTD-KAREINKNSAILAREAAESF----ADSRT 133 Query: 116 LLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE 175 V GS+GP G++ + ++ +A + L++ G D + ET + + Sbjct: 134 RYVLGSMGP-------GTKLPSLGNIDYDSLEAALAEQARGLIEGGVDAILIETCQDTLQ 186 Query: 176 IEALAELLTAYPR-----ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC- 229 I+A + + + T+ + L G + ++ V +G+NC Sbjct: 187 IKAAVNGVKIARKELGTTTPIFVQVTVETTGTLLVGPDIAAAATVIHSL-DVDLMGLNCA 245 Query: 230 IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ-AAG 288 + ++ L + V PN+G +T H+ A++A ++ ++ G Sbjct: 246 TGPQEMAEHVKWLSENWPRLISVQPNAGLPELVNGQT--HYPLTPAEMATWVERFITEDG 303 Query: 289 ARLIGGCCRTTPADIAALKA 308 LIGGCC T+ AL A Sbjct: 304 LNLIGGCCGTSTPHTEALDA 323 >UniRef50_C0QY88 5-methyltetrahydrofolate--homocysteine methyltransferase n=2 Tax=Brachyspira RepID=C0QY88_BRAHW Length = 873 Score = 242 bits (619), Expect = 9e-63, Method: Composition-based stats. Identities = 72/325 (22%), Positives = 135/325 (41%), Gaps = 31/325 (9%) Query: 4 NNPLRALLDKQDILLLDGAMATELEARGCNLAD--------SLWSAKVLVENPELIREVH 55 L+ L+ KQ L++DGA TEL+ + + + + P +++E+H Sbjct: 5 KEKLKDLIKKQ-YLIIDGATGTELQKKEIKKESWIINGNNIEGCNEILNITAPNIMKEIH 63 Query: 56 LDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAG- 114 +DY A A T S+ A P + + + ++ L + +A +ARE YL G Sbjct: 64 IDYLNANANITKTNSFGAIPWVLSEYDIAD-KTYELAKSAALIANEAREEYLKNPNSKGD 122 Query: 115 ---TLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLP 171 + +AGS+GP G + S + + V L+D G D++ ET Sbjct: 123 LNRDIFIAGSLGP-------GVKLPSLGQISFDEMYNGYTEAVRGLIDGGVDIILLETAQ 175 Query: 172 NFSEIEALAELLTA-----YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALG 226 + ++++ + S T+ + GT + +L+ + ++G Sbjct: 176 DVLQLKSAILAVNDTAKKLNKEIPIMVSVTIEKEGTMLLGTDIETAYTILSNL-DIFSIG 234 Query: 227 INC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ 285 +NC + ++ L ++ LP+ ++ N+G + K ++ + AD ++ Sbjct: 235 MNCGTGPDMAMRHIKKLSEISYLPISIHSNAGLPENRGGKAYYSM--TPEEFADINSKFF 292 Query: 286 AA-GARLIGGCCRTTPADIAALKAR 309 G IGGCC TTP I AL + Sbjct: 293 ELDGLAFIGGCCGTTPLHINALANK 317 >UniRef50_Q2LQ11 Methylenetetrahydrofolate reductase n=1 Tax=Syntrophus aciditrophicus SB RepID=Q2LQ11_SYNAS Length = 618 Score = 242 bits (617), Expect = 1e-62, Method: Composition-based stats. Identities = 87/303 (28%), Positives = 126/303 (41%), Gaps = 24/303 (7%) Query: 5 NPLRALLDKQD--ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 + L+ +L + L+ DGAM T + +G + ++ + P LI +H Y +AG Sbjct: 2 SALQNVLSRMTGTPLIFDGAMGTMIYEKGVFIQT--CYDELCLTEPGLILGIHEQYAQAG 59 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 AQ T S+ A A GL E + A LA TL VAGSV Sbjct: 60 AQVLETNSFGANRIKLRAYGLAEKVADI----------NRAAARLARQAAGTTLYVAGSV 109 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G G VEA R ++EAL + G DLL ET + E++ A + Sbjct: 110 GP---CTQGGQVITGRDMAEVEA---AFREQMEALTEEGVDLLLLETFSDLKELQLAARV 163 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 SF + D + GTP + A L P V +G+NC AL Sbjct: 164 ARE-RGVPVLASFAVDDDGETAAGTPAEKMAAALEKDPHVDVIGLNCGTGPAGIYEALLK 222 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 + + P++V PN+G + +T + + +Y ++ G R IGGCC PA Sbjct: 223 VLPVAGKPVIVMPNAGMPREIGGRT--LYLANPEYFTEYAKKFIELGVRGIGGCCGVHPA 280 Query: 302 DIA 304 IA Sbjct: 281 HIA 283 >UniRef50_UPI00016C59CA 5-methyltetrahydrofolate--homocysteine S-methyltransferase n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C59CA Length = 1198 Score = 242 bits (617), Expect = 2e-62, Method: Composition-based stats. Identities = 71/328 (21%), Positives = 133/328 (40%), Gaps = 32/328 (9%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLW------------SAKVLVENPE 49 S +P L ++ + +LDG M T L D W S ++ +P+ Sbjct: 4 SFRHPFLDL-ARERVAILDGGMGTSLHKYKPTEKD--WGYSSAGKSLMNLSDALVYTHPD 60 Query: 50 LIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAE 109 IRE+H ++ AG T ++ A G G+ + Q + ++ LA++ + Sbjct: 61 WIREIHRGFFAAGCDGVETNTFNANAIGLGEFGMAD-QLDEINRLNIRLAKEVAAEFA-- 117 Query: 110 NPQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACET 169 V GSVGP G + ++ + ++ +R + +++ D + ET Sbjct: 118 -TADRPRFVIGSVGP-GTKMPSLTDP--AIYIDFDSLADAYRTQFRVMIEERVDAILIET 173 Query: 170 LPNFSEIE-----ALAELLTAYPRARAWFSFT-LRDSEHLSDGTPLRDVVALLAGYPQVV 223 + E + A+ E+ A R T + +++ + GT + + L ++ Sbjct: 174 CFDILEAKCAAVAAIEEMKRAGVRLPLMVQLTIINENKKMLPGTDIATGLVTLDPIDEID 233 Query: 224 ALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLP 282 LG+NC + + ++HL + L V PN+G +T+ A + Sbjct: 234 VLGMNCGVGPDWMDEDVRHLSRHSRKLLSVLPNAGMPETRGDETY--FPLDPEGFAKWQE 291 Query: 283 QWQ-AAGARLIGGCCRTTPADIAALKAR 309 ++ GA +IGGCC TT A + A+ R Sbjct: 292 RFVTEHGANIIGGCCGTTHAHLKAVCDR 319 >UniRef50_D1Y627 Homocysteine S-methyltransferase n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y627_9BACT Length = 798 Score = 242 bits (617), Expect = 2e-62, Method: Composition-based stats. Identities = 66/292 (22%), Positives = 123/292 (42%), Gaps = 23/292 (7%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 +++ DGAM T L+ +G L + + V P+LI +H +Y+ AG T ++ A Sbjct: 7 RVVMFDGAMGTMLQKKGLKLREI--PESLNVSRPDLIESIHREYFAAGCDFVQTNTFGAN 64 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 P +++ +IG +V++AR+A +A+ + + VGP G +A + Sbjct: 65 PYKLEGTAY---ETEQVIGAAVKIARRAADAFSGKG-------ILLDVGPSGRAMAPVGD 114 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 + +V A + D + ET + E +A A + + Sbjct: 115 ------ADFDEIYGSVARQVRAGAEL-CDGILLETFTDLLEAKASALAALENSDKPVFLT 167 Query: 195 FTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLVVY 253 + ++ GTP+ ++ G + LG+NC ++ L + +P++V Sbjct: 168 MSFQEDGRTFFGTPVEAMIMTFEGL-GLSGLGVNCSLGPAQLAPIVKKLTAHSRVPVIVQ 226 Query: 254 PNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAA 305 PN+G V + A++L Q+ G +GGCC TTP ++A Sbjct: 227 PNAGLP--VVRDGVSGWDVSPGEFANWLGQFVDWGTAFVGGCCGTTPEFLSA 276 >UniRef50_Q55786 Methionine synthase n=14 Tax=Cyanobacteria RepID=METH_SYNY3 Length = 1195 Score = 241 bits (616), Expect = 2e-62, Method: Composition-based stats. Identities = 75/307 (24%), Positives = 126/307 (41%), Gaps = 25/307 (8%) Query: 14 QDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREVHLDYYRAGAQCAI 67 + +L+ DGAM T L+ + AD + ++ PE + VH +Y AGA Sbjct: 14 RPVLVFDGAMGTNLQVQNLTAADFGGAEYEGCNEYLVHTKPEAVATVHRAFYEAGADVVE 73 Query: 68 TASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGA 127 T ++ TP A L + QS L + E A+ + VAGS+GP Sbjct: 74 TDTFGGTPLVLAEYDLAD-QSYYLNKAAAE---LAKAVAAEFSTPEKPRFVAGSMGP--- 126 Query: 128 YLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY- 186 G++ H ++ + + +V L D G DLL ET + +I+A + Sbjct: 127 ----GTKLPTLGHVDYDSLKDAYVVQVRGLYDGGVDLLLVETCQDVLQIKAALNAIEQVF 182 Query: 187 ----PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 R S T+ + GT + +A+L YP + LG+NC + +++ Sbjct: 183 AEKGDRLPLMVSVTMETMGTMLVGTEMAAALAILEPYP-IDILGLNCATGPDLMKEHVKY 241 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 L + + PN+G + + ++ Q+ + + G ++IGGCC T P Sbjct: 242 LSEHSPFVVSCIPNAGLPENVGGQAFYRLTPMELQM-SLMHFIEDLGVQVIGGCCGTRPD 300 Query: 302 DIAALKA 308 I AL Sbjct: 301 HIKALAD 307 >UniRef50_A1AKP7 Methylenetetrahydrofolate reductase n=10 Tax=Desulfuromonadales RepID=A1AKP7_PELPD Length = 615 Score = 241 bits (616), Expect = 2e-62, Method: Composition-based stats. Identities = 85/295 (28%), Positives = 124/295 (42%), Gaps = 21/295 (7%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K ++L DGA+ T L ARG L S ++ + P L+RE+ DY AGAQ T ++ Sbjct: 8 KGEVLTGDGALGTMLYARGVGLDSSF--EQLNLTRPALVRELADDYVAAGAQVIETNTFG 65 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A AA GL E + + +AR+A + Q +LVAGSVGP D Sbjct: 66 ANYTRLAALGL-EQRVWEINLAGARIARQAAD-------QGRDVLVAGSVGPLPRIRGDE 117 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 +E E R + +AL + G DLL ET + +++ A + Sbjct: 118 AE------SDQERMAELFRVQCQALAEGGVDLLLLETFSSLTQLAAAVQAARC-TGLTVA 170 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLV 251 S + +DG + + A + +G NC ++ L +T P+ Sbjct: 171 ASMAFLEGGRSADGATVEEFCAAME-RAGADLVGANCGAGPLELVKVVRRLAAVTHKPIT 229 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 Y NSG + LA + AAGA L+GGCC TTP IAA+ Sbjct: 230 AYANSGFP--EYHDGRFIYRATPEYLATMAGELVAAGASLVGGCCGTTPEHIAAI 282 >UniRef50_D0MU48 Methionine synthase n=1 Tax=Phytophthora infestans T30-4 RepID=D0MU48_PHYIN Length = 1203 Score = 240 bits (614), Expect = 3e-62, Method: Composition-based stats. Identities = 82/325 (25%), Positives = 133/325 (40%), Gaps = 34/325 (10%) Query: 11 LDKQDILLLDGAMATELEA--------RGCNLADSLW-----SAKVLVENPELIREVHLD 57 L KQ L+ DG M T ++ R DS + + + P +I+E+H Sbjct: 31 LMKQRTLIFDGGMGTMIQVHKFTEEDFRSERFKDSPCLVKGNNDLLSITQPHIIKEIHKQ 90 Query: 58 YYRAG-AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTL 116 Y + G AQ T ++ T A + E L +S +LAR+A + +P Sbjct: 91 YMQIGRAQLIGTNTFSGTTIAQADYQM-EHLVYELNYESAKLAREAADEVTQLDP-LLPR 148 Query: 117 LVAGSVGPYGAYLA--DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFS 174 VAGS+GP L+ E G + + + + +VE L+D G+D+L ET+ + Sbjct: 149 FVAGSIGPTNRTLSISPNVEDPGFRNVTFDELVDAYYTQVEGLVDGGSDVLLVETIFDTL 208 Query: 175 EIEALAELLTAYPRA-----RAWFSFTLRD--SEHLSDGTPLRDVVALLAGYPQVVALGI 227 +A + Y A + S T+ D LS T V+L P +G+ Sbjct: 209 NAKAAVFAINKYQEATGRKLPLFISGTIVDMSGRTLSGQTTEAFYVSLRHSKP--FCIGL 266 Query: 228 NC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQA 286 NC + LQ L + + VY N+G + + A +A+Y ++ Sbjct: 267 NCALGANQMKPFLQRLANVAECFVSVYANAGLP-----NAMGGYDDTPAMMAEYCEEFSK 321 Query: 287 A-GARLIGGCCRTTPADIAALKARS 310 ++GGCC TTP I A+ + Sbjct: 322 DRLVNMMGGCCGTTPQHIQAIAKMT 346 >UniRef50_Q08985 Homocysteine S-methyltransferase 2 n=17 Tax=Saccharomycetaceae RepID=SAM4_YEAST Length = 325 Score = 240 bits (613), Expect = 5e-62, Method: Composition-based stats. Identities = 89/326 (27%), Positives = 155/326 (47%), Gaps = 34/326 (10%) Query: 6 PLRALL--DKQDILLLDGAMATELEARGCNLADSLWSAKVLVE----------NPELIRE 53 PL+ L + + +L+LDG TELE RG +A+ +WS + N ++++E Sbjct: 5 PLKQFLADNPKKVLVLDGGQGTELENRGIKVANPVWSTIPFISESFWSDESSANRKIVKE 64 Query: 54 VHLDYYRAGAQCAITASYQATPAGFAARG--LDEAQSKALIGKSVELARKAREAYLAENP 111 + D+ AGA+ +T +YQ + + ++ L+ + V+ +R Sbjct: 65 MFNDFLNAGAEILMTTTYQTSYKSVSENTPIRTLSEYNNLLNRIVDFSRNCI-------- 116 Query: 112 QAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVE--AFQAFHRPRVEALLDAG-ADLLACE 168 + G +GP+GA++ E+ GDY E F + +P++E DL+ E Sbjct: 117 -GEDKYLIGCIGPWGAHIC--REFTGDYGAEPENIDFYQYFKPQLENFNKNDKLDLIGFE 173 Query: 169 TLPNFSEIEALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGY-----PQVV 223 T+PN E++A+ + + ++ + L DGT + ++ ++ P Sbjct: 174 TIPNIHELKAILSWDESILSRPFYIGLSVHEHGVLRDGTTMEEIAQVIKDLGDKINPNFS 233 Query: 224 ALGINCIALENTTAALQHLH-GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLP 282 LGINC++ + L+ LH L + L+ YPNSGE YD K W + + + Sbjct: 234 FLGINCVSFNQSPDILESLHQALPNMALLAYPNSGEVYDTEKKIWLPNSDKLNSWDTVVK 293 Query: 283 QWQAAGARLIGGCCRTTPADIAALKA 308 Q+ ++GAR+IGGCCRT+P DI + A Sbjct: 294 QYISSGARIIGGCCRTSPKDIQEISA 319 >UniRef50_Q49775 Methionine synthase n=41 Tax=Bacteria RepID=METH_MYCLE Length = 1206 Score = 240 bits (612), Expect = 7e-62, Method: Composition-based stats. Identities = 65/306 (21%), Positives = 123/306 (40%), Gaps = 25/306 (8%) Query: 14 QDILLLDGAMATELEARGCNLAD----SLWSAKVLVENPELIREVHLDYYRAGAQCAITA 69 Q +++ DGAM T+L+ L D + + P+++ +H Y+ AGA T Sbjct: 21 QRVMVGDGAMGTQLQDAELTLDDFRGLEGCNEILNETRPDVLETIHRRYFEAGADLVETN 80 Query: 70 SYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYL 129 ++ + + + + + L + +AR+ + + V GS+GP Sbjct: 81 TFGCNLSNLGDYDIAD-KIRDLSQRGTVIARRVADELTTPD---HKRYVLGSMGP----- 131 Query: 130 ADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA-----ELLT 184 G++ H + + +LD GAD + ET + +++A + Sbjct: 132 --GTKLPTLGHTEYRVVRDAYTESALGMLDGGADAVLVETCQDLLQLKAAVLGSRRAMTQ 189 Query: 185 AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLH 243 A + T+ + + G+ + +A + V +G+NC + L+HL Sbjct: 190 AGRHIPVFVHVTVETTGTMLLGSEIGAALAAVEPL-GVDMIGLNCATGPAEMSEHLRHLS 248 Query: 244 GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAA-GARLIGGCCRTTPAD 302 +P+ V PN+G + + +LA+ L + A G L+GGCC TTP Sbjct: 249 KHARIPVSVMPNAGLP--VLGAKGAEYPLQPDELAEALAGFIAEFGLSLVGGCCGTTPDH 306 Query: 303 IAALKA 308 I + A Sbjct: 307 IREVAA 312 >UniRef50_C1EAX2 Predicted protein n=36 Tax=cellular organisms RepID=C1EAX2_9CHLO Length = 1378 Score = 240 bits (612), Expect = 7e-62, Method: Composition-based stats. Identities = 73/322 (22%), Positives = 135/322 (41%), Gaps = 31/322 (9%) Query: 11 LDKQDILLLDGAMATELEARGCNLADSLW-------------SAKVLVENPELIREVHLD 57 + K+ I+++DGAM T ++ + D + +++ P++I E+H Sbjct: 122 IMKERIMVIDGAMGTAVQKYKLSEDDFRGERYKNHTHDLKGNNDVLVITRPDVIEEIHTA 181 Query: 58 YYRAGAQCAITASYQATPAGFAARGLD-EAQSKALIGKSVELARKAREAYLAENPQAGTL 116 Y AGA T ++ +T A LD + + L + +LA+K + +NP A Sbjct: 182 YLAAGADIIETNTFNSTMISQADYELDKKEEVYLLNKTAAQLAKKCCVEFTKKNP-AKPR 240 Query: 117 LVAGSVGPYGAYL--ADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFS 174 AG+VGP L + E C+ + + +VEAL+D G D+L ET+ + Sbjct: 241 FAAGAVGPTNKTLSVSPSVENPAFRGCTYDEIVEAYYEQVEALIDGGVDVLLVETIFDTL 300 Query: 175 EIEALAELLTAY-----PRARAWFSFTLRDS-EHLSDGTPLRDVVALLAGYPQVVALGIN 228 +A + Y + + S T+ D+ G + + + +A+G+N Sbjct: 301 NAKAAMFAIDMYFEKWGQKIPVFVSGTIVDNSGRTLSGQT-NEAFWNSMSHSKPIAIGLN 359 Query: 229 C-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAA 287 C + ++ +++L + + YPN+G + + A++A+ + Sbjct: 360 CALGAKDMVPYIENLSRVADCWVFCYPNAGLP-----NAMGGYDQKGAEMAEDCRVFPEK 414 Query: 288 G-ARLIGGCCRTTPADIAALKA 308 G IGGCC TT I L Sbjct: 415 GLINAIGGCCGTTDEHIKCLAD 436 >UniRef50_A8SPV0 Methylenetetrahydrofolate reductase n=2 Tax=Clostridiales RepID=A8SPV0_9FIRM Length = 606 Score = 239 bits (611), Expect = 9e-62, Method: Composition-based stats. Identities = 78/309 (25%), Positives = 132/309 (42%), Gaps = 27/309 (8%) Query: 5 NPLRALLDKQDILLLDGAMAT----ELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 N L +L DK +L+ DGA T RG ++ + +PE + E+H +Y + Sbjct: 2 NILESLRDK--LLVADGAFGTCYAGMYGERG-----TVAPELANMRHPERVLEIHKEYVK 54 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGA T ++ A A A D + + +V+LA++A A VAG Sbjct: 55 AGAGIIRTNTFAANTASLDA---DMDYVISNVRAAVKLAKQAVAETGAPGIDRKKAYVAG 111 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 +GP A D ++ + ++ EA+ D G D++ ET P F+ +E + Sbjct: 112 DIGPIPA----------DAGLTLNERVSQYKLLGEAMQDMGVDIIWFETFPEFNVLEPVV 161 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAAL 239 + L A SF + + + G R +++ A V +G+NC + + L Sbjct: 162 KQLKARKDTPVMVSFCVNQFGYSNCGFSARALLSQAAANSDVDCVGLNCGVGPYHMLQLL 221 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 + L P+ + PN+G Y +++ ++ D + A GA +IGGCC T Sbjct: 222 KKLDIDCGKPVSIMPNAG--YPKFTQSRLVFNDNKEGFIDKIQDIAALGADIIGGCCGTN 279 Query: 300 PADIAALKA 308 P I +K Sbjct: 280 PEYIRQIKE 288 >UniRef50_A5DTG6 Putative uncharacterized protein n=1 Tax=Lodderomyces elongisporus RepID=A5DTG6_LODEL Length = 326 Score = 238 bits (609), Expect = 1e-61, Method: Composition-based stats. Identities = 106/329 (32%), Positives = 161/329 (48%), Gaps = 33/329 (10%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEAR------GCNLADSLWSAKVLVENPELIREV 54 MSQN + +K+ ++LDGA+ T LE LWS +VL++ PELI++V Sbjct: 1 MSQN-----IFNKK--VVLDGALGTALEDLIDPSAPYLPSKSPLWSGQVLLDAPELIQKV 53 Query: 55 HLDYYRAGAQCAITASYQATPAGFAAR-GLDEAQSKALIGKSVELARKAR------EAYL 107 H Y AG++ T++YQ + L + Q + +S++L R A Y Sbjct: 54 HEMYIGAGSEVIFTSTYQLSYDSLRKHTTLSDEQILEVWQRSIDLVRAAALSIDETARYT 113 Query: 108 AEN---PQAGTLLVAGSVGPYGAYLADGSEYRGDY-HCSVEAFQAFHRPRVEALLD-AGA 162 E + G + +AGS+GPY AYLA+GSEY GDY + + E +AFH P +E + Sbjct: 114 KEKESRGEPGKVHIAGSIGPYAAYLANGSEYTGDYGNVTDEQLEAFHTPMLEFFTENEAV 173 Query: 163 DLLACETLPNFSEIEALAELLTAY-PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGY-- 219 DL+A ET+PNF E++A+ +L+ + FS T ++ ++L+DGTPL +V L Sbjct: 174 DLIAFETIPNFQELKAVTKLVKRLNCKKPVLFSITCQNLDNLTDGTPLLEVKKYLDFCLP 233 Query: 220 PQVVALGINCIALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWH-HHGEHCAQLA 278 + LGINC+ + H G VYPN G YD + G Sbjct: 234 KEQKILGINCVEYTLVQGIMSHFAGFK---FYVYPNLGFEYDLEKHQFVIKEGRSEDDWR 290 Query: 279 DYLPQWQAAGARL-IGGCCRTTPADIAAL 306 ++ + A + IGGCC T +I + Sbjct: 291 LFVENLASKEAVIGIGGCCNTGVKEIEQI 319 >UniRef50_A7TSR2 Putative uncharacterized protein n=1 Tax=Vanderwaltozyma polyspora DSM 70294 RepID=A7TSR2_VANPO Length = 323 Score = 238 bits (608), Expect = 2e-61, Method: Composition-based stats. Identities = 92/325 (28%), Positives = 152/325 (46%), Gaps = 33/325 (10%) Query: 6 PLRALLDKQ--DILLLDGAMATELEARGCNLADSLWSAKVLV-----------ENPELIR 52 P+ L+ Q ++L+ DG + T LE+RG N++ LWS + + +I Sbjct: 4 PIEELIRNQPDEVLVSDGGLGTLLESRGINVSSPLWSTVPFLKDDFWDSETKTSDRNIIE 63 Query: 53 EVHLDYYRAGAQCAITASYQATPAGFAARGL--DEAQSKALIGKSVELARKAREAYLAEN 110 ++ DY +G++ T +YQ + A + K LI R A Sbjct: 64 GIYRDYITSGSRILSTITYQTSFALISTHTEVKTIEGYKQLIRNITSFCRSAI------- 116 Query: 111 PQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEA--FQAFHRPRVEALLD-AGADLLAC 167 + GS+GP+GA L G+EY G+Y S + + +P++E + D++ Sbjct: 117 --GEDNYLIGSIGPFGARL--GAEYTGNYGDSPSNINYLEYFKPQLEEFNNNDDIDIIGF 172 Query: 168 ETLPNFSEIEALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQ---VVA 224 ET+PN E+EA+ + + S +L D+ L DGT ++ + Y ++ Sbjct: 173 ETVPNKYELEAILSWDKSVISKPYYVSLSLLDNGGLRDGTSFEEIATIFKKYSNNDNLIL 232 Query: 225 LGINCIALENTTAALQHLH-GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQ 283 G NCI+ + + + LH + LPL+VYPNSGE YD ++K W D + + Sbjct: 233 TGANCISFKYASENISKLHQAIPTLPLIVYPNSGEIYDPLTKKWTIDQTFGLTWEDLIKE 292 Query: 284 WQAAGARLIGGCCRTTPADIAALKA 308 + + R++GGCCRTTP DI +K Sbjct: 293 LRTSNVRIVGGCCRTTPDDINKIKD 317 >UniRef50_C4GEB2 Putative uncharacterized protein n=1 Tax=Shuttleworthia satelles DSM 14600 RepID=C4GEB2_9FIRM Length = 841 Score = 238 bits (607), Expect = 2e-61, Method: Composition-based stats. Identities = 73/297 (24%), Positives = 114/297 (38%), Gaps = 22/297 (7%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 I++LDG M T L+A G ++PE++ ++H Y AG+ ++ A Sbjct: 3 NKIIVLDGGMGTMLQAAGMPAGQH--PEVFGHQHPEIVEQIHRQYIEAGSNVIYANTFGA 60 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 +D GK+V A + + + + T+ VA +GP G L Sbjct: 61 NARKLQGCSID-------TGKAVFSAIRTAKRAAQKAAKE-TVRVALDLGPVGELLEPLG 112 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWF 193 S E +R V A +AGADL+ ET + +I+AL W Sbjct: 113 ------TLSFEEAYEIYREAVVAGYEAGADLIVAETFTDLLDIKALVLAAKENTPLPVWT 166 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLVV 252 + T S GT + + L G V A+GINC ++ L T LP++ Sbjct: 167 TMTFERSGRTFTGTTIASMALTLTGL-GVDAIGINCSLGPTEILPLIEELREWTHLPVIA 225 Query: 253 YPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKAR 309 PN+G + + + G ++GGCC T P I L +R Sbjct: 226 KPNAGLPDPRTG----VYDLTAEDFGKQMQAYAELGVSVLGGCCGTDPDYIRCLVSR 278 >UniRef50_A7SKT1 Predicted protein n=4 Tax=Eumetazoa RepID=A7SKT1_NEMVE Length = 1178 Score = 237 bits (604), Expect = 5e-61, Method: Composition-based stats. Identities = 75/315 (23%), Positives = 126/315 (40%), Gaps = 43/315 (13%) Query: 17 LLLDGAMATELEA--------RGCNLADSLWSAK-----VLVENPELIREVHLDYYRAGA 63 ++ DG M T ++ RG + S K + + P+ I ++H Y AGA Sbjct: 1 MIFDGGMGTMIQKLHLEEADFRGEEFKNHPKSLKGNNDLLSITKPDAILDIHKGYLEAGA 60 Query: 64 QCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVG 123 T ++ T A GL++A + L S E+A++A AY VAG++G Sbjct: 61 DFVETNTFSGTKIAQADYGLEDA-AYRLNRASAEVAKRA--AYEVTASTGVEKFVAGAMG 117 Query: 124 PYGAYL--ADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 P L + E G + + + + + LLD G D+L ET+ + + +A Sbjct: 118 PTNRTLSISPTVECPGFRNVTFDELVDAYTEQARGLLDGGVDVLLVETIFDTANAKAALF 177 Query: 182 LL-----TAYPRARAWFSFTLRD--SEHLSDGTPLRDVVALLAGYPQVVALGINC-IALE 233 + Y + S T+ D LS T V+++ P + +G+NC + Sbjct: 178 AIDQLFEKEYSPVPVFVSGTIVDKSGRTLSGQTTESFVISVSHSSP--MCIGLNCALGAV 235 Query: 234 NTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIG 293 ++ + T + YPN+G T+ + E +A +L AR Sbjct: 236 EMRPFIEAVGMNTEAYTICYPNAGLP-----NTFGDYDETPETMAKHLK------AR--- 281 Query: 294 GCCRTTPADIAALKA 308 CC TTP I A+ Sbjct: 282 -CCGTTPEHIRAIAE 295 >UniRef50_UPI0001AEC485 homocysteine S-methyltransferase family protein n=1 Tax=Alteromonas macleodii ATCC 27126 RepID=UPI0001AEC485 Length = 308 Score = 237 bits (604), Expect = 5e-61, Method: Composition-based stats. Identities = 88/305 (28%), Positives = 127/305 (41%), Gaps = 28/305 (9%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 DIL+LDG M EL+ G WSA L++ PEL+ +VH + AGA T +Y Sbjct: 10 DILILDGGMGRELKKTGAPFKQPEWSALALMQTPELVSDVHKRFLEAGACVITTNAYALV 69 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP-YGAYLADGS 133 P E Q+ L + ELAR A A ++ VAGSV P +G+Y D Sbjct: 70 PFHIGENTFRE-QAFTLAQNAAELARGAVNALKSDG--DNKRFVAGSVPPAFGSYRPDLF 126 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWF 193 + P ++A + D+ ET + E EA+ L+ Y W Sbjct: 127 DAT--------RVADILTPLIKA-QEPYVDVWLIETASSVEEAEAVVSLIKQYSSLPLWL 177 Query: 194 SFTLRDSE------HLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL-T 246 SF++ + E L G PL ++ +L +V ++ NC E A+ L T Sbjct: 178 SFSVSNRETSNEPVTLRSGEPLSEIAPIL---SEVQSVLFNCSQPEEMEDAISITRSLDT 234 Query: 247 VLPLVVYPNSGEHYDAVSKTWHHHGE-----HCAQLADYLPQWQAAGARLIGGCCRTTPA 301 + + Y NS E A+ +Y+ W AAGA +IGGCC P Sbjct: 235 SINIGAYANSFSERKRTHAANALLSEIRDDITPARYVEYVKTWVAAGATIIGGCCGIGPE 294 Query: 302 DIAAL 306 I A+ Sbjct: 295 HIKAI 299 >UniRef50_D2UDY2 Probable 5-methyltetrahydrofolate-homocysteine methyltransferase protein n=1 Tax=Xanthomonas albilineans RepID=D2UDY2_XANAL Length = 380 Score = 237 bits (604), Expect = 6e-61, Method: Composition-based stats. Identities = 82/341 (24%), Positives = 137/341 (40%), Gaps = 53/341 (15%) Query: 14 QDILLLDGAMATELEARGCNLAD--------SLWSAK----------------------- 42 + IL++DGAM T ++ G AD SA+ Sbjct: 29 ERILIIDGAMGTMIQRHGLQEADYRGDRFAAGYDSAQPPHVHGPGCDHAMHGHDLKGNND 88 Query: 43 -VLVENPELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARK 101 +L+ PE+I E+H Y AGA T ++ AT A L E L +AR Sbjct: 89 LLLLTRPEVIAEIHSAYLEAGADLLETNTFNATAISQADYHL-EHLVYELNKAGARVARD 147 Query: 102 AREAYLAENPQAG----TLLVAGSVGPY--GAYLADGSEYRGDYHCSVEAFQAFHRPRVE 155 +A A+ +AG V G +GP A ++ G + S + +A +R ++ Sbjct: 148 CCDAVEAQQARAGGPDKPRFVIGVLGPTSRTASISPDVNDPGYRNTSFDELRATYREAID 207 Query: 156 ALLDAGADLLACETLPNFSEIEALAELLTAYPRA-----RAWFSFTLRD-SEHLSDGTPL 209 L+D GAD L ET+ + +A + A S T+ D S G Sbjct: 208 GLIDGGADTLMVETIFDTLNAKAALYAIEEVFDARGGRLPVMISGTITDASGRTLSGQT- 266 Query: 210 RDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWH 268 + + + +++G+NC + ++ ++ L + + +PN+G + Sbjct: 267 AEAFYASVAHGRPLSVGLNCALGAKDLRPHVETLARIADGYVSTHPNAGLP-----NAFG 321 Query: 269 HHGEHCAQLADYLPQWQAAG-ARLIGGCCRTTPADIAALKA 308 + E ++A L ++ AG L+GGCC TTPA I A+ Sbjct: 322 EYDETPEEMAATLKEFAEAGLLNLVGGCCGTTPAHIRAIAE 362 >UniRef50_C4QA25 Putative uncharacterized protein n=1 Tax=Schistosoma mansoni RepID=C4QA25_SCHMA Length = 741 Score = 237 bits (604), Expect = 6e-61, Method: Composition-based stats. Identities = 95/337 (28%), Positives = 148/337 (43%), Gaps = 43/337 (12%) Query: 15 DILLLDGAMATELEARGCNLADS--LWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 +I +LDG TE + D WS+++L+++PEL+ ++H + RAG T +YQ Sbjct: 396 EIRVLDGGFGTESQKLSNLQIDGHLAWSSRLLMDDPELVVKIHKSFLRAGCDVISTNTYQ 455 Query: 73 ATPAGFAAR-GLDEAQSKALIGKSVELARKAREA-----YLAENPQAGTLLVAGSVGPYG 126 A P+ G+ ++K L+ +V LA++ARE +E + +L+AGS+GPYG Sbjct: 456 AAPSTLGKALGISIGEAKNLMHTAVHLAQRAREEENNSVTASEFQRKLPVLIAGSLGPYG 515 Query: 127 AYLADGSEYRGDY--HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 A ADGSEY G Y S FH R + LL++G D +A ET+P E+ ++ E++ Sbjct: 516 ACAADGSEYTGSYANEVSFNELVEFHLSRAKILLESGVDFIAWETVPLLKEVSSICEVMR 575 Query: 185 AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIAL-ENTTAALQHLH 243 P A W S + D E S G L V +A QV +G+NC + L +L+ Sbjct: 576 RLPSAYCWISVSSPDGEKTSGGDLLASVACEVAKCEQVFGVGVNCNIPHDCIGKGLANLN 635 Query: 244 GLTVLP--------LVVYPNSGEHYDAV------SKTWHHHGEHCAQLADYLPQWQA--- 286 T ++ Y N G+ + ++ + QW Sbjct: 636 SQTCKESENTSSKLILFYANDGQLWIPNDGDKKRGHFVNYSQYNHDSWFQNTIQWAKRRE 695 Query: 287 ---------------AGARLIGGCCRTTPADIAALKA 308 A+ +GGCC P I L Sbjct: 696 TSDDEHLHYSVNDKPPLAQWVGGCCNVRPECIRRLAK 732 >UniRef50_C9RQ92 Methionine synthase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RQ92_FIBSS Length = 1217 Score = 236 bits (603), Expect = 7e-61, Method: Composition-based stats. Identities = 63/331 (19%), Positives = 129/331 (38%), Gaps = 42/331 (12%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M+ + ++LLDG M + ++ G A+ + + +E PE+I ++ Y Sbjct: 1 MTLREAFES-----KMMLLDGGMGSVIQTYGIKGAN---NDMLSIEKPEIILDIQRRYVD 52 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AG C T ++ + E + + SV++A++A E + + + G Sbjct: 53 AGVDCLTTNTFSSQRVSQHEYH-QEHRIAEMNRASVKIAKQAAEEGFKKY--GRKVYILG 109 Query: 121 SVGPYGAYL--ADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 VGP L ++ + + + + ++ L++ G D + ET+ + +A Sbjct: 110 DVGPTSKMLSMSEDVNDPASRAITFDELEDAYLEQISVLMEEGVDAILIETIFDTLNAKA 169 Query: 179 LAELLTAYPRAR------------------AWFSFTLRD--SEHLSDGTPLRDVVALLAG 218 + AR S T+ D LS T V+++ Sbjct: 170 ALSAYSKANDARIEAAKAAGTPEAEIKPIEVMLSMTVSDASGRTLSGQTVEAFAVSVMHM 229 Query: 219 YPQVVALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQL 277 +P +++G+NC + + L+ + + L +PN+G + + + + Sbjct: 230 HP--LSIGLNCGLGADGMVPYLRRMGAIAPCYLSCHPNAGLP-----NQFGGYDDTPEDM 282 Query: 278 ADYLPQWQAA-GARLIGGCCRTTPADIAALK 307 + + +IGGCC TTP IAA++ Sbjct: 283 VRLMRVYLDDKLVNMIGGCCGTTPEHIAAMR 313 >UniRef50_C5D740 Methionine synthase n=8 Tax=Bacteria RepID=C5D740_GEOSW Length = 1136 Score = 235 bits (601), Expect = 1e-60, Method: Composition-based stats. Identities = 79/318 (24%), Positives = 129/318 (40%), Gaps = 30/318 (9%) Query: 4 NNPLRALLDKQDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREVHLD 57 N L L+K+ IL++DGAM T +++ + D + + + P +I +H Sbjct: 3 NITLEQQLEKK-ILIIDGAMGTMIQSAKLSADDFGGEAYEGCNEYLTLTAPHVIERIHEA 61 Query: 58 YYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLL 117 Y +AGA T ++ AT L + L ++ LARKA +AY Sbjct: 62 YLQAGADIIETNTFGATNVVLDEYHLGHL-ALELNIEAARLARKAADAYSTPEW---PRF 117 Query: 118 VAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE 177 VAGS+GP L+ + E A + + LL G DLL ET + ++ Sbjct: 118 VAGSMGPTTKTLSVTG------GITFEQLVAAYEEQARGLLLGGVDLLLLETCQDTLNVK 171 Query: 178 A----LAELLTAYPR-ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IA 231 A +++ A + S T+ G + + + + A+G+NC Sbjct: 172 AGFIGISKAFEAVGKQVPIMISGTIEPMGTTLAGQTIESFFISV-QHMKPFAVGLNCATG 230 Query: 232 LENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG-AR 290 E T L+ L L + YPN+G + + E LA + ++ G Sbjct: 231 PEFMTDHLRALASLANTAVSCYPNAGLPDEEGC-----YHETPEMLAKKIRRFAEKGWIN 285 Query: 291 LIGGCCRTTPADIAALKA 308 ++GGCC TTP I A+ Sbjct: 286 IVGGCCGTTPEHIRAIAE 303 >UniRef50_D1B7X8 Homocysteine S-methyltransferase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B7X8_THEAS Length = 816 Score = 235 bits (601), Expect = 1e-60, Method: Composition-based stats. Identities = 87/306 (28%), Positives = 130/306 (42%), Gaps = 30/306 (9%) Query: 6 PLRALLDK-QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 +R+LL + + L++DG M T+L RG + ++ + P+ +REVH Y +GA Sbjct: 7 RVRSLLGEVRSPLVMDGGMGTQLAERG--WHPPMLPEEMCLHMPQAVREVHESYVESGAA 64 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP 124 T S+ + + RGL ++ L +S ++AR+A G LVAGSVGP Sbjct: 65 VLETNSFGGSVRKLSMRGLGHL-AEELALRSAQIARQAA----------GDALVAGSVGP 113 Query: 125 YGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNF-SEIEALAELL 183 G LA E S E P+V L+ GADL+ ET+ + A+ + Sbjct: 114 TGEMLAPLGE------MSFEEAVKSFEPQVRGLIRGGADLILIETMLDLKEAAAAVEAVK 167 Query: 184 TAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHL 242 P SFT GT + A A + +G NC + ++ L Sbjct: 168 RVDPLFPFVVSFTFDRDGRTVTGTTP-EAAACWAQAVGALGVGANCGLGPRGYVPVVRRL 226 Query: 243 HGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPAD 302 + LP+ VYPN+G + + AGA +IGGCC TTP Sbjct: 227 AEASPLPVWVYPNAGVPSAGDY-------LGPDEFVGECEELLKAGASVIGGCCGTTPDH 279 Query: 303 IAALKA 308 + AL A Sbjct: 280 VRALAA 285 >UniRef50_A3LQC9 AdoMet-homocysteine methyltransferase n=1 Tax=Pichia stipitis RepID=A3LQC9_PICST Length = 337 Score = 235 bits (600), Expect = 1e-60, Method: Composition-based stats. Identities = 98/333 (29%), Positives = 160/333 (48%), Gaps = 34/333 (10%) Query: 7 LRALLDKQDILLLDGAMATELEA------RGCNLADSLWSAKVLVENPELIREVHLDYYR 60 L+ L K L+LDGAM TELEA + LWS VL+ P LI+ VH +Y Sbjct: 4 LKEALSKNR-LVLDGAMGTELEACIPKDSKIQPRKHPLWSGLVLLNEPNLIKNVHYNYLE 62 Query: 61 -AGAQCAITASYQATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQAGT-LL 117 A I+++YQ + LD+ Q + + KS+++ A Y ++N + + Sbjct: 63 QADVDALISSTYQISYPSLKEHTDLDDEQIRGIWKKSIDVVEDAILQYRSKNSNSKKKIY 122 Query: 118 VAGSVGPYGAYLADGSEYRGDYHCSVE-AFQAFHRPRVEALL-DAGADLLACETLPNFSE 175 + GS+GPY YLADGSEY GDY + + +++H+P +E L D D + ET+P+F E Sbjct: 123 IIGSIGPYATYLADGSEYTGDYKNASDSDIESYHQPLLEYFLGDDRVDTIGFETIPSFQE 182 Query: 176 IEALAELL-----TAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQ--------V 222 ++ + +LL R + SF D ++DGTP V++ + + + Sbjct: 183 VKVVLKLLSHLFAEQEKRKYYYISFNF-DEATITDGTPTEVVISYIDSFLDKYPFLRKYM 241 Query: 223 VALGINCIALENTTAALQHLHGLTV------LPLVVYPNSGEHYDAVSKTWHHHGEHCAQ 276 V LG+NCI + + ++ PL+VYPN Y + + + + Sbjct: 242 VGLGLNCIDYHKIGSIVAKINDSQTSAQKPLFPLIVYPNFTIKYVPEEDDYRAY-KDIEK 300 Query: 277 LADYLPQWQAA-GARLIGGCCRTTPADIAALKA 308 + + +W R+IGGCC T+P +I ++ Sbjct: 301 WKELVSEWVTIPNVRMIGGCCSTSPKEIKEVRR 333 >UniRef50_C0D4W7 Putative uncharacterized protein n=3 Tax=Clostridium RepID=C0D4W7_9CLOT Length = 836 Score = 235 bits (599), Expect = 2e-60, Method: Composition-based stats. Identities = 78/312 (25%), Positives = 120/312 (38%), Gaps = 28/312 (8%) Query: 13 KQDILLLDGAMATELEARGCNLAD--SLWSAKVLVENPELIREVHLDYYRAGAQCAITAS 70 +Q L DG + L+A+G + +WS + PE+ ++H DY AGA T + Sbjct: 8 RQRRLFFDGGTGSLLQAQGLKAGELPEVWS----ITRPEVCVKLHRDYLEAGADIIKTNT 63 Query: 71 YQATPAGFA-----------ARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVA 119 + A F GL A A E+ A + +AG +A Sbjct: 64 FGANGLKFKGRENASGAQGPEAGLPAADRPADSYSVDEIVTAAMKNARRAVAEAGHGYIA 123 Query: 120 GSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEAL 179 +GP G L + EA ++ V GADL+ ET+ + E++A Sbjct: 124 LDLGPTGKLLKPLGDL------DFEAAVELYKEVVRIGRREGADLVLIETMSDSYELKAA 177 Query: 180 AELLTAYPRA-RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTA 237 + + L G + VALL G +V ALGINC + Sbjct: 178 VLAAKEAGEGLPVFATVVFDGKGKLLTGGNVESTVALLEGL-RVDALGINCGLGPVQMKG 236 Query: 238 ALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCR 297 ++ L ++ LP++V PN+G T + + A + + GA +GGCC Sbjct: 237 IVEELLKVSSLPVIVNPNAGLPRSENGVT--LYDIDGDRFAQVMEEIARMGACFLGGCCG 294 Query: 298 TTPADIAALKAR 309 TTP I R Sbjct: 295 TTPEHIQKTVGR 306 >UniRef50_Q30ZI4 Methionine synthase (B12-dependent) n=14 Tax=Desulfovibrionales RepID=Q30ZI4_DESDG Length = 841 Score = 234 bits (598), Expect = 3e-60, Method: Composition-based stats. Identities = 81/305 (26%), Positives = 116/305 (38%), Gaps = 23/305 (7%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 R L +L DGAM T L+ RG S + NP +++ VHLDY RAGA Sbjct: 35 FRRALSDDTLLFFDGAMGTMLQGRGLPAGMS--PEVFCLSNPAVLQGVHLDYARAGADVL 92 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 T ++ T G++ + + R A A T+ VAGSVGP G Sbjct: 93 TTNTFGGTRLKLPE-GMNVVEFNREMA---------RAAKAAAGQAGRTVFVAGSVGPTG 142 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 ++ + R ++ L+ G DL+ ET + +E+ A+ A Sbjct: 143 HFVKPLGDLEFS------ELVDIFREQIRGLVQGGIDLVLAETHFDLAEVRAVVLAARAE 196 Query: 187 PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGL 245 S T D GT V + V + NC E + L Sbjct: 197 CNLPVGVSMTFED-GVSLTGTRPEVFVHTMQNM-GVDLIATNCSAGPEQMAGVVAGLTAA 254 Query: 246 TVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAA 305 +P++V PN+G T G + A + AG R +GGCC TTP IAA Sbjct: 255 GDIPVLVMPNAGLPELENGNTVFRLG--PEEFAAQTADFVRAGVRCLGGCCGTTPDHIAA 312 Query: 306 LKARS 310 L + Sbjct: 313 LAREA 317 >UniRef50_D2RMA2 Homocysteine S-methyltransferase n=13 Tax=Bacteria RepID=D2RMA2_ACIFE Length = 805 Score = 234 bits (597), Expect = 3e-60, Method: Composition-based stats. Identities = 78/301 (25%), Positives = 117/301 (38%), Gaps = 20/301 (6%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 L + L DGAM T L+ G + + +PE +R +H Y RAG Sbjct: 3 FTEALHTRR-LFFDGAMGTMLQEAGLQPGE--LPETWNLLHPEKVRAIHQAYVRAGVDIL 59 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 T ++ A F A + + + L+ VE AR A A + VA +GP G Sbjct: 60 KTNTFGANGLKFGAAH-GQPEVEELVRAGVENARAAFAA------EVRDGFVALDLGPTG 112 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 L + A + +V+A AGADL+ ET+ + E +A Sbjct: 113 KLLQPFGDLPFA------EAVALYAAQVKAGAAAGADLILIETMSDSYEAKAAILAAKEN 166 Query: 187 PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGL 245 +FT + L +G + + ++A V A+G NC + + Sbjct: 167 ADLPIVCTFTFDEDGKLLNGADVTTAL-VMAESLGVSAVGFNCGQGPDTLVKLVPQALQA 225 Query: 246 TVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAA 305 +PLV PN+G KT H A + + AG ++GGCC TTP IA Sbjct: 226 VDIPLVANPNAGLPVQKDGKTVFHIDG--EGYAPLMVPFAEAGVSVLGGCCGTTPDHIAR 283 Query: 306 L 306 L Sbjct: 284 L 284 >UniRef50_B9DIA5 Methylenetetrahydrofolate reductase n=10 Tax=Staphylococcus RepID=B9DIA5_STACT Length = 613 Score = 234 bits (597), Expect = 3e-60, Method: Composition-based stats. Identities = 67/298 (22%), Positives = 117/298 (39%), Gaps = 28/298 (9%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K+++L+ DGA+ T L + G + + +P+ I ++H Y +AGA T +Y Sbjct: 9 KENVLVADGAIGTILYSEGIDT----CPEAYNITHPKKIEQIHRSYIQAGADVIQTNTYG 64 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY-GAYLAD 131 A GL E Q K + +V +A+KA + G+VG + G + Sbjct: 65 ANFEKLQTFGL-EHQVKDITRAAVRIAKKAANE---------DTFILGTVGGFKGVKQNE 114 Query: 132 GSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARA 191 S YH + +++ L+D G D L ET + +E+ + Sbjct: 115 LSLSTILYHTDI---------QIDTLIDEGVDALLFETYYDLNELLQVIRATKKKYDIPV 165 Query: 192 WFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPL 250 T ++ +L DGT + + + + +G+NC + + H+ L Sbjct: 166 IAQLTASNTNYLQDGTEINEALKQVEA-EGADVIGLNCHHGPHHMQQSFTHIELPQHALL 224 Query: 251 VVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 YPN+ + + ++ + G LIGGCC TTP I +K Sbjct: 225 SCYPNA--SLLDFENSSIKYSDNASYFGKIAKSLVKEGVHLIGGCCGTTPEHIHYIKE 280 >UniRef50_B2A781 Homocysteine S-methyltransferase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A781_NATTJ Length = 793 Score = 232 bits (592), Expect = 1e-59, Method: Composition-based stats. Identities = 65/293 (22%), Positives = 126/293 (43%), Gaps = 26/293 (8%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 + +L LDG+ TEL+ RG + + +++ +L++ VH DY AGA +T ++ Sbjct: 13 EKLLFLDGSYGTELQRRGFEGNAEI----LNLQDQDLVKNVHYDYASAGADLILTNTFGG 68 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 G E + + + VELA+++ E +LV G + G ++ Sbjct: 69 NRLKLKDAGY-EDKVAEINSRGVELAKESAENI------DRDVLVVGDISSTGRFIEPVG 121 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE-ALAELLTAYPRARAW 192 + S Q + + L+++G DL+ ET+ + E++ A+ + + Sbjct: 122 DL------SFTKAQQVFQEQGRYLIESGVDLIKIETMTDIKELKAAILGIRSIDEDLPLI 175 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLV 251 S + GT + V L+ P V +G+NC + ++ ++ ++ PL Sbjct: 176 VSMSFEQDGKTITGTSVPSYVTLMNDLP-VDIIGLNCGVKSKDMLDLVKQASYYSLKPLS 234 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG-ARLIGGCCRTTPADI 303 + PN+G+ +S + E + + YL ++GGCC TTP + Sbjct: 235 ISPNAGDPDLDLS-----YSEDPQEFSFYLDAISDLDMVAIVGGCCGTTPEYV 282 >UniRef50_A7VWF8 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753 RepID=A7VWF8_9CLOT Length = 408 Score = 232 bits (591), Expect = 1e-59, Method: Composition-based stats. Identities = 72/293 (24%), Positives = 122/293 (41%), Gaps = 23/293 (7%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 L+LDGA T L A G + + ++E+PE + + + AG+ + ++ A Sbjct: 8 PLILDGATGTNLIAAGMP--SGVCVEQWILEHPEKLLALQRAFLEAGSNAVMAPTFGANR 65 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 AA GL + Q + + K V L+++A E + LV G V P G + + Sbjct: 66 EKLAAYGLQD-QVEEINLKLVALSKEAAEPF--------HALVGGDVSPAGVMIEPYGDL 116 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 D + ++ AL AG D +A ET + +++ A + + Sbjct: 117 TFD------ELYDIYLEQIRALKKAGVDFIALETQMSLADLRAGVLAAKEA-GLPVFATI 169 Query: 196 TLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLVVYP 254 T+ D+ GT V+ L A+G+NC E L+ +PL+ P Sbjct: 170 TVEDNGRTIMGTKFLPVLITLQALGAA-AVGLNCSTGPEVMEELLEGAVSHAQVPLIAKP 228 Query: 255 NSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 N+G+ + A+ A+ + AAGA+++GGCC +TP I L Sbjct: 229 NAGKPSQEDPAVY---PLSPAEFAEKMESLLAAGAQIVGGCCGSTPEHIRELA 278 >UniRef50_Q024B4 Homocysteine S-methyltransferase n=2 Tax=Bacteria RepID=Q024B4_SOLUE Length = 304 Score = 232 bits (591), Expect = 2e-59, Method: Composition-based stats. Identities = 70/315 (22%), Positives = 120/315 (38%), Gaps = 29/315 (9%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 N PL+ ++ ++ LL DGAM T+L G + + +PE + + Y AG Sbjct: 1 MNEPLQDVI-RRRPLLGDGAMGTQLMFAGLEQGN--CGELWNLTHPERVLGIQRRYAEAG 57 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 + C +T ++ + G + + +VE+AR+A V G + Sbjct: 58 SDCILTNTFGGSRIMLNRHG-SSGKVVEINRAAVEIAREAF--------GGRAGYVIGDI 108 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP+G + ++ E ++ + AL+DAGAD + ET + E++ E Sbjct: 109 GPFGGLMQPYGDFT------EEDVRSAFGEQAGALVDAGADAIIIETQTSLEELQLGIEA 162 Query: 183 LTAYPRARAWFSFTLR-----DSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENT-- 235 S + G + + + +NC + Sbjct: 163 AREAGAPCVIGSMAYDVTLDGSTFRTMMGVDPERAAGFMQEH-DADIVALNCGTGMDMAR 221 Query: 236 -TAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGG 294 A+ T LP++V PN+G K + E Q+A + AGA +IG Sbjct: 222 AREAVLRYRKATDLPVMVQPNAGVPKLISMKVV--YDETPEQMASGVAPLLCAGANIIGA 279 Query: 295 CCRTTPADIAALKAR 309 CC +TP I A +A Sbjct: 280 CCGSTPEHIRAFRAE 294 >UniRef50_Q1NSQ8 Methylenetetrahydrofolate reductase n=3 Tax=Deltaproteobacteria RepID=Q1NSQ8_9DELT Length = 704 Score = 232 bits (591), Expect = 2e-59, Method: Composition-based stats. Identities = 71/300 (23%), Positives = 123/300 (41%), Gaps = 23/300 (7%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 ++ ++L DGA+ T L ++G L + ++ + +P+LI +H +Y RAG+Q T ++ Sbjct: 85 QEKVILGDGAIGTYLYSKGIELGKD--TDRLNLSDPDLIYSLHEEYIRAGSQLIETNTFG 142 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A A GL E Q++ + +A++A + VAGSVGP G Sbjct: 143 ANRLKLLANGL-ENQAREINLAGAGIAKRAA---------GEDIYVAGSVGPTGVEFPLE 192 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY-PRARA 191 + A + ++ ALL+A DLL ET + E+ E P+ Sbjct: 193 A-----GEIEPAEVAAAYEEQISALLEAEVDLLILETFTHLDELLIALETARRLAPQHPI 247 Query: 192 WFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTV-LP 249 + G + +G NC + + A++ L L +P Sbjct: 248 VAQMAYPAQGRTARGDHALTCGTAAIAAGASL-VGANCGRGVNSMLTAIEALSPLRDQVP 306 Query: 250 LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKAR 309 L +PN+G + + +A + + GARL+GGCC T+P I + + Sbjct: 307 LSAFPNAGFPEIVGHR--MIYPAQPEYMARVVGEMIKLGARLVGGCCGTSPTHIQEFRKQ 364 >UniRef50_B8J7W9 Methionine synthase n=3 Tax=Anaeromyxobacter RepID=B8J7W9_ANAD2 Length = 1150 Score = 231 bits (590), Expect = 2e-59, Method: Composition-based stats. Identities = 73/310 (23%), Positives = 128/310 (41%), Gaps = 22/310 (7%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLAD----SLWSAKVLVENPELIREVHLDYYRAG 62 R L+ + L+ DGAM T+++ A+ + + + P+LI E+H Y+ G Sbjct: 3 FREALE-RRPLVFDGAMGTQIQRHQLTAAEFGGKEGANDLLTLTRPDLIEEIHARYFAVG 61 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 T ++ ++ GL ++ + ++ LAR+A + Y + VAGS+ Sbjct: 62 CDVVETNTFGSSRLKLDEYGLGH-RTYEVNCRAAILARRAADRYSTPD---HPRFVAGSI 117 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G + S + + +A + + + L++ G D L ET + E+ A Sbjct: 118 GPTG--MLPSSSDPALGNITSDALERIFFEQAKGLVEGGVDALIIETQQDMLELRAAVLA 175 Query: 183 LT-----AYPRARAWFSFTLRD-SEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENT 235 A TL D + + GT + VA L P V A+G+NC + Sbjct: 176 CDAVRREALRDVFVIAQPTLIDANGRMLLGTDIGSAVATLERLP-VDAVGLNCSTGPDEM 234 Query: 236 TAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ-AAGARLIGG 294 A+++ L + V PN+G + + + LA L + G ++GG Sbjct: 235 RASVKALAEKCSHFVSVLPNAGMPENVDGRAVYK--LSPDDLARALVGFVAEYGVDIVGG 292 Query: 295 CCRTTPADIA 304 CC TTP + Sbjct: 293 CCGTTPEHLR 302 >UniRef50_B2UNQ8 Methionine synthase n=1 Tax=Akkermansia muciniphila ATCC BAA-835 RepID=B2UNQ8_AKKM8 Length = 1253 Score = 231 bits (590), Expect = 2e-59, Method: Composition-based stats. Identities = 81/359 (22%), Positives = 140/359 (38%), Gaps = 58/359 (16%) Query: 2 SQNNPLRALLD--KQDILLLDGAMATELEA--------RGCNLADSLW--------SAKV 43 S+ L L D ++ +++LDGAM T ++ RG AD+ + + Sbjct: 5 SRTERLDYLKDQLRKRVVILDGAMGTNIQKFRLGEGDYRGERFADAECYPNDLKNNNDLL 64 Query: 44 LVENPELIREVHLDYYRAG-AQCAITASYQATPAGFAAR-------GLDEAQ-------- 87 ++ P++I ++H + G T ++ AT G G + Q Sbjct: 65 VLTRPDIILDIHRRFLDTGRTDILETCTFGATSIGQHDYFWHRPEEGSHKDQQYFQEVVD 124 Query: 88 -------SKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY--LADGSEYRGD 138 + L + LAR+A + AE LVAGS+GP L+ G Sbjct: 125 APELKALVRELNLAAAALARQACDE--AEAADGKPRLVAGSIGPMPVTCSLSPDVNDPGF 182 Query: 139 YHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA----ELLTAYPR--ARAW 192 + + +R +V ALL+ G D+L ET+ + +A E+ P Sbjct: 183 RAVNFRQLRQAYRDQVLALLEGGVDMLLVETIFDTLNAKAALFAIEEIFEEQPESSVPVM 242 Query: 193 FSFTLRD-SEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPL 250 S TL D + G + + + + ++GINC + + + L GL + Sbjct: 243 VSVTLTDKAGRTLSGQTI-EAFWNSIRHVRPFSVGINCALGPDLMRPFAEELSGLADCHM 301 Query: 251 VVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG-ARLIGGCCRTTPADIAALKA 308 +Y N+G + A +A ++ ++ G ++GGCC TTP I A+ A Sbjct: 302 SIYANAGLPNPLSP---TGYDLLPADMARFMKEYAEQGLLNIVGGCCGTTPEHIGAIAA 357 >UniRef50_UPI000196BD90 hypothetical protein CATMIT_02259 n=1 Tax=Catenibacterium mitsuokai DSM 15897 RepID=UPI000196BD90 Length = 791 Score = 231 bits (590), Expect = 2e-59, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 118/298 (39%), Gaps = 25/298 (8%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 + L K+ L DG + L++ G + + +PE I E++ Y AG Sbjct: 3 FKERLTKE-WLFWDGGTGSVLQSWGLQAGE--LPETWNIIHPEKIVELNKGYLEAGCDII 59 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 T ++ A + + ++ K+VE A+KAR E L+A +GP G Sbjct: 60 NTNTFGANRLKYPDN------LEEIVTKAVEHAKKAR-----ELTGRADALIALDLGPTG 108 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 L + S + + +E AGAD++ ET+ + E++A + Sbjct: 109 KLLEPLGDL------SFDDAVDIYAEVIEYGTKAGADVILIETMQDSYELKAAVLAAKEH 162 Query: 187 PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGL 245 + + + G VVALL G + ALGINC ++ + + Sbjct: 163 SDLPVCATVVFDEKGKMLTGGTPESVVALLEGLH-IDALGINCSLGPRQIKPFVERMIQV 221 Query: 246 TVLPLVVYPNSGEHY-DAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPAD 302 + P++V PN+G D T++ A + + + ++GGCC TTP Sbjct: 222 SSTPIIVTPNAGLPQTDDEGHTYYDM--SADDFALEMKEIASLNVHVLGGCCGTTPEY 277 >UniRef50_Q8DUN2 Methylenetetrahydrofolate reductase n=12 Tax=Streptococcus RepID=Q8DUN2_STRMU Length = 618 Score = 231 bits (589), Expect = 3e-59, Method: Composition-based stats. Identities = 79/308 (25%), Positives = 121/308 (39%), Gaps = 29/308 (9%) Query: 7 LRALLDK--QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 + LLDK DIL+ DGAM T L A G + + +PE I +H Y AGA Sbjct: 1 MSRLLDKLKTDILVADGAMGTLLYADGLESCHEYY----NISHPERILAIHQAYIAAGAD 56 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP 124 T +Y A + G D+ + KA+ +V LAR+A V G++G Sbjct: 57 IIQTNTYGAKRHRLKSFGHDK-EVKAINQAAVHLARQAA---------GDNTFVLGTIG- 105 Query: 125 YGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAG-ADLLACETLPNFSEIEALAELL 183 S S+E + + LL+ D L ET + E+EA + L Sbjct: 106 -------ASHGLKHCELSLEDIISQTVEQARFLLETKQIDGLLLETYYDIEELEAALKAL 158 Query: 184 TAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHL 242 + L + +G PL + + L +G+NC + + + + + Sbjct: 159 RPLTDLPIITNVALHEPGITENGRPLVEAFSNLV-MLGADIVGLNCHLGPYHMIQSFKQV 217 Query: 243 HGLTVLPLVVYPNSGE--HYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 L YPN+ ++T +H ++ + G RLIGGCC TTP Sbjct: 218 PLFAQSYLSAYPNASLLSFSSDDNETPYHFSQNADYFEYCAKLFVEEGVRLIGGCCGTTP 277 Query: 301 ADIAALKA 308 I A+K Sbjct: 278 EHIKAIKR 285 >UniRef50_B7GLS5 Methionine synthase I containing methyltransferase and cobalamin-binding domains n=1 Tax=Anoxybacillus flavithermus WK1 RepID=B7GLS5_ANOFW Length = 1142 Score = 231 bits (589), Expect = 3e-59, Method: Composition-based stats. Identities = 73/309 (23%), Positives = 120/309 (38%), Gaps = 29/309 (9%) Query: 13 KQDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREVHLDYYRAGAQCA 66 ++ IL++DGAM T ++A D + + + P +I +H Y+ AGA Sbjct: 22 EKKILIIDGAMGTMIQAANLTADDFGGEAYEGCNEYLTLTAPHVISHIHEAYFAAGADIV 81 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 T ++ AT L + L ++ +LA++A E Y VAGS+GP Sbjct: 82 ETNTFGATRIVLDEYNLGHL-ALELNMEAAKLAKRAAEKYT---TSDHPRFVAGSMGPTT 137 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEAL-----AE 181 L+ + + + + LL G DLL ET + ++A Sbjct: 138 KTLSVTG------GATFAELISSYEEQARGLLLGGVDLLLLETCQDTLNVKAAFLGITKA 191 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQ 240 + S T+ G + + + + A+G+NC E T L+ Sbjct: 192 FQAVGKQVPLMISGTIEPMGTTLAGQTIESFFISV-QHMKPFAIGLNCATGPEFMTDHLR 250 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG-ARLIGGCCRTT 299 L L + YPN+G + H+ E LA + Q+ G ++GGCC TT Sbjct: 251 SLASLANTAVSCYPNAGLPDEEG-----HYHETPEMLAKKIRQFAEKGWLNIVGGCCGTT 305 Query: 300 PADIAALKA 308 P I A+ Sbjct: 306 PQHIQAIAE 314 >UniRef50_Q1AXR8 Methylenetetrahydrofolate reductase n=2 Tax=Bacteria RepID=Q1AXR8_RUBXD Length = 611 Score = 230 bits (587), Expect = 4e-59, Method: Composition-based stats. Identities = 85/305 (27%), Positives = 127/305 (41%), Gaps = 22/305 (7%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 R LLD +L+ DGAM T L RG A+ + +PEL+ +H +Y RAGA+ Sbjct: 3 TSFRDLLD-GRVLVGDGAMGTLLADRGVGYGHPY--ARANLTHPELVERLHGEYVRAGAR 59 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP 124 T ++ A A L+E + + + R A A A +LV G++GP Sbjct: 60 AIETNTFSANRIKLAGHRLEE-RVREINEAGA------RLARRAAAEAAERVLVLGAIGP 112 Query: 125 YGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 G LA E +A R + EALL+ G+D L ET + E+ E + Sbjct: 113 LGRPLAPVG------RVPREEARALFREQAEALLEGGSDALLLETFTDLEELRLAWEAVR 166 Query: 185 AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLH 243 + + D E L++G P ++G+ V +G NC + ++ + Sbjct: 167 DLGAPVLAYKTFVEDGETLAEGLP-ERAAREISGW-GVELVGSNCTVGPQRMLGIVEQMS 224 Query: 244 GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADI 303 P+ +PN G + H A Y + AGAR +GGCC TTP I Sbjct: 225 AAAG-PVAAFPNPGLPQLVEGTVRYSHD--VEHFARYGLRLAEAGARFVGGCCGTTPEHI 281 Query: 304 AALKA 308 AL Sbjct: 282 RALSE 286 >UniRef50_C0QE32 Methionine synthase I, cobalamin-binding domain protein n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QE32_DESAH Length = 294 Score = 230 bits (586), Expect = 7e-59, Method: Composition-based stats. Identities = 77/301 (25%), Positives = 123/301 (40%), Gaps = 21/301 (6%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K LL DG M + L ARG D+ + + PE I+EVH YY+AGA A T ++ Sbjct: 8 KTRGLLFDGGMGSMLIARGLQGGDA--PERWNLTRPEAIQEVHQAYYKAGADMATTNTFG 65 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A+ A + E + + V++A+ A+E + +AG +G G LA Sbjct: 66 ASAIKLAKMAVTEGM-EEINRAGVKVAKDAKEVW------GPGKFIAGDIGEAGDMLAPM 118 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 S E QA + + E L AG D+ ET + + A + + Sbjct: 119 GPL------SQEDAQACFKEQAEVLAHAGVDIFIIETQFDLNMALAAIRGIRSVTDIPIA 172 Query: 193 FSFTLRD---SEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVL 248 + T + G P + + LAG V +G NC + + Sbjct: 173 CTMTFKQTPKGFFTIMGNPPAESMKTLAGEGAFV-VGANCSMGSDTMVELAGVIRDAVDT 231 Query: 249 PLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 P+++ PN+G +T + E AD + + ++ G ++GGCC TTP I + Sbjct: 232 PVMIQPNAGMPQAGPDQTV-TYPETADFFADNIMKMKSLGIEVVGGCCGTTPDYIRTIHD 290 Query: 309 R 309 R Sbjct: 291 R 291 >UniRef50_Q15S12 Homocysteine S-methyltransferase n=1 Tax=Pseudoalteromonas atlantica T6c RepID=Q15S12_PSEA6 Length = 304 Score = 229 bits (585), Expect = 9e-59, Method: Composition-based stats. Identities = 80/302 (26%), Positives = 126/302 (41%), Gaps = 24/302 (7%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 I +LDG M EL R +WSA +++ PEL+R++H ++ +GA+ +Y ATP Sbjct: 12 ITILDGGMGQELLRRSSRDVTPMWSADIMLNEPELVRDLHREFINSGARVITLNTYTATP 71 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 E Q L ++ A++A Q +++AGS+ P A Y Sbjct: 72 QRLKRENQFE-QFVHLHDAAMRAAQEAIAL-----TQRDDVMIAGSLPPLVA------SY 119 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 + S E +R ++ AL G+D+ CET+ + E +A W +F Sbjct: 120 HPEVSLSFEDSLVSYR-QLVALQSLGSDIFICETMSSICEAQAACTAAKE-SGKPVWVAF 177 Query: 196 TLRDSE--HLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVY 253 T+ D+E L G L+D + L A+ +NC E +A L + + Y Sbjct: 178 TVSDTEPDQLRSGELLKDALDALKALS-PDAIMLNCSLPEAI-SACWSLMQQSNAKIGAY 235 Query: 254 PN------SGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 N + D V + Q A + W GA +IGGCC P I AL Sbjct: 236 ANGFVSIDALYPGDTVEELEMRKDMSPEQYAAHAMHWVQNGASIIGGCCEIGPDHIKALH 295 Query: 308 AR 309 ++ Sbjct: 296 SK 297 >UniRef50_B4RRL7 Homocysteine S-methyltransferase family protein n=1 Tax=Alteromonas macleodii 'Deep ecotype' RepID=B4RRL7_ALTMD Length = 305 Score = 228 bits (582), Expect = 2e-58, Method: Composition-based stats. Identities = 87/308 (28%), Positives = 128/308 (41%), Gaps = 28/308 (9%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 + I +LDG M EL+ G WSA L+++PEL+ +VH + AGA T +Y Sbjct: 6 KAIQILDGGMGRELKKIGAPFRQPEWSALALMQSPELVSDVHTHFLNAGATVITTNTYAL 65 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP-YGAYLADG 132 P + +E Q+ L + +LAR A A ++ Q G L VAG + P +G+Y D Sbjct: 66 VPFHIGEQTFNE-QAFKLAETAAKLARDAVNA--QQDKQEGNLSVAGCIPPAFGSYRPDL 122 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 D E P +EA D+ ET + E EA+ L+ W Sbjct: 123 ----FDASRVSEILM----PLIEA-QAPYIDVWLIETASSIEEAEAVVSLIKTLSSRPIW 173 Query: 193 FSFTLRDSE------HLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLT 246 SF+L + L G PL +V +L +V+ NC E +A+ L Sbjct: 174 LSFSLHNRASTDEPVTLRSGEPLEKIVPVLRDVERVL---FNCSQPEEMESAITITRKLN 230 Query: 247 -VLPLVVYPNSGEHYDAVSK-----TWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 + + Y NS + + A+ DY+ W AAGA +GGCC P Sbjct: 231 PNIAIGAYANSFSERKRSHQANALLSELRDDVTPARYLDYVKSWIAAGASTVGGCCGIGP 290 Query: 301 ADIAALKA 308 I A+ Sbjct: 291 EHIKAISE 298 >UniRef50_C6VPC5 Methylenetetrahydrofolate reductase n=3 Tax=Lactobacillus plantarum RepID=C6VPC5_LACPJ Length = 618 Score = 228 bits (581), Expect = 2e-58, Method: Composition-based stats. Identities = 73/305 (23%), Positives = 120/305 (39%), Gaps = 25/305 (8%) Query: 13 KQDILLLDGAMATELE-ARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 +Q +L+ DGAM T L G N A + + +P+ I VH Y RAGA T +Y Sbjct: 8 QQRVLVADGAMGTLLYGNYGINSAF----ENLNLTHPDTILRVHRSYIRAGADIIQTNTY 63 Query: 72 QATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLAD 131 A L + Q + +V++A ARE + + G++G Sbjct: 64 AANRLKLTRYDLQD-QVTTINQAAVKIAATAREH------ADHPVYILGTIGGLA----- 111 Query: 132 GSEYRGDYHCSVEAFQAFHRPRVEALLDAG-ADLLACETLPNFSEIEALAELLTAYPRAR 190 G + A ++ ALL D + ET + E+ A +++ A+ Sbjct: 112 GDTDATVQRATPATIAASVTEQLTALLATNQLDGILLETYYDLPELLAALKIVKAHTDLP 171 Query: 191 AWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLP 249 + ++ L +GT D + L +G NC + + ++L + Sbjct: 172 VITNVSMLAPGVLRNGTSFTDAIVQLNA-AGADVIGTNCRLGPYYLAQSFENLAIPANVK 230 Query: 250 LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPAD----IAA 305 L VYPN+G + GE + +Y +++ G +IGGCC TTP + Sbjct: 231 LAVYPNAGLPGTDQDGAVVYDGE-PSYFEEYAERFRQLGLNIIGGCCGTTPLHTSATVRG 289 Query: 306 LKARS 310 L RS Sbjct: 290 LSNRS 294 >UniRef50_C7N1R7 Methionine synthase (B12-dependent) n=5 Tax=Bacteria RepID=C7N1R7_SLAHD Length = 820 Score = 227 bits (578), Expect = 6e-58, Method: Composition-based stats. Identities = 71/308 (23%), Positives = 114/308 (37%), Gaps = 27/308 (8%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRA 61 +++ L A+L + L+ DGAM T L+A G + + + +P + +H Y A Sbjct: 19 TKDEYLAAVLRGEAYLVFDGAMGTMLQASGMEAGE--LPELLCLTDPAGVTAIHRQYVEA 76 Query: 62 GAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGS 121 G+Q T ++ A D A + + +V AR+ +G VAG Sbjct: 77 GSQAITTNTFGANARKLG----DAATVEDVFAAAVACARE-----------SGARYVAGD 121 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 +GP G L S + V A AGADLL ET+ + E++A Sbjct: 122 IGPTGGLLEPLG------TMSFDEAYDLFAQEVRAADAAGADLLVIETMADLLEMKAAVL 175 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQ 240 + + T + GT + L V LG+NC + + Sbjct: 176 AAKENSDLPIFATMTFGEDGRTFLGTSPQIAALTLDAL-GVNVLGVNCSLGPSDLQPIVS 234 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 + P++ N+G T + + A+ + G +IGGCC T P Sbjct: 235 AMLETATCPVMAQANAGLPSVVDGHTVYSIM--PDEYANAVQAMVDEGVSVIGGCCGTNP 292 Query: 301 ADIAALKA 308 I L A Sbjct: 293 DYIRQLAA 300 >UniRef50_D0LSQ2 Methylenetetrahydrofolate reductase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LSQ2_HALO1 Length = 643 Score = 226 bits (577), Expect = 7e-58, Method: Composition-based stats. Identities = 80/309 (25%), Positives = 128/309 (41%), Gaps = 24/309 (7%) Query: 1 MSQNNPLRALLDK--QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDY 58 MS + L+ L+ Q LL DGAM + L RG + ++ + P+LIR VH +Y Sbjct: 1 MSGTSCLKPFLEALAQGPLLFDGAMGSLLYDRGVFHTRNY--DELSLSQPKLIRAVHREY 58 Query: 59 YRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLV 118 AGAQ T ++ A A G E + + +VE+AR + V Sbjct: 59 LEAGAQILETNTFGANRIKLTAHGHSE-RVADINRAAVEMARSVADD---------RAYV 108 Query: 119 AGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 AG+VGP G Y + +++ L++AG DLL ET E+EA Sbjct: 109 AGAVGPTGIR------YTIAPAAERKRAIEALGEQIDYLVEAGVDLLCLETFGAILELEA 162 Query: 179 LAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTA 237 EL + + D++ L +G VA A+G NC + A Sbjct: 163 AIELARQIAPEMPVVAHLVFDADGLVEGELDGATVAQRLIAAGANAVGANCGVGPPELYA 222 Query: 238 ALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCR 297 + + P+ + PN+G + +T + + + + +G R++GGCC Sbjct: 223 VGTKMSDVGA-PVSIQPNAGFPSNIDGRTIYV--ANPEHFGVFARRMLKSGVRMVGGCCG 279 Query: 298 TTPADIAAL 306 TTP + A+ Sbjct: 280 TTPEHVRAM 288 >UniRef50_C8WWX3 Methylenetetrahydrofolate reductase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WWX3_ALIAD Length = 637 Score = 225 bits (575), Expect = 1e-57, Method: Composition-based stats. Identities = 68/300 (22%), Positives = 115/300 (38%), Gaps = 31/300 (10%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 ++ DGAM+T L G + + ++ + +P+L+ VH Y +G T ++ Sbjct: 20 VIFDGAMSTYLHQLGVPIGTPV--EQLNLTSPDLVARVHRRYVESGCTVLQTNTFMGNRI 77 Query: 77 GFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP------YGAYLA 130 GL ++L + VE+AR A V G++GP YGA L Sbjct: 78 ALERHGLT-VDVQSLNRRGVEIARSAA---------RDEASVYGTMGPAMGGYRYGALLQ 127 Query: 131 DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE-IEALAELLTAYPRA 189 D + + + EAL+ AG D L ET P+ E + A+A + Sbjct: 128 D---------EERDLLARVYAEQAEALVSAGIDGLILETFPDLEEALVAIAAVRPILGDL 178 Query: 190 RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVL 248 + + + DG PL + + +G+NC + + + Sbjct: 179 PLVVNLSPEEIGVTRDGVPLAEAFRRIKA-AGADVVGLNCRLGPYGILRSYEQAGVAADG 237 Query: 249 PLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 P PN+G + + G+ A + + + G R +GGCC TTP I L+ Sbjct: 238 PYAAVPNAGILQRSEGDEIAYTGDT-ADFSRLMLRIAQLGVRWLGGCCGTTPEYIRTLRD 296 >UniRef50_A6DGP4 5-methyltetrahydrofolate--homocysteine methyltransferase n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DGP4_9BACT Length = 1204 Score = 225 bits (574), Expect = 2e-57, Method: Composition-based stats. Identities = 79/333 (23%), Positives = 136/333 (40%), Gaps = 46/333 (13%) Query: 13 KQDILLLDGAMATELEARGCNLADSLW--------SAKVLVENPELIRE-VHLDYYRAGA 63 K+ IL+LDGAM + ++ L DS + S ++ P+ +R+ +HL+Y +AGA Sbjct: 8 KEQILVLDGAMGSMVQL--LKLPDSAYGGEEYAMLSDLLVFSRPDQVRDNIHLEYLKAGA 65 Query: 64 QCAITASYQATPAGFAARGLD-----------------EAQSKAL----IGKSVELARKA 102 T ++ A+P E AL + +ELA+ A Sbjct: 66 NILETNTFGASPLRLQEFDFSKMDLSDFADLPEGLDFLENDYYALTHYFNIRGIELAQDA 125 Query: 103 REAYLA-ENPQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAG 161 E Y + L VAGS+GP ++ + + +V+A++ A Sbjct: 126 IEKYKKMDEYDGRPLFVAGSIGPSNWVISSTAANLNK--TDFATIKQNFYLQVKAMMQAN 183 Query: 162 ADLLACETLPNFSEIEA-LAELLTAYP----RARAWFSFTLRDSEHLSD-GTPLRDVVAL 215 D+L ET + E++A +A A + T+ + T + A Sbjct: 184 VDVLLFETQQDMLELKASIAGAHQAAEELGFKVPIMAQVTVDQFNKMQIFNTDMEAAYAA 243 Query: 216 LAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHC 274 + G + GINC E + L ++ LP+ V PN+G+ +T + Sbjct: 244 VGGI-GIDVFGINCTLGPELMQKVIPALAQMSELPISVVPNAGQPISVNGETVYPLA--P 300 Query: 275 AQLADYLPQW-QAAGARLIGGCCRTTPADIAAL 306 ++ +Y+ + G ++GGCC TTPA IA + Sbjct: 301 EKMGEYMRDYEAENGINIVGGCCGTTPAHIAEI 333 >UniRef50_A1SWN6 Homocysteine S-methyltransferase n=1 Tax=Psychromonas ingrahamii 37 RepID=A1SWN6_PSYIN Length = 310 Score = 225 bits (574), Expect = 2e-57, Method: Composition-based stats. Identities = 86/314 (27%), Positives = 130/314 (41%), Gaps = 42/314 (13%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 ++LDG M EL+ G WSA+ L+E+P I EVH + AGA+ T +Y P Sbjct: 16 PIILDGGMGRELKRIGAPFQQPEWSAQALIESPHFISEVHKSFIEAGAEVITTNTYALVP 75 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 + +E Q LI + LAR+ + A +LVAG + P Y Sbjct: 76 FHIGEKRFNE-QGADLIKLAARLARECVKENSA-------VLVAGCIPPV------LGSY 121 Query: 136 RGDYHCSVEAFQAFHRPRVEALL---DAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 R D +A +P +E L+ +A D+ ET+ + +E A+ + T W Sbjct: 122 RPDLFSVEKA-----KPVLELLIKNQEADVDIWLAETISSIAEA-AMIKARTVVTNKPTW 175 Query: 193 FSFTLRDSEH----LSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL--- 245 +FT++D L G + D V+ +AG V A+ NC +E AL Sbjct: 176 IAFTIKDEITTEPALRSGESVYDAVSQIAGQ-NVSAILFNCSGVEVMETALITAKQALLD 234 Query: 246 ----TVLPLVVYPNSGEHYDAVSKTWHHHGEH-------CAQLADYLPQWQAAGARLIGG 294 + L VY N+ + + HG + ++ W AGA +IGG Sbjct: 235 KEIEDQVQLGVYANNFPPIGELHQANQDHGVSGIRDDVPPEKYHEFGLSWINAGASIIGG 294 Query: 295 CCRTTPADIAALKA 308 CC +PA I L Sbjct: 295 CCGVSPAHIKKLAE 308 >UniRef50_D1N227 Methylenetetrahydrofolate reductase n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N227_9BACT Length = 605 Score = 225 bits (573), Expect = 2e-57, Method: Composition-based stats. Identities = 78/299 (26%), Positives = 129/299 (43%), Gaps = 29/299 (9%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 + + + DGA+ TE+ R + S ++ + P++I ++H Y +AGA+ T +Y A Sbjct: 10 ESLTIFDGAIGTEIYRRNFFVNASF--EQLNLTAPDVILDIHHQYLKAGAEVLTTNTYNA 67 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 A GL E Q++A+ V+LAR+A SVGP G Sbjct: 68 NSRRLAKFGLSE-QTEAINRAGVKLAREAAAGKALVAA---------SVGPVG------- 110 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWF 193 D ++ AL D AD + E+L ++++A+ E + +P Sbjct: 111 --EPDSDQDRRTRAELLAEQIRALSD--ADFIIFESLRRAADLKAVLEAVAEFPELVYVP 166 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAG---YPQVVALGINC-IALENTTAALQHLHGLTVLP 249 SF + H++D + + + L P A+G+NC E+T L+ L LT LP Sbjct: 167 SFAIEPHPHINDSATIAEFMEQLNASRPCPAPTAIGLNCGGGPESTLGVLEELTALTQLP 226 Query: 250 LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 ++V PN+G+ + + + Y ++ GA IGGCC TP I L Sbjct: 227 VIVQPNAGQPKGVDGR--MIYMTSAEYFSTYAKRYAMLGAAAIGGCCGITPDHIEELAR 283 >UniRef50_B1H0N5 Homocysteine S-methyltransferase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=B1H0N5_UNCTG Length = 801 Score = 225 bits (573), Expect = 2e-57, Method: Composition-based stats. Identities = 70/305 (22%), Positives = 117/305 (38%), Gaps = 23/305 (7%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 +L K IL++DGA TEL+ + L ++ ++ PE I +++ Y AG Sbjct: 2 NKQKFLDIL-KSRILIMDGATGTELQKKKY-LDGVEIPEEINIKFPERIADIYSSYINAG 59 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 + + ++ A GL ++ +I ++L R+ + +VAG + Sbjct: 60 SDIILANTFGANLIRLKQHGL-LDKADDIIKSGIDLIRE----------ISSDTIVAGDI 108 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 G Y+ D EA+ +F +V L GAD++ ET+ E +A Sbjct: 109 SSIGEYIEPLGSLTFD-----EAYNSF-AFQVSLLQKHGADVIVIETMTEIKETKAAILA 162 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQH 241 T GT L+ +A+ V ALG+NC + + Sbjct: 163 AKENFDGAIIVQMTFSKDGVTVTGTDLKSFIAMAESL-GVDALGLNCSIGSRDLAELAKV 221 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 L T LP+ PN+G +T E + + + + G + GGCC T P Sbjct: 222 LCVNTNLPISFKPNAGIPVLINRETC--FPETKEEFIEASLKAYSYGVNMFGGCCGTNPE 279 Query: 302 DIAAL 306 I L Sbjct: 280 FIKIL 284 >UniRef50_C6LEJ3 Vitamin B12-dependent methionine synthase family protein n=3 Tax=Clostridiales RepID=C6LEJ3_9FIRM Length = 291 Score = 224 bits (571), Expect = 3e-57, Method: Composition-based stats. Identities = 72/310 (23%), Positives = 129/310 (41%), Gaps = 24/310 (7%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M++ R L +DI++LDGA + L G + + + ++EN + + E+ Y Sbjct: 1 MTKKE-FRKL--AEDIIILDGATGSNLMKAGMP--RGICTEQWILENEQTLIELQRAYVE 55 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AG+Q ++ A AA GL + + + + V+++ +A E G VAG Sbjct: 56 AGSQIVCAPTFGANCRNLAAHGLRDKLA-DMNKRLVDISLRATE---------GRAYVAG 105 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 + G + + + E + ++ L++AGADLL ET+ + E A Sbjct: 106 DMSTGGVAIGSSPD------ATYEEAFERYAEQITHLVNAGADLLLAETMISIDETVAAV 159 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAAL 239 E S T+ L G + + L A+GINC + + A + Sbjct: 160 EAAKEICDLPILCSMTVEADGSLYFGGSALEALETLQEV-GASAVGINCSVGPDQLEAVI 218 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 + + +P++ PN+G K + ++ + AGA ++GGCC TT Sbjct: 219 AEMKKIARVPVIAKPNAGMPK-ITEKGEALYSMTPEDFGKHMERLVEAGAGIVGGCCGTT 277 Query: 300 PADIAALKAR 309 P I + +R Sbjct: 278 PEYIREMCSR 287 >UniRef50_Q753B4 AFR410Wp n=1 Tax=Eremothecium gossypii RepID=Q753B4_ASHGO Length = 370 Score = 223 bits (570), Expect = 4e-57, Method: Composition-based stats. Identities = 87/328 (26%), Positives = 140/328 (42%), Gaps = 28/328 (8%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVE----NPELIREVHL 56 M+ + L++ +L++DG M ELE RG ++ LWS + + IR ++ Sbjct: 45 MAAKCAITEFLERN-VLVMDGGMGVELERRGMDVKSPLWSTAPFLRGDRAALDTIRGLYR 103 Query: 57 DYYRAGAQCAITASYQATPAGFAARG---LDEAQSKALIGKSVELARKAREAYLAENPQA 113 ++ AG++ T +YQA+ A + + + + E Sbjct: 104 EFRAAGSRGISTLTYQASFHSMVKYSGSVSSRADYEKFLE-------QVVDFTYRECVDP 156 Query: 114 GTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALL-DAGADLLACETLPN 172 + GSVGPY A+L +G+EY GDY F + P+V D D +A ET+PN Sbjct: 157 ARDYIIGSVGPYAAFLCNGAEYTGDYGFETINFFNYFEPQVSKFATDPRIDAIAFETVPN 216 Query: 173 FSEIEALA--ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGY-----PQVVAL 225 E+ A+ E + S + +D L DGTPL V L+ P ++ Sbjct: 217 VVELMAMLQPEFHALLKNKPFYISISAKDEHVLRDGTPLAVVGQLIRERMDDLPPNLLCF 276 Query: 226 GINCIALENTTAALQHLH-GLTVLPL---VVYPNSGEHYDAVSKTWHHHGE-HCAQLADY 280 G+NC+ L + A L L+ L P+ +YPN +D W + A+ Sbjct: 277 GLNCVDLTRSAAMLAELNMQLQDCPIKFQAIYPNGTSVFDESLSAWRPSKDAESLTWAEA 336 Query: 281 LPQWQAAGARLIGGCCRTTPADIAALKA 308 + + R+IGGCC TTP D+ + Sbjct: 337 VKLYLNQDCRMIGGCCGTTPQDMRQIAE 364 >UniRef50_D2R929 Homocysteine S-methyltransferase n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2R929_9PLAN Length = 293 Score = 223 bits (570), Expect = 4e-57, Method: Composition-based stats. Identities = 84/295 (28%), Positives = 124/295 (42%), Gaps = 25/295 (8%) Query: 20 DGAMATELEARGCNLADSLWSAKVLVENP--ELIREVHLDYYRAGAQCAITASYQATPAG 77 DGA TEL RG + +WSA L + ++R++HLDY +AGA +++ Sbjct: 16 DGATGTELNRRGLDTGLPMWSANALTTDTGLNVLRQIHLDYLQAGADILTANTFRTHRRA 75 Query: 78 FAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYRG 137 A++ ++ L ++V A++A + VAGSV P YR Sbjct: 76 LASK---VHAARELTMRAVATAQEAIAEF------GQAAQVAGSVSPL------EDCYRP 120 Query: 138 DYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSFTL 197 D + +A H R++ L+DAG DLL ET+ + E +A L SF Sbjct: 121 DLVPPDDMCRAEHSERIQHLVDAGVDLLLIETMSSIREA-VIAAKLATITGLPTLVSFVC 179 Query: 198 RDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLT--VLPLVVYPN 255 + G P+ LL V ALG+NC L L + PL+ Y N Sbjct: 180 DGEGRILSGEPVAVAAELLLPL-GVKALGVNCGPAHTLAKPLVELRRICGPDFPLIAYGN 