Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	A	A	A	K	T	Q	K	P	K	R	Q	E	E	H	A	N	F	I	S	W	R	F	A	L	L	C	G	C	I	L	L	A	L	A	F	L	L	G	R	V	A	W	L	Q	V	I	S	P	D	M	L	V	K	E	G	D	M	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																																									?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	L	R	V	Q	Q	V	S	T	S	R	G	M	I	T	D	R	S	G	R	P	L	A	V	S	V	P	V	K	A	I	W	A	D	P	K	E	V	H	D	A	G	G	I	S	V	G	D	R	W	K	A	L	A	N	A	L	N	I	P
Secondary structure
SS confidence
Disorder		?	?					?	?																																?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	D	Q	L	S	A	R	I	N	A	N	P	K	G	R	F	I	Y	L	A	R	Q	V	N	P	D	M	A	D	Y	I	K	K	L	K	L	P	G	I	H	L	R	E	E	S	R	R	Y	Y	P	S	G	E	V	T	A	H	L	I	G
Secondary structure
SS confidence
Disorder											?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		F	T	N	V	D	S	Q	G	I	E	G	V	E	K	S	F	D	K	W	L	T	G	Q	P	G	E	R	I	V	R	K	D	R	Y	G	R	V	I	E	D	I	S	S	T	D	S	Q	A	A	H	N	L	A	L	S	I	D	E	R	L
Secondary structure
SS confidence
Disorder								?																												?		?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Q	A	L	V	Y	R	E	L	N	N	A	V	A	F	N	K	A	E	S	G	S	A	V	L	V	D	V	N	T	G	E	V	L	A	M	A	N	S	P	S	Y	N	P	N	N	L	S	G	T	P	K	E	A	M	R	N	R	T	I	T
Secondary structure
SS confidence
Disorder																	?																														?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		D	V	F	E	P	G	S	T	V	K	P	M	V	V	M	T	A	L	Q	R	G	V	V	R	E	N	S	V	L	N	T	I	P	Y	R	I	N	G	H	E	I	K	D	V	A	R	Y	S	E	L	T	L	T	G	V	L	Q	K	S	S
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		N	V	G	V	S	K	L	A	L	A	M	P	S	S	A	L	V	D	T	Y	S	R	F	G	L	G	K	A	T	N	L	G	L	V	G	E	R	S	G	L	Y	P	Q	K	Q	R	W	S	D	I	E	R	A	T	F	S	F	G	Y	G
Secondary structure
SS confidence
Disorder																													?	?			?						?									?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		L	M	V	T	P	L	Q	L	A	R	V	Y	A	T	I	G	S	Y	G	I	Y	R	P	L	S	I	T	K	V	D	P	P	V	P	G	E	R	V	F	P	E	S	I	V	R	T	V	V	H	M	M	E	S	V	A	L	P	G	G	G
Secondary structure
SS confidence
Disorder																															?	?	?	?	?	?	?																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		G	V	K	A	A	I	K	G	Y	R	I	A	I	K	T	G	T	A	K	K	V	G	P	D	G	R	Y	I	N	K	Y	I	A	Y	T	A	G	V	A	P	A	S	Q	P	R	F	A	L	V	V	V	I	N	D	P	Q	A	G	K	Y
Secondary structure
SS confidence
Disorder																							?	?	?	?	?	?	?																														?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.
Sequence		Y	G	G	A	V	S	A	P	V	F	G	A	I	M	G	G	V	L	R	T	M	N	I	E	P	D	A	L	T	T	G	D	K	N	E	F	V	I	N	Q	G	E	G	T	G	G	R	S
Secondary structure
SS confidence
Disorder		?																									?	?	?	?	?	?	?	?	?		?		?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3oc2 chain A Region: 59 - 568 Aligned: 491 Modelled: 510 Confidence: 100.0% Identity: 48% PDB header:penicillin-binding protein Chain: A: PDB Molecule:penicillin-binding protein 3; PDBTitle: crystal structure of penicillin-binding protein 3 from pseudomonas2 aeruginosa Phyre2 PDB 3pbq chain A Region: 62 - 570 Aligned: 490 Modelled: 509 Confidence: 100.0% Identity: 47% PDB header:hydrolase/antibiotic Chain: A: PDB Molecule:penicillin-binding protein 3; PDBTitle: crystal structure of pbp3 complexed with imipenem Phyre2 PDB 1pmd chain A Region: 71 - 576 Aligned: 500 Modelled: 500 Confidence: 100.0% Identity: 23% PDB header:peptidoglycan synthesis Chain: A: PDB Molecule:peptidoglycan synthesis multifunctional enzyme; PDBTitle: penicillin-binding protein 2x (pbp-2x) Phyre2 PDB 3ue3 chain A Region: 64 - 568 Aligned: 429 Modelled: 438 Confidence: 100.0% Identity: 45% PDB header:transferase Chain: A: PDB Molecule:septum formation, penicillin binding protein 3, PDBTitle: crystal structure of acinetobacter baumanni pbp3 Phyre2 PDB 1mwu chain A Region: 55 - 566 Aligned: 479 Modelled: 505 Confidence: 100.0% Identity: 22% PDB header:biosynthetic protein Chain: A: PDB Molecule:penicillin-binding protein 2a; PDBTitle: structure of methicillin acyl-penicillin binding protein 2a2 from methicillin