238 Query: 256 SGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKARS 310 G + D + E + W A+++GGCC TTPA I L+ RS Sbjct: 239 IG-YADEAQGWINTDAESPESYLHHAETWP---AQILGGCCGTTPAHIRRLRVRS 289 >UniRef50_C1C2Y0 Homocysteine S-methyltransferase 1 n=1 Tax=Caligus clemensi RepID=C1C2Y0_9MAXI Length = 391 Score = 222 bits (567), Expect = 1e-56, Method: Composition-based stats. Identities = 84/332 (25%), Positives = 141/332 (42%), Gaps = 47/332 (14%) Query: 8 RALLDKQDILLLDGAMATELEARGCN---LADSLWSAKVLVENPELIREVHLDYYRAGA- 63 R L + +I +LDG +T+++ W++++ ENPE ++ H+DY + Sbjct: 11 RVLGSRNEIFILDGGFSTQIQQHAGKDSFEGRPQWTSELNTENPEAVKRSHMDYLSNCSG 70 Query: 64 QCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVG 123 + +YQA + I K+VEL +A +AG + GS+G Sbjct: 71 DLISSNTYQAASSS--------------IEKAVELCDEAILEASHVPRKAG---IVGSLG 113 Query: 124 PYGAYLADGSEYRGDYHCSV-----EAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 PY A+ GSEY S E + +++ R+ L+ AG D++A ET+P E Sbjct: 114 PYAAFQPSGSEYNSSDGMSYPPLADEELKEWYKDRIRHLMIAGVDVIAFETMPCIKEALV 173 Query: 179 LAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVV-----ALGINCIALE 233 +++ A+ W SF RD +HL+ G +D V L +P V +GINC + + Sbjct: 174 ALDIIDNVINAKCWISFQCRDGKHLAYGESFKDAVERLLNHPAFVKRKLLYIGINCTSPK 233 Query: 234 NTTAALQ------------HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHC----AQL 277 ++ L+ +G +P VVYPN G + + + Sbjct: 234 YISSLLKLAERVNKKMNFPDKYGYWRIPYVVYPNRGVYCKEKCCYVLDKDDPLGGGDEGI 293 Query: 278 ADYLPQWQAAGARLIGGCCRTTPADIAALKAR 309 +W G R+IGGCC I ++ + Sbjct: 294 LKRCHEWMLLGTRVIGGCCGVDANLIKEIRNQ 325 >UniRef50_Q2S678 Vitamin B12-dependent methionine synthase family protein n=1 Tax=Salinibacter ruber DSM 13855 RepID=Q2S678_SALRD Length = 320 Score = 222 bits (566), Expect = 1e-56, Method: Composition-based stats. Identities = 90/311 (28%), Positives = 133/311 (42%), Gaps = 35/311 (11%) Query: 16 ILLLDGAMATELEARGCNLADS-LWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 +LLDG + EL RG + LWSA L E P+L++EVH +Y RAGA T +Y Sbjct: 12 PVLLDGGLGQELIRRGMPSTEPSLWSANALTEAPDLVQEVHEEYLRAGADVITTNTYATP 71 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 P + GLD +++AL ++ LA +AR A L+AGS+ P Sbjct: 72 PERLSEAGLD-GRAEALNREAGRLAERARAAV------GRDALIAGSLPPIR------GS 118 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 YR D + +R + L DL CET+ E A A + S Sbjct: 119 YRPDLVGEAGEIEPQYREQA-GYLAPHVDLFLCETMSTPGEARAAARGAAS-TGLPVLVS 176 Query: 195 FTLRDSE-------HLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTV 247 +T+ D L +G L + V L+G P V + +NC E+ +AA+ L LT Sbjct: 177 YTIADPSSPEDAEPRLHNGESLEEAVEALSGLP-VAGVLLNCSHPESISAAVPVLRQLTD 235 Query: 248 LPLVVYPNSGEHY-----------DAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCC 296 + Y N+ H D+ ++ ++ W +AGA ++GGCC Sbjct: 236 RAVGAYANAFTHIPDGFDERADALDSDARPDRREDLAPEAYGRHVEDWLSAGANIVGGCC 295 Query: 297 RTTPADIAALK 307 P IA L+ Sbjct: 296 EVGPGHIAHLR 306 >UniRef50_A9FAG8 Methionine synthase n=91 Tax=Bacteria RepID=A9FAG8_SORC5 Length = 1281 Score = 222 bits (565), Expect = 2e-56, Method: Composition-based stats. Identities = 72/351 (20%), Positives = 130/351 (37%), Gaps = 55/351 (15%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLAD-----------------SLWSAKVLVEN 47 +PL+ LL ++ I+++DGAM T + G AD L+S + Sbjct: 11 HPLQKLL-QRRIVIIDGAMGTTIRTYGMKEADIRGQRFADSKKDLLNNGDLFS----LTQ 65 Query: 48 PELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKA----------------L 91 PE+I ++H + AGA T ++ AT + +D+ + L Sbjct: 66 PEMICDIHRRFLEAGADIIETNTFGATSITQSEFFVDDPREHGGRKDPAFYQGIIDDPFL 125 Query: 92 IGKSVEL----ARKARE-AYLAENPQAGTLLVAGSVGPYGAYL--ADGSEYRGDYHCSVE 144 + E+ AR+ RE A N VAG++GP L + ++ G + + Sbjct: 126 NDLAWEINEQSARQCREWADRVANADGRQRFVAGAIGPLTVSLSNSPDADDPGFRVVTFD 185 Query: 145 AFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRA-----RAWFSFTLRD 199 + + ++ AL+ G+D+L ET+ + +A + S + Sbjct: 186 QVKQAYVHQIRALIAGGSDVLLVETIFDSLNAKAALVAIREVFDKDGKTLPVMISAAVGR 245 Query: 200 SEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLVVYPNSGE 258 + + +A+G+NC + L L + + YPN+G Sbjct: 246 GGETMISAQTVEAFWNAVKHVNPLAIGLNCSLGPDLMYPFLSDLSEKSSAAISCYPNAGL 305 Query: 259 HYDAVSKTWHHHGEHCAQLADYLPQWQAAG-ARLIGGCCRTTPADIAALKA 308 + +A ++ + AG + GGCC TP IAA+ Sbjct: 306 PNPLSPTGF---DLEPPDMARHIGGFADAGLLNIAGGCCGNTPEHIAAIAK 353 >UniRef50_UPI0001BC6543 5-methyltetrahydrofolate--homocysteine methyltransferase n=2 Tax=Fusobacterium RepID=UPI0001BC6543 Length = 290 Score = 221 bits (563), Expect = 3e-56, Method: Composition-based stats. Identities = 75/311 (24%), Positives = 124/311 (39%), Gaps = 41/311 (13%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K+ IL+LDGAM T L + G + LI+++H Y AGA T S+ Sbjct: 7 KRRILVLDGAMGTMLASYGEKP----CYEVLNKTKENLIQKIHEKYIEAGADIITTNSFN 62 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 L E+ L KSVE+A+KA + + GS+GP A L + Sbjct: 63 CNQMALQKYHLKES-VYDLTKKSVEIAKKA------TKNSKKAVYILGSIGPSIANLPE- 114 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA-----YP 187 +++++ + ++ LLD G D L ET+ + ++ + ++ Sbjct: 115 ---------DMKSWKQSYFQQILGLLDGGVDALLLETIYDENKANCILGIIEEVLQAGKR 165 Query: 188 RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLT 246 + S T+ + L GT + V + P +V G+NC +EN + L L T Sbjct: 166 EIPVFCSMTINQNGKLLTGTSITRAVEKM-DRPWIVGFGLNCSYGMENVVSFLPELIWAT 224 Query: 247 VLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQA-AGARLIGGCCRTTPAD--- 302 +VY N+G + E+ ++ + L + ++GGCC T Sbjct: 225 DKYCMVYANAGFP-----NEKGEYTENIEEMLELLQPFLEKHLIHIVGGCCGTNEKYTYA 279 Query: 303 ----IAALKAR 309 IA L R Sbjct: 280 FAKKIALLAER 290 >UniRef50_Q1IQK2 Methionine synthase (B12-dependent) n=40 Tax=cellular organisms RepID=Q1IQK2_ACIBL Length = 407 Score = 221 bits (563), Expect = 3e-56, Method: Composition-based stats. Identities = 68/351 (19%), Positives = 133/351 (37%), Gaps = 53/351 (15%) Query: 4 NNPLRALLDKQDILLLDGAMATELEARGC-----------NLADSLWS--AKVLVENPEL 50 +P+ +L+ I ++DGAM T + G + + L + + P++ Sbjct: 44 QHPIERILED-RIAIIDGAMGTTIRTYGMAEADIRGERFKDSSKGLLNNGDLFSLTQPQM 102 Query: 51 IREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSK--------------------- 89 I ++H + AGA T ++ AT + +D+ + Sbjct: 103 IGDIHRRFLEAGADIIETNTFGATSIVQSEFFVDDPREHGGRKDADFYQKIIDDQFLGDL 162 Query: 90 --ALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYL--ADGSEYRGDYHCSVEA 145 + S + R+ + N + VAG++GP L + ++ G + + Sbjct: 163 AWEINETSAQQCREWADRVA--NATSRPRFVAGALGPLTVSLSNSPDADDPGFRVVTFDQ 220 Query: 146 FQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY-----PRARAWFSFTL-RD 199 + + +V AL+ G D L ET+ + +A + S + R Sbjct: 221 VKIAYIQQVRALIAGGVDFLLVETIFDSLNAKAALVAIREVFDQDGKNIPVMISAAVGRG 280 Query: 200 SEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLVVYPNSGE 258 E + G + + + + +++G+NC + L+ L + + YPN+G Sbjct: 281 GETMISGQTV-EAFWNAVSHVKPLSVGLNCSLGPDLMYPFLEDLSAKADVAISCYPNAGL 339 Query: 259 HYDAVSKTWHHHGEHCAQLADYLPQWQAAG-ARLIGGCCRTTPADIAALKA 308 + ++ T G +A YL ++ AG + GGCC TP IAA+ Sbjct: 340 P-NPLAATGFDFG--PPDMARYLREFAEAGLINIAGGCCGNTPEHIAAIAK 387 >UniRef50_A5ZUF2 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=A5ZUF2_9FIRM Length = 289 Score = 220 bits (562), Expect = 4e-56, Method: Composition-based stats. Identities = 63/309 (20%), Positives = 127/309 (41%), Gaps = 24/309 (7%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M+ R L ++IL+LDGA + L A G + + ++++ ++I+++ Y + Sbjct: 1 MT-KEEFRKL--TENILILDGATGSNLMASGMP--RGICTETWVIDHKDIIQDLQRAYIQ 55 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AG+Q ++ GL + + + V +++ + VAG Sbjct: 56 AGSQVIYAPTFGGNSINLEKHGL-RDKIEEINRTLVGYSKELA---------GSGIYVAG 105 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 + G+++ +Y ++ ++ L DAG DL+A ET+ N E A Sbjct: 106 DITTSGSFITADGDYT------YTEAYNMYQEQIRILADAGIDLIAAETMINIEETLAAV 159 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAAL 239 + + + T+ + G + L A+GINC + + + + Sbjct: 160 DAAASVCDLPIMCTMTVEADGSIFSGGNAVEAAVSLEA-AGADAVGINCSVGPDQLVSVV 218 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 +++ +P++ PN+G K + + + A ++ GA ++GGCC TT Sbjct: 219 RNIKENVSIPVIAKPNAGMPV-IDEKGNAVYSMNAEEFAHHMKVLIENGASVVGGCCGTT 277 Query: 300 PADIAALKA 308 P+ I AL Sbjct: 278 PSFIKALHD 286 >UniRef50_D2PQB9 Methionine synthase n=2 Tax=Actinomycetales RepID=D2PQB9_9ACTO Length = 1199 Score = 220 bits (562), Expect = 4e-56, Method: Composition-based stats. Identities = 87/325 (26%), Positives = 134/325 (41%), Gaps = 34/325 (10%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLAD-------------SLWSAKVLVEN 47 M+ + LR LLD + I +LDGA T L+A D S + + Sbjct: 1 MT-TSSLRDLLD-RRIAVLDGAWGTMLQAANLTSEDYQGDRFLDHSHDVSGDPDLLNLMR 58 Query: 48 PELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYL 107 P+LI +VH Y AGA T ++ AT G A GL + + + + LAR+A + Sbjct: 59 PDLILDVHRQYLDAGADITTTNTFTATSIGQADYGLQ-SLVREMNLEGARLARQAADE-- 115 Query: 108 AENPQAGTLLVAGSVGPYGAY--LADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLL 165 AG VAGSVGP L+ E S E + + ++ AL D G DLL Sbjct: 116 -----AGGRFVAGSVGPLNVTLSLSPRVEDPAYRAVSFEQVRDSYAEQITALRDGGVDLL 170 Query: 166 ACETLPNFSEIE-ALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVA 224 ET+ + + A+A A P W S + S G + + + + + Sbjct: 171 LIETIFDTLNCKAAIAAAREAAPELPLWISLFVDLSGRTLSGQTVEAWWNSIE-HAEPLV 229 Query: 225 LGINCI-ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQ 283 +G+NC + L + +PN+G + + E Q A + + Sbjct: 230 VGVNCSLGARELRPHVADLARFADTYVASHPNAGLP-----NAFGGYDETPEQTAGMIGE 284 Query: 284 WQAAG-ARLIGGCCRTTPADIAALK 307 + +G ++GGCC TTPA IA + Sbjct: 285 FAESGLVNIVGGCCGTTPAHIAKIA 309 >UniRef50_C9M596 Vitamin B12-dependent methionine synthase family protein n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M596_9BACT Length = 808 Score = 220 bits (562), Expect = 4e-56, Method: Composition-based stats. Identities = 68/306 (22%), Positives = 119/306 (38%), Gaps = 28/306 (9%) Query: 4 NNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGA 63 +P R L +D ++ DGAM T L +RG ++ + +PE + VH + AG+ Sbjct: 6 TSPSRRLTLGRDRIIFDGAMGTALGSRGLRRGS--LPEELNLSSPETVAAVHRSFLEAGS 63 Query: 64 QCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVG 123 T ++ A P+ A GL ++ + ++AR+ E + VA +G Sbjct: 64 DFITTNTFGAFPSRLAHAGLS---VGPVVRSACQIARREAERFGG--------FVALDIG 112 Query: 124 PYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALL--DAGADLLACETLPNFSEIEALAE 181 P G + + D ++ E L A D + ET + +EI A A Sbjct: 113 PSGRLMEPLGDATFD---------EIYQGVCEVLHAGAAYCDAVLLETFTDLAEIRAAAL 163 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQ 240 + + + S G + +L+ A G NC ++ Sbjct: 164 AVRENCGLPLLATMSFEPSGRTFSGAS-AEACSLVLSGLGASAFGTNCSAGPRALRETVR 222 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 + G +P++V PN+G + S + G + + ++ G ++GGCC TTP Sbjct: 223 QICGACPVPVIVQPNAGLPEFSGSSVVYSAG--PDEFQSVMGEFARWGVAVLGGCCGTTP 280 Query: 301 ADIAAL 306 I L Sbjct: 281 DYIRRL 286 >UniRef50_C3YH00 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae RepID=C3YH00_BRAFL Length = 1318 Score = 220 bits (561), Expect = 5e-56, Method: Composition-based stats. Identities = 73/320 (22%), Positives = 123/320 (38%), Gaps = 65/320 (20%) Query: 13 KQDILLLDGAMATELE--------ARGCNLADSLW-------SAKVLVENPELIREVHLD 57 ++ I++LDG M T ++ RG D W + + + P ++ ++H Sbjct: 29 RERIMILDGGMGTMIQGYHLEEDGYRGDEFKD--WHKLLKGNNDLLSLTQPNIVYDIHKA 86 Query: 58 YYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLL 117 Y AGA A T ++ T A G++E + L S ELA+KA + A+ Sbjct: 87 YLEAGADFAETNTFSGTRIAQADYGMEELVYR-LNKVSAELAKKAADKVTADTA------ 139 Query: 118 VAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE 177 + + + LLD G D+L ET+ + + + Sbjct: 140 -------------------------WDELVDAYAEQARGLLDGGCDVLMVETIFDTANSK 174 Query: 178 ALAELL-----TAYPRARAWFSFTLRD--SEHLSDGTPLRDVVALLAGYPQVVALGINC- 229 A L Y + S T+ D LS T V+++ P + LG+NC Sbjct: 175 AALFALSQLFEEEYKPVPIFVSGTIVDRSGRTLSGQTSEAFVISVSQAEP--MCLGLNCA 232 Query: 230 IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGA 289 + ++ + T ++ YPN+G + E +A++L + G Sbjct: 233 LGATEMRPFIEAIGKNTTSYVLCYPNAGLPNALGG-----YDETPEIMAEHLRVFAKDGL 287 Query: 290 -RLIGGCCRTTPADIAALKA 308 L+GGCC TTPA I A+ Sbjct: 288 LNLVGGCCGTTPAHIKAIAE 307 >UniRef50_B1HTR8 Methylenetetrahydrofolate reductase n=95 Tax=Bacilli RepID=B1HTR8_LYSSC Length = 647 Score = 220 bits (561), Expect = 5e-56, Method: Composition-based stats. Identities = 73/306 (23%), Positives = 117/306 (38%), Gaps = 27/306 (8%) Query: 3 QNNPLRALLD--KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 + LL+ K +L DGA+ T L G ++ V+ PELI ++H +Y Sbjct: 28 REARFMGLLERLKTHVLTADGAIGTVLYGYGLE----YCHEEMNVQRPELIEKIHREYIA 83 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGA T +Y A A GL E+ + ++ +A++A G V G Sbjct: 84 AGADIIQTNTYGANAIKLARYGL-ESSVQRFNEAAITIAKRAAA--------DGGQFVLG 134 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 ++G + D +VE + LL D L ET +F E+ A Sbjct: 135 TIGGIRGIRKSDATLN-DILKTVE-------EQASVLLAGNPDGLLLETYYDFEELTATL 186 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAAL 239 ++L A ++ + L +G L + L +G+NC + +T A Sbjct: 187 KMLRAKTNIPIIAQVSMHEPGVLQNGMSLNIALHELE-ILGADIVGVNCRLGPYHTIQAF 245 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 + + + YPN+ + + + + G RLIGGCC TT Sbjct: 246 EGVELPEKAFMSAYPNASLLDLEDGRVVYES--EADYFGRAAVELRDQGVRLIGGCCGTT 303 Query: 300 PADIAA 305 P IAA Sbjct: 304 PKHIAA 309 >UniRef50_B7I892 Homocysteine S-methyltransferase family protein n=12 Tax=Proteobacteria RepID=B7I892_ACIB5 Length = 313 Score = 220 bits (561), Expect = 5e-56, Method: Composition-based stats. Identities = 83/302 (27%), Positives = 117/302 (38%), Gaps = 31/302 (10%) Query: 18 LLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPAG 77 +LDG + EL RG WSA L+E PE ++EVHLD+ AGA+ T +Y P Sbjct: 24 ILDGGLGRELARRGAPFRQPEWSALALIEAPETVKEVHLDFINAGAEVITTNNYAVVPFH 83 Query: 78 FAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP-YGAYLADGSEYR 136 E LI ++E A+ A + + +AG + P +G+Y AD Sbjct: 84 IGQERF-ETDGVRLIKVAIEQAKNAVKE------SGKNVKIAGCLPPLFGSYRADL---- 132 Query: 137 GDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSFT 196 E + P + L D ET E+E + LL W SFT Sbjct: 133 ----FQPEQAKNLAEPIINTLA-PEVDFWLAETQSCLKEVETVHALLPQ-DGKDYWVSFT 186 Query: 197 LRDSEH-----LSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL--TVLP 249 L+D L G ++ V + A+ NC E A+ + GL + Sbjct: 187 LQDEIKQEQALLRSGENMQQVADFIKQ-SNAKAVLFNCCQPEVILQAINEIKGLIPESVQ 245 Query: 250 LVVYPNSGEHYDAVSKTWHHHGE-----HCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 + Y N+ D + E + QWQ AGA L+GGCC P IA Sbjct: 246 IGAYANAFPPQDESATANDGLDEIRKDLDAPAYLGFAKQWQQAGASLVGGCCGIGPEHIA 305 Query: 305 AL 306 L Sbjct: 306 EL 307 >UniRef50_C5E3E4 KLTH0H12716p n=1 Tax=Lachancea thermotolerans CBS 6340 RepID=C5E3E4_LACTC Length = 348 Score = 220 bits (560), Expect = 6e-56, Method: Composition-based stats. Identities = 87/329 (26%), Positives = 138/329 (41%), Gaps = 31/329 (9%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLV----ENPELIREVHLDY 58 PL+ K +ILLLDG TELE +G +++ LWS + + E I+E++ D+ Sbjct: 1 MRKPLKEFF-KNNILLLDGGQGTELEKKGVSISHPLWSTLPFIIKNKTHLEAIKEMYRDF 59 Query: 59 YRAGAQCAITASYQATPAGFAAR--GLDEAQSKALIGKSVELARKAREAYLAENPQAGTL 116 AG+ +T +YQA+ + GL ++ + RE + Sbjct: 60 AEAGSNALMTITYQASFSSMKKYSEGLVNSEEDYAAFLDYVIGFTDRECITPDK------ 113 Query: 117 LVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEAL-LDAGADLLACETLPNFSE 175 + GSVGPY L++G+EY G Y F ++ P+V+ L DL+ ET+PN E Sbjct: 114 YLVGSVGPYAGLLSNGAEYSGYYGEGKIDFIDYYSPQVKHFALSPRIDLIGIETIPNIDE 173 Query: 176 IEALA--ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGY-----PQVVALGIN 228 +AL E + S T ++ L DGT L ++ + V IN Sbjct: 174 FKALLSPEFSRLSFSKPYYISVTTDNNGCLRDGTSLNEICRAIKQSASLLPDNFVFFAIN 233 Query: 229 CIALENTTAALQHLHGLTVLPLV--------VYPNSGEHYDAVSKTWH--HHGEHCAQLA 278 C+ + LQ L+ + V YPNSGE Y + +W + Sbjct: 234 CVEFLHCVEILQSLNDCLEMQGVDRRFRFRGAYPNSGEIYHGGTHSWSSNPYAGPEDTWE 293 Query: 279 DYLPQWQAAGARLIGGCCRTTPADIAALK 307 + + ++GGCCRT +I + Sbjct: 294 NLTLGLLSQECLMLGGCCRTGSEEIRQMA 322 >UniRef50_C7LX76 Methylenetetrahydrofolate reductase n=1 Tax=Desulfomicrobium baculatum DSM 4028 RepID=C7LX76_DESBD Length = 599 Score = 218 bits (557), Expect = 1e-55, Method: Composition-based stats. Identities = 70/294 (23%), Positives = 111/294 (37%), Gaps = 25/294 (8%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 + +++ DGAM + L RG + + + + P L++ +H Y AGA+ T ++ A Sbjct: 11 ERVVVADGAMGSLLFDRGVDSSS--CYDALNLTEPALVQSIHKAYADAGAEILETNTFGA 68 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 L ++ + + ELAR VAG++GP G Sbjct: 69 NRVKLGRYDLAHT-TREINLRGAELAR---------GEAGAGRWVAGAMGPLGRM----- 113 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWF 193 G S E + + AL++ G D + ET + S + + A Sbjct: 114 ---GLDAVSQEEMEDVFSQQALALVEGGVDFIMLETFASLSLLLTALRGVKACVSVPVAA 170 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLVV 252 G R+ L +G+NC I +N +Q L +T +PL V Sbjct: 171 QMVFTQRGRTHSGHTARECFDALI-RAGADVVGLNCGIGPKNALEVVQGLGPVT-VPLSV 228 Query: 253 YPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 PN+G + + + A GARL+GGCC T P IAAL Sbjct: 229 LPNAGFPESSGDRLIYAS--SPEYFARRTAACATYGARLLGGCCGTAPEHIAAL 280 >UniRef50_UPI0001BCEC92 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein n=1 Tax=Selenomonas noxia ATCC 43541 RepID=UPI0001BCEC92 Length = 597 Score = 218 bits (555), Expect = 3e-55, Method: Composition-based stats. Identities = 75/309 (24%), Positives = 118/309 (38%), Gaps = 29/309 (9%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M+QN+ K++ L+ DG M T + + +E P ++ +H +Y + Sbjct: 1 MAQNSADIREHIKKEPLVFDGGMGTYYAQKTHTHGKGV--ELANIETPAVVGAIHTEYLQ 58 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGAQ T ++ A + DE+ + +I E+A +A E + A V Sbjct: 59 AGAQAIKTNTFAANRIVYQG---DESLVRRIIRAGWEIAARAAEPFGA--------YVFA 107 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEI-EAL 179 +GP A +R + L GA ET + + E Sbjct: 108 DIGPVTGLPHT-------------DIIAEYRFLADTFLACGATHFLFETNASIEGLIETA 154 Query: 180 AELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAAL 239 A + P A SF+ + DG D++ A + A+G NC+ L Sbjct: 155 AHIKRICPHAFILASFSALPGGYTRDGRFAEDLIHEAAESGSIDAVGFNCVNGVRQMREL 214 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 H G+T LPL + PN+G +T++ L G ++GGCC TT Sbjct: 215 GHHLGMTSLPLSLMPNAGHPIVVDGRTFYESA--PEYFGTSLAAIVRDGISIVGGCCGTT 272 Query: 300 PADIAALKA 308 P I AL A Sbjct: 273 PEHIRALCA 281 >UniRef50_B8M2P0 Homocysteine S-methyltransferase, putative n=1 Tax=Talaromyces stipitatus ATCC 10500 RepID=B8M2P0_TALSN Length = 369 Score = 217 bits (553), Expect = 4e-55, Method: Composition-based stats. Identities = 92/352 (26%), Positives = 150/352 (42%), Gaps = 53/352 (15%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNL----ADSLWSAKVLVENPELIREVHLDYYRAG 62 + L++ ILLLDG + T LEA N+ LWS+ +L+++P ++ H + AG Sbjct: 15 ISKLVNTMQILLLDGGLGTTLEASPFNVQFTPEKPLWSSHLLIDSPSTLQAAHHAFCDAG 74 Query: 63 AQCAITASYQATPAGFAARG--LDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 A +TA+YQ + GF + + ++ L R A + VA Sbjct: 75 ADIILTATYQTSTEGFTRTNSSYTARDAAQYMRSAIPLVRSAV----SSTADDKKRSVAL 130 Query: 121 SVGPYGAYLADGS-EYRGDYHCSVE---AFQAFHRPRVEALLDAG------ADLLACETL 170 S+GPYGA ++ S EY G Y ++ A + +H R++ ++ D +A ETL Sbjct: 131 SLGPYGATMSPVSAEYTGIYPPEMDGENALREWHTQRLKIFTESEDESWDQVDYIAFETL 190 Query: 171 PNFSEIEALAELL-----TAYPRARAWFSFTLRDSEHLSDGTP---LRDVVALLAGYPQV 222 E+ A+ + + W+ + E + + +R V G P+ Sbjct: 191 RRADEVCAVRGAVCDVVGRDSTSKKPWWICGVFPGEQVDEEEIRQWVRAAVGNHPGLPRP 250 Query: 223 VALGINCIALENTTAALQHLHG--------------LTVLP-LVVYPNS--GEHYDAVSK 265 +G+NC ++ A + + + P LV+YP+ GE YD V+K Sbjct: 251 WGIGLNCTRIDRVEAIVSIMRDEVRRLLDQAQIDEWASSKPWLVLYPDGTKGEKYDPVTK 310 Query: 266 TWHHHGEHCAQ------LADYLPQWQAA--GARLIGGCCRTTPADIAALKAR 309 TW + D + A G ++GGCCR PADIAAL+ R Sbjct: 311 TWVQSVTDTVKRPWDEIFWDIIQHQSKAEWGGIVVGGCCRAGPADIAALRRR 362 >UniRef50_B2AAZ0 Predicted CDS Pa_1_5620 n=2 Tax=Sordariales RepID=B2AAZ0_PODAN Length = 371 Score = 217 bits (552), Expect = 6e-55, Method: Composition-based stats. Identities = 94/368 (25%), Positives = 141/368 (38%), Gaps = 73/368 (19%) Query: 4 NNPLRALLDKQDILLLDGAMATELEA-RGCNLAD--SLWSAKVLVENPELIREVHLDYYR 60 P+ + I LDG + T LE G ++ LWS+ +L+ + + + + + + + Sbjct: 6 QTPIMEGRKPRTIKFLDGGLGTTLETIHGVKFSESTPLWSSHLLLTDLQTLADCQMSFAK 65 Query: 61 AGAQCAITASYQATPAGFAA-------RGLDEAQSKALIGKSVELARKAREAYLAENPQA 113 AGA TA+YQA+ GF G+ + +V +AR+A Sbjct: 66 AGADVITTATYQASINGFKNTKTENWPNGVPLPNIGHFLKDAVSIARRAAGKVGGR---- 121 Query: 114 GTLLVAGSVGPYGAYLADGSEYRGDYHCS-----VEAFQAFHRPRVEALLDA-----GAD 163 VA S+GPYGA + +EY G Y V+ +H R + Sbjct: 122 ----VALSLGPYGATMIPSTEYTGHYDIEPSQDIVDKLFHWHSERYNLYVQVPNLLFDVS 177 Query: 164 LLACETLPNFSEIEALAELLTA-------------YPRARAWFSFTLR-DSEHLSDGTPL 209 +A ET+P EI A+ L A Y W S D + + DGT + Sbjct: 178 YIAFETIPRLDEILAIRRFLNADISGGVKLGPREFYHDIPVWISVLFPSDDDKMPDGTSV 237 Query: 210 RDVVALLA----GYPQVVALGINCIALENTTAALQHLHGLTVL-----------PLVVYP 254 D VA + G +GINC + ++ LV+YP Sbjct: 238 EDAVAAMISKEFGSKTPQFVGINCTQVSKLEGLVRQFTKAVEKLVATGAVEKWPGLVLYP 297 Query: 255 NS---GEHYDAVSKTWHHHGEHCA----------QLADYLPQWQAAG---ARLIGGCCRT 298 + GE Y+ +K W GE QLA + + G + LIGGCCRT Sbjct: 298 DGTKVGERYNTATKEWEISGEGSKKTPEDVSWERQLAMVVKEAYDTGGWSSFLIGGCCRT 357 Query: 299 TPADIAAL 306 TP +I L Sbjct: 358 TPENIQRL 365 >UniRef50_C3MDS4 Homocysteine S-methyltransferase, putative n=12 Tax=Bacteria RepID=C3MDS4_RHISN Length = 352 Score = 216 bits (550), Expect = 9e-55, Method: Composition-based stats. Identities = 82/308 (26%), Positives = 130/308 (42%), Gaps = 25/308 (8%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLAD--SLWSAKVLVENPELIREVHLDYYRAG 62 N L LL ++ +LL DGA T L A G + LW+ PE I ++H D+ AG Sbjct: 20 NALSDLLAQKGVLLADGATGTSLFAMGLEAGEAPELWNE----TKPENITKLHQDFVDAG 75 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 A +T S+ T E + AL ++ E+AR + ++ AGSV Sbjct: 76 ADIILTNSFGGTRHRLKLH-QAEDRVHALNKRAAEIARAVADK------APRKVITAGSV 128 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G L S E + ++E L GA++ ET+ + EI A AE Sbjct: 129 GPTGELLIPLG------ALSYEDAVSAFAEQIEGLKAGGAEVAWIETMSSPDEIRAAAEA 182 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQ-VVALGINC-IALENTTAALQ 240 T ++ + + G +D+ + A + VA+G NC + + ++L Sbjct: 183 ATKV-GLPFVYTGSFDTAGKTMMGLHPKDLHTVAAEIGEGPVAVGANCGVGASDILSSLL 241 Query: 241 HLHGLTVLP-LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 + +VV N G + H+ +A+Y AGAR+IGGCC T+ Sbjct: 242 DMTAANPEGTVVVKGNCGIP--EFRGSEIHYSGTPPLMAEYARLAVDAGARIIGGCCGTS 299 Query: 300 PADIAALK 307 +AA++ Sbjct: 300 CNHLAAMR 307 >UniRef50_Q0TQI2 Homocysteine S-methyltransferase family protein n=9 Tax=Clostridium perfringens RepID=Q0TQI2_CLOP1 Length = 279 Score = 215 bits (548), Expect = 2e-54, Method: Composition-based stats. Identities = 71/302 (23%), Positives = 125/302 (41%), Gaps = 25/302 (8%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 ++ L K +++ DGAM T + G NL D+ S + ++ PELI ++H +Y +GA Sbjct: 1 MKNLDLKNGVIIADGAMGTRIMELGVNLKDTP-SELLNIKKPELIEKIHREYIESGANLI 59 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 ++ ++ + + ++G + +A+KA LVA +GP Sbjct: 60 LSNTFMCNIINAKRNNYN---LEEVVGAGIHIAKKAC---------GDGGLVALDIGPLS 107 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 Y+ + S + + R+ DL+ ETL + E E + Sbjct: 108 YYIEEN-------DSSFKEIVYENTERIINASKDKFDLVIFETLGSLKEGEFAVKKAKTL 160 Query: 187 PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLT 246 + SFTL + + + ++++V+ L V ALGINC E AL L Sbjct: 161 TDKKVICSFTLAYKKDIPN--FIKNMVSTLEPL-GVDALGINCTGYEEILIALDILKENI 217 Query: 247 VLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 LP+++ N G + + + + + + G +IGGCC TTP I A+ Sbjct: 218 NLPIMIKANLGIPKKVGEELV--YDKTLEEFKNLSKRALEKGVNIIGGCCGTTPEYIRAI 275 Query: 307 KA 308 Sbjct: 276 CN 277 >UniRef50_C4Z117 Methylenetetrahydrofolate reductase n=1 Tax=Eubacterium eligens ATCC 27750 RepID=C4Z117_EUBE2 Length = 595 Score = 215 bits (547), Expect = 2e-54, Method: Composition-based stats. Identities = 64/299 (21%), Positives = 108/299 (36%), Gaps = 28/299 (9%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K +IL+ DGA T ++ + + +H +Y AGA+ T ++ Sbjct: 15 KSEILVADGAFGTYYAK---KYDTGSLPELANLQASDRVLAIHKEYIEAGAKIIRTNTFA 71 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 + A G DE ++ I +V++AR+A + +LVA +GP Sbjct: 72 SNTVCLGA-GFDEVRNN--IKNAVDIAREAVK--------GTDVLVAADIGPI------- 113 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 G+ E + + V + G D+ ET P I+ E A Sbjct: 114 ---PGENMIEKEHIEKEYVDIVNVFKECGVDIFVFETFPELGFIDKAIE--NAGENGFVI 168 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLV 251 F + + S G R ++ + A G NC + + +Q L Sbjct: 169 TQFAINQFGYSSAGFSARKLIEEAGKNSYIDACGFNCGVGPGHMKKLVQSLINRNDKYFA 228 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKARS 310 V PN+G + + A + + GA +IGGCC TTP I + ++ Sbjct: 229 VLPNAGYPQVVSGRMVFD-DNNAAYFSQIMHDLAEDGADIIGGCCGTTPEYIRQMVLKT 286 >UniRef50_B7AQD9 Methylenetetrahydrofolate reductase n=1 Tax=Bacteroides pectinophilus ATCC 43243 RepID=B7AQD9_9BACE Length = 603 Score = 215 bits (547), Expect = 2e-54, Method: Composition-based stats. Identities = 70/306 (22%), Positives = 118/306 (38%), Gaps = 29/306 (9%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 LR L L+ DGAM T ++ +E P++I +H +Y AGA+ Sbjct: 3 ESLREYLKGHR-LITDGAMGTYYSE--ITNNPEAFAEFANIERPDIIERIHNEYIDAGAK 59 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP 124 T ++ A G+ + K LI + +A++ + G VAG +GP Sbjct: 60 LIRTNTFAANTQML---GIGRDELKKLIEDACRIAQRCAD---------GRAYVAGDIGP 107 Query: 125 YGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 + + +E G +VE ++ + LD D + ET +F +I+ +AE + Sbjct: 108 ----IKENAESEG---SAVEEYKMI----CDIFLDMKVDAIRFETFADFDDIKEVAEYVR 156 Query: 185 AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLH 243 + F L + + G ++ + + G NC I + +Q L Sbjct: 157 SKSDMFIMADFCLNKNGFTAGGISAARIMQQAGQMDCIDSCGFNCGIGSGHMNNIMQKLT 216 Query: 244 GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADI 303 + PN+G Y + + D + + A G +IGGCC T PA I Sbjct: 217 FAKDKYMSCLPNAG--YPEQMNNRMVFMNNASYFCDNMQKISAYGMNIIGGCCGTKPAYI 274 Query: 304 AALKAR 309 L R Sbjct: 275 RELCRR 280 >UniRef50_B8PAR1 Predicted protein (Fragment) n=1 Tax=Postia placenta Mad-698-R RepID=B8PAR1_POSPM Length = 380 Score = 214 bits (545), Expect = 3e-54, Method: Composition-based stats. Identities = 108/380 (28%), Positives = 155/380 (40%), Gaps = 91/380 (23%) Query: 16 ILLLDGAMATELEA-RGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 +L+LDG T LE +++ LWSA+ + +NPELI HL + RAGA +T++YQ Sbjct: 1 VLILDGGFGTTLEDVFHQDISTPLWSARPIEDNPELIIAAHLAFLRAGADVILTSTYQCA 60 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQA------------GTLLVAGSV 122 F G ++ K+V LA +AR Y E + +A S+ Sbjct: 61 FQTFERSGYTREDGVRILRKAVLLATEARRQYKEEGAPDDTSTGLSGTAHVRDIKIALSL 120 Query: 123 GPYGAYLADGSEYRGDYHC-----------------------------SVEAFQAFHRPR 153 GP+GA L+ E+ G Y +V A AFH R Sbjct: 121 GPFGATLSPAQEFDGFYPPPYGPKGLSQEGGNYNAFPDSDDGKAQEEKAVAALTAFHLER 180 Query: 154 VEALLD-----AGADLLACETLPNFSEIEALAELLT-------AYPRARAWFSFTLRDSE 201 + AL++ A D +A ET+P EI A+ + A W S Sbjct: 181 LRALVEDVETWAAIDFVAFETVPLVREIRAIRHAMELLVQENGASAAKPWWISTVYPGGR 240 Query: 202 HLSDGTP------LRDVVALLAG--------YPQVVALGINCIALENTTAALQHL----- 242 + +P +R VV + G P LG+NC + L+ + Sbjct: 241 FPQERSPGEGRLTVRIVVEAIMGEGRLGAPQSPAPWGLGVNCTEPQFIGGLLKEMTNIME 300 Query: 243 -----HGLTVLP-LVVYPNSGEHYDAVSKTWHHHGEHCAQ-LADYLPQWQA----AGAR- 290 G + P LVVYPN G+ YDA S+TW E Q A ++ W AG++ Sbjct: 301 GLGNTAGRSQSPWLVVYPNRGDVYDAASQTWSKGAESIRQNWAVHV--WADVQRVAGSKA 358 Query: 291 ----LIGGCCRTTPADIAAL 306 LIGGCC+T P +IA L Sbjct: 359 WSGCLIGGCCKTGPQEIAEL 378 >UniRef50_A8M0Q1 Homocysteine S-methyltransferase n=3 Tax=Actinomycetales RepID=A8M0Q1_SALAI Length = 307 Score = 213 bits (542), Expect = 8e-54, Method: Composition-based stats. Identities = 82/302 (27%), Positives = 117/302 (38%), Gaps = 23/302 (7%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVEN--PELIREVHLDYYRAGAQCAITASYQ 72 L+LDG + TEL+ RG ++ W+A L + LI ++H +Y AGA +++ Sbjct: 8 RPLILDGGLGTELQRRGRSVTAPWWTAHCLRDADGRRLIAQIHAEYVTAGADVITADTFR 67 Query: 73 ATPAGFAARGL-DEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLAD 131 TP G+ + L+ +V LAR+A + +LVAGSV P Sbjct: 68 TTPRAAHRAGIAGHTVAADLVRTAVALAREAADTV------RRRVLVAGSVAPV------ 115 Query: 132 GSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARA 191 YR D + + H E L DL+ ET+ E A + A A Sbjct: 116 EDCYRPDLVPNDGVLRREHAWLAEQLARTSVDLVLVETMNTAREAVAATRAVCA-EGLPA 174 Query: 192 WFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLV 251 W SF + L GT A + +NC T AL+ L V PL Sbjct: 175 WVSFVCTNDARLLSGTD-VVAAAAAVRAAGADMVLVNCTDPAGTDGALRRLRRPDVGPLG 233 Query: 252 VYPN----SGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 YPN G A + A+ W ++GGCC +TP IA L+ Sbjct: 234 AYPNLEDRRGLPPAAAVDRYLPPRLTPDAFAELCAGWYYL--DVVGGCCGSTPTHIATLR 291 Query: 308 AR 309 R Sbjct: 292 GR 293 >UniRef50_B0PG09 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PG09_9FIRM Length = 406 Score = 213 bits (542), Expect = 9e-54, Method: Composition-based stats. Identities = 71/293 (24%), Positives = 109/293 (37%), Gaps = 31/293 (10%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 LLLDGA TE G L + + E+P+++ V Y AG+ ++ A Sbjct: 12 PLLLDGATGTEYMKAG--LPSGVCVEQWAAEHPDVVARVARGYADAGSDIVYAPTFLANA 69 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 GL E Q L K V ++A +LVAG + G E Sbjct: 70 GNLKNYGLSE-QVIPLNRKIVSTVKQALA--------GRDVLVAGDMSTTGLMCEPFGET 120 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 + + + AL DAGA+LL ET+ SE A + + Sbjct: 121 EFVH------LIGIYAEQASALADAGAELLVIETMSALSECRAAVIAARQ-TGLPVFLTM 173 Query: 196 TLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLVVYP 254 T+ G + + +L + A G+NC ++ + + LPL+ P Sbjct: 174 TVDAEGRTMWGDDVLASMIVLQDM-GISAFGLNCSQGPDDMVPLFERIAPYAKLPLIAKP 232 Query: 255 NSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 N+GE Q D + G ++IGGCC TTP ++AL+ Sbjct: 233 NAGEP-----------PLSPVQFCDKCARLMRRGVKIIGGCCGTTPEYVSALR 274 >UniRef50_Q28RZ7 Homocysteine S-methyltransferase n=13 Tax=Rhodobacteraceae RepID=Q28RZ7_JANSC Length = 297 Score = 211 bits (537), Expect = 3e-53, Method: Composition-based stats. Identities = 95/305 (31%), Positives = 136/305 (44%), Gaps = 30/305 (9%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 +I +LDG M EL +R LWS V+ P L+ EVH D++ AGAQ A +Y Sbjct: 3 EITILDGGMGQELVSRSDVPPTPLWSTDVMRAKPHLVGEVHRDFFNAGAQIATANTYAIH 62 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 EA+ +L +++ AR+AR+A+ G+ LVAG++GP GA Sbjct: 63 RDRLVRAD-AEAEFASLHKTALDQARQARDAH-------GSGLVAGAIGPLGA------S 108 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 YR D A A + + L DLL CET+ + ++ EA+ + + W + Sbjct: 109 YRPDLTPQHSAAVALYAE-IATLHAPLVDLLICETITSLAQAEAVLDACLGH-GVPVWLA 166 Query: 195 FTL--RDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVV 252 F++ RD L G L DV+A+ + AL NC E AAL L G P Sbjct: 167 FSVDDRDGTRLRSGEGLGDVIAMA---GEAAALLANCSVPEVMPAALDIL-GRAGTPFGA 222 Query: 253 YPN------SGEHYDAVSKTW--HHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 Y N +G DA + AD++ W GA ++GGCC PA IA Sbjct: 223 YANGFTEISAGFLDDAPTVDALTSRTDMGPEAYADHVMGWIDQGATIVGGCCEVGPAHIA 282 Query: 305 ALKAR 309 + R Sbjct: 283 EITRR 287 >UniRef50_B7VQ49 Homocysteine S-methyltransferase family protein n=17 Tax=Vibrionales RepID=B7VQ49_VIBSL Length = 301 Score = 211 bits (537), Expect = 3e-53, Method: Composition-based stats. Identities = 81/314 (25%), Positives = 130/314 (41%), Gaps = 36/314 (11%) Query: 11 LDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITAS 70 ++ + + +LDG M EL+ G + LWSA+ L+E P+ + + H ++ AGA+ IT S Sbjct: 1 MNMKTLTILDGGMGRELKEIGAPFSQPLWSAQALIEAPDFVSQAHQNFVDAGAEILITNS 60 Query: 71 YQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLA 130 Y P L E + L S ELA+ + + T+ VAG++ P Sbjct: 61 YACVPFHLGEE-LFEQRGFELAALSGELAKAVADN------ASHTIKVAGAIPP------ 107 Query: 131 DGSEYRGDYHCSVEAFQAFHRPRVEALLDA---GADLLACETLPNFSEIEALAELLTAYP 187 YR D EA P ++ L DA DL ET+ + E E++ +L Sbjct: 108 PFGSYRPDLFKVEEA-----APIIQTLYDAQDPNIDLWIAETICSLQEFESIHAVLKQ-S 161 Query: 188 RARAWFSFTLRDSE----HLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLH 243 +++F+L D++ ++ G + D + LA + NC E A+ Sbjct: 162 NKPCYYAFSLEDTKGDSANIRSGESVTDSIK-LACQSNAKGIMFNCSVPEVMDQAIIDAK 220 Query: 244 GL-----TVLPLVVYPNSGEHYDAVSKTWHHHGE----HCAQLADYLPQWQAAGARLIGG 294 + + L + VY N+ + + E Y +W A GA +IGG Sbjct: 221 KVIGELGSDLEIGVYANNFAPISSEHEANDMLQEIRELDGQGYLVYAKRWHALGANIIGG 280 Query: 295 CCRTTPADIAALKA 308 CC P I AL Sbjct: 281 CCGIGPKHIQALAD 294 >UniRef50_Q2RU64 Methionine synthase (B12-dependent) n=10 Tax=cellular organisms RepID=Q2RU64_RHORT Length = 1182 Score = 210 bits (535), Expect = 5e-53, Method: Composition-based stats. Identities = 69/316 (21%), Positives = 129/316 (40%), Gaps = 29/316 (9%) Query: 7 LRALLD--KQDILLLDGAMATELEARGCNLADSL-----WSAKVLVENPELIREVHLDYY 59 + LD + +LL DG M + ++A ++ + + + P+++R++H Y+ Sbjct: 1 MSRFLDHLRNRVLLCDGGMGSLVQAMDLSVDGDFMGRENCTEVLNLSRPDVVRDIHTRYF 60 Query: 60 RAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVA 119 AGA C T ++ + A L + +++ + ++ E+ V Sbjct: 61 AAGADCVETNTFGGSTLTLAEFDLAD-RTREINRRAAEI----AREAAESFADGRDRFVL 115 Query: 120 GSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEAL 179 GS+GP G++ H + + + E L++ GAD + ET + + +A Sbjct: 116 GSIGP-------GTKLPSLGHIDYDTLKDAITVQCEGLIEGGADAILVETCQDPLQFKAA 168 Query: 180 AEL-----LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALE 233 L T+ + L G + + V +LG+NC + Sbjct: 169 INAAKAARLALGSDTAILLQVTVETTGTLLVGADIAAAATVAHAL-GVDSLGLNCATGPQ 227 Query: 234 NTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW-QAAGARLI 292 + ++ L + + PN+G KT H+ A+LAD+ ++ + G LI Sbjct: 228 EMSEHVRWLKENWPGLISLQPNAGLPELLDGKT--HYPLTPAELADWHGRFIREDGVNLI 285 Query: 293 GGCCRTTPADIAALKA 308 GGCC TTP IAA+ A Sbjct: 286 GGCCGTTPDHIAAVNA 301 >UniRef50_C8VHP4 Homocysteine S-methyltransferase (Eurofung) n=5 Tax=Eurotiomycetidae RepID=C8VHP4_EMENI Length = 355 Score = 210 bits (535), Expect = 6e-53, Method: Composition-based stats. Identities = 95/351 (27%), Positives = 146/351 (41%), Gaps = 59/351 (16%) Query: 15 DILLLDGAMATELEARGCNL----ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITAS 70 ILLLDG + T LE+ N+ LWS+ +L+ +P ++ H +Y AGA +TA+ Sbjct: 2 KILLLDGGLGTTLESYPFNITFTSETPLWSSHLLISSPSTLQSAHRAFYDAGADILLTAT 61 Query: 71 YQATPAGFAARGLDEA--QSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 YQ++ GFA + + ++ L R A + + PQ VA S+GPYGA Sbjct: 62 YQSSIEGFARTDASHTINDAGDYMRSAIPLVRGAIPSSARQRPQQCR--VALSLGPYGAT 119 Query: 129 LAD-GSEYRGDYHCSV---EAFQAFHRPRVEALLD-----AGADLLACETLPNFSEIEAL 179 ++ +EY G Y + +A + +H R+ +D D +A ETL E+ A+ Sbjct: 120 MSPVAAEYTGAYPPEMDGEDALRQWHAGRLNVFVDDRESWDQVDFVAFETLIRADEVCAV 179 Query: 180 AELLTAYP--------RARAWFS--FTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC 229 + R W F + + + V G P+ +G+NC Sbjct: 180 RGAMKDVCVGPEIHRRRKPWWICGVFPAEEVDRTQVRQWVDAAVGQRPGLPRPWGIGLNC 239 Query: 230 IALENTTAALQHLH--------------------GLTVLP-LVVYPNS--GEHYDAVSKT 266 +EN + + + P LV+YP+ GE YD V+KT Sbjct: 240 TRIENVAKIVAIMRDELHCLLSRGKEDGFVDEWDAASGKPWLVLYPDGTKGEKYDPVTKT 299 Query: 267 WHHHG-----EHCAQLADYLPQWQA---AGARLIGGCCRTTPADIAALKAR 309 W L D + G ++GGCCR PADIAAL+ R Sbjct: 300 WVARETVVRCPWDESLWDVVQGQSEGDWEGI-IVGGCCRAGPADIAALRRR 349 >UniRef50_A7VPD0 Methylenetetrahydrofolate reductase n=1 Tax=Clostridium leptum DSM 753 RepID=A7VPD0_9CLOT Length = 600 Score = 210 bits (534), Expect = 6e-53, Method: Composition-based stats. Identities = 71/308 (23%), Positives = 119/308 (38%), Gaps = 36/308 (11%) Query: 7 LRALLDKQDILLLDGAMATEL-EARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQC 65 L LL ++ ++ DGAM T + G ++ + W + PELI E+H +Y +AGAQ Sbjct: 3 LDTLLKQKRPVITDGAMGTYFTQKTGFSIHECEW---ANISRPELISEIHREYVKAGAQF 59 Query: 66 AITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY 125 T ++ A G A ++ LA++A + Sbjct: 60 LRTNTFSANTKSL---GRPLADVLEIVRAGYRLAKEAAGCQAVAAADMTAIY-------- 108 Query: 126 GAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL-T 184 RGD + +A L GA++ ETL S + +A+ L Sbjct: 109 ---------PRGDEETD---LLPEYLAIADAFLSEGAEVFLFETLTELSPFDQIADYLKK 156 Query: 185 AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQV-VALGINC-IALENTTAALQHL 242 P + SFT+ G PLR ++ + + ++ +G+NC + + L Sbjct: 157 KKPECKVLISFTVSPEGITRLGVPLRRLLDEVKPHRELFDGIGLNCGCGPAHILKFAREL 216 Query: 243 HGLT----VLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRT 298 + LP++V PN+G Y A+ + + + G +IGGCC T Sbjct: 217 LSYSRQYLSLPVLVMPNAG--YPAMEENRTVFDTSPEYFSHQAVRIAELGVDMIGGCCGT 274 Query: 299 TPADIAAL 306 TP + L Sbjct: 275 TPKHLQLL 282 >UniRef50_Q0SIE4 Methionine synthase n=23 Tax=Bacteria RepID=Q0SIE4_RHOSR Length = 1189 Score = 210 bits (534), Expect = 8e-53, Method: Composition-based stats. Identities = 65/315 (20%), Positives = 121/315 (38%), Gaps = 27/315 (8%) Query: 8 RALLD--KQDILLLDGAMATELEARGCNLADSL----WSAKVLVENPELIREVHLDYYRA 61 ALLD Q +++ DGAM T L+A L D L + + P++++++H Y+ A Sbjct: 7 SALLDALNQRVVIGDGAMGTMLQAADLTLDDFLGLEGCNEILNDTRPDVLKDIHRAYFEA 66 Query: 62 GAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGS 121 GA T ++ A + + + + L K LAR + + V GS Sbjct: 67 GADAVETNTFGCNLPNLADYDISD-RIRELAEKGTRLARDVADE-MGPGRDGMGRFVLGS 124 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA- 180 +GP G++ H + + ++D GAD + ET + +++A Sbjct: 125 MGP-------GTKLPTLGHAPFAILRDAYAEAAMGMIDGGADAILVETCQDLLQVKAAIL 177 Query: 181 ----ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENT 235 + T R T+ + + G+ + + L + +G+NC Sbjct: 178 GSQRAMETLGSRLPIITHVTVETTGTMLLGSEIGAALTALEPL-GIDMIGLNCATGPAEM 236 Query: 236 TAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHH--HGEHCAQLADYLPQWQAAGARLIG 293 + L+HL + LP+ V PN+G + + E L+ ++ ++ Sbjct: 237 SEHLRHLSKYSSLPVSVMPNAGLPQLGPNGAEYPLTAEELAEALSGFVTEFGLGLVGGCC 296 Query: 294 GCCRTTPADIAALKA 308 TTP I + Sbjct: 297 ---GTTPEHIRQVAE 308 >UniRef50_A1WU24 Homocysteine S-methyltransferase n=7 Tax=Proteobacteria RepID=A1WU24_HALHL Length = 305 Score = 209 bits (533), Expect = 9e-53, Method: Composition-based stats. Identities = 85/309 (27%), Positives = 123/309 (39%), Gaps = 24/309 (7%) Query: 10 LLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITA 69 + ++D++LLDG M EL R LWSA+V+++ P+L+ H D+ +AGA+ Sbjct: 1 MTQERDVVLLDGGMGQELRRRSSQPVTPLWSAQVMLDEPDLVTAAHRDFIQAGARVITAN 60 Query: 70 SYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYL 129 +Y ATP A G E + S+ A + + +AG + P A Sbjct: 61 TYSATPQRLARDGAPE------LFDSLHAAALDAARQARDASGQQDVRIAGCLPPLVA-- 112 Query: 130 ADGSEYRGDYHCSVEAFQAFHRPRVEALLDA-GADLLACETLPNFSEIEALAELLTAYPR 188 YR D + +R VEA A G DL CET+ + + A Sbjct: 113 ----SYRPDVAPNDADCLEGYRRMVEAQAQAQGVDLFICETM-SLAREARAATEAAVESN 167 Query: 189 ARAWFSFTLRDSE--HLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLT 246 W +FT+ D + L G L + L +NC E T A+ L GL Sbjct: 168 LPVWVAFTVDDGDGTRLRSGESLIQAAQAVVAAGAERVL-VNCAIPEAVTTAMGELTGL- 225 Query: 247 VLPLVVYPNSG------EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 +P Y N+ + V A A++ W GA L+GGCC P Sbjct: 226 GVPFGGYANAFTSVAALQPGGTVDVLESRTDLDPAAYAEHALHWVEQGATLVGGCCEVGP 285 Query: 301 ADIAALKAR 309 A IA L R Sbjct: 286 AHIAELAER 294 >UniRef50_B1A1E6 Homocysteine methyltransferase (Fragment) n=1 Tax=Flammeovirga yaeyamensis RepID=B1A1E6_9SPHI Length = 242 Score = 209 bits (532), Expect = 1e-52, Method: Composition-based stats. Identities = 80/222 (36%), Positives = 128/222 (57%), Gaps = 5/222 (2%) Query: 47 NPELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAY 106 E+I+ HL+Y ++GA+ I++SYQA+ GF +G + L+ K+ E+A+ A+E Y Sbjct: 2 QEEVIKNAHLNYLKSGAEIIISSSYQASIKGFMEKGFSHEVAIDLLKKTTEIAQSAKEEY 61 Query: 107 LAENPQAGTLLVAGSVGPYGAYLADGSEYRG-DYHCSVEAFQAFHRPRVEALLDAGADLL 165 + +AGS+GPY AYLADGSEY+G D ++FH R+ + D+L Sbjct: 62 RE--ISKREVFIAGSIGPYAAYLADGSEYKGYDEAVDENTLRSFHNERLRIIDATDIDVL 119 Query: 166 ACETLPNFSEIEALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVAL 225 A ET+P+ E + L +L+ +AWFSF+ ++ + L+DGT + D+V+LL V+AL Sbjct: 120 AVETIPSLEEAKVLNDLIEKCGH-KAWFSFSCKNEKQLNDGTDIIDIVSLLKHNNNVMAL 178 Query: 226 GINCIALENTTAALQH-LHGLTVLPLVVYPNSGEHYDAVSKT 266 GINC + + L+ +V+YPN+G Y+ +KT Sbjct: 179 GINCTHPKYILGLISEILNAGWKKKIVIYPNAGMVYNPDTKT 220 >UniRef50_B5JEM8 Homocysteine S-methyltransferase, putative n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JEM8_9BACT Length = 318 Score = 208 bits (531), Expect = 2e-52, Method: Composition-based stats. Identities = 61/305 (20%), Positives = 108/305 (35%), Gaps = 28/305 (9%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 ++ +L+ DGAM T+L A G S + +P+ + + Y +G+ C IT ++ Sbjct: 27 REKVLVSDGAMGTQLMAAGLEAGGS--GEMWNLTHPDRVLAIQKRYVDSGSNCIITNTFG 84 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 G + Q + +V++AR A VGP G + Sbjct: 85 GNGLMLRRHGHFD-QLAEINQAAVKIARDAFGGGEGFVFG--------DVGPVGGVMEPY 135 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 + + R +++AL++AGAD + ET + +EI E Y Sbjct: 136 GDLKPA------DVAEGVRIQIQALVEAGADAIIIETQTDLNEIALGIEAAKKYGAPCII 189 Query: 193 FSFTLRDSE-----HLSDGTPLRDVVALLAGYPQVVALGINCIALENTT---AALQHLHG 244 S S G L V L +NC + T ++ Sbjct: 190 ASLAYDKSHDGSFFRTMMGISPEKAAEELTDL-GVDILALNCGTGIDMTVAREIIEEYKD 248 Query: 245 LTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 + + PN+G K + + ++ L G ++GGCC + P I Sbjct: 249 NSDAFTMAQPNAGLPVLENMKAVYK--QTPTEMVSTLDALLEEGVNIVGGCCGSNPDHIR 306 Query: 305 ALKAR 309 A++ + Sbjct: 307 AIREK 311 >UniRef50_A4J5C2 Methylenetetrahydrofolate reductase n=5 Tax=Clostridiales RepID=A4J5C2_DESRM Length = 598 Score = 207 bits (526), Expect = 5e-52, Method: Composition-based stats. Identities = 59/304 (19%), Positives = 120/304 (39%), Gaps = 26/304 (8%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 +R L K +IL+ DGAM T ++ + PE+I +H +Y AGA+ Sbjct: 2 IREYL-KNNILITDGAMGTYYAQITGKYN--VFPEFANINEPEIIERIHTEYINAGAKLI 58 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 T ++ A + +++ K ++ ++LA K Q ++ +A S+GP Sbjct: 59 KTNTFSANSRVLK---IPKSEVKKIVLAGLDLANKVA--------QGKSIFIAASIGPI- 106 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 E E ++ V+ L++ + ET + S++ + + + Sbjct: 107 ------PEMFDKMETDQENSLDEYKFIVDIFLNSDIKIFMFETFSDVSDLLEITKYIKVK 160 Query: 187 PRARAWFS-FTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHG 244 + + F G + ++A + + A G NC + + +L+ L+ Sbjct: 161 DSSAFIVTQFATTPEGFTRKGLSNKHIIAEVKKSKSIDAYGFNCGVGPTHLFNSLKKLNF 220 Query: 245 LTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 + + PN+G Y + + ++ A+ + G +++GGCC TTP I Sbjct: 221 ADDM-VAAAPNAG--YPEIVHERMVYIQNPNYFAEKMKDISGLGVKILGGCCGTTPIHIE 277 Query: 305 ALKA 308 + Sbjct: 278 KMSE 281 >UniRef50_A5N923 Methylenetetrahydrofolate reductase n=2 Tax=Clostridium kluyveri RepID=A5N923_CLOK5 Length = 590 Score = 206 bits (524), Expect = 9e-52, Method: Composition-based stats. Identities = 59/295 (20%), Positives = 110/295 (37%), Gaps = 31/295 (10%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K+ L+ DGAM T + + + I ++H +Y AG T ++ Sbjct: 4 KEKPLIFDGAMGTYYPRISKDPLPKC--ELANIYDRNTILKIHREYIEAGCMAIKTNTFG 61 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A + D + K +I E+A++A + +LV +GP +L Sbjct: 62 ANKVSLES---DFNKVKEVIINGYEIAKEAAK--------DTEVLVFADIGPIP-FLESM 109 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY-PRARA 191 Y G ++ V+ L+ GA ET + + ++E + P A Sbjct: 110 DLYEG------------YKEIVDLFLELGAKYFIFETFSSDEYLREISEYIKGKDPEAYI 157 Query: 192 WFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPL 250 F + + G + ++ + P + A G NC + ++ + + + Sbjct: 158 LMEFAVSPEGYTRVGKSGKKLIENILKIPTIDACGFNCFSGPYHLLQYIKTFN-IGNETI 216 Query: 251 VVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAA 305 V PNSG ++T+ + + A + + G ++GGCC TTP I Sbjct: 217 SVMPNSGYPTVIDNRTFFDNTK--EYFAQRMLEIAKQGVSILGGCCGTTPEFIRE 269 >UniRef50_B4DBI1 Homocysteine S-methyltransferase n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4DBI1_9BACT Length = 283 Score = 205 bits (522), Expect = 2e-51, Method: Composition-based stats. Identities = 72/296 (24%), Positives = 112/296 (37%), Gaps = 29/296 (9%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 + +L+ DGAM TEL A G L ++ V +P+L+R VH Y AGA+ T ++ Sbjct: 8 QHRVLIGDGAMGTELLAHGVPPGRCL--EELCVSDPDLVRGVHERYIAAGARLIETNTFG 65 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A A G E + L + +LA+ + + VAG VGP G + Sbjct: 66 ANAVRLAQYGC-EHRVGELNWTAAQLAKDVA--------RGKDVYVAGCVGPLGITAEEA 116 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 + D H ++ ALLD G ++ ET + E+ E A Sbjct: 117 AARGIDRH-------EVFTDQIGALLDGGCRIIFLETFLDADELLVALEAKQALHHCPVV 169 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVV 252 T D + + +A + + +G NC+ + L + L Sbjct: 170 AMLTSNDRQA------FQAAIAKVRA-AEAEVVGANCVDGTHALHLLDGMDPDAT--LAA 220 Query: 253 YPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 +P++G + + A G RL+GGCC P IAAL A Sbjct: 221 FPSAGLPKTHDQQL--AYPTTPEVFAANARTLAERGVRLLGGCCGVGPQHIAALAA 274 >UniRef50_C4GEB4 Methylenetetrahydrofolate reductase n=1 Tax=Shuttleworthia satelles DSM 14600 RepID=C4GEB4_9FIRM Length = 670 Score = 205 bits (521), Expect = 2e-51, Method: Composition-based stats. Identities = 83/325 (25%), Positives = 123/325 (37%), Gaps = 38/325 (11%) Query: 7 LRALLDKQDILLLDGAMATELEAR-GCNLADSLWSAKVLVENPELIREVHLDYYRAGAQC 65 +R L K+ LL DGA T + +S + V V P+ ++ +H Y AGA Sbjct: 3 IREYL-KEHTLLFDGAFGTYYTKQFRPEKEESFFPEYVNVSRPDRVKAIHRKYLSAGAHA 61 Query: 66 AITASYQATPAGFAA----------RGLDEAQSKALIGKS----------VELARKAREA 105 T ++ A P G A+ L S E AR+A + Sbjct: 62 IKTNTFGAYPGILMKDAGETKKLITAGFSLAEEALLNHLSKDVKNRPETTGEFARRAGQE 121 Query: 106 YLAENPQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLL 165 AE + +GP A G E + ++ +++ L+ GA Sbjct: 122 RSAEASGEEDYFIFADLGP-----APGEE--------EKERILAYQMAIDSFLETGARYF 168 Query: 166 ACETLPNFSE-IEALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVA 224 ETLP +EA+ L P A SF + S+G RD++A AG V A Sbjct: 169 LFETLPEEKTVLEAIRYLKDQCPGAYTISSFAVMPDGFSSEGCNYRDMLAAAAGESAVDA 228 Query: 225 LGINCIALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW 284 +G+NC++ L PL++ PN+G Y V + A L + Sbjct: 229 VGLNCMSSVWHMDHLIRQIPDPGKPLLLMPNAG--YPVVRGYRTVFEGNADYFARILARD 286 Query: 285 QAAGARLIGGCCRTTPADIAALKAR 309 G ++GGCC TTP I L R Sbjct: 287 AGQGVAMVGGCCGTTPDHIRLLADR 311 >UniRef50_A9GUQ7 Putative homocysteine S-methyltransferase family protein n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9GUQ7_SORC5 Length = 309 Score = 203 bits (516), Expect = 7e-51, Method: Composition-based stats. Identities = 90/297 (30%), Positives = 124/297 (41%), Gaps = 27/297 (9%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENP--ELIREVHLDYYRAGAQCAITASYQA 73 I++LDG + TEL ARG LWSA L++ +++R +H DY RAGA +++ Sbjct: 20 IVVLDGPLGTELAARGVETPAPLWSAAALLDARGRDVVRAIHRDYARAGATVHTANTFRT 79 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 R A L ++V LAR+A + VAGS+ P Sbjct: 80 ------RRRQAGAAWAELASRAVSLAREAV------RGEGPRHRVAGSIAPL------ED 121 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWF 193 YR D + + HR AL AG DLL CET P+ E E A AW Sbjct: 122 CYRPDLSPA--DARQEHRELARALASAGVDLLLCETFPHVGEALVALEEAVA-TGVEAWV 178 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVY 253 SFT L + A L +NC T A ++ L +P Y Sbjct: 179 SFTAGPGSDLLSPEDVGRAAREAAARGASAVL-VNCTPATRTLAHIERLAA-CGVPFGAY 236 Query: 254 PNSGEHYDAVS--KTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 N+G + + G A+ A+ +W AGA ++GGCC T P IAAL+A Sbjct: 237 ANAGAEAEGLGWGVGVDQRGSAAARYAELARRWLEAGATIVGGCCGTGPGHIAALRA 293 >UniRef50_A6S563 Putative uncharacterized protein n=2 Tax=Sclerotiniaceae RepID=A6S563_BOTFB Length = 369 Score = 203 bits (516), Expect = 9e-51, Method: Composition-based stats. Identities = 86/362 (23%), Positives = 142/362 (39%), Gaps = 72/362 (19%) Query: 15 DILLLDGAMATEL---EARGCNLADSLWSAKVLV-ENPE---LIREVHLDYYRAGAQCAI 67 I LLDG + T L + LWS+++L+ +P + + AGA + Sbjct: 6 KIHLLDGGLGTTLGDSHQVQFTEKEPLWSSQLLIPTHPHGPKTLLATQKSFVDAGADILL 65 Query: 68 TASYQATPAGFAARGL---------------DEAQSKALIGKSVELARKAREAYLAENPQ 112 TA+YQ + GF G D+ + ++ +V++A A N + Sbjct: 66 TATYQTSYEGFGGSGYAVHSHSSSNSGKADGDKEEVNGIMRSAVDIASDAFSTKKDSNGK 125 Query: 113 AGTLLVAGSVGPYGAYLADGSEYRGDY---HCSVEAFQAFHRPRVEALLD-----AGADL 164 +A S+G YGA + G EY G Y H S E ++H R+ D Sbjct: 126 -----IALSLGAYGAIMTPGQEYTGKYDDDHKSSEQLSSWHHERISVFSRDPKCWERVDY 180 Query: 165 LACETLPNFSEIEALAELLTAYPR--------ARAWFSFTLRDSEH-LSDGTPLRDVVAL 215 +A ET+P EIE + + + W + + L G+ ++ ++ Sbjct: 181 VAFETIPLLEEIEGVRKSMGEVENSNGGTAGSKPFWITCVFPGEGNCLPGGSSVQQIMQA 240 Query: 216 L----AGYPQVVALGINCIAL----------ENTTAALQHLHGLTVLP-LVVYPNS---G 257 + G P +G+NC + E AL ++ P LVVYP+ G Sbjct: 241 MLGNKGGSPVPFGIGLNCTKVGKVESLILEFEQEVKALIEKGDVSEWPSLVVYPDGTIKG 300 Query: 258 EHYDAVSKTW---HHHGEHCAQLADYLPQWQ----AAGA---RLIGGCCRTTPADIAALK 307 E Y+ +K W G+ Q + + + G ++GGCC+TTP +I L+ Sbjct: 301 EVYNTSTKVWEIREPPGKEDLQWDEAVLEIVRRARDRGLWEDIIVGGCCKTTPREIGKLR 360 Query: 308 AR 309 R Sbjct: 361 ER 362 >UniRef50_A8SCX4 Methylenetetrahydrofolate reductase n=3 Tax=Clostridiales RepID=A8SCX4_9FIRM Length = 605 Score = 202 bits (515), Expect = 1e-50, Method: Composition-based stats. Identities = 78/298 (26%), Positives = 113/298 (37%), Gaps = 33/298 (11%) Query: 11 LDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITAS 70 L Q LL DG M T + + +PE I VH Y AGA T + Sbjct: 18 LLAQRPLLFDGGMGTY-----YKAKPGQECEQANLTDPEGILAVHRAYLAAGADAIKTNT 72 Query: 71 YQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLA 130 + + AA + + L +LA KA A V +GP A Sbjct: 73 F--SLPRLAAA--QQPGWEQLADAGWQLAVKAAGETGAA--------VFADLGP-----A 115 Query: 131 DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE-IEALAELLTAYPRA 189 +E + + + GA ETL +EA+ L P A Sbjct: 116 PDTENLPA--------EQVYLAVAKRFALLGARNFLFETLSAEDGVLEAIRALKQTVPEA 167 Query: 190 RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLP 249 SF + + +G ++V +A V A+G+NC++ AL G LP Sbjct: 168 FVLVSFAVLPDGYTREGRYCAELVRRVAQSGVVDAVGLNCVSAPGAMRALVQQLGDAGLP 227 Query: 250 LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 L V PN+G Y V++ + A L + + G R++GGCC TTP IAAL+ Sbjct: 228 LSVMPNAG--YPVVARAQVRYQGKPEYFARELSRLASEGVRILGGCCGTTPQHIAALR 283 >UniRef50_B9NLU8 Homocysteine S-methyltransferase family protein n=4 Tax=Rhodobacteraceae RepID=B9NLU8_9RHOB Length = 309 Score = 202 bits (514), Expect = 2e-50, Method: Composition-based stats. Identities = 86/304 (28%), Positives = 127/304 (41%), Gaps = 29/304 (9%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 DI LLDG++ EL R + LWS +V+++ P+L+ +VH DY+R GA A T +Y Sbjct: 3 DITLLDGSIGQELVKRSGDQPTPLWSTQVMMDRPDLVGDVHADYFRRGATVATTNTYALH 62 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 + G+ E + +L+ ++ A +A + +AG++GP + Sbjct: 63 RSRLRRIGM-EDKLASLVDAALSQAERACVGSEGQ--------IAGALGPV------LAS 107 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 YR D + A V+ + D DL ET+ + E E TA W + Sbjct: 108 YRPDLKPDPDEAAARFSELVQLMADR-VDLFLIETVSSVLEGEGALR-GTANCGKPVWLA 165 Query: 195 FTL--RDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVV 252 ++ D L G L D+ L+A + V A+ INC E AAL + L P Sbjct: 166 VSVNDEDGTRLRSGERLADIQPLIARF-DVAAVLINCSKPEAIPAAL-DVIALMGRPFGA 223 Query: 253 YPNSGEHY--------DAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 Y N H V H A A + QW A GA ++GGCC P I Sbjct: 224 YANGFSHIADAFLTEAPTVDVLEQRHDLGPAAYAAHAMQWVAQGATIVGGCCEVGPDHIE 283 Query: 305 ALKA 308 L Sbjct: 284 TLAR 287 >UniRef50_D2S8U0 Homocysteine S-methyltransferase n=12 Tax=Actinomycetales RepID=D2S8U0_9ACTO Length = 314 Score = 201 bits (512), Expect = 2e-50, Method: Composition-based stats. Identities = 116/294 (39%), Positives = 155/294 (52%), Gaps = 21/294 (7%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 ++LDG +AT+LEA+G +L+ LWS+++L + PE + H + AGAQ A TASYQ + Sbjct: 14 PVVLDGGLATQLEAQGHDLSSELWSSRLLHDAPEAVVAAHAAFAAAGAQVATTASYQVSV 73 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 G AA GLD +++ L+ +SV LA + +AGSVGPYGA LADGSEY Sbjct: 74 EGLAAAGLDATEARRLVVRSVHLAERGA----------PDAWIAGSVGPYGAALADGSEY 123 Query: 136 RGDY--HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWF 193 G Y V+ + +HRPR+E L +AGAD+LACET+P + W Sbjct: 124 TGAYADEIGVDRLRQWHRPRMEWLAEAGADVLACETVPAAA-EAEALLEEADMLGMPVWL 182 Query: 194 SFT--LRDSE--HLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLP 249 S T L G P +V A+ VVA+G+NC + AA G+ P Sbjct: 183 SLTTVLDSDGVVRTRRGEPAGEVFAMARDLDAVVAVGVNCTDPDGVLAA-VTAAGVAGRP 241 Query: 250 LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADI 303 +VVYPNSGE +DA + W A W AGARL+GGCCR P I Sbjct: 242 VVVYPNSGERWDAAGRRWTGTAGLSPHNA---LTWVHAGARLVGGCCRVGPRSI 292 >UniRef50_C0ADK0 Homocysteine S-methyltransferase n=1 Tax=Opitutaceae bacterium TAV2 RepID=C0ADK0_9BACT Length = 306 Score = 201 bits (512), Expect = 3e-50, Method: Composition-based stats. Identities = 75/301 (24%), Positives = 112/301 (37%), Gaps = 30/301 (9%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 L DGA T+L+ G +S + ++E P+ ++ VH Y AGA T ++ T Sbjct: 16 RPLQCDGATGTQLQQLGLRPGESC--ERWVIEQPDRVKLVHQRYLDAGADLLTTNTFGGT 73 Query: 75 PAGFAARGL-DEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 AA G DEA++ + + LAR+ V G +GP+G L Sbjct: 74 TLALAAHGFTDEARAAEINRAAARLAREVA---------GERAWVLGDMGPFGGILEPYG 124 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWF 193 E + QA ALL+ GAD + ET+ + E Sbjct: 125 ETESAVAAAAFRAQA------AALLEGGADAILVETMSDPVEAALAVAAAREAGAQVVIA 178 Query: 194 SFTLR-----DSEHLSDGTPLRDVVALLAGYPQVVALGINCIAL----ENTTAALQHLHG 244 +FT + GT + V + +G NC + A Q + Sbjct: 179 TFTFQHMAAVADFRTMMGTDVPAAVRAVLD-AGAQVVGANCGTELSLDDYALLAGQLVAA 237 Query: 245 LTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 P++V PN+G + A A + G R++GGCC TTPA IA Sbjct: 238 AQGRPVIVQPNAGSPVRDGDAI--SYRTTPADFAGAAACYLKLGVRIVGGCCGTTPAHIA 295 Query: 305 A 305 A Sbjct: 296 A 296 >UniRef50_UPI000190A21A homocysteine S-methyltransferase n=2 Tax=Rhizobium etli RepID=UPI000190A21A Length = 303 Score = 201 bits (511), Expect = 3e-50, Method: Composition-based stats. Identities = 85/310 (27%), Positives = 124/310 (40%), Gaps = 35/310 (11%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 I +LDG M+ EL G L WSA L+ +P+++REVH ++ AG++ + SY P Sbjct: 4 IRILDGGMSRELLRLGAELKQPEWSALALINSPDIVREVHKEFIEAGSEIIFSNSYALVP 63 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 + ALI + LAR+A ++ +LVAGS+ P Y Sbjct: 64 FHIGEDRF-RKEGAALIRLAGRLAREAADSVT-----DRKVLVAGSLPPI------FGSY 111 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 + E Q + + VE L D+ ETL +E EA+ E + A W SF Sbjct: 112 EPQ-NFRPERVQDYLKVLVENLA-PFVDIWLGETLSLIAEGEAVREAVAA-SGKPFWISF 168 Query: 196 TLRDSE--------HLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL-- 245 TL D E L G + + A A A NC E AA++ + Sbjct: 169 TLADDEADIKSGEPKLRSGESV-EAAASWAVSSGAEAFLFNCSKPEVMRAAVETAARVFR 227 Query: 246 -TVLPL-------VVYPNSGEHYDAVSKTWHHHGE-HCAQLADYLPQWQAAGARLIGGCC 296 T P+ + +G H G+ + + + W AGA +IGGCC Sbjct: 228 KTDAPIENRRLCQCLRRGTGAHRPPNEGLHETRGDLNDDVYSRFACSWAEAGATIIGGCC 287 Query: 297 RTTPADIAAL 306 A I L Sbjct: 288 GIGAAHIHRL 297 >UniRef50_B7G9Z1 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B7G9Z1_PHATR Length = 418 Score = 201 bits (511), Expect = 4e-50, Method: Composition-based stats. Identities = 111/372 (29%), Positives = 160/372 (43%), Gaps = 79/372 (21%) Query: 15 DILLLDGAMATELEA-RGCNLADSLWSAKVLVEN---PE----------------LIREV 54 IL+LDG ++T LE+ ADS S K+ P L+R+ Sbjct: 32 RILVLDGGVSTHLESNLSSTNADSASSDKLSCRTCAFPHRELWSSSLLLSESGRRLVRQG 91 Query: 55 HLDYYRAGAQCAITASYQATPA-------GFAARG-----LDEAQSKALIGKSVELARKA 102 H D+ RAGA T +YQ A +D+A L VE+A++A Sbjct: 92 HDDWLRAGANVLSTVTYQCHYQAAYWPKGKMATNDKDSRVMDDAVVNTLWNDGVEIAQQA 151 Query: 103 REAYLAENPQAG------------TLLVAGSVGPYGAYLADGSEYRGDYHC-SVEAFQAF 149 + Y + V S G YGA LA+G+EY G+Y +V+ F Sbjct: 152 VKDYCHNQQRPHTLRQPELETSSVPRYVVASSGCYGAILANGAEYTGNYGPVTVDDLVHF 211 Query: 150 HRPRVEALLDAGADLLACETLPNFSEIEALAELLTA--------YPRARAWFSFTLRDSE 201 HR +V + D +A ET+P+ E AL +L + W S + R+ Sbjct: 212 HRRKVRRAVQLHPDGIAIETVPSLLECHALVQLFQPTNGAAPMLLNKTACWISLSCRNER 271 Query: 202 HLSDGTPLRDVVALLAGYP--QVVALGINCIALENTTAAL--------QHLHGLTVLPLV 251 L+DGTPL + +L+ P V A G+NC ++ + A + Q G LV Sbjct: 272 ELNDGTPLVAALNVLSQIPCTAVSAWGLNCCSVTHLPALVRILTQHVAQEASGKHRRGLV 331 Query: 252 VYPNSGEHYDAVSKTWHHHG--EHCAQLADYL--------PQWQAA------GARLIGGC 295 +YPNSGE +DAV+ TWH A +A + +W+ + LIGGC Sbjct: 332 LYPNSGELWDAVTGTWHTGTGCTAPAAMASEIVAVLRTVEDEWRRHRPTDPTPSILIGGC 391 Query: 296 CRTTPADIAALK 307 CRT+PA IAAL+ Sbjct: 392 CRTSPATIAALR 403 >UniRef50_B6AUX0 Homocysteine S-methyltransferase n=1 Tax=Rhodobacterales bacterium HTCC2083 RepID=B6AUX0_9RHOB Length = 298 Score = 200 bits (509), Expect = 5e-50, Method: Composition-based stats. Identities = 86/304 (28%), Positives = 124/304 (40%), Gaps = 26/304 (8%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 D++L DG M EL R + LWS +V+++ P L+ +V D++ AG+ A SY Sbjct: 3 DVMLFDGGMGQELVHRAGDKPTPLWSTQVMMDKPGLVADVSRDFFAAGSTVATLNSYAIQ 62 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 G+ E Q L +++ + A A+ G+ +AGS+GP A Sbjct: 63 RDRLVPVGI-EDQFDTLHSMALKEGQDAVAAH-------GSGRLAGSMGPLAA------S 108 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE-LLTAYPRARAWF 193 YR D H S + + + + DL+ CET+ + + TA F Sbjct: 109 YRPDIHPSADIAVPLYTEVAQKFV-GNVDLIVCETVVSLEHTRCILAGAKTANLPIYCAF 167 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVY 253 S + D L G P+ + A +A VVA+ NC A E AL L T LP Y Sbjct: 168 SVSDEDGSKLRSGEPVLEA-AQIAKDMGVVAVMANCSAPEVIPTALNELAK-TSLPFGAY 225 Query: 254 PNSGEHY--------DAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAA 305 N V AD++ W GA LIGGCC +PA IA Sbjct: 226 ANGFTKISDGFLKDRPTVDALTLRKDFSPDLYADHVMAWVDQGATLIGGCCEVSPAHIAE 285 Query: 306 LKAR 309 + R Sbjct: 286 IAKR 289 >UniRef50_A3JFK5 Putative uncharacterized protein n=1 Tax=Marinobacter sp. ELB17 RepID=A3JFK5_9ALTE Length = 303 Score = 200 bits (509), Expect = 6e-50, Method: Composition-based stats. Identities = 78/299 (26%), Positives = 128/299 (42%), Gaps = 24/299 (8%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 + ++LLDG + E+ R N++ +LWS V+ E P+++ VH D+ RAGA+ +Y A Sbjct: 2 RPVVLLDGGLGQEIYRRAANVSSALWSVAVMHEQPDVVTAVHSDFIRAGAKTLSLNTYAA 61 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 TP+ G Q A+ + EL +A +A + +AG + P Sbjct: 62 TPSRLLRHG-QLEQLAAIHQNAFELLGQAVKA------TGACVDIAGCLPPLA------G 108 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWF 193 Y+G S E + + V+ A AD+L ET+ N E A + Sbjct: 109 SYQGQPARSFEDLRDEYSVLVKQ--QAVADVLLIETMTNTLEACAACAAASEL-GKPYGV 165 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVY 253 +F L L G L + VA ++ Y A+ +NC E +AA+ L L + Y Sbjct: 166 AFRLEADGKLMSGETLAEAVAAVSPYS-PTAVMLNCCDPELISAAMPELVRLHPC-VGGY 223 Query: 254 PNSGEHYDAVSKTWHHHGEH------CAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 N+ + +A+++ ++ QW GA +IGGCC TP + + Sbjct: 224 ANAFKSVEALAQGGSVDALEARADISPQAYVAHVRQWLDDGATVIGGCCEITPEHVRHI 282 >UniRef50_D1Z559 Whole genome shotgun sequence assembly, scaffold_4 n=1 Tax=Sordaria macrospora RepID=D1Z559_SORMA Length = 357 Score = 200 bits (508), Expect = 6e-50, Method: Composition-based stats. Identities = 91/336 (27%), Positives = 142/336 (42%), Gaps = 44/336 (13%) Query: 15 DILLLDGAMATELEARG---CNLADSLWSAKVLVE-NPELIREVHLDYYRAGAQCAITAS 70 + +LDG + T LE + LWS+ +LV + + + H + +AGA TA+ Sbjct: 6 PVQILDGGLGTTLEDLHGITFSFETPLWSSHLLVSGEEDKLLDCHEAFQKAGANIISTAT 65 Query: 71 YQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLA 130 YQ + GFAA ++ + IGK R LA N VA ++GPYGA + Sbjct: 66 YQTSINGFAATKAPKSGAPDGIGKEGIPHFLNRAVVLAANAAGKEGKVALALGPYGATMI 125 Query: 131 DGSEYRGDY---HCSVEAFQAFHRPRVEALLDAG---ADLLACETLPNFSEIEALAELL- 183 +EY G Y H A + +H+ R++ D + +A ET+P EI A+ LL Sbjct: 126 PSTEYSGKYDPGHQDARALEEWHKKRLDLFKDVNTNQVNYIAFETVPRLDEIVAIRNLLS 185 Query: 184 -----TAYPRARAWF-SFTLRDSEHLSDGTPLRDVVALL----AGYPQVVALGINCIALE 233 T+ W S D E L DG+ + +VV G +GINC +E Sbjct: 186 TDKIPTSLRGRPVWISSLYPNDDEKLPDGSTVEEVVRAALTRREGLETPWGIGINCTKVE 245 Query: 234 NTTAALQHLHG-----------LTVLPLVVYPN--SGEHYDAVSKTWHHHGEHCAQLADY 280 + ++ + LV+YP+ +GE Y+ ++KTW A + Sbjct: 246 KLDSLVRRYEAALQSCIDNGEPMDWPSLVLYPDGTNGEVYNTINKTWELPPGQKQPEAPW 305 Query: 281 ----------LPQWQAAGARLIGGCCRTTPADIAAL 306 Q + ++GGCC+T+P I L Sbjct: 306 EVILTNVVGAARQRGKWKSIIVGGCCKTSPELIRKL 341 >UniRef50_A8TIL6 Methionine synthase I n=3 Tax=Proteobacteria RepID=A8TIL6_9PROT Length = 344 Score = 200 bits (508), Expect = 7e-50, Method: Composition-based stats. Identities = 76/307 (24%), Positives = 118/307 (38%), Gaps = 17/307 (5%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 + L LL ++ L+ DGAM T L A G DS VE+P+ + VH D+ AG+ Sbjct: 3 DCLTDLLAERGHLIADGAMGTNLFALGLETGDS--PELWNVEHPDRVATVHRDFLEAGSD 60 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP 124 +T S+ + + + + L + +AR+ +A+ A LVAGS+GP Sbjct: 61 IVLTNSFGGSSFRLKLHHAQD-RVRELNAAAAGIARREVDAHAA--STGRRTLVAGSIGP 117 Query: 125 YGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 G + A QA L + GAD+L ET+ E+ A Sbjct: 118 TGELFIPLGALTAEAAADAFAEQA------AGLAEGGADVLWIETMSAPEEVLAAV-AGG 170 Query: 185 AYPRARAWFSFTLRDSEHLSDG-TPLRDVVALLAGYPQVVALGINC-IAL-ENTTAALQH 241 A + T + G TP+ A VA+G NC + E L Sbjct: 171 ARTGLPIVVTMTFDTNARTMMGVTPVEFANFAQALEHTPVAIGANCGVGPAELVDTILGI 230 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 ++ N G ++ +A Y + AGAR++GGCC +T Sbjct: 231 TAAAPGAVVIAKGNCGIPQYVEGAIVYN--GSPEAMAAYAQLVRDAGARIVGGCCGSTAI 288 Query: 302 DIAALKA 308 + A+ Sbjct: 289 HVKAIAE 295 >UniRef50_C6UN88 Putative B12-dependent methionine synthase n=1 Tax=Candidatus Hodgkinia cicadicola Dsem RepID=C6UN88_HODCD Length = 1185 Score = 199 bits (507), Expect = 9e-50, Method: Composition-based stats. Identities = 75/324 (23%), Positives = 136/324 (41%), Gaps = 31/324 (9%) Query: 4 NNPLRAL--LDKQDILLLDGAMATELEA-------RGCNLADSLWSAKVLVENPELIREV 54 ++ L+AL + + L+LDGAM T+++ G ++ + + + P+++ V Sbjct: 9 SSALKALTAISSKRALVLDGAMGTQIQKFKLKPKHYGVEASNGN-NDALNMTQPKVVEGV 67 Query: 55 HLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAG 114 H Y AG+ T ++ + A G + L + +AR+A A QA Sbjct: 68 HAAYAAAGSDVLSTNTFCSCSVSQADYGTPYS-CSDLNARGCLIARRAC--LKAGFAQAR 124 Query: 115 TLLVAGSVGPYG--AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPN 172 + VAG +GP A + + + + +R + +ALL +GAD L ET+ + Sbjct: 125 RVFVAGVLGPTNKSASIPADASRPSHRDVTFDDLVLSYRQQADALLASGADALLVETVFD 184 Query: 173 FSE----IEALAELLTAYPRARAWF-SFTLRD-SEHLSDGTPLRDVVALLAGYPQVVALG 226 ++A + +Y + RA S T+ D S G + + + + + +G Sbjct: 185 TLNAKAGLKACIDASASYRKRRALVASATISDASGRTLSGQTI-EAFWVSVKHANLAGVG 243 Query: 227 INC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ 285 +NC + + L P+ VYPN+G + + + A L + Sbjct: 244 LNCALGPAQLSRHAAALALAAEAPIWVYPNAGLPNEMG-----KYTQGAKAFAHALKR-- 296 Query: 286 AAGA-RLIGGCCRTTPADIAALKA 308 G +GGCC +TP I+ LKA Sbjct: 297 CFGVASAVGGCCGSTPEHISELKA 320 >UniRef50_B6BT42 Homocysteine S-methyltransferase 4, putative n=1 Tax=Candidatus Pelagibacter sp. HTCC7211 RepID=B6BT42_9RICK Length = 305 Score = 199 bits (507), Expect = 9e-50, Method: Composition-based stats. Identities = 69/315 (21%), Positives = 124/315 (39%), Gaps = 34/315 (10%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 ++ LDK +++LDG ELE G + LW+ K +++P+ + +VH +Y ++GA Sbjct: 6 IKKKLDKNSVVILDGGNGGELEQIGAKMDKDLWAGKSAIDDPDKLFQVHENYIKSGADVI 65 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 + +Y TP G E ++ K+V++A KA + E + VAGSV G Sbjct: 66 TSNTYAITPISMKEYGY-EKFTQEWNKKTVDIALKAAASTERE------IAVAGSVSTSG 118 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 ++ + ++ L DAG DL+ E + + E ++ Sbjct: 119 SWDK----------LTKNEITPGFSEQLTILSDAGVDLIILEAMTSKDETVESIIECSSK 168 Query: 187 PRARAWFSFTL---RDSEHLSDG--TPLRDVVALLAGYPQVV----------ALGINCIA 231 W S + + L G + + A Y + + + Sbjct: 169 INLPVWLSISCAMNNEEGKLMHGYQESVTNSKAQFYDYLENSLLKFTQLHKGPILVAHSD 228 Query: 232 LENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARL 291 ++ T+ A++ L + + YPN+G Y + + W GA++ Sbjct: 229 IKVTSEAVKILKKIHKGSIGAYPNNG--YFEKPNWKLVDDISPSSYLEEAKSWVLNGAQI 286 Query: 292 IGGCCRTTPADIAAL 306 IGGCC P I A+ Sbjct: 287 IGGCCGVGPDKIKAI 301 >UniRef50_D1BTI0 Methionine synthase n=24 Tax=Actinomycetales RepID=D1BTI0_XYLCX Length = 1193 Score = 199 bits (507), Expect = 1e-49, Method: Composition-based stats. Identities = 62/305 (20%), Positives = 116/305 (38%), Gaps = 27/305 (8%) Query: 13 KQDILLLDGAMATELEARGCNLAD----SLWSAKVLVENPELIREVHLDYYRAGAQCAIT 68 + +++ DGAM T ++ + L D + + V P++I VH Y AG T Sbjct: 26 RSRVVVADGAMGTMIQEQDPTLEDYEGHEGCNEVLNVSRPDIIGAVHDAYLEAGVDAIET 85 Query: 69 ASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 ++ A + G+D + + L +AR +A+ + V GS+GP Sbjct: 86 NTFGANWSNLGDYGIDH-RIRELARAGAAIARSRADAFATPD---RPRWVLGSMGP---- 137 Query: 129 LADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA-----ELL 183 G++ H + ++ + LL+ GAD L ET + + +A Sbjct: 138 ---GTKLPSLGHTTYAHLRSTFAEQAAGLLEGGADALLIETSQDLLQAKAAVTAAHDAFA 194 Query: 184 TAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHL 242 R S T+ + + G+ + + L V +G+NC + + L++L Sbjct: 195 AVGRRVPVMVSVTVETTGTMLMGSEIGAALTALQAI-GVDTIGLNCATGPDKMSEHLRYL 253 Query: 243 HGLTVLPLVVYPNSGEHYDAVSKTWHH--HGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 + +P+ PN+G + E A A ++ ++ TTP Sbjct: 254 SQHSEMPVTSMPNAGLPELGPHGAVYPLSATELAAAHAQFVREFGLGLVGGCC---GTTP 310 Query: 301 ADIAA 305 +AA Sbjct: 311 EHLAA 315 >UniRef50_A8N5L5 Putative uncharacterized protein n=1 Tax=Coprinopsis cinerea okayama7#130 RepID=A8N5L5_COPC7 Length = 355 Score = 199 bits (507), Expect = 1e-49, Method: Composition-based stats. Identities = 87/358 (24%), Positives = 133/358 (37%), Gaps = 70/358 (19%) Query: 11 LDKQDILLLDGAMATELEAR-GCNLAD-SLWSAKVLVENPELIREVHLDYYRAGAQCAIT 68 + K I +LDG + T LE G ++ LWS + ++ +P + + H ++ AGA T Sbjct: 1 MPKPKIAILDGGLGTHLENIIGDEVSKGPLWSTQAVISHPLSVLKTHRNFINAGATIIET 60 Query: 69 ASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 A+YQA+ G GL E +++ L+ K+V LA++A A S+GP+GA Sbjct: 61 ATYQASLPGLIKSGLQEYEARELMWKAVSLAKEAAADSDASIA--------LSLGPFGAT 112 Query: 129 LADGSEYRGDYHC-------------------------SVEAFQAFHRPRVEALLDAGA- 162 L E+ G Y ++ A FH R+ A Sbjct: 113 LRPTQEFEGFYPPPYGPKAYHPEGPNTQAFDSNEAEARAIGALAQFHLDRLLVFSQNSAV 172 Query: 163 ----DLLACETLPNFSEIEALAELLTAYP----------RARAWFSFTLRDSEHLSDGTP 208 LA ETL E+ A+ + + W SF + P Sbjct: 173 WDSIQYLAFETLLLPREVIAIRKAVGLLRTHLFKEHRSFDKSWWISFVVPSDATNPSVLP 232 Query: 209 LRDVVALLAGYPQVVALGINCIALENTTA-------ALQHLHGLTVLPLVVYPNSGEHYD 261 L AL G+ A+GINC + + L+ L LV+YPN G YD Sbjct: 233 LVSS-ALCEGHDLPSAIGINCTSFGTLLPRTLELCRLVPRFRPLSQLGLVLYPN-GGTYD 290 Query: 262 AVSKTWHHHGEHCAQLADYLPQWQAAGA-----------RLIGGCCRTTPADIAALKA 308 ++ W + + G + GGCCRT P+ I+ Sbjct: 291 TTNQRWLPDPVDADRQWGLALRDVLTGVLSETGAEGWRELIAGGCCRTGPSHISQFAE 348 >UniRef50_A4WQF1 Homocysteine S-methyltransferase n=39 Tax=Alphaproteobacteria RepID=A4WQF1_RHOS5 Length = 357 Score = 199 bits (506), Expect = 1e-49, Method: Composition-based stats. Identities = 71/310 (22%), Positives = 118/310 (38%), Gaps = 21/310 (6%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRA 61 + L +L ++ L+ DGA T L G + + ++ P+ IR ++ A Sbjct: 22 KMTDALSRMLQTREWLMADGATGTNLFNMGLSSGEP--PELWNIDRPDNIRALYRAAVEA 79 Query: 62 GAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGS 121 G+ +T S+ A + + L + EL R+ +A T++VAGS Sbjct: 80 GSDIFLTNSFGGNAARLKLH-EAQGRVGELNRTAAELGREVADA------SGRTVVVAGS 132 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 +GP G A + FH + EAL GAD+L ET+ A Sbjct: 133 MGPTGEIFEPMGTLTHRM-----AVEIFH-EQAEALKAGGADVLWVETISAAE-EFKAAA 185 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQV-VALGINC-IALENTTAAL 239 + + + G +V L+ P +A G NC + + + Sbjct: 186 EAARLAGMPWCGTMSFDTAGRTMMGLTPAALVDLVTKLPNPPLAFGANCGVGASDLLRTV 245 Query: 240 QHLHGLT-VLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRT 298 LP++ N+G H+ +A+Y + AGAR+IGGCC T Sbjct: 246 LGFTAQGVELPVIAKGNAGIPKYHDGHI--HYDGTPDLMAEYAVLARDAGARVIGGCCGT 303 Query: 299 TPADIAALKA 308 P + A++A Sbjct: 304 MPEHLRAMRA 313 >UniRef50_Q4FMM0 Homocysteine S-methyltransferase n=2 Tax=Candidatus Pelagibacter ubique RepID=Q4FMM0_PELUB Length = 302 Score = 195 bits (496), Expect = 2e-48, Method: Composition-based stats. Identities = 73/307 (23%), Positives = 134/307 (43%), Gaps = 37/307 (12%) Query: 18 LLDGAMATELEARGCNLADSLWSAKVLV--ENPELIREVHLDYYRAGAQCAITASYQATP 75 +LDG M EL ARG +LWSA ++ E +L+ + HLD+ +AGA+ +TA++ Sbjct: 11 ILDGGMGQELLARGMKPNGTLWSANAVLKEEYHQLLLDTHLDFIKAGAEVIVTATFTTRR 70 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 + E + + L K+ E+A+KA+E Q +L+AG + P YL Y Sbjct: 71 IRLRDNKI-EDKFEYLNKKAGEIAQKAKE-------QHPNVLIAGGLPP--QYLT----Y 116 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 D E Q F+ LLD D + L + E + E + + Sbjct: 117 EEDTRPDDEIKQNFYDQ--AKLLDPYIDFFYLDVLSSVKEFKLAIEAIEEF-NKPYLIGA 173 Query: 196 TLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYPN 255 + + +L G + D++ + + ++ L ++C++ EN L+ + L +P N Sbjct: 174 HISEGINLPSGEKISDIINNI-KHNNLLGLILSCVSPENFYENLEEVKNL-GVPFGFKLN 231 Query: 256 SG---EHYDAVSKTW-------------HHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 + D + ++ +A+++ +++ AGA ++GGCC T Sbjct: 232 AFVTTNPKDGYTNSYNVSKTGNPNEFLGQRKDLTPELMANFVKKFKNAGATILGGCCETR 291 Query: 300 PADIAAL 306 P+ I + Sbjct: 292 PSHIKEM 298 >UniRef50_Q65V50 MHT1 protein n=3 Tax=Pasteurellaceae RepID=Q65V50_MANSM Length = 298 Score = 195 bits (496), Expect = 2e-48, Method: Composition-based stats. Identities = 82/311 (26%), Positives = 112/311 (36%), Gaps = 34/311 (10%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 I +LDG M+ EL R WSA L E P ++ VH D+ GA+ T SY Sbjct: 2 PITILDGGMSRELMRRNAPFRQPEWSACALYEEPSAVQAVHEDFIAHGAEVITTDSYAVV 61 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP-YGAYLADGS 133 P + K L + LA+ A + N T +AGS+ P +G+Y AD Sbjct: 62 PFHIGEQRF-HTDGKTLADLAGRLAKSAVK-----NSGVLTTKIAGSLPPMFGSYRADL- 114 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWF 193 E F +P ++ L D+ CET E ++ LL R W Sbjct: 115 -------IQPERFAEIAQPLIDGL-SPYVDIWLCETQSAIIEPVSIKALLPKDDR-PFWV 165 Query: 194 SFTLRDSE-----HLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQ------HL 242 SFTL D E L G ++ V + V A+ NC E AL Sbjct: 166 SFTLTDDELTCEPQLRSGETVKSAVEKMVDL-GVDAILFNCCQPEVIGEALAVTTATLTA 224 Query: 243 HGLTVLPLVVYPNSGEHYDAVSKTWHHHGE-----HCAQLADYLPQWQAAGARLIGGCCR 297 T + Y N+ + E + +W A GA +IGGCC Sbjct: 225 LNATHIQTGAYANAFAPQPKDATANDGLDEVRKDLDPPAYLAWAKKWTAQGASIIGGCCG 284 Query: 298 TTPADIAALKA 308 I L Sbjct: 285 IGVEYIETLAK 295 >UniRef50_C5RGW2 Methylenetetrahydrofolate reductase n=1 Tax=Clostridium cellulovorans 743B RepID=C5RGW2_CLOCL Length = 609 Score = 193 bits (492), Expect = 5e-48, Method: Composition-based stats. Identities = 54/298 (18%), Positives = 102/298 (34%), Gaps = 29/298 (9%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 + +L+ DGAM T A CN + + + I +H +Y +AGA T ++ Sbjct: 4 NERLLIFDGAMGTY-YASSCNNPLPKC-ELANIHDKKTILNIHKEYIKAGAGAIKTNTFG 61 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A D K I E+A++A E +LV +GP Sbjct: 62 ANKISLE---CDFDVMKEAIVSGYEIAKEATE--------GTDVLVFADIGPI------- 103 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 ++ ++ L GA ET + + ++E + Sbjct: 104 ------PFLEKVDLWVGYKEIIDIFLSLGASNFIFETFSSDEYLIEISEYIKEKNSKAFI 157 Query: 193 FS-FTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLV 251 + F + G + ++ + + A G NC + + + Sbjct: 158 LTEFAVSPEGVTRLGKSGKKLLNTMLKAKTIDACGFNCFSGPYHLLQYSKTLDIKDKTIS 217 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKAR 309 + PNSG ++ + + + A+ + + G ++GGCC TTP I + + Sbjct: 218 MMPNSGYPSMINNRVFFDNTK--EYFAEQMLEIARQGVTILGGCCGTTPEYIKEMVDK 273 >UniRef50_Q5KA93 Homocysteine S-methyltransferase, putative n=1 Tax=Filobasidiella neoformans RepID=Q5KA93_CRYNE Length = 381 Score = 193 bits (491), Expect = 6e-48, Method: Composition-based stats. Identities = 83/377 (22%), Positives = 142/377 (37%), Gaps = 87/377 (23%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 +IL+LDG M T LE+ G +++ LW ++ L NP++IR+VH Y + GA TA+YQ T Sbjct: 4 NILVLDGGMGTTLESLGVDISSPLWGSEALRTNPDVIRKVHEGYVQGGADLVETATYQLT 63 Query: 75 PAGFAAR-GLDEAQSKALIGKSVELARKAR-------EAYLAENPQAGTLLVAGSVGPYG 126 P +++ ++ V+L E + ++ V S GPYG Sbjct: 64 PQNLCDHLHCPREEAECILCSGVKLVASCIASCSSRNEEHNTKSKGGNKSKVVLSFGPYG 123 Query: 127 AYLADGSEYRGDY---------------------HCSVEAFQAFHRPRVEALLDAG---- 161 + L G EY G Y +++A H ++EA+ G Sbjct: 124 STLQPGQEYGGIYPPPFGPSTSTNAFPPDSNDEEEAAIQALAYHHLDKLEAISHDGAAWR 183 Query: 162 -ADLLACETLPNFSEIEALAELLTAY-----------------PRARAWFSFTLRDSEH- 202 + +A ET+P E+ + + + W + +H Sbjct: 184 EVEWIAFETIPVLHEVRGIRRAMAILRGKLSALYADGDNIDLWWEKKFWITSPFPMGQHP 243 Query: 203 --LSDGT--PLRDVVALLAGYPQVV--ALGINCIALENTTAALQHLHG------LTVLPL 250 L DG+ + V+ L P + +GINC + + Sbjct: 244 QLLPDGSHASIPQVIHSLFSGPDPIPNGIGINCTNPSYLHFLSSSFTSHLPFEFFGKVEM 303 Query: 251 VVYPNSGEHYDAVSKTW---HHHGEHCAQLADYLPQWQAAGARLIGG------------- 294 V+YP+ G+ YD ++ W E+ + A+ + A G R G Sbjct: 304 VIYPDGGQMYDTTTRAWVVAPQSPENAEKWAEVVGD-VAKGVR---GAEREGKGVWKGVV 359 Query: 295 ---CCRTTPADIAALKA 308 CC+++ +I AL+ Sbjct: 360 VGGCCKSSFDEIRALRR 376 >UniRef50_A4EKV4 Methionine synthase I n=4 Tax=Alphaproteobacteria RepID=A4EKV4_9RHOB Length = 339 Score = 193 bits (490), Expect = 8e-48, Method: Composition-based stats. Identities = 76/309 (24%), Positives = 114/309 (36%), Gaps = 21/309 (6%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 N L LL +D L+ DGA T L G D+ V+ I ++ AG Sbjct: 2 MTNALSNLLKTRDWLMADGATGTNLFNMGLMSGDA--PEMWNVDETAKIIALYKGAADAG 59 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 + +T S+ A + G E + K L + EL R+ +A ++VAGSV Sbjct: 60 SDIFLTNSFGANASRLKLHG-AEGRVKELNKAAAELGREVADA------SERVIVVAGSV 112 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G +A E + E L GAD+L ET+ A A Sbjct: 113 GPTGEIMAPMGSLT------HEIAVEMFHEQAEGLKAGGADVLWVETISAPE-EFAAASE 165 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYP-QVVALGINC-IALENTTAALQ 240 A + + + G D+V + Q G NC + + + Sbjct: 166 AFALADMPWCGTMSFDTAGRTMMGLTSADMVKKVGKLAHQPFGFGANCGVGASDLLRTVL 225 Query: 241 HLHGLTV-LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 LP++ N+G H+ A +ADY + GA +IGGCC TT Sbjct: 226 GFAAADPTLPIIAKGNAGIPKYHDGHI--HYDGTPALMADYAVLARDCGATIIGGCCGTT 283 Query: 300 PADIAALKA 308 P + A++ Sbjct: 284 PEHLRAMRE 292 >UniRef50_B8I637 Methylenetetrahydrofolate reductase n=2 Tax=Clostridium RepID=B8I637_CLOCE Length = 615 Score = 193 bits (490), Expect = 8e-48, Method: Composition-based stats. Identities = 60/301 (19%), Positives = 111/301 (36%), Gaps = 36/301 (11%) Query: 9 ALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAIT 68 + +D L DGA+ T + + E I +H +Y +AG T Sbjct: 33 NIFSNRDYFLFDGAIGTY---YSLKYRSNTPCELANINERENIFNIHSEYIQAGVNAIKT 89 Query: 69 ASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG-- 126 ++ A G ++++ + +I ++A +A ++V +GP Sbjct: 90 NTFSANRFSL---GCNQSEVEKIIKSGYDIAVQAC--------SGQEVVVFADIGPIPDE 138 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT-A 185 + EY V+ L+ GA ET N + +A + Sbjct: 139 KGINPKEEYI---------------KIVDIFLECGAKNFLFETFANTDILIGVAAYIRLR 183 Query: 186 YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHG 244 P A SF + + +G D++ + V A+G+NC + ++ Sbjct: 184 LPEAVVVTSFAVYPDGYSKEGLFYVDLMDKMYASGLVDAVGLNCISGPAHMYRLIKK-AD 242 Query: 245 LTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 + +++ PNSG Y + + ++ A+ L + G ++ GGCC TTP IA Sbjct: 243 IRGKSIIIMPNSG--YPGSERGRTVYSDNSEYYAEKLLDLKNLGVKIFGGCCGTTPKHIA 300 Query: 305 A 305 A Sbjct: 301 A 301 >UniRef50_B0MM61 Putative uncharacterized protein n=1 Tax=Eubacterium siraeum DSM 15702 RepID=B0MM61_9FIRM Length = 414 Score = 192 bits (489), Expect = 1e-47, Method: Composition-based stats. Identities = 65/305 (21%), Positives = 126/305 (41%), Gaps = 26/305 (8%) Query: 4 NNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGA 63 +NP+ + + +LLDG T LE G + ++ +A+ + NPE + E+ + AG+ Sbjct: 3 SNPVSQDIPIRLPILLDGGTGTGLEKYGYD--HTVSTAQFVCANPEALIELQQGFLDAGS 60 Query: 64 QCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVG 123 Q TA++ A A G+ E +++ L + ++ + L+AG + Sbjct: 61 QILYTATHGANCENLKAYGV-EDKTEQLNAAAAKI---------TYDSFHEKALIAGCLS 110 Query: 124 PYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 G Y+ +Y + +R +V+AL D+ ET+P + A L Sbjct: 111 STGLYIEPYGDYT------FTEIMSVYRQQVKAL-SPYCDMFVIETVPALWNMRAAV-LA 162 Query: 184 TAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLH 243 + + + + GT + + +L + A G+NC + + + + Sbjct: 163 CKKENKPIIATMKVDEDGETAIGTNVLCTLLVLQAM-GISAFGLNCTSADLCPDIISEIA 221 Query: 244 GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADI 303 +PL+V P++ D ++ + A + + +GA + GGCC T I Sbjct: 222 PYAKIPLIVKPSAVYEQDGERQSIS-----PEEFAFAVKKSVLSGAEIAGGCCGTGKEHI 276 Query: 304 AALKA 308 AAL+ Sbjct: 277 AALRE 281 >UniRef50_C9SAQ6 Homocysteine S-methyltransferase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SAQ6_VERA1 Length = 355 Score = 191 bits (486), Expect = 2e-47, Method: Composition-based stats. Identities = 86/345 (24%), Positives = 134/345 (38%), Gaps = 58/345 (16%) Query: 14 QDILLLDGAMATEL-EARGCNLA--DSLWSAKVLVENPELIREVHLDYYRAGAQCAITAS 70 +L+LDG + T L + G LWS+ +LV + + + D+ +TA+ Sbjct: 7 NKVLILDGGLGTSLGDKYGVRFDKSTPLWSSHMLVSDQDTLLACQKDFGDVPVDIILTAT 66 Query: 71 YQATPAGFAAR-------GLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVG 123 YQ + GFA G+D + + ++ +A A + + VA SVG Sbjct: 67 YQFSIHGFANTRTAQFPDGIDRTKIASYARDAIAIAHSAGKENGGQ--------VALSVG 118 Query: 124 PYGAYLADGSEYRGDY---HCSVEAFQAFHRPRVEALLDAG-----ADLLACETLPNFSE 175 PYGA + G EY G Y H + E A+H R +AG +A ET+P E Sbjct: 119 PYGACMIPGQEYTGKYDLEHDTPEDLAAWHLERFRIFEEAGGFSSPVSYIAVETMPRLDE 178 Query: 176 IEALAELLTAYP----RARAWFSFTLR-DSEHLSDGTPLRDVVALLA----GYPQVVALG 226 I A + L W + + L DG + V + Q +G Sbjct: 179 IVAARKALDDLGAKAANTPFWIACVFPGEEMALPDGASISSAVDAMLNPAVARSQPWGIG 238 Query: 227 INCIALENTTAALQHL-----------HGLTVLPLVVYPNS--GEHYDAVSKTWHHHGEH 273 INC + + H H LV+YP+ GE Y+ ++TW Sbjct: 239 INCTKIWKLKELIAHFEAAVADQVQAGHVNEAPALVLYPDGTDGEVYNTTTQTWELPAGG 298 Query: 274 CAQLADYLPQW----QAAGAR------LIGGCCRTTPADIAALKA 308 Q A + Q + A R ++GGCC+ + A +A L+ Sbjct: 299 KVQGAPWEEQLAEIVRDANTRGKWKQIVVGGCCKASHAHLARLRD 343 >UniRef50_B7G6P4 Predicted protein n=2 Tax=cellular organisms RepID=B7G6P4_PHATR Length = 346 Score = 191 bits (485), Expect = 4e-47, Method: Composition-based stats. Identities = 74/332 (22%), Positives = 126/332 (37%), Gaps = 51/332 (15%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 + +LLDG E++ RG WSA L E+P+++R VH + AG+ T +Y Sbjct: 12 NRPFILLDGGTGREIQQRGGPFRQPEWSALALYEDPDIVRAVHESFLNAGSTAITTNTYA 71 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY-GAYLAD 131 P + + L ++ LA +A+ + + GS+ P G+Y Sbjct: 72 LVPYHIGSDRF-RKDAPRLFSLAISLAAEAK-------GDRQHVQILGSIPPVCGSY--- 120 Query: 132 GSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE-----------IEALA 180 E + + ++ + P + D ET+ + E ++A+A Sbjct: 121 --EPQSFDEATAKSILDWFMPVL--GDSPLVDAYLLETVGSTREARFYLQYMQSFVKAVA 176 Query: 181 ELLTAYPR------ARAWFSFTL------RDSEHLSDGTPLRDVVALLAGYPQVVA---- 224 E L + W SF + + HL G L V L + A Sbjct: 177 ESLDSLSNGTLAREKPVWLSFCIASHPGATQTPHLLTGETLTQAVHALIEEGLLTAATVP 236 Query: 225 -LGINCIALENTTAALQHLHGLTV---LPLVVYPNSG--EHYDAVSKTWH--HHGEHCAQ 276 + +NC ++ A+Q LH + + + YPN+ +A + T + + Sbjct: 237 VVLVNCCDVKLVLNAVQELHAVLSPLGIRVGAYPNAFSIPPPNAANHTLRQVDYNVTPGR 296 Query: 277 LADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 A W AGA ++GGCC P I AL + Sbjct: 297 WAATAKSWINAGASVVGGCCGVGPKYITALAS 328 >UniRef50_UPI00016C0A13 5-methyltetrahydrofolate--homocysteine methyltransferase, putative n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016C0A13 Length = 276 Score = 190 bits (483), Expect = 6e-47, Method: Composition-based stats. Identities = 63/295 (21%), Positives = 113/295 (38%), Gaps = 29/295 (9%) Query: 15 DILLLDGAMATEL-EARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 +I LDGA+ + L + N+ ++ + +P+L+ ++H +Y AGAQ + ++ Sbjct: 2 NITFLDGALGSNLLQTASANV------FELNLTHPDLVAQLHREYVAAGAQIVASNTFGV 55 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 A LI +++A A T VA +GP A L Sbjct: 56 NRISAAKTKYA---VGELIEAGLQIAFDAI-------SDTDTAKVAFDIGPLAALLEPFG 105 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWF 193 + S E + + + + + + ET + E+ LA + Sbjct: 106 DL------SEEECSEIYAEILASGISQKPNYIFFETFMDV-EMLKLAVAVADNYDVPILA 158 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIA-LENTTAALQHLHGLTVLPLVV 252 + + G + D +A ++ + VVA+G+NC N +Q + P+++ Sbjct: 159 AMSFLPVGKTIMGNSVDDFLAAMSKFKNVVAVGLNCSDTPTNLAKVVQEFAAKSSWPIII 218 Query: 253 YPNSGEHYDAVSK-TWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 PN+G + ++ E A Y Q A +GGCC TTP I L Sbjct: 219 KPNAGLPQSVDGEISYATDAEFFAAEMAYALQIPNA---YVGGCCGTTPLHIQQL 270 >UniRef50_B0PF81 Methylenetetrahydrofolate reductase n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PF81_9FIRM Length = 582 Score = 188 bits (479), Expect = 2e-46, Method: Composition-based stats. Identities = 61/292 (20%), Positives = 102/292 (34%), Gaps = 36/292 (12%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 L DGA T + D + P+ + ++H +Y +G T ++ A Sbjct: 5 RPFLFDGAFGTYYFS---KTGDEAPCELANLTAPQTVLDIHREYAASGCAALKTNTFAAN 61 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 P + +I LA++A + V +G Sbjct: 62 PVSIPDS----VRLNEVIAAGWSLAQRAAQE--------NGARVFADIG----------- 98 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA-YPRARAWF 193 + +A + V L+ GA ETL + +++ L+ P A Sbjct: 99 -----GICADTAEADYLTVVRHFLELGAQNFLFETLACYQDVQRAVGLIRQSVPDATVIV 153 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLVV 252 SF + + G R + PQV A+G+NC + + L+ L G V P+ Sbjct: 154 SFAVSQDGYSRRGLYCRALFDQAESDPQVDAVGLNCSCGPSHMRSLLRAL-GQRVKPVAA 212 Query: 253 YPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 PN+G + + ++ A L GA ++GGCC TTP I Sbjct: 213 MPNAGYPSSLNGRVF--FEDNAGYFAQQLSALYMDGADILGGCCGTTPQHIR 262 >UniRef50_A2R696 Contig An15c0240, complete genome n=9 Tax=Leotiomyceta RepID=A2R696_ASPNC Length = 353 Score = 188 bits (478), Expect = 2e-46, Method: Composition-based stats. Identities = 85/357 (23%), Positives = 141/357 (39%), Gaps = 66/357 (18%) Query: 11 LDKQDILLLDGAMATELEAR----GCNLADSLWSAKVLVENPELIREVHLDYYR-AGAQC 65 + K IL+LDG + T L+ + LWS+ +++ +P + D+ A Sbjct: 1 MAKTPILILDGGLGTSLQDHYNITFSSSTTPLWSSHLMISDPSTLLSCQRDFTTTAAVDV 60 Query: 66 AITASYQATPAGFAAR-------GLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLV 118 +TA+YQ +P GF G+ + ++++A +A + A V Sbjct: 61 LLTATYQVSPEGFQRTKTPSHPTGIPRESIAGYLRTALDVAGQAVQNTSAS--------V 112 Query: 119 AGSVGPYGAYLADGSEYRGDY---HCSVEAFQAFHRPRVEALLDAG---------ADLLA 166 A S+GPYGA + G EY G Y H + E +H R+ D +A Sbjct: 113 ALSLGPYGACMIPGQEYSGKYDGEHDTEEKLWRWHTDRLGLFNDEAMEGMRLGERVKYIA 172 Query: 167 CETLPNFSEIEALAELL---TAYPRARAWFS--FTLRDSEHLSDGTPLRDVVAL----LA 217 ET+P E+ A+ + W + F + D + L DG+ + +VV + Sbjct: 173 METVPRIDEVRAVRRAVGSSRFCEGIPFWVACVFPIEDKDTLPDGSTVDEVVEAALLPIE 232 Query: 218 GYPQVVALGINCIALENTTAALQHLHGL-----------TVLPLVVYPNS--GEHYDAVS 264 G +GINC L ++ LV+YP+ GE Y+ + Sbjct: 233 GGATPWGIGINCTKLHKLPRLVKLFGDAVERLLRDGRIQERPALVLYPDGTQGEVYNTAT 292 Query: 265 KTWHHHGEHCA---------QLADYLPQWQAAG---ARLIGGCCRTTPADIAALKAR 309 +TW + QLA + A G + L+GGCC+ + DI L+ + Sbjct: 293 QTWEKVQDKSGAADSRPWEVQLAQVVNDASATGQFSSILVGGCCKASFNDIKRLREQ 349 >UniRef50_B1KCG4 Homocysteine S-methyltransferase n=52 Tax=Proteobacteria RepID=B1KCG4_BURCC Length = 313 Score = 188 bits (478), Expect = 2e-46, Method: Composition-based stats. Identities = 84/313 (26%), Positives = 113/313 (36%), Gaps = 37/313 (11%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 I +LDG M EL G WSA L+E P + H + AGA SY P Sbjct: 4 ITVLDGGMGRELARMGAPFRQPEWSALALMEAPHYVGLAHDAFIAAGADVITANSYAVVP 63 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 + AR+A + + + VAGS+ P G Y Sbjct: 64 FHIGEQRFRRDGVALAALAGQL-ARQAADRAV------RPVRVAGSLPPTG------GSY 110 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 R D + A A V+ L D DL ET EI+A+ L A R W SF Sbjct: 111 RPDLFDAARA-DAILATLVDGL-DPYVDLWLAETQSLTGEIDAVRRALGA-NRKPLWVSF 167 Query: 196 TLRD--------SEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQH------ 241 TLRD L G L + + + AL NC E AA++ Sbjct: 168 TLRDDVGADTGAGPVLRSGQALDEAIDAAVS-ARARALLFNCSQPEAMGAAIETVQRTLA 226 Query: 242 -LHGLTVLPLVVYPNSGEHYDAVSKT-----WHHHGEHCAQLADYLPQWQAAGARLIGGC 295 + L + Y N+ A ++ A + QW A GA+++GGC Sbjct: 227 GMGAGAALMIGAYANAFPPQRADARANEELDVLRGDIDPPGYAKWAEQWLALGAQIVGGC 286 Query: 296 CRTTPADIAALKA 308 C P IAAL+ Sbjct: 287 CGIGPGHIAALRD 299 >UniRef50_B6KB25 Homocysteine S-methyltransferase-1 n=3 Tax=Toxoplasma gondii RepID=B6KB25_TOXGO Length = 434 Score = 186 bits (474), Expect = 6e-46, Method: Composition-based stats. Identities = 98/327 (29%), Positives = 140/327 (42%), Gaps = 67/327 (20%) Query: 15 DILLLDGAMATELEARGCNL-ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 DILLLDG + T L A G D LW++K ++ P+L+R H D++ AGA AITA+YQA Sbjct: 9 DILLLDGGLGTHLRALGAEFHGDPLWASKAVLSAPDLVRRAHFDFFDAGADVAITATYQA 68 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAR--------------EAYLAENPQAGTLLVA 119 + GFA GL + + + ++ LA +AR E E P+ L A Sbjct: 69 SLTGFAQIGLSPSTAHDAVALAINLAAEARRLAEEGDVSARSFGEERENEGPEVDALRNA 128 Query: 120 G----------------------------SVGPYGAYLADGSEYRGDYHCSVEAFQAFHR 151 S G YGA L G+EYRG+Y S + F +HR Sbjct: 129 ATSDTDSVQQGNARDADRRYRRRNRKILVSNGSYGASLGGGAEYRGNYGVSEKTFHDYHR 188 Query: 152 PRVEALLDAG--ADLLACETLPNFSEIEALAELLTAYP--RARAWFSFTLRDSEHLSDGT 207 R++A L+ D + ETLP +E +A+ LL +P R + W +FT + L+ G Sbjct: 189 WRLQAALEQEHLVDGVVFETLPEHAEAKAIVSLLREFPSLRGKTWLAFTCKSPTELAGGE 248 Query: 208 PLRDVVALLAGYPQVV----ALGINCIALENTTAA-------------LQHLHGLTVLPL 250 R VVA + +G+NC + T L+ L + Sbjct: 249 DFRSVVADVLKQDGADQYISGIGVNCAPISTTVPLLCSPPLRDSLAASLEKTRDPWSLQV 308 Query: 251 VVYPN---SGEHYDAVSKTWHHHGEHC 274 V YPN + D SK + E C Sbjct: 309 VCYPNNEAARNTKDCSSKDFESQEESC 335 Score = 52.6 bits (125), Expect = 2e-05, Method: Composition-based stats. Identities = 13/33 (39%), Positives = 18/33 (54%) Query: 276 QLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 LA +P W G +GGCC T P D+ ++A Sbjct: 394 PLASRVPAWLNGGVTAVGGCCGTGPEDLKEIRA 426 >UniRef50_A0Z513 Putative uncharacterized protein n=1 Tax=marine gamma proteobacterium HTCC2080 RepID=A0Z513_9GAMM Length = 306 Score = 186 bits (472), Expect = 1e-45, Method: Composition-based stats. Identities = 76/304 (25%), Positives = 110/304 (36%), Gaps = 31/304 (10%) Query: 16 ILLLDGAMATELEARGCNLA-DSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 I LLDG M EL R LWS +V+++ PEL+ VH D+ AGA+ +Y T Sbjct: 5 ITLLDGGMGQELIRRSSAAKPHPLWSLQVMMDEPELVANVHRDFCLAGARVICLNTYSVT 64 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 G + L+ + +LAR +A + V S+ P A Sbjct: 65 RHRL-QMGNELPDLPELLKHAGDLARAGIQASGLHG-----IDVVASLPPLTA------S 112 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 Y S + ++ +E L D ETL + +E EA+ + Sbjct: 113 YLKQSPLSPTQMKDEYKELME-LQRHHVDGFLAETLSSVAEGEAVLRAAQEAGTGVH-LA 170 Query: 195 FTL--RDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVV 252 FT+ D L G L D + + + +NC E L + T + Sbjct: 171 FTVQDEDGTLLRSGELLEDALRACVPLKPLSVI-LNCSIPEAIDQGLPLVAQATEI-FGA 228 Query: 253 YPNS---------GEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADI 303 Y N G D ++ A D QW GA ++GGCC PA I Sbjct: 229 YANGFHSVTALKPGGTVDVLTA---REDLTPAAYTDMSLQWLELGASILGGCCEVGPAHI 285 Query: 304 AALK 307 AL Sbjct: 286 EALA 289 >UniRef50_C0EVI7 Methylenetetrahydrofolate reductase n=1 Tax=Eubacterium hallii DSM 3353 RepID=C0EVI7_9FIRM Length = 638 Score = 186 bits (472), Expect = 1e-45, Method: Composition-based stats. Identities = 67/312 (21%), Positives = 119/312 (38%), Gaps = 30/312 (9%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 +R L+ LL DGAM T ++ + + S + + NP L+RE+H Y + GAQ Sbjct: 5 IREYLENHK-LLTDGAMGTYFDS--IEKENYICSEEANITNPALVREIHRSYVKNGAQLL 61 Query: 67 ITASYQATPAGF------AARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 + ++ A F A + K LI +LA++ + E + A Sbjct: 62 RSNTFLANEGTFLSLTQAKAEAFENITLKQLIIAGYQLAKETAQEVYQEEY---PIFAAA 118 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 +GP + Q ++ ++ L+AGAD+ ET P+ + +A Sbjct: 119 DIGPI---------LEERDSEEADILQQYY-EICDSFLEAGADIFVLETFPDTQYVLKMA 168 Query: 181 ELLTA-YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAA 238 E + P A F+L + + G + ++ + G+NC + + Sbjct: 169 EYIRKSCPEAFIIGQFSLTPTGYSRTGFHYKTILQEATQSGLLDGAGLNCGVGAAHMKKF 228 Query: 239 LQHLHGLTVLP----LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGG 294 L+ +P L PN G + + + L + G +++GG Sbjct: 229 LKSYIEEFGVPEDMVLTSLPNCGYPQIVRGHAV--YSDSVPYFGEKLGEISELGVQVLGG 286 Query: 295 CCRTTPADIAAL 306 CC TTP I + Sbjct: 287 CCGTTPEYIGEI 298 >UniRef50_Q4DI99 Homocysteine S-methyltransferase, putative n=2 Tax=Trypanosoma cruzi RepID=Q4DI99_TRYCR Length = 410 Score = 185 bits (471), Expect = 1e-45, Method: Composition-based stats. Identities = 104/393 (26%), Positives = 147/393 (37%), Gaps = 105/393 (26%) Query: 16 ILLLDGAMATELEARGCNLAD--SLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 +L+ DGAM T LE+ + A S+WS+ VL+ +L++ H Y AG +T +YQ Sbjct: 9 VLIKDGAMGTLLESWDVDYAKAGSMWSSSVLLSEMDLVKRAHRAYIDAGCDVLLTCTYQM 68 Query: 74 TPAGFAARGLDEAQSKALIGKSVELAR---------------KAREAYL----------- 107 G AA + + L+ ++V+ AR A+E Sbjct: 69 HEEGCAASKVTMCE---LVDRAVQAARHTMPQRKQKGLTEESTAKERRTGGIDVFRYALS 125 Query: 108 --AENPQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALL------- 158 +N Q +L+AGS+GPYG+ L G EY G+Y AFH R+EA L Sbjct: 126 SIKDNGQERVVLLAGSLGPYGSSLPGGQEYLGEYSIHEAVINAFHARRLEAFLCNVGEKH 185 Query: 159 DAGADLLACETLPNFSEIEALA------ELLTAYPRARAWFSFTLRD------------- 199 D L ET P E + E+L P ++ + +++ Sbjct: 186 AFKVDFLLLETFPRLDEALGILSFVNQHEILRTAPFCFSFIAVPVKNPLPENADDDALDN 245 Query: 200 -------SEHLSDGTPLRDVVALLAGY--PQVVALGINCIALENT----TAALQHLHGLT 246 S L DG ++ L G +V +G NC TA L T Sbjct: 246 WWNAAASSIRLPDGNTFEGALSELRGNCGTALVGMGCNCSGPLEVSLVATALLHKKRQDT 305 Query: 247 VLPLV--VYPNSGEHY-DAVSKTWHHHGEHCA----QLADYLPQWQAAGARLI------- 292 PLV +YPNSGE + D K + A + D G LI Sbjct: 306 EGPLVLLLYPNSGEKFTDGQWKKPLQQIQTSAAERLSMRDLKRILARGGGNLITFMKFLL 365 Query: 293 -------------------GGCCRTTPADIAAL 306 G CCR+TP DIAAL Sbjct: 366 QLLQQRPEATDWLFEIIVCGACCRSTPEDIAAL 398 >UniRef50_D2W5I3 Predicted protein (Fragment) n=2 Tax=Naegleria gruberi RepID=D2W5I3_NAEGR Length = 661 Score = 184 bits (467), Expect = 4e-45, Method: Composition-based stats. Identities = 85/337 (25%), Positives = 135/337 (40%), Gaps = 69/337 (20%) Query: 11 LDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG-AQCAITA 69 L + IL+LDG ++T + G L SLW A L+ENP+ I +VH DY G ++ Sbjct: 328 LVDRKILILDGGISTYMTELGLELNGSLWGANYLLENPKAIAKVHSDYVHEGLCDICTSS 387 Query: 70 SYQATPAGFAARGLDEAQSKAL------IGKSVELARKAREAYLAENPQAGTLLVAGSVG 123 SYQ + G AA + + + + SV++ARK + LVA SV Sbjct: 388 SYQISQEGLAADHVSMKEEERIELASRMFRDSVQIARKVV--------REKEKLVAASVS 439 Query: 124 PYGA----YLADGSEYRGDYHCSV------------------------------EAFQAF 149 +GA L + EY GDY + F Sbjct: 440 CFGASISNLLGEAKEYFGDYLDKDVDSNSGHYVHKFVKQLSEKLGETLEKSGMEQVIYDF 499 Query: 150 HRPRVEALLDAGADLLACETLPNFSEIEALA-----ELLTAYPRA--RAWFSFTLRDSEH 202 H PRV L+ A D + ET+P E+E L ++L + + SF +D H Sbjct: 500 HYPRVRELILAEPDFILLETMPVLKEVEILCDRVIPDILKELNKKGIKVMISFYCKDGLH 559 Query: 203 LSDGTPLRDVVALLA------GYPQVVALGINCIALENTTAALQHLHGL--TVLPLVVYP 254 G + V + ++ A+G NCI+ ++++H + +++YP Sbjct: 560 TGHGESIEKCVEYVNQDRFNPSLFEIFAVGANCISPSIVPILIENIHTHLRKDISIILYP 619 Query: 255 NSGEHYDAVSKTWHHHGEHCA-----QLADYLPQWQA 286 NSGE YD ++K+W ++ +W Sbjct: 620 NSGEIYDNLTKSWSIPQGGLDWLYDRDFIPFIKKWSE 656 >UniRef50_Q5UEY6 Putative homocysteine S-methyltransferase family protein n=1 Tax=uncultured alpha proteobacterium EBAC2C11 RepID=Q5UEY6_9PROT Length = 309 Score = 183 bits (464), Expect = 8e-45, Method: Composition-based stats. Identities = 72/308 (23%), Positives = 120/308 (38%), Gaps = 21/308 (6%) Query: 9 ALLDKQDIL---LLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQC 65 L+ K++ L +LD ++TELE RG + + WS V +++ E + E H+ Y AGA Sbjct: 7 ELIKKREQLLPIILDSGVSTELERRGAKMRNGQWSGCVAIDDYEKLVETHIAYIEAGADI 66 Query: 66 AITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY 125 SY ++ GL + + + + ++ A +ARE + VAGS+ + Sbjct: 67 ITVNSYASSRLMLGPAGLGD-EVERINRLNISAAIEAREK------TGANVSVAGSIS-H 118 Query: 126 GAYLADGSE-YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 DG E + S E + + + G DL+ E + + + L Sbjct: 119 ALPFTDGVEGAKQQPDISPEELSNCYGEMISIFENKGVDLILLEMMSIPARMAPLFNCAN 178 Query: 185 AYPRARAWFSFTLRDSEHLSDGTPLRDV------VALLAGYPQVVALGINCIALENTTAA 238 W + + L+ T D + + A A+GI +++ AA Sbjct: 179 K-SSLPIWCGLSAKRETPLAALTSWHDTSVSFEDIVIQACQYDFDAIGIMHTSVDAIEAA 237 Query: 239 LQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRT 298 L + L+ YP+SG Y L +Y WQ +G + GGCC Sbjct: 238 LVVIKNHFSGMLMAYPDSG--YFVAPNWQFEDIIEPHALVEYAKGWQKSGCSIFGGCCGL 295 Query: 299 TPADIAAL 306 P AL Sbjct: 296 GPEHTTAL 303 >UniRef50_B0DTQ2 Predicted protein n=1 Tax=Laccaria bicolor S238N-H82 RepID=B0DTQ2_LACBS Length = 418 Score = 183 bits (464), Expect = 9e-45, Method: Composition-based stats. Identities = 92/384 (23%), Positives = 143/384 (37%), Gaps = 77/384 (20%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEA-RGCNLADSLWSAKVLVENPELIREVHLDYYRA 61 +N A++D + + T LE ++ LWSA + +PE + HL + A Sbjct: 31 RNARFDAMIDAMNAVRRIWMQGTTLEDVFHKSIKTPLWSATLTETDPETVIAAHLAFLEA 90 Query: 62 GAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLV--A 119 G+ +T++YQ F G EA + L+ KSVELA +A+ +LA+NP + A Sbjct: 91 GSLVIMTSTYQRAFETFERAGYGEADAVTLMNKSVELASEAKSRFLAQNPSITATYIKIA 150 Query: 120 GSVGPYGAYLADGSEYRGDYHCSV-----------------------------EAFQAFH 150 ++GP+GA L E+ G Y ++ +FH Sbjct: 151 LALGPFGATLTTAQEFSGYYPPPYGPQEFTPDLDGTNTNAFSAEESEAEAVAVDSLASFH 210 Query: 151 RPRVEALLDAG----ADLLACETLPNFSEIEALAELLTAYPR---ARAWFSFTLRDS--- 200 R+ + D++ ET+P EI A+ + P W + D Sbjct: 211 LRRLRVFCNHPSWDLVDVIVFETVPLVREIAAIRRAVGMLPEFAMKSWWVATVWLDGVFL 270 Query: 201 -EHLSDGTPL--RDVVALL-----AGYPQVVALGINCIALENTTAALQHLH--------- 243 E + G L DVV L P +G+NC +E +Q Sbjct: 271 QESVPGGERLLAADVVDALLRDASPANPVPTGIGVNCTQIEYYPEIIQAHRIAFNALLLS 330 Query: 244 -----GLTVLPLVVYPNSGEHYDAVSKTWHHHG-------------EHCAQLADYLPQWQ 285 LVVY N G YD ++ W G + LA ++ Sbjct: 331 QVGDSKFARPRLVVYSNGGVKYDPIAHVWLDSGVAHRGGTGKAQWVKELVSLAKEEGKFG 390 Query: 286 AAGARLIGGCCRTTPADIAALKAR 309 + ++GGCC+T P DI AL Sbjct: 391 SWAGIVVGGCCKTAPDDIHALAEE 414 >UniRef50_A4R5G4 Putative uncharacterized protein n=1 Tax=Magnaporthe grisea RepID=A4R5G4_MAGGR Length = 374 Score = 181 bits (461), Expect = 2e-44, Method: Composition-based stats. Identities = 94/369 (25%), Positives = 150/369 (40%), Gaps = 74/369 (20%) Query: 15 DILLLDGAMATELEAR-GCNL--ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 DI +LDG + T LE R G A LWS+ +LV + E ++ ++ AGA +TA+Y Sbjct: 3 DIKILDGGLGTTLEDRFGVVFTHAKPLWSSDLLVSDQETLQACQREFAAAGADVLLTATY 62 Query: 72 QATPAGFAARGLDEA--------QSKALIGKSVELARKAREAYLAE-------------N 110 Q + FA E + +VE+A KA A A Sbjct: 63 QVSVEAFARTKTPEHPDGIAPSSAMLPYLRGAVEIAEKAAAAAAAAAAAAAAAPRNETSA 122 Query: 111 PQAGTLLVAGSVGPYGAYLADGSEYRGDY---HCSVEAFQAFHRPRVEALLDAGADL--- 164 P +A + GPYGA + G EY G Y H + +A +H R+ AG D+ Sbjct: 123 PSPQPAELALACGPYGAAMTPGQEYTGAYDAAHSTPDALSRWHLDRLALYAAAGEDVPGR 182 Query: 165 ---LACETLPNFSEIEALAELLTAYP--------RARAWFSFTL-RDSEHLSDGTPLRDV 212 +A ET+PN +E+ A+ + +T +R W + E L+DG+ + V Sbjct: 183 CAYVAFETVPNLAEVWAVRDAITRLRQDASCSRFPSRFWICCVFPHEDERLADGSSVDQV 242 Query: 213 VALL-------------AGYPQVVALGINCIALENTTAALQHLHG----------LTVLP 249 V + +GINC + ++ +T +P Sbjct: 243 VEAMLAARGGGENGGAKESLALPWGIGINCTKIYKLEGLIKSFERSISGLKAKGVITNVP 302 Query: 250 -LVVYPN--SGEHYDAVSKTWHHH---GEHCAQLADYLPQWQAAGA---RLIGGCCRTTP 300 LV+YP+ +GE Y+ ++ W +L + ++ G L+GGCC+ P Sbjct: 303 ALVLYPDGTNGEVYNTTTQKWEAPQVVQGAGPKLTQIVNDTKSRGVFTSFLVGGCCKANP 362 Query: 301 ADIAALKAR 309 +I L+ R Sbjct: 363 QNIKDLRNR 371 >UniRef50_A9QPD6 Methylenetetrahydrofolate reductase n=1 Tax=Methylacidiphilum infernorum V4 RepID=A9QPD6_METI4 Length = 617 Score = 179 bits (454), Expect = 1e-43, Method: Composition-based stats. Identities = 68/310 (21%), Positives = 126/310 (40%), Gaps = 24/310 (7%) Query: 1 MSQNNPLRALLDK--QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDY 58 M + L+D+ + +L+ DGA+ T L + G + + ++ + P LI +VH DY Sbjct: 1 MPWEKRMATLIDRLNESLLIGDGALGTYLYSLG--VPRNYCIEELSLSQPYLIEKVHKDY 58 Query: 59 YRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLV 118 AGA+ + +A + L E + K ++ S+ LA+KA + Sbjct: 59 IEAGAKIIRANTAEANAYHLSFFKL-EKKLKEIVSSSIGLAKKALGF--------KEGWI 109 Query: 119 AGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 AG++ P AD + + + ++ LL+ G DLL ET + S++ Sbjct: 110 AGTINPIWVRPADPP-------IDLSTRRTLYEEQISLLLEEGCDLLFFETFTDLSDLLL 162 Query: 179 LAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGIN-CIALENTTA 237 EL + + LS G L++ + L ++ +GIN ++ + Sbjct: 163 GLELARNKGAQFLFAFVASFEEGKLSSGQSLKEAFSKLREAGALL-VGINGASGVQASLH 221 Query: 238 ALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCR 297 L+ + L YPN+G+ K + + + ++ G L+GG Sbjct: 222 LLEEIEKKETDLLGAYPNAGKPEFYEGKL--TYSASPSYFGQNVLKFVEEGLNLLGGDYG 279 Query: 298 TTPADIAALK 307 T P +AA+ Sbjct: 280 TEPVHVAAMA 289 >UniRef50_Q93088 Betaine--homocysteine S-methyltransferase 1 n=79 Tax=Metazoa RepID=BHMT1_HUMAN Length = 406 Score = 178 bits (453), Expect = 2e-43, Method: Composition-based stats. Identities = 67/322 (20%), Positives = 116/322 (36%), Gaps = 40/322 (12%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 + L+ +I++ DG LE RG A W+ + VE+PE +R++H ++ RAG+ Sbjct: 13 ILERLNAGEIVIGDGGFVFALEKRGYVKAGP-WTPEAAVEHPEAVRQLHREFLRAGSNVM 71 Query: 67 ITASYQATPAGFAARG---LDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVG 123 T ++ A+ RG L++ + + + ++AR+ + G LVAG V Sbjct: 72 QTFTFYASEDKLENRGNYVLEKISGQEVNEAACDIARQVADE--------GDALVAGGVS 123 Query: 124 PYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 +YL+ SE + ++E + D L E + E E L Sbjct: 124 QTPSYLSCKSET---------EVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVETL 174 Query: 184 TAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHL 242 A + + L G P + L + +G+NC + ++ + Sbjct: 175 IA-SGKPVAATMCIGPEGDL-HGVPPGECAVRLVKAGASI-IGVNCHFDPTISLKTVKLM 231 Query: 243 H-----GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLA----------DYLPQWQAA 287 L+ P + D + + E L Y + Sbjct: 232 KEGLEAARLKAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNL 291 Query: 288 GARLIGGCCRTTPADIAALKAR 309 G R IGGCC P I A+ Sbjct: 292 GVRYIGGCCGFEPYHIRAIAEE 313 >UniRef50_A4EBI1 Putative uncharacterized protein n=1 Tax=Collinsella aerofaciens ATCC 25986 RepID=A4EBI1_9ACTN Length = 297 Score = 176 bits (448), Expect = 6e-43, Method: Composition-based stats. Identities = 70/287 (24%), Positives = 116/287 (40%), Gaps = 29/287 (10%) Query: 15 DILLLDGAMATEL--EARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 + LL G M + L E ++ + W + P+ + +H Y AGAQ IT ++Q Sbjct: 21 ETLLAQGPMGSVLLSEYDAADIPPAFW----NLAEPQTVSRIHRLYVAAGAQVLITNTFQ 76 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A+ + + + + +V+ AR+A L+ GS+GP G Sbjct: 77 ASSYALKHDQIAPSVA-EVNRGAVDDARQA-----------HPQLLLGSMGPIGI----- 119 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE-ALAELLTAYPRARA 191 E+ + + R + ALL+AG D L ET+ + ++ LA A Sbjct: 120 -EWFAEDSVEYREIRGIAREQAHALLNAGVDGLLIETVTSIRNLQPMLAGARDAADGMPV 178 Query: 192 WFSFTLRDSEHLS-DGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPL 250 SF + D L DG + V + ++G+NC +L AA+ + P+ Sbjct: 179 LVSFVVDDKGDLLGDGLNIEAAVLYAEKH-GANSVGVNCCSLAAANAAVPRMVASATTPV 237 Query: 251 VVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCR 297 V PN G+ H E+ A +W+ AGA ++G CC Sbjct: 238 TVRPNVGDPVQTQDGPVWH--ENPEAFARACIEWRHAGAAMVGSCCG 282 >UniRef50_Q4PDM6 Putative uncharacterized protein n=1 Tax=Ustilago maydis RepID=Q4PDM6_USTMA Length = 448 Score = 176 bits (446), Expect = 9e-43, Method: Composition-based stats. Identities = 105/437 (24%), Positives = 152/437 (34%), Gaps = 137/437 (31%) Query: 6 PLRALLDKQDILLLDGAMATELEARGCNL---ADSLWSAKVLVENPELIRE--------- 53 L +LL I +LDG +AT LE G + LWSA++L E + + + Sbjct: 9 ALESLLSPARIGILDGGLATYLED-GLDFDLSKGPLWSARLLDEKEDDVSDGKGQKGIFD 67 Query: 54 VHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQA 113 HL Y +AGA TA+YQA+ FA D+ + L+ K+V+LA A A+ N + Sbjct: 68 AHLHYLQAGAGIIGTATYQASLESFARANYDQVSASHLMSKAVDLACDALHAHNISNNKV 127 Query: 114 GTLLVA-------GSVGPYGAYLADGSEYRGDY--------------HCSVEAFQAFHRP 152 G A S+GPYGA L++G+EY GDY S+E AFH+ Sbjct: 128 GVASAASARPLLSLSLGPYGAMLSNGAEYTGDYRRTFLAESDPLREQQPSLEEMMAFHQR 187 Query: 153 RVEALLD----AGADLLACETLPNFSEIEALAELL-----------TAYPRARAWFSFTL 197 R+EA + +LA ET+P E A L R + S Sbjct: 188 RIEAFIAQPSWEHVGVLAVETVPRADEALAFRMALENVARSLEQQGRPLERKPVYISMAF 247 Query: 198 RDSEHLSD--------------------------------GTPLRDVVALLAGYP----- 220 D L + +V ++ Sbjct: 248 PDDRRLPWPPVKKSSAAGQEGDVDMDEDNDEDEVEDEEAIQEEMNWLVQIVTDTQVQGQD 307 Query: 221 ---QVVALGINCIALENTTAALQHL---------------------HGLTVLP---LVVY 253 + +GINC ++ + G LP L +Y Sbjct: 308 SLWPISGIGINCTKPYLLPKLVERMSASLVTLNLPASEGGMDLESRRGALGLPKPLLFLY 367 Query: 254 PNSGEHYDAVSKTW---------HHHGEHCAQLADYLPQWQAA--------------GAR 290 P+ G YDAV K W H A A L + + G Sbjct: 368 PDGGLVYDAVRKIWLTPSNAGDLGHGDNSAASWASNLMKLAKSITAGSDAKLPDVWRGV- 426 Query: 291 LIGGCCRTTPADIAALK 307 +GGCC++ +I AL Sbjct: 427 FVGGCCKSGTDEIRALC 443 >UniRef50_B6BST6 Homocysteine S-methyltransferase n=4 Tax=root RepID=B6BST6_9RICK Length = 305 Score = 172 bits (437), Expect = 1e-41, Method: Composition-based stats. Identities = 66/315 (20%), Positives = 122/315 (38%), Gaps = 38/315 (12%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVEN--PELIREVHLDYYRAGAQCAITASY 71 + + +LDG M EL A+G +LWSA +E L+ ++HL Y +GA IT ++ Sbjct: 7 KQVRILDGGMGQELHAKGLISMGTLWSASANLEKKFHNLVVDLHLSYIHSGADVIITNTF 66 Query: 72 QATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLAD 131 A ++E K + ++ LA KA++ +L+AGS+ + Sbjct: 67 SARRIRLIQNKVNEH-FKYINEQACLLAIKAKDL------SKKNVLIAGSLP------SQ 113 Query: 132 GSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARA 191 Y D S E + F +++ D + L + E++ +A + A + Sbjct: 114 SDTYVEDQRNSNEIEKDFLDQ--ATIINPYIDFFYLDVLSSGKELD-IASNVAAKLKKPI 170 Query: 192 WFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLV 251 L+ + L G + +VV + +G C++ E +++ L + LP Sbjct: 171 LAGVHLKKNCLLPSGEAITEVVQKYKNENWLGLIGA-CVSPEIVEKSIEELKEI-NLPFG 228 Query: 252 VYPNSGEHYDAVSKT------------------WHHHGEHCAQLADYLPQWQAAGARLIG 293 N E + + ++ + + GA ++G Sbjct: 229 FKANLWEIEEPGPQRTFNTAKYDEIGTNPNIAFGKRDKYDPKLFYEFSEKIKEKGATILG 288 Query: 294 GCCRTTPADIAALKA 308 GCC TTP+ I A+ Sbjct: 289 GCCETTPSHIEAIAK 303 >UniRef50_A6G2A6 Homocysteine S-methyltransferase, putative n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6G2A6_9DELT Length = 322 Score = 172 bits (436), Expect = 2e-41, Method: Composition-based stats. Identities = 95/308 (30%), Positives = 127/308 (41%), Gaps = 26/308 (8%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 LLLDGA+ATEL RG L L++A+ L+E P+L+ E+H DY AGAQ T S+ Sbjct: 7 PLLLDGALATELRRRGFELEAPLFAARALLEAPDLLVEIHRDYALAGAQVLSTNSFGLHA 66 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 A A G+ E Q+ L +SVEL AR+ + + A Sbjct: 67 ATLARAGMAERQA-ELAARSVELTFLARQLVRQSGSERTSFR--------VAASVPPPPP 117 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 + E +A R AL+DAGADL+ ET I A E+ A W S Sbjct: 118 SPSEGDAPELTRAALRSLASALVDAGADLVLFETFAKPEHIRAALEVAGAL-EVPVWLSV 176 Query: 196 TLRD----SEHLSDGTPLRDVVALLA--GYPQVVALGINCIALENTTAALQHL------H 243 L G P + ALL G + AL +NC ++ AL L Sbjct: 177 VGDARPGHRGQLLGGVPFDALAALLREPGLRRPDALLLNCTQIDAVPRALDALLQTARAA 236 Query: 244 GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAA--GARLIGGCCRTTPA 301 GL + L +YP+ G W A + W AA + G CC +TPA Sbjct: 237 GLEGVDLGLYPHLGRARH--DGEWIDRILEAEVYAGQIEAWMAARPALSIAGACCGSTPA 294 Query: 302 DIAALKAR 309 + AL R Sbjct: 295 YVEALARR 302 >UniRef50_D0NMR8 Putative uncharacterized protein n=1 Tax=Phytophthora infestans T30-4 RepID=D0NMR8_PHYIN Length = 305 Score = 171 bits (434), Expect = 2e-41, Method: Composition-based stats. Identities = 68/314 (21%), Positives = 106/314 (33%), Gaps = 48/314 (15%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLV--ENPELIREVHLDYYRAGAQCAITASYQA 73 + LLDG EL ARG +WSA LV ++ +L+REVH + A A +Y Sbjct: 11 VTLLDGGTGEELFARGLPDDRFIWSATALVHEQHHKLLREVHTSFLDANADYITCNNYGV 70 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 TP G + + + +AR A + + P + + GS+ P Sbjct: 71 TPGV----GFRDEEIVRYTAVAGRVARDACDRWTKTYPTSPKPKICGSLPPL------LE 120 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWF 193 YR D E + L D ETL + E + + Sbjct: 121 SYRADKVPEHEEGVRLYAMIARTL-KPFVDCYLAETLSSTQEAKMALLGVQQAKENVCKV 179 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTV------ 247 + + + GT ++ A+ NC E+ AL+ LH Sbjct: 180 ---VENVLSFTAGTS----------RTELQAILFNCSQPEDICKALKELHDDDNTQASLR 226 Query: 248 ---LPLVVYPNSGEHYDAVSKTW----------HHHGEHCAQLADYLPQWQAAGARLIGG 294 + L Y N + W + D++ QW GA ++GG Sbjct: 227 SRGVRLGAYAN---RLTVIPDDWALAESSEPQAMRKDLAVERYRDFVSQWVELGADVVGG 283 Query: 295 CCRTTPADIAALKA 308 CC P IA++ Sbjct: 284 CCGIGPEYIASIHD 297 >UniRef50_Q4GZ92 Homocysteine S-methyltransferase, putative n=2 Tax=Trypanosoma brucei RepID=Q4GZ92_9TRYP Length = 433 Score = 166 bits (422), Expect = 6e-40, Method: Composition-based stats. Identities = 88/413 (21%), Positives = 141/413 (34%), Gaps = 121/413 (29%) Query: 14 QDILLLDGAMATELEARGCNLAD--SLWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 Q +DGA+ T +E G + + S+WS L+ + E++R VH Y GA +T +Y Sbjct: 22 QHFFTMDGAVGTLVERCGLDPSKMGSMWSTSALITDEEIVRYVHKSYLDVGADVILTNTY 81 Query: 72 QATPAGFAARGLDEAQSKALIGKSVEL---------ARKAREAYL--------------- 107 Q AG A G+ + ++ +V + A +EA + Sbjct: 82 QMHAAGCAQAGVTMNE---VVNTAVRVLCDGITPERAAATKEAKVWAQHVMNNKRSEFVN 138 Query: 108 ---------AENPQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALL 158 ++ +LV GS+G YGA L + EYRG+Y + + + ++ R A + Sbjct: 139 VFAPLFYGPRDDASKCPVLVGGSLGSYGASLGNAQEYRGEYEVNEDIIRDYYVGRFMAFV 198 Query: 159 DA--------GADLLACETLPNFSEIEALAELLT------AYPRARAWFSF--------- 195 + D + ET+P +E + L A SF Sbjct: 199 NHVDEKEAHLKVDFIMIETIPLLNEAIEIFTWLKYQKEDETLRSAPVCLSFISCLREPRP 258 Query: 196 --TLRDSE------------HLSDGTPLRDVVALLA--GYPQVVALGINCIALENTTAAL 239 T+ D+ L DG L PQ+V G NC + + Sbjct: 259 DVTVDDATLNEWWLAAESNIRLIDGNTFEKAFNSLMELQLPQLVGFGTNCCSPLEASVVA 318 Query: 240 QHL-----HGLTV--LPLVVYPNSGEHY-----------DAVSKTWHHHGEHCAQLADYL 281 H +T L L +Y NSGE++ S + + Sbjct: 319 SAFLKKKKHKVTDPSLALFLYSNSGENFKEGEWHWGGQLPRGSHSPTSSPKETLPFTTLQ 378 Query: 282 PQWQ--AAGAR------------------------LIGGCCRTTPADIAALKA 308 A R + GGCCR+TP DIA +++ Sbjct: 379 RLMLCCEADVRTAAFFAYQLLLQRPEADDWLFDIIICGGCCRSTPEDIAMIRS 431 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_Q47690 Homocysteine S-methyltransferase n=56 Tax=Bacter... 368 e-100 UniRef50_O31463 Homocysteine S-methyltransferase ybgG n=13 Tax=B... 332 1e-89 UniRef50_Q1WRK4 Homocysteine S-methyltransferase n=10 Tax=Lactob... 329 7e-89 UniRef50_B0K7W0 Homocysteine S-methyltransferase n=13 Tax=Firmic... 311 2e-83 UniRef50_C4V3M8 Homocysteine S-methyltransferase n=5 Tax=Bacteri... 311 3e-83 UniRef50_C6VP70 Homocysteine methyltransferase n=7 Tax=Bacteria ... 311 3e-83 UniRef50_Q8LAX0 Homocysteine S-methyltransferase 3 n=52 Tax=Embr... 308 1e-82 UniRef50_Q2LWJ5 5-methyltetrahydrofolate--homocysteine methyltra... 307 2e-82 UniRef50_A4J6L9 Methionine synthase (B12-dependent) n=1 Tax=Desu... 305 2e-81 UniRef50_D1BKY6 Homocysteine S-methyltransferase n=3 Tax=Veillon... 304 2e-81 UniRef50_Q0BQM8 Homocysteine S-methyltransferase n=1 Tax=Granuli... 304 3e-81 UniRef50_B3S7K9 Putative uncharacterized protein n=1 Tax=Trichop... 302 1e-80 UniRef50_D1HYS9 Whole genome shotgun sequence of line PN40024, s... 302 1e-80 UniRef50_D2RKX3 Homocysteine S-methyltransferase n=2 Tax=Acidami... 301 2e-80 UniRef50_B9L045 Methylenetetrahydrofolate reductase n=1 Tax=Ther... 300 5e-80 UniRef50_C1F5Y3 Homocysteine S-methyltransferase n=1 Tax=Acidoba... 299 6e-80 UniRef50_C9KQD5 Vitamin B12-dependent methionine synthase family... 299 7e-80 UniRef50_B2VXK3 Homocysteine S-methyltransferase n=2 Tax=Pleospo... 299 7e-80 UniRef50_B9E9X6 Putative uncharacterized protein n=1 Tax=Macroco... 299 8e-80 UniRef50_A5VKC8 Homocysteine S-methyltransferase n=10 Tax=Lactob... 297 2e-79 UniRef50_B0NWZ7 Putative uncharacterized protein n=1 Tax=Clostri... 296 8e-79 UniRef50_B1MXY2 Homocysteine S-methyltransferase n=1 Tax=Leucono... 295 1e-78 UniRef50_A4XIN5 Methylenetetrahydrofolate reductase n=1 Tax=Cald... 294 2e-78 UniRef50_B8CZI7 Homocysteine S-methyltransferase n=1 Tax=Halothe... 294 2e-78 UniRef50_Q2JJL4 Methionine synthase n=30 Tax=Bacteria RepID=Q2JJ... 294 3e-78 UniRef50_A8YVC8 Homocysteine S-methyltransferase n=2 Tax=Lactoba... 293 6e-78 UniRef50_C3ZEE1 Putative uncharacterized protein n=1 Tax=Branchi... 292 9e-78 UniRef50_Q4S116 Chromosome 1 SCAF14770, whole genome shotgun seq... 292 1e-77 UniRef50_A0Q0N0 5-methyltetrahydrofolate--homocysteine methyltra... 291 2e-77 UniRef50_C8W2L3 Homocysteine S-methyltransferase n=1 Tax=Desulfo... 291 3e-77 UniRef50_A8KB71 Zgc:171603 protein n=4 Tax=Clupeocephala RepID=A... 290 4e-77 UniRef50_B9MN09 Methylenetetrahydrofolate reductase n=2 Tax=root... 290 5e-77 UniRef50_B0RCV4 Homocysteine s-methyltransferase n=15 Tax=Actino... 289 6e-77 UniRef50_A6TTI3 Homocysteine S-methyltransferase n=6 Tax=Firmicu... 289 8e-77 UniRef50_Q5M5A7 Homocysteine S-methyltransferase (S-methylmethio... 289 1e-76 UniRef50_Q4Q0C9 Homocysteine S-methyltransferase, putative n=3 T... 289 1e-76 UniRef50_C3WBE7 Methionine synthase n=1 Tax=Fusobacterium mortif... 288 2e-76 UniRef50_Q0AX05 Methionine synthase (B12-dependent) n=1 Tax=Synt... 287 4e-76 UniRef50_D1CBD0 Methylenetetrahydrofolate reductase n=1 Tax=Ther... 286 5e-76 UniRef50_D1BQ67 Homocysteine S-methyltransferase n=4 Tax=Veillon... 286 5e-76 UniRef50_Q99707 Methionine synthase n=289 Tax=cellular organisms... 286 9e-76 UniRef50_B4DST3 cDNA FLJ56487, highly similar to Methionine synt... 286 9e-76 UniRef50_B7ZLW7 MTR protein n=1 Tax=Homo sapiens RepID=B7ZLW7_HUMAN 286 1e-75 UniRef50_A9B657 Methylenetetrahydrofolate reductase n=1 Tax=Herp... 284 3e-75 UniRef50_A5IKF3 Methionine synthase (B12-dependent) n=6 Tax=Ther... 284 3e-75 UniRef50_C1F3L2 Methylenetetrahydrofolate reductase n=2 Tax=Bact... 284 3e-75 UniRef50_Q5PNQ3 Novel protein containing a homocysteine S-methyl... 284 4e-75 UniRef50_A4XIN4 Homocysteine S-methyltransferase n=1 Tax=Caldice... 283 4e-75 UniRef50_C6JIG3 Methionine synthase n=3 Tax=Fusobacterium RepID=... 283 4e-75 UniRef50_A3ERA3 5-methyltetrahydrofolate--homocysteine methyltra... 283 6e-75 UniRef50_C1XT53 Methionine synthase (B12-dependent) n=2 Tax=Meio... 283 6e-75 UniRef50_C0ZBM1 5-methyltetrahydrofolate--homocysteine methyltra... 283 7e-75 UniRef50_Q5E814 Methionine synthase n=458 Tax=Bacteria RepID=MET... 282 1e-74 UniRef50_B8I366 Homocysteine S-methyltransferase n=1 Tax=Clostri... 282 1e-74 UniRef50_A9B073 Methionine synthase n=2 Tax=Bacteria RepID=A9B07... 282 1e-74 UniRef50_UPI00017B4C9F UPI00017B4C9F related cluster n=1 Tax=Tet... 281 2e-74 UniRef50_A9KSG0 Homocysteine S-methyltransferase n=7 Tax=Clostri... 280 4e-74 UniRef50_Q01QP4 Methylenetetrahydrofolate reductase n=2 Tax=Acid... 280 5e-74 UniRef50_B6YR37 Cobalamin-dependent methionine synthase n=1 Tax=... 280 5e-74 UniRef50_B9MN08 Homocysteine S-methyltransferase n=1 Tax=Anaeroc... 280 5e-74 UniRef50_B3E428 Methionine synthase n=91 Tax=Bacteria RepID=B3E4... 280 6e-74 UniRef50_C6HW85 5-methyltetrahydrofolate--homocysteine methyltra... 279 7e-74 UniRef50_C0QRY9 Methionine synthase n=3 Tax=Bacteria RepID=C0QRY... 279 8e-74 UniRef50_Q1GBT8 Homocysteine S-methyltransferase n=2 Tax=Lactoba... 279 9e-74 UniRef50_C6W4B8 Methionine synthase n=4 Tax=Bacteria RepID=C6W4B... 279 1e-73 UniRef50_Q67LG1 5-methyltetrahydrofolate S-homocysteine methyltr... 279 1e-73 UniRef50_B3QGP3 Methionine synthase n=71 Tax=cellular organisms ... 279 1e-73 UniRef50_UPI0000DB6B54 PREDICTED: similar to CG10621-PA n=3 Tax=... 279 1e-73 UniRef50_C6DY72 Homocysteine S-methyltransferase n=10 Tax=Desulf... 278 1e-73 UniRef50_B5YB64 5-methyltetrahydrofolate-homocysteine methyltran... 278 1e-73 UniRef50_Q7M929 S-METHYLTRANSFERASE n=1 Tax=Wolinella succinogen... 277 2e-73 UniRef50_Q2F5Q8 Homocysteine S-methyltransferase n=3 Tax=Endopte... 277 3e-73 UniRef50_Q01YW7 Methionine synthase (B12-dependent) n=5 Tax=Bact... 277 4e-73 UniRef50_B8FX16 Homocysteine S-methyltransferase n=2 Tax=Desulfi... 277 4e-73 UniRef50_B6GAW1 Putative uncharacterized protein n=1 Tax=Collins... 276 5e-73 UniRef50_A6G853 Homocysteine methyltransferase n=3 Tax=Bacteria ... 276 6e-73 UniRef50_Q5SKM5 5-methyltetrahydrofolate homocysteine S-methyltr... 276 1e-72 UniRef50_C7NB07 Methionine synthase n=6 Tax=Leptotrichia RepID=C... 275 1e-72 UniRef50_C6D4G9 Methylenetetrahydrofolate reductase n=12 Tax=cel... 275 1e-72 UniRef50_UPI000050FD2A homocysteine methyltransferase n=1 Tax=Br... 273 4e-72 UniRef50_C4R8J7 S-adenosylmethionine-homocysteine methyltransfer... 273 5e-72 UniRef50_B9XKW8 Methylenetetrahydrofolate reductase n=1 Tax=bact... 273 5e-72 UniRef50_A9A1I5 Homocysteine S-methyltransferase n=2 Tax=Thaumar... 273 6e-72 UniRef50_UPI0001BC43AA B12-dependent methionine synthase n=1 Tax... 273 7e-72 UniRef50_Q146H9 Methionine synthase (B12-dependent) n=21 Tax=cel... 273 7e-72 UniRef50_D0MU48 Methionine synthase n=1 Tax=Phytophthora infesta... 272 1e-71 UniRef50_C4LIL8 5-methyltetrahydrofolate--homocysteinemethyltran... 272 1e-71 UniRef50_A6LKZ2 Homocysteine S-methyltransferase n=6 Tax=Bacteri... 271 2e-71 UniRef50_A8SP62 Putative uncharacterized protein n=2 Tax=Clostri... 271 3e-71 UniRef50_O06745 5,10-methylenetetrahydrofolate reductase n=78 Ta... 270 4e-71 UniRef50_B8DYM9 Homocysteine S-methyltransferase n=1 Tax=Dictyog... 270 4e-71 UniRef50_C1SMZ8 5-methyltetrahydrofolate--homocysteine methyltra... 269 9e-71 UniRef50_UPI0001C311AB homocysteine S-methyltransferase n=1 Tax=... 269 9e-71 UniRef50_C8X6V8 Homocysteine S-methyltransferase n=14 Tax=Actino... 269 9e-71 UniRef50_UPI00016C59CA 5-methyltetrahydrofolate--homocysteine S-... 269 1e-70 UniRef50_C3XLV5 S-methyltransferase n=2 Tax=Helicobacter RepID=C... 267 3e-70 UniRef50_A6QBA6 5-methyltetrahydrofolate--homocysteine methyltra... 266 1e-69 UniRef50_Q6AL45 Related to 5-methyltetrahydrofolate--homocystein... 266 1e-69 UniRef50_C3RK90 Homocysteine S-methyltransferase n=3 Tax=Bacteri... 266 1e-69 UniRef50_C7JFY7 Methionine synthase n=8 Tax=Acetobacter pasteuri... 266 1e-69 UniRef50_D2UDY2 Probable 5-methyltetrahydrofolate-homocysteine m... 264 2e-69 UniRef50_C0QY88 5-methyltetrahydrofolate--homocysteine methyltra... 264 3e-69 UniRef50_C9RQ92 Methionine synthase n=1 Tax=Fibrobacter succinog... 264 3e-69 UniRef50_A5TSW8 Methionine synthase n=9 Tax=Fusobacterium RepID=... 264 4e-69 UniRef50_A7SKT1 Predicted protein n=4 Tax=Eumetazoa RepID=A7SKT1... 264 4e-69 UniRef50_A0APQ1 CG10623 protein n=22 Tax=Drosophila RepID=A0APQ1... 263 5e-69 UniRef50_C1EAX2 Predicted protein n=36 Tax=cellular organisms Re... 263 7e-69 UniRef50_C5D740 Methionine synthase n=8 Tax=Bacteria RepID=C5D74... 262 9e-69 UniRef50_B9W8L8 Homocysteine S-methyltransferase, putative (S-me... 262 1e-68 UniRef50_Q49V93 Putative homocysteine S-methyltransferase n=1 Ta... 262 1e-68 UniRef50_Q5N5P4 5-methyltetrahydrofolate--homocysteine methyltra... 262 1e-68 UniRef50_B2UNQ8 Methionine synthase n=1 Tax=Akkermansia muciniph... 261 2e-68 UniRef50_Q9VJ32 CG10621 n=19 Tax=Neoptera RepID=Q9VJ32_DROME 261 2e-68 UniRef50_A9FZY9 Methylenetetrahydrofolate reductase n=1 Tax=Sora... 261 2e-68 UniRef50_B0TAJ7 Methionine synthase, putative n=1 Tax=Heliobacte... 261 2e-68 UniRef50_A7VWF8 Putative uncharacterized protein n=1 Tax=Clostri... 260 3e-68 UniRef50_Q49775 Methionine synthase n=41 Tax=Bacteria RepID=METH... 260 4e-68 UniRef50_B7GLS5 Methionine synthase I containing methyltransfera... 260 5e-68 UniRef50_UPI000196BD90 hypothetical protein CATMIT_02259 n=1 Tax... 259 1e-67 UniRef50_D2RMA2 Homocysteine S-methyltransferase n=13 Tax=Bacter... 258 2e-67 UniRef50_A1AKP7 Methylenetetrahydrofolate reductase n=10 Tax=Des... 258 2e-67 UniRef50_D1Y627 Homocysteine S-methyltransferase n=1 Tax=Pyramid... 258 2e-67 UniRef50_A5UPF4 Methionine synthase (B12-dependent) n=5 Tax=Chlo... 257 3e-67 UniRef50_C4GEB2 Putative uncharacterized protein n=1 Tax=Shuttle... 257 3e-67 UniRef50_Q5ZBZ6 Os01g0772900 protein n=3 Tax=Magnoliophyta RepID... 257 3e-67 UniRef50_B8J7W9 Methionine synthase n=3 Tax=Anaeromyxobacter Rep... 257 4e-67 UniRef50_Q55786 Methionine synthase n=14 Tax=Cyanobacteria RepID... 257 4e-67 UniRef50_Q2LQ11 Methylenetetrahydrofolate reductase n=1 Tax=Synt... 256 6e-67 UniRef50_Q1IQK2 Methionine synthase (B12-dependent) n=40 Tax=cel... 255 1e-66 UniRef50_C0QE32 Methionine synthase I, cobalamin-binding domain ... 254 2e-66 UniRef50_Q30ZI4 Methionine synthase (B12-dependent) n=14 Tax=Des... 254 3e-66 UniRef50_A9FAG8 Methionine synthase n=91 Tax=Bacteria RepID=A9FA... 253 5e-66 UniRef50_A8Q150 Probable homocysteine S-methyltransferase, putat... 252 1e-65 UniRef50_C4XYV2 Putative uncharacterized protein n=1 Tax=Clavisp... 252 1e-65 UniRef50_A5ZUF2 Putative uncharacterized protein n=2 Tax=Clostri... 251 2e-65 UniRef50_C7N1R7 Methionine synthase (B12-dependent) n=5 Tax=Bact... 251 3e-65 UniRef50_Q024B4 Homocysteine S-methyltransferase n=2 Tax=Bacteri... 250 4e-65 UniRef50_Q1NSQ8 Methylenetetrahydrofolate reductase n=3 Tax=Delt... 250 5e-65 UniRef50_Q8DUN2 Methylenetetrahydrofolate reductase n=12 Tax=Str... 249 7e-65 UniRef50_C5MAR2 Putative uncharacterized protein n=1 Tax=Candida... 249 9e-65 UniRef50_B2A781 Homocysteine S-methyltransferase n=1 Tax=Natrana... 248 2e-64 UniRef50_UPI000180BE5F PREDICTED: similar to CG10623 CG10623-PA ... 248 2e-64 UniRef50_B9DIA5 Methylenetetrahydrofolate reductase n=10 Tax=Sta... 247 2e-64 UniRef50_C0D4W7 Putative uncharacterized protein n=3 Tax=Clostri... 247 3e-64 UniRef50_C6LEJ3 Vitamin B12-dependent methionine synthase family... 247 3e-64 UniRef50_D0NSW2 Homocysteine S-methyltransferase, putative n=1 T... 247 3e-64 UniRef50_Q6BZK6 DEHA2A00616p n=1 Tax=Debaryomyces hansenii RepID... 247 3e-64 UniRef50_D1B7X8 Homocysteine S-methyltransferase n=1 Tax=Therman... 246 7e-64 UniRef50_C6VPC5 Methylenetetrahydrofolate reductase n=3 Tax=Lact... 245 2e-63 UniRef50_D2PQB9 Methionine synthase n=2 Tax=Actinomycetales RepI... 244 3e-63 UniRef50_A8SPV0 Methylenetetrahydrofolate reductase n=2 Tax=Clos... 244 5e-63 UniRef50_B1H0N5 Homocysteine S-methyltransferase n=1 Tax=uncultu... 243 5e-63 UniRef50_C7LX76 Methylenetetrahydrofolate reductase n=1 Tax=Desu... 242 1e-62 UniRef50_A3TGH3 Homocysteine methyltransferase n=1 Tax=Janibacte... 242 1e-62 UniRef50_C3YH00 Putative uncharacterized protein n=1 Tax=Branchi... 242 1e-62 UniRef50_A6DGP4 5-methyltetrahydrofolate--homocysteine methyltra... 241 2e-62 UniRef50_A5DCB0 Putative uncharacterized protein n=2 Tax=Pichia ... 241 3e-62 UniRef50_Q15S12 Homocysteine S-methyltransferase n=1 Tax=Pseudoa... 239 7e-62 UniRef50_C9M596 Vitamin B12-dependent methionine synthase family... 239 8e-62 UniRef50_C4QA25 Putative uncharacterized protein n=1 Tax=Schisto... 237 3e-61 UniRef50_C3PEG0 Homocysteine S-methyltransferase n=3 Tax=Coryneb... 237 3e-61 UniRef50_UPI0001AEC485 homocysteine S-methyltransferase family p... 237 6e-61 UniRef50_C8WWX3 Methylenetetrahydrofolate reductase n=2 Tax=Alic... 236 6e-61 UniRef50_A1SWN6 Homocysteine S-methyltransferase n=1 Tax=Psychro... 234 3e-60 UniRef50_D0LSQ2 Methylenetetrahydrofolate reductase n=1 Tax=Hali... 234 4e-60 UniRef50_B7AQD9 Methylenetetrahydrofolate reductase n=1 Tax=Bact... 233 6e-60 UniRef50_Q1AXR8 Methylenetetrahydrofolate reductase n=2 Tax=Bact... 233 6e-60 UniRef50_B1HTR8 Methylenetetrahydrofolate reductase n=95 Tax=Bac... 232 1e-59 UniRef50_A4WQF1 Homocysteine S-methyltransferase n=39 Tax=Alphap... 232 2e-59 UniRef50_UPI0001BC6543 5-methyltetrahydrofolate--homocysteine me... 231 3e-59 UniRef50_A7TSR2 Putative uncharacterized protein n=1 Tax=Vanderw... 231 3e-59 UniRef50_Q0SIE4 Methionine synthase n=23 Tax=Bacteria RepID=Q0SI... 231 3e-59 UniRef50_C3MDS4 Homocysteine S-methyltransferase, putative n=12 ... 230 4e-59 UniRef50_B0PG09 Putative uncharacterized protein n=1 Tax=Anaerot... 230 5e-59 UniRef50_D1N227 Methylenetetrahydrofolate reductase n=1 Tax=Vict... 230 6e-59 UniRef50_Q0TQI2 Homocysteine S-methyltransferase family protein ... 230 6e-59 UniRef50_C1C2Y0 Homocysteine S-methyltransferase 1 n=1 Tax=Calig... 230 7e-59 UniRef50_D2R929 Homocysteine S-methyltransferase n=1 Tax=Pirellu... 229 9e-59 UniRef50_B4RRL7 Homocysteine S-methyltransferase family protein ... 229 1e-58 UniRef50_Q2S678 Vitamin B12-dependent methionine synthase family... 227 3e-58 UniRef50_C4Z117 Methylenetetrahydrofolate reductase n=1 Tax=Euba... 227 4e-58 UniRef50_Q08985 Homocysteine S-methyltransferase 2 n=17 Tax=Sacc... 227 5e-58 UniRef50_Q2RU64 Methionine synthase (B12-dependent) n=10 Tax=cel... 226 7e-58 UniRef50_B5JEM8 Homocysteine S-methyltransferase, putative n=1 T... 226 8e-58 UniRef50_A8TIL6 Methionine synthase I n=3 Tax=Proteobacteria Rep... 225 1e-57 UniRef50_Q6C0D6 YALI0F25641p n=1 Tax=Yarrowia lipolytica RepID=Q... 224 3e-57 UniRef50_D1BTI0 Methionine synthase n=24 Tax=Actinomycetales Rep... 223 6e-57 UniRef50_A4EKV4 Methionine synthase I n=4 Tax=Alphaproteobacteri... 222 1e-56 UniRef50_Q753B4 AFR410Wp n=1 Tax=Eremothecium gossypii RepID=Q75... 222 1e-56 UniRef50_A5DTG6 Putative uncharacterized protein n=1 Tax=Loddero... 221 3e-56 UniRef50_B7I892 Homocysteine S-methyltransferase family protein ... 221 3e-56 UniRef50_C5E3E4 KLTH0H12716p n=1 Tax=Lachancea thermotolerans CB... 220 4e-56 UniRef50_A8M0Q1 Homocysteine S-methyltransferase n=3 Tax=Actinom... 220 4e-56 UniRef50_A3LQC9 AdoMet-homocysteine methyltransferase n=1 Tax=Pi... 220 5e-56 UniRef50_A4J5C2 Methylenetetrahydrofolate reductase n=5 Tax=Clos... 220 5e-56 UniRef50_UPI0001BCEC92 bifunctional homocysteine S-methyltransfe... 219 9e-56 UniRef50_A7VPD0 Methylenetetrahydrofolate reductase n=1 Tax=Clos... 219 1e-55 UniRef50_B4DBI1 Homocysteine S-methyltransferase n=1 Tax=Chthoni... 219 2e-55 UniRef50_C6UN88 Putative B12-dependent methionine synthase n=1 T... 217 5e-55 UniRef50_Q28RZ7 Homocysteine S-methyltransferase n=13 Tax=Rhodob... 216 1e-54 UniRef50_A5N923 Methylenetetrahydrofolate reductase n=2 Tax=Clos... 215 1e-54 UniRef50_A1WU24 Homocysteine S-methyltransferase n=7 Tax=Proteob... 214 4e-54 UniRef50_B8M2P0 Homocysteine S-methyltransferase, putative n=1 T... 213 6e-54 UniRef50_B6BT42 Homocysteine S-methyltransferase 4, putative n=1... 213 7e-54 UniRef50_C0ADK0 Homocysteine S-methyltransferase n=1 Tax=Opituta... 213 8e-54 UniRef50_B2AAZ0 Predicted CDS Pa_1_5620 n=2 Tax=Sordariales RepI... 212 1e-53 UniRef50_B7VQ49 Homocysteine S-methyltransferase family protein ... 212 1e-53 UniRef50_A3JFK5 Putative uncharacterized protein n=1 Tax=Marinob... 211 2e-53 UniRef50_B0MM61 Putative uncharacterized protein n=1 Tax=Eubacte... 211 2e-53 UniRef50_B9NLU8 Homocysteine S-methyltransferase family protein ... 211 2e-53 UniRef50_D2S8U0 Homocysteine S-methyltransferase n=12 Tax=Actino... 211 3e-53 UniRef50_B6AUX0 Homocysteine S-methyltransferase n=1 Tax=Rhodoba... 210 3e-53 UniRef50_A8SCX4 Methylenetetrahydrofolate reductase n=3 Tax=Clos... 210 4e-53 UniRef50_C4GEB4 Methylenetetrahydrofolate reductase n=1 Tax=Shut... 209 8e-53 UniRef50_B8I637 Methylenetetrahydrofolate reductase n=2 Tax=Clos... 207 3e-52 UniRef50_C5RGW2 Methylenetetrahydrofolate reductase n=1 Tax=Clos... 207 6e-52 UniRef50_UPI00016C0A13 5-methyltetrahydrofolate--homocysteine me... 205 1e-51 UniRef50_C8VHP4 Homocysteine S-methyltransferase (Eurofung) n=5 ... 205 1e-51 UniRef50_UPI000190A21A homocysteine S-methyltransferase n=2 Tax=... 205 2e-51 UniRef50_A9GUQ7 Putative homocysteine S-methyltransferase family... 205 2e-51 UniRef50_Q65V50 MHT1 protein n=3 Tax=Pasteurellaceae RepID=Q65V5... 205 2e-51 UniRef50_C0EVI7 Methylenetetrahydrofolate reductase n=1 Tax=Euba... 205 2e-51 UniRef50_D1Z559 Whole genome shotgun sequence assembly, scaffold... 204 2e-51 UniRef50_Q93088 Betaine--homocysteine S-methyltransferase 1 n=79... 203 7e-51 UniRef50_B0PF81 Methylenetetrahydrofolate reductase n=1 Tax=Anae... 202 1e-50 UniRef50_A9QPD6 Methylenetetrahydrofolate reductase n=1 Tax=Meth... 202 1e-50 UniRef50_B8PAR1 Predicted protein (Fragment) n=1 Tax=Postia plac... 201 3e-50 UniRef50_B7G6P4 Predicted protein n=2 Tax=cellular organisms Rep... 200 7e-50 UniRef50_B1KCG4 Homocysteine S-methyltransferase n=52 Tax=Proteo... 199 9e-50 UniRef50_A1DJI9 Homocysteine S-methyltransferase, putative n=4 T... 198 3e-49 UniRef50_C9SAQ6 Homocysteine S-methyltransferase n=1 Tax=Vertici... 196 7e-49 UniRef50_B5IJ26 Homocysteine S-methyltransferase n=2 Tax=Bacteri... 196 8e-49 UniRef50_A4EBI1 Putative uncharacterized protein n=1 Tax=Collins... 195 1e-48 UniRef50_D1CH13 Homocysteine S-methyltransferase n=1 Tax=Thermob... 195 1e-48 UniRef50_B1A1E6 Homocysteine methyltransferase (Fragment) n=1 Ta... 195 2e-48 UniRef50_A6S563 Putative uncharacterized protein n=2 Tax=Sclerot... 195 2e-48 UniRef50_P74718 Slr1189 protein n=1 Tax=Synechocystis sp. PCC 68... 194 3e-48 UniRef50_A0Z513 Putative uncharacterized protein n=1 Tax=marine ... 193 7e-48 UniRef50_Q5UEY6 Putative homocysteine S-methyltransferase family... 193 9e-48 UniRef50_A8N5L5 Putative uncharacterized protein n=1 Tax=Coprino... 192 1e-47 UniRef50_Q4FMM0 Homocysteine S-methyltransferase n=2 Tax=Candida... 192 1e-47 UniRef50_Q2G5H0 Homocysteine S-methyltransferase n=6 Tax=Bacteri... 189 8e-47 UniRef50_A2R696 Contig An15c0240, complete genome n=9 Tax=Leotio... 189 1e-46 UniRef50_B7G9Z1 Predicted protein n=1 Tax=Phaeodactylum tricornu... 188 2e-46 UniRef50_B0TW11 Betaine-homocysteine methyltransferase n=10 Tax=... 188 3e-46 UniRef50_Q5KA93 Homocysteine S-methyltransferase, putative n=1 T... 187 4e-46 UniRef50_A6UMQ0 Homocysteine S-methyltransferase n=1 Tax=Sinorhi... 187 4e-46 UniRef50_A3JU33 Homocysteine S-methyltransferase n=3 Tax=Rhodoba... 184 3e-45 UniRef50_C3M8I7 Homocysteine S-methyltransferase n=4 Tax=Bacteri... 183 9e-45 UniRef50_A6U723 Homocysteine S-methyltransferase n=11 Tax=Bacter... 