resistant staphylococcus aureus strain3 27r at 2.60 a resolution. Phyre2 PDB 3equ chain B Region: 62 - 570 Aligned: 424 Modelled: 433 Confidence: 100.0% Identity: 41% PDB header:biosynthetic protein Chain: B: PDB Molecule:penicillin-binding protein 2; PDBTitle: crystal structure of penicillin-binding protein 2 from neisseria2 gonorrhoeae Phyre2 PDB 1qmf chain A Region: 66 - 574 Aligned: 410 Modelled: 416 Confidence: 100.0% Identity: 28% PDB header:peptidoglycan synthesis Chain: A: PDB Molecule:penicillin-binding protein 2x; PDBTitle: penicillin-binding protein 2x (pbp-2x) acyl-enzyme complex Phyre2 PDB 2wad chain B Region: 64 - 564 Aligned: 475 Modelled: 487 Confidence: 100.0% Identity: 24% PDB header:peptide binding protein Chain: B: PDB Molecule:penicillin-binding protein 2b; PDBTitle: penicillin-binding protein 2b (pbp-2b) from streptococcus2 pneumoniae (strain 5204) Phyre2 PDB 3lo7 chain A Region: 164 - 559 Aligned: 361 Modelled: 375 Confidence: 100.0% Identity: 28% PDB header:transferase Chain: A: PDB Molecule:penicillin-binding protein a; PDBTitle: crystal structure of pbpa from mycobacterium tuberculosis Phyre2 PDB 1pyy chain A domain 4 Region: 235 - 569 Aligned: 332 Modelled: 332 Confidence: 100.0% Identity: 25% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 1rp5 chain A domain 4 Region: 235 - 572 Aligned: 334 Modelled: 338 Confidence: 100.0% Identity: 25% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 1vqq chain A domain 3 Region: 236 - 564 Aligned: 312 Modelled: 329 Confidence: 100.0% Identity: 19% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 2c5w chain B domain 1 Region: 222 - 571 Aligned: 324 Modelled: 335 Confidence: 100.0% Identity: 21% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 1k25 chain A domain 4 Region: 235 - 569 Aligned: 305 Modelled: 311 Confidence: 100.0% Identity: 27% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 3udi chain A Region: 227 - 569 Aligned: 294 Modelled: 326 Confidence: 100.0% Identity: 24% PDB header:penicillin-binding protein/antibiotic Chain: A: PDB Molecule:penicillin-binding protein 1a; PDBTitle: crystal structure of acinetobacter baumannii pbp1a in complex with2 penicillin g Phyre2 PDB 3dwk chain C Region: 226 - 588 Aligned: 327 Modelled: 343 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: C: PDB Molecule:penicillin-binding protein 2; PDBTitle: identification of dynamic structural motifs involved in2 peptidoglycan glycosyltransfer Phyre2 PDB 3fwl chain A Region: 222 - 583 Aligned: 316 Modelled: 343 Confidence: 100.0% Identity: 22% PDB header:transferase, hydrolase Chain: A: PDB Molecule:penicillin-binding protein 1b; PDBTitle: crystal structure of the full-length transglycosylase pbp1b2 from escherichia coli Phyre2 PDB 2bg1 chain A Region: 227 - 583 Aligned: 314 Modelled: 328 Confidence: 100.0% Identity: 17% PDB header:peptidoglycan Chain: A: PDB Molecule:penicillin-binding protein 1b; PDBTitle: active site restructuring regulates ligand recognition in2 classa penicillin-binding proteins (pbps) Phyre2 PDB 2olv chain A Region: 226 - 588 Aligned: 331 Modelled: 349 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:penicillin-binding protein 2; PDBTitle: structural insight into the transglycosylation step of bacterial cell2 wall biosynthesis : donor ligand complex Phyre2 PDB 2jci chain A Region: 228 - 584 Aligned: 314 Modelled: 328 Confidence: 100.0% Identity: 17% PDB header:drug-binding protein Chain: A: PDB Molecule:penicillin-binding protein 1b; PDBTitle: structural insights into the catalytic mechanism and the2 role of streptococcus pneumoniae pbp1b Phyre2 1 c3oc2A_ 2 c3pbqA_ 3 c1pmdA_ 4 c3ue3A_ 5 c1mwuA_ 6 c3equB_ 7 c1qmfA_ 8 c2wadB_ 9 c3lo7A_ 10 d1pyya4 11 d1rp5a4 12 d1vqqa3 13 d2c5wb1 14 d1k25a4 15 c3udiA_ 16 c3dwkC_ 17 c3fwlA_ 18 c2bg1A_ 19 c2olvA_ 20 c2jciA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111