182 1e-44 Sequences not found previously or not previously below threshold: >UniRef50_Q47690 Homocysteine S-methyltransferase n=56 Tax=Bacteria RepID=MMUM_ECOLI Length = 310 Score = 368 bits (945), Expect = e-100, Method: Composition-based stats. Identities = 310/310 (100%), Positives = 310/310 (100%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR Sbjct: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG Sbjct: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA Sbjct: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQ 240 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQ Sbjct: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQ 240 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP Sbjct: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 Query: 301 ADIAALKARS 310 ADIAALKARS Sbjct: 301 ADIAALKARS 310 >UniRef50_O31463 Homocysteine S-methyltransferase ybgG n=13 Tax=Bacteria RepID=HMT_BACSU Length = 315 Score = 332 bits (851), Expect = 1e-89, Method: Composition-based stats. Identities = 155/307 (50%), Positives = 208/307 (67%), Gaps = 4/307 (1%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 NP++ +LD +++LDGAMATELE +GCNL DSLWSAK+L+E PELI++VH DY+ AGA Sbjct: 2 NPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEEPELIKQVHTDYFAAGAD 61 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQA---GTLLVAGS 121 CAITASYQ+T GFAARGL EA+++ LI SV +A +AR+ + + ++A S Sbjct: 62 CAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDEFWSLEENRLNRPKPIIAAS 121 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 +GPYGAYLADGSEYRG+Y S + FHRPR++AL++AGAD+LACET+P +E +A+ Sbjct: 122 IGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEAGADVLACETIPCLTEAKAIVR 181 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQH 241 LL +P AW SF+ +D H+SDGTP D + L + Q+ ALGINC L++ + ++ Sbjct: 182 LLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDEHRQIAALGINCTPLQHIPSLIEE 241 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 L T P++VYPNSGE YD +KTW+ W GARLIGGCCRT P Sbjct: 242 LKKNTSKPIIVYPNSGEQYDPETKTWNG-AACAESYGASARTWHEKGARLIGGCCRTKPE 300 Query: 302 DIAALKA 308 +I + A Sbjct: 301 NIQEIAA 307 >UniRef50_Q1WRK4 Homocysteine S-methyltransferase n=10 Tax=Lactobacillus RepID=Q1WRK4_LACS1 Length = 307 Score = 329 bits (844), Expect = 7e-89, Method: Composition-based stats. Identities = 137/303 (45%), Positives = 189/303 (62%), Gaps = 5/303 (1%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 L + +LDGAM+T LE G + + LW+AK L++N EL+ E+H Y+ AGA Sbjct: 3 FTEFLTNHTV-VLDGAMSTPLERLGADTNNDLWTAKALIDNEELVYEIHKMYFEAGADLI 61 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 IT +YQA F G E +++ LI K+V++A+KAR+ Y EN +AG++GPYG Sbjct: 62 ITDTYQANVQAFEKVGYSEKEARNLIKKAVKIAQKARDDY--ENRTGKHNYIAGTIGPYG 119 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL-TA 185 AYLA+GSEYRGDY SVE +Q FH PR+E L++A D+LA ET P E+ A+ ELL Sbjct: 120 AYLANGSEYRGDYELSVEEYQQFHLPRIEELVNAEVDILAIETQPKLDEVLAILELLKKK 179 Query: 186 YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL 245 YP+ + + S+TL D + +SDGTPL + L Y QV+A+GINC+ LE AL+++ + Sbjct: 180 YPQQKVYVSYTLSDDDTISDGTPLPRAIHALEDYSQVIAVGINCVKLELVEPALKNMKEI 239 Query: 246 TVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAA 305 T L+VYPNS YD SKTW + A + +P W AGAR+IGGCC T P +I A Sbjct: 240 TDKHLIVYPNSSAVYDPKSKTWSQ-PKTSATFEELIPNWYEAGARIIGGCCTTGPKEIKA 298 Query: 306 LKA 308 + Sbjct: 299 VAD 301 >UniRef50_B0K7W0 Homocysteine S-methyltransferase n=13 Tax=Firmicutes RepID=B0K7W0_THEP3 Length = 807 Score = 311 bits (797), Expect = 2e-83, Method: Composition-based stats. Identities = 71/307 (23%), Positives = 133/307 (43%), Gaps = 25/307 (8%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 + + L +++ DGAM T+L+ RG + + + +PE++ ++H Y AG Sbjct: 1 MLDIFKEL--SNRVIVFDGAMGTQLQERGLKTGE--CPEYMNITHPEVVFDIHRSYIEAG 56 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 A T ++ A A GL E + ++ ++V++A++A + VA S+ Sbjct: 57 ADVIETNTFGANRIKLAKYGL-ENEVFNIVTQAVKIAKEA----------SKDKPVALSI 105 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G L + + + + V A AGAD++ ET+ + E +A Sbjct: 106 GPIGELLTPYGD------MTFDEAYDVFKEVVIAAERAGADIVLIETMSDMLEAKAAILA 159 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 + + T ++ G+ VV L G + A+G+NC + + ++ Sbjct: 160 AKENSNMKVICTMTFQEDGRTLMGSDPITVVVSLQGL-GLDAIGVNCSTGPDKMVSVVEK 218 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 + ++ +P++ PN+G KT + + A + P GA ++GGCC TTP Sbjct: 219 MSQVSRIPIIAQPNAGMPVIRDGKTV--YDLKPEEFASFFPLLVEKGASIVGGCCGTTPH 276 Query: 302 DIAALKA 308 I +K Sbjct: 277 YIKLVKK 283 >UniRef50_C4V3M8 Homocysteine S-methyltransferase n=5 Tax=Bacteria RepID=C4V3M8_9FIRM Length = 349 Score = 311 bits (796), Expect = 3e-83, Method: Composition-based stats. Identities = 150/306 (49%), Positives = 192/306 (62%), Gaps = 5/306 (1%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 N L L QD+L+LDGA+ATELEARG ++ D LWSAK L E P+L+R++HLDY RAGA Sbjct: 19 NVLEVRLAAQDVLVLDGALATELEARGFSVDDPLWSAKALFERPDLVRDIHLDYLRAGAD 78 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTL-LVAGSVG 123 +ASYQAT GF RG ++ L+ +SV LA++AR Y AE + LVA SVG Sbjct: 79 VLTSASYQATVDGFMQRGFTAEEAAELLRRSVRLAQEARGLYRAERSTGTAVPLVAASVG 138 Query: 124 PYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 PYGAYLADGSEYRGDY +A AFH R+ L A DLLACETLP E A+ L Sbjct: 139 PYGAYLADGSEYRGDYDVEEDALTAFHAQRLRILASAAPDLLACETLPCLHEACAIVRSL 198 Query: 184 TAYP-RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHL 242 A R A+FSF+ RD H+SDGT + + +L P+ A+G+NC A + + ++ + Sbjct: 199 RAEGIRIPAYFSFSCRDGAHISDGTEIAECARVLDAVPEAAAIGVNCTAPQYVSGLIRMI 258 Query: 243 HGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPAD 302 T P+VVYPNSGE+YDA ++ W ++ AAGAR+IGGCCRTTP D Sbjct: 259 RQETDKPIVVYPNSGEYYDAAARVWRG---AAEDFGARSREYAAAGARIIGGCCRTTPHD 315 Query: 303 IAALKA 308 AA+ A Sbjct: 316 TAAIAA 321 >UniRef50_C6VP70 Homocysteine methyltransferase n=7 Tax=Bacteria RepID=C6VP70_LACPJ Length = 309 Score = 311 bits (796), Expect = 3e-83, Method: Composition-based stats. Identities = 135/297 (45%), Positives = 185/297 (62%), Gaps = 7/297 (2%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 + ++ DGAMATELE RG +LWSA ++++P+ I+ VH Y AGA+ T +YQ Sbjct: 9 NRGPVVSDGAMATELEKRGVATNSALWSATAMLDHPDAIQAVHQSYLDAGAKIMTTNTYQ 68 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A F G+ AQ++ LI ++V +A AR+A ++AGS+GPYGAYLADG Sbjct: 69 ANVPAFEQAGIAAAQARQLIQQAVTIAHTARDASHV-----TDAVIAGSIGPYGAYLADG 123 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL-TAYPRARA 191 SEY G Y + A+Q FHR R+ ++ AG D+LA ET+P E++AL +L+ T +P+ Sbjct: 124 SEYTGAYQLTPSAYQDFHRERLALIMAAGVDVLALETMPRLDEVQALVQLITTTWPQQPY 183 Query: 192 WFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLV 251 W SF+++D + L DGT L +A P VVA+G+NC LEN AL L +PL+ Sbjct: 184 WVSFSIKDPQTLCDGTSLAAAAKWVAAQPNVVAVGVNCTTLENIAPALTTLKAAVAVPLI 243 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 VYPNSG+ YD V+KTW Q A ++PQW AAGAR+IGGCCRTTP DIA + Sbjct: 244 VYPNSGDQYDPVTKTWQATHLS-HQFASFVPQWLAAGARIIGGCCRTTPKDIATVAR 299 >UniRef50_Q8LAX0 Homocysteine S-methyltransferase 3 n=52 Tax=Embryophyta RepID=HMT3_ARATH Length = 347 Score = 308 bits (790), Expect = 1e-82, Method: Composition-based stats. Identities = 137/322 (42%), Positives = 183/322 (56%), Gaps = 17/322 (5%) Query: 4 NNPLRALLDK-QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 ++ + L+K ++DG ATEL+ G ++ D LWSAK L+ +P L+ +VHLDY +G Sbjct: 10 SSLMTDFLEKCGGYAVVDGGFATELQRHGADINDPLWSAKCLITSPHLVTKVHLDYLESG 69 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQA--------- 113 A ITASYQAT GF A+GL +++ L+ +SVE+ +ARE + + Sbjct: 70 ANIIITASYQATIQGFVAKGLSVGEAENLLRRSVEITYEAREIFYNRCTKGSWDFAYAGK 129 Query: 114 ---GTLLVAGSVGPYGAYLADGSEYRGDYH--CSVEAFQAFHRPRVEALLDAGADLLACE 168 +LVA SVG YGAYLADGSEY G Y S E + FHR RV+ L +GADL+A E Sbjct: 130 ASRRPILVAASVGSYGAYLADGSEYSGIYGDSVSKETLKDFHRRRVQILAKSGADLIAFE 189 Query: 169 TLPNFSEIEALAELLTAYP-RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGI 227 T+PN E EA A+LL AWFSFT +D + G + + + VVA+GI Sbjct: 190 TIPNKLEAEAYADLLEEEDIDIPAWFSFTSKDGVSVPRGDSVVECAKVADSCKNVVAIGI 249 Query: 228 NCIALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHH-GEHCAQLADYLPQWQA 286 NC A A + L +T P+VVYPNSGE YD ++K W GE Y+ +W+ Sbjct: 250 NCTAPRYIHALIISLRQMTRKPIVVYPNSGEVYDGLNKKWIKSEGESEEDFVSYVSKWRD 309 Query: 287 AGARLIGGCCRTTPADIAALKA 308 AGA L GGCCRTTP I A+ Sbjct: 310 AGASLFGGCCRTTPNTIRAIAK 331 >UniRef50_Q2LWJ5 5-methyltetrahydrofolate--homocysteine methyltransferase n=6 Tax=Bacteria RepID=Q2LWJ5_SYNAS Length = 813 Score = 307 bits (788), Expect = 2e-82, Method: Composition-based stats. Identities = 84/308 (27%), Positives = 128/308 (41%), Gaps = 24/308 (7%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M +R LL K+ IL+LDGA TEL+ RG + +E+PE+I+E+H Y + Sbjct: 1 MKSKETIRRLL-KKKILVLDGATGTELQKRGMP--GGVCPELWCLEHPEIIKEIHRSYRQ 57 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AG+ T ++ A A G E + + LAR A LVAG Sbjct: 58 AGSDIVYTCTFGANRYKLAQYGTRE--VREINRNLARLARHAV---------GPKALVAG 106 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 +GP G ++ + E + + +++ LL+ G DL ET+ + E A Sbjct: 107 DIGPTGHFVEPFGDLP------FEEAVSAFKEQIQGLLEGGVDLFVIETMMDIQEARAAL 160 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAAL 239 + A + T + +GT + L A+G NC E A + Sbjct: 161 IAVKETCPAFTVVTLTYENGGRTLNGTDPATALITLQSL-GADAVGCNCSTGPEAMLAFI 219 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 + + +PL PN+G +T+ A + P + AAG L+GGCC TT Sbjct: 220 EAMKPHATVPLAAKPNAGLPRLEGEETF--FDMDAETFASHGPAFAAAGVNLLGGCCGTT 277 Query: 300 PADIAALK 307 P I AL Sbjct: 278 PDHIQALA 285 >UniRef50_A4J6L9 Methionine synthase (B12-dependent) n=1 Tax=Desulfotomaculum reducens MI-1 RepID=A4J6L9_DESRM Length = 800 Score = 305 bits (781), Expect = 2e-81, Method: Composition-based stats. Identities = 84/307 (27%), Positives = 136/307 (44%), Gaps = 26/307 (8%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 MS + K+++L++DGAM T L+ RG + + +PE ++E+H Y Sbjct: 1 MSFRKRV-----KKEVLIIDGAMGTLLQQRGLP--GGWCPEEWNLSHPEAVKEIHKLYLE 53 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGA T ++ A A L + Q K + +V+LA++ + Y A +VAG Sbjct: 54 AGADIITTNTFGAIQLKLADYHLGD-QVKEINQAAVKLAKEVAQPYGA--------MVAG 104 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 SVGP G +L + E + A+++AG DL+ ET + E+ A Sbjct: 105 SVGPLGKFLQPLGT------MTFEEAYQQFYEQCAAMVEAGVDLILFETFGDIGEMRAAL 158 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAAL 239 SFT ++ GT ++A + A+G+NC + + Sbjct: 159 IAAADAGDVPVVASFTFDETGRTFTGTDPETAA-VVAERLGIAAIGVNCSVGPRQLEGVV 217 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 + L T LP++V PN+G KT E +A+Y ++ GA ++GGCC TT Sbjct: 218 RKLTESTNLPVLVSPNAGMPEIIGGKTVFR--ETPEIMAEYAQRFVDYGASILGGCCGTT 275 Query: 300 PADIAAL 306 P I A+ Sbjct: 276 PKHIQAI 282 >UniRef50_D1BKY6 Homocysteine S-methyltransferase n=3 Tax=Veillonella RepID=D1BKY6_VEIPT Length = 341 Score = 304 bits (779), Expect = 2e-81, Method: Composition-based stats. Identities = 117/337 (34%), Positives = 179/337 (53%), Gaps = 31/337 (9%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M++ + ++ ++D L+LDGA+ TELE GC++ LWSAKVL++ P++I+++H+ Y Sbjct: 5 MAKRSAFLDIIKEKDALVLDGALGTELERYGCDIQHKLWSAKVLMDQPDIIKKIHISYLA 64 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQA------- 113 AGA ++ YQAT AGF G ++ L+ SV LA +AR +L Sbjct: 65 AGADIIQSSGYQATVAGFKGLGYGTEEAIELVKLSVRLAVQARNEFLEAKASGALTLRGI 124 Query: 114 ------------------GTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVE 155 LVA SVGPYGA+LADGSEYRG E + FH PR+ Sbjct: 125 KLGEETPEGVKYFSEGALPKPLVAASVGPYGAFLADGSEYRGYPDVQTEYLEVFHIPRLA 184 Query: 156 ALLDAGADLLACETLPNFSEIEALAELLTA---YPRARAWFSFTLRDSEHLSDGTPLRDV 212 + D+L+ ET+P+++E A+A ++ AW +F+ +D H+S G + Sbjct: 185 LFCEENPDILSFETIPSYAEAIAIARAMSDPFTSKGIPAWIAFSCKDGHHVSSGETIIKC 244 Query: 213 VALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGE 272 ++ + +GINC E + ++ + +T P+ VYPN GE YD+ +KTW+ Sbjct: 245 AQMIDKVHPITGIGINCTKPEYVESLIKDIRTVTDKPIAVYPNLGESYDSKTKTWYG--- 301 Query: 273 HCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKAR 309 A DY+ W+ AGA +IGGCCRTTP I + + Sbjct: 302 DAASFVDYVEVWRKAGAEIIGGCCRTTPEIIGDIAKK 338 >UniRef50_Q0BQM8 Homocysteine S-methyltransferase n=1 Tax=Granulibacter bethesdensis CGDNIH1 RepID=Q0BQM8_GRABC Length = 313 Score = 304 bits (779), Expect = 3e-81, Method: Composition-based stats. Identities = 136/307 (44%), Positives = 179/307 (58%), Gaps = 9/307 (2%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 + +L + LLLDGA+ATELE G +L D LWS ++L++NP I VH Y AGA C Sbjct: 5 ISSLFRQARPLLLDGALATELERAGYHLDDPLWSGRLLLDNPAAIAAVHRAYLEAGADCI 64 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTL-----LVAGS 121 TASYQ + G RGL ++ +++ + LA R+ A P A LVAGS Sbjct: 65 ETASYQLSLPGLQRRGLSRGRAMSVLADAARLACSVRDDVWAGLPAAQRRNRIRPLVAGS 124 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 +GPYGA ADGSEY G Y S + AFH PR+ AL GADL+ACET+P+ E A A+ Sbjct: 125 LGPYGACQADGSEYTGRYALSRSQYLAFHAPRMRALAAGGADLIACETVPHLDEALAFAD 184 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQH 241 LL A W SF++RD+ H++DGTPLR V +A P V A+GINC A ++ Sbjct: 185 LLQALS-VPGWVSFSVRDAAHIADGTPLRLCVQAMASCPFVAAIGINCTDPVLVPALIRC 243 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 L LP++VYPN+GE +D V++ W H A+ W GAR++GGCCRT P Sbjct: 244 LRR-GGLPVIVYPNAGEPFDLVTRCWGHRRS--DDWAEQARSWLRLGARIVGGCCRTRPD 300 Query: 302 DIAALKA 308 DI AL+ Sbjct: 301 DIRALRR 307 >UniRef50_B3S7K9 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3S7K9_TRIAD Length = 321 Score = 302 bits (774), Expect = 1e-80, Method: Composition-based stats. Identities = 116/309 (37%), Positives = 173/309 (55%), Gaps = 15/309 (4%) Query: 13 KQDILLLDGAMATELEARGCNLA-DSLWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 ++IL++DGA TEL+ G ++ D LWSA +L+ NP++I+++H Y AGA +TA+Y Sbjct: 2 DKEILVIDGACGTELQRLGYDVDADPLWSASLLLTNPQVIKDLHTSYLNAGADIILTATY 61 Query: 72 QATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAE------NPQAGTLLVAGSVGP 124 QA+ G L EA + A+I +V LA +AR+ + AE N + LV GSVGP Sbjct: 62 QASIPGLVQYADLTEASASAVIAMAVRLAIEARDEFWAEQKACNKNVRRPKPLVVGSVGP 121 Query: 125 YGAYLADGSEYRGDY--HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 +GA DGSE+ G Y ++E + +H+PR+ L+ G DL+A ET+P E AL ++ Sbjct: 122 FGACQHDGSEFHGRYTDEMTIEELKQWHKPRIMELIQNGVDLIAFETIPAEKEAIALIQV 181 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHL 242 L + +AW SF +D HL+ G DV+ + Q+VA+G NC +N +Q Sbjct: 182 LETFRGVKAWLSFVCKDDLHLNHGELFADVMERFRNHNQIVAIGTNCTNPQNVDNLIQSC 241 Query: 243 HGLT--VLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 L P + YPNSGE + +L+DY+ +W G R IGGCCRTTP Sbjct: 242 KRLDAYDKPFIAYPNSGESWSVD---RWDPTIPPVELSDYVQRWIKNGIRWIGGCCRTTP 298 Query: 301 ADIAALKAR 309 +DI ++ + Sbjct: 299 SDILKIRNK 307 >UniRef50_D1HYS9 Whole genome shotgun sequence of line PN40024, scaffold_20.assembly12x (Fragment) n=6 Tax=rosids RepID=D1HYS9_VITVI Length = 330 Score = 302 bits (773), Expect = 1e-80, Method: Composition-based stats. Identities = 135/298 (45%), Positives = 179/298 (60%), Gaps = 9/298 (3%) Query: 18 LLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPAG 77 ++DG +ATELE G +L D LWSA L+ +P+LIR VHLDY AGA ITASYQAT G Sbjct: 24 VIDGGLATELERHGADLNDPLWSATCLIHSPDLIRRVHLDYLEAGASIIITASYQATIQG 83 Query: 78 FAARGLDEAQSKALIGKSVELARKAREAYLAENPQA-----GTLLVAGSVGPYGAYLADG 132 F A+GL +++ L+ +SVE+A +AR+ Y + +LVA SVG YGAYLADG Sbjct: 84 FEAKGLSREEAEVLLRRSVEIACEARDIYHERCAKGTCLEQRPILVAASVGSYGAYLADG 143 Query: 133 SEYRGDYH--CSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL-TAYPRA 189 SEY G Y ++E + FHR RV+ L ++GADL+A ET+PN E +A AELL + Sbjct: 144 SEYSGHYGAAVTLETLKDFHRRRVQVLAESGADLIAFETIPNKLEAKAYAELLDEENIKI 203 Query: 190 RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLP 249 AWFSFT D ++ G L + ++ QVVA+GINC + + +T P Sbjct: 204 PAWFSFTSLDGINVVSGDSLIECASIADSCKQVVAVGINCTPPRFIHGLILLIQKVTTKP 263 Query: 250 LVVYPNSGEHYDAVSKTWHHHGE-HCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 +V+YPNSGE YD V K W Y+ +W+ AGA L GGCCRT+P I A+ Sbjct: 264 VVIYPNSGETYDGVRKEWVKSSGVQDGDFVSYVSKWREAGASLFGGCCRTSPHTIRAI 321 >UniRef50_D2RKX3 Homocysteine S-methyltransferase n=2 Tax=Acidaminococcus RepID=D2RKX3_ACIFE Length = 317 Score = 301 bits (771), Expect = 2e-80, Method: Composition-based stats. Identities = 131/311 (42%), Positives = 181/311 (58%), Gaps = 8/311 (2%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 L+ +LD+ IL++DG+M T LE G +L +SLW+A+VL PEL+++VHLDY+RAG Sbjct: 1 MRQTLKNILDQNKILVIDGSMGTALENLGADLNNSLWTARVLANRPELVKQVHLDYFRAG 60 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYL----AENPQAGTLLV 118 A IT SYQA+ G A G E +++ LI +SV + ++AR+ + +A L + Sbjct: 61 ADAGITCSYQASIPGLVANGFTEQEAEELITRSVTIFQEARQEWWDREGKAAGRAWPLCL 120 Query: 119 AGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 AG VGPYGAYLADGSEYRG Y S E + FHR R E L AGAD+L ET P+ E Sbjct: 121 AG-VGPYGAYLADGSEYRGHYGVSREDLEKFHRRRAELLWQAGADVLLFETQPSLEEALV 179 Query: 179 LAELLTAYPRARAWFSFTLRDSEHLSDGTPL-RDVVALLAGYPQVVALGINCIALENTTA 237 + A W SF+ RD H+ +GTP+ ++ +P+V ALG+NC E + Sbjct: 180 EVSIAKDL-GAAFWVSFSCRDGLHICEGTPIREAAAEVVRQFPEVEALGVNCTKPEYLVS 238 Query: 238 ALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCR 297 + L + P+ VYPNSGE YD V+KTWH G + DY ++ AGA +GGCC Sbjct: 239 LIGELKTASDRPIFVYPNSGEEYDPVTKTWHGVGTDR-KFGDYALEYMKAGAVAVGGCCT 297 Query: 298 TTPADIAALKA 308 T + + A Sbjct: 298 TVADHVRQVAA 308 >UniRef50_B9L045 Methylenetetrahydrofolate reductase n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=B9L045_THERP Length = 624 Score = 300 bits (768), Expect = 5e-80, Method: Composition-based stats. Identities = 87/309 (28%), Positives = 134/309 (43%), Gaps = 22/309 (7%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 +P R +++ +LL DGAM T+L RG L + +P+L+ E+H Y AG Sbjct: 1 MKHPFRDRIEQG-VLLADGAMGTQLYERGIRLDR--CFESANLTHPQLVVEIHRAYILAG 57 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 A+ T ++ A A G+ E + + + ++V AR+ARE + +AG++ Sbjct: 58 AELIETNTFGANRFKLEAYGMAE-RVREINRRAVRHAREAREI------CGVPVFIAGAI 110 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G LA + E+ + R ++EALL+ G DLL ET+ +EI Sbjct: 111 GPSGRLLAPVGT------VAPESLRPVFREQIEALLEGGVDLLIFETMSQLAEIREAIMA 164 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 T G +VVA LA V +G+NC + T L+ Sbjct: 165 AREVCDLPIVAQMTFAADGRTIAGHGPEEVVAALAEL-GVDVIGVNCSVGPRPTLEVLRA 223 Query: 242 L--HGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 + L PN+G + +G AD+ + + G RLIGGCC TT Sbjct: 224 MIAANRWGTALSAMPNAGWPTVVGHRVI--YGASPEYFADFAREAASLGVRLIGGCCGTT 281 Query: 300 PADIAALKA 308 P IAA++ Sbjct: 282 PEHIAAMRR 290 >UniRef50_C1F5Y3 Homocysteine S-methyltransferase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F5Y3_ACIC5 Length = 310 Score = 299 bits (767), Expect = 6e-80, Method: Composition-based stats. Identities = 129/292 (44%), Positives = 170/292 (58%), Gaps = 5/292 (1%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 I +LDG MATELE RG N++ LWSA VL E+PE I+ VHLDY RAG+ C T SYQ + Sbjct: 11 RIRVLDGGMATELERRGFNISGPLWSAHVLDESPEAIQAVHLDYLRAGSDCISTVSYQIS 70 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 G+A + + +SV LA +AR Y EN + +A S+GPYGA L +G+E Sbjct: 71 AQGYAELSRPDPAFATALRRSVALAEEARARYAQENS--RPIWIAASLGPYGAALHNGAE 128 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 + G+Y + + FHR R+ L + GADL+A ET+P+ E A+ LT P AW S Sbjct: 129 FHGNYSITFDDLVEFHRARLAVLAETGADLVAFETIPSLDEARAILTALTHTPNVSAWLS 188 Query: 195 FTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYP 254 FT RD H++ G PL LL QV+ALGINC A + L T P++ YP Sbjct: 189 FTCRDEAHIAHGEPLAACAQLLDSAVQVLALGINCTAPRHVAPLLAAAQSQTRKPVIAYP 248 Query: 255 NSGEHYDAVSKTWHHHGEHCAQLADY---LPQWQAAGARLIGGCCRTTPADI 303 NSGE ++A ++ W + A++ DY QW AAGA+ IGGCCRTTP I Sbjct: 249 NSGESWNAATRAWQGRTDLAAEVKDYQTLAGQWFAAGAQAIGGCCRTTPEHI 300 >UniRef50_C9KQD5 Vitamin B12-dependent methionine synthase family protein n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KQD5_9FIRM Length = 815 Score = 299 bits (767), Expect = 7e-80, Method: Composition-based stats. Identities = 78/295 (26%), Positives = 118/295 (40%), Gaps = 23/295 (7%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 I + DGAM T L+A G + +++PE++R +H Y AGA T ++ A+ Sbjct: 25 IHIFDGAMGTMLQAGGLEAG--GCPELMNIDHPEVVRHIHEAYIEAGATIIETNTFGASR 82 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 GL E + + L +V +A++A VAGS+GP G +++ + Sbjct: 83 LKLDHYGL-EDRVEELNTAAVRIAKEAA---------GTRAKVAGSMGPTGRFISPLGD- 131 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA-YPRARAWFS 194 E A + + AL AG D ET + E+ A P Sbjct: 132 -----LDFEEAYACFKEQASALAKAGVDFFIIETCIDIQEMRAALLASKEVAPAIPVICQ 186 Query: 195 FTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLVVY 253 T D GT + +L + +G+NC E ++ L P+ V Sbjct: 187 LTYSDDGRTVTGTDPQSAAIIL-SHMGADIIGVNCSLGPEQLVPIVKTLAASCDCPISVQ 245 Query: 254 PNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 PN+G H + P+ AAGA +GGCC TTPA I AL+A Sbjct: 246 PNAGMPQLVDG--VTHFPMGPEDFGSWGPKLLAAGATYLGGCCGTTPAHIRALRA 298 >UniRef50_B2VXK3 Homocysteine S-methyltransferase n=2 Tax=Pleosporineae RepID=B2VXK3_PYRTR Length = 319 Score = 299 bits (767), Expect = 7e-80, Method: Composition-based stats. Identities = 157/315 (49%), Positives = 211/315 (66%), Gaps = 8/315 (2%) Query: 1 MSQN---NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLD 57 M+ N L A + K L+LDGA+AT LE G +++ +LWSA +L++ P LI++ HLD Sbjct: 1 MTFTAPPNRLSAHIVKGSPLILDGALATYLETLGADISGALWSASILLDQPSLIKQTHLD 60 Query: 58 YYRAGAQCAITASYQATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQ--AG 114 YYRA A AITASYQA+ G L+E ++K ++ KSVELA++AR+ Y+ E+ Sbjct: 61 YYRANANVAITASYQASIPGLVKHLQLNEKEAKDVVKKSVELAQEARDQYITESTAKVGN 120 Query: 115 TLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFS 174 L +AGSVGPYGA+LADGSEYRGDY E + FHR R++AL++AG D+LACET+P+ + Sbjct: 121 QLFIAGSVGPYGAFLADGSEYRGDYSIPKEEMKDFHRGRIQALVEAGVDILACETIPSKA 180 Query: 175 EIEALAELL-TAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALE 233 E EA+ +LL T + AWF FTLRDSEH+SDGT L ++ AL QVVALG NC+ + Sbjct: 181 ETEAIIDLLTTEFASTEAWFGFTLRDSEHISDGTSLAEIAALFDNVQQVVALGFNCVPDD 240 Query: 234 NTTAALQHLHGLTVLP-LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLI 292 + AAL+ L L LVVYPNSGE ++A ++ W + LA+ +W+ AGA LI Sbjct: 241 LSVAALKTLKPLVKRGTLVVYPNSGEQWNAQAREWEGKRTEGSSLAEKTREWRDAGAGLI 300 Query: 293 GGCCRTTPADIAALK 307 GGCCRTTP DI +K Sbjct: 301 GGCCRTTPKDIGVMK 315 >UniRef50_B9E9X6 Putative uncharacterized protein n=1 Tax=Macrococcus caseolyticus JCSC5402 RepID=B9E9X6_MACCJ Length = 295 Score = 299 bits (766), Expect = 8e-80, Method: Composition-based stats. Identities = 117/306 (38%), Positives = 179/306 (58%), Gaps = 16/306 (5%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M + L +QDI++LDG T +E G ++ LWS+ ++ NPE + +VH + Sbjct: 1 MQLRDKL-----QQDIVILDGGFGTTVEQFGYDVKHELWSSNLIQSNPEAVYKVHKAFVD 55 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 +GA+ +T +YQA+ F G+D+A + + +VELA +A + ++AG Sbjct: 56 SGAEIILTNTYQASVQSFLNIGIDKATACTYLATAVELATRAA---------SNRTIIAG 106 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 S+GPYGA L +GSEY GDY + + +H+ R++ L++AG + A ET+PN EI+A+ Sbjct: 107 SLGPYGAMLGNGSEYTGDYEETEADYIQYHKERLDILIEAGVSVFAFETIPNIEEIKAVR 166 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQ 240 LL YP AW S TL+D +HLSDGTPL V+ ++ V+A G+NC ++ AA+ Sbjct: 167 TLLLDYPHIEAWISVTLKDHDHLSDGTPLEAVIEVVNEIENVLAFGVNCTSVNVIDAAVD 226 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 L L+ PL++YPNSG YDAV K W + A L + P+W+ G ++IGGCC+ P Sbjct: 227 KLITLSDKPLILYPNSGRQYDAVHKVWI--DQEDASLVEAAPRWKEKGVKIIGGCCQVGP 284 Query: 301 ADIAAL 306 +I L Sbjct: 285 GEIKEL 290 >UniRef50_A5VKC8 Homocysteine S-methyltransferase n=10 Tax=Lactobacillus RepID=A5VKC8_LACRD Length = 310 Score = 297 bits (762), Expect = 2e-79, Method: Composition-based stats. Identities = 135/295 (45%), Positives = 184/295 (62%), Gaps = 4/295 (1%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 LL+DGAM+T LE G + +SLW+A VL P L+++VH +Y++AG + AIT +YQA Sbjct: 10 KPLLIDGAMSTALEQLGADTNNSLWTASVLANQPALVKKVHQEYFKAGDRLAITDTYQAN 69 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 F G + ++ +LI ++V LA++AR+ Y E VAG++GPYGAYLA+GSE Sbjct: 70 VPAFIKNGYSKQEAHSLIQRAVVLAKEARDEYQQE--TGIYNYVAGALGPYGAYLANGSE 127 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY-PRARAWF 193 Y G YH S +Q FHRPR+ +L G D++A ET P E+ A +L+ P + Sbjct: 128 YSGAYHLSTIEYQQFHRPRLTDILTVGVDVIAIETQPRLDEVLAELDLVKELAPDTLCYV 187 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVY 253 SF+L+DS HL DGTPL +A Y V A+G+NCI LE TAA++ +H +T P++ Y Sbjct: 188 SFSLKDSTHLPDGTPLAVAARTVAKYTNVFAVGVNCIPLEEVTAAIETVHQVTEKPVIAY 247 Query: 254 PNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 PNS YD +KTW + L DYLPQW AAG ++GGCC TTP DIAAL Sbjct: 248 PNSSATYDPTTKTW-SYPHGRRGLVDYLPQWIAAGLIIVGGCCTTTPQDIAALHE 301 >UniRef50_B0NWZ7 Putative uncharacterized protein n=1 Tax=Clostridium sp. SS2/1 RepID=B0NWZ7_9CLOT Length = 319 Score = 296 bits (757), Expect = 8e-79, Method: Composition-based stats. Identities = 114/308 (37%), Positives = 171/308 (55%), Gaps = 6/308 (1%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 N + ++ + I+++DG+M+T LE RG +L LW+AK+L E PELI++VH +Y++AG Sbjct: 2 MKNSIENIIKENKIMVIDGSMSTPLENRGVSLNSKLWTAKILAEQPELIKQVHKNYFKAG 61 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTL---LVA 119 A C IT SYQA+ G G +++ LI +V++ +AR+ + E + L Sbjct: 62 ADCGITCSYQASIPGLMENGYTLEEAENLIRSAVKIFCEARDEWWEEEGREARRAWPLCL 121 Query: 120 GSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEAL 179 G+ GPYGAYLADGSEYRG+Y + E + FH+ RVE L +AGAD++ ET+P+ E + Sbjct: 122 GAAGPYGAYLADGSEYRGNYGITDEQLKEFHKRRVELLHEAGADIILFETVPSLKEAKVE 181 Query: 180 AELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVAL-LAGYPQVVALGINCIALENTTAA 238 AE+ Y W SF+ + +GTP+ + GYP + +G+NC E T Sbjct: 182 AEIAEEY-GYDYWISFSCLSENIICEGTPIAECATTFAKGYPHLKMIGVNCTKPEYITGL 240 Query: 239 LQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRT 298 + + +P+ VYPNSGE YDAV K W Y + +GA +GGCC T Sbjct: 241 IHKIKENCDIPIGVYPNSGEEYDAVKKVWFGKQ-SALSFEQYAYNYMKSGASAVGGCCTT 299 Query: 299 TPADIAAL 306 + + Sbjct: 300 VAKHVEEV 307 >UniRef50_B1MXY2 Homocysteine S-methyltransferase n=1 Tax=Leuconostoc citreum KM20 RepID=B1MXY2_LEUCK Length = 303 Score = 295 bits (756), Expect = 1e-78, Method: Composition-based stats. Identities = 125/309 (40%), Positives = 184/309 (59%), Gaps = 11/309 (3%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M++ LL + + +LDG + +E++ + +A++LWSA L++ P L+R++H Y+ Sbjct: 1 MTK---FSELLLQGPV-ILDGGLGSEIDKQHIAVANNLWSASALIQAPNLVRDIHQSYFN 56 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGAQ AI +YQA P F GL E ++ LI +V LAR + + ++AG Sbjct: 57 AGAQIAIVDTYQAHPQTFVDSGLSENEAYELIDLAVALARD-----GLKKSEKSLGIIAG 111 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 SVGPYGAYLA+G+EY GDY S++A+QAFHR R++ L+ D+LA ET+PNF E +A+A Sbjct: 112 SVGPYGAYLANGAEYTGDYDLSIQAYQAFHRQRIKRLVHNNVDILALETMPNFKEAQAIA 171 Query: 181 ELLT-AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAAL 239 LL +P A+ SF +HL DGT L VA + Q+ A+GINC A +N A+ Sbjct: 172 LLLQNEFPEVEAYLSFATEVGDHLWDGTRLAHAVAYFNQFEQIKAIGINCTAPDNILPAI 231 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 + T +++YPN+GE Y+ +K W + E +P WQ AGA +IGGCCRT+ Sbjct: 232 MRIKPNTDKKVILYPNAGEVYNPETKRWVTNNE-PINWRRLVPLWQHAGADIIGGCCRTS 290 Query: 300 PADIAALKA 308 P DI + Sbjct: 291 PEDIREIHD 299 >UniRef50_A4XIN5 Methylenetetrahydrofolate reductase n=1 Tax=Caldicellulosiruptor saccharolyticus DSM 8903 RepID=A4XIN5_CALS8 Length = 604 Score = 294 bits (754), Expect = 2e-78, Method: Composition-based stats. Identities = 85/307 (27%), Positives = 128/307 (41%), Gaps = 23/307 (7%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 R L +QDI+L DGAM TEL RG N L + NP+L++ +H DY AG+Q Sbjct: 2 KSFREFLSQQDIVLFDGAMGTELLNRGYNKDFPL--EWANISNPDLVKSIHSDYILAGSQ 59 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP 124 C T ++ A G E Q + + +V++A++ T V GSVGP Sbjct: 60 CIETNTFGANECRLNLYGF-EGQVEKINRNAVKIAKEVA---------GQTAYVIGSVGP 109 Query: 125 YGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 G + G E + + ++ ++ LLD G D + ET + E+ E L Sbjct: 110 LGKPVGSGFE------IDDKRAKEVYKKQLYFLLDEGVDAILFETAASTHEVLIAIEALK 163 Query: 185 AY-PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHL 242 F+ G + V+ L G +G+NC T AL+ Sbjct: 164 ELDSNFPYIVQFSFTRDLTTIYGEDIYKVIEFLKGI-DADVVGLNCGNGPHQTLEALKIF 222 Query: 243 HGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPAD 302 P V PN+G + + A ++ ++ GA++IGGCC TTP Sbjct: 223 SQHLKGPFSVQPNAGYPQLVQGRLV--YSTSANYFASFVDEYVKYGAKIIGGCCGTTPEH 280 Query: 303 IAALKAR 309 I A+K R Sbjct: 281 IKAIKER 287 >UniRef50_B8CZI7 Homocysteine S-methyltransferase n=1 Tax=Halothermothrix orenii H 168 RepID=B8CZI7_HALOH Length = 819 Score = 294 bits (753), Expect = 2e-78, Method: Composition-based stats. Identities = 78/306 (25%), Positives = 137/306 (44%), Gaps = 25/306 (8%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 N + L ++ I++ DGAM T L+A G + + +++ P+ I ++H +Y AG Sbjct: 1 MANDFTSTL-QEKIIIGDGAMGTMLQACGLSSGHA--PESWVIKKPDTIYKIHKEYVAAG 57 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 A T ++ A + GL E + + + K+ LARKA G + VAGSV Sbjct: 58 AGLIETNTFGANRLKLKSLGL-EDKIEEINVKATGLARKAA----------GKVFVAGSV 106 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G + + S + + + ++ L+ AG D++ ET+ + E+ A Sbjct: 107 GPTGKLMEPHGD------LSFDRARDVFKEQISYLVHAGVDVVIIETMSDLKELRAAVVA 160 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQH 241 + T + G+P +VVA++ V +G+NC+ +E ++ Sbjct: 161 AKEF-NVPVIAQMTFTERGITLTGSPP-EVVAIVLDKMGVDVIGVNCVAGIEEALIVIKK 218 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 + +T PL V+PN+G +T + + D +P+ +LIGGCC T P Sbjct: 219 MSRVTSKPLSVFPNAGLPESKGGETV--YPQTPDAFTDKIPELLKYNVKLIGGCCGTNPR 276 Query: 302 DIAALK 307 I +K Sbjct: 277 FIKGIK 282 >UniRef50_Q2JJL4 Methionine synthase n=30 Tax=Bacteria RepID=Q2JJL4_SYNJB Length = 1224 Score = 294 bits (752), Expect = 3e-78, Method: Composition-based stats. Identities = 79/319 (24%), Positives = 132/319 (41%), Gaps = 28/319 (8%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREVHL 56 +P L ++ +++ DGAM + L+A+ AD + +++ PE + VH Sbjct: 1 MTHPFLQHL-QERVIVFDGAMGSSLQAQNLTAADFGGPELEGCNEMLVLTKPEAVERVHR 59 Query: 57 DYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTL 116 + GA T ++ AT A G+ E ++ L + LA++ + Sbjct: 60 GFLEVGADVVETNTFGATSIVLAEYGIPE-KAYELNVAAARLAKRVAAEFATP---EKPR 115 Query: 117 LVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEI 176 VAGS+GP H S + +A + +V+ L+D GADLL ET + + Sbjct: 116 FVAGSIGPTTKL-------PTLGHISFDEMRAAYEEQVQGLVDGGADLLIIETCQDILQT 168 Query: 177 EALAEL-----LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-I 230 +A R S T + GT + +A+L YP + LG+NC Sbjct: 169 KAALVAVQQEFARRGIRLPVVVSLTFEVQGTMLVGTEIGAALAILEPYP-IDVLGLNCAT 227 Query: 231 ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ-AAGA 289 + +++L + P+ PN+G + K H+ QL +L + G Sbjct: 228 GPDKMVEHIRYLSRHSPFPISCIPNAGLPENIGGKA--HYKLTPEQLRFHLEHFVRDLGV 285 Query: 290 RLIGGCCRTTPADIAALKA 308 ++GGCC T P IAAL Sbjct: 286 AVVGGCCGTRPEHIAALVE 304 >UniRef50_A8YVC8 Homocysteine S-methyltransferase n=2 Tax=Lactobacillus helveticus RepID=A8YVC8_LACH4 Length = 331 Score = 293 bits (750), Expect = 6e-78, Method: Composition-based stats. Identities = 119/302 (39%), Positives = 166/302 (54%), Gaps = 5/302 (1%) Query: 7 LRALLDK-QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQC 65 + L+ + + ++LDGAM+ ELE +G + LW+A L+ + I + H DY+ AGA+ Sbjct: 31 MMNLISRAKKGIVLDGAMSDELERQGVKTNNKLWTATALINELDKIYQAHWDYFTAGAEL 90 Query: 66 AITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY 125 IT +YQA F G E +++ I +V++A+KAR+ Y E VAG+VG Y Sbjct: 91 VITDTYQANVQAFTQAGYSEQEAEKFIRDAVKVAKKARDDY--EQKTGKHNYVAGTVGSY 148 Query: 126 GAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA 185 AYLADG+EYRGDY S + AFH PR+ +L DL+A ET P E A+ L Sbjct: 149 SAYLADGNEYRGDYELSELEYLAFHLPRLRQILAEKPDLIALETQPKLDEPLAVLNWLKE 208 Query: 186 -YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHG 244 + SFTL+D+ H+SDGT L V+ + + QV A+GINCI+ + AL+ + Sbjct: 209 NASDYPVYVSFTLKDATHISDGTTLEQAVSAVDKFEQVFAIGINCISPDLVAPALKEIGK 268 Query: 245 LTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 T PLV+YPN G YD K W E +W GARLIGGCC T P +I Sbjct: 269 YTFKPLVLYPNLGASYDPKIKQWREFKEKFD-FNKLTKKWYQEGARLIGGCCTTGPTEIK 327 Query: 305 AL 306 + Sbjct: 328 QM 329 >UniRef50_C3ZEE1 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae RepID=C3ZEE1_BRAFL Length = 315 Score = 292 bits (748), Expect = 9e-78, Method: Composition-based stats. Identities = 116/302 (38%), Positives = 165/302 (54%), Gaps = 14/302 (4%) Query: 18 LLDGAMATELEARGCNLA-DSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 +LDG +ATEL+ G ++ D LWSA++L NP I++VH + AG+ ITA+YQA+ Sbjct: 5 VLDGGLATELDFAGFDINNDPLWSARLLATNPAAIKQVHKSFLSAGSDVIITATYQASVP 64 Query: 77 GFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQA-----GTLLVAGSVGPYGAYLA 130 GF G+ ++ L+ V +A++A + E + L AGSVGPYGA L Sbjct: 65 GFQEYLGVSVEEAHKLMDHGVRIAKQACLEFCKEQDKGDFPGRRNPLAAGSVGPYGACLH 124 Query: 131 DGSEYRGDY--HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPR 188 D SEY G+Y S+E Q +HRPR+ L+ +GAD++A ET+P E AL +LL +P Sbjct: 125 DASEYTGEYVDSMSIEELQRWHRPRLGQLITSGADMVAIETIPAVKEAAALVQLLREFPN 184 Query: 189 ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVL 248 RAW +F+ +D H G + +A + PQV A G NC E+ LQ L Sbjct: 185 TRAWVTFSCKDGLHTCHGESFPEAIAAVLKSPQVFAAGANCCMPEHVAPLLQKARELCKD 244 Query: 249 P---LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAA 305 P + YPNSGE + A + L+ ++P+W GAR IGGCCRT P DI Sbjct: 245 PAKFFIAYPNSGEKWAAGTGWHGKADCRP--LSTFVPEWLDHGARWIGGCCRTRPDDIKD 302 Query: 306 LK 307 ++ Sbjct: 303 IR 304 >UniRef50_Q4S116 Chromosome 1 SCAF14770, whole genome shotgun sequence n=5 Tax=Euteleostomi RepID=Q4S116_TETNG Length = 372 Score = 292 bits (747), Expect = 1e-77, Method: Composition-based stats. Identities = 127/340 (37%), Positives = 177/340 (52%), Gaps = 33/340 (9%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNL-ADSLWSAKVLVENPELIREVHLDYY 59 M + L L +LDG +AT+LEA+G +L D LWSA++L NP+ IR+ H + Sbjct: 1 MESSPRLNRYLCDDGPFILDGGLATDLEAQGVHLQGDPLWSARLLYTNPQAIRDAHCRFL 60 Query: 60 RAGAQCAITASYQATPAGFAAR-GLDEAQSKALIGKSVELARKAREAY------------ 106 +GA TA+YQA+ GF + +K LI V+LA++A E++ Sbjct: 61 LSGADVISTATYQASVEGFMDHLNVSSEGAKELIMSGVQLAKEAVESFVPGTNPNTTVQS 120 Query: 107 --------------LAENPQAGTLLVAGSVGPYGAYLADGSEYRGDYH--CSVEAFQAFH 150 + LVAGS+GPYGA+L +GSEY GDY SV+ +A+H Sbjct: 121 GEGKVNSEGSEGLAGQCSSGRRCPLVAGSLGPYGAFLHNGSEYTGDYAEKMSVQELKAWH 180 Query: 151 RPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSFTLRDSEHLSDGTPLR 210 RP+VE L A AD+LA ET+P+ E EAL ELL +P +AW S + +D + LSDG+ R Sbjct: 181 RPQVECLAAAEADVLAFETIPSIKEAEALVELLKEFPNTKAWLSLSCKDVKRLSDGSLFR 240 Query: 211 DVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLV--VYPNSGEHYDAVSKTWH 268 D V + Q++A+G+NC E L L + VYPNSGE +D + W Sbjct: 241 DAVQIANRSEQLIAVGVNCCPPELVEPLLDSARTLLSPEISWVVYPNSGESWDPE-QGWC 299 Query: 269 HHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 L + W GA LIGGCCR +PA +A L+ Sbjct: 300 TSEAALPALLEMSGTWVKQGAALIGGCCRISPAHVAKLRR 339 >UniRef50_A0Q0N0 5-methyltetrahydrofolate--homocysteine methyltransferase, putative n=42 Tax=Bacteria RepID=A0Q0N0_CLONN Length = 808 Score = 291 bits (746), Expect = 2e-77, Method: Composition-based stats. Identities = 74/299 (24%), Positives = 122/299 (40%), Gaps = 23/299 (7%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K +IL+ DGAM T L+ G NL +S K+ + LI ++H Y AGA T ++ Sbjct: 15 KDNILIFDGAMGTMLQKSGLNLGES--PEKLNFSHENLIIDIHKKYIEAGANVITTNTFG 72 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A + +I K+V LA KA+E +A +GP G L Sbjct: 73 ANELKLKNTSFS---VEDVIYKAVSLAIKAKE--------DTNCFIALDIGPIGQLLEPM 121 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 + E + +++A + AG DL+ ET+ + E++A + Sbjct: 122 GTLK------FEDAINIFKRQIKAGVKAGVDLILIETMTDLYEMKAAILAAKETCDLPIF 175 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLV 251 + + + G + L V A+G+NC + ++ T LP++ Sbjct: 176 ATMSFENDGRTFTGCLPESMAVTLEAL-GVTAVGVNCSLGPKELKPIVKKTLEHTNLPVI 234 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKARS 310 V PN+G ++ + + +Y+ G +IGGCC TTP I LK+ S Sbjct: 235 VQPNAGLPTIVNGQS--LYTITPEEFCNYVESLIDMGVSIIGGCCGTTPDFIKCLKSMS 291 >UniRef50_C8W2L3 Homocysteine S-methyltransferase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8W2L3_DESAS Length = 801 Score = 291 bits (744), Expect = 3e-77, Method: Composition-based stats. Identities = 81/299 (27%), Positives = 129/299 (43%), Gaps = 23/299 (7%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 + IL+ DGAM T L+A G + + ++NPE ++ +H Y +AGA T ++ Sbjct: 9 EKILVFDGAMGTMLQAAGLRAGE--CPELINLKNPETVKNIHRQYVKAGADIVETNTFGG 66 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 + GL + + + +V LA+++ + G LVA SVGP G + Sbjct: 67 SRLKLLEYGLAD-KVAEINASAVRLAKESAD---------GQALVALSVGPTGKLMFPNG 116 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE-ALAELLTAYPRARAW 192 + + ++ A AGAD++ ET+ + EI AL A P Sbjct: 117 ------PLTFDEAHHVFSEQISAGAAAGADMICIETMSDLGEIRAALLAAKDAAPGVPVI 170 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLV 251 S T ++ GT V L +G NC ++ + +PL+ Sbjct: 171 CSMTFEPNKRTLMGTDPVAAVITLQAL-GADIIGANCSGGPGELLEVIEEMARYARVPLI 229 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKARS 310 V PN+G +T A++ +Y+P+ AAGA LIGGCC T+P I +K RS Sbjct: 230 VQPNAGMPMLEGDRTV--FPLSAAEMGEYVPKLAAAGASLIGGCCGTSPEYIRVIKERS 286 >UniRef50_A8KB71 Zgc:171603 protein n=4 Tax=Clupeocephala RepID=A8KB71_DANRE Length = 311 Score = 290 bits (743), Expect = 4e-77, Method: Composition-based stats. Identities = 119/301 (39%), Positives = 175/301 (58%), Gaps = 11/301 (3%) Query: 15 DILLLDGAMATELEARGCNL-ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 +LDG +ATELEA G L D LWSA+VL +P+ I++VH Y ++G+ TA+YQA Sbjct: 8 SPFILDGGLATELEASGFLLQGDPLWSARVLHTDPQAIKDVHYRYLQSGSDVITTATYQA 67 Query: 74 TPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENP--QAGTLLVAGSVGPYGAYLA 130 + GF G+ +++ ++ +V+LA++ +++++P LVAGSVGPYG++L Sbjct: 68 SIEGFVKYLGVQPEEAQHMMMSAVQLAKETVSEFISQSPMSDRREPLVAGSVGPYGSFLH 127 Query: 131 DGSEYRGDYH--CSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPR 188 DGSEY G Y +VE + +HRP+++ L+ AGADL+A ET+P E EAL E+L +P Sbjct: 128 DGSEYTGAYEDKMTVEELKDWHRPQIQCLVKAGADLVAMETIPGLKEAEALVEVLKEFPE 187 Query: 189 ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHL--HGLT 246 +AW SF+ +D+ +S G + V + Q+VA+G+NC L+ H Sbjct: 188 TKAWLSFSCKDNNSISSGRRFSEAVEMACRSTQLVAVGVNCCPAPLVKPLLESAKSHKRA 247 Query: 247 VLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 L VVYPNSGE +D + A+ +W+A GA IGGCCR PADI L Sbjct: 248 DLSWVVYPNSGEGWDVTTGWKTEMRTS---FANLSLEWKAQGALWIGGCCRVRPADITEL 304 Query: 307 K 307 K Sbjct: 305 K 305 >UniRef50_B9MN09 Methylenetetrahydrofolate reductase n=2 Tax=root RepID=B9MN09_ANATD Length = 605 Score = 290 bits (742), Expect = 5e-77, Method: Composition-based stats. Identities = 80/309 (25%), Positives = 130/309 (42%), Gaps = 23/309 (7%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 R L +Q I++ DGAM T+L RG ++ L V NPEL++++H DY AG Sbjct: 1 MKKSFREFLKEQAIVIFDGAMGTQLLLRGFSVDFPL--EWANVANPELVKQIHTDYILAG 58 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 A C T ++ A G E + + + +V +A++ E + V GSV Sbjct: 59 ATCVETNTFGANECKLKVFGF-ENEVERINRSAVRIAKEVAE---------NKVYVIGSV 108 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G + +G E + + ++ ++ LLD G D + ET + E++ E Sbjct: 109 GPLGKPVGNGFE------IDDKKAKDVYKRQLYFLLDEGVDAIIFETAASTHEVQIAIEA 162 Query: 183 LTAYPRA-RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQ 240 L F+ G + V+ L +G+NC + T AL+ Sbjct: 163 LKELNDKIPYIIQFSFTKELSTVYGEDIYRVIEFL-KSTNADVVGLNCGNGPQKTLEALK 221 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 P V PN+G + + A ++P++ GA++IGGCC T P Sbjct: 222 IFSQHLKGPFSVQPNAGYPQLIQGRPVFSTSAN--YFASFVPEYIKLGAKIIGGCCGTGP 279 Query: 301 ADIAALKAR 309 I A+K + Sbjct: 280 EHIKAVKEK 288 >UniRef50_B0RCV4 Homocysteine s-methyltransferase n=15 Tax=Actinomycetales RepID=B0RCV4_CLAMS Length = 301 Score = 289 bits (741), Expect = 6e-77, Method: Composition-based stats. Identities = 128/310 (41%), Positives = 176/310 (56%), Gaps = 14/310 (4%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M++ PL L+LDG + T LEARG +L+D LWSA+VL + P+ +R H +Y+R Sbjct: 1 MTRPRPL-----PNRPLVLDGGLGTLLEARGHDLSDPLWSARVLADEPDAVRAAHAEYFR 55 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENP--QAGTLLV 118 AGA AITASYQ FAARGL A+++ L+ SV LA +AR+ ++ + Sbjct: 56 AGADVAITASYQVGFEAFAARGLSAAETEELLRASVRLAAEARDEVAQDDAPGAGRDRWI 115 Query: 119 AGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 A SVGPYGA L DGSEY + + +H PR L D+GADLLACET+P+ E A Sbjct: 116 AASVGPYGATLGDGSEYAASSGLTRAELRRWHAPRFAVLADSGADLLACETVPSLDEGRA 175 Query: 179 LAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAA 238 L +L A AW +FT+ L G P+ + L G ++VA+GINC E AA Sbjct: 176 LVDLAR-GSGASAWLAFTV-QGGRLRSGEPMAEGFRLANGADEIVAVGINCAHPEEVPAA 233 Query: 239 LQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRT 298 + G+T P+ VYPNSGE +DAV++ W + + W AAGA ++GGCCR Sbjct: 234 IAAARGVTDRPVAVYPNSGERWDAVARAWGGDPALPS-----VDAWIAAGASIVGGCCRV 288 Query: 299 TPADIAALKA 308 P +I ++ Sbjct: 289 GPDEIRRMRD 298 >UniRef50_A6TTI3 Homocysteine S-methyltransferase n=6 Tax=Firmicutes RepID=A6TTI3_ALKMQ Length = 789 Score = 289 bits (740), Expect = 8e-77, Method: Composition-based stats. Identities = 73/297 (24%), Positives = 119/297 (40%), Gaps = 26/297 (8%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K+ +L+ DGAM T L+ G + +E+PELI+++H + RAGAQ T ++Q Sbjct: 8 KEGMLIFDGAMGTMLQKSGLKVG--ALPEIYNIEHPELIQQIHERFVRAGAQVVTTNTFQ 65 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A + +I +++A+ +G VA +GP G + Sbjct: 66 ANELKLKDSIYS---LEEIIEGGIKVAK-----------ASGAPYVALDIGPLGQMMKPL 111 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 E S + + +V+A + AGAD + ET+ + E +A Sbjct: 112 GE------ISFDRAYDIFKRQVQAGVKAGADCILIETISDLYEAKAAILAAKENSDLPVL 165 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLV 251 + T ++ GT L+ V ALG+NC + L + +P++ Sbjct: 166 CTMTFQEDGRTFTGTDPMTA-TLVLQSLGVDALGVNCSLGPKEMLPILSDILKYAKVPVM 224 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 V N+G T + A Y + G ++GGCC TTP I ALK Sbjct: 225 VQSNAGLPRLEGDDTI--FPASPEEFALYGREMAELGVGILGGCCGTTPEHIQALKK 279 >UniRef50_Q5M5A7 Homocysteine S-methyltransferase (S-methylmethionine) n=21 Tax=Streptococcus RepID=Q5M5A7_STRT2 Length = 322 Score = 289 bits (739), Expect = 1e-76, Method: Composition-based stats. Identities = 128/308 (41%), Positives = 181/308 (58%), Gaps = 9/308 (2%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 + L+ L+L GA+ TE+EA G +++ LWSAK L+E E+I+E+H Y AGA Sbjct: 10 FKDYLENNSPLILHGALGTEMEALGYDISGKLWSAKYLLEKSEVIQELHETYVAAGADLI 69 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYL-----AENPQAGTLLVAGS 121 T+SYQAT G GL E ++ +I +V LA+ AR+ E + L++G Sbjct: 70 TTSSYQATLPGLVEAGLTEKAAEQIIALTVRLAKAARDKVWGALDETEKAKRPYPLISGD 129 Query: 122 VGPYGAYLADGSEYRGDYH-CSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 VGPY AYLA+GSEY GDY +++ + FHRPR++ LLD G DLLA ET+PN E +AL Sbjct: 130 VGPYAAYLANGSEYSGDYGQITIKELKDFHRPRIQILLDQGVDLLALETIPNRLETQALI 189 Query: 181 E-LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAAL 239 E L +P A A+ SFT++ + +SDGT L ++ L++ Q++A+GINC + AL Sbjct: 190 ELLAEEFPEAEAYMSFTVQIPDAISDGTSLAEMAKLVSQSNQILAVGINCSSPLLYNQAL 249 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW-QAAGARLIGGCCRT 298 L L+ YPNSGE YD S+TW + L ++ W G +++GGCCRT Sbjct: 250 AFLKN-AGKALITYPNSGEVYDGDSQTWKPKDKDALTLVEHSKYWHAHFGVKILGGCCRT 308 Query: 299 TPADIAAL 306 P DI AL Sbjct: 309 RPNDIKAL 316 >UniRef50_Q4Q0C9 Homocysteine S-methyltransferase, putative n=3 Tax=Leishmania RepID=Q4Q0C9_LEIMA Length = 339 Score = 289 bits (739), Expect = 1e-76, Method: Composition-based stats. Identities = 159/302 (52%), Positives = 201/302 (66%), Gaps = 8/302 (2%) Query: 10 LLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITA 69 L D +++LDG +ATELE RGC+L D LWS KVL+E+P+ ++ V L Y RAGA+C ITA Sbjct: 24 LADPNYVVMLDGGLATELETRGCDLRDPLWSGKVLLESPQQLQNVALAYLRAGARCIITA 83 Query: 70 SYQATPAGFAARG-LDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 SYQ TP L E + A I +SV +A+ ARE +L E PQA + VAGSVGPYGAY Sbjct: 84 SYQITPQSLMEHRRLTEDAAVAAIEESVRIAQSARERHLREKPQAAPIFVAGSVGPYGAY 143 Query: 129 LADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT-AYP 187 LADGSEYRGDY S E F+ FHR R+ ALL AGAD+LA ET P+ +E+ A+ LL +P Sbjct: 144 LADGSEYRGDYVRSAEEFKEFHRLRIAALLRAGADVLAIETQPSAAEVRAIVALLQEEHP 203 Query: 188 RARAWFSFT---LRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHG 244 RAW SFT + E +SDGT D+++ L PQ+VA+G+NCI + +A L HLH Sbjct: 204 NCRAWVSFTTSRISPVEAISDGTKWADIISFLEKAPQIVAVGVNCIPMAEASAVLAHLHT 263 Query: 245 LTVLPLVVYPNSGEHYDAVSKTWHH---HGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 LT +PLVVY NSGE YDAV++TWH L +W + GARL+GGCCRT P+ Sbjct: 264 LTTMPLVVYTNSGESYDAVTRTWHPISMSDGTTLSLGALAREWASHGARLVGGCCRTGPS 323 Query: 302 DI 303 DI Sbjct: 324 DI 325 >UniRef50_C3WBE7 Methionine synthase n=1 Tax=Fusobacterium mortiferum ATCC 9817 RepID=C3WBE7_FUSMR Length = 1084 Score = 288 bits (737), Expect = 2e-76, Method: Composition-based stats. Identities = 67/308 (21%), Positives = 121/308 (39%), Gaps = 25/308 (8%) Query: 13 KQDILLLDGAMATELEARGCNLADSL----WSAKVLVENPELIREVHLDYYRAGAQCAIT 68 ++ IL+LDGAM T ++ N D L + + + P++I+++HL Y AGA T Sbjct: 11 QKRILVLDGAMGTAIQKYNLNSDDYLGKKGCNEILNITRPDIIKDIHLKYIEAGADIIET 70 Query: 69 ASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 S+ G E ++ + +S ELA++ + +AGS+GP Sbjct: 71 NSFNCNKISLNEYGFSE-RAYEIAKRSAELAKEV------TTTSEKKIYIAGSIGPTNKT 123 Query: 129 LA-DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY- 186 L + D + + + ++E L+D G D+L ET+ + + Sbjct: 124 LTIPSGKNPYDRDLEFDYLKEAYSEQIEGLIDGGVDILLIETIFDGLNAKCAVISAEEVM 183 Query: 187 ----PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQH 241 S T+ + G + ++ L +++ G NC + + Sbjct: 184 KRKNINLPIMISATVNKEGKIFTGQSIESLIVALDRES-IISYGFNCSFGAKELIPLTKK 242 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQA-AGARLIGGCCRTTP 300 L T P+ +YPN+G + E A+YL + ++GGCC TT Sbjct: 243 LGKFTKKPISLYPNAGLP-----NEDGEYLESPDITANYLKELVDNQEVNILGGCCGTTF 297 Query: 301 ADIAALKA 308 I ++ Sbjct: 298 EHIKSIAN 305 >UniRef50_Q0AX05 Methionine synthase (B12-dependent) n=1 Tax=Syntrophomonas wolfei subsp. wolfei str. Goettingen RepID=Q0AX05_SYNWW Length = 839 Score = 287 bits (734), Expect = 4e-76, Method: Composition-based stats. Identities = 73/298 (24%), Positives = 122/298 (40%), Gaps = 22/298 (7%) Query: 11 LDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITAS 70 L + IL+LDGAM T L+ RG + V NP ++ ++H Y AGA + + Sbjct: 8 LLQSRILILDGAMGTMLQERGMVPGE--CPELFGVNNPLILEDIHYQYMEAGADIIQSNT 65 Query: 71 YQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLA 130 + A GL + + + +++ +AR G LVA S+GP G L Sbjct: 66 FGGNRFKLAEYGLQD-RVAEINAEAIRIAR---------AGARGKALVAASIGPSGKLLQ 115 Query: 131 DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRAR 190 + A ++ + AGADL++ ET+ + E+ A + R Sbjct: 116 PFG------NADFAELYAAFTEQMLSCEKAGADLISIETMTDIGEMRAALIAACSNTRLP 169 Query: 191 AWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLP 249 T GT + ++ Q +A+G NC ++ + + + Sbjct: 170 VIAHMTFEPGGRTLMGTDPLTALIIMEAL-QPLAIGANCSGGARELLPIIEEMGRYSSVF 228 Query: 250 LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 L V PN+G +T + ++A+Y + + GA +IGGCC TTP I A+ Sbjct: 229 LSVEPNAGLPQLLGERTV--FPDRPEEMAEYALKLRDVGANIIGGCCGTTPEHIKAIA 284 >UniRef50_D1CBD0 Methylenetetrahydrofolate reductase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CBD0_THET1 Length = 629 Score = 286 bits (733), Expect = 5e-76, Method: Composition-based stats. Identities = 85/307 (27%), Positives = 133/307 (43%), Gaps = 20/307 (6%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 +P L+K IL DGA+ T+L RG S ++ + +P L+ VH+DY RAG Sbjct: 1 MKDPFVERLEKGPIL-SDGAIGTQLYERGVPYGKSF--DELNIVDPSLVSGVHIDYLRAG 57 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 A+ T ++ A GL E + + + + V++AR+ARE +AGSV Sbjct: 58 AEIITTNTFGANRIRLKEFGL-EKKVRDINLRGVKIAREAREIV------GVPAFIAGSV 110 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G +EY + R ++EALL+ GAD++ ET E+ E+ Sbjct: 111 GPIGR---PATEYNS---LTDRVIGDTFREQIEALLEGGADVIMFETFSELEELLIAIEV 164 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 + + E G D V L V +G+NC + + T + Sbjct: 165 AKEVCELPIIAQMSFGEDELTHGGDTPEDFVRALKD-SDVDVIGVNCSVGPQGTLDVVMR 223 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 L + PN+G + A+Y ++ +AGA ++GGCC TTPA Sbjct: 224 LIAAGAHRVSAQPNAGLPSRRGQH--FVYISTPEYFAEYAKKFVSAGAVIVGGCCGTTPA 281 Query: 302 DIAALKA 308 I+A+ A Sbjct: 282 HISAMAA 288 >UniRef50_D1BQ67 Homocysteine S-methyltransferase n=4 Tax=Veillonellaceae RepID=D1BQ67_VEIPT Length = 811 Score = 286 bits (733), Expect = 5e-76, Method: Composition-based stats. Identities = 67/300 (22%), Positives = 121/300 (40%), Gaps = 27/300 (9%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 + + DGAM T L+A G + VE PE+++ +H Y + G+ T ++ A Sbjct: 1 MYIFDGAMGTMLQAAGLE--EGYCPELFNVERPEVVKNIHAQYLQHGSDVITTNTFGACG 58 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 L + + + + +V++A++A +AGS+GP G +L Sbjct: 59 LKLEDYDLQD-RVREINIAAVKVAKEAIAEVKPS------ARIAGSMGPTGRFLQPLG-- 109 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA--------ELLTAYP 187 + S + +R + EAL++ G D + ET+ + E+ A Sbjct: 110 ----NMSFDDIYDTYREQAEALIEGGVDFIIIETIIDVQEMRAALLASLDAREAAGKTKE 165 Query: 188 RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLT 246 + F+ + GTP +++ +GINC E T ++ + +T Sbjct: 166 DVQIICQFSFSEDGRTITGTPPAVATSIVEAI-GADIIGINCSLGPEQITPLIKEIASVT 224 Query: 247 VLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 LP+ PN+G +T ++ + AG +GGCC TTPA I ++ Sbjct: 225 NLPISCQPNAGMPQLINKQTV--FPLTAEEMGPLMLDIVDAGTSYVGGCCGTTPAHIQSI 282 >UniRef50_Q99707 Methionine synthase n=289 Tax=cellular organisms RepID=METH_HUMAN Length = 1265 Score = 286 bits (731), Expect = 9e-76, Method: Composition-based stats. Identities = 74/330 (22%), Positives = 135/330 (40%), Gaps = 33/330 (10%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEA--------RGCNLADSLWS-----AKVLVENP 48 + + + A+L K I++LDG M T ++ RG D + + P Sbjct: 17 TLRDEINAILQK-RIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQP 75 Query: 49 ELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLA 108 ++I ++H +Y AGA T ++ +T A GL E + + S +ARKA E Sbjct: 76 DVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGL-EHLAYRMNMCSAGVARKAAEEVTL 134 Query: 109 ENPQAGTLLVAGSVGPYGAYLA--DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLA 166 + VAG++GP L+ E + + + ++ + + LLD G D+L Sbjct: 135 Q--TGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILL 192 Query: 167 CETLPNFSEIEALAELLT-----AYPRARAWFSFT-LRDSEHLSDGTPLRDVVALLAGYP 220 ET+ + + +A L Y + S T + S G V + + Sbjct: 193 IETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISV-SHG 251 Query: 221 QVVALGINCI-ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLAD 279 + + +G+NC ++ + T ++ YPN+G T+ + E + +A Sbjct: 252 EPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLP-----NTFGDYDETPSMMAK 306 Query: 280 YLPQWQAAG-ARLIGGCCRTTPADIAALKA 308 +L + G ++GGCC +TP I + Sbjct: 307 HLKDFAMDGLVNIVGGCCGSTPDHIREIAE 336 >UniRef50_B4DST3 cDNA FLJ56487, highly similar to Methionine synthase (EC 2.1.1.13) n=1 Tax=Homo sapiens RepID=B4DST3_HUMAN Length = 1118 Score = 286 bits (731), Expect = 9e-76, Method: Composition-based stats. Identities = 74/330 (22%), Positives = 135/330 (40%), Gaps = 33/330 (10%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEA--------RGCNLADSLWS-----AKVLVENP 48 + + + A+L K I++LDG M T ++ RG D + + P Sbjct: 17 TLRDEINAILQK-RIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQP 75 Query: 49 ELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLA 108 ++I ++H +Y AGA T ++ +T A GL E + + S +ARKA E Sbjct: 76 DVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGL-EHLAYRMNMCSAGVARKAAEEVTL 134 Query: 109 ENPQAGTLLVAGSVGPYGAYLA--DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLA 166 + VAG++GP L+ E + + + ++ + + LLD G D+L Sbjct: 135 Q--TGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILL 192 Query: 167 CETLPNFSEIEALAELLT-----AYPRARAWFSFT-LRDSEHLSDGTPLRDVVALLAGYP 220 ET+ + + +A L Y + S T + S G V + + Sbjct: 193 IETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISV-SHG 251 Query: 221 QVVALGINCI-ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLAD 279 + + +G+NC ++ + T ++ YPN+G T+ + E + +A Sbjct: 252 EPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLP-----NTFGDYDETPSMMAK 306 Query: 280 YLPQWQAAG-ARLIGGCCRTTPADIAALKA 308 +L + G ++GGCC +TP I + Sbjct: 307 HLKDFAMDGLVNIVGGCCGSTPDHIREIAE 336 >UniRef50_B7ZLW7 MTR protein n=1 Tax=Homo sapiens RepID=B7ZLW7_HUMAN Length = 1214 Score = 286 bits (731), Expect = 1e-75, Method: Composition-based stats. Identities = 74/330 (22%), Positives = 135/330 (40%), Gaps = 33/330 (10%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEA--------RGCNLADSLWS-----AKVLVENP 48 + + + A+L K I++LDG M T ++ RG D + + P Sbjct: 17 TLRDEINAILQK-RIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQP 75 Query: 49 ELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLA 108 ++I ++H +Y AGA T ++ +T A GL E + + S +ARKA E Sbjct: 76 DVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGL-EHLAYRMNMCSAGVARKAAEEVTL 134 Query: 109 ENPQAGTLLVAGSVGPYGAYLA--DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLA 166 + VAG++GP L+ E + + + ++ + + LLD G D+L Sbjct: 135 Q--TGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILL 192 Query: 167 CETLPNFSEIEALAELLT-----AYPRARAWFSFT-LRDSEHLSDGTPLRDVVALLAGYP 220 ET+ + + +A L Y + S T + S G V + + Sbjct: 193 IETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISV-SHG 251 Query: 221 QVVALGINCI-ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLAD 279 + + +G+NC ++ + T ++ YPN+G T+ + E + +A Sbjct: 252 EPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLP-----NTFGDYDETPSMMAK 306 Query: 280 YLPQWQAAG-ARLIGGCCRTTPADIAALKA 308 +L + G ++GGCC +TP I + Sbjct: 307 HLKDFAMDGLVNIVGGCCGSTPDHIREIAE 336 >UniRef50_A9B657 Methylenetetrahydrofolate reductase n=1 Tax=Herpetosiphon aurantiacus ATCC 23779 RepID=A9B657_HERA2 Length = 617 Score = 284 bits (727), Expect = 3e-75, Method: Composition-based stats. Identities = 77/308 (25%), Positives = 129/308 (41%), Gaps = 22/308 (7%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 NP L Q LL DGAM T+L RG + + + + P+++RE+H Y AG Sbjct: 1 MANPFLEQL-GQRALLCDGAMGTQLYGRGIDFDE--CFDALNLTQPDVVREIHQSYIEAG 57 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 A T +Y A GL + + + + + ++LAR+ARE L+AG+V Sbjct: 58 ADIIETNTYGANRFKLEPFGLAD-KVRQINHRGMKLAREAREI------AGTNTLIAGAV 110 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G L + +A ++ LL+ GADLL ET + E+ + Sbjct: 111 GPLGVLLQPYG------PLTEQAAHEAFAEQIGTLLEQGADLLMFETFSDLREMLIAVKA 164 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 T + G +VV L V +G+NC + + +Q Sbjct: 165 AKQVGDLPIVAQMTFAEDGRTVLGNTPEEVVRKLVEL-GVAVVGVNCSVGSQRVFRVVQS 223 Query: 242 LHGLTV-LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ-AAGARLIGGCCRTT 299 + + +P+ PN+G + ++ + + +ADY + +++GGCC TT Sbjct: 224 MRAVNPTIPISAQPNAGWPTERHNRVF--YPSSPEYMADYARRMVEELNVQIVGGCCGTT 281 Query: 300 PADIAALK 307 P I+ + Sbjct: 282 PQHISNMH 289 >UniRef50_A5IKF3 Methionine synthase (B12-dependent) n=6 Tax=Thermotogaceae RepID=A5IKF3_THEP1 Length = 768 Score = 284 bits (727), Expect = 3e-75, Method: Composition-based stats. Identities = 74/310 (23%), Positives = 118/310 (38%), Gaps = 27/310 (8%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M + LL + +LLLDGA TE G + ++ ++ P+++ +VH Y Sbjct: 1 MRNRREVSKLLS-ERVLLLDGAYGTEFMKYGYDD----LPEELNIKAPDVVLKVHRSYIE 55 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 +G+ +T ++ AT GL E + ++ +V +AR+A LV G Sbjct: 56 SGSDVILTNTFGATRMKLRKHGL-EDKLDPIVRNAVRIARRAAGEK----------LVFG 104 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 +GP G + E F R V+ +++ G D + ET + E++A Sbjct: 105 DIGPTGELPYPLG------NTLFEEFYENFRETVKIMVEEGVDGIIFETFSDILELKAAV 158 Query: 181 ELLTAYP-RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAA 238 T + GT + V ALGINC E Sbjct: 159 LAAREVSRDVFLIAHMTFDEKGRSLTGTDPANFAITFDEL-DVDALGINCSLGPEEILPI 217 Query: 239 LQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRT 298 Q L T LVV PN+G+ KT + A ++ + G + GGCC T Sbjct: 218 FQELSQYTDKFLVVEPNAGKPIVENGKTV--YPLKPHDFAVHIDSYYELGVNIFGGCCGT 275 Query: 299 TPADIAALKA 308 TP + + Sbjct: 276 TPEHVKLFRK 285 >UniRef50_C1F3L2 Methylenetetrahydrofolate reductase n=2 Tax=Bacteria RepID=C1F3L2_ACIC5 Length = 636 Score = 284 bits (726), Expect = 3e-75, Method: Composition-based stats. Identities = 89/307 (28%), Positives = 135/307 (43%), Gaps = 17/307 (5%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 NN L+ + + +L DGAM T L ARG + ++ + PEL+R VH DY +AG Sbjct: 1 MNNRLKEIFGDRPVLC-DGAMGTSLYARGIFINR--CFDELNLSQPELVRSVHEDYLQAG 57 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 A+ T ++ A GL + + + +AR A + QAG VAGSV Sbjct: 58 AEIIETNTFGANAIRLRRYGLQD-KVAEINQAGARIARAAVAQLADK--QAGNAWVAGSV 114 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G L + ++ QA ++E L+ G DLL ET+P +E + Sbjct: 115 GPLGVRLEPLGK------VGLDEAQAIFAEQIEGLVAGGVDLLVIETMPALNEAQQAIRA 168 Query: 183 LTA-YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQ 240 A P T+ + DGT A LAG+ A+G+NC A++ Sbjct: 169 ARAVAPELPVIAMVTVDEESRCLDGTAPEVAAARLAGW-GADAVGVNCSTGPAAVLTAIE 227 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 + T LPL PN+G + + +A + ++ +G + +GGCC TTP Sbjct: 228 CMAEATDLPLAAMPNAGMPRAVDGRNIYL--CSPEYMASFARKFHKSGVQFLGGCCGTTP 285 Query: 301 ADIAALK 307 I A+K Sbjct: 286 NHIRAMK 292 >UniRef50_Q5PNQ3 Novel protein containing a homocysteine S-methyltransferase domain (Fragment) n=4 Tax=Euteleostomi RepID=Q5PNQ3_DANRE Length = 318 Score = 284 bits (726), Expect = 4e-75, Method: Composition-based stats. Identities = 118/305 (38%), Positives = 175/305 (57%), Gaps = 15/305 (4%) Query: 15 DILLLDGAMATELEARGCNL-ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 +LDG +ATELEA G L D LWSA+VL +P+ I++VH Y ++G+ TA+YQA Sbjct: 11 SPFILDGGLATELEASGFQLQGDPLWSARVLHTDPQAIKDVHYRYLQSGSDVITTATYQA 70 Query: 74 TPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENP--QAGTLLVAGSVGPYGAYLA 130 + GF G+ +++ ++ +V+LA++ +++++P LVAGSVGPYG++L Sbjct: 71 SIEGFVKYLGVQPEEAQHMMMSAVQLAKETVSEFISQSPMSDRREPLVAGSVGPYGSFLH 130 Query: 131 DGSEYRGDYH--CSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPR 188 DGSEY G Y +VE + +HRP+++ L+ AGADL+A ET+P E EAL ++L +P Sbjct: 131 DGSEYTGAYEDKMTVEELKDWHRPQIQCLVKAGADLVAMETIPGLKEAEALVKVLKEFPE 190 Query: 189 ARAWFSFT----LRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHL-- 242 +AW SF+ +D+ +S G + V + Q+VA+G+NC L+ Sbjct: 191 TKAWLSFSSINLFQDNNSISSGRRFSEAVEMACRSTQLVAVGVNCCPALLVKPLLESAKS 250 Query: 243 HGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPAD 302 H L VVYPNSGE +D + A+ +W+A GA IGGCCR PAD Sbjct: 251 HKRADLSWVVYPNSGEGWDVTTGWKTEMRTS---FANLSLEWKAQGALWIGGCCRVRPAD 307 Query: 303 IAALK 307 I LK Sbjct: 308 ITELK 312 >UniRef50_A4XIN4 Homocysteine S-methyltransferase n=1 Tax=Caldicellulosiruptor saccharolyticus DSM 8903 RepID=A4XIN4_CALS8 Length = 411 Score = 283 bits (725), Expect = 4e-75, Method: Composition-based stats. Identities = 72/301 (23%), Positives = 125/301 (41%), Gaps = 26/301 (8%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 + +L+ DGAM T+L G + V PE+I ++H DY+ AG+ C T ++ A Sbjct: 8 KKVLVFDGAMGTQLIQNGLKENE--CPDLWSVTRPEVIAKIHRDYFEAGSDCVETNTFGA 65 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 GL E + + + ++ LA+ + Y V SVGP G + Sbjct: 66 NREKLKKYGL-ENEVEKINKAAILLAKDVAKEYGG--------YVGLSVGPTGRLMRPSG 116 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT-----AYPR 188 + + ++ ++ A ++AGAD ++ ET+ + E +A A Sbjct: 117 D------LDFDEAESVFYEQILAGIEAGADFISIETMSDIKEAKAAFLAYKRAKENANKD 170 Query: 189 ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTV 247 S T +++ L GTP +V A + +G NC + ++ ++G + Sbjct: 171 VACLVSLTFEENKRLLMGTPP-EVAAYFFSFIGADLVGANCSGGAKQLLDVIKSMNGFSF 229 Query: 248 LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 +PL PN+G K + + A ++ +G RL GGCC T P I A+ Sbjct: 230 VPLSTKPNAGLPKMIDGKVV--YEDCIADFESSTEEFIQSGVRLYGGCCGTNPEYIKAIA 287 Query: 308 A 308 Sbjct: 288 K 288 >UniRef50_C6JIG3 Methionine synthase n=3 Tax=Fusobacterium RepID=C6JIG3_FUSVA Length = 1112 Score = 283 bits (725), Expect = 4e-75, Method: Composition-based stats. Identities = 66/308 (21%), Positives = 124/308 (40%), Gaps = 21/308 (6%) Query: 13 KQDILLLDGAMATELEARGCNLADS----LWSAKVLVENPELIREVHLDYYRAGAQCAIT 68 K+ IL+LDGA T ++ + D + + + P++I+E+H Y +AGA T Sbjct: 6 KKRILVLDGATGTAIQKYNLSEIDFQGKKGCNEILNISRPDIIKEIHTGYIKAGADIIET 65 Query: 69 ASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 S+ G+ E S L K ELAR+ + + + VAGS+GP Sbjct: 66 NSFNCNRISLKDYGI-EDMSYTLSKKGAELAREIADNFYK--TSGKKIYVAGSIGPTSKS 122 Query: 129 LA-DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYP 187 L+ + + + + + + ++E ++D GAD + ET+ + +A Sbjct: 123 LSLPVGDNPYERELNFDQMKNIYSEQIEGVIDGGADCILIETIFDGLNAKAALIAAEELF 182 Query: 188 RA-----RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQH 241 S T+ + G + ++ L P +++ G+NC ++ ++ Sbjct: 183 EKKNIQLPIMISATVNKQGKIFSGQSIESLIVAL-DRPSIISFGLNCSFGAKDLIPMIKK 241 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG-ARLIGGCCRTTP 300 + T + +YPN+G + E YL + ++GGCC T Sbjct: 242 IAAFTDKYISLYPNAGLP-----NENGEYEETPEITTGYLKELVDKKQVNILGGCCGTHF 296 Query: 301 ADIAALKA 308 + I A+ Sbjct: 297 SHIKAIAD 304 >UniRef50_A3ERA3 5-methyltetrahydrofolate--homocysteine methyltransferase n=3 Tax=Leptospirillum RepID=A3ERA3_9BACT Length = 815 Score = 283 bits (724), Expect = 6e-75, Method: Composition-based stats. Identities = 82/308 (26%), Positives = 130/308 (42%), Gaps = 25/308 (8%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 PL L K +ILLLDG+M L++RG +E P+ I++VH +Y AG+ Sbjct: 2 KPLLERL-KNEILLLDGSMGALLQSRGLPPG--YAPDLWNLERPQDIQQVHSEYVEAGSD 58 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP 124 +T ++ ++ E Q + + VE+AR+A G VAG +GP Sbjct: 59 IILTNTFGSSRLRLREYD-AEGQIREINEAGVEMARRA---------SRGKAYVAGDIGP 108 Query: 125 YGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 G +A + + + LL+AG DL+A ET+ + E+ A + Sbjct: 109 SGTTIAPFGDLP------FDDAIGIFYEQARILLEAGVDLIAIETMFDIQEMRAALIGVR 162 Query: 185 AY--PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 R T + G+ ++L G+ V LG+NC + E ++ Sbjct: 163 EAVGNRIPVMALMTFNNDGITDSGSDPETAASVLEGF-GVEILGLNCSVGPEAMVPVVRR 221 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 L T + V PN+G T + + +A + PQ+ AGA +IGGCC TTP Sbjct: 222 LGQTTSTFIAVEPNAGLPVHRDGHTV--YPANAEDVARFAPQFVEAGANIIGGCCGTTPE 279 Query: 302 DIAALKAR 309 + L Sbjct: 280 YVRLLSRM 287 >UniRef50_C1XT53 Methionine synthase (B12-dependent) n=2 Tax=Meiothermus RepID=C1XT53_9DEIN Length = 1223 Score = 283 bits (724), Expect = 6e-75, Method: Composition-based stats. Identities = 69/307 (22%), Positives = 116/307 (37%), Gaps = 27/307 (8%) Query: 14 QDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREVHLDYYRAGAQCAI 67 + +L+ DGAM TE+ + AD + + P++I +H Y AGA Sbjct: 23 ERVLIYDGAMGTEIFKYDLSAADYGAEQYNGCPEMLNRTRPDVIEAIHKSYLEAGADVIE 82 Query: 68 TASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGA 127 T ++ A P GL EA++ L LAR+ + + VAGS+GP Sbjct: 83 TNTFGAFPHVLVEYGL-EAEAYELAFAGAHLARRVADEHSTP---DQPRFVAGSMGPGTK 138 Query: 128 YLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY- 186 ++ G S E +R + LLD G DL+ ET + ++ Sbjct: 139 LISLGQ-------ISWEGLFESYRVCAQGLLDGGVDLILIETCQDILQVRCAVLAARRAM 191 Query: 187 ----PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 T+ + + GT + +L P + +G NC + ++ Sbjct: 192 KDVGREVPIQVQVTMETTGTMLVGTDDAAALTVLEALP-IDVVGFNCATGPDLMDTHVRF 250 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ-AAGARLIGGCCRTTP 300 + PN+G + + + A+LA + ++ G ++GGCC T P Sbjct: 251 FCENATRWVSCLPNAGLPRNEGGRVV--YDLTPAELARWQQKFVNEYGLNVVGGCCGTGP 308 Query: 301 ADIAALK 307 I AL Sbjct: 309 EHIRALA 315 >UniRef50_C0ZBM1 5-methyltetrahydrofolate--homocysteine methyltransferase n=3 Tax=Bacillales RepID=C0ZBM1_BREBN Length = 1148 Score = 283 bits (724), Expect = 7e-75, Method: Composition-based stats. Identities = 75/319 (23%), Positives = 123/319 (38%), Gaps = 30/319 (9%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREVHL 56 R L ++ IL+LDGAM T L+ D + + + P++IR +H Sbjct: 1 MKPTFREQLSRK-ILILDGAMGTMLQQANLTADDFGGEAYDGCNELLNLTRPDVIRSIHE 59 Query: 57 DYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTL 116 Y AGA T ++ A A + E + + LAR+A +AY E Sbjct: 60 KYLEAGADIVETNTFGAASIVLAEYDVAEKDL-EINIAAARLAREAVDAYSTEEW---PR 115 Query: 117 LVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEI 176 VAG++GP L+ + E + + + L+ G+D+L ET + + Sbjct: 116 FVAGAMGPTTKTLSLTG------GVTFEELVEAYYRQAKGLILGGSDVLLLETSQDTLNV 169 Query: 177 EA----LAELLTAYP-RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-I 230 +A + + S T+ G + L + + V++G+NC Sbjct: 170 KAGGIGIRKAFEELGQEIPVMLSGTIEPMGTTLAGQNIEAFYISLE-HIKPVSIGLNCAT 228 Query: 231 ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG-A 289 E L+ L G+ + YPN+G D + E LA + + G Sbjct: 229 GPEFMRDHLRTLSGIAQCAVSCYPNAGLP-DENGH----YHETPQGLASKMRAFAEQGWI 283 Query: 290 RLIGGCCRTTPADIAALKA 308 + GGCC TTP I A+ Sbjct: 284 NVAGGCCGTTPDHIQAMAE 302 >UniRef50_Q5E814 Methionine synthase n=458 Tax=Bacteria RepID=METH_VIBF1 Length = 1226 Score = 282 bits (722), Expect = 1e-74, Method: Composition-based stats. Identities = 67/317 (21%), Positives = 132/317 (41%), Gaps = 31/317 (9%) Query: 14 QDILLLDGAMATELEARGCNLAD------SLW-------SAKVLVENPELIREVHLDYYR 60 + ILL+DG M T ++ D + W + +++ P++IR++H Y Sbjct: 16 ERILLIDGGMGTMIQGYKFEEEDYRGERFNKWHCDLKGNNDLLVLSQPQIIRDIHEAYLE 75 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGA T ++ AT A + E+ S+ + ++ +LAR+ + + + P VAG Sbjct: 76 AGADILETNTFNATTIAMADYDM-ESLSEEINFEAAKLAREVADKWTEKTPN-KPRYVAG 133 Query: 121 SVGPYGAY--LADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 +GP ++ G + S + + AL+ G+DL+ ET+ + +A Sbjct: 134 VLGPTNRTCSISPDVNDPGFRNVSFDELVEAYSESTRALIRGGSDLILIETIFDTLNAKA 193 Query: 179 LAELLTAYPR-----ARAWFSFTLRD-SEHLSDGTPLRDVVALLAGYPQVVALGINCI-A 231 + + + S T+ D S G + + + ++ G+NC Sbjct: 194 CSFAVESVFEELDITLPVMISGTITDASGRTLSGQT-TEAFYNALRHVKPISFGLNCALG 252 Query: 232 LENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG-AR 290 + + L ++ + +PN+G + + +A+++ +W ++G Sbjct: 253 PDELREYVSDLSRISECYVSAHPNAGLP-----NAFGEYDLSPEDMAEHVAEWASSGFLN 307 Query: 291 LIGGCCRTTPADIAALK 307 LIGGCC TTP I + Sbjct: 308 LIGGCCGTTPEHIRQMA 324 >UniRef50_B8I366 Homocysteine S-methyltransferase n=1 Tax=Clostridium cellulolyticum H10 RepID=B8I366_CLOCE Length = 434 Score = 282 bits (721), Expect = 1e-74, Method: Composition-based stats. Identities = 64/297 (21%), Positives = 115/297 (38%), Gaps = 23/297 (7%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 ++ +L+ DG+M L+++G + + + +PE+++E++ Y AGA + ++Q Sbjct: 8 EKKVLVFDGSMGIMLQSKGLEVGT--CPEEWNITHPEMVKEIYTAYRDAGANVIQSNTFQ 65 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 + + GL + + V LA++ VA S+GP G L Sbjct: 66 SNLMKLSEYGLQDKH-YDINFAGVSLAKEVM---------GDKGYVAASIGPLGKLLEPF 115 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 E + E + +V A+ GAD+++ ET + SE+ Sbjct: 116 GE------LTFEQAYNTFKEQVVAVTAGGADIISFETFTDVSEMRIALLASKENCNLPVI 169 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLV 251 S + + G+ +L +G NC E + T L Sbjct: 170 CSISYEQNGRTLMGSDPAVCACILHSL-GADMIGTNCSFGPEYMIKVAESYGK-TGLKFS 227 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 + PN+G + E + A+Y ++ GARL+GGCC T P IA + Sbjct: 228 IKPNAGIPKTVDGNLV--YDETPEKFAEYAQEFIKYGARLVGGCCGTRPEFIAEISK 282 >UniRef50_A9B073 Methionine synthase n=2 Tax=Bacteria RepID=A9B073_HERA2 Length = 1180 Score = 282 bits (721), Expect = 1e-74, Method: Composition-based stats. Identities = 82/320 (25%), Positives = 138/320 (43%), Gaps = 22/320 (6%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADS----LWSAK--VLVENPELIREV 54 M+ P A L K +L+ DGAM T L+ D + A+ + + P++I ++ Sbjct: 1 MTSIKPYIAELAK-RVLIYDGAMGTSLDLYDLKPEDFGGEQYFGARDYLALTRPDIIEQI 59 Query: 55 HLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAG 114 H + AG T ++Q+T GL + + K+ +LARK + Y + Sbjct: 60 HSSFMEAGVDVLETNTFQSTRIRLHEWGLADKTYEQ-NFKAAQLARKVADRY--QAQDGR 116 Query: 115 TLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFS 174 VAGS+GP G S+ + + +A + + AL++ G D+L ET + Sbjct: 117 KRFVAGSMGPTGFL--PSSDDPTLSNITWDALSDTFKEQTIALVEGGVDVLLVETSVDIL 174 Query: 175 EIEALAELLT------AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGIN 228 E++A + + P L S + GT ++ + L V +G+N Sbjct: 175 EVKAAIDGIRRGLAELKRPDIAIQAQVFLDLSGRMLLGTDIQATMVTLEALADVDVIGLN 234 Query: 229 C-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ-A 286 C E+ A+ +L + LP+ PN+G + +T A A L ++ Sbjct: 235 CSTGPEHMRPAITYLAANSKLPISCIPNAGLPMEVNGETV--FPLEPAGFAKSLTEFVQD 292 Query: 287 AGARLIGGCCRTTPADIAAL 306 G R++GGCC TTPA + AL Sbjct: 293 LGVRVVGGCCGTTPAHLRAL 312 >UniRef50_UPI00017B4C9F UPI00017B4C9F related cluster n=1 Tax=Tetraodon nigroviridis RepID=UPI00017B4C9F Length = 1141 Score = 281 bits (720), Expect = 2e-74, Method: Composition-based stats. Identities = 76/327 (23%), Positives = 135/327 (41%), Gaps = 29/327 (8%) Query: 5 NPLRALLDKQDILLLDGAMATELEA--------RGCNLAD---SLW--SAKVLVENPELI 51 P + ++ I++LDG M T ++ RG D L + + + P+++ Sbjct: 16 EPELRGILERRIMILDGGMGTMIQQHKLEECNFRGDEFKDHPQPLMGNNDLLSLTCPDIV 75 Query: 52 REVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENP 111 ++H DY AGA T ++ T A GL E + L S ELARKA + + Sbjct: 76 YKIHKDYLLAGADIIETNTFSGTSVAQADYGL-EHMAYRLNKASAELARKAADDVT--SS 132 Query: 112 QAGTLLVAGSVGPYGAYLA--DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACET 169 VAG++GP L+ E + + +A + +V+ LLD G D+L ET Sbjct: 133 TGVKRYVAGALGPTNKTLSVSPSVEKPHFRNITFDALVEAYTEQVKGLLDGGVDILLVET 192 Query: 170 LPNFSEIEALAELL-----TAYPRARAWFSFT-LRDSEHLSDGTPLRDVVALLAGYPQVV 223 + + + +A + +Y R + S T + S G + V + + + + Sbjct: 193 IFDTANAKAALFAIDLLFEKSYSRKPIFISGTVVDRSGRTLSGQTVEAFVVSV-SHAKPL 251 Query: 224 ALGINCI-ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLP 282 +G+NC ++ + T ++ YPN+G + + ++ Sbjct: 252 CIGLNCALGATEMRPFIEAIGKCTTAFVICYPNAGNPHLF--NQYLSDTVRPTHISFNAK 309 Query: 283 QWQAAG-ARLIGGCCRTTPADIAALKA 308 ++ G ++GGCC TTP I AL Sbjct: 310 EFSVDGLVNIVGGCCGTTPEHIRALCE 336 >UniRef50_A9KSG0 Homocysteine S-methyltransferase n=7 Tax=Clostridiales RepID=A9KSG0_CLOPH Length = 841 Score = 280 bits (717), Expect = 4e-74, Method: Composition-based stats. Identities = 65/309 (21%), Positives = 130/309 (42%), Gaps = 15/309 (4%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M++N +A+++++ I++LDGA + L+ G + +++N E++ + +Y Sbjct: 1 MTKNE-FKAMIEQK-IVILDGATGSNLQNAGMPSG--VCPETWILDNKEVLITLQKEYLY 56 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AG ++ + + GL E + + + VEL+++A YL E + ++++AG Sbjct: 57 AGTDILYAPTFTSNRIKLSEYGL-EHRIEEINHSLVELSKEAINRYLEETGETRSIMIAG 115 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 + G L + E ++ ++ L+ +G DLL ET+ + E A Sbjct: 116 DLTMTGEQLLPFGK------MDFEELITIYKEQIGHLVSSGVDLLVVETMLSLQECRAAV 169 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAAL 239 S T + GT + + +L A+G+NC + + + Sbjct: 170 IAAKEICELPVMVSLTFGEDNRTLYGTDPKTAMIVLQSL-GADAVGVNCSSGPKKLSEVI 228 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 + + + +PL+ PN+G +T + A + G ++GGCC TT Sbjct: 229 EQMLPVANVPLIAKPNAGLPKLVEDRTVFTMD--ADEFAASCKIFLELGVSILGGCCGTT 286 Query: 300 PADIAALKA 308 P I L Sbjct: 287 PKHINLLNE 295 >UniRef50_Q01QP4 Methylenetetrahydrofolate reductase n=2 Tax=Acidobacteria RepID=Q01QP4_SOLUE Length = 622 Score = 280 bits (716), Expect = 5e-74, Method: Composition-based stats. Identities = 80/312 (25%), Positives = 136/312 (43%), Gaps = 25/312 (8%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRA 61 S+ R L + +++ DGAM T L +RG + ++ + +++R++H +Y +A Sbjct: 7 SRAQEFRDQLAR-RVIVADGAMGTMLYSRGVFINR--CFDELNLSAADMVRQIHQEYVKA 63 Query: 62 GAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGS 121 GA+ T ++ AT A G E + +A+ V LAR+A G+ VAG+ Sbjct: 64 GAEILETNTFGATRQRLGAFGFAE-KLQAINHAGVRLAREAAN---------GSAYVAGA 113 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 VGP + S +A R +++ALL+AG DLL ET N E+ Sbjct: 114 VGPLNVRIEPLG------PTSFAEARAAFREQIDALLEAGVDLLIFETFGNLDELREAVY 167 Query: 182 LL--TAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAA 238 + T+ D HL GT + +P V +G+NC + + T Sbjct: 168 AGYDASRGEVPMIAQVTIDDFGHLPGGTDTETFTREMNNWP-VDVIGLNCSVGPKATLET 226 Query: 239 LQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRT 298 ++ + PL PN+G + + ++ Y + AG ++IGGCC T Sbjct: 227 VERMMEFATKPLSAMPNAGLPMRVEGRNIYL--CSPEYMSQYARRLLWAGVKVIGGCCGT 284 Query: 299 TPADIAALKARS 310 TP I +++ + Sbjct: 285 TPDHIKLIRSET 296 >UniRef50_B6YR37 Cobalamin-dependent methionine synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YR37_AZOPC Length = 1224 Score = 280 bits (716), Expect = 5e-74, Method: Composition-based stats. Identities = 76/327 (23%), Positives = 135/327 (41%), Gaps = 32/327 (9%) Query: 5 NPLRALLDKQDILLLDGAMATELEA--------RGCNLAD-----SLWSAKVLVENPELI 51 N + LL ++ ILLLDG M + ++ RG A S + + P++I Sbjct: 2 NSISQLL-QERILLLDGGMGSMIQNYRLKETDYRGLQFAHLSGEMYGNSDILCITRPDII 60 Query: 52 REVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENP 111 + +H Y AGA T S T A G+ E+ ++L + +A++ + Y P Sbjct: 61 QSIHEAYLEAGADIIETNSMNMTAISMADYGI-ESHVESLNKAAATIAKEVAQKYTKLTP 119 Query: 112 QAGTLLVAGSVGPYGAY--LADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACET 169 VAGS+GP L+ G + + + ++ AL+ G D+L ET Sbjct: 120 D-KPRFVAGSIGPTNKTSSLSPDVNNPGYRNITFTELYKAYCEQIAALIFGGVDILLVET 178 Query: 170 LPNFSEIEALAELLT-----AYPRARAWFSFTLR-DSEHLSDGTPLRDVVALLAGYPQVV 223 + ++A A S+TL +S + G L V+ + + ++ Sbjct: 179 AFDTLNVKAALMAAEDEMKIAKKELPLMLSYTLSGNSGRILSGQTLEAVLESI-SHINLL 237 Query: 224 ALGINCI-ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLP 282 ++G+NC L+ L + + YPN+G + + E +A+ + Sbjct: 238 SIGLNCSFGARTMKPFLKKLGQIAPCYVSAYPNAGLP-----NAFGKYNETPEMMAEQIR 292 Query: 283 QWQ-AAGARLIGGCCRTTPADIAALKA 308 ++ + ++GGCC TTP IAA+ Sbjct: 293 EYIDESLVNIVGGCCGTTPQHIAAIAR 319 >UniRef50_B9MN08 Homocysteine S-methyltransferase n=1 Tax=Anaerocellum thermophilum DSM 6725 RepID=B9MN08_ANATD Length = 413 Score = 280 bits (716), Expect = 5e-74, Method: Composition-based stats. Identities = 67/301 (22%), Positives = 119/301 (39%), Gaps = 26/301 (8%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 + +L+ DGAM T+L G + V +++ +H Y+ AG+ C T ++ A Sbjct: 10 RRVLIFDGAMGTQLIQNGLTEDE--CPDLWSVTRQDVVSSIHRQYFEAGSDCVETNTFGA 67 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 GL E + + + +V+LA++ + Y V SVGP G Sbjct: 68 NREKLKKYGL-ENEVENINKCAVKLAKEVAKEYSG--------YVGLSVGPTGRLFIPSG 118 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY-----PR 188 + S + ++ ++ + ++AGAD ++ ET+ + E +A Sbjct: 119 D------LSFDEAESIFYEQILSGIEAGADFVSIETMSDIKEAKAAFFAYKKAKEELKKD 172 Query: 189 ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALE-NTTAALQHLHGLTV 247 S T ++ L GTP +V A +G NC ++ + + Sbjct: 173 IPCLISLTFEQNKRLLMGTPP-EVAAYYFSSIGCDIVGANCSGGAIQLLEIIKQMQFFSF 231 Query: 248 LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 +PL V PN+G KT + + + ++ G RL GGCC T P I ++ Sbjct: 232 VPLSVKPNAGLPKVVDGKTI--YESCIPEFVNLADEFVENGVRLYGGCCGTNPEYIKSIS 289 Query: 308 A 308 Sbjct: 290 K 290 >UniRef50_B3E428 Methionine synthase n=91 Tax=Bacteria RepID=B3E428_GEOLS Length = 1169 Score = 280 bits (716), Expect = 6e-74, Method: Composition-based stats. Identities = 95/326 (29%), Positives = 143/326 (43%), Gaps = 33/326 (10%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREV 54 M+ N L+AL Q IL+LDGAM T+L+AR AD + +++ P++I +V Sbjct: 1 MTNNPVLQAL--SQCILILDGAMGTQLQARNLTAADFGGEAYEGCNEMLVLTRPDVIEDV 58 Query: 55 HLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAG 114 H Y AGA T S+ +T A GL + + L + +ARKA +AY Sbjct: 59 HKAYLEAGADIVETCSFGSTDIVLAEYGLAD-KVFELNKAAALVARKACDAYSTP---DK 114 Query: 115 TLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFS 174 VAGS+GP ++ + E R + LL G DLL ET + Sbjct: 115 PRFVAGSMGPTTRTISVTG------GVTFEQLVTAFRDQTIGLLAGGVDLLLLETAQDTL 168 Query: 175 EIEALAELLT-----AYPRARAWFSFTLRDSEHLSDGTPLRDVVAL---LAGYPQVVALG 226 ++A AE + R S T+ + + G + + A L ++++G Sbjct: 169 NLKAGAEGIRLAFEQTGQRVPLMVSGTIEPTGTMLAGQNVEALYASLTHLEENLGLISIG 228 Query: 227 INC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ 285 +NC E T L+ L L + VYPN+G D + E LA L ++ Sbjct: 229 LNCATGPEFMTDHLRALSELATCHISVYPNAGLP-DENGN----YAESPDSLAQKLSRFV 283 Query: 286 AAG-ARLIGGCCRTTPADIAALKARS 310 G +IGGCC T+PA IAA+ + Sbjct: 284 DEGWLNIIGGCCGTSPAHIAAIANMA 309 >UniRef50_C6HW85 5-methyltetrahydrofolate--homocysteine methyltransferase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HW85_9BACT Length = 822 Score = 279 bits (715), Expect = 7e-74, Method: Composition-based stats. Identities = 85/305 (27%), Positives = 135/305 (44%), Gaps = 24/305 (7%) Query: 6 PLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQC 65 PL L K+DIL+LDG+M L+ RG +E P+ I+ VH +Y AG+ Sbjct: 3 PLLERL-KKDILILDGSMGALLQGRGLPPG--YAPDLWNLERPKDIQAVHAEYRAAGSDI 59 Query: 66 AITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY 125 +T ++ A+ A E + + + VELAR+A + G +AG +GP+ Sbjct: 60 LLTNTFGASRRRLAEY-QAEGRIREINHAGVELARRAAQ---------GKAYIAGDIGPF 109 Query: 126 GAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA 185 G+ +A + + E R + L +AG DL+A ET+ + E+ A + Sbjct: 110 GSTIAPFGD------TTFEEAVGIFREQASILAEAGVDLIAIETMFDIQEMRAALIGVRE 163 Query: 186 -YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLH 243 P T G+ V A+L G+ V +G+NC + E L+ L Sbjct: 164 GAPGVPIMAFMTYNADGITDSGSDPETVAAVLEGFS-VEIMGLNCSVGPEAMLPVLERLG 222 Query: 244 GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADI 303 T L + PN+G KT + +++A + P + AGA ++GGCC TTP I Sbjct: 223 RATHTYLGIEPNAGLPVHRDGKTV--YPLGASEMASFAPAFADAGANIVGGCCGTTPDYI 280 Query: 304 AALKA 308 + Sbjct: 281 RLISK 285 >UniRef50_C0QRY9 Methionine synthase n=3 Tax=Bacteria RepID=C0QRY9_PERMH Length = 1182 Score = 279 bits (714), Expect = 8e-74, Method: Composition-based stats. Identities = 71/315 (22%), Positives = 134/315 (42%), Gaps = 26/315 (8%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNL----ADSLWSAKVLVENPELIREVHLDYYR 60 +R L+ K+ +L++DGAM T +++ + + + + V P++IR +H Y Sbjct: 2 KSIRDLIGKK-VLVIDGAMGTMIQSMIIPMEAWEGKTGCNEILNVTAPDVIRSIHEKYAL 60 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGA T ++ A P G+ + ++ L EL R+ + Y VAG Sbjct: 61 AGADLIKTNTFGALPWVLEEYGISD-RAYELSKAGAELVRQVCDKYSTP---EKPRFVAG 116 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 S+GP G++ H + +R + L+D G D+ ET + +I+A Sbjct: 117 SLGP-------GTKLPSLGHIDYDEMYEGYRISAKGLIDGGVDIFLLETFQDPLQIKAAL 169 Query: 181 ELLTA-----YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALEN 234 + S T+ + + GT ++ + ++ + ++ LG NC + Sbjct: 170 HAVQDTAEEYGKDIPVMVSATIELTGTMLIGTDVQTLAVIMEPF-DILTLGFNCGTGPDQ 228 Query: 235 TTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQA-AGARLIG 293 + L+ L + + ++ N+G + T+ + + AD ++ G ++G Sbjct: 229 IESHLKKLSQVWDGYISIHSNAGLPENRGGHTY--YPMGAEEFADKESRFLDFDGVAVVG 286 Query: 294 GCCRTTPADIAALKA 308 GCC TTPA I AL Sbjct: 287 GCCGTTPAHIKALAE 301 >UniRef50_Q1GBT8 Homocysteine S-methyltransferase n=2 Tax=Lactobacillus delbrueckii subsp. bulgaricus RepID=Q1GBT8_LACDA Length = 310 Score = 279 bits (714), Expect = 9e-74, Method: Composition-based stats. Identities = 138/299 (46%), Positives = 179/299 (59%), Gaps = 5/299 (1%) Query: 11 LDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITAS 70 L Q + LDG+M+T LEA G + LW+AK L +NP+L+ VH +Y++AGA+ IT S Sbjct: 7 LLAQGPVTLDGSMSTPLEAWGEDTNSDLWTAKALADNPDLVYRVHQEYFKAGARVTITDS 66 Query: 71 YQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLA 130 YQA+ F GL E ++ALI +S +A KAR+ + E VAGSVGPYGAYLA Sbjct: 67 YQASLPAFMKHGLSEDAARALIRESAAVAIKARDDFEKE--TGIHNFVAGSVGPYGAYLA 124 Query: 131 DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA-YPRA 189 DGSEYRGDY S E + FH PR+E L+ G D LA ET P SE+ A+ + L A YP Sbjct: 125 DGSEYRGDYALSHEEYVDFHAPRIEELVAGGVDCLAVETQPKLSEVRAILDYLKAKYPDL 184 Query: 190 RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLP 249 + SF+L+D +S+G PL + V ++ Y QV A G NC L T +++L + LP Sbjct: 185 PVYVSFSLKDPATISEGLPLTEAVEEVSAYAQVFAAGANCFKLAWTVDVVKNLRA-SKLP 243 Query: 250 LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 +VVYPNSG YD K W + A W AAGA+L+GGCC T P DIA L A Sbjct: 244 IVVYPNSGAEYDPSVKKW-VYPPEAADFGQAGAAWLAAGAKLVGGCCTTMPEDIAGLAA 301 >UniRef50_C6W4B8 Methionine synthase n=4 Tax=Bacteria RepID=C6W4B8_DYAFD Length = 1274 Score = 279 bits (713), Expect = 1e-73, Method: Composition-based stats. Identities = 81/347 (23%), Positives = 135/347 (38%), Gaps = 51/347 (14%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEA--------RGCNLADSLWS-------AKVLVE 46 +Q +R +L K IL+LDGAM T ++ RG AD W + + Sbjct: 4 TQKADIREIL-KNRILVLDGAMGTMIQRYKLQDHDYRGERFAD--WPHDVKGNNDLLSLT 60 Query: 47 NPELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAY 106 P++I+E+H Y+ AGA A T ++ T A G+ E L +S LAR+ + + Sbjct: 61 RPDIIKEIHAAYFAAGADIAETNTFSGTTIAMADYGM-EEIVYELNYESARLAREVADEF 119 Query: 107 LAENPQAGTLLVAGSVGPYG--AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADL 164 P VAGS+GP A L+ G S + + +V+ L D G DL Sbjct: 120 TEREP-HKPRFVAGSIGPTNRTASLSPDVNNPGFRAISFDQLVEAYYEQVKGLTDGGCDL 178 Query: 165 LACETLPNFSEIEALAELLTAY--------------------PRARAWFSFTLRD-SEHL 203 L ET+ + +A + + S T+ D S Sbjct: 179 LLVETIFDTLNAKAALFAIDQFFADAKAGKVEHLESWRIEPGQALPIMISGTITDASGRT 238 Query: 204 SDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLVVYPNSGEHYDA 262 G + ++ P ++++G+NC + +Q + + +PN+G + Sbjct: 239 LSGQTTEAFLTSVSHLP-LLSVGLNCALGADLMRPYVQIMAKESPFYTSAHPNAGLPNEM 297 Query: 263 VSKTWHHHGEHCAQLADYLPQWQAAG-ARLIGGCCRTTPADIAALKA 308 + E Q+ + + + +IGGCC TTP I + Sbjct: 298 G-----EYDETPEQMGEVIDGFLRDNLVNIIGGCCGTTPDHIRVIAE 339 >UniRef50_Q67LG1 5-methyltetrahydrofolate S-homocysteine methyltransferase n=2 Tax=Clostridiales RepID=Q67LG1_SYMTH Length = 859 Score = 279 bits (713), Expect = 1e-73, Method: Composition-based stats. Identities = 83/304 (27%), Positives = 125/304 (41%), Gaps = 23/304 (7%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 L +L ++ +L+ DGAM T L+A+G A +E PE + VH Y AGAQ Sbjct: 3 LEDMLGRE-VLVFDGAMGTMLQAQGL--APGACPDVWNLERPEDVIAVHRAYVEAGAQIL 59 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 T ++ +TP GL + + + ++ V AR+A G VAGS+GP G Sbjct: 60 ETNTFGSTPIRLGHYGLQD-RCRDIVVAGVRCAREAAA---------GRAWVAGSMGPLG 109 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA- 185 A + E + A + A +A D + ET+ + +E+ A Sbjct: 110 ALVEPLGELP------FDEAYAQFAVQARAFAEAQPDFIIIETIADLNELRAAVLACRDH 163 Query: 186 YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHG 244 P R TL S GT +L +G NC + + A+ + Sbjct: 164 APGIRIIAQITLDPSGRAFTGTDPETAALVLQSL-GADVIGFNCSVGPDLLVEAVARMAR 222 Query: 245 LTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 + +P+ V PN+G + A Y P+ AGA L+GGCC TTP I Sbjct: 223 VARVPISVQPNAGLPLLQPDGA-TRFPMGPEEFAAYGPKLVEAGAALVGGCCGTTPEHIR 281 Query: 305 ALKA 308 L+A Sbjct: 282 RLRA 285 >UniRef50_B3QGP3 Methionine synthase n=71 Tax=cellular organisms RepID=B3QGP3_RHOPT Length = 1293 Score = 279 bits (713), Expect = 1e-73, Method: Composition-based stats. Identities = 76/321 (23%), Positives = 130/321 (40%), Gaps = 32/321 (9%) Query: 11 LDKQDILLLDGAMATELEA--------RGCNLADSLW-----SAKVLVENPELIREVHLD 57 L Q IL+LDGAM T ++ RG D + +++ P+ I ++H Sbjct: 15 LAAQRILVLDGAMGTMIQQLQLDEAAFRGERFKDFHRDLRGNNDLLILTQPQAIEDIHAQ 74 Query: 58 YYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLL 117 Y RAGA T ++ +T A + E + + LAR A AE Sbjct: 75 YLRAGADIVATNTFSSTSIAQADYDMSE-LAYEMSRDGARLARNAAAKVEAE--DGKPRF 131 Query: 118 VAGSVGPYG--AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE 175 VAG++GP A ++ G + + + + ++ LLD GAD+L ET+ + Sbjct: 132 VAGAIGPTNRTASISPDVANPGYRAVTFDDLRIAYSEQINGLLDGGADILLLETIFDTLN 191 Query: 176 IEALAELLTAYP-----RARAWFSFTLRD-SEHLSDGTPLRDVVALLAGYPQVVALGINC 229 +A + S T+ D S L G + + + + + +G NC Sbjct: 192 AKAALYAIAEITEARGIDVPVMISGTITDKSGRLLSGQ-MPEAFWNSVRHARPITIGFNC 250 Query: 230 I-ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG 288 ++ A + + + + YPN+G + + E +A + ++ AG Sbjct: 251 ALGAKDLRAHIADISRVADTLVCAYPNAGLP-----NEFGQYDESPEYMASLVGEFAEAG 305 Query: 289 -ARLIGGCCRTTPADIAALKA 308 ++GGCC TTPA I A+ Sbjct: 306 LVNIVGGCCGTTPAHIKAIAE 326 >UniRef50_UPI0000DB6B54 PREDICTED: similar to CG10621-PA n=3 Tax=Apocrita RepID=UPI0000DB6B54 Length = 320 Score = 279 bits (713), Expect = 1e-73, Method: Composition-based stats. Identities = 113/313 (36%), Positives = 174/313 (55%), Gaps = 18/313 (5%) Query: 14 QDILLLDGAMATELEARGCNL--ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 Q++++LDG +T+L + D LW+A+ LV NP I HLD+ +AGA +T +Y Sbjct: 2 QEVMVLDGGFSTQLATHVDDTIDGDPLWTARFLVTNPNAIISTHLDFLKAGADIILTNTY 61 Query: 72 QATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQAGTL-----LVAGSVGPY 125 QA+ GF+ + E +S + K+V+ A++A Y + G + L+AGS+GPY Sbjct: 62 QASIDGFSKYMNITEEESLDIFSKAVDYAKEAVNLYKKDIENKGNVINANPLIAGSIGPY 121 Query: 126 GAYLADGSEYRGDY--HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 GA L D SEY G Y + + E +HRPR++ L+D G +LA ET+P E EAL +LL Sbjct: 122 GACLHDASEYSGKYCSNVTEEFLINWHRPRIQKLIDNGVHILAIETIPCKQEAEALIKLL 181 Query: 184 TAYPRARAWFSFTLRDSEH-LSDGTPLRDVVALLAGYP---QVVALGINCIALENTTAAL 239 +P ++AW SF+ + ++DGT + + Q++A+G+NC A +N T L Sbjct: 182 KEFPNSKAWLSFSCCNDGKSIADGTNFQQIAMQCYREALPKQILAIGVNCTAPQNVTKLL 241 Query: 240 QHLHGLTV---LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCC 296 + ++ +PLVVYPNSGE Y + W E L +++ +W G R IGGCC Sbjct: 242 KGINENNKQEFVPLVVYPNSGEKY-TIENGWTIKDEEECSLHEFIYEWLTLGVRYIGGCC 300 Query: 297 RTTPADIAALKAR 309 RT DI +++ Sbjct: 301 RTNATDIKKIRSE 313 >UniRef50_C6DY72 Homocysteine S-methyltransferase n=10 Tax=Desulfuromonadales RepID=C6DY72_GEOSM Length = 813 Score = 278 bits (712), Expect = 1e-73, Method: Composition-based stats. Identities = 80/298 (26%), Positives = 125/298 (41%), Gaps = 23/298 (7%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K+ +L+LDGAM T L+ RG S ++ + E++ VH Y AGA +T ++ Sbjct: 10 KERVLVLDGAMGTMLQERGLKPGQS--PEEMNLTAAEVVAGVHQAYLDAGADIIVTNTFG 67 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 T A GL + Q + ++V +AR+ VAGS+GP G +L Sbjct: 68 GTKAKLEHYGLGD-QVARINAEAVRIAREVA---------GEKAYVAGSIGPTGRFLEPV 117 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYP-RARA 191 + S + + R + +AL+DAG DL++ ET + EI A + Sbjct: 118 GD------MSFDEAVSLFREQAQALVDAGCDLISFETFLDIKEIRAGVIAVREISQEIPV 171 Query: 192 WFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPL 250 T + GTP + L +G NC + + L + +T LPL Sbjct: 172 IAMLTFEEKGISVLGTPPQAAAITLEAV-GATIVGSNCGLGPDGIYQILSDMRDVTALPL 230 Query: 251 VVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 + N+G ++ Y + G R+IGGCC TTPA I+A+K Sbjct: 231 ISQANAGLPILKDG--VTIFPATPDEMTAYHDRLIELGVRIIGGCCGTTPAHISAIKK 286 >UniRef50_B5YB64 5-methyltetrahydrofolate-homocysteine methyltransferase n=1 Tax=Dictyoglomus thermophilum H-6-12 RepID=B5YB64_DICT6 Length = 289 Score = 278 bits (712), Expect = 1e-73, Method: Composition-based stats. Identities = 76/312 (24%), Positives = 122/312 (39%), Gaps = 32/312 (10%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M++ L L DGAM TEL+ RG + +ENP L+ EVH DY + Sbjct: 1 MNRKIKLPEFL------FFDGAMGTELQRRGLPPGTP--PEVLNLENPTLVEEVHRDYIK 52 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AG+ T ++ GL + + K + K VE+A+KA G +L+AG Sbjct: 53 AGSMVIETNTFGGNRIRLKRAGL-DGKIKEINEKGVEIAKKA---------SEGKVLIAG 102 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 SVGP G + + S E + ++E L+ +G DL+ ET+ + +E Sbjct: 103 SVGPLGELIEPYGD------ISEEEAEEVFTEQIEILVKSGVDLILIETMISLNEALIAL 156 Query: 181 ELLTAYPRARAWFSFTL---RDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTT 236 + + + + G + + L +G NC E+ Sbjct: 157 KSAKKF-DIPVGVTMSFEWTERGGRTPFGDEVEYSIKTLEE-NGADFVGANCGRGFEDMI 214 Query: 237 AALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCC 296 + T LP+++ PN+G K + E + ++ + IGGCC Sbjct: 215 KIAPIIRKATTLPVLIQPNAGIPQWENGKL--TYPETPDKFKIFVEEMLKLNINFIGGCC 272 Query: 297 RTTPADIAALKA 308 TTP I K Sbjct: 273 GTTPNHIEVFKE 284 >UniRef50_Q7M929 S-METHYLTRANSFERASE n=1 Tax=Wolinella succinogenes RepID=Q7M929_WOLSU Length = 1120 Score = 277 bits (710), Expect = 2e-73, Method: Composition-based stats. Identities = 70/316 (22%), Positives = 130/316 (41%), Gaps = 25/316 (7%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLAD----SLWSAKVLVENPELIREVHL 56 M + +Q +++LDGAM TE++ D + S + V ++I +H Sbjct: 1 MKMEQFFE--IHRQRVMILDGAMGTEIQKFDLKEEDWEEKAGCSEILNVTRGDVILSIHR 58 Query: 57 DYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTL 116 Y AGA + ++ A P G+ ++ + ++A++A +++ Sbjct: 59 SYLEAGADILKSNTFGALPWVLEEYGIG-GRAYEMAFAGAQIAKEACDSFAPS-----PR 112 Query: 117 LVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEI 176 VAGS+GP G++ H + ++ L + GADL ET + +I Sbjct: 113 FVAGSLGP-------GTKLPSLGHIDYDTMFEGYKEAARGLKEGGADLFLLETCQDPLQI 165 Query: 177 EALAELLTAY-PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALEN 234 +A S T+ + + GT ++ + +L ++ +LGINC + + Sbjct: 166 KAAVHACKEVDSSMPIMVSATIETTGTMLIGTDIKTLAVILEPL-EIFSLGINCGLGPDM 224 Query: 235 TTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQA-AGARLIG 293 L+ L PL ++ N+G + T+ + + A+ ++ G +G Sbjct: 225 AEKHLKALAQYAPFPLSIHANAGLPQNVGGCTF--YPMEPKEFAEIEEEFLGIEGVAFLG 282 Query: 294 GCCRTTPADIAALKAR 309 GCC TTP I LK R Sbjct: 283 GCCGTTPEHIRQLKER 298 >UniRef50_Q2F5Q8 Homocysteine S-methyltransferase n=3 Tax=Endopterygota RepID=Q2F5Q8_BOMMO Length = 325 Score = 277 bits (709), Expect = 3e-73, Method: Composition-based stats. Identities = 112/312 (35%), Positives = 168/312 (53%), Gaps = 15/312 (4%) Query: 12 DKQDILLLDGAMATELEARGCNL--ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITA 69 + + +LDG +T+L + D L SA+ L +P+ + HLD+ RAG+ T Sbjct: 7 SSKTVFVLDGGFSTQLTCHAGHTADGDPLGSARFLKTHPQDVINTHLDFLRAGSDIIETN 66 Query: 70 SYQATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAE----NPQAGTLLVAGSVGP 124 +YQA+ G L +S LI +VE AR AR+ YL E N L+AGSVGP Sbjct: 67 TYQASVDGLVKHLNLTVEESYELIKSAVEFARTARDLYLQECQESNLSGRKPLIAGSVGP 126 Query: 125 YGAYLADGSEYRGDYH--CSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 YGAYL D SEY G+Y + E + +HR R++AL++AG D+LA ET+P E EAL E+ Sbjct: 127 YGAYLHDTSEYTGNYADNTTKETIKNWHRTRIQALVEAGVDILAFETIPCQKEAEALVEI 186 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALL--AGYPQVVALGINCIALENTTAALQ 240 L YP +AW SF+ ++ L+ G ++V + Q++A+G+N + + T + Sbjct: 187 LKEYPNMKAWLSFSCKNETSLAHGENFQNVAKKCWKSNPDQLIAIGVNGCSPKIVTELFK 246 Query: 241 HLH--GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRT 298 ++ T + + YPNSGE YD K + C L + + +W G R IGGCCRT Sbjct: 247 DINNDQETSIQYITYPNSGETYD--HKLGWTESDKCESLHNLVAEWLDLGVRYIGGCCRT 304 Query: 299 TPADIAALKARS 310 DI+ ++ + Sbjct: 305 NDVDISRIRIET 316 >UniRef50_Q01YW7 Methionine synthase (B12-dependent) n=5 Tax=Bacteria RepID=Q01YW7_SOLUE Length = 1185 Score = 277 bits (708), Expect = 4e-73, Method: Composition-based stats. Identities = 74/317 (23%), Positives = 133/317 (41%), Gaps = 29/317 (9%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSL-----WSAKVLVENPELIREVHLD 57 + L L+ Q +L+LDGAM T + ++ + V P++I+++H Sbjct: 7 RQKALNDSLE-QRVLVLDGAMGTMIHQAPLSIETDYLGRENCPEILNVTRPDVIQDIHRQ 65 Query: 58 YYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLL 117 Y AGA T ++ T A L E ++ L + +LAR+ + + + A Sbjct: 66 YLEAGADIIETNTFGGTRIALADNKL-EERAYELNFAAAKLAREVADQF---STAAKPRF 121 Query: 118 VAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE 177 VAGS+GP L + +A + + + L++ GAD L ET + ++ Sbjct: 122 VAGSIGPTNKDLNITGS------TTFPEIKAAYYEQAKGLVEGGADYLLIETCFDTGSLK 175 Query: 178 ALAELLTAYPR-----ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IA 231 A + R S T+ + + G + + A + + +++ +G+NC Sbjct: 176 AGLVAVEQLGRELAIQIPVVASVTIERTGTMLGGQQIDALYASIGNH-ELLGVGMNCATG 234 Query: 232 LENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG-AR 290 + T ++ L+ ++ + YPN+G GE LA L ++ G Sbjct: 235 PDLMTDHIRTLNEMSAHRISCYPNAGLP-----NAEGKFGETPDSLAAQLEKFANQGWLN 289 Query: 291 LIGGCCRTTPADIAALK 307 +GGCC TTPA I A+ Sbjct: 290 FVGGCCGTTPAHIQAIA 306 >UniRef50_B8FX16 Homocysteine S-methyltransferase n=2 Tax=Desulfitobacterium hafniense RepID=B8FX16_DESHD Length = 285 Score = 277 bits (708), Expect = 4e-73, Method: Composition-based stats. Identities = 74/301 (24%), Positives = 116/301 (38%), Gaps = 26/301 (8%) Query: 10 LLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITA 69 +LDK ++ DGAM T L+ + + PE+I EVH Y +AG+ T Sbjct: 2 ILDKDSYVIFDGAMGTMLQKYDLAPGQP--PEVLNITRPEVIEEVHRKYIKAGSNIITTN 59 Query: 70 SYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYL 129 ++ A G + A AG LVA VGP G + Sbjct: 60 TFGAIETKLNGTGYSVEEVVQ-------------SAIAIARRAAGKNLVALDVGPTGELI 106 Query: 130 ADGSEYRGDYHCSVEAFQAFHRPRVEALLDAG-ADLLACETLPNFSEIEALAELLTAYPR 188 + S E + +++A G DL+ ET + +E A + Sbjct: 107 EPLGD------LSFEEVYDLYACQIKAAALTGNVDLVLIETFFDLTEAHAAIRAAKDHSS 160 Query: 189 ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTV 247 +FT + G ++ VV L Y V A+G+NC + ++ + T Sbjct: 161 LPVICTFTFQQKGRTLMGKDIKTVVTSLEEY-GVDAVGVNCSLGPGEMLSIVETMVSSTQ 219 Query: 248 LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 LP++V PN+G +T + + A Y+ G + GGCC TTP I+A+K Sbjct: 220 LPILVQPNAGLPKLIGDRTV--YDVEPEEFARYIQVMANLGVKWFGGCCGTTPEFISAIK 277 Query: 308 A 308 Sbjct: 278 E 278 >UniRef50_B6GAW1 Putative uncharacterized protein n=1 Tax=Collinsella stercoris DSM 13279 RepID=B6GAW1_9ACTN Length = 848 Score = 276 bits (707), Expect = 5e-73, Method: Composition-based stats. Identities = 75/307 (24%), Positives = 112/307 (36%), Gaps = 27/307 (8%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 + L+ L LL DG M T L+ARG + + + +PE I +H Y +AG Sbjct: 1 MDTTLQRALAGTGHLLFDGGMGTMLQARGLAAGE--LPELLCLTHPEQITAIHQAYVQAG 58 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 + T ++ A A AQ + + +V AR+ +G LVA + Sbjct: 59 SDVITTNTFGANRLKLA----GRAQVRDVFRAAVACARQ-----------SGARLVAADI 103 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP GA L S + + A DAGADL ET+ + EI+A Sbjct: 104 GPIGALLRPLGT------LSFDEAYDLFAEQAHAAQDAGADLFIIETMTDLLEIKAAVLA 157 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQH 241 + + T GTP L V ALGINC + Sbjct: 158 CREQTDLPIFATMTFEADGRTFLGTPPEVAAVTLDAL-GVDALGINCSQGPAELRPLARR 216 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 + +T P++V N+G + T A + G ++GGCC T P Sbjct: 217 MLAVTEKPVIVQANAGLPHVEDGCTV--FDIEPEAYAQAVAGMVEDGVGILGGCCGTDPR 274 Query: 302 DIAALKA 308 + + Sbjct: 275 HVERMAE 281 >UniRef50_A6G853 Homocysteine methyltransferase n=3 Tax=Bacteria RepID=A6G853_9DELT Length = 325 Score = 276 bits (707), Expect = 6e-73, Method: Composition-based stats. Identities = 147/319 (46%), Positives = 186/319 (58%), Gaps = 21/319 (6%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 + L LL ++ +LDG +AT LEA GC+L D LWSA++L+++PE +R VH + AGA Sbjct: 9 DALDRLLAREPFAVLDGGLATSLEACGCDLDDPLWSARLLLDDPEALRTVHRRWRDAGAD 68 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP 124 TASYQA+ G A+GL EA++KAL+ +SV L R A + A P L+A SVG Sbjct: 69 ILATASYQASLPGLRAKGLSEARAKALLRESVTLTRAAADEANAPRP-----LIAASVGS 123 Query: 125 YGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 YGAYLADGSEYRG Y SVEA FHRPR+ L AG DL+A ET P+ E+ ALAELLT Sbjct: 124 YGAYLADGSEYRGGYGLSVEALADFHRPRLLELAAAGPDLIAFETFPDAVELAALAELLT 183 Query: 185 AYPRA------RAWFSFTLRDSE-----HLSDGTPLRDVVALLAGYPQVVALGINCIALE 233 RAW S +L L+DGTPL +A L +P+V ALG+NC+ Sbjct: 184 ELLTELGDTLPRAWISASLSPPGPDRSVRLADGTPLTKALAPLTDHPKVAALGVNCVGPR 243 Query: 234 NTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIG 293 AL+ L T PLV YPNSGE + + + W + A +W GARLIG Sbjct: 244 EVAPALEVLAACTDRPLVAYPNSGERW--IDRGWSGAALEPNKFAALAERWFELGARLIG 301 Query: 294 GCCRTTPADIAA---LKAR 309 GCCRT A I A L+ R Sbjct: 302 GCCRTNYAHIQALVKLRER 320 >UniRef50_Q5SKM5 5-methyltetrahydrofolate homocysteine S-methyltransferase n=5 Tax=Bacteria RepID=Q5SKM5_THET8 Length = 1185 Score = 276 bits (705), Expect = 1e-72, Method: Composition-based stats. Identities = 73/315 (23%), Positives = 125/315 (39%), Gaps = 34/315 (10%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREVHLDYYR 60 L+ALL + L+ DGAM TEL+ R D + PE++RE+HL Y Sbjct: 42 LKALL--ERPLVFDGAMGTELQKRDLTPEDYGGEAYFGCPEVLNRTRPEVVREIHLAYLE 99 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGA+ T ++ A A GL E ++ L +AR+A + + A VAG Sbjct: 100 AGAEVIETNTFGALRHVLAEYGL-EEAAEELAFLGARIAREAADPHGA--------FVAG 150 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 ++GP ++ G S +A ++ LL G DL+ ET + ++ Sbjct: 151 ALGPGTKLVSLGQ-------ISWDALYRAYKEAARGLLKGGVDLILLETAQDILQVRCAV 203 Query: 181 ELLTAY-----PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALEN 234 + T + + GT + +A L P V +G+NC + Sbjct: 204 LAVREAMAEVGREVPLQVQVTFEATGTMLVGTDEQAALAALESLP-VDVVGMNCATGPDL 262 Query: 235 TTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ-AAGARLIG 293 + +++ + + PN+G + + + +LA + ++ G +G Sbjct: 263 MDSKVRYFAEHSTRFVSCLPNAGLPRNEGGRVV--YDLTPEELAKWHLKFVAEYGVNAVG 320 Query: 294 GCCRTTPADIAALKA 308 GCC T P I + Sbjct: 321 GCCGTGPEHIRKVAE 335 >UniRef50_C7NB07 Methionine synthase n=6 Tax=Leptotrichia RepID=C7NB07_LEPBD Length = 1169 Score = 275 bits (704), Expect = 1e-72, Method: Composition-based stats. Identities = 76/311 (24%), Positives = 127/311 (40%), Gaps = 26/311 (8%) Query: 13 KQDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREVHLDYYRAGAQCA 66 K ILLLDGAM T ++ D + ++++ P++I+ +H Y AG+ Sbjct: 18 KNKILLLDGAMGTMIQQENLTADDFGGEKYEGCNDYLVLQRPDVIKNIHKKYLEAGSDII 77 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQ-AGTLLVAGSVGPY 125 T S+ A L E + K+ EL +A Y +E+P+ L VAG++GP Sbjct: 78 ETNSFGALDIVLKDYDL-EDTVFEMNKKAAELVNEAIAEYRSEHPEVTRNLYVAGALGPS 136 Query: 126 GAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEAL----AE 181 ++ + E + V L+ G DL+ ET+ + ++A + Sbjct: 137 NKSISVTG------GVTFEELIHTYYTAVSGLMAGGVDLILFETIQDTRNLKAAYLGLKK 190 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQ 240 + SFT+ + G D + ++G+NC E T L+ Sbjct: 191 AMEENYTVPLMLSFTIESTGTTLAGQT-ADAFYYAVNHMNPFSVGLNCATGPEFMTQFLK 249 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQL-ADYLPQWQAAGARLIGGCCRTT 299 L+ ++ + VYPN+G + E L A P +Q ++GGCC TT Sbjct: 250 TLNNISNTYISVYPNAGLP-----NEDGEYEETPDTLSAKIEPFFQNNYLNIVGGCCGTT 304 Query: 300 PADIAALKARS 310 P I +K +S Sbjct: 305 PEHIQKIKEKS 315 >UniRef50_C6D4G9 Methylenetetrahydrofolate reductase n=12 Tax=cellular organisms RepID=C6D4G9_PAESJ Length = 632 Score = 275 bits (704), Expect = 1e-72, Method: Composition-based stats. Identities = 85/307 (27%), Positives = 121/307 (39%), Gaps = 25/307 (8%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 LR L KQ IL DGAM T L G + S ++ + P++I VH YY AG Sbjct: 1 MKPDLRTKL-KQRILTGDGAMGTYLYQMGFPVGVSY--EELNMTRPDVIEGVHRRYYEAG 57 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 A+ T ++ A + GL E +A+ V +A+ A V G+V Sbjct: 58 ARVIETNTFSANLVKLSKYGL-EPDMEAINRAGVRIAKAAA---------GEDAYVVGAV 107 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 G A +++ALL G D + ET +F E+ L Sbjct: 108 GSIRAG--------KLKDVRTSEVSHAFERQLDALLVEGVDGILFETFYDFDEMRLALGL 159 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 + F +D DGT L D LL +G NC A++ Sbjct: 160 ARKLTQLPVICQFAAQDVGRTQDGTGLLDAFTLLKD-EGADVVGFNCRSGPNGIMRAVES 218 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 + G LPL ++PN+G K + + A+ Q+ GAR+IGGCC TTP Sbjct: 219 IGGPVELPLSIFPNAGIPDYVDGK--YKYSAGPDYFAETALQFADRGARIIGGCCGTTPE 276 Query: 302 DIAALKA 308 IAA+ Sbjct: 277 HIAAMAK 283 >UniRef50_UPI000050FD2A homocysteine methyltransferase n=1 Tax=Brevibacterium linens BL2 RepID=UPI000050FD2A Length = 308 Score = 273 bits (699), Expect = 4e-72, Method: Composition-based stats. Identities = 151/319 (47%), Positives = 188/319 (58%), Gaps = 27/319 (8%) Query: 1 MSQN--NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDY 58 MSQ + L+A + D L++DG + T LE+RG +L+ LWSA +L ++P+ + EVH D+ Sbjct: 1 MSQTFIHLLQAAVRSGDPLVIDGGLGTALESRGIDLSHELWSAALLRDSPDTLAEVHADF 60 Query: 59 YRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLV 118 RAGAQ TASYQATP GF + + LI +SVE+A AG LV Sbjct: 61 IRAGAQIVTTASYQATPLGFERASIPAEEGLRLIARSVEIA-----------AGAGDALV 109 Query: 119 AGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 AGSVGPYGA L +G+EY GDYH S E F AFHRPR+EAL++AGADLLA ET P+ SEI Sbjct: 110 AGSVGPYGAALGNGAEYTGDYHLSDEEFAAFHRPRIEALVNAGADLLAIETQPSLSEITV 169 Query: 179 LAELLTAYPRARAWFSFTLRDSEHLSDG------TPLRDVVALLAGYPQVVALGINCIAL 232 LA L Y AW S TL D L+DG TPL D+ +A + A+G+NC+ Sbjct: 170 LAGLADEY-GIPAWLSVTLADQGDLADGSHMADRTPLSDLAEAVADSRMIRAVGVNCVRP 228 Query: 233 ENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHH---GEHCAQLADYLPQWQAAGA 289 AL L T LPL+ YPNSGE YDA + W + LA W +AG Sbjct: 229 SLVAPALAALASATDLPLIAYPNSGETYDAATMEWREDSAFDTSPSTLAP----WVSAGV 284 Query: 290 RLIGGCCRTTPADIAALKA 308 R+IGGCCRTTPADIA L Sbjct: 285 RIIGGCCRTTPADIAGLAD 303 >UniRef50_C4R8J7 S-adenosylmethionine-homocysteine methyltransferase n=1 Tax=Pichia pastoris GS115 RepID=C4R8J7_PICPG Length = 321 Score = 273 bits (699), Expect = 5e-72, Method: Composition-based stats. Identities = 109/320 (34%), Positives = 166/320 (51%), Gaps = 20/320 (6%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M+ + + L ++ +LDGA+ TELE G ++ LWS K L +PE I ++H Y + Sbjct: 1 MTPITKMDSWLKQKRCRVLDGALGTELEKLGIDIKSRLWSGKALFYSPETITQIHSSYIQ 60 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGA+ +T +YQ + G G+D+ ++V+LA+ A + EN + G Sbjct: 61 AGAELILTCTYQLSDQGLKDLGIDDPDVYD---RAVKLAKDAVDQNEGEN----KAKIVG 113 Query: 121 SVGPYGAYLADGSEYRGDYH-CSVEAFQAFHRPRVEALL-DAGADLLACETLPNFSEIEA 178 S+G YGAYL+ G EY G+Y S + FHR R+++LL + DL+ ET+PN E E Sbjct: 114 SIGSYGAYLSGGEEYTGEYGAISKSELEEFHRVRLQSLLTNPDVDLIGFETIPNILEAET 173 Query: 179 LAELLTAYP-----RARAWFSFTLRDSEH---LSDGTPLRDVVALLAGY--PQVVALGIN 228 L L A + SF R+ + ++DGT + +V L+ ++ A+G N Sbjct: 174 LVVLFNALATSLNVDKGYYMSFNCREESNQSVIADGTSIPEVSDRLSKLDVSRMYAIGTN 233 Query: 229 CIALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG 288 C ++ A++ T LPL+VYPNSGE YD K W GE ++ D + W Sbjct: 234 CCSISTANGAVELFSKHTNLPLIVYPNSGERYDKTEKKWLP-GECDQKITDIVVNWLQLN 292 Query: 289 ARLIGGCCRTTPADIAALKA 308 ++IGGCCRT P I L+ Sbjct: 293 VKIIGGCCRTNPHFIRQLRD 312 >UniRef50_B9XKW8 Methylenetetrahydrofolate reductase n=1 Tax=bacterium Ellin514 RepID=B9XKW8_9BACT Length = 624 Score = 273 bits (699), Expect = 5e-72, Method: Composition-based stats. Identities = 84/307 (27%), Positives = 129/307 (42%), Gaps = 26/307 (8%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 +N L L Q +LL DGA+ T L RG L S + +++PE++ ++H DY AG Sbjct: 1 MSNFLNRL--NQGVLLGDGAIGTLLYQRGQPLNASY--DALNLQHPEIVSQLHRDYLDAG 56 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 A T ++ A GL + + +LA + VAGSV Sbjct: 57 AHLIETNTFGANRIKLEKFGLAQKTV-DINKHGAQLALEVA--------CGRGAFVAGSV 107 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP A + S D + +R ++EAL+ G D L ET E+ + + Sbjct: 108 GPLSADPSSLSTQTKD---------SAYREQLEALVSEGVDALFLETFNRLDELAFVLRI 158 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 + S + D H +DG + + + L +G+NC L+ Sbjct: 159 ARSLGNTPIIASLSFGDDGHTADGLRINEAFSRLKE-AGADVVGLNCHFGPTIAEKLLEE 217 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 L + +YPN+G Y + + + + AD+ P+ A GARLIGGCC TTP Sbjct: 218 LIVRPGDLISIYPNAGRPYFYEGR--YIYHSTPSYFADFAPKLIAQGARLIGGCCGTTPE 275 Query: 302 DIAALKA 308 IAA+ Sbjct: 276 TIAAMAR 282 >UniRef50_A9A1I5 Homocysteine S-methyltransferase n=2 Tax=Thaumarchaeota RepID=A9A1I5_NITMS Length = 320 Score = 273 bits (698), Expect = 6e-72, Method: Composition-based stats. Identities = 70/321 (21%), Positives = 124/321 (38%), Gaps = 25/321 (7%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLAD-----SLWSAKVLVENPELIREVH 55 M++ P L + +LL DGAM TE++ D ++ ++V P+ I+++H Sbjct: 1 MTEKEPFLDAL-QNRVLLFDGAMGTEIQKFNPKPEDFPNNQDGFNDGLVVTRPDWIKQIH 59 Query: 56 LDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGT 115 Y AGA C T S+ + G + Q+ K +LA + + Y Sbjct: 60 RHYLDAGADCIETNSFGSNKIKLDEYGFGD-QTIEFNKKIAQLASEVCQEY-----SDRP 113 Query: 116 LLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE 175 V GS+GP G + G + + + E L+ G D L ET + E Sbjct: 114 RYVIGSMGPSGFLPSSNDPDLGQKPL--DEIKEAFELQAEGLILGGVDALLIETSQDILE 171 Query: 176 IEALAELL-----TAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC- 229 ++ + E + + TL + GT ++ ++ + G+NC Sbjct: 172 VKLVIEACHQAMEKTGKKIPIIANTTLDQYGKMLLGTNIQAAYTTVSDM-GIDVFGMNCS 230 Query: 230 IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAA-- 287 T +++ L ++V PN+G + + + ++ D L + Sbjct: 231 TGPIEMTPSVRWLDEQNEHNILVVPNAGMPENEGGQAV--YKMTPEKMGDALGDFLNQYK 288 Query: 288 GARLIGGCCRTTPADIAALKA 308 R+IGGCC T P I L+ Sbjct: 289 KVRIIGGCCGTNPEHIKVLRK 309 >UniRef50_UPI0001BC43AA B12-dependent methionine synthase n=1 Tax=Fusobacterium ulcerans ATCC 49185 RepID=UPI0001BC43AA Length = 1113 Score = 273 bits (698), Expect = 7e-72, Method: Composition-based stats. Identities = 62/307 (20%), Positives = 120/307 (39%), Gaps = 19/307 (6%) Query: 13 KQDILLLDGAMATELEARGCNLADS----LWSAKVLVENPELIREVHLDYYRAGAQCAIT 68 K+ +L+LDGA T ++ D + + + P++I+E+H Y AGA T Sbjct: 6 KKRVLVLDGATGTAIQKYNLTDEDFQGKKGCNEILNITRPDVIKEIHTKYIEAGADIIET 65 Query: 69 ASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 S+ + E S L K ELAR+ + + + VAGS+GP Sbjct: 66 NSFNCNRISLKDYEI-EDMSYTLSKKGAELARETADNFYK--TSGKKIYVAGSIGPTSKS 122 Query: 129 LA-DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYP 187 L+ + + + + + + ++E ++D G D L ET+ + +A Sbjct: 123 LSLPMGDVPYEREINFDQMKKIYSEQIEGVIDGGVDCLLIETIFDGLSAKAALVAAEELF 182 Query: 188 RA-----RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQH 241 S T+ + G + ++ L P +++ G+NC + ++ Sbjct: 183 EKKNIQLPIMISATVNRQGKIFSGQSIESLITAL-DRPSIISFGLNCSFGARDLIPMIKR 241 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 + T + +YPN+G + + L + + + ++GGCC T + Sbjct: 242 IASFTDKYISLYPNAGLP-NEEGEYEETPEITAGYLKELVDE---KKVNILGGCCGTHFS 297 Query: 302 DIAALKA 308 I A+ Sbjct: 298 HIKAIAD 304 >UniRef50_Q146H9 Methionine synthase (B12-dependent) n=21 Tax=cellular organisms RepID=Q146H9_BURXL Length = 359 Score = 273 bits (698), Expect = 7e-72, Method: Composition-based stats. Identities = 83/329 (25%), Positives = 132/329 (40%), Gaps = 32/329 (9%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEARGCNLAD-------------SLWSAKVLVENP 48 ++ L ALL K IL+LDGAM T ++ + A + + + P Sbjct: 18 TRGAALPALL-KSRILILDGAMGTMIQRYKLDEARYRGERFKDYGRDIKGNNELLSITQP 76 Query: 49 ELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLA 108 ++I E+H Y AGA T ++ AT A G+ EA + + +S +LAR A + Y Sbjct: 77 QIISEIHEQYLAAGADIVETNTFGATTVAQADYGM-EALAVEMNLESAKLARAACDKYST 135 Query: 109 ENPQAGTLLVAGSVGPYGAY--LADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLA 166 VAG++GP ++ G + + + +A + + ALLD G DL Sbjct: 136 P---DKPRFVAGAIGPTPKTASISPDVNDPGARNVTFDELRAAYYEQARALLDGGVDLFL 192 Query: 167 CETLPNFSEIEALAELLTAY-----PRARAWFSFTLRD-SEHLSDGTPLRDVVALLAGYP 220 ET+ + +A L R S T+ D S + G + + + Sbjct: 193 VETIFDTLNAKAALFALDELFEDTGERLPIMISGTVTDASGRILSGQTV-EAFWNSLRHA 251 Query: 221 QVVALGINCI-ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLAD 279 + + G+NC + L L + YPN+G E A + Sbjct: 252 KPLTFGLNCALGAALMRPYIAELAKLCDTYVSCYPNAGLPNPMSD---TGFDELPADTSG 308 Query: 280 YLPQWQAAG-ARLIGGCCRTTPADIAALK 307 L ++ AG + GGCC TTP IAA+ Sbjct: 309 LLKEFAQAGLVNIAGGCCGTTPEHIAAIA 337 >UniRef50_D0MU48 Methionine synthase n=1 Tax=Phytophthora infestans T30-4 RepID=D0MU48_PHYIN Length = 1203 Score = 272 bits (696), Expect = 1e-71, Method: Composition-based stats. Identities = 77/324 (23%), Positives = 132/324 (40%), Gaps = 32/324 (9%) Query: 11 LDKQDILLLDGAMATELE--------ARGCNLADSLW-----SAKVLVENPELIREVHLD 57 L KQ L+ DG M T ++ R DS + + + P +I+E+H Sbjct: 31 LMKQRTLIFDGGMGTMIQVHKFTEEDFRSERFKDSPCLVKGNNDLLSITQPHIIKEIHKQ 90 Query: 58 YYRAG-AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTL 116 Y + G AQ T ++ T A + E L +S +LAR+A + +P Sbjct: 91 YMQIGRAQLIGTNTFSGTTIAQADYQM-EHLVYELNYESAKLAREAADEVTQLDPLL-PR 148 Query: 117 LVAGSVGPYGAYLA--DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFS 174 VAGS+GP L+ E G + + + + +VE L+D G+D+L ET+ + Sbjct: 149 FVAGSIGPTNRTLSISPNVEDPGFRNVTFDELVDAYYTQVEGLVDGGSDVLLVETIFDTL 208 Query: 175 EIEALAELLTAY-----PRARAWFSFTLRD-SEHLSDGTPLRDVVALLAGYPQVVALGIN 228 +A + Y + + S T+ D S G + + + + +G+N Sbjct: 209 NAKAAVFAINKYQEATGRKLPLFISGTIVDMSGRTLSGQT-TEAFYVSLRHSKPFCIGLN 267 Query: 229 CI-ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW-QA 286 C LQ L + + VY N+G + + A +A+Y ++ + Sbjct: 268 CALGANQMKPFLQRLANVAECFVSVYANAGLPNAMGG-----YDDTPAMMAEYCEEFSKD 322 Query: 287 AGARLIGGCCRTTPADIAALKARS 310 ++GGCC TTP I A+ + Sbjct: 323 RLVNMMGGCCGTTPQHIQAIAKMT 346 >UniRef50_C4LIL8 5-methyltetrahydrofolate--homocysteinemethyltransferase n=7 Tax=Actinomycetales RepID=C4LIL8_CORK4 Length = 1240 Score = 272 bits (695), Expect = 1e-71, Method: Composition-based stats. Identities = 64/319 (20%), Positives = 128/319 (40%), Gaps = 26/319 (8%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEARGCNLAD-----SLWSAKVLVENPELIREVHL 56 ++ L+AL D +L+ DGAM T+L+A +L + + + P+++ ++H Sbjct: 24 KKSEFLQALHD--RVLIGDGAMGTQLQAIDLDLDADFHGLEGCNEILNITRPDILADIHR 81 Query: 57 DYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTL 116 Y+ AGA T ++ FA G+ E + + + ++AR + + + Sbjct: 82 RYFEAGADAVETNTFGCNLPNFADYGI-EDRIEEIAYAGTQIARSVADD-MGPGREGMKR 139 Query: 117 LVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEI 176 V GS+GP G++ + + + L+ GAD + ET + ++ Sbjct: 140 FVLGSLGP-------GTKLPTLGNAPFSDLRDAYTEAAHGLVRGGADAILIETAQDLLQV 192 Query: 177 EALAELLTAYPR-----ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-I 230 +A + T+ + + G+ + + L + +G+NC Sbjct: 193 KAAVHGVQQAFDDYGTTLPIMCHVTVETTGTMLLGSEIGAALTALERL-GIDVIGMNCAT 251 Query: 231 ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ-AAGA 289 + L++L +P+ V PN+G + + +LA + G Sbjct: 252 GPDEMNEHLRYLSAHAPMPVSVMPNAGLPELGANGAV--YPLTPDELAAASVHFVRDYGL 309 Query: 290 RLIGGCCRTTPADIAALKA 308 ++GGCC TTP I A++ Sbjct: 310 SMVGGCCGTTPEHITAVRD 328 >UniRef50_A6LKZ2 Homocysteine S-methyltransferase n=6 Tax=Bacteria RepID=A6LKZ2_THEM4 Length = 781 Score = 271 bits (694), Expect = 2e-71, Method: Composition-based stats. Identities = 64/308 (20%), Positives = 119/308 (38%), Gaps = 24/308 (7%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 + LL+ + I LDGA TE G + V N E++ + Y AG Sbjct: 10 ERKEFLELLN-ERIYFLDGAYGTEFFKLGFKEVI----ETLNVTNSEMVYALQKAYVDAG 64 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 +T ++ A ++ + + K + +V++A+KAR+ + + G + Sbjct: 65 VDFLLTNTFSANRLKLSSLKV-KYNLKDINYNAVKIAKKARK--------DKKVYILGDI 115 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 G ++ E + + + + E LL++G D ET+ + E++A Sbjct: 116 SSTGYLISPLGE------LTFDEAYEVFKEQGEILLNSGIDGFILETMSDLKELKAAILA 169 Query: 183 LTAYP-RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQ 240 L T + GT + ++ + L V +GINC E + Sbjct: 170 LRDLSKDVPIIVQMTFDEDGVAVTGTSV-EIFSTLMNDLDVDVVGINCTLEPEKLLPVFK 228 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 L + P+ V PN+G+ + + + A Y+ + GA ++GGCC T+P Sbjct: 229 QLSNYSRKPISVEPNAGKPKLLRDGSI-VYNTSPEKFALYMEDFVEFGANIVGGCCGTSP 287 Query: 301 ADIAALKA 308 I + Sbjct: 288 EHIRLMVE 295 >UniRef50_A8SP62 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=A8SP62_9FIRM Length = 808 Score = 271 bits (692), Expect = 3e-71, Method: Composition-based stats. Identities = 71/309 (22%), Positives = 125/309 (40%), Gaps = 21/309 (6%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 R L D + IL+LDGA T L G L + + ++E+ +++ ++ Y AG Sbjct: 2 NKTEFRKLFDDK-ILILDGATGTNLMDAGMPLG--VCPEQWILEHKQIMIDLQTAYLNAG 58 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 ++ GL + ++ + V+L++KA E AG LVAG + Sbjct: 59 TDILYAPTFTCNRIKLNEYGLADNLV-SMNSELVKLSQKAVE-------NAGHGLVAGDI 110 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 G L + + E ++ +++ L ++G DLL ET+ + +E A Sbjct: 111 TMTGEMLYPMGKLQ------FEELVDVYKEQIKVLDESGCDLLVVETMMSLAETRAAVIA 164 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 + S T + GT V +L V A+G+NC + ++ Sbjct: 165 ANEVSKLPIIASLTFNEDGRTLYGTDPVTAVNVLQNL-GVAAIGVNCSTGPDKMVELVKQ 223 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 + + +P+ PN+G K+ + + A + AGA ++GGCC T P Sbjct: 224 MKSIAFIPVFAKPNAGMPELVDDKSV--YKMTPEEFAADMKLIIEAGAGMVGGCCGTRPD 281 Query: 302 DIAALKARS 310 I AL + Sbjct: 282 HIKALSDMA 290 >UniRef50_O06745 5,10-methylenetetrahydrofolate reductase n=78 Tax=Bacillus RepID=YITJ_BACSU Length = 612 Score = 270 bits (691), Expect = 4e-71, Method: Composition-based stats. Identities = 75/297 (25%), Positives = 126/297 (42%), Gaps = 27/297 (9%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 ++ +L+ DGAM T L + G + ++ + PE I+ +H Y AGA T +Y Sbjct: 8 QRQVLIGDGAMGTLLYSYGID----RCFEELNISKPEEIQRIHKAYVEAGANIIQTNTYG 63 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A + GL E K + ++V++AR AG V G++G G + Sbjct: 64 ANYIKLSRHGL-EDDIKKMNQEAVKIAR----------ASAGDAYVLGTMG--GIRTFNK 110 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 + Y S++ + R ++ LL D L ET + E + ++ Sbjct: 111 NAY------SLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETDLPIM 164 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLV 251 + ++ + L DGTPL D + +A +GINC + + AL + + L Sbjct: 165 LNVSMHEQGVLQDGTPLSDALRSIADL-GADIVGINCRLGPYHMIEALSEVPIFDDVFLS 223 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 VYPNS + + + + +++ GAR+IGGCC TTP I A+ Sbjct: 224 VYPNSSLPSLEEGRLVYETDDT--YFQNSASEFRKQGARIIGGCCGTTPNHIRAMAE 278 >UniRef50_B8DYM9 Homocysteine S-methyltransferase n=1 Tax=Dictyoglomus turgidum DSM 6724 RepID=B8DYM9_DICTD Length = 290 Score = 270 bits (691), Expect = 4e-71, Method: Composition-based stats. Identities = 78/312 (25%), Positives = 124/312 (39%), Gaps = 31/312 (9%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 MS + + L DGAM TEL+ RG + +ENP L+ EVH DY + Sbjct: 1 MSNKK-----IKLPEFLFFDGAMGTELQRRGLPPGTP--PEILNLENPSLVEEVHKDYIK 53 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AG+ T ++ GL E + K + K VE+A+KA G +L+AG Sbjct: 54 AGSMVIETNTFGGNRVRLQRAGL-EEKIKEINEKGVEIAQKA---------SEGKVLIAG 103 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 SVGP G + + S E + F ++E L+++G DL+ ET+ + +E Sbjct: 104 SVGPLGELIEPYGD------ISEEEAEEFFTEQIEILVNSGVDLILIETMISLNEALIAL 157 Query: 181 ELLTAYPRARAWFSFTL---RDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTT 236 + + + + G + + L +G NC E+ Sbjct: 158 KSAKKF-DIPVGVTMSFEWTEKGGRTPFGDEVEYSIKKLEE-NGADFVGSNCGKGFEDML 215 Query: 237 AALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCC 296 + T LP+++ PN+G K + E + ++ + IGGCC Sbjct: 216 KIAPIIRRSTRLPVLIQPNAGIPRWENGKL--LYPESPEKFKTFVDEMIKLKINFIGGCC 273 Query: 297 RTTPADIAALKA 308 TTP I K Sbjct: 274 GTTPKHIEVFKE 285 >UniRef50_C1SMZ8 5-methyltetrahydrofolate--homocysteine methyltransferase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SMZ8_9BACT Length = 1116 Score = 269 bits (688), Expect = 9e-71, Method: Composition-based stats. Identities = 75/310 (24%), Positives = 126/310 (40%), Gaps = 34/310 (10%) Query: 11 LDKQDILLLDGAMATELEARGCNLADSLW------SAKVLVENPELIREVHLDYYRAGAQ 64 K I+L DGAM T ++ + D +W S + V PE+I+++H Y+ AGA Sbjct: 5 FAKNRIILFDGAMGTSIQNY--EITDEIWQGYNGCSEWLNVAAPEIIQQIHEQYFEAGAD 62 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP 124 T ++ T + L + ++ L ++AR+A + Y AGS+GP Sbjct: 63 VVETNTFGGTELVMSEYDLQD-RTYELNLLGAQIARRAADKYGK--------YTAGSIGP 113 Query: 125 YGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL-- 182 G++ S + + + EALL+ G DL ET + +I++ Sbjct: 114 -------GTKLPSLGQISYDDLYTMYHSQAEALLEGGVDLFIIETCQDLLQIKSALNAVI 166 Query: 183 ---LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAA 238 A S T+ + + GT + V LL YP V +LG+NC + Sbjct: 167 DVKAEKNSDAPVMVSITVEQNGTMLMGTDISAAVTLLREYP-VFSLGLNCSTGPDLMHNP 225 Query: 239 LQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ-AAGARLIGGCCR 297 + L + PN+G + + + ++A + ++GGCC Sbjct: 226 INDLAQNFNGRISCIPNAGLPENRGGQMV--YDMTPDKMAKIVEGMVQEFPIGVLGGCCG 283 Query: 298 TTPADIAALK 307 TTP I AL+ Sbjct: 284 TTPEHIKALR 293 >UniRef50_UPI0001C311AB homocysteine S-methyltransferase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C311AB Length = 1189 Score = 269 bits (688), Expect = 9e-71, Method: Composition-based stats. Identities = 80/317 (25%), Positives = 126/317 (39%), Gaps = 29/317 (9%) Query: 7 LRALLD--KQDILLLDGAMATELEARGCNLAD-----SLWSAKVLVENPELIREVHLDYY 59 +R LD + +++ DG M LE D +++ P++I VH Sbjct: 1 MRDYLDAIRSRVVVFDGGMGATLEQFELTEKDYGGLQGKCHEALILHRPDVIEGVHTTML 60 Query: 60 RAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVA 119 AGA T ++QA+ GL E + + E+ARKA + VA Sbjct: 61 DAGADVVETDTFQASRLKLEEWGLGEHTL-EINRRGAEIARKAAGEH---------RYVA 110 Query: 120 GSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEAL 179 GS+GP G S+ + S A + + L++ GADLL ET + E++A Sbjct: 111 GSIGPTGFL--PASDDPTLGNISFRALVEVFAEQAQGLIEGGADLLMIETAQDILEVKAS 168 Query: 180 AELLTAY-----PRARAWFSFTL-RDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IAL 232 + S +L + + GT + V+ L V ALG+NC Sbjct: 169 VFGAREAFKTTGRKIPIQVSVSLLPNGGKMLLGTDISAVLTTLTAL-DVDALGLNCSTGP 227 Query: 233 ENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQA-AGARL 291 E+ A++ L + +P+ PN+G E LA L ++ G + Sbjct: 228 EDMRDAIRFLGEFSPVPVHCIPNAGLP-LQGPDGETIFPEKPEPLAASLTEFVERYGVSI 286 Query: 292 IGGCCRTTPADIAALKA 308 +GGCC TT A I A+ Sbjct: 287 VGGCCGTTAAHIRAIAD 303 >UniRef50_C8X6V8 Homocysteine S-methyltransferase n=14 Tax=Actinomycetales RepID=C8X6V8_NAKMY Length = 320 Score = 269 bits (688), Expect = 9e-71, Method: Composition-based stats. Identities = 133/296 (44%), Positives = 177/296 (59%), Gaps = 7/296 (2%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 L+LDG +AT LEA G +L +LWSA++LV+NP I H +Y+RAGAQ AITASYQA+ Sbjct: 14 RPLVLDGGLATLLEAHGHDLTSALWSAQLLVQNPGAITAAHREYFRAGAQVAITASYQAS 73 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAE--NPQAGTLLVAGSVGPYGAYLADG 132 G AA GL +++ + +SV+LAR A + E P +G VA SVGPYGA LADG Sbjct: 74 LPGLAAIGLGRVEAEQALRRSVDLARTAAADGVNEATAPGSGPRWVATSVGPYGAALADG 133 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 SEYRGDY +V + +HRPR+E L DAG D+LA ET+P +E+EAL + A A AW Sbjct: 134 SEYRGDYGLTVRQLRDWHRPRLEILADAGGDVLAIETIPCAAEVEALLTEIQAL-DAPAW 192 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVV 252 S T +D G + +V A+ AG QV+A+G+NC+ + + P VV Sbjct: 193 LSLTCQD-GRTRAGERVDEVFAMAAGVDQVIAVGVNCVESAEAADLVAAAAENSGKPAVV 251 Query: 253 YPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 YPNSGE +DA ++ W ++ W A+GARL+GGCCR P I L Sbjct: 252 YPNSGEDWDAQARAWAGRATFGP---EHAAVWVASGARLVGGCCRVGPQAIRRLAR 304 >UniRef50_UPI00016C59CA 5-methyltetrahydrofolate--homocysteine S-methyltransferase n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C59CA Length = 1198 Score = 269 bits (688), Expect = 1e-70, Method: Composition-based stats. Identities = 68/326 (20%), Positives = 127/326 (38%), Gaps = 28/326 (8%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWS----------AKVLVENPELI 51 S +P L ++ + +LDG M T L D +S ++ +P+ I Sbjct: 4 SFRHPFLD-LARERVAILDGGMGTSLHKYKPTEKDWGYSSAGKSLMNLSDALVYTHPDWI 62 Query: 52 REVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENP 111 RE+H ++ AG T ++ A G G+ + Q + ++ LA++ + Sbjct: 63 REIHRGFFAAGCDGVETNTFNANAIGLGEFGMAD-QLDEINRLNIRLAKEVAAEFA---T 118 Query: 112 QAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLP 171 V GSVGP + + ++ +R + +++ D + ET Sbjct: 119 ADRPRFVIGSVGPGTKMPSLTD---PAIYIDFDSLADAYRTQFRVMIEERVDAILIETCF 175 Query: 172 NFSEIEALAELL-----TAYPRARAWFSFT-LRDSEHLSDGTPLRDVVALLAGYPQVVAL 225 + E + A A R T + +++ + GT + + L ++ L Sbjct: 176 DILEAKCAAVAAIEEMKRAGVRLPLMVQLTIINENKKMLPGTDIATGLVTLDPIDEIDVL 235 Query: 226 GINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW 284 G+NC + + ++HL + L V PN+G +T+ A + ++ Sbjct: 236 GMNCGVGPDWMDEDVRHLSRHSRKLLSVLPNAGMPETRGDETY--FPLDPEGFAKWQERF 293 Query: 285 Q-AAGARLIGGCCRTTPADIAALKAR 309 GA +IGGCC TT A + A+ R Sbjct: 294 VTEHGANIIGGCCGTTHAHLKAVCDR 319 >UniRef50_C3XLV5 S-methyltransferase n=2 Tax=Helicobacter RepID=C3XLV5_9HELI Length = 1154 Score = 267 bits (683), Expect = 3e-70, Method: Composition-based stats. Identities = 73/309 (23%), Positives = 133/309 (43%), Gaps = 22/309 (7%) Query: 13 KQDILLLDGAMATELEARGCN--------LADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 K+ +L+LDGAM TE++ S + + ++I+ +H Y +AGA Sbjct: 8 KERVLILDGAMGTEIQKHNIQTWGVNAKGEKLDGCSEALNLYAKDIIKAIHTSYLQAGAN 67 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP 124 T ++ P A GL+E K + VELA++ + + Q L VA S+GP Sbjct: 68 ILKTNTFGVMPWVLAEYGLEEH-CKEIAKTGVELAKECIKKHSPLKNQNNALFVAASLGP 126 Query: 125 YGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 G++ H + ++ + + VE +A AD++ ET + +I+A + Sbjct: 127 -------GTKLPSLGHITYDSMEEGYALCVEGFKEADADVILLETAQDPLQIKAALNAIK 179 Query: 185 -AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHL 242 P S T+ + + GT + + +L Y +++LGINC + + L L Sbjct: 180 NTAPEIPIMVSVTIETTGTMLIGTDITTLFHILEPY-DLLSLGINCGLGPDLAHKHLVTL 238 Query: 243 HGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQA-AGARLIGGCCRTTPA 301 + P+ ++ N+G + T+ + + + + G +GGCC TTP Sbjct: 239 SEVCKFPISIHTNAGLPENRGGVTY--YPMDAEEFSTIEKSFLEIPGVAFLGGCCGTTPE 296 Query: 302 DIAALKARS 310 I L ++ Sbjct: 297 HIRQLVQKT 305 >UniRef50_A6QBA6 5-methyltetrahydrofolate--homocysteine methyltransferase n=6 Tax=Bacteria RepID=A6QBA6_SULNB Length = 1169 Score = 266 bits (679), Expect = 1e-69, Method: Composition-based stats. Identities = 72/324 (22%), Positives = 127/324 (39%), Gaps = 31/324 (9%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLA---------DSLWSAKVLVENPELI 51 MS +++LL+K IL++DGAM T+++ + + +LI Sbjct: 1 MSITETIKSLLEK-RILVIDGAMGTQIQDLDVPKEAWIDHSGKEQEGCNELLNDTAADLI 59 Query: 52 REVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENP 111 + +H Y AGA T ++ P + E ++ L K EL ++ Y + Sbjct: 60 KRIHKRYAMAGADLIKTNTFGTMPWVLDEYQMGE-RAYELSKKGAELVKEICAEYSTKIS 118 Query: 112 QAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLP 171 V GS+GP G++ H + ++ L+D G D+ ET Sbjct: 119 ---PKFVLGSIGP-------GTKLPSLGHIHYDEMYEGYKTVALGLIDGGCDVFLLETCQ 168 Query: 172 NFSEIEALAELLTAYP-----RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALG 226 + +I+A S T+ S + GT +V ++ + +++LG Sbjct: 169 DPLQIKAALHACQDANKERGVELPVMVSVTIELSGSMLIGTDATTIVTIMEPF-DILSLG 227 Query: 227 INC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ 285 NC + L+ L L +P+ V+ N+G + T+ + + ++ Sbjct: 228 FNCGTGPDQVKKHLKTLSELCSIPISVHANAGLPQNRGGYTY--YPMGPDEFTQKQLEFT 285 Query: 286 A-AGARLIGGCCRTTPADIAALKA 308 G +GGCC TTP I ALK Sbjct: 286 EFDGVSFLGGCCGTTPQHIQALKK 309 >UniRef50_Q6AL45 Related to 5-methyltetrahydrofolate--homocysteine methyltransferase n=1 Tax=Desulfotalea psychrophila RepID=Q6AL45_DESPS Length = 316 Score = 266 bits (679), Expect = 1e-69, Method: Composition-based stats. Identities = 69/308 (22%), Positives = 122/308 (39%), Gaps = 25/308 (8%) Query: 11 LDKQDILLLDGAMATELEARGCNLAD----SLWSAKVLVENPELIREVHLDYYRAGAQCA 66 + +L+ DGA T L++ + + + + + PE I E+H + AGA Sbjct: 3 FTDESLLIFDGACGTTLQSMNIAPSAWGDLAGCNEFLNISAPEYIIELHKKFLEAGAMVV 62 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 T ++ A+ GL E + + ++V+ A+KA + +AGS+GP Sbjct: 63 ETNTFGASSIVLTEYGL-ENKVDEINREAVKNAKKAI---SQLKDSSQPRYIAGSIGPTT 118 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 H + R +V +LL+AG D L ET + +++ Sbjct: 119 KL-------PSLGHIETKVLAQSIREQVISLLEAGVDALIVETCQDLLQLKTALISCFEI 171 Query: 187 -----PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQ 240 + S T + GT + V A LA +P + +LG+NC + + +Q Sbjct: 172 LDVAPKKLPVLASVTFEKQGTMLLGTDIAAVCATLAPFP-LFSLGLNCATGPTDMVSQIQ 230 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ-AAGARLIGGCCRTT 299 +L + PN G KT H+ + + ++ ++ G ++GGCC T Sbjct: 231 YLSQTWDKRISCIPNQGMPELKDGKT--HYPLSPEEYSQHMLKFVAEYGVSIVGGCCGTG 288 Query: 300 PADIAALK 307 P I L Sbjct: 289 PEHIRQLA 296 >UniRef50_C3RK90 Homocysteine S-methyltransferase n=3 Tax=Bacteria RepID=C3RK90_9MOLU Length = 793 Score = 266 bits (679), Expect = 1e-69, Method: Composition-based stats. Identities = 72/308 (23%), Positives = 126/308 (40%), Gaps = 21/308 (6%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRA 61 + L+ L K DIL+ DGAM T+L+ G D + + +P+LI+ +HL+Y A Sbjct: 6 KRTKMLQERL-KNDILVFDGAMGTQLQDAGLKAGD--IPECLNITDPKLIQTIHLNYLNA 62 Query: 62 GAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGS 121 GA T ++ A P A + +I +++ A AR+ +N + Sbjct: 63 GADFITTNTFGANPLKMAEAPYS---YEEIINAAIDNATIARKTADRQN----DSYIVLD 115 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 +GP G L + + + +V + D + ET+ + E++A Sbjct: 116 IGPIGQLLEPMGT------LTFDEAYEIIKKQV-IIAKDKVDAVLLETMTDIYEVKAGIL 168 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQ 240 + + + T ++ G +V +L G V LG+NC T + Sbjct: 169 AVKENSDLPVFVTMTYENNLRTLSGCDPLTMVNVLEGL-NVDVLGVNCSLGPIELTPIID 227 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 + +P+++ PN+G KT ++ + + G +IGGCC TTP Sbjct: 228 QILAAATIPVLLQPNAGLPCLVEGKTCYNMDK--ETFVQESLKHVKNGVAIIGGCCGTTP 285 Query: 301 ADIAALKA 308 IA+LK Sbjct: 286 DFIASLKN 293 >UniRef50_C7JFY7 Methionine synthase n=8 Tax=Acetobacter pasteurianus RepID=C7JFY7_ACEP3 Length = 1187 Score = 266 bits (679), Expect = 1e-69, Method: Composition-based stats. Identities = 73/318 (22%), Positives = 134/318 (42%), Gaps = 28/318 (8%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLW-----SAKVLVENPELIREVH 55 MS PL L Q +LL DG M + ++ ++ W + + + PELIRE+H Sbjct: 20 MSSRLPLLDALRDQ-VLLCDGGMGSRIQMLDLDVQRDYWGQENCTEILTLSRPELIREIH 78 Query: 56 LDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGT 115 Y+ AGA T ++ +P L + +++ + S LAR+A E++ + T Sbjct: 79 RGYFEAGADMVETNTFGGSPITLGEFSLTD-KAREINKNSAILAREAAESF----ADSRT 133 Query: 116 LLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE 175 V GS+GP G++ + ++ +A + L++ G D + ET + + Sbjct: 134 RYVLGSMGP-------GTKLPSLGNIDYDSLEAALAEQARGLIEGGVDAILIETCQDTLQ 186 Query: 176 IEALAELLTAYPR-----ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC- 229 I+A + + + T+ + L G + ++ V +G+NC Sbjct: 187 IKAAVNGVKIARKELGTTTPIFVQVTVETTGTLLVGPDIAAAATVIHSL-DVDLMGLNCA 245 Query: 230 IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ-AAG 288 + ++ L + V PN+G +T H+ A++A ++ ++ G Sbjct: 246 TGPQEMAEHVKWLSENWPRLISVQPNAGLPELVNGQT--HYPLTPAEMATWVERFITEDG 303 Query: 289 ARLIGGCCRTTPADIAAL 306 LIGGCC T+ AL Sbjct: 304 LNLIGGCCGTSTPHTEAL 321 >UniRef50_D2UDY2 Probable 5-methyltetrahydrofolate-homocysteine methyltransferase protein n=1 Tax=Xanthomonas albilineans RepID=D2UDY2_XANAL Length = 380 Score = 264 bits (676), Expect = 2e-69, Method: Composition-based stats. Identities = 79/341 (23%), Positives = 133/341 (39%), Gaps = 53/341 (15%) Query: 14 QDILLLDGAMATELEARGCNLAD--------------------SLW------------SA 41 + IL++DGAM T ++ G AD + Sbjct: 29 ERILIIDGAMGTMIQRHGLQEADYRGDRFAAGYDSAQPPHVHGPGCDHAMHGHDLKGNND 88 Query: 42 KVLVENPELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARK 101 +L+ PE+I E+H Y AGA T ++ AT A L E L +AR Sbjct: 89 LLLLTRPEVIAEIHSAYLEAGADLLETNTFNATAISQADYHL-EHLVYELNKAGARVARD 147 Query: 102 AREAYLAENPQAG----TLLVAGSVGPY--GAYLADGSEYRGDYHCSVEAFQAFHRPRVE 155 +A A+ +AG V G +GP A ++ G + S + +A +R ++ Sbjct: 148 CCDAVEAQQARAGGPDKPRFVIGVLGPTSRTASISPDVNDPGYRNTSFDELRATYREAID 207 Query: 156 ALLDAGADLLACETLPNFSEIEALAELLTAYPR-----ARAWFSFTLRD-SEHLSDGTPL 209 L+D GAD L ET+ + +A + S T+ D S G Sbjct: 208 GLIDGGADTLMVETIFDTLNAKAALYAIEEVFDARGGRLPVMISGTITDASGRTLSGQT- 266 Query: 210 RDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWH 268 + + + +++G+NC ++ ++ L + + +PN+G + Sbjct: 267 AEAFYASVAHGRPLSVGLNCALGAKDLRPHVETLARIADGYVSTHPNAGLP-----NAFG 321 Query: 269 HHGEHCAQLADYLPQWQAAG-ARLIGGCCRTTPADIAALKA 308 + E ++A L ++ AG L+GGCC TTPA I A+ Sbjct: 322 EYDETPEEMAATLKEFAEAGLLNLVGGCCGTTPAHIRAIAE 362 >UniRef50_C0QY88 5-methyltetrahydrofolate--homocysteine methyltransferase n=2 Tax=Brachyspira RepID=C0QY88_BRAHW Length = 873 Score = 264 bits (675), Expect = 3e-69, Method: Composition-based stats. Identities = 71/325 (21%), Positives = 134/325 (41%), Gaps = 31/325 (9%) Query: 4 NNPLRALLDKQDILLLDGAMATELEARGCNLAD--------SLWSAKVLVENPELIREVH 55 L+ L+ KQ L++DGA TEL+ + + + + P +++E+H Sbjct: 5 KEKLKDLIKKQ-YLIIDGATGTELQKKEIKKESWIINGNNIEGCNEILNITAPNIMKEIH 63 Query: 56 LDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQA-- 113 +DY A A T S+ A P + + + ++ L + +A +ARE YL Sbjct: 64 IDYLNANANITKTNSFGAIPWVLSEYDIAD-KTYELAKSAALIANEAREEYLKNPNSKGD 122 Query: 114 --GTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLP 171 + +AGS+GP G + S + + V L+D G D++ ET Sbjct: 123 LNRDIFIAGSLGP-------GVKLPSLGQISFDEMYNGYTEAVRGLIDGGVDIILLETAQ 175 Query: 172 NFSEIEALAELLTA-----YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALG 226 + ++++ + S T+ + GT + +L+ + ++G Sbjct: 176 DVLQLKSAILAVNDTAKKLNKEIPIMVSVTIEKEGTMLLGTDIETAYTILSNL-DIFSIG 234 Query: 227 INC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ 285 +NC + ++ L ++ LP+ ++ N+G + K + + + AD ++ Sbjct: 235 MNCGTGPDMAMRHIKKLSEISYLPISIHSNAGLPENRGGKAY--YSMTPEEFADINSKFF 292 Query: 286 AA-GARLIGGCCRTTPADIAALKAR 309 G IGGCC TTP I AL + Sbjct: 293 ELDGLAFIGGCCGTTPLHINALANK 317 >UniRef50_C9RQ92 Methionine synthase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RQ92_FIBSS Length = 1217 Score = 264 bits (675), Expect = 3e-69, Method: Composition-based stats. Identities = 58/330 (17%), Positives = 121/330 (36%), Gaps = 40/330 (12%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M+ + ++LLDG M + ++ G A+ + + +E PE+I ++ Y Sbjct: 1 MTLREAFES-----KMMLLDGGMGSVIQTYGIKGAN---NDMLSIEKPEIILDIQRRYVD 52 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AG C T ++ + E + + SV++A++A E + + G Sbjct: 53 AGVDCLTTNTFSSQRVSQHEYH-QEHRIAEMNRASVKIAKQAAEE--GFKKYGRKVYILG 109 Query: 121 SVGPYGAYLADGSE--YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 VGP L+ + + + + + ++ L++ G D + ET+ + +A Sbjct: 110 DVGPTSKMLSMSEDVNDPASRAITFDELEDAYLEQISVLMEEGVDAILIETIFDTLNAKA 169 Query: 179 LAEL----------LTAYPRAR--------AWFSFTLRD-SEHLSDGTPLRDVVALLAGY 219 S T+ D S G + + + Sbjct: 170 ALSAYSKANDARIEAAKAAGTPEAEIKPIEVMLSMTVSDASGRTLSGQTVEAFAVSVM-H 228 Query: 220 PQVVALGINC-IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLA 278 +++G+NC + + L+ + + L +PN+G + + + + Sbjct: 229 MHPLSIGLNCGLGADGMVPYLRRMGAIAPCYLSCHPNAGLP-----NQFGGYDDTPEDMV 283 Query: 279 DYLPQWQAAG-ARLIGGCCRTTPADIAALK 307 + + +IGGCC TTP IAA++ Sbjct: 284 RLMRVYLDDKLVNMIGGCCGTTPEHIAAMR 313 >UniRef50_A5TSW8 Methionine synthase n=9 Tax=Fusobacterium RepID=A5TSW8_FUSNP Length = 1082 Score = 264 bits (674), Expect = 4e-69, Method: Composition-based stats. Identities = 70/309 (22%), Positives = 113/309 (36%), Gaps = 25/309 (8%) Query: 13 KQDILLLDGAMATELEARGCNLADS----LWSAKVLVENPELIREVHLDYYRAGAQCAIT 68 K+ IL+LDGAM T L+ D + P++I EVH Y AGA T Sbjct: 9 KERILVLDGAMGTVLQKYELTPEDFNGAKGCYEILNETRPDIIFEVHKKYIEAGADIIET 68 Query: 69 ASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 S+ L E + L KS E+AR A + + V GS+GP Sbjct: 69 NSFNCNAISLKDYHL-EDKVYDLAKKSAEIARDAVKE------SGKKVYVFGSIGPTNKS 121 Query: 129 LA-DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYP 187 L+ + S + + + +V L+D G D + ET+ + +A Sbjct: 122 LSFPVGDVPYKRAVSFDEMKEVIKVQVAGLIDGGVDGILLETIFDGLTAKAALLATEEVF 181 Query: 188 R-----ARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQH 241 S T+ L G + ++A L V + G NC ++ + Sbjct: 182 EEKNVKLPISISATVNRQGKLLTGQSMESLIAAL-DRDSVTSFGFNCSFGAKDLVPLVIK 240 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQA-AGARLIGGCCRTTP 300 + LT + ++ N+G + E ++ D L ++GGCC T+ Sbjct: 241 IKELTTKFVSLHANAGLPNQNGD-----YVETAQKMRDDLLPLIENQAINILGGCCGTSY 295 Query: 301 ADIAALKAR 309 I A+ Sbjct: 296 DHIRAIAEM 304 >UniRef50_A7SKT1 Predicted protein n=4 Tax=Eumetazoa RepID=A7SKT1_NEMVE Length = 1178 Score = 264 bits (674), Expect = 4e-69, Method: Composition-based stats. Identities = 69/314 (21%), Positives = 116/314 (36%), Gaps = 41/314 (13%) Query: 17 LLLDGAMATELEARGCNLADSLW-------------SAKVLVENPELIREVHLDYYRAGA 63 ++ DG M T ++ AD + + + P+ I ++H Y AGA Sbjct: 1 MIFDGGMGTMIQKLHLEEADFRGEEFKNHPKSLKGNNDLLSITKPDAILDIHKGYLEAGA 60 Query: 64 QCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVG 123 T ++ T A GL E + L S E+A++A Y VAG++G Sbjct: 61 DFVETNTFSGTKIAQADYGL-EDAAYRLNRASAEVAKRAA--YEVTASTGVEKFVAGAMG 117 Query: 124 PYGAYLA--DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 P L+ E G + + + + + LLD G D+L ET+ + + +A Sbjct: 118 PTNRTLSISPTVECPGFRNVTFDELVDAYTEQARGLLDGGVDVLLVETIFDTANAKAALF 177 Query: 182 LL-----TAYPRARAWFSFT-LRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALEN 234 + Y + S T + S G V + + + +G+NC Sbjct: 178 AIDQLFEKEYSPVPVFVSGTIVDKSGRTLSGQTTESFVISV-SHSSPMCIGLNCALGAVE 236 Query: 235 TTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGG 294 ++ + T + YPN+G T+ + E +A +L AR Sbjct: 237 MRPFIEAVGMNTEAYTICYPNAGLP-----NTFGDYDETPETMAKHLK------AR---- 281 Query: 295 CCRTTPADIAALKA 308 CC TTP I A+ Sbjct: 282 CCGTTPEHIRAIAE 295 >UniRef50_A0APQ1 CG10623 protein n=22 Tax=Drosophila RepID=A0APQ1_DROME Length = 331 Score = 263 bits (673), Expect = 5e-69, Method: Composition-based stats. Identities = 111/316 (35%), Positives = 165/316 (52%), Gaps = 22/316 (6%) Query: 12 DKQDILLLDGAMATELEARGCNL--ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITA 69 D + IL+ G +++L D LW ++ NPE + + HLD+ R GA +T Sbjct: 10 DTKPILVKCGGFSSQLAKNVTEKVDGDPLWGSRFDATNPEAVIQTHLDFLRNGADIILTN 69 Query: 70 SYQATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQAGT---LLVAGSVGPY 125 +YQ++ GF G+ + LI KSV+LA++A+E YL+E L+ GS+GPY Sbjct: 70 TYQSSVEGFVKYLGVTRERGVELIQKSVQLAKQAKEQYLSEIGSEAESALPLIMGSIGPY 129 Query: 126 GAYLADGSEYRGDYH--CSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 GAYL DGSEY G+Y S E +A+H+ R+E L AG D LA ETLP E EA+ EL+ Sbjct: 130 GAYLHDGSEYTGNYADKLSKEELRAWHKTRIEICLAAGVDGLALETLPCLMEAEAVTELV 189 Query: 184 TA-YPRARAWFSFTLRDSEHLSDGTPLRDV-------VALLAGYPQVVALGINCIALENT 235 +P A+ W S D +H++ G + V +++ +G+NC+ Sbjct: 190 LDNFPDAKFWVSLQCMDEKHMASGENFAEAALSLWRLVQSRKAENRLLGIGLNCVNPLFV 249 Query: 236 TAALQHLHGLT---VLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLI 292 T L L + +PLVVY N GE YD W G ++ ++P+W G R++ Sbjct: 250 TPLLSSLTKVAGSDRIPLVVYSNRGEIYDVEQGDWTGTG---EEVVKFVPEWIQLGVRIV 306 Query: 293 GGCCRTTPADIAALKA 308 GGCCR P D+ A++ Sbjct: 307 GGCCRVYPTDVLAIRK 322 >UniRef50_C1EAX2 Predicted protein n=36 Tax=cellular organisms RepID=C1EAX2_9CHLO Length = 1378 Score = 263 bits (672), Expect = 7e-69, Method: Composition-based stats. Identities = 72/323 (22%), Positives = 132/323 (40%), Gaps = 31/323 (9%) Query: 11 LDKQDILLLDGAMATELEARGCNLADSLW-------------SAKVLVENPELIREVHLD 57 + K+ I+++DGAM T ++ + D + +++ P++I E+H Sbjct: 122 IMKERIMVIDGAMGTAVQKYKLSEDDFRGERYKNHTHDLKGNNDVLVITRPDVIEEIHTA 181 Query: 58 YYRAGAQCAITASYQATPAGFAARGLD-EAQSKALIGKSVELARKAREAYLAENPQAGTL 116 Y AGA T ++ +T A LD + + L + +LA+K + +NP Sbjct: 182 YLAAGADIIETNTFNSTMISQADYELDKKEEVYLLNKTAAQLAKKCCVEFTKKNPA-KPR 240 Query: 117 LVAGSVGPYGAYL--ADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFS 174 AG+VGP L + E C+ + + +VEAL+D G D+L ET+ + Sbjct: 241 FAAGAVGPTNKTLSVSPSVENPAFRGCTYDEIVEAYYEQVEALIDGGVDVLLVETIFDTL 300 Query: 175 EIEALAELLTAYPRA-----RAWFSFT-LRDSEHLSDGTPLRDVVALLAGYPQVVALGIN 228 +A + Y + S T + +S G + + + +A+G+N Sbjct: 301 NAKAAMFAIDMYFEKWGQKIPVFVSGTIVDNSGRTLSGQT-NEAFWNSMSHSKPIAIGLN 359 Query: 229 CI-ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAA 287 C ++ +++L + + YPN+G + + A++A+ + Sbjct: 360 CALGAKDMVPYIENLSRVADCWVFCYPNAGLPNAMGG-----YDQKGAEMAEDCRVFPEK 414 Query: 288 G-ARLIGGCCRTTPADIAALKAR 309 G IGGCC TT I L Sbjct: 415 GLINAIGGCCGTTDEHIKCLADM 437 >UniRef50_C5D740 Methionine synthase n=8 Tax=Bacteria RepID=C5D740_GEOSW Length = 1136 Score = 262 bits (671), Expect = 9e-69, Method: Composition-based stats. Identities = 78/318 (24%), Positives = 127/318 (39%), Gaps = 30/318 (9%) Query: 4 NNPLRALLDKQDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREVHLD 57 N L L+K+ IL++DGAM T +++ + D + + + P +I +H Sbjct: 3 NITLEQQLEKK-ILIIDGAMGTMIQSAKLSADDFGGEAYEGCNEYLTLTAPHVIERIHEA 61 Query: 58 YYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLL 117 Y +AGA T ++ AT L + L ++ LARKA +AY Sbjct: 62 YLQAGADIIETNTFGATNVVLDEYHLG-HLALELNIEAARLARKAADAYSTPEW---PRF 117 Query: 118 VAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE 177 VAGS+GP L+ + E A + + LL G DLL ET + ++ Sbjct: 118 VAGSMGPTTKTLSVTG------GITFEQLVAAYEEQARGLLLGGVDLLLLETCQDTLNVK 171 Query: 178 ALAELLTAY-----PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IA 231 A ++ + S T+ G + + + + A+G+NC Sbjct: 172 AGFIGISKAFEAVGKQVPIMISGTIEPMGTTLAGQTIESFFISV-QHMKPFAVGLNCATG 230 Query: 232 LENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG-AR 290 E T L+ L L + YPN+G + + E LA + ++ G Sbjct: 231 PEFMTDHLRALASLANTAVSCYPNAGLPDEEGC-----YHETPEMLAKKIRRFAEKGWIN 285 Query: 291 LIGGCCRTTPADIAALKA 308 ++GGCC TTP I A+ Sbjct: 286 IVGGCCGTTPEHIRAIAE 303 >UniRef50_B9W8L8 Homocysteine S-methyltransferase, putative (S-methylmethionine:homocysteine methyltransferase, putative) n=3 Tax=Candida RepID=B9W8L8_CANDC Length = 311 Score = 262 bits (670), Expect = 1e-68, Method: Composition-based stats. Identities = 105/313 (33%), Positives = 160/313 (51%), Gaps = 20/313 (6%) Query: 6 PLRALLDKQDILLLDGAMATELEAR------GCNLADSLWSAKVLVENPELIREVHLDYY 59 ++ LL+K+ L++DGA+ TELE + LWS +VL++NPEL+ +VHLDY Sbjct: 3 RVKDLLEKKK-LVIDGALGTELERLLPTTSTYLPSSSPLWSGQVLIKNPELVEQVHLDYI 61 Query: 60 RAGAQCAITASYQATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLV 118 AGA IT++YQ + A G D Q+ L ++++A+ A + +++ Sbjct: 62 NAGADMIITSTYQTSYASLHKYIGYDMDQAVTLWNSALDVAKSAVKK-----SGRDDVII 116 Query: 119 AGSVGPYGAYLADGSEYRGDY-HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE 177 AGS+GPY LA+GSEY GDY S + +H P E ++ D++ ET+P+F E++ Sbjct: 117 AGSIGPYATLLANGSEYNGDYQGVSDQELIEYHTPLFEFYNNSDVDIICIETIPSFQELK 176 Query: 178 ALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQV--VALGINCIALENT 235 + L Y + S + LSDGT L +V L A VA+GINC + EN Sbjct: 177 VIIGLTKKYTSKEFFISINPQTGSALSDGTSLTEVAQLFAEINDPRFVAVGINCTSYENV 236 Query: 236 TAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAA-GARLIGG 294 +L T P+ +YPN G YD + + A+ + +W + IGG Sbjct: 237 DQISTYL---TNFPIFIYPNLGFVYDTTVHKFVSKMLQESAWANSIAKWLNLPNVKAIGG 293 Query: 295 CCRTTPADIAALK 307 CC TTPA+I + Sbjct: 294 CCSTTPAEIQQVA 306 >UniRef50_Q49V93 Putative homocysteine S-methyltransferase n=1 Tax=Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 RepID=Q49V93_STAS1 Length = 301 Score = 262 bits (670), Expect = 1e-68, Method: Composition-based stats. Identities = 108/305 (35%), Positives = 161/305 (52%), Gaps = 12/305 (3%) Query: 6 PLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQC 65 L L Q L+LDG +AT LE GC+L SLWS++VL NP I++ H + GA Sbjct: 2 RLLEKLKAQSPLVLDGGLATTLEQAGCSLKTSLWSSEVLKNNPTQIKQAHQAFTDVGADI 61 Query: 66 AITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY 125 +T++YQA+ F+ G+ + L +V +A T ++ GS+GPY Sbjct: 62 LLTSTYQASYQTFSDIGMKATEIDQLYNTAVNQIMEA---------TTDTQVIVGSLGPY 112 Query: 126 GAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE-LLT 184 GAYL+DGSEY G Y S E + FH+ R+EAL+ G + ET+PNF EI+A+ E ++ Sbjct: 113 GAYLSDGSEYTGAYDLSKEDYFQFHKTRIEALVKRGINDFVFETVPNFEEIKAIVEYIVP 172 Query: 185 AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQ-VVALGINCIALENTTAALQHLH 243 Y W S T+ + LSD T + A + Y + + GINC ++ A+ Sbjct: 173 HYTNQTFWLSVTVNEDGDLSDDTEFEKLCAYIKQYAERIPVFGINCSSVAGINKAISKGL 232 Query: 244 GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADI 303 + +YPN G Y+AV K W G + + + +P W G ++IGGCC+TTP +I Sbjct: 233 KNVPQTIALYPNGGAQYNAVEKEWESVG-NQGLIVEQIPGWLDQGVKIIGGCCQTTPENI 291 Query: 304 AALKA 308 ++K Sbjct: 292 KSIKE 296 >UniRef50_Q5N5P4 5-methyltetrahydrofolate--homocysteine methyltransferase n=16 Tax=Cyanobacteria RepID=Q5N5P4_SYNP6 Length = 1190 Score = 262 bits (669), Expect = 1e-68, Method: Composition-based stats. Identities = 75/316 (23%), Positives = 125/316 (39%), Gaps = 28/316 (8%) Query: 7 LRALLDKQD-ILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREVHLDYY 59 L L + +L+ DG M T L+ + D + ++ PE I VH + Sbjct: 6 LDRLHSPERPVLVFDGGMGTTLQFQNLTAEDFGGPETEGCNEWLIRTKPEAIATVHRQFL 65 Query: 60 RAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVA 119 AGA T ++ AT A GL++ + AL VE A+ A+ + VA Sbjct: 66 EAGADVIETDTFGATTIVLAEYGLEDH-AYALN---VEAAKLAKAIAAEFSTPEKPRFVA 121 Query: 120 GSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEAL 179 GS+GP H + +A + L + G DL ET + +I+A Sbjct: 122 GSMGPTTKL-------PTLGHIGYDEMKASFAEQARGLWEGGVDLFIVETCQDVLQIKAA 174 Query: 180 AELLTAY-----PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALE 233 + R S T+ + + G+ + ++A+L YP + LG+NC + Sbjct: 175 LNGIAEIFSEKGDRRPLMVSVTMETTGTMLVGSDVAAMLAILEPYP-IDILGLNCATGPD 233 Query: 234 NTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQA-AGARLI 292 +++L + + PN+G + H+ +L L ++ G ++I Sbjct: 234 RMVEHIKYLSEHSPFVISCIPNAGIPENVGGHA--HYRLTPMELRMALHRFVEDLGVQVI 291 Query: 293 GGCCRTTPADIAALKA 308 GGCC T P IA L Sbjct: 292 GGCCGTKPEHIAQLAE 307 >UniRef50_B2UNQ8 Methionine synthase n=1 Tax=Akkermansia muciniphila ATCC BAA-835 RepID=B2UNQ8_AKKM8 Length = 1253 Score = 261 bits (668), Expect = 2e-68, Method: Composition-based stats. Identities = 77/359 (21%), Positives = 136/359 (37%), Gaps = 58/359 (16%) Query: 2 SQNNPLRALLD--KQDILLLDGAMATELEA--------RGCNLADSLW--------SAKV 43 S+ L L D ++ +++LDGAM T ++ RG AD+ + + Sbjct: 5 SRTERLDYLKDQLRKRVVILDGAMGTNIQKFRLGEGDYRGERFADAECYPNDLKNNNDLL 64 Query: 44 LVENPELIREVHLDYYRAG-AQCAITASYQATPAGFAARGLDEAQ--------------- 87 ++ P++I ++H + G T ++ AT G + Sbjct: 65 VLTRPDIILDIHRRFLDTGRTDILETCTFGATSIGQHDYFWHRPEEGSHKDQQYFQEVVD 124 Query: 88 -------SKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY--LADGSEYRGD 138 + L + LAR+A + AE LVAGS+GP L+ G Sbjct: 125 APELKALVRELNLAAAALARQACDE--AEAADGKPRLVAGSIGPMPVTCSLSPDVNDPGF 182 Query: 139 YHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY------PRARAW 192 + + +R +V ALL+ G D+L ET+ + +A + Sbjct: 183 RAVNFRQLRQAYRDQVLALLEGGVDMLLVETIFDTLNAKAALFAIEEIFEEQPESSVPVM 242 Query: 193 FSFTLRD-SEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPL 250 S TL D + G + + + + ++GINC + + L GL + Sbjct: 243 VSVTLTDKAGRTLSGQTI-EAFWNSIRHVRPFSVGINCALGPDLMRPFAEELSGLADCHM 301 Query: 251 VVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG-ARLIGGCCRTTPADIAALKA 308 +Y N+G + + A +A ++ ++ G ++GGCC TTP I A+ A Sbjct: 302 SIYANAGLP---NPLSPTGYDLLPADMARFMKEYAEQGLLNIVGGCCGTTPEHIGAIAA 357 >UniRef50_Q9VJ32 CG10621 n=19 Tax=Neoptera RepID=Q9VJ32_DROME Length = 331 Score = 261 bits (668), Expect = 2e-68, Method: Composition-based stats. Identities = 120/317 (37%), Positives = 166/317 (52%), Gaps = 25/317 (7%) Query: 15 DILLLDGAMATELEARGCNL--ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 +L+ DG T++ + D LWSA+ NP I HLD+ + GA +T +YQ Sbjct: 5 RVLVKDGGFGTQMTVHVGDSVDGDPLWSARFNATNPAAIISTHLDFLQNGADIILTNTYQ 64 Query: 73 ATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAE------NPQAGTLLVAGSVGPY 125 ++ G+ LDE QS LI +V LA A+E YL E + Q G L+ S+GP+ Sbjct: 65 SSVDGYMEYLELDEEQSIELIKNTVRLAHIAKERYLTECYQAQLSVQEGYPLIIASIGPF 124 Query: 126 GAYLADGSEYRGDYH--CSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 GA+L DGSEY G Y + +HR R+EA L+AG D LA ET+P E EAL E+L Sbjct: 125 GAHLHDGSEYTGSYADFVPAKEITDWHRVRIEACLEAGVDALAIETIPCQMEAEALVEML 184 Query: 184 -TAYPRARAWFSFTLRDSEHLSDGTPLRDVVALL-------AGYPQVVALGINCIALENT 235 YP + W +F +D L+ G D + + +A+G+NC+ + Sbjct: 185 CDDYPDVKFWVAFQCKDENTLAHGETFADAANAIWDLLAERNAQDKCLAIGVNCVHPKFV 244 Query: 236 TAALQHLHGLTVL----PLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARL 291 T + L+G + PLVVYPNSGE YD V W EHC LA+Y+P+W GA++ Sbjct: 245 TPLFKSLNGDREVGEQIPLVVYPNSGEVYDVV-NGWQGR-EHCVPLANYVPEWAQLGAKV 302 Query: 292 IGGCCRTTPADIAALKA 308 IGGCCRT DI + Sbjct: 303 IGGCCRTYARDIRHIGE 319 >UniRef50_A9FZY9 Methylenetetrahydrofolate reductase n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9FZY9_SORC5 Length = 624 Score = 261 bits (668), Expect = 2e-68, Method: Composition-based stats. Identities = 87/311 (27%), Positives = 127/311 (40%), Gaps = 24/311 (7%) Query: 1 MSQNNPLRALLD--KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDY 58 MS+ P LD ++ IL+ DGAM + L RG + + ++ V P+L++++H +Y Sbjct: 4 MSRTRPEAPFLDALRRSILVFDGAMGSLLYERGVFVTQNF--EQLNVARPDLVKKIHAEY 61 Query: 59 YRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLV 118 AGA T ++ A GL + + LAR+ G V Sbjct: 62 VAAGANVIETNTFGANRFRLERYGL-VNEVRNFNLAGARLAREIA---------GGDAYV 111 Query: 119 AGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 AGS+GP G L G R D A A + AL + GADLL ET + EI+ Sbjct: 112 AGSIGPTG--LVPGVATRDDLA----AASATFAEQAGALAEGGADLLILETFRHLDEIKL 165 Query: 179 LAELLT-AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTA 237 + A P S T S +DG+ V L + V LG+NC + Sbjct: 166 AIDAARSAAPGLPVLASMTFDTSGVAADGSEPERVARTLRDW-GVELLGVNCGDGPQLSL 224 Query: 238 ALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCR 297 A+ LPL V PN+G + + + + AGA +IGGCC Sbjct: 225 AMAERMATAGLPLCVQPNAGLPRTVDGR--QLYMATPEYFDVFARRMIQAGAAMIGGCCG 282 Query: 298 TTPADIAALKA 308 TTP + + Sbjct: 283 TTPEHVRWMAK 293 >UniRef50_B0TAJ7 Methionine synthase, putative n=1 Tax=Heliobacterium modesticaldum Ice1 RepID=B0TAJ7_HELMI Length = 807 Score = 261 bits (667), Expect = 2e-68, Method: Composition-based stats. Identities = 72/289 (24%), Positives = 106/289 (36%), Gaps = 22/289 (7%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 I L DGAM T L+A G + +E+PE + +H Y GA+ T ++ AT Sbjct: 2 IKLFDGAMGTMLQAAGLLPG--ACPERFNLEHPERVTAIHRRYVEMGAEIIETNTFGATR 59 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 A + + A A +AGSVGP G +A E Sbjct: 60 LKLAHYRMADQVE----------AVCHAAVRAARAACGPATKIAGSVGPTGKLIAPLGE- 108 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 S E + ++ AL G D + ET+ + E+ A A + Sbjct: 109 -----LSFEEAVDVYSEQISALAAVGVDYILIETIIDIQEMRAALLAAKAVAKVPVICQL 163 Query: 196 TLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLVVYP 254 + GT LL +G+NC ++ + G T LP+ P Sbjct: 164 SFGADGRTVTGTDPATAAYLLEAM-GADVIGVNCSLGPAQLLPVIEAIAGATNLPISAQP 222 Query: 255 NSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADI 303 N+G +T + A + P+ AAGA +GGCC TTP I Sbjct: 223 NAGMPELIDGRTV--FPMSPEEFASWAPKLAAAGATYLGGCCGTTPEHI 269 >UniRef50_A7VWF8 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753 RepID=A7VWF8_9CLOT Length = 408 Score = 260 bits (666), Expect = 3e-68, Method: Composition-based stats. Identities = 71/293 (24%), Positives = 123/293 (41%), Gaps = 23/293 (7%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 L+LDGA T L A G + + ++E+PE + + + AG+ + ++ A Sbjct: 8 PLILDGATGTNLIAAGMPSG--VCVEQWILEHPEKLLALQRAFLEAGSNAVMAPTFGANR 65 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 AA GL + Q + + K V L+++A E + LV G V P G + + Sbjct: 66 EKLAAYGLQD-QVEEINLKLVALSKEAAEPF--------HALVGGDVSPAGVMIEPYGD- 115 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 + + + ++ AL AG D +A ET + +++ A + + Sbjct: 116 -----LTFDELYDIYLEQIRALKKAGVDFIALETQMSLADLRAGVLAAKEA-GLPVFATI 169 Query: 196 TLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLVVYP 254 T+ D+ GT V+ L A+G+NC E L+ +PL+ P Sbjct: 170 TVEDNGRTIMGTKFLPVLITLQALGAA-AVGLNCSTGPEVMEELLEGAVSHAQVPLIAKP 228 Query: 255 NSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 N+G+ + A+ A+ + AAGA+++GGCC +TP I L Sbjct: 229 NAGKPSQEDPAV---YPLSPAEFAEKMESLLAAGAQIVGGCCGSTPEHIRELA 278 >UniRef50_Q49775 Methionine synthase n=41 Tax=Bacteria RepID=METH_MYCLE Length = 1206 Score = 260 bits (665), Expect = 4e-68, Method: Composition-based stats. Identities = 64/306 (20%), Positives = 121/306 (39%), Gaps = 25/306 (8%) Query: 14 QDILLLDGAMATELEARGCNLAD----SLWSAKVLVENPELIREVHLDYYRAGAQCAITA 69 Q +++ DGAM T+L+ L D + + P+++ +H Y+ AGA T Sbjct: 21 QRVMVGDGAMGTQLQDAELTLDDFRGLEGCNEILNETRPDVLETIHRRYFEAGADLVETN 80 Query: 70 SYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYL 129 ++ + + + + + L + +AR+ + V GS+GP Sbjct: 81 TFGCNLSNLGDYDIAD-KIRDLSQRGTVIARRVADELTTP---DHKRYVLGSMGP----- 131 Query: 130 ADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA-----ELLT 184 G++ H + + +LD GAD + ET + +++A + Sbjct: 132 --GTKLPTLGHTEYRVVRDAYTESALGMLDGGADAVLVETCQDLLQLKAAVLGSRRAMTQ 189 Query: 185 AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLH 243 A + T+ + + G+ + +A + V +G+NC + L+HL Sbjct: 190 AGRHIPVFVHVTVETTGTMLLGSEIGAALAAVEPL-GVDMIGLNCATGPAEMSEHLRHLS 248 Query: 244 GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW-QAAGARLIGGCCRTTPAD 302 +P+ V PN+G + + +LA+ L + G L+GGCC TTP Sbjct: 249 KHARIPVSVMPNAGLP--VLGAKGAEYPLQPDELAEALAGFIAEFGLSLVGGCCGTTPDH 306 Query: 303 IAALKA 308 I + A Sbjct: 307 IREVAA 312 >UniRef50_B7GLS5 Methionine synthase I containing methyltransferase and cobalamin-binding domains n=1 Tax=Anoxybacillus flavithermus WK1 RepID=B7GLS5_ANOFW Length = 1142 Score = 260 bits (665), Expect = 5e-68, Method: Composition-based stats. Identities = 75/320 (23%), Positives = 125/320 (39%), Gaps = 31/320 (9%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREVH 55 + + L ++ IL++DGAM T ++A D + + + P +I +H Sbjct: 13 TMASLFAQL--EKKILIIDGAMGTMIQAANLTADDFGGEAYEGCNEYLTLTAPHVISHIH 70 Query: 56 LDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGT 115 Y+ AGA T ++ AT L + L ++ +LA++A E Y Sbjct: 71 EAYFAAGADIVETNTFGATRIVLDEYNLG-HLALELNMEAAKLAKRAAEKYT---TSDHP 126 Query: 116 LLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE 175 VAGS+GP L+ + + + + LL G DLL ET + Sbjct: 127 RFVAGSMGPTTKTLSVTG------GATFAELISSYEEQARGLLLGGVDLLLLETCQDTLN 180 Query: 176 IEALAELLTAY-----PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC- 229 ++A +T + S T+ G + + + + A+G+NC Sbjct: 181 VKAAFLGITKAFQAVGKQVPLMISGTIEPMGTTLAGQTIESFFISV-QHMKPFAIGLNCA 239 Query: 230 IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG- 288 E T L+ L L + YPN+G + H+ E LA + Q+ G Sbjct: 240 TGPEFMTDHLRSLASLANTAVSCYPNAGLPDEEG-----HYHETPEMLAKKIRQFAEKGW 294 Query: 289 ARLIGGCCRTTPADIAALKA 308 ++GGCC TTP I A+ Sbjct: 295 LNIVGGCCGTTPQHIQAIAE 314 >UniRef50_UPI000196BD90 hypothetical protein CATMIT_02259 n=1 Tax=Catenibacterium mitsuokai DSM 15897 RepID=UPI000196BD90 Length = 791 Score = 259 bits (661), Expect = 1e-67, Method: Composition-based stats. Identities = 66/298 (22%), Positives = 118/298 (39%), Gaps = 23/298 (7%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 + L K+ L DG + L++ G + + +PE I E++ Y AG Sbjct: 3 FKERLTKE-WLFWDGGTGSVLQSWGLQAGE--LPETWNIIHPEKIVELNKGYLEAGCDII 59 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 T ++ A + + ++ K+VE A+KARE L+A +GP G Sbjct: 60 NTNTFGANRLKYPDN------LEEIVTKAVEHAKKARELTGRA-----DALIALDLGPTG 108 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 L + S + + +E AGAD++ ET+ + E++A + Sbjct: 109 KLLEPLGD------LSFDDAVDIYAEVIEYGTKAGADVILIETMQDSYELKAAVLAAKEH 162 Query: 187 PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGL 245 + + + G VVALL G + ALGINC ++ + + Sbjct: 163 SDLPVCATVVFDEKGKMLTGGTPESVVALLEGLH-IDALGINCSLGPRQIKPFVERMIQV 221 Query: 246 TVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADI 303 + P++V PN+G + ++ A + + + ++GGCC TTP + Sbjct: 222 SSTPIIVTPNAGLPQ-TDDEGHTYYDMSADDFALEMKEIASLNVHVLGGCCGTTPEYL 278 >UniRef50_D2RMA2 Homocysteine S-methyltransferase n=13 Tax=Bacteria RepID=D2RMA2_ACIFE Length = 805 Score = 258 bits (660), Expect = 2e-67, Method: Composition-based stats. Identities = 77/301 (25%), Positives = 116/301 (38%), Gaps = 20/301 (6%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 L + L DGAM T L+ G + + +PE +R +H Y RAG Sbjct: 3 FTEALHTRR-LFFDGAMGTMLQEAGLQPGE--LPETWNLLHPEKVRAIHQAYVRAGVDIL 59 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 T ++ A F A + + + L+ VE AR A + VA +GP G Sbjct: 60 KTNTFGANGLKFGAAH-GQPEVEELVRAGVENARAAFA------AEVRDGFVALDLGPTG 112 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 L + A + +V+A AGADL+ ET+ + E +A Sbjct: 113 KLLQPFGDLP------FAEAVALYAAQVKAGAAAGADLILIETMSDSYEAKAAILAAKEN 166 Query: 187 PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGL 245 +FT + L +G + + ++A V A+G NC + + Sbjct: 167 ADLPIVCTFTFDEDGKLLNGADVTTAL-VMAESLGVSAVGFNCGQGPDTLVKLVPQALQA 225 Query: 246 TVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAA 305 +PLV PN+G KT H A + + AG ++GGCC TTP IA Sbjct: 226 VDIPLVANPNAGLPVQKDGKTVFHIDG--EGYAPLMVPFAEAGVSVLGGCCGTTPDHIAR 283 Query: 306 L 306 L Sbjct: 284 L 284 >UniRef50_A1AKP7 Methylenetetrahydrofolate reductase n=10 Tax=Desulfuromonadales RepID=A1AKP7_PELPD Length = 615 Score = 258 bits (660), Expect = 2e-67, Method: Composition-based stats. Identities = 85/297 (28%), Positives = 125/297 (42%), Gaps = 21/297 (7%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K ++L DGA+ T L ARG L S ++ + P L+RE+ DY AGAQ T ++ Sbjct: 8 KGEVLTGDGALGTMLYARGVGLDSSF--EQLNLTRPALVRELADDYVAAGAQVIETNTFG 65 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A AA GL E + + +AR+A + Q +LVAGSVGP D Sbjct: 66 ANYTRLAALGL-EQRVWEINLAGARIARQAAD-------QGRDVLVAGSVGPLPRIRGDE 117 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 +E E R + +AL + G DLL ET + +++ A + Sbjct: 118 AES------DQERMAELFRVQCQALAEGGVDLLLLETFSSLTQLAAAVQAAR-CTGLTVA 170 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLV 251 S + +DG + + A + +G NC ++ L +T P+ Sbjct: 171 ASMAFLEGGRSADGATVEEFCAAME-RAGADLVGANCGAGPLELVKVVRRLAAVTHKPIT 229 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 Y NSG + + LA + AAGA L+GGCC TTP IAA+ Sbjct: 230 AYANSGFPEYHDGR--FIYRATPEYLATMAGELVAAGASLVGGCCGTTPEHIAAISR 284 >UniRef50_D1Y627 Homocysteine S-methyltransferase n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y627_9BACT Length = 798 Score = 258 bits (659), Expect = 2e-67, Method: Composition-based stats. Identities = 65/292 (22%), Positives = 122/292 (41%), Gaps = 23/292 (7%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 +++ DGAM T L+ +G L + + V P+LI +H +Y+ AG T ++ A Sbjct: 7 RVVMFDGAMGTMLQKKGLKLRE--IPESLNVSRPDLIESIHREYFAAGCDFVQTNTFGAN 64 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 P +++ +IG +V++AR+A +A+ + + VGP G +A + Sbjct: 65 PYKLEGTAY---ETEQVIGAAVKIARRAADAFSGKG-------ILLDVGPSGRAMAPVGD 114 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 + +V A + D + ET + E +A A + + Sbjct: 115 ------ADFDEIYGSVARQVRAGAEL-CDGILLETFTDLLEAKASALAALENSDKPVFLT 167 Query: 195 FTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLVVY 253 + ++ GTP+ ++ G + LG+NC ++ L + +P++V Sbjct: 168 MSFQEDGRTFFGTPVEAMIMTFEGL-GLSGLGVNCSLGPAQLAPIVKKLTAHSRVPVIVQ 226 Query: 254 PNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAA 305 PN+G + A++L Q+ G +GGCC TTP ++A Sbjct: 227 PNAGLPVVRDG--VSGWDVSPGEFANWLGQFVDWGTAFVGGCCGTTPEFLSA 276 >UniRef50_A5UPF4 Methionine synthase (B12-dependent) n=5 Tax=Chloroflexaceae RepID=A5UPF4_ROSS1 Length = 1254 Score = 257 bits (658), Expect = 3e-67, Method: Composition-based stats. Identities = 75/309 (24%), Positives = 133/309 (43%), Gaps = 22/309 (7%) Query: 13 KQDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREVHLDYYRAGAQCA 66 ++ +L+ DGAM T ++ AD +++ P++I ++H + AGA Sbjct: 55 RERVLIYDGAMGTSIDTFHLTAADYGGENTFGARDYLVMTRPDVIEQIHTSFLEAGADVL 114 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 T ++Q+T GL + Q+ A+ + LAR+ +A+ E VAGS+GP G Sbjct: 115 ETCTFQSTRIRLEEWGLAD-QTHAINVAAARLARRVADAF--EARDGRPRYVAGSMGPTG 171 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 S+ + + + AL++ G D+L ET + E++A + + Sbjct: 172 KL--PSSDDPSLSDITFDQLSDIFYEQAVALIEGGVDVLLVETSVDILEVKAALDGIRRA 229 Query: 187 ------PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAAL 239 P L S + GT + +VA L P V +G+NC E+ A+ Sbjct: 230 KADLNRPDVAVQAQVFLDLSGKMLLGTEVPALVATLEAMP-VDVIGLNCSTGPEHMREAI 288 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ-AAGARLIGGCCRT 298 +++ + P+ PN+G + +T + A L ++ G ++GGCC T Sbjct: 289 RYMTRHSRKPISCIPNAGLPIEVNGETV--YPMEPEPFARILGEYVHEYGVAVVGGCCGT 346 Query: 299 TPADIAALK 307 PA I L+ Sbjct: 347 RPAHIRRLR 355 >UniRef50_C4GEB2 Putative uncharacterized protein n=1 Tax=Shuttleworthia satelles DSM 14600 RepID=C4GEB2_9FIRM Length = 841 Score = 257 bits (657), Expect = 3e-67, Method: Composition-based stats. Identities = 72/298 (24%), Positives = 113/298 (37%), Gaps = 22/298 (7%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 I++LDG M T L+A G ++PE++ ++H Y AG+ ++ Sbjct: 2 DNKIIVLDGGMGTMLQAAGMPAGQH--PEVFGHQHPEIVEQIHRQYIEAGSNVIYANTFG 59 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A +D GK+V A + + + + + VA +GP G L Sbjct: 60 ANARKLQGCSID-------TGKAVFSAIRTAKRAAQKAAKET-VRVALDLGPVGELLEPL 111 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 S E +R V A +AGADL+ ET + +I+AL W Sbjct: 112 GT------LSFEEAYEIYREAVVAGYEAGADLIVAETFTDLLDIKALVLAAKENTPLPVW 165 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLV 251 + T S GT + + L G V A+GINC ++ L T LP++ Sbjct: 166 TTMTFERSGRTFTGTTIASMALTLTGL-GVDAIGINCSLGPTEILPLIEELREWTHLPVI 224 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKAR 309 PN+G + + + G ++GGCC T P I L +R Sbjct: 225 AKPNAGLPDPRTG----VYDLTAEDFGKQMQAYAELGVSVLGGCCGTDPDYIRCLVSR 278 >UniRef50_Q5ZBZ6 Os01g0772900 protein n=3 Tax=Magnoliophyta RepID=Q5ZBZ6_ORYSJ Length = 328 Score = 257 bits (657), Expect = 3e-67, Method: Composition-based stats. Identities = 124/303 (40%), Positives = 168/303 (55%), Gaps = 40/303 (13%) Query: 18 LLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPAG 77 ++DG +ATELEA G +L D LWSA LV P LIR+VHLDY AGA +ASYQAT G Sbjct: 26 VVDGGLATELEAHGADLHDELWSASCLVSAPHLIRKVHLDYLDAGANIITSASYQATIQG 85 Query: 78 FAARGLDEAQSKALIGKSVELARKAREAYLA----------ENPQAGTLLVAGSVGPYGA 127 F ARGL +S+AL+ +SV +A++AR + + +LVA S+G YGA Sbjct: 86 FQARGLSRERSEALLRRSVHIAQEARAIFAEGWSKGPYANHRSSPRRPVLVAASIGSYGA 145 Query: 128 YLADGSEYRGDYHCS--VEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA 185 YLADGSEY GDY S E ++FHR R++ L DAG DL+A ET+PN E +A Sbjct: 146 YLADGSEYTGDYGISVTKETLKSFHRRRLQVLADAGPDLIAFETIPNKLEAQA------- 198 Query: 186 YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL 245 G P+ + A+ +V A+G+NC A + + + Sbjct: 199 -------------------SGDPITECAAVADACARVGAVGVNCTAPRLVHGLILSIRKV 239 Query: 246 TVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQ--LADYLPQWQAAGARLIGGCCRTTPADI 303 T P+VVYPNSGE Y A +K W ++ + +W+ AGA L+GGCCRT+PA + Sbjct: 240 TSKPVVVYPNSGETYVAETKEWVESEGGASETDFVSCVGKWRQAGAALVGGCCRTSPATV 299 Query: 304 AAL 306 A+ Sbjct: 300 RAI 302 >UniRef50_B8J7W9 Methionine synthase n=3 Tax=Anaeromyxobacter RepID=B8J7W9_ANAD2 Length = 1150 Score = 257 bits (657), Expect = 4e-67, Method: Composition-based stats. Identities = 69/314 (21%), Positives = 121/314 (38%), Gaps = 22/314 (7%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNL----ADSLWSAKVLVENPELIREVHLDYYRAG 62 R L++ L+ DGAM T+++ + + + P+LI E+H Y+ G Sbjct: 3 FREALER-RPLVFDGAMGTQIQRHQLTAAEFGGKEGANDLLTLTRPDLIEEIHARYFAVG 61 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 T ++ ++ GL ++ + A AR A + VAGS+ Sbjct: 62 CDVVETNTFGSSRLKLDEYGLG-HRTYEVN---CRAAILARRAADRYSTPDHPRFVAGSI 117 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G + S + + +A + + + L++ G D L ET + E+ A Sbjct: 118 GPTG--MLPSSSDPALGNITSDALERIFFEQAKGLVEGGVDALIIETQQDMLELRAAVLA 175 Query: 183 L-----TAYPRARAWFSFT-LRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENT 235 A T + + + GT + VA L P V A+G+NC + Sbjct: 176 CDAVRREALRDVFVIAQPTLIDANGRMLLGTDIGSAVATLERLP-VDAVGLNCSTGPDEM 234 Query: 236 TAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQ-AAGARLIGG 294 A+++ L + V PN+G + + + LA L + G ++GG Sbjct: 235 RASVKALAEKCSHFVSVLPNAGMPENVDGRAV--YKLSPDDLARALVGFVAEYGVDIVGG 292 Query: 295 CCRTTPADIAALKA 308 CC TTP + + Sbjct: 293 CCGTTPEHLRKVVE 306 >UniRef50_Q55786 Methionine synthase n=14 Tax=Cyanobacteria RepID=METH_SYNY3 Length = 1195 Score = 257 bits (657), Expect = 4e-67, Method: Composition-based stats. Identities = 75/320 (23%), Positives = 128/320 (40%), Gaps = 27/320 (8%) Query: 3 QNNPLRALLD--KQDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREV 54 + + + +L+ DGAM T L+ + AD + ++ PE + V Sbjct: 1 MKSAFLDRIHSPDRPVLVFDGAMGTNLQVQNLTAADFGGAEYEGCNEYLVHTKPEAVATV 60 Query: 55 HLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAG 114 H +Y AGA T ++ TP A L + QS L + E A+ + Sbjct: 61 HRAFYEAGADVVETDTFGGTPLVLAEYDLAD-QSYYLNKAAAE---LAKAVAAEFSTPEK 116 Query: 115 TLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFS 174 VAGS+GP G++ H ++ + + +V L D G DLL ET + Sbjct: 117 PRFVAGSMGP-------GTKLPTLGHVDYDSLKDAYVVQVRGLYDGGVDLLLVETCQDVL 169 Query: 175 EIEALAELLTAY-----PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC 229 +I+A + R S T+ + GT + +A+L YP + LG+NC Sbjct: 170 QIKAALNAIEQVFAEKGDRLPLMVSVTMETMGTMLVGTEMAAALAILEPYP-IDILGLNC 228 Query: 230 -IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG 288 + +++L + + PN+G + + ++ Q+ + + G Sbjct: 229 ATGPDLMKEHVKYLSEHSPFVVSCIPNAGLPENVGGQAFYRLTPMELQM-SLMHFIEDLG 287 Query: 289 ARLIGGCCRTTPADIAALKA 308 ++IGGCC T P I AL Sbjct: 288 VQVIGGCCGTRPDHIKALAD 307 >UniRef50_Q2LQ11 Methylenetetrahydrofolate reductase n=1 Tax=Syntrophus aciditrophicus SB RepID=Q2LQ11_SYNAS Length = 618 Score = 256 bits (655), Expect = 6e-67, Method: Composition-based stats. Identities = 87/307 (28%), Positives = 127/307 (41%), Gaps = 24/307 (7%) Query: 5 NPLRALLDKQD--ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 + L+ +L + L+ DGAM T + +G + ++ + P LI +H Y +AG Sbjct: 2 SALQNVLSRMTGTPLIFDGAMGTMIYEKGVFIQT--CYDELCLTEPGLILGIHEQYAQAG 59 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 AQ T S+ A A GL E + + A LA TL VAGSV Sbjct: 60 AQVLETNSFGANRIKLRAYGLAE-KVADINRA---------AARLARQAAGTTLYVAGSV 109 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G G VEA R ++EAL + G DLL ET + E++ A + Sbjct: 110 GPCT---QGGQVITGRDMAEVEAA---FREQMEALTEEGVDLLLLETFSDLKELQLAARV 163 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 SF + D + GTP + A L P V +G+NC AL Sbjct: 164 ARE-RGVPVLASFAVDDDGETAAGTPAEKMAAALEKDPHVDVIGLNCGTGPAGIYEALLK 222 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 + + P++V PN+G + +T + + +Y ++ G R IGGCC PA Sbjct: 223 VLPVAGKPVIVMPNAGMPREIGGRT--LYLANPEYFTEYAKKFIELGVRGIGGCCGVHPA 280 Query: 302 DIAALKA 308 IA Sbjct: 281 HIATAAR 287 >UniRef50_Q1IQK2 Methionine synthase (B12-dependent) n=40 Tax=cellular organisms RepID=Q1IQK2_ACIBL Length = 407 Score = 255 bits (652), Expect = 1e-66, Method: Composition-based stats. Identities = 65/356 (18%), Positives = 129/356 (36%), Gaps = 55/356 (15%) Query: 1 MSQ--NNPLRALLDKQDILLLDGAMATELEARGC-----------NLADSLWS--AKVLV 45 M + +P+ +L+ I ++DGAM T + G + + L + + Sbjct: 39 MKRPDQHPIERILED-RIAIIDGAMGTTIRTYGMAEADIRGERFKDSSKGLLNNGDLFSL 97 Query: 46 ENPELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQ------------------ 87 P++I ++H + AGA T ++ AT + +D+ + Sbjct: 98 TQPQMIGDIHRRFLEAGADIIETNTFGATSIVQSEFFVDDPREHGGRKDADFYQKIIDDQ 157 Query: 88 -----SKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLA--DGSEYRGDYH 140 + + S + R+ + N + VAG++GP L+ ++ G Sbjct: 158 FLGDLAWEINETSAQQCREWADRVA--NATSRPRFVAGALGPLTVSLSNSPDADDPGFRV 215 Query: 141 CSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY-----PRARAWFSF 195 + + + + +V AL+ G D L ET+ + +A + S Sbjct: 216 VTFDQVKIAYIQQVRALIAGGVDFLLVETIFDSLNAKAALVAIREVFDQDGKNIPVMISA 275 Query: 196 TLRDSE-HLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLVVY 253 + + G + + + + +++G+NC + L+ L + + Y Sbjct: 276 AVGRGGETMISGQTV-EAFWNAVSHVKPLSVGLNCSLGPDLMYPFLEDLSAKADVAISCY 334 Query: 254 PNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG-ARLIGGCCRTTPADIAALKA 308 PN+G +A YL ++ AG + GGCC TP IAA+ Sbjct: 335 PNAGLP---NPLAATGFDFGPPDMARYLREFAEAGLINIAGGCCGNTPEHIAAIAK 387 >UniRef50_C0QE32 Methionine synthase I, cobalamin-binding domain protein n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QE32_DESAH Length = 294 Score = 254 bits (650), Expect = 2e-66, Method: Composition-based stats. Identities = 76/301 (25%), Positives = 123/301 (40%), Gaps = 21/301 (6%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K LL DG M + L ARG D+ + + PE I+EVH YY+AGA A T ++ Sbjct: 8 KTRGLLFDGGMGSMLIARGLQGGDA--PERWNLTRPEAIQEVHQAYYKAGADMATTNTFG 65 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A+ A + E + + V++A+ A+E + +AG +G G LA Sbjct: 66 ASAIKLAKMAVTEG-MEEINRAGVKVAKDAKEVW------GPGKFIAGDIGEAGDMLAPM 118 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 S E QA + + E L AG D+ ET + + A + + Sbjct: 119 G------PLSQEDAQACFKEQAEVLAHAGVDIFIIETQFDLNMALAAIRGIRSVTDIPIA 172 Query: 193 FSFTLRDSEH---LSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVL 248 + T + + G P + + LAG +G NC + + Sbjct: 173 CTMTFKQTPKGFFTIMGNPPAESMKTLAG-EGAFVVGANCSMGSDTMVELAGVIRDAVDT 231 Query: 249 PLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 P+++ PN+G +T + E AD + + ++ G ++GGCC TTP I + Sbjct: 232 PVMIQPNAGMPQAGPDQTVT-YPETADFFADNIMKMKSLGIEVVGGCCGTTPDYIRTIHD 290 Query: 309 R 309 R Sbjct: 291 R 291 >UniRef50_Q30ZI4 Methionine synthase (B12-dependent) n=14 Tax=Desulfovibrionales RepID=Q30ZI4_DESDG Length = 841 Score = 254 bits (649), Expect = 3e-66, Method: Composition-based stats. Identities = 79/305 (25%), Positives = 116/305 (38%), Gaps = 23/305 (7%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 R L +L DGAM T L+ RG + + NP +++ VHLDY RAGA Sbjct: 35 FRRALSDDTLLFFDGAMGTMLQGRGLPAG--MSPEVFCLSNPAVLQGVHLDYARAGADVL 92 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 T ++ T G++ + + + A A T+ VAGSVGP G Sbjct: 93 TTNTFGGTRLKLPE-GMNVVEFNREMAR---------AAKAAAGQAGRTVFVAGSVGPTG 142 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 ++ + R ++ L+ G DL+ ET + +E+ A+ A Sbjct: 143 HFVKPLGD------LEFSELVDIFREQIRGLVQGGIDLVLAETHFDLAEVRAVVLAARAE 196 Query: 187 PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGL 245 S T D GT V + V + NC E + L Sbjct: 197 CNLPVGVSMTFED-GVSLTGTRPEVFVHTMQNM-GVDLIATNCSAGPEQMAGVVAGLTAA 254 Query: 246 TVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAA 305 +P++V PN+G T G + A + AG R +GGCC TTP IAA Sbjct: 255 GDIPVLVMPNAGLPELENGNTVFRLG--PEEFAAQTADFVRAGVRCLGGCCGTTPDHIAA 312 Query: 306 LKARS 310 L + Sbjct: 313 LAREA 317 >UniRef50_A9FAG8 Methionine synthase n=91 Tax=Bacteria RepID=A9FAG8_SORC5 Length = 1281 Score = 253 bits (647), Expect = 5e-66, Method: Composition-based stats. Identities = 66/349 (18%), Positives = 126/349 (36%), Gaps = 51/349 (14%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLAD-----------SLWS--AKVLVENPELI 51 +PL+ LL ++ I+++DGAM T + G AD L + + PE+I Sbjct: 11 HPLQKLL-QRRIVIIDGAMGTTIRTYGMKEADIRGQRFADSKKDLLNNGDLFSLTQPEMI 69 Query: 52 REVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQ-----------------------S 88 ++H + AGA T ++ AT + +D+ + + Sbjct: 70 CDIHRRFLEAGADIIETNTFGATSITQSEFFVDDPREHGGRKDPAFYQGIIDDPFLNDLA 129 Query: 89 KALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLA--DGSEYRGDYHCSVEAF 146 + +S R+ + N VAG++GP L+ ++ G + + Sbjct: 130 WEINEQSARQCREWADRVA--NADGRQRFVAGAIGPLTVSLSNSPDADDPGFRVVTFDQV 187 Query: 147 QAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRA-----RAWFSFTLRDSE 201 + + ++ AL+ G+D+L ET+ + +A + S + Sbjct: 188 KQAYVHQIRALIAGGSDVLLVETIFDSLNAKAALVAIREVFDKDGKTLPVMISAAVGRGG 247 Query: 202 HLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLVVYPNSGEHY 260 + + +A+G+NC + L L + + YPN+G Sbjct: 248 ETMISAQTVEAFWNAVKHVNPLAIGLNCSLGPDLMYPFLSDLSEKSSAAISCYPNAGLP- 306 Query: 261 DAVSKTWHHHGEHCAQLADYLPQWQAAG-ARLIGGCCRTTPADIAALKA 308 + +A ++ + AG + GGCC TP IAA+ Sbjct: 307 --NPLSPTGFDLEPPDMARHIGGFADAGLLNIAGGCCGNTPEHIAAIAK 353 >UniRef50_A8Q150 Probable homocysteine S-methyltransferase, putative n=1 Tax=Brugia malayi RepID=A8Q150_BRUMA Length = 315 Score = 252 bits (644), Expect = 1e-65, Method: Composition-based stats. Identities = 97/306 (31%), Positives = 151/306 (49%), Gaps = 11/306 (3%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNL-ADSLWSAKVLVENPELIREVHLDYYRAGAQC 65 + A + I +LDG TELEA G N+ +SLWS L +NP+LI +VH + AG+ Sbjct: 1 MDAHFTCEKIQILDGGFGTELEAVGYNIENNSLWSCAALFDNPDLILQVHKRFIEAGSDI 60 Query: 66 AITASYQATPAGFA-ARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP 124 +T SYQA + G+ + +++ + K V LA +A + + GSVGP Sbjct: 61 ILTNSYQACINTMMSSHGMTKNAAESSLKKLVSLAEQAINE----CSVREKVKIVGSVGP 116 Query: 125 YGAYLADGSEYRGDYHCSVEA--FQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 YG DGSEY G Y +E +H + LL AG ++A ET+P++ E A+ + Sbjct: 117 YGVIFNDGSEYNGYYVDEIEQQVLVDYHMQQTIPLLQAGLKVIAYETVPSYKEALAILKA 176 Query: 183 LTAYPRAR-AWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQH 241 A + W SF+ ++ + + V +A +P ++ +GINC + T LQ Sbjct: 177 ADAIGYSYNFWISFSCKNDKQTNHNEDFCKSVEKIAHHPSILGIGINCTSPNYITPLLQS 236 Query: 242 LH-GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 + LP +VYPNSGE Y+ +K W + + +W+ G +++GGCCR Sbjct: 237 ASTSVNSLPFIVYPNSGEVYEHSTKKWRIGKCRFPDIEQLI-EWKDLGVKVVGGCCRVGA 295 Query: 301 ADIAAL 306 I L Sbjct: 296 EKIKEL 301 >UniRef50_C4XYV2 Putative uncharacterized protein n=1 Tax=Clavispora lusitaniae ATCC 42720 RepID=C4XYV2_CLAL4 Length = 329 Score = 252 bits (644), Expect = 1e-65, Method: Composition-based stats. Identities = 110/335 (32%), Positives = 166/335 (49%), Gaps = 40/335 (11%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEAR------GCNLADSLWSAKVLVENPELIREV 54 MS L K+ +L+ DGA+ T+LEA LWS L+ +PELI + Sbjct: 1 MSFKEAL-----KKSVLVQDGALGTQLEALIPLDDPHSVKGSPLWSTNALLYSPELISSI 55 Query: 55 HLDYYRAGAQCAITASYQATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQA 113 H Y AGA ITA+YQA+P + +D AQ+K + KSVE A +A Sbjct: 56 HKQYVEAGADMIITATYQASPQTLSKYENMDLAQAKKVWTKSVECALEA-----TRTHPE 110 Query: 114 GTLLVAGSVGPYGAYLADGSEYRGDY-HCSVEAFQAFHRPRVEALLDAG-ADLLACETLP 171 + + GS+GPYGAYLA+G+EY GDY S + +HR V + D++A ET+P Sbjct: 111 KKIFIGGSIGPYGAYLANGAEYSGDYGDISSDQLMDYHRDIVRFYAETKEVDVIAFETVP 170 Query: 172 NFSEIEALAELLTAYPR----ARAWFSFTLRDSEHLSDGTPLRDVVALLAG------YPQ 221 NF+E++A+ L+ + S + +D++HL DGTPL V+ + Sbjct: 171 NFAEVQAIFSLIEQMFNANLHKEFYVSLSCKDADHLVDGTPLEQVIRYILSKKSSQISDN 230 Query: 222 VVALGINCIALENTTAALQHLHGLT------VLPLVVYPNSG-EHYDAVSKTWHHHGEHC 274 +V +G NC+ E + ++ ++ + L L+VYPN G E D + + Sbjct: 231 LVGIGCNCVPFEIVSDFIETVNRVCQNNGSEQLSLLVYPNLGFEPTDTANYAFRSST--- 287 Query: 275 AQLADYLPQWQAA-GARLIGGCCRTTPADIAALKA 308 + A + +W R+IGGCC T PA+IA +K Sbjct: 288 EKWASSVAKWALYSNVRVIGGCCSTGPAEIAQIKD 322 >UniRef50_A5ZUF2 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=A5ZUF2_9FIRM Length = 289 Score = 251 bits (641), Expect = 2e-65, Method: Composition-based stats. Identities = 63/309 (20%), Positives = 128/309 (41%), Gaps = 24/309 (7%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M+ R L ++IL+LDGA + L A G + + ++++ ++I+++ Y + Sbjct: 1 MT-KEEFRKL--TENILILDGATGSNLMASGMP--RGICTETWVIDHKDIIQDLQRAYIQ 55 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AG+Q ++ GL + + + V +++ + VAG Sbjct: 56 AGSQVIYAPTFGGNSINLEKHGL-RDKIEEINRTLVGYSKELA---------GSGIYVAG 105 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 + G+++ +Y + ++ ++ L DAG DL+A ET+ N E A Sbjct: 106 DITTSGSFITADGDY------TYTEAYNMYQEQIRILADAGIDLIAAETMINIEETLAAV 159 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAAL 239 + + + T+ + G + L A+GINC + + + + Sbjct: 160 DAAASVCDLPIMCTMTVEADGSIFSGGNAVEAAVSLEA-AGADAVGINCSVGPDQLVSVV 218 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 +++ +P++ PN+G K + + + A ++ GA ++GGCC TT Sbjct: 219 RNIKENVSIPVIAKPNAGMPV-IDEKGNAVYSMNAEEFAHHMKVLIENGASVVGGCCGTT 277 Query: 300 PADIAALKA 308 P+ I AL Sbjct: 278 PSFIKALHD 286 >UniRef50_C7N1R7 Methionine synthase (B12-dependent) n=5 Tax=Bacteria RepID=C7N1R7_SLAHD Length = 820 Score = 251 bits (641), Expect = 3e-65, Method: Composition-based stats. Identities = 70/309 (22%), Positives = 113/309 (36%), Gaps = 27/309 (8%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRA 61 +++ L A+L + L+ DGAM T L+A G + + + +P + +H Y A Sbjct: 19 TKDEYLAAVLRGEAYLVFDGAMGTMLQASGMEAGE--LPELLCLTDPAGVTAIHRQYVEA 76 Query: 62 GAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGS 121 G+Q T ++ A A + + +V AR+ +G VAG Sbjct: 77 GSQAITTNTFGANARKLGDA----ATVEDVFAAAVACARE-----------SGARYVAGD 121 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 +GP G L S + V A AGADLL ET+ + E++A Sbjct: 122 IGPTGGLLEPLGT------MSFDEAYDLFAQEVRAADAAGADLLVIETMADLLEMKAAVL 175 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQ 240 + + T + GT + L V LG+NC + + Sbjct: 176 AAKENSDLPIFATMTFGEDGRTFLGTSPQIAALTLDAL-GVNVLGVNCSLGPSDLQPIVS 234 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 + P++ N+G T + + A+ + G +IGGCC T P Sbjct: 235 AMLETATCPVMAQANAGLPSVVDGHTV--YSIMPDEYANAVQAMVDEGVSVIGGCCGTNP 292 Query: 301 ADIAALKAR 309 I L A Sbjct: 293 DYIRQLAAM 301 >UniRef50_Q024B4 Homocysteine S-methyltransferase n=2 Tax=Bacteria RepID=Q024B4_SOLUE Length = 304 Score = 250 bits (640), Expect = 4e-65, Method: Composition-based stats. Identities = 70/315 (22%), Positives = 121/315 (38%), Gaps = 29/315 (9%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 N PL+ ++ ++ LL DGAM T+L G + + +PE + + Y AG Sbjct: 1 MNEPLQDVI-RRRPLLGDGAMGTQLMFAGLEQGN--CGELWNLTHPERVLGIQRRYAEAG 57 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 + C +T ++ + G + + +VE+AR+A V G + Sbjct: 58 SDCILTNTFGGSRIMLNRHG-SSGKVVEINRAAVEIAREA--------FGGRAGYVIGDI 108 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP+G + ++ + E ++ + AL+DAGAD + ET + E++ E Sbjct: 109 GPFGGLMQPYGDF------TEEDVRSAFGEQAGALVDAGADAIIIETQTSLEELQLGIEA 162 Query: 183 LTAYPRARAWFSFTLR-----DSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENT-- 235 S + G + + + +NC + Sbjct: 163 AREAGAPCVIGSMAYDVTLDGSTFRTMMGVDPERAAGFMQEH-DADIVALNCGTGMDMAR 221 Query: 236 -TAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGG 294 A+ T LP++V PN+G K + E Q+A + AGA +IG Sbjct: 222 AREAVLRYRKATDLPVMVQPNAGVPKLISMKVV--YDETPEQMASGVAPLLCAGANIIGA 279 Query: 295 CCRTTPADIAALKAR 309 CC +TP I A +A Sbjct: 280 CCGSTPEHIRAFRAE 294 >UniRef50_Q1NSQ8 Methylenetetrahydrofolate reductase n=3 Tax=Deltaproteobacteria RepID=Q1NSQ8_9DELT Length = 704 Score = 250 bits (638), Expect = 5e-65, Method: Composition-based stats. Identities = 72/310 (23%), Positives = 122/310 (39%), Gaps = 24/310 (7%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 L ++ ++L DGA+ T L ++G L + ++ + +P+LI +H +Y RAG Sbjct: 76 MKPDFLEYL-QEKVILGDGAIGTYLYSKGIELGKD--TDRLNLSDPDLIYSLHEEYIRAG 132 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 +Q T ++ A A GL E Q++ + +A++A + VAGSV Sbjct: 133 SQLIETNTFGANRLKLLANGL-ENQAREINLAGAGIAKRAA---------GEDIYVAGSV 182 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G A + ++ ALL+A DLL ET + E+ E Sbjct: 183 GPTGVEFP-----LEAGEIEPAEVAAAYEEQISALLEAEVDLLILETFTHLDELLIALET 237 Query: 183 LTAY-PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQ 240 P+ + G +G NC + + A++ Sbjct: 238 ARRLAPQHPIVAQMAYPAQGRTARGDHALTCGTAAIA-AGASLVGANCGRGVNSMLTAIE 296 Query: 241 HLHGLTV-LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 L L +PL +PN+G + + +A + + GARL+GGCC T+ Sbjct: 297 ALSPLRDQVPLSAFPNAGFPEIVGHR--MIYPAQPEYMARVVGEMIKLGARLVGGCCGTS 354 Query: 300 PADIAALKAR 309 P I + + Sbjct: 355 PTHIQEFRKQ 364 >UniRef50_Q8DUN2 Methylenetetrahydrofolate reductase n=12 Tax=Streptococcus RepID=Q8DUN2_STRMU Length = 618 Score = 249 bits (637), Expect = 7e-65, Method: Composition-based stats. Identities = 78/308 (25%), Positives = 119/308 (38%), Gaps = 29/308 (9%) Query: 7 LRALLDK--QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 + LLDK DIL+ DGAM T L A G + +PE I +H Y AGA Sbjct: 1 MSRLLDKLKTDILVADGAMGTLLYADGLES----CHEYYNISHPERILAIHQAYIAAGAD 56 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP 124 T +Y A + G + + KA+ +V LAR+A V G++G Sbjct: 57 IIQTNTYGAKRHRLKSFG-HDKEVKAINQAAVHLARQAA---------GDNTFVLGTIG- 105 Query: 125 YGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAG-ADLLACETLPNFSEIEALAELL 183 S S+E + + LL+ D L ET + E+EA + L Sbjct: 106 -------ASHGLKHCELSLEDIISQTVEQARFLLETKQIDGLLLETYYDIEELEAALKAL 158 Query: 184 TAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHL 242 + L + +G PL + + L +G+NC + + + + + Sbjct: 159 RPLTDLPIITNVALHEPGITENGRPLVEAFSNLV-MLGADIVGLNCHLGPYHMIQSFKQV 217 Query: 243 HGLTVLPLVVYPNSGEHYD--AVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 L YPN+ ++T +H ++ + G RLIGGCC TTP Sbjct: 218 PLFAQSYLSAYPNASLLSFSSDDNETPYHFSQNADYFEYCAKLFVEEGVRLIGGCCGTTP 277 Query: 301 ADIAALKA 308 I A+K Sbjct: 278 EHIKAIKR 285 >UniRef50_C5MAR2 Putative uncharacterized protein n=1 Tax=Candida tropicalis MYA-3404 RepID=C5MAR2_CANTT Length = 312 Score = 249 bits (636), Expect = 9e-65, Method: Composition-based stats. Identities = 92/314 (29%), Positives = 159/314 (50%), Gaps = 21/314 (6%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADS------LWSAKVLVENPELIREVHLDYYR 60 + + ++ L++DGA+ TELE + + S LWS + L+ NPEL+ +VHLDY Sbjct: 4 FKEIFQQKK-LVIDGALGTELERLLPSSSASLPSNSPLWSGQALINNPELVEQVHLDYIN 62 Query: 61 AGAQCAITASYQATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVA 119 AGA IT++YQ + A G D +S L ++ A+ A +++A Sbjct: 63 AGADIIITSTYQTSYASLNKYAGYDMKKSVELWNSALGAAKNAVNR-----SGRSDVIIA 117 Query: 120 GSVGPYGAYLADGSEYRGDY-HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 GS+GPY LA+GSEY GDY + + +H P E ++ D++ ET+PNF+E++ Sbjct: 118 GSIGPYATVLANGSEYSGDYQGATYDDLVEYHTPLFEFYDNSDVDVICIETIPNFTELKV 177 Query: 179 LAELLTAYPRARAWFSFTLRDSEHLSDGTPL---RDVVALLAGYPQVVALGINCIALENT 235 + +++ Y + + + + + LSDGT L +V + + + +GINC + Sbjct: 178 VIDMMKKYTKKEYFIAVNPQTANALSDGTTLDKVAEVFKTIEDTSRFLGVGINCTNYDLV 237 Query: 236 TAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAA-GARLIGG 294 L++ T P+++YPN G YD + + H + + +W + R +GG Sbjct: 238 NDILKYF---TDFPVLIYPNMGFVYDTETHKFVPEANHELSWENAVKKWLNSDNVRAVGG 294 Query: 295 CCRTTPADIAALKA 308 CC T P++I+ + Sbjct: 295 CCSTGPSEISIVAK 308 >UniRef50_B2A781 Homocysteine S-methyltransferase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A781_NATTJ Length = 793 Score = 248 bits (634), Expect = 2e-64, Method: Composition-based stats. Identities = 66/306 (21%), Positives = 126/306 (41%), Gaps = 27/306 (8%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M + L + +L LDG+ TEL+ RG + + +++ +L++ VH DY Sbjct: 1 MKLKDQLVNK-TLEKLLFLDGSYGTELQRRGFEGN----AEILNLQDQDLVKNVHYDYAS 55 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGA +T ++ G E + + + VELA+++ E +LV G Sbjct: 56 AGADLILTNTFGGNRLKLKDAGY-EDKVAEINSRGVELAKESAENI------DRDVLVVG 108 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 + G ++ + S Q + + L+++G DL+ ET+ + E++A Sbjct: 109 DISSTGRFIEPVGD------LSFTKAQQVFQEQGRYLIESGVDLIKIETMTDIKELKAAI 162 Query: 181 ELLTAY-PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAA 238 + + S + GT + V L+ P V +G+NC + ++ Sbjct: 163 LGIRSIDEDLPLIVSMSFEQDGKTITGTSVPSYVTLMNDLP-VDIIGLNCGVKSKDMLDL 221 Query: 239 LQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG-ARLIGGCCR 297 ++ ++ PL + PN+G+ + E + + YL ++GGCC Sbjct: 222 VKQASYYSLKPLSISPNAGDP-----DLDLSYSEDPQEFSFYLDAISDLDMVAIVGGCCG 276 Query: 298 TTPADI 303 TTP + Sbjct: 277 TTPEYV 282 >UniRef50_UPI000180BE5F PREDICTED: similar to CG10623 CG10623-PA n=1 Tax=Ciona intestinalis RepID=UPI000180BE5F Length = 305 Score = 248 bits (633), Expect = 2e-64, Method: Composition-based stats. Identities = 104/305 (34%), Positives = 155/305 (50%), Gaps = 23/305 (7%) Query: 14 QDILLLDGAMATELEARGCNL-----ADSLWSAKVLVENPELIREVHLDYYRAGAQCAIT 68 +DI +LDG + T+L G + D LWSA+VL E PE I + HL + +AG+ T Sbjct: 2 EDIKILDGGLCTDLFINGGFVRAEVNKDPLWSARVLYEKPEEIMKAHLRFIKAGSDVVST 61 Query: 69 ASYQATPAGFAARG-LDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGA 127 SYQA+ G+ + + +++ +IG SV++A++A + +LVAGS+ PYGA Sbjct: 62 CSYQASVQGYMEHAQVTKEKAEKIIGSSVDVAKQAVQE------SGRRVLVAGSISPYGA 115 Query: 128 YLADGSEYRGDY--HCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA 185 L D SEY G Y S + FH+ + L G DL A ETLP+ E LAE+L Sbjct: 116 ILHDMSEYTGSYIDTTSEQQLSDFHKTNIRILASKGVDLFAFETLPSLKEALVLAEILRE 175 Query: 186 YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL 245 YP +AW SF+ ++ H G P +V L Y Q++A+G+NC E ++ +Q HG Sbjct: 176 YPTLKAWVSFSNKNGTHTCYGEPFEEVFKALGNYHQIIAIGLNCCKSETISSFIQLAHGN 235 Query: 246 TVLP--LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGAR-LIGGCCRTTPAD 302 L++YPN+ + E + + W + IGGCC T+P Sbjct: 236 LAKHQRLIIYPNNCAGGNVN------SSEAPLEWLPKVKTWLESNLIGWIGGCCMTSPFQ 289 Query: 303 IAALK 307 I +K Sbjct: 290 IGQIK 294 >UniRef50_B9DIA5 Methylenetetrahydrofolate reductase n=10 Tax=Staphylococcus RepID=B9DIA5_STACT Length = 613 Score = 247 bits (632), Expect = 2e-64, Method: Composition-based stats. Identities = 67/298 (22%), Positives = 117/298 (39%), Gaps = 28/298 (9%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K+++L+ DGA+ T L + G + + +P+ I ++H Y +AGA T +Y Sbjct: 9 KENVLVADGAIGTILYSEGIDT----CPEAYNITHPKKIEQIHRSYIQAGADVIQTNTYG 64 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY-GAYLAD 131 A GL E Q K + +V +A+KA + G+VG + G + Sbjct: 65 ANFEKLQTFGL-EHQVKDITRAAVRIAKKAANE---------DTFILGTVGGFKGVKQNE 114 Query: 132 GSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARA 191 S YH + +++ L+D G D L ET + +E+ + Sbjct: 115 LSLSTILYHTDI---------QIDTLIDEGVDALLFETYYDLNELLQVIRATKKKYDIPV 165 Query: 192 WFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPL 250 T ++ +L DGT + + + + +G+NC + + H+ L Sbjct: 166 IAQLTASNTNYLQDGTEINEALKQVEA-EGADVIGLNCHHGPHHMQQSFTHIELPQHALL 224 Query: 251 VVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 YPN+ + + ++ + G LIGGCC TTP I +K Sbjct: 225 SCYPNASLLDFE--NSSIKYSDNASYFGKIAKSLVKEGVHLIGGCCGTTPEHIHYIKE 280 >UniRef50_C0D4W7 Putative uncharacterized protein n=3 Tax=Clostridium RepID=C0D4W7_9CLOT Length = 836 Score = 247 bits (632), Expect = 3e-64, Method: Composition-based stats. Identities = 74/312 (23%), Positives = 118/312 (37%), Gaps = 38/312 (12%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 +Q L DG + L+A+G + + PE+ ++H DY AGA T ++ Sbjct: 8 RQRRLFFDGGTGSLLQAQGLKAGE--LPEVWSITRPEVCVKLHRDYLEAGADIIKTNTFG 65 Query: 73 ATPAGFA-----------ARGLDEAQ-------SKALIGKSVELARKAREAYLAENPQAG 114 A F GL A ++ +++ AR+A AG Sbjct: 66 ANGLKFKGRENASGAQGPEAGLPAADRPADSYSVDEIVTAAMKNARRAVAE-------AG 118 Query: 115 TLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFS 174 +A +GP G L + EA ++ V GADL+ ET+ + Sbjct: 119 HGYIALDLGPTGKLLKPLGD------LDFEAAVELYKEVVRIGRREGADLVLIETMSDSY 172 Query: 175 EIEALAELLTAYP-RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IAL 232 E++A + + L G + VALL G +V ALGINC + Sbjct: 173 ELKAAVLAAKEAGEGLPVFATVVFDGKGKLLTGGNVESTVALLEGL-RVDALGINCGLGP 231 Query: 233 ENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLI 292 ++ L ++ LP++V PN+G + + A + + GA + Sbjct: 232 VQMKGIVEELLKVSSLPVIVNPNAGLPRSENG--VTLYDIDGDRFAQVMEEIARMGACFL 289 Query: 293 GGCCRTTPADIA 304 GGCC TTP I Sbjct: 290 GGCCGTTPEHIQ 301 >UniRef50_C6LEJ3 Vitamin B12-dependent methionine synthase family protein n=3 Tax=Clostridiales RepID=C6LEJ3_9FIRM Length = 291 Score = 247 bits (632), Expect = 3e-64, Method: Composition-based stats. Identities = 71/310 (22%), Positives = 127/310 (40%), Gaps = 24/310 (7%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M++ R L +DI++LDGA + L G + + + ++EN + + E+ Y Sbjct: 1 MTKKE-FRKL--AEDIIILDGATGSNLMKAGMP--RGICTEQWILENEQTLIELQRAYVE 55 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AG+Q ++ A AA GL + + + V+++ +A G VAG Sbjct: 56 AGSQIVCAPTFGANCRNLAAHGL-RDKLADMNKRLVDISLRA---------TEGRAYVAG 105 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 + G + + + E + ++ L++AGADLL ET+ + E A Sbjct: 106 DMSTGGVAIGSSPD------ATYEEAFERYAEQITHLVNAGADLLLAETMISIDETVAAV 159 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAAL 239 E S T+ L G + + L A+GINC + + A + Sbjct: 160 EAAKEICDLPILCSMTVEADGSLYFGGSALEALETLQEV-GASAVGINCSVGPDQLEAVI 218 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 + + +P++ PN+G K + ++ + AGA ++GGCC TT Sbjct: 219 AEMKKIARVPVIAKPNAGMPKITE-KGEALYSMTPEDFGKHMERLVEAGAGIVGGCCGTT 277 Query: 300 PADIAALKAR 309 P I + +R Sbjct: 278 PEYIREMCSR 287 >UniRef50_D0NSW2 Homocysteine S-methyltransferase, putative n=1 Tax=Phytophthora infestans T30-4 RepID=D0NSW2_PHYIN Length = 332 Score = 247 bits (632), Expect = 3e-64, Method: Composition-based stats. Identities = 116/318 (36%), Positives = 165/318 (51%), Gaps = 18/318 (5%) Query: 7 LRALL-DKQDILLLDGAMATELEA------RGCNLADSLWSAKVLVENPELIREVHLDYY 59 L+ LL DK +++LDG ATELE +L +++ H +Y+ Sbjct: 9 LQQLLADKSRVVVLDGGFATELEKDPRVDLSASSLWSGSLLLDQNQHLQDVVVNAHTNYF 68 Query: 60 RAGAQCAITASYQATPAGFAARGLDE-AQSKALIGKSVELARKAREAYLAENPQAGTL-- 116 AGA A T SYQA+ GF G+ + L KS++L +AR+A E Q+ + Sbjct: 69 LAGADVATTVSYQASVDGFKREGVTALEDVEKLFAKSIDLGAQARDAAWNELQQSKRIKP 128 Query: 117 LVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLD-AGADLLACETLPNFSE 175 LV S+G YGA LADGSEYRGDY + A+H+ R A A+ L CET+P E Sbjct: 129 LVGASIGCYGAALADGSEYRGDYGKTKNELVAWHKHRFAFFTSYAPANFLICETIPCLVE 188 Query: 176 IEALAELLTAYPRARAWFSFTLRDSEHLSDGTPLR---DVVALLAGYPQVVALGINCIAL 232 +EA +LL +P A A + + + L+ G P+ +++A L Q++A+GINC Sbjct: 189 VEAFVDLLNEFPTAHAIVAVACHNGKELNSGEPIARIPEILAKLNNPSQLLAIGINCTPP 248 Query: 233 ENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEH--CAQLADYLPQWQAAGAR 290 + + L L P VYPNSGE +D V+K W + +YLP+W AGAR Sbjct: 249 QYVESLLLEL--DCPWPKAVYPNSGEGWDGVNKKWLPADNTGGPSSWEEYLPKWYDAGAR 306 Query: 291 LIGGCCRTTPADIAALKA 308 GGCCRT+P DI A++ Sbjct: 307 FFGGCCRTSPDDIRAIRE 324 >UniRef50_Q6BZK6 DEHA2A00616p n=1 Tax=Debaryomyces hansenii RepID=Q6BZK6_DEBHA Length = 351 Score = 247 bits (631), Expect = 3e-64, Method: Composition-based stats. Identities = 102/343 (29%), Positives = 162/343 (47%), Gaps = 38/343 (11%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNL---------ADSLWSAKVLVENPELIRE 53 N + L++ + L++DGA+ T+LE + L LWSA VL++NPELI+E Sbjct: 1 MINDINTLINTK-PLVIDGALGTQLETKFSKLLQQDNINIQTHPLWSALVLLKNPELIQE 59 Query: 54 VHLDYYRAGAQCAITASYQATPAGFAAR--GLD-EAQSKALIGKSVELARKAREAYLAEN 110 VH DY +GA T++YQA+ G G++ + + A+ K++ELA AR YL Sbjct: 60 VHYDYMCSGANIITTSTYQASKRGLLEYAPGIENDDEVNAVYDKAIELAVDARSQYLENM 119 Query: 111 PQA------GTLLVAGSVGPYGAYLADGSEYRGDYH---CSVEAFQAFHRPRVEALL-DA 160 + + + GS+GP+GAYLA+G+EY G Y + + FH + + Sbjct: 120 GKGMNTLTNKEIFICGSIGPFGAYLANGAEYTGKYGSHITEPQELKKFHYDITSQFISNP 179 Query: 161 GADLLACETLPNFSEIEALAELLTAY---PRARAWFSFTLRDSEHLSDGTPLRDVVALLA 217 D++ ET+PN+SE + + L+ + S +D + + DGTP+ VV L Sbjct: 180 KCDIIGFETIPNYSEFQQIVHLMEELLQKTNKPFYISLNFKDPKTICDGTPITQVVDYLN 239 Query: 218 G--------YPQVVALGINCIALENTTAAL---QHLHGLTVLPLVVYPNSGEHYDAVSKT 266 + LG NC+ LE T L L+ + PL+ YPN+G +YD Sbjct: 240 ERLSNNEKLRSAFIGLGCNCVPLEIATNILLNMSDLNNVHRFPLIAYPNAGLNYDLSKGE 299 Query: 267 WHHHGEHCAQLADYLPQWQA-AGARLIGGCCRTTPADIAALKA 308 + D +W RL+G CC + P +I ++ Sbjct: 300 YSIKSSEKQVWEDSCREWLEKLNVRLVGACCGSGPDEILTIRE 342 >UniRef50_D1B7X8 Homocysteine S-methyltransferase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B7X8_THEAS Length = 816 Score = 246 bits (628), Expect = 7e-64, Method: Composition-based stats. Identities = 86/308 (27%), Positives = 127/308 (41%), Gaps = 30/308 (9%) Query: 4 NNPLRALLDK-QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 +R+LL + + L++DG M T+L RG + ++ + P+ +REVH Y +G Sbjct: 5 RGRVRSLLGEVRSPLVMDGGMGTQLAERG--WHPPMLPEEMCLHMPQAVREVHESYVESG 62 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 A T S+ + + RGL ++ L +S ++AR+A G LVAGSV Sbjct: 63 AAVLETNSFGGSVRKLSMRGLG-HLAEELALRSAQIARQAA----------GDALVAGSV 111 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G LA E S E P+V L+ GADL+ ET+ + E A E Sbjct: 112 GPTGEMLAPLGE------MSFEEAVKSFEPQVRGLIRGGADLILIETMLDLKEAAAAVEA 165 Query: 183 LTAYPRA-RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQ 240 + SFT GT + +G NC + ++ Sbjct: 166 VKRVDPLFPFVVSFTFDRDGRTVTGTTPEAAACWAQAV-GALGVGANCGLGPRGYVPVVR 224 Query: 241 HLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 L + LP+ VYPN+G + + AGA +IGGCC TTP Sbjct: 225 RLAEASPLPVWVYPNAGVPSAGD-------YLGPDEFVGECEELLKAGASVIGGCCGTTP 277 Query: 301 ADIAALKA 308 + AL A Sbjct: 278 DHVRALAA 285 >UniRef50_C6VPC5 Methylenetetrahydrofolate reductase n=3 Tax=Lactobacillus plantarum RepID=C6VPC5_LACPJ Length = 618 Score = 245 bits (625), Expect = 2e-63, Method: Composition-based stats. Identities = 71/308 (23%), Positives = 118/308 (38%), Gaps = 26/308 (8%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELE-ARGCNLADSLWSAKVLVENPELIREVHLDYY 59 M L +Q +L+ DGAM T L G N A + + +P+ I VH Y Sbjct: 1 MKFKQAL-----QQRVLVADGAMGTLLYGNYGINSAF----ENLNLTHPDTILRVHRSYI 51 Query: 60 RAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVA 119 RAGA T +Y A L + Q + +V++A ARE + + Sbjct: 52 RAGADIIQTNTYAANRLKLTRYDLQD-QVTTINQAAVKIAATAREH------ADHPVYIL 104 Query: 120 GSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAG-ADLLACETLPNFSEIEA 178 G++G G + A ++ ALL D + ET + E+ A Sbjct: 105 GTIGGLA-----GDTDATVQRATPATIAASVTEQLTALLATNQLDGILLETYYDLPELLA 159 Query: 179 LAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTA 237 +++ A+ + ++ L +GT D + L +G NC + Sbjct: 160 ALKIVKAHTDLPVITNVSMLAPGVLRNGTSFTDAIVQLNA-AGADVIGTNCRLGPYYLAQ 218 Query: 238 ALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCR 297 + ++L + L VYPN+G + + +Y +++ G +IGGCC Sbjct: 219 SFENLAIPANVKLAVYPNAGLPGTDQDGAV-VYDGEPSYFEEYAERFRQLGLNIIGGCCG 277 Query: 298 TTPADIAA 305 TTP +A Sbjct: 278 TTPLHTSA 285 >UniRef50_D2PQB9 Methionine synthase n=2 Tax=Actinomycetales RepID=D2PQB9_9ACTO Length = 1199 Score = 244 bits (624), Expect = 3e-63, Method: Composition-based stats. Identities = 85/325 (26%), Positives = 132/325 (40%), Gaps = 34/325 (10%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLAD-------------SLWSAKVLVEN 47 M+ + LR LLD+ I +LDGA T L+A D S + + Sbjct: 1 MT-TSSLRDLLDR-RIAVLDGAWGTMLQAANLTSEDYQGDRFLDHSHDVSGDPDLLNLMR 58 Query: 48 PELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYL 107 P+LI +VH Y AGA T ++ AT G A GL + + + + LAR+A + Sbjct: 59 PDLILDVHRQYLDAGADITTTNTFTATSIGQADYGLQ-SLVREMNLEGARLARQAADEAG 117 Query: 108 AENPQAGTLLVAGSVGPYGAYLA--DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLL 165 VAGSVGP L+ E S E + + ++ AL D G DLL Sbjct: 118 G-------RFVAGSVGPLNVTLSLSPRVEDPAYRAVSFEQVRDSYAEQITALRDGGVDLL 170 Query: 166 ACETLPNFSEIE-ALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVA 224 ET+ + + A+A A P W S + S G + + + + + Sbjct: 171 LIETIFDTLNCKAAIAAAREAAPELPLWISLFVDLSGRTLSGQTV-EAWWNSIEHAEPLV 229 Query: 225 LGINCI-ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQ 283 +G+NC + L + +PN+G + + E Q A + + Sbjct: 230 VGVNCSLGARELRPHVADLARFADTYVASHPNAGLP-----NAFGGYDETPEQTAGMIGE 284 Query: 284 WQAAG-ARLIGGCCRTTPADIAALK 307 + +G ++GGCC TTPA IA + Sbjct: 285 FAESGLVNIVGGCCGTTPAHIAKIA 309 >UniRef50_A8SPV0 Methylenetetrahydrofolate reductase n=2 Tax=Clostridiales RepID=A8SPV0_9FIRM Length = 606 Score = 244 bits (622), Expect = 5e-63, Method: Composition-based stats. Identities = 74/309 (23%), Positives = 125/309 (40%), Gaps = 22/309 (7%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M+ LR L L+ DGA T + + +PE + E+H +Y + Sbjct: 1 MNILESLRDKL-----LVADGAFGTCYAGMYGERGT-VAPELANMRHPERVLEIHKEYVK 54 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGA T ++ A A A D + + +V+LA++A A VAG Sbjct: 55 AGAGIIRTNTFAANTASLDA---DMDYVISNVRAAVKLAKQAVAETGAPGIDRKKAYVAG 111 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 +GP D ++ + ++ EA+ D G D++ ET P F+ +E + Sbjct: 112 DIGPI----------PADAGLTLNERVSQYKLLGEAMQDMGVDIIWFETFPEFNVLEPVV 161 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAAL 239 + L A SF + + + G R +++ A V +G+NC + + L Sbjct: 162 KQLKARKDTPVMVSFCVNQFGYSNCGFSARALLSQAAANSDVDCVGLNCGVGPYHMLQLL 221 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 + L P+ + PN+G S+ + ++ D + A GA +IGGCC T Sbjct: 222 KKLDIDCGKPVSIMPNAGYPKFTQSRLVFN--DNKEGFIDKIQDIAALGADIIGGCCGTN 279 Query: 300 PADIAALKA 308 P I +K Sbjct: 280 PEYIRQIKE 288 >UniRef50_B1H0N5 Homocysteine S-methyltransferase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=B1H0N5_UNCTG Length = 801 Score = 243 bits (621), Expect = 5e-63, Method: Composition-based stats. Identities = 66/305 (21%), Positives = 113/305 (37%), Gaps = 23/305 (7%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 +L K IL++DGA TEL+ + L ++ ++ PE I +++ Y AG Sbjct: 2 NKQKFLDIL-KSRILIMDGATGTELQKKKY-LDGVEIPEEINIKFPERIADIYSSYINAG 59 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 + + ++ A GL ++ +I ++L R+ + +VAG + Sbjct: 60 SDIILANTFGANLIRLKQHGL-LDKADDIIKSGIDLIRE----------ISSDTIVAGDI 108 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 G Y+ + + +V L GAD++ ET+ E +A Sbjct: 109 SSIGEYIEPLGS------LTFDEAYNSFAFQVSLLQKHGADVIVIETMTEIKETKAAILA 162 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQH 241 T GT L+ +A+ V ALG+NC + + Sbjct: 163 AKENFDGAIIVQMTFSKDGVTVTGTDLKSFIAMAESL-GVDALGLNCSIGSRDLAELAKV 221 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 L T LP+ PN+G +T E + + + + G + GGCC T P Sbjct: 222 LCVNTNLPISFKPNAGIPVLINRETC--FPETKEEFIEASLKAYSYGVNMFGGCCGTNPE 279 Query: 302 DIAAL 306 I L Sbjct: 280 FIKIL 284 >UniRef50_C7LX76 Methylenetetrahydrofolate reductase n=1 Tax=Desulfomicrobium baculatum DSM 4028 RepID=C7LX76_DESBD Length = 599 Score = 242 bits (619), Expect = 1e-62, Method: Composition-based stats. Identities = 71/305 (23%), Positives = 114/305 (37%), Gaps = 26/305 (8%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 + +L + +++ DGAM + L RG + + + + P L++ +H Y AG Sbjct: 1 MKKHIMTVL-GERVVVADGAMGSLLFDRGVDSSS--CYDALNLTEPALVQSIHKAYADAG 57 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 A+ T ++ A L ++ + + ELAR VAG++ Sbjct: 58 AEILETNTFGANRVKLGRYDLAHT-TREINLRGAELAR---------GEAGAGRWVAGAM 107 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G G S E + + AL++ G D + ET + S + Sbjct: 108 GPLGRM--------GLDAVSQEEMEDVFSQQALALVEGGVDFIMLETFASLSLLLTALRG 159 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 + A G R+ L +G+NC I +N +Q Sbjct: 160 VKACVSVPVAAQMVFTQRGRTHSGHTARECFDALI-RAGADVVGLNCGIGPKNALEVVQG 218 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 L +T +PL V PN+G + + + A GARL+GGCC T P Sbjct: 219 LGPVT-VPLSVLPNAGFPESSGDRLI--YASSPEYFARRTAACATYGARLLGGCCGTAPE 275 Query: 302 DIAAL 306 IAAL Sbjct: 276 HIAAL 280 >UniRef50_A3TGH3 Homocysteine methyltransferase n=1 Tax=Janibacter sp. HTCC2649 RepID=A3TGH3_9MICO Length = 305 Score = 242 bits (618), Expect = 1e-62, Method: Composition-based stats. Identities = 120/303 (39%), Positives = 165/303 (54%), Gaps = 18/303 (5%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 + ALL + +LDG +T LEARG +L+ LWSA++L + P + H + AGA+ Sbjct: 14 IDALLHTGPV-VLDGGFSTALEARGHDLSGRLWSARLLRQAPSEVVAAHRTFVDAGAEIV 72 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 I+ASYQA+ AG+ A GL E + A + S+ELAR+ + G LVA SVGPYG Sbjct: 73 ISASYQASHAGYVAAGLTEEECDADLDASIELARQGAD---------GRALVAASVGPYG 123 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA- 185 A+LADGSEY G S + FH R+E L+ AG DL+A ET+P +E E + ELLT Sbjct: 124 AHLADGSEYTGYPAVSRATLREFHSRRLERLIAAGPDLVAVETIPEVAEAEVVVELLTEI 183 Query: 186 YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL 245 P W SF+ L+ G P + + ++ G +A+G+NC A + L+ G Sbjct: 184 APDLPYWVSFSATGGGRLTGGAPFAEAIGVVRG--AAIAVGVNCTAPRHIDELLE--AGG 239 Query: 246 TVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLAD-YLPQWQAAGARLIGGCCRTTPADIA 304 +P V+YPN+G YD SKTW G A A + +W GAR IGGCC I Sbjct: 240 PNVPYVIYPNAGATYDPGSKTWTEDGS--AHFAPTTVQRWNDLGARFIGGCCGIGADGIR 297 Query: 305 ALK 307 + Sbjct: 298 EIA 300 >UniRef50_C3YH00 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae RepID=C3YH00_BRAFL Length = 1318 Score = 242 bits (617), Expect = 1e-62, Method: Composition-based stats. Identities = 69/319 (21%), Positives = 116/319 (36%), Gaps = 63/319 (19%) Query: 13 KQDILLLDGAMATELE--------ARGCNLADSLW-------SAKVLVENPELIREVHLD 57 ++ I++LDG M T ++ RG D W + + + P ++ ++H Sbjct: 29 RERIMILDGGMGTMIQGYHLEEDGYRGDEFKD--WHKLLKGNNDLLSLTQPNIVYDIHKA 86 Query: 58 YYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLL 117 Y AGA A T ++ T A G+ E L S ELA+KA + A+ Sbjct: 87 YLEAGADFAETNTFSGTRIAQADYGM-EELVYRLNKVSAELAKKAADKVTADTA------ 139 Query: 118 VAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE 177 + + + LLD G D+L ET+ + + + Sbjct: 140 -------------------------WDELVDAYAEQARGLLDGGCDVLMVETIFDTANSK 174 Query: 178 ALAELL-----TAYPRARAWFSFT-LRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI- 230 A L Y + S T + S G + + + + LG+NC Sbjct: 175 AALFALSQLFEEEYKPVPIFVSGTIVDRSGRTLSGQT-SEAFVISVSQAEPMCLGLNCAL 233 Query: 231 ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG-A 289 ++ + T ++ YPN+G + E +A++L + G Sbjct: 234 GATEMRPFIEAIGKNTTSYVLCYPNAGLP-----NALGGYDETPEIMAEHLRVFAKDGLL 288 Query: 290 RLIGGCCRTTPADIAALKA 308 L+GGCC TTPA I A+ Sbjct: 289 NLVGGCCGTTPAHIKAIAE 307 >UniRef50_A6DGP4 5-methyltetrahydrofolate--homocysteine methyltransferase n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DGP4_9BACT Length = 1204 Score = 241 bits (616), Expect = 2e-62, Method: Composition-based stats. Identities = 71/331 (21%), Positives = 131/331 (39%), Gaps = 42/331 (12%) Query: 13 KQDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIRE-VHLDYYRAGAQC 65 K+ IL+LDGAM + ++ + ++ S ++ P+ +R+ +HL+Y +AGA Sbjct: 8 KEQILVLDGAMGSMVQLLKLPDSAYGGEEYAMLSDLLVFSRPDQVRDNIHLEYLKAGANI 67 Query: 66 AITASYQATPAGFAARGLDEAQSKAL---------------------IGKSVELARKARE 104 T ++ A+P + + +ELA+ A E Sbjct: 68 LETNTFGASPLRLQEFDFSKMDLSDFADLPEGLDFLENDYYALTHYFNIRGIELAQDAIE 127 Query: 105 AYLA-ENPQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGAD 163 Y + L VAGS+GP ++ + + +V+A++ A D Sbjct: 128 KYKKMDEYDGRPLFVAGSIGPSNWVISSTAANLNK--TDFATIKQNFYLQVKAMMQANVD 185 Query: 164 LLACETLPNFSEIEA----LAELLTAYP-RARAWFSFTLRDSEHL-SDGTPLRDVVALLA 217 +L ET + E++A + + T+ + T + A + Sbjct: 186 VLLFETQQDMLELKASIAGAHQAAEELGFKVPIMAQVTVDQFNKMQIFNTDMEAAYAAVG 245 Query: 218 GYPQVVALGINCI-ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQ 276 G + GINC E + L ++ LP+ V PN+G+ +T + + Sbjct: 246 GI-GIDVFGINCTLGPELMQKVIPALAQMSELPISVVPNAGQPISVNGETV--YPLAPEK 302 Query: 277 LADYLPQW-QAAGARLIGGCCRTTPADIAAL 306 + +Y+ + G ++GGCC TTPA IA + Sbjct: 303 MGEYMRDYEAENGINIVGGCCGTTPAHIAEI 333 >UniRef50_A5DCB0 Putative uncharacterized protein n=2 Tax=Pichia guilliermondii RepID=A5DCB0_PICGU Length = 313 Score = 241 bits (615), Expect = 3e-62, Method: Composition-based stats. Identities = 89/316 (28%), Positives = 152/316 (48%), Gaps = 36/316 (11%) Query: 14 QDILLLDGAMATELEARGCN-----LADSLWSAKVLVENPELIREVHLDYYRAGAQCAIT 68 L+LDG + +LE D LWS + L+E P+LI +VH + AG T Sbjct: 4 GKPLVLDGGLGIQLETLAEKRNFAVKNDPLWSGRALIEAPDLIEDVHKSFLEAGCDIVTT 63 Query: 69 ASYQATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGA 127 ++YQ + A +AQ + L KSV++ +A + + + V G++GPYG Sbjct: 64 STYQISRASLKKYTDFTDAQIEELWAKSVDVCWQACKFHES------KARVCGAIGPYGG 117 Query: 128 YLADGSEYRGDYH-CSVEAFQAFHRPRVEAL-LDAGADLLACETLPNFSEIEALAELLTA 185 +LA+ +EY G+Y + + +H P L + D+LA ET+PN+ E++ + L+ Sbjct: 118 FLANYAEYTGEYGLITNHKLEQYHLPLATFLNNNPKVDILAFETIPNYKELKVIVNLVCK 177 Query: 186 Y----PRARAWFSFTLRDSEHLSDGTPLRDVVALLAG--------YPQVVALGINCIALE 233 P + S R+S +SDGTP+ ++ L G +++A+G NC L+ Sbjct: 178 MSATGPLKPFYLSMNFRNSSQMSDGTPIEKIMGYLNGKLNKNRTLRKRLIAIGCNCTELK 237 Query: 234 NTTAALQHLH--GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARL 291 + T L+++ +P +VYPN ++ + + + + +W GA + Sbjct: 238 DATHVLKNIETYNYHNIPTIVYPNVFADHN--------DTKIDQKWSQSVDEWLKIGASI 289 Query: 292 IGGCCRTTPADIAALK 307 IGGCC T P IA ++ Sbjct: 290 IGGCCGTGPKQIAQIR 305 >UniRef50_Q15S12 Homocysteine S-methyltransferase n=1 Tax=Pseudoalteromonas atlantica T6c RepID=Q15S12_PSEA6 Length = 304 Score = 239 bits (611), Expect = 7e-62, Method: Composition-based stats. Identities = 78/302 (25%), Positives = 124/302 (41%), Gaps = 24/302 (7%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 I +LDG M EL R +WSA +++ PEL+R++H ++ +GA+ +Y ATP Sbjct: 12 ITILDGGMGQELLRRSSRDVTPMWSADIMLNEPELVRDLHREFINSGARVITLNTYTATP 71 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 E L ++ A++A Q +++AGS+ P A Y Sbjct: 72 QRLKRENQFEQFVH-LHDAAMRAAQEAIAL-----TQRDDVMIAGSLPPLVA------SY 119 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 + S E +R ++ AL G+D+ CET+ + E +A W +F Sbjct: 120 HPEVSLSFEDSLVSYR-QLVALQSLGSDIFICETMSSICEAQAACTAAKE-SGKPVWVAF 177 Query: 196 TLRDS--EHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVY 253 T+ D+ + L G L+D + L A+ +NC E +A L + + Y Sbjct: 178 TVSDTEPDQLRSGELLKDALDALKALS-PDAIMLNCSLPEAI-SACWSLMQQSNAKIGAY 235 Query: 254 PNSG------EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 N D V + Q A + W GA +IGGCC P I AL Sbjct: 236 ANGFVSIDALYPGDTVEELEMRKDMSPEQYAAHAMHWVQNGASIIGGCCEIGPDHIKALH 295 Query: 308 AR 309 ++ Sbjct: 296 SK 297 >UniRef50_C9M596 Vitamin B12-dependent methionine synthase family protein n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M596_9BACT Length = 808 Score = 239 bits (611), Expect = 8e-62, Method: Composition-based stats. Identities = 65/304 (21%), Positives = 117/304 (38%), Gaps = 24/304 (7%) Query: 4 NNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGA 63 +P R L +D ++ DGAM T L +RG ++ + +PE + VH + AG+ Sbjct: 6 TSPSRRLTLGRDRIIFDGAMGTALGSRGLRRGS--LPEELNLSSPETVAAVHRSFLEAGS 63 Query: 64 QCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVG 123 T ++ A P+ A GL ++ + ++AR+ E + VA +G Sbjct: 64 DFITTNTFGAFPSRLAHAGLS---VGPVVRSACQIARREAERFGG--------FVALDIG 112 Query: 124 PYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 P G + + + + + A A D + ET + +EI A A + Sbjct: 113 PSGRLMEPLGD------ATFDEIYQGVCEVLHAGA-AYCDAVLLETFTDLAEIRAAALAV 165 Query: 184 TAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHL 242 + + S G + +L+ A G NC ++ + Sbjct: 166 RENCGLPLLATMSFEPSGRTFSGAS-AEACSLVLSGLGASAFGTNCSAGPRALRETVRQI 224 Query: 243 HGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPAD 302 G +P++V PN+G + S + + + ++ G ++GGCC TTP Sbjct: 225 CGACPVPVIVQPNAGLPEFSGSSVV--YSAGPDEFQSVMGEFARWGVAVLGGCCGTTPDY 282 Query: 303 IAAL 306 I L Sbjct: 283 IRRL 286 >UniRef50_C4QA25 Putative uncharacterized protein n=1 Tax=Schistosoma mansoni RepID=C4QA25_SCHMA Length = 741 Score = 237 bits (606), Expect = 3e-61, Method: Composition-based stats. Identities = 95/337 (28%), Positives = 148/337 (43%), Gaps = 43/337 (12%) Query: 15 DILLLDGAMATELEARGCNLADSL--WSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 +I +LDG TE + D WS+++L+++PEL+ ++H + RAG T +YQ Sbjct: 396 EIRVLDGGFGTESQKLSNLQIDGHLAWSSRLLMDDPELVVKIHKSFLRAGCDVISTNTYQ 455 Query: 73 ATPAGFAAR-GLDEAQSKALIGKSVELARKAREA-----YLAENPQAGTLLVAGSVGPYG 126 A P+ G+ ++K L+ +V LA++ARE +E + +L+AGS+GPYG Sbjct: 456 AAPSTLGKALGISIGEAKNLMHTAVHLAQRAREEENNSVTASEFQRKLPVLIAGSLGPYG 515 Query: 127 AYLADGSEYRGDYH--CSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 A ADGSEY G Y S FH R + LL++G D +A ET+P E+ ++ E++ Sbjct: 516 ACAADGSEYTGSYANEVSFNELVEFHLSRAKILLESGVDFIAWETVPLLKEVSSICEVMR 575 Query: 185 AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIAL-ENTTAALQHLH 243 P A W S + D E S G L V +A QV +G+NC + L +L+ Sbjct: 576 RLPSAYCWISVSSPDGEKTSGGDLLASVACEVAKCEQVFGVGVNCNIPHDCIGKGLANLN 635 Query: 244 GLT--------VLPLVVYPNSGEHYDAV------SKTWHHHGEHCAQLADYLPQWQA--- 286 T ++ Y N G+ + ++ + QW Sbjct: 636 SQTCKESENTSSKLILFYANDGQLWIPNDGDKKRGHFVNYSQYNHDSWFQNTIQWAKRRE 695 Query: 287 ---------------AGARLIGGCCRTTPADIAALKA 308 A+ +GGCC P I L Sbjct: 696 TSDDEHLHYSVNDKPPLAQWVGGCCNVRPECIRRLAK 732 >UniRef50_C3PEG0 Homocysteine S-methyltransferase n=3 Tax=Corynebacterium RepID=C3PEG0_CORA7 Length = 292 Score = 237 bits (606), Expect = 3e-61, Method: Composition-based stats. Identities = 112/293 (38%), Positives = 153/293 (52%), Gaps = 10/293 (3%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 LLLDG + T LEA+G +++ LWSA+VL ENP L+ H D++ AGAQ A TASYQ T Sbjct: 7 PLLLDGGLGTHLEAQGHDISGPLWSARVLRENPTLLESAHADFFAAGAQVATTASYQVTF 66 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 ++AL+ +SV +AR+A + ++ G LLVA S+GPYGA G++Y Sbjct: 67 DVLGE------DAEALLRRSVAVAREAVRVAVDKHTAHGDLLVAASIGPYGAGPGKGTDY 120 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 G Y Q +H R+ L D AD L ET+PN E AL ELL A P S Sbjct: 121 DGAYDLRRGELQRWHARRIAVLADTDADFLLAETIPNVDEAAALLELLKAQP-KPFALSI 179 Query: 196 TLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYPN 255 T +D L V+ L ++ ALG+NC++ A + L T PL+ PN Sbjct: 180 T---GAIAADQAKLSQVIELANQSSRLGALGVNCVSPSQARAVVATLRAGTDKPLLACPN 236 Query: 256 SGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 SGE +D + W L + Q +AAG ++GGCCR PA+I L+ Sbjct: 237 SGEVWDCTAHDWQPAPADAMSLPEAALQLRAAGVSVLGGCCRVGPAEIRQLRR 289 >UniRef50_UPI0001AEC485 homocysteine S-methyltransferase family protein n=1 Tax=Alteromonas macleodii ATCC 27126 RepID=UPI0001AEC485 Length = 308 Score = 237 bits (604), Expect = 6e-61, Method: Composition-based stats. Identities = 87/306 (28%), Positives = 123/306 (40%), Gaps = 26/306 (8%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 DIL+LDG M EL+ G WSA L++ PEL+ +VH + AGA T +Y Sbjct: 10 DILILDGGMGRELKKTGAPFKQPEWSALALMQTPELVSDVHKRFLEAGACVITTNAYALV 69 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 P E Q+ L + ELAR A A ++ VAGSV P Sbjct: 70 PFHIGENTFRE-QAFTLAQNAAELARGAVNALKSDG--DNKRFVAGSVPP------AFGS 120 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 YR D P ++A + D+ ET + E EA+ L+ Y W S Sbjct: 121 YRPDLF-DATRVADILTPLIKA-QEPYVDVWLIETASSVEEAEAVVSLIKQYSSLPLWLS 178 Query: 195 FTLRDSE------HLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL-TV 247 F++ + E L G PL ++ +L +V ++ NC E A+ L T Sbjct: 179 FSVSNRETSNEPVTLRSGEPLSEIAPIL---SEVQSVLFNCSQPEEMEDAISITRSLDTS 235 Query: 248 LPLVVYPNSGEHYDAVSKT-----WHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPAD 302 + + Y NS A+ +Y+ W AAGA +IGGCC P Sbjct: 236 INIGAYANSFSERKRTHAANALLSEIRDDITPARYVEYVKTWVAAGATIIGGCCGIGPEH 295 Query: 303 IAALKA 308 I A+ Sbjct: 296 IKAISD 301 >UniRef50_C8WWX3 Methylenetetrahydrofolate reductase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WWX3_ALIAD Length = 637 Score = 236 bits (603), Expect = 6e-61, Method: Composition-based stats. Identities = 65/300 (21%), Positives = 110/300 (36%), Gaps = 31/300 (10%) Query: 17 LLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPA 76 ++ DGAM+T L G + + ++ + +P+L+ VH Y +G T ++ Sbjct: 20 VIFDGAMSTYLHQLGVPIGTPV--EQLNLTSPDLVARVHRRYVESGCTVLQTNTFMGNRI 77 Query: 77 GFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP------YGAYLA 130 GL ++L + VE+AR A V G++GP YGA L Sbjct: 78 ALERHGLT-VDVQSLNRRGVEIARSAA---------RDEASVYGTMGPAMGGYRYGALLQ 127 Query: 131 DGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA-YPRA 189 D + + + EAL+ AG D L ET P+ E + Sbjct: 128 DE---------ERDLLARVYAEQAEALVSAGIDGLILETFPDLEEALVAIAAVRPILGDL 178 Query: 190 RAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVL 248 + + + DG PL + + +G+NC + + + Sbjct: 179 PLVVNLSPEEIGVTRDGVPLAEAFRRIKA-AGADVVGLNCRLGPYGILRSYEQAGVAADG 237 Query: 249 PLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 P PN+G + + G+ + + + G R +GGCC TTP I L+ Sbjct: 238 PYAAVPNAGILQRSEGDEIAYTGDTAD-FSRLMLRIAQLGVRWLGGCCGTTPEYIRTLRD 296 >UniRef50_A1SWN6 Homocysteine S-methyltransferase n=1 Tax=Psychromonas ingrahamii 37 RepID=A1SWN6_PSYIN Length = 310 Score = 234 bits (598), Expect = 3e-60, Method: Composition-based stats. Identities = 83/314 (26%), Positives = 128/314 (40%), Gaps = 42/314 (13%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 ++LDG M EL+ G WSA+ L+E+P I EVH + AGA+ T +Y P Sbjct: 16 PIILDGGMGRELKRIGAPFQQPEWSAQALIESPHFISEVHKSFIEAGAEVITTNTYALVP 75 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 + +E + LI + LAR+ + A +LVAG + P Y Sbjct: 76 FHIGEKRFNEQGA-DLIKLAARLARECVKENSA-------VLVAGCIPPV------LGSY 121 Query: 136 RGDYHCSVEAFQAFHRPRVEALL---DAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 R D +A +P +E L+ +A D+ ET+ + +E A+ + T W Sbjct: 122 RPDLFSVEKA-----KPVLELLIKNQEADVDIWLAETISSIAEA-AMIKARTVVTNKPTW 175 Query: 193 FSFTLRDSEH----LSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL--- 245 +FT++D L G + D V+ +AG V A+ NC +E AL Sbjct: 176 IAFTIKDEITTEPALRSGESVYDAVSQIAGQ-NVSAILFNCSGVEVMETALITAKQALLD 234 Query: 246 ----TVLPLVVYPNSGEHYDAVSKTWH-------HHGEHCAQLADYLPQWQAAGARLIGG 294 + L VY N+ + + + ++ W AGA +IGG Sbjct: 235 KEIEDQVQLGVYANNFPPIGELHQANQDHGVSGIRDDVPPEKYHEFGLSWINAGASIIGG 294 Query: 295 CCRTTPADIAALKA 308 CC +PA I L Sbjct: 295 CCGVSPAHIKKLAE 308 >UniRef50_D0LSQ2 Methylenetetrahydrofolate reductase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LSQ2_HALO1 Length = 643 Score = 234 bits (596), Expect = 4e-60, Method: Composition-based stats. Identities = 80/310 (25%), Positives = 124/310 (40%), Gaps = 26/310 (8%) Query: 1 MSQNNPLRALLDK--QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDY 58 MS + L+ L+ Q LL DGAM + L RG + ++ + P+LIR VH +Y Sbjct: 1 MSGTSCLKPFLEALAQGPLLFDGAMGSLLYDRGVFHTRNY--DELSLSQPKLIRAVHREY 58 Query: 59 YRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLV 118 AGAQ T ++ A A G E + + +VE+AR + V Sbjct: 59 LEAGAQILETNTFGANRIKLTAHGHSE-RVADINRAAVEMARSVAD---------DRAYV 108 Query: 119 AGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 AG+VGP G Y + +++ L++AG DLL ET E+EA Sbjct: 109 AGAVGPTGIR------YTIAPAAERKRAIEALGEQIDYLVEAGVDLLCLETFGAILELEA 162 Query: 179 LAELLTA-YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTT 236 EL P L +G VA A+G NC + Sbjct: 163 AIELARQIAPEMPVVAHLVFDADG-LVEGELDGATVAQRLIAAGANAVGANCGVGPPELY 221 Query: 237 AALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCC 296 A + + P+ + PN+G + +T + + + + +G R++GGCC Sbjct: 222 AVGTKMSDV-GAPVSIQPNAGFPSNIDGRTI--YVANPEHFGVFARRMLKSGVRMVGGCC 278 Query: 297 RTTPADIAAL 306 TTP + A+ Sbjct: 279 GTTPEHVRAM 288 >UniRef50_B7AQD9 Methylenetetrahydrofolate reductase n=1 Tax=Bacteroides pectinophilus ATCC 43243 RepID=B7AQD9_9BACE Length = 603 Score = 233 bits (595), Expect = 6e-60, Method: Composition-based stats. Identities = 66/308 (21%), Positives = 114/308 (37%), Gaps = 29/308 (9%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 LR L L+ DGAM T ++ +E P++I +H +Y AG Sbjct: 1 MMESLREYLKGHR-LITDGAMGTYYSE--ITNNPEAFAEFANIERPDIIERIHNEYIDAG 57 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 A+ T ++ A G+ + K LI + +A++ + G VAG + Sbjct: 58 AKLIRTNTFAANTQML---GIGRDELKKLIEDACRIAQRCAD---------GRAYVAGDI 105 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP + S + ++ + LD D + ET +F +I+ +AE Sbjct: 106 GPI-----------KENAESEGSAVEEYKMICDIFLDMKVDAIRFETFADFDDIKEVAEY 154 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQH 241 + + F L + + G ++ + + G NC I + +Q Sbjct: 155 VRSKSDMFIMADFCLNKNGFTAGGISAARIMQQAGQMDCIDSCGFNCGIGSGHMNNIMQK 214 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 L + PN+G ++ + + D + + A G +IGGCC T PA Sbjct: 215 LTFAKDKYMSCLPNAGYPEQMNNRMV--FMNNASYFCDNMQKISAYGMNIIGGCCGTKPA 272 Query: 302 DIAALKAR 309 I L R Sbjct: 273 YIRELCRR 280 >UniRef50_Q1AXR8 Methylenetetrahydrofolate reductase n=2 Tax=Bacteria RepID=Q1AXR8_RUBXD Length = 611 Score = 233 bits (594), Expect = 6e-60, Method: Composition-based stats. Identities = 82/307 (26%), Positives = 120/307 (39%), Gaps = 22/307 (7%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 R LLD +L+ DGAM T L RG A+ + +PEL+ +H +Y RAG Sbjct: 1 MGTSFRDLLD-GRVLVGDGAMGTLLADRGVGYGHPY--ARANLTHPELVERLHGEYVRAG 57 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 A+ T ++ A A L E + + + AR A A A +LV G++ Sbjct: 58 ARAIETNTFSANRIKLAGHRL-EERVREINEA------GARLARRAAAEAAERVLVLGAI 110 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G LA E +A R + EALL+ G+D L ET + E+ E Sbjct: 111 GPLGRPLAPVGRVP------REEARALFREQAEALLEGGSDALLLETFTDLEELRLAWEA 164 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQH 241 + A T + ++G+ V +G NC + ++ Sbjct: 165 VRDL-GAPVLAYKTFVEDGETLAEGLPERAAREISGW-GVELVGSNCTVGPQRMLGIVEQ 222 Query: 242 LHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPA 301 + P+ +PN G + A Y + AGAR +GGCC TTP Sbjct: 223 MSAAAG-PVAAFPNPGLPQLVEGTV--RYSHDVEHFARYGLRLAEAGARFVGGCCGTTPE 279 Query: 302 DIAALKA 308 I AL Sbjct: 280 HIRALSE 286 >UniRef50_B1HTR8 Methylenetetrahydrofolate reductase n=95 Tax=Bacilli RepID=B1HTR8_LYSSC Length = 647 Score = 232 bits (592), Expect = 1e-59, Method: Composition-based stats. Identities = 70/306 (22%), Positives = 114/306 (37%), Gaps = 27/306 (8%) Query: 3 QNNPLRALLD--KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 + LL+ K +L DGA+ T L G ++ V+ PELI ++H +Y Sbjct: 28 REARFMGLLERLKTHVLTADGAIGTVLYGYGLE----YCHEEMNVQRPELIEKIHREYIA 83 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGA T +Y A A GL E+ + ++ +A++A G V G Sbjct: 84 AGADIIQTNTYGANAIKLARYGL-ESSVQRFNEAAITIAKRAAA--------DGGQFVLG 134 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALA 180 ++G ++ + LL D L ET +F E+ A Sbjct: 135 TIGGIRGIRKS--------DATLNDILKTVEEQASVLLAGNPDGLLLETYYDFEELTATL 186 Query: 181 ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAAL 239 ++L A ++ + L +G L + L +G+NC + +T A Sbjct: 187 KMLRAKTNIPIIAQVSMHEPGVLQNGMSLNIALHELE-ILGADIVGVNCRLGPYHTIQAF 245 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 + + + YPN+ + + + + G RLIGGCC TT Sbjct: 246 EGVELPEKAFMSAYPNASLLDLEDGRVV--YESEADYFGRAAVELRDQGVRLIGGCCGTT 303 Query: 300 PADIAA 305 P IAA Sbjct: 304 PKHIAA 309 >UniRef50_A4WQF1 Homocysteine S-methyltransferase n=39 Tax=Alphaproteobacteria RepID=A4WQF1_RHOS5 Length = 357 Score = 232 bits (591), Expect = 2e-59, Method: Composition-based stats. Identities = 69/310 (22%), Positives = 113/310 (36%), Gaps = 21/310 (6%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRA 61 + L +L ++ L+ DGA T L G + + ++ P+ IR ++ A Sbjct: 22 KMTDALSRMLQTREWLMADGATGTNLFNMGLSSGEP--PELWNIDRPDNIRALYRAAVEA 79 Query: 62 GAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGS 121 G+ +T S+ A + + L + EL R+ + T++VAGS Sbjct: 80 GSDIFLTNSFGGNAARLKLH-EAQGRVGELNRTAAELGREVAD------ASGRTVVVAGS 132 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 +GP G + EAL GAD+L ET+ A Sbjct: 133 MGPTGEIFEPMGTLTHRM------AVEIFHEQAEALKAGGADVLWVETISAAE-EFKAAA 185 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQV-VALGINCI--ALENTTAA 238 + + + G +V L+ P +A G NC A + Sbjct: 186 EAARLAGMPWCGTMSFDTAGRTMMGLTPAALVDLVTKLPNPPLAFGANCGVGASDLLRTV 245 Query: 239 LQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRT 298 L LP++ N+G H+ +A+Y + AGAR+IGGCC T Sbjct: 246 LGFTAQGVELPVIAKGNAGIPKYHDGH--IHYDGTPDLMAEYAVLARDAGARVIGGCCGT 303 Query: 299 TPADIAALKA 308 P + A++A Sbjct: 304 MPEHLRAMRA 313 >UniRef50_UPI0001BC6543 5-methyltetrahydrofolate--homocysteine methyltransferase n=2 Tax=Fusobacterium RepID=UPI0001BC6543 Length = 290 Score = 231 bits (589), Expect = 3e-59, Method: Composition-based stats. Identities = 72/304 (23%), Positives = 123/304 (40%), Gaps = 34/304 (11%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K+ IL+LDGAM T L + G + LI+++H Y AGA T S+ Sbjct: 7 KRRILVLDGAMGTMLASYGEKP----CYEVLNKTKENLIQKIHEKYIEAGADIITTNSFN 62 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 L E+ L KSVE+A+KA + + GS+GP A L + Sbjct: 63 CNQMALQKYHLKES-VYDLTKKSVEIAKKA------TKNSKKAVYILGSIGPSIANLPE- 114 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY-----P 187 +++++ + ++ LLD G D L ET+ + ++ + ++ Sbjct: 115 ---------DMKSWKQSYFQQILGLLDGGVDALLLETIYDENKANCILGIIEEVLQAGKR 165 Query: 188 RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLT 246 + S T+ + L GT + V + P +V G+NC +EN + L L T Sbjct: 166 EIPVFCSMTINQNGKLLTGTSITRAVEKM-DRPWIVGFGLNCSYGMENVVSFLPELIWAT 224 Query: 247 VLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG-ARLIGGCCRTTPADIAA 305 +VY N+G + + E+ ++ + L + ++GGCC T A Sbjct: 225 DKYCMVYANAGFPNEKG-----EYTENIEEMLELLQPFLEKHLIHIVGGCCGTNEKYTYA 279 Query: 306 LKAR 309 + Sbjct: 280 FAKK 283 >UniRef50_A7TSR2 Putative uncharacterized protein n=1 Tax=Vanderwaltozyma polyspora DSM 70294 RepID=A7TSR2_VANPO Length = 323 Score = 231 bits (589), Expect = 3e-59, Method: Composition-based stats. Identities = 93/329 (28%), Positives = 149/329 (45%), Gaps = 33/329 (10%) Query: 3 QNNPLRALLDKQ--DILLLDGAMATELEARGCNLADSLWSAKVLV-----------ENPE 49 P+ L+ Q ++L+ DG + T LE+RG N++ LWS + + Sbjct: 1 MRVPIEELIRNQPDEVLVSDGGLGTLLESRGINVSSPLWSTVPFLKDDFWDSETKTSDRN 60 Query: 50 LIREVHLDYYRAGAQCAITASYQATPAGFAARGL--DEAQSKALIGKSVELARKAREAYL 107 +I ++ DY +G++ T +YQ + A + K LI R A Sbjct: 61 IIEGIYRDYITSGSRILSTITYQTSFALISTHTEVKTIEGYKQLIRNITSFCRSAI---- 116 Query: 108 AENPQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAF--QAFHRPRVEALLDAG-ADL 164 + GS+GP+GA L G+EY G+Y S + +P++E + D+ Sbjct: 117 -----GEDNYLIGSIGPFGARL--GAEYTGNYGDSPSNINYLEYFKPQLEEFNNNDDIDI 169 Query: 165 LACETLPNFSEIEALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVA 224 + ET+PN E+EA+ + + S +L D+ L DGT ++ + Y Sbjct: 170 IGFETVPNKYELEAILSWDKSVISKPYYVSLSLLDNGGLRDGTSFEEIATIFKKYSNNDN 229 Query: 225 L---GINCIALENTTAALQHLHGL-TVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADY 280 L G NCI+ + + + LH LPL+VYPNSGE YD ++K W D Sbjct: 230 LILTGANCISFKYASENISKLHQAIPTLPLIVYPNSGEIYDPLTKKWTIDQTFGLTWEDL 289 Query: 281 LPQWQAAGARLIGGCCRTTPADIAALKAR 309 + + + + R++GGCCRTTP DI +K Sbjct: 290 IKELRTSNVRIVGGCCRTTPDDINKIKDM 318 >UniRef50_Q0SIE4 Methionine synthase n=23 Tax=Bacteria RepID=Q0SIE4_RHOSR Length = 1189 Score = 231 bits (589), Expect = 3e-59, Method: Composition-based stats. Identities = 65/323 (20%), Positives = 122/323 (37%), Gaps = 32/323 (9%) Query: 3 QNNPL-RALLD--KQDILLLDGAMATELEARGCNLADSL----WSAKVLVENPELIREVH 55 + P ALLD Q +++ DGAM T L+A L D L + + P++++++H Sbjct: 1 MSAPFHSALLDALNQRVVIGDGAMGTMLQAADLTLDDFLGLEGCNEILNDTRPDVLKDIH 60 Query: 56 LDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGT 115 Y+ AGA T ++ A + + + + L K LAR + + Sbjct: 61 RAYFEAGADAVETNTFGCNLPNLADYDISD-RIRELAEKGTRLARDVADE-MGPGRDGMG 118 Query: 116 LLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSE 175 V GS+GP G++ H + + ++D GAD + ET + + Sbjct: 119 RFVLGSMGP-------GTKLPTLGHAPFAILRDAYAEAAMGMIDGGADAILVETCQDLLQ 171 Query: 176 IEALAELLTAY-----PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC- 229 ++A R T+ + + G+ + + L + +G+NC Sbjct: 172 VKAAILGSQRAMETLGSRLPIITHVTVETTGTMLLGSEIGAALTALEPL-GIDMIGLNCA 230 Query: 230 IALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLAD----YLPQWQ 285 + L+HL + LP+ V PN+G + + +LA+ ++ ++ Sbjct: 231 TGPAEMSEHLRHLSKYSSLPVSVMPNAGLPQLGPNGA--EYPLTAEELAEALSGFVTEFG 288 Query: 286 AAGARLIGGCCRTTPADIAALKA 308 TTP I + Sbjct: 289 LGLVGGCC---GTTPEHIRQVAE 308 >UniRef50_C3MDS4 Homocysteine S-methyltransferase, putative n=12 Tax=Bacteria RepID=C3MDS4_RHISN Length = 352 Score = 230 bits (587), Expect = 4e-59, Method: Composition-based stats. Identities = 82/313 (26%), Positives = 130/313 (41%), Gaps = 24/313 (7%) Query: 1 MSQN---NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLD 57 M + N L LL ++ +LL DGA T L A G ++ PE I ++H D Sbjct: 13 MPMSIAANALSDLLAQKGVLLADGATGTSLFAMGLEAGEA--PELWNETKPENITKLHQD 70 Query: 58 YYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLL 117 + AGA +T S+ T E + AL ++ E+AR + ++ Sbjct: 71 FVDAGADIILTNSFGGTRHRLKLH-QAEDRVHALNKRAAEIARAVADK------APRKVI 123 Query: 118 VAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE 177 AGSVGP G L S E + ++E L GA++ ET+ + EI Sbjct: 124 TAGSVGPTGELLIPLG------ALSYEDAVSAFAEQIEGLKAGGAEVAWIETMSSPDEIR 177 Query: 178 ALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYP-QVVALGINC-IALENT 235 A AE T ++ + + G +D+ + A VA+G NC + + Sbjct: 178 AAAEAATKV-GLPFVYTGSFDTAGKTMMGLHPKDLHTVAAEIGEGPVAVGANCGVGASDI 236 Query: 236 TAALQHLHGLTV-LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGG 294 ++L + +VV N G S+ H+ +A+Y AGAR+IGG Sbjct: 237 LSSLLDMTAANPEGTVVVKGNCGIPEFRGSE--IHYSGTPPLMAEYARLAVDAGARIIGG 294 Query: 295 CCRTTPADIAALK 307 CC T+ +AA++ Sbjct: 295 CCGTSCNHLAAMR 307 >UniRef50_B0PG09 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PG09_9FIRM Length = 406 Score = 230 bits (586), Expect = 5e-59, Method: Composition-based stats. Identities = 70/293 (23%), Positives = 107/293 (36%), Gaps = 31/293 (10%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 LLLDGA TE G + + E+P+++ V Y AG+ ++ A Sbjct: 12 PLLLDGATGTEYMKAGLPSG--VCVEQWAAEHPDVVARVARGYADAGSDIVYAPTFLANA 69 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 GL E Q L K V ++A +LVAG + G E Sbjct: 70 GNLKNYGLSE-QVIPLNRKIVSTVKQALA--------GRDVLVAGDMSTTGLMCEPFGE- 119 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 + + AL DAGA+LL ET+ SE A + + Sbjct: 120 -----TEFVHLIGIYAEQASALADAGAELLVIETMSALSECRAAVIAARQ-TGLPVFLTM 173 Query: 196 TLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQHLHGLTVLPLVVYP 254 T+ G + + +L + A G+NC ++ + + LPL+ P Sbjct: 174 TVDAEGRTMWGDDVLASMIVLQDM-GISAFGLNCSQGPDDMVPLFERIAPYAKLPLIAKP 232 Query: 255 NSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 N+GE Q D + G ++IGGCC TTP ++AL+ Sbjct: 233 NAGEP-----------PLSPVQFCDKCARLMRRGVKIIGGCCGTTPEYVSALR 274 >UniRef50_D1N227 Methylenetetrahydrofolate reductase n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N227_9BACT Length = 605 Score = 230 bits (586), Expect = 6e-59, Method: Composition-based stats. Identities = 78/299 (26%), Positives = 129/299 (43%), Gaps = 29/299 (9%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 + + + DGA+ TE+ R + S ++ + P++I ++H Y +AGA+ T +Y A Sbjct: 10 ESLTIFDGAIGTEIYRRNFFVNASF--EQLNLTAPDVILDIHHQYLKAGAEVLTTNTYNA 67 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 A GL E Q++A+ V+LAR+A SVGP G Sbjct: 68 NSRRLAKFGLSE-QTEAINRAGVKLAREAAAGKALVAA---------SVGPVG------- 110 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWF 193 D ++ AL D AD + E+L ++++A+ E + +P Sbjct: 111 --EPDSDQDRRTRAELLAEQIRALSD--ADFIIFESLRRAADLKAVLEAVAEFPELVYVP 166 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAG---YPQVVALGINC-IALENTTAALQHLHGLTVLP 249 SF + H++D + + + L P A+G+NC E+T L+ L LT LP Sbjct: 167 SFAIEPHPHINDSATIAEFMEQLNASRPCPAPTAIGLNCGGGPESTLGVLEELTALTQLP 226 Query: 250 LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 ++V PN+G+ + + + Y ++ GA IGGCC TP I L Sbjct: 227 VIVQPNAGQPKGVDGR--MIYMTSAEYFSTYAKRYAMLGAAAIGGCCGITPDHIEELAR 283 >UniRef50_Q0TQI2 Homocysteine S-methyltransferase family protein n=9 Tax=Clostridium perfringens RepID=Q0TQI2_CLOP1 Length = 279 Score = 230 bits (586), Expect = 6e-59, Method: Composition-based stats. Identities = 71/302 (23%), Positives = 125/302 (41%), Gaps = 25/302 (8%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 ++ L K +++ DGAM T + G NL D+ S + ++ PELI ++H +Y +GA Sbjct: 1 MKNLDLKNGVIIADGAMGTRIMELGVNLKDTP-SELLNIKKPELIEKIHREYIESGANLI 59 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 ++ ++ + + ++G + +A+KA LVA +GP Sbjct: 60 LSNTFMCNIINAKRNNYN---LEEVVGAGIHIAKKAC---------GDGGLVALDIGPLS 107 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 Y+ + S + + R+ DL+ ETL + E E + Sbjct: 108 YYIEENDS-------SFKEIVYENTERIINASKDKFDLVIFETLGSLKEGEFAVKKAKTL 160 Query: 187 PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLT 246 + SFTL + + + ++++V+ L V ALGINC E AL L Sbjct: 161 TDKKVICSFTLAYKKDIPN--FIKNMVSTLEPL-GVDALGINCTGYEEILIALDILKENI 217 Query: 247 VLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 LP+++ N G + + + + + + G +IGGCC TTP I A+ Sbjct: 218 NLPIMIKANLGIPKKVGEELV--YDKTLEEFKNLSKRALEKGVNIIGGCCGTTPEYIRAI 275 Query: 307 KA 308 Sbjct: 276 CN 277 >UniRef50_C1C2Y0 Homocysteine S-methyltransferase 1 n=1 Tax=Caligus clemensi RepID=C1C2Y0_9MAXI Length = 391 Score = 230 bits (586), Expect = 7e-59, Method: Composition-based stats. Identities = 85/333 (25%), Positives = 141/333 (42%), Gaps = 49/333 (14%) Query: 8 RALLDKQDILLLDGAMATELEARGCN---LADSLWSAKVLVENPELIREVHLDYYRAGA- 63 R L + +I +LDG +T+++ W++++ ENPE ++ H+DY + Sbjct: 11 RVLGSRNEIFILDGGFSTQIQQHAGKDSFEGRPQWTSELNTENPEAVKRSHMDYLSNCSG 70 Query: 64 QCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVG 123 + +YQA + I K+VEL +A +AG + GS+G Sbjct: 71 DLISSNTYQAASSS--------------IEKAVELCDEAILEASHVPRKAG---IVGSLG 113 Query: 124 PYGAYLADGSEYRGDYHCSV-----EAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 PY A+ GSEY S E + +++ R+ L+ AG D++A ET+P E Sbjct: 114 PYAAFQPSGSEYNSSDGMSYPPLADEELKEWYKDRIRHLMIAGVDVIAFETMPCIKEALV 173 Query: 179 LAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVV-----ALGINCIALE 233 +++ A+ W SF RD +HL+ G +D V L +P V +GINC + + Sbjct: 174 ALDIIDNVINAKCWISFQCRDGKHLAYGESFKDAVERLLNHPAFVKRKLLYIGINCTSPK 233 Query: 234 NTTAALQHLH------------GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHC-----AQ 276 ++ L+ G +P VVYPN G Y + + Sbjct: 234 YISSLLKLAERVNKKMNFPDKYGYWRIPYVVYPNRG-VYCKEKCCYVLDKDDPLGGGDEG 292 Query: 277 LADYLPQWQAAGARLIGGCCRTTPADIAALKAR 309 + +W G R+IGGCC I ++ + Sbjct: 293 ILKRCHEWMLLGTRVIGGCCGVDANLIKEIRNQ 325 >UniRef50_D2R929 Homocysteine S-methyltransferase n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2R929_9PLAN Length = 293 Score = 229 bits (584), Expect = 9e-59, Method: Composition-based stats. Identities = 84/295 (28%), Positives = 122/295 (41%), Gaps = 25/295 (8%) Query: 20 DGAMATELEARGCNLADSLWSAKVLVENP--ELIREVHLDYYRAGAQCAITASYQATPAG 77 DGA TEL RG + +WSA L + ++R++HLDY +AGA +++ Sbjct: 16 DGATGTELNRRGLDTGLPMWSANALTTDTGLNVLRQIHLDYLQAGADILTANTFRTHRRA 75 Query: 78 FAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYRG 137 A+ ++ L ++V A++A + VAGSV P YR Sbjct: 76 LAS---KVHAARELTMRAVATAQEAIAEFGQAAQ------VAGSVSPL------EDCYRP 120 Query: 138 DYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSFTL 197 D + +A H R++ L+DAG DLL ET+ + E A+L SF Sbjct: 121 DLVPPDDMCRAEHSERIQHLVDAGVDLLLIETMSSIREAVIAAKLA-TITGLPTLVSFVC 179 Query: 198 RDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLT--VLPLVVYPN 255 + G P+ LL V ALG+NC L L + PL+ Y N Sbjct: 180 DGEGRILSGEPVAVAAELLLPL-GVKALGVNCGPAHTLAKPLVELRRICGPDFPLIAYGN 238 Query: 256 SGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKARS 310 G D + E + W A+++GGCC TTPA I L+ RS Sbjct: 239 IGY-ADEAQGWINTDAESPESYLHHAETWP---AQILGGCCGTTPAHIRRLRVRS 289 >UniRef50_B4RRL7 Homocysteine S-methyltransferase family protein n=1 Tax=Alteromonas macleodii 'Deep ecotype' RepID=B4RRL7_ALTMD Length = 305 Score = 229 bits (583), Expect = 1e-58, Method: Composition-based stats. Identities = 85/308 (27%), Positives = 122/308 (39%), Gaps = 26/308 (8%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 + I +LDG M EL+ G WSA L+++PEL+ +VH + AGA T +Y Sbjct: 5 DKAIQILDGGMGRELKKIGAPFRQPEWSALALMQSPELVSDVHTHFLNAGATVITTNTYA 64 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 P + +E Q+ L + +LAR A A ++ Q G L VAG + P Sbjct: 65 LVPFHIGEQTFNE-QAFKLAETAAKLARDAVNA--QQDKQEGNLSVAGCIPP------AF 115 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 YR D P +EA D+ ET + E EA+ L+ W Sbjct: 116 GSYRPDLF-DASRVSEILMPLIEA-QAPYIDVWLIETASSIEEAEAVVSLIKTLSSRPIW 173 Query: 193 FSFTLRDSE------HLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLT 246 SF+L + L G PL +V +L V + NC E +A+ L Sbjct: 174 LSFSLHNRASTDEPVTLRSGEPLEKIVPVLRD---VERVLFNCSQPEEMESAITITRKLN 230 Query: 247 -VLPLVVYPNSGEHYDAVSKT-----WHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTP 300 + + Y NS + A+ DY+ W AAGA +GGCC P Sbjct: 231 PNIAIGAYANSFSERKRSHQANALLSELRDDVTPARYLDYVKSWIAAGASTVGGCCGIGP 290 Query: 301 ADIAALKA 308 I A+ Sbjct: 291 EHIKAISE 298 >UniRef50_Q2S678 Vitamin B12-dependent methionine synthase family protein n=1 Tax=Salinibacter ruber DSM 13855 RepID=Q2S678_SALRD Length = 320 Score = 227 bits (580), Expect = 3e-58, Method: Composition-based stats. Identities = 89/313 (28%), Positives = 133/313 (42%), Gaps = 35/313 (11%) Query: 14 QDILLLDGAMATELEARGCNLADS-LWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 +LLDG + EL RG + LWSA L E P+L++EVH +Y RAGA T +Y Sbjct: 10 GGPVLLDGGLGQELIRRGMPSTEPSLWSANALTEAPDLVQEVHEEYLRAGADVITTNTYA 69 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 P + GL + +++AL ++ LA +AR A L+AGS+ P Sbjct: 70 TPPERLSEAGL-DGRAEALNREAGRLAERARAAV------GRDALIAGSLPPI------R 116 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 YR D + +R + L DL CET+ E A A + Sbjct: 117 GSYRPDLVGEAGEIEPQYREQA-GYLAPHVDLFLCETMSTPGEARAAARGAAS-TGLPVL 174 Query: 193 FSFTLRD-------SEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL 245 S+T+ D L +G L + V L+G P V + +NC E+ +AA+ L L Sbjct: 175 VSYTIADPSSPEDAEPRLHNGESLEEAVEALSGLP-VAGVLLNCSHPESISAAVPVLRQL 233 Query: 246 TVLPLVVYPNSGEHY-----------DAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGG 294 T + Y N+ H D+ ++ ++ W +AGA ++GG Sbjct: 234 TDRAVGAYANAFTHIPDGFDERADALDSDARPDRREDLAPEAYGRHVEDWLSAGANIVGG 293 Query: 295 CCRTTPADIAALK 307 CC P IA L+ Sbjct: 294 CCEVGPGHIAHLR 306 >UniRef50_C4Z117 Methylenetetrahydrofolate reductase n=1 Tax=Eubacterium eligens ATCC 27750 RepID=C4Z117_EUBE2 Length = 595 Score = 227 bits (579), Expect = 4e-58, Method: Composition-based stats. Identities = 60/299 (20%), Positives = 104/299 (34%), Gaps = 28/299 (9%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K +IL+ DGA T ++ + + +H +Y AGA+ T ++ Sbjct: 15 KSEILVADGAFGTYYAK---KYDTGSLPELANLQASDRVLAIHKEYIEAGAKIIRTNTFA 71 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 + G + + I +V++AR+A + +LVA +GP Sbjct: 72 SNTVCL---GAGFDEVRNNIKNAVDIAREAVK--------GTDVLVAADIGPI------- 113 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 G+ E + + V + G D+ ET P I+ E Sbjct: 114 ---PGENMIEKEHIEKEYVDIVNVFKECGVDIFVFETFPELGFIDKAIENAGENG--FVI 168 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLV 251 F + + S G R ++ + A G NC + + +Q L Sbjct: 169 TQFAINQFGYSSAGFSARKLIEEAGKNSYIDACGFNCGVGPGHMKKLVQSLINRNDKYFA 228 Query: 252 VYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKARS 310 V PN+G + + A + + GA +IGGCC TTP I + ++ Sbjct: 229 VLPNAGYPQVVSGRMVF-DDNNAAYFSQIMHDLAEDGADIIGGCCGTTPEYIRQMVLKT 286 >UniRef50_Q08985 Homocysteine S-methyltransferase 2 n=17 Tax=Saccharomycetaceae RepID=SAM4_YEAST Length = 325 Score = 227 bits (578), Expect = 5e-58, Method: Composition-based stats. Identities = 87/324 (26%), Positives = 153/324 (47%), Gaps = 34/324 (10%) Query: 6 PLRALL--DKQDILLLDGAMATELEARGCNLADSLWSAKVLVE----------NPELIRE 53 PL+ L + + +L+LDG TELE RG +A+ +WS + N ++++E Sbjct: 5 PLKQFLADNPKKVLVLDGGQGTELENRGIKVANPVWSTIPFISESFWSDESSANRKIVKE 64 Query: 54 VHLDYYRAGAQCAITASYQATPAGFAARG--LDEAQSKALIGKSVELARKAREAYLAENP 111 + D+ AGA+ +T +YQ + + ++ L+ + V+ +R Sbjct: 65 MFNDFLNAGAEILMTTTYQTSYKSVSENTPIRTLSEYNNLLNRIVDFSRNCI-------- 116 Query: 112 QAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVE--AFQAFHRPRVEALLDA-GADLLACE 168 + G +GP+GA++ E+ GDY E F + +P++E DL+ E Sbjct: 117 -GEDKYLIGCIGPWGAHICR--EFTGDYGAEPENIDFYQYFKPQLENFNKNDKLDLIGFE 173 Query: 169 TLPNFSEIEALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGY-----PQVV 223 T+PN E++A+ + + ++ + L DGT + ++ ++ P Sbjct: 174 TIPNIHELKAILSWDESILSRPFYIGLSVHEHGVLRDGTTMEEIAQVIKDLGDKINPNFS 233 Query: 224 ALGINCIALENTTAALQHLHGL-TVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLP 282 LGINC++ + L+ LH + L+ YPNSGE YD K W + + + Sbjct: 234 FLGINCVSFNQSPDILESLHQALPNMALLAYPNSGEVYDTEKKIWLPNSDKLNSWDTVVK 293 Query: 283 QWQAAGARLIGGCCRTTPADIAAL 306 Q+ ++GAR+IGGCCRT+P DI + Sbjct: 294 QYISSGARIIGGCCRTSPKDIQEI 317 >UniRef50_Q2RU64 Methionine synthase (B12-dependent) n=10 Tax=cellular organisms RepID=Q2RU64_RHORT Length = 1182 Score = 226 bits (577), Expect = 7e-58, Method: Composition-based stats. Identities = 69/314 (21%), Positives = 128/314 (40%), Gaps = 29/314 (9%) Query: 7 LRALLD--KQDILLLDGAMATELEAR-----GCNLADSLWSAKVLVENPELIREVHLDYY 59 + LD + +LL DG M + ++A G + + + + P+++R++H Y+ Sbjct: 1 MSRFLDHLRNRVLLCDGGMGSLVQAMDLSVDGDFMGRENCTEVLNLSRPDVVRDIHTRYF 60 Query: 60 RAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVA 119 AGA C T ++ + A L + +++ + ++ E+ V Sbjct: 61 AAGADCVETNTFGGSTLTLAEFDLAD-RTREINRRAAEI----AREAAESFADGRDRFVL 115 Query: 120 GSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEAL 179 GS+GP G++ H + + + E L++ GAD + ET + + +A Sbjct: 116 GSIGP-------GTKLPSLGHIDYDTLKDAITVQCEGLIEGGADAILVETCQDPLQFKAA 168 Query: 180 AEL-----LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALE 233 L T+ + L G + + V +LG+NC + Sbjct: 169 INAAKAARLALGSDTAILLQVTVETTGTLLVGADIAAAATVAHAL-GVDSLGLNCATGPQ 227 Query: 234 NTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW-QAAGARLI 292 + ++ L + + PN+G KT H+ A+LAD+ ++ + G LI Sbjct: 228 EMSEHVRWLKENWPGLISLQPNAGLPELLDGKT--HYPLTPAELADWHGRFIREDGVNLI 285 Query: 293 GGCCRTTPADIAAL 306 GGCC TTP IAA+ Sbjct: 286 GGCCGTTPDHIAAV 299 >UniRef50_B5JEM8 Homocysteine S-methyltransferase, putative n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JEM8_9BACT Length = 318 Score = 226 bits (576), Expect = 8e-58, Method: Composition-based stats. Identities = 63/315 (20%), Positives = 111/315 (35%), Gaps = 29/315 (9%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 + L L ++ +L+ DGAM T+L A G S + +P+ + + Y +G Sbjct: 18 MSKTLIETL-REKVLVSDGAMGTQLMAAGLEAGGSG--EMWNLTHPDRVLAIQKRYVDSG 74 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 + C IT ++ G + Q + +V++AR A V Sbjct: 75 SNCIITNTFGGNGLMLRRHGHFD-QLAEINQAAVKIARDAFGGGEGFVFG--------DV 125 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G + + + R +++AL++AGAD + ET + +EI E Sbjct: 126 GPVGGVMEPYGDLKP------ADVAEGVRIQIQALVEAGADAIIIETQTDLNEIALGIEA 179 Query: 183 LTAYPRARAWFSFTLRDSE-----HLSDGTPLRDVVALLAGYPQVVALGINCIALENTT- 236 Y S S G L V L +NC + T Sbjct: 180 AKKYGAPCIIASLAYDKSHDGSFFRTMMGISPEKAAEELTDL-GVDILALNCGTGIDMTV 238 Query: 237 --AALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGG 294 ++ + + PN+G K + + ++ L G ++GG Sbjct: 239 AREIIEEYKDNSDAFTMAQPNAGLPVLENMKAV--YKQTPTEMVSTLDALLEEGVNIVGG 296 Query: 295 CCRTTPADIAALKAR 309 CC + P I A++ + Sbjct: 297 CCGSNPDHIRAIREK 311 >UniRef50_A8TIL6 Methionine synthase I n=3 Tax=Proteobacteria RepID=A8TIL6_9PROT Length = 344 Score = 225 bits (575), Expect = 1e-57, Method: Composition-based stats. Identities = 73/309 (23%), Positives = 114/309 (36%), Gaps = 17/309 (5%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 + L LL ++ L+ DGAM T L A G DS VE+P+ + VH D+ AG Sbjct: 1 MADCLTDLLAERGHLIADGAMGTNLFALGLETGDS--PELWNVEHPDRVATVHRDFLEAG 58 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 + +T S+ + + + + L + +AR+ +A+ A LVAGS+ Sbjct: 59 SDIVLTNSFGGSSFRLKLHH-AQDRVRELNAAAAGIARREVDAHAA--STGRRTLVAGSI 115 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G + A QA L + GAD+L ET+ E+ A Sbjct: 116 GPTGELFIPLGALTAEAAADAFAEQA------AGLAEGGADVLWIETMSAPEEVLAAV-A 168 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYP-QVVALGINC-IAL-ENTTAAL 239 A + T + G + VA+G NC + E L Sbjct: 169 GGARTGLPIVVTMTFDTNARTMMGVTPVEFANFAQALEHTPVAIGANCGVGPAELVDTIL 228 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 ++ N G + +A Y + AGAR++GGCC +T Sbjct: 229 GITAAAPGAVVIAKGNCGIPQYVEGAIV--YNGSPEAMAAYAQLVRDAGARIVGGCCGST 286 Query: 300 PADIAALKA 308 + A+ Sbjct: 287 AIHVKAIAE 295 >UniRef50_Q6C0D6 YALI0F25641p n=1 Tax=Yarrowia lipolytica RepID=Q6C0D6_YARLI Length = 348 Score = 224 bits (571), Expect = 3e-57, Method: Composition-based stats. Identities = 115/347 (33%), Positives = 165/347 (47%), Gaps = 58/347 (16%) Query: 16 ILLLDGAMATELEARGCNLADSLW----SAKVLV-------------------------- 45 +L+LDG M TELE RG + +D LW SAK L+ Sbjct: 1 MLILDGGMGTELENRGIDCSDPLWLTLWSAKFLLPINSDFLKCIESADPWTVDQLEKVNR 60 Query: 46 ---ENPE----------LIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALI 92 E+PE L+ +H DY AGA +ASYQA+ G G + +AL Sbjct: 61 ALDEHPEWLESSQDNSNLLYRIHKDYVVAGADIVTSASYQASLEGTIKAGAVQRWPEALW 120 Query: 93 --GKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYRGDY-HCSVEAFQAF 149 KS +L RKA E +L+A SVGP+GA+L G EY GDY + + + Sbjct: 121 MLRKSEQLVRKAV----TEAKVKRKVLLAASVGPFGAWLGGGQEYNGDYTGYTKDDIRRH 176 Query: 150 HRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY---PRARAWFSFTLRDSEH---- 202 H ++ A+L D+L ET+P+ E+E L ++L S +++ +++ Sbjct: 177 HEFKIRAVLGGSPDMLLIETIPSIIEVEVLVDVLNTILPPSPIPVCLSLSVKSADYDRVA 236 Query: 203 LSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYPNSGEHYDA 262 L+DG+ L ++ L A P LG+NC A +L L T L L+VYPNSGE YD Sbjct: 237 LADGSELSNIAELAASCPSFTHLGVNCCAETVAKLSLDILQQHTSLQLIVYPNSGEVYDG 296 Query: 263 VSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKAR 309 +KTW + + A L WQ + ++GGCCRT P IA L+ + Sbjct: 297 ATKTWSGNCDSSFLEAATLSDWQTS-VSILGGCCRTGPPHIAFLRHK 342 >UniRef50_D1BTI0 Methionine synthase n=24 Tax=Actinomycetales RepID=D1BTI0_XYLCX Length = 1193 Score = 223 bits (569), Expect = 6e-57, Method: Composition-based stats. Identities = 61/306 (19%), Positives = 116/306 (37%), Gaps = 27/306 (8%) Query: 13 KQDILLLDGAMATELEARGCNLAD----SLWSAKVLVENPELIREVHLDYYRAGAQCAIT 68 + +++ DGAM T ++ + L D + + V P++I VH Y AG T Sbjct: 26 RSRVVVADGAMGTMIQEQDPTLEDYEGHEGCNEVLNVSRPDIIGAVHDAYLEAGVDAIET 85 Query: 69 ASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 ++ A + G+ + + + L +AR +A+ V GS+GP Sbjct: 86 NTFGANWSNLGDYGI-DHRIRELARAGAAIARSRADAFATP---DRPRWVLGSMGP---- 137 Query: 129 LADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL-----L 183 G++ H + ++ + LL+ GAD L ET + + +A Sbjct: 138 ---GTKLPSLGHTTYAHLRSTFAEQAAGLLEGGADALLIETSQDLLQAKAAVTAAHDAFA 194 Query: 184 TAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHL 242 R S T+ + + G+ + + L V +G+NC + + L++L Sbjct: 195 AVGRRVPVMVSVTVETTGTMLMGSEIGAALTALQAI-GVDTIGLNCATGPDKMSEHLRYL 253 Query: 243 HGLTVLPLVVYPNSGEHYDAVSKTWHHHGEH--CAQLADYLPQWQAAGARLIGGCCRTTP 300 + +P+ PN+G + A A ++ ++ G TTP Sbjct: 254 SQHSEMPVTSMPNAGLPELGPHGAVYPLSATELAAAHAQFVREFGLGLVGGCCG---TTP 310 Query: 301 ADIAAL 306 +AA+ Sbjct: 311 EHLAAV 316 >UniRef50_A4EKV4 Methionine synthase I n=4 Tax=Alphaproteobacteria RepID=A4EKV4_9RHOB Length = 339 Score = 222 bits (567), Expect = 1e-56, Method: Composition-based stats. Identities = 77/309 (24%), Positives = 114/309 (36%), Gaps = 21/309 (6%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 N L LL +D L+ DGA T L G D+ V+ I ++ AG Sbjct: 2 MTNALSNLLKTRDWLMADGATGTNLFNMGLMSGDA--PEMWNVDETAKIIALYKGAADAG 59 Query: 63 AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSV 122 + +T S+ A + G E + K L + EL R+ + ++VAGSV Sbjct: 60 SDIFLTNSFGANASRLKLHG-AEGRVKELNKAAAELGREVAD------ASERVIVVAGSV 112 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G +A + E + E L GAD+L ET+ A A Sbjct: 113 GPTGEIMAPMGS------LTHEIAVEMFHEQAEGLKAGGADVLWVETISAPE-EFAAASE 165 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYP-QVVALGINCI--ALENTTAAL 239 A + + + G D+V + Q G NC A + L Sbjct: 166 AFALADMPWCGTMSFDTAGRTMMGLTSADMVKKVGKLAHQPFGFGANCGVGASDLLRTVL 225 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 LP++ N+G H+ A +ADY + GA +IGGCC TT Sbjct: 226 GFAAADPTLPIIAKGNAGIPKYHDGH--IHYDGTPALMADYAVLARDCGATIIGGCCGTT 283 Query: 300 PADIAALKA 308 P + A++ Sbjct: 284 PEHLRAMRE 292 >UniRef50_Q753B4 AFR410Wp n=1 Tax=Eremothecium gossypii RepID=Q753B4_ASHGO Length = 370 Score = 222 bits (566), Expect = 1e-56, Method: Composition-based stats. Identities = 86/325 (26%), Positives = 138/325 (42%), Gaps = 22/325 (6%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVE----NPELIREVHL 56 M+ + L++ +L++DG M ELE RG ++ LWS + + IR ++ Sbjct: 45 MAAKCAITEFLERN-VLVMDGGMGVELERRGMDVKSPLWSTAPFLRGDRAALDTIRGLYR 103 Query: 57 DYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTL 116 ++ AG++ T +YQA+ + + + + E Sbjct: 104 EFRAAGSRGISTLTYQASFHSMVKYSGSVSSRADY----EKFLEQVVDFTYRECVDPARD 159 Query: 117 LVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALL-DAGADLLACETLPNFSE 175 + GSVGPY A+L +G+EY GDY F + P+V D D +A ET+PN E Sbjct: 160 YIIGSVGPYAAFLCNGAEYTGDYGFETINFFNYFEPQVSKFATDPRIDAIAFETVPNVVE 219 Query: 176 IEALA--ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGY-----PQVVALGIN 228 + A+ E + S + +D L DGTPL V L+ P ++ G+N Sbjct: 220 LMAMLQPEFHALLKNKPFYISISAKDEHVLRDGTPLAVVGQLIRERMDDLPPNLLCFGLN 279 Query: 229 CIALENTTAALQHLH-GLTVLPL---VVYPNSGEHYDAVSKTWHH-HGEHCAQLADYLPQ 283 C+ L + A L L+ L P+ +YPN +D W A+ + Sbjct: 280 CVDLTRSAAMLAELNMQLQDCPIKFQAIYPNGTSVFDESLSAWRPSKDAESLTWAEAVKL 339 Query: 284 WQAAGARLIGGCCRTTPADIAALKA 308 + R+IGGCC TTP D+ + Sbjct: 340 YLNQDCRMIGGCCGTTPQDMRQIAE 364 >UniRef50_A5DTG6 Putative uncharacterized protein n=1 Tax=Lodderomyces elongisporus RepID=A5DTG6_LODEL Length = 326 Score = 221 bits (563), Expect = 3e-56, Method: Composition-based stats. Identities = 106/329 (32%), Positives = 159/329 (48%), Gaps = 33/329 (10%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEAR------GCNLADSLWSAKVLVENPELIREV 54 MSQN + +K+ ++LDGA+ T LE LWS +VL++ PELI++V Sbjct: 1 MSQN-----IFNKK--VVLDGALGTALEDLIDPSAPYLPSKSPLWSGQVLLDAPELIQKV 53 Query: 55 HLDYYRAGAQCAITASYQATPAGFAAR-GLDEAQSKALIGKSVELARKAR------EAYL 107 H Y AG++ T++YQ + L + Q + +S++L R A Y Sbjct: 54 HEMYIGAGSEVIFTSTYQLSYDSLRKHTTLSDEQILEVWQRSIDLVRAAALSIDETARYT 113 Query: 108 AENPQA---GTLLVAGSVGPYGAYLADGSEYRGDYH-CSVEAFQAFHRPRVEALLDAG-A 162 E G + +AGS+GPY AYLA+GSEY GDY + E +AFH P +E + Sbjct: 114 KEKESRGEPGKVHIAGSIGPYAAYLANGSEYTGDYGNVTDEQLEAFHTPMLEFFTENEAV 173 Query: 163 DLLACETLPNFSEIEALAELLTAY-PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGY-- 219 DL+A ET+PNF E++A+ +L+ + FS T ++ ++L+DGTPL +V L Sbjct: 174 DLIAFETIPNFQELKAVTKLVKRLNCKKPVLFSITCQNLDNLTDGTPLLEVKKYLDFCLP 233 Query: 220 PQVVALGINCIALENTTAALQHLHGLTVLPLVVYPNSGEHYD-AVSKTWHHHGEHCAQLA 278 + LGINC+ + H G VYPN G YD + G Sbjct: 234 KEQKILGINCVEYTLVQGIMSHFAGFK---FYVYPNLGFEYDLEKHQFVIKEGRSEDDWR 290 Query: 279 DYLPQWQAAGARL-IGGCCRTTPADIAAL 306 ++ + A + IGGCC T +I + Sbjct: 291 LFVENLASKEAVIGIGGCCNTGVKEIEQI 319 >UniRef50_B7I892 Homocysteine S-methyltransferase family protein n=12 Tax=Proteobacteria RepID=B7I892_ACIB5 Length = 313 Score = 221 bits (563), Expect = 3e-56, Method: Composition-based stats. Identities = 80/301 (26%), Positives = 113/301 (37%), Gaps = 29/301 (9%) Query: 18 LLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATPAG 77 +LDG + EL RG WSA L+E PE ++EVHLD+ AGA+ T +Y P Sbjct: 24 ILDGGLGRELARRGAPFRQPEWSALALIEAPETVKEVHLDFINAGAEVITTNNYAVVPFH 83 Query: 78 FAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEYRG 137 + + LI ++E A+ A + + +AG + P YR Sbjct: 84 IGQERFETDGVR-LIKVAIEQAKNAVKE------SGKNVKIAGCLPPL------FGSYRA 130 Query: 138 DYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSFTL 197 D E + P + L D ET E+E + LL W SFTL Sbjct: 131 DLFQ-PEQAKNLAEPIINTLA-PEVDFWLAETQSCLKEVETVHALLPQ-DGKDYWVSFTL 187 Query: 198 RDSEH-----LSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL--TVLPL 250 +D L G ++ V + A+ NC E A+ + GL + + Sbjct: 188 QDEIKQEQALLRSGENMQQVADFIKQ-SNAKAVLFNCCQPEVILQAINEIKGLIPESVQI 246 Query: 251 VVYPNSGEHYDA-----VSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAA 305 Y N+ D + QWQ AGA L+GGCC P IA Sbjct: 247 GAYANAFPPQDESATANDGLDEIRKDLDAPAYLGFAKQWQQAGASLVGGCCGIGPEHIAE 306 Query: 306 L 306 L Sbjct: 307 L 307 >UniRef50_C5E3E4 KLTH0H12716p n=1 Tax=Lachancea thermotolerans CBS 6340 RepID=C5E3E4_LACTC Length = 348 Score = 220 bits (561), Expect = 4e-56, Method: Composition-based stats. Identities = 83/327 (25%), Positives = 134/327 (40%), Gaps = 27/327 (8%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLV----ENPELIREVHLDY 58 PL+ K +ILLLDG TELE +G +++ LWS + + E I+E++ D+ Sbjct: 1 MRKPLKEFF-KNNILLLDGGQGTELEKKGVSISHPLWSTLPFIIKNKTHLEAIKEMYRDF 59 Query: 59 YRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLV 118 AG+ +T +YQA+ + S+ ++ + + Sbjct: 60 AEAGSNALMTITYQASFSSMKKYSEGLVNSEEDYAAFLDY----VIGFTDRECITPDKYL 115 Query: 119 AGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEAL-LDAGADLLACETLPNFSEIE 177 GSVGPY L++G+EY G Y F ++ P+V+ L DL+ ET+PN E + Sbjct: 116 VGSVGPYAGLLSNGAEYSGYYGEGKIDFIDYYSPQVKHFALSPRIDLIGIETIPNIDEFK 175 Query: 178 ALA--ELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYP-----QVVALGINCI 230 AL E + S T ++ L DGT L ++ + V INC+ Sbjct: 176 ALLSPEFSRLSFSKPYYISVTTDNNGCLRDGTSLNEICRAIKQSASLLPDNFVFFAINCV 235 Query: 231 ALENTTAALQHLHGLTVLPL--------VVYPNSGEHYDAVSKTWH--HHGEHCAQLADY 280 + LQ L+ + YPNSGE Y + +W + + Sbjct: 236 EFLHCVEILQSLNDCLEMQGVDRRFRFRGAYPNSGEIYHGGTHSWSSNPYAGPEDTWENL 295 Query: 281 LPQWQAAGARLIGGCCRTTPADIAALK 307 + ++GGCCRT +I + Sbjct: 296 TLGLLSQECLMLGGCCRTGSEEIRQMA 322 >UniRef50_A8M0Q1 Homocysteine S-methyltransferase n=3 Tax=Actinomycetales RepID=A8M0Q1_SALAI Length = 307 Score = 220 bits (561), Expect = 4e-56, Method: Composition-based stats. Identities = 82/302 (27%), Positives = 117/302 (38%), Gaps = 23/302 (7%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVEN--PELIREVHLDYYRAGAQCAITASYQ 72 L+LDG + TEL+ RG ++ W+A L + LI ++H +Y AGA +++ Sbjct: 8 RPLILDGGLGTELQRRGRSVTAPWWTAHCLRDADGRRLIAQIHAEYVTAGADVITADTFR 67 Query: 73 ATPAGFAARGLD-EAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLAD 131 TP G+ + L+ +V LAR+A + +LVAGSV P Sbjct: 68 TTPRAAHRAGIAGHTVAADLVRTAVALAREAADTV------RRRVLVAGSVAPV------ 115 Query: 132 GSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARA 191 YR D + + H E L DL+ ET+ E A + A A Sbjct: 116 EDCYRPDLVPNDGVLRREHAWLAEQLARTSVDLVLVETMNTAREAVAATRAVCA-EGLPA 174 Query: 192 WFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLV 251 W SF + L GT + A + +NC T AL+ L V PL Sbjct: 175 WVSFVCTNDARLLSGTDVVAA-AAAVRAAGADMVLVNCTDPAGTDGALRRLRRPDVGPLG 233 Query: 252 VYPNS----GEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 YPN G A + A+ W +GGCC +TP IA L+ Sbjct: 234 AYPNLEDRRGLPPAAAVDRYLPPRLTPDAFAELCAGWYYLDV--VGGCCGSTPTHIATLR 291 Query: 308 AR 309 R Sbjct: 292 GR 293 >UniRef50_A3LQC9 AdoMet-homocysteine methyltransferase n=1 Tax=Pichia stipitis RepID=A3LQC9_PICST Length = 337 Score = 220 bits (561), Expect = 5e-56, Method: Composition-based stats. Identities = 98/334 (29%), Positives = 158/334 (47%), Gaps = 34/334 (10%) Query: 6 PLRALLDKQDILLLDGAMATELEA------RGCNLADSLWSAKVLVENPELIREVHLDYY 59 L+ L K L+LDGAM TELEA + LWS VL+ P LI+ VH +Y Sbjct: 3 SLKEALSKNR-LVLDGAMGTELEACIPKDSKIQPRKHPLWSGLVLLNEPNLIKNVHYNYL 61 Query: 60 R-AGAQCAITASYQATPAGFAAR-GLDEAQSKALIGKSVELARKAREAYLAENP-QAGTL 116 A I+++YQ + LD+ Q + + KS+++ A Y ++N + Sbjct: 62 EQADVDALISSTYQISYPSLKEHTDLDDEQIRGIWKKSIDVVEDAILQYRSKNSNSKKKI 121 Query: 117 LVAGSVGPYGAYLADGSEYRGDY-HCSVEAFQAFHRPRVEALL-DAGADLLACETLPNFS 174 + GS+GPY YLADGSEY GDY + S +++H+P +E L D D + ET+P+F Sbjct: 122 YIIGSIGPYATYLADGSEYTGDYKNASDSDIESYHQPLLEYFLGDDRVDTIGFETIPSFQ 181 Query: 175 EIEALAEL-----LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQ-------- 221 E++ + +L R + SF D ++DGTP V++ + + Sbjct: 182 EVKVVLKLLSHLFAEQEKRKYYYISFNF-DEATITDGTPTEVVISYIDSFLDKYPFLRKY 240 Query: 222 VVALGINCIALENTTAALQHLHGLTV------LPLVVYPNSGEHYDAVSKTWHHHGEHCA 275 +V LG+NCI + + ++ PL+VYPN Y + + + Sbjct: 241 MVGLGLNCIDYHKIGSIVAKINDSQTSAQKPLFPLIVYPNFTIKYVPEEDDYRAY-KDIE 299 Query: 276 QLADYLPQWQA-AGARLIGGCCRTTPADIAALKA 308 + + + +W R+IGGCC T+P +I ++ Sbjct: 300 KWKELVSEWVTIPNVRMIGGCCSTSPKEIKEVRR 333 >UniRef50_A4J5C2 Methylenetetrahydrofolate reductase n=5 Tax=Clostridiales RepID=A4J5C2_DESRM Length = 598 Score = 220 bits (561), Expect = 5e-56, Method: Composition-based stats. Identities = 57/304 (18%), Positives = 116/304 (38%), Gaps = 26/304 (8%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 +R L K +IL+ DGAM T ++ + PE+I +H +Y AGA+ Sbjct: 2 IREYL-KNNILITDGAMGTYYAQITGKYN--VFPEFANINEPEIIERIHTEYINAGAKLI 58 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 T ++ A + +++ K ++ ++LA K + ++ +A S+GP Sbjct: 59 KTNTFSANSRVLK---IPKSEVKKIVLAGLDLANKVAQ--------GKSIFIAASIGPIP 107 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 E E ++ V+ L++ + ET + S++ + + + Sbjct: 108 -------EMFDKMETDQENSLDEYKFIVDIFLNSDIKIFMFETFSDVSDLLEITKYIKVK 160 Query: 187 PRARAWFS-FTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHG 244 + + F G + ++A + + A G NC + + +L+ L Sbjct: 161 DSSAFIVTQFATTPEGFTRKGLSNKHIIAEVKKSKSIDAYGFNCGVGPTHLFNSLKKL-N 219 Query: 245 LTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 + PN+G + ++ A+ + G +++GGCC TTP I Sbjct: 220 FADDMVAAAPNAGYPEIV--HERMVYIQNPNYFAEKMKDISGLGVKILGGCCGTTPIHIE 277 Query: 305 ALKA 308 + Sbjct: 278 KMSE 281 >UniRef50_UPI0001BCEC92 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein n=1 Tax=Selenomonas noxia ATCC 43541 RepID=UPI0001BCEC92 Length = 597 Score = 219 bits (559), Expect = 9e-56, Method: Composition-based stats. Identities = 75/309 (24%), Positives = 117/309 (37%), Gaps = 29/309 (9%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M+QN+ K++ L+ DG M T + + +E P ++ +H +Y + Sbjct: 1 MAQNSADIREHIKKEPLVFDGGMGTYYAQKTHTHGKGV--ELANIETPAVVGAIHTEYLQ 58 Query: 61 AGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 AGAQ T ++ A DE+ + +I E+A +A E + A V Sbjct: 59 AGAQAIKTNTFAANRIV---YQGDESLVRRIIRAGWEIAARAAEPFGA--------YVFA 107 Query: 121 SVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEI-EAL 179 +GP A +R + L GA ET + + E Sbjct: 108 DIGPVT-------------GLPHTDIIAEYRFLADTFLACGATHFLFETNASIEGLIETA 154 Query: 180 AELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAAL 239 A + P A SF+ + DG D++ A + A+G NC+ L Sbjct: 155 AHIKRICPHAFILASFSALPGGYTRDGRFAEDLIHEAAESGSIDAVGFNCVNGVRQMREL 214 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 H G+T LPL + PN+G +T++ L G ++GGCC TT Sbjct: 215 GHHLGMTSLPLSLMPNAGHPIVVDGRTFYESA--PEYFGTSLAAIVRDGISIVGGCCGTT 272 Query: 300 PADIAALKA 308 P I AL A Sbjct: 273 PEHIRALCA 281 >UniRef50_A7VPD0 Methylenetetrahydrofolate reductase n=1 Tax=Clostridium leptum DSM 753 RepID=A7VPD0_9CLOT Length = 600 Score = 219 bits (558), Expect = 1e-55, Method: Composition-based stats. Identities = 67/310 (21%), Positives = 113/310 (36%), Gaps = 36/310 (11%) Query: 7 LRALLDKQDILLLDGAMATEL-EARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQC 65 L LL ++ ++ DGAM T + G ++ + W + PELI E+H +Y +AGAQ Sbjct: 3 LDTLLKQKRPVITDGAMGTYFTQKTGFSIHECEW---ANISRPELISEIHREYVKAGAQF 59 Query: 66 AITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY 125 T ++ A G A ++ LA++A + Sbjct: 60 LRTNTFSANTKSL---GRPLADVLEIVRAGYRLAKEAAGCQAVAAADMTAIY-------- 108 Query: 126 GAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA 185 + +A L GA++ ETL S + +A+ L Sbjct: 109 ------------PRGDEETDLLPEYLAIADAFLSEGAEVFLFETLTELSPFDQIADYLKK 156 Query: 186 Y-PRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQ-VVALGINC-IALENTTAALQHL 242 P + SFT+ G PLR ++ + + + +G+NC + + L Sbjct: 157 KKPECKVLISFTVSPEGITRLGVPLRRLLDEVKPHRELFDGIGLNCGCGPAHILKFAREL 216 Query: 243 ----HGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRT 298 LP++V PN+G ++T + + G +IGGCC T Sbjct: 217 LSYSRQYLSLPVLVMPNAGYPAMEENRTV--FDTSPEYFSHQAVRIAELGVDMIGGCCGT 274 Query: 299 TPADIAALKA 308 TP + L Sbjct: 275 TPKHLQLLSR 284 >UniRef50_B4DBI1 Homocysteine S-methyltransferase n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4DBI1_9BACT Length = 283 Score = 219 bits (557), Expect = 2e-55, Method: Composition-based stats. Identities = 72/296 (24%), Positives = 111/296 (37%), Gaps = 29/296 (9%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 + +L+ DGAM TEL A G L ++ V +P+L+R VH Y AGA+ T ++ Sbjct: 8 QHRVLIGDGAMGTELLAHGVPPGRCL--EELCVSDPDLVRGVHERYIAAGARLIETNTFG 65 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A A G E + L + +LA+ + + VAG VGP G + Sbjct: 66 ANAVRLAQYGC-EHRVGELNWTAAQLAKDVA--------RGKDVYVAGCVGPLGITAEEA 116 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 + D H ++ ALLD G ++ ET + E+ E A Sbjct: 117 AARGIDRH-------EVFTDQIGALLDGGCRIIFLETFLDADELLVALEAKQALHHCPVV 169 Query: 193 FSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVV 252 T D + +A + + +G NC+ + L + L Sbjct: 170 AMLTSNDR------QAFQAAIAKVRA-AEAEVVGANCVDGTHALHLLDGMDPDAT--LAA 220 Query: 253 YPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 +P++G + + A G RL+GGCC P IAAL A Sbjct: 221 FPSAGLPKTHDQQL--AYPTTPEVFAANARTLAERGVRLLGGCCGVGPQHIAALAA 274 >UniRef50_C6UN88 Putative B12-dependent methionine synthase n=1 Tax=Candidatus Hodgkinia cicadicola Dsem RepID=C6UN88_HODCD Length = 1185 Score = 217 bits (552), Expect = 5e-55, Method: Composition-based stats. Identities = 71/322 (22%), Positives = 127/322 (39%), Gaps = 27/322 (8%) Query: 4 NNPLRAL--LDKQDILLLDGAMATELEARGCNLAD------SLWSAKVLVENPELIREVH 55 ++ L+AL + + L+LDGAM T+++ + + + + P+++ VH Sbjct: 9 SSALKALTAISSKRALVLDGAMGTQIQKFKLKPKHYGVEASNGNNDALNMTQPKVVEGVH 68 Query: 56 LDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGT 115 Y AG+ T ++ + A G + L + +AR+A QA Sbjct: 69 AAYAAAGSDVLSTNTFCSCSVSQADYGTPYS-CSDLNARGCLIARRACLKAG--FAQARR 125 Query: 116 LLVAGSVGPYG--AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNF 173 + VAG +GP A + + + + +R + +ALL +GAD L ET+ + Sbjct: 126 VFVAGVLGPTNKSASIPADASRPSHRDVTFDDLVLSYRQQADALLASGADALLVETVFDT 185 Query: 174 SEIEALAELLTAYP-----RARAWFSFTLRD-SEHLSDGTPLRDVVALLAGYPQVVALGI 227 +A + R S T+ D S G + + + + + +G+ Sbjct: 186 LNAKAGLKACIDASASYRKRRALVASATISDASGRTLSGQTI-EAFWVSVKHANLAGVGL 244 Query: 228 NCI-ALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQA 286 NC + L P+ VYPN+G + + + A L + Sbjct: 245 NCALGPAQLSRHAAALALAAEAPIWVYPNAGLPNEMG-----KYTQGAKAFAHALKRCFG 299 Query: 287 AGARLIGGCCRTTPADIAALKA 308 A +GGCC +TP I+ LKA Sbjct: 300 V-ASAVGGCCGSTPEHISELKA 320 >UniRef50_Q28RZ7 Homocysteine S-methyltransferase n=13 Tax=Rhodobacteraceae RepID=Q28RZ7_JANSC Length = 297 Score = 216 bits (550), Expect = 1e-54, Method: Composition-based stats. Identities = 94/305 (30%), Positives = 133/305 (43%), Gaps = 30/305 (9%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 +I +LDG M EL +R LWS V+ P L+ EVH D++ AGAQ A +Y Sbjct: 3 EITILDGGMGQELVSRSDVPPTPLWSTDVMRAKPHLVGEVHRDFFNAGAQIATANTYAIH 62 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 EA+ +L +++ AR+AR+A+ + LVAG++GP GA Sbjct: 63 RDRLVRAD-AEAEFASLHKTALDQARQARDAHGS-------GLVAGAIGPLGA------S 108 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 YR D A A + + L DLL CET+ + ++ EA+ + W + Sbjct: 109 YRPDLTPQHSAAVALYAE-IATLHAPLVDLLICETITSLAQAEAVLDACL-GHGVPVWLA 166 Query: 195 FTLR--DSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVV 252 F++ D L G L DV+A+ + AL NC E AAL L G P Sbjct: 167 FSVDDRDGTRLRSGEGLGDVIAMA---GEAAALLANCSVPEVMPAALDIL-GRAGTPFGA 222 Query: 253 YPN------SGEHYDA--VSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 Y N +G DA V AD++ W GA ++GGCC PA IA Sbjct: 223 YANGFTEISAGFLDDAPTVDALTSRTDMGPEAYADHVMGWIDQGATIVGGCCEVGPAHIA 282 Query: 305 ALKAR 309 + R Sbjct: 283 EITRR 287 >UniRef50_A5N923 Methylenetetrahydrofolate reductase n=2 Tax=Clostridium kluyveri RepID=A5N923_CLOK5 Length = 590 Score = 215 bits (549), Expect = 1e-54, Method: Composition-based stats. Identities = 56/295 (18%), Positives = 104/295 (35%), Gaps = 31/295 (10%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 K+ L+ DGAM T + + + I ++H +Y AG T ++ Sbjct: 4 KEKPLIFDGAMGTYYPRISKDPL-PKC-ELANIYDRNTILKIHREYIEAGCMAIKTNTFG 61 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A + D + K +I E+A++A + +LV +GP + Sbjct: 62 ANKVSLES---DFNKVKEVIINGYEIAKEAAK--------DTEVLVFADIGPIPFLESM- 109 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT-AYPRARA 191 ++ V+ L+ GA ET + + ++E + P A Sbjct: 110 ------------DLYEGYKEIVDLFLELGAKYFIFETFSSDEYLREISEYIKGKDPEAYI 157 Query: 192 WFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPL 250 F + + G + ++ + P + A G NC + ++ + + Sbjct: 158 LMEFAVSPEGYTRVGKSGKKLIENILKIPTIDACGFNCFSGPYHLLQYIKTF-NIGNETI 216 Query: 251 VVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAA 305 V PNSG ++T+ A + + G ++GGCC TTP I Sbjct: 217 SVMPNSGYPTVIDNRTF--FDNTKEYFAQRMLEIAKQGVSILGGCCGTTPEFIRE 269 >UniRef50_A1WU24 Homocysteine S-methyltransferase n=7 Tax=Proteobacteria RepID=A1WU24_HALHL Length = 305 Score = 214 bits (544), Expect = 4e-54, Method: Composition-based stats. Identities = 85/307 (27%), Positives = 122/307 (39%), Gaps = 24/307 (7%) Query: 12 DKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 ++D++LLDG M EL R LWSA+V+++ P+L+ H D+ +AGA+ +Y Sbjct: 3 QERDVVLLDGGMGQELRRRSSQPVTPLWSAQVMLDEPDLVTAAHRDFIQAGARVITANTY 62 Query: 72 QATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLAD 131 ATP A G E + S+ A + + +AG + P A Sbjct: 63 SATPQRLARDGAPE------LFDSLHAAALDAARQARDASGQQDVRIAGCLPPLVA---- 112 Query: 132 GSEYRGDYHCSVEAFQAFHRPRVEALLDA-GADLLACETLPNFSEIEALAELLTAYPRAR 190 YR D + +R VEA A G DL CET+ + + A Sbjct: 113 --SYRPDVAPNDADCLEGYRRMVEAQAQAQGVDLFICETM-SLAREARAATEAAVESNLP 169 Query: 191 AWFSFTLRDSE--HLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVL 248 W +FT+ D + L G L A + +NC E T A+ L GL + Sbjct: 170 VWVAFTVDDGDGTRLRSGESLIQA-AQAVVAAGAERVLVNCAIPEAVTTAMGELTGL-GV 227 Query: 249 PLVVYPNSG------EHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPAD 302 P Y N+ + V A A++ W GA L+GGCC PA Sbjct: 228 PFGGYANAFTSVAALQPGGTVDVLESRTDLDPAAYAEHALHWVEQGATLVGGCCEVGPAH 287 Query: 303 IAALKAR 309 IA L R Sbjct: 288 IAELAER 294 >UniRef50_B8M2P0 Homocysteine S-methyltransferase, putative n=1 Tax=Talaromyces stipitatus ATCC 10500 RepID=B8M2P0_TALSN Length = 369 Score = 213 bits (543), Expect = 6e-54, Method: Composition-based stats. Identities = 92/354 (25%), Positives = 146/354 (41%), Gaps = 57/354 (16%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNL----ADSLWSAKVLVENPELIREVHLDYYRAG 62 + L++ ILLLDG + T LEA N+ LWS+ +L+++P ++ H + AG Sbjct: 15 ISKLVNTMQILLLDGGLGTTLEASPFNVQFTPEKPLWSSHLLIDSPSTLQAAHHAFCDAG 74 Query: 63 AQCAITASYQATPAGFAARG--LDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAG 120 A +TA+YQ + GF + + ++ L R A + VA Sbjct: 75 ADIILTATYQTSTEGFTRTNSSYTARDAAQYMRSAIPLVRSAV----SSTADDKKRSVAL 130 Query: 121 SVGPYGAYLADGS-EYRGDYHCSVE---AFQAFHRPRVEALLDAG------ADLLACETL 170 S+GPYGA ++ S EY G Y ++ A + +H R++ ++ D +A ETL Sbjct: 131 SLGPYGATMSPVSAEYTGIYPPEMDGENALREWHTQRLKIFTESEDESWDQVDYIAFETL 190 Query: 171 PNFSEIEALAELLTAY------PRARAWFSFTLR----DSEHLSDGTPLRDVVALLAGYP 220 E+ A+ + + W D E + +R V G P Sbjct: 191 RRADEVCAVRGAVCDVVGRDSTSKKPWWICGVFPGEQVDEEEIR--QWVRAAVGNHPGLP 248 Query: 221 QVVALGINCIALENTTAALQHLH--------------GLTVLP-LVVYPNS--GEHYDAV 263 + +G+NC ++ A + + + P LV+YP+ GE YD V Sbjct: 249 RPWGIGLNCTRIDRVEAIVSIMRDEVRRLLDQAQIDEWASSKPWLVLYPDGTKGEKYDPV 308 Query: 264 SKTWHHHGEH------CAQLADYLPQW--QAAGARLIGGCCRTTPADIAALKAR 309 +KTW D + G ++GGCCR PADIAAL+ R Sbjct: 309 TKTWVQSVTDTVKRPWDEIFWDIIQHQSKAEWGGIVVGGCCRAGPADIAALRRR 362 >UniRef50_B6BT42 Homocysteine S-methyltransferase 4, putative n=1 Tax=Candidatus Pelagibacter sp. HTCC7211 RepID=B6BT42_9RICK Length = 305 Score = 213 bits (542), Expect = 7e-54, Method: Composition-based stats. Identities = 69/315 (21%), Positives = 123/315 (39%), Gaps = 34/315 (10%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCA 66 ++ LDK +++LDG ELE G + LW+ K +++P+ + +VH +Y ++GA Sbjct: 6 IKKKLDKNSVVILDGGNGGELEQIGAKMDKDLWAGKSAIDDPDKLFQVHENYIKSGADVI 65 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYG 126 + +Y TP G E ++ K+V++A KA + E VAGSV G Sbjct: 66 TSNTYAITPISMKEYGY-EKFTQEWNKKTVDIALKAAASTEREIA------VAGSVSTSG 118 Query: 127 AYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAY 186 ++ + ++ L DAG DL+ E + + E ++ Sbjct: 119 SW----------DKLTKNEITPGFSEQLTILSDAGVDLIILEAMTSKDETVESIIECSSK 168 Query: 187 PRARAWFSFTL---RDSEHLSDG--TPLRDVVALLAGYPQVV----------ALGINCIA 231 W S + + L G + + A Y + + + Sbjct: 169 INLPVWLSISCAMNNEEGKLMHGYQESVTNSKAQFYDYLENSLLKFTQLHKGPILVAHSD 228 Query: 232 LENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARL 291 ++ T+ A++ L + + YPN+G Y + + W GA++ Sbjct: 229 IKVTSEAVKILKKIHKGSIGAYPNNG--YFEKPNWKLVDDISPSSYLEEAKSWVLNGAQI 286 Query: 292 IGGCCRTTPADIAAL 306 IGGCC P I A+ Sbjct: 287 IGGCCGVGPDKIKAI 301 >UniRef50_C0ADK0 Homocysteine S-methyltransferase n=1 Tax=Opitutaceae bacterium TAV2 RepID=C0ADK0_9BACT Length = 306 Score = 213 bits (542), Expect = 8e-54, Method: Composition-based stats. Identities = 78/317 (24%), Positives = 118/317 (37%), Gaps = 31/317 (9%) Query: 3 QNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAG 62 + + L + L L DGA T+L+ G +S + ++E P+ ++ VH Y AG Sbjct: 5 RTDRLLSTLAA-RPLQCDGATGTQLQQLGLRPGES--CERWVIEQPDRVKLVHQRYLDAG 61 Query: 63 AQCAITASYQATPAGFAARGL-DEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGS 121 A T ++ T AA G DEA++ + + LAR+ V G Sbjct: 62 ADLLTTNTFGGTTLALAAHGFTDEARAAEINRAAARLAREVA---------GERAWVLGD 112 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 +GP+G L E + QA ALL+ GAD + ET+ + E Sbjct: 113 MGPFGGILEPYGETESAVAAAAFRAQA------AALLEGGADAILVETMSDPVEAALAVA 166 Query: 182 LLTAYPRARAWFSFTLR-----DSEHLSDGTPLRDVVALLAGYPQVVALGINCIAL---- 232 +FT + GT + V + +G NC Sbjct: 167 AAREAGAQVVIATFTFQHMAAVADFRTMMGTDVPAAVRAVLD-AGAQVVGANCGTELSLD 225 Query: 233 ENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLI 292 + A Q + P++V PN+G + A A + G R++ Sbjct: 226 DYALLAGQLVAAAQGRPVIVQPNAGSP--VRDGDAISYRTTPADFAGAAACYLKLGVRIV 283 Query: 293 GGCCRTTPADIAALKAR 309 GGCC TTPA IAA A Sbjct: 284 GGCCGTTPAHIAASAAM 300 >UniRef50_B2AAZ0 Predicted CDS Pa_1_5620 n=2 Tax=Sordariales RepID=B2AAZ0_PODAN Length = 371 Score = 212 bits (540), Expect = 1e-53, Method: Composition-based stats. Identities = 95/373 (25%), Positives = 142/373 (38%), Gaps = 75/373 (20%) Query: 1 MSQN--NPLRALLDKQDILLLDGAMATELEA-RGCNLAD--SLWSAKVLVENPELIREVH 55 MS P+ + I LDG + T LE G ++ LWS+ +L+ + + + + Sbjct: 1 MSIRFQTPIMEGRKPRTIKFLDGGLGTTLETIHGVKFSESTPLWSSHLLLTDLQTLADCQ 60 Query: 56 LDYYRAGAQCAITASYQATPAGFAA-------RGLDEAQSKALIGKSVELARKAREAYLA 108 + + +AGA TA+YQA+ GF G+ + +V +AR+A Sbjct: 61 MSFAKAGADVITTATYQASINGFKNTKTENWPNGVPLPNIGHFLKDAVSIARRAAGKVGG 120 Query: 109 ENPQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSV-----EAFQAFHRPRVEALLDA--- 160 VA S+GPYGA + +EY G Y + +H R + Sbjct: 121 R--------VALSLGPYGATMIPSTEYTGHYDIEPSQDIVDKLFHWHSERYNLYVQVPNL 172 Query: 161 --GADLLACETLPNFSEIEALAELLTA-------------YPRARAWFSFTLR-DSEHLS 204 +A ET+P EI A+ L A Y W S D + + Sbjct: 173 LFDVSYIAFETIPRLDEILAIRRFLNADISGGVKLGPREFYHDIPVWISVLFPSDDDKMP 232 Query: 205 DGTPLRDVVALLA----GYPQVVALGINCIALENTTAALQHLHGLTVL-----------P 249 DGT + D VA + G +GINC + ++ Sbjct: 233 DGTSVEDAVAAMISKEFGSKTPQFVGINCTQVSKLEGLVRQFTKAVEKLVATGAVEKWPG 292 Query: 250 LVVYPNS---GEHYDAVSKTWHHHGE----HCA------QLADYLPQWQAAG---ARLIG 293 LV+YP+ GE Y+ +K W GE QLA + + G + LIG Sbjct: 293 LVLYPDGTKVGERYNTATKEWEISGEGSKKTPEDVSWERQLAMVVKEAYDTGGWSSFLIG 352 Query: 294 GCCRTTPADIAAL 306 GCCRTTP +I L Sbjct: 353 GCCRTTPENIQRL 365 >UniRef50_B7VQ49 Homocysteine S-methyltransferase family protein n=17 Tax=Vibrionales RepID=B7VQ49_VIBSL Length = 301 Score = 212 bits (540), Expect = 1e-53, Method: Composition-based stats. Identities = 81/314 (25%), Positives = 130/314 (41%), Gaps = 36/314 (11%) Query: 11 LDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITAS 70 ++ + + +LDG M EL+ G + LWSA+ L+E P+ + + H ++ AGA+ IT S Sbjct: 1 MNMKTLTILDGGMGRELKEIGAPFSQPLWSAQALIEAPDFVSQAHQNFVDAGAEILITNS 60 Query: 71 YQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLA 130 Y P L E + L S ELA+ + + T+ VAG++ P Sbjct: 61 YACVPFHLGEE-LFEQRGFELAALSGELAKAVAD------NASHTIKVAGAIPP------ 107 Query: 131 DGSEYRGDYHCSVEAFQAFHRPRVEALLDA---GADLLACETLPNFSEIEALAELLTAYP 187 YR D EA P ++ L DA DL ET+ + E E++ +L Sbjct: 108 PFGSYRPDLFKVEEAA-----PIIQTLYDAQDPNIDLWIAETICSLQEFESIHAVLKQ-S 161 Query: 188 RARAWFSFTLRDSE----HLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLH 243 +++F+L D++ ++ G + D + LA + NC E A+ Sbjct: 162 NKPCYYAFSLEDTKGDSANIRSGESVTDSIK-LACQSNAKGIMFNCSVPEVMDQAIIDAK 220 Query: 244 GL-----TVLPLVVYPNSGEH----YDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGG 294 + + L + VY N+ ++A Y +W A GA +IGG Sbjct: 221 KVIGELGSDLEIGVYANNFAPISSEHEANDMLQEIRELDGQGYLVYAKRWHALGANIIGG 280 Query: 295 CCRTTPADIAALKA 308 CC P I AL Sbjct: 281 CCGIGPKHIQALAD 294 >UniRef50_A3JFK5 Putative uncharacterized protein n=1 Tax=Marinobacter sp. ELB17 RepID=A3JFK5_9ALTE Length = 303 Score = 211 bits (538), Expect = 2e-53, Method: Composition-based stats. Identities = 77/301 (25%), Positives = 127/301 (42%), Gaps = 24/301 (7%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 + ++LLDG + E+ R N++ +LWS V+ E P+++ VH D+ RAGA+ +Y A Sbjct: 2 RPVVLLDGGLGQEIYRRAANVSSALWSVAVMHEQPDVVTAVHSDFIRAGAKTLSLNTYAA 61 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 TP+ G Q A+ + EL +A + + +AG + P Sbjct: 62 TPSRLLRHG-QLEQLAAIHQNAFELLGQAVK------ATGACVDIAGCLPPL------AG 108 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWF 193 Y+G S E + + V+ A AD+L ET+ N E A + Sbjct: 109 SYQGQPARSFEDLRDEYSVLVK--QQAVADVLLIETMTNTLEACAACAAASEL-GKPYGV 165 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVY 253 +F L L G L + VA ++ Y A+ +NC E +AA+ L L + Y Sbjct: 166 AFRLEADGKLMSGETLAEAVAAVSPYS-PTAVMLNCCDPELISAAMPELVRLHPC-VGGY 223 Query: 254 PNSGEHYDAVSKTWHHH------GEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 N+ + +A+++ ++ QW GA +IGGCC TP + + Sbjct: 224 ANAFKSVEALAQGGSVDALEARADISPQAYVAHVRQWLDDGATVIGGCCEITPEHVRHIV 283 Query: 308 A 308 Sbjct: 284 E 284 >UniRef50_B0MM61 Putative uncharacterized protein n=1 Tax=Eubacterium siraeum DSM 15702 RepID=B0MM61_9FIRM Length = 414 Score = 211 bits (538), Expect = 2e-53, Method: Composition-based stats. Identities = 64/306 (20%), Positives = 126/306 (41%), Gaps = 26/306 (8%) Query: 4 NNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGA 63 +NP+ + + +LLDG T LE G + ++ +A+ + NPE + E+ + AG+ Sbjct: 3 SNPVSQDIPIRLPILLDGGTGTGLEKYGYD--HTVSTAQFVCANPEALIELQQGFLDAGS 60 Query: 64 QCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVG 123 Q TA++ A A G+ E +++ L + ++ + L+AG + Sbjct: 61 QILYTATHGANCENLKAYGV-EDKTEQLNAAAAKI---------TYDSFHEKALIAGCLS 110 Query: 124 PYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 G Y+ +Y + + +R +V+AL D+ ET+P + A Sbjct: 111 STGLYIEPYGDY------TFTEIMSVYRQQVKAL-SPYCDMFVIETVPALWNMRAAVLAC 163 Query: 184 TAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLH 243 + + + + GT + + +L + A G+NC + + + + Sbjct: 164 KK-ENKPIIATMKVDEDGETAIGTNVLCTLLVLQAM-GISAFGLNCTSADLCPDIISEIA 221 Query: 244 GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADI 303 +PL+V P++ D ++ + A + + +GA + GGCC T I Sbjct: 222 PYAKIPLIVKPSAVYEQDGERQSI-----SPEEFAFAVKKSVLSGAEIAGGCCGTGKEHI 276 Query: 304 AALKAR 309 AAL+ Sbjct: 277 AALREM 282 >UniRef50_B9NLU8 Homocysteine S-methyltransferase family protein n=4 Tax=Rhodobacteraceae RepID=B9NLU8_9RHOB Length = 309 Score = 211 bits (538), Expect = 2e-53, Method: Composition-based stats. Identities = 84/304 (27%), Positives = 122/304 (40%), Gaps = 29/304 (9%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 DI LLDG++ EL R + LWS +V+++ P+L+ +VH DY+R GA A T +Y Sbjct: 3 DITLLDGSIGQELVKRSGDQPTPLWSTQVMMDRPDLVGDVHADYFRRGATVATTNTYALH 62 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 + G+ E + +L+ ++ A +A +AG++GP + Sbjct: 63 RSRLRRIGM-EDKLASLVDAALSQAERAC--------VGSEGQIAGALGPV------LAS 107 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 YR D + A V+ + D DL ET+ + E E A W + Sbjct: 108 YRPDLKPDPDEAAARFSELVQLMADR-VDLFLIETVSSVLEGEGALRGT-ANCGKPVWLA 165 Query: 195 FTL--RDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVV 252 ++ D L G L D + L V A+ INC E AAL + L P Sbjct: 166 VSVNDEDGTRLRSGERLAD-IQPLIARFDVAAVLINCSKPEAIPAALDVIA-LMGRPFGA 223 Query: 253 YPNSGEHY--------DAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 Y N H V H A A + QW A GA ++GGCC P I Sbjct: 224 YANGFSHIADAFLTEAPTVDVLEQRHDLGPAAYAAHAMQWVAQGATIVGGCCEVGPDHIE 283 Query: 305 ALKA 308 L Sbjct: 284 TLAR 287 >UniRef50_D2S8U0 Homocysteine S-methyltransferase n=12 Tax=Actinomycetales RepID=D2S8U0_9ACTO Length = 314 Score = 211 bits (537), Expect = 3e-53, Method: Composition-based stats. Identities = 119/304 (39%), Positives = 158/304 (51%), Gaps = 22/304 (7%) Query: 6 PLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQC 65 PL L + +LDG +AT+LEA+G +L+ LWS+++L + PE + H + AGAQ Sbjct: 5 PLATALAAGPV-VLDGGLATQLEAQGHDLSSELWSSRLLHDAPEAVVAAHAAFAAAGAQV 63 Query: 66 AITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY 125 A TASYQ + G AA GLD +++ L+ +SV LA + A +AGSVGPY Sbjct: 64 ATTASYQVSVEGLAAAGLDATEARRLVVRSVHLAER----------GAPDAWIAGSVGPY 113 Query: 126 GAYLADGSEYRGDYHCS--VEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 GA LADGSEY G Y V+ + +HRPR+E L +AGAD+LACET+P + Sbjct: 114 GAALADGSEYTGAYADEIGVDRLRQWHRPRMEWLAEAGADVLACETVPAAA-EAEALLEE 172 Query: 184 TAYPRARAWFSFT--LRDSE--HLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAAL 239 W S T L G P +V A+ VVA+G+NC + AA Sbjct: 173 ADMLGMPVWLSLTTVLDSDGVVRTRRGEPAGEVFAMARDLDAVVAVGVNCTDPDGVLAA- 231 Query: 240 QHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 G+ P+VVYPNSGE +DA + W W AGARL+GGCCR Sbjct: 232 VTAAGVAGRPVVVYPNSGERWDAAGRRWTGTAGLSPH---NALTWVHAGARLVGGCCRVG 288 Query: 300 PADI 303 P I Sbjct: 289 PRSI 292 >UniRef50_B6AUX0 Homocysteine S-methyltransferase n=1 Tax=Rhodobacterales bacterium HTCC2083 RepID=B6AUX0_9RHOB Length = 298 Score = 210 bits (536), Expect = 3e-53, Method: Composition-based stats. Identities = 80/305 (26%), Positives = 121/305 (39%), Gaps = 28/305 (9%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 D++L DG M EL R + LWS +V+++ P L+ +V D++ AG+ A SY Sbjct: 3 DVMLFDGGMGQELVHRAGDKPTPLWSTQVMMDKPGLVADVSRDFFAAGSTVATLNSYAIQ 62 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 G+ E Q L +++ + A A+ + +AGS+GP A Sbjct: 63 RDRLVPVGI-EDQFDTLHSMALKEGQDAVAAHGS-------GRLAGSMGPLAA------S 108 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 YR D H S + + + + DL+ CET+ + + + + Sbjct: 109 YRPDIHPSADIAVPLYTEVAQKFV-GNVDLIVCETVVSLEHTRCILAGAKTA-NLPIYCA 166 Query: 195 FTL--RDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVV 252 F++ D L G P+ + + VVA+ NC A E AL L T LP Sbjct: 167 FSVSDEDGSKLRSGEPVLEAAQIAKDM-GVVAVMANCSAPEVIPTALNELAK-TSLPFGA 224 Query: 253 YPNSGEH--------YDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 Y N V AD++ W GA LIGGCC +PA IA Sbjct: 225 YANGFTKISDGFLKDRPTVDALTLRKDFSPDLYADHVMAWVDQGATLIGGCCEVSPAHIA 284 Query: 305 ALKAR 309 + R Sbjct: 285 EIAKR 289 >UniRef50_A8SCX4 Methylenetetrahydrofolate reductase n=3 Tax=Clostridiales RepID=A8SCX4_9FIRM Length = 605 Score = 210 bits (535), Expect = 4e-53, Method: Composition-based stats. Identities = 75/300 (25%), Positives = 109/300 (36%), Gaps = 33/300 (11%) Query: 9 ALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAIT 68 L Q LL DG M T + + +PE I VH Y AGA T Sbjct: 16 RKLLAQRPLLFDGGMGTY-----YKAKPGQECEQANLTDPEGILAVHRAYLAAGADAIKT 70 Query: 69 ASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 ++ + AA + + L +LA KA A V +GP Sbjct: 71 NTF--SLPRLAAA--QQPGWEQLADAGWQLAVKAAGETGAA--------VFADLGP---- 114 Query: 129 LADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA-YP 187 A +E + + + GA ETL + L P Sbjct: 115 -APDTENLP--------AEQVYLAVAKRFALLGARNFLFETLSAEDGVLEAIRALKQTVP 165 Query: 188 RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTV 247 A SF + + +G ++V +A V A+G+NC++ AL G Sbjct: 166 EAFVLVSFAVLPDGYTREGRYCAELVRRVAQSGVVDAVGLNCVSAPGAMRALVQQLGDAG 225 Query: 248 LPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALK 307 LPL V PN+G V++ + A L + + G R++GGCC TTP IAAL+ Sbjct: 226 LPLSVMPNAGYP--VVARAQVRYQGKPEYFARELSRLASEGVRILGGCCGTTPQHIAALR 283 >UniRef50_C4GEB4 Methylenetetrahydrofolate reductase n=1 Tax=Shuttleworthia satelles DSM 14600 RepID=C4GEB4_9FIRM Length = 670 Score = 209 bits (533), Expect = 8e-53, Method: Composition-based stats. Identities = 77/325 (23%), Positives = 117/325 (36%), Gaps = 38/325 (11%) Query: 7 LRALLDKQDILLLDGAMATELEARGCNLAD-SLWSAKVLVENPELIREVHLDYYRAGAQC 65 +R L K+ LL DGA T + + S + V V P+ ++ +H Y AGA Sbjct: 3 IREYL-KEHTLLFDGAFGTYYTKQFRPEKEESFFPEYVNVSRPDRVKAIHRKYLSAGAHA 61 Query: 66 AITASYQATP----------AGFAARGLDEAQSKALIGKS----------VELARKAREA 105 T ++ A P G A+ L S E AR+A + Sbjct: 62 IKTNTFGAYPGILMKDAGETKKLITAGFSLAEEALLNHLSKDVKNRPETTGEFARRAGQE 121 Query: 106 YLAENPQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLL 165 AE + +GP + ++ +++ L+ GA Sbjct: 122 RSAEASGEEDYFIFADLGP-------------APGEEEKERILAYQMAIDSFLETGARYF 168 Query: 166 ACETLPNFSEIEALAELLT-AYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVA 224 ETLP + L P A SF + S+G RD++A AG V A Sbjct: 169 LFETLPEEKTVLEAIRYLKDQCPGAYTISSFAVMPDGFSSEGCNYRDMLAAAAGESAVDA 228 Query: 225 LGINCIALENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQW 284 +G+NC++ L PL++ PN+G +T + A L + Sbjct: 229 VGLNCMSSVWHMDHLIRQIPDPGKPLLLMPNAGYPVVRGYRTVFE--GNADYFARILARD 286 Query: 285 QAAGARLIGGCCRTTPADIAALKAR 309 G ++GGCC TTP I L R Sbjct: 287 AGQGVAMVGGCCGTTPDHIRLLADR 311 >UniRef50_B8I637 Methylenetetrahydrofolate reductase n=2 Tax=Clostridium RepID=B8I637_CLOCE Length = 615 Score = 207 bits (528), Expect = 3e-52, Method: Composition-based stats. Identities = 58/301 (19%), Positives = 112/301 (37%), Gaps = 32/301 (10%) Query: 9 ALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAIT 68 + +D L DGA+ T + + E I +H +Y +AG T Sbjct: 33 NIFSNRDYFLFDGAIGTY---YSLKYRSNTPCELANINERENIFNIHSEYIQAGVNAIKT 89 Query: 69 ASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 ++ A G ++++ + +I ++A +A ++V +GP Sbjct: 90 NTFSANRFSL---GCNQSEVEKIIKSGYDIAVQAC--------SGQEVVVFADIGPI--- 135 Query: 129 LADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT-AYP 187 + + + + V+ L+ GA ET N + +A + P Sbjct: 136 -------PDEKGINPKE---EYIKIVDIFLECGAKNFLFETFANTDILIGVAAYIRLRLP 185 Query: 188 RARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLT 246 A SF + + +G D++ + V A+G+NC + ++ + Sbjct: 186 EAVVVTSFAVYPDGYSKEGLFYVDLMDKMYASGLVDAVGLNCISGPAHMYRLIKK-ADIR 244 Query: 247 VLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 +++ PNSG +T + ++ A+ L + G ++ GGCC TTP IAA Sbjct: 245 GKSIIIMPNSGYPGSERGRTV--YSDNSEYYAEKLLDLKNLGVKIFGGCCGTTPKHIAAA 302 Query: 307 K 307 Sbjct: 303 A 303 >UniRef50_C5RGW2 Methylenetetrahydrofolate reductase n=1 Tax=Clostridium cellulovorans 743B RepID=C5RGW2_CLOCL Length = 609 Score = 207 bits (526), Expect = 6e-52, Method: Composition-based stats. Identities = 54/299 (18%), Positives = 102/299 (34%), Gaps = 31/299 (10%) Query: 13 KQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQ 72 + +L+ DGAM T A CN + + + I +H +Y +AGA T ++ Sbjct: 4 NERLLIFDGAMGTY-YASSCNNPLPKC-ELANIHDKKTILNIHKEYIKAGAGAIKTNTFG 61 Query: 73 ATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADG 132 A D K I E+A++A + +LV +GP Sbjct: 62 ANKISLE---CDFDVMKEAIVSGYEIAKEA--------TEGTDVLVFADIGPIP------ 104 Query: 133 SEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAW 192 ++ ++ L GA ET + + ++E + Sbjct: 105 -------FLEKVDLWVGYKEIIDIFLSLGASNFIFETFSSDEYLIEISEYIKEKNSKAFI 157 Query: 193 FS-FTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPL 250 + F + G + ++ + + A G NC + + L + + Sbjct: 158 LTEFAVSPEGVTRLGKSGKKLLNTMLKAKTIDACGFNCFSGPYHLLQYSKTL-DIKDKTI 216 Query: 251 VVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKAR 309 + PNSG ++ + A+ + + G ++GGCC TTP I + + Sbjct: 217 SMMPNSGYPSMINNRVF--FDNTKEYFAEQMLEIARQGVTILGGCCGTTPEYIKEMVDK 273 >UniRef50_UPI00016C0A13 5-methyltetrahydrofolate--homocysteine methyltransferase, putative n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016C0A13 Length = 276 Score = 205 bits (523), Expect = 1e-51, Method: Composition-based stats. Identities = 58/294 (19%), Positives = 110/294 (37%), Gaps = 25/294 (8%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 +I LDGA+ + L + +++ ++ + +P+L+ ++H +Y AGAQ + ++ Sbjct: 1 MNITFLDGALGSNLLQ---TASANVF--ELNLTHPDLVAQLHREYVAAGAQIVASNTFGV 55 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 A LI +++A A T VA +GP A L Sbjct: 56 NRISAAKTKYA---VGELIEAGLQIAFDAI-------SDTDTAKVAFDIGPLAALLEPFG 105 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWF 193 + S E + + + + + + ET + E+ LA + Sbjct: 106 D------LSEEECSEIYAEILASGISQKPNYIFFETFMDV-EMLKLAVAVADNYDVPILA 158 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIA-LENTTAALQHLHGLTVLPLVV 252 + + G + D +A ++ + VVA+G+NC N +Q + P+++ Sbjct: 159 AMSFLPVGKTIMGNSVDDFLAAMSKFKNVVAVGLNCSDTPTNLAKVVQEFAAKSSWPIII 218 Query: 253 YPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 PN+G + + A + +GGCC TTP I L Sbjct: 219 KPNAGLPQSVDGE--ISYATDAEFFAAEMAYALQIPNAYVGGCCGTTPLHIQQL 270 >UniRef50_C8VHP4 Homocysteine S-methyltransferase (Eurofung) n=5 Tax=Eurotiomycetidae RepID=C8VHP4_EMENI Length = 355 Score = 205 bits (522), Expect = 1e-51, Method: Composition-based stats. Identities = 94/351 (26%), Positives = 144/351 (41%), Gaps = 57/351 (16%) Query: 14 QDILLLDGAMATELEARGCNL----ADSLWSAKVLVENPELIREVHLDYYRAGAQCAITA 69 ILLLDG + T LE+ N+ LWS+ +L+ +P ++ H +Y AGA +TA Sbjct: 1 MKILLLDGGLGTTLESYPFNITFTSETPLWSSHLLISSPSTLQSAHRAFYDAGADILLTA 60 Query: 70 SYQATPAGFAARGLDE--AQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGA 127 +YQ++ GFA + + ++ L R A + + PQ VA S+GPYGA Sbjct: 61 TYQSSIEGFARTDASHTINDAGDYMRSAIPLVRGAIPSSARQRPQQCR--VALSLGPYGA 118 Query: 128 YLAD-GSEYRGDYHCS---VEAFQAFHRPRVEALLD-----AGADLLACETLPNFSEIEA 178 ++ +EY G Y +A + +H R+ +D D +A ETL E+ A Sbjct: 119 TMSPVAAEYTGAYPPEMDGEDALRQWHAGRLNVFVDDRESWDQVDFVAFETLIRADEVCA 178 Query: 179 LAELLTAYP--------RARAWFS--FTLRDSEHLSDGTPLRDVVALLAGYPQVVALGIN 228 + + R W F + + + V G P+ +G+N Sbjct: 179 VRGAMKDVCVGPEIHRRRKPWWICGVFPAEEVDRTQVRQWVDAAVGQRPGLPRPWGIGLN 238 Query: 229 CIALENTTAALQHLH--------------------GLTVLP-LVVYPNS--GEHYDAVSK 265 C +EN + + + P LV+YP+ GE YD V+K Sbjct: 239 CTRIENVAKIVAIMRDELHCLLSRGKEDGFVDEWDAASGKPWLVLYPDGTKGEKYDPVTK 298 Query: 266 TWHHHG-----EHCAQLADYLPQWQA--AGARLIGGCCRTTPADIAALKAR 309 TW L D + ++GGCCR PADIAAL+ R Sbjct: 299 TWVARETVVRCPWDESLWDVVQGQSEGDWEGIIVGGCCRAGPADIAALRRR 349 >UniRef50_UPI000190A21A homocysteine S-methyltransferase n=2 Tax=Rhizobium etli RepID=UPI000190A21A Length = 303 Score = 205 bits (522), Expect = 2e-51, Method: Composition-based stats. Identities = 83/317 (26%), Positives = 121/317 (38%), Gaps = 49/317 (15%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 I +LDG M+ EL G L WSA L+ +P+++REVH ++ AG++ + SY P Sbjct: 4 IRILDGGMSRELLRLGAELKQPEWSALALINSPDIVREVHKEFIEAGSEIIFSNSYALVP 63 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 + + ALI + LAR+A ++ +LVAGS+ P Sbjct: 64 FHIGEDRFRKEGA-ALIRLAGRLAREAADSV-----TDRKVLVAGSLPPIFGSYEP---- 113 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 + E Q + + VE L D+ ETL +E EA+ E + A W SF Sbjct: 114 ---QNFRPERVQDYLKVLVENLA-PFVDIWLGETLSLIAEGEAVREAVAA-SGKPFWISF 168 Query: 196 TLRDSE--------HLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGL-- 245 TL D E L G + + A NC E AA++ + Sbjct: 169 TLADDEADIKSGEPKLRSGESVEAAASWAVS-SGAEAFLFNCSKPEVMRAAVETAARVFR 227 Query: 246 -TVLPL----VVY-----------PNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGA 289 T P+ + PN G H + + + W AGA Sbjct: 228 KTDAPIENRRLCQCLRRGTGAHRPPNEGLHETRG-------DLNDDVYSRFACSWAEAGA 280 Query: 290 RLIGGCCRTTPADIAAL 306 +IGGCC A I L Sbjct: 281 TIIGGCCGIGAAHIHRL 297 >UniRef50_A9GUQ7 Putative homocysteine S-methyltransferase family protein n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9GUQ7_SORC5 Length = 309 Score = 205 bits (522), Expect = 2e-51, Method: Composition-based stats. Identities = 92/297 (30%), Positives = 126/297 (42%), Gaps = 27/297 (9%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENP--ELIREVHLDYYRAGAQCAITASYQA 73 I++LDG + TEL ARG LWSA L++ +++R +H DY RAGA +++ Sbjct: 20 IVVLDGPLGTELAARGVETPAPLWSAAALLDARGRDVVRAIHRDYARAGATVHTANTFRT 79 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 R A L ++V LAR+A + VAGS+ P Sbjct: 80 ------RRRQAGAAWAELASRAVSLAREAV------RGEGPRHRVAGSIAPL------ED 121 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWF 193 YR D S + HR AL AG DLL CET P+ E E A AW Sbjct: 122 CYRPD--LSPADARQEHRELARALASAGVDLLLCETFPHVGEALVALEEAVA-TGVEAWV 178 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVY 253 SFT L + A A A+ +NC T A ++ L +P Y Sbjct: 179 SFTAGPGSDLLSPEDVGRA-AREAAARGASAVLVNCTPATRTLAHIERLAA-CGVPFGAY 236 Query: 254 PNSGEHYDAVS--KTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 N+G + + G A+ A+ +W AGA ++GGCC T P IAAL+A Sbjct: 237 ANAGAEAEGLGWGVGVDQRGSAAARYAELARRWLEAGATIVGGCCGTGPGHIAALRA 293 >UniRef50_Q65V50 MHT1 protein n=3 Tax=Pasteurellaceae RepID=Q65V50_MANSM Length = 298 Score = 205 bits (522), Expect = 2e-51, Method: Composition-based stats. Identities = 76/311 (24%), Positives = 105/311 (33%), Gaps = 32/311 (10%) Query: 14 QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQA 73 I +LDG M+ EL R WSA L E P ++ VH D+ GA+ T SY Sbjct: 1 MPITILDGGMSRELMRRNAPFRQPEWSACALYEEPSAVQAVHEDFIAHGAEVITTDSYAV 60 Query: 74 TPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGS 133 P + K L + LA+ A + + +AGS+ P Sbjct: 61 VPFHIGEQRF-HTDGKTLADLAGRLAKSAVKNSGVLTTK-----IAGSLPP------MFG 108 Query: 134 EYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWF 193 YR D E F +P ++ L D+ CET E ++ + L W Sbjct: 109 SYRADL-IQPERFAEIAQPLIDGL-SPYVDIWLCETQSAIIEPVSI-KALLPKDDRPFWV 165 Query: 194 SFTLRDSE-----HLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQ------HL 242 SFTL D E L G ++ V + V A+ NC E AL Sbjct: 166 SFTLTDDELTCEPQLRSGETVKSAVEKMVDL-GVDAILFNCCQPEVIGEALAVTTATLTA 224 Query: 243 HGLTVLPLVVYPNSGEHYD-----AVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCR 297 T + Y N+ + +W A GA +IGGCC Sbjct: 225 LNATHIQTGAYANAFAPQPKDATANDGLDEVRKDLDPPAYLAWAKKWTAQGASIIGGCCG 284 Query: 298 TTPADIAALKA 308 I L Sbjct: 285 IGVEYIETLAK 295 >UniRef50_C0EVI7 Methylenetetrahydrofolate reductase n=1 Tax=Eubacterium hallii DSM 3353 RepID=C0EVI7_9FIRM Length = 638 Score = 205 bits (521), Expect = 2e-51, Method: Composition-based stats. Identities = 68/318 (21%), Positives = 119/318 (37%), Gaps = 32/318 (10%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYR 60 M N +R L+ LL DGAM T ++ + + S + + NP L+RE+H Y + Sbjct: 1 MRMN--IREYLENHK-LLTDGAMGTYFDS--IEKENYICSEEANITNPALVREIHRSYVK 55 Query: 61 AGAQCAITASYQATPAGF------AARGLDEAQSKALIGKSVELARKAREAYLAENPQAG 114 GAQ + ++ A F A + K LI +LA++ + E Sbjct: 56 NGAQLLRSNTFLANEGTFLSLTQAKAEAFENITLKQLIIAGYQLAKETAQEVYQEEY--- 112 Query: 115 TLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFS 174 + A +GP + + ++ L+AGAD+ ET P+ Sbjct: 113 PIFAAADIGPI----------LEERDSEEADILQQYYEICDSFLEAGADIFVLETFPDTQ 162 Query: 175 EIEALAELLTA-YPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IAL 232 + +AE + P A F+L + + G + ++ + G+NC + Sbjct: 163 YVLKMAEYIRKSCPEAFIIGQFSLTPTGYSRTGFHYKTILQEATQSGLLDGAGLNCGVGA 222 Query: 233 ENTTAALQHLHGLTVLP----LVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAG 288 + L+ +P L PN G + + + L + G Sbjct: 223 AHMKKFLKSYIEEFGVPEDMVLTSLPNCGYPQIVRGHAV--YSDSVPYFGEKLGEISELG 280 Query: 289 ARLIGGCCRTTPADIAAL 306 +++GGCC TTP I + Sbjct: 281 VQVLGGCCGTTPEYIGEI 298 >UniRef50_D1Z559 Whole genome shotgun sequence assembly, scaffold_4 n=1 Tax=Sordaria macrospora RepID=D1Z559_SORMA Length = 357 Score = 204 bits (520), Expect = 2e-51, Method: Composition-based stats. Identities = 90/336 (26%), Positives = 140/336 (41%), Gaps = 44/336 (13%) Query: 15 DILLLDGAMATELEARG---CNLADSLWSAKVLVE-NPELIREVHLDYYRAGAQCAITAS 70 + +LDG + T LE + LWS+ +LV + + + H + +AGA TA+ Sbjct: 6 PVQILDGGLGTTLEDLHGITFSFETPLWSSHLLVSGEEDKLLDCHEAFQKAGANIISTAT 65 Query: 71 YQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLA 130 YQ + GFAA ++ + IGK R LA N VA ++GPYGA + Sbjct: 66 YQTSINGFAATKAPKSGAPDGIGKEGIPHFLNRAVVLAANAAGKEGKVALALGPYGATMI 125 Query: 131 DGSEYRGDYHC---SVEAFQAFHRPRVEALLD---AGADLLACETLPNFSEIEALAELLT 184 +EY G Y A + +H+ R++ D + +A ET+P EI A+ LL+ Sbjct: 126 PSTEYSGKYDPGHQDARALEEWHKKRLDLFKDVNTNQVNYIAFETVPRLDEIVAIRNLLS 185 Query: 185 ------AYPRARAWF-SFTLRDSEHLSDGTPLRDVVALL----AGYPQVVALGINCIALE 233 + W S D E L DG+ + +VV G +GINC +E Sbjct: 186 TDKIPTSLRGRPVWISSLYPNDDEKLPDGSTVEEVVRAALTRREGLETPWGIGINCTKVE 245 Query: 234 NTTAALQHLHGLT----------VLP-LVVYPNS--GEHYDAVSKTWHHHGEHCAQLADY 280 + ++ P LV+YP+ GE Y+ ++KTW A + Sbjct: 246 KLDSLVRRYEAALQSCIDNGEPMDWPSLVLYPDGTNGEVYNTINKTWELPPGQKQPEAPW 305 Query: 281 ----------LPQWQAAGARLIGGCCRTTPADIAAL 306 Q + ++GGCC+T+P I L Sbjct: 306 EVILTNVVGAARQRGKWKSIIVGGCCKTSPELIRKL 341 >UniRef50_Q93088 Betaine--homocysteine S-methyltransferase 1 n=79 Tax=Metazoa RepID=BHMT1_HUMAN Length = 406 Score = 203 bits (516), Expect = 7e-51, Method: Composition-based stats. Identities = 67/327 (20%), Positives = 115/327 (35%), Gaps = 40/327 (12%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRA 61 + L+ +I++ DG LE RG A W+ + VE+PE +R++H ++ RA Sbjct: 8 KAKKGILERLNAGEIVIGDGGFVFALEKRGYVKAGP-WTPEAAVEHPEAVRQLHREFLRA 66 Query: 62 GAQCAITASYQATPAGFAARG---LDEAQSKALIGKSVELARKAREAYLAENPQAGTLLV 118 G+ T ++ A+ RG L++ + + + ++AR+ + G LV Sbjct: 67 GSNVMQTFTFYASEDKLENRGNYVLEKISGQEVNEAACDIARQVADE--------GDALV 118 Query: 119 AGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 AG V +YL+ SE + ++E + D L E + E Sbjct: 119 AGGVSQTPSYLSCKSE---------TEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVW 169 Query: 179 LAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTA 237 E L A + + L G P + L +G+NC + Sbjct: 170 AVETLIA-SGKPVAATMCIGPEGDL-HGVPPGECAVRLVK-AGASIIGVNCHFDPTISLK 226 Query: 238 ALQHLH-----GLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLA----------DYLP 282 ++ + L+ P + D + + E L Y Sbjct: 227 TVKLMKEGLEAARLKAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAR 286 Query: 283 QWQAAGARLIGGCCRTTPADIAALKAR 309 + G R IGGCC P I A+ Sbjct: 287 EAYNLGVRYIGGCCGFEPYHIRAIAEE 313 >UniRef50_B0PF81 Methylenetetrahydrofolate reductase n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PF81_9FIRM Length = 582 Score = 202 bits (515), Expect = 1e-50, Method: Composition-based stats. Identities = 60/292 (20%), Positives = 101/292 (34%), Gaps = 36/292 (12%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 L DGA T + D + P+ + ++H +Y +G T ++ A Sbjct: 5 RPFLFDGAFGTYYFS---KTGDEAPCELANLTAPQTVLDIHREYAASGCAALKTNTFAAN 61 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 P + +I LA++A + A V +G Sbjct: 62 PVSIPDS----VRLNEVIAAGWSLAQRAAQENGAR--------VFADIG----------- 98 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTA-YPRARAWF 193 + +A + V L+ GA ETL + +++ L+ P A Sbjct: 99 -----GICADTAEADYLTVVRHFLELGAQNFLFETLACYQDVQRAVGLIRQSVPDATVIV 153 Query: 194 SFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINC-IALENTTAALQHLHGLTVLPLVV 252 SF + + G R + PQV A+G+NC + + L+ L P+ Sbjct: 154 SFAVSQDGYSRRGLYCRALFDQAESDPQVDAVGLNCSCGPSHMRSLLRALGQRV-KPVAA 212 Query: 253 YPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIA 304 PN+G + + ++ A L GA ++GGCC TTP I Sbjct: 213 MPNAGYPSSLNGRVFFE--DNAGYFAQQLSALYMDGADILGGCCGTTPQHIR 262 >UniRef50_A9QPD6 Methylenetetrahydrofolate reductase n=1 Tax=Methylacidiphilum infernorum V4 RepID=A9QPD6_METI4 Length = 617 Score = 202 bits (514), Expect = 1e-50, Method: Composition-based stats. Identities = 67/310 (21%), Positives = 123/310 (39%), Gaps = 24/310 (7%) Query: 1 MSQNNPLRALLDK--QDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDY 58 M + L+D+ + +L+ DGA+ T L + G + ++ + P LI +VH DY Sbjct: 1 MPWEKRMATLIDRLNESLLIGDGALGTYLYSLGVP--RNYCIEELSLSQPYLIEKVHKDY 58 Query: 59 YRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLV 118 AGA+ + +A + L E + K ++ S+ LA+KA + Sbjct: 59 IEAGAKIIRANTAEANAYHLSFFKL-EKKLKEIVSSSIGLAKKALGF--------KEGWI 109 Query: 119 AGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEA 178 AG++ P D + + + ++ LL+ G DLL ET + S++ Sbjct: 110 AGTINPIWVR-------PADPPIDLSTRRTLYEEQISLLLEEGCDLLFFETFTDLSDLLL 162 Query: 179 LAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGIN-CIALENTTA 237 EL + + LS G L++ + L + +GIN ++ + Sbjct: 163 GLELARNKGAQFLFAFVASFEEGKLSSGQSLKEAFSKLRE-AGALLVGINGASGVQASLH 221 Query: 238 ALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCR 297 L+ + L YPN+G+ K + + + ++ G L+GG Sbjct: 222 LLEEIEKKETDLLGAYPNAGKPEFYEGKL--TYSASPSYFGQNVLKFVEEGLNLLGGDYG 279 Query: 298 TTPADIAALK 307 T P +AA+ Sbjct: 280 TEPVHVAAMA 289 >UniRef50_B8PAR1 Predicted protein (Fragment) n=1 Tax=Postia placenta Mad-698-R RepID=B8PAR1_POSPM Length = 380 Score = 201 bits (511), Expect = 3e-50, Method: Composition-based stats. Identities = 104/381 (27%), Positives = 149/381 (39%), Gaps = 93/381 (24%) Query: 16 ILLLDGAMATELEA-RGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 +L+LDG T LE +++ LWSA+ + +NPELI HL + RAGA +T++YQ Sbjct: 1 VLILDGGFGTTLEDVFHQDISTPLWSARPIEDNPELIIAAHLAFLRAGADVILTSTYQCA 60 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQA------------GTLLVAGSV 122 F G ++ K+V LA +AR Y E + +A S+ Sbjct: 61 FQTFERSGYTREDGVRILRKAVLLATEARRQYKEEGAPDDTSTGLSGTAHVRDIKIALSL 120 Query: 123 GPYGAYLADGSEYRGDYHCSV-----------------------------EAFQAFHRPR 153 GP+GA L+ E+ G Y A AFH R Sbjct: 121 GPFGATLSPAQEFDGFYPPPYGPKGLSQEGGNYNAFPDSDDGKAQEEKAVAALTAFHLER 180 Query: 154 VEALLD-----AGADLLACETLPNFSEIEALAELLT-------AYPRARAWFSFTLRDSE 201 + AL++ A D +A ET+P EI A+ + A W S T+ Sbjct: 181 LRALVEDVETWAAIDFVAFETVPLVREIRAIRHAMELLVQENGASAAKPWWIS-TVYPGG 239 Query: 202 HLSDGTPLRD-------VVALLAG--------YPQVVALGINCIALENTTAALQHLHGL- 245 + VV + G P LG+NC + L+ + + Sbjct: 240 RFPQERSPGEGRLTVRIVVEAIMGEGRLGAPQSPAPWGLGVNCTEPQFIGGLLKEMTNIM 299 Query: 246 ----------TVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQ-LADYLPQWQA----AGAR 290 LVVYPN G+ YDA S+TW E Q A ++ W AG++ Sbjct: 300 EGLGNTAGRSQSPWLVVYPNRGDVYDAASQTWSKGAESIRQNWAVHV--WADVQRVAGSK 357 Query: 291 -----LIGGCCRTTPADIAAL 306 LIGGCC+T P +IA L Sbjct: 358 AWSGCLIGGCCKTGPQEIAEL 378 >UniRef50_B7G6P4 Predicted protein n=2 Tax=cellular organisms RepID=B7G6P4_PHATR Length = 346 Score = 200 bits (508), Expect = 7e-50, Method: Composition-based stats. Identities = 72/331 (21%), Positives = 122/331 (36%), Gaps = 49/331 (14%) Query: 12 DKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASY 71 + +LLDG E++ RG WSA L E+P+++R VH + AG+ T +Y Sbjct: 11 ANRPFILLDGGTGREIQQRGGPFRQPEWSALALYEDPDIVRAVHESFLNAGSTAITTNTY 70 Query: 72 QATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLAD 131 P + + L ++ LA +A+ + + GS+ P + Sbjct: 71 ALVPYHIGSDRF-RKDAPRLFSLAISLAAEAK-------GDRQHVQILGSIPP----VCG 118 Query: 132 GSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEI-----------EALA 180 E + + ++ + P + D ET+ + E +A+A Sbjct: 119 SYEPQSFDEATAKSILDWFMPVLG--DSPLVDAYLLETVGSTREARFYLQYMQSFVKAVA 176 Query: 181 ELLTAYPR------ARAWFSFTL------RDSEHLSDGTPLRDVVALLAGYPQVVA---- 224 E L + W SF + + HL G L V L + A Sbjct: 177 ESLDSLSNGTLAREKPVWLSFCIASHPGATQTPHLLTGETLTQAVHALIEEGLLTAATVP 236 Query: 225 -LGINCIALENTTAALQHLHGL---TVLPLVVYPNSG--EHYDAVSKT--WHHHGEHCAQ 276 + +NC ++ A+Q LH + + + YPN+ +A + T + + Sbjct: 237 VVLVNCCDVKLVLNAVQELHAVLSPLGIRVGAYPNAFSIPPPNAANHTLRQVDYNVTPGR 296 Query: 277 LADYLPQWQAAGARLIGGCCRTTPADIAALK 307 A W AGA ++GGCC P I AL Sbjct: 297 WAATAKSWINAGASVVGGCCGVGPKYITALA 327 >UniRef50_B1KCG4 Homocysteine S-methyltransferase n=52 Tax=Proteobacteria RepID=B1KCG4_BURCC Length = 313 Score = 199 bits (507), Expect = 9e-50, Method: Composition-based stats. Identities = 83/313 (26%), Positives = 111/313 (35%), Gaps = 37/313 (11%) Query: 16 ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQATP 75 I +LDG M EL G WSA L+E P + H + AGA SY P Sbjct: 4 ITVLDGGMGRELARMGAPFRQPEWSALALMEAPHYVGLAHDAFIAAGADVITANSYAVVP 63 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 + AR+A + + + VAGS+ P G Y Sbjct: 64 FHIGEQRFRRDGVALAALAGQL-ARQAADRAV------RPVRVAGSLPPTG------GSY 110 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 R D A V+ L D DL ET EI+A+ L A R W SF Sbjct: 111 RPDLF-DAARADAILATLVDGL-DPYVDLWLAETQSLTGEIDAVRRALGAN-RKPLWVSF 167 Query: 196 TLRDS--------EHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQH------ 241 TLRD L G L + + + AL NC E AA++ Sbjct: 168 TLRDDVGADTGAGPVLRSGQALDEAIDAAVS-ARARALLFNCSQPEAMGAAIETVQRTLA 226 Query: 242 -LHGLTVLPLVVYPNSGEHYDAVSKT-----WHHHGEHCAQLADYLPQWQAAGARLIGGC 295 + L + Y N+ A ++ A + QW A GA+++GGC Sbjct: 227 GMGAGAALMIGAYANAFPPQRADARANEELDVLRGDIDPPGYAKWAEQWLALGAQIVGGC 286 Query: 296 CRTTPADIAALKA 308 C P IAAL+ Sbjct: 287 CGIGPGHIAALRD 299 >UniRef50_A1DJI9 Homocysteine S-methyltransferase, putative n=4 Tax=Trichocomaceae RepID=A1DJI9_NEOFI Length = 313 Score = 198 bits (503), Expect = 3e-49, Method: Composition-based stats. Identities = 71/318 (22%), Positives = 122/318 (38%), Gaps = 23/318 (7%) Query: 6 PLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVEN---PELIREVHLDYYRAG 62 L LL + L + M T L + +S+ LV++ +LI + Y Sbjct: 2 ALPQLLSPK-PFLTECGMETCLV-YKDKVHLPCFSSLPLVDSDSSRKLISHYYDSYISVA 59 Query: 63 AQ-----CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLL 117 A T +++ GL + L +V LA++AR + ++ Sbjct: 60 ATNGTGIVLDTRTWRGATPWAQPMGLSADKLLELNHAAVRLAKEARNKAVG-GENNIPVV 118 Query: 118 VAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE 177 ++G++GP D SE ++E + +R +VE L DAG D+LA T+ N +E Sbjct: 119 ISGTMGPLRDAYEDTSE-----SITLEDAREGYREQVEVLADAGVDMLAIMTVTNLNEAI 173 Query: 178 ALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQ--VVALGINCIALENT 235 A+ EL R SF++ L G L + + VV G+NC Sbjct: 174 AVVELAKEV-RLPVVVSFSIESDGRLLGGRSLESAIRTVDEKTGGYVVYYGVNCAHPVRI 232 Query: 236 TAALQHLHGLTVLPLV-VYPNSGE-HYDAVSKTWHHHGEHCAQLADYLPQWQAA--GARL 291 +AAL+ + + + N+ +D + + + D ++ Sbjct: 233 SAALRDVPEDVRGRIGLIKGNASLKSHDELDNSGTLDRGDISAFTDGFEGVLPLVPNVKV 292 Query: 292 IGGCCRTTPADIAALKAR 309 IGGCC T + A+ R Sbjct: 293 IGGCCGTDEEHLEAIAKR 310 >UniRef50_C9SAQ6 Homocysteine S-methyltransferase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SAQ6_VERA1 Length = 355 Score = 196 bits (499), Expect = 7e-49, Method: Composition-based stats. Identities = 84/347 (24%), Positives = 134/347 (38%), Gaps = 58/347 (16%) Query: 12 DKQDILLLDGAMATEL-EARG--CNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAIT 68 +L+LDG + T L + G + + LWS+ +LV + + + D+ +T Sbjct: 5 ASNKVLILDGGLGTSLGDKYGVRFDKSTPLWSSHMLVSDQDTLLACQKDFGDVPVDIILT 64 Query: 69 ASYQATPAGFAAR-------GLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGS 121 A+YQ + GFA G+D + + ++ +A A + + VA S Sbjct: 65 ATYQFSIHGFANTRTAQFPDGIDRTKIASYARDAIAIAHSAGKENGGQ--------VALS 116 Query: 122 VGPYGAYLADGSEYRGDY---HCSVEAFQAFHRPRVEALLDAG-----ADLLACETLPNF 173 VGPYGA + G EY G Y H + E A+H R +AG +A ET+P Sbjct: 117 VGPYGACMIPGQEYTGKYDLEHDTPEDLAAWHLERFRIFEEAGGFSSPVSYIAVETMPRL 176 Query: 174 SEIEALAELL----TAYPRARAWFSFTLR-DSEHLSDGTPLRDVVALL----AGYPQVVA 224 EI A + L W + + L DG + V + Q Sbjct: 177 DEIVAARKALDDLGAKAANTPFWIACVFPGEEMALPDGASISSAVDAMLNPAVARSQPWG 236 Query: 225 LGINCIALENTTAALQHLHGLTVLP-----------LVVYPNS--GEHYDAVSKTWHHHG 271 +GINC + + H LV+YP+ GE Y+ ++TW Sbjct: 237 IGINCTKIWKLKELIAHFEAAVADQVQAGHVNEAPALVLYPDGTDGEVYNTTTQTWELPA 296 Query: 272 EH-------CAQLADYLPQWQAAGA---RLIGGCCRTTPADIAALKA 308 QLA+ + G ++GGCC+ + A +A L+ Sbjct: 297 GGKVQGAPWEEQLAEIVRDANTRGKWKQIVVGGCCKASHAHLARLRD 343 >UniRef50_B5IJ26 Homocysteine S-methyltransferase n=2 Tax=Bacteria RepID=B5IJ26_9CHRO Length = 345 Score = 196 bits (499), Expect = 8e-49, Method: Composition-based stats. Identities = 61/313 (19%), Positives = 105/313 (33%), Gaps = 27/313 (8%) Query: 16 ILLLDGAMATEL-EARGCNLADSLWSAKVLVENP---ELIREVHLDYYRAG-----AQCA 66 LL DG + T L +G L ++A L+ +L+ + Y G Sbjct: 24 PLLSDGGLETTLVFHQGIEL--PGFAAFDLLRRERGAQLLTDYFRSYLALGREAGTGFVM 81 Query: 67 ITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGT----LLVAGSV 122 T +++A PA G + +A ++V L + RE + ++G + Sbjct: 82 ETPTWRANPAWGPELGYSSEELEAANRQAVALLMELREEEERTARSDDRPDPVIQISGCI 141 Query: 123 GPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAEL 182 GP G Y D S E + FH ++ L +G DL+ TL E + Sbjct: 142 GPRG------DGYVPDQKLSAEEAEVFHSWQIGVLSRSGVDLVTAFTLSAVPEAVGIVRA 195 Query: 183 LTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYP--QVVALGINCIALENTTAALQ 240 A SFT+ L G PL + + + +NC + A L+ Sbjct: 196 ARAEA-VPVVISFTVETDGRLPSGQPLSEAIERVDAETDGAAAYFMVNCAHPSHVAAVLE 254 Query: 241 HLHGLTVLPLVVYPNSG-EHYDAVSKTWHHHGEHCAQLADYLPQWQAA--GARLIGGCCR 297 + + N+ + + LA + ++GGCC Sbjct: 255 QGGPWRERIVGLRANASRRSHAELDAAESLDEGDPDDLARLYRELSPLLPNLAVLGGCCG 314 Query: 298 TTPADIAALKARS 310 T + A+ + Sbjct: 315 TDLRHVQAIARAT 327 >UniRef50_A4EBI1 Putative uncharacterized protein n=1 Tax=Collinsella aerofaciens ATCC 25986 RepID=A4EBI1_9ACTN Length = 297 Score = 195 bits (497), Expect = 1e-48, Method: Composition-based stats. Identities = 68/295 (23%), Positives = 112/295 (37%), Gaps = 26/295 (8%) Query: 5 NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQ 64 L L + LL G M + L + A + P+ + +H Y AGAQ Sbjct: 12 EELTRRLSSET-LLAQGPMGSVLLSEYDAADIP--PAFWNLAEPQTVSRIHRLYVAAGAQ 68 Query: 65 CAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGP 124 IT ++QA+ + + + +V+ AR+A L+ GS+GP Sbjct: 69 VLITNTFQASSYALKHDQIAPS-VAEVNRGAVDDARQA-----------HPQLLLGSMGP 116 Query: 125 YGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 G E+ + + R + ALL+AG D L ET+ + ++ + Sbjct: 117 IGI------EWFAEDSVEYREIRGIAREQAHALLNAGVDGLLIETVTSIRNLQPMLAGAR 170 Query: 185 AYPR-ARAWFSFTLRDSEHLS-DGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHL 242 SF + D L DG + V + ++G+NC +L AA+ + Sbjct: 171 DAADGMPVLVSFVVDDKGDLLGDGLNIEAAVLYAEKH-GANSVGVNCCSLAAANAAVPRM 229 Query: 243 HGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCR 297 P+ V PN G+ H E+ A +W+ AGA ++G CC Sbjct: 230 VASATTPVTVRPNVGDPVQTQDGPVWH--ENPEAFARACIEWRHAGAAMVGSCCG 282 >UniRef50_D1CH13 Homocysteine S-methyltransferase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CH13_THET1 Length = 319 Score = 195 bits (497), Expect = 1e-48, Method: Composition-based stats. Identities = 66/332 (19%), Positives = 117/332 (35%), Gaps = 46/332 (13%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATELEARGC------------NLADSLWSAKVLVENP 48 M++N ++ Q +L DG ELE RG ++ +V +E+P Sbjct: 1 MARNP--LEIIRHQGYILGDGGYLIELERRGYVQSGSDREKVGTGKGSGQYTPEVAIEHP 58 Query: 49 ELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLA 108 + +RE+H ++ AG+Q ++ AT + G Q++A+ +V +AR+ Sbjct: 59 DALRELHTEFLMAGSQVLQALTFFATREKLSRAGYG-PQTEAINIAAVRIAREVA----- 112 Query: 109 ENPQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACE 168 LVA SV A + + + E + ++ L AG D L E Sbjct: 113 ----GERALVAASV-------ARTQLFEREGPAAREHARDLIAEQIRILTSAGVDFLILE 161 Query: 169 TLPNFSEIEALAELLTAYPRARAWFSFTLRDSEH-LSDGTPLRDVVALLAGYPQVVALGI 227 T + E+ E + + R SDG + + +G Sbjct: 162 TFFHLQEMLIALECARD-CGLPVMATMSFRPKTTESSDGYTPAECARAMVD-AGADIVGA 219 Query: 228 NCIA-LENTTAALQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCA----------Q 276 NC + + +P+ P + D + + + + Sbjct: 220 NCEQEPSRMLPIVLQMRAAVDVPIAAQPAAFRTSD-DTPCFTRMPQFPDDLETIQVSRRE 278 Query: 277 LADYLPQWQAAGARLIGGCCRTTPADIAALKA 308 AD+ Q + G + IGGCC A I A+ Sbjct: 279 FADFATQAISQGVQYIGGCCGANAAYIRAMAK 310 >UniRef50_B1A1E6 Homocysteine methyltransferase (Fragment) n=1 Tax=Flammeovirga yaeyamensis RepID=B1A1E6_9SPHI Length = 242 Score = 195 bits (496), Expect = 2e-48, Method: Composition-based stats. Identities = 80/223 (35%), Positives = 127/223 (56%), Gaps = 5/223 (2%) Query: 46 ENPELIREVHLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREA 105 E+I+ HL+Y ++GA+ I++SYQA+ GF +G + L+ K+ E+A+ A+E Sbjct: 1 HQEEVIKNAHLNYLKSGAEIIISSSYQASIKGFMEKGFSHEVAIDLLKKTTEIAQSAKEE 60 Query: 106 YLAENPQAGTLLVAGSVGPYGAYLADGSEYRG-DYHCSVEAFQAFHRPRVEALLDAGADL 164 Y + +AGS+GPY AYLADGSEY+G D ++FH R+ + D+ Sbjct: 61 YRE--ISKREVFIAGSIGPYAAYLADGSEYKGYDEAVDENTLRSFHNERLRIIDATDIDV 118 Query: 165 LACETLPNFSEIEALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVA 224 LA ET+P+ E + L +L+ AWFSF+ ++ + L+DGT + D+V+LL V+A Sbjct: 119 LAVETIPSLEEAKVLNDLIEKCGHK-AWFSFSCKNEKQLNDGTDIIDIVSLLKHNNNVMA 177 Query: 225 LGINCIALENTTAALQH-LHGLTVLPLVVYPNSGEHYDAVSKT 266 LGINC + + L+ +V+YPN+G Y+ +KT Sbjct: 178 LGINCTHPKYILGLISEILNAGWKKKIVIYPNAGMVYNPDTKT 220 >UniRef50_A6S563 Putative uncharacterized protein n=2 Tax=Sclerotiniaceae RepID=A6S563_BOTFB Length = 369 Score = 195 bits (496), Expect = 2e-48, Method: Composition-based stats. Identities = 80/362 (22%), Positives = 139/362 (38%), Gaps = 72/362 (19%) Query: 15 DILLLDGAMATEL---EARGCNLADSLWSAKVLV-ENPE---LIREVHLDYYRAGAQCAI 67 I LLDG + T L + LWS+++L+ +P + + AGA + Sbjct: 6 KIHLLDGGLGTTLGDSHQVQFTEKEPLWSSQLLIPTHPHGPKTLLATQKSFVDAGADILL 65 Query: 68 TASYQATPAGFAARGL---------------DEAQSKALIGKSVELARKAREAYLAENPQ 112 TA+YQ + GF G D+ + ++ +V++A A N + Sbjct: 66 TATYQTSYEGFGGSGYAVHSHSSSNSGKADGDKEEVNGIMRSAVDIASDAFSTKKDSNGK 125 Query: 113 AGTLLVAGSVGPYGAYLADGSEYRGDY---HCSVEAFQAFHRPRVEALLDAG-----ADL 164 +A S+G YGA + G EY G Y H S E ++H R+ D Sbjct: 126 -----IALSLGAYGAIMTPGQEYTGKYDDDHKSSEQLSSWHHERISVFSRDPKCWERVDY 180 Query: 165 LACETLPNFSEIEALAELLTAYPR--------ARAWFSFTLRDSEH-LSDGTPLRDVVAL 215 +A ET+P EIE + + + W + + L G+ ++ ++ Sbjct: 181 VAFETIPLLEEIEGVRKSMGEVENSNGGTAGSKPFWITCVFPGEGNCLPGGSSVQQIMQA 240 Query: 216 LAGYPQ----VVALGINCIALENTTAALQHLHG----------LTVLP-LVVYPNS---G 257 + G +G+NC + + + ++ P LVVYP+ G Sbjct: 241 MLGNKGGSPVPFGIGLNCTKVGKVESLILEFEQEVKALIEKGDVSEWPSLVVYPDGTIKG 300 Query: 258 EHYDAVSKTWHHHGEH-------CAQLADYLPQWQAAGA---RLIGGCCRTTPADIAALK 307 E Y+ +K W + + + + + G ++GGCC+TTP +I L+ Sbjct: 301 EVYNTSTKVWEIREPPGKEDLQWDEAVLEIVRRARDRGLWEDIIVGGCCKTTPREIGKLR 360 Query: 308 AR 309 R Sbjct: 361 ER 362 >UniRef50_P74718 Slr1189 protein n=1 Tax=Synechocystis sp. PCC 6803 RepID=P74718_SYNY3 Length = 351 Score = 194 bits (494), Expect = 3e-48, Method: Composition-based stats. Identities = 71/310 (22%), Positives = 127/310 (40%), Gaps = 29/310 (9%) Query: 14 QDILLLDGAMATE-LEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQC------- 65 + I LLDG + TE + RG +L ++A L+ +P L RE +Y+ Sbjct: 47 EQIFLLDGGLETEMIFNRGFDL--PAFAAHTLLSDP-LGREALKNYFHGFLDLAKEKQFG 103 Query: 66 --AITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVG 123 +++A P G+ + + ++VE AR ++AY+ E LL+ G +G Sbjct: 104 FLIDAPTWRAQPFFAEELGVSLEEIRQANFRAVEFARALKQAYVNEI---QPLLINGLIG 160 Query: 124 PYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELL 183 P G Y G++ + EA Q +HR ++ L +AG DLL TL + +E + Sbjct: 161 PCG------DAYGGEHFSNAEAAQVYHRQQISWLAEAGVDLLGAFTLTSVNEAIGIVRAS 214 Query: 184 TAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYP--QVVALGINCIALENTTAALQH 241 + SFT+ L GT L + +A++ +NC ++ A ++ Sbjct: 215 QEFS-LPVSISFTVETDGRLPTGTALSEAIAIVDEATNQGAAYFMVNCAHPDHFRAVIRE 273 Query: 242 LHGLTVL-PLVVYPNSGEHYDAVSKTWHHHGEHCAQLAD--YLPQWQAAGARLIGGCCRT 298 L+ L P S + + + + +LA + + + A + G CC + Sbjct: 274 EAWLSRLGGFRCNP-SRRSHAQLDQANFLDIGNPVELAHSYWTLKQKVPSANVFGACCGS 332 Query: 299 TPADIAALKA 308 I + Sbjct: 333 DLRHIREIAK 342 >UniRef50_A0Z513 Putative uncharacterized protein n=1 Tax=marine gamma proteobacterium HTCC2080 RepID=A0Z513_9GAMM Length = 306 Score = 193 bits (491), Expect = 7e-48, Method: Composition-based stats. Identities = 75/301 (24%), Positives = 106/301 (35%), Gaps = 25/301 (8%) Query: 16 ILLLDGAMATELEARGCNLA-DSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 I LLDG M EL R LWS +V+++ PEL+ VH D+ AGA+ +Y T Sbjct: 5 ITLLDGGMGQELIRRSSAAKPHPLWSLQVMMDEPELVANVHRDFCLAGARVICLNTYSVT 64 Query: 75 PAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSE 134 G + L+ + +LAR +A V S+ P A Sbjct: 65 RHRL-QMGNELPDLPELLKHAGDLARAGIQASGLHGID-----VVASLPPLTA------S 112 Query: 135 YRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFS 194 Y S + ++ +E L D ETL + +E EA+ + Sbjct: 113 YLKQSPLSPTQMKDEYKELME-LQRHHVDGFLAETLSSVAEGEAVLRAAQEA-GTGVHLA 170 Query: 195 FTL--RDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVV 252 FT+ D L G L D + + + +NC E L + T + Sbjct: 171 FTVQDEDGTLLRSGELLEDALRACVPLKPLSVI-LNCSIPEAIDQGLPLVAQATEI-FGA 228 Query: 253 YPNSGE------HYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRTTPADIAAL 306 Y N V A D QW GA ++GGCC PA I AL Sbjct: 229 YANGFHSVTALKPGGTVDVLTAREDLTPAAYTDMSLQWLELGASILGGCCEVGPAHIEAL 288 Query: 307 K 307 Sbjct: 289 A 289 >UniRef50_Q5UEY6 Putative homocysteine S-methyltransferase family protein n=1 Tax=uncultured alpha proteobacterium EBAC2C11 RepID=Q5UEY6_9PROT Length = 309 Score = 193 bits (490), Expect = 9e-48, Method: Composition-based stats. Identities = 71/310 (22%), Positives = 120/310 (38%), Gaps = 21/310 (6%) Query: 9 ALLDKQD---ILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQC 65 L+ K++ ++LD ++TELE RG + + WS V +++ E + E H+ Y AGA Sbjct: 7 ELIKKREQLLPIILDSGVSTELERRGAKMRNGQWSGCVAIDDYEKLVETHIAYIEAGADI 66 Query: 66 AITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPY 125 SY ++ GL + + + + ++ A +ARE + VAGS+ + Sbjct: 67 ITVNSYASSRLMLGPAGLGD-EVERINRLNISAAIEAREK------TGANVSVAGSIS-H 118 Query: 126 GAYLADGSEY-RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLT 184 DG E + S E + + + G DL+ E + + + L Sbjct: 119 ALPFTDGVEGAKQQPDISPEELSNCYGEMISIFENKGVDLILLEMMSIPARMAPLFNCAN 178 Query: 185 AYPRARAWFSFTLRDSEHLSDGTPLRDV------VALLAGYPQVVALGINCIALENTTAA 238 W + + L+ T D + + A A+GI +++ AA Sbjct: 179 K-SSLPIWCGLSAKRETPLAALTSWHDTSVSFEDIVIQACQYDFDAIGIMHTSVDAIEAA 237 Query: 239 LQHLHGLTVLPLVVYPNSGEHYDAVSKTWHHHGEHCAQLADYLPQWQAAGARLIGGCCRT 298 L + L+ YP+SG Y L +Y WQ +G + GGCC Sbjct: 238 LVVIKNHFSGMLMAYPDSG--YFVAPNWQFEDIIEPHALVEYAKGWQKSGCSIFGGCCGL 295 Query: 299 TPADIAALKA 308 P AL Sbjct: 296 GPEHTTALTE 305 >UniRef50_A8N5L5 Putative uncharacterized protein n=1 Tax=Coprinopsis cinerea okayama7#130 RepID=A8N5L5_COPC7 Length = 355 Score = 192 bits (488), Expect = 1e-47, Method: Composition-based stats. Identities = 85/358 (23%), Positives = 128/358 (35%), Gaps = 70/358 (19%) Query: 11 LDKQDILLLDGAMATELEARGCN--LADSLWSAKVLVENPELIREVHLDYYRAGAQCAIT 68 + K I +LDG + T LE + LWS + ++ +P + + H ++ AGA T Sbjct: 1 MPKPKIAILDGGLGTHLENIIGDEVSKGPLWSTQAVISHPLSVLKTHRNFINAGATIIET 60 Query: 69 ASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAY 128 A+YQA+ G GL E +++ L+ K+V LA++A A S+GP+GA Sbjct: 61 ATYQASLPGLIKSGLQEYEARELMWKAVSLAKEAAADSDASIA--------LSLGPFGAT 112 Query: 129 LADGSEYRGDYHCSV-------------------------EAFQAFHRPRVEALLDAGA- 162 L E+ G Y A FH R+ A Sbjct: 113 LRPTQEFEGFYPPPYGPKAYHPEGPNTQAFDSNEAEARAIGALAQFHLDRLLVFSQNSAV 172 Query: 163 ----DLLACETLPNFSEIEALAELLTAYP----------RARAWFSFTLRDSEHLSDGTP 208 LA ETL E+ A+ + + W SF + P Sbjct: 173 WDSIQYLAFETLLLPREVIAIRKAVGLLRTHLFKEHRSFDKSWWISFVVPSDATNPSVLP 232 Query: 209 LRDVVALLAGYPQVVALGINCIALENTTA-------ALQHLHGLTVLPLVVYPNSGEHYD 261 L L G+ A+GINC + + L+ L LV+YPN G YD Sbjct: 233 LVSSA-LCEGHDLPSAIGINCTSFGTLLPRTLELCRLVPRFRPLSQLGLVLYPNGG-TYD 290 Query: 262 AVSKTWHHHGEHCAQLADYLPQWQAAGA-----------RLIGGCCRTTPADIAALKA 308 ++ W + + G + GGCCRT P+ I+ Sbjct: 291 TTNQRWLPDPVDADRQWGLALRDVLTGVLSETGAEGWRELIAGGCCRTGPSHISQFAE 348 >UniRef50_Q4FMM0 Homocysteine S-methyltransferase n=2 Tax=Candidatus Pelagibacter ubique RepID=Q4FMM0_PELUB Length = 302 Score = 192 bits (488), Expect = 1e-47, Method: Composition-based stats. Identities = 69/307 (22%), Positives = 135/307 (43%), Gaps = 37/307 (12%) Query: 18 LLDGAMATELEARGCNLADSLWSAKVLV--ENPELIREVHLDYYRAGAQCAITASYQATP 75 +LDG M EL ARG +LWSA ++ E +L+ + HLD+ +AGA+ +TA++ Sbjct: 11 ILDGGMGQELLARGMKPNGTLWSANAVLKEEYHQLLLDTHLDFIKAGAEVIVTATFTTRR 70 Query: 76 AGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGSVGPYGAYLADGSEY 135 + E + + L K+ E+A+KA+E + +L+AG + P YL + Sbjct: 71 IRLRDNKI-EDKFEYLNKKAGEIAQKAKEQH-------PNVLIAGGLPP--QYLTYEEDT 120 Query: 136 RGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSF 195 R D + + + + LLD D + L + E + E + + Sbjct: 121 RPD-----DEIKQNFYDQAK-LLDPYIDFFYLDVLSSVKEFKLAIEAIEEF-NKPYLIGA 173 Query: 196 TLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYPN 255 + + +L G + D++ + + ++ L ++C++ EN L+ + L +P N Sbjct: 174 HISEGINLPSGEKISDIINNI-KHNNLLGLILSCVSPENFYENLEEVKNL-GVPFGFKLN 231 Query: 256 SGE---HYDAVSKTW-------------HHHGEHCAQLADYLPQWQAAGARLIGGCCRTT 299 + D + ++ +A+++ +++ AGA ++GGCC T Sbjct: 232 AFVTTNPKDGYTNSYNVSKTGNPNEFLGQRKDLTPELMANFVKKFKNAGATILGGCCETR 291 Query: 300 PADIAAL 306 P+ I + Sbjct: 292 PSHIKEM 298 >UniRef50_Q2G5H0 Homocysteine S-methyltransferase n=6 Tax=Bacteria RepID=Q2G5H0_NOVAD Length = 330 Score = 189 bits (481), Expect = 8e-47, Method: Composition-based stats. Identities = 62/317 (19%), Positives = 117/317 (36%), Gaps = 26/317 (8%) Query: 6 PLRALLDKQDILLLDGAMATE-LEARGCNLADSLWSAKVLVENPE---LIREVHLDYYRA 61 L L + + L D + T+ + RG +L +++ L+++ + + E + Sbjct: 23 ALAKLPQLESVFLTDAGLETDFIFNRGIDL--PYFASITLLQSSDGKIALEEYFRGFLEL 80 Query: 62 -----GAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTL 116 +A+++A+P GL + + L ++ + R R+ + + P + Sbjct: 81 ARRMRCGLILESATWRASPDWAEPLGLSQQELDTLNTSAIAILRDLRDEFGSTMPA---V 137 Query: 117 LVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEI 176 +++G +GP G Y S E +A+HR + E L AG D L T+ N E Sbjct: 138 VISGCLGPRG------DGYDPGKIMSEEGAEAYHRHQAEVLASAGVDQLTAITMTNVPEA 191 Query: 177 EALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQ--VVALGINCIALEN 234 +A+ + SFT+ L G L D + + INC + Sbjct: 192 IGIAKAAKSLA-VPVAISFTVETDGRLPTGDRLSDALRAVDQATASTPAYYMINCAHPSH 250 Query: 235 TTAALQHLHGLTVLPLVVYPNSGE-HYDAVSKTWHHHGEHCAQLADYLPQWQA--AGARL 291 A L+ + N+ + V + +LA + + + Sbjct: 251 FAAVLEDGADWVNRIGGLRANASRCSHAEVDAMSELDRGNPEELAALHSELRLRFPHINV 310 Query: 292 IGGCCRTTPADIAALKA 308 +GGCC T I A+ Sbjct: 311 LGGCCGTDLDHITAIAE 327 >UniRef50_A2R696 Contig An15c0240, complete genome n=9 Tax=Leotiomyceta RepID=A2R696_ASPNC Length = 353 Score = 189 bits (481), Expect = 1e-46, Method: Composition-based stats. Identities = 85/357 (23%), Positives = 141/357 (39%), Gaps = 66/357 (18%) Query: 11 LDKQDILLLDGAMATELEARG----CNLADSLWSAKVLVENPELIREVHLDYYRAGA-QC 65 + K IL+LDG + T L+ + LWS+ +++ +P + D+ A Sbjct: 1 MAKTPILILDGGLGTSLQDHYNITFSSSTTPLWSSHLMISDPSTLLSCQRDFTTTAAVDV 60 Query: 66 AITASYQATPAGFAAR-------GLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLV 118 +TA+YQ +P GF G+ + ++++A +A + A V Sbjct: 61 LLTATYQVSPEGFQRTKTPSHPTGIPRESIAGYLRTALDVAGQAVQNTSAS--------V 112 Query: 119 AGSVGPYGAYLADGSEYRGDY---HCSVEAFQAFHRPRVEALLD---------AGADLLA 166 A S+GPYGA + G EY G Y H + E +H R+ D +A Sbjct: 113 ALSLGPYGACMIPGQEYSGKYDGEHDTEEKLWRWHTDRLGLFNDEAMEGMRLGERVKYIA 172 Query: 167 CETLPNFSEIEALAELL---TAYPRARAWFS--FTLRDSEHLSDGTPLRDVVAL----LA 217 ET+P E+ A+ + W + F + D + L DG+ + +VV + Sbjct: 173 METVPRIDEVRAVRRAVGSSRFCEGIPFWVACVFPIEDKDTLPDGSTVDEVVEAALLPIE 232 Query: 218 GYPQVVALGINCIALENTTAALQHLHGLTVL-----------PLVVYPNS--GEHYDAVS 264 G +GINC L ++ LV+YP+ GE Y+ + Sbjct: 233 GGATPWGIGINCTKLHKLPRLVKLFGDAVERLLRDGRIQERPALVLYPDGTQGEVYNTAT 292 Query: 265 KTWHHHGEHCA---------QLADYLPQWQAAG---ARLIGGCCRTTPADIAALKAR 309 +TW + QLA + A G + L+GGCC+ + DI L+ + Sbjct: 293 QTWEKVQDKSGAADSRPWEVQLAQVVNDASATGQFSSILVGGCCKASFNDIKRLREQ 349 >UniRef50_B7G9Z1 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B7G9Z1_PHATR Length = 418 Score = 188 bits (478), Expect = 2e-46, Method: Composition-based stats. Identities = 110/372 (29%), Positives = 158/372 (42%), Gaps = 79/372 (21%) Query: 15 DILLLDGAMATELE-ARGCNLADSLWSAKVLVEN-------------------PELIREV 54 IL+LDG ++T LE ADS S K+ L+R+ Sbjct: 32 RILVLDGGVSTHLESNLSSTNADSASSDKLSCRTCAFPHRELWSSSLLLSESGRRLVRQG 91 Query: 55 HLDYYRAGAQCAITASYQATPA-------GFAARG-----LDEAQSKALIGKSVELARKA 102 H D+ RAGA T +YQ A +D+A L VE+A++A Sbjct: 92 HDDWLRAGANVLSTVTYQCHYQAAYWPKGKMATNDKDSRVMDDAVVNTLWNDGVEIAQQA 151 Query: 103 REAYLAENPQAG------------TLLVAGSVGPYGAYLADGSEYRGDYHC-SVEAFQAF 149 + Y + V S G YGA LA+G+EY G+Y +V+ F Sbjct: 152 VKDYCHNQQRPHTLRQPELETSSVPRYVVASSGCYGAILANGAEYTGNYGPVTVDDLVHF 211 Query: 150 HRPRVEALLDAGADLLACETLPNFSEIEALAELLTAYPRA--------RAWFSFTLRDSE 201 HR +V + D +A ET+P+ E AL +L A W S + R+ Sbjct: 212 HRRKVRRAVQLHPDGIAIETVPSLLECHALVQLFQPTNGAAPMLLNKTACWISLSCRNER 271 Query: 202 HLSDGTPLRDVVALLAGYP--QVVALGINCIALENTTAALQHLHGL--------TVLPLV 251 L+DGTPL + +L+ P V A G+NC ++ + A ++ L LV Sbjct: 272 ELNDGTPLVAALNVLSQIPCTAVSAWGLNCCSVTHLPALVRILTQHVAQEASGKHRRGLV 331 Query: 252 VYPNSGEHYDAVSKTWHHHGEH--CAQLADYL--------PQWQAA------GARLIGGC 295 +YPNSGE +DAV+ TWH A +A + +W+ + LIGGC Sbjct: 332 LYPNSGELWDAVTGTWHTGTGCTAPAAMASEIVAVLRTVEDEWRRHRPTDPTPSILIGGC 391 Query: 296 CRTTPADIAALK 307 CRT+PA IAAL+ Sbjct: 392 CRTSPATIAALR 403 >UniRef50_B0TW11 Betaine-homocysteine methyltransferase n=10 Tax=Bacteria RepID=B0TW11_FRAP2 Length = 356 Score = 188 bits (477), Expect = 3e-46, Method: Composition-based stats. Identities = 57/330 (17%), Positives = 114/330 (34%), Gaps = 38/330 (11%) Query: 2 SQNNPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRA 61 + L L+K ++ +G ELE RG LA + V++++PE++ +H ++ A Sbjct: 4 KKKEGLIERLNKGPVICAEG-FIFELERRGF-LASGEFVPTVVLDHPEIVEGLHREFQHA 61 Query: 62 GAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGS 121 G+ +Y A G E + L +++ +A+K ++ L+AG+ Sbjct: 62 GSDVVEALTYYAHREKLKVAG-QEHIIEDLNRQALRIAKKVADSAPK---GVQPNLMAGN 117 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 + + +GD +E + V ++ GAD++ ET E E Sbjct: 118 ICNSNIWK------QGDRKAQLE-VERMFDEMVTWAVEEGADMIIGETFSYAEEAFKAVE 170 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVALGINCI-ALENTTAALQ 240 ++ A + + DG + D L +G+NC + L+ Sbjct: 171 VIKK-SGLPAVLTIAPMGQNVMLDGWSIVDTCKELEQL-GADVVGLNCFRGPQTMLPYLK 228 Query: 241 HLHGLTVLPLVVYP-----------------NSGEHYDAVSKTWHHHGEHCA-----QLA 278 + + P N+G + ++ Sbjct: 229 DIRKAVKCHVAALPVPYRTTDDHPTFFNLPDNNGCSCPSPHGRPFPTALDPLFCNRYEIR 288 Query: 279 DYLPQWQAAGARLIGGCCRTTPADIAALKA 308 ++ + G +G CC +PA I + Sbjct: 289 EFAKEAYDFGVNYLGVCCGASPALIREVAE 318 >UniRef50_Q5KA93 Homocysteine S-methyltransferase, putative n=1 Tax=Filobasidiella neoformans RepID=Q5KA93_CRYNE Length = 381 Score = 187 bits (475), Expect = 4e-46, Method: Composition-based stats. Identities = 83/376 (22%), Positives = 140/376 (37%), Gaps = 85/376 (22%) Query: 15 DILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREVHLDYYRAGAQCAITASYQAT 74 +IL+LDG M T LE+ G +++ LW ++ L NP++IR+VH Y + GA TA+YQ T Sbjct: 4 NILVLDGGMGTTLESLGVDISSPLWGSEALRTNPDVIRKVHEGYVQGGADLVETATYQLT 63 Query: 75 PAGFAAR-GLDEAQSKALIGKSVELARKAR-------EAYLAENPQAGTLLVAGSVGPYG 126 P +++ ++ V+L E + ++ V S GPYG Sbjct: 64 PQNLCDHLHCPREEAECILCSGVKLVASCIASCSSRNEEHNTKSKGGNKSKVVLSFGPYG 123 Query: 127 AYLADGSEYRGDYHCSV---------------------EAFQAFHRPRVEALLDAG---- 161 + L G EY G Y +A H ++EA+ G Sbjct: 124 STLQPGQEYGGIYPPPFGPSTSTNAFPPDSNDEEEAAIQALAYHHLDKLEAISHDGAAWR 183 Query: 162 -ADLLACETLPNFSEIEALAELLTAYPR-----------------ARAWFSFTLRDSEH- 202 + +A ET+P E+ + + + W + +H Sbjct: 184 EVEWIAFETIPVLHEVRGIRRAMAILRGKLSALYADGDNIDLWWEKKFWITSPFPMGQHP 243 Query: 203 --LSDGT--PLRDVVALLAGYPQVV--ALGINCIALENTTAALQHLHGL------TVLPL 250 L DG+ + V+ L P + +GINC + + Sbjct: 244 QLLPDGSHASIPQVIHSLFSGPDPIPNGIGINCTNPSYLHFLSSSFTSHLPFEFFGKVEM 303 Query: 251 VVYPNSGEHYDAVSKTWH---HHGEHCAQLADYLPQWQAAGARLIGG------------- 294 V+YP+ G+ YD ++ W E+ + A+ + A G R G Sbjct: 304 VIYPDGGQMYDTTTRAWVVAPQSPENAEKWAEVVGD-VAKGVR--GAEREGKGVWKGVVV 360 Query: 295 --CCRTTPADIAALKA 308 CC+++ +I AL+ Sbjct: 361 GGCCKSSFDEIRALRR 376 >UniRef50_A6UMQ0 Homocysteine S-methyltransferase n=1 Tax=Sinorhizobium medicae WSM419 RepID=A6UMQ0_SINMW Length = 307 Score = 187 bits (475), Expect = 4e-46, Method: Composition-based stats. Identities = 62/314 (19%), Positives = 109/314 (34%), Gaps = 29/314 (9%) Query: 7 LRALLDKQDILLLDGAMATELEAR-GCNLADSLWSAKVLVENPELIREVHL---DYYRAG 62 L L D + DG M T+L G + L+++ VL+++PE + Y+ Sbjct: 4 LDRLFSSPDPFISDGGMETDLIFHEGAEM--PLFASFVLLDSPEGCEMLRRYAVSYFDLA 61 Query: 63 -----AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLL 117 T +++A GLD+A + + +++ AR R A+ P +L Sbjct: 62 QVASRGFVMGTPTWRANGGWGPKLGLDDAGIRDVNRRAIAFARDLRSAH----PWRDHIL 117 Query: 118 VAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIE 177 + G +GP G Y + + H ++E + D+ + T+ + E Sbjct: 118 IEGVLGPAG------DGYAPEQLLTPTEAARLHSAQLETFAEEDVDIASAFTITHPGEAI 171 Query: 178 ALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQ--VVALGINCIALENT 235 + SFT+ L G L + + V GINC E+ Sbjct: 172 GMVNRARDL-GLPFALSFTVETDGRLPTGQDLDCALDEVEAATGGYVRYYGINCAHPEHF 230 Query: 236 TAALQHLHGLTVLPLVVYPNSG-EHYDAVSKTWHHHGEHCAQLADYLPQWQAAG--ARLI 292 L VV PN+ + + + + + R++ Sbjct: 231 GEQLP--SRWLNRIGVVRPNASRRSHAELDEATELDDGDPQEFGALYAEMAEKLPRLRVV 288 Query: 293 GGCCRTTPADIAAL 306 GGCC + I AL Sbjct: 289 GGCCGSDMRHIKAL 302 >UniRef50_A3JU33 Homocysteine S-methyltransferase n=3 Tax=Rhodobacterales RepID=A3JU33_9RHOB Length = 314 Score = 184 bits (468), Expect = 3e-45, Method: Composition-based stats. Identities = 65/321 (20%), Positives = 124/321 (38%), Gaps = 30/321 (9%) Query: 1 MSQNNPLRALLDKQDILLLDGAMATEL-EARGCNLADSLWSAKVLVENPELIREVHLDYY 59 M+Q++P + ++I L DG T L RG L +SA L+ N + + +YY Sbjct: 1 MTQSSP-QLPHQTKEIFLTDGGTETWLMYKRGFEL--PEFSAFHLLNNQQSTAAL-KEYY 56 Query: 60 RAGAQCAI---------TASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAEN 110 A A A+ + +Y+A+ A G + K +L R+ + Sbjct: 57 TAFADVAMQLGTPFIFDSLTYRASRDWGALLGYSSEGLADMNHKCFDLYRECA---TKAS 113 Query: 111 PQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETL 170 A +++G +GP G Y+ + + ++ +A+H ++E +AG D++ TL Sbjct: 114 LTAQNTIISGCIGPKG------DAYQTNKTLNAQSAEAYHAEQIETFKNAGVDIITALTL 167 Query: 171 PNFSEIEALAELLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYP--QVVALGIN 228 E +A +A + +FT+ + L G L+ + + IN Sbjct: 168 NTTDEAIGIARA-SAKAGIPSVIAFTIEKNRKLRSGETLKQAIEAVDAATADAPAYYMIN 226 Query: 229 CIALENTTAALQHLHGLTVLPLVVYPNS-GEHYDAVSKTWHHHGEHCAQLADYLPQWQAA 287 C + AL + + N+ + + + H +LA +++ Sbjct: 227 CSHPVDFGPALTSEPWANRIR-GLRANASSLDHGTLCQLGHLEEGDPDELAQQYVDIRSS 285 Query: 288 G--ARLIGGCCRTTPADIAAL 306 + GGCC T A + + Sbjct: 286 HPKMNVFGGCCGTDYAHVEKI 306 >UniRef50_C3M8I7 Homocysteine S-methyltransferase n=4 Tax=Bacteria RepID=C3M8I7_RHISN Length = 322 Score = 183 bits (464), Expect = 9e-45, Method: Composition-based stats. Identities = 60/312 (19%), Positives = 109/312 (34%), Gaps = 27/312 (8%) Query: 11 LDKQDILLLDGAMATEL-EARGCNLADSLWSAKVLVENPELIREV---HLDYYRAG---- 62 L + L DG M T L G L +++ VL+ + E R++ + Y Sbjct: 14 LLQGGTFLSDGGMETALIFQEGVEL--PHFASFVLLSSMEGRRQLLHYYTSYLEIARCRD 71 Query: 63 -AQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGS 121 TA+++A G D + +V L + R Y ++ G Sbjct: 72 TGFVLDTATWRANADWGEKLGYDAEDLDQVNRDAVYLLTELRAQYERPQV---PIVFNGV 128 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 +GP G G + + +H +V A D+ AD+++ T+ N E +A Sbjct: 129 IGPRGDGYKAGM-------MNAAEAEDYHAAQVAAFADSEADMVSAVTMTNVDEAIGVAR 181 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQVVA--LGINCIALENTTAAL 239 + SFT+ L G L++ V + + +NC + ++L Sbjct: 182 AARTH-GMPCAISFTVETDGRLVTGRSLQEAVETVDAETEAYPHYYMVNCAHPSHFESSL 240 Query: 240 QHLHGLTVLPLVVYPNSG-EHYDAVSKTWHHHGEHCAQLADYLPQW--QAAGARLIGGCC 296 + N+ + + + ++ LA + R++GGCC Sbjct: 241 DQDQAWVRRIGGIRANASTKSHAELDESETLDIGDINDLARRYRSLTGRLPHLRVLGGCC 300 Query: 297 RTTPADIAALKA 308 T IAA+ Sbjct: 301 GTDHRHIAAICE 312 >UniRef50_A6U723 Homocysteine S-methyltransferase n=11 Tax=Bacteria RepID=A6U723_SINMW Length = 322 Score = 182 bits (462), Expect = 1e-44, Method: Composition-based stats. Identities = 61/312 (19%), Positives = 106/312 (33%), Gaps = 27/312 (8%) Query: 11 LDKQDILLLDGAMATELEAR-GCNLADSLWSAKVLVENPELIREVHLDY--------YRA 61 L + + L DG M T L G +L +++ VL+ + E R++ Y A Sbjct: 14 LVRGGMFLSDGGMETALIFHEGVDL--PHFASFVLLSSAEGRRQLLRYYTRYLEIARRHA 71 Query: 62 GAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKAREAYLAENPQAGTLLVAGS 121 TA+++A G D K + +V L R Y +++ G Sbjct: 72 TGFVLDTATWRANADWGEKLGFDAEALKKVNRDAVYLLTGLRSEYERPEA---PVVLNGV 128 Query: 122 VGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRVEALLDAGADLLACETLPNFSEIEALAE 181 +GP G YR + + +H ++ AL + AD++ T+ N E + Sbjct: 129 IGPRG------DGYRAGR-MTAIEAEDYHSAQIAALSGSEADMITAVTMTNTEEAIGIVR 181 Query: 182 LLTAYPRARAWFSFTLRDSEHLSDGTPLRDVVALLAGYPQ--VVALGINCIALENTTAAL 239 SFT+ L G PL + + + INC + L Sbjct: 182 SAR-NHDMPCAISFTVETDGRLITGRPLEHAIETVDAETDGYPLYYMINCAHPSHFENML 240 Query: 240 QHLHGLTVLPLVVYPNSG-EHYDAVSKTWHHHGEHCAQLADYLPQWQAA--GARLIGGCC 296 + N+ + + + ++ LA+ R++GGCC Sbjct: 241 DRQSAWVRRIGGIRANASTKSHAELDESETLDAGDVCDLAERYRSLTRHLPHLRVLGGCC 300 Query: 297 RTTPADIAALKA 308 T I A+ Sbjct: 301 GTDHRHITAICE 312 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.311 0.149 0.444 Lambda K H 0.267 0.0460 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 1,910,415,126 Number of Sequences: 3077464 Number of extensions: 75852075 Number of successful extensions: 270021 Number of sequences better than 1.0e-01: 250 Number of HSP's better than 0.1 without gapping: 705 Number of HSP's successfully gapped in prelim test: 235 Number of HSP's that attempted gapping in prelim test: 264966 Number of HSP's gapped (non-prelim): 1120 length of query: 310 length of database: 1,040,396,356 effective HSP length: 128 effective length of query: 182 effective length of database: 646,480,964 effective search space: 117659535448 effective search space used: 117659535448 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 93 (40.3 bits)